bluuebunny/crossref_metadata_2025 huggingface dataset:
An Evaluation of Skin and Immunological Responses after Using a Novel Cross-Linked Porcine-Based Dermal Injectable Collagen with Lidocaine for Nasolabial Fold Correction
Authors: Tai Hao-Chih , Liao Yi-Hua , Chang Ya-Ching , Yang Chin-Yi , Horng Shyue-Yih , Kuo Yuan-Sung , Sheen Yi-Shuan , Huang Yu-Huei , Hui Rosaline Chung-Yee , Chen Tim-Mo , Tzeng Yuan-Sheng , Wang Chih-Hsin , Teng Shou-Cheng , Chang Chun-Kai Oscar , Chou Chang-Yi
Published: September 2024

Background: Hypersensitivity to the new dermal injectable porcine-based collagen with lidocaine featuring a novel cross-linking technology (test filler) for nasolabial fold correction was compared to the commercially available traditional cross-linked dermal injectable porcine-based collagen with lidocaine (control filler). Methods: Recruited participants (n = 279) received a single 0.1 mL intradermal injection of either test filler or control filler in the left forearm as a screening skin allergy test. Injection sites were assessed clinically at 24 h post-implant. Treatment was given to 252 successfully screened participants, and injection sites were monitored for 21 days. Immunological examinations were performed at screening and then at 4 and 24 weeks post-treatment. Observations for adverse events continued until the 52nd week. Results: Intradermal allergy testing results were negative for all the test recipients (0/124) and positive for two control recipients (2/132, 1.5%). Most of the participants exhibited no changes in serum immunoglobulin (IgG, IgM) and complement (C3, C4) levels. No serious adverse events related to the device were recorded. Most adverse events were common complications of dermal filler treatment and were related to the injection site. Most adverse effects were resolved or under control by 52 weeks. Conclusions: Hypersensitivity reactions with the test filler were lower than those with the control filler, validating the safe use of test filler for nasolabial fold correction without the need for pretreatment skin testing.
Bisphenol F and Bisphenol S in a Complex Biomembrane: Comparison with Bisphenol A
Authors: Villalaín José
Published: September 2024

Bisphenols are a group of endocrine-disrupting chemicals used worldwide for the production of plastics and resins. Bisphenol A (BPA), the main bisphenol, exhibits many unwanted effects. BPA has, currently, been replaced with bisphenol F (BPF) and bisphenol S (BPS) in many applications in the hope that these molecules have a lesser effect on metabolism than BPA. Since bisphenols tend to partition into the lipid phase, their place of choice would be the cellular membrane. In this paper, I carried out molecular dynamics simulations to compare the localization and interactions of BPA, BPF, and BPS in a complex membrane. This study suggests that bisphenols tend to be placed at the membrane interface, they have no preferred orientation inside the membrane, they can be in the monomer or aggregated state, and they affect the biophysical properties of the membrane lipids. The properties of bisphenols can be attributed, at least in part, to their membranotropic effects and to the modulation of the biophysical membrane properties. The data support that both BPF and BPS, behaving in the same way in the membrane as BPA and with the same capacity to accumulate in the biological membrane, are not safe alternatives to BPA.
Prediction Modeling and Driving Factor Analysis of Spatial Distribution of CO2 Emissions from Urban Land in the Yangtze River Economic Belt, China
Authors: Wang Chao , Wang Jianing , Ma Le , Jia Mingming , Chen Jiaying , Shao Zhenfeng , Chen Nengcheng
Published: September 2024

In recent years, China’s urbanization has accelerated, significantly impacting ecosystems and the carbon balance due to changes in urban land use. The spatial patterns of CO2 emissions from urban land are essential for devising strategies to mitigate emissions, particularly in predicting future spatial distributions that guide urban development. Based on socioeconomic grid data, such as nighttime lights and the population, this study proposes a spatial prediction method for CO2 emissions from urban land using a Long Short-Term Memory (LSTM) model with added fully connected layers. Additionally, the geographical detector method was applied to identify the factors driving the increase in CO2 emissions due to urban land expansion. The results show that socioeconomic grid data can effectively predict the spatial distribution of CO2 emissions. In the Yangtze River Economic Belt (YREB), emissions from urban land are projected to rise by 116.23% from 2020 to 2030. The analysis of driving factors indicates that economic development and population density significantly influence the increase in CO2 emissions due to urban land expansion. In downstream cities, CO2 emissions are influenced by both population density and economic development, whereas in midstream and upstream city clusters, they are primarily driven by economic development. Furthermore, technology investment can mitigate CO2 emissions from upstream city clusters. In conclusion, this study provides a scientific basis for developing CO2 mitigation strategies for urban land within the YREB.
Molecular Characterization, Evolution and Expression Analysis of Ammonium Transporter from Four Closely Related Bactrocera Species (Tephritidae)
Authors: Zhang Jie , Wang Qi , Liu Chenhao , Liu Jiaying , Qian Qian , Ru Chuanjian , Liu Leyuan , Yan Shanchun , Liu Wei , Wang Guirong
Published: September 2024

Numerous insects are attracted to low levels of ammonia, utilizing it as a cue to locate food sources. The Ammonium Transporter (Amt), a highly conserved, atypical olfactory receptor, has been shown to mediate the detection of ammonia in insects. While the attraction of Tephritidae to ammonia is well established, knowledge about the Amt in this family is limited. The species Bactrocera dorsalis (Hendel 1912), Bactrocera cucurbitae (Coquillett 1899), Bactrocera correcta Bezzi 1916 and Bactrocera tau (Walker 1849), which are common agricultural pests within Tephritidae, exhibit numerous ecological similarities, offering a solid foundation for studying Amt characteristics in this family. In this study, we elucidated the sequences, evolutionary relationships, and expression patterns of Amt in these four species. The results indicated that these Amts share the same open reading frame, containing 1770 bp that encode a protein of 589 amino acid residues. These Amt proteins exhibit the typical structural characteristics of Amts, including an 11-transmembrane domain with an extracellular N-terminus and an intracellular C-terminus. They also have the ability to form trimers in the membrane. Additionally, they contain three conserved amino acid residues essential for ammonia transport: A189, H195, and H352. Phylogenetic and expression pattern analyses showed that they are highly conserved in Diptera and are significantly expressed in antennae. This study is the first report characterizing the Amt gene in four Tephritidae species. These findings provide a foundation for further exploration into the roles of these genes in their particular biological contexts.
Design and Coupled Moisture–Thermal Transfer Simulation of Opposite Cross-Section Polyethylene Terephthalate Knitted Fabric with Hygroscopic Quick-Drying Capability
Authors: Lu Canyi , Liu Encheng , Li Yingzhan , Zhu Guocheng , Shao Yiqin
Published: September 2024

In addition to sportswear and outdoor equipment, moisture-absorbent quick-drying fabrics are also widely used in everyday clothing and home textiles. In this study, three types of weft-knitted fabrics were designed using Coolmax fiber and polypropylene fiber. The Coolmax/PP fabric exhibits good stretchability with a strain of 180.5% and achieves a high cumulative individual transfer capability of 691.6%, with a water absorption rate of 50.2%/s. The moisture conductivity gradient presented good moisture and heat conductivity in a simulated human body temperature environment using an infrared camera. Furthermore, mathematical modeling was constructed and visual simulation analysis was conducted to explore moisture–thermal transfer behavior. The simulation results closely align with experimental data, providing insights into designing flexible and wearable quick-drying fabrics for thermal management.
The Impact of Metabolic Syndrome on Heart Failure in Young Korean Population: A Nationwide Study
Authors: Kim Tae-Eun , Kim Do Young , Kim Hyeongsu , Sung Jidong , Kim Duk-Kyung , Lee Myoung-Soon , Han Seong Woo , Kim Hyun-Joong , Ki Hyun Kyun , Kim Sung Hea , Ryu Kyu-Hyung
Published: September 2024

Limited data are available regarding the effect of metabolic syndrome on heart failure (HF) development in young individuals. Utilizing data from the Korean National Health Insurance Service, we included a total of 1,958,284 subjects in their 40s who underwent health screening between January 2009 and December 2009 in Korea. Subjects were classified into three groups: normal, pre-metabolic syndrome (Pre-MetS), and metabolic syndrome (MetS). MetS was identified in 10.58% of males and 5.21% of females. The hazard ratio for HF in subjects with MetS was 1.968 (95% CI: 1.526–2.539) for males and 2.398 (95% CI: 1.466–3.923) for females. For those with Pre-MetS, the hazard ratio was 1.607 (95% CI: 1.293–1.997) in males and 1.893 (95% CI: 1.43–2.505) in females. Additionally, acute myocardial infarction and low hemoglobin levels were identified as significant risk factors for HF in both genders. MetS approximately doubled the risk of developing HF in individuals in their 40s. Pre-MetS was also a significant risk factor for HF in this population.
Exploring Radioiodinated Anastrozole and Epirubicin as AKT1-Targeted Radiopharmaceuticals in Breast Cancer: In Silico Analysis and Potential Therapeutic Effect with Functional Nuclear Imagining Implications
Authors: Binmujlli Mazen Abdulrahman
Published: September 2024

This study evaluates radio-iodinated anastrozole ([125I]anastrozole) and epirubicin ([125I]epirubicin) for AKT1-targeted breast cancer therapy, utilizing radiopharmaceutical therapy (RPT) for personalized treatment. Through molecular docking and dynamics simulations (200 ns), it investigates these compounds’ binding affinities and mechanisms to the AKT1 enzyme, compared to the co-crystallized ligand, a known AKT1 inhibitor. Molecular docking results show that [125I]epirubicin has the highest ΔGbind (−11.84 kcal/mol), indicating a superior binding affinity compared to [125I] anastrozole (−10.68 kcal/mol) and the co-crystallized ligand (−9.53 kcal/mol). Molecular dynamics (MD) simulations confirmed a stable interaction with the AKT1 enzyme, with [125I]anastrozole and [125I]epirubicin reaching stability after approximately 68 ns with an average RMSD of around 2.2 Å, while the co-crystallized ligand stabilized at approximately 2.69 Å after 87 ns. RMSF analysis showed no significant shifts in residues or segments, with consistent patterns and differences of less than 2 Å, maintaining enzyme stability. The [125I]epirubicin complex maintained an average of four H-bonds, indicating strong and stable interactions, while [125I]anastrozole consistently formed three H-bonds. The average Rg values for both complexes were ~16.8 ± 0.1 Å, indicating no significant changes in the enzyme’s compactness, thus preserving structural integrity. These analyses reveal stable binding and minimal structural perturbations, suggesting the high potential for AKT1 inhibition. MM-PBSA calculations confirm the potential of these radio-iodinated compounds as AKT1 inhibitors, with [125I]epirubicin exhibiting the most favorable binding energy (−23.57 ± 0.14 kcal/mol) compared to [125I]anastrozole (−20.03 ± 0.15 kcal/mol) and the co-crystallized ligand (−16.38 ± 0.14 kcal/mol), highlighting the significant role of electrostatic interactions in stabilizing the complex. The computational analysis shows [125I]anastrozole and [125I]epirubicin may play promising roles as AKT1 inhibitors, especially [125I]epirubicin for its high binding affinity and dynamic receptor interactions. These findings, supported by molecular docking scores and MM-PBSA binding energies, advocate for their potential superior inhibitory capability against the AKT1 enzyme. Nevertheless, it is crucial to validate these computational predictions through in vitro and in vivo studies to thoroughly evaluate the therapeutic potential and viability of these compounds for AKT1-targeted breast cancer treatment.
Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia
Authors: Ntolkeras Georgios , Touserkani Fatemeh Mohammadpour , Chiu Michelle Y. , Prabhu Sanjay P. , Stone Scellig , Rotenberg Alexander
Published: September 2024

Sensory integration is the province of the parietal lobe. The non-dominant hemisphere is responsible for both body sides, while the dominant hemisphere is responsible for the contralateral hemi-body. Furthermore, the posterior cingulate cortex (PCC) participates in a network involved in spatial orientation, attention, and spatial and episodic memory. Laser interstitial thermotherapy (LiTT) is a minimally invasive surgery for focal drug-resistant epilepsy (DRE) that can target deeper brain regions, and thus, region-specific symptoms can emerge. Here, we present an 18-year-old right-handed male with focal DRE who experienced seizures characterized by sensations of déjà vu, staring spells, and language disruption. A comprehensive evaluation localized the seizure focus and revealed a probable focal cortical dysplasia (FCD) in the left posterior cingulate gyrus. The patient underwent uneventful LiTT of the identified lesion. Post-operatively, he developed transient ipsilateral spatial neglect and contralateral sensory loss, as well as acalculia. His sensory symptoms gradually improved after the surgery, and he remained seizure-free after the intervention for at least 10 months (until the time of this writing). This rare case of ipsilateral spatial and visual hemineglect post-LiTT in epilepsy underscores the importance of recognizing atypical neurosurgical outcomes and considering individual variations in brain anatomy and function. Understanding the dynamics of cortical connectivity and handedness, particularly in pediatric epilepsy, may be crucial in anticipating and managing neurocognitive effects following epilepsy surgery.
The Effects of Rice Bran on Neuroinflammation and Gut Microbiota in Ovariectomized Mice Fed a Drink with Fructose
Authors: Chao Yu-Wen , Tung Yu-Tang , Yang Suh-Ching , Shirakawa Hitoshi , Su Li-Han , Loe Pei-Yu , Chiu Wan-Chun
Published: September 2024

Rice bran, which is abundant in dietary fiber and phytochemicals, provides multiple health benefits. Nonetheless, its effects on neuroinflammation and gut microbiota in postmenopausal conditions are still not well understood. This study investigated the effects of rice bran and/or tea seed oil supplementation in d-galactose-injected ovariectomized (OVX) old mice fed a fructose drink. The combination of d-galactose injection, ovariectomy, and fructose drink administration creates a comprehensive model that simulates aging in females under multiple metabolic stressors, including oxidative stress, estrogen deficiency, and high-sugar diets, and allows the study of their combined impact on metabolic disorders and related diseases. Eight-week-old and 6–8-month-old female C57BL/6 mice were used. The mice were divided into six groups: a sham + young mice, a sham + old mice, an OVX + soybean oil, an OVX + soybean oil with rice bran, an OVX + tea seed oil (TO), and an OVX + TO with rice bran diet group. The OVX groups were subcutaneously injected with d-galactose (100 mg/kg/day) and received a 15% (v/v) fructose drink. The rice bran and tea seed oil supplementation formed 10% of the diet (w/w). The results showed that the rice bran with TO diet increased the number of short-chain fatty acid (SCFA)-producing Clostridia and reduced the number of endotoxin-producing Tannerellaceae, which mitigated imbalances in the gut–liver–brain axis. Rice bran supplementation reduced the relative weight of the liver, levels of hepatic triglycerides and total cholesterol; aspartate transaminase and alanine aminotransferase activity; brain levels of proinflammatory cytokines, including interleukin-1β and tumor necrosis factor-α; and plasma 8-hydroxy-2-deoxyguanosine. This study concludes that rice bran inhibits hepatic fat accumulation, which mitigates peripheral metaflammation and oxidative damage and reduces neuroinflammation in the brain.
Influence of Dietary Heritage in a Restricted Geographic Area and Role of Food Additives on Risk of Recurrent Kidney Stone
Authors: Bolasco Piergiorgio , Reggiardo Giorgio
Published: September 2024

Dietary factors may be implicated in the formation of kidney stones and should be closely monitored. To achieve this aim, patients are routinely assessed by means of generic dietary recall, a tool widely used by authors in a range of extensive patient populations to record food intake; the findings obtained, however, may be skewed due to dietary variations and underestimation of the effect of food additives. Fifty Frequent Kidney Stone Formers (FKSFs, mean age: 54.3 ± 13.9 years) with normal kidney function, absence of comorbidities, and reliable compliance were selected from a total of 68 patients’ resident in Sardinia, an Italian island where genetic admixtures have been relatively rare for generations. The study, conducted from 1 January 2020 to 31 December 2023, was aimed at assessing nutritional values based on the meticulous recording of food quantities, quality, and potential modifications related to food preparation. Patients were selected during an initial clinical check-up and all efforts made to ensure they were capable of reliably recording all food and drinks consumed. A seven-day food diary was provided in which food and drink intake and their impact on 24 h urine output was recorded. The following parameters were measured in both foods and urine output: citrates, oxalates, calcium, phosphorous, uric acid, proteins and nitrogen compounds, magnesium, sulfates, potassium, carbohydrates, free fatty acids. Study outcomes established the presence of hypocitraturia, hyperoxaluria, hypercalciuria, and moderately high levels of nitrogen compounds. Univariate analysis followed by multivariate analysis for further confirmation were performed and the following observations made. Citrate intake correlated with citraturia but did not promote oxaluria; calcium intake promoted onset of sulfaturia, azoturia, and ammoniuria, whilst magnesium correlated with magnesiuria but not with oxaluria, calciuria, phosphaturia, and azoturia; sulfate intake elicited onset of azoturia but not kaliuresis; potassium intake promoted oxaluria and protein intake resulted in onset of ammoniuria and azoturia. (A) The chemical composition of urine based on dietary intake is hard to predict without taking into account the presence of dietary and urinary interferents; (B) the geographic isolation of patients studied underlines the importance of epigenetics in maintaining a traditional dietary heritage. (C) Moreover, the widespread use of food additives should consistently be taken into account to ensure a correct diagnosis of FKSF and set up a valid treatment plan.
From Waste to Health: Olive Mill Wastewater for Cardiovascular Disease Prevention
Authors: Mattioli Laura Beatrice , Corazza Ivan , Budriesi Roberta , Hrelia Silvana , Malaguti Marco , Caliceti Cristiana , Amoroso Rosa , Maccallini Cristina , Crupi Pasquale , Clodoveo Maria Lisa , Muraglia Marilena , Carocci Alessia , Tardugno Roberta , Barbarossa Alexia , Corbo Filomena
Published: September 2024

Waste from the agri-food chain represents a valuable reservoir of organic compounds with health-promoting properties. Momast Plus 30 Bio (MP30B) is a derivative obtained from olive-oil wastewater. Its enrichment in hydroxytyrosol (HT) via a patented technique has paved the way for its potential application as a dietary supplement in preventing cardiovascular diseases. MP30B demonstrates no significant alteration in cardiac and vascular parameters in “ex vivo” studies. However, it exhibits a strong ability to remove reactive oxygen species and exerts anti-inflammatory effects, notably reducing the concentration of iNOS and mitigating heart infections in “in vitro” experiments. Furthermore, MP30B slightly decreases the stiffness of the “ex vivo” thoracic aorta, potentially resulting in lowered arterial pressure and enhanced energy transfer to a normal ventricle. Based on these findings, we posit MP30B as a promising extract for cardiovascular disease prevention, and its specific antibacterial properties suggest its utility in preventing cardiac infections.
Characterization and Evaluation of the Cytotoxicity of Pregabalin Gels for Oral Application
Authors: Xavier Gabriela Monteiro Barbosa , Ferreira Lindalva Maria de Meneses Costa , Passos Marcele Fonseca , Rodrigues Ana Paula Drummond , Franco Felipe Tuji de Castro , Silva Cecy Martins , Silva Júnior José Otávio Carréra , Ribeiro-Costa Roseane Maria , Araújo Jesuína Lamartine Nogueira
Published: September 2024

The efficacy of pregabalin in pain treatment has led to the search for new formulations for its use through different routes of administration. This study aimed to prepare, characterize, and evaluate the cytotoxicity of pregabalin (PG) gels for topical application in the oral cavity. Solutions with three different concentrations of PG were prepared and added to a 1.0% carbopol gel base. Thermal analyses (TG and DSC) and FTIR were performed on the gel and pure pregabalin. Stability (preliminary and accelerated) and rheology studies were also conducted on the gels. Cytotoxicity was evaluated in human gingival fibroblasts in the following groups: WG (1.0% carbopol gel base), PG2G (2.0% pregabalin gel), PG5G (5.0% pregabalin gel), and PG10G (10% pregabalin gel). A transparent and homogeneous gel with a pH of 6 was obtained. The formulations showed stability, and the different drug concentrations did not influence the product’s characteristics. None of the tested groups showed cytotoxicity for the analyzed cells. The pregabalin gels exhibited favorable and non-toxic characteristics for human gingival fibroblasts in vitro. Therefore, this product may be a promising therapeutic alternative for topical application in the oral mucosa.
Pigment Complex, Growth and Chemical Composition Traits of Boreal Sphagnum Mosses (Mire System “Ilasskoe”, North-West of European Russia)
Authors: Shtang Anastasiya , Ponomareva Tamara , Skryabina Alexandra
Published: September 2024

Sphagnum mosses play a significant role in peat formation and carbon sequestration in mire ecosystems. It is critical to investigate the productivity and chemical composition of different Sphagnum species in order to assess their role in the global carbon cycle and potential in light of climate change. The data on productivity and growth characteristics during the growing season, group chemical composition and elemental composition at the beginning and end of the growing season, as well as aspects of the pigment complex operation, were collected for four Sphagnum species: Sphagnum lindbergii Schimp., S. fuscum (Schimp.) Klinggr., S. divinum Flatberg & K. Hassel, and S. squarrosum Crome. High cover density and productivity, low ability to decompose, and constancy of the pigment complex of S. fuscum reflect a high degree of adaptation to the specific conditions of ridges. A constant chemical composition of S. lindbergii during the growing season can be explained by stable conditions of hollows that allow it to maintain its metabolic processes, but the light conditions in hollows bring the reaction of the pigment apparatus of this species closer to shaded S. divinum and S. squarrosum. S. lindbergii and S. squarrosum contain more nitrogen than other species and have a greater ability to decompose.
Induction and Suspension Culture of Panax japonicus Callus Tissue for the Production of Secondary Metabolic Active Substances
Authors: Lv Siqin , Ding Fan , Zhang Shaopeng , Nosov Alexander M. , Kitashov Andery V. , Yang Ling
Published: September 2024

Using Panax japonicus as research material, callus induction and culture were carried out, and high-yielding cell lines were screened to establish a suspension culture system that promotes callus growth and the accumulation of the “total saponins” (total content of triterpenoid glycosides or ginsenosides). Using the root as an explant, the medium for callus induction and proliferation was optimized by adjusting culture conditions (initial inoculation amount, carbon source, shaking speed, hormone concentration, culture time) and a high-yielding cell line with efficient proliferation and high total saponins content was screened out. The conditions of suspension culture were refined to find out the most suitable conditions for the suspension culture of callus, and finally, the suspension culture system was established. We found that the lowest (5%) contamination rate was achieved by disinfecting the fresh roots with 75% alcohol for 60 s, followed by soaking in 10% NaClO for 15 min. The highest induction rate (88.17%) of callus was obtained using the medium MS + 16.11 μmol·L−1 NAA + 13.32 μmol·L−1 6-BA + 30.0 g·L−1 sucrose + 7.5 g·L−1 agar. The callus was loose when the callus subcultured on the proliferation medium (MS + 5.37 μmol·L−1 NAA + 13.32 μmol·L−1 6-BA + 30.0 g·L−1 sucrose + 3.8 g·L−1 gellan gum) for 21 days. The callus growth was cultured in a liquid growth medium (MS + 5.37 μmol·L−1 NAA + 13.32 μmol·L−1 6-BA + 30.0 g·L−1 sucrose) with an initial inoculation amount of 40 g·L−1, a shaking speed of 110 r/min and darkness. Cell growth was fastest with a culture period of 21 days. We replaced the growth medium with the production medium (MS + 5.37 μmol·L−1 NAA + 13.32 μmol·L−1 6-BA + 30.0 g·L−1 glucose) for maximum accumulation of total saponins. [Conclusion] A callus induction and suspension culture system for the root of P. japonicus was established. In this way, we can promote the accumulation of total saponins in callus cells and provide a basis for large-scale cell culture and industrial production of medicinal total saponins.
Plasma Treatment of Nanocellulose to Improve the Surface Properties
Authors: Primc Gregor , Mozetič Miran
Published: September 2024

Nanocellulose is among the most promising materials for enhancing the mechanical properties of polymer composites. Broad application is, however, limited by inadequate surface properties. A standard technique for tailoring the surface composition and wettability of polymers is a brief treatment with non-equilibrium gaseous plasma, but it often fails when treating materials with a large surface-to-mass ratio, such as cellulose nanofibers. In this paper, the theoretical limitations are explained, the approaches reported by different groups are reviewed, and the results are interpreted. The treatment of dry nanocellulose is limited by the ability of uniform treatment, whereas the plasma treatment of nanocellulose dispersed in liquids is a slow process. The methods for enhancing the treatment efficiency for both dry and water-dispersed nanocellulose are explained.
Exploring the Effect of In Vitro Aging Protocols on the Optical Properties and Crystalline Structure of High-Translucency (HT) Zirconia Used in Dentistry: A Systematic Review
Authors: Al-Hourani Zeid A. , Hatamleh Muhanad M. , Alqaisi Obada A.
Published: September 2024

Zirconia crowns are capping materials used in dentistry for tooth capping and are very popular due to their optical properties and natural-looking visuals. In vitro aging protocols measure zirconia’s optical properties, which are vital in order for it to look natural. This study aims to conduct a systematic review to explore the effect of in vitro aging protocols on the optical properties and crystalline structure of high-translucency (HT) zirconia. A correlation matrix was obtained using Microsoft Excel, which was later transferred into SPSS for confirmatory factor analysis (CFA) and hierarchal clustering and to obtain a dendrogram in order to display the distribution of clusters for each key term relevant to the study. Further, for qualitative analysis, 17 studies were screened and reviewed. The result demonstrates that high translucency has been observed in the crystalline structure of zirconia capping. However, quantitative and qualitative results did not demonstrate the in vitro protocol; instead, neglect of the in vitro protocol’s vitality in zirconia crown capping was alarming. Overall, zirconia has good optical properties when combined with catalysts such as aluminum and lithium to obtain a more sustainable crystalline structure.
Improving Angle-Only Orbit Determination Accuracy for Earth–Moon Libration Orbits Using a Neural-Network-Based Approach
Authors: Zhang Zhe , Shi Yishuai , Zheng Zuoxiu
Published: September 2024

In the realm of precision space applications, improving the accuracy of orbit determination (OD) is a crucial and demanding task, primarily because of the presence of measurement noise. To address this issue, a novel machine learning method based on bidirectional long short-term memory (BiLSTM) is proposed in this research. In particular, the proposed method aims to improve the OD accuracy of Earth–Moon Libration orbits with angle-only measurements. The proposed BiLSTM network is designed to detect inaccurate measurements during an OD process, which is achieved by incorporating the least square method (LSM) as a basic estimation approach. The structure, inputs, and outputs of the modified BiLSTM network are meticulously crafted for the detection of inaccurate measurements. Following the detection of inaccurate measurements, a compensating strategy is devised to modify these detection results and thereby reduce their negative impact on OD accuracy. The modified measurements are then used to obtain a more accurate OD solution. The proposed method is applied to solve the OD problem of a 4:1 synodic resonant near-rectilinear halo orbit around the Earth–Moon L2 point. The training results reveal that the bidirectional network structure outperforms the regular unidirectional structures in terms of detection accuracy. Numerical simulations show that the proposed method can reduce the estimated error by approximately 10%. The proposed method holds significant potential for future missions in cislunar space.
GA-BP-Based Low-Noise FBG Hydroacoustic Monitoring System with Reference Sensor
Authors: Zhou Yubin , Zhao Yuexia , Song Chengbing , Wang Jiancun , Xu Weikun , Li Zhengguang
Published: September 2024

To address the issue of harsh marine background noise impacting the monitoring signal of fiber-optic hydrophones, we propose a low-noise fiber Bragg grating (FBG) hydroacoustic monitoring system with a reference sensor based on genetic algorithm backpropagation (GA-BP). Through theoretical analysis, we deduce the noise suppression steps of the GA-BP algorithm based on the reference sensor and construct train and test sets based on the data from the reference sensor and monitoring sensor at different times, optimizing the GA-BP algorithm to find the best fitting results and thereby obtaining the low-noise monitoring signal. Experimental results from the anechoic tank show that the proposed method can suppress background noise interference on effective signals and that the suppression effect improves as the background noise increases. The sound pressure sensitivity ranges from −173.76 dB to −171.33 dB at frequencies of 8 kHz to 12 kHz, with a response flatness of less than 2.43 dB. The noise suppression effect is obvious under the condition of poor signal-to-noise ratio (SNR), which can reach more than 18.3 dB. The advantages of the proposed algorithm in array signal processing are further demonstrated by the directivity experiment, which proves that the algorithm has a great potential for engineering applications in harsh marine environment.
Error Analysis and Optimization of Structural Parameters of Spatial Coordinate Testing System Based on Position-Sensitive Detector
Authors: Lu Haozhan , Chu Wenbo , Zhang Bin , Zhao Donge
Published: September 2024

For the research on real-time accurate testing technology for the explosion point spatial coordinate of munitions, its currently commonly used methods such as acoustic–electric detection or high-speed imaging are limited by the field conditions, response rate, cost, and other factors. In this paper, a method of spatial coordinate testing for the explosion point based on a 2D PSD (position-sensitive detector) intersection is proposed, which has the advantages of a faster response, better real-time performance, and a lower cost. Firstly, a mathematical model of the spatial coordinate testing system was constructed, and an error propagation model for structural parameters was developed. The influence of the position of the optical axes’ intersection as well as the azimuth angle and pitch angle on the test accuracy of the system was simulated and analyzed, thus obtaining the distribution and variation trend of the overall error propagation coefficient of the system. Finally, experiments were designed to obtain the test error of the system for validation. The results show that the system test accuracy is high when the azimuth angle is 20°–50°, the overall error propagation coefficient does not exceed 48.80, and the average test error is 56.17 mm. When the pitch angle is −2.5°–2.5°, the system has a higher test accuracy, with the overall error propagation coefficient not exceeding 44.82, and the average test error is 41.87 mm. The test accuracy of the system is higher when the position of the optical axes’ intersection is chosen to make sure that explosion points fall in the region of the negative half-axis of the Zw-axis of the world coordinate system, with an overall error propagation coefficient of less than 44.78 and an average test error of 73.38 mm. It is shown that a reasonable selection of system structure parameters can significantly improve the system test accuracy and optimize the system deployment mode under the long-distance field conditions so as to improve the deployment efficiency.
Nanoporous Gold-Modified Screen-Printed Electrodes for the Simultaneous Determination of Pb2+ and Cu2+ in Water
Authors: Li Yongfang , Chen Xuan , Yuan Zhiyong , Yi Zhijian , Wang Zijun , Wang Rui
Published: September 2024

In this study, nanoporous gold (NPG) was deposited on a screen-printed carbon electrode (SPCE) by the dynamic hydrogen bubble template (DHBT) method to prepare an electrochemical sensor for the simultaneous determination of Pb2+ and Cu2+ by square wave anodic stripping voltammetry (SWASV). The electrodeposition potential and electrodeposition time for NPG/SPCE preparation were investigated thoroughly. Scanning electron microscopy (SEM) and energy-dispersive X-ray diffraction (EDX) analysis confirmed successful fabrication of the NPG-modified electrode. Electrochemical characterization exhibits its superior electron transfer ability compared with bare and nanogold-modified electrodes. After a comprehensive optimization, Pb2+ and Cu2+ were simultaneously determined with linear range of 1–100 μg/L for Pb2+ and 10–100 μg/L for Cu2+, respectively. The limits of detection were determined to be 0.4 μg/L and 5.4 μg/L for Pb2+ and Cu2+, respectively. This method offers a broad linear detection range, a low detection limit, and good reliability for heavy metal determination in drinking water. These results suggest that NPG/SPCE holds great promise in environmental and food applications.
An Electrochemical Nucleic Acid Biosensor for Triple-Negative Breast Cancer Biomarker Detection
Authors: Hansen Lexi , Nagdeve Sanket Naresh , Suganthan Baviththira , Ramasamy Ramaraja P.
Published: September 2024

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, affecting younger women and women of minorities. The nomenclature “triple negative” is derived from the absence of the three most common breast cancer biomarkers: progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2). It derives its name from testing negative for these three most common breast cancer biomarkers. Currently, TNBC is diagnosed at advanced stages, necessitating the need for a diagnostic tool or method to identify this malignancy at an early stage prior to metastasis. In this study, a novel electrochemical biosensor was developed, optimized, and evaluated for the detection of microRNA-10b (miRNA-10b), marking the first use of this biomarker for the early diagnosis of TNBC. The biosensor demonstrated the ability to detect concentrations as low as 10 pM. Furthermore, the biosensor was specific toward the target biomarker, distinguishing non-target miRNAs of similar size. The efficacy of the biosensor for TNBC early diagnosis was further validated using human serum samples.
Deep Integration of Fiber-Optic Communication and Sensing Systems Using Forward-Transmission Distributed Vibration Sensing and on–off Keying
Authors: Zhu Runlong , Rao Xing , Dai Shangwei , Chen Ming , Liu Guoqiang , Liu Hanjie , Xu Rendong , Chen Shuqing , Chen George Y. , Wang Yiping
Published: September 2024

The deep integration of communication and sensing technology in fiber-optic systems has been highly sought after in recent years, with the aim of rapid and cost-effective large-scale upgrading of existing communication cables in order to monitor ocean activities. As a proof-of-concept demonstration, a high-degree of compatibility was shown between forward-transmission distributed fiber-optic vibration sensing and an on–off keying (OOK)-based communication system. This type of deep integration allows distributed sensing to utilize the optical fiber communication cable, wavelength channel, optical signal and demodulation receiver. The addition of distributed sensing functionality does not have an impact on the communication performance, as sensing involves no hardware changes and does not occupy any bandwidth; instead, it non-intrusively analyzes inherent vibration-induced noise in the data transmitted. Likewise, the transmission of communication data does not affect the sensing performance. For data transmission, 150 Mb/s was demonstrated with a BER of 2.8 × 10−7 and a QdB of 14.1. For vibration sensing, the forward-transmission method offers distance, time, frequency, intensity and phase-resolved monitoring. The limit of detection (LoD) is 8.3 pε/Hz1/2 at 1 kHz. The single-span sensing distance is 101.3 km (no optical amplification), with a spatial resolution of 0.08 m, and positioning accuracy can be as low as 10.1 m. No data averaging was performed during signal processing. The vibration frequency range tested is 10–1000 Hz.
A Nationwide Exploration of Knowledge and Attitudes toward the Abuse of Older Individuals: A Cross-Sectional Study among the General Population of the Republic of Croatia
Authors: Skupnjak Dino , Neuberg Marijana , Obranić Sonja , Meštrović Tomislav
Published: September 2024

Understanding the frequency of abuse suffered by older individuals proves challenging when attempting to link it to everyday social issues due to variations in the interpretation and comprehension of this form of mistreatment. This cross-sectional study conducted in May and June of 2023 aimed to investigate the perceptions and attitudes of the general population in the Republic of Croatia regarding the abuse of older individuals. The research included 822 volunteers aged from 18 to 64 who actively engaged in social media. A self-developed, structured questionnaire (based on an exhaustive review of the relevant literature) that underwent a thorough pilot testing phase to confirm clarity, coherence, and respondent comprehension was used to collect the study data. The data analysis included descriptive statistics, chi-square tests for associations between variables, and Mann–Whitney U and Kruskal–Wallis tests to assess the relationships between correct answers and observed indicators, with a significance level set at p < 0.05 (two-tailed). It can be concluded that there was a statistically significant difference in knowledge of possible causes of abuse depending on the age groups of the respondents (p = 0.001) and their present employment within the health or social system (p < 0.001). A prevailing neutral stance was observed among the majority of the surveyed population regarding the attribution of responsibility to older individuals themselves for any mistreatment they face. When confronted with scenarios illustrating abusive behaviour towards older individuals, the participants exhibited nuanced recognition across different forms of abuse, with the exception of financial abuse, where most participants indicated that there was no abuse or possible abuse. These findings underscore the need for enhanced public education initiatives concerning the diverse manifestations of abuse and neglect within the community of older individuals in the Republic of Croatia. Additionally, there is a pressing need for counselling services aimed at fostering a deeper understanding of the unique needs of older individuals and the underlying factors contributing to abusive behaviour. Through such measures, societal awareness and support mechanisms can be fortified, fostering a culture of respect, empathy, and protection for older adults.
Socio-Economic Determinants of Greenhouse Gas Emissions in Mexico: An Analytical Exploration over Three Decades
Authors: Escamilla-García Pablo Emilio , Rivera-González Gibran , Rivera Angel Eustorgio , Soto Francisco Pérez
Published: September 2024

Greenhouse gas (GHG) emissions have become a critical environmental issue with significant implications for global climate change. Understanding the factors that influence GHG emissions is essential for developing effective mitigation strategies. This study focuses on Mexico, a country that has experienced substantial economic and social changes over the past two decades. The primary objective was to analyze the impact of various economic and social variables on GHG emissions in Mexico using correlation and Vector Autoregression (VAR) analysis. The variables under consideration included Gross Domestic Product (GDP), energy consumption, population, per capita income, income inequality (measured by the Gini coefficient), and educational levels. Results showed that GDP, energy consumption, and population are positively correlated with GHG emissions and negatively correlated with income inequality. The Granger causality analysis showed that GDP and per capita income are strong predictors of GHG emissions; in contrast, income inequality and educational levels do not exhibit direct causative impacts on emissions. Finally, it was found that higher educational levels may contribute to lower GHG emissions. With this evidence, climate policies in Mexico can be formulated by addressing key areas, and policymakers can design strategies that effectively manage and reduce GHG emissions, aligning with sustainable development goals and mitigating the adverse effects of climate change.
Blockchain-Based Decentralized Storage Systems for Sustainable Data Self-Sovereignty: A Comparative Study
Authors: Merlec Mpyana Mwamba , In Hoh Peter
Published: September 2024

In the digital age, data sovereignty has emerged as a critical concern due to the increasing demand for privacy, security, and user control. In this context, decentralized storage infrastructure is reshaping how data are stored and managed, leading the transition from traditional centralized models to a more decentralized and user-driven approach to data sovereignty, known as data self-sovereignty (DSS). This paper presents a systematic comparative analysis of decentralized storage systems, emphasizing their potential to enhance sustainable DSS. By highlighting the integral role of blockchain technology, this study critically examines various decentralized storage platforms, including Arweave, BitTorrent, Dat Protocol, Filecoin, Hypercore Protocol, IPFS, MaidSafe, Sia, Storj, and Swarm. The analysis covers the key architectural features of these systems, their performance metrics, and their contribution to user data sovereignty. This study aims to comprehensively explain how these decentralized storage solutions allow users to maintain complete control over their data, thus offering a viable alternative to traditional centralized storage methods. Therefore, This paper contributes to ongoing data sovereignty research and guides future developments in decentralized storage technologies.
The Interplay of Environmental Dynamism, Digitalization Capability, Green Entrepreneurial Orientation, and Sustainable Performance
Authors: Liang Yi , Koo Jung-Mo , Lee Min-Jae
Published: September 2024

The purpose of this study is to understand the interplay between environmental dynamism, digitalization capability, green entrepreneurial orientation, and sustainable performance by using contingency theory and the dynamic capabilities perspective as a comprehensive theoretical lens. More specifically, this study examines the impact of environmental dynamism on the development of digitalization capability and verifies the mediating role of green entrepreneurial orientation between digitalization capability and sustainable performance. As a result of analyzing 450 Chinese manufacturing firms, it was confirmed that environmental dynamism had a significant positive effect on the development of digitalization capability. In addition, the partial mediation effect of green entrepreneurial orientation on digitalization capability and sustainable performance was also identified. This indicates that firms with a green entrepreneurial orientation can better achieve sustainable development through digitalization capability. As a result, this study provides important implications for promoting sustainable development in both the literature and practice and also presents a contribution to current knowledge.
Optimizing Cross-Regional Lockdown Policies for Epidemics: Balancing Economic and Public Health Costs
Authors: Qin Taojie , Gan Xianghua , Li Yuchen , Qin Changsheng
Published: September 2024

The cross-regional spread of epidemics, such as COVID-19, poses significant challenges due to the spillover of false-negative individuals resulting from incubation periods, detection errors, and individual irrationality. This study develops a stylized model to address the trade-offs faced by the planner in designing optimal lockdown policies: curbing the cross-regional spread of epidemics while balancing economic costs and ensuring long-term sustainability. The model integrates a queuing network to calculate the influx of false-negative cases, which more accurately reflects real-world scenarios and captures the complexity of regional interactions during an outbreak. Subsequently, a SIR network is used to estimate the spread of infections. Unlike similar studies, our approach focuses specifically on the cross-regional dynamics of epidemic spread and the formulation of optimal lockdown policies that consider both public health and economic impacts. By optimizing the lockdown threshold, the model aims to minimize the total costs associated with lockdown implementation and infection spread. Our theoretical and numerical results underscore the crucial role of timely nucleic acid testing in reducing infection rates and highlight the delicate balance between public health benefits and economic sustainability. These findings provide valuable insights for developing sustainable epidemic management strategies.