bluuebunny/crossref_metadata_2025 huggingface dataset:
Responses of naphthalene acetic acid and Pseudomonas inoculum on growth, yield and some biochemical parameters of sesame (Sesamum indicum L. var. BARI TIL-4)
Authors: Ema Shawline , Adam AMM Golam , Khan Farhana Islam , Begum Hasna Hena
Published: September 2020

An experiment was conducted to evaluate the responses of various concentrations of NAA (25, 50, 75 ppm) and Pseudomonas inoculum on growth, yield and some biochemical parameters of sesame (Sesamum indicum L. var. BARI Til-4). Results revealed that application of NAA treatments and Pseudomonas inoculum reduced plant height non-significantly. Significant result was recorded on number of branches per plants from 50 ppm NAA treated plants. Plants treated with 75 ppm NAA produced maximum number of leaves, fresh and dry weight of leaves and roots, leaf area per plant and specific leaf weight whereas significant variation was found on leaf area. Seeds treated with Pseudomonas inoculum exhibited maximum shoot and root ratio which showed non-significant variation with the results of NAA treated plants. Yield contributing parameters viz., number of pods per plant, fresh and dry weight of pods per plant, 1000-seed weight were recorded maximum from 75 ppm NAA which were statistically similar to control. Maximum length of pod and number of seeds per pod were also recorded from 75 ppm NAA treated plants which eventually produced 32.54% higher yield than control. Harvest index was significantly influenced by all the treatments. Foliar NAA treatments and Pseudomonas inoculum had stimulatory effects on pigment contents of fresh leaves at vegetative stage where, Pseudomonas inoculum treated plants produced significantly higher chlorophyll a and carotenoids content than control. Significantly higher protein content of fresh leaves and seeds were also recorded from 75 ppm NAA treated plants. Out of four treatments, 75 ppm NAA produced better responses in most of the parameters.
Addiktiot elämän tarkoituksena
Authors: Kurki Janne
Published: September 2020

Addiktioyhteiskunta : riippuvuus aikamme ilmiönä / Tuukka Tammi & Pauliina Raento (toim.). [Helsinki] : Gaudeamus, 2013.
Toimijuus elämänkulussa – ohjaustyön perusta?
Authors: Vanhalakka-Ruoho Marjatta
Published: September 2020

Toimijuutta tarkastellaan useimmiten yksilön suunnitelmina ja valintoina. Silloin ei tavoiteta sitä, miten ihmiset toimivat ja voivat toimia suhteissa tilanteisiin, toimintaympäristöiin, rakenteisiin ja aikakauteen.
KORELASI HEALTH BELIEF DENGAN KEPATUHAN PEMBATASAN CAIRAN DAN GARAM PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISA DI RUMAH SAKIT MURNI TEGUH MEDAN
Authors: Kasiman Kalvin Ginting Sutomo , Siregar Cholina Trisa
Published: September 2020

know that they suffer from a disease, they will take more serious care for their health and take medication in accordance with doctors’ recommendation. However, there are still many patients with CKD do not comply with the doctors’ recommendation. Health belief is the belief adhered in undergoing medication will affect the believers’ health. The objective of this research was to analyze the correlation of health belief  with fluid and salt restriction compliance in patients with CKD undergoing hemodialysis. This research employed quantitative design with cross sectional method. There were 150 patients with CKD undergoing hemodialysis in total that were taken as the samples. This research was conducted at Murni Teguh Hospital, Medan. The samples were selected by applying total accidental technique. The data were collected through questionnaires, and the analysis was made by using Pearson  test. The results of Pearson test on the correlation of health belief  with patients’ fluid and salt restriction compliance demonstrated value of p = 0.000. It indicated that health belief are correlated with the fluid and salt restriction compliance of patients with CKD undergoing hemodialysis. It is recommended that nurses improve their education quality and frequency by paying attention to patients.
GI support of geological exploration of non-ferrous metal ore deposits
Authors: Mammedov Аlesger , Musaev Shahbeddin , Poshivaylo Yaroslava , Fedotov Grigory
Published: September 2020

Geoinformation technologies are applied, without exaggeration, in all spheres of human activity, and the geological industry is no exception. Geoinformation systems in geology help to solve a number of practical problems. Geologists specializing in mineral exploration use a variety of data sets to search for new, cost-effective deposits, from geological maps, hyperspectral aerial photographs and multispectral satellite imagery to databases of various formats. The geographic information system is an ideal platform for combining such heterogeneous information and its subsequent analysis.

The article describes the experience of the national mining company of the Republic of Azerbaijan CJSC AzerGold in the use of geographic information systems in the exploration of non-ferrous metal deposits using the example of the development of the Filizchay and Aghyokhush deposits. The authors considered production problems, described the problems that arise at the stage of exploration and proposed methods for solving them, the need for the integrated use of information systems in exploration when searching for deposits of non-ferrous metals is noted. A database structure has been developed for the purpose of geological exploration of non-ferrous metal ores, including sections such as topography, geochemistry, geophysics, structural geology. The structure of geoinformation support for geological exploration of non-ferrous metal ores is proposed, which combines the functionality of geographic information systems (GIS) and mining geological information systems (MGIS).

The stages of geoinformation processing of initial data are illustrated, on the basis of which a geological exploration strategy was formed at the Filizchay pyrite-polymetallic deposit, and then the optimal places and number of wells, coordinates, directions and angles of incidence of wells were determined quickly and with high accuracy, as well as the resource potential was specified. The role of interpolation methods in determining the primary exploration wells in the exploration of the Agyokhush gold deposit is disclosed.
Research of migration of technogenic bottom sediments with application of modern geoinformation systems
Authors: Maksimovich Nikolay , Berezina Olga , Meshcheriakova Olga , Demenev Artem
Published: September 2020

The study of the regularities of formation and migration of technogenic bottom sediments in river ecosystems of mining regions is an urgent area of works of domestic and foreign researchers in connection with the high need to reduce the anthropogenic impact on the natural components of the environment. This article is devoted to the problems of the migration of pollutants and the formation of technogenic bottom sediments in river ecosystems in the Kizel coal basin (Perm Region, Russia). The scale of the problem is determined by the existence of numerous sources containing extremely high concentrations of elements of the 1st, 2nd and 3rd hazard classes.

The main sources of contaminants on the study area are acid mine waters discharged through former mines and springs, as well as effluents from waste dumps. These technogenic solutions are characterized by a multicomponent composition, in which high concentrations of the following elements (Fe, Al, Mn, Zn, Be, Cu, Pb, Cd et al.) are noted. Exceeding the MPC for some elements reaches hundreds and thousands of times; in all, according to various estimates, over 500 km of rivers are polluted in the territory of the former Kizel coal basin and in the zone of its influence.

The article describes the characteristics of bottom sediments of the river Kos’va, one of the largest regional rivers, according to long-term observations from 1984–2018, field studies, as well as the use of GIS technologies and the created geo-ecological geoinformation system of the Kizel coal basin. Also, based on international experience, environmental measures were proposed to restore the river ecosystems of the territory.
Depth of the relief dissection on the territory of the Crimean Peninsula
Authors: Tabunshchik Vladimir
Published: September 2020

The Crimean Peninsula is a unique natural area that combines both mountain and flat terrain. However, the characteristics of the relief of the Crimean Peninsula in most cases are limited only to a qualitative assessment. In the article, the relief of the Crimean Peninsula is measured and a map of depth of the relief dissection of the Crimean Peninsula is constructed. Methods of constructing such maps using modern methods of geoinformatics and open geodata — digital terrain model Shuttle Radar Topographic Mission (SRTM) are discussed. On the basis of the methodology for the territory of the Crimean Peninsula, a map of depth of the relief dissection is constructed. The values of the indicator of depth of the relief dissection of the Crimean Peninsula range from 0 to 790 m per km2. Average value of the depth of the relief dissection of the Crimean Peninsula is 46 m per km2. Geographically, the indicator of the depth of the relief dissection of the Crimean Peninsula is distributed irregularly. On the territory of the Crimean Peninsula, value the depth of the relief dissection are 50 m per km2 (80 % of the total area) prevail, which is due to the fact that most of the peninsula has a flat terrain. The highest indicator values of the depth of the relief dissection is typical for the southwestern part of the Crimean Peninsula, where there are the greatest differences in elevation between yailas (Ai-Petri yaila, Yalta yaila, Gurzuf yaila, Nikita yaila, Babugan-Yaila) and slopes steeply down to the southern coast of Crimea. In addition, the distribution of the terrain depth index for landscape levels on the territory of the Crimean Peninsula was analyzed: the minimum, maximum, and average values of the of the depth of the relief dissection of the Crimean Peninsula and landscape level of the Crimean Peninsula were determined.
INTERNALISASI NILAI-NILAI MULTIKULTURAL DALAM PROSES PEMBELAJARAN PAI DI SMA DARUT TAQWA, PASURUAN
Authors: Makhfud Syawaludin
Published: September 2020

This research explains the internalization of multicultural values ​​in the learning process of PAI at Senior high school Darut Taqwa Sengonagung Purwosari Pasuruan. This Research uses a qualitative approach with the type of case study. The data collection was through by unstructured and opened interview techniques, unattended and opened observation, and documentation techniques. For analysis and interpretation of data using steps: a). Reduction data, b). Displaying data, and c). Conclusion drawing / verification. The results of the research shows that the internalization of multicultural values ​​in the learning process of PAI through two ways, namely through the material and using methods that reflect multicultural values.
Gender of internal medicine resident impacts cancer preventive care for women
Authors: Hefley Shyanne , L Vasylyeva Tetyana , Salguero Maria , Al-Humaish Saif , Cutts Karen , Smalligan Roger
Published: September 2020

Mammography and cervical screening are effective methods for early cancer detection in women. Recent reports showed that 69% of women ³45 years had a mammogram in the past 2 years and 16-55% of women had a Pap smear regularly. Internal medicine (IM) physicians are crucial players in women's health management and literature has identified that a physician’s gender impacts patient management in many areas of healthcare.

 We investigated mammogram and Pap smear recommendations by IM residents and examined differences in approaching women’s health issues between female and male residents. With IRB approval, one-hundred charts of new female patients were reviewed, which included female patients 45 years or older seen by IM residents for their first visit. All patients completed a questionnaire concerning previous medical conditions and care as part of clinic routine. Patient chart information, recommendations for mammogram and cervical cancer screening by the resident were recorded, along with the gender of the resident and supervising attending.

 The mean age of the patients was 61±9.3 years. Female residents were more likely to recommend a mammogram compared to male residents (36.7% and 16.4%, respectively).  No significant differences in Pap smear recommendations were observed between female and male residents (9.3% and 10.1%, respectively). Attending physician’s gender did not influence screening recommendations.

 The recommendation rate for female patients to obtain important screening mammograms and Pap smears was low. These results are consistent with previous literature and indicate an urgent need for improved women’s health education in residency, with special attention to male residents.

 

Keywords: Cancer prevention, Breast cancer, Cervical Cancer, Primary Care, Gender Disparity
ECOTOXICOLOGICAL EVALUATION OF GRAIN PRODUCTS OF AGROCENOSIS ON THE CONTENT OF PESTICIDAL RESIDUES UNDER CONDITIONS OF THE FOREST RIVER STEPPE
Authors: Yakovets Liudmyla
Published: September 2020

The article presents the results of ecotoxicological assessment of grain production of agrocenosis according to the content of organochlorine pesticides. The aim of the research is the ecotoxicological assessment of the grain production of agrocenoses by the content of pesticide residues in the conditions of the forest-steppe right-bank. Field studies were conducted on the territory of agricultural enterprises of Shargorodsky, Peschansky and Kalinovsky districts of Vinnitsa region, located in the forest-steppe right-bank. Laboratory analyzes of soil, grain and seeds of field crops of agroecosystems were carried out in certified laboratories (Scientific-measuring agrochemical laboratory of Vinnitsa National Agrarian University and the laboratory of the testing center of Vinnitsa branch of the State Institution «Soil Protection Institute of Ukraine»). The studies determined the danger of contamination of grain products of agrocenosis with pesticides and their negative impact on the soil-plant system.
The research results showed that due to the resource-saving level of chemicalization when growing field crops, the average humus content in the soils of right-bank forest-steppe agroecosystems was 2.3−3.4 %, nitrogen, which is easily hydrolyzed − 63.0-77.0 mg/kg, mobile phosphorus − 120-180 mg/kg, exchange potassium − 68-94 mg/kg, while the hydrolytic acidity was 2.5-3.5 mg. equiv. / 100 g of soil and pH (salt) − 5.0-7.2. The agrochemical parameters of soils of agroecosystems, where intensive levels of chemicalization of agriculture are used, the elemental content, in particular in the available forms of nitrogen, phosphorus and potassium, was 1.4-1.6 times higher, but the hydrolytic acidity was almost halved and the soil pH increased.
It was found that when growing winter wheat using resource-saving technologies, the pesticides load per 1 ha of agroecosystem is 3.53 l/ha, and for intensive technologies – 4.73 l/ha.
When growing spring barley, respectively, 3.53 l/ha and 4.03 l/ha, and corn - 0 and 0.85 l/ha. In general, the cultivation of winter wheat by intensive technologies causes an increase in pesticides load per 1 ha of agroecosystem by 25.4 % compared to resource-saving technology, the cultivation of spring barley by 12.4 %, and corn by 98.8 %.
It was established that in the forest ecosystems of the right-bank steppe at different levels of chemicalization of agriculture, the actual fluctuations in the agrochemical parameters of the soil depended on the field and predecessor crop rotation, and the content of organochlorine pesticide residues differed within the error and did not exceed their maximum permissible concentrations. The content of residual trace amounts of γ - HCH in the grain and seeds of the studied cultures was less than 0.02 mg/kg with a MPC of 0.5 mg/kg, DDT − less than 0.02 mg/kg with a MPC of 0.2 mg/kg.
Key words: grain products, pesticides, organochlorine pesticides, agrocenosis, pollution.
THE INVESTIGATION OF THE UNIVERSITY STUDENTS’ SELF-DISCLOSURE BEHAVIORS IN TERMS OF PERSONALITY TRAITS AND IDENTITY PROCESESS
Authors: BEDİR Yunus , ATA Denis , SÜDEMEN Merve , ŞENER Ahmet Taner , MORSÜNBÜL Ümit
Published: September 2020

Healthy interpersonal communication’s establishing and sustaining depend on using variety communication skills’ effective. Self-disclosure provides people to establish more satisfying and healthy relationships that from this one of the communication skills. The aim of this study that to determine how personality traits and identity dimensions predict university students' self-disclosure behavior. Research group consist of 282 university students (% 67.4 female, % 32.6 male). The Pearson correlation and regression model were used in the analysis of the data. According to findings, extroverted personality predicted significantly the amount of self-disclosure, self-compliance, extroversion, responsibility, emotional balance honesty predicted; It was concluded that it predicted the experience significantly. Furthermore, it has significantly predicted integrity research and obsessive research honesty from identity development dimensions; however, it was concluded that attachment, attachment identification and in-depth research did not predict.
ÇAĞRI MERKEZLERİNE GÜNCEL BİR BAKIŞ: BANKACILIK SEKTÖRÜ ÜZERİNE BİR ARAŞTIRMA
Authors: ÖZBEK Tülay
Published: September 2020

Teknolojinin ilerlemesiyle birlikte her geçen gün değişen pazar koşulları ve eğilimleri ile özellikle son yılların en önemli olgusu olan müşteriler, işletmelerin de yeni uygulamalar ile hizmet sunmasını gerekli kılmıştır. Özellikle günümüzde rekabetin artması ve giderek daha zorlu hale gelmesi, müşteri bağlılığına her zamankinden daha fazla önem verilmesiyle, müşterilerine etkin bir şekilde ulaşıp iletişim kurmak isteyen işletmelerin “Çağrı Merkezleri” uygulamalarına olan ilgilerinin arttığı ve daha yoğun bir şekilde kullanmaya başladıkları görülmektedir. Çağrı merkezleri pek çok işletme de olduğu gibi bankacılık sektöründe de stratejik olarak önemli olup, bu sektörde yaygın olarak kullanılmaktadır. Bu çalışma ile, Türkiye Bankalar Birliği (TBB) üyesi bankaların çağrı merkezleri verilerinin yayınlanmaya başladığı ilk yıldan (2008) itibaren 2019 yılına kadar değişimlerinin incelenmesi amaçlanmıştır. Ayrıca çağrı merkezleri kavramı, çağrı merkezleri müşteri temas biçimleri kavramsal olarak açıklanmıştır. Söz konusu çalışma ile TBB üyesi bankaların çağrı merkezleri hizmetlerine ilişkin mevcut durumları ortaya çıkarılmaya çalışılmıştır. Sonuç olarak, çağrı merkezleri hizmetlerinin bankacılık sektöründe pazar payı giderek artmaktadır. Ayrıca bankacılık sektörü çağrı merkezleri her geçen gün fonksiyonlarına yenilerini ekleyerek uygulamalarını artırmakta ve farklı kanallardan hizmet verme yarışı içerisine girmektedirler.
L’Alsace dans la Grande Guerre
Authors: Grandhomme Jean-Noël
Published: September 2020

En 2013, un siècle après l’affaire de Saverne – qui apparaît rétrospectivement comme une sorte de prologue de la Grande Guerre –, un groupe d’historiens confirmés et de jeunes chercheurs entend faire le point sur l’état des connaissances concernant un conflit qui a eu une importance toute particulière pour l’Alsace. Événements militaires, mais aussi politiques, économiques, sociaux, vie quotidienne des soldats et des civils seront évoqués tour à tour dans ce volume. La question de la mémoire et des enseignements à tirer du conflit ne sera pas oubliées non plus.
The debate regarding the number of company cars in Belgium
Authors: May Xavier
Published: September 2020

Many different figures are mentioned regarding the number of company cars in Belgium. A definition is adopted and two types of beneficiary are identified. However, the analysis of official statistics shows that no source allows us to determine the number of company cars in Belgium, although it is certain that their numbers have increased rapidly over the past decade. An attempt to quantify the number of vehicles concerned is carried out as well as a mapping of the places of residence of beneficiaries for all districts...
Profils des entreprises utilisatrices de voitures de société en Région de Bruxelles-Capitale
Authors: Ermans Thomas
Published: September 2020

Sur base des données des Plans de déplacements d’entreprise de la RBC (2014), nous avons mis en évidence trois profils d’entreprises utilisatrices de voitures de société. Ces dernières sont définies comme l’ensemble des entreprises avec au-moins 10 voitures de société pour 100 travailleurs, un seuil qui exclut la quasi-totalité des administrations publiques ainsi que les secteurs de la santé et de l’enseignement. Au-delà de l’élaboration de profils particuliers, cette factsheet met en évidence le rapport de corrélation, d’association, entre la mise à disposition de voitures de société au bénéfice des travailleurs et d’autres caractéristiques. Spécifiquement, le recours aux voitures de société concourt, avec une mise à disposition généreuse de places de parking et une mauvaise accessibilité en transports en commun, à dessiner des profils de mobilité à l'échelle de l’entreprise globalement tournés vers l’usage du mode automobile sur les déplacements domicile-travail.
Remarques sur la création plurilingue chez Fernando Pessoa
Authors: Dionísio João
Published: September 2020

L’observation du fonds Fernando Pessoa (1888-1935) à la Bibliothèque nationale du Portugal permet de mettre en évidence deux types de recours à d’autres systèmes linguistiques que la langue maternelle de l’écrivain portugais (1888-1935) : 1) annotations métadiscursives, inclusivement des indications de création littéraire, dont un nombre significatif en anglais ; 2) l’abandon de la langue dans laquelle il commence à écrire un texte (l’anglais ou le français, langues occasionnelles d’inspiration initiale) pour continuer en portugais. Ce type de bilinguisme manifeste dans le processus créatif est mis en rapport avec la vision idéaliste que Pessoa a de la poésie, qui, selon lui, « doit être composée et exprimée dans une langue quelconque », comme si toute création littéraire était le résultat de la traduction du langage de l’esprit vers une langue naturelle.
112’DE GÖREV YAPAN SAĞLIK PERSONELİNİN ÇOCUK İHMAL VE İSTİSMARINA YÖNELİK FARKINDALIK DÜZEYLERİ: ANKARA ÖRNEĞİ
Authors: ŞAN İshak , BEKGÖZ Burak , ULUCAN ÖZKAN Elvan
Published: September 2020

Hizmetlerinde görev yapan sağlık personelinin konuya ilişkin bilgi düzeylerini ve farkındalıklarını değerlendirmeyi amaçlamaktadır. Yöntem: araştırma nicel yöntem ve tarama modelinde tasarlanmıştır. Araştırmaya Ankara 112 İl Ambulans Servisi Başhekimliğinde çalışan sağlık personelinin tümü dahil edilmiş, 74 ATT, 41 Paramedik, 11 Hemşire/Ebe/Sağlık Memuru ve 8 Doktor olmak üzere toplam 135 kişiye ulaşılmıştır. Araştırmada sosyo-demografik veri formu ve ‟Çocuk İstismarı ve İhmalinin Belirti ve Risklerinin Tanılanması‟na yönelik geliştirilen anket formu kullanılmıştır. Elektronik form ile toplanan verilerde Shapiro Wilks, ki-kare, Mann Whitney U ve Kruskal Wallis testi kullanılmıştır. Bulgular: Evli olanların çocuk istismarına ilişkin çocuktaki davranışsal belirtileri tanılama, lise ve ön lisans eğitimini tamamlamış olanların çocuk istismarına ilişkin çocuktaki fiziksel belirtileri tanılama ve Komuta Kontrol Merkezinde çalışanlarının ihmalin çocuk üzerindeki belirtilerini tanılamaya dair puan ortalaması daha yüksek bulunmuştur. Sonuç: Bu çalışma sonucunda 112 çalışanlarının çocuk istismarı ve ihmali konusundaki farkındalıklarının yeterli düzeyde olmadığı görülmüştür.
UNIVERSALIDADE DOS DIREITOS SOCIAIS EM TEMPO DE PANDEMIA
Authors: Carvalho Augusto César Leite de , Carvalho João Vítor Barros de
Published: September 2020

Este ensaio trata da relevância de o discurso jurídico associar a categorização dos direitos humanos como direitos subjetivos à possibilidade de todos os direitos promocionais, com ênfase para os direitos sociais e para aqueles que remetem ao desenvolvimento humano sustentável, serem exigíveis como políticas públicas que pressupõem, na norma jurídica, mais que um conteúdo meramente programático.
An Experimental Research on the Integration of Ideal and Belief Education into English Major Courses in Chinese UniversitiesAn Experimental Research on the Integration of Ideal and Belief Education into English Major Courses in Chinese Universities
Authors: Feng Yang
Published: September 2020

The university phase is a critical period for the formation of students' outlook on life and career ideals, but some Chinese college students lack a correct understanding and motivation for learning, which needs to be improved. Through a teaching reform experiment to integrate ideal and belief education in the professional course in an academic year and 32 teaching weeks to 106 freshmen and 113 sophomores of English education majors. The result shows that compared with the control group who maintained the conventional teaching mode, the experimental group’s performance in the outlook on life, academic development plans, professional ideals, and their motivation to learn well are all significantly improved, and the final exam scores have increased by 13-15% on average. The experiment shows that the use of appropriate materials and methods to integrate ideal and belief education in the teaching of professional courses in college can effectively promote students to form a correct outlook on life and career planning, improve learning enthusiasm and professional course performance, and help serve the society to achieve their ideals in life.
Mechanistic Studies on Propargyl Alcohol‐Tethered Alkylidenecyclopropane with Aryldiazonium Salt Initiated by Visible Light
Authors: Liu Jiaxin , Wei Yin , Shi Min
Published: September 2020

Main observation and conclusion

This paper discloses the reaction mechanism of two consecutive but different visible light photo‐induced chain processes for the rapid construction of spirobi[indene] skeletons. The first process is triggered by a photo‐induced single‐electron‐transfer (SET) of an electron donor‐accepter (EDA) complex. The second process is initiated by a direct SET process between aryldiazonium salt and the excited allenic intermediate. In these two processes, another SET took place respectively on the in situ formed radical intermediate to realize a redox‐neutral outcome. The mechanistic studies have been carried out by control experiments, kinetic and spectroscopic analyses, deuterium labeling experiments to support these two chain processes.
Inviscid Limit of Vorticity Distributions in the Yudovich Class
Authors: Constantin Peter , Drivas Theodore D. , Elgindi Tarek M.
Published: September 2020

We prove that given initial data , forcing and any T > 0, the solutions uν of Navier‐Stokes converge strongly in for any p ∈ [1, ∞) to the unique Yudovich weak solution u of the Euler equations. A consequence is that vorticity distribution functions converge to their inviscid counterparts. As a by‐product of the proof, we establish continuity of the Euler solution map for Yudovich solutions in the Lp vorticity topology. The main tool in these proofs is a uniformly controlled loss of regularity property of the linear transport by Yudovich solutions. Our results provide a partial foundation for the Miller‐Robert statistical equilibrium theory of vortices as it applies to slightly viscous fluids. © 2020 Wiley Periodicals LLC.
Applicability of Chromatographic Co‐Elution for Antibiotic Target Identification
Authors: Schäkermann Sina , Wüllner Dominik , Yayci Abdulkadir , Emili Andrew , Bandow Julia Elisabeth
Published: September 2020

Identification of the molecular target is a crucial step in evaluating novel antibiotics. To support target identification, a label‐free method based on chromatographic co‐elution has previously been developed. Target identification by chromatographic coelution (TICC) exploits the alteration of the elution profile of target‐bound drug versus free drug in ion exchange (IEX) chromatography to identify potential target proteins from elution fractions. The applicability of TICC for antibiotic research is investigated by evaluating which proteins, that is, putative targets, can be monitored in Bacillus subtilis. Coelution of components of known protein complexes provides a read‐out for how well the native state of proteins is conserved during chromatography. Rifampicin, which targets RNA polymerase, is used in a proof‐of‐concept study.
Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis
Authors: Xu Ying , Wang Qian , Li Xiaozhen , Chen Yingyan , Xu Gang
Published: September 2020

Radiotherapy is a common therapy method for nasopharyngeal carcinoma (NPC) treatment; however, radioresistance greatly limits the clinical efficiency and prognosis of NPC patients. Therefore, it is extremely urgent to reveal the underlying mechanism contributing to radioresistance and find possible diagnostic biomarkers. Here, we collected the spheroids formed by NPC cells, which had been confirmed to hold the stem cell‐like traits, and found that these spheroids exhibited a certain degree of radioresistance. Additionally, NPC spheroids displayed a certain degree of ferroptosis resistance, as evident by the decrease of iron concentration in lysosomes and lipid peroxides oxygen, and increase of glutathione (GSH) level. Furthermore, we revealed that itraconazole triggered the ferroptosis of NPC spheroids, which is characterized as the increase of iron concentration and lipid peroxides oxygen, and decrease of GSH level, and decreased the cell viability of NPC spheroids. Notably, itraconazole partially reversed the radioresistance of NPC spheroids. Mechanistically, we found that itraconazole can sequester iron in lysosome and thus trigger ferroptosis; this is essential for itraconazole‐mediated attenuation on NPC spheroid stemness. Therefore, this study provides evidences showing that itraconazole might be used for killing NPC stem cells and thus attenuate radioresistance.
Uncovering the ecology of clinical education: a dramaturgical study of informal learning in clinical teams
Authors: Cantillon Peter , De Grave Willem , Dornan Tim
Published: September 2020

Off-the-job faculty development for clinical teachers has been blighted by poor attendance, unsatisfactory sustainability, and weak impact. The faculty development literature has attributed these problems to the marginalisation of the clinical teacher role in host institutions. By focusing on macro-organisational factors, faculty development is ignoring the how clinical teachers are shaped by their everyday participation in micro-organisations such as clinical teams. We set out to explore how the roles of clinical teacher and graduate learner are co-constructed in the context of everyday work in clinical teams. Using an ethnographic study design we carried out marginal participant observation of four different hospital clinical teams. We assembled a dataset comprising field notes, participant interviews, images, and video, which captured day-to-day working and learning encounters between team members. We applied the dramaturgical sensitising concepts of impression management and face work to a thematic analysis of the dataset. We found that learning in clinical teams was largely informal. Clinical teachers modelled, but rarely articulated, an implicit curriculum of norms, standards and expectations. Trainees sought to establish legitimacy and credibility for themselves by creating impressions of being able to recognise and reproduce lead clinicians’ standards. Teachers and trainees colluded in using face work strategies to sustain favourable impressions but, in so doing, diminished learning opportunities and undermined educational dialogue. These finding suggest that there is a complex interrelationship between membership of clinical teams and clinical learning. The implication for faculty development is that it needs to move beyond its current emphasis on the structuring effects of institutional context to a deeper consideration of how teacher and learner roles are co-constructed in clinical teams.
Does Sea Surface Temperature Affect Solubility of Iron in Mineral Dust? The Gulf of California as a Case Study
Authors: Félix‐Bermúdez Armando , Delgadillo‐Hinojosa Francisco , Torres‐Delgado Eunise V. , Muñoz‐Barbosa Albino
Published: September 2020

Eolian transport of mineral dust is one of the main inputs of iron (Fe) to the global ocean; however, the magnitude and biogeochemical impact of this supply depends on the solubility of the deposited dust. In particular, the effect of temperature on Fe‐bearing dust solubility has been scarcely investigated even though a seasonal gradient of sea surface temperature (SST) is a common feature in coastal zones adjacent to the major dust source regions of the world. In this work, the effect of temperature on the fractional solubility of Fe (FFeS) was evaluated experimentally using sieved soils (as a dust proxy) from the Baja California Peninsula and surface seawater from the Gulf of California (GC). Two incubations were performed at 17°C (winter) and 29°C (summer) considering the seasonal variability of SST in the GC. Differences in FFeS up to 3 orders of magnitude (0.003–4.49%) were linked to incubation temperature, dust load, and contact time between seawater and dust. After 72 hr of incubation, the effect of temperature was statistically significant (p < 0.05) for all dust treatments, with FFeS higher (4–24 times) at 29°C. High FFeS in warmer waters are a result of increased Fe‐bearing dust dissolution and decreased scavenging of Fe by dust particles. Since temperature appears to control the magnitude of FFeS in the GC, we suggest that this factor could have an effect on the atmospheric inputs of soluble Fe in marginal seas with similar seasonal SST contrasts; including the global ocean, where well‐defined latitudinal temperature gradients exist.
Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion
Authors: Hwang Kyungmin , Seo Yeong-Hyeon , Kim Daniel Y. , Ahn Jinhyo , Lee Soyoung , Han Kyung Hee , Lee Koun-Hee , Jon Sangyong , Kim Pilhan , Yu Kate E. , Kim Hyungsin , Kang Shin-Hyuk , Jeong Ki-Hun
Published: September 2020

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular level. Here, we report a fully packaged handheld confocal endomicroscopic system for real-time, high-resolution, and in vivo cellular imaging using a Lissajous scanning fiber-optic harmonograph. The endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph, a confocal microscope unit, and an image signal processor. The fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube, which resonantly scans both axes at ~ 1 kHz to obtain a Lissajous pattern. The fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective lens. The endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical endoscope. The probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous scanning. The signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber scanners. The confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.
A Nursing Perspective on Infant Bed-Sharing Using Multidisciplinary Theory Integration
Authors: Bunch Marissa G. , Hutson Sadie P.
Published: September 2020

The American Academy of Pediatrics recommends against bed-sharing between infants and caregivers due to an association with suffocation. Caregivers continue to share a bed with their infant despite these recommendations for a multitude of reasons. A close examination of the bed-sharing literature reveals that the debate is fundamentally about theoretical differences. The major theories used to frame this problem include the triple risk model of bed-sharing and evolutionary theories. Nurses are masters of multidisciplinary collaboration and are well positioned to unify the triple risk and evolutionary views of infant bed-sharing to guide future innovations in health care practice and research.
PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
Authors: Dounce Susan M. , Laskina Olga , Goldberg Roger A.
Published: September 2020

Background:

Syringes containing anti-vascular endothelial growth factor drugs to treat retinal diseases are prepared in different ways by various parties with syringe selection, preparation, and storage conditions affecting the risk of injecting particles into the vitreous. This study examines particle loads from various syringes over time.

Methods:

Four syringes were studied: two plastic transfer syringes lubricated with silicone oil or oleamide, a glass syringe with baked-on silicone, and a lubricant-free polymer syringe. Syringes were rinsed with water or filled with buffer and analyzed over time; particles were quantified by flow imaging. Particle formation in a bevacizumab formulation was also characterized.

Results:

Insulin syringes consistently showed very high particle counts. Oleamide-lubricated syringes had substantially fewer particles, but showed appreciable increases over time (leading to visible particles). Baked-on silicone glass syringes and lubricant-free polymer syringes both showed low particle levels ≥10 μm. Lubricant-free syringes showed the lowest particle levels ≥1 μm and the lowest particle levels with bevacizumab agitation.

Conclusion:

Syringes have different intrinsic particle loads which can contribute to particle loads in the delivered drug. Oleamide-lubricated transfer syringes, commonly used for bevacizumab repackaging, have time-dependent particle loads and are associated with the formation of visible particles beyond 30 days of storage.
Efficiency of azathioprine monotherapy for maintenance treatment of autoimmune hepatitis in children
Authors: Aksoy Betul , Baran Masallah , Cagan Appak Yeliz , Sag Elif , Cakir Murat , Guven Burcu , Yavuz Sibel , Emir Busra , Tumgor Gokhan
Published: September 2020

Introduction

Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission is usually maintained with low dose prednisolone and azathioprine (AZA). The aim of this study is to evaluate the efficiency of AZA monotherapy for maintenance treatment of children with AIH.

Materials and methods

This study was a retrospective analysis of the 55 children with AIH. Patients were divided into two groups: combination therapy (CT) and AZA group based on maintenance therapy. Results of these two different maintenance treatments were compared in children with AIH.

Results

The mean age of the children was 10.67 ± 4.30 years (61.8% females) with a mean follow-up period of 46.8 ± 33.6 months. For maintenance treatment, 39 (70.9%) patients received AZA and 16 (29.1%) patients received CT. Relapse was observed in nine (19.6%) cases in the follow-up period; two were in the CT group (2/16; 12.5%) and seven (7/39; 17.9%) were in the AZA group (P = 0.620). In AZA group, the duration of remission was 22.2 ± 6.1 months and that was longer than CT group (P = 0.025).

Conclusion

Our study suggests that AZA monotherapy is an effective and safe therapy for maintaining remission in children with AIH. AZA monotherapy may be used for maintenance treatment of children with AIH, except in cases of overlap syndrome and also to avoid side effects of long-term used steroids and to improve treatment compliance in proper cases.
Psychological defense mechanisms and use of corporeal discourse: a comparison between patients with irritable bowel syndrome, medical personnel and healthy volunteers
Authors: Reicher-Atir Rebecca , Avnat-Becker Lee , Levy Sigal , Sperber Ami D. , Dickman Ram
Published: September 2020

Objective

The aim of this study was to compare the use of psychological defense mechanisms and corporeal discourse among patients with irritable bowel syndrome (IBS), medical personnel and healthy volunteers.

Methods

All participants completed an identical battery of questionnaires: a demographic questionnaire, the Corporeal Discourse Questionnaire, the Defense Style Questionnaire and a Visual Analogue Scale for situational anxiety and depression. Patients and medical personnel were recruited from the Rabin Medical Center, a tertiary university-affiliated hospital. Findings were analyzed according to the study variables and compared among the groups.

Results

Questionnaires were completed by 40 patients with IBS, 39 medical personnel and 40 healthy volunteers. Correlations between the study variables within the entire study group (all study participants, N = 119) revealed that corporeal discourse was found to be significantly correlated with the immature and neurotic class of defense mechanisms (r = 0.41, P < 0.01 and r = 0.20, P < 0.05, respectively), depression (r = 0.46, P < 0.05) and anxiety (r = 0.46, P < 0.05). Differences between IBS and the other two groups were significant for corporeal discourse, depression, anxiety and use of immature defense mechanisms. Posthoc analyses showed that medical personnel differed from IBS patients in all of these measures. Healthy volunteers had an inconsistent pattern of differences from the other two groups.

Conclusion

Maturity level of defense mechanisms and the tendency to use corporeal discourse are expressed among IBS patients in a diverse and unique manner. These findings may indicate additional psychological mechanisms that could explain the use of somatic complaints in IBS and support the implementation of tailored psychological interventions.
Reconstruction of Craniofacial Skin Cancer Resection Defect in Octogenarian Patients Using Fenestrated-type Artificial Dermis Without Skin Grafting
Authors: Chicco Maria , Cheng Hsu-Tang
Published: September 2020

Reconstructive surgery following skin cancer resection in octogenarian patients can be challenging. Despite current advancements in reconstructive options, most of these wide excision defects require local or even free flap coverage, causing physical and emotional impairment. Few reports have been published on the management of these complex craniofacial defects. We present our experience in 2 octogenarian patients with craniofacial skin cancer treated with wide excision under wide-wake local anesthesia and subsequently reconstructed with fenestrated-type artificial dermis. Both patients had uneventful recovery. The wounds healed by secondary intention without skin grafting.
Fibromyalgia in patients with psoriatic arthritis: Relationship with enthesopathy, sleep, fatigue and quality of life
Authors: Ulutatar Firat , Unal‐Ulutatar Cagri , Tuncay Duruoz Mehmet
Published: September 2020

Objectives

To evaluate the relationship of fibromyalgia with enthesopathy, sleep, fatigue and quality of life in patients with psoriatic arthritis.

Methods

The psoriatic arthritis patients according to CASPAR criteria were included in the study. The diagnosis of fibromyalgia was based on 2016 ACR criteria. Demographic and clinical parameters were noted. Disease activity and enthesopathy were evaluated with Disease Activity Score‐28 (DAS‐28) and Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), respectively. Functional assessment scales in this study were Psoriatic Arthritis Quality of Life (PsAQoL), Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue (MAF). Fibromyalgia Impact Questionnaire (FIQ) was used to assess the functional status of fibromyalgia. The Mann‐Whitney U test and Spearman correlation coefficient (ρ) were used. Hierarchical multiple regression analysis used to examine the differential contributions to FIQ score. P < .05 was accepted as significant.

Results

We enrolled 50 PsA patients (31 female, 19 male) with a mean age of 49.5 years (SD: 10.2) and mean disease duration 7.5 years (SD: 7.5). Thirty‐two patients (64% of PsA patients) fulfilled ACR criteria for fibromyalgia. The mean scores of MASES, PSQI, MAF and PsAQoL were significantly higher in patients with fibromyalgia (P < .05). The correlations between FIQ and other functional parameters were as follows; MASES (ρ = 0.71, P < .0005), PSQI (ρ = 0.62, P < .0005), MAF (ρ = 0.60, P < .0005), PsAQoL (ρ = 0.61, P < .0005). A moderate correlation was existing between FIQ and DAS‐28 (ρ = 0.42, P = .03).

Conclusions

Coexistence of fibromyalgia in PsA patients is associated with the presence of enthesopathy, poor quality of life, sleep disturbance and fatigue.
Frequency of laboratory testing and associated abnormalities in patients with hypertension
Authors: Quan Samuel , Chen Guanmin , Padwal Raj S. , McAlister Finlay A. , Tran Karen C. , Campbell Norman R. C. , Liang Zhiying , Feng Yuanchao , Rabi Doreen M. , Leung Alexander A. ,   for Hypertension Canada’s Research, Evaluation Committee
Published: September 2020

Clinical practice guidelines recommend several routine laboratory tests in patients diagnosed with hypertension. However, the rates of clinically relevant laboratory abnormalities are unknown. Therefore, we conducted a retrospective cohort study using administrative and laboratory data of patients diagnosed with hypertension between April 2010 and March 2015 in Alberta, Canada. Laboratory investigations for renal function, serum electrolytes (sodium and potassium), low‐density lipoprotein (LDL) cholesterol, and diabetes (fasting blood glucose and hemoglobin A1c), measured within 1 year of diagnosis, were examined, and the frequency of abnormalities determined. A total of 225 296 cases of incident hypertension were identified. Of these, 74.3% received at least one of the four guideline‐recommended laboratory tests, but only 42.3% received all four tests. Patients who received any testing, compared to subjects who did not, were on average older (median age 55.9 vs 51.2 years, P < .001) and had more comorbidity (14.5% vs 2.8% with a Charlson comorbidity index ≥ 3, P < .001). Laboratory abnormalities with the potential to affect clinical decision‐making were more common among multi‐comorbid patients. Patients with renal dysfunction (6.7% vs 11.6%, 26.3%, P < .001), electrolyte abnormalities (9.8% vs 12.6%, 20.5%, P < .001), and diabetes (13.4% vs 25.1% vs 38.8%, P < .001) were found in patients with Charlson scores of 0 vs 1‐2 vs ≥3, respectively. Our study found most patients diagnosed with hypertension received some laboratory testing, but rates of laboratory testing and frequency of abnormalities varied by clinical context. Testing and abnormalities detected were both more common among older patients and patients with comorbidities.