bluuebunny/crossref_metadata_2025 huggingface dataset:
Lebanon’s October 2019 Revolution
Authors: Khater Lea Bou
Published: February 2021

In a world dominated by neoliberalism, there is renewed attention to labor organizing and radical forms of action outside the institutional framework. In Lebanon, the October 2019 Revolution brought to the forefront the capacity of labor to recompose its power in the face of the long-standing capitalist effort to decompose it. This essay first examines the outbreak of social unrest in 2019 that accompanied the failure of neoliberal policies. Second, it explains the absence and silence of the labor movement amid the 2019 revolution by state interference and at the service of a long-standing laissez-faire economy. Finally, it concludes by examining recent attempts of professionals to organize from within the October Revolution and the challenges they currently grapple with.
Thinking with Trans Now
Authors: Aizura Aren Z. , Bey Marquis , Beauchamp Toby , Ellison Treva , Gill-Peterson Jules , Steinbock Eliza
Published: February 2021

This roundtable considers trans theory’s status as a site of thinking racialization, empire, political economy, and materiality in the current historical, institutional, and political moment. We ask, what does it mean to think trans in a time of crisis?, and what is the place of critique in a crisis?, acknowledging that global crises are not insulated from trans, and trans is not insulated from the world. This roundtable looks to materialist formations to think trans now, including a new materialism premised on thinking about trans embodiment outside of trans as subject position, the materialism of objects and commodities, and a historical materialism shaped by queer of color critique.
Vacuolar protein Tag1 and Atg1–Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae
Authors: Kira Shintaro , Noguchi Masafumi , Araki Yasuhiro , Oikawa Yu , Yoshimori Tamotsu , Miyahara Aiko , Noda Takeshi
Published: February 2021

Under starvation conditions, cells degrade their own components via autophagy in order to provide sufficient nutrients to ensure their survival. However, even if starvation persists, the cell is not completely degraded through autophagy, implying the existence of some kind of termination mechanism. In the yeast Saccharomyces cerevisiae, autophagy is terminated after 10–12 h of nitrogen starvation. In this study, we found that termination is mediated by re-phosphorylation of Atg13 by the Atg1 protein kinase, which is also affected by PP2C phosphatases, and the eventual dispersion of the pre-autophagosomal structure, also known as the phagophore assembly site (PAS). In a genetic screen, we identified an uncharacterized vacuolar membrane protein, Tag1, as a factor responsible for the termination of autophagy. Re-phosphorylation of Atg13 and eventual PAS dispersal were defective in the Δtag1 mutant. The vacuolar luminal domain of Tag1 and autophagic progression are important for the behaviors of Tag1. Together, our findings reveal the mechanism and factors responsible for termination of autophagy in yeast.
Maternal provisioning and fluctuating thermal regimes enhance immune response in a reptile with temperature-dependent sex determination
Authors: Leivesley Jessica Alice , Rollinson Njal
Published: February 2021

The Charnov–Bull model of differential fitness is often used to explain the evolution and maintenance of temperature-dependent sex determination (TSD). Most tests of the model focus on morphological proxies of fitness, such as size traits, whereas early life physiological traits that are closely related to lifetime fitness might provide a framework for generalizing the Charnov–Bull model across taxa. One such trait is the strength of the early-life immune response, which is strongly linked to early-life survival and fitness. Here, we manipulated temperature, variance in temperature, and sex to test the Charnov–Bull model using a physiological trait, immune system strength, in the snapping turtle (Chelydra serpentina). We found no evidence of sex-specific differences in bactericidal capacity of hatchling blood, and no evidence that mean temperature influences bactericidal capacity. However, we did find that fluctuating incubation temperature (i.e. a more naturalized incubation regime) is associated with a greater bactericidal capacity compared with constant temperature incubation. We also found that egg mass, a proxy for maternal provisioning, is positively associated with bactericidal capacity. Our findings suggest that the evolution of temperature-dependent sex determination in reptiles is unrelated to our measure of early-life innate immunity. Our study also underlines how immune response is condition dependent in early life, and questions the biological relevance of constant temperature incubation in experimental studies on ectotherm development.
Attack behaviour in naive gyrfalcons is modelled by the same guidance law as in peregrine falcons, but at a lower guidance gain
Authors: Brighton Caroline H. , Chapman Katherine E. , Fox Nicholas C. , Taylor Graham K.
Published: February 2021

The aerial hunting behaviours of birds are strongly influenced by flight morphology and ecology, but little is known of how this relates to the behavioural algorithms guiding flight. Here, we used GPS loggers to record the attack trajectories of captive-bred gyrfalcons (Falco rusticolus) during their maiden flights against robotic aerial targets, which we compared with existing flight data from peregrine falcons (Falco peregrinus). The attack trajectories of both species were well modelled by a proportional navigation (PN) guidance law, which commands turning in proportion to the angular rate of the line-of-sight to target, at a guidance gain N. However, naive gyrfalcons operate at significantly lower values of N than peregrine falcons, producing slower turning and a longer path to intercept. Gyrfalcons are less manoeuvrable than peregrine falcons, but physical constraint is insufficient to explain the lower values of N we found, which may reflect either the inexperience of the individual birds or ecological adaptation at the species level. For example, low values of N promote the tail-chasing behaviour that is typical of wild gyrfalcons and which apparently serves to tire their prey in a prolonged high-speed pursuit. Likewise, during close pursuit of typical fast evasive prey, PN will be less prone to being thrown off by erratic target manoeuvres at low guidance gain. The fact that low-gain PN successfully models the maiden attack flights of gyrfalcons suggests that this behavioural algorithm is embedded in a guidance pathway ancestral to the clade containing gyrfalcons and peregrine falcons, though perhaps with much deeper evolutionary origins.
The Elusive Employment Effect of the Minimum Wage
Authors: Manning Alan
Published: February 2021

It is hard to find a negative effect on the employment effect of rises in the minimum wage: the elusive employment effect. It is much easier to find an impact on wages. This paper argues the elusive employment effect is unlikely to be solved by better data, methodology, or specification. The reasons for the elusive employment effect are the factors contributing to why the link between higher minimum wages and higher labor costs are weaker than one might think and because imperfect competition is pervasive in the labor market.
The North Samoyedic interrogative verb meaning ‘say what’
Authors: Mus Nikolett
Published: February 2021

A cross-linguistically rare interrogative category (i.e., an interrogative verb with the meaning ‘say what’) is observed in the North Samoyedic (Uralic) languages. The interrogative verb in these languages is used in content questions, and functions as the predicate of the main or the embedded clause. It takes the regular verb morphemes with two exceptions: it (i) does not display object agreement, and (ii) cannot combine with the regular past tense morpheme. Furthermore, there is also an ordering restriction on multiple questions containing the interrogative verb. The morphosyntactic evidence suggests that the North Samoyedic interrogative verb is analyzed as a result of a wh-object incorporation.

Kokkuvõte. Nikolett Mus: Põhjasamojeedi keelte küsiverb tähendusega ‘mida ütlema’. Põhjasamojeedi (uurali) keeltes esineb keeleüleselt haruldane küsiv kategooria (st küsiverb tähendusega ’mis asja’). Nendes keeltes kasutatakse küsiverbi sisuküsimustes ja küsiverb toimib pea- või kõrvallauses predikaadina, liitudes tavaliste verbimorfeemidega, välja arvatud kahel juhul: küsiverb (i) ei väljenda objektiühildumist, ja (ii) ei kombineeru lihtmineviku morfeemiga. Lisaks on küsiverbil teatavad järjestuspiirangud küsiverbi sisaldava kompleksküsimuse korral. Morfosüntaktilised andmed viitavad, et põhjasamojeedi küsiverb on analüüsitav kui küsisõnalise objekti inkorporatsiooni tulemus.

Аннотация. Николетт Муш: Северосамодийский вопросительный глагол ‘что сказать’. В северосамодийских языках (уральская языковая семья) есть типологически редкий вопросительный глагол со значением ‘что сказать’. Этот глагол используется в частных вопросах в качестве предиката главного или подчиненного предложения. Он принимает обычные словоизменительные суффиксы за двумя исключениями: он не сочетается (i) с объектным спряжением и (ii) с показателем прошедшего времени индикатива. Кроме того, существуют ограничения на относительный порядок вопросов с вопросительным глаголом. Данные морфосинтаксиса свидетельствуют о том, что северносамодийский вопросительный глагол возник в результате инкорпорации объекта — вопросительного местоимениия.
RHEUMATIC DISEASES AND PREGNANCY (LITERATURE REVIEW)
Authors: Bondareva T.
Published: February 2021

. The problem of pregnancy in rheumatic diseases does not lose its relevance. The most studied is the course of pregnancy in patients with rheumatoid arthritis, systemic lupus erythematosus and axial spondyloarthritis. Observations in other systemic connective tissue diseases are episodic and do not allow us to draw reliable conclusions. The course of the disease itself, as well as the therapy received by patients, can affect pregnancy, starting with the possibility of conception and ending with unfavorable pregnancy outcomes for the mother and fetus. The onset of pregnancy should be planned at the time of remission or minimal activity of the disease. Of particular interest is drug therapy in patients with rheumatic diseases during gestation. This issue has been and remains complex and has not been fully studied due to the fact that any conclusions about the effect of drugs on the fetus are made retrospectively and cannot be the result of a deliberately initiated study. Currently allowed, though with some reservations, during pregnancy drugs are glucocorticoids, non-steroidal anti-inflammatory drugs, hydroxychloroquine and sulfasalazine. The development of genetic engineering has raised the question of the possibility of using genetic engineering basic therapy during gestation. Currently, the largest number of observations is available for TNF-α inhibitors, the use of which is recognized as possible during pregnancy. The presence of rheumatic disease in itself is not an absolute indication for a caesarean section. The question of the method of delivery is decided individually. Pregnant patients with rheumatic diseases should be under regular joint supervision of an obstetrician-gynecologist, rheumatologist and neonatologist
A Supply Chain Theory of Factoring and Reverse Factoring
Authors: Kouvelis Panos , Xu Fasheng
Published: February 2021

Factoring is a financial arrangement where the supplier sells accounts receivable to the factor against a premium and receives cash for immediate working capital needs. Reverse factoring takes advantage of the retailer’s payment guarantee and the credit rating differential between a small supplier and a large retailer, enabling the supplier to receive financing at a more favorable rate. We develop a supply chain theory of (recourse/non-recourse) factoring and reverse factoring showing when these post-shipment financing schemes should be adopted and who really benefits from the adoption. We find that recourse factoring is preferred when the supplier’s credit rating is relatively high, whereas non-recourse factoring is preferred within certain medium range of ratings. Both factoring schemes, if adopted, benefit both the supplier and the retailer, and thus the overall supply chain. Further, we find that reverse factoring may not always be preferred by suppliers compared to recourse and non-recourse factorings. Retailers should only offer reverse factoring to suppliers with low (but above a threshold) to medium credit ratings. The optimally designed reverse factoring program can always increase the retailer’s profit, but it may leave the supplier indifferent to the current factoring option when followed by an aggressive payment extension. More importantly, contrary to conventional wisdom, our theory implies that reverse factoring could be adopted even when the retailer has no credit rating advantage over the supplier, and it could benefit the retailer even without extending payment terms.

This paper was accepted by Victor Martínez-de-Albéniz, operations management.
Sensitivity Analysis for the Stationary Distribution of Reflected Brownian Motion in a Convex Polyhedral Cone
Authors: Lipshutz David , Ramanan Kavita
Published: February 2021

Reflected Brownian motion (RBM) in a convex polyhedral cone arises in a variety of applications ranging from the theory of stochastic networks to mathematical finance, and under general stability conditions, it has a unique stationary distribution. In such applications, to implement a stochastic optimization algorithm or quantify robustness of a model, it is useful to characterize the dependence of stationary performance measures on model parameters. In this paper, we characterize parametric sensitivities of the stationary distribution of an RBM in a simple convex polyhedral cone, that is, sensitivities to perturbations of the parameters that define the RBM—namely the covariance matrix, drift vector, and directions of reflection along the boundary of the polyhedral cone. In order to characterize these sensitivities, we study the long-time behavior of the joint process consisting of an RBM along with its so-called derivative process, which characterizes pathwise derivatives of RBMs on finite time intervals. We show that the joint process is positive recurrent and has a unique stationary distribution and that parametric sensitivities of the stationary distribution of an RBM can be expressed in terms of the stationary distribution of the joint process. This can be thought of as establishing an interchange of the differential operator and the limit in time. The analysis of ergodicity of the joint process is significantly more complicated than that of the RBM because of its degeneracy and the fact that the derivative process exhibits jumps that are modulated by the RBM. The proofs of our results rely on path properties of coupled RBMs and contraction properties related to the geometry of the polyhedral cone and directions of reflection along the boundary. Our results are potentially useful for developing efficient numerical algorithms for computing sensitivities of functionals of stationary RBMs.
On Uniform Exponential Ergodicity of Markovian Multiclass Many-Server Queues in the Halfin–Whitt Regime
Authors: Arapostathis Ari , Hmedi Hassan , Pang Guodong
Published: February 2021

We study ergodic properties of Markovian multiclass many-server queues that are uniform over scheduling policies and the size of the system. The system is heavily loaded in the Halfin–Whitt regime, and the scheduling policies are work conserving and preemptive. We provide a unified approach via a Lyapunov function method that establishes Foster–Lyapunov equations for both the limiting diffusion and the prelimit diffusion-scaled queuing processes simultaneously. We first study the limiting controlled diffusion and show that if the spare capacity (safety staffing) parameter is positive, the diffusion is exponentially ergodic uniformly over all stationary Markov controls, and the invariant probability measures have uniform exponential tails. This result is sharp because when there is no abandonment and the spare capacity parameter is negative, the controlled diffusion is transient under any Markov control. In addition, we show that if all the abandonment rates are positive, the invariant probability measures have sub-Gaussian tails regardless whether the spare capacity parameter is positive or negative. Using these results, we proceed to establish the corresponding ergodic properties for the diffusion-scaled queuing processes. In addition to providing a simpler proof of previous results in Gamarnik and Stolyar [Gamarnik D, Stolyar AL (2012) Multiclass multiserver queueing system in the Halfin-Whitt heavy traffic regime: asymptotics of the stationary distribution. Queueing Systems 71(1–2):25–51], we extend these results to multiclass models with renewal arrival processes, albeit under the assumption that the mean residual life functions are bounded. For the Markovian model with Poisson arrivals, we obtain stronger results and show that the convergence to the stationary distribution is at an exponential rate uniformly over all work-conserving stationary Markov scheduling policies.
Programmable Logic Controller (PLC) Based Paint Viscosity Control System
Authors: Wicaksono Gema Ridho , Puriyanto Riky Dwi
Published: February 2021

Automatic control has been developed in various fields, one of which is paint quality control. Paint quality can be controlled from various categories, including paint quality based on its viscosity. Therefore, we need a system that can control the viscosity of the paint. The paint viscosity control system uses the PLC OMRON CP1E-NA20DRA with a heater as a heat source, and the LM35DZ sensor as a temperature reading sensor, and the RPM reading is used to calculate the viscosity value. The programming language used is the ladder diagram on the CX-Programmer. This system uses the PID (Proportional, Integral, and Derivative) Algorithm so that temperature control can be set at 30ºC so as not to affect the viscosity of the paint. In addition, this prototype provides two PID tuning options, namely manual and auto-tuning. Researchers get the results that a good temperature control system response has a PB value = 0.2%; Ti = 452.5s and TD = 66.6s. and control the accuracy level of paint viscosity control of 67.82%.
Leachate and Irrigation Sensor Development and Performance in Container Nursery Production
Authors: Cypher Quinn , Fulcher Amy , Wright Wesley C. , Sun Xiaocun , Fessler Lauren
Published: February 2021

Highlights

Using leaching fraction to schedule irrigation is recommended yet no automated measurement system exists.

Sensors were developed to automatically measure leachate and irrigation within a sensor network.

There was no difference between sensor measured and manually captured volume for sensors deployed in a nursery.

After deployment in commercial nurseries, sensors accurately measured leachate and irrigation within 10% margin.

Abstract. Nursery crops are often over-irrigated, resulting in wasted water and agrochemical inputs. Irrigating based on leaching fraction is recommended, yet an automated system for measuring and recording nursery container effluent (leachate) does not exist. The objective of this research was to develop and test a sensor-based system for real-time leachate and irrigation measurement in outdoor commercial nurseries. Sensors were developed to automatically measure irrigation and leachate volume in container nurseries that use overhead irrigation with the goal of facilitating the development of an automated leaching fraction-based irrigation system. Sensors were built using readily available components, including tipping bucket mechanisms calibrated to either 4.7 or 8.2 mL per tip, and were designed and constructed to function with commonly used 3.8-, 11.4-, and 14.5-L nursery containers. Sensor networks were developed in order to collect data from the sensors. Sensors were deployed at three commercial nurseries and tested using closed- and open-loop tests. Initially, a closed-loop test was performed on a subset of the sensors to test the integrity of the sensor-container system when subjected to an overhead irrigation delivery system. Following closed-loop tests, sensors were subjected to tests utilizing directed applications of water to compare sensor measurements with the volume of water applied and to compare sensor measurements over time (pre- and post-season). There was no difference between leachate measured by sensors and leachate captured and measured manually in closed-loop tests (p = 0.0570). In directed applications, sensors measured water flow with less than 3% margin at the beginning of the season (p = 0.0485) and less than 10% margin at the end of the season (p = 0.0390) regardless of container size. Pre- and post-season comparisons showed equivalence at the 10% margin for the 4.7-mL tipping bucket size (p = 0.0043) and at 5% for those calibrated to 8.2 mL per tip (p = 0.0198). Sensors deployed in commercial nurseries accurately measured leachate and irrigation within a 10% margin in real-time, on an individual plant scale, making them a viable option for a leaching fraction-based irrigation schedule. Keywords: Container effluent, Container-grown plants, Leaching fraction, Irrigation schedule, Sensor network.
Polarized spectroscopic properties of disordered Er3+:Gd2SrAl2O7 crystal
Authors: Deng Baicheng , Gong Xinhong , Chen Yujin , Huang Jianhua , Lin Yanfu , Luo Zundu , Huang Yidong
Published: February 2021

A multi-position disordered Er3+:Gd2SrAl2O7 single crystal was grown by the Czochralski method. Room temperature polarized spectral properties of the crystal were investigated in detail. The Judd–Ofelt theory was applied to analyze the polarized absorption spectra. The peak stimulated emission cross-sections of the 4I13/2→4I15/2 transition reach 0.79 ×10−20 and 1.25×10−20 cm2 for σ and π polarizations, respectively. The gain curves are flat with full widths at half the maximum larger than 60 nm. Fluorescence lifetimes of the 4I13/2 multiplet for Er3+ ions were fitted to be 4.93 ms and 3.48 ms from measured fluorescence decay curves for bulk and powder samples, respectively. The results show that the Er3+:Gd2SrAl2O7 crystal may be a potential gain medium for a 1.55 µm laser with low pumping threshold.
Sensing in the presence of strong noise by deep learning of dynamic multimode fiber interference
Authors: Nguyen Linh V. , Nguyen Cuong C. , Carneiro Gustavo , Ebendorff-Heidepriem Heike , Warren-Smith Stephen C.
Published: February 2021

A new approach to optical fiber sensing is proposed and demonstrated that allows for specific measurement even in the presence of strong noise from undesired environmental perturbations. A deep neural network model is trained to statistically learn the relation of the complex optical interference output from a multimode optical fiber (MMF) with respect to a measurand of interest while discriminating the noise. This technique negates the need to carefully shield against, or compensate for, undesired perturbations, as is often the case for traditional optical fiber sensors. This is achieved entirely in software without any fiber postprocessing fabrication steps or specific packaging required, such as fiber Bragg gratings or specialized coatings. The technique is highly generalizable, whereby the model can be trained to identify any measurand of interest within any noisy environment provided the measurand affects the optical path length of the MMF’s guided modes. We demonstrate the approach using a sapphire crystal optical fiber for temperature sensing under strong noise induced by mechanical vibrations, showing the power of the technique not only to extract sensing information buried in strong noise but to also enable sensing using traditionally challenging exotic materials.
Histone modification dynamics at H3K27 are associated with altered transcription of in planta induced genes in Magnaporthe oryzae
Authors: Zhang Wei , Huang Jun , Cook David E.
Published: February 2021

Transcriptional dynamic in response to environmental and developmental cues are fundamental to biology, yet many mechanistic aspects are poorly understood. One such example is fungal plant pathogens, which use secreted proteins and small molecules, termed effectors, to suppress host immunity and promote colonization. Effectors are highly expressedin plantabut remain transcriptionally repressedex planta, but our mechanistic understanding of these transcriptional dynamics remains limited. We tested the hypothesis that repressive histone modification at H3-Lys27 underlies transcriptional silencingex planta, and that exchange for an active chemical modification contributes to transcription ofin plantainduced genes. Using genetics, chromatin immunoprecipitation and sequencing and RNA-sequencing, we determined that H3K27me3 provides significant local transcriptional repression. We detail how regions that lose H3K27me3 gain H3K27ac, and these changes are associated with increased transcription. Importantly, we observed that manyin plantainduced genes were marked by H3K27me3 during axenic growth, and detail how altered H3K27 modification influences transcription. ChIP-qPCR duringin plantagrowth suggests that H3K27 modifications are generally stable, but can undergo dynamics at specific genomic locations. Our results support the hypothesis that dynamic histone modifications at H3K27 contributes to fungal genome regulation and specifically contributes to regulation of genes important during host infection.
Costs and outcomes of active and passive case detection for visceral leishmaniasis (Kala-Azar) to inform elimination strategies in Bihar, India
Authors: Dial Natalie J. , Medley Graham F. , Croft Simon L. , Mahapatra Tanmay , Priyamvada Khushbu , Sinha Bikas , Palmer Lucy , Terris-Prestholt Fern
Published: February 2021

Background

Effective case identification strategies are fundamental to capturing the remaining visceral leishmaniasis (VL) cases in India. To inform government strategies to reach and sustain elimination benchmarks, this study presents costs of active- and passive- case detection (ACD and PCD) strategies used in India’s most VL-endemic state, Bihar, with a focus on programme outcomes stratified by district-level incidence.

Methods

Expenditure analysis was complemented by onsite micro-costing to compare the cost of PCD in hospitals alongside index case-based ACD and a combination of blanket (house-to-house) and camp ACD from January to December 2018. From the provider’s perspective, a cost analysis evaluated the overall programme cost of each activity, the cost per case detected, and the cost of scaling up ACD.

Results

During 2018, index case-based ACD, blanket and camp ACD, and PCD reported 1,497, 131, and 1,983 VL-positive cases at a unit cost of $522.81, $4,186.81, and $246.79, respectively. In high endemic districts, more VL cases were identified through PCD while in meso- and low-endemic districts more cases were identified through ACD. The cost of scaling up ACD to identify 3,000 additional cases ranged from $1.6–4 million, depending on the extent to which blanket and camp ACD was relied upon.

Conclusion

Cost per VL test conducted (rather than VL-positive case identified) may be a better metric estimating unit costs to scale up ACD in Bihar. As more VL cases were identified in meso-and low-endemic districts through ACD than PCD, health authorities in India should consider bolstering ACD in these areas. Blanket and camp ACD identified fewer cases at a higher unit cost than index case-based ACD. However, the value of detecting additional VL cases early outweighs long-term costs for reaching and sustaining VL elimination benchmarks in India.
Survival outcomes are associated with genomic instability in luminal breast cancers
Authors: King Lydia , Flaus Andrew , Holian Emma , Golden Aaron
Published: February 2021

Breast cancer is the leading cause of cancer related death among women. Breast cancers are generally diagnosed and treated based on clinical and histopathological features, along with subtype classification determined by the Prosigna Breast Cancer Prognostic Gene Signature Assay (also known as PAM50). Currently the copy number alteration (CNA) landscape of the tumour is not considered. We set out to examine the role of genomic instability (GI) in breast cancer survival since CNAs reflect GI and correlate with survival in other cancers. We focused on the 70% of breast cancers classified as luminal and carried out a comprehensive survival and association analysis using Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) data to determine whether CNA Score Quartiles derived from absolute CNA counts are associated with survival. Analysis revealed that patients diagnosed with luminal A breast cancer have a CNA landscape associated with disease specific survival, suggesting that CNA Score can provide a statistically robust prognostic factor. Furthermore, stratification of patients into subtypes based on gene expression has shown that luminal A and B cases overlap, and it is in this region we largely observe luminal A cases with reduced survival outlook. Therefore, luminal A breast cancer patients with quantitatively elevated CNA counts may benefit from more aggressive therapy. This demonstrates how individual genomic landscapes can facilitate personalisation of therapeutic interventions to optimise survival outcomes.
Promoting sensitive parenting in ‘at-risk’ mothers and fathers: A UK outcome study of Mellow Babies, a group-based early intervention program for parents and their babies
Authors: Raouna Aigli , Malcolm Ruaridh , Ibrahim Raquib , MacBeth Angus
Published: February 2021

Background

The objective of this study was to evaluate the effectiveness of Mellow Babies (MB) in the UK. MB is a 14-week early parenting intervention program that is delivered in groups and is targeted at ‘at-risk’ parents (both mothers and fathers) and their babies up to 18 months old.

Method

The study used a pragmatic pre-post intervention design. Outcomes were parental mental health, parenting confidence, quality of life, socio-emotional development of children, and perceived parent-child relationship. Fifteen groups representing n = 91 parent-baby dyads were recruited across the UK between 2017–2018. The sample consisted of 10 Mellow Mums groups (70 mother-baby dyads) and 5 Mellow Dads groups (21 father-baby dyads). Intention-to-treat and ‘completer’ analyses were performed.

Results

Findings suggest short-term positive outcomes for parents attending MB. Completion of the program was associated with significant improvements in anxiety and overall wellbeing, parenting confidence, and perceived closeness of the parent-child relationship. The significance of these improvements, except for parenting confidence, was maintained in the intention-to-treat analysis. MB engaged and retained a high proportion of parents who could be considered ‘at-risk’ and benefitted fathers and mothers attending the intervention equally.

Conclusions

This is the first prospective study to explore MB participation for both mothers and fathers and to indicate engagement and potential benefits specifically for ‘at-risk’ parents. Findings further demonstrate the effectiveness of MB as an early intervention program for parents experiencing psychosocial difficulties. Replication by studies using a contrast or control group also incorporating follow-up data would further improve the evidence base for MB.
Multidisciplinary discovery of ancient restoration using a rare mud carapace on a mummified individual from late New Kingdom Egypt
Authors: Sowada Karin , Power Ronika K. , Jacobsen Geraldine , Murphy Timothy , McClymont Alice , Bertuch Fiona , Jenkinson Andrew , Carruthers Jacinta , Magnussen John
Published: February 2021

CT scans of an unnamed mummified adult from Egypt, now in the Chau Chak Wing Museum, University of Sydney (NMR.27.3), reveal it to be fully sheathed in a mud shell or carapace, exposing a mortuary treatment not previously documented in the Egyptian archaeological record. The carapace was placed between layers of linen wrappings thus it was not externally visible. Radiocarbon dating of textile samples provide a range of c.1370–1113 cal BC (95.4% probability), with a median date of 1207 cal BC. When assessed against mummification techniques of the era, the individual is placed in the late 19th–20th Dynasty, at the later end of this date range. Multi-proxy analysis including μ-XRF and Raman spectroscopy of carapace fragments from the head area revealed it to consist of three layers, comprising a thin base layer of mud, coated with a white calcite-based pigment and a red-painted surface of mixed composition. Whether the whole surface of the carapace was painted red is unknown. The carapace was a form of ancient conservation applied subsequent to post-mortem damage to the body, intended to reconfigure the body and enable continued existence of the deceased in the afterlife. The carapace can also be interpreted as a form of elite emulation imitating resin shells found within the wrappings of royal bodies from this period.
One size does not fit all: Assuming the same normal body temperature for everyone is not justified
Authors: Diamond Adele , Lye Carolyn T. , Prasad Deepali , Abbott David
Published: February 2021

Despite the increasing personalization of medicine, surprisingly ~37.0°C (98.6°F) continues as the estimate of normal temperature. We investigated between-subject and within-subject thermal variability, whether a significant percentage of individuals have a low mean oral temperature, and whether these differ by sex, age, time of day, ethnicity, body mass index (BMI), or menstrual phase. Oral temperature was measured by Life Brand® Fast-Read Digital Oral Thermometers and sampled 14 times over two weeks, seven morning and seven evening readings. The volunteer sample consisted of 96 adults (42 men, 54 women; 27 couples, 42 singletons), ages 18–67 years. We found sizeable individual differences in body temperature and that the normal temperature of many individuals is considerably lower than 37.0°C (98.6°F). Mean temperatures ranged from 35.2°C (95.4°F) to 37.4°C (99.3°F). The mean temperature across all participants was 36.1°C (97.0°F)—lower than most studies have reported, consistent with recent evidence of temperature declining over decades. 77% had mean temperatures at least 0.55°C (1°F) lower than 37.0°C (98.6°F). Mean temperature did not differ by age, but women had higher temperatures than men, even within a couple with room temperature and warmth of clothing equated. Although oral temperature varied widely across individuals, it showed marked stability within individuals over days. Variability of temperature over days did not differ by sex, but was larger among younger adults. Using 37.0°C (98.6°F) as the assumed normal temperature for everyone can result in healthcare professionals failing to detect a serious fever in individuals with a low normal temperature or obtaining false negatives for those individuals when using temperature to screen for COVID-19, mistaking their elevated temperature as normal. Some have called for lowering the estimate of normal temperature slightly (e.g., 0.2°C [0.36°F]). That still seems an overly high estimate. More important, using any standardized “normal” temperature will lead to errors for many people. Individual differences are simply too great. Personalizing body temperature is needed. Temperature could be measured at yearly doctor visits, as blood pressure is now. That would be simple to implement. Since our results show marked thermal stability within an individual, sampling temperature only once yearly could provide an accurate indication of a person’s normal temperature at that time of day. Such records over time would also provide a more accurate understanding of how temperature changes over the lifespan.
Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study
Authors: Niriella Madunil Anuk , Ediriweera Dileepa Senajith , Kasturiratne Anuradhani , De Silva Shamila Thivanshi , Dassanayaka Anuradha Supun , De Silva Arjuna Priyadarshin , Kato Norihiro , Pathmeswaran Arunasalam , Wickramasinghe Ananda Rajitha , de Silva Hithanadura Janaka
Published: February 2021

Background

The term “metabolic (dysfunction)-associated fatty liver disease” (MAFLD) is suggested alternative for “non-alcoholic fatty liver disease” (NAFLD), as it better reflects metabolic dysfunction. No study has compared outcomes of the two diagnostic criteria.

Methods

In an ongoing, community-based, cohort-study in suburban Sri Lanka, participants were randomly selected in 2007. They were reassessed in 2014 to evaluate new-onset metabolic traits (MTs) and cardiovascular-events (CVEs). Baseline characteristics, MTs and CVEs after 7-years were compared in NAFLD and MAFLD and vs. controls. Similarly, we compared these parameters in those excluded by the NAFLD definition but captured by the MAFLD definition and vice versa, and vs. controls.

Findings

Of 2985 recruited in 2007, 940 (31.5%) had NAFLD, 990 (33.1%) had MAFLD and 362 (12.1%) were controls. When compared to NAFLD, MAFLD captured an additional 2.9% and lost 1.3% individuals. At baseline, anthropometric and metabolic traits were similar in NAFLD and MAFLD. At follow-up in 7-years, the risk of having new-onset MTs and fatal/non-fatal CVEs were similar in the groups, but were significantly higher compared to controls. Those excluded by the NAFLD definition but captured by the MAFLD definition showed higher baseline MTs compared to those excluded by the MAFLD definition but captured by the NAFLD definition, and had substantially higher risk for having new-onset MTs and CVEs compared to controls.

Interpretation

Although NAFLD and MAFLD had similar MTs at baseline, and similar outcomes after 7-years, those who were excluded by the NAFLD definition but captured by the MAFLD definition seem at higher risk of adverse outcomes than those excluded by the MAFLD definition but captured by the NAFLD definition. Although the increase in the index population was small, redefining NAFLD as MAFLD seemed to improve clinical utility.
Exploratory study on the psychological impact of COVID-19 on the general Brazilian population
Authors: Serafim Antonio P. , Durães Ricardo S. S. , Rocca Cristiana C. A. , Gonçalves Priscila D. , Saffi Fabiana , Cappellozza Alexandre , Paulino Mauro , Dumas-Diniz Rodrigo , Brissos Sofia , Brites Rute , Alho Laura , Lotufo-Neto Francisco
Published: February 2021

The COVID-19 pandemic has become one of the main international concerns regarding its impact on mental health. The present study aims to investigate the prevalence of depression, anxiety, and stress symptoms, and behavioral aspects amidst the COVID-19 pandemic in a Brazilian population. An online survey was administered from May 22 to June 5, 2020 using a questionnaire comprising of sociodemographic information, the Depression, Anxiety, and Stress Scale (DASS-21), and the Coping Strategies Inventory. Participants comprised 3,000 people from Brazil’s 26 states and the Federal District, with an average age of 39.8 years, women (83%), married (50.6%), graduates (70.1%) and employees (46.7%). Some contracted the virus (6.4%) and had dead friends or relatives (22.7%). There was more consumption of drugs, tobacco, medication, and food (40.8%). Almost half of participants expressed symptoms of depression (46.4%), anxiety (39.7%), and stress (42.2%). These were higher in women, people without children, students, patients with chronic diseases, and people who had contact with others diagnosed with COVID-19. The existence of a group more vulnerable to situations with a high stress burden requires greater attention regarding mental health during and after the pandemic. That said, it should be emphasized that these findings are preliminary and portray a moment still being faced by many people amid the pandemic and quarantine measures. Therefore, we understand that the magnitude of the impacts on mental health will only be more specific with continuous studies after total relaxation of the quarantine.
Mycoplasma agassizii, an opportunistic pathogen of tortoises, shows very little genetic variation across the Mojave and Sonoran Deserts
Authors: Luzuriaga-Neira Agusto , Sandmeier Franziska C. , Weitzman Chava L. , Tracy C. Richard , Bauschlicher Shalyn N. , Tillett Richard L. , Alvarez-Ponce David
Published: February 2021

Mycoplasma agassizii is a common cause of upper respiratory tract disease in Mojave desert tortoises (Gopherus agassizii). So far, only two strains of this bacterium have been sequenced, and very little is known about its patterns of genetic diversity. Understanding genetic variability of this pathogen is essential to implement conservation programs for their threatened, long-lived hosts. We used next generation sequencing to explore the genomic diversity of 86 cultured samples of M. agassizii collected from mostly healthy Mojave and Sonoran desert tortoises in 2011 and 2012. All samples with enough sequencing coverage exhibited a higher similarity to M. agassizii strain PS6T (collected in Las Vegas Valley, Nevada) than to strain 723 (collected in Sanibel Island, Florida). All eight genomes with a sequencing coverage over 2x were subjected to multiple analyses to detect single-nucleotide polymorphisms (SNPs). Strikingly, even though we detected 1373 SNPs between strains PS6T and 723, we did not detect any SNP between PS6T and our eight samples. Our whole genome analyses reveal that M. agassizii strain PS6T may be present across a wide geographic extent in healthy Mojave and Sonoran desert tortoises.
A systematic review and activation likelihood estimation meta-analysis of the central innervation of the lower urinary tract: Pelvic floor motor control and micturition
Authors: Groenendijk Ilse M. , Mehnert Ulrich , Groen Jan , Clarkson Becky D. , Scheepe Jeroen R. , Blok Bertil F. M.
Published: February 2021

Purpose

Functional neuroimaging is a powerful and versatile tool to investigate central lower urinary tract (LUT) control. Despite the increasing body of literature there is a lack of comprehensive overviews on LUT control. Thus, we aimed to execute a coordinate based meta-analysis of all PET and fMRI evidence on descending central LUT control, i.e. pelvic floor muscle contraction (PFMC) and micturition.

Materials and methods

A systematic literature search of all relevant libraries was performed in August 2020. Coordinates of activity were extracted from eligible studies to perform an activation likelihood estimation (ALE) using a threshold of uncorrected p <0.001.

Results

20 of 6858 identified studies, published between 1997 and 2020, were included. Twelve studies investigated PFMC (1xPET, 11xfMRI) and eight micturition (3xPET, 5xfMRI). The PFMC ALE analysis (n = 181, 133 foci) showed clusters in the primary motor cortex, supplementary motor cortex, cingulate gyrus, frontal gyrus, thalamus, supramarginal gyrus, and cerebellum. The micturition ALE analysis (n = 107, 98 foci) showed active clusters in the dorsal pons, including the pontine micturition center, the periaqueductal gray, cingulate gyrus, frontal gyrus, insula and ventral pons. Overlap of PFMC and micturition was found in the cingulate gyrus and thalamus.

Conclusions

For the first time the involved core brain areas of LUT motor control were determined using ALE. Furthermore, the involved brain areas for PFMC and micturition are partially distinct. Further neuroimaging studies are required to extend this ALE analysis and determine the differences between a healthy and a dysfunctional LUT. This requires standardization of protocols and task-execution.
Diatom community structure in relation to environmental factors in human influenced rivers and streams in tropical Africa
Authors: Shibabaw Tebkew , Beyene Abebe , Awoke Aymere , Tirfie Mulat , Azage Muluken , Triest Ludwig
Published: February 2021

The contemporaneous effect of natural and anthropogenic factors involved in a watershed contribution to the seasonal and spatial variation of diatom community composition is widely discussed in the scientific literature. Yet, there is a paucity of scientific evidence indicating the effect of these factors on diatoms in tropical African regions characterized by distinct dry and wet seasons and season associated human activities like rainfed agriculture are commonly practiced. We applied multivariate techniques to determine the spatio-temporal drivers of diatom assemblage and diatom species richness in human influenced rivers and streams in Ethiopia. We simultaneously collected water and diatom samples from 24 sampling points during the wet (July) and dry (February) seasons. Both water and diatom samples were processed following standard procedures. We identified 169 species belonging to 45 genera in the studied lotic systems. We found that both season and land use factors were important in defining diatom composition (PERMANOVA, p<0.05) and species richness (ANOVA, p<0.05) patterns. Diatom community composition was driven by conductivity, dissolved oxygen, pH, and turbidity parameters (Monte Carlo permutation test, p<0.05). Besides, diatom species richness was driven by dissolved oxygen, soluble reactive phosphorus, and turbidity (GLMM, p<0.05). The study highlighted physicochemical parameters influenced by seasonal variation and human activity determined the composition of diatoms. This implies that the unique feature of heavy rain during the rainy season in the region followed by extensive flooding aggravated by the steep slope from the highlands to the lowlands plays a major role in shaping the diatom autecology in the region. Therefore, in applying biomonitoring in such regions considering the effect of runoff and dilution is imperative.