bluuebunny/crossref_metadata_2025 huggingface dataset:
SAH and C. elegans Longevity: Insights from an AHCY Deficiency Model
Authors: Pokrzywa Wojciech , Thapa Pankaj , Banasiak Katarzyna , Serwa Remigiusz
Published: April 2023

Supplementation with S-adenosylhomocysteine (SAH) extends the lifespan of model organisms. To explore the impact of SAH on aging, we generated a Caenorhabditis elegans model with increased SAH levels through pathogenic mutation in the S-adenosylhomocysteine hydrolase (AHCY), which impairs SAH hydrolysis to adenosine and homocysteine. We showed that animals with an endogenous mutation leading to pathogenic AHCY Y145C exhibited delayed aging accompanied by increased SAH and reduced SAM levels. The extended longevity of these animals required AMP-activated protein kinase (AMPK). Our results demonstrate the potential of AHCY mutant worms as a tool to study SAH influence on aging and point to the SAM:SAH ratio as a potential determinant of C. elegans lifespan.
Dimensions of women’s mobility, livelihoods, and vulnerability in artisanal and small-scale mining-induced local economy
Authors: Arthur-Holmes Francis , Yeboah Thomas , Busia Kwaku Abrefa
Published: April 2023

Dominant artisanal and small-scale mining (ASM) narratives highlight the invisibility of women’s livelihoods and gendered struggles in the sector. Indeed, the dimensions of women’s livelihoods in ASM, how daily mobilities aid this, and the specific vulnerabilities various women face in ASM settings are still understudied and undertheorised. Drawing on a local economy perspective and qualitative research involving semi-structured interviews and field observations in Ghana, we explore the livelihood dimensions of different women engaged in ASM within the context of an open rural economy. Our findings highlight diverse groups of women building livelihoods in ASM: young girls and women during school holidays, young junior high school students and apprentices working during weekends, young girls awaiting their Basic Education Certificate Examination results, young women in need of money for learning a vocation, pregnant teens/young women, and women in pursuit of money to set up micro enterprises (petty-trading) build a temporary livelihood in ASM to deal with their dire economic situations. However, destitute women, single, divorced/separated, married women, migrants, and widows who face economic hardships, as well as those who struggle to have better alternative livelihood options in the rural economy, choose to create a permanent source of income from ASM through their participation as diggers, selectors, or carriers of ore. The third livelihood dimension is the indirect livelihood opportunities ASM offer to women through 'san ban ho’ (side-work livelihood based on credit conditions); petty-trading in ASM spaces; home-based trading; and market-day trading; commuting trading; underground pit ‘ghetto’ sponsorship. While daily mobility shapes the viability of livelihood-building efforts in ASM, in most cases, women experience different health and economic vulnerabilities that affect their health-related quality of life and livelihood gains. Some of these vulnerabilities include sexual exploitation and teenage pregnancies among young women and girls of school-going age, and economic hardships caused by the state-imposed ban on ASM on the livelihood of women such as ‘san ban ho’ and commuting traders who indirectly depend on the boom in ASM communities. We argue that formalisation efforts and policies ought to advance employment opportunities for women who directly and indirectly participate in the ASM sector without displacing them and destroying the livelihoods of women whose income, daily survival and very existence are dependent on ASM.
Influence of Benevolence and Credibility on Conduct of Integrative Negotiation Behaviours
Authors: Rahmoune Mbarek , Alsagaf Mohamed , Abdeltawab Ahmad Mostafa , Azhari Abdullah , Hofaidhllaoui Mahrane
Published: April 2023

This paper aims to determine the influence of benevolence and credibility on cooperative negotiation in the B2B markets between manufacturers and distributors using the dyadic methodology. The Principal Component Analysis (PCA) emphasizes the bi-dimensionality of trust, credibility, and benevolence by surveying 253 manufacturers and 53 distributors. Analyzing the perceptions of Producers and Retailers revealed the existence of a “perceptual convergence” between them. Moreover, the results from the dyadic analysis of the representative sample of the study showed a significant and positive impact of credibility on integrative and cooperative negotiation behavior. However, it also revealed an insignificant relation between cause and effect between benevolence and integrative and cooperative negotiation behavior. After using regression, benevolence as a dimension of trust positively impacts the integrative and cooperative negotiation behavior estimates reject. This research created a retailer and manufacturer integrative and cooperative negotiation behavior model for the B2B markets, adding to the greater knowledge of Marketing and Management. The proposed model shall aid manufacturers and retailers in effective integrative business negotiation. Retailers, who are more powerful than producers, benefit more from utilizing negotiation as a tool to exercise a better influence over producers/suppliers and, thus, reach better results. Nevertheless, the findings revealed that Trust impacts positively and directly integrative negotiation. Hence, it suggests building integrative and cooperative negotiations between producers and retailers depending on the degree of trust between them. Finally, the findings can be considered an evident aid for managers to accomplish effective negotiations better. It is worth mentioning that the results of the PCA of producers’ and retailers’ perceptions designate the insignificant relationship between benevolence and integrative negotiation.
Contribution to Industrial Buyer Behavior Model: An Empirical Research
Authors: Aydin Sedat , Ungan Mustafa Cahit
Published: April 2023

Today’s businesses experience many uncertainties in their internal operations and environments. Manufacturing flexibility is an excellent response to these uncertainties. Volume, modification, mix, and expansion flexibilities are the manufacturing flexibilities that businesses look for when they select their suppliers. In parallel, these flexibilities are often used as a supplier selection criterion in the literature. The supplier selection decision is a strategic issue for today’s businesses as a typical company is highly dependent on its suppliers to procure raw materials and parts. Sound supplier selection decision leads to competitive advantage because it is related to a positive relationship between buyer and supplier and reciprocal improvement of performance and trust between both parties. However, a literature review for this study showed a need for more empirical work on the relationship among types of flexibilities, supplier selection, performance improvement, long-term relationships, and trust. In order to fill the gap in this area, data was collected from 148 automotive companies operating in Turkey. For the data collection, the automotive industry was chosen as it is subjected to more uncertainties due to its connections to many other industries. The data were then analyzed using the structural equation model. The results showed a significant positive relationship between types of manufacturing flexibility and supplier selection. Also, positive relationships were found among supplier selection, performance, long-term relationships, and trust. Mediation and indirect effect analysis were also conducted. Long-term relationships and performance fully mediated the relationship between supplier selection and trust. An indirect relationship between supplier selection and trust was also found. The study results are expected to contribute to Sheth’s buyer-behavior model by introducing manufacturing flexibility, long-term relationship, performance, and trust to the model. Also, the study’s findings assist executives in making more informed decisions concerning supplier selection, depending on the level and types of flexibility they demand from their suppliers, performance, long-term relationships, and trust.
The effect of SME leadership style on employee turnover intention through employee engagement Focusing on transformational, empowering and authentic leadership
Authors:   Human Engagement Institute, Sul WoongHwan , Jo Hyunjeong , Kim Woocheol
Published: April 2023

Human resource development of a company is a factor for the sustainable survival of a company and is recognized as an important source that determines the success or failure of the company. However, most SMEs are experiencing negative consequences from the departure of organizational members, which causes difficulty in human resource development for SMEs.
Therefore it is necessary to identify the variables that affect the turnover intention of SME workers. In this study 321 data were analyzed through convenience sampling for SME organizational members, and the following research results were derived by confirming the structural relationship between variables of transformational, empowering, authentic leadership, employee commitment, and turnover intention. First it was found that transformational, empowering, and authentic leadership did not directly affect turnover intention. Second, it was found that employee engagement showed a positive (+) relationship with transformational, empowering, and authentic leadership, a negative (-) relationship with turnover intention, and mediated the relationship between leadership and turnover intention. Third, among the models explaining the relationship between each leadership, employee commitment, and turnover intention, the research model of transformational leadership, employee commitment, and turnover intention was found to be the most effective in increasing employee commitment and lowering turnover intention. This study is an empirical study comparing how transformational, empowering, and authentic leadership affect employee engagement and turnover intention of SME organizational members, and what the actual utility of leadership through employee engagement is by leadership type. Based on the above findings, academic and practical implications are presented.
The effects of SMEs employees’ learning support environment on innovative work behavior : Focusing on the mediating roles of self-efficacy and Eemployee engagement
Authors:   Human Engagement Institute, Lee Seungyul , Park Jiwon
Published: April 2023

The purpose of this study is to recognize the importance of innovative work behavior and learning support environment for organizations to survive and be competitive in a rapidly changing business environment, and to identify the factors and environments in which members can actively realize innovative behavior. The learning support environment was treated as an independent variable, self-efficacy and employee engagement were considered as mediating factors affects innovative work behavior, and HRD academic and practical implications are presented through understanding of the process in which innovative work behavior is induced. To this end, an online survey was conducted on 400 workers who have worked at SMEs with less than 300 employees for more than a year, and the structural relationship between variables was analyzed using structural equation modeling. The results of the study show that the learning support environment had a positive (+) effect on all of innovative work behavior, self-efficacy, and employee engagement, and self-efficacy had a positive (+) effect on employee engagement and innovative work behavior. In addition, both self-efficacy and employee engagement had a significant mediating effect between the learning support environment and innovative work behavior, and the dual mediating effect between self-efficacy and employee engagement was also statistically significan
Exploring the expertise development process of assessors in government-supported vocational training
Authors:   Human Engagement Institute, Lee Sang-Gil , Ryu Ki-Ung
Published: April 2023

The purpose of this study was to understand the expertise development process of assessors of government-supported vocational training. Nine research participants were selected through theoretical sampling, and data were collected through in-depth interviews. Based on the collected data, phenomenon understanding analysis, category relationship analysis and theoretical integration analysis were conducted step by step using the systematic grounded theory. In the phenomenon understanding analysis, a number of concepts and 15 categories were extracted. In the category relationship analysis, the categories were first reconstructed based on a specific framework, and the relationship between the categories was identified through causal relation analysis, procedural relation analysis, and micro-macroscopic relation analysis. In the theoretical integration analysis, ‘the applying oneself and studying hard to cultivate expertise’, a key category, was derived, and a theory about the expertise development process of government-supported vocational training assessors was presented as a model. The expertise development process of the research participants continued to evolve through the process of leading self-development and self-reflection in various interactive experiences occurring in the evaluation field. In addition, it was confirmed that they were able to build an effective system as an evaluator and improve their ability to respond flexibly to various unexpected situations that occur in the dynamic evaluation field.
The effects of oxygen fugacity and sulfur on the pressure of vapor-saturation of magma
Authors: Hughes Ery C. , Liggins Philippa , Saper Lee , Stolper Edward M.
Published: April 2023

Geobarometers are commonly used to determine the pressure (and hence depth) of magmatic bodies. For instance, at equilibrium, the concentration of dissolved volatiles in a vapor-saturated melt can be used as a barometer: this is the pressure of vapor-saturation (Psatv). Most determinations of Psatv assume that melt and vapor contain only oxidized C-O-H species. However, sulfur is the third most abundant volatile element in magmas, and oxygen fugacity (fO2) exerts a strong influence on the speciation of the melt and vapor. To explore how S and fO2 affect calculations of Psatv, we model a Hawaiian tholeiite that contains both reduced and oxidized C-O-H-S species in the melt and vapor. We find that excluding reduced C-O-H species in the system can result in significant underestimations of Psatv under reducing conditions (ΔFMQ < 0). The effect of S on Psatv is small except in the vicinity of the “sulfur solubility minimum” (SSmin; 0 < ΔFMQ < +2), where excluding S-bearing species can result in underestimates of Psatv.

The implications of these results depend on the volatile concentration of the system being investigated, its fO2, and the melt composition and temperature. Our results suggest there will be little impact on Psatv calculated for mid-ocean ridge basalts because their fO2 is above where reduced C-O-H species become important in the melt and vapor and yet below the SSmin. However, the fO2 of ocean island and arc basalts are close enough to the SSmin and their S concentrations high enough to influence Psatv. However, high-CO2 and high-H2O concentrations are predicted to reduce the effect of the SSmin. Hence, Psatv calculated for shallowly trapped melt inclusions and matrix glass are more affected by the SSmin than deeply trapped melt inclusions. Lunar and martian magmas are typically more reduced than terrestrial magmas, and therefore accurate Psatv calculations for them require the inclusion of reduced C-O-H species.
Integrable Floquet systems related to logarithmic conformal field theory
Authors: Yashin Vsevolod I. , Kurlov Denis V. , Fedorov Aleksey K. , Gritsev Vladimir
Published: April 2023

We study an integrable Floquet quantum system related to lattice statistical systems in the universality class of dense polymers. These systems are described by a particular non-unitary representation of the Temperley-Lieb algebra. We find a simple Lie algebra structure for the elements of Temperley-Lieb algebra which are invariant under shift by two lattice sites, and show how the local Floquet conserved charges and the Floquet Hamiltonian are expressed in terms of this algebra. The system has a phase transition between local and non-local phases of the Floquet Hamiltonian. We provide a strong indication that in the scaling limit this non-equilibrium system is described by the logarithmic conformal field theory.
In vitro conservation of mangaba (Hancornia speciosa Gomes): An important fruit tree of Brazilian Cerrado
Authors: Pires Danyela Cristina Marques , Asmar Simone Abreu , Luz José Magno Queiroz , Pasqual Moacir , Rezende Renata Alves Lara Silva , Dória Joyce
Published: April 2023

This study aimed at evaluating the effect of osmotic agents, sucrose, and abscisic acid on the in vitro conservation of mangaba trees by slow growth. Two experiments were carried out. Nodal segments were inoculated in the MS medium with the addition of 1) osmotic agents (15, 20, and 25 g L-1 of mannitol and 10, 20, and 40 g L-1 of sorbitol) + control; 2) sucrose (0, 10, 20 and 30 g L-1) and abscisic acid – ABA (0 and 0.5 mg L-1). After carrying out the experiments, both were performed again, this time with the addition of 2 g L-1 activated charcoal to the medium for comparison. The survival rate and number of green leaves were evaluated after 45 and 90 days. For growth recovery, the explants were transferred to a specific growth medium, consisting of MS medium supplemented with 7 g L-1 agar, 1 mg L-1 6-benzylaminopurine (BAP), 1 mg L-1 1-naphthaleneacetic acid (NAA), 2 g L-1 activated charcoal. At 60 days, survival rate, number of green leaves, number of nodes, shoot length and fresh weight of the explants were assessed. The results showed that the use of 2 g L-1 of activated charcoal improves the growth and development of the explants. The tested doses of osmotic agents also did not influence the evaluated characteristics. However, there was significant effect of osmotic agent and time on survival rate and treatment x time interaction for the number of green leaves, having been influenced also by the use of osmotic agent at 45 days, in addition to significant differences between the control and the other treatments for this characteristic. The osmotic agents were not effective in plant conservation as well as the use of ABA. According to the conditions of this study, it is recommended the use of 30 g L-1 sucrose to the culture medium for up to 90 days in a row of in vitro conservation of mangaba plants.
Adolescentes escolares, sexualidade e a utilização do círculo de cultura de Paulo Freire
Authors: De Souza Davi Rodrigues , Ximenes Neto Francisco Rosemiro Guimarães , Cavalcante João Henrique Vasconcelos
Published: April 2023

O estudo teve por objetivo identificar as práticas e vivências da sexualidade de adolescentes escolares, por meio da utilização do Círculo de Cultura. Trata-se de uma pesquisa-intervenção, desenvolvida com 15 adolescentes de uma escola estadual de ensino médio de Forquilha, Ceará, Brasil, na qual foram realizadas ações educativas seguindo as etapas propostas no Círculo de Cultura, de Paulo Freire. A busca por conhecer os aspectos relacionados à sexualidade dos adolescentes proporcionou um exercício de autoconhecimento e autoconceito para os participantes, revelando aspectos de seu cotidiano, como os conflitos geracionais e as vivências da sexualidade, numa perspectiva contemporânea. O uso do Círculo de Cultura instigou o protagonismo, visto que os adolescentes discutiram temas polêmicos e relevantes, e ainda mediaram o conhecimento entre seus pares.
Urbanization effects on the groundwater potential recharge of the aquifers in the southern part of the Basin of Mexico
Authors: Ávila-Carrasco José Roberto , Hernández-Hernández Mario Alberto , Herrera Graciela S. , Hernández-García Guillermo De Jesús
Published: April 2023

Collection, processing, and analysis of GIS and satellite data were performed in this work to estimate temporal groundwater recharge changes, which are needed as input in numerical groundwater-flow models. Layers of geological alignments, land use, drainage network, lithology, topography, and precipitation were collected. This information was spatialized, then layer importance was calculated using an Analytic Hierarchy Process (AHP) based on infiltration capacity to define Potential Recharge (PR) regions. A water budget equation was used to calculate PR volumes. The analysis was done every five years from 1970-19, considering average urban area changes. For all study periods, an increase in urban area was calculated from 16 to 28% of the total study area, while potential recharge decreased from 23 to 19% of the mean precipitation values for each 5-year period. The most significant urban expansion was from 1980-94 and 2010-19, which match periods of potential recharge decrease. However, a slight increase in PR from 2000-09, unrelated to urban area change, may be due to temperature variations. The results account for the spatial and temporal dynamics of the recharge in the study area and can be used as input data to calibrate the actual recharge in a groundwater numerical model.
A Research on Oral Formulas(口訣 kugyŏl)in Sŏjon Taemun (書傳大文) Printed with Ŭlhae Type Housed in Hwasan Collection at Korea University
Authors:   The Association of DaeDong-Hanmun, Noh Johann
Published: April 2023

In the Hwasan collection at the Korea University Library, a rare book named Sŏjon Taemun(書傳大文) is preserved. It is easy to think of this book that it was printed during King Chongjo's reign as its title includes the term ‘Taemun’(大文) which means the original text of the Classics, but this book was edited and printed in the early Chosŏn period with kugyŏl for its original text of the Shujing. Furthermore, how does the oral formulas of the book relate to the oral formulas and translations of Sŏjon onhae, and what position does it occupy in the flow of the interpretation of the Classics in the early Chosŏn period? With these points in mind, this paper discusses Sŏjon Taemun.
Relationship and Poetry of Geomseogwan,Neungyang Park Jongseon
Authors:   The Association of DaeDong-Hanmun, Son Hye-ri
Published: April 2023

This article focuses on social relationship of Neungyang(菱洋) Park Jongseon(朴宗善, 1759~1819) and poems written for relation, when he was geomseogwan(檢書官) in Kyujanggak(奎章閣). Park served as geomseogwan twice, under Jeongjo(正祖) and Soonjo(純祖), and greatly influenced by the first four geomseogwans. Thus in 1806(Soonjo 6), he wrote ‘Samae-si(三哀詩)’ for previous geomseogwan Lee Dukmoo(李德懋), Park Jega(朴齊家), and Seo Isoo(徐理修) who passed away. In most of his poems he put annotations, and in ‘Samae-si’ Park put annotation to almost every line, which helps his intention delivered correctly. Also in ‘Jicjoong-japyong(直中雜詠)’ he left valuable information about Soonjo- era geomseogwans such as Park Jongsan(朴宗山), Lee Uksoo(李旭秀), Lee Gwangkyoo(李光葵), Kim Sahyon(金思玄), Yoo Bonye(柳本藝).
Through this research it is clear that Park Jongseon embodied poetics based on erudite studies shared with relationship during his service as geomseogwan. Also from this article Park’s poetic ability is affirmed and useful information about geomseogwans of late 18th century to early 19th century is attained, which would guide following researches on poet Park Jongseon or Late Choson Seo-ul Literature.
Consideration on Jolsujae Cho Tae-jing’s Defenseof the Master
Authors:   The Association of DaeDong-Hanmun, Jung Man-ho
Published: April 2023

Jolsujae (拙修齋) Cho Tae-jing was a respected figure who studied under Myungjae Yoon Jeung pursuing sincere learning and devout practice. Both his poems and Mansi (挽詩) and ritual texts written by his acquaintances to express condolences after his death were published as 『Jolsujaejip』 consisting of six volumes and three books. Later generations evaluated Jolsujae as a person who strived for virtuous deeds rather than writing. like the evaluation, the poems he left are plain, instructive, and sincere instead of being literature full of splendid rhetoric or unique ideas. From the perspective of literature, it is difficult to say that he made noteworthy achievements in his works in terms of the quantity and quality, but  contained in Volume 3 seems remarkable in the aspects of Cho Tae-jing’s own devotion to the master (師門; Samun), the full account of destructing 『Rhoseoyugo』, and the logic of responding to Hoenisibi (懷尼是非). Since Cho Tae-jing has not been noted in the academic world, this paper first introduces his life and studies, considers the full story of Samun Byeonmu (師門 辨誣 ), and then examines the significance of Jolsujae’s petition.
Hoenisibi ended officially in 1716 through King Sukjong’s Disposition of Byeongsin (丙申處分). Pointing out the deeds of Yun Seon-geo including the father and son’s and the problems of 『Rhoseoyugo』, Shin Gu filed a petition, which led to the Disposition of Byeongsin after all. When Oh Myeong-jun (吳命峻), Eom Gyeong-su (嚴慶遂), and Lee Hong-je (李弘濟) supported Shin-gu’s raising of the issue, King Sukjong defined his position to agree with Oh Myung-jun and so on. Later, when Kim Chang-jip (金昌集) raised an objection again, King Sukjong changed his position and ordered them to destroy 『Rhoseoyugo』. Accordingly, Cho Tae-jing wrote a petition with his Samun to defend them; however, it was not delivered to King Sukjong, and Cho Tae-jing was imprisoned in Uigeumbu instead. Cho Tae-jing who failed to make a defense passed away the following year, and the resentment of his failure was included not only in his poems but in the writings of his acquaintances, too.
Cho Tae-jing’s logic of defense is similar to that of those who defended Yoon Seon-geo and the father and son. However, he made more precise logic by securing richer evidence. His logic was not only influenced by the arguments of the predecessors but had influence over the advocacy of the latter generations for Samun. One evidence is that Yun Gwang-so (尹光紹) quoted Cho Tae-jing’s phrases just as they were in his petition. Meanwhile, Cho Tae-jing argued that those who attacked Yoon Seon-geo and the father and son ignored the overall context of the article and drew up the report by selecting only the sentences they needed. However, he showed that limitation, too, as he used the same means.
Process of Formulating Pildam and Its Characteristics: 『Chusa Pildam-cheop』 and ｢Banhyeongchonghwa｣
Authors:   The Association of DaeDong-Hanmun, Choi Sik
Published: April 2023

The process of formulating Pildam (conversation in writing) to the present time is focused on the comparative review of contents of Park Je-ga related 『Chusa Pildam-cheop 2』 with 『Yeolha Gihaengsiju·『Yeondae Jaeyurok』·『Hojeojip』and others to record the damcho (writing for a recorded story) to be collected and rearranged, and it inspected the process of addition, edition and revision thereafter. In addition, diverse characteristics and features of pildam have been observed with the subject of ｢Banhyeongchonghwa｣ with the theme of 『Susarok』 of Han Pil-gyo.
The Park Je-ga related pildam of 『Chusa Pildam-cheop』 contains only the pertinent contents of 『Yeolha Gihaengsiju』 and 『Yeondae Jayurok』of Yoo Deuk-gong and 『Hojeojip』of Park Jang-am, but it was actually omitted. It is actually excluded in the process of Park Je-ga and Yoo Deuk-gong collecting and rearranging the damcho that had the pildam with the Chinese intellectuals. Therefore, the damcho at the time of yeonhaeng (journey in visiting China) to be recorded in 『Chusa Pildam-cheop 2』, and it was added and edited to be revised in 『Yeolha Gihaengsiju』, 『Yeondae Jaeyurok』, 『Hojeojip』 and the like.
｢Banhyeongchonghwa｣ records the fact of meeting various people ranging from the Tamlla stranded person met at Yagyeta to Chinese intellectuals, such as, Han Woon-hae, Lee Jang-wook, Yoo Hee-hae and others who were exchanged in Beijing as well as Go Guk-rye of Aklasagwan (private photo shop operated by Russian) to share the conversation or Pildam as well as the fact of exchanging Chinese poetry and letters. Accordingly, it depicts the cases by capturing the situation of Chinese intellectuals attempting to refrain from contacting the envoys from Joseon Dynasty, and having someone to act on pildam when the pildam was exchanged by encountering of Manchurian and foreigner. It even displays all kinds of humiliations in the process of collecting the damcho, or wasting the time and effort from encountering deception of an old man who acted as Seosomun at Muryeong-hyeon. In a word, ｢Banhyeongchonghwa｣ is the data that demonstrates the diverse characteristics and features of Pildam.
A Study on Lyeohanshibgamuncho
Authors:   The Association of DaeDong-Hanmun, Yuan Cheng , Zhang Xu
Published: April 2023

At the early years of the 20th century, Lyeohanshibgamuncho was published twice at Nantong Hanmolin bookstore in China. It was Wang Seongsun who completed the compiling of Lyeohanshibgamuncho, instead of Kim Taeyeong. At the beginning, Muncho was edited by Kim Taeyeong. After three editions, 9 Korean litterateurs' works were picked up into a book, called Lyeohanmunseon or Lyeohangugamuncho. Afterwards, Wang Seongsun made Kim the 10th person and re-selected the works. Compared with Kim's Lyeohangugamuncho, the works selected by Wang were totally different. However, Kim and Wang followed the same principle when selecting.
The birth of Muncho was closely bound up with historical background. Under the extremely serious national crisis, the Korean patriots, like Kim and Wang, realized the importance of national culture. They restated the history of Korean and promoted the literature of Korean. In that way, they tried to save the nation from subjugation and ensure its survival.
Traditional kite game as an effort to overcome stress for elementary school students during the covid-19 pandemic
Authors: Budiman Indra Adi , Hendrayana Yudy , Sofyan Davi
Published: April 2023

The purpose of this research is to carry out a traditional game, especially a kite, as an effort to overcome stress in elementary school students during the COVID-19 pandemic. Quantitative research with the type of survey research is carried out in this study. The sample in this study amounted to 10 students. The sample was selected based on being domiciled in a block whose houses were not far apart so that it was easy to condition them. The distribution of questionnaires and performing organized interviews with parents and kids make up the data collection process. In this study, the Lovibond and Lovibond DASS (Depression Anxiety Stress Scale) questionnaire 42 was utilized. Both quantitative and qualitative descriptive methodologies were used to analyze the data. The findings demonstrated that the scores obtained were based on DASS 42 from the circumstances before the test to overcome stress with kite flying and after. Before the trial, the stress value was 31.7, then after that, there was a decrease of around 16.7, which is in the range of 15. Thus, overcoming stress through the traditional kite game is considered quite successful for elementary school students during the COVID-19 pandemic. There are limitations in this study because it is not able to describe the situations of students with a larger scope, different cultures, physical conditions, and urban play environments. Recommendations for further researchers to conduct research for students in overcoming stress against high pressure in the learning process through the form of methods, strategies, and other games.
A Fast and Minimal System to Identify Depression Using Smartphones: Explainable Machine Learning–Based Approach
Authors: Ahmed Md Sabbir , Ahmed Nova
Published: April 2023

Background

Existing robust, pervasive device-based systems developed in recent years to detect depression require data collected over a long period and may not be effective in cases where early detection is crucial. Additionally, due to the requirement of running systems in the background for prolonged periods, existing systems can be resource inefficient. As a result, these systems can be infeasible in low-resource settings.

Objective

Our main objective was to develop a minimalistic system to identify depression using data retrieved in the fastest possible time. Another objective was to explain the machine learning (ML) models that were best for identifying depression.

Methods

We developed a fast tool that retrieves the past 7 days’ app usage data in 1 second (mean 0.31, SD 1.10 seconds). A total of 100 students from Bangladesh participated in our study, and our tool collected their app usage data and responses to the Patient Health Questionnaire-9. To identify depressed and nondepressed students, we developed a diverse set of ML models: linear, tree-based, and neural network–based models. We selected important features using the stable approach, along with 3 main types of feature selection (FS) approaches: filter, wrapper, and embedded methods. We developed and validated the models using the nested cross-validation method. Additionally, we explained the best ML models through the Shapley additive explanations (SHAP) method.

Results

Leveraging only the app usage data retrieved in 1 second, our light gradient boosting machine model used the important features selected by the stable FS approach and correctly identified 82.4% (n=42) of depressed students (precision=75%, F1-score=78.5%). Moreover, after comprehensive exploration, we presented a parsimonious stacking model where around 5 features selected by the all-relevant FS approach Boruta were used in each iteration of validation and showed a maximum precision of 77.4% (balanced accuracy=77.9%). Feature importance analysis suggested app usage behavioral markers containing diurnal usage patterns as being more important than aggregated data-based markers. In addition, a SHAP analysis of our best models presented behavioral markers that were related to depression. For instance, students who were not depressed spent more time on education apps on weekdays, whereas those who were depressed used a higher number of photo and video apps and also had a higher deviation in using photo and video apps over the morning, afternoon, evening, and night time periods of the weekend.

Conclusions

Due to our system’s fast and minimalistic nature, it may make a worthwhile contribution to identifying depression in underdeveloped and developing regions. In addition, our detailed discussion about the implication of our findings can facilitate the development of less resource-intensive systems to better understand students who are depressed and take steps for intervention.
Artificial Intelligence Supporting the Training of Communication Skills in the Education of Health Care Professions: Scoping Review
Authors: Stamer Tjorven , Steinhäuser Jost , Flägel Kristina
Published: April 2023

Background

Communication is a crucial element of every health care profession, rendering communication skills training in all health care professions as being of great importance. Technological advances such as artificial intelligence (AI) and particularly machine learning (ML) may support this cause: it may provide students with an opportunity for easily accessible and readily available communication training.

Objective

This scoping review aimed to summarize the status quo regarding the use of AI or ML in the acquisition of communication skills in academic health care professions.

Methods

We conducted a comprehensive literature search across the PubMed, Scopus, Cochrane Library, Web of Science Core Collection, and CINAHL databases to identify articles that covered the use of AI or ML in communication skills training of undergraduate students pursuing health care profession education. Using an inductive approach, the included studies were organized into distinct categories. The specific characteristics of the studies, methods and techniques used by AI or ML applications, and main outcomes of the studies were evaluated. Furthermore, supporting and hindering factors in the use of AI and ML for communication skills training of health care professionals were outlined.

Results

The titles and abstracts of 385 studies were identified, of which 29 (7.5%) underwent full-text review. Of the 29 studies, based on the inclusion and exclusion criteria, 12 (3.1%) were included. The studies were organized into 3 distinct categories: studies using AI and ML for text analysis and information extraction, studies using AI and ML and virtual reality, and studies using AI and ML and the simulation of virtual patients, each within the academic training of the communication skills of health care professionals. Within these thematic domains, AI was also used for the provision of feedback. The motivation of the involved agents played a major role in the implementation process. Reported barriers to the use of AI and ML in communication skills training revolved around the lack of authenticity and limited natural flow of language exhibited by the AI- and ML-based virtual patient systems. Furthermore, the use of educational AI- and ML-based systems in communication skills training for health care professionals is currently limited to only a few cases, topics, and clinical domains.

Conclusions

The use of AI and ML in communication skills training for health care professionals is clearly a growing and promising field with a potential to render training more cost-effective and less time-consuming. Furthermore, it may serve learners as an individualized and readily available exercise method. However, in most cases, the outlined applications and technical solutions are limited in terms of access, possible scenarios, the natural flow of a conversation, and authenticity. These issues still stand in the way of any widespread implementation ambitions.
Fibroblast Activation Protein Overexpression in Gastrointestinal Tumors: Protocol for a Systematic Review and Meta-analysis
Authors: Sunami Yoshiaki , Ronellenfitsch Ulrich , Kleeff Jorg , Rebelo Artur
Published: April 2023

Background

A hallmark of gastrointestinal cancer, especially pancreatic cancer, is the dense stromal tumor microenvironment in which cancer-associated fibroblasts (CAFs) represent the major stromal cell type. Preclinical studies have demonstrated that depletion of fibroblast activation protein (FAP)–positive CAFs results in increased survival.

Objective

We present the protocol for a systematic review and meta-analysis that aim to assess the currently available evidence on the effect of FAP expression on survival and clinical characteristics in gastrointestinal cancers.

Methods

The literature search and data analysis will be conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement. The databases PubMed/MEDLINE, Web of Science Core Collection, Cochrane Library, and ClinicalTrials.gov will be searched via their respective online search engines. A meta-analysis comparing patients with and without FAP overexpression with the following outcomes will be performed: postoperative survival (overall and median survival; 1-, 2-, 3-, and 5-year survival rates), histological differentiation (grading), local tumor invasion, lymph node metastases, and distant metastases. Odds ratios will be calculated for binary data, and weighted mean differences and relative SD differences will be determined for continuous data. The 95% CI, heterogeneity measures, and statistical significance will be reported for each outcome. The chi-square and Kruskal-Wallis tests will be used to evaluate statistical significance. A P value of <.05 will be considered statistically significant.

Results

Database searches will commence in April 2023. The meta-analysis will be completed by December 2023.

Conclusions

In recent years, several publications on FAP overexpression in gastrointestinal tumors have been published. The only published meta-analysis on this topic dates to 2015. It included 15 studies on various solid tumors and only 8 studies focusing exclusively on gastrointestinal tumors. The expected results of the present analysis will provide new evidence on the prognostic value of FAP in gastrointestinal tumors and thereby support health care professionals and patients in their decision-making.

Trial Registration

PROSPERO CRD42022372194; https://tinyurl.com/352ae8b8

International Registered Report Identifier (IRRID)

PRR1-10.2196/45176
An Evaluation of the Design of Multimedia Patient Education Materials in Musculoskeletal Health Care: Systematic Review (Preprint)
Authors: Van Oirschot Garett , Pomphrey Amanda , Dunne Caoimhe , Murphy Kate , Blood Karina , Doherty Cailbhe
Published: April 2023

BACKGROUND

Educational multimedia is a cost-effective and straightforward way to administer large-scale information interventions to patient populations in musculoskeletal health care. While an abundance of health research informs the content of these interventions, less guidance exists about optimizing their design.

OBJECTIVE

This study aims to identify randomized controlled trials of patient populations with musculoskeletal conditions that used multimedia-based patient educational materials (PEMs) and examine how design was reported and impacted patients’ knowledge and rehabilitation outcomes. Design was evaluated using principles from the cognitive theory of multimedia learning (CTML).

METHODS

PubMed, CINAHL, PsycINFO, and Embase were searched from inception to September 2023 for studies examining adult patients with musculoskeletal conditions receiving multimedia PEMs compared to any other interventions. The primary outcome was knowledge retention measured via test scores. Secondary outcomes were any patient-reported measures. Retrievability was noted, and PEMs were sourced through search, purchase, and author communication.

RESULTS

A total of 160 randomized controlled trials were eligible for inclusion: 13 (8.1%) included their educational materials and 31 (19.4%) required a web search, purchase, or direct requests for educational materials. Of these 44 (27.5%) studies, none fully optimized the design of their educational materials, particularly lacking in the CTML principles of coherence, redundancy, modality, and generative activities for the learner. Of the 160 studies, the remaining 116 (72.5%) contained interventions that could not be retrieved or appraised. Learning was evaluated in 5 (3.1%) studies.

CONCLUSIONS

Musculoskeletal studies should use open science principles and provide their PEMs wherever possible. The link between providing multimedia PEMs and patient learning is largely unexamined, but engagement potential may be maximized when considering design principles such as the CTML.
Game player types and perceptual learning style preferences among nursing students: A cross-sectional study (Preprint)
Authors: Jeong EunYoung
Published: April 2023

BACKGROUND

Attempts to introduce gamification in classrooms are increasing, but this has mainly been restricted to elementary and secondary education. Attempts directed at university level education are scarce. It is necessary to analyze how the primary users play games before developing a gamification program, as it facilitates the successful implementation of the program.

OBJECTIVE

This cross-sectional study aimed to analyze game player types and learning preferences among nursing students to aid the development of educational gamification programs and examine the correlation between player types and perceptual learning style preference (PLSP).

METHODS

: Recruitment notices were posted on social network services that are frequently visited by nursing students to introduce the research elements. Self-administered questionnaires were distributed to nursing students nationwide from March 24 to June 9, 2022. The self-administered questionnaire consisted of 48 questions, including the player’s type, learning type, and general characteristics. Player types were assessed using the “Bartle's Player Type Classification” questionnaire. The survey comprised 24 items, with six questions for each of the four player types. Learning style preference was gauged using the Korean version of Reid’s PLSP questionnaire, which comprises 20 items, with five items each for visual, auditory, tactile, and kinesthetic styles.

RESULTS

: Data from 343 responses were included in the analysis. The most common game player type was the socializers (n=179, 34.5%), followed by explorers (n=170, 32.8%), achievers (n=138, 26.6%), and killers (n=32, 6.2%). The most frequent PLSP was the auditory type (n=140, 31.7%), whereas visual (n=126, 28.5%), tactile (n=90, 20.4%), and kinesthetic (n=86, 19.5%) styles were less preferred. Bartle’s player type and Reid’s PLSP showed a statistically meaningful correlation. Achievers showed the strongest positive correlation with auditory style (r=.298, P<.001) whereas explorers showed the strongest positive correlation with the kinesthetic style (r=.488, P<.001). Killers, unlike other player types, showed a positive correlation with only the visual style (r=.110, P=.027).

CONCLUSIONS

When developing gamification programs for nursing students, player types and learning preferences of the primary users play a key role in the successful implementation of the program. These findings can contribute to the development of gamification programs for nursing university students.
Pathogenic Gene Spectrum and Clinical Implication in Chinese Patients with Lupus Nephritis
Authors: Zhang Changming , Han Xu , Jin Ying , Chen Xiang , Gong Cheng , Peng Jiahui , Wang Yusha , Luo Xiaoxin , Yang Zhaohui , Zhang Yangyang , Wan Weiguo , Liu Xiaohui , Mao Jianhua , Yu Haiguo , Li Jingyi , Liu Li , Sun Li , Yang Sirui , An Yu , Liu Zhengzhao , Gao Erzhi , Zhu Honghao , Chen Yinghua , Yu Xiaomin , Zhou Qing , Liu Zhihong
Published: April 2023

Background

Lupus nephritis is a rare immunological disorder. Genetic factors are considered important in its causation. We aim to systematically investigate the rare pathogenic gene variants in patients with lupus nephritis.

Methods

Whole-exome sequencing was used to screen pathogenic gene variants in 1886 probands with lupus nephritis. Variants were interpreted on the basis of known pathogenic variants or the American College of Medical Genetics and Genomics guidelines and studied by functional analysis, including RNA sequencing, quantitative PCR, cytometric bead array, and Western blotting.

Results

Mendelian form of lupus nephritis was confirmed in 71 probands, involving 63 variants in 39 pathogenic genes. The detection yield was 4%. The pathogenic genes enriched in nuclear factor kappa-B (NF-κB), type I interferon, phosphatidylinositol-3-kinase/serine/threonine kinase Akt (PI3K/AKT), Ras GTPase/mitogen-activated protein kinase (RAS/MAPK), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways. Clinical manifestation patterns were diverse among different signaling pathways. More than 50% of the pathogenic gene variants were reported to be associated with lupus or lupus nephritis for the first time. The identified pathogenic gene variants of lupus nephritis overlapped with those of autoinflammatory and immunodeficiency diseases. Inflammatory signatures, such as cytokine levels of IL-6, IL-8, IL-1β, IFNα, IFNγ, and IP10 in serum and transcriptional levels of interferon-stimulated genes in blood, were significantly higher in patients with pathogenic gene variants compared with controls. The overall survival rate of patients with pathogenic gene variants was lower than those without pathogenic gene variants.

Conclusions

A small fraction of patients with lupus nephritis had identifiable pathogenic gene variants, primarily in NF-κB, type I interferon, PI3K/AKT, JAK/STAT, RAS/MAPK, and complement pathways.