Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center
Authors: Renaudier M. , Binois Y. , Dumas F. , Lamhaut L. , Beganton F. , Jost D. , Charpentier J. , Lesieur O. , Marijon E. , Jouven X. , Cariou A. , Bougouin W. ,   Paris Sudden Death Expertise Center group, Adnet F. , Agostinucci J. M. , Aissaoui-Balanant N. , Algalarrondo V. , Alla F. , Alonso C. , Amara W. , Annane D. , Antoine C. , Aubry P. , Azoulay E. , Beganton F. , Billon C. , Bougouin W. , Boutet J. , Bruel C. , Bruneval P. , Cariou A. , Carli P. , Casalino E. , Cerf C. , Chaib A. , Cholley B. , Cohen Y. , Combes A. , Coulaud J. M. , Crahes M. , Da Silva D. , Das V. , Demoule A. , Denjoy I. , Deye N. , Diehl J. L. , Dinanian S. , Domanski L. , Dreyfuss D. , Duboc D. , Dubois-Rande J. L. , Dumas F. , Duranteau J. , Empana J. P. , Extramiana F. , Fagon J. Y. , Fartoukh M. , Fieux F. , Gabbas M. , Gandjbakhch E. , Geri G. , Guidet B. , Halimi F. , Henry P. , Hidden Lucet F. , Jabre P. , Joseph L. , Jost D. , Jouven X. , Karam N. , Kassim H. , Lacotte J. , Lahlou-Laforet K. , Lamhaut L. , Lanceleur A. , Langeron O. , Lavergne T. , Lecarpentier E. , Leenhardt A. , Lellouche N. , Lemiale V. , Lemoine F. , Linval F. , Loeb T. , Ludes B. , Luyt C. E. , Maltret A. , Mansencal N. , Mansouri N. , Marijon E. , Marty J. , Maury E. , Maxime V. , Megarbane B. , Mekontso-Dessap A. , Mentec H. , Mira J. P. , Monnet X. , Narayanan K. , Ngoyi N. , Perier M. C. , Piot O. , Pirracchio R. , Plaisance P. , Plaud B. , Plu I. , Raphalen J. H. , Raux M. , Revaux F. , Ricard J. D. , Richard C. , Riou B. , Roussin F. , Santoli F. , Schortgen F. , Sharifzadehgan A. , Sharshar T. , Sideris G. , Similowski T. , Spaulding C. , Teboul J. L. , Timsit J. F. , Tourtier J. P. , Tuppin P. , Ursat C. , Varenne O. , Vieillard-Baron A. , Voicu S. , Wahbi K. , Waldmann V. 
Published: June 2022

Background

Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain death complicating OHCA, in unselected patients entered into a comprehensive real-life registry covering a well-defined geographic area.

Methods

We prospectively analyzed consecutive adults with OHCA who were successfully resuscitated, but died in intensive care units in the Paris region in 2011–2018. The primary outcome was organ donation after brain death. Independent risk factors were identified using logistic regression analysis. One-year graft survival was assessed using Cox and log-rank tests.

Results

Of the 3061 included patients, 136 (4.4%) became organ donors after brain death, i.e., 28% of the patients with brain death. An interaction between admission pH and post-resuscitation shock was identified. By multivariate analysis, in patients with post-resuscitation shock, factors associated with organ donation were neurological cause of OHCA (odds ratio [OR], 14.5 [7.6–27.4], P < 0.001), higher pH (OR/0.1 increase, 1.3 [1.1–1.6], P < 0.001); older age was negatively associated with donation (OR/10-year increase, 0.7 [0.6–0.8], P < 0.001). In patients without post-resuscitation shock, the factor associated with donation was neurological cause of OHCA (OR, 6.9 [3.0–15.9], P < 0.001); higher pH (OR/0.1 increase, 0.8 [0.7–1.0], P = 0.04) and OHCA at home (OR, 0.4 [0.2–0.7], P = 0.006) were negatively associated with organ donation. One-year graft survival did not differ according to Utstein characteristics of the donor.

Conclusions

4% of patients who died in ICU after OHCA led to organ donation. Patients with OHCA constitute a valuable source of donated organs, and special attention should be paid to young patients with OHCA of neurological cause.