bluuebunny/crossref_metadata_2025 huggingface dataset:
New Insight of Maximum Transferred Power by Matching Capacitance of a Wireless Power Transfer System
Authors: Xiao Chunyan , Liu Yufeng , Cheng Dingning , Wei Kangzheng
Published: May 2017

Most research on wireless power transfer (WPT) has been focused on how to achieve a high-efficiency power transfer. Our study found that under the impedance matching for achieving maximum WPT efficiency, the power transferred to the load cannot reach the maximum when a WPT system is supplied by an AC voltage source with constant amplitude. However, the load power or the voltage across the load is essential for a low-power electric device such as the implanted medical device where the transfer efficiency is not the priority to be considered. The paper presents a method for achieving maximum power on the load by matching capacitance in a WPT system with given two-coupled-coils. Three sets of matching capacitances for extreme load power were deduced based on the circuit model considering the coil's resistance, and all these three matching make the WPT system operate at the resonant state. Two sets can make the system achieve the global maximum of load power. One set can make the system achieve the local maximum of load power and reach the power transfer efficiency next to 1. Experimental results verified the theoretical calculations. The results can contribute to the compensation design of a practical WPT system for transferring the maximum power to the load.
An On-Board Remaining Useful Life Estimation Algorithm for Lithium-Ion Batteries of Electric Vehicles
Authors: Li Xiaoyu , Shu Xing , Shen Jiangwei , Xiao Renxin , Yan Wensheng , Chen Zheng
Published: May 2017

Battery remaining useful life (RUL) estimation is critical to battery management and performance optimization of electric vehicles (EVs). In this paper, we present an effective way to estimate RUL online by using the support vector machine (SVM) algorithm. By studying the characteristics of the battery degradation process, the rising of the terminal voltage and changing characteristics of the voltage derivative (DV) during the charging process are introduced as the training variables of the SVM algorithm to determine the battery RUL. The SVM is then applied to build the battery degradation model and predict the battery real cycle numbers. Experimental results prove that the built battery degradation model shows higher accuracy and less computation time compared with those of the neural network (NN) method, thereby making it a potential candidate for realizing online RUL estimation in a battery management system (BMS).
Presentation and Performance Evaluation of a Novel Stator-Permanent-Magnet Hybrid Stepping Motor
Authors: Lu Binglin , Xu Yanliang
Published: May 2017

In this paper, a new type of hybrid stepping motor (HSM) with permanent magnets (PMs) embedded in the stator, namely the stator-permanent-magnet hybrid stepping motor (SHSM), is presented. It has the same operation principles as the traditional HSM, with a 2-D distributed magnetic field nature and superiorities such as simpler rotor structure, easier PM cooling, higher torque and power density, and higher power grade. Its structural topology and operation principles are initially presented. Then an investigation on the performance comparison between the HSM and the SHSM, in terms of PM flux density, PM torque, detent torque, positional holding accuracy, stator core saturation issue, PM flux leakage, and PM utilization rate is carried out theoretically to make an assessment of the performance superiorities of the SHSM. A prototype of a 2-phase 8-pole 50-rotor-tooth SHSM is fabricated and experimentally compared with the HSM by using finite element analysis (FEA) to verify the motor’s operational feasibility and the theoretical analysis. The FEA and experimental results show that the proposed SHSM has performance advantages such as higher torque density, higher power grade, and higher pull-out torque, holding torque, and torque-speed property, although it has performance defects such as higher torque ripple and relatively lower positional holding accuracy in the open-loop operation than the conventional HSM. Consequently, this novel SHSM is more suitable for electromechanical energy conversion applications rather than positioning mechanisms, especially taking into account the open-loop control advantage.
Influence of Prewhirl Angle and Axial Distance on Energy Performance and Pressure Fluctuation for a Centrifugal Pump with Inlet Guide Vanes
Authors: Liu Yabin , Tan Lei , Liu Ming , Hao Yue , Xu Yun
Published: May 2017

The energy performance and pressure fluctuations in a centrifugal pump with inlet guide vanes (IGVs) are investigated experimentally and numerically in a prewhirl angle range of −24° to 24° and in an axial distance range of 280 mm, 380 mm, and 460 mm. The reliability and accuracy of the numerical method are validated by the satisfactory agreement between the experimental data and numerical results. Prewhirl regulation with IGVs can significantly increase the energy performance and broaden the efficient operation range for the centrifugal pump due to the improvement of flow pattern at the impeller inlet. The prewhirl angle has an obvious impact on pump energy performance, and the maximum amplitudes of pressure fluctuations on the blade leading edge of the pressure and suction sides decrease by 69% and 89%, respectively. The axial distance has a slight impact on pump energy performance, but the maximum amplitudes of pressure fluctuations drop by 35.4% on the blade leading edge of pressure side when the axial distance extends from 280 mm to 460 mm.
Microbial Propionic Acid Production
Authors: Gonzalez-Garcia R. , McCubbin Tim , Navone Laura , Stowers Chris , Nielsen Lars , Marcellin Esteban
Published: May 2017

Propionic acid (propionate) is a commercially valuable carboxylic acid produced through microbial fermentation. Propionic acid is mainly used in the food industry but has recently found applications in the cosmetic, plastics and pharmaceutical industries. Propionate can be produced via various metabolic pathways, which can be classified into three major groups: fermentative pathways, biosynthetic pathways, and amino acid catabolic pathways. The current review provides an in-depth description of the major metabolic routes for propionate production from an energy optimization perspective. Biological propionate production is limited by high downstream purification costs which can be addressed if the target yield, productivity and titre can be achieved. Genome shuffling combined with high throughput omics and metabolic engineering is providing new opportunities, and biological propionate production is likely to enter the market in the not so distant future. In order to realise the full potential of metabolic engineering and heterologous expression, however, a greater understanding of metabolic capabilities of the native producers, the fittest producers, is required.
Distribution, Spread, and Habitat Predictability of a Small, Invasive, Piscivorous Fish in an Important Estuarine Fish Nursery
Authors: Greenwood M.
Published: May 2017

Invasive species often cause negative ecological and economic effects. Florida has >20 established invasive fish species but only seven exist in saltwater. The present study examined Belonesox belizanus (Pike Killifish), a Central American euryhaline fish introduced to Tampa Bay (west-central Florida) in the early 1990s, which has quantifiably reduced populations of small-bodied native fishes and may compete with prized sportfish juveniles in estuarine nursery habitat. Long-term monitoring revealed that B. belizanus occurs in estuarine waterbodies along a 31-km stretch of the bay’s eastern fringe, with a second, smaller population in two western tributaries. Spread rate was estimated to be 5.5–13 km year−1, intermediate among invasive poeciliids. A novel implementation of boosted regression tree modeling to assess B. belizanus habitat predictability found greater probability of presence with decreasing water depth and pH, whereas presence tended to be greatest at polyhaline salinity. It is hypothesized that B. belizanus distribution in Tampa Bay is constrained by deep, seawall habitats acting as ecological barriers. Further B. belizanus spread therefore may be most likely to occur by human release (from aquaria or bait buckets) or bird carry-off. Newly restored tidal habitat within the current range probably will be invaded quite quickly by B. belizanus.
Construction of Hamiltonian and Nambu Forms for the Shallow Water Equations
Authors: Blender Richard , Badin Gualtiero
Published: May 2017

A systematic method to derive the Hamiltonian and Nambu form for the shallow water equations using the conservation for energy and potential enstrophy is presented. Different mechanisms, such as vortical flows and emission of gravity waves, emerge from different conservation laws for total energy and potential enstrophy. The equations are constructed using exterior differential forms and self-adjoint operators, and result in the sum of two Nambu brackets—one for the vortical flow and one for the wave-mean flow interaction—and a Poisson bracket representing the interaction between divergence and geostrophic imbalance. The advantage of this approach is that the Hamiltonian and Nambu forms can here be written in a coordinate-independent form.
Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus
Authors: Ruzicka W. , Subburaju Sivan , Benes Francine
Published: May 2017

Identification of 108 genomic regions significantly associated with schizophrenia risk by the Psychiatric Genomics Consortium was a milestone for the field, and much work is now focused on determining the mechanism of risk associated with each locus. Within these regions, we investigated variability of DNA methylation, a low-level cellular phenotype closely linked to genotype, in two highly similar cellular populations sampled from the human hippocampus, to draw inferences about the elaboration of genotype to phenotype within these loci enriched for schizophrenia risk. DNA methylation was assessed with the Illumina HumanMethylation450 BeadArray in tissue laser-microdissected from the stratum oriens of subfield CA1 or CA2/3, regions having unique connectivity with intrinsic and extrinsic fiber systems within the hippocampus. Samples consisted of postmortem human hippocampus tissue from eight schizophrenia patients, eight bipolar disorder patients, and eight healthy control subjects. Within these genomic regions, we observed far greater difference in methylation patterns between circuit locations within subjects than in a single subregion between subjects across diagnostic groups, demonstrating the complexity of genotype to phenotype elaboration across the diverse circuitry of the human brain.
Times of Crisis, Seeds of Modernity: Women and Popular Revolts in Modern Spain
Authors: Muñoz-Muriana Sara
Published: May 2017

In the 18th century, nations began acknowledging the presence of those who belonged to inferior classes and regarding them as the constitutive political subject of the modern state. Paradoxically, even as these marginal individuals were turned into central figures of the state’s political apparatus, they plunged the notion of sovereignty into crisis as they questioned the status quo and embodied an alternative to institutional power. In this light, the present essay explores the idea of crisis and modernity in the Spanish context from a historical, spatial, and gendered perspective. Women occupy a central space as a minority collective at the margins of the citizenry. But with their action and participation in mutinies, wars and revolutions—all landmarks of state crisis—they make themselves visible and open new spaces of agency from which to disrupt and renew traditional norms. By analyzing 18th- and 19th-century newspaper articles, literary works, and a number of visual representations by Spanish painter Francisco de Goya, this essay will examine the power of art to reveal how crises allow women to emerge as political subjects and to rewrite a narrative of modernity in which they take the leading role in propelling social change, influencing projects of political citizenship, and shaping a modern nation that needs to tend to all its members, making evident that crisis, while a break in the established order, is also a liberating step towards emancipation.
Family Planning and the Samburu: A Qualitative Study Exploring the Thoughts of Men on a Population Health and Environment Programme in Rural Kenya
Authors: Kock Loren , Prost Audrey
Published: May 2017

Population Health and Environment (PHE) strategies are argued to improve ecosystem and human health by addressing family size and its effects on natural resource use, food security, and reproductive health. This study investigates men’s views on a PHE family planning (FP) programme delivered among the pastoral Samburu tribe in rural northern Kenya. Three focus group discussions and nine semi-structured interviews were conducted with 27 Samburu men. These discussions revealed support for environmentally-sensitised family planning promotion. Men highlighted their dependency on natural resources and challenges faced in providing for large families and maintaining livestock during drought. These practices were said to lead to natural resource exhaustion, environmental degradation, and wildlife dispersal, undermining key economic benefits of environmental and wildlife conservation. Relating family size to the environment is a compelling strategy to improve support for FP among Samburu men. Kenyan policy-makers should consider integrating community-based PHE strategies among underserved pastoral groups living in fragile ecosystems.
Self-Management Group Exercise Extends Healthy Life Expectancy in Frail Community-Dwelling Older Adults
Authors: Yamada Minoru , Arai Hidenori
Published: May 2017

Preventing frailty and its adverse health outcomes is crucial in countries with a large elderly population, such as Japan. Since the long-term care insurance (LTCI) system was launched, the number of certified older adults with LTCI service requirement has continued to increase. This is a serious problem, because the LTCI service requirement certification is equivalent to disability. The aim of this study was to evaluate the effect of a self-management group intervention on new LTCI service requirement certifications in community-dwelling older adults in Japan. We analyzed the cohort data from a prospective study. In this study, we recruited community-dwelling adults aged 65 years and older who were independent in a city in Kyoto prefecture in 2012. The subjects in the participation group (n = 1620) attended 60-min group training sessions once or twice every two weeks from December 2012 to December 2016. The exercise sessions consisted of mild-intensity aerobic exercise, mild strength training, flexibility and balance exercises, and cool-down activities. These exercise classes were facilitated by well-trained volunteer staff. The outcome measure was the number of new LTCI requirement certifications during a four-year follow-up period. During the four-year follow-up period, 247 subjects (15.2%) in the participation group and 334 (20.6%) in the control group were newly certified for LTCI service requirements. The hazard ratio for new LTCI service requirements in the participation group compared with the control group was 0.73 (95% CI = 0.62–0.86) in the four-year follow-up period. These results indicate the usefulness of self-management group exercise to reduce the incidence of disability in older adults. Thus, increasing self-management group activities in each community should be encouraged.
Accuracy Assessment and Inter-Comparison of Eight Medium Resolution Forest Products on the Loess Plateau, China
Authors: Yang Zhiqi , Dong Jinwei , Liu Jiyuan , Zhai Jun , Kuang Wenhui , Zhao Guosong , Shen Wei , Zhou Yan , Qin Yuanwei , Xiao and Xiangming
Published: May 2017

Forests play an important role in maintaining ecosystem services, especially in ecologically fragile areas such as the Loess Plateau (LP) in China. However, there is still great uncertainty in the spatial extent and distribution of forests in such a fragmented region. In order to examine the advantages and disadvantages of existing forest mapping products, we conducted a thorough accuracy assessment on the eight recent, medium resolution (30–50 m) products by using the LP in 2010 as the region of interest. These mapping products include Landsat and/or PALSAR images (including the forest products from GlobeLand30), FROM-GLC, Hansen, ChinaCover, NLCD-China, GLCF VCF, OU-FDL, and JAXA. The same validation data were used to assess and rank the accuracy of each product. Additionally, the spatial consistency of the different forest products and their dependence on the terrain were analyzed. The results showed that the overall accuracies of the eight forest products on the LP in 2010 were between 0.93 ± 0.003 and 0.97 ± 0.002 with a 95% confidence interval, and GlobeLand30 presented the highest overall accuracy (0.97 ± 0.002). Among them, the PALSAR-based products (OU-FDL and JAXA) indicated relatively high accuracies, while the six Landsat-based products showed a large diversity in the accuracy. According to the eight products, the total estimated forest area of the LP varied from 7.627 ± 0.077 to 10.196 ± 0.1 million ha with a 95% confidence interval. We also found that the consistency in the spatial distribution of forests between these maps: 1) increased substantially with increasing elevation until 2000m, but then decreased at higher elevations, and 2) showed mild variation along increasing slope, but had a slight rate of increase. Our findings implied that future forest mapping studies should consider topographical attributes such as elevation and slope in their final products. Our results are fundamental in guiding future applications of these existing forest maps.
Molecular Pathways Involved in the Amelioration of Myocardial Injury in Diabetic Rats by Kaempferol
Authors: Suchal Kapil , Malik Salma , Khan Sana , Malhotra Rajiv , Goyal Sameer , Bhatia Jagriti , Ojha Shreesh , Arya Dharamvir
Published: May 2017

There is growing evidence that chronic hyperglycemia leads to the formation of advanced glycation end products (AGEs) which exerts its effect via interaction with the receptor for advanced glycation end products (RAGE). AGE-RAGE activation results in oxidative stress and inflammation. It is well known that this mechanism is involved in the pathogenesis of cardiovascular disease in diabetes. Kaempferol, a dietary flavonoid, is known to possess antioxidant, anti-apoptotic, and anti-inflammatory activities. However, little is known about the effect of kaempferol on myocardial ischemia-reperfusion (IR) injury in diabetic rats. Diabetes was induced in male albino Wistar rats using streptozotocin (70 mg/kg; i.p.), and rats with glucose level >250 mg/dL were considered as diabetic. Diabetic rats were treated with vehicle (2 mL/kg; i.p.) and kaempferol (20 mg/kg; i.p.) daily for a period of 28 days and on the 28th day, ischemia was produced by one-stage ligation of the left anterior descending coronary artery for 45 min followed by reperfusion for 60 min. After completion of surgery, rats were sacrificed and the heart tissue was processed for biochemical, morphological, and molecular studies. Kaempferol pretreatment significantly reduced hyperglycemia, maintained hemodynamic function, suppressed AGE-RAGE axis activation, normalized oxidative stress, and preserved morphological alterations. In addition, there was decreased level of inflammatory markers (tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and NF-κB), inhibition of active c-Jun N-terminal kinase (JNK) and p38 proteins, and activation of Extracellular signal regulated kinase 1/2 (ERK1/2) a prosurvival kinase. Furthermore, it also attenuated apoptosis by reducing the expression of pro-apoptotic proteins (Bax and Caspase-3), Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells, and increasing the level of anti-apoptotic protein (Bcl-2). In conclusion, kaempferol attenuated myocardial ischemia-reperfusion injury in diabetic rats by reducing AGE-RAGE/ mitogen activated protein kinase (MAPK) induced oxidative stress and inflammation.
Determination of Genes Related to Uveitis by Utilization of the Random Walk with Restart Algorithm on a Protein–Protein Interaction Network
Authors: Lu Shiheng , Yan Yan , Li Zhen , Chen Lei , Yang Jing , Zhang Yuhang , Wang Shaopeng , Liu Lin
Published: May 2017

Uveitis, defined as inflammation of the uveal tract, may cause blindness in both young and middle-aged people. Approximately 10–15% of blindness in the West is caused by uveitis. Therefore, a comprehensive investigation to determine the disease pathogenesis is urgent, as it will thus be possible to design effective treatments. Identification of the disease genes that cause uveitis is an important requirement to achieve this goal. To begin to answer this question, in this study, a computational method was proposed to identify novel uveitis-related genes. This method was executed on a large protein–protein interaction network and employed a popular ranking algorithm, the Random Walk with Restart (RWR) algorithm. To improve the utility of the method, a permutation test and a procedure for selecting core genes were added, which helped to exclude false discoveries and select the most important candidate genes. The five-fold cross-validation was adopted to evaluate the method, yielding the average F1-measure of 0.189. In addition, we compared our method with a classic GBA-based method to further indicate its utility. Based on our method, 56 putative genes were chosen for further assessment. We have determined that several of these genes (e.g., CCL4, Jun, and MMP9) are likely to be important for the pathogenesis of uveitis.
Melatonin Secretion Is Increased in Children with Severe Traumatic Brain Injury
Authors: Marseglia Lucia , D’Angelo Gabriella , Manti Sara , Rulli Immacolata , Salvo Vincenzo , Buonocore Giuseppe , Reiter Russel , Gitto Eloisa
Published: May 2017

Background: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Oxidative stress plays a significant role in brain damage and melatonin exhibits both direct and indirect antioxidant effects. The primary aim of the present study was to evaluate serum melatonin levels in children with severe TBI in comparison to critically ill children admitted to the Pediatric Intensive Care Unit for conditions other than TBI. Methods: Twenty-four children were evaluated, equally divided into severe TBI and no-TBI. Blood samples for serum melatonin analysis were collected at 22:00, 01:00, 03:00, 05:00, 08:00, and 12:00. Results: Mean serum melatonin peaks in children of the TBI group were higher compared to the values of no-TBI critically ill children (495 ± 102 vs. 294 ± 119 pg/mL, p = 0.0002). Furthermore, the difference was even more significant in comparison to values reported in literature for healthy age-matched children (495 ± 102 vs. 197 ± 71 pg/mL, p < 0.0001). Conclusion: This study has shown that endogenous serum melatonin levels dramatically increase in children after severe TBI. This elevation is likely to represent a response to oxidative stress and/or inflammation due to severe head injury.
First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment
Authors: Jafari Paris , Muller Camillo , Grognuz Anthony , Applegate Lee , Raffoul Wassim , Di Summa Pietro , Durand Sébastien
Published: May 2017

Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the response to tissue loss from a wound repair process towards regeneration. When analyzing by Immunoassay the wound exudate from occlusive dressings, the concentrations of brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were higher in fingertip exudates than in burn wounds (used as controls for wound repair versus regeneration). Vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor (PDGF) were highly expressed in both samples in comparable levels. In our study, pro-inflammatory cytokines were relatively higher expressed in regenerative fingertips than in the burn wound exudates while chemokines were present in lower levels. Functional, vascular and mechanical properties of the regenerated fingertips were analyzed three months after trauma and the data were compared to the corresponding fingertip on the collateral uninjured side. While sensory recovery and morphology (pulp thickness and texture) were similar to uninjured sides, mechanical parameters (elasticity, vascularization) were increased in the regenerated fingertips. Further studies should be done to clarify the importance of inflammatory cells, immunity and growth factors in determining the outcome of the regenerative process and its influence on the clinical outcome.
Molecular Characterization and Expression Profiling of Tomato GRF Transcription Factor Family Genes in Response to Abiotic Stresses and Phytohormones
Authors: Khatun Khadiza , Robin Arif Hasan Khan , Park Jong-In , Nath Ujjal Kumar , Kim Chang Kil , Lim Ki-Byung , Nou Ill Sup , Chung Mi-Young
Published: May 2017

Growth regulating factors (GRFs) are plant-specific transcription factors that are involved in diverse biological and physiological processes, such as growth, development and stress and hormone responses. However, the roles of GRFs in vegetative and reproductive growth, development and stress responses in tomato (Solanum lycopersicum) have not been extensively explored. In this study, we characterized the 13 SlGRF genes. In silico analysis of protein motif organization, intron–exon distribution, and phylogenetic classification conﬁrmed the presence of GRF proteins in tomato. The tissue-specific expression analysis revealed that most of the SlGRF genes were preferentially expressed in young and growing tissues such as flower buds and meristems, suggesting that SlGRFs are important during growth and development of these tissues. Some of the SlGRF genes were preferentially expressed in fruits at distinct developmental stages suggesting their involvement in fruit development and the ripening process. The strong and differential expression of different SlGRFs under NaCl, drought, heat, cold, abscisic acid (ABA), and jasmonic acid (JA) treatment, predict possible functions for these genes in stress responses in addition to their growth regulatory functions. Further, differential expression of SlGRF genes upon gibberellic acid (GA3) treatment indicates their probable function in ﬂower development and stress responses through a gibberellic acid (GA)-mediated pathway. The results of this study provide a basis for further functional analysis and characterization of this important gene family in tomato.
New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer’s Disease
Authors: Fuchsberger Tanja , Lloret Ana , Viña Jose
Published: May 2017

The E3 ubiquitin ligase Anaphase Promoting Complex/Cyclosome (APC/C) regulates important processes in cells, such as the cell cycle, by targeting a set of substrates for degradation. In the last decade, APC/C has been related to several major functions in the nervous system, including axon guidance, synaptic plasticity, neurogenesis, and neuronal survival. Interestingly, some of the identified APC/C substrates have been related to neurodegenerative diseases. There is an accumulation of some degradation targets of APC/C in Alzheimer’s disease (AD) brains, which suggests a dysregulation of the protein complex in the disorder. Moreover, recently evidence has been provided for an inactivation of APC/C in AD. It has been shown that oligomers of the AD-related peptide, Aβ, induce degradation of the APC/C activator subunit cdh1, in vitro in neurons in culture and in vivo in the mouse hippocampus. Furthermore, in the AD mouse model APP/PS1, lower cdh1 levels were observed in pyramidal neurons in CA1 when compared to age-matched wildtype mice. In this review, we provide a complete list of APC/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models. Finally, we discuss the role of APC/C in the pathophysiology of AD.
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice
Authors: Ishigamori Rikako , Komiya Masami , Takasu Shinji , Mutoh Michihiro , Imai Toshio , Takahashi Mami
Published: May 2017

Osteopontin (OPN) is a secreted phosphoglycoprotein, and is a transcriptional target of aberrant Wnt signaling. OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression. In this study, the effect of deficiency of OPN on intestinal tumor development in Apc-deficient Min mice was investigated. At 16 weeks of age, the number of small intestinal polyps in Min/OPN(+/−) and Min/OPN(−/−) mice was lower than that of Min/OPN(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN(+/−) and Min/OPN(−/−) mice were significantly lower than those in Min/OPN(+/+) mice, being 48% and 0.6 ± 0.8, 50% and 0.8 ± 0.9 vs. 80% and 1.6 ± 1.7, respectively. OPN expression in colorectal tumors was strongly upregulated in Min/OPN(+/+) compared to adjacent non-tumor parts, but was decreased in Min/OPN(+/−) and not detected in Min/OPN(−/−). Targets of OPN, matrix metalloproteinases (MMPs)-3, -9, and -13 were lowered by OPN deficiency. Macrophage marker F4/80 in colorectal tumors was also lowered by OPN deficiency. MMP-9 expression was observed in tumor cells and tumor-infiltrating neutrophils. These results indicate that induction of OPN by aberrant Wnt signaling could enhance colorectal tumor development in part by upregulation of MMP-3, -9, and -13 and infiltration of macrophage and neutrophils. Suppression of OPN expression could contribute to tumor prevention, but complete deficiency of OPN may cause some adverse effects.
Human Chorionic Gonadotropin: The Pregnancy Hormone and More
Authors: Theofanakis Charalampos , Drakakis Petros , Besharat Alexandros , Loutradis Dimitrios
Published: May 2017

To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials.
Dynamic, Interactive and Visual Analysis of Population Distribution and Mobility Dynamics in an Urban Environment Using the Mobility Explorer Framework
Authors: Peters-Anders Jan , Khan Zaheer , Loibl Wolfgang , Augustin Helmut , Breinbauer Arno
Published: May 2017

This paper investigates the extent to which a mobile data source can be utilised to generate new information intelligence for decision-making in smart city planning processes. In this regard, the Mobility Explorer framework is introduced and applied to the City of Vienna (Austria) by using anonymised mobile phone data from a mobile phone service provider. This framework identifies five necessary elements that are needed to develop complex planning applications. As part of the investigation and experiments a new dynamic software tool, called Mobility Explorer, has been designed and developed based on the requirements of the planning department of the City of Vienna. As a result, the Mobility Explorer enables city stakeholders to interactively visualise the dynamic diurnal population distribution, mobility patterns and various other complex outputs for planning needs. Based on the experiences during the development phase, this paper discusses mobile data issues, presents the visual interface, performs various user-defined analyses, demonstrates the application’s usefulness and critically reflects on the evaluation results of the citizens’ motion exploration that reveal the great potential of mobile phone data in smart city planning but also depict its limitations. These experiences and lessons learned from the Mobility Explorer application development provide useful insights for other cities and planners who want to make informed decisions using mobile phone data in their city planning processes through dynamic visualisation of Call Data Record (CDR) data.
Estimating Density and Temperature Dependence of Juvenile Vital Rates Using a Hidden Markov Model
Authors: McElderry Robert
Published: May 2017

Organisms in the wild have cryptic life stages that are sensitive to changing environmental conditions and can be difficult to survey. In this study, I used mark-recapture methods to repeatedly survey Anaea aidea (Nymphalidae) caterpillars in nature, then modeled caterpillar demography as a hidden Markov process to assess if temporal variability in temperature and density influence the survival and growth of A. aidea over time. Individual encounter histories result from the joint likelihood of being alive and observed in a particular stage, and I have included hidden states by separating demography and observations into parallel and independent processes. I constructed a demographic matrix containing the probabilities of all possible fates for each stage, including hidden states, e.g., eggs and pupae. I observed both dead and live caterpillars with high probability. Peak caterpillar abundance attracted multiple predators, and survival of fifth instars declined as per capita predation rate increased through spring. A time lag between predator and prey abundance was likely the cause of improved fifth instar survival estimated at high density. Growth rates showed an increase with temperature, but the preferred model did not include temperature. This work illustrates how state-space models can include unobservable stages and hidden state processes to evaluate how environmental factors influence vital rates of cryptic life stages in the wild.
Laxative Effects of Dietary Supplementation with Sujiaonori Algal Biomaterial in Japanese Adult Women with Functional Constipation: A Case Study
Authors: Ngatu Nlandu , Ikeda Mitsunori , Watanabe Hiroyuki , Tanaka Mamoru , Inoue Masataka
Published: May 2017

Constipation is a gastrointestinal motility disorder that represents a major health problem in Japan. Approximately 26% of young Japanese adult women are reported to have this complaint. We report on the health effects of daily intake of Sujiaonori algal biomaterial (SBM) on constipation on 12 Japanese adult women. Data are from a four-week dietary intervention study on the health effects of daily Sujiaonori supplementation on cardiovascular, skin, and gastrointestinal health in which 32 adult Japanese volunteers (age range: 20–54 years) participated. They underwent clinical and laboratory investigations, and completed two study questionnaires (the brief diet history questionnaire (BDHQ) and the current health questionnaire) before and after dietary intervention. Of the 12 women volunteers with functional constipation, there were six SBM-supplemented subjects who received 3 g of Sujiaonori powder twice daily during meal, whereas the six others (controls) were from the group of those who took 3 g of a power made of 70% corn starch and 30% Japanese spinach mixture. The analysis of data on daily nutrient intake showed no significant dietary changes for nutrients (minerals, proteins, fiber, fat) and calorie intake (except alcohol intake that was reduced) in both groups. In SBM group, a significant reduction of the proportion of women with constipation was observed (p < 0.001), whereas no significant change was noted within the control group (p > 0.05). When both groups were compared, SBM was more effective than the control product; 66.7% (4/6) of SBM-supplemented women had their constipation relieved, whereas only one control (16.7%) controls benefited from dietary intervention (p < 0.001). In addition, no adverse effect was reported in the SBM group, whereas two controls reported nausea at post-survey. These results suggest that Sujiaonori contains compounds that can improve gastrointestinal function and relieve constipation.
Preferred Orientation Contribution to the Anisotropic Normal State Resistivity in Superconducting Melt-Cast Processed Bi2Sr2CaCu2O8+δ
Authors: Dellicour Aline , Vertruyen Benedicte , Rikel Mark , Lutterotti Luca , Pautrat Alain , Ouladdiaf Bachir , Chateigner Daniel
Published: May 2017

We describe how the contribution of crystallographic texture to the anisotropy of the resistivity of polycrystalline samples can be estimated by averaging over crystallographic orientations through a geometric mean approach. The calculation takes into account the orientation distribution refined from neutron diffraction data and literature values for the single crystal resistivity tensor. The example discussed here is a melt-cast processed Bi2Sr2CaCu2O8+δ (Bi-2212) polycrystalline tube in which the main texture component is a <010> fiber texture with relatively low texture strength. Experimentally-measured resistivities along the longitudinal, radial, and tangential directions of the Bi-2212 tube were compared to calculated values and found to be of the same order of magnitude. Calculations for this example and additional simulations for various texture strengths and single crystal resistivity anisotropies confirm that in the case of highly anisotropic phases such as Bi-2212, even low texture strengths have a significant effect on the anisotropy of the resistivity in polycrystalline samples.
Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.
Authors: Kim Kyuri , Leutou Alain S. , Jeong Haein , Kim Dayoung , Seong Chi Nam , Nam Sang-Jip , Lim Kyung-Min
Published: May 2017

Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT–PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, MelanodermTM, and manifested as whitening and regression of melanocyte activation in the tissue.
Preparation and Characterization of Chitosan Obtained from Shells of Shrimp (Litopenaeus vannamei Boone)
Authors: De Queiroz Antonino Rayane , Lia Fook Bianca , De Oliveira Lima Vítor , De Farias Rached Raid , Lima Eunice , Da Silva Lima Rodrigo , Peniche Covas Carlos , Lia Fook Marcus
Published: May 2017

The main source of commercial chitosan is the extensive deacetylation of its parent polymer chitin. It is present in green algae, the cell walls or fungi and in the exoskeleton of crustaceans. A novel procedure for preparing chitosan from shrimp shells was developed. The procedure involves two 10-minutes bleaching steps with ethanol after the usual demineralization and deproteinization processes. Before deacetylation, chitin was immersed in 12.5 M NaOH, cooled down and kept frozen for 24 h. The obtained chitosan was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), UV, X-ray diffraction (XRD) and viscosimetry. Samples of white chitosan with acetylation degrees below 9 % were obtained, as determined by FTIR and UV-first derivative spectroscopy. The change in the morphology of samples was followed by SEM. The ash content of chitosan samples were all below 0.063 % . Chitosan was soluble in 1 % acetic acid with insoluble contents of 0.62 % or less. XRD patterns exhibited the characteristic peaks of chitosan centered at 10 and 20 degrees in 2 θ . The molecular weight of chitosan was between 2.3 and 2.8 × 10 5 g/mol. It is concluded that the procedure developed in the present work allowed obtaining chitosans with physical and chemical properties suitable for pharmaceutical applications.
Grain Refinement Mechanism of the As-Cast and As-Extruded Mg–14Li Alloys with Al or Sn Addition
Authors: Zeng Ying , Jiang Bin , Li Ruihong , Yin Hengmei , Al-Ezzi Salih
Published: May 2017

The microstructures of the as-cast and as-extruded Mg–14 wt. % Li–1 wt. % Al (LA141) and Mg–14 wt. % Li–2 wt. % Sn (LT142) were observed by optical and scanning electron microscope (SEM), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The effects of Al and Sn on the grain refinement on the Mg–14Li alloy were investigated. In addition, the mechanism of grain refinement on the as-cast and as-extruded alloys was discussed from the view of the solute effect and heterogeneous nucleation effect via edge-to-edge matching model. The results showed that the average grain sizes of the as-cast LA141 and LT142 alloys were similar due to the close solute effect of 1.1 wt. % Al and 1.8 wt. % Sn, while, in the as-extruded alloys, the average grain size of LT142 was over two times finer than that of LA141. This was attributed to the reason that Li2MgSn particles can serve as heterogeneous nucleation sites for the β-Li matrix during the process of dynamic recrystallization (DRX), but LiMgAl2 cannot serve the same way. Therefore, Sn can act as a more effective grain refiner for the Mg–14Li alloy compared to Al.
Leaching Process of Rare Earth Elements, Gallium and Niobium in a Coal-Bearing Strata-Hosted Rare Metal Deposit—A Case Study from the Late Permian Tuff in the Zhongliangshan Mine, Chongqing
Authors: Zou Jianhua , Tian Heming , Wang Zhen
Published: May 2017

The tuff, a part of coal-bearing strata, in the Zhongliangshan coal mine, Chongqing, southwestern China, hosts a rare metal deposit enriched in rare earth elements (REE), Ga and Nb. However, the extraction techniques directly related to the recovery of rare metals in coal-bearing strata have been little-studied in the literature. The purpose of this paper is to investigate the extractability of REE, Ga and Nb in the tuff in the Zhongliangshan mine using the alkaline sintering-water immersion-acid leaching (ASWIAL) method. The results show that ASWIAL can separate and extract REE, Ga and Nb effectively under the optimized conditions of calcining at 860 °C for 0.5 h with a sample to sintering agent ratio of 1:1.5, immersing at 90 °C for 2 h with 150 mL hot water dosage, and leaching using 4 mol/L HCl at 40 °C for 2 h with a liquid-solid ratio of 20:1 (mL:g). The final leaching efficiencies of REE and Ga are up to 85.81% and 93.37%, respectively, whereas the leaching efficiency of Nb is less than 1%, suggesting the high concentration of Nb in the leaching residue, which needs further extraction.
Development of Novel Platform to Predict the Mechanical Damage of a Miniature Mobile Haptic Actuator
Authors: Choi Byungjoo , Kwon Jiwoon , Jeon Yongho , Lee Moon
Published: May 2017

Impact characterization of a linear resonant actuator (LRA) is studied experimentally by a newly-developed drop tester, which can control various experimental uncertainties, such as rotational moment, air resistance, secondary impact, and so on. The feasibility of this test apparatus was verified by a comparison with a free fall test. By utilizing a high-speed camera and measuring the vibrational displacement of the spring material, the impact behavior was captured and the damping ratio of the system was defined. Based on the above processes, a finite element model was established and the experimental and analytical results were successfully correlated. Finally, the damage of the system from impact loading can be expected by the developed model and, as a result, this research can improve the impact reliability of the LRA.
An Alternative Source for Ceramics and Glass Raw Materials: Augen-Gneiss
Authors: Kangal Murat , Bulut Gülay , Yeşilyurt Zeynep , Güven Onur , Burat Fırat
Published: May 2017

Due to the depletion of well-known feldspar reserves in the forms of granite, trachyte and pegmatite, many investigations are focused on new and economic alternatives to these resources. Of these, gneiss is a metamorphic rock type, which is characterized by dark and light colored minerals including feldspar and quartz. In this study, Augen-Gneiss rock was subjected to flotation tests to produce alkali (Na + Ca) feldspar and quartz concentrates by adapting different flotation conditions with/without hydrofluoric acid (HF). During these tests, the effect of particle size and different reagent combinations were investigated. The results of these tests showed that, in the presence of HF, a saleable feldspar concentrate with 0.04% Fe2O3 content and a saleable quartz concentrate with 98.45% SiO2 content were obtained. Products with similar qualities to a feldspar concentrate with 0.13% Fe2O3 and a quartz concentrate with 92.53% SiO2 content were produced without HF. The results of these tests clearly showed that, compared to other types of origin, saleable quality feldspar and quartz could well be enriched with/without HF from Augen-Gneiss rock.
Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I)
Authors: Hanna Jill , Allan Christopher , Lawrence Charlotte , Meyer Odile , Wilson Neil , Hulme Alison
Published: May 2017

The CuAAC ‘click’ reaction was used to couple alkyne-functionalized lanthanide-DOTA complexes to a range of fluorescent antennae. Screening of the antenna components was aided by comparison of the luminescent output of the resultant sensors using data normalized to account for reaction conversion as assessed by IR. A maximum 82-fold enhanced signal:background luminescence output was achieved using a Eu(III)-DOTA complex coupled to a coumarin-azide, in a reaction which is specific to the presence of copper(I). This optimized complex provides a new lead design for lanthanide-DOTA complexes which can act as irreversible ‘turn-on’ catalytic sensors for the detection of ligand-bound copper(I).
Evaluation of Efficient and Practical Methods for the Preparation of Functionalized Aliphatic Trifluoromethyl Ethers
Authors: Sokolenko Taras , Dronkina Maya , Magnier Emmanuel , Yagupolskii Lev , Yagupolskii Yurii
Published: May 2017

The “chlorination/fluorination” technique for aliphatic trifluoromethyl ether synthesis was investigated and a range of products with various functional groups was prepared. The results were compared with oxidative desulfurization-fluorination of xanthates with the same structure.