bluuebunny/crossref_metadata_2025 huggingface dataset:
Hadamard product of holomorphic mappings associated with the conic shaped domain
Authors: HUSSAİN BUKHARİ Syed Zakar , SHAHZAD Aamir
Published: March 2023

We define certain subclasses $\delta-\mathcal{UM}(\ell,\eta_{1},\eta_{2})$ and
$\delta-\mathcal{UM}_{\Im}(\ell,\eta_{1},\eta_{2})$ of holomorphic mappings
involving some differential inequalities. These functions are actually
generalizations of some basic families of starlike and convex mappings. We
study sufficient conditions for $f\in \delta-\mathcal{UM}(\ell,\eta_{1}%
,\eta_{2}).$ We also discuss the characterization for $f\in \delta
-\mathcal{UM}_{\Im}(\ell,\eta_{1},\eta_{2})$ along with the coefficient bounds
and other problems. Using certain conditions for functions in the class
$\delta-\mathcal{UM}(\ell,\eta_{1},\eta_{2}),$ we also define another class
$\delta-\mathcal{UM}^{\ast}(\ell,\eta_{1},\eta_{2})$ and study some
subordination related result.
Free resolutions for the tangent cones of some homogeneous pseudo symmetric monomial curves
Authors: ŞAHİN Nil
Published: March 2023

In this article, we study minimal graded free resolutions of Cohen-Macaulay tangent cones of some monomial curves associated to 4-generated pseudo symmetric numerical semigroups. We explicitly give the matrices in these minimal free resolutions.
Quantum Entanglement in a Context of Creation Theology
Authors: Кирьянов Д.
Published: March 2023

В статье изучается роль феномена квантовой запутанности в современном диалоге науки и богословия. Философское осмысление квантовой запутанности и нелокальных связей может быть осуществлено в рамках онтологии реляционного холизма. Реляционный холизм может быть интерпретирован в контексте православного богословия творения как отражение особого отношения тварного мира с Творцом, нашедшего характерное выражение в богословии прп. Максима Исповедника и свт. Григория Паламы. Реляционно-холистическое понимание тварного мира предполагает возможность его объяснения в контексте тринитарного понимания Бога в православной традиции и подчёркивает созвучие между научным и богословским пониманием мироздания.
Developments in the Liturgical Life of the Savior Transfiguration Valaam Monastery in 1830s
Authors: Сергеев Г.Б.
Published: March 2023

В настоящей статье рассматриваются изменения в литургической жизни Валаамской обители, происходившие в 1833-1839 гг. - при игумене Вениамине (Мануйлове), а также отношение к этим изменениям со стороны монастырской братии и священноначалия, в частности тогдашнего благочинного монастырей Санкт-Петербургской епархии свт. Игнатия (Брянчанинова). Дабы показать реальные изменения в богослужебной жизни обители, возражения братии, ревновавшей о сохранении устава, и заключение высшей церковной власти, автор опирается на документы архивных фондов Святейшего Синода и Санкт-Петербургской Духовной консистории. Для рассмотрения литургической жизни монастыря привлекается исторический контекст, иллюстрирующий то, как различные факторы могут влиять на восприятие братией изменений в богослужении. По итогам исследования делается вывод: поскольку богослужение является сердцевиной жизни монашеской общины, постольку незначительные, с точки зрения общего устава, перемены в порядке совершения служб не должны сопровождаться ощутимым смущением и разделением среди братии, какими бы законными эти перемены ни были. Более того, из истории Валаамского монастыря можно видеть, что не все кажущиеся необходимыми изменения действительно оказываются таковыми по прошествии некоторого времени, а также после принятия иных, более уместных в конкретной ситуации решений.

Abstract In the present article the changes in the liturgical life of the Valaam monastery, happened in the reign of heg. Benjamin (Manuilov; 1833-1839), also the relation to them of the monastery brotherhood and the hierarchy - particularly of then rural dean of the St.-Petersburg eparchy monasteries st. Ignatius (Brianchaninov) - are reviewed. To show the real changes in the worship life of the monastery, the objections of the brotherhood being zealous of the monastic rules conservation and the hierarchy conclusion the author leans on the documents of the Holy Synod and St.-Petersburg Consistory archival collections. When considering the monastery liturgical life issue the historical context is involved, illustrating how the various factors can affect the perception of the changes in the worship by the brotherhood. As a research result the conclusion is drawn: as the worship is the heart of the monastic community life, so the insigni cant, from the point of view the church discipline, changes in the services performance order shouldn’t be accompanied by the appreciable confusion and division among the brotherhood, however legal these changes are. Moreover, from the history of the Valaam monastery man can see that not all changes seeming necessary prove to be such after some time has elapsed, as well as after the different, more appropriate in the concrete case solutions.
Metropolitan Districts and Metropolises in the Recent History of the Russian Orthodox Church
Authors: Звонарёв С.
Published: March 2023

Церковные области, созданные в Русской Православной Церкви в 1928 и 1934 годах, долго не просуществовали, а потому не оказали заметного влияния на церковную жизнь. Однако идея окружного объединения нескольких епархий не была позабыта. С появлением благоприятных условий она получила новое развитие уже в наши дни в проекте создания митрополичьих округов и митрополий. Целью предлагаемого читателю текста небольшого исследования, завершающего трилогию статей автора на тему церковных округов, является сопоставление статуса, полномочий органов управления митрополичьих округов и митрополий, в том числе применительно к опыту конструирования региональных церковных центров столетней давности. Для достижения цели используется метод сравнительного исторического и церковно-правового анализа. Созданные экспертами и церковным законодателем территориальные канонические структуры в виде митрополичьих округов и митрополии как формы объединения нескольких епархий стали уникальным в своём роде опытом проектирования региональных церковных центров. Выйдя за пределы пастырско-миссионерских задач, что являлось константой всего предшествующего опыта построения окружного митрополичьего управления, современные митрополичьи округа наделены административно-судебными полномочиями, а митрополии - административными. Как это проявилось в деталях конструкции региональных церковных центров, мы рассмотрим ниже.

The Church areas created in the Russian Orthodox Church in 1928 and 1934 did not exist long, and therefore did not have a noticeable impact on Church life. However, the idea of creating Church areas which united several dioceses was not forgotten. With the appearance of favorable conditions, nowadays this idea received a new development in the project of creating metropolitan areas and metropolias. The purpose of this article is to compare the status and powers of the governing bodies of metropolitan areas and metropolias, including the experience of creating regional Church centers a century ago. To achieve this goal, the method of comparative historical and сhurch-legal analysis was used. The territorial canonical structures created by experts and the Church legislator in the form of metropolitan areas and metropolias by uni cation of several dioceses have become a unique experience in designing regional Church centers. Having gone beyond the limits of pastoral and missionary tasks, which was a constant of all previous experience in building metropolitan areas administrations, modern metropolitan areas are endowed with administrative and judicial powers, and metropolias with administrative powers. In this work we are going to consider how this manifested itself in the details of the construction of regional Church centers.
Selling space at the monastery and making economic sense of the ‘intrusive’ at monastic sites in Gandhāra
Authors: Schopen Gregory
Published: March 2023

It is not often that a single short text might account for a whole series of different things that can be seen at a number of actual monastic sites in Greater Gandhāra – at Taxila, Butkara, Loriyān Tangai, Takht-i-Bāhī, for example – but also at widely scattered and distant sites like Ajaṇṭā and Kānheri, or Ratnagiri or Udayagiri in the South. But that might very well be the case in regard to a little text tucked away in the enormous Mūlasarvāstivāda-vinaya, a monastic Code of more than 4,000 folios that appears to have been redacted or compiled in North India in the Kushan Period. This might suggest that we start in North India or Gandhāra, and yet starting elsewhere at far away Ajaṇṭā may provide a concept that may be useful in talking about what can be seen at Taxila, and it is probably true that Gandhāra is far too often studied in isolation.
Does iconography really matter? Iconographical specification of Buddha images in pre-esoteric Buddhist art
Authors: Rhi Juhyung
Published: March 2023

Identifying a figure or character is a rudimentary step in reading a visual image, but it is an indispensable foundation for a variety of more sophisticated investigations and interpretations. For Buddhist art specialists as well, identifying various divinities represented in visual images has been a major preoccupation. This task, commonly referred to as ‘iconography’, is sometimes quite straightforward but sometimes not so simple, owing to the inconsistency of visual evidence or its incongruence with literary stipulations, or the lack of sufficient specificity. Its difficulty also often varies in different classes of divinities. Minor deities are in general more easily identifiable from their idiosyncratic appearances. Bodhisattvas are often distinguishable from their special attributes but equally often pose problems, as I argued in a recent publication (Rhi 2018b). However, Buddhas are more difficult or more confusing in identification because of the lack of complexity in their appearance. They generally look alike despite minor differences, which are rarely indicative of separate identities. Art history students may be taught the possibility of distinguishing Buddhas according to hand gestures (mudrā) or attendant figures, but this method in fact works only in a limited range of instances. In reality, Buddhas were made in indistinguishable shapes throughout most regions in the Buddhist world at least in the pre-esoteric period. This paper will explore this phenomenon in India, especially focusing on Gandhāra, and attempt to seek its ramifications for understanding the significance of Buddha images in India and other parts of Asia in the pre-esoteric phase.
Early Gandhāran art: artists and working processes at Saidu Sharif I
Authors: Olivieri Luca M.
Published: March 2023

The Festschrift published in 2006 by Pierfrancesco Callieri to celebrate Domenico Faccenna’s eightieth birthday (Callieri 2006), represented an important novelty amongst the studies on Gandhāra and Hellenistic Asia. In fact, for ancient Indian art and architecture, and Gandhāra in particular, studies on stone-processing techniques, organization of building sites, guilds of craftsmen (apart from epigraphic and textual documentation), were (and still are) rare. This is why I attempted to present a reconstruction of the working process at Saidu Sharif I in a recent study (Olivieri 2022a). The latter, I hope, will be considered more as a practical working model for future studies than for the hypotheses it contains. That study is based on Faccenna’s (1995; 2001) data, to which I have added other, new data, from the excavations I directed at the Buddhist sanctuary of Saidu Sharif I from 2011 to 2014 (henceforth abbreviated as Saidu). From that study originates much of what follows, which focuses on the early phases of the Saidu sanctuary (c. second half of the first century AD, period Ia).
Buddhist art of Gandhāra: a catalogue of newly documented sites in Malakand District
Authors: Naz Fozia
Published: March 2023

In respect to Gandhāra civilization, antiquarians and archaeologists have made many discoveries in ancient Uḍḍiyāna (Swat) and the present-day Khyber Pakhtunkhwa region of Pakistan. Historically and geographically, ancient Uḍḍiyāna (Swat) occupies an important position in South and Central Asia. From the nineteenth century, archaeological explorations have entailed surveys and excavations of many sites within the confines of Uḍḍiyāna (Faccenna 1980; Stacul 1989; Callieri 2005). These sites included structural remains and cultural artefacts, consisting of pottery, coins, Buddhist sculptures, decorated stone fragments, and jewelry. The region remains rich in archaeological evidence for the explanation of the Buddhist period. The district of Malakand is one of the most important valleys among the archaeological sites of the Gandhāra region. Many examples of Buddhist-period rock art have also been reported there and their relevance to Gandhāran art has been discussed in previously published survey results (Naz 2020; Naz and Sardar 2021). The present paper will summarize Buddhist art recorded from different sites in Malakand District (Map 1). A newly documented Muslim-period graveyard with abundant, reused Buddhist sculptural fragments is also included in this article. The Gandhāran art collections in Swat, Peshawar and Chakdara Museums are not included in this paper.
A preliminary investigation of what occupational science is doing
Authors: Turnbull David , Barnard Ross
Published: March 2023

We examine the case of a relatively new discipline, occupational science (founded in 1989). The aim is to come to a very general understanding of what occupational science is doing. This preliminary investigation paves the way for more specific inquiries into directions in occupational science research. The present aim requires us to focus on two sorts of experiential knowledge - phenomenological and empirical - the conceptual overlap of which occurs _in occupational science itself_. It is claimed that there is a need for conceptual clarification, particularly given that occupational science claims to be holistic. We turn to examine the various _meanings of occupation_, as they occur in this discipline. We then examine the particular legacy of Ann Wilcock, paying particular attention to her claim that occupation, conceived as a synthesis of doing, being, becoming and belonging, is essential to survival and health.
On the statistical arrow of time
Authors: Henriksson Andreas
Published: March 2023

What is the physical origin for the arrow of time? It is a commonly held belief in the physics community that it relates to the increase of disorder, or entropy, as it appears in the statistical interpretation of the second law of thermodynamics. In this article, it is argued that the philosophical point of view that the arrow of time is a fundamental property of Nature is incompatible with the subjective information-theoretical interpretation of probability and entropy in statistical mechanics, where they arise due to the ignorance of the observer. This conclusion, however, relies on the premise that time's arrow has a statistical mechanical origin. If this assumption is abandoned, then there is no conflict between the belief in the fundamental character of time's arrow and the belief in the subjective information-theoretical interpretation.
The psychological ability to perceive the world in conditions of danger
Authors: Tsurkan-Saifulina Y.
Published: March 2023

The relevance of the study is determined by the stage of active changes in the modern world in the context of the global coronavirus pandemic in recent years, and for Ukrainian society, the introduction of martial law due to the aggression of a neighbouring country, as a result of which Ukrainians experience a sense of danger and an uncertain future, financial instability in difficult-to-control life circumstances that affect personal development. Therefore, the purpose of this research work is to determine and identify the psychological ability of a person to use personal resources to overcome difficulties in conditions of danger, to adapt, and to develop positive attitudes and skills during stressful and crises. The theoretical and methodological foundation of the study is conditioned upon the generalisation of many years of experience in exploring human psychological states, namely, the frustration of the individual in conditions of danger and the possibilities of adaptation to current living conditions. An important tool for exploring the subject was a survey conducted among internally displaced persons and people who did not leave their homes during the war. The research presents results that reflect partial apperception due to the isolation of people in previous years due to the pandemic and, as a result, the successful constructive experience of overcoming the new crisis, the individual’s adaptability and desire to overcome circumstances and generating conscious behaviour in times of danger. The results obtained can be used in further scientific research on the issue of a person’s psychological ability to perceive the world in conditions of danger, and for practical purposes.
Traditions and innovations in Ukrainian jurisprudence: Ancient Greek roots
Authors: Vandzhurak R.
Published: March 2023

Ukraine’s course toward European integration requires harmonisation of Ukrainian legislation with European law, which has its origins in the cultural and traditional foundations of the ancient era. Therefore, the research on the influence of the ancient Greek philosophy of law on the development of Ukrainian jurisprudence becomes relevant, and in the course of this, the problem of the clash of traditions of different legal families and areas of development of legal innovations arises. The purpose of this study – to identify the factor of the dialectic of traditions and innovations in Ukrainian jurisprudence as one of the driving factors of its development. The author uses the methods of axiological analysis, comparative legal method and the method of analogy to substantiate the results obtained and develop conclusions. As a result of the research, it was established that no matter how modified the forms of key legal values, doctrines and institutions are, they are always based on the fundamental ideas based on the intellectual traditions and philosophical and legal ideas of the thinkers of Ancient Greece. It is evidenced by the universalist approach they initiated, on which all European science (including legal science) is based, and modern anthropological concepts of law understanding in general and the justification of fundamental human rights, in particular, are based on principles genetically rooted in the teachings of Protagoras, Socrates and Aristotle. Therewith, it was established that the latest achievements in the organisation of democratic governance are focused on the implementation of the ancient Greek idea of democracy. The author demonstrates that in the dialectical process of development of any legal system, there is always an interaction of some established (traditional) components and various new developments conditioned upon the specifics of such development at each stage, and concludes that the time-influenced changeability of legal values, doctrines and institutions goes back to the intellectual tradition and philosophical and legal ideas of the thinkers of the Ancient period. The practical significance of this research is that the materials of the study can be used: in lawmaking – for the preparation and substantiation of draft laws on the further development of the legal system of Ukraine; in the educational process and research work – in teaching relevant disciplines.
Keikutsertaan Masyarakat Muslim dalam Upacara Tiwah Agama Hindu Kaharingan di Kota Palangka Raya
Authors: Helim Abdul , Tiara Syahriana Unggun
Published: March 2023

This study tries to answer on kinds of things followed by Dayak Ngaju Tribe Muslim Community Palangka Raya city in Tiwah Ceremony of Hindu Kaharingan and the reasons why they participate on the ceremony. This problem is studied by qualitative description by using cultural and religious approaches. The study results find out that most of Muslim community only participate some series of tiwah ceremony considered to be still tolerated by Islam, meanwhile for some other small parts, they still participated on them but they just do it not by full-hearted.  Their participation on the tiwah ceremony is as a honor for their parents and family having their own history in their life. The participation model of Dayak Ngaju Tribe Muslim Community which is only in still tolerated things in Islam activities can be considered as the local Islamic tradition.
Tindak Pidana Kekerasan Psikis Dalam Rumah Tangga Anak Kepada Orang Tua, dan Perbedaaan Dengan Penghinaan Menurut KUHP (Studi Putusan Pengadilan Tinggi Jakarta Nomor: 168/PID/2020/PT.DKI)
Authors: Nur Adima Fauzan
Published: March 2023

Undang-Undang 23 tahun 2004 Tentang Penghapusan Kekerasan Dalam Rumah Tangga kaitanya bukan hanya kesetaraan gender antara laki-laki dan perempuan. Kesetaraan harus didapatkan oleh setiap anggota keluarga suami, isteri dan anak, seperti dalam kasus ini terjadi kdrt secara psikis oleh anak terhadap orang tua yang mengakibatkan depresi. Penelitian ini bertujuan untuk memberikan gambaran tentang bagaimana Analisa terhadap pertimbangan hakim terhadap KDRT Psikis. Dengan metode penelitian Yuridis-Normatif. Pertimbangan hakim telah tepat dengan mempertimbangkan alat-alat bukti yang diajukan oleh penuntut umum.
THAWAF IFADHAH BAGI PEREMPUAN HAID
Authors: Wisnarni Wisnarni
Published: March 2023

Pelaksanaan tawaf ifadhah harus dilakukan dalam keadaan suci. Sehingga Nabi saw. melarang wanita haid melaksanakan tawaf. Terjadi perbedaan pendapat dikalangan ulama dalam menanggapi hal ini, pertama menurut jumhur wanita yang mengalami haid ketika musim haji harus menunggu hingga suci untuk dapat melaksanakan tawaf ifadhah.  Kedua  ulama mazhab hanafi berpendapat bahwa suci akan merupakan syarat sah tawaf ifadhah, sehingga diperbolehkan bagi wanita haid untuk melaksanakan tawaf dengan catatan harus menimpalinya dengan membayar dam.
RUANG LINGKUP KAJIAN USHUL FIQH
Authors: Repelita Repelita
Published: March 2023

Ruang lingkup ushul fiqh menurut al-Ghazali dan al-Syatibi, tidak terlalu banyak berbeda. Terkecuali hanya kajian maqashid al-syari’ah dan ringkasan dalil-dalil syari’ah (al-adillah al-Syari’iyyah) oleh asy-Syatibi. Namun demikian, ada kemungkinan kajian maqashid al-syari’ah asy-Syatibi merupakan penjabaran konsep ishtishlah al-Ghazali. Yakni, syari’at itu diturunkan dengan tujuan untuk melindungi agama, jiwa, akal, keluarga dan apa yang dimiliki manusia.
PENGARUH RISIKO PEMBIAYAAN DAN RISIKO LIKUIDITAS TERHADAP PROFITABILITAS BANK UMUM SYARIAH PERIODE 2018-2020
Authors: Habriyanto Habriyanto , Khairiyani Khairiyani , Alfaruq Muhammad Amir
Published: March 2023

This study aims to examine the effect of financing risk and liquidity risk on the profitability of Islamic commercial banks for the 2018-2020 period. The sampling technique used is purposive sampling. The sample used is a Sharia Commercial Bank registered with the Financial Services Authority (OJK). Based on the purposive sampling method, 11 Islamic Commercial Banks meet the criteria. The results of this study indicate that partial liquidity risk does not affect the profitability of Islamic commercial banks. In contrast, financing risk influences the profitability of Islamic commercial banks. This study also shows that financing and liquidity risks simultaneously affect Islamic commercial banks' profitability. Based on the calculations carried out in this study, the results showed that the financing risk level could affect Islamic commercial banks' profitability.
Debiasing and Educational Interventions in Medical Diagnosis: A Systematic Review
Authors: Tung Arthur , Melchiorre Michael
Published: March 2023

Background: The prevalence of cognitive bias and its contribution to diagnostic errors has been documented in recent research. Debiasing interventions or educational initiatives are key in reducing the effects and prevalence of cognitive biases, contributing to the prevention of diagnostic errors. The objectives of this review were to 1) characterize common debiasing strategies implemented to reduce diagnosis-related cognitive biases, 2) report the cognitive biases targeted, and 3) determine the effectiveness of these interventions on diagnostic accuracy. 
Methods: Searches were conducted on April 25, 2022, in MEDLINE, EMBASE, Healthstar, and PsycInfo. Studies were included if they presented a debiasing intervention which aimed to improve diagnostic accuracy. The Rayyan review software was used for screening. Quality assessments were conducted using the JBI Critical Appraisal Tools. Extraction, quality assessment and analysis were recorded in Excel.
Results: Searches resulted in 2232 studies. 17 studies were included in the final analysis. Three major debiasing interventions were identified: tool use, education of biases, and education of debiasing strategies. All intervention types reported mixed results. Common biases targeted include confirmation, availability, and search satisfying bias.
Conclusion: While all three major debiasing interventions identified demonstrate some effectiveness in improving diagnostic accuracy, included studies reported mixed results when implemented. Furthermore, no studies examined decision-making in a clinical setting, and no studies reported long-term follow-up. Future research should look to identify why some interventions demonstrate low effectiveness, the conditions which enable high effectiveness, and effectiveness in environments beyond vignettes and among attending physicians.
PROSPERO registration number: CRD42022331128
Management of Alzheimer’s disease in the next ten years
Authors: Sani Immanuel
Published: March 2023

Since the inception of clinical neuroscience, scientific breakthroughs have enhanced our knowledge of how certain pathologies impair the function of the nervous system. Alzheimer’s disease (AD) is a perpetual challenge in modern clinical neuroscience due to the ageing population, which makes individuals increasingly susceptible to AD. On a global scale, AD is the most common form of dementia and the number of people living with dementia worldwide has more than doubled from 1990 to 2016, which warrants prompt development of effective interventions that may halt or delay disease progression. This narrative review recommends further investigation into the effectiveness of monoclonal antibody treatment in patients with early AD and the utilisation of several laboratory tools to understand the complex aetiology of AD. In the next ten years, it is hoped that the recommendations in this article may come to fruition and facilitate further advancements in clinical neuroscience to develop therapies that delay the onset and even reverse the clinical manifestation of AD that currently has a poor prognosis.
Applying the principles of Design Thinking to the Intensive Care Environment
Authors: Ukagwu Chijindu , Gray Seth
Published: March 2023

Patient-centered care and evidence-based medicine are mantras that form the foundation of modern healthcare practice. Yet, most of the tools for designing healthcare solutions, including randomized control trials, quality improvement initiatives, and even qualitative research, are often better adapted to providing an evidence-based foundation for practice at the expense of patient, family, and healthcare worker needs. These approaches tend to focus on improving outcomes and processes (Grys, 2022). Stakeholders — particularly patients, but also staff – are objects being scrutinized by “experts” under the scientific or medical gaze, filtering out what the “expert” deems as irrelevant (O’Callaghan, 2022). However, outcomes and processes are not sufficient if they do not prioritize human voice, dignity, and participation. Design thinking provides a complementary approach to evidence-based medicine by engaging the person in experimenting, prototyping, giving feedback, and redesigning healthcare solutions centered around the needs of humans (Razzouk & Shute, 2012). This article describes the process of design thinking as an approach to the creation of human-centered solutions and makes reference to the implementation of the design thinking process in the intensive care unit (ICU) of SickKids, an academic paediatric hospital in Ontario.
Tagraxofusp for blastic plasmacytoid dendritic cell neoplasm
Authors: Luskin Marlise R. , Lane Andrew A.
Published: March 2023

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that presents with characteristic dark purple skin papules, plaques, and tumors, but may also involve the bone marrow, blood, lymph nodes, and central nervous system. The disease, which commonly affects older men but can also present in children, is associated with a distinct immunophenotype including universal expression of CD123, the alpha chain of the interleukin 3 receptor. Recently, tagraxofusp, a CD123-targeting drug consisting of the ligand for CD123, interleukin 3, conjugated to a truncated diphtheria toxin payload was approved for treatment of BPDCN. This was the first agent specifically approved for BPDCN and the first CD123 targeted agent in oncology. Here, we review the development of tagraxofusp and the key preclinical insights and clinical data that led to approval. Tagraxofusp treatment is associated with a unique toxicity, capillary leak syndrome (CLS), which can be severe but is manageable with proper patient selection and monitoring, early recognition, and directed intervention. We outline our approach to the use of tagraxofusp and discuss open questions in treatment of BPDCN. Overall, tagraxofusp represents a unique targeted therapy and a step forward in meeting an unmet need for patients with this rare disease.
Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine
Authors: Assouline Sarit , Gasiorek Jadwiga , Bergeron Julie , Lambert Caroline , Culjkovic-Kraljacic Biljana , Cocolakis Eftihia , Zakaria Chadi , Szlachtycz David , Yee Karen , Borden Katherine L.B.
Published: March 2023

Drug resistance underpins poor outcomes in many malignancies including refractory and relapsed acute myeloid leukemia (R/R AML). Glucuronidation is a common mechanism of drug inactivation impacting many AML therapies, e.g., cytarabine, decitabine, azacytidine and venetoclax. In AML cells, the capacity for glucuronidation arises from increased production of the UDP-glucuronosyltransferase 1A (UGT1A) enzymes. UGT1A elevation was first observed in AML patients who relapsed after response to ribavirin, a drug used to target the eukaryotic translation initiation factor eIF4E, and subsequently in patients who relapsed on cytarabine. UGT1A elevation resulted from increased expression of the sonic-hedgehog transcription factor GLI1. Vismodegib inhibited GLI1, decreased UGT1A levels, reduced glucuronidation of ribavirin and cytarabine, and re-sensitized cells to these drugs. Here, we examined if UGT1A protein levels, and thus glucuronidation activity, were targetable in humans and if this corresponded to clinical response. We conducted a phase II trial using vismodegib with ribavirin, with or without decitabine, in largely heavily pre-treated patients with high-eIF4E AML. Pre-therapy molecular assessment of patients’ blasts indicated highly elevated UGT1A levels relative to healthy volunteers. Among patients with partial response, blast response or prolonged stable disease, vismodegib reduced UGT1A levels, which corresponded to effective targeting of eIF4E by ribavirin. In all, our studies are the first to demonstrate that UGT1A protein, and thus glucuronidation, are targetable in humans. These studies pave the way for the development of therapies that impair glucuronidation, one of the most common drug deactivation modalities. Clinicaltrials.gov: NCT02073838.
Relato de experiência: um projeto de extensão em boas práticas em saúde na atenção primária.
Authors: Dantas Raíssa Soares , Rodrigues Renata Viana , Picanço Nicole Mota , Madeira Neto Rodolfo Basílio , Santiago Ruan Braga , Nogueira Pedro Brito , Lima Amanda Almeida , Moura Lucas Eliel Beserra
Published: March 2023

O presente artigo tem por finalidade descrever um relato de experiência sobre um projeto de extensão em boas práticas em saúde na atenção primária em uma comunidade vinculada a uma UBS (Unidade básica de saúde) no município de Fortaleza, Ceará. O trabalho foi dividido em 3 etapas, sendo a primeira conhecer a Unidade de Atenção Primária Frei Tito e identificar os pontos de vulnerabilidade da população. Após isso, houve a definição do projeto que visava intervir no contexto alimentar dos pacientes da região e evitar doenças como diabetes e hipertensão, destacando-se ainda a presença de um CEADH (Centro especializado de diabéticos e hipertensos), o qual pesou bastante para a escolha do trabalho. No terceiro e último passo ocorreu a divisão do grupo em outros 4 subgrupos que ficaram responsáveis pela impressão de “folders” educativos, pelo “marketing” digital, pela confecção do vaso sanguíneo em “biscuit” e pela distribuição de água de coco. Vale ressaltar que o trabalho foi realizado com pessoas de todas as idades, incluindo também as gestantes. Concluiu-se que os projetos de Extensão Universitária constituem oportunidades de múltiplos benefícios, tanto para os acadêmicos e professores, quanto à comunidade participante. É de extrema importância o apoio ofertado por parte da Universidade, que também deverá ter reconhecimento diante da sociedade por causa da ajuda ofertada.
Etnojogos: os impactos de um projeto desenvolvido no contraturno de uma escola ribeirinha em Manaus – AM, Brasil
Authors: Brasil Maria do Céu de Oliveira
Published: March 2023

Esta pesquisa foi intitulada por “Etnojogos: os impactos de um projeto desenvolvido no contraturno de uma escola ribeirinha em Manaus-Amazonas-Brasil” teve como objetivo geral: analisar quais foram as contribuições do Projeto Etnojogos para a comunidade escolar da Escola Municipal São José I. Para obtenção de dados, foi utilizada a metodologia de pesquisa bibliográfica, descritiva, etnográfica e documental, com enfoque ao tipo de pesquisa qualitativa e quantitativa. Concluiu-se que as ações do Projeto Etnojogos, permitiram a valorização cultural e a construção do conhecimento. Desta forma, utilizando atividades lúdicas, o projeto estimulou busca de conhecimento intelectual e consequentemente a melhora no rendimento escolar por meio do desenvolvimento lógico e linguístico. Através do Etnojogos os alunos interagiam uns com os outros para elaborar estratégias na confecção e pintura dos artefatos, pesquisavam as possibilidades de como jogar, modo de como aperfeiçoar seus instrumentos, tornando-os mais precisos e eficientes na hora da brincadeira. Reafirmado assim que, por meio das atividades lúdicas o aprendizado torna-se mais prazeroso.
O estudo da biodiversidade animal: uma ação educativa investigativa realizada em ambientes rurais com alunos do ensino médio
Authors: Oliveira Diego Rafael Ferreira de , Santos Ednilza Maranhão dos
Published: March 2023

Objetivo: construir uma Sequência de Ensino Investigativa (SEI) que envolva diferentes estratégias pedagógicas para o desenvolvimento do protagonismo discente com o tema: biodiversidade animal. Metodologia: este estudo é categorizado como uma pesquisa de campo em área rural, e também uma observação participante. Participaram desta ação educativa vinte estudantes do terceiro ano do ensino médio da rede pública, distribuídos em quatro equipes, totalizando seis horas/aulas. Quatro etapas fizeram parte dessa vivência. ETAPA 1: problematização do tema gerador (Como se apresenta a fauna da minha localidade?) e aula campo com Levantamento Faunístico Local (LFL); ETAPA 2: descrição de pelo menos três características sinapomórficas dos grupos de vertebrados identificados no LFL; ETAPA 3: discussão teórica do conteúdo, construção de teias alimentares, categorias do meio biótico e níveis tróficos a partir do LFL; ETAPA 4: apresentação dos materiais produzidos e confronto de ideias. Resultados: As equipes identificaram 184 animais, distribuídos em 29 espécies; 06 classes, sendo 03 de vertebrados. Conceitos biológicos como riqueza e abundância foram discutidos. As equipes II e IV atingiram satisfatoriamente todas as etapas. Entretanto, apenas duas características sinapomórficas foram descritas e erro na identificação dos níveis tróficos nas equipes I e III, respectivamente. Conclusão: SEI quando bem planejada aguça a construção de novos saberes, estimula a liberdade intelectual dos estudantes, desenvolve a argumentação, bem como, a reflexão crítica, o raciocínio científico que são pressupostos basilares para o Ensino da Biologia por Investigação.
EFFICIENT TRANSFORMATION OF USE CASE MAIN SUCCESS SCENARIO STEPS INTO BUSSINESS OBJECT RELATION (BORM) DIAGRAMS FOR EFFECTIVE BUSSINESS PROCESS REQUIREMENT ANALYSIS
Authors: PODARAS ATHANASIOS , MORAVEC JOSEF , PAPIK MARTIN
Published: March 2023

The basic part of an innovative and modern approach to business process requirement analysis which is based on the simultaneous utilization of UML Use Case approach and the Business Object Relation Modelling approach is analyzed in the present paper. Precisely the transition rules by which the Use Case Main Success Scenario steps are converted into to a BORM diagram, entitled as the Use Case To BORM Transformation Algorithm (UCBTA) transition rules, are presented as a pattern based method which leads to the effective and efficient business process requirement analysis.
DRAMATIC ART AND DRAMATIC EXPRESSION THROUGH CREATIVE DRAMA METHODS IN PRESCHOOL EDUCATION
Authors: ROCHOVSKÁ IVANA , ŠVÁBOVÁ BOŽENA
Published: March 2023

The research focuses on determining the opinions of kindergarten teachers on the issue of applying dramatic expression in preschool education within five dimensions - the current state of the use of dramatic art and dramatic expression through creative drama methods within preschool education, drawing ideas for working with a work of dramatic art, an assessment of the children’s interest in working with a work of dramatic art by the kindergarten teachers, the relationship of kindergarten teachers towards dramatic art, and the opportunities for kindergarten teachers to acquire knowledge of dramatic art and creative drama within their undergraduate training or other forms of education. 366 kindergarten teachers responded to the items of the self-constructed questionnaire. It has been shown that the current state of the use of dramatic art and dramatic expression through creative drama methods in preschool education can be described as slightly above average. The opportunities for kindergarten teachers to acquire knowledge of dramatic art and creative drama in their undergraduate training or other forms of education were below average. The relationship of kindergarten teachers towards dramatic art can also be described as lower than average. The research clearly confirmed that the opportunities for acquiring knowledge from dramatic art and creative drama statistically significantly positively predict the relationship of kindergarten teachers towards dramatic art. Likewise, it was confirmed that the relationship of kindergarten teachers towards dramatic art statistically significantly positively predicts the use of works of dramatic art through creative drama methods in preschool education.
IDENTIFYING THE SIGNIFICANCE OF THE IMPACT OF THE CANVAS BUSINESS MODEL ON STARTUPS' PERFORMANCE INDICATORS
Authors: MIKLE LENKA , MIŠÚN JURAJ , MIŠÚNOVÁ HUDÁKOVÁ IVANA
Published: March 2023

Startups are unpredictable, but above all unpredictable enterprises, which can hardly be attributed a universally valid recommendation for their existence. For startups, it is very important to recall that there is no constant business model for them. The current literature provides a number of business models that could be a guide for startups, but it would make little sense to establish a universally valid model given their diversity, instability and variability. In this paper, we describe the Canvas business model, which serves as a visualization of the current state of real functioning Slovak startups, and we further gain valuable insights and valuable knowledge based on this model. The main objective is to identify the significance of the impact of the Canvas business model on the performance indicators of startups. The achieved results and the metamorphosis of real functioning startups contribute to the expansion of knowledge of this relatively new and promising entrepreneurial phenomenon. The startup environment is many times presented by the most successful representatives and the less successful ones quietly sink into oblivion. Representatives of unsuccessful startups do not like to provide data and information about their business.
Frugal Approach for The Design of a Rehabilitation Physical System
Authors: Solarte Bolaños Ruben Dario , Valdiero Antonio Carlos , Espindola Ferreira Joao Carlos , Vigolo Vinícius , Guimarães de Souza Isaac Varela Brito , Pitta De Araujo Tárik El Hayek Rocha
Published: March 2023

In the rehabilitation process, robotic structures can support the different medical-surgical actions. These recovery process activities often involve repetitive movements that must be performed several times at various amplitudes. Robotic structures for rehabilitation can be driven by three types of active drives, namely electric, pneumatic and hydraulic actuators. Pneumatic systems have become increasingly present in various market segments and are widely used in the industry, mainly due to their ease of maintenance, low cost, safety and applicability in various processes. Currently, the concept of Frugal Innovation is being discussed, which emerges as a way to produce effective and affordable products using fewer resources to reach less-served customers. Frugal Innovation is centered on saving resources, is characterized by simplicity and clarity and aims to reach the low-income market. This article proposes the application of Frugal development methods in the design of a lower limb rehabilitation system. With the application of frugal concepts, pneumatic actuators were chosen. The choice of the pneumatic cylinder is presented from the required pneumatic force. The application of the Frugal Innovation approach in the design of this type of products demonstrates the relevance of applying these methods in efforts to mitigate or reduce the growth of the technological gap between underdeveloped and developed countries.
Análise institucional de um serviço de emergência psiquiátrica: o diário de pesquisa de uma psicóloga residente
Authors: Cenerino Isadora , Ferrazza Daniele
Published: March 2023

O cenário de cuidado para com os sujeitos em intenso sofrimento psíquico, em 1970, consistia na internação em instituições manicomiais marcadas pela violação de Direitos Humanos. Com o advento da Reforma Psiquiátrica Brasileira em 1990, novos dispositivos de cuidado territoriais em saúde mental substitutivos à internação em hospitais psiquiátricos foram criados, entre eles os serviços de Emergências Psiquiátricas (EP). Assim, compreende-se que as Emergências Psiquiátricas se apresentam na Rede de Atenção Psicossocial (RAPS) como um serviço de atendimento à crise quando os demais dispositivos territoriais da rede já estão esgotados para o manejo desse indivíduo. Nessa perspectiva, o presente trabalho teve o objetivo de analisar o funcionamento institucional de uma Emergência Psiquiátrica de um município do interior do Estado do Paraná, com atenção especial à atuação dos profissionais da equipe de saúde em um contexto pandêmico. Para tanto, realizou-se uma pesquisa-intervenção, fundamentada nas ferramentas conceituais da Análise Institucional, em que foram analisados diários de pesquisa produzidos pela pesquisadora residente do Programa de Residência Multiprofissional em Urgência e Emergência. Como resultados verificou-se a dificuldade de superação do modelo manicomial pelo serviço estudado, problemáticas relacionadas ao trabalho em equipe e a complexidade na articulação com outros dispositivos da RAPS. Espera-se que movimentos instituintes da luta antimanicomial continuem produzindo questionamentos, reflexões e capacitações para novos modos de cuidado mais humanizados, integrais, efetivos e atentos às especificidades de atenção aos sujeitos em intenso sofrimento psíquico em Emergências Psiquiátricas.
Recent advancement in finite element analysis of spinal interbody cages: A review
Authors: Wang Ruofan , Wu Zenghui
Published: March 2023

Finite element analysis (FEA) is a widely used tool in a variety of industries and research endeavors. With its application to spine biomechanics, FEA has contributed to a better understanding of the spine, its components, and its behavior in physiological and pathological conditions, as well as assisting in the design and application of spinal instrumentation, particularly spinal interbody cages (ICs). IC is a highly effective instrumentation for achieving spinal fusion that has been used to treat a variety of spinal disorders, including degenerative disc disease, trauma, tumor reconstruction, and scoliosis. The application of FEA lets new designs be thoroughly “tested” before a cage is even manufactured, allowing bio-mechanical responses and spinal fusion processes that cannot easily be experimented upon in vivo to be examined and “diagnosis” to be performed, which is an important addition to clinical and in vitro experimental studies. This paper reviews the recent progress of FEA in spinal ICs over the last six years. It demonstrates how modeling can aid in evaluating the biomechanical response of cage materials, cage design, and fixation devices, understanding bone formation mechanisms, comparing the benefits of various fusion techniques, and investigating the impact of pathological structures. It also summarizes the various limitations brought about by modeling simplification and looks forward to the significant advancement of spine FEA research as computing efficiency and software capabilities increase. In conclusion, in such a fast-paced field, the FEA is critical for spinal IC studies. It helps in quantitatively and visually demonstrating the cage characteristics after implanting, lowering surgeons’ learning costs for new cage products, and probably assisting them in determining the best IC for patients.
Phosphoserine-loaded chitosan membranes promote bone regeneration by activating endogenous stem cells
Authors: Ke Yue , Ye Yu , Wu Jintao , Ma Yanxia , Fang Yuxin , Jiang Fei , Yu Jinhua
Published: March 2023

Bone defects that result from trauma, infection, surgery, or congenital malformation can severely affect the quality of life. To address this clinical problem, a phosphoserine-loaded chitosan membrane that consists of chitosan membranes serving as the scaffold support to accommodate endogenous stem cells and phosphoserine is synthesized. The introduction of phosphoserine greatly improves the osteogenic effect of the chitosan membranes via mutual crosslinking using a crosslinker (EDC, 1-ethyl-3-(3-dimethyl aminopropyl)-carbodiimide). The morphology of PS-CS membranes was shown by scanning electron microscopy (SEM) to have an interconnected porous structure. The incorporation of phosphoserine into chitosan membranes was confirmed by energy dispersive spectrum (EDS), Fourier Transforms Infrared (FTIR), and X-ray diffraction (XRD) spectrum. The CCK8 assay and Live/Dead staining, Hemolysis analysis, and cell adhesion assay demonstrated that PS-CS membranes had good biocompatibility. The osteogenesis-related gene expression of BMSCs was higher in PS-CS membranes than in CS membranes, which was verified by alkaline phosphatase (ALP) activity, immunofluorescence staining, and real-time quantitative PCR (RT-qPCR). Furthermore, micro-CT and histological analysis of rat cranial bone defect demonstrated that PS-CS membranes dramatically stimulated bone regeneration in vivo. Moreover, H&E staining of the main organs (heart, liver, spleen, lung, or kidney) showed no obvious histological abnormalities, revealing that PS-CS membranes were no additional systemic toxicity in vivo. Collectively, PS-CS membranes may be a promising candidate for bone tissue engineering.