bluuebunny/crossref_metadata_2025 huggingface dataset:
How to deliver gender diversity education to men: Training algorithms to the rescue
Authors: Purvanova Radostina K. , Bryant Andrew
Published: September 2024

Gender diversity training is typically provided to mix‐gender audiences. This one‐size‐fits‐all approach may be suboptimal because information about gender bias and inequity is often received differently along gender lines: men are less likely than women to believe it. We argue for tailoring gender diversity training via implementing segmentation and tailoring algorithms in training systems. To develop our theorizing, we integrate a learner‐centric approach to diversity training with principles of jiu jitsu persuasion theory. This leads us to test a new approach to diversity training that involves dynamic adaptation and tailoring the training to learners. Specifically, we first identify two distinct segments of men—believers and skeptics—and develop a user‐friendly segmentation algorithm that segments men, in real time, using only five items (Study 1). We then use the algorithm to assign segments of men trainees to tailored or non‐tailored training and show that presenting skeptic men with a tailored message improves training reactions and increases intentions to support gender diversity efforts (Study 2). Thus, we show that dynamic adaptation and tailoring successfully explain training outcomes, particularly for trainees who are skeptical of the diversity message. Practically, our study demonstrates the functionality and value of segmentation algorithms for organizations' training systems.
Exploratory study on the individualized application of eltrombopag in paediatric immune thrombocytopenia guided by therapeutic drug monitoring
Authors: Dong Shuyue , Wang Zhifa , Wang Nan , Ma Jingyao , Meng Jinxi , Chen Zhenping , Wu Runhui , Cheng Xiaoling
Published: September 2024

There are variations in individual eltrombopag concentrations that may impact efficacy and adverse drug reactions (ADRs) in paediatric immune thrombocytopenia (ITP). To solve this problem, we tailored the eltrombopag dosage refer to concentration, then followed up to assess concentration value in paediatric ITP. This is a single‐centre, prospective, observational study. The eltrombopag dosage was adjusted, and children were divided into three groups: the maintenance, discontinuation, and increase groups. Concentration and other data were compared to explore concentration value in guiding the individualized treatment of paediatric ITP. Thirty‐nine patients were enrolled, including 23 in the maintenance group, 3 in the discontinued group and 13 in the increase group. 3 patients discontinued eltrombopag due to ADRs, which was significantly higher than patients in the maintenance group (t = 3.606, p = 0.001). In all, 13 patients increased their dosage due to poor response, whose concentration and platelet count were significantly lower than patients in the maintenance group (t = 2.461, p = 0.019; t = 4.633, p < 0.001). Two months after the increase, the number of patients reaching CR and R respectively increased by 2 and 3, while the median platelet count was significantly raised (Z = −2.411, p = 0.016). Concentration could be used as a reference index for the individualized treatment of eltrombopag in paediatric ITP.
ETBHD‐HMF: A Hierarchical Multimodal Fusion Architecture for Enhanced Text‐Based Hair Design
Authors: He Rong , Jiao Ge , Li Chen
Published: September 2024

Text‐based hair design (TBHD) represents an innovative approach that utilizes text instructions for crafting hairstyle and colour, renowned for its flexibility and scalability. However, enhancing TBHD algorithms to improve generation quality and editing accuracy remains a current research difficulty. One important reason is that existing models fall short in alignment and fusion designs. Therefore, we propose a new layered multimodal fusion network called ETBHD‐HMF, which decouples the input image and hair text information into layered hair colour and hairstyle representations. Within this network, the channel enhancement separation (CES) module is proposed to enhance important signals and suppress noise for text representation obtained from CLIP, thus improving generation quality. Based on this, we develop the weighted mapping fusion (WMF) sub‐networks for hair colour and hairstyle. This sub‐network applies the mapper operations to input image and text representations, acquiring joint information. The WMF then selectively merges image representation and joint information from various style layers using weighted operations, ultimately achieving fine‐grained hairstyle designs. Additionally, to enhance editing accuracy and quality, we design a modality alignment loss to refine and optimize the information transmission and integration of the network. The experimental results of applying the network to the CelebA‐HQ dataset demonstrate that our proposed model exhibits superior overall performance in terms of generation quality, visual realism, and editing accuracy. ETBHD‐HMF (27.8 PSNR, 0.864 IDS) outperformed HairCLIP (26.9 PSNR, 0.828 IDS), with a 3% higher PSNR and a 4% higher IDS.
Procurement Trends, Indications, and Outcomes of Heart–Lung Transplantation in the Contemporary Era
Authors: Treffalls John A. , Bilgili Ahmet , Brennan Zachary , Sharaf Omar M. , Griffeth Elaine M. , Chen Qiudong , Pennington Kelly , Spencer Philip J. , Villavicencio Mauricio A. , Daly Richard C. , Saddoughi Sahar A.
Published: September 2024

Background

Evolving trends in organ procurement and technological innovation prompted an investigation into recent trends, indications, and outcomes following combined heart–lung transplantation (HLTx).

Methods

The United Network for Organ Sharing database was queried for all adult (≥18 years) HLTx performed between July 1, 2013 and June 30, 2023. Patients with previous transplants were excluded. The primary endpoint was the effect of donor, recipient, and transplantation characteristics on 1‐ and 5‐year survival. Secondary analyses included a comparison of HLTx at high‐ and low‐volume centers, an assessment of HLTx following donation after circulatory death (DCD), and an evaluation of HLTx volume over time. Cox proportional‐hazards models were used to assess factors associated with mortality. Temporal trends were evaluated with linear regression.

Results

After exclusions, 319 patients were analyzed, of whom 5 (1.6%) were DCD. HLTx volume increased from 2013 to 2023 (p < 0.001). One‐ and 5‐year survival following HLTx was 84.0% and 59.5%, respectively. One‐year survival was higher for patients undergoing HLTx at a high‐volume center (88.3% vs. 77.9%; p = 0.012). After risk adjustment, extracorporeal membrane oxygenation support 72 h posttransplant and predischarge dialysis were associated with increased 1‐year mortality (HR = 3.19, 95% CI = 1.86–5.49 and HR = 3.47, 95% CI = 2.17–5.54, respectively) and 5‐year mortality (HR = 2.901, 95% CI = 1.679–5.011 and HR = 3.327, 95% CI = 2.085–5.311, respectively), but HLTx at a high‐volume center was not associated with either.

Conclusions

HLTx volume has resurged, with DCD HLTx emerging as a viable procurement strategy. Factors associated with 1‐ and 5‐year survival may be used to guide postoperative management following HLTx.
The Effectiveness of Technology‐Enhanced Learning in Prosthodontic Education: A Systematic Review
Authors: Abu Arqub Sarah , Al‐Shehri Nada Ahmed , Meyer Sarah , Asefi Sohrab , Al‐Moghrabi Dalya
Published: September 2024

Objective

To compare the effectiveness of technology‐enhanced learning (TEL) with traditional learning in prosthodontic education.

Methods

The protocol was registered before commencement [CRD42023390277]. The search was conducted to identify randomized controlled trials (RCTs) focused on comparative assessment of TEL and traditional learning in prosthodontic education up to 6 June 2024. A comprehensive search strategy was formulated, encompassing multiple electronic databases. Screening, data extraction and risk of bias assessment using the Cochrane tool (RoB 2) were performed. Educational outcomes were evaluated by Kirkpatrick's four‐level evaluation model.

Results

Of 2830 records identified, 14 RCTs were included. All the trials were judged at high risk of bias or had some concerns. The included studies assessed the short‐term benefits of various TEL approaches, including e‐learning, blended learning, video demonstration specialized self‐evaluation software and virtual reality simulation in prosthodontic education for undergraduates. Promising results were found in individual studies, particularly in terms of perceived learning conditions with problem‐based learning (PBL) and self‐reported understanding and confidence when using video demonstrations. Most studies reported comparable outcomes to traditional learning in practical skills assessments, while the results regarding the acquisition of theoretical knowledge through the incorporation of TEL approaches were contradictory. One study reported promising results in perceived learning conditions with the PBL approach, as well as improved self‐reported understanding and confidence with the use of video demonstrations. Furthermore, there was a limited number of studies assessing the effect of TEL approaches on students' behaviour.

Conclusion

There is a lack of high‐quality evidence to support the adoption of TEL approaches in prosthodontics. However, the incorporation of virtual reality simulation has demonstrated promising results, particularly in improving practical clinical skills.
Otolith elemental composition indicates differences in the habitat use for larvae and early juveniles of Japanese jack mackerel (Trachurus japonicus) in the waters around Japan
Authors: Fujinami Yuki , Takahashi Motomitsu , Sassa Chiyuki , Hiraoka Yuko , Kurota Hiroyuki , Ohshimo Seiji
Published: September 2024

Trace element analysis of otoliths from core to edge was used to reveal differences in habitats of larvae and early juveniles of Japanese jack mackerel (Trachurus japonicus) caught in the East China Sea (ECS), Pacific Ocean, and Sea of Japan. Multi‐element signatures (Sr:Ca, Mg:Ca, Na:Ca, K:Ca, and Ba:Ca) were analyzed with multivariate statistics to determine whether these element signatures provide insight into regional population structure. The median values of elements: Ca ratios in otolith core region differed significantly among areas, with most elements between the ECS and the Pacific Ocean or Sea of Japan showing significant differences. The Sr:Ca ratios exhibited a V‐shaped trend from the otolith core to the edge, which was likely related to the vertical habitat layer shift of larvae and early juveniles of T. japonicus. Canonical analysis of principal coordinates using the element: Ca ratios and the hatching day were re‐classified according to the sampling area with higher accuracy in the ECS (88–95%) and the Sea of Japan (76–83%) compared to the Pacific Ocean (69–72%). These results indicate that the proportion of eggs, larvae, and early juveniles transported by the Kuroshio Current from the southern ECS—the main spawning ground—to the Pacific Ocean or the Sea of Japan is low and that juveniles distributed in the coastal waters off southwestern Japan may have originated from local spawners. These results suggest that determining the elemental composition of larvae and juveniles of T. japonicus is effective in determining the habitat differences of this species in the three regions. These findings will help to understand population structure and recruitment process of this species around Japan.
Pathological features of connective tissue disease‐associated interstitial lung disease in transbronchial cryobiopsies
Authors: Churg Andrew , Poletti Venerino , Ravaglia Claudia , Matej Radoslav , Vasakova Martina Koziar , Hornychova Helena , Stewart Brian , Patel Divya , Duarte Ernesto , Gomez Manjarres Diana C , Mehta Hiren J , Vaszar Laszlo T , Tazelaar Henry , Wright Joanne L
Published: September 2024

Aim

Transbronchial cryobiopsies are increasingly used for the diagnosis of interstitial lung disease (ILD), but there is a lack of published information on the features of specific ILD in cryobiopsies. Here we attempt to provide pathological guidelines for separating usual interstitial pneumonia (UIP) of idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis (FHP) and connective tissue disease‐associated ILD (CTD–ILD) in cryobiopsies.

Methods

We examined 120 cryobiopsies from patients with multidisciplinary discussion (MDD)‐established CTD–ILD and compared them to a prior series of 121 biopsies from patients with MDD‐established IPF or FHP.

Results

A non‐specific interstitial pneumonia (NSIP) pattern alone was seen in 36 of 120 (30%) CTD–ILD, three of 83 (3.6%) FHP and two of 38 (5.2%) IPF cases, statistically favouring a diagnosis of CTD–ILD. The combination of NSIP + OP was present in 29 of 120 (24%) CTD–ILD, two of 83 (2.4%) FHP and none of 38 (0%) IPF cases, favouring a diagnosis of CTD–ILD. A UIP pattern, defined as fibroblast foci plus any of patchy old fibrosis/fibrosis with architectural distortion/honeycombing, was identified in 28 of 120 (23%) CTD–ILD, 45 of 83 (54%) FHP and 27 of 38 (71%) IPF cases and supported a diagnosis of FHP or IPF. The number of lymphoid aggregates/mm2 and fibroblast foci/mm2 was not different in IPF, CTD–ILD or FHP cases with a UIP pattern. Interstitial giant cells supported a diagnosis of FHP or CTD–ILD over IPF, but were infrequent.

Conclusions

In the correct clinical/radiological context the pathological findings of NSIP, and particularly NSIP plus OP, favour a diagnosis of CTD–ILD in a cryobiopsy, but CTD–ILD with a UIP pattern, FHP with a UIP pattern and IPF generally cannot be distinguished.
Effect of boron oxide on the structure and properties of Li2O‐Al2O3‐SiO2 transparent glass‐ceramics
Authors: Jiang Chenxi , Wang Yanhang , Zhu Hanzhen , Liao Qilong , Wang Fu
Published: September 2024

Transparent lithium aluminum silicon glass‐ceramics are prepared via heat treatment and the effect of boron oxide (B2O3) content on the structure and properties of Li2O‐Al2O3‐SiO2 glass‐ceramics is investigated. The X‐ray photoelectron spectroscopy results reveal that the parent glass containing B2O3 exhibits a higher concentration of bridging oxygen (BO). With an increase in B2O3 content, the relative amount of BO changes from 76.64% to 79.86% and then to 79.52%. Simultaneously, the second crystallization peak temperature TP2 of the samples increases from 715°C to 720°C and then to 724°C by differential scanning calorimeter analysis. The X‐ray diffractometer and scanning electron microscope results indicate that the addition of B2O3 facilitates grain growth, while an increase in B2O3 substitution for Al2O3 hinders the precipitation of LiAlSi4O10 but promotes quartz formation. The glass containing 2 wt% B2O3 with the heat treatment of 560°C/ 4 h+ 680°C/2 h shows a Vickers Hardness value of approximately 7.75 GPa, and a transmittance at 550 nm reaching ∼85%.
Trends in drug treatment of benign prostatic hyperplasia in Japan based on the National Database Open Data
Authors: Sasaki Kenichi , Suzuki Motofumi , Nakamura Masaki , Kume Haruki , Nishino Yoshinori , Takahashi Satoru
Published: September 2024

Objective

This study examined prescription trends for benign prostatic hyperplasia (BPH) drug therapy in Japan over the past decade, focusing on drugs rated as grade A according to Japanese clinical guidelines.

Methods

Using the National Database Open Data, this study analyzed prescription data from the fiscal years of 2014 to 2021, tracking α1‐blockers, 5α‐reductase inhibitors, and phosphodiesterase type 5 inhibitors. We adjusted for demographics and calculated medication costs to determine prescribing patterns and changes in drug utilization.

Results

Prescriptions for α1‐blockers increased from 9898 per 1000 males in 2014 to 12 613 in 2021. Prescriptions for 5α‐reductase inhibitors rose from 1441 per 1000 males in 2014 to 2310 in 2021. Tadalafil prescriptions saw a significant increase, from 900 in 2015 to 2520 in 2021. Despite these increases, the overall market size for BPH drugs decreased from 664 million dollars in 2014 to 279 million dollars in 2021, indicating a shift toward generic medications driven by healthcare policies.

Conclusions

Although BPH medication prescriptions are increasing, driven by Japan's aging population and clinical guidelines, market dynamics are shifting owing to generic and government price adjustments. This analysis underscores the changing BPH treatment landscape in Japan, highlighting the importance of continuous evaluation of treatment efficacy and cost‐effectiveness in evolving healthcare policies and demographics.
Vitamin D status and intermediate vascular and bone outcomes in chronic kidney disease: a secondary post hoc analysis of IMPROVE‐CKD
Authors: Yeung Wing‐Chi G. , Toussaint Nigel D. , Lioufas Nicole , Hawley Carmel M. , Pascoe Elaine M. , Elder Grahame J. , Valks Andrea , Badve Sunil V.
Published: September 2024

Background and Aims

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD) and has been associated with abnormalities of mineral metabolism and vascular calcification. Vitamin D influences parathyroid hormone values and calcium and phosphate metabolism, and may play a role in vascular function and bone health. We aimed to test our hypothesis that vitamin D deficiency is associated with arterial stiffness, aortic calcification and lower bone mineral density (BMD) in patients with CKD.

Methods

A cross‐sectional analysis was performed using baseline data from the IMpact of Phosphate Reduction On Vascular Endpoints in CKD (IMPROVE‐CKD) study cohort. Clinical and laboratory parameters were compared between those with and without vitamin D deficiency, defined as 25‐hydroxyvitamin D (25(OH)D) <50 nmol/L. Univariable and multivariable linear regression analyses were performed to assess associations between serum 25(OH)D levels and pulse wave velocity (PWV), augmentation index (AIx), abdominal aortic calcification (measured by the Agatston score) and lumbar spine BMD.

Results

Baseline 25(OHD) values were available in 208 out of 278 IMPROVE‐CKD study participants, with a mean value of 70.1 ± 30.7 nmol/L. Of these, 57 (27%) patients had vitamin D deficiency. Those with 25(OH)D deficiency were more likely to have diabetes (56% vs 38%), cardiovascular disease (54% vs 36%) and lower serum calcium (2.29 ± 0.13 vs 2.34 ± 0.13 mmol/L). On univariable and multivariable regression analyses, baseline 25(OH)D values were not associated with PWV, the AIx, Agatston score or BMD.

Conclusion

Baseline 25(OH)D levels were not associated with intermediate markers of vascular function and BMD in patients with CKD stages 3b and 4.
Characterization of Skoliomonas gen. nov., a haloalkaliphilic anaerobe related to barthelonids (Metamonada)
Authors: Eglit Yana , Williams Shelby K. , Roger Andrew J. , Simpson Alastair G. B.
Published: September 2024

Metamonads are a large and exclusively anaerobic group of protists. Additionally, they are one of the three clades proposed to ancestrally possess an “excavate” cell morphology, with a conspicuous ventral groove accompanied by a posterior flagellum with a vane. Here, we cultivate and characterize four anaerobic bacterivorous flagellates from hypersaline and alkaline soda lake environments, which represent a novel clade. Small subunit ribosomal RNA (SSU rRNA) gene phylogenies support recent phylogenomic analyses in placing them as the sister of barthelonids, a group that is itself sister to or deeply branching within Fornicata (Metamonada). The new isolates have a distinctive morphology: the hunchbacked cell body is traversed by a narrow ventral groove ending in a large opening to a conspicuous recurrent cytopharynx. The right margin of the groove is defined by a thin “lip.” The posterior flagellum bears a wide ventral‐facing vane. The narrow ventral groove and elongate cytopharynx are shared with barthelonids. We describe one isolate as Skoliomonas litria, gen. et sp. nov. Further investigation of their mitochondrial‐related organelles (MROs) and detailed ultrastructural studies would be important to understanding the adaptation to anaerobic conditions in Metamonads—especially fornicates—as well as the evolution of the “excavate” cell architecture.
Size‐dependent release and temperature‐dependent degradation of salmonid environmental DNA under laboratory conditions
Authors: Yamamoto Shoichiro
Published: September 2024

The degradation of environmental DNA (eDNA) and its release from fish were investigated in laboratory experiments for seven salmonid fishes. The eDNA concentration in experimental tanks without fish decreased exponentially, with a higher rate of decline observed under higher water temperature conditions. When a fish was introduced into a tank, the eDNA concentration was positively correlated with the length and weight of the fish.
Histologic findings of gastrointestinal biopsies and clinical outcome in dogs undergoing cholecystectomy for gallbladder mucoceles: 71 cases (2014‐2021)
Authors: Gondolfe M. , Hans E. C.
Published: September 2024

Objectives

To determine the presence and categorise the severity of enteritis in dogs with gallbladder mucoceles, and evaluate for any associations with enteritis. This study also aimed to report clinical outcome following cholecystectomy and evaluate for associations with survival.

Materials and Methods

Medical records were retrospectively reviewed (2014 to 2021) for dogs undergoing cholecystectomy and duodenal biopsy procedures for gallbladder mucocele. Signalment, bloodwork, abdominal ultrasound findings, surgical details, histology results and outcomes were reported. Surgeries were considered elective or emergent based on each dog's clinical presentation. Enteritis was categorised based on cell type and severity. Inflammation and clinical outcome were statistically evaluated.

Results

Seventy‐one dogs met the study criteria. Enteritis was present in 85.9% (61/71) of cases with the majority being lymphoplasmacytic (53.5%). Twelve dogs (16.9%) underwent gastrointestinal biopsies from multiple sites, which revealed the same enteritis type at each location. A total of 87.3% (n = 62) dogs survived, including 90.4% elective and 86% emergent cases. No significant differences in enteritis severity or patient survival were found between elective and emergent cases. Septic peritonitis was diagnosed in two dogs (2.82%). Mortality was significantly associated with leukocytosis, with nonsurviving dogs having a mean WBC count of 27.6 G/L (95% confidence interval: 10.6 to 21.5).

Clinical Significance

Enteritis is present in a majority of dogs with gallbladder mucocele, especially mild to moderate with lymphoplasmacytic cell type. Obtaining a duodenal biopsy had minimal impact on patient outcome. Compared to previous studies, improved survival in emergent cases was noted. Further studies with long‐term follow‐up are needed to determine if enteropathy‐related signs persist after cholecystectomy.
Agrypnia excitata: a human model to explore the derailment of sleep–wake cycle integrated control
Authors: Mutti Carlotta , Baldelli Luca , Cortelli Pietro , Parrino Liborio , Provini Federica
Published: September 2024

The commemoration of the 70th anniversary of rapid eye movement sleep discovery offers a unique possibility to reassess the peculiar organic condition of agrypnia excitata. Agrypnia excitata is characterized by a severe loss of sleep leading to a complete derangement of physiological sleep–wake cycle and body homeostasis. Agrypnia excitata is a definite clinico‐neurophysiological condition characterized by: (1) slow‐wave sleep loss with disruption of sleepwake cycle; (2) a 24‐hr motor and autonomic overactivity; and (3) peculiar episodes of oneiric stupor. Agrypnia excitata may happen within different pathophysiologies, such as delirium tremens, Morvan's syndrome and fatal familial insomnia, suggesting some general reflections on the composition and function of the cerebral neuronal network generating wake and sleep behaviour and regulating body homeostasis, with a focus on rapid eye movement sleep.
Role of ginger in fish nutrition with special emphasis on growth, health, gut and liver morphology
Authors: Ahmad Ishtiyaq , Irm Misbah , Ahmed Imtiaz , Haoran Yin , Taj Sehrish , Bhat Tahir Ahmad , Khan Saba Khursheed , Puswal Sabah Mushtaq , Khalil Hala Saber , Sopjani Mentor , Peres Helena , Faggio Caterina , Rather Mohd Ashraf , Amin Adnan
Published: September 2024

Ginger, Zingiber officinale, is a medicinal herb widely used for its distinct flavor and medicinal properties. It contains various bioactive compounds, including zingerone, shogaols, gingerol saponin, polyphenols, and flavonoids, which confer anti‐inflammatory, antioxidant, and immunomodulatory effects. Ginger and its derivatives such as powder, essential oil, and active ginger extracts have been used as natural functional ingredients with health‐promoting and disease‐preventing properties. In recent studies, ginger derivatives have been tested in aquafeeds for their potential as safe herbal medicines. They have shown several benefits, acting as growth promoters and modulators of physiological and biochemical functions. Ginger has been found to improve growth performance, modulate immunity, and enhance disease resistance in fish. Its organic constituents exhibit potent anti‐stress, antibacterial, antiviral, and antiparasitic activities, thereby boosting the specific and nonspecific immunity of aquaculture fish. This review provides a comphrensive summary of studies exploring the effects of dietary ginger on various aspects of fish health including growth performance, blood parameters, immunity, disease resistance, gut morphology, antioxidant status, and molecular mechanisms. Furthermore, the review emphasizes the necessity of elucidating the specific bioactive compounds in ginger responsible for its biological functions and their mechanisms of action against infectious diseases in different fish species.
Partially funded social security and growth
Authors: Bethencourt Carlos , Kunze Lars , Perera‐Tallo Fernando
Published: September 2024

This paper investigates the relationship between economic growth and the degree of fundedness of a social security system in an overlapping generations model with family altruism. It is shown that the relationship between the degree of fundedness and economic growth is inverted U‐shaped so that a gradual increase in funding may harm growth if bequests are not operative within the family. Our findings put some caution on the conventional view that a higher degree of funded social security is beneficial for growth.
Vigilance and mind wandering
Authors: Murray Samuel
Published: September 2024

Mind wandering is a pervasive feature of experience. But why does the mind wriggle about rather than stay focused? The answer depends on understanding mind wandering as task‐unrelated thought. Despite being the standard view of mind wandering in cognitive psychology, there has been no systematic elaboration of the task‐unrelated thought view of mind wandering. I argue for the task‐unrelated thought view by showing how mind wandering reflects a distinctive form of non‐vigilant thinking. This argument defuses several objections to the task‐unrelated thought view. The account of mind wandering defended here is also compatible with a naturalistic account of subjectivity.
CmMYC2–CmMYBML1 module orchestrates the resistance to herbivory by synchronously regulating the trichome development and constitutive terpene biosynthesis in Chrysanthemum
Authors: Guan Yaqin , Jiang Li , Wang You , Liu Guanhua , Wu Jiayi , Luo Hong , Chen Sumei , Chen Fadi , Niinemets Ülo , Chen Feng , Jiang Yifan
Published: September 2024

Trichomes are specialized epidermal outgrowths covering the aerial parts of most terrestrial plants. There is a large species variability in occurrence of different types of trichomes such that the molecular regulatory mechanism underlying the formation and the biological function of trichomes in most plant species remain unexplored.

Here, we used Chrysanthemum morifolium as a model plant to explore the regulatory network in trichome formation and terpenoid synthesis and unravel the physical and chemical roles of trichomes in constitutive defense against herbivore feeding.

By analyzing the trichome‐related genes from transcriptome database of the trichomes‐removed leaves and intact leaves, we identified CmMYC2 to positively regulate both development of T‐shaped and glandular trichomes as well as the content of terpenoids stored in glandular trichomes. Furthermore, we found that the role of CmMYC2 in trichome formation and terpene synthesis was mediated by interaction with CmMYBML1. Our results reveal a sophisticated molecular mechanism wherein the CmMYC2–CmMYBML1 feedback inhibition loop regulates the formation of trichomes (non‐glandular and glandular) and terpene biosynthesis, collectively contributing to the enhanced resistance to Spodoptera litura larvae feeding.

Our findings provide new insights into the novel regulatory network by which the plant synchronously regulates trichome density for the physical and chemical defense against herbivory.
Extra‐Articular Abscess Expansion as a Specific Complication of Septic Arthritis of the Shoulder Joint: Report of Three Cases with Extension of the Infection through the Biceps Groove Producing a Large Abscess
Authors: Ji Jong‐Hun , Parikh Darshil , Hwang Byung‐Jun , Jeong Jinyoung , Oh Seungbae
Published: September 2024

Background

Septic arthritis of shoulder is a rare clinical entity as the metaphysis is extracapsular and there is no communication between epiphyseal and metaphyseal vessels. Septic arthritis of the shoulder joint is a diagnostic and surgical emergency because joint destruction develops rapidly and can cause significant morbidity and mortality. Unusual complications of septic arthritis of the shoulder joint may include extra‐articular abscess extension to the upper arm through the biceps groove and osteomyelitis of the greater tuberosity.

Case Presentation

Septic arthritis of the shoulder, if left untreated, can lead to complications such as extra‐articular abscess extension and osteomyelitis. Three patients with septic arthritis of the shoulder joint with no clear history of trauma were reported in this study. The initial presentation was pseudoparalysis with upper arm swelling. MRI diagnosed septic arthritis of shoulder joint together with an upper arm abscess. Arthroscopic debridement with through irrigation and open drainage of the extra‐articular abscess extension to the upper arm improved both the shoulder pain and abscess completely. However, if shoulder pain or abnormalities in laboratory findings continue after initial treatment, uncontrolled septic arthritis or secondary osteomyelitis are possibilities that should be concerned. MRI is a useful tool for detecting those atypical complications.

Conclusions

Rarely, septic arthritis of the shoulder joint can extend to the upper arm through the biceps tendon groove and cause an abscess. Also, acute osteomyelitis of the tuberosity should be considered in patients with long‐standing refractory septic arthritis of the shoulder joint who have continued pain and uncontrolled laboratory findings after initial treatment.
Opportunistic Assessment of Hip Fracture Risk Based on Chest CT
Authors: Wang Xiong Yi , Yun Si Min , Liu Wei Feng , Wang Yi Ke , Pan Sheng , Xu You Jia
Published: September 2024

Objective

Hip fracture (HF) has been described as the “last fracture of life” in the elderly, so the assessment of HF risk is extremely important. Currently, few studies have examined the relationship between imaging data from chest computed tomography (CT) and HF. This study demonstrated that pectoral muscle index (PMI) and vertebral body attenuation values could predict HF, aiming to opportunistically assess the risk of HF in patients without bone mineral density (BMD) based on chest CT for other diseases.

Methods

In the retrospective study, 800 participants who had both BMD and chest CT were enrolled from January 2021 to January 2024. After exclusion, 472 patients were finally enrolled, divided into the healthy control (HC) group and the HF group. Clinical data were collected, and differences between the two groups were compared. A predictive model was constructed based on the PMI and CT value of the fourth thoracic vertebra (T4HU) by logistic regression analysis, and the predictive effect of the model was analyzed by using the receiver operating characteristic (ROC) curve. Finally, the clinical utility of the model was analyzed using decision curve analysis (DCA) and clinical impact curves.

Results

Both PMI and T4HU were lower in the HF group than in the HC group (p < 0.05); low PMI and low T4HU were risk factors for HF. The predictive model incorporating PMI and T4HU on the basis of age and BMI had excellent diagnostic efficacy with an area under the curve (AUC) of 0.865 (95% confidence interval [CI]: 0.830–0.894, p < 0.01), sensitivity and specificity of 0.820 and 0.754, respectively. The clinical utility of the model was validated using calibration curves and DCA. The AUC of the predictive model incorporating BMD based on age and BMI was 0.865 (95% CI: 0.831–0.895, p < 0.01), with sensitivity and specificity of 0.698 and 0.711, respectively. There was no significant difference in diagnostic efficacy between the two models (p = 0.967).

Conclusions

PMI and T4HU are predictors of HF in patients. In the absence of dual‐energy x‐ray absorptiometry (DXA), the risk of HF can be assessed by measuring the PMI and T4HU on chest CT examination due to other diseases, and further treatment can be provided in time to reduce the incidence of HF.
A Self‐Regulating Academic Community in Turbulent Times: Ethical Dilemmas in the History of Turkic Studies in Leningrad in the 1930s
Authors: Ikhsanov Anton
Published: September 2024

On February 1931, Russian linguist Sergei Malov sent a complaint to the Union of Education Workers’ Disputes Commission regarding one of his colleagues, Alexander Samoilovich, who was one of the leading Soviet scholars of the time. According to Malov, Samoilovich had used his position and influence to obstruct Malov’s appointment to a professorship for the sole purpose of revenge. Malov demanded an official apology from Samoilovich, certified by the union, for his actions. Scholars who study the history of Oriental Studies in Russia usually focus on the evolution of ideas and approaches within the field, or on the relationship within the profession between knowledge and power. But they have not paid sufficient attention to the self‐regulatory mechanisms that operated within the Soviet Orientologist community. This article argues that during the 1920s and 1930s, a period of great social and political uncertainty, Soviet scholars used “ethics” for specific goals, one of which was to try to limit the scale of intervention by state and party officials in academic life and thereby shelter their community from the unpredictable effects such intervention might have. Malov and Smoilovich, however, attached different meanings to this notion, which consequently played a major role in the collision between the two scholars who previously had been allies.
Asymptotics of the partition function of the perturbed Gross–Witten–Wadia unitary matrix model
Authors: Chen Yu , Xu Shuai‐Xia , Zhao Yu‐Qiu
Published: September 2024

We consider the asymptotics of the partition function of the extended Gross–Witten–Wadia unitary matrix model by introducing an extra logarithmic term in the potential. The partition function can be written as a Toeplitz determinant with entries expressed in terms of the modified Bessel functions of the first kind and furnishes a ‐function sequence of the Painlevé equation. We derive the asymptotic expansions of the Toeplitz determinant up to and including the constant terms as the size of the determinant tends to infinity. The constant terms therein are expressed in terms of the Riemann zeta‐function and the Barnes ‐function. A third‐order phase transition in the leading terms of the asymptotic expansions is also observed.
Patient–clinician interactions in shared diabetes/nephrology consultations – A qualitative observation study
Authors: Christensen Leah Sejrup , Bauer Eithne Hayes , Primdahl Jette
Published: September 2024

Background

The incidence of chronic disease is increasing worldwide which, in turn, increases the demand for healthcare services. To meet these demands, healthcare systems are adapting their services in order to reduce treatment costs and ensure coherence for patients with multiple diseases. One form of adaptation is shared outpatient consultations between internal medical specialties. However, little is known about how patients interact with multiple clinicians in shared consultations.

Aim

This project aimed to explore how patients with diabetes and chronic kidney disease interact with multiple clinicians in a shared outpatient setting.

Research Methods

We performed a qualitative ethnographic study, combining focused participant observations with informal field interviews. We included 17 participants, nine males and eight females with a mean age of 67.3 in the project. The data analysis was guided by Braun and Clarke's reflexive thematic analysis and Arthur Kleinman's theory of illness and disease.

Results

We found one over‐arching theme: ‘A consultation which encompassed both illness and disease’ and four subthemes: (1) ‘The medical focal point’ pertained to the focus on physiological measurements in dialogue between patients and clinicians. (2) ‘The possibility of negotiations’ illustrated how decisions about dialysis and pharmacological treatment were based on negotiations. (3) ‘Speaking different languages’ displayed how patients used alternative illness‐based explanations whereas clinicians tended to use biomedical language. (4) ‘Perceptions of everyday life’ concerned what patients considered was best for them when managing their illness and everyday lives.

Conclusion

Patients present information on how they balance life with physiological and psychosocial challenges. When clinicians employ a biomedical perspective, opportunities to gain information on patients' illness behaviours or cues to negotiate are missed. Patients prioritise functioning on a daily level over following treatment regimes. These findings are tenuous and require verification in similar studies in similar settings.

Short Phrases

Shared Outpatient Clinic, Patient–clinician interactions.
“I felt so small”: A qualitative study of migrant nursing assistants' experiences in Norway
Authors: Khor Heng Wei , El Hajj Magalie , Sam David Lackland , Moland Karen Marie
Published: September 2024

Background

In the wake of an increasingly ageing population, Norway has a growing need for healthcare workers, especially in nursing homes. This study explored the employment experiences of migrant nursing assistants working in elderly care in Norway.

Methods

A qualitative interview‐based study was carried out between March and August 2020. In‐depth, semi‐structured interviews were performed with 13 purposively selected immigrant nursing assistants working in a nursing home within Western Norway. Data were thematically analysed.

Results

Migrant nursing assistants working in Norwegian elderly care faced mixed experiences. On the one hand, study participants experienced several barriers in their workplace, resulting from insufficient command of the Norwegian language, heavy workload and mistreatment and discrimination by both patients and colleagues. On the other hand, participants cited the financial compensation from work, the meaningfulness derived from helping others and the flexible day‐off requests as workplace facilitators. Participants also made continuous efforts to learn the Norwegian language and to build good relations with their co‐workers.

Conclusion

There is a need to enhance migrant nursing assistants' positive experiences in the Norwegian eldercare sector by making targeted workplace reforms and fostering a supportive and inclusive environment.
Evaluation of a whole blood point‐of‐care coagulation analyzer in dogs
Authors: Conroy Elizabeth M. , Lyons Bridget M. , Koenig Amie
Published: September 2024

Objective

To compare the accuracy of a point‐of‐care coagulation analyzer (POCCA) with a reference laboratory coagulation analyzer (LabCA) and to evaluate for confounding factors that could alter the performance of the POCCA.

Design

Prospective, observational study.

Setting

Two university veterinary teaching hospitals.

Animals

Forty‐three client‐owned dogs undergoing coagulation testing between April 2020 and June 2021.

Methods

Samples were obtained from dogs undergoing coagulation testing as part of a diagnostic workup. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured on the POCCA and on the LabCA. PCV, platelet count, total plasma protein, hyperbilirubinemia, hemolysis, lipemia, and autoagglutination were recorded.

Results

Moderate correlation was seen for PT and strong correlation was seen for aPTT between the POCCA and the LabCA (PT: 0.59, P < 0.0001; aPTT: 0.71, P < 0.0001). The POCCA results were consistent with normal or hypocoagulable samples for 30 of 38 PT and 33 of 37 aPTT results, as identified by the LabCA. Samples with PCV of 30%–55% were moderately correlated (PT: 0.63, P = 0.0004; aPTT: 0.63, P = 0.0003), but those outside that range were more likely to register an error message on the POCCA or provide disparate results. When hemolysis was present, there was a weak correlation between the POCCA and the LabCA for PT (rho: 0.38 [95% confidence interval: 0.19–0.76], P = 0.18) and a strong correlation for aPTT (rho: 0.86 [95% confidence interval: 0.62–0.95], P < 0.0001). Samples with hyperbilirubinemia were strongly correlated for PT (0.97, P = 0.002) but not for aPTT. Lipemia and autoagglutination were not observed.

Conclusion

There was an acceptable correlation in patients with PCV within the manufacturer's recommended reference range; however, measurements on samples with PCV outside the reference range were inconsistent with the LabCA. Caution should be used when using the POCCA in patients with coagulopathy and anemia or other potential confounders.
The prototypical UK blood donor, homophily and blood donation: Blood donors are like you, not me
Authors: Ferguson Eamonn , Bowen Sarah , Mills Richard , Reynolds Claire , Davison Katy , Lawrence Claire , Maharaj Roanna , Starmer Chris , Barr Abigail , Williams Tracy , Croucher Mark , Brailsford Susan R.
Published: September 2024

Background and Objectives

Homophily represents the extent to which people feel others are like them and encourages the uptake of activities they feel people like them do. Currently, there are no data on blood donor homophily with respect to (i) people's representation of the average prototypical UK blood donor and (ii) the degree of homophily with this prototype for current donors, non‐donors, groups blood services wish to encourage (ethnic minorities), those who are now eligible following policy changes (e.g., men‐who‐have‐sex‐with‐men: MSM) and recipients. We aim to fill these gaps in knowledge.

Materials and Methods

We surveyed the UK general population MSM, long‐term blood recipients, current donors, non‐donors and ethnic minorities (n = 785) to assess perceptions of the prototypical donor in terms of ethnicity, age, gender, social class, educational level and political ideology. Homophily was indexed with respect to age, gender and ethnicity.

Results

The prototypical UK blood donor is perceived as White, middle‐aged, middle‐class, college‐level educated and left‐wing. Current donors and MSM are more homophilous with this prototype, whereas recipients and ethnic minorities have the lowest homophily. Higher levels of homophily are associated with an increased likelihood of committing to donate.

Conclusion

The prototype of the UK donor defined this as a White activity. This, in part, may explain why ethnic minorities are less likely to be donors. As well as traditional recruitment strategies, blood services need to consider broader structural changes such as the ethnic diversity of staff and co‐designing donor spaces with local communities.
Effectiveness of receiving genetic risk information for cardiovascular disease on health behaviors, psychological responses, and associated risk factor modification in individuals: a systematic review protocol
Authors: Chen Ruofei (Trophy) , Pearson Vincent , Suebkinorn Orathai , Bulto Lemma N. , Anderson Alice , Nelson Adam J. , Zoungas Sophia , Nicholls Stephen J. , Clark Robyn A.
Published: September 2024

Objective:

This review aims to assess the effectiveness of receiving genetic risk information for cardiovascular disease (CVD) on individual health behaviors, psychological responses, and risk factor modification.

Introduction:

Advancements in genomics have identified strong genetic predispositions for CVD, leading to the development of CVD genetic risk information. Integrating genetic risk information into clinical practice shows promise in predicting CVD risk and facilitating multifactorial management.

Inclusion criteria:

This review will focus on randomized controlled trials assessing individual responses to CVD genetic risk information. Participants will be adults aged 18 and older, both with and without CVD. The review will compare the effectiveness of receiving genetic risk information with receiving traditional risk information or no risk information, assessing outcomes such as health behaviors, psychological responses, and risk factor modification.

Methods:

Cochrane CENTRAL, MEDLINE, Embase and Emcare will be searched for relevant studies. Current or unpublished trials will be searched for in Clinical-Trials.gov and World Health Organization International Clinical Trials Registry Platform. Articles will be screened and assessed for inclusion by 2 independent reviewers. Methodological quality will be assessed using the standardized instrument from JBI. Data will be extracted and synthesized for the objectives of the study. If data are sufficient, a meta-analysis will be conducted; otherwise, the findings will be presented in narrative format, including tables and figures to aid in presentation. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.

Review Registration:

PROSPERO CRD42023390876
Elastic Localization With Particular Reference to Tape-Springs
Authors: Clarkson J. A. , Seffen K. A.
Published: September 2024

Many elastic systems localize under applied displacement, precipitating into regions of lower and higher strain; further displacement is accommodated by growth of the high strain region at a constant load. Such systems can be studied as propagating instabilities, focusing on the work required to propagate the high strain region, or as two-phase energy minimization problems. It is shown that the Maxwell “equal-areas” construction, and the related common tangent construction, provide the solution to either approach. A new, graphical, proof of the Maxwell equal-areas construction using total strain energy diagrams is presented. Tape-springs are investigated as a case study, with localization presenting as the formation of elastic folds—developable regions with high curvature. One notable property of tape-spring folds is that the fold radius is approximately equal to the initial transverse radius. This result was first proven by Rimrott, and later improved by Calladine and Seffen. A further improvement is obtained here by application of the common tangent construction, and all solutions are shown to be approximations to the Maxwell equal-areas construction in the limit of zero thickness.