bluuebunny/crossref_metadata_2025 huggingface dataset:
APLIKASI PEMESANAN TIKET WISATA PANTAI MENGANTI BERBASIS MOBILE DENGAN INTERGRASI PEMBAYARAN DIGITAL
Authors: Setyawan Feri , Anggara Afwan
Published: November 2024

Pantai Menganti yang dikenal dengan pemandangannya,  merupakan salah satu destinasi wisata yang populer di kabupaten Kebumen. Saat ini, proses pemesanan dan pembayaran tiket wisata masih dilakukan secara manual, sehingga menyebabkan antrian panjang diloket dan menghambat efisiensi operasional. Oleh karena itu  aplikasi  pemesanan tiket wisata berbasis mobile dengan integrasi pembayaran digital diharapkan membantu pengelola dalam proses pemesanan dan pembayaran tiket agar lebih efiesien waktu sehingga tidak menimbulkan antrian panjang. jika tidak, antrian panjang di loket ini akan terus berlanjut yang mengakibatkan pengalaman wisata yang kurang menyenangkan dan menurunnya minat kunjungan wisatawan, yang akhirnya berdampak negatif pada pendapatan tempat wisata. Untuk mengatasi masalah ini, penelitian melakukan perancangan dan membuat aplikasi berbasis mobile yang mencakup fitur pemesanan tiket, pembayaran online, dan pengecekan tiket.  Dengan menggunakan metode Waterfall , diharapkan langkah-langkah yang diambil meliputi analisis masalah, pengumpulan data melalui survei dan wawancara, perancangan sistem, implementasi , pengujian, dan pemeliharaan aplikasi untuk memastikan semua fitur berfungsi dengan baik. Hasil sementara menunjukkan bahwa aplikasi ini dapat membantu pengelola  wisata dalam meningkatkan efisiensi waktu proses pemesanan dan pembayaran sehingga memberikan pengalaman yang lebih baik bagi pengunjung.
PERANCANGAN SISTEM MANAJEMEN WIFI BERBASIS WEB UNTUK PENGELOLAAN DATA PELANGGANDI MEGADATA NET
Authors: Marendra Alfin Nur , Hidayat Ahmad Tri
Published: November 2024

MEGADATA NET sebagai penyedia layanan internet lokal, memerlukan solusi manajemen data pelanggan yang lebih efektif guna meningkatkan efisiensi operasional dan kualitas layanan. Sistem pencatatan manual yang masih diterapkan saat ini seringkali menimbulkan kesalahan dan menunda proses pengelolaan data. Penelitian ini merancang sebuah sistem manajemen berbasis web yang dibangun menggunakan teknologi PHP, MySQL, dan framework Laravel. Sistem ini memfasilitasi pengelolaan data pelanggan, pemantauan pembayaran, serta penyusunan laporan secara real-time, sehingga dapat mengurangi ketergantungan pada pencatatan manual. Diharapkan, penerapan sistem ini tidak hanya meningkatkan efisiensi operasional dan akurasi data, tetapi juga memudahkan pelanggan dalam mengakses informasi terkait layanan serta status pembayaran mereka. Selain itu, sistem ini juga diharapkan dapat meningkatkan kepuasan pelanggan dan memperkuat keamanan data.
SISTEM REKAM MEDIS DAN PENDAFTARAN ONLINE BERBASIS WEB DAN ANDROID UNTUK MENINGKATKAN EFISIENSI KLINIK
Authors: Ghazalba Zaedar , Anggara Afwan
Published: November 2024

Perkembangan teknologi informasi telah mendorong digitalisasi layanan kesehatan, termasuk sistem pendaftaran dan rekam medis di klinik. Penelitian ini bertujuan untuk merancang dan mengimplementasikan sistem pendaftaran online dan rekam medis berbasis web dan mobile Android yang efisien. Sistem ini menggunakan teknologi REST API untuk menghubungkan aplikasi pendaftaran online dengan basis data klinik yang aman. Metode pengembangan yang digunakan melibatkan framework Laravel untuk back-end dan Kotlin untuk aplikasi mobile. Hasil dari penelitian ini menunjukkan bahwa sistem yang dikembangkan mampu mempermudah proses pendaftaran pasien, mengurangi waktu antrian, dan meningkatkan efisiensi pengelolaan rekam medis di klinik. Dengan demikian, sistem ini berpotensi meningkatkan kualitas layanan kesehatan di klinik-klinik yang menerapkannya.
The Minimal Cost Implication of Establishing a Pharmacy School in Nigeria
Authors: Ojo Ebunoluwa S. , Ayodapo Oluwadare J. , Wilson Oyekigho E.
Published: November 2024

Background: Nigeria is arguably known for its robust higher educational system. Despite the extensive educational system, the availability of recognized pharmacy schools remains limited. The slow expansion of pharmacy programs is attributed, in part, to funding challenges confronting tertiary institutions. This highlights stepwise approach of the study, which focuses on equipment and human resources as the initial critical cost factors necessary for establishing an accredited pharmacy school to meet the growing demand for qualiﬁed pharmacists in Nigeria. This study investigates the comprehensive cost analysis associated with establishing a new pharmacy school in Nigeria, focusing on procuring essential equipment and recruiting necessary human resources.
Methods: Utilizing regulatory requirements as a benchmark, the study employed online market stores to estimate equipment costs. Primary data was collected through an inquiry form to ascertain equipment prices, while secondary data from regulatory agencies and the salary and Wages Commission in Nigeria informed the cost requirements for both physical equipment and human resources (teaching and non-teaching).
Results: Findings reveal that the initial equipment investment required is approximately US$303,834. According to regulatory bodies, staﬃng must be according to student enrollment. Therefore, to launch the school with 25 students, a minimum of 4 lecturers, a technical and administrative personnel across ﬁve departments is required. The cost calculation is based on the basic salary structure for teaching and non-teaching staﬀ essential for the school's inception. The projected start-up costs human resources are estimated at  $91,485 per year.
Conclusion: The total expenditure (equipment and human resources) for establishing a pharmacy school is approximated at $395,319 emphasizing the ﬁnancial considerations crucial for instituting and sustaining a pharmacy education program in Nigeria.
Quality Assessment of Fifteen Brands of Paracetamol Injections Marketed in Lagos, Nigeria
Authors: Akinnurun Oluwafunmilayo D. , Ezeah Chinedu G. , Akinleye Moshood O.
Published: November 2024

Background: Paracetamol injection is a widely used medication for the management of pain and fever in healthcare settings. Ensuring the quality and safety of pharmaceutical products is essential to protect public health, so there is need to investigate the quality of these Pharmaceutical preparations in Lagos, Nigerian drug market in compliance with international standards and guidelines.
Method: Fifteen brands of paracetamol injections were sourced from registered pharmacies in Lagos. The sampled products were subjected to a comprehensive quality assessment using standard protocols, including testing for the presence of speciﬁed indicator pathogens using compendial procedures like sterility testing and assessment of active pharmaceutical ingredient (API) contentthrough high-performance liquid chromatography (HPLC).
Results: Results from the study indicated that 86.67 % of the paracetamol injection samples have the Active Pharmaceutical Ingredient (API) content within the acceptable limit of the United States Pharmacopoeia (USP) 2018, but 13.33 % of the paracetamol injection samples were found to be above the maximum acceptable limit. The sterility test results showed that none of the paracetamol injections samples recorded microbial load above the limit of USP.
Conclusion: The ﬁndings of this study highlight potential quality issues in the paracetamol injection products marketed in Lagos, Nigeria. Further investigations and continuous monitoring by regulatory authorities are recommended to ensure the consistent supply of safe and eﬀective paracetamol injection formulations to healthcare providers and patients in Lagos and beyond.
Identiﬁcation of Some Bioactive Compounds from Camellia sinensis as Possible Inhibitors of human epidermal growth factor receptor 2 (HER2): A Structure-Based Drug Design for Breast Cancer Treatment.
Authors: Ebenyi Lilian N. , Egwuom Chidinma B. Godswill , Halilu Emmanuel M. , Obialor Akachukwu P. , Johnson Titilayo O. , Adegboyega Abayomi E. , Chigozie Victor U. , Nwali Basil U.
Published: November 2024

Background: Overexpression of HER2 has been related to a variety of malignancies, including breast cancer, and its inhibition has been established as an eﬀective strategy for treating HER2-positive breast cancer. Because of its capacity to block carcinogenesis and reduce the proliferation of breast cancer cells, Camellia sinensis has been proven to be a source of anticancer agents.
Methods: In this study, the phytochemical library of Camellia sinensis was screened for inhibitory potentials against HER2 using molecular docking, pharmacophore modelling, ADMET studies, and molecular dynamic (MD) simulation.
Results: Gallocatechin, tricetinidin, SCHEMBL1950917, camellianin B, myricetin 3-glucoside, myricetin, camelliaside A, tricetin, faralateroside, and quercetin are the top-scoring compounds, with docking scores ranging from -9.327 kcal/mol to -8.147 kcal/mol. The selected compounds occupied the deﬁned binding site and interacted with the same amino acid residues as the reference compound(03Q). The identiﬁed phytochemicals produced hydrophobic contacts with target amino acid residues of the HER2 ATP binding region in addition to one or more hydrogen bond interactions. Gallocatechin, possess favorable ADME properties and appeared to be the safest of all the chemicals, with an LD50 of 10,000 mg/kg, toxicity class 6, and no inclination toward any of the toxicity checkpoints. In the MD simulation, the gallocatechin-HER2 complex showed good stability, with GLN 799 and THR 862 retaining hydrogen bonds for 99% and 97% of the simulation, respectively.
Conclusion: The HER2-inhibiting potentials and favorable ADMET properties demonstrated by these compounds, especially gallocatechin, make them suitable for further experimental studies and development into drugs against HER2-positive breast cancer.
A new bicyclic azepinoindole alkaloid from the seed cotyledon of Chrysophyllum albidum G. Don-Holl. (Sapotaceae)
Authors: Taiwo Bamigboye Josiah , Awotuya Iyanu Oluwafemi
Published: November 2024

Background: Previous investigation in our laboratory revealed the presence of beta carbolines in the seed cotyledon of Chrysophyllum albidum (G. Don), Sapotaceae. Recent developments underscore the utility of repurposing antifungal compounds for anticancer activities. As a continuation of our search for antcancer compounds from Nigerian medicinal plants, the seed cotyledons of Chrysophyllum albidum (G. Don), Sapotaceae was re-investigated for the expression of anti-tumour compounds.
Methods: The seed cotyledons of C albidum were air-dried under shade for two weeks after which they were powdered using Hammer mill. The powdered seed cotyledons was extracted with methanol (100 %). The methanol (MeOH) extract was defatted and subjected to solid phase extraction using Strata C-18-E cartridge (Phenomenex, USA) (20 g), to obtain four fractions (CA1-CA4). Further puriﬁcation of CA1 on silica gel (mesh 200-400) gave pure compounds 1 and 2. Both compounds were subjected to extensive spectroscopic analysis using NMR (1H- and 13C-NMR, 1H–1H COSY, DEPT, HMQC, HMBC) and ESI-MS spectra. Cell viability assay was carried out on the identiﬁed compounds using MTT assay.
Results: Compounds 1 and 2 were named (provisionally) as albidumine, a new azepinoindole alkaloid, and bamindolinol, a new fused beta carboline, respectively. The compounds did not show any signiﬁcant eﬀect against human cervical adenocarcinoma (HeLa) cell line in the cytotoxicity assay.
Conclusion: Two new beta carbolines were identiﬁed from the seed cotyledon of C albidum for the ﬁrst time.
Anxiolytic and antiamnesic potentials of Terminalia A. Chev (Combretaceae) stem and root bark methanol extracts in mice.
Authors: Akinpelu Lateef A. , Adebayo Muritala A. , Aiyelero Oyeronke M. , Eniaiyewu Oluwasegun I. , Bobra Raymond T. , Anyacho Somtochukwu O.
Published: November 2024

Background: Terminalia ivorensis (Chev) stem bark is used in combating mental illnesses in African traditional medicine. Previous studies demonstrated its antipsychotic properties but there are no documented reports on the anxiolytic and antiamnesic properties of Terminalia ivorensis. Hence, this study investigated the anxiolytic and antiamnesic potentials of methanol stem bark and root barkextracts of T. ivorensis in mice. Methods: The anxiolytic potentials of stem and root bark methanol extracts at 100, 200 and 400 mg/kg b.w were investigated using mouse model of anxiety (elevated plus maze test), while the antiamnesic potentials were assessed using mouse model of short term memory assessment (Y-maze test). Results: The stem and root bark methanol extracts at all the tested doses, signiﬁcantly (p≤0.05) elongated the percentage number of entries into the open arm of the elevated plus maze, while the duration of stay on the open arm of the elevated plus maze was only signiﬁcant (p≤0.05) at 100 mg/kg for stem bark extract. Stem and root bark extracts, at all the tested doses, signiﬁcantly (p≤0.05) reduced the anxiety indices of mice indicative of antianxiety potentials. Both extracts showed signiﬁcant (p≤0.05) dose-dependent decrease in percentage correct alternations compared to the scopolamine control group indicating antiamnesic eﬀect. Conclusion: This study revealed that stem and root bark extracts may possess anxiolytic and antiamnesic eﬀects in mice which justify its use in treating mental illnesses in traditional medicine.
Ameliorating Effects of Honey on Ethanol, Caffeine, Morphine and Scopolamine- Novelty Induced Behaviors and Memory Impairment in Male Albino Mice
Authors: Akanmu Ayodele Oluwasoji , Oluwole Olusayo , Akanmu Moses Olugbenga Atanda , Adeyemi Isaac Oluwole , Paul Leonard Mela , Balogun Sulayman Tunde , Sodipo Olufunke Adebola
Published: November 2024

Background: Honey is a natural substance produced by honey bees and was found to be useful to humankind since ancient times. It has medicinal properties and found to possess inhibitory eﬀects on the Central Nervous System (CNS).
Methods: Thus, we evaluated its ameliorating eﬀects of honey on scopolamine, morphine, caﬀeine and ethanol induced behavioral models: Novelty-Induced Behaviors (NIB), learning and memory impairment in male mice.
Results: The results indicated that honey showed a signiﬁcant eﬀect on morphine and scopolamine- induced locomotor activity {[morphine: [F (3,19) = 11.736; p = 0.0003) and scopolamine: [ F (3,19) = 29.673; p = 0.0001)]}. Honey signiﬁcantly reduced ethanol, morphine, scopolamine and increased the caﬀeine eﬀects on rearing behavior [ethanol: [F (3,19) = 13.724; p = 0.0001); morphine: [ F (3,19) = 18.167; p = 0.0001); scopolamine: [ F (3,19) = 5.523; p =0.008 and caﬀeine: [F (3,19) = 3.506; p = 0.039)] when compared with control groups. In grooming, honey signiﬁcantly reduced eﬀect of morphine and increased scopolamine-induced behavior [morphine: F (3,19) = 12.895; p = 0.0002) and scopolamine: [ F (3,19) = 9.465; p = 0.0008)]. Honey produced a signiﬁcant eﬀect on ethanol andmorphine with spatial working memory in mice [ethanol: [ F (3,19) = 5.236; p = 0.010) and morphine: [ F (3,19) = 10.080; p = 0.0006)]. In elevated plus maze test, honey signiﬁcantly increased the transfer latency of ethanol: [ F (3,19) = 0.08805; p = 9656); morphine: [F (3,19) = 1.610; p = 0.2265; scopolamine: [ F (3,19) = 0.1695; p = 0.9154) and (Caﬀeine: [ F (3,19) = 0.1736; p = 0.9127]) on spatial working memory impairment in mice.
Conclusion: In conclusion, honey has signiﬁcant inhibitory eﬀects on ethanol, morphine, scopolamine and caﬀeine pharmacological eﬀects on the CNS.
Prevalence, awareness, and patterns of non-steroidal anti-inﬂammatory/pain relief drug use among Undergraduates in Delta State, Nigeria: a cross-sectional study
Authors: Edjophe Arute John , Ikuesiri Agare Goodnews , Odion Prisca Omonigho , Clement Aghoja Ogheneovo
Published: November 2024

Background: This study aims to oﬀer insights into the knowledge, awareness and prevalence that exists among undergraduates in Delta State regarding the appropriate use of NSAIDs and other pain relievers.
Methods: This study was a simple, randomly selected cross-sectional descriptive study that utilize a pre-tested questionnaire from a similar study for data collection. The questionnaire was well structured and pretested, comprising 19 open and closed-ended questions, including sub-questions that covered topics from social demographics to knowledge and prevalence. For associations with demographic variables, data analysis employed frequency and percentage counts, as well as chi-square inferential statistics. A p-value of 0.05 was considered statistically signiﬁcant.
Results: The study found that 56.8% of participants were female, mostly aged 21-25. Painkiller use was prevalent at 83.3%, with common choices being Paracetamol, Ibuprofen, Aspirin, Diclofenac, and Indomethacin for various pains. Eﬀectiveness inﬂuenced drug selection for 26.5% of respondents, while healthcare professionals prescribed 33% of the drugs used. For pain management, 45.9% sought hospital advice, and 27% visited chemists. Additionally, 54% of respondents knew the correct dosage, but only 48.3% adhered to it. Over 20.3% rated their awareness of adverse drug reactions (ADRs) as good. Common side eﬀects included sweating, heartburn, chest pain, and stomach pain. The P-values for associations between sociodemographic variables and prevalence were 0.250 for gender and 0.0001 for both age and ethnicity respectively.
Conclusion: The study revealed that over half (54%) of respondents had good knowledge of NSAIDs and a high prevalence (83.3%) of NSAID use, with 30% of respondents stating their awareness of ADRs associated with undergraduate students in Delta State. The high prevalence of NSAIDs use underscores the need for continued public health education on the safe and eﬀective use of these medications.
In silico and in vivo anti-stress potential of Stachytarpheta cayennensis (Verbenaceae) in mice
Authors: Akanmu ItunuOluwa M. , Akinpelu Lateef A. , Aliyu A. , Akanmu Moses A.
Published: November 2024

Background: Stachytarpheta cayennensis is locally used as an antistress agent but no scientiﬁc rationale for its use. Hence, this study evaluated the antistress potential of ethanol leaf extract of Stachytarpheta cayennensis (ELSC) in mice.
Methods: The stress induced anxiety was assessed using elevated plus maze following acute restraint stress in mice. The in silico studies of previously reported compounds from Stachytarpheta cayennensis (S. cayennensis) were also carried out.
Results and discussion: There was signiﬁcant (p<0.001) increase in anxiety status of stressed control mice compared to the unstressed control suggesting stress induction. However, ELSC stressed at 125 and 250 mg/kg and diazepam stressed control signiﬁcantly (p<0.001) reduced the anxiety indices of mice compared to the stressed control group suggesting the reversal of stress-induced anxiety in mice. The results of in silico studies revealed betulinic acid was the most favourable compound in terms of pharmacokinetics, toxicity proﬁle and binding aﬃnity. The post docking analysis showed that betulinic acid and the positive antistress drug (diazepam) interacted with amino acid residues of the target receptor protein active pockets. Moreso, betulinic acid has a stronger binding aﬃnity (-7.8Kcal/Mol) compared to diazepam (-6.9 Kcal/Mol), suggesting that betulinic acid may be a more eﬀective antistress agent than diazepam.
Conclusion: This study therefore, concluded that betulinic acid may at least in part be responsible for the observed antistress eﬀect of Stachytarpheta cayennensis. However, further studies may be carried out on the antistress potential of betulinic acid.
Assessing Cataract Awareness and Public Health Implications in Amuwo-Odoﬁn and Alimosho Local Government Areas of Lagos State: A Cross- Sectional Study
Authors: Akhimen Izehi S. , Odegbo Samuel G. , Abiola Qudus A. , Hassan-Sodiq Ruqoyat , Shomuyiwa Deborah O. , Bakare Saidat M.
Published: November 2024

Background: Cataracts are the second leading cause of visual impairment and the ﬁrst of blindness  globally. Despite its high prevalence and impact, there is a dearth of studies on the awareness of cataracts and its public health impact in Nigeria. The study aimed to assess the awareness of cataracts and their public health implications in the Amuwo-odoﬁn and Alimosho Local government areas of Lagos State.
Methods: This was a cross-sectional study using a self-administered structured questionnaire to collate data from General Hospital and Ikotun Market in Alimosho Local Government Area as well as the Nigeria Navy Reference Hospital in Amuwo-Odoﬁn Local Government Area of Lagos state.
Results: The study had 162 participants, mostly between 40 and 49 (49.4%). The majority of the participants were females (53.3%). Nearly half (48.8%), of the study participants have tertiary education. In this study, 64.7% of participants have heard about cataracts at some point and 52.2% are aware that cataracts involve the cloudy vision of the eyes.
Conclusion: Cataract remains the primary cause of treatable blindness highlighting the need for awareness through public health campaigns. While the majority of the participants have good knowledge about cataracts, a knowledge gap regarding cataract risk factors and prevention was identiﬁed. Therefore, public health campaigns are necessary to address these knowledge gaps.
O DESENVOLVIMENTO DO CONHECIMENTO NA OBRA A TOMADA DE CONSCIÊNCIA
Authors: Terribile Mayara de Andrade
Published: November 2024

This article aims to bring to light the Piagetian explanations about the development of knowledge in the workThe Awareness Takeover. In the second part, we will briefly present the discussion on the relationship betweentechnique and science that is proposed by Jean Piaget in the introduction to the book To do and to understand.
SANATTA DİSİPLİNLERARASI ETKİLEŞİMLER: ARNOLD SCHOENBERG VE WASSILY KANDINSKY
Authors: Pekdemir Peker Ruba
Published: November 2024

ÖZ
20. yüzyılın başları, sanatta köklü değişimlerin yaşandığı bir dönemdir. Bu dönemde, geleneksel formların ve tekniklerin ötesine geçme arayışı hem ressamlar hem de besteciler arasında benzer yenilikçi eğilimlere yol açmıştır. Wassily Kandinsky ve Arnold Schoenberg’in sanat dünyasındaki rolleri, modern sanatın şekillenmesinde kritik bir öneme sahiptir. Kandinsky ve Schoenberg, hem resim hem de müzik alanında normatif sınırları zorlayarak, içsel deneyimlerin ve ruhsal durumların derinliklerine inen eserler üretmişlerdir. Schoenberg’in atonal müziği, melodik yapıları geleneksel sınırların ötesine taşıyarak, dinleyicilere alışılmışın dışında bir müzikal deneyim sunmuş; bu müzik anlayışı, duygusal ifadede radikal bir değişim yaratmıştır. Kandinsky’nin soyut sanat anlayışı, renklerin ve formların, ruhsal durumları yansıtmak için kullanıldığı bir dil geliştirmiştir. Her iki sanatçının eserleri, birbirlerinden bağımsız görünse de, etkileşimleri ve ortak vizyonları, modern sanatın evriminde önemli bir dönüm noktası oluşturmuştur. Kandinsky’nin soyutlamaları ve Schoenberg’in müziği, sanatın soyut ve duygusal yönlerini keşfetme çabalarıyla iç içe geçmiş, böylece resim ve müzik arasındaki sınırların belirsizleşmesine yol açarak yeni ifade olanakları sunmuştur. Disiplinlerarası sanat anlayışı, Kandinsky ve Schoenberg gibi sanatçıların eserlerine somut bir şekilde yansımıştır.
A IMPORTÂNCIA DA EQUIPE DE ENFERMAGEM NA PREVENÇÃO DA VIOLÊNCIA OBSTÉTRICA
Authors: Silva Carla Kailany Alves da , Silva Eva Rodrigues da , Santos Joseane Almeida dos , Duarte Joyce , Sá Maria do Carmo Carvalho de Souza , Santana Sunamita da Silva
Published: November 2024

A violência obstétrica (VO) configura-se como uma grave violação dos direitos das mulheres, comprometendo a humanização do parto e a autonomia feminina. Este estudo teve como objetivo analisar a importância dos profissionais de enfermagem na prevenção da VO, dado seu papel essencial no acompanhamento humanizado durante o parto e pós-parto. Trata-se de uma Revisão Integrativa, foram incluídos estudos em português, de acesso gratuito, publicados entre 2019 e 2024, e disponíveis na base de dados Google Acadêmico. Usando o protocolo PRISMA, a revisão identificou 892 estudos, dos quais 10 atenderam aos critérios de inclusão e foram analisados em profundidade. Os resultados destacam que os enfermeiros têm um papel crucial na criação de vínculos de confiança e no oferecimento de um atendimento digno, seguro e empático. Esse atendimento humanizado pode prevenir a VO e promover o respeito aos direitos reprodutivos. Conclui-se que a capacitação contínua dos enfermeiros e a implementação de políticas públicas de saúde são essenciais para garantir um parto humanizado. O estudo reforça a necessidade de investir em formação técnica e ética dos profissionais, para que possam atuar de forma transformadora e assegurar uma experiência positiva e respeitosa para as parturientes.
RELAÇÃO ENTRE TRAUMA NA INFÂNCIA E O DESENVOLVIMENTO DO TRANSTORNO DE PERSONALIDADE BODERLINE: PERSPECTIVAS MORFOFISIOLÓGICAS E EPIGENÉTICAS
Authors: Vargas Eduarda Liduario de Barros , Ribeiro Victor Furtado , Lara Ana Catarina de Almeida Pinho , Pereira Larissa Mirelle de Oliveira
Published: November 2024

O Transtorno de Personalidade Borderline (TPB) é caracterizado por labilidade emocional, distorções na autoimagem e um senso persistente de vazio. A dificuldade em regular respostas emocionais intensas, agravada pelo medo do abandono, contribui para conflitos interpessoais e déficits em várias esferas da vida. O trauma durante a infância é identificado como o principal elemento ambiental associado ao TPB. Estudos revelam que, entre os indivíduos diagnosticados com esse transtorno, de 30% a 90% experienciaram algum tipo de abuso ou negligência durante sua fase infantil. A relação entre trauma infantil e TPB é complexa, com traumas funcionando como gatilhos para características do transtorno. Neste contexto, o presente trabalho teve como objetivo explorar as implicações clínicas, neurológicas e epigenéticas dessa relação, destacando sua etiologia multifacetada, abrangendo mecanismos morfofisiológicos e epigenéticos associados ao trauma infantil como fator de risco para o TPB, contribuindo para uma compreensão mais profunda e informada dessa condição complexa. Desse modo, realizou-se uma revisão sistemática da literatura levado em conta os últimos 26 anos. A pesquisa ocorreu nas nas bases de dados da SCIELO, Google Acadêmico, PubMED e Science.gov, resultando em 839 artigos, dos quais 55, selecionados por critérios de inclusão, serviram de base para este estudo. Ao finalizar a revisão, constatou-se uma correlação significativa entre traumas na infância e o desenvolvimento do TPB. A interconexão entre fatores biológicos, genéticos e ambientais destaca a necessidade contínua de investigação e compreensão aprofundada desses elementos para informar abordagens terapêuticas e intervenções eficazes no contexto do TPB.
GESTÃO DA DIVERSIDADE E INCLUSÃO NAS ORGANIZAÇÕES: ESTUDO DE CASO SOBRE A EMPRESA GOOGLE
Authors: Santos Silas Silva , Santana Expedito dos Santos , Lins Ittana de Oliveira , Santos Cristiane Nunes dos
Published: November 2024

Este artigo investiga as práticas de Gestão da Diversidade e Inclusão (D&I) nas organizações, com foco no estudo de caso da Google, uma empresa reconhecida por suas iniciativas pioneiras no setor da tecnologia. Utilizando uma abordagem qualitativa, a pesquisa baseia-se em análise documental profunda e contextualizada das percepções e experiências relacionadas às práticas de diversidade e inclusão no ambiente corporativo, considerando a diversidade em suas múltiplas dimensões: gênero, raça, orientação sexual, idade, habilidades e experiências. O estudo revela que a gestão de diversidade e inclusão é fundamental para promover inovação e melhorar o desempenho organizacional, além de fortalecer o compromisso com a justiça social. As iniciativas da Google, como o uso de inteligência artificial para mitigar preconceitos inconscientes, programas de treinamento e redes de afinidade, demonstram como a diversidade e inclusão pode ser integrada à cultura organizacional, embora ainda exista desafios a serem superados, como a sub-representação de minorias em cargos de liderança. Os resultados oferecem insights e recomendações para empresas que buscam implementar ou aprimorar políticas inclusivas, destacando a diversidade e inclusão como um processo contínuo que demanda compromisso, inovação e e adaptação estratégica às particularidades de cada organização.
ATUAÇÃO DO ENFERMEIRO NA QUALIDADE DE VIDA DA CRIANÇA COM DOENÇA CRÔNICA
Authors: Ruas Mariane Dias , Araújo Ana Kelly dos Santos Freitas , Pinto Emanuel Vieira
Published: November 2024

O enfermeiro enfrenta desafios na assistência ao desenvolvimento biopsicossocial da criança com doença crônica, que tem sido obstáculo da qualidade de vida e compromete o estado físico, social e psicológico, considerado uma das principais causas de morbidade e mortalidade infantil. Diante disso, o presente artigo estabelece a seguinte problemática: qual assistência de enfermagem está sendo prestada à criança com doença crônica? O objetivo geral visa analisar o papel do enfermeiro no desenvolvimento biopsicossocial de crianças com doença crônica. Desse modo, os objetivos específicos pautam-se em observar os possíveis danos que podem ser gerados a partir da doença; melhorar a qualidade de vida; contribuir para a aprendizagem cotidiana dos profissionais de saúde; e elaborar promoção, proteção e prevenção de doenças crônicas e associadas. Metodologicamente contém estudo de abordagem qualitativa, desenvolvido por meio de pesquisas bibliográficas e documentais, com revisão integrativa da literatura nas bases de dados BDTD, BVS e SciELO. Os resultados evidenciaram dificuldade da equipe de enfermagem quanto à orientação necessária que deve ser passada aos familiares/cuidadores; no esclarecimento quanto à doença; na humanização do atendimento; e na necessidade de materiais necessários, percebendo assim necessidade de melhoria na estrutura das redes de atenção e também no investimento em educação permanente.
A EVOLUÇÃO DO SISTEMA DE PROPULSÃO EM EMBARCAÇÕES OFFSHORE
Authors: Lemos Leandro Rosa de , Silveira João Paulo Bittencourt da
Published: November 2024

O presente estudo mostra a evolução da propulsão naval, desde a utilização de velas em embarcações, até o surgimento dos motores a diesel. No século XX a propulsão mecânica dominou o cenário, posteriormente, o avanço na área de eletrônica de potência, contribuiu com o controle de motores elétricos. Nos dias de hoje, com os avanços tecnológicos, desencadeou a existência de vários tipos de sistemas de propulsão. O uso da propulsão elétrica, foco deste estudo, trouxe muitas vantagens como redução no consumo de combustível, redução nos impactos ambientais, simplificação de projeto, construção, dentre outras. Por se tratar de sistemas de potência confiáveis, os navios que utilizam essa tecnologia são capazes de atenderem demandas de energia crescentes, principalmente as embarcações de apoio offshore.
A ERA DA EXPOSIÇÃO: O IMPACTO DAS MÍDIAS SOCIAIS NOS DIREITOS DA PERSONALIDADE
Authors: Soares Elias Emanuel da Silva , Azevedo Flávia Regina Porto de
Published: November 2024

A vida no ambiente digital, principalmente relacionada às mídias sociais, tem proporcionado constantemente aos direitos da personalidade uma maior exposição à riscos e abusos por outros usuários. Essas plataformas proporcionam novas formas de interação, acesso à informação e manifestação do pensamento, mas também facilitam a disseminação de dados pessoais, discursos de ódio, injúrias, compartilhamentos indevidos de conteúdos, que corroboram para violações desses direitos. A presente pesquisa explora a proteção dos direitos da personalidade, sobretudo à imagem, honra e intimidade das pessoas no ambiente digital, com ênfase nos desafios jurídicos relacionados ao uso das mídias sociais. O estudo justifica-se pela relevância social e jurídica do tema, haja vista o número crescente de incidentes relacionados a crimes de ódio e violações dos direitos personalíssimos nesse ambiente, ressaltando a importância de se encontrar um equilíbrio entre a liberdade de expressão e os demais direitos da personalidade protegidos. Além disso, o estudo busca demonstrar às pessoas acerca de suas responsabilidades civis e criminais ao compartilharem conteúdos ofensivos não só nas mídias sociais, mas também na internet como um todo. A metodologia adotada envolve uma abordagem qualitativa, com base em pesquisa bibliográfica, utilizando livros, artigos científicos, Constituição Federal e outras legislações nacionais relacionadas ao tema.
TRATAMENTO DE FLACIDEZ FACIAL COM RADIOFREQUÊNCIA
Authors: Alarcão Arielly Caroline Silva
Published: November 2024

A flacidez facial é uma condição caracterizada pela perda de tônus e elasticidade da pele, resultante de fatores como envelhecimento, exposição solar, perda de peso e predisposição genética. Com o avanço da tecnologia estética, a radiofrequência surge como uma alternativa eficaz para tratar essa condição, promovendo a recuperação da firmeza cutânea. Este artigo revisa os métodos de radiofrequência utilizados para o tratamento da flacidez facial e avalia sua eficácia em estimular a produção de colágeno e elastina. Os métodos incluem técnicas monopolares, bipolares e multipolares, que variam em profundidade de penetração e intensidade. A eficácia da radiofrequência é evidenciada em diversos estudos clínicos, que demonstram melhorias significativas na textura e elasticidade da pele após as sessões de tratamento. Os principais achados incluem o aumento da produção de colágeno, a melhora na hidratação da pele e a redução da flacidez, resultando em um rejuvenescimento facial visível. Além disso, os efeitos colaterais são geralmente mínimos e temporários, reforçando a segurança do procedimento. Em conclusão, a radiofrequência apresenta-se como uma opção viável e eficaz para o tratamento da flacidez facial, oferecendo resultados satisfatórios e duradouros, sendo uma escolha interessante para pacientes que buscam intervenções estéticas não invasivas.
EFICÁCIA DA TOMOGRAFIA POR EMISSÃO DE PÓSITRONS (PET) COMBINADA COM TOMOGRAFIA COMPUTADORIZADA (CT) NA DETECÇÃO PRECOCE DO CÂNCER
Authors: Bastos Thaillon Santos , Brito Neto Rogério da Costa , Pinto Emanuel Vieira
Published: November 2024

O presente estudo abordou o tema, eficácia da a Tomografia por Emissão de Pósitrons combinada com a Tomografia Computadorizada. Neste contexto, ressalta-se que, estes dois combinados são capazes de captar as imagens do corpo inteiro em 30 minutos, o que facilita detectar precocemente e localizar com precisão, de modo não invasivo, tumores malignos de pequenas dimensões e suas metástases. Diante da problemática indaga-se: qual a eficácia da Tomografia por Emissão de Pósitrons (PET), combinada com a Tomografia Computadorizada (CT), na detecção precoce do câncer? Na pesquisa, o objetivo geral tratou-se de uma análise sobre a eficácia que o PET -CT para detecção de câncer, pautados na investigação de como a Tomografia por Emissão de Pósitrons combinada com a Tomografia Computadorizada podem ser eficazes na detecção precoce do câncer. Enquanto que, os objetivos específicos pautados foram: Contextualizar o uso da tomografia por emissão de pósitrons (PET-CT) na prática clínica atual, destacando sua evolução e importância no diagnóstico do câncer; avaliar a precisão diagnóstica da tomografia por emissão de pósitrons (PET-CT) em detectar lesões cancerígenas; investigar a eficácia do PET-CT na monitorização da resposta ao tratamento oncológico; analisar o impacto da utilização do PET-CT na tomada de decisões clínicas e no desfecho dos pacientes. A Tomografia por Emissão de Pósitrons combinada com a Tomografia Computadorizada são capazes de captar as imagens do corpo inteiro em 30 minutos, o que facilita detectar precocemente e localizar com precisão, de modo não invasivo, tumores malignos de pequenas dimensões e suas metástases. O estudo realizado foi Revisão de Literatura através da abordagem qualitativa de método investigativo que permite a avaliação de vários autores no contexto. Após análise da pesquisa, os resultados apresentados demostram que o PET-CT parece ser o exame mais preciso entre as técnicas atuais para detectar o câncer.
LITERATURA E INCLUSÃO: PRÁTICAS PEDAGÓGICAS PARA A DIVERSIDADE
Authors: Almeida Armstrong Pereira de , Moura Cleberson Cordeiro de , Gondim Cristiane da Silva Reis , Lira Eder , Melo Nadilene Nery de , Vieira Núbia Nara Rocha , Cherubini Paulo Vinícius Ferreira
Published: November 2024

Este estudo investigou como a literatura infantil e a diversidade cultural contribuíram para o processo de inclusão escolar, buscando entender a relação entre esses elementos e a promoção de atitudes inclusivas. O objetivo geral foi analisar de que forma a literatura infantil e a formação docente voltada para a diversidade poderiam promover um ambiente escolar inclusivo. A pesquisa utilizou metodologia de revisão bibliográfica, com análise de obras relacionadas à inclusão, literatura infantil e práticas pedagógicas culturais. Os resultados indicaram que a literatura infantil desempenhou um papel significativo no desenvolvimento de atitudes de respeito e empatia entre os alunos, ao apresentar personagens e contextos diversos. Adicionalmente, constatou-se que a formação docente para a diversidade foi essencial para que os professores pudessem implementar práticas inclusivas de forma efetiva, apesar das barreiras estruturais e institucionais identificadas. Nas considerações finais, o estudo ressaltou a relevância de integrar a literatura infantil e uma formação docente direcionada para a diversidade, apontando a necessidade de políticas educacionais que incentivem essas práticas. Concluiu-se que a combinação desses fatores contribui para a construção de um ambiente escolar  inclusivo e acolhedor, embora estudos futuros sejam recomendados para ampliar a investigação sobre estratégias de ensino que favoreçam a inclusão.
Teacher Confidence in Meeting Students’ Needs in French as a Second Language Classes
Authors: Grant Robert , Mady Callie
Published: November 2024

In past practice in Ontario, Canada, students with learning difficulties have been afforded sporadic access to French as a second language (FSL) learning opportunities, contributing to limited exposure and preparation of teachers to meet the needs of these students. A change in policies now requires the inclusion of all students. In order to support students with learning difficulties in meeting with success, FSL teachers have repeatedly made it clear that they would appreciate professional development opportunities. This study used a collaborative-inquiry process to offer FSL teachers four professional development sessions on the topic of meeting the varied needs of students. Pre and post questionnaires and post interviews showed that the teachers gained confidence in their use of strategies to support students’ French comprehension and production. Participating FSL teachers highlighted the importance of not only the knowledge gained but also the opportunity for collaboration. In addition to gaining knowledge of and confidence in meeting the needs of students with learning difficulties, the FSL teachers were assured enough to question decisions on excluding such learners from second-language learning opportunities.
Determination of the optimal storage zone of functional beverages based on sprouted grain extracts using mathematical models
Authors: Moldakarimov Almaz , Iztayev Auyelbek , Muslimov Nurzhan , Yakiyayeva Madina , Muldabekova Bayan , Tursunbayeva Sholpan , Dikhanbayeva Fatima , Shintassova Saida , Dyusembaeva Zhanerke
Published: November 2024

Beverages based on sprouted cereals are an excellent basis for creating new types of functional foods, as they are rich in nutrients. Beverages made from sprouted grains aim to improve daily nutrition, prioritising food safety. The proper storage of these drinks depends on the processing techniques used, including chemical preservatives and the conditions under which they are stored. Thus, using a mathematical model, this study aimed to determine the optimal storage zone of functional beverages from sprouted raw materials with preservatives. The results of our study showed that the optimum storage temperature and citric acid content of wheat extract were 2.9% and +11°C; barley 2.4% and 18°C; triticale 2.2% and +11°C; sunflower 2.8% and +14°C; rapeseed 2.7% and +16°C; safflower 2.3% and +17°C; flax 2.6% and +17°C; soya 2.4% and +18°C; pea 2.3% and +18°C; chickpea 2.3% and +18°C, respectively. Overall, these outcomes theoretically support the processing of beverages from sprouted grains. Thus, for practical application, it is recommended to implement controlled storage environments with the recommended temperatures and ensure that citric acid is correctly dosed at the identified optimal levels to enhance the shelf life of beverages.
Osteosarcoma Tumor Detection using Different Transfer Learning Models
Authors:   American International University Bangladesh, Department of Computer Science, Dhaka, 1229, Bangladesh, Meem Raisa Fairooz , Hasan Khandaker Tabin ,   American International University Bangladesh, Department of Computer Science, Dhaka, 1229, Bangladesh
Published: November 2024

The clinical image analysis field has increasingly embraced
the utilization of transfer learning models due to their
reduced computational complexity and improved accuracy,
among other benefits. These models, which are pre-trained
and do not require training from scratch, eliminate the
need for extensive datasets. While transfer learning models
are primarily employed for brain, breast, or lung image
analysis, other areas such as bone marrow cell detection
or bone cancer detection can also derive advantages from
their use, particularly considering the limited availability of
large datasets for these specific tasks.
Analysis of Comorbid Conditions and Drug Utilization Patterns in Neuropathic Pain in India (The NEUTRON study).
Authors:   Head of Medical Affairs Department, Alkem Laboratories Ltd, Mumbai 400013., Mayabhate Mayur
Published: November 2024

Background and Objective: Neuropathic pain caused by a
lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality
of life. Objective of the present analysis is to investigate the
comorbidities and pharmacological management practices
employed in patients with neuropathic pain in India.
Methods: A retrospective, multi-centric, cross-sectional,
observational study enrolled 9,481 patients. Using medical
records of the patients, clinical parameters such as diagnosis,
symptom type and severity, patient demographics, and
comorbid conditions were collected. Chi-square tests, and
independent and paired samples t-tests were used for
statistical analysis.
Results: A significant proportion (41%) of the patients had
diabetic peripheral neuropathy. The burning sensation was
the most commonly reported symptom (68.5%), followed
by shooting pain (45.7%) and paraesthesia (26.6%). Anxiety
(28.3%) and depression (27.8%) were the most common
psychological comorbidities. Combination therapy of drugs
was prescribed in 61.8% of patients, while 38.5% received
monotherapy. Reduction in pain score from 7.15 to 4.16 (55%)
was observed post-treatment. Patients without comorbid
conditions experienced a greater pain reduction compared
to those with comorbidities (66% vs 53.5%, p = 0.001).
Conclusion: The study identified diabetic peripheral
neuropathy as the leading cause of neuropathic pain in
India, with a high prevalence of psychological disorders
among affected patients. While existing pharmacological
management approaches have demonstrated effectiveness by
significantly reducing pain scores, there is a need for improved
pharmacological and non-pharmacological therapies, or a
combination of both, to enhance outcomes further.
Comparative Analysis of Cardiovascular disease risk prediction Models: A Population-based Assessment of the Efficacy of ACC/AHA, Framingham, and QRISK.
Authors: Mahdavizadeh Vahid , Mansouri Mostafa ,   Clinical Research Development Unit, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Asadi Moloud , Shahri Bahram , Mouhebati Mohsen ,   Department of Cardiovascular, Mashhad University of Medical Sciences, Mashhad, Iran., Darroudi Susan , Mouhebati Mohsen ,   Vascular and Endovascular Surgery Research Center, Mashhad University of medical sciences, Mashhad, Iran., Talkhi Nasrin ,   Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Esmaily Habibillah ,   Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.,   Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Mobarhan Majid Ghayour ,   International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Published: November 2024

Objectives: Different models have been developed for the
assessment of cardiovascular risks, most of which are based
in the western countries. To ensure the applicability of these
models in non-Western nations, these models should be
studied in such populations. The present study aimed to
determine their applicability in a population-based study in
Iran.
Effect of Alcohol and Wnt Signaling Pathway Interactions in Zebrafish (Danio rerio) Tooth Development.
Authors: Zavareh Parnia Azimian , Chen Sophie , Raine Barbara Triggs , Atukorallaya Devi
Published: November 2024

Alcohol consumption during pregnancy can negatively affect
fetal development. Prenatal alcohol exposure (PAE) has
been associated with various birth defects and has shared
numerous dental deficits with individuals with Fetal Alcohol
Spectrum Disorder (FASD), such as Decayed, Missing, and
Filled Teeth (DMFT), malocclusion, caries, speech impairment,
and enamel defects. While distinct developmental defects
have been established, less is known about the mechanisms
leading to such phenotypes in tooth development.
Economic Teaching of Chiang Kai-shek: Political Assessments and Academic Interpretations (Part 2. A Critical Look through the Prism of Soviet Political Economy)
Authors: Borokh Olga
Published: November 2024

The paper examines the problems of perception of the content of Chiang Kai-shek’s book «Chinese Economic Teaching» (1943), shaped by political approaches and academic context. Soviet scholars of China’s modern history viewed Chiang Kai-shek’s book through the prism of Soviet political economy. The terminological substitutions made («goods» instead of «things», «money» instead of «wealth», «needs» instead of «wants») were largely due to the influence of the English edition, which offered interpretations of traditional Chinese concepts in terms of Western economics. The attempt to dock with the conceptual apparatus of Soviet political economy demonstrated the complexity of the transition between different systems of academic discourse and became an example of the emergence of misunderstanding due to the belonging of researchers to different scientific paradigms. Chiang Kai-shek’s political views remain alien to contemporary China. However, official calls for the synthesis of Marxism with the best traditions of Chinese culture created positive preconditions for an interested rethinking of his judgments on the specific features of Chinese economic thought.