bluuebunny/crossref_metadata_2025 huggingface dataset:
Profile of Newly Referred Glaucoma Patients to the Largest Tertiary Eye Care Hospital in Saudi Arabia
Authors: Jomar Deema , Alhomoud Abdulrahman , AlObaida Ibrahim , AlSobaie Nasser , Helmi Hala , Ahmad Khabir , Owaidhah Ohoud , Schargel Konrad
Published: January 2023

Purpose: To report the profile of newly referred glaucoma patients to the largest tertiary eye care hospital in Saudi Arabia.
Patients and Methods: Medical records of all Saudi nationals who presented with glaucoma to the Glaucoma Clinics at King Khaled Eye Specialist Hospital (KKESH) as a first visit through the Eligibility Department, Screening Clinic or Emergency Department between March 2019 and August 2019 were reviewed. Patients underwent a comprehensive glaucoma workup and a detailed documentation of their demographics, clinical exam findings, type and stage of glaucoma at presentation along with previous and offered management. Upon presentation, the stage of glaucoma was compared between eyes with primary glaucoma including primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG) and eyes with Secondary glaucoma.
Results: A total of 532 patients newly presented to KKESH during the study period. The median (interquartile [IQR] range) age of the patients was 63 (17) years, 47.9% of the patients were female. The majority of referred cases came from Riyadh (46.6%), Najran (9.8%) and AlQassim (9.4%) provinces. PACG was the most predominant form of glaucoma (30.5%), followed by POAG. Pseudoexfoliation glaucoma (PSXG) and neovascular glaucoma (NVG) were the most common subtypes among secondary glaucoma. Two out of every five eyes presenting with glaucoma (41.5%) had severe disease.
Conclusion: In this tertiary setting, PACG was the most commonly encountered glaucoma. A significant proportion of the patients, particularly those with POAG (“the silent thief of sight”) presented with an advanced disease. To limit the irreversible visual loss and socio-economic burden of glaucoma, a large community-based study is required to look into the epidemiology of glaucoma among all Saudi provinces followed by the implementation of a national screening and intervention program.
Content and style transfer with generative adversarial network
Authors: Ding Wenhua , Du Junwei , Hou Lei , Liu Jinhuan
Published: January 2023

The generative adversarial network is often used for image conversion tasks such as image coloring, semantic composition,style transfer, etc.,but at this stage, the training of image generation models often depends on a large number of paired datasets, and can only achieve conversion between two image domains.When processing tasks in more than two domains,it lacks scalability and robustness.To solve the above problems,this paper proposes a Content and Style transfer model based on Generative Adversarial Network (CS-GAN).This model can fuse style features (such as monet style,cubism) and content features (such as color ,texture) of fashion items on unpaired datasets at the same time,which can realize the conversion of multiple image domains,so as to effectively complete the task of transferring the content and style of fashion items.In particular,we propose a layer consistent dynamic convolution (LCDC) method,which encodes the style image as a learnable convolution parameter,which can adaptively learn style features,and more flexibly and efficiently complete the arbitrary style transfer of fashion items.To validate the performance of our model,we conducts comparative experiments and results analysis on the public fashion dataset. Compared with other mainstream methods,this method has improved in image synthesis quality,Inception Score (IS) and Frechet Inception Dinstance score (FID) evaluation index.
Diversity and functional prediction of fungal communities in different segments of Mongolian horse gastrointestinal tracts
Authors: Zhao Yiping , Wu Haiqing , Hu He , Cheng Chao , Du Ming , Huang Yao , Zhao Xiaoqing , Wang Liwei , Yi Liuxi , Tao Jinshan , Li Yajing , Lin Yanan , Su Shaofeng , Dugarjaviin Manglai
Published: January 2023

Background: Anaerobic fungi are effective fiber degrading microorganisms in the digestive tract of horses, but thus far, our understanding of their diversity and community structure is limited, especially the distribution of different parts of the gastrointestinal tract is practicallyt blank.
Results: For the first time, high-throughput sequencing technology was used to analyze and predict the fungal microbial diversity in the contents of different parts of gastrointestinal tract of Mongolian horse. The results showed that the richness and diversity of fungi in the hindgut of Mongolian horses were much higher than those in the foregut. The foregut was dominated by Basidiomycota and Ascomycota, while the hindgut was dominated by Neocallimastigomycota and Basidiomycota. At the genus level, the relative abundance of a large number of pathogenic fungi (Cryptococcus, Cladosporium, Alternaria, Sarocladium and Fusarium) in the foregut was significantly higher than that in the posterior gut (P <0.01 or P <0.05), indicating that Mongolian horses had strong disease resistance. The prediction of fungal function also showed that there were significant differences in the fungal flora between the foregut and the hindgut. The fungi in the foregut of Mongolian horses are mainly pathologically nutritive and contain a large number of animal and plant pathogens, especially in the small intestine (jejunum and ileum), indicating that the foregut may be the most important immune site in the digestive system of Mongolian horses, which well explains the high disease resistance of Mongolian horses. The Unassigned functional group in the posterior gut is significantly higher than that in the anterior gut, indicating that the functions of fungal groups in the posterior gut have not been fully explored and further study is needed in the future.
Conclusions: The study of the fungal diversity of the Mongolian horse health digestive system provides important basic data, can be used for the Mongolian horse health assessment, and for further study on the horse of the digestive system, horse disease resistance, and even the development of microbial supplements provide clues.
Prevalence of Mud crab reovirus (MCRV) in open pen and cage aquaculture system
Authors: Nivas Naveen , Gopalakrishnan Ayyaru , Kaippilly Dinesh , Srav Savva , John Anisha Shafni , Dayalane Saranya , Dhasarathan Balu
Published: January 2023

Mud crab farms along the east coast of India have been facing mysterious mass mortality for the past few years. Recently, Mud crab reovirus was found to be responsible for this mortality in the east coast of India. This study investigated the mortality rate of mud crabs raised in an open-pen and cage environment in relation to mud crab reovirus infection. The crabs were cultured in open pens, cages within the pens, and cages outside the pens i-e in open water without any enclosures. The dead and moribund crabs were tested for etiological agents responsible for the mortality using histopathology, TEM and RTPCR. The mortality rate in the open pen culture system was found to be 73 ± 4.57%, whereas the mortality rate in cages inside the pen was found to be 18 ± 2.21%, and in cages outside the pen in open water was found to be 17.3%. Mud crab cannibalistic behavior was found to be the primary rationale for the higher MCRV transmission rate in open pens where the crabs are not separated, contrary to the cage culture technique. The present study revealed that rearing mud crabs in cage crabs in individual cages decreases the mortality rate of mud crabs up to 20 percent. Therefore, fattening or culturing mud crabs in cages benefits farmers with higher survival rates and economic performance.
Pharmaceutical Residues Removal in Two- and Three-Dimensional Electrochemical Process by Orange Peels as a Third Electrode
Authors: Kindi Ghayda Al , Al-Haidri Husam
Published: January 2023

Pharmaceutical waste is considered an environmental burden, due to its incomplete treatment in traditional treatment plants, so the aim of this study was to remove tetracycline in a two- and three-dimensional electrochemical system, using nano zerovalent Iron (nZVI) prepared from orange peel extract after fixing it with CMC as third granular electrodes. The using of Fourier instrument infrared (FTIR), Bruneian-Emmett-Teller (BET) surface area analysis. Electron microscopy (SEM) and energy dispersive spectroscopy (EDS) to study the physical and chemical properties of nZVI, the electrochemical system consists of graphite anode and stainless steel as cathode, with The use of several parameters in different values such as reaction time, pH, tetracycline concentration, and current density . From the results it was found that the efficiency of the three-dimensional electrochemical system is more than the two-dimensional in the removal of tetracycline, it was found that the removal efficiency is 99% for the 3D system while 78% for the 2D system. The optimal operating conditions for the 3D were pH 4.5, reaction time 30 min, 0.25 g/L Na2SO4, current density 40 mA/cm2, and tetracycline concentration 160 mg/L. While for 2D, the were pH 5.5, the reaction time 40 minutes, current density 50 mA/cm2, and the concentration of tetracycline 160 mg/L. .so that, 3D electrochemical process is an innovative alternative with excellent efficiency of removing tetracycline from the wastewater.
Improving Healthcare system in Saudi Arabia from Healthcare aspect using qualitative methods
Authors: Alshammari Abdullah R , Alshammari Rakan , Alshammary Muharib
Published: January 2023

Aim
Exploring healthcare provider attuited to improve the primary health care (PHC) from their aspect.
Methods
Qualitative study; semi-structured interview were utilised method. purposive sampling adopted. Target sample were health services administrators of in Ha’il city. Thematic analysis was adopted in this study.
Results
Totally of 7 participants; 4 male and 3 females were all of them have the same socioeconomic status. Four main themes appear which were: workforce training, sharing responsibility with workforce, input technology and improve the attitudes of healthcare visitors.
Conclusion
There is demand and welling to improve the healthcare services, that can be achieved by the help of the visitors of the healthcare services, professional training of the healthcare workforce and include the new technology within the healthcare setting.
Research on the coupling force between the grinding wheel and rail in grinding train system
Authors: Liu Tao , Cui Dabin , Fu Yaodong , Liu Zhanghong , Li Li
Published: January 2023

During the grinding train operation process, the grinding force between the grinding wheel and the rail is critical in ensuring the grinding quality and efficiency. The coupling vibration among the frame, the grinding wheels and the wheelsets will seriously affect the stability of the grinding force. In this paper, the coupled mechanical model of the grinding wheel/rail is established based on the contact mechanics theory, which is embedded as a submodel into the dynamic model of the multi-rigid buggy. The interaction among the frame, the grinding wheels, and the wheelsets are analyzed by setting the convex irregularity on the rail. The grinding effect is evaluated in combination with the subway’s long wave corrugation grinding conditions. The results show that when the grinding buggy passes the convex irregularity, the vibration excited by the wheelset system has a significant impact on the dynamic behavior of the grinding wheels. The vibration of the grinding wheel is mainly transmitted between the grinding wheel and the frame, less affecting the wheelset. For the long wave corrugation of the subway, the grinding effect of the grinding wheel has a certain correlation with the phase angle of the wheelset through the corrugation. The research results provide an important reference for the setting of the grinding pattern.
Soil-dwelling Antagonistic Streptomycetes; Isolation coupled with functional and molecular screening
Authors: Fathollahi-Dehkordi Farshid , Moshafi Mohammad Hassan , Illaghi-Hoseini Sahar , Nooshadokht Maryam , Raiesi Omid , Amirheidari Bagher
Published: January 2023

One of the most challenging medical concerns is treating diseases caused by resistant bacteria. It is hence inevitable to explore sources of new antimicrobial derivatives. Calcium dependent antibiotics (CDAs) are lipopeptide antibiotics produced by Streptomycetes. CDAs are synthesized by a genes cluster which includes many pathway-specific regulatory genes. The gene cdaR can be utilized as a marker of CDA production. Micrococcus luteus has been employed as indicator to probe the production of lipopeptide antibiotics. This study was designed to yield domestic soil bacteria capable of producing antibacterial products and probe whether they are of lipopeptide nature. Soil samples were collected from Baft County, southern Iran. Chalky appearance of colonies on a semi-differentiative solid medium, FZmsn, was used to isolate representative Streptomycetes. Genomic DNA of isolates was extracted utilizing RIMA ® Kit and PCR products were run on gel electrophoresis and visualized by ethidium bromide under UV light. Molecular identity of the isolates was probed by PCR using a Streptomyces-specific primer pair. Evaluation of the isolates’ antibacterial effects against six indicator bacteria was carried out by using a pen-assay cross-streak culture method. The isolates were also investigated for the presence of the regulatory gene cdaR. Twelve illustrative Streptomycetes were isolated and characterized. Pen-assay experiments resulted in four isolates effective against S. aureus, S. epidermidis, and B. subtilis. Three of these were antagonistic against E. coli and two against M. luteus. No isolate was found to counter the growth of P. aeruginosa. The method proved to be facile in yielding domestic Streptomycetes active against pathogenic bacteria. Further research is being done on the isolates and properties of their products.
Relativistic Mass of Spinning Black Holes in XRBs
Authors: Mahto Dipo
Published: January 2023

The present work provides a model for the relativistic mass of spinning black holes by using the model for black hole mass estimation (M = rv2/G) and the model for variation of universal constant(G) with spinning velocity of black holes in the strong gravitational field as proposed by Mahto et al. and calculates their values for XRBs black holes and concludes to justify the special relativity as well as model for variation of gravitational constant in the strong gravitational field as proposed by Mahto et al.(2013).
Outbreaks of cockchafers – how do genetic population structures of Melolontha melolontha and M. hippocastani differ?
Authors: Niemczyk Marzena , Tereba Anna , Skrzecz Iwona , Kajtoch Łukasz
Published: January 2023

CockchafersMelolonthaspp. are polyphagous root pests and outbreak species of considerable economic importance to forestry in Europe. However, knowledge about genetic diversity among and between populations of cockchafers is far from sufficient. In this study, we fill several gaps in the knowledge of genetic population structure and the intensity of gene flow betweenMelolontha melolontha(Mm) andM. hippocastani(Mh). Specifically, we used microsatellite markers of 421 imagines from three main outbreak areas in Poland. Our study revealed some differences in polymorphism and population structuration between the two species.Mmwas characterized by higher polymorphism and some evidence of population structure, whileMhdid not show population structuring, which may indicate that these two species have undergone different historical events. It is likely that onlyMmexperienced a reduction in population size but both species currently have high effective population sizes - likely as a result of an ongoing outbreak. A number of ~ 10 migrants per generation allows gene flow and maintains equilibrium in the population. Our study also revealed some important differences in migratory behavior between the sexes, with male cockchafers making more frequent long-distance flights. Current ecological and anthropogenic changes that alter the quantity and quality of the food base appear to favor the fecundity, development and dispersal of cockchafers. Our study adds cockchafers to the list of outbreak species with available genetic information. This information can be an important component of effective management strategies and a foundation for understanding and predicting the evolution of these species.
Workflow scheduling strategy based on deep reinforcement learning
Authors: ZHANG Shuo , Zhao Zhuofeng
Published: January 2023

With the increase of Internet of Things devices, the data intensive workflow has emerged. Because the data-intensive workflow has the characteristics of scattered data sources, large data scale and collaborative distributed execution at the cloud edge. It brings many challenges to the execution of workflow, such as data flow control management, data transmission scheduling, etc. Aiming at the execution constraints and data transmission optimization of data-intensive workflow, this paper proposes a workflow scheduling method based on deep reinforcement learning. First, the execution constraints, edge node load and data transmission volume of IoT data workflow are modeled; Then the data - intensive workflow is segmented with the optimization goal of data transmission; Besides, taking the workflow execution time and average load balancing as the optimization goal, the improved DQN algorithm is used to schedule the workflow. Based on the DQN algorithm, the model reward function and action selection are redesigned and improved. The simulation results based on WorkflowSim show that, compared with MOPSO, NSGA-II and GTBGA, the algorithm proposed in this paper can effectively reduce the execution time of IoT data workflow under the condition of ensuring the execution constraints and load balancing of edge nodes.
The Needs and Opportunities for Housing Improvement as a Malaria Intervention in Southern Tanzania
Authors: Bofu Ramadhani M. , Santos Ellen M. , John Betwel , Kahamba Najat , Swilla Joseph , Njalambaha Rukiyah , Kelly Ann H. , Lezaun Javier , Christofides Nicola , Okumu Fredros O. , Finda Marceline F.
Published: January 2023

Background
Malaria disproportionately affects low-income households in rural communities where poor housing is common. Despite evidence that well-constructed and mosquito-proofed houses can reduce malaria risk, housing improvement is rarely included in malaria control toolboxes. This study assessed the need, magnitude, and opportunities for housing improvement to control malaria in rural Tanzania.
Methods
A mixed-methods study was conducted in 19 villages across four district councils in southern Tanzania. A structured survey was administered to 1,292 community members to assess need, perceptions, and opportunities for housing improvement for malaria control. Direct observations of 802 houses and surrounding environments were done to identify the actual needs and opportunities, and to validate the survey findings. A market survey was done to assess availability and cost of resources and services necessary for mosquito-proofing homes. Focus group discussions were conducted with key stakeholders to explore insights on the potential and challenges of housing improvement as a malaria intervention.
Results
Compared to other methods for malaria control, housing improvement was among the best understood and most preferred by community members. Of the 735 survey respondents who needed housing improvements, a majority needed window screening (91.1%), repairs of holes in walls (79.4%), door covers (41.6%), closing of eave spaces (31.2%) and better roofs (19.0%). Community members invested significant efforts to improve their own homes against malaria and other dangers, but these efforts were often slow and delayed due to high costs and limited household incomes. Study participants suggested several mechanisms of support to improve their homes, including government loans and subsidies.
Conclusion
Addressing the need for housing improvement is a critical component of malaria control efforts in southern Tanzania. In this study, a majority of the community members surveyed needed modest modifications and had plans to work on those modifications. Without additional support, their efforts were however generally slow; households would take years to sufficiently mosquito-proof their houses. It is therefore crucial to bring together the key players across sectors to reduce barriers in malaria-proofing housing in endemic settings. These may include government subsidies or partnerships with businesses to make housing improvement more accessible and affordable to residents.
Determinants of the interval to brain metastasis from initial breast cancer diagnosis and its relation to survival: a single-center retrospective cohort
Authors: Orrego-González Eduardo , Nayar Varun , Moore Justin M , Vega Rafael A
Published: January 2023

Background: Brain metastasis (BM) carry short-term survival and a poor prognosis. Short-onset time to BM can lead to better survival than patients with delayed diagnosis. We intend to assess clinical factors associated with mortality and time to brain metastasis.
Methods:We retrospectively reviewed the charts of 113 patients in our institution who developed BM from primary breast cancer from 2000-2020. Demographic and clinical characteristics were reviewed. One-hundred-thirteen patients were eligible for survival analysis by univariate and multivariate COX regression. In addition, we performed statistical analysis to determine factors associated with undergoing surgery.
Results: Post-menopausal state at initial breast cancer (HR=1.66; CI 1.11-2.47, P=0.01), other ethnicities (HR=2.18; CI 1.17-4.04, P=0.01), and the subtype ER+/HER2+ (HR=2.13; CI 1.21-3.73, P=<0.05) were found on multivariate analysis to have a shorter interval to BM. Subgroup analysis of patients with ER+ tumors found that initial Stage IV at diagnosis (HR=1.83; CI 1.1-3.18, P=0.03) and HER2+ status (HR=1.81; CI 1.09-2.96, P=0.02) had shorter intervals to brain metastasis. Patients that underwent initial adjuvant endocrine therapy (HR=0.61; CI 0.39-0.95, P=0.03) and palbociclib therapy (HR=0.51; CI 0.28-0.96, P=0.04) had longer intervals to BM. In multivariate survival analysis, a BM onset shorter than 2 years (HR=0.24; CI 0.074-0.83, P=0.025, Figure 2C) was a protective factor.
Conclusions:Patients with early development of breast BM have better survival than patients with longer time onsets. The subtype of tumor, receptor status, systemic therapy, and high initial stage are factors related to interval from breast cancer to brain metastasis.
Sulfur removal by adding hydrogen peroxide in the Bayer liquid
Authors: Liu Shuxin , Liu Zhanwei , Yan Hengwei , Li Mengnan , Xia Chengcheng
Published: January 2023

The presence of sulfur in sodium aluminate solution has a lot of harm to the Bayer process of alumina production. H2O2 is used as oxidant to removal low valence sulfur(S2-) into high valence sulfur(S2O32-、SO32-、SO42-). this paper propose the reaction mechanism of hydrogen peroxide and different valences sulfur in sodium aluminate solution by combining the thermodynamic calculation and experiment. Through thermodynamic analysis, it is deduced that hydrogen peroxide can undergo oxidation reaction with different valence sulfur(S2-、S2O32-、SO32-) in sodium aluminate solution, and the oxidation effect of S2- is the most obvious. By studying the oxidation effect of hydrogen peroxide dosage, oxidation time, and oxidation temperature on different valence sulfur in sodium aluminate solution, it is found that the removal rate of S2- reaches 91.85% under the conditions of 9% hydrogen peroxide dosage, 260℃ oxidation temperature, and 60 min oxidation time. The experimental results are consistent with the thermodynamic calculation results. Finally, the reaction mechanism of hydrogen peroxide with different valences sulfur in sodium aluminate solution is described in detail, which provides theoretical support for the desulfurization of high-sulfur bauxite in the production of alumina by Bayer process.
Chebyshev-Jensen-type inequalities and their applications in probability theory with surround system
Authors: Wen JiaJin , Han TianYong , Yuan Jun
Published: January 2023

This paper will establish Chebyshev-Jensen-type inequalities which involving the Chebyshev products as follows:\[\langle X^{1}, X^{2}, \ldots, X^{m}\rangle_{\chi}\geq \left[ X^{1}, X^{2}, \ldots, X^{m}\right]_{\chi}\geq \chi\left( \overline{X^{1}}, \overline{X^{2}}, \ldots, \overline{X^{m}}\right)\]and\[\langle f_{1}, f_{2}, \ldots, f_{m}\rangle_{\chi}\geq \left[f_{1}, f_{2}, \ldots,f_{m}\right]_{\chi}\geq \chi\left( \overline{f_{1}}, \overline{f_{2}}, \ldots, \overline{f_{m}}\right),\]as well as display their applications in probability theory and surround system, especially, the observation angles inequalities are obtained as follows:\[1\geq \frac{1}{n}\sum_{i=1}^{n}P\left(R_{i}\right)\geq \frac{1}{n^{m}}\sum_{1\leq i_{1},\ldots,i_{m}\leq n}P(R_{i_{1},\ldots,i_{m}})\geq\left(\frac{2}{n}\right)^{m+|\alpha|}.\]The research methods of the paper are based on the mathematical induction, reorder method and the dimension reduction method.
2010 MSC: 26D15, 26E60, 51K05, 52A40
Study and structural investigation of methyl thioformate from carbon monoxide oxidation by copper nano-catalyst
Authors: Sofla Fatemeh Fallah Eri , Mahdavian Leila , Marjani Azam
Published: January 2023

Volatile sulfur compounds (VSCs) are one of the most important in food products. Chemical reactions play an important role in the production of these compounds, which has often not been scientifically evaluated. In this study, are investigated the mechanisms of methyl thio-formate production from carbon monoxide (CO) against copper oxide nano-catalyst (CuO-NC). Changing the concentration of reactants in the reaction leads to the production of different sulfur products. Three different routes for the production of methyl thioformate with different concentrations of carbon monoxide and methanethiol (CH3SH) were investigated by DFT method. The results obtained from the thermodynamic and structural point of view show the possibility of forming a reaction with equal ratio of materials (A path). By examining the charge transfer of the compounds around the copper oxide nano catalyst, it shows that in the A path, the copper atom is more positive than other reactions (0.25│e│)), and more charge transfer takes place in this reaction. One of the reasons for the stability of the structure of volatile sulfur compounds is the configuration of the structure of the compound. For methyl thioformate, there are two structural forms, cis and trans, which the analysis of the NBO method shows that the bond length and electron accumulation show the stability of the trans form.
A salt-tolerant petroleum-degrading strain Pseudomonas aeruginosa SD and its remediation potential for oily sludge
Authors: Sun Wu-Juan , Zhou Jiang , Zhang Qing-Tao , Xin Meng , Sun Rui , Ke Cong-Yu , Qin Fang-Lin , Zhang Qun-Zheng , Zhang Xun-Li
Published: January 2023

Oily sludge as highly hazardous solid waste poses a significant threat to human beings and the environment, urging the development of efficient and cost-effective treatment technologies while the bioremediation approach through microbial degradation holds great potential. In this study, a salt-tolerant and highly efficient petroleum hydrocarbon degrading strain SD was isolated from oily sludge and identified as Pseudomonas aeruginosa by 16S rRNA gene sequencing. The growth conditions and crude oil degradation performance of strain SD were characterized; the optimum growth temperature range was 30-35 oC and the salinity tolerance was up to 8%. The strain was able to rapidly grow and reproduce with petroleum hydrocarbon as the sole carbon source, and to metabolize biosurfactant rhamnolipid, prompting emulsification and dispersion of crude oil, and further oil degradation. For the crude oil with an initial dosage of 2%, the degradation rate of petroleum hydrocarbons reached 93.5% within 60 days, indicating a high degradation efficiency. Through the bioremediation experiment of oily sludge, it was found that for oily sludge with oil content of 4.25%, the degradation rate of petroleum hydrocarbons reached 92.01% within 40 days. The results demonstrated great potential for Pseudomonas aeruginosa SD towards industrial application in bioremediation of oily sludge.
Liver Injury in Children: Signal Analysis of Suspected Drugs Based on the Food and Drug Administration Adverse Event Reporting System
Authors: Liu Yan , Li Hailong , Huang Liang , Wan Chaomin , Wang Huiqing , Jiao Xuefeng , Zeng Linan , Jia Zhijun , Cheng Guo , Zhang Lei , Zhang Wei , Zhang Lingli
Published: January 2023

Purpose
Evidence of drug-induced liver injury is abundant in adults but is lacking in children. Our aim was to identify suspected drug signals associated with pediatric liver injury.
Methods
Hepatic adverse events (HAEs) among children entered into the Food and Drug Administration Adverse Event Reporting System were analyzed. A descriptive analysis was performed to summarize pediatric HAEs, and a disproportionality analysis was conducted by evaluating reporting odds ratios (RORs) and proportional reporting ratios to detect suspected drugs.
Results
Here, 14,143 pediatric cases were reported, specifically 49.6% in males, 45.1% in females, and 5.2% unknown. Most patients (68.8%) were 6–18 years old. Hospitalization ranked first among definite outcomes (7,207 cases, 37.2%). In total, 264 disproportionate drug signals were identified. The top 10 drugs by the number of reports were paracetamol (1,365; ROR, 3.6; 95% confidence interval (CI), 3.4–3.8), methotrexate (878; ROR, 2.5; 95%CI, 2.3–2.7), vincristine (649; ROR, 3.0; 95%CI, 2.8–3.3), valproic acid (511; ROR, 3.2; 95%CI, 2.9–3.6), cyclophosphamide (490; ROR, 2.4; 95%CI, 2.2–2.6), tacrolimus (427; ROR, 2.4; 95%CI, 2.2–2.7), prednisone (416; ROR, 2.1; 95%CI, 1.9–2.3), prednisolone (401; ROR, 2.3; 95%CI, 2.1–2.5), etoposide (378; ROR, 2.3; 95%CI, 2.1–2.6), and cytarabine (344; ROR, 2.8; 95%CI, 2.5–3.2). After excluding validated hepatotoxic drugs, six were newly detected, specifically acetylcysteine, thiopental, temazepam, nefopam, primaquine, and pyrimethamine.
Conclusion
The hepatotoxic risk associated with 264 signals needs to be noted in practice. The causality of hepatotoxicity and mechanism among new signals should be verified with preclinical and clinical studies.
The origin of pyroelectricity in boracite at varying temperatures
Authors: wang Qiang-qiang , sun ruijin , Guo Jie-Sen , Wu Yue-Tong , Ma Yu-Xin , Chen Fei , Liu Tian-Ming , Li Hao-Dong , Meng Fan-Shu , Meng De-Zhong , Zhao Chang-Chun
Published: January 2023

Chambersite (Mn3B7O13Cl) has excellent pyroelectric performance and promised to be a low-cost substitute for LiTaO3 and a non-toxic alternative to PbTiO3 in many application scenarios. However, the origin and mechanism of pyroelectricity in Mn3B7O13Cl at varying temperatures remain to be studied. In this work, we report the temperature-dependent crystal structure information via X-ray diffraction refinement, and based on this, we calculated the intrinsic electric dipole moments of the typical coordination polyhedral ([ClMn6]) in Mn3B7O13Cl unit cell along the c-axis at various temperature ranging from 300 to 400 K. The calculated pyroelectric coefficients based on the intrinsic electric dipole moments were in line with the experimental results, based on the above results, we can conclude that the origin of pyroelectricity in Mn3B7O13Cl is mainly the distortion of the ClMn6 polyhedron along the c-axis. Our work has understood the pyroelectric mechanism of Mn3B7O13Cl, and has played a positive role in promoting the modifications and applications for Mn3B7O13Cl and other boracite minerals.
Wheat [Triticum aestivum L.] has two copies of Starch Synthase III gene, each encodes three homeologous proteins and exhibits genotype and tissue-specific expression under heat stress
Authors: Kumar Vishnu , Nameirakpam Bipramani , Murugesh Tamilarasi , Kumari Pragya , Mishra Anurag , Panigrahi Sourav , Pankaj Yaswant Kumar , Kumar Rajeev
Published: January 2023

Starch synthase III is associated with starch accumulation in wheat. In-silico characterization indicated two homologous copies of TaSSIII gene, TaSSIIIa, and TaSSIIIb, on plus strand of chromosome 1 and minus strand of chromosome 2, respectively. TaSSIIIa shares maximum similarity with HvSSIIIa whereas, TaSSIIIb exhibited maximum similarity with OsSSIIIb. It encodes proteins with N-terminal transit peptide, SSIII-specific domain, C-terminal catalytic domain, and conserved glycosyl-transferase domain with variations among the homeologs. The catalytic domain has N-glycosylation motifs, PKC-Phospho motifs, CK2-Phospho motifs, and N-Myristyl motifs with different numbers in two homologs. ADP glucose binding motifs KVGGL and KTGGL are present in the N-terminal and C-terminal of the SS-CD and GT-1 domains, respectively. ITRLT and FEPCGLT ADP binding pockets are present at the C-terminus of catalytic domains. Maximum heterogen ligands are found in TaSSIIIa1B and minimum in the TaSSIIIb2B. TaSSIIIb expresses in leaf, stem, root, spike, & grain, and much higher amounts than TaSSIIIa. Pot-grown wheat genotypes showed heat stress induced up-regulation of the genes TaSSIIIa1D and TaSSIIIb2D in the flag leaf. 14.6-fold and 9.8-fold increase in the transcript level of TaSSIIIa1D and TaSSIIIb2D was observed in IC252874 (heat tolerant) under heat stress respectively, significantly higher than genotypes RAUWB-7, PBW 343, DBW 187, DH5 167, and HD 2967. Under the stress in field, transcript level change for TaSSIIIa1D was higher in the flag leaf and that of TaSSIIIb2D was higher in peduncle. The gene copies have tissue and genotype specific expression, get influenced by heat stress, and thus may have a role in homeostasis of starch synthesis.
MutliFusionNet: Multilayer Multimodal Fusion of Deep Neural Networks for Chest X-Ray Image Classification
Authors: Agarwal Saurabh , Arya K. V. , Meena Yogesh Kumar
Published: January 2023

Convolutional neural networks have been utilised for medical disease detection. However, most of the work is completed on the feature maps of the final convolution layer and the benefits of additional layers are not considered. The extraction of effective features from a limited medical image dataset is key for improving disease classification. In this paper, we propose a novel deep learning-based multilayer multimodal fusion model that focuses on extracting the features of different layers of the model and their fusion. Our disease detection model considered discriminatory information from each layer. Furthermore, to fuse different-sized feature maps of layers, we propose a novel feature map transform module known as the fusion of differentsize feature maps (FDSFM). The proposed model has shown a significantly higher accuracy of 97.21% and 99.60% for both three-class classification and two-class classification, respectively. The proposed model can be extended to any disease classifications from chest X-Ray images.
Collaborative public governance in African public administration contexts: Problems of realising joint actions in multi-agency arrangements
Authors: Onyango Gedion
Published: January 2023

Policy implementation challenges still need to be addressed despite the recent adoption of multi-agency joint action in improving public administration performance. However, much of what we know about joint action challenges concerns European and North American experiences with African contexts remaining vastly under-reported despite the proliferation of similar institutional arrangements in most countries. This paper conceptually illuminates this void using a trust-embedded approach to understanding inter-agency collaborations in Kenyan contexts. It argues that common joint-action challenges reside in social process deficits undergirding inter-agency relations. The paper's discussions call for systematic training and incentivisation of public managers to devise sustainable collaborative policy networks to implement policy programs effectively.
SEMANA DE DOAÇÃO DE LEITE HUMANO: RELATO DE EXPERIÊNCIA DE EVENTO DE EXTENSÃO NO FORMATO REMOTO
Authors: Fernandes do Vale Amanda , Vitória de Ataíde da Rocha Isabelle , Medeiros de Oliveira Raquel , Pinheiro de Medeiros Lays , Pedrosa Lima Simone
Published: January 2023

O objetivo deste relato de experiência é descrever a vivência de algumas integrantes do projeto de extensão intitulado Proteção, promoção e apoio a amamentação: fortalecendo a iniciativa hospital amigo da criança no Hospital Universitário Ana Bezerra (HUAB), durante o período de contribuição na semana de doação de leite humano.                                                                          O evento  se desenvolveu de maneira remota e verdadeiramente satisfatória, onde propiciou momentos singulares de união e trabalho entre os colaboradores em prol do objetivo maior que é suprir as necessidades dos lactentes assistidos e ampliar os estoques. Contudo, reafirma-se a importância de compreender os benefícios associados à doação de leite humano e também estimular a participação ativa dos envolvidos na captação de doadoras.

PALAVRAS-CHAVE: Aleitamento materno. Bancos de leite. Leite Humano. Promoção da Saúde. Saúde da Criança.
LITERATURA EM DIÁLOGO COM OS OBJETIVOS DO DESENVOLVIMENTO SUSTENTÁVEL (ODS): RELATO DE EXPERIÊNCIA
Authors: Nascimento Ilderlândio Assis de Andrade , Medeiros Pereira Verônica , Santos de Araújo Ana Maria , Dantas Ana Carla
Published: January 2023

Este relato de experiência é resultado da atividade extensionista Estudo do texto literário em diálogo com os Objetivos do Desenvolvimento Sustentável (ODS), que faz parte das atividades do Projeto de Extensão O texto literário na sala de aula. A atividade extensionista contemplou 12 ODS, que foram discutidos em diálogo com sete textos literários. Constatamos que, em sua dinâmica de grupo de leitura, a atividade estimulou o pensamento crítico-reflexivo dos participantes, promoveu/incentivou a formação leitora e, a partir da fruição do texto literário, contribuiu para a formação humana dos participantes. Ademais, a atividade extensionista mostrou que é relevante a leitura integral do texto literário e que é preciso promover leituras que façam sentido para os participantes, numa perspectiva interdisciplinar, dialógica, democrática e crítica.
PROJETO DE HUMANIZAÇÃO EM UM HOSPITAL UNIVERSITÁRIO: RELATO DE EXPERIÊNCIA DE DISCENTES DE GESTÃO HOSPITALAR
Authors: Cabral Figueredo Tayana , De Macedo Santos Ana Cristina , Magali Bezerra de Barros Rosires , Tuani Candido de Oliveira Salvador Pétala , Veríssimo e Oliveira Lannuzya
Published: January 2023

Este artigo objetiva relatar a experiência do projeto de extensão “Humanizarte UFRN:promovendo Humanização no Hospital Universitário Onofre Lopes”, desenvolvido entre osmeses de abril a dezembro de 2019, por quatro docentes e 48 discentes do curso de GestãoHospitalar da Escola de Saúde da Universidade Federal do Rio Grande do Norte. Asatividades foram realizadas em quatro etapas: 1) Seleção dos colaboradores; 2) Treinamentodos colaboradores; 3) Realização das intervenções; e 4) Avaliação das intervenções. Conclui-se que as práticas de intervenção com ênfase na humanização, que utilizam estratégias lúdicase artísticas, além de trazer benefícios para usuários e profissionais dos serviços de saúdecontemplados, contribuem com a formação técnica e ética dos discentes envolvidos.
PROTOCOLO PARA TERAPIA NUTRICIONAL NA DISTROFIA MUSCULAR DE DUCHENNE
Authors: Carvalheira Dourado Laura , Teixeira Dourado Júnior Mário Emílio , Câmara Grilo Evellyn , De Lima Vale Sancha Helena
Published: January 2023

A Distrofia Muscular de Duchenne (DMD) é uma doença progressiva recessiva ligada ao cromossomo X, caracterizada por fraqueza muscular e possíveis complicações no sistema cardiorrespiratório e digestivo. Este artigo é uma revisão de literatura, cujo objetivo é elaborar um protocolo para terapia nutricional na DMD, para subsidiar a prática clínica da equipe de nutricionistas e estudantes do curso de Nutrição que atuam no projeto de extensão Assistência nutricional nas distrofias musculares infantis, desenvolvido no ambulatório de doenças neuromusculares do Hospital Universitário Onofre Lopes/ UFRN. A seleção de artigos foi feita nas bases de dados Pubmed e Embase, utilizando descritores padronizados. O protocolo elaborado, baseado em evidências científicas, poderá auxiliar na tomada de decisão sobre o tratamento dietoterápico de indivíduos com DMD.
PLANTÃO PSICOLÓGICO REMOTO: POSSIBILIDADES E LIMITAÇÕES
Authors: Fernandes de Medeiros Luciana , MOURA MEDINA GURGEL Melanie , Nunes Gadelha Maria José , KARIELLY FERNANDES Évilla , VANESSA DE OLIVEIRA PONTES Erika , MAGAZILI DE OLIVEIRA Jeane
Published: January 2023

O presente relato de experiência tem como objetivo apresentar o projeto de extensão “Cuidar da existência - plantão psicológico no Serviço-Escola de Psicologia da Faculdade de Ciências da Saúde do Trairi/Facisa/UFRN” analisando, principalmente, o trabalho realizado durante o período de pandemia de COVID-19. O projeto vem sendo desenvolvido desde 2018 com a participação dos discentes do curso de psicologia da Facisa/UFRN, duas psicólogas técnicas do serviço e duas docentes. Com a pandemia de COVID-19, entre 2020 e 2022, o projeto de extensão passou a ser realizado no formato remoto para poder atender à população local, bem como estudantes e servidores da Facisa/UFRN. No relato, é apresentado os desafios e as possibilidades do plantão psicológico no formato remoto, bem como as demandas atendidas durante esse período.
NEUROEDUCAÇÃO E TRANSTORNOS DE APRENDIZAGEM:
Authors: Lopes Costa Freire Katia Regina , Alves Marinho Santos Analice , Costa Débora
Published: January 2023

Neste Relato de Experiência destacamos as ações, metodologias e resultados obtidos com o Projeto de Extensão “Neuroeducação, Transtornos e Dificuldades de Aprendizagem: estratégias de ensino e avaliação” promovido pelo Departamento de Educação do Centro de Ensino Superior do Seridó (CERES) da Universidade Federal do Rio Grande do Norte (UFRN). O Projeto de Extensão ocorreu contou com profissionais de diversas áreas que relataram suas experiências tendo como aporte teórico os conhecimentos da Neurociências, Psicologia Social e Educação, cumprindo um dos objetivos principais dos projetos de extensão que é a articulação entre teoria e prática, sendo também, um processo educativo. Como resultados alcançados, destacamos a partilha de experiências e reflexão acerca da inclusão de alunos com Transtornos e Dificuldades de Aprendizagem.
Modified Asparaginase for Treatment of Cancer Historical Appraisal and
Future Perspectives
Authors: Icart Luis Peña , de Araújo Talita Stelling , Almeida Marcius da Silva , Trambaioli da Rocha e Lima Luís Maurício
Published: January 2023

Asparaginase (ASNase) is widely used as an important component of first-line treatment
for acute lymphoblastic leukemia (ALL). Although it is associated with a high rate of complete remission
(~93%), challenges remain due to several side effects ranging from immune reactions to
severe toxicity, largely associated with its higher immunogenicity and glutamine coactivity. Innovative
products have therefore been devised to minimise these adverse reactions while increasing the
enzymes’ pharmacokinetic properties, stability, and efficacy. This review focuses on commercially
available formulations and others that remain in development, discussing the most recent strategies
for preparing alternative formulations of the enzyme to be less immunogenic and have low glutaminase
coactivity by using site-specific mutagenesis, PEGylation, and encapsulation techniques.
Sistem Kontrol Kadar Gas Karbon Monoksida (CO) Pada Aplikasi Modified Atmosphere Packaging (MAP) Berbasis Fuzzy Logic
Authors: Supriyatna Reza , Nuryanti Nuryanti , Salam Abyanuddin
Published: January 2023

Karbon Monoksida (CO) dalam teknologi makanan digunakan sebagai salah satu gas komponen penyusun dalam proses Modified Atmosphere Packaging (MAP). Karbon Monokida pada proses MAP digunakan untuk mempertahankan warna daging, dengan konsentrasi 0,3 hingga 0,5%. Pengendalian kadar gas karbon monoksida yang masuk ke kotak MAP menggunakan servo valve. Presentase buka tutup servo valve diatur menggunakan fuzzy logic yang diprogram pada mikrokontroler Arduino Mega. Hasil pengujian didapatkan bahwa sistem mampu mencapai setpoin yang diinginkan dengan keadaan awal yang berbeda â€“ beda yang memiliki rata â€“ rata error kurang dari 5%. Respon sistem kendali fuzzy logic masih memiliki overshoot pada awal respon yang diakibatkan oleh keterlambatan pembacaan sensor MQ7. Hasil keluaran fuzzy logic didapatkan bahwa rata â€“ rata akurasi hasil fuzzy logic pada program Arduino (perhitungan) dengan hasil fuzzy pada Matlab sebesar 98,84% untuk servo valve inputÂ  dan 96,23% untuk servo valve output.
Disembodied behavior and communication effectiveness in learning activity during the Covid-19 pandemic era
Authors: Suwatno Suwatno , Adman A. , Hadijah Hady Siti , Islamy Fahmi Jahidah , Muhidin Aeng
Published: January 2023

Currently, Corona is a hot topic of discussion. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2), better known as the coronavirus, is a new type of coronavirus that causes infectious diseases in humans. The online learning system (on the network) is the answer for universities to continue to carry out academic activities. Online learning is a learning system without face-to-face directly between lecturers and students but is done virtually. Lecturers must ensure that teaching and learning activities continue while students are at home. The solution is that lecturers must be able to design learning activities as innovations by utilizing online media to continue running effectively. Communication between students and lecturers through video conferencing raises several problems: the low creativity of students, the difficulty of achieving communication effectiveness, and generating demotivation and disembodied behavior. The purpose of this study was to determine the level of (1) effectiveness of virtual lecturer communication based on student perspectives, (2) student demotivation, (3) student disembodied behavior, and (4) student creativity. This research uses a descriptive method. The sampling method used is incidental sampling, where the subjects studied are lecturers and students willing to participate in filling out research questionnaires. The number of lecturers in this study was 91 people from 25 universities in the city of Bandung, with a total of 100 courses, so a sample size of 200 sampling units was obtained, where the sampling unit was lecturer-subjects. The results showed that the student creativity variable was in the high category, the demotivating variable was in the low category, the disembodied behavior variable was in the moderate category, and the lecturer's communication effectiveness variable was in the very high category