bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital technologies in the educational process of educational institutions: Proceedings of the X All-Ukrainian Interactive Scientific and Practical Conference
Authors:   Institute for Digitalization of Education,   Institute of Education Content Modernization,   Rivne Regional Institute of Postgraduate Pedagogical Education
Published: February 2023

The collection contains the materials of the 10th All-Ukrainian interactive scientific and practical conference "Digital technologies in the educational process of educational institutions", which was held from September 27 to October 27, 2021 in cooperation with the State Scientific Institution "Institute of education content modernization", the Institute for Digitalisation of Education of the NAES of Ukraine and Rivne Regional Institute of Postgraduate Pedagogical Education. The collection highlights the problems of creating, popularizing and practical use of digital learning tools and filling them with high-quality educational content, its features, quality and accessibility for use, compliance with program requirements, uniformity, informativeness, etc. are determined. It is recommended for pedagogical and research-pedagogical workers of postgraduate pedagogical education institutions, managers and teachers of educational institutions.
Un breve análisis de la diseminación de la información en redes informáticas a partir de modelos epidemiológicos
Authors: Cortés Castillo Antonio , Signes Pont María Teresa
Published: February 2023

Actualmente uno de los activos más valiosos en las redes informáticas son los datos que viajan a través de los diversos nodos que componen las topologías de redes. En la mayoría de los casos, la presencia de grandes volúmenes de datos en las redes, permiten que estos se dañen debido a la alteración de la información por algún tipo de virus, malware o troyano lo que genera en una propagación de una enfermedad en la red. Ante esta situación, planteamos el uso de un modelo clásico de enfermedad infecciosa basado en SEIRS, el cual permite plantear un marco de espacio – tiempo discreto para la expansión de la enfermedad. Se consideran tres tipos de conectividad que se representan a través de una relación de vecindad para la que se utiliza una rejilla de tamaño n x n. Los tipos de vecindario considerados son los de Von Neumann, Moore y L. Específicamente, el uso de reglas locales y el tipo de vecindario definen la dinámica de expansión de la enfermedad infecciosa. Luego presentamos un acercamiento a la evolución de modelos deterministas de ecuaciones diferenciales (ODE), como los modelos SIR y SEIRS para estimar los parámetros de este modelo discreto a partir de datos. Ilustramos el enfoque propuesto para los datos de las redes informáticas a partir de datos paramétricos. Más que eso, se modela con éxito, la Epidemia del SIDA en Cuba (1986-2000) y la Epidemia de la Peste bubónica en India (1908) desde nuestro enfoque. Este trabajo ayuda a graficar equivalencias entre dos modelos conceptualmente diferentes y destaca que dan resultados similares al tomar apropiadamente los valores de los parámetros.
Innovación social: construyendo las bases para un desarrollo comunitario sostenible. Caso Universidad Tecnológica de Panamá
Authors: Chang Jordán Ignacio Jacinto , Rodríguez George , Montes Héctor
Published: February 2023

La pandemia por la COVID-19 ha evidenciado la necesidad de un desarrollo sostenible de nuestro país e incrementado las desigualdades sociales, implicando que los gobiernos tengan un reto mayor por reducirla. Sin embargo, no solo hay que esperar que el gobierno de turno lo enfrente, sino que todos debemos colaborar en la solución de este problema. De esta manera, las universidades, mediante actividades de investigación y desarrollo también pueden aportar. Este trabajo presenta, de manera resumida, las acciones que ha estado realizando la Universidad Tecnológica de Panamá (U.T.P.) con miras a crear comunidades innovadoras mediante proyectos sostenibles en el tiempo, para el beneficio de sus ciudadanos. Aquí se comparten las características principales de propuestas, proyectos y los diferentes programas de desarrollo comunitario, con el fin de promocionar, divulgar y replicar las buenas prácticas con la premisa de la interacción del conocimiento de los estudiantes en la búsqueda de soluciones a los problemas de las comunidades
Planificación y gestión Ambiental de la cuenca del rio Changuinola
Authors: Ramos Pérez Jeffrey Gerardo
Published: February 2023

En la actualidad, unas de las dificultades que presenta el ambiente es el crecimiento continuo de las actividades antropogénicas, y sus efectos nos manifiestan un evidente riesgo de un grave deterioro ambiental, al que habrá que enfrentarse buscando los medios para mantener y desarrollar un enfoque equilibrado, elaborando planificaciones y gestionando políticas para un desarrollo sostenible. Por lo antes mencionado, se ha realizado una propuesta de planificación y gestión de los Recursos Naturales dentro del polígono de la cuenca del Rio Changuinola, y así diferenciar las áreas para una ordenación adecuada de los Recursos Naturales, ya que el desarrollo de actividades antropogénicas en zonas rurales modifica el espacio geográfico y origina una alteración del medio natural. La disminución de la cobertura boscosa y la degradación de los Recursos Naturales. Esta planificación se basa en una valoración de los Recursos Naturales que tiene la cuenca del Rio Changuinola, una de las principales de la provincia de Bocas del Toro. Esta investigación integró factores biofísicos de la cuenca. La metodología constó de recopilación de información, análisis del suelo actual y propuesta de una planificación y gestión ambiental. Entre los productos obtenidos, está la ubicación espacial de la información biofísica, el análisis de conflicto del uso de la tierra, las potencialidades que hay dentro del área a través de un análisis FODA, además una propuesta de iniciativa para el manejo del polígono de la cuenca. Se recomienda compartir la propuesta de planificación y gestión ambiental con los usuarios locales para contribuir al uso sostenible de los recursos dentro de la zona.
Entrevista al Ing. César Penailillo
Authors: Pinillo Armando
Published: February 2023

LG Electronics, es un fabricante líder de productos comerciales y de consumo que van desde televisores, electrodomésticos, soluciones de aire acondicionado, monitores, robots de servicio, componentes automotrices y sus marcas premium LG SIGNATURE y LG ThinQ inteligente son nombres familiares en todo el mundo.

    LG Electronics siempre a la vanguardia en tecnología, ya cuenta en Panamá con el Centro de Soluciones de Negocios para Latinoamérica. Esta unidad de Negocios de categoría mundial, está destinada a brindar servicios de capacitación y entrenamiento especializado en el rubro de HVAV; tanto de forma presencial, como en línea, para todos los países de Latinoamérica.

    El Ing. César Penailillo, vocero del Business Solutions Leader de LG Electronics, con más de 10 años experiencia trabajando en diferentes países con la empresa Trane, una de las marcas líderes de aires acondicionados de Estados Unidos y desde el 2019 forma parte del equipo de LG, nos hablará de los avances, expectativas y convenios para el nuevo Centro de Soluciones de Negocios para Latinoamérica.
Severo Ochoa de Albornoz
Authors: Araúz Jesús
Published: February 2023

Desde muy temprana edad, Severo Ochoa de Albornoz mostró interés por las ciencias naturales. Su empeño y el apoyo de sus profesores, lo llevaron a estudiar medicina en busca de la bioquímica. El buen desempeño académico, y la convivencia con personas destacadas, lo llevaron poco a poco a contribuir al desarrollo científico de las ciencias. Su notable producción científica, junto a las situaciones políticas de España, lo condujeron a tener vastas experiencias en el extranjero e, inclusive, nacionalizarse en EE. UU. Su trayectoria fue reconocida por muchos individuos y entidades alrededor del mundo, lo cual lo llevó a ganar un Premio Nobel y a ser un personaje influyente en varias ramas del conocimiento más allá de las ciencias naturales.
Efectividad de un programa breve para la reducción de estrés en personal de salud durante el contexto de la pandemia COVID-19: Un estudio piloto
Authors: Silva-Dominguez Daniel Sergio , Moreno-Valles Luisa , Huarancca-Berrocal Isabel , Manco-Avila Ermes , Torrejon-Fernandez Cynthia
Published: February 2023

Objetivo. Determinar la influencia de un programa breve de reducción del estrés en trabajadores de salud del Instituto Nacional Materno perinatal durante la pandemia COVID-19. Materiales y Métodos. Esta investigación corresponde a un estudio cuasi experimental, que consiste en la elaboración y aplicación de un programa breve de reducción del estrés en trabajadores del área de Puericultura del INMP. La población estuvo conformada por 45 trabajadores, 30 de ellas cumplieron con los criterios de inclusión para el estudio piloto, de las cuales se distribuyó, por conveniencia, una muestra de 15 participantes para el grupo experimental y 15 para el grupo control. Se aplicó la Escala de Depresión, ansiedad y estrés (Dass21) al inicio de la investigación y luego de concluir con el programa. Se realizó el análisis de frecuencias y porcentajes de la variable, análisis de ajuste de bondad a la curva normal, y pruebas T Student para muestras relacionadas (p<0.05) pre y post test intragrupo con un nivel de confianza al 95%. Resultados.  Se encontró diferencias significativas en el grupo experimental en sus medidas pre y post tratamiento respectivamente en las variables Estrés (T=5.20, p<0.001, D=0.742, Dif medias=3.00); Ansiedad (T=3.15, p<0.007, D=0.414, Dif medias=2.20) y Depresión (T=3.97, p<0.001, D=0.426, Dif medias=3.97) reduciéndose las medias de dichas variables post aplicación del programa piloto. Conclusión. El programa breve para la reducción del estrés es efectivo para la reducción del estrés, a su vez debido a que en sus sesiones se entrenaron estrategias cognitivas conductuales para la mejora de la salud mental, se redujo, de forma secundaria, indicadores de ansiedad y depresión presentes en la muestra.
Situación epidemiológica de la mortalidad materna en Colombia, 2022
Authors: Serna Trejos Juan Santiago , Lenis Gonzalez Juan Pablo
Published: February 2023

La mortalidad materna supone un problema de gran interés en salud pública, inicialmente propuesto dentro de los objetivos del nuevo milenio, donde se propuso lograr una reducción de este evento en 75 % en su tasa de ocurrencia1, según la Organización Mundial de la Salud (OMS) se estima que fallecen en promedio. Diariamente, alrededor de 830 mujeres por causas asociadas a su embarazo en curso, parto o postparto, Estas cifras se tornan más alarmantes en países de ingresos bajos y gran proporción de estas muertes, son de índole prevenible2. El número de muertes maternas se redujo en un 37% desde el año 2000. La tasa de mortalidad para el año 2015 en países en vía de desarrollo o de ingresos bajos fue de 239 por cada 100.000 nacidos vivos, a diferencias de países desarrollados donde se obtuvo tasas de 12 muertes por cada 100.000 nacidos vivos2.
Tamizaje auditivo neonatal: Guía para el diagnóstico temprano
Authors: Marin-Marín Diego Franco
Published: February 2023

La hipoacusia neurosensorial congénita es una de las patologías más frecuentes del recién nacido. Para realizar el diagnóstico y la detección temprana de dicha patología en la población pediátrica se requiere de exámenes audiológicos especializados como las emisiones otoacústicas y los potenciales evocados auditivos. Por ello, es importante tener una guía para identificar y detectar aquellos pacientes con sospecha de hipoacusia neurosensorial congénita.
Factores sociodemográficos en el riesgo de parto prematuro en gestantes del hospital Sergio Bernales en el período de 2019-2020
Authors: Chavez-Mauricio Ronni Delinger , Beltrán-Garate Brady Ernesto , Arango-Ochante Pedro
Published: February 2023

Objetivo. Determinar la relación de los factores sociodemográficos y el riesgo de parto prematuro en gestantes del hospital Sergio Bernales en el periodo de 2019-2020. Materiales y métodos. Estudio observacional, analítico, retrospectivo, y de casos-control, se buscará cuantificar la relación entre los factores sociodemográficos y el riesgo de parto prematuro. Se usará una revisión de historias clínicas correspondientes al servicio de Ginecología-Obstetricia del hospital Sergio Bernales. Los datos obtenidos se estudiarán mediante el programa SPSS y se buscará una asociación mediante análisis bivariado. Resultados. Del estudio de 300 gestantes, se realizó el análisis para 100 gestantes con diagnóstico de parto pretérmino que constituyeron los casos y 200 gestantes como grupo control. En el análisis bivariado se obtuvo que el parto pretérmino estuvo asociado a procedencia rural o extranjera (p<0.01); OR: 3.51 IC 95% = [ 2.03-6.06], edades extremas (p<0.01); OR: 2.72 con un IC 95% = [ 1.53-4.85], y no afiliada al SIS (p<0.03); OR: 2.59 con un IC 95% = [ 1.07-6.21]. Conclusiones. La procedencia rural o extranjera, edades extremas y no afiliada al SIS son factores asociados al riesgo de parto pretérmino.
Karanlık Sular Filminin Kozmik ve Fantastik Yapısında Kant'ın Yüce Kavramının İzini Sürmek
Authors: OSMANOĞULLARI Fırat
Published: February 2023

Bu çalışmada ilk olarak, Türk korku sinemasında oldukça sıra dışı bir yer işgal eden, Kutluğ Ataman’ın Karanlık Sular (1993) filminin yapısı, korku edebiyatının en önemli isimlerinden birisi olan H.P. Lovecraft’ın ‘kozmik korku’ kavramından ve filozof Tzvetan Todorov’un ‘fantastik’ yaklaşımından yola çıkarak ortaya konmaya çalışılacaktır. Ardından, filmin kozmik ve fantastik yapısını oluşturan ve çoğunlukla maddi ve doğaüstü unsurların film boyunca çatışmasından doğan korku, acı ve dehşet verici olaylar, imajlar ve ses blokları, Immanuel Kant’ın ‘yüce’ kavramı üzerinden analiz edilecek, bu filmsel unsurların hangi nitelikleri bakımından seyircide yüce hissini yaratabilme kabiliyetine sahip olduğu tartışılacaktır.
AFET ODAKLI RİSK İLETİŞİMİNDE SOSYAL MEDYA KULLANIMI: AFAD ÖRNEĞİ
Authors: AĞCA Mahmut Enes
Published: February 2023

Doğal olaylar ya da insan kaynaklı faaliyetler sonucu istenmeyen durumların oluşma olasılığı olarak nitelendirilebilecek risk kavramı gündelik yaşantıda pek çok farklı alanda kendini göstermektedir. Hem toplumsal yaşantıda hem de kurumsal düzlemde çeşitli riskler hergün oluşmakta ve bu risklerin kimileri gerçekleşmektedir. Risk durumlarının gerçekleşmesi halinde durumun krize dönüşmesi olasıdır. Doğal olaylar temelinde değerlendirildiğinde riskli durumların gerçekleşmesi söz konusu olduğunda durumun afete dönüşmemesi için risk iletişimi önemli bir rol üstlenmektedir. Bu çalışmada, ana amacı hedef kitlelerde farkındalık oluşturmak olan risk iletişimi, afet riski iletişimi özelinde değerlendirilmiştir Bu doğrultuda, Türkiye’de afet riskine yönelik iletişim konusunda sorumlu kuruluş T.C. İçişleri Bakanlığı Afet ve Acil Durum Yönetimi Başkanlığı’nın (AFAD) sosyal medyadaki varlıklarının risk iletişimi doğrultusunda kullanılıp kullanılmadığını ortaya koymaktır. AFAD’ın sosyal medya paylaşımları 1 yıl süreyle içerik analizine tabi tutulmuştur. Bu kapsamda, 1 Nisan 2021 - 1 Nisan 2022 tarihleri arasında AFAD’ın en yüksek takipçi sayısına sahip üç sosyal media varlığı örneklem alınmıştır. Çalışmada, AFAD’ın Facebook, Instagram ve Twitter hesapları üzerinden gerçekleştirilen sosyal medyayı risk iletişimi bağlamında kullanıp kullanmadığı, kullanılıyorsa hangi afet türleri ekseninde nasıl bir mesaj tasarımıyla risk iletişimi yürüttüğüne ilişkin bulgular elde edilmesi amaçlanmıştır. Araştırmada, AFAD’ın sosyal medya hesaplarında etkin risk iletişiminin varlığı saptanmış ve paydaşların risklere ilişkin sürekli bilgilendirme yaptığı ancak katılımcılık ve kamu katılımı yönünden yetersiz olduğu sonucuna ulaşılmıştır.
Voluntary Urinary Retention Effects on Cognitive Performance
Authors: Griswold Cheryl A. , Vento Kaila A. , Blacker Kara J.
Published: February 2023

INTRODUCTION: Aircrew in-flight bladder relief remains an understudied stressor; specifically the effects of withholding urination on flight-relevant cognitive performance. This quasi-experimental study investigated whether voluntary urinary retention over a 3-h period negatively
impacted cognitive performance.METHODS: We assessed vigilance using the psychomotor vigilance task (PVT) and measured the P3b event-related potential (ERP) in response to PVT stimuli. We also measured working memory (WM) performance using a change detection task and assessed the
contralateral delay activity during the WM task using electroencephalography (EEG). Subjects (N = 29) completed a baseline test on both tasks, following bladder voiding and immediately after consuming 0.75 L of water. Subjects performed tasks at 1, 2, and 3 h post-void and urgency to
void one’s bladder was assessed regularly. A total of 17 subjects were able to complete the entire study protocol. Repeated-measures ANOVAs assessed changes in PVT and WM outcomes.RESULTS: Reaction time (RT) on the PVT was significantly impaired (5% slower) with longer urinary
retention time and showed a 2.5-fold increase in the number of lapses (RT > 500 ms) with increased retention time. Together these results indicate that sustained attention was impaired with increased voluntary urine retention. We did not see significant changes in WM performance with our
manipulations. Additionally, neural measures acquired with EEG for both tasks did not show any significant effect.DISCUSSION: As measured with the PVT, sustained attention was impaired during 3 h of voluntary urinary retention, highlighting the need for further development of adequate
bladder relief systems in military aviation.Griswold CA, Vento KA, Blacker KJ. Voluntary urinary retention effects on cognitive performance. Aerosp Med Hum Perform. 2023; 94(2):79–85.
A Comparison Between Three Computer-Based Cone Specific Color Vision Tests
Authors: Lovell Julie , Rabin Jeff
Published: February 2023

INTRODUCTION: Computerized color contrast sensitivity (CS) tests that aim to determine presence, type, and severity of color vision deficiency have been developed and are available, but data on agreement between tests is lacking. The purpose of the present study was to determine
data agreement between three computerized color vision tests.METHODS: A total of 50 subjects, 25 color vision normal (CVN) and 25 color vision deficient (CVD), were tested with the Konan CCT-HD®, NCI, and a modified version of the Innova CCT. Sensitivity and specificity
were compared across systems as well as differences in log CS values and how these relate to standards used to classify occupational performance.RESULTS: Each test showed 100% sensitivity for detection of hereditary red-green CVDs as well as type (protan vs. deutan). Each test showed
100% specificity for confirming normal red-green color vision in CVNs. Innova CCT and NCI showed 100% specificity in CVNs and CVDs for S cone CS. Konan CCT-HD® showed 96% specificity in CVNs and 92% in CVDs for S cone CS.DISCUSSION: These findings indicate that each
test reliably identifies hereditary CVD and confirms normal color vision. However, the three tests differ slightly in log CS values used to determine pass/fail scores of red-green color vision using a 100-point scale, and all show that protans consistently score lower than deutans on cone
CS. Hence, depending on the criterion used in occupational settings, a single score may not prove equitable for individuals who have a protan deficiency.Lovell J, Rabin J. A comparison between three computer-based cone specific color vision tests. Aerosp Med Hum Perform. 2023;
94(2):54–58.
Marantic Endocarditis and Lung Adenocarcinoma with Brain Metastasis: A Diagnostic Conundrum
Authors: Brunda M.S. , Mohan Arushi , Patil Anant , Indi Supriya , Doraiswamy Prakash , Chowdhary Rishi
Published: February 2023

Neurological symptoms such as headache and blurring of vision could be a manifestation of an underlying lung adenocarcinoma. The objective of this case report is to unveil the possible differentials and processes involved in the diagnosis of marantic endocarditis. A 57-year old male with blurring of vision and brain CT revealing multiple abscesses, sterile on culture, was treated as per guidelines. However, the patient had recurrent complaints that reinforced recurrent admissions and the patient was found to be COVID-19 positive during the pandemic when a routine test was performed in the emergency department. Suspicious lesions on the chest X-ray were further scrutinised and the patient was diagnosed with lung adenocarcinoma. To further investigate the sterile cultures in the brain, a cardiologist’s opinion was taken and a transthoracic echocardiogram was done, which was unremarkable. The increased suspicion for non-infective endocarditis necessitated a transoesophageal echocardiogram, which was positive for vegetations on the aortic valve. The patient was treated with anticoagulants and chemotherapy. In conclusion, in patients with CT findings of abscesses and sterile cultures, it is crucial to investigate the possible differentials in a meticulous fashion, as there could be an undiagnosed lung cancer in a non-smoker and there is a rare possibility of a sterile vegetation on the aortic valve, as was seen in the authors’ case.
The Affecting Factors of Willingness to Communicate of Inside Classroom, Outside Classroom, and Digital Setting on Japanese Language Students
Authors: Muliadi Muliadi
Published: February 2023

The present study investigates the variables believed to relate to and affect Japanese language students’ willingness to communicate in Japanese in online learning situations. This study was a quantitative study that used questionnaire data as the main data distributed through the Google Form platform. A total of 81 Japanese language students from three universities participated. The findings showed that anxiety negatively correlated with willingness to communicate inside the classroom. Meanwhile, self-rating and virtual intercultural experiences positively correlated with willingness to communicate inside the classroom, outside the classroom, and in digital settings. The regression analysis showed that language anxiety, self-rating, and virtual intercultural experiences variables had a minor effect on willingness to communicate inside the classroom (19%) and digital setting (22.5 %). The results of this study indicate that besides the factors of anxiety, self-rating, and virtual intercultural experience, other variables are considered to be more contributing to how Japanese language students have the will to communicate in the target language.
Directive Illocutionary Act Produce by the Characters in Cruella Movie
Authors: Febriola Ni Kadek Nia , Maharani Putu Devi , Putri I Gusti Ayu Vina Widiadnya
Published: February 2023

AbstractThis study aims to determine the types of the directive act and its function found in the American Disney movie Cruella, released in 2021. The study was conducted with the observation method and analyzed using quantitative and qualitative methods. The researcher collected the data through several steps, such as watching the movie several times, taking note of the utterance indicated as a directive act, and classifying the utterance into the types of the directive. The theory proposed by Searle (1979) was applied to analyze the data. Therefore, this study found that 51 utterances were considered directive acts. The data is divided into five types, including ask (16), suggest (10), forbid (7), order (9), and request (3). From the total data, asking became the most frequent frequency in the movie since the character frequently used the question to get the hearer to give an answer or the information. The occurrence of suggestions on the second rank of total data found follows it. The speaker produces the type of suggestion to suggest the hearer do an action. AbstrakTindak Ilokusi Directif yang Diucapkan oleh Tokoh pada Film Cruella Tujuan dari penelitian ini adalah untuk menemukan tipe tindak ilokusi direktif dan fungsinya pada film produksi Disney, Amerika yang berjudul Cruella yang tayang di tahun 2021. Penelitian ini dilakukan dengan metode observasi dan dianalisis menggunakan metode kuantitatif dan kualitatif. Peneliti mengumpulkan data melalui berbagai tahapan, seperti menonton film Cruella beberapa kali, mencatat ucapan yang terindikasi sebagai tindak ilokusi direktif, dan mengklasifikasikan ucapan tersebut kedalam tipe-tipe tindak ilokusi direktif. Teori yang dicetuskan oleh Searle (1979) diaplikasikan untuk menganalisis data. Dengan demikian, hasil penelitian menunjukan terdapat 51 ujaran yang dianggap sebagai tindak tutur direktif. Data dibagi menjadi lima tipe yaitu pertanyaan (16), saran (10), larangan (7), perintah (9), permintaan (3). Dari total data, tipe pertanyaan menjadi tipe yang paling sering muncul di film karena tokoh pada film sering menggunakan pertanyaan untuk membuat pendengar memberikan jawaban atau informasi. Jumlah tipe pertanyaan diikuti oleh penggunaan dari tipe saran yang berada pada posisi kedua sebagai tipe yang paling sering muncul dari total data. Pembicara menyampaikan sesuatu dengan saran untuk menyarankan pendengar dalam melakukan sesuatu.
Transient Simulation of an Air-source Heat Pump under Cycling of Frosting and Reverse-cycle Defrosting
Authors: Ma Jiacheng , Kim Donghun , Braun James E.
Published: February 2023

Frost accumulation is a common but undesired phenomenon for air-source heat pump (ASHP) systems in winter operations. Reverse-cycle defrosting that applies heat to the outdoor coil by reversing the thermodynamic cycle, is one of the predominant means for periodic removal of the accumulated frost. This paper presents a dynamic modeling framework for ASHPs under cycling of frosting and reverse-cycle defrosting operations. A uniform model structure was applied to frost formation and melting models, which were incorporated into the evaporator model, without a need for reinitializing the system when the operating mode switches between heating and defrosting. The developed model was simulated to predict transients of a residential ASHP under multiple cycles of frosting and defrosting operations, and results yielded good agreement with measurements.
Multifrequency dielectric mapping of fixed mice colon tissues in cell culture media via scanning electrochemical microscopy
Authors: Vyas Varun , Kotla Niranjan G. , Rochev Yury , Poudel Anup , Biggs Manus
Published: February 2023

Alternating current scanning electrochemical microscopy (AC-SECM) is a powerful tool for characterizing the electrochemical reactivity of surfaces. Here, perturbation in the sample is induced by the alternating current and altered local potential is measured by the SECM probe. This technique has been used to investigate many exotic a range of biological interfaces including live cells and tissues, as well as the corrosive degradation of various metallic surfaces, etc. In principle, AC-SECM imaging is derived from electrochemical impedance spectroscopy (EIS) which has been used for a century to describe interfacial and diffusive behaviour of molecules in solution or on a surface. Increasingly bioimpedance centric medical devices have become an important tool to detect evolution of tissue biochemistry. Predictive implications of measuring electrochemical changes within a tissue is one of the core concepts in developing minimally invasive and smart medical devices. In this study, cross sections of mice colon tissue were used for AC-SECM imaging. A 10 micron sized platinum probe was used for two-dimensional (2D) tan δ mapping of histological sections at a frequency of 10 kHz, Thereafter, multifrequency scans were performed at 100 Hz, 10 kHz, 300 kHz, and 900 kHz. Loss tangent (tan δ) mapping of mice colon revealed microscale regions within a tissue possessing a discrete tan δ signature. This tan δ map may be an immediate measure of physiological conditions in biological tissues. Multifrequency scans highlight subtle changes in protein or lipid composition as a function of frequency which was recorded as loss tangent maps. Impedance profile at different frequencies could also be used to identify optimal contrast for imaging and extracting the electrochemical signature specific for a tissue and its electrolyte.
Determinants of arterial elastic function in middle-aged and elderly people: A population-based cross-sectional study from a low-income population in China
Authors: Sun Jiayi , Zhang Zhen , Fei Yunhan , Gao Yannan , Li Zejian , Gao Shuai , Wang Yunfan , Liu Jie , Tu Jun , Wang Haiying , Wang Jinghua , Ning Xianjia , Zhao Wenjuan , Zhang Wenjuan
Published: February 2023

Background

Arterial stiffness is closely associated with the occurrence of many cardiovascular and cerebrovascular diseases. However, the risk factors and mechanisms related to arterial stiffness development have only been partially elucidated. We aimed to describe arterial elastic function and its influencing factors in middle-aged and elderly people in rural China.

Methods

This was a cross-sectional study conducted among residents, aged ≥45 years, of Tianjin, China, between April and July 2015. Data regarding participant demographics, medical history, lifestyle, and physical examination results were collected and assessed the association with arterial elastic function using linear regression.

Results

Of the 3,519 participants, 1,457 were male (41.4%). Brachial artery distensibility (BAD) decreased by 0.5%/mmHg with every 10-year increment in age. The mean BAD value was 0.864%/mmHg lower in women than in men. With each unit increase in mean arterial pressure, the BAD decreased by 0.042%/mmHg. In patients with hypertension or diabetes, the BAD decreased by 0.726 and 0.183%/mmHg, respectively, compared with those without hypertension or diabetes. For each unit increase in triglyceride (TG) level, the mean BAD increased by 0.043%/mmHg. With each increase in body mass index (BMI) category, the BAD increased by 0.113%/mmHg. Brachial artery compliance (BAC) decreased by 0.007 ml/mmHg with each 10-year increase in age, and brachial artery resistance (BAR) increased by 30.237 dyn s–1 cm–5. The mean BAC in women was 0.036 ml/mmHg lower and the mean BAR was 155.231 dyn s–1 cm–5 higher in women than in men. In individuals with hypertension, the mean BAC decreased by 0.009 ml/mmHg and the mean BAR increased by 26.169 dyn s–1 cm–5. With each increase in BMI category, the mean BAC increased by 0.005 ml/mmHg and the mean BAR decreased by 31.345 dyn s–1 cm–5. For each unit increase in TG level, the mean BAC increased by 0.001 ml/mmHg.

Conclusion

These findings indicate that age, sex, mean arterial pressure, BMI, diabetes, hypertension, and TG level are independently associated with the components of peripheral arterial elasticity. Understanding the factors influencing arterial stiffness is important for developing interventions to minimize arterial aging and cardiovascular and cerebrovascular diseases caused by arterial aging.
Virtual reality exposure therapy for reducing social anxiety in stuttering: A randomized controlled pilot trial
Authors: Chard Ian , Van Zalk Nejra , Picinali Lorenzo
Published: February 2023

We report on findings from the first randomized controlled pilot trial of virtual reality exposure therapy (VRET) developed specifically for reducing social anxiety associated with stuttering. People who stutter with heightened social anxiety were recruited from online adverts and randomly allocated to receive VRET (n = 13) or be put on a waitlist (n = 12). Treatment was delivered remotely using a smartphone-based VR headset. It consisted of three weekly sessions, each comprising both performative and interactive exposure exercises, and was guided by a virtual therapist. Multilevel model analyses failed to demonstrate the effectiveness of VRET at reducing social anxiety between pre- and post-treatment. We found similar results for fear of negative evaluation, negative thoughts associated with stuttering, and stuttering characteristics. However, VRET was associated with reduced social anxiety between post-treatment and one-month follow-up. These pilot findings suggest that our current VRET protocol may not be effective at reducing social anxiety amongst people who stutter, though might be capable of supporting longer-term change. Future VRET protocols targeting stuttering-related social anxiety should be explored with larger samples. The results from this pilot trial provide a solid basis for further design improvements and for future research to explore appropriate techniques for widening access to social anxiety treatments in stuttering.
Terminal Ediacaran microbialite lithofacies associations with paleo-environmental constraints in a high-frequency sequence stratigraphic framework of Sichuan Basin, SW China
Authors: Zhou Yuanquan , Li Zhong
Published: February 2023

The terminal Ediacaran shallow marine microbialites are significant for paleo-environment reconstruction and petroleum exploration. Their depositional and paleo-environmental characteristics during high-frequency sea-level fluctuations were paid less attention, which limited the understanding of their evolution and related reservoir characterization. Microbialites from the fourth member of the upper Ediacaran Dengying Formation, Gaoshiti-Moxi area, Sichuan Basin, SW China are important records for studying their lithofacies associations and paleo-environmental constraints in high-frequency depositional sequences. Petrographic and geochemical analyses (in-situ major and trace elements and carbon and oxygen isotopes) indicate microbialites depositional and paleo-environmental evolution on a rimmed platform within a fourth-order depositional sequence. From late TST (transgressive systems tract) to early HST (highstand systems tract), thick-bedded dark-grey dolomudstone-thin-bedded spotted thrombolite dominates the platform margin; while thick-bedded dark-grey dolomudstone-thin bedded dark-grey wavy stromatolite dominates the platform interior. From late HST to early TST of the next fourth-order sequence, the platform margin is dominated by thick-bedded spotted thrombolite—dolograinstone, while the carbonate interior is dominated by thin-medium-bedded layered thrombolite—light-grey wavy stromatolite. Salinity correlates well with microbialite lithofacies associations: the platform interior layered thrombolite and wavy stromatolite enriched lithofacies associations are characterized by higher salinity than that of the platform margin spotted thrombolite enriched lithofacies associations. The microbialite lithofacies associations are less constrained by redox: platform interior layered thrombolite and wavy stromatolite enriched lithofacies associations are slightly more reduced than the platform interior spotted thrombolite enriched lithofacies associations. The redox analysis of the microbialites also indicates low oxygen levels of shallow marine in the study area during terminal Ediacaran, with possible oxygenation at the Ediacaran-Cambrian boundary. The study suggests that the terminal Ediacaran microbialite development was controlled by both high-frequency sea-level fluctuations and paleo-environmental factors such as salinity and redox. Platform margin spotted thrombolitic reefs from late fourth-order HST to next early fourth-order TST serve as favorable microbialite reservoirs. Platform interior layered thrombolites and wavy stromatolites are regarded as potential reservoirs, which deserve more detailed depositional-paleo-environmental research.
Inclusion in the heat of the moment: Balancing participation and mastery
Authors: Øen Kristian , Krumsvik Rune Johan , Skaar Øystein Olav
Published: February 2023

Individual and social explanatory models provide different frameworks for teachers’ practice. This study addresses how teachers’ understanding of inclusion and challenging behaviors affects their work with an inclusive practice in school. The chosen research design can be characterized as a qualitatively driven mixed-method case design, and the data collection was based on an explorative sequential design. All teachers from two schools that both have a vision linked to being inclusive were invited to participate, and the first five teachers who signed up from each school were included in this study. The data are based on interviews with and observations of 10 teachers as well as a survey conducted at 16 schools in Western Norway distributed across eight different municipalities. Based on an inductive analysis, the findings show that physical participation in the classroom is central to teachers’ understanding of inclusion. At the same time, they emphasize the importance of social and academic mastery. The study, nevertheless, shows that classroom participation and coping can conflict with each other. This means that teachers must often balance different considerations related to both practical and ethical dilemmas. When they encounter challenging behavior, they are additionally forced to make assessments in stressful situations. It is also in these situations that the underlying and often unconscious explanatory models provide the greatest guidance for the teachers’ decisions. Nevertheless, decision-making in stressful situations seems to be an almost absent topic in both teacher training and the professional community in schools. The authors of this article, therefore, argue that decision-making in stressful situations seems to be underestimated in the work on developing inclusive practices.
Factors affecting the utilization of solar energy: An approach to sustainable rural development in Iran
Authors: Hatamifard Sevil , Farajallah Hosseini Seyed Jamal , Mirdamadi Seyed mehdi
Published: February 2023

This study was conducted to investigate the role of factors affecting the utilization of solar energy for the sustainable rural development of Zanjan Province. The statistical population in this study was rural households who used solar energy technology in Zanjan Province, and 210 households were selected as a sample using Kerjesi & Morgan’s table. The data collection tool was a questionnaire. The face and content validity of the questionnaire was confirmed by a panel of experts before the pre-test. The reliability of the research tool was also confirmed by conducting a pre-test among thirty people other than the statistical sample and calculating Cronbach’s alpha for the main scales of the questionnaire (in the range of 0.72–0.90). Data were analyzed using SPSS24 and AMOS22. The data were analyzed using structural equation modeling. The results showed a positive and significant relationship between educational, socio-cultural, policymaking, and environmental factors and the utilization of solar energy, and these variables explained 37% of the variance of the dependent variable. However, a weak significant relationship was observed between economic and technical factors with the utilization of solar energy. The finding of this study has some meaningful policy implications. The energy costs, sunlight coverage, and the efficiency of solar energy systems have caused solar energy to be considered as a suitable alternative for providing electricity and heating in rural areas of Iran.
Can energy conservation and emission reduction policies affect household carbon emissions? Evidence from China
Authors: Luo Juan , Yang Jiwen , Wan Siyu , Zhao Jiaqi , Liang Jing
Published: February 2023

This article investigates the impact of energy conservation and emission reduction policies on household carbon emissions by using the fixed-effect model and finds energy conservation and emission reduction policy has a positive effect on household carbon emissions. The data sample covers 31 provinces, autonomous regions and municipalities in China from 2011 to 2020. In addition, this article conducts a mechanism test and finds new energy public buses can play a negative mediating effect on the relationship between government policy and household carbon emissions. Besides, this article finds that the effect of energy conservation on emission reduction policies is more evident in western areas.
Screening and mutation analysis of phenylalanine hydroxylase deficiency in newborns from Jiangxi province
Authors: Zeng Baitao , Lu Qing , Chen Shaohong , Guan Huizhen , Xu Xiaolan , Zou Yongyi , Wang Feng , Huang Shuhui , Liu Yanqiu , Yang Bicheng
Published: February 2023

Background: Phenylalanine hydroxylase deficiency (PAHD) is an autosomal recessive disorder of amino acid metabolism and caused by mutations in the phenylalanine hydroxylase (PAH) gene. Without timely and appropriate dietary management, the disturbance of amino acid metabolism may impair cognitive development and neurophysiological function. Newborn screening (NBS) can aid the early diagnosis of PAHD, which can give accurate therapy to PAHD patients in time. In China, the PAHD incidence and PAH mutation spectrum vary enormously across the provinces. A total of 5,541,627 newborns from Jiangxi province were screened by NBS between 1997 and 2021.

Method: One seventy one newborns from Jiangxi province were diagnosed with PAHD. By Sanger sequencing and the multiplex ligation-dependent probe amplification (MLPA) analysis, mutation analysis was performed in 123 PAHD patients. Using an arbitrary values (AV)-based model, we compared the observed phenotype with the predicted phenotype based on the genotype.

Results: In this study, we speculated the PAHD incidence of Jiangxi province was about 30.9 per 1,000,000 live births (171/5,541,627). We summarized the PAH mutation spectrum in Jiangxi province for the first time. Two novel variants (c.433G > C, c.706 + 2T > A) were found. The most prevalent variant was c.728G > A (14.1%). The overall prediction rate of the genotype-phenotype was 77.4%.

Conclusion: This mutation spectrum is very meaningful to improve the diagnostic rate of PAHD and to increase the accuracy genetic counseling. This study offers data for the genotype-phenotype prediction suitable for Chinese population.
A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma
Authors: Yang Yizhou , Cai Zeman , Huang Kaichun , Li Mei , Wang Xiao , Lin Yinbing , Chen Sijie , Yang Zhining , Lin Zhixiong
Published: February 2023

Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N6-methyladenosine (m6A) methylation had a significant impact on the tumor immune microenvironment (TIME) and immunotherapy of head and neck squamous cell carcinoma. Thus, combining indicated that immune-related gene prognostic index with m6A status should offer a better predictive power for immune responses.

Methods: Head and neck squamous cell carcinoma samples from the cancer genome atlas (TCGA, n = 498) and gene expression omnibus database (GSE65858, n = 270) were used in this study. Cox regression analysis was used to construct the indicated that immune-related gene prognostic index through immune-related hub genes which were identified by weighted gene co-expression network analysis (WGCNA). The m6A risk score was constructed by least absolute shrinkage and selection operator (LASSO) regression analysis. Principal component analysis was used to construct a composite score, and systematically correlate subgroups according to tumor immune microenvironment cell-infiltrating characteristics.

Results: A composite score was determined based on indicated that immune-related gene prognostic index and m6A risk score. Head and neck squamous cell carcinoma patients in the cancer genome atlas were divided into four subgroups: A (IRGPI-High&m6A-risk-High, n = 127), B (IRGPI-High&m6A-risk-Low, n = 99), C (IRGPI-Low&m6A-risk-High, n = 99), and D (IRGPI-Low&m6A-risk-Low, n = 128), and overall survival (OS) was significantly different between subgroups (p < 0.001). The characteristics of tumor immune microenvironment cell infiltration in the four subgroups were significantly different in subgroups (p < 0.05). The receiver operating characteristic (ROC) curves show the predictive value of composite score for overall survival was superior to other scores.

Conclusion: The composite score is a promising prognostic signature which might distinguish immune and molecular characteristics, predict prognosis, and guide more effective immunotherapeutic strategies for head and neck squamous cell carcinoma.
Predicting lncRNA-protein interactions with bipartite graph embedding and deep graph neural networks
Authors: Ma Yuzhou , Zhang Han , Jin Chen , Kang Chuanze
Published: February 2023

Background: Long non-coding RNAs (lncRNAs) play crucial roles in numerous biological processes. Investigation of the lncRNA-protein interaction contributes to discovering the undetected molecular functions of lncRNAs. In recent years, increasingly computational approaches have substituted the traditional time-consuming experiments utilized to crack the possible unknown associations. However, significant explorations of the heterogeneity in association prediction between lncRNA and protein are inadequate. It remains challenging to integrate the heterogeneity of lncRNA-protein interactions with graph neural network algorithms.

Methods: In this paper, we constructed a deep architecture based on GNN called BiHo-GNN, which is the first to integrate the properties of homogeneous with heterogeneous networks through bipartite graph embedding. Different from previous research, BiHo-GNN can capture the mechanism of molecular association by the data encoder of heterogeneous networks. Meanwhile, we design the process of mutual optimization between homogeneous and heterogeneous networks, which can promote the robustness of BiHo-GNN.

Results: We collected four datasets for predicting lncRNA-protein interaction and compared the performance of current prediction models on benchmarking dataset. In comparison with the performance of other models, BiHo-GNN outperforms existing bipartite graph-based methods.

Conclusion: Our BiHo-GNN integrates the bipartite graph with homogeneous graph networks. Based on this model structure, the lncRNA-protein interactions and potential associations can be predicted and discovered accurately.