bluuebunny/crossref_metadata_2025 huggingface dataset:
Finite Element Analysis (FEA) for a Different Type of Cono-in Dental Implant
Authors: Callea Caterina , Ceddia Mario , Piattelli Adriano , Specchiulli Alessandro , Trentadue Bartolomeo
Published: April 2023

The aim of biomechanics applied to implantology is to determine the deformative and tensional states by solving the equilibrium equations within the mandibular bone and the osseointegrated implant to ensure its stability and improve the success rate. The finite element method is a powerful numerical technique that uses computing power to derive approximate solutions for the analysis of components with very complex geometry, loads, materials, and especially the biomechanical problems analysis, which is challenging to find in vivo or in vitro. This study performs a complete FEA survey on 3 implants Cono-in with 3 different diameters 3.4 mm, 4.5 mm, and 5.2 mm with abutments inclined to 15° and evaluates the tensions that are generated in the system as a result of the application of chewing loads. In this study, the extent of the stresses developed in the peri-crestal zone of the implants with the variation of the occlusal overstress acting on them was also evaluated. Autodesk Inventor Nastran Software was used to perform this type of localized finite element analysis; With this type of analysis, it was possible to analyze the peri-crestal area of the implant more precisely through a more accurate reconstruction of the mesh element, which allowed us to solve the FEA solution mathematically. The results showed how the application of the inclined load with respect to the vertical load on a larger diameter system leads to an increase in stress.
Two-Stage PNN–SVM Ensemble for Higher Education Admission Prediction
Authors: Zub Khrystyna , Zhezhnych Pavlo , Strauss Christine
Published: April 2023

In this paper, we investigate the methods used to evaluate the admission chances of higher education institutions’ (HEI) entrants as a crucial factor that directly influences the admission efficiency, quality of education results, and future students’ life-long trajectories. Due to the conditions of uncertainty surrounding the decision-making process that determines the admission of entrants and the inability to independently assess the probability of potential outcomes, we propose the application of the machine learning (ML) model as an algorithm that provides decision-making support. The proposed model includes the support vector machine (SVM) stacking ensemble, which expands the input data set obtained using the Probabilistic Neural Network (PNN). The basic algorithms include four SVM ensemble methods with different kernel functions and Logistic Regression (LR) as a meta-algorithm. We evaluate the accuracy of the developed model in three stages: comparison with existing ML methods; comparison with a single-based model that comprises it; and comparison with a similar stacking model and with other types of ensembles (boosting, begging). The results of the designed two-stage PNN–SVM ensemble model provided an accuracy of 94% and possessed acquired superiority in the comparison stages. The obtained results enable the use of the presented model in the subsequent stages of the development of an intellectual support system for decision making regarding entrants’ admission.
Fpr2−/− Mice Developed Exacerbated Alcohol-Associated Liver Disease
Authors: Hardesty Josiah E. , Warner Jeffrey B. , Song Ying L. , Floyd Alison , McClain Craig J. , Warner Dennis R. , Kirpich Irina A.
Published: April 2023

Alcohol-associated liver disease (ALD) is the most common chronic liver disease and carries a significant healthcare burden. ALD has no long-term treatment options aside from abstinence, and the mechanisms that contribute to its pathogenesis are not fully understood. This study aimed to investigate the role of formyl peptide receptor 2 (FPR2), a receptor for immunomodulatory signals, in the pathogenesis of ALD. WT and Fpr2−/− mice were exposed to chronic–binge ethanol administration and subsequently assessed for liver injury, inflammation, and markers of regeneration. The differentiation capacity of liver macrophages and the oxidative burst activity of neutrophils were also examined. Compared to WT, Fpr2−/− mice developed more severe liver injury and inflammation and had compromised liver regeneration in response to ethanol administration. Fpr2−/− mice had fewer hepatic monocyte-derived restorative macrophages, and neutrophils isolated from Fpr2−/− mice had diminished oxidative burst capacity. Fpr2−/− MoMF differentiation was restored when co-cultured with WT neutrophils. Loss of FPR2 led to exacerbated liver damage via multiple mechanisms, including abnormal immune responses, indicating the crucial role of FPR2 in ALD pathogenesis.
The Autoimmune Rheumatic Disease Related Dry Eye and Its Association with Retinopathy
Authors: Shan Huimin , Liu Wenhui , Li Yangyang , Pang Kunpeng
Published: April 2023

Dry eye disease is a chronic disease of the ocular surface characterized by abnormal tear film composition, tear film instability, and ocular surface inflammation, affecting 5% to 50% of the population worldwide. Autoimmune rheumatic diseases (ARDs) are systemic disorders with multi-organ involvement, including the eye, and play a significant role in dry eye. To date, most studies have focused on Sjögren’s syndrome (one of the ARDs) since it manifests as two of the most common symptoms–dry eyes and a dry mouth-and attracts physicians to explore the relationship between dry eye and ARDs. Many patients complained of dry eye related symptoms before they were diagnosed with ARDs, and ocular surface malaise is a sensitive indicator of the severity of ARDs. In addition, ARD related dry eye is also associated with some retinal diseases directly or indirectly, which are described in this review. This review also summarizes the incidence, epidemiological characteristics, pathogenesis, and accompanying ocular lesions of ARD’s related dry eye, emphasizing the potential role of dry eye in recognition and monitoring among ARDs patients.
On the Significance of the ADNT1 Carrier in Arabidopsis thaliana under Waterlogging Conditions
Authors: Neri-Silva Roberto , Monteiro-Batista Rita de Cássia , Fonseca-Pereira Paula da , Nunes Mateus Dias , Viana-Silva Ana Luiza , Palhares Ribeiro Tamara , Pérez-Díaz Jorge L. , Medeiros David B. , Araújo Wagner L. , Fernie Alisdair R. , Nunes-Nesi Adriano
Published: April 2023

Among the adenylate carriers identified in Arabidopsis thaliana, only the AMP/ATP transporter ADNT1 shows increased expression in roots under waterlogging stress conditions. Here, we investigated the impact of a reduced expression of ADNT1 in A. thaliana plants submitted to waterlogging conditions. For this purpose, an adnt1 T-DNA mutant and two ADNT1 antisense lines were evaluated. Following waterlogging, ADNT1 deficiency resulted in a reduced maximum quantum yield of PSII electron transport (significantly for adnt1 and antisense Line 10), indicating a higher impact caused by the stress in the mutants. In addition, ADNT1 deficient lines showed higher levels of AMP in roots under nonstress condition. This result indicates that the downregulation of ADNT1 impacts the levels of adenylates. ADNT1-deficient plants exhibited a differential expression pattern of hypoxia-related genes with an increase in non-fermenting-related-kinase 1 (SnRK1) expression and upregulation of adenylate kinase (ADK) under stress and non-stress conditions. Together, these results indicated that the lower expression of ADNT1 is associated with an early “hypoxic status” due to the perturbation of the adenylate pool caused by reduced AMP import by mitochondria. This perturbation, which is sensed by SnRK1, results in a metabolic reprogramming associated with early induction of the fermentative pathway in ADNT1 deficient plants.
Reliability of a Pendulum Apparatus for the Execution of Plyometric Rebound Exercises and the Comparison of Their Biomechanical Parameters with Load-Matching Vertical Drop Jumps
Authors: Panoutsakopoulos Vassilios , Kollias Iraklis A.
Published: April 2023

The inability to control the body center of mass (BCM) initial conditions, when executing plyometric exercises, comprises a restrictive factor to accurately compare jumps executed vertically and horizontally. The purpose of the study was to present a methodological approach for the examination of BCM initial conditions during vertical drop jumps (VDJ) and plyometric rebound jumps performed with a pendulum swing (HPRJ). A system consisting of two force plates was used for the evaluation of VDJ. A bifilar pendulum, equipped with a goniometer and accelerometer, was constructed for the evaluation of the HPRJ. Kinematic parameters from both jump modalities were obtained by means of videography (100 Hz). Thirty-eight physically active young males executed VDJ and HPRJ with identical BCM kinetic energy at the instant of impact (KEI). Results revealed that participants produced higher power and lower force outputs at HPRJ (p < 0.01). The rate of force development was larger in VDJ, while hip movement was less in HPRJ. The use of the presented methodology provided the means to reliably determine the exact BCM release height during the execution of the examined jumps. This provided an accurate determination of the amount of KEI, being the main parameter of calculating load during plyometric exercise.
Longevity of System Functions in Biology and Biomimetics: A Matter of Robustness and Resilience
Authors: Mylo Max D. , Speck Olga
Published: April 2023

Within the framework of a circular economy, we aim to efficiently use raw materials and reduce waste generation. In this context, the longevity of biomimetic material systems can significantly contribute by providing robustness and resilience of system functionality inspired by biological models. The aim of this review is to outline various principles that can lead to an increase in robustness (e.g., safety factor, gradients, reactions to environmental changes) and resilience (e.g., redundancy, self-repair) and to illustrate the principles with meaningful examples. The study focuses on plant material systems with a high potential for transfer to biomimetic applications and on existing biomimetic material systems. Our fundamental concept is based on the functionality of the entire system as a function of time. We use functionality as a dimensionless measure of robustness and resilience to quantify the system function, allowing comparison within biological material systems and biomimetic material systems, but also between them. Together with the enclosed glossary of key terms, the review provides a comprehensive toolbox for interdisciplinary teams. Thus, allowing teams to communicate unambiguously and to draw inspiration from plant models when developing biomimetic material systems with great longevity potential.
Risk Evaluation of Cost Overruns (COs) in Public Sector Construction Projects: A Fuzzy Synthetic Evaluation
Authors: Chadee Aaron Anil , Martin Hector Hugh , Gallage Sihara , Banerjee Kailas Sekhar , Roopan Ryan , Rathnayake Upaka , Ray Indrajit
Published: April 2023

In the Small Island Developing States (SIDS), public sector infrastructure projects (PSIPs) fail to both meet targeted performance metrics and deliver on the intended benefits to society. In terms of the cost performance metric, cost overruns (COs) beyond the initial contract value are more of a norm than a unique occurrence. Therefore, to ensure economic sustainability for SIDS, and value for money on PSIPs, there is a need to investigate and evaluate the risk impacts on COs. The purpose of this research was to identify and evaluate the perceived cost overrun risk factors that are within the primary project stakeholders’ sphere of control, and to reduce the ongoing ambiguities that exist in the prioritization of these risks. This was achieved by extracting critical risk factors from selected comparative studies in developing countries to formulate a closed-ended questionnaire to be administered to construction professionals in Trinidad and Tobago. Thereafter, the process of fuzzy synthetic evaluation (FSE) was used to develop a risk model based on three tiers of risks: 11 critical risk factors, 3 critical risk groupings (CRGs) and an overall risk level (ORL). The results showed that the two highest-ranked critical risks were project funding problems and variations by client. The leading critical risk grouping was client-related risk (5.370), followed by professional-related risk (4.815) and physical risk (4.870). The ORL was 5.068. Based on the FSE’s linguistic scaling, the CRGs and the ORL are perceived to be high risks in PSIPs. This research adds to the CO body of knowledge in primarily three ways. Firstly, the study extends the comparative assessment previously undertaken in scholarship into the context of SIDS to build on the generalizability of this context-specific phenomenon. Secondly, the FSE evaluation undertaken provides a practical tool to be promoted for use in SIDS’ construction industry among practitioners to focus and prioritize the critical risks in the planning phases and improve on contemporary risk practices in the execution phases of projects. Finally, this quantitative model approach is recommended to supplement the traditional qualitative risk management practices adopted in SIDS, thus contributing towards the overall improved economic sustainability and viability of PSIPs.
Enhancing the Dynamic Stability of Pylons via Their Drag and Lift Coefficients by Finite Volume Method
Authors: Nguyen Van My , Chau Van Than
Published: April 2023

This study aimed to estimate the drag and lift coefficients of the long-span bridge pylon using the finite volume method (FVM). The k-ω turbulence model was applied to analyze the behavior of wind flow around the pylon, yielding drag and lift coefficient values with an error of 0.98% compared to a previous tunnel experiment. Four recommended cross-sections were proposed to reduce drag and lift forces acting on the pylon, including concave, convex, crossing, and chamfering cross-sections. The finding indicated that drag and lift coefficient decreased for all cross-sections. Cutting edges of concave, convex, and chamfering cross-sections with a ratio ranging from 0.2 to 0.3 has the greatest impact on reducing drag coefficient, while the crossing cross-section with a cutting ratio ranging from 0.2 to 0.25 has the lowest drag coefficient. The maximum reduction in drag and lift coefficients were 23.69% and 13.14% for concave and chamfering cross-sections. Thus, cutting edges of cross-sections is an effective method to enhance the aerodynamic stability of the pylon. Additionally, we evaluated drag and lift coefficients for different wind direction angles. The angles of 0, 30, and 90 degrees resulted in the highest drag coefficient, while the angle of 0 degrees and the angle of 90 degrees resulted in the lowest and highest lift coefficient, respectively. This study not only provides recommendations for cross-sections that reduce forces acting on the pylon but also provides the intensity of this reduction through corresponding estimation equations. In conclusion, concave and chamfering cross-sections are the most effective in reducing drag and lift coefficients, or, in other words, increasing the aerodynamic stability of the pylon.
Earthquake Analysis of an Old RC Minaret Retrofitting with Shape Memory Alloy
Authors: Matari Zakaria , Bourdim Sidi Mohammed El-Amine , Rodrigues Hugo , Kadri Tahar
Published: April 2023

Existing seismic vulnerability has become a topical of actuality, concerning both new and old buildings. Several techniques have been used to allow structures to better resist seismic events. In recent years, these have been so-called intelligent materials such as shape memory alloys (SMAs) due to their superelasticity and their ease in returning to their initial state after deformation, which can reach 10%. In the present article, nickel–titanium SMA is considered in a minaret of an old church transformed into a mosque to control the seismic response in terms of displacements, stresses and accelerations. The assessment of the seismic behavior was performed based on a modal and then transient analysis with Ansys software. The main objective was to determine the effectiveness of the addition of shape memory alloys by varying their number.
Impact of M-Sand on Rheological, Mechanical, and Microstructural Properties of Self-Compacting Concrete
Authors: Suriya D. , Chandar S. Prakash , Ravichandran P. T.
Published: April 2023

In construction Industries, superior fresh and hardened concrete qualities play a significant role in which self-compacting concrete (SCC) is widely introduced. On the other hand, considering the depletion of river sand, manufactured sand (M-sand), created by crushing rock deposits, has been recognized as viable. However, still, there is a lack of understanding of the strength aspect of SCC with M-sand replacement along with admixtures such as Alccofine and silica fume. Therefore, experimental investigations are conducted in SCC by partially and completely replacing river sand with M-sand. Furthermore, to reduce the negative impacts of cement, such as energy consumption and environmental pollution, 10% and 12% pozzolanic materials were added, such as silica fumes and alccofine. Moreover, to examine the impacts on rheological and mechanical properties, EFNARC guidelines were used and measured the compressive strength, impact resistance, bond strength, and flexural and splitting tensile strengths. The test results indicate that incorporating the M-sand as a full replacement in the mix increased the compressive strength by 6.82% for M50 grades of concrete compared to reference SCC after a 28-day curing period. Microstructural analyses such as SEM (Scanning Electron Microscope), EDS (Energy-Dispersive Spectroscopy), XRD (X-ray diffraction), and FTIR (Fourier Transform Infrared Spectroscopy) techniques were also used to study the hydration phase of the M-sand SCC mix when compared to the conventional SCC mix.
Smart Adaptive Homes and Their Potential to Improve Space Efficiency and Personalisation
Authors: Goessler Thomas , Kaluarachchi Yamuna
Published: April 2023

Over the last decades, population growth in urban areas and the subsequent rise in demand for housing have resulted in significant space and housing shortages. This paper investigates the influence of smart technologies on small urban dwellings to make them flexible, adaptive and personalised. The study builds on the hypothesis that adaptive homes and smart technology could increase efficiency and space usage up to two to three times compared to a conventional apartment. The present study encompasses a comprehensive semi-systematic literature review that includes several case studies of smart adaptive homes demonstrating various strategies that can be employed to enhance the functionality of small spaces while reducing the physical and psychological limitations associated with them. These strategies involve incorporating time-dependent functions and furniture, as well as division elements that can adapt to the changing needs of users in real-time. This review further categorises types of flexibility and adaptation regarding the size of the moving elements, the time that the transformation takes and whether it is performed manually (by a human) or automatically (by a machine). Results show that smart and adaptive technology can increase space efficiency by reducing the need for separate physical spaces for different activities. Smart technology substantially increases the versatility and multifunctionality of a room in all three dimensions and allows for adaptation and customisation for a variety of users.
Time-Varying Evolution Behaviors of Steel–Concrete Composite Girders with Differentiated Connectors
Authors: Zhu Yingjie , Chen Liying , Wang Chen , Liu Cheng , Li Zhengyuan
Published: April 2023

To improve the cracking resistance of a concrete slab in the hogging moment region, a new concept called uplift-restricted and slip-permitted (URSP) connection technology has been proposed. Several studies have been conducted on URSP connectors, but investigations into the time-varying evolution behaviors of composite beams with URSP connectors are still lacking. In this paper, three types of elaborate finite element models of composite girders with differentiated connectors and different construction methods were established. Simulation of the concrete shrinkage and creep effect was realized using a user subroutine based on an improved rate-type formulation. The performances of the composite girders in three schemes were analyzed and compared in both the construction and service stages. The results demonstrated that the URSP connection technique can effectively increase the prestressing efficiency and decrease the tensile stress of the concrete induced by dead loads and vehicle loads. With an increasing service time, the concrete shrinkage effect will enhance the advantage of the URSP connection technique, and the creep effect will reduce this advantage. Finally, parametric analyses were conducted, and a value of 0.2 is recommended for the URSP length ratio to promote practical applications.
Immunomorphological Patterns of Chaperone System Components in Rare Thyroid Tumors with Promise as Biomarkers for Differential Diagnosis and Providing Clues on Molecular Mechanisms of Carcinogenesis
Authors: Paladino Letizia , Santonocito Radha , Graceffa Giuseppa , Cipolla Calogero , Pitruzzella Alessandro , Cabibi Daniela , Cappello Francesco , Conway de Macario Everly , Macario Alberto J. L. , Bucchieri Fabio , Rappa Francesca
Published: April 2023

Hurthle cell (HC), anaplastic (AC), and medullary (MC) carcinomas are low frequency thyroid tumors that pose several challenges for physicians and pathologists due to the scarcity of cases, information, and histopathological images, especially in the many areas around the world in which sophisticated molecular and genetic diagnostic facilities are unavailable. It is, therefore, cogent to provide tools for microscopists to achieve accurate diagnosis, such as histopathological images with reliable biomarkers, which can help them to reach a differential diagnosis. We are investigating whether components of the chaperone system (CS), such as the molecular chaperones, can be considered dependable biomarkers, whose levels and distribution inside and outside cells in the tumor tissue could present a distinctive histopathological pattern for each tumor type. Here, we report data on the chaperones Hsp27, Hsp60, and Hsp90. They presented quantitative levels and distribution patterns that were different for each tumor and differed from those of a benign thyroid pathology, goiter (BG). Therefore, the reported methodology can be beneficial when the microscopist must differentiate between HC, AC, MC, and BG.
Probing the Potential of Defense Response-Associated Genes for Predicting the Progression, Prognosis, and Immune Microenvironment of Osteosarcoma
Authors: Huang Liangkun , Sun Fei , Liu Zilin , Jin Wenyi , Zhang Yubiao , Chen Junwen , Zhong Changheng , Liang Wanting , Peng Hao
Published: April 2023

Background: The defense response is a type of self-protective response of the body that protects it from damage by pathogenic factors. Although these reactions make important contributions to the occurrence and development of tumors, the role they play in osteosarcoma (OS), particularly in the immune microenvironment, remains unpredictable. Methods: This study included the clinical information and transcriptomic data of 84 osteosarcoma samples and the microarray data of 12 mesenchymal stem cell samples and 84 osteosarcoma samples. We obtained 129 differentially expressed genes related to the defense response (DRGs) by taking the intersection of differentially expressed genes with genes involved in the defense response pathway, and prognostic genes were screened using univariate Cox regression. Least absolute shrinkage and selection operator (LASSO) penalized Cox regression and multivariate Cox regression were then used to establish a DRG prognostic signature (DGPS) via the stepwise method. DGPS performance was examined using independent prognostic analysis, survival curves, and receiver operating characteristic (ROC) curves. In addition, the molecular and immune mechanisms of adverse prognosis in high-risk populations identified by DGPS were elucidated. The results were well verified by experiments. Result: BNIP3, PTGIS, and ZYX were identified as the most important DRGs for OS progression (hazard ratios of 2.044, 1.485, and 0.189, respectively). DGPS demonstrated outstanding performance in the prediction of OS prognosis (area under the curve (AUC) values of 0.842 and 0.787 in the training and test sets, respectively, adj-p < 0.05 in the survival curve). DGPS also performed better than a recent clinical prognostic approach with an AUC value of only 0.674 [metastasis], which was certified in the subsequent experimental results. These three genes regulate several key biological processes, including immune receptor activity and T cell activation, and they also reduce the infiltration of some immune cells, such as B cells, CD8+ T cells, and macrophages. Encouragingly, we found that DGPS was associated with sensitivity to chemotherapeutic drugs including JNK Inhibitor VIII, TGX221, MP470, and SB52334. Finally, we verified the effect of BNIP3 on apoptosis, proliferation, and migration of osteosarcoma cells through experiments. Conclusions: This study elucidated the role and mechanism of BNIP3, PTGIS, and ZYX in OS progression and was well verified by the experimental results, enabling reliable prognostic means and treatment strategies to be proposed for OS patients.
Treatment Strategy for Ultra-High-Risk Multiple Myelomas with Chromosomal Aberrations Considering Minimal Residual Disease Status and Bone Marrow Microenvironment
Authors: Suzuki Kazuhito , Yano Shingo
Published: April 2023

Despite the development of anti-myeloma therapeutics, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies, and autologous stem cell transplantation (ASCT), multiple myeloma remains incurable. A trial treatment combining four drugs—daratumumab, carfilzomib, lenalidomide, and dexamethasone—followed by ASCT frequently results in minimal residual disease (MRD) negativity and prevents progressive disease in patients with standard- and high-risk cytogenetics; however, it is insufficient to overcome the poor outcomes in patients with ultra-high-risk chromosomal aberration (UHRCA). In fact, MRD status in autografts can predict clinical outcomes after ASCT. Therefore, the current treatment strategy might be insufficient to overcome the negative impact of UHRCA in patients with MRD positivity after the four-drug induction therapy. High-risk myeloma cells lead to poor clinical outcomes not only by aggressive myeloma behavior but also via the generation of a poor bone marrow microenvironment. Meanwhile, the immune microenvironment effectively suppresses myeloma cells with a low frequency of high-risk cytogenetic abnormalities in early-stage myeloma compared to late-stage myeloma. Therefore, early intervention might be key to improving clinical outcomes in myeloma patients. The purpose of this review is to improve clinical outcomes in patients with UHRCA by considering MRD assessment results and improvement of the microenvironment.
Irreversible Electroporation for Liver Metastases from Colorectal Cancer: A Systematic Review
Authors: Spiers Harry V. M. , Lancellotti Francesco , de Liguori Carino Nicola , Pandanaboyana Sanjay , Frampton Adam E. , Jegatheeswaran Santhalingam , Nadarajah Vinotha , Siriwardena Ajith K.
Published: April 2023

Background: Irreversible electroporation (IRE) is a non-thermal form of ablation based on the delivery of pulsed electrical fields. It has been used to treat liver lesions, particularly those in proximity to major hepatic vasculature. The role of this technique in the portfolio of treatments for colorectal hepatic metastases has not been clearly defined. This study undertakes a systematic review of IRE for treatment of colorectal hepatic metastases. Methods: The study protocol was registered with the PROSPERO register of systematic reviews (CRD42022332866) and reports in compliance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA). The Ovid MEDLINE®, EMBASE, Web of Science and Cochrane databases were queried in April 2022. The search terms ‘irreversible electroporation’, ‘colon cancer’, ‘rectum cancer’ and ‘liver metastases’ were used in combinations. Studies were included if they provided information on the use of IRE for patients with colorectal hepatic metastases and reported procedure and disease-specific outcomes. The searches returned 647 unique articles and the exclusions left a total of eight articles. These were assessed for bias using the methodological index for nonrandomized studies (MINORS criteria) and reported using the synthesis without meta-analysis guideline (SWiM). Results: One hundred eighty patients underwent treatment for liver metastases from colorectal cancer. The median transverse diameter of tumours treated by IRE was <3 cm. Ninety-four (52%) tumours were adjacent to major hepatic inflow/outflow structures or the vena cava. IRE was undertaken under general anaesthesia with cardiac cycle synchronisation and with the use of either CT or ultrasound for lesion localisation. Probe spacing was less than 3.2 cm for all ablations. There were two (1.1%) procedure-related deaths in 180 patients. There was one (0.5%) post-operative haemorrhage requiring laparotomy, one (0.5%) bile leak, five (2.8%) post-procedure biliary strictures and a zero incidence of post-IRE liver failure. Conclusions: This systematic review shows that IRE for colorectal liver metastases can be accomplished with low procedure-related morbidity and mortality. Further prospective study is required to assess the role of IRE in the portfolio of treatments for patients with liver metastases from colorectal cancer.
Synthesis, Structure, and Spectroscopic Properties of Luminescent Coordination Polymers Based on the 2,5-Dimethoxyterephthalate Linker
Authors: Cammiade Aimée E. L. , Straub Laura , van Gerven David , Wickleder Mathias S. , Ruschewitz Uwe
Published: April 2023

We report on the synthesis and the crystal structure of the solvent-free coordination polymer CoII(2,5-DMT) (1) with 2,5-DMT ≡ 2,5-dimethoxyterephthalate which is isostructural to the already reported MnII and ZnII congeners (C2/c, Z = 4). In contrast, for M = MgII, a MOF with DMF-filled pores is obtained, namely Mg2(2,5-DMT)2(DMF)2 (2) (P1¯, Z = 2). Attempts to remove these solvent molecules to record a gas sorption isotherm did not lead to meaningful results. In a comparative study, the thermal (DSC/TGA) and luminescence properties of all the four compounds were investigated. The compounds of the MII(2,5-DMT) composition show high thermal stability up to more than 300 °C, with the ZnII compound having the lowest decomposition temperature. MII(2,5-DMT) with MII = MnII, ZnII and 2 show a bright luminescence upon blue light irradiation (λ = 405 nm), whereas CoII in 1 quenches the emission. While ZnII in ZnII(2,5-DMT) and MgII in 2 do not significantly influence the (blue) emission and excitation bands compared to the free 2,5-DMT ligand, MnII in MnII(2,5-DMT) shows an additional metal-centred red emission.
Effect of Cultivable Bacteria and Fungi on the Limestone Weathering Used in Historical Buildings
Authors: Balland-Bolou-Bi Clarisse , Saheb Mandana , Alphonse Vanessa , Livet Alexandre , Reboah Paloma , Abbad-Andaloussi Samir , Verney-Carron Aurélie
Published: April 2023

Limestone buildings in urban areas are weathered due to climatic factors, to pollution but also to biological activity. Many studies have focused on microbially-mediated precipitation of calcite but few on their influence on limestone dissolution rates. In this study, a cultivable approach for studying bacterial dissolution of limestone is proposed. The results show, for the first time, that limestone has selected a specific structure in the bacterial communities and that each bacterial class has its own metabolism inducing a different efficiency on the alteration of limestone grains. Cultivable bacterial and fungal strains in our study permit to considerably increase (by 100 to 1,000,000 times) the chemical weathering rates compared to laboratory or field experiments. Individually, the results bring information on the ability to alter limestone by dissolution. Moreover, taken together, a functional ecological adaptation of bacterial and fungal classes to the alteration of the limestone monument has been highlighted. In order to release calcium into solution, these strains slightly acidify the medium and produce low molecular mass organic acids during experiments, especially lactic and oxalic acids.
Prognostic Value for Perioperative Serum Total Cholesterol Level on Postoperative Long-Term Prognosis of Pancreatic Cancer: A Retrospective Clinical Study
Authors: Wang Han-Xuan , Ding Cheng , Huang Jin-Can , Ma You-Wei , Lyu Shao-Cheng , Lang Ren
Published: April 2023

Cholesterol correlates with occurrence and progression of pancreatic cancer and has predictive value for postoperative prognosis in various cancers. Our study intended to reveal the relationship between perioperative serum total cholesterol (TC) level and postoperative prognosis of pancreatic cancer. We retrospectively analyzed the data of pancreatic cancer patients who underwent surgical treatment at our hospital from January 2015 to December 2021. ROC curves between serum TC level at each time point and 1-year survival rate were drawn, from which study object and optimal cutoff value was determined. Patients were divided into low and high-TC groups, and perioperative data and prognosis were compared. Risk factors for poor postoperative prognosis were identified by univariate and multivariate analysis. Overall survival rates at postoperative 1, 2 and 3 years in the low and high-TC groups were 52.9%, 29.4%, and 15.6% and 80.4%, 47.2%, and 33.8% (p = 0.005), respectively. Multivariate analysis confirmed tumor differentiation degree (RR = 2.054, 95% CI: 1.396–3.025), pTNM stage (RR = 1.595, 95% CI: 1.020–2.494), lymph node metastasis (RR = 1.693, 95% CI: 1.127–2.544), and postoperative 4-week serum TC level (RR = 0.663, 95% CI: 0.466–0.944) as independent risk factors for prognosis of pancreatic cancer. We conclude that postoperative 4-week serum TC level has certain predictive value for long-term postoperative prognosis of pancreatic cancer.
Acquisition and Analysis of Excised Neocortex from Pediatric Patients with Focal Cortical Dysplasia Using Mesoscale Diffusion MRI
Authors: Fountain Chandler , Ghuman Harmanvir , Paldino Michael , Tamber Mandeep , Panigrahy Ashok , Modo Michel
Published: April 2023

Non-invasive classification of focal cortical dysplasia (FCD) subtypes remains challenging from a radiology perspective. Quantitative imaging biomarkers (QIBs) have the potential to distinguish subtypes that lack pathognomonic features and might help in defining the extent of abnormal connectivity associated with each FCD subtype. A key motivation of diagnostic imaging is to improve the localization of a “lesion” that can guide the surgical resection of affected tissue, which is thought to cause seizures. Conversely, surgical resections to eliminate or reduce seizures provided unique opportunities to develop magnetic resonance imaging (MRI)-based QIBs by affording long scan times to evaluate multiple contrast mechanisms at the mesoscale (0.5 mm isotropic voxel dimensions). Using ex vivo hybrid diffusion tensor imaging on a 9.4 T MRI scanner, the grey to white matter ratio of scalar indices was lower in the resected middle temporal gyrus (MTG) of two neuropathologically confirmed cases of FCD compared to non-diseased control postmortem fixed temporal lobes. In contrast, fractional anisotropy was increased within FCD and also adjacent white matter tracts. Connectivity (streamlines/mm3) in the MTG was higher in FCD, suggesting that an altered connectivity at the lesion locus can potentially provide a tangible QIB to distinguish and characterize FCD abnormalities. However, as illustrated here, a major challenge for a robust tractographical comparison lies in the considerable differences in the ex vivo processing of bioptic and postmortem samples. Mesoscale diffusion MRI has the potential to better define and characterize epileptic tissues obtained from surgical resection to advance our understanding of disease etiology and treatment.
Grid-Connected Converters: A Brief Survey of Topologies, Output Filters, Current Control, and Weak Grids Operation
Authors: Hollweg Guilherme V. , Khan Shahid A. , Chaturvedi Shivam , Fan Yaoyu , Wang Mengqi , Su Wencong
Published: April 2023

Grid-connected converters (GCCs) are used extensively for the integration of DC power sources with AC power sources. However, since it is a complex topic, there are many possibilities for regulating grid-injected currents, as well as different modulation techniques for generating full-bridge PWM voltages. The control techniques are directly related to the type of output filter, as well as to the topology of the converter, since a complex plant can require more sophisticated controllers to keep the system stable, and with good regulation performance. Furthermore, a discussion of the applicability of these converters in weak and very weak grids with high inductance content has recently been growing, which adds a greater degree of complexity to the control structure of the converter. In this brief overview are outlined some topics about topologies, output filters, and control, focusing on the current regulation of grid-connected converters. In addition, a discussion of the main challenges and critical areas in operating on weak and very weak grids is also presented.
Environmental Assessment of Hellisheidi Geothermal Power Plant based on Exergy Allocation Factors for Heat and Electricity Production
Authors: Díaz-Ramírez Maryori , Jokull Snorri , Zuffi Claudio , Mainar-Toledo María Dolores , Manfrida Giampaolo
Published: April 2023

The Hellisheidi geothermal power plant, located in Iceland, is a combined heat and power double-flash geothermal plant with an installed capacity of 303.3 MW of electricity and 133 MW of hot water. This study aimed to elucidate the environmental impacts of the electricity and heat production from this double-flash geothermal power plant. In this vein, firstly, the most updated inventory of the plant was generated, and secondly, a life-cycle assessment approach based on the exergy allocation factor was carried out instead of applying the traditionally used allocations in terms of mass and energy. The functional unit was defined as the production of 1 kWh of electricity and 1 kWh of hot water for district heating. The life-cycle stages included the (i) construction, (ii) operation (including abatement operations and maintenance), and (iii) well closure of the geothermal plant. All of the life-cycle stages from construction to dismantling were considered. Finally, the results on the partitioning of the environmental impact to electricity and heat with exergy allocations showed that most of the impact should be charged to electricity, as expected. Furthermore, the distribution of the environmental impacts among the life-cycle stages determined that the construction stage was the most impactful for the electricity and heat production. This result was attributable to the large consumption of steel that was demanded during the construction of the geothermal power plant (geothermal wells, equipment, and buildings). Impacts due to the abatement stage demonstrated that this stage satisfactorily reduced the total impact attributed to the three life-cycle stages of the geothermal power plant.
Correlations of Heat Transfer and Fluid Flow Data for Lattice Brick Settings in Tunnel Kilns
Authors: Almesri Issa F. , Alrahmani Mosab A. , Almutairi Jaber H. , Abou-Ziyan Hosny Z.
Published: April 2023

This paper proposes correlation equations of heat transfer and pressure drop for the design and operation of tunnel kilns loaded with lattice brick settings of different geometrical parameters in the form of Nusselt number and friction factor. The developed correlation equations considered parameters that were not investigated in previous studies, such as the relative roughness of the bricks and the stack channels, and they also extended the Reynolds numbers to a practical range that was not covered before in a simple, practical form. The correlation equations are valid for Reynolds number between 125 and 10,200, Prandtl number between 0.68 and 0.73, brick’s relative roughness between 0.23 and 0.93, voidage fraction between 0.48 and 0.653, and the geometrical parameters of the tested lattice brick settings. The achieved correlations of the Nusselt number and the friction factor are well compared with the available correlations in the literature in their valid range of parameters. It is found that Nusselt numbers and the friction factors for low-density are higher than those of high-density settings for all considered parameters except the voidage fraction. The effect of the considered parameters confirms that Nusselt numbers increase and the friction factors decrease substantially with the Reynolds number and slightly with the Prandtl number. At a constant Reynolds number, both the Nusselt number and the friction factor increase as the brick’s relative roughness is increased. Moreover, as the stack channel spacing is increased, the Nusselt number decreases, and the friction factor increases. The voidage fraction of the setting has a monotonic effect on both Nusselt numbers and friction factors. Nusselt numbers for high-density are higher than those for low-density settings as the voidage fraction varies.
Optimal Configuration of a Hybrid Photovoltaic/Wind Turbine/Biomass/Hydro-Pumped Storage-Based Energy System Using a Heap-Based Optimization Algorithm
Authors: Menesy Ahmed S. , Sultan Hamdy M. , Habiballah Ibrahim O. , Masrur Hasan , Khan Kaisar R. , Khalid Muhammad
Published: April 2023

Recently, renewable energy resources (RESs) have been utilized to supply electricity to remote areas, instead of the conventional methods of electrical energy production. In this paper, the optimal design of a standalone hybrid RES comprising photovoltaic (PV), wind turbine (WT), and biomass sources as well as an energy storage system, such as a hydro-pumped storage system, is studied. The problem of the optimal sizing of the generating units in the proposed energy system is formulated as an optimization problem and the algorithms heap-based optimizer (HBO), grey wolf optimizer (GWO), and particle swarm optimization (PSO) are applied to achieve the optimal sizing of each component of the proposed grid-independent hybrid system. The optimization problem is formulated depending on the real-time meteorological data of the Ataka region on the Red Sea in Egypt. The main goal of the optimization process is to minimize the cost of energy (COE) and the loss of power supply probability (LPSP), while satisfying the constraints of system operation. The results clarify that the HBO algorithm succeeded in obtaining the best design for the selected RE system with the minimum COE of 0.2750 USD/kWh and a net present cost (NPC) of USD 8,055,051. So, the HBO algorithm has the most promising performance over the GWO algorithm in addressing this optimization problem.
Application of Bio-Derived Alternatives for the Assured Flow of Waxy Crude Oil: A Review
Authors: Gabayan Ron Chuck Macola , Sulaimon Aliyu Adebayo , Jufar Shiferaw Regassa
Published: April 2023

High molecular weight paraffin/wax precipitates in the solution of crude oil when the surrounding temperature falls below the wax appearance temperature, which causes the problem of wax deposition in pipelines. To enhance the rheology of the crude oil and lessen wax deposition, pour point depressants (PPDs) and flow enhancers were utilized. These substances change the wax crystals’ morphology, reducing crystal interlocking and preventing wax agglomeration from facilitating wax dispersion. However, recent research prompted a further investigation to improve the performance of conventional polymeric PPD and to address wax accumulation in a safe and environmentally responsible way. This is because of their poor performance at high shearing, expensive preparations, limited biodegradability, and toxicity. The primary objective of this study is to provide a thorough summary of current studies on the use of seed oil extracts rich in unsaturated fatty acids as an alternative for polymeric PPD. Important studies on the use of nanoparticles to improve the performance of conventional PPD, as well as strategies put into place to overcome issues with nanoparticle application, are also highlighted. Finally, an outlook of potential research ideas to develop pour point depressants is provided.
The Effect of Biochar Amendment, Microbiome Inoculation, Crop Mixture and Planting Density on Post-Mining Restoration
Authors: Asmara Degi Harja , Allaire Suzanne , van Noordwijk Meine , Khasa Damase P.
Published: April 2023

Ecological restoration with a multispecies and multifunctional approach can accelerate the re-establishment of numerous ecosystem services. The challenges with land that is degraded, damaged, or destroyed post-mining are the low productivity of soil and the high potential for contaminants. Herein, we evaluated the multispecies and multifunctional approach to restoration strategy through a mixture of woody and herbaceous species, microsymbiont and biochar amendments, and plant spacing. The experiments were conducted using greenhouse and field trials located in Quebec, Canada. We used a mixture of tree species (Alnus viridis (Chaix) DC. ssp. crispa (Aiton) Turrill, Picea glauca (Moench) Voss, Populus tremuloides Michx. and Salix arbusculoides Andersson) and herbaceous species (Avena sativa L., Festuca rubra L. and Trifolium repens L.) on two types of gold-mine waste materials (fine tailing and waste rock). The biochar amendment and microbial inoculation were applied on both greenhouse and field trials. We found both positive and negative effects of plant spacing, biochar amendment and inoculation depending on their interactions. The net positive effect was shown by combining high plantation density, biochar, and inoculation factors on Alnus viridis ssp. crispa. Overall, plantation density was shown to be the most important factor in generating the net positive effect. We suggest that the mechanism was correlated with the improvement in microclimate through soil plant water conservation and microbial activity enhancement over soil temperature modification. Hence, we propose to put emphasis on microclimate improvement for accelerating the restoration processes, along with other combined factors, including microbial inoculation and biochar amendment.