bluuebunny/crossref_metadata_2025 huggingface dataset:
Third-gradient continua: nonstandard equilibrium equations and selection of work conjugate variables
Authors: Fedele Roberto
Published: July 2022

This paper outlines the variational derivation of the Lagrangian equilibrium equations for the third-gradient materials, stemming from the minimization of the total potential energy functional, and the selection of suitable dual variables to represent the inner work in the Eulerian configuration. Volume, face, edge and wedge contributions were provided through integration by parts of the inner virtual work and by repeated applications of the divergence theorem extended to embedded submanifolds with codimension one and two. Detailed expressions were provided for the contact pressures and the edge loading, revealing the complex dependence on the face normals and on the mean curvature. Relationships were specified among the Lagrangian (hyper-)stress tensors of rank lower or equal to four, and their Eulerian counterparts.
Intimate Femicide-Suicide in Italy Between 2015 and 2019: A Comparison to Intimate Femicide Without Suicide
Authors: Solinas-Saunders Monica
Published: July 2022

The study compares incidents of intimate femicide-suicide (IFS) to incidents of intimate femicide without suicide (IFWS) that occurred in Italy between 2015 and 2019 and examines the influence of situational, sociocultural, and individual characteristics. Findings from the multivariate analysis show that incidents of IFS are more likely than incidents of IFWS to involve the use of firearms and the death of multiple victims. Furthermore, incidents of IFS are less likely than incidents of IFWS to involve previous instances of domestic violence and less likely to involve a perpetrator who was unemployed at the time of the incident.
Female Homicide and the COVID-19 Pandemic in a State of the Northeast Region of Brazil
Authors: dos Santos Emylle T. M. , de Oliveira Conceição M. , Furtado Betise M. A. S. M. , da Costa Heitor V. V. , do Bonfim Cristine V.
Published: July 2022

This paper investigates the impact of the COVID-19 pandemic in the time series of female homicides in the state of Pernambuco, Northeast of Brazil. Microdata on lethal violent crimes from the Department of Social Defense from 2015 to 2020 was used. The homicide rates were analyzed using joinpoint regression models. The results showed an upward trend in homicide rates in the Sertão mesoregion and within the 20 to 39 age group in 2020. It is concluded that confinement and social distancing aggravated the violence against women, showing the need for intersectoral planning and measures to prevent and reduce female homicides.
Service Provider to the Rescue: How Firm Recovery of Do-It-Yourself Service Failure Turns Consumers from Competitors to Satisfied Customers
Authors: Hall Matthew J. , Hyodo Jamie D.
Published: July 2022

While consumers frequently attempt to resolve their own consumption problems (i.e., do-it-yourself (DIY)), they are often unsuccessful and subsequently turn to a professional. In the present research, we consider DIY failure as a form of service failure (SF) and demonstrate that experiencing DIY service failure (DIY SF) influences consumer evaluations of subsequent firm recovery. This occurs because consumers who experience DIY SF gain greater understanding of the task (i.e., learning) through their failed attempt. This learning promotes increased appreciation of the recovering service provider’s ability, ultimately resulting in greater satisfaction with the recovery offering. We further identify mindset as a moderator of this effect, wherein those with a growth mindset are more likely to learn from failure and appreciate the abilities of the recovering service provider. By highlighting DIY SF as a novel form of SF, we demonstrate the importance of understanding customers’ prior experiences with the focal consumption problem and its solution, and of training front-line employees to better manage these customers. We test our theory across four studies using lab and field data, and close by discussing theoretical and managerial implications.
Engagement of patient and family advisors in health system redesign in Canada
Authors: Sibbald Shannon L , Kokorelias Kristina M , Embuldeniya Gayathri , Wodchis Walter P
Published: July 2022

Objectives

Globally, there has been a shift towards integrated care delivery and patient-centredness in the design of health services. Such a transformation is underway in Ontario, which is progressively using an interprofessional team-based approach known as Ontario Health Teams (OHTs) to deliver care. During their initial development, OHTs were required to integrate patient and families’ preferences, experiences and opinions in the form of consultation and partnership with patient and family advisors (PFAs). This study aimed to understand how PFAs were involved in the early stages of planning for health system change and the perceived benefits of including PFAs in system reform.

Methods

This study used a qualitative descriptive design. Semi-structured interviews were conducted with 126 participants at 12 OHTs, including PFA ( n = 16) and non-PFA ( n = 110) members (e.g. clinicians). Data were analysed thematically.

Results

We identified four themes; mechanisms of engagement, motivations to engage, challenges to PFA engagement and PFAs’ impact and added value. Overall, participants viewed PFA engagement positively and PFAs felt valued and empowered. There remain logistical challenges around PFA compensation, and the amount of time and training expected of PFAs. However, all participants believed that developing an understanding of the patient, caregiver and family experience will strengthen the engagement of PFAs in OHT planning, decisions and policies.

Conclusions

Diverse approaches to and stages of PFA engagement fostered meaningful and highly valued contributions to OHT development. These were considered critical to successfully achieving the mandate of patient-centred care reform.
Long-term impacts of L1 language skills on L2 anxiety: The mediating role of language aptitude and L2 achievement
Authors: Sparks Richard L. , Alamer Abdullah
Published: July 2022

Although researchers have found strong relationships between first language (L1) skills and second language (L2) anxiety, less is known about how L1 skills in primary school impact L2 anxiety years after L1 has been acquired. Previous research lacked evidence for the mediating role of L2 aptitude and L2 achievement in the relationship. This study applies structural equation modelling to examine pathways by which L1 skills are associated with L2 anxiety via the mediators. Sixty-five students were administered L1 skill measures from 1st–5th grades, then followed over 10 years when completing L2 courses in high school. We examined the model across six different ages and found the effect of L1 skills on L2 anxiety was indirect through L2 aptitude and L2 achievement, indicating the impact is better understood through the mediators. The effect of L2 achievement on L2 anxiety is direct, and large in magnitude. Results remained stable across different ages and invariant across gender.
Clinician factors related to the delivery of psychotherapy for autistic youth and youth with attention-deficit hyperactivity disorder
Authors: Roudbarani Flora , Tablon Modica Paula , Maddox Brenna B , Bohr Yvonne , Weiss Jonathan A
Published: July 2022

Autistic children and adolescents are more likely than non-autistic youth to experience mental health problems, such as anxiety or depression, but less likely to receive psychotherapy to address these concerns. Recent research indicates that clinician factors, such as knowledge, attitudes, confidence and beliefs, can impact their decisions to provide care, though this work has primarily focused on adults or within the context of one kind of treatment (cognitive behaviour therapy). The current study examined psychological predictors (e.g. attitudes and confidence) of clinicians’ intention to deliver psychotherapy to autistic youth and those with attention-deficit hyperactivity disorder. Participants included 611 clinicians across publicly funded agencies in Ontario, Canada. Multiple mediation analyses revealed that clinician knowledge on mental health-related topics (e.g. core symptoms, developing treatment plans and identifying progress towards treatment goals) was associated with intention to treat autistic clients or clients with attention-deficit hyperactivity disorder, and normative pressures and attitudes partially mediated this association. Clinicians felt less likely to treat autistic clients than clients with attention-deficit hyperactivity disorder, partly because of differences in attitudes, normative pressures and knowledge. This research suggests that targeted training around autism and mental health care may be a useful initiative for agency staff.

Lay abstract

Autistic children and youth often experience mental health problems, such as anxiety, depression and behavioural challenges. Although there are therapy programmes that have been found helpful in reducing these issues, such as cognitive behaviour therapy, autistic children often struggle to receive adequate mental health care. Clinicians’ knowledge, attitudes, confidence and beliefs about treating mental health problems in autistic people may be related to their choices in providing psychotherapy. Across Ontario, Canada, 611 mental health clinicians, working in publicly funded agencies, completed an online survey about their experiences and opinions on delivering therapy for autistic clients compared to those with attention-deficit hyperactivity disorder. Clinician knowledge was associated with their intention to treat autistic clients or clients with attention-deficit hyperactivity disorder, partly because of their attitudes and the social pressures or values they felt. Clinicians reported feeling less intent on providing therapy to autistic youth compared to youth with attention-deficit hyperactivity disorder because of differences in their attitudes, social pressures and knowledge. This research can inform the training and educational initiatives for mental health practitioners.
Hardware-in-the-loop exploration of energy versus emissions trade-off in eco-following scenarios for connected automated vehicles
Authors: Huang Chunan , Salehi Rasoul , Stefanopoulou Anna G , Ersal Tulga
Published: July 2022

Studies on eco-driving have mostly taken an energy-centric view and considered driving performance, while less attention has been paid on emissions behavior. This work extends in an experimentally verified way our understanding of the trade-offs among fuel economy, driving aggressiveness, and, especially, emissions in connected automated diesel-powered vehicles. Experiments are performed with a 6.7-L Ford Powerstroke diesel engine, a urea-SCR based NOx aftertreatment system, and a full model for a Ford F250 medium-duty truck in the loop to provide realistic assessment of fuel consumption, tailpipe emissions, and driving style performances. An energy and emissions conscious speed planner is leveraged to follow the traffic. This planner offers flexibility in prioritizing energy or emissions while satisfying user-defined headway constraints, and thus allows exploration of different calibrations in a unified way. Results show how various calibrations of the flexible leader following policy yield 8%–14% decrease in total fuel consumption and 64%–70% decrease in tailpipe emissions compared with a strictly constrained following policy.
An approach to select an appropriate turbocharger for matching with an internal combustion engine
Authors: El Hameur Mohamed Amine , Sehili Youcef , Cerdoun Mahfoudh , Tarabet Lyes , Ferrara Giovanni
Published: July 2022

The present paper proposes a novel methodology of turbocharging automotive engines to reach targeted performance. The actual method is tested and validated against simulation test results of two turbocharged diesel engines; engine I, three cylinders, 1.5 L, and engine II, six cylinders, 5.9 L. The present procedure is subdivided into four key parts; namely, database construction, selection procedure, turbocharger preliminary design, and engine modeling. Based on geometric dimensions and aerodynamic parameters provided by the preliminary design procedure, 3D geometries of the turbine and compressor are generated for each studied engine. After integrating previous data into a constructed turbocharger database, two turbochargers are selected for the engine I, while only one turbocharger for the engine II. The findings show that, at the engine speed of 4000 rpm, engine I matched with the adequate turbocharger reached a target power about 2.7%, compared to the original turbocharger equipping engine I. Furthermore, engine II reached a rated power of 299.3 kW at 2500 rpm which is slightly under the original one by 2.64 kW. The superimposition of the engine operating area on compressor and turbine maps provided satisfactory results in terms of turbocharger-engine output performance, fuel consumption, secure functioning and engine thermal strength. Finally, the main advantage of the developed methodology consists of its ability to be applied at both earlier and last stages of the engine turbocharging process or to find new adequate turbochargers to replace the original one for economic, mechanical or for safety reasons.
Understanding the role of exhaust gas recirculation in gasoline/diesel dual-fuel combustion soot features
Authors: Wang Xiaochen , Wang Ying , Duan Qimeng , Bai Yuanqi
Published: July 2022

Exhaust gas recirculation (EGR) can not only mitigate the pressure rise rate but also reduce the NO x emissions in dual-fuel combustion, especially at high loads. With the introduction of EGR, the thermal, chemical, and dilution effects may alter the soot oxidation reactivity and related features. However, little research has been conducted on the effect of EGR on dual-fuel combustion soot features. The paper targets this gap by assessing the oxidation reactivity, morphology and nanostructure, and oxygenated surface functional groups of particulates from dual-fuel combustion with various EGR ratios. The results from thermogravimetric analysis showed that increasing EGR ratios decreased the mass distribution of volatile organic fraction and soot oxidation reactivity under the operating point. This indicated that introducing EGR in dual-fuel combustion would increase the regeneration temperature of diesel particulate filters. Owing to the dilution and thermal effects, mean primary particle diameter gradually increased with the increasing EGR ratio. Soot particulates produced by higher EGR ratios tended to a more graphitic structure, characterized by longer fringe length but smaller tortuosity from high resolution transmission electron micrograph (HRTEM) images. The Raman results also verified the observations from HRTEM. In addition, the concentration of C-OH slightly reduced with increasing EGR ratio, while that of C=O showed no clear trend.
Deterring Children From Crime Through Sentencing: Can It Be Justified?
Authors: Crofts Thomas , Delmage Enys , Janes Laura
Published: July 2022

Children receive sentences underpinned by deterrence theory in many jurisdictions, as demonstrated by recent cases in Australia and England and Wales. This article explores whether deterrent sentencing is justified from a legal, criminological and neuroscientific perspective. Analysis of international instruments suggests that deterrent sentencing conflicts with children’s rights, particularly the obligation to factor in the child’s age and best interests. There is scant criminological evidence that deterrent sentencing works for children. The principles that underpin deterrent sentencing are at odds with the way children make decisions according to recent neuroscientific evidence. Principles of deterrence should not apply when sentencing children.
Enhanced body-force propeller model for non-uniform inflow flow and application to turning circle test of KCS in calm water
Authors: Wang Shuguang , Kim Byungsoo , Zhu Zhang , Kim Yonghwan
Published: July 2022

An enhanced body-force propeller model is developed to consider propulsion effects without solving the actual propeller geometry in ship maneuvering problems. Application to the KCS turning circle test in calm water (starting at the self-propulsion point) is conducted using the computational fluid dynamics solver, snuMHLFoam, which was developed on OpenFOAM-plus. Based on the original Hough and Ordway model, the non-uniform advance velocity of the propeller is considered using the local velocity on the inflow plane, to compute the local advance coefficient for different parts of the propeller disk when the propeller works behind a hull. The original overset algorithm is revised by introducing more flexible hole-patch definitions for the hole-cutting procedure and an iterative procedure for the donor-searching procedure to remove invalid donors. The motion decomposition of ship and rudder motions with the revised overset is implemented in order to handle body motions effectively. Self-propulsion and turning circle tests for KCS ships are successfully conducted in calm water. The predicted results, including the PI control results, turning trajectory and parameters, ship motions and velocities, forces and moments, and flow and vortical structures are illustrated and compared with the benchmark experimental data, as well as the numerical results obtained using the Maneuvering Modeling Group (MMG) model. The results indicate that the developed body-force propeller model can provide more reasonable predictions of the propulsive performance when the propeller works behind a hull. The snuMHLFoam solver, which is coupled with motion decomposition using the revised overset grid methodology, is validated to be effective and reliable.
Electromagnetic field effects of marine radar systems on the ship crew
Authors: Özdemir Ünal
Published: July 2022

Marine radars become the sources of electromagnetic pollution during navigation and anchor watchkeeping. In several scientific studies, it was reported that electromagnetic fields could lead to several serious diseases, especially in the nervous system. In the current study, electromagnetic pollution is measured at different points on ships of various tonnage and types to identify electromagnetic pollution induced by marine radars. During these measurements, SRM 3006 compact spectrum analyzer (Narda Safety Test Solutions GmbH, Germany) that was operated within the 400 MHz–6 GHz frequency range was employed with a triaxial antenna. Then, the measurement results were compared with the benchmark published by ICNIRP (International Committee on Non-Ionizing Radiation Protection), and electromagnetic pollution levels induced by marine radar antennas and possible negative consequences for the crew were analyzed.
Equitable Policies Need Equitable Practices: Alcohol- and Substance-Exposed Pregnancy as a Case Study
Authors: Deutsch Arielle R. , Jalali Mohammad S. , Stout Sarah , Frerichs Leah
Published: July 2022

There is clear need for more effective public health policies. Coupled with calls for more effective policies, increasing demand to address public health disparities experienced by systemically marginalized and historically oppressed groups emphasizes the long-standing need for policies that improve public health equity. Such need is highlighted when examining public health issues such as alcohol- and substance-exposed pregnancy (ASEP): Current policies are ineffective at reducing ASEP, and marginalized groups experience disproportionately lower benefits and higher negative consequences as a result of such policies. Powerful strategies to develop more effective policies that can account for the complexity of such issues, such as systems science methods (SSMs), are becoming popular. However, current best practices for such methods often do not emphasize the additional efforts that will be required to develop equitable, not just effective policies. Using ASEP as an example of a crucial complex issue requiring new policy, we suggest additional steps to include in SSM projects for developing more effective policies that will also help stakeholders determine high-equity policies to reduce health disparities. These steps include modeling structural differences experienced by marginalized groups via systemic racism and oppression, incorporating existing cultural and community sources of strength and resilience as key areas for policy development, and evaluating the sustainability of policies as a dimension of efficacy. We also discuss using community-based participatory approaches as a framework for all SSM processes to ensure that policy development itself is grounded in equitable shared decision-making for marginalized individuals.
Clinical Implications of Diabetic Peripheral Neuropathy in Primary Infrapopliteal Angioplasty Approach for Neuro-Ischemic Foot Wounds
Authors: Alexandrescu Vlad Adrian , Van Overmeire Lionel , Makrygiannis Georgios , Azdad Khalid , Popitiu Mircea , Paquet Séverine , Poppe Laura , Nodit Mihaela
Published: July 2022

Background:

To assess the clinical effects of diabetic peripheral neuropathy (DPN) in patients with chronic limb-threatening ischemia (CLTI) treated by primary infrapopliteal angioplasty for neuro-ischemic Rutherford 5, foot wounds.

Materials and methods:

Over a 10-year period (2009–2019), a series of 304 diabetic ischemic limbs adding or not evincible neuropathic affectation were treated by primary infrapopliteal angioplasty and their files were retrospectively reviewed. Mean length of treated arterial lesions was 6.1 cm (range 1–22 cm). Inferior limb vibration perception threshold diagnostic was performed for comparing and scoring detectable DPN in all studied diabetic patients (classed from 0 to 10 points). There were 19% limbs with normal (0–1 points) perception (group 1), 55% others with “mild” and “moderate” (2–6 points) neuropathic impairment (group 2), and 26% limbs showing “severe” (7–10 points) DPN (group 3).

Results:

Primary infrapopliteal angioplasty succeeded in 89% cases in group 1, in 82% in group 2, and in 68% of limbs in group 3. This latest group assembled the heaviest neuropathic affectation and arterial calcifications and proved the lowest clinical benefit at 36 months: 35% (95% confidence interval [CI]=22% to 48%) of primary patency, 36% (95% CI=22% to 50%) wound healing, and 54% (95% CI=39% to 69%) limb preservation rates. A comparison between groups 1 vs 3 and 2 vs 3 of primary patency (p=0.014 and p=0.043), tissue healing (p=0.049 and p=0.01), and limb salvage (p=0.006 and p=0.023) proved significant, yet without statistical weight for group 1 vs 2 (p>0.05). Overall survival was not significantly affected between groups (p=0.34).

Conclusion:

The presence of severe DPN may jeopardize the results of infrapopliteal angioplasty in terms of patency, tissue cicatrization, and limb preservation, yet without significance on survival of these patients. When present, DPN requires appropriate stratification as specific indicator in CLTI treatment.
Suprarenal Aortic Occlusion Due to Coral Reef Calcification: Successful Endovascular Management Assisted by Intravascular Lithotripsy and Visceral Protection
Authors: Sekar Natarajan , Manoj Sivaramakrishnan , Jagan Jithin
Published: July 2022

Purpose:

Suprarenal aortic occlusion due to coral reef calcification has been considered not suitable for endovascular therapy because of visceral artery involvement. Unfortunately, open surgical treatment also carries high morbidity and mortality. We describe here successful endovascular management of a case of suprarenal aortic occlusion due to coral reef calcification with the use of intravascular lithotripsy (IVL) and visceral protection.

Case Report:

A 72-year-old women presented with uncontrolled hypertension, heart failure, and intermittent claudication. She was found to have occlusion of suprarenal aorta due to coral reef calcification at the level of the celiac artery. Celiac, superior mesenteric, and left renal arteries had stenosis. Right renal artery was normal. Intravascular lithotripsy–assisted balloon angioplasty and stenting of the aorta was done. Distal embolic protection of right renal artery and superior mesenteric artery was done during this procedure. Post procedure, there was no pressure gradient across the aortic stenosis, and all visceral arterial flow was maintained. Her cardiac function improved and hypertension could be managed with a single drug. Her pedal pulses became palpable

Conclusion:

Coral reef calcification of suprarenal aorta can be safely managed by endovascular therapy using IVL and distal embolic protection of the visceral arteries.
Who Feels the Bern? An Analysis of Support for Bernie Sanders in the 2020 Democratic Primary
Authors: Altamura Christopher , Oliver Brenden
Published: July 2022

Researchers remain divided over the cause of Bernie Sanders’ strong appeal in recent Democratic primaries, alternately positing identity or ideology as decisive drivers of Sanders support. Using data from 2020 Nationscape, we conduct linear probability models that show how identity, ideology, and their interaction all explain Sanders support. Demographically, we find that Sanders voters are disproportionately young, Hispanic, and Independent. Sanders voters also differ significantly from other Democratic primary voters across several ideology variables, and are especially supportive of policies that were central to Sanders’ campaign, such as providing government-run health insurance to all Americans. Finally, we demonstrate that age cohort, the most important predictor of Sanders support, has an effect that is highly dependent upon key ideology variables. Overall, those who did not vote for Sanders in the 2020 Democratic primary are quite demographically and ideologically distinct from those voters that “felt the Bern.”
On the (Often Western, White, Male) Privilege of Self-Defense
Authors: Borchard Kurt
Published: July 2022

Here, the author presents a critical, rhyzomatic collage of previously published writing. Foucault argues dominant discourses have specific bodily effects, that such discourses shape-shift in reaffirming the status quo, and that resistance requires continual critical engagement. This textual assemblage suggests affinities with and comparisons between: conservative political discourses; legal frameworks for claiming self-defense; justifications for war; replacement theory; the re-framing of Critical Race Theory as itself racist; and variations of social support for racism and White supremacy in the United States. The text becomes a performance designed to meet the moment.
Acceptability and Use of Mind-Body Interventions Among African American Cancer Survivors: An Integrative Review
Authors: Shani Pinky , Walter Eli
Published: July 2022

Mind-body interventions have been shown to improve physical and mental health outcomes among cancer survivors, and African Americans have one of the highest cancer mortality rates of all racial/ethnic groups, while often facing considerable barriers to quality healthcare. African American cancer survivors report difficulty accessing mind-body practices, and few studies have focused exclusively on African American populations. This integrative review aims to explore the acceptability and use of mind-body interventions among African American cancer survivors. This review seeks to determine if current research indicates that mind-body interventions may be helpful in improving outcomes for African American cancer survivors. The literature search resulted in 284 studies, of which 14 met the inclusion criteria. Inclusion criteria were articles published in or after 2016, written in the English language, addressing mind-body modalities, and including a study population of ≥50% African American cancer survivors. Other reviews, meta-analyses, or studies without results were excluded. Results indicate that African American cancer survivors have expressed receptiveness to interventions incorporating mindfulness, meditation, yoga, Tai Chi, and other mind-body or complimentary/alternative medicine interventions. Still, few studies have offered such interventions exclusively to African American cancer survivors. This review indicated that African American cancer survivors across demographic backgrounds are interested in and view mind-body practices as an acceptable way to improve quality of life, pain interference, fatigue, anxiety, depression, and physical health; however, the interventions should be culturally appropriate and accessible. In conclusion, despite a growing interest in mind-body interventions, African American communities are often unaware of opportunities to engage in these practices in their communities, and mind-body practices are inaccessible due to cost or geographical location. Additional research that offers such interventions specific to African American cancer survivors is warranted.
Variability in Patient-Incurred Costs and Protocols of Regenerative Medicine Procedures for Musculoskeletal Conditions in the United States
Authors: Charnoff Jesse , Rothman Rachel , Andres Bergos Jessica , Rodeo Scott , Casey Ellen , Cheng Jennifer
Published: July 2022

Background: The use of regenerative medicine as an “off label” treatment for musculoskeletal conditions has increased in recent years. However, the literature is sparse regarding the costs of these treatments to patients. Purposes: We sought to determine the patient-incurred costs for regenerative medicine treatments performed by physicians for musculoskeletal conditions in the United States, according to primary specialty, geographic region, practice setting, and years in practice. We also sought to characterize pre- and posttreatment protocols and image guidance use. Methods: We performed a cross-sectional study with data collection occurring between April 2020 and April 2021. It began with the distribution of an online survey through an email campaign by the American College of Sports Medicine to its members. Approximately 90 emails were sent by our research team as well. Throughout the year, various participant recruitment methods were used (through Twitter, for example). Survey data included physician demographics, practice/training information, types/costs of regenerative medicine treatments performed, and pre-/postprocedure protocols. Results: One hundred physicians who self-reported performing standalone regenerative medicine procedures participated in this online survey. According to the responses, the most common treatments performed were platelet-rich plasma (PRP; 100%), bone marrow concentrate (BMC; 41%), microfragmented adipose grafting (36%), prolotherapy (33%), and bone marrow aspirate (BMA; 21%) administered to the peripheral joints, tendons/muscles, ligaments, and/or spine. Overall, the respondents reported large variations in treatment costs to patients; BMA and BMC were the most expensive and had the largest ranges in costs for all anatomical locations. Costs for PRP were lower than those for BMA and BMC, with less variation. Physicians in private practice reported higher PRP, BMC, and BMA costs in the peripheral joints than those in academic settings. Most physicians recommended avoiding non-steroidal anti-inflammatory drugs pre- and postprocedure, and 74% recommended physical therapy postprocedure. Conclusions: Findings from a survey of physicians who provide regenerative medicine procedures as off-label treatment for musculoskeletal conditions suggest that there is variation in related patient-incurred costs. Future studies should explore associations between treatment costs and outcomes.
“Terrifying and Exhausting”: Secondary Victimization in Title IX Proceedings at U.S. Higher Education Institutions
Authors: Roskin-Frazee Amelia
Published: July 2022

Students at United States colleges and universities increasingly turn to campus Title IX processes to address sexual violence, but little research exists on the emotional fallout of Title IX processes and student perceptions of process bias. This paper presents an analysis of 72 responses to a 2021 survey of Title IX process complainants and respondents at higher education institutions. While students on both sides of Title IX processes experienced negative emotions, complainants often minimized these experiences while respondents emphasized them. This form of comparative secondary victimization risks further marginalizing complainant voices at higher education institutions.
Landscape of coronavirus disease 2019 clinical trials: New frontiers and challenges
Authors: Halabi Susan , Zhou Jinyi , He Yijie , Bressler Linda R , Hernandez Adrian F , Turner Nicholas A , Hong Hwanhee
Published: July 2022

Background/Aim

The number of coronavirus disease 2019 deaths and cases continues to increase globally. Novel therapies are urgently needed to treat patients with coronavirus disease 2019. We sought to provide a critical review of trials designed during the coronavirus disease 2019 pandemic. Our primary goal was to provide a critical review of the landscape of clinical trials designed to address the coronavirus disease 2019 pandemic. Specifically, we were interested in assessing the design of phase II/III and phase III interventional trials.

Methods

We utilized the ClinicalTrials.gov database to include trials registered between 1 December 2019 and 11 April 2021 to survey the current landscape of clinical trials for coronavirus disease 2019. Variables extracted included: National Clinical Trial number, title, location, sponsor, study type, start date, completion date, gender group, age group, primary outcome, secondary outcome, overall status, and associated references.

Results

About 57% of studies were interventional, 14.5% were phase III trials, and the majority of the therapeutic trials included hospitalized patients. There were 52 primary composite outcomes and 285 unique interventions spanning 10 drug classes. The outcomes, disease severity, and comparators varied substantially across trials, and the trials were often too small to be definitive.

Conclusion

These findings are relevant as we strongly advocate for global coordination of efforts through the use of common platforms that enable harmonizing of endpoints, collection of common key variables and clear definition of disease severity to have clinically meaningful results from clinical trials.
An adaptive clinical trial design to identify the target dose of tenecteplase for treatment of acute pulmonary embolism
Authors: Yeatts Sharon D , Foster Lydia D , Barsan William G , Berry Nicholas S , Callaway Clifton W , Lewis Roger J , Saville Benjamin R , Silbergleit Robert , Kline Jeffrey A
Published: July 2022

Background/Aims

Fibrinolytic therapy with tenecteplase has been proposed for patients with pulmonary embolism but the optimal dose is unknown. Higher-than-necessary dosing is likely to cause excess bleeding. We designed an adaptive clinical trial to identify the minimum and assumed safest dose of tenecteplase that maintains efficacy.

Methods

We propose a Bayesian adaptive, placebo-controlled, group-sequential dose-finding trial using response-adaptive randomization to preferentially allocate subjects to the most promising doses, dual analyses strategies (continuous and dichotomized) using a gatekeeping approach to maximize clinical impact, and interim stopping rules to efficiently address competing trial objectives. The operating characteristics of the proposed design were evaluated using Monte Carlo simulation across multiple hypothetical efficacy scenarios.

Results

Simulation demonstrated response-adaptive randomization can preferentially allocate subjects to doses which appear to be performing well based on interim data. Interim decision-making, including the interim evaluation of both analysis strategies with gatekeeping, allows the trial to continue enrollment when success with the dichotomized analysis strategy appears sufficiently likely and to stop enrollment and declare superiority based on the continuous analysis strategy when there is little chance of ultimately declaring superiority with the dichotomized analysis.

Conclusion

The proposed design allows evaluation of a greater number of dose levels than would be possible with a non-adaptive design and avoids the need to choose either the continuous or the dichotomized analysis strategy for the primary endpoint.
Going beyond the spacing effect: Does it matter how time on a task is distributed?
Authors: Murphy Dillon H , Bjork Robert A , Bjork Elizabeth L
Published: July 2022

We assessed the effects of removing some constraints that characterise traditional experiments on the effects of spaced, rather than massed, study opportunities. In five experiments—using lists of to-be-remembered words—we examined the effects of how total study time was distributed across multiple repetitions of a given to-be-remembered word. Overall, within a given list, recall profited from study time being distributed (e.g., four 1-s presentations or two 2-s presentations vs one 4-s presentation). Among the implications of these findings is that if students choose to engage in massed studying (by virtue of constraints on their study time or a failure to appreciate the benefits of spaced study sessions), then studying the information twice but for half the time may produce memory benefits in a single study session.
Designing variable reflection coefficient for upstream and downstream terminations to study their effect on flame thermoacoustics
Authors: Saxena Vertika , Kornilov Viktor , Lopez Arteaga Ines , De Goey LPH
Published: July 2022

In this paper, the design, construction and results of experiments performed on a generic combustion system are presented. The setup is supplemented by various weakly frequency-dependent variable reflection coefficient (RC) devices as upstream and downstream acoustic terminations. The main objective of building such terminations is to provide a method to study burner/flame stability when it is placed between various acoustic configurations (RC: 0.1-0.9) and to determine the figure of merit of a burner based on the evaluation of its map of (in-)stability. Furthermore, burner design parameters such as the burner perforation pattern (holes diameter, pitch, perforation area, etc.) which will provide combustion stability for the widest range of burner's acoustic embedding conditions are identified. The experimental setup comprises of an upstream acoustic termination, a telescopic tube with adjustable length is placed after the upstream termination followed by the burner and the quartz tube. On the top of the quartz tube, the replaceable downstream terminations are installed. Nine downstream terminations are constructed by stacking plates of 0.25 mm thickness separated by spacers ranging from 0.1 to 1 mm thickness. Particularly, for the burners tested in this setup, the smallest hole diameter burner (with the largest perforation area) results in the largest stable region on the stability map in the parameter space. An increase in the flow velocity leads to an increase in the frequency of instability and makes a stable system tend to become unstable, while an increase in the equivalence ratio contributes to stabilizing system instability
Persistent Performance Differences in Lodging Properties
Authors: Canina Linda , Potter Gordon
Published: July 2022

Studies have documented the existence of persistent performance differences across business units and firms in many industries and countries. Unfortunately, little is known about the causes of these performance differentials. Using property-level data from the lodging industry, this study documents the existence of large and persistent performance differentials across lodging units. These differences exist after controlling for the resources utilized for the production of the service as well as market conditions and hotel property characteristics and are most persistent for the highest and the lowest performers. Similar to studies that analyzed performance differences in other industries, our analysis leaves a large portion of the variation in performance differences unexplained. However, we do find that a small portion of these performance differences is positively related to the hotel property’s choice regarding chain size and hotel portfolio company scope, suggesting the possibility of benefits from scale economies and/or scope. Understanding how performance differences arise and persist requires a close look into less deterministic, quantifiable, and tangible factors such as managerial practices, decision-making processes, innovation, knowledge creation, the transfer of knowledge, the flow of information, compensation, and personnel policies, among others. In other words, there is much unexplained and yet to be discovered here, resulting in a ripe area for future research. Future research that links attributes of the industry’s demand, management controls, or technology to factors driving productivity may help explain, and perhaps enhance, the industry’s productivity growth.
Anthroposophical Climate Science Denial
Authors: Hansson Sven Ove
Published: July 2022

Climate science denial has a perhaps surprisingly strong standing in anthroposophy. Anthroposophical deniers of climate science usually do not contest the existence of global warming, but they ascribe it to “cosmic” processes that are largely described in astrological terms. Thoroughly refuted claims that ongoing global warming depends on variations in solar activity have been adopted by anthroposophists. This article proposes three major explanations for the persistence of climate science denial in the anthroposophical movement: Anthroposophists constantly look for guidance on scientific issues in the writings of their founder Rudolf Steiner (1861–1925), who made claims far off from the mainstream science of his time. They consider the material world to be constantly influenced by “spiritual” factors, including astrological constellations and a host of supernatural beings. Finally, they cherish ideas on a predetermined, largely cyclic, cosmic plan, of which humanity is a part.
Association between Social Activity and Development of Dementia in Hearing Impairment: A Cohort Study in Japan from Japan Gerontological Evaluation Study
Authors: Kojima Kaori , Okada Eisaku , Ojima Toshiyuki , Aida Jun , Hiratsuka Yoshimune , Kondo Katsunori
Published: July 2022

We aimed to clarify the association between social activity and the development of dementia in older adults by hearing-impaired (HI) status. We applied a community-based prospective cohort study over 6 years as part of the Japan Gerontological Evaluation Study. The study included 53,549 participants aged 65 years and older who did not require long-term care. A baseline questionnaire survey was conducted; explanatory variables included physical and social activities, and the objective variable was dementia onset assessed by standardized protocol. Cox regression models were used to calculate hazard ratios (HRs) for dementia stratified by HI status. During the follow-up period, 6013 (11.2%) participants developed dementia. Analyses revealed increased dementia risk for participants with HI who participated in the following activities less than once a month: sport groups (HR 2.17, 95% CI 1.53-3.08), hobby groups (HR 1.70, 95% CI 1.34-2.17), going out (HR 2.19, 95% CI 1.51-3.17), and meeting with friends (HR 1.27, 95% CI 1.06-1.53). HI and lack of social activity increase the risk of dementia. The study results indicate that there is an association between low social activity and the development of dementia in people with HI; the strongest associations were found for low participation in sports and hobby groups.
Social Functions of Students’ Translingual Composing in an English-Medium, Second-Grade Classroom
Authors: Rowe Lindsey W.
Published: July 2022

While translingual and translanguaging orientations have been posited as supportive for emergent bilingual children in schools, limited research explores how children in English-medium spaces enact translingual composing practices. Drawing on theorizations of translingual composing as an interactional process, this paper analyzes data from a year-long, qualitative study. It explores how children in a second-grade classroom in an English-medium school composed when invited to use multiple language resources during Writing Workshop. Specially, it examines two questions: (1) What translingual composing practices did children employ? and (2) How did children's use of translingual composing function socially? Descriptive analyses of students’ writing show that, across the year, children created increasingly sophisticated translingual texts. Inductive analyses of events involving these texts identified six social functions that children interactionally constructed for their translingual writing: (1) responding to the teacher, (2) addressing bilingual audiences, (3) gaining peers’ attention, (4) teaching others a language beyond English, (5) positioning oneself as a language learner, and (6) positioning oneself as bilingual. These patterns illustrate the composing-oriented, peer-oriented, and identity-oriented work children enacted, in-the-moment, through their talk about translingual texts. Translingual texts became the occasion for new sorts of interactions that opened space for students to negotiate ideologies and positionings that valued the use of multiple named languages in the classroom writing space.
Future land use conflicts: Comparing spatial scenarios for urban-regional planning
Authors: Henríquez Cristian , Morales Mauricio , Qüense Jorge , Hidalgo Rodrigo
Published: July 2022

Latin America’s intensive urbanization processes are triggering rapid peri-urban transformations and the expansion of cities. These include accelerated metropolization processes, urban sprawl, and the emergence of new conurbations. These changes parallel the expansion of highly profitable agricultural activities and plantations linked to international markets. This paper aims to analyze land use/cover changes between 1990 and 2050 in the Quillota Province, Valparaíso Region, Chile. Specific objectives considered (1) analyzing changes in land use/cover trajectories between 1990 and 2017, (2) simulating changes in land use/cover based on three scenarios of territorial planning to 2050 (trending, ecological planning, and spatial planning), and (3), identifying the areas most likely to be modified by urbanization and agricultural activity as a result of biodiversity loss in the study area. The Dyna-CLUE model implemented was complemented with GIS techniques for the analysis of land use/cover trajectories that allowed classifying and characterizing the most dynamic land uses/cover within the Quillota Province, such as urban land uses. The results of simulations to 2050 show a probable conurbation of medium-sized cities of Quillota-La Cruz-Calera, and future land use conflicts between peri urban-agricultural land use and plantation-natural conservation land use. The results suggest that it is essential to choose scenarios to ensure sustainable land use planning to control urban and peri-urban sprawl and protect areas of high natural value.
It Takes a Team: Working Together to Meet the Needs of Young Children With Autism Spectrum Disorder in an Inclusive Setting
Authors: Bateman Katherine J. , Schwartz Ilene S. , Gauvreau Ariane N.
Published: July 2022

Collaboration is a key component of high-quality programs for all young children, especially those with autism spectrum disorder (ASD). Yet, this practice is often one of the most challenging aspects of early childhood special education. Effective collaboration practices among multiple stakeholders are needed to ensure positive outcomes. Processes of teaming and collaboration in Project DATA, an early intervention program designed to support preschoolers with ASD within school-based settings, are examined and discussed. The importance of collaboration is demonstrated through stories, lessons, and experiences of working with children and families affected by ASD. Guidelines for effective teaming and collaboration are provided.