bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic of Patients With COVID-19 Pneumonia Using Passive Medical Microwave Radiometry (MWR)
Authors: Emilov Berik , Sorokin Aleksander , Seiitov Meder , Chubakov Tulegen , Vesnin Sergey , Goryanin Igor
Published: April 2023

Background.
Chest CT is widely regarded as a dependable imaging technique for detecting pneumonia in COVID-19 patients, but there is growing interest in microwave radiometry (MWR) of the lungs as a possible substitute for diagnosing lung involvement.
Aim.
The aim of the study is to examine the utility of the MWR approach as a screening tool for diagnosing pneumonia with complications in patients with COVID-19.
Methods.
Our study involved two groups of participants. The control group consisted of 50 individuals (24 male and 26 female) between the ages of 20 to 70 years who underwent clinical evaluations and had no known medical conditions. The main group included 142 participants (67 men and 75 women) between the ages of 20 to 87 years who were diagnosed with COVID-19 complicated by pneumonia and were admitted to the emergency department between June 2020 to June 2021. Skin and lung temperatures were measured at 14 points, including 2 additional reference points, using a previously established method. Lung temperature data were obtained with the MWR2020 (RTM-01-RES) (MMWR LTD, Edinburgh, UK), a CE Class I device. All participants underwent clinical evaluations, laboratory tests, chest CT scans, MWR of the lungs, and reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2.
Results.
The MWR exhibits a high predictive capacity as demonstrated by its sensitivity of 98.6% and specificity of 84.0%.
Conclusions.
MWR of the lungs can be a valuable substitute for chest CT in diagnosing pneumonia in patients with COVID-19, especially in situations where chest CT is unavailable or impractical.
New Catalysts Based on Carboxylate Sn(IV) Complexes Used in the Oxidation Reaction of 3,5-Di-Tert-Butylcatechol to 3,5- Di-Tert-Butyl-O-Benzoquinone
Authors: Titi Abderrahim , Dahmani Mohamed , Alzahrani Abdullah Y. A. , El Kodadi Mohamed , Ettouhami Mohammed , Yahyi Abderrahmane , Yousfi El Bekkaye , Touzani Rachid
Published: April 2023

It is at the chemistry-biology interface that this work that we have carried out takes place. Indeed, the expected goal is to develop simple molecules, capable of activating the catalytic action of certain metalloenzymes such as tyrosinase. The official name of an enzyme includes the type of reaction catalyzed, the name of the substrates involved. In this work, we carried out the study of the catalytic activity of the complexes of organotin carboxylates synthesized vis-à-vis the oxidation of 3,5-di-tert-butylcatecchol. The results obtained show that the various complexes exhibit good catalytic activity for the oxidation of 3,5-di-tert-butylcatecchol under mild conditions. The complexes that showed good catalytic activity are the compounds C1 and C2.
What Does “ITS” Say About Hybridization in Lineages of Sarsia (Corynidae, Hydrozoa) from the White Sea?
Authors: Prudkovsky Andrey , Vetrova Alexandra , Kremnyov Stanislav
Published: April 2023

Hydrozoans are widely known for their complex life cycles. The life cycle usually includes an asexual benthic polyp, which produces a sexual zooid (gonophore). Here, we performed an extensive analysis of 183 specimens of hydrozoan genus Sarsia from the White Sea and identified four types of gonophores. We also compared the type of gonophore with haplotypes of molecular markers COI and ITS. Analysis of COI sequences recovered that the studied specimens relate to the species S. tubulosa, S. princeps and S. lovenii, and that S. lovenii specimens divide into two COI-haplogroups. More intraspecies genetic diversity was revealed in the analysis of ITS sequences. Sarsia tubulosa specimens divide into two ITS-haplotypes, and presumably, hybrid forms between these lineages were found. For S. lovenii, we identified 14 ITS-haplotypes as a result of alleles separation. Intra-individual genetic polymorphism of ITS-region is most likely associated with intraspecific hybridization between different haplotypes. The diversity of morphotypes is associated with the genetic diversity of the specimens. Thus, we demonstrated that the morphologically variable species S. lovenii is represented in the White Sea by a network of intensively hybridizing haplotypes. Hybridization affects the morphology and maturation period of gonophores and presumably affects the processes of speciation.
Hydrogenation of CO2 to Valuable C2-C5 Hydrocarbons on Mn-Promoted High Surface Area Iron Catalysts
Authors: Zepeda Trino A. , Aguirre Sandra , Galindo-Ortega Yunuen I. , Solís-Garcia Alfredo , Yerga Rufino M. Navarro , Pawelec Bárbara , Fierro-Gonzalez Juan C. , Fuentes And Sergio
Published: April 2023

Mn-promoted bulk iron catalysts with high specific surface area (82-211 m2.g-1) were synthesized by coprecipitation followed by drying under supercritical conditions. The catalysts were tested in the CO2 hydrogenation reaction. The Mn-promoted iron catalysts showed better textural properties than the bare Fe2O3 catalyst, allowing better dispersion of the active phase, easier reduction of iron oxide, better carburization of iron oxides and higher catalytic activity than the bare Fe2O3 catalyst. The best activity results were obtained by catalyst promotion with a very low amount of Mn (Mn/Fe ratio of 0.05). Upon steady-state conditions (T=340 ºC, total pressure of 20 bar and H2/CO2=3), this catalyst showed high CO2 conversion (44.2%) and selectivity to C2-C4 hydrocarbons (68%, olefin to paraffin ratio of 0.54), while the selectivity to C5+ hydrocarbons, CH4 and CO was about 3.2, 38.5 and 5%, respectively. A close correlation was found between catalyst textural properties and CO2 conversion. The most active MnFe-0.05 catalyst shows high stability during 72 h of reaction related to low amount of soft coke formation and catalyst activation through the formation of χ-Fe5C2 phase during the on-stream reaction.
Development of Foam Dressing Containing Eclipta prostrata Leaf Extract and Gelatin
Authors: Hasatsri Sukhontha , Suthi Jariya , Siriwut Nattaporn , Charoensappakit Onjira
Published: April 2023

Developing novel wound dressings containing medicinal plant extracts can have several potential benefits, including improving the therapeutic value of the dressings and reducing the cost of producing wound dressings. In this study, we prepared foam dressing containing Eclipta prostrata leaf extract and gelatin (Eclipta prostrata dressing). Chemical composition was verified using Fourier transform infrared spectroscopy (FTIR), and pore structure was obtained by scanning electron microscopy (SEM). The physical properties, including absorption and dehydration properties, were also evaluated. The chemical properties were measured to determine the pH environment after being submerged with Eclipta prostrata dressings. The results revealed that the Eclipta prostrata dressing had a pore structure with an appropriate pore size (313.25 ± 76.51 µm and 383.26 ± 64.45 µm for the Eclipta prostrata A and Eclipta prostrata B dressings, respectively). The Eclipta prostrata B dressing was more consistent porosity, resulting in a higher absorption capacity and faster dehydration rate. According to physical properties, the Eclipta prostrata B dressing is best used on low-exuding wounds. Furthermore, the Eclipta prostrata A and B dressings make a slightly acidic environment. Therefore, our foam dressing will not interfere wound healing process.
Antimicrobial Activity of Five Calcium Silicate Based Root Canal Sealers Against a Multispecies Biofilm
Authors: Hage Wajih , Karam Sarkis Dolla , Kallassy Mireille , Sfeir Germain , Mallah May , Khalil Issam , Zogheib Carla
Published: April 2023

Even after debridement and chemical root canal preparation, multispecies bacterial biofilms can still be found in root canals and dentinal tubules. This demonstrates the necessity of using suitable antibacterial endodontic sealers. Due to their well-known biological qualities, calcium silicate based root canal sealers or “bioceramic’ sealers have recently been launched and can be successful in endodontic procedures. This study's objective was to compare the impact of CerasealR, Total Fill BC SealerR, Bio-C SealerR, AH Plus BioceramicR, K-biocerR and SealiteR on the elimination of a multispecies’ endodontic biofilm at 3, 7 and 14 days.
Enterococcus faecalis, Pseudomonas Aeruginosa, Candida Albicans and Proteus Mirabilis were cultured on specific agars and later grown in Brain Heart Infusion broth on hydroxyapatite discs pretreated with collagen type 1 and incubated for 18 days. The resulting biofilm was then placed on a 10mm round shaped blotting paper set on a metallic net in a 6cm petri dish with an orthodontic bend filled with the calcium silicate based root canal sealer in direct contact with the biofilm.
In all tested groups, the total bacterial count has significantly decreased between day 3 and day 14 (P<0.05) with no statistically significant differences among the different sealers’ groups at all time points. Sealite group was capable of decreasing the Candida Albicans count significantly between day 3 and day 14 (P<0.05) in comparison with the bioceramic groups.
All sealers had antibacterial activity against the multispecies biofilm between day 3 and day 14.
Renal papillary necrosis as a rare cause of gross hematuria: a case report
Authors:   Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, Kazan, Russian Federation, Shaikhraziev B.M. , Gainetdinov K.I. ,   Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, Kazan, Russian Federation, Teregulov A.Yu. ,   Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, Kazan, Russian Federation, Shavaliev R.F. ,   Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, Kazan, Russian Federation
Published: April 2023

We report a rare case of acute unilateral renal papillary necrosis in a 45-year-old female patient with acute pyelonephritis, which led to recurrent gross hematuria. During the first episode of inpatient treatment, the patient started conservative therapy after the exclusion of the most common causes of hematuria. After 10 days, the patient was discharged and continued her treatment at an outpatient department. However, 6 days after the discharge from hospital, she developed bladder tamponade followed by profuse bleeding after 2 more days (when the patient was hospitalized for the second time). Emergency angiography with subsequent superselective catheterization of the inferior renal polar artery and embolization of the bleeding source with PVA embolization particles (foamed polyvinyl alcohol) stopped the bleeding. After a course of comprehensive symptomatic therapy, the patient was discharged for outpatient treatment. Follow-up examination after 1 month showed that her condition was satisfactory; there was no evidence of latent bleeding.
Reasons for rejection of transvaginal mesh implants in pelvic organ prolapse surgery
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Utigalieva E.B. , Snurnitsina O.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shpikina A.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Taratkin M.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Nikitin A.N. ,   L.A.Vorokhobov City Clinical Hospital No 67, Moscow Department of Health, Moscow, Russian Federation, Enikeev M.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Enikeev D.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   Department of Urology, Medical University of Vienna, Vienna, Austria
Published: April 2023

This article analyzes the reasons for refusal to use mesh implants in pelvic organ prolapse surgery (mesh technology), which has recently been widely discussed in the international community. Large-scale analytical reviews and results of randomized clinical trials comparing the effectiveness of standard surgical interventions (native tissue repair) and mesh technologies were described in detail, and the prospects for further development of the latter were outlined. The popularity of mesh technologies used to correct pelvic organ prolapse, which peaked in 2004–2010, led to the widespread and not always justified use of transvaginal mesh implants. The subsequent drastic decline in the use of mesh technology in urogynecology was due to several reasons: postoperative complications, poor experience of physicians, and the frequent involvement of mesh implant manufacturers in litigation.
Editorial JPI Vol 6 No 1 2023
Authors: Kunto Imbar
Published: May 2023

DAFTAR ISI                Volume 6, Nomor 1, Maret 2023.

Tapilouw, M. C. (2023). Inovasi Pembelajaran: Integrasi antara Perkuliahan Daring dan Praktikum Luring saat Adaptasi New Normal. Jurnal Pembelajaran Inovatif, 6(1), 01 - 06.

https://doi.org/10.21009/JPI.061.01

 

Dian Affan Hidayat. (2023). Pengembangan Media Pembelajaran Transmisi Continously Variable Transmission (CVT) Sepeda Motor Automatic Berbasis Video Pada Mata Kuliah Sepeda Motor Dan Motor Kecil. Jurnal Pembelajaran Inovatif, 6(1), 07 - 16. https://doi.org/10.21009/JPI.061.02

 

Putri Febrianti, V. (2023). Analisis Kesulitan Guru Biologi SMAN 2 Pandeglang dalam Mengimplementasikan Pembelajaran Terdiferensiasi. Jurnal Pembelajaran Inovatif, 6(1), 17 - 24. https://doi.org/10.21009/JPI.061.03

 

Jaya, D. J. (2023). Peningkatan Motivasi Belajar Siswa Menggunakan Metode Tutor Sebaya Pada Program Keahlian Teknik Konstruksi Dan Properti SMK Negeri 2 Yogyakarta . Jurnal Pembelajaran Inovatif, 6(1), 25 - 34. https://doi.org/10.21009/JPI.061.04

 

Eko Rudi Hartono, R. Y. (2023). Pengembangan Media Kartu Bergambar Elektronik Pada Kelas V Sekolah Dasar. Jurnal Pembelajaran Inovatif, 6(1), 35 - 42. https://doi.org/10.21009/JPI.061.05

 

Andinnari, S. R., Kustandi, C., & Chaeruman, U. A. (2023). Pengembangan Self-Directed Learning Online Course “Decision Making” untuk Karyawan PT. Smartfren Telecom, Tbk. Jurnal Pembelajaran Inovatif, 6(1), 43 - 49. https://doi.org/10.21009/JPI.061.06

 

Nurul Nabilah, Uwes Anis Chaeruman, & Diana Ariani. (2023). Pengembangan Learning Object untuk Mata Pelajaran Ekonomi. Jurnal Pembelajaran Inovatif, 6(1), 50 - 55. https://doi.org/10.21009/JPI.061.07

 

Novi Alifah, Y., Situmorang, R., & Suprayekti. (2023). Pengembangan Buku Ajar Cetak Pada Subtema Ayahku untuk Peserta Didik Kelas 2 Tunagrahita SLB Negeri 3 Jakarta . Jurnal Pembelajaran Inovatif, 6(1), 56 - 63. https://doi.org/10.21009/JPI.061.08
El potencial del nudge como herramienta para la elaboración de políticas públicas
Authors: Ramos Fernando
Published: May 2023

Desde la perspectiva de la economía del comportamiento, el nudge, como mecanismo psicológico, es una herramienta potencial en la elaboración de políticas públicas, ya que ha sido ampliamente reconocido por su éxito en intervenciones recientes debido a su bajo coste de implementación. En ese sentido, este artículo analizó el potencial uso del nudge en las políticas públicas ante determinadas situaciones. Para tal fin, se ha realizado la revisión sistemática de literatura sobre la economía del comportamiento. Los resultados permitieron identificar el potencial de uso del nudge en políticas públicas respecto a decisiones predeterminadas, protección ante compras no solicitadas y contratos de renovación automática. En conclusión, el uso del nudge en la elaboración de políticas públicas permitiría a los gobiernos que lo aplican asegurar la eficacia de sus intervenciones y mejorar el nivel de aprobación de los ciudadanos.
A practical approach to choosing formulae for economic index numbers
Authors: Wood John
Published: April 2023

Traditional axiomatic, economic and stochastic approaches to choosing a formula for economic index numbers are based on theoretical considerations, with little regard to whether they reflect the actual circumstances affecting the markets to which they relate. This paper presents an approach to index number formulation based on how markets operate and presents a general, parameter-based formula for price and quantity indices. Two variants of this general formula cater for the “substitution effect” in different ways and one of these variants provides a practical expression for an economic-theoretic index based on purchasers' revealed preferences. Another variant applies this approach to short-term inflation indices. A final variant provides a straightforward means of estimating purchasing power parities for spatial indices. The analysis also emphasizes the importance of using coherent price and quantity indices, whose products generate the corresponding value indices.
Integration of Fractal modeling and Correspondence Analysis Reconnaissance for Geochemically High-Potential Promising Areas, NE Iran
Authors: Hosseini Seyed Aliakbar , Khah Nasser Keshavarz Faraj , Kianoush Pooria , Afzal Peyman , Ebrahimabadi Arash , Shirinabadi Reza
Published: May 2023

Most geochemical and geostatistical analysis in mining exploration requires removing regional trends in order to obtain local anomalies. In this paper, stream sediment samples, which collected from Khusf area (NE Iran), was studied based on Concentration-Area (C-A) fractal model as well as correspondence analysis methods to find high-potential areas elements. Correspondence analysis with 170 samples through 20 elements concentration values in each sample was performed. According to correspondence analysis, among one or several elements in the study area, local anomalies were separated which the highest concentration relates to the variables Pb, As, and Cd elements. After the correspondence analysis, the best variogram for the Khusf area was studied. Elemental concentration maps was then produced through estimating the values using kriging method. Therefore, using the fractal method, between three statistical sets of elements, it was concluded that the third set showed the anomaly for Pb, As, and Cd elements with local anomaly values respectively determined as 55, 7.2, and 0.88 ppm. Although Cd element is not genetically related to same source of Pb and As, utilizing integrated approach, Cd anomalies has also been detected in the area as a promising element zone. Finally, it is suggested that this region has the possibility of Basic Metals occurrence and suggests further geophysical operations on a local identification scale.
Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination
Authors: Fukuhara Hideo , Yumoto Kohei , Sako Miyuki , Kajikawa Mizuho , Ose Toyoyuki , Kawamura Mihiro , Yoda Mei , Chen Surui , Ito Yuri , Takeda Shin , Mwaba Mwila , Wang Jiaqi , Hashiguchi Takao , Kamishikiryo Jun , Maita Nobuo , Kitatsuji Chihiro , Takeda Makoto , Kuroki Kimiko , Maenaka Katsumi
Published: April 2023

Canine distemper virus (CDV) belongs to morbillivirus, including measles virus (MeV) and rinderpest virus, which causes serious immunological and neurological disorders in carnivores, including dogs and rhesus monkeys, as recently reported, but their vaccines are highly effective. The attachment glycoprotein hemagglutinin (CDV-H) at the CDV surface utilizes signaling lymphocyte activation molecule (SLAM) and Nectin4 (also called poliovirus-receptor-like-4; PVRL4) as entry receptors. Although fusion models have been proposed, the molecular mechanism of morbillivirus fusion entry is poorly understood. Here, we determined the crystal structure of the globular head domain of CDV-H vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibits a highly tilted homodimeric form with a six-bladed β-propeller fold. While the predicted Nectin4 binding site is well-conserved with that of MeV-H, that of SLAM is similar but partially different, which is expected to contribute to host specificity. Five N-linked sugars covered a broad area of the CDV-H surface to expose receptor binding sites only, supporting the effective production of neutralizing antibodies. These features are common to MeV-H, although the glycosylation sites are completely different. Furthermore, real-time observation using high-speed atomic force microscopy revealed highly mobile features of the CDV-H dimeric head via the connector region. These results suggest that sugarshielded tilted-homodimeric structure and dynamic conformational changes are common characteristics of morbilliviruses and ensure effective fusion entry and vaccination.
Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression
Authors: Zhang Fan , Xu Yue , Lin Jiediao , Pan Hongchao , Giuliano Armando E. , Cui Xiaojiang , Cui Yukun
Published: May 2023

Purpose: Forkhead box C1 (FOXC1) may act as a therapeutic target for triple-negative breast cancer (TNBC) but without a comprehensive understanding of its regulations, especially at the upstream. L1 cell adhesion molecule (L1CAM) is a transmembrane glycoprotein that may involve in brain metastasis. Indicated by a positive correlation between FOXC1 and L1CAM transcripts, this study aims to further examine their relation in the process of TNBC.
Methods: FOXC1 and L1CAM transcripts were downloaded fromtwo public datasets, and their proteins were examined in four TNBC cell lines. FOXC1 and L1CAM were separately knocked down in BT549 cells; L1CAM was overexpressed in BT549-shFOXC1, MDA-MB-231, and HCC1937 cells. CCK-8, transwell and wound healing assays were conducted in these cells, so was immunohistochemical staining in tumors.
Results: L1CAM and FOXC1 transcripts were positively correlated in public datasets. BT549-shFOXC1 cells showed a decreased L1CAM expression both at the transcriptional and protein levels. Intriguingly, BT549-siL1CAM cells displayed decreased FOXC1 proteins, but exerted little effect on FOXC1 transcripts. Conversely, overexpression of L1CAM resulted in upregulation of FOXC1 protein without substantial change in FOXC1 mRNA, that consistently observedin BT549-shFOXC1, MDA-MB-231-L1CAM and HCC1937-L1CAM cells. Additionally, decreased or increased capacities of cell proliferation, migration, and invasion were seen along with down- or up-regulation of FOXC1 or L1CAM. Finally, a positive correlation between L1CAM and FOXC1 proteins was observed in human TNBC tumors.
Conclusion:FOXC1 and L1CAM display coregulation at the protein level but not mRNA level to positively affect cell proliferation, migration and invasion in TNBC.
Inequality and Redistribution: A Broader Approach Valuating Public Services with an Application to France
Authors: André Mathias , Germain Jean-Marc , Sicsic Michaël
Published: April 2023

Who benefits from public transfers in France after paying taxes? We answer this question through an extended approach of redistribution, allocating 100% of national income and transfers between various categories of individuals using new micro-founded methods to monetize in-kind transfers and collective public services. We find that 60% of households are net beneficiaries of extended redistribution. By contrast, the proportion is only one-third with the usual monetary approach, as important items such as public services or VAT are not accounted for. The impact of redistribution on attenuation of inequalities is two times larger than with the usual monetary approach, with a major role for health and education. An analysis over age groups highlights a “paradox of horizons”: 90% of individuals over the age of 60 receive more than they pay, mainly via retirement pensions and health, versus less than 50% for those under the age of 60. For individuals without a diploma, the income gap between people aged 50 to 64 and the young falls from 130% before transfers to 25% after transfers; and for individuals with a bachelor’s degree, from 150–50%. Other types of analysis, such as family, gender, geographic area or social class, confirm the importance of the extended approach to properly assessing redistribution.
Classification JEL: E01, D63, O57.
A finite element study: the quantitative correlation between the displacement of osteotomy end and metatarsalgia during forefoot loading pattern in percutaneous minimal invasion surgery of hallux valgus
Authors: Cao Xuhan , Bai Zixing , Sun Chengyi , Xiong Binglang , Wen Jianmin , Sun Weidong
Published: April 2023

Objective To investigate the quantitative correlation between the osteotomy end displacement and the occurrence of transfer metatarsalgia in percutaneous minimal invasion surgery of bunion in the forefoot loading pattern.Methods The simulation of the operation of minimally invasive treatment of hallux valgus using the established finite element model with the period of forefoot load mode facilitated the correction of the distal end of the first metatarsal head after osteotomy by steps of 0–6 mm from inside to outside and from top to bottom; each displacement distance was 2 mm. The stress data were collected and analyzed at the osteotomy end and under each metatarsal head in the gait cycle, the quantitative correlation between the vertical and horizontal displacement and between the stress changes under the first and second metatarsal heads was clarified. Then, the correlation between the pressure changes of the first and second metatarsal heads in the gait cycle and the occurrence of postoperative transfer metatarsalgia was analyzed, and accurate quantitative indicators of displacement during the operation were identified.Results The forefoot loading pattern of the gait cycle assessed in the finite element model before and after percutaneous minimal invasion surgery of hallux valgus showed that when the horizontal displacement is 4 mm, the correlation between the pressure x at the distal end of the osteotomy (under the first metatarsal) and the corresponding pressure y under the second metatarsal is negative, the R value is -0.894, and the quantitative correlation is y=-0.6504x + 0.5232 with increasing vertical displacement. When the vertical displacement is 4 mm, the stress under the first metatarsal increases with the increase in horizontal displacement. Conversely, the pressure under the second metatarsal decreases. Both have a high correlation with horizontal displacement, with R values of 0.981 and − 0.890. Also, in this interval, the pressure x at the distal end of the osteotomy (under the first metatarsal) has the highest correlation with the corresponding pressure y under the second metatarsal head, the R value is -0.830, and the quantitative correlation equation is y=-0.4528x + 0.4159.Conclusion When the distal end of the first metatarsal osteotomy is shifted outwards by 4 mm, and the metatarsal side is shifted by 4 mm through bone setting manipulation during operation, percutaneous minimal invasion surgery of hallux valgus can reduce or cure hallux valgus. This might elevate the metatarsal pain during forefoot loading and avoid transfer metatarsalgia after hallux valgus operation.
Barriers to Access Fistula Services: An Account of Fistula survivors and ambassadors in Mwanza, Tanzania
Authors: Mutayoba Rita K. , Ndjovu Anthony C. , Ndahami Clement G , Dhalla Magdalena M. , Kimbute Omari , Ngalesoni Frida N.
Published: April 2023

Background
Obstetric fistula is a leading cause of pregnancy-related disability and stigma for around one million women across developing countries. There are between 50,000 to 100,000 new fistula cases each year worldwide, with less than 15,000 cases treated annually(1). In Tanzania, around 3,000 new fistula cases develop every year, with an average of 1,300(2) cases treated annually. This study aimed at understanding the barriers women living with obstetric fistula in rural and urban settings face in accessing fistula treatment services in Tanzania.
Methods
This study used an explanatory sequential design that started with a quantitative study and then built on qualitative findings to understand the barriers women living with obstetric fistula in rural and urban settings face in accessing fistula treatment services in Tanzania. The multi-stage cluster sampling design was adopted to obtain the sample of 126 fistula survivors whereby the analysis used both quantitative and qualitative methods of data analysis; in quantitative analysis, the STATA version 14 was used whereby analysis was conducted on all 43 variables that were measured using the Likert scale. Qualitative information was audio recorded, transcribed, translated, and uploaded in Nvivo 10 for analysis.
Results
The study shows myths and misconceptions, stigma, low self-esteem, financial and transport challenges, fear and worries, and lack of social support and awareness of barriers hinder women in Tanzania to access timely appropriate fistula treatment services.
The study revealed fistula survivors believed having a fistula was either a curse or caused by diabolic means. Fistula survivors reported being treated as outcasts and felt worthless because of isolation, the bad smell from continual leakage of urine and/or faeces; felt unclean, were ashamed of the condition, felt not complete as persons and were mistreated by their husbands. These made them anxious and depressed thus they did not want to travel to hospitals where they can get treatment.
Conclusions
Current and future fistula programming in Tanzania should consider targeted sustainable and consistent awareness creation that would address myths and misconceptions and other barriers related to awareness.
Reducing student spending by using behavioural insights: the SAVINGS Trial informed by a qualitative study
Authors: Patel Krishane , Rotaru Kristian , Schmidtke Kelly , Judah Gaby , Melkonyan Tigran , Vlaev Ivo
Published: May 2023

Households are currently struggling to keep up financial obligations with limited funds held away in savings account, however, the impact of interventions, such as financial education have demonstrated mixed efficacy. This study examines how behavioural interventions can produce substantial outcomes when using a holistic perspective of behaviour and cognition. We recruit a representative sample to participate in ethnographic interviews which we used to build two interventions, a Goal-setting intervention and a Habit-based intervention. We evaluated these interventions against a control group in a 12-week randomised controlled trial. We collected transactional data, presenting both monetary consumption and account balance activity. The Goal-setting intervention demonstrated significant improvements in both outcome measures, with reductions in monetary consumption and account balance. The Habit-based intervention did not demonstrate any treatment effects. We demonstrate how behavioural interventions can provide cost-effective solutions to increase saving propensity using promoting financial goals and action planning.
Treatment of Vertebral Compression Fractures with preoperative Lumbar support pad reduction: 19 cases and a literature Review of Physically Assisted Therapy
Authors: He Wei , He Da , Liao Tao , Feng Jingyun , Liu Mingming , Zha Xiluobu
Published: April 2023

BackgroundVertebral Compression Fractures and dislocation is usually treated by posterior open reduction nail or internal fixation system, but the high altitude lumbar surgery carries great risks. When the collapse of the vertebra fails to return to the normal height, kyphosis will occur in the later stage of the spine. For the patients with thoracolumbar vertebral compression fracture with pyramidal collapse, preoperative reduction of lumbar support pad was adopted, and good clinical results were obtained.Case presentation:According to the strict screening criteria, 19 patients with thoracolumbar compressibility fracture who will be treated in our hospital in 2021 were selected. All the selected patients were confirmed by imaging examination and the cone front height of compression fracture was measured before surgery. All patients received preoperative reduction treatment with lumbar support pads, and were reexamined after the treatment. The results showed that all patients had significant recovery in their lumbar spine, with VAS scores and activity function scores significantly superior to those before the treatment (p < 0.05). The height between vertebrae in all patients returned to the normal range, with 67.3% of patients having the best pyramidal recovery.Clinical discussion:The plateau has high altitude, low atmospheric pressure, and low oxygen content. It is extremely difficult to perform surgery on thoracic and lumbar vertebral compression fractures at high altitude. Preoperative adjuvant treatment is usually required to alleviate the condition, and then the patient is transferred to a low altitude area for surgery. In this study, lumbar support pads were used as an adjunct treatment to significantly improve the lumbar spine.ConclusionPreoperative reduction of lumbar support pad can effectively relieve the pain of patients with thoracolumbar compressibility fracture, effectively restore the height of compressed vertebral body before surgery, and effectively improve the patients' limited mobility. This treatment method is worth promoting in plateau medical institutions.
The gestational weight gain trajectories of full-term singleton pregnant women for different neonatal birth weight outcomes in Zhongshan, China: a multi-center retrospective longitudinal follow-up study
Authors: Li Bing , chen Ang
Published: April 2023

Background Low or excess gestational weight gain (GWG) is associated with higher risk of adverse maternal and infant outcomes, and the GWG charts were different in four pre-pregnancy BMI categories, but the GWG trajectories based on different pregnant outcomes were seldom established to date.Objectives To establish a maternal GWG trajectory for each neonatal birth weight category by pre-pregnancy BMI, and analyse their associations.Methods A retrospective longitudinal follow-up study was conducted base on the real-word electronic healthcare record of prenatal visit and delivery in 28 hospitals, which included 319,926 pregnant women between January 2017 and December 2020 in Zhongshan, China. The means and percentiles of GWG by gestational week (GW) for each neonatal birth weight category were calculated and fitted by GAMLSS, and were used to establish GWG trajectories respectively.Results There were 100,691 and 136,342 full-term singleton pregnancies in final two cohorts respectively. After 15th GW to 40th GW, low birth weight (LBW) or small for gestational age (SGA) had a lower level and macrosomia or large for gestational age (LGA) had a higher level of mean GWG comparing with normal birth weight (NBW) or appropriate gestational age (AGA) (P < 0.05) at each GW. The mean and percentile charts of GWG showed that the GWG trajectories were lower in LBW/SGA and higher in macrosomia/LGA than in NBW/AGA.Conclusions Neonatal birth weight outcomes are associated with the distinctive maternal GWG trajectories, and neonatal health outcomes depend on sustenance of an appropriate GWG trajectory.
Identification of PCB Congeners and their Thresholds associated with Diabetes using Decision Tree Analysis
Authors: Lan Tuo , Liu Buyun , Bao Wei , Thorne Peter S.
Published: May 2023

Few studies have investigated the potential combined effects of multiple PCB congeners on diabetes. To address this gap, we used data from 1244 adults in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. We used 1) classification trees to identify serum PCB congeners and their thresholds associated with diabetes; and 2) logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of diabetes with combined PCB congeners. Of the 40 PCB congeners examined, PCB 126 has the strongest association with diabetes. The adjusted OR of diabetes comparing PCB 126 > 0.025 to ≤ 0.025 ng/g was 2.14 (95% CI 1.30–3.53). In the subpopulation with PCB 126 > 0.025 ng/g, a lower PCB 101 concentration was associated with an increased risk of diabetes (comparing PCB 101 < 0.72 to ≥ 0.72 ng/g, OR = 3.3, 95% CI: 1.27–8.55). In the subpopulation with PCB 126 > 0.025&PCB 101 < 0.72 ng/g, a higher PCB 49 concentration was associated with an increased risk of diabetes (comparing PCB 49 > 0.65 to ≤ 0.65 ng/g, OR = 2.79, 95% CI: 1.06–7.35). This nationally representative study provided new insights into the combined associations of PCBs with diabetes.
Variable-Order Conformable Fractional Derivatives using 2-stage Runge-Kutta and Euler Methods
Authors: Mishra S. R. , Mohapatra S.N. , Jena P.
Published: April 2023

The present investigation is intended to the implementation of new numerical approaches for the variable-order conformable fractional derivatives that override the fact of earlier constant order fractional derivatives. The generalized conformable variable-order Taylor’s theorem is deployed to extract two new techniques such as conformable variable order 2-stage Runge-Kutta and conformable variable order Euler methods. Further, these numerical techniques are employed by considering various fractional variables as well as constant order derivatives. However, the main attraction of these two methodologies is also applicable to fractional financial model and comparison of these methodologies with classical derivatives, and the numerical results are appended in tabular form as well as graphically.
The Epidemiology of Types of Ocular Trauma in A Tertiary Center in North of Iran
Authors: Alizadeh Yousef , Sardabchahi Ghazaleh Mohammadi Manesh , Medghalchi Abdolreza , Behboudi Hassan , Soltani-Moghadam Reza , Akbari Mitra , Azaripour Ebrahim , Poursayed Seyedeh Zahra , Nabavi seyed Amin , Kianmehr Shila , Alizadeh halleh , Dourandeesh Maryam Dourandeesh , Leyli Ehsan Kazemnejad , Pourdeilami Narges
Published: May 2023

PurposeTo investigate the epidemiology of types of ocular trauma in a tertiary center in north of Iran.MethodsThis cross-sectional study was carried out on 476 patients with ocular trauma referred to emergency eye department of Amir-Almomenin Hospital in 2021. Personal information and types of traumas collected by medical records and a designed questionary. Data were collected and analyzed using IBM SPSS 26. Descriptive statistics were used to determine the frequency and distribution of traumas.ResultsThe most vulnerable groups were 31–40 years (28.8%) and mean age of 41.5 ± 17.4. Most of the injuries occurred at home (57.1%) and few of them used eyewear (5.3%). Patients were mostly lived in city. Closed globe injuries were the prominent types of traumas at about (96%) and Open close injuries were at a low rate (4%).ConclusionOcular Trauma is a common cause of trauma in north of Iran. Closed globe injuries were the most common types of traumas occurred between the age of 30–40 and male were most commonly susceptible
A Nude Mutant Derived from Five Decades-Old Rat Colony with an Immuno-potent Character - A Potential Model for Non-Communicable Diseases.
Authors: Satyavani M. , Patil Pradeep B. , Naik R. Ravindar , Srin M. , Qadri SSYH
Published: April 2023

Background: A spontaneous mutant rat with a hairless phenotype and an intact thymus was discovered in a long-standing SD/NIN rat colony at a national animal resource facility.
Objective: We conducted extensive phenotypic and biochemical analyses on this mutant strain to determine its suitability as a preclinical model for immunocompetent testing in non-communicable disease research.
Methodology: To accomplish this objective, we subjected the mutant rats to strict and frequent phenotypic and genetic surveillance. We assessed their food intake, body weight, blood cell profile, clinical chemistry, adipose tissue deposition, and bone mineral density using TOBEC and DXA analysis.
Results: Initially, only two hairless mutant rats, a male and a female, were born from a single dam in the SD/NIN rat strain. However, the results indicates that the mutant colony propagated from these unique pups displayed distinct phenotypic features and exhibited differences in feeding behaviour, weight gain, and clinical biochemistry. The food conversion rate (FCR) was significantly higher in nude females (2.8-fold) while 26% lower in nude males. Both sexes of nude rats had significantly higher triglycerides and lower glucose levels in females. However, glucose levels did not change in male nude rats. Furthermore, nude female and male rats had significantly lower fat (TOBEC) and bone mineral content (DXA). Nonetheless, bone mineral density was only slightly lower (7-8%) compared to the heterozygous groups.
Conclusion: These findings indicate that the spontaneous mutant rat has the potential to serve as an immuno-potent and modulatory testing system in PK/PD and toxicology, which can be further explored for therapeutic drug discovery.
Neural network-aided milk somatic cell count gain prediction
Authors: Nagy Sára Ágnes , Csabai István , Varga Tamás , Póth-Szebenyi Bettina , Gábor György , Solymosi Norbert
Published: April 2023

Sub-clinical mastitis (SM) is the most economically damaging yet often visually undetectable disease of dairy cows. Early detection and treatment can reduce the loss caused by the disease, thus, the continuous improvement of SM diagnostic methods is necessary. Albeit, the somatic cell count (SCC) of milk is commonly measured for diagnostic purposes, its direct determination is not widely used in everyday practice. The primary objective of our work was to investigate whether the predictive value of SM diagnostics can be improved by training artificial neural networks (ANNs) on data generated using common milking machines. The best ANN classifier had a sensitivity of 0.54 and a specificity of 0.77, which is comparable to the performance of several California Mastitis Tests (CMT) in the literature. Combining two diagnostic tests, ANN and CMT, we concluded that the positive predictive value could be up to 50% higher than the value provided by the individual CMT. While the implementation of CMT is a labor-intensive process, in milking parlors where milk or milk yield data can be measured automatically, similar to our work, SCC-gain predictions for all individuals could be obtained on a daily basis.
Design of polymeric thin films with nanovolcanoes for trapping hydroxyapatite nanoparticles to promote or inhibit cell proliferation
Authors: Łojkowski Maciej , Walejewska Ewa , Sosnowska Malwina , Opalińska Agnieszka , Grubczak Kamil , Jaworski Sławomir , Moniuszko Marcin , Swieszkowski Wojciech
Published: May 2023

Arrays of nanoscale cavities in the form of nanovolcanoes can act as traps for nanoparticles to obtain surfaces with the desired functionality. The nanoparticle trapping strategy is based on generating negative pressure inside the nanocavities and aspiration of nanoparticles from the suspension. A new approach has been proposed to prepare polymeric nanocavities and tune their geometry to increase trapping efficiency. The strategy uses microphase separation in a polymer blend and tuning the shape of polymer islands to use them as molds for nanovolcanoes by tuning the molecular weight distribution of the island phase. Tuning the silhouette of the nanovolcanoes made it possible to find a geometry that allows air storage. Hydroxyapatite nanoparticles were entrapped in the nanovolcanoes to show that cells will proliferate in the presence of nanovolcanoes with hydroxyapatite, while nanovolcanoes without hydroxyapatite will block proliferation.
Tecnologias digitais e interdisciplinaridade no ensino de fisiologia humana
Authors: Lima Luciana de , Cardoso da Rocha Maria Ariane , Loureiro Robson Carlos
Published: April 2023

O objetivo é analisar como as Tecnologias Digitais da Informação e Comunicação (TDICs) contribuem para a compreensão de estudantes do Ensino Médio de escola pública sobre Fisiologia Humana, a partir de aulas interdisciplinares de Biologia e Educação Física. Diante do problema da fragmentação dos conhecimentos e da aplicação de metodologias expositivas no processo de ensino do conteúdo de Fisiologia Humana, desenvolveu-se a pesquisa qualitativa exploratória, com a participação de 17 estudantes, durante os meses de agosto a outubro de 2019. A pesquisa se subdividiu em três fases: planejamento, coleta e análise de dados. As coletas foram realizadas a partir de questionário avaliativo, produção de vídeo caracterizando um Material Autoral Digital Educacional (Made) e aplicação de questionário a posteriori. A análise de dados foi realizada de forma interpretativa, com ênfase em dois focos: estabelecimento de relações entre os conceitos de pressão arterial e fisiologia do exercício, e facilidades e dificuldades no estabelecimento entre essas relações. O trabalho demonstrou a presença de acréscimos conceituais dos estudantes: compreensão do sistema circulatório humano, papel da pressão arterial no organismo e atuação de hormônios nas respostas aos estímulos externos. A construção do próprio saber demonstrou ser um importante caminho para tornar a aprendizagem mais significativa do ponto de vista ausubeliano.
Unmanned aerial vehicles for planning rooftop rainwater harvesting systems: a case study from Gurgaon, India
Authors: Puppala Harish , Peddinti Pranav R. T. , Kim Byungmin , Arora Manoj Kumar
Published: April 2023

Rooftop rainwater harvesting systems (RRWHS) effectively provide water access by storing precipitated water. The amount of water harvestable using these systems is proportional to the availability of rooftop areas in the region. The use of satellite imagery has gained traction in recent times considering the challenges in conducting a manual survey to determine the rooftop area. However, the limitations on spatial resolution impaired stakeholders from conducting similar assessments in areas with small residential units. In this regard, the use of unmanned aerial vehicles (UAVs) providing high-resolution spatial imagery for the delineation of rooftops of all scales has become popular. The present study is an attempt to utilize UAV-generated orthomosaics to estimate the harvestable quantity of rainwater for setting up an RRWHS. A study area in the Gurgaon district, India, is selected, and the steps involved in estimating the quantity of water harvestable using UAVs are demonstrated. In addition to these computations, a suitable site for constructing the storage unit is identified with the aid of a weighted overlay technique implemented using a Geographic Information System. The results from the study show that nearly 11,229 m3 of water can be harvested per year in the study site using the RRWHS.
Evaluation on real-time self-organization algorithm of forest cultivation, tea planting and tea processing for sustainable ecosystem management of agricultural water resources
Authors: Wang Zhenhong , Zhang Liyong , Song Minfeng , Luobu Sangjie , Jiu Mei , Dan Zhen , Peng Hong
Published: April 2023

Agricultural water resources are water resources that can be used for agricultural production, including surface water, groundwater and soil water. The sustainable use of water resources is of great significance to agriculture and rural economy. In the context of climate change and the increasing crisis of water resources, how to effectively use forest resources and other natural resources to achieve sustainable management of agricultural water ecosystems has become an increasingly urgent issue. Therefore, this paper proposed a real-time self-organization algorithm for forest cultivation, tea planting and tea processing for sustainable ecosystem management of agricultural water resources. This paper first described the sustainable ecosystem of agricultural water resources, carried out optimization analysis on tea planting and processing technology, using the genetic optimization algorithm based on decision tree and then carried out an experimental analysis on a tea garden. It can be seen from the data that the average monthly temperature of the tea garden cultivated by the algorithm in this paper was between 13.4 and 20.5 °C and the average annual temperature was 16.16 °C. However, the average monthly temperature of the traditional cultivation method was between 11.5 and 16.8 °C and the average annual temperature was 13.64 °C.