bluuebunny/crossref_metadata_2025 huggingface dataset:
Ranolazine Improves Autonomic Balance in Heart Failure when added to Guideline-Driven Therapy
Authors: L. Murray Gary , Colombo Joseph
Published: November 2021

Background: The effect of ranolazine (RAN) on cardiac autonomic balance in congestive heart failure (CHF) was studied. Methods: Fifty-four CHF patients were randomized to (1) open-label RAN (RANCHF) added to usual therapy vs. (2) usual therapy (NORANCHF). Parasympathetic and sympathetic (P&S) measurements were taken at baseline and at 12 months. Results: A total of 16/27 (59%) patients in both groups had initially abnormal P&S measures, including high sympathovagal balance (SB), cardiovascular autonomic neuropathy (CAN) or both. High SB normalized in 10/12 (83%) RANCHF patients vs. 2/11 (18%) NORANCHF patients. SB became high in 5/11 (45%) NORANCHF vs. 1/11 (9%) RANCHF patients. CAN improved in 4/6 (67%) RANCHF patients vs. 5/7 (45%) NORANCHF patients. CAN developed in 1/11 (9%) RANCHF vs. 4/11 (36%) NORANCHF patients. Since improved P&S in RANCHF patients seemed independent of improved brain natriuretic peptide and impedance cardiography (BioZ) measurements, 5 day RAN was given to 30 subjects without CHF but with high SB or CAN. P&S improved in 90% of these subjects. Conclusions: RAN improves unfavorable P&S activity in CHF possibly by a direct effect upon autonomic sodium channels.
Patient Satisfaction Questionnaire After Transcatheter Aortic Valve Replacement
Authors: Agarwal Shikhar , Baig Imran , Eslami Amir , Riangwiwat Tanawan
Published: November 2021

Health-related quality of life (HRQoL) is a multi-dimensional concept that includes domains related to physical, mental, emotional, and social functioning. Kansas City Cardiomyopathy Questionnaire (KCCQ) is typically utilized to assess the HRQoL after TAVR
Right ventricle Outflow Tract Acceleration Time: Correlation with Left Ventricular Diastolic Function
Authors: V Baroncini Liz Andréa
Published: November 2021

Background: There are no available data about the measurement of acceleration time at the right ventricle outflow tract (AcT) and its relevance in the analysis of the left ventricular diastolic function (LVDF). Objective: To correlate AcT with echocardiographic parameters of LVDF. Method: Eighty-seven patients (58.4±14.5 years; 52% women) submitted to transthoracic echocardiogram assessing spectral and tissue Doppler of the transmitral flow and mitral annulus, AcT, left atrial volume (LAV), and pulmonary artery systolic pressure (PASP). Patients with systolic dysfunction of the LV and grades II and III diastolic dysfunction (DD) were excluded. Main analyses were performed using the Spearman’s Correlation Coefficient (SCC) and Pearson’s Linear Correlation Coefficient (PLCC). Results: A negative correlation between AcT value and age (PLCC – 0.36; Student’s t-test; p <0.001) and a positive correlation between AcT and E/A ratio (SCC 0.38; p<0.001), between AcT and E/e’ ratio (SCC 0.26; p=0.01), between AcT and E wave of the mitral flow (PLCC 0.36; p= 0.001) were found. LAV and PASP did not correlate with AcT. In patients with a normal diastolic function, AcT was higher when compared with the AcT in patients with Grade I DD (0.150±0.029ms versus 0.127±0.023ms; p<0.001; Student’s t-test). The threshold suggested in this subgroup of patients was 0.135s. Conclusions: The present study correlated, unprecedentedly, AcT with echocardiographic parameters of the LV diastolic function. AcT values lower than 0.135s were associated with grade I diastolic dysfunction and higher than 0.135s values were associated with normal diastole.
Turmeric and Fenugreek - Herbal Agents to Alleviate Sickle Cell Disease
Authors: Yunus Mohammed , Aljadar Rawda , Zaher Amr
Published: November 2021

Introduction: Sickle cell disease (SCD) is a genetic disorder with autosomal recessive inheritance causing abnormal hemoglobin. It is an important medical problem globally as well as in our community at Eastern province of Saudi Arabia. It accounts for large numbers of morbidity and to a lesser extent mortality. Several natural plant products over the world, which were known in some communities and their traditional healers, were studied and found to have properties in improving SCD manifestation. This research was planned to explore if any plant product under our study could prove being an effective anti-sickling agent for therapeutic use in SCD management. Objectives: Studying the effects of some plants on sickled RBCs as well as comparing between efficacies of these different plants. Material and Methods: The 49 fresh whole blood samples, extracted through venipuncture in EDTA tubes, were collected from known SCD patients whose homozygosity were confirmed by hemoglobin electrophoresis. These patients were not on recent blood transfusion or hydroxyurea, and aged 14 years or above of both sexes on clinical follow up. The dried rhizomes of turmeric (curcuma longa) powder and dried seeds flour of fenugreek (trigonella foenum-graecum) were used to evaluate the reversal type of anti-sickling activity on RBCs. Results: Out of 49 blood samples, 28 (57.1%) samples were from males and 21 (42.9%) samples from females. The average (±SD) age of the cases was 28.2 (±9.97) years with range 14 – 60 years. Significant anti-sickling activity was found using Turmeric rhizomes extract treatment with 66.81% reversal effect, and 61.28% anti-sickling action when fenugreek seeds extract was used. Conclusion: The findings of this study suggest that turmeric (C. longa) rhizome extract and fenugreek seed extract could have promising anti-sickling properties for SCD treatment.
Infectious Diarrhea, as a Valid Medical and Public, Worldwide Health Problematic
Authors: Monica Deac Liana
Published: November 2021

Acute diarrhea of infec­tious etiology, referred to gastroenteri­tis and is associated with clinical signs and symptoms including: nausea, vomiting, abdomi­nal pain and cramps, bloating, flatulence, fever, passage of bloody stools, tenesmus, and fecal ur­gency disorders [10]. Diarrheal illness is a problem worldwide, with substantial regional variation in the prevalence of specific pathogens [8]. In fact, Infectious diarrheal diseases, are the second leading cause of morbidity and mortality worldwide and can cause real public health problems. Such diarrhea was studied as a medical disorder, in a 3 year period, 2017-2020, in Transylvania region from Romania. It was found 3577 number of cases, almost during July to August. The case incidence for the disease arrived at 65%, in the entire summer season. The data were transmitted by 12 district Sanitary Polices, to the Public Health Center. This all were mostly diagnosed by the territorial family doctors and more than 50% , have need some days of hospitalization, because of several disease disorders. For this disorders it was used a specific adequate fluid and electrolyte replacement as key of the treatment, to managing diarrheal illnesses. Even so, 3 children under 5 year’s age died, because of severe complications. Organic failed was estimate to be the cause of their deaths. Clinical and epidemiological evaluation defined the severity and type of this illnesses. The detected infectious etiology for the acute diarrhea, where determined in authorized Microbiology laboratories, and there were identified: Shigella spp, Salmonella spp, Campylobacter spp, Yersinia spp, Rotavirus, Giardia. Most number of cases appeared in children in 63%, followed by elderly or adult people in 17% each, all data as quantified number of determined infectious diarrheas. Acute diarrheal illness had to be considered a major public health issue, against which control efforts are needed. Public health surveillance of infectious acute diarrhea, includes obligatory strategies of infection control. Good hygiene, hand washing, safe food preparation, and access to clean water are key factors in preventing diarrheal illness
Desarda repair no Mesh and Lichtenstein repair for inguinal hernia (A study of 2793 patients)
Authors: Rodrìguez Pedro Rolando Lòpez , Garcia Castillo Eduardo , Leòn Gonzàlez Olga Caridad , Satorre Rocha Jorge Agustin , Quiala Luis Marrero , Ceruto Ortiz Lais Angèlica
Published: November 2021

Introduction: The objective of this study is to compare the outcomes of Desarda repair no mesh and Lichtenstein repair for inguinal hernia. Methods: This is a prospective randomized controlled trial study of 2793 patients having 2936 hernias operated from January 2002 to December 2020.1434 patients were operated using Lichtenstein repair and 1359 using Desarda repair. The variables like age, sex, location, type of hernia, tolerance to local anesthesia, duration of surgery, pain on the first, third and fifth day, hospital stay, complications, re-explorations, morbidity and time to return to normal activities were analyzed. Follow up period was from 1-10 years (median 6.5 years). Results: There were no significant differences regarding age, sex, location, type of hernia, and pain in both the groups. The operation time was 53 minutes in Desarda group and 43 minutes in the Lichtenstein group that is significant (p<0.05).The recurrence was 0.4 % in Desarda group and 0.4 % in Lichtenstein group. But, there were 14 cases of infection to the polypropylene mesh in the Lichtenstein group, 7 of this required re-exploration. The morbidity was also significantly more in Lichtenstein group (5,1 %) as compared to Desarda group (3.1 %). The mean time to return to work in the Desarda group was 8.26 days while a mean of 12.58 days was in the Lichtenstein group. The mean hospital stay was 29 hrs. In Desarda group while it was 49 hours in the Lichtenstein group in those patients who were hospitalized. Conclusions: Desarda repair scores significantly over the Lichtenstein repair in all respects including re-explorations and morbidity. Desarda repair is a better choice as compared with Lichtenstein repair.
Safe Midline Diastema Closure in the Presence of Porcelain Veneered Central Incisors
Authors: Singh Parmjit , Garrett Antonio
Published: November 2021

Midline maxillary diastemas have been known to have a detrimental effect on facial aesthetics. Orthodontics can successfully close a diastema using fixed appliances. Porcelain restorations bonded with fixed appliances may suffer damage. A case is presented where a fixed appliance was used to close a midline maxillary diastema bypassing porcelain veneered central incisors. Palatal attachments were used to optimise tooth movements and the porcelain veneers were left intact.
Obesity and Clinical Activity in Psoriatic Arthritis Patients Treated with Synthetic Disease-Modifying Antirheumatic Drugs
Authors: Pinto Tasende Jose A. , Lorenzo Alvarez Jose M. , Iñiguez Ubiaga Carlota , Dominguez Luis Fernández , García Porrúa Carlos , J. Maceiras Pan Francisco , Guerra Vázquez Jose L. , Martínez Jose A. Mosquera
Published: November 2021

Introduction: Comorbidities are prevalent in psoriatic arthritis (PsA) and which may affect disease activity and response to therapy. Aims: To evaluate comorbidities among patients with PsA naïve to biologics, and their association with basal inflammatory activity status, before starting them. Methods: We performed a retrospective cross-sectional a study of cohort of patients with PsA (CASPAR criteria), treated with synthetic disease-modifying antirheumatic drugs. Patients were managed according to EULAR/GRAPPA recommendations, and the collected variables included demographics, clinical, serological, classical CV risk factors, and treatment. Disease activity was assessed using the Disease Activity Score for Psoriatic Arthritis and clinical DAPSA scores. The tests were two-tailed, with a significance level of <0.05. Results: A total of 416 patients were included in the study: 222 maintained remission or low disease activity being treated without biologics, and 194 who needed to be treated with bDMARD because they did not response well to csDMARD. From patients who were waiting to start biologics, 38.1% had obesity and had increased risk of MetS for age > 50 years old (OR 3.287 [95%CI: 1.258-8.591], p 0.015) and CRP > 0.5 mgr/dL (OR 2.684 [95%CI: 1.141-6.313], p 0.024) but not for cDAPSA>13 (OR 1.539 [95%CI: 0.695-3.409], p 0.288). DAPSA score was higher in patients with obesity, 20.3 (14.4) vs 13.8 (8.5), p0.010 and these patients had an OR for cDAPSA>13 of 3.15 [95%CI: 1.07-9.25], p 0.037). Patients with obesity had a higher frequency of DAPSA and cDAPSA MoDA-HDA (p = 0.022; p = 0.032). In the linear logistic regression analysis, a high-moderate DAPSA score was associated with obesity (p = 0.017), CRP (p <0.0001), and cDAPSA score with obesity (0.029) but not with CRP (p = 0.748). Obesity and corticosteroid treatment were independent factors for cDAPSA>13 and the presence of enthesitis for cDAPSA≤13. Conclusion: PsA patients who did not respond well to csDMARD had a higher prevalence of MetS, associated with age > 50 years and CRP higher than normal values. The DAPSA score was higher in patients with obesity and corticosteroid treatment. Enthesitis was more frequent in patients with low disease activity by DAPSA score.
Case Study of a Middle-Aged Woman’s OCD Treatment Using CBT and ERP Technique
Authors: Paliwal Deepshikha
Published: November 2021

Introduction: This is a case report of a middle-aged woman, who was experiencing “obsessive” thoughts related to the “Bindi” (decorative piece wear by women on the forehead) and cleaning “compulsions”. Present case report discusses the patient’s assessment, case formulation, treatment plan and the effectiveness of the CBT and ERP sessions in reducing OCD symptoms.

Methodology: The patient was treated with Cognitive Behavior Therapy (CBT) along with Exposure Response Prevention (ERP) technique. The assessment of the case was done with the Y-BOCS rating scale, Beck’s Depression Inventory, Obsessive Beliefs Questionnaire, and Behavior Analysis Performa which suggested the higher severity level of the patient’s symptoms. Parallel to the assessment sessions, detailed case history related to the onset of the problem, difficulties faced because of the disorder, childhood incidences, family chart, marital issues, and medical history were discussed with the patient. Based on the reported details, the case was formulated according to the Salkovoskis inflated sense of responsibility model. After the case formulation, the treatment plan was designed which involved ERP sessions and restructuring of the cognitive distortions (beliefs, thoughts, and attitude).

Results: After the completion of the twenty-five therapy sessions, the patient reported improvement in the coping of anxiety-provoking thoughts and reduced level of the washing compulsions. The effects of the therapy were checked and found maintained up to two months follow up.

Conclusion: CBT and ERP technique is an effective treatment in reducing obsessive and compulsive symptoms of the patient.
Reprint-The Effect of Bone Marrow Derived Mesenchymal Stem Cells on the Survival of Random Skin Flap on Sterptozotocin-Induced Diabetic Rats
Authors: Chehelcheraghi Farzaneh , Rezazadeh Khadijah , Anbari Khatereh
Published: November 2021

Background and Objective: Wound dressing and healing in diabetic patients is encountered with many problems. This study aimed to investigate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the survival of random skin flap (RSF) on Streptozotocin-induced diabetic rats (STZ) using an optical microscope. Materials & Methods: In this study, 60 male Albino Wistar rats were used (average weight 250-300 gr). The rats were divided into six groups: 1) Health-Non (HN), 2) Health-Cells (HC), 3) Health-Sham (HS), 4) Diabetic-Non (DN) that were became diabetic by injecting STZ 70 mg/kg intraperitoneally), 5) Diabetic-Sham (DS), and 6) Diabetic-Cell (DC). In all groups, the day of surgery was considered as the zero day, on the back area of animal, the flap was created with a size of 8 × 3 cm and the BM-MSCs were performed. The sampling was performed on day 7 after surgery from the region where Transitional Zone (TZ) necrosis was initiated. Results: BM-MSCs increased the number of blood vessels (P=0.009) and the histology parameters (wound demarcation P=0.0001, granulation tissue P=0.0001) significantly compared to the control group. But this increase was not significant in the area of the survival region. Conclusion: It was concluded that after treatment with BM-MSCs, the wound healing process in both non-diabetic and diabetic groups was increased in accordance with histological characteristics.
Biochemistry, Medicinal Properties & Toxicity of Acacia Nilotica Fruits
Authors: Omer Abdalla Kamal
Published: November 2021

Acacia nilotica tree is native to Africa, the Middle East and the Indian subcontinent. Due to its wide medicinal properties & uses this plant attracted the attention of many scientists. Its fruits are rich in more than 16 classes of different bioactive molecules & elements very beneficial for human health. These molecules & elements include tannins, saponins, phytosterols, cyclitols, alkaloids, anticoagulant agents, regulatory molecules, amines, mucilage, fibers, gums, proteins, various classes of amino acids, carbohydrates, terpenses, crude fats, oils, fatty acids & minerals. The fruits are used to treat various human disorders including cancers, heart & liver diseases, diabetes mellitus, malaria, asthma, arrhythmias, acquired immune-deficiency syndrome, coronavirus disease 2019, spleen disorders, for weight loss, colds, congestion, coughs, diarrhea, dysentery, fever, gallbladder, hemorrhage, hemorrhoids, leucorrhea, ophthalmia, sclerosis, tonsillitis, pharyngitis, skin eruptions smallpox and tuberculosis. Acacia nilotica fruits are very beneficial for human health, safe & effective to treat various human diseases if it is used in appropriate dose & period. It has been in use in Sudan & in other parts of Africa widely & safely for generations to treat various diseases without any reports of toxicity or adverse effects. Moreover, human body has efficient detoxification mechanisms to process and detoxify toxic substances and toxicity in human occurs only from known high toxic substances, overdose, regular and long period of using of herbs or medicines with known side effects. It is apparent that toxicity of acacia nilotica fruits comes from over dosage & longer than required duration of uses or regular consumption and the solvent/s as well. However, further works are needed by pharmaceutical industries to authentically formulate various components of the of acacia nilotica fruits to be used as medicines & supplements to enhance the therapy of several human diseases.
The Developments of Innovative Technologies of Focal Radiotherapy a Viable, Safe, and Effective Option of Treatment
Authors: Mojdeh Hajira , Hamidi Imamatullah
Published: November 2021

Objectives: To determine if the postoperative delivery of fractionated stereotactic radiotherapy (FSRT) for resection cavity for patients with single and resectable brain metastases is safe and effective. Methods: A prospective feasibility protocol was set up to include patients with single and resectable brain metastases who underwent surgery and had low risk profile according to RPA classification. Fractionated stereotactic radiotherapy was applied. Single dose: 3.8 Gy, total dose: 41.8 or 49.6 Gy. Results: There was no case of break due to clinical problems. There was no case of delay of FSRT. The onset acute toxicity was observed in 40 cases (76.9%), no grade 3 and more was seen. Local recurrence free survival was 32.6 months, local control rate at 6, 12, 18 and 24 months were 85%, 77.9%, 65.9% and 65.9%. Overall local failure occurred in 34.1% of patients. Overall survival rates at 6, 12, 18 and 24 months were 90.3%, 63.9%, 47.7% and 31.6%. Median survival was 18.3 months (13.8-22.8) and overall 17.3% were living at the time of last analysis. Distant control rates at 6, 12, 18 and 24 months were 49.4%, 38.2%, 25.5% and 22.3%. Median distant recurrence free survival was 6 months (0-12.0) with overall distant failure in 77.7% of patients. Conclusion: FSRT for surgical cavity might be one possible option in treatment of single and resectable brain metastases.
Survei Efektifitas Proses Pembelajaran Online Akibat Pandemi Coronavirus (Covid-19) Pada Mata Kuliah Senam Lantai
Authors: Kurniawan Ari Wibowo , Hasan Ahmad Nur Hamzah
Published: November 2021

Tujuan penelitian ini adalah untuk mengetahui tingkat keefektifan proses pembelajaran online pada mata kuliah senam lantai bagi mahasiswa Pendidikan Jasmani, Kesehatan dan Rekreasi angkatan 2019, Universitas Negeri Malang. Penelitian ini menggunakan rancangan penelitian deskriptif kuantitatif dengan metode survei. Sampel yang diambil dalam penelitian ini yaitu 60% dari jumlah populasi, yaitu 139 mahasiswa PJKR 2019. Pengumpulan data menggunakan instrumen angket atau kuisioner berbasis google form, dengan terdapat lima indikator di dalamnya (minat mahasiswa, kemenarikan, manfaat, teknologi, kualitas interaktif). Hasil penelitian ini dapat disimpulkan bahwa pembelajaran online pada mata kuliah senam lantai dapat dinyatakan cukup efektif diberikan pada mahasiswa PJKR 2019. Hal ini terbukti dengan perolehan hasil penelitian yang telah dilakukan dengan lima indikator, sebagai berikut: 99 mahasiswa dari 139 mahasiswa PJKR 2019 menyatakan cukup berminat mengikuti pembelajaran online pada mata kuliah senam lantai dengan persentase 71,22%; 59% atau 82 mahasiswa menyatakan pembelajaran online cukup menarik dilakukan; pembelajaran online juga dinyatakan cukup bermanfaat bagi mahasiswa PJKR 2019 dengan persentase 58% atau 81 mahasiswa menjawab cukup bermanfaat; pada indikator teknologi diperoleh hasil 79% dengan kategori sedang; pembelajaran online dinyatakan cukup interaktif pada mata pelajaran senam lantai dengan persentase 63,31%.
Survei Kreativitas Guru Penjaskes Dalam Menghadapi Pembelajaran Secara Daring di Sekolah Menengah Pertama
Authors: Apriyaldi  , Usra Meirizal , Yusfi Herri
Published: November 2021

Penelitian ini bertujuan untuk mengetahui kreativitas guru pendidikan jasmani olahraga dan kesehatan dalam menghadapi pembelajaran secara daring mata pelajaran penjaskes (PJOK). Kreativitas diperlukan dalam melakukan sesuatu seperti proses pembelajaran, dalam proses pembelajaran kreativitas sangat diperlukan, seseorang guru yang tidak memiliki kreativitas dalam mengajar tidak mungkin menciptkan peserta didik yang kreatif dan inovatif selama proses pembelajaran. Jenis penelitian ini merupakan deskriftif kuantitatif dengan data persentase dan metode yang digunakan merupakan metode survei. Populasi penelitian ini adalah seluruh guru PJOK SMP Negeri se-Kecamatan Inderalaya Utara Kabupaten Ogan Ilir. Sampel terdiri dari kepala sekolah dan guru PJOK dengan jumlah 97 sampel. Teknik pengumpulan data yang digunakan adalah angket dan dokumentasi. Teknik analisis data yang digunakan yaitu analisisi statistik persentase dalam bentuk tabel frekuensi dan histrogram. Berdasarkan hasil penelitian yang diperoleh dari kreativitas guru PJOK dalam menghadapi pembelajaran secara daring, maka diketahui untuk persentase kreativitas guru PJOK 90,0% dan untuk pembelajaran daring 90,1% Untuk keseluruhan indikator 90,2% hasil tersebut berarti termasuk dalam kategori baik untuk kriteria persentase kreativitas guru dalam menghadapi pembelajaran secara daring.
Is It Cost Effective to Obtain Fungal and Acid-Fast Bacillus Cultures during Spine Debridement?
Authors: Lambrechts Mark J. , Clair Devin D. St. , Li Jinpu , Cook James L. , Spence Bradley S. , Leary Emily V. , Choma Theodore J. , Moore Donald K. , Goldstein Christina L.
Published: November 2021

Study Design: Retrospective study.Purpose: To identify the rate of positive acid-fast bacillus (AFB) and fungal cultures during spine debridement, determine whether these infections are more common in certain spine segments, identify comorbidities associated with these infections, and determine whether the universal performance of fungal and AFB cultures during spine debridement is cost effective.Overview of Literature: Spine infections are associated with significant morbidity and costs. Spine fungal and AFB infections are rare, but their incidence has not been well documented. As such, guidance regarding sample procurement for AFB and fungal cultures is lacking.Methods: A retrospective review of medical record data from patients undergoing spine irrigation and debridement (I&D) at the University of Missouri over a 10-year period was performed.Results: For patients undergoing spine I&D, there was a 4% incidence of fungal infection and 0.49% rate of AFB infection. Steroid use was associated with a higher likelihood (odds ratio, 5.62; 95% confidence interval, 1.33–23.75) of positive fungal or AFB cultures. Although not significant, patients undergoing multiple I&D procedures had higher rates of positive fungal cultures during each subsequent I&D. Over a 10-year period, if fungal cultures are obtained for each patient, it would cost our healthcare system $12,151.58. This is compared to an average cost of $177,297.64 per missed fungal infection requiring subsequent treatment.Conclusions: Spine fungal infections occur infrequently at a rate of 4%. Physicians should strongly consider obtaining samples for fungal cultures in patients undergoing spine I&D, especially those using steroids and those undergoing multiple I&Ds. Our AFB culture rates mirror the false positive rates seen in previous orthopedic literature. It is unlikely to be cost effective to send for AFB cultures in areas with low endemic rates of AFB.
ROLE OF ΚB AND AP-1 TRANSCRIPTION FACTORS IN CHANGES IN NITRIC OXIDE PRODUCTION AND UTILIZATION IN THE HEART OF RATS UNDER CHRONIC FLUORIDE INTOXICATION
Authors: Akimov O.Y. , Karpik Z.I. , Oliynyk K.I. , Mishchenko A.V. , Kostenko H.V.
Published: November 2021

Fluorides, being hazardous contaminants of soil and drinking water, can get in excessive amounts into human and animal bodies. This is especially true for regions where the fluoride content in soils is very high, for example, Poltava, Dnipropetrovsk, and Kirovohrad regions in Ukraine. Excessive fluoride intake can change the rate of nitric oxide production. The impact of fluorides on changes in nitric oxide production and metabolism in the heart and the role of redox-sensitive transcription factors in these changes are poorly understood. The aim of this study was to determine the effect of activation of κB transcription factors and activator protein 1 on the activity of inducible NO-synthase, constitutive isoforms of NO-synthase, nitrite and nitrate reductase, arginase, concentration of nitrites, peroxynitrite and nitrosothiols in the heart of rats during chronic fluoride intoxication. Materials and methods. The study was performed on 24 adult male Wistar rats weighing 220-260 grams. Animals were randomly divided into 4 groups of 6 animals in each (control, chronic fluoride intoxication group, κB blockade group and activator protein 1 blockade group). The experiment lasted 30 days. We determined the activity of inducible NO-synthase, constitutive isoforms of NO-synthase, the concentration of peroxynitrite alkali and alkaline earth metals, the concentration of nitrites and nitrosothiols, the activity of nitrite reductase, nitrate reductase and arginase. Results. Chronic fluoride intoxication increases the activity of inducible NO-synthase by 1.74 times, does not affect the activity of constitutive isoforms and reduces the activity of arginase by 35.68% compared with the control group of animals. The concentration of nitrites in the heart of rats increases 1.73 times, peroxynitrite 1.43 times, and the concentration of nitrosothiols doubled. The use of κB transcription factor blockers and activator protein 1 reduces nitric oxide production from NO synthases and reduces the concentrations of all nitric oxide metabolites in the heart of rats under conditions of chronic fluoride intoxication. Conclusions. Activation of κB transcription factors and activator protein 1 during chronic excessive intake of fluoride leads to hyperproduction of nitric oxide in the heart of rats due to increased activity of inducible NO-synthase and nitrite reductases. Excess production of nitric oxide under chronic fluoride intoxication leads to the accumulation of nitrites, peroxynitrite and nitrosothiols in the heart of rats.
CHANGES IN THE ACTIVITY OF INDUCIBLE NO-SYNTHASE AND ARGINASE, THEIR RELATIONSHIP WITH THE LEVEL OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN CERVICAL MUCUS IN PREGNANT WOMEN, WHO UNDERWENT IVF AND ARE AT RISK OF PRETERM CHILDBIRTH
Authors: Likhachov V. K. , Shymanska Ya. V. , Dobrovolska L. M. , Akimov O. Ye. , Makarov O. H.
Published: November 2021

Introduction. Nitric oxide (NO) produces a wide range of bioregulatory effects. Imbalance in the ratio of the activity of inducible NO-synthase and arginase in favor of iNOS can lead to a pro-inflammatory reaction. At the risk of preterm childbirth, the content of proinflammatory cytokines increases both at the local and systemic levels. The aim of this work is to study the relationship between changes in the content of pro- and anti-inflammatory cytokines and the activity of inducible NO-synthase and arginase in the cervical mucus of women with in vitro fertilization (IVF), who are at risk of preterm childbirth. Materials and methods. The test group (TG) included 37 women, who underwent IVF and presented prognostic signs, indicating a high risk of preterm birth in the future. The control group (CP) consisted of 20 healthy pregnant women, who did not undergo assisted reproductive technologies. We determined the indicators of inducible NO-synthase activity and total arginase activity, as well as the level of pro- and anti-inflammatory cytokines in the mucus of the cervical canal of the participants at their 28-34 weeks of pregnancy. Results and discussion. The activity of iNOS in TG significantly increased (in 2.57 times) compared to healthy pregnant women (CP), while the activity of arginase, on the contrary, decreased significantly (in 1.91 times). There was a significant increase in the levels of pro-inflammatory cytokines INF-γ and TNF-α in the TG women, while they demonstrated the significantly reduced concentration of anti-inflammatory cytokine IL-10. In cervical mucus taken from TG women, positive correlations were found between an increase in the concentration of the proinflammatory cytokine INF-γ and an increase in iNOS activity, between a decrease in IL-10 levels and arginase activity, and a negative relationship between an increase in iNOS activity and a decrease in arginase activity. Conclusions. The detected cytokine imbalance in pregnant women, who underwent in vitro fertilization and were at risk of preterm childbirth, together with a impaired ratio of iNOS and arginase, indicates an inappropriate level of immunosuppression. These immune changes, by activating cellular responses of maternal immunity, can contribute to preterme childbirth.
INFORMATIVE VALUE OF COMPARATIVE ASSESSMENT OF GENERAL CLINICAL INDICATORS IN PATIENTS WITH DESTRUCTIVE CHOLECYSTITIS
Authors: Abbasaliev R.B.
Published: November 2021

Purpose: comparative assessment of clinical manifestations of the course of destructive calculous cholecystitis before surgical operation. Methods. The study involved 86 patients with destructive cholecystitis (55 women and 31 men). 18 patients with destructive cholecystitis made up group 1, and 14 healthy people formed the control group. Patients with cholecystitis underwent cholecystectomy. The age groups were as following: 18-25, 26-40, 41-60 and 61-75 years. Grouping patients by age and sex enabled to reveal related concomitant diseases and complications of cholecystitis. 48 patients underwent open cholecystectomy, and 38 had laparoscopic cholecystectomy. The study determined the quantitative parameters of various enzymes in blood samples from patients with destructive cholecystitis, and the control group. Results. Standard open cholecystectomy was performed on in 55.8% of cases; consequently, laparoscopic cholecystectomy was performed in 44.2% of cases. A retrospective analysis of the surgical interventions performed has demonstrated 54 (62.8% ) patients had gallstones as a leading cause in the development of cholecystitis; 15 (17.4%) patients had phlegmon, 11 (12.8%) patients had gangrene, 4 (4.7%) patients had polyps, and 2 (2.3%) had gallbladder hypertrophy and complete closure of the lumen. 18 patients who underwent cholecystectomy, had developed various preoperative complications: 13 of them had local peritonitis, 2 patients had partial intestinal obstruction, and 3 were diagnosed as having mechanical jaundice. Local peritonitis was found out as the most common preoperative complication. 16 people had various comorbidities and made 18.6% of all patients. 8 (9.3%) out of 16 of the patients had diagnosis of diabetes mellitus. Conclusion. It should be noted that among all patients who underwent cholecystectomy, various preoperative complications were diagnosed, but local peritonitis was the commonest one. Diabetes mellitus against the background of impaired motility or tone of the intestines, bile ducts and the gallbladder leads to cholestasis and gallbladder inflammation.
Mesothelioma with Nonbacterial Thrombotic Endocarditis: A Case Report
Authors: Verma Avatar , Bhatta Narendra , Mishra Deebya Raj , Acharya Achyut Bhakta , Shahi Rejina , LImbu Sion Hangma , Katuwal Srijan , Lama Urmila
Published: November 2021

Non-bacterial thrombotic endocarditis is a rare condition characterized by noninfectious vegetation on cardiac valves which are often associated with malignancy. It often presents with features of embolism rather than cardiac failure. These are usually seen in autoimmune conditions, disseminated intravascular coagulation, malignancy of gut and lung but has also been reported in other malignancies as well. This entity is rare but one must have a clinical suspicion of the disease especially in a patient suffering from malignancy presenting with the embolic phenomenon. In this report, we are presenting a case of non-bacterial thrombotic endocarditis in an inpatient with pleural mesothelioma, a rare malignant neoplasm arising from pleura in a 35 years old mason, and a rare association as well.
PENGARUH KOMPENSASI TERHADAP KEPUASAN KERJA KARYAWAN (BIRO DISTRIBUSI DAN TRANSPORTASI) PADA PT. SEMEN PADANG
Authors: Mardahleni Mardahleni
Published: November 2021

Perusahaan sangat penting sekali memperhatikan setiap sumber daya yang mereka miliki, terutama sekali karyawan, agar karyawan tetap semangat, berprestasi serta memiliki kepuasan kerja yang tinggi. Dalam rangka peningkatan kepuasan kerja, perusahaan dapat memilih beberapa cara yang sesuai dengan situasi dan kemampuan perusahaan, yang diantaranya adalah melakukan program promosi jabatan dan pemberian kompensasi. Salah satunya perusahaan yang telah mencoba melakukan cara tersebut adalah PT. Semen Padang. PT. Semen Padang memberikan kompensasi tepat pada waktunya dan sesuai dengan prosedur yang telah ditetapkan, baik itu kompensasi langsung yang berupa gaji, upah, bonus, insentif, maupun kompensasi tidak langsung yang berupa tunjangan-tunjangan.        Penulis dalam melakukan penelitian ini menggunakan 2 variabel yaitu Kompensasi (X) serta variable Y yaitu Kepuasan kerja karyawan pada PT. Semen Padang. Analisa dilakukan menggunakan alat analisa regresi Liniear Sederhana. Dengan metode ini dapat dilihat bagaimana pengaruh kompensasi terhadap kepuasan kerja baik secara parsial maupun bersama-sama.            Dari hasil analisa yang dilakukan maka dapat diketahui bahwa kompensasi memiliki t-hitungnya yaitu sebesar 2,807 dimana lebih besar dari α= 5 %. Jika dilihat secara bersama-sama memiliki pengaruh yang signifikan terhadap kepuasan kerja, dimana pengaruh ini dapat dilihat melalui f-hitungnya yaitu 7,881 pada signifikan 0,009. Persamaan regresi yang diperoleh yaitu : Y = 1,603 + 0,566X .
MENGUKUR PELUANG USAHA DISTRIBUTOR PUPUK DI PASAMAN BARAT UNTUK DIKELOLA PERUSAHAAN DAERAH MEKAR JAYA MADANI (PD. MJM)
Authors: Asraf Asraf
Published: November 2021

Ini adalah penelitian deskriptif yang menurut tujuannya bersifat penelitian terapan yaitu untuk melihat peluang usaha sebagai distributor pupuk di wilayah Kabupaten Pasaman Barat yang ingin dikelola  Perusahaan Daerah Mekar Jaya Madani (PD. MJM) milik Pemerintah Daerah Pasaman Barat. Penelitian dilakukan dikawasan Kabupaten Pasaman Barat. Metode penelitian dilakukan dengan pengumpulan data yang diperlukan dari berbagai sumber melalui survey, wawancara dan pengumpulan data lainnya dari instansi terkait seperti Dinas Perkebunan, Dinas Pertanian dan Dinas Inkoperindag Kabupaten Pasaman Barat. Data yang diperoleh dianalisa secara kualitatif dari aspek Tehnis, pemasaran, dan manajemen. Sedangkan analisa  kuantitatif pada aspek keuangan berupa analisa atas parameter keuangan melalui pengukuran NPV, IRR, Payback Period dan Net B/C ratio. Dengan kedua analisa ini akan dapat diukur tingkat kelayakan usaha dimaksud. Dari hasil penelitian ini disimpulkan bahwa usaha Distributor Pupuk oleh PD. MJM untuk wilayah Kabupaten Pasaman Barat memiliki prospek menguntungkan dan layak
PENGARUH KEPEMIMPINAN DAN KOMPENSASI TERHADAP KINERJA GURU SMA ISTIQOMAH SIMPANG AMPEK
Authors: Adriwilza Adriwilza
Published: November 2021

Penelitian ini dilakukan di SMA Istiqomah, Simpang Ampek, Pasaman Barat. Tujuannya untuk mengetahui pengaruh kepemimpinan Kepala Sekolah dan Kompensasi terhadap Kinerja Guru. Populasinya adalah guru-guru SMA Istiqomah yang berjumlah 45 orang. Karena populasi jumlahnya dibawah  100  orang  maka  seluruh  populasi  dijadikan  responden.  Tidak  ada  penarikan  sampel. Penelitian seperti ini disebut penelitian sensus. Hasil uji korelasi menunjukkan adanya hubungan seluruh variabel independen dengan variabel dependen. R2  menunjukkan nilai sebesar 59% yang berarti bahwa pengaruh kepemimpinan kepala sekolah dan kompensasi terhada kinerja guru hanya sebesar itu. 41% lainnya dipengaruhi oleh variabel lain yang tidak diteliti disini. Setiap variabel independen berpengaruh positif dan signifikan terhadap variabel dependen. Namun variabel paling berpengaruh  adalah  kepemimpinan  kepala  sekolah  dengan  koefisien  sebesar  0,534,  sedangkan koefisien  kompensasi  hanya  sebesar  0,278.  Uji  F  menunjukkan  kedua  variabel  independen berpengaruh positif dan signifikan terhadap variabel dependen.
Pengaruh Kepemimpinan, Lingkungan Kerja Dan Motivasi Kerja Terhadap Kinerja Pegawai Pada Dinas Kebudayaan Dan Pariwisata Kota Sawahlunto
Authors: Mantauv Citra Suci
Published: November 2021

Penelitian ini dilakukan di Dinas kebudayaan Dan Pariwisata Kota Sawahlunto. Tujuannya untuk mengetahui pengaruh kepemimpinan, lingkungan kerja dan motivasi kerja terhadap kinerja pegawai. Populasinya adalah semua pegawai Dinas kebudayaan Dan Pariwisata Kota Sawahlunto sebanyak 35 orang. Karena populasinya jumlahnya dibawah 100 orang maka seluruh populasi dijadikan responden. Dengan nilai konstanta    (α) adalah 1,307 sedangkan nilai koefisien kepemimpinan 0,157, lingkungan kerja 0,067 dan motivasi kerja 0,462 dan berdasarkan hasil analisis data dengan regresi linear berganda diketahui bahwa nilai R-squre sebesar 0,544. Uji f menunjukan ketiga variabel indenpenden berpengaruh positif dan signifikan terhadap variabel dependen.
Kepuasan Kerja Merupakan Variabel Intervening Pengaruh Antara Motivasi Kerja Terhadap Kinerja Pegawai (Studi Empirik di Badan Penanggulanan Bencana)
Authors: Mantauv Citra Suci
Published: November 2021

Penelitian ini dimaksudkan untuk melihat bagaimana motivasi kerja mempengaruhi kinerja pegawai dan melihat pula apakah kepuasan kerja berperan sebagai variabel intervening. Dari hasil penelitian ini didapatkan variabel motivasi kerja (x) berpengaruh signifikan terhadap kinerja pegawai (y) dimana koefisien regresinya adalah 0,372 dengan tingkat signifikan sebesar 0,000. Namun, nilai koefisien regresi variabel motivasi kerja (X) tersebut mengalami penurunan dari 0,763  menjadi 0,372. Variabel kepuasan kinerja (I) sebagai variabel intervening berpengaruh signifikan terhadap kinerja pegawai  (Y) dengan nilai koefisien regresi adalah 0,411 dan  tingkat signifikannya sebesar 0,000. Besarnya pengaruh motivasi kerja terhadap kinerja pegawai  (Y) adalah 0,543 (R2  = 5.43). Dengan kata lain terjadi peningkatan pengaruh variabel motivasi kerja terhadap kinerja pegawai (Y) sebesar 3.1% atau dari 2,33% menjadi 5,43%. Berarti dapat diinterprestasikan bahwa variabel kepuasan kerja (I) memediasi secara parsial (partial mediation) hubungan antara variabel motivasi kerja (X) terhadap kinerja pegawai (Y).  Kata Kunci : Motivasi Kerja, Kepuasan Kerja, Kinerja Pegawai
Pengaruh Persepsi Kualitas dan Citra Merek Terhadap Kepuasan Konsumen Mobil Toyota Avanza Di Kabupaten Pasaman Barat
Authors: Putra Eko
Published: November 2021

Penelitian ini dilakukan untuk mengetahui pengaruh persepsi kualitas dan citra merek terhadap keputusan konsumen. Populasinya adalah semua konsumen Mobil Toyota Merek Avanza di Kabupaten Pasaman Barat dan sampel yang diambil dalam penelitian ini sebanyak 60 orang konsumen yang ditemui. Teknik pengambilan data adalah dengan kuisioner yang dikuantifisir dengan skala likert. Hasil pengujian hipotesis menunjukkan bahwa semua variabel bebas berpengaruh positif terhadap variabel terikat. Dengan nilai konstanta  (α) adalah 1,240 sedangkan nilai koefisien persepsi kualitas 0,451 dan citra merek 0,263 dan berdasarkan hasil analisis data dengan regresi linear berganda diketahui bahwa nilai R-squre sebesar 0,467. Uji f menunjukan kedua variabel indenpenden berpengaruh positif dan signifikan terhadap variabel dependen sebesar 11.921. Kata Kunci : Persepsi Kualitas, Citra Merek, Keputusan Konsumen
PENGARUH KEPEMIMPINAN KEPALA SEKOLAH DAN BUDAYA ORGANISASI TERHADAP KINERJA GURU SMA NEGERI 1 SIMPANG EMPAT
Authors: Putra Endang Tirtana , Yunita Yelvia
Published: November 2021

Dunia pendidikan dewasa ini menghadapi tantangan berat khusunya dalam menghasilkan sumber daya manusia yang berkualitas dan memiliki daya saing yang tinggi dalam pasar tenaga kerja global. Kinerja guru sangat penting dalam mensukseskan program pendidikan nasional. Diantara faktor-faktor yang mempengaruhi kinerja guru adalah kepemimpinan kepala sekolah dan budaya organisasi. Penelitian ini menganalisa pengaruh kepemimpinan kepala sekolah dan budaya organisasi terhadap kinerja guru pada SMA N 1 Simpang Empat. Populasinya adalah para guru di sekolah ini yang berjumlah 82 orang karna jumlah populasi dibawah 100 maka semua populasi dijadikan responden. Pengkuran variabel dilakukan dengan seperangkat instrumen yang dikuantifisir dengan skala likert. Hasil analisis dengan regresi linier berganda menunjukkan hasil bahwa kepemimpinan kepala sekolah berpengaruh positif dan signifikan terhadap kinerja guru SMA Negeri 1 Simpang Empat. Begitu juga budaya organisasi berpengaruh positif dan dignifikan terhadap kinerja guru SMA N 1 Simpang Empat. Pengaruh Kepemimpinan kepala sekolah dan budaya organisasi memberikan kontribusi sebesar 50,1% terhadap kinerja guru SMAN 1 Simpang Empat dan sisanya sebesar 49,9% dipengaruhi oleh variabel lain. Hasil penelitian ini memberikan implikasi praktis kepada pihak SMAN 1 Simpang Empat agar kinerja guru dapat ditingkatkan, perlu dilakukan peningkatan pada kepemimpinan kepala sekolah dan budaya organisasi.

Kata Kunci : Kepemimpinan Kepala Sekolah, Budaya Organisasi, Kinerja Guru
PENGARUH LOCUS OF CONTROL DAN STRES KERJA TERHADAP KINERJA PEGAWAI DI DINAS KELAUTAN DAN PERIKANAN KABUPATEN PASAMAN BARAT
Authors: Erdawati Erdawati
Published: November 2021

Penelitian ini dilakukan di Dinas kelautan dan perikanan Kabupaten Pasaman Barat. Tujuannya untuk mengetahui pengaruh Locus Of Control dan Stres Kerja terhadap kinerja pegawai di Dinas Kelautan dan Perikanan Kabupaten Pasaman Barat. Populasinya adalah seluruh pegawai yang berjumlah 46 pegawai. Karena jumlah populasinya dibawah 100 orang maka seluruh populasi dijadikan responden, tidak ada penarikan sampel. penelitian ini disebut penelitian sensus. Hasil uji korelasi menunjukkan adanya hubungan seluruh variabel independen dengan variabel dependen. R2 menunjukkan nilai sebesar 55,7 % yang berarti bahwa pengaruh Locus Of Control dan Stres Kerja hanya sebesar 55,7 % sedangkan 44,3 %`lainnya dipengaruhi oleh variabel lain yang tidak diteliti disini. Setiap variabel independen berpengaruh positif dan signifikan terhadap variabel dependen. Namun variabel paling berpengaruh adalah stres kerja dengan koefisien sebesar 1,162, sedangkan koefisien locus of control hanya sebesar 1,138. Uji F menunjukkan kedua variabel independen berpengaruh positif dan signifikan terhadap variabel dependen.

Kata kunci : Locus Of Control, Stres Kerja dan Kinerja Pegawai
PENGARUH ORIENTASI KEWIRAUSAHAAN DAN ORIENTASI PASAR TERHADAP KINERJA PERUSAHAAN MELALUI KEUNGGULAN BERSAING SEBAGAI VARIABEL INTERVENING (SURVEY PADA UKM PANGAN DINAS PERINDAGTAMBEN KOTA PADANG)
Authors: Usvita Mega
Published: November 2021

Penelitian ini dimaksudkan untuk melihat bagaimana Orientasi Kewirausahaan dan Orientasi Pasar mempengaruhi Kinerja Perusahaan dan melihat pula apakah Keunggulan Bersaing berperan sebagai variabel intervening. Dari hasil penelitian ini didapatkan variabel orientasi kewirausahaan (X1) dan Orientasi Pasar (X2) berpengaruh signifikan terhadap Kinerja Perusahaan (Y) dengan tingkat signifikan sebesar 0,000. Variabel Keunggulan Bersaing (I) sebagai variabel intervening berpengaruh signifikan terhadap Kinerja Perusahaan (Y) dengan tingkat signifikannya sebesar 0,002. Besarnya pengaruh Orientasi Kewirausahaan (X1) dan Orientasi Pasar (X2) terhadap Kinerja Perusahaan (Y) adalah 0,543 (R2 = 54,3). Berarti dapat diinterpretasikan bahwa variabel Keunggulan Bersaing (I0 memediasi secara parsial hubungan antara variabel Orientasi Kewirausahaan (X1) dan Orientasi Pasar (X2) terhadap Kinerja Perusahaan (Y).

Kata Kunci :Orientasi Kewirausahaan, Orientasi Pasar, Kinerja Perusahaan, Keunggulan Bersaing
ANALISIS PENDAPATAN DAN POLA PENGELUARAN RUMAH TANGGA NELAYAN DI WILAYAH SASAK RANAH PASISIA KABUPATEN PASAMAN BARAT
Authors: Zalmi Zalmi
Published: November 2021

This study aimed to compare the amount of revenue as fishing and oil as farm laborers on fishing Sasak region, as well as knowing the pattern of household expenditure fisherman bouffant Pasisia. This study sphere is expected to provide information about the income of fishermen, is also expected to provide information on the government to determine strategies to improve the welfare of fishing communities in the region bouffant .Metoda this research is quantitative descriptive is to analyze the data in a way to describe or portray the collected data. The sampling technique in this research is purposive sampling the researcher sets of samples with specific considerations such as small fishermen who catch fish in the traditional way that has and has an additional procession. The number of samples in this study were 30 people. The result of this research is the average income level fisherman sasakpasisia sphere obtained from the sea is Rp 1,200,000 per month. While the average rat fisherman income as a laborer is Rp 1,350,000 per month. The total average income of fishermen from fishing and non-fishing is Rp 2,550,000 per month. And 71% contributed to household expenses tangga. Pengeluaran house fisherman bouffant Pasisia realm consisting of food and non-food expenditure. Where food expenditure 76% and 24% non-food. Thus fishermen household SasakPasisia Domains belonging to households with lower levels of well-being as food expenditure is greater than the percentage of non-food expenditure.

Keywords: Fishermen, Peasants, Revenue