bluuebunny/crossref_metadata_2025 huggingface dataset:
Dark-Side Personality Trait Interactions: Amplifying Negative Predictions of Leadership Performance
Authors: Simonet Daniel V. , Tett Robert P. , Foster Jeff , Angelback Anastasia I. , Bartlett Jennifer M.
Published: September 2017

Drawing on trait interaction theory and personality disorder subtypes, we examined narcissism-by-trait interactions (e.g., narcissism × antisocial tendencies) for predicting leadership performance in four independent archival samples ( Ns = 285, 120, 106, 559). This study extends research on multiplicative effects of normative leader characteristics to consider how narcissism becomes particularly disruptive when combined with other extreme interpersonal tendencies. Moderated multiple regression results show interactions involving selected trait pairs varied across samples. Pooled analyses showed (a) differential generalizability across trait pairings and (b) that lower tiered managerial roles and weaker industrial contexts may release such effects. Inconsistencies suggest the need to consider sample-specific trait demands in future trait interaction research, normal, or maladaptive. All told, findings suggest that subclinical personality interactions might accelerate leader derailment, offer unique insights into leader competence, and extend trait interaction research to aberrant tendencies.
Resistance to and Transformations of Gender-Based Violence in Spanish Universities: A Communicative Evaluation of Social Impact
Authors: Puigvert Lídia , Valls Rosa , Garcia Yeste Carme , Aguilar Consol , Merrill Barbara
Published: September 2017

Researchers in many fields, especially those engaged in the study of gender-based violence, have shown an interest in using mixed designs as innovative methodological procedures to transform social realities. In this article, we introduce the “communicative evaluation of social impact” as a methodological tool to reveal the social impact achieved by a multiphase mixed methods design conducted sequentially on gender-based violence in Spanish universities. This tool shows the transformative power of mixed methods with a communicative orientation to generate new legislation, create proper conditions for reporting abuse, and establish new solidarity dynamics with and among the victims to promote violence-free universities.
Ultrahigh Frequency Ultrasound Imaging of the Hand: A New Diagnostic Tool for Hand Surgery
Authors: Viviano Stephen L. , Chandler Laurel K. , Keith Jonathan D.
Published: September 2017

Background: Ultrasonography is a cost-effective, noninvasive, and expedient imaging modality with numerous clinical applications. Conventional ultrasound uses transducers with frequencies that range from 5 to 12 MHz. However, ultrahigh frequency ultrasound (UHFUS) is capable of producing frequencies up to 70 MHz, which can achieve tissue resolution up to 30 μm. The purpose of our study is to present the capabilities of a novel technology and to describe its possible clinical applications for hand surgery. Methods: The Vevo 2100 (VisualSonics, Toronto, Canada) system was used to perform all ultrasound exams. Four unique linear array transducers were employed. All studies were performed by the authors, who have no formal training in ultrasound techniques, on 5 healthy resident volunteers and 1 clinical patient under institutional review board approval. Results: A series of 10 static images per participant and dynamic, real-time videos were obtained at various locations within the hand and wrist. UHFUS is capable of quickly and reliably imaging larger structures such as foreign bodies, soft tissue masses, and the flexor tendons, and diagnosing an array of pathologies within these structures. In addition, UHFUS can identify much finer structures such as the intimal layer of the arteries in the hand and individual fascicles within the digital nerves to provide data about vessel quality and vascular and neural pathologies. Conclusions: UHFUS is a novel technology that shows multiple advantages over conventional ultrasound for imaging the fine superficial structures of the hand and wrist, and can be deployed by the surgeon at the point of care.
Verapamil-induced breakdown of the blood–brain barrier presenting as a transient right middle cerebral artery syndrome
Authors: Pace Jonathan , Nelson Jeffrey , Ray Abhishek , Hu Yin
Published: September 2017

A middle-aged patient presented for elective embolization of an incidentally found right internal carotid aneurysm. An angiogram was performed, during which the left internal carotid artery was visualized to evaluate a second, small aneurysm. During the embolization of the right internal carotid artery aneurysm, a catheter-induced vasospasm was identified that prompted treatment with intra-arterial verapamil. The procedure was uncomplicated; a postoperative rotational flat-panel computed tomography scan was performed on the angiography table that demonstrated right hemisphere contrast staining. The patient developed a right middle cerebral artery (MCA) syndrome after extubation with repeat cerebral angiography negative for occlusion and magnetic resonance imaging negative for stroke. The patient was observed for 48 hours, during which time the patient had slowly improved. At a six-week follow up visit, the patient had fully recovered. We present an interesting case of a verapamil-induced breakdown of the blood–brain barrier and self-limited right MCA syndrome.
Safety and effectiveness of the Phoenix Atherectomy System in lower extremity arteries: Early and midterm outcomes from the prospective multicenter EASE study
Authors: Davis Thomas , Ramaiah Venkatesh , Niazi Khusrow , Martin Gissler Hans , Crabtree Tami
Published: September 2017

Objectives

To evaluate the novel Phoenix Atherectomy System as percutaneous treatment of de novo and restenotic infrainguinal arterial lesions.

Methods

This prospective, multicenter, nonrandomized investigational device exemption trial was conducted across 16 US and German centers between August 2010 and April 2013. Intention-to-treat enrollment was 128 patients (mean age: 71.8 years, 59% male) with 149 lesions (mean length: 34 mm, mean diameter stenosis: 89.5%), and the primary analysis per-protocol population consisted of 105 patients with 123 lesions. The primary efficacy endpoint, technical success, was the achievement of acute debulking with a post-atherectomy residual diameter stenosis ≤50% (before adjunctive therapy). The primary safety endpoint was the major adverse event (MAE) rate through 30 days.

Results

For the primary analysis per-protocol population, the rate of lesion technical success was 95.1% (117/123), with the lower limit of the 95% CI 90.6%, meeting the prospectively established target performance goal of ≥86%. After post-atherectomy adjunctive therapy, residual stenosis was ≤30% for 99.2% (122/123) of lesions (mean final diameter stenosis 10.5%). Improvement of ≥1 Rutherford class occurred for 74.5% of patients through 30 days and for 80% through six months. MAEs were experienced by 5.7% (6/105) of patients through 30 days (with the upper limit of the 95% CI 11.0%, meeting the target performance goal of <20%), and 16.8% through six months. Six-month freedom from TLR and TVR was 88.0% and 86.1%, respectively.

Conclusions

Based on the high rate of technical success and the low rates of MAEs through six months, the Phoenix Atherectomy System is safe and effective for the debulking of lower-extremity arterial lesions. ClinicalTrials.gov identifier NCT01541774
Decolonizing both researcher and research and its effectiveness in Indigenous research
Authors: Datta Ranjan
Published: September 2017

How does one decolonize and reclaim the meanings of research and researcher, particularly in the context of Western research? Indigenous communities have long experienced oppression by Western researchers. Is it possible to build a collaborative research knowledge that is culturally appropriate, respectful, honoring, and careful of the Indigenous community? What are the challenges in Western research, researchers, and Western university methodology research training? How have ‘studies’ – critical anti-racist theory and practice, cross-cultural research methodology, critical perspectives on environmental justice, and land-based education – been incorporated into the university to disallow dissent? What can be done against this disallowance? According to Eve Tuck and K Wayne Yang’s (2012) suggestion, this article did not use the concept of decolonization as a substitute for ‘human rights’ or ‘social justice’, but as a demand of an Indigenous framework and a centering of Indigenous land, Indigenous sovereignty and Indigenous ways of thinking. This article discusses why both research and researcher increasingly require decolonization so that research can create a positive impact on the participants’ community, and conduct research ethically. This article is my personal decolonization and reclaiming story from 15 years of teaching, research and service activities with various Indigenous communities in various parts of the world. It presents a number of case studies of an intervention research project to exemplify the challenges in Western research training, and how decolonizing research training attempts to not only reclaim participants’ rights in the research but also to empower the researcher. I conclude by arguing that decolonizing research training creates more empathetic educators and researchers, transforming us for participants, and demonstrating how we can take responsibility for our research.
Bridging the logistical gap between ultrasound enthusiasm and accreditation
Authors: Reid George , Bedford Jonathan , Attwood Ben
Published: September 2017

Point-of-care ultrasound is increasingly recognised as a valuable adjunct to patient care. Trainees in intensive care medicine are expected to accredit in focused intensive care echocardiography, but the availability of trained mentors and logistical/geographical factors make this difficult within the time constraints required. As a result, many trainees who are enthusiastic about point-of-care ultrasound find it difficult to achieve accreditation. We present a secure, web-based, multi-user system which mitigates many of these difficulties and allows for clinical mentorship to take place without geographical barriers, and at a time convenient for the participants.
What do we really want from clinical documentation improvement programs?
Authors: Shepheard Jennie
Published: September 2017

Clinical documentation improvement (CDI) roles are being increasingly created in Australian hospitals. It is important to understand what good clinical documentation is and who is responsible for it as well as what these roles potentially offer our health system. This article explores the role of a CDI specialist, the benefits and pitfalls of clinical documentation improvement programs, and mounts an argument that health information managers and clinical coders are uniquely placed to fill these roles in Australian hospitals.
Porous Chambers, Echoes of Valence and Stereotypes
Authors: Turetsky Kate M. , Riddle Travis A.
Published: September 2017

Selective exposure to one-sided news coverage, especially of controversial geopolitical events, may contribute to growing social polarization. Existing research on “echo chambers”—fragmented information environments that amplify homogeneous perspectives—focuses on the degree to which individuals and social media platforms shape informational segregation. Here, we explore whether news organizations directly contribute to echo chambers through the hyperlinks they embed in online articles. Using network and text analysis, we examined coverage of the 2014 shooting of Michael Brown in Ferguson, MO, and found that online news media exhibited weak community structure and high connectivity across news outlets. However, analyses also indicated that media sources were more likely to link to coverage that was similar to their own in terms of emotional valence and stereotype-relevant aspects of the events. While hyperlinking to diverse news sources may ameliorate fragmented information environments, selectively linking to similar coverage may contribute to growing polarization.
Recent advances to accelerate re-endothelialization for vascular stents
Authors: Bedair Tarek M , ElNaggar Mahmoud A , Joung Yoon Ki , Han Dong Keun
Published: September 2017

Cardiovascular diseases are considered as one of the serious diseases that leads to the death of millions of people all over the world. Stent implantation has been approved as an easy and promising way to treat cardiovascular diseases. However, in-stent restenosis and thrombosis remain serious problems after stent implantation. It was demonstrated in a large body of previously published literature that endothelium impairment represents a major factor for restenosis. This discovery became the driving force for many studies trying to achieve an optimized methodology for accelerated re-endothelialization to prevent restenosis. Thus, in this review, we summarize the different methodologies opted to achieve re-endothelialization, such as, but not limited to, manipulation of surface chemistry and surface topography.
Response to George Gonzalez
Authors: Lundskow George , Langman Lauren
Published: September 2017

This response pertains to the review of our book, God Guns Gold and Glory—American Character and its Discontents, reviewed in this journal by George Gonzalez. Our response contends that the “review” is not really a critical reflection on our book, but something more like a dismissal. In essence, Gonzalez says that this is not the book he would have written; he wants to present his own thoughts, not critique ours.
Delivering value-for-money in PPPs? Risks and insights in change management
Authors: McCann Steven
Published: September 2017

A fundamental benefit sought from Public Private Partnerships is risk transfer – or more explicit allocation of risks between the public and private partners. However, not all operating risks can be transferred or eliminated. The public partner retains residual risk and remains ultimately accountable for the delivery of public services. Sub-standard management of major change events can lead to poor value-for-money outcomes. In-depth insights are provided in this article into how the actual management of Public Private Partnerships may be carried out and dealt with by governments at critical junctures during the concession period. Key risks, issues and critical success factors are identified that can have profound effects on the achievement of intended outcomes. These considerations build upon existing knowledge, policy and guidance for Public Private Partnerships, both nationally and internationally, making this essay tangible and grounded for both academics and practitioners.
Stop and Frisk Online: Theorizing Everyday Racism in Digital Policing in the Use of Social Media for Identification of Criminal Conduct and Associations
Authors: Patton Desmond Upton , Brunton Douglas-Wade , Dixon Andrea , Miller Reuben Jonathan , Leonard Patrick , Hackman Rose
Published: September 2017

Police are increasingly monitoring social media to build evidence for criminal indictments. In 2014, 103 alleged gang members residing in public housing in Harlem, New York, were arrested in what has been called “the largest gang bust in history.” The arrests came after the New York Police Department (NYPD) spent 4 years monitoring the social media communication of these suspected gang members. In this article, we explore the implications of using social media for the identification of criminal activity. We describe everyday racism in digital policing as a burgeoning conceptual framework for understanding racialized social media surveillance by law enforcement. We discuss implications for law enforcement agencies utilizing social media data for intelligence and evidence in criminal cases.
Why You Don’t See the Forest for the Trees When You Are Anxious: Anxiety Impairs Intuitive Decision Making
Authors: Remmers Carina , Zander Thea
Published: September 2017

Intuitive decisions arise effortlessly from an unconscious, associative coherence detection process. Hereby, they guide people adaptively through everyday life decision making. When people are anxious, however, they often make poor decisions or no decision at all. Is intuition impaired in a state of anxiety? The aim of the current experiment was to examine this question in a between-subjects design. A total of 111 healthy participants were randomly assigned to an anxious, positive, or neutral multimodal mood induction after which they performed the established semantic coherence task. This task operationalizes intuition as the sudden, inexplicable detection of environmental coherence, based on automatic, unconscious processes of spreading activation. The current findings show that anxious participants showed impaired intuitive performance compared to participants of the positive and neutral mood groups. Trait anxiety did not moderate this effect. Accordingly, holistic, associative processes seem to be impaired by anxiety. Clinical implications and directions for future research are discussed.
Morbidity in ≤1500-Gram Births in Spain, 1993-2011: Study of a Sample of 1200 Cases
Authors: Gómez Esteban Concepción , Sánchez Carrión Juan J. , García Selgas Fernando J. , Segovia Guisado José M.
Published: September 2017

Background and Objective. Preterm birth has a major impact on growth, and very preterm birth is associated with disabilities in numerous developmental domains. This article describes and quantifies morbidities in a sample of 1200 ≤1500-g births in Spain between 1993 and 2011 based on parent information, and it highlights several variables that influence these morbidities. Methods. Multiple method surveys using computer-assisted telephones interviewing and computer-assisted web interviewing methods. Sample design was intentional. Most subjects were contacted via their referral hospitals. Data collection was done from April 2013 to June 2014. Prior to the survey, extensive qualitative fieldwork was conducted, including nonparticipant observation in neonatal units and the design and analysis of discussion groups and interviews with professionals and families, including preterm adolescents. Results. A total of 44.2% of the sample were experiencing morbidity (mean: 1.788 morbidities per child). The most prevalent types were learning difficulties (34.4%) and attention deficit/hyperactivity disorder (31.5%). The most influential variables were male gender, age, lower birthweight, private hospital admission for birth, scarcity of health resources in the family’s residential area, non-Spanish maternal birthplace, and emotional distress in the primary carer. Conclusions. Overall, the total percentage of very low birth weight children with morbidities has decreased moderately between 1993 and 2011, thanks to major socio-sanitary improvements during this period. Biological and medical variables, rather than family factors, explain more accurately the presence of morbidities in children with birth weight ≤1500 g.
Multi-level differential network analysis of COPD exacerbations
Authors: Noell Guillaume , Cosío Borja G. , Faner Rosa , Monsó Eduard , Peces-Barba German , de Diego Alfredo , Esteban Cristobal , Gea Joaquim , Rodriguez-Roisin Robert , Garcia-Nuñez Marian , Pozo-Rodriguez Francisco , Kalko Susana G. , Agustí Alvar
Published: September 2017

Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation (ECOPD) that impact negatively the course of their disease. ECOPD are heterogeneous events of unclear pathobiology and non-specific diagnosis. Network analysis is a novel research approach that can help unravelling complex biological systems. We hypothesised that the comparison of multi-level (i.e., clinical, physiological, biological, imaging and microbiological) correlation networks determined during ECOPD and convalescence can yield novel patho-biologic information.

In this proof-of-concept study we included 86 patients hospitalised because of ECOPD in a multicentre study in Spain. Patients were extensively characterised both during the first 72 h of hospitalisation and during clinical stability, at least 3 months after hospital discharge.

We found that 1) episodes of ECOPD are characterised by disruption of the network correlation observed during convalescence; and 2) a panel of biomarkers that include increased levels of dyspnoea, circulating neutrophils and C-reactive protein (CRP) has a high predictive value for ECOPD diagnosis (AUC 0.97).

We conclude that ECOPD 1) are characterised by disruption of network homeokinesis that exists during convalescence; and 2) can be identified objectively by using a panel of three biomarkers (dyspnoea, circulating neutrophils and CRP levels) frequently determined in clinical practice.
Systems medicine advances in interstitial lung disease
Authors: Greiffo Flavia R. , Eickelberg Oliver , Fernandez Isis E.
Published: September 2017

Fibrotic lung diseases involve subject–environment interactions, together with dysregulated homeostatic processes, impaired DNA repair and distorted immune functions. Systems medicine-based approaches are used to analyse diseases in a holistic manner, by integrating systems biology platforms along with clinical parameters, for the purpose of understanding disease origin, progression, exacerbation and remission.

Interstitial lung diseases (ILDs) refer to a heterogeneous group of complex fibrotic diseases. The increase of systems medicine-based approaches in the understanding of ILDs provides exceptional advantages by improving diagnostics, unravelling phenotypical differences, and stratifying patient populations by predictable outcomes and personalised treatments. This review discusses the state-of-the-art contributions of systems medicine-based approaches in ILDs over the past 5 years.
Pulmonary hypertension in systemic sclerosis: different phenotypes
Authors: Launay David , Sobanski Vincent , Hachulla Eric , Humbert Marc
Published: September 2017

Pulmonary hypertension (PH) is a frequent and severe complication of systemic sclerosis (SSc). PH in SSc is highly heterogeneous because of the various clinical phenotypes of SSc itself and because the mechanisms of PH can vary from one patient to another. PH in SSc may be due to vasculopathy of the small pulmonary arteries (group 1; pulmonary arterial hypertension), interstitial lung disease (group 3; PH due to lung disease or chronic hypoxia) or myocardial fibrosis leading to left ventricular systolic or diastolic dysfunction (group 2; PH due to chronic left-heart disease). Pulmonary veno-occlusive disease is not uncommon in SSc and may also cause PH in some patients (group 1′). There is a high prevalence of each of these conditions in SSc and, as such, it may be difficult to determine the dominant cause of PH in a particular patient. However, careful phenotyping of PH in SSc is important as the therapy required for each of these underlying conditions is very different. In this review, we will decipher the different phenotypes of SSc-PH.
Personalised medicine in asthma: time for action
Authors: Chung Kian Fan
Published: September 2017

Asthma is a heterogeneous disease comprising several phenotypes driven by different pathways. To define these phenotypes or endotypes (phenotypes defined by mechanisms), an unbiased approach to clustering of various omics platforms will yield molecular phenotypes from which composite biomarkers can be obtained. Biomarkers can help differentiate between these phenotypes and pinpoint patients suitable for specific targeted therapies – the basis for personalised medicine. Biomarkers need to be linked to point-of-care biomarkers that may be measured readily in exhaled breath, blood or urine. The potential for using mobile healthcare approaches will help patient enpowerment, an essential tool for personalised medicine. Personalised medicine in asthma is not far off – it is already here, but we need more tools and implements to carry it out for the benefit of our patients.
Pharmacotherapy for idiopathic pulmonary fibrosis: current landscape and future potential
Authors: Raghu Ganesh
Published: September 2017

Over the past two and a half decades, many clinical trials have been designed to determine the safety and efficacy of pharmacotherapy for patients with idiopathic pulmonary fibrosis (IPF). However, so far, only two drugs (pirfenidone and nintedanib) have been found to have an impact on disease progression as defined by reducing the rate of decline in forced vital capacity over a year among IPF patients with mild to moderate impairment in lung function. These two drugs have been approved for treatment of IPF by regulatory agencies and are currently in clinical use worldwide. This article summarises the current landscape of pharmacotherapy for IPF and highlights the prospects and potential of new therapies that are currently being pursued in clinical trials.
The impact of saturation on seismic dispersion in shales — Laboratory measurements
Authors: Szewczyk Dawid , Holt Rune M. , Bauer Andreas
Published: September 2017

Previous studies found a significant increase of acoustic velocities between seismic and ultrasonic frequencies (seismic dispersion) for shales, which would have to be taken into account when comparing seismic or sonic field data with ultrasonic measurements in the laboratory. We have executed a series of experiments performed with a partially saturated Mancos shale and a Pierre shale I in which the influence of water saturation on acoustic velocities and seismic dispersion was investigated. The experiments were carried out in a triaxial setup allowing for combined measurements of quasistatic rock deformation, ultrasonic velocities, and dynamic elastic stiffness at seismic frequencies under deviatoric stresses. Prior to testing, the rock samples were preconditioned in desiccators at different relative humidities. For both shale types, we present and analyze the experimental results that demonstrate strong saturation and frequency dependence of dynamic Young’s moduli, Poisson’s ratios, and Thomsen’s anisotropy parameters, as well as P- and S-wave velocities at seismic and ultrasonic frequencies. The observed effects can be attributed to water adsorption and capillary pressure that are functions of several factors including water saturation. Water adsorption results in a reduction of surface energy and grain-contact stiffness. The capillary pressure affects the effective stress and possibly also the effective pore-fluid modulus, which may be approximated by Brie’s empirical model. Reasonable fits to the low-frequency seismic data are obtained by accounting for these two effects and applying the anisotropic Gassmann model. The strong increase in dispersion with increasing water saturation is attributed to local flow involving adsorbed (bound) water, but a quantitative description is yet to be provided.
Insulin-Deficient Mouseβ-Cells Do Not Fully Mature but Can Be Remedied Through Insulin Replacement by Islet Transplantation
Authors: Ramzy Adam , Mojibian Majid , Kieffer Timothy J
Published: September 2017

Insulin receptor (IR) insufficiency in β-cells leads to impaired insulin secretion and reduced β-cell hyperplasia in response to hyperglycemia. Selective IR deficiency in β-cells in later embryological development may lead to compensatory β-cell hyperplasia. Although these findings suggest insulin signaling on the β-cell is important for β-cell function, they are confounded by loss of signaling by the insulinlike growth factors through the IR. To determine whether insulin itself is necessary for β-cell development and maturation, we performed a characterization of pancreatic islets in mice with deletions of both nonallelic insulin genes (Ins1−/−Ins2−/−). We immunostained neonatal Ins1−/−Ins2−/− and Ins1+/+Ins2+/+ pancreata and performed quantitative polymerase chain reaction on isolated neonatal islets. Insulin-deficient islets had reduced expression of factors normally expressed in maturing β-cells, including muscoloaponeurotic fibrosarcoma oncogene homolog A, homeodomain transcription factor 6.1, and glucose transporter 2. Ins1−/−Ins2−/−β-cells expressed progenitor factors associated with stem cells or dedifferentiated β-cells, including v-myc avian myolocytomatosis viral oncogene lung carcinoma derived and homeobox protein NANOG. We replaced insulin by injection or islet transplantation to keep mice alive into adulthood to determine whether insulin replacement was sufficient for the completed maturation of insulin-deficient β-cells. Short-term insulin glargine (Lantus®) injections partially rescued the β-cell phenotype, whereas long-term replacement of insulin by isogenic islet transplantation supported the formation of more mature β-cells. Our findings suggest that tightly regulated glycemia, insulin species, or other islet factors are necessary for β-cell maturation.
Iatrogenic Transection of an Arterial Cannula and the Successful Use of Ultrasound to Locate the Retained Intraarterial Fragment: A Case Report
Authors: Leatherbarrow Andrew C. , Bucata Alina
Published: September 2017

We report a rare case of iatrogenic arterial cannula transection during a dressing change and migration of the distal fragment within the radial artery. The retained intraarterial fragment was successfully located using ultrasound, enabling swift surgical removal. We discuss the risk factors associated with arterial cannula transection and the efficacy of imaging modalities in locating the intraarterial fragment.
Overexpression of microRNA-722 fine-tunes neutrophilic inflammation through inhibiting Rac2 in zebrafish
Authors: Hsu Alan Yi-Hui , Wang Decheng , Gurol Theodore , Zhou Wenqing , Zhu Xiaoguang , Lu Hsiu-Yi , Deng Qing
Published: September 2017

Neutrophilic inflammation is essential for defending against invading pathogens, but can also be detrimental in many clinical settings. The hematopoietic-specific small Rho-GTPase Rac2 regulates multiple pathways that are essential for neutrophil activation, including adhesion, migration, degranulation and production of reactive oxygen species. This study tested the hypothesis that partially suppressing rac2 in neutrophils with a microRNA would inhibit neutrophil migration and activation, which will reduce the immunological damage caused by systemic inflammation. We have generated a transgenic zebrafish line that over-expresses microRNA-722 (miR-722) in neutrophils. Neutrophil motility and chemotaxis to tissue injury or infection are significantly reduced in this line. MiR-722 downregulates the transcript level of rac2 through binding to seed match in the rac2 3'UTR. Furthermore, miR-722 over-expressing larvae display improved outcomes in both sterile and bacterial systemic models, which correlates with a robust upregulation of the anti-inflammatory cytokines in the whole larvae and isolated neutrophils. Finally, the miR-722 mimics protect zebrafish from lethal LPS challenge. Together, we provide evidence and the mechanism of an anti-inflammatory microRNA that restrains detrimental systemic inflammation.
Arylboration of Internal Alkynes by Cooperative Palladium/Copper Catalysis
Authors: Semba Kazuhiko , Yoshizawa Megumi , Ohtagaki Yasuhiro , Nakao Yoshiaki
Published: September 2017

A versatile method for the arylboration of internal alkynes with aryl chlorides or bromides and bis(pinacolato)diboron has been developed. This method tolerates various functional groups, including acetyl, methoxycarbonyl, cyano, and fluoro substituents, and affords a range of tri-substituted vinylboronates, which are highly useful intermediates for the synthesis of tetra-substituted ethenes, in high yield and regioselectivity.
Gender Gaps and the Rise of the Service Economy
Authors: Ngai L. Rachel , Petrongolo Barbara
Published: September 2017

This paper investigates the role of the rise in services in the narrowing of gender gaps in hours and wages in recent decades. We highlight the between-industry component of differential gender trends for the United States and propose a model economy with goods, services, and home production, in which women have a comparative advantage in producing services. The rise of services, driven by structural transformation and marketization of home production, raises women's relative wages and market hours. Quantitatively, the model accounts for an important share of the observed trends in women's hours and relative wages. (JEL J16, J21, J22, J24, J31, L80)
Noisy News in Business Cycles
Authors: Forni Mario , Gambetti Luca , Lippi Marco , Sala Luca
Published: September 2017

We investigate the role of “noise” shocks as a source of business cycle fluctuations. To do so we set up a simple model of imperfect information and derive restrictions for identifying the noise shock in a VAR model. The novelty of our approach is that identification is reached by means of dynamic rotations of the reduced-form residuals. We find that noise shocks generate hump-shaped responses of GDP, consumption and investment, and account for a sizable fraction of their prediction error variance at business cycle horizons. (JEL C32, D83, E12, E23, E32, E43)
Monitoring the compliance of the academic enterprise with the Fair Labor Standards Act
Authors: Bankston Adriana , McDowell Gary S.
Published: September 2017

Background: On December 1, 2016, the Fair Labor Standards Act (FLSA) was due to be updated by the U.S. Department of Labor. Key changes included an increase in the salary threshold for exemption from overtime for working more than 40 hours per week, and indexing the salary level so that it is updated automatically every 3 years. This was predicted to have a profound effect on academe as postdoctoral researchers were mostly paid at a salary below the new threshold. On November 22, 2016, an injunction was granted nationwide, delaying implementation of the updates, which were finally struck down entirely on August 31, 2017. Here we review the key changes to the FLSA, how they came about, and how the postdoctoral population was affected.

Methods: We describe recent data collection efforts to uncover what institutions with postdocs were doing to comply with the FLSA.

Results: Our data showed that 57% of institutions checked (containing 41% of the estimated postdoctoral workforce in science, engineering and health) had not decided or had no public decision available one month prior to implementation, and only 35.5% of institutions were planning to raise salaries to the new minimum. After the injunction, a number of institutions and the NIH continued with their plans to raise salaries. Overall, despite the removal of a federal mandate, approximately 60% of postdocs are at institutions whose policy is to raise salaries.

Conclusions: Our data show uncertainty in postdoctoral salaries in the U.S. prior to implementation of the FLSA ruling. In addition, while some institutions did suspend plans to raise postdoctoral salaries after the injunction, many continued with the raise. The implementation of postdoctoral salary raises may be inconsistent, however, as the legal minimum is still $23,660.
Recent advances in eosinophilic esophagitis
Authors: Durrani Sandy , Rothenberg Marc
Published: September 2017

Eosinophilic esophagitis is a chronic, antigen-driven, eosinophil-predominant inflammatory disease of the esophagus and affects both children and adults. Cutting-edge technologies, such as genome-wide association studies, have advanced our understanding of the disease pathogenesis at a remarkable rate. Recent insights from genetic and mechanistic studies have concluded that a complex interplay between genetic and environmental risk factors, allergic sensitization, and esophageal-specific pathways leads to disease pathogenesis. Importantly, recent epidemiologic studies have found that the incidence and prevalence of eosinophilic esophagitis continue to rise. New guidelines have advocated the elimination of the term proton pump inhibitor (PPI)–responsive esophageal eosinophilia and have recommended using PPIs as a first-line treatment modality. Systemic reviews and meta-analyses confirm the efficacy of PPIs, topical corticosteroids, and empiric food elimination diets. Unmet needs include the development of birth cohort studies, validated diagnostic scoring systems, minimally invasive disease-monitoring methods, and the development of new therapies.
Immunoexpression of P63 and SOX2 in triple-negative breast cancers, Indonesia
Authors: Kamarlis Reno K , Lubis Muhammad ND , Hernowo Bethy S , Harapan Harapan , Kar Azmi S
Published: September 2017

Background: Using immunohistochemical stains to target specific breast cancer markers has become indispensable for evaluation of small diagnostic tissue specimens, and therefore novel marker cocktails for specific breast cancers are required. This study was conducted to assess the immunoexpression of P63 and SOX2 in triple negative breast cancer (TNBC), and to evaluate the predictive diagnostic value of these markers for specific types of TNBC.

Methods: Histological slides and paraffin blocks of TNBC cases were collected from Dr. Hasan Sadikin Hospital, Bandung, Indonesia from 5-years period (2011-2015). Each histological slide was subjected to immunohistochemical staining for P63 (nucleus and cytoplasm) and SOX2 (nucleus), with specific primer antibodies. Immunoexpression of P63 and SOX2 was evaluated using immunoreactivity scoring. Associations between P63 and SOX2 immunoexpression and TNBC types were assessed using Mann Whitney tests. In addition, the predictive diagnostic values of these markers were assessed.

Results: Forty TNBC histological slides were included, and 23 (57.5%) were Basal-like type TNBC and 17 (42.5%) were Non basal-like type TNBC. Immunoexpression of P63 nucleus and SOX2 was not different between types of TNBC. However, immunoexpression of P63 in the cytoplasm in Basal-like type TNBC was significantly higher than in Non basal-like type TNBC (p=0.021). Predictor diagnostic value analysis suggested that immunoexpression of P63 in cytoplasm had 56.5% sensitivity and 70.6% specificity for diagnosing Basal-like type TNBC, with area under curve of 0.64.   

Conclusions: Immunoexpression of P63 in the cytoplasm has a relatively weak diagnostic value to discriminate Basal-like and Non basal-like types of TNBC.
Regional system in the innovation development scenario: management aspect
Authors: Киянова Лилия , Kiyanova Liliya , Литвиненко Инна , Litvinenko Inna
Published: September 2017

The monograph is devoted to research of features of formation of innovative system of the region, given its typology. The authors focus on adaptability as the key principle of management of regional economic system. Taking into account the current situation and focus on the import substitution policy special attention during research is given to agriculture as a driver of socio-economic development of the regional system, as well as methods of increase of innovative activity in it. The publication is intended for teachers, graduate students, undergraduates, bachelors of economic directions of training, experts and other interested readers.
Accounting and tax accounting
Authors: Цыденова Эржэна , Cydenova Erzhena , Аюшиева Лариса , Ayushieva Larisa
Published: September 2017

The textbook consists of two sections. The first section reflects theoretical issues on accounting, the second section outlines the main provisions of tax accounting. This textbook contributes to the solution of the main task of economic education - the formation of students of modern type of economic thinking, knowledge of accounting and tax accounting, as well as the ability to master special economic terminology and vocabulary of this discipline. The textbook "Accounting and tax accounting" can be very useful in organizing self-education of students, it makes it possible to form skills of independent work with academic and scientific literature.
For students of higher education institutions and students of the system of additional professional education.
STRUCTURE AND PROPERTIES OF AZ31 MAGNESIUM ALLOY AFTER COMBINATION OF HOT EXTRUSION AND ECAP
Authors: Hilšer Ondřej , Rusz Stanislav , Maziarz Wojciech , Dutkiewicz Jan , Tański Tomasz , Snopiński Przemysław , Džugan Jan
Published: September 2017

Equal channel angular pressing (ECAP) method was used for achieving very fine-grained structure and increased mechanical properties of AZ31 magnesium alloy. The experiments were focused on the, in the initial state, hot extruded alloy. ECAP process was realized at the temperature 250°C and following route Bc. It was found that combination of hot extrusion and ECAP leads to producing of material with significantly fine-grained structure and improves mechanical properties. Alloy structure after the fourth pass of ECAP tool with helix matrix 30° shows a fine-grained structure with average grain size of 2 μm to 3 μm and high disorientation between the grains. More experimental results are discussed in this article.
MAGNETIC AND TRANSPORT PROPERTIES OF STAINLESS STEELS AT LOW TEMPERATURE
Authors: Nishimura Katsuhiko , Namiki Takahiro , Ikeno Tsuyoshi , Yamamoto Yuichi , Hutchison Wayne D.
Published: September 2017

Magnetic and transport properties of cold rolled SUS304 stainless steels were investigated via measurements of X-ray diffraction, magnetization, thermoelectric power (TEP), thermal conductivity and electrical resistivity from 300 K down to low temperatures. Saturation magnetizations at 300 K were 1.6, 37.5, 72.6 and 105.6 emu/g for rolled thickness reduction ratios of 0, 33, 50 and 75%, respectively. The thermoelectric power (TEP) values at 300 K were found to be -1.3, -0.4, 1.6 and 2.9 V/K for the reduction ratios of 0, 33, 50 and 75%, respectively. Least-squares fits of the experimental data predicted a saturation magnetization of 141 emu/g and a thermoelectric power of 4.3 V/K for SUS304 in the martensite phase at 300 K.
The three stages of courage in nursing
Authors: Price-Dowd Clare
Published: September 2017

Clare Price-Dowd, Senior Programme Lead, NHS Leadership Academy, Leeds, explores what courage means to her in the fourth blog in her ‘6 Cs of nursing’ series
Antioxidant and Cytotoxic Activities of Hot Water and Ethanol Extracts From Caesalpinia sappan
Authors: Park Mi-Hye , Kim Bumsik
Published: September 2017

Caesalpinia sappan L. is an oriental medicinal plant distributed in the Asia Pacific region including India, Malaysia, and China. The dried heartwood of Caesalpinia sappan has been traditionally used as an analgesic and anti-inflammatory drug. In this study, the effects of extract methods of C. sappan on contents of total polyphenols and flavonoids, antioxidant activity, and cytotoxic activity were evaluated. As a result, hot water extract from C. sappan (CSWE) significantly exhibited contents of total polyphenols and flavonoids (22.6 mg GAE/g and 14.5 mg QE/g) higher than 70% ethanol extract (CSEE) (17.6 mg GAE/g and 13.2 mg QE/g). However, CSEE showed greater antioxidant activity than CSWE in both DPPH and ABTS. Also, the cytotoxicity of C. sappan against three kinds of cancer cell lines was higher in CSEE than in CSWE. These results show that ethanol extract is a better extract method than hot water method to maintain antioxidant and anti-cancer activities.
Oral Bioavailability for Sub-micron Particle Curcumin (TheracurminCR-033P) and Absorption Rate by Product Composition in Healthy Human Volunteers
Authors: Park Hee Jung , Tsukasa Takahashi , Hitomi Ozawa
Published: September 2017

Curcumin have various health-beneficial properties in numerous studies. However, its bioavailability is low due to its limited intestinal uptake and rapid metabolism. This study aimed to evaluate the pharmacokinetics of newly developed sub-micron particle curcumin with increased water dispersibility (Theracurmin® CR-033P). Plasma curcumin levels were measured at 0, 1, 2, 4, 8 h after Theracurmin® CR-033P intake using high-performance liquid chromatography. For analyzing pharmacokinetics of Theracurmin® CR-033P, eighteen healthy subjects were recruited and received Theracurmin® CR-033P at a single oral dose containing curcumin 30 mg. Cmax was 28.14 ng/ml, and the area under the curve for 8 h was estimated to be 104.36 ng/ml. Based on the area under the plasma concentration (AUC), the bioavailability of sub-micron particle curcumin was higher 22-, 35-, 28-fold than native curcumin in men, women, and all subjects, respectively. For comparing by formulation, seven healthy subjects were recruited and received two type of treatment: (1) existing dosage form 300 mg (contained curcumin 30 mg) × 3 capsule, (2) high dosage form 300 mg (contained curcumin 90 mg) × 1 capsule + placebo 300 mg × 2 capsule. In the cross-over study, there was no significant differences in Cmax and AUC of plasma curcumin. In conclusion, submicron particle curcumin with increased water dispersibility significantly improved its oral bioavailability and women absorbed curcumin more effectively than men. Different formulation of Theracurmin® CR-033P has shown equivalent to the reference in terms of pharmacokinetics.
Black Suffering for/from Anti-trafficking Advocacy
Authors: Beutin Lyndsey P.
Published: September 2017

This article analyses the images that Antislavery Usable Past creates to promote its cause of ‘making the antislavery past usable for contemporary abolition’. Drawing on collective memory studies, I discuss the political implications of how pasts are used for present issues. I argue that Antislavery Usable Past appropriates black suffering by reducing the memory and imagery of slavery to objects that are compatible with the anti-trafficking narrative, without regard for the ongoing black liberation struggle. I conclude by discussing the troubling trend of incorporating anti-trafficking exhibitions into institutions that preserve the history of slavery and abolition. Such inclusions redirect the history lessons of slavery away from understanding and addressing anti-blackness in the present and towards supporting advocacy campaigns articulated in the logics that underpinned racial chattel slavery in the first place.
El rol de la família en la literatura infantil i juvenil del segle XXI: el desenvolupament de la competència lectora intercultural a través d’un àlbum il·lustrat
Authors: Domene Benito Rocío
Published: September 2017

Tradicionalment la família ha estat un dels temes més adreçats als xiquets. En aquest sentit, el principal objectiu d’aquest article serà la reformulació del terme família al voltant dels nous models, com el que es mostra a l’àlbum il·lustrat In Our Mothers’ House (2009). A través de la història d’una família allunyada dels cànons tradicionals, explorarem com tracta Polacco el tema de la família i la interculturalitat atenent al gran valor que adquireix en la formació dels alumnes com a éssers humans. Representa, per tant, una eina eficaç i útil per a mostrar als estudiants que no existeix un únic concepte de família, així com la rellevància de la interculturalitat al món que els envolta. A més a més, promoure la competència literària i lectora intercultural en el segle XXI convida els alumnes a pensar d’una manera crítica i reflexiva, i fomenta la seua imaginació i creativitat. En conclusió, mitjançant un àlbum il·lustrat es pot afavorir el desenvolupament del xiquet no sols en àrees lingüístiques, literàries i cognitives sinó també morals i cíviques.