bluuebunny/crossref_metadata_2025 huggingface dataset:
Health-related quality of life in adults born extremely preterm or with extremely low birth weight in the postsurfactant era: a longitudinal cohort study
Authors: Selman Christopher , Mainzer Rheanna , Lee Katherine , Anderson Peter , Burnett Alice , Garland Suzanne M , Patton George C , Pigdon Lauren , Roberts Gehan , Wark John , Doyle Lex W , Cheong Jeanie Ling Yoong
Published: March 2023

Objectives

To compare health-related quality of life (HRQoL) at 25 and 18 years in individuals born extremely preterm (EP, <28 weeks’ gestation) or with extremely low birth weight (ELBW, birth weight <1000 g) with term-born (≥37 weeks) controls. Within the EP/ELBW cohort, to determine whether HRQoL differed between those with lower and higher IQs.

Methods

HRQoL was self-reported using the Health Utilities Index Mark 3 (HUI3) at 18 and 25 years by 297 EP/ELBW and 251 controls born in 1991–1992 in Victoria, Australia. Median differences (MDs) between groups were estimated using multiple imputation to handle missing data.

Results

Adults born EP/ELBW had lower HRQoL (median utility 0.89) at 25 years than controls (median utility 0.93, MD −0.040), but with substantial uncertainty in the estimate (95% CI −0.088 to 0.008) and a smaller reduction at 18 years (MD −0.016, 95% CI –0.061 to 0.029). On individual HUI3 items, there was suboptimal performance on speech (OR 9.28, 95% CI 3.09 to 27.93) and dexterity (OR 5.44, 95% CI 1.04 to 28.45) in the EP/ELBW cohort. Within the EP/ELBW cohort, individuals with lower IQ had lower HRQoL compared with those with higher IQ at 25 (MD −0.031, 95% CI −0.126 to 0.064) and 18 years (MD −0.034, 95% CI −0.107 to 0.040), but again with substantial uncertainty in the estimates.

Conclusions

Compared with term-born controls, young adults born EP/ELBW reported poorer HRQoL, as did those with lower IQ compared with those with higher IQ in the EP/ELBW cohort. Given the uncertainties, our findings need corroboration.
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease
Authors: Cephas Amelia T , Hwang William L , Maitra Anirban , Parnas Oren , DelGiorno Kathleen E
Published: March 2023

Recent advances in single-cell RNA sequencing and bioinformatics have drastically increased our ability to interrogate the cellular composition of traditionally difficult to study organs, such as the pancreas. With the advent of these technologies and approaches, the field has grown, in just a few years, from profiling pancreas disease states to identifying molecular mechanisms of therapy resistance in pancreatic ductal adenocarcinoma, a particularly deadly cancer. Single-cell transcriptomics and related spatial approaches have identified previously undescribed epithelial and stromal cell types and states, how these populations change with disease progression, and potential mechanisms of action which will serve as the basis for designing new therapeutic strategies. Here, we review the recent literature on how single-cell transcriptomic approaches have changed our understanding of pancreas biology and disease progression.
Review of nonlinear modelling parameters and acceptance criteria in ASCE 41 for seismic evaluation and upgrading of steel structures in Canada
Authors: Kim Taeyong , Kwon Oh-Sung , Acosta Joaquín , Fathi-Fazl Reza , Fazileh Farrokh , Cai Zhen
Published: March 2023

The seismic resilience of structures can be quantified through rigorous seismic assessment. Because no detailed guideline is available for nonlinear modelling parameters and the corresponding acceptance criteria for the seismic evaluation and upgrading of steel structures in Canada, the structural commentary of the National Building Code of Canada suggests using ASCE 41, which has been adopted as a standard for seismic evaluation and retrofit of buildings in the United States (U.S.). However, because the steel design standards in Canada and the U.S. are different, their applicability to steel structures in Canada needs to be investigated. To this end, this paper critically reviews the nonlinear modelling parameters and acceptance criteria, and then recommends whether these values need to be revised or are adopted as is for the seismic evaluation and upgrading of steel structures in Canada. A numerical example of a steel moment-resisting frame is presented to demonstrate the recommended parameters being used for seismic evaluation.
THE EXACT TRAVELING WAVE SOLUTIONS OF LOCAL FRACTIONAL GENERALIZED HIROTA–SATSUMA COUPLED KORTEWEG–DE VRIES EQUATIONS ARISING IN INTERACTION OF LONG WAVES
Authors: ZHANG ZONG-GUO , CHEN SU-LING , LIU QUAN-SHENG
Published: March 2023

Wave–wave interaction occurs in the propagation deformation of nonlinear long waves in shallow-water. In order to further study the propagation mechanism of shallow-water long waves interaction, the exact traveling wave solutions of the local fractional generalized Hirota–Satsuma coupled Korteweg–de Vries (HS-KdV) equations defined by the Cantor sets are obtained. The non-differentiable solutions with fixed fractal dimension and different propagation velocity are discussed. The results indicate that the exact solutions of the local fractional generalized HS-KdV equations characterize the interaction of fractal long waves with different dispersion relations on shallow-water surfaces.
Erdős–Ko–Rado theorem for vector spaces over residue class rings
Authors: Guo Jun
Published: March 2023

Let [Formula: see text] be its decomposition into a product of powers of distinct primes, and [Formula: see text] be the residue class ring modulo [Formula: see text]. Let [Formula: see text] be the [Formula: see text]-dimensional row vector space over [Formula: see text]. A generalized Grassmann graph over [Formula: see text], denoted by [Formula: see text] ([Formula: see text] for short), has all [Formula: see text]-subspaces of [Formula: see text] as its vertices, and two distinct vertices are adjacent if their intersection is of dimension [Formula: see text], where [Formula: see text]. In this paper, we determine the clique number and geometric structures of maximum cliques of [Formula: see text]. As a result, we obtain the Erdős–Ko–Rado theorem for [Formula: see text].
Impacts of Market Orientation on Firm Performance in SMEs of Turkey: A Serial Mediation Approach
Authors: Özgül Burcu , Karaca Dilek , Zehir Cemal
Published: March 2023

No previous studies in the literature have investigated the serial mediation impact of innovation capability and product innovation on the influence of market orientation on firm performance. The focus in this research is on the role of the combination of innovation capability and product innovation in the influence of market orientation on firm performance. To that end, it is aimed to examine the direct and indirect impacts of market orientation on firm performance (through innovation capability and product innovation, respectively). The data collected from 739 small and medium-sized enterprises (SMEs) in Turkey by employing the online survey method were tested using the SmartPLS 3 analysis programme. Pieces of empirical evidence have revealed that both market orientation and innovation capability act as important antecedents of product innovation. Moreover, mediation analysis demonstrates that innovation capability and product innovation in turn mediate the connection between market orientation and firm performance. Consequently, this research provides pieces of evidence showing that SMEs can increase their firm performance with innovations they can make in their products by improving their innovation capability with a market-oriented approach so that they can open up to foreign markets in theory and practice.
Multimedia Technology Based Interactive Translation Learning for Students
Authors: Wang Zhiguo , Na Hongwei
Published: March 2023

Multimedia technology incorporates into the educational arena to translate traditional educational material into interactive digital mode. This has permitted teachers into the learning environment to design and integrate interactive multimedia learning. Many problems towards giving more attention to students facing teacher's multimedia levels are uneven, and their integration significance, bringing enormous curriculum learning strategies, is not entirely apparent. This research introduces multimedia network interpretation teaching using machine learning (MNIT-ML)in multimedia education design to enhance and strengthen the traditional teaching process and promote various modern approaches to transmit knowledge towards students.Allocation of learning resources (ALR) framework is mainly to enlarge the use and utilization of materials for learning activities from impressed resources into recordings, video content, motion graphics, and other forms of resources. The purpose of the Allocation of Learning Resources (ALR) framework is to aid teachers in making sound decisions about how to distribute available educational materials. Its goal is to guide teachers in making smart choices about how to use limited resources like time, money, and technology in order to improve students' educational achievements.

The ALR framework was picked because it offers a methodical strategy for selecting choices that is founded in educational research and best practices. Resource allocation is a key aspect in influencing student outcomes, and efficient allocation can help guarantee that all students have access to the tools they need to succeed.

There are a number of alternative frameworks that might direct studies on the distribution of educational resources. The Technological Acceptance Model (TAM) is a common tool for analysing what factors lead to widespread implementation of educational technology.

The goal of other frameworks like the Universal Design for Learning (UDL) framework is to help educators create lessons and methods that are inclusive of students of all backgrounds and abilities.

The final decision on which framework to use will be determined by the nature of the research issues and the setting in which they are being investigated. In order to make educated decisions, it is crucial to pick a framework that is appropriate for the research issues at hand and that gives a systematic approach based on established educational best practices. The digital promoting resources for teaching (DPRT) method creates a real environment for students to learn, focusing on enhancing training to make students feel the standard language translation skills. The simulation analysis is performed based on security 94.6%, the performance of 95.9%, and privacy, proving the proposed framework's reliability overall ratio of 93.4%.
Convolution Representation of Traveling Pulses in Reaction-Diffusion Systems
Authors: Kawaguchi Satoshi
Published: March 2023

Convolution representation manifests itself as an important tool in the reduction of partial differential equations. In this study, we consider the convolution representation of traveling pulses in reaction-diffusion systems. Under the adiabatic approximation of inhibitor, a two-component reaction-diffusion system is reduced to a one-component reaction-diffusion equation with a convolution term. To find the traveling speed in a reaction-diffusion system with a global coupling term, the stability of the standing pulse and the relation between traveling speed and bifurcation parameter are examined. Additionally, we consider the traveling pulses in the kernel-based Turing model. The stability of the spatially homogeneous state and most unstable wave number are examined. The practical utilities of the convolution representation of reaction-diffusion systems are discussed.
An Analysis of the Cloning, Functional Analysis, and Identification of Three Cloned Digestive Enzymes Associated with Growth Traits in Haliotis diversicolor
Authors: Li Weidong , Cao Huaifeng , Xu Wenxin , Mahmood Mohsin , Ahmed Waqas , Mehmood Sajid , You Weiwei
Published: March 2023

The purpose of this study was to determine the effect of different feeds such as Porphyra, Laminaria japonica, Compound feed, and Gracilaria on the activities of alginate lyase, cellulase, and amylase in the digestive juice of H. diversicolor and to take their genes as candidate genes related to the growth traits of H. diversicolor. In order to provide data for selective breeding, SNPs that were significantly associated with growth traits were screened through gene cloning, high-throughput sequencing, and association analysis. It was found that there were no significant differences in the activities of alginate lyase and cellulase in H. diversicolor among different feeds, but there were significant differences between males and females in the group; β-amylase activity is higher than α-amylase activity; the DNA, full-length cDNA, and upstream sequences of genes of alginate lyase, cellulase, and amylase were cloned, and we found that the expressions of three genes are similar; they have started expression in the early prostrate stage of larvae, have tissue specificity in adults, and are highly expressed in hepatopancreas; 84 SNPs were found in alginate lyase through high-throughput sequencing, and 2 which had significant differences were left after associating with growth traits, and they are ALG1016 and ALG1544.
Optimized Reinforcement Learning Approach on Sustainable Rural Tourism Development for Economic Growth
Authors: Chen Guofang
Published: March 2023

A country’s economic development relies on different features such as export/import, industrial processes, and tourism. Rural tourism is a discussion-centric research field for analyzing its contribution to a country’s economic growth. This field generates voluptuous data for tourists, expenditure, location, etc. analysis; the information increases over the years and the density of visiting tourists. Therefore, this article introduces an optimized reinforcement data analysis approach (ORDAA) for generating precise guidance information. This information is two-faced, namely, summarized data for tourist guidance and summarized data for the country’s economic development. Data augmentation’s steep rise and downfall are analyzed using reinforcement learning, wherein decision agents are precise for a relevant summary. The relevance is identified using associated development targets over varying years. Besides, the guidance information that identifies low tourist summary or nonachievable development targets is separately identified. The identified targets are analyzed using reinforcement agents for economic growth improvements compared to the previous tourist densities. This improves the focus on rural tourism sights and economic contributions to an optimal level.
Investigation of a Battery Storage System Aimed at Demand-Side Management of Residential Load
Authors: Ayub Aimen , Khattak Abraiz , Alahmadi Ahmad Aziz , Janjua Abdul Kashif , Ullah Nasim
Published: March 2023

In this paper, an approach is presented for the demand-side management of residential loads in the urban areas of Pakistan using a battery storage system at the feeder level. The proposed storage system will be installed by a private distributor to supply affordable electricity during peak hours. The experimental data used to carry out this research work are the Pakistan Residential Energy Consumption (PRECON) data set. The households of the data set are categorized based on electric power usage through K-means clustering. The clusters are expanded for feeder synthesis to represent small-scale, medium-scale, and large-scale consumption. This expansion is performed through uniform distribution in a Monte Carlo simulation. The techno-economic analysis for the installation of a battery storage system is carried out for each feeder using SAM. The results of the research project elucidated that the load factors of the feeders representing small-scale, medium-scale, and large-scale consumption improved by 1%, 6%, and 7% by using the optimally sized batteries of 50 kW (670 kWh), 90 kW (1207 kWh), and 100 kW (1360 kWh), respectively. The distributor profit and the consumer utility bill savings ranged from US$12 k to US$25 k. The results proved the validity of the used approach to simultaneously reduce the consumer bill, maximize the distributor profit, and improve the feeder load factor. The novelty of this work lies in the location and in the way the system modeling has been performed with limited data.
Existence and Nonexistence of Positive Solutions for a Weighted Quasilinear Elliptic System
Authors: Hamzaoui Yamina , Matallah Atika , Ould El Mokhtar Mohammed El Mokhtar
Published: March 2023

This paper deals with the existence and nonexistence of solutions for the following weighted quasilinear elliptic system,

S

μ

1

,

μ

2

q

1

,

q

2

−
div

q

1

x

∇
u

p
−
2

∇
u

=

μ

1

u

p
−
2

u
+

α
+
1

u

α
−
1

u

v

β
+
1

in 
Ω

−
div

q

2

x

∇
v

p
−
2

∇
v

=

μ

2

v

p
−
2

v
+

β
+
1

u

α
+
1

v

β
−
1

v

in 
Ω

u
>
0
,
 
v
>
0

in 
Ω

u
=
v
=
0

on 
∂
Ω
  
,

where

Ω
⊂

ℜ

N

N
≥
3

,
2
≤
p
<
N

,

q

1

,

q

2

∈

W

1
,
p

Ω

∩
C

Ω
¯

,

α
,
β
≥
0

,

μ

1

,

μ

2

,

≥
0

and

α
,
β
>
0

satisfy

α
+
β
=

p

∗

−
2

with

p

∗

=

p
N

/

N
−
p

is the critical Sobolev exponent. By means of variational methods we prove the existence of positive solutions which depends on the behavior of the weights

q

1

,

q

2

near their minima and the dimension

N

. Moreover, we use the well known Pohozaev identity for prove the nonexistence result.
Three-Dimensional Guidance Approach with Obstacle Avoidance against Maneuvering Targets
Authors: Jiang Zi-jie , Yang Xiu-xia , Zhang Yi , Wang Cong , Yu Hao
Published: March 2023

A guidance approach with obstacle avoidance is proposed for maneuvering target interception. Firstly, by decomposing the constrained optimal guidance problem into two associated subproblems, the overall scheme of guidance is presented. Secondly, to improve the guidance accuracy against the maneuvering target, an MPC controller with disturbance estimation is designed, which transforms the global optimization problem into a finite-horizon optimal control problem. An auxiliary controller is also developed to ensure the system’s stability. Then, to achieve obstacle avoidance without affecting the guidance accuracy, a unified function is built to assess the threats from obstacles of different shapes, based on which the optimal guidance-obstacle avoidance model is established. Finally, to solve the above optimization problems, a hybrid solver is developed based on the adaptive moment estimation (Adam) algorithm, whose output will serve as the real-time guidance command. The numerical simulation results show that the guidance approach presented in this paper can achieve precise guidance and obstacle avoidance in various scenarios, and the Monte Carlo experiment further demonstrates the robustness and computation efficiency of the approach.
Supplementary Methods and Materials from Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism
Authors: Giammarioli Anna Maria , Maselli Angela , Casagrande Andrea , Gambardella Lucrezia , Gallina Angelo , Spada Massimo , Giovannetti Antonello , Proietti Enrico , Malorni Walter , Pierdominici Marina
Published: March 2023

Supplementary Methods and Materials from Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism
Supplementary Methods and Materials from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells
Authors: Krige David , Needham Lindsey A. , Bawden Lindsay J. , Flores Nicolas , Farmer Hannah , Miles Lauren E.C. , Stone Erica , Callaghan Juliana , Chandler Stephen , Clark Vanessa L. , Kirwin-Jones Patricia , Legris Valérie , Owen Jo , Patel Thakor , Wood Steve , Box Gary , Laber David , Odedra Rajesh , Wright Annette , Wood L. Michael , Eccles Suzanne A. , Bone Elisabeth A. , Ayscough Andrew , Drummond Alan H.
Published: March 2023

Supplementary Methods and Materials from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells
Supplementary Figure 2 from Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism
Authors: Giammarioli Anna Maria , Maselli Angela , Casagrande Andrea , Gambardella Lucrezia , Gallina Angelo , Spada Massimo , Giovannetti Antonello , Proietti Enrico , Malorni Walter , Pierdominici Marina
Published: March 2023

Supplementary Figure 2 from Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism
Supplementary Figure 2 from Induction of EBV–Latent Membrane Protein 1–Specific MHC Class II–Restricted T-Cell Responses against Natural Killer Lymphoma Cells
Authors: Kobayashi Hiroya , Nagato Toshihiro , Takahara Miki , Sato Keisuke , Kimura Shoji , Aoki Naoko , Azumi Makoto , Tateno Masatoshi , Harabuchi Yasuaki , Celis Esteban
Published: March 2023

Supplementary Figure 2 from Induction of EBV–Latent Membrane Protein 1–Specific MHC Class II–Restricted T-Cell Responses against Natural Killer Lymphoma Cells
Supplementary Figure 1 from Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism
Authors: Giammarioli Anna Maria , Maselli Angela , Casagrande Andrea , Gambardella Lucrezia , Gallina Angelo , Spada Massimo , Giovannetti Antonello , Proietti Enrico , Malorni Walter , Pierdominici Marina
Published: March 2023

Supplementary Figure 1 from Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism
Supplementary Table 1 from Two Unique Novel Prostate-Specific and Androgen-Regulated Fusion Partners of ETV4 in Prostate Cancer
Authors: Hermans Karin G. , Bressers Anke A. , van der Korput Hetty A. , Dits Natasja F. , Jenster Guido , Trapman Jan
Published: March 2023

Supplementary Table 1 from Two Unique Novel Prostate-Specific and Androgen-Regulated Fusion Partners of ETV4 in Prostate Cancer
Supplementary Figure 1 from Two Unique Novel Prostate-Specific and Androgen-Regulated Fusion Partners of ETV4 in Prostate Cancer
Authors: Hermans Karin G. , Bressers Anke A. , van der Korput Hetty A. , Dits Natasja F. , Jenster Guido , Trapman Jan
Published: March 2023

Supplementary Figure 1 from Two Unique Novel Prostate-Specific and Androgen-Regulated Fusion Partners of ETV4 in Prostate Cancer
Supplementary Tables 1, 3, 5-6, Figures 1-6 from The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer
Authors: Schmidt Marcus , Böhm Daniel , von Törne Christian , Steiner Eric , Puhl Alexander , Pilch Henryk , Lehr Hans-Anton , Hengstler Jan G. , Kölbl Heinz , Gehrmann Mathias
Published: March 2023

Supplementary Tables 1, 3, 5-6, Figures 1-6 from The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer
Supplementary Figure 2E from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Authors: Izadpanah Reza , Kaushal Deepak , Kriedt Christopher , Tsien Fern , Patel Bindiya , Dufour Jason , Bunnell Bruce A.
Published: March 2023

Supplementary Figure 2E from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Figure 2D from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Authors: Izadpanah Reza , Kaushal Deepak , Kriedt Christopher , Tsien Fern , Patel Bindiya , Dufour Jason , Bunnell Bruce A.
Published: March 2023

Supplementary Figure 2D from Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Supplementary Table 1 from MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival
Authors: Jin Hongkui , Yang Renhui , Zheng Zhong , Romero Mally , Ross Jed , Bou-Reslan Hani , Carano Richard A.D. , Kasman Ian , Mai Elaine , Young Judy , Zha Jiping , Zhang Zemin , Ross Sarajane , Schwall Ralph , Colbern Gail , Merchant Mark
Published: March 2023

Supplementary Table 1 from MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival
Supplementary Figure 3 from MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival
Authors: Jin Hongkui , Yang Renhui , Zheng Zhong , Romero Mally , Ross Jed , Bou-Reslan Hani , Carano Richard A.D. , Kasman Ian , Mai Elaine , Young Judy , Zha Jiping , Zhang Zemin , Ross Sarajane , Schwall Ralph , Colbern Gail , Merchant Mark
Published: March 2023

Supplementary Figure 3 from MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival
Supplementary Figure 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells
Authors: Pon Yuen L. , Zhou Hong Y. , Cheung Annie N.Y. , Ngan Hextan Y.S. , Wong Alice S.T.
Published: March 2023

Supplementary Figure 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells
Supplementary Figure 3 from Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance
Authors: Shimamura Takeshi , Li Danan , Ji Hongbin , Haringsma Henry J. , Liniker Elizabeth , Borgman Christa L. , Lowell April M. , Minami Yuko , McNamara Kate , Perera Samanthi A. , Zaghlul Sara , Thomas Roman K. , Greulich Heidi , Kobayashi Susumu , Chirieac Lucian R. , Padera Robert F. , Kubo Shigeto , Takahashi Masaya , Tenen Daniel G. , Meyerson Matthew , Wong Kwok-Kin , Shapiro Geoffrey I.
Published: March 2023

Supplementary Figure 3 from Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance
Supplementary Figure 3, page 1 of 4 from Multiple Alternative Splicing Markers for Ovarian Cancer
Authors: Klinck Roscoe , Bramard Anne , Inkel Lyna , Dufresne-Martin Geneviève , Gervais-Bird Julien , Madden Richard , Paquet Éric R. , Koh ChuShin , Venables Julian P. , Prinos Panagiotis , Jilaveanu-Pelmus Manuela , Wellinger Raymund , Rancourt Claudine , Chabot Benoit , Abou Elela Sherif
Published: March 2023

Supplementary Figure 3, page 1 of 4 from Multiple Alternative Splicing Markers for Ovarian Cancer
Supplementary Figure 5 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Authors: Kumamoto Kensuke , Spillare Elisa A. , Fujita Kaori , Horikawa Izumi , Yamashita Taro , Appella Ettore , Nagashima Makoto , Takenoshita Seiichi , Yokota Jun , Harris Curtis C.
Published: March 2023

Supplementary Figure 5 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Supplementary Figure 1 from Multiple Alternative Splicing Markers for Ovarian Cancer
Authors: Klinck Roscoe , Bramard Anne , Inkel Lyna , Dufresne-Martin Geneviève , Gervais-Bird Julien , Madden Richard , Paquet Éric R. , Koh ChuShin , Venables Julian P. , Prinos Panagiotis , Jilaveanu-Pelmus Manuela , Wellinger Raymund , Rancourt Claudine , Chabot Benoit , Abou Elela Sherif
Published: March 2023

Supplementary Figure 1 from Multiple Alternative Splicing Markers for Ovarian Cancer
Supplementary Figure 3 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Authors: Kumamoto Kensuke , Spillare Elisa A. , Fujita Kaori , Horikawa Izumi , Yamashita Taro , Appella Ettore , Nagashima Makoto , Takenoshita Seiichi , Yokota Jun , Harris Curtis C.
Published: March 2023

Supplementary Figure 3 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Supplementary Tables 1-4 from Promoter Methylation of Genes in and around the Candidate Lung Cancer Susceptibility Locus 6q23-25
Authors: Tessema Mathewos , Willink Randy , Do Kieu , Yu Yang Y. , Yu Wayne , Machida Emi O. , Brock Malcolm , Van Neste Leander , Stidley Christine A. , Baylin Stephen B. , Belinsky Steven A.
Published: March 2023

Supplementary Tables 1-4 from Promoter Methylation of Genes in and around the Candidate Lung Cancer Susceptibility Locus 6q23-25
Supplementary Information from The Signatures of Autozygosity among Patients with Colorectal Cancer
Authors: Bacolod Manny D. , Schemmann Gunter S. , Wang Shuang , Shattock Richard , Giardina Sarah F. , Zeng Zhaoshi , Shia Jinru , Stengel Robert F. , Gerry Norman , Hoh Josephine , Kirchhoff Tomas , Gold Bert , Christman Michael F. , Offit Kenneth , Gerald William L. , Notterman Daniel A. , Ott Jurg , Paty Philip B. , Barany Francis
Published: March 2023

Supplementary Information from The Signatures of Autozygosity among Patients with Colorectal Cancer
Supplementary Methods, Figure 1 Legend , Tables 1-2 from CCN3/Nephroblastoma Overexpressed Matricellular Protein Regulates Integrin Expression, Adhesion, and Dissemination in Melanoma
Authors: Vallacchi Viviana , Daniotti Maria , Ratti Francesca , Di Stasi Delia , Deho Paola , De Filippo Annamaria , Tragni Gabrina , Balsari Andrea , Carbone Antonino , Rivoltini Licia , Parmiani Giorgio , Lazar Noureddine , Perbal Bernard , Rodolfo Monica
Published: March 2023

Supplementary Methods, Figure 1 Legend , Tables 1-2 from CCN3/Nephroblastoma Overexpressed Matricellular Protein Regulates Integrin Expression, Adhesion, and Dissemination in Melanoma
Supplementary Figure 2 from Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies
Authors: Dechant Michael , Weisner Wencke , Berger Sven , Peipp Matthias , Beyer Thomas , Schneider-Merck Tanja , Lammerts van Bueren Jeroen J. , Bleeker Wim K. , Parren Paul W.H.I. , van de Winkel Jan G.J. , Valerius Thomas
Published: March 2023

Supplementary Figure 2 from Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies
Supplementary Video 4 from Abnormal Cytokinesis after X-Irradiation in Tumor Cells that Override the G2 DNA Damage Checkpoint
Authors: Huang Haomin , Fletcher Lynda , Beeharry Neil , Daniel Rene , Kao Gary , Yen Tim J. , Muschel Ruth J.
Published: March 2023

Supplementary Video 4 from Abnormal Cytokinesis after X-Irradiation in Tumor Cells that Override the G2 DNA Damage Checkpoint
Supplementary Table 1 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
Authors: Haugen Astrid C. , Goel Ajay , Yamada Kanae , Marra Giancarlo , Nguyen Thuy-Phuong , Nagasaka Takeshi , Kanazawa Shinsaku , Koike Junichi , Kikuchi Yoshinori , Zhong Xiaoling , Arita Michitsune , Shibuya Kazutoshi , Oshimura Mitsuo , Hemmi Hiromichi , Boland C. Richard , Koi Minoru
Published: March 2023

Supplementary Table 1 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
Supplementary Figure 3b from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Authors: Mitsiades Constantine S. , Ocio Enrique M. , Pandiella Atanasio , Maiso Patricia , Gajate Consuelo , Garayoa Mercedes , Vilanova David , Montero Juan Carlos , Mitsiades Nicholas , McMullan Ciaran J. , Munshi Nikhil C. , Hideshima Teru , Chauhan Dharminder , Aviles Pablo , Otero Gabriel , Faircloth Glynn , Mateos M. Victoria , Richardson Paul G. , Mollinedo Faustino , San-Miguel Jesus F. , Anderson Kenneth C.
Published: March 2023

Supplementary Figure 3b from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Supplementary Tables 1-3, Figure 1 from NO Signaling Confers Cytoprotectivity through the Survivin Network in Ovarian Carcinomas
Authors: Engels Knut , Knauer Shirley K. , Loibl Sibylle , Fetz Verena , Harter Philipp , Schweitzer Andrea , Fisseler-Eckhoff Annette , Kommoss Friedrich , Hanker Lars , Nekljudova Valentina , Hermanns Iris , Kleinert Hartmut , Mann Wolf , du Bois Andreas , Stauber Roland H.
Published: March 2023

Supplementary Tables 1-3, Figure 1 from NO Signaling Confers Cytoprotectivity through the Survivin Network in Ovarian Carcinomas
Supplementary Figure 1 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation
Authors: Marsh Daniel , Dickinson Sarah , Neill Graham W. , Marshall John F. , Hart Ian R. , Thomas Gareth J.
Published: March 2023

Supplementary Figure 1 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation
Supplementary Figure 3 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma
Authors: Chiba Tetsuhiro , Miyagi Satoru , Saraya Atsunori , Aoki Ryutaro , Seki Atsuyoshi , Morita Yohei , Yonemitsu Yutaka , Yokosuka Osamu , Taniguchi Hideki , Nakauchi Hiromitsu , Iwama Atsushi
Published: March 2023

Supplementary Figure 3 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma
Supplementary Figure 3 from Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells
Authors: Darido Charbel , Buchert Michael , Pannequin Julie , Bastide Pauline , Zalzali Hassan , Mantamadiotis Theo , Bourgaux Jean-François , Garambois Véronique , Jay Philippe , Blache Philippe , Joubert Dominique , Hollande Frédéric
Published: March 2023

Supplementary Figure 3 from Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells
Supplementary Table 6 from Epigenetic Signatures of Familial Cancer Are Characteristic of Tumor Type and Family Category
Authors: Joensuu Emmi I. , Abdel-Rahman Wael M. , Ollikainen Miina , Ruosaari Salla , Knuutila Sakari , Peltomäki Päivi
Published: March 2023

Supplementary Table 6 from Epigenetic Signatures of Familial Cancer Are Characteristic of Tumor Type and Family Category
Supplementary Table 4 from Epigenetic Signatures of Familial Cancer Are Characteristic of Tumor Type and Family Category
Authors: Joensuu Emmi I. , Abdel-Rahman Wael M. , Ollikainen Miina , Ruosaari Salla , Knuutila Sakari , Peltomäki Päivi
Published: March 2023

Supplementary Table 4 from Epigenetic Signatures of Familial Cancer Are Characteristic of Tumor Type and Family Category
Supplementary Text 5 from Cell Lineage Analysis of a Mouse Tumor
Authors: Frumkin Dan , Wasserstrom Adam , Itzkovitz Shalev , Stern Tomer , Harmelin Alon , Eilam Raya , Rechavi Gideon , Shapiro Ehud
Published: March 2023

Supplementary Text 5 from Cell Lineage Analysis of a Mouse Tumor
Supplementary Table 3 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Authors: Kikuchi Ryoko , Tsuda Hitoshi , Kozaki Ken-ichi , Kanai Yae , Kasamatsu Takahiro , Sengoku Kazuo , Hirohashi Setsuo , Inazawa Johji , Imoto Issei
Published: March 2023

Supplementary Table 3 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Supplementary Figure Legends 1-4 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Authors: Kikuchi Ryoko , Tsuda Hitoshi , Kozaki Ken-ichi , Kanai Yae , Kasamatsu Takahiro , Sengoku Kazuo , Hirohashi Setsuo , Inazawa Johji , Imoto Issei
Published: March 2023

Supplementary Figure Legends 1-4 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Supplementary Table 2 from Cell Lineage Analysis of a Mouse Tumor
Authors: Frumkin Dan , Wasserstrom Adam , Itzkovitz Shalev , Stern Tomer , Harmelin Alon , Eilam Raya , Rechavi Gideon , Shapiro Ehud
Published: March 2023

Supplementary Table 2 from Cell Lineage Analysis of a Mouse Tumor
Supplementary Figure 3 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Authors: Kikuchi Ryoko , Tsuda Hitoshi , Kozaki Ken-ichi , Kanai Yae , Kasamatsu Takahiro , Sengoku Kazuo , Hirohashi Setsuo , Inazawa Johji , Imoto Issei
Published: March 2023

Supplementary Figure 3 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Supplementary Table 1 from Cell Lineage Analysis of a Mouse Tumor
Authors: Frumkin Dan , Wasserstrom Adam , Itzkovitz Shalev , Stern Tomer , Harmelin Alon , Eilam Raya , Rechavi Gideon , Shapiro Ehud
Published: March 2023

Supplementary Table 1 from Cell Lineage Analysis of a Mouse Tumor
Supplementary Figure 1 from Cell Lineage Analysis of a Mouse Tumor
Authors: Frumkin Dan , Wasserstrom Adam , Itzkovitz Shalev , Stern Tomer , Harmelin Alon , Eilam Raya , Rechavi Gideon , Shapiro Ehud
Published: March 2023

Supplementary Figure 1 from Cell Lineage Analysis of a Mouse Tumor
Supplementary Figure 1 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Authors: Kikuchi Ryoko , Tsuda Hitoshi , Kozaki Ken-ichi , Kanai Yae , Kasamatsu Takahiro , Sengoku Kazuo , Hirohashi Setsuo , Inazawa Johji , Imoto Issei
Published: March 2023

Supplementary Figure 1 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Supplementary Table 1 from Two Distinct Molecular Mechanisms Underlying Cytarabine Resistance in Human Leukemic Cells
Authors: Cai Jie , Damaraju Vijaya L. , Groulx Normand , Mowles Delores , Peng Yunshan , Robins Morris J. , Cass Carol E. , Gros Philippe
Published: March 2023

Supplementary Table 1 from Two Distinct Molecular Mechanisms Underlying Cytarabine Resistance in Human Leukemic Cells
Supplementary Table 1 from AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression
Authors: Zhang Yi-Xiang , Knyazev Peter G. , Cheburkin Yuri V. , Sharma Kirti , Knyazev Yuri P. , Őrfi László , Szabadkai István , Daub Henrik , Kéri György , Ullrich Axel
Published: March 2023

Supplementary Table 1 from AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression
Supplementary Methods and Materials, Figures 1-5 from AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression
Authors: Zhang Yi-Xiang , Knyazev Peter G. , Cheburkin Yuri V. , Sharma Kirti , Knyazev Yuri P. , Őrfi László , Szabadkai István , Daub Henrik , Kéri György , Ullrich Axel
Published: March 2023

Supplementary Methods and Materials, Figures 1-5 from AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression
Supplementary Figure 2 from Skewing the T-Cell Repertoire by Combined DNA Vaccination, Host Conditioning, and Adoptive Transfer
Authors: Jorritsma Annelies , Bins Adriaan D. , Schumacher Ton N.M. , Haanen John B.A.G.
Published: March 2023

Supplementary Figure 2 from Skewing the T-Cell Repertoire by Combined DNA Vaccination, Host Conditioning, and Adoptive Transfer
Supplementary Figure 1 from Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression
Authors: Mahon François-Xavier , Hayette Sandrine , Lagarde Valérie , Belloc Francis , Turcq Béatrice , Nicolini Franck , Belanger Coralie , Manley Paul W. , Leroy Cédric , Etienne Gabriel , Roche Serge , Pasquet Jean-Max
Published: March 2023

Supplementary Figure 1 from Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression
Supplementary Figure 4 from Signal Transducers and Activators of Transcription Mediate Fibroblast Growth Factor–Induced Vascular Endothelial Morphogenesis
Authors: Yang Xinhai , Qiao Dianhua , Meyer Kristy , Friedl Andreas
Published: March 2023

Supplementary Figure 4 from Signal Transducers and Activators of Transcription Mediate Fibroblast Growth Factor–Induced Vascular Endothelial Morphogenesis
Data from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Authors: Zhao Mengjie , Li Yanhui , Lu Chenfei , Ding Fangshu , Xu Miao , Ge Xin , Li Mengdie , Wang Zhen , Yin Jianxing , Zhang Junxia , Wang Xiefeng , Ge Zehe , Xiao Hong , Xiao Yong , Liu Hongyi , Liu Wentao , Cao Yuandong , Wang Qianghu , You Yongping , Wang Xiuxing , Yang Kun , Shi Zhumei , Qian Xu
Published: March 2023

Abstract
Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type of brain tumor. However, resistance to radiotherapy remains a major concern. Identification of mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies for treating patients. Here, we report that mitochondrial metabolic pathways are suppressed in radioresistant gliomas through integrated analyses of transcriptomic data from glioma specimens and cell lines. Decreased expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α), the key regulator of mitochondrial biogenesis and metabolism, correlated with glioma recurrence and predicted poor prognosis and response to radiotherapy of patients with glioma. The subpopulation of glioma cells with low-mitochondrial-mass exhibited reduced expression of PGC1α and enhanced resistance to radiotherapy treatment. Mechanistically, PGC1α was phosphorylated at serine (S) 636 by DNA-dependent protein kinase in response to irradiation. Phosphorylation at S636 promoted the degradation of PGC1α by facilitating its binding to the E3 ligase RNF34. Restoring PGC1α activity with expression of PGC1α S636A, a phosphorylation-resistant mutant, or a small-molecule PGC1α activator ZLN005 increased radiosensitivity of resistant glioma cells by reactivating mitochondria-related reactive oxygen species production and inducing apoptotic effects both in vitro and in vivo. In summary, this study identified a self-protective mechanism in glioma cells in which radiotherapy-induced degradation of PGC1α and suppression of mitochondrial biogenesis play a central role. Targeted activation of PGC1α could help improve response to radiotherapy in patients with glioma.
Significance:
Glioma cells reduce mitochondrial biogenesis by promoting PGC1α degradation to promote resistance to radiotherapy, indicating potential therapeutic strategies to enhance radiosensitivity.
Data from Glioma Formation in Neurofibromatosis 1 Reflects Preferential Activation of K-RAS in Astrocytes
Authors: Dasgupta Biplab , Li Wen , Perry Arie , Gutmann David H.
Published: March 2023

Abstract
Children with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), develop optic pathway gliomas. The NF1 gene product, neurofibromin, functions as a negative regulator of RAS, such that NF1 inactivation results in RAS hyperactivation. Recent studies have highlighted the divergent biological and biochemical properties of the various RAS isoforms, which prompted us to examine the consequence of Nf1 inactivation in astrocytes on RAS isoform activation in vitro and in vivo. In this report, we show that only K-RAS is activated in Nf1−/− astrocytes and that activation of K-RAS, but not H-RAS, accounts for the proliferative advantage and abnormal actin cytoskeleton–mediated processes observed in Nf1−/− astrocytes in vitro. Moreover, dominant inhibitory K-RAS corrects these abnormalities in Nf1−/− astrocytes invitro. Lastly, we show that Nf1+/− mice with astrocyte-specific activated K-RAS expression in vivo develop optic pathway gliomas, similar to our previously reported Nf1+/− mice with astrocyte Nf1 inactivation. Collectively, our results show that K-RAS is the primary target for neurofibromin GTPase-activating protein activity in vitro and in vivo and that K-RAS activation in astrocytes recapitulates the biochemical, biological, and tumorigenic properties of neurofibromin loss.
Data from Expression Analysis of Juvenile Pilocytic Astrocytomas by Oligonucleotide Microarray Reveals Two Potential Subgroups
Authors: Wong Kwong-Kwok , Chang Yi-Mieng , Tsang Yvonne T.M. , Perlaky Laszlo , Su Jack , Adesina Adekunle , Armstrong Dawna L. , Bhattacharjee Meenakshi , Dauser Robert , Blaney Susan M. , Chintagumpala Murali , Lau Ching C.
Published: March 2023

Abstract
Juvenile pilocytic astrocytoma (JPA) is one of the most common brain tumors in children. The expression profiles of 21 JPAs, determined using Affymetrix GeneChip U133A, were compared with subjects with normal cerebella. The genes involved in neurogenesis, cell adhesion, synaptic transmission, central nervous system development, potassium ion transport, protein dephosphorylation, and cell differentiation were found to be significantly deregulated in JPA. These 21 JPAs were further clustered into two major groups by unsupervised hierarchical clustering using a set of 848 genes with high covariance (0.5-10). Supervised analysis with Significance Analysis of Microarrays software between these two potential subgroups identified a list of significant differentially expressed genes involved in cell adhesion, regulation of cell growth, cell motility, nerve ensheathment, and angiogenesis. Immunostaining of myelin basic protein on paraffin sections derived from 18 incompletely resected JPAs suggests that JPA without myelin basic protein–positively stained tumor cells may have a higher tendency to progress.
Data from Wavelet Transformations of Tumor Expression Profiles Reveals a Pervasive Genome-Wide Imprinting of Aneuploidy on the Cancer Transcriptome
Authors: Aggarwal Amit , Leong Siew Hong , Lee Cheryl , Kon Oi Lian , Tan Patrick
Published: March 2023

Abstract
Aneuploidy is frequently observed in many human cancers, but its global effects on the cancer transcriptome are controversial. We did a systematic and unbiased genome-wide survey to determine the extent a tumor's abnormal karyotype (chromosomal amplifications and deletions) is detectably “imprinted” onto that tumor's gene expression profile. By using a novel methodology employing wavelet transform signal-processing algorithms to identify genomic regions of coordinated gene expression (wavelet variance scanning), we analyzed a series of gastric cancer cell lines and identified >100 genomic regions exhibiting distinct patterns of subtle but significant coordinated transcription, ranging from tens to hundreds of genes. A large majority (80%) of these regions could be specifically localized to a site of detectable genomic amplification or deletion; reciprocally, up to 47% of the total aneuploidy in each of the individual cell lines could be directly inferred from the gene expression data. Genome-wide portraits of tumor aneuploidy can thus be successfully reconstructed solely from gene expression data, implying that the effects of aneuploidy must be pervasively and globally imprinted within the cancer transcriptome. Aneuploidy may contribute to tumor behavior not just by affecting the expression of a few key oncogenes and tumor suppressor genes but also by subtly altering the expression levels of hundreds of genes in the oncogenome.