bluuebunny/crossref_metadata_2025 huggingface dataset:
After the Kazym rebellion: on one report on the collection of operational information from the Sosva Mansi in 1934
Authors: Bogordayeva A.A. , Liskevich N.A.
Published: June 2023

The purpose of the article is to analyze and publish a report on the collection of operational information by the Khanty-Mansiysk District Committee of the All-Union Communist Party (Bolsheviks) after the Kazym uprising of 1933–1934. The report is dated March 7, 1934, and it contains information about life, rights and customs of the indigenous inhabitants of the Sosva and Lyapin river basins located in the Berezovsky district of the Khanty-Mansi Autonomous Okrug — Yugra (North-Western Siberia). In the history of the study of the Kazym rebellion, several main research lines are noted, including the identification and analysis of the factors of the uprising, their impact on life of the indigenous population, and also the analysis of the actions of the authorities to suppress the rebellion and to prevent similar protests. The events related to the Kazym rebellion and its consequences are preserved in historical and social memory. However, the documents still exist reflecting the actions of the authorities to prevent such events, which have not yet been introduced into scientific circulation. The prevention of protest movements was associated, first of all, with the identification of the “counter-revolutionary” sentiments locally, as well as of the religious and social status of local residents, and with the fight against shamanism and “kulaks”. A similar task was performed by an unknown author of the report. The report represents a logical narrative, with an emphasis on information related to the manifestation of religiosity by local residents and their attitudes towards the Kazym uprising; it contains the author's critical statements on his own observations and ends with recommendations for verifying the revealed facts. The author provides ethnographic description of the lifestyle, houses, dress, everyday features, home sanctuaries and cult attributes, bear celebration, maternity rites. In a number of cases, the document contains errors — in the name of the people living in the area, in the names of settlements. At the same time, noteworthy is the information on bear fangs, men's and women's hairstyles, the custom of “borrowing” from the sacrifices of the spirit, inter-ethnic relations, etc. Of particular value is the data on the rite of transition of a mother with a child back to the residential building after the childbirth, recorded in Verkhnenildino (Nildino), on the abandonment of a dwelling after the death of two children within it from illness (measles) in the village of Shomy (Shom). The information presented here largely complements the available materials on the social processes in the 1930s and represents a valuable source on the culture and life of the population of northern Sosva at the beginning of the 20th century.
The buzzer: not just a toy
Authors: Shagapova G.R.
Published: June 2023

The article analyzes the buzzer toy for boys. It is very easy to make from a button with a rope passing through the two holes. In past times, it was made of wood, bone plate, leather. When the rope with the plate is twisted and sharply released, the toys make a specific sound. The name of the toy in many languages reflects its buzzing. The aim of this work is to study the geography of the buzzer game in the Old and New Worlds and to reconstruct the ritual that underlies the game. The main research methods are mapping and comparative-historical method. The source base is represented by published materials on the games of the peoples of the world, as well as the author's field materials from the Southern Urals. The following conclusions have been drawn: the toy is most commonly young male, all-season, and is associated with sound. Sound in archaic culture played an important role; it limits and structures space, establishes contacts between the worlds and protects a person from evil spirits. In most cases, the buzzer has lost its sacred meaning, but among the peoples of the North, Sibe-ria, and the Far East, the elements of the ritual are still tangible which makes it possible to reconstruct the male ritual. The ritual was aimed at weather change, and at influencing the existing state of affairs. The geography of the buzzer distribution in North America and Eurasia has been studied. It can be assumed that it came to the New World from Eurasia, shortly before the disappearance of Beringia. The agreement of details and specifics of its use suggest its connection with the ritual. Subsequently, the ritual spread together with tribes and cultures, and to date, all that has remained from the millennial ritual is just a noise toy in children’s hands.
On the issue of construction of social memory: anthropology of the “Perm-36” museum
Authors: Riazanova S.V.
Published: June 2023

The study does not imply either documentation of the repressions, or working in the field of oral history. The article provides a vision of how the key figures in the history of the museum form its history and image. The source base includes a series of expert interviews with the founders and administrators of the museum at various stages of its existence, and a number of concepts for the arrangement of Perm-36 during various years, as well as Internet and media publications, allowing to verify the obtained data. The text attempts to reconstruct the his-tory of the formation and functioning of the Perm-36 museum, highlighting the periods of its activity associated with a change in leadership and the appointment of a number of new employees in its management and research structures. In the process of the analysis, the author compares various perspectives on what is the purpose of the museum located at the site of the camp, and what is the place of the museum in the socio-political reality. The analy-sis is based on the identification of groups of statements related to various aspects of creation and functioning of the Perm-36 memorial complex. The museum is considered as a place of application of multidirectional efforts of various actors, which provokes significant changes in approaches to its arrangement and to its functions in the public space. The concept of “demiurge” is introduced to designate a social agent who constructs the space of historical and social memory based on its own ideas and vision. Public figures, researchers and museum employees, who play a signifi-cant role in determining the structure of museum collections, ways of their presentation and types of social activities, are seen as the key factor that shapes the image of the museum in the region, nationally, and internationally. The material base in this situation appears secondary to the methods of its interpretation, principles of selecting items, and the use of supplementary means for their exhibiting. Research interests, social agenda and personal ambitions of the main actors become determinant for the formation of the museum chronotope.
The hoard of the Early Iron Age at the settlement of Dianovo-II (Belozersk district of the Kurgan region)
Authors: Riabinina E.A. , Maslyuzhenko D.N. , Spiridonov I.А. , Usachev E.V.
Published: June 2023

In 2016, in the area of Dianovo village of the Belozersk district of the Kurgan region (West Siberia), a hoard of the Early Iron Age artifacts was found. While examining the area for the identification of structures of the Civil War period, a round-bottomed vessel was accidentally discovered. Inside the container, there was a massive rectangular bronze plate, glass beads, and fragments of jewelry, including bronze strings, bronze plaques in the shape of fish and four-petal plaques strung on leather cords, all wrapped in organic material (felt?). In total, the Dianovo treasure contains 370 ob-jects made of bronze and glass, assembled within a single set, classified as women’s. At present, this is one of very few elements of the women’s costume of the Early Iron Age that have been best preserved in the Southern Trans-Urals. These finds were transferred to the archaeological laboratory of the Kurgan State University, and later the archaeologi-cal survey was carried out at the discovery location by I.A. Spiridonov. The purpose of this research is a typological description of the contents of the hoard, its chronological analysis, and a possible reconstruction of the bronze orna-ment. The main research materials are the container in which the treasure was found — a ceramic round-bottomed vessel, a set of bronze objects that piece together a female (breast?) adornment, a set of glass beads of three types (rounded blue, black (square and rounded) with festoon-like white and yellow pattern), and a massive bronze plate with traces of manufacturing, which probably had the purpose of an ingot. Based on the analysis of the materials, it has been established that the hoard was most likely left by the population of the Gorokhovskaya Culture. This conclusion was made on the basis of the shape and features of the ceramic vessel. This is also supported by the location of the treasure and the general dating of individual items: glass beads of the Black Sea origin have numerous similarities in the sites and are quite clearly dated by these analogues to the 4th–3rd c. BC. The dating of other items of the hoard — elements of the bronze ornament and a bronze ingot-plate is complicated due to the lack of clearly dated analogues or chronological duration of their use. Judging by the composition and carefulness of packing of the items, this hoard ap-parently was of a situational (possibly in the event of an attack) and returnable character.
A Scrutiny of Landmark Experiments Disproves Photonic Quantum Nonlocality
Authors: Vatarescu Andre
Published: June 2023

A physical scrutiny of experimental results published in Physical Review Letters (December 2015, M. Giustina, et al., Phys. Rev. Lett. 115, 250401, and L. K. Shalm et al., Phys. Rev. Lett. 115, 250402) is undertaken. These articles reported that measured outcomes were fitted with quantum states possessing a dominant component of non-entangled photons, thereby contradicting their own claim of quantum nonlocality. With probabilities of photon detections lower than 0.1 %, the alleged quantum nonlocality cannot be classified as a resource for developing quantum computing devices, despite recent publicity. Experimental evidence of a feasible process for quantum-strong correlations has been identified (M. Iannuzzi, et al., Phys. Lett. A, 384 (9), 126200, 2020) in terms of correlations between independent and multi-photon states evaluated as Stokes vectors on the Poincaré sphere. As single-photon sources are not needed, the design and implementation of quantum computing operations will be significantly streamlined.
Specific methyl-CpG configurations define cell identity through gene expression regulation.
Authors: Improda Teresa , Morgera Valentina , Vitale Maria , Chiariotti Lorenzo , Passaro Fabiana , Feola Antonia , Porcellini Antonio , Cuomo Mariella , Pezone Antonio
Published: June 2023

Cell identity is determined by chromatin structure and the profiles of gene expression, which are dependent on chromatin accessibility and DNA methylation of regions critical for gene expression, such as enhancers and promoters. These epigenetic modifications are required for mammalian development and are essential for the establishment and the maintenance of the cellular identity. DNA methylation was once thought to be a permanent repressive epigenetic mark, but systematic analysis in various genomic contexts reveals a more dynamic regulation than previously thought. In fact, both active DNA methylation and demethylation occur during cell fate commitment and terminal differentiation. To link methylation signatures of specific genes to their expression profiles, we have determined the methyl-CpG configurations of the promoters of five genes switched on and off during murine postnatal brain differentiation by bisulfite-targeted sequencing. We report here the structure of significant, dynamic and stable methyl-CpG profiles associated with silencing or activation of expression of genes during neural stem cell and brain postnatal differentiation. Strikingly, these methylation cores mark different mouse brain areas and cell types derived from the same areas during differentiation.
SL-Swin: A Transformer-Based Deep Learning Approach for Macro- and Micro-Expression Spotting on Small-Size Expression Datasets
Authors: He Erheng , Chen Qianru , Zhong Qinghua
Published: June 2023

In recent years, the analysis of macro- and micro-expression has drawn the attention of researchers since they provide visual cues of an individual’s emotions for a broad range of potential applications such as lie detection and criminal detection. In this paper, we address the challenge of spotting facial macro- and micro-expression from videos and present compelling results by using a deep learning approach to analyze the optical flow features. Different from other deep learning approaches that are mainly based on Convolutional Neural Networks (CNNs), we propose a Transformer-based deep learning approach that predicts a score indicating the probability of a frame being within an expression interval. Unlike other Transformer-based models that achieve high performance by being pre-trained on large datasets, our deep learning model, called SL-Swin, which applies Shifted Patch Tokenization and Locality Self-Attention to the backbone network Swin Transformer, effectively spots macro- and micro-expressions by being trained from scratch on small-size expression datasets. Our evaluation outcomes surpass the MEGC 2022 spotting baseline result, obtaining an overall F1-score of 0.1366. Additionally, our approach also performs well in the MEGC 2021 spotting task with an overall F1-score of 0.1824 and 0.1357 on CAS(ME)2 and SAMM Long Videos, respectively. The code is publicly available on GitHub (https://github.com/eddiehe99/pytorch-expression-spotting).
Current Technologies for Managing Type 1 Diabetes Mellitus and Their Impact on Quality of Life - A State-of-Art Review
Authors: Elian Viviana , Popovici Violeta , Ozon Emma-Adriana , Musuc Adina Magdalena , Fița Ancuța Cătălina , Rusu Emilia , Radulian Gabriela , Lupuliasa Dumitru
Published: June 2023

Type 1 Diabetes mellitus (T1DM) occurs when insulin is not produced in the Pancreas due to the autoimmune destruction of the beta cells. The patients may be diagnosed after 80-90% of the beta cells are destroyed. Insulin remains the essential medicine in T1DM management, under continuous monitoring of glucose levels. T1DM management consists of a complex and precise set of self-care measures for the entire life; during this continuous process, the patients could become overwhelmed, angry, anxious, frustrated, and/or discouraged. Therefore, to be widely used and provide general benefits, new technologies for DM management must provide clinical advantages without compromising safety. The compliance of T1DM patients is also essential, thus improving their quality of life (QoL). Moreover, the accessibility of the new system for patients through healthcare coverage is critical; they must be able to buy the new devices and accessories and pay for their maintenance. In this context, our work aims to describe the most recent technologies regarding continuous glucose monitors (CGMs) and continuous subcutaneous insulin infusion (CSII) systems, correlated with psychosocial impact and capacity to improve T1DM patients' life quality.
Influence Sustainable Development on Management Risk in the NPL Portfolio in the Western Balkan Countries
Authors: Vesic Tamara , Cogoljevic Vladan , Gavrilović Milan D. , Barjaktarović Miljana , Milićević Raica , Roganović Miloš , Cvetković Milica , Vojvodić Miljković Nevenka , Radić Nikola
Published: June 2023

Concept sustainable of banking is based on principle realization growth and profit for the bank and shareholders, but only with achievement social goals, as and care for conservation life environment. Providing new ones banking service and creation new ( green ) banking jobs, except for _ profitable, they achieve and spreads social and ecological goals, chances are with creation competitive advantages, both in countries Western Balkans observed in the work, so and in all countries of the world In this one work we will focus on analysis macroeconomic parameters in countries Western Balkans works tests influence selected indicators on performance banking system, with special in retrospect on social and component protection life environment. The results indicate that rate unemployment the most significant indicator potentially risky events for bankers, as and banks they are not recognized in national conservation strategies _ life environment which are in WB countries currently on strength. Accordingly, the former is necessary to carry out education foreign affairs, and in parallel to promote green loans like they live and in the long term more favorable of traditional loans, with update the existing one regulatory frame in the domain protection life environment.
Functionalized Collagen/Poly(Ethylene Glycol) Diacrylate Interpenetrating Network Hydrogel Enhances Beta-Pancreatic Cell Sustenance
Authors: Moreno-Castellanos Natalia , Cuartas-Gomez Elías , Vargas-Ceballos Oscar
Published: June 2023

Three-dimensional matrices are a new strategy used to tackle type I diabetes; a chronic metabolic disease characterized by the destruction of beta pancreatic cells. Type I collagen is an abundant extracellular matrix (ECM), component that has been used to support cell growth. However, pure collagen possesses some difficulties including low stiffness and strength, and high susceptibility to cell-mediated contraction. Therefore, we developed a collagen hydrogel with a poly(ethylene glycol) diacrylate (PEGDA) interpenetrating network (IPN), functionalized with vascular endothelial growth factor (VEGF) to mimic the pancreatic environment for the sustenance of beta-pancreatic cells. We analyzed the physicochemical characteristic of the hydrogels and found that they were successfully synthesized. The mechanical behavior of the hydrogels improved with the addition of VEGF, and the swelling degree and the degradation were stable over time. In addition, it was found that 5 ng/mL VEGF-functionalized collagen/PEGDA IPN hydrogels sustained and enhanced viability, proliferation, respiratory capacity and functionality of beta pancreatic cells. Hence, this is a potential candidate for future preclinical evaluation, which may be favorable for diabetes treatment.
Uncovering Bias in Objective Mapping and Subjective Perception of Urban Building Functionality: A Machine Learning Approach to Urban Spatial Perception
Authors: Zhang Jiaxin , Yu Zhilin , Li Yunqin , Wang Xueqiang
Published: June 2023

Urban spatial perception critically influences human behavior and emotional reactions, emphasizing the necessity of aligning urban spaces with human needs for enhanced urban living. However, functionality-based categorization of urban architecture is prone to biases, stemming from disparities between objective mapping and subjective perception. These biases can result in urban planning and designs that fail to cater adequately to the needs and preferences of city residents, negatively impacting their quality of life and the city's overall functionality. In this study, we apply machine learning to elucidate these biases within urban spatial perception research, utilizing a three-step methodology: objective mapping, subjective perception analysis, and perception deviation assessment. Our findings reveal that machine learning can expose hidden patterns within this research field, bearing substantial implications for urban planning and design. Of particular note, the study revealed significant discrepancies in the distribution centroids between commercial buildings and residential or public buildings. This result illuminates the spatial organization characteristics of urban architectural functions, serving as a valuable reference for urban planning and development. Moreover, it uncovers the advantages and disadvantages of different data sources and techniques in interpreting urban spatial perception, paving the way for a more comprehensive understanding of the subject. These findings underscore the importance of integrating both objective mapping and subjective perspectives in urban architectural functionality classification.
Does Human Papillomavirus Play a Causative Role in Prostate Cancer:
A Systematic Review Using Bradford Hill’s Criteria
Authors: Opeyemi Bello Ridwan Opeyemi , Willis-Powell Lily , James Olivia , Sharma Avyay , Marsh Elizabeth , Ellis Libby , Gaston Kevin , Siddiqui Yusra Hasan
Published: June 2023

Prostate cancer contributes to cancer-related deaths globally, and the etiology of this disease is not yet fully understood. While Human Papillomavirus (HPV) has been associated with several types of cancer, including cervical, anal, and oropharyngeal cancer, studies investigating the relationship between HPV and prostate cancer have shown mixed results. This systematic review aimed to evaluate the causative association between HPV and prostate cancer using Bradford Hill's criteria. A comprehensive search of PubMed was conducted, and 60 out of 482 studies were included in the review. The included studies were evaluated based on nine Bradford Hill criteria, and information on the identification and transmission of the virus and potential oncogenic mechanisms was also extracted. The strength of association criterion was not met, and other criteria, such as consistency and coherence, were not fulfilled. However, biological plausibility was supported, and potential oncogenic mechanisms were identified. While some studies have reported the presence of HPV in prostate cancer tissues, the overall quality of evidence remains low, and the association between HPV and prostate cancer is weak. Nevertheless, the prostate is a potential reservoir for the transmission of HPV, and the HPV E6 and E7 oncoproteins and inflammation are likely to be involved in any oncogenic mechanisms. Further studies with a higher level of evidence are needed to establish a definitive link between HPV and prostate cancer.
Lightweight Co3O4/CC Composites with High Microwave Absorption at Low Frequency
Authors: An Bing , Wu Mei , Yang Xinhuang , Man Zengming , Liang Xiaohui , Feng Chunyang
Published: June 2023

With the rapid development of electronic and communication technology in military radar, the demand for microwave absorbing materials in low-frequency with thin layer is growing increasingly. In this study, flexible Co3O4/CC (carbon cloth) composites derives from Co-MOFs (metal-organic frameworks)/CC are prepared by hydrothermal and thermal treatment processes. The flexible precursors of Co-MOFs/CC are calcined with different calcination temperatures, which the material structure, dielectric properties and microwave absorption performance are changed. With the increase of calcination temperature, the minimum reflection loss of the corresponding Co3O4/CC composites gradually moves to the lower frequency with thinner thickness. In addition, the Co3O4/CC composites with 25 wt% filler loading ratio exhibit the minimum reflection loss (RL) of -46.59 dB at 6.24 GHz with 4.2 mm thickness. When the thickness is 3.70 mm, the effective absorption bandwidth is 3.04 GHz from 5.84 to 8.88 GHz. This study not only proves that the composite Co3O4/CC is a kind of outstanding microwave absorbing material with better flexibility, but also provides a useful inspiration for the low frequency and broadband microwave absorbing material.
Dirichlet Process Log Skew-normal Mixture with Missing at Random Covariate in Insurance Claim Analysis
Authors: Kim Minkun , Lindberg David , Crane Martin , Bezbradica Marija
Published: June 2023

In actuarial practice, the modeling of total losses tied to a certain policy is a non-trivial task. Traditional parametric models to predict total losses have limitations due to complex distributional features such as extreme skewness, zero inflation, multi-modality, etc., and the lack of explicit solutions for log-normal convolution. In the recent literature, the application of the Dirichlet process mixture for insurance loss has been proposed to eliminate the risk of model misspecification biases; however, the effect of covariates as well as missing covariates in the modeling framework is rarely studied. In this article, we propose novel connections among covariate-dependent Dirichlet process mixture, log-normal convolution, and missing covariate imputation. Assuming an individual loss is log-normally distributed, we develop a log skew-normal Dirichlet process to approximate the log-normal sum. As a generative approach, our framework models the joint of outcome and covariates, which allows to impute missing covariates under the assumption of missingness at random. The performance is assessed by applying our model to several insurance datasets, and the empirical results demonstrate the benefit of our model compared to the existing actuarial models such as the Tweedie-based generalized linear model, generalized additive model, or multivariate adaptive regression spline.
Generalized Virtual Displacement Principles of Deformed Objects with Methods of Analytical Mechanics
Authors: Fu Jingli , Xiang Chun , Yin Zuoyuan
Published: June 2023

Analytical mechanics is the most basic discipline. The basic principles of analytical mechanics should also be applicable to general deformed objects. However, the virtual displacement principle proposed by analytical mechanics is only applicable to particle systems and rigid body systems, but not to general deformed objects. In this paper, the generalized virtual displacement principle of general deformed objects (such as, elastic objects, plastic objects, elasto-platic objects and flexible objects etc ) is derived by the method of analytical mechanics, which is also applicable to particle systems and rigid body systems. First of all, according to the method of analytical mechanics, the external force, internal force, constraint reaction force and elastic recovery force of the deformed object system under the equilibrium state are analyzed, and the concepts of virtual displacement, ideal constraint and virtual work are introduced, and the generalized virtual displacement principle (also called generalized virtual work principle) of deformed objects is proposed; secondly, vector form, coordinate component form and generalized coordinate form of generalized virtual displacement principle of deformed object are given; thirdly, as the application of the principle, the virtual displacement principle of deformed objects in plane polar coordinate system, space cylindrical coordinate system and spherical coordinate system is given; finally, a brief conclusion is drawn. This work unifies the virtual displacement principle of elastic object, plastic, elastoplastic etc deformed object systems and rigid object systems with the basic method of analytical mechanics. It is a basic principle for dealing with the static problems of deformed objects. This work also lays a foundation for the further study of the dynamics of deformed object systems.
Developing a Tool for Calculating the Carbon Footprint in SMEs
Authors: Eleftheriadis Iordanis , Anagnostopoulou Evgenia
Published: June 2023

Abstract: The need to rapidly reduce GHG has accelerated the adoption of circular models of production. However, this has proved to be a challenging task for SMEs, who lack the financial, organizational and informational capabilities to implement circular business models. In this context, calculating the carbon footprint (CF) of their products could provide the basis for assessing the different circular economy (CE) practices. The aim of this study is to present a CF calculation tool that can be used to calculate the CF of SMEs. The design of the tool was based on the Life Cycle Assessment (LCA) methodology, taking into account the various barriers that SMEs face in adopting CE practices. The tool was tested in a small cheese factory in northern Greece. The pro-duction process was mapped, a GHG inventory was created and the total emissions related to the production of a specific product was estimated. The final aim is to test this tool at a large scale.
Analysis of Judiciary Expenditure Due to Productivity Using Machine Learning Techniques
Authors: Vasconcelos Fernando Freire , Sátiro Renato Máximo , Fávero Luiz Paulo  Lopes , Bortoloto Gabriela Troyano , Lima Hamilton Corrêa
Published: June 2023

Maintaining the judiciary's power requires a high level of budgetary expenditure, but the specifics of this relationship have yet to be fully explored. Although several studies have analyzed the impact of spending in the judiciary through productivity and performance-related measures, none have employed machine learning techniques. This study examines the productivity of the judiciary based on spending and other variables using machine learning techniques, including clustering and neural networks. The final neural network model supports the results of Pearson's parametric correlation test, which found no significant correlation between expenditure and productivity. This study's findings demonstrate the importance of understanding that increased public budgetary expenditure alone is insufficient for improving the judiciary's efficiency. Instead, other administrative and technical measures are necessary to meet the demands of the Brazilian judiciary and improve service delivery rates. These findings offer important theoretical and managerial contributions to the field.
A New RSA Variant Based on Elliptic Curves
Authors: Boudabra Maher , Nitaj Abderrahmane
Published: June 2023

We propose a new scheme based on ephemeral elliptic curves over the ring Z/nZ where n=pq is an RSA modulus with p=up^2+vp^2, q=uq^2+vq^2, up≡uq≡3(mod4). The new scheme is a variant of both the RSA and the KMOV cryptosystems. The scheme can be used for both signature and encryption. We study the security of the new scheme and show that is immune against factorization attacks, discrete logarithm problem attacks, sum of two squares attacks, sum of four squares attacks, isomorphism attacks, and homomorphism attacks. Moreover, we show that the private exponents can be much smaller than the ordinary exponents for RSA and KMOV, which makes the decryption phase in the new scheme more efficient.
Fight the Fire: Association of Cytokine Genomic Markers and Suicidal Behavior May Pave the Way for Future Therapies
Authors: Gonda Xenia , Serafini Gianluca , Dome Peter
Published: June 2023

The fight against suicide is highly challenging as it may be one of the most complex and at the same time most threatening among all psychiatric phenomena. In spite of its huge impact, and despite advances in neurobiology research, understanding and predicting suicide remains a major challenge for both researchers and clinicians. To be able to identify those patients who are likely to engage in suicidal behaviors and identify suicide risk in a reliable and timely manner, we need more specific, novel biological and genetic markers/indicators to develop better screening and diagnostic methods, and in the next step to utilize these molecules as intervention targets. One such potential novel approach is offered by our increasing understanding of the involvement of neuroinflammation based on multiple observations of increased proinflammatory states underlying various psychiatric disorders including suicidal behavior. The present paper overviews our existing understanding of the association between suicide and inflammation including peripheral and central biomarkers, genetic and genomic markers, and our current knowledge of intervention in suicide risk using treatments influencing inflammation, also overviewing the next steps to be taken and obstacles to be overcome before we can utilize cytokines in the treatment of suicidal behavior.
MCAK Inhibitors Induce Aneuploidy in Triple Negative Breast Cancer Models
Authors: Smith John C , Husted Stefan , Pilrose Jay , Ems-McClung Stephanie C , Stout Jane R , Carpenter Richard L , Walczak Claire E
Published: June 2023

Standard of care for triple negative breast cancer (TNBC) involves the use of microtubule poisons like paclitaxel, which are proposed to work by inducing lethal levels of aneuploidy in tumor cells. While these drugs are initially effective in treating cancer, dose-limiting peripheral neuropathies are common. Unfortunately, patients often relapse with drug resistant tumors. Identifying agents against targets that limit aneuploidy may be a valuable approach for therapeutic development. One potential target is the microtubule depolymerizing kinesin, MCAK, which limits aneuploidy by regulating microtubule dynamics during mitosis. Using publicly available datasets, we found that MCAK is upregulated in triple negative breast cancer and is associated with poorer prognoses. Knockdown of MCAK in tumor-derived cell lines caused a two- to five-fold reduction in the IC50 for paclitaxel, without affecting normal cells. Using FRET and image-based assays, we screened compounds from the ChemBridge 50k library and discovered three putative MCAK inhibitors. These compounds reproduced the aneuploidy-inducing phenotype of MCAK loss, reduced clonogenic survival of TNBC cells regardless of taxane-resistance, and the most potent of the three, C4, sensitized TNBC cells to paclitaxel. Collectively, our work shows promise that MCAK may serve as both a biomarker of prognosis and as a therapeutic target.
Quantifying the Potential Contribution of Submerged Aquatic Vegetation to Coastal Carbon Capture in a Delta System from Field and Landsat 8/9-OLI data with Deep Convolutional Neu-ral Network
Authors: Liu Bingqing , Sevick Tom , Jung Hoonshin , Kiskaddon Erin , Carruthers Tim
Published: June 2023

: Submerged aquatic vegetation (SAV) are highly efficient at carbon sequestration and, despite their relatively small distribution globally, are recognized as a potentially valuable component of climate change mitigation. However, SAV mapping in tidal marshes presents a challenge due to optically complex constituents in the water. The emergence and advancement of deep learn-ing-based techniques in the field of habitat mapping with remote sensing imagery provides an opportunity to address this challenge. In this study, an analytical framework was developed to quantify the carbon sequestration of SAV habitats in the Atchafalaya River Delta Estuary from field and remote sensing observations using deep convolutional neural network (DCNN) tech-niques. A U-Net based model, Wetland-SAV Network, was trained to identify SAV percent cover (high, medium, and low) as well as other estuarine habitat types from Landsat 8/9-OLI data. The areal extent of SAV was up to 8% of the total area (47,000 ha) with a significant loss of SAV habitats observed post-Hurricane Barry (~2,300 ha) in 2019. The habitat areas and habitat-specific carbon fluxes were then used to quantify net greenhouse gas (GHG) flux of the study area for with/without SAV scenarios in a Carbon Balance Model. The total net GHG flux was in the range of -0.13 ± 0.06 to -0.86 ± 0.37 ×105 tonne CO2e yr-1 and increased up to 40% (-0.23 ± 0.10 to -0.90 ± 0.39 ×105 tonne CO2e yr-1 ) when SAV was accounted for within the calculation. At the hectare scale, inclusion of SAV resulted in an increase of ~60% for net GHG sink in shallow areas adjacent to emergent marsh where SAV was abundant. This is the first attempt at remotely mapping SAV in coastal Louisiana as well as a first quantification of net GHG flux at the scale of hectares to thousands of hectares, accounting for SAV within these sub-tropical coastal delta marshes. Remote sensing and deep learning models have high potential for mapping and monitoring of SAV in turbid sub-tropical coastal deltas as a component of increasing accuracy of net GHG flux estimates at small (hectare) and large (coastal basin) scales.
Pioneering PGC-1α-Boosted Secretome: A Novel Approach to Combating Liver Fibrosis
Authors: Seo Chang Ho , Na Gun Hyung , Lee Dosang , Park Jung Hyun , Hong Tae Ho , Kim Ok-Hee , Lee Sang Chul , Kim Kee-Hwan , Choi Ho Joong , Kim Say-June
Published: June 2023

Liver fibrosis is a critical health issue with limited treatment options. This study investigates the potential of PGC-Sec, a secretome derived from PGC-1α-overexpressing adipose-derived stem cells (ASCs), as a novel therapeutic strategy for liver fibrosis. Upon achieving a cellular confluence of 70-80%, ASCs were transfected with pcDNA-PGC-1α. PGC-Sec, obtained through concentration of conditioned media using ultrafiltration units with a 3-kDa cutoff, was assessed through in vitro assays and in vivo mouse models. In vitro, PGC-Sec significantly reduced LX2 human hepatic stellate cell proliferation and mitigated mitochondrial oxidative stress compared to control-secretome (Ctrl-Sec). In an in vivo mouse model, PGC-Sec treatment led to notable reductions in hepatic enzyme activity, serum pro-inflammatory cytokine concentrations, and fibrosis-related marker expression. Histological analysis demonstrated improved liver histology and reduced fibrosis severity in PGC-Sec-treated mice. Immunohistochemical staining confirmed enhanced expression of PGC-1α, OPA1 (a mitochondrial function marker), and PPARα (an anti-fibrogenic marker) in the PGC-Sec-treated group, along with reduced Collagen 1A expression (a pro-fibrogenic marker). These findings highlight the therapeutic potential of PGC-Sec in combating liver fibrosis by enhancing mitochondrial biogenesis and function, and promoting antifibrotic processes. PGC-Sec holds promise as a novel treatment strategy for liver fibrosis.
Experimental Research Studies on Seismic Behaviour of Confined Masonry Structures: Current Status and Future Needs
Authors: Perez Gavilán Juan Jose , Brzev Svetlana , Espinosa Cazarin Eric Fernando , Ganzerli Sara , Quiun Daniel , Reiter Matthew T
Published: June 2023

Confined masonry (CM) is a construction system which consists of masonry wall panels enclosed by vertical and horizontal reinforced concrete confining elements. The presence of these confining elements distinguishes CM from unreinforced masonry system and makes this technology suitable for construction of structures in regions subjected to intense seismic or wind actions. CM construction has been used in many countries and regions, and has performed well in past earthquakes. The purpose of the paper is to review past research studies related to the seismic in-plane and out-of-plane behaviour of CM structures. The authors have identified the key design and construction parameters which were considered in past research studies and have performed statistical analyses to establish their influence on the seismic performance of CM buildings. For the purpose of this study the authors have compiled databases of previous experimental studies on CM wall specimens which were used for statistical analyses. Finally, the paper discusses research gaps and needs for future research studies which would contribute to the understanding of seismic behaviour and failure mechanisms of CM walls.
Antimicrobial Susceptibility of Clinical Helicobacter pylori Isolates and Its Eradication by Standard Triple Therapy.
Authors: Alvarez-Aldana Adalucy , Fernandez-Uribe Paula Andrea , Mejía-Valencia Tatiana , Guaca-Gonzalez Yina Marcela , Santacruz-Ibarra Jorge Javier , Arturo-Arias Brenda Lucia , Castañeda-Chavez Luis Javier , Pacheco-López Robinson , Londoño-Giraldo Lina María , Moncayo-Ortiz José Ignacio
Published: June 2023

The current study aims to first, isolate H. pylori in cultures from gastric biopsy samples and test their susceptibility. Secondly, we aim to assess the efficacy of the standard triple therapy from patients coming of the western central region of Colombia. Patients with H. pylori positive re-ceived standard triple therapy with PPI [40 mg b.i.d.], clarithromycin [500 mg b.i.d.], amoxicillin [1g b.i.d.] for 14 days. Thereafter, antibiotic susceptibility of the isolates was assessed by E-Test. From 94 patients enrolled, 67 were positive for H. pylori by histology or culture. Resistance to metronidazole, levofloxacin, rifampicin, clarithromycin and amoxicillin was 81, 26.2, 23.9, 19 and 9.5%, respectively. No resistance was found for tetracycline. 54 patients received standard triple therapy, 48 attended follow-ups testing and of them, 30 had resistance test reports. Overall eradication rate was 81.2%, 4 patients underwent second-line management and only one patient remained H. pylori positive by urea breath test during the follow-up [six weeks]. Eradication was significantly higher in patients with clarithromycin susceptible than in resistant strains [95.6% vs. 42.8% p= 0.001]. The updated percentages of resistance to clarithromycin in this geographical area have increased, so this value must be considered when choosing the treatment regimen.
Human Factors Considerations for Quantifiable Human States in Physical Human-Robot Interaction: A Literature Review
Authors: Abdulazeem Nourhan , Hu Yue
Published: June 2023

As the global population rapidly ages with longer life expectancy and declining birth rates, the need for healthcare services and caregivers for older adults is increasing. Current research envisions addressing this shortage by introducing domestic service robots to assist with daily activities. The successful integration of robots as domestic service providers in our lives requires them to possess efficient manipulation capabilities, provide effective physical assistance, and have adaptive control frameworks that enable them to develop social understanding during human-robot interaction. In this context, human factors, especially quantifiable ones, represent a necessary component. The objective of this paper is to conduct an unbiased review encompassing studies on human factors studied in research involving physical interactions and strong manipulation capabilities. We identified the prevalent human factors in physical human-robot interaction (pHRI), noted the factors typically addressed together and determined the frequently utilized assessment approaches. Additionally, we gathered and categorized proposed quantification approaches based on measurable data for each human factor. We also formed a map of common contexts and applications addressed in pHRI for a comprehensive understanding and easier navigation of the field. We found out that most of the studies in direct pHRI (when there is direct physical contact) focus on social behaviors with belief being the most commonly addressed human factor type. Task collaboration is moderately investigated, while physical assistance is rarely studied. In contrast, indirect pHRI (when the physical contact is mediated via a third item) studies often involve industrial settings, with physical ergonomics being the most frequently investigated human factor. More research is needed on human factors in direct and indirect physical assistance applications, including studies that combine physical social behaviors with physical assistance tasks. We also found that while the predominant approach in most studies involves the use of questionnaires as the main method of quantification, there is a recent trend that seeks to address quantification approaches based on measurable data.
ION PAIR CONVERSION THERMODYNAMICS IN HYDROGEN BROMIDE ALCOHOL SOLUTIONS
Authors: Bulavin Viktor Ivanovich , Vyunnik Ivan Nikolaevich , Rusinov Alexander Ivanovich , Kramarenko Andrii Viktorovich
Published: June 2023

The thermodynamic quantities of dissociation of contact and solvent-separated ion pairs into ions, conversion of contact ion pairs into solvent-separated ion pairs of HBr ionogen in n-alcohols from methyl to n-octyl have been calculated by the procedure we set forth earlier for the HCl – n-alcohol systems in the same solvents at 278.15–328.15 K. The following regularities were established in this work: a) positive values of ΔdisGº of contact and solvent-separated ion pairs increase with increasing temperature, the number of carbon atoms in the n-alcohol molecule, and decreasing radius of halide ion, and their sign and magnitude are determined by the entropic component (–TΔdis Sº). In this case, the values of ΔdisGº of contact ion pairs exceed the same values for solvent-separated ion pairs; b) ΔconvGº values for HCl and HBr are also positive, except for ΔconvGº values in methanol at 278.15–328.15 K and HBr solutions at the same temperatures in ethanol. For these cases, by contrast, ΔdisGº(RIP) > ΔdisGº(CIP) and ΔconvGº are negative. As the temperature and radius of the halide ion increase, ΔconvGº become more negative, and vice versa as the hydrocarbon radical increases; c) the concentration of contact ion pairs increases in the methanol-n-octanol series, decreases slightly with increasing temperature and anion radius, and changes within ~30 % (methanol) to 95 % (n-octanol) at 278.15 K. In methanol, solvent-separated ion pairs predominate; in ethanol, the concentration of both types of ion pairs is approximately the same; in other n-octanols, contact ion pairs predominate.
DEVELOPMENT OF SCIENCE AND LEARNING THROUGH THE PRISM OF THE INTERNATIONAL CONFERENCE ON COMPUTER LINGUISTICS AND COLINS INTELLECTUAL SYSTEMS
Authors: Kupriianov Yevhen , Orobinska Olena , Sharonova Nataliia
Published: June 2023

The present article is devoted to the international scientific conference CoLInS, which has become a platform to exchange the experience and new knowledge in the field of computational linguistics and intelligent systems between scientists, students and graduate students. The purpose of the article is to highlight the role of the conference in improving the educational process and developing scientific thought at the Department of Intelligent Computer Systems. One of the main problems of the conference is the development of intelligent systems designed for natural language processing, which has become particularly relevant in the world of the fact that the process of information exchange between participants in the educational process takes place in a global environment using various applications and instant messengers. In most cases informal learning takes place in social networks, where the exchange of knowledge between participants with different specialized knowledge occurs spontaneously within informal groups and communities of interest. E-learning is perceived by the digital community as the main element of the social progress, which is reflected in the graduate projects of bachelors and masters, as well as masters works in the specialty "Applied and Computational Linguistics". In turn, this affects the formation of the next directions of the subsequent conferences. It is noted that the staff of the Department of ICS takes care of promoting their most significant results of research activities in the educational process and preserving the individual face that exists at the department of the scientific school.
IgG4-Related Spinal Hypertrophic Pachymeningitis With Neurological Deficit
Authors: Tanaviriyachai Terdpong , Chinvattanachot Guntarat , Piyapromdee Urawit , Sirisanthiti Piyaporn
Published: June 2023

Case:

Immunoglobulin G4 (IgG4)-related spinal hypertrophic pachymeningitis (IgG4-RHP) is a rare disease characterized by diffuse inflammatory fibrosis of the spinal dura mater that can cause myelopathy and neurological deficits. Here, we report 2 cases in which both patients presented with myelopathy and paraplegia. They underwent decompressive laminectomy, and the diagnoses were confirmed through histopathologic examination. Both patients received prednisolone postoperatively, which was subsequently switched to methotrexate for maintenance.

Conclusion:

Two cases of IgG4-RHP were successfully treated with decompressive laminectomy and combined therapy with steroids and other immunosuppressive agents.