bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Major Neurocognitive Disorder in Patients Admitted with Hip Fractures and the Associated Postoperative Delirium and Other Surgical Outcomes - A Prospective Cohort Study (Hippod Study)
Authors: Yuen Tammy KW , Chu Mandy HM , Liu Sally KY , Chan Iris PF , Leung Frank SN
Published: January 2023

Introduction: Major Neurocognitive disorder (NCD) and hip fractures are two serious problems in aging population. They are associated with morbidities including postoperative delirium (POD). We aimed to look at the prevalence of major NCD in hip fractures in our locality and their association with POD. Methods: It was a prospective cohort study. Patients ≥ 65 years old with hip fractures communicable in Cantonese were included. They were screened with Hong Kong Montreal Cognitive Assessment 5-min protocol before operation. They were reviewed postoperatively with 3-Minute Diagnostic Interview for Confusion Assessment Method to assess the presence of POD. The primary outcome was the incidence of delirium between patients with or without preoperative major NCD. Secondary outcomes including surgical outcomes and length of hospital stay were investigated. Results: The study was conducted between November 2020 and March 2021. One hundred ninety-two patients were screened, and 122 patients were included. Among the 192 patients screened, 97 (50.5%) were found to have major NCD. POD was found in 68.1% and 21.3% of patients with or without major NCD respectively. (p<0.001, odds ratio 4.857 (95% CI 2.046-11.531)). Total length of stay in hospital was longer when POD developed (p<0.05). Conclusion: High prevalence of major NCD was found in geriatric hip fracture patients. Pre-existing major NCD was an independent risk factor in developing POD. Both major NCD and POD were prevalent but not sufficiently addressed in our locality. A multidisciplinary collaboration between anesthetists, geriatricians and allied health workers may help to prevent POD and reduce its severity.
Precancerous Lesions of Cervix in The Lekoumou and Niari Departments (Congo Brazzaville)
Authors: FS Ngatali Christian , AF Bolenga Liboko , Y Mabiala , RA Doukaga Moussavou , D Moukassa , JB Nkoua Mbon
Published: January 2023

Objective: To determine the prevalence of precancerous lesions in the Lekoumou and Niari departments. Patients and Methods: this was a descriptive and cross-sectional study over a period of 7 months from January to July 2020 in the department of of lekoumou, The analyzes were made in the Laboratory of Medical and Morphological Analysis of the General Hospital of Loandjili. Our study involved a population of 100 women ranging in age from 16 to 73 years old. All of these women voluntarily benefited from a cervico-uterine sample. The cytological study was based on the international classification of BETHESDA 2001, taking into account the quality of the sample and the cell morphology. The variables studied were: age, marital status, level of education, cytology. Bivariate analyze was done between age and cytology. All the results of this study were statistically analyzed from the Chi-square test or Fisher's exact test using Epi-InfoTM software version 7.1.1.14, USA (http:// www.epiinfo.com). Results: The mean age of the patients was 34.6 ± 11.9 with extremes ranging from 16 to 73 years. The most represented age groups were 20-29 years old (31%) and 30-39 years old (29%). Our study population was predominantly college, accounting for 53% of cases. The proportion of uneducated women represented 11% of our study population. Almost 3⁄4 of our study population were married women (74%). Singles represented only 22% of the study population. More than half of our study population, 58%, had normal cytology. Benign and reactive cell changes were diagnosed in 20% of cases. Low-grade and high-grade precancerous lesions were observed in 8% and 12% of cases, respectively. High-grade intraepithelial lesions were more represented in patients aged between 27 and 36 years 50%, high-grade lesions represented in 47% of cases. there were no statistically significant result between age and cytology. Conclusion: prevalence of precancerous lesions is relatively high It is well known that intraepithelial neoplasia precedes invasive carcinoma after a period of about 10 years. knowledge of these precancerous lesions is necessary for optimal prevention of cervical cancer.
Unique Clinical and Pathologic Characteristics of Poorly Differentiated Primary Pleuro-Pulmonary Synovial Sarcoma
Authors: Hartel Paul H , Parker John E
Published: January 2023

Primary pleuro-pulmonary synovial sarcoma is rare and poses a diagnostic challenge particularly when poorly differentiated. We present 15 cases of poorly differentiated primary pleuro-pulmonary synovial sarcoma and compare and contrast results with previously published series on usual better differentiated tumors. Clinical and radiologic findings were similar to usual pulmonary synovial sarcoma with typical imaging features. 7 of 10 patients with outcome data died of disease within 5 years. Histologically, tumors had densely cellular fascicles, hyalinized stroma, hemangiopericytoma-like vasculature, and focal myxoid change. Round cell and rare rhabdoid morphology were unique to poorly differentiated tumors. Immunohistochemistry demonstrated at least focal expression of pancytokeratin, EMA, CK7, CK5/6, calretinin, and CD56, and diffuse positivity with CD99 and bcl-2. Ten primary pulmonary synovial sarcomas with tissue available for study were positive for t(x;18), with a more even distribution of SS18/SSX1 and SS18/SSX2 tumors compared with better differentiated lung synovial sarcomas. In conclusion, our study confirms that clinical, histological, and immunohistochemical data from poorly differentiated primary pleuro-pulmonary synovial sarcoma is similar to better differentiated tumours but special caveats remain for accurate histopathologic diagnosis.
Prevalence of the Parasite Toxoplasma Gondii in Autistic Children in Iraq
Authors: Bazzaz Ayoub A , Jameel Joan M
Published: January 2023

Background: Toxoplasmosis is a parasitic disease that can infect almost any mammalian species, if not all where one-third of the population might be infected with latent toxoplasmosis. Toxoplasmosis is more common in underdeveloped countries than developed countries where it infects a large number of people worldwide. The Toxoplasma gondii should be considered as a contributing factor in mentally ill people who have been exposed to the parasite. Toxoplasmosis primarily affects the central nervous system, putting some people at risk, more than others. The Toxoplasma gondii infection has also been linked with psychiatric illnesses; however, research on the causal pathway is limited and therefore not clearly developed. The objectives: of this humble research has been to discuss the link between Toxoplasmosis and childhood autism as a type of mental disorders. Materials and Methods: Thirty autistic children were selected from the Children’s hospital of Kerkuk city compared to fifteen healthy children used as control for comparison. Results: Using rapid-test (IgG, IgM) of Toxoplasma gondii the prevalence of anti-T. gondii IgG in autistic children were 13.3% which was significantly (p≤0.01) higher than that in healthy children (6.67%). Conclusion: It is recommended that mothers should avoid contamination of their young babies from any source of the parasites natural or artificial feeding, which might be the main pathway of infection.
Prevalence of Diabetes Mellitus among Tuberculosis patients in Bangladesh
Authors: Mamun Abdullah Al , Maqbool Adil , Sohael Farzana , Rahman Arifur , Islam Majedul , Shima Takeru , Shimojo Nobutake , Kawano Satoru , Yamaguchi Naoto , Moroi Masao , Jesmin Subrina
Published: January 2023

Aim: Tuberculosis (TB) and diabetes mellitus continue to be significant public health problems. Diabetes screening of tuberculosis patients will provide early case diagnosis, improved diabetes control, and improved tuberculosis treatment result. The purpose of this study was to ascertain the prevalence and risk factors for diabetes in tuberculosis patients, as well as their influence on the treatment result of tuberculosis. Methods: This cross-sectional study was conducted at Bangladesh's randomly chosen peripheral health institutions. All TB patients above the age of 18 years were checked for diabetes. Age, gender, family history, smoking, and BMI were all considered as risk factors. Results: Out of 165 participants, diabetes was shown to be prevalent in 35% of TB patients. Diabetes was related to advanced age and type of tuberculosis; its origin (pulmonary or extra pulmonary) and socioeconomic level were found to be significant. Conclusion: Diabetes is a common comorbidity among tuberculosis patients. Over the age of 50 years, the risk of this twin morbidity increases significantly. Screening tuberculosis patients for fasting blood sugar values will aid in the early diagnosis of diabetes and will lead to a better prognosis.
Evaluation of Diabetes Mellitus in Diabetic Patients in a Correlation Between Body Mass Index and Blood Sugar
Authors: Abadi Tabarak Sh , Ibrahim Maryam T , Ahmed Aydin S , Tahir Pinar H
Published: January 2023

Background: Body mass index (BMI) criteria are currently the primary focus in obesity treatment recommendations, with different treatment cutoff points based upon the presence or absence of obesity-related comorbid disease. Aim: This project aimed to explore the relationship of body mass index with blood sugar. Patients & methods: Seventy-one adult diabetic patients (36 males+35 females) were subjected to this study. Body mass index was calculated for each patient and random blood sugar was also measured. Results: The highest mean value of BMI was among male & female patients in the age group 60-69 years old, which reached 36.57 & 32.74, respectively while the mean value of random blood sugar in males was among the age group 30-39 years which reached 258.88 mg/dL. But it was 295.0mg/dL among age group >70years in females. Conclusion: It is concluded that obesity is an important risk factor for diabetes and there was a relationship between BMI and increased blood sugar
STUDENTS' REFLECTIVE ABSTRACTION LEVEL IN SOLVING MATHEMATICS PROBLEMS BASED ON COGNITIVE STYLES FIELD INDEPENDENT (FI) AND FIELD INDEPENDENT (FD)
Authors: Yanti Aning Wida , Arrifadah Yuni , Mustikarini Adelia Ayu
Published: January 2023

Reflective abstraction is an activity to construct mathematical concepts through similarities and combinations of existing structures and reorganized into four levels: (1) recognition, (2) representation, (3) structural abstraction, and (4) structural awareness. Each individual has different characteristics of cognitive style in processing information. Differences in cognitive style affect the individual's ability to understand the problem. This study aims to describe students' level of reflective abstraction in solving mathematical problems in terms of field-independent (FI) and field-dependent (FD) cognitive styles. This research is a qualitative descriptive study. Task-based interviews carried out the data collection technique. The results are that field-independent (FI) students can correctly perform all levels of reflective abstraction in the stages of solving mathematical problems, but field-dependent (FD) students can only do abstraction on the introduction and representation.
THE INFLUENCE OF PARENTAL GUIDANCE AND LEARNING MOTIVATION ON STUDENT MATHEMATICS LEARNING OUTCOMES BASED ON STUDENT EMOTIONAL INTELLIGENCE
Authors: Prajitno Sunyoto Hadi , Aulia Tania Ismi
Published: January 2023

The emotional intelligence of students is an essential aspect in achieving learning results, particularly in mathematics. This study intends to identify the impact of parental supervision and learning motivation on mathematics learning outcomes at Wahid Hasyim 8 Waru Middle School in terms of high, medium, and low emotional intelligence. This research utilizes quantitative research methods by doing ex-post facto. In collecting data, the researcher uses surveys and documentation. The questionnaire instrument contains three questionnaires, including a parent guidance questionnaire, a learning motivation questionnaire, and an emotional intelligence assessment. While documentation is used to collect statistics on student learning outcomes, it also serves as a means of communication between instructors and students. The results of hypothesis testing from the results of parental guidance and learning motivation on student learning outcomes are reviewed in terms of high emotional intelligence with an F count of 40,661 and an F sig of 0.024, moderate emotional intelligence with an F value of 5.288, and an F count of 0.010, and emotional intelligence with an F value of 7.073 and an F sig of 0.049. The association between mathematical learning results, parental supervision, and learning motivation in terms of emotional intelligence might be described as good and significant.
Kepemimpinan Kepala Sekolah Dalam Lembaga Pendidikan di MI Ma’arif NU Karangsari
Authors: Nisa Dewi Rofikotun , Indrayanti Salma , Sukataman Sukataman , Nurhakim Imam
Published: January 2023

Education is the quality of a school that requires professional education personnel. Education personnel play an active role in shaping the knowledge and skills of students. Because the education staff will produce higher quality graduates. One way to realize this professionalism requires one of the supports from the principal. The principal is very important in leading those who are directly related to the implementation of educational programs in schools. The approach used in the research at MI Ma'arif NU Karangsari is a qualitative approach, data collection techniques through observation and interviews. The purpose of this paper is to determine the leadership role of school principals in developing institutions and principals' strategies in developing educational institutions. The principal of the MI Ma'arif NU Karangsari school was able to improve the development of existing institutions at the school. This is evident from the curriculum, student affairs, facilities and infrastructure and student learning achievement that goes well and according to teacher performance standards.
ANALISIS RISIKO PELAYANAN PASIEN LAMA TERHADAP PENYAKIT DIABETES MELITUS TIPE 2 (STUDI KASUS : RS YADIKA PONDOK BAMBU JAKARTA TIMUR)
Authors: Silaen Jeffry Albert , Indra Gunawan  , Tewu M.L.Denny
Published: January 2023

ABSTRAK
Manajemen Risiko merupakan aktivitas manajemen didalam mempersiapkan strategi untuk merespon risiko atau kejadian yang tidak diinginkan muncul. RS Yadika Pondok Bambu dalam menjalankan kegiatan bisnis pelayanan Rumah sakit akan melewati tahapan didalam proses bisnis pelayanan Rumah sakit yaitu pendaftaran, pemeriksaan Pasien di ruang tunggu poliklinik Penyakit dalam,ketidakmampuan mendiagnosa pasien DM Type 2 dan Terapi. Penelitian ini menggunakan tahapan manajemen risiko yang dimulai dari Identifikas risiko disetiap tahapan proses bisnis penjualan perumahan dengan menggunakan diagram fishbone didapati ada 10 item risiko dari setiap tahapan yang terbagi dari 2 item risiko di tahapan pendaftaran, 3 item pemeriksaan Pasien di ruang tunggu poli Penyakit dalam, 2 item risiko ketidakmampuan mendiagnosa pasien DM Type 2 dan 3 item risiko di Terapi.
Kemudian dilanjutkan dengan mengukur risiko dengan menghitung peluang dan dampak dari risiko tersebut dan dengan tabel Heat Map hasil perkalian antara peluang dan dampak dari risiko - risiko di setiap tahapan proses bisnis pelayanan Rumah Sakit diketahui bahwa nilai Risk Assesment Matrik berada dalam kategori tinggi dan sangat tinggi. Dan diakhiri dengan menggunakan diagram Treshold of Risk Level diketahui tekhnik pengelolaan risiko yaitu dengan Avoidance atau menghindari risiko tersebut yang dipergunakan merancang strategi untuk merespon risiko. Dan dari penelitian ini diperoleh strategi respon risiko untuk tahapan pendaftaran adalah sebelum melakukan pelayanan kepada pasien, Rumah sakit harus terlebih dahulu melakukan survey secara langsung dan teliti, komunikasi dan koordinasi dengan semua pihak pelayanan medis, penunjang medik, medical record dan Apoteker serta sosialisasi secara resmi serta transparan informasi sesuai prosedur yang berlaku kepada semua dokter Spesialis penyakit dalam dan pihak lain.
Tahapan kedua yaitu pemeriksaan Pasien di ruang tunggu poliklinik Penyakit dalam dengan strategi respon risiko adalah mengkaji ulangruang tunggu yang sesuai dengan standart yang berlaku, pemeriksaan dasar yang sesuai dan ruang periksa yang sesuai dengan standar yang berlaku. Strategi Respon risiko tahapan keidakmampuan mendiagnosa penyakit DM type 2 adalah koordinasi dengan pihak dokter spesialis penyakit dalam agar memeriksa pasien sesuai dengan standar operasional prosedur (SOP) yang berlaku serta koordinasi dengan kepala penunjang medic untuk menyediakan pemeriksaan penunjang. Dan untuk tahapan terapi respon risikonya adalah perlu koordinasi antara apoteker dengan dokter spesialis penyakit dalam serta pasien dalam menyedikan terapi yang dibutuhkan.Kata kunci : manajemen risiko, proses bisnis, strategi respon risiko
STUDI MANAJEMEN RISIKO AKAD MURABAHAH PADA PERBANKAN SYARIAH
Authors: Ahmad Suhaimi
Published: January 2023

abstract

no abstract
ANALISIS RISIKO DISPUTE KLAIM COVID TERHADAP OPERASIONAL CASHFLOW DI RS. JT
Authors: Ariditya Pramesti  , Poerwaningsih S. Legowo  , Martua E.Tambunan
Published: January 2023

Abstrak
Dispute klaim pada klaim Covid yang diajukan oleh rumah sakit menyebabkan gangguan pada operasional cashflow RS. JT. Berdasarkan data rumah sakit pada bulan Maret - Desember 2021, klaim Covid-19 yang dinyatakan dispute di beberapa bulan pengajuan ada yang mencapai sampai diatas 50%. Penelitian ini dilakukan untuk mengidentifikasikan penyebab dispute klaim tersebut dan risiko dari tiap penyebab klaim dispute serta menentukan mitigasi atas risiko penyebab klaim dispute. Metode pengumpulan data dilaksanakan melalui survei dengan angket dan wawancara. Dalam menentukan sumber informasi, melibatkan 20 tenaga rumah sakit yaitu pada unit Casemix , unit Keuangan, unit Farmasi, unit Laboratorium, dan juga dokter spesialis. Hasil penelitian menunjukan bahwa dalam analisis penyebab dispute klaim yaitu Man, Environment, Method, Material dan Communication. Dalam analisis tersebut terdapat 24 risiko dari penyebab klaim dispute. Terdapat 7 risiko masuk dalam kategori Issue, 12 risiko masuk dalam Supplementary Issue dan 5 risiko masuk dalam kategori Acceptable. 7 risiko tertinggi yang masuk dalam kategori Issue yaitu: “Seluruh stake holder rumah sakit tidak memahami akibat dispute klaim”, “Pelayanan yang diberikan petugas tidak optimal karena kebutuhan operasional tidak dapat terpenuhi”, “Seluruh stake holder rumah sakit tidak memahami cara dan ketentuan pengisian formular Penilaian Epidemiologi (PE)”, “ Tidak lengkapnya pengisian form PE pasien sangat mengganggu proses administrasi klaim”,”Medical Record manual sering menghambat proses pengklaiman”,”Tidak bridgingnya SIMRS dan INACBGS mempengaruhi proses pengklaiman” dan “Dinkes Provinsi dan Dinas Kesehatan Kota Bekasi serta BPJS tidak berkoordinasi dengan baik”. Risiko yang masuk dalam kategori Issue dan Supplementary Issue harus segera ditangani sebagai usaha memperkecil risiko yang terjadi di rumah sakit.
Kata kunci: Dispute Klaim, Risiko, RS. JT.
Mengukur Risiko Kredit dengan Model Merton
Authors: Tarsicius Sunaryo
Published: January 2023

Abstract:
Nilai perusahaan sama dengan penjumlahan nilai saham dan nilai utang (bond atau kewajiban) perusahaan. Nilai perusahaan berfluktuasi. Bila nilai perusahaan lebih kecil dibanding nilai bond perusahaan, maka perusahaan default. KMV menentukan bahwa titik default perusahaan sama dengan nilai utang jangka pendek dan setengah dari utang jangka panjangnya. Semakin tinggi nilai perusahaan, semakin kecil perusahaan default. KMV memetakan jarak dari nilai perusahaan ke titik default ke frekuensi default (expected default frequency).

Keywords: risk/credit sensitive bond,leverage, probaility of default, default point, distane to default, mapping, expeced default frequencies, credit loss, expected credit loss, credit put, credit derivative.
Alcoholic Liver Disease: A Comprehensive Review
Authors: Pal Partha , Ray Sayantan
Published: January 2023

Alcoholic liver disease, a leading cause of morbidity, mortality, and cirrhosis, can range from simple steatosis to hepatocellular carcinoma. Multiple mechanisms such as oxidative stress, mitochondrial dysfunction, and alteration in gut-liver axis have been proposed for the pathogenesis of alcoholic liver disease. Based on different prognostic models, alcoholic hepatitis patients can be stratified into sub-groups and specific pharmacological therapy can be started. Alcohol abstinence has a clear cut mortality benefit and nutritional support is very important as most of the patients are malnourished and in a hypercatabolic state. Other than conventional glucocorticoids and pentoxifylline, newer agents and combination therapy can be used in severe alcoholic hepatitis in patients not responsive to conventional glucocorticoid therapy. Liver transplantation improves survival in advanced alcoholic cirrhosis and it can be an option in severe alcoholic hepatitis patients who are not responding to other medical therapies. Whether early transplantation can improve the survival compared with the conventional waiting period of 6 months is an active area of investigation. This is due to the fact that most of the disease-related mortality occurs in the first 2 months.
Boosting Cancer Immunotherapies with Optical Biosensor Nanotechnologies
Authors: Soler Maria , Lechuga Laura M.
Published: January 2023

An increasing number of cancer patients have found new hope in the form of recently discovered cell immunotherapies. These novel treatments empower our own immune system to fight and eradicate the malignant tumours, even in metastatic stages. Unprecedented outcomes have been demonstrated with bioengineered cells especially modified in laboratories to trigger a highly specific and active anti-tumour function; however, a main bottleneck for the implementation of these promising therapies resides in the old-fashioned and limited techniques employed for the in vitroanalysis and study of cells during manufacturing and testing processes. Optical label-free biosensors are currently arising as promising analytical technologies for a simplified and accurate cell analysis. In particular, biosensors based on evanescent field principles enable direct, non-invasive, and real-time monitoring of biological events, showing outstanding sensitivities and excellent robustness. Furthermore, these biosensors are easily incorporated in lab-on-a-chip platforms for simple operation and implementation in clinical laboratories. In this review, the authors present and discuss the more recent research aimed to develop label-free optical biosensors for the analysis of live cells and the direct benefits offered to cell immunotherapy production allowing for its widespread implementation.
Novel Anticoagulants in Atrial Fibrillation
Authors: McEvoy Lynda
Published: January 2023

This educational seminar, supported by an independent educational grant from Daiichi Sankyo, was held at the AHA congress in Dallas on 19th November 2013. The meeting provided clinicians with an update on the pharmacokinetics and pharmacodynamics of new anticoagulant drugs. The speakers also discussed how best to use these agents according to the latest evidence.
Skin pH in the Elderly and Appropriate Skin Care
Authors: Schreml Stephan , Kemper Michael , Abels Christoph
Published: January 2023

The acidic skin surface pH (pHSS) plays a crucial role in the maintenance of a vital stratum corneum (SC) and an intact epidermal barrier. However, ageing affects the pH of the skin, both pHSS and the pH of the stratum corneum (pHSC). The purpose of this article is to review the physiological function of skin pH and the effects of an age-related increase of skin pH. Moreover, the consequences for the development of skin care products, specifically for the elderly, will be discussed. Reported pHSS values of the skin range between 4 and 6 in non-intertriginous areas. The acidity of the outer surface of the skin is essential regarding the following functions: epidermal barrier homeostasis, integrity/cohesion of the SC, support of proteolytic processes leading to desquamation, metabolism of extracellular lipids, and microbiological colonisation of the SC. Exogenous, as well as endogenous factors, affect skin pH (especially pHSS), thereby influencing its functions. Age is one important endogenous factor. Interestingly, pHSS of adults slightly increases with age. This increase of pHSSinfluences several functions in ageing skin. Increased pHSS may impair epidermal barrier permeability, integrity/cohesion of the SC, and even antimicrobial capacity. Hence, ageing skin shows an increased vulnerability, not only towards mechanical stress. Moreover, aged skin often appears rough and dry, which is sometimes associated with itching. However, so far only a few studies have investigated the effect of skin care products on ageing skin. In addition, normalising the increased skin pH in the elderly by appropriate skin care products formulated with a lower pH, e.g. 4, may improve impaired skin functions, which are impaired.
State-Of-The-Art Treatment in Castration-Resistant Prostate Cancer
Authors: Castro Elena , Romero Nuria , Olmos David
Published: January 2023

Prostate cancer (PrCa) is the most common cancer type in men in developed countries. In the last few years, a dramatic change has occurred in the understanding of castration-resistant PrCa which has led to the development of new drugs that have an impact on patient survival. This review summarises the recent advances in the management of the disease.
Genomic Testing in International Guidelines
Authors: Kern Peter , Rezai Mahdi , Singer Christian , Kimmig Rainer
Published: January 2023

Human breast cancer was solely classified based on clinical and immunohistochemical (IHC) findings in the past. A growing body of evidence suggests that these categorisations are rendered more precisely by intrinsic subtyping with the aim of an introduction of personalised medicine. Especially in breast cancer with the uncertain potential of disease spread, such as T1-2, Grade 2 and oestrogen receptor-positive (ER+ve) tumours, the value of chemotherapy applied to every patient has been questioned and the need for additional information on the tumour´s specific risk of recurrence is overt. It is estimated that the average risk for recurrence is 15% at 10 years in hormone-receptor-positive breast cancer. Thus, a relatively small proportion of these patients would need chemotherapy, and the main task is to stratify which patients of this cohort are at high-risk and will benefit from cytotoxic agents. Ki67, as a proliferation marker classifying high-risk tumours, has been demonstrated as a continuous marker, but not as a clear cut risk-defining instrument in recent publications. Thus, the difficulties are perceived especially at the threshold of the low to high-risk area of this marker. Reproducibility of Ki67 is to some extent uncertain considering there is inter and intra-institutional variability of up to 30% of the results. Several multigene arrays, such as MammaPrint®, Oncotype DX®, Endopredict®, and PAM50 have demonstrated clinical utility and experienced validation. The aim of this review is the description of the implementation of genomic testing in international guidelines (North American and European), with regard to incorporation of multigene arrays into the decision-making process in different clinical settings (including tumour size and IHC status). Data cut-off was 1st October, 2013. It seems that North America and some European countries have initiated a shift towards a personalised medicine with multigene arrays based on RT-PCR or microarrays.
The Delirium of Rationalism: Why Deleuze Invokes Spinoza and Leibniz
Authors: Vermeiren Florian
Published: January 2023

Why does Deleuze rely so heavily on Spinoza and Leibniz? At first glance, his critique of representation and the traditional ‘image of thought’ seems to oppose him to rationalism. However, Deleuze says that when the ‘cry of rationalism’ is pursued until the end, rationalism becomes ‘delirious’. In such a state, it undermines the model of representation. This delirium is found in Spinoza and Leibniz's critique of generality and their conflation of essence and existence, through which they ruin the traditional mediation of difference by identity and generality. However, for this rationalism to completely break with representationalism it must undergo some Deleuzian corrections.
IMPLEMENTASI PENGELOLAAN PAJAK BUMI DAN BANGUNAN PERKOTAAN PEDESAAN (PBB-P2) DI KABUPATEN BANDUNG PROVINSI JAWA BARAT
Authors: Elsye Rosmery
Published: January 2023

Penelitian ini bertujuan untuk mengetahui sejauh mana implementasi pengelolaan PBB-P2 di Kabupaten Bandung pasca diberlakukannya Undang-Undang 28 Tahun 2009 tentang Pajak dan Retribusi Daerah. Penelitian ini menggunakan metode kualitatif dengan analisis diskriptif. Data diperoleh dari data primer dari lapangan dan data sekunder dari Bapenda Kabupaten Bandung. Hasil dan simpulan dari penelitian ini menunjukan bahwa pengelolaan pajak PBB-P2 di Kabupaten Bandung telah dilakukan dengan merujuk kepada Undang-Undang 28 Tahun 2009 dan pedoman pengelolaan pajak yang dikeluarkan oleh Ditjen Pajak Kementerian Keuangan. Rujukan lainnya yang digunakan adalah Peraturan Bupati nomor 69 Tahun 2016 tentang pengelolaan PBB-P2 di Kabupaten Bandung. Hasil yang diperoleh adalah secara kuantitatif penerimaan PBB-P2 setiap tahunnya mengalami kenaikan. Dinas Pendapatan Daerah hingga saat ini diberi wewenang dan tanggung jawab pengelolaan pajak dalam rangka memaksimalkan penerimaan pajak. Kondisi lapangan saat ini dikarenakan wilayah Kabupaten sangat luas, maka dibentuk dan ditetapkan UPTD-UPTD pelayanan pajak. UPTD ini mempunyai tanggungjawab untuk menjadi perpanjangan Dispenda. Dalam implementasinya, setiap UPTD melayani 6 (enam) sampai 7 (tujuh) wilayah kecamatan terdekat. Hal ini guna memberikan kemudahan bagi masyarakat yang akan melakukan pembayaran pajak daerah. Selain itu, adanya pelayanan pajak dengan menggunakan mobil keliling, dapat efektif dalam memberikan pelayanan publik dalam menjangkau pelayanan kepada masyarakat. Sehingga masyarakat merasakan puas atas apa yang dilakukan oleh Dinas Pendapatan Daerah Kabupaten Bandung.

Kata kunci: Pengelolaan; PBB-P2; dan UU 28/2009.
Dampak Bencana Alam Terhadap Perekonomian Masyarakat di Kabupaten Tanah Datar
Authors: Utomo Decky Dwi , Marta Fitri Yul Dewi
Published: January 2023

Bencana alam memiliki banyak dampak negatif diantaranya kerusakan infrastruktur, wabah penyakit, permasalahan sosial dan ekonomi. Penelitian ini dilatarbelakangi karena adanya kerentanan kondisi ekonomi masyarakat terhadap bencana di wilayah Tanah Datar. Penelitian ini bertujuan untuk mengkaji kerentanan ekonomi masyarakat melalui pemodelan untuk menganalisis tingkat kerentanan masyarakat dengan menganalisis data dokumen kajian risiko bencana kabupaten Tanah Datar. Penelitian ini menggunakan kualitatif melalui pendekatan deskriptif analitis. Berdasarkan hasil penelitian ini disimpulkan bahwa tersimpan beragam potensi bencana di Kabupaten Tanah Datar. Potensi bencana dilihat berdasarkan kejadian bencana yang pernah terjadi dan kemungkinan kejadian bencana lainnya, bencana juga dapat menghentikan laju perekonomian terutama bagi para korban meskipun bersifat sementara terutama yang dampak kerugiannya signifikan mencapai angka triliunan rupiah, contohnya adalah uang yang seharusnya digunakan sebagai pembangunan digunakan untuk membantu para korban bencana yang telah kehilangan harta benda sehingga pemerintah baik daerah maupun pusat harus mengeluarkan dana APBN/ APBD yang cukup besar untuk mengganti kerugian tersebut.
Pelayanan KTP-el Melalui Aplikasi Whatsapp Di Dinas Kependudukan Dan Pencatatan Sipil Kabupaten Fakfak
Authors: Melani Ika , Lareken Muhammad Syafei Endro
Published: January 2023

Pelayanan Kartu Tanda Penduduk Elektronik melalui aplikasi whatsapp merupakan kebijakan dari pemerintah Kabupaten Fakfak untuk mencegah penyebaran virus corona/covid-19. Melalui pelayanan menggunakan aplikasi whatsapp ini tentunya masyarakat dan pegawai selalu terjaga dari berkerumun dan masyarakat juga diberi kemudahan untuk tetap tinggal di rumah walaupun ingin mengurus dokumen kependudukan seperti, Akta Kematian, Akta Kelahiran, Kartu Tanda Penduduk, Kartu Identitas Anak, dan surat pindah. Penelitian ini dilakukan untuk melihat dan mengetahui bagaimana pelayanan KTP-el melalui aplikasi whatsapp, apa yang menjadi faktor penghambat, dan apa saja upaya Dinas Kependudukan dan Pencatatan Sipil Kabupaten Fakfak untuk mengatasi hal-hal yang menjadi hambatan dalam pelayanan KTP-el melalui aplikasi whatsapp. Berdasarkan hasil penelitian, penulis menyimpulkan bahwa Pelayanan KTP-el melalui aplikasi whatsapp di Dinas Kependudukan dan Pencatatan Sipil Kabupaten Fakfak untuk dapat mengurangi faktor penghambat dengan melakukan upaya-upaya seperti melakukan sosialisasi baik mengenai manfaat dokumen kependudukan, maupun sosialisi tentang pelayanan KTP-el melalui aplikasi whatsapp, pengembangan dan pelatihan terhadap semua pegawai agar dapat mengoperasikan semua pelayanan penerbitan dokumen kependudukan.
Strategi Dinas Pariwisata dalam Mempromosikan Wisata Daerah pada Masa Pasca Pandemi Covid-19 di Kabupaten Pacitan
Authors: Oktafiantika Wulan , Triono Bambang , DJ Ekapti Wahjuni
Published: January 2023

Wisata merupakan kebutuhan tersier. Seseorang akan melakukan wisata apabila semua kebutuhan pokok dan sekundernya terpenuhi. Setelah berjalannya pandemi covid-19 selama kurang lebih dua tahun yaitu pada awal tahun 2020 hingga akhir 2021 menyisakan banyak trauma yang mendalam bagi kehidupan manusia. Dari permasalahan tersebut peneliti mengambil tiga rumusan masalah yaitu bagaimana strategi Dinas Pariwisata dalam mempromosikan wisata daerah pada masa pasca pandemi Covid-19 di Kabupaten Pacitan, faktor penghambat strategi Dinas Pariwisata dalam mempromosikan wisata daerah pada masa pasca pandemi Covid-19 di Kabupaten Pacitan dan bagaimana solusi yang dilakukan oleh Dinas Pariwisata dari faktor yang menjadikan penghambat promosi. Tujuan dari penelitian ini yaitu untuk mendeskripsikan bagaimana upaya yang dilakukan Dinas Pariwisata dalam mengembangkan wisata setelah pandemi Covid-19. Hasil dari pembahasan bahwa strategi dinas pariwisata dalam mempromosikan wisata daerah yaitu dengan menggunakan ke empat strategi sesuai yang sudah dipaparkan dalam teori yaitu periklanan, promosi, publisitas dan penjualan pribadi. Faktor penghambat strategi Dinas Pariwisata dalam mempromosikan wisata daerah pada masa pasca pandemi Covid-19 di Kabupaten Pacitan yaitu faktor internal dan eksternal. Faktor internal berupa kurangnya Sumber Daya Manusia kepengurusan dan faktor eksternal karena adanya pembatasan terkait jumlah pengunjung wisata. Solusi yang dilakukan oleh Dinas Pariwisata dari faktor yang menjadikan penghambat promosi yaitu dinas pariwisata dalam melakukan promosi wisata dinas pariwisata mengadakan rapat evaluasi disetiap bulan, selain itu juga mengadakan kegiatan pelatihan-pelatihan tentang pengelolaan wisata dan juga pelatihan promosi wisata dengan tujuan memunculkan ide-ide kreatif untuk menarik simpati pengunjung wisata.
DAS MARGENS AO CENTRO: ARTE DRAG EM EXPANSÃO
Authors: Cardoso Allan , Pazetto Debora
Published: January 2023

Este ensaio consiste em uma investigação das práticas drag enquanto linguagem artística e suas relações com as teorias queer/cuír e as técnicas e métodos de exposição das artes visuais. Para tal, a primeira parte investiga brevemente as possíveis origens da arte drag no mundo ocidental, seu desenvolvimento ao longo da história e sua configuração atual. Articula-se com suas poucas aparições ou sugestões na história da arte euroamericana e com alguns apontamentos dos estudos queer/cuír, para então tecer suas proximidades e disparidades com a concepção de performance nas artes visuais. Na segunda parte, a persona drag de uma das autoras, Eco Zazu, relata seu próprio processo de tornar-se drag e suas investigações nas artes visuais.
O Fashion Film como uma ferramenta de divulgação da moda agênero
Authors: Ferreira Ceiça , Quege de Moraes Jade
Published: January 2023

O presente artigo propõe investigar como a moda reproduz as convenções sociais, mas também tem possibilitado a emergência do conceito agênero e dá continuidade à produção de fashion films como estratégia de divulgação, agora direcionada para as redes sociais. Metodologicamente, ancoramo-nos em revisão bibliográfica e em um breve levantamento de marcas (nacionais e estrangeiras), que defendem esse posicionamento. Partimos da hipótese de que a articulação entre moda e publicidade audiovisual pode criar diferenciadas representações , ampliando assim também as formas de relacionamento com o público. A partir da análise descritiva de campanhas publicitárias e perfis dessas marcas no Instagram, foi constatado que, embora a moda agênero mostre-se capaz de apresentar a pluralidade de corpos e subjetividades, seus fluxos e deslocamentos, as marcas estudadas demonstram que, na prática, esse conceito ainda se concentra em grandes cidades, destaca corpos magros e jovens e geralmente é direcionada para consumidores de classe média/alta.
A IMPOSSIBILIDADE DA ‘ARTE COMO TAL’ NA FRONTEIRA DECOLONIAL
Authors: Méndez Maria del Rosario Tatiana Fernández
Published: January 2023

Este artigo explora os espaços de impossibilidade da arte na fronteira decolonial, como espaços que tem potência poética. Nesse processo analisa o discurso universalista e individualista da estética moderna ocidental repleto de possibilidades que são ao mesmo tempo impossibilidades no contexto das relações entre arte moderna e regimes coloniais. Para fazer visíveis as contradições do discurso e a impossibilidade da arte como lugar de potência estética e poética parte-se da diferenciação de arte como tal de Stephen Wright, da perspectiva descolonizadora de ch'ixi, ou manchado, de Silvia Rivera Cusicanqui e double bind, ou convivência dos contrários, de Gayatri Spivak onde os espaços de impossibilidade da arte colocam em evidência as relações coloniais. Nessas bases observam-se indícios da chamada polícia da arte, de Jacques Rancière, nos casos da arte naive haitiana e arte aborígene australiana. A análise revela evidências da potência estética e poética de espaços onde a arte como tal é impossível e ao mesmo tempo questiona a universalidade da matriz ocidental como uma imposição colonial.
Early childhood learning analytics: A case study of Learning Jungle
Authors: Liang Rui , Zhu Hongmei , Lawson Grant , Lian Zhao , Huang Yuqi , Chen Shengyuan
Published: January 2023

The benefits of participating in high-quality Early Childhood Education (ECE) have been recognized by people for many years; and the need for high-quality ECE has never been greater. In this case study, we focus on whether ECE can improve learning speed in five domains: social, emotional, communication, cognition, and physical development. The initial ages for each of these five domains, in months since birth, are collected and compared with that of common children as described in Nipissing District Developmental Screen (NDDS). We find that children in the ECE program learned faster with a p-value no >0.0078. In addition, students in an ECE program are labeled by their ages at enrollment as Cohort 1 (infant) and Cohort 2 (toddler), and we conduct the following statistical tests on their difference: Welch's t-test, Hoteling's T2-test, and survival analysis. We find that the average initial observation age of Cohort 1 is 4.82 months earlier than that of Cohort 2 with a p-value no >0.009. We are convinced that ECE programs could advance students' learning in all five domains.
Innovation in identifying metabolites from complex metabolome—Highlights of recent analytical platforms and protocols
Authors: Qiu Shi , Guo Sifan , Yang Qiang , Xie Yiqiang , Tang Songqi , Zhang Aihua
Published: January 2023

Metabolites are closely intertwined genotypes that can provide clear information about the final phenotype. The high-throughput analysis platform used to identify candidate metabolites and describe their contributions can help to quickly detect metabolic characteristics from large spectral data, which may lead to peak data preprocessing, statistical analysis and functional interpretation. Developing a comprehensive strategy for discovering and verifying bioactive metabolites can provide a large number of new functional biomarkers, and then more closely reveal their functional changes, which has relevant biological significance for disease diagnosis and prognosis treatment.
Follow-up value of serum AFP and aminotransferases in chronic hepatitis B progression
Authors: Yu Mengyao , Huang Lei , Zhang Shichang , Jiang Longfeng , Jin Yuexinzi , Gu Min , Liao Jun , Zhang Jiexin
Published: January 2023

Introduction

Chronic viral hepatitis (CH) is a stage prior to cirrhosis and primary cancer. Standard protocols for CH assessment during the long follow-up period are of great importance for precise treatment and living quality improvement. In this study, we aimed to analyze multiple serum indexes in chronic hepatitis B (CHB)-infected patients and to discuss their combined values in clinical applications.

Methods

Total 503 lines of laboratory data from 2012 to 2021 were extracted from103 CHB patients who were followed-up in our hospital. They were divided into the remission group and the progression group according to their complete clinical information and laboratory data. A series of models of serum indexes were analyzed to illustrate the fluctuation trend of @ach index in a time-dependent manner.

Results

The models revealed that abundant serum alpha-fetoprotein (AFP) in the remission group was characteristically associated with hepatocyte destruction markers aspartate aminotransferase (AST) and alanine aminotransferase and favored a much longer progression-free period (P 0.0001). A model-derived equation consisting of serum AFP and AST values showed a good performance (83% reliability) to distinguish the two groups.

Discussion

This study clearly demonstrates the intrinsic quantitative relationship between serum AFP and liver aminotransferases involving antivirus treatment response. The model-based equation compensates for serum hepatitis B virus DNA detection during outpatient follow-up and it may serve as a useful laboratory tool for CHB progression assessment.
Comparison of transcatheter edge-to-edge and surgical repair in patients with functional mitral regurgitation using a meta-analytic approach
Authors: Felbel D. , Paukovitsch M. , Förg R. , Stephan T. , Mayer B. , Keßler M. , Tadic M. , Dahme T. , Rottbauer W. , Markovic S. , Schneider L.
Published: January 2023

Background

Evidence regarding favorable treatment of patients with functional mitral regurgitation (FMR) using transcatheter edge-to-edge repair (TEER) is constantly growing. However, there is only few data directly comparing TEER and surgical mitral valve repair (SMVr).

Aims

To compare baseline characteristics, short-term and 1-year outcomes in FMR patients undergoing mitral valve (MV) TEER or SMVr using a meta-analytic approach.

Methods

Systematic database search identified 1,703 studies reporting on TEER or SMVr for treatment of FMR between January 2010 and December 2020. A meta-analytic approach was used to compare outcomes from single-arm and randomized studies based on measures by means of their corresponding 95% confidence intervals (CI). Statistical significance was assumed if CIs did not overlap. A total of 21 TEER and 37 SMVr studies comprising 4,304 and 3,983 patients were included.

Results

Patients in the TEER cohort presented with higher age (72.0 ± 1.7 vs. 64.7 ± 4.7 years, p < 0.001), greater burden of comorbidities like hypertension (p < 0.001), atrial fibrillation (p < 0.001), lung disease (p < 0.001) and chronic renal disease (p = 0.005) as well as poorer left ventricular ejection fraction (30.9 ± 5.7 vs. 36.6 ± 5.3%, p < 0.001). In-hospital mortality was significantly lower with TEER [3% (95%-CI 0.02–0.03) vs. 5% (95%-CI 0.04–0.07)] and 1-year mortality did not differ significantly [18% (95%-CI 0.15–0.21) vs. 11% (0.07–0.18)]. NYHA [1.06 (95%-CI 0.87–1.26) vs. 1.15 (0.74–1.56)] and MR reduction [1.74 (95%-CI 1.52–1.97) vs. 2.08 (1.57–2.59)] were comparable between both cohorts.

Conclusion

Despite considerably higher age and comorbidity burden, in-hospital mortality was significantly lower in FMR patients treated with TEER, whereas a tendency toward increased 1-year mortality was observed in this high-risk population. In terms of functional status and MR grade reduction, comparable 1-year results were achieved.
Cardiac MRI with late gadolinium enhancement shows cardiac involvement 3–6 months after severe acute COVID-19 similar to or worse than PIMS
Authors: Chochkova-Bukova Lyubov A. , Funken Dominik , Bukova Mila , Genova Kamelia Z. , Ali Sadika , Stoencheva Snezhana , Paskaleva Ivanka N. , Halil Zeira , Neicheva Ivelina , Shishmanova Anastasia , Kelly Kristina Stefanova , Ivanov Ivan S.
Published: January 2023

Background

Coronavirus disease 2019 (COVID-19) in children is rarely severe. However, severe courses occur, especially in the presence of risk factors. A minority of children develop pediatric inflammatory multisystem syndrome (PIMS) with substantial morbidity. While the importance of cardiac involvement after PIMS is well established, its role after severe acute COVID-19 remains unclear. We aim to compare cardiac sequelae of children after severe acute COVID-19 using cardiac MRI and compare them with patients after PIMS.

Methods

For this prospective cohort study, we recruited patients with acute COVID or PIMS in a single center. Clinical follow-up, lab work, ECG, and echocardiography were done within 2 days after disease onset and 3–6 months after discharge. At the last visit 3–6 months later, cardiac MRI (CMR) with late gadolinium enhancement (LGE) was performed to evaluate cardiac sequelae and compare both groups.

Results

Data were obtained from n = 14 patients with PIMS and n = 7 patients with severe acute COVID-19. At the start of the respective disease, left ventricular (LV) ejection fraction was reduced in seven patients with PIMS but none in the acute COVID-19 group. Transient mitral valve insufficiency was present in 38% of patients, of whom PIMS accounted for 7/8 cases. Eight patients (38%) with PIMS presented coronary artery abnormalities, with normalization in 7/8 patients. A significant decrease in LV mass index 3–6 months after disease onset was observed in both groups. MRI follow-up revealed non-ischemic myocardial pattern of LGE in 12/21 patients- in all (6/6) after severe acute COVID-19 and in less than half (6/14) after PIMS. Normal body weight-adjusted stroke volumes and end-diastolic volumes were found in 20/21 patients.

Conclusions

We show that children suffering from severe acute COVID-19 have a similar, or worse, cardiac risk profile as patients with PIMS. Both patient groups should therefore receive close pediatric cardiac follow-up examinations. Cardiac MRI is the technique of choice, as most patients presented with delayed LGE as a sign of persistent cardiac injury despite normalization of laboratory and echocardiographic findings.