bluuebunny/crossref_metadata_2025 huggingface dataset:
Une épitaphe inédite de Mustis sur l’administration des domaines impériaux en Afrique du Nord au début du IIe siècle apr. J.-C.
Authors: Chaouali Moheddine
Published: June 2023

In 2011, the epitaph of a man called Marcus Ulpinus Fortunatus was discovered in the necropolis of Mustis. He was a freedman of Emperor Trajan and participated in the management of imperial possessions as a procurator. The name of his wife, Coelia Thallussa, allows us to assume that the couple was of Italian origin. The discovery of the epitaph in Mustis suggests that this city may have housed an administrative service which initially was subordinated to a procurator based in Carthage and to the dismemberment of the imperial administration of the beginning of the second century AD.
Allelopathic potential of litter leachates and aqueous extracts of some understory shrubs of the Mediterranean maquis on the germination of Quercus suber L. / Potentiel allélopathique d’extraits de litière et de quelques espèces du maquis méditerranéen sur la germination des glands de Quercus suber L.
Authors: Benamirouche Samir , Sebti Mohamed , Kaddour Bouchra
Published: June 2023

Cette étude examine la vulnérabilité des glands de chêne-liège (Quercus suber L.) aux composés allélopathiques émis par des espèces communes du maquis méditerranéen. À cette fin, des lessivas de litière et des macéras d’organes aériens de
Former des scientifiques engagés et actifs pour concilier biodiversité et sociétés humaines. De l’état de l’art à la médiation scientifique / Train committed and active scientists to reconcile biodiversity and human societies. From scientific review to mediation
Authors: Corcket Emmanuel , Besson Mathilde , Boswarthick Ryan , Coquin Salomé , Deyna Chloé , Moffa Colin , Santos-Cottin Dorian , Thomé Marie
Published: June 2023

The rapid deterioration of the state of biodiversity on a Mediterranean and planetary scale calls for a global response of ecological transition from our societies. One of the levers identified is to mobilize the higher education community in raising awareness and educating on ecological transition. Scientific mediation is a mean to allow dissemination and appropriation of such scientific issues within society. Moreover, it constitutes a participatory and creative approach, placing the learner at the center of the educational process. To reconcile biodiversity and human societies, and to promote the conservation of emblematic marine and terrestrial vertebrate species, two different scientific mediation actions are presented. In a first case, a board game was designed to better understand the biology and ecology of Mediterranean turtle, shark and cetacean species, to better identify the threats to these populations, and to raise awareness on conservation actions and on scientific studies and monitoring of this threatened fauna. In a second case, a short video was developed to decipher the issues of coexistence of human activities with three predators : the harrier, the fox, and the wolf. In addition to the knowledge of these species, the mediation emphasizes the questions of occupation of territories, zoonosis, and competition for resources to shed light on the conflicts between humans and predators. The development of such a scientific mediation approach constitutes a new challenge for higher education, which finds itself immersed in an unprecedented framework : the ecological emergency that our society is facing.
La conservation des prédateurs : entre enjeux écologiques et conflits socio-économiques / Predator conservation: Ecological concerns and socio-economic conflicts
Authors: Boswarthick Ryan , Deyna Chloé , Moffa Colin , Santos-Cottin Dorian , Thomé Marie
Published: June 2023

We are currently witnessing an exponential growth of the human population and an increased urbanization, leading to many changes in our ecosystems. This leads to humans and predators getting closer, inducing competition for territory and resources, and human-predator conflicts. Three types of conflicts are discussed in this review. The first is the presence of the Montagu’s harrier in crops, which leads to conflicts due to shared territories. The second deals with conflicts caused by the red fox and disease transmission. The last one is on the cohabitation with the gray wolf, illustrating a conflict with human activities in sharing territories and resources.
La Fête des Normands, naissance et épanouissement d’une fête régionale
Authors: Hurard Florian
Published: June 2023

Tous les Normands ne le savent pas encore mais la Normandie a, depuis 2013, sa fête régionale. Célébrée chaque année autour du 29 septembre, jour de la Saint-Michel, cette Fête des Normands semble en train de s’inscrire durablement dans le calendrier festif de la région. Les communes, associations, restaurants, commerces, ou tout simplement les particuliers, sont de plus en plus nombreux à adopter l’événement dans un contexte général marqué par une forte volonté, individuelle et collective, de réappropriation de l’espace commun à toute échelle, notamment régionale. D’où vient la Fête des Normands ? Comment est-elle née ? Où et comment se manifeste-elle ? Quel avenir peut-on envisager pour cette fête régionale naissante ?
Le Havre, le port du futur
Authors: Scherrer Paul
Published: June 2023

Il est régulièrement question du « port du futur » comme s’il pouvait s’agir d’une créationex nihilo. Or le port de demain se construit quotidiennement dans tous les ports du monde sur la base du port d’hier, en prenant notamment en compte les relations qui se sont établies avec les clients tant maritimes que terrestres, pour autant que les autorités portuaires aient une vision suffisamment stratégique et claire de leur avenir.
Les G.I. et l’expérience au feu, les comportements des combattants face à la mort
Authors: Dehays Antonin
Published: June 2023

Inhérente au combat, la peur éprouvée par les soldats américains au cours de la bataille de Normandie, entre le 6 juin et le 21 août 1944, s’est traduite dans les faits par une multitude de comportements permettant au chercheur de mesurer le degré d’inquiétude face à la mort. Parmi les nombreux signes indicateurs de la peur de mourir, le refus de combattre nous interpelle car il met en lumière une prise de conscience progressive, de la part des combattants, de leur vulnérabilité au feu. N’étaient-ils pas tout simplement des hommes arrachés à la sphère civile, trop peu préparés à faire face aux horreurs quotidiennes de la sphère guerrière ? C’est l’enseignement que l’on peut tirer de « l’étude de cas » ci-dessous.
Bourgs et petites villes en Normandie : des laboratoires pour l’avenir ?
Authors: Bergel Pierre , Brouard-Sala Quentin
Published: June 2023

Cet article vise à montrer l’importance des bourgs et des petites villes dans le système urbain normand, bien que ces petites agglomérations présentent des profils très diversifiés. Des politiques publiques originales y sont cependant à l’oeuvre depuis quelques années. Elles démontrent que dynamisme et «créativité » ne sont pas l’apanage des seules métropoles.
Brexit, Espace Manche et Normandie
Authors: Buléon Pascal
Published: June 2023

Le Brexit a retenti comme un coup de tonnerre dans le ciel de l’Europe en juin 2016, mettant un coup d’arrêt à l’intégration de la Grande-Bretagne dans l’espace européen, amorcée dans les années 1970. La négociation de sortie a commencé en juin 2017, elle sera longue. On est bien loin d’en connaître tous les contours et surtout l’aboutissement. Néanmoins, il est possible de réfléchir aux trajectoires possibles que l’Espace Manche et une de ses régions, la Normandie, peuvent prendre sous les répercussions de cet événement de divergence majeure.
Nucléaire en Normandie : une page d’histoire à tourner…
Authors: Marignac Yves
Published: June 2023

Plus que de nombreuses régions françaises, la Normandie a vu son histoire récente façonnée par l’industrie nucléaire, avec des installations parmi les plus emblématiques. Si ce demi-siècle d’histoire a sans doute contribué à l’essor économique de la région, il laisse aussi un héritage de plus en plus controversé. Surtout, à l’heure où le nucléaire français traverse une crise sans précédent et où la transition énergétique est engagée en France et en Europe, la question se pose pour la Normandie d’une forme de reconversion.
Éolien en mer : projets prometteurs contre opposants «vent debout» !
Authors: Orange Gérald
Published: June 2023

La messe est presque dite ! Sauf surprise, il faudra cependant attendre au mieux 2020 pour que les trois sites éoliens offshore – Courseulles-sur-Mer, Fécamp et Dieppe-Le Tréport – produisent de l’électricité. La France est en retard dans la production d’énergie renouvelable. Elle affiche même une production nulle à ce jour pour l’éolien en mer alors que plus de 3 600 éoliennes tournent dans le monde sur 73 parcs offshore ! L’écart est abyssal vis-à-vis de nos voisins du nord et particulièrement de la Grande-Bretagne qui dispose de loin du plus grand parc... Où l’on pourrait penser que l’éolien marin, malgré sa nécessité législative apparue tardivement, a été en partie victime du labyrinthe réglementaire et de la lourde procédure de démocratie participative !
Rire, sourire et humour dans les contes et nouvelles de Maupassant
Authors: Grandadam Emmanuelle
Published: June 2023

Si, globalement, l’humour déserte des romans comme Une vie, Pierre et Jean et Notre Coeur et si «La Parure» et «Le Horla», les contes les plus lus, ne donnent pas l’image d’un Maupassant champion de l’hilarité, son sens de l’humour, cependant, éclate dès «Boule de suif» . Véritable boule de cristal, on y lit d’emblée ce mélange subtil de cruauté et d’humour qui dénonce la victoire des «honnêtes gredins» prêts à toutes les bassesses pour satisfaire leurs petits – et gros – intérêts. Maupassant, de pair avec la conscience tragique qu’il développe, jongle dans nombre de récits brefs – le souffle court est plus propice au rire – avec tous les registres comiques, prenant un malin plaisir à débusquer nos ridicules, nos travers, nos turpitudes, ou à jouer avec nos fantasmes.
L’humour d’Hector Malot
Authors: Alix-Leborgne Viviane
Published: June 2023

Essentiellement connu par ses romans traitant de l’enfance, et particulièrement de l’enfance malheureuse, Hector Malot (1830-1907) est également l’auteur d’une soixantaine d’ouvrages aux thèmes généraux et variés. La politique et les institutions, la religion et la société sont ainsi observées, sans en ménager les travers, les excès, voire l’absurdité. La composition, le ton adopté et la langue révèlent alors une distance et un sens de la dérision propres à l’humour et à l’ironie. De sorte que l’écrivain indulgent, bienveillant, compatissant au malheur des faibles, interroge tacitement le lecteur, avec un sourire retenu, sur ses habitudes de pensée et sa faculté de jugement.
L’aménagement de la Seine normande
Authors: Chaïb Jérôme
Published: June 2023

La Seine semble être aujourd’hui un long fleuve tranquille même si ses débordements à répétition sont encore cause d’inquiétude pour ses riverains. Elle nous rappelle qu’elle fut sauvage, pas totalement assagie, et que sa domestication appartient à un passé récent. Des moyens énormes ont été mis en oeuvre à une époque où la technologie était encore balbutiante. En à peine un siècle, l’histoire d’un fleuve tumultueux pendant six millions d’années a entièrement été gommée. Invitation à un voyage rétrospectif pour mieux comprendre le rôle de l’aménagement de la Seine dans ses enjeux futurs.
L’activité aéronautique du constructeur cherbourgeois Félix Amiot en Normandie (1923-1940)
Authors: Lecarpentier Justin
Published: June 2023

Le nom de Félix Amiot (1894-1974) reste célèbre dans la région et particulièrement à Cherbourg, ville dont l’un des boulevards porte son nom depuis 1976. Ce dernier longe d’ailleurs les installations des Constructions mécaniques de Normandie, chantier naval que fonda Félix Amiot au sortir de la Seconde Guerre mondiale ; c’est d’ailleurs pour son investissement dans la construction navale que l’industriel cherbourgeois reste dans les mémoires, occultant sa première passion et sa «première vie» pour l’aéronautique, qui, bien qu’elle se déroulât majoritairement en région parisienne, connut de nombreuses expressions sur l’ensemble de la Normandie pendant l’entre-deux-guerres.
Focus – technologie militaire en Normandie : Naval Group, Thales
Authors: Morvan Alain , Eudeline Philippe
Published: June 2023

Comptant 3 300 collaborateurs, le site Naval Group de Cherbourg (Manche) est l’unique industrie française entièrement dédiée à la conception et à la construction de sous-marins. Sur 50 hectares, il concentre des expertises et moyens uniques en Europe, permettant la réalisation d’un des produits parmi les plus complexes au monde.
Le cidre normand, une légende dorée
Authors: Chaïb Jérôme
Published: June 2023

Normandie et cidre sont devenus indissociables. Pourtant, ce n’est pas en Normandie qu’on en produit ou consomme le plus. Dorée comme le cidre qui pétille dans les verres, une légende est née autour de cette boisson, usurpée au départ. Les cidres ont su heureusement se hisser, ces dernières années, à un niveau d’excellence jamais atteint dans leur histoire. Il a fallu frôler la catastrophe pour qu’en une trentaine d’années une révolution salutaire s’opère dans la production cidricole.
Pommes et cidres en transformation au Québec
Authors: Cloutier L. Martin , Renard Laurent , Arcand Sébastien , Roche Yann
Published: June 2023

Depuis la fin des années 1980, les cidres québécois sont des boissons à valeur ajoutée. Grâce à l’introduction du cidre de glace, un produit à l’origine artisan et haut de gamme, et à la commercialisation de cidres effervescents, le cidre a surtout été positionné à la manière vitivinicole. Les tendances récentes montrent que la transformation et la consommation des cidres au Québec s’inscrivent désormais, à l’instar de la mouvance cidricole nord-américaine, dans un positionnement marchand à la manière brassicole.
Get Started or Unstuck: Four Elements of Successful Interdisciplinary Collaboration in Extension
Authors: Holland Alison , Troschinetz Alexis , Missaghi Shahram
Published: June 2023

Minnesota Extension needs to increase interdisciplinary collaboration across the organization to remain successful. Through interviews with associate deans and Extension educators, we investigated elements of existing interdisciplinary collaboration and recommended ways to approach such collaborations. Common themes identified were (a) the need to identify an issue requiring collaboration, (b) the need to define success, (c) the need to clarify expectations, and (d) the need to determine resources. Our findings can help Extension professionals get started, or unstuck, in the pursuit of successful interdisciplinary collaborations.
Unlocking the Potential of Older Adult Volunteers: The Intergenerational Leadership Institute Model as a Resource for Bolstering Extension
Authors: Kaplan Matthew , Junkermeier Heather , Bradley Leah
Published: June 2023

The Intergenerational Leadership Institute (ILI) is a yearlong certificate training program developed by Pennsylvania State University for older adults (55-plus) seeking new lifelong learning and civic engagement experiences and opportunities to contribute to innovation and change in their communities. Data from participant surveys and observations of ILI-related training and program planning sessions indicate growth in participants' intergenerational programming and leadership skills in the context of translating intervention ideas into concrete plans and programs. This article describes the process and outcomes of ILI chapters in State College, Pennsylvania, and Montgomery County, Maryland, and tools and resources for assisting with program dissemination.
Personal Connections: What Women in Sustainable Agriculture Value in Their Professional Development
Authors: Powell Maud , Fery Melissa , Agenbroad Ariel , Guzy Michael
Published: June 2023

We designed a national sustainable agriculture conference for women farmers and agricultural professionals to provide a supportive environment in which participants felt comfortable to learn, share, contribute, question, network, and make connections affecting their personal and professional lives. Through postconference and later retrospective evaluations, we identified key concepts that Extension professionals and others hosting agricultural events may consider when engaging women participants. Women in sustainable agriculture may prioritize choosing a conference, and are more likely to participate fully, when it is women focused. Women appreciate hands-on experiences and learning from experts and peers but value most the opportunity to connect with other women in similar circumstances.
Visual-Based Minimal-Text Food Safety Training Tools for Chinese-Speaking Food Service Workers
Authors: Rajagopal Lakshman , Reynolds Joel , Li Dawei
Published: June 2023

This article describes visual-based minimal-text food safety tools developed in Mandarin Chinese to educate Chinese-speaking food service workers about safe food handling practices. Ten posters and one PowerPoint presentation were developed, and their efficacy in conveying critical food safety messages was tested with Chinese-speaking food service workers in Iowa. Extension educators can use these tools for formal and informal food safety education, thereby contributing to protecting public health.
The association between hyperuricemia and the risk of acute kidney injury; a systematic review and meta-analysis
Authors: Rezaei Mohammad Reza , Khaledi Mohamad , Rezaei Bareza , Farnia Mohammad Reza , Rafiei Hooman , Moradi Samira , Karami Pegah , Gharebakhshi Farshad , Fattahi Farinaz
Published: June 2023

Introduction: Acute kidney injury (AKI) is a prevalent clinical syndrome in hospitalized patients associated with uric acid levels in patients. This study aims to evaluate the relationship between hyperuricemia and the risk of AKI using a systematic review and meta-analysis approach. Materials and Methods: This systematic review and meta-analysis was performed based on PRISMA guidelines. A query on international databases, including Cochrane, Web of Science, PubMed, Scopus, and the Google Scholar search engine, was conducted using relevant keywords. The literature search stage was updated until January 2023. Data were analyzed in STATA 14 software. A significance level of P < 0.05 was considered for all tests. Results: A total of 22 articles published from 2006 to 2023 with a sample size of 82469 patients were reviewed. The estimated odds ratio (OR) was 1.96 (95% CI: 1.63, 2.35, P=0.000, I2=89.6%) between hyperuricemia and the risk of AKI and 1.64 (OR: 1.64; 95% CI: 1.23, 2.20, P=0.012, I2=63.2%) between hyperuricemia and AKI mortality and these relationships were statistically significant. In addition, the OR of hyperuricemia and AKI was 1.96 (95% CI: 0.97, 3.98, P=0.000, I2=97.9%) in males and 2.34 (OR: 2.34; 95% CI: 1.14, 4.78, P=0.000, I2=97.9%) in females. The OR of hyperuricemia and AKI was 1.07 (95% CI: 1.03, 1.10) in 30-39 years, 2.37 (95% CI: 1.04, 5.42) in 40-49 years, 4.71 (95% CI: 1.29, 17.20) in 50-59 years, 2.07 (95% CI: 1.58, 2.71) in 60-69 years, and 1.42 (95% CI: 1.04, 1.93) in 70-79 years age groups. Conclusion: Hyperuricemia significantly increases the risk of AKI and mortality. Therefore, by reducing the serum level of uric acid, the risks caused by it can be avoided. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO website (ID: CRD42023393648).
Association between type 2 diabetes mellitus and multiple myeloma: Fact or fiction
Authors: Rastegar-Kashkouli Ali , Jafari Mohsen , Karami Saina , Yousefi Pourya , Taravati Amir Mohammad , Khavaran Ashkan , Rastegar Dordaneh , Jafari Mohammad Reza , Alemohammad Seyedeh Yasaman , Dargahi Abbasabad Ghader , Shahbaz Mohammad , Ebrahimi Kalan Mohammad
Published: June 2023

Multiple myeloma is a plasma cell cancer causing bone and marrow damage, resulting in hypercalcemia, anemia, and renal insufficiency. Diabetes mellitus occurs in 6-24% of multiple myeloma cases, associated with immunosuppression, inflammation, and lymphocyte dysfunction, possibly contributing to multiple myeloma development. Insulin and insulin-like growth factor-1 also contribute to multiple myeloma pathogenesis. The incidence of both multiple myeloma and diabetes mellitus is expected to rise due to the aging population, lifestyle changes, genetic predisposition, and improved diagnostic methods. Although the link between diabetes mellitus and hematological malignancy risk is less conclusive, insulin resistance and growth factors may promote tumor cell proliferation. Genetic variants linked to type 2 diabetes mellitus (T2DM) influence multiple myeloma risks. The insulin like growth factor 1 (IGF1) gene triggers malignant plasma cell proliferation. Additionally, poorly managed T2DM-induced acidosis creates a favorable environment for cancer cell growth, including multiple myeloma. T2DM and metabolic syndrome (MetS) increase multiple myeloma risks through insulin resistance, hyperinsulinemia, inflammation, and dyslipidemia. Inflammatory cytokines [interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β)] contribute to insulin resistance, chronic inflammation, and multiple myeloma cell survival too. The coexistence of diabetes and multiple myeloma presents challenges in managing complications like neuropathy, nephropathy, and retinopathy. In conclusion, the association between T2DM and multiple myeloma has been established, with a discernible influence from distinct genetic variations. Notably, IL-6, TNF-alpha, and IL-1β exert significant influence on the development of insulin resistance and the proliferation of cancer cells, and also their viability. Consequently, the involvement of inflammatory cytokines, dyslipidemia, and IGF1 in the progression of MM among patients with T2DM and MetS is noteworthy.
Ebü’l-Velîd el-Bâcî’nin en-Nasîhatü’l-Velediyye Adlı Eseri ve Değerler Eğitimi Açısından İncelenmesi
Authors: GEMİ Ahmet
Published: June 2023

Doğu ile Batı arasında bir köprü konumunda olan Endülüs, İslam kültür ve medeniyetinde önemli bir yere sahiptir. Müslümanların Endülüs’e yerleşmesiyle birlikte burada sosyal, kültürel ve ekonomik olarak büyük bir gelişme yaşanmıştır. Bu gelişmenin etkilerini günümüzde birçok alanda görmek mümkündür. Bu ilerlemenin bir sonucu olarak bölgede Arap dili ve edebiyatı da gelişme göstermiş ve ünü günümüze kadar ulaşan birçok Endülüslü âlim yetişmiştir. Bu âlimlerden biri, Endülüslü edip ve şair Ebü’l-Velîd Süleymân b. Halef b. Sa‘d et-Tücîbî el-Bâcî’dir. el-Bâcî, farklı alanlarda eser kaleme almıştır. Zahiriyye mezhebinin büyük temsilcisi, meşhur İbn Hazm’ın çağdaşı olan el-Bâcî, daha çok fıkıh, hadis ve edebiyat alanında ön plana çıkmıştır.
el-Bâcî, en-Nasîhatü’l-Velediyye adlı edebi bir eser kaleme almıştır. İki çocuğuna yaptığı nasihatleri barındıran bu eser, önemli bir nasihatname olup günümüze kadar ulaşmıştır. Değerlerin sonraki kuşaklara aktarılmasında nasihatlerin önemi büyüktür. Bu çalışmada değerlerin nesilden nesile aktarılmasında bir köprü görevi gören nasihat/nasihatname geleneği ve günümüz çocuk eğitimindeki yeri üzerinde durulmuştur.
Environmental improvement to reduce urban vulnerability in irregular settlements
Authors: ACOSTA-MUÑOZ Mauricio Diego , FLORES-LUCERO María de Lourdes , GUEVARA-ROMERO María Lourdes
Published: June 2023

The peripherals illegal settlements in Puebla, have common denominator to born in a situation of urban vulnerability, it means with a lack of infrastructure and basic services and on some occasions on land not suitable for urbanization. This is the case of the Cuitláhuac neighborhood where approximately 400 inhabitants live. The neighborhood only has electricity service, his high urban vulnerability becomes worst in the rainy season with the formation of gullies, flooding sites and soil erosion, affecting the mobility of the inhabitants. Authorities ignore these problems and not always included them in urban development plans. The objective of research is to look for environmental alternatives to reduce urban vulnerability in illegal settlements. The methodology is based on action research and the main techniques were: documentary review, physical and virtual field trips, virtual meetings and semi-directed interviews. A relevant conclusion is that green infrastructure is feasible and can be implemented in the short term and that it arouses much collaborative interest from the inhabitants both for its implementation and for its maintenance.
Recent Advancements in Fisheries Systems and Applications for Animal Growth in Water-Borne Animals Fisheries Systems
Authors: Nadir Nabeela , Samra Saima , Maqbool Ayesha , Tariq Noshin , Javed Muhammad Sheeraz , Raheel Syed Muhammad Moeen uddin , Nazir Kiaenat , Aslam Huzaifa , Mansha Muhammad Tamoor
Published: June 2023

Advances in fisheries system have been made in the few past years due to different technological progress in the food chain system by improving the mutual communication among different types of organisms. Overfishing, anthropogenic climate change, and pollution are already having measurable impacts on the marine environment throughout the majority of the globe, and their potential long-term repercussions are very concerning. Fishing activity contributes to marine debris; the proportional contribution of recreational fishing has not been quantified. New approaches that are being used in various ways include the precautionary approach, the ecological approach, adaptive management, and harvest control rules. Growth in coastal population has made water and land pollution worse and placed additional pressure on coastal development. Satellite remote sensing has been an essential tool in fishery research, management, and harvesting because it offers synoptic ocean measurements for evaluating environmental influences on the abundance and distribution of fish populations and allows ecological analyses at community and ecosystem scales. Synthetic super-active analogues with higher inducing potency at lower doses were developed using biotechnological techniques including protein engineering and recombinant DNA technology. There are many methods of preservation, including as drying, smoking, freezing, chilling, and brining. Fish that has been smoked or dried has more nutrients and is easier to digest. Fish is often prepared by smoking or drying; both processes eliminate moisture by heating, which reduces the development of germs and increases shelf life. Advances in genetic engineering also helpful for improving the new varieties in the fisheries system.
Features of the development of experimental nephropathy in rats during the use of doxorubicin
Authors: Zverev Ya. F. , Motin Yu. G. , Mazko O. N. , Mozgunova N. A. , Motina N. V.
Published: June 2023

BACKGROUND. One of the most frequently reproduced models of NS is doxorubicin (adriamycin) nephropathy in rats. However, the mechanisms of its development remain insufficiently studied, and it is not entirely clear to which form of NS the nephrotoxicity induced by doxorubicin should be attributed.

THE AIM. Reproduction of doxorubicin nephropathy in rats in an attempt to morphologically identify the resulting pathology and determine the role of free radical oxidation (FRO) in the development of this model of nephrotoxicity.

MATERIALS AND METHODS. Nephropathy was reproduced by a single intravenous administration of doxorubicin to male Wistar rats. In the urine, the content of creatinine, daily proteinuria, and albumin release were determined. Histological examination of the kidneys was performed using a Libra 120 electron microscope (Carl Zeiss, Germany). The total prooxidant activity, total antioxidant activity, the concentration of thiobarbiturate-reactive products, and the activity of antioxidant enzymes were assessed in the blood and kidney.

RESULTS. Against the background of a gradual decrease in the glomerular filtration rate, a significant consistent increase in protein excretion was recorded, largely due to an increase in albumin excretion. Electron microscopic examination revealed a decrease in the number of small (foot) processes of podocytes, their fusion, sclerotic lesions of the elements of the capillary glomerulus, thinning of the GBM, sclerosis of the interstitium. There was a sharp activation of blood OPA and an increase in the content of TBRP. At the same time, such fast-responding antioxidant enzymes as CAT and SOD were activated. The blood TAA decreased in parallel with the decrease in GPO activity.

CONCLUSION. Intravenous administration of doxorubicin to rats induced the development of toxic kidney damage with signs of NS. A characteristic indicator was the development of PU against the background of a decrease in GFR from day 5 and increased many times by the end of the observation period. The greatest contribution to the development of PU was made by an in-crease in albumin excretion. Morphological examination of the kidneys using electron microscopy made it possible to conclude with a high degree of probability that the developed pathology and FSGS are similar. At the same time, FRO activation was recorded, which was expressed in a sig-nificant pro-oxidant effect and a significant decrease in the antioxidant activity of the blood.
The role of stress reactions in the genesis of menstrual cycle disorders in recurrent urinary tract infections in minors
Authors: Chebotareva Yu. Yu. , Letifov G. M. , Petrov Yu. A.
Published: June 2023

BACKGROUND. Extragenital diseases, including recurrent urinary tract infections, have an adverse effect on the reproductive health of children and adolescents. Vaginitis and menstrual cycle disorders, including primary oligomenorrhea, predominate in the structure of gynecological morbidity of minors suffering from recurrent UTIs.

THE AIM: to study the role of stress reactions in the genesis of various variants of menstrual cycle disorders in minors suffering from recurrent UTIs to improve the dispensary management of this cohort of patients.

PATIENTS AND METHODS. A prospective study was conducted in 98 adolescent girls aged 16 to 18 years. Taking into account the nature of the clinical course of UTI, all the subjects were divided into 3 groups: group 1 (n=41) – patients with UTI; group 2 (n=27) patients with frequent recurrence of UTI (more than 3 times a year (rIMP); group 3 (n=30) – minors, 1, 2 health groups with no IPM episode. A specialized gynecological examination, functional diagnostic tests, ultrasound examination of the placemark and ovaries, determination of cortisol, norepinephrine, adrenaline by enzyme immunoassay were carried out. Statistical analysis was performed using the program "SPSS Statistics 17.0 for Windows".

RESULTS. Anovulation was observed in patients with frequent recurrence of UTI. Copious and prolonged menstruation, uterine bleeding and primary oligomenorrhea were observed only in patients with recurrent UTIs. In this cohort, inflammatory gynecological diseases take a chronic course. Polycystic ovarian syndrome (40.7 %) and chronic salpingoophoritis (44.4 %) were often detected in patients with frequently recurrent UTI. In patients suffering from UTI, in contrast to the data of the comparison group, there were significant violations of the nature of adaptive reactions, and changes in antistress reactions and their levels differed depending on the variant of the course of the microbial-inflammatory process. In patients with rare relapses of UTI, antistress reactions of a high level of reactivity prevailed, but there were reactions of calm and increased activation, training that took place at low levels of reactivity.

CONCLUSION. Adaptive-compensatory disorders were revealed in almost every patient with recurrent UTI. Considering that stress is especially pathogenic during puberty, when hormonal and psychophysiological restructuring of the body occurs, prevention and complex therapy of microbial-inflammatory diseases of the urinary system in this category of patients should be carried out taking into account the formation of reproductive function and the severity of adaptation reactions.
PMSM Speed Control using SVPWM Technique
Authors: Rajasekar S. , Supriya M. , Naresh P. , Devaraj R. , Kavya J.
Published: June 2023

A simulation analysis of a voltage source inverter using Space Vector Pulse Width Modulation (SVPWM) to control the speed of a Permanent Magnet Synchronous Motor (PMSM) has been presented in this research. PMSM is an AC drive that widely helps in high power propulsion systems. SVPWM is one of the best PWM techniques. The SVPWM is powered by a voltage source inverter connected to the PMSM. Space vector modulation is responsible for developing pulses to control the switches of the inverter. This research introduces an SVPWM-fed three-phase voltage source inverter for controlling the speed of PMSM drives using MATLAB/Simulink.
Meningkatan Hasil Belajar Biologi pada Materi Sistem Gerak Melalui Model Pembelajaran Kooperatif Tipe Make A Match pada Siswa Kelas XI IPA
Authors: Kurniati Lia
Published: June 2023

Model pembelajaran kooperatif tipe Make a Match merupakan model pembelajaran yang digunakan untuk mengevaluasi hasil belajar siswa dengan menggunakan kartu soal dan kartu jawaban sehingga membangkitkan semangat belajar siswa. dengan tujuan 1) mendeskripsikan penerapan pembelajaran kooperatif tipe Make a Match sehingga dapat meningkatkan hasil belajar, 2) Untuk meningkatan hasil belajar siswa pada materi sistem gerak melalui penerapan pembelajaran kooperatif tipe Make a Match di kelas XI SMA Negeri 1 Pangkalan Susu. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) Metode pengumpulan data dilaksanakan dalam dua siklus dengan tahapan tiap siklus adalah perencanaan, tindakan, observasi/evaluasi dan refleksi. Subjek penelitian ini adalah siswa kelas XI MIPA 1 SMA Negeri 1 Pangkalan Susu yang yang berjumlah 34 orang terdiri dari 18 orang siswa laki-laki dan 16 orang siswa perempuan. Hasil analisis data pada siklus I dan II secara berturut menunjukkan bahwa 1) siswa yang aktif dan bersemangat selama kegiatan berlangsung sebanyak 21 orang (61,76%); 25 orang (73,52%). 2) siswa yang bekerjasama dengan teman sebanyak 20 orang (58,82%); 23 orang (67,64%); 3); siswa yang dapat memasangkan kartu dengan benar sebanyak 16 orang (47, 05%); 25 orang (73,52%); 4) siswa yang mampu memberi pendapat/ide 8 (23,52%) 12 orang (35,29%); 5) siswa yang dapat mengkoreksi kartu yang salah sebanyak 10 (29,41%) 10 orang (29,41%). Perolehan nilai rata-rata tes hasil belajar kelas XI MIPA 1 SMA Negeri 1 Pangkalan Susu dengan menerakan model pembelajaran Make a Match Pada Siklus I sebanyak 22 orang atau 64,70% dan Pada Siklus II sebanyak 29 orang atau 85,29%.
Etiological diagnosis of acute drug contact allergic reaction occurred during ophthalmic surgery
Authors: Vorzheva Irina I. , Barachtenko Irina V.
Published: June 2023

Drug allergy is one of the most common problems in clinical medicine including ophthalmology. The frequency and severity of drug-induced eye lesions continuously increase as the arsenal of active drugs increases.
Among the common causes of eye contact allergy, along with traditionally noted antibiotics and anesthetics, an expanded list of the most remarkable drug allergens, including mydriatics (tropicamide and phenylephrine), beta blockers, dorzolamide, latanoprost, and topical corticosteroids, have been registered recently. In addition to active ingredients, ophthalmic preparations contain various auxiliary substances, such as benzalkonium chloride, chlorhexidine, and thiomersal, which possess sensitizing properties.
This study presents a clinical case of a patient suffering from cataracts who developed an acute local allergic reaction during the introductory period of lens replacement surgery, resulting in the cancelation of surgical intervention. In addition, several drugs are used simultaneously, each of which can cause allergies and excipients in their composition. Approaches to specific diagnostics including the choice of skin tests are described depending on the clinical phenotype of drug allergy. After determining the cause of allergy, recommendations are given to the patient and ophthalmologist for further treatment, enabling the subsequent performance of the operation without complications.
MATHEMATICAL MODEL OF DIAGNOSTIC BEARING ASSEMBLY OF HUB OF STEERING AXLES OF WHEEL TRACTORS OF DRIVING CLASS 1,4
Authors: Borysiuk Dmytro , Tverdokhlib Igor , Kupchuk Ihor , Polievoda Yurii
Published: June 2023

The machine-tractor fleet of enterprises is an important link in the production of products of various branches of industry in Ukraine. The timely performance of transport, agricultural, road construction and other works, and ultimately the cost of products or services, largely depend on its effective work.
Rolling bearings are one of the most common technical devices used in machines. They largely determine the reliability and performance of devices.
The resource of the tractor chassis is mainly determined by the resource of the rolling bearings. Defects in the manufacture and operation of bearings affect the vibration signal in different ways and have different diagnostic signs. This makes it possible to identify defects at the stage of their occurrence and predict further development.
In this work, the method of vibrational non-destructive testing is considered when diagnosing the bearing assemblies of the hubs of steered axles of wheeled tractors of traction class 1.4. The mathematical model developed by the authors for diagnosing the bearing units of the hubs of steered axles of traction class 1.4 wheeled tractors is aimed at determining the technical condition of the rolling bearings and allows predicting their possible service life. The developed mathematical model allows you to determine the clearances in the bearings, vibration frequencies and the average value of deformation caused by the load on the bearing depending on the frequency of rotation of the separator and the inner ring of the bearing, the initial contact angle of the rollers in the bearing, the radius of the seat of the roller, the inner diameter of the bearing, the radius of curvature of the bearing. An equation was created to determine the unbalance of the hub of the steered axles and the seating clearance of the bearings.
Pengaruh customer review, customer rating, dan celebrity endorser terhadap minat beli melalui kepercayaan di online shop Shopee
Authors: Firdaus Mukhammad , Aisyah Siti , Farida Eka
Published: June 2023

Shopee is the number 1 marketplace in Indonesia in terms of usage, but lately Shopee is no longer in that position. The aim of this research is to find out and analyze how the influence of Customer Reviews, Customer Ratings and Celebrity Endorsers on Purchase Intention through trust as an intervening variable at Online Shop Shopee. This research is a quantitative research using explanatory research techniques. The sampling was carried out using purposive sampling technique. The population of this research is all Shopee consumers in Malang city with 95 respondents as a sample. The results of this study are (1) Customer reviews have no significant effect on trust, (2) Customer ratings and celebrity endorsers have a significant effect on trust, (3) Customer reviews have no significant effect on purchase intention, (4) Customer ratings and celebrity endorsers have a significant effect on purchase intention, (5) Trust has an effect on purchase intention, (6) Customer reviews have no significant effect on purchase intention through trust, (7) Customer ratings and celebrity endorsers have a significant effect on purchase intention through trust.
HUBUNGAN INKOMPATIBILITAS GOLONGAN DARAH ABO DENGAN KEJADIAN JAUNDICE PADA NEONATUS
Authors: Veneranda Chrisnoventa , Chondro Fransisca
Published: June 2023

Penyakit bayi kuning atau neonatal jaundice atau ikterus adalah satu dari beberapa kelainan yang paling sering terjadi pada bayi baru lahir. Sekitar 60% dari bayi lahir cukup umur atau aterm dan 80% dari bayi lahir prematur mengalami jaundice di minggu pertama kehidupannya. Neonatal jaundice merupakan keadaan dimana terjadi akumulasi bilirubin pada kulit dan membran mukosa bayi baru lahir sehingga terjadi perubahan warna kulit dan sklera. Hal ini disebabkan karena tingginya kadar bilirubin di sirkulasi yang disebut juga hiperbilirubinemia. Keadaan ini dapat disebabkan antara lain oleh inkompatibilitas golongan darah ibu dan anak. Sampai saat ini penelitian berkaitan inkompatibilitas golongan darah ibu dan terjadinya ikterus pada bayi masih memberikan hasil yang kontradiktif. Penelitian ini bertujuan untuk menentukan hubungan antara inkompatibilitas golongan darah ABO dengan kejadian jaundice pada neonatus. Studi ini menggunakan pendekatan analitik observasional dengan desain potong-lintang. Sampel diambil secara consecutive non-random sampling dengan menggunakan data rekam medis bayi baru lahir sebanyak 110 sampel yang diambil dari periode Desember 2020 sampai Desember 2021. Pemilihan responden didasarkan pada kriteria inklusi yakni bayi yang lahir cukup bulan di RS Budhi Asih, dan kriteria eksklusi yaitu bayi yang mengalami asfiksia, hipoksia serta ibu yang mengalami preeklamsia. Didapatkan sebanyak 82% bayi terdiagnosis neonatal jaundice dan terdapat inkompatibilitas golongan darah ABO. Analisis bivariat dengan uji chi square antara inkompatibilitas golongan darah ABO dan kejadian jaundice pada neonatus didapatkan p = 0,002. Didapatkan hubungan yang bermakna inkompatibilitas golongan darah ABO dan kejadian jaundice pada neonatus.
Hod vadisi (Aşağı Maden ve Yukarı Maden, Artvin, Türkiye) memeli hayvan çeşitliliği
Authors: GÖKTÜRK Temel
Published: June 2023

Zengin orman kaynağı ve yaban hayatına sahip olan Artvin ili biyolojik çeşitlilik bakımından Türkiye’nin nadir illerindendir. Artvin ili yer alan Hod vadisinde 2010-2020 yılları arasında yapılan bu bilimsel çalışmada, 15 familyaya mensup 31 memeli türünün varlığı tespit edilmiştir. Türlerin koruma durumları IUCN, BERN ve CITES kriterlerine göre değerlendirilmiştir. Bunlardan Miniopterus schreibersi, Pipistrellus pipistrellus, Nyctalus leisleri, Canis lupus, Ursus arctos ve Capra aegagrus Bern Sözleşmesi Ek 2’de; Sorex minutus, Lepus capensis, Mustela nivalis, Meles meles ve Rupicapra rupicapra Ek 3’te listelenmektedir. Alanda tespit edilen Capra aegagrus IUCN tarafından tehdit altında olarak sınıflandırılmaktadır.
Pengembangan Media Pembelajaran Interaktif Augmented Reality Mata Pelajaran Komputer Dan Jaringan Dasar
Authors: Widaraeni Fitri Sulis , Vivianti
Published: June 2023

Kemajuan teknologi telah memberikan pengaruh besar dalam dunia pendidikan salah satunya yaitu pada media pembelajaran yang semakin bervariasi, salah satu teknologi yang dapat diakses melalui smartphone yaitu Augmented Reality (AR).  Keterbatasan sumber belajar dapat membuat siswa mengalami kesulitan dalam belajar. Sehingga diperlukan sumber belajar dan media belajar yang dapat mendukung pembelajaran. Metode penelitian yang digunakan adalah penelitian dan pengembangan atau Research and Development (R&D) dengan model pengembangan ADDIE yaitu (Analisys, Design, Development, Implementation, Evaluation). Media pembelajaran ini telah layak dan efektif digunakan setelah dilakukan serangkaian pengujian. Pengujian oleh ahli media mendapat nilai rata-rata 83,92% atau dalam kategori sangat layak. Penilaian ahli materi mendapat nilai rata-rata 94,11% atau dalam kategori sangat layak. Penilaian siswa mendapat nilai rata-rata 91,92% atau dalam kategori sangat layak. Berdasarkan ketiga hasil uji kelayakan, maka media pembelajaran ini sangat layak digunakan sebagai alat bantu dalam pembelajaran. Sedangkan dari segi efektivitas media, mendapat nilai rata-rata N-Gain Score 75% atau dalam kategori cukup efektif. Sehingga media pembelajaran interaktif Augmented Reality cukup efektif digunakan sebagai alat bantu pembelajaran dalam meningkatkan hasil belajar siswa.
OPTIMISATION MODEL OF PRODUCTION PROCESSES AS AN EXAMPLE OF THE COSMETICS SECTOR
Authors: Meidutė-Kavaliauskienė Ieva , Činčikaitė Renata , Andrijauskaitė Monika
Published: June 2023

In 2020, Europe reached 76.7 billion people. EUR of cosmetics sales in the retail market and according to this indicator is the largest market for cosmetic products in the world. 500 million European consumers use cosmetics and personal care products every day to protect their health and improve their well-being. With the high demand for cosmetic products, companies must ensure that products are produced at the right time and in the right quantities. However, in cosmetic manufacturing processes, inevitable losses occur in the supply chain and various losses in production that slow the shipments of cosmetic products. Continuous improvement of production processes, cost reduction measures, and quality assurance are necessary measures to obtain maximum profit and remain competitive. The object of the study is to improve production processes in the cosmetics sector. The purpose of the article is to identify the main problems of production processes in the cosmetics sector and to create a model for improving production processes. To achieve the goal, the following tasks are set: perform an analysis of scientific literature related to the improvement of the production process of the cosmetics sector; to choose appropriate research methods that will help identify the problems of improving production processes in the cosmetics sector; to present a model for improving cosmetic product manufacturing processes in cosmetic manufacturing companies. Research methods: analysis of scientific literature, observation method, expert assessment.
INDUSTRY 4.0 TECHNOLOGIES ENABLEMENT IN MARKETING ACTIVITIES OF SMES TO FULFILL CUSTOMERS’ NEEDS FOR PERSONALIZATION: A SYSTEMATIC REVIEW
Authors: Blažinauskytė Evelina , Dikčius Vytautas
Published: June 2023

Over the last few years, a significant number of studies have examined the concept of Industry 4.0 and its impact on business operations. As current business digitalization processes provide a significant opportunity for SMEs to enable the newest marketing tools and customer-oriented approaches, this study aims to investigate the enablement of Industry 4.0 technologies in marketing activities within SMEs for fulfilling customer needs for personalization. The study was based on a systematic analysis of 8 core databases, which generated more than 1400 articles published during 2016–2020. Using PRISMA steps, 50 articles were used for the qualitative content analysis. The findings of this research confirmed that 4th Industrial Revolution technologies enablement impacts all elements of the Marketing Mix and provides the chance to increase customer needs for personalization: it enhances the co-creation opportunities and enables a higher customized shopping experience. This study deepens the understanding of Industry 4.0 technologies’ impact on marketing and identifies potential unexplored research gaps in this area.
ROLE OF NEW TECHNOLOGIES IN LOGISTICS PROCESSES AND EXPANSION OF LOGISTICS ACTIVITY WITH VIRTUAL COMPONENTS
Authors: Demirova Siyka
Published: June 2023

In improving the organizational structure of industrial activities from an information-logistics point of view, the role of the logistics system is extremely important. Therefore, certain requirements must be met when building effective logistics information systems of a higher class. The purpose of the report is to clarify precisely the role of new technologies in logistics processes and the expansion of logistics activity with the help of virtual components to improve the organizational structure of industrial logistics systems with virtual components.