bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptome Analysis of Intestinal Dysfunction in Newborn Piglets with Intrauterine Growth Restriction and Improve their Performance by Dimethylglycine Sodium Salt Supplementation after Weaning
Authors: Bai Kaiwen , Jiang Luyi , Li Qiming , Zhang Jingfei , Zhang Lili , Wang Tian
Published: April 2021

Background

Few studies are available on the mechanism of intestinal dysfunction in newborn piglets with intrauterine growth restriction (IUGR). This work aimed to study the mechanism of jejunum dysfunction in IUGR newborn piglets through RNA-seq and improve their performance by dimethylglycine sodium salt (DMG-Na) supplementation after weaning.
Methods

In total, 13 normal birth weight (NBW) newborn piglets and 23 IUGR newborn piglets were obtained. Among them, 3 NBW and 3 IUGR newborn piglets were selected and stunned by electric shock after birth without suckling and collected the jejunum samples for RNA-sEq. After weaning at 21 days, they were randomly assigned to 3 groups (n = 10): NBW weaned piglets fed with common basal diets (N); IUGR weaned piglets fed with common basal diets (I); IUGR weaned piglets fed with common basal diets plus 0.1% DMG-Na (ID). All piglets are slaughtered at 49 days of age to collect serum and jejunum samples.
Results

The hub genes, including ATP8, C11orf86, CDKN1C, DDX58. HPX, INHBB, LECT2, ND1, NFIX, PRDM5, PSD3, SCD, and ZNF770, were found from the data analyzed by RNA-seq and WGCNA. Interestingly, we found ATP8 was the most significantly changed gene, which was crucial in maintaining mitochondrial function. After weaning, the growth performance of ID group was improved (P < 0.05) compared to that in I group. Jejunum histological morphology and its sub-organelle ultrastructure, serum immunoglobulin, jejunum sIgA level, and jejunum digestive enzyme activity were improved (P < 0.05) in ID group compared to those in I group. The redox status of serum, jejunum and its mitochondrial, as well as jejunum redox status-related and mitochondrial function-related gene expression level and protein content were improved (P < 0.05) in ID group in comparison to those in I group.
Conclusion

The activity of the SIRT1/PGC1α pathway was inhibited in the IUGR weaned piglets, which in turn leads to damage to their redox status and jejunum structure and function, and finally lowers their performance. The IUGR weaned piglets activate the SIRT1/PGC1α pathway by taking in the antioxidant substance like DMG-Na, thereby improving their unfavorable body state.
Prognostic Factors in Non-Occlusive Mesenteric Ischemia: A Pragmatic Pre-Operative Score for the Prediction of 28-day Mortality
Authors: CALAME PAUL , Winiszewski Hadrien , Doussot Alexandre , Lakkis Zaher , Verdot Pierre , Pili-Floury Sebastien , Heyd Bruno , Piton Gael , Delabrousse Eric
Published: April 2021

Background
The prognosis of critical ill patients with non-occlusive mesenteric ischemia (NOMI) is poor and not fully understood. Preoperative prognostic factors are needed. The aim of this study was to determine preoperative factors associated with 28-day mortality in a cohort of ICU patients requiring laparotomy for NOMI. The secondary objective was to determine general prognostic factors associated with NOMI.
Methods
This retrospective observational study was performed in a University Hospital among critically ill patients 18 years old or older who underwent a laparotomy for NOMI from January 1, 2009 to December 31, 2019, and who had an available contrast enhanced CT with at least one portal venous phase. Variables were collected at the time of the CT. All variables associated with 28-day mortality were entered into a multivariate cox regression model and were used to compute a NOMI mortality score.
Results
During the study period, 154 patients underwent laparotomy for NOMI after having benefited from an abdominal enhanced CT. The 28-day mortality rate was 56%. Variable at the time of ICU admission and at the time of the CT were collected. Surgical and histopathologic findings were recorded. Multivariable analyses on 28-day mortality including variables at the time of the CT identified three independent variables (i.e. lactates > 7mmol/l, prothrombin rate < 60% and kidney infarction), included in a simple mortality score. For each variable associated with 28 days mortality, 1 point was attributed. Among the study population, the probability of 28-day mortality was 26% (11/42), 54% (26/48), 77% (23/30) and 100% (21/21) for a survival score of 0, 1, 2 and 3, respectively. A second explorative multivariate cox regression model including the variables at the time of ICU admission showed that jejunal transmural necrosis was the only operative finding associated with death (HR = 2.26 CI95%[1.14–4.71]).
Conclusion
We identified three preoperative factors independently associated with short-
Synthetic MRI for Evaluation of Brain Gliomas Grade and Tumor Proliferative Activity：A Retrospective Study
Authors: Xie Jiapei , Zhang Weidong , Xiao Liang
Published: April 2021

PURPOSE

The evaluation of gliomas grade and proliferation contribute to improve prognosis. We explored the clinical value of synthetic MRI in evaluating quantitatively gliomas grade and predicting tumor proliferative activity.
METHODS

Forty-six patients with histopathologically proven gliomas were included in this study and underwent MAGnetic resonance Image Compilation within 1 week before surgery. T1 values pre- and post-contrast agent (T1-pre, T1-Gd) and T2 values pre-contrast agent (T2-pre) were measured in tumor solid parts and normal white matter of contralateral mirror. T1 and T2 values were compared with gliomas grade and expression of proliferation marker Ki-67. Receiver operating characteristic analysis was performed to assess the diagnostic performance of each metric.
RESULTS

The values of T1-pre, ΔT1[(T1-pre) – (T1-Gd)] and Ki-67 labeling index (Ki-67 LI) were significantly higher in the group of high-grade gliomas ( HGGs, n = 26) compared with the group of low-grade gliomas ( LGGs, n = 20), whereas T1-Gd and the ratio of T1-Gd (rT1-Gd, tumor-to-normal ratio) values were significantly lower in the group of HGGs compared with the group of LGGs. Receiver operating characteristic analysis curves showed that ΔT1 values had the highest diagnostic value (sensitivity: 96.20%, specificity: 60.00%) for gliomas grade, and the optical cut-off value was 277.88ms. T1-pre (rs=0.47, P = 0.001) and ΔT1 (rs=0.56, P༜0.001) values were positively correlated with Ki-67 LI. T1-Gd (rs=-0.42, P = 0.004) and rT1-Gd (rs=-0.40, P = 0.007) values were negatively correlated with Ki-67 LI.
CONCLUSIONS

Synthetic MRI is helpful to distinguish HGGs from LGGs and predict the tumor proliferative activity.
First-Line Chemotherapy Response Is a Predictive Factor for Immune Checkpoint Inhibitors Treatment in Advanced Urothelial Carcinoma, a Real World Retrospective Study
Authors: Li Jian-Ri , Wang Shian-Shiang , Lu Kevin , Chen Chuan-Shu , Cheng Chen-Li , Chen Cheng-Che , Hung Sheng-Chun , Lin Chia-Yen , Chiu Kun-Yuan , Hsu Chiann Yi , Yang Cheng-Kuang
Published: April 2021

Background: Immune checkpoint inhibitors (ICIs) have become important tools for the treatment of advanced urothelial carcinoma (aUC). However, the clinical strategy using ICIs and chemotherapy is still controversy. The aim of this study was to evaluate the association of clinical parameters in aUC patients with ICIs treatment.Methods: We retrospectively analyzed aUC patients who received atezolizumab and pembrolizumab between January 2015 and October 2020. The associations between baseline demographics and clinical outcomes were evaluated.Results: Of the 74 included patients, the median age was 67 years. Among them, 53 patients received atezolizumab and the other 21 received pembrolizumab. There were 50 patients receiving first line ICIs therapy and the other 24 received second line monotherapy. Fifty-two (83.87%, 52/62) received cisplatin among all chemotherapy patients. The median progression free survival was 10.94 months and the overall survival was 28.44 months. Poor chemotherapy response or no chemotherapy, liver metastases, Eastern Cooperative Oncology Group (ECOG) status and higher neutrophil/lymphocyte ratio (NLR) were associated with higher risk of diseases progression (HR=5.70, 95% CI 2.04-15.90, p=0.001, HR=6.08, 95% CI 1.79-20.57, p=0.004; HR=5.40, 95% CI 1.76-16.57, p=0.003; HR=6.08, 95% CI 2.56-14.44, p<0.001 and HR= 1.02, 95% CI 1.01-1.03, P=0.002 respectively). Liver metastases and WBC before ICI were associated with increased death risk (HR=11.95, 95%CI 3.22-44.34, p<0.001; HR=1.0001, 95% CI 1.00001-1.00002, p=0.036 respectively) while ICI response was associated with decreased death (HR=0.22, 95%CI 0.08-0.62, p=0.004). Chemotherapy responders were associated with better ICI treatment response (OR=6.52, 95%CI 1.45-29.24, p=0.014) while lymph node metastases and poor ECOG was associated with poor ICI response (OR=0.31, 95%CI 0.10-0.94, p=0.038; OR=0.32, 95%CI 0.11-0.95, p=0.040).Conclusions: Our data showed predictive role of first-line chemotherapy response to ICIs treatment efficacy in aUC patients as well as other prognostic factors, such as ECOG status, serum white blood cell count or NLR and liver metastases.
Biochemical characterisation of potentially contagious haemic neoplasia occurring in the Baltic clam Limecola balthica
Authors: Anna Hallmann , Alicja Michnowska , Agnieszka Chomiczewska , Marcin Lipiński , Katarzyna Smolarz
Published: April 2021

Occurring in marine invertebrates haemic (leukemia-like) neoplasia, a disease of potentially infectious nature, arises from genome instabilities leading to multilevel malfunctions and unregulated cell division of presumably haemocyte precursors. As its biochemical characterisation remains unknown, we here present results describing selected physiological and biochemical aspects of the disease measured in neoplastic and healthy clams Limecola balthica. Activities of adenosine deaminase (ADA), alkaline phosphatase (ALP) and FAA levels were measured in haemolymph but no differences in ADA and ALP activities between healthy and neoplastic clams were found. In both clam groups nine FAAs were detected with Asp, Glu, Pro, Ser constituting over 90% of total FAA content. Significantly higher Gln level was detected in leukemic-like clams suggesting an essential role of this FAA in cancer energy production. In neoplastic cells, an impairment of mitochondrial metabolism was observed as a decrease in mitochondrial oxygen consumption and lower cytochrome c oxidase activity. Neoplastic clams were also characterised by significantly higher concentration of ROS, but no elevated response of the oxidative stress markers were found suggesting an efficient antioxidant response. Finally, we, for the first time, report high levels of corticosterone and lower amounts of dehydrocorticosterone, cortisol and cortisone in healthy clams with elevated cortisol level found in neoplastic individuals.
Assessment of diabetes self-management among diabetic patients attending Jeddah Care Center for Diabetes, Saudi Arabia.
Authors: Alqahtani Reem , Alzahrani Sami , Alhemedi Moneerah , Hawsa Asya , Idris Sarah , Alotaibi Shomokh
Published: April 2021

Objectives:To assess the levels and the associated demographic factors with diabetic self- management (DSM) among diabetic patients in Saudi Arabia. The impact of implementing DSM practices on glycemic control was additionally investigated.Results:The responses of 349 patients were analyzed (51.0% males and 37.2% obese). The median (IQR) raw DSMS score was 187 (165-205). Higher DSMS scores were reported for young adults (aged 20-29 years), insulin users, employed patients, as well as those with normal body mass index values and normal HbA1c results compared to their counterparts. Low HbA1c values were linearly associated with high scores of the healthy eating (β = -0.014, p=0.018) and physical activity subscales (β = 90-0.009, p=0.042).Keywords : Self-management; diabetes; glycemic control; Saudi Arabia.
The nature of the relationship between the money supply and inflation in the Jordanian economy (1980–2019)
Authors: Batarseh Atif
Published: April 2021

This study aims to investigate the relationship between the money supply (M1) and inflation in the Jordanian economy during the period of 1980–2019.To achieve the goal of the study, the methodology of econometric analysis of time series was used through the following tests: Augmented Dickey-Fuller (ADF) test – to test the stability of the study variables, Johansen’s Cointegration Approach – to determine the long-term equilibrium relationship between the study variables, and the Granger Causality Test – to determine the direction of the causal relationship if it exists in the short term.The study results demonstrate that inflation has stabilized at the level, while the money supply M1 was unstable at the level and stabilized after taking the first difference. The Cointegration test results indicated that there was no causal link between the money supply M1 and inflation in the long term. Finally, the results of Granger Causality presented a unidirectional causality running from the money supply M1 to inflation in the short term, meaning that money supply causes inflation, not vice versa; this means that the money supply M1 can explain the changes that occur in the consumer price index (CPI) in the Jordanian economy.The study recommends that the monetary authority in Jordan should have greater control over the money supply due to its impact on the stability of the general level of prices, in order to avoid a repeat of the 1989 crisis represented by the sharp decline of the dinar exchange rate against other currencies and an increase in inflation that year to 25.6%.
KEEPING HARMONY OF INDONESIAN-JAPANESE INTERCULTURAL MARRIAGE INTERACTIONS
Authors: Yunus Ulani , Luke Joice Yulinda , Wahyuningtyas Bhernadetta Pravita , Mahestu Gayes , Ayu Yuni
Published: April 2021

The purpose of this study is to explain how intercultural families interact in maintaining harmony within the family, especially the interaction between Indonesian Moms and Japanese Fathers. The method used in this study is qualitative with primary sources through in-depth interviews.Data analysis is done by reducing the data that has been obtained from the interviews, compared with the concept of intercultural communication and acculturation. The data is validated with secondary data that is the result of previous research. The results obtained show that the couple of Indonesian wives and Japanese husbands keep each other harmony interaction by choosing the appropriate language situation required. They use everyday language are: English, Japanese and Indonesian. The dominant language is the language in where they live. This result shows that they are showing respect for each other. The use of the chosen language as an effort to adapt to the culture in where they live includes also invited their children to always appreciate the cultureof their fathers and mothers equally in influence. So the three behavioral barriers do not occur as a priori, prejudice and authority that one against the other. There is a trust between them. Acculturation in this family is seen as a cultural enrichment,cultural differences do not create barriers to family interaction and with the environment. Father and Mother bequeathed culture to their children in a balanced and without dominance, there is balance in power.
Intermittent water supply systems and their resilience to COVID-19: IWA IWS SG survey
Authors: Farmani R. , Dalton Joe , Charalambous Bambos , Lawson Elizabeth , Bunney Sarah , Cotterill Sarah
Published: April 2021

There is limited information about the current state of intermittent water supply (IWS) systems at the global level. A survey was carried out by the Intermittent Water Supply Specialist Group of the International Water Association (IWA IWS SG) to better understand the current state of these systems and challenges that water companies may have faced under COVID-19 pandemic and to capture successful management strategies applied by water utilities. The survey consisted of three parts: (1) general information about IWS systems, (2) current state of IWS and (3) resilience of IWS under COVID-19 conditions, as well as some questions about potential interventions in order to improve system performance in general and under future uncertain conditions. The survey responses were evaluated based on the Safe & SuRe resilience framework, assessing measures of mitigation, adaptation, coping and learning, and exploring organisational and operational responses of IWS utilities. Infrastructure capacity and water resources availability were identified as the main causes of intermittency in most water distribution systems, while intermittent electricity was considered as the main external cause. Participants indicated that some risk assessment process was in place; however, COVID-19 has surpassed any provisions made to address the risks. Lessons learnt highlighted the importance of financial resources, e-infrastructure for efficient system operation and communication with consumers, and the critical role of international knowledge transfer and the sharing of best practice guidelines for improving resilience and transitioning towards continuous water supply.
Oil palm empty fruit bunch valorization for activated and non-activated carbon nanoparticles and its heavy-metal-removal efficiency
Authors: Zubaidah Salma , Putri Hartoyo Adisti Permatasari , Sihombing Januard Kristian , Herliyana Elis Nina , Darmawan Saptadi , Sari Nela Rahmati , Prabowo Muhammad Naufal Ibrahim , Hermawan Imam , Maulida Isna , Solikhin Achmad
Published: April 2021

In this study, we examined activated and non-activated carbon nanoparticles (CNPs) derived from oil palm empty fruit bunch (OPEFB) fibers for their nanomaterial characteristics and their potential effectiveness in heavy metal removal. To investigate these properties, transmission electron microscopy, scanning electron microscopy (SEM), EDX, Fourier transform infrared spectroscopy, particle size analysis, X-ray diffraction, and atomic absorption spectrophotometry were employed. This study shows that both the activated and the non-activated CNPs were in the form of well-dispersed and aggregated particles. As analyzed using SEM, the external surfaces of the non-activated CNPs were determined to be irregular, while those of the activated CNPs had a more circular shape without aggregation. Carbon was the most dominant element observed in these CNPs, and the occurrence of its activation process altered the chemical functional groups of the non-activated CNPs by shifting their wavenumbers and intensities. Additionally, the activation process increased the crystallinity domain in the activated CNPs. OPEFB fibers could be valorized to obtain both activated and non-activated CNPs that had the potential efficiency to remove heavy metals, including copper (Cu), lead (Pb), iron (Fe), and zinc (Zn) at certain times. Based on the analysis of the Langmuir and Freundlich models, the activated and non-activated CNPs were found to have shown favorable adsorption to Cu, Pb, and Fe, with a percentage of heavy metal removal of over 84%. The adsorption of heavy metals was carried out via a chemical process.
Acessibilidade, Amorosidade e Assistencialidade
Authors: Bernardino Sirino Marcio
Published: April 2021

Este presente artigo nasce das reflexões sobre a importância de se organizar as práticas (socio)educativas desenvolvidas em ambientes escolares e não escolares. Para esta finalidade, traz uma discussão sobre três pilares que devem sustentar estas práticas, a saber: acessibilidade, amorosidade e assistencialidade. Por meio de uma investigação bibliográfica, o texto discute concepção de educação, espaços formativos, as demandas que emergem dos diferentes sujeitos, a busca por uma formação humana mais completa e a construção de uma ponte entre a educação e o social a partir do campo do saber da Pedagogia Social.
A humanidade às avessas em “A terra dos meninos pelados” de Graciliano Ramos
Authors: Souza da Rocha Maria , Cabral Magalhães Suiane
Published: April 2021

Este artigo tem como objetivo analisar a obra do autor Gracilinao Ramos, A terra dos meninos pelados, evidenciando atrajetória de Raimundo, menino sonhador, protagonista do conto, que enfrenta discriminação e cria um mundo fantástico, terra de Tatipirun, como forma de reconstrução daa realidade. As principais discussões do texto propõem reflexões sobre as obras de Edgar Morin(2003) e Mikhail Bakhtin(1929), evidenciando os desafios de se construir uma sociedade plural e um conhecimento ecológico, as complexidades de uma modernidade líquida que agrega uma multiplicidade de valores, mas que tende ao enfraquecimento das relações sociais, influenciando todas as áreas do saber. A metogologia do trabalho é qualitativa e utiliza a pesquisa bobliográfica.
‘'Tornando Real o Alto Potencial Humano’’
Authors: Deluque Júnior Romano , Marton Cesar , Almada Matheus
Published: April 2021

O presente estudo possui por objetivo expor e debater alguns dos corolários que servem de base para a Psicologia Positiva. Embora contenha em si mesma, componentes epistemológicos atravessados, concebe-se aqui, Arthur Seligman e Mihalyi Csikszentmihalyi como os seus fundadores e principais expoentes, tendo apresentado as primeiras diretrizes sobre a abordagem na obra “Positive Psychology: an introduction”. Para cumprir esse objetivo elaborou-se um ensaio de discussão teórica. Os temas aqui enfocados, que remetem às raízes da Psicologia Positiva são: o bem estar subjetivo; o ser humano pela perspectiva bio-cultural; o otimismo; e a felicidade.
Contribuições dos contos de fadas para o desenvolvimento Psicossocial infantil
Authors: Porto de Figueiredo Raisa , Barbosa da Silva Roberta
Published: April 2021

Presentes na infância, os contos de fadas abordam experiências cotidianas, permitindo que as crianças se identifiquem com as dificuldades ou alegrias de seus personagens, desempenhando um papel fundamental no seu desenvolvimento. Nessa perspectiva, este artigo objetivou abordar sobre a importância dos contos de fadas no desenvolvimento psicossocial infantil. Para tal, realizou-se uma revisão da literatura quanto a história e estrutura dos contos de fadas, o desenvolvimento psicossocial infantil e as contribuições dos contos de fadas nesse aspecto. Por fim, notou-se o aporte dessa literatura no autoconhecimento, personalidade, entendimento das emoções e da sociedade em que está inserido e no reconhecimento dos conflitos e dilemas, contribuindo, assim, para o seu desenvolvimento psicossocial.
A satisfação com a vida dos egressos de cursos técnicos profissionais em relação ao mercado de trabalho: a perspectiva da psicologia positiva.
Authors: Lazaro Rhennan , Maria Melo Gonçalves Sílvia
Published: April 2021

O presente estudo descreve a satisfação com a vida dos egressos dos cursos técnicos integrados, concomitantes e subsequentes, do Instituto Federal Goiano – Campus Avançado Ipameri, no contexto do mercado de trabalho. A compreensão sobre a Qualidade de Vida (QV) envolve domínios que contribuem para o bem-estar das pessoas, como a moradia, os relacionamentos, a saúde, e, nesta abordagem, o trabalho. A discussão sobre QV diz respeito ao posicionamento dos indivíduos diante dos diversos elementos da vida, considerada a partir da percepção de fatores que contribuem com o bem-estar físico, mental e espiritual, pois esses fatores são importantes diante a configuração da vida em sociedade. Participaram desta pesquisa 54 egressos, de ambos os sexos, entre 18 a 50 anos de idade, residentes em Ipameri e cidades circunvizinhas. O instrumento utilizado foi um questionário misto com 04 perguntas orientadas a explorar como o IF Goiano contribuiu para a inserção no mercado de trabalho, o exercício profissional, sua satisfação com o trabalho e para a aplicação de ações empreendedoras. A análise dos dados obtidos com a pesquisa foram categorizadas em frequência simples e percentual, de acordo com a Análise de Conteúdo da Bardin (2011). A pesquisa foi submetida e aprovada pelo Comitê de Ética na Pesquisa com Seres Humanos da UFRRJ. Diante a abordagem da Educação Técnica Profissional no Brasil, do Mercado de Trabalho e da Psicologia Positiva, tem-se em seus resultados a compreensão da importância da educação profissional e, principalmente, do acesso ao ensino público e de qualidade, conforme percebeu-se pelos resultados apresentados.
Depression and anxiety in learning of children and adolescents
Authors: Moreira Mayra Patricia Santana , Espinoza Luis Alberto Vera , Manzaba Freddy Daniel Magallanes , Chávez Ligia Lisseth Resabala
Published: April 2021

The purpose of the research is to analyze the impact that psychological disorders such as depression and anxiety have on the education of children and adolescents. This subject is valued in the educational field where the need arises to know the different causes and consequences of this problem to carry out educational practices according to the needs of the students. Several scientific theories obtained through the documentary bibliographic review are exposed, making comparisons based on opinions from different reliable sources, applying the qualitative approach, allowing relationships between different areas from the macro to what happened at the national level and the local context where the events take place students. The results determined the importance of communication between the family of students with depression and anxiety with the educational community, to jointly plan actions for the benefit of students.
Karakter Pohon Area Sekitar Sumber Mata Air Di Malang Raya, Jawa Timur
Authors: Fathoni Akhmad , Rohman Fatchur , Sulisetijono Sulisetijono
Published: April 2021

Keberadaan vegetasi pohon di suatu wilayah dapat berdampak positif bagi keseimbangan ekosistem di sekitarnya. Manfaat pohon selain bisa mengurangi limpasan dan erosi laju air hujan, akar pohon dapat meningkatkan kualitas kuantitas airtanah melalui kemampuannya mengikat air. Sumber daya air di Indonesia terutama di Malang Raya Jawa Timur begitu melimpah, namun memiliki ancaman kelangkaan air bersih sebagai konsekuensi dari kemajuan dan pertumbuhan jumlah penduduk yang menuntut adanya perubahan fungsi penggunaan lahan. Alih fungsi tata guna lahan dengan membangun pemukiman dan pengembangan pariwisata di sekitar sumber mata air sudah banyak terjadi di Malang Raya, yang tentunya berdampak pada berkurangnya daya serap tanah. Area sekitar mata air merupakan kawasan konservasi yang berfungsi sebagai habitat vegetasi pohon tumbuh. Berdasarkan permasalahan tersebut maka perlu dilakukan pengamatan struktur komposisi pohon yang bertujuan untuk mengetahui karakter pohon area sekitar sumber mata air di Malang Raya Jawa Timur. Metode plot digunakan untuk mengambil data, dengan membagi area menjadi empat stasiun. Setiap stasiun penelitian dibagi menjadi tiga titik plot hingga total 12 plot dalam satu lokasi penelitian. Pengambilan data dilakukan secara jelajah bebas dimulai dari tepi mata air hingga jarak maksimum ±50m mengelilingi titik mata air. Hasil dari penelitian ini adalah struktur vegetasi pohon yang menjadi penciri berdasarkan INP yang bervariasi pada tiap lokasi pengamatan, yakni karakter vegetasi (Myrta-Moraceae) di Petirtaan Yai Beji Sari; (Meliaceae) di Sumber Sira; (Areca-Meliaceae) di Sumber Wendit; (Melia-Poaceae) di Sumber Waras; dan (Araucariaceae) di Sumber Cangar.
Improving Quality of Life with Percutaneous Coronary Intervention in Chronic Coronary Syndrome Patients with SYNTAX Score of More than 22
Authors: Karolina Wella , Saifur Rohman Mohammad , Supriadi Pawik , Sargowo Djanggan , Kimahesa Anggoro Wira , Waranugraha Yoga
Published: April 2021

Background : The benefit of PCI to improve quality of life (QoL) in chronic coronary syndrome (CCS) is still unclear. Objectives : This study aimed to assess the benefit of percutaneous coronary intervention (PCI) in improving QoL among CCS patients receiving OMT. Methods : We conducted a retrospective cohort study. CCS patients who underwent coronary angiography (CAG) and/or PCI were grouped into OMT plus PCI and OMT groups. The SYNTAX score was used to assess the complexity and severity of coronary artery lesions. The outcome measured was QoL assessed using Seattle Angina Questionnaire (SAQ) and rehospitalization. Results: A total of 57 patients in the OMT plus PCI group and 49 patients in the OMT group were included. The percentage of patients with good QoL was higher in the OMT plus PCI group than OMT only group (64.5% vs. 35.5%; p = 0.007). The OMT plus PCI group revealed a better activities of daily living (85.11 ± 12.46 vs. 12.46 ± 21.87; p = 0.014) and angina stability (84.32 ± 23.63 vs. 71.81 ± 27.89; p = 0.014) than OMT group. Among patients with SYNTAX scores of more than 22, achievement of good QoL was greater in the OMT plus PCI group than the OMT group (80.8% vs. 45.5%; p = 0.025). Conclusion: PCI improved the QoL in CCS patients treated with OMT. Second, OMT plus PCI improves physical limitation and angina stability. For patients with a SYNTAX score of more than 22, OMT plus PCI was correlated with good QoL achievement.
Kemitraan dalam Pengembangan Potensi Pariwisata (Studi pada Dinas Kebudayaan dan Pariwisata Kabupaten Tulungagung)
Authors: Nurhalimah Zulfaisya
Published: April 2021

In order to increase local original revenue (PAD), the potential of the tourism sector is the main attraction in the current era, where the development of the tourism sector is something that must be considered in a logical and realistic way. Tourism is a sector that must continue to be developed by both the central government and regional governments. Because, the tourism sector has an important role in terms of development and income to increase PAD (Local Original Revenue). In the process of developing tourism potential, local governments often encounter several obstacles, namely one of them is the budget problem in the development of tourism which is still relatively small in number, while the tourism potential is large.
Kualitas Layanan Administrasi Akademik di Politeknik Negeri Pontianak
Authors: Along Antonius
Published: April 2021

This research was conducted to find out, describe and explain about the quality of academic administrative services in the Pontianak State Polytechnic by using a qualitative research method with a descriptive approach. Data collection techniques, interviews, observation and documentation, interactive data analysis models of Miles, Huberman, & Saldana (2014). The results showed that the quality of academic administration services in Pontianak State Polytechnic has not been going well, improvements need to be made by academic staff in terms of service quality. a) Improving academic service infrastructure; b) Leaders of the Pontianak State Polytechnic should provide training/ workshops on services prime; c) Control employee performance through measuring student satisfaction index activities; and d) Able to be consistent in providing services in accordance with academic service hours so that the services provided can run well.
Implementasi Undang-Undang Nomor 8 Tahun 2015 tentang Pemilihan Gubernur, Bupati dan Walikota pada Pilkada Serentak Tahun 2015 (Studi Kasus pada Pelaksanaan Pilkada di Kabupaten Malang, Provinsi Jawa Timur Tahun 2015)
Authors: Nurakhmadi Dito Arief
Published: April 2021

With the presence of Law No. 8 of 2015 concerning Amendments to Law No. 1 of 2015 concerning Stipulation of Government Regulation in Lieu of Law No. 1 of 2014 concerning Regional Head Elections, there are a number of changes to the rules related to the mechanism for the implementation of Regional Head Elections directly and simultaneously. This study aims to describe the implementation of Law No. 8 of 2015 concerning the Election of Governors/ Regents/ Mayors in Organizing Pilkada in Malang Regency 2015. The research method used is descriptive qualitative method. The findings suggesst the product evaluation in the case of the evaluation of the Malang District Election policy in 2015 is the final result of the policy evaluation which can be used as an improvement in the new Election Law, both legally and in its implementation. UU no. 8 of 2015 concerning the Election of Governors, Regents and Mayors in the Simultaneous Local Election in 2015 has many shortcomings that can be said to be bad policy, and has several shortcomings in terms of implementation.
Pengaruh Kualitas Informasi Akuntansi dan Kapasitas Manajer terhadap Kualitas Keputusan dalam Hubungannya dengan Kinerja Keuangan (Studi pada Badan Layanan Umum Universitas Brawijaya)
Authors: Hadiyana Amalia , Hakim Abdul , Suryadi Suryadi
Published: April 2021

This research is a descriptive-verificative study, which aims to identify the relationship between management accounting information quality and manager's capacity to decisions quality related to financial performance, studies at the Public Service Board of Brawijaya University. The research was conducted through questionnaire data collection from 63 respondents consisting of leaders in faculties and postgraduate programs, and financial ratios to measure the financial performanceof year 2018. The method of data analysis used was Partial Least Square (PLS). The results of this study indicate that: (a) management accounting information quality has a significant effect on decisions quality; (b) manager capacity has a significant effect on decisions quality; (c) directly, management accounting information quality has no significant effect on financial performance; (d) directly, managers capacity has no significant effect on financial performance; and (e) decisions quality has a significant effect on financial performance.
POPULATION CONTROL POLICIES IN THE SPECIAL REGION OF YOGYAKARTA AFTER TOTAL FERTILITY RATE INCREASED BASED ON IDHS 2017
Authors: Alfana Muhammad Arif Fahrudin , Pitoyo Agus Joko , Laudiansyah Rizky , Sugiharti Sri
Published: April 2021

This study has two main objectives. The first is to explain the achievement of the value of Total Fertility Rate (TFR) in the Special Region of Yogyakarta (DIY). The second is to explain the population control policy after the increase in TFR in DIY results of the 2017 IDHS. The population control policy taken by the DIY government comes from the Grand Design of Population Development document published by the People's Welfare Bureau. The method used in this study is library research. The analyst uses qualitative descriptive. The results showed that according to IDHS data, there had been fluctuations in the value of TFR during 1991-2017. In the last ten years, the pattern of TFR values in DIY has tended to increase. Population control is necessary to prevent this tendency. The policies taken by the government in the future in terms of population control in DIY include suppressing population growth rates, maturing marital age, controlling the value of TFR, and increasing the prevalence of contraception. The DIY government will implement at least this policy until 2035.
APPLICATION OF E-GOVERMENT SYSTEM AS AN EFFORT TO CREATE A CONDUCIVE INVESTMENT CLIMATE IN BANYUWANGI REGENCY
Authors: Maulana Arief , Aryaputri Hafiza , Rosyari Fandi Rizki
Published: April 2021

One of the efforts made by the government to increase development is by developing the field of investment, because economically investment is the first step in production activities. In this regard, to create a realization of sustainable investment, a conducive investment climate is needed. A conducive investment climate in the economy is a hope for the community, investors, business people and the government. This study aims to analyze and explain the strategies of the Banyuwangi Regency Government as an effort to create a Conducive Investment Climate that is useful for regional development. This research was conducted using qualitative methods with a case study approach. Data collection techniques that will be used in this study include interviews, focus group discussions, documentation and literature studies. The results showed that BanyuwangiRegency implemented regulations on investment by implementing several e-Government applications that had the function of transparency, accountability, and facilitating public services related to investment. E-government leads to good governance because government services are more transparent, effective and efficient so as to form public trust which has an impact on increasing investment interest by investors. The increase in investment was also caused by policies or regulations that favored the creation of a conducive investment climate.
The Digital Engagement of Older People: Systematic Scoping Review Protocol
Authors: Kebede Abraham Sahilemichael , Ozolins Lise-Lotte , Holst Hanna , Galvin Kathleen
Published: April 2021

Background

There is an ongoing negative narrative about aging that portrays older people as a socioeconomic burden on society. However, increased longevity and good health will allow older adults to contribute meaningfully to society and maximize their well-being. As such, a paradigm shift toward healthy and successful aging can be potentially facilitated by the growing digital technology use for mainstream (day-to-day activities) and assisted living (health and social care). Despite the rising digital engagement trend, digital inequality between the age groups persists.

Objective

The aims of this scoping review are to identify the extent and breadth of existing literature of older people’s perspectives on digital engagement and summarize the barriers and facilitators for technological nonuse, initial adoption, and sustained digital technology engagement.

Methods

This review will be based on the Arksey and O’Malley framework for scoping reviews. The 6-stage framework includes: identifying research questions, identifying relevant studies, study selection, charting the data, summarizing and reporting the results, and a consultation exercise. Published literature will be searched on primary electronic databases such as the Association of Computing Machinery, Web of Science, MEDLINE, PsycINFO, CINAHL, and ScienceDirect. Common grey literature sources will complement the database search on the topic. A two-stage (title/abstract and full article) screening will be conducted to obtain eligible studies for final inclusion. A standardized data extraction tool will be used to extract variables such as the profile of the study population, technologies under investigation, stage of digital engagement, and the barriers and facilitators. Identified and eligible studies will be analyzed using a quantitative (ie, frequency analysis) and qualitative (ie, content analysis) approach suitable for comparing and evaluating literature to provide an evaluation of the current state of the older person’s digital engagement. Inclusion will be based on the Joanna Briggs Institute–recommended participant, concept, and context framework. Articles on older people (65 years and older), on digital technology engagement, and from a global context will be included in our review.

Results

The results of this review are expected in July 2021.

Conclusions

The findings from this review will identify the extent and nature of empirical evidence on how older people digitally engage and the associated barriers and facilitators.

International Registered Report Identifier (IRRID)

PRR1-10.2196/25616
Utility, Value, and Benefits of Contemporary Personal Health Records: Integrative Review and Conceptual Synthesis (Preprint)
Authors: Ruhi Umar , Chugh Ritesh
Published: April 2021

BACKGROUND

Contemporary personal health record (PHR) technologies offer a useful platform for individuals to maintain a lifelong record of personally reported and clinically sourced data from various points of medical care.

OBJECTIVE

This paper presents an integrative review and synthesis of the extant literature on PHRs. This review draws upon multiple lenses of analysis and deliberates value perspectives of PHRs at the product, consumer, and industry levels.

METHODS

Academic databases were searched using multiple keywords related to PHRs for the years 2001-2020. Three research questions were formulated and used as selection criteria in our review of the extant literature relevant to our study.

RESULTS

We offer a high-level functional utility model of PHR features and functions. We also conceptualize a consumer value framework of PHRs, highlighting the applications of these technologies across various health care delivery activities. Finally, we provide a summary of the benefits of PHRs for various health care constituents, including consumers, providers, payors, and public health agencies.

CONCLUSIONS

PHR products offer a myriad of content-, connectivity-, and collaboration-based features and functions for their users. Although consumers benefit from the tools provided by PHR technologies, their overall value extends across the constituents of the health care delivery chain. Despite advances in technology, our literature review identifies a shortfall in the research addressing consumer value enabled by PHR tools. In addition to scholars and researchers, our literature review and proposed framework may be especially helpful for value analysis committees in the health care sector that are commissioned for the appraisal of innovative health information technologies such as PHRs.

CLINICALTRIAL
Knowledge About COVID-19 Among Adults in China: Cross-sectional Online Survey (Preprint)
Authors: Yu Fengyun , Geldsetzer Pascal , Meierkord Anne , Yang Juntao , Chen Qiushi , Jiao Lirui , Abou-Arraj Nadeem E , Pan An , Wang Chen , Bärnighausen Till , Chen Simiao
Published: April 2021

BACKGROUND

A detailed understanding of the public’s knowledge and perceptions of COVID-19 could inform governments’ public health actions in response to the pandemic.

OBJECTIVE

The aim of this study was to determine the knowledge and perceptions of COVID-19 among adults in China and its variation among provinces and by sociodemographic characteristics.

METHODS

Between May 8 and June 8, 2020, we conducted a cross-sectional online survey among adults in China who were registered with the private survey company KuRunData. We set a target sample size of 10,000 adults, aiming to sample 300-360 adults from each province in China. Participants were asked 25 questions that tested their knowledge about COVID-19, including measures to prevent infection, common symptoms, and recommended care-seeking behavior. We disaggregated responses by age; sex; education; province; household income; rural–urban residency; and whether or not a participant had a family member, friend, or acquaintance who they know to have been infected with SARS-CoV-2. All analyses used survey sampling weights.

RESULTS

There were 5079 men and 4921 women who completed the questionnaire and were included in the analysis. Out of 25 knowledge questions, participants answered a mean and median of 21.4 (95% CI 21.3-21.4) and 22 (IQR 20-23) questions correctly, respectively. A total of 83.4% (95% CI 82.7%-84.1%) of participants answered four-fifths or more of the questions correctly. For at least one of four ineffective prevention measures (using a hand dryer, regular nasal irrigation, gargling mouthwash, and taking antibiotics), 68.9% (95% CI 68.0%-69.8%) of participants answered that it was an effective method to prevent a SARS-CoV-2 infection. Although knowledge overall was similar across provinces, the percent of participants who answered the question on recommended care-seeking behavior correctly varied from 47.0% (95% CI 41.4%-52.7%) in Tibet to 87.5% (95% CI 84.1%-91.0%) in Beijing. Within provinces, participants who were male, were middle-aged, were residing in urban areas, and had higher household income tended to answer a higher proportion of the knowledge questions correctly.

CONCLUSIONS

This online study of individuals across China suggests that the majority of the population has good knowledge of COVID-19. However, a substantial proportion still holds misconceptions or incorrect beliefs about prevention methods and recommended health care–seeking behaviors, especially in rural areas and some less wealthy provinces in Western China. This study can inform the development of tailored public health policies and promotion campaigns by identifying knowledge areas for which misconceptions are comparatively common and provinces that have relatively low knowledge.
Immersive Virtual Reality Exergames for Persons Living With Dementia: User-Centered Design Study as a Multistakeholder Team During the COVID-19 Pandemic (Preprint)
Authors: Muñoz John , Mehrabi Samira , Li Yirou , Basharat Aysha , Middleton Laura E , Cao Shi , Barnett-Cowan Michael , Boger Jennifer
Published: April 2021

BACKGROUND

Advancements in supporting personalized health care and well-being using virtual reality (VR) have created opportunities to use immersive games to support a healthy lifestyle for persons living with dementia and mild cognitive impairment (MCI). Collaboratively designing exercise video games (exergames) as a multistakeholder team is fundamental to creating games that are attractive, effective, and accessible.

OBJECTIVE

This research extensively explores the use of human-centered design methods that involve persons living with dementia in long-term care facilitates, exercise professionals, content developers, game designers, and researchers in the creation of VR exergames targeting physical activity promotion for persons living with dementia/MCI.

METHODS

Conceptualization, collaborative design, and playtesting activities were carried out to design VR exergames to engage persons living with dementia in exercises to promote upper limb flexibility, strength, and aerobic endurance. We involved a total of 7 persons living with dementia/MCI, 5 exercise professionals, 5 community-dwelling older adults, a VR company for content creation, and a multidisciplinary research team with game designers, engineers, and kinesiology experts.

RESULTS

An immersive VR exergame called Seas the Day was jointly designed and developed and it is freely available to be played in state-of-the-art VR headsets (Oculus Quest 1, 2). A model for the triadic interaction (health care institution, industry partner, academia) is also presented to illustrate how different stakeholders contribute to the design of VR exergames that consider/complement complex needs, preferences, and motivators of an underrepresented group of end users.

CONCLUSIONS

This study provides evidence that a collaborative multistakeholder design results in more tailored and context-aware VR games for persons living with dementia. The insights and lessons learned from this research can be used by others to co-design games, including remote engagement techniques that were used during the COVID-19 pandemic.
Efectos de las medidas sanitarias COVID-19 en la acuacultura de la región noroeste de México
Authors: Torres Soto Nissa Yaing , Carrazco Escalante José Crisóforo , Rojas Méndez Daniel , Leyva León Eduardo
Published: April 2021

Objetivo: analizar el efecto de las medidas sanitarias ante el COVID-19 en la productividad acuícola de camarón blanco del pacífico.Diseño metodológico: se encuestó a un total de 102 gerentes de organizaciones, el promedio de edad de los encuestados fue de 45.4 años (DE=8.85), provenientes de granjas acuícolas del estado de Sinaloa, de los municipios de: Ahome, Guasave, Angostura, Navolato, Elota, Cospita, Culiacán, Mazatlán, El Rosario y Escuinapa. Para el análisis de resultados se probó un modelo de ecuaciones estructurales con el objetivo de probar el efecto de las medidas preventivas del COVID-19 en la productividad acuícola de camarón.Resultados: el análisis factorial confirmatorio (AFC) comprobó que las medidas preventivas ante el COVID-19 influyen positiva y significativamente en la productividad camaronícola. Las organizaciones, al adoptar medidas sanitarias no solo amortiguan el impacto negativo de la pandemia, sino también pueden estimular respuestas efectivas para el buen funcionamiento productivo.Limitaciones de la investigación: el tamaño de la muestra compuesta por las organizaciones estudiadas limita el alcance en la generalización de los resultados a gran escala, sin embargo, se puede recuperar ciertos datos para las organizaciones acuícolas de Sinaloa.Hallazgos: los sistemas agroalimentarios deben aprovechar la coyuntura que la COVID-19 está dejando a nivel mundial, ya que su óptimo funcionamiento coadyuvará no solamente al crecimiento de las organizaciones, sino también al desarrollo regional.