bluuebunny/crossref_metadata_2025 huggingface dataset:
Ordenamiento turístico comunitario: ruta crítica para definirlo
Authors:   Universidad Autónoma de Baja California (México), Ríos-Llamas Carlos , Hernández Vázquez Samuel ,   Universidad Autónoma de Baja California (México)
Published: April 2024

The aim of this paper is to propose a definition of Community Tourism Planning based on a review of the Latin American publications on “territorial planning” and “community tourism” of the last two decades. The analysis consisted of coding with ATLAS.ti for a geographical classification of each of the approaches to community and tourism. The interpretation consists of a double exercise, firstly a mechanism is established to discriminate the documents according to their postulates and secondly a theoretical reflection on the studies. The findings show a discursive displacement from the economic view of tourism that characterized the beginning of the 21st century to a new environmental and cultural perspective with greater geographical diversity. As a final result, the OTC is defined based on five criteria: economic development, citizen participation, territorial planning, environmental conservation and cultural heritage.
Privilegios del sector privado y el discurso desarrollista del turismo. Análisis del contexto internacional y colombiano
Authors:   Universidad Nacional de Colombia (Colombia), Muñoz Arroyave Elkin , López Martínez Alexandra ,   Tecnológico de Antioquia (Colombia), Flórez Laiseca Adriana María ,   Universidad del Quindio (Colombia)
Published: April 2024

The growth of tourism at the international level is the highest in history. As a result, the institutional framework of this activity has positioned a discourse that makes tourism be seen as a source of development for the territories, but what is proposed in the study is that in reality this discourse hides a series of economic interests. Thus, the objective of this article is to identify the economic and political interests that are found within tourism policies or in the developmentalist discourse of tourism. To this end, a critical analysis of the discourse of legislation and official information from institutions at different scales of geographic incidence is carried out. The main result is that support for the economic interests of some central actors is disguised through a series of social ideas that in reality are not fulfilled. In this sense, the contribution and originality of the work focuses on the methodological approach applied from the critical analysis of the discourse to official documents of organizations that lead tourism, to show that there are some interests that are being favored there.
Mediação Cultural à Contrapelo: la acción de la Comunidad Cultural Quilombaque en el ámbito del Patrimonio Cultural
Authors:   Fundação Getulio Vargas (Brasl), Peria Pedro Vianna Godinho
Published: April 2024

The article presents an interpretation of the actions for valorisation of cultural heritage mobilized by the political‐cultural collective Comunidade Cultural Quilombaque. Active in the neighborhood of Perus, in the northwestern area of the Municipality of São Paulo, since 2005, Quilombaque shows itself to be a pole of agglutination of various artistic and political manifestations and of other groups in the territory. In the field of Cultural Heritage, through the consolidation of the Territorial Museum Tekoa Jopo’i and the Queixadas Agency, they have developed a trail of trails that go through the heritage of the people of the neighborhood. In relation specifically to their work in the field of Memory, it is posited that the Museum and the territory are confused, as they transform the territory itself into a museum, while the Agency’s tourism is carried out under the sign of resistance. The symbolic mediation promoted by the Museum’s educators brings out narratives of struggle eclipsed by official cultural heritage policies.
Systematic Literature Review of Health Tourism Innovation
Authors:   Yaşar University (Turquía), Pırna İger , Ozan Hüseyin ,   Yaşar University (Turquía)
Published: April 2024

Innovation is an important issue for any business and especially vital concept for the establishment and growth of a successful health tourism businesses for gaining business improvement and differential advantage in competition. Purpose of this study is to figure out gaps in the innovation in health tourism entrepreneurship literature, show the comprehensive whole situation, areas where the related areas focused on and indicate the related promising areas for research in health tourism innovation. Thus, the significance of this study lies in 2 sub topics as; 1) providing a brief literature review on health tourism innovation 2) indicate the research gaps in health tourism innovation. Results indicate that there is a serious research gap in the innovation studies in spa and wellness tourism, since studies are concentrated on health and medical tourism. Moreover, it is understood that qualitative research is preferred by the majority of the authors followed by the mixed methods which leads to a research gap for quantitative studies in the area. Hence, most researched areas consist of determinants of innovativeness, impact on costs, innovation’s relationship with sustainability, innovation drivers, collaboration, aspects of innovation on success, innovation types’ effectiveness on health tourism establishments and successful innovation applications.
Vigilância epidemiológica do sarampo no estado do Amapá: uma análise dos casos suspeitos no período de 2012 a 2022
Authors: Cruz Nádia Gabriela Leite , Paula Bruna de , Santos Kayse Luane Santiago , Cardoso Rosilene Ferreira , Trindade João Farias da
Published: April 2024

Objetivo: Analisar os casos suspeitos de Sarampo notificados por meio de fichas de investigação no estado do Amapá durante o período de 2012 a 2022. Métodos: Estudo descritivo, quantitativo e transversal, baseado na coleta de dados secundários disponíveis na Superintendência de Vigilância em Saúde (SVS) do Governo do Estado do Amapá, relativos ao período compreendido entre os anos de 2012 e 2022. As variáveis de interesse foram selecionadas e submetidas à análise descritiva, bem como ao teste de associação conhecido como Teste Qui-quadrado (Chi-square test). Resultados: Entre 2012 e 2022 foram notificados 1413 casos suspeitos de sarampo, dos quais 755 foram confirmados, 589 foram descartados, havendo predomínio na faixa etária de menores de um ano. Através do teste qui-quadrado de independência, evidenciou-se associação entre a vacinação para sarampo e as hospitalizações por casos suspeitos, bem como entre vacinação para sarampo e classificação final do caso. Conclusão: Destaca-se o ressurgimento alarmante da doença, especialmente entre grupos vulneráveis, com a queda na cobertura vacinal, influenciada pela pandemia da COVID-19 e pela propagação de movimentos antivacina, que desempenharam papel relevante nesse aumento de casos. Portanto, é urgente enfatizar a conscientização sobre a importância da imunização e aprimorar o acesso aos serviços de saúde.
Imlifidase: Is it the Magic Wand in Renal Transplantation?
Authors: Krishnan Nithya , Briggs David
Published: April 2024

Potential kidney transplant patients with HLA-specific antibodies have reduced access to transplantation. Their harmful effects are mediated by the Fc portion of IgG, including activation of the complement system and Fc receptor-initiated cytotoxic processes by circulating leucocytes. Avoiding antibody incompatibility is the conventional approach, but for some patients this can mean extended waiting times, or even no chance of a transplant if there are no alternative, compatible donors. For these cases, pretransplant antibody removal may provide access to transplantation. Plasmapheresis is currently used to achieve this, with acceptable outcome results, but the process can take days to reduce the antibody levels to a safe level, so has limited use for deceased donors. There is now an alternative, in the form of an IgG-digesting enzyme, Imlifidase, which can be administered for in vivo IgG inactivation. Imlifidase cleaves human IgG, separating the antigen-binding part, F(ab’)2 from Fc. Typically, within six hours of dosing, most, if not all, of the circulating IgG has been inactivated, allowing safe transplantation from a previously incompatible donor. For deceased donor transplantation, where minimizing cold ischaemia is critical, this six-hour delay before implantation should be manageable, with the compatibility testing processes adjusted to accommodate the treatment. This agent has been used successfully in phase 2 clinical trials, with good short to medium term outcomes. While a donation rate that matches demand may be one essential answer to providing universal access to kidney transplantation, this is currently unrealistic. IgG inactivation, using Imlifidase, is, however, a realistic and proven alternative.
Spontaneous union of neglected proximal pole scaphoid fracture: A case report
Authors: Basal Hammam H. , Elnikety Sherif M.
Published: April 2024

Scaphoid fractures are the most common carpal bone fractures and usually occur due to trauma, typically a fall on an outstretched hand. The scaphoid bone is integral to wrist biomechanics, linking the proximal carpal row to the distal row. Neglected scaphoid fractures can lead to significant long-term complications, with degenerative changes likely to occur. The most common consequence of a neglected scaphoid fracture is known as scaphoid non-union advanced collapse, which typically begins within five years following the injury. It is widely accepted that scaphoid fractures, in general, should be treated to avoid long-term complications. Many surgeons aggressively treat proximal pole fractures with surgical fixation due to the high risk of avascular necrosis. Although some surgeons may consider a period of immobilization, none would argue against the need for treatment of proximal pole fractures, either through immobilization or surgical fixation. In this case, we present an instance of spontaneous union of a neglected proximal pole fracture non-union in a mature adult. This report aims to provide awareness of the possible spontaneous union of neglected proximal pole scaphoid fracture. It also challenges the call for acute aggressive surgical intervention in such fractures. Radiographs and magnetic resonance imaging scan images before and after union are presented, along with a review of the available literature.
Design and Construction of a 3-Phase Axial Type BLDC Generator for PLTB
Authors: Hadi Widyono , Rahardi Gamma Aditya , Fathoni Ahmad Nur , Pratama Muhammad Rizal , Firdausi Hasanur Mohammad
Published: April 2024

The need for electrical energy in remote areas to improve community welfare must be a concern for universities. The government's ability to build new electricity sources is very minimal because it requires large infrastructure and costs, but the government continues to strive to develop new power plants. Therefore, it is necessary to strive for innovation to build power plants from renewable energy sources. There is a need to use renewable energy as an alternative to replace electrical energy which is increasingly in crisis. One alternative energy that is easy to make is energy that uses magnetic force as a model for generating electricity. Brushless Direct Current (BLDC) motors are an alternative to current DC motors. This three-phase permanent magnet axial flux generator is specially designed for vertical-type wind turbines. This generator consists of two stators and one rotor. where each stator consists of 9 coils and the magnet used is a neodymium permanent magnet. Based on test results, this generator can produce a voltage of 12.57 VDC with a wind speed of 6.84 m/s. So, it can turn on DC lights and charge DC batteries. This three-phase axial BLDC generator was tested in 3 stages, namely without load, using battery load, and DC-light load with wind conditions depending on natural conditions.
EDUKASI PENANGANAN BENIH CABAI KATOKKON PADA KELOMPOK WANITA TANI LEMBANG SANDANA, TANA TORAJA
Authors: Karuru Perdy , Taufik Muhammad , Kannapadang Sepsriyanti , Pasanda Afra Andre , Gusnawaty HS Gusnawaty HS , Aku Achmad Selamet
Published: April 2024

The katokkon chili plant (Capsicum chinense Jacq.) is a crop commodity that has high economic value. This type of chili is suitable for planting in high-altitude areas such as the Tanah Toraja region. However, its productivity is still low compared to its production potential, which can reach tens of tons/ha. The low level of knowledge and skills of chili farmers is one of the problems in increasing the productivity of katokkon chilies. The service aims to educate katokkong chili farmers in Lembang Sandana on good seed treatment. The methods used are outreach activities, education, and training on how to treat katokkong chili seeds and make appropriate chili seedling media. Pre- and post-tests were carried out to measure the level of success in implementing activities. Socialization carried out with target partners and collaboration resulted in collaborative support by the head of the Lembang and target partners for implementing kosabangsa. The results of education and training show that 94% of target partners have understood and implemented seed treatment methods such as using growth regulators, soaking in warm water (hot water treatment) and sowing seeds in rockwool media, as well as making growing media using a ratio of buffalo manure. , top soil and husk (1:2:1, v/v) appropriately. The education carried out by the kosabangsa service team has increased the level of knowledge and skills of farmers regarding how to treat katokkon seeds properly
Impact of Fish Feed Formulated with Microalgae Biomass in Experimental Tanks with (Oreochromis Niloticus) Tilapia Culture
Authors:   The Center for Research and Assistance in Technology and Design of the State of Jalisco, AC (CIATEJ), México, Ortiz Amira Jacqueline Maldonado , Khandual Sanghamitra ,   The Center for Research and Assistance in Technology and Design of the State of Jalisco, AC (CIATEJ), México, Ahumada Felipe de Jesús Bonilla ,   The Center for Research and Assistance in Technology and Design of the State of Jalisco, AC (CIATEJ), México, Fajardo Jorge Alberto García ,   The Center for Research and Assistance in Technology and Design of the State of Jalisco, AC (CIATEJ), México, Ruiz Rosa Maria Camacho ,   The Center for Research and Assistance in Technology and Design of the State of Jalisco, AC (CIATEJ), México, Bernabe Antia Ivett Alvarez ,   Instituto Tecnológico Superior De Misantla, Tecnológico Nacional de México-Campus Misantla, Veracruz, México
Published: April 2024

This project aims to evaluate a fish feed developed in CIATEJ with little modification, which included algal biomass and vegetal protein. This product was tested at the laboratory scale and the pilot-scale upscaling was needed for use with impact assessment studies in real ambient conditions. This food has antioxidant capacity due to the inclusion of microalgae. Additionally, it is nutritionally balanced with plant-based protein sources, partially replacing fishmeal. The feed, compared to commercial feed, has a higher protein content (5%) and lower fat content (3%). Evaluating this feed was of great importance to corroborate its consumption, which can reduce oxidative stress, reduce water contamination, and improve the growth rate and quality of the meat in fish. FCR values of almost 1 were reported here, indicating the more efficient utilization of formulated feed by Oreochromis niloticus. The main component of tilapia meat was moisture 74.31%, followed by protein 14.44%, lipids 6.24%, carbohydrates 0.10%, fibre 1.39%, and ash 3.62%. in experimental feed. In our results in fish filate, we found a 12% increase in protein percentage and a 29% decrease in fat percentage compared to the commercial feed, as expected from the higher protein and lower fat formulated feed. The amount of protein increment in fish filet we achieved in 2 months, the experimental diets significantly influenced the content of polyunsaturated fatty acids at 2.4% while saturated fatty acids were 1.3%. Omega 6 and Omega 9 were 2.33% and 1.73% respectively. The polyunsaturated fatty acid/saturated fatty acid ratio was also higher.
Transferable diversity – a data-driven representation of chemical space
Authors: Gould Tim , Chang Bun , Dale Stephen , Vuckovic Stefan
Published: April 2024

Transferability, especially in the context of model generalization, is a paradigm of all scientific disciplines. However, the rapid advancement of machine learned model development threatens this paradigm, as it can be difficult to understand how transferability is embedded (or missed) in complex models. While transferability in general chemistry machine learning should benefit from diverse training data, a rigorous understanding of transferability together with its interplay with chemical representation remains an open problem. We introduce a transferability framework and apply it to a controllable data-driven model for developing density functional approximations (DFAs), an indispensable tool in everyday chemistry research. We reveal that human intuition introduces chemical biases that can hamper the transferability of data-driven DFAs, and we identify strategies for their elimination. We then show that uncritical use of large training sets can actually hinder the transferability of DFAs, in contradiction to typical “more is more” expectations. Finally, our transferability framework yields transferable diversity, a cornerstone principle for data curation for developing general-purpose machine learning models in chemistry
Ligand field states control photocatalytic efficiency of transition metal oxides
Authors: Sachs Michael , Harnett-Caulfield Liam , Pastor Ernest , Davies Bernadette , Sowood Daniel J. C. , Moss Benjamin , Kafizas Andreas , Nelson Jenny , Walsh Aron , Durrant James R.
Published: April 2024

Efficient charge extraction in solar energy conversion devices requires materials that are capable of generating long-lived charge carriers. However, carrier lifetimes vary by orders of magnitude between photoabsorbers and there is no blueprint for the targeted design of materials with intrinsically long lifetimes. Here, we establish a fundamental link between the carrier lifetime and the electronic configuration of transition metal oxides (TMOs). By comparing their deactivation pathways across a range of electronic configurations, we identify a sub-ps relaxation mechanism via metal-centred ligand field (LF) states. These LF states open localised recombination channels that compromise charge and quantum yields in open d-shell TMOs (e.g., Fe2O3, Co3O4, Cr2O3, NiO), which is more reminiscent of molecular complexes than crystalline semiconductors. In contrast, in TMOs with d0 or d10 electronic configurations (e.g., TiO2, BiVO4), the absence of LF states enables larger yields of long-lived charges and thus more efficient photocatalysis. Notably, our results suggest that charge localisation in the form of polarons can mitigate rapid LF deactivation. These trends translate to other metal-containing semiconductors and open a new pathway to design absorbers with well-controlled non-radiative recombination channels for applications including photovoltaics, photocatalysis, and communication devices.
Structural Deformations in Cucurbit[n]urils: Analysis, Host-Guest Dependence, and Automated Ellipticity Measurements using ElliptiCB[n]
Authors: Garcia Arman , Shavlik Michael , Harms Michael , Pluth Michael
Published: April 2024

Cucurbit[n]urils (CB[n]s) are cyclic macrocycles with rich host-guest chemistry and can bind a variety of guests, often with high association constants. In many cases, guest binding in CB[n]s results in structural deformations in the host to accommodate guests of different sizes and shapes. Unfortunately, measuring such deformations has remained a major challenge, with only a handful of manual estimations reported in the literature. To address this challenge and to allow for the simple measurement and analysis of CB[n] deformations both in the presence and absence of guests, we have developed the public program ElliptiCB[n], which is available on GitHub, that provides a robust and automated method for measuring the elliptical deformations in CB[n] hosts. We outline the development and validation of this approach, apply ElliptiCB[n] to measure to the ellipticity of the 1113 available CB[n] structures from the Cambridge Structural Database (CSD), and directly investigate the structural deformations of CB[5], CB[6], CB[7], CB[8], and CB[10]. We also report the general landscape of accessible CB[n] elliptical deformations and compare ellipticity distributions across CB[n] hosts and host-guest complexes. We found that in almost all cases guest binding significant impacts the distribution of host ellipticity distributions and that ellipticity distributions are dissimilar across host-guest complexes of differently sized CB[n]s. We anticipate that this work will provide not only be a useful approach for understanding of the flexibility of CB[n] hosts but will also enable future measurement and standardization of ellipticity measurements of CB[n] X-ray and/or computational data.
CeO2 Nanoparticle Doping as a Probe of Active Site Speciation in the Catalytic Hydrolysis of Organophosphates
Authors: Miura-Stempel Emily , Oregon Ashley , De Yoreo James , Chen Chun-Long , Cossairt Brandi
Published: April 2024

Organophosphate hydrolysis is important for degrading environmentally harmful compounds and recovering phosphate ions in biological molecules. CeO2 nanocrystals have been well-studied for dephosphorylation via hydrolysis owing to the accessible and tunable distribution of Ce3+ and Ce4+ ions. However, there remains uncertainty in the literature regarding which surface defect properties direct catalytic activity, such as the Ce3+/Ce4+ distribution, oxygen vacancies, faceting, and dopants, and to what degree they contribute to efficient hydrolysis. Trivalent (M3+) dopants serve as a tool for manipulating defects, including the concentration of Ce3+ and oxygen vacancies, thereby influencing the hydrolytic activity of CeO2. Herein, trivalent metal ions (M = Y3+, Cr3+, In3+, and Gd3+) were employed to modulate the active sites on the CeO2 nanocrystal surface, and the effects of each metal dopant on the cerium oxide active sites for organophosphate hydrolysis were investigated. M-doped CeO2 nanoparticles were synthesized via hydrothermal methods, followed by annealing to remove ligands and prime the nanocrystal surface for catalysis. Catalytic performance was evaluated using dimethyl-p¬-nitrophenyl phosphate (DMNP) as a model organophosphate substrate, with degradation monitored over time using UV-visible absorption spectroscopy. Powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy revealed successful doping of CeO2 in all cases, albeit with distinctive characteristics demonstrating how M3+ dopants affect catalysis. We show that CeO2 exhibits high sensitivity to dopants that generate lattice strain, Ce3+ ions, and oxygen vacancy defects. Consequently, achieving high catalytic efficiency within CeO2 requires a balanced active site ensemble, wherein defects are maintained at optimal concentrations and distributions on the nanocrystal surface.
Investigating Interaction Dynamics of an Enantioselective Peptide Catalyzed Acylation Reaction
Authors: Brauser Matthias , Petzold Katja , Thiele Christina M.
Published: April 2024

Nuclear magnetic resonance (NMR) is a key method to investigate molecular recognition in biomacromolecules and to detect molecular motions on the µs to s timescale revealing transient conformational states. Changes in kinetics of interconversions between those states can be linked to binding, folding or catalytic events. Here, we investigated whether these methods allow detection of changes in the dynamics of a small, highly selective peptide catalyst during recognition of its enantiomeric substrates. The flexible tetrapeptide Boc-L-(π-Me)-His-AGly-L-Cha-L-Phe-OMe, used for the monoacetylation of cycloalkane-diols, is probed at natural abundance using carbon relaxation dispersion in the rotating frame (13C-R1ρ) and proton chemical exchange saturation transfer (1H-CEST). Indeed, we detected differences in dynamics of the peptide upon interaction with the diol. Importantly, these differ depending on the enantiomer of the substrate used providing insights into the recognition of the substrates. These enantiospecific influences of the substrates on the dynamics of the peptide catalyst revealed are rationalized using. computational techniques. Moreover, findings obtained are supported by experimental reaction monitoring of the acetylation reaction.
Cation Vacancies Enable Anion Redox in Li Cathodes
Authors: Kim Seong Shik , Kitchaev Daniil A. , Patheria Eshaan S. , Morrell Colin T. , Qian Michelle D. , Andrews Jessica L. , Yan Qizhang , Ko Shu-Ting , Luo Jian , Melot Brent C. , Van der Ven Anton , See Kimberly A.
Published: April 2024

Conventional Li-ion battery intercalation cathodes leverage charge compensation that is formally associated with redox on the transition metal. Employing the anions in the charge compensation mechanism, so-called anion redox, can yield higher capacities beyond the traditional limitations of intercalation chemistry. Here, we aim to understand the structural considerations that enable anion oxidation and focus on processes that result in structural changes such as the formation of persulfide bonds. Using a Li-rich metal sulfide as a model system, we present both first-principles simulations and experimental data that show cation vacancies are required for anion oxidation. First-principles simulations show that oxidation of sulfide to persulfide only occurs when a neighboring vacancy is present. To experimentally probe the role of vacancies in anion redox processes, we introduce vacancies into the Li2TiS3 phase while maintaining a high valency of Ti. When the cation sublattice is fully occupied and no vacancies can be formed through transition metal oxidation, the material is electrochemically inert. Upon introduction of vacancies, the material can support high degrees of anion redox even in the absence of transition metal oxidation. The model system offers fundamental insights to deepen our understanding of structure-property relationships that govern reversible anion redox in sulfides and demonstrates that cation vacancies are required for anion.
Effect of anemia on oral cavity and hematological assessments
Authors: Mahdi Idan , Hayder , Abdul-Mahdi Hasani , Rafid , Qahtan Othman Ibtehal
Published: April 2024

Background: Anemia is a decrease in the amount of hemoglobin, or red blood cells, in the blood. Slow-onset symptoms, such as dyspnea, exhaustion, weakness, or impaired exercise capacity, are frequently nonspecific. Red blood cells' capacity to carry oxygen is limited by anemia. This suggests that the body's tissues and organs take less oxygen from the blood.
Objective: To determine the effect of anemia on oral cavity in addition hematological assessments and compare them with healthy controls.
Patients and Methods: Among 80 people, a cross-sectional study was conducted. Twenty healthy control participants (9 male and 11 female) and sixty patients with anemia (22 male and 38 female) made up the study samples. Study was directed in September 2023 in Alkhalis hospital-Diyala.
Results: Level of hemoglobin in the control group showed a statistically highly significant increase with mean ± SE (14.12 ±0.35) as compared with patients’ group. The white blood cell counts showed an increase in the control group with mean ± SE (9.92 ±0.54) as compared with patients’ group, with a statistically highly significant correlation. Out of 60 patients, 2 (3.33%) were complaining from angular cheilitis, 6 (10%) were complaining from burning mouth syndrome, 5 (8.33%) were complaining from recurrent aphthous stomatitis, and 13 (21.67%) were complaining from atrophic glossitis, with a statistically highly significant relationship.
Conclusion: Differences in white blood cell counts in patients with anemia and healthy control. Many oral manifestations associated with anemia such as atrophic glossitis, burning mouth syndrome, angular cheilitis, and recurrent aphthous stomatitis.
Renal antiporter ClC-5 regulates collagen I/IV through the β-catenin pathway and lysosomal degradation
Authors: Durán Mònica , Ariceta Gema , Semidey Maria E , Castells-Esteve Carla , Casal-Pardo Andrea , Lu Baisong , Meseguer Anna , Cantero-Recasens Gerard
Published: April 2024

Mutations in Cl−/H+antiporter ClC-5 cause Dent’s disease type 1 (DD1), a rare tubulopathy that progresses to renal fibrosis and kidney failure. Here, we have used DD1 human cellular models and renal tissue from DD1 mice to unravel the role of ClC-5 in renal fibrosis. Our results in cell systems have shown that ClC-5 deletion causes an increase in collagen I (Col I) and IV (Col IV) intracellular levels by promoting their transcription through the β-catenin pathway and impairing their lysosomal-mediated degradation. Increased production of Col I/IV in ClC-5–depleted cells ends up in higher release to the extracellular medium, which may lead to renal fibrosis. Furthermore, our data have revealed that 3-mo-old mice lacking ClC-5 (Clcn5+/−andClcn5−/−) present higher renal collagen deposition and fibrosis than WT mice. Altogether, we describe a new regulatory mechanism for collagens’ production and release by ClC-5, which is altered in DD1 and provides a better understanding of disease progression to renal fibrosis.
Modification of the GLITEROS diabetes-specific hospital enteral formula based
on jicama flour and tempeh flour with the addition of sunflower seed flour
Authors: Wijayanti L. , Muniroh M. , Al-Baarri A.N. , Fitranti D.Y. , Mahati E> , Afifah D.N.
Published: April 2024

The diabetes-specific enteral formula is necessary to assist glycemic control for critically
ill diabetic patients. The GLITEROS enteral formula is an innovative diabetes-specific
hospital enteral formula made from local food, jicama flour and tempeh flour. However,
the fat content in the GLITEROS enteral formula does not meet the fat requirements for a
diabetes-specific enteral formula. Sunflower seeds are a good food source of
monounsaturated fatty acids, specifically oleic acid which has antidiabetic effects. The
addition of sunflower seeds to the GLITEROS enteral formula as a modification can
optimize the lack of fat content. This study aimed to analyze the macronutrient content,
dietary fiber, protein digestibility, and physical properties, including viscosity and
osmolality of the modified GLITEROS enteral formula. This research was an
experimental study with four formula groups, Formula A, B, C, and D, with different
ratios of tempeh flour, jicama flour, and sunflower seed flour; (1:1:1), (1:1:2), (1:2:1), and
(2:1:1). The variables of this study were energy density, calories, carbohydrates, fat,
protein, dietary fiber, protein digestibility, viscosity, and osmolality were tested with three
repetitions in duplicate. Data analysis used One-way ANOVA and the Kruskal-Wallis test.
Formula B had the highest density of energy, energy, fat, and dietary fiber compared to
the four formulas. Meanwhile, Formula C had the highest protein content and digestibility
value compared to other formulas. The highest viscosity and osmolality values were in
formula A. Formula C was the most qualified formula in terms of macronutrient content,
dietary fiber, protein digestibility, and physical properties of diabetes-specific enteral
formulas according to the requirements of the American Diabetes Association (ADA),
Canadian Diabetes Association (CDA), American Society of Parenteral and Enteral
Nutrition (ASPEN)
Okul Öncesi Dönem Çocukları ve İlkokul Öğrencilerinin Teknoloji Kullanım Düzeylerinin İncelenmesi (Investigating Digital Technology Usage of Preschool and Primary School Students)
Authors: Yıldız Kevser Helin , Akyel Yakup
Published: April 2024

Bu araştırmanın amacı, okul öncesi dönem çocukları, ilkokul öğrencileri ve velilerin bilgi ve iletişim teknolojilerini kullanım düzeylerini belirlemektir. Araştırmada cinsiyet, yaş, sınıf düzeyi, ailenin eğitim durumu, gelir düzeyi ve çocuk sayısı gibi değişkenler ve eğitim kademesi ile teknoloji kullanımları incelenmiştir. Araştırma nicel araştırma yöntemlerinden kesitsel tarama araştırmasına uygun olarak yürütülmüştür. Araştırmanın çalışma grubu, Kırşehir il merkezinde bulunan dördü anaokulu ve biri ilkokul olmak üzere beş devlet okulunda öğrenim gören 400 okul öncesi dönem çocuğu, 407 ilkokul 1, 2, 3 ve 4. sınıf öğrencisi ve 805 veliden oluşmaktadır. Araştırmanın sonucunda, öğrencilerin teknoloji kullanım düzeylerinin yüksek olduğu ve zengin bir teknolojik çevrede yaşadıkları tespit edilmiştir. Çocukların yaygın teknolojik araç olan televizyon ile uzun zaman geçirdikleri, buna karşın en az olarak bilgisayara vakit ayırdıkları görülmektedir. Bu çalışma, okul öncesi ve ilkokul öğrencilerinin teknoloji kullanım düzeylerini ve bu kullanımın çeşitli değişkenlere bağlı farklılıklarını analiz ederken, aynı zamanda ileriki araştırmalar için geniş bir çerçeve sunarak, özellikle ebeveyn tutumları ve farklı eğitim türlerindeki çocukların teknoloji kullanımları üzerine daha fazla araştırma yapılmasının gerekliliğini vurgulama konusunda öneriler getirmektedir. Bu çalışma ikinci yazarın danışmanlığında Okul Öncesi ve İlkokul Öğrencilerinin Teknoloji Kullanım Düzeylerinin İncelenmesi adlı yüksek lisans tezinden üretilmiştir.
Application of Network Pharmacology to Explore the Anti-Aging Molecular Mechanism of Radix notoginseng
Authors: Zhang Junyang , Yu Qinglin , Zhao Tong , Ding Xueru
Published: April 2024

Objective: To study the anti-aging effects of Radix Notoginseng and to explore its molecular network mechanism. Methods: Aging and Radix notoginseng gene targets were searched and downloaded from the Genecards website, then Venn intersection analysis was performed to find common genes for diseases and drugs to explore candidate targets for Radix notoginseng in the treatment of aging. Bioinformatics was then used to analyze the biological processes, cellular components, molecular functions, and KEGG signaling pathways of the shared target network. Protein molecular network construction was carried out to find the core molecular network genes of the drug Radix notoginseng for the treatment of aging. A final PubMed literature comparison was performed to assess the value of the potential role of core network genes. Results: The keywords “Aging” and “Radix notoginseng” were queried in Genecards and 25,000 aging-related targets were obtained, 17 for Radix notoginseng. GO and KEGG analysis of the intersecting genes obtained from the Venn intersection analysis then showed that the BP with the highest potential to be associated with disease and drugs is positive regulation of protein phosphorylation, CC is macromolecular complex and MF is identical protein binding. The KEGG with the higher correlation is lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, and proteoglycans in cancer. A total of 10 hub genes were identified in the PPI network construction, including EGFR, MMP9, TNF, VEGFA, RHOA, CDKN1A, CASP3, CCND1, AKT1, and IL1B. Among these, it found that a large number of MMP9 and TNF genes were reported in the literature, with the remaining hub genes less frequently reported in the literature. Conclusion: This study uses bioinformatics and network pharmacology to explain the core network mechanisms of the drug Radix notoginseng in the treatment of aging using the latest databases. The results show that hub genes such as CDKN1A, EGFR, and AKT1 are involved in the core biological processes of aging. The results of the study provide an important reference for resolving the core molecular network mechanism of anti-aging properties and provide a validation basis for future experimental validation.
Kinds of Mathematical Thinking Addressed in Geometry Research in Schools: A Systematic Review
Authors: Fachrudin Achmad Dhany , Juniati Dwi
Published: April 2024

Geometry is one of the content of mathematics which in many studies is associated with students' thinking abilities, such as critical thinking and reasoning abilities or others..This study aims to conduct a systematic review of the geometry research in school for identifying the types of mathematical thinking and their interconnections. We searched the Scopus database for articles published from 2003 to 2023 using relevant keywords. We applied the PRISMA method to select and evaluate the studies or articles based on the empirical data. We retrieved and evaluated data from the studies on the various styles of mathematical thinking evolved. Out of 166 titles that were initially obtained, only 10 titles passed the five stages of the systematic review protocol process. We identified 10 types of mathematical thinking that were discussed in the context of learning geometry at school: Creative Mathematical Reasoning (CMR), Computational thinking, Geometric reasoning, Geometric thinking van hiele theory, Geometric thinking (3D geometric thinking with representations), 3D geometry thinking, Visuo spatial reasoning, Geometry Spatial Reasoning, mathematical creative reasoning (MCR), and Inductive reasoning. We also found some connections of literature between these types of mathematical thinking, such as CMR and MCR, Geometric reasoning and Geometric thinking, and Visuo spatial reasoning and Geometry Spatial Reasoning. This systematic review provides an overview of the current state of research on geometry and reasoning in school mathematics and reveals some gaps and directions for future study. It also has implications for teachers who want to enhance their students’ mathematical thinking skills in geometry by exposing them to different types of mathematical thinking and their connections.
Musical and Aesthetic Education of Children and Youth in the a Cross-Cultural Space of the Republic of Malta
Authors: Cherkasov Volodymyr
Published: April 2024

The article attempts to investigate and generalize the experience of musical and aesthetic education, the organization of general musical education of children and youth in the cross- cultural environment of the Republic of Malta. On the basis of the analysis of the program material, the priority types of activities in the lessons and during the organization of extra curricular work on artistic and aesthetic education were considered. Particular attention is paid to vocal and choral work, study and performance of folk songs, as well as involving students in familiarizing themselves with the works of domestic and foreign composers, forming worldviews in children and young people by means of musical art.

It has been proven that students are active and resourceful, independently find and present folk songs in lessons that they have heard performed by members of their families or acquaintances of the older generation. A dominant role in music lessons is played by listening to and analyzing the musical works of classical composers and studying the work of Maltese composers. Composers and their works are presented, which are included in music education programs.
KARATE-DO TƏLİMİNİN TƏLİM-MƏŞQ TEXNOLOGİYASINDA TƏDRİS PROBLEMLƏRİ
Authors: U.M. Aghaeva
Published: April 2024

Məqalədə gənc karateçilər üçün eksperimental təlim proqramının həyata keçirilməsi prosesi müzakirə olunur. Bundan əvvəl mövcud sosial-iqtisadi, siyasi və mədəni vəziyyətin ən mühüm xüsusiyyətləri qeyd etdirilir. Araşdırmalar nəticəsində sübut edilmişdir ki, belə şəraitdə əlavə təhsil sistemi istər-istəməz bir sıra köklü dəyişikliklərə məruz qalmalıdır. Perspektivli pedaqoji texnologiyaların tədris prosesinə inteqrasiyasının əlavə təhsil sisteminin gələcək inkişafını təmin edən imkanlar araşdırılır. Bir sıra müəlliflər tərəfindən təklif olunan gənc karateçilər üçün təlim proqramının əsas xüsusiyyətləri təsviri təhlil edilərkən, pedaqoji eksperimentin vasitəsilə onun effektivliyi yoxlanılır. Bu təhsil və təlim prosesinə inteqrasiyası perspektivləri ilə bağlı bir sıra nəticələri üzə çıxarır.
The Reflexive Condition on Skew Monoid Rings
Authors: Ali Eltiyeb
Published: April 2024

This paper is devoted to introducing and studying two concepts, σ-skew strongly M-reflexive and σ-skew strongly M-nil-reflexive on monoid rings, which are generalizations of strongly M-reflexive and M-compatible. The paper covers the basic properties of skew monoid rings of the form R∗M. It is shown that if R is a left AP P (quasi Armendariz, semiprime rings, respectively), then R is σ-skew strongly M-reflexive. Moreover, if R is a NI-ring and M is a u.p-monoid, then R is σ-skew strongly M-nil-reflexive. Additionally, under some necessary and sufficient conditions, a skew monoid ring R ∗ M is proven to be σ-skew strongly M-nil-reflexive when σ : M → Aut(R) is a monoid homomorphism. Furthermore, if R is a left AP P, then the upper triangular matrix ring Tn(R) is σ ̄-skew strongly M-nil-reflexive, where n is a positive integer. Finally, the paper provides some examples and discusses related results from the subject.
Analisis Faktor-Faktor Yang Memengaruhi Pengeluaran Rumah Tangga Petani Padi Sawah di Kabupaten Aceh Utara
Authors: Martina Martina , Praza Riyandhi , Adhiana Adhiana
Published: April 2024

Kabupaten Aceh Utara merupakan wilayah sentra produksi padi sawah  di Provinsi Aceh dengan luas tanam  mencapai 75.800 Ha dengan produksi 389.945,41 ton. Sebagian besar masyarakatnya memiliki pekerjaan sebagai petani padi sawah. Jumlah penduduk Kabupaten Aceh Utara sebanyak 556.566 jiwa, dan sekitar 27,56 persen merupakan penduduk miskin. Kesejahteraan rumah tangga petani dapat diketahui dari besarnya pengeluaran rumah tangga petani padi sawah yang dipengaruhi oleh beberapa faktor antara lain pendapatan,  luas lahan usaha tani, jumlah tanggungan, jumlah anak yang masih sekolah, dan umur kepala keluarga. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang memengaruhi pengeluaran rumah tangga petani padi sawah di Kabupaten Aceh Utara. Responden dalam penelitian ini sebanyak 60 kk dengan analisis data mengunakan model analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa secara simultan variabel pendapatan, luas lahan, jumlah tanggungan, jumlah anak masih sekolah, dan umur kepala keluarga berpengaruh signifikan terhadap pengeluaran rumah tangga petani padi sawah di Kabupaten Aceh Utara, sedangkan secara parsial hanya variabel pendapatan dan jumlah tanggungan yang berpengaruh signifikan terhadap pengeluaran rumah tangga petani padi sawah
PERSEPSI PETANI DALAM PENERAPAN GOOD AGRICULTURE PRACTICES (GAP) KOMODITI BENGKUANG (Pachyrhizus erosus) DI KECAMATAN BINJAI SELATAN
Authors: Pakpahan Tience Elizabet
Published: April 2024

Farmer’s perception in Applicating Good Agriculture Practices (GAP) for yam commodity (Pachyrhizus erosus) in South Binjai, Binjai City. The purpose of this study are : (1) Identify the level of farmer’s perception in applicating Good Agricultural Practices  (GAP) for yam commodity, (2) Identify factors that influence farmer’s perception (education, experience, income, information access, the role of extension worker, participation in extension, technical cultivation) in applicating Good Agricultural Practices (GAP) for yam commodity. This study was held in Binjai on 26 March until 04 Mei 2018. Methods of data collection are surveyed using the questionnaire as data collecting tool and SPSS for Windows 18 program as analyst data processing for identifying factors that influence farmer’s perception in applicating GAP for yam commodity. The results of study shows that level of farmer’s perception is high categorized (87,09%). The results of multiple linear regression is Y’ = 7,071 + 1,040𝑋1+1,666𝑋2 – 0,174 𝑋3 – 0,121 𝑋4+ 0,624 𝑋5+ 0, 087𝑋6 +0,402𝑋7, education, experience, and technical cultivation significanty effected farmer’s participation in applicating Good Agriculture Practices (GAP) for yam commodity, while income, informtion access, the role of extension worker and participation in extension did not significantly effected farmer’s participation in applicating Good Agriculture Practices (GAP) for yam commodity.
KEBERLANGSUNGAN PRODUKSI GULA AREN INDONESIA: KAJIAN PUSTAKA
Authors: Simamora Liska
Published: April 2024

Permintaan gula aren semakin meningkat karena masyarakat sudah cenderung menyukai penyedap rasa  alami. Penyedap rasa alami dan asli memiliki reputasi lebih sehat dan lebih aman daripada bahan sintetis. Penelitian ini akan menguraikan salah satu jenis bahan penyedap rasa  yaitu gula aren yang dikenal sebagai pemanis alami. Negara maju mulai mengimpor gula aren sebagai pemanis alami dari negara berkembang. Produksi gula aren di negara berkembang memiliki peran penting bagi perekonomian rumah tangga. Peningkatan permintaan yang tidak dapat dipenuhi oleh produksi gula aren terutama disebabkan oleh kurangnya pengetahuan petani dan pengrajin gula aren serta rendahnya adopsi teknologi baik untuk budidaya pohon aren maupun proses pembuatan aren. Studi kajian pustaka ini bertujuan untuk memahami keberlangsungan produksi gula aren dengan kerangka kerja yang terdiri dari empat langkah: (1) mengidentifikasi situasi saat ini, (2) mengidentifikasi masalah, (3) penyelesaian masalah, (4) menyampaikan program dan strategi. Berdasarkan kerangka tersebut dihasilkan beberapa program dan strategi untuk menjaga keberlangsungan produksi gula aren antara lain:  Pembudidayaan pohon aren, pengadaan pusat penelitian dan pengembangan gula aren Indonesia, membangun kolaborasi yang baik di antara para pemangku kepentingan yang terlibat.
DALAM MEMUDAHKAN PENGELOLAAN DATA LADA DI BANGKA BELITUNG (MUNTOK WHITE PEPPER)
Authors: Atmaja Eddy Jajang Jaya
Published: April 2024

ABSTRACTThe Province of the Bangka Belitung Islands has long been known as the main producer and exporter of pepper (Piper nigrum L) in Indonesia. The problem that often arises is the low pepper price that is detrimental to farmers and the price reference that follows the price of the International Pepper Community (IPC). Therefore, the Government established the Bangka Belitung Pepper Joint Marketing Office (KPB) to regulate pepper prices as well as the pepper buying and selling process and ensure that the pepper sent is quality pepper since 2019. KPB has had a positive impact on pepper prices and the pepper trading process and received verified seller and buyer data of pepper. This study aims to examine the role and influence of the Pepper Bangka Belitung Joint Marketing Office (KPB) and the KPB system for pepper farmers, starting from prices, stocks, export data, seller data, buyer data and Geographical Indications (GI) which is a guarantee that the pepper Shipped original from Bangka Belitung.
PENGARUH PEMBERIAN BIOWASH BERBAHAN KULIT UMBI DENGAN VARIASI DOSIS TERHADAP KANDUNGAN PROTEIN DAN BERAT KERING TANAMAN AZOLLA PINNATA
Authors: Meilani Ifa ana Meilani
Published: April 2024

Azolla pinnata adalah salah satu tanaman yang memiliki kandungan protein yang tinggi, sehingga sangat cocok untuk ditambahkan ke dalam pakan ternak. tanaman Azolla pinnata dapat menjadi salah satu solusi dalam mengatasi masalah harga pakan yang mahal .Maka dari itu pemberian biowash berbahan kulit umbi diharapkan sangat mendukung pertumbuhan dan perkembangan Azolla pinnata.Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian biowash berbahan kulit umbi dengan variasi dosis terhadap kandungan protein , berat basah dan berat kering Azolla pinnata .Metode dalam penelitian ini adalah eksperimen menggunakan desain penelitian rancangan Acak Lengkap/RAL 4x4 dengan empat perlakuan dan empat pengulangan yaitu sebagai berikut P0 : biowash 0 ml/L air sungai .P1 : biowash 25 ml/L air sungai P2 : biowash 35 ml/L air sungai P3 : biowash 45 ml/L air sungai. Parameter dalam penelitian ini adalah kandungan protein ,berat basah tanaman Azolla pinnata  dan berat kering tanaman Azolla pinnata . Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa biowash berpengaruh untuk mendukung pertumbuhan tanaman Azolla pinnata , hal tersebut dapat dilihat dari bertambahnya kandungan protein pada tanaman Azolla pinnata , berat basah tanaman Azolla pinnata dan berat kering tanaman Azolla pinnata.Kata kunci: Azolla pinnata ,Biowash ,Kandungan protein