bluuebunny/crossref_metadata_2025 huggingface dataset:
Bipolar affective disorder: A review of novel forms of therapy
Authors: Dziwota Ewelina , Drapala Barbara , Gaj Magdalena , Skoczen Nikodem , Olajossy Marcin
Published: March 2018

Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD). Long-term studies on the mechanisms of action of such medications, as well as on the pathogenetic background of BD, have led to the discovery of effective, albeit unconventional pharmacotherapeutic approaches. These methods have the potential to successfully treat mania and depression, as well as to counter affective episode relapse. Allopurinol - commonly used to treat gout, secondary hyperuricemia and Lesch-Nyhan syndrome, acts by inhibiting the synthesis of uric acid, levels of which are often increased in manic patients. Due to this, an evaluation of the potential effect of allopurinol on the reduction of mania symptoms seems to be reasonable. Additionally, the numerable research papers coming out of research regarding the role of purine neurotransmitters in mood alterations, indicate that adenosine agonists act analogously to dopamine antagonists.

N-acetylcysteine (NAC), a supporting agent in the pharmacotherapy of depressive episodes in bipolar disorder, substantially accelerates mood stabilization in patients. In turn, memantine, known for its procognitive effect, not only has antimanic and normothymic properties, but also boosts the neuroprotective action of traditional lithium therapy.

In view of the latest opinions, the subtle pro-inflammatory process is typical for the pathophysiology of bipolar disease. Acetylsalicylic acid (ASA) (a popular analgesic, antipyretic and antiphlogistic agent) may be useful in BD therapy. This is because that, via its effect upon cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), ASA modulates leukocyte recruitment in neuro-inflammation.

Apart from the above-mentioned medications, this article introduces the results of recent investigations of ketamine, modafinil and tamoxifen, including their receptor mechanisms, as well as certain genetic aspects or elements of their pharmacodynamics, for use in BD therapy. We put forward that, possibly, more insightful cognition of these drugs will allow significant enrichment in the range of pharmacotherapy for BD in the near future.
Retention behavior of selected alkaloids in Reversed Phase micellar chromatographic systems
Authors: Petruczynik Anna , Noster Grzegorz , Waksmundzka-Hajnos Monika
Published: March 2018

In this work, the effects of sodium dodecyl sulfate (SDS) concentrations on retention, separation selectivity, peak shapes and systems efficiency were investigated. Herein, the retention data for 11 alkaloids were determined on an RP18 silica column with mobile phases containing methanol as organic modifier, with acetate buffer at pH 3.5, and, subsequently, with the addition of sodium dodecyl sulfate (SDS). The results of this study indicate that the retention of alkaloids decreases with the increase of SDS concentration in the mobile phase. The increase of SDS concentration, however, leads to the significantly improvement of peak symmetry and the increase of theoretical plate number in all cases. The best system efficiency for most of the investigated alkaloids was obtained in a mobile phase containing 0.1 M SDS, while most symmetrical peaks were obtained through the addition of 0.3 M of SDS to the mobile phase.
Demographic variability indicators of somatically healthy men from different administrative and territorial regions of Ukraine
Authors: Mishalov Volodymyr , Klimas Larisa , Gunas Valery
Published: March 2018

Our work has revealed a rather low level of similarity in regard to the finger dermatoglyphics of somatically healthy men, 19-35 years old, between Ukraine’s north and west, north and south, center and west, center and south, as well as the palmar dermatoglyphics between central regions and the east, center and west, center and south. The obtained finger/palmar dermatoglyphics did not differentiate administrative-territorial local groups of men between the north and the center, south and west (quantitative characteristics); or palmar – between the north and west, north and east, south and west, south and east, north and center. The differences between the administrative and territorial division of dermatoglyphic signs are a reflection of the historical and cultural differences induced by migration, as well as the intensive process of mixing, in addition to the isolation of particular groups.
The use of a freeze-dried extract of Ligusticum mutellina in a cosmetic cream with potential antioxidant properties
Authors: Tomasz Baj , Elwira Sieniawska , Bartłomiej Kubiak , Danuta Partyka
Published: March 2018

The aim of this work was to develop a cream formulation with potential antioxidant properties. Herein, a freeze-dried extract of Ligusticum mutellina was used as a source of active compounds. The proposed qualitative composition of the cream was characterized by a good polyphenolic compounds release profile. Of note, the highest R2adj values were obtained for the Korsmeyer-Peppas and Higuchi models (0.9159 and 0.9226, respectively). These results indicate that a freeze-dried extract of L. mutellina, due to its retained high phenolic acids content, could become a key component in antioxidant creams.
Gastric neuroendocrine tumor treated with endoscopic submucosal dissection
Authors: Bojar Pawel , Swatek Jaroslaw , Drabko Jaroslaw , Golec Katarzyna , Ostrowska Anna , Szumilo Justyna
Published: March 2018

A case of a 59-year-old male patient with gastric neuroendocrine tumor which was misdiagnosed as adenocarcinoma, is presented. Herein, primary diagnosis was made due to the similarity of endoscopic pictures of both diseases and dues to the inappropriate interpretation of a small biopsy sample. The patient was qualified for endoscopic submucosal dissection. Microscopic examination of whole lesion, supplemented by immmunohistochemical reactions (chromogranin A, synaptophysin, cytokeratins 7 and 20, Ki67) revealed gastric neuroendocrine tumor (NET) G2.

The lesson learnt is that to provide effective treatment to the patient, it is necessary to use all available methods to make a proper diagnosis and to distinguish the suspected disease from others with similar features.
Energy drinks – consumption and awareness among students of Medical University of Lublin
Authors: Cencek Piotr , Wawryk-Gawda Ewelina , Samborski Patryk , Jodlowska-Jedrych Barbara
Published: March 2018

Energy drinks (ED), containing caffeine, taurine and another substances, are one of the more frequently used legal stimulants. Still, because these can endanger consumers’ health, it is thought that their marketing should be legally controlled.

In our study, we analyzed the frequency of energy drink consumption, as well as the knowledge held about these drinks among medicine and dentistry students of the Medical University of Lublin. In the study, 131 students participated, and the study was done in the form of a survey. The results of this indicate that 81 students (61.83%) declared a daily consumption, and most respondents (78.48%) stated at least a one time consumption of 250 to 749 ml of energy drink. What is more, 26.25% of respondents combined ED with other substances, most frequently with coffee and alcohol. Regarding knowledge of ED effects, contents and side effects, more males than females actively sought and held this information. Furthermore, more than half of all respondents believed that the availability of EDs in Poland should be limited.

Our study showed that the awareness of the effects and mechanisms of action of EDs, among the questioned students is relatively high. Nevertheless, they frequently consume EDs and combine these with other stimulants.
Relating the Electrical Resistance of Fresh Concrete to Mixture Proportions
Authors: Obla K. , Hong R. , Sherman S. , Bentz D. P. , Jones S. Z.
Published: March 2018

Characterization of fresh concrete is critical for assuring the quality of the United States’ constructed infrastructure. While fresh concrete arriving at a job site in a ready-mixed concrete truck is typically characterized by measuring temperature, slump, unit weight, and air content, here the measurement of the electrical resistance of a freshly cast cylinder of concrete is investigated as a means of assessing mixture proportions, specifically cement and water contents. Both cement and water contents influence the measured electrical resistance of a sample of fresh concrete: the cement by producing ions (chiefly potassium, sodium, and hydroxide) that are the main source of electrical conduction and the water by providing the main conductive pathways through which the current travels. Relating the measured electrical resistance to attributes of the mixture proportions, such as water-cement ratio by mass (w/c), is explored for a set of eleven different concrete mixtures prepared in the laboratory. In these mixtures, w/c, paste content, air content, fly ash content, high range water reducer dosage, and cement alkali content are all varied. Additionally, concrete electrical resistance data are supplemented by measuring the resistivity of its component pore solution obtained from five laboratory-prepared cement pastes with the same proportions as their corresponding concrete mixtures. Only measuring the concrete electrical resistance can provide a prediction of the mixture’s paste content or the product w*c; conversely, when pore solution resistivity is also available, w/c and water content of the concrete mixture can be reasonably assessed.
Rheological Characteristics of Fine-Grained Soil-Slurries
Authors: Shetty Rakshith , Singh Devendra Narain
Published: March 2018

Various natural and man-made scenarios such as rainfall-induced terrestrial landslides, offshore landslides, mudflows, and transportation of mud by pipelines and dredging activities involve fine-grained soils, minerals, and sediments with very high moisture contents (i.e., the slurry state). Presumably, the behavior of these materials in their slurry state falls within a transition between the solid-dominant and liquid-dominant zones. Hence, investigations to establish the rheological properties of these materials (i.e., defining their flow and deformation characteristics) in this transition phase become mandatory. With this in view, investigations were conducted to establish the grain-water interaction that would govern the rheological characteristics of these materials in their slurried states. The study takes into account the effect of state parameters like water content, w (which is indicative of the concentration of solids), and soil-specific parameters (viz, mineralogy, liquid limit [LL], specific surface area [SSA], and the pore solution characteristics). Based on a critical analysis of the variation of the plastic viscosity, ηp, with respect to w, a hypothesis for the phase-transition mechanism of the slurries, from visco-plastic to ideal-plastic regime, has been proposed. It has been demonstrated that such a hypothesis facilitates understanding of the grain-water interaction for a wide range of water content and associated changes in the rheological behavior. Furthermore, it has been demonstrated that there exists a unique relationship between ηp and yield stress, τy, with the parameter “normalized water content,” wn (= w/LL), for these materials. It is the authors’ belief that these relationships would be useful in obtaining parameters such as slurry viscosity, yield stress, and optimal/limiting water content, which are required in the design of various industrial applications involving flow, the pumping of fine-grained soil-slurries, or both.
Numerical Simulation of Pervious Concrete Using Discrete Element Modeling Technique
Authors: Singh Surya Pratap , Biligiri Krishna Prapoorna
Published: March 2018

The objective of this study was to develop a computational model to simulate the behavior of pervious concrete (PC) material. A virtual discrete model will help in understanding the micro- and macro-mechanical behavior of PC, which is otherwise difficult to determine. A particle flow continuum model was used to develop the discrete model for different pervious PC mixtures consisting of different sizes and proportions of coarse aggregates. The displacement versus force and stress versus strain relationships of PC specimens with different aggregate sizes, aggregate-cement ratios, and water-cement ratios were produced from the numerical models. The vertical porosity distribution of laboratory samples was investigated using image analysis techniques. The results from the image analyses were utilized in modeling exercise through Particle Flow Code 2-Dimensional (PFC2D). The PFC2D model predictions also matched well with the results of mechanical tests with very high coefficient of determination. This research demonstrated the great potential of discrete element method to analyze the performance of PC mixtures with varying gradations and properties. It is envisaged that this study will further the state-of-the-art analytical research in the area of PC by the principles of discrete element model methods and image analyses techniques.
Dopamine D2 Receptors in Dopaminergic Neurons Modulate Performance in a Reversal Learning Task in Mice
Authors: Linden Jérôme , James Alexander S. , McDaniel Colin , Jentsch J. David
Published: March 2018

Neuroimaging studies in animal models and human subjects have each revealed that relatively low striatal dopamine D2-like receptor binding potential is associated with poor impulse control and with vulnerability for addiction-related behaviors. These studies cannot, however, disambiguate the roles for various pools of D2 receptors found in the striatum (e.g., those expressed on medium spiny striato-pallidal neurons vs on dopamine-releasing nerve terminals) in these behavioral outcomes. To clarify the role of the latter pool, namely, D2 autoreceptors, we studied mice carrying a conditional DRD2 gene, with or without Cre-recombinase expressed under the transcriptional control of the dopamine transporter gene locus (autoDrd2-KO,n= 19 and controls,n= 21). These mice were tested for locomotor response to cocaine, and spatial reversal learning was assessed in operant conditioning chambers. As predicted, compared to control mice, autoDrd2-KO animals demonstrated heightened sensitivity to the locomotor stimulating effect of cocaine (10 mg/kg, i.p.), confirming previous research using a similar genetic model. In the spatial reversal learning task, autoDrd2-KO mice were slower to reach a learning criterion and had difficulty sustaining a prolonged nose poke response, measurements conceptually related to impaired response inhibition. Rate of learning of the initial discrimination and latencies to collect rewards, to initiate trials and to produce a response were unaffected by genetic deletion of D2 autoreceptors, discarding possible motor and motivational factors. Together, these findings confirm the role of D2 autoreceptors in reversal learning and suggest a broader involvement in behavioral inhibition mechanisms.
Implementing Goal-Directed Foraging Decisions of a Simpler Nervous System in Simulation
Authors: Brown Jeffrey W. , Caetano-Anollés Derek , Catanho Marianne , Gribkova Ekaterina , Ryckman Nathaniel , Tian Kun , Voloshin Mikhail , Gillette Rhanor
Published: March 2018

Economic decisions arise from evaluation of alternative actions in contexts of motivation and memory. In the predatory sea-slugPleurobranchaeathe economic decisions of foraging are found to occur by the workings of a simple, affectively controlled homeostat with learning abilities. Here, the neuronal circuit relations for approach-avoidance choice ofPleurobranchaeaare expressed and tested in the foraging simulation Cyberslug. Choice is organized around appetitive state as a moment-to-moment integration of sensation, motivation (satiation/hunger), and memory. Appetitive state controls a switch for approach vs. avoidance turn responses to sensation. Sensory stimuli are separately integrated for incentive value into appetitive state, and for prey location (stimulus place) into mapping motor response. Learning interacts with satiation to regulate prey choice affectively. The virtual predator realistically reproduces the decisions of the real one in varying circumstances and satisfies optimal foraging criteria. The basic relations are open to experimental embellishment toward enhanced neural and behavioral complexity in simulation, as was the ancestral bilaterian nervous system in evolution.
Julius Stockhausen's Early Performances of Franz Schubert's Die schöne Müllerin
Authors: Loges Natasha
Published: March 2018

Franz Schubert's song cycle Die schöne Müllerin makes enormous demands not only on the performers but also on its audience, a factor that shaped the early performance history of the work. In this article, the pioneering complete performances of Die schöne Müllerin by the baritone Julius Stockhausen (1826–1906) will be explored, as well as the responses of his audiences, collaborators, and critics. The circumstances surrounding the first complete performance in Vienna's Musikverein on 4 May 1856, more than three decades after the cycle was composed in 1823, will be traced. A survey of subsequent performances reveal two things: within Stockhausen's concert career at least, it was no foregone conclusion that the complete cycle should always be performed; and a performance of the “complete cycle” meant many different things in his day. Stockhausen's artistic idealism jostled against the practical forces that necessarily influenced his approach to recital programming, leading to a multifaceted, untidy performance history for this cycle.
Cardiovascular outcomes trials with statins in diabetes
Authors: Naeem Fariha , McKay Gerard , Fisher Miles
Published: March 2018

Treatment with statins is one of the most effective ways of reducing cardiovascular events in those with diabetes. Many studies containing thousands of subjects with diabetes have demonstrated that statins reduce cardiovascular events when there is no known cardiovascular disease (primary prevention) and in those with confirmed atherosclerotic disease (secondary prevention). High-dose statins appear to be even more effective in established cardiovascular disease, but at the expense of increased drug side effects. In this paper we review the evidence for the benefits of statins in diabetes. In a second review we will examine the evidence for possible benefits of other lipid-lowering therapies when these are added to background statin therapy in diabetes.
La responsabilidad civil de las entidades de certificación en Colombia
Authors: Torres Torres Ana Yazmin , Ramírez Arenas Oduber Alexis
Published: March 2018

Las entidades de certificación creadas por la Ley 527 de 1999 llevan a cabo diversas actividades, como son, entre otras, las de emitir certificados en relación con las firmas electrónicas o digitales de personas naturales o jurídicas y emitir certificados sobre la verificación respecto a la alteración entre el envío y recepción del mensaje de datos y de documentos electrónicos transferibles; actividades que deben ser cumplidas a cabalidad por las entidades de certificación, pues de no hacerlo, se afectan los derechos de los suscriptores. De acuerdo con el régimen de responsabilidad civil, las entidades de certificación están en la obligación de responder por todos los perjuicios que causen en el cumplimiento de sus funciones, por los perjuicios que puedan causar a los suscriptores y a terceros de buena fe.
La fuerza vinculante de la jurisprudencia del Consejo de Estado
Authors: Vargas Florián Sandra Mercedes
Published: March 2018

La jurisprudencia constitucional es considerada como fuente formal y material del derecho en el sistema jurídico colombiano, de ahí procede su fuerza vinculante en las decisiones de las autoridades judiciales y administrativas. Este reconocimiento, derivado de la función judicial de la Corte Constitucional, no se da en la jurisdicción de lo contencioso administrativo, toda vez que el Consejo de Estado no se ha ocupado de una acuciosa expedición, recopilación y publicación de sentencias con carácter vinculante. Esta investigación enfoca su atención en la jurisdicción de lo contencioso administrativo y en el carácter vinculante de la jurisprudencia emanada del Consejo de Estado. Son estudiadas aquí nuevas figuras jurídicas contempladas en la Ley 1437 de 2011, tales como el deber de aplicación uniforme de la jurisprudencia, la extensión de la jurisprudencia del Consejo de Estado a terceros por parte de las autoridades, el recurso extraordinario de unificación de la jurisprudencia y las sentencias de unificación.Se establece el carácter vinculante que ostentan las sentencias de unificación proferidas por el Consejo de Estado de conformidad con esta ley. Además se muestra cómo, si se logra la aplicación de las nuevas figuras y los procedimientos estudiados, se contribuirá al reconocimiento de la fuerza vinculante de la jurisprudencia emanada del Consejo de Estado, a la descongestión judicial y a la protección de valores importantes del sistema jurídico, así como a la igualdad de trato y seguridad jurídica en materia de lo contencioso administrativo.
Inseguridad jurídica ante el impedimento del ejercicio de la acción pública de inconstitucionalidad dentro del proceso especial para la paz
Authors: Joya Rojas Diana Marcela , Sánchez Muñoz Angye Nathalia
Published: March 2018

El presente trabajo investigativo pretende identificar en qué medida los actos legislativos que son expedidos bajo el procedimiento especial para la paz, generan seguridad jurídica, en aras de que su control de constitucionalidad solo se realiza por vicios de procedimiento en su formación y de oficio, sin permitir que se pueda incoar por parte del ciudadano la acción pública de constitucionalidad; razón por la cual se hace necesario establecer la naturaleza jurídica de dichos actos legislativos y determinar el proceso de constitucionalidad, de conformidad con lo establecido por la Corte Constitucional, así mismo, se evidencia que este desbalance jurídico tiene solución a través de la emisión de diferentes tipologías de sentencias que puede realizar la Corte Constitucional, con el fin de ejercer un control material y formal sobre dichos actos reformatorios, siendo en el caso concreto la expedición de una sentencia que interprete y adicione la implementación del acuerdo de paz, con el propósito de garantizar el poder constituyente primario, y la democracia participativa como característica fundamental de un Estado social, constitucional y democrático de derecho.
Loci That Control Nonlinear, Interdependent Responses to Combinations of Drought and Nitrogen Limitation
Authors: Chang Megan M , Nail Danielle Allery , Kazic Toni , Simmons Susan J , Stapleton Ann E
Published: March 2018

Crop improvement must accelerate to feed an increasing human population in the face of environmental changes. Including anticipated climatic changes with genetic architecture in breeding programs could better optimize improvement strategies. Combinations of drought and nitrogen limitation already occur world-wide. We therefore analyzed the genetic architecture underlying the response of Zea mays to combinations of water and nitrogen stresses. Recombinant inbreds were subjected to nine combinations of the two stresses using an optimized response surface design, and their growth was measured. Three-dimensional response surfaces were fit globally and to each polymorphic allele to determine which genetic markers were associated with different response surfaces. Three quantitative trait loci that produced nonlinear surfaces were mapped. To better understand the physiology of the response, we developed a model that reproduced the shapes of the surfaces, their most characteristic feature. The model contains two components that each combine the nitrogen and water inputs. The relative weighting of the two components and the inputs is governed by five parameters, and each QTL affects all five parameters.

We estimated the model’s parameter values for the experimental surfaces using a mesh of points that covered the surfaces’ most distinctive regions. Surfaces computed using these values reproduced the experimental surfaces well, as judged by three different criteria at the mesh points. The modeling and shape comparison techniques used here can be extended to other complex, high-dimensional, nonlinear phenotypes. We encourage the application of our findings and methods to experiments that mix crop protection measures, stresses, or both, on elite and landrace germplasm.
Genetic Basis of Body Color and Spotting Pattern in Redheaded Pine Sawfly Larvae (Neodiprion lecontei)
Authors: Linnen Catherine R , O’Quin Claire T , Shackleford Taylor , Sears Connor R , Lindstedt Carita
Published: March 2018

Pigmentation has emerged as a premier model for understanding the genetic basis of phenotypic evolution, and a growing catalog of color loci is starting to reveal biases in the mutations, genes, and genetic architectures underlying color variation in the wild. However, existing studies have sampled a limited subset of taxa, color traits, and developmental stages. To expand the existing sample of color loci, we performed QTL mapping analyses on two types of larval pigmentation traits that vary among populations of the redheaded pine sawfly (Neodiprion lecontei): carotenoid-based yellow body color and melanin-based spotting pattern. For both traits, our QTL models explained a substantial proportion of phenotypic variation and suggested a genetic architecture that is neither monogenic nor highly polygenic. Additionally, we used our linkage map to anchor the current N. lecontei genome assembly. With these data, we identified promising candidate genes underlying (1) a loss of yellow pigmentation in populations in the mid-Atlantic/northeastern United States [C locus-associated membrane protein homologous to a mammalian HDL receptor-2 gene (Cameo2) and lipid transfer particle apolipoproteins II and I gene (apoLTP-II/I)], and (2) a pronounced reduction in black spotting in Great Lakes populations [members of the yellow gene family, tyrosine hydroxylase gene (pale), and dopamine N-acetyltransferase gene (Dat)]. Several of these genes also contribute to color variation in other wild and domesticated taxa. Overall, our findings are consistent with the hypothesis that predictable genes of large effect contribute to color evolution in nature.
Islamic Clicktivism: Internet, Democracy and Contemporary Islamist Activism in Surakarta
Authors: Ahyar Muzayyin
Published: March 2018

Since the collapse of the New Order regime, social development has led Indonesia to become a more democratic and modern than any other Muslim majority countries. The development of democracy in Indonesia has also seen the proliferation of modern Islamist activism online. This form of cyber activism, named here as Islamic “clicktivism,” has a discursive function. This paper examines how the proliferation of a cyber Islamist movement can be related to ongoing democratization in Indonesia. It was found that Islamic clicktivism has emerged in the process of democratization, modernization and globalization. Clicktivism encourages members of Islamist groups to adopt the principles and logic of the pillars of democracy, and to perpetuate their struggle and promote their existence during the development of democracy in Indonesia. Through their clicktivism, they bring the discursive voices of Islamism democratically to national issues in the common interest of Indonesians.DOI: 10.15408/sdi.v24i3.4859
Al-Ṣumūd wa al-takayyuf wa al-tathāquf: Ta‘bīr ‘an huwīyat al-‘ulamā’ fī al-manfá bi Kampung Jawa Tondano
Authors: Syahid Achmad
Published: March 2018

The disturbing, destructive and detrimental religious-political relations between Muslim warriors, kings or sultans, princes, and the santri Muslims in the archipelago during the VOC and Dutch colonial era, were not the same throughout Indonesia. Islamic relations with colonial rulers with high tension and heating up, perceived by Muslims as jihad not only because of the despotic ruler factor but also because of non-Muslim factor. The case of Kampung Jawa Tondano, Minahasa, provides evidence that the three-party social-religious relation, namely Muslim-Christian-colonial ruler, is unlike in other parts of Indonesia. This study came to the conclusion that the Muslim warriors in Kampung Jawa Tondano have a good ability in adaptation, acculturation and resilience while still embracing Islam, performing rituals, keep their religious identity and traditions in their daily life, but maintaining good relations with Christians despite refusing to accommodate with the Dutch.DOI: 10.15408/sdi.v24i3.6173
Syaikh Dā’ūd al-Faṭānī dan Hubungan Mekah-Asia Tenggara: Jaringan Intelektual, Transmisi Islam dan Rekonstruksi Sosio-Moral
Authors: Burhanudin Jajat
Published: March 2018

Francis R. Bradley. 2016. Forging Islamic Power and Place: The Legacy of Shaykh Dā’ūd ‘Abd Allāh al-Faṭānī in Mecca and Southeast Asia. Honolulu: University of Hawaii Press. 212 pp.This book presents the discussion on Malay Muslim of Patani in southern Thailand today. Taking the social and intellectual life of the father of Patani ‘ulama, Syaikh Dā’ūd ‘Abd Allāh al-Faṭānī (1769-1847), as the main subject of research, this book reveals an important period of Patani history when intellectual activities, centred in Mecca, were transformed into social and moral power for their revival in the 19th and early 20th centuries. The fall of Patani kingdom into the Siamese power in 1786 led the rise of new elites coming from religious circles, the ‘ulama. Under the influence of Syaikh Dā’ūd al-Faṭānī, the ‘ulama engaged in intellectual network and transmission of currently Meccan-based discourses, mainly those in the works of Syaikh Dā’ūd al-Faṭānī, to Patani and Malay peninsula. And this process was strengthened with the rise of pondok, traditional Islamic learning centre, providing the Muslims of Patani with new social and cultural capital for their struggle for identity in the courses of  development.DOI: 10.15408/sdi.v24i3.6215
Protecting Rights of Children With Medical Complexity in an Era of Spending Reduction
Authors: Perkins Jane , Agrawal Rishi
Published: March 2018

Children with medical complexity (CMC) often require multiple services across the continuum of care, such as therapies and home nursing. However, sufficient access to needed services is not assured and varies considerably by payer, many of whom who face pressures to control health spending. In this article, we review the rights of CMC in Medicaid, the Children’s Health Insurance Program, and various forms of private health insurance to receive services that are necessary to promote optimal health, development, and family functioning. Controlling laws such as the Americans with Disabilities Act and the Early and Periodic Screening, Diagnostic, and Treatment provisions of the Medicaid Act are discussed, and precedential court decisions affecting CMC are reviewed. Implications for policy, advocacy, and payment model design are explored in the context of current emphasis on spending reduction.
Ethical Framework for Risk Stratification and Mitigation Programs for Children With Medical Complexity
Authors: Feudtner Chris , Schall Theodore , Nathanson Pamela , Berry Jay
Published: March 2018

Those in hospitals and health care systems, when designing clinical programs for children with medical complexity, often talk about needing to develop and implement a system of risk stratification. In this article, we use the framework of an ethical evaluation of a health care program to examine what this task of risk stratification might entail by identifying specific and detailed issues that require particular attention and making a series of recommendations to help ensure that programs for children with medical complexity avoid potentially ethically problematic situations and practices.
EFEKTIVITAS METODE APLIKASI VAKSIN TRIVALEN UNTUK PENCEGAHAN PENYAKIT BAKTERI POTENSIAL PADA BUDIDAYA IKAN AIR TAWAR
Authors: Taukhid Taukhid , Sumiati Tuti , Andriyanto Septyan
Published: March 2018

Penelitian ini bertujuan untuk mendapatkan metode aplikasi vaksin trivalen yang memberikan level proteksi terbaik untuk pencegahan penyakit bakteri potensial; motile aeromonas septicemia (MAS), streptococcosis, dan mycobacteriosis pada budidaya ikan air tawar. Vaksin trivalen yang dicobakan merupakan campuran dari tiga jenis antigen, yaitu Aeromonas hydrophila-AHL0905-2 (Ah), Streptococcus agalactiae N14G (Sa), dan Mycobacterium fortuitum 31 (Mf) dengan formulasi 2 Ah : 2 Sa : 1 Mf (v/v). Ikan uji yang digunakan adalah ikan lele, nila, dan gurami; masing-masing jenis ikan tersebut merupakan representasi ikan yang rentan terhadap penyakit MAS, streptococcosis, dan mycobacteriosis. Perlakuan yang diterapkan adalah metode aplikasi dengan menggunakan vaksin trivalen melalui: (A) perendaman, (B) pakan, (C) perendaman + booster, (D) pakan + booster, dan (E) tanpa pemberian vaksin sebagai kontrol. Efektivitas metode aplikasi vaksin tersebut dievaluasi melalui nilai titer antibodi spesifik dan relative percentage survival (RPS) pasca uji tantang terhadap patogen target. Hasil penelitian menunjukkan bahwa RPS dari metode aplikasi vaksin trivalen pada ketiga jenis ikan uji yang mencapai nilai ³ 50% secara keseluruhan hanya diperoleh pada aplikasi melalui rendam + booster. Oleh karena itu, metode aplikasi tersebut dapat direkomendasikan untuk digunakan pada pembudidaya ikan air tawar.This study aims to obtain a method of application of trivalent vaccine that gives the best level of protection for prevention of potential bacterial diseases such as motile Aeromonas septicemia (MAS), streptococcosis, and ycobacteriosis in freshwater fish culture. The trivalent vaccine is a mixture of three types of antigens, namely Aeromonas hydrophila-AHL0905-2 (Ah), Streptococcus agalactiae N14G (Sa), and Mycobacterium fortuitum 31 (Mf) with the formulation of 2 Ah: 2 Sa: 1 Mf (v / v). The test fish used were catfish, tilapia, and giant gourami; each fish is a representation of fish vulnerable to MAS, streptococcosis, and mycobacteriosis. The applied treatments were the application methods of trivalent vaccine through (A) immersion, (B) feed, (C) immersion + booster, (D) feed + booster, and (E) without vaccine as the control. The effectiveness of vaccine application methods was evaluated through the value of specific antibody titer and relative percentage survival (RPS) post-challenge test against the target pathogens. The results showed that overall, the RPS value of > 50% on all three test fish species was obtained only by the vaccine application through soak + booster. Therefore, the application method can be recommended to be used in freshwater fish culture.
L2 English learning books under analysis
Authors: Zarco-Tejada Maria Angeles
Published: March 2018

In this study we have addressed how cohesion is achieved in L2 oral English learning materials focusing our study on the analysis of conjunctions. We have checked if cohesion is gradually accomplished according to levels of proficiency and if the use of conjunctions in upper level learning materials resembles native speaker standards. Our study proves that cohesion is gradually achieved by L2 oral English learning materials but that proficiency level distinctions based on cohesion cannot be explained in terms of cohesive variables quantitative measures only, but on the combination of statistical results plus qualitative cohesive devices criteria. Our study uses Coh-Metrix and AntConc as computational tools and compares outputs with the British National Corpus (BNC) which shows how ranks of use of cohesive procedures from authentic oral texts should guide learning material makers.
The tattooed doctor: An exploration of the perceptions of medical students and medical school staff
Authors: Callaghan Ben , McConville Kevin
Published: March 2018

This article was migrated. The article was marked as recommended. Objective: This study explored the perceptions of medical students and medical school staff towards tattoos. Background: As tattooing continues to become more of a mainstream practice, and with the lack of clarity provided by the General Medical Council on the topic, research to inform policy makers at a national and local level is merited. Methods: A case study was implemented to facilitate the exploration of the perceptions of tattoos. Focus groups and semi-structured interviews were used for students and staff respectively for data collection. The results underwent thematic analysis according to Braun and Clarke's guidance. Results: Medical students and medical school staff had broadly similar perceptions of tattoos. Four main themes were identified: the nature of tattoos, professionalism, freedom of expression and generational perceptions.
We All Came From Somewhere
Authors: Coombes Elizabeth
Published: March 2018

This reflection on practice concerns a short-term music therapy project undertaken in 2014 with asylum seeking families in a major city in S. Wales. The project was designed to support these families in settling in their new home, and was the first music therapy initiative for the charity who funded it. The work itself caused the therapist to reflect on the countertransference engendered by the experience and how this aspect of the work enabled her to gain a deeper understanding of issues faced by those who find themselves seeking asylum in another country.
Music Therapy and Recovery in Mental Health: Seeking a Way Forward
Authors: McCaffrey Tríona , Carr Catherine , Solli Hans Petter , Hense Cherry
Published: March 2018

As recovery is a prevailing vision for modern mental health services internationally, it is timely to consider its current state of play in relation to music therapy practice. This paper offers a theoretical perspective of this topic, by presenting the views of four music therapy researchers situated in Australia, Ireland, Norway, and the United Kingdom. Each of the four authors completed doctoral research in music therapy in the past three years that is explicitly about, or related to, recovery in mental health. Collectively all authors have considerable experience of providing individual and group music therapy services in acute and community settings with adults and adolescents within recovery-oriented services. This article aims to elaborate on the implications of music therapy as a recovery-oriented practice, while presenting recommendations as to how music therapy can maximize support for recovery for our patients and service users. It draws on our respective doctoral study findings and lived experience of offering music therapy in recovery-oriented services, so as to present a collective theoretical perspective to other music therapy practitioners who are interested in this growing area. By doing so we hope to encourage discussion and response from music therapists practising in various mental health contexts in the service of developing the best possible music therapy services to our patients and service users.
Handoff communication in intensive care: links with patient safety
Authors: Santos Grazielle Rezende da Silva dos , Campos Juliana Faria , Silva Rafael Celestino da
Published: March 2018

Abstract Objective: To gather scientific evidence about ICU handoff practices and their implications on the safety of communication among team members about hospitalized patients. Method: This was an integrative review conducted in the Medline, PubMed, Cinahl and Scopus databases with the descriptors patient handoff, communication, patient safety, critical care, health communication and intensive care unit. The adopted criteria were: full text, in Portuguese or English, in the last 10 years, with level of evidence over IV and compliance to the study question. Fifteen articles were submitted to a structured tool and analysis. Results: There is evidence of incompleteness, absence or errors in handoff information, caused by the lack of standardization and preparation for this activity, generating delayed, incorrect or non-performed procedures. The use of tools reduces the amount of omitted information, side talks, and errors, improving team satisfaction. Final considerations: It is necessary to promote safe communication in handoff, implementing practices that ensure care continuity.
Sustainability rating tools for highway projects: the nature and outcomes of use
Authors: Griffiths Kerry , Boyle Carol , Henning Theunis F P
Published: March 2018

Sustainability rating tools for civil infrastructure including highways are increasing in use. The Ceequal scheme has been operating in the UK for around 14 years with over 360 project ratings awarded. The Greenroads, Envision and Infrastructure Sustainability schemes are growing in use in the USA and Australasia – collectively awarding close to 90 projects since 2012. What opportunities do these rating tools present for asset managers to better drive performance in terms of the social, environmental and economic impacts of infrastructure development? What progress have they made so far? This study draws on the analysis of the rating schemes used by industry today and, in particular, examines the realities of tool use by way of published case studies and interviews with rating tool users and asset owners in Australia, New Zealand, the UK and North America. Project data and user perspectives reveal details on the international use of rating tools and highlight aspects of tool bias and associated challenges in tool selection and comparison, access to performance benchmarking and the reporting of sustainability outcomes particularly for public infrastructure assets.
EFFECT OF BIRTH PREPERATION TRAINING ON PRENATAL ATTACHMENT AND DEPRESSION
Authors: AYDIN KARTAL Yasemin , KARAMAN Tuğba
Published: March 2018

Objective:
This study is conducted to specify the effects of birth preperation training on
the depression risk of pregnant women and their prenatal attachment levels.Method: This
semi-experimental designed  single group
pretest-posttest study was conducted with 44 pregnant women attending the
prenatal preparatory class of a public hospital. In the data collection process
of the study, Pregnancy Presentation Form, Prenatal Attachment Inventory (PBI),
Beck Depression Inventory (BDI) were used . The data were collected through
interview method by the researchers.Results The
mean for the age of the participants is 26,29±4,34, for the mean of the
participants gestational week is 30,47±3,00, for the gestational observation
number is 8,06±2,33. The average BDI score before participating in the birth
preparation class is is 14.77 ± 7,40, the mean PBI score is 59,90 ± 12,40. The
mean BDI score of the participants after participating in the birth preparation
class is 8.06 ± 5.26. The mean PBI score is 71,88 ± 8.25. Prenatal attachment
was found  high in women who were planned
pregnant, nuclear family
and working women  and the risk of
depression was found low in multiparous women,

Conclusion: It
has been observed that birth preperation training decreases the depression risk
of the pregnant women and increased the level of mother-baby attachment.
The Strategy to Support HTGR fuels for The 10 MW Indonesia's Experimental Power Reactor (RDE)
Authors: Taryo Taswanda , Ridwan Ridwan , Sunaryo Geni Rina , Rachmawati Meniek
Published: March 2018

The Indonesia’s 10 MW experimental power reactor (RDE) is developed based on high temperature gas-cooled reactor (HTGR) and the program of the RDE was firstly introduced to the Agency for National Development Planning (BAPPENAS) at the beginning of 2014. The RDE program is expected to have positive impacts on community prosperity, self-reliance and sovereignty of Indonesia. The availability of RDE will be able to accelerate advanced nuclear power technology development and hence elevate Indonesia to be the nuclear champion in the ASEAN region. The RDE is expected to be operable in 2022/2023. In terms of fuel supply for the reactor, the first batch of RDE fuel will be inclusive in the RDE engineering, procurement and construction (RDE-EPC) contract for the assurance of the RDE reactor operation from 2023 to 2027. Consideration of RDE fuel plant construction is important as RDE can be the basis for the development of reactors of similar type with small-medium power (25 MWe–200/300 MWe), which are preferable for eastern part of Indonesia. To study the feasibility of the construction of RDE fuel plant, current state of the art of the R&D on HTGR fuel in some advanced countries such as European countries, the United States, South Africa and Japan will be discussed and overviewed to draw a conclusion about the prospective countries for supporting the fuel for long-term RDE operation. The strategy and roadmap for the preparation of the RDE fuel plant construction with the involvement of national stakeholders have been developed. The best possible vendor country to support HTGR fuel for long-term operation is finally accomplished. In the end, this paper can be assigned as a reference for the planning and construction of HTGR RDE fuel fabrication plant in Indonesia.Keywords: RDE, Indonesia, HTGR, fuel, strategy.
BEDEN EĞİTİMİ VE SPOR ÖĞRETMENLERİNİN SORUNLARI VE PERFORMANSLARINA ETKİLERİ (SAKARYA İLİ ÖRNEĞİ)
Authors: Kul Murat , Hergüner Gülten
Published: March 2018

Bu araştırma eğitimin etkili,
verimli ve vazgeçilmez bir parçası olan beden eğitimi ve spor öğretmenlerinin
sorunları ve bu sorunların öğretmen performansı üzerine etkilerini incelemek
amacıyla yapılmıştır. Araştırmada öncelikle eğitim, beden eğitimi ve beden
eğitimi ve spor öğretmenlerinin görevleri ile ilgili teorik kaynak taraması
yapılmış ve daha sonra Sakarya ilinde 2006–2007 eğitim öğretim yılında görev
yapan beden eğitimi ve spor öğretmenlerine uygulanan anketten elde edilen
bilgiler değerlendirilmiştir. Uygulanan anket kişisel bilgiler ve sorunlara
katılma ile etkilenme derecelerini belirleyen iki bölümden oluşmuştur. Ankete
toplam 127 beden eğitimi ve spor öğretmeni doğru ve değerlendirilebilir cevap
vermiştir. Yapılan istatistiksel çözümlemelerde anlamlılık düzeyi 0,05 olarak
kabul edilmiştir. Analizler sonucunda beden eğitimi ve spor öğretmenlerinin
sorunlara katılma algılarında cinsiyetleri arasında anlamlı bir farklılık
gözlenmemiştir. Beden eğitimi ve spor öğretmenlerinin mesleki sorunlar, tesis
ve ders kaynakları, okul ve aile ile ilgili sorunlarına katılma düzeylerinde
anlamlılık görülmüş ve performanslarının etkilendiği belirlenmiştir.
MATEMATİK TARİHİNİN ORTAOKUL MATEMATİK DERS KİTAPLARINDAKİ YERİ
Authors: Mersin Nazan , Durmuş Soner
Published: March 2018

Matematik tarihinin dikkatli ve akılcı kullanımı etkili bir
öğretim aracı olabilir. Bunun yollarından biri ise matematik derslerine
matematik tarihini entegre etmekten geçmektedir. Entegre etme yolları
içerisinde ders kitaplarının rolü ise yadsınamaz bir gerçektir. Nitekim ders
kitapları öğretmen ile öğrenci arasında bir köprü özelliği taşımaktadır.
Buradan hareketle bu çalışmada ortaokul matematik dersi kitaplarındaki
matematik tarihi öğeleri araştırılarak matematik tarihi ile ilgili durumları
dersin hangi aşamasında ve hangi öğrenme alanında ele alması, hangi konularla
ilişkilendirdiği ve bu ilişkilendirmede hangi etkinliklere yer vermesi
özelliklerine göre sınıflandırılmıştır. Araştırmada nitel araştırma yöntemi kullanılmış
olup toplamda 6 adet ders kitabı incelemeye tabi tutulmuştur. Analizler
sonucunda ise on dokuz adet matematik tarihi öğesine rastlanmıştır. Bu öğelerin
büyük çoğunluğu beşinci ve altıncı sınıf ders kitaplarında tarihsel notlar
şeklinde yer almıştır. Ders kitaplarında matematik tarihinden yeterince
yararlanılmadığı görülmüştür ve ders kitaplarının matematik tarihi öğeleriyle
zenginleştirilmesi önerilmektedir.