bluuebunny/crossref_metadata_2025 huggingface dataset:
USING LSTM NETWORK FOR SOLVING THE MULTIDIMENTIONAL TIME SERIES FORECASTING PROBLEM
Authors: Obrubov M. , Kirillova S.
Published: July 2021

The article discusses using of the recurrent neural networks technology to the multidimensional time series prediction problem. There is an experimental determination of the neural network architecture and its main hyperparameters carried out to achieve the minimum error. The revealed network structure going to be used further to detect anomalies in multidimensional time series.
COMPLEX COMPOUNDS OF LANTANOIDS WITH 4 - [(2,4-DIMETOXYBENZYL) AMINO] BENZOIC ACID.
Authors: Shamsutdinova M. , Dzhebirkhanova F.
Published: July 2021

The synthesis of complex compounds of 4 - [(2,4-dimethoxybenzyl) amino] benzoic acid (HL) with ions of samarium (III), europium (III), terbium (III), gadolinium (III) and dysprosium (III). According to the data of elemental analysis and thermogravimetry, the obtained complexes are hydrates of the composition LnL3 · nH2O, where n = 0-2. The area of their thermal stability is in the range from 100 ° С to 150 ° С. Electronic and infrared absorption spectra of the ligand and complexes with rare-earth metal ions have been measured. According to the IR spectra, the coordination of the ligand with the metal ion occurs at the carboxyl group. The carboxyl group is bidentate coordinated. To excite luminescence, a line of a mercury lamp with a wavelength of 248 nm was used.

The highest luminescence intensity is observed for the coordination compounds Eu3 +, Tb3 +, Sm3 +, and Dy3 +.
Writing for Players
Authors: Kelly Matthew
Published: July 2021

This article describes a technical writing assignment that requires students to use Minecraft to design and document interactive learning environments. In this project, students balance a critical awareness of this game's technical features with a rhetorical understanding of how those features impact the audience’s experiences and actions. This article demonstrates how video game-based writing projects can help students understand the role of an audience's agency in technical communication.
Multifaceted Editing and Reflection Project
Authors: Loewe Drew
Published: July 2021

This article describes a major assignment in an undergraduate editing course in the Writing and Rhetoric major at St. Edward’s University. The DEE-CR (Describe, Evaluate, Edit, Communicate, Reflect) project assignment is an individual assignment that asks students to find a particular non-fiction text that would benefit from the attention of an adept editor, to describe and contextualize it, to evaluate it, to edit it, to practice communicating edits to an author, and finally to reflect on lessons learned. I will describe the assignment’s design and purposes, reflect on some outcomes and challenges, and close by offering advice to readers of Prompt who might consider adapting the assignment for their courses.
Hijama
Authors: Auwal Umuruddeen
Published: July 2021

Hijama
The outbreak of lung injuries often known as "EVALI" was nothing to do with nicotine vaping
Authors: Bates Clive
Published: July 2021

Many commentators, activists, academics and public health agencies continue to assert or imply that an outbreak of serious and fatal lung injuries that occurred primarily in the United States between mid-2019 and early 2020 may have been caused in part by nicotine vaping. This condition is often known as “EVALI” (E-cigarette, or Vaping, product use-Associated Lung Injury), a term coined by the US Centers For Disease Control and Prevention (CDC). However, an examination of the evidence shows that _EVALI cannot have been caused by nicotine vaping_. The characteristics of the lung injury outbreak are consistent with localised supply chain contamination. The contaminant has been identified and is known to be Vitamin E Acetate.  This had been used a thickener or cutting agent in illicit Tetrahydrocannabinol (THC) cannabis vape pens. This agent cannot be added to nicotine vaping liquids and would serve no useful purpose if it could be. No other or cause or causal agent has been identified that would implicate nicotine liquids and that would be consistent with the geographical and temporal pattern of this lung injury outbreak. There is a vanishing small chance that a second cause would be found in nicotine liquids, coinciding with the same geography, timing and symptoms as Vitamin E Acetate contamination of THC oils. Further, it is highly unlikely that this hypothetical and currently unidentified cause would disappear in early 2020 without some identifiable remedial action in nicotine vaping products.  But there has been no identifiable remedial action - nicotine vaping products have not changed, but EVALI has largely gone. The attribution of EVALI to nicotine vaping should stop, the term EVALI should be replaced, risk communicators should shoulder their responsibility to correct residual false risk perceptions, and serious consideration given to the advantages of legalising and regulating cannabis products.
Analysis of Communication of Swadaya Oil Palm Farmers in District of Bagan Sinembah, Rokan Hilir Regency
Authors: Kirana Nina , Yulida Roza , Andriani Yulia
Published: July 2021

This research aims to determine the internal characteristics and external characteristics of the palm oil independent smallholder farmer and communication process (elements of communication) in Bagan Sinembah district, Rokan Hilir Regency. Bagan Sinembah district is a district in Rokan Hilir Regency, where the population of palm oil is cultivated. Therefore, it is necessary to analyze the characteristics of internal and external palm oil independent smallholder farmer as well as the process of communication using the survey method, selection of samples with purposive sampling methods and analysis tools Likert scale and Descriptive analysis. The results showed that the internal characteristics and external characteristics of oil palm farmers in Bagan Sinembah District, Rokan Hilir Regency are in high category (good). While the communication process in this research is seen from the elements of communication consist of extension, group chairman and management of KUD as communicator; The message is about oil palm cultivation techniques, market prices and so on which are summarized in the agribusiness system; Media used for face-to-face meetings (lectures and discussions); Farmers as communfishes; The effect of increasing knowledge, belief and behavioral change; The feedback gained is that the farmer understands with the information provided and applies the information in his venture; Physical environment namely the village hall, APKASINDO office and oil palm plantation land owned by the farmer.
Oil Palm Farmer’s Income Using a Combination of Organic and Non Organic Fertilizers in Sialang Palas Village Lubuk Dalam District Siak Regency
Authors: Situmorang Diana Silfia , Yusri Jum’atri , Yusmini Yusmini
Published: July 2021

Various efforts have been made by the government in business development and improving the welfare of oil palm farmers. One of the programs announced by the government is the cattle and oil palm integration system program (SISKA). In general, farmers in Riau Province use non -organic fertilizers as input in oil palm plantations. However, with the SISKA program, oil palm farmers began to apply organic fertilizer from cattle waste to oil palm. Oil palm farmers who have applied organic fertilizer or precisely combined organic fertilizer with non -organic fertilizer are found in Sialang Palas Village, Lubuk District, Siak Regency. The use of organic fertilizer has emerged since the introduction of the SISKA program in Sialang Palas Village in 2013. This study aims to determine cultivation, productivity and income of oil palm plantation farmers who combine organic and non -organic fertilizers in Sialang Palas Village, Lubuk Dalam District, Siak Regency. The research method used is the survey method. Sampling was done with a simple random sampling technique. The data analysis used is descriptive analysis and agricultural analysis. Descriptive analysis was used to describe the nature of oil palm farming in Sialang Palas Village. Farm business analysis includes business cost, income and efficiency analysis. The results showed that the fertilizer given consisted of a combination of organic and non -organic fertilizers with the amount of fertilizer given that is cow feces 2,101 kg/ha/year, cow urine 700 kg/ha/year, KCL 20.83 kg/ha/year, Dolomite 252 , 80 kg/ha/year and Phonska 90.83 kg/ha/year. The productivity is 18,578 kg/ha/year with a plant age of 32 years. Total production cost Rp.7.717.345/ha/year which consists of fixed cost Rp.1.364.333.56/ha/year and variable cost Rp.6.353.012.42/ha/year. The net income received by farmers is Rp.16,859,773/ha/year.
Halaman Depan Jurnal Sisfokom (Sistem Informasi dan Komputer) Vol. 8 No. 1 2019
Authors: Sisfokom Editor in Chief
Published: July 2021

This article contains front-matter of Sisfokom, Volume 8 Number 1 March 2019, which includes a cover page, title page, editorial team, and table of contents.
Halaman Depan Jurnal Sisfokom (Sistem Informasi dan Komputer) Vol. 8 No. 2 2019
Authors: Sisfokom Editor in Chief
Published: July 2021

This article contains front-matter of Sisfokom Journal, Volume 8 Number 2 Year 2019, which includes a cover page, title page, editorial team, and table of contents.
Front Cover Jurnal Sisfokom (Sistem Informasi dan Komputer) Vol. 9 No. 1 Maret 2020
Authors: Sisfokom Editor in Chief
Published: July 2021

This article contains front-matter of Jurnal Sisfokom (Sistem Informasi dan Komputer), Volume 9 Number 1 - March 2020, which includes a cover page, title page, editorial team, and table of contents.
Back Cover Jurnal Sisfokom (Sistem Informasi dan Komputer) Vol. 9 No. 1 Maret 2020
Authors: Sisfokom Editor in Chief
Published: July 2021

Back Cover Journal
Back Cover Jurnal Sisfokom (Sistem Informasi dan Komputer) Vol. 9 No. 2 Juli 2020
Authors: Sisfokom Editor in Chief
Published: July 2021

Back Cover Journal
НОРМАТИВНО-ПРАВОВЕ ЗАБЕЗПЕЧЕННЯ ЕКОНОМІЧНОЇ ЕКСПЕРТИЗИ: СТАН ТА ВДОСКОНАЛЕННЯ
Authors: Мулик Ярославна
Published: July 2021

У статті досліджено основні нормативно-правові акти, що регулюють порядок організації та проведення судових експертиз та роботу експертів. Охарактеризовано структуру та зміст розділів Закону України «Про судову експертизу», представлено погляди науковців на питання, що потребують змін та вдосконалення. Охарактеризовано зміст Інструкції про призначення та проведення судових експертиз та експертних досліджень № 53/5 та необхідність її вдосконалення а також Науково-методичні рекомендації з питань підготовки та призначення судових експертиз та експертних досліджень. Досліджено права, обов’язки та відповідальність, що регулюються різними нормативно-правовими актами, визначено, які є неточності та недоліки. Запропоновано розширення правових функцій судового експерта-економіста. Досліджено нормативні акти в сфері атестації судових експертів. Представленні в дослідженні удосконалення нормативно-правої бази судово-економічних експертиз, впливатимуть на підвищення ефективності проведення судово-економічних експертиз та роботи судових експертів.
PROSPECTS OF HARMONIZATION OF SOCIO-ECONOMIC INTERESTS OF LAND RELATIONS OF THE AGRICULTURAL SECTOR OF UKRAINE
Authors: Kotelenets Anastasiia
Published: July 2021

The article substantiates and formalizes the conceptual approach to balancing the socio-economic interests of
the subjects of land relations of the agricultural sector. The main elements of the mechanism of socialization of the
system of land relations regulation are determined, which are: 1) increasing the level of social responsibility of the
state to society and business in regulating land relations, which is to ensure fair distribution of land rights between
land relations and land productivity. on the basis of socialization of land legislation; 2) ensuring the rapid and effective
resolution of conflicts of interest of the subjects of land relations related to the violation of land ownership rights,
through the introduction of the institution of land mediation; 3) expanding public participation in the processes of
defining goals and programs of land reforms according to the interactive model of crowdsourcing start-up. It is proved
that the institute of public-private partnership in the system of land relations regulation can serve as an effective
means of realization of socially significant projects in the agricultural sector and development of the administration system in the direction of its social stabilization and coordination of interests of land relations subjects. the statebusiness alliance to the format of multilateral partnership in order to maximize the involvement of the active part
of society in a broad dialogue in the preparation and implementation of land reform projects. Partnership between
government, business and the public in the framework of social responsibility will contribute to the sustainable
development of society, reduce non-financial risks for corporations and serve as a prevention of social crises. Thus,
the balance of interests of agribusiness, society and the state, the instrument of which is the socialization of land
relations, will balance the aspirations of agricultural holdings and small agricultural enterprises to maximize profits,
rural population – to a fairer distribution of land resources, the state – to socio-political stability land relations.
Performance of Composite Shear Walls Subjected to In-plane Cyclic Loading - A Numerical Parametric Study
Authors: Labibzadeh Mojtaba , Salehnia Anis , Hossain Khandaker M. A. , Jing Deng-Hu
Published: July 2021

An RC shear wall (wall1), a composite shear wall composed of a single external steel plate connected to a concrete panel (wall2), a composite shear wall constructed from two external steel plates connected to an internal concrete panel (wall3) and finally a composite shear wall fabricated with a single internal steel plate embedded within a concrete panel (wall4) are considered in this study and their behavior are assessed and compared under the effect of an in-plane cyclic load. Variation of the three functions include shear load capacity, energy absorption and shear stiffness of the walls are evaluated numerically using the ABAQUS finite element software. The performance of numerical models is validated against to the experimental results. The effects of four parameters consisting of compressive strength of concrete, yield strength of steel plate, height-to-length ratio of the wall and the thickness of the steel plate are investigated on the above-mentioned functions. Obtained results show that the wall4 has the best performance among all four types of shear walls. For instance, the energy absorption capacity of the wall4 is approximately two times greater than that of wall1 and wall2.
Entrepreneurship and Regional Growth Regimes in the United States
Authors: Appert John , Can Ege , Fossen Frank M.
Published: July 2021

We investigate

regional growth regimes in the US states from 1980 to 2014. Based on start-up

rates and employment growth as suggested by Audretsch and Fritsch (2002), we

classify states into routinized, entrepreneurial, revolving door, and

downsizing regimes. The results indicate that there was no significant

association between start-up rates and employment growth in the 1980s, but a

positive relationship in the 1990s, 2000s, and 2010s. Further, we document that

the entrepreneurial and the downsizing regimes are attractor regimes that tend

to stick, whereas the routinized and revolving door regimes are transitionary

regimes. Importantly, states in the routinized regime predominantly move to the

downsizing regime, suggesting that an over-reliance on established companies

relative to start-ups in the state may threaten employment growth in the long

run.
Doświadczenia z przeszłości kanwą do budowania przyszłości nauk o zarządzaniu
Authors: Bojar Ewa , Głodziński Eryk
Published: July 2021

Artykuł ma na celu przedstawienie założeń projektu o nazwie „Środowisko naukowe. Mistrzowie, współpracownicy, uczniowie. Przeszłość, teraźniejszość, przyszłość”. Jego ideą jest zaproszenie środowisk nauk o zarządzaniu w ujęciu instytucjonalnym do opracowania artykułów prezentujących ich tożsamość na gruncie historycznym i prezentujących przyszłość nauk o zarządzaniu z ich perspektywy. W opracowaniu podkreślono, że nauki o zarządzaniu rozwijają się dynamicznie, posiadają bogaty własny dorobek wpływający na rozwój społeczno-gospodarczy. W artykule wskazano, że przedstawienie panoramy środowisk naukowych w kontekście mistrzów i wkładu teoretycznego, metodycznego czy aplikacyjnego będzie stanowić obraz historyczny nauk o zarządzaniu w kontekście ich najbliższych wyzwań.
Zarządzanie wielopoziomowe w etnopolityce wybranych państw Europy Wschodniej
Authors: Karolak-Michalska Magdalena
Published: July 2021

Celem artykułu jest wskazanie elementów modelu wielopoziomowego zarządzania możliwych do wdrożenia w etnopolityce wybranych państw Europy Wschodniej. Autorka w pierwszej części tekstu pisze, czym jest zarządzanie wielopoziomowe, następnie rozważa, na ile realne jest wdrożenie modelu zarządzania wielopoziomowego w zarządzaniuetnopolityką w państwach subregionu. W uwagach końcowych dochodzi do wniosku, że istnieją elementy modelu wielopoziomowego zarządzania możliwe do wdrożenia w etnopolityce wybranych państw Europy Wschodniej.
Czynniki kształtujące podmiotowość pracownika a osiągnięcie sukcesu zawodowego w optyce pracownika
Authors: Nogalski Bogdan , Kozłowski Andrzej Józef , Czaplicka-Kozłowska Iwona Zofia
Published: July 2021

Minione lata w Polsce, podobnie jak we wszystkich państwach o

rozwiniętej cywilizacji opierającej się o nowoczesne systemy zarządzania, były

dążeniem do maksymalnego wykorzystania technologii oraz kapitału

intelektualnego do osiągnięcia jak największych rezultatów w procesie

wytwarzania. Można przyjąć, że dokonujący się postęp technologiczny przekłada

się na stosunki społeczne i oddziałuje na kształtowanie relacji pracowniczych

stanowiących zbiór czynników wpływających na zachowania pracownicze. W

prezentowanym opracowaniu odniesiono się do zarządzania kadrami w obszarze

czynników funkcjonujących na stanowisku pracy i przekładających się na odczucie

sukcesu. Badania przeprowadzono w różnych organizacjach celem wskazania i

porównania czynników wpływających na podmiotowość pracowników. Podstawowy

problem podjęty w opracowaniu sprowadzono do poszukiwania odpowiedzi na

pytanie, jakie czynniki i w jakim stopniu wpływają na zachowania pracowników oraz

wiążą się z osiągnięciem sukcesu zawodowego. Badania

wykazały duże różnice w opiniach pracowników badanych organizacji. Można

przyjąć, że podmiotowość pracowników i odczucie tej podmiotowości najczęściej

występuje w organizacjach prywatnych a w najmniejszym stopniu w organizacjach

zhierarchizowanych, szczególnie mundurowych.
ACTANTIAL MODEL IN THE NELYUBOV MOVIE
Authors: Haryadi Jasmine Disca , Kaprisma Hendra
Published: July 2021

Through the characters of Zhenya and Boris, the film Nelyubov (2017) explores the issue of a toxic marriage. The story's theme reflects the complexities of the characters' relationships and the resulting problems. This theme adds intrigue to the film's problem articulation, particularly how the film's conflict can be constructed. Accordingly, this study seeks to identify the actant schemes created in the Nelyubov film. This study examines the location of individuals in the film using Algirdas Julien Greimas' Actantial Model theory. Further, this article employs Mills' Discourse Analysis and Smith's Interpretative Phenomenological Analysis (IPA). The results indicate representations for the subject, object, helper, opposer, sender, and receiver in the Nelyubov film, allowing for the fulfillment of the three kinds of axis: the axis of desire, the axis of power, and the axis of transmission/knowledge. The film's subject is Zhenya, and the object is the happiness he seeks.
SOCIAL CRITICISM IN THE MISTER FRIMEN ANIMATED SERIES
Authors: Ristiasari Riska , Kaprisma Hendra
Published: July 2021

Social criticism is generally comprised of individuals' ideas and opinions of societal problems that bring changes. Individuals can express their opinions through various media, including animated films. The animated series Mister Frimen created by Pavel Muntyan, Vladimir Ponomarev, Anatoly Dobrozan, and Vadim Demchog are notoriously sarcastic. The sarcastic remarks given by the main character are always about current problems in Russian society. This study focuses on the way the animated series Mister Frimen expresses social problems. This article uses intertextual theory and discourse analysis to analyze every message and symbol and how the messages are generated. The results show that each scene in Mister Frimen contains symbols illustrating social criticism messages about the situation of Russian society. Nonetheless, satire/social criticism offers suggestions for establishing societal peace and prosperity
METAPHOR IN THE FILM SETAN JAWA
Authors: Fenda Intan Yulia Febbyu , Handriyotopo Handriyotopo
Published: July 2021

The Setan Jawa film depicts the two main characters' fascinating and expressive body language and motions (Setio and Asih). Accordingly, we formulate the research problem of the Setan Jawa film’s metaphor values. This study uses the metaphorical approach to search for the meanings of the film by analyzing the source and target domains. Our findings indicate that Setan Jawa encompasses both the romance source domain and the tragedy target domain. In sum, Setan Jawa is a film about perseverance, courage, intention, self-sacrifice, and ambition.
Rebranding of Poso Regency Tourism After Social Conflict
Authors: Akifah Andi , Alfiyaty Rizqy , Monica Nabillah Sasha
Published: July 2021

After the social conflict with the issue of ethnicity, religion, race and inter-group. the image of Poso Regency has changed to become a "City of Conflict". This study aims to determine the rebranding process carried out by the Poso Regency Tourism Office in changing the image as a conflict area that is already attached. This study uses qualitative methods through observation and in-depth inteviews with selected informants by purposive sampling technique. The results of the study shows that in carrying out the rebranding process, the Poso regency tourism office has done several things, including trying to promote its area as a safe, peaceful and fair area through participation in various tourism events at both domestic and overseas; Cooperating with security forces in creating safe conditions in the Poso Regency area; Changing the tourism tagline, which was originally “mandago-dago ri tanah Poso”, then became “the land of thousand megaliths” to introduce the uniqueness of Poso land which has many historical relics in the form of megalithic statues. The final process is to publish all changes and carry out large-scale promotions through mass media, both conventional and contemporary
Peningkatan Kesadaran Perilaku Hidup Bersih dan Sehat (PHBS) pada Anggota Karang Taruna Desa Paya Rengas Kecamatan Hinai Kabupaten Langkat
Authors: Humaizi Humaizi , Yusuf Muhammad
Published: July 2021

Berdasarakan analisis situasi yang didapat dari KKN Mahasiswa Universitas Sumatera Utara tahun 2019 di Desa Paya Rengas Kecamatan Hinai Kabupaten Langkat terdapat permasalahan masih rendahnya kesadaran perilaku hidup bersih dan sehat (PHBS.  Untuk  meningkatkan kesadaran terhadap perilaku hidup bersih dan sehat (PHBS) anggota karang taruna di desa paya rengas, perlu dilakukan kegiatan melalui diskusi, dan sosialisasi. Lokasi kegiatan pengabdian ini berada di Desa Paya Rengas Kecamatan Hinai Kabupaten Langkat. Tahapan kegiatan pengabdian ini telah dilaksanakan dengan melakukan survei lokasi pengabdian, penyiapan lokasi pengabdian, dan pemberian alat penunjang PHBS. Kegiatan sosialisasi tentang PHBS kepada anggota karang taruna telah dilaksanakan dengan metode ceramah, diskusi dan tanya jawab. Secara umum, kegiatan pengabdian ini berjalan dengan lancar. Berdasarkan hal tersebut, kesimpulan yang dapat ditarik adalah bahwa peserta kegiatan pengabdian mengerti bahwa perilaku hidup bersih dan sehat sangat penting untuk mencegah berbagai penyakit merupakan bagian dari ajaran agama yang memiliki banyak keuntungan.
Edukasi Covid-19 dan Social Distancing Kepada Kelompok Warga Penerima Bantuan Program Keluarga Harapan (PKH) Di Kelurahan Surabaya Kota Bengkulu
Authors: Dalifa Dalifa , Kustianti Sri Ken , Agusdianita Neza , Anggraini Dwi
Published: July 2021

Pada masa pandemi virus covid-19 ini masyarakat membutuhkan edukasi agar dapat terhindar dari paparan virus ini. Tujuan dari kegiatan ini adalah untuk memberikan edukasi Covid-19 dan social distancing kepada kelompok warga penerima bantuan progam keluarga harapan (PKH) di Kelurahan Surabaya Kota Bengkulu. Metode yang digunakan pada kegiatan PPM ini adalah pendampingan kepada masyarakat sasaran melalui grup whatsapp dan dilengkapi dengan buku saku. Instrumen yang digunakan dalam kegiatan PPM ini adalah lembar angket pemahaman masyarakat sasaran mengenai Covid-19 dan social distancing. Analisis data kegiatan ini secara deskriptif kualitatif. Hasil penelitian ini ialah telah terlaksana kegiatan pendampingan edukasi Covid-19 dan social distancing kepada kelompok warga penerima bantuan progam keluarga harapan (PKH) di Kelurahan Surabaya Kota Bengkulu dengan baik. Terdapat peningkatan pemahaman warga mengenai wabah Covid-19 dan social distancing melalui kegiatan pendampingan dengan grup whatsapp dilengkapi dengan buku saku mengenai Covid-19. Luaran dari kegiatan ini adalah publikasi pada jurnal, buku saku dan publikasi video kegiatan di youtube channel.
Una strana colica renale destra
Authors: Fioravanti Gilda , Fioravanti Giuseppe
Published: July 2021

Abstract non disponibile
Il confondimento: un bias della stima dell’effetto fra una esposizione ed un esito di salute
Authors: Franco Francesco , Di Napoli Anteo
Published: July 2021

Abstract non disponibile (Epidemiology_statistics)
Riflessioni (provocatorie?) dopo la frequenza di alcuni incontri di Medicina Narrativa e non solo
Authors: Lombardi Marco
Published: July 2021

Abstract non disponibile
Evoluzione della ricerca scientifica nell’ambito della biologia umana: abbiamo raggiunto il momento in cui dobbiamo fermarci e riflettere?
Authors: Barracca Antonio , Patricelli Patrizia Francesca , Milani Maria Rinaldi , Quintaliani Giuseppe
Published: July 2021

No one wants to question the scientific method, which is the method science uses to proceed and expand our knowledge of the reality. However, we can ask ourselves if scientific research has limits that we cannot overcome? In 1942, Julius Robert Oppenheimer, who ran the Manhattan project to develop the first atomic bomb, was the first to understand that the limits should not be overcome in scientific research. With the discovery of the molecular structure of the nucleic acid, and its meaning in the transmission of information in living beings, we have entered the knowledge of the "mysteries" of life. We have learned to read DNA, to write it and to modify it, cutting defective parts with the CRISPR/Cas9 technique. With genetic editing we can not only avoid many diseases, but also modify the DNA sequence in future generations. Have we reached a point where we must stop? Perhaps we must begin to consider that science must progress together with philosophical and ethical thought in the interest of the community. (Clinical_Management)
Interazione: modificazione dell’associazione tra esposizione ed esito al variare di un terzo fattore
Authors: Franco Francesco , Di Napoli Anteo
Published: July 2021

From a statistical perspective, interaction (effect modification) occurs when the effect of an exposure on an outcome depends on the level of another factor. In epidemiology, effect modification (interaction) occurs if the joint effect of two (or more) factors is different from the expected effect if considering only their independent effects. In an additive model, the effect of one exposure is added to effect of another exposure, and there is interaction if the joint effect of the two exposures together is greater than the sum of their individual effects. In a multiplicative model, the effect of the second exposure multiplies the effect of the first exposure, and there is interaction if the joint effect of the two exposures together is greater than the product of their individual effects. Interaction of two (or more) factors is synergic or antagonistic if the total effect is, respectively, greater or smaller than the sum of the individual effects of each factor. (Epidemiology_statistics)
L’impegno di Aiaf Onlus per migliorare la presa in carico dei pazienti con Anderson-Fabry
Authors: Tobaldini Stefania
Published: July 2021

Abstract non disponibile.
Persone come noi: Intervista a Rita
Authors: Tobaldini Stefania
Published: July 2021

Abstract non disponibile.
Rivaroxaban e malattia renale cronica: evidenze dal presente e prospettive future
Authors: Di Lullo Luca , Ronco Claudio , Floccari Fulvio , De Pascalis Antonio , Barbera Vincenzo , Rivera Rodolfo , Bellasi Antonio
Published: July 2021

Cardiovascular diseases represent the main cause of comorbidly in chronic kidney disease (CKD) patients, with a 7% incidence in atrial fibrillation (AF) in end-stage renal disease (ESRD) patients. Until recently, prophylactic treatment of atrial fibrillation complications (such as thromboembolism) was mainly based on vitamin K antagonists (VKA) or heparin. In the last years, direct oral anticoagulants (DOACs) have been made available; however, their renal clearance limits their use on patients with severe renal impairment (eGFR <15 mL/min). Among DOACs, Rivaroxaban, a factor X-activated (Xa) inhibitor, shows good renal profile and it can be used in CKD patients up to stage 4 as well as in ESRD patients (at the moment only in North America and Canada). (Cardionephrology)
“La qualità della vita dei pazienti Fabry”: presentati da Aiaf i risultati dell’Indagine Nazionale in occasione del Meeting Nazionale Pazienti Anderson-Fabry 2019
Authors: Tobaldini Stefania
Published: July 2021

Abstract non disponibile.
Buona primavera ai Soci AIRP
Authors: Sternfeld Pavia Luisa
Published: July 2021

Abstract non disponibile.
Il paziente con rene policistico negli ambulatori italiani
Authors: Dorigo Emanuela , Sternfeld Pavia Luisa
Published: July 2021

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. PKD is a multisystem disorder associated with multiple bilateral renal cysts, slowly increasing kidney size and progressive chronic kidney disease. Approximately 50% of individuals with PKD will require renal replacement therapy by the sixth decade of life. More than 80% will also have multiple liver cysts, which can lead to local pressure effects. Cerebral haemorrhage, secondary to rupture of a berry aneurysm, occurs in up to 8% of individuals. Mitral valve prolapse occurs in up to 25% of patients. Patients with ADPKD have a worsening in the quality of life and a burden of disease similar to cancer patients. The quality of correct information given to patients and a warm reception have a positive impact on patients with ADPKD and contribute to an efficacious treatment program. AIRP conducted a survey to investigate the ADPKD patient journey, meaning the personal experience and expectations of people regarding factors such as disease management, relationships with the nephrologists and their team, and therapies. The survey was conducted on 370 people with ADPKD, using computer-assisted web interviewing (CAWI). The results show that patients with ADPKD with a good relationship with their care team, both nephrologist and nurse, respond better to therapies. Warm reception, dialogue, communication, support, clear explanation, reassurance and guidance altogether contribute to a successful treatment of every single person with ADPKD.
Il progetto di un fumetto nelle scuole per la cultura della donazione
Authors: Catania Battista
Published: July 2021

Abstract non disponibile.
La patologia da Citomegalovirus nel paziente portatore di trapianto renale: impatto, prevenzione e trattamento
Authors: Alfieri Carlo , Gandolfo Maria Teresa , Favi Evaldo , Tangredi Marianna , Monciino Paola , Messa Piergiorgio
Published: July 2021

Renal transplantation (RT) is considered the best therapy for patients with chronic renal failure. Renal transplant patients have an elevated risk of infections, and viral diseases have a high prevalence, especially during the first year after RT. Viral infections might influence, in the short and long term, the graft outcome and the patient’s survival. Cytomegalovirus (CMV) disease can be particularly dangerous in immunosuppressed patients and its evaluation is important in the follow-up of RT. The aim of this review is to present a brief analysis of the epidemiology, clinic characteristics and methods currently available to the clinician for the diagnosis of CMV diseases. The impact, risk factors, main preventive and therapeutic measures currently available to manage CMV diseases in the early stages of RT will also be described, referring to the recent guidelines on the CMV management in transplanted patients.
Persone come noi: Intervista a Mariella
Authors: Tobaldini Stefania
Published: July 2021

Abstract non disponibile.
Preeclampsia Part 2: fisiopatologia e trattamento
Authors: Michelassi Stefano
Published: July 2021

Preeclampsia is a pregnancy-specific disorder usually defined as new-onset hypertension and proteinuria after the 20th week of gestation. Preeclampsia is a systemic disease with multiorgan involvement, and it is associated with a high risk of maternal and fetal morbidity and mortality. To date its pathogenesis is not completely understood, but placental hypoxia or hypoxia/reoxigenation may be the basic condition leading to systemic inflammation and endothelial dysfunction that induce all the clinical manifestations of the disorder. Delivery is the only curative treatment. Indeed, for the management of preeclampsia one needs to consider both the maternal risks due to continued pregnancy and the fetal risks associated with induced preterm delivery.
Quali alterazioni dell’esame urine possono preludere ad un interessamento renale della malattia di Fabry
Authors: Feriozzi Sandro , Mangeri Mario
Published: July 2021

The markers of renal involvement in Anderson-Fabry disease are defects of urine concentration, presence of cells with lipid cytoplasmatic inclusions (mulberry bodies) and podocyturia. The loss of urine concentrating capacity is not easy to detect and the search for cellular inclusions is a complex technique. Moreover, none of the markers has any clear correlation with the stage of the disease. The occurrence of podocytes in the urine (podocyturia) correlates with both renal involvement and clinical outcome; therefore, podocyturia seems to be a promising early indicator of nephropathy. However, a common agreement on the laboratory assay used to measure is still needed.
Ultrafiltrazione peritoneale e sindrome cardiorenale: gestione del sovraccarico di fluidi e ruolo del sodio
Authors: Di Lullo Luca , Ronco Claudio , Floccari Fulvio , De Pascalis Antonio , Rivera Rodolfo , Granata Antonio , Bellasi Antonio
Published: July 2021

Congestion represents a crucial clinical component of both heart failure and cardiorenal syndrome and it has been postulated to modulate heart and kidney cross-link. Diuretic therapy is a corner stone in the treatment patients with heart failure, and renal replacement therapies are mainly used for patients with refractory heart failure who have not reached the worst stages of renal disfunction. Peritoneal dialysis is a home-based therapeutic modality providing both solute clearance and ultrafiltration, together with relief from congestion in decompensated heart failure patients. The following review will focus on sodium removal in refractory decompensated heart failure patients undergoing peritoneal dialysis. (Cardionephrology)
Una Giornata Mondiale del Rene molto particolare e molto narrativa!
Authors: Canclini Gianluigi , Carla Colturi
Published: July 2021

The World Kidney Day (WKD) 2016 in Bormio took place in a primary school, with two classes of the 5th grade. After being introduced by Dr. Colturi, Gianluigi narrated his experience as a kidney patient, dialysed and transplanted. In this contribution, the two authors report the statements collected from some students. The enormous curiosity and the great and heartfelt participation of children confirm - if there were any need - the importance of storytelling and ‘literacy’ in this health case at any level. (narrative nephrology)
La gestione della terapia ipoglicemizzante nel paziente con nefropatia da diabete mellito tipo 2
Authors: Manetti Francesco
Published: July 2021

Chronic kidney disease (CKD) is constantly increasing in terms of prevalence and incidence. Subjects with impaired renal function, even if only in the presence of micro/macroalbuminuria, have an increased cardiovascular risk profile. Therefore, we must pay particular attention to the treatment of all associated risk factors. Therapy with oral hypoglycemic agents often requires modulation of drug dosage based on kidney function. Today, there are molecules available that are able not only to induce cardiovascular protection, but also to slow the progression of renal damage.
La terapia enzimatica sostitutiva nella malattia di Fabry
Authors: Roggero Letizia , Auricchio Sara , Pieruzzi Federico
Published: July 2021

Anderson-Fabry disease (FD) is a X-linked lysosomal storage disorder, which involves glycosphingolipids metabolism. Specific treatment for FD has been available in the last two decades, after the development and commercialization of recombinant human alfa-galactosidase A. Since then enzyme replacement therapy (ERT) has changed the natural history of the disease. Two different enzymatic formulations are available: agalsidase alfa and agalsidase beta at different dosages. The safety and efficacy profiles are similar. ERT induces Gb3 deposits reduction in renal and cardiac biopsies, improves quality of life, reduces pain and GI symptoms, decreases left ventricular mass and slows down renal function decline. In case of organ involvement, clinical evidence confirms the need to treat all patients with enzyme therapy, both male and female. In all other clinical settings, the decision to start ERT is controversial, because of the extremely variable clinical manifestations of FD. However, data suggest a greater response to ERT if started as early as possible in any patients. Timely treatment appears to be effective in stabilizing and possibly delaying FD progression. ERT infusion reactions due to allergic hypersensitivity or IgG antibody development could occur but can be easily managed. In-hospital and at home infusions are possible. The wide genetic and phenotypic heterogeneity observed in all FD patients requires a tailored approach to treatment options. Patients should be referred to an expert multidisciplinary team for the long term management of this challenging disease.
La terapia nella malattia di Fabry
Authors: Mignani Renzo
Published: July 2021

Abstract non disponibile.
Analysis of Cadre Compliance Levels in Running Health Protocol in the Era of Pandemic Covid-19 in Puskesmas Limo Depok
Authors: Wahyuningsih Sri , Yusmaini Hany , Harfiani Erna , Bahar Meiskha
Published: July 2021

Covid-19 outbreak that originated in Wuhan's city is spreading very quickly and is currently a pandemic worldwide. Transmission through droplets that come out of the patient's nose or mouth, whether symptomatic or asymptomatic.  Efforts to prevent and fight COVID-19 must be carried out jointly with the community's cooperation and require strong discipline by washing hands frequently, maintaining distance, wearing masks, staying at home, and increasing body power. The purpose of this study was to determine the level of cadre compliance  in carrying out health protocols in the era of the Covid-19 pandemic. This research method with a cross-sectional approach. The respondents were cadres of Limo Health Center, Depok. It was total sampling. The research instrument used a questionnaire of Google Form and analyzed using Chi-Square. The results showed that most of the respondents were included in the 46-60 year interval (51.4%) were highly educated, tertiary education (70%), knowledgeable (54.3%), unemployed (87.1), obeyed the protocol. Health (50%). Compliance increases in the elderly, higher education, sufficient knowledge, work status. conclusion there is no relationship between age (p = 0.632), education level (p = 0.794), knowledge level (p = 0.253), work status (p = 0.074) and compliance with the Covid-19 health protocol.
Nevus Comedonicus, a Rare Case : Dermoscopic and Histopathological Findings
Authors: Dharmawan Nugrohoaji , Ellistasari Endra Yustin , Oyong Oyong , Nareswari Adniana
Published: July 2021

Nevus comedonicus is an extremely rare adnexal hamartoma of pilosebaceous apparatus, with approximately 200 cases reported in the literature so far. It appears as cluster of adjacent honeycomb-like dillated follicular openings with firm pigmented keratin plugs resembling comedones.The comedones oftentimes arranged in linear pattern paralled to Blaschko’s lines. We report a case of a 5-year-old boy with open brown to black comedones in a linear pattern localized on the back of the left thigh that appearing since birth. Pain, itch and discharge were not obtain. There were some episodes of infection, due to manual removal done by his mother which left some hypertrophic scars. Dermoscopic examination revealed the distinctive pattern consisting of pigmented, sharply demarcated keratin plugs of 1-3 mm in diameter, some open pores, multiple structurless, various shades of brown homogenous circular areas surrounding the plugs. Histopathological examination showed an aggregation of dilated follicular infundibulum with laminated keratinous material plugging. This case report prove that dermoscopy examination, a simple non-invasive diagnostic tool is very helpful in diagnosing nevus comedonicus. We recommend this tool to differentiate the diagnosis of other rare epidermal nevi while histopathological examination should be performed only in uncertain cases.
Analysis of Recurrent Positive COVID-19 Patients in A Hospital
Authors: Durmus Ensar , Guneysu Fatih
Published: July 2021

The studies about COVID-19 began to show that people who have already had COVID-19 were re-admitted to the hospital due to COVID-19 positivity. This study aims to identify recurrent positive patients and the demographic characteristics of these patients. The number of recurrent COVID-19 positive patients  was 190. Of these patients, 97 (51.1%) were male, the average age was 43.98 years (±16.3), 147 (77.4%) were never hospitalized, Of the hospitalized patients, 28 (65.1%) were male and the average age of the inpatients was 54.67 years (±16.15). Looking at the duration of hospital stay of the inpatients, it was observed that the average was 11.16 days (±8.9). A positive correlation was found between the age of the patients and the duration of their hospital stay (r=0.386). The average time between the two positives was 52.92 days. Patients who have a recurrent positive result usually survive the disease with outpatient treatment for their mild illness. Hospitalization rates of male patients were higher than those of females, and the duration of hospital stay was found to increase as the age of the patients increases.
Decreas of BCL-2 Expression by Ethanol Extract of Ocinum basilicum L. Leaves in Breast Cancer Cells
Authors: Hidayati Devi Nisa , Zahroh Fatimatuz , Wahyuni Lina , Arifin Ibrahim
Published: July 2021

Ocimum basilicum L has proven to have in vitro cytotoxic activity against breast cancer cells. Pathways that cause cell death can involve one of the proteins, which is BCL-2. This study aims to determine the decrease of BCL-2 protein expressions in breast cancer cells (T47D and MCF-7) tat are treated with the ethanol extract of Ocimum basilicum L. Ocimum basilicum L. was extracted using the maceration method with 70% ethanol solvent. The concentration of ethanol extract of Ocimum basilicum L. used to see the expression of BCL-2 protein in T47D and MCF-7 cells was 199 µg/ml and 388 µg / mL. The observation of BCL-2 protein expression is using immunocytochemical methods of T47D and MCF-7 cancer cells. The results showed that the ethanol extract of Ocimum basilicum L could reduce BCL-2 protein expression in breast cancer cells (T47D and MCF-7) at concentrations of 199 µg/ml and 388 µg/ml, respectively.
Erectile Dysfunction and COVID-19: a Case Report
Authors: Mahardhika Gembong Satria , Maharani Nastiti , Tedjamartono Theodore Dharma , Ismail Efriadi
Published: July 2021

Coronavirus Diesease-2019 (COVID-19) infection is suspected to affect the sexual behavior and function. The vascular damage related to COVID-19 can affect the impairment of bed blood vessel of penile and finally make the erectile dysfunction (ED). This problem is one of the most common sexual problem in man, with the prevalantion between 13 until 28% at the 40-80 years old, and the incidence increases with higher age. At this time, no data about the effect of COVID-19 to sexual behavior. There was one case of COVID-19 with erectile dysfunction who was treated at Kemayoran Athletes Village COVID-19 hospital. Erectile dysfunction is influenced by several factors; including psychogenic, neurogenic, and infectious. The diagnosis of erectile dysfunction is determined based on the results of history taking and physical examination, using the standard questionnaire (IIEF-5/International index of erectile function-5). A further review is needed to exclude a particular cause, the management can be determined based on the etiology.
Environment and Mental's Health in The Pandemic Time Covid-19 in IGD Nurse Royal Prima Medan Hospital
Authors: Akbar Khainir , Nasution Sri Lestari Ramadhani , Girsang Ermi
Published: July 2021

The mental health of health workers during the COVID-19 pandemic period is a present issue that must be given more attention. It is because health workers are the spearhead of handling the COVID19 case, which is daily increasing. The purpose of the research to examine the mental health of IGD nurses at Royal Prima Hospital Medan by using variable demographic characteristics (age, gender, years of service), family environment, social environment, and work environment. This type of research is a quantitative study, with the research sample being all emergency room nurses at Royal Prima Hospital Medan. The data were processed using correlation analysis in SPSS. The results showed that the demographic characteristics, family environment, social environment, and work environment were positively correlated with mental health in IGD nurses at Royal Prima Medan Hospital. Suggestions for further research are to use a larger sample and be able to use other variables according to the theory of Cooper and Davidson
Limpasu Pericarpium : an Alternative Source of Antioxidant From Borneo with Sequential Maceration Method
Authors: Zamzani Irfan , Triadisti Nita
Published: July 2021

Antioxidants are substances that can slow down the oxidation process of free radicals. Limpasu plant (Baccaurea lanceolata (Miq) Muell. Arg), an indigenous plant of Borneo, is a natural antioxidant source. The purpose of this study was to determine the antioxidant activity of the limpasu pericarpium extract. The extraction of the limpasu pericarpium was done by maceration method using solvents with increasing polarity ranging from n-hexane, ethyl acetate, and methanol. Antioxidant activities of the three extracts were measured by the DPPH and FRAP methods. The IC50 values of n-hexane, ethyl acetate, and methanol extracts, as well as quercetin using the DPPH method were 517,45 µg/mL, 530,64 µg/mL, 10,63 µg/mL and 6,83 µg/mL, respectively. Meanwhile, the IC50 values obtained from FRAP method were 198,96 µg/mL, 190,07 µg/mL, 661,36 µg/mL, and 7,09 µg/mL, respectively. The results revealed that the methanol extract is more potent than other extracts tested for antioxidant activity.