bluuebunny/crossref_metadata_2025 huggingface dataset:
Initial endosseous healing response to lactide/ glycolide copolymer
Authors: Dilcele Silva Moreira DZIEDZIC  , Isabella Caroline BERTOJA  , João César ZIELAK
Published: April 2023

Introduction: The search for less invasive treatments, with fast and effective bone regeneration, has lead to the development of synthetic bioresorbable alternatives for bone graft. The commercial product FisiograftTM gel (Ghimas Spa, Italy), based on lactide-glycolide copolymer, is used as an injectable biocompatible and bioresorbable material for filling bone defects in dental surgery applications. These polymers are also used in the production of suture threads, pins and plates for bone fixation, and barriers for guided tissue regeneration. Objective: The main objective of this pilot study was to observe the initial bone healing response after the application of polylactide-glycolide graft material in adult animals. Material and methods: Bone defects were prepared in right and left femora of 12 month-old male Wistar rats. The defects in one leg received the synthetic graft material and the contra-lateral defects did not receive any treatment. After four days, the animals were subjected to euthanasia, the femora were removed, and tissue blocks were prepared for histological analysis. Results: Blood clot remained in the centre of control defects with initial connective tissue organization on the edges. The graft material was observed in the centre of the treated defects, restricted to the area where it was applied, with neovascularization next to the graft material. The pattern of bone healing did not differ between groups, starting from the margins of the defects and from bone fragments, with neovascularization followed by deposition of non-mineralized bone matrix towards the centre. Conclusion: The results indicate that the lactide-glycolide copolymer gel was effective as a filling and osteoconductive material, allowing tissue healing during its resorption process. Additional studies are necessary to verify its capacity to promote bone regeneration.
Subclavian Vein Collapsibility as a Predictor of Fluid Responsiveness in
Spontaneously Breathing Hypotensive Patients
Authors: Mahendran Manjit , Kumar Arvind , Hari Smriti , Usman Mohd , Ahmad Khan Maroof , Ranjan Piyush , Soneja Manish , Vikram Naval K. , Biswas Ashutosh , Aggarwal Praveen , Wig Naveet
Published: April 2023

Background and Objective:

Volume replacement remains the cornerstone of resuscitation in critically ill patients. This study explored the ability of the subclavian vein collapsibility index to predict fluid responsiveness.

Methods:

In this prospective observational study conducted in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, sonographic evaluation of inferior vena cava and the right subclavian vein was carried out at three time points for hypotensive patients admitted to the emergency department. The study population was divided into two groups: responders and non-responders, based on a ≥ 15 % increase in stroke volume following fluid bolus.

Results:

Among 45 recruited patients, 33 patients were responders. The area under the ROC curve for SCV CI at baseline to predict fluid responsiveness was 0.745 (95% confidence interval: 0.549 – 0.941; p = 0.014). An SCV-CI of 46 % predicted fluid responsiveness in a hypotensive patient in terms of change in stroke volume by 15% following fluid bolus with a sensitivity of 87.88 % (95 % confidence interval: 71.80% to 96.60%) and specificity of 66.67 % (95 % confidence interval: 34.89% to 90.08%). Spearman’s correlation coefficient between IVC CI and SCV CI was 0.59 (p < 0.001, n = 135).

Conclusion:

The results of the study demonstrated that right subclavian vein respiratory variation has the ability to predict fluid responsiveness in a spontaneously breathing patient in circulatory shock and correlates with the inferior vena cava collapsibility index. The subclavian vein can be an alternative to the inferior vena cava in predicting fluid responsiveness in spontaneously breathing patients.
Evaluation of Doxorubicin-loaded Echogenic Macroemulsion for Targeted
Drug Delivery
Authors: Park Jong-Ryul , Kim Gayoung , Won Jongho , Kim Chul-Woo , Park Donghee
Published: April 2023

Background:

The latest technology trend in targeted drug delivery highlights stimuliresponsive
particles that can release an anticancer drug in a solid tumor by responding to external
stimuli.

Objective:

This study aims to design, fabricate, and evaluate an ultrasound-responsive drug delivery
vehicle for an ultrasound-mediated drug delivery system.

Methods:

The drug-containing echogenic macroemulsion (eME) was fabricated by an emulsification
method using the three phases (aqueous lipid solution as a shell, doxorubicin (DOX) contained oil, and
perfluorohexane (PFH) as an ultrasound-responsive agent). The morphological structure of eMEs was
investigated using fluorescence microscopy, and the size distribution was analyzed by using DLS. The
echogenicity of eME was measured using a contrast-enhanced ultrasound device. The cytotoxicity was
evaluated using a breast cancer cell (MDA-MB-231) via an in vitro cell experiment.

Results:

The obtained eME showed an ideal morphological structure that contained both DOX and PFH
in a single particle and indicated a suitable size for enhancing ultrasound response and avoiding complications
in the blood vessel. The echogenicity of eME was demonstrated via an in vitro experiment,
with results showcasing the potential for targeted drug delivery. Compared to free DOX, enhanced cytotoxicity
and improved drug delivery efficiency in a cancer cell were proven by using DOX-loaded
eMEs and ultrasound.

Conclusion:

This study established a platform technology to fabricate the ultrasound-responsive vehicle.
The designed drug-loaded eME could be a promising platform with ultrasound technology for targeted
drug delivery.
Application of Deep Learning in the Diagnosis of Alzheimer’s and Parkinson’s
Disease: A Review
Authors: Suganya Asokan , Aarthy Seshadri Lakshminarayanan
Published: April 2023

Most neurodegenerative diseases such as Alzheimer's and Parkinson's are life-threatening, critical, and incurable affecting mainly the elderly
population. Early diagnosis is challenging as disease phenotype is very crucial for predicting, preventing the progression, and effective drug
discovery. In the last few years, Deep learning (DL) based neural networks are the state-of-the-art models deployed in industries and academics
across different areas like natural language processing, image analysis, speech recognition, audio classification, and many more It has been slowly
realized that they have a high potential in medical image analysis and diagnostics and medical management in general. As this field is vast and
expanding rapidly, we have put focused on existing DL-based models to detect Alzheimer’s and Parkinson's in particular. This study gives a
summary of related medical examinations for these diseases. Frameworks and applications of many deep learning models have been discussed. We
have given precise notes on pre-processing techniques used by various studies for MRI image analysis. An overview of the application of DLbased
models in different stages of medical image analysis has been conferred. It has been realized from the review that more studies are focused
on Alzheimer's compared to Parkinson's disease Additionally, we have tabulated the various public datasets available for these diseases. We have
highlighted the potential use of a novel biomarker for the early diagnosis of these disorders. Also, some challenges and issues in implementing
deep learning techniques for the detection of these diseases have been addressed. Finally, We concluded with some future research directions
regarding deep learning techniques for diagnosis of the above diseases.
A Detailed Review of Molecular Pathways and Mechanisms Responsible for the
Development and Aggravation of Neuropathy and Nephropathy in Diabetes
Authors: Saraswat Nikita , Chandra Phool , Sachan Neetu , Vyawahare Niraj
Published: April 2023

Background:

Diabetic mellitus is responsible for triggering many conditions, such as neuropathy, nephropathy, and retinopathy. Hyperglycemia leads to the development of oxidative stress conditions, activation of pathways, and generation of metabolites, leading to complications like neuropathy and nephropathy.

Objective:

This paper aims to discuss the mechanism of actions, pathways, and metabolites triggered due to the development of neuropathy and nephropathy post-long-haul diabetes in patients. The therapeutic targets are also highlighted, proving to be a potential cure for such conditions.

Methods:

Research works were searched from international and national databases with keywords like “diabetes,” “diabetic nephropathy,” “NADPH,” “oxidative stress,” “PKC,” “Molecular mechanisms,” “ cellular mechanisms,” “complications of diabetes,” and “factors.” The databases searched were PubMed, Scopus, Directory of open access journals, Semantic Scholar, Core, Europe PMC, EMBASE, Nutrition, FSTA- Food Science and Technology, Merck Index, Google Scholar, PubMed, Science Open, MedlinePlus, Indian citation index, World Wide Science, and Shodhganga.

Results:

Pathways causing protein kinase C (PKC) activation, free radical injury, oxidative stress, and aggravating the conditions of neuropathy and
nephropathy were discussed. In diabetic neuropathy and nephropathy, neurons and nephrons are affected to the extent that their normal physiology
is disturbed, thus leading to further complications and conditions of loss of nerve sensation in diabetic neuropathy and kidney failure in diabetic
nephropathy.

:

Current treatment options available for the management of diabetic neuropathy are anticonvulsants, antidepressants, and topical medications,
including capsaicin. According to AAN guidelines, pregabalin is recommended as the first line of therapy, whereas other drugs currently used for
treatment are gabapentin, venlafaxine, opioids, amitriptyline, and valproate.

:

Drug targets for treating diabetic neuropathy must suppress the activated polyol pathways, kinase C, hexosamine, and other pathways, which
amplify neuroinflammation. Targeted therapy must focus on the reduction of oxidative stress and proinflammatory cytokines and suppression of
neuroinflammation, NF-κB, AP-1, etc.

Conclusion:

Potential drug targets must be considered for new research on the treatment of neuropathy and nephropathy conditions.
Universiteit van het Noorden: vier eeuwen academisch leven in Groningen: Deel 2 De klassieke universiteit 1876-1945
Authors: van Berkel Klaas
Published: April 2023

In de driekwart eeuw tussen 1876 en 1945 ontstond in Nederland de klassieke universiteit: de universiteit waarin de hoogleraren alles voor het zeggen hadden, waar de studenten in zalige onmaatschappelijkheid hun gang konden gaan en waarin wetenschap een hoge morele, vormende betekenis had. De Groningse universiteit was een waardige representant van deze inmiddels verdwenen universiteit, waar nog vaak met nostalgie naar wordt teruggekeken. Voor de Rijksuniversiteit Groningen was het een soms heftige periode: de universiteit werd eerst bijna opgeheven, vervolgens omgevormd tot een universiteit met internationale betekenis, een universiteit die in tijden van crisis en depressie overeind bleef, maar ten slotte diep moest buigen voor de Duitse bezetter.
Delayed Complete Chorioamniotic Membrane Separation in the Third Trimester Following a Motor Vehicle Collision
Authors: R. Addicott, MD Katherine , N. Cottrell, MD Jesse
Published: April 2023

Complete separation of the amnion and chorion is a rare pregnancy complication. The proposed causes for chorioamniotic separation are failure of fusion,spontaneous separation, and iatrogenically from invasive prenatal pro-cedures. We present the first reported case of delayed complete chorioamniotic separation following a motor vehicle collision. Close fol-low-up with serial fetal ultrasounds resulted in a favorable outcome
Influence of INM on Performance of Soybean-Wheat based Cropping System under Central Narmada Agro-Climatic Zone of Madhya Pradesh
Authors: Kumar Vinod , Mishra S K
Published: April 2023

A field experiment was conducted to evaluate organic vis-à-vis inorganic fertilizers and soil sustainability in soybean-wheat cropping sequence for two consecutive years. Grain yield of both the crops, i.e., soybean (16.29 q/ha) and wheat (46.05 q/ha) was observed to be significantly superior by fertilizer application as per general recommended dose of respective crops. Integrated application of fertilizers i.e., inorganic fertilizers 50% and organic fertilizers 50% was found to be the next superior treatment to that of general recommended dose. Soil properties were improved by use of organic and inorganic fertilizers in combination. However, no significant change was observed in case of soil pH and electrical conductivity.
Assessment of genetic variability, heritability and genetic advance of Chrysanthemum
Authors: SHINGALA MANSI , KUMARI KIRAN , SUNDESHA D L
Published: April 2023

An experiment was conducted to study genetic variability, heritability and genetic advance among twenty varieties of chrysanthemum (Chrysanthemum morifolium Ramat.) at the College Farm, College of Horticulture, Department of Floriculture and Landscape Architecture, SDAU, Jagudan during 2020-21. A wide variation in performance of the varieties were recorded for various growth, flowering, yield and quality parameters and results shows that magnitude of the phenotypic coefficient of variation (PCV) was higher than genetic coefficient of variance (GCV). High GCV and PCV was recorded for fresh weight of flower followed by number of leaves per plant, number of flowers per plant, number of primary branches, shelf life, yield of flowers per plant and yield of flowers per plot. High heritability along with high genetic advance as per cent of mean was observed for number of leaves per plant, days to full bloom, number of flowers per plant, yield of flowers per plant and yield of flowers per ha. Further, these characters could be exploited for improvement through breeding programme.
Assessment of Impact of Demonstrations on Vegetable Crops in Bundelkhand
Authors: OLA ARJUN LAL , PAL SUNDAR , SINGH SAURABH , TIWARI DEVESH
Published: April 2023

During Kharif 2021, an investigation was carried out in Prathvipura village, block Babina, district Jhansi, and the Bundelkhand region of Uttar Pradesh. A total of ten demonstrations on vegetables showed their production potential: bhindi, sponge gourd, brinjal, amaranth, and cowpea bean variety A-5, Pusa Sneha, Pusa Hara, Pusa Kiran, and Pusa Sukomal. Increased yields of 8.33, 9.38, 11.54, and 9.38 percent were recorded from bhindi, sponge gourd, brinjal, and cowpea crops, respectively, where the extension gap was 1500, 1500, 3000, and 1500 kg/ha. The technology gap was observed at 1000, 0, 4000, -50, and 5 kg/ha for cowpea, bhindi, brinjal, sponge gourd, and amaranth, where the technology index was 5.88, 0, 13.33, -0.31, and 3.85 percent, respectively. The highest net returns were observed for 95,000, 102,500, 120,500, 122,500, and 145,500 Rs from sponge gourd, amaranth, cowpea, bhindi, and brinjal, with cost-benefit ratios of 1.46, 2.73, 2.66, 2.13, and 2.32 after each rupee investment, followed by a local check.
Evolution of a Project to Improve Inpatient-to-Outpatient Dermatology Care Transitions: Mixed Methods Evaluation
Authors: Kling Samantha M R , Aleshin Maria A , Saliba-Gustafsson Erika A , Garvert Donn W , Brown-Johnson Cati G , Amano Alexis , Kwong Bernice Y , Calugar Ana , Shaw Jonathan G , Ko Justin M , Winget Marcy
Published: April 2023

Background

In-hospital dermatological care has shifted from dedicated dermatology wards to consultation services, and some consulted patients may require postdischarge follow-up in outpatient dermatology. Safe and timely care transitions from inpatient-to-outpatient specialty care are critical for patient health, but communication around these transitions can be disjointed, and workflows can be complex.

Objective

In this 3-phase quality improvement effort, we developed and evaluated an intervention that leveraged an electronic health record (EHR) feature, known as SmartPhrase, to enable a new workflow to improve transitions from inpatient care to outpatient dermatology.

Methods

Phase 1 (February-March 2021) included interviews with patients and process mapping with key stakeholders to identify gaps and inform an intervention: a SmartPhrase table and associated workflow to promote collection of patient information needed for scheduling follow-up and closed-loop communication between dermatology and scheduling teams. In phase 2 (April-May 2021), semistructured interviews—with dermatologists (n=5), dermatology residents (n=5), and schedulers (n=6)—identified pain points and refinements. In phase 3, the intervention was evaluated by triangulating data from these interviews with measured changes in scheduling efficiency, visit completion, and messaging volume preimplementation (January-February 2021) and postimplementation (April-May 2021).

Results

Preintervention pain points included unclear workflow for care transitions, limited patient input in follow-up planning, multiple messaging channels (eg, EHR based, email, and phone messages), and time-inefficient patient tracking. The intervention addressed most pain points; interviewees reported the intervention was easy to adopt and improved scheduling efficiency, workload, and patient involvement. More visits were completed within the desired timeframe of 14 days after discharge during the postimplementation period (21/47, 45%) than the preimplementation period (28/41, 68%; P=.03). The messaging workload also decreased from 88 scheduling-related messages sent for 25 patients before implementation to 30 messages for 8 patients after implementation.

Conclusions

Inpatient-to-outpatient specialty care transitions are complex and involve multiple stakeholders, thus requiring multifaceted solutions. With deliberate evaluation, broad stakeholder input, and iteration, we designed and implemented a successful solution using a standard EHR feature, SmartPhrase, integrated into a standardized workflow to improve the timeliness of posthospital specialty care and reduce workload.
Loss dan Gain Penerjemahan Kala Passé Composé pada Novel L’Appel de L’Ange dalam Bahasa Indonesia
Authors: Aisyi Syifa Hazimah Hana , Sajarwa
Published: April 2023

Fenomena loss dan gain ditemukan pada hampir setiap terjemahan, salah satunya terjadi pada penerjemahan kala passé composé dari bahasa Prancis ke bahasa Indonesia. Dalam bahasa Prancis, kala merupakan aspek gramatikal yang terletak pada tatanan morfo-sintaksis yang melekat pada verba. Sementara dalam bahasa Indonesia yang tidak mengenal kala, terdapat penyebutan waktu yang menjadi padanan dari kala menggunakan sistem semantik. Karena perbedaan tersebut, penerjemahan kala passé composé dari bahasa Prancis ke bahasa Indonesia mengalami loss dan gain. Berdasarkan hal tersebut, penelitian ini bertujuan untuk menganalisis bentuk loss dan gain dalam penerjemahan kala passé composé dalam novel L’Appel de L’Ange dan terjemahannya dalam bahasa Indonesia, Call From an Angel, yang diterjemahkan oleh Yudith Listiandri. Metode yang digunakan dalam penelitian ini adalah deskriptif-kualitatif-komparatif. Teori yang digunakan dalam penelitian ini adalah teori loss dan gain, terjemahan, passé composé, dan penerjemahan kala dalam bahasa Indonesia. Hasilnya, data loss dibedakan menjadi dua kategori: 2 tanpa disertai pemarkah dan 9 disertai pemarkah yakni afiksasi dan verba material. Selain itu, 16 data gain ditemukan dengan 2 data tanpa pemarkah dan 14 data disertai pemarkah yakni preposisi, konjungsi, dan adverbia.
Effect of Clove Powder Syzygium aromaticum Supplementation on Growth and Health Status of Cantang Grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) in Floating Net Cage
Authors: Ode Inem , Sukenda Sukenda , Widanarni Widanarni , Wahjuningrum Dinamella , Yuhana Munti , Setiawati Mia
Published: April 2023

Cantang grouper is a hybrid grouper which is one of the main grouper species cultivated in Indonesia. This study aimed to evaluate the growth and health status of cantang grouper in floating net cages supplemented with clove powder. This study used a completely randomized design with three treatments, each with three replications. Two levels of clove powder dose used were 10 and 15 g kg-1 and one treatment without clove powder dose (control). Feed treatment using the repelletting method. Parameters observed were growth, survival rate, levels of malondialdehyde and superoxide dismutase enzyme, blood parameters, phagocity activity, total bacterial count (TBC) and total vibrio count (TVC). The results showed that the treatment of clove powder supplementation in cantang grouper feed for 30 days was able to increase the growth, survival rate, activity of the enzyme superoxide dismutase (SOD), and differential leukocyte (lymphocyte). The application of clove powder in the feed did not significantly affect the total erythrocytes, leukocytes, hematocrit, phagocytic activity, total bacterial count (TBC) and total vibrio count (TVC) of hybrid grouper in floating net cages. The conclusion of this study, administration of clove powder at a dose of 15 g kg-1 feed was able to significantly increased growth, differential leukocyte (lymphocyte), and survival rate of cantang grouper in floating net cages.
Utilization of Barracuda Fish Skin Gelatin (Sphyraena) in Making Body Lotion with the Addition of Liquid Smoke as an Antioxidant and Antibacterial
Authors: Swastawati Fronthea , Al Hayat Syarifah Sufi , Susanto Eko
Published: April 2023

Gelatin can be used as an emulsifier, thickener, and humectant in body lotions. Body lotion must contain natural ingredients that can prevent skin damage such as liquid smoke, which is a natural ingredient that can be used as an antioxidant and antibacterial. The purpose of this study was to determine the potential of gelatin on the features of body lotion and the effect of adding liquid immediately as an antioxidant and antibacterial. The treatments used were gelatin with different concentrations (0%, 1%, 3%, and 5%) in the opening study and liquid smoke concentrations of 0%, 0.3%, 0.5%, and 0.7% in the main study with three repetition times. Parameters observed were viscosity, hedonic, pH, antioxidant activity, and TPC. The analysis revealed that all test parameters had a significant effect (P<0.05). The addition of gelatin with a concentration of 3% was the best treatment, with a viscosity value of 2847± 89,37 cP (according to SNI 16-4399-1996) and a hedonic value of 5.73<µ<5.91 (preferred by the panelists). While the best treatment for adding liquid smoke as an antioxidant and antibacterial was 0,7% liquid smoke with an antioxidant activity value of 34.87±0.325%, a TPC value of 2.46±0.071 log colonies/g, a pH value of 7.12± 0.025 and did not cause skin irritation.
A Study to Evaluate the Effectiveness of Structured Teaching Program on Knowledge Regarding the Cause of Teenage Suicides and Its Solution among Teachers Working in Selected Rural Schools
Authors: Mahanta Dev Kumar
Published: April 2023

Abstract: The reasons behind a teen's suicide or attempted suicide can be complex. Although suicide is relatively rare among children, the rate of suicides and suicide attempts increases greatly during adolescence. Suicide rates differ between boys and girls. Girls think about and attempt suicide about twice as often as boys, and tend to attempt suicide by overdosing on drugs or cutting themselves.
Driver Drowsiness Detection and Alert System based on Visual Analysis using Machine Learning
Authors: Karegaonkar Rohit , Gaikwad Akshay , Ahirekar Rutik , Avatade Mohini
Published: April 2023

Abstract: The main idea behind this project is to develop a system that can detect the drowsiness of the driver and issue a timely warning. Driver Fatigue is the main reason for a large number of road accidents. The detection can be done in many different ways and by using different parameters. The proposed system uses the behavior of parameters. Our proposed method can distinguish the simulated drowsy and sleepy states from the normal state of driving on the resolution images of faces and eyes observed from an oblique viewing angle. This system treats the automatic detection of the driver's drowsiness based on visual information and artificial intelligence.
Planning of Affordable Housing for Slum Rehabilitation – A Review Approach
Authors: Saini Aditya , Bairwa Ashok , Sharma Hitesh , Choudhary Manish , Jangid Jetender B.
Published: April 2023

Abstract: This has been mainly attributed to shortage of public funds. However, some urban areas in these countries exhibit vibrant real estate markets that may hold the potential to bear the costs of regenerating slums. This paper sheds light on an innovative hypothesis to achieve slum regeneration by using waste products or affordable materials. The study seeks to answer the question “How can urban public policy facilitate slum regeneration, increase affordable housing”.
Terpenoid composition of Chenopodium ambrosioides L. and its Antimicrobial activity from Uttarakhand Himalaya of India
Authors: Bisht Balam Singh , Kumar Amit
Published: April 2023

ambrosioides var. ambrosioides essential oil has been commercialized to control greenhouse insects and mites and the aerial parts of this plant have been used as condiment; traditional purgative for intestinal worms and acesodyne and in the Chinese traditional medicine, this herb can expel wind and treat rheumatism. Further the essential oil of Chenopodium ambrosioides showed the antimicrobial activity against several microbial species. Our investigations therefore, reveal presence of another chemotype in this region with α-terpinene and p-cymene as chemical markers of this chemotypes and its antimicrobial activity.
RELAÇÃO ENTRE CONSELHO DE ADMINISTRAÇÃO E A POLÍTICA DE DIVIDENDOS: EVIDÊNCIAS DO BRASIL
Authors: Dos Santos José Éliton , Antonio Felix Júnior Luiz
Published: April 2023

Objetivo: A presente pesquisa teve como objetivo analisar a relação entre a composição dos conselhos de administração e a política de dividendos nas empresas não financeiras listadas na Brasil, Bolsa, Balcão (B3).
Método/abordagem: A pesquisa utilizou dados dos anos de 2010 a 2020 das empresas brasileiras não financeiras retirados da base de dados Economática e dos Formulários de Referência. Para obtenção dos resultados foram utilizados os métodos de regressão Logit, Tobit e GMM no software Stata.
Principais Resultados: Os resultados mostraram que o tamanho do conselho, a independência, a diversidade e dualidade do CEO causam impacto na declaração dos dividendos, no entanto, apenas o tamanho, o gênero e a dualidade do CEO impactam na política de pagamento de dividendos. Já a expertise financeira e a indicação pelos controladores não têm relação com a política de dividendos.
Contribuições teóricas/práticas/sociais: Na prática, os resultados demonstram que a composição dos conselhos de administração no Brasil é importante instrumento de proteção aos acionistas, principalmente os minoritários. No entanto, todos os investidores em geral devem levar a composição em conta, dado que a distribuição de dividendos faz parte da remuneração que eles esperam, e as empresas devem observar suas composições, uma vez que as características dos conselhos podem expropriar investidores.
Originalidade/relevância: Esta pesquisa é a primeira no cenário brasileiro ao analisar, de forma conjunta, diferentes aspectos da composição dos conselhos de administração na distribuição de dividendos. A pesquisa torna-se relevante ao explorar os efeitos da governança corporativa em decisões estratégicas das empresas como a política de dividendos.
An Implicit Finite Difference Method for Thin Film Flow
Authors: Putra Gusrian , Wiryanto Leo Hari , Widyawati Ratna
Published: April 2023

Thin film flow on an inclined plane can be modeled from lubrication theory. Together with boundary conditions, the governing equations can be formulated into a single equation of the thickness of the fluid, and solved numerically by an implicit finite difference method. In analyzing the equation, the linearized equation is considered here, to see the characteristic of the solution as wave propagation and the effect of the physical parameter. We found that the wave propagates by reducing the amplitude, and the wave speed is affected by the steepness of the plane. All of these can be indicated in the linearized equation. Numerical wave-simulation is presented in this paper.
On A Class of Real Quintic Moment Problem
Authors: El Boukili Abdelaziz , Rhazi Amar , El Wahbi Bouazza
Published: April 2023

The present paper is centered on a class of real quintic moment problem. We state some conditions for the existence of a representative measure and we provide it explicitly. We also state some cases where no representative measure exists. Some numerical examples are presented to illustrate construction of the representative measure as well as to highlight the conflicts behind the irresolvability.
Neutrosophic N−Ideals on Sheffer Stroke BCK-Algebras
Authors: Oner Tahsin , Katican Tugce , Rezaei Akbar
Published: April 2023

In this study, a neutrosophic N −subalgebra and neutrosophic N−ideal of a Sheffer stroke BCK-algebras are defined. It is shown that the level-set of a neutrosophic N−subalgebra (ideal) of a Sheffer stroke BCK-algebra is a subalgebra (ideal) of this algebra and vice versa. Then we present that the family of all neutrosophic N−subalgebras of a Sheffer stroke BCK-algebra forms a complete distributive modular lattice and that every neutrosophic N−ideal of a Sheffer stroke BCK-algebra is the neutrosophic N −subalgebra but the inverse does not usually hold. Also, relationships between neutrosophic N−ideals of Sheffer stroke BCK-algebras and homomorphisms are analyzed. Finally, we determine special subsets of a Sheffer stroke BCK-algebra by means of N−functions on this algebraic structure and examine the cases in which these subsets are its ideals.
Numerical Invariants of Coprime Graph of A Generalized Quaternion Group
Authors: Nurhabibah Nurhabibah , Wardhana I Gede Adhitya Wisnu , Switrayni Ni Wayan
Published: April 2023

The coprime graph of a finite group was defined by Ma, denoted by ΓG, is a graph with vertices that are all elements of group G and two distinct vertices x and y are adjacent if and only if (|x|, |y|) = 1. In this study, we discuss numerical invariants of a generalized quaternion group. The numerical invariant is a property of a graph in numerical value and that value is always the same on an isomorphic graph. This research is fundamental research and analysis based on patterns in some examples. Some results of this research are the independence number of ΓQ4n is 4n − 1 or 3n and its complement metric dimension is 4n − 2 for each n ≥ 2.
Analytical Method Development and Validation of Perindopril and Amlodipine as Multicomponent Formulation by HPLC Method
Authors: Godse Vinod D. , R. Kamble Dr Priyadarshani , S. Patil Taresh
Published: April 2023

The work aims to develop and validate a simple, precise and accurate HPLC method per ICH guidelines. The linearity, specificity, Precision, and accuracy were within limits specified by the ICH guidelines. Hence the proposed system was found to be robust and precise. The objective of this study was to validate the simultaneous assay of Perindopril and Amlodipine by using High-Performance Liquid Chromatography (HPLC). Perindopril and Amlodipine were estimated with C18 Column (2.5 cm × 4.6 mm and five μm particle size) with a VWD detector. The mobile phase consists of Buffer Solution and Acetonitrile 55:45 v/v with a flow rate of 1 ml/min. The volume injected was 20 μL. The detection wavelength was 215 nm, respectively. The retention time of Perindopril and Amlodipine was found to be 3.40 min and 4.73 min. The system suitability and all essential validation parameters were meticulously completed. The LOD and LOQ for Perindopril were found to be 2.62 μg/ml and 7.95 μg/ml, respectively, and for Amlodipine, 1.06 μg/ml and 3.22 μg/ml, respectively. The analytical curve was linear (R2 = 0.999). The system exhibits sufficient accuracy with a relative standard deviation under 2%. The method showed good duplicability and recovery with % RSD less than 2%. The linearity, specificity, Precision, and accuracy were within limits specified by the ICH guidelines. Hence the proposed system was found to be robust and precise. The method has to be such that it takes less time development and the best accurate and complete results have been obtained. Hence the proposed method for simultaneous estimation of Perindopril and Amlodipine by HPLC was found to be robust and precise.
ON THE CONCEPT OF "ECONOMIC ACTIVITY" IN PRIVATE LAW
Authors:   Институт государства и права Российской академии наук, Москва, Россия, Мариетта Дамировна Шапсугова
Published: April 2023

In connection with the change in the nomenclature of scientific specialties, the term "economic activity", which was used mainly in the field of public law, is firmly in use in the field of private law sciences. In the article, in relation to related categories, the concept of "economic activity" is analyzed in the private legal aspect, the classification of types of economic activity, its main forms is given. The practical significance of understanding the content of the concept of "economic activity" is to determine its legal regime, the legal status of subjects, the distinction between the subject of civil and arbitration procedural legislation.
СRIMINAL REPETITION: DENIAL OF DENIAL
Authors:   Дальневосточный институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте Российской Федерации, Хабаровск, Россия, Олег Владимирович Куликов
Published: April 2023

The article is devoted to the institution of repeated crimes, traditional for Russian criminal law, effective, but excluded at one time from the criminal law. For a certain time, criminal repetition existed only as a scientific category. In the General part of the Criminal law, only certain signs of repetition are mentioned, but there is no definition of it, as well as legal regulation. The need to strengthen counter-action by criminal legal means to certain types of crimes contributed to the beginning of the process of returning norms with a sign of repetition to a Special part of the Criminal Code of Russia. The tendency to expand and increase the number of such norms in the future will require the development of appropriate general provisions. The causal conditionality of the full-fledged return of the institution of repetition to the criminal law is revealed, a possible solution to this issue is proposed.
N. N. ALEKSEEV'S SCIENTIFIC APPROACH TO CHOOSING THE PATH OF CULTURAL AND CIVILIZATIONAL DEVELOPMENT OF RUSSIA
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Татьяна Владимировна Шатковская ,   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия
Published: April 2023

The article is aimed at updating the political and legal discourse on ways to improve the state system in Russia. The author proposes to comprehend the works of N. N. Alekseev scientifically and critically, who proposed the theory of a righteous (guarantee) state. The article proves that this model corresponds to the mental characteristics of Russians and at the same time is based on the universal values of freedom, equality, truth, peace, harmony, unity, justice, which are the essence of law. The author concludes that the key ideas and scientific approaches of N. N. Alekseev not only remain relevant but can also be an example of a theoretical justification for the development strategy of the Russian state.
Tetrazole Derivatives and Role of Tetrazole in Medicinal Chemistry:An Article Review
Authors:   Forensic DNA Research and Training Center, Al-NahrainUniversity, Jadriya, Baghdad, Iraq, A. Jawad Asmaa , R. Jber Nasreen ,   Department of Chemistry, College of Science, Al-Nahrain University, Jadriya, Baghdad, Iraq, S. Rasool Baneen ,   Al Hikma University, Baghdad, Iraq, K. Abbas Abbas ,   Muthanna Agriculture Directorate, Ministry of Agriculture, Al-Muthanna, Iraq
Published: April 2023

The review generalizes and systematizes in this review the results of research on the synthesis and properties of tetrazole derivatives and the properties of tetrazole compounds, and synthetic routes. In medical chemistry, the tetrazole compounds play a big role in medicinal applications such as antibacterial, anticancer, and effects on the central nervous system.
Henry Fielding as a Judge
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Zykova Ekaterina P.
Published: April 2023

Fielding’s activities as a judge, his legal views and the works where he touched upon the law points often attracted the attention of the scholars abroad, but were sparsely covered in the works written in this country. Yet the interest for law was not incidental in Fielding’s life, but rested on the idea (supported by him) of the great public importance of the judge’s calling, whose operations can be both beneficial and ruinous for the whole nation and state let alone for a single person. His own legal practice invariably caused a wide public response, as well as his open expression of his views on the particular law cases, because of the unique combination of literary fame and legal knowledge in his own person. This very combination also stimulated the profitable interchange of his writer’s and judge’s experience, rendering complicated law cases a subject of fictional representation in his dramas and novels and also a matter of discussion in his pamphlets and journal work (such as A True State of the Case of Bosavern Penlez and A Clear State of the Case of Elizabeth Canning). Pointing out the interrelation of Fielding’s legal views and his moral ideas, the author of the article observes a certain discrepancy between the writer’s habitual benevolence and his generalized social ideas relying on the tradition of the high estimation of law as the overriding principle of social life.
ANALISIS PEMASARAN PRODUK KOPI PADA IKM TO KULAWI DI KECAMATAN KULAWI SELATAN KABUPATEN SIGI
Authors: Astian Skander , S. Hamzens Wildani Pingkan , A. Laihi Moh Alfit
Published: April 2023

Penelitian ini bertujuan untuk mengetahui Bentuk saluran pemasaran. besaran margin pemasaran, besarnya bagian harga yang diterima oleh produsen, dan tingkat efisiensi yang telah dicapai dalam pemasaran produk kopi pada IKM To Kulawi Di Kecamatan Kulawi Selatan Kabupaten Sigi. Penentuan responden dilakukan secara sengaja (purposive) yang terdiri dari satu pimpinan, dua karyawan, satu pedagang pengecer dan satu orang konsumen. Penelitian ini menggunakan analisis margin pemasaran, efisiensi pemasaran dan bagian harga. Penelitian ini dilaksanakan pada bulan September 2022. Hasil dari penelitian ini didapatkan ada dua Bentuk saluran pemasaran produk kopi pada IKM To Kulawi: Saluran pertama: Produsen – Konsumen, Saluran kedua: Produsen – Pedagang pengecer – konsumen. Besar margin pemasaranpada saluran pertama dari produsen kekonsumen tidak memiliki margin pemasaran, disebabkan karena tidak ada pedagang perantara yang terlibat dalam pemasaran, konsumen datang langsung kepada produsen untuk membeli produk kopi to kulawi, pada saluran kedua dari produsen ke pedagang pengecer memiliki margin sebesar Rp 5.000. Bagian harga yang diterima Pada saluran Pertama sebesar Rp 10.000 dengan

presentase 100 %, besar bagian harga pada saluran kedua adalah sebesar Rp 15.000 dengan presentase 66,67 %. Tingkat efisiensi yang dicapai oleh produsen pada saluran pertama sebesar 17,5%, dan tingkat efisiensi pada saluran kedua sebesar 20%.
ANALISIS NILAI TAMBAH DAN PENDAPATAN PISANG SALE PADA CV. RAJA BAWANG DI KOTA PALU
Authors: Triana John Yeis , Asih Dewi Nur , Nurdin Muh Fahruddin
Published: April 2023

Penelitian ini dilaksanakan pada CV. Raja Bawang di Kota Palu. Lokasi penelitian ditentukan secara sengaja (purposive), yakni pada industri CV. Raja Bawang yang terletak di Jl. Abdurahman Saleh No. 33 Kelurahan Birobuli Selatan Kecamatan Palu Selatan Kota Palu. Penelitian ini dilaksanakan padabulan Juli-Agustus 2022. Responden pada penelitian ini adalah pimpinan dan karyawan CV. Raja Bawang di Kota Palu. Analisis yang digunakan adalah analisis nilai tambah (Metode Hayami) dan analisis pendapatan. Hasil penelitian menunjukan bahwa nilai tambah yang diperoleh dari hasil pengolahan pisang menjadi pisang sale sebesar Rp34.300, dengan keuntungan sebesar Rp29.470 atau sebesar 85,91% yang berarti tingkat keuntungan yang diperoleh CV. Raja Bawang dari produksi pisang sale meningkatkan pertumbuhan ekonomi industri. Hal ini menunjukan adanya nilai tambah yang bernilai positif dan rasio nilai tambah produksi pisang sale sebesar 72,21% atau Rp24.768 dipengaruhi oleh besarnya nilai output, harga bahan baku, dan nilai sumbangan input lain. Produksi pisang sale pada CV. Raja Bawang selama Bulan Juli tahun 2022 menggunakan 221 Kg pisang dan menghasilkan 125 Kg pisang sale. Besarnya pendapatan produksi pisang sale pada CV. Raja Bawang sebesar Rp6.016.165.
EVALUASI KELAYAKAN FINANSIAL USAHA PENGOLAHAN IKAN TERI KERING (Studi Kasus: Bapak Alwi Di Kelurahan Mamboro Kecamatan Palu Utara KOTA PALU)
Authors: Virgianto Seeti , Laapo Alimuddin , Safitri Dian
Published: April 2023

Penelitian ini penelitian ini bertujuan untuk mengetahui kelayakan finansial pada usaha pengolahan ikan teri kering di Kelurahan Mamboro Kecamatan Palu Utara Kota Palu. Hasil Analisis Kelayakan Usaha Pengolahan Ikan Teri Kering di Kelurahan Mamboro diperoleh hasil Net Present Value (NPV) sebesar Rp. 53.476. Hal ini menunjukkan bahwa NPV positif (NPV > 0), sehingga usaha pengolahan ikan teri kering di Kelurahan Mamboro dinyatakan layak untuk dijalankan. Hasil Profitability Index (PI) yang di peroleh sebesar 1,01 > 1 yang artinya PI lebih besar dari 1 sehinga usaha pengolahan ikan teri kering di Kelurahan Mamboro layak untuk dijalankan. Hasil Internal Rate of Return (IRR) yang diperoleh adalah 16,34% yang artinya usaha pengolahan ikan teri kering di Kelurahan Mamboro layak untuk dijalankan karena tingkat pengembalian suku bunga lebih besar dari pada suku bunga yang berlaku yaitu i = 10%. Berdasarkan hasil perhitungan Payback Period (PP) yang diperoleh memiliki masa pengembalian investasi selama 3 tahun 11 bulan yang artinya jangkawan waktu tersebut biaya investasi yang

dikeluarkan dapat kembali, jadi semakin cepat jangka waktu pengembalian investasi maka, usaha yang dijalankan semakin lancar.
PENENTUAN KOMODITAS BASIS SUBSEKTOR HORTIKULTURA BUAH-BUAHAN DI KABUPATEN PARIGI MOUTONG
Authors: Tri Aldy Komang Agus , S. Hamzens Wildani Pingkan , Wibawa I Gede Laksana
Published: April 2023

Penelitian ini bertujuan untuk mengetahui komoditas basis dari subsektor Hortikultura yang ada pada Kabupaten Parigi Moutong. Subsektor Hortikultura merupakan salah satu subsektor pertanian yang memiliki potensi dalam membangun pertanian di Kabupaten Parigi Moutong, namun besarnya kontribusi

sektor pertanian pada Kabupaten Parigi Moutong, berbanding terbalik dengan laju pertumbuhan yang terjadi di Kabupaten Parigi Moutong artinya pembangunan pada sektor pertanian tidak dimanfaatkan secara optimal dengan kontribusi yang diberikan. Dengan menganalisis persentase Komoditas Basis

Subsektor Hortikultura di Kabupaten Parigi Moutong dengan menggunakan metode Persentase dan Analisis LQ (Location Quotient) yang dilaksanakan di Kabupaten Parigi Moutong, dapat meningkatkan Sektor Pertanian di Kabupaten Parigi Moutong sebsgai salah satu penyumbang terbesar dalam sektor

pertanian khususnya pada subsektor hortikultura dan pendapatan Masyarakat yang ada di Kabupaten Parigi Moutong.
STRATEGI PEMASARAN NUGGET IKAN PADA IKM ADI JAYA KELURAHAN NUNU KECAMATAN TATANGA KOTA PALU
Authors: Munir Misbakus , S. Hamzens Wildani Pingkan , Safitri Dian
Published: April 2023

Penelitian ini bertujuan untuk Mengetahui bagaimana strategi pemasaran produk nugget ikan sesuai kondisi lingkungan internal dan eksternal, serta alternatif strategi pemasaran dalam mendukung usaha IKM Adi Jaya di Kota Palu. Penelitian dilaksanakan di IKM Mas Adi Jaya, Jln. Sungai Ogotion, Kelurahan Nunu, Kec. Tatanga, Palu barat kota Palu. Penelitian ini dilaksanakan pada bulan April sampai Juni 2021. Responden dalam penelitian ini yaitu Pimpinan IKM Adi Jaya, 2 karyawan dan 2 konsumen pada IKM Adi Jaya. Metode analisis yang digunakan dalam penelitian ini adalah analilsis SWOT. Hasil analisis dari matriks SWOT IFAS dan EFAS menunjukkan bahwa strategi pemasaran produk nugget ikan pada IKM Adi Jaya berada pada kuadran I, maka strategi difokuskan pada strategi SO yaitu menggunakan kekuatan yang dimiliki dalam memanfaatkan peluang yang ada. Alternatif S-O yaitu : (a). Memanfaatkan tempat yang strategis untuk memenuhi permintaan produk yang cenderung meningkat, (b). Memanfaatkan merek produk yang mulai dikenal, (c). Menetapkan harga yang bisa dijangkau oleh konsumen, (d). Tersedianya teknologi dalam produksi membantu pada pelaku usaha untuk lebih berkembang kedepannya, (e) Dengan adanya modal maka akan membuat industri ini memiliki potensi pemasaran yang lebih luas, (f) Produksi yang mulai meningkat karena tidak terlepas dari adanya hubungan yang baik dengan konsumen.
Generalized uncertainty principle and the solution limits of the Schrödinger equation due to attenuated eigenfunction
Authors: Abdel-Rahman A. , Sabry Youssef A.
Published: April 2023

General Relativity, quantum gravity, black hole physics, and string
theory all indicate the possibility of the existence of a minimal
observable length in the order of Planck length. This notice and others
lead to modifying the Heisenberg uncertainty principle to be the
Generalized Uncertainty Principle (GUP), as illustrated in many
literatures. While the base of quantum mechanics, the Schrödinger
equation, did not show this principle, it was used to solve many
problems without indicating the limits of their solutions. Here, in this
study, some consequences of GUP in the quantum mechanics spirit were
presented in one of the most well-known quantum problems: a particle in
a one-dimensional box. The study shows a suggested term to be added to
the Schrödinger equation, which is derived from an attenuated
wavefunction and describes the particle dimension as well as its wave
nature according to a minimal length. This concept can be used to solve
high-energy physics problems and black hole problems, besides Hawking
radiation.
NETosis Induced by Serum of Patients with COVID-19 is Reduced with Reparixin or Antibodies Against DEK and IL-8.
Authors: Kılıç İrfan , Yaşar Açelya , Camcı İrem Yalım , Güzel Türkan , Karahasan Ayşegül , Yağcı Tamer , Çine Naci , Kandilci Ayten
Published: April 2023

DEK locates in the nucleus of the cells or the cytoplasmic granules of
neutrophils and plays different roles in cellular processes including
NETosis, a suicide mechanism of neutrophils. Here we showed that the
interaction of rDEK with CXCR2 leads to NETosis, which could be reduced
by the CXCR1/CXCR2 inhibitor reparixin. We found that IL-8, IL-6, IL1-β,
MPO, and CitH3 were increased whereas DEK was decreased in the serum of
COVID-19 patients. Interestingly, reparixin or anti-DEK antibody reduced
the NETosis induced by the patients’ serum, suggesting that initial
cytokine stimulation may further induce the release of DEK. Our results
support the use of reparixin as a potential therapeutic strategy in
COVID-19 and suggest that DEK-CXCR2 interaction plays a role in NETosis.