bluuebunny/crossref_metadata_2025 huggingface dataset:
The smartphone addiction tendency and quality of life in students with disabilities
Authors: Lintin Lavenia , Huwae Arthur
Published: December 2022

This study aimed to determine the relationship between smartphone addiction and quality of life among students with disabilities. The method used was quantitative with a correlational design. The participants involved in this study were 33 students with disabilities chosen using snowball sampling. The research measurement used the Smartphone Addiction Scale (α = 0.943) and WHOQOL-BREF (α = 0.941). The results showed that there was no significant negative relationship between smartphone addiction and quality of life among students with disabilities (r = -0.238 and sig. = 0.091). These results indicate that the failure to achieve a quality of life for students with disabilities is not caused by smartphone addiction tendency. The use of smartphones can be controlled in a balanced way by students with disabilities in their daily activities so that it does not have a negative impact on their quality of life.
SEXUAL VIOLENCE AGAINST WOMEN DURING ARMED CONFLICTS: RUSSIAN AGGRESSION AGAINST UKRAINE AS AN EXAMPLE
Authors: Khater Maya
Published: December 2022

Background: Sexual violence is a significant issue that violates human rights and is a source of increasing concern for women during international and local armed conflicts. It has widespread impacts on civilian communities and on women in particular, with grave and long-lasting health, psychological, and social impacts. The descriptive analytical method was used to investigate and analyse laws prohibiting sexual assault against women, focusing on the role of international law in addressing these crimes. It was found that multiple international laws are in place to address this violence, but the enforcement of these laws requires work.
Methods: The descriptive-analytical method is used to investigate and analyse legal provisions prohibiting sexual violence against women. A set of recommendations is derived for how to limit and avoid the deterioration of such phenomena and to deal with it at legal, social, political, health, and other levels.
Results and Conclusions: Due to its consequences, which include physical, psychological, social, and economic complications, sexual assault is regarded as one of the most serious violations of human rights. The scarcity of judicial trials and prosecutions against perpetrators of this violence is considered to be a driving force behind these crimes.
Hasil Laboratorium Kelayakan Sumber Mata Air Cikoneng Kabupaten Garut
Authors: Nurputra Roby Ramda , Susetyaningsih Adi , Walujodjati Eko
Published: December 2022

Sumber mata air Curug Cikoneng merupakan jenis mata air kecil, sedangkan untuk tipe air nya merupakan tipe mata air rekahan yaitu muncul dari rekahan – rekahan batuan. Selama ini air dari sumber Curug Cikoneng belum dimanfaatkan sebagai sumber air baku bagi masyrakat desa Pasawahan secara optimal karena air yang mempunyai rasa asam. Penelitian ini bertujuan untuk mengetahui kualitas air yang bersumber dari mata air Curug Cikoneng sebagai kebutuhan penduduk di Desa Pasawahan Kecamatan Tarogong Kaler Kabupaten Garut Provinsi Jawa Barat. Metode yang digunakan adalah metode deskriptif dengan objek penelitian 1 sumber mata air di Desa Pasawahan Kaki Gunung Guntur. Teknik pengumpulan data dengan cara observasi, pengamatan, pengambilan sampel dibeberapa titik yaitu Jaba Tonggoh, Jaba Lebak dan PLP Citiis, pengujian sampel yang dilakukan di Laboratorium Kesda Garut dengan menggunakan acauan PERMENKES RI NO.492/MENKES/PER/IV/2010, menganalisa sampel dan wawancara. Hasil penelitian menunjukan pada ketiga sumber sampel 1 (Jaba Tonggoh) dan sampel 3 (PLP Citiis) airnya tidak berbau, mempunyai warna yang jernih dan tingkat kekeruhan dibawah batas maksimum, sedangkan sampel 2 (Jaba Lebak) airnya tidak berbau tetapi warnanya kuning muda dan mempunyai tingkat kekeruhan 32,38 NTU, namun untuk ketiga sampel mempunyai rasa asam. pH pada (sampel 1) 3,5, (sampel 2) 6,6 dan (sampel 3) 3,6. Kadar Fe (Besi) pada (sampel 1) 3,49 mg/l, (sampel 2) 0,63 mg/l dan (sampel 3) 0,61 mg/l. Kadar mangan pada (sampel 1) 0,63 mg/l, (sampel 2) 0,48 mg/l dan (sampel 3) 0,58 mg/l. Kadar Sulfat (sampel 1) 800 mg/l, (sampel 2) 520 mg/l dan (sampel 3) 790 mg/l. Jumlah bakteri coliform sampel 1 (15), sampel 2 (38) dan sampel 3 (≥240).  Dari hasil penelitian yang sudah dilakukan, mata air Curug Cikoneng tidak layak untuk dikonsusmsi.
Ankara İli Kalecik İlçesi topraklarının toprak etüdü, haritalanması ve sınıflandırılması
Authors: TUNÇAY Tülay , BAŞKAN Oğuz , DENGİZ Orhan , KEÇECİ Mehmet , USUL Mustafa
Published: December 2022

Bu araştırma, sürdürülebilir arazi kullanımı için, arazi ve toprak yönetim gereksinimi olan toprak verilerinin konumsal ve uluslararası standartlara uygun olarak elde edilmesi amacıyla yürütülmüştür. Bu çalışmada, Ankara ili Kalecik ilçesi topraklarının detaylı etüd ve haritalaması yapılmıştır. Toplam çalışma alanı 116.025 ha’dır. Yıllık ortalama sıcaklık 12.5°C ve yıllık toplam yağış ise 375 mm’dir. Bölgeye ait topoğrafik, jeolojik ve jeomorfolojik haritaların incelenmesi ve arazi gözlemleri sonucunda araştırma alanında 16 adet toprak profili açılmıştır. Detaylı arazi gözlemleri, grid yöntemi ve burgu yoklamaları ile gerçekleştirilmiştir. Açılan profillerin her birinden horizon esasına göre örnekler alınmış ve laboratuvarda analizleri yapılmıştır. Analizlerden elde edilen sonuçların ve arazi gözlemlerinin değerlendirilmesi ile 16 farklı toprak serisi tanımlanmıştır. Belirlenen toprakların 5 tanesi genç olmaları nedeniyle Entisol ordosuna, 5 tanesi Inceptisol ve 1 tanesi ise Vertisol ordolarına dâhil edilmişlerdir. Araştırma alanında %19.3 ile Hancılı serisi en fazla alana sahip iken %0.1 ile Karatepe serisi en az alana sahiptir.
Carotid Cavernous Fistula with Central Retinal Vein Occlusion
Authors: Kweon Ji-Min , Ahn Seong-Yeol , Yang Ji Ho , Kim Gye Jung , Lee Ju-Yeun
Published: December 2022

Purpose: To report a rare case of slow progression of carotid cavernous fistula (CCF) with central retinal vein occlusion (CRVO).Case summary: A 66-year-old man presented with conjunctival injection and proptosis in the right eye. Best-corrected visual acuity was 0.8 and 0.5 in the right and left eye, respectively, and conjunctival vessel enlargement and subconjunctival hemorrhage were observed in the right eye on slit lamp examination. Due to suspicion of CCF, computed tomography, computed tomography angiography, magnetic resonance imaging, and magnetic resonance angiography were performed. These analyses showed no vascular abnormalities associated with arteriovenous shunt, so the patient was followed up closely. About 1 month later, his conjunctival vessel engorgement became severe and CRVO derived from venous stasis by CCF occurred, so transfemoral cerebral angiography was performed and a diagnosis of CCF was made. Intravitreal anti-vascular endothelial growth factor injection was performed for CRVO, and best corrected visual acuity improved to 1.0 in the right eye.Conclusions: Slowly progressing CCF can be accompanied with rare intraocular disease, such as CRVO, so appropriate diagnosis through detailed evaluation is important for treatment.
Neurosyphilis: An Important Cause of Recurrent Strokes
Authors: Ghaznain Mohammad , Sutton-Fitzpatrick Una , Donnelly Mary-Teresa
Published: December 2022

Background: Neurosyphilis can manifest as recurrent brain infarction, although not frequently, but can be challenging to diagnose due to atypical presentations. Case report: A 43-year-old male with history of smoking presented to the Midland Regional Hospital, Tullamore (MRHT), Offaly, Ireland, with focal speech deficit and arm/leg weakness for 3 days. Neuroimaging showed acute cerebral infarction. He denied any high-risk sexual contacts. Forty-eight hour telemetry, trans-thoracic echocardiogram, cerebral catheter angiogram, and magnetic resonance angiogram were normal. He was treated with high-dose aspirin for 14 days and then discharged on aspirin with a follow-up plan. Trans-oesophageal echocardiogram performed after 2 weeks showed no evidence of subacute bacterial endocarditis, but there was evidence of fibroelastoma on the aortic valve. The cardiology department felt this was not a likely cardioembolic source. The patient presented 2 months later with recurrent stroke symptoms of loss of speech to another hospital. However, he was discharged for follow-up in MRHT as symptoms resolved. Brain computed tomography (CT) showed ‘old’ stroke. One week later he re-presented to MRHT with dysarthria, ataxia, and a National Institute of Health Stroke Scale (NIHSS) score of three. Repeated neuroimaging showed multiple ‘new’ and ‘old’ cerebral infarcts. The patient was anticoagulated based on recurrent thromboembolic events and magnetic resonance imaging was repeated. CT aortogram and 48-hour Holter results were normal. A repeated magnetic resonance angiogram showed multiple stenosis areas due to vasculitis. As aetiology was complex, a lumbar puncture was performed and blood tests repeated (viral serology, vasculitic and thrombophilia screens). Cerebrospinal fluid and serum analysis displayed a diagnosis of neurosyphilis with co-infection of HIV. Treatment with penicillin was commenced, after which the patient greatly improved and is now under long-term follow-up. Conclusion: Stroke in a young patient is rare and recurrent stroke-like events in a young person raise the clinical suspicion of an alternative diagnosis. It is therefore imperative to investigate neurosyphilis in all HIV-positive patients, as it can cause early clinical manifestation in such patients.
Pengolahan Limbah Cair Laboratorium Menggunakan Teknik Fotokatalisis Dengan TiO2
Authors: Adawiah Adawiah , Hanif Muhammad Rusydi , Setiawan Chepi , Alfatan Alfi , Apriliani Rika
Published: December 2022

Saat ini, universitas merupakan salah satu pelaku penggunaan zat kimia untuk tujuan pendidikan yang dilakukan pada praktikum-praktikum maupun penelitian. Berdasarkan survei lapangan, diketahui bahwa pengolahan limbah laboratorium terkhusus limbah cair organik yang dilakukan masih belum optimal. Hal ini perlu diperhatikan mengingat pada umumnya letak universitas berada di tengah pemukiman sehingga apabila limbah mencemari perairan tentu akan berisiko menimbulkan dampak serius bagi masyarakat. Suatu teknologi pengolahan limbah menggunakan bahan yang lebih maju yang dikenal sebagai fotokatalisis disebut mampu mengolah zat organik beracun menjadi zat yang lebih sederhana dan ramah lingkungan. Penelitian ini meliputi beberapa tahap yaitu pengumpulan data limbah yang dihasilkan dari kegiatan praktikum dan penelitian, pengambilan sampel limbah laboratorium, dan uji pengolahan limbah dan analisis kandungan total senyawa organik dari produk hasil pengolahan limbah titrasi permangnometri. Hasil penelitian menunjukkan bahwa fotokatalis TiO2 dengan komposisi 0,8% (b/v) memiliki hasil mampu memberikan penurunan kandungan senyawa organik dalam sampel limbah sebanyak 96,19027% dalam waktu reaksi selama 4 hari.
Penentuan Strategi Optimal Dengan Game Theory Pada Persaingan 3 Kuliner Bakso Di Galuh Mas Karawang
Authors: Harun Muhammad , Suseno Agustian
Published: December 2022

The culinary area located in Galuh Mas Karawang is a strategic area that is very busy and never empty of visitors. The purpose of this study was to determine the optimal strategy between the three meatball with chicken noodle culinary competitions, namely Baso Ambon, Baso Malang and Baso Sopo Nyono. The research sample was 167 respondents who were only visitors and direct customers from the three meatball culinary places in March 2021. Based on the results of data processing with this method, it is found that the optimal strategy between Baso Malang and Baso Ambon has a meeting point of maximum value equal to the minimum value called a saddle point of 0.067 on row X2 and column Y1 which means Baso Malang uses a better service strategy than Baso Ambon. Meanwhile, Baso Ambon uses a more affordable price strategy than Baso Malang. Then for Baso Sopo Nyono and Baso Ambon have a saddle point of 0.284 on row X3 and column Y1, meaning that Baso Sopo Nyono uses a more complete facilities strategy than Baso Ambon.
Perencanaan Tata Letak Fasilitas Mesin Produksi Menggunakan Metode Activity Relationship Chart(Arc) Di CV. Yasri Cipta Mandiri
Authors: Rokhmani Eka Wahyu , Desiyanto Fanni , Harsadi Indrato
Published: December 2022

CV. Yasri Cipta Mandiri ini merupakan CV yang bediri tahun 2018, sebelumnya industri ini merupakan industri trading filter polimer yang saat ini memulai untuk memproduksi filter polimer sendiri, perusahaan ini memproduksi Filter Polimer. pada CV. Yasri Cipta Mandiri didapatkan proses produksi yang kurang dari segi Tata letak mesin produksi atau layout yang kurang efisien dalam derajat kedekatan sehingga jarak memiliki dampak kurang baik terhadap proses produksi pada CV. Yasri Cipta Mandiri serta ditambah akan datangnya 1 unit mesin baru stamping machine maka dari itu perlunya perbaikan tata letak fasilitas mesin produksi. Untuk perencanaan tata letak fasilitas mesin produksi menggunakan metode Activity Relationship Chart. Total jarak material handling atau jarak total dari tiap-tiap mesin sebesar 38,8 meter sebelum dilakukan penelitian. Setelah dilakukannya pengolahan data dan menempatkan stasiun kerja sesuai tingkat derajat kedekatan menggunakan metode activity realationship chart dihasilkan dua layout usulan dimana kedua layout usulan ini telah dapat meninimasi jarak antar stasiun kerja, layout usulan I didapatkan total jarak material handling sebesar 22,25 meter dan memperoleh nilai efisiensi 42,65 %, layout usulan II didapatkan total jarak meterial handling sebesar 20,46 meter dan memperoleh nilai efisiensi 47,26 %, sehingga layout usulan II direkomendasikan sebagai layout usulan yang terpilih.
Redesain Kursi Kuliah Ergonomis Menggunakan Pendekatan Antropometri Pada Program Studi Teknik Industri Universitas Islam Syekh Yusuf Tangerang
Authors: Hadiyansyah Febi , Juhara Sutresna , Rahayu Monita
Published: December 2022

Kursi merupakan salah satu alat penunjang aktivitas perkuliahan di Teknik Industri UNIS Tangerang. Berdasarkan Nordic Body Map yang telah dibagikan kepada mahasiswa Teknik Industri UNIS, didapat beberapa keluhan yang dirasakan mahasiswa disaat menggunakan kursi kuliah yang saat ini digunakan. Keluhan tersebut berupa rasa pegal atau nyeri pada bagian anggota tubuh antara lain pada bagian leher, punggung, pinggang, kaki, tangan kanan serta bokong. Hal tersebut menandakan jika desain kursi kuliah yang saat ini digunakan belum sesuai dengan antropometri para mahasiswa Teknik Industri UNIS. Metode penelitian ini menggunakan pendekatan antropometri dengan mengambil data antropometri mahasiswa lalu mengidentifikasi kursi kuliah yang digunakan saat ini. Tahap selanjutnya mengenai pengolahan data antropomteri, memasukan keinginan mahasiswa berdasarkan tingkat kepentingan dalam perancangan desain. Hasil penelitian didapatkan rancangan ulang kursi kuliah dengan desain baru yang minimalis dan mempunyai kelebihan yaitu sandaran kursi dan alas duduk telah menggunakan material busa sehingga lebih nyaman, terdapat rak penyimpanan barang atau buku, dan terdapat gantungan untuk menaruh tas pada bagian belakang kursi. Hasil rancangan ulang kursi kuliah sudah dapat mengurangi keluhan pengguna dengan memperbaiki sudut kemiringan pada sandaran kursi dan alas duduk.
The Effect of Operating Condition on Low Pressure Steam (LPS) in Sugar Factory by Pinch Analysis
Authors: Riadi Indra , Puji Utomo Dani
Published: December 2022

In the present work the sugar plant in Sragen, Central Java, Indonesia has ten evaporators that can be configured to five effect evaporators. The optimization ofenergy demand, finding optimum operating condition of LowPressure Steam (LPS), and choosing the best configuration of multiple effect evaporator (MEE) were performed by pinch analysis. In this paper, LPS at 0.4 kg/cm2.G – 1.1 kg/cm2.G were evaluated. The results show that the optimum operating condition of LPS was at 0.9 kg/cm2.G – 1.1 kg/cm2.G. This optimum operating condition enhances the energy saving by about 30% compared to that of existing plant (0.4 kg/cm2.G). The best performance value that can be achieved were Steam on Cane (SOC) by 43.50% and Steam Economy (SE) by 2.1
Analisa Permasalahan Sticking Pada Tablet XYZ Menggunakan Metode PDCA di PT. Sunthi Sepuri
Authors: Mashabai Ismi , Ruspendi Ruspendi , Syauqi Muhamad Iqbal
Published: December 2022

Analysis of the sticking problem on the xyz tablet using the PDCA method at PT. Sunthi Sepuri. Products that have a good level of quality will certainly get its own value for consumers. That's why the quality of a product is a measure of the success of a product.. Every company must carry out activities in its business and every activity has certain goals to be achieved as the direction of the implementation of its activities. To achieve this goal, it is necessary to control and supervise the day-to-day operations of the company's business. PT. Sunthi Sepuri is one of the companies in Tangerang that produces pharmaceutical products or known as pharmaceutical manufacturers and PT. Sunthi Sepuri is a subsidiary of Nugra Santana Group. During the product production process, there must be imperfections in producing tablets, resulting in defects in tablets. Problems with tablets include black spots, sticking (clots), capping (broken/split), variations in weight and variations in hardness. Based on observations for one month, the most defect problem in XYZ tablets is sticking. Fishbone Diagram is a problem solving technique that helps to think through the many possible causes of a problem to be solved. And PDCA is a model for continuous improvement by planning, doing, checking, and taking action. By finding the root cause of product defects and making continuous improvements, it is hoped that the company's products can improve
Analisis Persediaan Bahan Material Aspal Menggunakan Alat Stone Crusher dengan Metode RCCP
Authors: Mahmud Gustamin , Saputra Arie
Published: December 2022

PT Wirataco Mitra Mulia (WMM) adalah perusahaan yang bergerak di bidang kontruksi penghancur batu (stone srusher) seperti split ¾, medium ½, dan abu batu. Permasalahan yang sering terjadi pada umumnya di perusahaan-inisalah satunya adalah tidak terpenuhi permintaan dari konsumen, dimana persedian produksi tidak memenuhi permintaan dari konsumen. Tujuan Penelitian ini adalah untuk menganalisis persediaan bahan material aspaldi PT. Wirataco Mita Mulia. RCCP merupakan metode yang digunakan menganlisisa kapasitas persediaan produksi dalam memenuhi kebutuhan kapasitas permintaan produksi sekaligus membuat jadwal induk prodksi (JIP), menghitung efesiensi, dan menghitung utilitas . Kapasitas mesin 1 hari kerja 8 jam dan 1 shift kerja, 1 minggu = 6 hari kerja, 1 bulan = 24 hari kerja. Waktu tersedia per bulan = 24 hari kerja. Perbandingan yang dilakukan setelah penelitian bahwasanya kapasitas perintaan split ¾ = 10560 M3 sedabgkan kapasitas tersedia = 14668 M3. Kapasitas permintaan medium ½ = 7447, sedangkan kapasitas tersedia = 13979 M3. Untuk kapasitas permintaan abu batu = 7092 M3 sedangkan kapasitas tersedia = 3416 M3,  Artinya, kapasitas persediaan split ¾ dan medium ½ terpenuhi. Sedangkan permintaan produksi abu batu tidak terpenuhi. Untuk itu, perusahaan sudah sebaiknya melakukan perencaanaan produksi berdasarkan jadwal induk produksi dan RCCP, sehingga persediaan abu batu dapat terpenuhi.
Türkiye’de Yönetimsel Aklın İnşası: I. Aile Şûrası Kararları’nın Analizi
Authors: TUZCUOĞLU Beyhan Çağrı
Published: December 2022

1980’lerin başından itibaren Türkiye kapsamlı bir ekonomik ve siyasal dönüşüm sürecine girmiştir. Bu dönüşümün temeli, Foucault’nun yönetimsellik (governmentality) adını verdiği yeni yönetim biçimini adapte etme çabasıdır. Özellikle Batı ülkelerinde büyük oranda yerleşmiş olan bu yeni yönetim biçimine geçmek için bu örnekler de incelenerek önemli reformlara girişilmiş ve birçok yeni kurum oluşturulmuştur. Bu kurumlardan ikisi olan Aile Araştırma Kurumu ve Aile Şûrası koordineli bir şekilde çalışarak bu dönüşümde önemli bir işlev görmüş, bu dönüşümün yol haritasını çıkarmak misyonunu üstlenmişlerdir. Bu makalenin iddiası, adı bu şekilde konulmasa da, Aile Şûrası raporlarında ortaya konulan temel meselenin Türkiye’nin yönetimsel iktidar tekniklerini nasıl adapte edeceği sorunu olduğu ve üretilen politika ve projelerin yönetimselliğe geçiş için bir yol haritası şeklinde kurgulandığıdır. Bu çalışmada, 1990 yılında toplanan I. Aile Şûrası kararları üzerinden bir söylem analizi yapılarak Türkiye’de bu yeni yönetimsel aklın inşa edilme sürecinin başlangıç aşaması incelenecektir. Bu çalışmanın temel sorusu, bu yeni yönetim anlayışına geçişin nasıl planlandığı ve bu geçiş için hangi iktidar mekanizmalarının kullanılmasının önerildiğidir.
Analysis of Variations in the Basic Indicators of Mini Pigs under Extreme Physical Exertion
Authors: Stankova N. V. , Alimkina O. V. , Pomytkin I. A. , Karkischenko V. N.
Published: December 2022

Extreme physical exertion (work to failure) was simulated in untrained mini pigs. The results of complete blood tests, lactate measurements and clinical urine analysis revealed variations in the basic parameters of animals similar to those observed in people after extreme exertion.
Kajian Pustaka Potensi Sargassum Sp. Sebagai Nutrasetikal
Authors: Aryatikta Reyhan , Sri Winarni  , Susatyo Nugroho Widyo Pramono
Published: December 2022

Sargassum sp. adalah salah satu jenis rumput laut yang banyak terdapat di Indonesia. Analisis kimia dan studi eksperimen telah menunjukkan potensi Sargassum sp. sebagai nutrasetikal, dengan temuan berbagai senyawa bioaktif yang memiliki manfaat kesehatan. Kajian ini bertujuan untuk merangkum literatur yang ada mengenai Sargassum sp., yang ditinjau dari kandungan senyawa bioaktif dan komposisi kimia serta efeknya terhadap kesehatan.  Berdasarkan hasil penelusuran literatur, ditemukan bahwa Sargassum sp. memiliki senyawa bioaktif, seperti fukoidan, laminarin, alginat, fukosterol, phlorotanin, sargachromenol, dan fukosantin. Senyawa-senyawa ini memiliki fungsi sebagai antioksidan, antiinflamasi, antidiabetik, antiobesitas, antimikroba, immunomodulator, sitoprotektan, gastroprotektan, dan neuroprotektan. Oleh karena itu, Sargassum sp. berpotensi untuk dikembangkan lebih lanjut sebagai nutraseutikal.
Part-of-Speech and Morphological Tagging of Algerian Judeo-Arabic
Authors: Tirosh-Becker Ofra , Kessler Michal , Becker Oren , Belinkov Yonatan
Published: December 2022

Most linguistic studies of Judeo-Arabic, the ensemble of dialects spoken and written by Jews in Arab lands, are qualitative in nature and rely on laborious manual annotation work, and are therefore limited in scale. In this work, we develop automatic methods for morpho-syntactic tagging of Algerian Judeo-Arabic texts published by Algerian Jews in the 19th--20th centuries, based on a linguistically tagged corpus. First, we describe our semi-automatic approach for preprocessing these texts. Then, we experiment with both an off-the-shelf morphological tagger and several specially designed neural network taggers. Finally, we perform a real-world evaluation of new texts that were never tagged before in comparison with human expert annotators. Our experimental results demonstrate that these methods can dramatically speed up and improve the linguistic research pipeline, enabling linguists to study these dialects on a much greater scale.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT PENGETAHUAN MASYARAKAT TENTANG KERACUNAN MAKANAN DI KECAMATAN ALUH-ALUH
Authors: Wahana Hijratun
Published: December 2022

Latar Belakang : Keracunan makanan merupakan salah satu masalah kegawatdaruratan yang menyebabkan kematian. Pengetahuan masyarakat dalam penanganan prehospital sangat penting, dikarenakan pengetahuan merupaka ujung tombak dalam perilaku sehat masyarakat. Pengetahuan mungkin dipengaruhi oleh usia, jenis kelamin, pendidikan, pekerjaan, sumber informasi  dan pengalaman Tujuan : Untuk menganalisis faktor-faktor yang berhubungan dengan tingkat pengetahuan masyarakat tentang keracunan makanan di Kecamatan Aluh-Aluh. Metode: Desain penelitian analitik korelasi dengan pendekatan cross sectional. Sampel berjumlah 100 responden dengan menggunakan cluster random sampling. Instrument penelitian menggunakan kuesioner yang dianalisis secara univariat menggunakan distribusi frekuesi yang disajikan dengan table dan bivariat dengan uji Pearson Chi square. Hasil : Faktor usia, jenis kelamin, pendidikan, pekerjaan dan pengalaman tidak terdapat hubungan yang signifikan dengan tingkat pengetahuan dengan ρ value>0.05) dan terdapat  hubungan yang signifikan antara sumber informasi dengan tingkat pengetahuan dengan ρ value = 0.000 (ρ value<0.05). Kesimpulan : Faktor yang berhubungan dengan pengetahuan adalah sumber informasi.
THE EFFECTS OF FOOT GIVING MASSAGE OF LIMBS TO A DECREASED SCALE OF FATIGUE IN HEART FAILURE IN PATIENTS HOSPITAL X
Authors: Julianto Julianto , Yuniarti Yuniarti , Mariana Mariana
Published: December 2022

Gagal jantung merupakan dimana jantung sebagai pompa yang tidak mampu memenuhi kebutuhan darah untuk metabolisme jaringan disebabkan bertambahnya usia. Kelelahan sering dialami oleh penderita gagal jantung. Terapi yang diberikan farmakologi dan non farmakologi dengan terapi komplementer seperti massage tungkai. Penelitian ini bertujuan untuk mengetahui Pengaruh Pemberian Massage Tungkai Terhadap Penurunan Skala Kelalahan Pada Pasien Gagal Jantung. Metode eksperemen yang menggunakan pendekatan atau rancangan one-group pre-post tes design. Jumlah sampel penelitian yaitu 20 pasien kelelahan pada gagal jantung yang mengalami kelelahan. Hasil penelitian ini sebelum dilakukan massage tungkai didapat nilai 0,370, sesudah dilakukan massage tungkai dapat nilai signifikan 0,558. Hasil p-value (0,000) < α (0,05) sehimgga telihat adanya penurunan massage tungkai pada pasien gagal jantung.
Limitations of current chemotherapy and future of nanoformulation-based AmB delivery for visceral leishmaniasis—An updated review
Authors: Kumar Prakash , Kumar Pawan , Singh Nidhi , Khajuria Salil , Patel Rahul , Rajana Vinod Kumar , Mandal Debabrata , Velayutham Ravichandiran
Published: December 2022

Graphical Abstract

The nanoparticles with different size, shape and structure for drug delivery against Leishmania donovani.
Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models
Authors: Wegner Christina Henriette , Hubbuch Jürgen
Published: December 2022

When developping selective crystallization or precipitation processes, biopharmaceutical modalities require empirical screenings and analytics tailored to the specific needs of the target molecule. The multi-way chemometric approach called parallel factor analysis (PARAFAC) coupled with ultraviolet visible light (UV/Vis) spectroscopy is able to predict specific concentrations and spectra from highly structured data sets without the need for calibration samples and reference analytics. These calculated models can provide exploratory information on pure species spectra and concentrations in all analyzed samples by representing one model component with one species. In this work, protein mixtures, monoclonal antibodies, and virus-like particles in chemically defined and complex solutions were investigated in three high-throughput crystallization or precipitation screenings with the aim to construct one PARAFAC model per case. Spectroscopic data sets of samples after the selective crystallization or precipitation, washing, and redissolution were recorded and arranged into a four-dimensional data set per case study. Different reference analytics and pure species spectra served as validation. Appropriate spectral preprocessing parameters were found for all case studies allowing even the application of this approach to the third case study in which quantitative concentration analytics are missing. Regardless of the modality or the number of species present in complex solutions, all models were able to estimate the specific concentration and find the optimal process condition regarding yield and product purity. It was shown that in complex solutions, species demonstrating similar phase behavior can be clustered as one component and described in the model. PARAFAC as a calibration-free approach coupled with UV/Vis spectroscopy provides a fast overview of species present in complex solution and of their concentration during selective crystallization or precipitation, washing, and redissolution.
Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefit
Authors: Groves Andrew , Cooney Tabitha M.
Published: December 2022

Pediatric high-grade gliomas (pHGG) are a molecularly diverse group of malignancies, each incredibly aggressive and in dire need of treatment advancements. Genomic analysis has revolutionized our understanding of these tumors, identifying biologically relevant subgroups with differing canonical mutational profiles that vary based on tumor location and age. In particular, the discovery of recurrent histone H3 mutations (H3K27M in diffuse midline glioma, H3G34R/V in hemispheric pediatric high-grade gliomas) as unique “oncohistone” drivers revealed epigenetic dysregulation as a hallmark of pediatric high-grade gliomas oncogenesis. While reversing this signature through epigenetic programming has proven effective in several pre-clinical survival models, early results from pediatric high-grade gliomas clinical trials suggest that epigenetic modifier monotherapy will likely not provide long-term disease control. In this review we summarize the genetic, epigenetic, and cellular heterogeneity of pediatric high-grade gliomas, and highlight potential paths forward for epigenetic programming in this devastating disease.
Power optimization control of VSC-HVDC system for electromechanical oscillation suppression and grid frequency control
Authors: Bi Chaohao , Wu Jiaqi , Qian Yang , Luo Xin , Xie Jianxiang , Shi Jianquan , Luo Fang
Published: December 2022

The voltage source converter (VSC) based high-voltage DC (HVDC) transmission system usually adopts damping and inertia control to quickly and independently adjust the active- and reactive- power, to improve the frequency stability and suppress the electromechanical oscillations of the power grid. This paper first analyzes the effect of the proportional-derivative (PD) controller parameter on the HVDC output power. The study shows that when the proportional-derivative controller parameter is increased to the limit value, HVDC will operate in the rapid power compensation (RPC) mode. Namely, according to the positive or negative polarities of the rotor speed deviation and the grid frequency deviation, the active- and reactive- power limits are used as the reference to rapidly control the output power, thereby minimizing the system’s unbalanced power, the rotor oscillation, and the frequency fluctuation. To this end, this paper proposes a coordinated active-/reactive- power control strategy for the VSC-HVDC system based on the RPC mode to suppress the grid electromechanical and frequency oscillations. The RPC mode enables HVDC to quickly release/absorb power, to compensate for system’s required power shortage or suppress excess power. When the speed deviation, the frequency deviation, and their rates of change meet the requirements, the damping control is used to make HVDC exit the RPC mode and further enhance the ability of the VSC-HVDC system. Simulation results prove the effectiveness of the proposed power optimization control strategy.
The relationship between prenatal exposure to organophosphate insecticides and neurodevelopmental integrity of infants at 5-weeks of age
Authors: Sittiwang Supattra , Nimmapirat Pimjuta , Suttiwan Panrapee , Promduang Wathoosiri , Chaikittipornlert Nattapon , Wouldes Trecia , Prapamontol Tippawan , Naksen Warangkana , Promkam Nattawadee , Pingwong Sureewan , Breckheimer Adrian , Cadorett Valerie , Panuwet Parinya , Barr Dana Boyd , Baumert Brittney O. , Ohman-Strickland Pamela , Fiedler Nancy
Published: December 2022

Introduction

Organophosphate (OP) insecticides are among the most abundantly used insecticides worldwide. Thailand ranked third among 15 Asian countries in its use of pesticides per unit hectare and fourth in annual pesticide use. More than 40% of Thai women of childbearing age work on farms where pesticides are applied. Thus, the potential for pregnant women and their fetuses to be exposed to pesticides is significant. This study investigated the relationship between early, mid, and late pregnancy maternal urine concentrations of OP metabolites and infant neural integrity at 5 weeks of age.

Method

We enrolled women employed on farms from two antenatal clinics in the Chiang Mai province of northern Thailand. We collected urine samples monthly during pregnancy, composited them by early, mid and late pregnancy and analyzed the composited samples for dialkylphosphate (DAP) metabolites of OP insecticides. At 5 weeks after birth, nurses certified in use of the NICU Network Neurobehavioral Scale (NNNS) completed the evaluation of 320 healthy infants. We employed generalized linear regression, logistic and Poisson models to determine the association between NNNS outcomes and DAP concentrations. All analyses were adjusted for confounders and included creatinine as an independent variable.

Results

We did not observe trimester specific associations between DAP concentrations and NNNS outcomes. Instead, we observed statistically significant inverse associations between NNNS arousal (β = −0.10; CI: −0.17, −0.002; p = 0.0091) and excitability [0.79 (0.68, 0.92; p = 0.0026)] among participants with higher average prenatal DAP concentrations across pregnancy. We identified 3 NNNS profiles by latent profile analysis. Higher prenatal maternal DAP concentrations were associated with higher odds of being classified in a profile indicative of greater self-regulation and attention, but arousal and excitability scores below the 50th percentile relative to US normative samples [OR = 1.47 (CI: 1.05, 2.06; p = 0.03)]. Similar findings are also observed among infants with prenatal exposure to substances of abuse (e.g., methamphetamine).

Discussion

Overall, the associations between prenatal DAP concentrations and NNNS summary scores were not significant. Further evaluations are warranted to determine the implications of low arousal and excitability for neurodevelopmental outcomes of attention and memory and whether these results are transitory or imply inadequate responsivity to stimulation among children as they develop.
Identification of familial networks reveals sex-specific density dependence in the dispersal and reproductive success of an endangered ungulate
Authors: McFarlane Samantha , Manseau Micheline , Jones Teri B. , Pouliot Darren , Mastromonaco Gabriela , Pittoello Gigi , Wilson Paul J.
Published: December 2022

Density is an important demographic parameter that is commonly overlooked in studies of wild populations. Here, we examined the effects of variable spatially explicit density on a range of demographic parameters in a wild population of a cryptic ungulate, boreal woodland caribou (Rangifer tarandus caribou). Using non-invasive genetic sampling, we applied spatial capture–recapture methods with landscape covariates to estimate the density of boreal woodland caribou across a 108,806 km2 study area. We then created a familial network from the reconstructed parent–offspring relationships to determine whether spatial density influenced sex-specific individual reproductive success, female pregnancy status, and dispersal distance. We found that animal density varied greatly in response to land cover types and disturbance; animal density was most influenced by landscape composition and distance to roads varying from 0 in areas with >20% deciduous cover to 270 caribou per 1,000 km2 in areas presenting contiguous older coniferous cover. We found that both male and female reproductive success varied with density, with males showing a higher probability of having offspring in higher-density areas, and the opposite for females. No differences were found in female pregnancy rates occurring in high- and low-density areas. Dispersal distances varied with density, with offspring moving shorter distances when parents were found in higher-density areas. Familial networks showed lower-closeness centrality and lower-degree centrality for females in higher-density areas, indicating that females found in higher-density areas tend to be less broadly associated with animals across the range. Although high-density areas do reflect good-quality caribou habitat, the observed decreased closeness and degree centrality measures, dispersal rates, and lower female recruitment rates suggest that remnant habitat patches across the landscape may create population sinks.
Association of lncRNA H19 polymorphisms with cancer susceptibility: An updated meta-analysis based on 53 studies
Authors: Yuan Yingying , Wang Yachun , Niu Xiaodong , Han Yungang , Li Wenbo , Cheng Meijin , Li Zheng , Tan Jiao , Zhao Yue , Wang Wei
Published: December 2022

The association between polymorphisms in lncRNA H19 and cancer susceptibility remains to be inconsistent. This study aimed to provide a more precise estimation of the relationship between lncRNA H19 polymorphisms and the risk of cancer based on all available published studies. 53 studies encompassing 32,376 cases and 43,659 controls were included in our meta-analysis by searching the Pubmed, Embase, Web of Science, WanFang, and China National Knowledge Infrastructure databases. Pooled ORs and their 95% CIs were used to estimate the strength between the SNPs in H19 (rs217727, rs2839698, rs2107425, rs3024270, rs2735971, rs3741216, and rs3741219) and cancer susceptibility. The results showed that H19 rs2839698 polymorphism was associated with increased cancer risk in all participants under three genetic models. However, no significant association was identified between the other six SNPs as well as an overall cancer risk. Stratification by ethnicity showed that rs2839698 mutation indicated to be an important hazardous factor for the Asian population. While rs2107425 mutation had a protective effect on the Caucasian population. Stratification by cancer type identified that rs217727 mutation was linked to increased susceptibility to oral squamous cell carcinoma, lung cancer, and hepatocellular carcinoma; whereas rs2839698 mutation was associated with an elevated risk of hematological tumor and digestive system tumor (p< 0.05). Besides, the rs2735971 mutation was connected with the digestive system tumor. In summary, the rs217727, rs2839698, rs2107425 and rs2735971 polymorphisms in H19 have associations with cancer susceptibility.
Successful treatment of dupilumab in Kimura disease independent of IgE: A case report with literature review
Authors: Yang Boyun , Yu Hanxiao , Jia Minyue , Yao Wo , Diao Ran , Li Bohui , Wang Yongfang , Li Ting , Ge Liuya , Wang Huiying
Published: December 2022

Kimura disease (KD) is a rare and benign chronic inflammatory disease of unknown cause. It is characterized by subcutaneous granuloma of soft tissues in the head and neck region, increased eosinophil count, and elevated serum IgE. Currently, no definitive treatments are recommended. A 57-year-old Chinese man was diagnosed with KD after 7 years of slow subcutaneous masses growth. The patient underwent treatment of oral glucocorticoids for 1 year, but the masses recurred as the dosage was tapered down. Subsequent anti-IgE therapy of omalizumab administered subcutaneously at 450 mg/day at a 4-week interval did not show improvement. The size of masses and serum IgE and circulating eosinophils did not decrease significantly after 19 cycles of continuous treatment. Ultimately, switched strategy of dupilumab was applied at an initial dose of 600 mg, followed by 300 mg every 2 weeks for 4 months. This treatment demonstrated dramatical effects with reduced masses in each area and fast dropdown of eosinophil counts, while the high level of serum IgE remained without changes. Recently, different biologics including anti-IgE, anti-IL-5, and anti-IL-4/IL-13 have been applied to treat KD with satisfied results and help to explore the pathogenesis of this rare disease. To our knowledge, this is the first report that demonstrates the effects of two different biologics in the same patient and reveals the impressive clinical efficacy of dupilumab to treat KD independent of IgE. Therefore, further investigation of the underlying mechanism and the development of diagnosis and treatment of KD is valuable.
Ten-year population trends of immunoglobulin use, burden of adult antibody deficiency and feasibility of subcutaneous immunoglobulin (SCIg) replacement in Hong Kong Chinese
Authors: Kan Andy Ka Chun , Leung Garret Man Kit , Chiang Valerie , Au Elaine Yuen Ling , Lau Chak Sing , Li Philip Hei
Published: December 2022

Background

Adult antibody deficiency remains under-recognised and under-studied – especially among Asian populations. Patterns of immunoglobulin use and the feasibility of subcutaneous immunoglobulin (SCIg) replacement among Chinese patients remains unclear.

Objective

To investigate the trends of immunoglobulin use, burden of adult antibody deficiency and the outcomes of patients on SCIg compared to intravenous immunoglobulin (IVIg) replacement in Hong Kong through a retrospective observational study.

Methods

Population-wide data of immunoglobulin recipients in Hong Kong between 2012 and 2021, and longitudinal clinical data of adult immunodeficiency patients at Queen Mary Hospital were collected and analysed.

Results

Total immunoglobulin consumption and recurrent immunoglobulin recipients increased continuously from 175,512g to 298,514g (ρ=0.99, p<0.001) and 886 to 1,508 (ρ=0.89, p=0.001) between 2012-21 in Hong Kong. Among 469 immunoglobulin recipients at Queen Mary Hospital in 2021, 344 (73.3%) were indicated for replacement. Compared to those on IVIg (n=14), patients on SCIg replacement (n=8) had fewer immunodeficiency-related hospitalisations (IRR=0.11) and shorter duration of hospitalisation stay (IRR=0.10) per year, as well as better quality of life (SF-36v2 Health Survey and Life Quality Index). Estimated annual healthcare cost of SCIg replacement per patient was lower than that of IVIg (HKD196,850 [USD25,096] vs HKD222,136 [USD28,319]).

Conclusion

There was a significantly increasing burden of adult antibody deficiency and immunoglobulin consumption in Hong Kong. SCIg was feasible and more cost-effective when compared to IVIg, with SCIg patients experiencing better clinical outcomes and quality of life. Future prospective studies to confirm the long-term efficacy and superiority of SCIg are required.
Distress as a mediator for pain and activities of daily living in older adults with fibromyalgia
Authors: Gower Caitlin , Trevitt Jennifer , Cherry Barbara J. , Zettel-Watson Laura
Published: December 2022

Introduction

Pain, distress, and activities of daily living impact the lives of those with chronic pain. This study investigated distress (depressive symptoms, anxiety) on the relationship between pain (intensity and pain interference) and activities of daily living in individuals with fibromyalgia while controlling for age.

Methods

The current cross-sectional investigation focused on data from 123 men and women with fibromyalgia. Pain intensity, pain interference and anxiety were measured on 0-10 Likert type scales from the National Fibromyalgia Assessment Questionnaire. Depressive symptoms were assessed using the Beck Depression Inventory II. Activities of daily living (basic, instrumental) were measured with the Physical Activity Inventory Scale.

Results

It was hypothesized that the relationships between pain intensity and pain interference and activities of daily living in individuals with fibromyalgia would be mediated by the construct of distress while controlling for age. Mediation significantly occurred in both models as predicted. However, those who were older reported lower levels of pain intensity and distress than their younger counterparts, which may be related to time since diagnosis or other factors.

Discussion

Results of this study suggest that individuals with chronic pain conditions would benefit from treatment options which address distress, specifically depressive symptoms and anxiety.
Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey
Authors: Bowden Rodney G. , Richardson Kathleen A. , Richardson Luke T.
Published: December 2022

Introduction

Hyperuricemia commonly associated with Gout has been proposed as an independent risk factor for Metabolic Syndrome (MetS).

Objective

The purpose of the study was to determine if there is a relationship between hyperuricemia and MetS.

Methods

An analysis of cross-sectional data was conducted using the 2013–2018 National Health and Nutrition Examination Survey (NHANES) datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized United States (US) civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens.

Results

Pearson’s correlations, chi-square tests, and logistic regression equations were calculated to determine the association between hyperuricemia and MetS. In an unadjusted regression analysis, individuals with hyperuricemia (above 7.0 mg/dL in males and 6.0 mg/dL in females) were 3.19 times more likely to have MetS compared to those with normal uric acid (UA) levels. When controlling for various confounding variables those with hyperuricemia were 1.89 and 1.34 times more likely to have MetS than those with normal UA levels in two additional logistic regression models.

Conclusion

In this large cross-sectional study, hyperuricemia was found to be associated with MetS. Additional analyses that controlled for various risk factors previously identified as predictive of MetS still demonstrated hyperuricemia independently associated with MetS. The results of this study suggest a need to understand the metabolic pathways of UA more clearly to further explain the contribution to MetS. Additional research should include prospective clinical trials assessing the effects of UA and the control of UA on MetS and concomitant medical outcomes.