bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengthening urban deer management with structured decision making
Authors: Boehne Shane D. , Bynum Boley B. , Van Buskirk Amanda N. , Goode Kaitlin O. , Killmaster Charlie H. , Johannsen Kristina L. , D'Angelo Gino J.
Published: October 2024

Urban deer management (UDM) decision‐makers face social, ecological, regulatory, and economic pressures when creating an agreeable deer management plan for stakeholders. Historically, decision making techniques (e.g. consensus‐based analyses) have not effectively balanced UDM elements leading to short‐lived management progress. Structured decision making (SDM) is a formal, values‐based approach to identifying an optimal management solution. Although SDM has been applied to other wildlife management decisions, it has not been applied in UDM. We provide the first case‐study of SDM‐based UDM and streamline the process for wildlife managers. We focused on one suburban and one semi‐rural community near Atlanta, Georgia, USA. We established a problem statement to capture what decision‐makers must address in UDM programs and reviewed the primary literature and UDM plans from five states to establish four fundamental objectives. We then utilized a support–effectiveness analysis to identify acceptable UDM alternatives and gathered expert insights to calculate the consequences of alternatives on objectives. Finally, we asked each community's decision‐makers to weigh objectives against each other. Using this framework, education was the most optimal UDM technique to implement in the suburban community, and sharpshooting was the most optimal UDM technique to implement in the semi‐rural community. This paper positions SDM as a transparent, defensible, inclusive, and adaptive approach to UDM. Furthermore, our SDM framework provides managers with the means and justification to create an optimal plan of action for communities in need of UDM.
Introduction
Authors: Viret Olivier , Gindro Katia
Published: October 2024

Domesticated from wild lianas growing in trees, grapevine (Vitis vinifera subsp. vinifera) has been cultivated for over 11,000 years. From its original habitat to its establishment in the steeply sloping regions of Europe to create picturesque landscapes and terraces, to the methodically aligned rows of modern industrial vineyards, the vine has passed through several stages of natural or human-influenced co-evolution. Growers have gradually dispersed grapevine from its genetic centre in the Caucasus and Western Asia throughout Europe and to the rest of the world. Documentation on vine cultivation before the eighteenth century is sparse, particularly regarding diseases and pests which were increasingly discovered through microscopic observation and better understood as they became ubiquitous and increasingly destructive. The European phylloxera crisis at the end of the nineteenth century had disastrous economic consequences and led to radical changes in vine growing. Generations of researchers worked diligently to discover, understand and defeat fungi. Even with regular applications of effective fungicides, pathogen control remains a challenge in all the world’s vine-growing areas. Depending on weather conditions, both Vitis species that are highly susceptible (V. vinifera) and partially resistant (Vitis spp) contend with fungal diseases. The science of fungi in grapevine focuses on the complexity of this group of pathogens, their interactions with the host plant, the structure and anatomy of the grapevine, the plant’s defence mechanisms and resistance genes, the role of fungicides and alternative plant protection products, and the importance of spraying technologies for disease management.
Definitorische und inhaltliche Grundlagen
Authors: Massimiani Andrea
Published: October 2024

Ziel dieses Kapitels ist es, ein für die Dissertation relevantes Grundverständnis des Forschungsfeldes zu erarbeiten.
Kritische Bestandsaufnahme zum State-of-the-Art des Untersuchungsgegenstandes
Authors: Massimiani Andrea
Published: October 2024

Das Hauptziel dieses Kapitels besteht darin, relevante Veröffentlichungen für die vorliegende Arbeit zu sammeln und zu interpretieren. Die daraus erhaltenen und überprüften Erkenntnisse liefern auf der einen Seite einen Beitrag zum Theoriebildungsprozess, der dazu führt, in Abschnitt 4.2 und 4.3 die Forschungslücke sowie die Abgrenzung des Untersuchungsgegenstandes zu begründen, und darauf aufbauend auf der anderen Seite den konzeptionellen Bezugsrahmen im fünften Kapitel zu entwickeln.
Asymptotics of Solutions to Silent Wave Equations
Authors: Franco Grisales Andrés
Published: October 2024

We study the asymptotics of solutions to a particular class of systems of linear wave equations, namely, of silent equations. Here, the asymptotics refer to the behavior of the solutions near a cosmological singularity, or near infinity in the expanding direction. Leading-order asymptotics for solutions of silent equations were already obtained by Ringström (Astérisque 420, 2020). Here, we improve upon Ringström’s result, by obtaining asymptotic estimates of all orders for the solutions, and showing that solutions are uniquely determined by the asymptotic data contained in the estimates. As an application, we then study solutions to the source free Maxwell’s equations in Kasner spacetimes near the initial singularity. Our results allow us to obtain an asymptotic expansion for the potential of the electromagnetic field, and to show that the energy density of generic solutions blows up along generic timelike geodesics when approaching the singularity. The asymptotics we study correspond to the heuristics of the BKL conjecture, where the coefficients of the spatial derivative terms of the equations are expected to be small, and thus these terms are neglected in order to obtain the asymptotics.
Exposure to antibiotics and risk of latent autoimmune diabetes in adults and type 2 diabetes: results from a Swedish case–control study (ESTRID) and the Norwegian HUNT study
Authors: Edstorp Jessica , Rossides Marios , Ahlqvist Emma , Alfredsson Lars , Askling Johan , Di Giuseppe Daniela , Grill Valdemar , Sorgjerd Elin P. , Tuomi Tiinamaija , Åsvold Bjørn O. , Carlsson Sofia
Published: October 2024

Aims/hypothesis

Some studies find an increased risk of type 1 diabetes in children exposed to antibiotics. We investigated if exposure to antibiotics increases the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes.

Methods

We used data from a Swedish case–control study (Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes [ESTRID]: LADA, n=597; type 2 diabetes, n=2065; control participants matched on participation time, n=2386) and a case–control study nested within the Norwegian Trøndelag Health Study (HUNT) (n=82/1279/2050). Anatomical Therapeutic Chemical (ATC) codes indicating antibiotic dispensations were retrieved from the Swedish National Prescribed Drug Register and Norwegian Prescription Database. Multivariable adjusted ORs with 95% CIs were estimated by conditional logistic regression and pooled using fixed-effects inverse-variance weighting.

Results

We observed no increased risk of LADA with exposure to antibiotics up to 1 year (ORpooled 1.15, 95% CI 0.93, 1.41) or 1–5 years (ORpooled 0.98, 95% CI 0.80, 1.20) prior to diagnosis/matching for one or more vs no dispensation of any type of antibiotic. An increased risk was observed for one or more vs no dispensations of narrow-spectrum antibiotics, but not broad-spectrum antibiotics, 6–10 years prior to LADA diagnosis (ORpooled 1.39, 95% CI 1.01, 1.91), which was driven by the Swedish data. There was little evidence of an increased risk of type 2 diabetes associated with antibiotic exposure 1–10 years prior to diagnosis.

Conclusions/interpretation

We found no evidence that exposure to broad-spectrum antibiotics up to 10 years prior to diagnosis increases the risk of LADA. There was some indication of increased LADA risk with exposure to narrow-spectrum antibiotics, which warrants further investigation.

Graphical Abstract
Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults
Authors: Santoso Cornelia , Wei Yuxia , Ahlqvist Emma , Tuomi Tiinamaija , Carlsson Sofia
Published: October 2024

Aims/hypothesis

The aim of this study was to clarify the impact of autoimmune disease (AD) comorbidity on the risk and prognosis of latent autoimmune diabetes in adults (LADA).

Methods

We used data from a Swedish study comprising newly diagnosed cases of LADA (n=586, stratified into LADAlow and LADAhigh by autoantibody levels), type 2 diabetes (n=2003) and matched control participants (n=2355). Information on 33 ADs and diabetic retinopathy was obtained by linkage to regional and national registers. We estimated the ORs for LADA and type 2 diabetes in relation to ADs before diabetes diagnosis, and the HRs for diabetic retinopathy after diabetes diagnosis. We performed functional pathway analyses to explore biological mechanisms driving the associations.

Results

Individuals with ADs exhibit an increased susceptibility to LADA (OR 1.70; 95% CI 1.36, 2.13), particularly those with thyroid dysfunction (OR 1.88; 95% CI 1.38, 2.56), inflammatory bowel disease (OR 1.78; 95% CI 1.00, 3.16) or vitiligo (OR 3.91; 95% CI 1.93, 7.94), with stronger associations being observed for the LADAhigh phenotype. Only psoriasis was linked to type 2 diabetes (OR 1.47; 95% CI 1.08, 1.99). The biological pathways shared by LADA and ADs revolved around immune responses, including innate and adaptive immune pathways. The HRs for diabetic retinopathy in LADA patients with and without AD vs those with type 2 diabetes were 2.11 (95% CI 1.34, 3.32) and 1.68 (95% CI 1.15, 2.45), respectively.

Conclusions/interpretation

We confirm that several common ADs confer an excess risk of LADA, especially LADA with higher GADA levels, but having such a comorbidity does not appear to affect the risk of diabetic retinopathy.

Graphical Abstract
Sparsified simultaneous confidence intervals for high-dimensional linear models
Authors: Zhu Xiaorui , Qin Yichen , Wang Peng
Published: October 2024

Statistical inference of the high-dimensional regression coefficients is challenging because the uncertainty introduced by the model selection procedure is hard to account for. Currently, the inference of the model and the inference of the coefficients are separately sought. A critical question remains unsettled; that is, is it possible to embed the inference of the model into the simultaneous inference of the coefficients? If so, then how to properly design a simultaneous inference tool with desired properties? To this end, we propose a notion of simultaneous confidence intervals called the sparsified simultaneous confidence intervals (SSCI). Our intervals are sparse in the sense that some of the intervals’ upper and lower bounds are shrunken to zero (i.e., [0, 0]), indicating the unimportance of the corresponding covariates. These covariates should be excluded from the final model. The rest of the intervals, either containing zero (e.g.,$$[-1,1]$$[-1,1]or [0, 1]) or not containing zero (e.g., [2, 3]), indicate the plausible and significant covariates, respectively. The SSCI intuitively suggests a lower-bound model with significant covariates only and an upper-bound model with plausible and significant covariates. The proposed method can be coupled with various selection procedures, making it ideal for comparing their uncertainty. For the proposed method, we establish desirable asymptotic properties, develop intuitive graphical tools for visualization, and justify its superior performance through simulation and real data analysis.
Gately values of cooperative games
Authors: Gilles Robert P. , Mallozzi Lina
Published: October 2024

We investigate Gately’s solution concept for cooperative games with transferable utilities. Gately’s conception introduced a bargaining solution that minimises the maximal quantified “propensity to disrupt” the negotiation process of the players over the allocation of the generated collective payoffs. We show that Gately’s solution concept is well-defined for a broad class of games and that it can be interpreted as a compromise solution. We also consider a generalisation based on a parameter-based quantification of the propensity to disrupt. We provide an axiomatic characterisation of the original Gately value as well as these generalised Gately values. Furthermore, we investigate the relationship of these Gately values with the Core and the Nucleolus and show that Gately’s solution is in the Core for all regular 3-player games, but is fundamentally different from the Nucleolus. We identify exact conditions under which these Gately values are Core imputations for arbitrary regular cooperative games. Finally, we investigate the relationship of the Gately value with the Shapley value.
Differential responses in recovery, growth and survival between intertidal and subtidal corals after acute thermal stress
Authors: Almeida L. P. , Osinga R. , Knoester E. G.
Published: October 2024

Sea temperature increases may compromise ecological restoration as a tool for recovering degraded coral reefs. A potential solution may lay within using corals with naturally higher thermal resilience, such as intertidal corals. This study aimed at comparing thermal resilience, growth and survival between intertidal and subtidal corals in a reciprocal transplant experiment. Sixty coral nurseries were installed in a shallow coral reef area in Kenya: half were placed in the intertidal zone and half in the subtidal zone. At both zones, intertidal and subtidal Pocillopora cf. damicornis coral fragments were cultured in equal proportions, resulting in 15 replicate nurseries for four treatments. After an initial culture phase of 1 month in situ, six nurseries per treatment were thermally stressed ex situ by exposing corals for 5 days to a temperature of 32 °C (3 °C above summer maximum), after which they were returned in situ to recover. Fragment brightness was measured as the response variable to thermal stress. Intertidal and subtidal corals increased brightness (i.e., bleached) at a similar rate, but during recovery intertidal corals returned quicker to their original brightness in both culture environments. Coral growth was highest for intertidal corals in the intertidal zone during cooler months and was highest for subtidal corals in the subtidal zone during peak temperatures. Intertidal corals transplanted to the subtidal zone registered the lowest survival. Thus, intertidal corals display higher thermal resilience through quicker recovery, but potential trade-offs require further investigation before these corals can be used as a climate-proof broodstock for reef restoration.
Neonatal Brain MRI: Periventricular Germinal Matrix Mimicking Hypoxic-ischemic White Matter Injuries
Authors: Segev Maria , Sobeh Tamer , Hadi Efrat , Hoffmann Chen , Shrot Shai
Published: October 2024

Purpose

As pregnancy progresses, the germinal matrix volume decreases. Residual periventricular germinal matrix may be mistaken for hypoxic-ischemic white matter injury. This study aims to determine the prevalence and imaging characteristics of these findings.

Methods

This retrospective study analyzed brain MRIs of newborns from 2012–2023, performed within the first week of life. MRIs were done for suspected hypoxic-ischemic injuries, post-natal neurological symptoms, and evaluation of prenatally diagnosed structural anomalies. Image analysis targeted the remnants of the frontal periventricular germinal matrix, assessing its imaging characteristics, including diffusion, T1, and T2 signal characteristics, and laterality. Frontal migrating cell bands were also assessed.

Results

Seventy newborns were included (mean gestational age at delivery was 38.3 ± 2.1 weeks, mean scan age 5.1 ± 1.9 days). Frontal periventricular gray matter was detected in 39 newborns (90% bilateral) on T2-weighted images, negatively correlated with gestational age (r = -0.31, p = 0.013); none showed decreased ADC or shortened T1 signal compared with the basal ganglia. Frontal periventricular bands were found in 37 newborns (97.3% bilateral), strongly correlating with periventricular gray matter (r = 0.71, p < 0.001). No correlation was found between clinical hypoxic-ischemic injuries and these features.

Conclusion

The presence of frontal periventricular gray matter observed in early neonatal MRIs, without decreased ADC values or shortened T1 signal, is developmental, reflecting a late maturation phase. Careful interpretation of MRI characteristics, including diffusion, T1, and T2 signal intensities, is necessary before attributing these findings to hypoxic-ischemic white matter injury.
Temporal development of subdural collections in infants with confessed abusive head trauma: a forensic neuroimaging study
Authors: Hahnemann Maria , Karger Bernd , Radbruch Alexander , Mentzel Hans-Joachim , Wittschieber Daniel
Published: October 2024

Objectives

Estimating the age of injury in pediatric abusive head trauma (AHT) is a challenging task but potentially valuable for the identification of perpetrators. The aims of the study are (1) to describe the temporal development of different imaging features of subdural collections (SDCs), and (2) to provide novel age-diagnostic reference data for forensic-radiological expert reports.

Methods

Using a multi-center approach and a 10-year study period, serial neuroimaging studies of 13 comprehensively investigated AHT cases (8 CT and 26 MRI scans) were analyzed regarding several subdural imaging parameters (SDC appearances, entities, components, and associated findings). Due to confessions by perpetrators, the time points of the trauma were presumed unique and known in all cases facilitating correlation of imaging findings with time.

Results

Hyperdense SDCs in CT were found up to 9 d post-injury (p.i.), CSF-like SDCs in CT or MRI as early as from the 3rd hour p.i., and subdural membrane formation as late as from day 283. The heterogeneous variant of the subdural hematohygroma was observed to be the dominant SDC entity between 3 h and 22 d p.i. The tadpole sign was detected in MRI between 3 h and 46 d p.i.

Conclusion

Certain subdural imaging findings may be helpful for estimating the age of injury in AHT. Subdural membrane formation is demonstrated to be a late finding and the tadpole sign is an early phenomenon p.i. The data corroborated that the sediment but not the supernatant has the potential for being valuable for age-diagnostic aspects.

Key Points

QuestionReliable evidence-based data on the development of SDCs is sparse but required for expert opinions on pediatric AHT.

FindingsReference data on the evolution of the imaging appearance of SDCs and associated phenomena in confirmed cases of AHT are provided.

Clinical relevanceAs there is a great need for estimating the age of injury in criminal and civil proceedings, many clinical radiologists are confronted with the diagnostic and forensic aspects of AHT that are addressed in the present study.
A novel screening instrument for the assessment of autism in German language: validation of the German version of the RAADS-R, the RADS-R
Authors: Rausch Jördis , Fangmeier Thomas , Falter-Wagner Christine M. , Ackermann Helene , Espelöer Julia , Hölzel Lars P. , Riedel Andreas , Ritvo Ariella , Vogeley Kai , van Elst Ludger Tebartz
Published: October 2024

The Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) demonstrated excellent results in its original study, with a sensitivity of 97% and a specificity of 100% (Ritvo et al. in J Autism Dev Disord 41:1076–1089, 2011). As a result, it was included in the National Institute for Health and Care Excellence (NICE) guidelines (Recommendations | Autism spectrum disorder in adults: diagnosis and management | Guidance | NICE, 2022). The questionnaire includes 80 questions across four subcategories (language, social relatedness, circumscribed interests, sensory motor). So far, the subcategory sensory motor has not been addressed in most available instruments, despite being part of the diagnostic criteria specified in DSM-5 (Falkai et al., in Diagnostisches Und Statistisches Manual Psychischer Störungen DSM-5. Hogrefe, 2015) and ICD-11 (ICD-11 for Mortality and Morbidity Statistics, 2022). In our validation study, we tested a translated German version of the questionnaire in 299 individuals (110 persons with ASD according to ICD-10 F84.0, F84.5, 64 persons with an primary mental disorders (PMD), 125 persons with no disorders). To enhance the practical use of the instrument in clinical everyday practice, the questionnaire was completed by the participants without the presence of a clinician—unlike the original study. Psychiatric diagnoses were established following the highest standards, and psychometric properties were calculated using established protocols. The German version of the RADS-R yielded very good results, with a high sensitivity of 92.5% and a high specificity of 93.6%. The area under the curve (AUC = 0.976), indicates a high quality and discriminatory power of RADS-R. Furthermore, the ROC curve analysis showed that the optimal threshold to distinguish between the ASD and non-ASD groups in the German version of the RAADS-R is a score of 81. In comparison to the RADS-R, the co-administered instruments Social Responsiveness Scale (SRS), Autism Spectrum Quotient (AQ), and Empathy Quotient (EQ) each showed slightly better specificity but worse sensitivity in this sample.The study included individuals already diagnosed with ASD according to ICD-10 (F84.0, F84.5), with or without an primary mental disorders, preventing us from identifying the influence of comorbidities on the RADS-R results. In addition, a self-report questionnaire has generally only limited objectivity and may allow for false representation of the symptoms. The RADS-R compares well with other questionnaires and can provide valuable additional information. It could turn out to be a helpful diagnostic tool for patients in Germany. We propose naming the German version RADS-R (Ritvo Autism Diagnostic Scale – rRevised) to reflect the change in terminology.
The MorbidGenes panel: a monthly updated list of diagnostically relevant rare disease genes derived from diverse sources
Authors: Jauss Robin-Tobias , Popp Bernt , Bachmann Joachim , Abou Jamra Rami , Platzer Konrad
Published: October 2024

Purpose: With exome sequencing now standard, diagnostic labs are in need of a, in principle, to-the-day-accurate list of genes associated with rare diseases. Manual curation efforts are slow and often disease specific, while efforts relying on single sources are too inaccurate and may result in false-positive or false-negative genes. Methods: We established the MorbidGenes panel based on a list of publicly available databases: OMIM, PanelApp, SysNDD, ClinVar, HGMD and GenCC. A simple logic allows inclusion of genes that are supported by at least one of these sources, providing a list of all genes with diagnostic relevance. Results: The panel is freely available at https://morbidgenes.uni-leipzig.de and currently includes 5037 genes (as of October 2024) with minimally sufficient evidence on disease causality to classify them as diagnostically relevant. Conclusion: The MorbidGenes panel is an open and comprehensive overview of diagnostically relevant rare disease genes based on a diverse set of resources. The panel is updated monthly to keep up with the ever increasing number of rare disease genes.
Rapid remote volcanic ashfall impact assessment for the 2022 eruption of Hunga volcano, Tonga: a bespoke approach and lessons identified
Authors: Weir Alana M. , Williams James H. , Wilson Thomas M. , Hayes Josh L. , Stewart Carol , Leonard Graham S. , Magill Christina , Jenkins Susanna F. , Williams Shaun , Craig Heather M. , Kula Taaniela , Fraser Stuart , Pomonis Antonios , Gunasekera Rashmin , Daniell James E. , Coultas Emma
Published: October 2024

When disasters occur, rapid impact assessments are required to prioritise response actions, support in-country efforts and inform the mobilisation of aid. The 15 January 2022 eruption of Hunga volcano, Tonga, and the resulting atmospheric shockwave, ashfall, underwater mass disturbance and tsunami, caused substantial impacts across the Kingdom of Tonga. Volcanic impacts on the scale observed after the eruption are rare, necessitating a reliance on international advice and assistance. The situation was complicated by the loss of Tonga’s international submarine fibreoptic cable (causing a complete loss of communications for approximately 20 days) along with border closures due to the COVID-19 pandemic. A need emerged for a rapid remote volcanic impact assessment and provision of specialist advice to help inform the response of international partners. Here we present a novel methodology for conducting rapid remote volcanic ashfall impact assessments, conducted over a 10-day period following the eruption. We used three different hazard models for ashfall thickness across the main island of Tongatapu and available asset information and vulnerability functions for buildings, agriculture, electricity networks, water supply and roads, to provide initial estimates of losses due to ashfall from the 15 January eruption. For buildings, we estimated losses both as total losses and as percentages of the total replacement cost of buildings on Tongatapu. For agriculture, we made probabilistic estimates of production losses for three different crop classes. For ashfall clean-up, we estimated ranges of ashfall volumes requiring clean-up from road surfaces and roofs. For water supply, electricity networks and roads, our analysis was limited to assessing the exposure of important assets to ashfall, as we had insufficient information on system configurations to take the analysis further. Key constraints on our analysis were the limited nature of critical infrastructure asset inventories and the lack of volcanic vulnerability models for tropical regions including Pacific Island nations. Key steps towards iteratively improving rapid remote impact assessments will include developing vulnerability functions for tropical environments as well as ground-truthing estimated losses from remote approaches against in-person impact assessment campaigns.
Cholecystectomy with the Hugo™ robotic-assisted surgery system: the first general surgery clinical study in Korea
Authors: Kwon Wooil , Jang Jin-Young , Jeong Chang Wook , Anselme Sylvain , Pradella Fabio , Woods Jacklyn
Published: October 2024

Background

The Hugo™ Robotic-Assisted Surgery (RAS) System is an emergent device in the robotic surgery field. This study aims to describe the first general surgery-focused clinical study in Korea using the novel Hugo™ RAS System.

Methods

This study was a prospective, single-center, single-arm, confirmatory clinical study conducted at Seoul National University Hospital where 20 cholecystectomies were performed. To evaluate the safety and performance of the Hugo™ RAS System the incidence of conversion to laparoscopy or open surgery, major complication (Clavien-Dindo Grade ≥ III) rate, overall complication rate, readmission rate, and reoperation rate were evaluated. All parameters were assessed within 30 days post-procedure. Any device deficiencies encountered during our initial experience and device data such as setup, console, and operative times were also reported.

Results

We confirmed that our trial achieved the primary objective with a success rate of at least 95%. This was accomplished with no conversions to other types of surgery due to serious system malfunction and with only one major complication within 24 h post-procedure. The 20 consecutively enrolled patients had a median age and BMI of 58 years old and 23.9 kg/m2, respectively. The major complication rate was 10% (2/20 patients), the overall complication rate was 15% (3/20 patients), the readmission rate was 15% (3/20 patients), and the reoperation rate was 0% (0/20 patients). None of the complications were definitively device related. The median setup, console, and operative times were 16, 17, and 55 min, respectively. The device deficiency rate was 15% (3/20 patients), but all device deficiencies were minor, occurred before the first incision, and did not present a risk to the patient.

Conclusion

Based on our initial experience with the Hugo™ RAS System, cholecystectomy is feasible and safe. This trial is registered with ClinicalTrials.gov (NCT05715827).
Obinutuzumab as a viable therapeutic strategy in rituximab-refractory childhood frequently relapsing, steroid-dependent nephrotic syndrome that relapsed during B-cell depletion
Authors: Chan Eugene Yu-hin , Lin Kyle Ying-kit , Yap Desmond Yat-hin , Ma Alison Lap-tak
Published: October 2024

A subgroup of children with frequently-relapsing, steroid-dependent nephrotic syndrome relapse during B-cell depletion after rituximab. A 15-year-old boy with focal segmental glomerulosclerosis became rituximab-refractory after 5 courses of treatments, with a relapse-free period shortened to 1 month. Circulating total and memory B-cells were undetectable at the time of relapse. A single infusion of obinutuzumab sustained relapse-free remission up to the last follow-up at 18 months. There was persistent hypogammaglobulinemia but no infection was observed. Obinutuzumab may be a viable option for attaining long-term remission with reasonable side effect profiles in patients who relapse during B-cell depletion after rituximab.
Photobiomodulation therapy for mitigating severity of radiodermatitis in cancer patients undergoing radiotherapy: a scoping review
Authors: Rao Devika , Dsouza Cliva Neha , Prabhu Smitha S , Kumar Praveen , Prabhu Vijendra
Published: October 2024

Purpose

Radiodermatitis (RD) is an adverse effect of radiation therapy. RD can negatively impact quality of life and can also hinder treatment in cancer patients. Photobiomodulation therapy (PBMT) has the potential to treat RD at the cellular level, and it is more promising compared to other therapy alternatives. This review aims to examine the effectiveness of PBMT for the treatment and management of RD in cancer patients undergoing radiation therapy.

Methods

The methodology followed for the review was based on the framework proposed by Arksey and O’Malley, and the extensions by Levac et al. This involved a literature search in Scopus, PubMed, Embase, and Cochrane without any time limit, for original articles on the basis of the inclusion criteria, i.e., studies focusing on the effectiveness of PBMT on RD in cancer patients undergoing radiation therapy as an anticancer treatment. The review has been reported on the basis of the PRISMA-ScR checklist.

Results

A total of 14 studies were reviewed, of which only 2 (14.28%) studies reported no significant effect of PBMT on RD; the remaining studies reported positive outcomes (85.71%) with no adverse effects. Among studies with positive outcomes, PBMT has been shown to be beneficial in reducing the severity of RD. Furthermore, PBMT application has been studied as a preventive measure (35.71%), treatment and management (50%), and for both the prevention and cure of RD (14.29%).

Conclusion

Overall, PBMT can be considered a reliable and effective treatment modality for reducing the severity of RD. However detailed studies related to the long-term effects of PBMT, its effect on pain intensity and quality of life (QoL) will aid in better assessment of the technique. More clinical trials with a broader sample size could also aid in fine-tuning the efficacy of PBMT treatment modalities.
How do patients with head and neck cancer and low skeletal muscle mass experience cisplatin-based chemoradiotherapy? A qualitative study
Authors: Schaeffers Anouk W. M. A. , van Beers Maartje A. , Devriese Lot A. , Klomp F. W. José , Westerink - van den Brink Chantal F. M. , Smid Ernst J. , de Bree Remco , Speksnijder Caroline M.
Published: October 2024

Background

Patients with head and neck squamous cell carcinoma (HNSCC) face several physical, emotional, and psychological challenges throughout treatment. Cisplatin-based chemoradiotherapy (CRT) is an effective but toxic treatment, with an increased risk for toxicities in patients with low skeletal muscle mass (SMM). Consequently, these patients are anticipated to experience greater treatment-related difficulties. We aimed to explore the experiences of patients with HNSCC and low SMM regarding cisplatin-based CRT.

Methods

A descriptive qualitative study was conducted, interviewing seven patients 3 months after CRT using a topic guide. Thematic analysis of semi-structured interviews was conducted, to create a multi-dimensional understanding of patients’ experiences during and after cisplatin-based CRT.

Results

Prior to CRT themes included pre-treatment information, expectations towards treatment and trial, psychosocial circumstances, and supporting network. During CRT themes included toxicities, psychosocial impact, and supporting network. After CRT themes included reflection on period during CRT, psychosocial circumstances, informal support from networks and healthcare workers, and ongoing toxicities.

Conclusion

Most patients experience cisplatin-based CRT as a life-changing and distressing life event but cope through various strategies and supporting networks. Tailored counseling, ideally with on-demand consultations, is recommended. No differences were noted in patients’ perceptions of their cisplatin regimen.
The “greywacke problem” explored in the Neoproterozoic of Saxo-Thuringia: new insights into sediment composition and metamorphic overprint
Authors: Kühnemann Victoria , Meinhold Guido , Schulz Bernhard , Gilbricht Sabine , Weber Sebastian , Wemmer Klaus
Published: October 2024

Greywackes make up a substantial part of the Cadomian basement of Saxo-Thuringia. Here, their classification as greywackes and the timing of metamorphic overprint are re-evaluated using a multi-method approach. Immature monotonous greywacke sequences from the Lausitz (Lausitz Block) and Leipzig groups (North Saxon Anticline), as well as from the eastern Thuringian Basin and parts of the Weesenstein Group (Elbe Zone) probably belong to a coherent unit, based on microscopic investigations supported by SEM Automated Mineralogy analyses and point counting data. However, due to the low matrix content (< 15%), the sedimentary rocks are more likely classified as lithic sandstones. The heterogeneous composition and in particular the highly mature character of the Clanzschwitz Group (North Saxon Anticline) and parts of the Weesenstein Group (Seidewitz Formation) suggest a younger, Late Cambrian to Early Ordovician sedimentation age. Typically, the metamorphic overprint of the “greywacke units” is very weak. Previous assumptions of Cadomian contact metamorphism triggered by Early Cambrian intrusions (ca. 540 Ma) could not be confirmed due to the local differences in the determined metamorphic ages. Late Cambrian to Early Ordovician (521–461 Ma) Th–U–Pb monazite ages are likely related to the tectonic transition from the collisional regime of the Cadomian orogeny to extensional processes in the course of the opening of the Rheic Ocean. Sporadic Late Ordovician (458–445 Ma) Th–U–Pb monazite and K–Ar fine-fraction ages were also obtained but the specific thermal trigger is still subject of debate. The Permo-Carboniferous metamorphic ages (314–286 Ma) indicate high-temperature metamorphism related to the post-Variscan extensional processes of Central Europe during this period. The youngest dated monazites are Jurassic in age and may have grown in association with the hydrothermal activity known from Central Europe at that time.

Graphical abstract
Methodological considerations in calculating the minimal clinically important change score for the core outcome measures index (COMI): insights from a large single-centre spine surgery registry
Authors: Cina Andrea , Vitale Jacopo , Haschtmann Daniel , Loibl Markus , Fekete Tamas F. , Kleinstück Frank , Galbusera Fabio , Jutzeler Catherine R. , Mannion Anne F.
Published: October 2024

Introduction

The Minimal Clinically Important Change (MCIC) is used in conjunction with Patient-Reported Outcome Measures (PROMs) to determine the clinical relevance of changes in health status. MCIC measures a change within the same person or group over time. This study aims to evaluate the variability in computing MCIC for the Core Outcome Measure Index (COMI) using different methods.

Methods

Data from a spine centre in Switzerland were used to evaluate variations in MCIC for the COMI score. Distribution-based and anchor-based methods (predictive and nonpredictive) were applied. Bayesian bootstrap estimated confidence intervals.

Results

From 27,003 cases, 9821 met the inclusion criteria. Distribution-based methods yielded MCIC values from 0.4 to 1.4. Anchor-based methods showed more variability, with MCIC values from 1.5 to 4.9. Predictive anchor-based methods also provided variable MCIC values for improvement (0.3–2.4), with high sensitivity and specificity.

Discussion

MCIC calculation methods produce varying values, emphasizing careful method selection. Distribution-based methods likely measure minimal detectable change, while non-predictive anchor-based methods can yield high MCIC values due to group averaging. Predictive anchor-based methods offer more stable and clinically relevant MCIC values for improvement but are affected by prevalence and reliability corrections.
Potential for 50% Mechanical Strength Decline in Sandstone Reservoirs Due to Salt Precipitation and CO2–Brine Interactions During Carbon Sequestration
Authors: Nooraiepour Mohammad , Polański Krzysztof , Masoudi Mohammad , Kuczyński Szymon , Derluyn Hannelore , Nogueira Liebert Parreiras , Bohloli Bahman , Nagy Stanislaw , Hellevang Helge
Published: October 2024

Predictive modeling of CO2 storage sites requires a detailed understanding of physico-chemical processes and scale-up challenges. Dramatic injectivity decline may occur due to salt precipitation pore clogging in high-salinity aquifers during subsurface CO2 injection. This study aims to elucidate the impact of CO2-induced salt crystallization in the porous medium on the geomechanical properties of reservoir sandstones. As the impact of salt precipitation cannot be isolated from the precursor interactions with CO2 and acidified brine, we present a comprehensive review and discuss CO2 chemo-mechanical interactions with sandstones. Laboratory geochemical CO2–brine–rock interactions at elevated pressures and temperatures were conducted on two sandstone sets with contrasting petrophysical qualities. Interaction paths comprised treatment with (a) CO2-acidified brine and (b) supercritical injection until brine dry-out, salt crystallization, and growth. Afterward, the core samples were tested in a triaxial apparatus at varying stresses and temperatures. The elastic moduli of intact, CO2-acidified brine treated, and salt-affected sandstones were juxtaposed to elucidate the geochemical–geomechanical-coupled impacts and identify the extent of crystallization damages. The salt-affected sandstones showed a maximum of 50% reduction in Young’s and shear moduli and twice an increase in Poisson’s ratio compared to intact condition. The deterioration was notably higher for the tighter reservoir sandstones, with higher initial stiffness and lower porosity–permeability. We propose two pore- and grain-scale mechanisms to explain how salt crystallization contributes to stress localization and mechanical damage. The results highlight the potential integrity risk imposed by salt crystallization in (hyper)saline aquifers besides injectivity, signaling mechanical failure exacerbated by pressure buildup.
Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial
Authors: Nawar Nawar Naguib , Elashiry Mohamed Mohamed , El Banna Ahmed , Saber Shehabeldin Mohamed , Schäfer Edgar
Published: October 2024

Objectives

This 2-part randomized parallel triple-blind clinical trial adopts a unique model assessing clinically-set hydraulic calcium silicate-based sealers (HCSBS) after different root canal dryness protocols and obturation techniques.

Methods

For the first phase of the study, 24 teeth scheduled for orthodontic extractions were allocated into four groups according to the canal dryness protocol and the obturation technique. G1 (CLC-AHP): cold lateral compaction (CLC) with AH Plus sealer, G2 (CLC-ES-SD): CLC with Endosequence (ES) after standard canal(s) dryness (SD); G3 (SC-ES-SD): matching single-cone (SC) with ES after SD; G4 (SC-ES-PD): as G3 but after partial canal(s) dryness (PD). Teeth were extracted after one month of clinical service and examined for intracanal voids by micro-CT (2D & 3D). For the 2nd phase, another 24 teeth were allocated into four groups according to the root canal dryness protocol and the HCSBS used (ES or CeraSeal (CeS)). Teeth were extracted after one month and sectioned vertically for energy dispersive X-ray (EDX)/scanning electron microscope (SEM) examination. One-way ANOVA with Games-Howell post-hoc test and Chi-square test with multiple z-tests were used for statistical analysis.

Results

SC-PD showed the highest percentage of voids (p < 0.05). MicroCT scans as well as EDX/SEM examination showed that PD resulted in significantly larger interfacial gaps (p < 0.001) with more hydration products at the sealer/dentin interface than SD.

Conclusions

Both tested dryness protocols allowed the hydration of HCSBS and the formation of hydration products, thus standard dryness is recommended to reduce the incidence of intracanal voids.

Clinical relevance

When using the single-cone obturation technique, intentional root canal moisture negatively affects the performance of HCSBS.

Protocol Registration

http://www.clinicaltrials.gov, ID: NCT05808062.
Sugar alcohol degradation in Archaea: uptake and degradation of mannitol and sorbitol in Haloarcula hispanica
Authors: Ortjohann Marius , Schönheit Peter
Published: October 2024

The halophilic archaeon Haloarcula hispanica utilizes the sugar alcohols mannitol and sorbitol as carbon and energy sources. Genes, enzymes, and transcriptional regulators involved in uptake and degradation of these sugar alcohols were identified by growth experiments with deletion mutants and enzyme characterization. It is shown that both mannitol and sorbitol are taken up via a single ABC transporter of the CUT1 transporter family. Then, mannitol and sorbitol are oxidized to fructose by two distinct dehydrogenases. Fructose is further phosphorylated to fructose-1-phosphate by a haloarchaeal ketohexokinase, providing the first evidence for a physiological function of ketohexokinase in prokaryotes. Finally, fructose-1-phosphate is phosphorylated via fructose-1-phosphate kinase to fructose-1,6-bisphosphate, which is cleaved to triosephosphates by a Class I fructose-1,6-bisphosphate aldolase. Two distinct transcriptional regulators, acting as activators, have been identified: an IclR-like regulator involved in activating genes for sugar alcohol uptake and oxidation to fructose, and a GfcR-like regulator that likely activates genes involved in the degradation of fructose to pyruvate. This is the first comprehensive analysis of a sugar alcohol degradation pathway in Archaea.
A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria
Authors: Corbetta Davide , Grau-Roma Llorenç , Rees Catherine , Swift Benjamin Michael Connor , O’Cathail Colman , Barron Elsa Sandoval , Verin Ranieri , Morey-Matamalas Antonia , Sorley Marion , Bennett Malcolm
Published: October 2024

European badgers (Meles meles) play an important role in the epidemiology of bovine tuberculosis (caused by Mycobacterium bovis) in England, but little is known about the prevalence of atypical mycobacteriosis. Badgers are also known to be infected by other infectious agents, and the relationship between mycobacteriosis and concomitant infections needs further investigation. Overall, 88 badger carcasses from the Midlands of England collected between July 2016-August 2017 were selected for histopathological examination based on the degree of autolysis (mild), mycobacterial culture results and a balanced sex ratio. Mycobacteria were cultured from 44 badgers, of which 31 were mycobacteria belonging to the M. tuberculosis complex (MTBC) (based on IS6110 PCR and Hsp64 and/or rRNA PCR and sequencing) and 13 were non-tuberculous atypical mycobacteria (NTM). Mycobacteria were not cultured from the remaining 44 animals. Histologically, the most common findings were silica-laden macrophages (85%), granulomas (53%), sarcocystosis (47%), nephritis (31%), portal/periportal hepatitis (26%), ulcerative dermatitis (18%). Culturable mycobacteriosis was associated with higher prevalence of granulomas (p < 0.001) and lower prevalence of hepatitis (p = 0.003). NTM (M. nonchromogenicum, M. avium complex, M. hassiacum, M. malmoense, M. vaccae.) infections were associated with granulomatous pneumonia, and M. malmoense was associated with pyogranulomatous and ulcerative dermatitis. In conclusion, this study describes, for the first time, histological lesions associated with NTM in badgers, the histomorphology of which was similar to those caused by MTBC. In addition, the negative relationship between mycobacteriosis and periportal hepatitis may indicate a complex relationship between mycobacteriosis and other diseases, as previously observed with tuberculosis.
Seed-Assisted Hydrothermal Synthesis of Monodispersed Au@C Core–Shell Nanostructures for Enhancing Thermal Diffusivity of Water-Based Nanofluids
Authors: Cadena-Torres E. , Ruiz-Peralta Ma. de L. , Sanchez-Ramirez J. F. , Vilchis-Nestor A. R. , Jiménez-Pérez J. L. , Gutiérrez-Fuentes R. , Vela-Vázquez R. , Escobedo-Morales A.
Published: October 2024

Au@C core–shell nanostructures (Au@C-NS) were synthesized through a low-temperature seed-assisted hydrothermal approach using glucose as carbon source. The material characterization and chemical analysis confirm that the synthesis method allows to obtain uniform core–shell nanostructures constituted by a crystalline metal core and an amorphous carbon shell. Depending on the synthesis conditions, their average size ranges from 146 nm to 342 nm with relative standard deviation as low as 7 %. It is proposed that the characteristic monodispersity results due to a high nucleation rate of the carbon phase at the liquid–solid interface. The obtained monodisperse Au@C-NS were used to prepare water-based nanofluids with superior heat transport properties. The thermal lens analysis shows that the thermal diffusivity of Au@C nanofluids is 9.5 % and 31.3 % higher than their Au nanofluids counterparts and pure water, respectively, at particle concentration of 285 × 1011 ml−1. Phonon-related interactions at the metal cores and carbon shells interfaces are proposed as the heat transport mechanism behind the thermal diffusivity enhancement of the Au@C water-based nanofluids.
Fostering technical skills and creativity in the digital fabrication spaces: an open-ended prototyping approach
Authors: Soomro Sohail Ahmed , Nanjappan Vijayakumar , Casakin Hernan , Georgiev Georgi V.
Published: October 2024

This paper explores the impact of a digital fabrication course on the development of digital fabrication skills and creativity. The course focused on open-ended prototyping and aimed to investigate its effects on students’ motivation, enjoyment, and confidence. Students’ creativity levels were measured using a creativity test at the beginning and end of a seven-week course. Additionally, the students shared their subjective feedback on their skills and experiences in designing and fabricating prototypes using digital fabrication tools. The results showed that prototyping activities significantly improved students’ overall creativity and perceived proficiency in 2D and 3D modeling, prototyping, embedded programming, and operating fabrication machines. Students’ confidence increased across most skills, although some of their motivation and enjoyment for certain skills decreased by the end of the course. It was also revealed that collaborative learning was perceived as enjoyable and not always suitable for developing certain personal skills, such as 2D modelling and programming. Future research could investigate pedagogical approaches tailored to individual needs and collaborative configurations for optimal skill development.