bluuebunny/crossref_metadata_2025 huggingface dataset:
From molecular mechanisms to precision medicine: Transformative approaches in cirrhosis management
Authors: Addissouky Tamer A.
Published: February 2025

Background: Cirrhosis represents a major global health burden, driven by rising prevalence of risk factors like viral hepatitis, alcohol abuse, and obesity.
Purpose: This paper reviews current understanding of cirrhosis pathogenesis, limitations of traditional therapies, and recent revolutionary innovations in disease management.
Main Body: Chronic liver injury triggers inflammation and activation of hepatic stellate cells, key drivers of fibrosis. Resulting architectural distortions impair liver function. While conventional treatments like dietary modifications provide temporary relief, they fail to halt progression. Advanced diagnostics like elastography and biomarkers enable early noninvasive detection and monitoring. Novel antifibrotics and anti-inflammatories show promise targeting molecular pathways underlying fibrosis. Precision medicine facilitates personalized therapies based on genetic profiles and biomarker signatures. Regenerative approaches using stem cells and tissue engineering aim to restore liver structure and function. Transplantation advancements expand donor pools and improve outcomes. Emerging technologies like AI analytics, wearables, and telemedicine optimize clinical decision-making and accessibility. However, challenges remain regarding biomarkers' inconsistent accuracy, animal models' limitations, and translating research into practice.
Conclusion: Recent revolutionary innovations hold immense potential for unraveling the enigma of cirrhosis and transforming patient care through enhanced diagnostics, molecularly targeted treatments, regenerative strategies, and leveraging cutting-edge technologies. But continued research and multidisciplinary collaboration are vital to overcome existing barriers and realize precision, personalized cirrhosis therapies.
Peningkatan kepedulian lingkungan pesisir melalui kegiatan transplantasi karang di masyarakat pesisir Arfai Manokwari
Authors: Loinenak Frida , Kolibongso Duaitd , Sembel Luky , Manuhutu Jafry , Suhaemi  , Wattimury Dougklas , Ayhuan Hendrik
Published: February 2025

ABSTRACT 
The presence of coral reefs in coastal regions serves crucial ecological and economic functions, providing significant benefits for biodiversity and local communities reliant on these ecosystems for their livelihoods. Despite their importance, coral reefs face numerous threats stemming from both anthropogenic and natural activities. One viable restoration strategy to protect coral reef ecosystems in coastal areas is coral transplantation. This community service initiative aims to enhance understanding and awareness of the critical role of coral reef ecosystems while promoting their sustainability among the coastal communities of Arfai. The outreach program included two primary topics: coral reefs and the technique of coral transplantation. The session, lasting approximately 1.5 hours, featured a question-and-answer format to facilitate discussion and idea exchange. A demonstration of coral transplantation was conducted for residents of RT 001, utilizing the spider web method. Participants actively engaged in the transplantation process by tying seedlings and placing transplant racks in the waters surrounding Raimuti Arfai Island.
Keywords: Arfai Coastal Communities; Coral Transplantation; Environmental Concern
 
ABSTRAK 
Keberadaan terumbu karang pada wilayah pesisir memiliki fungsi dan manfaat penting secara ekologi dan  ekonomis bagi kehidupan biota dan bagi masyarakat pesisir dalam memenuhi kebutuhan hidup. Disamping potensi yang dimiliki, terumbu karang juga selalu mengalami ancaman dari berbagai aktivitas yang bersifat merusak baik akibat aktivitas antropogenik maupun alam. Salah satu upaya restorasi yang dapat dilakukan untuk menyelamatkan kehidupan terumbu karang di wilayah pesisir yaitu melalui tranplantasi karang. Tujuan kegiatan pengabdian ini adalah meningkatkan pemahaman dan kepedulian tentang pentingnya ekosistem terumbu karang dan turut menjaga kelestarian ekosistem terumbu karang kepada masyarakat pesisir Arfai. Dalam kegiatan penyuluhan terdapat 2 materi yang disampaikan yaitu tentang terumbu karang dan transplantasi karang. Kegiatan penyuluhan berlangsung selama kurang lebih 1,5 jam, dilakukan diskusi berupa tanya jawab atau saling bertukar pemikiran. Demonstrasi kegiatan transplantasi karang secara langsung kepada warga RT 001 tentang teknik transplantasi karang menggunakan metode jaring laba-laba (spider web). Warga turut dilibatkan dalam melakukan kegiatan transplantasi seperti pengikatan bibit, dan penempatan rak tranplantasi di perairan Pulau Raimuti Arfai. 
Kata Kunci: Kepedulian Lingkungan; Masyarakat Pesisir Arfai; Transplantasi Karang
Pelatihan dan penerapan teknologi pembuatan pakan nabati fermentasi pada kelompok pembudidaya ikan
Authors: Indriani Yeni , Manganang Yessi Ayu Putri
Published: February 2025

ABSTRACT 
Kampung Kuma, Tabukan Tengah sub-district, has great potential in the fisheries sector, but faces challenges in the form of high fish feed costs which reach 60-70% of total production costs. This community service activity aims to increase the productivity of farmer groups through training in fermented vegetable feed making technology. Activity methods include needs identification, counseling, practical training, and monitoring and evaluation. The training taught participants how to utilize local raw materials, such as Lemna minor, using fermentation technology to increase the nutritional value and digestibility of feed. The results showed an increase in the knowledge and skills of participants, who are now able to produce fermented feed independently. In addition, the training successfully motivated participants to apply fermentation technology sustainably, reduce dependence on commercial feed, and create efficiency in fish farming. This activity is expected to be an economical and sustainable solution to support the sustainability of fish farming businesses in Kampung Kuma. 
Keywords: Feed; Fermentation; Lemna minor; Nutritional value; Vegetable;
 
ABSTRAK 
Kampung Kuma, Kecamatan Tabukan Tengah, memiliki potensi besar dalam sektor perikanan, namun menghadapi tantangan berupa tingginya biaya pakan ikan yang mencapai 60-70% dari total biaya produksi. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan produktivitas kelompok pembudidaya melalui pelatihan teknologi pembuatan pakan nabati fermentasi. Metode kegiatan meliputi identifikasi kebutuhan, penyuluhan, pelatihan praktis, serta monitoring dan evaluasi. Pelatihan ini mengajarkan peserta cara memanfaatkan bahan baku lokal, seperti lemna minor, menggunakan teknologi fermentasi untuk meningkatkan nilai gizi dan kecernaan pakan. Hasil kegiatan menunjukkan peningkatan pengetahuan dan keterampilan peserta, yang kini mampu memproduksi pakan fermentasi secara mandiri. Selain itu, pelatihan ini berhasil memotivasi peserta untuk menerapkan teknologi fermentasi secara berkelanjutan, mengurangi ketergantungan pada pakan komersial, dan menciptakan efisiensi dalam budidaya ikan. Kegiatan ini diharapkan menjadi solusi yang ekonomis dan berkelanjutan untuk mendukung keberlanjutan usaha budidaya ikan di Kampung Kuma.
Kata kunci: Fermentasi; Lemna minor; Nabati; Nilai gizi; Pakan
Intrafamilial phenotypic variability of the Wilson–Konovalov disease in pediatric patients
Authors: Komarova Alina D. , Vorobyeva Nadezhda L. , Dzhurtubaeva Dzhanet R. , Potapov Aleksandr S. , Savostyanov Kirill V.
Published: February 2025

Introduction. The Wilson–Konovalov disease (WKD) is a rare genetic disorder characterized by polymorphism of clinical manifestations and
a progressive course with the development of irreversible and life-threatening conditions. The study of WKD phenotypes is complicated by the number of potential factors that play a role in its formation, their possible combination.
To identify the significance of these factors in the formation of clinical heterogeneity of the disease, it is advisable to conduct an analysis
in siblings who not only have the same genotype, but are also under the influence of similar environmental factors.
Objective. To evaluate the features of intrafamilial clinical polymorphism of WKD in childhood siblings and determine the range of factors influencing the course of the disease.
Materials and methods. In a retrospective study, we analyzed the health data of twenty two sibs from 11 families: 1 pair of monozygotic twins and 10 pairs of full sibs with a diagnosis of WKD established on the basis of a molecular genetic study or the diagnostic algorithm “Leipzig, 2001”.
Results. The same phenotype was observed in 8 out of 11 families: in 7 families H2/H2, in 1 family-H2+N. A different phenotype was observed in 3 families: in one — with the development of fulminant hepatitis in one of the siblings, in the other two — with the presence of neurological changes in the older sibling (H2+N/H2). In the groups of patients with neurologic changes, the values of the mean age of onset and diagnosis of WKD were significantly higher than in the group of children without these manifestations. The mean ceruloplasmin level was 14.2 ± 10.2 mg/dL
in older children and 12.8 ± 5.7 mg/dL in younger children, while the median 24-hour urine copper levels were 223.6 [35.8; 1301] μg/dL and 45.2 [5.8; 414] μg/dL, respectively. Patients with at least one “severe” mutation in the genotype had lower values of ceruloplasmin (p = 0.013) and high copper in daily urine (p = 0.02) compared to patients with two “mild” mutations in the genotype.
Conclusion. The phenotypic variability of WKD in sibs is formed mainly by the accession of neurologic changes and acute liver failure developed as a result of late diagnosis or environmental factors. The ATP7B gene genotype and some epigenetic modifications may also determine the clinical picture, but further studies are required to assess their contribution.
Enhancing Academic Excellence through Autonomy: A Data-Driven Analysis of NIRF Rankings in South Indian Higher Educational Institutions
Authors: Sumanth Reddy Shiva , Kumar B Anil , S Jahnavi , D R Manjunath , N Girish , C Nandini
Published: February 2025

Published as part of the research "Impact on NIRF Rankings", this study examines how colleges in Andhra Pradesh, Tamil Nadu, Kerala, and Telangana are performing regarding their autonomous status under the National Institutional Ranking Framework (NIRF). Using a detailed dataset from 2016–2023, the study employs advanced statistical techniques, including descriptive statistics, paired t-tests, Wilcoxonsigned-rank tests, and multiple regression models to uncover differences in rankings of NIRF before and after autonomy.Time series analysis with trend lines and moving averages can identify significant trends or rank changes across the years. Using machine learning models, they predict the rankings in the future and determine which factors have been most influential for improving ranking based on some of the commonly used machine learnings like Random Forest or Support Vector Machines (SVM). Statistical data analysis revealed a direct co-variation witnessed in autonomous status with an uplifted NIRF ranking (Teaching, Learning & Resources -TLR and Research and Professional Practice —RPC).The study also indicates that Autonomous colleges could perform better in NIRF rankings as they can have a more excellent hold on innovative initiatives, academic optimization, and higher-performance research outputs. Collectively, these insights are helpful to researchers in educational data mining and higher education management as they might inform policymakers or institutional leaders interested in using autonomy to enhance academic quality. This is an exploratory study, and future research should adopt a longitudinal perspective and expand it to investigate other performance indicators, such as student satisfaction or employability. The study highlights the importance of autonomy in improving India's ranking in higher education through a strong methodological framework and sophisticated data analysis techniques adopted by this research work.
Brand Associations of Cross Training Centers and Repurchase Intentions and Word-of-Mouth
Authors: Gama Marco Vinicius Acioli da , Miranda Yves , Pedroso Carlos Augusto Mulatinho de Queiroz
Published: February 2025

Introduction: Brazil ranks second in the number of CrossFit® boxes, the leading cross-training brand, behind only the United States. As a result, there is growing interest among managers of these brands in developing strong associations with the organization's image. Moreover, consumer loyalty is a fundamental condition for the development of any organization, and one of the ways to analyze it is through behavioral intentions. Objective: To identify the brand associations and behavioral intentions present in the minds of customers of cross-training centers. Methods: The study focused on participants from cross-training boxes in the metropolitan area of Recife-PE. It employed a descriptive quantitative approach, and the design was considered a survey. Data collection was carried out through an adapted questionnaire, disseminated online via Google Forms. The data were tabulated in Excel 2019 software, and the analysis was performed using the Statistical Package for the Social Sciences (SPSS). Results and Discussion: The dimensions related to brand associations and behavioral intentions yielded positive results, indicating that all associations are present in the consumer's mind. The results also indicated a high rate of repurchase intentions and word-of-mouth promotion. Conclusion: The dimensions "Escape", "Coach", and "Service Delivery" were the most prominent associations in the consumer's mind, while "Logo Design" and "Physical Environment" were the dimensions with lower value. All behavioral intentions were strong, indicating a good likelihood of being carried out in the future.
La hibridación tecnológica en la Educación Física no formal
Authors: Sancio Daniel Rodrigo
Published: February 2025

El objetivo del ensayo fue reflexionar sobre las transformaciones que las tecnologías digitales han generado en la realización de ejercicio físico y en el rol del docente de Educación Física en el contexto no formal. A través de una mirada epistemológica, se explora cómo el uso de dispositivos tecnológicos, como relojes inteligentes y aplicaciones de monitoreo, redefine no sólo la actividad física sino también las interacciones entre docentes y alumnos en entornos virtuales. A partir de fragmentos de tres obras de diferentes autores, se plantea que el "útil" tecnológico no es simplemente una herramienta pasiva, sino un agente activo que modula la relación entre el cuerpo y el entorno. El texto profundiza en la hibridación entre lo presencial y lo digital, argumentando que esta fusión permite nuevas formas de acompañamiento pedagógico, que trascienden la supervisión directa del docente. Además, se destacan las oportunidades y desafíos que surgen de la virtualización del entrenamiento, así como la necesidad de que los profesionales de la educación física adquieran competencias en el uso de tecnologías digitales. Finalmente, se subraya que este cambio no es meramente técnico, sino que implica una transformación epistemológica y profesional que redefine los límites del campo laboral, las interacciones sociales y la motricidad en la Educación Física no formal del siglo XXI.
Análisis de la velocidad en estudiantes de secundaria en el área de Educación Física
Authors: Durán Ángel Luis
Published: February 2025

El presente estudio se planteó el objetivo de analizar los tiempos de velocidad de estudiantes de secundaria para establecer categorías de desempeño. La población considerada fue de 113 estudiantes de segundo de secundaria del centro educativo Carlos Díaz, ubicado en el distrito 08-09 de la República Dominicana, se escogió una muestra de forma aleatoria de 56 estudiantes: el 59% de un grupo masculino y el 41% de un grupo femenino en edades entre 12 a 14 años. La técnica utilizada fue la observación directa, y el instrumento empleado fue el test 10 x 5, utilizado en este trabajo para medir la velocidad en la muestra de estudio. Este test resultó ser muy confiable según el coeficiente de Pearson entre las fases pre-test y postest (r=0,991), resultados obtenidos con el SPSS versión 23. Los principales hallazgos revelaron que la muestra obtuvo un tiempo mínimo de 16,16 segundos, un tiempo máximo de 24,14 segundos y una media de 19,57. Por otro lado, según los percentiles se evidenció que el 25% completaron el test en un tiempo menor o igual a 18,50 segundos, siendo esta la categoría de tiempo más rápida. En cambio, el 75% completó la prueba en un tiempo menor o igual a los 20.84 segundos, siendo esta la categoría lenta. Entre las principales conclusiones se expone que el test resultó muy efectivo para determinar la velocidad de los estudiantes y que la Educación Física puede servir como espacio de mejora de dicha capacidad.
Diversificação das estratégias de metodologias ativas no ensino de Terapia Ocupacional: estudo observacional da prática docente
Authors: Rocha Manuela Lima Carvalho da , Rodrigues Yasmin Fernanda Florencio , Nascimento Cibele Braga Ferreira , Monteiro Magda Regiane Lima de Carvalho
Published: February 2025

Resumo:
Este artigo analisa a prática docente de ensino pautadas na diversificação do uso das metodologias ativas no processo de ensino e aprendizagem do curso de graduação em Terapia Ocupacional da Universidade Federal do Pará. O desenho do estudo observacional de caráter transversal da análise da prática docente ocorreu no primeiro semestre de 2023 com a turma do 5º período do curso e foram descritas a aplicação de metodologias no período de duas semanas nos componentes curriculares referente a Saúde do Adulto e Fundamentos e recursos em Terapia Ocupacional no Adulto. As atividades tiveram como proposta a construção do conhecimento a partir da utilização de metodologias ativas de ensino participativas e problematizadoras, favorecendo a aquisição de conteúdos e a autonomia do aluno no seu processo de formação acadêmica e profissional. Observou-se que as vivências oportunizadas por meio da diversificação de metodologias proporcionaram um aprendizado dinâmico e aquisição de habilidades pelos discentes.
Palavras-chave: Ensino. Aprendizagem. Terapia ocupacional.
Mulheres, home office e pandemia em retrospectiva: relatos de servidoras de uma instituição de ensino superior no interior da Amazônia
Authors:   , Valente Priscila Fonseca
Published: February 2025

Este estudo se concentra especialmente na experiência do trabalho remoto (home office) adotado por mulheres do Centro de Estudos Superiores de Parintins da Universidade do Estado do Amazonas, ação adotada como medida para conter a propagação da Covid-19. Especificamente, objetivou-se compreender como as experiências de trabalho em home office durante a pandemia da COVID-19 impactaram a vida profissional e pessoal das servidoras técnico administrativas do CESP/UEA. De modo específico, pretendeu-se: (i) identificar estereótipos e estigmas a respeito de gênero, sob a perspectiva das servidoras do CESP/UEA; (ii) descrever a experiência das participantes na vivência de home office ao longo da pandemia; (iii) compreender a relação entre vida pessoal e profissional das servidoras do CESP/UEA durante a pandemia da Covid-19. A pesquisa adotou a abordagem qualitativa. Para a coleta de dados utilizou-se a aplicação de entrevistas com roteiro semi-estruturado, utilizando também a técnica de análise e interpretação de dados a Análise de Conteúdo Categorial. No qual evidenciou-se a partir dos resultados, que a experiência de trabalho remoto durante a pandemia foi multifacetada, com servidoras enfrentando uma série de desafios, tais como: Desafios relacionados a estereótipos de gênero: Carga desigual de trabalho, pressões sociais. Experiência do home office: Desafios em estabelecer limites, pressão por resultados, falta de valorização do trabalho remoto. Impactos na relação entre vida pessoal e profissional: Sobrecarga e estresse, impacto na saúde mental. Esses fatores influenciaram diretamente no desenvolvimento de suas atividades profissionais, reforçando a problemática da desigualdade de gênero no mercado de trabalho enraizada em nossa sociedade. Palavras-chave: palavras-chave: mulheres; home office; trabalho remoto; pandemia da covid-19.
Curcumin-Based Polyurethane Coatings: A Novel Bioactive Solution
Authors:   Amruteshwar Arts, Commerce and Science College, Vinzar, Tal. Velhe, Dist Pune (MS) India, Kamble Rahul D , Hese Shrikant V ,   D.D.Bhoyar College of Arts And Science Mouda Dist. Nagpur (MS) India, Gaikwad Milind V ,   DY Patil Arts, Commerce and Science College Pimpri, Pune (MS) India
Published: February 2025

This paper reports the preparation of polyurethane (PU) coatings using aromatic diisocyanates (methylene diisocyanate (MDI), toluene diisocyanate
(TDI), and MDI/TDI mixture) with natural diols like curcumin, employing an organotin catalyst (DBTDL). The PU mixtures were applied using a brush
on steel, aluminum panels, and various polymers, and their coating characteristics were evaluated, including gloss, scratch resistance, impact resistance,
pencil hardness, and chemical resistance. Increasing the molar ratio of natural diols enhanced coating flexibility but reduced hardness. Additionally, the
PU coatings were analysed for thermal stability using thermo gravimetric analysis, demonstrating the successful production of eco-friendly, bio based PUs
through an economically viable process.
Development of Environment Sustainability by Conjugated Ligands in Bio Orthogonal Chemistry
Authors:   Department of Chemical Engineering, Haldia Institute of Technology (Autonomy), Haldia-722657, West Bengal, India, Mukhopadhyay Taanisha
Published: February 2025

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions
towards endogenous functional groups.Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in
biological environments without side reactions towards endogenous functional groups. Bioorthogonal chemistry allows organic synthesis ordinarily performed
in a laboratory to be performed in living organisms and cells. Thus it helps in increasing the sustainability of the environment. Bioorthogonal chemistry is a set
of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.
Studies of XPS Technique and Application in Thickness Measurement of Ultra-Thin Film
Authors:   Wintech-Nano (Nanjing) Pte Ltd Floor 1, Building B, No 6, Mingyuan Road, Yuhuatai District Nanjing, China,Wintech Nano-Technology Services Pte Ltd,The Alpha #03-26, 10 Science Park Rd, Singapore Science Park II, Singapore, Hua Younan
Published: February 2025

X-Ray Photoelectron Spectroscopy (XPS) analysis technique has been widely applied in semiconductor manufacturing and failure analysis. We used it for
defects analysis and thin film characterization in wafer fabrication and for XPS valence state analysis of copper materials. XPS technique is also applied
jointly with TOF-SIMS technique. In wafer fab, semiconductor & LED manufacturing, it is very challenging to measure the thickness of an ultra-thin film
at nano meter range. In general, TEM is widely used for ultra-thin film physical measurement but usually its lateral dimension is limited. In this paper
we will study X-Ray Photoelectron Spectroscopy analysis technique which employ a new analysis method by using angle resolved analysis technique.
Furthermore, we have applied the new method in analysis of SiON film. It is achieved to measure an ultra-thin film at about 1.4nm. This method can be
used for SiO2
thickness measurement, self-assembled thiol monolayer on Au and thickness of HfO2 on silicon substrate.
Experimental Investigation and Analysis of Hybrid Laminates
Authors: Mr. Ashish Apate  , Dr. Sanjeev Kumar  , Dr. Nitin H. Ambhore
Published: February 2025

Hybrid composites have gained significant attention from researchers due to their potential as reinforcement materials for composites. This is primarily because of the numerous advantages they offer, including low density, low cost, renewability, biodegradability, and environmental safety, along with mechanical properties that are comparable to those of synthetic fiber composites. In this study, hybrid composites made from natural fibers and glass fibers were fabricated using epoxy resin and a combination of the hand lay-up method and the cold press method. Specimens were cut from the fabricated laminate according to ASTM standards for various tests, including tensile, flexural, and impact tests. The woven fiberglass hybrid composites demonstrated a notable improvement in tensile strength. Consequently, these high-performance hybrid composites display enhanced mechanical characteristics and have wide-ranging engineering applications in industries such as transportation, aeronautics, naval, and automotive.
Analytical and Practical Comparison of Various Test on Pile
Authors: Gaurav Hande  , Bharati Shete  , Ashish Bijwe  , Sneha M. Jadhal
Published: February 2025

High Strain Dynamic Pile Test (HSDT) is increasingly being used for pile load testing. HSDT offers a considerable savings of time, cost and requires very little space compared to the conventional static test. However, it is yet mandatory to compare HSDT tests with static load tests (SLT) to confirm the validity of HSDT as the results are generally site specific. This study presents comparison of static pile load test (SLT) vs HSDT and attempt is made to close the gap between theoretical and practical justification for replacing SLT with HSDT by identifying the problems while conducting and comparing both the tests. Also, a resourceful methodology is produced to conduct efficient comparison of SLT and HSDT which can be used at any site.
Handwriting Recognition Implementation: A Machine Learning Approach
Authors: Dr. A. Shaji George
Published: February 2025

Handwritten text recognition, also referred to as handwritten character recognition, is a field of study that combines model recognition, computer vision, and artificial intelligence. In order to translate handwritten letters into relevant text and computer commands in real time, handwriting recognition systems use pattern matching. The properties of photographs and touch-screen devices can be acquired, detected, and converted into a machine-readable form by an algorithm that recognizes handwriting. An ensemble of bagged classification trees is one way to accomplish this. A bagged classification tree is an ensemble learning technique that helps to increase the efficiency and accuracy of machine learning algorithms by lowering the variance of a prediction model and addressing bias-variance trade-offs. The standard Kaggle digits dataset from (0-9) was utilised in this study to identify handwritten digits using a bagged classification method. And with an accuracy level of 0.8371, we finally came to a conclusion about the importance of the bagged classification strategy.
Professional burnout in doctors in medical institutions in Republic of Ghana
Authors: Akuoko Ebenezer , Alenitskaia Marina V.
Published: February 2025

Introduction. Professional burnout among medical workers is known to be associated with increased workloads, for example, when medical institutions are understaffed with medical personnel, overtime work, and stressful situations. These factors also apply to medical staff in Ghanaian health care institutions. However, there is a lack of research examining how different professionals in healthcare settings in Ghana respond to burnout. There is a need to plan and develop interventions aimed at preventing burnout among healthcare workers in Ghana.
Materials and methods. Survey questions for the conduct of this study included the Maslach Burnout Inventory (MBI) survey, which was used to assess the level of emotional burnout. At the same time, we added special questions to the questionnaire, which assessed the intensity of work of representatives of various specialties of medical institutions in Ghana. We conducted sociological survey to collect data about risk factors for diseases, which were present from the period 2018 to 2022, among workers of medical facilities in Ghana. One thousand eighty three workers participated. In this study, doctors were divided into professional groups, 4 in total. These groups were represented by the following specialties: surgery, therapy, laboratory diagnostics, representatives of the administrative level. We analyzed the data by the use of SPSS, and presented the results in descriptive statistics and correlation analysis.
Results. The study found differences in the levels of professional burnout, as well as differences in the intensity of work functions among doctors in various specialties. Thus, surgeons were characterized by the highest intensity of work (p <0.001). The therapeutic group, on the other hand, was characterized by an average level. Specialists of laboratory and diagnostic units and administrative level were distinguished by work of the least intensity. However, signs of burnout are common among surgeons, therapists, laboratory technicians, and administrators in Ghanaian hospitals.
Limitations. The lack of regulations governing the conduct and assessment of working conditions, a system for recording and investigating cases of occupational diseases, and special equipment for measuring working conditions in Ghana served as limitations to our scientific research.
Conclusion. Taking into account the results of our study to establish the facts of the development of professional burnout among medical workers in medical institutions in Ghana, it is necessary to apply preventive measures at the level of the Government of Ghana (development of a legal framework, regulatory documents, accounting and reporting forms for registration, measuring instruments and methods for their use for assessing working conditions, preventive programs).
Evaluation of apoptosis gene expression and morphological changes in kidney tissue under acrylamide exposure and prophylactic drug correction
Authors: Repina Elvira F. , Karimov Denis O. , Baygildin Samat S. , Yakupova Tatyana G. , Khusnutdinova Nadezhda Yu. , Shaikhlislamova Elmira R. , Bakirov Akhat B. , Gimadieva Alfiya R. , Smolyankin Denis A.
Published: February 2025

Introduction. Acrylamide is a well-known toxicant, contact with which occurs both in industrial and domestic conditions. It has been found to have nephrotoxic properties.
The purpose of the work is to evaluate the expression of the Casp7, Chek1 genes and changes in the structure of the kidney tissue in rats under long-term exposure to acrylamide and preventive correction.
Materials and methods. The experiment used sixty white outbred male rats. Acrylamide was administered intragastrically at a dose of 5 mg/kg body weight for 90 days. Correction of possible violations was carried out 1 hour before the administration of the toxicant with complex compounds of hydroxymethyluracil. Gene expression was studied using real-time PCR. SPSS Statistics 21.0 software (IBM, USA) was used for statistical data analysis. Morphological studies of the structure of rat kidneys were carried out using standard methods.
Results. Studies have shown that exposure to acrylamide for 3 months at a dose of 5 mg/kg body weight causes structural changes in the kidney tissue in rats. With long-term exposure to acrylamide, there is a tendency to increase the expression of the Chek1 and Casp7 genes, which may indicate cell damage and activation of repair and apoptosis processes in them. The combination of hydroxymethyluracil with acetylcysteine had the greatest protective effect on the structure of the kidneys and the expression of the Casp7 gene.
Limitations are that morphological changes in kidney tissue during long-term exposure to acrylamide were correlated with the expression of only two apoptotic genes. For a more complete understanding of the pathogenetic changes during the damaging effect of acrylamide on the kidneys, it is necessary to conduct a multivariate analysis taking into account other toxicological and genetic indicators.
Conclusion. Acrylamide, when ingested for a long time at a dose of 5 mg/kg body weight, has a nephrotoxic effect, which is confirmed by data from morphological studies and a tendency to increase the expression of the main apoptosis genes in kidney tissue. The best protective effect according to the studied parameters was observed with the prophylactic administration of a complex compound of hydroxymethyluracil with acetylcysteine.
Public Health in Africa: driving health and well-being
Authors: Joseph-Aluko Olivia
Published: February 2025

This paper delves into strategies for enhancing public health and well-being in Sub-Saharan Africa, specifically focusing on the health challenges prevalent in West African countries, notably Nigeria and Ghana. The study is firmly aligned with Sustainable Development Goal (SDG) 3, a goal that resonates with our region’s health and well-being concerns, thereby ensuring the relevance and significance of our research.

Purpose: This study analyses the current health challenges in West Africa, specifically in Nigeria and Ghana, and proposes strategies for improving public health and well-being in the region in alignment with SDG 3.

Design/Methodology/Approach: This study utilises a secondary qualitative research method involving a comprehensive review of existing literature, reports and policy documents related to health challenges in Sub-Saharan Africa. Data analysis includes thematic analysis to identify key themes and patterns in the selected data.

Findings: The findings of this study highlight the significant health challenges faced by West African countries, including high rates of infectious diseases, maternal and child mortality and limited access to healthcare services. The study also identifies strategies for improving public health and well-being in the region, including enhancing healthcare infrastructure, increasing access to essential medicines and vaccines, and promoting community engagement in healthcare decision-making.

Originality/Value: This study contributes to the existing literature by offering practical insights into the health challenges faced by West African countries and proposing evidence-based strategies for enhancing public health and wellbeing in the region. The findings have the potential to significantly influence policy-making and healthcare interventions, paving the way for the achievement of SDG 3 in Sub-Saharan Africa.
Practical Implications: The disparity between the wealthy and the impoverished in West Africa remains considerable, with factors such as education, gender and poverty significantly contributing to health inequalities.

Keywords: Public Health; Well-Being; Sub-Saharan Africa; Sustainable Development Goals; SDG 3; West Africa; Nigeria; Ghana.

Citation: Joseph-Aluko, O. (2024): Public Health in Africa: Driving Health and Well-Being. International Journal of Food, Nutrition and Public Health (IJFNPH), Vol. 14, No. 1-2, pp.15-29.
Influence of Water Temperature on Fish Reproduction in Bangladesh
Authors: Rahman Amina
Published: February 2025

Purpose: The aim of the study was to analyze the influence of water temperature on fish reproduction in Bangladesh.
Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
Findings: The study found that water temperature significantly impacts fish reproduction in Bangladesh, with optimal breeding occurring at 25–30°C. Higher temperatures (>32°C) reduced sperm motility and hatch rates, while lower temperatures (<20°C) delayed spawning. Climate change-induced temperature shifts may disrupt fish breeding patterns, affecting aquaculture productivity. Temperature regulation and seasonal monitoring are recommended for sustainable fisheries.
Unique Contribution to Theory, Practice and Policy: Metabolic theory of ecology (MTE), thermal bottleneck hypothesis & brain-pituitary-gonad (BPG) axis theory may be used to anchor future studies on the influence of water temperature on fish reproduction in Bangladesh. Fisheries and aquaculture should select and breed fish species with higher thermal tolerance, ensuring stable reproductive success despite temperature changes. Governments must revise fisheries policies to integrate climate adaptation strategies, ensuring that breeding habitats and spawning seasons are protected from rising temperatures and extreme weather events.
PEMBUATAN PERJANJIAN KAWIN PADA KANTOR NOTARIS DI MEDAN
Authors: Ry Agus Armaini , Irwansyah Irwansyah , Hayati Winta , Lubis Diana , Rahmadani Gema
Published: February 2025

Perjanjian perkawinan adalah perjanjian yang dibuat sebelum perkawinan dilangsungkan untuk mengadakan beberapa penyimpangan dari ketentuan undang-undang yang mengatur tentang harta kekayaan perkawinan. Akibat perkawinan dilangsungkan maka perjanjian kawin seketika itu akan mengikat kedua belah pihak, isinya dapat mengenai masalah persatuan harta bawaan atau pemisahan harta kekayaan di antara suami istri yang meliputi apa yang menjadi milik suami atau isteri dan apa saja yang menjadi tanggung jawab suami dan isteri, ataupun berkaitan dengan harta bawaan. Faktor-faktor yang menyebabkan calon suami isteri membuat perjanjian kawin dalam  perkawinannya adalah adanya pergeseran nilai/fungsi dan peran dalam rumah tangga yaitu fungsi isteri saat ini tidak hanya sebagai Ibu Rumah Tangga, tetapi juga ikut mencari nafkah. Hal-hal yang dibatasi atau tidak boleh diatur dalam pembuatan perjanjian kawin adalah tidak boleh bertentangan dengan kesusilaan atau ketertiban umum.
STRATEGI PENCEGAHAN CYBERBULLYING MELALUI PEMAHAMAN UU ITE DI KALANGAN MAHASISWA
Authors: Siregar Gomgom TP , Siregar Delvira Oktaviani
Published: February 2025

Perkembangan teknologi digital telah membawa perubahan besar dalam berbagai aspek kehidupan, termasuk komunikasi di kalangan mahasiswa. Media sosial dan platform digital lainnya menjadi sarana utama dalam berinteraksi, berbagi informasi, dan mengekspresikan pendapat. Rumusan Kegiatan yaitu Bagaimana tingkat pemahaman mahasiswa terhadap UU ITE dalam kaitannya dengan cyberbullying, Strategi apa yang dapat diterapkan untuk meningkatkan kesadaran dan pencegahan cyberbullying di kalangan mahasiswa. Metode pelaksanaan kegiatan ini meliputi beberapa tahapan yang sistematis untuk memastikan efektivitas program. Tahapan tersebut adalah sebagai berikut: Sosialisasi dan PenyuluhanKegiatan ini dilakukan melalui seminar dan workshop yang melibatkan mahasiswa, dosen, dan praktisi hukum. Cyberbullying di kalangan mahasiswa merupakan masalah yang perlu mendapatkan perhatian serius. Pemahaman terhadap Undang-Undang Informasi dan Transaksi Elektronik menjadi kunci dalam mencegah terjadinya cyberbullying di lingkungan kampus. Strategi-strategi seperti peningkatan literasi digital, penguatan kebijakan kampus, kampanye kesadaran digital, dan pemberdayaan layanan pengaduan dapat menjadi langkah efektif untuk mendorong mahasiswa memahami UU ITE dan meningkatkan kesadaran akan bahaya cyberbullying.
INOVASI E-COURT DALAM PROSES PENGADILAN PERDATA: MANAJEMEN LITIGASI SECARA ELEKTRONIK
Authors: Rahmadani Gema , Novita Rini , Lubis Muhammad Ansori , AR Azhari , Faisal Muhammad
Published: February 2025

Penerapan sistem e-court dalam perkara perdata di Indonesia merupakan salah satu upaya untuk meningkatkan efisiensi, transparansi, dan aksesibilitas dalam proses peradilan. E-court memungkinkan seluruh proses litigasi, mulai dari pendaftaran perkara, pengajuan dokumen, pembayaran biaya perkara, hingga pelaksanaan sidang, dilakukan secara elektronik. Tujuan utama penelitian ini adalah untuk menganalisis penerapan e-court dalam perkara perdata di Indonesia, serta manfaat dan tantangan yang dihadapi dalam implementasinya. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi literatur, wawancara, dan observasi untuk menggali informasi dari berbagai sumber terkait, termasuk pengadilan, praktisi hukum, dan masyarakat. Hasil penelitian menunjukkan bahwa meskipun e-court membawa berbagai keuntungan, seperti mempercepat proses peradilan dan mengurangi biaya litigasi, penerapannya masih menghadapi sejumlah kendala, termasuk infrastruktur teknologi yang belum merata, keterbatasan sumber daya manusia, dan isu keamanan data. Meskipun demikian, e-court memiliki potensi untuk mewujudkan sistem peradilan yang lebih modern dan adil, asalkan tantangan-tantangan tersebut dapat diatasi dengan baik. Penelitian ini memberikan rekomendasi untuk memperkuat infrastruktur dan pelatihan bagi aparat peradilan guna mendukung penerapan e-court secara optimal.
IMPLEMENTASI PENGAWASAN TERHADAP NETRALITAS APARATUR SIPIL NEGARA DALAM PELAKSANAAN PEMILIHAN UMUM
Authors: Sintara Dani
Published: February 2025

Aparatur Sipil Negara (ASN) diharuskan berada pada posisi netral. Netral disini diartikan bahwa ASN mempunyai hak suara untuk memilih pasangan calon dalam pemilihan umum, hanya saja tidak diperbolehkan terlibat saling mendukung kepada salah satu pasangan calon termasuk pasangan incumbent. Penulisan ini menggunakan metode telaah pustaka (library research) untuk mentelaah data-data sekunder. Pengaturan peranan Bawaslu dalam melaksanakan pengawasan pemilu adalah Undang-Undang Nomor 7 Tahun 2017 tentang Pemilihan Umum, Undang-Undang Nomor 10 Tahun 2016 tentang Pemilihan Gubernur, Bupati dan Wali Kota. Tugas dan wewenang Bawaslu dalam pemilihan kepala daerah Bupati diatur dalam Pasal 101 Undang-Undang Nomor 7 Tahun 2017 tentang Pemilihan Umum. Implementasi peranan Bawaslu dalam melakukan pengawasan terhadap netralitas ASN adalah sebagai pengawas pemilu termasuk pengawasan terhadap netralitas ASN, TNI, maupun Polri. Atas dasar itu wewenang Bawaslu dalam hal menangani netralitas ASN tidak hanya dalam kontek penegakan hukum (pro justitia) tetapi juga dalam kontek melakukan pengawasan atau dengan kata lain pintu masuk wewenang Bawaslu dalam menangani netralitas ASN dapat melalui fungsi pengawasan dan dapat pula melalui fungsi penegakan hukum
ANALISIS EFEKTIVITAS MUTASI PEGAWAI NEGERI SIPIL DI KANTOR BKPSDM KOTA GUNUNGSITOLI
Authors: Larosa Zasmin Ayu Lestari , Telaumbanua Eliagus , Zega Yamolala , Waruwu Meiman Hidayat
Published: February 2025

Mutasi pegawai adalah proses pemindahan fungsi, tanggung jawab dan status kepegawaian PNS guna memenuhi kebutuhan pegawai di unit atau bagian yang membutuhkan sebagai suatu pembinaan dan pengembangan karier yang dilakukan untuk meningkatkan prestasi kerja pegawai. Tujuan penelitian ini adalah untuk menganalisis efektivitas mutasi pegawai negeri sipil di kantor Badan Kepegawaian dan Pengembangan Sumber Daya Manusia (BKPSDM) Kota Gunungsitoli. Adapun metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif dengan pendekatan kualitatif. Hasil penelitian menunjukkan bahwa proses mutasi di BKPSDM secara umum belum sepenuhnya efektif karena terdapat beberapa hambatan yang mempengaruhi kelancaran proses mutasi, seperti ketidakcocokan kompetensi dengan jabatan baru, resistensi terhadap perubahan, pengaruh politik dan nepotisme.
ANALISIS LAYANAN USAHA TAYLOR DALAM MENINGKATKAN PENDAPATAN KARYAWAN DI WILAYAH KECAMATAN KOTA GUNUNGSITOLI
Authors: Waruwu Yeniman , Telaumbanua Eliagus , Gea Jeliswan Berkat Iman Jaya , Lase Delipiter
Published: February 2025

Penelitian ini bertujuan untuk menganalisis layanan usaha Taylor dalam meningkatkan pendapatan karyawan di Kecamatan Kota Gunungsitoli. Dengan menggunakan pendekatan deskriptif kualitatif, data dikumpulkan melalui wawancara, observasi, dan dokumentasi. Penelitian ini menyoroti empat aspek utama: jenis layanan usaha Taylor, kualitas layanan, variasi tarif, dan peran Dinas Perindustrian dan Koperasi UKM. Hasil penelitian menunjukkan bahwa usaha Taylor menawarkan layanan pembuatan pakaian khusus, perbaikan pakaian, dan penyewaan pakaian, yang mendukung diversifikasi pendapatan. Kualitas layanan, seperti ketepatan waktu, kerapihan jahitan, dan keramahan, memainkan peran penting dalam meningkatkan kepuasan pelanggan dan jumlah pesanan. Variasi tarif berdasarkan kompleksitas pakaian memberikan fleksibilitas dalam menjangkau berbagai segmen pelanggan, meskipun memerlukan keseimbangan untuk menjaga stabilitas pendapatan. Peran pemerintah melalui pelatihan teknis dan bantuan alat produksi memberikan dampak positif, tetapi cakupannya masih terbatas. Penelitian ini menyimpulkan bahwa peningkatan kualitas layanan, penyesuaian tarif yang kompetitif, dan dukungan pemerintah yang lebih berkelanjutan menjadi kunci utama dalam meningkatkan pendapatan karyawan dan keberlanjutan usaha Taylor. Studi ini relevan dalam konteks lokal dan memberikan panduan strategis bagi pelaku usaha kecil dan menengah untuk menghadapi tantangan persaingan.
PENGARUH TRANSISI KEPEMIMPINAN TERHADAP TINGKAT KEPERCAYAAN ANGGOTA PADA CREDIT UNION KARYA KASIH SEJAHTERA GUNUNGSITOLI
Authors: Lase Nolinia , Telaumbanua Eliagus , Baene Eduar , Bate’e Maria Magdalena
Published: February 2025

Kepemimpinan adalah sebuah alat/sarana atau suatu proses dalam organisasi untuk membujuk orang lain agar bersedia melakukan sesuatu secara sukarela/sukacita dalam mencapai sasaran organisasi. Kepemimpinan terkadang dipahami sebagai sekedar kekuasaan untuk menggerakkan dan mempengaruhi orang lain. Adapun masalah yang menjadi dasar dari judul penelitian penulis adalah: “Apakah ada pengaruh transisi kepemimpinan terhadap tingkat kepercayaan anggota di Credit Union Karya Kasih Sejahtera Gunungsitoli?” dan Seberapa besar pengaruh transisi kepemimpinan terhadap tingkat kepercayaan anggota di Credit Union Karya Kasih Sejahtera Gunungsitoli?. Jenis penelitian yang digunakan dalam penelitian ini adalah jenis penelitian Kuantitatif. Dimana penulis akan menganalisa serta menarik Kesimpulan penelitian bersifat kuantitatif/statistik. Yang menjadi populasi dalam penelitian ini adalah anggota Credit Union Karya Kasih Sejahtera Gunungsitoli dengan jumlah populasi adalah 1.430 orang. Peneliti mengambil menjadi sampel penelitian, yaitu Credit Union Karya Kasih Sejahtera Gunungsitoli berjumlah 100 orang. Teknik pengumpulan data penelitian ini, menggunakan dua macam , yaitu melalui obeservasi dan kuesioner. Hasil penelitian menunjukan bahwa: (1) Transisi kepemimpinan berpengaruh positif terhadap tingkat kepercayaan anggota di Credit Union Karya Kasih Sejahtera Gunungsitoli, berdasarkan perhitungan koefisien korelasi sebesar 0,914 sehingga rhitung > rtabel (0,914>0,196).  (2) Dari hasil angket yang diolah disimpulkan bahwa Varibel X (transisi kepemimpinan) berpengaruh sebesar 83,5% terhadap variable Y (tingkat kepercayaan anggota), dan sisanya 16,5% tidak dapat dijelaskan atau dipengaruhi oleh faktor lain yang tidak termasuk dalam pembahasan penelitian ini.