bluuebunny/crossref_metadata_2025 huggingface dataset:
Types of infractions of trademark property rights. Аnalysis of judicial practice
Authors: Minchenko Nataliia
Published: December 2021

Keywords: Property rights to the trademark, infractions of property rights, judicialpractice, protection of trademark rights, invalidation of the trademark certificate,early termination of the certificate

The relevance of this article is that the largest number of legaldisputes in the sphere of intellectual property is disputes concerning violation of propertyrights for trademarks. The article examined the theoretical provisions of propertyrights for trademarks, as well as practical issues of violations of these rights. Specialattention is paid to the analysis of judicial practice concerning protection of rightsto trademarks. The categories of the mentioned cases have been highlighted and discussedin detail, statistical data and decisions have been made. It has been found thatthe overwhelming number of cases investigated concerns recognition of the Ukrainiantrademark certificate as invalid.The court cases on protection of rights to trademarks can be divided into severalcategories according to the claim requirements:1) On the recognition of the Ukrainian trademark certificate as invalid in whole orin part (for all or part of goods and/or services);2) On termination of infringement of intellectual property rights on the trademarkand obligation to take certain actions;3) On early termination of the Ukrainian trademark certificate in whole or in part(for all or part of goods and/or services);4) Other court cases. For example, the recognition of the non-legal patent ofUkraine for industrial design due to violation of rights for the registered trademark.The article contains detailed consideration of the mentioned categories of casesand statistical data about them.The analysis of judicial practice made it possible to establish the following statisticaldata: cases of invalidation of a trademark certificate are 47 %; cases on termination of infringementof rights to the trademark are 25 %; cases on early termination of the trademarkcertificate are 25 %; other cases on protection of rights to trademarks make 3 %.In addition, the analysis of court practice allowed to establish that 75 % of courtcases concerning protection of rights to trademarks are decided to satisfy the claim infull or in part.
Criminal liability for committing crimes in the sphere intellectual property under the laws of foreign countries
Authors: Nedohibchenko Yevheniia
Published: December 2021

Keywords: intellectual property, copyright and related rights, objects of industrialproperty, means of individualization, criminal liability, crimes against intellectualproperty

The article providesan overview of individual articles of the criminal codes of Ukraine, the Republic ofLatvia, Georgia and the People's Republic of China. These articles have constituted crimes against intellectual property. Statistics on the number of sentences in cases ofinfringement of intellectual property rights in Ukraine for 10 years.The rapid development of science and technology in the 21st century is creatingnew impetus for scientific research. There is a need to update national legislation.New approaches to intellectual property protection continue to be sought around theworld. Issues of crime in the field of intellectual property are becoming relevant anddiscussed among scientists, authors, inventors.The author gives examples of the Criminal Codes of Ukraine, the Republic ofLatvia, Georgia, and the People's Republic of China. The experience of the People'sRepublic of China is logical, correct in legal terms.Intellectual property provides economic benefits. Ago crimes against intellectualproperty should be classified as economic. According to the author, the Ukrainian authoritieswill be faced with new demands from foreign partners, including the EU, tostrengthen the fight against crime in this area under the threat of significant internationaleconomic sanctions. The proposed changes are aimed at eliminating gaps inlegislation and avoiding errors in the application of the Criminal Code of Ukraine bylaw enforcement agencies.
Critical Future Studies and Age: attending to future imaginings of age and ageing
Authors: Raisborough Jayne , Susan Watkins
Published: December 2021

This paper draws on cultural gerontology and literary scholarship to call for greater academic consideration of age and ageing in our imaginations of the future.  Our work adds to the development of Critical Future Studies (CFS) previously published in this journal, by arguing that prevailing ageism is fuelled by specific constructions of older populations as a future demographic threat and of ageing as a future undesirable state requiring management and control.  This paper has two parts: the first considers the importance of the future to contemporary ageist stereotypes. The second seeks potential counter representations in speculative fiction.  We argue that an age-aware CFS can allow us not only to imagine newfutures but also to reflect critically on the shape and consequences of contemporary modes of relations of power.
External Mechanical Work in Runners With Unilateral Transfemoral Amputation
Authors: Murata Hiroto , Hisano Genki , Ichimura Daisuke , Takemura Hiroshi , Hobara Hiroaki
Published: December 2021

Carbon-fiber running-specific prostheses have enabled individuals with lower extremity amputation to run by providing a spring-like leg function in their affected limb. When individuals without amputation run at a constant speed on level ground, the net external mechanical work is zero at each step to maintain a symmetrical bouncing gait. Although the spring-like “bouncing step” using running-specific prostheses is considered a prerequisite for running, little is known about the underlying mechanisms for unilateral transfemoral amputees. The aim of this study was to investigate external mechanical work at different running speeds for unilateral transfemoral amputees wearing running-specific prostheses. Eight unilateral transfemoral amputees ran on a force-instrumented treadmill at a range of speeds (30, 40, 50, 60, 70, and 80% of the average speed of their 100-m personal records). We calculated the mechanical energy of the body center of mass (COM) by conducting a time-integration of the ground reaction forces in the sagittal plane. Then, the net external mechanical work was calculated as the difference between the mechanical energy at the initial and end of the stance phase. We found that the net external work in the affected limb tended to be greater than that in the unaffected limb across the six running speeds. Moreover, the net external work of the affected limb was found to be positive, while that of the unaffected limb was negative across the range of speeds. These results suggest that the COM of unilateral transfemoral amputees would be accelerated in the affected limb’s step and decelerated in the unaffected limb’s step at each bouncing step across different constant speeds. Therefore, unilateral transfemoral amputees with passive prostheses maintain their bouncing steps using a limb-specific strategy during running.
A Targeted Approach to Improve Asthma Control Using Community Pharmacists
Authors: Serhal Sarah , Saini Bandana , Bosnic-Anticevich Sinthia , Krass Ines , Emmerton Lynne , Bereznicki Bonnie , Bereznicki Luke , Mitchell Bernadette , Wilson Frances , Wright Bronwen , Wilson Kiara , Weier Naomi , Segrott Rebecca , Cleveland Rhonda , Jan Stephen , Shan Sana , Billot Laurent , Armour Carol
Published: December 2021

Background: Building on lessons learnt from evidence-based community pharmacy asthma management models, a streamlined and technology supported Pharmacy Asthma Service (PAS) was developed to promote the integration of the service into routine practice.

Objective: This study investigates the efficacy of the PAS in improving asthma symptom control and other health outcomes.

Methods: A two-arm pragmatic cluster randomized controlled trial was implemented in 95 pharmacies across three Australian States. Participants were adults with poorly controlled asthma as per the Asthma Control Questionnaire (ACQ), with or without allergic rhinitis. Patients within the PAS arm engaged in four consultations with the pharmacist over a 12-month period. An evidence-based algorithm guided pharmacies, via a trial specific software, to deliver a series of interventions targeting three issues underpinning uncontrolled asthma (medication use and adherence, inhaler technique, and allergic rhinitis management) to patient clinical asthma status and patient need. Comparator arm patients received a minimal intervention likened to usual practice involving referral of eligible patients to the GP and two follow-up consultations with their pharmacist to collect comparative data.

Results: In total, 143 of 221 PAS patients (65%) and 111 of 160 comparator patients (69%) completed the trial. Improvements in asthma control were achieved in both the PAS (mean difference (MD) in ACQ from baseline = −1.10, p <.0001) and comparator (MD in ACQ from baseline = −0.94, p <.0001) arms at the trial end; however, there were no significant differences between the two arms (MD = −0.16, 95% CI −0.41 to 0.08, p = 0.19). Patients’ quality of life in the PAS arm improved significantly when compared with the comparator arm (MD in Impact of Asthma on Quality-of-Life Questionnaire (IAQLQ) = −0.52, 95% CI −0.89 to −0.14, p = 0.0079).

Conclusion: Despite the PAS achieving a greater improvement in patients’ quality of life, the pharmacist-led service and usual practice arm produced comparable improvements in asthma control. These results ask us to reflect on current standards of usual care, as it appears the standard of asthma care in usual practice has evolved beyond what is reported in the literature.
The Circle of Life: The Mathematics of Predator-Prey Relationships
Authors: Brady Rebecca M. , Butler John S.
Published: December 2021

Some animals hunt other animals to feed themselves; these animals are called predators. Animals who are hunted and eaten are known as prey. What do you think would happen if a predator were introduced to an ecosystem where the prey previously lived without fear of being hunted? Would the new predator eat all the prey animals until they go extinct? Actually, the relationship between predator and prey is far more interesting than this. In this article, we show what the predator-prey relationship looks like over time and explain how scientists can make predictions about future population levels, all using basic mathematics like addition, subtraction, and multiplication.
Oregano (Origanum vulgare L.) Essential Oil Feed Supplement Protected Broilers Chickens against Clostridium perfringens Induced Necrotic Enteritis
Authors: Jin Xiaolu , Huang Guanggen , Luo Zheng , Hu Yongfei , Liu Dan
Published: December 2021

Oregano (Origanum vulgare L.) is a well-known traditional medicine and a cooking spice. Recent practice has also applied the essential oil from oregano (OEO) in poultry due to its great potential for an antibiotic alternative. Our objective was to evaluate the potential effects of OEO (with carvacrol and thymol as the main active ingredient) on preventing necrotic enteritis (NE) caused by Clostridium perfringens (Cp) in chickens. In the feeding trial, a total of 450 one-day-old commercial Arbor Acres broilers were randomly assigned in 5 experimental groups during a 26-day production period (d19 to d 26 was the Cp challenge stage), and each group consisted of 6 replicate pens (15 birds each pen). All treatments were: basal diet (control group); basal diet and Cp challenge (model group); Cp challenge and 10 mg/kg enramycin (positive control group); Cp challenge and 200 mg/kg OEO product (OEO low dosage group, OEOL); Cp challenge and 300 mg/kg OEO product (OEO high dosage group, OEOH). OEO feed supplement at both dosages had significant effects on increasing the body weight gain (BWG) and reversing the dropped feed intake (FI) induced by Cp challenge. Histopathological changes in the ileums of broiler chickens with NE induced by Cp were alleviated by OEO, which was mutually confirmed by the intestinal lesion scores. Dosage did not influence the protective effect of OEO on intestinal lesion scores. Furthermore, OEO was found to have limited effects on tight junction-related gene expressions (Occludin and ZO-1). The broilers of the OEOL and OEOH groups significantly decreased the expression of TNF-α mRNA in the ileum and only the OEOH group was found to inhibit the IFN-γ expression of IFN- induced by Cp challenge. Finally, despite the fact that in vitro antibacterial effects by OEO were observed, considering its high minimum inhibitory concentration (MIC) value, we inferred that the protective effects by OEO against Cp challenge were not attributable to its direct antibacterial effects. We proposed OEO as a promising substitute for antibiotics against NE induced by Cp during poultry production.
No-Antibiotic-Pectin-Based Treatment Differently Modified Cloaca Bacteriobiome of Male and Female Broiler Chickens
Authors: Lysko Svetlana B. , Baturina Olga A. , Naumova Natalia B. , Lescheva Nadezhda A. , Pleshakova Valentina I. , Kabilov Marsel R.
Published: December 2021

As the information about the effect of pectin prebiotics on chicken gut microbiota is scarce, by using high throughput metagenomic sequencing with Illumina Miseq we examined the cloaca bacteriobiome of male and female chickens receiving antibiotic- or pectin-containing drinking water. The bacteriobiome was dominated by two phyla (Firmicutes and Proteobacteria) and three classes (Clostridia, Bacilli and Gammaproteobacteria), with the difference displayed by the relative abundance of 42 OTUs. At the level of the major dominant OTUs, prebiotic supplementation drastically increased Enterococcus abundance (from 0 to 11% and 23% in males and females, respectively). The better feed use efficiency and growth performance of the pectin-receiving chickens implied their better health and corroborated putative beneficial role of the altered bacteriobiome, although its ecophysiological and/or pathogenic importance could not be readily inferred. Notably, the gut microbiota response to antibiotics showed more sex-related differential OTUs as compared to the pectin prebiotic (19 vs. 4), suggesting different mechanisms of the studied supplementations in shaping the gut bacteriobiome in different sexes. Therefore, we recommend targeting sex as a separate factor in interventional studies to account for sex-specific peculiarities in the microbiome response and taking into account the male/female ratio of industrial flocks prior to choosing a production technology. The studied prebiotic (pectin) can be used in developing new pre/symbiotic preparations and supplementation regimes as alternatives to antibiotics for stimulating broiler chicken production.
Rapid Detection of Urea Fertilizer Effects on VOC Emissions from Cucumber Fruits Using a MOS E-Nose Sensor Array
Authors: Tatli Sana , Mirzaee-Ghaleh Esmaeil , Rabbani Hekmat , Karami Hamed , Wilson Alphus Dan
Published: December 2021

The widespread use of nitrogen chemical fertilizers in modern agricultural practices has raised concerns over hazardous accumulations of nitrogen-based compounds in crop foods and in agricultural soils due to nitrogen overfertilization. Many vegetables accumulate and retain large amounts of nitrites and nitrates due to repeated nitrogen applications or excess use of nitrogen fertilizers. Consequently, the consumption of high-nitrate crop foods may cause health risks to humans. The effects of varying urea–nitrogen fertilizer application rates on VOC emissions from cucumber fruits were investigated using an experimental MOS electronic-nose (e-nose) device based on differences in sensor-array responses to volatile emissions from fruits, recorded following different urea fertilizer treatments. Urea fertilizer was applied to cucumber plants at treatment rates equivalent to 0, 100, 200, 300, and 400 kg/ha. Cucumber fruits were then harvested twice, 4 and 5 months after seed planting, and evaluated for VOC emissions using an e-nose technology to assess differences in smellprint signatures associated with different urea application rates. The electrical signals from the e-nose sensor array data outputs were subjected to four aroma classification methods, including: linear and quadratic discriminant analysis (LDA-QDA), support vector machines (SVM), and artificial neural networks (ANN). The results suggest that combining the MOS e-nose technology with QDA is a promising method for rapidly monitoring urea fertilizer application rates applied to cucumber plants based on changes in VOC emissions from cucumber fruits. This new monitoring tool could be useful in adjusting future urea fertilizer application rates to help prevent nitrogen overfertilization.
Foliar Application of Protein Hydrolysates on Baby-Leaf Spinach Grown at Different N Levels
Authors: Bonasia Anna , Conversa Giulia , Lazzizera Corrado , Elia Antonio
Published: December 2021

Surpluses of N are associated with environmental and health problems. To optimise N use and reduce nitrate accumulation in leafy species like spinach, the application of biostimulants is suggested. An experiment in controlled conditions (growth chamber/soilless) evaluated baby-spinach responses to two protein hydrolysates (PHs) from plant (legume, Trainer®) and animal (meat, Isabion®) sources, combined with three N rates: 2 (N2, deficient), 8 (N8, sub-optimal), and 14 (N14, optimal) mM of N. Biometrical and morphological traits of shoots and roots as well as the physio-metabolic (gas exchange, N assimilation, and NUtE), physical, mineral, and antioxidant profiles of leaves were assessed. The legume-PH boosts growth and yield only at the highest N conditions, while there was no effect at lower N rates. The legume-PH modulates root architecture and chlorophylls has positive responses only at optimal N availability, such as an increase in N uptake, leaf expansion, and photosynthetic activity at the canopy level. The PHs do not improve NUtE, leaf colour, consistency, cations, or antioxidants. Neither do PHs have any effect on reducing nitrate accumulation. Legume-PH improves N assimilation only at optimal N availability, while meat-PH does not, reaching the highest nitrate value at the highest N rate (2677 mg kg−1 fw), even if this value is under the EC limits for fresh spinach.
Research on the Industrial Upgrade of Vegetable Growers in Shaanxi: A Cross-Regional Comparative Analysis of Experience Reference
Authors: Wang Hongyu , Sarkar Apurbo , Rahman Airin , Hossain Md. Shakhawat , Memon Waqar Hussain , Qian Lu
Published: December 2021

The prime goals of this article are to classify farmers’ production structures in different regions through comparative analysis and propose a structural framework that can quantify the transformation and upgrade of the vegetable industry in Shaanxi. The study utilized New Structural Economics (NSE) theory to construct the theoretical model, and the empirical data set has been crafted from 1992 vegetable growers in the Shaanxi, Hebei, and Shandong provinces. We qualitatively evaluated the potentiality of the Shaanxi vegetable industry, facilitating an industrial upgrade by drawing on the development experience of other regions. More specifically, we utilized the tomato growers to construct a five-step analysis method to transform and upgrade the vegetable industries. This article found that the chosen three provinces have structural differences and similarities in their production sides, and, compared with Hebei and Shandong, the vegetable industry in Shaanxi is still in the catching-up stage. Hebei has similar planting characteristics to Shaanxi, but the production characteristics of growers in Shaanxi are quite different from those in Shandong. Therefore, tomato growers in Hebei are the desired learning object for growers in Shaanxi. By learning planting experience from Hebei growers, tomato growers in the Shaanxi Province can improve their yield and product quality. We found that Shaanxi farmers have 15.57 percent improvement potential in improving crop management and rational allocation of production materials. Proper information-sharing platforms should be implemented to grasp consumption trends on the demand side and guide industrial upgrading.
The Role of Non-Coding RNA in Rice Immunity
Authors: Nadarajah Kalaivani K. , Abdul Rahman Nur Sabrina Natasha
Published: December 2021

Disease has been a major concern in the rice-growing sector, resulting in significant losses and compromised food security. To combat disease, plants have devised various defense strategies. Initial works in understanding plant–pathogen interactions were focused on discovering resistance and pathogenicity genes, as well as analyzing the functions of these genes in the host defense. Later, researchers discovered that regulatory elements, such as transcription factors, were essential players in modulating plant defenses. As the depth of research and knowledge in this field increased, non-coding RNA (ncRNA) were discovered to play key functions in plant immunity. In this review, we explore the contribution and interaction of microRNAs (miRNAs), long ncRNAs (lncRNAs), and small interfering RNAs (siRNAs) in controlling the rice immune response. The role and the interaction between ncRNAs and their targets have been discussed in detail. We believe that this information will be beneficial in disease resistance breeding of rice.
Utilization of By-Product of Groundnut Oil Processing for Production of Prodigiosin by Microbial Fermentation and Its Novel Potent Anti-Nematodes Effect
Authors: Nguyen Thi Hanh , Wang San-Lang , Doan Manh Dung , Nguyen Thi Huyen , Tran Thi Ha Trang , Tran Thi Ngoc , Doan Chien Thang , Ngo Van Anh , Ho Nhat Duoc , Do Van Chung , Nguyen Anh Dzung , Nguyen Van Bon
Published: December 2021

This study aimed to reuse groundnut oil processing by-product, groundnut cake (GNC) for the low-cost production of prodigiosin (PG) via microbial technology and to assess its novel potential application for the management of black pepper nematodes. Serratia marcescens TUN02 was found as the most active PG-producing strain. Various small-scale experiments conducted in flasks indicated that GNC at 1% may be used as the sole carbon/nitrogen source for cost-effective PG production by fermentation. Notably, no further commercial ingredients and salts are required to supplement into the culture medium of this fermentation. PG was further investigated for scale-up production in a 14-L bioreactor system and PG was produced at high yield (6886 mg/L) with large-scale volume (4 L) in a short cultivation time (10 h). PG was then purified and its nematicidal activity was evaluated and showed effective inhibition of juveniles and egg hatching of Meloidogyne incognita species, harmful on black pepper, with low IC50 values of 0.2 and 0.32 mg/mL, respectively. The simple medium containing 1% GNC is the first report of cost-effective biosynthesis of PG, as well as potential in vitro anti-egg hatching activity of PG. These results indicated the potential application of GNC for low-cost bioproduction of PG for promising and novel use in the management of black pepper nematodes.
Fertilizer Effects on Endosperm Physicochemical Properties and Resistance to Larger Grain Borer, Prostephanus truncatus (Coleoptera: Bostrichidae), in Malawian Local Maize (Zea mays L.) Varieties: Potential for Utilization of Ca and Mg Nutrition
Authors: Nguma Ephantus , Munthali Chandiona , Murayama Daiki , Onishi Kazumitsu , Mori Masahiko , Kinoshita Rintaro , Yamashita Shinji , Kinoshita Mikio , Tani Masayuki , Palta Mari , Palta Jiwan P. , Koaze Hiroshi , Aiuchi Daigo
Published: December 2021

Maize grain hardness influences storage pest resistance, a key characteristic valued by smallholder farmers. The structural changes in the endosperm determine grain hardness and are influenced by agronomic practices. The purpose of this study was to establish whether supply of calcium and magnesium based fertilizers can alter physicochemical properties of local and hybrid maize varieties and reduce the infestation by larger grain borer (Prostephanus truncatus (Coleoptera: Bostrichidae)) during storage. Two local and one hybrid maize varieties commonly grown by smallholder farmers in Malawi were cultivated under three fertilizer treatments (NPK (nitrogen, phosphorous, potassium), NPK plus gypsum, and NPK plus dolomite). After harvest, the grains were classified into flint and dent types, followed by P. truncatus infestation and determination of their physicochemical properties. The addition of gypsum and dolomite fertilizers led to higher levels of amylose, total zein and β-14 zein, traits associated with kernel hardness, compared to the application of NPK fertilizer. Moreover, local maize varieties showed higher resistance to P. truncatus infestation, hardness and biochemical properties associated with hardness (total zein, α-19 and β-14 zein, starch lysophosphatidylcholine, and non-starch free fatty acid) compared to hybrid variety. Our study suggests the potential for utilizing Ca and Mg nutrition in maize to improve kernel hardness, thus adoption of gypsum and dolomite by smallholder farmers may be beneficial against P. truncatus during storage.
Effect of Vacuum Level and Pulsation Parameters on Milking Efficiency and Animal Welfare of Murciano-Granadina Goats Milked in Mid-Line and Low-Line Milking Machines
Authors: Romero Gema , Bueso-Ródenas Joel , Alejandro Manuel , Moya Francisco , Díaz José Ramón
Published: December 2021

The Murciano-Granadina goat breed has been described as a slow milking breed. As milking machine parameters can affect milk extraction in terms of yield and time employed, two experiments of one-month duration were performed with 88 goats in Latin square design to find the best combination of these parameters. One of them was carried out in a mid-line milking machine and one in a low-line milking machine. For each of them, two vacuum levels (36 and 40 kPa), two pulsation rates (90 and 120 cycles/min) and two pulsator ratios (50 and 60%) were used and milking efficiency, sanitary status of the mammary gland, milk cortisol, and teat end status were evaluated. Results showed that in milking machines installed in mid- and low-line, the use of 40 kPa system vacuum, 60% pulsator ratio and 90 or 120 cycles/min pulsation rate achieved optimum milking fractioning and efficiency. In the case of low-level milking machines, a similar combination with 36 kPa not only showed worse milking fractioning values, but also provided better values of teat end status and cortisol level.
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
Authors: Claros Silvia , Cabrera Pablo , Valverde Nadia , Romero-Zerbo Silvana Y. , López-González Manuel Víctor , Shumilov Kirill , Rivera Alicia , Pavia Jose , Martín-Montañez Elisa , Garcia-Fernandez María
Published: December 2021

Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial dysfunction and neuronal glucocorticoid-induced toxicity. The insulin-like growth factor II (IGF-II), a pleiotropic hormone, has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. Our aim was to examine the protective effect of IGF-II on a dopaminergic cellular combined model of PD and mild to moderate stress measuring oxidative stress parameters, mitochondrial and neuronal markers, and signalling pathways. IGF-II counteracts the mitochondrial-oxidative damage produced by the toxic synergistic effect of corticosterone and 1-methyl-4-phenylpyridinium, protecting dopaminergic neurons from death and neurodegeneration. IGF-II promotes PKC activation and nuclear factor (erythroid-derived 2)-like 2 antioxidant response in a glucocorticoid receptor-dependent pathway, preventing oxidative cell damage and maintaining mitochondrial function. Thus, IGF-II is a potential therapeutic tool for treatment and prevention of disease progression in PD patients suffering mild to moderate emotional stress.
Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy
Authors: Sechi Gian Pietro , Bardanzellu Flaminia , Pintus Maria Cristina , Sechi Maria Margherita , Marcialis Maria Antonietta , Fanos Vassilios
Published: December 2021

On the basis that similar biochemical and histological sequences of events occur in the brain during thiamine deficiency and hypoxia/ischemia related brain damage, we have planned this review to discuss the possible therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE). Among the many benefits, thiamine per se as antioxidant, given intravenously (IV) at high doses, defined as dosage greater than 100 mg IV daily, should counteract the damaging effects of reactive oxygen and nitrogen species in the brain, including the reaction of peroxynitrite with the tyrosine residues of the major enzymes involved in intracellular glucose metabolism, which plays a key pathophysiological role in HIE in neonates. Accordingly, it is conceivable that, in neonatal HIE, the blockade of intracellular progressive oxidative stress and the rescue of mitochondrial function mediated by thiamine and its derivatives can lead to a definite neuroprotective effect. Because therapeutic hypothermia and thiamine may both act on the latent period of HIE damage, a synergistic effect of these therapeutic strategies is likely. Thiamine treatment may be especially important in mild HIE and in areas of the world where there is limited access to expensive hypothermia equipment.
Comparative Analysis of Three Trypanosomatid Catalases of Different Origin
Authors: Chmelová Ľubomíra , Bianchi Claretta , Albanaz Amanda T. S. , Režnarová Jana , Wheeler Richard , Kostygov Alexei Yu. , Kraeva Natalya , Yurchenko Vyacheslav
Published: December 2021

Most trypanosomatid flagellates do not have catalase. In the evolution of this group, the gene encoding catalase has been independently acquired at least three times from three different bacterial groups. Here, we demonstrate that the catalase of Vickermania was obtained by horizontal gene transfer from Gammaproteobacteria, extending the list of known bacterial sources of this gene. Comparative biochemical analyses revealed that the enzymes of V. ingenoplastis, Leptomonas pyrrhocoris, and Blastocrithidia sp., representing the three independent catalase-bearing trypanosomatid lineages, have similar properties, except for the unique cyanide resistance in the catalase of the latter species.
Fluorescence Lifetime Phasor Analysis and Raman Spectroscopy of Pigmented Organic Binders and Coatings Used in Artworks
Authors: Dal Fovo Alice , Mattana Sara , Chaban Antonina , Quintero Balbas Diego , Lagarto João Luis , Striova Jana , Cicchi Riccardo , Fontana Raffaella
Published: December 2021

Fluorescence analysis of materials used as binders and coatings in artworks is often hampered by numerous factors, leading to uncertainties in data interpretation. Fluorescence lifetime (FL) measurements enable improvement of the specificity with respect to steady-state measurements by resolving the decay dynamics of the fluorophore emissions. In this work, layers of natural resin, oil, and wax—in pure form, pigmented, in mixtures, and spread on different substrates—were analyzed using a compact, portable, fiber-based FL instrument. FL data were processed via the phasor method and integrated with Raman spectroscopy to obtain complementary chemical information on the different substances. It was observed that the τ-phase of the mixtures is affected by both the pigments and the dispersing medium, and that the presence of the metal substrate contributes to changes in the FL of mixtures. The results obtained with our portable FL system combined with Raman spectroscopy pave the way for a systematic study of a larger number of materials for future in situ applications on works of art.
Storm Surge Prediction Based on Long Short-Term Memory Neural Network in the East China Sea
Authors: Chen Kuo , Kuang Cuiping , Wang Lei , Chen Ke , Han Xuejian , Fan Jiadong
Published: December 2021

As an area frequently suffering from storm surge, the Yangtze River Estuary in the East China Sea requires fast and accurate prediction of water level for disaster prevention and mitigation. Due to storm surge process being affected by the long-term and short-term correlation of multiple factors, this study attempts to introduce a data-driven idea into the water level prediction during storm surge. By collecting the observed meteorological data and water level data of 12 typhoons from 1986 to 2016 at the Lusi tidal station of Jiangsu Province, China near the north branch of the Yangtze River Estuary, a Long Short-Term Memory (LSTM) neural network model was constructed by using multi-factor time series to predict the water level during the storm surge period. This study concludes that the LSTM model performs precisely for 1 h prediction of water level during the storm surge period and it can provide a 15 h prediction of water level within a limited error, and the prediction performance of the LSTM model is visibly superior to the four traditional ML models by 41% in terms of Accuracy Coefficient.
Biomechanical Assessment of Mobile-Bearing Total Knee Endoprostheses Using Musculoskeletal Simulation
Authors: Kebbach Maeruan , Soodmand Iman , Krueger Sven , Grupp Thomas M. , Woernle Christoph , Bader Rainer
Published: December 2021

The purpose of this computational study was to analyze the effects of different mobile-bearing (MB) total knee replacement (TKR) designs on knee joint biomechanics. A validated musculoskeletal model of the lower right extremity implanted with a cruciate-retaining fixed-bearing TKR undergoing a squat motion was adapted for three different MB TKR design variants: (I) a commercially available TKR design allowing for tibial insert rotation about the tibial tray with end stops to limit the range of rotation, (II) the same design without end stops, and (III) a multidirectional design with an additional translational degree-of-freedom (DoF) and end stops. When modeling the MB interface, two modeling strategies of different joint topologies were deployed: (1) a six DoF joint as a baseline and (2) a combined revolute-prismatic joint (two DoF joint) with end stops in both DoF. Altered knee joint kinematics for the three MB design variants were observed. The commercially available TKR design variant I yielded a deviation in internal-external rotation of the tibial insert relative to the tray up to 5° during knee flexion. Compared to the multidirectional design variant III, the other two variants revealed less femoral anterior-posterior translation by as much as 5 mm. Concerning the modeling strategies, the two DoF joint showed less computation time by 68%, 80%, and 82% for design variants I, II, and III, respectively. However, only slight differences in the knee joint kinematics of the two modeling strategies were recorded. In conclusion, knee joint biomechanics during a squat motion differed for each of the simulated MB design variants. Specific implant design elements, such as the presence of end stops, can impact the postoperative range of knee motion with regard to modeling strategy, and the two DoF joint option tested accurately replicated the results for the simulated designs with a considerably lower computation time than the six DoF joint. The proposed musculoskeletal multibody simulation framework is capable of virtually characterizing the knee joint dynamics for different TKR designs.
Monitoring of Liquid Viscosity for Viscous Dampers through a Wireless Impedance Measurement System
Authors: Jia Sihui , Luo Mingzhang
Published: December 2021

Viscous dampers are a type of seismic damping equipment widely used in high-rise buildings and bridges. However, the viscosity of the damping fluid inside the viscous damper will change over time during its use, which significantly reduces the seismic performance of the viscous damper. Hence, it is necessary to monitor the viscosity of the fluid inside the damper over its service life. In this paper, a damping fluid viscosity monitoring method based on wireless impedance measurement technology is proposed. A piezoelectric sensor is installed in a damper cylinder specimen, and the viscosity of the damping fluid is determined by measuring the piezoelectric impedance value of the sensor. In this study, 10 samples of damping fluids with different viscosities are tested. In order to quantitatively correlate damping fluid viscosity and electrical impedance, a viscosity index (VI) based on the root mean square deviation (RMSD) is proposed. The experimental results show that the variation of the real part in the impedance signal can qualitatively determine the damping fluid viscosity while the proposed VI can effectively and quantitatively identify the damping fluid viscosity.
Reuse of Pruning Waste from Subtropical Fruit Trees and Urban Gardens as a Source of Nutrients: Changes in the Physical, Chemical, and Biological Properties of the Soil
Authors: Reyes-Martín Marino Pedro , Ortiz-Bernad Irene , Lallena Antonio M. , San-Emeterio Layla M. , Martínez-Cartas M. Lourdes , Ondoño Emilia Fernández
Published: December 2021

A field experiment was conducted on the Andalusian coast (Granada, Southern Spain) to study the time course of nutrient release into the soil after the addition of bagged pruning waste from subtropical orchard trees (avocado, cherimoya, and mango) and urban garden waste over three two-year periods. N, P, and K concentrations were greater in the garden waste, whilst avocado and cherimoya pruning waste registered the highest values for Mg. In general, micronutrient contents were low in all waste, especially Cu. Macronutrient release followed a three-phase dynamic: fast initial release, intermediate stabilization, and final increase. Garden waste showed a similar time course in all three trees and released greater concentrations of K and P. The annual decomposition rate factor k was negative for N and Ca in the avocado tree, indicating strong biological activity in this plot. Avocado, cherimoya, and garden waste showed a good microbial degradation, improving soil quality by increasing carbon and nitrogen contents as well as soil microbial activity. As for the mango tree, its special microclimatic conditions appeared to favor waste photodegradation, thus eliminating nutrients that were not incorporated into the soil. Soil enzymatic activities increased in the avocado and cherimoya trees with the addition of all waste. In the mango tree, only an increase in urease was detected after the addition of garden waste. Our results suggest that the time course of organic waste in different subtropical trees grown on similar soils is significantly conditioned by the microclimatic characteristics.
Analysis of Synchronous Generators’ Local Mode Eigenvalues in Modern Power Systems
Authors: Ritonja Jožef , Polajžer Boštjan
Published: December 2021

New energy sources, storage facilities, power electronics devices, advanced and complex control concepts, economic operating doctrines, and cost-optimized construction and production of machines and equipment in power systems adversely affect small-signal stability associated with local oscillations. The objective of the article is to analyze local oscillations and the causes that affect them in order to reduce their negative impact. There are no recognized analyses of the oscillations of modern operating synchronous generators exposed to new conditions in power systems. The basic idea is to perform a numerical analysis of local oscillations of a large number of synchronous generators in the power system. The paper represents the local mode data obtained from a systematic analysis of synchronous generators in the Slovenian power system. Analyzed were 74 synchronous generators of the Slovenian power system, plus many additional synchronous generators for which data were accessible in references. The mathematical models convenient for the study of local oscillations are described first in the paper. Next, the influences of transmission lines, size of the synchronous generators, operating conditions, and control systems were investigated. The paper’s merit is the applicable rules that have been defined to help power plant operators avoid stability-problematic situations. Consequently, boundaries were estimated of the eigenvalues of local modes. Finally, experiments were performed with a laboratory-size synchronous generator to assess the regularity of the numerically obtained conclusions. The obtained results enable the prediction of local oscillations’ frequencies and dampings and will be useful in PSS planning.
Empirical Evaluation on Utilizing CNN-Features for Seismic Patch Classification
Authors: Zhang Chunxia , Wei Xiaoli , Kim Sang-Woon
Published: December 2021

This paper empirically evaluates two kinds of features, which are extracted, respectively, with traditional statistical methods and convolutional neural networks (CNNs), in order to improve the performance of seismic patch image classification. In the latter case, feature vectors, named “CNN-features”, were extracted from one trained CNN model, and were then used to learn existing classifiers, such as support vector machines. In this case, to learn the CNN model, a technique of transfer learning using synthetic seismic patch data in the source domain, and real-world patch data in the target domain, was applied. The experimental results show that CNN-features lead to some improvements in the classification performance. By analyzing the data complexity measures, the CNN-features are found to have the strongest discriminant capabilities. Furthermore, the transfer learning technique alleviates the problems of long processing times and the lack of learning data.
On-Board Flickering Pixel Dynamic Suppression Method Based on Multi-Feature Fusion
Authors: Jia Liangjie , Rao Peng , Chen Xin , Qiu Shanchang
Published: December 2021

The blind pixel suppression is the key preprocess to guarantee the real-time space-based infrared point target (IRPT) detection and tracking. Meanwhile, flickering pixels, as one of the blind pixels, is hard to suppress because of randomness. At present, common methods adopting a single feature generally need to accumulate dozens or hundreds of frames to ensure detection accuracy, which cannot update flickering pixels frequently. However, with low detection frequency, the flickering pixels are easily miss detected. In this paper, we propose an on-board flickering pixel dynamic suppression method based on multi-feature fusion. The visual and motion features of flickering pixels are extracted from the result of IRPT detection and tracking. Then, the confidence of flickering pixel evaluation strategy and selection mechanism of flickering pixel are introduced to fuse the above features, which achieves accurate flickering pixel suppression using a dozen frames. The experimental results evaluated on the real image of four scenarios show that the blind pixel false detection rate of the proposed method is no more than 1.02%. Meanwhile, evaluated on the simulated image, the flickering pixel miss suppression rate is no more than 2.38%, and the flickering pixel false suppression rate is 0. The proposed method could be an addition to most other IRPT detection methods, which guarantees the near-real-time and reliability of on-board IRPT detection applications.
Evaluation of the Operation Process of Medical Equipment to Enhance Ergonomic Reliability Based on FRAM–Moran’s I and CREAM
Authors: Liu Xin , Liu Zheng , Lin Kang-Chao , Huang Zhi-Lin , Ling Ming-Yu , Chen Peng-Qing , Huang Xiao-Min , Zhai Yu-Jia
Published: December 2021

To improve the ergonomic reliability of medical equipment design during the operation process, a method for evaluating the operating procedure of a medical equipment interface according to functional resonance analysis method (FRAM)-Moran’s I and cognitive reliability and error analysis method (CREAM) is proposed in this study. The novelty of this research is to analyze the ergonomic reliability of medical equipment in a more systematic manner and to minimize the impact of human subjectivity and individual differences on the evaluation results of the operation process. To solve the calculation problem of functional resonance in FRAM and to make the evaluation results more objective, Moran’s I was introduced to quantify the deviation degree caused by the individual differences of the subjects. By giving weights based on Moran’s I, the influence of individual differences and subjectivity on the evaluation results can be minimized, to a certain extent. Considering the importance of a special environment, which is not fully considered by the conventional CREAM, the weighting values based on Moran’s I, Delphi survey, and technique for order preference by similarity to an ideal solution (TOPSIS) were adopted to assign weights to common performance conditions (CPCs) in CREAM. The optimal design scheme was selected more objectively than in the conventional method. The validity and practicability of this operation process evaluation method was verified by a statistical method based on ergonomic reliability experiments.
A Multi-Component Physiotherapeutic Intervention among Schoolchildren with Myopia: 3D-Based Vision Training Program with Auditory Frequency Entrainment and Electrical Stimulation
Authors: Teng Yu-Kuei , Chang Chi-Wu , Lee Shin-Da
Published: December 2021

Purpose. This study evaluated whether 3D-based vision training (VT) with visual cortex-activated auditory frequency entrainment and bilateral orbital electrical stimulation (ES) could prevent the progression of myopia among schoolchildren. Methods. In this two-stage, randomized, crossover, single-blind study, pre- and post-logMAR visual acuity and refractive error from 27 schoolchildren with myopia (≤−0.50 D) were evaluated among four groups: (1) sham control with no VT, frequency following response (FFR), or ES (control group); (2) 3D-based VT only (VT group); (3) VT with FFR generated through visual cortex-activated auditory entrainment (VT-FFR group); and (4) VT with FFR and bilateral orbital ES (VT-FFR-ES group). In stage 1, the intervention was administered for 30 min to all groups using a randomized crossover design. In stage 2, the intervention was administered for 30 min/day, 3 days a week, for 4 weeks to evaluate the effectiveness of intervention. Results. Compared with the pre-test, post-test logMAR visual acuity after a single intervention was not significantly different in control and VT groups, but significantly improved in the VT-FFR (−0.08 ± 0.11) and VT-FFR-ES groups (−0.13 ± 0.14). Compared with the pre-test, post-test refractive error by spherical equivalent in VT-FFR-ES group for the 4-week intervention was significantly (<0.001) improved (0.21 D) compared with the control group (−0.1 D). Conclusions. The multicomponent physiotherapeutic intervention of 3D-based VT with auditory FFR and bilateral orbital ES can inhibit the progression of myopia. This intervention can be used as a noninvasive physiotherapeutic approach to prevent or reduce the severity of myopia.