bluuebunny/crossref_metadata_2025 huggingface dataset:
Myeloma multiplex treatment and overall survival
Authors: Krstevska Balkanov Svetlana , Trajkova Sanja , Genadieva Stavric Sonja , Pivkova Veljanovska Aleksandra , Popova Labacevska Marija , Spasovski Dejan , Rambabova Bushljetik Irena , Kalcev Goce , Panovska Stavridis Irina
Published: February 2022

The Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines.
This retrospective-prospective study was conducted at the University Clinic for Hematology in Skopje, North Macedonia, in the period between January 2009 and December 2019. Patients younger than 65 years, without comorbidities, fit for autologous peripheral blood stem cell transplantation (PBSCT), were treated with Cyclophosphamide-Thalidomide-Dexamethasone (CyThalDex) protocol divided into two daily doses which were maintained until complete remission. Patients over 65 years of age, unfit for more aggressive treatment options like peripheral blood stem cells (PBSCT) with comorbidities and renal failure, were treated with Melphalan-Prednisone-Thalidomide (MPT) protocol. The third group of patients was treated without new immunomodulators such as thalidomide, but instead a salvage therapy was given consisted of chemotherapy and corticosteroids.
The use of thalidomide can lead to more undesirable effects such as deep vein thrombosis and renal neuropathy. The results obtained in our study showed no high percentage of these effects. However, a better survival rate was registered along with a longer period without progression of the underlying disease (PFS). Moreover, a higher percentage of complete remission (CR) was achieved and a very good partial response (VGPR) in general.
Myeloma multiplex is still incurable disease with pattern of regression and remission followed by multiple relapses rising from the residual myeloma cells, but in the future still many unsolved questions has to be answered.

Keywords: myeloma multiplex, autologous stem cell transplantation, thalidomide
The role of antibodies to peripheral nerve antigens in pathogenesis and laboratory evaluation of immune-mediated neuropathies
Authors: Mihajkoska Evgenija , Poceva Panovska Ana , Brezovska Katerina , Pendovska Marija , Taravari Arben , Suturkova Ljubica
Published: February 2022

Detection of antiganglioside autoantibodies and their association with clinically defined subtypes implicate an autoimmune mechanism of peripheraland cranial nerve damage in peripheral neuropathies.
Increased titer of antibodies that react with human peripheral nerve antigens have been reported in patients with motor neuropathy including Guillain-Barré syndrome,chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy and sensory motor neuropathy. This study represents review of the data related to increased titers of anti-glucoconjugate antibodies in different autoimmune neuropathies and their correlation with existence of structural homology between bacterial and glycoconjugated structures, as a basis for understanding the immune pathological response to glycoproteins and glycolipids present in the human peripheral nerve as target antigens in autoimmune neuropathies.
Evaluation of presence and increased level of autoantibodies against peripheral nerve antigens could be an important parameter in laboratory evaluation, diagnosis and prognosis of autoimmune neuropathies and contribute in more efficient therapeutic approaches in treatment of these pathological conditions.

Keywords: anti-glycoconjugate antibodies, anti-ganglioside antibodies, peripheral nerves, autoimmune neuropathies
SURVEY KETERSEDIAAN PESTISIDA HAYATI DI PROVINSI BENGKULU
Authors: Lena Magda
Published: February 2022

PESTISIDA HAYATI DI PROVINSI BENGKULU
KERAGAAN HASIL DAN KOMPONEN HASIL BEBERAPA VARIETAS KEDELAI PADA LINGKUNGAN GENANGAN
Authors: Artari Rina
Published: February 2022

The research aimed to evaluate the yield performance and yield components of several soybean varieties against the waterlogging environment. The research was conducted at the Balitkabi in February until May 2017. The experimental design used Randomized Block Design with two factors and four replications. The first factor is optimal environmental  (L1) and waterlogging environment (L2). The second factor is soybean varieties. The varieties used in this study were 3 varieties of soybeans (Grobogan, Demas 1, and Dega 1). In the optimal environment  (L1), the plants were planted in buckets that were planted under normal conditions . In the waterlogging treatment (L2), the polybags filled with soil and put into a wooden tub and added water. Waterlogging treatment is carried out after the plants are 21 days after planting, the wooden tub is filled with water to a height of 5 cm from the soil surface in the polybags (the plants are in submerged). The fertilizer used in this research was 15% N, 15% P2O5, 15% K2O with a dose of 1.5 g / polybags or the equivalent of 250 kg ha-1 which was applied at planting. Observations were made on the character of the pods per plant,  seeds per plant, seed weight, plant height, shoot fresh weight and shoot dry weight, root fresh weight and root dry weight and chlorophyll index. The waterloggingresulted in a decrease in yield components and soybean yield compared to the optimal environment. Waterlogging increased the root dry weight. Grobogan and Dega 1 varieties produced higher seed weights than Demas 1 varieties in waterlogging environments. Keywords: Yield and Yield Component, Soybean, Waterlogging
KEANEKARAGAMAN TERIPANG (Holothuroidae) DI ZONA INTERTIDAL PADA AREA KONSERVASI “SASI” KAMPUNG FOLLEY DISTRIK MISOOL TIMUR KABUPATEN RAJA AMPAT - PAPUA BARAT
Authors: Sabariah Vera
Published: February 2022

Sasi adalah kearifan lokal dari masyarakat di Papua untuk menjaga kelestarian sumberdaya termasuk biota perairan.  Penelitian ini bertujuan untuk mengkaji keanekaragaman teripang (Holothuroidae) di perairan Kampung Folley Distrik Misool Timur kabupaten Raja Ampat. Lokasi penelitian yang terdiri dari 2 lokasi konservasi sasi teripang yaitu perairan Tanjung Vageta dan Tanjung Waponta, serta 1 lokasi di luar area konservasi yaitu Perairan Dermaga Kampung Folley. Pengambilan data pada bulan Juni-Juli 2019 dilakukan menggunakan kuadran 5x5m2 diletakkan zigzag dengan transek garis 100m sejajar garis pantai.  Terdapat 7 spesies teripang di lokasi konservasi sasi yakni Holothuria scabra1, H. scabra2, H. atra, H. leucuspilota, H. impatiens,  Stichopus hermanii, Synaptidae. H. scabra adalah yang terbanyak di area konservasi sasi dan merupakan komoditas penting bagi masyarakat lokal. Kata Kunci: teripang, Holothuroidea, area konservasi “sasi”, Raja Ampat`
The potential applications of artificial intelligence in drug discovery and development
Authors: Farghali H , Kutinová Canová N , Arora M
Published: February 2022

Development of a new dug is a very lengthy and highly expensive process since only preclinical, pharmacokinetic, pharmacodynamic and toxicological studies include a multiple of in silico, in vitro, in vivo experimentations that traditionally last several years. In the present review, we briefly report some examples that demonstrate the power of the computer-assisted drug discovery process with some examples that are published and revealing the successful applications of artificial intelligence (AI) technology on this vivid area. Besides, we address the situation of drug repositioning (repurposing) in clinical applications. Yet few success stories in this regard that provide us with a clear evidence that AI will reveal its great potential in accelerating effective new drug finding. AI accelerates drug repurposing and AI approaches are altogether necessary and inevitable tools in new medicine development. In spite of the fact that AI in drug development is still in its infancy, the advancements in AI and machine-learning (ML) algorithms have an unprecedented potential. The AI/ML solutions driven by pharmaceutical scientists, computer scientists, statisticians, physicians and others are increasingly working together in the processes of drug development and are adopting AI-based technologies for the rapid discovery of medicines. AI approaches, coupled with big data, are expected to substantially improve the effectiveness of drug repurposing and finding new drugs for various complex human diseases.
BÖBREK İSKEMİ-REPERFÜZYON HASARINDA KALPAİN İNHİBİTÖRÜ OLAN AK295 UYGULANAN SIÇANLARDA SERUM ÜRE VE KREATİN DEĞERLERİ
Authors: AYDEMİR Songül , BİNEN Mahmut
Published: February 2022

Nekroz ve apoptoz gibi hücre ölümü ile sonuçlanan olaylarda kalpainler, kaspazlarla birlikte çalışan proteazlardır. Sıçan omurilik travma modellerinde kalpain inhibitörlerinin (AK295) apoptozu yavaşlattığı veya durdurduğu bilinmektedir. Bu çalışmada 28 adet erkek wistar albino sıçan rastgele seçilerek dört gruba ayrıldı. Gruplar; kontrol, İskemi-Reperfüzyon (İ/R), İskemi-Reperfüzyon+AK295, İskemi-Reperfüzyon+DMSO (dimetil sülfoksit) olarak belirlendi. İskemi sonrasında böbreklerde oluşan hasarda kalpain inhibitörü olan AK295’in etkisi incelendi. Sıçanlara sağ böbrek nefrektomisi uygulanarak 30 dakika total iskemi yapıldı. 24 saatlik reperfüzyon periyodu tamamlandıktan sonra anestezi uygulandı. Bu çalışmamızda, böbrek hasarında önemli indikatörler olan serum kreatin ve üre değerleri tayin edildi. Kontrol, I/R, I/R + AK295, and I/R + DMSO gruplarında ortalama üre değerleri; sırasıyla 35.4 ± 22.3, 156.4 ± 9.01, 150.8 ± 5.8, ve 165.2 ± 6.1 mg/dL olarak bulundu. İ/R + AK295 ve İ/R + DMSO değerlerinin, kontrol grubuna göre anlamlı (p<0.05) derecede yüksek olduğu bulunmuştur. Böbrekte İ/R oluşturulan sıçanlarda, AK295’in oluşan böbrek hasarını kısmen azalttığı tespit edildi.
Cognitive Function, Aging, and the Community Dwelling Elderly Living Alone: Implications for Nursing Practice
Authors: Sleeper Tanya L.
Published: February 2022

The growth in the aging population in the coming years represents a significant public health policy issue as more and more older adults wish to age in place. Additionally, as more older adults live longer, more older adults are living at home alone. Cognitive function and cognitive decline in later life represent additional challenges to the vulnerable elderly. As the health care system grapples to meet the needs of a growing aging population, the nursing profession can play an important role in health promotion and prevention efforts in cognition and aging. Given the need to advance more routine screening and assessment of cognition in later life, nurses are well poised to advance science and research and support recommendations for assessing cognitive function and cognitive decline in order to support safe and autonomous living in advanced age.
Asynchronous Online Simulation in Nursing Education: Creating Learning Opportunities to Meet Current Challenges
Authors: Nadelson Sandie , Nadelson Louis , Connor Kelley
Published: February 2022

Online simulations are growing in popularity to reduce the reliance on clinical sites and simulation laboratories to enhance students’ skills and abilities. Many nursing programs are investigating how to expand their online simulation offerings. Deciding on the best online simulation modality for enhancing learning can be difficult as many options are available. Choices include performing simulations “live” in “real-time,” called synchronous learning or asynchronous, which means this happens when the instructors and other students may not be present. In deciding how to increase programs’ simulation offerings, options for online asynchronous simulations include developing your own simulations, utilizing no-cost web-based simulations, or purchasing access to previously developed online simulations offered by proprietary companies. Each online simulation type has benefits and limitations. In this article, we cover the pros and cons of these options. The information about online asynchronous simulations included will assist nurse educators in making informed choices to meet their targeted learning outcomes.
COMPARATIVE GROWTH PERFORMANCE AND ACTIVITY OF DEFENSE RELATED ENZYMES AND GENE EXPRESSION IN RUBBER CLONES AGAINST RIGIDOPORUS MICROPORUS INFECTION
Authors: Syafaah Afdholiatus , Woraathakorn Natthakorn , Plodpai Patimapon , Nualsri Charassri , Nakkanong Korakot
Published: February 2022

Rigidoporus microporus is the causal agent of rubber white root disease (WRD). Control of this is commonly carried out by chemical treatment. The use of tolerant rootstocks may present an effective method to lessen its impact. The screening of rubber rootstocks for tolerance of WRD was investigated by both defense-related enzymes and gene expression, and assessment of disease symptoms.Two recommended clones in Thailand (RRIT251 and RRIT408) and RRIM623 (Malaysian clone) were screened and compared with susceptible clones (RRIM600 and BPM24) and tolerant clone (PB5/51) by inoculating young rubber seedling with R. microporus. The expression of PRs and PAL were analyzed at 0, 1, 3, 5, and 7 days post inoculation (dpi) along with the defense-related enzyme activities. Based on observed transcriptional level of PRs and PAL genes, CHI, PAL, and POD enzyme activities, and also evidence from WRD symptom assessment in the field, we concluded that PB 5/51 had the best tolerance with the lowest disease incidence, high PAL and POD enzyme activities, with the next best being RRIM 623 and RRIT 251, respectively. Meanwhile, BPM 24, RRIM 600, and RRIT 408 clones are moderately susceptible to WRD. The study introduces new possibilities for the control of WRD using alternative rubber rootstock clones.
EFFECT OF PROPIONIC ACID AND MIXED WAX (BEE-CARNAUBA WAX) ON TOTAL MICROORGANISM AND QUALITY OF PURPLE PASSION FRUIT AT AMBIENT TEMPERATURE
Authors: Huyen Nguyen Thu , Duc Nguyen Minh
Published: February 2022

The effects of propionic acid and mixed wax (bees and carnauba wax; MW) on total microorganisms and quality of purple passion fruit at ambient temperature 25±2°C and 70%–80% relative humidity were studied. The fruits were dipped in propionic acid solution at the concentrations of 0.15%; 0.25%; 0.35% (v/v) and 0.2% carbendazim, then coated with MW 2.5% by hand. After drying, they were stored at 25 ± 2 °C for 18 days. Uncoated fruits were preserved at the same temperature as control. The determination parameters were isolation and identification of microorganisms, total microorganism, percentage of fruit decay, weight loss, total soluble solids content (TSS), total sugars, titratable acidity, and ascorbic acid content; interval time was every 3 days of storage time. The results showed that identified two kinds of microorganism were Fusarium moniliforme var. subglutinans and Fusarium oxysporum Schlecht. The concentration of 0.25% propionic acid solution and MW coating could reduce the percentage of weight loss, fruit decay, and total microorganisms for 18 days of storage time. Moreover, this combination could remain chemical qualities, as TSS, total sugars, titratable acidity, ascorbic acid content in 18 days of storage time.
Identidade da Universidade Privada no Contexto Midiático de Mercantilização de Ensino frente a Indústria Cultural / The Identity of the Private University in the Media Context of Commercialization of Education in the face of the Cultural Industry
Authors: Andrade Tiago Negrão de , Ramirez Bruna Fernanda Damasceno , Morais Osvando José
Published: February 2022

A teoria crítica continua sendo muito atual para a universidade privada,  seu repertório, sua vocação  culturalista, que passou por sérias transformações culturais. Uma instituição complexa que atua de modo  integrado o ensino, a pesquisa e a extensão acaba sendo cobrados diante das crises sociais. Revisou-se os  efeitos críticos na ideia da comercialização da educação, sob o efeito da publicidade e propaganda das  campanhas dos vestibulares, sob o prisma do capitalismo social. São pelas diretrizes organizacionais e  relações públicas, tais como visão, missão, valores, filosofias, crenças, como bem definindo em seu  Estatuto e Regimento, que seus materiais de comunicação institucional, mercadológica e administrava  norteiam jovens e propósitos.
The effects of care-oriented group discussion on burnout among the caregivers of patients with stroke
Authors: Sharifian Pegah , Mohammadi Fatemeh , Ranjbaran Faezeh , Kamyari Naser , Shamsizadeh Morteza
Published: February 2022

Background and aims: Patients with chronic illnesses such as stroke have different physical and mental problems and need the care and support of their family members. Family caregivers face many different problems and experience burnout during caregiving to their patients. The aim of this study was to investigate the effects of care-oriented group discussion (GD) on burnout among the caregivers of patients with stroke. Methods: This two-group pretest-posttest quasi-experimental study was conducted in 2019. Participants were forty family caregivers of patients with stroke randomly selected from the neurology and stroke care ward of Sina hospital, Hamadan, Iran. They were randomly allocated to two twenty-person groups. Participants in the control group received routine care services, while participants in the intervention group received routine care services in addition to care-oriented GD in six two-hour sessions. Burnout was assessed before and two weeks after the study intervention and the SPSS program (v. 22.0) was used to analyze the data through the Kolmogorov-Smirnov, paired-sample t, independent-sample t, and Chi-square tests. Results: Groups did not significantly differ from each other respecting the pretest mean scores of burnout and all its dimensions as well as the posttest mean scores of the personal and financial dimensions of burnout (P > 0.05). However, the posttest mean scores of burnout and its social and emotional dimensions in the intervention group were significantly less than the control group (P < 0.05). Conclusion: As an effective strategy, care-oriented GD can be used to reduce burnout among the family caregivers of patients with stroke.
Conflict effects of autophagy on cellular senescence in advanced ages: A systematic review
Authors: Rezabakhsh Aysa , Hosseinifar Hossein , Vahed Nafiseh , Salehnia Fatemeh
Published: February 2022

Introduction: Recently, autophagy as a highly conserved catabolic intracellular process is considered a promising therapeutic target, particularly in pathological alternations under aging conditions. This systematic review was designed to qualitatively analyze the interaction between autophagy and aging in various organs of animal models. Methods: Based on our primary search, 9478 articles were identified, and following the screening, ultimately, 80 full texts were included to proceed with further analysis. Next, using SPSS software, data analysis of autophagy and aging-related markers and autophagy alternation throughout aging, was performed. Results: Despite debatable results, we established that the most of studies showed that the autophagy process reduced in different aged organs significantly. Conclusion: The outcomes demonstrated that autophagy induction during aging was inferior to those reports that indicated the therapeutic potential of autophagy. Taken together, it should be considered that autophagy inducers could be counted as anti-aging agents.
Antioxidants and Their Role in Preventing Diseases: A Review
Authors: Hassan Ekhlas Abdallah , Al-Zuhairi Wafaa Sh. , Ibrahim Wijdan Amer
Published: February 2022

Antioxidants are natural materials that may delay or stop some kinds of hurt in cells. Many foodstuffs have antioxidants, such as fruits and vegetables. Even though the reactions of oxidation are critical for life, but can also be harmful; vegetation and faunae preserve multifaceted systems of various types of antioxidants, for example, vitamin C, vitamin E, and vitamin A besides enzymes like superoxide dismutase, catalase and many peroxides. The most important antioxidant source that protected ancient peoples from the harm caused by free radicals was old-style herbal remedies and dietetic diets. In addition, it is broadly utilized in dietetic supplements and have been studied for their potential to prevent diseases such as tumors and coronary heart disease. Although preliminary research suggested that antioxidant supplements could be beneficial to one’s health. Furthermore, clinical trials of antioxidant supplements containing beta-carotene, vitamin A, and vitamin E alone or in various combinations show that supplementation has no effect on the rate or may even increase it. Antioxidants are also used in the food industry as food additives and cosmetics, as well as to prevent rubber and fuel degradation.
EFEKTIFITAS PENERAPAN ABSENSI FINGER PRINT TERHADAP DISIPLIN PEGAWAI DI KANTOR KECAMATAN SORAWOLIO KOTA BAUBAU
Authors: Nani Anong , Wijaya Andy Arya Maulana
Published: February 2022

Pemanfaatan Teknologi Informasi menjadi salah satu daya dukung dalam proses pemerintahan, khususnya dalam penerapan absensi finger print untuk mengawasi kehadiran pegawai. Teknologi ini juga digunakan pada Kantor Kecamatan Sorawolio Kota Baubau, namun dalam implementasinya dianggap belum berjalan efektif dan efisisen. Penelitian ini mengkaji dampak penerapan model absensi finger print dan sejumlah faktor yang memengaruhinya. Tujuan dari penelitian ini adalah untuk mengetahui dampak penerapan absensi finger print terhadap disiplin Pegawai Negeri Sipil di Kantor Kecamatan Sorawolio Kota Baubau. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Data penelitian diperoleh melalui sejumlah Informan pegawai di Kantor Kecamatan Sorawolio. Pengumpulan data dilakukan dengan wawancara mendalam, studi dokumen dan observasi langsung oleh peneliti.

Hasil Penelitian ini menunjukkan bahwa penerapan absensi finger print pada pegawai Kantor Kecamatan Sorawolio cenderung meningkatkan disiplin terhadap kehadiran pegawai, dengan dukungan adanya data yang tercatat secara detail tentang ketepatan pegawai masuk maupun pulang kantor. Namun dalam penerapan teknologi absensi finger print ini, masih menemui beberapa kendala diantaranya keterlambatan jam masuk pegawai serta aksesibilitas pegawai jika berkaitan dengan tempat tinggal dan lokasi kegiatan. Sehingga masih sering ditemui adanya pegawai yang sering datang terlambat maupun pulang yang lebih cepat dari jadwal. Diharapkan melalui hasil kajian ini menjadi bahan koordinasi Camat Sorawolio dengan Pemerintah Kota Baubau untuk dilakukan perbaikan aturan dan sistem kerjanya terhadap pemantauan kedisiplinan pegawai di Kota Baubau.
PROBLEMATIKA DEMOKRASI PRESIDENSIL PASCA PERUBAHAN UNDANG-UNDANG DASAR
Authors: Zaini Abdul Aziz , Maturidi Maturidi
Published: February 2022

Abstract After the changes to the Constitution (UUD), Indonesia, which previously adopted a parliamentary system of government, turned into a presidential system of government, which still has many democratic problems. These changes also have implications for changes in the government system, including The President is directly elected by the people through general elections, the Position of the People's Consultative Assembly (MPR) which was previously the highest state institution to be a high state institution, Strengthening the role and authority of the House of Representatives (DPR) in the field of legislation and oversight of the executive. One of the provisions which strongly indicates the strength of the presidential system in the 1945 Constitution is Article 7C, which states that the President cannot freeze and/or dissolve the DPR. Historically, many have argued that this article was raised as a response to the statement of former President Abdurrahman Wahid, who had issued a decree to dissolve the DPR when he served as President of the Republic of Indonesia.
IMPLEMENTASI E-GOVERNMENT PADA PEMERINTAH DAERAH
Authors: Karman Karman , Deswanto Rudi , Ningsih Sri Adhi
Published: February 2022

E-Government or Electronic-Based Government System is a concept carried out by government institutions in providing services to the community more effectively and efficiently. There are problems that continue to occur related to the development of the Electronic-Based Government System, namely the security sector. The security sector must be the focus in implementing public services. The amount of information that must be managed with a high level of sensitivity. Serious attention is needed on how safe conditions are in developing the implementation of an Electronic-Based Government System. This study uses the Systematic Literature Review method to be able to identify and analyze research trends related to the level of security in Electronic-Based Government Systems collected from 2015-2019. The results of this study indicate that there are many factors that require the government to prioritize more safety factors in implementing SPBE. In addition, there are various solutions in the form of models/frameworks in solving problems in applying the concept of security to an Electronic-Based Government System.
PERAN DINAS PARIWISATA KOTA BAUBAU DALAM PENGEMBANGAN WISATA BATU SORI
Authors: Gufran La , Nastia Nastia
Published: February 2022

This study aims to determine the role of the Baubau City Tourism Office in the Development of Batu Sori Tourism. This research uses descriptive research with a qualitative approach, which is a research method used to examine the condition of natural objects, so the researcher is the key instrument. The results showed that the role of the Baubau City Tourism Office and the Palabusa Village Government in developing stone tourism was carried out through cooperation and encouraging the community and local government to always coordinate. This is in line with the role of the Tourism Office and the Village Government in providing motivation which aims to support the maximization of Batu Sori tourism. Likewise in Batu Sori Tourism Development, the Tourism Office of Baubau City carries out a maintenance program for the Batu Sori tourist area which involves the community as tourism actors with quality infrastructure and facilities that are in accordance with the needs of tourists, and for foreign tourists welcoming activities.
Efficiency from a pneumatic system to a mechanical traction system
Authors: Peralta-Meza Angel , Pendones-Fernández José Angel , Durán Núñez Félix Arnoldo
Published: February 2022

Pneumatic traction systems have already been used since Denise Papín, who apparently already had the idea of using compressed air in cars. Currently in Uruguay and India with Armando Miguel Regusci Campomar and the French inventor Guy Negre respectively, they make use of this energy and mention high efficiency in their compressed air motors. In this vein and in order to continue research with this energy, explore non-polluting alternative energies and their efficiency, a Pneumatic-Mechanical traction system is proposed in this research, in a mobile of our own manufacture. The system works under two principles of elementary physics; Pascal's pneumatic energy and Tesla's alternating pneumatic energy that is, alternating pneumatic energy, their efficiency is tested with the energy of the compressed air tank and the displacement energy of the mobile
Viable model of the Mexican legal system: A transdisciplinary systemic vision
Authors: Patiño-Ortiz Ana Alejandra , Villagrán-Villegas Luz Yazmín , Martínez-Cruz Miguel Ángel , Anzelmetti-Zaragoza Juan Carlos
Published: February 2022

In Mexico, the Legal System contemplates a broad set of agencies responsible to the justice imparting, therefore for its management it is necessary to have a systemic model that allows to contribute, in a more adequate way, to the entire set of subsystems; in such a way that the institutions responsible to administering justice are capable of accurately and expeditiously determining the results and conclusions in the areas responsible to the administration of justice. The implementation and application of models with a systemic approach, such as Viable Systems Models, allow us to respond to many problems at different integrated levels of abstraction of sociotechnical systems, such as those responsible to justice administration in Mexico. This research work purpose is to design a Viable Model for the Mexican Legal System, which will allow to provide justice delivery systems with a tool that streamlines, and facilitates the management, control and handling of the information used in the National Legal System. The systems approach application in the design of viable systems allows to unite different expert’s views to give a comprehensive response to the analyzed cases.
Redesigning a product: Assembly, manufacture and production strategies
Authors: Ojeda-Escoto Pedro Agustín
Published: February 2022

In the design of a product, several factors are involved to define it as functional and is also important to clearly state its life cycle. On the other hand, the participation of the client or end user is very important for the approach of the main specification and with the purpose of conforming a product that has ample possibilities of competition in the global market. Looking for the consolidation of a new product, in the present work the redesign of a harvester (case study) was carried out. For the proposal of the new design, the reference framework is based on design for disassembly (DFD) to propose the development of the technical process and design for manufacturing (DFM) to optimize the production process. Is also presented the procedure used to structure the harvester redesign under the approach of production quality improvement and cost reduction, which helped to define a final functional configuration able to be aligned to mass production.
Design and optimization of a renewable hybrid system applied in airports
Authors: Absalon-Soto Dorian Hugo , Gómez-Gónzalez Francisco Javier
Published: February 2022

This paper shows the development of a methodology for the optimization of a hybrid generation system applied in airports. First, the renewable resources available in the area are characterized, the commercial demand profile of electricity consumption is obtained, and the system configuration is proposed. Later, we proceed to the optimization, where the simulation tool HOMER is used for this purpose. The software can determine the net present cost (NPC) and the cost of energy (COE) of different combinations. With the information obtained, it is possible to find the optimal combination of components to satisfy the load demand at the most affordable cost. The proposed methodology is applied to the General Heriberto Jara Corona International Airport, with the purpose of reducing the costs of electric energy consumption and greenhouse gas (GHG) emissions, considering the aeronautical physical easements established by the International Civil Aviation Organization (ICAO). Finally, the profitability of the optimized renewable system is evaluated, thus contributing to sustainable development of the airport.
Occupational Accidents among Fishermen in Manado, North Sulawesi
Authors: Suhartoyo Fitri M. , Sumampouw Oksfriani J. , Rampengan Novie H.
Published: February 2022

Abstract: The International Labor Organization (ILO) noted that at global level more than 2.78 million people die per year due to occupational accidents or work-related diseases. In addition, there are approximately 374 million injuries and illnesses resulting from non-fatal occupational accidents each year. The Food and Agriculture Organization (FAO) in "The State of World Fisheries and Aquaculture" reported, as many as 24,000 fishermen per year died at sea during fishing activities. This study aimed to identify the prevalence of occupational accidents among fishermen in Manado City, North Sulawesi. This was a quantitative and analytical survey study using the cross-sectional design. This study was conducted at the Coastal Fishing Port Manado City, North Sulawesi and respondents were 264 fishermen. The instrument used in this study was a questionnaire that had been tested for validity and reliability. The results showed the prevalence of occupational accident was 70.8%. The description of the respondents’ occupational accidents showed that the most common experienced accident was injury as many as 47.7%, and the most injured body part was the hand as many as 37.1%. In conclusion, the prevalence of occupational accident among fishermen in Manado, North Sulawesi is still high.Keywords: work accident; fishermen Abstrak: International Labour Organization (ILO) mencatat, di tingkat global lebih dari 2,78 juta orang meninggal per tahun akibat kecelakaan kerja atau penyakit terkait pekerjaan. Selain itu, ada sekitar 374 juta cedera dan penyakit akibat kecelakaan kerja non-fatal setiap tahun. Food and Agriculture Organization (FAO) dalam "The State of World Fisheries and Aquaculture" melaporkan, sebanyak 24.000 nelayan per tahun meninggal dunia di laut pada saat kegiatan penangkapan ikan. Penelitian ini bertujuan untuk mengidentifikasi prevalensi kecelakaan kerja pada nelayan di Kota Manado Sulawesi Utara. Jenis penelitian ialah kuantitatif dengan rancangan penelitian survei analitik, menggunakan desain potong lintang. Penelitian ini dilakukan di Pelabuhan Perikanan Pantai (PPP) Kota Manado Sulawesi Utara. Responden penelitian berjumlah 264 nelayan. Instrumen penelitian berupa angket yang telah diuji validitas dan reliabilitasnya. Hasil penelitian mendapatkan bahwa prevalensi kecelakaan kerja sebesar 70,8%. Gambaran kecelakaan kerja responden menunjukkan bahwa jenis kecelakaan yang dialami paling banyak ialah mengalami luka sebesar 47,7%, dan bagian tubuh yang mengalami cedera paling banyak ialah pada bagian tangan sebesar 37,1%. Simpulan penelitian ini ialah prevalensi kecelakaan kerja pada nelayan di Kota Manado, Sulawesi Utara masih tinggi.Kata kunci: kecelakaan kerja; nelayan
Domestic Violence in COVID-19 Pandemic Era from January to September 2021 in Manado
Authors: Pangalila Phoebe C. A. , Siwu James F. , Mallo Nola T. S.
Published: February 2022

Abstract: Domestic violence has been reported globally in various countries, including Indonesia. The COVID-19 pandemic has intensified this issue, regardless the decrease shown in the number of cases reported. This study aimed to obtain the incidence rate of domestic violence, its influencing factors, and forms of domestic violence during the COVID-19 pandemic in Manado from January to September 2021. This was a retrospective and descriptive study with a cross-sectional design. Secondary data were domestic violence cases reported in Manado Women Empowerment and Child Protection Service. The results showed 11 reported cases. Mapanget and Wanea were districts that received the most reports. Victims were dominated by females who were wives, children, or niece of the perpetrators, aged under 18 years old, mostly under 5 years old. Household neglect was the most form of domestic violence. In conclusion, domestic violence cases reported in Manado from January to September 2021 were dominated by female victims and children of the perpetrators. The COVID-19 pandemic and patriarchal culture were suspected as indirect triggers in terms of household neglect as the most common form of domestic violence.Keywords: COVID-19 pandemics; domestic violence Abstrak: Kekerasan domestik (KDRT) telah dilaporkan secara global di beragam negara, termasuk Indonesia. Pandemi Covid-19 turut memperhebat kasus ini walaupun jumlah laporan kasus justru menurun. Penelitian ini bertujuan untuk memperoleh gambaran angka kejadian KDRT, faktor yang memengaruhinya, serta bentuk KDRT di Kota Manado pada saat pandemi Covid-19 periode Januari–September 2021. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang menggunakan data sekunder, yakni laporan kasus KDRT yang dikumpulkan dari Dinas Pemberdayaan Perempuan dan Perlindungan Anak Kota Manado. Hasil penelitian mendapatkan 11 kasus terlapor, dengan Mapanget dan Wanea sebagai kecamatan yang menerima laporan terbanyak. Korban didominasi oleh perempuan yang merupakan istri, anak, serta keponakan pelaku yang berusia di bawah 18 tahun, terbanyak ialah anak berusia kurang dari 5 tahun. Bentuk kekerasan terbanyak dialami ialah penelantaran rumah tangga. Simpulan penelitian ini ialah kasus KDRT terlapor di Kota Manado pada Januari-September 2021 didominasi oleh korban berstatus anak pelaku berusia kurang dari 5 tahun dan berjenis kelamin perempuan.  Pandemi Covid-19 dan budaya patriarki disinyalir menjadi pemicu tidak langsung dilihat dari penelantaran rumah tangga sebagai bentuk KDRT terbanyak.Kata kunci: pandemi Covid-19; kekerasan dalam rumah tangga
Pengaruh Motivasi Kerja Islami Terhadap Kinerja Karyawan
Authors: Yusuf Mahmud
Published: February 2022

Tujuan dari penelitian ini adalah untuk menguji pengaruh etika kerja Islami terhadap prestasi kerja dan motivasi intrinsik. Penelitian ini juga mencoba untuk menyelidiki peran mediasi motivasi intrinsik pada hubungan antara Etika Kerja Islami dan prestasi kerja. Nonprobability sampling, metode yang digunakan. Data dikumpulkan melalui kuesioner yang dari 310 karyawan dari berbagai perusahaan di Kalimantan Selatan. SPSS dan AMOS digunakan untuk uji statistik. Hasil empiris menunjukkan bahwa terdapat hubungan positif yang signifikan antara etika kerja Islami, Prestasi kerja dan motivasi intrinsik. Lebih lanjut, penelitian menjelaskan bahwa motivasi intrinsik memediasi hubungan antara Etika Kerja Islami dan Prestasi Kerja. Implikasi dan rekomendasi penelitian yang akan datang dibahas dalam kesimpulan. Studi ini menunjukkan bahwa efek IWE pada JP dan IM sangat signifikan. Studi ini menemukan banyak hasil bahwa tidak hanya IWE secara langsung mempengaruhi JP dan IM, tetapi juga secara tidak langsung melalui efek mediasi dari IM. Studi ini mengisi kesenjangan khususnya dan harus kooperatif bagi manajer organisasi yang dapat membangun dan meningkatkan keterampilan mereka untuk menilai perilaku karyawan yang mereka puas dan setia dengan pekerjaan mereka. Jika pekerja merasa puas dengan pekerjaannya, maka akan meningkatkan kinerja karyawan seiring dengan kinerja organisasi dengan memiliki pengaruh optimis dan penting pada organisasi.
Pengaruh Pendidikan Karakter Bela Negara Terhadap Ancaman Nyata Ke Depan
Authors: Setiyowati Harlis , Akbariani Nurhaliza Vania
Published: February 2022

Penyelenggaraan pendidikan layanan khusus bagi anak-anak jalanan perlu pendampingan secara terus menerus. Tujuan penelitian ini adalah upaya untuk mengurangi ancaman nyata kedepan melalui penguatan pendidikan karakter bela negara (PPKBN) yang dilaksanakan di lingkungan sekolah,  lingkungan keluarga, lingkungan masyarakat dan di lingkungan Negara. Penelitian ini menggunakan pendekatan kuantitatif  dan kualitatif dengan metode survei. Hasil penelitian yaitu variabel PPKBN Di Lingkungan Masyarakat (X3) lebih besar dari variabel PPKBN Di Lingkungan Negara (X4),  diikuti oleh variabel  PPKBN Di Lingkungan Sekolah (X1) dan variabel PPKBN Di Lingkungan Keluarga (X2). Semakin tinggi kualitas PPKBN Di Lingkungan Masyarakat maka akan sangat kuat dengan tingginya kualitas Pengurangan Ancaman Nyata Ke Depan (Y) itu sendiri. 
CYTOLOGICAL AND HISTOPATHOLOGICAL CORRELATIVE STUDY OF LYMPH NODES IN A TERTIARY CARE HOSPITAL
Authors: M Muthukumar , Devi E Prema , T Jaishree , M Saraswathy , G Sarumathy
Published: February 2022

Context: 1
Lymph nodes are one of the most frequently sampled tissues and lymphadenopathy are rst evaluated by ne needle aspiration cytology .
Lymphadenopathy is one of the commonest presentations in surgical department with varied etiology ranging from Reactive, Inammatory
condition to malignancy.
Aims: The aim of present study was to evaluate the correlation between the cytological and histopathological diagnosis of lymph node FNAC and
Biopsies and to evaluate the sensitivity, specicity and predictive value of FNAC of lymph nodes diagnosed as tuberculosis and metastatic
carcinoma.
Settings and Design: The study is done in SMMCHRI for a period of one year which included a total of 174 patients referred from surgical
department who underwent FNAC of lymph nodes, out of which 89 patients had lymph node biopsies for histopathological evaluation.
Methods and Material: Aspiration smears and histopathological slides were evaluated and results were calculated for sensitivity, specicity and
predictive value of FNAC and henceforth Cytological and Histopathological correlation is studied.
Statistical analysis used: Sensitivity, Specicity, Predictive value and Diagnostic accuracy are calculated
Results: Reactive lymphadenitis was seen in 35 patients followed by tubercular granulomatous lymphadenitis in 26 patients and malignant lesions
in 28 patients. Correlating the ndings, we could achieve 100% sensitivity and 96.9% specicity for tubercular lymphadenopathy and 100% and
98.6% for metastatic deposits respectively.
Conclusions: We have found FNAC as a satisfactory tool in diagnosis of tubercular and malignant lymphadenopathy. FNAC when used in
conjunction with clinical, radiological and laboratory investigations can be a cost-effective method for the diagnosis of lymphadenopathy
EVALUATATION OF RIB VARIATIONS IN CHEST RADIOGRAPH
Authors: Reddy B.S Mahendranath , Jonnalagadda Komali , Ramakrishnan Karthik Krishna , Gunasekaran Veeraraghavan , Muralidharan Yuvaraj , Pitchandi Muthiah , Rajan Seena Cheppala
Published: February 2022

Rib variations are usually incidental ndings on imaging studies and are rarely symptomatic. If in adequately evaluated they are easily overlooked
as most of the X-ray is aimed at evaluating the lung parenchyma. Trauma related lesions might usually be misinterpreted as rib variations and
sometimes rib lesions may mimic a variant of rib and radiologists should be familiar with a number of normal variants of the ribs to avoid mistaking
them for an abnormality. In this article we will discuss and illustrate variety of anatomical rib variants and their incidence in this given population.
Anatomical rib variants include developmental deformities, cervical rib, Bid (forked), fused rib and hypertrophied transverse process of C7 be
used. The aim of our study is to have a comprehensive evidence-based morphological assessment of normal anatomical variations of ribs and their
prevalence in this population. A Retrospective study of Chest radiographs of 1000 adults who visited our hospital for a routine check-up or for
various medical examinations from September 1st 2018 to September 30th 2018, were consecutively reviewed for normal variations of rib.In our
study of 1000 radiographs (Male 652 and female 348), there are 10 cervical ribs, 5 bid ribs, 16 cases of hypertrophied transverse process and 3
fused rib. Thus in conclusion,the knowledge of incidence of normal anatomical variations of ribs and their appearance in a given population is
important for radiologist as it avoids any misinterpretation of these relatively normal variants and signals a possibility of neurovascular
compression if clinically relevant.
Chemical Composition and Quality Attributes of Meat from West African Dwarf Goats Fed some Browse Species Supplemented with a Concentrate Diet
Authors: J.O Ocheja, , B Yahaya, , O.A Bukola, , G,F Egbunu, , M Amidu, , J.N Effienokwu,
Published: February 2022

Twenty (20) yearling west African dwarf goats were used in a study to determine the effects of some browse plants and a supplement diet on the chemical composition and some quality attributes of meat obtained from the goats The experiment lasted for 63 days after an adjustment period of 7 days, the goats were served water ad Libitum. Gmelina (T1), Tamarind (T2), Neem (T3) and Teak (T4) after wilting for 24 hours were fed at 300g/goat/day 2 hours before the concentrate. The supplement was fed at 100g /goat/day. At the end of the feeding trial three (3) goats from each treatment were slaughtered, bled, eviscerated and dressed and there after 60g of meat were cut from the thigh of each of the slaughtered goats and used for the determination of their chemical composition and quality attributes. The experimental design was a completely randomized design , significant means were separated using SPSS version 23.0, 2015 edition, samples of the meat, concentrate diet and the browse plants were analyzed for their proximate composition using the methods outlined by AOAC(2000). There were no significant (P<0.05) differences in the values for daily concentrate intake, ash, moisture, pHi and pHu. Total daily feed intake ranged from 252.50 – 386.00g, and were significantly (P<0.05) different. Fat content values ranged from 4.45 – 10.05%, and were significantly (P>0.05) different protein content values had a range of 18.40 – 23.15% and showed significant (P<0.05) differences values for drip loss, cooking losses, initial and ultimate pH were all significantly (P>0.05) different. The drip loss values ranged from 5.20 – 8.20%, while the cooking loss values were 18.00 – 23.75%, values for both parameters were significantly (P<0.05) different It was concluded that Gmelina (T1) produced goat meat with the best nutrients and quality parameters. Gmelina (T1) at 300g/goat /day as well as bambara nut waste and cereal spent grains based supplement diet were therefore recommended for feeding..
Left Para duodenal Hernia: Case Report of Rare Cause of Small Bowel Obstruction
Authors: Dhiman Dr. Ashish , Kumar Dr. Jeevan , Kumar Dr. Satish , Sood Dr. Prateek
Published: February 2022

Para duodenal hernia [PDH], a rare congenital anomaly, is a type of internal hernia which occurs due to a defect in the reduction and rotation of the midgut. We present the case of a 32-year-old female patient presented with a seven-day history of generalized intermittent colicky abdominal pain accompanied by multiple episodes of bilious vomiting. She was otherwise healthy and had no history of previous abdominal operations. Computed tomography scan of the abdomen demonstrated sac-like clustered small bowel loops noted in the left upper quadrant, in the anterior para-renal space, consistent with the diagnosis of left Para duodenal hernia. Exploratory Laparotomy for the repair of the hernia was planned. The jejunal loops had herniated through the fossa of Waldeyer. Reduction of hernia contents and excision of the hernia sac was carried out. The patient tolerated the procedure without complications, and she was asymptomatic in the follow-up visit. This case sheds light on the importance of considering the diagnosis of left Para duodenal hernia in patients with recurrent abdominal pain, particularly among those who have not undergone abdominal surgery previously.
Chronicity of Hepatotoxicity: A Review
Authors: Bansal Dr. Lalita , Dhiman Dr. Ashish
Published: February 2022

Hepatotoxicity is the damage or liver harm as a result of publicity to drugs; it's far an detrimental drug response that can be unusual however serious. The hepatic damage may be categorised into hepatocellular, cholestatic and mixed, as a result of boom in alanine aminotransferase and alkaline phosphatase than top restrict of normal. The danger elements encompass idiosyncrasy, age, gender, and alcohol consumption, concomitant use of different drugs, preceding or underlying liver disease, genetic and environmental elements. Liver toxicity manifestations are usually followed with the aid of using nonspecific signs consisting of belly pain, jaundice, fever, nausea, vomiting, diarrhea, pruritus and rash. The review gives brief illustration about liver associated injury along with role of antioxidant in oxidative stress.