bluuebunny/crossref_metadata_2025 huggingface dataset:
Knockdown of EDA2R alleviates hyperoxia-induced lung epithelial cell injury by inhibiting NF-κB pathway
Authors: Jia Nan , Jia Yi , Yang Fen , Du Wenchao
Published: September 2022

Background: Long-term hyperoxia impairs growth of the lungs and contributes to development of bronchopulmonary dysplasia. Ectodysplasin A (EDA) binds to ectodysplasin A2 receptor (EDA2R) and is essential for normal prenatal development. The functioning of EDA2R in bronchopulmonary dysplasia is investigated in this study.
Methods: Murine lung epithelial cells (MLE-12) were exposed to hyperoxia to induce cell injury. Cell viability and apoptosis were detected, respectively, by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay and flow cytometry. Inflammation and oxidative stress were evaluated by enzyme-linked immunosorbent serologic assay.
Results: Hyperoxia decreased cell viability and promoted cell apoptosis of MLE-12. EDA2R was elevated in hyperoxia-induced MLE-12. Silencing of EDA2R enhanced cell viability and reduced cell apoptosis of hyperoxia-induced MLE-12. Hyperoxia-induced up-regulation of tumor necrosis factor alpha (TNF-α), Interleukin (IL)-1β, and IL-18 as well as MLE-12 was suppressed by knockdown of EDA2R. Inhibition of EDA2R down-regulated the level of malondialdehyde (MDA), up-regulated superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in hyperoxia-induced MLE-12. Interference of EDA2R attenuated hyperoxia-induced increase in p-p65 in MLE-12.
Conclusion: Knockdown of EDA2R exerted anti-inflammatory and antioxidant effects against hyperoxia-induced injury in lung epithelial cells through inhibition of nuclear factor kappa B (NF-κB) pathway.
Settlement and long-term bearing capacity of the pile taking into account the rheological properties of soils
Authors: Ter-Martirosyan Z. G , Ter-Martirosyan A. Z , Ermoshina L. Yu
Published: September 2022

A large number of scientific works by both Russian and foreign authors are devoted to the interaction of a single pile with the surrounding and underlying soils. Based on experimental, numerical and theoretical studies, various methods, approaches and solutions have been obtained in scientific works, which make it possible to most correctly predict the settlement and bearing capacity of a single pile. Research in this area is relevant, since the determination of the settlement of the pile, as well as the study of the mechanism of distribution of the load transmitted to it, play an important role in the design of pile foundations. In this work, the boundary value problem of the interaction of a long and incompressible pile with the surrounding and underlying soils in an elastic-viscous formulation, taking into account soil strengthening, was solved, based on the Maxwell model, as well as on the basis of the rheological model of A.Z. Ter-Martirosyan. This study presents a detailed course of solving the boundary value problem, as well as the basic formulas for calculating the settlement and long-term bearing capacity of a single pile. The change in the curve of dependence σ R ( t ) at different values of soil viscosity is shown when solving the problem in an elastic-viscous formulation. An additional graph of σ R ( t ) dependence is presented showing the difference in the presented soil models. Based on the plotted graphs of the dependence of σ R ( t ) when solving the problem in an elastic-viscous formulation, it can be concluded that the time to reach the maximum value of the load under the foot of the pile is directly proportional to the value of the soil viscosity. When solving the problem on the basis of the rheological model A.Z. Ter-Martirosyan, the maximum value of the load under the foot of the pile is reached earlier than when solving the problem in an elastic-viscous formulation both with and without soil strengthening, which requires additional study.
Comparative experiment to determine the waterproofness of concrete by "wet spot" and "breathability" methods
Authors: Vankova N. R , Fomina A. E
Published: September 2022

Comparative tests of control samples of concrete for water resistance by the direct method of "wet spot" and the method of "air permeability" were carried out. Tests of 6 series of control samples showed that 60 % of the results obtained by the two methods differ by 0.2 MPa (one brand of water resistance W), which is unacceptable. The range of results for the direct "wet spot" method was 0.6 MPa (four waterproof grade W), more than for the "air permeability" method 0.4 MPa (three grade W). Probably, this is due to the imperfection of test methods, with an insufficient level or lack of metrological confirmation of equipment for determining water resistance, and more. In production practice, this situation means that the test results obtained are not provided with confidence, and as a result, under these conditions, it is possible to produce products (concrete) that do not meet regulatory requirements.
POSSIBILITY OF APPLICATION OF О. SHASHENKO’S CRITERION TO THE FORECAST OF STRENGTH OF SANDY LOAM SOILS
Authors: SHAPOVAL V. G. , IVANOVA G. P. , ZHYLINSKA S. R. , PASHCHENKO O. А.
Published: September 2022

Purpose. Experimental dependences "destructive tangential stress – vertical load" has the form of a curvilinear line, which is sometimes called the Coulomb – Mohr envelope. In this case, the Coulomb – Mohr strength criterion gives a value of the destructive tangential stress other than zero, which, in turn, leads to an overestimation of the holding forces when calculating the stability and strength of soil foundations and structures. The analysis showed that the problem of considering physical nonlinearity of the strength properties of clay soils is relevant, and one of the ways to solve it is to use the well-known in the mechanics of soil strength O. Shashenko’s criterion. The purpose of the scientific article is the following – according to the known experimental results of consolidated – drained tests of sandy loam soil in the device of single-plane shear, it is necessary: to perform approximation of experimental data using linear dependence (Coulomb – Mohr strength criterion) and nonlinear dependence (O. Shashenko’s strength criterion); to estimate the accuracy of the approximation using the relative standard error and to extrapolate the approximation results to the region of low pressures. Methodology. According to the relevant recommendations, the properties of soils and their classification were determined. Also, according to the recommendations, the strength of the soil at its natural moisture and when water-saturated were determined. The obtained results are presented in tabular form. Material constants that are included in the Coulomb – Mohr and O. Shashenko’s criteria were determined. The conformity of the strength criteria to the experimental data was evaluated, and extrapolation of these criteria in the field of low pressures was performed. Results. In the field of change of experimental data, the dependence "destructive load – vertical pressure on the soil", established within O. Shashenko’s criterion of strength, has a better fit of the experiment than a similar dependence on the criterion of Coulomb – Mohr. The criterion of soil strength proposed by O. Shashenko can be used to predict the strength of sandy soils. Scientific novelty. Approximation of experimental results of consolidated-drained tests of sandy soil in the device of single-plane shear using the strength criteria of Coulomb – Mohr and O. Shashenko is performed. Practical value. A comparative analysis of the results is carried out and the use of O. Shashenko’s strength criterion for forecasting the strength of sandy soils is substantiated.
THE CONCEPT OF FORMING AND DEVELOPING HUMANITARIAN HUBS IN UKRAINE DURING MILITARY AGGRESSION
Authors: OKOROKOV A. , VERNYHORA R. , OKOROKOVA Y. , CHERNOVA O.
Published: September 2022

Purpose. The aim of the work is to analyze the current state of the humanitarian situation in Ukraine in the context of military aggression and develop ways to improve this situation by creating new and developing existing transport hubs, which are located both on the western border of the state and in central regions. Methodology. In the course of the study, methods of analysis and synthesis were used to study the available information regarding the current state and trends in the further development of logistics and humanitarian hubs both on the western border and in the middle of the country. Aggregation and intelligent analysis of information to determine promising directions for the development of the logistics network. Results. The uncertain situation that has developed in the work of seaports stimulates the state to search for alternative ways of exporting and importing raw materials and finished products. To address this issue, it is also advisable to develop a network of transport hubs near the western border. At the moment, 31 regional humanitarian aid hubs have been created in Ukraine, the leaders in terms of the number of hubs are the Zaporozhye region - 5 hubs, as well as Kyiv and Ivano-Frankivsk regions - 2 hubs each. The rest of the regions have 1 hub each. The number of hubs in the border areas remains insufficient, especially given the sharp change in the directions of the main cargo flows - grain cargo and metal. In particular, as of March 2022, the average daily need for transportation in the direction of the EU reaches 8,000 wagons per day, therefore, it is urgent to address the issue of developing both the existing system for replacing wagon bogies and creating additional transshipment infrastructure. Scientific novelty. The authors have aggregated and systematized information on the existing system of transport hubs to ensure the existing and future volumes of transportation of both humanitarian and industrial export-import cargo. Practical significance. The results obtained make it possible to lay a scientific basis for the concept of creating and developing a system of humanitarian and logistics hubs to improve the efficiency of moving cargo flows.
INVESTIGATION OF THE ALGORITHMS FOR THE TRANSPORT AND LOGISTICS PROCESSES OPTIMAL FORMATION BY HETEROGENEOUS OPERATORS IN REAL TIME
Authors: SKALOZUB V. , HORIACHKIN V. , SKALOZUB M. , TERLETSKII I.
Published: September 2022

The article presents the investigation results of the models and the algorithms for the formation of a wide range of transport and logistics real time processes, which create sorted structures of the mass orders. Operators of the different complexity, «weight» are used in this process. Different issues related to the creation of the formal models of the input data sets are resolved. They provide an effective implementation of the technological and the logistic processes. The purpose of the models is to improve the procedures for optimal ordering and classification of the sequences of analysing elements and orders. We have proposed new specialized models (graph models, binary trees) for the input (primary) sets of the elements, as well as algorithms for their processing, which ensure an efficiency increase of the ordering process components. In addition, graph models and algorithms allow solving classification tasks for the data of various types, and they are also suitable for organizing multi-sequencial orders. The high computational efficiency of the proposed new algorithms for arranging and classifying data has been established using comparative analysis. The article provides meaningful examples and notes the peculiarities of the tasks used for real time ordering and classification of the multi-sequencial orders. Namely, this is the task of disassembling and forming railway trains and the task of «mass order delivery to address». Examples of real time creation and transformation of the data flows binary graph models are provided to demonstrate the models and the algorithms. The formed models have been also applied to the tasks of effective sorting and classification with interval uncertainty of the data. We have investigated the possibilities of fuzzy arrangement structure creation and classification of numerical data received online.
The formal heterogeneity of allocutivity
Authors: Alok Deepak , Haddican Bill
Published: September 2022

Despite recent growth in formal work on allocutive marking, little work to date has considered the nature of cross-linguistic differences in the syntax of allocutive varieties, and what relationships, if any, exist among them. This paper summarizes recent formal results describing four kinds of variation across allocutive languages: (i) variable root-sensitivity; (ii) variation in allocutive morpheme placement; (iii) differences in allocutive morpheme type; and (iv) variation in interactions with clause typing and complementizers. We propose that the sole formal property unifying allocutive varieties is exponence of addressee features licensed by a silent Addressee DP. We further propose that variation in the properties of allocutive morphemes considered here reflect four principal loci of variation: (i) the position in which the silent Addressee DP may participate in allocutivity; (ii) the variable presence of a projection introducing an allocutive pronoun; (iii) the variable non-silence of a bound allocutive pronoun and/or the head introducing the Addressee DP; and (iv) agreement with other C-field heads. The analysis suggests that allocutivity involves greater formal heterogeneity than has been described previously in the literature. Principal aspects of cross-linguistic variation nevertheless can be modeled in terms of a limited set of formal options elsewhere motivated.
Una educación infantil sin maestros: igualdad versus desequilibrio
Authors: Peinado-Rodríguez Matilde
Published: September 2022

La falta de docentes varones en Educación Infantil no es un tema que preocupe a las administraciones educativas y, por tanto, no se han diseñado estrategias comunes para corregir este desequilibrio desde la Enseñanza Superior. En esta investigación nos proponemos entender los fundamentos ideológicos, sociales y contextuales que perpetúan esta situación en el siglo xxi y fundamentar por qué caminar hacia el equilibrio en el cuerpo docente de esta etapa educativa es una de las claves para la consecución de la igualdad y la corresponsabilidad en nuestro país. Para ello hemos tomado como herramienta metodológica la triangulación de datos cuantitativos de alumnado, entrevistas individuales y grupos de discusión. Finalmente, el profesorado en formación reflexiona en torno a dichas pervivencias y esbozan conjuntamente pautas educativas, políticas y sociales para la consecución de una igualdad efectiva como proyección de futuro.
Paradigma crítico de investigación y modelación matemática: transformaciones que desafían condiciones de vulnerabilidad social
Authors: Mancera-Ortiz Gabriel , Camelo-Bustos Francisco Javier , Araújo Jussara Loiola
Published: September 2022

En el presente artículo, de corte reflexivo, tenemos el objetivo de describir las influencias mutuas –y sus consecuencias– entre investigaciones que se apoyan en un paradigma crítico y los ambientes de modelación matemática orientados por una perspectiva sociocrítica desarrollada en un contexto de diversidad social y cultural. Para ello, reflexionamos sobre dos tesis doctorales cuyos datos se produjeron en el mismo contexto escolar –una escuela pública de la ciudad de Bogotá (Colombia)–, en dos momentos diferentes. Los participantes en la investigación son estudiantes que viven en una condición de vulnerabilidad social, entendida no solo como limitaciones económicas y estructurales, sino también como la (in)capacidad de reaccionar ante esta situación. La relación dialéctica entre las investigaciones y una serie de prácticas pedagógicas de modelación actuaron como motor de las transformaciones en las clases de matemáticas, que empezaron a considerar los contextos sociales, culturales y políticos de los estudiantes. La condición de vulnerabilidad social comenzó a tener visibilidad en las clases de matemáticas en cuanto fuente de temas para los ambientes de modelación matemática, lo que ocurrió tanto en las investigaciones realizadas como en ausencia de los investigadores. A partir de las reflexiones y los cuestionamientos que surgieron durante los ambientes de modelación, los estudiantes pudieron repensar su propia actuación en la sociedad y su condición de vulnerabilidad social, desafiándola.
Habitats and Characteristics of Sardina pilchardus, off the Moroccan Atlantic coast
Authors: Abdelaziz Mounir , Hassan Alahyane , Nor-eddine Chouikh , Nawal Hichami , Safaa Bendami
Published: September 2022

This paper is an overview of the main characteristics of Sardina on the Moroccan Atlantic coast. Sardine occupies an important place in the socio-economic context of Morocco and is the main species exploited on Moroccan coasts. It is the most important species in terms of catches and biomass. The small pelagic stocks in the area are exceptional wealth and as many opportunities in an international context, marked both by the scarcity of the resource and the need to make the sea c contribute more to food security and economic growth. The aim of this work is the study some features of S. pilchardus in the Moroccan waters.
Intentionality, Point of View, and the Role of the Interpreter
Authors: Ball Brian
Published: September 2022

The three main approaches to the metaphysics of intentionality can arguably be subjected to analysis in terms of grammatical point of view: the approach of the (internalist) phenomenal intentionality programme (plus productivism about linguistic content) may be regarded as first-personal; interpretationism, perhaps, as second-personal; and (reductive externalist) causal information theories (including teleosemantics) as third-personal. After making this plausible, the current paper focusses on the role of the interpreter (if any) in interpretationism. It argues that, despite some considerations from the publicity of meaning potentially suggesting the contrary, radical interpretation is not subject to epistemic constraint; nor should the interpretationist appeal to the idiosyncratic interests of actual interpreters, thereby rendering the approach irremediably relativistic. Instead, an appeal to the pure form of interestedness is all that is involved; this supports a methodologically non-reductive outlook on intentionality.
The Linguistic Landscape and Prospects of a Seaside Destination in the East of Thailand
Authors: Low Piyada
Published: September 2022

This study maps the linguistic landscape of the main 3-kilometer road to the Bang Saen Beach in East Thailand using images of roadside signs from Google Street View. In total, 7710 images of textual signs were taken over 7 years: 2012, 2016, 2017, 2018, 2019, 2020, and 2021. Most of the signs were monolingual (5119=66.39%), and Thai was dominant in the monolingual signs (3982=77.79%). The Thai-English combination was mostly found in bilingual signs (2476=97.74%). 2941 examples of Thai transliteration from foreign languages were found, and Thai transliteration from English was the highest (2857=97.15%). Findings on the use of different foreign languages indicated the increasing diversity and prospects of the research site. Notably, English was the most used foreign language.
Evaluating Lexical Complexity From EGP to ESP Textbooks
Authors: Ren Xiaobin
Published: September 2022

ESP classes are usually designed for college students after they finish EGP learning. Accordingly, ESP textbooks are used after they use the EGP ones. Logically, ESP textbooks should be lexically more sophisticated than EGP ones, because linguistic contents are also important concerns for ESP teaching, and ESP classes should also promote students’ language development in addition to their professional advancement. This research aims to compare lexical complexity between EGP and ESP textbooks used among college students. With lexical sophistication as an index for lexical complexity, this study found some ESP textbooks were lexically easier than the EGP ones in this study, which contrasts with input hypothesis. This implicates that ESP textbook writers should consider the contents of EGP textbooks when writing textbooks.
The Construal Configurations of Speakers’ Subjectivity in Narrative Fictions
Authors: Zhang Junling
Published: September 2022

The paper examines different degrees of the subjectivity of speakers who act respectively as a narrator, a character in the story, and the author in narrative fictions. According to the speaker’s four different cases of being on stage, off stage, whether serving as a reference point and cross-world identification, eight types of construal configurations of speaker’s subjectivity have been summarized. Findings show that the speaker is characterized to be maximally subjective when he/she is an author, and minimally subjective when he/she is a character in the story. The degree of speaker’s subjectivity is greater outside the story than that inside it, and it is also greater when he/she is being weakly perceived than that being strongly perceived. Overall, each configuration is a particular narrative strategy adopted by the author to achieve certain effects, and these configurations, to some extent, provide some cognitive interpretations for these achieved narrative effects.
Anomalous Thermomechanical Behaviour of Carbon Nanotube Bundle
Authors:   Institute for Metals Superplasticity Problems of RAS, Dmitriev S.V. ,   Institute of Molecule and Crystal Physics, Ufa Research Center of Russian Academy of Sciences, Galiakhmetova L.Kh. ,   Institute for Metals Superplasticity Problems of RAS, Korznikova E.A. ,   Institute for Metals Superplasticity Problems of RAS,   Institute of Molecule and Crystal Physics, Ufa Research Center of Russian Academy of Sciences
Published: September 2022

The molecular dynamics method is used to calculate the dependence of pressure on temperature at a constant volume for a bundle of carbon nanotubes (CNTs) considered under plane strain conditions. A chain model with a significantly reduced number of degrees of freedom is used for modeling. The influence of the CNT diameter is analyzed. It was found that for some parameters of the model, the pressure in the CNT bundle can decrease with increasing temperature, which is equivalent to the effect of negative thermal expansion.
Female Solo Self-Employment in Germany: The Role of Transitions and Learning From a Life Course Perspective
Authors: Haasler Simone R. , Hokema Anna
Published: September 2022

Based on a qualitative analysis of 12 solo self-employed women’s work biographies, this article investigates the (re)structuring effects of solo self-employment on the professional and private lives of women in Germany in their mid- and late-career stages. While solo self-employment has been gaining significance in the German labour market in the last two decades, it is largely an underresearched subject from the perspective of female labour market participation. Our study shows that the transition to working solo self-employed constitutes a marked break in female work biographies with lasting restructuring effects on their life courses. Constituting a deviation from the female standard life course, this move can be understood as a coping strategy of biographical discontinuities, which translates into specific patterns against the background that women (still) assume most of the care and housework responsibilities. How the transition to solo self-employment is being prepared and managed and what role learning and risk management play in the transition process is the focus of our article. Our aim is to better understand the underlining rationalisation logics of female solo self-employment in terms of labour market participation, reconciling work and family life, and professional self-realisation. While in the German welfare system solo self-employed bear higher risks of precarity and financial old age insecurity, solo self-employment is functional as an individual strategy for action, giving women the opportunity to do justice to their (mid) life courses and intrinsic needs to pursue both professional work and freedom of choice when and how to work. This may act as a corrective for gender inequalities in the world of work, especially when it comes to working in a self-determined way.
O papel educativo dos movementos sociais en España, entre o tardofranquismo e a transición democrática (1956-1982)
Authors: Rojas Sampedro Antonio
Published: September 2022

Na España do tardofranquismo e da Transición á democracia a poboación atopouse cada vez con máis espazos de sociabilidade en que estaban implicados activistas antifranquistas ou simplemente persoas que buscaban un cambio para establecer unha cultura democrática no conxunto da sociedade. Estes espazos agromaron a través dos diferentes movementos sociais que se deron nos ambientes universitarios e nos grandes conflitos obreiros, mais tamén noutros contextos como foi o movemento cidadán. Estes movementos sociais fóronse transformando en actores políticos, sociais e culturais ata converterse, mediante procesos de participación comunitaria, en espazos de educación cívica protagonistas dunha transición invisible; un proceso mediante o cal as persoas comezaban a interrogarse sobre a súa realidade como paso primeiro para a súa transformación. Podemos examinar este proceso á luz da educación social, e, incluso, tomando en consideración a teorización freiriana sobre os procesos dialóxicos de concienciación social comunitaria. Esta práctica educativa realízase a través dun proceso dialóxico que incorpora a acción e a reflexión en comunidade.
Letras entre ruecas, redes y arados. Mujeres y cultura letrada en Galicia (siglos XVIIXIX)
Authors: Suárez Golán Fernando
Published: September 2022

Esta obra tenta achegar respostas axustadas relativas á cuestión da cultura letrada feminina na Galiza do Antigo Réxime, determinada socialmente, en boa medida, polo peso da cultura oral e as fortes limitacións de acceso á cultura formal. A súa autora pertence a escola historiográfica dos modernistas que iniciara Antoino Eiras Roel, e aquí presenta un traballo (ensaio) sólido que aborda de maneira intensiva, onde non é menor a importancia das fontes históricas e á análise multicausal, xunto co emprego dun tratamento metodolóxico moi rigoroso.
Vermellos e laicos. A represión fascista do maxisterio coruñés
Authors: Iglesias Salvado José Luis
Published: September 2022

A depuración do maxisterio na provincia da Coruña, a partir de xullo de 1936 cando da comezo a guerra civil, é  o tema central que o profesor Narciso de Gabriel aborda de maneira exhaustiva nesta obra, para achegar unha análise precisa do proceso do que foron vítimas os mestres e as mestras e, por extensión, o sistema educativo que a Segunda República viña de construír desde 1931.
A School-based survey among adolescents on Dietary pattern, Exercise, and Knowledge of Cardiovascular risk factors (ADEK) Study
Authors: Munusamy G. , Shanmugam R.
Published: September 2022

Background. Cardiovascular disease is a global emerging problem and its risk starts in children and adolescents. Adolescents have modifiable cardiovascular risk factors that have been found globally, and nationally, and early intervention programs may be able to lower these risks for both individuals and populations. Accurate risk factor evaluation at the individual level is crucial in this situation for the prevention of cardiovascular disease. Objective. The study aimed to investigate cardiovascular disease knowledge and to determine physical activity, and dietary patterns among school-going adolescents in Arakkonam, Tamil Nadu, India. Methods. A school-based cross-sectional survey was conducted to assess cardiovascular disease knowledge among 500 adolescents aged 10-18 from public schools. The study period was from September 2021 to February 2022. The measurement taken on anthropometrics such as height, weight, body mass index, and bio-physiological measurement as blood pressure, structured questionnaire assessed for knowledge, dietary questionnaire assessed previous week food consumption which the investigator developed, and physical activity standard questionnaire assessed the past week’s exercise level. Data were analyzed using IBM Statistical Package for Social Sciences version 20. Results. The mean study population age was 13.7±1.7, 53% were boys, and 47% were girls. Factors like age 16-18 years (p=0.01), site of residence from urban (p=0.001), education of teenagers (p=0.01), and family history of cardiovascular disease (p=0.001) are significantly correlated with the level of knowledge score, with better-educated adolescents having fair knowledge score than others. Level of knowledge score and demographic traits are associated with physical activity, such as 16 to 18 years (p=0.03), living in an urban region (p=0.03), being in a joint household (p=0.001), adolescents who are at higher secondary (p=0.02), and having a family history contribute more to cardiovascular disease (p=0.001) than other variables. Mean days eating diets were egg (4.18±2.27), vegetables (3.92±0.93), milk products (3.85±1.87), fried foods (3.75±1.25), toffees, and chocolates (3.35±1.81) all had higher percentages of consumed foods than others. Conclusion: There is a risk of cardiovascular disease higher among adolescents. Still a need for school-based primordial preventive educational approaches needed to improve to curb this burden.
Multi Interventional Strategies on physiological and biochemical parameters on Polycystic Ovarian Syndrome – A Pilot Report
Authors: Niranjani S. , Bhuvaneswari G. , Hemamalini M. , Viyayaraghavan R.
Published: September 2022

Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous, chronic endocrine disorder commonly diagnosed in women of reproductive age. It often manifests with some or all of the following symptoms: menstrual dysfunction, infertility, hirsutism, acne, and obesity. Polycystic ovarian syndrome has now become one of the major health problem among adolescent and adult women. Lifestyle modifications, including diet modifications, exercise, and behavioral modification, appear to alleviate the metabolic dysfunction and improve the reproductive disorders of girls with PCOS. Therefore, lifestyle modifications have been gradually acknowledged as the first-line management for PCOS. Methods: Quantitative experimental and control group pre and post test design was used in this study.A total of 152 young girls from different colleges in Chennai were screened based on Rotterdam criteria and among that 30 study participants were selected who met the inclusion criteria. Structured self-administered questionnaire was used to elicit the baseline data. Participants were divided into three groups, 10 in each group – control group (only education regarding PCOS), experimental group I with all three interventions (cinnamon tea, exercise program and anxiety reduction counselling) given for 3 months, experimental group 2 with exercise program and anxiety reduction counselling given for 3 months. Post test I is conducted after 45 days and post test II is conducted after 3 months. Non probability Purposive sampling technique was used. Prior permissions were obtained from all the college principals and dean. Informed consent was obtained from all the participants. Results: This study shows that there was significant decrease (P<0.001) in the Physiological parameters (BMI, Waist circumference) and biochemical parameters (Total testosterone level) of experimental 1 group with multi interventional strategies (cinnamon tea, exercise program and anxiety reduction counselling) when compared to experimental 2 group and control group. There was better reduction in the experimental 2 group (exercise program and anxiety reduction counselling) when compared to the control group. There is increase in BMI, Waist circumference and total testosterone level in the control group when compared to experimental 1 and 2 groups. Conclusion: The present study highlighted the beneficial role of multi interventional strategies (cinnamon tea, exercise program and anxiety reduction counselling) in reducing the BMI, waist circumference and total testosterone level of young girls with Polycystic ovarian syndrome. Hence, the study recommends multi interventional strategies for young girls with Polycystic ovarian syndrome.
Level of Delirium and its Contributing Factor among Patients in ICU
Authors: Amzad S. , Barathi S.K. , Karpagam K.
Published: September 2022

Background: Delirium is an acute state of confusion characterized by a rapid onset, usually within hours to days, with changes in consciousness and cognitive changes. Delirium may also present as a form of agitation in intensive care patients. Delirium can affect up to 80% of patients in intensive care units and increase their length of stay and cost of hospitalization. Objectives: The main aim of the study is to evaluate the level of Delirium and its contributing factors among patients in intensive care unit. Methods: A descriptive study design was adopted for the study with 60 samples that met the inclusion criteria and were selected using convenience sampling technique. Data for demographic variables were collected using multiple-choice questionnaires, followed by assessment of delirium using the Confusion Assessment Method (CAM) scale. Results: 20%) had mild delirium, 13 samples (21.7%) of moderate delirium and 13 samples (21.7%) of severe delirium. Regarding the demographic variables of delirium, diabetes rapidly had a statistically significant association with the degree of delirium in ICU patients at p < 0.05. Conclusion: Confusion assessment method (CAM) is an effective to find out the level of delirium among intensive care unit patients.
A novel mutation of RPGR in a Chinese family with X-linked retinitis pigmentosa
Authors:   Children’s Hospital of Hebei Province, Shijiazhuang 050000, Hebei Province, China, Sun Hui-Hui , Yang Su-Ling ,   Children’s Hospital of Hebei Province, Shijiazhuang 050000, Hebei Province, China, Shi Jin-Dou ,   Hebei General Hospital, Shijiazhuang 050000, Hebei Province, China, Wei Yun-Shuo ,   Children’s Hospital of Hebei Province, Shijiazhuang 050000, Hebei Province, China, Wang Jian-Cang ,   Children’s Hospital of Hebei Province, Shijiazhuang 050000, Hebei Province, China, Gu Feng ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou 325027, Zhejiang Province, China, Chen Lu ,   Children’s Hospital of Hebei Province, Shijiazhuang 050000, Hebei Province, China
Published: September 2022

AIM: To identify potential mutations and elucidate the clinical findings of male patients and female carriers of X-linked retinitis pigmentosa (XLRP) in a Chinese family.
METHODS: A four generation pedigree was collected that consisted of 20 individuals. Genomic DNA was extracted from peripheral blood, and then the target fragments were amplified by PCR and sequenced directly. In addition, all affected patients and female carriers underwent comprehensively ophthalmic evaluation.
RESULTS: A novel mutation c.2865G>A p.W955X in RPGR gene was identified of this family, including four affected individuals and eight carriers. All male patients, aging from 7 to 31y, tended to have more various, even potentially deleterious clinical features of RP. At the same time, individuals with heterozygous mutations (carriers) manifested a wide spectrum of clinical features. Herein, only two male patients and three female carriers manifested pathological myopia (PM). Among the female carriers, half of subjects who harbor poor visual acuity suffered esotropia or exotropia. Additionally, 16.7% and 66.7% of carriers had abnormal electroretinogram (ERG) and fundus, respectively.
CONCLUSION: In this study, a novel mutation of the RPGR gene is identified, which broadens the spectrum of RPGR mutations, and elaborates the relationship between genotype and phenotype.
Análise Epidemiológica e Clínica de Casos de Sífilis Registrados em um Centro de Testagem e Aconselhamento
Authors: Dos Santos Juliana Lemes , Damiani Angela De Souza Garcia , Da Silva Geovane Barbosa , Mendes Graziella Alebrant , Coser Janaina , Pavan Zanella Janice De fátima
Published: September 2022

Objetivo: determinar  a prevalência de sífilis adquirida,  gestacional e congênita, bem como seus aspectos clínicos e epidemiológicos.Materiais e Métodos: estudo retrospectivo transversal, descritivo e analítico que teve como  amostra os dados clínicos e sociodemográficos de pacientes que foram diagnosticados com sífilis adquirida, sífilis congênita e sífilis gestacional no período de 2018 a 2019. Os dados clínicos compreenderam: forma da sífilis, idade, data do diagnóstico, forma de exposição, realização do pré-natal,  títulos de anticorpos e período da gestação. Já os dados sociodemográficos compreenderam: etnia, escolaridade, sexo e residência em zona rural ou zona urbana. As avaliações de diferenças estatísticas  foram verificadas pelo teste qui-quadrado de Pearson.Resultados: A idade média dos pacientes foi de de 30,3 anos (±11,9). A maioria dos participantes era do sexo feminino, de origem étnica branca, possuía escolaridade de nível médio incompleto e residia em zona urbana. Predominaram pacientes com sífilis adquirida, e que apresentaram níveis de titulação de anticorpos de 1:32. Também, os pacientes que tinham idade média de 32,7 anos tiveram relação estatística com a forma de notificação adquirida da sífilis.Conclusão: Esses resultados podem oferecer informações úteis para subsidiar as políticas de saúde na prevenção, no tratamento e acompanhamento desse grupo de pacientes.
Índice Inflamatório Dietético estimado por aplicativo e sua relação com aspectos clínicos e nutricionais de indivíduos renais crônicos dialíticos
Authors: Diógenes Pinheiro Irianne , Rebouças de Lima Ana Carolina , Rabelo Neto Matias , Freire da Silva Lucas , Santiago Cunha Magno , Santos Rocha Isabelle , Negreiros Holanda Daynara Vitória , Da Costa Silva Bruna Yhang
Published: September 2022

Introdução: Indivíduos com Doença Renal Crônica sob hemodiálise estão submetidos a uma inflamação intensa que pode ocasionar pior evolução da doença.Objetivo: Avaliar a relação entre o índice inflamatório dietético estimado pelo aplicativo IF Tracker® e os parâmetros clínicos e nutricionais desses pacientes.Métodos: Participaram 78 indivíduos. Coletou-se exames bioquímicos, pressão arterial intradialítica, peso, estatura, circunferências da cintura, do braço e muscular do braço, dobra cutânea tricipital e aplicou-se dois recordatórios alimentares de 24 horas. Relacionou-se os parâmetros clínicos e antropométricos com o índice de Reinagel através dos testes de Pearson e Spearman, considerando significante p<0,05.Resultados: Predominou dieta inflamatória, a qual se correlacionou com menores dobra cutânea tricipital, adequação de circunferência do braço e adequação de circunferência muscular do braço.Conclusão: Uma dieta anti-inflamatória pode beneficiar o estado nutricional de doentes renais crônicos sob hemodiálise e que o aplicativo IF Tracker® pode auxiliar no seu planejamento.
Imigrantes venezuelanos com deficiência: O Festival Paralímpico como facilitador no acesso a saúde
Authors: Cardoso Vinícius Denardin , Bastilha Rafaele Rodrigues , Nicoletti Lucas Portilho
Published: September 2022

Introdução: A Venezuela vive atualmente uma grave crise política, econômica e humanitária, que tem acarretado uma crescente mobilidade migratória de sua população. O Brasil é um dos principais países que recebe a população migrante venezuelano, que ingressa no país, em sua maioria pelo estado de Roraima. São inúmeras famílias que cruzam a fronteira em busca de melhores condições de vida. Crianças, jovens, adultos, idosos e também, pessoas com deficiência. O acesso desses imigrantes a saúde no país virou uma constante preocupação.Objetivo: Este estudo busca descrever as contribuições para a saúde de imigrantes venezuelanos com deficiência, após a participação em um festival esportivo em Boa Vista, Roraima. Materiais e métodos: O estudo caracteriza-se como descritivo e exploratório, com abordagem qualitativa. A coleta de informações foi realizada através de entrevista semiestruturada, com 03 sujeitos do gênero feminino, mães de 04 adolescentes com deficiência.Resultados: Os resultados indicam que: Reabilitação motora, Socialização e Melhorias em aspectos psicológicos são as principais contribuições destacadas após a participação no festival esportivo. Considerações finais: O esporte pode ser considerado um importante aliado para saúde dos imigrantes com deficiência, promovendo benefícios motores e psicológicos, e também, contribuindo para a integração destes na sociedade brasileira.
Análise dos Parâmetros Cinemáticos da Marcha de Gestantes Durante Atividades de Dupla Tarefa
Authors: Germano Sofia Toss , Bonfadini Vivian , Dos Santos Carolina De Quadros , Bernardon Dannielle Cristina Sanfelice , Saccani Raquel , Bonetti Leandro Viçosa
Published: September 2022

Objetivo: Verificar se atividades de dupla tarefa interferem nos parâmetros cinemáticos da marcha de gestantes.Materiais e métodos: Vinte e quatro mulheres, divididas em grupo gestante e não-gestante, fizeram parte da amostra. Primeiramente, foram realizadas as tarefas simples: tarefa simples (TS) da marcha, tarefa aritmética de subtração, de fluência verbal e de leitura no telefone celular. Após, as duplas tarefas (DTs) foram realizadas, onde a marcha foi executada ao mesmo tempo de cada uma das tarefas cognitivas. As variáveis da marcha analisadas foram velocidade, cadência, comprimento da passada, largura do passo e tempo da passada. Para as interações entre as tarefas e entre os grupos foi utilizado ANOVA mista, seguido do pós-hoc de Tukey e nível de significância adotado foi p < 0,05.Resultados: Nas comparações entre as tarefas, ambos os grupos não demonstraram alterações estatisticamente significativas da marcha quando comparada as DTs com a TS da marcha. Também não foram encontradas diferenças significativas da marcha na comparação entre os grupos.Conclusões: A não influência das DTs na marcha das gestantes se justifica pela pequena quantidade destas (apenas duas) estarem no terceiro trimestre gestacional; período onde ocorrem as mais significativas alterações cognitivas e que poderiam interferir na marcha desta população.
Os Efeitos Do Exercício No Desempenho Físico Em Idosos Residentes De Instituições De Longa Permanência: Uma Revisão Integrativa.
Authors: Penna Pinheiro Édila , Dos Santos Lemes Gabriel , Portes Juliana Katarina , Dos Santos Leonardo Peterson , Cavalheiro do Espírito Santo Rafaela , Machado Xavier Ricardo , Forgiarini Júnior Luiz Alberto , Filippin Lidiane Isabel
Published: September 2022

Introdução: Com o crescimento no número de idosos na população, cada vez mais surgem indivíduos incapacitados e dependentes de uma rede de cuidados. O treinamento físico pode ser uma intervenção efetiva para atenuar o declínio ou melhorar o desempenho físico relacionado com a idade.  Objetivo: sumarizar os efeitos dos exercícios no desempenho físico em idosos residentes de Instituições de Longa Permanência através da bateria de testes Short Physical Performance Battery, teste Levantar e caminhar, Teste de Sentar e levantar de 30 segundos. Materiais e Métodos: Foi realizada uma revisão integrativa da literatura empregando as bases de dados PubMed/ Medline, Scielo e Lilacs. Foram utilizadas as pesquisas que atendam os critérios de inclusão, sendo eles: pesquisa publicadas nos últimos 10 anos, de ensaios clínicos em adultos com mais de 60 anos residentes em Instituições de Longa Permanência e artigos com textos completos publicados em inglês ou português. Resultados: Considerando os critérios de inclusão, foram selecionados 32 estudos. O treinamento multicomponente foi utilizado em 11 estudos e os exercícios resistidos apareceu em 8, sendo as modalidades mais utilizadas. Conclusões: A revisão apontou que ambas as modalidades melhoram significativamente os parâmetros de desempenho físico relevantes para a capacidade funcional do idoso institucionalizado.
Aspectos clínicos e medidas fitoterápicas utilizadas no tratamento alternativo de acidentes por abelhas
Authors: Silva José Cleferson Alves Ferreira da , Costa Janielly Maria Pereira Santos , Santos Adriano José dos , Bezerra Maria Lusia de Morais Belo , Baltar Solma Lúcia Souto Maior de Araújo
Published: September 2022

Introdução: Em acidentes ocasionados por abelhas, plantas medicinais são amplamente utilizadas como tratamento fitoterápico emergencial. Objetivo: Conhecer os aspectos clínicos e as plantas medicinais utilizadas no tratamento das vítimas de acidentes por abelhas em dois municípios do sertão de Alagoas. Materiais e métodos: O estudo foi realizado nos municípios de Santana do Ipanema - AL e Olho D’água das Flores - AL. Os dados foram coletados através do método bola de neve e da aplicação de questionário semiestruturado. As variáveis (agente causador do acidente, aspectos clínicos, plantas medicinais utilizadas) foram analisadas através de metodologia investigativa e descritiva. Resultados: Foram registrados 32 casos de acidentes por abelhas. As partes do corpo mais afetadas foram as mãos e as principais manifestações clínicas predominantes foram os sintomas associados. Diante dos acidentes por abelhas nenhum indivíduo acidentado procurou atendimento médico, mas houve o relato do uso de plantas (Nicotiana tabacum, Ruta graveolens, Aloe vera, Lithraea brasiliensis, Citrus limon e Allium sativum) como tratamento alternativo. Conclusão: Utilizar plantas, diante desses acidentes, sem conhecer suas propriedades medicinais pode ser considerado como um fator de risco para as comunidades tradicionais. Dessa forma, é relevante que as comunidades tenham acesso às informações básicas para adoção do tratamento adequado.
Comparison of metabolic effects of mitochondrial dysfunctions in the context of vulnerability to fatigue: computer simulation study
Authors: Sabat Michał
Published: September 2022

In recent years, the accumulation of phosphate ions and the increase in acidity have been described as crucial metabolic fatigue-leading factors that disturb muscle fiber contractions. This fact is especially important in the context of mitochondrial dysfunctions in which excessive fatigue is one of the possible symptoms. However, little is known about the precise fatigue-inducing thresholds of work intensity in mitochondrial dysfunctions of various types and at various stages of their severity. Possible interactions of additional factors such as disturbances in electrolyte concentrations (i.e. magnesium ions) were also not precisely defined. One of the best-suited tools for this kind of problem is systems biology, which enables modeling of metabolic pathways. In this research, a computer model of working skeletal muscle was adapted. The relationship between the decrease in oxidative phosphorylation and the workload shows a linear dependence for dysfunctions that evenly disturb the activity of each element of the pathway (which is equivalent to the decrease in mitochondrial mass). In case of dysfunctions that disrupt only one element of the pathway, the relationship between fatigue threshold and exercise intensity is exponential, but with higher threshold deficiency values. Muscle phosphate levels were the most vulnerable to disruptions of complex III and ATP synthase. Surprisingly, disruptions of the ATP/ADP exchanger emerged as equally disruptive and capable of significantly increasing phosphate concentrations also in the rest state, whereas the impact of the impairment of the phosphate transporter was negligible. Perturbations in magnesium concentration also did not show a significant effect in any of these models.