bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria
Authors: Akase Iorhen Ephraim , Akintan Patricia Eyanya , Otrofanowei Erereoghor , Olopade Oluwarotimi Bolaji , Olorunfemi Gbenga , Opawoye Adefolarin , Alakaloko Felix M. , Ima-Edomwonyi Uyiekpen Emmanuel , Akinbolagbe Yeside Olubunmi , Agabi Osigwe Paul , Nmadu Danladi Abraham , Akinbode Gbemileke O. , Olasope Aramide C. , Ogundare Adewale , Bolarinwa Abiola Bukunmi , Awojumobi-Otokiti Oluwakemi Elizabeth , Enajeroh Precious J. , Karami Moses , Esezobor Christopher Imokhuede , Oshodi Yewande O. , Ayotunde Oluwole Ayodeji , Adeyemo Wasiu Lanre , Bode Christopher O.
Published: May 2024

Introduction:

Clinical data on the differences in presentation and outcome of admitted COVID-19 patients in Nigeria are limited. This study aimed to compare the first and second waves of the COVID-19 pandemic in a Tertiary Hospital in Lagos and describe the clinical differences between the waves, the severity of COVID-19, and the mortality differences.

Methods:

The study was a retrospective review of the medical records of all children and adults admitted to the Lagos University Teaching Hospital (LUTH) COVID-19 Isolation and Treatment Centre during the first wave (from April 2020 to October 2020) and second wave (from December 2020 to April 2021). The clinical characteristics (including COVID severity) and outcome among admitted patients during the two waves were compared.

Results:

Between April 2020 and April 2021, 602 patients were admitted to LUTH for COVID-19. Patients in the first wave were significantly younger (43 vs. 54.5 years), more in number (53.8% vs. 46.2%), and had a higher proportion of health-care workers than those in the second wave (14.5% vs. 6.5%). Comorbidities were present in more than half of the patients hospitalized for COVID-19 infection (51.0%). This proportion was much higher during the pandemic's second wave (41.7% vs. 61.9%, P < 0.001). The most common comorbidity found in hospitalized patients was hypertension (37.0%). Patients admitted during the second wave had shorter stays (11 vs. 7 days) and similar mortality rates (10.2% vs. 10.8%).

Conclusion:

The first and second waves had comparable mortality rates though patients in the first wave were younger and there were more healthcare providers in the cohort. Patients admitted to the second wave however had more comorbidities but shorter lengths of stay which may suggest a better understanding of the infection and better outcome.
Extreme Delta Brush Electroencephalography Pattern in Anti-yo Encephalitis: A Case Report
Authors: Xiao Fu-Yao , Liu Yi , Lin Yu-Kai , Tsai Chia-Kuang
Published: May 2024

Autoimmune encephalitis is complex and gradually being recognized. Anti-N-methyl-D-aspartate Receptor (Anti-NMDAR) encephalitis was the most well-known and its unique electroencephalography (EEG) pattern is extreme delta brush (EDB). Anti-Yo encephalitits is far less than common anti-NMDAR encephalitis (anti-NMDARE). A 78-year-old male presented with progressive apathy, hypotension, unsteady gait, and depressed consciousness. EEG revealed an EDB pattern while the serum test was positive for anti-Yo antibodies. The patient then received 10 rounds of plasma exchange, and his blood pressure stability improved. Consequently, urine cytology and abdominal computed tomography revealed atypical cells and linear enhancement in the bladder dome, respectively. However, instead of further pathological confirmation and treatment, the patient’s family requested hospice care. As a result, the patient died of desaturation 7 days later after the withdrawal of ventilatory support. First recognized in 2012, EDB is believed to be specific to NMDARE. However, to date, EDB has not been well described, and no description is available regarding its reactivity. To our knowledge, this is the first case of EDB with anti-Yo encephalitis. Similar to the cases of EDB with anti-NMDARE, our patient did not have satisfied prognosis despite no further investigation and treatment of the possible underlying malignancy. As the prevalence and underlying mechanism of this EEG pattern are unclear, further studies are warranted to identify the potentially similar mechanisms and correlation between anti-NMDAR and anti-Yo encephalitis.
Tongue Abnormalities in Children: Case Series and Review of Literature
Authors: Kakran Anisha , Singhal Ruchi , Namdev Ritu , Kaushik Himani , Negi Shefali , Dayma Charu
Published: May 2024

Our oral cavity reflects the inside of our body, i.e., a healthy mouth is directly associated with healthy body. Tongue is a muscular organ present in the floor of the oral cavity; involved in speech, chewing, carrying taste sensations, and deglutition. Tongue also plays a major role in identifying and diagnosing underlying systemic diseases. Therefore, a complete information regarding the examination, diagnosis, and management of tongue abnormalities become important. Tongue abnormalities can be seen at any age and therefore classified as developmental and acquired (inflammatory, infective, traumatic, environmental, autoimmune, and benign and malignant tumors). However, some common abnormalities of tongue in the case of children have not been described in literature yet. Hence, the present review will focus on the abnormities of tongue and their management in children along with presentation of some of the cases reported to the department.
Management of Oral Health Complications Associated with Smokeless Tobacco
Authors: Vinod V.C. , Baviskar Roza Rajkumar
Published: May 2024

This case report highlights the management of oral health complications related to smokeless tobacco use. A 38-year-old male patient presented with decayed teeth and oral mucosal changes resulting from smokeless tobacco consumption. After receiving habit cessation counseling, the patient reported for follow-up. This report discusses the importance of habit cessation counseling and demonstrates how this case contributes to the broader understanding of managing oral health complications associated with smokeless tobacco. It emphasizes the need for tobacco cessation and improved oral hygiene practices in preventing and managing these complications.
Notable Resources for Assistance in the Research and Scholarly Publication Journey
Authors: Dharmshaktu Ganesh Singh , Pangtey Tanuja
Published: May 2024

Research journey is an arduous process for beginners, but consistent learning and efforts make one better every time. Regular study of core principles of research and publication process coupled with persistent writing and submission is key to gaining experience and planning robust studies later. While the guidance of seniors or seasoned researchers is important asset, but the absence of it should not dampen enthusiasm. Various educational resources exist to serve the purpose of continuous professional development and improve knowledge regarding scholarly publication. A self-directed learning is also of paramount importance, and various educational contents are available on the Internet worth a visit. Recent trends in the world of scholarly publication are a perennial process and adherence to stringent research practices is a key element of a study well done. A general review of a few common resources which may help increase our knowledge regarding research process, are described here for the educational purpose of postgraduate students and for revision purposes for experienced researchers.
CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system
Authors: Yin Lin , Xu Yalan , Mu Jie , Leng Yu , Ma Lei , Zheng Yu , Li Ruizhi , Wang Yin , Li Peifeng , Zhu Hai , Wang Dong , Li Jing
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202508000-00031/figure1/v/2024-09-30T120553Z/r/image-tiff

The protein connector enhancer of kinase suppressor of Ras 2 (CNKSR2), present in both the postsynaptic density and cytoplasm of neurons, is a scaffolding protein with several protein-binding domains. Variants of the CNKSR2 gene have been implicated in neurodevelopmental disorders, particularly intellectual disability, although the precise mechanism involved has not yet been fully understood. Research has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane, thereby influencing synaptic signaling and the morphogenesis of dendritic spines. However, the function of CNKSR2 in the cytoplasm remains to be elucidated. In this study, we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of CNKSR2. Through a combination of bioinformatic analysis and cytological experiments, we found that the CNKSR2 interactors were significantly enriched in the proteome of the centrosome. We also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker CEP290. Subsequent colocalization analysis confirmed the centrosomal localization of CNKSR2. When we downregulated CNKSR2 expression in mouse neuroblastoma cells (Neuro 2A), we observed significant changes in the expression of numerous centrosomal genes. This manipulation also affected centrosome-related functions, including cell size and shape, cell proliferation, and motility. Furthermore, we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum disorder. Our findings establish a connection between CNKSR2 and the centrosome, and offer new insights into the underlying mechanisms of neurodevelopmental disorders.
On some convexity questions of Handelman
Authors: Simanek Brian
Published: May 2024

We resolve some questions posed by Handelman in 1996 concerning log convex
$L^1$
functions. In particular, we give a negative answer to a question he posed concerning the integrability of
$h^2(x)/h(2x)$
when h is
$L^1$
and log convex and
$h(n)^{1/n}\rightarrow 1$
.
Spectral metric and Einstein functionals for the Hodge–Dirac operator
Authors: Dąbrowski Ludwik , Sitarz Andrzej , Zalecki Paweł
Published: May 2024

We examine the metric and Einstein bilinear functionals of differential forms introduced by Dąbrowski et al. (2023), for the Hodge–Dirac operator

d+\delta

on an oriented, closed, even-dimensional Riemannian manifold. We show that they are equal (up to a numerical factor) to these functionals for the canonical Dirac operator on a spin manifold. Furthermore, we demonstrate that the spectral triple for the Hodge–Dirac operator is spectrally closed, which implies that it is torsion-free.
The bundling of claims in cartel damages litigation in Germany, the Netherlands, the United Kingdom, Italy and France
Authors: Bousie Hans , Barennes Marc , Bossen Tessel , Scoccini Giovanni , Seifert Konstantin
Published: May 2024

When pursuing damages in so-called ‘follow-on’ cartel damages claims claimants can anticipate fierce resistance from defendants. Normally, the only way for claimants to survive this legal battle is to combine forces. This is what is called the bundling of claims. This article contains a comparative study of the possibility of those harmed by cartels and other anti-competitive conduct working together as claimants by bundling their individual claims in various European jurisdictions: Germany, the Netherlands, the UK, Italy and France.
Choosing the right filter: Market definition in two-sided markets
Authors: Ralston Helen , Leslie Will , O'Reilly Eoin , Masters Robin , Heinen Victoria
Published: May 2024

The advent of the digital economy over the last two decades has stimulated significant regulatory change. While much ink has been spilled over high-profile enforcement and potential competition policy reform, the Commission’s review of its market definition notice has passed relatively unnoticed. But the review has the potential to frame how competition law assesses digital markets—as well as every other type of market—for decades. It offers the opportunity to
address some of the new questions posed by digital platforms, in a consistent way across the EU. This article offers thoughts on the thorny issue of how market definition should apply to platform markets, the relevance of the SSNIP test, and some practical perspectives on the vexed topic of defining one or more markets for two-sided platforms.
Mathematics teachers in the time of digital technologies: a theoretical framework adapting the double approach to study their activity
Authors: Abboud Maha
Published: May 2024

Article à paraître dans un numéro spécial de la revue Recherches en Didactique des Mathématiques

This text deals with the mathematics teacher’s activity in digital technologies-based sessions. It is composed of two parts. The first part outlines recent studies and theoretical models that have been developed to study the teaching dimension in learning and teaching within environments integrating these technologies. The second presents a theoretical framework for the study of the teacher's activity in ordinary classroom situations: the DAaT (Double Approach applied to Technology). This framework is derived from the Double Didactic and Ergonomic Approach (Robert and Rogalski, 2002) while introducing adaptations and adding complementary constructs in order to better consider the specificity of the studied environments. The theoretical concepts thus developed are presented and discussed. The conclusion returns to the usefulness of the theoretical and methodological tools provided by the research in this field for the enrichment of teacher practices or for teacher education

Ce texte porte sur l’activité de l'enseignant de mathématiques utilisant des technologies numériques. Il est composé de deux parties. La première esquisse un panorama des études récentes et des modèles théoriques qui ont été développés pour étudier la dimension enseignante dans des environnements d’apprentissage et d’enseignement intégrant ces technologies. La deuxième présente un cadre théorique pour l’étude de l’activité de l’enseignant dans des situations ordinaires de classe : la DAaT (Double Approche adaptée aux Technologies). Ce cadre prend appui sur la Double Approche didactique et ergonomique des pratiques (Robert et Rogalski, 2002) tout en y introduisant des adaptations et y apportant des compléments et des prolongements afin de rendre compte de la spécificité des environnements étudiés. Les concepts théoriques ainsi développés sont présentés et discutés. La conclusion revient sur l’utilité des outils et résultats issus de la recherche dans ce domaine pour l’enrichissement des pratiques ou pour leur formation
Pencegahan Kejahatan Siber Terkait Distribusi Perjudian Online di Indonesia dalam Rangka Mewujudkan Keamanan dan Ketertiban Masyarakat
Authors: Hendarto Daniel Hasianto , Handayani Riska Sri
Published: May 2024

This research aims to explore policing strategies in the prevention of online gambling crimes. The focus of this paper is to identify the characteristics and development of online gambling crimes, the factors that contribute to the implementation of the crime prevention strategy at the Directorate of Cyber Crime of the Criminal Investigation Unit of the National Police, and the ideal policing strategy in preventing such crimes. The theoretical perspectives used in this research are Sittuational Crime Prevention theory and Partnership Theory. The results of this study explain that in efforts to prevent online gambling crimes, development is needed related to various strategies and approaches in preventing these crimes, this is because the development of online gambling that has occurred today cannot be matched by crime prevention efforts carried out by the Police and related Government Institutions.
Cercariae from snails in rice fields and canal supplying water directly to Trichopodus microlepis fish cultured in earthen ponds in Binh Chanh district, Ho Chi Minh City, Vietnam.
Authors: Thien Pham C. , Manh Ho T. , Quyen Duong T. , Xuan Nguyen T.L. , Lan Nguyen T. , Hung Nguyen M.
Published: May 2024

Snails are the first intermediate host in the life cycle of trematodes. Previous research found that Trichopodus microlepis fish, cultured in earthen ponds in Tan Nhut Commune, Binh Chanh District, Ho Chi Minh City, Vietnam had a high infection rate with metacercariae of Centrocestus formosanus and Procevorum sp. It is necessary to investigate whether habitats supplying water to the ponds may contribute to the transmission by carrying intermediate hosts and/or cercariae into these ponds or not. A study of cercariae and snail composition in rice fields and canal supplying water directly to these Trichopodus microlepis ponds was carried out with six samplings in the years 2022 and 2023. A total of 1,151 snails were collected, and nine snail species belonging to 8 genera and 6 families were identified. Three snail species in both rice fields and canal were infected with trematode (cercariae stage) including Bithynia siamensis, Lymnaea viridis and Indoplanorbis exustus. The overall prevalence in the dry season (25.9%) was significantly higher than in the wet season (10.6%) (P<0.05). Three cercariae morphotypes were recovered from snails: xiphidio (in all three snails), echinostome (in Lymnaea viridis and Indoplanorbis exustus), and pleurolophocercous in Bithynia siamensis. This finding shows that Bithynia siamensis is one of the infected sources for Trichopodus microlepis fish cultured in ponds, as pleurolophocercous is also the cercariae in the family of Heterophyidae (including Centrocestus formosanus and Procevorum sp.). Further research should be done to clarify the transmission of fish-borne zoonotic diseases to cultured Trichopodus microlepis in other habitats including the actual fishponds, and sources of trematodes in order to produce Trichopodus microlepis free of metacercariae, contributing to clean aquaculture development and safe food for local people in the area.
Risk Assessment of Neobank in Indonesia: Case Study of Bank Gembira Indonesia
Authors:   School of Business and Management, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, Indonesia, Cecilia Ghina , Sudrajad Oktofa Yudha ,   School of Business and Management, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, Indonesia
Published: May 2024

This research delves into a comprehensive analysis of the risks encountered by Bank Gembira, a notable neobank in Indonesia. Through combining qualitative and quantitative methodologies, this research study identifies and classifies various types of risk, including credit risk, market risk, liquidity risk, and operational risk. In facilitating the prioritization process, the study makes use of Saaty’s Analytic Hierarchy Process (AHP) as instrument. The study highlights the importance of understanding customer behavior in mitigating risks for neobanks and recommends further research on risk assessment in the neobanking sector. The analysis emphasizes the critical role of credit risk and operational risk for Bank Gembira as a neobank. Through AHP calculations, credit default and cyberattacks are identified as the highest priority risks, underscoring the need for robust risk treatment plans to address these high-level risks effectively. Recommendations are proposed to address these risks, such as enhancing credit scoring for P2P lending partners, improving cybersecurity measures, collaborating with regulators, tracking technology updates, partnering with e-commerce platforms, offering promotional programs, developing digital talent programs, and attracting MSMEs customers. Further research on risk assessment in the neobanking sector is suggested to enhance risk management practices and ensure sustainable growth for neobanks like Bank Gembira.
Interpretation of the Lyrics of Teary Eyed Tears by Rubah Di Selatan (OST. PORTRAIT OF CANAL YUSHIRO): A Study of Riffaterre's Semiotics
Authors:   Java Language Education Study Program Graduate Program Faculty of Languages, Arts and Culture Yogyakarta State University Jl. Colombo Yogyakarta No. 1, Sleman, Daerah Istimewa Yogyakarta 55281, Indonesia, Zamzami Nur Ahmad , Widyastuti Sri Harti ,   Java Language Education Study Program Graduate Program Faculty of Languages, Arts and Culture Yogyakarta State University Jl. Colombo Yogyakarta No. 1, Sleman, Daerah Istimewa Yogyakarta 55281, Indonesia
Published: May 2024

The aims of this study is to describe the heuristic and hermeunitic interpretations, matrices and models, hypograms, and indirectness of expression contained in the lyrics of "Teary Eyed Tears" by Rubah Di Selatan, which is the original soundtrack of the independent film Portrait Canal Yoshiro. This investigation employs a descriptive method. Using Riffaterre's semiotic theory, the results demonstrate a) heuristic and hermeunitic readings, b) matrices and models, c) actual and potential hypograms, and 4) the indirectness of expression in the lyrics of the song "Teary Eyed Tears" by Rubah Di Selatan, which is the original soundtrack in the independent film Yushiro Canal Portrait.
Inclusão da Classificação Internacional de Funcionalidade, Incapacidade e Saúde nos projetos pedagógicos de cursos de graduação em Fisioterapia e Terapia Ocupacional de Universidades Federais Brasileiras
Authors: De Oliveira Huryel Tarcio , Rodrigues Gleyson Hiego Vieira , Rocha Tainara Davidis , Fangel Renan , Fangel Leticia Meda Vendrusculo
Published: May 2024

Introdução: A Fisioterapia e a Terapia Ocupacional têm um olhar voltado para a funcionalidade do indivíduo na sua prática profissional. A funcionalidade e a incapacidade são descritas pela Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF), que deve ser utilizada interdisciplinarmente. O uso da CIF por fisioterapeutas e terapeutas ocupacionais é garantido por legislações brasileiras, que também recomendam às Instituições de Ensino Superior o ensino da CIF nos cursos de graduação, pós-graduação e extensão em Fisioterapia e Terapia Ocupacional. Objetivo: Identificar a inserção da CIF nos projetos pedagógicos (PPCs) dos cursos de fisioterapia e terapia ocupacional de Universidades Federais brasileiras. Método: Pesquisa documental e exploratória      dividida em duas etapas, sendo elas identificação dos cursos e extração de dados dos PPCs.  Resultados: Foram analisados 39 PPCs considerando os dois cursos. 22 PPCs incluíram o termo funcionalidade ou a CIF em ao menos 1 dos três tópicos analisados, o correspondente a cerca de 56% dos PPCs incluídos neste estudo. Conclusão: A CIF ainda é pouco inserida nos PPCs dos cursos de Fisioterapia (66%) e de Terapia Ocupacional (50%) de Universidades Federais brasileiras, fazendo-se necessária a inserção desse componente curricular para formar profissionais com um olhar abrangente em relação à saúde da população, e além disso, se adequarem às novas proposições de Diretrizes Curriculares Nacionais. É preciso também que pesquisadores estudem e aprofundem suas análises acerca do modelo biopsicossocial, para que assim possam propor métodos de suprimento ao déficit de conhecimento atual sobre a CIF por terapeutas ocupacionais e fisioterapeutas.
Vivência acadêmica e saúde mental de estudantes de Terapia Ocupacional
Authors: Neto de Menezes Camargo Campos Roberta Liz , Oliveira Adrielly Pereira , Matsukura Thelma Simões , Constantinidis Teresinha Cid
Published: May 2024

Introdução: A saúde mental de estudantes universitários tem sido alvo de preocupação social em decorrência da elevada prevalência de transtornos mentais entre este grupo. Além de alto índice de reprovação, trancamento e evasão universitária, verifica-se estresse, ansiedade, depressão, drogadição, suicídio entre esses jovens. Objetivo: compreender a vivência acadêmica de estudantes de terapia ocupacional e identificar conteúdos e práticas do curso que afetam a saúde mental, na perspectiva dos estudantes do curso. Método: participaram 25 estudantes de diferentes universidades e períodos do curso de terapia ocupacional. Foram realizadas sessões de grupo focal, que foram transcritas e analisadas por meio do software IRAMUTEQ (Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires). Resultado: foi identificado que o sofrimento psíquico vivenciado por esse grupo está relacionado à densidade de conteúdo nas disciplinas, às especificidades da formação, às horas de estudos demandadas pelo curso, à preocupação com os direitos dos sujeitos assistidos e destacam a sensação de invisibilidade experimentada ao se identificar como estudante de terapia ocupacional. Os docentes do curso se apresentam solícitos para a escuta e acolhida das demandas dos estudantes, realizadas informalmente Conclusão: Ao abordar tal tema com estudantes de terapia ocupacional, cuja caracterização mostra -se próxima, comum, ao grupo ampliado de estudantes universitários, o presente estudo colabora com os estudos e ações de saúde mental de acadêmicos de outros cursos e com seus formadores.
 Palavras-chave: Estudantes. Saúde Mental. Terapia Ocupacional
Cuidados paliativos e Doença de Alzheimer: análise bibliométrica e de conteúdo na Biblioteca Virtual em Saúde
Authors: De Oliveira Henrique Gabriela , Rebellato Carolina
Published: May 2024

Introdução: A Doença de Alzheimer se configura como um problema de saúde pública. Apesar dos avanços quanto à literatura científica e políticas públicas, há falta de reconhecimento da elegibilidade dos cuidados paliativos para pessoas com demência e de capacitação profissional, além de acesso a serviços especializados. Objetivo: Mapear o cenário da produção científica nacional e internacional acerca dos cuidados paliativos destinados às pessoas com Doença de Alzheimer. Método: A pesquisa bibliográfica, exploratória-descritiva realizada por meio de análise bibliométrica e de conteúdo, analisou 17 artigos disponíveis na Biblioteca Virtual de Saúde. Resultados e Discussão: Os artigos foram publicados em 13 periódicos, com a participação de 63 autores de diferentes países. A amostra dos estudos primários foi composta por pessoas com demência internadas, residentes em diferentes tipos de instituições e em domicílio, familiares e profissionais, sobretudo médicos e enfermeiros, com o objetivo principal de avaliar a qualidade dos cuidados oferecidos, acesso a serviços e associação entre sintomas e qualidade de vida nas últimas semanas de vida. Foi possível extrair duas temáticas pela análise dos objetivos e desfechos: 1) intervenções terapêuticas e recursos e 2) instrução de profissionais e familiares envolvidos no cuidado. Conclusão: Verifica-se a necessidade de investir na capacitação profissional na área, ampliação de pesquisas sobre intervenções não farmacológicas e suporte aos familiares/cuidadores, além de acabar com a percepção errônea de cuidados paliativos como sinônimo de cuidados de fim de vida.
Percursos formativos no contexto da implementação do novo Ensino Médio no Amazonas:
Authors: Castro Juliana Mota de , Caldas Rafaela Silva Marinho , Falcão Nádia Maciel
Published: May 2024

O trabalho analisa como a escolha dos Itinerários Formativos é abordada nos documentos que orientam a implementação do Novo Ensino Médio no Amazonas (NEM-AM). As alterações impostas para o ensino médio são abordadas neste estudo a partir de perspectiva crítica que as compreendem como negação ao direito à educação básica dos jovens estudantes do ensino médio público. Consiste em pesquisa documental, de natureza qualitativa, e utiliza técnicas da análise de conteúdo para analisar três documentos que direcionam a implementação do NEM-AM, a saber, o Referencial Curricular Amazonense do Ensino Médio, a Proposta Curricular e Pedagógica do Ensino Médio e o Documento Orientador Implementação do Novo Ensino Médio. Os resultados apontam que diferente do que se anuncia no campo conceitual dos documentos, o âmbito operacional demonstra que, dadas as condições materiais das escolas públicas, as suposições de um ensino médio que atenda aos interesses e expectativas das diferentes juventudes no contexto amazônico, não se sustentam. Sob a propagada liberdade de escolha dos jovens, a reforma no ensino médio público, atende aos interesses privatistas, precariza a profissão docente, nega o direito à formação humana de caráter mais abrangente e acentua as desigualdades sociais.
A política educacional como produto e como produtora de novos mercados:
Authors: Faria Camila Grassi Mendes
Published: May 2024

O objetivo dessa pesquisa é analisar o papel atribuído ao Movimento Pela Base Nacional Comum (MPBNC) na produção de valores, técnicas e normas que vêm compondo o atual modelo de governança da política educacional brasileira, assim como mapear os possíveis elementos de privatização da política e da educação básica que têm sido ampliados a partir da atuação de seus agentes e instituições na produção e implementação da Reforma do Ensino Médio. O estudo toma como corpus de análise os documentos disponíveis na página oficial do MPBNC publicados entre 2013 a junho de 2020, assim como as normatizações oficiais produzidas via Conselho Nacional de Educação e Ministério da Educação no período de 2016 a 2018, ligadas a regulamentação dos programas-piloto de implementação da Reforma do Ensino Médio e da Base Nacional Comum Curricular (BNCC). A metodologia utilizada para a análise de documentos de políticas tomou como base o aporte teórico desenvolvido por Shiroma; Campos; Garcia; Cardoso (2005). Conclui que o MPBNC, enquanto rede política de governança brasileira, vem atuando no avanço de diferentes tipificações de privatização da política educacional. Entre elas, se destaca a atuação direta, por meio de seus agentes, na formulação de políticas educacionais e a realizações de assistências na implementação dessas mesmas políticas. Esse fenômeno vem fortalecendo a divulgação de soluções educacionais que tem como objetivo mitigar os problemas de implementação gerados pela reforma curricular da educação básica brasileira.
REAL-TIME MONITORING FOR DETECTING LAKE POLLUTION AND BIOTIC CONSERVATION
Authors: Dr. Shalini S  , Sree K Mounika , Prajwal M H  , Nitin Reddy N V  , P Govardhan Reddy
Published: May 2024

This research unveils a comprehensive system designed to tackle plastic pollution in lakes autonomously, eliminating the necessity for human intervention. By harnessing sensor data and camera imagery processed through the YOLO algorithm, the system identifies plastic debris. It then calculates the debris density and compares it against a preset threshold. Once the threshold is exceeded, an automated email alert containing the density data is sent to relevant authorities. Additionally, water quality sensors are integrated to continuously monitor environmental conditions. Regular updates are provided to enable proactive measures in pollution prevention. This endeavor showcases the utilization of advanced technology to address environmental challenges and safeguard aquatic ecosystems' health. By employing automated detection and monitoring mechanisms, the system offers a sustainable  approach to combat plastic pollution in lakes, fostering environmental conservation endeavors.
Integrated Bioinformatics Analysis Reveals ceRNA Triplet Related to Apoptosis in Gastric Cancer
Authors: Nath Anju R. , Natarajan Jeyakumar
Published: May 2024

Apoptosis is a form of programmed cell death and evading the apoptosis is a milestone in gastric cancer (GC) tumorigenesis. Various RNAs such as miRNA (microRNA), mRNA (messenger RNA), lncRNA (long non-coding RNA), circRNA (circular RNA), play crucial roles in the apoptosis mechanism. In this present study, we aimed to understand the role played by these RNAs in apoptosis in GC. We constructed a ceRNA (competitive endogenous RNA) network using the expression profiles obtained from SRA (Sequence Read Archive) and GEO (Gene Expression Omnibus) datasets. After network construction, the differentially expressed mRNAs were used for gene prioritization. The prioritized genes and the RNAs interacting with them were analyzed to study their role in GC apoptosis. Then, we performed functional and pathway analysis to understand the role played by these genes in gastric cancer. This resulted in 37 miRNA-mRNA interactions, one miRNA-lncRNA interaction, and 17 miRNA-circRNA interactions. The binding site analysis resulted in 10 miRNAs that share common MRE (miRNA Response Elements) among mRNA, lncRNAs, circRNA. Besides, we found 33 miRNA-mRNA-circRNA and two miRNA-mRNA-lncRNA valid interactions. Integration of multiple omics datasets revealed dysregulated genes, including IGF1, MME, CCND2, CDH2, and COL1A1, implicated in GC apoptosis. Functional enrichment analysis highlighted pathways related to apoptosis, with CCND2 emerging as a key player. The integrative methodology has revealed a new potential diagnostic biomarker for the regulation of gastric cancer (GC) apoptosis: the CCND2-miR-141-3p-hsa_circ_0008035 ceRNA triplet. This discovery offers fresh perspectives into the intricate regulatory pathways governing gene expression in GC, promising significant insights into its pathology.
 
Received: 6 January 2024 | Revised: 25 April 2024 | Accepted: 10 May 2024
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
The data that support the findings of this study are openly available in NCBI database at https://www.ncbi.nlm.nih.gov/sra; in Gene Expression Omnibus (GEO) at https://www.ncbi.nlm.nih.gov/geo/; in ENCORI from https://academic.oup.com/nar/article/42/D1/D92/1063720?login=false.
 
Author Contribution Statement
Anju R. Nath: Conceptualization, Methodology, Data Curation, Writing – original draft, Visualization. Jeyakumar Natarajan: Writing – review & editing, Supervision.
Uplifting Brand Equity to Unprecedented levels by Introducing Purpose as the New 8th 'P' in the Marketing Mix
Authors: Arvind Mallik D. M. , Aithal P. S.
Published: May 2024

Background: In the wake of the COVID-19 pandemic, businesses are compelled to reassess their branding strategies to thrive in the digital landscape. This abstract introduces the concept of Purposeful Branding, proposing the integration of "Purpose" as the 8th element in the marketing mix. This addition aims to bolster brand equity within management institutions, leveraging technological integration to navigate the digital evolution effectively.
Objectives: The primary objective is to explore the integration of Purpose into the marketing mix, emphasizing its role in fostering deeper connections with stakeholders and driving sustainable growth. The abstract seeks to advocate for genuine dedication from companies to align their practices with professed values, thereby enhancing brand equity in the digital era.
Design/Methodology: The research employs a qualitative approach, drawing from various case studies and industry insights to illustrate the implementation and impact of Purposeful Branding. It examines how organizations strategically position themselves amidst the evolving digital landscape, emphasizing authenticity and transparency in executing Purpose-driven marketing strategies.
Findings: The findings underscore the significance of Purposeful Branding in generating substantial value for businesses. Authentic alignment with professed values cultivates stronger bonds with consumers, employees, and society at large. The abstract highlights the potential of Purpose-driven marketing mix to fortify brand equity and adapt to the dynamic demands of the digital era.
Results: The integration of Purpose into the marketing mix yields tangible results for organizations, including enhanced brand loyalty, improved reputation, and increased competitive advantage. By harnessing the power of Purposeful Branding, companies can foster meaningful relationships with stakeholders, driving sustainable growth in the digital realm.
Implications: The implications of Purposeful Branding extend beyond immediate financial gains, encompassing broader societal impact and long-term sustainability. This abstract advocates for a comprehensive exploration of Purpose-driven marketing strategies, emphasizing their role in addressing contemporary challenges and advancing organizational objectives in the digital era.
Type of Paper: Conceptual Research.
Estrategias comunicacionales para promover acciones saludables y ambientalmente sostenibles en comunidades rurales del corregimiento de Sorá, distrito de Chame
Authors: Vásquez García Magdala Indira , Acevedo Domínguez Carolina Efigenia , Castrellón Miranda Diznarda Gloricelda
Published: May 2024

Con el objetivo de desarrollar una campaña publicitaria para promover buenas prácticas de salud y cuidado del ambiente en las comunidades rurales y semirurales del corregimiento de Sorá, se realizò una investigación para determinar los medios de comunicación utilizados por la población para mantenerse informada, lo cual proporciona datos relevantes para definir una estrategia de medios adecuada a la realidad de la región
Resultados del componente Comunicación, estudio multidisciplinario que unió diversas disciplinas en la Universidad de Panamá y que vinculó los diferentes ODS con una mirada compleja y permitió la incorporación de indicadores socioambientales y socioculturales logrando una retroalimentación precisa en beneficio de las comunidades estudiadas.
La investigación se basó en un diseño cuasi experimental, dividido en cinco fases: reconocimiento y acercamiento directo, investigación, implementación, seguimiento y monitoreo de estrategias educativas y de comunicación publicitaria, resultados, impacto y limitación del proyecto y cierre del proyecto.
Los resultados demostraron que la televisión sigue siendo un medio de gran penetración al momento de informarse, seguida de las redes sociales y, por último, la radio. Por consiguiente, los medios digitales son una buena opción de comunicación en las comunidades rurales, tanto por su inmediatez como por su bajo costo
Se desarrolló una campaña publicitaria bajo el concepto “Somos uno” y eslogan “tus acciones importan”, que permitió la intervención desde diversas perspectivas y abordar la complejidad de situaciones que acontecen en las comunidades, orientadas a mejorar la calidad de vida por medio de estrategias de comunicación, enseñanza y aprendizaje con una visión integradora.
Kubrick
Authors: Kolker Robert P. , Abrams Nathan
Published: May 2024

The enigmatic and elusive filmmaker Stanley Kubrick has not been treated to a full-length biography in over twenty years. Stanley Kubrick: An Odyssey fills that gap. It is based on access to the latest research, especially into his archive at the University of the Arts, London, and other papers as well as new interviews with family members and those who worked with him. It offers comprehensive and in-depth coverage of Kubrick's personal, private, public, and working life. We discuss not only the making of his films, but also about those he wanted but failed to make like Burning Secret, Napoleon, Aryan Papers, and A.I. We discover what he was doing when he was not making films. This biography will puncture a few myths about this allegedly reclusive filmmaker, who created some of the most important works of art of the twentieth century.
SPLIGN: Smart-belt Posture Monitoring System Based on AI-algorithms for Sitting Persons
Authors: Tlili Ferdews , Haddad Rim , Bouallegue Ridha
Published: May 2024

The back pain is the main common health problems on this decade because of the sitting for a long time tilted on the computer for working, studying or playing. The back problems are widely spread for different ages from young to old people. Last medical research demonstrates that sitting with the posture align can prevent and remedy many spine problems. In this paper, we propose ’SPLIGN’ which a posture monitoring system designed to help maintaining the good posture during sitting. The SPLIGN is a smart belt equipped with inertial sensors. A mobile and web applications are developed for monitoring and remind the user to correct posture. The proposed system is based on a detailed study of the machine learning algorithms in order to choose the best accurate algorithm for posture prediction. The main studied algorithms are Convolutional neural network (CNN), The K-nearest Neighbors (KNN), Support-vector machines (SVM), Decision tree classification, Random forest, Naive Bayes Classifier and Boosting algorithm. The test results demonstrate that The Random Forest algorithm has the best accuracy 99.67% compared to the other algorithms with appropriate processing time 67.7 ms for real time posture monitoring system.
Cooking Energy Systems and their Effect on Environmental Sustainability in Dodoma, Tanzania: A Driver-Pressure-State-Impact-Response (DPSIR) Synthesis
Authors: Ndunguru Editha M.
Published: May 2024

Consumption of energy for various uses including cooking, has various effects on the welfare of the environment. In developing countries where the majority rely on traditional biomass, cooking energy systems entail multiple disruptions to environmental sustainability. The objective of this paper is to integrate the prevailing cooking energy use systems of Dodoma region and environmental sustainability. The study uses the Driver-Pressure-State-Impact-Response (DPSIR) framework to synthesize the two circumstances. Two sites, one rural and one urban were selected for data collection. The study adopted a case study design. Mixed methods were used to gather and analyze the data. Probability and non-probability sampling techniques were employed in the selection of the respondents. The target population was the households. The sample size constitutes 210 households. Methods of data collection included survey, in-depth interview, focus group discussion and non-participant observation. Semi structure questionnaires, interview guides and focus group discussion Results reveal a significant proportion of the population (72.4%) using biomass energy for cooking. Disaggregated data expose the rural setting to have relatively higher proportions (89. %) as opposed to the urban (53.1%). The study further noted that persistent use of biomass energy is influenced by availability, accessibility, and affordability. Moreover, many households have been using inefficient stoves which lead to the consumption of large quantities of energy. A transition from firewood to charcoal in the rural area, and a thriving charcoal business in the urban have contributed to the clearance of forests and chopping off huge trees in the rural (the source area). These have led to the gradual disappearance of certain tree species. The study found no deliberate efforts at the individual or community level to restore environmental sustainability despite all the alarming indicators. Even though there are institutional frameworks, it was very hard to establish the duties and responsibilities of the institutions regarding the responses. The study concludes that there is a long way to go before biomass energy is abandoned, therefore individuals, communities and the government to take action to safeguard the environment for the benefit of the current and future generations.
A SOBREPOSIÇÃO DE DIREITOS FUNDAMENTAIS EM CONFLITO: A DICOTOMIA ENTRE O DIREITO À VIDA E A LIBERDADE RELIGIOSA NO CONTEXTO DA TRANSFUSÃO DE SANGUE AOS SEGUIDORES DA TESTEMUNHA DE JEOVÁ
Authors: Fernandes Lorrayna Lima , Oliveira Rômulo de Morais e
Published: May 2024

Esta pesquisa partiu do tema envolvendo o conflito entre o direito fundamental à vida e a liberdade religiosa no âmbito da transfusão de sangue para pessoas pertencentes da testemunha de Jeová. Utilizou-se como fonte de pesquisa doutrinas e jurisprudenciais, buscando compreender qual o direito constitucional vai se sobrepor diante deste caso, a partir da análise dos princípios da proporcionalidade, da razoabilidade e da isonomia. O método de abordagem será o dedutivo, que se dará através da pesquisa exploratória, baseado nos livros e teorias que fundamentam a atemática desta pesquisa. Ao final, concluiu-se que ainda não houve um desfecho específico, mas pode ser observado uma tendência a um posicionamento voltado à liberdade religiosa.
Factors controlling spatiotemporal variability of soil carbon accumulation and stock estimates in a tidal salt marsh
Authors: Fettrow Sean , Wozniak Andrew , Michael Holly A. , Seyfferth Angelia L.
Published: May 2024

Abstract. Tidal salt marshes are important contributors to soil carbon (C) stocks despite their relatively small land surface area. Although it is well understood that salt marshes have soil C burial rates orders of magnitude greater than those of terrestrial ecosystems, there is a wide range in accrual rates among spatially distributed marshes. In addition, wide ranges in C accrual rates also exist within a single marsh ecosystem. Tidal marshes often contain multiple species of cordgrass due to variations in hydrology and soil biogeochemistry caused by microtopography and distance from tidal creeks, creating distinct subsites. Our overarching objective was to observe how soil C concentration and dissolved organic carbon (DOC) vary across four plant phenophases and across three subsites categorized by unique vegetation and hydrology. We also investigated the dominant biogeochemical controls on the spatiotemporal variability of soil C and DOC concentrations. We hypothesized that subsite biogeochemistry drives spatial heterogeneity in soil C concentration, and this causes variability in total soil C and DOC concentrations at the marsh scale. In addition, we hypothesized that soil C concentration and porewater biogeochemistry vary temporally across the four plant phenophases (i.e., senescence, dormancy, green-up, maturity). To test these interrelated hypotheses, we quantified soil C and DOC concentrations in 12 cm sections of soil cores (0–48 cm depth) across time (i.e., phenophase) and space (i.e., subsite), alongside several other porewater biogeochemical variables. Soil C concentration varied significantly (p < 0.05) among the three subsites and was significantly greater during plant dormancy. Soil S, porewater sulfide, redox potential, and depth predicted 44 % of the variability in soil C concentration. There were also significant spatial differences in the optical characterization properties of DOC across subsites. Our results show that soil C varied spatially across a marsh ecosystem by up to 63 % and across plant phenophase by 26 %, causing variability in soil C accrual rates and stocks depending on where and when samples are taken. This shows that hydrology, biogeochemistry, and plant phenology are major controls on salt marsh C content. It is critical to consider spatiotemporal heterogeneity in soil C concentration and porewater biogeochemistry to account for these sources of uncertainty in C stock estimates. We recommend that multiple locations and sampling time points are sampled when conducting blue C assessments to account for ecosystem-scale variability.