bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factor analysis and risk prediction model of arrhythmia after Da Vinci robotic cardiac surgery
Authors: Wu Wenjun , Ding Renzhong , Chen Jianming , Yuan Ye , Song Yi , Yan Manrong , Hu Yijie
Published: September 2022

Background:To analyze the safety and efficacy of Da Vinci robotic cardiac surgery, to investigate the risk factors of postoperative arrhythmia and to establish a risk prediction model. Methods:The data of 147 patients who underwent cardiac surgery under Da Vinci robotic cardiopulmonary bypass (CPB) from July 2016 to June 2022 in Daping Hospital of Army Medical University were retrospectively analyzed, and their demographic data and related clinical data were statistically analyzed. The mean age was (43.03±13.11) years, 55 (37.41%) were male and 92 (62.59%) were female. According to whether arrhythmia occurred after operation, the patients were divided into two groups: 23 patients with arrhythmia and 123 patients without arrhythmia. Univariate analysis was performed for perioperative risk factors in the two groups, and then multivariate logistic analysis was performed for selected variables with more significance to establish a regression model and evaluate the prediction model using receiver operating characteristic curve (ROC curve). Results: Arrhythmia occurred in 23 of 147 patients (15.75%) after Da Vinci robotic cardiac surgery, and 1 patient (0.68%) died in the hospital.Univariate analysis of arrhythmia after Da Vinci robotic cardiac surgery suggested that age, body weight, body mass index (BMI), diabetes, New York Heart Association (NYHA) class, left atrial anteroposterior diameter (LAD), left ventricular anteroposterior diameter (LVDs), right ventricular anteroposterior diameter (RVDs), total bilirubin (TBIL), direct bilirubin (DBIL), uric acid (UA), red blood cell width (RDW), operation time, CPB time, aortic cross-clamp time, and operation type were statistically analyzed and associated with postoperative arrhythmia (P<0.05).Multivariate binary logistic regression analysis suggested that DBIL (OR=1.334,95%CI1.003–1.774,P=0.048) and aortic cross-clamp time (OR=1.018,95%CI1.005–1.031,P=0.008) were independent risk factors for arrhythmia after Da Vinci robotic cardiac surgery.In arrhythmia group, postoperative tracheal intubation time (P<0.001), intensive care unit stay (P<0.001) and postoperative hospital stay (P<0.001) were significantly prolonged, and postoperative high-dose blood transfusion events were significantly increased (P=0.002).The area under the curve (AUC) of ROC was 0.849 (95%CI0.769–0.930, P<0.001), the cutoff point was 0.574, the model sensitivity was 82.6%, and the specificity was 74.8%. Conclusion:Preoperative DBIL level and aortic cross-clamp time were independent risk factors of arrhythmia after Da Vinci robotic cardiac surgery; postoperative tracheal intubation time, intensive care unit stay and postoperative hospital stay were significantly prolonged in patients with postoperative arrhythmia, and postoperative high-dose blood transfusion events were significantly increased; risk prediction model had certain predictive value for postoperative arrhythmia.
The pre-stroke induction and normalization of insulin resistance respectively worsens and improves functional recovery
Authors: Vercalsteren Ellen , Karampatsi Dimitra , Dekens Doortje , Letsiou Aikaterini , Zabala Alexander. , Romanitan Mihaela , Klein Thomas , Nyström Thomas , Darsalia Vladimer , Patrone Cesare
Published: September 2022

Background
Type 2 diabetes (T2D) impairs post-stroke functional recovery, and the underlying mechanisms are mostly unknown. Insulin resistance (IR), which is a hallmark of T2D, also afflicts up to 50% of the elderly without T2D. IR has been associated with impaired recovery after stroke. However, the causative role of IR in impaired stroke recovery has not been demonstrated. By using different mouse models of early IR, we investigated the potential crosstalk between IR and stroke recovery as well as some of the cellular mechanisms possibly involved.
Methods
We used three different models of IR. Early IR with or without fasting hyperglycaemia was respectively induced by 4 months of high fat diet or by 30% sucrose supplementation in the drinking water. In addition, we used 10-month-old mice that spontaneously develop IR, but not hyperglycaemia, and where IR was targeted pharmacologically pre-stroke with 10 mg/kg/day Rosiglitazone. Stroke was induced by transient middle cerebral artery occlusion and post-stroke recovery was assessed by sensorimotor tests. Neuronal survival, neuroinflammation and neuroplasticity mediated by cholinergic interneurons were assessed by immunohistochemistry/quantitative microscopy.
Results
The induction of IR before stroke, with or without hyperglycaemia, impaired post-stroke neurological recovery. Moreover, the results indicate the involvement of increased neuroinflammation and decreased cholinergic interneuron-mediated neuroplasticity in the recorded effects. Importantly, the pharmacological normalization of IR, significantly improved post-stroke neurological recovery.
Conclusion
The global diabetes epidemic and world population aging are dramatically increasing the percentage of people in need of post-stroke treatment and care. Targeting hyperglycaemia acutely post-stroke has so far provided negative results to improve stroke outcome and new targets are highly needed. The results of our study suggest that future clinical studies should focus on the specific targeting of pre-stroke IR to reduce the sequelaeof stroke in both diabetic patients and the elderly suffering from prediabetes.
Transcatheter Fontan fenestration closure: sustained improvements in oxygen saturation with minimal morbidity and mortality
Authors: Devanagondi Rajiv , Leonard Glenn
Published: September 2022

Background:
Fontan fenestration decreases central venous pressure and preserves cardiac output while decreasing systemic oxygen saturation. Transcatheter fenestration closure increases oxygen saturation, though the persistence of this increase and the long-term incidence of adverse outcomes such as death and heart transplant remain unknown. We describe immediate and long-term clinical and adverse outcomes following fenestration closure.
Methods:
Catheterization, echocardiogram, and clinic reports were reviewed following transcatheter Fontan fenestration closure. Data were reported as n (%) and median (IQR). Continuous variables were compared using Wilcoxon ranked sum test.
Results:
51 patients had fenestration closure 0.9 (0.7–1.5) years following extra-cardiac Fontan operation. Most (84%) were closed with Amplatzer Septal Occluders. Systemic O2 saturation immediately increased from 87 (83–89)% to 95 (94–97)%, p < 0.05. Cardiac index decreased from 4 (3–5) to 2.9 (2.6–3.5) L/min/m2. Fontan pressure and pulmonary vascular resistance were not significantly changed. Clinical follow up duration for all patients was 7.3 (range 1.3–16) years. Oxygen saturation at last follow up was 94.5 (92–97)% and did not decrease over time (p < 0.05). One patient (2%) developed protein losing enteropathy, 1 (2%) had heart transplant, and 1 (2%) patient died 9.4 years following fenestration closure. No patient required fenestration re-creation following closure.
Conclusions:
Transcatheter Fontan fenestration closure leads to sustained increases in systemic oxygen saturation and a low incidence of adverse outcomes such as death and transplant. Further study comparing fenestration closure to non-closure and longer follow up duration are required to determine if there is a survival benefit to fenestration closure.
Development of a Predictive Model of Prostate cancer: Integration of a Panel of Formerly N-linked Glycopeptides and Clinical Variables for Serum Testing
Authors: Gabriele Caterina , Aracri Federica , Prestagiacomo Licia Elvira , Rota Maria Antonietta , Alba Stefano , Tradigo Giuseppe , Guzzi Pietro H. , Cuda Giovanni , Damiano Rocco , Veltri Pierangelo , Gaspari Marco
Published: September 2022

Background: Prostate Cancer (PCa) represents the second leading cause of cancer-related death in men. Prostate-specific antigen (PSA) is currently used for PCa screening but because of its low specificity and sensitivity new diagnostic tools are required.
Methods: In this work, 32 formerly N-glycosylated peptides were quantified by PRM in 163 serum samples (79 from PCa patients and 84 from individuals affected by benign prostatic hyperplasia (BPH)) in two technical replicates. These potential biomarker candidates were prioritized through a multi-stage biomarker discovery pipeline articulated in: discovery, LC-PRM assay development and verification phases. Because of the well-established involvement of glycoproteins in cancer development and progression, the proteomic analysis was focused on glycoproteins enriched by TiO2 strategy.
Results: Machine learning algorithms have been applied to the combined matrix comprising proteomic and clinical variables, resulting in a predictive model based on six proteomic variables (LAMB1, LAMP2, LUM, TFRC, NCAM1, GPLD1) and five clinical variables (prostate dimension, proPSA, free-PSA, total-PSA, free/total-PSA).
Conclusions: A predictive model combining proteomic and clinical variables able to distinguish PCa from BPH with an AUC of 0.82 was developed. This model outperformed PSA alone which, on the same sample set, was able to discriminate PCa from BPH with an AUC of 0.74. Data are available via ProteomeXchange with identifier PXD035935.
Nomograms for predicting overall survival and cancer-specific survival in elderly patients with epithelial ovarian cancer
Authors: Cheng Hao , Xu Jin-Hong , Wu Chen-Chen , Tang Xiao-Nan , Chen Mei-Ling , Lian Zhu-Sheng , Li Ning , Xu Xue-Lian
Published: September 2022

Background
Epithelial ovarian cancer (EOC) is one of the most fatal gynecological malignancies among elderly patients. We aim to construct two nomograms to predict the overall survival (OS) and cancer-specific survival (CSS) in elderly EOC patients.
Methods
Elderly patients with EOC between 2000 and 2019 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Enrolled patients were randomly divided into the training and validation set at a ratio of 7:3. The OS and CSS were recognized as endpoint times. The independent prognostic factors from the multivariate analysis were used to establish nomograms for predicting the 3-, 5- and 10-year OS and CSS of elderly EOC patients. The improvement of predictive ability and clinical benefits were evaluated by consistency index (C-index), receiver operating characteristic (ROC), calibration curve, decision curve (DCA), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Finally, the treatment efficacy of surgery and chemotherapy in low-, medium-, and high-risk groups were displayed by Kaplan-Meier curves.
Results
A total of 5,588 elderly EOC patients were obtained and randomly assigned to the training set (n = 3724) and validation set (n = 1864). The independent prognostic factors were utilized to construct nomograms for OS and CSS. The C-index of the OS nomogram and CSS nomogram were 0.755 and 0.700 in the training cohort. In the validation cohort, the C-index of the OS nomogram and CSS nomogram were 0.746 and 0.696. The calibration curve demonstrated good concordance between the predicted survival rates and actual observations. Moreover, the NRI, IDI, and DCA curves determined the outperformance of the nomogram compared with the AJCC stage system. Besides, surgery had no benefit on the prognosis in the high-risk group. Chemotherapy had a better prognosis in the medium-, and high-risk groups, but not for the low-risk group.
Conclusions
We developed and validated nomograms for predicting OS and CSS in elderly EOC patients to help gynecologists to develop an appropriate individualized therapeutic schedule.
Placental mesenchymal stem cells ameliorate NLRP3 inflammasome induced ovarian insufficiency by modulating macrophage M2 polarization
Authors: Chen Dongmei , Hu Na , Xing Shasha , Yang Li , Zhang Feiyan , Guo Songlin , Liu shudan , Ma Xiaona , Liang Xueyun , Ma Huiming
Published: September 2022

Background: Premature ovarian insufficiency (POI) is a common clinical problem but there are currently no effective therapies. Pyroptosis induced by the NLRP3 inflammasome is considered a possible mechanism of POI. Placental mesenchymal stem cells(PMSCs) have excellent immunomodulatory potential and offer a promising method for treating POI.
Methods: Female Sprague–Dawley rats were randomly divided into four treatment groups: control (no POI), POI with no PMSCs, POI with PMSCs transplant, and POI with hormones (estrogen+progesterone) as positive control. POI was induced by exposure to 4-vinylcyclohexene diepoxide (VCD) for 15 days. After four weeks, all animals were euthanized and examined for pathology. Hormone levels were measured and ovarian function was evaluated in relation to the estrous cycle. Levels of NLRP3 inflammasome pathway proteins were determined by immunohistochemistry and western blot.
Results: VCD significantly damaged rat follicles at different estrous stages. Injection of human PMSCs improved ovarian function and reproductive ability of POI rats compared to the sham and hormone groups. Our data also showed that PMSCs could remarkably suppress cell pyroptosis via downregulation of the NLRP3 inflammasome, caspase-1, IL-1β and IL-18 compared to the other two groups. The human PMSCs increased the expression of IL-4 and IL-10 and decreased pro-inflammatory factors by phenotypic changes in macrophages.
Conclusions: Our findings revealed a novel mechanism of follicular dysfunction and ovarian fibrosis via activation of the NLRP3 inflammasome followed by secretion of pro-inflammatory factors. Transplantation of PMSCs into POI rats suppressed pro-inflammatory factor production, NLRP3 inflammasome formation and pyroptosis, and improved ovarian function.
C6orf15 acts as a potential novel marker of adverse pathological features and prognosis for colon cancer
Authors: Xiong Xiaoyu , Wang Shuo , Ye Yingjiang , Gao Zhidong
Published: September 2022

Objective To investigate the expression of chromosome 6 open reading frame 15 (C6orf15) in colon cancer and its effects on clinicopathological features and prognosis.
Methods Using the transcriptome and clinical data of colon cancer and normal tissues in The Cancer Genome Atlas (TCGA) database, the expression of C6orf15 mRNA in colon cancer samples and its relationship with clinicopathological characteristics and prognosis were explored. The expression level of C6orf15 protein in 23 colon cancer tissues was detected by immunohistochemistry (IHC). The possible mechanism of C6orf15 involved in the occurrence and development of colon cancer was explored by gene set enrichment analysis (GSEA).
Results Compared with normal tissues, C6orf15 was highly expressed in colon cancer (1.207±0.694 vs. 0.276±0.166, t=8.281, P<0.01). The expression level of C6orf15 was associated with tumor invasion depth (χ2=8.30, P=0.04), lymph node metastasis (χ2=36.97, P<0.001), distant metastasis (χ2=8.69, P=0.003), pathological stage (χ2=34.17, P<0.001). High expression of C6orf15 was associated with poor prognosis (χ2=6.43, P<0.05). The results of GSEA showed that C6orf15 promotes the occurrence and development of colon cancer by promoting the ECM receptor interaction pathway, Hedgehog signaling pathway and Wnt signaling pathway. Immunohistochemical results showed that the expression of C6orf15 protein in colon cancer tissues was correlated with the depth of invasion (P=0.023) and lymph node metastasis (P=0.048).
Conclusion C6orf15 is highly expressed in colon cancer tissue and is related to adverse pathological features and poor prognosis of colon cancer. It is involved in multiple oncogenic signaling pathways and may serve as a prognostic marker of colon cancer.
Characterization of Nickel and Gold Mined-out Areas of Taganito Mining Corporation and Manila Mining Corporation, Claver and Placer, Surigao del Norte, Philippines
Authors: Bethlehem Marie T. , Magsayo Bethlehem Marie , Bacosa Hernando P. , Aggangan Nelly S. , Gilbero Dennis M. , Amparado Ruben F. , Guihawan Jaime
Published: September 2022

Mining industries are mandated by law to rehabilitate their mined-out areas. The waste materials, also called as mine tailings are left after the extraction of minerals have caused several environmental problems such as contamination and alteration of soil profiles, and the pollution and contamination of waterbodies. Experience in the Philippines indicates that mining companies are facing major difficulties in rehabilitating mined-out areas and tailings especially in raising potential nursery seedlings. Much more in outplanting raised nursery seedlings since mortality rates are high. The mined-out areas facing such problems are the nickel and gold mined-out areas in Taganito Mining Corporation (TMC) and Manila Mining Corporation (MMC) located in Claver and Placer, Surigao del Norte, respectively. This study assessed and characterized a cross section of their mined out areas in terms of the amount of residual heavy metal concentration in the soil, determine the current soil nutrient status and provide useful implications of the current physico-chemical properties of the mined-out soils. Results show that the soils in both sites need to be amended with compost (1:1 ratio), fertilizer (NPK) and microbial biofertilizers to ensure success in the rehabilitation efforts. TMC soils have deficient to low nutrient availability (%organic matter, total nitrogen, available P and exchangeable K) and have high nickel (7,166 ppm) content which is an order of magnitude higher than the Dutch standard intervention value of 210 ppm. On the other hand, MMC soils have low to moderate nutrient availability and a pH value of 6.14. Additionally, MMC soils have high concentration of molybdenum and copper with 39, 400 ppm and 449.2 ppm, respectively which extremely exceeded the Dutch standard intervention value of 200 ppm (molybdenum) and 190 ppm (copper). These values indicate serious contamination of soils and immediate remediation is highly recommended. It is likewise further recommended the use of native soils with biofertilizer amendments in the much needed seedling production for the massive rehabilitation efforts of these mining companies. Use of native plant species for nursery seedling production is highly recommended to be used in the rehabilitation efforts to ensure better coping mechanism and higher rates of survival when introduced into the mined-out soils. Bioremediation is highly recommended as a rehabilitation strategy in the mined-out areas of Taganito Mining Corporation and Manila Mining Corporation in Claver and Placer, Surigao del Norte, respectively. This method is environment-friendly, low-cost, a simple technology and ensures long-term solution in mined-out area rehabilitation.
Effects of dietary protein sources and their adequacy on muscle function, body composition, and risk of sarcopenic obesity in South Korean populations: A cross-sectional study
Authors: Kim Jieun , Jeong Kyoungsik , Lim Sueun , Lee Siwoo , Baek Younghwa
Published: September 2022

Background

Dietary protein sources and protein adequacy are crucial modulators of muscle quality and body composition. We investigated the association between dietary protein sources (and their adequacy) and prevalence of sarcopenic obesity (SO) in South Korean populations according to weight status.

Methods

The participants (n = 1,967) were classified into SO, obese, sarcopenia, and normal groups. A cross-sectional survey was conducted using the KS-15 questionnaire, short-form Food Frequency Questionnaire, and anthropometric measurements.

Results

Percentage of body fat (male: 28.43 ± 0.61%; female: 39.95 ± 0.36%) was significantly high, while appendicular skeletal muscle (ASM; male: 40.30 ± 0.36%, female: 32.47 ± 0.20%) was low in the SO and OB groups. Beef and pork consumption was negatively associated with ASM (%) but positively associated with body fat (kg and %) in the normal group. Among the people with excessive protein intake, the lowest quintile (Q1: 5.7 g/day) of beans and tofu consumption showed a 2.4-fold increase in the risk of developing SO (adjusted odds ratio: 2.41, confidence interval: 1.07–7.80), when compared with the highest quintile (Q5: 60.1 g/day). Similarly, with beans and tofu consumption, there was a 2.5-fold higher risk of developing sarcopenia in participants who had < 5.7 g/day intake in the excessive protein intake individuals.

Conclusions

Daily poultry and egg intake was positively linked with muscle function in the participants with sarcopenia, while red meat showed a negative effect on imbalanced body composition with increased fat mass (kg and %) and decreased ASM (%) in participants with normal weight. Furthermore, lower intake of healthy protein foods, such as beans and tofu or poultry and eggs, was strongly associated with SO prevalence in people who consumed excessive daily dietary protein.
Rational Choice of a Basket for the Rotational Vibropriller
Authors: YURCHENKO OLEKSANDR , Sklabinskyi V. , Ochowiak Marek , Ostroha Ruslan , Gusak Oleksandr
Published: September 2022

The use of processing units for the production of mineral fertilizers in the industry in today’s market requires improved product quality and increased productivity. As a result, there is a need to change the design of existing units or some structural elements. Rotary vibroprillers, having a relatively simple design, can be of different designs that directly affect the productivity indicators mentioned above. The study considers the influence of the shape of the basket bottom on the quality of the rotational vibroprillers. After using the governing equation of prills motion in the airflow, a program was developed for automatic control of the rotational speed of the priller based on changes in melt loads. It is established that the size of the spray swath can be changed by varying the rotational speed of the priller. There is a tendency to affect the vibropriller performance by controlling the rotational speed and shape of the basket bottom without performance degradation.
Effect of Phosphogypsum Addition on Methane Yield in Biogas and Digestate Properties During Anaerobic Digestion
Authors: Chubur V. , Chernysh Y. , Ferchau E. , Zaffar N.
Published: September 2022

The study discussed the use of phosphogypsum by-product waste in anaerobic digestion processes. Besides the production of biogas from plant substrate with the addition of phosphogypsum, the focus was placed on the enrichment of digestate with phosphogypsum as a mineral additive to increase the concentration of valuable macro-and microelements. The component composition of the obtained digestates was analyzed, and opportunities for additional research were determined. Research on the use of mineral additives in anaerobic digestion is considered promising. Phosphogypsum favors the quality of digestate as an organic mineral fertilizer with a higher content of mineral components. Furthermore, the contribution of phosphogypsum to plant substrate to achieve higher biogas production is not apparent, but with an impact on the component composition of biogas; however, there is an opportunity to consider the potential benefits of using the additive with another type of substrate waste for the anaerobic digestion process.
A capacitação de empreendedores do município de Santa Cruz de Minas para a inserção em ambientes digitais do comércio eletrônico
Authors: BARROS Leandro Eduardo Vieira , SOUZA Celso Luis de , CABRAL Fernanda Morais , SANTOS Lívia da Silva , CALSAVARA Daniele Letícia , SANTOS Jhonatas Luiz dos , NASCIMENTO João Miguel Ferreira , PATROCINIO Sérgio Hilario do
Published: September 2022

A economia do município de Santa Cruz de Minas, no estado de Minas Gerais, tem como um dos principais pilares a produção e a venda de artesanato e de móveis de madeira. O município se beneficia do turismo regional para a comercialização de seus produtos, porém, com as restrições provenientes da pandemia COVID-19, as vendas diminuíram. Nesse contexto, foi desenvolvido um projeto que teve como objetivo capacitar os empreendedores locais, propiciando a inserção de seus produtos no e-commerce, para aumentar suas receitas. O projeto trabalhou de forma interdisciplinar com bolsistas que tiveram um treinamento prévio por meio de cursos. Foram elaborados materiais sobre as ferramentas do mercado digital considerando as demandas de cada empresa. Apesar da falta de disponibilidade de tempo e de pouco conhecimento tecnológico, os empreendedores se prontificaram em otimizar as práticas empregadas nos próprios empreendimentos e, com isso, geram um ganho de qualidade na gestão das redes sociais e demais ferramentas.
A novel approach for calculating the item discrimination for Likert type of scales
Authors: ÇELEN Ümit , AYBEK Eren Can
Published: September 2022

Item analysis is performed by developers as an integral part of the scale development process. Thus, items are excluded from the scale depending on the item analysis prior to the factor analysis. Existing item discrimination indices are calculated based on correlation, yet items with different response patterns are likely to have a similar item discrimination index. This study proposed a new item discrimination index that can be used in Likert type of scales and examined its effect on factor analysis results. For this purpose, simulative datasets were generated, and items were excluded from the analysis according to the .20, .30 and .35 item discrimination index criteria, and exploratory factor analysis was performed for a single factor. Accordingly, it was found that more variance could be explained by a single factor with fewer items compared to other discrimination indices when the .20 criterion of the slope coefficient was used as suggested in this study. Similar findings were obtained using the .35 criterion with other discrimination indices. In this context, it is recommended to use the slope coefficient as an additional discrimination index calculation method in the scale development process.
Covariant entanglement wedge cross-section, balanced partial entanglement and gravitational anomalies
Authors: Wen Qiang , Zhong Haocheng
Published: September 2022

The balanced partial entanglement (BPE) was observed to give the reflected entropy and the entanglement wedge cross-section (EWCS) for various mixed states in different theories [1,2]. It can be calculated in different purifications, and is conjectured to be independent from purifications. In this paper we calculate the BPE and the EWCS in generic covariant scenarios in two-dimensional CFTs with and without gravitational anomalies, and find that they coincide with the reflected entropy. In covariant configurations we determine the partition for the purifying system with the help of the gravitational anomalies, and we extend our discussion to topological massive gravity (TMG). We give the first prescription to evaluate the entropy quantity associated to the EWCS beyond Einstein gravity, i.e. the correction to the EWCS from the Chern-Simons term in TMG. Apart from the gravity theory and geometry, further input from the mixed state should be taken into account.
Rapid detection of phase transitions from Monte Carlo samples before equilibrium
Authors: Ding Jiewei , Tang Ho-Kin , Yu Wing Chi
Published: September 2022

We found that Bidirectional LSTM and Transformer can classify different phases of condensed matter models and determine the phase transition points by learning features in the Monte Carlo raw data before equilibrium. Our method can significantly reduce the time and computational resources required for probing phase transitions as compared to the conventional Monte Carlo simulation. We also provide evidence that the method is robust and the performance of the deep learning model is insensitive to the type of input data (we tested spin configurations of classical models and green functions of a quantum model), and it also performs well in detecting Kosterlitz-Thouless phase transitions.
Evaluation of Psychological Distress in Infertile Women who Underwent ART Cycle During the COVID-19 Pandemic
Authors: Cogendez Ebru , Kumru Pinar , Soysal Sunullah , Ozkaya Enis , Devranoglu Belgin , Tozkir Elif , Sanverdi Ilhan
Published: September 2022

OBJECTIVE: We aimed to determine the frequency of psychological distress and related factors in infertile women who underwent assisted reproductive technologies during the COVID-19 pandemic and to develop health policies accordingly.
STUDY DESIGN: This cross-sectional study was carried out with 352 infertile women who applied to the in vitro fertilization clinic between December 2020-February 2021. In the face-to-face survey study, five questionnaires were given to all participants: (1) a Questionnaire regarding the socio-demographic/general health characteristics of the patient, (2) Impact of Event Scale-Revised, (3) Beck's Depression Inventory, (4) State-Trait Anxiety Inventory -1, (5) State-Trait Anxiety Inventory-2.
RESULTS: Post-traumatic stress disorder was detected in 129 (36.6%) infertile women. In cases of diminished ovarian reserve and oocyte freezing; a significantly higher incidence of post-traumatic stress disorder was found compared to patients with unexplained infertility, polycystic ovary syndrome, and male factor infertility (p=0.004). Minimal-mild depression level was detected in 295 (83.8%) participants, and moderate-severe depression level was found in 57 (16.2%) participants. The mean State-Trait Anxiety Inventory-1 and State-Trait Anxiety Inventory-2 scores of infertile women were 43.5±6.7 and 46.6±6.3, respectively. A statistically significant relationship was found between the duration of infertility and moderate-severe anxiety according to State-Trait Anxiety Inventory-1 (p=0.046).
CONCLUSION: Our findings show that women with long-term infertility and undergoing oocyte freezing are the most affected patients by the pandemic. It would be appropriate for in vitro fertilization centers to provide psychological support to patients that have a mentally high risk of distress.
Türkiye’de Üstün/Özel Yetenekliler Eğitiminde Öğretmen Yetiştirme Politikalarının Değerlendirilmesi: Bir Doküman İncelemesi Çalışması
Authors: KIR Sevda , ÖZDEMİR Murat
Published: September 2022

Bu araştırmanın amacı, uluslararası ve ulusal politika belgelerinin ışığındaülkemizdeki üstün/özel yetenekliler eğitiminde öğretmen yetiştirme politikalarınıdeğerlendirmektir. Çalışma, nitel araştırma olarak biçimlendirilmiş olup veritoplama aracı olarak ulusal politika belgeleri kullanılmıştır. Veriler dokümananalizi yöntemiyle toplanmıştır. Eğitim politikası, üstün/özel yeteneklilereğitimi, üstün/özel yetenekliler öğretmen yetiştirme, seçimleri ve buöğretmenlerin mesleki gelişimleri bağlamında belgeler analiz edilmiştir. Genelolarak politika belgelerinde son dönemlerde üstün/özel yetenekliler eğitiminedaha fazla yer verildiği göze çarpmaktadır. Alınan kararların çoğununuygulamaya geçirilemediği görülmektedir. Öğretmenlerin hizmet öncesindeüstün/özel yetenekliler eğitimiyle ilgili yeterli eğitimi almadıkları, üstün/özelyeteneklilerle ilgili eğitimlerin çoğunlukla BİLSEM öğretmenlerine yönelikolduğu ve örgün eğitim kurumlarındaki öğretmenlerin eğitim ihtiyaçlarının gözardı edildiği, hizmet içi eğitimlerin yetersiz olduğu, öğretmenlerin bu alandaeğitim ihtiyaçlarının olduğu anlaşılmaktadır. Ülkemizde üstün/özel yeteneklilereğitimi alanındaki öğretmen yetiştirme, seçme ve mesleki gelişimlerine yönelikpolitikalarda olumlu adımlar atılsa da henüz istikrarlı bir politikanınoluşturulamadığı anlaşılmaktadır. Çalışmada elde edilen bulgular ve sonuçlaragöre çeşitli önerilerde bulunulmuştur.
Batıya Doğru Akan Nehir İsimli Belgeselin Sosyal Bilgiler Dersi Öğretim Programı Kazanımları Açısından Değerlendirilmesi
Authors: VAR Ayşe , ORTAK Şaban , UTKUGÜN Ceren
Published: September 2022

Bu araştırmanın amacı; kapsamlı bir içeriğe sahip olan Batıya Doğru Akan Nehirbelgeselinin Sosyal Bilgiler Öğretim Programında yer alan kazanımlar açısındanincelenerek Sosyal Bilgiler derslerinde kullanılabilirliğini belirlemektir.Araştırma nitel araştırma yöntemlerinden doküman analizi yöntemine göreyapılandırılmıştır. Araştırmanın çalışma grubu Batıya Doğru Akan Nehir belgeselve 2018 tarihli Sosyal Bilgiler Dersi Öğretim Programından oluşmaktadır.Araştırma verilerinin toplanmasında hem araştırma modeli hem de veri toplamaaracı olarak değerlendirilen doküman analizi yöntemi kullanılmış, elde edilenverilerin analizinde betimsel analizden yararlanılmış, belgesel bölümlerindenyapılan doğrudan alıntılar ve ilişkilendirilen kazanımlar şeklinde sunulmuştur.Araştırma sonucunda; belgesel bölümlerinin toplamda 29 farklı kazanımlailişkilendirilebileceği, 49 farklı yerde Kültür ve Miras öğrenme alanıilişkilendirilebileceği ve en fazla ilişkilendirmenin 6. Sınıf Sosyal Bilgiler dersindeolduğu tespit edilmiştir. Belgeselin konu akışı Sosyal Bilgiler ÖğretimProgramında yer alan konularla paralellik gösterdiği için 5, 6. ve 7. sınıfseviyelerinde kullanılabilir olduğu ve Sosyal Bilgiler Ders Kitabı içeriğiyleparalel olduğu görülmüştür.
Akran Öğretiminin İşitme Kayıplı Öğrencilerin Kesirler Konusundaki Akademik Başarılarına Etkisi ve Öğrenci Görüşleri
Authors: ADA Seray Elçin , GÜLER SELEK Hatice Kübra , EZENTAŞ Ridvan
Published: September 2022

Bu çalışma, akran öğretiminin kesirler konusunun öğretiminde işitme kayıplısekizinci sınıf öğrencilerinin akademik başarılarına olan etkisini ve işitme kayıplıöğrencilerin akran öğretimi sürecine ilişkin görüşlerini ortaya koymayıamaçlamaktadır. Çalışmada ön test-son test kontrol gruplu yarı-deneysel desenkullanılmıştır. İstanbul ilindeki bir işitme engelliler devlet ortaokulunda sekizincisınıfa devam eden 12 öğrenci ile 8 hafta boyunca yürütülmüştür. Deneygrubundaki işitme kayıplı 6 öğrenciye akran öğretimi yöntemi ile kontrolgrubundaki işitme kayıplı 6 öğrenci ile geleneksel yöntemlerle öğretimyapılmıştır. Çalışmaya katılan tüm öğrencilere Kesirler Başarı Testi ön ve son testolarak uygulanmıştır. Ardından, deney grubundaki öğrencilerle yarıyapılandırılmış görüşmeler gerçekleştirilerek akran öğretimi ile ilgili sorularyöneltilmiştir. Öğrencilerin yanıtları içerik analizi yöntemiyle analiz edilmiştir.Çalışma sonucunda, kesirler konusunda akran öğretim yönteminin kullanılmasıöğrencilerinin akademik başarılarını istatistiksel olarak anlamlı şekilde artırdığıgözlemlenmiştir. Yapılan görüşmelerde öğrenciler, akran öğretimi yönteminifaydalı ve eğlenceli bulduklarını, eski bilgilerini hatırladıklarını ve konuyu dahaiyi öğrendiklerini ve akran öğretimini tekrarlama isteğinde olduklarınıbelirtmişlerdir
Vulnerabilidade de refugiados venezuelanos durante a pandemia: atuação de organizações da sociedade civil
Authors: de Araújo Oliveira Pedro Carlos
Published: September 2022

It deals with the development of actions in favor of Venezuelan refugees by civil society organizations during the coronavirus pandemic in Brazil. It aims to identify how civil society develops actions to ensure a core of minimum survival conditions for Venezuelan refugees.The method of qualitative and exploratory analysis was adopted, in which bibliographic and doc-umentary sources are used. The research was devel-oped with the aim of describing the condition of vul-nerability that the refugee experiences; then, the im-pacts that the pandemic caused on Venezuelan refu-gees and the state action in the development of pub-lic policies are demonstrated; Finally, the role of civil society organizations in the elaboration of strategies so that refugees could have access to food, housing, emotional support and defense of rights was dis-cussed. It is concluded that the participation of civil society in the elaboration of actions was fundamental to support Venezuelan refugees during the corona-virus pandemic. Refugees make up a group of vulner-able people and face great difficulties in accessing health care and in realizing their rights; associated with these conditions, the lockdown directly affected the lives of these people who saw their income re-duce and had difficulties accessing public services and benefits.
O direito de resistência e o controle do poder: uma necessidade “medieval”
Authors: Passos Maia Raquel , Passos Maia Aline
Published: September 2022

The transition from the Late Middle Ages to the Mo-dern Age was a turbulent period: conflicts, the Refor-mation, the rise of royal power to the detriment of the feudal system, all of this contributed to the secu-larization of political thought. It was a period marked by the publication of several papers, many of them in pamphlet nature, aimed at publicizing the abuses and convincing new adepts. After the episode in the city of Paris, known as Saint Bartholomew's Night, in 1572, the direction of thesewritings was changed and the construction of a theory of the right to resist ba-sed on political-legal foundations, in addition to reli-gious foundations, became a pressing need. This time, the present research aims to analyze the politi-cal and legal foundations of the right of resistance de-veloped by the huguenots —french calvinists —veri-fied at the end of the Low Middle Ages and at the be-ginning of the Modern Age in order to conclude for the need to control of the power and the role of re-sistance in the fight against abuse. Therefore, the ob-jective of the research is exploratory and descriptive, using the historical analysis and the bibliographic sur-vey of secondary sources.
O dilema do negociador e o acesso à justiça na mediação com a Fundação Renova: implicações ao processo indenizatório pelo rompimento da Barragem de Fundão e o modelo de claims resolution facilities como abordagem para o manejo de conflitos
Authors: Lima de Lucena Filho Humberto , Bastos Mesquita Minora de Almeida Ygor
Published: September 2022

The collapse of the Fundão dam is one of the greatest socio-environmental calamities. In order tospeed up the repair and compensation process, the Fundação Renova was created, an entity resposible for the Me-diated Indemnity Program (MIP), designed to deter-mining the amounts to be paid. Faced with the ex-posed situation, this paper analyzes the obstacles of the negotiator's dilemma to access to justice, through mediation, based on the adversities found in MIP. From the gathered elements, stands out that, despite presenting itself as a win-win approach, the MIP, by not incorporating the pricipled negotiation and by the effect of the negotiator's dilemma, culminating in agreements unfavorable to Renova and those im-pacted, an issue that, if not addressed, can be repro-duced in other claims resolution facilities. As a mech-anism to reverse this result, it is proposed to expand mediation, making it in charge of coordinating all communication with parties and eligibility to MIP, promoting, at the same time, relationship between the foundation and those affected, with the condi-tions for a mutual gains procedure.
Perspectivas de (não) soberania em Michel Foucault: da sociedade disciplinar às técnicas de governo pastoral
Authors: Rosa Alex
Published: September 2022

The present study aims to analyze the insufficiency of a juridical-sovereign model as a way of analyzing con-temporary power relations. Oriented by the archaeo-logical method, the research presents as a hypothesis the insufficiency of the models of legal-sovereign analysis to understand the dynamics of power, con-sidering that these have their best functioning from a microphysics of power. To this end, a bibliographic re-view of Michel Foucault's vast work constitutes the base material for research. In the itinerary proposed by this study, the theme will be addressed at first with the characterization of the microphysics of power, followed by a reading of the transition from the an-cien regimento the so-called disciplinary society -as-sociated with the biopolitical device -and ending in the techniques of consciousness direction, in pastoral power, that is, in the dimension of subjectivity that becomes the focus of relations between government and governed, explaining the difference that consti-tutes the modern government / population paradigm in face of the legal analyzes organized by the idea of sovereign / people.
O processo de institucionalização da infância preta em casas de acolhimento
Authors: Galoni Luana Luiza , Arcanjo Apóstolo da Silva Karoline , Ribas de Oliveira Grazielly , De Azevedo Peixoto Ana Cláudia
Published: September 2022

Neste artigo são discutidos os conceitos de território, territorialidade, raça e institucionalização, problematizando as relações que podem guardar entre si. Para tanto, parte-se do histórico do acolhimento institucional e seus atravessamentos com a raça negra, desde o Brasil colônia até aos dias atuais. Mostra-se como as casas de acolhimento têm se configurado como um território definido e delimitado por e a partir das relações de poder, gerando subjetividades e impregnando imaginário social até os dias atuais. Critica-se os mecanismos sociais que perpetuam as desigualdades sociais, apontando a negligência como uma forma concreta a prática de criminalização da pobreza. Expõe-se como as políticas públicas para a proteção de crianças e adolescentes precisam estar alinhadas com as questões raciais e socais, uma vez que preconiza-se o território como importante para a promoção das identidades, e essas são importantes para o desenvolvimento de subjetividade que combate a segregação racial e o racismo.
Tecnologias digitais como mediadoras da aprendizagem nas séries iniciais
Authors: Silva Danubia Cauana Zarur da , Santos Lielta Cardozo dos , Rauta Marineide Pereira , Nepomoceno Taiane Aparecida Ribeiro
Published: September 2022

O objetivo deste artigo foi descrever os aspectos do uso das tecnologias digitais nas séries iniciais, do ensino fundamental I. Para tanto foi utilizada a metodologia de pesquisa qualitativa, de caráter exploratório e desenvolvida a partir da técnica de revisão de literatura narrativa de artigos científicos. Para a coleta de materiais foram consultadas duas bases de dados, a citar: Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Google Scholar. Foram incluídos apenas artigos científicos publicados em periódicos, a partir de 2015 e em língua portuguesa. Os cinco artigos analisados são coerentes as afirmar que as tecnologias digitais são recursos facilitadores da prática docente, trazendo inovação para as aulas e melhorias, especialmente, nas abordagens dos conteúdos curriculares. Assim, as tecnologias digitais, podem ser entendidas como ferramentas didáticas, intermediadoras nos processos de ensino e aprendizagem, na abordagem, aperfeiçoamento de conteúdos curriculares das séries iniciais e no desenvolvimento de um sistema educativo moderno, contudo precisam de subsídios públicos, formativos e técnicos.
Perfil Epidemiológico da Tuberculose no Estado de Pernambuco nos Últimos Dez Anos
Authors: Gomes da Silva Wenys Claudio , Chaves Amanda Maria , Júnior Irani de Farias Cunha
Published: September 2022

RESUMO

Apesar da transição no perfil epidemiológico, a tuberculose ainda continua como um sério entrave à saúde pública em todo mundo. No Brasil, o estado de Pernambuco está entre as capitais que possuem um coeficiente de mortalidade por essa doença maior do que o coeficiente do país. O trabalho tem como objetivo estabelecer o perfil epidemiológico da doença Tuberculose no estado de Pernambuco nos últimos 10 anos. O presente estudo se caracteriza por ser Ecológico Retrospectivo, utilizado para medir a prevalência de doenças e útil para o planejamento em saúde. A coleta de dados foi realizada de forma secundária através da divisão de Tuberculose - Casos confirmados e notificados no Sistema de Informação de agravos de notificação – Pernambuco no TABWIN-PE. O número de casos através dos anos aparece alto e constante, sendo o ano de 2019 o que alcançou mais casos, com um total de 6.166, o que representa um aumento de 11,8% ao ano com menos casos que foi 2010. Foi observado que o Perfil Pernambucano nos últimos 10 anos foi análogo ao de diversos estudos e também se esclareceu a importância de medidas de prevenção focadas nas populações encontradas. O alto índice de novos diagnósticos pela tuberculose em Pernambuco, durante os anos de 2010 a 2019, mostra transparência no Sistema de Notificação, visto que a subnotificação é um fator apontado por vários autores.

PALAVRAS-CHAVE: Tuberculose, Saúde Coletiva, Epidemiologia.
Análise epidemiológica dos procedimentos cirúrgicos por transplante de células-tronco hematopoiéticas de medula óssea: autogênico versus alogênico
Authors: Cristine da Silva Sant'Ana Isabella , Cezário Costa Reis Bruno
Published: September 2022

Os transplantes de medula óssea, são uma modalidade terapêutica que permite a utilização de altas doses de quimioterápicos, devido a possibilidade da infusão de células tronco hematopoiéticas, para reverter a toxicidade causada pelas drogas utilizadas na quimioterapia. O objetivo do presente estudo é a analisar e comparar o perfil epidemiológico dos procedimentos cirúrgicos de transplante autogênico de células tronco hematopoiéticas de medula óssea com o transplante alogênico aparentado e não aparentado. Trata-se de um estudo observacional, descritivo e transversal dos dados disponíveis no DATASUS de dezembro de 2014 a dezembro de 2019, avaliando o número de internações e taxa de mortalidade do transplante autogênico de células-tronco hematopoiéticas de medula óssea, do transplante alogênico de células-tronco hematopoiéticas de medula óssea aparentado e do transplante alogênico de células-tronco hematopoiéticas de medula óssea não aparentado. No Brasil, no período analisado ocorreram 1019 internações para o procedimento de transplante autogênico de células-tronco hematopoiéticas de medula óssea, 1683 internações para o transplante alogênico de células-tronco hematopoiéticas aparentado e 833 internações para o transplante alogênico de células-tronco hematopoiéticas não aparentado. Tal coleta contribuiu para abordar os pontos positivos e negativos das duas modalidades de transplante de medula-óssea. Sendo observado que o procedimento feito com células do próprio paciente, apresenta menos riscos do que o feito com células de outro doador, entretanto, por ter muitos requisitos para o procedimento, o transplante autólogo é mais realizado no Brasil do que o autogênico.
Efeitos da Colostroterapia no Aumento da Imunidade em Prematuros
Authors: Alvarenga Gisele , Bhering Carlos Alberto
Published: September 2022

Dado o pior prognóstico dos prematuros, uma nova estratégia tem sido estudada para manter a saúde dos recém-nascidos pré-termo, sobretudo daqueles com muito baixo-peso (peso de nascimento < 1500 gramas), conhecida como colostroterapia ou administração orofaríngea de colostro materno, que trata da utilização do colostro materno cru como terapia imune, sem função nutricional, para recém-nascidos prematuros e/ou de muito baixo-peso. A técnica consiste na administração de 0,2 mililitro de colostro materno (0,1 ml em cada lado da cavidade oral), na frequência de três em três horas, por cinco dias consecutivos, iniciando entre 24 e 96 horas de vida da criança. O objetivo deste trabalho foi realizar uma revisão sistemática sobre os efeitos da colostroterapia no aumento da imunidade em prematuros. Este estudo trata-se de uma revisão sistemática da literatura através de um levantamento bibliográfico onde foi utilizado como fonte de pesquisa o acervo de dados da National Library of Medicine (PUBMED). Após o levantamento dos artigos através dos bancos de dados e seguindo os critérios de inclusão pré-estabelecidos, obtivemos um total de 28 estudos. A colostroterapia parece ser benéfica para bebês extremamente prematuros; no entanto, a segurança e eficácia não foram estabelecidas. Embora as evidências emergentes sejam promissoras, pequenas amostras e ampla variação na técnica limitam a generalização.