bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Potential Biofertilizer and Bioremediator Bacteria from Upland Soil Based on 16s rDNA Sequence Analysis
Authors: Hadi Sapto Nugroho , Widiyawati Ida , Fauzi Ahmad , Dewi Prita Sari , Ahadiyat Yugi R.
Published: September 2023

The long-term presence of synthetic pesticides on agricultural land can lead to a decline in soil fertility. Synthetic pesticides inhibit the activity of essential enzymes in the soil and suppress beneficial microbial populations for plants. One potential approach to mitigate the extent of contamination caused by synthetic pesticides involves the utilization of indigenous pesticide-resistant bacteria. Several upland soil bacteria from Banyumas Regency, Central Java Province, Indonesia, were successfully isolated from a previous study. The isolated bacteria have the potential to be developed as pesticide bio-remediators and biofertilizers. The bacterial isolates are expected to have characters that support plant growth through their ability to provide dissolved phosphate. However, the potential bacterial isolates need to be identified by molecular approaches. This study was conducted to identify bacterial isolates of GT2, SR1, SW1, and PA1 by 16S rDNA sequencing analysis. The results showed that isolate GT2 was placed within a group of reference strains of Bacillus proteolyticus, isolate SR1 was placed within a group of B. paramycoides, isolate SW1 was set within a group of B. albus, and isolate PA1 was placed within a group of Acidovorax delafieldii. The genetic distance of isolate GT2 and B. B. proteolyticus, isolate SR1 and B. paramycoides, isolate SW1 and B. albus were 0.0000 each, and isolate PA1 and A. delafieldii were 0.0061.
Effects of Micronutrients (Mn and Zn) Fertilizer on the Growth and Production of Sorghum (Sorghum bicolor L.)
Authors: Batubara Siti Fatimah , Chairuman Novia , Aryati Vivi , Siagian Deddy Romulo
Published: September 2023

Micronutrients Mn and Zn are essential elements required in trace amounts, although they play an important role in plant growth. This study aimed to investigate the impact of manganese (Mn) and zinc (Zn) fertilizer on growth and productivity of sorghum. This study was conducted in farmer’s field at Pasar 6 Kwala Mencirim Village, Sei Bingai District, Langkat Regency, North Sumatera started in December 2020 until April 2021. A non-factorial randomized block design with eight treatments and four replications was used, consisted of control (without fertilizer), 100% N, P, K (local fertilizer recommendation), and the level of Mn and Zn fertilizer combined with 75% and 50% dose of N, P, K fertilizer. Measurements were taken for plant height and plant production. The data was analyzed using ANOVA and DMRT at a significance level of 5%, and RAE equation. This study showed that Mn and Zn fertilizers significantly affected sorghum growth and production. The highest productivity was 4770 kg ha-1, while the control was 2260 kg ha-1. This study concluded that applying 1 dose Mn and Zn fertilizer combined with 75% N, P, K increase the yields and reduces 25% the use of N, P, K fertilizers in sorghum field.
T scan – A review on an occlusal indicator in dentistry
Authors: Vishnurao Sowmya Gujjar , Astekar Madhusudan , Aggarwal Ashish
Published: September 2023

Interdisciplinary science has a focus on occlusion. The intricate operation of the stomatognathic scheme depends on achieving optimal physiological occlusion, which differs from person to person. The maximum intercuspation, maximum biting force, first contact force, and centre of force are all recorded by the T-Scan system. An overview of the system and its dental clinical applications is provided in this review.
Awareness, knowledge and attitude towards CPR, BLS training among general population in Chennai – A cross sectional survey
Authors: KG Madhumithra , AI Raj , R Simrutha , R Manikandhan , L Jayanthi , Visweswaran Anandhi
Published: September 2023

Out-of-hospital cardiac arrest is a leading cause of death globally. The likelihood of survival is doubled when basic life support procedures are performed immediately. As a result, the purpose of this study was to assess public awareness, understanding, and attitude towards basic life support and CPR in Chennai population.

The study was done among general population in Chennai, India, utilising a printed questionnaire with 15 questions each. A pilot study was conducted among 40 individuals in Chennai city. Power analysis was performed to calculate the sample size by using Open Epi, Version 3, open – source calculator – SSPropor The data was analysed using descriptive statistics. 1200 individuals participated in the survey.

Of the final population (n =1200) majority of people are unaware about the significance of basic life support and CPR. From this survey we could able to find the positive attitude of public towards learning the CPR. The most important concern about performing CPR was making a mistake and legal issues.

Noteworthy is the positive attitude towards learning CPR & BLS courses among common public, which provides a solid foundation for improving CPR training implementation. However, the majority of youngsters reported a lack of training opportunities, emphasising the need for more aggressive implementation.
Recent developments and initiatives taken by government to ayurveda under ministry of ayush
Authors: Kotadia Hiren , Badiyani J. M.
Published: September 2023

Ayurveda, which means "True knowledge of life" in Sanskrit, is a self-sustainable system of medicine. The Government of India, through its Ministry of AYUSH, is responsible for developing policies and implementing programs for the growth, development, and propagation of Ayurveda. This review aimed to highlight government policies and initiatives for the development of Ayurveda. Various books, policy documents, annual reports, and ancient Ayurvedic literature were critically reviewed, and data was recorded from the Ministry of AYUSH, National Medicinal Plant Board, and Central Council for Research on Ayurvedic Sciences (CCRAS), and AYUSH research portal websites. The vision of the ministry is to position AYUSH systems as the preferred systems for attaining a healthy nation. The ministry has identified its mission in terms of seven broad thematic functional areas of AYUSH activities, including education and communication, human resource development, drug administration, medicinal plants, research and development, international collaborations, and AYUSH services. Various programs have been implemented to increase the visibility, acceptability, and usage of Ayurveda, integrating it into the health system. Strategies are being taken up to promote Ayurveda globally through AYUSH clusters, focusing on safety, efficacy, quality aspects, and rational use of Ayurveda. In conclusion, the government is taking firm steps towards promoting and developing Ayurveda, with a focus on research and development for the validation of Ayurveda.
Analyzing customer satisfaction and loyalty in packaging industry in Rajkot district
Authors: Zala Nehaliba
Published: September 2023

The printing and laminating manufacturing industry in growing rapidly in India. The domestic demand for printed and laminated products is increasing which increase the manufacturing of printing and laminating machines. So it becomes very mandatory to know is the customers satisfied with the product and showing loyalty towards the company. Therefore this research mainly focus on satisfaction and loyalty of customers in packaging industry. Packaging industry include the printing and lamination machinary manufacturing industries. For this research descriptive research methodology is used. Sampling technique used is Convenience (non-random sampling) sampling with sample size of 100 out of all the customers of packaging industry. Data is collected from customers through questionnaire and analysis is done. For statistical analysis Chi square test and Kruskal Wallis test is used. There is applicability of Conceptual Research model which shows that customer service quality and product quality influence the customer satisfaction and customer satisfaction influence the customer loyalty.

This research conclude that 16% customers are elatedly satisfied and 54% customers are highly loyal. Customers are satisfied with the service quality and product quality provided by the packaging industry.
El Greco. Un pintor en el laberinto
Authors:   Universidad de Castilla-La Mancha, Martínez-Burgos Palma
Published: September 2023

El texto se articula en torno a estos tres puntos: - La interpretación que el Greco hace de los grandes artistas italianos que tomó como modelos y cuyas enseñanzas no abandonó nunca. Entre ellos Miguel Ángel, Parmigianino, Correggio, Tiziano, Tintoretto, los Bassano, fueron los que le proporcionaron las lecciones más importantes con las que crea su versión del Manierismo. - El cambio de escala con respecto a lo que pinta en tierras italianas que son en su mayoría obras de pequeño formato, como el Tríptico de Módena o la Adoración de los Magos del Museo Lázaro Galdeano de Madrid. Un cambio de escala que no deja de ser sorprendente y que puede verse en composiciones como la versión de El Expolio de la catedral o El bautismo de Cristo de la colección Lerma-Medinaceli. - La vuelta a la concepción frontal y directa propia de los iconos bizantinos aflorando con fuerza la huella de Bizancio, con la que aportó una concepción religiosa desconocida e impactante como lo fueron las versiones del Apostolado o la Verónica con la Santa Faz.
circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis
Authors: He ZhiYu , Xu Lingling , Zeng Xiaojun , Yang Biqing , Liu Peiying , Han Dunzheng , Xue Hao , Luo Bihui
Published: September 2023

Objective: A recent high-throughput sequencing showed that circular RNA Rho-associated kinase 1 (circROCK1) is abnormally highly expressed in sepsis, but whether it is involved in sepsis development remains unclear. The objective of this study was to investigate the biological function of circROCK1 in sepsis-induced myocardial injury and reveal its potential downstream molecular mechanism. Methods: Real-time reverse transcriptase-polymerase chain reaction was applied to detect circROCK1 and miR-96-5p expressions in the serum of septic patients. Spearman correlation analysis examined the correlation between circROCK1 and the clinicopathological characteristics of septic patients. The Cecal puncture and ligation (CLP) method was used to establish an in vivo sepsis model. circROCK1 and miR-96-5p expressions in mice were modified by injection of lentivirus or oligonucleotide. The left ventricular systolic pressure, left ventricular end-diastolic pressure, and the maximum increase/decrease rate of left ventricular pressure were checked. ELISA was applied to detect inflammatory factors levels as well as myocardial injury markers levels. Hematoxylin and eosin staining was performed to observe pathological changes in myocardial tissues, and Western blot examined phosphorylated nuclear factor (NF)-κB and oxidative stress-responsive 1 (OXSR1) expression. Dual luciferase reporter experiment was conducted to confirm the targeting relationship between circROCK1, OXSR1, and miR-96-5p. Results: circROCK1 and OXSR1 were highly expressed in sepsis and miR-96-5p was under-expressed. circROCK1 was positively correlated with serum creatinine, C-reactive protein, procalcitonin, and sequential organ failure assessment scores in septic patients. Silencing circROCK1 could improve the diastolic and systolic function of CLP mice, as well as myocardial damage, reduce myocardial tissue edema and necrosis, and inhibit inflammatory factor level and phosphorylated NF-κB expression. Down-regulating miR-96-5p promoted myocardial injury in CLP mice. Silencing circROCK1 and miR-96-5p inhibited and promoted OXSR1 expression, respectively. Both circROCK1 and OXSR1 had a targeting relationship with miR-96-5p. Conclusion: CircROCK1 promotes myocardial injury in septic mice by regulating the miR-96-5p/OXSR1 axis, and it can be used as a potential target for treating septic myocardial dysfunction.
Silencing lncRNA EZR‑AS1 induces apoptosis and attenuates the malignant properties of lung adenocarcinoma cells
Authors: Yu Xianjing , Wu Lixue , Lu Zhongcui , Zhang Junli , Zhou Yunfeng
Published: September 2023

Adenocarcinoma is one of the major subtypes of lung cancer. This study aimed to investigate the effect of silencing long non-coding RNA (lncRNA) EZR‑AS1 on the biological behaviors of lung adenocarcinoma (ADC) cells. EZR‑AS1 expression levels in lung ADC tissues and cells, as well as in adjacent non-cancerous tissues, were determined using quantitative reverse transcription polymerase chain reaction (qRT-PCR). EZR‑AS1 was knocked down in two lung ADC cell lines using small interfering RNA specific for EZR‑AS1 (siEZR‑AS1). Proliferation, migration, and apoptosis of EZR‑AS1-knockdown cells were assessed using the CCK-8 viability assay, flow cytometry, or wound healing experiments. The levels of proteins related to migration pathways were evaluated using western blotting analysis. EZR‑AS1 contents were significantly higher in lung ADC tissues and cells than in the levels in the non-cancerous tissues and cells (p<0.01). Transfection of ADC cell lines H1437 and H1975 significantly downregulated EZR‑AS1 levels in both cell lines. Cytotoxicity assays revealed that the viability of EZR‑AS1-knockdown cells significantly decreased over culture time, and a significant level of apoptosis was induced (p<0.01). Wounding healing experiments revealed that EZR‑AS1-knockdown significantly reduced the migration rate of both cell lines (p<0.01). Furthermore, proteins related to migration pathways such as vimentin, MMP2, and MMP9 were significantly downregulated, whereas the E-cadherin level was significantly increased after EZR‑AS1 knockdown. Our work demonstrated that EZR-AS1 is associated with ADC progression, and silencing this gene inhibits proliferation and reduces migration of ADC cells in vitro. The altered expression of metastasis-related genes was likely responsible for the reduced migration ability after EZR-AS1 knockdown.
Modern research problems of modern sociology
Authors:   The Herzen State Pedagogical University of Russia, Perm State Humanitarian Pedagogical University, Perfiljeva Marina B. , Vorontsov Aleksey V. ,   The Herzen State Pedagogical University of Russia, Malyavin Sergey N. ,   The Herzen State Pedagogical University of Russia
Published: September 2023

The article deals with three research problems that the authors consider to be the key ones for modern sociology. This is due to the fact that the modern new world has given rise to new relationships between people and new techniques used by them – put forward new scientific problems for sociology. Once the classics of sociology of the 19th century showed the most important guidelines for the social sciences, which can be expressed by the idea - not only to study, but also to change, and before changing to understand. But these three – research problems, of course, are not the limit for sociology. First of all, and this is the first thing, the authors draw attention to the fact that the modern world, understood as a social system, needs a theoretical explanation based on modern facts and realities of the present time. And the modern sociological picture of the world is in need of revision and rethinking, relying on previous sociological theories. The another direction, or the second sphere of sociological problems, is the development of applied theoretical foundations, or “middle level theories” for empirical research methods. This is especially necessary for empirical research in modern institutions and enterprises aimed at improving the organization of intellectual work. And the third important direction is that is the empirical methods themselves need to be improved in connection with the changed conditions for collecting and processing information. This is due to the fact that Internet surveys have practically replaced personal surveys, new forms of observation are emerging, and digital methods of document analysis have appeared. In this regard, new requirements arise for the formation of a representative sample and the methods for creating valid instruments.
Socio-demographic factors of the regional youth employment
Authors:   Saratov State University, Beginina Irina A.
Published: September 2023

The article presents the results of sociological monitoring conducted by the method of questioning in Saratov in 2022. According to the probabilistic quota sample, 480 people from 18 to 30 years old were interviewed. The selection criteria are gender and age. The results were processed in the SPSS program. The study showed that Saratov youth are mainly distinguished by paternalistic moods in employment, but, depending on gender, age and marital status, they have significant differences in their orientations and problems. So the gender factor is manifested in the fact that young men are more active in the regional labor market. However, they were more likely to face the problem of low wages with large amount of work. Describing the level of difficulty in finding a job, most girls noted that it is very difficult due to lack of experience. They would like to get help in finding employment from educational institutions, but in reality, when looking for a job, they often resort to the help of government agencies. Not less important is the age factor. Under its impact, young people under the age of 24 more often than the elders remained committed to their place of work, combining it with improving their education and finding a job in their specialty. They are more focused on individual achievements, reflected in the size of salaries. Problems with employment were less common among young Saratov residents than among mature youth. For them, the most problematic thing is the lack of experience. The main difficulty is to find a job with a flexible work schedule. 25–30 year olds are characterized by increased mobility and demanding work. Mature youth care more about the realization of their inner potential and social recognition from others. They more often stated a high level of complexity of employment. The older faced the problems of low wages, lack of experience and large amount of work more often. Only they are registered at the labor exchange, waiting for assistance in employment from the university. Marital status also affects the employment patterns of young people. It contributes to a stable attitude to work. Those who live without marriage registration, as well as non-family young people, often do not work and are looking for work in their specialty. They are 6 times more concerned about the amount of earnings than others. They are more often focused on independence in employment. Single and unmarried youth are more likely than others look for work aimed at career growth.
World sociodynamics of rural communities in the Russian village
Authors:   Agrarian Problems – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Center of the Russian Academy of Sciences, Veliky Petr P. , Dakirova Svetlana T. ,   Agrarian Problems – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Center of the Russian Academy of Sciences
Published: September 2023

Based on many years of sociological research, the article analyzes the sociodynamics of the state of a number of characteristics of rural communities world: consciousness, behavior, values, and objective prerequisites for changes. The world of rural communities consists of reflection and action in public and private life, based on the historical experience. The sociodynamics of socio-cultural processes is revealed in the context of the influence of economic practices that combine borrowed innovations and traditions of peasant culture. The organization of agricultural production, at the first stage based on Western models, turned out to be largely untenable, since business entities approached it from the standpoint of traditionally peasant and post-Soviet culture. Confidence in one’s own culture will remain a domain of rural residents in the future. The world of rural society in Russia is permeated with the meanings of interaction and cohesion, logically connected with the ethos of life “in the world”, which are genetically inherent in the peasantry, and survived in the post-reform period on the basis of the socio-economic activity of the most creative part of the inhabitants, and so far poorly manifested in the formalized socio-economic space of the agro-industrial complex.
Unregistered marriage in the assessments of young people under the conditions of Russian society transformation
Authors:   Maikop State Technological University, Kobleva Zuret Kh.
Published: September 2023

Under modern conditions, the institute of family and marriage relations is of stable research interest in the context of the transformation processes of society associated with the spread of various forms and models of unregistered marriage, which are popular among modern youth. Due to its institutional features, unregistered marriage has a number of advantages, in which the absence of legal foundations of marriage and mutual obligations between partners play a crucial role in choosing the forms and models of the future family. It was found that the most common form of unregistered marriage relations in the modern youth environment is a "trial marriage", which allows to identify the partners` mutual interest degree in the process of living together in the conditions of interpersonal interaction, revealing the specifics of such marriage unions, which do not always justify the ideas of young people about the essence of family-marriage relations. The analysis of empirical data on the problem under study indicates the presence of contradictory trends in the attitude of young people to the phenomenon of unregistered marriage, characterized by a pronounced individualization of the values of the younger generation, reflecting the desire of young people to abandon traditional forms of family and popularize alternative forms of marriage.
Modernization of the educational potential under the conditions of partial military mobilization in Russia
Authors:   Saratov Military Order of Zhukov Red Banner Institute of the National Guard Troops, Balandina Taisiya M. , Bychenko Yuriy G. ,   Saratov Military Order of Zhukov Red Banner Institute of the National Guard Troops
Published: September 2023

The specific problems of the development of the educational potential of Russians related to the sharp aggravation of the military confrontation in the world, the intensification of hostilities in the Ukraine, the implementation of partial mobilization, as well as the mobilization of educational training of part of the economically active population of Russia are clarified. Theoretical developments devoted to the study of educational potential are analyzed, and these concepts are conditionally ranked into interdisciplinary, general sociological and military-sociological ones. The integration of different views made it possible to substantiate the need to clarify the trend in the development of the educational potential of the population as a set of knowledge, skills, abilities, culture and practical experience of individuals in the areas of both general and partially military-professional action. The hypothesis is put forward according to which the modernization of the educational potential of the population under the conditions of partial military mobilization in Russia involves: updating its content (introduction of additional military educational components); saturation of scientific and spiritual quality (accumulation of the innovative component of the abilities of its carriers); allocation of adaptive potential as an independent component of self-development (accumulation of the adaptive component of the abilities of carriers of educational potential). The ways of modernization of the educational potential of Russians are presented. The first one is the transition to a comprehensive and continuous formation of educational potential. At all levels of general, professional, and additional education, there should be a dual target orientation: general and special civil; general military. The second one is the formation of a proactive (proactive) type of formation of educational potential. In the education system it is important: to transform the nature of scientific and investment flows; to activate the channels of socio-cultural mobility; to reverse the saturation of civilian and military human capital of trainees and trainees. The third one is the allocation of adaptive potential as a separate component of educational potential. It is proved that under the new conditions, the realization of educational potential depends on the ability of individuals to quickly assess changes in the external social environment, adapt, form new models of influence in the process of work, service, military influence on the enemy. Adaptive educational potential is proposed to be considered as a characteristic of an individual's educational abilities to adapt their own activities in both peacetime and wartime.
Russia-Germany energy cooperation: How paradigm change affects Germany’s economy and politics
Authors:   Moscow State Linguistics University, Rukavitsyn Pyotr M.
Published: September 2023

The article analyzes the economic and political consequences for Germany of the essentially total breakdown of Russia-Germany cooperation on energy. The author notes that the breakdown jeopardizes Germany’s entire contemporary economic model built around imports of cheap Russian energy resources and makes the country increasingly dependent on the US and other exporters of hydrocarbons to keep its economy afloat. Special attention is given to political consequences of the crisis, including emerging geopolitical and domestic issues. The West consolidation to counter Russia and, further out in time China, is forcing Germany to sacrifice pragmatic defense of its national priorities in favor of the West’s ideological interests. Domestic consequences of the disrupted Russia-Germany energy cooperation include dissent growing within and among the political parties that make up the ruling coalition; deteriorating public approval of the federal government; increasing likelihood of dramatic changes in Germany’s Party system; and intensifying protests instigated by right-wing extremists in the East Germany States.
Attitude of Russian youth to the special military operation in Ukraine: Impact of media practices
Authors:   Saratov State University, Kazakov Alexander A. , Vilkov Alexander A. ,   Saratov State University, Shestov Nikolay I. ,   Saratov State University
Published: September 2023

According to social surveys, the majority of Russian society as a whole supported the President’s decision to hold the special military operation (in what follows, the SMO). However, the level of this support appeared to be different for different social groups. It turned out, for example, that, compared with society in general, young people perceived the outbreak of hostilities more skeptical and critical. In this regard, this article is devoted to the analysis of the features and factors of formation of such an attitude of young people towards the SMO. Among other things, the views of young people about the causes of the outbreak of the conflict, its perpetrators and possible solutions are considered; the reaction of young citizens of the country to the entry into Russia of four new subjects, partial mobilization, as well as those who evade it is presented. Patterns are indicated according to which people’s media preferences affect the nature of their assessments of events within the framework of SMO. Probable reasons for the more skeptical attitude of the younger generation to what is happening are identified, and possible options for its further transformation in the short and long terms are indicated.
State regulation of activities of foreign agents in the Russian Federation: Evolution of the industry law in 2012–2022
Authors:   Lomonosov Moscow State University, Saygushinskaya Sofia A.
Published: September 2023

The regulation of foreign agents’ activities as part of ensuring the security of Russian sovereignty, the constitutional order and national interests from the foreign influence is one of the key directions of the development of Russian politics and society nowadays. The actuality of this problem is driven by the presence of internal and external threats. The article presents the prerequisites for the adoption of regulation regarding foreign agents’ activities in the Russian Federation. The need for regulatory unification in 2022, caused by the presence of relevant regulation regarding foreign agents’ activities in difference law sources for ten years, is described in the article; as a result, various types of these entities have become standardized within the framework of the modern political process, ensuring the most effective government control. In addition, the main regulatory mechanisms regarding foreign agents’ activities in different countries have been analyzed. On the basis of this work the comparative analysis of regulatory measures concerning foreign agents in Russia and other countries has been carried out. Great attention was paid to articles of domestic and foreign authors, explaining the emergence of such a phenomenon as foreign agents. The dynamics of the inclusion of foreign agents has been analyzed. The author finds that the legislative reform, carried out in 2022, equalizing foreign agents in terms of the requirements, eliminated the legal and management gaps. The results, presented in the article, allow to draw the conclusions concerning the current situation of foreign agents in the Russian Federation.
Experimental Researches of Elements and Constants of Didactics
Authors:   Saratov State Agrarian University, Berdnova E.V.
Published: September 2023

In clause results of experimental researches of elements and the constants of didactics described earlier in work of the author «Elementary didactics» are resulted. Speed of comprehension of the information, speed of mastering of new knowledge, the base constant representing the attitude of quantity of base knowledge to quantity of that it is supposed to master during training are carried to them, quantity of the characteristics forming an image, and an age threshold of training. Quantum character of storing at a level of operative memory (at a level of consciousness) and average disorder of volumes of formation of long-term memory (at a level of subconsciousness) at modern youth is established.
Problems and Prospects of Social Psychology of Education
Authors:   Saratov State University, Shamionov R.M.
Published: September 2023

On October 26−27, 2010, at the Faculty of Pedagogy, Psychology and Primary Education of the Pedagogical Institute of Saratov State University, on the initiative of the Department of Educational Psychology, the International Scientific Conference “Problems and Prospects of Social Psychology of Education” was held, dedicated to the 105th anniversary of the birth of Doctor of Psychology, Professor I.V. Strakhov.
Destructive Forms of Socialization of Youth in the Nonconventional Religious Organizations and Sects
Authors:   Saratov State University, Kuzmin A.V.
Published: September 2023

In the article the problems connected with processes of socialization of modern youth in the nonconventional religious organizations and sects, received the wide circulation in territory of Russia are analyzed recently. The basic characteristics of a phenomenon of nonconventional religiousness are designated, the criteria of disruptiveness sects are given, the analysis of existing researches on this theme is carried out.
The Special Thought: A. Piatigorsky on the Transcendental Unity of the Philosopher and His Philosophy
Authors:   Kazan (Volga Region) Federal University, Melikhov G.V.
Published: September 2023

This article is a philosophical commentary on the thesis A. Piatigorsky of the transcendental unity of the philosopher and his philosophy.
Becoming Grammatica Speculativa: Analysis of Some Features of Realism, Conceptualism and Nominalism in the Decision of Problem of Universalies
Authors:   Tyumen State University, Nekhaev A.V.
Published: September 2023

In article are analyzed and compared features of decisions of «universalies problem» offered by such scholastic traditions as realism, conceptualism and nominalism played a key role in becoming of problem field of logical-semiotic researches medieval grammatica speculativa.
Transcendental the Reduction in Platos Metaphysics
Authors:   Vladimir State University, Semenov V.E.
Published: September 2023

In the article epistemological and methodological procedure in Platos metaphysics is considered. It will be named later in history of philosophy by transcendental the reduction. Its functions and results are analyzed.
S.N. Bulgakov's Spiritual Searches and Their Reflection in His Philosophical System
Authors:   Kaluga State Pedagogical University named after K.E. Tsiolkovsky, Senina O.V.
Published: September 2023

Article is devoted to research philosophical views of S.N.Bulgakov. Questions of formation of weltanschauung of Bulgakov through a prism of inconsistent events in his life and philosophical researches in his creative work became an analysis subject. They are especially interesting now when ample opportunities of a choice of philosophical ideas, religious faiths and ordinary views are given for the person. His optimism and integrity of humanistic maintenance of all his life is attractive to spiritual formation of the person.
She-Truth: The Experience of Female Gnoseologization
Authors:   Volgograd State Agricultural Academy, Shadrina L.N.
Published: September 2023

The article is an attempt to reconceive gnoseological symbol «She- Truth». She-Truth does not tempt philosophical mind, does not deprive it of Its creativity. She-Truth emancipates philosophical mind, gives it creative impetus and protects philosophers personality.
Theoretical-Experimental Bases of Socio-Emotional Cultures Formation of Orphan Adolescent Personal Culture
Authors:   Orenburg State Medical Academy, Malikov L.V.
Published: September 2023

An attempt to consider socio-emotional development of adolescents, brought up out of family, from the point of view of socio-emotional culture on basis of cultural-historical theory was undertaken. The methodological basis of factor analysis and development conditions of socio-emotional cultures of orphan adolescent in educational environment is presented here. The direction and logic of experimental investigation was define. The factors, influencing on success of socioemotional culture development of interpersonal relations were characterized.
Formation of Students Subjectivity in the Educational Space of Faculty of Arts
Authors:   Saratov State University, Rachimbaeva I.E.
Published: September 2023

The article discusses the problem of personality of the students in the education space. Raises issues finding of meaning in the process of learning and the formation of subjective stance on training activities.
Kinds and Functions of Borders in Psychological Research
Authors:   Saratov State University, Ryaguzova Ye.V.
Published: September 2023

In the present article an analysis of borders diverse kinds and functions applied in psychological concepts and paradigms has been carried out. It has been made clear that a comprehension of borders as a self-valuable source for development ousts metaphorical and topological interpretations of the term. It has been alleged that within the context of social psychology it is righteous to discuss intersubject and intersubjective borders of interaction between I and the Other.
Subject Fact in Philosophy B. Russell and L. Wittgenstein
Authors:   Saratov State University, Ilichev A. A.
Published: September 2023

The article characterizes the concept of «fact» in the philosophy B. Russell and L. Wittgenstein. Analyzed the position these scientists. Identifies similarities and differences in understanding the issues the problems of fact in the philosophy of neo-positivism and the so-called first positivism. The fact becomes is not the original reality, but a conceivable limits of the logical analysis of statements.
The Social Representations of Risk
Authors:   Saratov State University, Klenova M. A.
Published: September 2023

In this article results of the analysis of a place and a role of risk in system of social representations are discussed. The structure of social representations about risk is studied. Inter-generation features of perception of risk are analyzed.
Structure of Activity and Condition of Mental Burning Out at Teachers of City and Rural Comprehensive
Authors:   Kursk State Medical University, Molchanova L. N.
Published: September 2023

Studying of a condition of mental burning out of city and rural teachers with use of the theory about functional psychological system of activity as methodological basis allows to reveal specific displaying of a structure of professional work (its objective and subjective conditions) on its occurrence and genesis.
Reseach of the Younger Teenagers Intellectual Qualities under the Developing Effect to their Emotionally-Volitional Sphere
Authors:   Chuvash State Pedagogical University named after I. Ya. Yakovlev, Slavutskaya E. V.
Published: September 2023

The interrelations between the emotional, volitional qualities and intelligence quotients of the younger teenagers are studied. During three years we carry out the experiment in diagnostics and development emotionally-volitional sphere of schoolchildren of 9−12. The correlative and factorial analysis of the received psychodiagnostic results, which was obtained before and after experiment, was used. The diagnostic and correctional-developing methods are presented. We show that the influence on emotionallyvolitional sphere has the significant effect on schoolchildren intellectual qualities.
Components of Students Productive Generalizing Educational Activity
Authors:   Saratov State University, Parinova G. K.
Published: September 2023

Analysis of components of students' productive generalizing educational activity is made in connection with each sphere of developing person. This analysis gave the opportunity to plan educational product, consisting of valuable orientations, productive generalization and experience of creative activity.
Features of the Organization of the Cadets Independent Work in Military Educational Establishments of the Higher Professional Training of the Ministry of Internal Affairs of Russia
Authors:   Saratov Military Institute of the Ministry of Internal Affairs of the Russian Federation, Hutchev S. N.
Published: September 2023

On the basis of the features comparison of the independent works organization of students in high civil institutes and cadets VOU VPO the Ministry of Internal Affairs of Russia is specified parameters of developed model of pedagogical management by militaryprofessional cadets self-development which is offered to realize into the educational process on Firing dill faculty of Saratov military institute the Internal Troops of Ministry of Internal Affairs.
Regional Development Platform based on ‘Related Variety’: Some Evidences from Tuscany
Authors: Lazzeretti Luciana , Capone Francesco , Cinti Tommaso
Published: September 2023

Regional Development Platform based on ‘Related Variety’: Some Evidences from Tuscany A recent contribution toregional/local development is the Regional Development Platform (RDP), a tool oflocal policy and governance meant for theplanning and implementation of a regional innovation systemwith a sustainable and long-lasting competitive advantage. The aimof the present work is to contribute to the debate on local economic development throughplatforms of regional development,offering some specific cases in which the RDP model is developed notonly as a top-down policy tool in support to innovation,but also as a bottom-up governance tool for therelationships among cognitively-related industries. Finally, we also introducethe idea of the platform as ‘apublic space’ able to foster ideas and innovations through cross-fertilisation according to aRelated-varietyapproach.
In the management of febrile neutropenia; evaluation of the factors affecting the lenght of hospital stay
Authors: YILMAZ Fatma , SAĞLAM Buğra , REİS ARAS Merih , AFACAN ÖZTÜRK Hacer Berna , ÇAYKÖYLÜ Hafize Hilal , YAPICI GÜLÇİÇEK Aylin Merve , GÜNEŞ Ahmet Kürşad , ALBAYRAK Murat
Published: September 2023

Aim: Febrile neutropenia (FEN) is one of the most serious and commonly seen complications of patients receiving chemotherapy for a diagnosis of hematological malignancy. FEN is an emergency condition with mortality rates reaching 40% because of an increase in antimicrobial-resistant pathogens in particular. In a situation with such high mortality rates, parameters that can predict prognosis play an important role in the approach to the patient. The aim of this study was to investigate the parameters that could affect prognosis in the follow-up of FEN. Material and Methods: The study included 58 patients hospitalised in the Hematology Clinic with a diagnosis of FEN. The patients were evaluated in respect of the recorded demographic characteristics, blood group, MASCC score, hemogram, procalcitonin, C-reactive protein (CRP), Interleukin-6 (IL-6), D-dimer, fibrinogen, pre-albumin, albumin, HbA1c, anthropometric measurements and length of stay in hospital. Results: According to the statistical analysis results, patients with a length of hospital stay of ≥14 days were determined to have a significant decrease in the MASCC score and thrombocyte count and the procalcitonin, Il-6, D-dimer values and the number of antibiotics used were higher. No significant difference was determined between the groups in respect of the other parameters. Conclusion: In the management of febrile neutropenia, the most important points are the establishment of indications for hospitalisation, rapid and early recognition of a worsening status and intervention made in the right place at the right time. Parameters with prognostic benefit will help the clinician in decision-making.
The NOS 3 gene polymorphism –786T>S (rs2070744) as the risk factor of hemodynamic disorders in Northerners
Authors: Averyanova I. V. , Bezmenova I. N.
Published: September 2023

Objective. This research assessed the influence of polymorphism –786T>C (rs2070744) of the NOS3 gene on the hemodynamic impairments in the Northern residents. Design and methods. One hundred and one volunteers of Magadan region, mainly Caucasians by ethnicity, underwent molecular genetic examination, and a continuous method was used to form the study sample. DNA was isolated by phenol-chloroform extraction followed by polymorphism genotyping by the polymerase chain reaction. Results. In male Northerners, the following percentage variation in the genotype frequencies by the eNOS locus (rs2070744) was found: –786ТТ — 42,57 %, –786ТС — 43,56 %, –786СС — 13,87 %. The concentration of the eNOS *C allele was 35,64 %, the ancestral eNOS *T allele occurred with the frequency of 64,36 %. The observed distribution of frequencies of alleles and genotypes corresponded to the Hardy-Weinberg equilibrium (χ2(HWE) = 0.26, p > 0.05). The presence of even one eNOS *C allele in the genotype causes a significant increase in diastolic blood pressure level. The lowest blood pressure (80,3 ± 5,9 mmHg) was found in male homozygotes by the ancestral eNOS *T allele, while the T/C heterozygotes and the C/C homozygotes showed significantly higher blood pressure (83,2 ± 7,3 and 82,9 ± 3,7 mmHg, respectively). The individuals with the C/C genotype showed lower cardiovascular adaptabilities, in particular lower indicators of stroke volume (SV, 43,6 ± 3,7 mL) and cardiac output (CO, 2836,3 ± 182,4 mL/min) with a significant increase in total peripheral vascular resistance (TPVR, 3028,3 ± 252,7 dyn2 s cm-5) compared to the T/T homozygotes (SV, 49,6 ± 7,9 mL; CO, 3393,1 ± 546,8 mL/min; TPVR, 2572,8 ± 559,4 dyn2 s cm-5). Conclusions. This study showed that the eNOS *C allele is associated with the hemodynamic disorders. These results can be used to calculate the risk of cardiovascular pathologies at younger ages, which can develop under the North extremes.
The efficacy of antihypertensive therapy according to the results of the CONSONANCE program: is achieving the target blood pressure level the sole criterion?
Authors: Lopatin Yu. M. , Nedogoda S. V. , Galyavich A. S. , Kashtalap V. V. , Nechaeva G. I. , Lyamina N. P. , Nedoshivin A. O. , Ratova L. G. , Shaposhnik I. I. , Konradi A. O.
Published: September 2023

Objective. This study aims to assess the efficacy of single-pill combination ramipril/indapamide (Konsilar-D 24) in patients with grade 1 and 2 hypertension who did not achieve blood pressure (BP) control through previous therapy or did not receive antihypertensive treatment in routine clinical practice. The assessment is based on home BP monitoring (HBPM), long-term BP variability, and quality of life according to the visual analog scale (VAS) EuroQol. Design and methods. A multicenter open observational program involved 358 CONSONANCE program patients who provided home BP monitoring (HBPM) data and self-monitoring diaries for all visits. Among them, 326 patients (91,1 %) evaluated their well-being using VAS at each visit. The program protocol was approved by the independent ethics committee of the Almazov National Medical Research Centre (protocol № 200219 от 11.02.2019). All participants provided written informed consent before inclusion. Clinical BP changes were evaluated at baseline, 0,5, 1, 3 and 6 months into treatment. Patients measured their BP daily for the initial 2 weeks and then at least 3 times a week. The average of two consecutive measurements represented each reading. The effectiveness criterion for HBPM was achieving an average BP < 135/85 mm Hg. Visit-to-visit BP variability was assessed using standard deviation (SD). Patients self-assessed their quality of life by the VAS EuroQol scale from 1 to 100 points. Statistical analysis was performed with the use of Statistica 10. Quantitative variables were presented as means and standard deviations, and their changes were evaluated using paired Student’s t-test. Qualitative features were compared using McNemar’s test with Yates’ continuity correction. A p-value < 0,05 denoted statistical significance. Results. After 2 weeks of treatment, 268 (74,9 %) patients achieved clinical BP < 140/90 mm Hg, the number increased up to 356 (99,4 %) after 6 months. For home BP, 271 (75,7 %) and 326 (91,1 %) patients reached the target after 2 weeks and after 6 months, respectively. Visit-to-visit BP variability, while on unchanged antihypertensive therapy, was 4,1 ± 2,3 / 2,5 ± 1,1 mm Hg for clinical BP and 4,5 ± 3,5 / 2,8 ± 1,9 mm Hg for home BP. The initial VAS score was 54,7 ± 19,1 points, increasing to 86,6 ± 6,1 points after  6 months of treatment (a change of 31,9 ± 18,5 points; p < 0,0001). Conclusions. Optimizing antihypertensive therapy with the single-pill combination ramipril/indapamide (Consilar D 24) effectively reduces both clinical and home BP, leading to the swift achievement of the target BP level for most patients with previously uncontrolled arterial hypertension. Treatment with this single-pill combination also reduces visit-to-visit BP variability and enhances patients’ quality of life in real clinical settings.
History of the study of arterial hypertension from Cesalpino to the 21st century
Authors: Galyavich A. S.
Published: September 2023

The article describes the main milestones in the study of hypertension (HTN). In a chronological aspect, the main discoveries in the field of hypertension since the 16th century are presented. The contribution of Russian scientists to the field and approaches to its treatment is noted. The facts related to the development of national recommendations on HTN is presented.