bluuebunny/crossref_metadata_2025 huggingface dataset:
Paper Origami‐Inspired Design and Actuation of DNA Nanomachines with Complex Motions
Authors: Zhou Lifeng , Marras Alexander E. , Huang Chao‐Min , Castro Carlos E. , Su Hai‐Jun
Published: October 2018

Significant progress in DNA nanotechnology has accelerated the development of molecular machines with functions like macroscale machines. However, the mobility of DNA self‐assembled nanorobots is still dramatically limited due to challenges with designing and controlling nanoscale systems with many degrees of freedom. Here, an origami‐inspired method to design transformable DNA nanomachines is presented. This approach integrates stiff panels formed by bundles of double‐stranded DNA connected with foldable creases formed by single‐stranded DNA. To demonstrate the method, a DNA version of the paper origami mechanism called a waterbomb base (WBB) consisting of six panels connected by six joints is constructed. This nanoscale WBB can follow four distinct motion paths to transform between five distinct configurations including a flat square, two triangles, a rectangle, and a fully compacted trapezoidal shape. To achieve this, the sequence specificity of DNA base‐pairing is leveraged for the selective actuation of joints and the ion‐sensitivity of base‐stacking interactions is employed for the flattening of joints. In addition, higher‐order assembly of DNA WBBs into reconfigurable arrays is achieved. This work establishes a foundation for origami‐inspired design for next generation synthetic molecular robots and reconfigurable nanomaterials enabling more complex and controllable motion.
Polymersomes: Breaking the Glass Ceiling?
Authors: Chidanguro Tamuka , Ghimire Elina , Liu Cheyenne H. , Simon Yoan C.
Published: October 2018

Polymer vesicles, also known as polymersomes, have garnered a lot of interest even before the first report of their fabrication in the mid‐1990s. These capsules have found applications in areas such as drug delivery, diagnostics and cellular models, and are made via the self‐assembly of amphiphilic block copolymers, predominantly with soft, rubbery hydrophobic segments. Comparatively, and despite their remarkable impermeability, glassy polymersomes (GPs) have been less pervasive due to their rigidity, lack of biodegradability and more restricted fabrication strategies. GPs are now becoming more prominent, thanks to their ability to undergo stable shape‐change (e.g., into non‐spherical morphologies) as a response to a predetermined trigger (e.g., light, solvent). The basics of block copolymer self‐assembly with an emphasis on polymersomes and GPs in particular are reviewed here. The principles and advantages of shape transformation of GPs as well as their general usefulness are also discussed, together with some of the challenges and opportunities currently facing this area.
Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons
Authors: Faridi Ava , Sun Yunxiang , Okazaki Yutaka , Peng Guotao , Gao Jie , Kakinen Aleksandr , Faridi Pouya , Zhao Mei , Javed Ibrahim , Purcell Anthony W. , Davis Thomas P. , Lin Sijie , Oda Reiko , Ding Feng , Ke Pu Chun
Published: October 2018

Amyloid fibrils generally display chirality, a feature which has rarely been exploited in the development of therapeutics against amyloid diseases. This study reports, for the first time, the use of mesoscopic chiral silica nanoribbons against the in vivo amyloidogenesis of human islet amyloid polypeptide (IAPP), the peptide whose aggregation is implicated in type 2 diabetes. The thioflavin T assay and transmission electron microscopy show accelerated IAPP fibrillization through elimination of the nucleation phase and shortening of the elongation phase by the nanostructures. Coarse‐grained simulations offer complementary molecular insights into the acceleration of amyloid aggregation through their nonspecific binding and directional seeding with the nanostructures. This accelerated IAPP fibrillization translates to reduced toxicity, especially for the right‐handed silica nanoribbons, as revealed by cell viability, helium ion microscopy, as well as zebrafish embryo survival, developmental, and behavioral assays. This study has implicated the potential of employing chiral nanotechnologies against the mesoscopic enantioselectivity of amyloid proteins and their associated diseases.
Wireless, Battery‐Free Epidermal Electronics for Continuous, Quantitative, Multimodal Thermal Characterization of Skin
Authors: Krishnan Siddharth R. , Su Chun‐Ju , Xie Zhaoqian , Patel Manish , Madhvapathy Surabhi R. , Xu Yeshou , Freudman Juliet , Ng Barry , Heo Seung Yun , Wang Heling , Ray Tyler R. , Leshock John , Stankiewicz Izabela , Feng Xue , Huang Yonggang , Gutruf Philipp , Rogers John A.
Published: October 2018

Precise, quantitative measurements of the thermal properties of human skin can yield insights into thermoregulatory function, hydration, blood perfusion, wound healing, and other parameters of clinical interest. The need for wired power supply systems and data communication hardware limits, however, practical applicability of existing devices designed for measurements of this type. Here, a set of advanced materials, mechanics designs, integration schemes, and wireless circuits is reported as the basis for wireless, battery‐free sensors that softly interface to the skin to enable precise measurements of its temperature and thermal transport properties. Calibration processes connect these parameters to the hydration state of the skin, the dynamics of near‐surface flow through blood vessels and implanted catheters, and to recovery processes following trauma. Systematic engineering studies yield quantitative metrics in precision and reliability in real‐world conditions. Evaluations on five human subjects demonstrate the capabilities in measurements of skin hydration and injury, including examples of continuous wear and monitoring over a period of 1 week, without disrupting natural daily activities.
Spontaneous Reshaping and Splitting of AgCl Nanocrystals under Electron Beam Illumination
Authors: Tian Xuezeng , Anand Utkarsh , Mirsaidov Utkur , Zheng Haimei
Published: October 2018

AgCl is photosensitive and thus often used as micromotors. However, the dynamics of individual AgCl nanoparticle motion in liquids upon illumination remains elusive. Here, using liquid cell transmission electron microscope (TEM), AgCl nanocrystals reshaping and splitting spontaneously in an aqueous solution under electron beam illumination are observed. It is found that the AgCl nanocrystals are negatively charged in the liquid environment, where the charge induces a repulsive Coulomb force that reshapes and stretches those nanocrystals. Upon extensive stretching, the AgCl nanocrystal splits into small nanocrystals and each nanocrystal retracts back into cuboid shapes due to the cohesive surface. This analysis shows that each nanocrystal maintains a single crystal rocksalt structure during splitting. The splitting of AgCl nanocrystals is analogous to the electrified liquid droplets or other reported the Coulomb fission phenomenon, but with distinctive structural properties. Revealing of the dynamic behavior of AgCl nanocrystals opens the opportunity to explore their potential applications as actuators for nanodevices.
A Gelatin Microdroplet Platform for High‐Throughput Sorting of Hyperproducing Single‐Cell‐Derived Microalgal Clones
Authors: Li Ming , van Zee Mark , Riche Carson T. , Tofig Bobby , Gallaher Sean D. , Merchant Sabeeha S. , Damoiseaux Robert , Goda Keisuke , Di Carlo Dino
Published: October 2018

Microalgae are an attractive feedstock organism for sustainable production of biofuels, chemicals, and biomaterials, but the ability to rationally engineer microalgae to enhance production has been limited. To enable the evolution‐based selection of new hyperproducing variants of microalgae, a method is developed that combines phase‐transitioning monodisperse gelatin hydrogel droplets with commercial flow cytometric instruments for high‐throughput screening and selection of clonal populations of cells with desirable properties, such as high lipid productivity per time traced over multiple cell cycles. It is found that gelatin microgels enable i) the growth and metabolite (e.g., chlorophyll and lipids) production of single microalgal cells within the compartments, ii) infusion of fluorescent reporter molecules into the hydrogel matrices following a sol–gel transition, iii) selection of high‐producing clonal populations of cells using flow cytometry, and iv) cell recovery under mild conditions, enabling regrowth after sorting. This user‐friendly method is easily integratable into directed cellular evolution pipelines for strain improvement and can be adopted for other applications that require high‐throughput processing, e.g., cellular secretion phenotypes and intercellular interactions.
Core–Shell Hybrid Nanowires with Protein Enabling Fast Ion Conduction for High‐Performance Composite Polymer Electrolytes
Authors: Fu Xuewei , Wang Yu , Fan Xin , Scudiero Louis , Zhong Wei‐Hong
Published: October 2018

Incorporating nanofillers is one of the promising approaches for simultaneously boosting the ionic conductivity and mechanical properties of solid polymer electrolytes (SPEs). However, effectively creating faster ion‐conduction pathways via nanofillers still remains a big challenge. Herein, core–shell protein–ceramic nanowires for more efficiently building fast ion‐conduction networks in SPEs are reported. The core–shell protein–ceramic nanowires are fabricated via in situ growth of protein coating on the electrospun TiO2 nanowires in a subtly controlled protein‐denaturation process. It is demonstrated that the core–shell protein@TiO2 nanowires effectively facilitate ion‐conduction. As a result, the ionic conductivity, mechanical properties, electrochemical stability, and even Li+ transference number of the SPEs with core–shell protein@TiO2 nanowires are significantly enhanced. The contributions from the 1D morphology of the protein@TiO2 nanowires, and more importantly, the favorable protein structure for further promoting ion‐conduction at the polymer–filler interfaces are analyzed. It is believed that the protein plays a pivotal role in dissociating lithium salts, which benefits from the strong interactions between protein and ions, making the protein serve as a unique “natural channel” for rapidly conducting Li+. This study initiates an effective method of promoting ionic conductivity and constructing faster ion‐conduction networks in SPEs via combining bio‐ and nanotechnology.
High‐Motility Visible Light‐Driven Ag/AgCl Janus Micromotors
Authors: Wang Xu , Baraban Larysa , Nguyen Anh , Ge Jin , Misko Vyacheslav R. , Tempere Jacques , Nori Franco , Formanek Petr , Huang Tao , Cuniberti Gianaurelio , Fassbender Jürgen , Makarov Denys
Published: October 2018

Visible light‐driven nano/micromotors are promising candidates for biomedical and environmental applications. This study demonstrates blue light‐driven Ag/AgCl‐based spherical Janus micromotors, which couple plasmonic light absorption with the photochemical decomposition of AgCl. These micromotors reveal high motility in pure water, i.e., mean squared displacements (MSD) reaching 800 µm2 within 8 s, which is 100× higher compared to previous visible light‐driven Janus micromotors and 7× higher than reported ultraviolet (UV) light‐driven AgCl micromotors. In addition to providing design rules to realize efficient Janus micromotors, the complex dynamics revealed by individual and assemblies of Janus motors is investigated experimentally and in simulations. The effect of suppressed rotational diffusion is focused on, compared to UV light‐driven AgCl micromotors, as a reason for this remarkable increase of the MSD. Moreover, this study demonstrates the potential of using visible light‐driven plasmonic Ag/AgCl‐based Janus micromotors in human saliva, phosphate‐buffered saline solution, the most common isotonic buffer that mimics the environment of human body fluids, and Rhodamine B solution, which is a typical polluted dye for demonstrations of photocatalytic environmental remediation. This new knowledge is useful for designing visible light driven nano/micromotors based on the surface plasmon resonance effect and their applications in assays relevant for biomedical and ecological sciences.
Correlation between compressive and tensile strength of old concretes: Applicability of the relationship described in EN 1992‐1‐1
Authors: Weber Michael , Thiele Catherina
Published: October 2018

In the design of new structures, EN 1992‐1‐1 normatively regulates the correlation between the compressive strength and tensile strength of concrete, in accordance with EN 206‐1. However, as there are many time‐ and load‐dependent impacts on existing structures, the relationship described by EN 1992‐1‐1 cannot be assumed without any further observations for existing structures. At the moment, there is no comprehensive investigation on the influences of, for example, subsequent hardening and carbonation on the concrete compressive or tensile strength. The tensile strength of concrete defined in EN 1992‐1‐1 is based on a water storage and a testing age of 28 days. Furthermore, the in‐situ tensile strength is affected by micro‐crack formation cause of internal stresses due to outflow of hydration heat, for example. Generally, there is a different influence of micro‐crack formation on the tensile strength of concrete than on the compressive strength of concrete. The actual value of the in‐situ tensile strength of concrete affects the shear force resistance and the load‐bearing capacity of anchors with concrete cone failure as decisive failure mode. Within the framework of a research project (SWD‐10.08.18.7‐13.01), financed by “Forschungsinitiative Zukunft Bau”, an initiative of the Federal Institute for Research on Building, Urban Affairs and Spatial Development (BBR) structural investigations on the correlation between the compressive and tensile strength of old concretes have been performed. Below, the results of the research project are presented.
Extensive exploration of a novel rat model of Parkinson's disease using partial 6‐hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches
Authors: Vetel Steven , Sérrière Sophie , Vercouillie Johnny , Vergote Jackie , Chicheri Gabrielle , Deloye Jean‐Bernard , Dollé Frédéric , Bodard Sylvie , Tronel Claire , Nadal‐Desbarats Lydie , Lefèvre Antoine , Emond Patrick , Chalon Sylvie
Published: October 2018

Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons constituting the nigrostriatal pathway. Neuroinflammation, related to microglial activation, plays an important role in this process. Exploration of animal models of PD using neuroimaging modalities allows to better understand the pathophysiology of the disease. Here, we fully explored a moderate lesion model in the rat in which 6‐hydroxydopamine was unilaterally delivered in three sites along the striatum. The degenerative process was assessed through in vivo Positron Emission Tomography (PET) imaging and in vitro autoradiographic quantitation of the striatal dopamine transporter (DAT) and immunostaining of tyrosine hydroxylase (TH). The microglial activation was studied through in vitro autoradiographic quantitation of the 18 kDa translocator protein (TSPO) in the striatum and CD11b staining in the SN. In addition, a targeted metabolomics exploration was performed in both these structures using mass spectrometry coupled to HPLC. Our results showed a reproducible decrease in the striatal DAT density associated with a reduction in the number of TH‐positive cells in the SN and striatum, reflecting a robust moderate degeneration of nigrostriatal DA neurons. In addition, we observed strong microglia activation in both the striatum and SN ipsilateral to the lesion, highlighting that this moderate degeneration of DA neurons was associated with a marked neuroinflammation. Our metabolomics studies revealed alterations of specific metabolites and metabolic pathways such as carnitine, arginine/proline, and histidine metabolisms. These results bring new insights in the PD mechanism knowledge and new potential targets for future therapeutic strategies.
Effects of Climate‐Related Stream Factors on Patterns of Individual Summer Growth of Cutthroat Trout
Authors: Uthe P. , Al‐Chokhachy R. , Shepard B. B. , Zale A.V. , Kershner J. L.
Published: October 2018

Coldwater fishes are sensitive to abiotic and biotic stream factors, which can be influenced by climate. Distributions of inland salmonids in North America have declined significantly, with many of the current strongholds located in small headwater systems that may serve as important refugia as climate change progresses. We investigated the effects of discharge, stream temperature, trout biomass, and food availability on summer growth of Yellowstone Cutthroat Trout Oncorhynchus clarkii bouvieri, a species of concern with significant ecological value. Individual size, stream discharge, sample section biomass, and temperature were all associated with growth, but had differing effects on energy allocation. Stream discharge had a positive relationship with growth rates in length and mass; greater rates of prey delivery at higher discharges probably enabled trout to accumulate reserve tissues in addition to structural growth. Temperature effects were positive but not significant, and support in growth models was limited, likely due to the cold thermal regimes of the study area. The strength of the discharge effect on growth suggests that climate adaptation strategies for coldwater fishes that focus solely on thermal characteristics may be misleading and highlights the importance of considering multiple factors, including hydrologic regimes, in conservation planning.
Behavior and Survival of Stocked Trout in Southern Appalachian Mountain Streams
Authors: Flowers H. Jared , Kwak Thomas J. , Fischer Jesse R. , Cope W. Gregory , Rash Jacob M. , Besler Douglas A.
Published: October 2018

Stocking of trout to support recreational fisheries is a common practice among state and federal agencies to meet angling and harvest demands. Success of stocking efforts relies upon fish behavior and survival to maximize the availability of fish to anglers. We quantitatively described the movement behavior and survival of stocked Brook Trout Salvelinus fontinalis, Brown Trout Salmo trutta, and Rainbow Trout Oncorhynchus mykiss in three southern Appalachian Mountain streams in western North Carolina, USA, that were managed under delayed harvest regulations. Hatchery trout were tagged with a combination of PIT tags and radio transmitters (radio tags); stocked into “Delayed Harvest Trout Waters” of the North Toe, East Prong Roaring, and Little rivers; and monitored during the catch‐and‐release season from October to June. Assessed according to river and species, 19–65% of trout emigrated from the delayed harvest study reaches, while 1–29% died within the reaches. The majority of radio‐tagged fish (71%; 59–85% by river) remained within 2 km of the stocking location, whereas 6% migrated over 10 km from the stocking location. Few trout stocked during fall (October and November) were available to anglers the following June due to a combination of migration and mortality. Emigration from delayed harvest study reaches was associated with stocking and high‐flow events. Multi‐state modeling detailed these observations with weekly estimates of migration and survival rates. River‐specific differences in emigration and mortality suggested that emigration was a greater source of trout loss than mortality in all rivers; no pattern related to river size was apparent in emigration, but mortality was greater in small streams. Brook Trout mortality rates were highest among the three species, and large fish of most species showed higher emigration and mortality than catchable‐sized trout. Fisheries managers can apply our results to alter stocking regimes so as to enhance the efficiency of stocking and the acclimation of stocked trout to instream environments.
Interventions supporting baccalaureate achievement of Latinx STEM students matriculating at 2‐year institutions: A systematic review
Authors: Martin Julie P. , Choe Nathan Hyungsok , Halter Jared , Foster Margaret , Froyd Jeffrey , Borrego Maura , Winterer Erica R.
Published: October 2018

Numerous national reports have identified the importance of significantly improving pathways that begin with Latinx students enrolling in 2‐year institutions and ultimately completing baccalaureate degrees in STEM fields at 4‐year institutions. Many programs using multiple interventions have been designed, implemented, and studied to achieve this goal. To synthesize what has been learned from studies of these programs, this article presents a systematic review of published studies of programs designed to support Latinx student success in 2‐year institutions and successful transfer to 4‐year institutions, particularly for STEM majors. A total of 49 quantitative, 9 qualitative, and 16 mixed‐methods studies published as reports, articles, or dissertations since 1980 were identified that met the criteria for the review. Studies covered a wide range of interventions, including mentoring, counseling, advising, study groups, tutoring, scholarships, orientations, career services, undergraduate research, articulation agreements, and transfer programs. Individually, these studies report positive influences on student success outcomes, including 2‐ and 4‐year graduation, transfer to a 4‐year institution, retention, and success in individual courses. However, the number of qualifying studies was surprisingly small, considering the importance of improving success of Latinx students and the length of time during which the problem has been repeatedly emphasized. Few interventions have been undertaken from explicitly assets‐based perspectives or theoretical frameworks. The lack of explicit frameworks underlying interventions—combined with a sole/primary focus on students—suggests many interventions were approached from a deficit‐based perspective. Further, the study found no pattern of replication studies that might confirm effectiveness of potentially promising interventions. Based on our analysis of evaluations presented in the studies, it does not appear that the research community has developed agreed‐upon methods to evaluate commonly agreed‐upon outcomes. Finally, no intervention has been sufficiently supported that widespread implementation could be recommended.
Impact of model‐based science curriculum and instruction on elementary students' explanations for the hydrosphere
Authors: Baumfalk Ben , Bhattacharya Devarati , Vo Tina , Forbes Cory , Zangori Laura , Schwarz Christina
Published: October 2018

Developing scientific literacy about water systems is critical for K‐12 students. However, even with opportunities to build knowledge about the hydrosphere in elementary classrooms, early learners may struggle to understand the water cycle (Forbes et al., ; Gunckel et al., ; Zangori et al., ; Zangori et al., ). Scientific modeling affords opportunities for students to develop representations, make their ideas visible, and generate model‐based explanations for complex natural systems like the water cycle. This study describes a comprehensive evaluation of a 5‐year, design‐based research project focused on the development, implementation, revision, and testing of an enhanced, model‐centered version of the Full Option Science System (FOSS) Water (2005) unit in third grade classrooms. Here, we build upon our previous work (Forbes et al., a; b; Vo et al., ; Zangori et al., ; Zangori et al., ) by conducting a comparative analysis of student outcomes in two sets of classrooms: (1) one implementing the modeling‐enhanced version of the FOSS Water unit developed by the research team (n = 6), and 2) another using the standard, unmodified version of the same curricular unit (n = 5). Results demonstrate that teachers in both conditions implemented the two versions of the curriculum with relative fidelity. On average, students exposed to the modeling‐enhanced version of the curriculum showed greater gains in their model‐based explanations for the hydrosphere. Engagement in scientific modeling allowed students to articulate hydrologic phenomena by (1) identifying various elements that constitute the hydrosphere, (2) describing how these elements influenced the movement of water in the hydrosphere, and (3) demonstrating underlying processes that govern the movement of water in the hydrosphere.
Early career science teacher experiences of social bonds and emotion management
Authors: Bellocchi Alberto
Published: October 2018

High demand for suitably qualified, high‐quality science teachers is undermined by elevated teacher burnout/attrition rates within the early years of teaching. Effective emotion management can alleviate feelings of burnout and is also linked theoretically to sustaining positive social bonds. Scant attention has been directed at the importance of emotion management and social bonds in science education research. This study presents a methodology for studying emotion management and social bonds, delivering novel outcomes that elucidate how these two phenomena are interrelated. Video recordings of classroom interactions and reflective accounts in an early‐career science teacher's ninth grade class were analyzed through a combination of ethnomethodology and interpretive techniques. Situated actions that constitute emotion management at the classroom level impacted the status of bonds between the teacher and one of his students, ultimately leading to a breakdown in their relationship. Results of the study detail how social actions of numerous students and the teacher led to the co‐construction of emotion management and how this impacted social bonds. Theoretical and practical insights about the co‐constructed nature of emotion management and social bonds present novel perspectives that can help to avoid pathologizing the actions of individual students and teachers for sustaining positive social bonds. Implications for science teaching and teacher education are offered. Study outcomes extend previous perspectives on emotion management in science education, which treat emotion management as an individual cognitive phenomenon.
Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D‐galactose induced aging in rats
Authors: Chang Yung‐Ming , Tamilselvi Shanmugam , Lin Hung‐Jen , Tsai Chin‐Chuan , Lin Yueh‐Min , Day Cecilia Hsuan , Viswanadha Vijaya Padma , Chang Hsin‐Nung , Kuo Wei‐Wen , Huang Chih‐Yang
Published: October 2018

Cardiac fibrosis is a common pathophysiological process observed during chronic and stress‐induced acceleration of cardiac aging. Fibrosis is a necessary process during wound healing and tissue repair. However, its deposition in organs would proceed to scarring and organ damage. Here Alpinate Oxyphyllae Fructus (AOF), a Chinese medicine extract was used to protect aging heart from collagen accumulation. About 8 weeks old, male SD rats were randomly divided into (i) Control, (ii) D‐galactose induced aging (IA), (iii) IA + AOF 50 (AOF low, AL), (iv) IA + AOF 100 (AOF medium, AM), (v) IA + AOF 150 (AOF high, AH) mg/kg/day, AOF was administered orally. After 8 weeks rats were sacrificed and hearts were collected. Results showed collagen deposition and up‐regulation of matrix metalloproteinases‐MMP‐2 and ‐9 in D‐galactose‐induced aging rats. Furthermore, western blotting and immunostaining were also confirmed the upregulation of TGF‐β1 mediated fibrosis in aging induced rats. However, collagen deposition and fibrosis were significantly decreased by AOF treatments (AM and AH). AOF treatments salvaged the cardiac fibrosis. Hence, AOF might be a potential therapeutic agent in the prevention of cardiac fibrosis associated with aging. The protective effects of AOF might have promising results in anti‐aging treatments.
Multi-Agent Systems for Resource Allocation and Scheduling in a Smart Grid
Authors: Nair Arun Sukumaran , Hossen Tareq , Campion Mitch , Selvaraj Daisy Flora , Goveas Neena , Kaabouch Naima , Ranganathan Prakash
Published: October 2018

With the increasing integration of Distributed Energy Resources (DER) in the power grid, a decentralized approach becomes essential for scheduling and allocation of resources in a smart grid. Economic Dispatch (ED) and Unit Commitment (UC) are the two major resource allocation problems that play critical role in the safe and stable operation of a grid system. The uncertainty associated with renewable energy sources have made the resource allocation problems even more challenging for grid operators. The future grid will have a higher generation mix of renewable energy sources and a large load of Electrical vehicles, with the possibility of bi-directional power flow. This complex smart grid system necessitates the development of a decentralized approach to resource allocation problem, which allows inter-node communication and decision making. Multi-agent systems (MAS) is a promising platform to decentralize the traditional centralized resource allocation aspects of smart grid. This paper presents a comprehensive literature review on the application of MAS to Economic Dispatch (ED) and Unit Commitment (UC) in smart grids.
Halogen substitution effects on optical and electrical properties in 3D molecular perovskites
Authors: Zhao Meng-Meng , Zhou Lin , Shi Ping-Ping , Zheng Xuan , Chen Xiao-Gang , Gao Ji-Xing , Geng Fu-Juan , Ye Qiong , Fu Da-Wei
Published: October 2018

In 1 the SHG effect was observed, and remarkably 2 represents the first 3D ferroelastic material characterized by two ferroelastic phases.
TiO2-based heterojunction photocatalysts for photocatalytic reduction of CO2into solar fuels
Authors: Wei Longfu , Yu Changlin , Zhang Qinghong , Liu Hong , Wang Ye
Published: October 2018

Recent advances in the photocatalytic reduction of CO2into solar fuels using TiO2-based heterojunction photocatalysts have been highlighted.
IL-9 promotes the pathogenesis of ulcerative colitis through STAT3/SOCS3 signaling
Authors: Tian Linglin , Li Yuan , Zhang Jian , Chang Ruqi , Li Jianhong , Huo Lijuan
Published: October 2018

Ulcerative colitis (UC) is a chronic condition in which the overreacting immune system may play an important role. It has been confirmed that the interleukin (IL) 9 (IL-9) participates in the pathogenesis of UC but the molecular mechanism is not fully illustrated. Here, we show that levels of peripheral blood cytokines IL-9, IL-8, IL-10, IL-6, IL-1β, IL-12, and tumor necrosis factor (TNF) were higher in patients with UC than normal control, and serum and local IL-9 levels were positively correlated with the disease activity grade. Moreover, IL-9 stimulation inhibited suppressor of cytokine signaling 3 (SOCS3) expression and wound healing ability in colonic epithelial cells and promoted the phosphorylation level of signal transducers and activators of transcription 3 (STAT3). And IL-9 stimulation promoted claudin-2 expression while inhibited claudin-3 and occludin expression. Furthermore, SOCS3 overexpression rescued the IL-9-induced effects. Altogether, IL-9 participates in the pathogenesis of UC through STAT3/SOCS3 signaling pathway and has the potential to serve as a possible therapeutic candidate in patients with UC.
Functional analysis of mammalian phospholipase D enzymes
Authors: Panda Aniruddha , Thakur Rajan , Krishnan Harini , Naik Amruta , Shinde Dhananjay , Raghu Padinjat
Published: October 2018

Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Mammalian genomes contain two genes encoding distinct isoforms of PLD in contrast with invertebrate genomes that include a single PLD gene. However, the significance of two genes within a genome encoding the same biochemical activity remains unclear. Recently, loss of function in the only PLD gene in Drosophila was reported to result in reduced PA levels and a PA-dependent collapse of the photoreceptor plasma membrane due to defects in vesicular transport. Phylogenetic analysis reveals that human PLD1 (hPLD1) is evolutionarily closer to dPLD than human PLD2 (hPLD2). In the present study, we expressed hPLD1 and hPLD2 in Drosophila and found that while reconstitution of hPLD1 is able to completely rescue retinal degeneration in a loss of function dPLD mutant, hPLD2 was less effective in its ability to mediate a rescue. Using a newly developed analytical method, we determined the acyl chain composition of PA species produced by each enzyme. While dPLD was able to restore the levels of most PA species in dPLD3.1 cells, hPLD1 and hPLD2 each were unable to restore the levels of a subset of unique species of PA. Finally, we found that in contrast with hPLD2, dPLD and hPLD1 are uniquely distributed to the subplasma membrane region in photoreceptors. In summary, hPLD1 likely represents the ancestral PLD in mammalian genomes while hPLD2 represents neofunctionalization to generate PA at distinct subcellular membranes.
In situ study of field emission vacuum breakdown of individual multi‐wall carbon nanotube
Authors: Liu Zhenkun , Zhang Yu , Zhao Peng , Ye Yuan , Chen Jun , Xu Ningsheng , Deng Shaozhi
Published: October 2018

The vacuum breakdown critical condition of individual carbon nanotube (CNT) during field emission was investigated experimentally using the in‐situ field emission combined scanning electron microscope system. The results showed that the critical breakdown electric field of CNT was related to its length and diameter. CNT which has a shorter length and larger diameter could bear higher electric field. The underlying mechanism was attributed to the heat dissipation ability of CNT. A smaller length and larger diameter CNT has better heat dissipation. The results met with the theoretical calculations and helped to understand the physics mechanism of vacuum breakdown of CNT during field emission in a visual perspective.
Fatty acid composition of young dairy bull beef as affected by breed type, production treatment, and relationship to sensory characteristics
Authors: Nian Yingqun , Allen Paul , Harrison Sabine M. , Brunton Nigel P. , Prendiville Robert , Kerry Joseph P.
Published: October 2018

The number of male calves from the Irish dairy herd has increased following the abolition of EU milk quotas in 2015. This is a new resource for the industry, and they can be reared economically to produce meat of acceptable eating quality with optimal fatty acid (FA) profile. The effects of breed and feeding treatment on the FA profile of the longissimus thoracis (LT) muscles of young dairy bulls (n = 69) of Holstein–Friesian and Jersey × Holstein–Friesian were evaluated. The relationship between FA composition and sensory characteristics was also investigated. Bulls were offered either 1 or 2 kg of concentrates at pasture during the first grazing season. Bulls finished on silage with 5 kg of concentrates or on ad libitum concentrates were slaughtered at 15 months of age, while bulls slaughtered at 19 months were fed either ad libitum pasture or pasture with 5 kg of concentrates during a second grazing season and finished on pasture with 5 kg of concentrates or ad libitum concentrates. Pasture-finished 19-month-old bulls had higher relative proportions of C18:0 (P < 0.001), C20:5n3 (eicosapentaenoic acid; P < 0.001), C18:2n6c (P < 0.05), C20:4n6 (P < 0.01), and total n-3 (P < 0.001) and n-6 polyunsaturated FAs (P < 0.05), but reduced C14:0, C16:0, C14:1, C16:1 and total monounsaturated FA (P < 0.001) proportions than in other production treatments. The silage-based finishing system of 15-month-old bulls increased the relative proportions of C15:0 (P < 0.01), C18:0 (P < 0.001) and total saturated FA (P < 0.01), but decreased the proportions of C20:3n6 (P < 0.05) and total unsaturated FA (P < 0.01) compared with the ad libitum-concentrate finishing system. However, the feeding system of the first or second grazing seasons had limited effects on the FA profile. Jersey × Holstein–Friesian breed type had higher relative proportions of C14:1 and C16:1 (P < 0.05), but lower C15:0 (P < 0.01), C17:0 (P < 0.001) and C17:1 (P < 0.01) proportions than did Holstein–Friesian beef. Slaughter age did not affect the FA profile. Monounsaturated FA, C14:0 and C16:0 proportions were positively (P < 0.05) correlated, but polyunsaturated FA proportion was negatively (P < 0.05) correlated with intramuscular fat content, sensory roast beef aroma, flavour, flavour length, juiciness, initial tenderness and ease of disintegration scores. Finishing system and slaughter weight were well discriminated on the basis of FA relative proportions by canonical discriminant analysis.
Immunohaematological status and mRNA expression of the genes encoding interleukin-6, nuclear-factor kappa B, and tumor-necrosis factor-α in the spleen of broilers supplemented with dietary rutin
Authors: Awad Ashraf , Zaglool Asmaa W. , Khalil Samah R.
Published: October 2018

Rutin, also known as vitamin P or rutoside, has been explored for many pharmacological activities. Apples, tea leaves, and many other plants contain rutin as one of the active constituents. Haematological, immunological indices and the expression of inflammatory cytokine genes in spleen tissue were assessed to investigate the influence of different levels of dietary rutin supplement (0.25, 0.5, or 1 g/kg diet) on the immune response of broilers. After 6 weeks, rutin-fed chickens showed an increase in the haematological indices, including the number of blood lymphocytes. Similarly, serum total protein and globulin were also elevated. By contrast, serum cholesterol, triglycerides and liver enzymes were lower in the experimental birds than in the control birds. Moreover, compared with the control birds, there was no significant change in the bilirubin concentration, either total or direct, and kidney-function indices in response to rutin supplementation in the experimental birds. Among the immune parameters examined, lysozyme activity, nitric oxide concentrations, and immunologlobulin M (IgM) production were significantly higher in rutin-fed birds than in the control birds; however, there was no significant effect of rutin at any concentration on the IgG and IgA concentrations and lymphoid organ weight. Of the cytokine-encoding genes studied, the genes encoding interleukin-6, nuclear-factor kappa B, and tumour-necrosis factor-α were upregulated in the spleen of the experimental birds, while the expression of interferon gamma-encoding gene was unaffected in the experimental birds. Here, rutin promoted the immune strength in birds mainly at 1 g/kg diet, suggesting that rutin is a promising feed additive for broilers.
A review of the financial impact of production diseases in poultry production systems
Authors: Jones P. J. , Niemi J. , Christensen J.-P. , Tranter R. B. , Bennett R. M.
Published: October 2018

While the academic literature widely asserts that production diseases have a significant financial impact on poultry production, these claims are rarely supported by empirical evidence. There is a risk, therefore, that the information needs of poultry producers regarding the costs associated with particular diseases are not being adequately met. A systematic literature review of poultry production diseases was undertaken, first, to scope the availability of studies that estimate the financial impacts of production diseases on poultry systems and, second, on the basis of these studies, estimates were generated of the magnitude of these impacts. Nine production diseases, selected by a panel of stakeholders as being economically important in the EU, were examined. The review found that the poultry disease literature has primarily an epidemiological focus, with very few publications providing estimates of the financial impacts of diseases. However, some publications have quantified the physical impacts of production diseases and control interventions, for example, using measures such as output volumes, mortality rates and bacterial counts. Using these data in standard financial models, partial financial analyses were possible for some poultry production diseases. Coccidiosis and clostridiosis were found to be the most common production diseases in broiler flocks, with salpingoperitonitis being the most common in layers. While the financial impact of untreated diseases varied, most uncontrolled diseases were estimated to make flocks loss-making. However, in all cases, interventions were available that signficantly reduced these losses. The review reinforces the concern that the available academic literature is not providing sufficient information for poultry producers to decide on financially optimal disease-prevention and treatment measures.
Mechanistic understanding of iron toxicity tolerance in contrasting rice varieties from Africa: 1. Morpho-physiological and biochemical responses
Authors: Onyango Dorothy A. , Entila Fredrickson , Dida Mathew M. , Ismail Abdelbagi M. , Drame Khady N.
Published: October 2018

Iron (Fe) is a fundamental element involved in various plant metabolic processes. However, when Fe uptake is excessive, it becomes toxic to the plant and disrupts cellular homeostasis. The aim of this study was to determine the physiological and biochemical mechanisms underlying tolerance to Fe toxicity in contrasting rice varieties adapted to African environments. Four varieties (CK801 and Suakoko 8 (tolerant), Supa and IR64 (sensitive)) selected from our previous work were analysed in more detail, and the first part of this study reports morphological, physiological and biochemical responses induced by Fe toxicity in these four varieties. Morphological (shoot length, root length, number of lateral roots), physiological (photosynthesis rate, stomatal conductance, transpiration rate, fluorescence, relative water content and cell membrane stability) and biochemical (tissue Fe, chlorophyll pigments, soluble sugars, protein and starch) traits were measured, as appropriate, on both shoot and root tissues and at different time points during the stress period. Fe toxicity significantly (P≤0.05) reduced growth and metabolism of all the four varieties. Tolerant varieties showed more lateral roots than the sensitive ones, under Fe toxic conditions as well as higher photosynthesis rate, chlorophyll content and cell membrane stability. Strong dilution of Fe concentration in cells was identified, as one of the additional tolerance mechanisms used by CK801, whereas Suakoko 8 mainly used strong mobilisation of carbohydrates at the early stage of the stress period to anticipate metabolite shortage. Traits associated with Fe toxicity tolerance in this study could be specifically targeted in trait-based breeding programs of superior lowland rice varieties tolerant of Fe toxicity.
Hydrogen peroxide plays an important role in PERK4-mediated abscisic acid-regulated root growth in Arabidopsis
Authors: Ma Xiaonan , Zhang Xiaoran , Yang Ling , Tang Mengmeng , Wang Kai , Wang Li , Bai Ling , Song Chunpeng
Published: October 2018

Abscisic acid (ABA) is a crucial factor that affects primary root tip growth in plants. Previous research suggests that reactive oxygen species (ROS), especially hydrogen peroxide, are important regulators of ABA signalling in root growth of Arabidopsis. PROLINE-RICH EXTENSIN-LIKE RECEPTOR KINASE 4 (PERK4) plays an important role in ABA responses. Arabidopsis perk4 mutants display attenuated sensitivity to ABA, especially in primary root growth. To gain insights into the mechanism(s) of PERK4-associated ABA inhibition of root growth, in this study we investigated the involvement of ROS in this process. Normal ROS accumulation in the primary root in response to exogenous ABA treatment was not observed in perk4 mutants. PERK4 deficiency prohibits ABA-induced expression of RESPIRATORY BURST OXIDASE HOMOLOGUE (RBOH) genes, therefore the perk4-1 mutant showed decreased production of ROS in the root. The perk4-1/rbohc double mutant displayed the same phenotype as the perk4 and rbohc single mutants in response to exogenous ABA treatment. The results suggest that PERK4-stimulated ROS accumulation during ABA-regulated primary root growth may be mediated by RBOHC.
Estimating canopy fuel characteristics for predicting crown fire potential in common forest types of the Atlantic Coastal Plain, USA
Authors: Andreu Anne G. , Blake John I. , Zarnoch Stanley J.
Published: October 2018

We computed four stand-level canopy stratum variables important for crown fire modelling – canopy cover, stand height, canopy base height and canopy bulk density – from forest inventory data. We modelled the relationship between the canopy variables and a set of common inventory parameters – site index, stem density, basal area, stand age or stand height – and number of prescribed burns. We used a logistic model to estimate canopy cover, a linear model to estimate the other canopy variables, and the information theoretic approach for model selection. Coefficients of determination across five forest groups were 0.72–0.91 for stand height, 0.36–0.83 for canopy base height, 0.39–0.80 for canopy cover, and 0.63–0.78 for canopy bulk density. We assessed crown fire potential (1) for several sets of environmental conditions in all seasons, and (2) with increasing age, density and number of prescribed burns using our modelled canopy bulk density and canopy base height variables and local weather data to populate the Crown Fire Initiation and Spread model. Results indicated that passive crown fire is possible in any season in Atlantic coastal plain pine stands with heavy surface fuel loads and active crown fire is most probable in infrequently burned, dense stands at low fuel moistures.
Why fix it if it’s not broken! The role of audiologists in families of hearing children born to deaf parents
Authors: Moroe Nomfundo
Published: October 2018

Background:

The Health Professions Council of South Africa (HPCSA) clearly states the role of audiologists in the management of children diagnosed with hearing loss. However, there are no outlined guidelines regarding the role of audiologists in hearing Children of Deaf Adults (CODAs). A literature search on the role of audiologists in this population yielded no results both locally and internationally.

Objectives:

This study seeks to understand the role of audiologists in Deaf parented families as perceived by CODAs.

Methods:

Ten CODAs aged between 21 and 40 were recruited through purposive and snowball sampling. Data were collected through qualitative, semi-structured interviews. Data were inductively analyzed through thematic analysis.

Results:

The findings revealed mixed feelings. Some participants indicated their need for audiological services while others perceived audiologists as wanting to fix something that is not broken. Furthermore, most participants indicated not needing any support services while the involvement of extended family was met with mixed feelings.

Conclusions:

There is, therefore, a need for audiologists to critically scrutinize and define their role and its boundaries in these families. This can be achieved by engaging in a frank and honest discussion between audiologists and Deaf-parented families.