bluuebunny/crossref_metadata_2025 huggingface dataset:
Het ‘Huis met de twee torens’ in de Veldstraat.
Authors: Vergeynst Dirk
Published: June 2022

Al heel vroeg, in de twaalfde -dertiende eeuw, was Gent vermaard om zijn hoge en grote natuurstenen woningen. In dit artikel wordt gepoogd de beschikbare literatuur over dit huis in de Veldstraat te koppelen aan archivalische en archeologische gegevens en dit te projecteren op de huidige toestand.
D’azenten goan opzije oan ze den tram zien rije
Authors: Dousselare Hans , Devriese Luc , Gysseling Sonja
Published: June 2022

Enkele liefdevol bewaarde papiertjes bewaard in het DSMG met verhalen over de tram in Gent.
Kraakhuis in de Gentse Bijloke: Pesthuis.
Authors: Devriese Luc , Maréchal Griet
Published: June 2022

De naam Kraakhuis duikt op in verband met de opvang van lijders aan builenpest. We komen tot de conclusie dat Kraakhuis zeer waar schijnlijk de volkse benaming was voor Pesthuis.
Pareltjes uit het Begijnhof
Authors: Dousselare Hans
Published: June 2022

Sirooplepeltjes tegen kinderverlamming.
Marie-Jeanne Schellinckx, een Gentse Grognarde
Authors: Vermeirsch Eric
Published: June 2022

Kenners van de Napoleon-literatuur weten natuur lijk wat een Grognard is, maar tot mijn verbazing kon ik lezen dat er ook sprake was van een Grognarde, en wel een Gentse.
Gent en de Lage Landen in 1517. Reisverslag van kanunnik Antonio de Beatis,
Authors: De Vleeschouwer Herbert
Published: June 2022

In 1517-1518, hield kanunnik Antonio de Beatis. alle observaties van zijn reis bij en bundelde hij ze, Sinds de herontdekking in 1893 in Napels werd deze tekst in het Duits vertaald, in het Frans en in het Engels. In deze vertaling naar het Nederlands wordt enkel aandacht besteed aan het bezoek aan Gent, en de waargenomen gebruiken in Vlaanderen.
Ethelinde en Engelran. Tragische liefde tijdens de Gentse opstand (1381): een romantische fantasie.
Authors: Delepierre Octave
Published: June 2022

In 1845 publiceerde Bruggeling Octave Delepierre, op dat moment Belgisch consul in Engeland, in het Engels een volbloed romantisch verhaal over de liefde van een jong Gents koppel, Ethelinde en Engelran. Dat zag zijn droom gedwarsboomd door de sinistere liefdesrivaal Gerard de Moor, eveneens Gentenaar. De dramatische ontknoping komt er in Brugge waar de Gentenaars na hun overwinning op het Beverhoutveld (1382) de verslagen Vlaamse graaf Lodewijk van Male en zijn Brugse bondgenoten achterna zaten. De edelmoedige Engelran en zijn lieflijke Ethelinde worden beiden doodgestoken door de gruwelijke rivaal.
De poort aan de Hoofdbrug: een vergeten stadspoort.
Authors: Devriese Luc
Published: June 2022

De Burgstraat is een oude en al eeuwenlang zeer belangrijke straat. Ook
al zwijgen zelfs de meest volledige beschrijvingen van de Gentse stadsverdediging
(1200-1300) erover in alle talen, er was wel degelijk een stadspoort die de vrije toegang vanuit ‘de buiten’ via die straat belette: de poort aan de Hoofdbrug over de Lieve. Het onbetwistbare bestaan van deze
poort tot 1370 roept moeilijk te beantwoorden vragen op, vooral in verband met de toegang tot het grafelijk domein bij het Gravensteen.
Treintoerisme in 1838. Eerste treingids voor België: Gent - Zuid als belangrijk treinstation.
Authors: De Vleeschouwer Herbert
Published: June 2022

‘Le guide du voyageur en Belgique sur le parcours du chemin de fer de l’état’ van Auguste Gobert verscheen in 1838, één jaar voordat de allereerste treingids met uurtabellen in Engeland gepubliceerd werd. Op basis van wat daarin te lezen staat, wordt een visie gegeven van onze vroege spoorweggeschiedenis. Opvallend is de plaats die Gent, toen tweede stad van het jonge België, daarin toebedeeld krijgt.
Gent en handeldrijvend Vlaanderen in 1495 Gezien door geograaf Hiëronymus Münzer Reisverslag (uittreksel)
Authors: De Vleeschouwer Herbert
Published: June 2022

Een uittreksel uit een tekst van de humanistische auteur en geograaf Hiëronimus Münzer. Hij heeft oog voor materiële en economische factoren zoals bodemgesteldheid, waterlopen en handelsbetrekkingen. Voor de politieke houding van Gent en Brugge in conflict met de autoritaire Maximiliaan van Oostenrijk, kan hij geen begrip opbrengen. Hij is van mening dat deze steden door hun weelde voortvarend worden en zichzelf in de vernieling drijven.
Grafmonument Jan Samijn door Bentos (Achilles De Martelaere), Westerbegraafplaats.
Authors: Bourgeois Jean
Published: June 2022

Een van de meest opvallende grafmonumenten op de Westerbegraafplaats is ongetwijfeld dat van Jan Samijn (1869-1933). Het werd ontworpen en gerealiseerd in 1934 door Achilles De Maertelaere (Bentos, Gent 1882-1964). Jan Samijn was een sterk geapprecieerde vakbondsleider die de rechten van de textielarbeiders in Gent verdedigde.
Spaans kasteel in Gent: defensief ontoereikend vanaf de zeventiende eeuw
Authors: Hanson Marc
Published: June 2022

In de zeventiende eeuw waren de beproefde tactieken uit de late middeleeuwen niet meer opgewassen tegen modern uitgeruste en beter opgeleide troepen van steeds grotere omvang. Vooral door de almaar verder dragende en preciezere artillerie kregen zelfs fortificaties naar verbeterd Italiaans model zoals het in de loop der jaren defensief aangepaste Spaans Kasteel het steeds harder te verduren.
Graficus - Bouwkundige Lieven Cruyl. Deel 1. Leven, betekenis en Gentse projecten (1662-1684)
Authors: Devriese Luc
Published: June 2022

In dit eerste deel van twee wordt een korte beschrijving gegeven van leven en werk van Lieven Cruyl, graficus van internationaal formaat, geboren in Gent (1634). Hij verwierf vooral bekendheid door zijn stadsgezichten
(vedute) van de Romeinse monumenten in zijn tijd. Ander werk is te situeren in en rond Parijs. In Gent tekende hij ambitieuze plannen voor de voltooiing van bestaande torens. Het enige bouwontwerp dat effectief gerealiseerd werd, was een houten Belfortspits-klokkenhuis in gotische stijl, vrij goed gelijkend op de huidige stenen versie uitgewerkt door Valentin Vaerwyck.
Houdin, hypotheekbewaarder, drukker en uitgever in Gent
Authors: De Latte Guido
Published: June 2022

De belangrijke Gentse uitgever Julien Nicolas Houdin, van Franse origine, begon zijn carrière als hypotheekbewaarder in dienst van het revolutionaire bewind. Vermoedelijk dankzij goede relaties in de politieke en intellectuele wereld van toen, slaagde hij erin zowel onder Frans als onder Hollands bestuur een indrukwekkend aantal uitgaven en drukken van boeken en periodieken te realiseren in Gent.
Frans Pilsen, beeldend kunstenaar en fabriqueur van papier
Authors: Mattens Danny
Published: June 2022

Frans Pilsen (Gent, 1700-1784) was een veelzijdige, ondernemende en ongetwijfeld drukbezette man. Opgeleid in de schildertechniek en de grafiek, legde hij vooral de nadruk op het graveren. Pilsen combineerde deze
kunstzinnige activiteiten met het opstarten en draaiende houden van een voor die tijd vrij grootschalig proto-industrieel initiatief: de papiermolens van Ekkergem aan Einde Were en de Overzet.
Krakers in 1707? Jacobus Abat in geschil met Jan Baptiste de Wagheneere over de ontruiming van een huis.
Authors: Mattens Danny
Published: June 2022

Jacobus Abat en Jan Baptiste de Wagheneere vochten in 1707 een geschil over een woningeigendom dat uiteindelijk door de schepenen van de Keure van de stad Gent werd beslecht. Hoewel het hier niet echt om ‘krakers’ gaat zoals we nu kennen, geeft de korte beschrijving van dit conflict toch aan dat eigendommen van huizen en gronden driehonderd jaar geleden terdege vastlagen en dat schriftelijke eigendomsbewijzen bij conflicten ook toen erg nuttig waren. Een kadaster van eigendommen zoals dat nu ongeveer tweehonderd jaar functioneert, bestond nog niet.
Cies, voiture chauffée
Authors: Andelhof Emiel
Published: June 2022

Licht bewerkte versie van een stukje uit ‘Galerij van Ghentsche Typen’ van Emiel Andelhof, 1942, een uitgave van KBOV, Kraanlei 65, Gent, toen ‘Bond der Oost-Vlaamsche Folkloristen', ter gelegenheid van de zeventigste verjaardag van de auteur, geboren (1870) in de Sint-Lievenspoortstraat.
Klauwkapkar voor runderen: ontworpen door practicus Ferdinand Pluym (1959)
Authors: Devriese L. , Van Aert M.
Published: June 2022

In 1959 vroeg practicus Ferdinand Pluym in België een brevet aan voor een mobiel toestel voor de immobilisatie van runderen bij hoefverzorging en operaties. Gemonteerd op lichte autowielen en als aanhangwagentje mee gevoerd met de praktijkwagen werd dit een handig en uiterst nuttig middel om aan hoefverzorging te doen op de verspreide bedrijven. Algauw werden dergelijke ‘klauwkapkarren’ ook gebruikt door gespecialiseerde hoefverzorgers bij runderen.
Rural Geography Revisited: Op zoek naar de geografie in het platteland
Authors: Haartsen Tialda
Published: June 2022

Oratie uitgesproken door prof.dr. Tialda Haartsen op 22 april 2022 bij de aanvaarding van het ambt van hoogleraar Rurale Geografie aan de Faculteit Ruimtelijke Wetenschappen Rijksuniversiteit Groningen. In haar inaugurele rede gaat Haartsen in op hoe beleid beter kan worden afgestemd op de behoeften en realiteiten van het platteland. Het Europese platteland maakt zich op voor een groot aantal ontwikkelingen, zoals de energietransitie, transities in de landbouw, klimaatverandering, toenemende ruimtelijke ongelijkheid, de geopolitieke en economische gevolgen van de oorlog in Oekraïne, en dit alles in een context van een vergrijzende en afnemende bevolking. Deze transities zullen de hedendaagse verhoudingen tussen globaal en lokaal, tussen centrum en periferie en tussen stad en platteland behoorlijk op de kop gaan zetten. Met alle gevolgen van dien voor de ruimtelijke inrichting van het platteland.
Identificación molecular de los tipos de compatibilidad en poblaciones de Podosphaera xanthii (Erysiphaceae) infectando cucurbitáceas en Veracruz, México
Authors: González Dolores , Gregorio-Cipriano Rosario
Published: June 2022

Antecedentes y Objetivos: La fase sexual de Podosphaera xanthii, reconocida por la presencia de casmotecios, se ha observado esporádicamente. La ausencia de uno de los tipos de apareamiento o de compatibilidad (TC) MAT1-1 o MAT1-2, o una proporción desigual, es la explicación más probable. En este trabajo se identificaron y cuantificaron los TC presentes en poblaciones de P. xanthii infectando cucurbitáceas en diversas localidades de Veracruz.

Métodos: Se hicieron preparaciones microscópicas para identificar y corroborar la presencia de casmotecios. Se extrajo ADN de 114 muestras recolectadas en diferentes localidades y especies hospedantes. La identificación de los TC se realizó mediante una PCR múltiple, usando oligonucleótidos específicos para los genes MAT1-1-1 (167 pb) y MAT1-2-1(228 pb) de P. xanthii. La amplificación de los genes se verificó mediante electroforesis. Las frecuencias de TC por campo de cultivo, estación del año, año de colecta y hospedante se analizaron usando χ2.

Resultados clave: Ningún espécimen presentó casmotecios. Sesenta y cuatro muestras amplificaron ambos idiomorfos, 34 sólo MAT1-2-1 y 16 únicamente MAT1-1-1. No hubo diferencias en la proporción de ambos TC en un solo campo de cultivo, estación del año o año de recolección. En contraste, la proporción de ambos TC por hospedante sí tuvo diferencias (χ2 = 16.856, p = 0.009). Esta relación sólo fue significativa en Cucurbita moschata con una mayor proporción de MAT1-1-1 (p = 0.002) y en C. okeechobeensis subsp. martinezii con una mayor proporción de MAT1-2-1 (p = 0.01).

Conclusiones: Ambos TC necesarios para la reproducción sexual de P. xanthii se encuentran en una proporción cercana al 1:1 en la mayoría de las poblaciones de Veracruz. Por lo tanto, la ausencia de casmotecios no parece estar relacionada con la falta de uno de los TC sino a diferentes factores que necesitan ser evaluados.
COMPARATIVE ANALYSIS OF GLIMEPIRIDE AND GLICLAZIDEMR USE IN TYPE 2 DIABETES MELLITUS TREATMENT
Authors: Kravchun N. A. , Khyzhnyak Oksana
Published: June 2022

Results of the hypoglycemic therapeutic efficiency of Gliclazide and Glimepiride in patients with type 2 diabetes mellitus are represented in the open prospective study. Daily dose of GliclazideMR was 90 mg, and Glimepiride — 4 mg. It is evident that third-generation sulfonylurea — Glimepiride has more protective cardiovascular effects because it significantly decreases microalbumiurea. Moreover, it significantly improves postprandial and basal glycemia, and the HDLP cholesterol level in patients with 5-year DM2 history. As an anti-diabetic drug Glimepiride has some advantages with regard to a high risk of microvascular complications when the disease is in progress.
AGE OF DIABETES MELLITUS MANIFESTATION. REGRESSION ANALYSIS
Authors: Atramentova L. A. , Barbul O. P.
Published: June 2022

First-degree relatives of a diabetic patient run a high risk of being afflicted with diabetes mellitus. For genetic estimation and evaluation of a possible age of diabetes mellitus manifestation in a patient’s relatives it is worthwhile using a correlation coefficient and a regression equation, which were worked out in the present study.
THE PECULIAR FEATURES ACTION OF CRYOPRESERVED EMBRYOFETAL COMPLEX BIOPREPARATIONS ON THE THYROID FUNCTIONAL ACTIVITY OF RABBITS WITH EXPERIMENTAL HYPOTHYROIDISM
Authors: Malova Nataliya , Komarova Irina , Yurchenko T. N. , Sergienko L. Y. , Sirotenko Larisa , Brechka Nataliia , Taranova K. S.
Published: June 2022

The influence of the cryopreserved fetal thymus biopreparation was correlated with the suspended fetal tissues action on the thyroid functional activity of rabbits with the suppressed thyroid function (merkazolil experimental hypothyroidism). Profound thyroid-stimulating effects of the both biopreparations have been revealed. Their ability to have an effect upon the hypothyroid function was detected to decrease the blockaged action of thyrostatic substances after their application having been resulted in the thyroid microstructure restitution. The influence of the suspended fetal tissues biopreparation was noted to be more effective about renewing the thyroid parenchyma functional activity.
PHENOTYPE PATTERN OF SINGLE NUCLEOTIDE POLYMORPHISM OF PARAOXONASE GENE (Q192RPON1) IN TYPE 2 DIABETIC PATIENTS
Authors: Gorshunska Maryana
Published: June 2022

We studied the input of genetic and metabolic factors (PON1 gene polymorphism — Q192RPON1 genotype and glucolypotoxicity, respectively) to formation of enzyme functional characteristics in Type 2 diabetic patients (n = 31). Phenotyping of 79 blood samples was done by using PON1 rates of hydrolysis is of paraoxon (POase activity) and diazoxon (DZOase activity). POase activity was generally lower in diabetics than in control subjects. It was also found that against the background of conservation a determinant role of Q192RPON1 genotype for its phenotype the modulating impact of metabolic disturbances (a namely significant decrease in POase activity) was verified only in patients with QR genotype, which have been characterized significant more higher POase activity vs QQ genotype.On the other hand, there were diagnosed more pronounced hormonal-metabolic disturbances related to insulin resistance and oxidative stress in QQ homozygotes vs QR heterozygotes (increase in circulating leptin levels and decrease in erythocyte gluthathionperoxidase concentrations). We also confirmed that diazoxonase / paraoxonase activities index provides PON1 phenotype and genotype and an accurate inference of PON1 genotype. Both are important parameters for determining an individual’s PON1 status in Ukrainian Type 2 diabetes population.
A CASE OF ACTIVE ACROMEGALIA COMPLICATED KIDNEY CANCER WITH ADNASTAL METASTASIS
Authors: Mikityuk Myroslava , Khizhnyak Oksana , Tyazhelova O. V. , Alekseeva I. І. , Kravchenko G. G.
Published: June 2022

Insulin-like growth factor-1 (IRF-1) plays an important role in the development of malignant neoplasms such as colorectal cancer, breast and lung cancer. Several clinical and experimental studies have demonstrated the effect of high levels of IRF-1 in the blood and the expression of its receptors in tissues on their malignancy. Somatotropic hormone of the pituitary gland (STH) is involved in oncogenesis not only indirectly, by increasing the production of IRF-1 by the liver, but also directly but, realizing its effects through STG receptors (rSTG), are expressed in various tumors
THE INFLUENCE OF HYPOPINEALISM ON FEATURES OF THE LIVER STRUCTURE AND DEVELOPMENT of ATEROGENIC DISLIPIDEMIA
Authors: Kuzminova I. A. , Kondakov I. K. , Galchinskay V. Yu. , Bondarenko L. A.
Published: June 2022

The paper offers the results of research in matured male rabbits by keeping them in conditions of round-the-clock illumination during 5 months and / or on cholesterol diet. Long-time suppression of the melatonin-producing function of the pineal gland by means of light causes pronounced changes in the lipid metabolism and the use of light exposure to the animals against the background of the cholesterol diet significantly enhances and accelerates the development of biochemical changes in the lipid metabolism and causes the morphofunctional changes in the liver, leading in its gradually destruction.
ENDOCRINE FUNCTION AND SOME METABOLIC PARAMETERS OF CASTRATED ANIMALS WITH TRANSPLANTATED OVARIAN TISSUE
Authors: Tischenko Ju. O. , Kiroshka V. V. , Bondarenko T. P.
Published: June 2022

In this study we investigated the dynamics of the endocrine function and some metabolic indices of castrated animals with auto- and allotransplantation of matured ovarian tissue and neonatal ovaries for a long observation period. Auto- and allotransplantations of matured ovarian tissue were found to lead to the restoration of the sex hormone level and metabolic parameters in castrated recipient animals for a long period, whereas in the transplantation of neonatal ovaries the hormone substitution effect is observed only at the early stages after transplantation.
DISTINCTIVE FEATURES OF FEEDING BEHAVIOUR AND THE FAT TISSUE FORMATION IN THE FEMALE RAT OFFSPRING OF MOTHERS STRESSED IN PREGNANCY
Authors: Sergienko L. Yu. , Perets O. V. , Kartavtseva O. V. , Bondarenko T. V.
Published: June 2022

The study was aimed at investigation of distinctive features of feeding behaviour and fat tissue formation in the reproductive aged female rats whose mothers were stressed in the first tirm of the pregnancy. It has been shown that adult stressed offspring had higher body mass and the visceral fat tissue. The influence of stress factors in postnatal life resulted in the increased body mass and mesenteric fat weight along with the decreased food intake. It has been proposed that the neuroendocrine system change in the offspring of stressed mothers led to the change of the energy metabolism and the development of obesity
THE PROFOUND EFFECT OF DEXAMETHASONE ON SOME PARAMETERS OF THE FUNCTIONAL STATE OF SKELETAL MUSCLE OF WHITE RATS
Authors: Trush V. V.
Published: June 2022

In experiments on white rats it has been shown, that the single parenteral injections of dexamethasonein a dose of 2 mg/kg neither after 1 hour nor after 1 day following introduction have not influenced upon the power characteristics of the forward tibial muscle but promoted to the improvement of its speed characteristics and to a decrease in maximal steady capacity. The ability of the muscle to retain the amplitude of its contractions at the submaximal level following 1 hour after introduction of dexamethasone increased, while on the next day after introduction of the hormone it decreased. At the final stages of fatigue development the enhanceable fatigueability of muscle following 1 hour after introduction of dexamethasone has been observed, that kept saved and even increased on the next day after introduction of the hormone.
INFLUENCE OF FACTORS OF PRENATAL DEVELOPMENT ON THE LEVEL OF ADIPONEKTIN IN OBESITY
Authors: Khizhnyak Oksana , Sulima T. N. , Cherevko I. G. , Alekseeva I. I.
Published: June 2022

The content of adiponectin in obese persons was studied. The relationship between insulin resistance and reduced adiponectin concentrations in patients regardless of gender and age has been shown. Evidence is provided that micro- and macrosomies are additional risk factors for low levels of adiponectin in obese individuals.
THE INFLUENCE OF THE FOOD DEPRIVATION STRESS AND HYPOKINESIA UPON ANXIETY PARAMETERS IN FEMALE RATS OFFSPRING OF GESTATIONALLY STRESSED MOTHERS
Authors: Kartavtseva O. V. , Sergienko L. Y. , Perets O. V.
Published: June 2022

The study is aimed at investigating of peculiarities of behaviour in the elevated plus-maze tests in the reproductive female rats whose mothers were stressed only in the first or both in the first and in the third trimesters of pregnancy. It has been shown that offspring of the mothers, stressed both in the first and in the third trimesters of pregnancy, demonstrate more significant changes in behaviour in basal state as well as after starvation and hypokinesia in comparison with the offspring of mothers which were normal or stressed only in the first trimester of pregnancy. The analysis of the indicatedchanges allows us to make a conclusion about the increased level of anxiety in the female rats — offspring of mothers stressed both in the first and in the third trimesters of pregnancy.
INTERACTION OF A NON-ALCOHOLIC LIVER DISEASE AND DEVELOPMENT OF VASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES, THERAPEUTIC APPROACHES
Authors: Kravchun N. A. , Poltorak V. V. , Zemlianitsyna O. V. , Grinchenko T. S. , Gorshunska Maryana , Romanova I. P.
Published: June 2022

Diabetes mellitus (DM) is one of the most widespread diseases in the modern life, in its structure prevails DSD 2, the number of patients with about 250 million persons reach, and the annual occurrence is 5-7%. According to a number of epidemiological investigations, in 24-88% of patients with diabetes are diabetic hepatopathy, among which the non-alcohol fatal disease of the patch (NAKHP) is most often delivered
The role of hormonal factors in regulation and security Sexual function of men
Authors: Minujin Andriy , Bondarenko Volodymyr
Published: June 2022

Our previous analysis of whether the developers was devoted to the role of Androgen, in particular testosterone (T), in ensuring the sexual function (SF) in men. At the same time, the regulation of the SF in men is carried out by other hormones, on the role of which we will focus below
MELATONIN AND ITS POSSIBLE PARTICIPATION IN FUNCTION REGULATION OF THE THYROID GLAND IN PUBERTY PERIOD
Authors: Plekhova O. I. , Turchina S. I.
Published: June 2022

Melatonin production in healthy teens aged 10–16 years and their peers with diffuse non-toxic goiter. On the basis of mathematical analysis of its interaction with thyroid and sexual hormones, thyrotropin, prolactin and type 1 insulin-like growth factor participation of melatonin in the regulation of the hormone-producing function of the thyroid gland, the nature of which depends on the stage of puberty and adolescence.
APPLICATION OF NORMOFTAL IN PATIENTS WITH DIABETIC RETINOPATHY
Authors: Soboleva I. A.
Published: June 2022

The results of the study show that the drug Normophthalic, which has a specific tissue action on the cells of the retina, improves their trophic, which promotes normalization of functional changes. The positive effect of the drug Normophthal was revealed on the visual function. The use of the drug helps to restore the activity of the retina, indicating on the prospect of its use in the treatment of diabetic retinopathy
INFLUENCE OF 17β-ESTRADIOL DERIVATIVE PE0607 ON DEVELOPMENT OF METABOLIC SYNDROME IN CONDITIONS OF HYPERGLYCAEMIA IN OVARIECTOMED RATS
Authors: Taran K. V.
Published: June 2022

The effect of 17β-estradiol derivative PE0607 on the development of metabolic syndrome was studied against the background of hyperglycemia induced by a high-fat diet in combination with dexamethasone, in ovarian chtomed rats. It was found that the introduction of the compound PE0607 inhibits the development of basal hyperglycemia, improves insulin sensitivity and carbohydrate tolerance, reduces visceral obesity and hypertriglyceridemia. The obtained results substantiate the expediency of further study of this compound as a potential agent for pharmacological correction of metabolic of personal disorders inherent in postmenopausal metabolic syndrome on the background of diabetes.
POLYMORPHISM OF THE GENE ENCODING ADIPONEKTIN (+276 G> T ADIPOQ), AND EXPRESSION OF INSULIN-RESISTANT CONDITION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (literature review and own data)
Authors: Karachentsev Yuri , Gorshunska Maryana , Atramentova L. O. , Kravchun N. A. , Khyzhnyak Oksana , Tyzhnenko T. V. , Grinchenko T. S. , Gladkich A. I. , Leshchenko Zhanna , Opaleiko Y. A. , Pochernyayev A. K. , Romanova I. P. , Poltorak V. V.
Published: June 2022

Adiponectin, also known as ACRP30, GBP28 and AdipoQ, is a hormone that is exclusively secreted by adipocytes. For the last several years, he has been paying particular attention to the potential role in the genesis of diabetes. The anti-inflammatory, insulin-sensitizing properties of this hormone, its ability to modulate glucose homeostasis and the metabolism of high-density lipoproteins have been proven.
OBESITY AND OSTEOPATHY - EMBRYONIC DETERMINISTIC LEPTIN-ASSOCIATED DISEASES (Literature review, own data and hypotheses)
Authors: Sergiyenko L. Yu.
Published: June 2022

The results of large-scale epidemiological studies, constantly conducted under the auspices of the World Health Organization in both developed and developing countries, show that, despite the convincing advances made in understanding the etiology and pathogenesis of most diseases, the ongoing diagnosis of drugs, the overall health of the planet's population is declining, and then a small number of years for which MA uvelychyvaetsya srednyaya Duration life, otyahoschaetsya mnohochyslennыmy diseases.
ROLE OF POSTGRANDIAL GLYCEMIA AND SELF-CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Petunina N. A. , Trukhina L. V. , Goncharova E. V.
Published: June 2022

End of XX - beginning of XXI century. were characterized by a rapid increase in the incidence of type 2 diabetes mellitus, which is caused by overeating, an increase in the number of refined products, obesity, a decrease in physical activity, and an increase in life expectancy. Worldwide, the number of people with diabetes is over 100 million. In Europe, the cost of treating diabetes and its complications, according to experts, is 5.8% of the total medical budget
Target network of high-speed railway lines in Mazovia
Authors: Wójcicki Tadeusz
Published: June 2022

High-speed rail (HSR) can bring rail back to an advantage over road and air transport in interurban passenger transport. For this reason, creating a coherent network of high-speed rail lines in Poland and Mazovia makes sense, and the first step in this direction should be the development of a target, comprehensive program for the construction of these lines. Meanwhile, the hitherto arrangements for the construction of HSR in the Mazovian region are fragmentary and controversial in many aspects. In this situation, this study aims to identify the strengths and weaknesses of the findings of the existing HSR development plans in the region, to indicate other ways to solve the already detected weaknesses of these plans, to analyze and evaluate the basic decision-making alternatives, and to select optimal solutions for the Mazovia area. Currently, there are two HSR lines in Mazovia, leading from Katowice and Gdańsk towards Warsaw. Development plans provide for their further modernisation and extension to Warsaw and also provide for the creation of two more lines from Białystok and Łódź to Warsaw. At the same time, the planning documents do not include the construction of HSR exit lines from Warsaw in other geographic directions, although there are also many large cities in these directions. In order to determine whether this omission is justified, the author made a simplified analysis of the passenger traffic generation population for all possible exit directions from Warsaw to other cities, the conclusions of which lead to the legitimacy of supplementing the HSR network in Mazovia with four additional lines from Terespol, Lublin, Kielce and Toruń to Warsaw. Based on preliminary location analyses, the author stated that these additional lines should be essentially new routed lines independent of the existing conventional lines, and only for the Warsaw – Radom section it is possible to route the HSR line in the corridor of the existing conventional line there. There were no significant ecological and natural obstacles in the construction of these lines identified. The author supports creating a strictly radial system of HSR lines with a midpoint in the centre of Warsaw, which will be in accordance with the central role of Warsaw in the agglomeration. He considers the plans to build a “second Warsaw” at the planned Solidarity Transport Hub – STH (Centralny Port Komunikacyjny – CPK) unrealistic and calls for a return to the old concept of the Central Airport (Centralny Port Lotniczy – CPL) with rail services based only on one or two HSR lines.
FARKLI ÖRNEKLEME YÖNTEMLERİNİN YAPAY SİNİR AĞLARINDA PERFORMANSININ KARŞILAŞTIRILMASI
Authors: ULUSLU Ahmet
Published: June 2022

Optimizasyon modelleme problemlerinde, kullanılacak verinin seçimi büyük önem arz etmektedir. Bu çalışmada farklı örnekleme yöntemlerinin Yapay Sinir Ağlarının başarısındaki etkisini, anten tasarımlarında sıkça kullanılan model olan Çok Katmanlı Algılayıcı kullanılarak mikroşerit yama anteni üzerinde performans karşılaştırılması yapılmaktadır. Seçilen Yapay Sinir Ağı kara kutu modeli 5 giriş ve 1 çıkış parametrelerinden oluşmaktadır. Mikroşerit yama anten modellenmesinde kullanılacak veri seçiminde Latin Hiperküp ve Monte Carlo örnekleme yönteminin uygulanması incelenmiştir. Öncelikle örnek sayısı (eğitim ve doğrulama veri setleri) giriş parametrelerinin belirlenen değer aralıklarında Latin Hiperküp ve Monte Carlo örnekleri kendilerine özgün oluşturulma yöntemine göre temin edilmiştir. Akabinde oluşturulan 2 farklı örnek sayısına sahip problemler kendi içlerinde %50 ve %33 oranında rastgele ayrılarak eğitim ve doğrulama verileri oluşturulmuştur. Performans karşılaştırmasında, 3 algoritma ile 4 farklı mimari yapıya sahip toplamda 12 farklı ağ ile birlikte 4 farklı sayıda eğitim ve doğrulama veri setleri kullanılmaktadır. Çıkan sonuçlar birbirleri ile mukayese edildiğinde, düşük veya yüksek eğitim örnek sayısına sahip modellemede de Monte Carlo örnekleme yönteminin performans olarak daha başarılı sonuçlar verdiği görülmektedir. Buna karşın kendi içinde Latin Hiperküp örnekleme yönteminin ise eğitim örnek sayısında artışa gidilmesi kısmi iyileşmeye neden olduğu görülmektedir. Fakat yine de daha az örnek sayısına sahip olan diğer Monte Carlo örnekleme yönteminin performans olarak gerisinde kalmıştır. Dolayısı ile Monte Carlo örnekleme yönteminin bu ve benzer problemler için daha uygulanabilir olduğuna kanaat getirilmiştir.
ANTALYA BÖLGESİNE YAĞAN SIRALI YAĞMUR ÖRNEKLERİNİN KİMYASAL KOMPOZİSYONLARININ VE MORFOLOJİLERİNİN BELİRLENMESİ
Authors: KILIÇ Murat , PAMUKOĞLU Yunus
Published: June 2022

Bu çalışmada, Antalya ili Akdeniz Üniversitesi Kampüs alanında 2020 yılında toplanan fraksiyonel numunelerdeki suda çözünmeyen partiküllerin morfolojik yapılarının, boyut dağılımlarının ve kimyasal bileşimlerinin karakterize edilmesi amaçlanmıştır. Ayrıca her bir yağmur olayının fraksiyonel (sıralı) örneklerinde majör iyonlar ve bu iyonların fraksiyonel dağılımları, nötralizasyon faktörleri belirlenmiş, bulutla taşınan (rainout) ve bulut altı yıkama (washout) mekanizmaları ile hangi oranlarda alıcı ortama geldikleri hesaplanmıştır. Çalışmada kullanılan üç yağmur olayından birisi olan D-serisi, 07.12.2020 tarihinde örneklenmiş ve bu yağmur olayından 4 adet fraksiyonel örnek toplanmıştır. 10.12.2020 tarihli E-serisine karşılık gelen yağmur olayında ise 8 adet ve 12.12.2020 tarihli F-serisi yağmur olayında da 10 adet fraksiyonel yağmur suyu örnekleri toplanmıştır. Elde edilen sonuçlar çeşitli istatistiksel programlar ile değerlendirilerek, çıkan sonuçların veri kaliteleri ve kaynak belirleme çalışmaları yapılmıştır. Örneklerde ortalama pH değerleri 6.06-7.13 aralığında gözlemlenmiş ve herhangi bir şekilde asit yağmuru olasılığına rastlanılmamıştır. Yağmur örneklerinde partikül boyut analiz sonuçlarında D-serisi örneklerde en yüksek ölçülen değer 33.339 µm, E-serisi örneklerde 53.714 µm olarak ölçülmüştür ve F serisi örneklerde ölçüm yapılamamıştır. Örneklenen yağmur olaylarının taşınım bölgelerinin belirlenebilmesi için geri yörünge hesaplamaları yapılmış, kaynak bölgeleri, kaynak türleri ve kirletici içerikleri tartışılmıştır.
MİKROENKAPSÜLE EDİLMİŞ PROPOLİS EKSTRAKTININ MUZ AROMALI PUDİNG ÜRETİMİNDE KULLANIMI
Authors: AKTAŞ Aygül , GÖLGE Evren
Published: June 2022

Bu çalışmada püskürtmeli kurutucuda mikroenkapsüle edilmiş propolis ekstraktı (MPE) %0.05, %0.1 ve %0.2 oranlarında hazır muz aromalı puding formülasyonlarına katılmıştır. Bulgulara göre MPE düzeyinin artışına bağlı olarak depolama süresince puding örneklerinde nem içeriğinde azalma görülmüştür (p
BİTÜMLÜ KAPLAMALARIN SU ETKİLERİNE KARŞI PERFORMANSI ÜZERİNDE ATIK LDPE'NİN ETKİSİ
Authors: GEÇKİL Tacettin , İNCE Ceren Beyza
Published: June 2022

Bu çalışmada, bitümlü kaplamaların su etkilerine karşı performansı üzerinde atık düşük yoğunluklu polietilen (LDPE)’nin etkisi araştırılmıştır. Bunun için, bitüm ile LDPE arasında bir etkileşim sağlamak amacıyla saf B 70/100 bağlayıcısına bağlayıcı ağırlığının % 2,5 kadar trietanolamin (TEOA) eklenmiştir. Elde edilen, bitüm-TEOA harmanına bitüm ağırlığının % 1, 2, 3, 4 ve 5 oranlarında LDPE eklenerek modifiye bitümler elde edilmiştir. Saf ve modifiye bitüm numunelerinin fiziksel özellikleri geleneksel testlerle, bitüm-TEOA-LDPE arasındaki etkileşim ise kimyasal analizlerle belirlenmiştir. Daha sonra, Marshall karışım yöntemi esas alınarak saf bağlayıcı ve agrega ile karışım numuneleri hazırlanmış ve optimum bitüm içeriği (OBİ) tespit edilmiştir. Belirlenen OBİ oranı baz alınarak LDPE modifiyeli sıcak karışım numuneleri hazırlanmış ve bütün karışım numuneleri Marshall stabilite ve akma, kalıcı Marshall stabilitesi (RMS) ve endirekt çekme mukavemeti (ITS) testlerine tabi tutulmuştur. Elde edilen sonuçlarda, atık LDPE katkısı ile bağlayıcıların sertliğinin arttığı ve bitüm-TEOA-LDPE arasında iyi bir etkileşim sağlandığı görülmüştür. Diğer taraftan, özellikle %4 atık LDPE katkılı karışım numunelerinin Marshall stabilitesi, RMS ve endirekt çekme mukavemeti oranı (ITSR) değerlerinde iyileşmeler meydana geldiği ve bitümlü kaplamaların su etkilerine karşı performansının artış gösterdiği görülmüştür.
BULANIK CPM İLE DOĞRUSAL PROGRAMLAMA: İNŞAAT ENDÜSTRİSİNDE BİR VAKA ÇALIŞMASI
Authors: DEĞİRMENCİ Güllü , UĞURAL Mehmet Nurettin
Published: June 2022

İnşaat sektöründe karmaşık projelerin planlanması ve kontrolü için Kritik Yol Metodunun (KYM), yaygın olarak kullanılan yararlı bir araç olduğu kanıtlanmıştır. Ancak, faaliyetlerin süresi net sayılarla temsil edildiğinden, kritik yol analizinde faaliyet sürelerini kesin olarak tahmin etmek zorlaşır. Buna ek olarak, vakaların çoğu, görev sürelerinin sübjektif olarak hesaplanmasını gerektirir ve bu da faaliyetlerin süresi hakkında belirsizliğe neden olur. Bu makale, bulanık kümelere dayalı bir yaklaşım önererek bu sorunları ele almaktadır. Bu çalışmanın amacı, bir inşaat projesinin kritik yolunu ve tamamlanma süresini hesaplamak için bulanık sayıların nasıl kullanılacağını göstermektir. Çalışma kapsamında proje faaliyetlerine üçgen bulanık süreler verilerek iki ayrı çözüm algoritması oluşturulmuştur. Örnek bir inşaat projesinin kritik yolu ve proje süresi ilk çözüm algoritmasında proje faaliyetlerine üçgen bulanık süreler atanarak ve doğrusal programlama modeli kullanılarak hesaplanırken, ikinci çözüm algoritmasında bulanık proje süresi ve kritik yol Alfa kesme yöntemi (α -Kesme Yöntemi) kullanılarak hesaplanmış ve daha sonra Centroid yöntemi (Alanların Merkezi Yöntemi) kullanılarak netleştirilmiştir. Bu proje için kritik yol ve tamamlanma süresi önceden bilindiğinden, iki çözüm algoritması karşılaştırılmıştır. Kritik yol yöntemi yerine Bulanık kritik yol yönteminin kullanılmasının bu çalışmanın önemini vurgulayacağı umulmaktadır.
TEK EKLEMLİ ESNEK ROBOT KOLUNUN SIRALI KONTROL İLE DENETLENMESİ
Authors: ERTAŞ Hacı Ali , ÖRNEK Onur
Published: June 2022

Mekanik sistemler çalışmaları esnasında titreşimlere ve bozucu etkilere maruz kalırlar. Bu etkilerden kurtulmak için çeşitli kontrol yöntemleri geliştirilmiştir. Sıralı kontrol, PID kontrol ve giriş şekillendirmeyi bir araya getiren bir kontrol yöntemidir. Temelinde giriş şekillendirme kullanarak sistemin hızlı ve titreşimsiz bir şekilde istenen referans değerine ulaşması sağlandıktan sonra, anahtarlama yardımıyla PID kontrole geçilerek sistemin bozucu etkilere karşı dayanıklı olmasını sağlamak yatar. Sıralı kontrol, PID kontrol ve giriş şekillendirmeyi optimum zamanlarda kullandığı için, her iki kontrol yönteminin avantajlarından faydalanırken, dezavantajlarından kurtulmayı amaçlar. Sıralı kontrolün, doğru uygulandığında, her iki kontrol yönteminin birlikte kullanıldığı hibrit kontrol yöntemlerinden avantajlı olduğu görülmüştür. Bu çalışmada tek eklemli esnek robotun transfer fonksiyonu MATLAB-Simulink ortamında modellenmiştir. Modellenen sisteme sırasıyla basamak giriş, giriş şekillendirme, PID kontrol ve sıralı kontrol uygulanarak sistem yanıtları elde edilmiş, çıkışlar performans açısından karşılaştırılarak sistem performansının iyileştirilmesi için öneriler sunulmuştur.
EFFECTS OF THE COVID-19 PANDEMIC ON TURKISH NATURAL STONE INDUSTRY: A GREY FORECASTING MODEL
Authors: EKİNCİOĞLU Gökhan , AKBAY Deniz , AYDEMİR Erdal
Published: June 2022

When the indicators in recent years are examined in the developing and renewed economic environment in Turkey, it is seen that the momentum of the natural stone industry and its share in total mining exports have increased steadily. However, the Covid-19 pandemic in 2020, which affected the whole world, also affected the Turkish natural industry. Within the scope of this study, the export values of the Turkish natural stone industry on a monthly and yearly basis were evaluated both before the pandemic and during the pandemic. Export figures for 2020 and 2021 were tried to be estimated using the Gray Forecast model. With the effect of the Covid-19 pandemic, natural stone export figures for 2020 fell behind 2019 in February, March, April and May. With the normalization process in June, July and Months, normalization started in export figures and exceeded the export values of 2019 in September, October, November and December. In 2020, which was entered with great hopes, it was not possible to reach the targeted figures this year due to the pandemic. In addition, Also, export values for 2020 and 2021 were predicted using a GM (1,1) grey forecasting model, which is a method frequently used in uncertainty cases. 2020 and 2021 export values were estimated by using the GM (1,1) gray forecasting model, which is a method frequently used in uncertainty situations. It has been seen that the model can be used reliably to predict natural stone export figures. In the following years, some assessments and recommendations have been made that may make the Turkish natural stone industry stronger in the following years on issues such as health management of crises and adaptation to the current situation if such outbreaks are replicated in the global world economy.
Anesthesiologists With Advanced Degrees in Education: Qualitative Study of a Changing Paradigm
Authors: Aggarwal Anuj , Hess Olivia , Lockman Justin L , Smith Lauren , Stevens Mitchell , Bruce Janine , Caruso Thomas
Published: June 2022

Background

Anesthesiology education has undergone profound changes over the past century, from a pure clinical apprenticeship to novel comprehensive curricula based on andragogic learning theories. Combined with institutional and regulatory requirements, these new curricula have propagated professionalization of the clinician-educator role. A significant number of clinician-educator anesthesiologists, often with support from department chairs, pursue formal health professions education (HPE) training, yet there are no published data demonstrating the benefits or costs of these degrees to educational leaders.

Objective

This study aims to collect the experiences of anesthesiologists who have pursued HPE degrees to understand the advantages and costs of HPE degrees to anesthesiologists.

Methods

Investigators performed a qualitative study of anesthesiologists with HPE degrees working at academic medical centers. Interviews were thematically analyzed via an iterative process. They were coded using a team-based approach, and representative themes and exemplary quotations were identified.

Results

Seven anesthesiologists were interviewed, representing diverse geographic regions, subspecialties, and medical institutions. Analyses of interview transcripts resulted in the following 6 core themes: outcomes, extrinsic motivators, intrinsic motivators, investment, experience, and recommendations. The interviewees noted the advantages of HPE training for those wishing to pursue leadership or scholarship in medical education; however, they also noted the costs and investment of time in addition to preexisting commitments. The interviewees also highlighted the issues faculty and chairs might consider for the optimal timing of HPE training.

Conclusions

There are numerous professional and personal benefits to pursuing HPE degrees for faculty interested in education leadership or scholarship. Making an informed decision to pursue HPE training can be challenging when considering the competing pressures of clinical work and personal obligations. The experiences of the interviewed anesthesiologists offer direction to future anesthesiologists and chairs in their decision-making process of whether and when to pursue HPE training.
Feasibility Analysis of Cassava and Glucose Syrup as Alternatives Raw Materials for Industrial Nata (Case Study at CV. Agrindo Suprafood, Yogyakarta)
Authors: Jumeri Jumeri , Manggala Persia , Cintiadewi Ariesta , Khuriyati Nafis , Purwadi Didik
Published: June 2022

CV Agrindo Suprafood as one of the largest suppliers of nata de coco in Yogyakarta is only able to meet 40% of market demand due to the limitations of coconut water. An alternative strategy to tackle this problem is by looking for coconut water substitute as raw material for the production of nata. The purpose of this study was to analyze the potential of cassava and glucose syrup as raw material alternative of nata and its feasibility on an industrial scale . Formulation of nata is performed on a pilot plant scale with cassava and glucose syrup as raw material. Cassava glucose and glucose syrup were separately used as a growth medium of Acetobacter xylinum for the production of nata. The physical, chemical, and sensory evaluation as well as technical and financial feasibility analysis were conducted on the nata product. The best formula for production of nata de cassava and nata de glucose was obtained by a combination of glucose, glucose syrup, coconut water, ZA,vinegar, and acetic acid. Based on the analysis, it was concluded that both of nata production were industrially-feasible in terms of both technical and financial analysis. However, based on the financial analysis, nata de glucose was more prospective than nata de cassava.
Chemical Composition of Essential Oil of Cendana Frangipani Flower (Plumeria alba) With Re-Extraction Using Ethanol Solvents
Authors: Wartini Ni Made , Putra GP Ganda , Ina Putu Timur
Published: June 2022

One potential source of essential oils in Bali which has not been developed is from cendana frangipani flower. Cendana frangipani flower has a very distinctive scent and very popular in Bali, it has an important function in the local culture, used as fragrances, incense (prayer facilities especially in Bali), and as an air freshener aromatherapy in the spa industry. The fragrance is typical due to their volatile oil which content in the cendana frangipani flower. The quality produced of essential oils are determined by their chemical composition of the extraction process. Previous research indicates that the good quality of frangipani immature essential oil extractedthrough the extraction process using hexane resulting in concrete form which still has the solvent aroma, semi-solid consistency and dark yellow. Therefore, it is necessary tomodifythe process by changing the concrete into the absolute product by re- extraction using ethanol.The purpose of this study was to determine the differences in chemical composition of essential oils of cendana frangipani flowers resulting from the re-extraction by using a particular comparison between ethanol and concrete. Fresh cendana frangipani flowers were sliced and then extracted with n-hexane in a Soxhlet extractor toproduce concrete volatile oil. The concrete was further re-extracted using absolute ethanol to produce essential oil with a concrete and ethanol comparison treatment consisting of 1:4, 1:6, 1:8, and 1:10. Absolute essential oil were then analyzed by GC-MS. The analysis showed that the absolute cendana frangipani flower essential oil produced by different treatment has a different compounds composition and relative percentages varied. The chemical composition of cendana frangipani absolute essential oils was classified as alcohols, terpenes, ketones, esters, and acid with the concentration from 2.65 to 24.77%;0.34 to 1.35%; 0 to 1.38 %; 13.38 to 24.23% and from 22.74 to 58.15% respectively.
The Role of Logistics Service Providers in the Distribution Channel of Imported Perishable and Processed Food Product to Java Island, Indonesia
Authors: Tanuputri Megita Ryanjani , Chaveesuk Ravipim , Guritno Adi Djoko
Published: June 2022

Today fierce competition has highly enforced the company to focus more on their core competency and has encouraged them to strengthen competitive advantage. This condition reinforces the role of logistics service providers (LSP) to help company run their supporting activities. This research aims to identify the characteristics of LSP and to analyze their role in the distribution channel of imported perishable and processed food products in Indonesia. Convenience sampling was employed as sampling methodology and in-depth interview was used to collect detail information from respondents including private stakeholders, port authorities, freight forwarder association and retailers. The research results show that the characteristics and size of the company affects the involvement of LSP in the distribution channel. The roles of freight forwarders (FF) extensively include pre-customs clearance, customs clearance and post-customs clearance. Furthermore, the role of FF considerably contributes to the ease of arranging international shipment. The role of distributor plays vital role in the tracking and tracing system and timeliness of distribution channel. Meanwhile, the role of FF and transporter is fairly low in encouraging track-able and traceable distribution channel. Further improvements are needed to encourage better distribution channel performance.
Shelf Life Determination of Pegagan (Centella asiatica) Chips Using Accelerated Shelf-Life Testing (ASLT) Method
Authors: Sri Wijanarti , Galih Ambarwati , Iman Sabarisman
Published: June 2022

Pegagan (Centella asiatica) is a wild plant with various kinds of efficacies for health and usually as herbal or traditional medicine. Pegagan has been processed into various new products including chips. Pegagan Chips are hygroscopic product that easy to absorb water from the environment. The objective of this study was to determine the shelf life of Pegagan Chips packed in different type of packaging materials. The shelf life of Pegagan Chips was determined using Accelerated Shelf-Life Testing (ASLT) method with a critical moisture content approach. Two different types of packaging used were polyethylene (PE) plastic and standing pouch aluminum foil. The samples were stored at 28°C and RH 75%. The results showed that the shelf life of Pegagan Chips with PE plastic and aluminum foil standing pouch were 83 and 139 days, respectively. Aluminum foil standing pouch possessed lower packaging permeability which was 0.0603 g/m2.day.mmHg compared to PE plastic.