bluuebunny/crossref_metadata_2025 huggingface dataset:
EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports)
Authors: Kovrigina Alla Mikhailovna
Published: October 2018

In recent years increasing attention focuses on the concept of EBV-positive lymphoproliferative diseases related to primary or secondary immunodeficiency resulting from immunosuppressive therapy and persistent infections. Due to the progress of treatment methods in oncohematology and oncology this pathology also occurs as a delayed event when new surgical and therapeutic approaches are applied. The paper presents proof for the pathogenetic significance of Epstein-Barr virus (EBV) in the pathology under consideration with its various clinical manifestations and describes the evolution of knowledge on posttransplant lymphoproliferative disorders with their morphological classification underlying EBV+ lymphoproliferative diseases. The WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues revised in 2017 includes new forms of EBV+ lymphoproliferative diseases (mucocutaneous ulcer, T- and NK-cell childhood lymphoproliferative disorders including cutaneous and systemic forms of chronic active EBV infection) and EBV+ large B-cell lymphomas (unspecified and fibrin-associated diffuse large B-cell lymphomas). The paper summarizes major characteristics of these diseases and exemplifies them by the author’s own experience.
Expression of the BCR-ABL1 Gene in Patients with Chronic Myeloproliferative Diseases with Signs of Progression
Authors: Kesaeva L.A. , Misyurina E.N. , Mar'in D.S. , Zhelnova E.I. , Bulanov A.Yu. , Misyurina A.E. , Krutov A.A. , Soldatova I.N. , Zborovskii S.S. , Misyurin Andrei Vital'evich , Tikhonova V.V. , Finashutina Yu.P. , Solopova O.N. , Lyzhko N.A. , Bespalova A.E. , Kasatkina N.N. , Ponomarev A.V. , Lysenko M.A. , Misyurin Andrei Vital'evich
Published: October 2018

Background. The V617F mutation of JAK2 is known to manifest in Ph-negative chronic myeloproliferative diseases (cMPD), such as polycythemia vera, thrombo-cythemia, and myelofibrosis. These diseases not infrequently advance into more aggressive forms up to acute leukemia. As the progression mechanism is still unknown, its study retains a high priority. JAK2 carrying the V617F mutation is believed to cause constant activation of V(D) J recombinase in myeloid tumor cells in cMPD patients. Aberrant activation of V(D)J recombinase in tumor cells in cMPD patients can lead to t(9;22)(q34;q11) chromosomal rearrangement. Aim. To study the expression of BCR-ABL1 resulting from translocation t(9;22)(q34;q11) in cMPD patients at the progression stage in order to test the suggested hypothesis. Materials & Methods. The BCR-ABL1 expression was assessed in peripheral blood granulocytes in cMPD patients by real-time PCR. The JAK2 V617F mutation was identified by quantitative allele-specific PCR. The JAK2 exon 12 mutations were determined using Sanger direct sequencing of PCR products. Results. The BCR-ABL1 expression was discovered in 29 % of patients with cMPD progression. The BCR-ABL1 expression in these patients correlated with hepatosplenomegaly and hyperleukocytosis.
Correlation of CD34+ Hematopoietic Stem Cells and CFU in Peripheral Blood Apheresis Products in Patients with Malignant Lymphoproliferative Diseases Before and After Cryopreservation Prior to auto-HSCT
Authors: Balashova Alentina Andreevna , Rugal' V.I. , Bessmeltsev S.S. , Gritsaev S.V. , Semenova N.Yu. , Voloshin S.V. , Chubukina Zh.V. , Shmidt A.V. , Garifullin A.D. , Zapreeva I.M. , Kuzyaeva A.A. , Kostroma I.I. , Kuvshinov A.Yu. , Chechetkin A.V.
Published: October 2018

Aim. To establish correlation between CD34+ autologous hematopoietic stem cell (HSC) count and colony-forming units (CFU) in the same peripheral blood apheresis product samples before and after cryopreservation in multiple myeloma and lymphoma patients, and to assess clinical value of these parameters. Materials & Methods. Cell samples of peripheral blood cyta-pheresis product and cell cultures were studied before and after cryopreservation in 32 multiple myeloma and 25 lymphoma patients who underwent autologous HSC transplantation. The material was analyzed using culture technique and flow cytometry. Results. The paper provides information on the relationship between CD34+ HSC count obtained by flow cytometry, and CFU in cell culture obtained by cytapheresis of the same peripheral blood samples. A direct correlation was confirmed between CD34+ count and all the CFUs before and after cryopreservation in lymphoma patients. Correlation between CD34+ count and granulocyte-macrophage CFUs was revealed in multiple myeloma and lymphoma patients before cryopreservation. Conclusion. The parameter of colony-forming capacity used for the assessment of the functional HSC was shown to be equally reliable criterion for condition evaluation of autotransplant proliferative pool than CD34+ cells. Both methods should be applied for qualitative and quantitative evaluation of an autotransplant for multiple myeloma and lymphoma patients.
Cardiovascular Toxicity of Tyrosine Kinase Inhibitors in Patients with Chronic Myeloid Leukemia
Authors: Davydkin I.L. , Naumova Kseniya Viktorovna , Osadchuk A.M. , Zolotovskaya I.A. , Danilova O.E. , Stepanova T.Yu. , Tereshina O.V. , Limareva L.V. , Shpigel' A.S. , Kuz'mina T.P.
Published: October 2018

In the present review the cardiovascular complications in patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitors (TKI) are discussed. It covers current views on pathogenesis of TKI cardiovascular toxicity. The pathophysiology of cardiovascular diseases (CVD) is considered as a part of the so-called pathophysiological continuum, i.e. a complex of processes developing at the molecular and cellular levels before clinical symptoms of the above diseases occur. Cardiovascular toxicity of certain TKIs can contribute to progression of pathophysiological processes in CML patients. The study of mechanisms underlying cardiovascular complications of TKI-based therapy is essential for evaluating the risks of their development in each patient. Identification of CVD predictors during TKI-based therapy can allow to elaborate a scheme for cardiovascular monitoring and safe patient management under consideration of individual risks and to avoid severe life-threatening complications.
The raw material potential of the Czech Republic
Authors: Korandová Beáta , Straková Alena , Beránek Jiří , Vrublová Dana
Published: October 2018

This article summarizes the information on raw materials in the Czech Republic. Although mining was significantly reduced not long ago, there are still rich deposits of ores, non-metallic raw materials, as well as energetic and construction ones. Many of them are potentially utilizable in future, especially those which are economically favorable, and their mining is not in any conflict with environmental interests. Deposits are distributed irregularly, and their raw materials are different in both the Bohemian Massif and Western Carpathians. In order to be complete, the text also comprises deposits, which are restricted by environmental limits or their mining promises a low-cost effectiveness. The article is amended with actual statistical data.
Nanotechnology in Enzyme Immobilization: An Overview on Enzyme Immobilization with Nanoparticle Matrix
Authors: Singh Kushagri , Mishra Abha , Sharma Deepankar , Singh Kavita
Published: October 2018

Engineering of biocatalysts with the help of immobilization techniques is a worthy approach
for the advancement of enzyme function and stability and is finer to the other chemical as
well as biological methods. These biocatalysts encapsulation methods actually use very gentle
method conditions that hardly affect biocatalysts internal specific biocatalytic activity and this leads
to its internment without losing its freedom but restrict the movements related to unfolding. Additionally,
enzyme encapsulation somehow imitates their mode of normal incidence within the cells
and it also provides secured surroundings for enzymes to the operating parameter changes. According
to these advantages, enzyme encapsulation finds enhanced applications in a wide variety of fields
such as medicine and sustained or continuous release delivery systems, biosensing, clinic diagnostic,
biocatalysts in the manufacture of high-value yield correlated to pharmaceuticals especially in cancer
cure, fragrances as well as flavors. This review mainly focuses on the current status of enzyme immobilization
using nanocarriers, nanoparticles or polymeric matrix materials, which aim to summarize
the latest research on the natural polymer, chitosan based nanoparticles in various enzyme immobilizations.
Foliar micromorphological character studies on Trichosanthes L. (Cucurbitaceae) from Terai & Duars, West Bengal, India.
Authors: Chowdhury Roshni , Chowdhury Anurag , Chowdhury Monoranjan
Published: October 2018

Trichosanthes is one of the most economically important genera of the family Cucurbitaceae. Studies on trichome micro-morphology and stomata were investigated for six species of Trichosanthes. All species has been recorded from the Terai and Duars of West Bengal. Range of variability in Trichosanthes species are quite variable, trichomes types including uni-multiseriate, macro-microform, conical, candelabra, capitated, glandular and non- glandular. Stomatal character shows variability (Paracytic, Actinocytic, Anomocytic and Diacytic). Trichomes and stomatal characters are utilised for phenetic studies which found to be important taxonomic tools to solve any disputes at least at or below species level.
Pola spektral tanaman tebu (saccharum officinarum l.) Menggunakan spektrofotometer dan citra penginderaan jauh di kabupaten bantul
Authors: Hardjo Karen Slamet , Indrawati Like
Published: October 2018

Sugar becomes one of the commodities targeted to achieve Indonesia national food security. Sugar is produced from sugarcane (Saccharum officinarum L.), extensive plantations require effective and efficient handling and low cost. Remote sensing is a technology that is considered appropriate to answer those needs, through remote sensing image can be analyzed to the physical condition of sugar cane plant based on the spectral response recorded on the image. The spectral response captured by the sensor is expected to help analyze this plant in relation to plant growth, plant health, as well as the production of sugar yields in sugarcane. The lack of spectral pattern research, especially the in situ spectral pattern that is used as a reference for remote sensing data analysis, makes this research important to do. Bantul Regency is a region that has a large agricultural area, including sugar cane plantation. The method used in this research is digital data processing on remote sensing image to be analyzed spectral pattern especially in sugarcane which then compared with data of spectral pattern of sugar cane which is measured directly in the field using spectrophotometer. Spectral patterns obtained from two sources are then analyzed to determine the agility of sugarcane. The result of this research is give description about spectral pattern characteristic or reflectance pattern in sugar cane plant so it can be used for mapping of sugar cane plantation. The Sugar cane Plant reflected curve from the field measurements by spectrophotometer is noticeably smoother and has more wavelengths than the reflected curves of the Landsat 8 OLI Image. The distribution of sugar cane plant based on the spectral reflectance pattern of the object of field measurement is more relevant than the distribution of sugarcane based on the spectral reflection pattern of the object from Landsat 8 OLI Image. The classification of the field measurement spectral library and the Landsat 8 OLI Image shows that the spectral library of field measurements is better to serve as the basis for spectral-based mapping than the sampled spectral libraries in Landsat 8 OLI Image.
MU-SYNTHESIS BASED ACTIVE ROBUST VIBRATION CONTROL OF AN MRI INLET
Authors: Oveisi Atta , Nestorović Tamara
Published: October 2018

In this paper, a robust control technique based on μ-synthesis is employed in order to investigate the vibration control of a funnel-shaped structure that is used as the inlet of a magnetic resonance imaging (MRI) device. MRI devices are widely subjected to the vibration of the magnetic gradient coil which then propagates to acoustic noise and leads to a series of clinical and mechanical problems. In order to address this issue and as a part of noise cancellation study in MRI devices, distributed piezo-transducers are bounded on the top surface of the funnel as functional sensor/actuator modules. Then, a reduced order linear time-invariant (LTI) model of the piezolaminated structure in the state-space representation is estimated by means of a predictive error minimization (PEM) algorithm as a subspace identification method based on the trust-region-reflective technique. The reduced order model is expanded by the introduction of appropriate frequency-dependent weighting functions that address the unmodeled dynamics and the augmented multiplicative modeling uncertainties of the system. Then, the standard D-K iteration algorithm as an output-feedback control method is used based on the nominal model with the subordinate uncertainty elements from the previous step. Finally, the proposed control system implemented experimentally on the real structure is to evaluate the robust vibration attenuation performance of the closed-loop system.
BENDING VIBRATION AND STABILITY OF A MULTIPLE-NANOBEAM SYSTEM INFLUENCED BY TEMPERATURE CHANGE
Authors: Karličić Danilo , Ožvat Sanja , Cajić Milan , Kozić Predrag , Pavlović Ratko
Published: October 2018

In this study, we analyzed the bending vibration and stability of a multiple-nanobeam system (MNBS) coupled in elastic medium and influenced by temperature change and compressive axial load. The MNBS is modeled as the system consisting of a set of m identical and simply supported nanobeams mutually connected by Winkler’s type elastic layers. According to the Euler - Bernoulli beam and nonlocal thermo-elasticity theory, the system of m coupled partial differential equations is derived and solved by means of the method of separation of variables as well as the trigonometric one. Analytical solutions for natural frequencies and critical buckling loads of elastic MNBS are obtained. The effects of nonlocal parameter, temperature change and the number of nanobeams on the natural frequencies and the buckling loads are investigated through numerical examples. Thus, this work can represent a starting point to examine dynamical behavior and design of complex nanobeam structures, nanocomposites and nanodevices under the influence of various physical fields.
A STUDY OF THIN FILM LUBRICATION AT NANOSCALE FOR A FERROFLUID BASED INFINITELY LONG ROUGH POROUS SLIDER BEARING
Authors: Patel Jimit R. , Deheri Gunamani
Published: October 2018

The study aims at analyzing the performance of a ferrofluid-based infinitely long rough porous slider bearing which makes use of thin film lubrication at nanoscale. The stochastic model of Christensen and Tonder has been employed to analyze the effect of surface roughness while the Neuringer-Rosensweig’s model has been adopted to study the magnetization effect. The pressure distribution in the bearing system has been obtained by solving the associated stochastically averaged Reynolds type equation. The results indicate that although the transverse roughness is supposed to affect the bearing system adversely, the situation remains fairly better in the case of thin film lubrication at nanoscale. In fact, the consideration of thin film lubrication at nanoscale results in an all round improved performance, even for lower strength of the magnetic intensity. However, the couple stress adds a little more to this positive effect.
RELIABLE ROBUST CONTROLLER FOR HALF-CAR ACTIVE SUSPENSION SYSTEMS BASED ON HUMAN-BODY DYNAMICS
Authors: Gudarzi Mohammad
Published: October 2018

The paper investigates a non-fragile robust control strategy for a half-car active suspension system considering human-body dynamics. A 4-DoF uncertain vibration model of the driver’s body is combined with the car’s model in order to make the controller design procedure more accurate. The desired controller is obtained by solving a linear matrix inequality formulation. Then the performance of the active suspension system with the designed controller is compared to the passive one in both frequency and time domain simulations. Finally, the effect of the controller gain variations on the closed-loop system performance is investigated numerically.
Populismo y derechos ciudadanos: anotaciones sobre un vínculo errante.
Authors: Barros Mercedes , Morales Virginia
Published: October 2018

En el presente artículo se aborda la relación entre populismo y derechos ciudadanos desde una perspectiva histórica y política, atendiendo a ciertos aspectos atribuibles al populismo en tanto fenómeno político específico y enfocando el análisis en una experiencia histórica determinada de los así llamados populismos clásicos. Puesto que de manera reiterada se ha señalado que los regímenes populistas suponen una convivencia conflictiva en el ejercicio efectivo de los derechos y libertades individuales, el objetivo del artículo se encamina a contribuir al esclarecimiento de esta tensión. En particular, se centra en la experiencia política del primer peronismo, dirigiendo la mirada sobre las implicaciones de este vínculo en la base de la sociedad. Para tal propósito, se recuperan ciertas matrices textuales heterodoxas, a través de las cuales se busca dilucidar la experiencia subjetiva que se forjó en torno al ejercicio de los derechos ciudadanos con el telón de fondo del discurso peronista.Abstract: This paper addresses the relationship between populism and civil rights from a political and historical perspective, paying attention to certain theoretical approaches that can be attributed to populism understood as a specific political phenomenon and focusing analysis on a certain historical experience of so called classical populisms. As time and time again it has been suggested that populism imply a conflictive coexistence between the effective exercise of individual rights and its freedoms. The aim of this paper is to feed the clarification of this tension. It focuses on the political experience of first peronismo. The paper aims to contribute to the clarification of the tension that characterizes this link, particularly focusing on its implications at the base of society. For this purpose, we recover certain heterodox textual matrices, in which we hope to elucidate the subjective experience that was forged around the exercise of civil rights against the backdrop of Peronist discourse.
Deterioration effects of coupled blisk blades
Authors: Kellersmann Andreas , Reitz Gerald , Friedrichs Jens
Published: October 2018

Performance degradation due to wear of high pressure compressors (HPC) is a major concern in aero-engine operation and maintenance. Among other effects especially erosion of airfoils leads to changed aerodynamic behavior and therefore to deterioration. These affects engine performance parameter like thrust specific fuel consumption (TSFC) and exhaust gas temperature (EGT). Reaching EGT-limit, the engine typically has to be overhauled during a shop visit to restore safety standards and performance. During state of the art shop visits, engines are repaired based on EGT-specifications. To further enhance the maintenance, tailored repairs for each jet engine based on engine history and operation conditions are necessary to take TSFC into account. To ensure such an effective maintenance, the aerodynamic behavior of deteriorated and repaired airfoils is the key factors. Therefore, geometric properties with high influence on aerodynamic performance have to be known. For blisks (BLade-Integrated-diSK) the approach of tailored maintenance will be even more complicated because the airfoil arrangement cannot be changed or individual airfoils cannot be replaced. Thus, the effects of coupled misshaped airfoils have a high significance. This study will present a Design of Experiments (DoE) for circumferential coupled HPC-airfoils to identify the geometric properties which lead to a reduction of performance. To focus on geometric variations, quasi3D (Q3D) simulations are taken out. Based on a sensitivity analysis, the thickness related parameters, the stagger angle as well as the max. profile camber thickness are identified as the most important parameters which are influencing adjacent airfoils and reduce the aerodynamic performance.
VITAMIN STATUS OF LAW ENFORCEMENT OFFICERSUNDER THE INFLUENCE OF COMBAT STRESS
Authors: Potolitsyna N. N. , Boyko E. R.
Published: October 2018

Law enforcement officers with different levels of combat stress (men, residents of the Komi Republic, n=33, 35,0 (32,0– 39,0) years old) were examined before (November) and after (March) trips to the combat zone. The control group included agents of the Ministry of emergency situations with a low level of stress (men, residents of the Komi Republic, 32,0 (30,0–35,0) years old). In total, law enforcement officers were shown to have a wide prevalence of vitamin deficiency: about 50% of persons had hypovitaminosis for vitamins A, E, about 35% — for vitamins B1, B2 and 24% — for vitamin C. A parallel study of the control group and law enforcement officers in November showed that initially there were more persons with reduced vitamin status in law enforcement officers, especially in the level of vitamins B1 and E. In March, after the arrival of law enforcement officers from the combat zone, they found a significant decrease in the percentage of persons with hypovitaminosis for vitamins A, E, C and an increase vitamin B1 deficiency. Changes vitamin status in the control group from November to March were not so significant.
Pengaruh Metode Resitasi Terhadap Hasil Belajar Biologi Siswa Kelas XI Sekolah Menengah Atas Negeri 1 Tanjung Jabung Timur
Authors: Susanti Try , Sari Novita , Hidayat Hidayat
Published: October 2018

Pemberian tugas dan pekerjaan rumah kepada siswa adalah salah satu metode guru dalam proses pembelajaran di Sekolah Menengah Atas Negeri 1 Tanjung Jabung Timur. Tugas dan pekerjaan rumah tersebut diberikan agar siswa belajar secara mandiri. Tetapi tugas yang diberikan hanya sekedar tugas, tidak ada tuntutan dari guru agar siswa dapat mempertanggung jawabkan tugas yang dikerjakannya. Hal ini menyebabkan siswa tidak termotivasi untuk memahami materi yang terkandung dalam tugas tersebut sehingga mempengaruhi hasil belajar. Untuk itu perlu adanya suatu metode pembelajaran yang dapat mengatasi permasalahan tersebut. Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh metode resitasi terhadap hasil belajar. Penelitian ini menggunakan pendekatan kuantitatif yang bersifat eksperimen semu dengan desain Postest Only Control Design. Dengan teknik pengambilan sampel secara undian, dan didapat kelas XI IPA 2 (eksperimen) dan kelas XI IPA 3 (kontrol). Dari analisis data uji tes “t” didapat hasil taraf signifikansi ttabel 5% = 1,996, t0 =3,05 didapat hasil thitung  ≥ ttabel yang berarti bahwa adanya selisih signifikansi mean. Pada uji Effect Size untuk mengetahui pengaruh metode resitasi terhadap hasil belajar didapat hasil dengan persentasi 76% dalam kategori berpengaruh sedang. Dan hasil dari perhitungan korelasi phi dengan taraf signifikansi 5% = 0,223 didapat hasil rhitung ≥ rtabel  0,265 ≥ 0,223 artinya Ha diterima. Dari analisis data di atas dapat disimpulkan bahwa terbukti terdapat pengaruh yang signifikan antara penggunaan metode resitasi terhadap hasil belajar biologi.
Pengembangan Bahan Ajar Praktikum dan Instrumen Penilaian Berbasis Keterampilan Proses Sains pada Mata Kuliah Mikologi Program Studi Pendidikan Biologi Universitas Jambi
Authors: Harlis Harlis , Budiarti Retni S
Published: October 2018

Upaya meningkatkan pemahaman mahasiswa terhadap pembelajaran Mikologi, maka dilakukan praktikum sebagai penunjang dalam pengembangan Keterampilan Proses Sains peserta didik. Penerapan Keterampilan Proses Sains sekaligus pengembangan sikap ilmiah yang mendukung proses pengetahuan dalam diri peserta didik dalam hal ini mahasiswa sangat dimungkinkan dalam kegiatan praktikum. Tujuan pengembangah ini adalah untuk menghasilkan Bahan Ajar Praktikum dan Instrumen Penilaian Berbasis Keterampilan Proses Sains Pada Mata Kuliah Mikologi Program Studi Pendidikan Biologi Universitas Jambi yang valid, praktis dan efisien. Penelitian ini adalah penelitian pengembangan (research and development), dengan model pengembangan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Hasil penelitian ini didapat uji validitas bahan ajar praktikum rata-rata validitas 3,15 (kategori valid), validitas instrumen diperoleh rata-rata  nilai dari validator 3,12 (kategori valid). Uji praktikalitas dari keterlaksanaan praktikum menunjukkan rata-rata 3,56 (kategori praktis), dan dari angket respon mahasiswa dengan rata-rata 3,51 (kategori praktis). Hasil uji efektivitas diperoleh rata-rata aktivitas siswa dengan rata-rata nilai 81,65 (kategori sangat tinggi). Dengan demikian dapat disimpulkan bahan ajar praktikum dan instrumen penilaian berbasis keterampilan proses sains yang dikembangkan berada pada kategori valid, praktis dan sangat efektif.
Pengaruh Penerapan Strategi Pembelajaran Rotating Trio Exchange Terhadap Hasil Belajar Mata Kuliah Dasar-Dasar dan Proses Pembelajaran Biologi
Authors: Sadikin Ali
Published: October 2018

Salah satu strategi pembelajaran biologi adalah strategi pembelajaran Rotating Trio Exchange (RTE). Strategi ini merupakan rencana kegiatan pembelajaran untuk mengaktifkan mahasiswa. Strategi ini merupakan cara peserta didik untuk mendiskusikan permasalahan dengan beranggotakan tiga orang. Pengaruh penerapan strategi pembelajaran Rotating Trio Exchange terhadap hasil belajar mahasiswa pada mata kuliah Dasar-dasar dan proses pembelajaran biologi aspek kognitif, aspek afektif dan aspek psikomotor. Jenis penelitian ini adalah penelitian True Experimental Design. Peneliti ini telah dilakukan pada semester Ganjil 2017/2018. Sedangkan sampel yang digunakan kelas Reguler A Semester 3 sebagai kelas eksperimen dan kelas reguler B Semester 3 sebagai kelas kontrol.  Instrumen dalam penelitian ini adalah tes objektif dan lembar pengamatan. Hasil penelitian menunjukkan pada aspek kogitif adalah thitung =2,395 dan ttabel = 1,674. Aspek afektif  adalah thitung = 2,733 dan  ttabel = 1,674. Pada aspek Psikomotor thitung = 2,520 dan ttabel = 1,674. Berdasarkan hasil penelitian pada aspek kognitif penggunaan strategi pembelajaran Rotating Trio Exchange dapat meningkatkan hasil belajar mahasiswa pada mata kuliah Dasar-Dasar dan Proses Pembelajaran Biologi. Pada aspek afektif perlakuan yang berbeda pada waktu proses pembelajaran sehingga terdapat perbedaan hasil belajar yang berbeda pula. Sedangkan pada aspek psikomotor terdapat keaktifan serta keterampilan mahasiswa dikelas. Dari hasil penelitian dapat disimpulkan bahwa penggunaan strategi pembelajaran Rotating Trio Exchange (RTE) berpengaruh terhadap hasil belajar mahasiswa pada mata kuliah DPPB. Diharapkan strategi pembelajaran RTE dapat digunakan dalam Pembelajaran mata kuliah lain.
Enfermedad de Menétrier en niños: reporte de dos casos
Authors: Wilches-Luna Alejandra , Osorio Germán , Oviedo Natalia , Higuita Julián , Cardona Andrea Catalina
Published: October 2018

Se presentan 2 casos de enfermedad de Ménétrier (EM) remitidos a nuestra institución por síndrome edematoso. Esta enfermedad de poca prevalencia es una gastropatía hipertrófica perdedora de proteínas que en la mayoría de los casos es de causa desconocida, aunque se ha asociado con procesos infecciosos. Se caracteriza por edema, hipoproteinemia, hipoalbuminemia y, en la infancia, es de carácter benigno y autolimitado.
Tumor neuroendocrino primario de intestino delgado, con sangrado digestivo oscuro manifiesto: Un Reporte de Caso.
Authors: Mosquera-Klinger Gabriel Alonso , Hernández A Juan Esteban
Published: October 2018

Presentamos el caso de un paciente joven, sin historia de enfermedad. Con sangrado manifiesto por melenas, hematoquezia, y severa anemización. Estudios endoscópicos iniciales normales. En video cápsula endoscópica (VCE) se evidencia lesión subepitelial ulcerada en yeyuno. Alta sospecha de GIST vs tumor neuroendocrino, por lo que se marca en enteroscopia. Se hacen estudios de extensión que son normales, por lo que se programa a resección local por laparoscopia.
Tratamiento de la Hepatitis C crónica en pacientes de edad avanzada con Enfermedad Renal Crónica: Revisión estructurada
Authors: Ledezma Morales Mónica , Amariles Muñoz Pedro
Published: October 2018

La Hepatitis C (HC) es un problema de salud pública a nivel mundial, con alta prevalencia en pacientes mayores de 50 años. Esta población es más propensa a sufrir Enfermedad Renal Crónica (ERC), tanto por la infección por el Virus de la HC, como por su edad y múltiples comorbilidades. Aquellos con ERC, estadios 4 o 5, pueden ser una población de mayor complejidad farmacológica, por su variabilidad farmacológica y por la limitada información de seguridad y eficacia de los nuevos antivirales en ese grupo de pacientes.  Objetivo: sistematizar información de dosificación de medicamentos para la HC crónica, a partir de estudios o reportes que incluyeran pacientes de edad avanzada con ERC.Material y método: revisión estructurada en PubMed/Medline con los términos: "Hepatitis C", “Aged", "Renal Insufficiency"; artículos publicados entre 01/08/2012 y 01/08/2017, en inglés o español, estudios realizados en humanos, con acceso a texto completo.Resultados: Se identificaron 83 artículos, de los cuales se seleccionaron 14; además se incluyeron 4 manuscritos referenciados en las publicaciones revisadas. Se estructuró un cuadro con información de dosificación de antivirales para el tratamiento de la HC en pacientes de edad avanzada con ERC.Conclusiones: Se presenta información sobre el ajuste de dosis de los medicamentos antivirales utilizados para la HC crónica, en pacientes de edad avanzada y ERC, que podría favorecer los procesos de prescripción y seguimiento, para contribuir a la efectividad y seguridad de dichos fármacos en esta población.
Formation of the honeycomb-like MgO/Mg(OH)2 structures with controlled shape and size of holes by molten salt electrolysis
Authors: Vukicevic Natasa , Cvetkovic Vesna , Nikolic Nebojsa , Brankovic Goran , Barudzija Tanja , Jovicevic Jovan
Published: October 2018

Synthesis of the honeycomb-like MgO/Mg(OH)2 structures, with controlled shape and size of holes, by the electrolysis from magnesium nitrate hexahydrate melt onto glassy carbon is presented. The honeycomb-like structures were made up of holes, formed from detached hydrogen bubbles, surrounded by walls, built up of thin intertwined needles. For the first time, it was shown that the honeycomb-like structures can be obtained by molten salt electrolysis and not exclusively by electrolysis from aqueous electrolytes. Analogies with the processes of the honeycomb-like metal structures formation from aqueous electrolytes are presented and discussed. Rules established for the formation of these structures from aqueous electrolytes, such as the increase of number of holes, the decrease of holes size and coalescence of neighbouring hydrogen bubbles observed with increasing cathodic potential, appeared to be valid for the electrolysis of the molten salt used.
CURRÍCULO E CONHECIMENTO ESCOLAR COMO MEDIADORES EPISTEMOLÓGICOS DO PROJETO DE NAÇÃO E DE CIDADANIA.
Authors: ALMEIDA Fernando José de , Silva Maria da Graça Moreira da
Published: October 2018

Este artigo tece o diálogo entre currículo e conhecimento escolar, frente às crescentes demandas e responsabilidades educacionais, não tipicamente escolares, originadas nas últimas décadas do século XX.  Reconhece e nomeia as tensões inerentes ao contexto educacional contemporâneo e suas variáveis e, para fomentar o diálogo, revisita brevemente as raízes da educação integral escolanovistas, bem como os marcos da construção das políticas educacionais brasileiras culminando com a Base Curricular Comum Curricular (BNCC). Versa sobre a centralidade epistemológica do conhecimento escolar que cabe à finalidade da escola e à sua coerente competência como agência social de formação do conhecimento de gerações. O artigo contribui com o diálogo apontando caminhos para a construção de um desenho curricular que aproxime o conhecimento social com o conhecimento cultural, linguístico, científico e histórico, para consolidar um trabalho escolar de formação de competências cognitivas dos estudantes na participação da vida e de um digno viver coletivo. Conclui, provisória e preocupadamente, que as variáveis culturais e políticas que marcaram o cenário onde debate curricular ocorreu, se organizam em torno da carência que o pensamento estratégico sobre currículo acontece, sobre a pouca clareza do que seja o conhecimento escolar como espaço epistemológico de desenvolvimento do pensamento de um país, e de uma indefinição da função do estado enquanto instituição social que cuida da educação como direito de todos e como bem público.
AUTONOMIA, COMUNICAÇÃO ONLINE E COLABORAÇÃO NOS ESPAÇOS VIRTUAIS: UMA ANÁLISE SOBRE A PERCEPÇÃO DOS ESTUDANTES
Authors: Lima Wannise De Santana
Published: October 2018

O crescente uso das plataformas Learning Management System (LMS) como apoio às aulas presenciais no ensino superior modifica o contexto no qual os processos de aprendizagem ocorrem, as relações entre professores e estudantes e as atividades que estes realizam. Neste estudo, analisou-se a relação entre as percepções dos estudantes sobre a plataforma e os seus níveis de satisfação com o uso das LMS, considerando a sua contribuição para o desenvolvimento de competências para a comunicação online, para o trabalho colaborativo e para a autonomia. Com uma abordagem quantitativa, o estudo integra a análise estatística das respostas a um questionário online aplicado aos 3740 estudantes de Licenciatura e Mestrado Integrado da Universidade de Lisboa que usaram as plataformas LMS como apoio ao ensino presencial no ano letivo 2012/13. As 604 respostas analisadas permitem conhecer a opinião dos estudantes sobre o uso destes sistemas. Os resultados revelaram a existência de correlação significativa entre a percepção dos estudantes e a sua satisfação com as plataformas. Os estudantes reconhecem que o uso da plataforma torna-os mais autônomos para o estudo e que aprenderam mais nas disciplinas onde os docentes tiraram proveito destes sistemas online.
Maria Sibylla Merian: uma mulher transformando ciência em arte
Authors: Machado Elaine Ferreira , Miquelin Awdry Feisser
Published: October 2018

ResumoEste artigo tem o objetivo de apresentar a vida e, principalmente, a obra de uma artista-cientista do século XVII, Maria Sibylla Merian (1647-1717), bem como o potencial da sua produção para as relações de ensino-aprendizagem em Ciências. Para isso, foram feitas pesquisas bibliográficas tanto de fontes primárias como fontes secundárias relativas à biografia da autora. Considera-se sua obra e, principalmente, seus estudos sobre os seres vivos, com seus respectivos ciclos de vida, uma produção inédita ao período histórico em que viveu. Nesse período, acreditava-se na geração espontânea e, no entanto, ela conseguiu observar, descrever e pintar em tela os seres vivos e seus ciclos reprodutivos. Assim, as inúmeras telas por ela produzidas e publicadas em seus livros constituem material riquíssimo para a exploração e transposição no ensino. Palavras-chave: História da Ciência; Maria Sibylla Merian; Ensino.AbstractThis article aims to present the life and mainly the work of a seventeenth-century artist-scientist, Maria Sibylla Merian (1647-1717), as well as the potential of its production for teaching-learning relations in Sciences. For this, bibliographical research was done both from primary sources and secondary sources related to the biography of the author. Her work, and especially her studies of living beings with their respective life cycles, is an unprecedented production of the historical period in which she lived, where she believed in spontaneous generation, and yet she was able to observe, describe and paint on canvas the living beings and their reproductive cycles. The innumerable canvases she produces and published in her books are very rich material for exploration and transposition in teaching.Keywords: History of Science; Maria Sibylla Merian; Teaching.
RESPONS PERTUMBUHAN SEEDLING MANGGIS (Garcinia mangostana L.) TERHADAP PENAMBAHAN N6-BENZYLADENIN DAN INDOLE BUTYRIC ACID
Authors: Zakaria Muhammad Rizki , Rugayah Rugayah , Karyanto Agus
Published: October 2018

Manggis (Garcinia mangostana L.) merupakan salah satu jenis tanaman pohon yang tumbuh di daerah tropis dan memiliki nilai manfaat tinggi. Salah satu upaya penyediaan bibit yang dapat dilakukan dalam meningkatkan jumlah dan kualitas bibit manggis adalah dengan pemberian zat pengatur tumbuh benziladenin (BA) dan indole butyric acid (IBA). Penelitian ini bertujuan untuk menentukan konsentrasi benziladenin terbaik untuk pertumbuhan seedling manggis, pertumbuhan seedling manggis yang paling baik antara yang diaplikasikan IBA 100 ppm dengan yang tanpa diaplikasikan IBA, dan konsentrasi BA terbaik dalam meningkatkan pertumbuhan seedling manggis pada masing-masing pemberian IBA. Penelitian ini dilaksanakan di rumah kaca Hortikultura Fakultas Pertanian Universitas Lampung dari bulan Desember 2015 sampai Maret 2016 dengan menggunakan rancangan acak kelompok (RAK) yang disusun secara faktorial (3 x 2) dengan tiga ulangan. Faktor pertama yaitu berbagai konsentrasi BA yang terdiri dari: 0 ppm (b 0 ), 20 ppm (b 1 ), 40 ppm (b 2 ). Faktor kedua adalah pemberian IBA 100 ppm (m 1 ), dan tanpa IBA (m 0 ). Hasil penelitian menunjukkan bahwa pemberian BA dengan konsentrasi 20 ppm menghasilkan pertumbuhan seedling terbaik dibandingkan dengan konsentrasi BA 0 ppm, dan 40 ppm. Pemberian IBA dengan konsentrasi 0 ppm dan 100 ppm, keduanya tidak menunjukkan perbedaan secara nyata terhadap pertumbuhan tanaman manggis. Konsentrasi benziladenin terbaik bagi pertumbuhan seedling manggis tidak bergantung pada pemberian IBA.
PENGARUH PEMBERIAN JUS BUAH DAN WARNA PADA PERANGKAP LIKAT TERHADAP JUMLAH TANGKAPAN LALAT BUAH DAN SERANGGA LAIN PADA PERTANAMAN CABAI MERAH
Authors: Kumbara A. M. , Swibawa I Gede , Hariri Agus M. , Hasibuan Rosma
Published: October 2018

Salah satu OPT yang sering menyerang dan menurunkan produksicabai merah adalah lalat buah. Penelitian ini bertujuan untuk mengetahui pengaruh warna pada papan perangkap dan pemberian jus buah terhadap jumlah tangkapan perangkap likat. Pemasangan perangkap likat dilaksanakan pada bulan Januari - Juni 2017 di Desa Candra Kencana, Kecamatan Tulang Bawang Tengah, Kabupaten Tulang Bawang Barat.Identifikasi serangga yang tertangkap di lakukan di Laboratorium Ilmu Hama Tumbuhan, Fakultas Pertanian, Universitas Lampung. Satuan Percobaan disusun dalam rancangan acak kelompok faktorial dengan 2 faktor (3 x 3) dengan 5 ulangan. Faktor I adalah jus yang terdiri dari 3 taraf : tanpa jus, jus jambu biji, dan jus belimbing. Faktor II adalah warna 3 taraf : tanpa warna (bening), warna hijau, dan warna kuning. Perangkap dipasang saat tanaman cabai mulai berbuah yaitu pada umur 12 minggu setelah tanam. Hasil penelitian ini menunjukkan bahwa penggunaanwarna kuning pada papan likat memberikan jumlah tangkapan yang lebih tinggi daripada warna lainnya. Penambahan jus belimbing pada perangkap likat menghasilkan jumlah tangkapan yang lebih tinggi dibandingkan jus lainnya. Kombinasi perangkap likat warna kuning dengan penambahan jus buah belimbing menghasilkan jumlah tangkapan lebih tinggi daripadakombinasi warna dan jus buah lainnya.
KAJIAN MEDIA TANAM HIDROPONIK DARI CAMPURAN BAHAN BAKU LIMBAH BAGLOG DAN ARANG SEKAM
Authors: Isworo Dyah , Triyono Sugeng , Haryanto Agus , Zulkarnain Iskandar
Published: October 2018

Penelitian ini bertujuan untuk mengetahui karakteristik sifat fisik media tanam diantaranya Uji Konsistensi (uji benturan dan rendam jenuh), Bulk Density Media, Daya Serap Air, Kekerasan, serta pH dan EC Media. Serta menganalisis pertumbuhan tanaman pak choi dengan media hasil pencampuran antara limbah baglog  dan arang sekam. Penelitian ini dilaksanakan di Jurusan  Teknik Pertanian Universitas Lampung pada bulan Juli – September 2017. Rancangan yang digunakan adalah rancangan acak lengkap dengan tiga ulangan. Faktor pertama adalah komposisi media  dengan 5 perlakuan yaitu limbah baglog, 2(balgog) : 1 (arang sekam), 1(baglog) : 1(arang sekam), 1 (baglog) : 2 (arang sekam), arang sekam. Faktor kedua adalah perekat dengan 3 perlakuan yaitu 0%, 10%, dan 20% dari berat media. Hasil penelitian menunjukkan bahwa media tanam arang sekam memiliki hasil tanaman terbaik jika dibandingkan dengan media tanam limbah baglog murni, namun terdapat perlakuan yang juga menghasilkan tanaman seperti perlakuan M4P3 (campuran 1 limbah baglog : 2 arang sekam + perekat 20%). Komposisi media berpengaruh terhadap kekerasan media, nilai BD media tetapi tidak berpengaruh terhadap daya serap air sehingga menghasilkan berat berangkasan segar yang beragam. Kombinasi perlakuan M5P2 (arang sekam murni + perekat 10%) memberikan hasil terbaik yaitu nilai daya serap air 352,1328%, BD media 0,5167 g/cm3 dan kekerasan media 3,6710 N/cm2. Kata Kunci:   limbah baglog, arang sekam, media tanam, hidroponik.
PENGENALAN PENGOLAHAN SUSU KAMBING DI KECAMATAN SUKADANA KABUPATEN LAMPUNG TIMUR [Introduction of Goat Milk Processing in Sub-district of Sukadana, District of East Lampung of the Lampung Province]
Authors: Wylis Ratna , Santri Novilia , Asnawi Robet
Published: October 2018

Milk is easily damaged when handling is poor, so it has a relatively short shelf life. To handle the excess milk production, the most appropriate step is to preserve milk to extend the shelf life through processing, and at the community level the consumption of processed milk is higher than the consumption of fresh milk. This research was conducted in Muara Jaya Village, Sukadana District, East Lampung Regency, from June to August 2016 with Mentari’s women farmer group as cooperator. The types of processed goat milk introduced are goat’s milk with spice flavoured, goat's milk ice cream with strawberry tasted, goat's milk ice cream with kweni tasted, and goat's milk caramel candy. The products of goat’s milk are tested on consumer preference and its counted breakeven price for each kind of product, so it is known how much the price of kind of processed goat’s milk if it want to commercialized. Observation parameters included, proximate analysis for fresh goat’s milk, consumer acceptance rate and break even price of each kind of product. Observation of consumer acceptance level is done by using hedonic scale (scale 1-5) from 20 panelists and breakeven price is calculated by comparing total production cost with yield produced. The collected data were analyzed statistically and if there was difference of the mean value was continued with DMRT test at 5% level. The results showed that the development of goat’s milk preparation is very pospective because goat’s milk has high protein content and low fat content so good for health; Processed goat’s milk produced introduced by the consumer, with a mean score> 3; The result of break even analysis shows that goat milk processing has prospect to be developed, because the price of its break even point is still reached by consumer that is: Rp.45.500, -/ liter goat’s milk spice flavoured;  Rp. 61.267/liter goat's milk ice cream strawberry tasted, Rp.55.933, -/ liter goat's milk ice cream kweni tasted, and Rp. 1.479 /goat's milk caramel candy.
STRATEGI PENGEMBANGAN AGROINDUSTRI JAMU DI JAWA TIMUR [Development Strategy of Herbal Medicine Agroindustry in East Java]
Authors: Nurmayasari Nurmayasari , Asfan Asfan , Mu'tamar Mohammad Fuad Fauzul
Published: October 2018

Herbal medicine agro-industry has experienced ups and downs in its development, the movement back to nature makes herbal medicine agro-industry has developed quite rapidly. This study aimed to determine the structure and factors that influence and determine the strategy of herbal medicine agro-industry development in East Java. The method used was OLS (Ordinary Least Square) and Backward method using secondary data, as well as the concentration ratio and PCM (Price Cost Margin) proxy. The results showed that the industrial market structure was tight oligopoly with an average concentration ratio of 76.22%. Influencing factors were market concentration, barriers to market entry, a value of efficiency and number of companies, while the strategy developed was to streamline raw material costs by implementing multiple supplier policies
PENENTUAN KUALITAS BUAH NAGA (Hylocereus undatus) DENGAN METODE NON-DESTRUKTIF [Non-destructive Determination of Dragon Fruit (Hylocereus undatus) Quality]
Authors: Khuriyati Nafis , Fibriato Muh Bayu , Nugroho Darmawan Ari
Published: October 2018

Sorting dragon fruit based on color, size, and physical defects using human senses does not adequately reflect the nutritional content of the fruit.  Nutrient content in dragon fruit has been determined by injuring fruit (destructive).  The objective of the research was to develop a non-destructive method based on color measurement to determine the quality of dragon fruit which includes texture, moisture content, total dissolved solids, and total acid.  Non-destructive color measurement used Chromameter to predict fruit maturity.  Based on the results of this fruit maturity prediction, dragon fruit quality was predicted by using a regression model between fruit maturity and each quality parameter.  Dragon fruit from various variations of maturity was used as a sample to find out its quality changes, and a regression equation was formed between the maturity of fruit and fruit quality.  The results showed that along with the increasing maturity of dragon fruit, color (La * b *), texture, moisture content, and total dissolved solids changed following a cubic regression model.  Color component "b" (yellowness) has the strongest relationship to fruit maturity (R2 = 0.95).  With the knowledge of fruit maturity based on these colors, the quality of dragon fruit could be determined through regression equations with results that were not significantly different from those with destructive methods, except total acid.