bluuebunny/crossref_metadata_2025 huggingface dataset:
Organic agriculture in a low-emission world: exploring combined measures to deliver a sustainable food system in Sweden
Authors: Basnet Shyam , Wood Amanda , Röös Elin , Jansson Torbjörn , Fetzer Ingo , Gordon Line
Published: January 2023

In the EU, including Sweden, organic farming is seen as a promising pathway for sustainable production, protecting human health and animal welfare, and conserving the environment. Despite positive developments in recent decades, expanding organic farming to the Swedish national target of 30% of farmland under organic production remains challenging. In this study, we developed two scenarios to evaluate the role of organic farming in the broader context of Swedish food systems: (i) baseline trend scenario (Base), and (ii) sustainable food system scenario (Sust). Base describes a future where organic farming is implemented alongside the current consumption, production and waste patterns, while Sust describes a future where organic farming is implemented alongside a range of sustainable food system initiatives. These scenarios are coupled with several variants of organic area: (i) current 20% organic area, (ii) the national target of 30% organic area by 2030, and (iii) 50% organic area by 2050 for Sust. We applied the ‘FABLE (Food, Agriculture, Biodiversity, Land-use and Energy) Calculator’ to assess the evolution of the Swedish food system from 2000 to 2050 and evaluate land use, emissions and self-sufficiency impacts under these scenarios. Our findings show that expanding organic farming in the Base scenarios increases the use of cropland and agricultural emissions by 2050 compared to the 2010 reference year. However, cropland use and emissions are reduced in the Sust scenario, due to dietary changes, reduction of food waste and improved agricultural productivity. This implies that there is room for organic farming and the benefits it provides, e.g. the use of fewer inputs and improved animal welfare in a sustainable food system. However, changing towards organic agriculture is only of advantage when combined with transformative strategies to promote environmental sustainability across multiple sections, such as changed consumption, better production and food waste practices.
Molecular and therapeutic effect of CRISPR in treating cancer
Authors: Rodrigo Sawani , Senasinghe Kaveesha , Quazi Sameer
Published: January 2023

Cancer has become one of the common causes of mortality around the globe due to mutations in the genome which allows rapid growth of cells uncontrollably without repairing DNA errors. Cancers could arise due alterations in DNA repair mechanisms (errors in mismatch repair genes), activation of oncogenes and inactivation of tumor suppressor genes. Each cancer type is different and each individual has a unique genetic change which leads them to cancer. Studying genetic and epigenetic alterations in the genome leads to understanding the underlying features. CAR T therapy over other immunotherapies such as monoclonal antibodies, immune checkpoint inhibitors, cancer vaccines and adoptive cell therapies has been widely used to treat cancer in recent days and gene editing has now become one of the promising treatments for many genetic diseases. This tool allows scientists to change the genome by adding, removing or altering genetic material of an organism. Due to advance in genetics and novel molecular techniques such as CRISPR, TALEN these genes can be edited in such a way that their original function could be replaced which in turn improved the treatment possibilities and can be used against malignancies and even cure cancer in future along with CAR T cell therapy due to the specific recognition and attacking of tumor.
Assessment of Cadmium Concentrations in Foodstuffs and Dietary Exposure Risk Across China: A Metadata Analysis
Authors: Qing Ying , Li Yongzhen , Cai Xinyi , He Wenting , Liu Shishi , Ji Yunhe , Jiang Meng , Yang Linjing , Wang Jutao , Ping Siyuan , Chen Yu , Luo Yingyi , Li Yanfei
Published: January 2023

Cadmium (Cd) is a persistent and toxic heavy metal widely present in the environment and can cause damage to a variety of human organs and systems. Based on published studies from 2000 to 2021, this study established a comprehensive database of Cd concentrations in Chinese foods, and described the spatial and temporal trends of Cd concentrations in foods across China. The average Cd concentration in total foodstuff was 0.078 mg/kg, with edible fungi and algae having the highest concentrations, followed by aquatic foods, nuts, cereals, beans, vegetables, meats, eggs, milk, and fruits. The average dietary Cd exposure of Chinese residents was 34.3 μg/day (varying from 22.6 to 54.5 μg/day across regions), with the highest exposures in South China. Cereals (46.2%), vegetables (19.2%), and aquatic food (18.4%) contributed the most to the dietary Cd exposure of Chinese residents. According to Monte Carlo simulations of the risk assessment of dietary exposure to Cd, approximately, 15.4% of the Chinese population exceeded the Joint FAO/WHO Expert Committee on Food Additives health-based guidance value. The hazard quotient and excess lifetime cancer risk indices of dietary Cd exposure indicated that the Chinese residents would not be at significant non-cancer and carcinogenic risk. In summary, this study obtained comprehensive and reliable results on Cd concentrations in Chinese food and dietary Cd exposure risk of Chinese residents, which can provide a data base for the development of dietary Cd exposure limits in China.
Clinical spectrum and currently available treatment of type I interferonopathy Aicardi–Goutières syndrome
Authors: Dell’Isola Giovanni Battista , Dini Gianluca , Culpepper Kaleb Logan , Portwood Katherin Elizabeth , Ferrara Pietro , Di Cara Giuseppe , Verrotti Alberto , Lodolo Mauro
Published: January 2023

Background

Aicardi–Goutières syndrome (AGS) is a genetically determined disorder with a variable phenotype. Since the original description of AGS, advances in gene sequencing techniques have resulted in a significant broadening of the phenotypic spectrum associated with AGS genes, and new clinical pictures have emerged beyond the classic presentation. The aim of this review is to provide a comprehensive analysis of the clinical spectrum of AGS and report currently available treatments and new immunosuppressive strategies.

Data sources

Literature reviews and original research articles were collected from databases, including PubMed and ClinicalTrials.gov. Relevant articles about AGS were included.

Results

The involvement of the nervous system certainly represents the major cause of mortality and morbidity in AGS patients. However, other clinical manifestations, such as chilblains, hepatosplenomegaly, and hematological disturbances, may lead to the diagnosis and considerably impact the prognosis and overall quality of life of these patients. Therapeutic approaches of AGS are limited to interventions aimed at specific symptoms and the management of multiple comorbidities. However, advances in understanding the pathogenesis of AGS could open new and more effective therapies.

Conclusions

The over-activation of innate immunity due to upregulated interferon production plays a critical role in AGS, leading to multi-organ damage with the main involvement of the central nervous system. To date, there is no specific and effective treatment for AGS. New drugs specifically targeting the interferon pathway may bring new hope to AGS patients.
Recovery of High Valuable Bioactive Molecules from Vaccinium myrtillus L. Bioresidues
Authors: Plasencia Paula , Heleno Sandrina A. , Finimundy Tiane , Carocho Márcio , Calhelha Ricardo C. , Añibarro-Ortega Mikel , Alves Maria José , Oludemi Taofiq , Quidiongo Nuno , Barreiro Filomena , García Pablo A. , Ferreira Isabel C. F R. , Barros Lillian
Published: January 2023

Purpose

The interest in using bioresidues produced by the agri-food industry is increasingly intrinsic to the world economy. As such, researchers started to look for new ways to enhance its use, developing innovations to transform these residues into high-value raw materials with industrial application, promoting the circular economy concept.

Methods

Therefore, pruning residues from the production of Vaccinium myrtillus L. could be an interesting exploitation field, given its position as a superfood due to its well-known antioxidant properties. The antioxidant, antibacterial, anti-inflammatory, anti-tyrosinase, and cytotoxicity potentials of aqueous and hydroethanolic extracts of V. myrtillus aerial parts were evaluated.

Results

From the obtained results, ultrasound-assisted and maceration extracts were found to be as effective as, if not more effective than, conventional antibiotics against methicillin-resistant Staphylococcus aureus. Aside from antibacterial activity, the extracts also showed antioxidant and anti-tyrosinase effects, which were found to be favourably related to the level of caffeoylquinic acid derivatives.

Conclusion

The obtained results highlight the bioactive potential and the importance of exploiting this bio residue as a novel candidate for industrial application, taking advantage of their biological properties.

Graphical Abstract
Critical metrics for quadratic curvature functionals on some solvmanifolds
Authors: Calvaruso Giovanni , Zaeim Amirhesam
Published: January 2023

We prove the existence of four-dimensional compact manifolds admitting some non-Einstein Lorentzian metrics, which are critical points for all quadratic curvature functionals. For this purpose, we consider left-invariant semi-direct extensions $$G_{\mathcal S}=H \rtimes \exp ({\mathbb {R}}S)$$

G
S

=
H
⋊
exp

(
R
S
)

of the Heisenberg Lie group H, for any $$\mathcal S \in {\mathfrak {s}}{\mathfrak {p}}(1,\mathbb R)$$

S
∈
s
p
(
1
,
R
)

, equipped with a family $$g_a$$

g
a

of left-invariant metrics. After showing the existence of lattices in all these four-dimensional solvable Lie groups, we completely determine when $$g_a$$

g
a

is a critical point for some quadratic curvature functionals. In particular, some four-dimensional solvmanifolds raising from these solvable Lie groups admit non-Einstein Lorentzian metrics, which are critical for all quadratic curvature functionals.
Two Kinds of Process or Two Kinds of Processing? Disambiguating Dual-Process Theories
Authors: Augusto Rafael
Published: January 2023

Dual-Process Theories (D-PTs) claim there are two qualitatively different types of processes in the human brain-mind. Despite forming the basis for several areas of cognitive science, they are still shrouded in ambiguity: critics erroneously attack D-PTs as a whole (e.g., Evans and Stanovich Perspectives on Psychological Science, 8(3), 2013), the qualitative/quantitative distinction is not clear enough (De Neys Perspectives on Psychological Science 16 (6): 1412–1427, 2021; Dewey 2022) and, given this criterion, deciding between qualitative or quantitative differences may even be scientifically irrelevant (De Neys 2021). As a way of disambiguating the discussion and clarifying what exactly means to claim the existence of a second type of process, I define two possible categories of D-PT: The substantial and the instrumental. In the substantial case, Type 2 processes are subpersonal level ones. In the instrumental case, Type 2 processing is a personal level phenomenon that does not necessarily imply subpersonal level Type 2 processes. Discussing the different implications of each of the categories, I use as a main example to illustrate the ambiguity – and the exercise of disambiguation – the model proposed by Evans and Stanovich (2013), making clear its substantial character, and contrast it with Frankish’ (2009) – a clear case of instrumental D-PT. Finally, I discuss the contributions this distinction can make. By making the discussion clearer, it can provide a relatively unanimous framework for dual- and single-process theorists (the instrumental version) and clearer desiderata for those wishing to defend the substantive one.
Integrated Public Transportation System with Shared Autonomous Vehicles and Fixed-Route Transits: Dynamic Traffic Assignment-Based Model with Multi-Objective Optimization
Authors: Maruyama Ryota , Seo Toru
Published: January 2023

The shared autonomous vehicle (SAV) system is considered as an efficient transportation mode in the future. In the literature, optimization of SAV systems has been extensively studied. However, SAV systems could bring greater social benefits if we could use them with existing public transportation systems, such as bus rapid transit (BRT), in an integrated manner. This study proposes a model of SAV-BRT system, an integrated system that takes advantage of the flexibility of SAVs and the mass transport capability of BRT. The proposed model is based on a dynamic traffic assignment model so that it captures important features of SAV-BRT system, such as endogenous traffic congestion, detour and waiting of SAVs, BRT’s dynamic scheduling. The model is formulated as a multi-objective optimization problem so that trade-off relations regarding the system’s performance can be explicitly analyzed. The behavior of the model is investigated by conducting numerical experiments based on actual travel data obtained from an urban area in Japan. As a result, we confirmed that the model behaves reasonably, and several insights on SAV-BRT systems have been obtained.
Numerical simulation of wake interactions on a tandem wing configuration in high-speed stall conditions
Authors: Kleinert Johannes , Stober Jonathan , Lutz Thorsten
Published: January 2023

In this work, the interaction of the separated wake of the front wing with the rear wing of a tandem configuration is investigated for high-speed stall conditions by means of hybrid RANS/LES simulations, using the zonal AZDES method. After a characterization of the transonic buffet on the front wing, the development of the separated turbulent wake behind the wing is investigated. The interaction of the separated wake with the rear wing is then analyzed in detail. The results reveal that there is a strong variation in the wake characteristics over the buffet cycle, caused by the varying amount of separation on the front wing. During the upstream movement of the shock, the flow is largely separated, resulting in a thick wake with strong, high-frequent fluctuations that can be attributed to large turbulent vortices. On the contrary, when the shock travels downstream, there is only a small amount of separation present, resulting in a thin wake with comparatively low fluctuations that are caused by corresponding smaller turbulent vortices. The impact of the wake of the front wing causes a strong variation in the rear wing loading. An oscillation with a comparatively low frequency can be distinguished from high-frequent fluctuations. The low-frequent oscillation is caused by the variation in the downwash behind the front wing as its lift changes during the buffet cycle. The high-frequent fluctuations are due to the impingement of the turbulent structures onto the rear wing. Because both size and frequency of those vortices vary significantly within the buffet cycle, the amplitude and frequency of the lift and surface pressure fluctuations also change accordingly.
Nigella sativa tea mitigates type-2 diabetes and edema: a case report
Authors: Choo Thin-Meiw
Published: January 2023

Diabetes is a major deadly disease. In 2019 alone, it caused an estimated 1.5 million deaths world-wide. Cases of diabetes are rising rapidly in low- and middle-income countries. Natural remedies that can lower the glucose level would be very useful, particularly to people living in low- and middle-income countries. A 2-year case study was carried out, therefore, to determine if Nigella sativa tea can lower the glucose level in a 72-year-old man with type-2 diabetes, stage 3–4 chronic kidney disease, and congestive heart failure. Changes in body weight, lipids, estimated glomerular filtration rate (eGFR), and urinary albumin-to-creatinine ratio (UACR) were also studied. N. sativa tea was prepared with N. sativa, barley, and wheat seeds. The 72-year-old drank approximately 50 ml of N. sativa tea daily, in the morning. Results showed that after drinking N. sativa tea daily, hypoglycemia started to occur and occurred more frequently as time went by and that the glycated hemoglobin, HbA1c, was decreasing. Subsequently, the dosages of insulin glargine and insulin aspart were reduced by 33% and 50%, respectively. Results also showed that weight loss led to the 72-year-old cutting back his intake of the diuretic furosemide by at least 50%. His triglycerides level was also lower and there were no changes in his total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels. His eGFR was stable but his UACR was worsening. N. sativa tea is easy to prepare, costs very little, and could be a natural remedy for mitigating diabetes and edema. Many more studies on N. sativa are warranted.
An explainable deepfake detection framework on a novel unconstrained dataset
Authors: Mathews Sherin , Trivedi Shivangee , House Amanda , Povolny Steve , Fralick Celeste
Published: January 2023

In this work, we created a new large-scale unconstrained high-quality Deepfake Image (DFIM-HQ) dataset containing 140K images. Compared to existing datasets, this dataset includes a variety of diverse scenarios, pose variations, high-quality degradations, and illumination variations, making it a particularly challenging dataset. Since computer vision models learn to perform a task by capturing relevant statistics from training data, they tend to learn spurious age, gender, and race correlations leading to learning biases. To account for AI bias in our proposed DFIM-HQ dataset, we design a simple yet effective image recognition benchmark for studying bias mitigation. Our detection system makes use of an Inception-based network to extract frame-level features and automatically detect manipulated content. We also propose an explainability framework that provides a better understanding of the model’s prediction. Such informed decisions provide insights that can be used to improve the model and, thereby, helps to add trust to the model. Our evaluation illustrates that our frameworks can achieve competitive results in detecting deepfake images using deep learning architectures.
Incomplete linguistic q-rung orthopair fuzzy preference relations and their application to multi-criteria decision making
Authors: Li Tao , Zhang Liyuan , Zhang Zhenglong
Published: January 2023

With the development of social and economic research, the judgements that people deal with are full of fuzziness and vagueness. It is convenient to use the linguistic q-rung orthopair fuzzy numbers to offer the qualitative uncertain information. Consequently, in this paper, we mainly study linguistic q-rung orthopair fuzzy preference relations (Lq-ROFPRs) and apply them to a multi-criteria decision-making (MCDM) problem. The multiplicative consistency of Lq-ROFPRs is first introduced, then a consistency-based model is established to derive the normalized linguistic q-rung orthopair fuzzy priority weight vector. The concept of acceptably multiplicative consistency is further defined, and an optimization model is formulated to repair the unacceptably multiplicative consistent Lq-ROFPR. To cope with the incomplete Lq-ROFPR, another programming model is built to ascertain the missing values. The weights of criteria are determined by constructing a possibility degree matrix. Subsequently, an MCDM problem with incomplete Lq-ROFPRs is considered and a step-by-step algorithm is put forward. Finally, the proposed method is applied to three examples, and the advantages of this new approach are also demonstrated.
Effect of Soil Mixtures Based on a Gneiss-Derived Soil and Two Forest Floor Types on Growth and Nutritional Status of Castanea sativa Mill. Seedlings
Authors: Papaioannou Evgenia , Gasparatos Dionisios , Stefanou Stefanos , Chatzistathis Theocharis , Karamanoli Katerina , Matziris Evangelos
Published: January 2023

Aiming at the production of robust chestnut plants suitable for the establishment of plantations or for their use in afforestation of forest ecosystems, we studied the effect of soil mixtures on growth, physiological characteristics, and nutritional status of chestnut seedlings. In a complete randomized-block design pot experiment, the soil used was derived from gneiss weathering (GN) and the treatments included GN and GN with fertilization (GN-FER) as well as mixtures of GN with forest floor (FF) from chestnuts (GN-CFF) and from evergreen broad-leaved trees (GN-EFF). Both types of forest floor and fertilization had similar positive effect on seedlings growth and photosynthetic parameters. The most significant effects on soil nutrients were found in GN-CFF and GN-EFF treatments, except for extractable phosphorus (P) and exchangeable potassium (K), whose highest concentrations were observed in GN-FER. Leaf analysis showed that the concentrations of almost all nutrients in all treatments were within the adequacy limits, with the exception of nitrogen (N) in GN, copper (Cu) in GN-EFF, and K in all treatments. Both types of forest floor satisfied the nutritional needs of chestnut seedlings to a large extent and their incorporation in this type of soil combined with limited addition mainly of K and to a lesser degree of P could enhance adequacy of these nutrients in soil and plants. Thus, forest floor application may be an appropriate alternative to integrated nutrient management for robust chestnut seedlings production with significant forestry and environmental impacts.
Optimizing biochar addition for vermicomposting: a comprehensive evaluation of earthworms’ activity, N2O emissions and compost quality
Authors: Wu Yupeng , Li Qinfen , Zheng Yong , Xiong Xingjun , Chen Yunfeng , Shaaban Muhammad , Hu Ronggui
Published: January 2023

Biochar addition has been widely used in the field to mitigate soil nitrous oxide (N2O) emissions, and can be considered as a potential method to reduce N2O emissions during vermicomposting. However, excessive biochar addition may inhibit earthworms’ activity. Thus, it is crucial to clarify the optimum addition volumes of biochar during vermicomposting. This study evaluated the impact of addition of various amounts of biochar (0, 5, 10, 15, 20 and 25% of total amount of feedstock) on earthworms’ (Eiseniafetida) activity, N2O emission and compost quality during vermicomposting. Compared with the treatment without biochar added, 5% of biochar application significantly increased earthworm total biomass (from 177.5 to 202.2 g pot−1), and cumulative burrowing activity (from 47.0% to 52.2% pixel per terrarium). The increased earthworms activity stimulated the vermicomposting process and led to the best quality of compost, which showed the highest total nutrient content (5.38%) and a significantly higher germination percentage of seeds (88%). Although N2O emissions were slightly increased by 5% biochar addition, a non-significant difference was found between the treatment with 5% biochar and the treatment without biochar added. On the contrary, 20% and 25% biochar addition not only lowered N2O emissions, but also significantly decreased the quality of compost. The results suggest that 5% biochar application is an appropriate amount to improve the quality of compost without significant N2O emissions.

Graphical Abstract
Impact of Sub-patent Malaria During Pregnancy on Birth-Weight in Odisha, India: Time-to-Event Analysis of Prospective Longitudinal Follow-Up of a Survey
Authors: Bal Madhusmita , Ghosal Jyoti , Das Arundhuti , Sandeepta Sonali , Pati Sanghmitra , Dutta Ambarish , Ranjit Manoranjan
Published: January 2023

Objective

The current study aimed to estimate prevalence of malaria infection, especially sub-patent infection, in pregnant women residing in high malaria-endemic, hard-to-reach pockets of the Indian state of Odisha; and also measure its impact on birth-weight of their new-borns.

Method

A time-to-event analysis of prospective longitudinal follow-up study nested within a cross-sectional survey of people residing in high malaria-endemic six districts of Odisha was conducted during July–November 2019. Malaria status in pregnant mothers was categorized as malaria free; sub-patent, and patent. Hazards Ratio (HR) of low birth-weight (LBW; birth-weight < 2500 gms) was estimated in these three categories (n = 308) adjusted for residence (block), gravida, caste, age and gestational age at testing.

Results

50.3% pregnant women had sub-patent malaria infection, 3.9% had patent infection. In fully adjusted model, hazards ratio of LBW was 3.76 (95% CI 1.12, 12.64, p = 0.032) in pregnant women with patent infection and 1.82 (95% CI 0.87, 3.81, p = 0.109) in women with sub-patent infection when compared to no malaria group.

Conclusion

The study showed that half of the pregnant women in high-endemic pockets had sub-patent infection which posed deleterious influence on birth-weight of their new-borns. The study thereby flags the prevalence of sub-patent infection as a public health concern, because sub-patent infection in pregnant mothers may persist as a “silent” reservoir, with the potential to derail the malaria control program, especially when the country plans malaria elimination by 2030.
Old Age in Early Medieval England
Authors: Porck Thijs
Published: January 2023

The first full-length study of the notion and concept of old age in early medieval England.
Piano-Playing Revisited
Authors: Breitman David
Published: January 2023

A guide, linked to an online suite of video examples, to how historical instruments influenced the composers of keyboard music, and a way to look at their scores with fresh eyes and ears.
Social Doubt
Authors: ROBERTS TOM , OSLER LUCY
Published: January 2023

We introduce two concepts—social certainty and social doubt—that help to articulate a variety of experiences of the social world, such as shyness, self-consciousness, culture shock, and anxiety. Following Carel's (2013) analysis of bodily doubt, which explores how a person's tacit confidence in the workings of their body can be disrupted and undermined in illness, we consider how an individual's faith in themselves as a social agent, too, can be compromised or lost, thus altering their experience of what is afforded by the social environment. We highlight how a loss of bodily or social certainty can be shaped and sustained by the environments in which one finds oneself. As such, we show how certain individuals might be more vulnerable to experiences of bodily and social doubt than others.
Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system
Authors: Prochaska Erica C. , Xiao Shaoming , Tamma Pranita D. , Sick-Samuels Anna , Schumacher Christina , Gadala Avinash , Carroll Karen C. , Milstone Aaron M.
Published: January 2023

The epidemiology of community-onset Staphylococcus aureus infections is evolving. We performed a multihospital, retrospective study of pediatric community-onset S. aureus susceptibilities between 2015 and 2020. Oxacillin and clindamycin susceptibility remained lower at 67% and 75%, respectively. Tetracycline and trimethoprim-sulfamethoxazole susceptibility remained high at >90%. Oxacillin susceptibility was highest in invasive infections.
Association of healthcare worker behaviors with coronavirus disease 2019 (COVID-19) risk during four pandemic periods and characteristics associated with high-risk behaviors
Authors: Egbert Emily R. , Xiao Shaoming , Prochaska Erica , Ali S. Omar , Colantuoni Elizabeth , Gadala Avi , Koontz Danielle , Zhong Diana , Schumacher Christina M. , Sick-Samuels Anna C. , Debes Amanda K. , Milstone Aaron M.
Published: January 2023

In a large healthcare worker cohort, we quantified the association between behaviors and risk of coronavirus disease 2019 (COVID-19) during different pandemic phases, adjusting for prior infection and vaccination. Individual characteristics, including personal concerns, were associated with these behaviors. Public health messaging should target high-risk populations and behaviors as the pandemic evolves.
2.1 m, high-energy dissipative soliton resonance from a holmium-doped fiber laser system
Authors: Zhao Desheng , Zhang Bin , Zhu Xiran , Liu Shuailin , Jiang Li , Dou Zhiyuan , Yang Linyong , Hou Jing
Published: January 2023

We propose a 2.1 μm high-energy dissipative soliton resonant (DSR) fiber laser system based on a mode-locked seed laser and dual-stage amplifiers. In the seed laser, the nonlinear amplifying loop mirror technique is employed to realize mode-locking. The utilization of an in-band pump scheme and long gain fiber enables effectively exciting 2.1 μm pulses. A section of ultra-high numerical aperture fiber (UHNAF) with normal dispersion and high nonlinearity and an output coupler with a large coupling ratio are used to achieve a high-energy DSR system. By optimizing the UHNAF length to 55 m, a 2103.7 nm, 88.1 nJ DSR laser with a 3-dB spectral bandwidth of 0.48 nm and a pulse width of 17.1 ns is obtained under a proper intracavity polarization state and pump power. The output power and conversion efficiency are 0.233 W and 4.57%, respectively, both an order of magnitude higher than those of previously reported holmium-doped DSR seed lasers. Thanks to the high output power and nanosecond pulse width of the seed laser, the average power of the DSR laser is linearly scaled up to 50.4 W via a dual-stage master oscillator power amplifier system. The 3-dB spectral bandwidth broadens slightly to 0.52 nm, and no distortion occurs in the amplified pulse waveform. The corresponding pulse energy reaches 19.1 μJ, which is the highest pulse energy in a holmium-doped mode-locked fiber laser system to the best of our knowledge. Such a 2.1 μm, high-energy DSR laser with relatively wide pulse width has prospective applications in mid-infrared nonlinear frequency conversion.
Supervisor knowledge sharing and creative behavior: the roles of employees' self-efficacy and work–family conflict
Authors: Yoon Soohyun , Kim Seckyoung Loretta , Yun Seokhwa
Published: January 2023

Applying conservation of resources theory, we propose a theoretical model that explains how and when supervisor knowledge sharing affects creative behavior. Specifically, this study examines employee self-efficacy as the core intermediary mechanism and work–family conflict as the boundary condition of the indirect effect of supervisor knowledge sharing on creative behavior via self-efficacy. Drawn from a sample of 147 dyads comprising full-time employees and their immediate supervisors, the results of this study showed support for our moderated mediation model. The findings indicated that supervisor knowledge sharing had a significant effect on creative behavior and this influence is mediated by self-efficacy. Furthermore, our study revealed that work–family conflict attenuated the positive supervisor knowledge sharing's effect on creative behavior via self-efficacy. Implications of our findings for theory and practice are discussed.
Goryeocrinus pentagrammos n. gen. n. sp. (Rhodocrinitidae; Diplobathrida), the first record of camerate crinoid from the Middle Ordovician (Darriwilian) of South Korea (East Gondwana)
Authors: Park Hyeonmin , Lee Dong-Chan
Published: January 2023

Goryeocrinus pentagrammos n. gen. n. sp. from the Jigunsan Formation of South Korea is described and is the first diplobathrid recorded from Middle Ordovician (middle Darriwilian) strata of East Gondwana. Phylogenetic analyses suggest that G. pentagrammos n. gen. n. sp. is a member of the paraphyletic Rhodocrinitidae of the Diplobathrida and most closely related to Paradiabolocrinus from the Late Ordovician (Sandbian) of Laurentia. Goryeocrinus pentagrammos n. gen. n. sp. is characterized by having a pentameral, flat bowl-shaped calyx, a conspicuous pentagrammatic ridge formed by bifurcated median ray ridge and pentagonal basal ridge, at least two interradials in the first row of regular interrays, an anitaxial ridge originating from the CD interray but close to the C ray radial, and lacking intrabrachials and interradials between secundibrachials. The occurrence of G. pentagrammos n. gen. n. sp. from South Korea (East Gondwana) drastically expands the Ordovician paleogeographic range of camerates, which otherwise have been recorded from Laurentia, West Gondwana, Avalonia, and Baltica.

UUID: http://zoobank.org/a5f8fc12-25a5-4e7c-92e8-bf3ea07c3ba3
Multimode theory of electron hole transverse instability
Authors: Chen Xiang , Hutchinson I.H.
Published: January 2023

We present Vlasov–Poisson three-dimensional linear stability analysis of an initially planar electron hole structure, solving for the distribution function by integration along unperturbed orbits. The non-sinusoidal potential perturbation shape (parallel to$B$) is expanded in eigenfunctions of the adiabatic Poisson operator, generalizing the prior assumption of a rigid shift of the equilibrium. We show that the shiftmode is then modified by a second discrete mode plus an integral over a continuum of wave-like modes. A rigorous treatment shows that the continuum can be approximated effectively by a single mode that satisfies the external wave dispersion relation, thus making the perturbation a weighted sum of three modes. We find numerically the solution for the complex instability frequency, and the corresponding three mode amplitudes determining the perturbation eigenmode. This multimode analysis refines the accuracy of the prior single-mode results, giving slightly higher growth rates at most parameters, as expected from the extra mode shape freedom. Oscillating modes near stability boundaries have larger mode distortions which help explain particle-in-cell simulations that observe instability up to${\sim }20$ % beyond the prior shiftmode thresholds, and narrowing of the perturbation. At high magnetic field, the multimode analysis predicts a reduction of the already small growth rate.
‘A ruinous infatuation’: Nutmeg cultivation in early Penang
Authors: Skott Christina
Published: January 2023

Between 1786 and the 1860s, Penang Island was transformed from a lush tropical island into a British colony covered in ordered plantations. As a consequence of Britain's temporary possession of the fabled Spice Islands, nutmeg emerged as the most important crop, but after decades of experimentation and uncertainty, its cultivation ultimately failed. Although the struggle for nutmeg to become commercially viable was heavily dependent on global price fluctuations and official support, this article focuses on local factors such as shortages of labour, the specific skills of the island's various ethnic groups and reliance on indigenous agricultural techniques. The story of nutmeg cultivation in Penang can then be situated within a wider historiography concerned with the transmission of botanical knowledge and plant transfer, as well as the ecological impact of colonial agriculture.
The Theory-Practice Gap in the Evaluation of Agent-Based Social Simulations
Authors: Anzola David
Published: January 2023

Argument

Agent-based social simulations have historically been evaluated using two criteria: verification and validation. This article questions the adequacy of this dual evaluation scheme. It claims that the scheme does not conform to everyday practices of evaluation, and has, over time, fostered a theory-practice gap in the assessment of social simulations. This gap originates because the dual evaluation scheme, inherited from computer science and software engineering, on one hand, overemphasizes the technical and formal aspects of the implementation process and, on the other hand, misrepresents the connection between the conceptual and the computational model. The mismatch between evaluation theory and practice, it is suggested, might be overcome if practitioners of agent-based social simulation adopt a single criterion evaluation scheme in which: i) the technical/formal issues of the implementation process are tackled as a matter of debugging or instrument calibration, and ii) the epistemological issues surrounding the connection between conceptual and computational models are addressed as a matter of validation.
A Critical Analysis of Dobbs v. Jackson Women’s Health Organization and the Consequences of Fetal Personhood
Authors: Manninen Bertha Alvarez
Published: January 2023

In this paper, I will examine the Supreme Court of the United States’ (SCOTUS) arguments in the majority decision in Dobbs v. Jackson Women’s Health Organization, and I will show how some of those arguments are flawed. Primarily, I will show that the right to bodily autonomy is a well-established right, both in the courts and in societal practices, and that the right to an abortion should be understood as an example of the right to bodily autonomy or bodily integrity. Second, I will examine the justices’ arguments that viability is not a reasonable place to restrict abortion access, in contrast to both Roe v. Wade and Planned Parenthood v. Casey, and will offer arguments that defend viability as a valid point to limit abortion access. Third, I will highlight some politicians’ goals to enact a federal ban on abortion, and show how the attempt to pass Personhood Amendments is a pathway for doing so. The upshot of this essay to is show how the SCOTUS decision is flawed, and how granting personhood to “potential life” has consequences that extend beyond abortion access.
Intramural course of an anomalous left coronary artery is not always associated with a slit-like ostium
Authors: Montaña-Jimenez Lina Paola , Molossi Silvana , Masand Prakash , Heinle Jeffrey S. , Binsalamah Ziyad , Doan Tam T.
Published: January 2023

Anomalous aortic origin of the left coronary artery from an incorrect aortic sinus has been reported as the second most common causes of sudden cardiac arrest in young athletes. Intramural course of the proximal left coronary artery is considered a high-risk morphology. It is associated with a slit-like ostium and elliptical shape of the proximal artery. In this case, all pre-operative cardiac images demonstrated a round ostium and round luminal shape of the left coronary artery, which suggested no evidence of intramural course. On intraoperative inspection, although the ostium and proximal left coronary artery appeared round, the patient had a long intramural course of the left coronary artery which our surgeons performed a successful unroofing procedure. The post-operative images showed a patent new ostium from the correct aortic sinus. These findings are very unusual and proved that we should not exclude intramural course even in the absence of a slit-like ostium and elliptical shape of the proximal left coronary artery.
Disturbances of phosphatidylcholines metabolism in major depressive disorder
Authors: Wang Yue , Chen Xiangyu , Chen Zhi , Yu Heming , Tian Yu , He Yong , Cheng Ke , Xie Peng
Published: January 2023

Objective

Major depressive disorder (MDD) is a common neuropsychiatry disorder with high prevalence and recurrence rate, but the misdiagnosis rate is inevitable due to the shortage of objective laboratory-based diagnostic criteria. This study is focused on the disturbance of lipid metabolism, providing potential biomarkers for diagnosing.

Methods

Lipid metabolism-related molecules in plasma of 42 drug-naïve MDD patients and 49 healthy people were measured by liquid chromatography-mass spectrometry. Further to evaluate the diagnostic values of changed metabolites, these molecules were evaluated by the receiver operating characteristic curve. Based on the significant role of phosphatidylcholine (PC) disturbance in depression, oxidization of PCs, oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC), IL-8 and caspase-3 in hippocampus, and serum of chronic lipopolysaccharide (cLPS) depression mice were detected by ELISA.

Results

Compared with healthy control, MDD patients expressed higher 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (16:0-16:0 PC, DPPC), 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (16:0-20:4 PC, PAPC), 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine (16:0-18:0 PC), glycocholic acid, taurocholic acid, glycoursodeoxycholic acid, and chenodeoxycholic acid glycine conjugate, and lower 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC 20:0). The 16:0-20:4 PC showed the great diagnostic value for MDD with an area under the curve (AUC) of 0.9519, and combination of 16:0 PC, 16:0-18:0 PC, and 16:0-20:4 PC exhibited the highest diagnostic value with AUC of 0.9602. OxPAPC was certified increase in hippocampus and serum of cLPS depression mice, which further supported PCs disorder participated in depression.

Conclusion

This research offers 16:0-20:4 PC as the latent diagnostic indicator for MDD and hints the important role of PCs in depression.
Epistemic space and key concepts in early and late modern medical discourse: an exploration of two genres
Authors: WHITT RICHARD J.
Published: January 2023

This article provides a corpus-driven overview of the ‘epistemic space’ surrounding the use of two lockwords of Early and Late Modern English writings on midwifery and childbirth,childanduterus. Rather than searching for epistemic stance markers themselves, this study employs the ‘bottom-up’ approach by examining the propositions containing these lockwords, and then seeing what particular epistemic meanings are signalled by the surrounding discourse context. Both treatises and periodicals representative of medical writing from the sixteenth through the eighteenth centuries are examined, thus allowing any diachronic trends characteristic of a period that witnessed much change in midwifery practices, and medicine more broadly, to be uncovered. Data are drawn from theEarly Modern English Medical Texts(EMEMT) andLate Modern English Medical Texts(LMEMT) corpora.
The Impact of Urbanization on Mesoscale Convective Systems in the Yangtze River Delta Region of China: Insights Gained From Observations and Modeling
Authors: Xian Tian , Guo Jianping , Zhao Runze , Su Tianning , Li Zhanqing
Published: January 2023

Urbanization is an important factor that may influence the formation and development of clouds and precipitation. In this study, we focus on studying the influence of urbanization on mesoscale convective systems (MCS) over the Yangtze River Delta region in China under different synoptic conditions using a combination of radiosonde, meteorological station, and satellite observations. It demonstrates that synoptic forcing can be used to distinguish the effect of land cover and land use on MCS. When the synoptic‐scale forcing is weak, the urban heat island (UHI) is the main factor affecting the vertical development of clouds. The UHI decreases atmospheric stability and enhances horizontal convergence, invigorating clouds over and downwind of cities. On the other hand, when strong synoptic‐scale forcing is present, buildings in cities cause clouds to bifurcate upwind of cities, moving around them, primarily through their dynamic effects. The heights of cloud tops in central and downwind parts of cities thus drop. Using the Weather Research and Forecasting model simulations of different atmospheric forcings also demonstrate similar patterns around major urban areas. The joint analyses of observations and model simulations provide new insights into the net effects of urbanization on cloud systems.
The Role of Mineral Dust Aerosol Particles in Aviation Soot‐Cirrus Interactions
Authors: Kärcher B. , Marcolli C. , Mahrt F.
Published: January 2023

Predicting cirrus cloud properties with confidence requires a sound understanding of the relative roles of homogeneous and heterogeneous ice formation. This study explores the effect of mineral dust and contrail‐processed aviation soot particles as ice‐nucleating particles (INPs) competing with liquid solution droplets in cirrus formation. We study aerosol‐cirrus interactions by accounting for atmospheric variability in updraft speeds and INP number concentrations. Our results confirm the dominant role of mineral dust in ice nucleation events in cirrus clouds. In addition, we show that pre‐existing thin cirrus may suppress ice formation when updraft speeds are low. We find that homogeneous freezing of liquid solution droplets dominates clear‐sky aerosol‐cirrus interaction above a threshold updraft speed determined by total number concentrations and ice nucleation abilities of INPs. When mineral dust particles exceed number concentrations of 10 L−1, they reduce homogeneously nucleated ice crystal numbers significantly and even prevent homogeneous freezing for frequently observed local updraft speeds between 10 and 20 cm s−1. When both mineral dust and aviation soot particles coexist with solution droplets, dust typically prevents ice nucleation by aviation soot. Aviation soot exerts a notable impact on cirrus ice numbers only if updrafts are weak, large soot particles are present in number concentrations that are considerably higher than typically observed in emission measurements, and/or number concentrations of mineral dust and other INPs are low. Overall, our results elucidate the role of aviation soot‐cirrus interactions in the presence of other INP types.
Low Sea Surface Salinity Event of the Japan Sea During the Last Glacial Maximum
Authors: Zheng Junyong , Guo Xinyu , Yang Haiyan , Du Kailun , Mao Xinyan , Jiang Wensheng , Sagawa Takuya , Miyazawa Yasumasa , Varlamov Sergey M. , Abe‐Ouchi Ayako , Chan Wing‐Le
Published: January 2023

Abnormal lightening of the oxygen isotope ratio (δ18O) of planktonic foraminifera during the Last Glacial Maximum (LGM, ∼21 kyr BP) suggests that the Japan Sea had experienced a low sea surface salinity event at that time. However, the exact value and timing of minimum salinity have been controversial so far. To address this issue, we adopt a simple box model and reconstruct the sea surface salinity in the Japan Sea (SJP) over the past 35 kyr with a focus on the LGM period. In particular, as input data for the box model, the inflow transport through the Tsushima Strait (Q) is converted from sea level evolution using a newly defined relationship, in which Q reduces non‐linearly with the sea level reduction through a dynamically‐constrained realistic ocean model. Meanwhile, another input data of the box model, sea surface freshwater flux (precipitation minus evaporation (P‐E) evolution), is obtained by averaging multi‐paleoclimate models (PMIP3 and MIROC4m models) results. The reconstructed SJP using the box model reached its minimum value (20.2) at 20 kyr BP with a high coefficient of determination (R2) for δ18O (0.81, p << 0.01). Further analysis demonstrates that the above non‐linear relationship, determined by h3/2 (h is the strait depth), promises a more reasonable reconstruction of the SJP evolution. It is also concluded that both the value and timing of the minimum SJP depend on the Q evolution, and the P‐E evolution can modify the former. Therefore, the combination of Q and P‐E determines the exact value and timing of minimum salinity.