bluuebunny/crossref_metadata_2025 huggingface dataset:
Index-based flood risk assessment for Metro Manila
Authors: Rubio C. J. , Yu I. S. , Kim H. Y. , Jeong S. M.
Published: January 2020

This study focuses on index-based flood risk assessment in Metro Manila, the capital region of the Philippines and most densely populated region in the country. Its objective is to properly address urban characteristics in flood risk assessment by introducing a specific urban-type set of physical, social, economic and ecological indicators. Analytical hierarchy process (AHP) was used to quantify the optimal selection weights for each of the selected 14 indicators. Five levels of flood risk will be presented in spatial maps using geographic information system (GIS) ranging from Very Low Risk to Very High Risk. Results of this study are expected to aid in understanding flood hazard and risk in Metro Manila. Moreover, the resulting flood risk information can be used as a decision tool in policy making, land-use planning, developing guidelines and countermeasures and flood disaster insurance.
Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential
Authors: Su Ma , Wang Weiwei , Liu Feng , Li Huanqiu
Published: January 2020

Background:

Inflammation is the body’s immune system’s fast coordinating response to
irritants caused by pathogens, external injuries, and chemical or radiation effects. The nucleotidebinding
oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome
is a critical component of the innate immune system. The dysfunction of NLRP3 inflammasome
contributes to various pathogeneses of complex diseases, such as uncontrolled infection, autoimmune
diseases, neurodegenerative diseases, and metabolic disorders. This review describes recent
progress on the discovery of NLRP3 inflammasome inhibitors and their therapeutic potential.

Methods:

Based on the mechanism of NLRP3 activation, several types of NLRP3 inhibitors are described
and summarized according to their origins, structures, bioactivity, and mechanism of action.
Structure-Activity Relationship (SAR) is also listed for different scaffolds, as well as effective pharmacophore.

Results:

Over one-hundred papers were included in the review. The development of NLRP3 inhibitors
has been described from the earliest glyburide in 2001 to the latest progress in 2019. Several series of
inhibitors have been categorized, such as JC-series based on glyburide and BC-series based on 2APB.
Many other small molecules such as NLRP3 inhibitors are also listed. SAR, application in related therapeutic
models, and five different action mechanisms are described.

Conclusion:

The findings of this review confirmed the importance of developing NLRP3 inflammasome
inhibitors. Various NLRP3 inhibitors have been discovered as effective therapeutic treatments
for multiple diseases, such as type II diabetes, experimental autoimmune encephalomyelitis, stressrelated
mood disorders, etc. The development of a full range of NLRP3 inflammasome inhibitors is still
at its foundational phase. We are looking forward to the identification of inhibitory agents that provide
the most potent therapeutic strategies and efficiently treat NLRP3 inflammasome-related inflammatory
diseases.
DLEU1: A Functional Long Noncoding RNA in Tumorigenesis
Authors: Song Chaoying , Zhang Jiali , Zhao Zongyao , Yang Yuxia , Meng Di , Wang Jing , Guo Chong , Yuan Chengfu
Published: January 2020

Background:

LncRNA DLEU1 participates in various biological processes, playing an indispensable
role in the pathophysiology of human diseases, especially in tumorigenesis and other processes. Besides, it may
represent a promising target for biotherapy in numerous tumors. The aim of this review was to reveal the pathophysiological
functions and mechanisms of lncRNA DLEU1 in different types of cancer.

Methods:

LncRNA DLEU1 participates in various biological processes, playing an indispensable
role in the pathophysiology of human diseases, especially in tumorigenesis and other processes. Besides, it may
represent a promising target for biotherapy in numerous tumors. The aim of this review was to reveal the pathophysiological
functions and mechanisms of lncRNA DLEU1 in different types of cancer.

Results:

DLEU1 is a novel cancer-associated lncRNA that has been proved to be abnormally elevated in various
malignancies, containing osteosarcoma, glioma, glioblastoma multiforme, hepatocellular carcinoma, bladder
cancer, cervical cancer, non-small cell lung cancer, pancreatic ductal adenocarcinoma, colorectal cancer, oral
squamous cell carcinoma, endometrial cancer, gastric cancer, Burkitt lymphoma and ovarian carcinoma. Besides,
lncRNA LDEU1 has been demonstrated involving in the procession of proliferation, migration, invasion and
inhibition of apoptosis of cancer cells.

Conclusion:

Long non-coding RNA DLEU1 is likely to represent an available biomarker or a potential therapeutic
target in multiple tumors.
Genetics and Epigenetics in the Clinic: Precision Medicine in the Management of Fatty Liver Disease
Authors: Cespiati Annalisa , Youngson Neil A. , Tourna Aikaterini , Valenti Luca
Published: January 2020

This narrative review will discuss the current evidence supporting the possible application of precision
or personalized medicine to the management of nonalcoholic or “metabolic” fatty liver disease (NAFLD), based
on recent progress in the understanding of the genetics and epigenetics of the disease. The prevalence of NAFLD,
which can progress to cirrhosis and hepatocellular carcinoma, is constantly increasing worldwide. Accurate noninvasive
predictors of liver disease progression, as well as of cardiovascular complications of NAFLD, are urgently
needed. Evidence is now reporting that the genetic and epigenetic factors involved in NAFLD development
can be used to develop risk scores for liver-related complications, which may show the possibility to implement
programs for targeted screening and surveillance of complications. Moreover, genetic and epigenetic
factors identifying specific sub-phenotypes of NAFLD can predict the individual response to pharmacological
therapies. Finally, we describe opportunities for gene-targeted therapeutic approaches in NAFLD, where the
genetic variants represent therapeutic targets for precision therapy approaches.
Survey of NMDA Receptor-related Biomarkers for Depression
Authors: Chen Yu-Ming , Lin Chieh-Hsin , Lane Hsien-Yuan
Published: January 2020

Major depressive disorder (MDD) is an important cause of disability in the world. Depression has
negative influences on a person’s mental and physical health, quality of life, and functioning. The pathophysiology
of depression has not yet been confirmed. The traditional monoamine hypothesis of MDD could not explain
the unsatisfactory treatment response of antidepressants. Thus, it is necessary to search other probable pathophysiology
of MDD. In recent years, the role of glutamate neurotransmission in depression has drawn much attention.
The N-methyl-D-aspartate receptor (NMDAR) is a subclass of glutamate receptors and is implicated in
the pathogenesis of MDD and other mental disorders. Furthermore, NMDAR ligands, such as ketamine and Dcycloserine,
have shown antidepressive effects in several studies. The diagnosis of MDD depends on physician’s
subjective evaluation which is often inconsistent. Therefore, reliable objective laboratory biomarkers are essential
for more accurate and consistent diagnosis of MDD. In this review, we firstly described the structure and regulation
of the NMDAR. We then searched different genes involved in the pathway of glutamatergic neurotransmission
and NMDAR, including D-amino acids, glycine, and glutamate. Various related enzymes and transporters
that play a role in the modulation of NMDAR neurotransmission were also surveyed. This review aims to investigate
NMDAR related metabolism, which may serve as feasible indicators for MDD and may contribute to further
exploration of reliable biomarkers for MDD and promote new treatment of depression.
Systematic Understanding of the Mechanisms of Flos Chrysanthemi Indici-mediated Effects on Hypertension via Computational Target Fishing
Authors: Chen Ye-Hui , Lei Shan-Shan , Li Bo , Luo Rong , He Xinglishang , Wang Yu-Zhi , Zhou Fu-Chen , Lv Gui-Yuan , Chen Su-Hong
Published: January 2020

Aim and Objective:

Hypertension-induced stroke and coronary artery disease are significant
causes of global morbidity and mortality. Metabolic hypertension has recently become the leading cause of
hypertension. Flos Chrysanthemi Indici (CIF) has a long history as a treatment of hypertension as part of
traditional Chinese medicine. However, its mechanisms of activity remain largely unknown. This study
was aimed to uncover the potential anti-hypertensive mechanisms of CIF based on network pharmacology.

Materials and Methods:

In this research, a systems pharmacology approach integrating the measurement
of active compounds, target fishing, gene screening, Gene Ontology (GO) pathway analysis, Kyoto
Encyclopedia of Genes and Genomes (KEGG) Orthology Based Annotation System (KOBAS) database
analysis, and compound-target network construction were performed to explore the anti-hypertensive
mechanisms of CIF.

Results:

These studies revealed that 12 bioactive compounds in CIF had good druggability, 5 of which
were flavonoids. After screening, 8 of those 12 bioactive compounds interacted with 118 hypertensionrelated
target genes, which were mapped to 218 signal pathways. Network analysis showed that these
targets were associated with improving insulin resistance, improving vascular function, inhibiting renninangiotensin-
aldosterone system (RAAS), inhibiting the sympathetic nervous system (SNS) and regulating
other physiological processes.

Conclusion:

In summary, CIF is predicted to target multiple proteins and pathways to form a network that
exerts systematic pharmacological effects in order to regulate blood pressure and metabolic disorder.
Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis
Authors: Damrongrungruang Teerasak , Panpitakkul Panjaree , Somudorn Jirachaya , Sangchart Pimpitchaya , Mahakunakorn Pramote , Uthaiwat Prangtip , Daduang Jureerut , Panyatip Panyada , Puthongking Ploenthip , Priprem Aroonsri
Published: January 2020

Background:

Glutaryl melatonin, which is synthesized from melatonin and is a pineal glandderived neurohormone with anti-inflammatory and anti-oxidant properties, was comparatively investigated for its potential use as a topical anti-inflammatory agent.

Objective:

Glutaryl melatonin, synthesized and screened for in vitro anti-candidiasis and in vitro and in vivo anti-inflammatory activities, was formulated as a niosome gel for topical oral evaluation in 5- fluorouracil-induced oral mucositis in mice.

Methods:

In vitro anti-fungal activity in Candida albicans, in vitro anti-inflammatory activity in Escherichia coli liposaccharide-induced RAW cells and in vivo anti-inflammatory activity using a croton oilinduced ear edema model in ICR mice were investigated. Mucositis in mice (n= 6/group, 10-week-old mice) was induced by intraperitoneal injections of 5-fluorouracil, and the mice were subjected to a topical oral application of niosome gel containing melatonin (2% w/w) or glutaryl melatonin (2% w/w) and were compared with mice subjected to blank, fluocinolone acetonide (0.5% w/w) and control conditions.

Results:

Glutaryl melatonin, at a 14.2 mM concentration, showed the highest fungicidal effect on C. albicans using the broth dilution method, indicating a nonsignificant difference from 1 μM of nystatin (p = 0.05). Nitric oxide, interleukin-6 and tumor necrosis factors were analyzed by ELISA. Liposaccharide-induced RAW cells were significantly reduced by glutaryl melatonin (p < 0.01). Ear edema inhibition of glutaryl melatonin was significant 1 h after application compared with that of melatonin (p = 0.03). Food consumption and body weight of the 5-fluorouracil-treated mice were significantly lower than those of the normal mice before all treatments (p < 0.05). Differences in the amount of licking behavior, which were observed in the control group for 5 min, were noticeable in the 5- fluorouracil-treated mice but not in the mice treated with the glutaryl melatonin niosome gel.

Conclusion:

Glutaryl melatonin exhibited mild anti-candidiasis and anti-inflammatory properties. The incorporation of glutaryl melatonin in a niosome gel formulation, demonstrated the potential for topical oral applications to reduce oral discomfort caused by 5-fluorouracil treatment in mice.
Delivery Efficacy Differences of Intravenous and Intraperitoneal Injection of Exosomes: Perspectives from Tracking Dye Labeled and MiRNA Encapsulated Exosomes
Authors: Zhou Xueying , Li Zhelong , Sun Wenqi , Yang Guodong , Xing Changyang , Yuan Lijun
Published: January 2020

Background:

Exosomes are cell-derived nanovesicles that play vital roles in intercellular
communication. Recently, exosomes are recognized as promising drug delivery vehicles. Up till now,
how the in vivo distribution of exosomes is affected by different administration routes has not been fully
understood.

Methods:

In the present study, in vivo distribution of exosomes following intravenous and intraperitoneal
injection approaches was systemically analyzed by tracking the fluorescence-labeled exosomes and
qPCR analysis of C. elegans specific miRNA abundance delivered by exosomes in different organs.

Results:

The results showed that exosomes administered through tail vein were mostly taken up by the
liver, spleen and lungs while exosomes injected intraperitoneally were more dispersedly distributed.
Besides the liver, spleen, and lungs, intraperitoneal injection effectively delivered exosomes into the
visceral adipose tissue, making it a promising strategy for obesity therapy. Moreover, the results from
fluorescence tracking and qPCR were slightly different, which could be explained by systemic errors.

Conclusion:

Together, our study reveals that different administration routes cause a significant differential
in vivo distribution of exosomes, suggesting that optimization of the delivery route is prerequisite
to obtain rational delivery efficiency in detailed organs.
Role of Oxidative Stress and Metal Toxicity in the Progression of Alzheimer’s Disease
Authors: Birla Hareram , Minocha Tarun , Kumar Gaurav , Misra Anamika , Singh Sandeep Kumar
Published: January 2020

Alzheimer’s disease (AD) is one of the life-threatening neurodegenerative disorders in the elderly (>60 years) and incurable across the globe to date. AD is caused by the involvement of various genetic, environmental and lifestyle factors that affect neuronal cells to degenerate over the period of time. The oxidative stress is engaged in the pathogenesis of various disorders and its key role is also linked to the etiology of AD. AD is attributed by neuronal loss, abnormal accumulation of Amyloid-β (Aβ) and neurofibrillary tangles (NFTs) with severe memory impairments and other cognitive dysfunctions which lead to the loss of synapses and neuronal death and eventual demise of the individual. Increased production of reactive oxygen species (ROS), loss of mitochondrial function, altered metal homeostasis, aberrant accumulation of senile plaque and mitigated antioxidant defense mechanism all are indulged in the progression of AD. In spite of recent advances in biomedical research, the underlying mechanism of disruption of redox balance and the actual source of oxidative stress is still obscure. This review highlights the generation of ROS through different mechanisms, the role of some important metals in the progression of AD and free radical scavenging by endogenous molecule and supplementation of nutrients in AD.
Review of Phytochemical Compounds as Antiviral Agents Against Arboviruses from the Genera Flavivirus and Alphavirus
Authors: Sardari Samira , Rafieian-Kopaei Mahmoud , Malekmohammad Khojasteh , Sewell Robert D.E.
Published: January 2020

Arboviruses are a diverse group of viruses that are among the major causes of emerging
infectious diseases. Arboviruses from the genera flavivirus and alphavirus are the most important
human arboviruses from a public health perspective. During recent decades, these viruses have
been responsible for millions of infections and deaths around the world. Over the past few years,
several investigations have been carried out to identify antiviral agents to treat these arbovirus infections.
The use of synthetic antiviral compounds is often unsatisfactory since they may raise the
risk of viral mutation; they are costly and possess either side effects or toxicity. One attractive
strategy is the use of plants as promising sources of novel antiviral compounds that present significant
inhibitory effects on these viruses. In this review, we describe advances in the exploitation of
compounds and extracts from natural sources that target the vital proteins and enzymes involved in
arbovirus replication.
Chromene, Quinoline Hybrids as Potential Anti-Cancer Agents: A Novel and Distinct Approach for the Synthesis of Quinoline Derivatives
Authors: Sultana Rizuana , Tippanna Ravinder Reddy
Published: January 2020

A series of novel quinoline derivatives (6-phenyl-6H-chromeno[4,3-b]quinoline) have been prepared by using 4-chloro-2-phenyl-2H-chromene-3-carbaldehyde and various substituted isocyanides as starting materials in the presence of HClO4-SiO2 and Methanol. We screened eighteen compounds of this novel series (6a-r) in six different cancer cell lines (A549 (lung cancer cells), DU145 (prostate cancer cells), PC3 (prostate cancer cells), MCF7 (lung cancer cells), HT 29, HCT 116 (colon cancer cells). Most of the compounds showed anti-cancer activity and compound 6b showed good cytotoxicity IC50 = 2.61±0.34 μM against colon cancer on HT29 cell line among all. The key property of cell migration was observed while treatment cells with 6b. Apoptosis in HT29 cells confirmed by annexin V staining, acridine orange/ethidium bromide (AO/EB), DAPI, induced by 6b. This method is operationally simple and works with a diverse range of substrates. These results indicate the anticancer potential of these series and warrants future investigations for further anticancer drug development.
Microencapsulation of Probiotics by Exopolysaccharides-sodium Alginate and Evaluation of their Survival in Simulated GI Conditions
Authors: Singh Priyanka , Saini Pinki , Dubey Shreyasi , Srivastava Urvashi , Singh Anchal , Kaur Devinder , Choudhary Raveena
Published: January 2020

Background:

The viability of the probiotics reduces because of the high acid and bile salt
concentrations present in the stomach. Probiotic cultures can be protected during processing, storage
and passage of the probiotic product through the gastrointestinal tract by the technique of microencapsulation.

Objective:

In the present study, Exopolysaccharides (EPS) and sodium alginate are incorporated in a
different ratio to form the encapsulation matrix. They have also been checked for improving the viability
of lactic acid bacteria in simulated GI conditions.

Methods:

EPS were isolated from a reference strain of L. acidophillus and the two strains P8 and
Cu3 isolated from pumpkin and cucumber. Microencapsulated beads were formed using a different
combination of EPS and sodium alginate and were analysed in terms of viability, bile tolerance, acid
tolerance, survival in gastrointestinal conditions, and antibiotic susceptibility conditions.

Results:

The results indicated that the increasing concentration of EPS has significantly increased the
survival of microencapsulated probiotic in simulated gastrointestinal conditions. The treatment T4
was found to be the best for all the tested conditions.

Conclusion:

This study has shown the potential application of EPS in microencapsulation to protect
probiotics against the adverse condition of the gastrointestinal tract.
The Effect of Olive Oil and Honey Combination on Episiotomy Wound Healing and Pain Relief: A Randomized Clinical Trial
Authors: Shayan Arezoo , Sourinezhad Hadis , Barzegar Fariba , Ahmadinia Hassan , Masoumi Zahra , Moradkhani Shirin , Refaei Mansoureh
Published: January 2020

Background:

Episiotomy is one of the most common surgical procedures in the world that is associated with perineal pain and can be exposed to infection, or might be healed with delay.

Objective:

The aim of this study was to investigate the effects of honey-olive oil combination on episiotomy wound healing and pain relief in primiparous women.

Methods:

This single-blind, parallel randomized clinical trial (IRCT20120215009014N208) was conducted on 80 primiparous women. They were allocated randomly to each of the groups through random allocation rule: 40 in honey-olive oil group and 40 in the control group. Every 12 hours and for 14 days, the treatment group used about 1 inch of the cream on the wound area. Pain intensity and wound healing were measured by REEDA Scale and Visual Analogue Scale on days 7, 10, and 14 in both groups. The statistical analyst was not informed about the allocation of the groups. A significant level of 0.05 was considered.

Results:

There was a significant difference between healing score and pain intensity between the two groups on 7th, 10th and 14th postpartum days (p <0.05). Wound healing occurred much faster (Scores on days 7,10, and 14 were 11.25±2.13, 7.47±1.96 and 4.95±1.53 in the control group and 4.45±1.25, 2.32±.69 and 10±.30 in the intervention group, p <0.05). Moreover, pain intensity was significantly relieved in those who used Honey and olive oil cream (the scores were 5.6750±1.43, 3.3500±1.52, 2.2250±1.34 in the control group and 1.9750±1.52, .2250±.57, .0250±.15 in the intervention group, p<0.05).

Conclusion:

Using honey and olive oil combination improves episiotomy wound healing and also relieves its’ associated pain.
The Noncoding Side of Cardiac Differentiation and Regeneration
Authors: Pagano Francesca , Calicchio Alessandro , Picchio Vittorio , Ballarino Monica
Published: January 2020

Large scale projects such as FANTOM and ENCODE led to a revolution in our comprehension
of the mammalian transcriptomes by revealing that ~53% of the produced RNAs do not encode
for proteins. These transcripts, defined as noncoding RNAs (ncRNAs), constitute a heterogeneous
group of molecules which can be categorized in two main classes, namely small and long, according to
their length. In animals, the first-class includes Piwi-interacting RNAs (piRNAs), small interfering
RNAs (siRNAs) and microRNAs (miRNAs). Among them, the best-characterized subgroup is represented
by miRNAs, which are known to regulate gene expression largely at the post-transcriptional
level. In contrast, long noncoding RNAs (lncRNAs) represent a more heterogeneous group of > 200
nucleotides long transcripts, that act through a variety of mechanisms at both transcriptional and posttranscriptional
level.

Here, we discuss how miRNAs and lncRNAs are emerging as pivotal regulators of cardiac muscle
development and how the alteration of ncRNA expression was seen to disturb the physiology of all the
different cell types forming the cardiac tissue. Particular emphasis is given to those species that are
expressed and are known to regulate the capacity of cardiac progenitor cells (CPCs), currently used in
regenerative medicine protocols, to proliferate and differentiate. Understanding how the ncRNAmediated
circuitries regulate heart homeostasis is one of the research areas expected to have a high
impact, improving the therapeutic efficacy of stem/progenitor-cells treatments for translation into
clinical applications.
The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders
Authors: Bhattacharjee Chiranjib , Deb Lokesh
Published: January 2020

In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm,
endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary
and essential for cell viability, signal transduction, cell-cycle control as well as
transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a
vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious
inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently
a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious
diseases. Based on the biology of HSP-90, several COOH-terminal ATPase sites of
HSP-90, NH2-terminal ATPase sites of HSP-90, and Histone deacetylase inhibitors are
evaluated and classified under various groups. For the treatment of different inflammatory
disorders, HSP-90 identified as a promising therapeutic target. The present review may guide
researchers for evaluating the HSP-90 targeted pathway as a useful therapeutic target for inflammatory
diseases, including cancers.
Manganese Ore-based Wet Flue-Gas Desulfurization: A Review
Authors: Liu Yutong , Jiang Wenju , Yao Lu , Yang Lin , Jiang Xia
Published: January 2020

The removal of SO2 from flue gases is necessary for eliminating haze and controlling
acid rain. However, developing the traditional wet and dry flue-gas desulfurization
(FGD) is challenging due to the disposal issue of several byproducts. Manganese (Mn) orebased
wet FGD possesses many advantages, including good desulfurization property, low
cost, and high economic benefit. The environment friendliness and reusability of MnSO4
provide new ideas and methods in the future research direction of FGD. This review summarizes
the background information of Mn ore slurry desulfurization, the desulfurization mechanism,
the technological process, and the desulfurization devices. The role of operating parameters,
such as temperature, liquid/solid ratio, pH, SO2 concentration, and particle size, in
the desulfurization efficiency and manganese leaching rate are also discussed. The temperature
(20°C-80°C) has exerted little effect on the desulfurization efficiency, whereas a low pH
value is beneficial for SO2 removal. Moreover, a low inlet SO2 concentration and small particle
size are beneficial for SO2 removal. The control and digestion techniques related to the
byproduct (manganese dithionate) are also presented, along with the future development direction
of Mn ore-based wet FGD in different industries.
Censo aéreo invernal de aves playeras en la costa de Sonora, México (invierno 2016-2017)
Authors: Carmona Roberto , Águila Sergio Noé , Vidal Sharin , Carmona-Islas Cynthia , Danemann Gustavo
Published: January 2020

Evaluamos la importancia numérica de las lagunas costeras sonorenses para la invernada de aves playeras, a través de recorridos aéreos en las 13 lagunas de mayor tamaño durante febrero de 2017. Realizamos en total 400,716 registros, el 70% de éstos se llevaron a cabo en la porción sur, el 9% en el centro y el 21% al norte del estado. Las tres bahías con mayores números y porcentajes de aves playeras fueron Tóbari (127,570 registros, 32%), Yavaros-Moroncarit (86,469 registros, 21%) y Lobos (55,684 registros, 14%). Otros sitios con abundancias absolutas y relativas importantes fueron: Bahía San Jorge (34,768 registros, 9%), Santa Clara (18,769 registros, 5%) y el Delta del Río Colorado (20,184 registros, 5%). Por talla de los individuos, las abundancias de aves pequeñas (15-22 cm) y grandes (más de 36 cm) fueron similares (48% y 43%, respectivamente), las aves de talla media (24-30 cm) fueron menos comunes (8%). Los números encontrados permiten ubicar a Sonora entre los tres estados de la república con mayor abundancia de aves playeras invernantes (junto con Baja California Sur y Sinaloa).
An Integrative Model for the Effectiveness of Biofeedback Interventions for Anxiety Regulation: Viewpoint
Authors: Weerdmeester Joanneke , van Rooij Marieke MJW , Engels Rutger CME , Granic Isabela
Published: January 2020

Biofeedback has shown to be a promising tool for the treatment of anxiety; however, several theoretical as well as practical limitations have prevented widespread adaptation until now. With current technological advances and the increasing interest in the use of self-monitoring technology to improve mental health, we argue that this is an ideal time to launch a new wave of biofeedback training. In this viewpoint paper, we reflect on the current state of biofeedback training, including the more traditional techniques and mechanisms that have been thought to explain the effectiveness of biofeedback such as the integration of operant learning and meditation techniques, and the changes in interoceptive awareness and physiology. Subsequently, we propose an integrative model that includes a set of cognitive appraisals as potential determinants of adaptive trajectories within biofeedback training such as growth mindset, self-efficacy, locus of control, and threat-challenge appraisals. Finally, we present a set of detailed guidelines based on the integration of our model with the mechanics and mechanisms offered by emerging interactive technology to encourage a new phase of research and implementation using biofeedback. There is a great deal of promise for future biofeedback interventions that harness the power of wearables and video games, and that adopt a user-centered approach to help people regulate their anxiety in a way that feels engaging, personal, and meaningful.
Reproducibility of Deceased Donor Kidney Procurement Biopsies
Authors: Husain S. Ali , King Kristen L. , Batal Ibrahim , Dube Geoffrey K. , Hall Isaac E. , Brennan Corey , Stokes M. Barry , Crew R. John , Carpenter Dustin , Alvarado Verduzco Hector , Rosen Raphael , Coley Shana , Campenot Eric , Santoriello Dominick , Perotte Adler , Natarajan Karthik , D’Agati Vivette D. , Cohen David J. , Ratner Lloyd E. , Markowitz Glen , Mohan Sumit
Published: January 2020

Background and objectives

Unfavorable histology on procurement biopsies is the most common reason for deceased donor kidney discard. We sought to assess the reproducibility of procurement biopsy findings.

Design, setting, participants, & measurements

We compiled a continuous cohort of deceased donor kidneys transplanted at our institution from 1/1/2006 to 12/31/2016 that had at least one procurement biopsy performed, and excluded cases with missing biopsy reports and those used in multiorgan transplants. Suboptimal histology was defined as the presence of advanced sclerosis in greater than or equal to one biopsy compartment (glomeruli, tubules/interstitium, vessels). We calculated κ coefficients to assess agreement in optimal versus suboptimal classification between sequential biopsy reports for kidneys that underwent multiple procurement biopsies and used time-to-event analysis to evaluate the association between first versus second biopsies and patient and allograft survival.

Results

Of the 1011 kidneys included in our cohort, 606 (60%) had multiple procurement biopsies; 98% had first biopsy performed at another organ procurement organization and their second biopsy performed locally. Categorical agreement was highest for vascular disease (κ=0.17) followed by interstitial fibrosis and tubular atrophy (κ=0.12) and glomerulosclerosis (κ=0.12). Overall histologic agreement (optimal versus suboptimal) was κ=0.15. First biopsy histology had no association with allograft survival in unadjusted or adjusted analyses. However, second biopsy optimal histology was associated with a higher probability of death-censored allograft survival, even after adjusting for donor and recipient factors (adjusted hazard ratio, 0.50; 95% confidence interval, 0.34 to 0.75; P=0.001).

Conclusions

Deceased donor kidneys that underwent multiple procurement biopsies often displayed substantial differences in histologic categorization in sequential biopsies, and there was no association between first biopsy findings and post-transplant outcomes.
La regulación de la maternidad subrogada en los estados de Tabasco y Sinaloa. Comparativa con la prohibición de maternidad por sustitución del derecho español
Authors: Álvarez de Toledo Quintana Lorenzo
Published: January 2020

El presente trabajo tiene por objeto analizar de forma sucinta y sin ningún propósito agotador, el estado de la cuestión de la maternidad subrogada en dos modelos jurídicos de signos opuestos: el modelo español, en el que rige la prohibición de la maternidad subrogada; y los de dos Estados mexicanos, Tabasco y Sinaloa, donde se regula el proceso procreativo con determinadas garantías para la parte más débil de la relación jurídica, la madre gestante.

Es mi propósito defender la necesidad de una urgente regulación en España que dé una respuesta completa, actualizada y respetuosa con la dignidad y derechos fundamental de todas las partes: primordialmente, del niño por nacer, que, a diferencia de lo que ocurre en la adopción (se busca una familia para el niño) supone la búsqueda de un hijo para una familia.

El examen del derecho comparado ofrece una herramienta insustituible en la búsqueda del Derecho justo y el examen -necesariamente breve-  de los modelos jurídicos de tabasco y de Sinaloa, representa un avance hacia el debate que queremos y necesitamos en España.
Kelsen e o positivismo jurídico contemporâneo: notas de um (possível) acerto de contas
Authors: Streck Lenio Luiz
Published: January 2020

O   Positivismo  Jurídico  é um   paradigma  complexo. Compreendê-lo em suas  diversas versões e, sobretudo, por inter- médio dos  standards de racionalidade que o sustenta ao  longo de sua história é um  dos  desafios da teoria do Direito de perfil hermenêutico. Neste ensaio crítico busca-se confrontar o Juspositivismo contemporâneo a partir de um  dos  principais teóricos desta mesma corrente de pensamento: Hans  Kelsen. O  texto se inicia  com duas breves seções. Uma  acerca da  genealogia do Positivismo e a outra sobre o modo como Kelsen conseguiu desenvolver uma Ciência do Direito. Após, a discussão se volta para  as seguintes falhas  do positivismo jurídico hodierno: 1) a ausência de uma metalinguagem; 2) a ausência de uma preocupação com a diferença entre causalidade e imputação; 3) o paradoxo ou autocontradição exclusivista.
Feminicidio en el sistema penal brasileño
Authors: Brandão Augusto Cristiane
Published: January 2020

Con un feminicidio a cada noventa minutos, Brasil es hoy el quinto país del mundo con las mayores tasas de muertes violentas de mujeres. Como un fenómeno de la estructura patriarcal de la sociedad, el feminicidio se expresa por la misoginia, por la opresión, por la dominación masculina, siendo la forma fatal entre las violencias de género. En ese sentido, este artículo pretende mapear sus concepciones, analizar la concreción legislativa brasileña con su tipificación, así como su recepción por el sistema jurídico y el modo por el cual se vienen asimilando (o no) los principios básicos de la promoción de igualdad en el Estado Democrático de Derecho, con la necesaria superación de la discriminación y de los estereotipos de género en el Poder Judicial. Aquí, el método empírico, base de la investigación de campo en los Tribunales del Jurado de Río de Janeiro, nos ayuda a dimensionar la realidad de instituciones sexistas poco comprometidas con la consolidación de una ciudadanía femenina plena y con los Derechos Humanos de las Mujeres.
PENGARUH PEMBELAJARAN RECIPROCAL TEACHING TERHADAP HASIL BELAJAR BIOLOGI SISWA KELAS VII SMPN PAYAKUMBUH
Authors: Nengsi Sri
Published: January 2020

Penelitian ini dilatar belakangi oleh rendahnya hasil belajar Biologi siswa kelas VII SMPN 9 Payakumbuh. Penelitian ini bertujuan untuk mengetahui pengaruh penerapan  pembelajaran aktif pendekatan Reciprocal teaching terhadap hasil belajar Biologi siswa kelas VII SMPN 9 Payakumbuh. Penelitian ini merupakan penelitian eksperimen dengan rancangan penelitian Randomized control-group posttest only design. Berdasarkan skor terakhir hasil belajar Biologi siswa, diperoleh rata-rata kelas eksperimen 76,89 dengan simpangan baku 7,7939 dan kelas kontrol 66,77 dengan simpangan baku 11,8487. Berdasarkan hasil  analisis data maka diperoleh t'=3,67> 2,05 talpha, sehingga H0 ditolak dan H1 diterima. Dengan demikian dapat disimpulkan bahwa terdapat pengaruh penerapan pembelajaran aktif pendekatan Reciprocal teaching terhadap hasil belajar Biologi siswa kelas VII SMPN 9 Payakumbuh.
Implementation of Internet of Things depends on intention: young farmers’ willingness to accept innovative technology
Authors: Chuang Jui-Hsiung , Wang Jiun-Hao , Liang Chaoyun
Published: January 2020

Innovative applications of smart technology constitute a current trend in agricultural development. This study employed a technology acceptance model to explore the intention of young farmers to apply Internet of Things systems in field-level management of Taiwanese farms. An online questionnaire was used to collect data regarding farmers aged 45 years or younger who were currently engaged in agricultural production. Statistical analysis of 241 valid questionnaires revealed that young farmers’ intention to use innovative technologies was affected mainly by perceived organizational support, followed by average annual turnover, perceived usefulness, perceived ease of use, and sense of trust in the system supplier. This study suggests that agricultural administration agencies should consider farmers’ farming needs and intention to use; agencies should employ problem-solving and design thinking when developing smart agriculture policies. Insightful design of incentives and guidance measures enables young farmers to maximize achievement and to minimize effort.
Da possibilidade de concessão de tutela provisória de urgência por juízo absolutamente incompetente
Authors: Schneider Camila , Rodrigues Marco Antônio
Published: January 2020

RESUMOO estudo tem o desígnio de analisar a possibilidade de concessão de tutela provisória de urgência por juízo absolutamente incompetente, partindo-se da interpretação sistemática do novo modelo de processo instaurado pelo Código de Processo Civil de 2015. Para tanto, explanam-se, inicialmente, as principais alterações relacionadas às normas de fixação de competência. Após, em breve síntese, discorre-se sobre o instituto da tutela provisória de urgência, seus requisitos e principais características. Na sequência, abordam-se os fundamentos que ensejariam, de forma excepcional, a concessão da tutela por juízo absolutamente incompetente. Destaca-se, ante sua natureza procedimental, a possibilidade de flexibilização das normas de fixação de competência e que o debate, em que pese oriundo de tais normas, relaciona-se à colisão de princípios constitucionais e fundamentais processuais, devendo ser dada prevalência, ante a finalidade última da relação processual, à prestação da tutela jurisdicional adequada, efetiva e tempestiva, a qual foi elevada, pelo legislador infraconstitucional, a compromisso fundamental, consagrando-se, pois, o princípio do processo justo.PALAVRAS-CHAVEDireito processual civil. Tutela provisória de urgência. Juízo Absolutamente incompetente. Processo justo. Princípios. Ponderação. ABSTRACTThe study has the purpose of analyzing the possibility of granting provisional remedy of urgency by an absolutely incompetent court, starting with the systematic interpretation of the new model of process established by the Code of Civil Procedure of 2015. For this, at first, the main changes related to the rules for determining jurisdiction are explained. After, in a brief summary, the institute of provisional protection of urgency, its requirements and main characteristics are described. Subsequently, the grounds for granting protection by a totally incompetent court are examined. It is noted that, given its procedural nature, the possibility of flexibilization of the norms of determination of competence and that the debate, however derived from such norms, is related to constitutional and fundamental procedural principles, and the ultimate purpose of the procedural relationship should be given to the provision of adequate, effective and timely judicial protection, which has been elevated by the infraconstitutional legislator to a fundamental commitment, consecrating the principle of a fair process.KEYWORDSCivil procedure. Provisional remedy of urgency. Absolutely incompetent court. Fair process. Principles. Weighting.
A competência municipal para legislar sobre Direito Minerário e a possibilidade de proibição do exercício da atividade extrativa mineral
Authors: Mendes Gabriela Ariane Ribeiro , Costa Beatriz Souza
Published: January 2020

RESUMOO artigo discorre acerca das competências legislativas ambientas com vistas a verificar se o ente municipal estaria ou não dotado de competência legislativa para estabelecer normas afetas ao Direito Minerário, podendo, assim, proibir a prática da referida atividade no âmbito de seu território. Para tanto, analisa não só a evolução do Federalismo brasileiro, como também a importância adquirida por aquele ente na sistemática adotada pela Constituição de 1988. A partir disso, estuda-se como tal relevância impacta diretamente na forma de interpretação do complexo modelo de repartição de competência instituído pelo constituinte pátrio. Por fim, examina-se a transversalidade exercida pelo Direito Ambiental no campo do Direito Minerário, de forma a se examinar a possibilidade ou não de, dentro dos limites de sua competência, o Município legislar a respeito desse último. Com fins de atingir a tais objetivos, utilizou-se da metodologia jurídico-teórica, bem como raciocínio dedutivo e pesquisa doutrinária e jurisprudencial. Ao final, concluiu-se que em razão da interferência direta promovida pelo Direito Ambiental no Direito Minerário, o ente municipal encontra-se incumbido de competência legislativa para estabelecer normas que afetem diretamente o exercício da atividade extrativa mineral, sem, entretanto, inviabilizá-la abstratamente.PALAVRAS-CHAVEFederalismo. Competência legislativa municipal. Direito Minerário. Direito Ambiental. ABSTRACTThis article discusses if Brazilian Constitution gave the local sphere of government competence to establish laws regarding mining law, to the point that the practice of mining activities could be completely forbidden by that instance of power. In order to achieve the answer to said problem, it analyses not only the evolution of Federalism in Brazil, but also the importance that the constituent gave to the local sphere of government in the 1988 Constitution. In sequence, it elucidates how that importance directly affects the form chosen by the constituent to allocate legislative competences amongst the different instances of power. Lastly, it examines the existing connection between Mining and Environmental Law, in a way that it could affect the capability of the local instance of power to create laws regarding the exploration of mining resources. So as to find the answer to said problem, it was used the legal and theoretical methodology, deductive reasoning and the research through literature and jurisprudence regarding the theme. Throughout this paper, it was concluded that considering the direct interference promoted by Environmental Law in the Mining Law sphere, the local instance was given the power to establish laws regarding mining activities, as long as it doesn’t turn it abstractly unfeasible. KEYWORDSFederalism. Local competence. Mining Law. Environmental Law.
A (r)evolução do conceito de soberania estatal e a efetividade do princípio da dignidade da pessoa humana
Authors: Ribeiro Daniela Menengoti , Flores Simone Fogliatto
Published: January 2020

RESUMOO presente artigo investiga a (r)evolução do conceito de soberania estatal em face da supremacia do princípio da dignidade da pessoa humana nas relações internacionais. Enfoca a relativização que a soberania dos Estados Nacionais vem sofrendo ante o caráter prioritário atualmente conferido ao princípio da dignidade da pessoa nas relações internacionais. A mundialização da justiça exige uma reestruturação da sociedade internacional que, na luta pela preservação dos direitos humanos, põe em xeque a manutenção da rigidez do Direito que os Estados possuem de se autodeterminar e de não sofrer intervenção de outros Estados ou organizações internacionais. O atual cenário internacional, com prioridade na defesa dos direitos humanos, não mais admite violações ao princípio da dignidade da pessoa, assistidas passivamente pela sociedade internacional. A origem e a (r)evolução histórica do conceito de soberania, assim como o fortalecimento do princípio da dignidade humana instigam a presente pesquisa. Assim, diante deste cenário mundial, exsurge o problema a ser debatido no artigo. O trabalho adota o método de abordagem dedutivo, e as pesquisas bibliográfica e documental como método de procedimento.PALAVRAS-CHAVEDireitos Humanos. Soberania. Dignidade Humana. Efetividade. ABSTRACTThis article investigates the (r)evolution of the concept of state sovereignty in the face of the supremacy of the principle of the dignity of the human in international relations. It focuses on the relativization that the sovereignty of the National States has suffered in the face of the priority given to the principle of the dignity of the human person in international relations. The globalization of justice requires a restructuring of the international society which, in the struggle for the preservation of human rights, puts in check the maintenance of the rigidity of the law that the states have of self-determination and of not being subject to intervention of other States or international organizations. The current international scenario, with priority in the defense of human rights, no longer admits violations of the principle of the dignity of the human being, passively assisted by international society. The origin and historical (r)evolution of the concept of sovereignty, as well as the fortification of the principle of human dignity instigate the present research. Thus, in light of this world scenario, the problem to be debated in the article excludes. The work adopts the method of deductive approach, and bibliographical and documentary research as method of procedure.KEYWORDSHuman Rights. Sovereignty. Human Dignity. Effectiveness.
A PRODUÇÃO CIENTÍFICA RESULTANTE DE TESES E DISSERTAÇÕES EM PROGRAMAS DE PÓS-GRADUAÇÃO EM EDUCAÇÃO FÍSICA NO PERÍODO DE 2013 A 2017
Authors: Frasson Jéssica Serafim , Molina Neto Vicente , Wittizorecki Elisandro Schultz
Published: January 2020

Este estudo objetiva apresentar uma configuração da produção científica resultante de teses e dissertações da Educação Física (EF) brasileira nos programas de pós-graduação (PPG) da Área 21 entre os anos 2013/2017. Para tal, foi realizada uma busca no Catálogo de Teses e Dissertações da Capes, na Plataforma Sucupira e uma análise do Relatório de Avaliação Quadrienal da Área 21. Foram identificadas 2.969 produções, sendo 2.371 dissertações de mestrado e 598 teses de doutorado. Olhando para as produções, foi possível destacar a pluralidade e a polissemia do conhecimento na Área. Identificou-se, porém, também uma hegemonia que demonstra uma certa visão sobre uma forma específica de produzir/construir conhecimento, que é regido por aqueles  que dominam o campo da EF com um maior capital científico, a subárea biodinâmica.
AS EXPERIÊNCIAS DE LAZER NA CIDADE: O COTIDIANO DA PRAÇA DE BOLSO DO CICLISTA DE CURITIBA, PARANÁ
Authors: Santana Daniella Tschöke , Rechia Simone , Rodrigues Emília Amélia Pinto Costa , Moro Luize
Published: January 2020

Microrrevolução coletiva e marco da cultura da bicicleta em Curitiba/PR, a Praça de Bolso do Ciclista (PBC) é um pequeno espaço público cujo processo de implementação revelou questões significativas para a vida na cidade. Objetivou-se descrever as formas de apropriação da PBC, com o olhar voltado para o cotidiano vivido após sua inauguração, tendo como base as experiências de lazer. Estudo de caso de abordagem qualitativa, utilizou-se de documentos, observações sistemáticas, registros fotográficos e entrevistas semiestruturadas como fontes de evidências. Percebeu-se que as formas de apropriação foram sendo modificadas após a inauguração da praça, espaço que abriga diversos usos e que, mesmo com todas as controvérsias decorrentes de uma apropriação rápida e intensa do local, tornou-se também um espaço de ação política e cidadã, pelo “ativismo gentil” (COOMBS, 2012) que promove, acomodando novas e diversas relações sociais, mas também ressaltando outras já existentes, a partir de atividades vivenciadas no lazer.