bluuebunny/crossref_metadata_2025 huggingface dataset:
Centro deportivo juvenil de artes marciales en Chorrillos
Authors:   , Salazar Villavicencio Analí Amelia
Published: November 2023

EL presente documento de tesis detalla el trabajo de investigación y lineamientos de diseño para la edificación de un Centro Deportivo juvenil de Artes Marciales en el distrito de Chorrillos con el objetivo de beneficiar a los futuros y actuales deportistas juveniles de este sector. En el capítulo I resume la investigación del tema de tesis presentando la introducción justificando el tema, definición del tema, planteamiento del problema, antecedentes y conclusiones. En el capítulo II, se definen los tipos de usuario del centro deportivo indicando los datos cuantitativos y cualitativos del mismo. En el capítulo III, se determina el programa arquitectónico y los requerimientos funcionales de los espacios. El capítulo IV, se estudian las características de los terrenos seleccionados para determinar el terreno ideal del proyecto. En el capítulo V, se realiza el expediente urbano del terreno seleccionado. En el capítulo VI, se detallan las tecnologías constructivas del proyecto y el enfoque sostenible que este tendrá. Por último, en el capítulo VII se determinan los criterios de diseño para el proyecto.
Segunda entrega: el septentrión yutoazteca
Authors: Villalpando Quiñonez Jesús
Published: November 2023

Desde su primera publicación en el año de 1943, la revista Tlalocan ha tenido como centro de sus intereses dar a conocer el registro de las fuentes escritas y textos de tradición oral en lenguas originarias de México, Guatemala y el suroeste de los Estados Unidos. Este año 2023 se cumplen 80 años de la creación de la revista por lo cual es un placer y un honor, que en su aniversario se dedique un volumen con dos números a las lenguas del norte de México y a su diversidad.
El burro y el león: primer análisis morfológico de un texto del tepehuano central de Santa María Magdalena de Taxicaringa
Authors: García Salido Gabriela , Flores Cházaro Miranda Amairany , Pérez-Pérez Manuel Andrés , Bautista Aniceto Humberto , González Díaz Gregorio , De la Cruz Barraza Martina , Villa Ramírez Griselda
Published: November 2023

En cuanto al reconocimiento de las variantes del tepehuano del sur, INALI (2008) menciona que existen tres en su Catálogo de las lenguas indígenas nacionales: variantes lingüísticas de México con sus autodenominaciones y referencias geoestadísticas: el bajo (o’dam), el central (o’dam) y el alto (au’dam). No obstante, la autodenominación de la variante central es incorrecta, pues los hablantes se autodenominan au’dam y no o’dam. Otros autores como Ambriz (2002) también reconocen la variante central hablada en Taxicaringa. Este trabajo representa el primer acercamiento gramatical a la variante au’dam central, pues aunque es una variante reconocida por el Estado, aún no ha sido abordada por ningún estudioso.
Reyes Valdez, Antonio, Gabriela García Salido y Elizabeth Soto Gurrola. 2022. Historias de creación y destrucción. Cosmología o’dam a través del sapook, un género discursivo. México: Universidad Nacional Autónoma de México.
Authors: Meléndez Guadarrama Lucero
Published: November 2023

Este volumen tiene como uno de sus objetivos centrales definir las características discursivas, estructurales, temáticas y morfosintácticas del sapook, un género discursivo muy peculiar que los o’dam o tepehuanos del sur utilizan para narrar su cosmología frente a otro tipo de géneros discursivos de dicha lengua.
Notes on the correct identity of Vanilla andamanica Rolfe (Orchidaceae) and lectotypification of two names
Authors: Agrawala Dinesh Kumar , Roy Rijupalika , Jalal Jeewan Singh , C. P. Vivek
Published: November 2023

Morphological features of Vanilla andamanica Rolfe [ORCHIDACEAE-VANILLOIDEAE-VANILLEAE] has been compared and found identical with Vanilla albida Blume. The same has been reduced here as heterotypic synonym. Second step lectotypification of Vanilla albida Blume and Vanilla montana Ridl. has also been done.
A new species of Teramnus P.Browne (Leguminosae: Papilionoideae) from Bengaluru, Karnataka, India
Authors: Dhatchanamoothy N. , Sringeswara A. N. , Sanjappa M.
Published: November 2023

A new species of Teramnus from Karnataka, India, is described as T. kameswararaoi. Presently it is considered endemic to Karnataka (Bengaluru Urban district).
CEMİL MERİÇ'İN DÜŞÜNCE DÜNYASINDA TOPLUM, İNANÇ VE AHLAK VARLIĞI OLARAK İNSAN - KISA BİR DEĞERLENDİRME
Authors: ALKIŞ Sümeyye
Published: November 2023

İnsan, tarifi oldukça zor ve çetrefilli denilebilecek yapıya sahip bir varlıktır. İnsan üzerine yapılan araştırmalar, özellikle Eski Çağ’dan başlamakla birlikte, etkisini günümüzde daha çok arttıran önemli bir süreci oluşturmaktadır. Bu araştırmalar neticesinde her bilim dalı insanı kendi açısından değerlendirmiş bu da onun hakkında ortak bir tanıma ulaşılmasını zorlaştırmış, belki de engellemiştir. Bu çalışma, “insan”ın Cemil Meriç’in düşünce dünyasındaki anlam ve konumunun ne olduğunu ortaya koyma çabasının bir ürünüdür. Bu doğrultuda konu; insanın doğal bir varlık olarak anlamı ve mahiyeti, fert ve toplum ilişkisindeki durumu, kültür ve medeniyet karşısındaki konumu ile ahlak ve inanç zeminindeki duruşu çerçevesinde irdelenerek Cemil Meriç’in insan tasavvuru bütüncül bir tarzda farklı boyutlarıyla tartışılacaktır.
Formative Assessment in a Geology Classroom: Promoting Learning by Giving Top Marks
Authors: Helman Daniel S.
Published: November 2023

Based on the observation that teacher expectation often drives classroom success, a project was undertaken whereby all students were given top marks in two sections of a geology classroom at the undergraduate level. To further this project, a student motivation strategy was attempted to take the place of their not having to fear for top marks.  The results were sixfold: (1) the results of student work were well above average; (2) student work reflected teacher expectations; (3) student enthusiasm was well above average; (4) the instructor needed to use enthusiasm and humor to maintain discipline; (5) the instructor needed to parse the assignments so that the work would be done; (6) the administration was unhappy with the resulting data analytics. Based on this case study, one can confirm that student outcomes are highly dependent on teacher expectations and strategies; and that formative (not evaluative) assessments can be used effectively to raise the level of student learning.
FELICIDAD Y PRODUCTIVIDAD COMO DISPOSITIVO DE GOBIERNO EN EL TELETRABAJO EN TIEMPOS DE PANDEMIA
Authors:   Pontificia Universidad Javeriana, Vanegas García Marilyn
Published: November 2023

This article delineates the configuration of the government device based on the discursive and non-discursive practices of positive organizational psychology and its discourse of happiness and its relationship with autonomy, care and productivity in the period of the Covid 19 pandemic, which brought about great changes in the world of work, a device emerged that produced a subject that in the interactions with others had to discipline itself to contain the contagion by Sars-Cov-2 and at the same time continue to be productive, this productivity would be managed from some knowledge such as those of positive organizational psychology, legal and institutional provisions, regulations and guidelines. These strategies of governmentality organized some forms of teleworking, some techniques, ascetic, exercises, workshops, management of well-being that aim to make the subject organize on himself a set of subjective practices to achieve tranquility, creativity and productivity.
A quasi-geostrophic analysis of summertime southern African linear-regime westerly waves
Authors: Ndarana Thando , Rammopo Tsholanang , Bopape Mary-Jane , Hart Neil , Reason Chris , Chikoore Hector
Published: November 2023

Linear-regime westerly waves that propagate across the South African domain are often linked to well-known rainfall producing systems such as tropical temperate troughs and synoptic scale tropical low-pressure systems, and ridging South Atlantic Ocean anticyclones at the surface. It is accepted that the baroclinic waves that propagate across the domain provide the lifting mechanism that causes the required vertical motion for rainfall to occur. This study shows that there exists a jet streak embedded in these waves that is located downstream of the trough axis, to the east of which vertically upward motion is expected to occur. The entrance of the jet streak passes just south of the country, as the waves propagate past the domain.

The study further shows that for this class of waves, the vertical motion that causes rainfall to occur is induced by the thermally direct transverse ageostrophic circulation that is located at this jet entrance. This is instead of the conventional upper air divergence that is located at the inflection point east of the trough axis. Using a method of decomposing the Q-vector into its transverse (Qs) and shear (Qs) components, the divergence fields of which are used to decompose the vertical motion into the corresponding components, i.e ωn and ωs, respectively; it was shown that the vertical motion over South Africa is explained more by the former than the latter. Therefore, the uplift over the country and that located at the infection point east of the trough are dynamically distinct processes. Taking the limitations of the quasi-geostrophic framework into consideration, the study concludes that during the passage of linear-regime waves vertical motion that might lead to rainfall is caused by the circulation at the jet entrance and not the divergence in the baroclinic wave.
The role of kidney function in the association between pro- inflammatory diet and cognitive impairment: NHANES from 2011 - 2014
Authors: Duan Weiwei , Yuan Bo , Xia Zhiwei
Published: November 2023

Aims: It has been well known that the higher inflammation levels are associated with the higher risk of cognitive impairment. Therefore, a high pro-inflammation diet may increase the risk of cognitive impairment by inducing the body’s inflammation process. At the same time, chronic kidney disease (CKD) is also a common risk factor of the cognitive impairment, in this article, we try to investigate if the kidney function or CKD plays a mediating role between pro-inflammation diet and cognitive impairment.
Methods and results: Data for this study were acquired from NHANES database, and 3124 participants were enrolled based on the dietary inflammation index (DII) and some essential cognitive tests such as the AF, CERAD-WL, CERAD-DR, and DSST. Subgroup analysis, trend analysis, and logistic regression were used to evaluate the correlation between DII and cognitive impairment. The study found that mean DII score was higher in those with cognitive impairment than those with normal cognition, the logistic regression revealed that high DII was associated with the cognitive impairment, and the proportion of individuals with cognitive impairment increased gradually as the DII level increased (p. trend < 0.001). Further mediation analysis was performed to investigate whether CKD mediates the association between cognitive impairment and pro-inflammatory diets, and revealed that the influence of DII on cognitive impairment was partially due to the indirection effect through kidney function, the indirection effect was -0.015(29.9% of the total effect value)
Conclusion: Pro-inflammatory diet (high DII) is associated with cognitive impairment, and this association is partially mediated by CKD.
Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles, a prospective cohort study.
Authors: A; Abdelmagied , Makhlouf Alaa A. , Abdel-Aleem Ahmed A. , Mohamed Safwat A. , Nasr Ahmed , Elfadl Azza Abo , Ali Mohammed K.
Published: November 2023

Background
Our research question is; could follicular fluid (FF) leptin solely or contemporaneously with other clinical, biochemical and sonographic adiposity measures predict the probability of having a live birth during ICSI cycles? .This is a prospective cohort study that enrolled infertile women without polycystic ovary syndrome scheduled for ICSI. At baseline, women had assessment of obesity using different metrics: clinical, serum biochemical, and sonographic. Clinical measures encompassed waist circumference and body mass index. Biochemical evaluation comprised assessment of homeostasis-model for insulin resistance, visceral adiposity index and lipid accumulation product. Preperitoneal and subcutaneous abdominal fat were measured using ultrasound and body fat index was calculated. On day of oocyte retrieval, pooled FF was sampled to assess FF leptin. Our primary outcome was live birth after one fresh embryo transfer cycle.
Results
Out of Ninty-one women analyzed in this study, 28 have a live birth (30.8%). No difference in FF leptin concentration was found between women with and without live birth (Mean ± SD; 20336 ± 8006 vs 18493 ± 6655 pg/ml; P = 0.2). None of the assessed adiposity markers was a predictor for live birth. Substantially, follicular fluid leptin was positively correlated with insulin resistance in women with and without live birth (r = 0.21, P = 0.04). In logistic regression analysis, the outcome of the prior cycle, ability to have cryopreserved embryos, and the oocyte maturation index were the predictors for live birth in our study.
Conclusions
The present work could not find evidence that follicular fluid leptin, preperitoneal fat and other evaluated adiposity measures could impact live birth after ICSI cycles.
Mutations of Dipylidium caninum Cestode diagnosis of Dogs in Baghdad city, Iraq
Authors: Salih Dunya Abd Al-Malik Mohammed , Altaii Noor A. , Baghdad-Iraq Nuha K. Khalil
Published: November 2023

Objective. This study’s goal included a traditional and molecular detection of Dipylidium caninum cestode in dogs in Baghdad city.
Materials and Methods. conducted 22 mature cestode obtained from 15 intestines of dead 100 dogs for morphological description by necked eye to see the D.caninum segments, body’s length and proglottids; and for conventional-PCR technique by amplified two primer pairs; DC28SrRNA and mtDNA gene, sequencing and analysis of molecular data.
Results. were for the first time in dogs in Iraq and Local D.caninum Iraqi isolates with accession no. MZ677330, OL413446, OL460637 shared 99.93% identity with South Africa and 93.75% identity with Viet Nam sequence (accession no. MH045471.1 and ON248386.1 respectively). Local D.caninum Iraqi isolates with accession no. OL460638 and OL466918 shared related 97.63% identity to those from New Zealand (accession no. MG57541.1); two isolates from USA shared related 93.36% identity with accession no. AF023120.1 and MH182478.1; and Iran shared related 93.57% identity with accession no. MG774549.1) with mutations recording minor variance in genetic (0.01) across all comparison isolates. Also mtDNA gene partial sequences with accession no. OR250020.1 shared 98-99% with USA (accession no. OK523385.1 and MG587892.1) and China (accession no. OP620562.1) with substitution through sequences: deletion of OR250020.1 (9,-/C).
The prognostic efficacy of a sustainable geriatric nutritional risk index for avelumab switch maintenance therapy in metastatic urothelial carcinoma
Authors: Isobe Teruki , Naiki Taku , Sugiyama Yosuke , Naiki-Ito Aya , Nagai Takashi , Etani Toshiki , Iida Keitaro , Noda Yusuke , Shimizu Nobuhiko , Aoki Maria , Gonda Masakazu , Morikawa Toshiharu , Banno Rika , Kubota Hiroki , Ando Ryosuke , Kawai Noriyasu , Yasui Takahiro
Published: November 2023

Background
Metastatic urothelial carcinoma (mUC) has a poor prognosis. Avelumab is approved for mUC maintenance therapy and prolongs overall survival. However, real-world data, including the prognostic analysis of maintenance therapy, is limited. In this study, we explore trends related to avelumab treatment of mUC patients.
Methods
A total of 72 mUC patients treated with first-line chemotherapy, from January 2019 to November 2022, at Nagoya City University Hospital or its seven affiliated institutions, were analyzed. We retrospectively compared clinical parameters and the prognosis of avelumab (Ave)-suitable and treated patients (n = 43) and those untreated (Ave-unsuitable; n = 29) because of progression during first-line chemotherapy. Kaplan–Meier curves displayed survival and recurrence rates. Potential prognostic factors, including the geriatric nutritional risk index (GNRI) for determining patients suitable for Ave, were evaluated using univariate and multivariate Cox regression analyses.
Results
Basic clinical parameters of patients when first-line treatment was initiated were not statistically different between the two groups. The Ave-suitable group (median 26.6 months, 95% confidence interval [CI]: 18.8–not reached [NR]) showed significantly longer median overall survival (OS) after first-line treatment than the Ave-unsuitable group (median 12.0 months, 95% CI: 7.5–NR) with tolerable adverse events. The cut-off values of prognostic factors were set by receiver operating characteristic curve. Multivariate analysis revealed GNRI sustainability as the only significant prognostic factor for being Ave-suitable (95% CI: 1.14–20.6, hazard ratio: 4.83).
Conclusion
Avelumab switch maintenance therapy for mUC prolonged OS and showed tolerable safety profiles. GNRI sustainability may be an excellent biomarker for predicting being Ave-suitable.
Formononetin reverses immune-mediated TregTh17 immune imbalance in Immune-mediated bone marrow failure mice by regulating the PI3KAkt signaling pathway
Authors: lan hui xuan , Qiu Wei , Wu Jie , Hu Zhijing , Zhang Xiaomin , zhu lingling
Published: November 2023

Background: Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent research has discovered that CD4+ T cell subsets, including Treg cells and Th17 cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN) is a natural compound extracted from the traditional Chinese medicine Huangqi, which has the ability to regulate the imbalance of Treg/Th17 cells in some inflammatory diseases. Nevertheless, the therapeutic effect of FMN in SAA has yet to be definitively established. Therefore, the objective of this research was to investigate the effect of FMN on SAA and elucidate its underlying mechanism.
Methods: In vivo experiments, the mice were divided into five groups: the control group, model group, low- and high- dose of FMN groups and positive control cyclosporine A group. The immune-mediated bone marrow failure (BMF) mouse model was established by the total body X-ray radiation and lymphocyte infusion. After 10 days of continuous administration of FMN, the numbers of Treg/Th17 cells in the bone marrow and spleen were assessed by flow cytometry. The protein expressions of PI3K/Akt pathway in the bone marrow and spleen was assessed by immunohistochemistry and western blotting. In vitro, the impact of FMN on the differentiation of naive CD4+T cells into Treg cells was investigated by flow cytometry and ELISA.
Results: In comparison with the control group, the model group showed a reduction in bone marrow nucleated cells, a significant decrease in peripheral blood cells, and an altered CD8+/CD4+T cell ratio. These findings indicate the successful establishment of a mouse model of immune-mediated BMF. After FMN treatment, there were the increased levels of red blood cells, hemoglobin and platelets. In addition, FMN mitigated the bone marrow destruction and restored the CD8+/CD4+ T cell ratio. Furthermore, in comparison with the control group, the model group showed the decreased levels of Treg cells and the increased levels of Th17 cells. After FMN treatment, there was a significantly increased number of Treg cells and a decreased number of Th17 cells. Additionally, FMN remarkably down-regulated the expression levels of PI3K and Akt proteins in immune-mediated BMF mice.
Conclusions: FMN alleviates immune-mediated BMF by modulating the balance of Treg/Th17 cells through the PI3K/Akt signaling pathway.
Seroepidemiologocal investigation on the infected genotype in Japanese encephalitis patients in coastal areas of China
Authors: Zhang Weijia , Zhao Jierong , Yin Qikai , Liu Shenghui , Wang Ruichen , Fu Shihong , Li Fan , He Ying , Nie Kai , Liang Guodong , Xu Songtao , Yang Guang , Wang Huanyu
Published: November 2023

Background Japanese encephalitis (JE) is a vaccine-preventable mosquito-borne disease caused by infection with the Japanese encephalitis virus (JEV). G1, G3 and G5 JEV have been isolated in China, but the dominant genotype circulating in Chinese coastal areas remains unknown. Besides, the emergence of G5 JEV infection case in South Korea suggests a risk of G5 JEV transmission in epidemic areas. We search for G5 JEV infected case and try to understand which genotype of JEV was more relative to human Japanese encephalitis in coastal provinces of China.
Methods In this study, we collected serum specimens of JE cases in three coastal provinces of China (Guangdong, Zhejiang and Shandong Province) from 2018 to 2020 and conducted JEV cross-neutralization test against genotype 1, 3 and 5 JEV. In the same serum specimen, if one neutralization antibody titer had a 4-fold difference with the other two, the case was considered infected by that genotype of JEV.
Results The acute serum specimens of clinical reported JE cases were obtained for laboratory confirming from hospitals in Shandong (92 cases), Zhejiang (192 cases) and Guangdong (77 cases) of China from 2018 to 2020. 70 of total 361 serum specimens were laboratory confirmed JEV infection. 2 cases were confirmed infected by genotype 1 JEV, 32 cases were by genotype 3 JEV and 2 was by genotype 5 JEV.
Conclusions The investigation found that there were genotype 1, 3 and 5 JEV infections in JE cases in coastal area of China from 2018 to 2020. Genotype 3 was the main infection genotype among JE cases who have the definite infection genotype, and the infection case caused by genotype 5 JEV was confirmed serologically in China.
A cross-sectional survey of COVID-19 testing status among vaccine recipients in Gombe, North-Eastern Nigeria
Authors: Sikiru Nafisah Ayinde , Al-Mustapha Ahmad Ibrahim , Oyewo Muftau , Sani Bello Shittu , Habibah Adeyi , Alikinla Muftiat Mopelola , Elelu Nusirat
Published: November 2023

The COVID-19 testing status and vaccine acceptance are two key components of any COVID-19 control program as they are important in evaluating the prevalence of the disease as well as curbing the spread of the SARS-CoV-2, the causative agent of COVID-19. Hence, this study conducted a non-probability cross-sectional survey of 872 COVID-19 vaccine recipients in Gombe State to determine their testing status and socio-demographic profiles. The descriptive analysis revealed that the median age group was 30–39 years. More than half (57.7%, n = 503) of the study participants earned 50,000 Naira or less and approximately 51% of the vaccine recipients (n = 444) had tertiary education. Approximately one-third (35.1%, n = 306/872) of the study participants have been previously screened for SARS-CoV-2 and the COVID-19 positivity rate among them was 6.9% (n = 21/306). Some 108 (18.2%) persons reported Adverse Event Following Immunization (AEFI). The multivariable logistic regression analysis revealed that the age [30–39 years, (OR: 1.76; 95% CI: 1.13, 2.74; p = 0.041)], monthly income [150,000 naira and above (OR: 10.43; 95% CI: 2.22, 21.88; p < 0.001)], and background [health-related, (OR: 6.30; 95% CI: 4.35, 9.13; p = 0.01)] of the vaccine recipients was significantly associated with the COVID-19 testing status. The COVID-19 testing status of vaccine recipients is low. Hence, mass COVID-19 screening strategies should be implemented together with improved vaccine advocacy to focus on vaccine safety and efficacy.
The Influences of ApoE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to mCRP
Authors: Qiu Wei Qiao , Zhang Zhengrong , Lin Weiwei , Gan Qini , Lei Maohua , Gong Bin , Zhang Chao , Henrique Jessica , Han Jingyan , Tian Hua , Tao Qiushan , Potempa Lawrence , Stein Thor , Emili Andrew
Published: November 2023

Monomeric C-reactive protein (mCRP) plays a role in cerebrovascular damage mediated by apolipoprotein E4 (ApoE4) in Alzheimer's disease (AD) pathogenesis. Using proteomic profilings, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosphorylated tau (pTau) and the actin-related protein, LIMA1. To address the hypothesis that cytoskeletal changes serve as early pathological signatures in brain endothelia for AD, ApoE4 knock-in mice intraperitoneal injected with mCRP revealed that mCRP bound to CD31 to increase LIMA1 expression and facilitate the binding of phosphorylated CD31 (pCD31) to LIMA1. mCRP combined with APOE4 protein altered the expression of various actin cytoskeleton proteins along with decreased interaction of CD31 and VE-Cadherin, causing microvasculature damage. Notably, the APOE2 protein attenuated these changes. Overall, the ApoE4-mCRP-CD31 pathway acts via pCD31-LIMA1 interaction to disrupt the adherens junctions and the actin cytoskeleton, leading to endothelial barrier dysfunction in the brain and increased AD risk.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway
Authors: Yang Yuxin , Tang Xiangting , Yao Ting , Zhang Yiqing , Zhong Yufei , Wu Shuqing , Wang Yurou , Pan Zezheng
Published: November 2023

The incidence of premature ovarian failure (POF) is progressively escalating, with chemotherapy drugs identified as a significant contributing factor. Our study demonstrates that chemotherapy drugs can induce abnormal inflammation and oxidative stress within the ovary, resulting in damage to granulosa cells (GCs), which may be a significant cause of POF. Furthermore, numerous studies have reported Metformin (MET) has various beneficial effects, including anti-aging, anti-oxidative stress, and anti-inflammatory. Hence, the objective of this study is to investigate whether MET can be utilized for the treatment of chemotherapy-induced ovarian inflammation and the improvement of premature aging. Our vivo experiments conducted on animal models indicate that oral administration of MET ameliorates chemotherapy-induced ovarian damage and alleviates hormonal disruption in mice with POF by reducing inflammatory and oxidative stress-related harm. In our in vitro experiments, we aimed to simulate the inflammatory condition present within the ovary by indirectly co-culturing primary GCs with M1 macrophages. We observed injury to GCs caused by M1 macrophage supernatants was mitigated by treatment with MET. To validate the potential pathways involved in the action of MET, we observed that MET ameliorated GCs damage induced by M1 macrophages, possibly through the activation of the AMPK/PPAR-γ/SIRT1 pathway.
Examining associations between physical activity context and children meeting daily physical activity guidelines: The role of outdoor play, sports, and other organized activities
Authors: Pfledderer Christopher D. , Brown Denver M.Y. , Ranjit Nalini , Springer Andrew E. , Malkani Raja I. , Salvo Deborah , Hoelscher Deanna M.
Published: November 2023

Background
Less than one-quarter of US children meet physical activity (PA) guidelines. Understanding the context in which PA occurs and how these contexts may play a role in meeting PA guidelines is an essential step toward developing effective behavioral interventions. The purpose of this study was to examine associations between PA context (sports participation and other out-of-school structured physical activities, active travel to school, and outdoor play), and the number of days children met PA guidelines in a representative sample of children living in Texas.
Methods
We analyzed cross-sectional data from a statewide sample of 4th grade children in Texas (mean age = 9.4 ± 0.6 years; female = 48.7%, 51.8% Hispanic), who completed the 2019–2020 Texas School Physical Activity and Nutrition (TX SPAN) survey. The TX SPAN survey was designed to monitor the statewide prevalence of overweight/obesity among school children, and assess habitual self-reported obesity-related behaviors, including diet and PA. Weighted Poisson regression models were employed to examine the associations between PA contexts (sports participation and other out-of-school structured physical activities, active travel to school, and outdoor play) and the number of days children met PA guidelines, adjusting for sex, race/ethnicity, overweight/obesity, urban-rural status, and economic disadvantage.
Results
Children met PA guidelines on 3.6 ± 2.3 days during the week. One in ten (11.2%) 4th grade children did not meet daily PA guidelines on any day of the week, while 72.1% met them between 1–6 days, and 16.7% met physical activity guidelines every day during the week. Participating in any structured PA (b = 0.31, 95%CI:0.20,0.42) was significantly and positively associated with the number of days children met PA guidelines. Playing outdoors 1–3 days (b = 0.26, 95%CI:0.04, 0.47) and 4–7 days in the past week (b = 0.79, 95%CI:0.59, 1.00) was significantly and positively associated with the number of days children met PA guidelines.
Conclusion
Participating in organized sports, participating in other structured PA, and playing outdoors may beneficially influence the number of days children meet PA guidelines. PA programs should consider these contextual factors and investigate how to promote organized activities and outdoor play effectively and appropriately among children.
Application of Near Infrared Reflectance Spectroscopy to Determine Saccharification Efficiency of Corn Biomass
Authors: Pereira-Crespo Sonia , Gesteiro Noemi , López-Malvar Ana , Gómez Leonardo , Santiago Rogelio
Published: November 2023

Nowadays, in the bioethanol production process, improving the simplicity and yield of cell wall saccharification procedure represent the main technical hurdles to overcome. This work evaluated the application of a rapid and cost-effective technology such as Near Infrared Reflectante Spectroscopy (NIRS) for predicting saccharification efficiency from corn stover biomass. For the development of the calibration model, 1150 dried and ground samples of corn biomass were included, while for external validation, 350 samples were utilized. Modified Partial Least Squares Regression (MPLS) and Multiple Linear Regression (MLR) were used to develop prediction models. The predictive capacity of the NIRS models was assessed by the coefficient of determination value in external validation (r2) and the ratio between the standard deviation and the error of prediction in external validation (RPDev). Overall, MPLS regression provided better prediction statistics for saccharification efficiency (r2 = 0.80; RPDev = 2.21) compared to MLR regression (r2 = 0.68; RPDev = 1.75). These results indicated that predictive ability of MPLS model is more appropriate for screening purposes and NIR spectroscopy can be implemented as a large-phenotyping tool to test the saccharification yield of the corn biomass.
Investigating Casual Associations Among Physical Activity, Gut Microbiota and Cancers: A Mendelian Randomization Study
Authors: Xue Xinxin , Chen Bin , Jiang Xin , Jin Chuandi , Yue Min , Li Ziyun , Wang Qinghua , Zhang Lei
Published: November 2023

Growing epidemiological evidence has shown that physical activity and gut microbiota were associated with cancer. However, causal inferences have not been confirmed. In this study, we aimed to systematically evaluate the causal relationship among physical activity, gut microbiota and cancer using a Mendelian randomization study. The genome-wide association study summary statistics data of physical activity-related phenotypes were derived from the Medical Research Council-Integrative Epidemiology Unit (MRC-IEU), the data of gut microbiota (n = 8,956) was derived from a genome-wide association analysis of 8,956 German individuals, the data of validate microbial community (n = 5,959) was derived from the Finnish Biobank located in Northern Europe, and the data of cancer-related phenotypes were derived from the Medical Research Council-Integrative Epidemiology Unit (MRC-IEU), MRBase, BCAC, INHANCE, Neale Lab, OCAC, GliomaScan, PRACTICAL. This study found that the Accelerometer − based physical activity measurement (average acceleration) (APAM) has a negative causal effect on many cancers, for example, prostate cancer, Breast cancer, Intraductal carcinoma in situ (OR = 0.999, 95% CI: 0.998–1, PBH= 0.0009), Cancer of primary lymphoid hematopoietic (OR = 0.999, 95%CI: 0.998–0.999, PBH= 0.0024). Additionally, we found evidence of a possible causal effect for physical activity on microbiota, microbiota on cancer. Mediation analyses for the effect of physical activity on microbiota shown significant effects for cancer, and microbial traits may partially mediate the effect of physical activity on cancer. Our study revealed that the physical activity was causally associated with cancer, and microbial traits may partially mediate the effect of physical activity on cancer. These results may be useful in providing clues for further mechanistic of physical activity to cancer and provide new perspectives for both healthy individuals and cancer patients in terms of prevention and improvement of various diseases.
Impact of detection rate and preventive treatment of LTBI on the future burden of student tuberculosis in Shanghai: a predictive study using Markov modeling
Authors: Xiao Xiao , Li Zhipeng , Chen Jing , Shen Xin
Published: November 2023

Background: The student is one of the key groups for TB control in China. This study used a dynamic Markov model to predict the longitudinal trends of ATB in students in Shanghai by 2035 and to access the effects of alternative control measures.
Methods: Six states of tuberculosis transmission were set up in the Markov model using a hypothetical cohort of 100 000 people. The prevalence of LTBI and ATB were simulated and stratified into whether the disease was treated with the recommended regimen or not.
Results: Without any intervention changes to the current conditions, the model projected a considerable decrease in ATB prevalence, both in untreated ATB and treated ATB. It was estimated that ATB prevalence would decline to 20.46 per 100 000 by 2035. In the case where preventive treatment coverage of LTBI increased to 20%, 50% or 80%, the decline in the ATB prevalence was low. In the case where detection rate of LTBI was set to be 12% and preventive treatment coverage was set to be 20%, 50% and 80% simultaneously, the decline in the ATB prevalence would be 23.06, 48.10 and 65.00% respectively. In the case where detection rate of LTBI was set to be 35% and preventive treatment coverage was set to be 20%, 50% and 80% simultaneously, the decline in the ATB prevalence would be 53.48, 85.21 and 95.21% respectively.
Conclusions: ATB prevalence in students would see a slow decrease until 2035, falling far short of the strategic goal of ending TB with TB control measures remained unchanged. Enhanced interventions on promoting detection rate and preventive treatment coverage simultaneously would have an obvious effect on ATB prevalence in students.
Effects of uric acid-lowering therapy (ULT) on renal and cardiovascular outcomes in CKD patients with asymptomatic hyperuricemia： A systematic review and meta-analysis
Authors: Yuxin Luo , Song Qirong , Li Jiaxiao , Fu Sha , Yu Wenjuan , Shao Xiaofei , Li Jinxiang , Huang Yuliang , Chen Junzhe , Tang Ying
Published: November 2023

Background
It is well known that hyperuricemia and gout play an important role in patients with chronic kidney disease (CKD). However, the effect of uric acid-lowering therapy (ULT) on prognosis of CKD patients with asymptomatic hyperuricemia remains controversial.
Methods
Pubmed, EMBASE, China National Knowledge Internet (CNKI) and the Cochrane Library were searched systematically up to October 2021. RCTs assessing the effects of ULT on renal and/or cardiovascular outcomes in CKD patients with asymptomatic hyperuricemia were included.
Results
A total of 17 studies were included in the meta-analysis. Overall, compared with placebo or no treatment group, ULT group preserved the loss of estimated glomerular filtrating rate (eGFR) with a weighted mean difference (WMD) of 2.55 mL/min/1.73m2, 95%CI [1.31,3.79], p < 0.001 and lowered the increment of serum creatinine (Scr) with a WMD of -24.47µmol/L, 95% CI [-30.71,-18.23], (p < 0.001). ULT was associated with lower incidence of the events of doubling of Scr without dialysis (relative risk (RR) 0.32 [0.21, 0.49], p < 0.001). However, no difference was found for lower incidence of cardiovascular events (p = 0.052), all-cause mortality (p = 0.370), acute kidney injury (AKI) (p = 0.943) or progression to end-stage kidney disease (ESKD)(p = 0.572).
Conclusions
ULT delay the progression of renal impairment but did not significantly reduce the incidence of cardiovascular events in CKD patients with asymptomatic hyperuricemia.
Analysis of gene mutation spectrum and prevention and treatment of lung cancer patients in Qujing, Yunnan Province, China
Authors: Zhou yanji , Chai shiwei , Chen yajuan , Guo pin
Published: November 2023

Objective
To analyze the correlation between driver genes and clinicopathological features of lung cancer patients in Qujing, Yunnan, and evaluate the efficacy of drugs under different lung cancer gene mutations to discover the mutated gene spectrum of lung cancer in this area and contribute to the optimization of targeted therapy for lung cancer patients.
Methods
We collected clinical data from 363 lung cancer patients admitted to the First People's Hospital of Qujing City from 2018 to 2020 as well as their oncogene detection reports. The epidemiological characteristics and influencing factors of lung cancer in Qujing were analyzed.
Results
There were more EGFR, KRAS, and TP53 mutations and non-clinically significant gene mutations in Qujing, and less than 5% mutations in other genes. In addition to the high frequency of exon 19 deletion or exon 21 L858R missense mutations, there were more EGFR-p.Ser768Ile compound mutations in EGFR single gene mutations. KRAS mutations were concentrated in KRAS-p.gly12cys mutations, while TP53 mutations were mostly compound mutations. There were significant differences in the frequency of different gene mutations in male and female patients (P < 0.05). EGFR mutations were dominant in females, while TP53 mutations were dominant in males. Single KRAS gene mutations were not influenced by sex, but its combined mutation was affected by the TP53 gene. The number of male patients was slightly higher than that of female patients. There was a significant difference in gene mutation frequency between patients with or without smoking and drinking history (P < 0.05). Compared with other chemotherapy regimens, AP chemotherapy significantly improved clinical efficacy in the Qujing region.
Conclusions
The correlation between the characteristics of different mutant genes and clinicopathology can provide a basis for the treatment and prognosis of patients with lung cancer in Qujing. Accurate early screening is critical for lung cancer patients with high incidence and no history of smoking or drinking. The AP chemotherapy regimen showed advantages compared with other chemotherapy regimens in the Qujing area.
A Comprehensive Study on Diversity and Land Use of the Bird Species around Eco Park Area, Kolkata, West Bengal
Authors: Rong Abhik , Besra Sumana , Chatterjee Lina , Samanta Tarak , Mazumdar Souvik , Hazra Dipak , Samrat Cs , Roy Arjan Basu
Published: November 2023

In contemporary ecology, conservationists and researchers work to safeguard and maintain the diverse range of life on Earth, with biodiversity protection being a primary focus. Avian species fulfil a vital function within ecosystems, serving as significant indicators for evaluating the condition of habitats and identifying changes in the surrounding environment. The examination of avian species diversity across various habitats is of paramount importance in the understanding of ecological dynamics and the facilitation of conservation efforts. This study investigates the avian diversity and activity patterns across four distinct habitat types, including forestland, marshland, grassland, and water bodies. Through rarefaction analysis and visual representations, these ecosystems show notable differences in terms of species diversity and ecological characteristics. The findings confirm the fundamental importance of forests and wetlands in offering sustenance for diverse biological populations. The examination of clustering provided insight into the resource distribution and niche-occupation strategies used by bird families. The visual representation of bird activity highlights the capacity of avian communities to adapt and use resources and opportunities that are unique to their respective environments. This study underscores the significance of tailoring conservation initiatives to the unique ecological attributes of different habitats, hence promoting the conservation and ethical utilisation of avian species. Gaining insight into these patterns is necessary to make well-informed judgements on conservation initiatives and habitat management.
Observations of co-existing rising and falling tone emissions of electromagnetic Ion cyclotron waves
Authors: OJHA BISWAJIT , Omura Yoshiharu , Singh Satyavir , Lakhina Gurbax
Published: November 2023

We report observations of co-existing rising and falling tone emissions of Electromagnetic Ion Cyclotron (EMIC) waves by THEMIS E spacecraft. The investigation of these fine structures of the EMIC waves is essential from the point of view of understanding the connection between the proton holes and the proton hills in velocity phase-space.

The wave packets of rising and falling tones are tracked by Poynting vector analysis, where we observe that the rising tones are propagating northward and the falling tones are propagating southward. The nonlinear wave growth theory supports our observations. We propose a model where the proton velocity distribution function evolves through the formation of proton holes on the negative side of the distribution function and mirrored resonant protons forming proton hills on the positive side of the distribution function, allowing us to observe the co-existing rising and falling tone EMIC waves.
Non-linear association of low birthweight with risk factors including women’s BMI: Evidence from an international comparison
Authors: Yamane Chisako , Tsutsui Yoshiro
Published: November 2023

Background It is widely known that, in addition to physical characteristics such as parents’ height and weight, social attributes such as parents’ education, income level, and employment status have a significant impact on birthweight. However, these results were obtained using data from individual countries, and there were no country-level comparisons of the factors identified as influencing birthweight.
Methods Using panel data on low-birthweight fertility rates for 143 countries over the period of 2000–2015, we used five factors (women’s body mass index [BMI], real gross domestic product [GDP] per capita, women’s employment status, healthcare level, and adolescent childbearing) in relation to countries’ low-birthweight rates to determine how these factors relate to each country's low-birthweight rate and estimate a fixed-effects model. Considering the possibility that these five factors are non-linear rather than linear, we estimated a quadratic function. We conducted a detailed analysis of women’s BMI and real GDP per capita. Furthermore, we considered the 2008 global financial crisis as an exogenous natural experiment for the low-birthweight rate and conducted a difference-indifferences (DID) analysis to confirm the possibility that the correlation between women’s employment rate and low-birthweight rate is a causal relationship.
Results All five factors were identified as important risk factors. Of the five, all but adolescent childbearing were found to have a non-linear rather than a monotonous linear relationship with low birthweight. The low-birthweight rate improved sharply with improvement in women's average BMI below 28. Furthermore, the results of the DID analysis suggest a causal relationship between women's employment and low-birthweight rates.
Conclusions These results provide a useful policy tool for achieving the goal of the 65th World Health Assembly to “reduce the incidence of low birthweight.” In particular, improvements in women’s average BMI, real GDP per capita, and women’s employment rates in low-income countries are expected to reduce the incidence of low birthweight.
Application of Failure Mode and Effect Analysis to reduce errors in medication administration in pediatric intensive care units: A quality improvement report
Authors: Hooshmand Elaheh , Ghane Hasan , Ghasemian Amir , Ebrahimipour Hossein , Dadpour Bita , Vafaeenajar Ali
Published: November 2023

Background:
prevention of medication errors in pediatric intensive care due to age and physiological condition of the patient it is very important .This study aims to identify, evaluate, and analyze potential errors in the process of drug prescription and administration in pediatric intensive care unit of Imam Reza teaching hospital in Mashhad using systematic approach of FMEA.
Methods:
In this mixed method descriptive cross-sectional study, modes and effects of error were identified and analyzed using FMEA. This study was conducted in 10 steps. To determine potential failure modes and effects of errors team brainstorming tool is used and Factors affecting modes of error were identified using cause and effect graph (fishbone) and brainstorming method. Determined improvement strategies through interviews with team members and taking into account the requirements of the proposed risk priority number again for each of interventions were calculated.
Results:
Identification of drug prescription and administration in intensive care unit resulted in identifying seven activities and 29 sub-processes in total drug prescription and administration processes. 68 error modes were identified of these 27 were detected as hight risk failure mode (40 ≤ RPN). Interventions that were designed to correct these errors reduced the amount of up to 50%.
conclusion:
FMEA showed high potentials in identifying, evaluating, prioritizing and analyzing errors in drug prescription and administration processes in pediatric intensive care unit.
Analysis of 91 cases of nasal endoscopic surgery for nasal and ocular- related diseases
Authors: Qi Hui , Tu Xiang , Xiong Qinglan , Liu Guiqin , Sun Yueqi , Xiong Cheng , Fan Yunping , OuYang Ming
Published: November 2023

The efficacy of nasal endoscopy for nasal and ocular-related diseases remains largely elusive. We retrospectively analyzed the data of 91 patients (158 eyes) with nasal and ocular-related diseases from Feb 2017 to April 2022 were used to analyze the effects of different operations. We demonstrated that the 13 patients (13 eyes) with traumatic optic neuropathy, nine (69.2%) demonstrated improved visual acuity post-operatively. Of the 65 patients (130 eyes) with thyroid-related ophthalmopathy, 120 eyes (92.3%) have less proptosis post-operatively, whereas 10 eyes showed no changes. One case noted worse visual acuity post-operatively, and 20 eyes noted new-onset diplopia. In eight cases (8 eyes) with retroorbital space-occupying lesions, five patients (62.5%) noted visual acuity and visual field improvements post-operatively. We propose that although nasal endoscopic surgery has some limitations in the orbit, it is a safe, effective, and minimally invasive option for nasal and ocular-related conditions. Close collaboration between ophthalmologists and rhinologists is important.