bluuebunny/crossref_metadata_2025 huggingface dataset:
Respon Padi Gogo (Oryza sativa L.) terhadap Pemberian Biostimulan dari Ekstrak Rumput Laut Padina minor
Authors: Noli Zozy Aneloi , Suwirmen Suwirmen , Izmiarti Izmiarti , Oktavia Reza , Aliyyanti Putri
Published: November 2022

Currently, seaweed extracts are widely used as plant biostimulants to increase the efficiency of nutrient use, tolerance of abiotic stress, and improve plant quality. In this study, tested the effect of different Padina minor seaweed extract formulas (liquid extract and powder extract) and the frequency of application of Padina minor seaweed extract (b0 = control; b1 = 1 x application; b2 = 2 x application; and b3 = 3 x application) as a biostimulant to the growth of upland rice. From the results of the study, it was found that there was no significant effect of the application of the two extract formulas and the frequency of application, but the administration of Padina minor extract 3 times during vegetative growth increased all growth parameters, such as: plant height, number of tillers, fresh and dry weight of plants, and chlorophyll content. It was concluded that giving Padina minor extract 3 times could increase the vegetative growth of upland rice effectively.
Implementasi Model Pembelajaran Think Pair Share (TPS) Berbasis Lesson Study untuk Meningkatkan Aktivitas Belajar dan Keterampilan Metakognitif Mahasiswa pada Matakuliah Pengembangan Kurikulum IPA SMP
Authors: Kuswara R. Didi , Ferdiana Suci , Dipalaya Tismi , Sholihah Illiyatus
Published: November 2022

21st century learning is learning oriented to the formation of students who have the skills or skills needed in living the 21st century life, such as being able to communicate and collaborate well and have metacognitive skills. Improving the quality of education is important, one of which is improving the learning process in the classroom by applying learning models that can develop students' abilities. One of them is by applying the Think Pair Share (TPS) cooperative learning model. The purpose of this study was to improve learning activities and metacognitive skills of Biology Education students in the Science Curriculum Development course at SMP Negeri Malang State University. This type of research is Classroom Action Research based on Lesson Study (PTK-LS). The research approach used is descriptive qualitative. The results showed that: 1) the percentage level of the implementation of the Think Pair Share (TPS) cooperative learning model was very good, namely 80%; 2) student learning activities in semester VII have increased by 2.01%; and 3) the metacognitive skills of seventh semester students have increased by an average of 2.26. The conclusion is that the Think Pair Share (TPS) cooperative learning model can improve student learning activities and metacognitive skills.
Analisis Kualitas Air pada Genangan Air Hujan sebagai Konsumsi Hewan Ternak di Desa Teba Timur Kabupaten Timor Tengah Utara
Authors: Santiari Made , Tuas Maria Angelina
Published: November 2022

East Teba Village has limited water availability due to the relatively long duration of the dry season, so the villagers use rainwater puddles for various activities, including consumption (source of drinking water) for livestock. This study aims to determine the quality of water in puddles of rainwater for consumption (source of drinking water) livestock. This research is quantitative descriptive. The sampling point of the test is the point where livestock drink water. Sampling test based on SNI 6989.57:2008 regarding the method of sampling surface water. The test result data is compared with the quality standard and the quality status is calculated using the pollution index method. The results showed that the TSS value had exceeded the class 2 and class 3 quality standards, while the BOD value had exceeded the class 2 quality standard and still met the class 3 quality standard. The parameter index value obtained was 2.20 which was classified as lightly polluted. The water in the puddle cannot be consumed by livestock, because the water does not meet the quality standard based on the calculation of the quality status using the pollution index method.
Perbandingan Pola Rasio Morfometrik dan Karakteristik Habitat Dua Spesies Ikan Wild Betta Asal Pulau Belitung
Authors: Syarif Ahmad Fahrul , Robin Robin , Tiandho Yuant , Gustomi Andi
Published: November 2022

The existence of Wild Betta fish in Belitung Island needs to be studied. This study aims to analyze the differences in the morphology of two species of Wild Betta fish from Belitung Island based on the morphometric characteristics and habitat of these fish. The method used in this research is quantitative descriptive. This research was conducted in freshwater located in Dukong Village, Simpang Pesak District, East Belitung Regency from May to June 2020. The fish samples obtained were 35 fish consisting of 20 Betta uberis fish and 15 Betta edithae fish. The data obtained were analyzed descriptively and presented in graphs or tables. The results showed that the comparison of the morphometric ratio patterns found in the two Wild Betta fish species differed specifically from several characters, including Total Length (PT), Body Length (PB), Tail Length (PE), and Head Height (TK). Meanwhile, based on the ratio of morphometric characters, there are 3 main characteristics, namely: 1) Tail Length (PE) (1.249); 2) Head Length (PK) (0.869); 3) Width Body I (LB-I) (1,126); 4) Head Length (PK) (0.816); 5) Body Width II (LB-II) (0.337); and 6) Body Length (PB) (0.436). The habitat of Wild Betta fish from Belitung Island generally inhabits peat waters with fairly low pH conditions, ranging from 4-5 with the color of the waters that tend to be black to brownish.
Analisis Butir Soal Ujian Akhir Semester Ganjil Biologi Kelas XI MAN 2 Kota Jambi
Authors: Subari Ahmad , Lufri Lufri , Syamsurizal Syamsurizal
Published: November 2022

This study aims to determine the quality of the final exam questions for the odd semester biology class XI MAN 2 Jambi City. The research subjects were 167 students of class XI MAN 2 Jambi City in the 2020/2021 academic year. This research is a descriptive study with data collection techniques through test instruments in the form of multiple choice questions, answer sheets, and answer keys. The data analysis technique used the Anates version 4.0.9 program to determine the reliability, level of difficulty, discriminatory power, distractor quality, and recap of item analysis. The results in this study indicate that the reliability value of the test items is 0.06 with very low criteria. For the item difficulty level, there are 4 questions of "very easy" difficulty, 2 questions "easy", 7 questions "medium", 4 difficult "difficult" questions, and 8 questions "very difficult". On the discriminatory power of items, there are 7 items classified into the "very bad" category, 8 items classified as "bad", 6 items classified as "enough", and 4 items classified as "good". While the results of the analysis of the quality of the item distractors, which have a distractor level of less than 51% which are generally found in each item. In addition, there are very few distractors in the percentage categories (51-75 or 126-150) and 76-125. Therefore, it can be concluded that, overall there are no questions that can be directly used, but some questions must be improved, and the rest cannot be used. There are 11 questions that need to be improved, and the remaining 14 questions that cannot be used.
Pengaruh Penggunaan Limbah Air Cucian Beras terhadap Pertumbuhan Tanaman Seledri (Apium graveolens L.) dengan Sistem Penanaman Hidroponik
Authors: Astija Astija , Anita Anita
Published: November 2022

Rice washing water waste is the result of community waste which in general is no longer used, even though the waste can still be processed and used, one of which is as fertilizer for plants. Therefore, this study aims to determine the effect of the use of rice washing water waste on increasing the growth of celery (Apium graveolens L.) with a hydroponic planting system. The research location is in the Laboratory and Green House of the Biology Education Study Program, FKIP, Tadulako University. The study was carried out experimentally with a completely randomized design (CRD), which consisted of 4 types of treatment and was repeated 4 times. The treatments consisted of: K0 (control) = 0% without giving rice washing water; K1 = 25% of rice washing water waste; K2= 50% of rice washing water waste; and K3 = 75% rice washing water waste. The data obtained were then analyzed using the ANOVA test and a further BNT test was carried out which was processed using the SPSS 25 program. The results showed that the height of celery plants at the age of 10 DAP (Days After Planting), 20 DAP, and 30 DAP, was significantly affected by the treatment. rice washing water waste, although the concentrations were not significantly different between treatments. These results indicate that rice washing water has a significant effect on increasing the growth of celery plants.
Perfil clínico-epidemiológico dos acidentes com animais peçonhentos em uma microrregião de Minas Gerais, Brasil
Authors: Neves Pedro Henrique Moreira , Pereira Vinícius Afonso , Martins Carolina Palmeira Teixeira
Published: November 2022

Os acidentes com animais peçonhentos são agravos de saúde negligenciados, principalmente em países subdesenvolvidos e em desenvolvimento. A subnotificação e sub-registro de informações dificulta a compreensão da real incidência desta morbidade. Assim, o objetivo do estudo é caracterizar o perfil epidemiológico e clínico dos acidentes com animais peçonhentos em uma microrregião de Minas Gerais. Trata-se de um estudo epidemiológico observacional de abordagem quantitativa descritiva e recorte retrospectivo dos acidentes com animais peçonhentos ocorridos na microrregião de Pedra Azul em Minas Gerais de 2017-2020. Ocorreram 1817 acidentes na microrregião no período estudado. O ano de 2018 foi o de maior incidência, com os acidentes distribuídos ao longo dos meses. Comercinho foi o local de maior incidência, e os acidentes ocorreram majoritariamente na zona rural. O escorpionismo foi o acidente mais frequente. As mulheres foram as vítimas mais frequentes, sendo a população economicamente ativa (20-59 anos) a mais acometida. A maioria dos casos foram classificados como leves, havendo apenas 7 óbitos. A maior parte das vítimas foram atendidas em até 1 hora após o acidente, sendo que na maioria não foi administrada a soroterapia. Mãos e pés foram mais acometidos. Assim, destaca-se a importância dos resultados no fortalecimento da vigilância em saúde loco-regionais, bem como no incentivo ao preenchimento e alimentação correta no banco de dados nacional.
Barreiras enfrentadas na assistência humanizada em Unidades de Terapia Intensiva - UTI
Authors: Lima Júnior Djalma Antonio de , Lima Débora de Sousa , Dias Ellen Angélica Ferreira , Ferreira Luciana Coelho , Fontenele Rivaney de Paulo , Oliveira Viviane Cardoso Lima de , Rabelo Neto Antonio , Silva Cleidson Morais
Published: November 2022

O avanço da tecnologia proporcionou melhores condições de tratamento para pacientes graves, porém contribuiu para a mecanização do cuidado. O objetivo deste trabalho é identificar as barreiras enfrentadas pela equipe de enfermagem para a implantação da humanização nas UTIs. Trata-se de um estudo do tipo retrospectivo, descritivo e revisão de literatura do tipo narrativa com busca nas bases de dados eletrônicos LILACS, Pubmed e SciELO. Foram utilizados artigos científicos publicados em língua portuguesa e inglesa, a partir de 2015 que continham o tema descrito. Identificou-se que a desumanização do cuidado é muito presente entre os profissionais da saúde pois existem vários fatores que impedem a execução de uma boa assistência. Como principais fatores foram encontrados a mecanização do cuidado, a dissociação da família, condições de trabalho, implantação do modelo biomédico e dificuldade nas relações interpessoais. A gestão e os usuários também são inclusos na atenção da política de humanização, pois são indispensáveis suas participações nessa mudança. A implementação da PNH se faz necessária a fim da transformação da teoria em prática.
Impacto de um programa de reabilitação pulmonar em pacientes com doenças pulmonares crônicas em um centro de atenção terciária
Authors: Aires Daniel Cutrim , Costa Maria do Rosário da Silva Ramos , Paes Florenir Glória da , Cantanhede Ana Beatriz Santos , Gabriel Dheisson de Almeida , Costa Denes Cutrim , Rocha Savya Cybelle Milhomem
Published: November 2022

Doenças pulmonares crônicas podem determinar limitações nas atividades diárias e qualidade de vida prejudicada. A Reabilitação Pulmonar (RP) consiste em um tratamento integral e individualizado que objetiva melhorar a condição física e psicológica dos pacientes e pode ser empregada no manejo de diferentes pneumopatias. A avaliação da qualidade de vida e da capacidade funcional de exercício de pacientes submetidos à RP permite quantificar o efeito da intervenção e a resposta ao tratamento instituído. Assim, objetivou-se avaliar o impacto de um Programa de Reabilitação Pulmonar (PRP) na qualidade de vida e na capacidade funcional de exercício de pacientes com doenças pulmonares crônicas, buscando determinar presença de Diferença Mínima Clinicamente Importante (DMCI) ao final do período de reabilitação. Trata-se de uma série de casos com delineamento retrospectivo realizado a partir de coleta de dados em prontuários de 37 pacientes com diferentes pneumopatias crônicas submetidos a um PRP entre 2016 e 2019 em um centro terciário de atenção à saúde em São Luís, Maranhão. Observou-se que os pacientes que finalizaram o PRP obtiveram melhora significativa nos resultados do questionário de qualidade de vida Saint George Respiratory Questionnaire (SGRQ) e na distância percorrida no Teste de Caminhada de Seis Minutos (TC6). Neste último, aproximadamente metade (48,6%) dos participantes obtiveram DMCI, representado principalmente pelo grupo de pacientes portadores de Doença Pulmonar Obstrutiva Crônica (DPOC). Concluiu-se que pacientes com doenças pulmonares crônicas submetidos à RP podem obter desfechos clínicos favoráveis, com a melhora da capacidade de exercício e da qualidade de vida.
Mensurando o índice de refletância solar para a superfície de solo
Authors: Ferruzzi Yuri , Souza Samuel Nelson Melegari de , Gnoatto Estor , Nogueira Carlos Eduardo Camargo , Fischborn Marcos
Published: November 2022

O estudo da refletância solar e, por conseguinte do albedo são essenciais para sistemas fotovoltaicos bifaciais para estimar seu desempenho. Para atender a essa necessidade, instalou-se dois piranômetros, um observando a radiação solar direta e outro a refletida, visando desta forma obter dados do albedo do solo, durante a atividade experimental. O albedo da superfície do solo é um fator importante na relação custo-benefício de um sistema fotovoltaico bifacial. Os conjuntos de dados medidos incluem séries temporais de albedo no período mensal e horários, para o período de 2022. Os resultados preliminares indicaram para um solo típico, o Latossolo Vermelho Eutrófico, que apresenta uma textura argilosa a moderada, um valor de albedo de 0,15 com uma incerteza de medição de ±0,02; Os dados visam facilitar a compreensão dos valores de albedo e as características necessárias, tanto para a uso em um projeto fotovoltaico bifacial instalado no local, quanto para a sua análise financeira futura, como para melhor estimar o desempenho e reduzir o risco de implantação dos sistemas.
Agrotóxicos nos alimentos e saúde humana: abordagem biomédica
Authors: Cardoso Pollyana Machado Santos , Fazenda Juliana
Published: November 2022

Os agrotóxicos também são chamados de defensivos agrícolas ou agroquímicos, eles são um conjunto de substâncias produzidas para exterminar ou inibir a proliferação de insetos, ácaros, ervas daninhas, fungos e outros tipos de vida animal ou vegetal que possam prejudicar a produção agrícola. Entre os agrotóxicos mais usados estão as acaricidas, fungicidas, herbicidas, inseticidas e rodenticidas. Sobre a intoxicação direta de seres humanos, pode ser dividida entre dois tipos principais: a aguda ocorre quando o indivíduo é exposto a altas doses das substâncias, já a crônica é de longo prazo, quando a vítima é exposta gradativamente a doses menores das substâncias agrotóxicas. O exame que faz para diagnosticar a fim de identificar a intoxicação por agrotóxicos é o de colinesterase que é um teste laboratorial solicitado com o objetivo de verificar o grau de exposição da pessoa a produtos tóxicos, como pesticidas, inseticidas, herbicidas ou adubos. Descrever a relação dos agrotóxicos provenientes dos alimentos com a saúde humana e o papel do biomédico é o objetivo dessa pesquisa, que foi realizada em revisão sistemática de literatura de base técnica qualitativa. Podendo concluir que a pesquisa realizada ampliou o conhecimento a respeito do uso de agrotóxicos e seus efeitos na saúde humana, com seus impactos nas regiões com maior utilização, e também teve a maior incidência de problemas de saúde agudo e crônico, como má formação fetal de mulheres gestantes, neoplasias, além de doenças subcrônicas, de tipo neurológico e psiquiátrico.
Correlação espacial e tendência temporal das internações hospitalares por aborto no Brasil e regiões, 2012 a 2021
Authors: Gois Marília Souza Alves , Nogueira Marina de Pádua
Published: November 2022

Objetivo: Analisar temporal e espacialmente as internações hospitalares por aborto no Brasil e regiões no período de 2012 a 2021. Metodologia: Estudo ecológico, com dados do Sistema de Informação Hospitalar (SIH/DATASUS) sobre internação hospitalar por aborto no Brasil e regiões de 2012 a 2021. Foram calculadas as taxas de internação hospitalar (TIH) e as Taxas Bayesianas Empíricas Espaciais (TBEE). As TIH foram utilizadas para análise de tendência temporal feita por meio do JoinPoint. As TBEE foram utilizadas para o modelo espacial, por intermédio do Índice de Moran (IM). Resultados: A tendência temporal do aborto por “outras gravidezes que terminam em aborto” foi de diminuição com Variação Percentual Anual – VPA de -0,7%, aberto espontâneo também foi de decréscimo com -3,9% e aborto por razões médicas foi de crescimento com 2,5% ao ano. O Norte foi a única região que apresentou aumento no aborto por outras gravidezes, com 2,6% ao ano, enquanto que por razões médicas o aumento foi de 8,9%. A região Sudeste apresentou predomínio de redução com -2,7% (outras gravidezes) e -4,5% (espontâneo) e Sul com -2,9% (espontâneo) e -3,9% (razões médicas). Na análise espacial foi identificado autocorrelação inversa entre o IDH e RPC e as TBEE de internação. As regiões Sul e Sudeste apresentaram predomínio de municípios com baixas taxas e altos IDH e RPC, enquanto Norte e Nordeste demonstrou altas taxas com baixos IDH e RPC. Conclusão: A tendência temporal foi diversa. O crescimento foi observado no aborto por razões médicas, principalmente no Norte, Nordeste e Centro-oeste. O Sudeste e Sul apresentaram redução. Houve correlação inversa entre os IDH e RPC dos municípios com as TBEE.
Rapid detection of amphibian chytrid fungus Batrachochytrium dendrobatidis using in situ DNA extraction and a handheld mobile thermocycler
Authors: Kamoroff C , Goldberg CS , Grasso RL
Published: November 2022

The amphibian chytrid fungus (Bd) has caused declines and some extinctions of amphibian populations worldwide. Early and accurate Bd detection is essential for management of susceptible anurans. We analyzed the effectiveness of in situ DNA extraction with a handheld mobile quantitative PCR (qPCR) thermocycler to detect Bd on frog skin swabs and in water samples using environmental DNA (eDNA). We collected duplicate eDNA samples and skin swabs from 3 Bd-positive Rana sierrae populations. We processed one set of samples using a field protocol (a handheld thermocycler) and the other half using a standard lab protocol. We detected Bd DNA in all R. sierrae swabbed using both the field and lab protocols. We also detected Bd DNA in eDNA samples at all sites, although the field and lab protocols failed to detect Bd eDNA at separate singular sites; results from the field and lab eDNA protocol did not match. The probability of detecting Bd DNA in the technical replicates was lower for the field protocol than the lab protocol, suggesting the field protocol has lower sensitivity and may not detect low quantities of DNA. Our results suggest that the field extraction protocol using a handheld qPCR platform is a promising tool for rapid detection of Bd in susceptible amphibian populations, yielding accurate results in less than 60 min. However, the applied field protocol may be prone to false negatives when analyzing low-quantity DNA samples such as eDNA water samples or frog swabs with low pathogen loads.
Implications of Elevated Postprandial Glucose and Nutritional Approaches for Postprandial Glucose Management with a Focus on Whey Proteins
Authors: Taylor Jennifer
Published: November 2022

This symposium took place at the 58th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Stockholm, Sweden. The first speaker was John L. Sievenpiper, who discussed the pathophysiology of postprandial hyperglycaemia and how it may impact the risk of cardiovascular disease (CVD), peripheral vascular disease, insulin resistance, and other comorbidities in patients with Type 2 diabetes (T2D). Sievenpiper then reviewed various pharmacological interventions that target postprandial glucose (PPG) and insulin levels, including incretin therapies and α-glucosidase inhibitors, such as acarbose. Data presented showed that a low glycaemic index (GI) diet can improve glycaemic control and reduce cardiometabolic risk factors in patients with Type 1 diabetes (T1D) and T2D. Sievenpiper then presented data on novel non-pharmacological approaches that target PPG, including mulberry leaf (Morus alba L) extract (MLE), which has α-glucosidase inhibitor activity, reducing PPG and insulin responses to sucrose. The second speaker, Bo Ahrén, presented data on the effects of whey protein (WP) and branched-chain amino acids (BCAA) on PPG management and as a potential intervention for postprandial hyperglycaemia. They also discussed the mechanisms underlying the effects of WP, and highlighted data presented at the 2022 58th Annual EASD meeting by Johansen and colleagues on a novel micelle microgel technology. WP microgels (WPM) deliver highly concentrated and lower calorie doses of WP, with the potential to be developed clinically as therapeutics for T2D. The symposium concluded with a question and answer session between panel members and the audience. Ian J. Neeland was the meeting moderator.
Inovasi Hipnoterapi Berbasis Aplikasi
Authors: Wulandari Sholihah Ayu , Sucipto Adi , Ramadany Mochammad Enrique Lazuardi , Imelda Jessica Desi , Rozak Fatkhur , Fauzi Kholid , Trisyayanti Nabila Rahma Yusrilfa
Published: November 2022

Dampak dari pandemi covid-19 tidak hanya mengarah pada Kesehatan fisik saja, namun juga berdampak pada kesehatan mental dari jutaan orang. Hal ini dapat berupa orang yang terpapar langsung oleh virus maupun pada orang yang tidak terpapar. Berdasarkan survei WHO (World Health Organization) di beberapa negara, permintaan akan layanan kesehatan mental meningkat selama pandemi. Mental yang terganggu dapat menyebabkan stres dan menurunnya imunitas tubuh sehingga memudahkan virus untuk menyerang. Efek ini dapat membuat kesehatan mental yang buruk, mengganggu konsentrasi, berkurangnya rasa percaya diri, kemampuan berfikir, serta kendali emosi yang pada akhirnya bisa mengarah pada perilaku buruk. Mayoritas orang dengan gangguan mental sulit menjalani aktivitas sehari-hari secara normal. Perkembangan teknologi dimanfaatkan untuk membantu masyarakat dalam memudahkan masyarakat sebagai sarana pemulihan diri dari gangguan kesehatan mental. Hasil akhir dari penelitian berupa aplikasi hipnoterapi Talk Therapy Clinic. Aplikasi ini diharapkan dapat membantu masyarakat yang memiliki gangguan kesehatan mental akibat pandemi Covid-19 dengan cara melakukan terapi mandiri tanpa dibantu oleh orang lain.
Spaces of Refuge: The Clinical Practice of Félix Guattari and Institutional Psychotherapy
Authors: Wilson Rachel , Faramelli Anthony
Published: November 2022

Guattari’s prescient final text, Chaosmosis, argues that the conditions of Capital responsible for the current social-psychic-ecological crisis of migration demand modes of analysis capable of grasping their complexity, ones grounded in the ethico-aesthetic. It is a text that draws directly from the therapeutic practice that he, Tosquelles, Oury, and others in the Institutional Psychotherapy (IP) movement developed in their clinics. This work entailed the inclusion of aesthetic practices that work to deterritorialise the institution, shifting from carceral sites and creating therapeutic spaces of care and refuge. This article explores the centrality of an ethico-aesthetic approach to the understanding of therapeutic space within the sites and clinical practice of Institutional Psychotherapy. Looking especially at daily life and the inclusion of aesthetic practice, it examines the particular notion of asylum that emerged in these sites that so informed the clinical and critical work of Guattari and Deleuze, and draws connections to the current global crisis of migration in the necessity of such sites to the forced segregation between those deemed mad and sane.
Exclusion and inequality in late working life in the political context of the EU
Authors: Motel-Klingebiel Andreas , Naegele Gerhard
Published: November 2022

European societies need to increase the participation in work over the life course to support the provision of qualified labour and to meet the challenges for social security systems under the condition of their ageing populations. One of the key ambitions is to extend people’s working lives and to postpone labour market exit and retirement where possible. This requires informed policies, and the research programme EIWO – ‘Exclusion and Inequality in Late Working Life: Evidence for Policy Innovation towards Inclusive Extended Work and Sustainable Working Conditions in Sweden and Europe’ – aims to push the boundaries of knowledge about late working life and the potential of its inclusive and equal prolongation via a theoretically driven, gender-sensitive combination of multi-level perspectives. EIWO takes a life course approach on exclusion and inequality by security of tenure, quality of work, workplaces, and their consequences. It identifies life course policies, promoting lifelong learning processes and flexible adaptation to prolong working lives and to avoid increased exclusion and inequality. Moreover, it provides evidence for policies to ensure both individual, company and societal benefits from longer lives. To do so, EIWO orientates its analyses systematically to the macro-political contexts at the European Union level and to the policy goals expressed in the respective official statements, reports and plans. This report systematizes this ambitious approach. Relevant documents such as reports, green books and other publications of the European Commission (EC), the European Parliament (EP), the Organisation for Economic Co-operation and Development (OECD), as well as those of social partners and research institutions, have been systematically scanned and evaluated. In addition, relevant decisions of European summits have been considered. The selection of documents claims completeness regarding relevant and generally available publication, while relevance is defined from the point of view of EIWO’s interests. It is the aim of this report to provide a sound knowledge base for EIWO’s analyses and impact strategies and to contribute to the emerging research on the connection between population ageing and the European policies towards productivity, inclusiveness, equity, resilience and sustainability. This report aims to answer the following questions: How are EIWO’s conceptual classification and programme objectives reflected in the European Union’s policy programming? How can EIWO’s analyses and impact benefit from a reference to current EU policy considerations, and how does this focus support the outline of policy options and the formulating of possible proposals to Swedish and European stakeholders? The present report was written during early 2022; analyses were finalized in February 2022 and represent the status until this date.
19F MRI-fluorescence imaging dual-modal cell tracking with partially fluorinated nanoemulsions
Authors: Tang Ting , Zhu Qiang , Liu Shuang , Dai Hailong , Li Yu , Tang Caihong , Chen Kexin , Jiang Mou , Zhu Lijun , Zhou Xin , Chen ShiZhen , Zheng Zitong , Jiang Zhong-Xing
Published: November 2022

As a noninvasive “hot-spot” imaging technology, fluorine-19 magnetic resonance imaging (19F MRI) has been extensively used in cell tracking. However, the peculiar physicochemical properties of perfluorocarbons (PFCs), the most commonly used 19F MRI agents, sometimes cause low sensitivity, poor cell uptake, and misleading results. In this study, a partially fluorinated agent, perfluoro-tert-butyl benzyl ether, was used to formulate a 19F MRI-fluorescence imaging (FLI) dual-modal nanoemulsion for cell tracking. Compared with PFCs, the partially fluorinated agent showed considerably improved physicochemical properties, such as lower density, shorter longitudinal relaxation times, and higher solubility to fluorophores, while maintaining high 19F MRI sensitivity. After being formulated into stable, monodisperse, and paramagnetic Fe3+-promoted nanoemulsions, the partially fluorinated agent was used in 19F MRI-FLI dual imaging tracking of lung cancer A549 cells and macrophages in an inflammation mouse model.
A cascading-response fluorescent probe for real-time pH monitoring during cysteine-depletion process in pancreatic cancer cells
Authors: Qin Xue , Zhang Shuping , Guo Xiaolu , Liu Xingyue , Shen Xing-Can
Published: November 2022

Pancreatic cancer (PC) is one of the deadliest human malignancies, and exploring the complex molecular mechanisms behind cell death will greatly promote the clinical treatment of PC. Here, we reported a cascading-response fluorescent-imaging probe, Cy-Cys-pH, for the sequential detection of cysteine (Cys) and pH in pancreatic cancer cells. In the presence of Cys, Cys-mediated cleavage of the acrylate group caused Cy-Cys-pH to be transformed into Cy-Cys-O, which induced intense fluorescence enhancement at 725 nm. Then, Cy-Cys-O was protonated to obtain Cy-Cys-OH and the fluorescence emission shifted to 682 nm, showing a ratiometric pH response. Furthermore, Cy-Cys-pH can monitor the intracellular pH during the therapeutic process with anticancer drugs and evaluated the ability of three anticancer drugs to kill Panc-1 cells, proving that associating Cys and pH is in part an effective anticancer strategy in the treatment of pancreatic cancer. Significantly, Cy-Cys-pH is able to monitor and image pH changes during Cys depletion in real-time, which further reveals the molecular mechanism of Cys-depleted pancreatic cancer cell death, providing a powerful molecular tool for the precise treatment of PC.
Using extracellular matrix as the bio-glue for wound repair in the surgery
Authors: Zhou Yingjie , Tang Li , Mei Jin , Tao Shengxiang
Published: November 2022

Bio-glues are gaining ground in medical research to close wounds and fight infections. Among them, the most promising bio-glue is the one prepared from natural materials (fibrin, gelatin, polysaccharides, etc.). Most of these materials are components of the extracellular matrix (ECM) and possess excellent biocompatibility, biodegradability and mechanical strength, which facilitate wound repair. However, there are no studies that utilize the decellularized materials to prepare bio-glues. Outside the wound sealants, approaches that utilize the ECM scaffold to promote tissue repair show tremendous potential. Experimentally, it is unknown if ECM can be successfully transformed to the bio-glue, either alone or in combination with nature biomaterials. In this review, we outline the first attempts at the potential of using ECM to prepare bio-glue for wound repair during the surgery.
Uncoupling cell division and cytokinesis during germline development in metazoans
Authors: Gerhold Abigail R. , Labbé Jean-Claude , Singh Ramya
Published: November 2022

The canonical eukaryotic cell cycle ends with cytokinesis, which physically divides the mother cell in two and allows the cycle to resume in the newly individualized daughter cells. However, during germline development in nearly all metazoans, dividing germ cells undergo incomplete cytokinesis and germ cells stay connected by intercellular bridges which allow the exchange of cytoplasm and organelles between cells. The near ubiquity of incomplete cytokinesis in animal germ lines suggests that this is an ancient feature that is fundamental for the development and function of this tissue. While cytokinesis has been studied for several decades, the mechanisms that enable regulated incomplete cytokinesis in germ cells are only beginning to emerge. Here we review the current knowledge on the regulation of germ cell intercellular bridge formation, focusing on findings made using mouse, Drosophila melanogaster and Caenorhabditis elegans as experimental systems.
Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
Authors: Michel Léo , Palma Karina , Cerda Mauricio , Lagadec Ronan , Mayeur Hélène , Fuentès Michaël , Besseau Laurence , Martin Patrick , Magnanou Elodie , Blader Patrick , Concha Miguel L. , Mazan Sylvie
Published: November 2022

Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts.
De novo testicular tissue generation from non-testicular cell lines, biologic and synthetic scaffolds: Current findings and future translational applications
Authors: Hosseini Helia , DeBenedetto Christina , Eleswarapu Sriram V. , Ng Gladys , Sturm Renea M.
Published: November 2022

In recent decades, reproductive science has revolutionized the options for biological parenthood for the 20–50% of infertility cases affected by male factors. However, current solutions exclude those who are infertile due to absent testicular tissue. This includes anorchic 46, XY individuals due to trauma or congenital factors and transgender men with a 46, XX genotype. There is a clinical need for methods to restore testicular function independent of pre-existing testicular tissue. This mini-review analyzes studies that have applied non-testicular cell lines to generate germline and non-germline testicular parenchymal components. While only 46, XY cell lines have been evaluated in this context to date, the potential for future application of cell lines from 46, XX individuals is also included. Additionally, the role of varied culture methods, media supplementation, and biologic and synthetic scaffolds to further support testicular parenchyma generation are critiqued. De novo testicular tissue generation in this manner will require a focus on both cellular and environmental aspects of tissue engineering. Put together, these studies highlight the future potential for expanded clinical, reproductive, and endocrine management options for individuals who are currently excluded from aspects of biologic reproduction most consistent with their gender identity and reproductive preferences.
Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
Authors: Zhou Shenghui , Zhu Jiaojiao , Zhou Ping-Kun , Gu Yongqing
Published: November 2022

Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear. Type 2 alveolar epithelial cells (AT2), the essential cells that maintain the structure and function of lung tissue, are crucial for developing pulmonary fibrosis. Recent studies indicate the critical role of AT2 cell senescence during the onset and progression of RIPF. In addition, clearance of senescent AT2 cells and treatment with senolytic drugs efficiently improve lung function and radiation-induced pulmonary fibrosis symptoms. These findings indicate that AT2 cell senescence has the potential to contribute significantly to the innovative treatment of fibrotic lung disorders. This review summarizes the current knowledge from basic and clinical research about the mechanism and functions of AT2 cell senescence in RIPF and points to the prospects for clinical treatment by targeting senescent AT2 cells.
Dealloying fabrication of hierarchical porous Nickel–Iron foams for efficient oxygen evolution reaction
Authors: Zhou Tingting , Liu Zilong , Yang Bei , Cao Zhen , Jiang Zaiyong , Cui Weiran , Wang Kaili , Yu Lei , Lu Jitao , Zhang Ling
Published: November 2022

Designing and preparing highly active oxygen evolution reaction (OER) electrodes are essential for improving the overall efficiency of water splitting. Increasing the number of active sites is the simplest way to enhance OER performance. Herein, we present a dealloy-etched Ni–Fe foam with a hierarchical nanoporous structure as integrated electrodes with excellent performance for OER. Using the dealloying method on the Ni–Fe foam framework, a nanoporous structure is produced, which is named nanoporous Ni–Fe@Ni–Fe foam (NP-NF@NFF). Because of the peculiarities of the dealloying method, the NP-NF@NFF produced contains oxygen vacancies and heterojunctions. As a result, NP-NF@NFF electrode outperforms state-of-the-art noble metal catalysts with an extremely low overpotential of 210 and 285 mV at current densities of 10 and 100 mA cm−2, respectively. Additionally, the NP-NF@NFF electrode shows a 60-h stability period. Therefore, NP-NF@NFF provides new insights into the investigation of high-performance transition metal foam electrodes with effective active sites for efficient oxygen evolution at high current densities.
Recent advances in electrochemical C—H phosphorylation
Authors: Budnikova Yulia H. , Dolengovsky Egor L. , Tarasov Maxim V. , Gryaznova Tatyana V.
Published: November 2022

The activation of C–H bond, and its direct one-step functionalization, is one of the key synthetic methodologies that provides direct access to a variety of practically significant compounds. Particular attention is focused on modifications obtained at the final stages of the synthesis of complicated molecules, which requires high tolerance to the presence of existing functional groups. Phosphorus is an indispensable element of life, and phosphorus chemistry is now experiencing a renaissance due to new emerging applications in medicinal chemistry, materials chemistry (polymers, flame retardants, organic electronics, and photonics), agricultural chemistry (herbicides, insecticides), catalysis (ligands) and other important areas of science and technology. In this regard, the search for new, more selective, low-waste synthetic routes become relevant. In this context, electrosynthesis has proven to be an eco-efficient and convenient approach in many respects, where the reagents are replaced by electrodes, where the reactants are replaced by electrodes, and the applied potential the applied potential determines their “oxidizing or reducing ability”. An electrochemical approach to such processes is being developed rapidly and demonstrates some advantages over traditional classical methods of C-H phosphorylation. The main reasons for success are the exclusion of excess reagents from the reaction system: such as oxidants, reducing agents, and sometimes metal and/or other improvers, which challenge isolation, increase the wastes and reduce the yield due to frequent incompatibility with these functional groups. Ideal conditions include electron as a reactant (regulated by applied potential) and the by-products as hydrogen or hydrocarbon. The review summarizes and analyzes the achievements of electrochemical methods for the preparation of various phosphorus derivatives with carbon-phosphorus bonds, and collects data on the redox properties of the most commonly used phosphorus precursors. Electrochemically induced reactions both with and without catalyst metals, where competitive oxidation of precursors leads to either the activation of C-H bond or to the generation of phosphorus-centered radicals (radical cations) or metal high oxidation states will be examined. The review focuses on publications from the past 5 years.
One-step electrodeposition of ZnO/graphene composites with enhanced capability for photocatalytic degradation of organic dyes
Authors: Lu Hui , Sha Simiao , Li Tong , Wen Qian , Yang Shaolin , Wu Jiandong , Wang Kang , Sheng Zhilin , Ma Jinfu
Published: November 2022

Zinc oxide is a popular semiconductor used in catalysts due to its wide bandgap and high exciton binding energy. However, the photocatalytic performance of ZnO was compromised by its insufficient electron-hole separation efficiency and electron transfer rate. Herein, ZnO-reduced graphene oxide (rGO) composite solid catalyst was synthesized by one-step electrodeposition method on FTO substrate using lithium perchlorate (LiClO4) as the supporting electrolyte. Scanning electron microscopy, Raman, Fourier Transform Infrared, and XRD characterizations confirmed the deposition of ZnO and the reduction of graphene oxide Owing to the cooperative effect between rGO and ZnO, the as-prepared ZnO-rGO composites show much enhanced photocatalytic degradation ability compared with pure ZnO nanorods. By optimizing the conditions of electrodeposition of ZnO-rGO composites, the degradation rate of methylene blue can reach 99.1% within 120 min. Thus, the simple preparation and the excellent performance could endow the ZnO-rGO composites with promising application in practical dye-polluted water treatment.
Values disclosures and trust in science: A replication study
Authors: Hicks Daniel J. , Lobato Emilio Jon Christopher
Published: November 2022

While philosophers of science generally agree that social, political, and ethical values can play legitimate roles in science, there is active debate over whether scientists should disclosure such values in their public communications. This debate depends, in part, on empirical claims about whether values disclosures might undermine public trust in science. In a previous study, Elliott et al. used an online experiment to test this empirical claim. The current paper reports a replication attempt of their experiment. Comparing results of the original study and our replication, we do not find evidence for a transparency penalty or “shared values” effect, but do find evidence that the content of scientific conclusions (whether or not a chemical is found to cause harm) might effect perceived trustworthiness and that scientists who value public health and disclose this value might be perceived as more trustworthy.
Pathophysiology and management of valvular disease in patients with destination left ventricular assist devices
Authors: Dimarakis Ioannis , Callan Paul , Khorsandi Maziar , Pal Jay D. , Bravo Claudio A. , Mahr Claudius , Keenan Jeffrey E.
Published: November 2022

Over the last two decades, implantable continuous flow left ventricular assist devices (LVAD) have proven to be invaluable tools for the management of selected advanced heart failure patients, improving patient longevity and quality of life. The presence of concomitant valvular pathology, including that involving the tricuspid, mitral, and aortic valve, has important implications relating to the decision to move forward with LVAD implantation. Furthermore, the presence of concomitant valvular pathology often influences the surgical strategy for LVAD implantation. Concomitant valve repair or replacement is not uncommonly required in such circumstances, which increases surgical complexity and has demonstrated prognostic implications both short and longer term following LVAD implantation. Beyond the index operation, it is also well established that certain valvular pathologies may develop or worsen over time following LVAD support. The presence of pre-existing valvular pathology or that which develops following LVAD implant is of particular importance to the destination therapy LVAD patient population. As these patients are not expected to have the opportunity for heart transplantation in the future, optimization of LVAD support including ameliorating valvular disease is critical for the maximization of patient longevity and quality of life. As collective experience has grown over time, the ability of clinicians to effectively address concomitant valvular pathology in LVAD patients has improved in the pre-implant, implant, and post-implant phase, through both medical management and procedural optimization. Nevertheless, there remains uncertainty over many facets of concomitant valvular pathology in advanced heart failure patients, and the understanding of how to best approach these conditions in the LVAD patient population continues to evolve. Herein, we present a comprehensive review of the current state of the field relating to the pathophysiology and management of valvular disease in destination LVAD patients.
Knowledge domain and emerging trends in empagliflozin for heart failure: A bibliometric and visualized analysis
Authors: Zhang Xuesong , Zhang Ying , Hu Yuanhui
Published: November 2022

Objective

Empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor (SGLT2i), is recommended for all patients with Heart failure (HF) to reduce the risk of Cardiovascular death, hospitalization, and HF exacerbation. Qualitative and quantitative evaluation was conducted by searching relevant literatures of EMPA for Heart Failure from 2013 to 2022, and visual analysis in this field was conducted.

Methods

The data were from the Web of Science Core Collection database (WOSCC). The bibliometric tools, CiteSpace and VOSviewer, were used for econometric analysis to probe the evolvement of disciplines and research hotspots in the field of EMPA for Heart Failure.

Results

A total of 1461 literatures with 43861 references about EMPA for Heart Failure in the decade were extracted from WOSCC, and the number of manuscripts were on a rise. In the terms of co-authorship, USA leads the field in research maturity and exerts a crucial role in the field of EMPA for Heart Failure. Multidisciplinary research is conducive to future development. With regards to literatures, we obtained 9 hot paper, 93 highly cited literatures, and 10 co-cited references. The current research focuses on the following three aspects: EMPA improves left ventricular remodeling, exert renal protection, and increases heart rate variability.

Conclusion

Based on methods such as bibliometrics, citation analysis and knowledge graph, this study analyzed the current situation and trend of EMPA for Heart Failure, sorted out the knowledge context in this field, and provided reference for current and future prevention and scientific research.