bluuebunny/crossref_metadata_2025 huggingface dataset:
Sparse planar arrays for azimuth and elevation using experimental data
Authors: Nannuru Santosh , Gerstoft Peter , Ping Guoli , Fernandez-Grande Efren
Published: January 2021

Sparse arrays are special geometrical arrangements of sensors which overcome some of the drawbacks associated with dense uniform arrays and require fewer sensors. For direction finding applications, sparse arrays with the same number of sensors can resolve more sources while providing higher resolution than a dense uniform array. This has been verified numerically and with real data for one-dimensional microphone arrays. In this study the use of nested and co-prime arrays is examined with sparse Bayesian learning (SBL), which is a compressive sensing algorithm, for estimating sparse vectors and support. SBL is an iterative parameter estimation method and can process multiple snapshots as well as multiple frequency data within its Bayesian framework. A multi-frequency variant of SBL is proposed, which accounts for non-flat frequency spectra of the sources. Experimental validation of azimuth and elevation [two-dimensional (2D)] direction-of-arrival (DOA)estimation are provided using sparse arrays and real data acquired in an anechoic chamber with a rectangular array. Both co-prime and nested arrays are obtained by sampling this rectangular array. The SBL method is compared with conventional beamforming and multiple signal classification for 2D DOA estimation of experimental data.
Are Changes in Walking for Transportation in Brazilian Older Adults Associated With Attributes of the Neighborhood Environment?
Authors: de Paiva Neto Francisco Timbó , Arins Gabriel Claudino Budal , d’Orsi Eleonora , Rech Cassiano Ricardo
Published: January 2021

This study aims to examine the association between neighborhood environment attributes and changes in walking for transportation among older adults. Longitudinal analysis was performed considering a population-based study (EpiFloripa Idoso), carried out in 2009–2010 with follow-up in 2013–2014. Changes in walking, obtained with the International Physical Activity Questionnaire during both waves were associated with data from the environment perception, evaluated using individual items from the Neighborhood Environment Walkability Scale (baseline only) performing multinomial logistic regression. A total of 1,162 older adults (65.2% women, mean age = 73.7 years) participated. Those who reported the presence of parks and squares (OR = 2.44, 95% confidence interval [CI; 1.70, 3.51]), sidewalks (OR = 1.66, 95% CI [1.03, 2.70]), crosswalks (OR = 1.69, 95% CI [1.05, 2.72]), illuminated streets (OR = 2.80, 95% CI [1.24, 6.33]), and safety for day walks (OR = 1.93, 95% CI [1.14, 3.24]) were more likely to remain active or become active when commuting (≥150 min/week). Older adults are more active in neighborhoods that present more favorable attributes regarding walking for transportation.
Fifteen-minute consultation: The efficient investigation of infantile and childhood epileptic encephalopathies in the era of modern genomics
Authors: Perry Luke Daniel , Hogg Sarah Louise , Bowdin Sarah , Ambegaonkar Gautam , Parker Alasdair PJ
Published: January 2021

The investigation of children presenting with infantile and childhood epileptic encephalopathies (ICEE) is challenging due to diverse aetiologies, overlapping phenotypes and the relatively low diagnostic yield of MRI, electroencephalography (EEG) and biochemical investigations. Careful history and thorough examination remain essential as these may identify an acquired cause or indicate more targeted investigation for a genetic disorder. Whole exome sequencing (WES) with analysis of a panel of candidate epilepsy genes has increased the diagnostic yield. Whole genome sequencing (WGS), particularly as a trio with both parents’ DNA, is likely to supersede WES. Modern genomic investigation impacts on the timing and necessity of other testing. We propose a structured approach for children presenting with ICEE where there is diagnostic uncertainty, emphasising the importance of WGS or, if unavailable, WES early in the investigative process. We note the importance of expert review of all investigations, including radiology, neurophysiology and biochemistry, to confirm the technique used was appropriate as well as the results. It is essential to counsel families on the risks associated with the procedures, the yield of the procedures, findings that are difficult to interpret and implication of ‘negative’ results. Where children remain without a diagnosis despite comprehensive investigation, we note the importance of ongoing multidisciplinary care.
Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature
Authors: Soni Subhash , Elhence Poonam , Varshney Vaibhav Kumar , Suman Sunita
Published: January 2021

Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.
High-dose methotrexate-induced reversible grade 4 hyperbilirubinaemia and transaminitis in an adolescent with Burkitt Leukaemia
Authors: Khera Sanjeev , Ranjan Randhir , Ramachandran Sateesh , Beriwal Ajay
Published: January 2021

Symptomatic drug-induced liver injury (DILI) is an uncommon problem. Direct DILI is dose-related, predictable with short latency (hour to days) and is generally associated with transient and reversible transaminitis without jaundice. Antimetabolites including methotrexate are a common cause for direct DILI. Hepatotoxicity associated with high-dose methotrexate (HD-MTX) is generally transient and includes reversible elevation of transaminase in up to 60% and associated hyperbilirubinaemia (≤grade 2) in 25% of courses and therefore is of no clinical significance. Severe grades of DILI with HD-MTX (grade ≥4) are extremely rare. We describe an adolescent with Burkitt leukaemia who had reversible grade 4 DILI including hyperbilirubinaemia postfirst course of HD-MTX. Rechallenge with two-third dose of HD-MTX in subsequent chemotherapeutic cycle did not cause recurrence of DILI.
When fever is more than infection: two cases of vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS)
Authors: Cox Mitchell , Paviour Sophie , Gregory Sophie , Chew Rusheng
Published: January 2021

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, but serious systemic hypersensitivity reaction associated with a range of medications. We present two cases of vancomycin-induced DRESS, which occurred simultaneously in the orthopaedic ward in an outer metropolitan hospital. These cases demonstrate the complexity in the diagnosis and management of this inflammatory syndrome on the background of known infection as well as evidence for linezolid as an alternative to vancomycin. The first case was managed conservatively, but developed progressive renal and liver injury along with demonstrated cytomegalovirus reactivation and recurrent colitis, and was eventually palliated. The second was commenced on intravenous glucocorticoids and achieved remission, although had ongoing renal dysfunction at the time of discharge from outpatient follow-up.
Newborn infant with congenital lentigines as a manifestation of Carney Complex
Authors: Bilkhu Amarpal Singh , Sunderesan Raju
Published: January 2021

Carney Complex (CNC) is a rare syndrome characterised by skin pigmentation, endocrine over activity and myxomas, with the median age of detection being 20 years. We present a case of CNC diagnosed in infancy after being noted to have multiple lentigines over his face, abdomen, back and thighs at birth. We consider the differential diagnoses of similar cutaneous presentations in the well neonate and review the prognosis and suggested surveillance of patients with CNC.
COVID-19 as the cause of thrombosis: recognising COVID-19 infection in apparently asymptomatic patients
Authors: Varner Kyle B , Cox Emily J
Published: January 2021

COVID-19 has serious thrombotic complications in critically ill patients; however, thrombus is not a typical presenting symptom. This case report describes a patient with no respiratory symptoms who presented to the emergency department with abdominal pain. The pain was attributed to renal thrombosis, but the patient was found to have no risk factors for thrombotic disease and subsequent hypercoagulable work-up was unremarkable. Pulmonary manifestations of COVID-19 infection were detected incidentally on the abdominal CT scan and confirmed via PCR test. The patient was isolated and went on to develop mild respiratory failure secondary to COVID-19 infection. This case suggests that unexplained thrombus in otherwise asymptomatic patients can be a direct result of COVID-19 infection, and serves as a call to action for emergency department clinicians to treat unexplained thrombotic events as evidence of COVID-19.
Blockade of AIM2 inflammasome or α1-AR ameliorates IL-1β release and macrophage-mediated immunosuppression induced by CAR-T treatment
Authors: Liu Dan , Xu Xiyue , Dai Yulian , Zhao Xuan , Bao Shunshun , Ma Wen , Zha Li , Liu Shuci , Liu Yuchen , Zheng Junnian , Shi Ming
Published: January 2021

Background

Interleukin (IL) 1 released from monocytes/macrophages is one of the critical determinants in mediating the adverse events of chimeric antigen receptor T cell (CAR-T) therapy, including cytokine release syndrome and neurotoxicity. However, the molecular mechanisms of IL-1 production during CAR-T therapy remain unknown.

Methods

The roles of AIM2 and α1-adrenergic receptor (α1-AR) in CAR-T treatment-induced IL-1β release were evaluated by gene silencing, agonist or antagonist treatment. The phenotype switch of macrophages in response to CAR-T treatment was analyzed concerning cytotoxicity of CAR-T cells and proliferation of activated T cells.

Results

This study provided the experimental evidence that CAR-T treatment-induced activation of AIM2 inflammasome of macrophages resulted in the release of bioactive IL-1β. CAR-T treatment-induced α1-AR-mediated adrenergic signaling augmented the priming of AIM2 inflammasome by enhancing IL-1β mRNA and AIM2 expression. Meanwhile, tumor cell DNA release triggered by CAR-T treatment potentiated the activation of AIM2 inflammasome in macrophages. Interestingly, an apparent phenotypic switch in macrophages occurred after interacting with CAR-T/tumor cells, which greatly inhibited the cytotoxicity of CAR-T cells and proliferation of activated T cells through upregulation of programmed cell death-ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase (IDO) in the macrophages. Blockade of AIM2 inflammasome or α1-AR reversed the upregulation of PD-L1 and IDO and the phenotypic switch of the macrophages.

Conclusion

Our study implicates that CAR-T therapy combined with the blockade of AIM2 inflammasome or α1-AR may relieve IL-1β-related toxic side effects of CAR-T therapy and ensure antitumor effects of the treatment.
Operational based stochastic cluster regression-based modeling for predicting condition rating of highway tunnels
Authors: Hasan Sahar , Elwakil Emad
Published: January 2021

Despite the higher capital costs of tunnels and supplementary cost of maintenance, fewer deterioration models have been built compared with other highway components. Most of these models were limited to structural defects, not operational conditions. Moreover, there are inherent subjectivity and inaccuracy of the developed models, which may affect the maintenance process. The aim of this research and proposed contribution are investigating and modeling the impact of explanatory variables and non-periodic maintenance effect on highway tunnel condition. The stochastic regression analysis has been conducted to come out with a realistic tunnel condition through the Monte Carlo simulation methodology. The research methodology consists of three phases: cluster analysis, regression modeling, and stochastic analysis. A dataset of 473 highway tunnels along 41 American states from the National Tunnels Inventory (NTI) has been used. Nine models have been developed with a high coefficient of determination (R2 = 90.8%). The obtained results and the models could help advance the development of tunnel deterioration models from a management perspective, not only from the structural view. The developed models help highway authorities to prioritize the maintenance and objectively make informed investment decisions based on the historical data. This research has come as a response to the significant problems facing the highway authorities regarding tunnels and asset management.
Demographical and morphological differences among coyotes (Canis latrans) relative to sampling method
Authors: Shutler Dave , Priest Jenna M. , Stewart Donald T. , Boudreau Michael
Published: January 2021

Collection methods can be biased, leading to misperceptions of population composition. We tested if collection method (footholds, snares, and shooting) gave different perceptions of demography or morphology of 3539 eastern coyotes (Canis latrans Say, 1823). We found no differences in sex ratios of animals among methods, but did find some evidence that younger, lighter, and smaller animals were more likely to be collected by footholds than with snares. Female reproductive histories (placental scars) did not differ among methods. In a subsample of 232 animals, we found no evidence of differences in helminth parasitism relative to collection method. Overall, our large sample for the non-parasite analyses facilitated finding statistical significance; the biological implications hinge on the precision required in estimating population composition and the focal characteristics being compared. For example, mass was 5.3% lower for coyotes caught with footholds versus snares and 10.4% lower for coyotes caught with footholds versus being shot, whereas linear trait measurements of coyotes caught with footholds were generally smaller by at most 4.5% compared with other methods (broadly consistent with linear versus volumetric measurements). Our study provides important baseline information for making inferences about populations of coyotes (and other species) sampled using only a single collection method.
Subgraph-based Strong Menger Connectivity of Hypercube and Exchanged Hypercube
Authors: Wang Yihong , Lin Cheng-Kuan , Zhou Shuming , Tian Tao
Published: January 2021

Large scale multiprocessor systems or multicomputer systems, taking interconnection networks as underlying topologies, have been widely used in the big data era. Fault tolerance is becoming an essential attribute in multiprocessor systems as the number of processors is getting larger. A connected graph [Formula: see text] is called strong Menger (edge) connected if, for any two distinct vertices [Formula: see text] and [Formula: see text], there are [Formula: see text] vertex (edge)-disjoint paths between them. Exchanged hypercube [Formula: see text], as a variant of hypercube [Formula: see text], remains lots of preferable fault tolerant properties of hypercube. In this paper, we show that [Formula: see text] [Formula: see text] and [Formula: see text] [Formula: see text] are strong Menger (edge) connected, respectively. Moreover, as a by-product, for dual cube [Formula: see text], one popular generalization of hypercube, [Formula: see text] is also showed to be strong Menger (edge) connected, where [Formula: see text].
Bi3O4Br nanoplates as an efficient piezo-photocatalyst for organic dye degradation
Authors: Zhou Qin , Jiang Jing
Published: January 2021

The layered Bi3O4Br nanoplates were synthesized through a simple calcination process, which can simultaneously harvest visible light and ultrasonic vibration to realize the effective piezo-photocatalysis. The piezo-photocatalysis over the Bi3O4Br leads to a great enhancement in catalytic efficiency with respect to the pure photocatalysis or piezocatalysis. The apparent rate constant of piezo-photocatalysis for the degradation of MO achieves to be 0.008 min[Formula: see text], which is 5.20 and 1.51 times as high as the individual piezocatalysis and photocatalysis, respectively. This enhancement would be attributed to the built-in piezoelectric field induced by ultrasonic vibration facilitating the separation of charge carriers in photoexcited Bi3O4Br.
Baleen Analytics
Authors: Helland Pat
Published: January 2021

Data analytics hoovers up anything it can find and we are finding patterns and insights that weren't available before, with implications for both data analytics and for messaging between services and microservices. It seems that a pretty good understanding among many different sources allows more flexibility and interconnectivity. Increasingly, flexibility dominates perfection.
Signaling Microdomains in the Spotlight: Visualizing Compartmentalized Signaling Using Genetically Encoded Fluorescent Biosensors
Authors: Zhang Jin-Fan , Mehta Sohum , Zhang Jin
Published: January 2021

How cells muster a network of interlinking signaling pathways to faithfully convert diverse external cues to specific functional outcomes remains a central question in biology. Through their ability to convert dynamic biochemical activities to rapid and precise optical readouts, genetically encoded fluorescent biosensors have become instrumental in unraveling the molecular logic controlling the specificity of intracellular signaling. In this review, we discuss how the use of genetically encoded fluorescent biosensors to visualize dynamic signaling events within their native cellular context is elucidating the different strategies employed by cells to organize signaling activities into discrete compartments, or signaling microdomains, to ensure functional specificity.
Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats
Authors: Gohar Eman Y. , Almutlaq Rawan N. , Daugherty Elizabeth M. , Butt Maryam K. , Jin Chunhua , Pollock Jennifer S. , Pollock David M. , De Miguel Carmen
Published: January 2021

Recent evidence indicates a crucial role for G protein-coupled estrogen receptor 1 (GPER1) in the maintenance of cardiovascular and kidney health in females. The current study tested whether GPER1 activation ameliorates hypertension and kidney damage in female Dahl salt-sensitive (SS) rats fed a high-salt (HS) diet. Adult female rats were implanted with telemetry transmitters for monitoring blood pressure and osmotic minipumps releasing G1 (selective GPER1 agonist, 400 μg/kg/day ip) or vehicle. Two weeks after pump implantation, rats were shifted from a normal-salt (NS) diet (0.4% NaCl) to a matched HS diet (4.0% NaCl) for 2 wk. Twenty-four hour urine samples were collected during both diet periods and urinary markers of kidney injury were assessed. Histological assessment of kidney injury was conducted after the 2-wk HS diet period. Compared with values during the NS diet, 24-h mean arterial pressure markedly increased in response to HS, reaching similar values in vehicle-treated and G1-treated rats. HS also significantly increased urinary excretion of protein, albumin, nephrin (podocyte damage marker), and KIM-1 (proximal tubule injury marker) in vehicle-treated rats. Importantly, G1 treatment prevented the HS-induced proteinuria, albuminuria, and increase in KIM-1 excretion but not nephrinuria. Histological analysis revealed that HS-induced glomerular damage did not differ between groups. However, G1 treatment preserved proximal tubule brush-border integrity in HS-fed rats. Collectively, our data suggest that GPER1 activation protects against HS-induced proteinuria and albuminuria in female Dahl SS rats by preserving proximal tubule brush-border integrity in a blood pressure-independent manner.
Study on the Calculation Method of the Diffusion Range of Grouting Slurry for a High‐speed Railway Ballastless Track Subgrade
Authors: Yang Changwei , Guo Jinhao , Wei Shaowei , Zhang Liang , Li Sifeng , Liu Yang
Published: January 2021

Grouting engineering is the most convenient and quick way to deal with postconstruction settlement. Based on the investigation of the Beijing Shenyang high‐speed railway in the early stage, the microdestructive force of grout on the soil mass in the process of grouting with the method of fluid solid coupling theory was analyzed. The numerical simulation results show that, in the grouting process, the greater the grouting pressure, the wider the diffusion range of the slurry and the greater the damage to the microscopic contact force of the slurry to the soil; in addition, when the grouting pressure is below 0.15 MPa, the diffusion form of the slurry in the soil is osmotic grouting; when the pressure is about 0.3 MPa, the diffusion form of the slurry in the soil is compacted grouting; on the basis of the simulation results, a deeper research is carried out, and the calculation formula of the slurry diffusion curve is obtained. It fills in the blank of the theoretical study of the slurry diffusion curve. In this paper, the diffusion formula of grouting slurry can be used in the theoretical study of clay grouting, and it can be used as a reference for practical engineering.
Normative and Equated Data of the Original and Basic Versions of the Montreal Cognitive Assessment among Community Dwelling Saudi Arabians
Authors: Muayqil Taim A. , Alamri Nada K. , Alqahtani Awyshah M. , Julaidan Sarah S. , Alsuhaibani Raya , Nafisah Ibrahim , Alkeridy Walid A. , Aljafen Bandar N. , Alanazy Mohammed H.
Published: January 2021

Introduction. Currently, there are standard and basic versions of the MoCA, the latter designed for those with lower educational achievements. Community-based normative data on these versions of the MoCA from Arabic populations are deficient, and there is little data demonstrating how both scales perform in comparison. We aim to obtain normative performances from both versions and equate the measures of both scales. Methods. Community-based recruitment of

healthy
 
volunteers
≥
18

years of age. Participants underwent testing with both versions. Demographic data was collected with regard to age, gender, years of education, diabetes, and hypertension. Regression analysis was performed to determine significance of variables, and the circle-arc equating method was used to equate the two scores from each scale. Results. 311 participants were included in the study. The mean (sd) age was 45.8 (15.96), females were 184 (59.16%), and the duration of education was 12.7 (5.67) years. The mean scores on the MoCA-A and MoCA-B were 21.47 (4.53) and 24.37 (4.71) (

P
<
0.0001

), respectively. Multivariate regression showed significance of age and years of education in both versions (both variables with

P
<
0.0001

). Correlation coefficient between the two scales was 0.77 (

P
<
0.0001

). The largest equated difference between both MoCA versions was four points in those scoring from 10-20 on the MoCA-A. Conclusion. We present normative data from a large Saudi Arabian community-based sample with two different MoCA tests, and an equating graph is presented to determine the corresponding expected performance between the two scales.
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway
Authors: Zhang Shuo , Zhang Rong , Qiao Pengyan , Ma Xiaocao , Lu Rongjian , Wang Feifan , Li Chuanjie , E Lingling , Liu Hongchen
Published: January 2021

Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metformin on DPSC senescence. Young and aging DPSCs were isolated from freshly extracted human teeth. Flow cytometry confirmed that DPSCs expressed characteristic surface antigen markers of mesenchymal stem cells (MSCs). Cell Counting Kit-8 (CCK-8) assay showed that a concentration of 100 μM metformin produced the highest increase in the proliferation of DPSCs. Metformin inhibited senescence in DPSCs as evidenced by senescence-associated β-galactosidase (SA-β-gal) staining and the expression levels of senescence-associated proteins. Additionally, metformin significantly suppressed microRNA-34a-3p (miR-34a-3p) expression, elevated calcium-binding protein 39 (CAB39) expression, and activated the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway. Dual-luciferase reporter assay confirmed that CAB39 is a direct target for miR-34a-3p. Furthermore, transfection of miR-34a-3p mimics promoted the senescence of DPSCs, while metformin treatment or Lenti-CAB39 transfection inhibited cellular senescence. In conclusion, these results indicated that metformin could alleviate the senescence of DPSCs by downregulating miR-34a-3p and upregulating CAB39 through the AMPK/mTOR signaling pathway. This study elucidates on the inhibitory effect of metformin on DPSC senescence and its potential as a therapeutic target for senescence treatment.
A Cross-Sectional Study on Balance Deficits and Gait Deviations in COPD Patients
Authors: Jirange Priyanka , Vaishali K. , Sinha Mukesh Kumar , Bairapareddy Kalyana Chakravarthy , Alaparthi Gopala Krishna
Published: January 2021

Background. The gait abnormalities were linked to the balance deficits in the previous studies. However, the deviations in the gait parameters in COPD are currently not known. The study aims to compare gait parameters, static and dynamic balance, and risk of falls in COPD with those in non-COPD individuals. Method. Fourty-two patients with COPD aged 45 years and gender-matched control subjects were included in the study. Gait parameters were assessed by Win-Track gait analyzer, the static balance was assessed by posturography, and the dynamic balance was assessed by the time up and go test. The fear of falls was assessed by Falls Efficacy Scale. Results. COPD individuals had decreased static and dynamic balance as assessed by posturography (

p
<
0.05

) and TUG (

p
<
0.01

), respectively. A significant difference in swing duration (

p
=
0.004

) and also increased risk of falls (

p
<
0.01

) was observed in COPD patients as compared to non-COPD individuals. Conclusion. COPD individuals have increased swing duration, reduced static and dynamic balance, and increased fear of falls as compared to non-COPD individuals.
Assessment of Nutritional, Technological, and Commercial Apricot Quality Criteria of the Moroccan Cultivar “Maoui” Compared to Introduced Spanish Cultivars “Canino” and “Delpatriarca” towards Suitable Valorization
Authors: Ayour Jamal , Alahyane Abderrahim , Harrak Hasnaâ , Neffa Mounsef , Taourirte Moha , Benichou Mohamed
Published: January 2021

Apricot is among the most important fruits in Morocco. This study aimed to determine the main physical, physicochemical, and biochemical quality criteria of three principal apricot cultivars in Morocco, namely, “Maoui,” “Canino,” and “Delpatriarca.” Different physicochemical and biochemical methods have been improved and adapted for the assessment of the apricot’s quality. Fruit of “Canino” has shown a good organoleptic quality due to interesting biometrics, richness of carotenoids (up to 113.67 μg of β-carotene g−1 of fresh weight (FW)), and an important content of soluble solids (SS) that reached 17.20 °Bx. “Delpatriarca” is rich in organic acids (27.35 g/kg FW for total acids) while “Maoui” has high water content (83.77%) and a SS content of 16.03 °Bx. The association of the total acidity and soluble solids determination with the use of the HPLC for determining the organic acids was very practical and effective in determining the organoleptic quality of the fruit. High correlations were detected between several attributes. In addition, an important relationship between total carotenoids concentration and color parameters (L

∗

a

∗

b

∗

) demonstrated that these parameters are good for apricot quality and ripening indices. The obtained results also revealed the presence of a high variability among the quality criteria of the three apricot cultivars. These characteristics could be useful for promoting the consumption of the “Maoui” as fresh fruits and the use of “Canino” and “Delpatriarca” for industry derivatives products. The results could also be useful for new apricot breeding program among different eco-geographical groups of the Mediterranean region.
A Nonstationary Ternary 4-Point Shape-Preserving Subdivision Scheme
Authors: Tan Jieqing , Tong Guangyue
Published: January 2021

This paper uses the continued fraction technique to construct a nonstationary 4-point ternary interpolatory subdivision scheme, which provides the user with a tension parameter that effectively handles cusps compared with a stationary 4-point ternary interpolatory subdivision scheme. Then, the continuous nonstationary 4-point ternary scheme is analyzed, and the limit curve is at least

C

2

-continuous. Furthermore, the monotonicity preservation and convexity preservation are proved.
Identified GNGT1 and NMU as Combined Diagnosis Biomarker of Non-Small-Cell Lung Cancer Utilizing Bioinformatics and Logistic Regression
Authors: Zhang Jia-Jia , Hong Jiang , Ma Yu-Shui , Shi Yi , Zhang Dan-Dan , Yang Xiao-Li , Jia Cheng-You , Yin Yu-Zhen , Jiang Geng-Xi , Fu Da , Yu Fei
Published: January 2021

Non-small-cell lung cancer (NSCLC) is one of the most devastating diseases worldwide. The study is aimed at identifying reliable prognostic biomarkers and to improve understanding of cancer initiation and progression mechanisms. RNA-Seq data were downloaded from The Cancer Genome Atlas (TCGA) database. Subsequently, comprehensive bioinformatics analysis incorporating gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and the protein-protein interaction (PPI) network was conducted to identify differentially expressed genes (DEGs) closely associated with NSCLC. Eight hub genes were screened out using Molecular Complex Detection (MCODE) and cytoHubba. The prognostic and diagnostic values of the hub genes were further confirmed by survival analysis and receiver operating characteristic (ROC) curve analysis. Hub genes were validated by other datasets, such as the Oncomine, Human Protein Atlas, and cBioPortal databases. Ultimately, logistic regression analysis was conducted to evaluate the diagnostic potential of the two identified biomarkers. Screening removed 1,411 DEGs, including 1,362 upregulated and 49 downregulated genes. Pathway enrichment analysis of the DEGs examined the Ras signaling pathway, alcoholism, and other factors. Ultimately, eight prioritized genes (GNGT1, GNG4, NMU, GCG, TAC1, GAST, GCGR1, and NPSR1) were identified as hub genes. High hub gene expression was significantly associated with worse overall survival in patients with NSCLC. The ROC curves showed that these hub genes had diagnostic value. The mRNA expressions of GNGT1 and NMU were low in the Oncomine database. Their protein expressions and genetic alterations were also revealed. Finally, logistic regression analysis indicated that combining the two biomarkers substantially improved the ability to discriminate NSCLC. GNGT1 and NMU identified in the current study may empower further discovery of the molecular mechanisms underlying NSCLC’s initiation and progression.
Aortic Arch Replacement without Deep Hypothermic Circulatory Arrest
Authors: Bakhutashvili Zviad , Janelidze Lia , Beria Kakhaber , Matikashvili Simon , Limonjiani Eduard
Published: January 2021

A 60-year-old man presented with a thoracic aortic aneurysm without rupture accompanied by severe nonrheumatic aortic valve insufficiency and unstable angina. Surgery was performed and included several steps: (1) resection and reconstruction of ascending aorta and aortic arch using a tube graft, (2) replacement of aortic valve using a biological prosthesis, and (3) coronary artery bypass grafting was performed with two distal anastomoses. All of these procedures were performed with total cardiopulmonary bypass without deep hypothermic circulatory arrest under conditions of moderate hypothermia using dual concurrent cannulation of the subclavian and femoral arteries.
Adaptive Physical Layer Selection for Bluetooth 5: Measurements and Simulations
Authors: Sheikh Muhammad Usman , Badihi Behnam , Ruttik Kalle , Jäntti Riku
Published: January 2021

The main target of this article is to propose a simple Received Signal Strength Indicator‐ (RSSI‐) based adaptive Physical Layer (PHY) selection approach for Bluetooth Low Energy 5.0 (BLE 5) and compare the performance of adaptive PHY selection with the performance of individual PHY. This article also validates the simulation results acquired from the in‐house developed Ray Tracing (RT) tool with the BLE 5 measurements conducted in a corridor of the TUAS building, Aalto University. The performance metrics considered for the analysis are RSSI, throughput, and outage ratio. The impact of different transmission power on BLE 5 is also analyzed. The obtained simulation results indicate a Root Mean Square Error (RMSE) of about 4.6 dB between the measured and the simulated RSSI at 2.4 GHz frequency. By investigating these results, an adaptive PHY selection algorithm is proposed in this article. The adaptive PHY selection approach enhances the mean throughput of the system and improves the outage ratio as well. In the light of acquired results, the adaptive PHY selection scheme shows significant performance gain and is found more beneficial in the case of an environment with mixed RSSI samples, i.e., a mix of low and high RSSI values.
Dispersed Computing for Tactical Edge in Future Wars: Vision, Architecture, and Challenges
Authors: Yang Haigen , Li Gang , Sun GuiYing , Chen JinXiang , Meng Xiangxin , Yu HongYan , Xu Wenting , Qu Qiang , Ying Xiaokun
Published: January 2021

In the future, the tactical edge is far away from the command center, the resources of communication and computing are limited, and the battlefield situation is changing rapidly, which leads to the weak connection and fast changes of network topology in a harsh and complex battlefield environment. Thus, to meet the needs of communication and computing to build a new generation of computing architecture for real‐time sharing and service collaboration of tactical edge resources to win the future war, the dispersed computing (DCOMP) seeks a new solution to satisfy the requirements of fast and efficient sensing, transmission, integrating, scheduling, and processing of various information in the tactical edge. Through the research of a traditional computing paradigm of mobile cloud computing (MCC), fog computing (FC), mobile edge computing (MEC), mobile ad hoc network (MANET), etc., it can be found that these computations have difficulty in meeting the high changing and complex battlefield environment and we propose a novel architecture of DCOMP to build a scalable, extensible, and robust decision‐making system, to realize powerful and secure communication, computing, storage, and information processing capabilities for the tactical edge. We illustrate the fundamental principles of building a network model, channel allocation, and forwarding control mechanism of the network architecture for DCOMP called DANET and then design a new architecture, programming model, task awareness, and computing scheduling for DCOMP. Finally, we discuss the main requirements and challenges of DCOMP in future wars.
The Beekeeping State and Inventory of Mellifero-Medicinal Plants in the North-Central of Morocco
Authors: Bakour Meryem , Laaroussi Hassan , El menyiy Nawal , Elaraj Tarik , El ghouizi Asmae , Lyoussi Badiaa
Published: January 2021

This study aims to determine the diversity of melliferous plants and to recognize the state of beekeeping in the Fez-Meknes region in Morocco. We conducted a questionnaire for beekeepers that set up their hives in the prefectures and provinces of the region, and we have studied the pharmacological evidence of the most preferred plants by beekeepers to assess its medicinal values. The results indicate that honey, bee pollen, bee bread, royal jelly, propolis, bee wax, bee venom, and bee queens are produced in this region with different percentages, and 102 plants belonging to 32 families were obtained in the inventory of melliferous plants; the most represented families were Asteraceae and Lamiaceae (13.73% each) followed by Rosaceae (8.82%). Among these 102 plants identified, 79 plants provide nectar and pollen for bees, 16 plants provide only pollen, 3 plants provide only nectar, 35 plants are resinous, and 6 plants provide honeydew for bees. The outcome of this study will contribute to the valuation of melliferous plants and help to establish a practical guide for the development of the beekeeping sector as an agricultural economic approach.
CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia
Authors: Ding Husheng , Vincelette Nicole D. , McGehee Cordelia D. , Kohorst Mira A. , Koh Brian D. , Venkatachalam Annapoorna , Meng X. Wei , Schneider Paula A. , Flatten Karen S. , Peterson Kevin L. , Correia Cristina , Lee Sun-Hee , Patnaik Mrinal , Webster Jonathan A. , Ghiaur Gabriel , Smith B. Douglas , Karp Judith E. , Pratz Keith W. , Li Hu , Karnitz Larry M. , Kaufmann Scott H.
Published: January 2021

Although inhibitors of the kinases CHK1, ATR, and WEE1 are undergoing clinical testing, it remains unclear how these three classes of agents kill susceptible cells and whether they utilize the same cytotoxic mechanism. Here we observed that CHK1 inhibition induces apoptosis in a subset of acute leukemia cell lines in vitro, including TP53-null acute myeloid leukemia (AML) and BCR/ABL–positive acute lymphoid leukemia (ALL), and inhibits leukemic colony formation in clinical AML samples ex vivo. In further studies, downregulation or inhibition of CHK1 triggered signaling in sensitive human acute leukemia cell lines that involved CDK2 activation followed by AP1-dependent TNF transactivation, TNFα production, and engagement of a TNFR1- and BID-dependent apoptotic pathway. AML lines that were intrinsically resistant to CHK1 inhibition exhibited high CHK1 expression and were sensitized by CHK1 downregulation. Signaling through this same CDK2–AP1–TNF cytotoxic pathway was also initiated by ATR or WEE1 inhibitors in vitro and during CHK1 inhibitor treatment of AML xenografts in vivo. Collectively, these observations not only identify new contributors to the antileukemic cell action of CHK1, ATR, and WEE1 inhibitors, but also delineate a previously undescribed pathway leading from aberrant CDK2 activation to death ligand–induced killing that can potentially be exploited for acute leukemia treatment.

Significance:

This study demonstrates that replication checkpoint inhibitors can kill AML cells through a pathway involving AP1-mediated TNF gene activation and subsequent TP53-independent, TNFα-induced apoptosis, which can potentially be exploited clinically.
Intralymphatic Histiocytosis: An Unusual Presentation
Authors: Blackwell Timothy J. , Ingersoll Zachary , Blackwell Martin
Published: January 2021

Intralymphatic histiocytosis (ILH) is a rare cutaneous condition initially described in 1994 by O’Grady et al. It often appears as a red to violaceous, livedoid patch or plaque usually on the extremities. We present a 71-year-old female with a history of psoriasis, 50 pack years smoking and recent Legionnaires disease who came to us complaining of a red to violaceous, blanching, edematous, mildly tender lesion covering the left lower lip and extending to the chin and anterior neck. After multiple biopsies, ILH was confirmed and the patient was initially started on tacrolimus 0.1% ointment b.i.d., but there was no response. Then, she was started on oral pentoxifylline and intermittent topical steroids, as well as continuing the topical tacrolimus. There was again no response, so now she is taking a TNF-ɑ inhibitor as it appears to be a granulomatous process. These ILH cases are very rare and there is limited literature that describes one treatment as a cure. Treatment of ILH is very difficult, but several different therapies have been reported with varying success. If the disease is secondary to an underlying inflammatory disease or malignancy, then treatment of the primary disorder can lead to resolution of the ILH.
Postoperative Endophthalmitis Caused by Cutibacterium (Formerly Propionibacterium) Acnes: Case Series and Review
Authors: Fowler Benjamin J. , Miller Darlene , Yan Xiaohe , Yannuzzi Nicolas A. , Flynn Jr. Harry W.
Published: January 2021

We report the clinical features, treatment strategies and outcomes in a series of patients with infectious endophthalmitis after cataract surgery caused by Cutibacterium acnes (C. acnes), formerly known as Propionibacterium acnes (P. acnes). This retrospective case series includes six eyes of six patients with chronic postoperative endophthalmitis caused by culture-proven C. acnesfrom December 2010 to July 2019 at a University referral center. All patients underwent prior cataract extraction with intraocular lens (CE/IOL) implantation. The mean time between cataract surgery and the microbiologic diagnosis of endophthalmitis was 7.4 ± 5.2 months (range 1.5–17 months). The average time from obtaining the specimen to culture positivity was 7.7 ± 4.4 days (range 3–15 days). Three eyes (50%) presented with hypopyon and three eyes (50%) presented with prominent keratic precipitates without hypopyon. Presenting visual acuity ranged from 20/25 to 2/200. Initial treatments included intravitreal antibiotics alone (n = 2), pars plana vitrectomy (PPV) with partial capsulectomy and intravitreal antibiotics (n = 3), and pars plana vitrectomy with IOL removal and intravitreal antibiotics (n = 1). Follow-up treatments included IOL removal (n = 2), intravitreal antibiotics (n = 1), and topical antibiotics (n = 1). The best-corrected visual acuity at last follow-up was 20/70 or better in all patients. In a literature review, the clinical features and treatment outcomes for all case series of delayed-onset postoperative endophthalmitis caused by C. acnes(n = 120) are listed. A definitive cure (the absence of recurrent inflammation) was achieved in 100% of patients that underwent IOL removal, in 77% of those that underwent PPV/partial capsulectomy and intravitreal antibiotics, and in 18% of cases treated with intravitreal antibiotics alone. Endophthalmitis after CE/IOL caused by C. acnesis characterized by slowly progressive intraocular inflammation and has a protracted course from surgery to microbiologic diagnosis. Visual outcomes are generally favorable, but IOL explantation may be necessary for definitive cure.
Effect of Phenobarbitone on Amplitude-Integrated Electroencephalography in Neonates with Hypoxic-Ischemic Encephalopathy during Hypothermia
Authors: Deshpande Poorva , Jain Amish , McNamara Patrick J.
Published: January 2021

Background: Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has not been well characterized. Objective: To evaluate the effect of phenobarbitone on aEEG in neonates with HIE undergoing TH. Methods: Thirty-five neonates born at ≥350 weeks gestational age (GA), who received phenobarbitone as first-line antiepileptic drug during TH for ≥ Sarnat stage II HIE with aEEG recordings were retrospectively studied. Background pattern, upper and lower margin voltages were characterized for a 30-min period before and 30–60 min after phenobarbitone administration. Primary outcome was presence of severely abnormal aEEG pattern after phenobarbitone administration. Results: Mean (±SD) GA and median birth weight were 38.2 ± 1.9 weeks and 3.1 (2.5–3.9) kg, respectively. Phenobarbitone (10–20 mg/kg), administered at median age 16.8 h, was associated with background pattern worsening in 19/29 (65.5%) cases. Severe background patterns were more prevalent in post- versus pre-phenobarbitone tracings (21/29 [72%] vs. 11/29 [38%]; p = 0.01). Presence of severe pattern versus either continuous normal voltage or discontinuous normal voltage pattern post-phenobarbitone, (20/25 [80%] vs. 3/8 [38%]; p = 0.036) was associated with death or moderate-to-severe injury on MRI brain. Median time to trace recovery, when measurable, was 4 h (45 min–72 h). Conclusions: Phenobarbitone induces significant suppression on aEEG in infants with HIE undergoing TH. Development of severe aEEG background patterns after phenobarbitone may unmask a population at greater risk of abnormal outcome.
Peak In- and Expiratory Flow Revisited: Reliability and Reference Values in Adults
Authors: Hanon Shane , Vanderhelst Eef , Vincken Walter , Schuermans Daniel , Verbanck Sylvia
Published: January 2021

Background: While peak in- and expiratory flow rates offer valuable information for diagnosis and monitoring in respiratory disease, these indices are usually considered too variable to be routinely used for quantification in clinical practice. Objectives: The aim of the study was to obtain reproducible measurements of maximal inspiratory flow rates and to construct reference equations for peak in- and expiratory flows (PIF and PEF). Method: With coaching for maximal effort, 187 healthy Caucasian subjects (20–80 years) performed at least 3 combined forced inspiratory and expiratory manoeuvres, until at least 2 peak inspiratory flow measurements were within 10% of each other. The effect on PIF preceded by a slow expiration instead of a forced expiration and PIF repeatability over 3 different days was also investigated in subgroups. Reference values and limits of normal for PIF, mid-inspiratory flow, and PEF were obtained according to the Lambda-Mu-Sigma statistical method. Results: A valid PIF could be obtained within 3.3 ± 0.6(SD) attempts, resulting in an overall within-test PIF variability of 4.6 ± 3.2(SD)%. A slow instead of a forced expiration prior to forced inspiration resulted in a significant (p < 0.001) but small PIF increase (2.5% on average). Intraclass correlation coefficient for between-day PIF was 0.981 (95% CI: 0.960–0.992). Over the entire age range, inter-subject PIF variability was smaller than in previous reports, and PIF could be predicted based on its determinants gender, age, and height (r2 = 0.53). Conclusions: When adhering to similar criteria for the measurement of effort-dependent portions of inspiratory and expiratory flow-volume curves, performed according to current ATS/ERS standards, it is possible to obtain reproducible PIF and PEF values for use in routine clinical practice.