bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation-Based Instructional Materials on Central Dogma of Molecular Biology: Basis in Studying Genetics for Grade 12 Learners
Authors: Cano Junar Sebua , Olvis Paul R. , Disca Berlita Y. , Docena Aida F.
Published: May 2022

The essence of Genetics lies in the understanding of the concepts of Central Dogma of Molecular Biology. Although these ideas are fundamental to the field, they are notoriously difficult to understand and visualize. While simulation-based instructional materials are found to improve the teaching-learning process in science education, little has been done to assess their effectiveness in teaching and learning the concepts of Central Dogma of Molecular Biology. Hence, this study aimed to examine the effectiveness of simulation-based instructional materials towards the learning performance of Grade 12 learners on the concepts of Central Dogma of Molecular Biology. This study utilized a mixed-method approach. Results of the pretest and posttest showed that the learners demonstrated from approaching proficiency to advanced mastery level on the concepts of Central Dogma of Molecular Biology. Furthermore, it was revealed that the pretest and posttest mean scores of the learners on the concepts differed significantly (p.05). The result of the semi-structured interview revealed that the learners were engaged in experiential learning with the use of simulation-based instructional materials. An action plan was designed based on the study to utilize the simulation-based instructional materials in the teaching-learning process.
Robot-mediated Culture Education: Users’ Reception
Authors: Shih Chung-ling
Published: May 2022

Culture education can use a myriad of media, and this research explores how a robot can be used for culture education. To conduct the research, a questionnaire-based survey was conducted on adult and non-adult users. The findings showed that the two groups of respondents when calculated together had a higher level of satisfaction with educational effectiveness and the significant value of the system (89%, 917/1030) than operational experience (84%, 862/1030) and the robot’s sensory appeal (77%, 797/1030). The findings suggested that respondents had attached greater importance to the significant value and educational function of the robot-mediated system. Gaps existed between the two groups regarding their responses to the robot’s sensory appeal (84% vs. 64%), interaction with the robot (85% vs.77%), and reflective assessments on the value of the system (91% vs. 85%). Despite the gaps, the robot-mediated culture educational system has proved to be effective as it is in line with Norman’s (2004) visceral, behavioral and reflective needs of emotional design by creating a sensory appeal, giving users delightful operational experiences, and yielding positive assessments. The implications derived from the findings shed light on the educational value of using the robot as an agent of culture education.
Dois Vivas para a Alfabetização
Authors: Olson David R.
Published: May 2022

Este texto é a transcrição da palestra ministrada pelo autor como vencedor do Prêmio Walter J. Ong por carreira extraordinária no campo da Ecologia das Mídias, na 22ª Convenção Anual da Media Ecology Association. PUC-Rio, 8-11 de Julho de 2021.
O Funcionamento Tecnológico da Suástica
Authors: Aronis Carolin
Published: May 2022

Dando sequência ao trabalho de Aronis e Aoki (2021) a respeito das suásticas como tecnologias de violência, este ensaio foca especificamente nas formas contemporâneas de aplicação das suásticas em campi estadunidenses, utilizando uma perspectiva teórica da Ecologia das Mídias para expandir os horizontes a respeito do funcionamento tecnológico da suástica em prol do antissemitismo. A autora examina o material e a mídia da suástica, além de seu processo de produção, para decompor sua natureza violenta, assediadora e ameaçadora – para a comunidade judaica das universidades americanas, bem como para outras potenciais comunidades minoritárias e raciais. Através de cinco lentes de exploração tecnológica, material e comunicativa – produção, dupla marcação, bias de espaço-tempo, (re)mediação e prescrição – a autora elucida como as suásticas expostas criam um efeito traumático para universitárixs de origem judaica. Isto pode auxiliar pesquisadorxs e professorxs a respeito do tema e sua cura.
Machine Learning Empowered Personality Predication System Encompassing
Authors: Shahi Sanchit , Shahi Rishabh Gautam , Kumar Mahendra
Published: May 2022

Today's corporate world focuses not only on the set of skills of the potential employees, but also on their respective personality. Personality helps you succeed in both your professional and personal life. Therefore, recruiters need to be aware of an individual's personality trait. While the number of job seekers is increasing exponentially, the number of positions is declining, making it difficult to manually add the best candidate for the right position to the candidate list by looking at your resume. This article explores a variety of machine learning approaches to efficiently predict the personality by the usage of Natural language processing (NLP) technology. The results showcase that Random-forest achieves higher accuracy than several other algorithms i.e. KNN, SVM and Naive Bayes. This system can be used in many business areas / areas that may require professional candidates. This system reduces the workload of the department (general workers, employment, and training and dismissal department).
THE INFLUENCE OF SOCIAL MEDIA TO LEARN ENGLISH IN YOUNG LEARNERS
Authors: Carrion Alexandra , Fernando Patricio Riera Hermida  , Jorge Daniel Barrera Moncada
Published: May 2022

This action research was developed in a private school in Ecuador. It aimed to explore how social media could foster students’ English skills. Due to the pandemic caused by Covid-19, all the exploration was online. The participants were students from 13 to 15 years old. Internet access and technological gadgets were essential aspects during this learning process because they allowed the students to learn and practice the target language differently. The students’ English level was A1 according to the diagnostic test they took at the beginning of the school year. The data was collected through pre and post-surveys, pre and post-tests, and rubrics. During this process, there were online sessions where the participants interacted with international students from some countries around the world to practice their English skills. As a result, the participants acquired more vocabulary and improved their interaction, accuracy, and writing organization. Furthermore, they manifested how useful was to include social networks such as Facebook, Instagram, and Twitter as part of their English lessons.
INVESTIGACIÓN, POLÍTICAS UNIVERSITARIAS DE FORMACIÓN DOCENTE Y CIUDADANÍA DIGITAL EN ENTORNOS VIRTUALES
Authors: Fernando Avendaño  , Susana Copertari  , Candela Avendaño
Published: May 2022

El trabajo que presentamos es una investigación interdisciplinaria, presentada ante la Secretaría de Ciencia y Tecnología de la Universidad Nacional de Rosario (UNR), (Argentina), radicada en el Instituto de Investigaciones de la Facultad de Humanidades y Artes (UNR), (Escuela de Cs de la Educación; Secretaría de Posgrado (Doctorado en Educación y Maestría Interinstitucional sobre Estudios en Construcción de Ciudadanía). Sustentada en el paradigma cuali-cuantitativo, con aportes del método etnográfico de trabajo de campo, tanto presencial como virtual (TAYLOR y BODGAN, 1987; GUBER, 2004; COPERTARI, 2021), desde el contexto de una Antropología de las políticas públicas (BALL, 1990; COPERTARI, 2021). Se focaliza en el estudio de una experiencia que se está llevando adelante en nuestra Universidad como Política Pública de Formación Docente en entornos virtuales (LITWIN, 1995), mediante la implementación de una Diplomatura, desarrollada en el Campus Virtual-UNR- SIED (Sistema Institucional de Educación a Distancia). Una política pública de Formación Docente a través de la "Diplomatura en Estudios Avanzados por Entornos virtuales de enseñanza y aprendizaje" (EVEA)". Se inició en el año 2021, con el propósito de brindar una formación a docentes de las 12 Facultades e Institutos Superiores de la (UNR), a fin de llevar adelante procesos de enseñanza y aprendizaje en otros formatos, además del tradicional de las clases presenciales. La iniciativa surge del Rectorado con la intención de poder dar respuestas a la crisis pandémica Covid 19, a las desigualdades educativas de todo tipo y a la exclusión, agudizadas en tiempos crisicos y críticos a nivel mundial. El objetivo fundamental consiste en analizar crítica y reflexivamente ¿cuál es la política académica y de gestión de la (UNR) en materia de educación a distancia (EaD)?, ya sea virtual o semipresencial. Desde la tecnología educativa y en el marco de la EaD se intenta indagar acerca de sus implicancias en la formación docente de cada unidad académica. Acercamos un análisis sobre el estado actual de los conocimientos sobre el tema, como etapa inicial de la investigación pensando en la centralidad de la inclusión educativa, cuando la virtualización de la enseñanza llegó para quedarse, casi con pretensiones universalistas (COPERTARI y LOPES NEVES, 2020).
Tensiones entre Teoría y Práctica, Presencialidad y Virtualización. Aportes desde la experiencia profesional
Authors: Gerardo M. Kahan  , Alejandra Soso
Published: May 2022

El presente trabajo tiene como finalidad dar a conocer el relato de una experiencia llevada a cabo en un espacio interdisciplinario de Formación Docente en tiempos de pandemia, denominado "Diálogos de La Techné Educativa", (Rosario-Santa Fe- Argentina). El objetivo de esta contribución consiste en reeditar esta experiencia de formación en la modalidad de Educación a Distancia (EaD) y Pedagogía de la virtualización, dónde participan expertos en educación y especialistas con experiencia y formación en entornos digitales. Surge en el 2020, en el marco de la crisis pandémica mundial -donde la virtualización de la enseñanza se instalaba-, a pedido de un grupo de "Docentes Autoconvocados" de la provincia de Santa Fe, de todos los niveles y modalidades del sistema educativo. Éstos deseaban aprender y enseñar con dispositivos digitales por  entornos virtuales de enseñanza y aprendizaje (EVEA), acompañados con profesores de la especialidad, tanto del Ministerio de Educación de Santa Fe, como de aquellos que  dictan Seminarios en Maestrías y Doctorados universitarios en Educación, a quienes se sumaron Directores de Maestrías y Doctorado, Maestrandos y Doctorandos de la Facultad de Humanidades y Artes de la Universidad Nacional de Rosario y de otras universidades nacionales y extranjeras. En uno de los 19 encuentros que se desarrollaron durante el año 2020, todos los días martes de 28 a 21 hs (desde julio a fines de noviembre) se selecciona la conferencia del 22 de Setiembre, de uno de los autores de este artículo, el Dr. KAHAN. El interés con este trabajo consiste en desgrabar la conferencia por una de las docentes participantes SOSO, en coautoría con el disertante y juntos reflexionar acerca de la vuelta a la presencialidad sobre: "Tensiones entre Teoría/Práctica y Presencialidad/Virtualidad". Revivir esta experiencia en la actualidad, es el gran desafío, dada la vigencia de los planteos realizados. Posicionados en el paradigma socio-crítico (FREIRE, 1997) finalizamos el trabajo con reflexiones entre el conferencista y la docente participante SOSO, con preguntas que nos invitan a pensar-nos para desnaturalizar todo aquello que nos vuelva a la "zona de confort" de lo conocido, antes de la Pandemia, para no cambiar nada.
Fire Alarm System
Authors: Riyono Putrie Aurelia , Saputra Aprilian Sasi Kirana Purwa , Ate Hendi Jadi , Rahman Fatur , Utomo Restu Mukti
Published: May 2022

Fire is an accident that often occurs in the community. For that we need a tool that can provide early warning of a fire. There are many types of fire alarms. We design a fire alarm system using a microcontroller. By using this fire sensor, if a fire is detected, the sensor will send a signal regarding the presence of a fire. Flame sensor will be connected to the microcontroller. In this study using a microcontroller in the form of Wemos D1 and a flame sensor as a fire detection sensor and as an indicator light. The flame sensor itself can detect waves of 760 nm – 1,100 nm. Wemos D1 which functions as a microcontroller will send a signal to turn on the buzzer as an alarm and a dynamo which is used to turn on the pump.
Analisis Perancangan Mesin Pemotongan Wire Berbasis Automatic Wire Cutting MC di PT. Mitsuba Indonesia
Authors: Dwiaji Yudhi Chandra
Published: May 2022

Stator Generator is a stator that uses a generator consisting of a coil and a magnet that emits an alternating voltage so that it can rotate the flywheel, the stator generator is a product of the development of the Stator Motor whose production demand is always increasing. The Stator Generator consists of Flywheel Assy and Stator Comp. In the Manufacture Stator Comp process, the longest production process is wire cutting. This research started from finding the problem of long production time. In the process of cutting wire, it is still done manually using cutting pliers by the production operator. To meet daily production needs, this wire cutting process requires two employees to carry out the production process with an ever-increasing target. From these problems, a wire cutting machine based on Automatic Wire Cutting was developed in order to get maximum and efficient production results. Calculations in material selection and cutter angle are also considered so that the results of the wire cutting process are stable and produce good cuts.
Common and newly discovered pathogens in the Israeli Mediterranean Sea mariculture
Authors: Smirnov Margarita , Ofek Tamir , Hershko Hanna , Ron Tetsuzan B.
Published: May 2022

In the last few decades, the farming of different fish species in Israeli mariculture gradually increased. This paper aims to present the last 15 years’ study results that define the most significant fish pathogens and evaluate their seasonal or annual occurrence. During this survey, three new pathogens were detected, described, and entirely or partially characterized (the articles in press).
Perbandingan Algoritma Fisherface dan Algoritma Local Binary Pattern Untuk Pengenalan Wajah
Authors: Amalia Nurul
Published: May 2022

Face recognition system is a system used to detect facial images, which is used to provide accuracy in a system used for access control for facilities that require such a security system. However, it is not uncommon to find problems in the face recognition process, such as the difficulty of the system to recognize faces if similar training data are found. In addition, there are difficulties in the face recognition process due to the lack of the number of images and/or poses of the training data images which results in the system not being optimal in recognizing faces. Several methods were proposed to create a reliable facial recognition system, such as Fisherface and Local Binary Pattern. The advantage of using the Fisherface method is that the processing time is relatively fast. This is because the fisherfaces process uses a matrix process. In addition to the fisherface method, the Local Binary Pattern method is also used in facial recognition systems. This method is also known to be quite easy and efficient in its application to obtain facial image characteristics. With the advantages and disadvantages of each of the above methods, the author will conduct a comparative test between the two methods to measure the level of accuracy of each method. In this study, two algorithms are used, namely the Fisherface algorithm and the Local Binary Pattern algorithm. Where the Fisherface algorithm is a derivative of FLD combined with (PCA). PCA is in charge of reducing input data to simplify and speed up the process and FLD is in charge of producing a distribution matrix to facilitate classification and recognition. In addition to the fisherface method, the Local Binary Pattern algorithm is also used in the face recognition system. LBP is defined as the comparison of the binary value of the pixel at the center of the image with the 8 values ​​of the surrounding pixels so that the test image can be matched with the reference image. This research is useful for the development of facial recognition systems to be precise in the selection of methods, to minimize the occurrence of errors in the face recognition process. As well as getting a high level of accuracy and speed in facial recognition
Sistem Pendukung Keputusan Perekrutan Internal Audit Officer (Audit) Menerapkan Kombinasi Metode AHP dan MABAC
Authors: Panjaitan Siti Aspah
Published: May 2022

PT. Mahkota Group, Tbk and its subsidiaries own a number of palm oil processing mills located in North Sumatra and Riau. Mahkota Group companies need an Internal Audit Officer (AUDIT). Internal Audit is a job position whose function is to audit all balance sheet transactions in the company. An effective recruitment process is expected to be able to attract AUDIT candidates who truly meet the needs. In this era of technological advances, the process of recruiting employees can use the help of computer applications such as decision support systems. Leaders often face difficulties in recruiting because they are still using the manual system. One of the appropriate solutions to these problems is to use a Decision Support System (DSS). The Decision Support System (SPK) can assist the company in recruiting the right members of PT. MAHKOTA GROUP, Tbk and increase the efficiency of the decision. The AHP method is used to calculate the weighting of the criteria, and produces a reject rate as the main criterion, the MABAC method investigates the compatibility in discrimination between a set of alternative value data on certain criteria described in the Decision Matrix (DM), using the AHP method the criteria with the highest value variation will get the highest weight , While the MABAC method is used for ranking, the effect of maximizing and minimizing criteria on the evaluation results is considered separately. The selection of the best alternative is based on considering the ideal and anti-ideal solutions
Primary pre-hospital triage of patients with COVID-19
Authors: Cherkashin MA , Berezin NS , Berezina NA , Nikolaev AA , Kuplevatskaya DI , Kuplevatsky VI , Rakova TM , Shcheparev IS
Published: May 2022

The COVID-19 pandemic affected every sector of society, radically altering the work of health systems throughout the world. In the situation of the mass influx of patients seeking medical care that was hard to control, the issue of the widespread adoption of the medical sorting (triage) principles became urgent within weeks. The review provides analysis of 49 publications dealing with various aspects of arranging pre-hospital triage. The dynamic changes in approaches to triage, its objectives and technologies, as well as in the contribution of various X-ray imaging methods depending on the evolving experience of working with the novel infection, are of great interest. The search for literature in Russian and English published before March 10, 2022 was performed in a number of databases (Embase, Medline/PubMed, Researchgate, medrxiv.org, RISC). The search was performed using the following keywords: COVID-19, coronavirus, коронавирус, SARS-COV-2, 2019nCOV, lung ultrasound, computed tomography, computerized tomography, компьютерная томография, СT, triage, сортировка. The strategy of establishing pre-hospital triage centers or stations in case of pandemic makes it possible to reduce both the burden on the emergency departments and the occupancy rate for inpatient services. Quick access to various imaging methods (X-ray imaging, lung ultrasound or computed tomography) greatly facilitates taking clinical decisions, and could be considered beneficial in the current extraordinary situation.
Neurophysiological assessment of speech function in individuals having a history of mild COVID-19
Authors: Gulyaev SA , Voronkova YuA , Abramova TA , Kovrazhkina EA
Published: May 2022

Establishing a link between the objective research data and the thought process is one of the major issues of modern neurophysiology. The study was aimed to find an opportunity to perform objective analysis of the causes of cognitive impairment in individuals having a history of mild novel coronavirus infection by solving the inverse EEG problem. A total of 38 COVID-19 survivors were assessed, who had returned to work. The control group included 33 healthy individuals. EEG was recorded using a 128-channel system with an average reference. The data obtained were subjected to the EEG microstate segmentation and converted using the algorithm for solving the inverse EEG problem implemented in the sLORETA software package. In individuals with no history of COVID-19 being in a state of relaxed wakefulness, the component of rhythmic activity within Brodmann area 47, responsible for perception and realization of music, was found in all classes of EEG microstates (0.01 < p < 0.05; χ2-test). Auditory-speech load was characterized by rhythmic activity within areas 22, 23, 37, 39, 40, 44, 45, and 47. In individuals having a history of novel coronavirus infection being in a state of relaxed wakefulness, rhythmic activity within areas 22, 37, 39, 40 was detected. Under auditory-speech load, there was rhythmic activity within areas 37, 39, and 41 (p < 0.05; χ2-test). Thus, alterations in realization of speech function in the form of the disordered sequence of switching on the main language centers were revealed in COVID-19 survivors.
Business judgment rule to directors against personal liability for breaches of some of their duties
Authors: Beja Xolisa
Published: May 2022

This article examines the extent to which s 76(4)(a) of the Companies Act 71 of 2008 protects directors against personal liability for breaches of their duties to act in the company’s best interests, with due care, skill and diligence. The essential substantive elements of s 76(4)(a) create (as a minimum) a business judgment rule. Generally, that rule provides a director with a defence against liability for a breach of his duty of care, skill and diligence if, when he acted (or omitted to act), he did so reasonably, honestly, with no self-interest and in the interests of the company. In analysing s 76(4)(a) as an embodiment of features of a traditional business judgment rule, this article briefly discusses how a similar rule in Australia is drafted and applied in practice by their courts. The article concludes that s 76(4) (a) creates protection for directors that is more than the protection that is provided by a traditional business judgment rule. This conclusion is based on the extensive nature and scope of authority and powers which s 66(1) of the Act grants to directors. In the same breath, however, s 76(4)(a) manages to make directors appropriately accountable to the company’s stakeholders, in keeping with some of the fundamental objectives and purposes of the Act.
Guarding against retirement funds’ arbitrary discretion when allocating death benefits: The urgent need for statutory guidelines
Authors: Marumoagae Motseotsile Clement
Published: May 2022

This article discusses the enormous power enjoyed by retirement funds’ boards to implement or reject deceased members’ clearly expressed wishes in their nomination forms or wills when distributing their death benefits. It demonstrates that boards are vested with wide discretion to apportion death benefits which, at times, is difficult to justify. Further, this leads boards to make incorrect allocations of death benefits by paying some beneficiaries less than others, completely excluding some from the distribution or allocating the entire benefit to one beneficiary. It argues that apart from requiring boards to honestly, rationally and reasonably allocate death benefits in line with the material facts placed before them, there is a need for legislative guidance that can effectively guide discretion exercised by boards of retirement funds when allocating death benefits.
Tax obligation and state legitimacy: A critique of the disconnect between state demands and people’s desiderata
Authors: Adedokun Kareem
Published: May 2022

The payment of taxes is one of the obligations recognised under any civil rule system. This informs why Nigeria, in its practice of constitutional democracy, emphasises prompt payment of tax as a basic duty of citizens to foster development, economic growth, and building. There is a fiscal contract through which citizens accept and comply with taxes in exchange for government’s effective services, the rule of law and accountability. It is a mutually beneficial process whereby citizens will receive improved governance while the government receives larger, more predictable, and more easily collected tax revenues. However, there is an obvious reversal of the fundamental obligations of the government, resulting in the sharp contrast between the state demands and people’s needs. This work, using doctrinal and survey sampling methods, critically examines the accountability and responsiveness of the government in its fiscal contract with the people, by embarking on a review of the correlation between the government’s obligations of good governance and the citizens’ civic duties of prompt payment of taxes. The review finds that the Nigerian tax system does not have a positive effect on nation-building as there is an apparent infrastructural deficit that impugns the taxpayers’ and investors’ confidence in the integrity of the tax system. Besides, there is no state machinery for an effective inclusive tax dialogue. Consequently, the initiation of the process of constructive engagements with the government is suggested to achieve an inclusive tax bargain which it is hoped will usher in a regime of responsive governance for sustainable development.
The need to address the challenges regarding the transfer of assets between occupational retirement funds operating in the municipal sector
Authors: Rasetlola Tshepiso Tshiamo
Published: May 2022

There are several industries where employers participate in more than one retirement fund, such as the municipal sector. Retirement funds that operate in such industries continually try to increase their membership leading to fierce competition for members. They often use their rules to attract new members while ensuring that they do not lose members who are currently paying contributions to them. These rules usually link membership of funds with the tenure of employment with participating employers. This article examines the legal framework that regulates the rivalry between retirement funds that operate within the same sector or are linked to the same employer. It assesses whether employees’ rights to freely associate with the retirement fund of their own is limited by retirement funds’ rules that ‘lock’ them into retirement funds that they joined upon their employment. This article highlights that the current legislation does not adequately deal with the voluntary transfer of assets between rival funds at the instance of the member. This article argues for the establishment of a legal framework that will adequately regulate the rivalry relating to retirement funds’ membership in sectors where the employer can participate in more than one retirement fund.
Review: Legal standing rules under the Companies Act, 2008: A critical review
Authors: Heyerdahl Jens
Published: May 2022

None
A Review on The Role of Technology Leadership in Teaching and Learning at Higher Learning Institutions in Post COVID-19
Authors: Abd Kadir Ermeey Bin
Published: May 2022

When it comes to technology leadership (TL), this paper reviews and discusses how important it is for the community in higher learning institutions (HLI) to be technology leaders, especially in teaching and learning post-COVID-19. Leadership issues in higher learning institutions are looked at in institutional development, faculty development, and student management.  TL person can play a role in these areas. Another topic is how technology changes how HLI is run post-COVID-19.  It includes a description of how technology changes how the higher institution is run. Increasing public awareness of the necessity for TL managers and doctorate students should aim at administrative leadership positions for current policy formation, strategic planning, administration, assessment, and institutional development implementation; and a discussion of the necessary skills and tactics for becoming a technology leader. Attributes of TL professionals should do more than just run distribution units or provide essential services. A prerequisite to drive change in institutional growth, employ technology in the learning process, manage resources, and collaborate effectively with academics to plan education. TL should be able to collaborate with institutional leaders on policy and planning for the deployment of instructional technology, faculty development, and institutional development. The positions that allow TL able to do this. The selected TL persons have formal training in technology in education, instructional media, instructional technology, instructional systems, communication in education, and all their related areas. They have also had previous job experience., so they are called Technology Leadership professionals.
Conectivismo en el aprendizaje en línea empoderando las competencias comunicativas docentes
Authors: Reyna Ledesma Victor Manuel , Lescano López Galia Susana , Boy Barreto Ana Maritza
Published: May 2022

El presente estudio, tiene como objetivo analizar las experiencias de aprendizajes en línea que se relacionan con el enfoque pedagógico del Conectivismo empoderando las competencias comunicativas digitales docentes. En el desarrollo de la investigación se consideró el enfoque cualitativo, a través de un análisis documental de artículos científicos publicados en revistas de alto impacto recolectado empleando la metodología PRISMA para una revisión sistemática. Los resultados nos demuestran que el rol del docente, a través de la mejora de sus competencias comunicativas y tecnológicas, participa con los estudiantes de una mayor interactividad con los contenidos y actividades del curso, organizando comunidades de aprendizaje en procesos de apertura, conectividad, autonomía y diversidad.
Multidisipliner Bir Bilim Dalı Olarak Biyoinformatiğe Genel Bir Bakış
Authors: KEKLİK Gülşah , ÖZCAN B. Devrim
Published: May 2022

Biyologların, DNA’nın üç boyutlu yapısından yola çıkarak hücre içindeki bilgilerin kromozomlar tarafından kuşaklar arası taşındığını keşfetmelerinin ardından gen projeleri üzerinde çalışmaları ve bunu yaparken bilişim teknolojilerinde kullanılan araçlardan yararlanmaları kaçınılmaz bir hal almıştır. Biyoinformatik, biyolojik sistemlerden elde edilen verilerin analizinin yapılması ve değerlendirilmesi için biyoloji, tıp bilimleri, bilişim teknolojileri, matematik ve biyoistatistiğin birleşiminden doğan multidisiplinler bir bilim dalıdır. Biyolojik dizilerin analizi için geliştirilen biyoinformatik bilimi; günümüzde biyoloji, genomik çalışmalar ve gen ekspresyon çalışmaları, tanı ve tedavi ile tanısı konmuş hastalıklara ilişkin ilaçlar geliştirme ve benzeri alanlarda kullanılmakta olup bilişim teknolojileri ve biyoistatistik biliminden oldukça faydalanmaktadır. Bu çalışmanın konusu kapsamında, biyoinformatik biliminin ortaya çıkışı, diğer disiplinler ile ilişkisi, uygulama alanları ve bir bilim dalı olarak gelecekte ne anlam ifade edeceği ele alınarak bu sürece ilişkin bilgiler verilecektir.
Using Music to Reduce Noise Stress for Patients in the Emergency Department: A Pilot Study
Authors: Short Alison E. , Ahern Nicole , Holdgate Anna , Morris Jenny , Sidhu Balwinder
Published: May 2022

High noise levels in the emergency department (ED) affect patient care and cause noise annoyance (stress) to patients. This pilot project aimed to reduce noise stress by offering patients in the ED a coping strategy: headphones and music. In this randomized controlled study, 30 patients meeting study criteria were recruited, with half undergoing the music intervention. This involved listening to music via headphones and an MP3 player from preloaded playlists in four relevant genres. All participants completed a pre- and post-self-report stress tool, a self-report noise disturbance scale, and visual analogue scales related to stress and music. Results showed a trend toward decreased negative affect scores in the intervention group. Positive affect scores remained constant or increased. Individual comments suggested participants’ enjoyment, distraction, and ‘‘escape’’ from the environment. Results suggested that music may be a beneficial intervention to reduce ED noise stress; however, further exploration is needed.
Duchenne Muscular Dystrophy in Male Child Diagnosed by Dystrophin Gene Deletion Test
Authors: Dornadula Giri Rajasekhar , Chennaboina Indira , Sanivarapu Gowthami , Konduru Gayathri , Amasa Anusha
Published: May 2022

Duchenne muscular dystrophy is an x-linked recessive disease, affecting 1 in 3600 to 6000 live male births, DMD is inherited musculoskeletal disease. DMD is named by a French neurologist Guillaume Benjamin Amand Duchenne in 1860. Dystrophies are caused by mutation in the dystrophin gene DMD (Xp21.2). Multiplex Ligation dependent Probe Amplification has been used as the initial diagnostic test of choice. MLPA can diagnose 70% of DMD patients, having deletions/duplications. Creatine kinase levels can also be used as a diagnostic marker for DMD. Genetic testing is mandatory irrespective of biopsy, results in the muscle biopsy is not required if the diagnosis is secured first by genetic testing. Current management of DMD involves physiotherapy and corticosteroid therapy, which delays loss of ambulation for 1-3 yrs.
Cerebral Sinus Venous Thrombosis (CSVT): A Case Report
Authors: B Vyshnavi. , T Chandana. , T Prathyusha. , Prabha. G Ramya Bala , T Rama Rao.
Published: May 2022

CSVT means cerebral sinus venous thrombosis here cerebral refers to the brain and sinovenous refers to the large vein that drain the brain. So, it is called as venous sinus. The system of vein found between the layers of dura matter the tough outer layer if your brain that lies directly under the skull. CSVT mainly occurs when a blood clot forms in the brain draining towards your heart .so, that the blood cells may break and leak the blood into the brain tissues forming a hemorrhage and also increasing the risk to cause of childhood and neonatal stroke. It is difficult to diagnosis with variable etiology and also it is multi conditional or multifactorial and prognosis, that require fine medical skills and a high suspicious index. It is a rare form of stroke the risk occurs mainly in new born, and also in the womb, teens, children up to 18 years of the age there is a risk for new mothers is especially high during the first few weeks after delivery. The symptoms appear in relation increase intracranial pressure and imitating a pesuditumor cerebri.
Inter Relation Between Diabetes Mellitus and Depression
Authors: Harshitha V. Sai , Ruthjerusha T. , Prathyusha T. , Balaprabha G. Ramya , Rao Balaprabha
Published: May 2022

Depression event is a few times higher in individuals with diabetes mellitus, most of the cases staying under-analyzed. The motivation behind this survey was to show the connections among melancholy and diabetes, bring up the significance of recognizing despondency in diabetic patients and distinguish the potential ways of tending to the two infections. Conceivable normal pathophysiological instruments as pressure and irritation were clarified, while accentuation was made on evaluating for misery in diabetic patients. A significant viewpoint for the diabetic expert would be the comprehension of the normal beginnings of diabetes and wretchedness and the familiarity with this very normal comorbidity, to work on the results of the two infections. In any case, the World Health Organization cautions us that there is "a significant hole between the weight brought about by mental issues and the assets accessible to forestall and treat them. It is assessed that four out of five individuals with genuine mental problems living in low and center pay nations don't get the emotional wellness benefits that they need". A multidisciplinary approach of the diabetic patient would assist with working on the results of illness, decline the quantity of DALYs and even mortality.
A Case Report of Pemphigus foliaceus
Authors: Jerusha Ruth , P Priyanka. , Chowdary G. Hemanth , Prabha.G Ramya Bala , Rao.T Rama
Published: May 2022

We report a case of the rarely seen disease pemphigus foliaceus in a 32-year-old female patient with a past medical history of superficial red raised lesion over the body face associated with itching and burning sensation for the treatment which has taken previously and healed pigmentation. She did not respond to topical steroids, and the condition flared up when oral steroids were tapered. Immunofluorescence biopsy and antibody titers can help establish the diagnosis. We discuss the clinical features, pathophysiology, histology, disease course, and treatment of Pemphigus foliaceus.
Stoneman Syndrome; A Comprehensive Review
Authors: L Monika. , Mohandas Karthik , S Sandra.
Published: May 2022

Stoneman syndrome also known as Fibrodysplasia ossificans progressiva (FOP), or Munchmeyer disease is an extremely rare autosomal dominant genetic disorder of connective tissue caused by heterozygous missense mutation in the bone morphogenetic protein (BMP) type I (Activin A receptor, type I [ACVR1]) leading to secondary skeleton formation, the joints get affected resulting in progressive loss of mobility. The median lifespan of patients suffering from FOP is approximately 40 years of age. Most patients are wheelchair-bound by the end of the second decade of their life and commonly die due to complications of thoracic insufficiency syndrome. There is no effective treatment for FOP; potential treatment may be based on future interventions that block ACVR1 gene. This includes most recent updates in the definition, epidemiology, signs and symptoms, etiopathogenesis, and treatment of FOP.
Evaluation of the Antioxidant Activity of Aqueous and Methanolic Extracts of Tetrapleura tetraptera Leaves (Schum. & Thonn.) Taub. (Fabaceae)
Authors: Oumar Yeo Sounta , Seraphin Konan N’dri , Traoré Mawa , Kalamourou Silué , Idrissa Doumbia , Allico Joseph Djaman , Adama Coulibaly
Published: May 2022

The objective of this study was to perform the determination of polyphenol and antioxidant activity evaluation of aqueous and methanolic extracts of Tetrapleura tetraptera (Fabaceae) leaves, a plant that is used in the traditional treatment of diabetes in Western Côte d’Ivoire. The quantitative estimation of total phenol contents by the colorimetric method showed that Methanolic Extract (ME) of leaves at 170 ± 0.88 mg GAE/g of extracts while Aqueous Extract (AqE) contains 140 ± 6.9 mg GAE/g of extracts. For flavonoids, the amount determined for ME is 87.33 ± 0.45 mg EQ/g of extracts, while AqE of leaves gave 54.66 ± 5.9 mg EQ/g. The results obtained indicate that ME of leaves from T. tetraptera contains more polyphenol compounds than AqE of leaves. The evaluation of the antioxidant activity of the various extracts was carried out according to two methods: the trapping of free radicals by the DPPH and the measurement of reducing power (FRAP). The antiradicalar power of ME of leaves gave an CI50 = 03.80 ± 0.97 μg/mL close to vitamin C (CI50 = 01.25 0.02 μg/mL) and higher than that of AqE of leaves with an CI50 = 08.60 ± 0.5 μg/mL. Similarly, for reducing power, ME of leaves with an CI50 = 04.24 ± 0.27 μg/mL, is similarly close to vitamin C (CI50 = 04.08 ± 0.01 μg/mL) and more effective than AqE of leaves (CI50 = 24.80 ± 0.37). So, this antioxidant activity could be an additional asset for the use of this plant in the traditional treatment of diabetes and other pathologies related to oxidative stress.
A Review on Schizophrenia: Outline and Treatment
Authors: Chaudhary Sarika , Chaudhary Stepi , Tyagi Vishal
Published: May 2022

Schizophrenia is a debilitating, genetic brain condition caused by anomalies that appear early in infancy and interrupt normal brain development. It has a lifetime risk of 1% and affects people of all ages, with around 10% dying by suicide. COVID-19 may raise the risk of mortality and morbidity in people with schizophrenia. Although antipsychotic medications of the first, second, and third generations are the most commonly prescribed treatments for schizophrenia, they are linked to major side effects such as tardive dyskinesia, oxidative stress, and EPS. Ayurvedic herbal medications and some dietary supplements score well in this category since they can be taken for a long time without causing major adverse effects and have antioxidant properties. Low potency first generation antipsychotics, sedating antihistamines, and benzodiazepines, as well as inhalable antipsychotics, oral and short acting injectable olanzapine, and ziprasidone, as well as low potency first generation antipsychotics, sedating antihistamines, and benzodiazepines, should be avoided or closely monitored for patients with COVID-19. Mentally ill patients with COVID -19 should be segregated if at all possible, and employees should be adequately protected.
Chemical Evaluation and Antimicrobial Activity of Leaf Powder of Cynodon dactylon
Authors: Komali D. , Alekya Padala , latha Y,Pushpa , Keerthana V.Vamsi , Sree B.Thanmai , Chowdary K.Pranavi , Panda Jagadeesh
Published: May 2022

The use of medicinal plants in the world and especially in India, contributes significantly to primary health care. Cynodon dactylon (L.) Pers. is a type of perennial grass that possesses great medicinal values. Whole plant of the Cynodon dactylon is traditionally used to treat painful and inflammatory conditions. The present study describes the phytochemical evaluation and antimicrobial activity of Cynodon dactylon. For the present studies, the chemical studies are done using ethanolic extracts and antimicrobial activities are done using ethanolic extract. Phytoconstituents present in Cynodon dactylon are Saponins, Tannins, steroids, alkaloids and Flavonoids. In this study the ethanolic extract of Cynodon dactylon was used to determine the antimicrobial activity against Escherichia coli, Bacillus subtilis. The antimicrobial activity was determined using the cup plate method. The diameter of the clear zone of inhibition surrounding the well was measured. It can be concluded that ethanolic extract of the leaf powder of Cynodon dactylon may be considered as an antimicrobial agent.
Multi-Targetted Molecular Docking Analysis of Selected Phytoconstituents of Bauhinia acuminata
Authors: Sireeshaa S. Muni , Neelimaa K. , Vinuthaa K.
Published: May 2022

Traditional medicine is often considered to be a kind of complementary or alternative medicine (CAM) nowadays. Therefore, documenting and identifying the herbs that are effective in treating various diseases is vital for future disease control programs. The study aims to perform Molecular docking analysis of the phytoconstituents of the Bauhinia acuminata named Quercetin, Bauhinone, Beta-sitosterol, and Kaempferol 3-glycoside with the target proteins with PDB IDs namely 2ITY, 1A52, 3L4U, IT02, 5COX, 6VYO involved in Lung cancer, breast cancer, anti-diabetes, anti-obesity, anti-inflammatory, and SARS COV-2. Chemsketch software, the study of the in-silico docking was done using Autodock.4.2 software and the binding interactions are visualized using Discovery studio 3.1. The docking scores and analysis of the interactions of the phytoconstituents with target proteins suggests that all the selected 5 phytoconstituents showed excellent binding to 2ITY and 5-COX as opposed to the standard drugs Erlotinib and Aspirin. In this study, it was concluded that the investigated phytoconstituents showed potent inhibiting activity, and the dock scores as opposed to standard as in Table 6, directly represent possible binding to the target proteins indicating their good biological activity as in lung cancer and anti-inflammatory action.
A Case Report of Disseminated Tuberculosis with Multiple Diagnosis in An Adolescent
Authors: Kothawar Gayathri , Neerudi Lavanya , Balaprabha Ramya
Published: May 2022

There are generally 4 different types of tuberculosis which include Pulmonary Tuberculosis, Avian Tuberculosis, Bovine Tuberculosis, and Miliary Tuberculosis. Among these, the severe and rare kind of tuberculosis is Miliary Tuberculosis which is also called Disseminated Tuberculosis which invades the bloodstream and spreads to all the body organs. This type of TB is most commonly seen in immunocompromised patients such as those with HIV infection, smokers, chronic alcoholics, and patients with other comorbidities. The lungs are the primary organs affected by tuberculosis, the infection can spread to other organs via the lymphatic system, a process known as lymphohematogenous dissemination. Lung, liver, spleen, bone marrow, kidney, adrenals, eyes, and thyroid are among these organs. Cough, shortness of breath, fever, abdomen pain, joint problems, pallor, and weight loss are all common symptoms. Complete blood count, chest X-ray, CT scan, Tuberculin skin test (PPD test), Thoracentesis, sputum examinations and cultures, Interferon Gamma Release Assays (IGRAs), Mycobacterial culture, and Polymerase chain reaction are some of the diagnostic procedures available (PCR). Polyserositis is sometimes linked to tuberculosis, a condition in which the pleura, pericardium, and peritoneum are inflamed, resulting in a severe effusion. Symptoms are comparable to those of tuberculosis (TB). Because it's linked to autoimmune illness, malignancies, and sepsis, diagnosing it might be difficult.
Formulation Development and Evaluation of Terbinafine Emulgel
Authors: Jonnalagadda Leela Prasanna , Devireddy Sai Kumar
Published: May 2022

Terbinafine is a broad-spectrum antifungal drug. The aim of the research was to develop and describe a Terbinafine emulgel using Carbopol 934 and HPMC K15M as a gelling agent. By avoiding the first pass metabolism, the objective behind the formulation was to avoid dosing frequency and to increase the stability and bioavailability. All the excipients were tested for compatibility study with drug, which revealed that there was no physical and chemical interaction occurred. The physicochemical properties of the developed emulgels were evaluated, such as colour, homogeneity, consistency, spreadability, pH value, rheological behaviour, drug content, drug release, and stability. The stability and particle size are being determined by zeta potential. In-vitro drug release permeation research studies using Franz-Diffusion cell. Carbopol 934 based emulgel formulations showed highest drug release in comparison with corresponding HPMC K15M based formulations. The highest drug release 89.97%was found in formulations of F7, which follows nonfickian mechanism. Study concludes that of Terbinafine can be delivered effectively by emulgel formulations.