bluuebunny/crossref_metadata_2025 huggingface dataset:
Iodine knowledge is positively associated with dietary iodine intake among women of childbearing age in the UK and Ireland
Authors: O’Kane S. Maria , Pourshahidi L. Kirsty , Farren Kayla M. , Mulhern Maria S. , Strain J. J. , Yeates Alison J.
Published: November 2016

Adequate I intake is important before conception and during pregnancy for optimal infant neurodevelopment. Recent studies have highlighted the prevalence of I deficiency in the UK and Ireland. It is possible that optimal I intake may be impeded by a poor knowledge of I nutrition. This study aimed to investigate I knowledge among women of childbearing age in the UK and Ireland and to determine whether a relationship exists between I knowledge and dietary I intake. Females (aged 18–45 years) were invited to complete an online questionnaire, which assessed knowledge of I and estimated dietary I intake using a FFQ. A total of 520 females of childbearing age completed the study. I knowledge was poor; only one-third (32 %) of the participants correctly identified pregnancy as the most important stage of the lifecycle for I, and 41 % of participants could not correctly identify any health problem related to I deficiency. The median daily I intake was estimated as 152 µg/d. Almost half (46 %) of the participants failed to meet dietary recommendations (140 µg/d) for I. A higher dietary I intake was positively associated with greater I knowledge (r 0·107; P=0·016). This study suggests that knowledge of I nutrition is low among women of childbearing age, and those with a greater knowledge of I nutrition had a higher dietary I intake. Initiatives to educate women of childbearing age on the importance of I nutrition should be considered as part of a larger public health strategy to address I deficiency.
THE REPUBLIC OF THE REFUGEES: EARLY MODERN MIGRATIONS AND THE DUTCH EXPERIENCE
Authors: JANSSEN GEERT H.
Published: November 2016

This essay surveys the wave of new literature on early modern migration and assesses its impact on the Dutch golden age. From the late sixteenth century, the Netherlands developed into an international hub of religious refugees, displaced minorities, and labour migrants. While migration to the Dutch Republic has often been studied in socio-economic terms, recent historiography has turned the focus of attention to its many cultural resonances. More specifically, it has been noted that the arrival of thousands of newcomers generated the construction of new patriotic narratives and cultural codes in Dutch society. The experience of civil war and forced migration during the Dutch revolt had already fostered the development of a national discourse that framed religious exile as a heroic experience. In the seventeenth century, the accommodation of persecuted minorities could therefore be presented as something typically ‘Dutch’. It followed that diaspora identities and signs of transnational religious solidarity developed into markers of social respectability and tools of cultural integration. The notion of a ‘republic of the refugees’ had profound international implications, too, because it shaped and justified Dutch interventions abroad.
Helminth parasites of South American fishes: current status and characterization as a model for studies of biodiversity
Authors: Luque J.L. , Pereira F.B. , Alves P.V. , Oliva M.E. , Timi J.T.
Published: November 2016

The South American subcontinent supports one of the world's most diverse and commercially very important ichthyofauna. In this context, the study of South American fish parasites is of increased relevance in understanding their key roles in ecosystems, regulating the abundance or density of host populations, stabilizing food webs and structuring host communities. It is hard to estimate the number of fish parasites in South America. The number of fish species studied for parasites is still low (less than 10%), although the total number of host–parasite associations (HPAs) found in the present study was 3971. Monogeneans, with 835 species (1123 HPAs, 28.5%), and trematodes, with 662 species (1127 HPAs, 30.9%), are the more diverse groups. Data gathered from the literature are useful to roughly estimate species richness of helminths from South American fish, even though there are some associated problems: the reliability of information depends on accurate species identification; the lack of knowledge about life cycles; the increasing number of discoveries of cryptic species and the geographically biased number of studies. Therefore, the closest true estimations of species diversity and distribution will rely on further studies combining both molecular and morphological approaches with ecological data such as host specificity, geographical distribution and life-cycle data. Research on biodiversity of fish parasites in South America is influenced by problems such as funding, taxonomic impediments and dispersion of research groups. Increasing collaboration, interchange and research networks in the context of globalization will enable a promising future for fish parasitology in South America.
Biodiversity offsetting and the reframing of conservation: a reply to ten Kate & von Hase and Dempsey & Collard
Authors: Apostolopoulou Evangelia , Adams William M.
Published: November 2016

We are grateful to ten Kate & von Hase (2016) and Dempsey & Collard (2016) for their insightful and constructive responses to our article on biodiversity offsetting (Apostolopoulou & Adams, 2015a). They agree with us that conservationists need to think very carefully about offsetting and its implications for nature conservation. They differ substantially in where that thinking should lead. Ten Kate & von Hase believe that offsetting is fine if it is done properly. Dempsey & Collard are profoundly uneasy about its implications, and go deeper into the way conservation is folded into economic development, ‘smoothing the way for new industrial scale projects’.
Cross-reactivity of the 31 kDa antigen of Angiostrongylus cantonensis – Dealing with the immunodiagnosis of meningoencephalitis
Authors: MORASSUTTI ALESSANDRA L. , RASCOE LISA N. , HANDALI SUKWAN , DA SILVA ALEXANDRE J. , WILKINS PATRICIA P. , GRAEFF-TEIXEIRA CARLOS
Published: November 2016

The primary causative agent of eosinophilic meningoencephalitis (EoM) in endemic regions is the nematode Angiostrongylus cantonensis. The occurrence of EoM was previously restricted to countries in Southeast Asia and the Pacific Islands; however, more recently, it has been reported from other regions, including Brazil. The commonly used diagnosis is detection of specific antibody reactivity to the 31 kDa antigen, which is derived from female worm somatic extracts. Here we report the occurrence of cross-reactivity to this antigen in sera from other parasitic infections, especially those that may cause EoM, such as gnathostomiasis, toxocariasis, hydatidosis and strongyloidiasis. We also demonstrated that the cross-reactivity, in part, is dependent of the concentration of antigen used in Western blot assays. We discuss the importance of these findings on the interpretation of this test.
Life satisfaction of migrants, stayers and returnees: reaping the fruits of migration in old age?
Authors: BAYKARA-KRUMME HELEN , PLATT LUCINDA
Published: November 2016

This paper evaluates the effects of migration on life satisfaction in later life. We compare the life satisfaction of older migrants with that of non-migrants and return migrants of a similar age and originating from the same regions in Turkey. Turks constitute one of the largest migrant groups in Europe, and the growing population of older Turkish migrants display greater risks of loneliness and material disadvantage compared to native-born populations in Europe. However, compared to their non-migrant peers from the country of origin, older migrants may experience gains from migration that are reflected in their life satisfaction. Using the 2000 Families Study, a large survey of Turkish migrants from the peak labour migration period and their non-migrant comparators, we investigate whether life satisfaction of migrants and stayers differs and the possible causes of any differences. We find that both migrants and return migrants experience higher life satisfaction in old age than stayers. However, the gap cannot be explained by the classical determinants of life satisfaction such as income, health, partner and friends, or religiosity, nor by the better outcomes of the migrants’ children. We discuss possible reasons for this migration satisfaction advantage.
Dynamic intertextuality in the Miracula Nynie episcopi: remembering Arator's Historia apostolica
Authors: Hillier Richard
Published: November 2016

It has long been acknowledged that Arator, author of the sixth-century Historia apostolica, was one of the Christian Latin writers with whom the author of the eighth-century Miracula Nynie episcopi was familiar. However, until now the critical consensus has been that the later poem was little more than a ‘cut-and-paste’ pastiche: Arator's phrases had been chosen largely for their metrical suitability; some were perhaps just ‘recycled’ borrowings rather than evidence of first-hand reading. But a close comparison of the two texts shows that the extent of the unknown author's borrowings from Arator is far greater than has hitherto been realized. Furthermore it reveals a detailed knowledge of the earlier poem, indeed an intimate understanding of it. This is evident not only in his poetic diction but also in his imitation of specific narrative detail where he displays a tendency to simplify his model, rendering the abstract concrete and the figurative literal.
A new Agnus Dei/Last Small Cross mule
Authors: Keynes Simon , Naismith Rory
Published: November 2016

The Lenborough hoard has produced the twenty-third coin struck from Agnus Dei dies, which is also the second known mule of an Agnus Dei obverse with a Last Small Cross reverse. It is illustrated in Gareth Williams's preceding article as Fig. 7 (p. 304). This specimen adds to the small group of English finds of Agnus Dei pennies, which previously consisted of three single-finds. Lenborough is therefore the first ever English hoard to contain an Agnus Dei coin, mule or otherwise. The presence of just one penny of the type in an assemblage of almost 1,000 coins of Æthelred II (with a large proportion of the total consisting of the types either side of Agnus Dei) reinforces the rarity of the issue. Detailed research into the hoard may unveil more about the circumstances behind its composition, including the chronological profile of the Last Small Cross element, and thereby add to the general picture of the context in which Agnus Dei was produced.
Analysis of Ephemeris Errors in Autonomous Celestial Navigation during Mars Approach Phase
Authors: Ning Xiaolin , Li Zhuo , Yang Yuqing , Fang Jiancheng , Liu Gang
Published: November 2016

A Celestial Navigation System (CNS) is a feasible and economical autonomous navigation system for deep-space probes. Ephemeris errors have a great influence on the performance of CNSs during the Mars approach phase, but there are few research studies on this problem. In this paper, the analysis shows that the ephemeris error of Mars is slowly-varying, while the ephemeris error of Phobos and Deimos is periodical. The influence of the ephemeris errors of Mars and its satellites is analysed in relation to both the Sun-centred frame and the Mars-centred frame. The simulations show that the position error of a probe relative to the Sun caused by the Mars ephemeris error is almost equal to the ephemeris error itself, that the velocity error is affected slightly, and that the position and velocity relative to Mars are hardly affected. The navigation result of a Mars probe is also greatly affected by the quantities and periodicities of the ephemeris errors of Phobos and Deimos, especially that of Deimos.
Exploring genotype concordance in epidemiologically linked cases of tuberculosis in New York City
Authors: ROBBINS R. S. , PERRI B. R. , AHUJA S. D. , ANGER H. A. , SULLIVAN MEISSNER J. , SHASHKINA E. , KREISWIRTH B. N. , PROOPS D. C.
Published: November 2016

Comparing genotype results of tuberculosis (TB) isolates from individuals diagnosed with TB can support or refute transmission; however, these conclusions are based upon the criteria used to define a genotype match. We used a genotype-match definition which allowed for variation in IS6110restriction fragment length polymorphism (RFLP) to support transmission between epidemiologically linked persons. Contacts of individuals with infectious TB (index cases) diagnosed in New York City from 1997 to 2003 who subsequently developed TB (contact cases) from 1997 to 2007 were identified. For each contact case and index case (case-pair), isolate genotypes (spoligotype and RFLP results) were evaluated. Isolates from case-pairs were classified as exact or non-exact genotype match. Genotypes from non-exact match case-pairs were reviewed at the genotyping laboratory to determine if the isolates met the near-genotype-match criteria (exactly matching spoligotype and similar RFLP banding patterns). Of 118 case-pairs identified, isolates from 83 (70%) had exactly matching genotypes and 14 (12%) had nearly matching genotypes (supporting transmission), while the remaining 21 (18%) case-pairs had discordant genotypes (refuting transmission). Using identical genotype-match criteria for isolates from case-pairs epidemiologically linked through contact investigation may lead to underestimation of transmission. TB programmes should consider the value of expanding genotype-match criteria to more accurately assess transmission between such cases.
Predictive modelling of Ross River virus notifications in southeastern Australia
Authors: CUTCHER Z. , WILLIAMSON E. , LYNCH S. E. , ROWE S. , CLOTHIER H. J. , FIRESTONE S. M.
Published: November 2016

Ross River virus (RRV) is a mosquito-borne virus endemic to Australia. The disease, marked by arthritis, myalgia and rash, has a complex epidemiology involving several mosquito species and wildlife reservoirs. Outbreak years coincide with climatic conditions conducive to mosquito population growth. We developed regression models for human RRV notifications in the Mildura Local Government Area, Victoria, Australia with the objective of increasing understanding of the relationships in this complex system, providing trigger points for intervention and developing a forecast model. Surveillance, climatic, environmental and entomological data for the period July 2000–June 2011 were used for model training then forecasts were validated for July 2011–June 2015. Rainfall and vapour pressure were the key factors for forecasting RRV notifications. Validation of models showed they predicted RRV counts with an accuracy of 81%. Two major RRV mosquito vectors (Culex annulirostris and Aedes camptorhynchus) were important in the final estimation model at proximal lags. The findings of this analysis advance understanding of the drivers of RRV in temperate climatic zones and the models will inform public health agencies of periods of increased risk.
Tuberculosis infection testing in HIV-positive men who have sex with men from Xi'an China
Authors: XIN H. N. , LI X. W. , ZHANG L. , LI Z. , ZHANG H. R. , YANG Y. , LI M. F. , FENG B. X. , LI H. J. , GAO L.
Published: November 2016

In individuals with latent tuberculosis (TB) infection, those living with human immunodeficiency virus (HIV) had a 20–37 times higher risk of developing active TB compared to those without HIV infection. Systematic testing and treatment of latent TB infection are priorities in HIV-infected persons. In China, the prevalence of HIV infection in men who have sex with men (MSM) has gradually increased in the past decade. However, the prevalence of TB infection has been studied sparsely in HIV-infected MSM. Hence, we conducted a pilot study in MSM living with HIV infection in Xi'an city to evaluate TB infection status by means of interferon-γrelease assay (IGRA). A total of 182 HIV-infected MSM were included in this study, the prevalence of IGRA positivity was observed to be 8·79% (16/182). IGRA quantitative results were not statistically influenced by the CD4 cell counts of the study participants. However, IGRA positivity was found to be lower than our previously reported data from the general population. This suggests that immunological deficiency might decrease the sensitivity of IGRA and thus increase the number of false negatives. Our primary results, suggesting systematic testing and treatment of latent TB infection together with active case-finding, were equally important for TB control in persons living with HIV infection.
Dietary DHA and health: cognitive function ageing
Authors: Cardoso Carlos , Afonso Cláudia , Bandarra Narcisa M.
Published: November 2016

DHA is a key nutritionaln-3 PUFA and needs to be supplied by the human diet. DHA is found in significant amounts in the retinal and neuronal cell membranes due to its high fluidity. Indeed, DHA is selectively concentrated in the synaptic and retinal membranes. DHA is deemed to display anti-inflammatory properties and to reduce the risk of CVD. Consumption of larger amounts of DHA appears to reduce the risk of depression, bipolar disorder, schizophrenia and mood disorders. Conversely, it has been shown that loss of DHA from the nerve cell membrane leads to dysfunction of the central nervous system in the form of anxiety, irritability, susceptibility to stress, dyslexia, impaired memory and cognitive functions, and extended reaction times. DHA plays an important role in ensuring a healthy ageing, by thwarting macular degeneration, Alzheimer’s disease, and other brain disorders at the same time as enhancing memory and strengthening neuroprotection in general. A reduced level of DHA is associated with cognitive decline during ageing. Different mechanisms for this fundamental DHA role have been put forward. Namely, neuroprotectin D1, a DHA derivative, may support brain cell survival and repair through neurotrophic, anti-apoptotic, and anti-inflammatory signalling. Many of the effects of DHA on the neurological system may be related to signalling connections, thus leading to the study of the related signalolipidomics. Therefore, the present review will focus on the influence of DHA deficiency upon ageing, with specific emphasis upon neurological disorders related to cognitive function and mental health.
Exclusion of overlapping symptoms in DSM-5 mixed features specifier: heuristic diagnostic and treatment implications
Authors: Malhi Gin S , Byrow Yulisha , Outhred Tim , Fritz Kristina
Published: November 2016

This article focuses on the controversial decision to exclude the overlapping symptoms of distractibility, irritability, and psychomotor agitation (DIP) with the introduction of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) mixed features specifier. In order to understand the placement of mixed states within the current classification system, we first review the evolution of mixed states. Then, using Kraepelin’s original classification of mixed states, we compare and contrast his conceptualization with modern day definitions. The DSM-5 workgroup excluded DIP symptoms, arguing that they lack the ability to differentiate between manic and depressive states; however, accumulating evidence suggests that DIP symptoms may be core features of mixed states. We suggest a return to a Kraepelinian approach to classification—with mood, ideation, and activity as key axes—and reintegration of DIP symptoms as features that are expressed across presentations. An inclusive definition of mixed states is urgently needed to resolve confusion in clinical practice and to redirect future research efforts.
LEGAL POWERS IN PRIVATE LAW
Authors: Essert Christopher
Published: November 2016

This article explores the nature and role of legal powers in private law. I show how powers are special in that they allow agents to change their (and others’) legal circumstances merely by communicating an intention to do so, without having also to change the nonnormative facts of the world. This feature of powers is, I argue, particularly salient in private law, with its correlative or bipolar normative structure; understanding powers and their role in private law thus requires careful attention to this correlativity. In the final section, I argue that the correct explanation of a variety of substantive problems in private law, many having to do with the role of a party's intention, turns on correctly understanding legal powers.
Latino mothers’ beliefs about child weight and family health
Authors: Martinez Suzanna M , Rhee Kyung E , Blanco Estela , Boutelle Kerri
Published: November 2016

Objective

There is a need to address cultural beliefs and parenting practices regarding childhood obesity to design effective weight-control programmes for overweight/obese US Latino children. The purpose of the current study was to explore cultural beliefs about children’s weight, understand parent perceptions on feeding their children, and explore barriers that interfere with a healthy lifestyle.

Design

Four focus groups were conducted in Spanish with forty-one Latino mothers of elementary school-age children from San Diego County, California between April and May 2011. Cultural viewpoints about overweight status among children and barriers to leading a healthy lifestyle were explored. Focus group discussions were analysed based ona prioriand emergent themes.

Results

Three themes were identified: (i) mothers’ cultural beliefs about health that are barriers to family health; (ii) mothers as primary caretakers of their family’s health; and (iii) attitudes about targeting children’s weight. Mothers acknowledged the idea that ‘chubby is better’ is a misperception, yet having a ‘chubby’ child was preferred and even accepted. Mothers described fatalistic beliefs that contradicted existing knowledge of chronic disease and daily demands of Western culture as barriers to practising healthy behaviours in the home as the family caretaker.

Conclusions

These findings may be used to inform more culturally appropriate research to address US Latino health. Increasing awareness of cultural beliefs and daily circumstance could help to address obesity more directly and thereby overcome some of the potential underlying barriers that might exist when involving the Latino immigrant families in obesity treatment and prevention.
A miniature tri-band RFID reader antenna with high gain for portable devices
Authors: Wang Bo , Wang Wenqing
Published: November 2016

This paper presents a miniature monopole reader antenna for tri-band radio frequency identification (RFID) portable devices. The proposed antenna operates at the main RFID frequencies and can alleviate and compensate for the shortcomings of a single-band antenna. An additional rectangular stub couples with the bent monopole antenna, allowing the latter to resonate at the RFID bands at 902–928 MHz, 2.4–2.48 GHz, and 5.725–5.875 GHz. By bending the feedline, the dimensions of the miniature antenna are reduced to 115.5 × 20 × 1.6 mm3, facilitating its integration into portable devices. The measured bandwidths(return loss < −10 dB) of the proposed antenna are 677, 580, and 250 MHz in the three operating bands, 883–1560 MHz, 2.31–2.89 GHz, and 5.65–5.9 GHz, respectively, with high-gain characteristics. An experimental study of a fabricated prototype of the optimized antenna is performed, and the results verify its good performance.
New directions for psychiatric rehabilitation in the USA
Authors: Bond G. R. , Drake R. E.
Published: November 2016

American researchers have led the world in developing, evaluating, and disseminating evidence-based psychiatric rehabilitation practices for people with serious mental illness. Paradoxically, however, the USA lags behind most industrialized nations in providing access to high-quality mental health and psychiatric services. This essay examines several evidence-based practices developed in the USA, the spread of these practices, the barriers to ensuring availability to people who could benefit from these services, and some promising directions for overcoming the barriers. Factors influencing the growth and sustainment of effective client-centred practices include the availability of adequate and stable funding, committed leadership, and the influence of vested interests. Two strategies for promoting the spread and sustainment of well-implemented evidence-based practices are the adoption of fidelity scales and learning communities.
Preventive Effect of Carvacrol Against Oxidative Damage in Aged Rat Liver
Authors: Samarghandian Saeed , Azimi-Nezhad Mohsen , Farkhondeh Tahereh
Published: November 2016

Abstract. The present study was designed to investigate the changes in activities of antioxidant enzymes and lipid peroxidation level in the liver of 2, 10 and 20 months old rats, and to see whether these changes are restored to those of the two month old rats after carvacrol treatment. Male rats of 2, 10, and 20 months (n = 10 for each group) were used for all the experiments. The aged rats (10 and 20 months old) were given carvacrol (15 mg/day per body weight) for 30 days. Control animals received an equal volume of vehicle. After the treatment, livers were removed for estimation of superoxide dismutase-SOD, glutathione-S-transferase-GST, catalase-CAT activities and lipid peroxidation level. The present findings determined that normal aging was associated with a significant decrease in the activities of antioxidant enzymes (SOD; 11.87 ± 0.6 (2 months old) vs 7.56 ± 0.1 (20 months old); P < 0.001) in liver, as well as an increase in lipid peroxidation level (MDA; 0.15 ± 0.01 (2 months old) vs 0.41 ± 0.01 (20 months old); P < 0.001) in aged rats. Also, the results of this study indicated that carvacrol treatment increased the activities of the antioxidant enzymes in 20 months old animals versus the aged matched control group (SOD; 9.87 ± 0.4; P < 0.01). Furthermore, carvacrol decreased lipid peroxidation content in 10 and 20 months old animals compared with the aged matched control (MDA; 9.87 ± 0.4; P < 0.001). Our data shows that carvacrol could be a candidate to inhibit the development of age-induced liver damage through inhibition of oxidative stress and also increasing antioxidant defenses.
Carotid artery stenting with double cerebral embolic protection in asymptomatic patients – a diffusion-weighted MRI controlled study
Authors: Vuruskan Ertan , Saracoglu Erhan , Ergun Ugur , Poyraz Fatih , Duzen İrfan Veysel
Published: November 2016

Abstract. Background: The aim of this study was to compare the simultaneous double-protection method (proximal balloon plus distal filter) with distal-filter protection or proximal-balloon protection alone in asymptomatic patients during carotid artery stenting. Patients and methods: 119 consecutive patients were investigated for carotid artery stentings in the extracranial internal carotid artery with the use of distal filters (n = 41, 34.4 %), proximal balloon (MoMa) protection (n = 40, 33.6 %) or double protection (n = 38, 31.9 %). Magnetic resonance imaging (MRI) was performed on all patients before the procedure, and control diffusion-weighted MRI (DW-MRI) was obtained within 24–48 h after the procedure. Procedural data, complications, success rate, major adverse cardiovascular events, and MRI findings were collected. Results: New cerebral high-intensity (HI) lesions were observed in 47 (39.4 %) patients. HI lesions were observed in 22 (53.6 %), 15 (37.5 %), and 10 (26.3 %) of the patients with distal filters, proximal protection, and double protection, respectively (p = 0.004). The average number of HI lesions on DW-MRI was 1.80 in the distal-filter group, 0.90 in the proximal-balloon group, and 0.55 in the double-protection group (p < 0.001). Procedure and fluoroscopy times were slightly longer in the double-protection group compared to the distal- or proximal-protection groups (p = 0.001). Conclusions: The double (proximal plus distal) cerebral embolic protection technique is safe and effective for minimizing the risk of cerebral embolization, even in patients with asymptomatic carotid artery stenosis, despite slightly longer procedure and fluoroscopy times.
Using Propensity Scores to Examine the Association Between Behavioral Inhibition/Activation and Nonsuicidal and Suicidal Self-Injury
Authors: Ammerman Brooke A. , Kleiman Evan M. , Jenkins Abbigail L. , Berman Mitchell E. , McCloskey Michael S.
Published: November 2016

Abstract. Background: Self-injurious behavior (e.g., nonsuicidal self-injury, suicide attempts) is a serious public health concern. One potentially important but understudied predictor of nonsuicidal and suicidal self-injury involves the behavioral inhibition and activation system (BIS/BAS). Aims: The goal of the current study was to examine the relationship between nonsuicidal and suicidal self-injury and BIS/BAS, and to consider the influence of related variables in the relationship. Examination through this framework allowed us to consider BIS and BAS as potential unique risk factors of self-injury. Method: After examining the relationship between nonsuicidal and suicidal self-injury and BIS/BAS among 1,912 participants, we used propensity scores to match participants' propensity for nonsuicidal self-injury and suicide attempts based on demographic variables (e.g., gender, age) and related risk factors (e.g., anxiety, depressive symptomology, impulsivity, and substance use problems). Results: Participants who reported nonsuicidal self-injury or attempted suicide scored higher on BIS and BAS compared with those without a history of these behaviors. After matching procedures, however, the only group difference found was on BIS between those with and without a history of nonsuicidal self-injury. Conclusion: Results support the notion that the behavioral inhibition system might play a role in nonsuicidal self-injury but not in suicidal self-injury.
Toward a Shared Understanding of Important Consequences of Personality
Authors: Wessels Nele M. , Zimmermann Johannes , Leising Daniel
Published: November 2016

The assumption that personality makes a difference in people's everyday lives is probably the main reason why investigating personality seems worthwhile at all. Although the number of empirical studies addressing the everyday consequences of personality is considerable, an overarching conceptual framework is missing. We present such a framework, using a version of the SORKC model from cognitive-behavioral therapy. Our version of the model incorporates a full account of how personality may influence the ways in which people perceive and respond to situations, which may ultimately have important consequences for them and others. However, not everything that formally qualifies as a consequence of personality is equally relevant. In choosing criterion variables for their own research, researchers interested in personality consequences seem to have strongly relied on implicit assumptions regarding a “good life.” We review a sample of recent studies from the personality literature, using our own conceptualization of important personality consequences to assess the current state of the field, and deduce recommendations for future research.
Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding
Authors: Glick Casey C. , Srimongkol Mitchell T. , Schwartz Aaron J. , Zhuang William S. , Lin Joseph C. , Warren Roseanne H. , Tekell Dennis R. , Satamalee Panitan A. , Lin Liwei
Published: November 2016

A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes. Here, three-dimensional (3D) printed polymer molds are used to construct multilayer poly(dimethylsiloxane) (PDMS) devices by employing unique molding, bonding, alignment, and rapid assembly processes. Specifically, a novel single-layer, two-sided molding method is developed to realize two channel levels, non-planar membranes/valves, vertical interconnects (vias) between channel levels, and integrated inlet/outlet ports for fast linkages to external fluidic systems. As a demonstration, a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure, illustrating a high degree of flow rate control. In addition, multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels. Using integrated alignment marks to accurately position both stamps and individual layers, this technique is demonstrated by rapidly assembling a six-layer microfluidic device. By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS, this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems.
Red blood cell phase separation in symmetric and asymmetric microchannel networks: effect of capillary dilation and inflow velocity
Authors: Clavica Francesco , Homsy Alexandra , Jeandupeux Laure , Obrist Dominik
Published: November 2016

The non-uniform partitioning or phase separation of red blood cells (RBCs) at a diverging bifurcation of a microvascular network is responsible for RBC heterogeneity within the network. The mechanisms controlling RBC heterogeneity are not yet fully understood and there is a need to improve the basic understanding of the phase separation phenomenon. In this context, in vitro experiments can fill the gap between existing in vivo and in silico models as they provide better controllability than in vivo experiments without mathematical idealizations or simplifications inherent to in silico models. In this study, we fabricated simple models of symmetric/asymmetric microvascular networks; we provided quantitative data on the RBC velocity, line density and flux in the daughter branches. In general our results confirmed the tendency of RBCs to enter the daughter branch with higher flow rate (Zweifach-Fung effect); in some cases even inversion of the Zweifach-Fung effect was observed. We showed for the first time a reduction of the Zweifach-Fung effect with increasing flow rate. Moreover capillary dilation was shown to cause an increase of RBC line density and RBC residence time within the dilated capillary underlining the possible role of pericytes in regulating the oxygen supply.
Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet
Authors: Figueroa Ana Lucia C. , Figueiredo Hugo , Rebuffat Sandra A. , Vieira Elaine , Gomis Ramon
Published: November 2016

Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T). They were administered 2% taurine in their drinking water for 10 weeks. Mice were euthanized at 6:00, 12:00, 18:00, and 24:00. HFD mice increased body weight, visceral fat and food intake, as well as higher levels of glucose, insulin and leptin, throughout the 24 h. Taurine prevented increments in food intake, body weight and visceral fat, improved glucose tolerance and insulin sensitivity and reduced disturbances in the 24 h patterns of plasma insulin and leptin. HFD downregulated the expression of clock genes Rev-erbα, Bmal1, and Per1 in pancreatic islets. Taurine normalized the gene and protein expression of PER1 in beta-cells, which suggests that it could be beneficial for the correction of daily rhythms and the amelioration of obesity and diabetes.
Changes in sleep duration and risk of metabolic syndrome: the Kailuan prospective study
Authors: Song Qiaofeng , Liu Xiaoxue , Zhou Wenhua , Wang Xizhu , Wu Shouling
Published: November 2016

Using a large longitudinal data set spanning 4 years, we examined whether a change in self-reported sleep duration is associated with metabolic syndrome (MetS). Current analysis included 15,753 participants who were free of MetS during both 2006–2007 and 2010–2011. Sleep duration was categorized into seven groups: ≤5.5 h, 6.0–6.5 h, 7.0 h, 7.5–8.0 h, ≥8.5 h, decrease ≥2 h, and increase ≥2 h. Cox proportional hazards models were used to calculate hazard ratios (HRs) and their confidence intervals (CI) for MetS, according to sleep duration. Compared to the reference group of persistent 7-h sleepers, a decrease of ≥2 h sleep per night was associated with a higher risk of incident MetS (HR = 1.23, 95% CI = 1.05–1.44) in analyses adjusted for age, sex, sleep duration at baseline, marital status, monthly income per family member, education level, smoking status, drinking status, physical activity, body mass index, snoring status and resting heart rate. An increased risk of MetS incidence was also observed in persistent short sleepers (average ≤5.5 h/night; HR = 1.22, 95% CI = 1.01–1.50). This study suggests individuals whose sleep duration decreases ≥2 h per night are at an increased risk of MetS.
mRNA changes in nucleus accumbens related to methamphetamine addiction in mice
Authors: Zhu Li , Li Jiaqi , Dong Nan , Guan Fanglin , Liu Yufeng , Ma Dongliang , Goh Eyleen L. K. , Chen Teng
Published: November 2016

Methamphetamine (METH) is a highly addictive psychostimulant that elicits aberrant changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the nucleus accumbens of mice, indicating a potential role of METH in post-transcriptional regulations. To decipher the potential consequences of these post-transcriptional regulations in response to METH, we performed strand-specific RNA sequencing (ssRNA-Seq) to identify alterations in mRNA expression and their alternative splicing in the nucleus accumbens of mice following exposure to METH. METH-mediated changes in mRNAs were analyzed and correlated with previously reported changes in non-coding RNAs (miRNAs and lncRNAs) to determine the potential functions of these mRNA changes observed here and how non-coding RNAs are involved. A total of 2171 mRNAs were differentially expressed in response to METH with functions involved in synaptic plasticity, mitochondrial energy metabolism and immune response. 309 and 589 of these mRNAs are potential targets of miRNAs and lncRNAs respectively. In addition, METH treatment decreases mRNA alternative splicing, and there are 818 METH-specific events not observed in saline-treated mice. Our results suggest that METH-mediated addiction could be attributed by changes in miRNAs and lncRNAs and consequently, changes in mRNA alternative splicing and expression. In conclusion, our study reported a methamphetamine-modified nucleus accumbens transcriptome and provided non-coding RNA-mRNA interaction networks possibly involved in METH addiction.
Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission
Authors: Li Fang , Fan Xiaoxue , Zhang Yu , Pang Lizhi , Ma Xiaonan , Song Meijia , Kou Junping , Yu Boyang
Published: November 2016

GRS is a drug combination of three active components including ginsenoside Rb1, ruscogenin and schisandrin. It derived from the well-known TCM formula ShengMai preparations, a widely used traditional Chinese medicine for the treatment of cardiovascular diseases in clinic. The present study explores the cardioprotective effects of GRS on myocardial ischemia/reperfusion (MI/R) injury compared with ShengMai preparations and investigates the underlying mechanisms. GRS treatment significantly attenuated MI/R injury and exhibited similar efficacy as Shengmai preparations, as evidenced by decreased myocardium infarct size, ameliorated histological features, the decrease of LDH production and improved cardiac function, and also produced a significant decrease of apoptotic index. Mechanistically, GRS alleviated myocardial apoptosis by inhibiting the mitochondrial mediated apoptosis pathway as reflected by inhibition of caspase-3 activity, normalization of Bcl-2/Bax levels and improved mitochondrial function. Moreover, GRS prevented cardiomyocytes mitochondrial fission and upregulated AMPKα phosphorylation. Interestingly, AMPK activation prevented hypoxia and reoxygenation induced mitochondrial fission in cardiomyocytes and GRS actions were significantly attenuated by knockdown of AMPKα. Collectively, these data show that GRS is effective in mitigating MI/R injury by suppressing mitochondrial mediated apoptosis and modulating AMPK activation-mediated mitochondrial fission, thereby providing a rationale for future clinical applications and potential therapeutic strategy for MI/R injury.
Using instrumental variables to disentangle treatment and placebo effects in blinded and unblinded randomized clinical trials influenced by unmeasured confounders
Authors: Chaibub Neto Elias
Published: November 2016

Clinical trials traditionally employ blinding as a design mechanism to reduce the influence of placebo effects. In practice, however, it can be difficult or impossible to blind study participants and unblinded trials are common in medical research. Here we show how instrumental variables can be used to quantify and disentangle treatment and placebo effects in randomized clinical trials comparing control and active treatments in the presence of confounders. The key idea is to use randomization to separately manipulate treatment assignment and psychological encouragement conversations/interactions that increase the participants’ desire for improved symptoms. The proposed approach is able to improve the estimation of treatment effects in blinded studies and, most importantly, opens the doors to account for placebo effects in unblinded trials.
An ortholog of LEAFY in Jatropha curcas regulates flowering time and floral organ development
Authors: Tang Mingyong , Tao Yan-Bin , Fu Qiantang , Song Yaling , Niu Longjian , Xu Zeng-Fu
Published: November 2016

Jatropha curcas seeds are an excellent biofuel feedstock, but seed yields of Jatropha are limited by its poor flowering and fruiting ability. Thus, identifying genes controlling flowering is critical for genetic improvement of seed yield. We isolated the JcLFY, a Jatropha ortholog of Arabidopsis thaliana LEAFY (LFY), and identified JcLFY function by overexpressing it in Arabidopsis and Jatropha. JcLFY is expressed in Jatropha inflorescence buds, flower buds, and carpels, with highest expression in the early developmental stage of flower buds. JcLFY overexpression induced early flowering, solitary flowers, and terminal flowers in Arabidopsis, and also rescued the delayed flowering phenotype of lfy-15, a LFY loss-of-function Arabidopsis mutant. Microarray and qPCR analysis revealed several flower identity and flower organ development genes were upregulated in JcLFY-overexpressing Arabidopsis. JcLFY overexpression in Jatropha also induced early flowering. Significant changes in inflorescence structure, floral organs, and fruit shape occurred in JcLFY co-suppressed plants in which expression of several flower identity and floral organ development genes were changed. This suggests JcLFY is involved in regulating flower identity, floral organ patterns, and fruit shape, although JcLFY function in Jatropha floral meristem determination is not as strong as that of Arabidopsis.
Anisotropic Strain Induced Directional Metallicity in Highly Epitaxial LaBaCo2O5.5+δ Thin Films on (110) NdGaO3
Authors: Ma Chunrui , Han Dong , Liu Ming , Collins Gregory , Wang Haibin , Xu Xing , Lin Yuan , Jiang Jiechao , Zhang Shengbai , Chen Chonglin
Published: November 2016

Highly directional-dependent metal-insulator transition is observed in epitaxial double perovskite LaBaCo2O5.5+δ films. The film exhibit metallic along [100], but remain semiconducting along [010] under application of a magnetic field parallel to the surface of the film. The physical origin for the properties is identified as in-plane tensile strain arising from oxygen vacancies. First-principle calculations suggested the tensile strain drastically alters the band gap, and the vanishing gap opens up [100] conduction channels for Fermi-surface electrons. Our observation of strain-induced highly directional-dependent metal-insulator transition may open up new dimension for multifunctional devices.
Tuning the electrical conductance of metalloporphyrin supramolecular wires
Authors: Noori Mohammed , Aragonès Albert C. , Di Palma Giuseppe , Darwish Nadim , Bailey Steven W. D. , Al-Galiby Qusiy , Grace Iain , Amabilino David B. , González-Campo Arántzazu , Díez-Pérez Ismael , Lambert Colin J.
Published: November 2016

In contrast with conventional single-molecule junctions, in which the current flows parallel to the long axis or plane of a molecule, we investigate the transport properties of M(II)-5,15-diphenylporphyrin (M-DPP) single-molecule junctions (M=Co, Ni, Cu, or Zn divalent metal ions), in which the current flows perpendicular to the plane of the porphyrin. Novel STM-based conductance measurements combined with quantum transport calculations demonstrate that current-perpendicular-to-the-plane (CPP) junctions have three-orders-of-magnitude higher electrical conductances than their current-in-plane (CIP) counterparts, ranging from 2.10−2 G0 for Ni-DPP up to 8.10−2 G0 for Zn-DPP. The metal ion in the center of the DPP skeletons is strongly coordinated with the nitrogens of the pyridyl coated electrodes, with a binding energy that is sensitive to the choice of metal ion. We find that the binding energies of Zn-DPP and Co-DPP are significantly higher than those of Ni-DPP and Cu-DPP. Therefore when combined with its higher conductance, we identify Zn-DPP as the favoured candidate for high-conductance CPP single-molecule devices.
Correction: Corrigendum: Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens
Authors: Jain Pallavi , Neveu Bertrand , Velot Lauriane , Wu Lily , Fradet Yves , Pouliot Frédéric
Published: November 2016

Scientific Reports 6: Article number: 33968; published online: 28 September 2016; updated: 21 November 2016.
Erratum: Lipid membrane-mediated attraction between curvature inducing objects
Authors: van der Wel Casper , Vahid Afshin , Šarić Anđela , Idema Timon , Heinrich Doris , Kraft Daniela J.
Published: November 2016

Scientific Reports 6: Article number: 32825; published online: 13 September 2016; updated: 21 November 2016.
Irradiance-dependent UVB Photocarcinogenesis
Authors: Lan Cheng-Che E. , Wu Ching-Shuang , Huang Shu-Mei , Wu Chin-Han , Lai Hsiao-Chi , Peng Yu-Ting , Hou Pao-Sheng , Yang Hui-Jun , Chen Gwo-Shing
Published: November 2016

Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart. Mechanistically, using cell models, we demonstrated that LI UVB radiation allowed more keratinocytes harboring DNA damages to enter cell cycle via ERK-related signaling as compared to its HI UVB counterpart. These results indicated that at equivalent exposure, UVB radiation at LI has higher photocarcinogenic potential as compared to its HI counterpart. Since erythema is the observed sunburn at moderate doses and use of sunscreen was not found to associate with reduced sunburn episodes, the biological significance of sunburn with or without sunscreen use warrants further investigation.