bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnóstico do bruxismo infantil: uma revisão da literatura para auxiliar o cirurgião-dentista
Authors: Siqueira Laura Simões , Machado Carina Borges , Ripplinger Tamara , Da Costa Catiara Terra
Published: June 2021

Objetivo: analisar a literatura pertinente sobre diagnóstico do bruxismo infantil, a fim de auxiliar o cirurgião-dentista em como detectar esta condição. Materiais e métodos: através das bases de dados PubMed, SciELO e Lilacs, com termos específicos, foi revisada a literatura e realizada a seleção de artigos mais relevantes, por dois examinadores independentes. Os critérios incluíram crianças com bruxismo, de 0 a 12 anos, independentemente de sexo, ano ou contexto geográfico. Resultados: inicialmente, 1.409 artigos foram identificados. Após a exclusão de duplicatas, avaliação dos títulos, resumos e textos completos, foram selecionados 42 artigos. Uma tabela foi delineada para extrair dados e através desta foram mapeados os estudos. Questionários/ relatos dos responsáveis foram os métodos mais utilizados para diagnóstico de bruxismo infantil, relatados na literatura, 21 artigos, e associados com exame clínico, 16 artigos. A polissonografia foi utilizada em 5 artigos, sendo 2 exclusivamente, 1 em revisão sistemática e 2 associados com questionário aos responsáveis. Os indicadores da Associação Americana de Medicina do Sono (AASM) foram utilizados em 9 artigos. Conclusão: a associação entre exame clínico/relato dos responsáveis, com critérios específicos, sugere uma boa conduta para o cirurgião-dentista, embora a polissonografia seja considerada o método padrão-ouro, pois independe de condições financeiras e manejo, principalmente por se tratar de crianças.
Los índices bursátiles: relevancia del Dow Jones, S&P 500 y Nasdaq en la economía
Authors: Palma Canales Marcel
Published: June 2021

Los índices de los mercados financieros reflejan el devenir de la economía y principalmente en los mercados en donde estos se encuentran desarrollados, es común observar en las noticias económicas las perspectivas y el comportamiento de estos índices, por lo tanto, es importante conocer y ahondar sobre su correspondiente funcionamiento. El estudio se basa en un análisis descriptivo utilizando la síntesis y recopilando datos de fuentes secundarias para establecer los hechos de la funcionalidad de estas herramientas bursátiles y cómo ha evolucionado la cotización de estos mercados. Se aborda la cotización de estos índices en una periodicidad del año 2000 al año 2020 con el uso del análisis técnico a través de indicadores y análisis de gráficos. Es el objetivo de este estudio en primera instancia definir algunos conceptos relevantes sobre los índices bursátiles, posteriormente se explica la historia del índice de Dow Jones, la Teoría de Dow y su similitud con la Teoría de Robert Elliot, se analiza el comportamiento y evolución del mercado. Se desarrolla un análisis sobre el índice S&P 500 explicando cómo se conforma y elabora además del comportamiento y evolución. Por último, se describe el Nasdaq 100, cómo este índice tecnológico se desarrolla, reflejando los vaivenes de la economía de EE. UU. y como se ve afectado por eventos internacionales.
Gestão da informação, comunicação científica e internacionalização
Authors: Araújo Paula Carina de , Freitas Maria Do Carmo Duarte , Lanz Helza Ricarte
Published: June 2021

Apresenta o fasciculo v.10, n.2 de maio/ago. de 2021 da Revista AtoZ.
Supplementation of Pandanus conoideus Oil in Cryopreservation Diluents for Maintaining the Semen Quality of Ongole Grade Bull
Authors: Nurcholis Nurcholis , Furqon A. , Arifiantini R. I. , Salamony S. M.
Published: June 2021

Antioxidants such as tocopherol, ß-carotene, and polyunsaturated fatty acids (PUFA) from red fruit oil of Papua may be used to protect frozen semen. The study is aimed to test the effect of red fruit oil supplementation on motility, viability, and recovery rate of frozen sperm of Ongole-grade bulls. Semen was collected twice a month from eight 4-5-year-old male Ongole grade using an artificial vagina, followed by macro- and microscopical evaluations. Collected semen was divided into four tubes and diluted with tris egg yolk diluents (TEY) as a control, TEY supplemented with 0.5% red fruit oil (RFO) (TEY RFO0.5), TEY supplemented with 1% RFO (TEY RFO1.0), and TEY supplemented with 1.5% RFO (TEY RFO1.5). The diluted semen was then packed into the straw and equilibrated for 2, 4, and 6 h prior to frozen on liquid nitrogen vapor for 10 minutes. The observed variables in this study were sperm motility, sperm viability, and morphology after equilibration, after thawing, and recovery rate. The experimental design is a completely randomized factorial design. The data were analyzed using ANOVA and were further tested using Duncan multiple range test. The results showed that the sperm motility of fresh semen was 81.10±1.42%. The percentage of sperm motility in TEY RFO1.5 treatment at 6 h equilibration was 60.00±1.06%, significantly higher compared to TEY RFO1.0 and TEY RFO0.5. The percentage of post-thawing sperm motility in TEY RFO1.5 treatment was 62.40±1.09%. The best post-thawing sperm viability in TEY RFO1.5 was 80.70±1.20%, significantly increase from the treatment of TEY RFO1.0 and TEY RFO0.5. The recovery rate (RR) for TEY RFO1.5 treatment had the best percentage at 76.94%. In conclusion, RFO supplementation in semen diluents for 2 h of equilibration resulted in the best motility and viability at 0 h of post thawing observation.
Extraction of Collagen from the Skin of Kacang Goat and Production of Its Hydrolysate as an Inhibitor of Angiotensin Converting Enzyme
Authors: Hakim T. R. , Pratiwi A. , Jamhari Jamhari , Fitriyanto N. A. , Rusman Rusman , Abidin M. Z. , Matulessy D. N. , Erwanto Y.
Published: June 2021

The study was designed to determine the potential of collagen hydrolysate produced from the skin of Kacang goat through chymotrypsin hydrolysis to be used as an inhibitor of angiotensin converting enzyme (ACE). This research was conducted in three replications, with the measured parameters include ACE inhibitory potential and collagen hydrolysate fractionation. The results showed that collagen extraction of Kacang goat skin by chymotrypsin hydrolysis yielded 9.74% (dry matter, v/v) collagen, with pH at 6.6. The extracted collagen contained α1, α2, and β collagen chains with molecular weights of 151 kDa, 141 kDa, and 240 kDa, respectively. Furthermore, the collagen hydrolysis produced protein peptides confirmed at molecular weights of 43 to 107 kDa. The hydrolysate fractionation at molecular weights of <3 kDa, 3-5 kDa, and >5 kDa showed proteins concentrations of 2.33 mg/mL, 3.81 mg/mL, and 3.93 mg/mL, respectively. The hydrolysate fractionation with molecular weight <3 kDa showed to have ACE inhibition activity with the IC50 value of 0.47 mg/mL. The study concluded that collagen hydrolysate extracted from the skin of Kacang goat had a promising potential as a source of antihypertensive agent.
Two-dimensional mesh generator and quality analysis of elements on the curvilinear coordinates system
Authors: Naozuka Gustavo Taiji , Romeiro Neyva Maria Lopes , Felinto Alan Salvany , Natti Paulo Laerte , Cirilo Eliandro Rodrigues
Published: June 2021

Through mathematical models, it is possible to turn a problem of the physical domain to the computational domain. In this context, the paper presents a two-dimensional mesh generator in generalized coordinates, which uses the parametric linear spline method and partial differential equations. The generator is automated and able to treat real complex domains and, consequently, more realistic problems. However, there is a possibility that lower quality elements may be introduced into the computational mesh. Thus, metrics are investigated that identify elements considered to be of lower quality. Experiments are carried out to verify the efficiency of the adopted metrics, considering meshes with single block, and multi-blocks. According to the experiments, the work allowed the detection of elements of lower quality, contributing to the realization of an adequate modeling of geometries
Cooperate or Compete? Insights from Simulating a Global Oil Market with No Residual Supplier
Authors: Rioux Bertrand , Jarboua Abdullah Al , Karanfil Fatih , Pierru Axel , Rashed Shahd Al , Ward Colin
Published: June 2021

Structural changes in the oil market, such as the rise of tight oil, are impacting conventional market dynamics and incentives for producers to cooperate. What if OPEC stopped organizing residual production collectively? We develop an equilibrium model to simulate a competitive world oil market from 2020 to 2030.It includes detailed conventional and unconventional oil supplies and financial investment constraints. Our competitive market scenarios indicate that oil prices first decline and tend to recover to reference residual supplier scenario levels by 2030. In a competitive oil market, a reduction in the financial resources made available to the global upstream oil sector leads to increased revenues for low-cost producers such as Saudi Arabia. Compared to the competitive scenario, Saudi Arabia does not benefit from acting alone as a residual supplier, but, under some assumptions, it benefits from being part of a larger group that works collectively as a residual supplier.
The effect of financial, macroeconomic and sentimental factors on stock market volatility
Authors: Czapkiewicz Anna , Choczyńska Agnieszka
Published: June 2021

The aim of this paper is to find economic factors that could be helpful in explaining the market’s shifts between periods of prosperity and crisis. The study took into account the main stock indices from developed markets of the USA, Germany and Great Britain, and from two emerging markets, i.e. Poland and Turkey. The analysis confirms the existence of two different states of volatility in these markets, namely the state with a positive returns’ mean and low volatility, and the state with a negative or insignificant mean and high volatility. The Markov-switching model with a dynamic probability matrix was applied in the study. The subject of the analysis was the impact of domestic and global factors, such as VIX and TED spread, oil prices, sentiment indices (ZEW), and macroeconomic indices (unemployment, longterm interest rate, CPI), on the probability of switching between the states. The authors concluded that in all the examined countries, changes in long-term interest rates have an influence on market returns. However, the direction of this impact is different for developed and emerging markets. As regards developed markets, high prices of oil, 10-year bonds, and the ZEW index can suggest a high probability of the countries remaining in the first state, whereas an increase in the VIX index and the TED spread significantly reduces the probability of staying in this state. The other studied factors proved to be rather local in nature.
Skutki hamowania funkcji PCSK9 w obrębie wybranych tkanek*
Authors: Maligłówka Mateusz , Bułdak Łukasz , Okopień Bogusław , Bołdys Aleksandra
Published: June 2021

Streszczenie

Konwertazy probiałkowe (PCs, proprotein convertases) to rodzina 9 proteaz serynowych (PC1/3, PC2, furyna, PC4, PC5/6, PACE4, PC7, SKI-1), której przedstawicielem jest również konwertaza probiałkowa typu 9 o aktywności subtylizyny/keksyny (PCSK9). Poszczególni członkowie tej rodziny, są głównym elementem w potranslacyjnej obróbce białek prekursorowych, prowadzącej do powstania biologicznie czynnych cząsteczek, takich jak hormony, enzymy, czynniki transkrypcyjne oraz czynniki wzrostu. W związku ze zdolnością aktywacji dużej liczby substratów, PCs odgrywają znaczącą rolę w przebiegu procesów fizjologicznych, takich jak embriogeneza, aktywność ośrodkowego układu nerwowego, metabolizm lipidów, a także w stanach patofizjologicznych m.in. infekcjach wirusowych i bakteryjnych, osteoporozie, hiperglikemii, chorobach sercowo-naczyniowych, neurodegeneracyjnych oraz nowotworowych. Zahamowanie funkcji konwertazy proproteiny typu 9 o aktywności subtylizyny/keksyny (PCSK9, proprotein convertase subtilisin/kexin 9) przez przeciwciała, takie jak alirokumab czy ewolokumab zmniejsza tempo degradacji receptora LDL (lipoproteina o małej gęstości). Wiąże się to z redukcją stężenia cholesterolu LDL w osoczu, którego normalizacja jest jednym z głównych celów służących ograniczeniu ryzyka sercowo-naczyniowego. Inhibitory PCSK9 (alirokumab, ewolokumab, bococizumab) zostały stworzone m.in. z myślą o pacjentach, u których mimo stosowania optymalnych dawek dostępnych leków hipolipemizujących (statyn, ezetymibu) nie udało się uzyskać pożądanych wartości stężeń cholesterolu LDL we krwi. Wydaje się, że ze względu na dużą skuteczność, przyszłe zastosowanie inhibitorów PCSK9 (PCSK9i) w codziennej praktyce klinicznej będzie bardziej powszechne. Uwzględniając działania plejotropowe substancji dotychczas stosowanych w hiperlipidemii, takich jak statyny, omówiono piśmiennictwo pod kątem innych, poza hipolipemizującymi, możliwych skutków działania inhibitorów PCSK9 oraz oceniono ich potencjalne zalety lub wady.
Efetivação do uso de Tecnologias na Educação: Desafios na formação de recursos humanos
Authors: Vieira Márcia
Published: June 2021

Este trabalho objetiva contribuir diretamente com as discussões referentes à formação de recursos humanos para a utilização das Tecnologias da Informação e Comunicação na educação. De cunho essencialmente bibliográfico, considera como principais fontes de pesquisa relatos científicos de experiências sobre a aplicação da TIC na educação escolar. Com base nos relatos estudados, ratifica a necessidade de desenvolvimento de competências docentes para uso das TIC numa visão crítica e contextualizada e propõe algumas alternativas para a formação docente para que as tecnologias sejam efetivamente incorporadas nas práticas pedagógicas dos professores.
Treatment with Grazoprevir/Elbasvir in Post-kidney Transplant Patients with Hepatitis C Virus Genotype 4 Infection
Authors: Abaalkhail Faisal , Al-hamoudi Waleed , Altraif Ibrahim , Mohamed Hazem , Aleid Hassan , Broering Dieter , Alqahtani Saleh
Published: June 2021

Background: Kidney transplant (KT) recipients have a high rate of hepatitis C virus (HCV) infection, which can impact long-term graft and patient survival rates. Although direct-acting antivirals (DAAs) are effective for treating HCV, there is limited data on their use in post-KT patients with HCV genotype 4 infection. Objectives: To evaluate the effectiveness and occurrence of adverse events with grazoprevir/elbasvir combination treatment without ribavirin in post-KT patients with HCV genotype 4 infection. Methods: In this case series, nine therapy-naïve adult post-KT patients with HCV genotype 4 infection were recruited. They had stable graft function and received a fixed dose of grazoprevir/elbasvir (50 mg/100 mg) combination without ribavirin daily for 12 weeks. Patients co-infected with hepatitis B virus, HIV, or with evidence of decompensated liver disease were excluded from the study. Patients were monitored for viral load, laboratory values, and adverse events associated with drug treatment. The response was defined by the sustained virologic response at 12 weeks (SVR12) after the end of treatment. Results: All nine patients completed the treatment period and achieved SVR12 with no treatment failure or relapse. Of them, six patients had HCV genotype 4 infection alone, and three had HCV of mixed genotypes 1 and 4. Two (22%) patients showed a rapid HCV clearance at four weeks. No adverse events or serious adverse events were reported. The patients’ renal function was stable during and after the treatment with no deterioration of graft function, and no adjustments to the immunosuppressive therapy were required. Conclusions: Grazoprevir/elbasvir combination without ribavirin is an effective and safe treatment option for post-KT patients with genotype 4 HCV infection.
Comparison of Color Doppler Imaging Criteria for the Ophthalmic Artery and Central Retinal Artery in Infants with Retinopathy of Prematurity with and Without Plus Disease
Authors: Soleimani Marzieh , Ghetmiri Seyed Ehsan , Ahrar Yazdi Mohammad Hossein
Published: June 2021

Background: Color Doppler imaging (CDI) is a non-aggressive and safe technique for the clinical management of retinal diseases. Recently, the number of infants with retinopathy of prematurity (ROP) has increased due to the incidence of premature births. Objectives: This study aimed to compare the CDI criteria for the ophthalmic artery (OA) and central retinal artery (CRA) in ROP infants with and without plus disease. Patients and Methods: In this case-control study, 42 premature infants (21 infants with plus disease and 21 infants without plus disease) underwent CDI. The arterial CDI parameters, including end-diastolic velocity (EDV), pulsatility index (PI), resistance index (RI), and peak systolic velocity (PSV), were measured in these patients. After collecting the data, t-test and chi-square tests were used for data analysis. P < 0.05 was considered to be statistically significant. Results: The mean EDV of CRA in patients with and without plus disease was 4.35 ± 1.00 and 5.27 ± 1.02 cm/sec, respectively (P = 0.005). The mean PSV of CRA in patients with and without plus disease was 15.65 ± 3.35 and 18.39 ± 4.39 cm/sec, respectively (P = 0.029). However, no significant difference was found between the two groups in terms of PSV or EDV of OA (P > 0.05). Also, no significant difference was observed between the two groups considering the RI and PI of CRA and OA (P > 0.05). Conclusion: According to the findings of this study, CDI criteria, such as EDV and PSV of CRA, were significantly lower in infants with plus disease as compared to those without plus disease. Since detecting the early stages of plus disease is a challenge for ophthalmologists, assessment of these criteria can be helpful for differentiation of these two subgroups of patients. However, further studies with a larger sample size are needed to determine the cutoff value.
Investigation of Mutations in the Rifampin-Resistance-Determining Region of the rpoB Gene of Brucella melitensis by Gene Analysis
Authors: Dadar Maryam , Bazrgari Nasim , Garosi Ghasem Ali , Hassan Sameer
Published: June 2021

Background: RNA polymerase beta subunit (rpoB) gene analysis in bacterial communities is known as a method for determining rifampin sensitivity and genetic diversity among Brucella spp. Detection of antibiotic resistance among Brucella isolates can be a critical approach to control brucellosis. However, rpoB gene analysis of Brucella melitensis for assessing rifampicin resistance has not yet been performed in Iran, which is considered an endemic area for brucellosis. Objectives: The aim of this study was to analyze the whole sequence of rpoB genes of different B. melitensis isolates from humans to identify the single-nucleotide polymorphisms (SNPs) and mutations related to rifampin resistance and to analyze the genetic diversity of these bacteria in Iran. Methods: Between 2017 and 2019, a total of 156 blood samples along with 12 synovial fluid specimens were collected from brucellosis patients in different Iranian provinces and subjected to bacterial culture in Brucella selective media. Brucella identification was carried out using classical biotyping and molecular examinations. Polymerase chain reaction (PCR)-based amplification of the rpoB gene was performed by specific rpoB primers for whole gene sequencing. The antimicrobial susceptibility of Brucella isolates was assessed using disk diffusion susceptibility tests and minimal inhibitory concentration (MIC) methods. The presence of rifampin-binding sites and SNPs were investigated through rpoB whole gene sequencing. Results: Clinical B. melitensis isolates were obtained from blood (13) and synovial fluid (1) samples of patients from different regions of Iran. The results of MIC and disk diffusion susceptibility tests showed that all the isolates were sensitive to rifampin except for one isolate showing intermediate rifampin resistance based on the standards defined for slow-growing bacteria by the Clinical and Laboratory Standards Institute (CLSI). Gene analysis for identifying the mutations related to rifampin resistance and investigating genetic diversity showed that none of the B. melitensis isolates had missense mutations, confirming the susceptibility of all the studied isolates to rifampin. Conclusions: The present study revealed that rpoB gene analysis could be used for the efficient and precise identifying of the mutations related to rifampin resistance, investigating rifampin binding sites, and genotyping Brucella species. Furthermore, the identification of B. melitensis isolates with intermediate resistance to rifampicin highlighted the importance of periodically carrying out antibiotic susceptibility testing. The molecular detection of rpoB mutations in different Brucella isolates may help to prevent the spread of rifampin-resistant Brucella spp. among humans and livestock.
The Fertility Outcome of Royal Jelly versus Intra Uterine Insemination: A Pilot Randomized Controlled Trial Study
Authors: Fathi Najafi Tahereh , Khadem Nayereh , Bahri Narjes , Meshkat Mojtaba , Sadri Shirin , Dashti Sareh
Published: June 2021

Background: The popularity of complementary and alternative medicine is on the rise. Objectives: The current study aimed to compare the effect of vaginal royal jelly with intrauterine insemination (IUI) on sub-fertility in men. Methods: The sample size was estimated as 27 subjects, based on a study power and confidence interval of 80% and 95%, respectively. The study was conducted in Mashhad, in the Northeast of Iran, from 2015 to 2017. Men with sub-fertility (asthenozoospermia, defined as total sperm motility below 40% and sperm concentration below 20 million/mL), with healthy wives, based on salpingography, participated in this study. Patients were assigned to the royal jelly group, which received 5 grams of royal jelly, and the IUI group, which received 75 units of Follicle Stimulating Hormone (FSH) from the second day of the menstrual cycle. Semen samples were collected in sterile plastic caps after 72 hours of sexual abstinence by normal sexual intercourse. Samples were prepared using the standard swim-up technique. Results: This study showed no significant difference between groups concerning spousal age, occupation, education (husband and wife), and social class (P = 0.745). Also, no significant difference was found between groups concerning fertility success rate (P = 0.573). Conclusions: Based on similar treatment success rates of royal jelly and IUI, it seems that royal jelly can be considered as an alternative to IUI.
Scope and Challenges of Self-Directed Learning in Undergraduate Medical Education: A Systematic Review
Authors: Buch Archana Chirag , Rathod Hetal , Naik Mukta Durgesh
Published: June 2021

Context: Self-directed learning (SDL) is an individual’s ability to effectively use various strategies to reach his/her learning goals. We conducted this systematic review to explore the different methods, advantages, and challenges in SDL. Method: A systematic and comprehensive literature search on PubMed, Scopus, and Google Scholar databases was carried out using keywords such as “self-directed learning”, “self-regulated learning”, and “medical undergraduate curriculum” among articles published between 2010 and 2020. Original articles having methods, advantages, and challenges were included. The data were summarized and analyzed thematically. Results: Out of the total number of 1781 screened articles, sixteen eligible studies were included in the systematic review. Flipped classrooms, problem-based learning, case-based scenarios, video lectures, and e-learning were the commonly used methods. Self-assessment, time management, motivation, teamwork, and critical thinking were the advantages. Faculty guidance, time constraints, distraction due to technology, lack of organizational skills, and difficulty to learn complex topics were the common challenges of SDL. Conclusions: Most of the articles in recent years explain the growing interest in SDL in the medical curriculum. Despite numerous advantages of SDL, there are several challenges and limitations due to the lack of specific and defined guidelines for its implementation. Further research is required for structured methods and strategies for SDL effective implementation.
I Will Tell A Double Tale
Authors: Decker Jessica Elbert ,   Philosophy Documentation Center
Published: June 2021

Double speak refers to two parallel devices that are often deployed together: simple repetition, which is frequently used as both emphasis and as an indicator of double speak, and ambiguous syntax such that the phrase uttered may have multiple meanings at once. This paper explores the use of double speak in early Ancient Greek poetic texts, beginning with Homer and tracing its use through the texts of Heraclitus, Parmenides, and Empedocles. Double speak seems to be employed in order to mediate between mortal and divine, creating a double audience: a god or goddess is capable of speaking in two registers at once, so a mortal listening will infer one meaning, while from the perspective of the god or goddess speaking, the statement will have another meaning supplemental to the first. This paper demonstrates the manner in which these Presocratic thinkers employ double speak as a means of disrupting human binary habits of thinking and creating a “quantum awareness” where the subject is able to perceive the relationships and paradoxes that exist between the knower and the seeming objects of knowledge, as well as the habits of thinking and perceiving that nourish the repetition and growth of those patterns.
Interferência de Commelina benghalensis no crescimento inicial de Eucalyptus grandis no inverno e no verão
Authors: Costa Augusto Guerreiro Fontoura , Bacha Allan Lopes , Pires Rodrigo Neto , Pavani Maria do Carmo Morelli Damasceno , Alves Pedro Luis da Costa Aguiar
Published: June 2021

Plantas de eucalipto são sensíveis à interferência imposta pela comunidade infestante, principalmente durante o crescimento inicial, período que compreende o primeiro ano após a instalação da cultura. Sendo assim, o presente estudo objetivou avaliar o efeito de densidades crescentes de Commelina benghalensis L. (trapoeraba) sobre o crescimento inicial de plantas de Eucalyptus grandis Hill (ex Maiden) em duas estações do ano (inverno e verão). Foram realizados dois experimentos, um no inverno (durante 90 dias) e outro no verão (durante 120 dias), em área aberta, semicontrolada, em caixas de 70 L. Para ambos os experimentos utilizou-se delineamento em blocos casualizados, com quatro repetições e os tratamentos consistiram de densidades crescentes de trapoeraba: 0 (testemunha), 4, 8, 16, 20, 28, 36, 40, 60 e 80 plantas m-2. Quinze dias após o plantio das mudas de trapoeraba, foi plantada uma muda de eucalipto no centro de cada caixa. Ao final dos períodos experimentais, foram avaliados a altura, o diâmetro, a área foliar e a massa seca da parte aérea do eucalipto. Observou-se que a partir de 4 plantas m-2 já houve interferência negativa no crescimento do eucalipto, com reduções de 38,4% na área foliar e 35% na massa seca, no inverno; e reduções de 52,9% na área foliar e 64,7% na massa seca, no período de verão. Conclui-se que a partir da densidade de 4 plantas m-2 há interferência no crescimento do eucalipto e que, no período de verão, a planta daninha apresenta comportamento competitivo mais agressivo, causando maior interferência nas plantas de eucalipto.
Efeitos dos modelos econômicos nas políticas de distribuição de bens linguísticos no Brasil
Authors: Pietri Emerson de
Published: June 2021

Com o objetivo de contribuir para a compreensão dos processos de distribuição de bens linguísticos na sociedade brasileira, são observadas, neste trabalho, as mudanças que se operaram nas bases econômicas de produção capitalista, a partir da década de 1970, e os projetos políticos, sociais e educacionais definidos para o país em diferentes conjunturas históricas desde então constituídas. A não consideração mais detalhada das mudanças nas bases econômicas e de seus efeitos para a manutenção ou amplificação da desigualdade social dificulta a observação mais atenta do funcionamento, nessa ordem, dos projetos oficiais para o ensino de língua portuguesa no Brasil. Nesse sentido, são evidenciadas, com base em conceitos da análise do discurso de linha francesa, as tensões resultantes da concorrência entre modelos político-econômicos implantados no país, nas três últimas décadas do século XX e nas décadas iniciais do século XXI, e suas relações com a constituição de concepções concorrentes de língua e de sujeito da aprendizagem, estabelecidas, no período observado, em políticas públicas de educação e materializadas em documentos de parametrização curricular. Os resultados apontam para a necessidade de questionar os efeitos da implantação de um currículo nacional comum para o ensino de língua portuguesa quando são mantidas as condições desiguais de escolarização, em um contexto de destruição de políticas sociais e de fortalecimento das bases concorrenciais na ordem econômica do país, expandidas agora para as classes mais pobres.
Logística reversa como instrumento de sustentabilidade ambiental em uma escola pública
Authors: Santos André dos , Mesquita Aurea do Nascimento Siqueira , Caraciolo Mércia Cristina de Magalhães , Costa Valéria Sandra de Oliveira
Published: June 2021

A logística reversa é uma estratégia que operacionaliza o retorno de resíduos sólidos ao ambiente de negócios e produtivo. Promover esse trabalho em escolas é algo novo, já que a comunidade escolar e parte da sociedade desconhecem os malefícios que os componentes presentes em pilhas e baterias causam ao meio ambiente e à saúde humana. Este estudo objetivou promover a logística reversa de pilhas e baterias, através de ações realizadas com alunos na Escola de Referência em Ensino Médio Frei Epifânio, no estado de Pernambuco, assim como desenvolver práticas educativas para sensibilizar a comunidade escolar em relação ao descarte correto do lixo eletrônico. Tratou-se de um estudo de campo descritivo, com base quali-quantitativa, no qual foi aplicado um questionário aos professores e alunos do 1º ao 3º do ensino médio e da Educação de Jovens e Adultos. A partir das respostas obtidas os dados foram compilados e analisados e foram apresentados em uma tabela, utilizando a frequência relativa (FR). Os resultados apontam que a temática logística reversa, nessa escola, ainda não foi alvo de ações relacionadas à Educação Ambiental e que muito há de ser feito para poder despertar nos discentes, docentes e comunidade a mudança de hábitos e atitudes, principalmente, no descarte desses resíduos e práticas de Educação Ambiental. Nesse sentido, são ações de logística reversa como essa que muitas escolas deveriam fazer, pois podem contribuir não apenas para um meio mais equilibrado, mas também para o desenvolvimento de projetos de Educação Ambiental e escolas mais sustentáveis.
Memória do crochê
Authors: Mourão Nadja Maria , Oliveira Ana Célia Carneiro
Published: June 2021

Um objeto qualquer pode se tornar um objeto biográfico a partir da construção dos fatos, do tempo e do ambiente onde o mesmo foi inserido, em relação à vida humana. Compreender a importância das relações afetivas entre os seres humanos e os seus objetos biográficos do cotidiano, constitui-se o objetivo principal para o desenvolvimento deste trabalho. Inclusive, busca-se identificar a relevância das relações afetivas entre pessoas, por meio do fazer crochê e seus reflexos positivos para a memória coletiva. Esta pesquisa bibliográfica, qualitativa, de forma expositiva recria um contexto teórico. Por abordagens metodológicas do design social, utiliza estudos de artigos e demais produtos científicos. As relações afetivas que se instalam ente o ser humano e estes objetos também podem definir o tempo, o lugar, a história de vida de um indivíduo ou grupo social, enfim situar o território. O artesanato do crochê pode ser executado em grupo e, consequentemente, por dedicação do grupo, torna-se uma tradição. Observou-se que o crochê pode ser aplicado em qualquer objeto, desde que se utilize o potencial criativo e a pesquisa de materiais. Para atender ao trabalho coletivo, busca-se matéria-prima na região. Ele impulsiona o movimento de revalorização do “feito à mão”. Dessa forma, torna-se possível inserir as relações afetivas com os objetos, com os lugares e toda a história de vida de um indivíduo ou grupo social.
Relación entre la tecno-procrastinación y el rendimiento académico: un estudio del caso
Authors: Ramón García Cristina , Peinado Rocamora Pedro , Rodríguez Nieto María Elena
Published: June 2021

La gestión eficaz del tiempo es un aspecto esencial en los resultados académicos.  El uso del teléfono móvil y su influencia en la adecuada administración del tiempo del estudiante configura el núcleo de este trabajo. La hipótesis de partida presupone una equivalencia negativa entre un excesivo uso del teléfono móvil y los resultados académicos. Para su verificación, elaboramos un índice de procrastinación (IP), normalizado posteriormente (IPN)  para que tomara valores iguales o mayores que cero, calculado a partir del cuestionario utilizado como uno de los instrumentos de investigación. Partiendo de las 897 respuestas recabadas, enviadas desde 21 países, se ha procedido a su clasificación en seis bloques diferenciados, con el fin de facilitar su análisis. Por otra parte, para comprobar la correlación estadística existente entre las variables estudiadas, se ha diseñado otro cuestionario dirigido a alumnos del IES Los Albares, Cieza, de entre 3º de la ESO y 2º de Bachillerato que se ha cruzado con los datos de uso de sus teléfonos durante 352 semanas para 52 participantes. Tras el procesamiento y posterior análisis de la información obtenida, se ha comprobado que una puntuación elevada en cuanto a IPN complementada con un uso excesivo del teléfono móvil, (“tecno-procrastinación”) no implica una disminución en el rendimiento académico. Por tanto, los resultados contradicen la hipótesis formulada.

Effective time management is an essential aspect of academic results. The use of the mobile phone and its influence on the proper management of the student's time forms the core of this work. The starting hypothesis presupposes a negative equivalence between excessive use of the mobile phone and academic results. For its verification, we elaborated a procrastination index (PI), later normalized (NPI) to take values ​​equal to or greater than zero, calculated from the questionnaire used as one of the research instruments. Based on the 897 responses collected, sent from 21 countries, they have been classified into six distinct blocks in order to facilitate their analysis. On the other hand, to verify the statistical correlation between the variables studied, another questionnaire has been designed for students of the IES Los Albares, Cieza, between the 3rd year of secondary school and the 2nd year of high school, which has been crossed with the usage data of their phones during 352 weeks for 52 participants. After processing and subsequent analysis of the information obtained, it has been found that a high NPI score complemented by excessive use of the mobile phone (“techno-procrastination”) does not imply a decrease in academic performance. Therefore, the results contradict the hypothesis formulated.
Machine Learning para la mejora de la experiencia con MOOC: el caso de la Universitat Politècnica de València
Authors: Martinez Navarro Jorge Angel , Despujol Zabala Ignacio
Published: June 2021

El trabajo que se presenta tiene como objetivo el diseño de una propuesta de mecanismos automatizados fundamentados en machine learning para la mejora de la experiencia de los participantes en los cursos MOOC de la Universitat Politécnica de Valencia y la reducción de las tasas de abandono. Siguiendo una estrategia de investigación basada en el diseño IBD, en la que se ha priorizado siempre las decisiones pedagógicas por encima de las propias analíticas de datos, se han realizado tres iteraciones con distintos patrones metodológicos (revisión sistemática de literatura, machine learning basado en los datos de 260 cursos y más de 700.000 estudiantes, y creación de mecanismos automatizados) que siempre finalizan con la presentación de resultados y la realimentación por parte del equipo de la universidad. Las principales conclusiones de este trabajo indican que, de los veinticinco indicadores pedagógicos de abandono referidos por las revisiones bibliográficas en la iteración 1, solo se validan diez de ellos con los cursos de la UPV (no se tienen datos automáticos ni automatizables de los otros), y de esos finalmente solo seis de ellos son posibles predictores del abandono del alumnado, con los datos utilizados. Se proponen finalmente un conjunto de mecanismos automatizados que se aplicarán en la plataforma EdX de la universidad, para la mejora de la experiencia de los usuarios y la reducción de la tasa de abandonos en los cursos.

The aim of this paper is to design a proposal for automated mechanisms based on machine learning to improve the experience of participants in MOOC courses at the Universitat Politécnica de Valencia and reduce dropout rates. Following a desing based research DBR design, in which pedagogical decisions have always been prioritised over data analytics, three iterations have been carried out with different methodological patterns (systematic literature review, machine learning based on data from 260 courses and 700.000 students, and creation of automated mechanisms) that always end with the presentation of results and feedback from the university team. The main conclusions of this work indicate that, of the twenty-five pedagogical dropout indicators referred to by the literature reviews in iteration 1, only ten of them are validated with UPV courses (no automated or automatable data are available for the others), and of those finally only six of them are possible predictors of student dropout, with the data used. Finally, a set of automated mechanisms are proposed to be applied in the university's EdX platform to improve the user experience and reduce the dropout rate in the courses.
La Competencia Digital Docente, una revisión sistemática de los modelos más utilizados
Authors: Jiménez Hernández David , Muñoz Sánchez Práxedes , Sánchez Giménez Fulgencio S.
Published: June 2021

Partiendo del interés social y educativo actual, este artículo pretende conocer el estado de la cuestión en el campo de la Competencia Digital Docente (CDD), con la finalidad de saber cómo se encuentra el trabajo de estas destrezas tanto en el ámbito teórico como empírico. Para ello se han recopilado diferentes modelos que destacan por su uso como guías de formación para facilitar su desarrollo. Este estudio ha tenido en cuenta diferentes países e instituciones, así como sus características, finalidades y dimensiones. Además en todas se remarcan investigaciones que los modelos emplean para favorecer la adquisición de estas competencias, así como su análisis en controversias y perspectivas de la comunidad educativa y la praxis en las políticas educativas. A lo largo de todos estos modelos de CDD, se ha podido comprobar la gran carga de responsabilidad tanto a nivel institucional como del profesorado en la adquisición de competencias digitales, para poder responder a las demandas sociales y educativas planteadas en todos los niveles de formación.

Due to the current interest in the Teacher Digital Competence (TDC), both from the social and education fields, this article shows its state-of-art, in order to find out how the work on these skills is going both theoretically and empirically. Thus, we compile different models that stand out as training guides that facilitate TDC's development. We analyze different countries and institutions for this study, as well as their characteristics and purposes. For each model, we highlight research results that the models are based on to facilitate gaining TDC skills. We analyze how the educational community evaluates them and their results after their implementation in educational policy. We reveal that each TDC model implies a great burden of responsibility for institutions and educators. In order to be able to respond to the social and educational requirements raised at all levels of training, all models strongly rely on the educational community to gain digital competence.
Reescrituras interseccionales del cuerpo no normativo: el caso de Special
Authors: Martínez Pleguezuelos Antonio Jesús
Published: June 2021

En esta investigación entenderemos los medios de comunicación audiovisuales como una vía de gran alcance, capaces de llegar a casi cualquier rincón del planeta en cuestión de segundos. Gracias a esta ubicuidad, el poder social y cultural con el que cuentan es incontestable, y pueden contribuir en gran medida a desarrollar, difundir y fijar narrativas identitarias con facilidad. La traducción actúa en estos casos multiplicando el efecto expansivo de su eficacia al llevar tales discursos a otras sociedades en otros idiomas. Nos interesará profundizar en cómo se presentan las identidades interseccionales en los medios, sobre todo aquellas atravesadas por diferentes ejes de poder, que limitan su visibilidad y marginan a los sujetos. Adoptaremos una metodología interseccional a partir de conceptos del ámbito de los estudios culturales y, sobre esta estructura teórico-metodológica, abordaremos la intersección entre sexualidad y diversidad funcional en la serie Special de Netflix. Se tendrá en cuenta si las reescrituras al español en el doblaje y subtitulado se han basado en representaciones simplistas de la identidad, anquilosadas en estereotipos caducos, o si, por el contrario, se han empleado estrategias discursivas multifocales capaces de reflejar la complejidad de dichas identidades.
On the institutional obstacles to bringing judges, arbitrators, and the state to civil liability
Authors: Chibinov Dmitrii Vladislavovich
Published: June 2021

The subject of this article is the analysis of the approach of Russian legislator, which links the civil liability of a judge, arbitrator or the state (in accordance with Paragraph 2 of the Article 1070 of the Civil Code of the Russian Federation) with the criminal liability of a judge or arbitrator. The author also considers the following questions: the violation of victim’s right due to the actions of a judge or arbitrator; what would happen if a civil claim of compensation for damages is filed against a judge, arbitrator or the state prior to receiving a court verdict; what are the legal consequences of filing such “preliminary claim”; how to calculate the time allowed for filing a claim of compensation for damages caused to victims. The main conclusion of consists in the observation that the model selected by the legislator implies the creation of an institutional obstacle to compensation for losses caused in dispute settlement: the need for preliminary imposition of liability on a judge or. In this regard, the verdict of the court should not be considered as exclusive evidence of such an element of the tort as "guilt". The victim would not be able file claims for damages against a judge, arbitrator, or the state prior to receiving the correspondent court verdict, and the submitted claim should not be accepted for trial. Thus, the time allowed for filing a claim of compensation for damages starts from the moment of receiving a court verdict, which has entered into force against a judge or arbitrator.
HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness
Authors: Ho Jessica SY , Di Tullio Federico , Schwarz Megan , Low Diana , Incarnato Danny , Gay Florence , Tabaglio Tommaso , Zhang JingXian , Wollmann Heike , Chen Leilei , An Omer , Chan Tim Hon Man , Hall Hickman Alexander , Zheng Simin , Roudko Vladimir , Chen Sujun , Karz Alcida , Ahmed Musaddeque , He Housheng Hansen , Greenbaum Benjamin D , Oliviero Salvatore , Serresi Michela , Gargiulo Gaetano , Mann Karen M , Hernando Eva , Mulholland David , Marazzi Ivan , Wee Dave Keng Boon , Guccione Ernesto
Published: June 2021

High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens identified heterogeneous nuclear ribonucleoprotein M (HNRNPM) as a regulator of PCa cell growth. RNA- and eCLIP-sequencing identified HNRNPM binding to transcripts of key homeostatic genes. HNRNPM binding to its targets prevents aberrant exon inclusion and backsplicing events. In both linear and circular mis-spliced transcripts, HNRNPM preferentially binds to GU-rich elements in long flanking proximal introns. Mimicry of HNRNPM-dependent linear-splicing events using splice-switching-antisense-oligonucleotides was sufficient to inhibit PCa cell growth. This suggests that PCa dependence on HNRNPM is likely a result of mis-splicing of key homeostatic coding and non-coding genes. Our results have further been confirmed in other solid tumors. Taken together, our data reveal a role for HNRNPM in supporting cancer cell fitness. Inhibition of HNRNPM activity is therefore a potential therapeutic strategy in suppressing growth of PCa and other solid tumors.
Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
Authors: Alghoul Fatima , Laure Schaeffer , Eriani Gilbert , Martin Franck
Published: June 2021

During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5’UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation. The second regulon is a translation inhibitory element or TIE, which ensures concomitant cap-dependent translation inhibition. In this study, we deciphered the molecular mechanisms of mouse Hoxa3 and Hoxa11 TIEs. Both TIEs possess an upstream open reading frame (uORF) that is critical to inhibit cap-dependent translation. However, the molecular mechanisms used are different. In Hoxa3 TIE, we identify an uORF which inhibits cap-dependent translation and we show the requirement of the non-canonical initiation factor eIF2D for this process. The mode of action of Hoxa11 TIE is different, it also contains an uORF but it is a minimal uORF formed by an uAUG followed immediately by a stop codon, namely a ‘start-stop’. The ‘start-stop’ sequence is species-specific and in mice, is located upstream of a highly stable stem loop structure which stalls the 80S ribosome and thereby inhibits cap-dependent translation of Hoxa11 main ORF.
Cartas de México al Mundo
Authors: Vilchis Angélica Radahi , Nechar Marcelino Castillo , Jimenez Graciela Cruz , Los Monteros Gerardo Novo Espinosa de
Published: June 2021

El manejo institucional de la promoción de los destinos turísticos se ha visto favorecido con el uso del video en internet como medio efectivo para llegar al usuario y desplegar valores solidarios hacia los lugares que visita. Ante el escaso análisis de las estrategias de promoción turística oficial de México, bajo esos valores, este artí-culo tiene como objetivo realizar un análisis crítico de contenido en la estrategia promocional de la Secretaría de Turismo, denominada Cartas de México al Mundo operacionalizado con el software Atlas.ti. Para ese análisis crítico, el diseño teórico-metodológico reúne reflexiones en torno al papel de las industrias culturales y los medios de comunicación masivos, el análisis de contenido de mensajes en medios audiovisuales, hasta la resignificación de los códigos y categorías susceptibles del análisis en cuestión, para evidenciar el sentido que adquiere del contenido promoci-onal turístico on line en la estrategia turística de México. El principal hallazgo mues-tra la reproducción de un modelo convencional, más allá de la pretensión asumida de hacer del turismo una herramienta de cohesión social.