Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)
Authors: Beltrán-Pavez Carolina , Gutiérrez-López Miguel , Rubio-Garrido Marina , Valadés-Alcaraz Ana , Prieto Luis , Ramos José Tomás , Jiménez De Ory Santiago , Navarro Marisa , Díez-Romero Cristina , Pulido Federico , Valencia Eulalia , Holguín África ,   The Madrid Cohort of HIV-Infected Children integrated in the Pediatric Branch of the Spanish National AIDS Network (CoRISpe),   CoRISpe Cohort Working Group, Mellado María José , Escosa Luis , García Hortelano Milagros , Sainz Talía , González-Tomé María Isabel , Rojo Pablo , Blázquez Daniel , Prieto-Tato Luis , Epalza Cristina , Ramos José Tomás , Guillén Sara , Navarro María Luisa , Saavedra Jesús , Santos Mar , Santiago Begoña , Aguilera-Alonso David , Jiménez De Ory Santiago , Carrasco Itzíar , Roa Miguel Ángel , Penín María , Martínez Jorge , Badillo Katie , Oñate Eider , Pocheville Itziar , Garrote Elisa , Colino Elena , Gómez Sirvent Jorge , Garzón Mónica , Román Vicente , Angulo Raquel , Neth Olaf , Falcón Lola , Terol Pedro , Santos Juan Luis , Moreno David , Lendínez Francisco , Peromingo Estrella , Uberos José , Ruiz Beatriz , Grande Ana , Romero Francisco José , Pérez Carlos , Lillo Miguel , Losada Begoña , Herranz Mercedes , Bustillo Matilde , Collado Pilar , Couceiro José Antonio , Vila Leticia , Calviño Consuelo , Piqueras Ana Isabel , Oltra Manuel , Gavilán César , Montesinos Elena , Dapena Marta , Álvarez Cristina , Jiménez Beatriz , Andrés Ana Gloria , Marugán Víctor , Ochoa Carlos , Alfayate Santiago , Menasalvas Ana Isabel , Ruiz Del Prado Yolanda , Soler-Palacín Pere , Frick Marie Antoinette , Mur Antonio , López Nuria , Méndez María , Mayol Lluís , Vallmanya Teresa , Calavia Olga , García Lourdes , Coll María Teresa , Pineda Valentí , Rius Neus , Dueñas Joaquín , Fortuny Clàudia , Noguera-Julián Antoni ,   Pediatric HIV-BioBank integrated in the Spanish AIDS Research Network and collaborating Centers,   CoRISpe-FARO Cohort Working Group, Bernardino Ignacio , Montes María Luisa , Valencia Eulalia , Rubio Rafael , Pulido Federico , Bisbal Otilia , Gaspar Alonso Gabriel , Berenguer Juan , Díez Cristina , Aldamiz Teresa , Montilla Pedro , Bermúdez Elena , Valerio Maricela , Sanz José , Arponen Sari , Gimeno Alejandra , Cervero Miguel , Torres Rafael , Moreno Santiago , Pérez Mª Jesús , Ryan Pablo , Troya Jesús , Sanz Jesús , Losa Juan , Gómez Rafael , Iribarren José Antonio , Rodríguez Francisco , Pascual Lydia , Aramburu María José , Goikoetxea Ane Josune , Aguirrebengoa Luis , Muñoz Josefa , Ibarra Sofía , Hernández Michele , Gómez Sirvent Juan Luis , Rodríguez Jehovana , Cárdenes Miguel Ángel , López-Cortés Luis Fernando , Roca Cristina , Llaves Silvia , Ríos María José , Rodríguez Jesús , Palomo Virginia , Pasquau Juan , García Coral , Hernández José , Martínez Clara , Rivero Antonio , Camacho Ángela , Merino Dolores , Martínez Elisa , Mateos Fernando , Blanch José Javier , Torralba Miguel , Arazo Piedad , Samperiz Gloria , Crusells María José , San Joaquín Isabel , Miralles Celia , Ocampo Antonio , Pousada Guille , Mena Álvaro , Montero Marta , Salavert Miguel , Cuéllar Sandra , Galindo María José , Ferrando Ramón , Portilla Joaquín , Portilla Irene , Gutiérrez Félix , Masiá Mar , Robledano Cati , Adsuar Araceli , Hinojosa Carmen , Bachiller Pablo , Abadía Jésica , Mostaza José Luis , Pérez Rosario , Galera Carlos , Albendín Helena , Pérez Aurora , Blanco José Ramón , Burgos Joaquín , Torres Berta , Lazzari Elisa 
Published: October 2020

The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures.