bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ACTIVITY OF ANGIOTENSIN-CONVERTING ENZYME 2 AND OTHER COMPONENTS OF THE RENIN-ANGIOTENSIN SYSTEM (RAAS) DURING PROGRESSIVE AGE IN HYPERTENSIVE MEN
Authors: Khalifa Ahmed Aboud , Hasan Methaq Mohamed
Published: April 2023

Background: ACE2 and renin-angiotensin-aldosterone system (RAAS) are complex physiological systems that contribute to blood pressure control, whereas the activity and responsiveness of the ACE2 and RAAS be changed due to advanced age and hypertension. Aim: This study is to investigate the ACE2, Renin, Ang I, Ang II, and aldosterone levels in various ages of hypertensive men in order to provide insights into the effect of aging and high blood pressure on some body organs. Methods: It was compared ACE2, Renin, Ang I, Ang II, and aldosterone levels across 80 hypertensive men with ages between 30 years - 69 years. The persons were divided into four groups (20 men/group) according to their ages. The first group was 30-39 years, the second group was 40-49 years, the third group was 50-59 years, and the fourth group was 60-69. It used a one-way Analysis of Variance (ANOVA), followed by Duncan s test for the groups. Results: It was observed that the concentration of ACE2 decreased significantly in different groups with advanced age (p ≤ 0.01), except in the fourth sample group vs. the third group. The renin was reduced considerably in other groups with aging (p ≤ 0.01), except in the second sample group vs. the first group. The peptides Angiotensin I (Ang I) and Angiotensin II (Ang II) had opposite growth directions, decreasing and increasing, respectively, it was statistically significant (p ≤ 0.01). Also, aldosterone increased significantly in different groups with advanced age (p ≤ 0.01), not including the fourth group vs. the third group). Discussion: The physiological impact of these results is discussed according to the effects of hypertension and advanced age on all the studied parameters, particularly ACE2 deficiency and high levels of Ang II, pointed out an apparent dysfunction in blood pressure regulation during advanced age. Conclusions: ACE2 deficiency may be mediated by a series of dysfunctional events caused by the present changes in RAAS and other parameters in response to hypertension and advanced ages. Low renin levels and other following changes might cause an imbalance of Ang I and Ang II ratios. In addition, high levels of Ang II might reflect the unfavorable and negative changes that contributed to the disruption of many organs and systems during hypertension and advanced age.
DESCRIPTION OF THE STUDY OF SOILS IN DIDACTIC BOOKS FOR THE EARLY YEARS OF ELEMENTARY SCHOOL
Authors: Souza Katiane de Jesus , Menezes Wanderson de Oliveira , Ribeiro Roure Santos , Souza Rômicy Dermondes , Rodrigues Nubia Fernanda Marinho , Gomes Paulo Roberto Barros , Louzeiro Hilton Costa
Published: April 2023

Background: The "soil" content is presented gradually in the early years of elementary school, one of the resources most used as support in basic education is the textbook, which through the National Plan of Book and Didactic Material, was evaluated carefully before being released for selection of schools and education professionals. Aim: This study aims to describe aspects of the "soil" content in four science textbooks for the third year of elementary school. Methods: Documentary analysis followed Bardin’s model. In the pre-analysis, the materials were organized in L1, L2, L3, and L4 followed by floating reading to identify the descriptive and content support elements. The practical activities were classified according to Campos and Nigro, based on the participation of students and teachers in their development. The images were analyzed based on Gestalt pregnancy theory. Results: The analyzed books present respectively 18, 30, 18, and 17 pages destined to the content, where it was possible to identify the presence of definitions, practical activities, and contextuality of the images, although some have neglected relevant aspects. Discussion: The materials use different methodologies, which favor the cognitive development of the student. However, none of the books has information on the main types of soils in Brazil besides presenting limitations on soil classification and science. Conclusion: We conclude that the textbooks of elementary school analyzed present the soil content in its structure, with definitions through texts and images, to an appropriate extent and present relevant proposals for practical activities.
Типология региональных траекторий достижения национальных целей развития в России
Authors: Блануца Виктор Иванович
Published: March 2023

Целью исследования является идентификация групп российских регионов с разными типами траекторий достижения национальных целей развития по каждому показателю и по всему множеству показателей. Исходные данные взяты из приложения к правительственному документу «Единый план по достижению национальных целей развития Российской Федерации на период до 2024 года и на плановый период до 2030 года». По особенностям траекторий достижения показателей в регионе определены восходящие, нисходящие и боковые тренды. Предложена мера расстояния между регионами в многомерном пространстве всех показателей. С помощью авторского алгоритма группировки регионов выявлены два типа многомерной траектории. Распределение регионов по двум типам сформировало специфическую территориальную структуру в виде западной и восточной зоны второго типа, разделенных пространством первого типа и частично оконтуренных фрагментами этого пространства вдоль государственной границы России. Выделены проблемные регионы и определены особенности пространственной автокорреляции регионов. Типы региональных траекторий позволяют оценить будущую неоднородность российского социально-экономического пространства, которое сформируется в результате реализации национальных целей развития к 2030 году. Полученные результаты могут использоваться для корректировки национальных целей и мониторинга выполнения графика достижения целей. Предложено семь направлений дальнейших исследований.

 

БлагодарностиИсследование выполнено за счет средств государственного задания (№ регистрации темы АААА-А21-121012190018-2).
MHD: Mental Health Directory for Nigerian Schools
Authors: Omeiza Cecilia
Published: April 2023

Nigeria has been considered to have the highest number of depression cases in Africa. Young people, such as secondary school students are not exempt. While this is meant to be a serious public health concern, topics around student mental health are still largely ignored. In fact, there exist little or no efforts around the deployment of technological tools to propagate knowledge and create awareness among students in many local communities. In this paper, I propose Mental Health Directory (MHD), a knowledge repository about mental health to help secondary schools better assist teachers and students who might want to learn more about mental illnesses in schools where the internet is not accessible. MHD was developed through the application of information retrieval theories to source and aggregate content from verified online sources. MHD is made publicly available online and offline for schools to utilise for the aforementioned benefit, and as well as a teaching aid, and support for students who might likely be suffering from mental illnesses.
Hepatocorrective effects of Hydroethanolic Extract of Cocos nucifera L. sprout and Borassus flabellifer Sprout in Carbon tetrachloride (CCl4) induced hepatotoxic rats
Authors: Sumi P. , Thangavelu K. , Kumari S. Senthil
Published: April 2023

The objective of the study was to determine the hepatocorrective activity of hydroethanolic extract of Cocos nucifera L. and Borassus flabellifer sprout in carbon tetrachloride (CCl4) induced hepatotoxic rats. The qualitative phytochemical analysis was used to evaluate the secondary metabolites like flavonoids, saponins, proteins in the hydroethanolic extract of Cocos nucifera L. sprout and Borassus flabellifer sprout which also reveals the presence of pharmacologically active phytochemicals. The toxicant CCl4 was used to induce hepatotoxicity in 1 : 1 mixture with olive oil. Hydroethanolic extract of Cocos nucifera L. sprout and Borassus flabellifer sprout were administrated in the doses of 100mg/kg and 200mg/kg body weight orally for 21 days. Silymarin was used as a standard drug. The hepatocorrective effect of the extracts were evaluated by the assessment of biochemical parameters and liver markers such as Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Gamma glutamyl transferase (GGT), Lactate dehydrogenase (LDH), and also by the assessment of Total protein, Creatinine, Urea, Total cholesterol, Lipid peroxidation (LPO), Vitamin C, Superoxide dismutase (SOD), Catalase, Prothrombin Time (PT), Glutathione peroxidase (GPx), Reduced glutathione (GSH) etc. Assessment of enzymatic and nonenzymatic antioxidants and histopathological studies of liver were also done for the hepatocorrective activity determination. Treatment of rats with hydroethanolic extract of Cocos nucifera L. and Borassus flabellifer sprout significantly reduced the liver damage and the symptoms of liver injury by restoration of architecture of liver. The overall findings suggest that both sprouts have potent hepatocorrective activity in carbon tetrachloride induced hepatotoxic rats.
The Role of Lipid Profile Assessment in Monitoring the effect of Imiglucerase in Children with Gaucher Disease
Authors: Ihsan Awadh Ammar
Published: April 2023

Background: Gaucher disease (GD) is an autosomal recessive hereditary illness. Many biomarkers may have a role in the etiology, pathophysiology, diagnosis, and prognosis of GD in children, which is linked to difficulties owing to the involvement of multiple organs, including the liver, spleen, and bones. Objectives to: evaluate the impact of lipid profile levels in monitoring the response to the treatment for GD patients who are on enzyme replacement therapy. Methods: A case control study was done on sixty-seven children suffered from GD recruited from Children Welfare Hospital Consultation Clinic, Gastroenterology and Hepatology Teaching Hospital and Central Child’s Teaching Hospital. The levels of total cholesterol, triglyceride, LDL-C and HDL-C were determined in GD patients’ samples who were classified according to the duration of receiving treatment into four groups, first group include 9 newly diagnosed un treated patients, second group include 18 patients receiving treatment for 3-6 months, third group comprise 20 patients received treatment for 6-12 months (n=20) and fourth group include 20 patients received ERT for more than one year and compared with a control group comprise twenty age and sex-matched control subjects. The practical part of the study was conducted at research laboratories in the Department of Pharmacy, Al-Kunooze University College, Basra-Iraq during the period from November 2021 to February 2022. Results: The results showed that triglyceride (TG) levels in whole Gaucher patients were significantly greater than in age-matched controls, whereas total cholesterol and HDL-C levels in patients were significantly lower than in controls. Non-significant variations in LDL-C levels, on the other hand, were observed. The negative significant correlations between the levels of TG and the period of receiving treatment and the positive significant correlations between the levels of total cholesterol and the period of receiving treatment revealed that these parameters were remarkably associated with the period of receiving ERT treatment. The effect of ERT was also demonstrated by the results of the ANOVA test, which revealed significant variations in the levels of TG and HDL-C across the patient subgroups. Conclusions: TG and HDL-C have been shown to have diagnostic significance in newly diagnosed untreated individuals with a wide range of treatment responses, limiting their utility in treatment monitoring whereas LDL-C showed to be neither affected by the disease nor by the treatment.
Comparison of Meniran (Phyllanthus niruri Linn.) Extract and Sambiloto (Andrographis paniculata Ness.) Extract on Blood Profile of Animal Model Infected with Salmonella
Authors: Hidanah Sri , Sabdoningrum Emy Koestanti , Rachmawati Kadek , Kurnijasanti Rochmah , Soeharsono Soeharsono , Anggraini Sylvia
Published: April 2023

Salmonella Pullorum is the cause of Pullorum disease. The misuse of antimicrobials has resulted in the evolution of resistant strains. Meniran (Phyllanthus niruri Linn.) and Sambiloto (Andrographis paniculata Ness.) contain compounds that are efficacious as antibacterial and immunomodulatory. This study aims to analyze the comparison of meniran extract and sambiloto extract on the blood profile of broiler chickens infected with Salmonella Pullorum. This study was conducted by making Meniran and Sambiloto extracts. Phytochemicals screening (alkaloids, tannins, saponins, flavonoids, andrographolide, steroids and triterpenoids) of extracts, isolation and identification of Salmonella Pullorum and in vivo study were then conducted. The in vivo study was experimental research with completely randomized design that divided broiler chickens into treatment groups: P0- (chickens were not infected), P0+ (chickens were infected with Salmonella Pullorum), PAB (chickens were infected with Salmonella Pullorum and given Enrofloxacin Antibiotics) then treatment P1 Meniran, P2 Meniran, P3 Meniran (chickens were infected with Salmonella Pullorum and, in order, given meniran extract of 5%, 10% and 20% concentrations) and P1 Sambiloto, P2 Sambiloto, P3 Sambiloto (chickens were infected with Salmonella Pullorum and, in order, given sambiloto extract of 5%, 10% and 20% concentrations). Data in the form of blood profile was then analyzed statistically by ANOVA test and continued with Duncan's test. This study shows that Meniran and Sambiloto extract has immunomodulator properties that have good impact in restoring blood profile of broiler chickens infected with Salmonella Pullorum. The comparison shows that Meniran extract has better antibacterial activity on blood profile of broiler chickens infected with Salmonella Pullorum compared to Sambiloto extract.
Pengaruh Variasi Panjang Serat Tebu Sebagai Bahan Tambah Terhadap Indeks Perendaman Campuran AC-BC
Authors: Pareang Armin , Alpius  , Tanan Benyamin
Published: April 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variasi  panjang serat tebu terhadap indeks perendaman campuran  AC-BC ketika digunakan sebagai bahan aditif. Serat tebu ialah limbah organik yang dihasilkan oleh paprik gula. Dalam penelitian serat tebu di manfaatkan sebagai bahan tambah pada campuran aspal sebgai bahan pengikat aspal.. Melalui pengujian perendaman Marshall diperoleh campuran AC-BC dengan variasi panjang serat tebu 3 cm, 4 cm, 5 cm, 6 cm dan 7 cm terhadap durasi perendaman 0,5 jam dan 24 jam. Metode ini menggunakan beberapa uji pada karakteristik material agregat, dan filler, setelah itu dilakukan perancangan untuk campuran AC-BC dan dilakukan uji perendaman Marshall agar dapat diperoleh nilai indeks perendaman (IP),Indeks kekuatan sisa (IKS) dan durabilitas. Dari hasil pengujian tersebut dengan menggunakan metode uji perendaman Marshall  dalam waktu  0,5 jam dan 24 jam maka didapatkan campuran AC-BC dengan variasi panjang serat tebu 3 cm, 4 cm, 5 cm, 6 cm, dan 7 cm. Hasil pengujian Marshall campuran AC-BC memperoleh Indeks Perendaman (IP), Indeks Kekuatan Sisa (IKS), dan Durabilitas yang dari pengujian tersebut didapatkan nilai IP rata-rata variasi panjang serat 3 cm yakni 93,20%, pada variasi panjang serat tebu 4 cm yaitu 93,35% pada variasi Panjang serat tebu 5 cm yaitu 95,15% pada variasi panjang serat tebu 6 cm yaitu 95,81% dan pada variasi panjang serat tebu 7 cm yaitu 98,92%.
Đặc điểm dịch tễ học lâm sàng và căn nguyên ở bệnh nhân nghi ho gà tại Bệnh viện Bệnh Nhiệt đới Trung ương
Authors: Thư Nguyễn Kim , Duyệt Lê Văn
Published: March 2023

Bệnh ho gà là bệnh truyền nhiễm cấp tính, lây qua đường hô hấp, gặp ở mọi lứa tuổi, chủ yếu < 5 tuổi. Thời gian ủ bệnh từ 2 - 30 ngày, bệnh tiến triển qua các giai đoạn, biến chứng gồm viêm phế quản-phổi, ho, lồng ruột, sa trực tràng, viêm não. Mặc dù đã có vắc xin, nhưng tỷ lệ mắc và biến chứng vẫn cao. Mục đích nghiên cứu là mô tả đặc điểm lâm sàng và căn nguyên gây bệnh ho gà tại Việt Nam. Kết quả tìm thấy Bordetella pertussis ở 19% bệnh nhân, có 86,6% < 1 tuổi, nam/nữ là 1,9/1. Triệu chứng gồm ho cơn kéo dài, viêm long, nôn, trớ, thời gian nhập viện trung bình là 13,6 ngày. Các biến chứng gồm viêm phế quản - phổi, phù mi mắt và bội nhiễm, tỷ lệ mắc lên tới 63,4% ở nhóm chưa tiêm vắc xin. Trong năm đều có bệnh nhân mắc bệnh, cao nhất từ tháng 3 - 6. Bệnh ho gà vẫn lưu hành mặc dù đã có vắc xin phòng bệnh, bệnh nhân có biểu hiện lâm sàng điển hình và có nhiều biến chứng.
Xác định biến thể sars-cov-2 trên mẫu bệnh nhân Bắc Giang trong vụ dịch 2021 bằng công nghệ giải trình tự thế hệ mới
Authors: Hà Nguyễn Thị Hải , Tuấn Phạm Lê Anh , Tâm Nguyễn Thị , Lan Nguyễn Ngọc , Thắm Hoàng Hồng , Văn Tạ Thành , Khánh Trần Vân
Published: March 2023

Đại dịch của hội chứng viêm đường hô hấp cấp (COVID-19) do SARS-CoV-2 là mối đe dọa toàn cầu và đã gây ra những tổn thất nghiêm trọng về kinh tế và xã hội ở Việt Nam cũng như trên toàn thế giới. Việc xác định các biến thể SARS-CoV-2 đang lưu hành có ý nghĩa quan trọng trong việc theo dõi sự tiến hóa của virus, góp phần thúc đẩy nghiên cứu vắc xin và sinh phẩm chẩn đoán. Nghiên cứu này được thực hiện trên 38 bệnh nhân được chẩn đoán dương tính với SARS-CoV-2 từ khu công nghiệp tỉnh Bắc Giang với mục tiêu: Xác định biến thể SARS-CoV-2 và các biến đổi đặc thù trong bộ gen virus bằng phương pháp giải trình tự gen thế hệ mới (NGS). Độ tuổi trung bình tham gia nghiên cứu là 40,16 ± 14,07. Kết quả đã phát hiện được 38 mẫu virus SARS-CoV-2 thuộc biến chủng Delta, 16 biến đổi xuất hiện ở tất cả các mẫu bệnh phẩm, 27 biến đổi đặc thù chỉ xuất hiện ở một số mẫu trong đó có 3 biến đổi trên gen cấu trúc bao gồm S: Leu5Phe, Pro819Ser, His1101Tyr.
Sharing Health-Related Data and Buddhism
Authors: Voyce Malcolm
Published: March 2023

Health-related research funders, regulators and journals increasingly expect de-identified health research data to be shared widely. This article examines non-western reasons for decision-making in Thailand, a Buddhist country, to explore the extent to which Buddhist DACs should make decisions based on Buddhist norms. The method used in this study is a qualitative method with literature and sociology approaches. Meanwhile, the source of data came from the DAC and the perceptions of various Buddhists. The results of this study suggest that the social impact of big data on health has the support of Buddhists and the community so that there is data transparency that can be known by the wider community. In addition, health data is big data that can utilize technology in its management. In conclusion, data sharing raises concerns about the accuracy and reliability of data so that it needs supervision so that the data presented is the correct data.
Water footprint of ‘Gigante’ cactus pear with deficit irrigation using wastewater and blue water plus cattle manure
Authors: Souza José Alberto Alves de , Santos Delfran Batista dos , Donato Sérgio Luiz Rodrigues , Aspiazu Ignácio
Published: April 2023

This study aims to evaluate the water footprint of cactus pear cultivated under different irrigation strategies. Treatments were: no fertilization and no irrigation (T1); no fertilization and deficit irrigation (DI) with wastewater (0.6 L plant-1 week-1) (T2); no fertilization and DI with wastewater (1.2 L plant-1 week-1, once a week) (T3); no fertilization and DI with wastewater (1.2 L plant-1week-1, divided in two weekly applications) (T4); with organic fertilization (60 Mg ha-1 of bovine manure) and DI with blue water (1.2 L plant-1 week-1) (T5); and with organic fertilization (60 Mg ha-1 of bovine manure) and no irrigation (T6). Treatments were arranged in a completely randomized blocks design, with five replicates. Productivity, nutrients applied and consumption of green and blue water were evaluated. The water footprint was lower in treatments irrigated with wastewater than in the other treatments. The DI, using blue water, makes it possible to increase crop productivity without increasing water footprint; in the absence of irrigation, organic fertilization does not reduce the water footprint; the DI, using wastewater, makes it possible to increase crop productivity while decreasing water footprint.
Marketing Planning 4.0: Framework for Science and Technology Institutes
Authors: Almeida Mariana Inah de , Ferreira Cristiano , Pereira-Guizzo Camila
Published: April 2023

Interactions between Science and Technology Institutions (STIs) and the actors of the Innovation Ecosystem are essential to the technological development of businesses and society in a dynamic environment. In this situation, it is essential to integrate innovation and marketing strategies to improve the performance of STIs. There are numerous marketing methods and instruments currently available, but marketing 4.0 stands out. This study proposes a marketing 4.0 planning framework for STIs. To accomplish this, a preliminary systematic literature review and a survey of 14 STIs affiliated with EMBRAPII (Brazilian Enterprise for Research and Industrial Innovation) were conducted. The proposal for a marketing 4.0 planning framework for STIs is based on assumptions derived from a literature review and STIs' responses to a questionnaire. To shift strategic assumptions from the analog to the digital era, it is necessary to act on the consumer, competition, data, innovation, and value domains. Based on these presumptions, the framework consists of five stages: scenario comprehension, mapping/identification, planning/detail, action, and evaluation of results.
Growth and development of Paspalum virgatum L.
Authors: Labegalini Nayara Spricigo , Souza Felipe Henrique de , Mendes Kassio Ferreira , Inoue Miriam Hiroko , Figueiredo Adriana Matheus da Costa de , Guimarães Ana Carolina Dias
Published: March 2023

The objective of the work was to evaluate the growth and development of the razor-blade grass (Paspalum virgatum L.). The experimental design was a randomized complete block design with 17 treatments, and the growth evaluations were performed at 20, 27, 34, 41, 48, 55, 62, 69, 76, 83, 90, 97, 104, 111, 118, 125, 132 days after sowing (DAS) and five replications, considering as sowing date the day the seeds were placed in the plastic boxes. The evaluated characteristics were: total dry mass (Mt), shoot dry mass (Ma) and dry mass of roots (Mr), number of leaves and number of tillers per plant. The quantitative variables related to plant growth were analyzed by applying the F test on the analysis of variance followed by non-linear log-logistic regressions, with the objective of modeling the data in the form of equations. The razor-blade grass (Paspalum virgatum L.) is a weed with slow initial development and growth, but with high dry mass production at the end of the cycle.
Traditional knowledge: digital business model for transfer, licensing and availability
Authors: Rego Daniel Bandeira de Oliveira
Published: April 2023

The objective of this work is to present a technological conception of a digital platform for the transfer, licensing and availability of traditional knowledge of Brazilian peoples, in a fair and equitable way. For this, Design Science was used as a methodology, with the objective of systematically and iteratively approaching the proposition of the digital business model, among other aspects relevant to the success of the platform. As a theoretical basis, the main problems related to the lack of transparency in the sharing of benefits arising from the exploitation of traditional knowledge associated with biodiversity in Brazil, as well as the benefits that the transparent sharing of these benefits can bring to the communities that hold this knowledge. With the proposed platform, it is expected that innovation systems can have easy access to available traditional knowledge, while communities can be adequately remunerated for the exploration of their traditional knowledge and practices, generating jobs and income.
Collaborative teaching as a possibility to make the teaching of written portuguese as second language viable to the deaf
Authors: Pontes Alexson José Nunes , Daxenberger Ana Cristina Silva , Silveira Sergio Roberto
Published: April 2023

The objective of the research was to understand how the working model of collaborative teaching can help and make possible the teaching of written Portuguese as L2, corroborating the teaching and learning process of the Deaf. Considering that the Deaf student has the right to have a bilingual education and that he lives in a listening society, he will need the Portuguese language as an alternative for communication, therefore, we believe that collaborative teaching is important to guarantee the elimination of communication barriers and pedagogical. As this is a bibliographical research, primary and secondary sources were used, the main authors being scholars on education for the deaf and official documents. We found that when developing a collaborative teaching practice in the education of the deaf, the tendency is that the acquisition of the Portuguese language in the written modality can have better results, especially when it is associated with sign language.
"We are also land that populates”: the umbanda as a renegaded face of the brazilian cultural identity
Authors: Moura Virna , Figueirêdo Luciano , Gonçalves Yana , Aragão Janaína , Rocha Cristiana
Published: April 2023

This article is a study presented at the”1st Interdisciplinary Seminar on Society and Culture and deals about the Brazilian national identity through the prism of Umbanda religiosity, which we sought to present as an important face of the cultural identity built in Brazil from the 19th century onwards, despite being currently relegated to the condition of inferiority, mainly for displaying in its foundations practices related to Afro-Indian ethnicities that, in an unquestionable way, contributed substantially in the process of identity construction of Brazilian society. It is, therefore, a bibliographic research of a qualitative nature that, in the consultation of literature, scientific articles and numerical-documentary data, demonstrated the repetition of the myth of miscegenation in the present day regarding religious intolerance to the detriment of Umbanda practitioners.
IMPACT OF CULTURAL, MARKETING AND PRODUCT INNOVATIONS ON FIRMS PERFORMANCE OF SMEs
Authors: Khan Irfan Ahmad , Shar Amir Hussain , Junejo Mumtaz Ali
Published: April 2023

The purpose of this research is to analyze the connections between cultural innovation, product innovation and marketing innovation, with special focus on small and medium-sized businesses (SMEs). Sample population consisted of workers from several SMEs in Multan region of Pakistani manufacturing hub of Multan. Total of 291 SME’s workers and owners were used to compile this sample. To collect the information, we used a standardized questionnaire, the statistics package SPSS is useful for doing numerous statistical analyses on collected data (demographic analysis, correlation analysis & regression analysis). There is significant relationship between all the variables, and also regression analysis shows the model is fit and can predict research’s results. The study's findings can be used by managers at SMEs to develop the fresh approaches to product promotion. The results provide significant information for reaching decisions. Further, study provides the manager with a guide and set of actions for selling product credibly, that is essential for overcoming the problem of falling demand.
EXPLORING THE MODERATING ROLE OF TALENT MANAGEMENT AMID EMPLOYER BRANDING AND EMPLOYEES’ PERFORMANCE
Authors: Abbas Ghulam , Hussain Abid , Hassan Syed Ibnul
Published: April 2023

This research aims to determine how company brand influences employee performance. The second objective of this study is to examine that how talent management influences connection between employer brand and employee performance. The study's main data was collected using closed-ended and structured questions. Likert scales using 5-point Likert scale, spanning from 1 to 5, have been used to measure the response level. The statistical analysis of this research is based on random sample of 300 respondents who responded to a questionnaire. To test the expected associations between the research variables, the partial least squares (PLS) approach of structural equation modelling (SEM) was used. Researcher also analyzed the direct and indirect correlations between variables in the structural model. The data indicate that employer branding has a significant effect on employee performance. It is strong predictor of increased levels of performance & talent management moderates the association significantly and thus provide the clues to future researchers for further studies.
THE ROLE OF SPIRITUAL LEADERSHIP AND INCLUSION PRACTICES UPON WORKPLACE SPIRITUALITY
Authors: Akbar Umar , Arshad Muhammad , Abbas Khawar
Published: April 2023

The major objective of current research is to investigate the role of spiritual leadership and inclusion practices on workplace spirituality. The sample size of study consisted of manufacturing companies operating in selected cities of Pakistan. Sample selected for this study was 300 which was selected based on previous literature. 300 questionnaires were distributed among managers at a diverse levels of manufacturing companies. Research used probability-based, simple random selection plan to choose participants for questionnaire completion. The results suggested that spiritual leadership had a significant effect upon workplace spirituality. Results suggested that inclusion practices have significant effect on workplace spirituality. Study is vital for managers and companies’ policy makers to make policies by using study findings to boost productivity of employees. This research is restricted to examining how performance of MNC’s industry is affected by influence of just a few aspects of leadership. Comparison of influence of leadership in MNC’s and small and medium-sized enterprises would provide a new perspective to the study of literature and leadership.
dignidad humana desde una mirada Grecolatina
Authors: Barrera Gómez Carlos Enrique
Published: March 2023

Este artículo estudia algunos rasgos conceptuales de la dignidad humana en cuatro grandes pensadores del mundo grecolatino: Platón, Aristóteles, Cicerón y Séneca. A través de algunas de las principales obras de estos autores se exploran ciertas claves de dignidad y se considera el nivel de importancia que ostentan. Del mismo modo, el presente trabajo busca determinar a qué tipo de dignidad se refieren estos filósofos cuando hablan de la excelencia humana, cuáles son las principales fuentes de dignidad que advierten, así como algunos de los obstáculos que ellos atisban para el posible desarrollo de la dignidad humana.
Pemberdayaan Keluarga dalam Merawat Anak Balita dengan Pneumonia Pasca Hospitalisasi
Authors: Purwati Nyimas Heny , Natashia Dhea , Apriliawati Anita , Purnamawati Dewi , Wahyuni Emmy Putri , Imrotun Tri , Yuniarsih Yuniarsih
Published: April 2023

Background: Pneumonia is an acute respiratory infection that attacks the lungs. Pneumonia causes symptoms of difficulty breathing which if left untreated will lead to death. Families with problems with family members who experience illness or disease often make the family unable to meet health care needs or experience powerlessness which worsens the health condition of family members who experience health problems. Nursing intervention is needed to overcome the problem of family powerlessness.
Objectives: This community service aims to increase mothers' knowledge and perceptions of caring for toddlers with pneumonia after being hospitalized at Pasar Rebo Hospital.
Methods: The method used consists of identifying problems and needs, assessing problems, formulating plans, providing health education, and monitoring the ability of mothers to care for toddlers with pneumonia after being hospitalized. This community service was carried out for four months from June to September 2022. The health education activity was carried out for one day in the children's care room at Pasar Rebo Hospital. The target of this community service activity is mothers who have toddlers with pneumonia who are treated at Pasar Rebo Hospital as many as 10 people.
Results: The results of the evaluation show that the average value of knowledge is post-test> pre-test and the average value of attitude is post-test> pre-test.
Conclusion: There is an increase in the knowledge and attitude of mothers in caring for children under five with pneumonia after hospitalization. Health education needs to be carried out on an ongoing basis for mothers who have children under five with post-hospitalization pneumonia so they can carry out optimal care and prevent repeated treatments.
Fatores associados com ansiedade e depressão durante a pandemia de COVID-19 na população brasileira
Authors: De Souza Júnior Ricardo , Ferrari Landmann Alessandra , Da Silva Botezzini Giovanna , Laschewitz Wamser Johanna , Smaniotto Madeira Maria Eduarda
Published: April 2023

Introdução: Além do coronavírus, a pandemia de COVID-19 trouxe uma carga emocional e psicológica extensa para toda sociedade, a qual afetou diversos grupos sociais e faixas etárias. Dessa forma, este trabalho tem como objetivo realizar uma revisão integrativa acerca dos transtornos mentais e os fatores a eles associados no Brasil pandêmico. Metodologia: Para proceder com tal estudo, foi realizado uma pesquisa bibliográfica de artigos pertinentes ao tema nos bancos de dados “SciElo” e “Lilacs”, utilizando de descritores definidos de acordo com os Descritores em Ciências da Saúde (DeCS), sendo eles: “infecções por coronavírus”, “ansiedade”, “depressão”. Resultados: Após a seleção com base nos critérios de inclusão e exclusão, foram selecionados 11 artigos para essa revisão. Discussão: A análise crítica dos artigos evidenciou a fragilidade da saúde mental de uma grande gama de indivíduos, dentre eles se destacaram os profissionais de saúde e as mulheres. Houve também um significativo aumento no número de casos de depressão, ansiedade e problemas relacionados ao sono. A incerteza sobre o futuro e a ausência de uma cura para o vírus foram fatores que se associaram com essas mazelas. Consequentemente, altos níveis de estresse, medo e angústia são percebidos pela população em geral que, por muitas vezes, acaba não procurando auxílio. Diante disso, ilustrou-se que práticas como Yoga e Reiki podem ser grandes ferramentas para uma boa saúde mental. Conclusão: Pode-se argumentar que a situação de dubiedade e grande receio tornou a sociedade suscetível a alterações na rotina e desencadeou novos padrões negativos na vida das pessoas, ameaçando seu bem-estar de várias maneiras. Para tanto, são necessárias ações que os motivem a buscar medidas, como a atividade física e até mesmo o tratamento terapêutico, visando o progresso e a consistência do estado de saúde mental.
The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases
Authors: Dong Peihua , Huang Yu , Pu Yujie
Published: April 2023

Review
The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Peihua Dong , Yu Huang , and Yujie Pu ,*

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China
* Correspondence: yujiepu@cityu.edu.hk
 
 
Received: 29 December 2022
Accepted: 18 January 2023
Published: 10 February 2023
 

Abstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.
Biological Functions and Applications of Exosomes in Drug Research
Authors: Fu Mengmeng , Li Jiapeng , Battulga Tungalag , Li Xiaoxue , Xu Ming
Published: April 2023

Review
Biological Functions and Applications of Exosomes in Drug Research

Mengmeng Fu 1, Jiapeng Li 1, Tungalag Battulga 2, Xiaoxue Li 3, *, and Ming Xu 1, *

1 Department of Clinical Pharmacy, School of Preclinical Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tong jia Lane, Nanjing 210009, China.
2 School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar-24210, Mongolia.
3 Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
* Correspondence: lxx84112@163.com(Xiaoxue Li); mingxu@cpu.edu.cn; Tel.: 025-86185653(Ming Xu)
 
 
Received: 9 October 2022
Accepted: 12 November 2022
Published: 11 January 2023
 

Abstract: Exosomes have received increasing attention in recent years as an important substance for intercellular communication. Among the plethora of new research is their unique interaction with drugs is even more striking. Exosomes play essential roles in disease treatment either as extracellular vesicles to exert biological functions or as drug carriers to deliver therapeutic agents. We summarized the relationship between exosomes and drugs in the disease progression and treatment. Understanding how exosomes interact with drugs and exert their anti-inflammatory and pro-angiogenic effects, alongside a lipid peroxidation inhibitory result in different manners is essential for disease treatment.
Strongly Pseudo Nearly_2_Absorbing Submosules
Authors: Aldoori Mohmad E. Dahash , Haibat K. Mohammadali
Published: March 2023

In this work we study a notion of strongly Pseudo Nearly 2-Absorbing submodule and some eneralization, it is a generalization of 2 Absorbing submodules, and a strong form of (Nearly 2 Absorbing and Pseudo 2 A bsorbing) submodule. Characterization and examples of the suggestion a generalization are given, as well as many different suggestion properties that have been roven.
The Self-Learning AI Controller for Adaptive Power Beaming With Fiber-Array Laser Transmitter System
Authors: Vorontsov A.M. , Filimonov G.A.
Published: March 2023

In this study we consider adaptive power beaming with a fiber-array laser transmitter system in presence of atmospheric turbulence. For optimization of power transition through the atmosphere a fiber-array is traditionally controlled by stochastic parallel gradient descent (SPGD) algorithm where control feedback is provided via a radio frequency link by an optical-to-electrical power conversion sensor, attached to a cooperative target. The SPGD algorithm continuously and randomly perturbs voltages applied to fiber-array phase shifters and fiber tip positioners in order to maximize sensor signal, i.e. uses, the so-called, “blind” optimization principle. By contrast to this approach a prospective artificially intelligent (AI) control systems for synthesis of optimal control can utilize various pupil- or target-plane data available for the analysis including wavefront sensor data, photo-voltaic array (PVA) data, other optical or atmospheric parameters, and potentially can eliminate well-known drawbacks of SPGDbased controllers. In this study an optimal control is synthesized by a deep neural network (DNN) using target-plane PVA sensor data as its input. A DNN training is occurred online in sync with control system operation and is performed by applying of small perturbations to DNN’s outputs. This approach does not require initial DNN’s pre-training as well as guarantees optimization of system performance in time. All theoretical results are verified by numerical experiments.
Kompetensi Profesional Guru PAI dalam Mengelola Sumber Belajar
Authors: Permata Sari Devi , Neliwati Neliwati , Telaumbanua Imam Ismail , Mulyani Nining
Published: April 2023

Penelitian ini bertujuan untuk mengetahui tentang kompetensi profesional guru PAI dalam mengelola sumber belajar yang ada disekolah SMP Negeri 5 Binjai untuk memperlancar aktifitas pembelajaran pendidikan agama islam (PAI). Adapun pendekatan penelitian yang digunakan yaitu penelitian kualitatif dengan metode studi deskriptif. Hasil penelitian ini menunjukkan bahwa pembelajaran PAI yang berlangsung di SMP Negeri 5 Binjai berjalan dengan baik. Meskipun sumber belajar yang ada di SMP Negeri 5 Binjai masih minim, namun dengan sumber belajar yang ada ini menjadi tantangan untuk guru yang mengajar di SMP tersebut untuk lebih kreatif dalam mengelola sumber belajar yang ada agar tidak terkesan monoton. Untuk kendala-kendala yang dialami oleh pendidik dalam mengelola sumber belajar dapat diatasi jika berbagai pihak dapat melakukan kerja sama yang baik, baik itu pendidik, peserta didik ataupun kepala sekolah untuk terus meningkatkan kebutuhan warga sekolah agar meningkatkan mutu pembelajaran.
Penilaian Autentik Kurikulum 2013 pada Pembelajaran Al-Qur’an Hadits Kelas IX MTs Alwashliyah Tanjung Mulia Medan
Authors: Neliwati Neliwati , Hidayah Taufiq , Nasution Melati Maharani , Hasibuan Nur Asiah
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan penilaian autentik kurikulum 2013 pada pembelajaran Al-Qur’an Hadits di MTs Tanjung Mulia Medan. Penelitian ini menggunakan penelitian kualitatif dengan metode study deskriptif. Pemerolehan data dilakukan dengan teknik observasi, wawancara, dan dokumentasi. Dan selanjutnya dilakukan teknik reduksi data, penyajian data dan penarikan kesimpulan sebagai upaya hasil analisis data. Hasil dari penelitian ini menemukan bahwa Pelaksanaan penilaian autentik kurikulum 2013 pada pembelajaran al-qur’an hadits belum dapat berjalan secara maksimal dikarenakan masih terdapat kesulitan pendidik dalam aspek penilaian sikap dari peserta didik yang kurang sesuai antara nilai akademiknya dengan sikap atau akhlak dari peserta didik tersebut.
Pengembangan Media Ajar Bahasa Indonesia Berbentuk Audio Visual Berupa Wayang
Authors: Zamnoor Putria Shalsha Ayu , Afifah Sindi Zahirotul , Rosalina Sinta
Published: April 2023

Media pembelajaran adalah perantara yang digunakan untuk menyampaikan materi ke pelajar dengan menggunakan alat tertentu agar pelajar dapat mengerti dengan cepat dan menerima pengetahuan dari pengajar. Menurut Suprijanto (2009) menyatakan bahwa  media  audio  visual  adalah  bahan  atau  alat yang  dipergunakan dalam  situasi  belajar  untuk  membantu  tulisan  dan  kata  yang  diucapkan  dalam menularkan  pengetahuan, sikap dan ide. Tujuan dari penelitian ini adalah untuk menghasilkan   produk pengembangan media pembelajaran audio visual (teks, gambar, video,  gerak)  dan alat peraga berupa wayang berbahan bekas pada materi Teks Naratif dalam cerpen di kelas XI dalam meningkatkan pemahaman konsep serta dapat dijadikan sebagai media atau sumber belajar bagi siswa.
Pengaruh Tingkat Pendidikan dan Pengalaman Kerja terhadap Etos Kerja Karyawan
Authors: Riani Silva Okta , Putra Ivan Gumilar Sambas
Published: April 2023

Sumber daya manusia (SDM) ialah faktor yang sangat berarti untuk memastikan keberhasilan perusahaan, sebab manusia ialah suatu makhluk yang memiliki pikiran, kebutuhan, perasaan,  serta harapan tertentu. Di dalam sebuah perusahaan biasanya terdapat karyawan dengan latar belakang tingkat pendidikan yang berlainan dan pengetahuan yang berlainan, baik yang baru memulai dunia kerja ataupun  yang telah berpengalaman kerja sebelumnya. Tujuan dari riset ini adalah dalam menelusuri pengaruh pengalaman kerja dan tingkat pendidikan pada etos kerja pegawai. Riset ini mempergunakan metode kuantitatif. Pada riset ini populasinya ialah semua pegawai PT. Nikkatsu Elektrik Works yang berjumlah 295 orang. Sampel pada riset ini dihitung dengan mempergunakan persamaan slovin dan hasilnya dengan jumlah 170 responden. Pengumpulan data mempergunakan kuesioner dan terlebih dahulu dilaksanakan uji coba reliabilitas dan validitas, pengujian asumsi klasik yang melingkupi pengujian normalitas, pengujian multikolinearitas, pengujian heterokedastisitas serta dilanjutkan dengan uji linearitas berganda, uji model F, koefisien determinasi dan uji hipotesis (Uji T) dengan bantuan software IBM SPSS. Temuan dari riset memperlihatkan bahwa tingkat pendidikan tidak mempengaruhi signifikan pada etos kerja dan pengalaman kerja mempengaruhi pada etos kerja.
Pengaruh Tenaga Kerja Honorer terhadap Kinerja ASN pada Kantor Kecamatan Rancasari
Authors: Sukandi Pipin , Al’aziz Muhammad Ramadhan
Published: April 2023

Kantor kecamatan Rancasari berada di Jalan Santosa Asih No. 17 Kelurahan Cipamokolan Kecamatan Rancasari Kota Bandung, dengan jumlah keseluruhan SKPD kecamatan rancasari sebanyak 96 pegawai. Terdiri dari tenaga kerja honorer 43 orang dan pegawai ASN 53 orang. Tenaga kerja honorer adalah seorang yang diangkat oleh pejabat Pembina kepegawaian dalam pemerintahan untuk melaksanakan tugas pada instansi pemerintahan menjadi beban anggaran pendapatan negara, Tenaga kerja honorer merupakan pegawai yang bekerja pada pemerintahan yang bersifat honorium, dalam beberapa literatur menjabarkan tenaga kerja honorer mempunyai tugas yang bersifat teknis professional dan administrasi dengan kebutuhan serta kemampuan organisasi. Pegawai ASN merupakan aparatur sipil negara yang diangkat oleh pemerintah dengan status sebagai pegawai tetap, ASN akan mendapatkan gaji, tunjangan dan jaminan hari tua. ASN juga sebagai perencana, pelaksana dan pengawas penyelenggaraan tugas umum pemerintahan dan pembangunan nasional melalui kebijakan dan pelayanan publik. Kemudian peneliti ingin mengetahui bagaimana pengaruh tenaga kerja honorer terhadap kinerja ASN di kecamatan rancasari kota bandung dengan dilakukannya penelitian ini. Dalam penelitian ini metode yang digunakan merupakan metodee kuantitatif deskriptif dengan Teknik analisis data uji reliabilitas, Uji validitas, Analisis Regresi Linear Sedderhana, dan Uji Asumsi Klasik. Sehingga ditemukan hasil dari penelitian ini bahwa sebesar 15,2% tenaga kerja honorer mempengaruhi pegawai ASN pada kantor kecamatan rancasari Kota Bandung.
Kelautan Indonesia Mempengaruhi Kerja Sama Bilateral Negara-Negara Tetangga untuk Menyelesaikan Masalah di Perairan Indonesia
Authors: Haris Moch , Feriyanti Nentin
Published: April 2023

Pada tanggal 17 Agustus 1945, Ketika Indonesia merdeka, tidak diketahui berapa luas wilayah negara ini Sampai Akhirnya, pada tahun 1949, Konferensi Meja Bundar (KMB) diselenggarakan di Belanda Informasi tentang wilayah Indonesia Wilayah Indonesia diperluas 5.110 kilometer dari barat ke timur dan dari utara ke selatan 1.888 km2, luas  5.193.252 km2, dimana 1.890.754 km2 di pedesaan dan 3.302.498 km2 di pedesaan laut Sehingga Indonesia disebut negara Lautan atau Negeri Lautan. Oleh karena itu cocok untuk Indonesia tertarik pada pemantauan dan eksploitasi laut. namun   Padahal, potensi sektor perkapalan belum tergarap secara maksimal. Oleh karena itu, pemerintah Republik Indonesia berusaha untuk membuat suatu kebijakan Pelayaran bertujuan untuk kesejahteraan rakyat.