bluuebunny/crossref_metadata_2025 huggingface dataset:
Postoperative Ovarian Vein Thrombosis and Treatment with Direct Oral Anticoagulant
Authors: Shukr Ghadear , Gonte Madeleine R. , Webber Victoria E. , Abood Joelle A. , Arsanious Samah , Eisenstein* David
Published: May 2023

Postoperative ovarian vein thrombosis (OVT) is a rare complication following hysterectomy. Due to its ambiguous presentation, most frequently presenting as a fever with no known source and lower quadrant abdominal pain, OVTs are commonly diagnosed incidentally on computed tomography as a low-attenuation thrombus in place of the ovarian vein. The cornerstones of OVT treatment include anticoagulation and antibiotic therapy; however, there are no current guidelines to inform provider decision-making regarding specific anticoagulant agents, dosing, or length of therapy. We present a patient with a history of deep-vein thrombosis, who presented to the emergency department with OVT following a laparoscopic hysterectomy. She was treated with apixaban, a direct oral anticoagulant (DOAC), and experienced repeated episodes of vaginal bleeding and hematoma expansion. We present this case to instill a high index of suspicion for OVT after laparoscopic hysterectomy, and to discuss the role of DOACs in patients with thromboembolic disease and concurrent bleeding.
Scope and Suction: Hysteroscopic-guided Suction Evacuation of Cesarean Scar Pregnancy – A Safe and Efficacious Treatment for Selected Patients
Authors: Hameed* Mohamed Siraj Shahul , Wright Ann , Chern Bernard Su Min
Published: May 2023

Objectives:

This study aimed to evaluate hysteroscopic-guided suction evacuation for the treatment of cesarean scar pregnancy (CSP).

Materials and Methods:

This was a retrospective analysis of CSP over 2 years. This study was conducted at KK Women’s and Children’s Hospital (KKH), Singapore, thirty-seven patients with a CSP. Hysteroscopic-guided suction evacuation to treat CSP used alone or in combination with laparoscopy depending on residual myometrial thickness (RMT) and future fertility requirements.

Results:

The majority of women (29) were diagnosed under 9-week gestation. Just over a third (13) had an RMT of more than 3 mm. Women with an RMT <3 mm had added laparoscopy. In total, 22 women had hysteroscopic-guided suction evacuation with 9 having it performed under laparoscopic guidance because the RMT was under 3 mm. The remaining patients underwent either laparoscopic repair (5 cases) or vaginal repair (1 case) done under laparoscopic guidance.

Conclusion:

Hysteroscopic-guided suction evacuation of CSP has the potential to become part of the routine management for uncomplicated cases of CSP in women with an RMT of greater than 3 mm who do not wish for future pregnancy. Its use, in combination with other minimally invasive techniques, can be extended to more complex cases where the RMT is <3 mm and future fertility is desired.
Application of big data in ophthalmology
Authors: Soh Zhi Da , Cheng Ching-Yu
Published: May 2023

The advents of information technologies have led to the creation of ever-larger datasets. Also known asbig data, these large datasets are characterized by its volume, variety, velocity, veracity, and value. More importantly, big data has the potential to expand traditional research capabilities, inform clinical practice based on real-world data, and improve the health system and service delivery. This review first identified the different sources of big data in ophthalmology, including electronic medical records, data registries, research consortia, administrative databases, and biobanks. Then, we provided an in-depth look at how big data analytics have been applied in ophthalmology for disease surveillance, and evaluation on disease associations, detection, management, and prognostication. Finally, we discussed the challenges involved in big data analytics, such as data suitability and quality, data security, and analytical methodologies.
An approach to financial information analysis by the Brazilian Federal Police
Authors: Filho Renato Kettner , Macedo Douglas D. J. de
Published: May 2023

INTRODUCTION: One of the tasks performed by the Federal Police is the verification and cross-referencing of data contained in Financial Intelligence Reports (FIRs) produced and forwarded by the Financial Activities Control Council (COAF) - an activity in which, among the police involved, the absence of a standard system of execution.OBJECTIVES: The present work aims to present a study on the form currently in use within the scope of the Federal Police Station regarding the analysis of FIRs from the COAF, then presenting a methodology suggestion, aiming to speed up the process. Regarding open sources, the objective is to carry out a survey of possible complementary repositories not yet used and to expose ways of implementing queries.METHODS: Pointing out the workflow currently used (displaying it in graphic form) as well as identifying the data sources consulted (open sources and closed sources) during the process,CONCLUSION: understanding how the FIR analysis system is currently carried out, identifying possible aspects for improvement, and suggesting a methodology to be used, indicating for this the use of files in a specific format (.CSV), exclusion of queries in similar repositories (System “A”) and, mainly, the automation of part of the procedure (with the use of the RIBOT prototype software).
Marcas y propósito: Análisis de las estrategias digitales en Twitter de las marcas más reputadas en España
Authors: Fernández Gómez Jorge David , Gordillo-Rodríguez María-Teresa , Pacheco Barriga Laura , Fernández Blanco Elena
Published: May 2023

Introducción: El siglo XXI está caracterizado por el avance tecnológico que ha experimentado la sociedad junto a los cambios sociales, económicos y medioambientales que conforman los desafiantes retos actuales. Estos han provocado que multitud de organizaciones se conviertan en agentes activos, despertando su interés por definir propósitos con impacto para la sociedad que necesita que las empresas tomen conciencia y se posicionen, desde un enfoque más humanista, ante cuestiones alarmantes. Uno de los escenarios en el que las organizaciones pueden desarrollar estrategias de comunicación que enriquezcan las relaciones con sus públicos y les permita defender sus propósitos, mediante la generación de contenidos, lo constituyen las redes sociales, herramientas clave para que las marcas se relacionen en la actualidad. Metodología: mediante metodología cuantitativa, a través de análisis de contenido, se analiza un corpus de mensajes emitidos en Twitter durante doce meses por diez marcas responsables, seleccionadas mediante el Monitor Empresarial de Reputación Corporativa. Resultados: se obtienen datos relevantes sobre los contenidos generados por estas marcas en sus perfiles de Twitter que indican que comunican principalmente poniendo el foco en el servicio que ofrecen y sus productos.  Discusión: los resultados revelan que las marcas estudiadas generalmente toman una posición centrada en la propia empresa o en el producto. Conclusiones: aunque existe una tendencia por parte de las organizaciones a generar un beneficio social a través de sus actuaciones, esta investigación indica que el enfoque que estas empresas dan a su comunicación en Twitter no está orientado a las personas principalmente.
Об аппроксимации булевых функций линейными разветвлениями
Authors: Veligura A N
Published: May 2023

Рассматриваются приближения булевых функций линейными разветвлениями - кусочно-линейными булевыми функциями, области линейности которых являются линейными многообразиями. Найдено представление расстояния от линейного разветвления до булевой функции через ее спектральные коэффициенты, предложен алгоритм построения ближайшего к данной функции линейного разветвления для заданного разветвляющего отображения.
Об одном методе построения следствий специального вида для систем булевых уравнений
Authors: Tarasov Alexey Vyacheslavovich
Published: May 2023

Излагается подход к решению систем булевых уравнений, основанный на использовании биюнктивных имплицент. Предложен базовый алгоритм нахождения таких имплицент и рассмотрен вопрос об одновыполнимости построенной системы.
Caractérisation de variétés biofortifiées en fer et zinc et variétés locales de haricot commun
Authors: Kataliko R.K. , Mbahingana G.K. , Muhongya E.F. , Muyandula J.M. , Ndaliko T.M. , Wasukundi M. , Kimani P.M. , Ofori K.
Published: May 2023

La déficience en fer et en zinc est connue comme la «faim cachée» en raison du fait de l’absence de symptômes reconnus aux premiers stades. Bien que la déficience en fer est la plus prévalente, le zinc est aussi impliqué dans l’inhibition de la réplication des virus, le corona virus (COVID-19) inclus. Au Nord-Kivu et au Sud-Kivu en République Démocratique du Congo, les zones où plus de 50 % des haricots (Phaseolus vulgaris) sont produits et consommés, 36% et 47% des enfants d’âge préscolaire sont anémiés suite aux carences en fer. Ce paradoxe est dû à l’insuffisance des mets riches en fer dans les habitudes alimentaires. L’objectif de cette étude est de caractériser 59 variétés biofortifiées en fer et zinc en présence de six variétés locales de haricot commun pour ainsi les intégrer éventuellement dans un programme de sélection variétale en ville de Butembo, en République Démocratique du Congo. La caractérisation porte sur 15 paramètres qualitatifs et cinq paramètres quantitatifs. Les paramètres qualitatifs ont permis de distinguer les différents morphotypes et de regrouper ces variétés en différents clusters. A part la statistique descriptive, les données quantitatives ont servi à établir une corrélation (de Pearson) et à l’analyse des composants multiples, PCA. Les paramètres qualitatifs ont permis de grouper les génotypes en étude en 14 morphotypes d’après l’aspect et la couleur du tégument, la couleur tout autour du hile et la taille des graines. Le clustering a regroupé les 65 génotypes en étude en 12 clusters. Les génotypes appartenant à un même cluster ont des caractères plus similaires. Les résultats des paramètres quantitatifs ont montré des différences significatives au regard des génotypes en étude (P=0.00). Une corrélation positive s’est observée entre le nombre de jours jusqu’à la floraison et le nombre de jours jusqu’à la maturité (P<0.05), mais aussi entre le nombre de gousses par plant et le nombre de jours jusqu’à la floraison. Une observation similaire existe également entre le nombre de gousses par plant et le nombre de graines par gousse (P<0.01). Une corrélation négative est par contre observée entre le poids de 100 graines et le nombre de graines par gousse. Les résultats de PCA représentés sur deux axes perpendiculaires ont montré 64.1% de la variance totale dont 42.3% est expliquée par le premier axe et 21.8% par le deuxième axe. Ces résultats montrent que les génotypes en étude sont morphologiquement et quantitativement différents qu’ils peuvent être utilisés dans un programme de sélection variétale.
Complexation of some alkaline earth metals with bidentate uracil ligand: Synthesis, spectroscopic and antimicrobial analysis
Authors: A.O. Younes Ayman , S. Refat Moamen , A. Saad Hosam , Majid A. Adam Abdel , M. Alzoghibi Omar , M. Alsulaim Ghayah , Mohammed Alsuhaibani Amnah
Published: May 2023

ABSTRACT. Magnesium, calcium, strontium, and barium complexes of uracil were prepared in a 2:1 ligand to metal ratio to investigate the ligational character of the uracil (Ura). The modes of chelation were explained depending on elemental analyses, FT. IR, 1H–NMR spectra as well as scanning electron microscopy. Uracil has two donation sites either through N(3) and C(2)=O, or through N(3) and C(4)=O with the molecular formulas [M(Ura)2(H2O)2]Cl2 where M = Mg(II), Ca(II), Sr(II) and Ba(II) . The morphological surface and particle size of uracil metal complexes were determined using SEM and TEM. The thermal behaviors of the complexes were studied by the TGA (DTG) technique. The data obtained agreed well the proposed structures and showed that the complexes were finally decomposed to the corresponding metal oxide. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz–Metzger methods. The negative values of  deduced the ordered structures of the prepared complexes compared to their starting reactants. Antibacterial activity of ligands and complexes is evaluated with two types of bacteria Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) by the agar-well diffusion technique using DMSO as a solvent.

 

KEY WORDS: Uracil, Coordination compounds, Non-isothermal kinetic parameters, Elemental analysis, Spectral studies, Biological efficiency

Bull. Chem. Soc. Ethiop. 2023, 37(4), 945-957.                                                              

DOI: https://dx.doi.org/10.4314/bcse.v37i4.11
Modern teaching strategies and mathematics academic achievement among junior secondary school students in post– covid–19 era in calabar education zone, cross river state, nigeria.
Authors: Meremikwu Anne , Olunwa Ekwueme Cecilia , Abua Opoh David
Published: May 2023

This study assess modern teaching strategies and mathematics academic achievement among junior secondary school students in post– covid–19 era in Calabar education zone, Cross River State, Nigeria. Three research questions and hypotheses were formulated to provide focus and to direct the study. The design of this study is quasi-experiment design involving pre-test-post-test. The sampling technique adopted in the study was a simple random sampling technique. The sample comprised of 90 Junior Secondary School III Mathematics Students. Two instruments were used for data collection; the first involved the design of one instructional package on modern teaching strategies and the second instrument was a Mathematics Achievement Test (MAT). The experimental group was taught using modern teaching strategies while the control group was taught using the conventional teaching method. The data obtained were analysed using analysis of covariance (ANCOVA). The result revealed that students taught with innovative teaching strategies, modern technologies and using of mother tongue outperformed those taught using the conventional teaching method. It was recommended that school administrators and government should organize workshops to introduce teachers to modern teaching strategies using innovative teaching, modern technology and using of mother tongue to enhance learning. Efforts should be made to provide well-equipped mathematics laboratory to junior secondary schools to support these modern teaching approaches.
Parental involvement and school indiscipline among secondary school students in calabar south local government area of cross river state, nigeria
Authors: Ndifon Bekomson Achi , E Oyoita Margaret , Claimz Enamhe Dorn
Published: May 2023

Indiscipline in secondary school has persisted over the years, taking a new and frightening tone that seems like a bone in the throat. This study investigated the influence of parental involvement in terms of interference with child punishment and confronting teachers openly on school discipline of secondary school students. Two research questions were raised to guide the study. The literature review was done according to the variables under study. The survey design was adopted for the study. The population consists of all parents of Public Secondary Schools. Ninety three (93) parents purposively selected from the Parents Teachers Association of the 7 Public Secondary Schools in Calabar South Local Government Area of Cross River State constituted the sample for the study. A Four (4) point Likert questionnaire titled “Parental Involvement and School Indiscipline Questionnaire"(PIASDQ) was the instrument used for data collection. The validity of the instrument was determined by four (4) experts in Educational Psychology and Measurement and Evaluation units respectively, all from the Department of Educational Foundations. While Crunbach Alpha reliability was used to determine the reliability at .73 level of significance. Data collected were analyzed using descriptive statistics. Based on the findings, it was recommended among others that parents should be encouraged to correct their children's wrongdoings at home as the home is the first school, modalities for effective disciplinary measures should be discussed strongly in PTA meetings to get the views of parents, and also check brutality on the part of the teachers.
Managing nonteaching staff for institutional best practices and goal achievement in public secondary schools in benue state, nigeria
Authors: Abigail Gire Fanan , Patrick Ogar Ategwu , ALICE N EKPO
Published: May 2023

Educational institutions target academic excellence through teaching and learning; to attain this, institutions employ best practices in handling teaching and nonteaching staff towards achievement of educational goals been teaching and learning. This study examines the extent of influence managing nonteaching staff in public secondary schools have on institutional best practices and goal achievement in boarding schools in the era of Covid 19. Specifically, the extent of influence of managing boarding master/mistress and cleaners has on institutional best practices and goal achievement. Two research questions and two hypotheses guided the study. The population of the study comprised 1,054 secondary school teachers drawn from 302 public secondary schools in Benue State. Out of which 350 teachers were randomly sampled. A self-structured questionnaire titled “Nonteaching staff and Best practices for Goal achievement Rating Scale (NBGRS)” was used to collect data for the study. Data collected was analysed using descriptive statistics of mean and standard deviation to answer the research questions while, Chi-square test of goodness of fit was used in testing the hypotheses at 0.05 alpha level of significance. Findings of the study revealed that managing boarding master/mistress and cleaners significantly influences institutional best practices and goal achievement in secondary schools. Recommendations were that; school administrators should build capacity through training and retraining of nonteaching staff in all aspects of Covid 19; for institutional best practices to be upheld for overall goal achievement in secondary schools.
Environmental pollution as health depreciator: the case of household generator use in nigeria
Authors: O C Odeyale , O O Oke , A R Falana , A S Adeoye , J O Ogunsola , J T Marizu
Published: May 2023

The peculiarities of poor electricity generation and distribution which has resulted in high reliance on generators is implicated in the profile of Nigeria’s environmental pollution situation. Still, the consequences of the pervasive use of generators on health is yet to be optimally captured empirically, and macro-wise. Hence, this work was designed to examine correlations between generator use and some selected indices of- health. depreciator. Cross national, secondary data used were extracted from the 2018/19 Nigerian General Household Survey Panel Component (the 2018/19 GHS-Panel). Data on generator use and some selected indices of ill-health were subjected to descriptive and Spearman rank correlational analysis. Results indicated that generator is owned in 24.6% of Nigerian households. Only 55.4% of households have access to electricity; 11.3% and 12.4% of them primarily and secondarily rely on generators respectively. Male and female respondents reporting any health problem was 22.6% and 22.5% respectively, of which only 20.5% consulted a health practitioner. Respondents reporting drug purchase were 28.8%.  Primary reliance on generator significantly and positively correlated with consultation with health practitioner (r = .879, p< 0.05), female health problems (r = .862, p< 0.05), drug purchase (r = .700, p< 0.05), cost of medication (r = .700, p< 0.05), male health problems (r = .667, p = 0.05) and cost of consultation (r = .667, p = 0.05). On the other hand, the use of generator as a secondary or other source of electricity is only significantly and positively related to cost of medication (r = .733, p< 0.05) and drug purchase (r = .717, p< 0.05). Generators are leading assets whose use is becoming a significant element of the Nigerian way of life. Marginal or zero reliance on generator for access to electricity would have kept the Nigerian people healthier than they are currently. Certainly, generator use is a vast sponsor of ill-health and a vicious depreciator of health in Nigeria.
On the use of arima and garch in modelling nigeria’s naira – us dollar monthly exchange rates
Authors: Nafisat Tanko Ahmad , G K Musa , Salisu Auta Musa
Published: May 2023

This paper aimed at modelling the volatility of monthly average official exchange rate (Naira/USD) using the Autoregressive Integrated Moving Average (ARIMA) and Generalized Autoregressive Conditional Heteroscedasticity (GARCH) for the period January, 1981 to December, 2021. The data for the study was obtained from Central Bank of Nigeria 2021 Statistical Bulletin. The time plot, Augmented Dickey Fuller (ADF) and Phillip’s Perron (PP) were used to check for the Stationarity of the Series. It was discovered that the series is not stationary, thus the need for differencing to make it stationary. Based on the findings of the study, it was concluded that the ARIMA (0, 2,2) and GARCH (1,1) with Student’s t-distribution are the optimal models for modeling monthly average official exchange rates return (Naira/USD) in Nigeria.
Vegetative growth, yield quality, and phytochemical accumulation of Abelmoshus esculentus L. (Moench) influenced by priming with potassium nitrate
Authors: Olowolaju E. D. , Afolabi A.M. , Popoola K. M. , Ologundudu A. F.
Published: May 2023

Seed priming is a promising technique that can improve the growth and yield of plants under optimum conditions. The specific priming duration and concentration required for adequate vegetative growth, yield quality, and phytochemical accumulation of Abelmoshus esculentus need clarification. This study was evaluated under screen house conditions, using a completely randomized design (CRD) approach. The seeds of Abelmoshus esculentus were subjected to priming with potassium nitrate for 6 and 12 h duration at a concentration of 0.5 and 1.00 mM while unprimed seeds served as the control. The results revealed that the primed seeds showed improved vegetative growth, yield components, and phytochemical constituents compared to the unprimed control seeds. This observation was irrespective of the priming duration and concentration of potassium nitrate used. Moreover, seeds primed for a 6 h duration at 1 mM were significantly higher in yield, fruit mineral, and phytochemical constituents compared to other treatments. At 12 h priming duration, seeds primed in 0.5 mM of potassium nitrate had higher growth and yield than at 1 mM. Priming with inorganic salts such as KNO3 induces faster growth and maximum crop yield of Abelmoshus esculentus. Priming for a short duration (6 h) 3 and at high concentration is sufficient to enhance the growth process and increased yield of Abelmoshus esculentus and has practical implications in the production of Abelmoshus esculentus .
The histostereological teratogenic effects of in-utero exposure to varied doses of lamotrigine on the developing fetal brain in albino rats (Rattus Norvegicus)
Authors: Mwangi Ann Wairimu , Kweri Joseph Kariuki , Kweri Cyrus Kamau , Kanyoni James Mangi , Kigundu Alex Muriithi , Mwangi Elijah Githinji , Marera Dominic Oduor
Published: May 2023

The histoqualitative teratogenic effects of lamotrigine, a second-line anticonvulsant medicine, on the developing fetal brain structures when exposed in  utero in a time- and dose-dependent manner remain unclear. On the other hand, lamotrigine is currently being widely prescribed as a first-line medicine  in the management of maternal conditions like epileptic seizures and bipolar disorders, among others. The preferential use of lamotrigine is attributed to  the considerations of its efficacy, tolerability, and minimal teratogenic effects on fetal organs like the brain, among others, though with insufficient  supportive data. The aim of this study was therefore to evaluate the histo-quantitative effects of lamotrigine on the developing fetal brain structures  when exposed in utero at varying dosages during different trimesters. The study adopted a post-test only experimental study design where a sample size  of 30 sexually mature albino rat dams of the species (Rattus norvegicus) weighing between 250 + 30 grams was used. The rats were divided into two  broad groups: 3 control rats and 27 dosage rats. The data collected was coded in Excel spreadsheets and analyzed in SPSS. Results were expressed as the mean + standard error of the mean (SEM), and values with a P < 0.05 were considered to be significant. Study findings depicted a reduction in brain  weights, length, width, volumes, and volume densities of cortical and subcortical layers in a dose- and time-dependent manner. High lamotrigine  dosages, especially during the first and second trimesters, were observed to be associated with significant mean reductions in the brain weights, length,  width, volumes, and volume densities of the developing fetal brain structures. Therefore, further studies with higher primates closer to the human  species as well as clinical trials are recommended to rule out the safety index of lamotrigine during pregnancy.
Cytotoxic and alpha amylase-inhibitory metabolites from Tagetes minuta: In vitro evaluation and docking studies
Authors: Mohamed Gamal A , Alqarni Ali A , Abdallah Hossam M , Omar Abdelsattar M , Ibrahim Sabrin RM
Published: May 2023

Purpose: To investigate the cytotoxic and alpha-amylase inhibitory (AAI) potential of methanol (MeOH) extract of T. minuta and its isolated metabolites.

Methods: Phytochemical investigation of MeOH extract of the aerial parts of T. minuta was accomplished using SiO2 and Rp-18 column chromatography (CC). The structures of the isolated metabolites were determined and verified based on various data, in addition to comparison with literature data. The metabolites were assessed for cytotoxic potential against HepG2, MCF-7, and HCT116 cell lines utilizing sulphur rhodamine B (SRB) assay. The in vitro AAI potential of the metabolites were also assayed, and the findings were confirmed using results from molecular docking studies.

Results: One thiophene (compound 1), one coumarin (compound 2), and three phenolic compounds (compounds 3-5) were isolated and characterized. Compound 1 exhibited a marked cytotoxic effect (IC50 values: 2.7 – 7.3 μM) on HepG2, MCF-7, and HCT116 cell lines, relative to doxorubicin (IC50 values: 0.18 - 0.60 μM), whereas compound 2 had a moderate cytotoxic effect on MCF-7 (IC50 17.7 μM). Besides, compounds 4 and 5 produced potent AAI effects, with IC50 values of 12.3 and 9.2 μM, respectively, and 91.8 and 94.7 % inhibition, respectively), when compared to acarbose (94.7 % inhibition and IC50 of 7.1 μM). Interestingly, the in vitro AAI and in silico results were in agreement with each other. Compounds 5 and 4 had more negative docking scores (-13.655 and -12.135 kcal/mol, respectively) than the native inhibitors, myricetin (-12.155 kcal/mol) and acarbose (-15.105 kcal/mol).

Conclusion: These results suggest that T. minuta is a valuable source of anti-diabetic and cytotoxic metabolites. However, there is a need to validate these results through additional in vivo and in vitro investigations.
Comparison of nerve block anesthesia and local infiltration anesthesia with lidocaine hydrochloride in primary root canal treatment of mandibular molars
Authors: Geng Shuangshuang , Wang Jian , Bai Xiaobei , Hou Yan , Li Junke , Ban Jiandong
Published: May 2023

Purpose: To investigate and compare the analgesic effects of nerve block anesthesia and local infiltration anesthesia in one-visit root canal therapy of mandibular molars.

Methods: A total of 120 patients who underwent one-visit root canal therapy for mandibular molars were divided into nerve block group (n = 76) and local infiltration group (n = 44). Lidocaine was used to anesthetize the two groups. Perioperative heart rate (HR), diastolic blood pressure (DBP) and systolic blood pressure (SBP) were determined in the two groups. Visual analogue scale (VAS) and Ramsay sedation scale were used to assess postoperative pain and sedation in the two groups. The occurrence of adverse reactions was also compared.

Results: The success rate of the anesthesia in the nerve block group was significantly higher than that in local infiltration group (9 7.37 vs 88.64 %; p < 0.05). There were no significant differences in HR, DBP and SBP levels between the two groups. Over time, VAS and Ramsay scores decreased in both groups, while the VAS and Ramsay scores in the nerve block group were significantly lower than those in the local infiltration group (p < 0.05). The incidence of adverse reactions in the nerve block group was 5.26 %, which was not significantly different from 13.64 % incidence rate in local infiltration group (p > 0.05).

Conclusion: Both anesthesia methods have little effect on hemodynamics in patients undergoing one-visit root canal therapy for mandibular molars, but lidocaine nerve block anesthesia is more effective and has stronger analgesic and sedative effects than lidocaine local infiltration anesthesia.
Entecavir/peginterferon alfa-2a combination in the treatment of two genotypes of chronic hepatitis B patients with lamivudine resistance
Authors: Peng Xiaoyun , Chen Longgui , Xiao Mingying
Published: May 2023

Purpose: To investigate the efficacy of entecavir plus peginterferon alfa-2a in the treatment of chronic hepatitis B (CHB) patients with different hepatitis B virus (HBV) genotypes resistant to lamivudine (LAM).

Methods: 119 LAM-resistant CHB patients treated in Baoshan People's Hospital from May 2018 to May 2020 were selected. All patients received entecavir and peginterferon alfa-2a for 24 months and were scheduled for regular outpatient review and telephone follow-up. Polymerase chain reaction (PCR) was conducted to determine the HBV genotype and HBV-DNA clearance. Alanine aminotransferase (ALT) normalization rate, HBV-DNA clearance rates, and hepatitis B e-antigen (HBeAg) seroconversion rate were determined in CHB patients with different genotypes. Quality of life for all patients was assessed using SF-36 Scale.

Results: Five out of 119 patients were lost during follow-up, with a follow-up rate of 95.80 %. Two HBV genotypes were identified, of which 42 (36.8 %) were type B and 72 (63.2 %) type C. At the 6th and 12th month of follow-up, the HBV-DNA clearance rate, ALT normalization rate, and HBeAg seroconversion rate were significantly higher in CHB patients with genotype B than in patients with genotype C (p < 0.05). There were no significant differences between the three rates in the two groups at 18th and 24th month of follow-up (p > 0.05). The quality of life (QOL) of the patients differed between the two groups (p < 0.05).

Conclusion: Entecavir plus peginterferon alfa-2a are effective in treating LAM-resistant CHB patients with different genotypes. Genotype B CHB patients are more suitable for this combination protocol.
Anesthetic effect of sufentanil in patients undergoing cardiovascular surgery
Authors: Yuan Cheng , Wang Dan , Cheng Qing
Published: May 2023

Purpose: To investigate the effect of sufentanil on anesthesia in patients undergoing cardiovascular surgery.

Methods: The subjects comprised a total of 100 patients who were scheduled to undergo cardiovascular surgery in Taikang Tongji (Wuhan) Hospital from January 2021 to December 2021 and met the inclusion criteria. The eligible patients were assigned in a ratio of 1:1 to receive either remifentanil (control group) or sufentanil (study group) during cardiovascular surgery, with 50 patients in each group. The anesthetic effect of remifentanil and sufentanil was compared.

Results: Patients treated with sufentanil experienced a faster onset of anesthesia and a shorter time-lapse before extubation, postoperative spontaneous breathing recovery, and postoperative anesthesia recovery when compared with those administered with remifentanil (p < 0.05). Sufentanil provided more potent pain mitigation for patients undergoing cardiovascular surgery than remifentanil, as shown by the lower visual analogue scale (VAS) scores of patients in the study group (p < 0.05). Patients administered with sufentanil showed better levels of mean arterial pressure (MAP) and oxygen saturation (SpO2) than remifentanil, suggesting better hemodynamic benefits provided by sufentanil (p < 0.01). During cardiovascular surgery performed in this study, sufentanil resulted in a higher safety profile by reducing significantly the incidence of adverse reactions (6 %) than remifentanil (30 %) (p < 0.01).

Conclusions: Sufentanil exhibits a better anesthetic effect in patients undergoing cardiovascular surgery than remifentanil. It provides potent pain mitigation, effectively ameliorates patients’ hemodynamic status, and reduces the risk of adverse reactions. Future studies with larger sample sizes are required to validate these findings.
HMGB1-mediated-TLR4/MyD88 signaling regulates cell proliferation, migration and invasion in esophageal squamous cell carcinoma
Authors: Liang Xuyang , Ma Yanqin , Zhang Zhimei , Xu Dazhou , Lv Shengxiang , He Yanling , Zhang Shuxian , Ren Ling , Xu Ping
Published: May 2023

Purpose: To study the effect of high mobility group box protein 1 (HMGB1)-mediated toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) on esophageal squamous cell carcinoma (ESCC).

Methods: Cell viability was determined using CCK-8 test and colony formation assay, while cell migration and invasion were assessed by Transwell assay. Western blotting was used to determine protein and mRNA expression levels. The effect of TLR4/MyD88 signaling pathway on proliferation of ESCC cells was investigated via in vitro knockdown of HMGB1.

Results: Data from in vitro experiments indicated that HMGB1 knockdown significantly decreased the proliferation, migration, and invasion of EC9706 cells in siHMGB1 group, when compared with siNC group (number of invasive cells in siHMGB1 vs. corresponding number in siNC: 26.7 ± 4.5 vs. 68.7 ± 2.5; p < 0.01), and also decreased proliferation, migration and invasion of TE-9 cells in siHMB1, relative to siNC group (number of invasive cells in siHMGB1 vs. corresponding number in siNC: 29.3 ± 3.5 vs. 55.7 ± 3.1; p < 0.01). Moreover, MGB1 knockdown via siTLR4 transfection significantly down-regulated the expressions of TLR4/MyD88 and epithelial-mesenchymal transition (EMT), but over-expression of TLR4 reversed the inhibition by HMGB1 knockdown on ESCC cells (p < 0.01).

Conclusion: These findings suggest that HMGB1-mediated TLR4/MyD88 signal pathway is a potential treatment route for ESCC.
Long non-coding RNA reprogramming (LncRNA-ROR) attenuate inflammation induced by LPS through the regulation of miRNA-124-3p and inhibition of C5a and TLR4/Myd88/NF-κB pathwaysin C28/12 cells
Authors: Lu Wei , Yao Jing , Cheng Yu , Mao Dongmei , Luo Di , Wang Lin
Published: May 2023

Purpose: Osteoarthritis (OA), inflammation of joint and articular cartilage, is a serious joint disorder and a major cause of pain and disability. LncRNAs exert their role in OA progression. The purpose of this present research is to investigate the impact and molecular mechanism of lncRNA regulator of reprogramming (LncRNA-ROR) on inflammatory damage induced by lipopolysaccharide (LPS) in C28/12 cells.

Methods: The expressions of lncRNA-ROR and miR-124-3p and the mRNA expressions of COX-2, iNOS, IL-8, C5a, and TNF-α were determined in C28/12 cells stimulated with LPS using RT-qPCR. Viability of C28/12 cells was evaluated using CCK-8 assay and C28/12 cell apoptosis was assessed by flow cytometry in LPS-induced C28/12 cells. Moreover, the concentration of IL-8, C5a, and TNF-α and the protein expressions of TLR4/Myd88/NF-κB pathways were examined using Elisa assay.

Results: Results revealed that LPS inhibited the proliferation, enhanced rate of cell apoptosis, and promoted mRNA expressions of iNOS, IL-8, C5a, and TNF-α in C28/12 cells. Besides, the expression of lncRNA-ROR was expressively reduced in C28/12 cells stimulated with LPS and the lncRNA-ROR overexpression markedly reduced the inflammatory injury stimulated by LPS in C28/12 cells. Besides, lncRNA-ROR significantly down-regulated the miR-124-3p expression and miR-124-3p exposure inhibited the protecting impact of lncRNA-ROR on LPS-induced C28/12 cells. Furthermore, lncRNA-ROR suppressed the TLR4/Myd88/NF-κB pathways via suppressing the expression of miR-124-3p in LPS-induced C28/12 cells.

Conclusion: The finding revealed that lncRNA-ROR protected against LPS-stimulated inflammatory injury in C28/12 cells by suppressing TLR4/Myd88/NF-κB pathways via inhibiting miR-124-3p suggested an efficient therapeutic strategy for OA treatment.
Analisis Indeks Keragaman Hasil Tangkapan pada Rumpon Berbasis Sumberdaya Lokal di Perairan Kuala Daya Kabupaten Aceh Jaya
Authors: Rahayu Melisa , Rizal Muhammad , Hafinuddin Hafinuddin , Bahri Samsul , Khairi Ikhsanul , Fuadi Afdhal , Zakaria Mursyidin , Sarong Muhammad Ali
Published: May 2023

Rumpon merupakan alat bantu yang berfungsi sebagai tempat berkumpulnya ikan sehingga mempermudah nelayan dalam mencari ikan. Penelitian ini bertujuan untuk mengetahui indeks keragaman, dominansi serta bobot dan panjang ikan hasil tangkapan pada rumpon berbasis sumberdaya lokal. Hasil penelitian ini diharapkan dapat memberikan informasi mengenai jenis-jenis ikan yang tertangkap dengan menggunakan pancing ulur. Penelitian dilakukan pada bulan Agustus sampai bulan Desember 2022 di perairan Kuala Daya Kabupaten Aceh Jaya. Data yang dikumpulkan berupa data jumlah ikan (ekor), bobot (gr) dan panjang (cm). Metode pengumpulan data yang dilakukan adalah eksperimental fishing selama 4 trip pada dua lokasi berbeda. Selama penelitian jumlah hasil tangkapan yang diperoleh sebanyak 14 ekor ikan yang terdiri dari 1 filum (chordata), 1 kelas (actinopterygii), 1 ordo, 4 famili dan 7 spesies, adapun jenis ikan yaitu kuwe/rambai (Carangoides malabaricus), selar hijau (Atule mate), selar ekor kuning (Selaroides leptolepis), kerapu macan (Ephinephelus coioides), swanggi (Priachantus hamrur), kakap merah (Lutjanus malabaricus), tenggiri papan (Scomberomorus commerson). Hasil penelitian menunjukkan bahwa nilai indeks keragaman pada rumpon 1 dan rumpon 2 adalah sebesar 1,33 dan 1,21 yaitu termasuk dalam kriteria relatif sedang. Nilai indeks dominansi pada kedua rumpon adalah sebesar 2 dan 2 yaitu termasuk dalam kriteria relatif tinggi, serta bobot ikan hasil tangkapan pada kedua rumpon adalah sebesar 2,72 kilogram dan 1,91 kilogram dan panjang rata – rata ikan hasil tangkapan pada kedua rumpon adalah berkisar antara 14,4 cm – 40,25 cm dan 20,9 – 40,5 cm.
An Interventive Collaborative Scaffolded Approach with a Writing Center On ESL Students’ Academic Writing
Authors: Mdodana-Zide Lulama , Mafugu Tafirenyika
Published: May 2023

The expected transition in higher education from students’ school-level assignments to university-level assignments provides challenges and development prospects for students and the academic world. Academic support programs have been introduced in South African higher universities to assist under-prepared university students to benefit from lectures, writing centers, and tutorials. However, the problem of poor academic writing by university students persists. The study aimed to examine students’ academic writing difficulties. English Second Language (ESL) students’ university-level writing experience, and the impact of a collaborative approach between a lecturer and a South African university writing center, to support ESL students with their academic writing, was explored. The study used the Scaffolding theory as a lens. The mixed methods approach was used, with data collected in three phases, comprising a pretest, posttest, and questionnaire. A sample of 216 first-year Senior Phase and FET students were chosen. Findings revealed that ESL students experienced challenges in academic writing skills such as structure, organization, coherence, table of contents, paraphrasing, referencing, and in-text citations. The collaborative intervention between a lecturer and the writing center assisted students to progress in their academic writing. The paper recommends exploring more collaborative strategies between lecturers and writing centers, to optimally support students.
Performance of kits that born in semi-group housing system or individual cages before and after weaning
Authors: Machado Luiz , Martínez-Paredes Eugenio , Cervera Concepcion , Garcia Arantxa
Published: May 2023

Animal welfare is a subject of great interest and the housing of rabbit does in semi-group housing system is under investigation, but there is a lack of information about the effect on performance of kits in this system. A total of 1362 crossbred kits from the first four cycles of 48 rabbit does housed in semi-group housing system (24 does, six per pen, parttime system) and individual cages (24 does) were allocated at weaning into wire mesh cages (50 × 80 × 34 cm), eight kits per cage, maintaining or not the original litter (mixed or non-mixed). The kits were weighed at 18, 28 (weaning) and 56 d of age and their performance was evaluated. The feed intake (FI) of jointly does and kits was measured during the periods kindling – 18 lactation days (K-18L) and 18 days until weaning (18LW). Kits from semi-group housing system were heavier at 18 d (300 vs 293 g, P≤0.01) being this related to a higher FI in the period K-18L (P≤0.05). Regrouping had a negative impact on the feed consumption of animals housed in semi-group housing system, so in the period 18L-W the FI in individual cages was higher (499 vs 526 g, P≤0.01). No differences were observed in kits’ weight at 28 and 56 days, feed intake, daily weight gain or feed conversion ratio, and mortality of kits. In conclusions, no residual effect of the housing system was recorded on fattening rabbits performance and, considering performance aspects, kits from semi-group housing system can be housed litter-mixed or non-mixed in fattening cages.
Georreferenciamento com o QGIS 3.20
Authors: Clifford Jim , MacFadyen Josh , Macfarlane Daniel
Published: May 2023

Nesta lição aprenderá como georreferenciar mapas históricos para que possam ser adicionados a um SIG como uma camada raster.
Gel of Betel (Areca Catechu Linn.) Nut Ethanol Extract Activity Test as Cuts Healing against Diabetic Rabbits (Oryctolagus cuniculus)
Authors: Gunawan Elsye , Silvia Mega , Bakri Nur Fadilah
Published: May 2023

Background: Areca nut (Areca catechu Linn.) contains the main components in the form of tannins, flavonoids, alkaloids, and saponins. People usually use the young betel nut as cuts medicine by mashing it and applying it directly to the cuts cut area or by boiling the betel nut and the boiled water is used to clean cuts and other skin infections. Objective: The purpose of this study was to determine the effect of giving betel nut (Areca catechu Linn.) ethanol extract gel and to determine the most effective concentration of cuts healing in diabetic rabbits (Oryctolagus cuniculus). Method: This study used 6 treatment groups, namely the group that was given a gel with an extract concentration of 1%, 3%, and 5%, a group that was given conventional preparations as a positive control, a group that was given a gel base as a negative control, and a group that was not given the test substance. The rabbit's back area was anesthetized with 2% lidocaine subcutaneously and a 2 cm long incision was made with a depth of 1.5 mm using a scalpel. The data obtained were the percentage of cuts healing in diabetic rabbits which were analyzed using One-way ANOVA. Results: The results showed that the percentage of cuts healing was 100% healed on gel treatment with 1% areca nut ethanol extract on the 11th day, gel with 3% betel nut ethanol extract on the 11th day, and gel with 5% betel nut ethanol extract on the 10th day. The results of One-way ANOVA statistical analysis showed a significant difference in the cuts healing effect of diabetic rabbits in each treatment with a value of p = 0.000 (p <0.05). Conclusion: The results of the study concluded that areca nut has activity in cuts healing in diabetic rabbits which was formulated in the form of a gel with an extract concentration of 5%.
DesignPaperforProctoredExamSystemUsingVideoAuthentication
Authors: Vinay S Nalawade , Aditi A Kulkarni , Sakshi S Pathak , Chaitrali N Gavali
Published: May 2023

In the past two years, due to the COVID-19 situation, there has been a need for variousonline examinations which were conducted byvarious universities across the world..Thus,the use of machine learningtools and various other educational tools that can be operatedremotely has been used continuously to increase reach among people who don't have access to organisations. Exams area more important factor in the educational system,an online learningprocessinthestudent's career.Sincebyvariousmethodshave been invented to provide efficient, comfortable onlineexamproctoringtoreducemalpracticeintheexaminationbythe student.Various malpracticescan be donefromthe studentsidewhichshouldbehalted.Forthatvariousdeliverytoolsaswellassystemshavebeencreatedtoconducttheexamsinonlinemodefromanyoftheplaces.Those toolswill help to reduce time consumption. This paper introducesa new approach for the "Online Exam Proctoring system” using theHaar cascadealgorithm. Thus,bythissystemthereisnotonly assurance for the identification of a test-taker but also theoverallintegrityofthe testthereshouldbetransparencyinthesystembecause mainly online exam security is a major concern. In thissystem, there is the usage of Haarcascade algorithm which will beused for the feature extraction and will give the system accuracy to enhance the exam security and to minimize the stressfulrestrictions.
A Comparative Study of Vetiver Grass and Lemon Grass Using Phytoremediation Technique for Waste Water Treatment
Authors: Paramesh Anjana , Abraham Reena
Published: May 2023

The increase in population led to a scarcity of water. There are lots of diseases and problems that are affecting the environment and human life. This is increasing day by day. This causes lots of hazards in our world. To treat wastewater, we have lots of methods. In spite of this, it is very expensive, not affordable to the masses, and also not properly treated; therefore, we use natural methods to treat the wastewater in a way that does not harm our environment. To avoid this situation, there is a solution: using vetiver grass and lemon grass to treat wastewater. As a result of this method, we are able to determine a number of parameters, such as pH, turbidity, conductivity, alkalinity, DO, BOD, COD, and T.T. The coliforms are analyzed to identify changes before and after treatment. With the rapid growth of urbanization and industrialization, there is a high intake of water and a great generation of wastewater. This study aims to find the most cost-effective method for wastewater treatment and compare it to the conventional method of wastewater treatment. The conventional method is not suitable in rural areas as it is highly expensive. The foundation and improvement of a healthy life through water are two of the most important fundamentals. Using vetiver and lemon grass for wastewater treatment has been proven to be a sustainable and cost-effective alternative to conventional wastewater treatment technologies. In this study, an attempt is made to find the effectiveness of vetiver grass and lemon grass in a laboratory for pollutant removal from wastewater. Various characteristics of wastewater before and after treatment have been checked to study the comparative effectiveness of these two plants. Removal efficiencies of parameters like pH, conductivity, chemical oxygen demand, biological oxygen demand, dissolved oxygen, total coliform, turbidity, and E. coli are analysed.