bluuebunny/crossref_metadata_2025 huggingface dataset:
Noble Metal Promoted TiO2 from Silver-Waste Valorisation: Synergism between Ag and Au
Authors: Stucchi Marta , Meroni Daniela , Safran György , Villa Alberto , Bianchi Claudia L. , Prati Laura
Published: February 2022

Wastewaters from precious metal industries contain high amounts of noble metals, but their efficient recycling is hindered by the wastewater complex composition. Here, we propose an innovative approach for the efficient recovery of noble metals contained in these metal-enriched wastewaters as precursors for the synthesis of noble metal nanoparticles (NPs) and supported metal catalysts. Silver NPs were synthesized from Ag-enriched wastewater and then deposited on TiO2 to prepare photocatalysts. Then, further promotion of the photocatalytic activity of Ag-modified TiO2 was achieved by the addition of as little as 0.5 wt.% of Au. STEM-EDS analyses proved that Au NPs were located on Ag or AgOx nanoparticles. The contact between the two metal-containing NPs results in charge transfer effects, appreciable both in terms of oxidation states determined by XPS and of optical properties. In particular, the plasmon band of Au NPs shows photochromic effects: under UV light irradiation, bimetallic samples exhibit a blue-shift of the plasmon band, which is reversible under dark storage. The activity of the materials was tested towards ethanol photodegradation under UV light. Adding 0.5 wt.% Au NPs resulted in a promoted activity compared to Ag-TiO2, thus showing synergistic effects between Au and Ag. Ethanol was completely converted already after 1 h of UV irradiation, acetaldehyde was formed as the main oxidation product and fully degraded in less than 180 min. Notably, bimetallic samples showed ethylene formation by a parallel dehydration mechanism.
Oxygen Vacancy-Mediated Selective H2S Oxidation over Co-Doped LaFexCo1−xO3 Perovskite
Authors: Yu Xinlei , Tao Xun , Gao Yunfei , Ding Lu , Wang Yanqin , Yu Guangsuo , Wang Fuchen
Published: February 2022

Compared to the Claus process, selective H2S catalytic oxidation to sulfur is a promising reaction, as it is not subject to thermodynamic limitations and could theoretically achieve ~100% H2S conversion to sulfur. In this study, we investigated the effects of Co and Fe co-doping in ABO3 perovskite on H2S selective catalytic oxidation. A series of LaFexCo1−xO3 (x = 0, 0.2, 0.4, 0.6, 0.8, 1.0) perovskites were synthesized by the sol-gel method. Compared to LaFeO3 and LaCoO3, co-doped LaFexCo1−xO3 significantly improved the H2S conversion and sulfur selectivity at a lower reaction temperature. Nearly 100% sulfur yield was achieved on LaFe0.4Co0.6O3 under 220 °C with exceptional catalyst stability (above 95% sulfur yield after 77 h). The catalysts were characterized by XRD, BET, FTIR, XPS, and H2-TPR. The characterization results showed that the structure of LaFexCo1−xO3 changed from the rhombic phase of LaCoO3 to the cubic phase of LaFeO3 with Fe substitution. Doping with appropriate iron (x = 0.4) facilitates the reduction of Co ions in the catalyst, thereby promoting the H2S selective oxidation. This study demonstrates a promising approach for low-temperature H2S combustion with ~100% sulfur yield.
Production of Jet Biofuels by Catalytic Hydroprocessing of Esters and Fatty Acids: A Review
Authors: Monteiro Rodolpho R. C. , dos Santos Isabela A. , Arcanjo Maria R. A. , Cavalcante Célio L. , de Luna Francisco M. T. , Fernandez-Lafuente Roberto , Vieira Rodrigo S.
Published: February 2022

The transition from fossil to bio-based fuels is a requisite for reducing CO2 emissions in the aviation sector. Jet biofuels are alternative aviation fuels with similar chemical composition and performance of fossil jet fuels. In this context, the Hydroprocessing of Esters and Fatty Acids (HEFA) presents the most consolidated pathway for producing jet biofuels. The process for converting esters and/or fatty acids into hydrocarbons may involve hydrodeoxygenation, hydrocracking and hydroisomerization, depending on the chemical composition of the selected feedstock and the desired fuel properties. Furthermore, the HEFA process is usually performed under high H2 pressures and temperatures, with reactions mediated by a heterogeneous catalyst. In this framework, supported noble metals have been preferably employed in the HEFA process; however, some efforts were reported to utilize non-noble metals, achieving a similar performance of noble metals. Besides the metallic site, the acidic site of the catalyst is crucial for product selectivity. Bifunctional catalysts have been employed for the complete process of jet biofuel production with standardized properties, with a special remark for using zeolites as support. The proper design of heterogeneous catalysts may also reduce the consumption of hydrogen. Finally, the potential of enzymes as catalysts for intermediate products of the HEFA pathway is highlighted.
Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription
Authors: DeMarino Catherine , Cowen Maria , Khatkar Pooja , Cotto Bianca , Branscome Heather , Kim Yuriy , Sharif Sarah Al , Agbottah Emmanuel T. , Zhou Weidong , Costiniuk Cecilia T. , Jenabian Mohammad-Ali , Gelber Cohava , Liotta Lance A. , Langford Dianne , Kashanchi Fatah
Published: February 2022

Of the 37.9 million individuals infected with human immunodeficiency virus type 1 (HIV-1), approximately 50% exhibit HIV-associated neurocognitive disorders (HAND). We and others previously showed that HIV-1 viral RNAs, such as trans-activating response (TAR) RNA, are incorporated into extracellular vesicles (EVs) and elicit an inflammatory response in recipient naïve cells. Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), the primary cannabinoids present in cannabis, are effective in reducing inflammation. Studies show that cannabis use in people living with HIV-1 is associated with lower viral load, lower circulating CD16+ monocytes and high CD4+ T-cell counts, suggesting a potentially therapeutic application. Here, HIV-1 infected U1 monocytes and primary macrophages were used to assess the effects of CBD. Post-CBD treatment, EV concentrations were analyzed using nanoparticle tracking analysis. Changes in intracellular and EV-associated viral RNA were quantified using RT-qPCR, and changes in viral proteins, EV markers, and autophagy proteins were assessed by Western blot. Our data suggest that CBD significantly reduces the number of EVs released from infected cells and that this may be mediated by reducing viral transcription and autophagy activation. Therefore, CBD may exert a protective effect by alleviating the pathogenic effects of EVs in HIV-1 and CNS-related infections.
Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis
Authors: Rovati Gianenrico , Contursi Annalisa , Bruno Annalisa , Tacconelli Stefania , Ballerini Patrizia , Patrignani Paola
Published: February 2022

Metastasis requires that cancer cells survive in the circulation, colonize distant organs, and grow. Despite platelets being central contributors to hemostasis, leukocyte trafficking during inflammation, and vessel stability maintenance, there is significant evidence to support their essential role in supporting metastasis through different mechanisms. In addition to their direct interaction with cancer cells, thus forming heteroaggregates such as leukocytes, platelets release molecules that are necessary to promote a disseminating phenotype in cancer cells via the induction of an epithelial–mesenchymal-like transition. Therefore, agents that affect platelet activation can potentially restrain these prometastatic mechanisms. Although the primary adhesion of platelets to cancer cells is mainly independent of G protein-mediated signaling, soluble mediators released from platelets, such as ADP, thromboxane (TX) A2, and prostaglandin (PG) E2, act through G protein-coupled receptors (GPCRs) to cause the activation of more additional platelets and drive metastatic signaling pathways in cancer cells. In this review, we examine the contribution of the GPCRs of platelets and cancer cells in the development of cancer metastasis. Finally, the possible use of agents affecting GPCR signaling pathways as antimetastatic agents is discussed.
Characterization of Collapsin Response Mediator Protein 2 in Colorectal Cancer Progression in Subjects with Diabetic Comorbidity
Authors: Chang Yih-Hsin , Yang Hui-Ju , Chen Huan-Wen , Hsiao Chiao-Wan , Hsieh Yi-Chen , Chan Yu-Wei , Chang Shu-Wen , Hwang Wei-Lun , Chen Wei-Shone , Cheng Hou-Hsuan , Chou Teh-Ying , Chang Fu-Pang , Ho Hsiang-Ling , Chu Fang-Yeh , Lo Yu-Li , Chen Chun-Jung , Tsai Hui-Fang , Shiau Ming-Yuh
Published: February 2022

Background: Common demographic risk factors are identified in colorectal cancer (CRC) and type 2 diabetes mellitus (DM), nevertheless, the molecular link and mechanism for CRC-DM comorbidity remain elusive. Dysregulated glycogen synthase kinase-3 beta under metabolic imbalance is suggested to accelerate CRC pathogenesis/progression via regulating collpasin response mediator protein-2 (CRMP2). Accordingly, roles of CRMP2 in CRC and CRC-DM patients were investigated for elucidating the molecular convergence of CRC and DM. Methods: CRMP2 profile in tumor tissues from CRC and CRC-DM patients was investigated to explore the link between CRC and DM etiology. Meanwhile, molecular mechanism of glucose to regulate CRMP2 profile and CRC characteristics was examined in vitro and in vivo. Results: CRMP2 was significantly lower in tumor lesions and associated with advanced tumor stage in CRC-DM patients. Physiological hyperglycemia suppressed CRMP2 expression/activity and augmented malignant characteristics of CRC cells. Hyperglycemia promotes actin de-polymerization, cytoskeleton flexibility and cell proliferation/metastasis by downregulating CRMP2 profile and thus contributes to CRC disease progression. Conclusions: This study uncovers molecular evidence to substantiate and elucidate the link between CRC and T2DM, as well as characterizing the roles of CRMP2 in CRC-DM. Accordingly, altered metabolic adaptations are promising targets for anti-diabetic and cancer strategies.
Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity
Authors: Parrillo Luca , Spinelli Rosa , Costanzo Mattia , Florese Pasqualina , Cabaro Serena , Desiderio Antonella , Prevenzano Immacolata , Raciti Gregory Alexander , Smith Ulf , Miele Claudia , Formisano Pietro , Napoli Raffaele , Beguinot Francesco
Published: February 2022

Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well before diabetes onset. The molecular mechanisms linking these events have only partially been clarified. In the present report, we show that silencing of the transcription factor Homeobox A5 (HOXA5) in human preadipocytes impaired differentiation in mature adipose cells in vitro. The reduced adipogenesis was accompanied by inappropriate WNT-signaling activation. Importantly, in preadipocytes from FDR individuals, HOXA5 expression was attenuated, with hypermethylation of the HOXA5 promoter region found responsible for its downregulation, as revealed by luciferase assay. Both HOXA5 gene expression and DNA methylation were significantly correlated with SAT adipose cell hypertrophy in FDR, whose increased adipocyte size marks impaired adipogenesis. In preadipocytes from FDR, the low HOXA5 expression negatively correlated with enhanced transcription of the WNT signaling downstream genes NFATC1 and WNT2B. In silico evidence indicated that NFATC1 and WNT2B were directly controlled by HOXA5. The HOXA5 promoter region also was hypermethylated in peripheral blood leukocytes from these same FDR individuals, which was further revealed in peripheral blood leukocytes from an independent group of obese subjects. Thus, HOXA5 controlled adipogenesis in humans by suppressing WNT signaling. Altered DNA methylation of the HOXA5 promoter contributed to restricted adipogenesis in the SAT of lean subjects who were FDR of type 2 diabetics and in obese individuals.
Species-Specific Paternal Age Effects and Sperm Methylation Levels of Developmentally Important Genes
Authors: Prell Andreas , Sen Mustafa Orkun , Potabattula Ramya , Bernhardt Laura , Dittrich Marcus , Hahn Thomas , Schorsch Martin , Zacchini Federica , Ptak Grazyna Ewa , Niemann Heiner , Haaf Thomas
Published: February 2022

A growing number of sperm methylome analyses have identified genomic loci that are susceptible to paternal age effects in a variety of mammalian species, including human, bovine, and mouse. However, there is little overlap between different data sets. Here, we studied whether or not paternal age effects on the sperm epigenome have been conserved in mammalian evolution and compared methylation patterns of orthologous regulatory regions (mainly gene promoters) containing both conserved and non-conserved CpG sites in 94 human, 36 bovine, and 94 mouse sperm samples, using bisulfite pyrosequencing. We discovered three (NFKB2, RASGEF1C, and RPL6) age-related differentially methylated regions (ageDMRs) in humans, four (CHD7, HDAC11, PAK1, and PTK2B) in bovines, and three (Def6, Nrxn2, and Tbx19) in mice. Remarkably, the identified sperm ageDMRs were all species-specific. Most ageDMRs were in genomic regions with medium methylation levels and large methylation variation. Orthologous regions in species not showing this age effect were either hypermethylated (>80%) or hypomethylated (<20%). In humans and mice, ageDMRs lost methylation, whereas bovine ageDMRs gained methylation with age. Our results are in line with the hypothesis that sperm ageDMRs are in regions under epigenomic evolution and may be part of an epigenetic mechanism(s) for lineage-specific environmental adaptations and provide a solid basis for studies on downstream effects in the genes analyzed here.
Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease
Authors: Kshirsagar Sudhir , Alvir Rainier Vladlen , Hindle Ashly , Kumar Subodh , Vijayan Murali , Pradeepkiran Jangampalli Adi , Reddy Arubala P. , Ramasubramanian Bhagavathi , Reddy P. Hemachandra
Published: February 2022

The purpose of our study is to investigate early cellular, molecular, morphological and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month-old homozygous hAbKI mice, we studied behavioral phenotype parameters, including spatial learning and memory (Morris Water Maze), locomotor activity (open field), working memory (Y-maze) and motor coordination (rotarod); mRNA abundance, protein levels, soluble amyloid-beta 40 and 42 levels and regional immunoreactivities of key markers of mitochondrial dynamics, mitochondrial biogenesis, synaptic health, mitophagy and autophagy; mitochondrial function and using transmission electron microscopy & Golgi–Cox staining, we assessed mitochondrial morphology and dendritic spines. Our extensive behavioral analysis revealed that seven-month-old hAbKI mice showed impairments in motor coordination, reduced locomotor and exploration activities, impairments in working memory and spatial learning and memory. Our mRNA and protein analyses revealed the increased expression of mitochondrial-fission genes and reduced expression of mitochondrial-fusion, mitochondrial-biogenesis, synaptic, autophagy and mitophagy genes in seven-month-old hAbKI mice. An immunofluorescence analysis revealed altered immunoreactivities and agreed with the immunoblot results. Transmission-electron-microscopy data revealed increased mitochondrial fragmentation and reduced mitochondrial length in both hippocampal and cortical tissues of seven-month-old hAbKI mice and mitochondrial function defective. A Golgi–Cox-staining analysis revealed reduced dendritic spines in both cerebral cortices and hippocampi of hAbKI mice. Soluble amyloid-beta (1–40 and 1–42) were detected in three-month-old hAbKI mice and progressively increased in seven-month-old mice. These observations suggest that the human amyloid-beta peptide is sufficient to cause behavioral, mitochondrial, synaptic and ultrastructural changes in seven-month-old hAbKI mice. Our study findings also suggest that hAbKI mice might serve as a model for preclinical studies of preventive therapies.
Health-Related Quality of Life Assessments by Children and Adolescents with Sickle Cell Disease and Their Parents in Portugal
Authors: Abadesso Clara , Pacheco Susana , Machado Maria Céu , Finley G. Allen
Published: February 2022

Health-Related Quality of Life (HRQL) can be used to measure the impact of Sickle Cell Disease (SCD) on the child and their family and is generally reduced. No research has yet measured HRQL in Portuguese pediatric SCD patients. Objectives: (1) Describe and compare HRQL of children with SCD reported by them and their parents; (2) Compare with a pediatric population with no SCD; (3) Find predictive factors of HRQL in SCD children. Methods: Descriptive, case-control study that included sixty-eight children and adolescents with SCD (aged 3 to 18 years) and their parents. Control group—children with no SCD, matched by age, gender and ethnic background. HRQL was assessed using the multidimensional self-report PedsQL® 4.0 Generic Scales. Summary scores for overall HRQL and subscale scores for physical, emotional, social and school functioning were compared within groups (children-parents) and with the control group. Clinical and socio-demographic variables were analyzed to find predictive factors of HRQL in pediatric SCD patients. Results: Children with SCD and their parents had significantly lower overall and all subdomains of HRQL, compared with the control group. Children with SCD also rated lower when compared with their parents (only significant for social functioning), with low to moderate correlations. Children and parent reports declined with increasing age. Higher pain frequency was associated with worse total and psychosocial domains of HRQL. The number of hospitalizations was a predictor of worse school score, and female gender was a predictor of worse emotional score. Conclusions: SCD significantly affects children’s HRQL. Parents can provide a good proxy report, although both evaluations are beneficial. Disease status, like number of hospitalizations and frequency of pain, influences HRQL. Interventions in SCD should consider improvements in HRQL as an important outcome.
Foam Splint versus Spica Cast—Early Mobilization after Hip Reconstructive Surgery in Children—Preliminary Data from a Prospective Randomized Clinical Trial
Authors: Pisecky Lorenz , Großbötzl Gerhard , Gahleitner Manuel , Stadler Christian , Stevoska Stella , Haas Christina , Gotterbarm Tobias , Klotz Matthias Christoph Michael
Published: February 2022

Background: Surgical hip joint reconstruction may be the method of choice for children and adolescents with developmental dysplasia of the hip (DDH), as well as neurogenic dislocation of the hip (NDH) and Legg–Calvé–Perthes disease (LCPD). Following pelvic surgery, immobilization using a spica cast is considered to be the gold standard, despite the fact that casting may cause complications, such as hygienic problems, skin lesions, neurological deficits, and rigidity of the adjacent joints. An alternative for postoperative immobilization is a foam splint. The purpose of this randomized controlled trial was to compare spica cast and foam splint immobilization after hip reconstruction in children and adolescents with DDH, NDH, and LCPD. Methods: In a prospective randomized clinical trial, children and adolescents (age: 4–14 years), who received hip reconstructive surgery (osteotomy of the ilium and proximal femur, open reduction, soft tissue techniques) for DDH, NDH, and LCPD were included. Patient recruitment, group allocation, surgery, and aftercare were carried out in a department for orthopaedic surgery in Central Europe. Standardized questionnaires SF-36 (Short Form-36), EQ-5D (Euro Quality of Life 5D and CPCHILD (Caregiver Priorities and Child Health Index of Life with Disabilities) were gathered before, six, and twelve weeks after surgery from each patient. Group one received a spica cast and group two a foam splint for a period of six weeks postoperatively. There was no difference in surgical treatment. Results: Twenty-one out of thirty planned patients were enrolled in the study. One patient had to be excluded because of a lack of compliance. All quality of life (QOL) scores showed a significant reduction at the 6-week follow-up compared to the preoperative assessment. After twelve weeks, the scores came back close to the preoperative values. A significant reduction was seen in the spica cast group pre- vs. postoperatively for the variables CPCHILD (81% vs. 64%, p = 0.001), EQ-5d (65% vs. 45%, p = 0.014), and SF-36 (85% vs. 74%, p = 0.004). The corresponding values for the foam splint group also presented a reduction for all scores, but without statistical significance. Complications occurred in five cases. Conclusions: Recent retrospective studies suggest that foam splint immobilization after hip reconstruction surgery is a safe and feasible method, promising fewer complications compared to spica casting. The preliminary results of this prospective randomized clinical trial show an improvement of the scores when using a foam splint compared to the conventionally used spica cast. Benefits for the patients may be fewer adverse events and no need to undergo a second round of anaesthesia for recasting. Data suggest higher patient and caretaker satisfaction in the foam splint group.
Evolution Law and Mechanism of Freeze–Thaw Damage of Cement-Stabilized Weathered Sand
Authors: Kong Xianghui , Cui Shuai , Wang Gaoqiang , Hu Wenjun , Liang Yunpeng , Zhang Zhibin
Published: February 2022

To explore the damage evolution law of cement-stabilized weathered sand under the action of freeze–thaw cycles, relevant experimental research was carried out on stabilized weathered sand with a cement content of 3%, including unconfined compressive strength (UCS), scanning electron microscope (SEM), and mercury intrusion porosimetry (MIP) testing. Using the surface appearance, mass, and UCS of the specimen, combined with the changes of microscopic characteristics, the freeze–thaw damage law and microscopic degradation mechanism of cement-stabilized weathered sand were analyzed. The test results showed that with the increase of the number of freeze–thaw cycles, the surface appearance of the specimen continued to deteriorate, the unconfined compressive strength gradually decreased, and the mass of the specimen first increased and then decreased. After nine freeze–thaw cycles, the specimen was seriously damaged, and the strength loss was as high as 55%. From a microscopic point of view, the freeze–thaw cycles caused the pore water inside the specimen to continuously change between ice crystals and liquid. Frost heave and shrinkage weakened the cement bond between the weathered sand particles and made the pores in the specimen develop and expand continuously. With the decrease of the number of micropores and the increase of the number of medium and large pores, the particle skeleton changed from a dense structure to a porous structure, which eventually led to the deterioration of the macroscopic properties of the cement-stabilized weathered sand.
Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers
Authors: Guzmán Eduardo
Published: February 2022

Pollution is currently a public health problem associated with different cardiovascular and respiratory diseases. These are commonly originated as a result of the pollutant transport to the alveolar cavity after their inhalation. Once pollutants enter the alveolar cavity, they are deposited on the lung surfactant (LS) film, altering their mechanical performance which increases the respiratory work and can induce a premature alveolar collapse. Furthermore, the interactions of pollutants with LS can induce the formation of an LS corona decorating the pollutant surface, favoring their penetration into the bloodstream and distribution along different organs. Therefore, it is necessary to understand the most fundamental aspects of the interaction of particulate pollutants with LS to mitigate their effects, and design therapeutic strategies. However, the use of animal models is often invasive, and requires a careful examination of different bioethics aspects. This makes it necessary to design in vitro models mimicking some physico-chemical aspects with relevance for LS performance, which can be done by exploiting the tools provided by the science and technology of interfaces to shed light on the most fundamental physico-chemical bases governing the interaction between LS and particulate matter. This review provides an updated perspective of the use of fluid films of LS models for shedding light on the potential impact of particulate matter in the performance of LS film. It should be noted that even though the used model systems cannot account for some physiological aspects, it is expected that the information contained in this review can contribute on the understanding of the potential toxicological effects of air pollution.
Temperature-Resolved Anisotropic Displacement Parameters from Theory and Experiment: A Case Study
Authors: Mroz Damian , Wang Ruimin , Paulmann Carsten , Englert Ulli , Dronskowski Richard
Published: February 2022

Anisotropic displacement parameters (ADPs) for an organopalladium complex were obtained from synchrotron diffraction data between 100 and 250 K and compared to the results from first-principles calculations at the harmonic approximation. Calculations and experiments agree with respect to the orientation of displacement ellipsoids and hence the directionality of atomic movement, but the harmonic approximation underestimates the amplitudes of motion by about 20%. This systematic but modest underestimation can only be reliably detected with a high-quality experimental benchmark at hand. Our experiments comprised diffraction data at 20 K intervals from 130–250 K on the same crystal. An additional high-resolution data set was collected at 100 K on a second crystal and underlined the robustness of our approach with respect to the individual sample, resolution, and instrumentation. In the temperature range relevant for our study and for many diffraction experiments, the discrepancy between experimentally determined and calculated displacement appears as an almost constant temperature offset. The systematic underestimation of harmonic theory can be accounted for by calculating the ADPs for a temperature 20 K higher than that of the actual diffraction. This entirely empirical “+20 K rule” lacks physical relevance but may pave the way for application in larger systems where a more reliable quasi-harmonic approximation remains computationally demanding or even entirely unaffordable.
Unconfined Compressive Strength and Splitting Tensile Strength of Lime Soil Modified by Nano Clay and Polypropylene Fiber
Authors: Jiang Ping , Zhou Lin , Zhang Weiqing , Wang Wei , Li Na
Published: February 2022

Here we study the effects of nano clay and polypropylene fiber on the unconfined compression and splitting properties of lime soil. Through a series of unconfined compressive strength (UCS) tests and splitting strength (STS) tests, the mechanical properties of lime soil (LS), nano clay modified lime soil (NLS), fiber modified lime soil (FLS), nano clay and fiber composite modified lime soil (NFLS) are analyzed, and the volume calculation formula of each phase in NFLS is deduced. Nano clay content αn, porosity volume η and lime volume LVi as independent variables, and the prediction models of UCS and STS of NFLS were established. Furthermore, the microstructure of LS, NLS, FLS and NFLS was analyzed by scanning electron microscope (SEM). It can be concluded that (1) with the increase in nano clay content, the UCS and STS of LS and FLS gradually increase. With the increase in fiber content, the UCS of LS first increases and then decreases, while the UCS and STS of NLS and STS of LS increase with the increase in fiber content, and the optimal fiber content is 0.75%. (2) UCS and STS of NFLS and η/LVi meet the linear relationship. The empirical formulas of UCS and STS established in this paper have a prediction accuracy of less than 10%. The strength of NFLS can be predicted according to the dry density of the sample and the content of each component material. (3) Nano clay can fill the pores of LS and promote the pozzolanic reaction between lime and soil, while fiber mainly plays a reinforcing role in LS, so as to improve the UCS and STS of LS. In NFLS, nano clay can improve the interfacial properties between fiber and LS, so as to improve its UCS and STS. This study can provide a reference for the modification technology of lime soil.
Enhanced Light Extraction Efficiency and Modulation Bandwidth of Deep-Ultraviolet Light-Emitting Diodes with Al Nanospheres
Authors: Hu Xiaolong , Liang Xu , Tang Lingyun , Liu Wenjie
Published: February 2022

Planar, nanopillar and Al nanosphere structure AlGaN-based deep-ultraviolet light-emitting diodes (DUV-LEDs) were numerically investigated via a three-dimensional finite difference time domain (3D FDTD) method. The three types of DUV-LEDs were compared and analyzed in terms of light extraction efficiency (LEE), Purcell factor (FP) and modulation bandwidth. The results showed that nanopillar structure DUV-LEDs with optimal nanopillar height, width and spacing can enhance transverse electric (TE)-polarized LEE to 39.7% and transverse magnetic (TM)-polarized LEE to 4.4%. The remarkable improvement was mainly due to the increased scattering effect, decreased absorption of the p-GaN layer and total internal reflection (TIR) effect. After adopting the Al nanospheres, the TE-polarized modulation bandwidth was increased by 71 MHz and the TM-polarized LEE was enhanced approximately 4.3-fold as compared to the nanopillar LED structure, while the Al nanosphere diameter was 120 nm. The reasons for promotion are mainly attributed to the coupling behavior of diploe and localized surface plasmon induced by Al nanospheres. The designed structures provide a meaningful solution for realization of high-efficiency DUV-LEDs.
Investigation of the Flow Behavior of Air-Cooling Ti-6Al-4V Alloy after Superplastic Forming
Authors: Han Xiaoning , Yang Junzhou , Li Jinshan , Wu Jianjun
Published: February 2022

The flow behavior of Ti-6Al-4V alloy during the air-cooling process after superplastic forming (SPF) has been discussed. In high-temperature constant strain rate tensile tests, the selected temperatures were 930, 900, 800, 700, and 600 °C, and the initial strain rates were 10−2, 10−3, and 10−4/s. The optimized deformation temperatures were 800~900 °C and the strain rates were 10−4~10−3/s. Then, the evolutions of activation energy and deformation strain are also discussed, and the effects of dislocation density and deformation activation energy on flow behavior were consistent. In addition, unstable flow is mainly concentrated in the low-temperature and high strain-rate regions, and this is mainly caused by dynamic recrystallization (DRX). After the SPF process, the possibility of material damage gradually increases during the air-cooling process.
Channel Mobility Model of Nano-Node MOSFETs Incorporating Drain-and-Gate Electric Fields
Authors: Chao Shou-Yen , Huang Heng-Sheng , Huang Ping-Ray , Lin Chun-Yeon , Wang Mu-Chun
Published: February 2022

A novel channel mobility model with two-dimensional (2D) aspect is presented covering the effects of source/drain voltage (VDS) and gate voltage (VGS), and incorporating the drift and diffusion current on the surface channel at the nano-node level, at the 28-nm node. The effect of the diffusion current is satisfactory to describe the behavior of the drive current in nano-node MOSFETs under the operations of two-dimensional electrical fields. This breakthrough in the model’s establishment opens up the integrity of long-and-short channel devices. By introducing the variables VDS and VGS, the mixed drift and diffusion current model effectively and meaningfully demonstrates the drive current of MOSFETs under the operation of horizontal, vertical, or 2D electrical fields. When comparing the simulated and experimental consequences, the electrical performance is impressive. The error between the simulation and experiment is less than 0.3%, better than the empirical adjustment required to issue a set of drive current models.
Effective Case Depth and Wear Resistance of Pack Carburized SCM 420 Steel Processed Using Different Concentrations of Natural Shell Waste Powders and Carburizing Duration
Authors: Ramli  , Wu Chung-Chun
Published: February 2022

The efficacy of using coconut shell powder (CSP) and dog conch shell powder (DCSP) as an alternative carburizing media for SCM 420 steel pack carburization was investigated. The effective case depth and wear resistance of quenched specimens prepared using various CSP–DCSP ratios and carburizing times were determined and compared. The effective case depth was measured from the microhardness profile obtained using a Vickers hardness testing machine. A CSP–DCSP ratio of 60%:40% and carburization time of 12 h were found to increase the effective case depth of SCM 420 quenched specimens to 2340 µm. The results clearly showed that the effective case depth increased by increasing carburization time and DCSP concentrations from 0% to 40% as a carburizing media and decreased by further increasing DCSP concentrations to 50%. Moreover, the wear resistance of quenched specimens increased approximately two times as DCSP concentrations were increased from 0% to 40% for a carburization time of 12 h.
Advocacy in Action: Leveraging the Power of Patient Voices to Impact Ovarian Cancer Outcomes in Canada
Authors: Baugh Elisabeth , Tone Alicia , Boghosian Talin , Ross Alison , Crawford Cailey
Published: February 2022

Prior to 1997, ovarian cancer (OC) was a ‘poor target’ for patient advocacy. At that time, there were only three OC researchers in Canada, little information available for women diagnosed, and no community of survivors existed. The Corinne Boyer Fund to advance OC was founded in 1997 (later renamed the National Ovarian Cancer Association (NOCA) and subsequently Ovarian Cancer Canada (OCC)), and a Blueprint for Action was established. NOCA developed training programs for public education, partnered with clinicians and scientists, established a Tissue Banking Network across Canada In 2015, the Ladyballs awareness campaign was launched nationally, giving the community a presence and voice. Strategic planning by the organization put advocacy for research funding as a top priority and, working with patients and researchers across the country, petitioned the government for C$10 million in research funding. In 2019, OCC received the funding. In 2020, the OvCAN project was launched with the aim to improve the outcomes of women diagnosed with OC. In the first three years of OvCAN, a pan-Canadian team of 25 Patient Partners was established, and 41 projects to date on research models, pre-clinical and clinical trials covering a wide spectrum of OC types have been funded.
Visualizing the Invisible—The Needs and Wishes of Childhood Cancer Survivors for Digitally Mediated Emotional Peer Support
Authors: Nilsson Stefan , Segerstad Ylva Hård af , Olsson Maria
Published: February 2022

This study aims to identify the needs and wishes of childhood cancer long-term survivors for digitally mediated emotional peer support. Survivors of childhood cancer (six men, seven women) aged 19–33, participated in semi-structured interviews (November–December 2020). Age of diagnosis ranged from 1 to 13 years. The interviews lasted between 45 and 85 min. A thematic analysis was used to identify three themes for needs: processing long-term complications of cancer treatment, processing psychosocial health and meeting others who share similar experiences; and another three themes reflecting wishes: digital tools for connecting with people who had had similar experiences, different modes of communication and a safe place with varying degrees of anonymity. The findings emphasized the needs and wishes of childhood cancer survivors to meet others who had had similar experiences using a digital tool that offered a secure place, with options for a variety of communication methods and levels of anonymity. Peer support can serve as an important complement to professional psychosocial support.
Quantum Iterative Reconstruction for Low-Dose Ultra-High-Resolution Photon-Counting Detector CT of the Lung
Authors: Sartoretti Thomas , Racine Damien , Mergen Victor , Jungblut Lisa , Monnin Pascal , Flohr Thomas G. , Martini Katharina , Frauenfelder Thomas , Alkadhi Hatem , Euler André
Published: February 2022

The aim of this study was to characterize image quality and to determine the optimal strength levels of a novel iterative reconstruction algorithm (quantum iterative reconstruction, QIR) for low-dose, ultra-high-resolution (UHR) photon-counting detector CT (PCD-CT) of the lung. Images were acquired on a clinical dual-source PCD-CT in the UHR mode and reconstructed with a sharp lung reconstruction kernel at different strength levels of QIR (QIR-1 to QIR-4) and without QIR (QIR-off). Noise power spectrum (NPS) and target transfer function (TTF) were analyzed in a cylindrical phantom. 52 consecutive patients referred for low-dose UHR chest PCD-CT were included (CTDIvol: 1 ± 0.6 mGy). Quantitative image quality analysis was performed computationally which included the calculation of the global noise index (GNI) and the global signal-to-noise ratio index (GSNRI). The mean attenuation of the lung parenchyma was measured. Two readers graded images qualitatively in terms of overall image quality, image sharpness, and subjective image noise using 5-point Likert scales. In the phantom, an increase in the QIR level slightly decreased spatial resolution and considerably decreased noise amplitude without affecting the frequency content. In patients, GNI decreased from QIR-off (202 ± 34 HU) to QIR-4 (106 ± 18 HU) (p < 0.001) by 48%. GSNRI increased from QIR-off (4.4 ± 0.8) to QIR-4 (8.2 ± 1.6) (p < 0.001) by 87%. Attenuation of lung parenchyma was highly comparable among reconstructions (QIR-off: −849 ± 53 HU to QIR-4: −853 ± 52 HU, p < 0.001). Subjective noise was best in QIR-4 (p < 0.001), while QIR-3 was best for sharpness and overall image quality (p < 0.001). Thus, our phantom and patient study indicates that QIR-3 provides the optimal iterative reconstruction level for low-dose, UHR PCD-CT of the lungs.
Radiation Dose and Fluoroscopy Time of Endovascular Coil Embolization in Patients with Carotid Cavernous Fistulas
Authors: Ozpeynirci Yigit , Trumm Christoph Gregor , Stahl Robert , Liebig Thomas , Forbrig Robert
Published: February 2022

Carotid cavernous fistulas (CCFs) are abnormal connections between the cavernous sinus and the internal and/or external carotid artery. Endovascular therapy is the gold standard treatment. In the current retrospective single-center study we report detailed dosimetrics of all patients with CCFs treated by endovascular coil embolization between January 2012 and August 2021. Procedural and dosimetric data were compared between direct and indirect fistulas according to Barrow et al., and different DSA protocol groups. The local diagnostic reference level (DRL) was defined as the 3rd quartile of the dose distribution. In total, thirty patients met the study criteria. The local DRL was 376.2 Gy cm2. The procedural dose area product (DAP) (p = 0.03) and the number of implanted coils (p = 0.02) were significantly lower in direct fistulas. The median values for fluoroscopy time (FT) (p = 0.08) and number of DSA acquisitions (p = 0.84) were not significantly different between groups. There was a significantly positive correlation between DAP and FT (p = 0.003). The application of a dedicated low-dose protocol yielded a 32.6% DAP reduction. In conclusion, this study provides novel DRLs for endovascular CCF treatment using detachable coils. The data presented in this work might be used to establish new specific DRLs.
Understanding Healthcare Professionals’ Perspectives on Point-of-Care Testing
Authors: Teebagy Sean , Wang Ziyue , Dunlap Denise , Saleeba Connor , DiMezza Danielle , Crain JoAnn , Lilly Craig M. , Buchholz Bryan , McManus David D. , Hafer Nathaniel
Published: February 2022

Point-of-care testing (POCT) is an emerging technology that provides crucial assistance in delivering healthcare. The COVID-19 pandemic led to the accelerated importance of POCT technology due to its in-home accessibility. While POCT use and implementation has increased, little research has been published about how healthcare professionals perceive these technologies. The objective of our study was to examine the current perspectives of healthcare professionals towards POCT. We surveyed healthcare professionals to quantify perceptions of POCT usage, adoption, benefits, and concerns between October 2020 and November 2020. Questions regarding POCT perception were assessed on a 5-point Likert Scale. We received a total of 287 survey responses. Of the respondents, 53.7% were male, 66.6% were white, and 30.7% have been in practice for over 20 years. We found that the most supported benefit was POCTs ability to improve patient management (92%) and that the most supported concern was that POCTs lead to over-testing (30%). This study provides a better understanding of healthcare workers’ perspectives on POCT. To improve patient outcomes through the usage of POCT, greater research is needed to assess the needs and concerns of industry and healthcare stakeholders.
A Rare Case of Hepatic Vanishing Bile Duct Syndrome Occurring after Combination Therapy with Nivolumab and Cabozantinib in a Patient with Renal Carcinoma
Authors: Gourari Karim , Catherine Julien , Garaud Soizic , Kerger Joseph , Lepida Antonia , Georgala Aspasia , Lebrun Fabienne , Gomez Galdon Maria , Gil Thierry , Willard-Gallo Karen , Langouo Fontsa Mireille
Published: February 2022

Tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) significantly improve the outcomes of patients with advanced clear cell renal cell carcinoma (ccRCC); however, high-grade toxicities can occur, particularly during combination therapy. Herein, we report a patient with advanced metastatic ccRCC, who developed grade 4 cholestasis during combined therapy with nivolumab and cabozantinib. After the exclusion of common disorders associated with cholestasis and a failure of corticosteroids (CS), a liver biopsy was performed that demonstrated severe ductopenia. Consequently, a diagnosis of vanishing bile duct syndrome related to TKI and ICI administration was made, resulting in CS discontinuation and ursodeoxycholic acid administration. After a 7-month follow-up, liver tests had returned to normal values. Immunological studies revealed that our patient had developed robust T-cells and macrophages infiltrates in his lung metastasis, as well as in skin and liver tissues at the onset of toxicities. At the same time, peripheral blood immunophenotyping revealed significant changes in T-cell subsets, suggesting their potential role in the pathophysiology of the disease.
Identification of Diabetic Retinopathy Using Weighted Fusion Deep Learning Based on Dual-Channel Fundus Scans
Authors: Nneji Grace Ugochi , Cai Jingye , Deng Jianhua , Monday Happy Nkanta , Hossin Md Altab , Nahar Saifun
Published: February 2022

It is a well-known fact that diabetic retinopathy (DR) is one of the most common causes of visual impairment between the ages of 25 and 74 around the globe. Diabetes is caused by persistently high blood glucose levels, which leads to blood vessel aggravations and vision loss. Early diagnosis can minimise the risk of proliferated diabetic retinopathy, which is the advanced level of this disease, and having higher risk of severe impairment. Therefore, it becomes important to classify DR stages. To this effect, this paper presents a weighted fusion deep learning network (WFDLN) to automatically extract features and classify DR stages from fundus scans. The proposed framework aims to treat the issue of low quality and identify retinopathy symptoms in fundus images. Two channels of fundus images, namely, the contrast-limited adaptive histogram equalization (CLAHE) fundus images and the contrast-enhanced canny edge detection (CECED) fundus images are processed by WFDLN. Fundus-related features of CLAHE images are extracted by fine-tuned Inception V3, whereas the features of CECED fundus images are extracted using fine-tuned VGG-16. Both channels’ outputs are merged in a weighted approach, and softmax classification is used to determine the final recognition result. Experimental results show that the proposed network can identify the DR stages with high accuracy. The proposed method tested on the Messidor dataset reports an accuracy level of 98.5%, sensitivity of 98.9%, and specificity of 98.0%, whereas on the Kaggle dataset, the proposed model reports an accuracy level of 98.0%, sensitivity of 98.7%, and specificity of 97.8%. Compared with other models, our proposed network achieves comparable performance.
Factors Associated with Delirium in COVID-19 Patients and Their Outcome: A Single-Center Cohort Study
Authors: Di Giorgio Annabella , Mirijello Antonio , De Gennaro Clara , Fontana Andrea , Alboini Paolo Emilio , Florio Lucia , Inchingolo Vincenzo , Zarrelli Michele , Miscio Giuseppe , Raggi Pamela , Marciano Carmen , Antonioni Annibale , De Cosmo Salvatore , Aucella Filippo , Greco Antonio , Carella Massimo , Copetti Massimiliano , Leone Maurizio A.
Published: February 2022

Background: A significant proportion of patients with coronavirus disease 2019 (COVID-19) suffer from delirium during hospitalization. This single-center observational study investigates the occurrence of delirium, the associated risk factors and its impact on in-hospital mortality in an Italian cohort of COVID 19 inpatients. Methods: Data were collected in the COVID units of a general medical hospital in the South of Italy. Socio-demographic, clinical and pharmacological features were collected. Diagnosis of delirium was based on a two-step approach according to 4AT criteria and DSM5 criteria. Outcomes were: dates of hospital discharge, Intensive Care Unit (ICU) admission, or death, whichever came first. Univariable and multivariable proportional hazards Cox regression models were estimated, and risks were reported as hazard ratios (HR) along with their 95% confidence intervals (95% CI). Results: A total of 47/214 patients (22%) were diagnosed with delirium (21 hypoactive, 15 hyperactive, and 11 mixed). In the multivariable model, four independent variables were independently associated with the presence of delirium: dementia, followed by age at admission, C-reactive protein (CRP), and Glasgow Coma Scale. In turn, delirium was the strongest independent predictor of death/admission to ICU (composite outcome), followed by Charlson Index (not including dementia), CRP, and neutrophil-to-lymphocyte ratio. The probability of reaching the composite outcome was higher for patients with the hypoactive subtype than for those with the hyperactive subtype. Conclusions: Delirium was the strongest predictor of poor outcome in COVID-19 patients, especially in the hypoactive subtype. Several clinical features and inflammatory markers were associated with the increased risk of its occurrence. The early recognition of these factors may help clinicians to select patients who would benefit from both non-pharmacological and pharmacological interventions in order to prevent delirium, and in turn, reduce the risk of admission to ICU or death.