bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Edutourism "Kampung Inggris" on the Improvement of Community Welfare in South Tetebatu Village, Lombok, Indonesia
Authors: Suriani Suriani , Fatriani Emilia
Published: December 2022

Purpose: This Research aims to determine the contribution of English Village educational tourism to the level of welfare of the people of South Tetebatu.
Methods: The method in this study uses qualitative methods with a case study approach. Primary research data comes from the Tetebatu Selatan Village Government and Staff, as well as the Tetebatu Selatan Village Community using interview, observation and documentation methods. Data analysis techniques using data reduction, data display and drawing conclusions. While the validity of the data using the extension of the presence of researchers and triangulation of sources.
Result: The results of this study indicate that the English Village of South Tetebatu has had a positive impact on the economy and the level of welfare of the people of South Tetebatu which is marked with 1). Hotels and inns for residents close to Kampung Inggris are starting to be filled by course participants for places to stay, 2). The stretching of UMKM has also started to show results, with the presence of several small traders in the English Village area, and the spread of the laundry business, 3). Opening new job vacancies, namely providing opportunities for local people to become tutors, and other businesses such as laundry and catering certainly require employees for their operations, 4). increase the income of the local community, which has implications for the level of community welfare. In addition to the positive impact, the existence of Kampung Inggris also has a negative impact, namely the occurrence of social conflict due to the uneven distribution of beneficiaries from the Kampung Inggris Tetebatu Selatan edutour, as well as conflicts of interest between tourism development, schools and the community, by taking over part of the school land for the construction of Rest Areas and Pertashops .
Contribution: this reseach is practically to be useful as input from stakeholders in South Tetebatu Village in improving the welfare of local communities with the development of tourist villages. The development of community-based tourist villages that prioritize community participant in the development of tourism Village is very necessary to improve the welfare of local communities and can reduce conflicts.
Development of outcomes-based instructional materials in professional teacher education courses for a flexible set-up
Authors: Alciso Romarate Marilou , Boo Aquino Anania , Julongbayan Punongbayan Estelito , Ramos Quizon Gliceria , Aclan Balilla Leolanda , Porley Ramos Noraida
Published: December 2022

This study developed outcomes-based instructional materials in three professional teacher education courses based on an assessment of the different kinds of instructional materials used, their availability and frequency, challenges faced by faculty members and students in using the instructional materials and the perceived need to develop instructional materials. A descriptive research design was used to collect data while a developmental research design was applied for the development of outcomes-based instructional materials. The researchers constructed a questionnaire using a 4-point Likert scale. The online questionnaire was completed by 38 faculty members and 655 pre-service teachers from Batangas State University, Philippines. The data collected were analyzed using descriptive statistics and the Mann-Whitney U Test. The results showed that there are various instructional materials used in the three professional courses and they are used based on appropriateness and suitability. Both faculty members and pre-service teachers faced similar challenges in the utilization of these instructional materials as revealed by the Mann-Whitney U Test. These findings served as the basis for the development of three outcomes-based instructional materials that followed the sequence of activity, analysis, abstraction, and application. The instructional materials were subjected to evaluation and found satisfactory in content and format. Recommendations given were incorporated in the final copy.
Educação musical e sociologia da infância no Brasil: diálogos em construção
Authors: Cunha Sandra , Brito Dhemy , Oliveira Sarah
Published: December 2022

A relação da educação musical com a sociologia da infância é o objeto de estudo sobre o qual este artigo se debruça , com o objetivo de compreender como os diálogos entre as duas áreas têm sido estabelecidos no âmbito das produções acadêmicas brasileiras. Para tanto, adotou a pesquisa bibliográfica do tipo estado do conhecimento como metodologia. Nove teses e nove dissertações produzidas entre 2008 e 2021 em programas de pós-graduação de Educação e de Educação Musical compuseram o corpus desta pesquisa. A análise do material arrolado oportunizou conhecer quais são os programas de pós-graduação nos quais as pesquisas foram realizadas, as regiões do país nas quais eles estão localizados, o ano de produção dos trabalhos, os contextos educativos, as metodologias de pesquisa adotadas, as temáticas de estudo e os(as) autores(as) da sociologia da infância que fundamentaram essas produções. Como resultados, o levantamento realizado neste estudo revelou que a relação da educação musical com a sociologia da infância está em processo de construção, com crescimento expressivo na segunda metade do período analisado. Como conclusão, assinala as contribuições da sociologia da infância à educação musical, aponta a existência de espaços para a ampliação das pesquisas e ressalta a relevância de estudos que tragam à tona as vozes infantis que ecoam em espaços plurais de ensino e aprendizagem da música.
DESIGN OF A MANIPULATOR OF A CONVEYOR FOR BULK MATERIALS – CALCULATION OF THE CENTER OF GRAVITY OF THE CONVEYOR
Authors: BLATNICKÝ Miroslav , DIŽO Ján , MOLNÁR Denis , DROŹDZIEL Paweł
Published: December 2022

The predominant goal of the research presented in this paper is the design of a manipulator for a conveyor of bulk materials based on the given requirements. This issue is an emerging topical one mainly for the reasons of increasing efficiency and speed, as well as the safety of maintenance of machines and equipment. Especially, another essential aspect is the reduction of the physical strain on operators during service operations on the conveyor of bulk materials. The introductory part of this paper attends to the materials used for the production of steel structures, their technological processing, as well as different types of joining of their components. The practical part was set out to ascertain the mass and position of the center of gravity of the load itself – the conveyor. From the perspective of acting, it loads the entire proposed structure, although in different operating modes.
O CONCEITO DE RESPONSABILIDADE EM LÉVINAS: OS LIMITES ENTRE A DISTANÁSIA E OS CUIDADOS PALIATIVOS
Authors: Oliveira Lino Batista de , Siqueira José Eduardo de , Gutschow Julia Hespanhol , Gutschow Giovanna Hespanhol
Published: December 2022

Resumo: Na contemporaneidade, observa-se grande prevalência de enfermidades crônicas sem possibilidade de cura, que se acompanham de significativa redução da qualidade de vida do paciente. Os cuidados paliativos têm como finalidade proporcionar ao paciente conforto físico e emocional na terminalidade da vida. Em momentos em que os CP são negligenciados de alguma forma e deixam de ser exercidos de maneira plena, pode ocorrer a prática da distanásia – procedimentos que apenas prolongam o processo de morrer. A reflexão de Emmanuel Lévinas é caracterizada pelo desenvolvimento do projeto de uma Primeira Filosia, a qual aborda nova compreensão da subjetividade humana pela valoriza­ção da ética em detrimento da ontologia fundamental. Esse projeto tem como objetivo apresentar o conceito de responsabilidade em Emmanuel Lévinas e sua aplicação no estudo dos limites dos cuidados paliativos para que se evite procedimentos médicos distanásicos.
Palavras-chave: Bioethics. Social Responsibility. Palliative Care. End-Life Care. Physician-patient relations.
International Scientific and Practical Conference “Personal Book Collections and Archives in Libraries (on the 80th Anniversary of B. S. Elepov”)
Authors: Editorial Article
Published: December 2022

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Pemikiran Mahmud Yunus dalam Pembaruan Pendidikan Islam di Indonesia
Authors: Hamzah Syeh Hawib
Published: December 2022

Mahmud Yunus is one of the pinoers of the Islamic education in Indonesia. Some of his huge important thoughts are: accommodating the Islamics lesson as an obligatory lesson in the schools, establishing the state SGHA, establishing the PGA, provoking the equality of the certificate of madrasah graduation, and pioneering the decree of Islamic Higher Education. The thoughts of Mahmud Yunus was influenced by his hometown local wisdom, his visits to middle-east nations, and the time when he was in the religious department.
Penanaman Nilai-Nilai Multikultural: Studi Kasus Pada Pesantren Nabil Husein Samarinda Kalimantan Timur
Authors: Khojir Khojir
Published: December 2022

Pesantren Nabil Husein is the biggest pesantren in Samarinda. It is not only because of the wide area of it, but it is also because of the total number of its students as well as its programs. Its students and teachers are from different places and educational background. This study tried to describe the media and the model in the teaching of multiculturisme values at Pesantren Nabil Husein Samarinda. This is a sociological and pehenomenological qualititave research. The data and data sources were from the ustadz, the headmasters, the owner, the managerial staffs, and the students. The data sampling technique used purposive sampling. The data collection used interview, observation, and documentation. The data validation used data triangulation. The data were analyzed by using three stages of data analysis, they are: data reduction, data display, and coclusion drawing. The result of the study shows that: 1) the media used to reinforce the multiculturisme values are the students’ orientation activity, dormitory, ta’lim al-Diniyah, art and culture performances, and halaqah; 2) the model used to reinforce the multiculturalisme values are the action-reflection and action model, ignasian and practice model, empirical model, and rasional model. Based on the findings, it is suggested the dormitory managerial staffs become more intensive in reinforcing the multiculturalisme values especiallyat al-Azhar room, all teachers and managerial staffs should have a same vision in reinforcing the multiculturalisme values, and the non-academical activities should be improved in reinforcing the multiculturalisme values.
Karakteristik Proses Pembelajaran Kurikulum 2013
Authors: Shafa Shafa
Published: December 2022

In PP No 32 tahun 2013, it was found that four of eight national educational standards has significantly changed. The four standards are: 1) the graduation compentency standard has been revised and renewed in Permendikbud No 54 Tahun 2013; 2) the content standard is renewed in Permendikbud No 64 Tahun 2013; 3) the process standard is renewed in Permendikbud No 65 Tahun 2013; and 4) evaluation standard is renewed in Permendikbud No 66 Tahun 2013. One of the four standards that is very interesting to discsuss is the process standard which is focusing on how the ideal model of a teacher plans, implements, and evaluates teaching and learning process. This process standard is one of the curriculum anatomies which covers a model, approach, strategy, method, and technique of teaching implemented by a teacher in administering the content of learning to achieve the goals of teaching has been made. This paper tries to explore the characteristics of ideal teaching targeted by the national curriculum 2013 which is focusing on the principles of learning, characteristics, planning, and the implementation of curriculum 2013.
EFL Students' Views of the Multicultural Education in an Indonesian Islamic Higher Education
Authors: Shafa Shafa
Published: December 2022

Education cannot be separated from culture. It is possible to provide learning and be tolerant of other cultures. Multicultural education offers diverse cultures, ethnicity, and religion. The study aims to explore students' views of multicultural education in learning at an Indonesian Islamic higher education. It employs a descriptive study by applying a quantitative approach. By considering the ethnic and study program, respondents in this study were determined through the purposive sampling technique by involving 25 students from the Faculty of Tarbiyah and Teacher Training UINSI Samarinda, each representing five different study programs in the faculty. They enrolled as Ma’had Al-Jami’ah students obligated to study English in their initial semester. They were chosen from various study programs because they came from different ethnic backgrounds. This study collects data with a questionnaire instrument distributed online through a Google Forms. Descriptive statistics were used to tabulate and present the quantitative data collected from the questionnaire. The findings in this study provide an overview of the different perspectives of students at Islamic higher education on multicultural education in their learning. This study groups students' views of multicultural education in learning at Islamic higher education into three categories, (1) Highly Supportive on Multicultural Education, (2) Moderately Supportive on Multicultural Education, and (3) Lowly Supportive on Multicultural Education. Most of them have understood the values of multicultural education and are very supportive of its implementation in every lecture and campus policy but there are still students who do not understand the values of this multicultural education. Continuous studies are necessary to support the application of this multicultural education from time to time according to the needs of each institution.
MUSLIM INTENTION TO PARTICIPATE IN RETAIL CWLS: THE TEST OF MEDIATION AND MODERATION EFFECTS
Authors: Berakon Izra , Mutmainah Lu’liyatul , Qoyum Abdul , Aji Hendy Mustiko
Published: December 2022

Cash Waqf-Linked Sukuk (CWLS), which integrates cash waqf instruments and sovereign Sukuk, is an innovative Islamic investment product with social and spiritual dimensions. This study investigates public intention to participate in Retail CWLS (SWR) using the Technology Acceptance Model (TAM) framework with the addition of other relevant constructs. An online survey was conducted using the purposive sampling technique and involved 130 respondents. The data were analysed using Partial Least Squares Structural Equation Modeling (PLS-SEM) supported by WarpPLS. The results indicate that Perceived Ease of Use (PEOU), Perceived Usefulness (PU), Perceived Transparency (PT), and Trust in the Indonesian Waqf Board and Waqf Institutions have a significant positive effect on individual Intention to participate in Retail CWLS. Furthermore, this study reveals that Trust could partially mediate the relationship between PU and individual Intention. However, Religiosity fails to moderate the relationship between PU and individual Intention to purchase SWR. The study also demonstrated other complementary statistical outputs such as split-sample, non-linear relationships among latent variables, effect size, and the Q-squared coefficient to ensure that the processed data were robust. Also, this finding indirectly implies that CWLS is not only targeted at the Muslim community but also for general investors from other religions and beliefs.
The Use of Angelica Sinensis and β-tricalcium Phosphate in the Management of Surgically Induced Critical-sized Class II Furcation Defects in Dogs
Authors: Eldeeb Dina W. , Hommos Ahmed M. , Taalab Maha R. , Rehim Samia S. Abd El
Published: December 2022

Objective: Evaluating the effectiveness of Angelica sinensis, a widely used traditional Chinese medicine, in conjunction with Beta-tricalcium phosphate (β-TCP) bone graft in the management of induced critical sized class II furcation defects in adult healthy mongrel dogs.
Materials and Methods: A randomized study design was conducted on the third and fourth premolars of six healthy mongrel dogs. A total of twenty-four class II furcation critical-sized defects were surgically created. After reflecting a fully-reflected mucoperiosteal flap, twelve defects were filled with Angelica sinensis powder mixed with Beta-tricalcium phosphate (β-TCP), then collagen membranes were applied over the defects (experimental group). The other twelve defects were filled with β-TCP followed by collagen membrane application (control group). The dogs were sacrificed at the end of fourth and eighth weeks. Jaw segments containing the operated teeth were dissected and processed for histological examination and morphometric analysis of the regenerative features.
Results: The histological results revealed that bone formation and regeneration of cementum and PDL progressed more in experimental groups than in control groups. Moreover, the regenerative features were more advanced in the second observation period. The histomorphometry revealed that the surface area of newly formed bone and the thickness of its trabeculae were higher in the defects treated with Angelica sinensis and β-TCP than in only β-TCP-filled defects at both observational periods.
Conclusions: Angelica sinensis has accelerated the regenerative potential of the interradicular bone and has enhanced the effect of β-TCP for interradicular bone regeneration in dogs.
Application of constrained implants hip arthroplasty in patients with hip neuromuscular disease
Authors: Zhang Yanfang , Liu Zeming , Liu Sikai , Li Mengnan , Liu Bo , Han Yongtai , Wu Tao
Published: December 2022

Background: It is well known that neuromuscular diseases increase the risk of complications after hip replacement.The purpose of this study was to investigate the clinical manifestation and survival rate of total hip arthroplasty (THA) with constrained implants in inpatients with neuromuscular diseases.
Method: A retrospective study evaluated the results of 17 THA in 17 patients with hip neuromuscular disease from April 2018 to June 2020. The average age at the time of operation was 66.71 years (33-86 years). The average follow-up time was 34.44 months (25-50 months). All surgery were operated through posterolateral approach. These were cementless implants.
Result: The incisions of all cases healed in one stage, without infection, injury of important nerves, blood vessels and other tissues, loosening of joint prosthesis and deep venous thrombosis of lower limbs. One of the patients developed a new cerebral infarction at postoperative, which affected the contralateral limb movement and seriously affect the postoperative efficacy observation. The others were followed up for 25 months to 50 months, with an average of (34.44±8.05) months. All patients underwent THA with constrained implants. The hip joint function was evaluated according to Harris Hip score standard, excellent in 2 cases, good in 12 cases and poor in 2 cases.
Conclusion: THA combined with constrained implants has been shown to be effective in reducing the risk of dislocation and enhancing stability for patients with neuromuscular disease.
Green Synthesis of Copper Oxide Nanoparticles Using Leaf Extract of Justicia Schimperiana and their Antibacterial Activity
Authors: Melkamu Walelign Wubet , Feleke Eskedar Getachew
Published: December 2022

A fast, efficient, simple and environmentally-friendly, green synthesis method was employed for the synthesis of copper oxide nanoparticles (CuONPs) using easily available, low-cost and non-toxic Justicia Schimperiana plant leaf extract (JSPLE) from Ethiopia. Ultraviolet-Visible (UV-Vis) spectrophotometer, X-ray Diffraction (XRD) technique and Fourier-Transform Infrared (FTIR) Spectroscopy were used to characterize the synthesized CuONPs. The UV-Vis confirmed the formation of CuONPs and the maximum absorbance for the synthesized CuONPs in solution at 212 nm. The different parameters like penta hydrated copper sulphate concentration, volume of leaf extract, temperature, pH and time were optimized spectrophotometrically. The FTIR analysis confirmed the existence of various functional groups responsible for reducing and stabilizing during the biosynthesis process. The XRD result confirmed that the synthesized CuONPs were crystalline in nature with the monoclinic structure and the average crystallite sizes of the particles were 21.8 nm. The synthesized CuONPs showed antimicrobial (gram-negative bacteria (Salmonella typhimurium,Escherichia coli and Klebsiella pneumoniae) and grampositive bacteria (Staphylococcus aureus)) activity. It has been noted that the green synthesized CuONPs showed efficient antibacterial activity against gram-negative (salmonella typhimurium) bacteria with maximum ZOI of 18.6 mm with respect to the highest concentration (150 μg/mL). The developed method for the CuONPs synthesis using JSPLE is an eco-friendly and convenient method. In the near future, the synthesized CuONPs could be used in the fields of biomedicine, biosensor, water treatment and nanotechnology.
Evaluation of the implementation of hospital hygiene components in 30 health-care facilities in the Autonomous District of Abidjan (Cote d'Ivoire) with the WHO Infection Prevention and Control Assessment Framework (IPCAF)
Authors: Cissé Doumbia Mariamou , Essis Esme Marie Laure , Koné Atioumounan Blaise , Ngbesso Jean Paul Ngbesso , Mbengue Valérie Gbonon , Cissé Raïssa Adja Mayaka , Gagne Doh Eugénie , Dagnan N’cho Simplice , Kouadio Luc Philippe , Samba Mamadou
Published: December 2022

Introduction

As part of the implementation of its mission "to integrate hygiene activities into health-care", the general directorate of health conducted in 2018 with its technical structures, an evaluation of the implementation of Infection Prevention and Control (IPC) using the WHO IPCAF tool in 30 health-care facilities in the autonomous district of Abidjan.

Material and methods

This was a cross-sectional survey with a conceptualized component considering the issue of injection safety and sanitary waste management, which was conducted in the named health-care facilities from March 20 to 28, 2018. The scores of the essential components of the IPC made it possible to assess the IPC level of each health-care facility evaluated and the overall IPCAF score of all facilities.

Results

The overall median IPCAF score of the health-care facilities was 242.5/800 and corresponded to an inadequate level overall. No facility reached the "advanced" level of performance, 5 facilities (17%) reached the "intermediate" level, 10 (33%) fell into the "basic" level, and 15 (50%) were at the "inadequate" level. Baseline institutions had much higher scores than first contact institutions.

Conclusion

IPC component activities were inadequate and fragmented in the under-resourced health facilities at the time of the assessment. It would be appropriate to provide adequate resources and develop expertise in IPC through strong political will and leadership. This will contribute to the achievement of universal health insurance objectives with safe health services for patients.
UTX inhibition suppresses proliferation and promotes apoptosis in patient-derived glioblastoma stem cells by modulating periostin expression
Authors: Luan Yan , Liu Yingfei , Xue Jingwen , Wang Ke , Ma Kaige , Lu Haixia , Chen Xinlin , Liu Yong , Zhang Zhichao
Published: December 2022

Glioblastoma stem cells (GSCs) link tightly to glioblastoma (GBM) development, progression, therapeutic resistance and recurrence, suggesting GSCs as a novel target for drug discovery. UTX, a histone H3K27 demethylase, participates in regulating multiple cancer types. However, less is known about the function of UTX in GBM, let alone in GSCs. Our study aims to investigate the role and regulatory mechanism of UTX on GSCs. TCGA data showed that higher UTX expression was found in GBM and inversely correlated with survival. UTX inhibition hindered GBM cell growth and caused cell apoptosis. Subsequently, we cultured the primary GSCs, which were isolated from three patients. UTX inhibition suppressed cell proliferation and promoted apoptosis in GSCs. RNA-seq was performed to analyze the gene expression changes after silencing UTX in GSCs. The results indicated that UTX-mediated genes were strongly correlated with GBM progression and regulatory tumor microenvironment (TME). Transwell co-cultured experiment showed that silencing UTX in the transwell chamber GSCs could also inhibit the well plate cell proliferation. Protein-protein interaction analysis revealed that periostin (POSTN) played a role in the UTX-mediated transcriptional regulatory network. Replenishment of POSTN abolished the effect of UTX inhibition on GSCs proliferation and apoptosis, ablated the differential expression of intra- and extracellular levels of COL1A1 and VCAM1. Combining the above results together, our study demonstrated that UTX inhibition hindered POSTN expression by enhancing the H3K27me2/3 level, eventually resulting in inhibiting proliferation and promoting apoptosis of patient-derived GSCs. Our findings may provide a novel and effective strategy for the treatment of GBM.
Establishing a prognostic model of chromatin modulators and identifying potential drug candidates in renal clear cell patients Introduction
Authors: Liu Puyu , Luo Jihang , Tan Na , Li Chengfang , Xu Jieyu , Yang Xiaorong
Published: December 2022

Background: Renal carcinoma is a common malignant tumor of the urinary system. Advanced renal carcinoma has a low 5-year survival rate and a poor prognosis. More and more studies have confirmed that chromatin regulators(CRs) can regulate the occurrence and development of cancer. This article aims to investigate the functional and prognostic value of CRs in renal carcinoma patients.
Methods: mRNA expression and clinical information were obtained from the TCGA(The Cancer Genome Atlas)database. Univariate Cox regression analysis and LASSO regression analysis were used to select prognostic chromatin-regulated genes and use them to construct a risk model for predicting the prognosis of renal cancer. Differences in prognosis between high-risk and low-risk groups were compared using Kaplan-Meier analysis. In addition, we analyzed the relationship between chromatin regulators and tumor immune infiltration, and explored differences in drug sensitivity between different risk groups.
Results: We constructed a model consisting of 11 CRs to predict the prognosis of renal cancer patients, and not only successfully validated its feasibility, but we also found that the 11 CR-based model was an independent prognostic factor. Functional analysis showed that CRs were mainly enriched in cancer development-related signaling pathways. We also found through the TIMER database that CR-based models were also associated with immune cell infiltration and immune checkpoints.At the same time, the GDSC(The Genomics of Drug Sensitivity in Cancer database)database was used to analyze the commonly used drugs of KIRC(Renal clear cell carcinoma) patients. It was found that patients in the low-risk group were sensitive to drugs such as axitinib, pazopanib, sorafenib, and gemcitabine, while those in the high-risk group may be sensitive to sunitinib.
Conclusion: The chromatin regulator-related prognostic model we constructed can be used to assess the prognostic risk of patients with clear cell renal cell carcinoma. The results of this study can bring new ideas for targeted therapy of clear cell renal carcinoma, helping doctors to take corresponding measures in advance for patients with different risks.
LncTUG1 contributes to the progression of hepatocellular carcinoma via the miR-144-3p/RRAGD axis and mTOR/S6K pathway
Authors: Chen Weixi , Bai Zekun , Bai Wen , Wang Wei , Guo Jiapei , Guo Mengnan , Sai Yingying , Shi Jun , Wu Jinghua
Published: December 2022

Background: Hepatocellular carcinoma (HCC) is a symptomatic disease involed multi-stage program. Here, we elucidated the molecular mechanism of LncTUG1 in the regulation of HCC evolvement. And that may in all likelyhood supply a innovative latent target for HCC’s diagnoses and prognosis.
Methods: LncRNA TUG1, miR-144-3p, RRAGD and mTOR signaling pathway were screened as target genes in the database, and their expression levels at the cytological level were verified utilized qRT-PCR, Western Blot and immunohistochemistry. Then, we adopted CCK-8, Transwell and flow cytometry assays to estimate cell proliferation, invasion and apoptosis. By use of luciferase reporter assay, the relationships of LncRNA TUG1, miR-144-3p and RRAGD was confirmed. In addition, the LncRNA TUG1-miR-144-3p-RRAGD-mTOR signaling pathway in HCC cells was verified adopted rescue experiment and confirmed by xenotransplantation animal experiment
Results: LncTUG1 in HCC tissues from three databases were identified and further verified through qRT-PCR in HCC cells (Huh7, Hep3B). Knockdown the LncTUG1 could increase apoptosis and inhibite invasion and proliferation in HCC cells. Using inhibitors and activators of the mTOR/S6K pathway, LncTUG1 was confirmed to regulate HCC progression by the mTOR/S6K pathway. Luciferase reporter assay demonstrated that TUG1 negatively regulates miR-144-3p. Furthermore, miR-144-3p negativly regulates RRAGD by way of interacting with the 3’UTR of the RRAGD mRNA in HCC utilized luciferase reporter assay. In vivo, we also discovered that neoplasm weight and tumor volume reduced significantly in subcutaneous xenograft nude mouse models derived from sh-LncTUG1-expressing Huh7 cells. And the expressions of p-mTOR, p-S6K and RRAGD were decreased obviously while the miR144-3p increased in subcutaneous xenograft nude mouse models.
Conclusion: In a word, the research suggests that LncTUG1 targets miR-144-3p while miR-144-3p binds to RRAGD mRNA, which induces mTOR/S6K pathway activation and promotes the progression of HCC.
Lysinibacillus capsici 38328 Isolated from Agricultural Soils as a Promising Probiotic Candidate for Intestinal Health
Authors: Chen Huinan , Sun Xiaoyi , He Huilin , Ren Hongkun , Duan Haoyuan , Zhang Chuankun , Chang Qingru , Zhang Runxiang , Ge Junwei
Published: December 2022

There is an increasing interest in the use of spore-forming Bacillus spp. as probiotic ingredients on the market. However, probiotics Bacillus species are insufficient, and more safe Bacillus species were required. In the study, traditional fermented foods and soil samples were collected from all over the country in China, and 506 Bacillus were selected from 109 samples. Using the optimized procedure, we screened 9 strains, which successfully passed the acid, alkali, bile salt and trypsin resistance test. Drug sensitivity test results showed that three Bacillus out of the 9 isolates exhibited antibiotic sensitivity to more than 29 antibiotics. The 3 strains sensitive to antibiotics were identified by 16S ribosomal RNA, recA and gyrB gene analysis, two isolates (38327 and 38328) belong to the specie Lysinibacillus capsici and one isolate (37326) belong to Bacillus halotolerans. Moreover, the 3 strains were confirmed safe through animal experiments. Finally, L. capsici 38327 and 38328 showed the protection in Salmonella typhimurium infection mouse model, which manifested in slowing down weight loss, reducing bacterial load, improving antioxidant capacity. Altogether, our data demonstrate selected L. capsici strains can be used novel probiotics for intestinal health.
Effects of facial ugliness on the bad and ugly judgments of unethical behavior: an fMRI study
Authors: chengqiuping Qiuping , Zhou Ying , Zhang Yuman , Zhou Mi , Mo Lei
Published: December 2022

Objective: Unethical behavior has a powerful effect on an individual's overall judgment and is easily influenced by their looks. However, it remains unclear whether the unethical behavior of ugly-looking individuals is more likely to be judged as immoral and what the mechanisms behind it are. The present study investigates whether facial ugliness influences the bad and ugly judgments of unethical behavior from the perspective of neural mechanisms.
Method: The experimental material consisted of scenarios describing different levels of unethical behavior committed by ugly-looking or non-ugly-looking people. Subjects were asked to rate the bad and ugly levels of behaviors on a 4-point scale while being scanned for brain activity. We conducted a parametric general linear model (GLM) to estimate neural responses to facial ugliness in morally bad and ugly judgments, which varied with the level of immorality.
Results: The results showed that ugly-looking faces activated the anterior cingulate cortex and bilateral inferior occipital gyrus in both judgments, indicating a task-general pattern. Ugly-looking faces in morally ugly judgment showed stronger activity than in morally bad judgment in the ventromedial prefrontal cortex, left insula, left middle temporal gyrus, and cortical midline structures that characterize the emotional significance of events, suggesting a task-specific pattern.
Conclusions: The results of the current study demonstrate that facial ugliness is task-specific as well as task-general in evaluating unethical behaviors. The findings provide more experimental and neurological evidence for the understanding of the essence between morality and aesthetics.
Improving access to assessments of early motor development in local languages: Polish adaptation of the Early Motor Questionnaire
Authors: Laudańska Zuzanna , Szmytke Magdalena , Radkowska Alicja , Malinowska-Korczak Anna , Babis Karolina , Pérez David López , Tomalski Przemysław
Published: December 2022

A child’s motor development progresses very dynamically. It is crucial to develop freely available parent-report measures of motor development that can be easily used globally to measure motor skills and identify children in need of interventions. Here, we present the adaptation and validation of the Early Motor Questionnaire, which consists of gross motor (GM), fine motor (FM), and perception-action integration (PA) subscales, to the Polish language (EMQ-PL). In Study 1 (online, N=640), we observed its excellent psychometric properties and significant differences in GM and Total age-independent scores between children that were and were not referred for physiotherapy. In Study 2 (in-person assessment, longitudinal, N=100), we show high correlations of GM and total scores with Alberta Infant Motor Scale. Overall, we show that the EMQ can be easily adapted to local languages and has a potential for use as a screening tool.
Construction of Feature Analysis Model for Demeanor Evidence Investigation Based on Data Mining Algorithm
Authors: Zhang Mengxing , Qi Lin , Guo Yulong
Published: December 2022

Demeanor evidence refers to the authoritative opinions of experts using analytical instruments to collect and interpret the formation of external physiological symptoms of the entire human body.The use of man-made reasoning in the field of legal settling has become increasingly broad.Specialists are giving increasingly more consideration to the securing of modular proof. This paper proposes the development of a component examination model for modular proof examination applications. The technique for this paper is to apply the guileless Bayes strategy, propose a superior information mining calculation, and lay out a model for proof observation and examination. The function of these methods is to systematically explore the basic theoretical issues of demeanor evidence based on the status quo of judicial application of demeanor evidence. Through the prediction of individual demeanor based on data mining algorithm, the evidence analysis model is designed, the neurobiological experiment is carried out, and the demeanor evidence animal stress model is constructed to verify the scientific basis of multidemeanor evidence observation. The experimental results showed that after repeated stimulation of SD rats, the maximum changes in the expression of HSP70 gene and SAA gene were 10.77 and 14.1 respectively, reflecting the high reliability of demeanor evidence biological experiments.
Effect of Grandivittin from Ferulago trifida Boiss. on the proliferation and apoptosis of human lung cancer A549 cells
Authors: Anbaji Fatemeh Zomorodi , Zargar Seyed Jalal , Tavakoli Saeed
Published: December 2022

Lung cancer is one of the deadliest cancers in the world. Introducing new promising agents can help the chemotherapeutic management of cancer. In the knowledge of oncology, plants are of special interest as a rich source of new antineoplastic and chemotherapeutic agents. Grandivittin (GRA) is one of the main constituents of Fenzl (Ferulago trifida Boiss.) with established medicinal, phytochemical, and pharmacological properties. This study aimed to evaluate the antineoplastic potential of GAR and its underlying mechanisms in human lung cancer A549 cells. The viability of the A549 cells after being treated with different concentrations of GRA for three following days was measured using the MTT method. The early and late apoptosis were assessed by fluorescence-activated cell sorter analysis through annexin V/PI staining. The expression of apoptotic agents' genes (caspase3, caspase 9, Bcl2, Bax, and P53 ) was evaluated by the RT-PCR method. The GRA increased apoptotic cells and decreased cell viability in a dose- and time-dependent manner, in which only 50% of cells survived at a dose of 0.7 mM. The expression of Bax, P53, Caspase3, and caspase 9 genes in the A549 cells was significantly up-regulated after GRA treatment compared to control cells (P < 0.05). On the other hand, the Bcl2 was significantly down-regulated after GRA treatment (P < 0.05). The results indicated that the GRA can activate cell death in A549 lung carcinoma cells by ‎inducing both DNA toxicity p53 and cascade-dependent pathways. Therefore, the GRA may be a potential new therapeutic agent for the treatment of lung cancer.
The effects of omega-3 fatty acid used maternal rations during pregnancy on the fattening performances of male kids
Authors: Erez ibrahim , Serbester Uğur
Published: December 2022

In this study, fish oil was used as an omega-3 fatty acids source in pregnant goat’s rations in the different periods of pregnancy on mature male offsprings performance. Forty-seven male goat kids (84.6 ± 2.44 days or days old; 14.5 ± 3.09 kg body weight) were housed in individual pens and to evaluate live weight, feed consumption, serum biochemical parameters, carcass performance and meat quality characteristics for 56 days. Supplementation of fish oil to Anaç goats dam ration during the gestation periods decreased the fattening live weight and increased feed consumption (p=0.09), while body weight and feed conversion rates were not affected by experimental treatments (p=0.62, p=0.90). Fish oil increased serum AST, glucose, total protein, and globulin concentrations (p=0.02, p=0.01, p=0.03, p=0.02), while decreased heptadecanoic acid, oleic acid, linoleic acid, docosahexaenoic acid, and total mono- and polyunsaturated fatty acid concentrations in M. longissimus dorsi muscle (p=0.09, p=0.03, p=0.10, p=0.02, p=0.02, p=0.09). As a result, it has been thought that the use of liquid fish oil as an omega-3 source in goat’s ration during gestation may negatively affect the fetal development of male kids, but it has the ability to eliminate this negativity by improving post-weaning performance.
An Experimental Study on the Effect of Graphite Microparticles on the Mechanical and Tribological Properties of Epoxy Matrix Composites
Authors: Ibrahim Muhammad Mustapha , El-Tayeb N. S.M , Shazly Mostafa , Seleman M. M. El-Sayed
Published: December 2022

In this article, mechanical and tribological properties of epoxy matrix composites filled with graphite particulates of 100µm at loadings between 0-1wt% were comprehensively discussed. The effects of the graphite filler on the wear surface of the specimens was investigated using an optical microscope. Results showed a large decrease in the tensile strength of the composite by more than 50% for 1wt% graphite loading. Flexural strength was seen to increase sharply with 0.1wt% graphite before reducing with higher graphite content. Impact and hardness values are both improved with higher graphite content. Friction coefficient was seen to reduce with the addition of graphite particles, this was attributed to the solid lubrication abilities of graphite. Wear rate was seen to sharply reduce with increase in graphite content as a result of the lubrication layer developed at the contact surface hence reducing the break-off of the specimen.
Validation of the Methods for the Non-milk Fat Detection in Artificially Adulterated Milk With Palm Oil
Authors: El-Nabawy Marwa , Awad Sameh , Ibrahim Amel
Published: December 2022

Dairy products are among the most adulterated food products. Because of the current high price of milk fat, it has been replaced by low-cost oils, especially those oils that have the same fatty acid profile as milk fat. This study aims to validate some classic methods, and the gas chromatography, reverse phase high performance liquid chromatography, and Fourier Transform infrared, to detect palm oil in milk and confirm the minimum levels of palm oil added to milk. Five treatments of fresh milk cream and an emulsion of palm oil were used to prepare different levels of palm oil in the final liquid milk. The results of this study showed that the values of the saponification number decreased with the increase in the percentages of added palm oil, but there was no decrease under the limits of the Egyptian standards until the addition of 25% palm oil. The iodine number is less sensitive than the saponification number in the detection of palm oil. Butyro refractometer reading is unable to detect the palm oil in milk. The fatty acid profile in milk determined by gas chromatography correlated well with the addition of palm oil. Furthermore, there is a positive relationship between the level of added palm oil and the cholesterol and β-sitosterol content as measured by reverse-phase high-performance liquid chromatography. There was no relationship between the behavior of the spectra resulting from Fourier transform infrared spectroscopy and the presence of palm oil.
AIUNet: A Medical Image Segmentation Network Composed of Attention and Inception Blocks
Authors: Huang Weiting , Zhao Xuejing , Li Jie , Ren Xinying , Xiong Diaohan , Zhang Jing , Hou Mengjiao
Published: December 2022

Background: Glioma is the most common brain tumor disease. Magnetic resonance can help the clinical diagnosis according to the location of the glioma and the degree of malignancy, in which the segmentation of glioma site plays an important role for clinicians. The work of manual segmentation is very time-consuming and cumbersome, therefore automatic and efficient segmentation methods are very necessary.
Methods: This paper proposed an AIUNet to give a more efficient segmentation of glioma, where a new block---Attention based Inception Block (AI Block), combining convolution and Self-Attention, is introduced. This module combines the smaller receptive field of convolution with the larger receptive field of Self-Attention, so as to extract more diverse feature maps to meet the needs of refined segmentation, and some deformations of AI block will be introduced and applied to the segmentation of glioma lesion. The AIUNet image segmentation network is constructed by merging AI block with the U-shaped network, this network has excellent segmentation performance, as well as low amount of parameters and calculation. Moreover, a loss function combined with GHM loss and Dice loss is plugged into the network, thereby improving the robustness of the network.
Results: Experiments show that the proposed network can improve segmentation effects comparing with state-of-the-art methods.
Kirkpatrick Evaluation Model to Assess a Training of English as a Media of Instruction
Authors: Zhao Wenlan , Liu Zixian , Sun Chunyan , Wang Tong
Published: December 2022

Background

English as a Media of Instruction (EMI) teacher development projects is based upon the framework for teacher Continuing Professional Development (CPD). To effectively improve both the confidence and overall capacity of EMI lecturers, the project applies the teaching excellence curriculum jointly developed by the British Council and Oxford University. Kunming Medical University(KMU) conducted the EMI lecturer development program to improve the teaching ability of the university's subject teachers to meet the requirement of excellent teaching for MBBS and achieve the goals of enhancing teaching quality and the internationalization level of the university. This paper aims to evaluate the effectiveness of the EMI training project, implemented at the KMU, via the Kirkpatrick Evaluation model.

Methods

The EMI training program at KMU embodies a three-stage instructor development program grounded firmly in classroom teaching practices. The effectiveness of the EMI training project was estimated in terms of the reaction, learning, and behavior dimensions based on the Kirkpatrick model. Project data were collected through a researcher-created questionnaire; the questionnaire survey was conducted online by Survey Monkey; while data analysis was implemented by SPSS statistical software 25.0.

Results

The mean age of 85 participants was 35 ± 8.5 years. All participants accomplished activities of overall training. The assessment of the first reaction level revealed an overall satisfaction rate of 100% for the whole training. The learning level revealed the average comprehension and mastery of the 10 learner-centered skills of EMI teaching was notably improved and found to be statistically significant (p < 0.00) compared among pre-training, after stage1, and after stage3. The behavior level showed that the trainee’s confidence as an EMI instructor increased dramatically from 28.12% after stage 1 to 82.55% after stage 3 (p < 0.05). Observations suggest that all participants engaged in learning the EMI methodology and that the knowledge gained from the training contributed positively to their behaviors, practices, and skills.
Conclusion: EMI training had a favorable impact on the progressive development of teachers at levels 1-3 of the Kirkpatrick evaluation model. It effectively contributed to a learner-centered approach to teaching and learning, along with the competence and confidence of instructors to teach EMI in a school context, which consequently exerted a potentially beneficial effect on the pedagogical quality of MBBS education.
Can ESG boost zombie firms back to normal: Evidence from Chinese firms
Authors: Ren Guangqian , Li Junchao , Zhao Mengjie , Liu Li , Zheng Minna , Jing Man
Published: December 2022

In recent years, the Chinese government has put forward sustainable development and reduced the negative macroeconomic impact of zombie firms. As a channel for firms to engage in green development, can ESG exert its value effect and help firms out of the zombie dilemma? This paper studies the impact of ESG on zombie firms and the influence mechanism by using data from China A-share listed companies from 2011 to 2019. While ESG requires firms to invest more externally, we find that ESG can also help zombie firms return to normal by increasing total factor productivity. The additional analysis finds that external funding support also plays an important role in mitigating ESG costs and better performing ESG functions. In addition, the positive effect brought by ESG is primarily driven by firms in eastern China, non-heavily polluting firms, and non-state-owned enterprises. These findings contribute to the burgeoning literature on ESG and provide implications for zombie firms’ governance and government policy.