bluuebunny/crossref_metadata_2025 huggingface dataset:
The Fact of How Leaders Influence on Employee Creativity in Indonesia
Authors: Nilasari B. Medina , Muhidin Salut , Prasetyo Ditho Dwi
Published: August 2022

Introduction/Main Objectives: Digitization in the Indonesian National Shipping Company requires employee creativity so it is necessary to know the extent of the role of transformational leadership. The purpose of this study is to analyze the effect of transformational leadership on employee creativity at the Indonesian National Shipping Company.  Background Problems: The demand for employee creativity is very high at this company engaged in ship transportation services because the use of technology and digitalization in the workplace environment is increasing to minimize physical contact when carrying out task activities. Therefore, the role of transformational leadership is needed in increasing employee creativity to generate innovative ideas and work behavior.  Novelty: Compared to previous studies, this study also examining perceived organizational support as a mediating variable of the effect of transformational leadership on employee creativity. Research Methods: The data used in this study are primary data. 200 respondents were obtained from Indonesian National Shipping Company who became the sample. Analysis of the data used to test the hypothesis is Structural Equation Modeling (SEM). Finding/Results: Transformational leadership affects employee creativity and the effect of transformational leadership on employee creativity can be mediated by perceived organizational support. In addition, the higher the employee's perception of perceived organizational support, the stronger the effect of transformational leadership on employee creativity.  Conclusion: Leaders who motivate, inspire, have quirky ideas, are willing to listen, and leaders who encourage employees to develop can increase employee creativity. The more leaders care about employees' opinions, leaders care about employee welfare, leaders are consistent with procedural justice, and fairness according to employee performance, the perceived organizational support will improve which will then strengthen the effect of transformational leadership on employee creativity.
The Change Has Come: How Transformational Leadership Makes Change Transition Successful in Islamic Banks?
Authors: Suryani Irma , Halimatussakdiah Halimatussakdiah , Amri Amri , Alfaridzi Muharam , Chayyara Riska , Sofa Nidia , Khatijatusshalihah Khatijatusshalihah
Published: August 2022

Introduction/Main Objectives: A major syariah regulation in Aceh province, Indonesia, has forced conventional banks to terminate their operation in the region, and following that Islamic Banks particularly in Aceh become popular and grow significantly. As a result Bank’s operational management has changed in Aceh province. Background Problems: As anticipated, uncertainty, confusion and insecurity impacted employee performance Novelty: Transformational leadership has long been associated with change process, therefore this research tried to validate the notion with the case of Islamic Banks in Indonesia particularly in Aceh Province which has never been studied before Research Methods: This research was conducted using quantitative approach, data were collected using online questionnaires from 135 active employees in Islamic Syariah Banks and hypothesis were then tested using SEM. Finding/Results:The results show that transformational leadership significantly affects job performance during the change process at Islamic Banks in Aceh Province and self-efficacy mediates the relationship Conclusion: The study confirms that transformational leadership does affect job performance during the change process.
Prolonged Intermittent Kidney Replacement Therapy
Authors: Levine Zoey , Vijayan Anitha
Published: August 2022

Kidney replacement therapy (KRT) is a vital, supportive treatment for patients with critical illness and severe AKI. The optimal timing, dose, and modality of KRT have been studied extensively, but gaps in knowledge remain. With respect to modalities, continuous KRT and intermittent hemodialysis are well-established options, but prolonged intermittent KRT is becoming more prevalent worldwide, particularly in emerging countries. Compared with continuous KRT, prolonged intermittent KRT offers similar hemodynamic stability and overall cost savings, and its intermittent nature allows patients time off therapy for mobilization and procedures. When compared with intermittent hemodialysis, prolonged intermittent KRT offers more hemodynamic stability, particularly in patients who remain highly vulnerable to hypotension from aggressive ultrafiltration over a shorter duration of treatment. The prescription of prolonged intermittent KRT can be tailored to patients’ progression in their recovery from critical illness, and the frequency, flow rates, and duration of treatment can be modified to avert hemodynamic instability during de-escalation of care. Dosing of prolonged intermittent KRT can be extrapolated from urea kinetics used to calculate clearance for continuous KRT and intermittent hemodialysis. Practice variations across institutions with respect to terminology, prescription, and dosing of prolonged intermittent KRT create significant challenges, especially in creating specific drug dosing recommendations during prolonged intermittent KRT. During the coronavirus disease 2019 pandemic, prolonged intermittent KRT was rapidly implemented to meet the KRT demands during patient surges in some of the medical centers overwhelmed by sheer volume of patients with AKI. Ideally, implementation of prolonged intermittent KRT at any institution should be conducted in a timely manner, with judicious planning and collaboration among nephrology, critical care, dialysis and intensive care nursing, and pharmacy leadership. Future analyses and clinical trials with respect to prescription and delivery of prolonged intermittent KRT and clinical outcomes will help to guide standardization of practice.
Antifungal Activity of Basidiomycete Carpophores Fungi Against Mycotoxigenic Species
Authors: Slama Awatef , Mezni Faten , Ayari Faten , Khaldi Abdelhamid
Published: August 2022

Abstract: This study aims the determination of antifungal activity and the flavonoids content of extracts from carpophores of some wild and cultivated fungi. The work was conducted on Wild fungi (Fomes fomentarius, Hericiumerinaceus, Schizophyllum commune, Plerotus ostreatus were collected in Tunisia from Ain Drahem (Northern west), Tbainia (Northern west), Kef Rand (Northern east), and Tunis regions. Cultivated mushroom were Pleurotus ostreatus and Lentinus edodes (Shiitake) species from Ain Drahem. Cultivation of these last two species was realized on logs of Populus sp. and Quercus canariensis respectively. The total flavonoid content of crude extract was determined by the aluminium chloride colorimetric method. The antifungal activity was tested against five fungal strains: Alternaria alternate, Penicillium olsonii, Ulocladium atrum, Phytophtora nicotianae, Aspergillus fumigates. Results showed significant differences between the fungal species and between the two extracts studied. Methanol extracts showed the highest flavonoid amount. The most important value was reached by methanol extract of Wild Plerotus ostreatus (2.3 mg RE/ml). Aqueous extract of studied mushrooms showed the most important antifungal activities. Fomes fomentarius Ain Drahem and cultivated P. ostreatus aqueous extracts showed the highest inhibitory rate again Alternaria alternata species (70% and 63.33% respectively).
How Can Government Protect Its Online Consumers Against Fraud?
Authors: Lone Irshad Ahmad , Hassan Nusrat
Published: August 2022

Abstract: India's developing e-commerce ecosystem integrates markets, transport providers, and government agencies, eliminates distributors and intermediaries, and connects directly with consumers through e-commerce platforms. With so many choices online, Criminals are always thinking of ways to commit fraud or other crimes. Fraudsters, pretending to be legitimate sellers, often lose the trust of their customers. The digital emptiness of this digital age is one of the biggest concerns when online consumers are easily swindled and unjustly imprisoned. As a responsible person, everyone should do some research before making a purchase, and keep records to ensure that this can hold the seller to his or her promises. There are many ways in which the Government can help its people to avoid and avoid such fraud.
Optimalisasi instagram sebagai daya dukung KPuK Malang dalam edukasi publik melalui sosial media
Authors: Ryan Saputra Andika , Selviana Rahmi Ari , Amnita Surya Listya Ningsih Irma , Sekar Pratiwi Nurma
Published: August 2022

Instagram is one of the social media that is currently growing rapidly. Optimal use of Instagram can provide positive benefits for users, and organizations are no exception. The initial findings obtained from Women’s Coalition for Leadership (KPuK) are that they still have not utilized the features on Instagram optimally. Two features that have not been utilized are the insight feature and the use of bio-Instagram. Based on these findings, the Service Team then continued to become an Instagram social media optimization program as a support for public education. The methods used to support this program include the planning stage, the implementation stage, and the evaluation stage. Furthermore, at the data collection stage, theService Team used data collection techniques of observation, interviews, and FGDs to collect data prior to program development. The results of this program make Instagram more active by utilizing the insight feature. In addition, by creating a database of KPuK products and placing them on bio-Instagram, it makes it easy for the public to access products about gender disparities. The success of the program can be seen from the availability of partners to continue the program that has been established.
Construction and identification of psychometric property self-regulated learning scale for university students
Authors: Hidayat Muhammad , Ardiyanti Difa , Dinni Siti Muthia
Published: August 2022

Previous studies state that self-regulated learning is a pivotal component in predicting students’ learning outcome. The present study aims to test the psychometric property of self-regulated learning scale to obtain a sound instrument. The procedure in this study included the scale construction, followed by psychometric property identification covering the content validity (using Aiken’s V and reliability test (Cronbach’s Alpha) of the data obtained from 203 respondents. The reliability coefficient of the final scale was 0.908, its discriminating power ranged between 0.307 and 0.626 with a mean score of 0.462. In other words, the self-regulated learning scale exhibit adequate psychometric property to measure university students’ self-regulated learning.
Job insecurity and innovative work behavior: The role of grit as a mediator
Authors: Ham Pricilla Mourine , Salendu Alice
Published: August 2022

The purpose of this study was to determine the role of grit as a mediator in the relationship between job insecurity and innovative work behavior in employees affected by policies due to the COVID-19 pandemic. This study is a quantitative study using an online questionnaire (Google Form) to collect data. The measuring tools used are the Innovative Work Behavior Scale, the Multidimensional Qualitative Job Insecurity Scale (MQJIS), and the Short Grit Scale (Grit-S). The participants of this study are employees in Indonesia who work in companies that implement new policies due to COVID-19. Through a nonprobability sampling technique, data were obtained for as many as 739 participants. The mediation test was carried out using the Macro PROCESS from Hayes model 4. The results showed that grit acted as a mediator in the relationship between qualitative job insecurity and innovative work behavior (B= -0.09, 95% CI [-0.13,-0.06]). Therefore, the results of this study can be used as a reference for companies to involve in measuring employee grit in the human resource management process
The changes of early childhood teachers' perception and practice in play using teacher community that supports children's play based on revised Nuri curriculum
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Haekyoung
Published: August 2022

Objectives The purpose of this study is to examine the change process of teachers' perception and practice according to the formation and operation of a teacher community based on the revised Nuri curriculum with cooperation with the research team. Methods Two teacher communities with 7 early childhood teachers was operated in cooperation with researchers for two months, conducting action research on changes in teachers’ understanding of play, recognition of roles, communication process, and utilization of collective intelligence. Results Changes through the teacher community have been classified into three categories. The first was the concerns about the play style and the teacher's role, the second was the change in teachers' perception and practice, and the third was the dynamic change in the play of children according to the teacher's support. Conclusions First, through the teacher community, teachers shared their concerns and sought advice from their peers to get ideas on how to operate and support play, and to reflect on their own teaching methods. Second, the teacher community facilitated that teachers supported young children to play a leading role in using play spaces and media, leading to immersion in play.
Mediating Effect of Internal and External Motivation between Ego-State and Creative Behavior of College Students of Department of Art Design in Hunan Province of China
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jiang Xiaohong , Ko Young Chun
Published: August 2022

Objectives For university students majoring in art design in Hunan Province of China, how personality traits and ‘internal and external motive’ influencing creative behavior relate to creative behavior is explored. And I would like to explore whether internal and external motive serve as partial or complete parameters between personality traits and creative behavior, or do not act as parameters. Methods The subjects of the study are college students majoring in art design in Hunan Province, and SPSS 25 program is used to perform reliability, correlation, and regression analysis of personality traits, internal and external motives, and creative behavior. That is, in the regression analysis, a simple regression analysis of internal or external motives(dependent variables) according to the average value of CP and FC, self-state* (independent variable), is performed. Simple regression analysis of creative behavior according to self-state* is performed, and multiple regression analysis of creative behavior according to self-state* and internal or external motivation is performed. Results In the results of this study, the personality traits of ‘critical parent(CP)’ and ‘free child(FC)’ show 25% explanatory power for internal motivation, 16% explanatory power for external motivation, and 43% explanatory power for creative behavior. The personality traits of CP and FC and internal motivation show 31% explanatory power for creative behavior. The personality traits of CP and FC and external motivation show 29% explanatory power for creative behavior. It is confirmed that each internal and external motive partially mediate the effect of the personality traits of FC and CP on creative behavior. Conclusions In order to cultivate the creative behavior of college students in Hunan Province's art design department and to develop each student's competitiveness and art design department, it is necessary to create an environment of school and society so that college students can create creative values in free discussion and freedom. It is necessary to stir up internal motivation that values pleasure and challenge rather than inducing external motivation that focuses on rewards.
A Thematic Analysis Study About the post COVID-19 new normal Based on the Experiences of Secondary School Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Byun You Kyoung , Park kyung Ae
Published: August 2022

Objectives This study was designed to explore the experiences of secondary school teachers who took preventive measures and did a job of teaching simultaneously in the COVID-19 situation, and to find out the post-new normal in terms of education presented by them. Methods The authors used the maximum variation sampling approach and selected eleven teachers as participants. The data was based on one-on-one in-depth interviews with the them. Data analysis was approached using the Thematic Analysis method suggested by Braun and Clarke (2006). Thematic analysis was conducted according to the six-step procedure suggested by the researchers, and sub-topics and themes were discovered. Results As a result of analyzing the research data, forty-five sub-themes were derived, and nine themes were conceived by reassembling them in the dimension of commonality in the meaning of commonality. The nine themes are: reconstruction of social cohesion through education, deep consideration for underprivileged students, establishment of school organic management system, substantive online education, safe and happy school, reorganization of horizontal decision-making structure, parents as educational cooperation partners, effective practices of the peers’ supervision and the dismantling of superficial education. Conclusions Although COVID-19 caused a crisis, it provided an opportunity for teachers to reflect on the nature of our education with disaster resilience.
The Effects of Flipped Learning Class Using Team-based Learning on Pre-service Early Childhood Teacher’s Achievement Motivation, Cooperative Self-efficacy, Cognitive Learning Competence, and Major Satisfaction
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jo Hyeyoung
Published: August 2022

Objectives The purpose of this study is to find out the effects of flipped learning class using team-based learning in early childhood music education class on the achievement motivation, cooperative self-efficacy, cognitive learning competence, and major satisfaction of pre-service early childhood teachers. Methods For this, using SPSS 23.0, we divided the research variables into pre- and post- and distributed the questionnaire to 45 students who took early childhood music education among K University's early childhood education department located in Chungcheongbuk-do. We confirmed the statistical significance in the 95% confidence interval by analyzing with the Paired T-test, which is a method of comparing the paired pre- and post-average data for each study variable. Results These are the main findings. First, the descriptive statistics for each variable, which were achievement motivation, cooperative self-efficacy, cognitive learning competence, and major satisfaction was higher than 3 points and satisfied the normality. In addition, the difference in average scores of research variables before and after flipped learning classes using team-based learning was found to have improved from a minimum of .11 to a maximum of .53. Second, the effects of flipped learning class using team-based learning on achievement motivation was not found to be statistically significant, whereas the effects on cooperative self-efficacy, cognitive learning competence, and major satisfaction were statistically significant. Conclusions The results of this study confirmed the possibility of applying the innovative teaching method as a practical study through the major satisfaction as well as the competence required for pre-service early childhood teachers. It is also meaningful in that it is used as basic data to suggest a direction to competence-based education.
Use of Herbal Products and Complementary and Alternative Medicine (CAM) During Pregnancy
Authors: KARGAR Aylar , KIZILTAN Gül
Published: August 2022

Ideal nutrition for all stages of pregnancy is so important, and the safety of consuming common foods, herbal products, complementary and alternative medicine (CAM), and nonnutritive substances is questionable. Despite the fact that herbs are entirely natural, not all of them are safe to ingest during pregnancy. Herbs such as ginger and peppermint are well known for being a powerful, safe, and effective remedy for vomiting and nausea during pregnancy. Pre-eclampsia and high blood pressure are among the important complications during pregnancy. Pre-eclampsia could be increased by drinking tea, while high blood pressure could be decreased with garlic consumption in pregnant women. During pregnancy blood glucose levels and glycogen storage are as important as blood pressure. Turmeric controls blood glucose levels, meanwhile red pepper enhances glycogen storage. Interacting with the cytochrome P450 system causes many food-drug interactions. St. John’s Wort is one of the commonly used herbs that affects this system and should be taken cautiously in pregnancy. Chamomile should be consumed cautiously as well due to its effects on individuals suffering from coagulation disorders. As a safe herb during breastfeeding, fennel should be consumed wisely in pregnancy. Fennel contains estrogen-like features that affect fetal development and birth weight. As herbal products have varying and ambiguous effects, they should be consumed (as condiments, flavoring in foods or beverages) prudently.
Dental Orta Hat Simetri-Asimetrisinin Dentofasiyal Estetik Algı Üzerine Etkisi
Authors: KOZAK Esin , TUNA Süleyman Hakan
Published: August 2022

Gülümseme sözsüz iletişimde etkili olup kişiye yönelik izlenimde önemli bir rol oynar. Estetik diş hekimliği uygulamalarında gülüş analizi tedavi yaklaşımının en önemli parçasıdır. Dental orta hat, iki santral kesici diş arasındaki temas yüzeyi olarak tanımlanır ayrıca anterior dişlerin konumlandırılmasında dikkate alınması gereken estetik faktörlerinden biridir. İdeal bir dental orta hat, dental kompozisyonda arzu edilen bir uyum ve birlik etkisini yaratır. Özellikle gülümseme simetrisinden söz edildiğinde, dental orta hat pozisyonunun önemi, dişsiz anterior bölgeyi restore ederken bir ön koşul oluşturmaktadır. Gülüş analizinde dental orta hat asimetri ve simetrisi özellikle değerlendirilmelidir. Bu çalışmadaki amacımız; gülüş simetrisinde rol oynayan dental orta hat asimetri ve simetrisinin fasiyal estetik algısı üzerindeki etkisini değerlendirmektir.
Pengaruh Konsentrasi Inhibitor dari Eceng Gondok dalam Air Hujan dan Air Kran terhadap Laju Korosi
Authors: Hermawati Emma , Sarungu Yunus Tonapa , Soeswanto Bambang , Rispiandi  , Adhitasari Alfiana , Abdulloh Sudrajat Harris , Sihombing Rony Pasonang , Indarti Retno
Published: August 2022

Organic inhibitors in the corrosion process could be obtained from water hyacinth plant. This plant contained antioxidants such as saponins, which could bind to protective metals from corrosion. The objective of this study was to observe the corrosion rate degradation in rainwater and tap water with saponin content of water hyacinth extract with novelty of using methanol in the maceration process. The sample: methanol ratio used in the maceration process was 1 : 9 (w/v). Steel testing was carried out for 5 days in rainwater and tap water. Based on the test results, the saponin content in the water hyacinth extract could be proven by the stability of the foam produced. The experimental results showed a corrosion rate escalation in tap water samples from 47.7% to 94.5% and samples in rainwater from 11.3% to 52.9% at 75 ppm inhibitor concentration. Based on the research, water hyacinth extract using methanol solvent could be used as a corrosion inhibitor.
Pengaruh Penyimpanan dan Lama Pemanasan Terhadap Kadar Asam Galat pada Kacang Tanah (Arachis hypogaea L.)
Authors: Dyah Wulandari Devyana , Nidianti Ersalina , Andini Ary , Fitri Awalia Rahmawati , Prisilia Halimah
Published: August 2022

One of the most prevalent phenolic acids to be found in foods such as fruits, vegetables, and herbal remedies is gallic acid, also known as 3,4,5-trihydroxybenzoic acid. The free acids, esters, catechin derivatives, and hydrolyzed tannins are the different ways that these substances are obtained. The specialty of this compound is due to its pharmacological activity as a radical scavenger. The total phenolic content in peanuts varies from 132.5 to 248.8 mg GAE/100 g. The purpose of this study was to determine the effect of storage time and heating time of peanuts (Arachis hypogaea L.) on gallic acid levels. Determination of gallic acid using the High Performance Liquid Chromatography (HPLC) method with the column used is an ODS (Octadesil Silica) C18 column and the mobile phase is a mixture of acetonitrile and aquadest (1:3). Peanuts were stored for 1 week, 2 weeks, and 3 weeks at 25°C and fried at 160°C for 2 minutes, 4 minutes, and 6 minutes. The results of this study on the length of storage obtained a P value of 0.000 where the results are smaller than 0.05. This indicates that storage time has a significant effect on gallic acid levels in peanut samples. Gallic acid levels appear to increase from the first week to the fourth week. Based on the results of the research at the time of heating obtained a P value of 0.189 where the results are higher than 0.05. This shows that the length of heating time does not affect on the gallic acid content in the peanut samples. From these results, it was concluded that gallic acid content was affected by storage time, but not by heating time.
Potensi Ekstrak Batang Kayu Gempol (Nauclea orientalis L.) dalam Menghambat Pertumbuhan Bakteri
Authors: Atmiyanti Ni Kadek , Satrimafitrah Pasjan , Razak Abd. Rahman , Inda Nov Irmawati , Indriani  , Puspitasari Dwi Juli
Published: August 2022

The study of the potential of Gempol wood stem extract (Nauclea orientalis L.) with three solvent polarities has been exercised to determine the extract with a certain polarity and the smallest concentration that can inhibit the growth of bacteria Staphylococcus aureus and Escherichia coil. Extraction is performed using the maceration method with n-hexane, ethyl acetate, and ethanol as solvents. Furthermore, the potency in inhibiting the growth of bacteria was observed by the diffusion method with a range of extract concentrations from the largest to the smallest. The extract's ability to inhibit bacterial growth in the time range of up to 24 hours was measured using the turbidimetric method. The results showed that ethyl acetate and ethanol extracts were able to inhibit the growth of both bacteria in a wide concentration range (100 %– 5%), although n-hexane extracts showed the highest percentage in inhibiting both bacteria (15.27 mm and 16.89 mm, respectively). Turbidimetric assays showed the extract was stronger in inhibiting S. aureus compared to E. coli in the logarithmic phase range of 12 hours. This study showed that semipolar and polar extracts can inhibit the growth of bacteria with a wider concentration range compared to non-polar extracts despite having a higher inhibition capability.
Associations of early and middle adulthood physical activity with symptoms of pelvic floor disorders in middle-aged women: an observational study with retrospective physical activity assessment
Authors: Kuutti Mari , Hyvärinen Matti , Kauppinen Markku , Sipilä Sarianna , Aukee Pauliina , Laakkonen Eija
Published: August 2022

Objective To investigate associations of early and middle
adulthood physical activity (PA) with symptoms of pelvic floor disorders
(PFD), i.e. stress urinary incontinence (SUI), urge urinary incontinence
(UUI), fecal incontinence (FI), constipation or defecation difficulties
(CDD), and feeling of pelvic organ prolapse (POP) among middle-aged
women.

Design A cross-sectional, observational study with
retrospective physical activity assessment.

Setting University Research Laboratory.

Sample A random population sample of 1098 47-to-55-year-old
Finnish women.

Methods PA history, current PA, and demographical and
gynaecological variables were assessed using self-report questionnaires.
Logistic regression analyses were applied to study associations of past
and current PA with PFDs. Associations of demographical and
gynaecological variables with PFDs were studied and their potential
confounding effect was controlled in multiple logistic regression
models.

Main outcome measures Structured questionnaire-assessed
retrospective physical activity history at the age of 17–29, current
physical activity at middle age, and prevalence of SUI, UUI, FI, CDD and
POP.

Results Current PA was not independently associated with the
occurrence of the PFDs. Middle-aged women with early adulthood history
of competitive sports were more likely to experience UUI (OR 2.161, 95%
CI 1.102–4.237, p=0.025) but not SUI, FI or POP, while women with
history of regular PA were more likely to experience FI (OR 4.405, 95%
CI 1.049–18.493, p=0.043) but not other PFDs.

Conclusions Competitive sports during early adulthood may
increase the risk of UUI at middle age. The history of regular PA may
increase the risk of FI. Keywords Pelvic floor function, exercise,
menopausal women
Dynamic analysis of New Two Dimensional Fractional-order Discrete Chaotic Map and Its application in Cryptosystem
Authors: Liu Zeyu , Xia Tiecheng , Hu Ye
Published: August 2022

A new fractional difference equation 2D-TFCDM based on Caputo derivative
is proposed. Using the bifurcation diagram, the maximum Lyapunov
exponent and the phase diagram, the numerical solutions of the
fractional difference equations are obtained, and the chaotic behavior
is observed numerically. After encrypting the key with elliptic curve
cryptosystem, the fractional map is developed as an encryption algorithm
and applied to color image encryption. Finally, the proposed encryption
system is systematically analyzed from five main aspects, and the
results show that the proposed encryption system has a good encryption
effect. In respective of application, we apply the proposed discrete
fractional map into color image encryption with the secret keys ciphered
by Menezes-Vanstone Elliptic Curve Cryptosystem (MVECC). Finally, the
image encryption algorithm is analysed in 4 aspects that indicates the
proposed algorithm is superior to others.
On umbral properties of a family of hyperbolic-like functions appearing in magnetic transport problem
Authors: Dattoli Giuseppe , Khan Subuhi , Haneef Mehnaz , Licciardi Silvia
Published: August 2022

The umbral operational techniques offer sturdy mechanism in the studies
of special functions and special polynomials. The techniques of the
umbral calculus are employed to derive the properties of families of
exponential like functions and their hyperbolic forms. The generalized
forms of Mittag-Leffler functions are used to solve the technical
problems concerning the transport of a charged beam in a solenoid
magnet. The proposed method is flexible and has many advantages over the
standard computational techniques.
Climate change effect on river runoff under CMIP6 GCM's in the Upper regions of Indus River
Authors: Haleem Kashif Haleem , Khan Afed Ullah , Khan Fayaz Ahmad , Zada Umar , Khan Jehanzeb
Published: August 2022

Pakistan is primarily dependent on water supplies from the Upper Indus
basin for irrigated agriculture. Any changes in available resources due
to climate, consequently has the potential to have a significant impact
on the environment. Coupled model inter-comparison project phase 6
(CMIP6) based global climate models (GCMs) under shared socioeconomic
pathways (SSP245) scenario were assessed to evaluate the study area for
climate change effect on river runoff using Soil and water assessment
tool (SWAT). Temperature fluctuations have a significant effect on
stream flow, since the primary sources of river runoff in the Upper
Regions of Indus Basin (URIB) are snow and glacier melting. The
temperature (min & max) will likely increase by almost 18% in the
future, the projected precipitation pattern will increase by 13-17 %,
and the stream flow will increase by 19-30 % in the future due to the
warmer temperature. Temperature (min & max), precipitation and stream
flow have had different effects in each season, while their variability
in the projected annual changes are increasing for mid and late 21
century. Hydroelectricity generation, irrigation,
flood prevention, and storage reservoir will be required in the
strategies and action plans for the effective water resources
management.
Water Area Variation and Response of River-lake Interactions in Poyang Lake from 1977 to 2021
Authors: Tian Biqing , Gao Peng , Mu Xingmin , Zhao Guangju
Published: August 2022

Lake has an essential role in Earth’s hydrologic cycle. The changing of
lake water areas shows the ecological health of lakes by instant
feedback. Remote sensing monitoring reflects the changes in lake water
intuitively. This study, based on remote sensing, combined with the
hydrological data, meteorological data, and land use survey,
investigated the Poyang lake water area changes from 1977 to 2021.
Examined the relationship between the lake water area and the impact
factor and analyzed the influence of river lake interaction on the lake
water area. The results showed that: (1) From 1977 to 2017, the water
area of Poyang Lake in flood season (June to September) and dry season
(November to Next February) showed a significant downward trend by
years. (2) In flood season, runoff, sediment, and precipitation
significantly correlate with a water area. In the dry season, sediment
significantly correlated with a water area. (3) The Three Gorges Dam
water impoundment at the upper reaches of the Yangtze River weakened and
eliminated the block and reverse flow of the Yangtze River on Poyang
lake, causing the water area to decrease in advance at the end of the
flood season after 2005, and decrease rapidly in the dry season after
2003. (4) The change in lakebed elevation caused by sedimentation and
human activities also accelerated the shrinkage of the water area.
Results demonstrated that the variation of river lake interaction is the
primary cause of the Poyang Lake water area’s dramatic change.
A systematic evaluation of quenching and extraction procedures for quantitative metabolome profiling of Hela carcinoma cell under 2D and 3D cell culture conditions
Authors: Wang Tong , Wang Xueting , Zhuang Yingping , Wang Guan
Published: August 2022

Metabolic reprogramming has been coined as a hallmark of cancer,
accompanied by which the alterations in metabolite levels have profound
effects on gene expression, cellular differentiation and the tumor
environment. Yet a systematic evaluation of quenching and extraction
procedures for quantitative metabolome profiling of tumor cells is
currently lacking. To achieve this, this study is aimed at establishing
an unbiased and leakage-free metabolome preparation protocol for Hela
carcinoma cell. We evaluated 12 combinations of quenching and extraction
methods from three quenchers (liquid nitrogen, -40°C 50% methanol,
0.5°C normal saline) and four extractants (80% methanol, methanol:
chloroform: water (1:1:1, v/v/v), 50% acetonitrile, 75°C 70% ethanol)
for global metabolite profiling of adherent Hela carcinoma cells. Based
on the isotope dilution mass spectrometry (IDMS) method, gas/liquid
chromatography in tandem with mass spectrometry was used to
quantitatively determine 43 metabolites including sugar phosphates,
organic acids, amino acids, adenosine nucleotides and coenzymes involved
in central carbon metabolism. Among 12 combinations, cells that washed
twice with phosphate buffered saline (PBS), quenched with liquid
nitrogen, and then extracted with 50% acetonitrile was found to be the
most optimal method to acquire intracellular metabolites with minimal
loss during sample preparation. Furthermore, a case study was carried
out to evaluate the effect of doxorubicin (DOX) on both adherent cells
and 3D tumor spheroids using quantitative metabolite profiling. Based on
this, quantitative time-resolved metabolite data can serve to the
generation of hypotheses on metabolic reprogramming to reveal its
important role in tumor development and treatment.
Optimal deployment of cultivated land quality monitoring points based on satellite-driven cultivated land quality and improved spatial simulated annealing
Authors: Liu Zhenhua , Yang Wenhao , Peng Yiping , Lin Chenjie , Yang Hao , Cheng Xinrong , Wu Xiaofang , Wen Ya
Published: August 2022

The deployment of scientific and reasonable cultivated land quality
(CLQ) monitoring points can provide timely and accurate information on
the current situation and changes in CLQ, which is highly important to
protect national food security. The conventional methods of selecting
CLQ monitoring points are based on the CLQ of land use patches. As there
may be different grades of large patches, being selected as monitoring
points reduces the reliability of monitoring CLQ. Moreover, the
conventional monitoring point deployment method mainly considers only
CLQ and ignores road accessibility and terrain as factors, resulting in
the inaccessibility of some monitoring points. Therefore, to improve the
reliability of CLQ monitoring, this study presented a novel approach for
deploying CLQ monitoring points. First, the pixel-scale CLQ was
estimated using the genetic algorithm-back propagation neural network
(GA-BPNN) model based on the Landstat8 data with 30 m spatial
resolution. Second, the stratified sampling model was used to determine
the optimal sample points. Finally, the improved spatial simulated
annealing algorithm (ISSA), considering both slope and road
accessibility, was applied to optimize the location of monitoring
points. This study was conducted in the Conghua District of Guangzhou,
Guangdong Province, China. The results highlighted that (1) compared to
the accuracy of measured CLQ, the accuracy (R 0.63, RMSE = 79.32, and
NRMSE = 13.77%) of CLQ estimated using the remote sensing technique was
reliable, and the pixel-scale CLQ data was more reasonable than the
patch-scale CLQ data with different grades. (2) A total of 132
monitoring points were finally identified in the study area based on the
stratified sampling model. (3) When compared with those of the spatial
simulated annealing algorithm (SSA) and the standard grid method, the
approach proposed in this study had a higher total score (F = 94.61).
Moreover, the obtained sample points were mainly located near roads and
flat terrain. This can effectively avoid the inaccessible places. Thus,
the results based on the novel approach proposed in this study provide a
scientific basis and technical support for obtaining the optimal CLQ
monitoring points.
Comparative Effectiveness and Safety of Direct Oral Anticoagulants versus Warfarin in Patients with Atrial Fibrillation and Stage III Chronic Kidney Disease
Authors: Perreault Sylvie , Boivin-Proulx Laurie-Anne , Lenglet Aurélie , Massy Ziad , Dorais Marc
Published: August 2022

Aim: The effectiveness and safety of direct oral anticoagulants (DOACs)
in atrial fibrillation (AF) patients with stage III chronic kidney
disease (CKD) are still subject to debate. We therefore assessed and
compared the effectiveness and safety of DOACs vs. warfarin in this
population. Methods: A cohort of patients with an inpatient or
outpatient code for AF and stage III CKD who were newly prescribed an
oral anticoagulant (OAC) was created using administrative databases from
the Quebec province of Canada between 2013 and 2017. The primary
effectiveness outcome was a composite of ischemic stroke, systemic
embolism, and death, whereas the primary safety outcome was a composite
of major bleeding within a year of DOAC vs. warfarin initiation.
Treatment groups were compared in an on-treatment analysis using inverse
probability of treatment weighting and Cox proportional hazards.
Results. A total of 8,899 included patients filled a new OAC claim:
3,335 for warfarin and 5,564 DOACs. Compared with warfarin, rivaroxaban
15 mg and 20 mg presented a similar effectiveness and safety composite
risk. Apixaban 5.0 mg was associated with a lower effectiveness
composite risk (Hazard ratio [HR] 0.76; 95% confidence interval
[CI] 0.65–0.88) and a similar safety risk (HR 0.94; 95% CI
0.66–1.35), whereas apixaban 2.5 mg was associated with a similar
effectiveness composite (HR 1.00; 95% CI 0.79–1.26) and a lower safety
risk (HR 0.65; 95% CI 0.43–0.99). Conclusion: In comparison with
warfarin, rivaroxaban and apixaban appear to be effective and safe in AF
patients with stage III CKD.
Design of a New Modular Reconfigurable Gripper
Authors: ahmed Ahmad khalid , Ahmed Ahmed Khalid , Ezdeen Safeen Yaseen , Sinjari Ahmad Mohamad
Published: August 2022

An entirely new reconfigurable gripper is designed and shown in this paper. The new gripper comprises six modular fingers, which can be rearranged to form any number of fingers between three and six. CAD, CAM, CAE, and PCB software Fusion 360 was used to design the gripper. Also, the gripper fingers are rotatable, so the finger bases can touch each other side-by-side and form one finger. In addition to showing the reconfigurability of the gripper, several scenarios for grasping different shapes were presented and tested.
A tale about an unusual cause of pygalgia in ankylosing spondyloarthritis
Authors: Dhahri Rim , Bettaieb Hiba , SLOUMA Maroua , Khrifech Yasmine , Mallat youssef , Amri Khalil , Harbaoui Ahmed , Metoui Leila , Gharsallah Imen , Louzir Bassem
Published: August 2022

Neurinomas are tumors of Schwann cells of the peripheral nerve sheath.
Sacral location is rarely reported especially in spondyloarthritis
patients. Herein, we report a case of uncommon pygalgia in a 25-year-old
man with history of a non-radiographic axial spondyloarthritis and in
whom the diagnosis of sacral neurinoma was established.
The Outbreak Of Human Monkeypox Amidst Covid-19 Delta Variant: Suspicion Of A Possible Case In Pakistan?
Authors: Rehman Ibad ur , iqbal Dr Khadija , khan Ubaid , Ullah Irfan
Published: August 2022

The Human Monkeypox virus belongs to the Poxvirdiae family of the
Orthopoxvirus genus. This virus is seen to get transmitted to humans
predominantly by contact transmission via infected animals and humans.
It exhibits a range of clinical features apart from the common rash,
swollen lymph nodes, and flu-like symptoms.
Comparison of the Korean Activity Status Index with cardiopulmonary exercise test in patients with acute myocardial infarction
Authors: Kim Youn Ji , Choi Jun Hwan , Kim Bo Ryun , Lee So Young , Lee Hyun Jung , Kim Song-Yi , Lee Jae-Geun
Published: August 2022

This study aimed to compare the Korean Activity Status Index (KASI) with the cardiopulmonary exercise test (CPET) among patients with acute myocardial infarction. A total of 2,268 patients (85.4% male; mean age, 59.3±10.2 years; range, 23-90 years) diagnosed with acute myocardial infarction were enrolled in the Regional Center Myocardial Infarction Registry between July 2016 and June 2019. The KASI is a tool used to measure functional capacity by asking patients about their ability to perform specific activities and then scoring their responses. In contrast, CPET is the gold standard for assessing the objective functional capacity in patients undergoing cardiac rehabilitation. Peak oxygen uptake (VO2peak) was used to analyze the correlation. Patients who completed two consecutive KASI and CPET evaluations during their first (KASI_1, VO2peak_1) and second visits (KASI_2, VO2peak_2) for cardiac rehabilitation were included in the study. The mean KASI_1 and KASI_2 scores were 43.3±14.3 and 49.8±13.9, respectively, and the mean VO2peak_1 and VO2peak_2 scores were 25.9±8.0 and 28.5±8.3, respectively. Both the KASI scores were significantly correlated with the measured VO2peak during each visit, with correlation coefficients of 0.385 (P<0.001) and 0.346 (P<0.001), respectively. Moreover, the KASI score and VO2peak had a linear relationship (VO2peak_1=0.22×KASI_1+16.5, P<0.001; VO2peak_2=0.21×KASI_2+18.2, P<0.001). This study revealed that the KASI is a valid measure for the follow-up evaluation of the functional capacity of patients. These findings suggest that VO2peak can be predicted using the KASI score in patients who do not undergo CPET.
Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes
Authors: Crawford Samantha A. , Wiles Timothy A. , Wenzlau Janet M. , Powell Roger L. , Barbour Gene , Dang Mylinh , Groegler Jason , Barra Jessie M. , Burnette KaLia S. , Hohenstein Anita C. , Baker Rocky L. , Tse Hubert M. , Haskins Kathryn , Delong Thomas
Published: August 2022

Hybrid insulin peptides (HIPs) form in pancreatic β-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs have been identified in pancreatic islets by mass spectrometry and are targeted by CD4 T cells in patients with type 1 diabetes (T1D) as well as by pathogenic CD4 T-cell clones in nonobese diabetic (NOD) mice. The mechanism of HIP formation is currently poorly understood; however, it is well established that proteases can drive the formation of new peptide bonds in a side reaction during peptide bond hydrolysis. Here, we used a proteomic strategy on enriched insulin granules and identified cathepsin D (CatD) as the primary protease driving the specific formation of HIPs targeted by disease-relevant CD4 T cells in T1D. We also established that NOD islets deficient in cathepsin L (CatL), another protease implicated in the formation of disease-relevant HIPs, contain elevated levels of HIPs, indicating a role for CatL in the proteolytic degradation of HIPs. In summary, our data suggest that CatD may be a therapeutic target in efforts to prevent or slow the autoimmune destruction of β-cells mediated by HIP-reactive CD4 T cells in T1D.
Cathepsin D drives the formation of hybrid insulin peptides relevant to the pathogenesis of type 1 diabetes
Authors: Crawford Samantha A. , Wiles Timothy A. , Wenzlau Janet M. , Powell Roger L. , Barbour Gene , Dang Mylinh , Groegler Jason , Barra Jessie M. , Burnette KaLia S. , Hohenstein Anita C. , Baker Rocky L. , Tse Hubert M. , Haskins Kathryn , Delong Thomas
Published: August 2022

Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs have been identified in pancreatic islets by mass spectrometry and are targeted by CD4 T cells in patients with Type 1 Diabetes (T1D), as well as by pathogenic CD4 T cell clones in non-obese diabetic (NOD) mice. The mechanism of HIP formation is currently poorly understood; however, it is well established that proteases can drive the formation of new peptide bonds in a side reaction during peptide bond hydrolysis. Here, we used a proteomic strategy on enriched insulin granules and identified cathepsin D (CatD) as the primary protease driving the specific formation of HIPs targeted by disease-relevant CD4 T cells in T1D. We also established that NOD islets deficient in cathepsin L (CatL), another protease implicated in the formation of disease-relevant HIPs, contain elevated levels of HIPs, indicating a role for CatL in the proteolytic degradation of HIPs. In summary, our data suggest that CatD may be a therapeutic target in efforts to prevent or slow down the autoimmune destruction of beta-cells mediated by HIP-reactive CD4 T cells in T1D. 