bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation in in-hospital mortality and its association with percutaneous coronary intervention-related bleeding complications: A report from nationwide registry in Japan
Authors: Sawayama Yuichi , Yamaji Kyohei , Kohsaka Shun , Yamamoto Takashi , Higo Yosuke , Numasawa Yohei , Inohara Taku , Ishii Hideki , Amano Tetsuya , Ikari Yuji , Nakagawa Yoshihisa
Published: December 2021

Large-scale registries have demonstrated that in-hospital mortality after percutaneous coronary intervention (PCI) varies widely across institutions. However, whether this variation is related to major procedural complications (e.g., bleeding) is unclear. In this study, institutional variation in in-hospital mortality and its association with PCI-related bleeding complications were investigated. We analyzed 388,866 procedures at 718 hospitals performed from 2017 to 2018, using data from a nationwide PCI registry in Japan. Hospitals were stratified into quintiles according to risk-adjusted in-hospital mortality (very low, low, medium, high, and very high). Incidence of bleeding complications, defined as procedure-related bleeding events that required a blood transfusion, and in-hospital mortality in patients who developed bleeding complications were calculated for each quintile. Overall, 4,048 (1.04%) in-hospital deaths and 1,535 (0.39%) bleeding complications occurred. Among patients with bleeding complications, 270 (17.6%) died during hospitalization. In-hospital mortality ranged from 0.22% to 2.46% in very low to very high mortality hospitals. The rate of bleeding complications varied modestly from 0.27% to 0.57% (odds ratio, 1.95; 95% confidence interval, 1.58–2.39). However, mortality after bleeding complications markedly increased by quintile and was 6-fold higher in very high mortality hospitals than very low mortality hospitals (29.0% vs. 4.8%; odds ratio, 12.2; 95% confidence interval, 6.90–21.7). In conclusion, institutional variation in in-hospital mortality after PCI was associated with procedure-related bleeding complications, and this variation was largely driven by differences in mortality after bleeding complications rather than difference in their incidence. These findings underscore the importance of efforts toward reducing not only bleeding complications but also, even more importantly, subsequent mortality once they have occurred.
An exploration of the use of 3D printed foot models and simulated foot lesions to supplement scalpel skill training in undergraduate podiatry students: A multiple method study
Authors: Banwell Helen A. , Causby Ryan S. , Crozier Alyson J. , Nettle Brendan , Murray Carolyn
Published: December 2021

Background

Podiatrists regularly use scalpels in the management of foot pathologies, yet the teaching and learning of these skills can be challenging. The use of 3D printed foot models presents an opportunity for podiatry students to practice their scalpel skills in a relatively safe, controlled risk setting, potentially increasing confidence and reducing associated anxiety. This study evaluated the use of 3D printed foot models on podiatry students’ anxiety and confidence levels and explored the fidelity of using 3D foot models as a teaching methodology.

Materials and methods

Multiple study designs were used. A repeated measure trial evaluated the effects of a 3D printed foot model on anxiety and confidence in two student groups: novice users in their second year of podiatry studies (n = 24), and more experienced fourth year students completing a workshop on ulcer management (n = 15). A randomised controlled trial compared the use of the 3D printed foot models (n = 12) to standard teaching methods (n = 15) on students’ anxiety and confidence in second year students. Finally, a focus group was conducted (n = 5) to explore final year student’s perceptions of the fidelity of the foot ulcer models in their studies.

Results

The use of 3D printed foot models increased both novice and more experienced users’ self-confidence and task self-efficacy; however, cognitive and somatic anxiety was only reduced in the experienced users. All changes were considered large effects. In comparison to standard teaching methods, the use of 3D printed foot models had similar decreases in anxiety and increases in confidence measures. Students also identified the use of 3D foot models for the learning of scalpel skills as ‘authentic’ and ‘lifelike’ and led to enhanced confidence prior to assessment of skills in more high-risk situations.

Conclusion

Podiatry undergraduate programs should consider using 3D printed foot models as a teaching method to improve students’ confidence and reduce their anxiety when using scalpels, especially in instances where face-to-face teaching is not possible (e.g., pandemic related restrictions on face-to-face teaching).
Clothing and the oceanic identity in Melville’s Redburn
Authors: Traber Daniel S.
Published: December 2021

Herman Melville’s Redburn approaches the topic of corporeal coding via the outer layer of clothing. Throughout the novel, the young protagonist consciously uses clothing as a means of self-representation and expression, deploying fashion to create and position himself in different contexts; for example, taking pride in his ragged clothes amongst well-dressed ship passengers becomes a form of social protest. But Redburn is also used to comic effect because his choices are often based on incorrect assumptions of propriety, such as his notion of the way a sailor is supposed to dress not matching the onboard reality. The rules of appearance that construct and restrain an identity are paradoxically bolstered at the same time they are broken, which allows Melville the opportunity to explore rebellion alongside the performative aspect of the self as a body constituting both a visible sign and a living vehicle for the mores, beliefs and ideologies that shape a society.
Reinstitute: Performing methods of undress, má and decolonial aestheSis
Authors: Mabitsela Lesiba
Published: December 2021

This article focuses on an analysis of Reinstitute, which was a performance intervention that was implemented in 2019, and which had the aim of troubling the construction and embodiment of the suit, which is proposed here as a garment that idolizes an inherently violent, hegemonic, Euro-American notion of masculinity. This idea of masculinity finds itself replicated on the African continent, including in the structure and curatorial practices of many of the continent’s cultural institutions, due to the legacy of colonialism. By incorporating alternative design and philosophical ideologies such as sartorial resistance, states of undress and the Japanese concept of má in the creation of sartorial alternatives to the suit, Reinstitute offers new insights into the practice of decolonial aestheSis.
‘All Tee, No Shade’: A manifesto for a subtle critical practice negotiating queer, East Asian masculinities through T-shirts
Authors: Thai Sang
Published: December 2021

‘All Tee, No Shade’ is a practice-led research project that explores the use of the men’s T-shirt to challenge and disrupt hegemonic subjectivities that contribute to the marginalization and discrimination of the queer Asian diaspora. Through an exploration of my pilot project of the same name, produced as part of the arts programme of Virgin Australian Melbourne Fashion Festival in 2020, I propose that norm-critical design methodologies exploring intersectional experiences of fashion and dress can produce material outcomes that challenge the discrimination and oppression associated with compounding conditions of race and sexuality. I use the notion of ‘subtle’ traits as a condition of the East Asian diasporic experience to reveal how race and sexuality might be expressed through fashion production to disrupt conceptions of ‘otherness’. This is achieved with T-shirts that have printed graphic configurations that align with contemporary streetwear but with ‘subtle’ signifiers embedded through the signs and lexicons of Asian and queer communities. Using an autoethnographic approach, the work is informed by my past fashion design industry experience and reflects on racial and queer marginalization and discrimination through styling and fit. The project contributes to broader discourses aimed at decentralizing dominant narratives in fashion practice and responds to a lack of academic research into diasporic Asian experiences of dress and, more specifically, queer diasporic Asian dress.
Queer insurgency: Slava Mogutin and the politics of camp
Authors: Roberts Graham H.
Published: December 2021

The subject of this article is Russo-American artist Slava Mogutin. A close associate of Gosha Rubchinskiy and Lotta Volkova, Mogutin has been based in New York since 1995. While he originally shot to fame as a poet and novelist, Mogutin is today better known as a performance artist, filmmaker and photographer. The aim of my article is to locate Mogutin, and in particular his fashion photography, within current debates around the representation of masculinity and the construction of masculine subjectivity/-ies. More specifically, using a visual analysis methodology, I analyse the camp aesthetics of Mogutin’s fashion imagery. In a number of ways, Mogutin’s camp aesthetic raises questions about displacement and identity, the clash between individual desires and social norms and – as he puts it – ‘what it means to be a young man in the modern world’. It also constitutes an avowedly political challenge, not just to the state-sponsored homophobia and heteronormativity of Mogutin’s native Russia but also to the identity politics underpinning today’s fashion industry. I conclude by suggesting that Mogutin’s openly political form of camp might pose a challenge to the traditional Sontagian view of camp as apolitical.
Green your groin: Sustainability, men’s underwear and the wild
Authors: Allan Jonathan A.
Published: December 2021

Men and the environment, it seems, have a tenuous relationship. This article considers the challenge of men’s underwear and sustainability by focusing on advertisements designed to sell ecologically friendly underwear. One of the challenges that I highlight is how we are to ‘read’ these advertisements. This article takes it as a given that images are polysemous. Drawing on queer theory, I propose a series of readings that align with Sedgwick’s practice of paranoid and reparative reading. In the case of the paranoid reading, I show how these advertisements might be read as indicative and proof of hybrid masculinity theory. From this vantage, I move to a reparative reading that imagines other possibilities, particularly around nature and the wild. The goal of these readings is not to have one dominate over the other, but to show the nuance and complexity of masculinities in/and nature.
‘Not all socialists dress the same’: Menswear as cultural capital in China
Authors: Bednall Anthony Lawrence
Published: December 2021

Chinese sartorial style, like many cultures, has been defined, formalized and articulated to its population by hierarchical definition and visual association. Menswear styles have transitioned from strict Imperial codes, to westernized adoption, designed to shape a new modernism, as various leadership regimes imposed and defined dress codes to implement political and cultural structures. Sustainable practices were developed through the design and construction methods of Imperial garments and as a response to low resources, famine and inefficient management systems during the early years of the People’s Republic of China. This period was characterized by rationing for fabrics, recycling and the re-invention of existing garments. Through a contemporary lens, this can be viewed as an integrated sustainable approach to the mass clothing of a significantly sized population. However, intervening regimes including the post-Imperial Nationalist leadership and the post-Mao Communist leadership cultivated a new visual identity for the Chinese population as westernization became the prefix for modernization. This article aims to map the historical development of menswear as cultural capital in China, to contextualize sustainable practices in the production of garments and define how these practices were systematically and repeatedly rejected in favour of new consumerism. It also aims to historically define the role of menswear in China as a representation of the nation’s outward-facing international image and ambitions as a serious and contemporary player, within the global political and cultural community.
No man is an island: The sustainability awareness effect of geography on hedonic fashion consumption and connection with nature – evidence from Galápagos and Hawaiʻi
Authors: Pohlmann Attila
Published: December 2021

The demand for ever-accelerating fast fashion is unprecedented, while its supply chain burdens environmental systems. Hedonic fashion consumption is generally unfettered by sustainability concerns, but evidence suggests that island geographies–with dense boundaries between the built and the natural environment–have a heightening effect on eco-consciousness. A framework based on the contemporary condition of hyperconsumption is proposed: island geography heightens sustainability awareness; consequently, fashion consumers located on islands trade-off perceived hedonic benefits of fashion consumption against perceived moral benefits of connection with nature. The framework is supported by visual evidence collected on the Galápagos island Santa Cruz, indicating that male fashion consumers express connection with nature by means of tattoos, slogans on clothing and choice of eco-friendly materials. Quantitative tests with survey data from the United States and Ecuador show that residents in Hawaiʻi and the Galápagos have higher levels of connection with nature compared to residents on the associated continental areas. This effect is mediated by decreased perceived rewards of hedonic fashion consumption, but the effect is overall weaker in Ecuador compared to the United States due to differences in purchasing power and attitudes towards consumerism. Because of the stereotype that eco-friendly is unmanly, men are generally less likely to embrace environmentally friendly products and the findings of this research point to avenues to overcome this barrier.
Stumbling into sustainability: The effectual marketing approach of Ecuadorian entrepreneurs to reframe masculinity and accelerate the adoption of slow fashion
Authors: Pohlmann Attila , Muñoz-Valencia Rodrigo
Published: December 2021

The prevalent business model of fast fashion has received widespread criticism for being antithetical to sustainability. Therefore, many Gen-Y fashion entrepreneurs routinely base their business models on principles of sustainability. Additionally, the green-feminine stereotype not only hinders male consumers’ adoption of ecofriendly products but also poses cultural obstacles for male slow fashion entrepreneurs. By example of the Ecuadorian slow fashion company Remu Apparel, this article investigates how male entrepreneurs craft alternative masculinities through both personal and marketing narratives with the intent to mobilize the adoption of slow fashion and to overcome the aforementioned stereotype by reframing hegemonic masculinity. Interviews with the company’s founders indicate that the causal fast fashion business model is recognized as harmful and unsustainable; consequently, a sustainability-oriented, effectual, slow fashion business approach is implemented, which opposes the globalized hegemonic business system and concurrently challenges and reframes traditional masculinity. Through respect for natural growth, intermittent compromises and career as self-discovery, an alternative, reflective masculinity is crafted and enshrined in Remu’s business objectives. A visual content analysis indicates that social media tools are used to promote and stabilize the image of this alternative masculinity. The findings highlight avenues to mobilize slow fashion adoption within entrepreneurial networks and how sustainable, ecofriendly fashion can be promoted among male consumers.
EVALUACIÓN DEL PERFIL DE VIRULENCIA DE Campylobacter TERMOTOLERANTES AISLADOS DE GRANJAS COMERCIALES DE POLLOS PARRILLEROS
Authors: Rossler E
Published: December 2021

The aim of this work was to analyze the presence of genes associated with the virulence of thermotolerant Campylobacter (CT) isolated from different sources in commercial broiler farms. For this, we worked with a collection of CT isolates obtained from three commercial broiler farms during 2015. The presence of 10 genes related to CT virulence was examined with a PCR reaction. The results showed a prevalence of 100% for flaA and flhA; 91% cadF, 51% cdtABC, 48% iam, 46% racR, 32% ciaB and 11% virB11. C. jejuni showed higher prevalence of all genes evaluated than C. coli, except iam and virB11 wich were higher for C. coli. The same gene pattern was presented in different sources of isolates. The high prevalence of flaA and flhA, involved in CT mobility, cadF related to Campylobacter gut colonization of broiler and cdtABC genes involved for the expression of cytotoxin, indicates the importance of these factors in CT virulence. Differences in the prevalence of genes according to the species of CT could demonstrate different mechanisms of pathogenicity, and this is not related to the source of isolates. All the results showed the ability of CT to colonize cells but is not evidence of pathogenesis.
CRECIMIENTO Y CARACTERÍSTICAS FERMENTATIVAS DE Kluyveromyces marxianus EN MATRICES DERIVADAS DE LACTOSUERO
Authors: Gómez G A
Published: December 2021

Milk whey has a high content of organic matter; therefore, uncontrolled discharge can cause environmental problems. An alternative for whey utilization is the production of fermented alcoholic beverages by means of the yeast Kluyveromyces marxianus, able to use lactose as a carbon source. Four different liquid growth media were prepared: whey powder (SP) and demineralized whey powder (SPD) (65 g/L) dissolved in sterilized distilled water; SPCal, similar to SP in composition, but sterilized and centrifuged to remove proteins, and milk permeate (PER). All media were fermented by 24 hours at 30°C. Samples were taken every 8 hours, for pH, biomass, ethanol and lactose determination. K. marxianus (LFIQK1 strain) growth was similar in SP, SPD and SP Cal (biomass between 2 – 3 g/L) and lower in PER. Moderate pH decline was observed, final values being between 4,7 and 5,4. Significant lactose consumption was observed in every growth media, with final values around 12 g/L and good ethanol production, especially for SP, SPD, and PER mediums (17,0±0,7; 17,6±0,5; 16,3±0,2 g/L respectively). These results are encouraging for the production of alcoholic beverages from the studied media using K. marxianus as the fermentation agent.
O Cebrim Responde
Authors: CFF Cebrim
Published: December 2021

O Cebrim Responde
[Review] Felice Cimatti and Carlo Salzani, editors. Animality in Contemporary Italian Philosophy. Palgrave Macmillan Animal Ethics Series. Cham: Palgrave Macmillan, 2020. 341 pp.
Authors: Calarco Matthew
Published: December 2021

Animal Studies Journal 2021 10(2): [Review] Felice Cimatti and Carlo Salzani, editors. Animality in Contemporary Italian Philosophy. Palgrave Macmillan Animal Ethics Series. Cham: Palgrave Macmillan, 2020. 341 pp.
Текстове представлення українських переселенських говірок Башкортостану: емпірична база й теоретичне осмислення
Authors: Ткачук Марина
Published: December 2021

Статтю присвячено характеристиці корпусу фонозаписів переселенських українських говірок с. Золотоношка Стерлітамакського району та с. Степанівка Аургазинського району Республіки Башкортостан (РФ), які зберігаються в Інституті української мови НАН України і на підставі яких створюється зібрання транскрибованих діалектних текстів як емпірична база діалектологічних досліджень. Схарактеризовано їхню діалектну основу, напрямки переселення людності, тематичне розмаїття наративів, що входять у таку текстову базу. Увагу приділено характеристиці соціокомунікативних умов в українських громадах у Башкортостані та особливостям експлорації носіїв говірок. Описано деякі риси цих говірок на фонетичному, морфологічному та лексичному рівнях.
Formy oboczne miejscownika liczby pojedynczej (w) domu – (w) domie w gwarach polskich na Litwie
Authors: Karaś Halina
Published: December 2021

W niniejszym artykule omówiono oboczne formy miejscownika liczby pojedynczej rzeczownika męskiego dom: (w) domu – (w) domie (a więc zgodną z normą ogólnopolską i analogiczną, powstałą w wyniku wyrównania końcówki fleksyjnej do pozostałych rzeczowników męskich twardotematowych) w gwarach polskich na Litwie, ich zakres i zasięg oraz frekwencję. Podstawą materiałową rozważań jest zbiór 235 form miejscownika lp. rzeczownika dom (domu, domie) i 3 przykładyformy doma wyekscerpowane z nagrań dokonanych w 4 podstawowych enklawach polskojęzycznych, tj. na obszarze ignalińskim, jezioroskim, kowieńskim i wileńskim.
Символ – значення – словник: шляхи інтерпретації
Authors: Сімович Оксана
Published: December 2021

Вербальний символ – це багатопланова відкрита семантична структура, що має здатність в одному контексті виявляти кілька символічних значень одночасно. Проблеми лексикографічної фіксації та, відповідно, визначення семантики символу зумовлена його складною внутрішньою природою, неоднозначністю тлумачення, залежністю інтерпретації від індивідуального прочитання тексту та символу в ньому. Кожне нове прочитання навіть того самого чи іншого тексту викликатиме нові асоціації та нову інтерпретацію, залучатиме до цього процесу інші тексти й символи. Дослідження присвячено проблемам лексикографічної фіксації традиційних вербальних символів. Найбільше можливостей мають словники обрядової лексики, у яких за описом слова часто прихований символічний зміст.
Локальні маркери в українських пам’ятках офіційно-ділового стилю другої половини XVII–XVIII ст
Authors: Grytsenko Svitlana
Published: December 2021

Статтю присвячено дослідженню локальних маркерів у писемних пам’ятках офіційноділового стилю другої половини XVII–XVIII ст., окресленню тенденцій розвитку староукраїнської мови цього періоду. Джерельну базу пропонованої розвідки формують ділові документи з Гуцульщини другої половини XVIII ст., зібрані О. Маковеєм і представлені М. Грушевським на ІІ асіданні «історично-фільософічної секції» Наукового товариства імені Шевченка у Львові (1909 р.) та акти Лохвицької ратушної книги другої половини XVII ст. Встановлено, що попри усталений віками структурний каркас ділових пам’яток, вони репрезентують елементи живого народного мовлення, що відображені найяскравіше в основній частині документа, де викладено суть справи. Наголошено, що дослідження українського мовного простору у діахронії крізь призму писемних пам’яток офіційно-ділового стилю актуалізує потребу реалізації новітніх лексикографічних студій з урахуванням сучасних форм комп’ютерного опрацювання текстів та удоступнення їх широкому загалу, створенням нової методології словникових студій, нових типів лексиконів.
Linguistic geography and historical material. An example of inventory ledgers from the second half of the 18th century kept in Wielkopolska
Authors: Osowski Błażej
Published: December 2021

This work connects with the dialectological aspect of linguistic geography. The analysed material consists of inventory ledgers kept in Wielkopolska in the second half of the 18th century for nobility possessions. It is assumed that the then regional variety of the Polish language spoken in Wielkopolska was geographically diverse and this diversity was anything but accidental. It was affected by the education of the communication actors (including the writers) and their command of the literary Polish language, dialectal influences, impact of foreign languages, presence of archaic and innovative elements. This diversity is reflected in inventory ledgers; an analysis thereof was aimed at excerpting examples of lexical variants. This work contains 4 selected examples: ‘bogaty chłop’ [a wealthy farmer], ‘ziemniaki’ [potatoes], ‘mała izba’[a small room], ‘niebieski’ [blue]. Maps have been created for them. The analytical part is followed by generalisation of the variability in the surveyed sources (types of variability, its sources, levels, types of variants).
Time Optimal Control Studies on COVID-19 Incorporating Adverse Events of the Antiviral Drugs
Authors: Chhetri Bishal , Bhagat Vijay M. , Muthusamy Swapna , Ananth V S , Vamsi D. K. K. , Sanjeevi Carani B
Published: December 2021

COVID -19 pandemic has resulted in more than 257 million infections and 5.15 million deaths worldwide. Several drug interventions targeting multiple stages of the pathogenesis of COVID -19 can significantly reduce induced infection and thus mortality. In this study, we first develop SIV model at within-host level by incorporating the intercellular time delay and analyzing the stability of equilibrium points. The model dynamics admits a disease-free equilibrium and an infected equilibrium with their stability based on the value of the basic reproduction number R
0. We then formulate an optimal control problem with antiviral drugs and second-line drugs as control measures and study their roles in reducing the number of infected cells and viral load. The comparative study conducted in the optimal control problem suggests that if the first-line antiviral drugs show adverse effects, considering these drugs in reduced amounts along with the second-line drugs would be very effective in reducing the number of infected cells and viral load in a COVID-19 infected patient. Later, we formulate a time-optimal control problem with the goal of driving the system from any initial state to the desired infection-free equilibrium state in finite minimal time. Using Pontryagin’s Minimum Principle, it is shown that the optimal control strategy is of the bang-bang type, with the possibility of switching between two extreme values of the optimal controls. Numerically, it is shown that the desired infection-free state is achieved in a shorter time when the higher values of the optimal controls. The results of this study may be very helpful to researchers, epidemiologists, clinicians and physicians working in this field.
Zum Modalverbeinsatz in Einleitungen von Dissertationen aus unterschiedlichen Fachbereichen
Authors: Hinzmann Friederike
Published: December 2021

In diesem Beitrag wird der Einsatz von Modalverben (MV) in Einleitungen von Dissertationen aus unterschiedlichen Fachbereichen untersucht. Anhand dieses Materials wird gezeigt, dass der Einsatz von MV einerseits im Zusammenhang mit für die Dissertation als typisch zu charakterisierenden Handlungen steht, andererseits aber auch MV-Verwendungen auszumachen sind, die nur unter Rückgriff auf fachliches Wissen zu rekonstruieren sind und daher komplexe leserseitige Deutungsleistungen erfordern, die für eine Didaktik dieser sprachlichen Mittel im Zusammenhang des Deutschen als fremder Wissenschaftssprache zu berücksichtigen sind.
Application of nanotechnologies along the food supply chain
Authors: Cruz-Lopes Luísa , Macena Morgana , Guiné Raquel P. F.
Published: December 2021

Nanoscience and nanotechnology are new frontiers for this century. Nanotechnology translates into the ability to manipulate the material on a nanoscale. As in other sectors, recent developments in the field of nanoscience and nanotechnology offer new opportunities for innovation for food. Nanofoods are considered foods grown, produced, processed or packaged using nanotechnological tools that incorporate nanomaterials to improve nutritional quality, taste or texture, and increase the shelf life of food. Nanotechnology’s applications are diverse, going from nanoencapsulated ingredients, such as bioactive compounds, nutrients and food additives that increase the bioavailability of the compounds, to ingredients that constitute nanostructures and nanotextures that provide barriers for physical-chemical protection, which allow modification of flavour and odour. Also, has the potential to be used as biosensors to monitor food conditions during storage and transport, through packaging that includes indicators. This review covers the development and use of nanotechnology along the food supply chain, focusing the agricultural production, industrial processing and protection through packaging, as well as addressing the advantages and disadvantages of using this technology.
Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype
Authors: Hansen Lena , Lohfink Niklas , Vutukuri Rajkumar , Kestner Roxane-Isabelle , Trautmann Sandra , Hecht Max , Wagner Pia Viktoria , Spitzer Daniel , Khel Maryam Ibrahim , Macas Jadranka , Ferreirós Nerea , Gurke Robert , Günther Stefan , Pfeilschifter Waltraud , Devraj Kavi
Published: December 2021

The precise regulation of blood-brain barrier (BBB) permeability for immune cells and blood-borne substances is essential to maintain brain homeostasis. Sphingosine-1-phosphate (S1P), a lipid signaling molecule enriched in plasma, is known to affect BBB permeability. Previous studies focused on endothelial S1P receptors 1 and 2, reporting a barrier-protective effect of S1P1 and a barrier-disruptive effect of S1P2. Here, we present novel data characterizing the expression, localization, and function of the S1P receptor 4 (S1P4) on primary brain microvascular endothelial cells (BMECs). Hitherto, the receptor was deemed to be exclusively immune cell associated. We detected a robust expression of S1P4 in homeostatic murine BMECs (MBMECs), bovine BMECs (BBMECs), and porcine BMECs (PBMECs) and pinpointed its localization to abluminal endothelial membranes via immunoblotting of fractionated brain endothelial membrane fragments. Apical S1P treatment of BMECs tightened the endothelial barrierin vitro, whereas basolateral S1P treatment led to an increased permeability that correlated with S1P4 downregulation. Likewise, downregulation of S1P4 was observed in mouse brain microvessels (MBMVs) after stroke, a neurologic disease associated with BBB impairment. RNA sequencing and qPCR analysis of BMECs suggested the involvement of S1P4 in endothelial homeostasis and barrier function. Using S1P4 knock-out (KO) mice and S1P4 siRNA as well as pharmacological agonists and antagonists of S1P4 bothin vitroandin vivo, we demonstrate an overall barrier-protective function of S1P4. We therefore suggest S1P4 as a novel target regulating BBB permeability and propose its therapeutic potential in CNS diseases associated with BBB dysfunction.

SIGNIFICANCE STATEMENTMany neurologic diseases including multiple sclerosis and stroke are associated with blood-brain barrier (BBB) impairment and disturbed brain homeostasis. Sphingosine-1-phosphate receptors (S1PRs) are potent regulators of endothelial permeability and pharmacological S1PR modulators are already in clinical use. However, the precise role of S1P for BBB permeability regulation and the function of receptors other than S1P1 and S1P2 therein are still unclear. Our study shows both barrier-disruptive and barrier-protective effects of S1P at the BBB that depend on receptor polarization. We demonstrate the expression and novel barrier-protective function of S1P4 in brain endothelial cells and pinpoint its localization to abluminal membranes. Our work may contribute to the development of novel specific S1PR modulators for the treatment of neurologic diseases associated with BBB impairment.
Pouillon’s Practical Theory. A Design Method for Contemporary Architectural Practice
Authors: Mossa Emilio
Published: December 2021

The aim of this paper is to underline the currency and modernity of Fernand Pouillon’s method for contemporary architectural practices. In particular, this dissertation analyzes the theory hidden behind Pouillon’s practice, and the motivation influencing the final quality of his works in order to make this method implementable to the current conditions of architectural design related to the management of complexity, buildability and quality of buildings. This paper explains Pouillon’s design process through the case study of Résidence Les 200 Logements, or dwellings, built in Aix-en-Provence between 1951 and 1955. This work represents the turning point experience in the development of a design methodology that Pouillon will use for the following twenty years of his career. The 200 Logements project demonstrates the absolute effectiveness of this design method to achieve a certain quality in all the production phases. By merging technological and humanistic culture, the buildings designed by Pouillon exemplify the possibility of making theory through practice. Intended as “practical theories,” the models and the approaches proposed by Pouillon represent a design method that can still be used today.
PRECISIONES CONCEPTUALES, TEÓRICAS E HISTÓRICAS PARA UNA NOCIÓN INDISCIPLINADA DE LA ARQUITECTURA Y SU INVESTIGACION
Authors: Farrés Delgado Yasser
Published: December 2021

La necesidad de equiparar la producción de conocimiento en arquitectura con la producción en otras áreas, que surge en Colombia con el proceso de medición de grupos de investigación e investigadores de Colciencias/Minciencias,[1] parece haber dejado a un lado a la motivación por comprender las relaciones internas entre las sub-disciplinas de la arquitectura como elemento fundante de la naturaleza del conocimiento arquitectural. Frente a ello, este ensayo hace una revisión bibliográfica que recupera las nociones de arquitectura y sus sub-disciplinas conceptuadas por autores relevantes del contexto latino/latinoamericano y las pone en contacto con otras referencias. Se pretende argumentar que es necesario pensar la investigación en arquitectura más allá del concepto “investigación proyectual”.

[1] Colciencias es el acrónimo del antiguo Departamento Administrativo de Ciencias, Tecnología e Innovación, devenido en el actual Ministerio de Ciencias, Tecnología e Innovación (Minciencias)
Taha Abdurrahman. Dini Amel ve Aklın Yenilenmesi (trc. Mehmet Emin Güleçyüz). İstanbul: Pınar Yayınları, 2019, 296 sayfa.
Authors: ATEŞ Muhammet
Published: December 2021

Düşünce tarihinin her büyük dönemecinde yapısökümüne uğratılıp yeniden inşa edilen ya da en azından kapsamlı bir şekilde revize edilen “akıl”, ihtisas alanı mantık olan Taha Abdurrahman’ın fikrî takip alanına daha ilk eserlerinden itibaren girmiştir. Aklın izini büyük bir tecessüsle süren bu düşünsel etkinlik Taha Abdurrahman’ın yazdığı her eserde kendisine ya sarihen, yani metnin gövdesinde açıkça yer alarak ya da zımnen, yani metnin semantik bütünlüğünü sağlayan arka plandaki istidlal mekanizmasında müsellem kabuller olarak başat bir yer bulmuştur. Yetiştiği muhitteki Arap düşünürlere Descartes’ın inşa ettiği aklın hâkim olması Taha Abdurrahman’ı akıl ve rasyonaliteye yönelik köklü eleştiriler yapmaya ve yeni tezler ortaya atmaya sevk etmiştir.
Zekeriyya b. İsmail el-Yûsufî. el-Cevâbü’l-Latîf alâ Kitâbi’ş-Şeyh Muhammed Avvâme Hükmü’l-ameli bi’l-hadîsi’d-daîf. Kahire: Merkezü İhyâ li’l-Buhûs ve’d-Dirâsât, 1441/2020, 416 sayfa.
Authors: ÇAVUŞ Osman
Published: December 2021

Hadis usulünün güncelliğini koruyan konularından biri olan zayıf hadisin amele kaynaklığı ve şer‘î delil oluşuyla ilgili tartışmalara Hükmü’l-amel bi’l-hadîsi’d-daîf beyne’n-nazariyye ve’t-tatbîk ve’d-daʻvâ adlı eseriyle katılan Muhammed Avvâme’ye göre mütekaddim âlimler zayıf hadisle ameli caiz, hatta müstehap görürler, zayıf hadisler kitaplara sadece nakletmek için değil amel edilmek için de kaydedilmiştir. İlk defa Şevkânî (ö. 1834) tarafından dillendirilen “zayıfla hiçbir şekilde amel edilemeyeceği” görüşünün Sıddîk Hasan Han (ö. 1890), Tâhir el-Cezâirî (ö. 1920), Ahmed Muhammed Şâkir (ö. 1958) ve Elbânî (ö. 1999) ile devam ettirildiğini belirten Avvâme, çalışmasında mütekaddim âlimlerin yolunu takip ederek “muasırların hatalı görüşleri”nden sakınacağını söyler.
ASSESSMENT OF THE ECONOMIC EFFECT OF ENERGY STORAGE SYSTEM PROVIDING THE BAL-ANCING SERVICES IN THE IPS OF UKRAINE
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,, Parus E.V. , Blinov I.V. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,, Olefir D.O. ,   PJSC "Ukrhydroenergo", Vyshhorod, 07300, Ukraine
Published: December 2021

The article presents a simulation model for estimating the economic effect of the energy storage systems providing the balancing electricity to the Transmission System Operator in the balancing market segment. The model simulates the serial charge and discharge of storage (i.e., sequential provision of unloading and loading services). Peculiarities of considering the cost of purchase, installation, and maintenance of energy storage systems with reduction both to the guaranteed service life and the guaranteed resource of charge/discharge cycles are given. An example of the application of the simulation model for estimating the economic effect and payback period of energy storage systems in the provision of electricity balancing services in the balancing market segment is shown. Ref. 15.
ANALYSIS OF METHODS OF INCREASING DATA RELIABILITY FOR PROBLEMS OF SHORT TERM FORECASTING OF NODAL LOAD
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,, Shymaniuk P.V. , Miroshnyk V.O. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,
Published: December 2021

A comparative analysis of clustering methods was performed to identify gaps and anomalous values in the data. Data from the northwestern region of the United States were used for evaluation. According to the analysis results, it was found that the use of the DBSCAN method leads to a much smaller number of false positives. An algorithm for two-stage data validation using clustering and time series decomposition methods is proposed. Ref.9, fig. 3, tables 3.
PRINCIPLES OF IMPROVEMENT OF MULTILEVEL AUTONOMOUS VOLTAGE INVERTERS
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,, Volkov I.V. , Golubev V.V. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,, Zozulev V.I. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, pr. Peremohy, 56, Kyiv, 03057, Ukraine,
Published: December 2021

The article considers the properties of the most commonly used two-and multilevel inverter topologies used in systems for converting electricity from several primary power sources into the required high-quality output voltage for low-voltage networks and high-voltage consumers. However, a common disadvantage of most known multilevel converters is the increasing complexity of power structures, an increase in the number of primary power sources, power elements, and the cost of devices as the number of their voltage levels increases. Two schemes of alternative three-level autonomous voltage inverters with a high-frequency autotransformer with a midpoint and an example of constructing their digital control system are proposed. The analysis of their work on PSpice models in the OrCAD design system is carried out. The possibility of obtaining six voltage sublevels with fewer power elements and increased output voltage quality is shown, compared to the corresponding cascade multilevel inverters. The advantages and applications of autotransformer bridge voltage inverters in terms of energy and functionality compared to well-known multilevel inverters are presented. Ref. 8, fig. 7.
Phase diagram of the selfinteracting particle­-antiparticle boson system
Authors: Anchishkin D. , Gnatovskyy V. , Zhuravel D. , Karpenko V.
Published: December 2021

A system of interacting relativistic bosons at finite temperatures and isospin densities is studied within the framework of the Skyrme­like mean­field model. The mean field contains both attractive and repulsive terms. The consideration is taken within the framework of the Canonical Ensemble and the isospin­density dependencies of thermodynamic quantities is obtained, in particular as the phase diagrams. It is shown that in such a system, in addition to the formation of a Bose­Einstein condensate, a liquid­gas phase transition is possible. We prove that the multi­boson system develops the Bose condensate for particles of high­density component only.
New heavy gauge bosons decaying to pair of electroweak bosons: prospect studies at Run 3 and HL-LHC with ATLAS
Authors: Serenkova I. A. , Pankov A. A. , Bednyakov V. A.
Published: December 2021

The expected ATLAS Run 3 data set with time-integrated luminosity of 300 fb-1 and HL-LHC option of the LHC with L = 3000 fb-1 in the diboson channels in semileptonic final states are used to probe a simple benchmark model with an extended gauge sector, proposed by Altarelli et al. This model accommodates new charged W' and neutral Z' vector bosons with modified trilinear Standard Model gauge couplings, decaying into electroweak gauge boson pairs WZ or WW , where W / Z decay semileptonically. We present upper limits on the mixing parameters, W - W' and Z- Z ' , by using the expected Run 3 data and HL-LHC options of the LHC.
Influence of chemical composition and the processing conditions on structure, thermal stability and mechanical properties of rapidly cooled Al-TM-RE-based alloys
Authors: Nosenko V. K. , Mika T. M. , Mashira V. A. , Kandaurov O. , Semirga O. M. , Bevz V. P.
Published: December 2021

The results of t studies are directed to development of new competitive amorphous and nanocrystalline alloys as well as to improvement of technology of their manufacturing. The physical and technological aspects of interrelations between the conditions for production of rapidly quenched alloys, formation of different structural and phase states, and their properties are discussed. The influence of the chemical composition of alloys and the conditions of their quenching on the glass-forming ability, phase composition, and the structure of the rapidly cooled specimens is investigated; the regularities of the effect of alloying elements concentration on the structural features of the Al75–87(Ni,Co,B/Ga)8–20Gd1Y4 alloys obtained by superfast quenching from the liquid state are established. The thermal stability of the rapidly quenched ribbons with an amorphous structure is investigated and the temperature ranges of phase transformations at continuous heating and under isothermal conditions are found. The strength characteristics of the ribbons as a function of the content and nature of alloying elements as well as the melt cooling rate are determined. The methods of obtaining both Al-based bulk nanocrystalline composites with the shapes of rods and plates with thickness of 0.5–3.5 mm and metal matrix hardening coatings are worked out.
Conditions for partial and complete crystallization suppression upon quenching from liquid state
Authors: Lysenko O. B. , Kalinina T. V. , Zagorulko I. V.
Published: December 2021

For bulk-amorphizing alloys Мg65Сu25Y10 and Zr41,2 Тi13,8Сu12,5Ni10Ве22,5, the thickness and cooling rate of melt layers is calculated, which ensure the formation of X-ray amorphous structures typical for metallic glasses ( lC, vC ), and truly amorphous states without inclusions of «frozen-in crystallization centers» (lc*, vc* ). Correlation of the calculated values lC, vC with the known experimental estimates is C Cachieved. It is shown that both studied alloys demonstrate a predisposition to complete suppression of crystallization processes at physically correct values of the parameters lc* and vc* (10 μm; 1,3·107 K/s and 550 μm; 2,7·103 K/s for alloys based on Mg and Zr, respectively). It is concluded that the most significant factors controlling the tendency of materials to noncrystalline solidification are the decrease in the frequency of non-stationary nucleation with the increase in the rate of QLS, as well as relatively low <1018 m-3 s-1) maximum values of the rate of stationary crystallization centers formation.
Thermodynamic and kinetic features of the formation of amorphous state in films during quenching from the vapor state
Authors: Bashev V. F. , Ryabtsev S. I. , Dotsenko F. F.
Published: December 2021

The method of modernized ion-plasma sputtering produced metastable states, including nanocrystalline and amorphous phases in films, even in alloys whose components do not mixed in the liquid state. The effective rate of energy relaxation at different modes of precipitation is theoretically estimated to be 1012 -1014 K/s during ion-plasma sputtering of atoms. On thermodynamic and kinetic states, different active and passive parameters for amorphization during sputtering are analyzed. The receiving expressions are in good agreement with the experimental results and contribute to the determination of further steps to obtain an amorphous state.
Multi-component nitrated ion-plasma Ni-Cr coating
Authors: Nadtoka V. , Kraiev M. , Borisenko A. , Kraieva V.
Published: December 2021

Method for ion-plasma deposition is applied for covering of heat-resistant Ni-Cr alloy XH78T. Coating deposition is performed under nitrogen gas atmosphere at the pressure from 3×10-5 to 1×10-2 Torr. The nitrogen content in the coating is reached up to 2,7 %. Nitrated coatings with a thickness of 184-222 μm is obtained without embrittlement and with a uniform distribution of microhardness. The effect of the nitrogen pressure in a vacuum chamber on the structure of the coatings, which changes from homogeneous to columnar with conical crystallites, is presented. Nitration increases microhardness of the coatings from 3669 to 7575 HV, the wear resistance of the coatings increases by 6-8 times. The received coatings can be used to increase the durability of metallurgical equipment parts.
Optical absorption of LiNaGe4O9:Mn crystal
Authors: Osetsky A. Yu. , Panchenko T. V. , Volnianskii M. D. , Trubitsyn M. P.
Published: December 2021

The paper reports the results of optical absorption spectra studying in LiNaGe4O9 crystal doped with Mn. It is shown that Mn impurity causes the appearance of the additional absorption bands. The intensities of these bands change in different ways in the range of the ferroelectric phase transition. Semi-empirical version of the crystal field theory is used to discuss localization and charge state of Mn impurity ions in the LiNaGe4O9 structure.
Vacancies in the molecular crystal of 2-(2'-hydroxyphenyl)benzothiazole
Authors: Syetov Y.
Published: December 2021

Structure of molecular units is calculated for the periodic model corresponding to the crystal lattice of 2-(2'-hydroxyphenyl)benzothiazole with vacancies. 2-(2' -hydroxyphenyl)benzothiazole is a luminescent organic substance undergoing excited state intramolecular proton transfer. The calculations are performed with density-functional based tight-binding methods usding Van der Waals interaction empirical correction. It is found that the dihedral angles formed by benzothiazole and phenol parts of the molecules deviate in the vicinity of the vacancy. The vacancy provides enough space for non-planar conformation of the molecules in the ground state. At the same time the increase in energy of the periodic structure with the vacancies caused by appearance of the non-planar conformation is larger than the corresponding increase in the isolated molecule.