bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 1 from LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer
Authors: Zhao Tiansuo , Ren He , Li Jing , Chen Jing , Zhang Huan , Xin Wen , Sun Yan , Sun Lei , Yang Yongwei , Sun Junwei , Wang Xiuchao , Gao Song , Huang Chongbiao , Zhang Huafeng , Yang Shengyu , Hao Jihui
Published: April 2023

BxPC-3 and Panc-1 cells were transfected with pcDNA3.1 and pcDNA3.1-LASP1 plasmids (2 μg) for 48 h and assessed by RT-PCR and Western blot analyses.
Supplementary Information from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy
Authors: Hsieh Chen-Lin , Botta Ginevra , Gao Shuai , Li Tiantian , Van Allen Eliezer M. , Treacy Daniel J. , Cai Changmeng , He Housheng Hansen , Sweeney Christopher J. , Brown Myles , Balk Steven P. , Nelson Peter S. , Garraway Levi A. , Kantoff Philip W.
Published: April 2023

Supplementary Information
Suppl Figure 4 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy
Authors: Hsieh Chen-Lin , Botta Ginevra , Gao Shuai , Li Tiantian , Van Allen Eliezer M. , Treacy Daniel J. , Cai Changmeng , He Housheng Hansen , Sweeney Christopher J. , Brown Myles , Balk Steven P. , Nelson Peter S. , Garraway Levi A. , Kantoff Philip W.
Published: April 2023

Suppl Figure 4. To evaluate the inhibitory effect of MAPK inhibitors on of PLZF depleted LNCaP cells
Supplementary Table S1 from TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability
Authors: Pommier Roxane M. , Gout Johann , Vincent David F. , Alcaraz Lindsay B. , Chuvin Nicolas , Arfi Vanessa , Martel Sylvie , Kaniewski Bastien , Devailly Guillaume , Fourel Geneviève , Bernard Pascal , Moyret-Lalle Caroline , Ansieau Stéphane , Puisieux Alain , Valcourt Ulrich , Sentis Stéphanie , Bartholin Laurent
Published: April 2023

List of all up-regulated genes in Tif1γ-/--primary MEFs compared to control-primary MEFs (fold {greater than or equal to}1.70).
Supplementary Methods and References from TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability
Authors: Pommier Roxane M. , Gout Johann , Vincent David F. , Alcaraz Lindsay B. , Chuvin Nicolas , Arfi Vanessa , Martel Sylvie , Kaniewski Bastien , Devailly Guillaume , Fourel Geneviève , Bernard Pascal , Moyret-Lalle Caroline , Ansieau Stéphane , Puisieux Alain , Valcourt Ulrich , Sentis Stéphanie , Bartholin Laurent
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S6 from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Figure S6. FOXM1 increases ER transcriptional activity and correlates with resistance to estrogen deprivation.
Supplementary Figure S2 from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Figure S2. Validation of PLK1, RPS6KA2 and GSG2 knockdown.
Supplementary Table S5 from MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
Authors: Tatti Olga , Gucciardo Erika , Pekkonen Pirita , Holopainen Tanja , Louhimo Riku , Repo Pauliina , Maliniemi Pilvi , Lohi Jouko , Rantanen Ville , Hautaniemi Sampsa , Alitalo Kari , Ranki Annamari , Ojala Päivi M. , Keski-Oja Jorma , Lehti Kaisa
Published: April 2023

Supplementary Table S5. Proteins which shedding/release to conditioned media was changed more than 20% after MMP16 knockdown in Proteome Profiler Array.
Supplementary Table S2 from Cables1 Complex Couples Survival Signaling to the Cell Death Machinery
Authors: Shi Zhi , Park Hae R. , Du Yuhong , Li Zijian , Cheng Kejun , Sun Shi-Yong , Li Zenggang , Fu Haian , Khuri Fadlo R.
Published: April 2023

Supplementary Table S2. Human lung tumor sample histology information and IHC scoring summary.
Supplementary Information from Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
Authors: Doçi Colleen L. , Mikelis Constantinos M. , Lionakis Michail S. , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Supplementary methods, figure legends, and references.
Supplementary Table S1 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Primers of murine DNA deep sequencing analysis.
Supplementary Figure S3 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Supplementary Figure S3. RNAseq data sets derived from The Cancer Genome Atlas (TCGA) showed various levels of AID mRNA expression in human pancreatic adenocarcinomas (N: Number). In addition, AID mRNA expression level in human pancreatic adenocarcinoma was higher than the mean AID mRNA expression level in all cancer types.
Supplemental Table 1 from Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma
Authors: Cheng Hanyin , Terai Mizue , Kageyama Ken , Ozaki Shinji , McCue Peter A. , Sato Takami , Aplin Andrew E.
Published: April 2023

Supplementary Table 1: Characteristics of patient samples.
Supplementary Figure S1 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Supplementary Figure S1. The images of laser capture microdissection for PanIN lesion of AID Tg mouse.
Supplemental Figure 7 from Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma
Authors: Cheng Hanyin , Terai Mizue , Kageyama Ken , Ozaki Shinji , McCue Peter A. , Sato Takami , Aplin Andrew E.
Published: April 2023

Supplementary Figure 7: AKT inhibitor effects and NRG1/HGF rescue in an additional cell line.
Supplemental Figure 6 from Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma
Authors: Cheng Hanyin , Terai Mizue , Kageyama Ken , Ozaki Shinji , McCue Peter A. , Sato Takami , Aplin Andrew E.
Published: April 2023

Supplementary Figure 6: Effects of cMET silencing and HGF rescue.
Supplementary Table S5 from IL13 Receptor α2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis
Authors: Bartolomé Rubén A. , García-Palmero Irene , Torres Sofía , López-Lucendo María , Balyasnikova Irina V. , Casal J. Ignacio
Published: April 2023

List of proteins involved in transport and co-immunoprecipitated with FAM120A
Supplementary Figure S4 from Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma
Authors: Zhao Jian-Jun , Chu Zhang-Bo , Hu Yu , Lin Jianhong , Wang Zhongqiu , Jiang Meng , Chen Ming , Wang Xujun , Kang Yue , Zhou Yangsheng , Chonghaile Triona Ni , Johncilla Melanie E. , Tai Yu-Tzu , Cheng Jin Q. , Letai Antony , Munshi Nikhil C. , Anderson Kenneth C. , Carrasco Ruben D.
Published: April 2023

Supplementary Figure S4. Increased drug resistance to apoptosis in V-miR-221-222-GFP stable transduced MM1S cells.
Supplementary Figure S3 from Intracellular Osteopontin Inhibits Toll-like Receptor Signaling and Impedes Liver Carcinogenesis
Authors: Fan Xiaoyu , He Chunyan , Jing Wei , Zhou Xuyu , Chen Rui , Cao Lei , Zhu Minhui , Jia Rongjie , Wang Hao , Guo Yajun , Zhao Jian
Published: April 2023

Supplementary Figure S3. The effects of extracellular OPN on cytokine production in macrophages.
Supplemental PVG Figure 3 from A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Unger Jakob , Lohscheller Jörg , Reiter Maximilian , Eder Katharina , Betz Christian S. , Schuster Maria
Published: April 2023

Supplemental PVG Figure 3. The phonovibrogram (PVG) from each subject of the cancer group is shown. The PVG is explained more detailed within the manuscript.
Supplementary Figure S6 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: April 2023

Supplementary Figure S6. Iron rescues archazolid induced reduction of metabolic activity in 4T1 cells.
Supplementary Movie 2 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: April 2023

Supplementary Movie 2. Final images where the computed aggregate outline and center were drawn in red. Time is indicated at the top left. Time origin was set at the end of the centrifugation step.
Supplementary Figure 5 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

ÃŽÂ²III-tubulin shRNA NSCLC cells show increased maspin expression.
Supplemental Materials and Methods from Erlotinib Pretreatment Improves Photodynamic Therapy of Non–Small Cell Lung Carcinoma Xenografts via Multiple Mechanisms
Authors: Gallagher-Colombo Shannon M. , Miller Joann , Cengel Keith A. , Putt Mary E. , Vinogradov Sergei A. , Busch Theresa M.
Published: April 2023

Supplemental Materials and Methods. This file contains supplemental materials and methods.
Supplementary Figure 3 from PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia
Authors: McElwee John L. , Mohanan Sunish , Horibata Sachi , Sams Kelly L. , Anguish Lynne J. , McLean Dalton , Cvitaš Iva , Wakshlag Joseph J. , Coonrod Scott A.
Published: April 2023

Supplementary Figure 3: Expression of markers for inflammation and EMT across three tissues from MMTV-FLAG-PAD2 transgenic founder lines
Supplementary experimental procedures figure legends and references from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

Description of the supplementary experimental procedures figure legends and references
Supplementary Figure 3 from Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity
Authors: Browne Ashley , Tookman Laura A. , Ingemarsdotter Carin K. , Bouwman Russell D. , Pirlo Katrina , Wang Yaohe , McNeish Iain A. , Lockley Michelle
Published: April 2023

Female CD1nu/nu mice with intraperitoneal SKOV3ip1 tumours were injected IP with dl922-947 (10^10 particles). E1A immunohistochemistry was performed on all mice (three mice per time point) and E1A expression was scored by a pathologist who was blind to the experimental groups.
Supplementary Fig 7 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

Treatment of CAL51 cells with AZ3146 and NMS-P715 selected for the same p.S611G and p.Y568C MPS1 mutations.
Supplementary Figure 1 from Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity
Authors: Browne Ashley , Tookman Laura A. , Ingemarsdotter Carin K. , Bouwman Russell D. , Pirlo Katrina , Wang Yaohe , McNeish Iain A. , Lockley Michelle
Published: April 2023

SKOV3ip1 cells were infected in duplicate with dl922-947 (MOI 10 and MOI 100), Ad5 WT (MOI 10 and MOI 100) or vehicle. Cell supernatants were analysed for cytokine levels using the Mesoscale system at 3 hours and 6 hours post infection.
Supplementary Fig 5 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

Crystal structures of AZD3146 and ONCOII bound to MPS1-KD.
Supplementary Methods from Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
Authors: Kantara Carla , O'Connell Malaney , Sarkar Shubhashish , Moya Stephanie , Ullrich Robert , Singh Pomila
Published: April 2023

PDF file - 133KB
Supplementary Fig 1 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

Expression of the p.S611G, p.I531M and Dbl MPS1 mutant constructs in DLD1 Flp-In TRex cells recues the spindle assembly checkpoint defect following AZ3146 treatment.
Supplementary Figures S1-S6 from Tenascin-C Protects Cancer Stem–like Cells from Immune Surveillance by Arresting T-cell Activation
Authors: Jachetti Elena , Caputo Sara , Mazzoleni Stefania , Brambillasca Chiara Svetlana , Parigi Sara Martina , Grioni Matteo , Piras Ignazio Stefano , Restuccia Umberto , Calcinotto Arianna , Freschi Massimo , Bachi Angela , Galli Rossella , Bellone Matteo
Published: April 2023

Supplementary Figures S1-S6. Representative dot plots of in vitro inhibition of T cell activation by TPIN-SCs (S1); Non-irradiated TPIN-SCs arrest in vitro T cell activation (S2); TPIN-SCs inhibit restimulation of antigen-experienced T cells but do not affect fully activated T cells (S3); TPIN-SC-conditioned T cells are hyporesponsive (S4); Silencing of TNC modulates the inhibitory activity of TPIN-SCs (S5); CSCs migration is mediated by the CXCR4/CXCL12 axis (S6).
Supplementary Figure S6 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: April 2023

Supplementary Figure S6. Foretinib and MET knockdown inhibits proliferation, migration and invasion of medulloblastoma cells
Supplementary Figure S5 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: April 2023

Supplementary Figure S5. PDGFRÃƒ? pathway inhibition in foretinib treated Daoy and D425 medulloblastoma cells
Supplemental Methods, Figures 1 - 8, Tables 1 - 2 from RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
Authors: Zhao Xuesong , Ponomaryov Tatyana , Ornell Kimberly J. , Zhou Pengcheng , Dabral Sukriti K. , Pak Ekaterina , Li Wei , Atwood Scott X. , Whitson Ramon J. , Chang Anne Lynn S. , Li Jiang , Oro Anthony E. , Chan Jennifer A. , Kelleher Joseph F. , Segal Rosalind A.
Published: April 2023

Figure S1. Growth and survival of SMB cells depends on Shh signaling. Figure S2. SMB cell lines are a faithful model to study resistance to Smo inhibitors. Table S1. List of candidate genes with mutations used in the study. Figure S3. RAS signaling confers resistance to Smo inhibitor LDE225. Figure S4. FGF/RAS signaling abrogates dependence on Shh signaling. Figure S5. FGF/RAS-driven resistance to Smo inhibition is reversible and can be treated with MEK inhibitors. Figure S6. MEK inhibitors have therapeutic potential for HRAS SMB cells. Figure S7. Morphology of SMB(HRAS) cells differs from SMB parental cells. Figure S8. Immunohistochemistry of SFRP1, pERK and FGF in primary and metastatic samples from human Shh-subtype medulloblastoma patients. Table S2. Clinical diagnosis for human patient samples shown in Figure 5.
supplementary figure 6 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: April 2023

supplementary figure 6: differences in all types of stromal cell components in BMs among AML patients with different clinical courses.
Supplementary Figure Legends from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: April 2023

Supplementary Figure Legends. Contains the figure legends for supplementary figures 1S to 7S.
Supplementary Figure Legends from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: April 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S4.
Supplementary Table 3 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: April 2023

Primer sequences used for mRNA applification by qPCR.
Supplementary Table S2 from Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach
Authors: Cerasuolo Marianna , Paris Debora , Iannotti Fabio A. , Melck Dominique , Verde Roberta , Mazzarella Enrico , Motta Andrea , Ligresti Alessia
Published: April 2023

Supplementary Table S2. Parameter values used in the numerical simulations.
Supplementary Materials from Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Wilson Katheryne E. , Tian Lu , Lutz Amelie M. , Willmann Jürgen K.
Published: April 2023

Supplementary Table 1. Summary of B7-H3 Immunohistochemistry Scores in Human Tissue Samples. Supplementary Table 2. Subanalysis of B7-H3 IHC Scores in Cancer and Surrounding Normal, Benign and Precursor Lesions
Supplementary Figure S1 from Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach
Authors: Cerasuolo Marianna , Paris Debora , Iannotti Fabio A. , Melck Dominique , Verde Roberta , Mazzarella Enrico , Motta Andrea , Ligresti Alessia
Published: April 2023

Supplementary Figure S1. Non-linear regression of experimental data showing LNCaP cells differentiation rate at different androgen levels. Data fit obtained with the Ricker function.
Supplementary Table 1 from NF-κB: Regulation by Methylation
Authors: Lu Tao , Stark George R.
Published: April 2023

Methylation of NF-κB, genetic alteration of PRMT5 and hypothetical model.
Supplemental Figures S1-S6 from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor
Authors: Sahu Ravi P. , Ocana Jesus A. , Harrison Kathleen A. , Ferracini Matheus , Touloukian Christopher E. , Al-Hassani Mohammed , Sun Louis , Loesch Mathew , Murphy Robert C. , Althouse Sandra K. , Perkins Susan M. , Speicher Paul J. , Tyler Douglas S. , Konger Raymond L. , Travers Jeffrey B.
Published: April 2023

Supplemental Figures S1-S6
Supplementary Table S3 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: April 2023

Pharmacokinetic parameters of vemurafenib in Cyp3aKO/Cyp3a13+/+ and huCYP3A4/3A7 mice pre-treated with PCN.
Supplementary Table Legends from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: April 2023

Legend for Supplementary Tables S1-S7.
Supplementary Figure 6 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: April 2023

Supplementary Figure 6: CCL5 promotes MMP transcription in OCy. MLO-Y4 cells were plated and incubated for 24 hours to produce CM. Recombinant CCL5 was then incubated with MLO-Y4 for 5 hours prior to harvesting of mRNA. Real-time PCR was performed to investigate changes in MMP expression. One-way ANOVA with Bonferroni post-test was used for analysis. All bars represent significant relationships of p>0.05.
Supplemental Methods and References from Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer
Authors: Tesfay Lia , Clausen Kathryn A. , Kim Jin Woo , Hegde Poornima , Wang Xiaohong , Miller Lance D. , Deng Zhiyong , Blanchette Nicole , Arvedson Tara , Miranti Cindy K. , Babitt Jodie L. , Lin Herbert Y. , Peehl Donna M. , Torti Frank M. , Torti Suzy V.
Published: April 2023

Supplemental Methods and References. Description of additional methods and procedures used in the study. Also includes Supplemental References.
Supplementary Figure 2 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: April 2023

Supplementary Figure 2: MLO-Y4 CM promotes PCa viability, migration, and invasion. CM was isolated from MLO-Y4 cells. Viability of PCa cells after 24 hour incubation with MLO-Y4 CM as measured by resazurin. Student's two-tailed unpaired t-test was used to assess statistical differences; p<0.05. CM was also used as a chemoattractant in Boyden chamber assays to assess PCa migration and invasion. CM was compared to negative control (RPMI with 0.1% FBS) and positive control (RPMI with 10% FBS) media. One-way ANOVA with Bonferroni post-test used for analysis; bars represent significant differences where p<0.05.
Supplementary Figure S4 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: April 2023

Plasma and liver concentrations of sorafenib and SG in wildtype, Abcc3(-/-), Abcc4(-/-) and Abcc3;Abcc4(-/-) mice.
Supplementary Figure S6 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: April 2023

Supplementary Figure S6. Results of the flow cytometric analysis of indicated populations of leukocytes in spleen (A) and bone marrow (B) of C57Bl/6 mice bearing B16F0 melanoma tumors.
Supplementary Figure S3 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: April 2023

Supplementary Figure S3. (-)-Nutlin-3 and MLN8237 cooperate in p53 induction in vivo.
Supplementary Figure S1 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: April 2023

Supplementary Figure S1. The hybrid physiologically-based pharmacokinetic models for (-)-Nutlin-3 and MLN8237 comprising several organ compartments.
Supplementary Figure 3 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: April 2023

Activation and functional response of Cetux-CAR+ and Nimo-CAR+ T cells in response to cell lines with varying endogenous EGFR expression
Supplementary Table S5: Mass spectrometry lipidomics data from Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Authors: Southam Andrew D. , Khanim Farhat L. , Hayden Rachel E. , Constantinou Julia K. , Koczula Katarzyna M. , Michell Robert H. , Viant Mark R. , Drayson Mark T. , Bunce Chris M.
Published: April 2023

Negative ion mass spectrometry (phospholipid) analysis of lipid extracts from HL60 and K562 cells after 24 hr BaP treatment (0.5 mM bezafibrate, BEZ, and 5 µM medroxyprogesterone acetate, MPA).
Suppl Table S6 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: April 2023

Suppl Table S6. MVA of miR-138 activity signature
Supplementary Figure S1 from HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Authors: Azoitei Ninel , Diepold Kristina , Brunner Cornelia , Rouhi Arefeh , Genze Felicitas , Becher Alexander , Kestler Hans , van Lint Johan , Chiosis Gabriela , Koren John , Fröhling Stefan , Scholl Claudia , Seufferlein Thomas
Published: April 2023

Supplementary Figure S1. HSP90 silencing results in augmented apoptosis.
Supplementary Figure 8 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer
Authors: Simó-Riudalbas Laia , Pérez-Salvia Montserrat , Setien Fernando , Villanueva Alberto , Moutinho Catia , Martínez-Cardús Anna , Moran Sebastian , Berdasco Maria , Gomez Antonio , Vidal Enrique , Soler Marta , Heyn Holger , Vaquero Alejandro , de la Torre Carolina , Barceló-Batllori Silvia , Vidal August , Roz Luca , Pastorino Ugo , Szakszon Katalin , Borck Guntram , Moura Conceição S. , Carneiro Fátima , Zondervan Ilse , Savola Suvi , Iwakawa Reika , Kohno Takashi , Yokota Jun , Esteller Manel
Published: April 2023

Supplementary Figure 8. Effect of KAT6B shRNA-mediated depletion in ATM expression and H2AX phosphorylation
Supplementary Figure S2 from Early Prediction of Disease Progression in Small Cell Lung Cancer: Toward Model-Based Personalized Medicine in Oncology
Authors: Buil-Bruna Núria , Sahota Tarjinder , López-Picazo José-María , Moreno-Jiménez Marta , Martín-Algarra Salvador , Ribba Benjamin , Trocóniz Iñaki F.
Published: April 2023

Schematic view of the biomarker model and differential equations used to describe the model. Briefly, DISEASE is a latent variable that represents disease progression and drives LDH and NSE production. RT (radiotherapy) and CT (chemotherapy) each affect disease level, where CT decreases its value and RT slows its linear growth. Resistance (REST) is modeled by linking cumulative exposure with a decrease in the drug effect. G-CSF (granulocyte colony-stimulating factor) increases the physiological LDH synthesis.
Supplementary Figure Legends S1 - S3 from Early Prediction of Disease Progression in Small Cell Lung Cancer: Toward Model-Based Personalized Medicine in Oncology
Authors: Buil-Bruna Núria , Sahota Tarjinder , López-Picazo José-María , Moreno-Jiménez Marta , Martín-Algarra Salvador , Ribba Benjamin , Trocóniz Iñaki F.
Published: April 2023

Legends for supplementary Figures S1, S2 and S3
Supplemental Figure 1 from Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding
Authors: Goldstein Michael , Kastan Michael B.
Published: April 2023

Figure S1. PARP1 and ATM inhibition attenuates Brca1 recruitment in the DSB surrounding regions but not directly at the DSB
Supplementary Table 1, Figures 1-5 from Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice
Authors: Liu Xiaojun , Jiang Shuguang , Fang Chongyun , Yang Shiyu , Olalere Devvora , Pequignot Edward C. , Cogdill Alexandria P. , Li Na , Ramones Melissa , Granda Brian , Zhou Li , Loew Andreas , Young Regina M. , June Carl H. , Zhao Yangbing
Published: April 2023

Supplementary Table 1, Figures 1-5. Supplemental Table 1 (Table S1) - Affinity of a bivalent antibody (IgG KD) is largely different from it monovalent form (scFv KD). Supplemental Figure 1 (Fig. S1) - Surface expression level of ErbB2 detected by flow cytometry is correlated with mRNA level detected by quantitative PCR. Supplemental Figure 2 (Fig. S2) - CD107a up-regulation was different between higher affinity ErbB2 CART cells and lower affinity CART cells when stimulated with tumor cell lines expressing ErbB2 at different levels. Supplemental Figure 3 (Fig. S3) - More tumor cell lines tested in a CD107a assay confirmed that lower affinity ErbB2 CART cells only recognized ErbB2 over expression tumors. Supplemental Figure 4 (Fig. S4) - ErbB2 target dependent upregulation of CD107a of lower affinity ErbB2 CAR lentiviral transduced, as well as lower affinity ErbB2 CAR mRNA electroporated T cells. Supplemental Figure 5 (Fig. S5) - ErbB2 CART cells with decreased affinity controlled tumor growth as efficiently as ErbB2 CART cells with higher affinity.
Supplementary Tables S1-S3 from Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma
Authors: Soroceanu Liliana , Matlaf Lisa , Khan Sabeena , Akhavan Armin , Singer Eric , Bezrookove Vladimir , Decker Stacy , Ghanny Saleena , Hadaczek Piotr , Bengtsson Henrik , Ohlfest John , Luciani-Torres Maria-Gloria , Harkins Lualhati , Perry Arie , Guo Hong , Soteropoulos Patricia , Cobbs Charles S.
Published: April 2023

Detection of HCMV and cellular markers in 40 patient samples included in this study (S1); HCMV serostatus in a subset of GBM cases (S2); Histopathological and immunohistochemical characterization of spontaneous mouse gliomas (S3).
Supplementary Table 1 and Supplementary Figures 1 through 7 from Tetraspanin CD81 Promotes Tumor Growth and Metastasis by Modulating the Functions of T Regulatory and Myeloid-Derived Suppressor Cells
Authors: Vences-Catalán Felipe , Rajapaksa Ranjani , Srivastava Minu K. , Marabelle Aurelien , Kuo Chiung-Chi , Levy Ronald , Levy Shoshana
Published: April 2023

Supplementary Table 1: Antibodies used in this study. Supplementary Figure 1: CD81 expression on tumor cell lines. Supplementary Figure 2: Analysis of purified CD4+CD25+ Tregs for FoxP3 expression. Supplementary Figure 3: Tregs from LLC and E0771 tumor bearing CD81KO C57BL6 mice are less suppressive. Supplementary Figure 4: Naive BALB/c WT or CD81 KO T CD4+ cells are equally suppressed by WT, HT or CD81 KO Tregs. Supplementary Figure 5: Analysis of the indicated proteins (A) and mRNA (B) expression in purified WT or CD81KO MDSCs. Supplementary Figure 6: Analysis of ROS levels measured in MDSCs and Lymphocytes in WT, HT or CD81KO C57BL/6 mice. Supplementary Figure 7: WT and CD81KO Tregs express similar levels of the indicated markers.
Supplementary Figure Legends from Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma
Authors: Soroceanu Liliana , Matlaf Lisa , Khan Sabeena , Akhavan Armin , Singer Eric , Bezrookove Vladimir , Decker Stacy , Ghanny Saleena , Hadaczek Piotr , Bengtsson Henrik , Ohlfest John , Luciani-Torres Maria-Gloria , Harkins Lualhati , Perry Arie , Guo Hong , Soteropoulos Patricia , Cobbs Charles S.
Published: April 2023

Legend for Supplementary Figures S1-S10.
Supplemental Table S2 from A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer
Authors: Kim Jong-Eun , Son Joe Eun , Jeong Hyein , Kim Dong Joon , Seo Sang Gwon , Lee Eunjung , Lim Tae Gyu , Kim Jong Rhan , Kimbung Yengo Raymond , Chen Hanyong , Bode Ann M. , Lee Ki Won , Dong Zigang
Published: April 2023

Supplemental Table S2. Kinase screening of 2'hydroxycinnamicaldehye (20 μM).
Supplemental Figure S1 from A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer
Authors: Kim Jong-Eun , Son Joe Eun , Jeong Hyein , Kim Dong Joon , Seo Sang Gwon , Lee Eunjung , Lim Tae Gyu , Kim Jong Rhan , Kimbung Yengo Raymond , Chen Hanyong , Bode Ann M. , Lee Ki Won , Dong Zigang
Published: April 2023

Supplemental Figure S1. 2'-HCA does not exert significant effects on (A,B) body weight or (C) liver status in mice.
Supplemental Figure S5 from Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGFβ-Activating miR424–503 Gene Cluster
Authors: Li Yun , Li Wei , Ying Zhe , Tian Han , Zhu Xun , Li Jun , Li Mengfeng
Published: April 2023

Supplemental Figure S5. miR-424-503 cluster enhances TGF-β signaling activity.
Supplementary Figure S5 from Tracking and Functional Characterization of Epithelial–Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis
Authors: Ruscetti Marcus , Quach Bill , Dadashian Eman L. , Mulholland David J. , Wu Hong
Published: April 2023

Supplementary Figure S5. Epithelial and EMT-like tumor cells form macrometastases with epithelial features, while mesenchymal tumor cells exist as quiescent solitary cells in the lungs.
Supplementary Figure S3 from Tracking and Functional Characterization of Epithelial–Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis
Authors: Ruscetti Marcus , Quach Bill , Dadashian Eman L. , Mulholland David J. , Wu Hong
Published: April 2023

Supplementary Figure S3. EMT-like and mesenchymal tumor cells have enhanced tumor-initiating capacity in vivo.
Supplemental Figure S1 from Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGFβ-Activating miR424–503 Gene Cluster
Authors: Li Yun , Li Wei , Ying Zhe , Tian Han , Zhu Xun , Li Jun , Li Mengfeng
Published: April 2023

Supplemental Figure S1. Relative expression of miR-424 was plotted against expression of miR-503 in breast cancer cell lines and breast cancer tissues.
Supplementary Figure Legends from Tracking and Functional Characterization of Epithelial–Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis
Authors: Ruscetti Marcus , Quach Bill , Dadashian Eman L. , Mulholland David J. , Wu Hong
Published: April 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S5.
Supplemental Table 2 from KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine
Authors: Stewart Michelle L. , Tamayo Pablo , Wilson Andrew J. , Wang Stephanie , Chang Yun Min , Kim Jong W. , Khabele Dineo , Shamji Alykhan F. , Schreiber Stuart L.
Published: April 2023

The differential mutual information score (Ic, methods) is used in this table to correlate pathways with activity of decitabine in solid tumor cell lines.
Supplementary Table and Figure Legends from A Molecular Portrait of High-Grade Ductal Carcinoma In Situ
Authors: Abba Martin C. , Gong Ting , Lu Yue , Lee Jaeho , Zhong Yi , Lacunza Ezequiel , Butti Matias , Takata Yoko , Gaddis Sally , Shen Jianjun , Estecio Marcos R. , Sahin Aysegul A. , Aldaz C. Marcelo
Published: April 2023

Supplementary Table and Figure Legends: Legend for Supplementary Tables S1-S5 and Supplementary Figures S1-S4.
Supplementary Table S3 from A Molecular Portrait of High-Grade Ductal Carcinoma In Situ
Authors: Abba Martin C. , Gong Ting , Lu Yue , Lee Jaeho , Zhong Yi , Lacunza Ezequiel , Butti Matias , Takata Yoko , Gaddis Sally , Shen Jianjun , Estecio Marcos R. , Sahin Aysegul A. , Aldaz C. Marcelo
Published: April 2023

Supplementary Table S3: Differentially expressed transcripts and PARADIGM inferences of the top 300 most variable integrated pathway activities between normal and DCIS samples.
Supplemental Figure S3 from KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine
Authors: Stewart Michelle L. , Tamayo Pablo , Wilson Andrew J. , Wang Stephanie , Chang Yun Min , Kim Jong W. , Khabele Dineo , Shamji Alykhan F. , Schreiber Stuart L.
Published: April 2023

A, cell viability after treatment with decitabine (AUC, x-axis) was plotted against DNMT3a or DNMT3b mRNA expression (log2, y-axis). B, western blot analysis was performed after treatment with decitabine (0.5 ÃŽÂ¼M) or DMSO for nine days in eight ovarian cancer cell lines. C, quantification of western blot analysis of DNMT1 after treatment with selumetinib for six days in two KRAS-mutant ovarian cancer cell lines as depicted in the main text.
Supplementary Materials and Methods from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling
Authors: Moutal Aubin , Honnorat Jérôme , Massoma Patrick , Désormeaux Pauline , Bertrand Caroline , Malleval Céline , Watrin Chantal , Chounlamountri Naura , Mayeur Marie-Eve , Besançon Roger , Naudet Nicolas , Magadoux Léa , Khanna Rajesh , Ducray François , Meyronet David , Thomasset Nicole
Published: April 2023

Supplementary Materials and Methods
Supplementary Methods from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplemental Figure S6 from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling
Authors: Moutal Aubin , Honnorat Jérôme , Massoma Patrick , Désormeaux Pauline , Bertrand Caroline , Malleval Céline , Watrin Chantal , Chounlamountri Naura , Mayeur Marie-Eve , Besançon Roger , Naudet Nicolas , Magadoux Léa , Khanna Rajesh , Ducray François , Meyronet David , Thomasset Nicole
Published: April 2023

CRMP5 does not modulate Notch ligand expression. Western blot analysis of three Notch ligands-Jagged 1, DLL1 and DNER-using specific antibodies after CRMP5 silencing; representative western blots of three independent experiments are shown.
Supplemental Figure S4 from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling
Authors: Moutal Aubin , Honnorat Jérôme , Massoma Patrick , Désormeaux Pauline , Bertrand Caroline , Malleval Céline , Watrin Chantal , Chounlamountri Naura , Mayeur Marie-Eve , Besançon Roger , Naudet Nicolas , Magadoux Léa , Khanna Rajesh , Ducray François , Meyronet David , Thomasset Nicole
Published: April 2023

CRMP5 depletion does not promote apoptosis.(A): Apoptosis is monitored in GL15 cells transfected with CRMP5-siRNA1 and control-siRNA using caspase 3 antibody (1/400, BD Pharmingen, 559565). 5-bromo-2'-deoxyuridine (BrdU) indicates proliferating cells in both conditions. (B): TUNEL staining (marker of apoptosis) (Promega, G3250) in CRMP5-siRNA1 transfected GL15 cells Scale bar=20µm. (C): TUNEL staining quantification in CRMP5-siRNA transfected GL15 cells after 4 days. The total number of cells counted is indicated by DAPI quantification; TUNEL-stained cells were counted for each condition. The results were obtained from 3 independent experiments.
Supplementary Figure S5 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Figure S5. Phospho-STAT3 (Y705) staining in tumor xenografts.
Supplementary Figure S1 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Figure S1. Effect of G-CSF on neuroblastoma subpopulations.
Supplementary Dataset 2 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

Metabolomics dataset
Supplementary Dataset 1 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

Metabolomics dataset
Supplementary Figure S6 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Authors: Marchiq Ibtissam , Le Floch Renaud , Roux Danièle , Simon Marie-Pierre , Pouyssegur Jacques
Published: April 2023

Figure S6: Phenformin/MCT1 inhibition induces an increase in the ROS content and ROS scavengers do not rescue cell death.
Supplementary Table 2 from Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
Authors: Zhang Shubing , Chung Wen-Cheng , Wu Guanming , Egan Sean E. , Miele Lucio , Xu Keli
Published: April 2023

Supplementary Table 2. Correlation studies between MFNG, NOTCH4 and PIK3CG gene expressions using 6 independent data sets
Supplementary Figure 4 from Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
Authors: Zhang Shubing , Chung Wen-Cheng , Wu Guanming , Egan Sean E. , Miele Lucio , Xu Keli
Published: April 2023

Supplementary Figure 4. Pharmacological inhibition of PI3Kγ has no effect on proliferation of MDA-MB231 cells, but shows an inhibitory effect on C0321 cells.
Supplementary Table S2 from IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden
Authors: van der Zee Marten , Sacchetti Andrea , Cansoy Medine , Joosten Rosalie , Teeuwssen Miriam , Heijmans-Antonissen Claudia , Ewing-Graham Patricia C. , Burger Curt W. , Blok Leen J. , Fodde Riccardo
Published: April 2023

Supplementary Table S2. Summary of serial transplantation assays of primary endometrial cancer cells.
Supplementary Figure 3 from Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
Authors: Zhang Shubing , Chung Wen-Cheng , Wu Guanming , Egan Sean E. , Miele Lucio , Xu Keli
Published: April 2023

Supplementary Figure 3. A reactome functional interaction network for genes that are differentially expressed in xenografts of shMFNG and control MDA-MB231 cells
Supplementary Figures 1-9 from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Authors: Klingler Stefan , Guo Baofeng , Yao Jun , Yan Haiyan , Zhang Ling , Vaseva Angelina V. , Chen Sida , Canoll Peter , Horner James W. , Wang Y. Alan , Paik Ji-Hye , Ying Haoqiang , Zheng Hongwu
Published: April 2023

Supplementary Figures 1-9. Figure S1: Auto-phosphorylation of EGFR-A289V and EGFR-G598V can be inhibited by EGFR TKIs. Figure S2: EGFR* expression is strongly induced in hGFAP-tTA tetO-EGFR* off-Dox mouse brains. Figure S3: Gfap and Nestin protein expression are overlapped in a subpopulation of NPCs. Figure S4: Representative H&E images of a Grade IV malignant glioma. Figure S5: Malignant glioma cells do not express terminally differentiated CNS cell lineage markers. Figure S6: iEIP glioma subcutaneous transplants are sensitive to genetic suppression of EGFR* induction but not to EGFR TKI. Figure S7: iEIP gliomas are sensitive to acute EGFR* ablation. Figure S8: Ingenuity pathway analysis comparing gene expression profiling of untreated control tumors with Dox-treated relapsed tumors. Figure S9: Combined treatment of Dox and Bez-235 inhibits EGFR* induction and Akt activation.
Supplementary Figure S1 from IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden
Authors: van der Zee Marten , Sacchetti Andrea , Cansoy Medine , Joosten Rosalie , Teeuwssen Miriam , Heijmans-Antonissen Claudia , Ewing-Graham Patricia C. , Burger Curt W. , Blok Leen J. , Fodde Riccardo
Published: April 2023

Supplementary Figure S1. Quantitative real-time PCR analysis of the expression of EMT markers.