bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Temperature on the Capacity of Lithium Ion Batteries with Different Anodes
Authors: Lv Shuaishuai , Wang Xingxing , Lu Wenfan , Zhang Jiaqiao , Ni Hongjun
Published: December 2021

Temperature is considered to be an important indicator that affects the capacity of a lithium ion batteries. Therefore, it is of great significance to study the relationship between the capacity and temperature of lithium ion batteries with different anodes. In this study, the single battery is used as the research object to simulate the temperature environment during the actual use of the power battery, and conduct a charge and discharge comparison test for lithium iron phosphate battery, lithium manganate battery and lithium cobalt oxide battery. In the test of capacity characteristics of lithium ion batteries of three different cathode materials at different temperatures, the optimal operating temperature range of the lithium ion battery is extracted from the discharge efficiencies obtained. According to the research results, the discharge capacity of a lithium ion battery can be approximated by a cubic polynomial of temperature. The optimal operating temperature of lithium ion battery is 20–50 °C within 1 s, as time increases, the direct current (DC) internal resistance of the battery increases and the slope becomes smaller. Between 1 s and 10 s, the DC internal resistance of the battery basically shows a linear relationship with time. In the charge and discharge process, when state of charge (SOC) 0% and SOC 100%, the internal resistance of the battery is the largest. The SOC has the greatest impact on the polarization internal resistance, and the smallest impact on the ohmic internal resistance.
Helen Nemanjić (1250–1314)
Authors: Marinković Čedomila
Published: December 2021

Queen Helen Nemanjić (1250–Brnjaci near Zubin Potok, February 8, 1314) was a Serbian medieval queen and consort of King Stefan Uroš I (r. 1243–1276), the fifth ruler of the Serbian Nemanide dynasty. She was the mother of the kings Stefan Dragutin and Stefan Uroš II Milutin. Today, she is known as Helen of Anjou (Jelena Anžujska in Serbian) although her real name was most probably Heleni Angelina (Ελένη Aγγελίνα). She was the founder of the Serbian Orthodox monastery of Gradac as well as four Franciscan abbeys in Kotor, Bar, Ulcinj, and Shkodër. Together with her sons, Kings Stefan Dragutin and Stefan Uroš II Milutin she helped renovation of Benedictine abbey of Sts. Sergius and Bacchus near Shkodër on Boyana river in present-day Albania. After the death of her husband, she ruled Zeta and Travunija until 1306. She was known for her religious tolerance and charitable and educational endeavors. She was elevated to sainthood by the Serbian Orthodox Church. Along with Empress Helen, the wife of Serbian Emperor Stefan Uroš IV Dušan, Queen Helen was the most frequently painted woman of Serbian medieval art. Six of her portraits can be found in the monumental painting ensembles of the Serbian medieval monasteries of Sopoćani, Gradac, Arilje, Đurđevi Stupovi (Pillars of St. George), and Gračanica, as well as on two icons and one seal. Queen Helen is also the only female Serbian medieval ruler whose vita was included in the famous collection of the “Lives of Serbian Kings and Archbishops” by Archbishop Danilo II, a prominent church leader, warrior, and writer.
Acceptance of New Land-Use Activities by Hmong and Khmu Ethnic Groups: A Case Study in Northern Lao People’s Democratic Republic
Authors: Kobayashi Natsuko , Bounithiphonh Chaloun , Sichanthongthip Phonevilay , Phongoudome Chanhsamone , Hiratsuka Motoshi
Published: December 2021

Reducing emissions from deforestation and forest degradation (REDD+) to address climate change has historically included little evaluation of how heterogeneous local communities respond to REDD+ interventions and new land-use activities. We assessed differences in the acceptance of new land-use activities as a function of livelihoods of the Hmong and Khmu ethnic groups in northern Lao People’s Democratic Republic, where REDD+ was implemented between 2011 and 2018. Our socioeconomic data, collected by a questionnaire-based survey and focal group discussions, showed that the Hmong more effectively incorporated support from REDD+ than the Khmu because the Hmong owned grazing land. Our findings highlight the importance of understanding the capabilities and characteristics of each ethnic group when implementing new land-use activities (i.e., designing and implementing alternative livelihoods) within a target area to ensure distributional equity in heterogeneous communities. Such a consideration should be included in land-use policy and also be a part of the social safeguards in the land-use sector.
Liquid Chromatographic/Mass Spectrometric Study on the Role of Beech (Fagus sylvatica L.) Wood Polyphenols in Red Heartwood Formation
Authors: Hofmann Tamás , Guran Roman , Zitka Ondrej , Visi-Rajczi Eszter , Albert Levente
Published: December 2021

The present research focused on the analysis of European beech (Fagus sylvatica L.) wood polyphenols in respect to red heartwood formation, which is a significant color and technological defect of the species. For the first time, high-performance liquid chromatography/tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) were applied for the investigation of the structure and the radial distribution of polyphenols. Altogether 125 compounds were characterized by their MSn spectra, of which 71 were tentatively identified, including procyanidins (dimers to pentamers), flavonoids (taxifolin, naringenin, isorhamnetin, (epi)afzelechin), (+)-catechin, (−)-epicatechin) and their glycoside conjugates, phenolic acids (gallic acid, vanillic acid, syringic acid) and their glycosides as well as gallic acid derivatives, many of which were identified for the first time in beech wood. It was found that the concentration of many compounds increased at the color boundary. In situ polyphenol synthesis and metabolism were clearly evidenced at the color boundary. Red heartwood contained only free aglycones (syringic acid, taxifolin, naringenin, isorhamnetin, naringenin, syringic acid). Contrary to earlier assumptions, the MALDI-TOF analysis did not indicate the presence of oxidized high-molecular-weight polymeric polyphenols in the red heartwood tissues. The role of individual compounds in the formation of the red heartwood chromophores are discussed.
Forest Transformation in the Wake of Colonization: The Quijos Andean Amazonian Flank, Past and Present
Authors: Sarmiento Fausto O. , Rodríguez Jack , Yepez-Noboa Alden
Published: December 2021

Forest transformation modified the Quijos’ ancient mountainscapes in three ways: scientific approximation, entrepreneurial investing, and community engagement. We concentrate the study in the Cumandá Protected Forest reserve as exemplar in the Quijos valley. Our objective is to understand forest transition trends and prospects of sustainability by answering qualitative research questions of impact on cloud forest vegetation from a socioecological standpoint. We used ethnographic work, personal interviews, surveys to the community, and queries to authorities; our qualitative methods included critical discourse analyses, onomastic interpretation, and matrix comparison for ecological legacies, focused on three sectors of the economy that we posit impacted these forests, all indicative of a more competitive, globalized framework: forest tourism, retreating forest frontier, and mining forested watersheds. We found that these sectors also helped alleviate poverty in local communities so that ecotourism, non-traditional forest product harvest, and subsistence mining of water could become stewards, despite the fact that such a nuanced approach has not yet been fully implemented by local governments. We conclude that Hostería Cumandá promotes new conservation narratives in positive ways, since it fuels grassroots organizations to incorporate nature conservation into restoration ecology efforts, provides studies on mountain forest species of concern in the area, generates local employment, and converts a transitory, ephemeral attraction into an international tourism destination.
Application of Machine Learning Techniques to Predict a Patient’s No-Show in the Healthcare Sector
Authors: Salazar Luiz Henrique A. , Leithardt Valderi R. Q. , Parreira Wemerson Delcio , da Rocha Fernandes Anita M. , Barbosa Jorge Luis Victória , Correia Sérgio Duarte
Published: December 2021

The health sector faces a series of problems generated by patients who miss their scheduled appointments. The main challenge to this problem is to understand the patient’s profile and predict potential absences. The goal of this work is to explore the main causes that contribute to a patient’s no-show and develop a prediction model able to identify whether the patient will attend their scheduled appointment or not. The study was based on data from clinics that serve the Unified Health System (SUS) at the University of Vale do Itajaí in southern Brazil. The model obtained was tested on a real collected dataset with about 5000 samples. The best model result was performed by the Random Forest classifier. It had the best Recall Rate (0.91) and achieved an ROC curve rate of 0.969. This research was approved and authorized by the Ethics Committee of the University of Vale do Itajaí, under opinion 4270,234, contemplating the General Data Protection Law.
Fish Diversity Monitored by Environmental DNA in the Yangtze River Mainstream
Authors: Jia Hui , Zhang Hui , Xian Weiwei
Published: December 2021

Surveys and assessments based on environmental DNA are not only efficient and time-saving, but also cause less harm to monitoring targets. Environmental DNA has become a common tool for the assessment and monitoring of aquatic organisms. In this study, we investigated fish resources in the Yangtze River mainstream using environmental DNA, and the variations in fish during two seasons (spring and autumn) were compared. The results showed that 13 species were identified in spring, and nine species of fish were identified in autumn. The fish with higher eDNA detection were Sinibotia superciliaris, Tachysurus fulvidraco, Cyprinus carpio, Ctenopharyngodon Idella, Monopterus albus, Acanthogobius hasta, Saurogobio dabryi, Oncorhynchus mykiss, Mugil cephalus, Odontamblyopus rubicundus. Seasonal variation between spring and autumn was not significant, and the environmental factors had different effects on fish assemblages during the two seasons. Our study used the eDNA technique to monitor the composition of fish in the spring and autumn in the Yangtze River mainstream, providing a new technology for the long-term management and protection of fishery resources in the region. Of course, problems such as pollution and insufficient databases are the current shortcomings of environmental DNA, which will be the focus of our future research and study.
A New Anisotropic Four-Parameter Turbulence Model for Low Prandtl Number Fluids
Authors: Barbi Giacomo , Giovacchini Valentina , Manservisi Sandro
Published: December 2021

Due to their interesting thermal properties, liquid metals are widely studied for heat transfer applications where large heat fluxes occur. In the framework of the Reynolds-Averaged Navier–Stokes (RANS) approach, the Simple Gradient Diffusion Hypothesis (SGDH) and the Reynolds Analogy are almost universally invoked for the closure of the turbulent heat flux. Even though these assumptions can represent a reasonable compromise in a wide range of applications, they are not reliable when considering low Prandtl number fluids and/or buoyant flows. More advanced closure models for the turbulent heat flux are required to improve the accuracy of the RANS models dealing with low Prandtl number fluids. In this work, we propose an anisotropic four-parameter turbulence model. The closure of the Reynolds stress tensor and turbulent heat flux is gained through nonlinear models. Particular attention is given to the modeling of dynamical and thermal time scales. Numerical simulations of low Prandtl number fluids have been performed over the plane channel and backward-facing step configurations.
In Vitro Immuno-Modulatory Potentials of Purslane (Portulaca oleracea L.) Polysaccharides with a Chemical Selenylation
Authors: Lin Ya-Ru , Guan Qing-Yun , Li Ling-Yu , Tang Zhi-Mei , Zhang Qiang , Zhao Xin-Huai
Published: December 2021

The soluble polysaccharides from a non-conventional and edible plant purslane (Portulaca oleracea L.), namely PSPO, were prepared by the water extraction and ethanol precipitation methods in this study. The obtained PSPO were selenylated using the Na2SeO3-HNO3 method to successfully prepare two selenylated products, namely SePSPO-1 and SePSPO-2, with different selenylation extents. The assay results confirmed that SePSPO-1 and SePSPO-2 had respective Se contents of 753.8 and 1325.1 mg/kg, while PSPO only contained Se element about 80.6 mg/kg. The results demonstrated that SePSPO-1 and SePSPO-2 had higher immune modulation than PSPO (p < 0.05), when using the two immune cells (murine splenocytes and RAW 264.7 macrophages) as two cell models. Specifically, SePSPO-1 and SePSPO-2 were more active than PSPO in the macrophages, resulting in higher cell proliferation, greater macrophage phagocytosis, and higher secretion of the immune-related three cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β. Meanwhile, SePSPO-1 and SePSPO-2 were more potent than PSPO in the concanavalin A- or lipopolysaccharide-stimulated splenocytes in cell proliferation, or more able than PSPO in the splenocytes to promote interferon-γ secretion but suppress IL-4 secretion, or more capable of enhancing the ratio of T-helper (CD4+) cells to T-cytotoxic (CD8+) cells for the T lymphocytes than PSPO. Overall, the higher selenylation extent of the selenylated PSPO mostly caused higher immune modulation in the model cells, while a higher polysaccharide dose consistently led to the greater regulation effect. Thus, it is concluded that the employed chemical selenylation could be used in the chemical modification of purslane or other plant polysaccharides, when aiming to endow the polysaccharides with higher immuno-modulatory effect on the two immune cells.
Semidefinite Multiobjective Mathematical Programming Problems with Vanishing Constraints Using Convexificators
Authors: Lai Kin Keung , Hassan Mohd , Singh Sanjeev Kumar , Maurya Jitendra Kumar , Mishra Shashi Kant
Published: December 2021

In this paper, we establish Fritz John stationary conditions for nonsmooth, nonlinear, semidefinite, multiobjective programs with vanishing constraints in terms of convexificator and introduce generalized Cottle type and generalized Guignard type constraints qualification to achieve strong S—stationary conditions from Fritz John stationary conditions. Further, we establish strong S—stationary necessary and sufficient conditions, independently from Fritz John conditions. The optimality results for multiobjective semidefinite optimization problem in this paper is related to two recent articles by Treanta in 2021. Treanta in 2021 discussed duality theorems for special class of quasiinvex multiobjective optimization problems for interval-valued components. The study in our article can also be seen and extended for the interval-valued optimization motivated by Treanta (2021). Some examples are provided to validate our established results.
Finding Rare Quasars: VLA Snapshot Continuum Survey of FRI Quasar Candidates Selected from the LOFAR Two-Metre Sky Survey (LoTSS)
Authors: Gürkan Gülay , Croston Judith , Hardcastle Martin J. , Mahatma Vijay , Mingo Beatriz , Williams Wendy L.
Published: December 2021

The radiative and jet power in active galactic nuclei is generated by accretion of material on to supermassive galactic-centre black holes. For quasars, where the radiative power is by definition very high, objects with high radio luminosities form 10 per cent of the population, although it is not clear whether this is a stable phase. Traditionally, quasars with high radio luminosities have been thought to present jets with edge-brightened morphology (Fanaroff-Riley II—FR II) due to the limitations of previous radio surveys (i.e., FRIs were not observed as part of the quasar population). The LOw Frequency ARray (LOFAR) Two-metre Sky Survey (LoTSS) with its unprecedented sensitivity and resolution covering wide sky areas has enabled the first systematic selection and investigation of quasars with core-brightened morphology (Fanaroff-Riley I—FR). We carried out a Very Large Array (VLA) snapshot survey to reveal inner structures of jets in selected quasar candidates; 15 (25 per cent) out of 60 sources show clear inner jet structures that are diagnostic of FRI jets and 13 quasars (∼22 per cent) show extended structures similar to those of FRI jets. Black hole masses and Eddington ratios do not show a clear difference between FRI and FRII quasars. FRII quasars tend to have higher jet powers than FRI quasars. Our results show that the occurrence of FRI jets in powerful radiatively efficient systems is not common, probably mainly due to two factors: galaxy environment and jet power.
Acid-Catalyzed Water Extraction of Two Polysaccharides from Artemisia argyi and Their Physicochemical Properties and Antioxidant Activities
Authors: Ruan Yuan , Niu Chaofei , Zhang Pengzhan , Qian Yanyan , Li Xinxin , Wang Li , Ma Bingji
Published: December 2021

In this study, two purified polysaccharide fractions, Artp1 and Artp2, were obtained using acid-catalyzed water extraction, and then purified by DEAE-52 cellulose and Sephadex G-200 column chromatography from the crude polysaccharides of Artemisia argyi. Their physicochemical properties were investigated by gel permeation chromatography (GPC), high-performance anion exchange chromatography (HPAEC), Fourier transform infrared (FT-IR), scanning electron microscope (SEM), thermal analysis, and methylation analysis. The average molecular weight (Mw) of Artp1 and Artp2 were estimated to be 42.17 kDa and 175.22 kDa, respectively. Monosaccharide composition analysis revealed that the Rha, Gal, and GalA occupied main proportion in Artp1 with the molar ratio of 25.1:24.7:40.4, while the Rha, Gal, Xly, and GalA occupied the main proportion in Artp2 with the molar ratio of 16.7:13.5:12.8:38.7. Due to the high yield and the relatively high carbohydrate content, the Artp1 was determined by the methylation analysis and NMR. The results of Artp1 indicated that 1,4-GalpA and 1,2,4-Rhap formed the backbone with some 1,2-Rhap, 1,3-Galp, and 1,6-Galp in the backbone or the side chains. Artp1 and Artp2 exhibited effective antioxidant activities by DPPH radical scavenging assay and hydroxyl radical scavenging assay in a dose-dependent manner. These investigations of the polysaccharides from A. argyi. provide a scientific basis for the uses of Artp1 and Artp2 as ingredients in functional foods and medicines.
Genome-Wide Identification and Characterization of HSP70 Gene Family in Aquilaria sinensis (Lour.) Gilg
Authors: Yu Cuicui , Rong Mei , Liu Yang , Sun Peiwen , Xu Yanhong , Wei Jianhe
Published: December 2021

The heat shock protein 70 (HSP70) gene family perform a fundamental role in protecting plants against biotic and abiotic stresses. Aquilaria sinensis is a classic stress-induced medicinal plant, producing a valuable dark resin in a wood matrix, known as agarwood, in response to environmental stresses. The HSP70 gene family has been systematic identified in many plants, but there is no comprehensive analysis at the genomic level in A. sinensis. In this study, 15 putative HSP70 genes were identified in A. sinensis through genome-wide bioinformatics analysis. Based on their phylogenetic relationships, the 15 AsHSP70 were grouped into six sub-families that with the conserved motifs and gene structures, and the genes were mapped onto six separate linkage groups. A qRT-PCR analysis showed that the relative expression levels of all the AsHSP70 genes were up-regulated by heat stress. Subcellular localization of all HSP70s was predicted, and three were verified by transiently expressed in Arabidopsis protoplasts. Based on the expression profiles in different tissues and different layers treated with Agar-Wit, we predict AsHSP70 genes are involved in different stages of agarwood formation. The systematic identification and expression analysis of HSP70s gene family imply some of them may play important roles in the formation of agarwood. Our findings not only provide a foundation for further study their biological function in the later research in A. sinensis, but also provides a reference for the analysis of HSPs in other species.
DARTS: An Algorithm for Domain-Associated Retrotransposon Search in Genome Assemblies
Authors: Biryukov Mikhail , Ustyantsev Kirill
Published: December 2021

Retrotransposons comprise a substantial fraction of eukaryotic genomes, reaching the highest proportions in plants. Therefore, identification and annotation of retrotransposons is an important task in studying the regulation and evolution of plant genomes. The majority of computational tools for mining transposable elements (TEs) are designed for subsequent genome repeat masking, often leaving aside the element lineage classification and its protein domain composition. Additionally, studies focused on the diversity and evolution of a particular group of retrotransposons often require substantial customization efforts from researchers to adapt existing software to their needs. Here, we developed a computational pipeline to mine sequences of protein-coding retrotransposons based on the sequences of their conserved protein domains—DARTS (Domain-Associated Retrotransposon Search). Using the most abundant group of TEs in plants—long terminal repeat (LTR) retrotransposons (LTR-RTs)—we show that DARTS has radically higher sensitivity for LTR-RT identification compared to the widely accepted tool LTRharvest. DARTS can be easily customized for specific user needs. As a result, DARTS returns a set of structurally annotated nucleotide and amino acid sequences which can be readily used in subsequent comparative and phylogenetic analyses. DARTS may facilitate researchers interested in the discovery and detailed analysis of the diversity and evolution of retrotransposons, LTR-RTs, and other protein-coding TEs.
Tsunamis in the Greek Region: An Overview of Geological and Geomorphological Evidence
Authors: Karkani Anna , Evelpidou Niki , Tzouxanioti Maria , Petropoulos Alexandros , Gogou Marilia , Mloukie Eleni
Published: December 2021

The Greek region is known as one of the most seismically and tectonically active areas and it has been struck by some devastating tsunamis, with the most prominent one being the 365 AD event. During the past decade significant research efforts have been made in search of geological and geomorphological evidence of palaeotsunamis along the Greek coasts, primarily through the examination of sediment corings (72% of studies) and secondarily through boulders (i.e., 18%). The published data show that some deposits have been correlated with well-known events such as 365 AD, 1303 AD, the Minoan Santorini Eruption and the 1956 Amorgos earthquake and tsunami, while coastal studies from western Greece have also reported up to five tsunami events, dating as far back as the 6th millennium BC. Although the Ionian Islands, Peloponnese and Crete has been significantly studied, in the Aegean region research efforts are still scarce. Recent events such as the 1956 earthquake and tsunami and the 2020 Samos earthquake and tsunami highlight the need for further studies in this region, to better assess the impact of past events and for improving our knowledge of tsunami history. As Greece is amongst the most seismically active regions globally and has suffered from devastating tsunamis in the past, the identification of tsunami prone areas is essential not only for the scientific community but also for public authorities to design appropriate mitigation measures and prevent tsunami losses in the future.
The Geochemical and Isotopic Record of Wilson Cycles in Northwestern South America: From the Iapetus to the Caribbean
Authors: Spikings Richard , Van der Lelij Roelant
Published: December 2021

Isotopic and geochemical data delineate passive margin, rift and active margin cycles in northwestern South America since ~623 Ma, spanning from the Iapetus Wilson Cycle. Ultramafic and mafic rocks record rifting associated with the formation of the Iapetus Ocean during 623–531 Ma, while the initiation of subduction of the Iapetus and Rheic oceans is recorded by continental arc plutons that formed during 499–414 Ma, with alternating compressive and extensional stages. Muscovite 40Ar/39Ar dates suggest there may have been a phase of Carboniferous metamorphism, although this remains tentative. A Passive margin was modified by active margin magmatism that started at ~294 Ma and culminated with collisional tectonics that signaled the final stages of the amalgamation of western Pangaea. Early Pangaea fragmentation included back-arc rifting during 245–216 Ma, leading to a Pacific active margin that spanned from 213–115 Ma. Trench retreat accelerated during 144–115 Ma, forming a highly attenuated continental margin prior to the collision of the Caribbean Large Igneous Province at ~75 Ma.
Exploring the Feelings of Nurses during Resuscitation—A Cross-Sectional Study
Authors: Koželj Anton , Šikić Pogačar Maja , Fijan Sabina , Strauss Maja , Poštuvan Vita , Strnad Matej
Published: December 2021

Cardiopulmonary resuscitation (CPR) is one of the most stressful situations in emergency medicine. Nurses involved in performing basic and advanced resuscitation procedures are therefore exposed to a certain amount of stress. The purpose of this study was to determine the stressors and the level of stress experienced by nurses during resuscitation. A cross-sectional quantitative study was done. The sample consisted of 457 nurses who worked in emergency units. First demographic data were collected, followed by a questionnaire regarding the effect of different situations that occur during and after resuscitation on nurses including Post-Code Stress Scale questionnaire. The most disturbing situations for respondents were resuscitation of young person (MV = 3.7, SD = 1.4), when they fail to establish an intravenous pathway (MV = 3.5, SD = 1.4), chaotic situation during resuscitation (MV = 3.4, SD = 1.4) and making decision about termination of resuscitation (MV = 3.1, SD = 1.5). Research has shown that nurses are exposed to a certain amount of stress during resuscitation, but most of them manage to compensate for stress effectively.
Knowledge, Attitude, and Practice of Intranasal Corticosteroid in Allergic Rhinitis Patients: Development of a New Questionnaire
Authors: Retinasekharan Senthilraj , Md Shukri Norasnieda , Ismail Ahmad Filza , Abdullah Baharudin
Published: December 2021

Objectives: The knowledge gap and attitude of allergic rhinitis (AR) patients using intranasal corticosteroid (INCS) led to the poor outcome of their disease. We aimed to develop and validate a new questionnaire to assess the knowledge, attitude, and practice (KAP) of AR patients that can be used to assess and understand the factors affecting compliance of INCS. Methods: The questionnaire comprised development and validation stages. A self-administered questionnaire was developed after a comprehensive literature review. It was subjected to content and face validity before a revised final version was drafted. Exploratory factor analysis was used to assess the validity of the questionnaire. Cronbach’s alpha was used to verify internal consistency. Results: The development phase resulted in a questionnaire consisting of 14 items. Explanatory factor analysis revealed four factors associated with KAP. The four factors were extracted, and 12 items were kept. The factors were attitude domain with four items (factor 1), practice domain with four items (factor 2), and knowledge domain with four items (factor 3 has two items, and factor 4 has two items). The Cronbach’s alpha of the four factors ranged from 0.614 to 0.809. The final questionnaire consists of 3 domains with 12 items (the knowledge domain with four questions; the attitude domain with four questions; the practice domain with four questions) and was valid and reliable. Conclusions: The newly developed questionnaire has adequate validity and reliability. It is a useful tool to improve the treatment of AR patients by understanding the factors affecting their compliance.
Immunotherapy in Myeloma: A Theme Issue in Honor of Prof. Dr. Gösta Gahrton
Authors: Kröger Nicolaus , Garderet Laurent
Published: December 2021

Immunotherapy has become a major pillar in the treatment of multiple myeloma [...]
A Novel Target (Oxidation Resistant 2) in Arabidopsis thaliana to Reduce Clubroot Disease Symptoms via the Salicylic Acid Pathway without Growth Penalties
Authors: Mencia Regina , Welchen Elina , Auer Susann , Ludwig-Müller Jutta
Published: December 2021

The clubroot disease (Plasmodiophora brassicae) is one of the most damaging diseases worldwide among brassica crops. Its control often relies on resistant cultivars, since the manipulation of the disease hormones, such as salicylic acid (SA) alters plant growth negatively. Alternatively, the SA pathway can be increased by the addition of beneficial microorganisms for biocontrol. However, this potential has not been exhaustively used. In this study, a recently characterized protein Oxidation Resistant 2 (OXR2) from Arabidopsis thaliana is shown to increase the constitutive pathway of SA defense without decreasing plant growth. Plants overexpressing AtOXR2 (OXR2-OE) show strongly reduced clubroot symptoms with improved plant growth performance, in comparison to wild type plants during the course of infection. Consequently, oxr2 mutants are more susceptible to clubroot disease. P. brassicae itself was reduced in these galls as determined by quantitative real-time PCR. Furthermore, we provide evidence for the transcriptional downregulation of the gene encoding a SA-methyltransferase from the pathogen in OXR2-OE plants that could contribute to the phenotype.
Assessing the Potential of Sentinel-2 Derived Vegetation Indices to Retrieve Phenological Stages of Mango in Ghana
Authors: Torgbor Benjamin Adjah , Rahman Muhammad Moshiur , Robson Andrew , Brinkhoff James , Khan Azeem
Published: December 2021

In 2020, mango (Mangifera indica) exports contributed over 40 million tons, worth around US$20 billion, to the global economy. Only 10% of this contribution was made from African countries including Ghana, largely due to lower investment in the sector and general paucity of research into the mango value chain, especially production, quality and volume. Considering the global economic importance of mango coupled with the gap in the use of the remote sensing technology in the sector, this study tested the hypothesis that phenological stages of mango can be retrieved from Sentinel-2 (S2) derived time series vegetation indices (VIs) data. The study was conducted on four mango farms in the Yilo Krobo Municipal Area of Ghana. Seasonal (temporal) growth curves using four VIs (NDVI, GNDVI, EVI and SAVI) for the period from 2017 to 2020 were derived for each of the selected orchards and then aligned with five known phenology stages: Flowering/Fruitset (F/FS), Fruit Development (FRD), Maturity/Harvesting (M/H), Flushing (FLU) and Dormancy (D). The significance of the variation “within” and “between” farms obtained from the VI metrics of the S2 data were tested using single-factor and two-factor analysis of variance (ANOVA). Furthermore, to identify which specific variable pairs (phenology stages) were significantly different, a Tukey honest significant difference (HSD) post-hoc test was conducted, following the results of the ANOVA. Whilst it was possible to differentiate the phenological stages using all the four VIs, EVI was found to be the best related with p < 0.05 for most of the studied farms. A distinct annual trend was identified with a peak in June/July and troughs in December/January. The derivation of remote sensing based ‘time series’ growth profiles for commercial mango orchards supports the ‘benchmarking’ of annual and seasonal orchard performance and therefore offers a near ‘real time’ technology for identifying significant variations resulting from pest and disease incursions and the potential impacts of seasonal weather variations.
Urban Stormwater Resilience Assessment Method Based on Cloud Model and TOPSIS
Authors: Qiao Han , Pei Jingjing
Published: December 2021

To scientifically and quantitatively evaluate the degree of urban storm resilience and improve the level of urban stormwater resilience, based on the resilience theory, starting from the three attributes of resilience (resistance, recovery and adaptability), this paper establishes the framework of urban resilience evaluation indicator system under the background of stormwater disaster. Firstly, the weight of the indicator system is analyzed by the Delphi method and cloud model, and then the urban stormwater recilience evaluation model is constructed by using the cloud model and approximate ideal solution ranking method. Through the fuzzy description, the corresponding quantitative value is given to the qualitative indicator, so that the stormwater resilience of the city can be measured by accurate values. Finally, the feasibility of the model is verified by case analysis. The results show that the urban stormwater resilience evaluation theory and method based on cloud model and approximate ideal solution ranking method have important guiding significance to improve the level of urban stormwater resilience.
Handgrip Strength to Predict the Risk of All-Cause and Premature Mortality in Korean Adults: A 10-Year Cohort Study
Authors: Kim Junghoon
Published: December 2021

The prospective association of muscular weakness with the risk of all-cause and premature mortality in a general population remains unknown. The aim of this study was to investigate the prospective effects of handgrip strength and muscular weakness on risk for all-cause and premature mortality over 10 years using a large nationwide sample of Korean adults. The study participants included 9229 middle and older adults (4131 males and 5098 females), using data from the Korean Longitudinal Study of Ageing 2006–2016. Muscular strength was measured using handgrip strength. Muscle weakness was defined using the sex-specific handgrip strength index based on the Asian Working Group on Sarcopenia in Older People (AWGSOP). The primary outcome was all-cause and premature mortality assessed based on the death certificate. The hazard ratio (HR) for all-cause mortality was negatively associated with level of handgrip strength independent of potential confounding factors (HR: 2.06, 95% confidence interval [CI]: 1.62–2.63 for lowest quartile vs. highest quartile). When examined using muscle weakness defined using the AWGSOP diagnosis, the mortality was 1.56 times higher in the weak group (HR: 1.56, 95% CI: 1.36–1.78). We also found that risk of premature mortality was observed in the lowest quartile (HR: 2.34, 95% CI: 1.80–3.05) and the muscle weakness group (HR: 1.80, 95% CI: 1.52–2.13) in the fully adjusted model. Our 10-year prospective cohort study showed that handgrip strength and muscle weakness are strongly associated with an increased risk of all-cause and premature mortality in healthy middle-aged and older adults.
Exploratory Case Study of Suicide among a Sample of 9/11 Survivors
Authors: Seil Kacie , Takemoto Erin , Farfel Mark R. , Huynh Mary , Li Jiehui
Published: December 2021

Background: Previous research has found higher than expected suicide mortality among rescue/recovery workers (RRWs) enrolled in the World Trade Center Health Registry (WTCHR). Whether any enrollee suicides are related to the decedents’ experiences on 9/11 is unknown. We abstracted medical examiner file data to learn more about 9/11-related circumstances of suicides among WTCHR enrollees. Methods: We identified 35 enrollee suicide cases that occurred in New York City using linked vital records data. We reviewed medical examiner files on each case, abstracting demographic and circumstantial data. We also reviewed survey data collected from each case at WTCHR enrollment (2003–2004) and available subsequent surveys to calculate descriptive statistics. Results: Cases were mostly non-Hispanic White (66%), male (83%), and middle-aged (median 58 years). Nineteen decedents (54%) were RRWs, and 32% of them worked at the WTC site for >90 days compared to 18% of the RRW group overall. In the medical examiner files of two cases, accounts from family mentioned 9/11-related circumstances, unprompted. All deaths occurred during 2004–2018, ranging from one to four cases per year. Leading mechanisms were hanging/suffocation (26%), firearm (23%), and jump from height (23%). Sixty percent of the cases had depression mentioned in the files, but none mentioned posttraumatic stress disorder. Conclusions: RRWs may be at particular risk for suicide, as those who worked at the WTC site for long periods appeared to be more likely to die by suicide than other RRWs. Mental health screening and treatment must continue to be prioritized for the 9/11-exposed population. More in-depth investigations of suicides can elucidate the ongoing impacts of 9/11.
Prevalence of SARS-CoV-2 Infection in a Sample of Health Workers in Two Health Departments of the Valencian Community in Spain
Authors: Rodríguez de Limia Ramírez Kenan , Ruiz-Robledillo Nicolás , Duro-Torrijos José Luis , García-Román Vicente , Albaladejo-Blázquez Natalia , Ferrer-Cascales Rosario
Published: December 2021

Health care personnel constitutes the most vulnerable group of professionals, as they are employed in a work context with higher exposure to SARS-CoV-2 infection. This study aims to estimate the prevalence of SARS-CoV-2 infection in health personnel (n = 2858) of two health departments in the Valencian community between March 2020 and April 2021, as well as the sociodemographic and work variables predicting higher infection prevalence in this group. A cross-sectional descriptive study was performed on health workers from the health departments of Torrevieja and Elche-Crevillente of the Valencian Community (Spain). After obtaining the samples, the cases were identified through an active infection diagnostic test (AIDT). The analyzed variables were: sex, age (18–34/35–49/>50 years), professional category, health care, risk service, and AIDT. A total of 2858 staff members were studied. Of them, 55.4% (1582) underwent an AIDT, with 9.7% (277) of positive cases. Infection predominated in the age group of 18 to 34 years, 12.6% (OR = 1.98, 95% CI [1.26, 3.11]); nurses, 12.1% (OR = 1.5, 95% CI [1.00, 2.23]); and at-risk services, 11.4% (OR = 1.3, 95% CI [1.06, 1.81]). A very low positivity rate was identified in the health personnel linked to the health departments analyzed during the 14 months of the study period. Based on our results, prevention strategies could focus more intensively on the most at-risk groups, specifically young nurses who work in at-risk services, mainly in emergency and internal medicine.
Maternal Attachment Representations during Pregnancy, Perinatal Maternal Depression, and Parenting Stress: Relations to Child’s Attachment
Authors: Sechi Cristina , Prino Laura Elvira , Rollé Luca , Lucarelli Loredana , Vismara Laura
Published: December 2021

Background: This paper aimed to explore the associations between maternal representations of attachment evaluated during pregnancy, pre and postnatal maternal depression, parenting stress and child’s attachment at 15 months after childbirth. Methods: Mothers (n = 71), and their infants participated in a longitudinal study of maternal attachment, pre and postnatal depression, parenting stress and child attachment. Adult Attachment Interview (AAI) was conducted between 24 and 26 weeks of pregnancy (Time 1), depression was assessed using the Edinburgh Perinatal Depression Scale (EPDS) (at Time 1 and 6 months after childbirth, i.e., Time 2), parenting stress was assessed using the Parenting Stress Index—Short Form (PS-SF) (at Time 2) and the Strange Situation Procedure (SSP) at child’s 15 months of age (Time 3). Results: Free-autonomous maternal classification of attachment increases the likelihood of secure child classification in her offspring, while decreases that of avoidance and ambivalence. Insecure maternal representation of attachment evaluated during pregnancy and higher levels of parenting stress at six months after childbirth was associated with higher rates of infant insecure attachment at 15 months. Conclusions: Our study validates the importance of considering maternal representations of attachment crucial in determining the quality of the caregiving environment, thereby the healthy development of children, despite the presence of other contextual risk.
Ethnic Composition of Couples and Mutual Health Benefit Receipt: Register-Based Evidence from Finland
Authors: Saarela Jan , Stanfors Maria , Rostila Mikael
Published: December 2021

The literature on health dependencies among partners typically ignores diversity of partnership characteristics. One salient example is the ethnic composition. We extend prior work on partnerships and health by investigating how married and cohabiting partners mutually influence each other’s receipt of health-related benefits, focusing on how such correlations vary with the couple’s ethnic composition. We study partners’ mutual receipt of sickness allowance and disability pension in ethnically endogamous and exogamous couples in Finland. The population consists of native individuals in similar socioeconomic positions but belonging to two different ethnic groups—Finnish and Swedish speakers—who differ in health and family life. Using data from population registers, we estimate discrete-time hazard models for first-time benefit receipt, as related to partner’s benefit receipt, among midlife couples. We found evidence of mutual receipt of health benefits in both endogamous and exogamous couples, the correlation being strongest for disability pension. Partner correlation in disability pension receipt is slightly stronger in endogamous Swedish than in endogamous Finnish couples, while women in exogamous couples are slightly less sensitive to men’s receipt than vice versa. The results show that mutual health may be heterogeneous across couples that differ in ethnic composition.
Association between Parenthood and Health Behaviour in Later Life—Results from the Population-Based CARLA Study
Authors: Becker Lisa , Negash Sarah , Kartschmit Nadja , Kluttig Alexander , Mikolajczyk Rafael
Published: December 2021

Previous research has focused on comparing health behaviour between parents and non-parents at younger ages, while little is known about the impact of being a parent on health behaviours in later life. We studied whether parenthood is associated with later physical activity (PA), dietary pattern, smoking status and alcohol consumption in German adults of middle and old age. We used data from the baseline examination of the population-based CARLA-study in Halle (Saale), comprising 1779 adults aged 45–83. Linear and logistic regression analyses assessed the relationship between parenthood and health behaviours while controlling for age, partner status, education, income, occupational position, socioeconomic status in childhood, and number of chronic diseases. Of the participants, 89.1% had biological children. Being a father was associated with higher PA in sports (sport index ß = 0.29, 95% confidence interval [0.14; 0.44]), but not with PA in leisure time (excluding sports), dietary pattern, consumption of alcohol and smoking status. No associations were found between being a mother with all outcome variables. Provided that PA of fathers is typically reduced when the children are young, the development towards higher PA at later age needs to be studied in more detail.
Effects of Attentional Focus on Muscular Endurance: A Meta-Analysis
Authors: Grgic Jozo , Mikulic Pavle
Published: December 2021

Several studies explored the effects of attentional focus on resistance exercise, but their analysed outcomes most commonly involved surface electromyography variables. Therefore, the effects of attentional focus on resistance exercise performance remain unclear. The aim of this review was to perform a meta-analysis examining the acute effects of external focus vs. internal focus vs. control on muscular endurance. Five databases were searched to find relevant studies. The data were pooled in a random-effects meta-analysis. In the analysis for external vs. internal focus of attention, there were seven comparisons with 14 study groups. In the analyses for external focus vs. control and internal focus vs. control, there were six comparisons with 12 study groups. An external focus of attention enhanced muscular endurance when compared with an internal focus (Cohen’s d: 0.58; 95% confidence interval (CI): 0.34 and 0.82) and control (Cohen’s d: 0.42; 95% CI: 0.08 and 0.76). In the analysis for internal focus vs. control, there was no significant difference between the conditions (Cohen’s d: –0.19; 95% CI: –0.45 and 0.07). Generally, these results remained consistent in the subgroup analyses for upper-body vs. lower-body exercises. From a practical perspective, the results presented in this review suggest that individuals should use an external focus of attention for acute enhancement of muscular endurance.
Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model
Authors: Soliman Eman , Bhalla Sophia , Elhassanny Ahmed E. M. , Malur Anagha , Ogburn David , Leffler Nancy , Malur Achut G. , Thomassen Mary Jane
Published: December 2021

The use of carbon nanotubes has increased in the past few decades. Carbon nanotubes are implicated in the pathogenesis of pulmonary sarcoidosis, a chronic granulomatous inflammatory condition. We developed a murine model of chronic granulomatous inflammation using multiwall carbon nanotubes (MWCNT) to investigate mechanisms of granuloma formation. Using this model, we demonstrated that myeloid deficiency of ATP-binding cassette (ABC) cholesterol transporter (ABCG1) promotes granuloma formation and fibrosis with MWCNT instillation; however, the mechanism remains unclear. Our previous studies showed that MWCNT induced apoptosis in bronchoalveolar lavage (BAL) cells of wild-type (C57BL/6) mice. Given that continual apoptosis causes persistent severe lung inflammation, we hypothesized that ABCG1 deficiency would increase MWCNT-induced apoptosis thereby promoting granulomatous inflammation and fibrosis. To test our hypothesis, we utilized myeloid-specific ABCG1 knockout (ABCG1 KO) mice. Our results demonstrate that MWCNT instillation enhances pulmonary fibrosis in ABCG1 KO mice compared to wild-type controls. Enhanced fibrosis is indicated by increased trichrome staining and transforming growth factor-beta (TGF-β) expression in lungs, together with an increased expression of TGF-β related signaling molecules, interleukin-13 (IL-13) and Smad-3. MWCNT induced more apoptosis in BAL cells of ABCG1 KO mice. Initiation of apoptosis is most likely mediated by the extrinsic pathway since caspase 8 activity and Fas expression are significantly higher in MWCNT instilled ABCG1 KO mice compared to the wild type. In addition, TUNEL staining shows that ABCG1 KO mice instilled with MWCNT have a higher percentage of TUNEL positive BAL cells and more efferocytosis than the WT control. Furthermore, BAL cells of ABCG1 KO mice instilled with MWCNT exhibit an increase in efferocytosis markers, milk fat globule-EGF factor 8 (MFG-E8) and integrin β3. Therefore, our observations suggest that ABCG1 deficiency promotes pulmonary fibrosis by MWCNT, and this effect may be due to an increase in apoptosis and efferocytosis in BAL cells.