bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the temperature-dependent mechanisms of viscoelasticity of sand-enhanced epoxy
Authors: Wang Xiaomeng , Wu Qian , Petrů Michal
Published: May 2024

The viscoelastic behavior of epoxy is critical for its engineering performance and applications. This work focused on the improvement of its viscoelastic performance by using natural sand particles as fillers. Experiments were carried out to investigate the static and dynamic viscoelastic properties of epoxy with various sand particle contents. Static mechanical tests demonstrated an increase in the elastic modulus, albeit at the cost of reduced strength at a higher sand content due to stress concentrations. Dynamic tests indicated substantially improved storage modulus and damping of epoxy after being filled with sand particles. Moreover, the glass transition temperature of epoxy showed a substantial rise upon the addition of sand particles, signifying an augmentation in its heat resistance. Static viscoelastic characterization revealed an elevation in both room- and high-temperature relaxation moduli upon incorporating sand. By applying time–temperature superposition principles, long-term relaxation curves were obtained, which could provide a reference for engineering design. These viscoelastic investigations offer insights into the underpinning mechanisms governing the performance of sand-reinforced epoxy. This enables the rational design of sand-particle-reinforced epoxy for customized durability, heat resistance and vibration damping.
La inminente reforma del sistema jurisdiccional de la Unión Europea
Authors: Kühn Baca Werner Miguel
Published: May 2024

El Tribunal de Justicia de la Unión Europea (“TJUE”) ha solicitado una modificación de su Estatuto para hacer frente a los retos derivados de una carga de trabajo cada vez mayor. El objetivo es redefinir la competencia de los órganos jurisdiccionales de la UE con el fin de permitirles seguir cumpliendo, en un plazo razonable, la misión que les han asignado los redactores de los Tratados en el artículo 19, apartado 1, del Tratado de la UE (“TUE”), a saber, garantizar que “en la interpretación y aplicación de los Tratados se respete el Derecho”. La reforma prevé concretamente una transferencia parcial de las competencias interpretativas al Tribunal General (“TG”), combinada con la facultad del TJUE de tratar asuntos de especial relevancia. Además, la posibilidad de interponer un recurso ante el TJUE se limitará si las salas de recurso de las agencias de la UE ya han llevado a cabo una revisión jurídica en primera instancia. Una serie de salvaguardias evitarán una situación en la que el reparto de la carga de trabajo por dos órganos jurisdiccionales distintos pueda tener un efecto negativo en la uniformidad y coherencia de la jurisprudencia.
FAMILY STORIES UNTOLD
Authors: Siim Pihla Maria
Published: May 2024

Family history can be seen to be comprised of both told and untold stories and sentiments related to them, all of which affect family members. Drawing on interviews conducted with immigrants from the former Soviet Union living in Finland and their family members living in the country of origin (in Russian Karelia and Estonia), this article explores the silenced aspects of family storytelling and analyses how the absence of narration can serve as a protector and maintainer of family as a set of relationships, or an enabler of “normal” family life. The focus of the article is on family past, and the continuum from tellable to silenced experiences will be analysed. However, the methodological side of studying unsaid or unsayable things is also touched upon.
Surgical management of cornual heterotopic using intraoperative sonography depth resection guidance: case report
Authors: Hagenow Allison , Shaffer Sarah A , Jain Surbhi C.
Published: May 2024

Heterotopic pregnancy is an uncommon phenomenon in which an ectopic and intrauterine pregnancy coexist. This condition can be life-threatening and poses a significant therapeutic challenge. Here we describe management of a heterotopic pregnancy with the ectopic pregnancy located in the right cornua. Resection of the ectopic pregnancy was performed via open laparotomy with intraoperative sonography. A sonography guided approach may optimize resection depth while secondarily allowing monitoring of the intrauterine pregnancy and prevention of disruption in cases in which the gestational sacs are in close proximity. After resection, the course of the pregnancy was uncomplicated, and a healthy baby was delivered via planned cesarean delivery at 36 weeks. While the optimal management of heterotopic pregnancies is often individualized, prompt diagnosis and treatment can result in favorable outcomes. The use of ultrasound intraoperatively allows for more precise resection depth, and which may lead to improved outcomes including increased intrauterine fetal survival rates and decreased myometrial scarring.
Treatment outcome of elderly patients (≥ 78 years) with head and neck squamous cell carcinoma: A single center experience
Authors: Liu Yi , Wang Dan , Deng Yue , Zhang Shichuan
Published: May 2024

Patients older than the expected age of the local population generally have limited life expectancy. The optimal treatment approach for very elderly patients with head and neck cancer remains uncertain. This study retrospectively analyzed patients over 78 years old, the expected age in 2019 for Chinese individuals, who underwent treatment for head and neck cancer at a tertiary cancer center in China. The study compared the overall survival rates among different treatment groups. The findings revealed that among patients eligible for surgery, radical resection yielded better outcomes compared to radiotherapy-based treatments, with a hazard ratio of 0.362 (95% CI 0.160-0.819, P = 0.015). Among patients who received radiotherapy, those who received a total dose exceeding 60 Gy had a significantly longer survival compared to those who received palliative doses, with median survival time of 31 months versus 14 months (P = 0.003). Among 78 patients who underwent conventional fractionated radiotherapy (CFRT), 15 patients (19.23%) experienced unscheduled treatment breaks with a median duration of 12 days. However, these treatment breaks did not appear to impact survival (P > 0.1). The study also suggested that altered fractionated radiotherapy, including hypofractionated radiotherapy (hypo-RT), could be a viable alternative to CFRT, offering similar survival outcomes with reduced treatment duration. In conclusion, eligible patients should be treated with curative intent, even if they are older than the expected age of the local population. When radiotherapy is indicated, altered fractionation, particularly hypo-RT, may be a favorable option to consider.
A sirtuin 6 activator in the pipeline: New perspectives in depressive disorder treatment
Authors: Ana Carolina de Oliveira Pereira , Gabriel Almeida Mendonça da Silva , José C. Barros , Raoni Schroeder Borges Gonçalves
Published: May 2024

Major Depressive Disorder (MDD) is among the most prevalent mental illnesses worldwide. Its symptoms include persistent feelings of sadness, loss of interest in previously enjoyed activities, and a lack of motivation for daily tasks. While FDA-approved medications are available, they often come with side effects, especially those targeting monoamine neurotransmitters like SSRIs and SNRIs. Thus, there is a need for innovative medications with different mechanisms of action. Sp-624, a derivative of griseofulvin, is currently undergoing clinical trials for MDD treatment. It acts as a sirtuin 6 (SIRT6) activator, offering a novel approach to treating this disorder. This article discusses the biochemical aspects related to the mechanism of action of sp-624, provides a brief overview of related patents, and highlights ongoing clinical trials involving this substance.
Sample preparation protocol for proteomic analysis of isolated lysosomes and whole cell extracts v1
Authors: Saarela Daniel
Published: May 2024

Mass spectrometry-based proteomics has emerged as fundamental technique to study functional changes of proteome including post translational modifications. Sample preparation is key for an effective and reproducible identification and quantification for proteomic analysis. Here, we describe a step wise protocol for samples derived from cell lines models or isolated human cells. The protocol has been optimised for organelle pulldown preps. To maximize proteomic coverage, we deploy a strong detergent (2% SDS), as well as high energy sonication to ensure complete solubilization of tissue/cellular proteins. We describe a facile protocol for straightforward capture of solubilized protein samples on a S-trap column that allows removal of SDS and other components that interfere with protease digestion. We provide an optimized trypsin/Lys-C protease digestion protocol to maximize protein digestion.
Agroforestry uygulamalarından olan rüzgâr perdelerinin tarımsal alanlarda kullanımı
Authors: Turna İbrahim , Atar Fahrettin , Güney Deniz , Turna Hülya
Published: May 2024

Türkiye’nin çeşitli ekolojik bölgelerinde, arazi kullanımının sürdürülebilirliği ve korunması amacıyla tarım, ormancılık, korunan alanlar ve yerleşim bölgeleri dengeli bir şekilde ele alınmalıdır. Özellikle küresel iklim değişikliği, çölleşme ve erozyon gibi sorunlarla mücadelede arazi kabiliyet sınıflarına dayalı agroforestry uygulamaları önemli bir rol oynamaktadır. Rüzgâr erozyonunun etkileri göz önüne alındığında, tarımsal faaliyet alanlarında rüzgâr perdelerinin kullanımı büyük önem taşımaktadır. Rüzgâr perdelerinin etkinliği, kurulum ilkelerinin (yükseklik, süreklilik, geçirgenlik, yön ve uzunluk gibi faktörlerin) birlikte değerlendirilmesine bağlıdır. Tüm bu unsurlar ele alınırken her yörenin kendine has özellikleri incelenmeli ve yöresellik kanuna bağlı olarak ekonomik, ekolojik ve sosyal faktörler tesis edilecek sahaya göre etüt edilerek uygulamalar yapılmalıdır. Ancak, bu uygulamaların etkin olabilmesi için bitki seçimi, kurulum teknikleri ve bakım gibi unsurların dikkatle ele alınması gerekmektedir. Tarımsal ormancılık uygulamalarının, özellikle rüzgâr perdelerinin tarımsal üretime çok yönlü katkı sağlaması ve iklim değişikliği senaryolarına karşı önleyici bir rol oynaması beklenmektedir. Bu nedenle, bölgeye özgü çalışmaların hızlandırılması ve devlet desteğinin artırılması gerekmektedir. Tarımsal faaliyetlerle uğraşan doğaseverlerin arazi kullanımında, dikenli tel çit, ahşap kazıklar ya da betonarme engeller yerine canlı rüzgâr perdelerini tercih etmesi, doğaya uyum ve biyolojik çeşitliliğe katkı vererek sürdürülebilir ekosistemlerin oluşmasına yardımcı olur.
Divisive Issues, Polarization, and Users’ Reactions on Facebook: Comparing Campaigning in Latin America
Authors: Fenoll Vicente , Gonçalves Isabella , Bene Márton
Published: May 2024

Economic, social, and health crises have shaken and polarized contemporary politics. An element fueling this polarization is the dissemination of divisive topics on social media platforms. While these polarizing social media tendencies are increasingly studied, research exploring digital political communication in South America remains scarce. This study aims to analyze the electoral campaigns in Brazil, Colombia, Chile, and Peru to define the features that trigger polarized emotional reactions on Facebook. The corpus comprises a sample of 2,930 posts published by candidates and political parties during the first round of the presidential elections held in these countries between 2021 and 2022. We hypothesize that users are more likely to react in a polarized way to content focused on divisive issues. In addition, we examine how these patterns differ across countries and the influence of the level of political polarization. Finally, the role played by party-level characteristics in the emotional reactions of users is also analyzed. By means of quantitative content analysis, these questions are addressed using multilevel negative binomial regressions to identify what predicts Love and Angry reactions. The bandwagon effect seems to work positively on users’ moods since the most popular political actors receive significantly more Love reactions, irrespective of the post’s subject. In more polarized countries, there is a tendency to react more negatively to certain divisive issues, generating greater visibility of these issues on social networks and thus promoting more polarization. These findings expand knowledge about the dynamics of digital political communication in the Global South.
Cognitive and Speech Development of Preschool Children, Conceived through Assisted Reproductive Technologies
Authors: Surkova K.L.
Published: May 2024

Objectives. The mental health of children conceived using assisted reproductive technologies (ART) is a growing concern for parents and professionals. With a maximum compliance with the conditions for using reproductive technologies, the birth of a healthy child is expected. But some children conceived through artificial insemination have developmental problems, speech and/or cognitive problems. A pilot study was conducted on the cognitive and speech development of children from 3 to 8 years old with the aim of a comparative analysis of children from induced pregnancy with children conceived naturally, to determine the possible impact of ART methods on children's health.

Methods. The cognitive and speech functions of 115 children aged 3 to 8 years were studied: 54 children from induced pregnancy were included in the experimental groups (EG 1 and EG 2) and 61 children from natural conception were included in the control groups (CG 1 and CG 2). The method of neuropsychological diagnostics of children of L.S. Tsvetkova and methods of speech therapy examination (assessment of the state of facial and articulatory muscles, breathing, prosodic speech, general speech development) were used. The results were processed through the qualitative and quantitative assessment of the correspondence of the child’s cognitive and speech development to normative ontogenesis.

Results. It has been determined that children conceived through ART have a high percentage of perinatal risk: 35% of children (n=54) conceived through ART have: mental disorders (autism, intellectual disability) and various speech disorders in 77% of cases, — which has a negative impact on the development of cognitive activity. In children conceived naturally (n=61), the percentage of disorders was lower: in 47% of cases, cognitive disorders were noted, and in 60% of children, speech disorders of mild to moderate severity were identified.

Conclusions. The hypothesis about the possible influence of the fertilization methods used, the characteristics of the procedure, the health status of the parents before conception, the course of the mother’s pregnancy and other prenatal factors on the occurrence of developmental disorders in children conceived through ART is supported. An interdisciplinary approach to organizing research will allow a comprehensive study of the developmental features of children from induced pregnancy and the timely identification of possible dysontogenetic risk factors.
Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood in Psychological Practice
Authors: Arintsina I.A. , Artamonova A.Y. , Kravchenko A.P. , Lotosh O.R. , Nasretdinova S.F.
Published: May 2024

Objectives. Data collection requires a structure and a consistent algorithm to create a common language for the team of professionals and to support the development of support programs. Work on the approbation of the possibilities of using the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (DC:0-5) in the comprehensive assessment of the development and condition of the child and his/her immediate environment was carried out.

Methods. Over a 12-month period, 48 families with children aged from one month to 4 years 10 months were referred to the Child and Family Mental Health Center “Opening Doors”. Expert assessment was conducted using DC:0-5 and the following methods: observation, assessment of child and close adult relationships; assessment of the emotional state and behavior of adults.

Results. The possibilities of using the DC:0-5 tool were demonstrated on the example of one case from the practice of the center’s specialists: a structured diagnostic report, written in a common language for the team of specialists, included a description of the assessment results in accordance with the algorithm of data collection and structuring of information: cultural aspects; conditions and factors of the child’s physical health; psychosocial and environmental stress factors; developmental competencies and the context of the child’s relationships with close adults. Biological and social risk and protective factors are identified. Risk factors on the part of the adult can be: a suppressed emotional state, difficulties in recognizing the emotional needs and signals of the child and an inappropriate response to them; on the part of the child — a restraint of activity and emotions. In the conclusion, the opinions of specialists about the possibility of clinical disorders in the child are given.

Conclusions. The data obtained with the use of DC:0-5 allows us to formulate the directions of the individual program of support for the child and family fully and clearly. At the next stage of work it is planned to continue the analysis, systematization and description of cases of classification application with the generalization of results.
From Riva-Rocci until Miocardial Intersticial Fibrosis: The Seven Errors Game in Arterial Hypertension -Misconceptions Review
Authors: Pinho Claudio , Pinho Eni
Published: May 2024

Knowledge of cardiac, renal and vascular injuries that occur in Arterial Hypertension has been known for a long time, however, their correlation with high blood pressure levels can only occur after the dissemination of the measure developed by Riva-Rocci and perfected by Korotkoff at the beginning of the 20th century. This correlation was initially imagined with false assumptions, which led not only to inertia but also to an opposition to the decrease in blood pressure levels that lasted around five decades. These false assumptions are named and analyzed. Even after the definition that the drop in blood pressure levels should be an obligatory part of the treatment of this condition, other erroneous understandings of this pathology have continued to occur until today. In this review, which covers the last one hundred and thirty years, we found, enumerated and analyzed seven of these errors based on the current knowledge we have gained on Arterial Hypertension and exposed their differences, simulating a game of seven errors.
How Broad Modal Fictionalism Can Survive Rosen’s Challenge
Authors: Puczyłowski Tomasz
Published: May 2024

Gideon Rosen described the difficulties faced by those who claim that statements about possible worlds cannot be literally true. According to his argument, if the truth of modal sentences could be explained by referring to the hypothesis of the plurality of possible worlds, which is a sort of fiction for modal irrealists, the position would have antinomic consequence. I argue that the advocate of broad modal fictionalism can avoid such a devastating conclusion. To that end, her position should be given in meta-language describing the necessary and sufficient conditions of accepting modal sentences as true in terms of fiction of possible worlds. I show that there is a coherent way of reading ‘it is accepted as true’ that allows one to maintain that the disjunction of two mutually contradictory propositions can be accepted without accepting either of them.
Emotional experiences in the context of religion and sport
Authors: Barnat Damian
Published: May 2024

The subject of this paper is the relationship between religion and sport. The aim of my considerations is to criticise the position presented by the American philosopher Eric Bain-Selbo, according to which sporting experiences may quite rightly be described as religious experiences. In the first part of the article, I reconstruct Wayne Proudfoot’s concept of religious experience that underlies Bain-Selbo’s analysis. I then discuss the research conducted by Bain-Selbo and the conclusions he draws from it. In the next part of the article, referring to Charles Taylor’s hermeneutical approach, I show that Proudfoot’s and Bain-Selbo’s methodology leads to a theoretically unjustified reductionism. I argue that an in-depth articulation of individual self-interpretation allows for an insight into the dynamics of sporting and religious experiences, and thus to see the differences that separate them. In the last part of the article, I invoke the considerations of William James, John Hick and Robert Roberts and try to show that, given the moral consequences of our experiences and their phenomenological description (intentionality), the experiences evoked by sport and religion can by no means be identified with each other.
Single-source procurement and the principle of competition in the public procurement law
Authors: Wiklański Bartłomiej
Published: May 2024

Niniejsze opracowanie dotyczy problematyki funkcjonowania trybu udzielania zamówienia publicznego z wolnej ręki w obecnym porządku prawnym pod kątem oceny jego zgodności z istotą zasady konkurencyjności. Głównym celem pracy jest weryfikacja tezy mówiącej o tym, że tryb zamówienia z wolnej ręki jako tryb zamówienia klasycznego jest trybem przeczącym istocie funkcjonowania zamówień publicznych.
W tym celu opracowanie podzielono na sześć podpunktów. We wprowadzeniu do rozważań zawarto krótką charakterystykę omawianego trybu udzielania zamówienia publicznego. Następnie przedstawiono tezę i antytezę związane z tematem rozważań. Kolejno przeprowadzono polemikę z przedstawioną we wstępie tezą i antytezą. Całość zaś zwieńczyło podsumowanie, w którym odniesiono się do poruszonych w artykule problemów. Metodologią badawczą zastosowaną w pracy była analiza literatury oraz orzecznictwa z zakresu zamówień publicznych, w szczególności zaś dotyczących trybu zamówienia z wolnej ręki. Przeprowadzona
analiza pozwoliła wskazać wiele problemów związanych z zachowaniem zasady konkurencyjności.
Effect of Foliar Application of Selected Plant Growth Regulators on Growth and Yield of Soybean [Glycine max (L.) Merrill]
Authors: Wavhale Milind Mahadev , Salve Uttam Shankarrao
Published: May 2024

Background: Soybean (Glycine max), a prized oilseed crop known for its nutritional richness, is the focus of a study aiming to boost production with minimal environmental impact. The research explores the application of plant growth regulators (PGRs), specifically Gibberellic Acid (GA3), Kinetin and Salicylic Acid, in field experiments during the kharif seasons of 2022 and 2023 in Beed, India. Methods: The study applied Gibberellic Acid (GA3), Kinetin and Salicylic Acid at different concentrations in field experiments. A comprehensive analysis of growth and yield attributes, including plant height, primary branches, Leaf Area Index (LAI), root nodules and Crop Growth Rate (CGR), was conducted to assess the influence of PGR treatments on soybean growth. Yield attributes such as pod count, pod weight, seed count per pod and 100-seed weight were scrutinized to understand their effects on soybean productivity. Result: The study highlighted significant effects of PGR treatments on soybean growth and yield. Notably, Kinetin at 500 ppm promoted the tallest plants, while GA3 at 200 ppm resulted in the shortest. Kinetin at 100 ppm increased primary branches and Salicylic Acid at 50 ppm exhibited the highest LAI and abundant root nodules. Kinetin at 500 ppm and Salicylic Acid at 50 ppm showed higher CGR, indicating efficient crop growth. For yield, Kinetin at 500 ppm excelled in pod count and weight. GA3 at 100 ppm was identified as the most effective PGR for enhancing various growth parameters and soybean seed yield, suggesting the potential of PGRs in sustainable cultivation, reducing reliance on chemical inputs.
Effect of Different Spacing Level and Growth Stages of Chekkurmanis (Sauropus androgynus L.) on Plant Growth
Authors: Naveena E. , Janavi G.J. , Rameshkumar D. , Fathima A. Fahima , Nivedha C.K.
Published: May 2024

Background: Chekkurmanis, is a shrubby glabrous perennial green leafy vegetable, extensively grown in warm humid tropics. It is called as “Multivitamin / Multigreen” plant. Micronutrient deficiency has spread all over the world and it is termed as “Hidden Hunger”. In this regard, chekkurmanis is the chief source of many minerals and nutrients is help to eradicate these deficiencies. The yield enhancement and improvement on plant growth characters could be manipulated by adopting optimized cultural practices, especially plant spacing and stage of harvest. With the background, present study was taken up to examine the variations in morphologically; under different spacing’s in relation to different growth stages were assessed and discussed. Methods: The research study was carried during 2019-2020. The healthy rooted cuttings collected from Orchard, Agricultural College and Research Institute, Madurai, Tamil Nadu. The research trial consisted of two factors different spacing’s (Factor I) and specific days interval (Factor II). Result: Based on the results, it can be suggested that growth characters i.e. plant height, number of branches, number of leaves per plant and petiole length parameters were significantly higher under closer spacing at 180 days after planting (S1D3). While, Maximum leaf length, leaf breadth and plant spread were recorded under wider spacing at 180 days after planting (S5D3).
Plasma-chemical synthesis of carbide-based vacuum-plasma functional coatings and study of tribological characteristics of friction pairs
Authors: Sagalovych Alex , Sagalovych Vladislav , Popov Victor , Dudnik Stanislav
Published: May 2024

The work is devoted to the search for new materials with high functional characteristics using the Avinit vacuum-plasma technologies developed by us, based on the complex use of coating methods (plasma-chemical CVD, vacuum-plasma PVD (vacuum-arc, magnetron), processes of ion saturation and ion surface treatment), stimulated by non-equilibrium low-temperature plasma.Processes of controlled plasma-chemical synthesis of the formation of multicomponent coatings in "metal-carbon" systems – Avinit coating (TiC, MoC) using vacuum-arc sources of ionized atomic fluxes of titanium and molybdenum in an argon-benzene plasma environment were developed and their characteristics were studied depending on their conditions formation.Metallographic studies confirm the possibility of low-temperature application of high-quality wear-resistant high-hard "metal-carbon" coatings with a hardness of 18,000-30,000 MPa, while ensuring good adhesion to the substrate materials (steel DIN 1.2379) without reducing strength and without deteriorating the cleanliness class of the original surface.The conducted tribological tests using the "cube-roller" scheme reveal high tribological characteristics of steel DIN 1.2379 tribopairs with developed coatings and testify to the promisingness of the developed multi-component multilayer coatings Avinit (Ti-C, MoS) for increasing wear resistance and reducing the coefficient of sliding friction in friction nodes.The developed plasma-chemical vacuum-plasma coatings are applied to mock-up samples of the working compressor blades of the GTE of aircraft engines. Proven modes allow to get high-quality, uniform coatings with high adhesion.This gives reason to consider the developed process as an alternative for expanding the range of new Avinit vacuum-plasma erosion-resistant coatings and developing structures of anti-friction wear-resistant coatings to increase the performance of friction pairs in "coating-steel" and "coating-coating" systems.
Functional reliability of means of fixation for complex pelvic fractures. Part 1: Materials and methods
Authors: Dyman Marianna , Shydlovskyi Mykola , Bobyr Mykola , Laksha Andriy , Fomin Oleksandr
Published: May 2024

Due to the military aggression of the Russian Federation against Ukraine, a large number of soldiers and civilians were wounded and injured. Along with fractures of the long bones of the limbs, skull injuries, limb amputations, the number of injuries in the pelvic area with fractures of the pelvic bones as a result of being hit by high-velocity projectiles (shrapnel, bullets) has increased.This work is devoted to the preparation and research of the characteristics of stiffness and reliability of fixation of complex fractures of the pelvic bones in the area of the sacroiliac joint and the upper and lower branches of the pubic bone, which may occur as a result of injury by high-velocity projectiles that injure.The sacroiliac area was fixed with two cancellous screws with a parallel arrangement at the intersection of the horizontal and vertical planes (a typical technique for stabilizing the posterior parts of the pelvis). The anterior parts of the pelvic bones were stabilized with rod devices of external fixation with a typical location of the rods in the upper anterior iliac spine. The upper branch of the pubic bone was synthesized with a bony reconstructive plate with a typical location.
Finding and analyzing of the energy and force parameters of the flange formation process by orbital stamping by rolling
Authors: Li Qiang , Uzunov Oleksandr
Published: May 2024

The study was carried out based on the developed mathematical model of the discrete hydraulic actuator. The model is characterized by considering the nonlinear friction based on the LuGre model, the bidirectional motion of the asymmetric hydraulic cylinder, and the elastic properties of the fluid. A series of simulation experiments on the braking process of the hydraulic actuator in the discrete control mode were carried out. The quantitative relationship between the rod braking time, the maximum peak pressure in the hydraulic cylinder chambers, the value of the initial rod velocity and the inertial mass of the moving parts are determined. Based on the research results it is possible to predict the braking time of the rod and the maximum peak pressure in the hydraulic cylinder chambers under various operating conditions and inertial loads. These predictions can be used in the settings and design process of hydraulic actuators.
Predictors of Speech-in-Noise Understanding in a Population of Occupationally Noise-Exposed Individuals
Authors: Andéol Guillaume , Paraouty Nihaad , Giraudet Fabrice , Wallaert Nicolas , Isnard Vincent , Moulin Annie , Suied Clara
Published: May 2024

Understanding speech in noise is particularly difficult for individuals occupationally exposed to noise due to a to a mix between noise-induced auditory lesions and energetic masking of speech signal. For years, the monitoring of conventional audiometric thresholds has been the usual way to check and preserve the auditory function. But the highlighting of supra-threshold deficits, notably speech in noise understanding difficulties, has pointed out the need for new monitoring tools. The present study aims to identify the most important variables that predict speech in noise under-standing in order to suggest a new way of regular monitoring. Physiological (distortion products of otoacoustic emissions, electrocochleography) and behavioral (amplitude and frequency modula-tion detection thresholds, conventional and extended high frequency audiometric thresholds) variables were collected in a population of individuals presenting a relative homogeneous occu-pational noise exposure. Those variables were used as predictors in a statistical model (random forest) to predict scores of three different speech in noise tests and a self-report of speech in noise ability. The extended high frequency threshold appears to be the best predictor and therefore an interesting candidate for a new way of monitoring noise exposed professionals.
Iron Metabolism in the Recovery Phase of Critical Illness
Authors: Zhang Xiyang , Holbein Bruce , Zhou Juan , Lehmann Christian
Published: May 2024

Iron is an essential nutrient for humans and microbes, such as bacteria. Iron deficiency occurs commonly in critically ill patients, but iron replacement therapy is not considered during the acute phase of critical illness, since it increases iron availability for invading microbes and oxidative stress. However, persistent iron deficiency in the recovery phase is harmful with potential adverse outcomes such as cognitive dysfunction, fatigue and cardiopulmonary dysfunction. Therefore, it is important to treat iron deficiency timely and efficiently. This article reviews current knowledge about iron-related biomarkers in critically ill patients and provides possible criteria to guide decision-making for iron supplementation in the recovery phase of critical illness.
Restoring University of Lagos’s Campus Wetlands and Green Corridors: Sustainable Ecotourism and Landscape Design Approach
Authors: Adesina John Adekunle , Tang Xiaolan , Ren Yujie
Published: May 2024

Teaching, learning, research, and development are all supported in a favorable atmosphere at the University of Lagos (UNILAG). The wetland systems made up of freshwater that are extremely biodiverse makeup about 10% of the total land area. Flooding, deforestation, excessive sedimentation, blockages to streams, abuse, overuse, and invasion of wetlands are some of the recent environmental challenges that the university faced. Urban heat island impacts, contaminants in the air, wetland degradation, social issues including stress, and a detachment from nature are all major concerns. With the green corridor behind the faculties of law and management science serving as a model supported by sustainability as a true foundation for UNILAG's campus landscapes, this article investigates the sustainable restoration of wetlands within the boundaries of the university. The use of qualitative techniques was employed, utilizing the Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis. Additionally, a geospatial mapping of the wetlands and tributaries that connect the Lagos Lagoon was conducted to evaluate the intrinsic ecological goods and services through a series of analytical steps, beginning with an analysis of the land area, current biodiversity, hydrology, and its potential through landscape mapping and analysis. The biophysical setup, landscape features, climatic data analysis, the ecological goods and services derived from the wetlands, and the records of flooding and rainfall are all included in the geospatial evaluation and analysis. The educational institution's site planning for the remediation of its wetlands takes into account the actual evolution of the area's drainage network. Throughout the wetlands, low carbon emissions are generated by off-road bike lanes, trails for walking, and raised hardwood platforms. Combining native plant species and park furniture, the academic landscape atmosphere will be improved in each of the wetlands and aesthetic values. the country's "University of First Choice" and its biophysically restored wetlands will help illuminate the landscape while the green corridors have an innate ability to attract human affinity within the academic community. All of these elements are implemented following an environmentally friendly landscape planning, management, design model, and enforcement process.
The Investigation of the Synthesis, Characterization, Molecular Docking, and Pharmacokinetic Properties of New Thiocarbohydrazones Based on Schiff Bases
Authors: Turkoz Karakullukcu Nalan
Published: May 2024

Ten new Schiff bases, including thiocarbohydrazone derivatives (1–10), were synthesized using an efficient, uncomplicated, and environmentally friendly approach using the reaction of alkyl-substituted aldehydes. The thiocarbohydrazones that were obtained were derived from o-phthalaldehyde. The chemical structures of the compounds were identified by the utilization of UV-Vis spectroscopy, Fourier transform infrared (FT-IR), 1H nuclear magnetic resonance (1H NMR), 13C nuclear magnetic resonance (13C NMR), and elemental analysis methods. The thermal stability of thiocarbohydrazones was examined using thermogravimetric analysis (TGA-DSC). Investigations were conducted on urease inhibition tests, pharmacokinetic property research, and molecular docking. The collection of samples with the urease enzyme revealed significant molecular docking findings, with MolDock scores ranging from -153 to -189. The compounds have the potential to be effective drug candidates for treating certain diseases, as indicated by the consistent results of molecular docking, urease inhibition tests, and pharmacokinetic characteristics investigations.
The Use of Broadly Neutralizing Antibodies (bNAbs) in HIV-1 Treatment and Prevention
Authors: Thavarajah Jannifer Jasmin , Hønge Bo Langhoff , Wejse Christian Morberg
Published: May 2024

Background: Although antiretroviral therapy (ART) effectively halt disease progression in HIV infections, complete eradiation of the virus remains elusive. Additionally, challenges such as long-term ART toxicity, drug resistance, and the demanding regimen of daily and lifelong ad-herence required by ART highlight the imperative need for alternative therapeutic and preventa-tive approaches. In recent years, broadly neutralizing antibodies (bNAbs) have emerged as promising candidates, offering potential for therapeutic, preventative and possibly curative in-terventions against HIV infection.
Objective: This review aims to provide a comprehensive overview of the current state of knowledge regarding the passive immunization of bNAbs in HIV-1 infected individuals.
Main findings: Recent findings from clinical trials have highlighted the potential of bNAbs in treatment, prevention, and in the quest of an HIV-1 cure. While monotherapy with a single bNAb is insufficient in maintaining viral suppression and preventing viral escape, ultimately leading to viral rebound, combination therapy with potent, non-overlapping epitope-targeting bNAbs have demonstrated prolonged viral suppression and delayed time to rebound by effec-tively restricting the emergence of escape mutations, albeit largely in individuals with bNAb-sensitive strains. Additionally, passive immunization of bNAb have provided ‘proof-of-concept’ for antibody-mediated prevention against HIV-1 acquisition, although com-plete prevention was not obtained. Therefore, further research on the use of bNAbs in HIV-1 treatment and prevention remains imperative.
Neurofibromatosis Type 2 (NF2): Molecular Insights and Therapeutic Avenues
Authors: Kim Bae-Hoon , Chung Yeon-Ho , Woo Tae-Gyun , Kang So-mi , Park Soyoung , Kim Minju , Park Bum-Joon
Published: May 2024

Neurofibromatosis type 2 (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, particularly bilateral vestibular schwannomas, meningiomas, and ependymomas. This review consolidates the current knowledge on NF2 syndrome, emphasizing the molecular pathology associated with the mutations in the gene of the same name, the NF2 gene, and the subsequent dysfunction of its product, the Merlin protein. Merlin, a tumor suppressor, integrates multiple signaling pathways that regulate cell contact, proliferation, and motility, thereby influencing tumor growth. The loss of Merlin disrupts these pathways, leading to tumorigenesis. We discuss the roles of another two proteins potentially associated with NF2-deficiency as well as Merlin: Yes-associated protein 1 (YAP), which may promote tumor growth, and Raf kinase inhibitory protein (RKIP), which appears to suppress tumor development. Additionally, this review discusses the efficacy of various treatments, such as molecular therapies that target specific pathways or inhibit neomorphic protein-protein interaction caused by NF2-deficiency. This overview not only expands on the fundamental understanding of NF2 pathophysiology but also explores the potential of novel therapeutic targets that affect the clinical approach to NF2 syndrome.
Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis
Authors: VIALAT Marine , BAABDATY Elissa , TROUSSON Amalia , KOCER Ayhan , LOBACCARO Jean-Marc A. , BARON Silvère , MOREL Laurent , de JOUSSINEAU Cyrille
Published: May 2024

Epidemiological studies point cholesterol as a possible key factor for both prostate cancer incidence and progression. So, it could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies designed to decrease hypercholesterolemia, such as statins. However, whether and how cholesterol, through its dietary uptake and its metabolism, could be important for early tumorigenesis, remains unknown. Oncogene clonal induction in Drosophila melanogaster accessory gland allows to reproduce tumorigenesis from initiation to early progression, where tumour cells undergo basal extrusion to form extra-epithelial tumors. Here we show that these tumors accumulate lipids, and especially esterified cholesterol, as in human late carcinogenesis. Interestingly, high cholesterol diet displays limited effect on accessory gland tumorigenesis. On the contrary, cell-specific downregulation of cholesterol uptake, intracellular transport or metabolic response, impairs the formation of such tumors. Furthermore, in this context, high cholesterol diet suppresses this impairment. Taken together, these results reveal that during early tumorigenesis, tumour cells strongly increase their uptake and use of dietary cholesterol to specifically promote the step of basal extrusion. Interestingly, expression data from primary prostate cancer tissues indicate an early signature of redirection from cholesterol de novo synthesis to uptake. Altogether, these results suggest by which mechanism reduction of dietary cholesterol could lower the risk and slow down the progression of prostate cancer.
Camel Milk Processing Opportunities: A Review
Authors: Issimov Arman
Published: May 2024

Camel milk occupies a pivotal and essential position in the dietary customs of individuals residing in semi-arid and arid areas. Historically, the promotion and distribution of camel milk have been negligible, primarily due to the absence of processing facilities in areas where camels are raised. Consequently, the consumption of untreated camel milk has been predominantly limited to nomadic households. However, owing to its exceptional medicinal properties and health-enhancing effects, a substantial surge in the global demand for camel milk and its derivatives has been observed over the past two decades. This growing demand has prompted the dairy sector to introduce a diverse range of camel milk products, which are distinguished by their enhanced nutritional and functional properties. In contrast to products derived from bovine milk, the current market offers only a limited selection of food items sourced from camel milk.
Recent advances in food processing technologies have enabled the production of an array of both dairy and non-dairy products derived from camel milk. This includes a variety of items such as powdered milk, cheese, yogurt, ice cream. Moreover, in certain regions, camel milk is incorporated into customary cuisine, serving as a key ingredient in local culinary practices like fermented milk, camel milk tea, or as a fundamental component in various meals. This review underscores the possibility of transforming camel milk into a range of dairy products by addressing its intrinsic functional constraints. This objective can be realized by adjusting the processing parameters and modifying its chemical composition through enrichment techniques. Furthermore, further research avenues may focus on enhancing product quality and exploring innovative processing techniques.
Assessing Industrial Past and Cultural Change over Industrial Lands along Hangzhou Section of Chinese Grand Canal
Authors: CAO Furan , Zhu Bin , Huang Lingyan , Liu Chao
Published: May 2024

Few studies have paid attention to the industrial lands along the Chinese Grand Canal from a cultural per-spective, but cities along the route like Hangzhou have relied on the Canal system to promote industrializa-tion over the past hundred years, and relocated, transformed, or demolished the factories to construct cul-tural space or products mostly after industrial recession at the beginning of 21st century. To deeply analyze this process is quite helpful to understand the typical cultural change and its gain and loss along the Canal especially after cultural and creative industries have been established as the pillar industries of China's na-tional economy. Therefore, along the Hangzhou section of the Canal, we dynamically monitored the land use of the selected 10 industrial lands, with the analysis of high-resolution satellite imageries and the in-dustrial past, the areas of different uses in 2022 were compared. Meanwhile, along with archival data, fieldwork, and experts’ consultation, we designed a mark sheet with factors and scores to comprehensively assess cultural changes over those lands, and its reasons and influence also have been argued, and the prob-lems and suggestions have been offered. This study can contribute to a better understanding of public poli-cy choices in China regarding cities along the Grand Canal after the industrial decline, and provide new perspectives for cultural research, heritage conservation, and urban planning of canals or waterfront spaces.
Predictive Analytics Performance on Oil and Gas: A Significant Review
Authors: R Azmi Putri Azmira , Yusoff Marina , Mohd Salledud-din Mohamad Taufik
Published: May 2024

Enhancing the management and monitoring of oil and gas processes demands developing precise predictive analytics techniques. Over the past two years, oil and its prediction have advanced significantly using conventional and modern Machine Learning techniques. Several review articles detail the developments in predictive maintenance and technical and non-technical aspects of influencing the uptake of big data. The absence of references for machine learning techniques impacts the effective optimization of predictive analytics in the oil and gas sector. This review paper offers readers thorough information on the latest machine learning methods utilized in this industry's predictive analytical modelling. The review covers forms of Machine Learning techniques used in predictive analytic modelling from 2021 to 2023 (91 articles). It provides an overview of the details of the papers that were reviewed, comprising of the model’s categories, the data's temporality, field, and name, the dataset's type, predictive analytics (classification or clustering or prediction), the models' input and output parameters, performance metrics, optimal model, and benefits and its drawbacks. Additionally, suggestions for future research directions are provided to raise the potential of the associated knowledge and increase the accuracy of oil and gas predictive analytics models.
Unveiling the Potential of Cryogenic Post-Combustion Carbon Capture: From Fundamentals to Innovative Processes
Authors: Luberti Mauro , Ballini Erika , Capocelli Mauro
Published: May 2024

: Climate change necessitates urgent actions to mitigate carbon dioxide (CO2) emissions from fossil fuel-based energy generation. Among various strategies, the deployment of carbon capture and storage (CCS) solutions are critical for reducing emissions from point sources such as power plants and heavy industries. In this context, cryogenic carbon capture (CCC) via desublimation has emerged as a promising technology. While CCC offers high separation efficiency, minimal downstream compression work, and integration potential with existing industrial processes, challenges such as low operating temperatures and equipment costs persist. Ongoing research aims to address these hurdles in order to optimize the desublimation processes for widespread implementation. This review consolidates diverse literature works, providing insights into the strengths and limitations of CCC technology, including the latest pilot plant scale demonstrations. The transformative potential of CCC is first assessed on a theoretical basis, such as thermodynamic aspects and mass transfer phenomena. Then, recent advancements in the proposed process configurations are critically assessed and compared through key performance indicators. Furthermore, future research directions for this technology are clearly highlighted.