bluuebunny/crossref_metadata_2025 huggingface dataset:
Interlabial gap and freeway space at rest position: a cephalometric study
Authors: Seo Ye-Ji , Park Jae Hyun , Chang Na-Young , Seo Hye Young , Chae Jong-Moon
Published: October 2021

Objectives

The aim of this prospective study was to assess the amount of interlabial gap (ILG) and freeway space (FWS) at rest position (RP) according to gender, age, and skeletal pattern, and to evaluate the cephalometric measurements at maximum intercuspal position (MIP) and at RP to define the cephalometric changes from MIP to RP related to the amount of ILG and FWS.

Methods

Lateral cephalograms and photographs of selected subjects (47 females, 57 males) were obtained at MIP and RP. Cephalometric measurements at MIP and RP and their differences were measured and compared.

Results

ILG (P > 0.05) and FWS (P < 0.01) were greater in males than in females. ILG (P < 0.05) and FWS (P > 0.05) were greater in adolescents than in adults. ILG and FWS were not significantly related with the vertical skeletal pattern (FHR, facial height ratio). ILG was the greatest in Class II cases but without significance. FWS was significantly greater in Class III than in Class I and Class II cases (P < 0.05). At MIP, the ILG at RP increased as overjet (P < 0.05) and upper lip to the aesthetic line (P < 0.01) increased. At RP, the ILG increased as upper incisor exposure and the lips to the aesthetic line increased (P < 0.001), and FWS decreased as overbite decreased (P < 0.001). From MIP to RP, lip length showed the greatest decrease (P < 0.001) in the large ILG group. Additionally, Bjork sum (the sum of the saddle, articular, and gonial angles), mandibular plane angle, anterior facial height, and ANB (P < 0.001) showed the greatest increase, while OB (P < 0.001) showed the greatest decrease in the large FWS group. The lip competent group showed the largest frequency distribution in the small ILG and FWS groups, while smile line frequency distribution showed no relationship with the level of ILG and FWS.

Conclusions

Taking cephalometric measurements at RP would be helpful to evaluate the ILG and FWS more accurately, and to provide a more accurate diagnosis and treatment plan.
Heat transfer and the influence of electromagnetic field and thermal time during temperature distribution in human tissue
Authors: Lotfy Khaled , El-Bary Alla
Published: October 2021

The Penne’s bio-heat transfer equation can be used with normal mode technique to describe the characterizing of the temperature fluctuation in muscles. The analytical solutions of heating pattern is obtained in a closed-form when the propagation of ultrasonic waves in tissue system are taken into consideration. The impact of external electromagnetic field is used to investigate the influence of temporal and spatial distributions of temperature. The numerical simulations during the 2D and 3D graphs can be obtained for human tissue in simplified geometry in the context of the derived method. The normal mode analysis is used as a mathematical technique to solve the bioheat transfer equation analytically with some conditions to get the complete solution of the main variables in this model.
Vibration characteristics analysis and structural improvement of natural gas venting ignition pipeline
Authors: Chen Yong , Tan Jinjin , Tian Shuxian
Published: October 2021

In order to study the flow-induced vibration characteristics of the natural gas vent pipeline under the internal flow field, taking the gas transmission station pipeline as an example, the ANSYS Workbench software was used to establish models under two working conditions, uncoupling and fluid-solid coupling, for modal analysis, and analyze and compare the calculation results and propose a structural improvement plan. The results show that the maximum amplitude of the first three modes under the two working conditions is concentrated on the riser mouth, and the amplitude under the fluid-solid coupling condition is slightly larger than that of no coupling; the inner diameter of the pipe elbow is large and the pressure is small, and the outside diameter is small and the pressure is small. Large, this instability will increase the air pulsation of the flow field. In the improved scheme, adding a restriction on the top to increase the rigidity of the pipeline can significantly reduce the maximum amplitude of the gas pipeline; adding an orifice to eliminate air flow pulsation has a certain effect on reducing the maximum amplitude and natural frequency, and the combination of the two can make the pipeline more stable. The research results of this paper can provide improved ideas for vibration reduction at the natural gas venting operation site.
THE TSARIST IRON WORKS IN RUSSIA IN THE 17TH CENTURY
Authors: VАRENTSOVA Larisa Yu.
Published: October 2021

The palace manufacturing industry in Russia in the 17th century was represented by glass, morocco, linen, iron-making manufactories. They used the most advanced European technologies. Manufactories developed due to the exploitation of the population of the royal fiefdoms, soldiers, archers, domestic and foreign employees. Most of the products were intended for the needs of the royal family, a smaller one portion was used as sovereign grants and was bought up by the first-class nobility of Russia. A certain number of finished products were supplied to the domestic and international markets. The products of the palace iron works were exported abroad. At the same time, the organization of their activities in historical science remains virtually unexplored. The novelty of this article lies in the formulation of a scientific problem.
Here is the list of points that were covered in our research. The role of the tsarist iron works in the economy of the tsarist domain in Russia in the 17th century is determined. The main types of products of the palace iron-making manufactories are identified. The features of their functioning are studied. The article analyzes the conditions under which Dutch entrepreneurs rented tsarist iron works in the Russian state in the 17th century. Methods of providing industrial facilities with labor are shown. The significance of the Ministry of Secret Affairs in the organization of iron ore mining, which was in charge of the royal iron works, is determined. Their historical and geographical coordinates are indicated. The features of sales of finished products are covered. The evolution of the tsarist iron-making industry in Russia during the 17th century is explained.
In the palace fiefdoms, natural and human resources were used as much as possible. In the 17th century, in five districts of Russia (Maloyaroslavsky, Obolensky, Tula, Kashirsky, Moscow), the tsarist iron factories functioned. On which they used European experience in the use of production processes. Foreign specialists and entrepreneurs were invited to Russia. Dutch merchants A. Vinius, E. Vickens, P. Marselis, F. Akema, R. Adrian received a monopoly on the extraction of iron ore, the establishment of factories on unpopulated palace lands.
THE FRENCH IN ST. PETERSBURG IN THE LATE 19TH — EARLY 20TH CENTURIES. HISTORIOGRAPHY OF RECENT YEARS
Authors: Kupriyanova Angelina N.
Published: October 2021

The article provides an overview of historiography on the issue of the French presence in St. Petersburg in the late 19th — early 20th centuries. Without pretending to be an exhaustive list of publications on the stated topic, the author noted the most significant works of recent years. The main goal of the study is to trace the development of the views and interests of historians in the study of the French presence in the Northern capital. On the basis of the comparative historical method, an attempt is made to trace the creation of the image of the French immigrant by modern historians, as well as to restore the picture of the social, political, cultural and spiritual life of the French in St. Petersburg. The presented studies are devoted to the study of “French routes” in the city on the Neva, the French as a separate ethnic group and its assimilation, professional activity, periodicals in French and many other issues. Raising them, one can embark on the path of reconstruction of historical events. As one of the key conclusions, we fix that, despite the fact that sometimes Russia and France have complex relationships, the cooperation of scientists over the centuries-old history of contacts has practically not been interrupted. Today, the tendency to exchange research experience, help in scientific research continues. It can be seen when encountering a significant number of collections, catalogs, and articles of Russian-French authorship. At the same time, bilateral work on the introduction of archival materials, diplomatic documentation, the publication of memoirs, and the organization of joint exhibitions into the public domain allowed scientists to continue their research to restore the picture of the life of the French diaspora in St. Petersburg.
SPATIAL LAYOUT OF THE SOVIET UNION TIMBER PROCESSING COMPLEX: THE IDEA BEHIND THE FIRST FIVE-YEAR PLAN
Authors: ZYKIN Ivan V.
Published: October 2021

During the years of Soviet power, principal changes took place in the country’s wood industry, including in spatial layout development. Having the large-scale crisis in the industry in the late 1980s — 2000s and the positive changes in its functioning in recent years and the development of an industry strategy, it becomes relevant to analyze the experience of planning the spatial layout of the wood industry during the period of Stalin’s modernization, particularly during the first five-year plan. The aim of the article is to analyze the reason behind spatial layout of the Soviet wood industry during the implementation of the first five-year plan. The study is based on the modernization concept. In our research we conducted mapping of the wood industry by region as well as of planned construction of the industry facilities.
It was revealed that the discussion and development of an industrialization project by the Soviet Union party-state and planning agencies in the second half of the 1920s led to increased attention to the wood industry. The sector, which enterprises were concentrated mainly in the north-west, west and central regions of the country, was set the task of increasing the volume of harvesting, export of wood and production to meet the domestic needs and the export needs of wood resources and materials. Due to weak level of development of the wood industry, the scale of these tasks required restructuring of the branch, its inclusion to the centralized economic system, the direction of large capital investments to the development of new forest areas and the construction of enterprises.
It was concluded that according to the first five-year plan, the priority principles for the spatial development of the wood industry were the approach of production to forests and seaports, intrasectoral and intersectoral combining. The framework of the industry was meant to strengthen and expand by including forests to the economic turnover and building new enterprises in the European North and the Urals, where the main capital investments were sent, as well as in the Vyatka region, Transcaucasia, Siberia and the Far East.
SOCIOCULTURAL CREDO OF MODERN TRANSLATOR IN DIGITAL COMMUNICATION ENVIRONMENT
Authors: KUSHNINA Liudmila V. , Alikina Elena V.
Published: October 2021

The article is based on the idea that, in a digital communicative environment, there are changes in the structure of the human-translator activity and functions, some of which are transferred to the machine translation. The aim of the research is to find ways of translation and meta-translation activities integration in the cognitive translation space and speech space of the translation discourse. This requires the coordination of the translation discourse with existing digital platforms, development of new language technologies oriented towards a high-quality product that ensures successful interlingual, intercultural, and interpersonal interaction.
The methodological basis of the research is the concept of translation space which is based on a synergetic approach to translation involving harmonization of the source and target meanings, i.e., their adequacy and equivalence. The theoretical basis of the study is the notion of an epistemic situation as an extralinguistic basis of a text with ontological, methodological, and axiological components. The ontology of translation is represented by the idea of cognitivism, methodology — by synergy, axiology — by harmony. The result of the study is the correlation between the subject-centric and text-centric functions of a human-translator developing their reflexive, empathic, and other cognitive abilities which cannot be delegated to machine translation. There is transposition process of translator linguistic persona functions when the translator retains all subject-centric functions, whereas part of text-centric functions are performed by translation software. At this time, the social and cultural responsibility of the translator increases, since translation is assigned by a human and performed for a human.
PHENOMENOLOGICAL POETICS OF A LYRIC WORK: METHODOLOGICAL ASPECT
Authors: BARYKIN Alexey V.
Published: October 2021

The goal of this article is to present the methodological foundations of the phenomenological poetics of a literary work. The subject of the research is the principles of the phenomenological approach to poetological foundations, the object is the structural-semantic, textual-semiotic features of the lyric work.
The author summarizes the experience of different concepts of the phenomenological approach to revealing the essence of the receptive strategy of both artistic consciousness and research practice. The main attention is paid to the structure of artistic consciousness, the peculiarities of its intentional nature, reveals the specificity of various types of reduction, allowing to penetrate into the essence of artistic experience, its aesthetic reception.
The article puts forward the concept of a phenomenological interpretation of the structure of a poetic text at the syntagmatic and paradigmatic levels, a metaphysical understanding of the traditionally semiotic concepts of syntagmatics and paradigmatics, which formally set the landmarks of text boundaries in their horizontal and vertical deployment. Based on the ontological and phenomenological aspects of the consideration of artistic space, the text appears as a phenomenon that goes beyond the limits of its own sign definition, becoming an essential-valuable “determinant” and regulator of artistic and research intentions, implying different ways and levels of subjective expression in poetic discourse. In addition to the basic, phenomenological approach, the research methodology consists of the principles of “ontological poetics”, “receptive aesthetics”.
QSAR Studies to Predict Activity of HSP90 Inhibitors
Authors: Patil Vaishali M. , Masand Neeraj , Gupta Satya P. , Blagg Brian S. J.
Published: October 2021

Heat shock protein 90 (HSP90) is a multichaperone complex that mediates the maturation
and stability of a variety of oncogenic signaling proteins. HSP90 has emerged as a promising target
for the development of anticancer agents. Heterocyclic chemical moieties with HSP90 inhibitory
activity were studied continuously during the last decades, and resulting data were applied by medicinal
chemists to design and develop new drugs. Their structure-activity relationship (SAR) studies and
QSAR models have been derived to assist the current drug development process. The QSAR models
are obtained via multiple linear regression (MLR) and non-linear approaches. Interpretation of the
reported model highlights the core template required to design novel, potent HSP90 inhibitors to be
used as anticancer agents.
Recent Progress in the Synthesis of Heterocycles based on 1,3-diketones
Authors: Talbi Soumaya , Dib Mustapha , Bouissane Latifa , Abderrafia Hafid , Rabi Souad , Khouili Mostafa
Published: October 2021

:

N,O-heterocycles containing the dicarbonyl ring play a significant role in heterocyclic and
therapeutic chemistry. Since the discovery of 1,3-diketones, numerous research works have been
achieved regarding the synthesis and its chemical reactivity. In this review, we have described the most
relevant publications involving β-diketone compounds published during the period between 2018 to date.
In addition, we include the 1,3-diketones-based heterocyclic compounds prepared by various synthetic
methodologies.
Computational Design of a Novel Candidate Multi-Epitope Vaccine to Boost Immune Responses against SARS‐COV‐2
Authors: Mohammadi Shiva , Pour Soudabe Kavusi , Barazesh Mahdi , Bahrami Yadollah , Jalili Sajad
Published: October 2021

Background:

The fast development of an effective vaccine is the major demand for protection against the SARS-COV-2 virus outbreak. Immuno-informatics tools are time-saving and cost-effective methods to hasten the design and establishment of a proficient multi-peptide candidate vaccine. The utilization of multi-epitope-based vaccines has demonstrated to be a promising immunization approach against viruses due to the induction of long-term protective immunity.

Method:

In the present study, a complete computational approach was conducted to design a multi-epitope-based vaccine composed of cytotoxic T lymphocyte and helper T lymphocyte epitopes of Spike and Nucleocapsid proteins conserved regions. The potential viral peptides as the candidate vaccine were screened regarding convenient features like hydrophilicity, flexibility, antigenicity, and charged properties. In the next step, the vaccine efficacy needed to be improved by an immune adjuvant. For this purpose, the C-terminal domain of heat shock protein gp96 (CT-GP96) was applied as a potent adjuvant for enhancing immunity. The final assembled construct was fused with the assistance of suitable linkers and cloned in a pET28a expression vector for overproduction of the vaccine in a bacterial host.

Result:

Following validation of the final construct in terms of its efficacy, stability, and exposure ability, molecular docking analysis was carried out to reveal its interaction with toll-like receptor 4, which is required to trigger the immune response. The molecular simulations by iMODS software confirmed the stability of the binding interface. Additionally, the computational cloning of the assembled vaccine in pET28a plasmid showed the possibility of producing a vaccine construct post-transformation in an E. coli host.

Conclusion:

The computational analysis indicated that this construct could be a potent prophylactic and therapeutic multi-epitope vaccine candidate against SARS‐COV‐2 once its effectiveness is verified by experimental and animal studies.
US Policy towards the Maghreb: An Arduous Combination of Strategic Interests and Economic Stakes
Authors: Iratni Belkacem
Published: October 2021

The relations of the United States of America (USA) with the Maghreb States are ancient, though intermittent and not very substantial. Globally, the Maghreb does not constitute a vital region for US strategic concerns. It is included broadly in what the American policy makers depict as the Middle East and North Africa (MENA) configuration and thus does not represent a specific or a peculiar zone for American involvement or responsibility.However, the Maghreb presents a relative importance in the US designs whether in terms of strategic concerns or economic assets, particularly with the worldwide emergence of terrorism. This care remains only provisory.Strategic alignments (Morocco and Tunisia) and energy resources (Algeria and Libya) have relatively attracted US attention to the Maghreb, but security matters, linked to the widespread of terrorism, have strengthened the relations between the two parties, without, however, upgrading their partnership to the level of vitally crucial dynamics, interdependent needs, and promising prospects.
The US-backed Moroccan- Israeli Normalization Agreement: Implications on the Future of the Maghreb Union
Authors: Guemide Boutkhil , Amir Samir
Published: October 2021

After the signing of the Abraham Accords between the Zionist entity and the countries of the United Arab Emirates (UAE) and Bahrain under the auspices of US President Trump, Morocco joined the normalization process and became the latest country in the Arab League which agreed to normalize its relations with Israel through US mediation. As part of the agreement, the US agreed to recognize Morocco’s sovereignty over the disputed Western Sahara region, and to release $ 1 billion in military aid to Morocco. This Moroccan step added fuel to the flame and worsened its relations with the Palestinian Authority, on the one hand, and the countries of the Maghreb union, on the other hand. Morocco’s normalization of its relations with the Zionist entity does not only deteriorate its relations with Algeria, which supports the POLISARIO, but also affects the future of the Maghreb union. This paper discusses the implications of Morocco’s normalization of its relations with the Zionist entity on the Arab Maghreb integration project. It takes into account the Moroccan normalization process as a part of the overall Arab approach. In addition, it highlights the Israeli relations with the Maghreb countries of Morocco, Mauritania, and Tunisia, and how Moroccan normalization will affect the future of integration of Maghreb union.
Hubungan Faktor Sosiodemografi dengan Angka Kejadian Nyeri Kronik pada Pasien Pasca Operasi Bedah Mayor di Rumah Sakit Dr. Saiful Anwar Malang
Authors:   Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya Indonesia, Mailawati Trianna , Laksono Ristiawan Muji ,   Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya, Fatoni Arie Zainul ,   Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya
Published: October 2021

Latar belakang: Nyeri kronik pasca bedah mayor merupakan komplikasi bermakna pada sebagian besar pasien. Faktor sosiodemografi menjadi salah satu perhatian dalam prevalensi kejadian nyeri kronik pasca bedah mayor dan belum ada data mengenai angka kejadian nyeri kronik dan faktor yang mempengaruhinya di Indonesia, khususnya di Malang. Penelitian ini bertujuan untuk mengetahui hubungan faktor sosiodemografi seperti usia, jenis kelamin, pendidikan, dan tingkat pendapatan terhadap angka kejadian nyeri pasca bedah. Metode: Penelitian ini tergolong penelitian epidemiologi analitik dengan metode cross sectional pada 123 pasien yang menjalani operasi elektif bedah mayor di RS Dr. Saiful Anwar Malang periode Juli-Desember 2018. Penelitian dilaksanakan dengan metode wawancara pada responden. Variabel penelitian ini yaitu usia, jenis kelamin, tingkat pendidikan dan tingkat pendapatan. Data yang diperoleh dianalisa dengan menggunakan uji korelasi Spearman pada SPSS 25.0. Hasil: Sebanyak 66 subjek tidak mengalami nyeri kronik dan 57 subjek mengalami nyeri kronik pasca bedah mayor. Tingkat pendidikan memiliki hubungan yang signifikan dengan dengan angka kejadian nyeri kronik (p=0,038). Akan tetapi hubungan yang terjadi bersifat lemah (koefisien korelasi Spearman =0,187). Faktor sosiodemografi di antaranya usia, jenis kelamin dan pendapatan tidak berhubungan dengan angka kejadian nyeri kronik pasca bedah mayor (p>0,05). Kesimpulan: Faktor tingkat pendidikan memiliki hubungan yang bersifat lemah dengan angka kejadian nyeri kronik pasca operasi bedah mayor. Akan tetapi, faktor sosiodemografi seperti usia, jenis kelamin, dan pendapatan tidak berhubungan dengan angka kejadian nyeri kronik pasca operasi bedah mayor.
An mHealth App to Support Fertility Patients Navigating the World of Infertility (Infotility): Development and Usability Study
Authors: Kruglova Katya , O'Connell Siobhan Bernadette Laura , Dawadi Shrinkhala , Gelgoot Eden Noah , Miner Skye A , Robins Stephanie , Schinazi Joy , Zelkowitz Phyllis
Published: October 2021

Background

The experience of infertility and its treatment engenders considerable stress and is often described as an emotional rollercoaster. A mobile health (mHealth) app may be a novel solution to address the psychoeducational and psychosocial support needs of fertility patients because of its potential to reduce stress and increase patient empowerment. There are a few fertility-related apps that provide information and support to both men and women undergoing fertility treatment; however, none have documented their development and evaluation process.

Objective

This study aims to describe the development and evaluation process of a bilingual mHealth app, Infotility, designed to meet the psychoeducational and psychosocial support needs of men and women undergoing fertility treatment.

Methods

To develop the Infotility app, we adhered to the Medical Research Council guidelines for the development and evaluation of complex interventions. First, we conducted literature reviews and needs assessment surveys of fertility patients and health care providers who informed the content and design of the app. Second, we tested the intervention with a small group of end users who provided feedback on the design and appropriateness of the app’s content. Third, we evaluated the uptake and usability of the app using a pre-post study design. Finally, we updated the app’s content based on participants’ feedback and searched for partners to disseminate the app to the broader public.

Results

This study is the first to describe the development and evaluation process of an mHealth app for men and women undergoing fertility treatment. The app met its goal in providing fertility patients with a clinician-approved, portable resource for reliable information about medical and psychosocial aspects of infertility and its treatments and a confidential peer support forum monitored by trained peer supporters. Participants rated the engagement, functionality, information, and esthetics of the app positively, with an overall app quality mean score of 3.75 (SD 0.53) and a star rating of 3.43 (SD 0.75), with a total possible score and star rating of 5.00.

Conclusions

By documenting the systematic development and evaluation of the mHealth app for men and women undergoing fertility treatment, this paper can facilitate the replication of the study intervention and the development of similar mHealth apps.
Cytochrome P450 1B1 Overexpression in Cervical Cancers: Cross-sectional Study
Authors: Alshammari Fatemah O F O , Al-saraireh Yousef M , Youssef Ahmed M M , Al-Sarayra Yahya M , Alrawashdeh Hamzeh Mohammad
Published: October 2021

Background

Current standard treatments for patients with recurrent cervical cancer are not very effective and are associated with severe toxicity. Recently, the rational approach for the discovery of new therapies for cervical cancer is based on the alterations in the molecular biology of cancer cells. One of the emerging molecular changes in cancer cells is the aberrant expression of cytochrome P450 1B1 (CYP1B1). This unique enzyme has been reported to be selectively overexpressed in several cancers.

Objective

The aim of this study was to examine CYP1B1 expression in cervical cancers and to assess the enzyme’s relationship with several clinicopathological features.

Methods

Immunohistochemistry was performed to examine CYP1B1 expression in 100 patient samples with cervical cancer and 10 patient samples with normal healthy cervical tissues.

Results

CYP1B1 was expressed in the majority of the cervical cancer samples (91/100, 91.0%) but not in normal healthy cervical samples. The difference in the expression of CYP1B1 between healthy and tumorous cervical tissues was significant (P=.01). Moreover, the frequency of CYP1B1 expression was found to be significantly higher in patients with advanced grades of the disease (P=.03) and in patients having metastasis to the lymph nodes (P=.01). Surprisingly, there was a significantly higher expression of CYP1B1 in patients with a high prevalence of human papilloma virus 16/18 (P=.04).

Conclusions

The differential profile of CYP1B1 expression between cervical cancer tissues and normal cervical tissues suggests that CYP1B1 may be used as a target for future therapeutic exploitations.
Facebook Support Groups for Pediatric Rare Diseases: Cross-Sectional Study to Investigate Opportunities, Limitations, and Privacy Concerns
Authors: Titgemeyer Sarah Catrin , Schaaf Christian P
Published: October 2021

Background

Because of the nature of rare diseases with affected individuals being widely geographically dispersed, finding an in-person/offline support group itself can be a challenge. Affected individuals therefore turn to social networking platforms such as Facebook for online support groups.

Objective

We aim to put into perspective the opportunities Facebook offers as a tool for pediatric rare disease support groups by investigating its use, advantages, and limitations including privacy concerns. We analyze group accessibility and usage, advantages specific to rare diseases, perceived privacy, and views on using Facebook for communication between health professionals and parents, pharmaceutical companies, and study recruitment.

Methods

We contacted 12 Facebook support groups for 12 respective rare diseases with pediatric onset and invited group members to participate in a cross-sectional online survey.

Results

Of 231 respondents, 87.0% (n=201) of respondents were female, 12.6% (n=29) were male, and 0.4% reported another sex (n=1). Respondents’ mean age was 41.56 years (SD 9.375); 91.3% (n=211) of respondents were parents (183 mothers, 27 fathers, 1 other sex); 59.7% (n=138) reported a self-initiated search for the Facebook group, 24.2% (n=56) received recommendations from their health professionals, and 12.6% (n=29) recommendations from someone else affected by the disease. On average, support group members visited Facebook at least once a day, visited and passively participated (read/liked posts) several times a week, and participated actively (commented/posted) once a month. As much as 79.2% (183/231) agreed that they would like to have health professionals as members of the respective Facebook group. Group members expressed more concern about privacy issues on Facebook in general than in their respective Facebook support groups, with concerns mostly related to Facebook itself and nongroup members.

Conclusions

Our study confirmed that Facebook enhances support group accessibility for parents of children with rare diseases. Group participants perceive a reduction and elimination of distance, a common challenge in rare disease, and Facebook support groups create an environment of perceived privacy. The group’s privacy setting can be a critical factor for active support group participation. Sharing personal information and pictures on Facebook is very common among group participants, which shows the importance of discussing and protecting children’s privacy rights in this context.

Trial Registration

German Clinical Trials Register DRKS00016067; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00016067
Theoretical Study of Oxygen Atom Adsorption on A Polycyclic Aromatic Hydrocarbon Using Density-Functional Theory
Authors: Pradipta Mokhammad Fajar , Pranowo Harno Dwi , Alfiyah Viny , Hutama Aulia Sukma
Published: October 2021

Potential energy curves (PECs) and energy profiles of atomic O attack on coronene as a model for graphene/graphitic surface and interstellar reaction surface have been computed at the unrestricted B3LYP/cc-pVDZ level of theory to elaborate on atomic O attack mechanism and chemisorption on coronene. The PECs were generated by scanning the O atom distance to the closest carbon atom on "top" and "bridge" positions in the coronene, while fully relaxed geometries in the triplet state were investigated to gain the energy profile. We found that the most favorable geometry as the final product was the chemically bound O on the "bridge" site in the singlet state with an interaction energy of –29.2 kcal/mol. We recommended a plausible mechanism of atomic O attack and chemisorption reaction on coronene or generally graphitic surface starting from the non-interacting O atom and coronene systems into the chemically bound O atom on coronene.
Phenolics Profiling and Free Radical Scavenging Activity of Annona muricata, Gynura procumbens, and Typhonium flagelliforme Leaves Extract
Authors: Septaningsih Dewi Anggraini , Yunita Amalia , Putra Cecep Abdurohman , Suparto Irma Herawati , Achmadi Suminar Setiati , Heryanto Rudi , Rafi Mohamad
Published: October 2021

The leaves of Annona muricata (sirsak), Gynura procumbens (sambung nyawa), and Typhonium flagelliforme (keladi tikus) have been used as traditional medicines in Indonesia. This study aims to determine the antioxidant capacity and putatively identified phenolics from the leaves of three medicinal plants forementioned above. We used the DPPH (2,2-diphenyl-1-picrylhydrazyl) method for measuring radical scavenging (antioxidant assay) while the phenolics profiling was determined using UHPLC-Q-Orbitrap HRMS. The results showed that the percentage of radical scavenging activity of G. procumbens leaves extract in ethanol was higher than the other two plants. Phenolics profiling of the three medicinal plants was identified with 38 compounds belonging to flavones and flavanols hydroxycinnamic acid, and several other groups. The number of metabolites identified putatively was 12, 31, and 19 metabolites in the extracts of A. muricata, G. procumbens, and T. flagelliforme, respectively. The results confirmed the correlation between the phenolics presence and the antioxidant capacity of three plants used in this study.
Azo Dye Adsorption onto Cobalt Oxide: Isotherm, Kinetics, and Error Analysis Studies
Authors: Hami Hawraa Kassem , Abbas Ruba Fahmi , Azeez Shireen Abdulmohsin , Mahdi Nedaa Ibrahim
Published: October 2021

The current study focused on utilizing cobalt oxide to eliminate hazardous Eriochrome Black T (EBT) dye. The impact of pH (2, 4, 7, 8, and 10) and temperature (45, 50, and 55 °C) was examined for EBT removal. The results show that the maximum sorption occurred at pH = 2 and that the removal percentage increased with increasing temperature. Five non-linear regression methods were used to predict the best isotherm and kinetic models. A coefficient of non-determination, K2, was very helpful for selecting the RMSD function as a preferable error function among the five methods. Isothermal models to illustrate equilibrium sorption information, the Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich models were used. The results showed that the Langmuir model (R2 = 0.99) was the most favorable, indicating monolayer sorption of EBT occurred. The kinetics models were analyzed using pseudo-first-order and pseudo-second-order whereas the sorption information was well described by the pseudo-second-order model (R2 = 0.99). The results of the thermodynamic study appeared that the adsorption of EBT was endothermic, feasible, spontaneous, and physical adsorption.
λ-MnO2 Thin Films with Sponge-Like Structures: Synthesis, Characterization and Physiochemical Applications
Authors: Ahmed Khalid Abdelazez Mohamed
Published: October 2021

Manganese dioxide has acquired significant research attentiveness in many fields over the past years because of its exciting physicochemical features. The magnetized λ-MnO2 thin films with sponge-like structures (TSLs) were prepared by hydrothermal-soft chemical and delithiation-lithium manganese process. The XRD, XPS, EDX, FESEM, TEM, HR-TEM, and N2 adsorption-desorption techniques were used to characterize the as-prepared product’s structure composition, morphology, and surface area. The particle growth details of λ-MnO2 are postulated by the oxidation-ionic change-delithiation (OID) mechanism. The electrochemical property was analyzed by galvanostatic discharge-charging, electrochemical impedance spectrum (EIS), and cyclic voltammetry (CV). Special attention of λ-MnO2 S.L.s is given to their applications in the degradation of methyl orange (MO) from wastewater under O2 air bubble pump and cathodic substance in the lithium-ion battery. Due to the peculiarity crystal form and morphology face, the λ-MnO2 TSLs might be promisingly applied in the various physicochemical area.
Difluoroboron Curcumin Complex: A Study on Determination of Acidity Constants and Quantitative Analysis of Arsenic(III)
Authors: Thang Nguyen Quoc , An Tran Nguyen Minh , Tran Le Thi Thanh , Nhan Do Tam , Tan Mai Ngoc , Tan Le Van
Published: October 2021

In this study, the complex of difluoroboron, curcumin (BF2-Cur), has been synthesized and characterized via the combination of Boron trifluoride-diethyl etherate ((C2H5)2OBF3) and curcumin. However, the new dissociation constants, pKa1 and pKa2 of the BF2-Cur complex, have been indicted by the values of 8.44 ± 0.16 and 9.76 ± 0.13, respectively. On the other hand, the reagent was also used to determine As(III) in aqueous solutions by UV–Vis spectrophotometry. As a result, the method was validated for accuracy, precision, linearity, and sensitivity, and the linear range was from 1.0 to 25.0 µmol/L, with the linear regression, A = 0.0027 C + 0.0106, correlation coefficient R2 = 0.9969. Besides, the limit of detection (LOD) and limit of quantification (LOQ) were determined as 0.83 and 2.10 µmol/L, respectively. Thus, the developed method is successfully used for quantitative analysis of total arsenic in wastewater by reducing As(V) to As(III), then determining As(III) with high accuracy results.
“Am I Man Enough?”: Diskriminasi terhadap Identitas Transpria Muda (Studi Analisis Video YouTube Trans Men Talk Indonesia)
Authors: Rahmawati Himas Nur
Published: October 2021

Discourse contestation around youth in Indonesia still rarely touches issues related to gender minority identities, transman (transgender man) is one of them. This research discusses the complexity of the problems and situations of discrimination experienced by young transmen in Indonesia. The research was conducted by analyzing the YouTube video of Trans Men Talk Indonesia entitled "Transmen Indonesia: We are Exist, Real and Deserved to be Happy too. Part 1. " This community, which was founded by young transmen, has dialogued YouTube as an arena for self-articulation and a performative space to show their agency. This study uses a qualitative content analysis method by selecting thematic narratives and visual texts. The findings that resulted are young transmen experiencing a discrimination which can be described through three domains, namely in (1) dating life; (2) occupation, as well as; (3) scarcity of safe space. Collective solidarity for the transmen community is an urgency. This effort is made in order to create an inclusive space that is commensurate with those who are often carried out by the power of cisnormativity.
Musik bukan Pekerjaan: Distingsi dan Transgresi dalam Karier Bermusik Musisi Metal Ekstrem Yogyakarta
Authors: Lukisworo Agustinus Aryo , Sutopo Oki Rahadianto
Published: October 2021

This article focuses on the separation between music and work that has been done by Yogyakarta’ extreme metal musician. Along with a deeper explanation of youth cultural practices in Yogyakarta, this article also provides a gap bridge between youth culture and youth transition perspective. In order to obtain those purposes, this article utilizes youth culture perspective and youth transition perspective approach, together with field and doxa. Regarding the research method, this article uses qualitative ethnographic approach and has been done through six months data collecting. This research approach was chosen in order to capture the concrete reality that has been experienced by research informants. Based on the findings analysis, which has been done both textually and interpretively, the separation between music and work among informants, on the one hand could be understood as a strategy to maintain informants' pride within the extreme metal scene. On the other hand, this separation also could be defined as a strategy to maintain informants' social position, especially as Indonesian middle class.
‘I’m Talking But No One Is Listening’
Authors: Gray Claire
Published: October 2021

Even though Prime Minister Margaret Thatcher’s term ended in 1990, the reverberations of her policies have lingered on in British politics, culture and social life. This paper discusses the legacy of Thatcher within the soundscapes present in the 2016 social realist film I, Daniel Blake (dir. Ken Loach). By looking at the effects of Thatcher’s policies and how they are made audible in working class communities, this paper ultimately questions whether her presence has truly disappeared. In employing the fields of hauntology and sound studies as an approach to Thatcherism, this study sonifies the voices of the past, and questions how they will echo in the future.
Editorial
Authors: Morton Melissa , Stein Ashley
Published: October 2021

Editorial for Issue 2.
Creating Space Where Music can Happen
Authors: Holub Mark
Published: October 2021

This article examines the role of pre-composed musical material as the basis of a band’s output, from the perspective of composer-bandleaders who direct ensembles of improvising musicians. The article proposes five distinct methods by which composer-bandleaders can navigate the ‘space’ of their band’s output and musical direction. The categories are described originally as follows: Setting a Mood, Call to Arms, Bookend, Elements in Free, Composition as Destination.  These proposed methods -— or approaches -— are discovered through the analysis of existing recorded materials and reflection on practice.
Proposal for a Dance Performance
Authors: Panagiotou Ioannis
Published: October 2021

Proposal for a Dance Performance is an artwork for music ensemble and PowerPoint. This work aims to transform -through the use of self-referential narration- dance notation, emails, program notes and technical rides, into performing instances. The paper puts the above artwork in a dialogue with works by Hanns Eisler, Alfred Johannes and Johannes Kreidler, which use music notation as a conceptual visual tool. Furthermore, this paper discusses the role of music as a character in a play, a technique found in Samuel Becket’s work. This combination of narration and notation is being proposed as a transdisciplinary methodology for breaking fixed notions of artistic practice.
INTENTIONAL HUMAN-CAUSED MORTALITY OF Plestiodon copei (SCINCIDAE)
Authors: Sánchez Sánchez Hermilo , Alvarado-Avilés Juan Carlos , Manjarrez Javier
Published: October 2021

Ninguno
PREDATION ON Scinax fuscovarius (ANURA, HYLIDAE) BY Scolopendra sp. (CHILOPODA: SCHOLOPENDRIDAE) IN THE STATE OF TOCANTINS, CENTRAL BRAZIL
Authors: Silva Elvis Almeida Pereira
Published: October 2021

Some arthropods groups produce substantial mortality in some vertebrate populations and have complex ecological interspecific interactions with vertebrates. Amphibians are preyed by invertebrates at all life stages, however no invertebrate species is recognized as specialist predator of this group. This short communication reports the predation of anuran by a centipede.
Análisis técnico de tres adhesivos comerciales para la industria de muebles
Authors: Sedano Mendoza Miriam , Ávila Calderón Luz Elena Alfonsina , Jardón Madrigal Guillermo
Published: October 2021

El objetivo del presente trabajo fue determinar la resistencia mecánica de tres adhesivos comerciales (marca COMEX, marca RESISTOL 850 y marca RESISTOL 950) de uso común en las industrias de muebles tradicionales ubicadas en la región oriente del estado de Michoacán. Se formuló el modelo experimental que se ajustara lo más posible a lo que realizaban en la mayoría de las empresas visitadas. El ensayo de resistencia mecánica se realizó de acuerdo a la norma ASTM D-5751 y bajo esta, se midiendo tres tiempos de prensado (acorde a la referencia que manejan en las empresas de muebles). Las propiedades fisicoquímicas de los adhesivos comerciales fueron determinadas: el contenido de sólidos, la viscosidad, el pH y la densidad. Con base en los resultados de la resistencia mecánica y las propiedades fisicoquímicas del adhesivo, se esclareció la correlación que existe entre ambos. Los resultados mostraron que, para los tres tiempos de prensado, los valores más altos de resistencia mecánica los presentó el adhesivo marca Resistol 850 y los valores más bajos fueron del adhesivo marca Comex. Con un 95% de confiabilidad (P>0.05), se encontró que, las varianzas de las poblaciones de la resistencia mecánica en las tres marcas de adhesivo, son diferentes en al menos un valor para los tiempos de prensado de 6 y 8 horas. Los resultados de las pruebas fisicoquímicas (pH, densidad y sólidos) mostraron que solo el adhesivo Resistol 850 se encontraba dentro de los rangos reportados por la marca, mientras que los valores de la viscosidad en las tres marcas de adhesivos estaban dentro de los rangos reportados. Para los tres adhesivos estudiados, se encontró que existe una correlación de 0.9695 entre el contenido de sólidos y la resistencia mecánica.
Continuing Professional Development (CPD) for Library Professionals in Academics Libraries of Ahmedabad/Gandhinagar
Authors: Solanki Mrugesh R.
Published: October 2021

Abstract: The main objective of this paper is to find out the training and development of LIS Professionals of and various aspects of Continuous Professional Development (CPD). Most of library professionals are satisfied with the standards of training meet the standards and they prefer on job training. Overall, the training and development activities improve job performance and it will enhance the technical skills and knowledge. They all recommend the training should be of week duration. Keyword: Training and Development, Continuous Professional Development (CPD), Staff development, HRD
Oral budesonide is an effective alternative to prednisone for treatment of autoimmune hepatitis
Authors: Anilovich Natanie J.
Published: October 2021

A clinical decision report using:

Manns MP, Woynarowski M, Kreisel W, et al. Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. Gastroenterology. 2010;139(4):1198-1206. https://doi.org/10.1053/j.gastro.2010.06.046

for a patient with autoimmune hepatitis developing septic arthritis secondary to prednisone therapy.
Metformin monotherapy is an effective alternative for management of gestational diabetes mellitus in patients refusing insulin monotherapy
Authors: Russeth Tyler
Published: October 2021

A clinical decision report using:

Ghomian N, Vahed SHM, Firouz S, Yaghoubi MA, Mohebbi M, Sahebkar A. The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial. J Cell Physiol. 2019;234(4):4695-4701. https://doi.org/10.1002/jcp.27238

for a patient with gestational diabetes mellitus (GDM) who does not wish to undergo insulin monotherapy.
Does HIV status confer a higher risk of acquiring COVID-19? Using Clinical Decision Science to combat patients’ anxiety
Authors: Guzman Camilo
Published: October 2021

A clinical decision report using:

del Amo J, Polo R, Moreno S, et al. Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy. Annals of Internal Medicine. 2020;173(7):536-541. https://doi.org/10.7326/m20-3689

for a patient with HIV and concerns about COVID-19 for immunocompromised individuals.
Peritoneal dialysis vs. hemodialysis: The choice of modality of dialysis may drastically affect the quality of life of patients initiating dialysis
Authors: Daryani Deepa
Published: October 2021

A clinical decision report using

Jung HY, Jeon Y, Park Y, et al. Better Quality of Life of Peritoneal Dialysis compared to Hemodialysis over a Two-year Period after Dialysis Initiation. Sci Rep. Jul 16 2019;9(1):10266. https://doi.org/10.1038/s41598-019-46744-1

for a young patient initiating dialysis.