Hemodynamic Changes Secondary to Aortic Occlusion and Shock Are Not Mediated by Oxygen Free Radicals
Authors: Vo Nghia M. , Dunbar Jacob , Stanton Paul E. 
Published: November 2007

Since the ischemia/reperfusion syndrome may be associated with generation of oxygen free radicals (OFR), this study was designed to evaluate the effects of OFR inhibitors (allopurinol, superoxide dismutase) on the hemodynamic pa rameters associated with aortic clamping and shock.

Normotensive animals showed minimal hemodynamic changes following a two-hour clamping and declamping of the aorta. Hypotensive occlusion was, however, associated with significant myocardial depression one hour after clamping in control and treated animals. No other major hemodynamic changes were noted between various groups at various phases of the experiment.

The authors conclude that (1) myocardial depression occurs mainly with hypotensive occlusion and (2) OFR are not involved in these hemodynamic changes. The latter may be related to myocardial dysfunction secondary to hy povolemia.

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