bluuebunny/crossref_metadata_2025 huggingface dataset:
O DIREITO DE VIZINHANÇA E SUA REAL PROTEÇÃO
Authors: Marino Marcelo Giannobile
Published: November 2024

O presente artigo tem como propósito analisar o direito de vizinhança, conforme previsto no Código Civil brasileiro, e as interações entre proprietários e possuidores de imóveis contíguos. Busca-se, com isso, investigar a natureza das normas que visam à proteção dos direitos individuais no contexto das relações de vizinhança, tratando de temas como o uso normal e anormal da propriedade, as interferências prejudiciais, as árvores limítrofes, as passagens forçadas e o manejo das águas. A pesquisa conclui que o direito de vizinhança é essencial não apenas para assegurar a proteção dos direitos de propriedade, mas também para promover um ambiente de convivência harmoniosa, onde os interesses de todos os envolvidos são respeitados. Ao assegurar o equilíbrio entre a liberdade de uso da propriedade e a necessidade de proteção contra abusos e interferências indevidas, o direito de vizinhança desempenha um papel crucial na prevenção de conflitos e na promoção da ordem social.
VIOLÊNCIA DOMÉSTICA E O ACOLHIMENTO FEMININO: A IMPORTÂNCIA DAS CASAS DE APOIO PARA MULHERES VÍTIMAS
Authors: Cruz Vonera Fonseca da
Published: November 2024

This study addresses the issue of domestic violence against women, highlighting the role of shelters in Amazonas as essential instruments in breaking the cycle of violence. The general objective is to analyse how these institutions contribute to the protection and recovery of victims, providing comprehensive support that promotes their autonomy and security. The methodology applied is based on a theoretical and practical analysis of the functioning of shelters, assessing legislative aspects and their application in the state of Amazonas. The research reveals that sheltering offers a safe and structured environment where women receive psychological, legal, and social support, significantly contributing to breaking the violence cycle and rebuilding self-esteem. The results indicate that, beyond providing shelter, these facilities offer multidimensional support that helps victims understand their rights and develop the confidence necessary to break ties with the aggressor. The conclusions reinforce the importance of these shelters within the women's protection system, suggesting the need to improve shelter policies to fully ensure victims’ rights to safety and dignity. Expanding resources and continuous team training are recommended to ensure shelters in Amazonas can provide even more effective assistance to women in vulnerable situations.
COMPARATIVO TÉCNICO DA APLICAÇÃO DE TELHAS TERMO ACÚSTICAS E CERÂMICAS EM EDIFICAÇÕES RESIDENCIAIS EM PORTO VELHO
Authors: Sousa Diego Siqueira De , Silva Otávio Rodrigues Da , Neves Natália De Souza
Published: November 2024

In Porto Velho, Rondônia, where the climate is hot and humid, the choice between ceramic and thermal acoustic tiles has different impacts on the comfort and efficiency of buildings. Thermo-acoustic tiles stand out for their excellent thermal and acoustic insulation, making environments cooler and quieter, which is an advantage for those looking to reduce the use of air conditioning and minimize external noise. Ceramic tiles, although they offer lower insulating performance, are a more economical and durable alternative, being suitable for projects with a reduced budget and where thermal and acoustic control is not as necessary. Therefore, the decision must consider the balance between cost and comfort, according to the needs of the project and the local climate. The methodology applied to this research includes a bibliographical survey, being an applied research, which aims to provide greater depth on the subject and is also a descriptive qualitative research. In this way, we can understand that thermal acoustic tiles stand out in terms of advantages in their application in the city of Porto Velho, even though their cost is relatively higher, as their advantages stand out.
SUPLEMENTAÇÃO DE CÁLCIO NA MENOPAUSA PARA PREVENÇÃO DA OSTEOPOROSE: UMA REVISÃO DA LITERATURA
Authors: Salles Fátima Cristina Cavalcante , Burdelis Maria Cristina Delvage de Souza , Souza Nicole Dutra de , Graeff Simone Comelli da Silva , Buzzi Thaís Bonadio
Published: November 2024

Menopausa, um marco biológico que está associado à deficiência da densidade óssea e maior probabilidade do aparecimento da osteoporose. As informações abaixo, estão direcionadas a busca sobre a eficácia da suplementação do cálcio, como uma das estratégias de suplementação para o tratamento e prevenção da patologia citada, em mulheres que se encontram na fase pós menopausa. O estudo é direcionado ao levantamento de dados, que se relacionam com a dose adequada de cálcio, sua biodisponibilidade e seus efeitos adversos, se determinam a prevenção da perda óssea através de sua suplementação isolada, além de apresentar a relevância e atuação do profissional nutricionista inserido neste contexto. Importante ressaltar que vários estudos comprovam a eficácia do mineral cálcio, dependendo de fatores individualizados e adequações das doses propostas e a sinergia do mesmo com outras vitaminas e minerais. A metodologia utilizada foi desenvolvida através da revisão da literatura de artigos científicos de maior relevância ao tema, com periodicidade de 10 anos. Na busca dos artigos científicos publicados foram utilizados as seguintes palavras e associações: suplementação, cálcio, menopausa, osteoporose, diretrizes. Diante de todos os artigos pesquisados, referentes ao tema, concluiu-se que se faz necessário dar continuidade e maior abrangência ao leque de pesquisas, pois diante das informações obtidas, até o momento, não há um consenso de negação ou confirmação quanto às conclusões sobre o trabalho científico apresentando por Bolland et al. (2010), que evidenciou maiores probabilidades sobre o desenvolvimento de riscos cardiovasculares associados a suplementação do cálcio.
Secondary School Teachers Perception of Using ICT in the Classroom
Authors:   Monad University, Chauhan Dr. Deepika
Published: November 2024

This study explores secondary school teachers' perceptions of using Information and Communication Technology (ICT) as an instructional tool in schools across Uttar Pradesh, focusing on variations by stream, gender, and school management type. It also examines the availability of ICT resources and challenges faced by teachers in integrating these tools. Despite significant differences in ICT facilities among school types, teachers' perceptions of ICT do not vary significantly by gender, stream, or management type. Most teachers, regardless of these factors, view ICT as highly important for education. However, challenges such as hardware issues, lack of technical support, and inadequate training hinder effective ICT use. Notably, even teachers who don't actively use ICT in classrooms still have a high perception of its value, influenced by personal use and external exposure. The study employed a mixed-method approach, analyzing data through ANOVA and Chi-square tests, and highlights the potential for fostering learner centered environments given the generally positive teacher attitudes toward ICT.
The Role of Parents in Overcoming Moral Crisis in the Household
Authors: Fitriani Fitriani , Syafrizal Syafrizal , Aftika Aftika , Nurdianna Nurdianna , Putri Berlianda Indah , Guspita Rosi , Alias Muhamad Firdaus Bin
Published: November 2024

The role of parents in building a good household is very important. In instilling noble morals in children, parents are required to have various strategies so that their children's morals are formed according to what is expected. Parents' strategies for playing a role in dealing with moral crises in children and households cannot be separated from the Quran. This research aims to analyze Luqman's advice to his children based on the content of Surah Luqman verses: 13-19. This research uses a qualitative method with a content analysis approach, all data is taken from various sources originating from the Quran, theories and opinions of Islamic education experts. Then a theme is taken that matches the required data. After the author has collected all the data, the next step is to select the required data according to the problems raised in this article. Based on Luqman's letter, there are nine roles of parents in dealing with a moral crisis in the household, namely providing an example to children, always being ready to be a good listener, spending time together with family, giving clear expectations to children, don't let yourself feel guilty, don't replace love or time with money, don't change caregivers frequently, provide supervision, and provide punishment to educate.
Interpersonal Communication in the Character Building of Students in Islamic Boarding Schools
Authors: Dafrizal Dafrizal , Rohanis Rohanis , Alfriani Ranti Dwi , Faizah Tsamrotul , Yanderi Ismar
Published: November 2024

Islamic boarding schools are Islamic institutions that help and develop students from a religious perspective which includes character formation. One of the success factors in forming the character of students in Islamic boarding schools is the role of a teacher. A teacher must be able to communicate well with students by prioritizing student discipline and politeness. One of the communications carried out in developing students is interpersonal communication. This research aims to find out how teachers' interpersonal communication approaches and strategies shape the character of Islamic boarding school students in Indonesia. This research uses a qualitative method with a case study type. Data sources were taken from ten informants through direct interviews using a set of interview protocols. The informants consisted of teachers at Islamic boarding schools and students. All interview data obtained was analyzed thematically using the Milles & Hubberman Interactive Analysis Model technique. Research findings found three identification approaches and two interpersonal communication strategies used by teachers in forming students' characters. The three identification approaches are the cultural approach, the sociological approach, and the psychological approach. The two strategies used by the teacher are punishment and catalyst strategies. This research has revealed teachers' interpersonal communication approaches and strategies in shaping the character of Islamic boarding school students in Indonesia. Apart from that, the results of this research can be used as a reference for anyone who wants to manage an educational institution in the form of an Islamic boarding school.
Users’ perspectives of public library for a knowledge-based society: Implications for developing countries
Authors: Hosen Miraz , Jonayed
Published: November 2024

Rationale of Study – In today’s fast-paced, ever-changing world, knowledge has become a commodity and a capital that provides the basis for a knowledge-based society (KBS). Public libraries, however, are trying to stay relevant as a knowledge hub in such societies by expanding their roles in local communities. This research investigated the relationship among demography, accessibility, environment,digitalisation, and the library’s perceived role in a KBS.
Methodology – Following cross-sectional quantitative research design, data was collected from 112 respondents using a structured questionnaire survey on the premises of the Pabna Government Public Library in Bangladesh. The 9-item scale showed acceptable internal consistency (α = .713) and using SPSS 25, descriptive analyses, Chi-square test, and Spearman correlation were carried out.Findings – The role of a public library in terms of readership and awareness in the community had a statistically significant (p-value <0.001) positive correlation with accessibility (ρ=.334) and library environment (ρ=.513). At the same time, a negative association was observed with respondents’ level of education (ρ=-.265, p-value <0.01). However, a weak relationship existed between profession andperception of the library environment (ρ=.186, p-value <0.05).
Implications – In similar developing country contexts, libraries must attract diverse users beyond educated youths and create a conducive library environment where it becomes a part of their community. Public libraries can consequently stay relevant and contribute to building a KBS.
Originality – This paper reports the findings of an original study regarding users’ perceptions of public libraries in KBS from a developing country perspective.
Refute distorted allegations about freedom of speech, freedom of press, academic freedom, and cultural events in Vietnam
Authors: TRINH
Published: November 2024

On March 20, 2022, the US Department of State released its Annual Report on human rights situation in the world. The report contains a lot of false and distorted information about the situation regarding human rights in many countries, including Vietnam. Within the scope of this article, the author analyzes and refutes distorted allegations related to ensuring and enforcing the rights to freedom of speech, freedom of the press, academic freedom, and cultural events in Vietnam.
Privilège et sacrifice chez Simone Weil : entre décroissance de l’égo, attention impersonnelle et résistance au pouvoir
Authors: Devette Pascale
Published: November 2024

En proposant une distinction entre sacrifice contraint de l’attention et sacrifice consenti dans l’attention « impersonnelle », la pensée de Simone Weil offre une réponse à une vieille critique adressée aux éthiques du care, soit la promotion d’une morale sacrificielle au service du patriarcat. L’attention impersonnelle est un processus par lequel la personne s’arrache à ce qui, en elle, cristallise les rapports de pouvoir. Elle ouvre ainsi à une forme paradoxale de libération de soi et d’action : une déprise située, momentanée et temporaire des effets du pouvoir permettant une pleine réceptivité des autres.
Mères obliques, asymétrie et soutien chez Adriana Cavarero : esquisse d’un modèle incliné du sujet résilient1
Authors: Bourgault Sophie
Published: November 2024

Dans une entrevue tenue en 2008, la philosophe Adriana Cavarero soulignait l’importance de travailler « à partir des stéréotypes » patriarcaux et de resignifier ceux-ci à des fins féministes. Dans le présent article, l’autrice vise à analyser la manière dont se décline cette méthode de resignification dans l’ouvrage Inclinations, où Cavarero se réapproprie la figure stéréotypée de la mère sacrificielle afin de proposer une critique du sujet autosuffisant. L’article est consacré à l’examen du potentiel féministe et heuristique de ce sujet maternel incliné. Si Cavarero accorde une place trop discrète à l’ambivalence et aux affects négatifs accompagnant inévitablement le soin (care), l’autrice de l’article soutient néanmoins que la théorie de l’inclinaison cavareronienne – plus précisément son éloge du soutien, du relationnel et de l’asymétrie – constitue un puissant outil pour repenser le concept de résilience.
Particularités des violences à caractère sexuel vécues par des personnes LGBTQ du Québec
Authors: Doucet Sophie , Côté Isabel , Mantha Audrey , Blais Martin
Published: November 2024

Bien que les personnes lesbiennes, gaies, bisexuelles, trans et queers (LGBTQ) soient plus à risque d’être victimes de violences à caractère sexuel (VACS), peu d’études portent sur le sujet au Canada. Cet article cherche à mieux faire comprendre les particularités de ces violences sous-étudiées. Dans le cadre du projet de recherche SAVIE-LGBTQ, des entrevues semi-dirigées ont été réalisées auprès de 13 personnes LGBTQ vivant au Québec et ayant été victimes de VACS. Les résultats font émerger les éléments suivants : les personnes LGBTQ survivantes de VACS peuvent remettre en question leur identité à la suite de l’agression; certains agresseurs ont utilisé l’orientation sexuelle ou l’identité de genre de la personne pour justifier les gestes posés; enfin, s’identifier comme une personne issue des communautés LGBTQ complique la demande d’aide.
Vehicle-to-Everything: Cybersecurity and Quality of Service Challenges
Authors: Timčenko Valentina , Boštjančič Rakas Slavica
Published: November 2024

This paper is focused to the emerging technological development in the area of the advanced vehicular communication systems. It considers the most up to date Vehicular to Everything technologies and discusses the typical scenarios related to the communication between vehicles, between vehicles and infrastructure, vehicles and pedestrians and communication between vehicles and network environment. Paper also considers the arising issues and countermeasures related to the security, privacy and quality of service (QoS) as well as predictive QoS aspects.
Práticas epidemiológicas nos serviços de saúde: arranjos tecnológicos
Authors: Barradas Barata Rita
Published: November 2024

A obra trata da epidemiologia nos serviços de saúde do Sistema Único de Saúde (SUS), e diferentes arranjos tecnológicos, influenciados pelo saber epidemiológico, disponíveis para a organização das práticas em saúde coletiva.
The Shadows of Internationalisation
Authors: Shenderova Svetlana , Jokila Suvi , Anafinova Saule , Liu Yingxin (Margaret) , Sharma Harshita , Steane Natalya
Published: November 2024

This forum proposes the use of concept of “shadows” in the analysis of internationalisation policies to make visible the decision-making processes and practices appearing at all levels of internationalisation policies. We focus on the problematic effects appeared at the intersect of internationalisation policies implemented by the countries perceived academic values differently on example of Finland as the EU member state and pre-war Russia. We consider these effects as preventing equal access to quality higher education and life-long learning for all (SDG4, target 4.3). The forum conceptualises the lessons of the EU/Finnish-Russian internationalisation for further usage the suggested theoretical lens in policy implementation in other countries developed their own internationalisation policy on different value basis. This study address to what happens when the internationalisation policies promoted European view on fundamental academic values, are implemented with such policies in the countries where these values are perceived in another way. We answer the question of how and why the shadows of internationalisation appear and have an impact at a macro-, meso-, and micro-level, and conceptualize them for future policy improvement. The forum discusses the implications of internationalisation policies from the practice perspective and what might be learnt by the stakeholders previously involved in these cooperation partnerships.
Aplicação do desdobramento da função qualidade (QFD) para a melhoria dos serviços em uma clínica de saúde ocupacional
Authors: Bordenski Sttefani Caroline , Silva Robson de Faria , Ellwanger Manuela Pozza , Bendlin Luciano
Published: November 2024

Este estudo explorou a aplicação do Desdobramento da Função Qualidade (QFD) em uma clínica de saúde ocupacional, com o objetivo de identificar pontos de melhoria para os serviços prestados. Um questionário semiestruturado foi aplicado a uma amostra de clientes da clínica, avaliando a gama de serviços e a satisfação dos clientes. A voz do cliente foi relacionada com requisitos técnicos por meio de especialistas. As descobertas revelaram que o tempo de espera e o atendimento são os requisitos mais relevantes para os pacientes. A clínica deve melhorar esses aspectos, especialmente em comparação aos concorrentes. Estratégias para rapidez no atendimento e personalização do serviço foram priorizadas. Este estudo contribui para a gestão da qualidade no setor de saúde, demonstrando como o QFD pode ser efetivamente adaptado para melhorar a satisfação do cliente e a eficiência operacional.
Influence of Farmer’s Income Level on Adoption of Agricultural Water Management Practices among Smallholder Farmers in Rongai Sub-county, Kenya
Authors: Mwangi Mercy Wagaitheri , Ngesa Fredrick , Mwaniki Susan M.Wanyaga
Published: November 2024

Water is a resource that cannot be replaced and can only be renewed if it is well managed. It is basic for all forms of life, for every aspects of socio-economic development, and for the maintenance of a healthy ecosystem. Agriculture is the biggest water user globally, accounting for 70 percent of total water withdrawals on average. There are different practices that can aid in managing water used for agriculture. Some of these agricultural water management practices are; rainwater harvesting, irrigation, organic farming, and use of drought resistant crops. Farmer’s decision to either adopt or reject these practices can be affected by several factors, some of which are socio-economic. Some of the socio-economic factors that may influence adoption of these practices include farmer’s educational level, income level and farm size. This study examined the influence of farmer’s income level on adoption of agricultural water management practices (Rainwater harvesting, Irrigation Drought resistant crops). Cross-sectional survey design was adopted, while proportionate and simple random sampling technique was used to obtain the respondents. The accessible population was 6,230 smallholder farmers from the target population of 26,804 smallholder farmers in Rongai sub county Kenya. The study was done in August 2023 to November 2023.The study included 120 smallholder farmers in Rongai Sub County. The study used questionnaire to collect data while binary logistic regression was used to analyze the data. The results indicated that adoption of agricultural water management practices is low, only 36% of smallholder farmers had adopted agricultural water management practices. The P value calculated for the 120 smallholder farmers was P=.033 which is < than .05 and therefore the null hypothesis was rejected concluding that in this study income level had  statistically significant influence on adoption of agricultural water management practices among smallholder farmers in Rongai sub-county in Nakuru ,Kenya. The findings may help in emphasizing the necessity of assisting farmers in removing financial obstacles that may hinder adoption of agricultural water management practices.
Optimizing Hotel Marketing: An Analysis of Instagram Algorithms in 2024
Authors: Chendra Sharon Victoria , Setiawan Budi
Published: November 2024

This study examines Instagram's effectiveness as a marketing tool for hotels by analyzing the platform's algorithm, shadowbanning risks, and content optimization strategies. The purpose of this research is to assess how Instagram’s algorithm can be leveraged to enhance hotel visibility and credibility. Using qualitative methods, including a literature review of research papers, case studies, books, and reports, data is collected and analyzed through content analysis to identify key factors influencing content visibility, engagement, and overall performance on Instagram. The findings offer valuable insights for hotels aiming to optimize their marketing strategies on Instagram. The research emphasizes the importance of understanding Instagram’s algorithm and adjusting content strategies to align with trends and algorithms. Key recommendations include focusing on high-quality, engaging content, avoiding shadowbanning practices, and utilizing user-generated content to build customer loyalty. By implementing these strategies, hotels can effectively engage their target audience, showcase their brand, and drive bookings in today’s competitive digital landscape.
The Evolution of Cameroonian Cooperation with the Soviet Union and the Russian Federation: A Historical and Geopolitical Analysis
Authors: Dieunedort Tchomeni , Nawal Chetfon , Viny Djongoue Tchoula
Published: November 2024

This paper investigates the historical and evolving relationship between Cameroon and the Soviet Union and later, the Russian Federation, focusing on political, military, economic, and cultural dimensions. Positioned strategically at the crossroads of West and Central Africa, Cameroon has balanced longstanding ties with France against a growing partnership with Russia. Since the Soviet Union’s formal recognition of Cameroon's independence in 1964, Soviet support in education, infrastructure, and ideological alignment contributed to a foundational relationship grounded in anti-colonial and socialist values. Following the dissolution of the Soviet Union in 1991, relations were reestablished with the Russian Federation, shifting from ideological alignment to pragmatic cooperation, particularly in defense and economic engagement. Key findings indicate that Russia cooperation with Cameroon cut across education, reciprocal visa exemption agreement for holders of diplomatic and service passports, food trade and military defense. The study uses a qualitative methodology, incorporating primary sources such as government records, treaty documents, and public statements, alongside secondary sources including academic articles and policy analyses. This approach allows for an examination of key historical milestones, the role of security concerns, and economic priorities that have shaped Cameroonian-Russian relations over the years.
Genetic Variability in Fusarium Wilt Resistant BC2F1 Lines of Yard Long Bean (Vigna unguiculata subsp. sesquipedalis (L.) Verdcourt) Variety Githika for Yield and its Related Traits
Authors: R Sreeja , M S Niveditha , G Seeja , A Sajeena , C Ninitha Nath
Published: November 2024

Yardlong bean is a highly popular and profitable vegetable traditionally cultivated in the humid tropics of Kerala and is an inexpensive source of vegetable protein. Developing sustainable host plant resistance mechanisms, such as using the backcross method to introduce single-gene resistance into susceptible crop varieties, is crucial for reducing losses due to Fusarium wilt. In the present study Thirty-five resistant backcross progenies (BC2F1) of Yardlong Bean (Vigna unguiculata subsp. sesquipedalis (L.) Verdcourt) variety Githika were evaluated for various genetic parameters for yield and its related traits using Completely Randomized Design at Department of Genetics and Plant Breeding, College of Agriculture, Vellayani, Trivandrum. High phenotypic coefficient of variation (PCV) and genotypic coefficient of variation (GCV) were observed for traits such as the number of pods per plant, pod weight, pod yield per plant, crude protein content. High Heritability(H) and High Genetic advance as percent mean (GAM) were observed for traits such as Number of pods per plant, Pod weight, Pod length, Number of seeds per pod, Pod Yield per plant, Crude fibre and Crude protein content. This significantly suggest that additive gene action is predominant in these traits and low reliance by environmental factors on these traits, making such character a good candidate for direct selection. The study helps in assessing genetic variability to identify traits as well as lines with maximum similarity with recurrent parent which could be used for further crop improvement program.
Impact of Improper Waste Disposal on Surface and Ground Water
Authors: Ed-Idoko J. O. , Apochi J. O. , Ndukwe J. , Tanimowo A. O. , Abidang F. I. , Christiana O. N. , Ibrahim U. O.
Published: November 2024

Pollution in water occurs when harmful substance (often chemicals or biological) contaminate streams, river, lakes, oceans or other bodies of water, degrading water quality and rendering it unhealthy to humans, animal and the environment. The widespread problem of water pollution is jeopardizing our health. Water pathogens, in form of disease-causing bacteria and viruses from human and animal waste, are a major reason of illness from contaminated drinking water. Owing to the improper treatment facilities, waste is often discharged into the surface and ground water sources. Water bacteria can be limited by recycling used plastic, standard disposal of chemicals, oils or non-biodegradable items and proper collection and transportation of solid waste to a processed disposal site. In addition, waste water should be treated properly to prevent adverse health risk of the user of both surface water and ground water in the aquatic ecosystems.
Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study
Authors: Veronese Nicola , Koyanagi Ai , Stubbs Brendon , Cooper Cyrus , Guglielmi Giuseppe , Rizzoli Renè , Schofield Patricia , Punzi Leonardo , Al‐Daghri Nasser , Smith Lee , Maggi Stefania , Reginster Jean‐Yves
Published: August 2018

Objective

Statins have several pleiotropic effects, but the literature regarding the possible relationship between use of statins and outcomes in knee osteoarthritis (OA) is limited. The aim of this study was to investigate whether statin use is associated with a lower risk of radiographic OA (ROA), radiographic symptomatic knee OA, and pain in North American individuals.

Methods

A total of 4,448 community‐dwelling adults from the Osteoarthritis Initiative were followed for 4 years. Statin use (including the time from baseline and the type of statin) was defined through self‐report information and confirmed by a trained interviewer. Knee OA outcomes included incident ROA, symptomatic knee OA (new onset of a combination of a painful knee and ROA), and knee pain worsening (i.e., a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual examination ≥14%).

Results

At baseline, 1,127 participants (25.3% of the total population) used statins. Based on a multivariable Poisson regression analysis with robust variance estimators, any use of statins was not associated with a lower risk of pain worsening (relative risk [RR] 0.97, 95% confidence interval [95% CI] 0.93–1.02), incident ROA, or symptomatic knee OA. However, statin use for more than 5 years (RR 0.91, 95% CI 0.83–0.997) and use of atorvastatin (RR 0.95, 95% CI 0.91–0.996) were associated with a reduced risk of developing pain, while rosuvastatin use was associated with a higher risk (RR 1.18, 95% CI 1.12–1.24). Analysis with adjustment for the propensity score confirmed these findings.

Conclusion

The effect of statin use on knee OA outcomes remains unclear, although in our study, a significantly lower risk of developing knee pain was observed in individuals using statins for >5 years and those using atorvastatin.
Catalytic Asymmetric [4+2] Cyclization of para‐Quinone Methide Derivatives with 3‐Alkyl‐2‐vinylindoles
Authors: Jiang Xiao‐Li , Wu Shu‐Fang , Wang Jin‐Rong , Mei Guang‐Jian , Shi Feng
Published: August 2018

A catalytic asymmetric [4+2] cyclization of para‐quinone methide (p‐QM) derivatives with 3‐alkyl‐2‐vinylindoles in the presence of a chiral phosphoric acid has been established, and this method provides chiral chroman frameworks in good yields (up to 98%) with high diastereoselectivities (up to >95:5 dr) and excellent enantioselectivities (up to 96% ee). This reaction represents the first catalytic asymmetric [4+2] cyclization of p‐QM derivatives with electron‐rich alkenes, which will enrich the field of catalytic asymmetric reactions of p‐QM derivatives. In addition, this catalytic asymmetric cyclization was successfully applied to 3‐alkyl‐2‐vinylindoles. More importantly, this reaction will offer a useful method for the construction of enantioenriched chroman frameworks.

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Cervical esophageal perforation during endoscopic ultrasonography: A retrospective evaluation of frequency, outcome, and patient management
Authors: Yu Chia‐Ying , Chien Cheng‐Hung , Hsieh Po‐Jen , Chien Rong‐Nan
Published: August 2018

To analyze the indications and complications of diagnostic endoscopic ultrasonography (EUS) within a 12‐year period in our hospital. We retrospectively reviewed all patients who received upper gastrointestinal EUS at Keelung Chang Gung Memorial Hospital from January 2002 to December 2013. The examination was performed using a radial scanning echo endoscope (Olympus GF‐UMQ 240 before August 2011; Olympus GF‐UE 260‐AL5 after September 2011). The indications as well as complications were reviewed. A total of 839 patients underwent a total of 1036 procedures. Mean age of the patients was 59 years (range, 16‐102 years); 56.3% of patients were men. The indications for EUS were: evaluation of gastric submucosal tumors in 425 patients (41%), esophageal cancer staging in 247 patients (23.8%), evaluation of esophageal submucosal tumors in 91 patients (8.8%), evaluation of pancreatic lesions in 66 patients (6.4%), gastric cancer staging in 66 patients (6.4%), and evaluation of biliary lesions in 53 patients (5.1%). Only one patient (0.096%) developed a major complication (cervical esophageal perforation). Fortunately, the patient recovered smoothly after a surgical repair and felt well at 5‐year follow up. Cervical esophageal perforation is a rare but catastrophic complication of EUS. Advanced age, history of difficult intubation, cervical osteophytes, and less experienced doctors are documented to be the risk factors for perforation. In addition, surgeons should pay more attention to those who have a history of thyroidectomy. Immediate recognition of the perforation and urgent primary surgical repair results in a favorable outcome.
Undifferentiated embryonal sarcoma of the liver in an adult: Case report and literature review
Authors: Liao Min‐Kai , Chen Kuan‐Yang , Zhang Ting‐An , Lin Chih‐Lin , Lin Tsung‐Jung , Liao Li‐Ying , Wang Chung‐Kwe , Lee Hsi‐Chang
Published: August 2018

Undifferentiated embryonal sarcoma of the liver often presents in the childhood. Its occurrence rate in adults is extremely low. A 70‐year‐old woman suffered from right upper quadrant abdominal pain, fever, and body weight loss of 10 kg over half a year. Abdominal ultrasonography and computed tomography revealed one 9‐cm tumor with a cystic component at S6/S7 of the liver. The tumor markers, such as serum alpha‐fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19‐9, were in the normal range. Repeated biopsies showed no malignancy. After exclusion of infectious diseases through an inflammation scan, she underwent S6/7 bisegmentectomy. The final report of pathology was undifferentiated embryonal sarcoma. No evidence of recurrence or metastases was noted during follow‐up visits. The rate of misdiagnosis before operation is high. The enhancing of radiological feature‐reading skills and clinical awareness are considered to be necessary to reduce misdiagnosis. The prognosis was considered to be poor before. Multimodal treatment with complete surgical excision and chemotherapy provided the best chance of long‐term disease‐free survival. We concluded that undifferentiated embryonal sarcoma should be included in the differential diagnostic list of malignant liver tumors in adults.
TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton
Authors: Burren Christine P. , Caswell Richard , Castle Bruce , Welch C. Ross , Hilliard Tom N. , Smithson Sarah F. , Ellard Sian
Published: August 2018

Transient receptor potential vanilloid 6 (TRPV6) functions in tetramer form for calcium transport. Until now, TRPV6 has not been linked with skeletal development disorders. An infant with antenatal onset thoracic insufficiency required significant ventilatory support. Skeletal survey showed generalized marked undermineralization, hypoplastic fractured ribs, metaphyseal fractures, and extensive periosteal reaction along femoral, tibial, and humeral diaphyses. Parathyroid hormone (PTH) elevation (53.4–101 pmol/L) initially suggested PTH signaling disorders. Progressively, biochemical normalization with radiological mineralization suggested recovery from in utero pathophysiology. Genomic testing was undertaken and in silico protein modeling of variants. No abnormalities in antenatal CGH array or UPD14 testing. Postnatal molecular genetic analysis found no causative variants in CASR, GNA11, APS21, or a 336 gene skeletal dysplasia panel investigated by whole exome sequencing. Trio exome analysis identified compound heterozygous TRPV6 likely pathogenic variants: novel maternally inherited missense variant, c.1978G > C p.(Gly660Arg), and paternally inherited nonsense variant, c.1528C > T p.(Arg510Ter), confirming recessive inheritance. p.(Gly660Arg) generates a large side chain protruding from the C‐terminal hook into the interface with the adjacent TRPV6 subunit. In silico protein modeling suggests steric clashes between interface residues, decreased C‐terminal hook, and TRPV6 tetramer stability. The p.(Gly660Arg) variant is predicted to result in profound loss of TRPV6 activity. This first case of a novel dysplasia features severe but improving perinatal abnormalities. The TRPV6 compound heterozygous variants appear likely to interfere with fetoplacental calcium transfer crucial for in utero skeletal development. Astute clinical interpretation of evolving perinatal abnormalities remains valuable in complex calcium and bone pathophysiology and informs exome sequencing interpretation.
Familial dominant epilepsy and mild pachygyria associated with a constitutional LIS1 mutation
Authors: De Vita Dalila , Mei Davide , Rutigliano Domenico , Bartalucci Niccolò , Cinnante Claudia Maria , Parrini Elena , Dilena Robertino , Guerrini Renzo
Published: August 2018

We describe a mother and son with focal epilepsy, mild cognitive impairment, and pachygyria, which was parieto‐occipital in the mother and with remarkable posterior greater than anterior severity in the son. Overall clinical manifestations, although overlapping in type, were likewise slightly more severe in the son. Using targeted resequencing through a gene panel for malformations of cortical development, we identified the c.655 T > A [p.(Trp219Arg)] novel missense variant in the LIS1 gene, segregating in the proband and in his mother. Western Blot analysis, qPCR gene expression and RT‐PCR disclosed no significant differences between proband, his parents, and controls. Epilepsy and mild cognitive impairment can be the only clinical presentation of constitutional LIS1 mutations, which can therefore be inherited if the associated phenotype implies limited or no reproductive disadvantage. Parents of patients harboring LIS1 mutations should be assessed for their mutation carrier status.
Towards Dynamic but Supertough Healable Polymers through Biomimetic Hierarchical Hydrogen‐Bonding Interactions
Authors: Song Yan , Liu Yuan , Qi Tao , Li Guo Liang
Published: August 2018

A biomimetic (titin protein molecular structure) strategy is reported for preparing transparent and healable elastomers featuring supertoughness (345 MJ m−3) and high tensile strength (44 MPa) after self‐healing enabled by hierarchical (single, double, and quadruple) hydrogen‐bonding moieties in the polymer backbone. The rigid domain containing hierarchical H‐bonds formed with urethane, urea, and 2‐ureido‐4[1H]‐pyrimidinone groups leads to a durable network structure that has enhanced mechanical properties and is also dynamic for rapid self‐healing. Healable polymers with hierarchical hydrogen‐bonding interactions show excellent recoverability and high energy dissipation owing to the durable interaction between polymer chains. This biomimetic strategy of using hierarchical hydrogen bonds as building blocks is an alternative approach for obtaining dynamic, strong, yet smart self‐healing polymers for heavy‐duty protection materials and wearable electronics.
Undecabenzo[7]superhelicene: A Helical Nanographene Ribbon as a Circularly Polarized Luminescence Emitter
Authors: Cruz Carlos M. , Castro‐Fernández Silvia , Maçôas Ermelinda , Cuerva Juan M. , Campaña Araceli G.
Published: August 2018

The synthesis and characterization of an enantiopure superhelicene nanographene is reported in which two saddle‐shaped and one planar hexabenzocoronene (HBC) units are arranged in a helicoidal shape to form an undecabenzo[7]carbohelicene. The described compound is the first fully π‐extended [7]helicene. Racemic resolution of the helical nanographene permitted analysis of the chiroptical properties and revealed dissymmetry factors in the range of 2×10−3 both in the absorption and in the emission measurements. Remarkably, non‐linear photophysical analysis demonstrated a two‐photon absorption cross‐section of 870 GM at 800 nm and a perfect overlap between linear, non‐linear, and chiral emissions.
Catalytic Regio‐ and Enantioselective Alkylation of Conjugated Dienyl Amides
Authors: Guo Yafei , Kootstra Johanan , Harutyunyan Syuzanna R.
Published: August 2018

A method for catalytic asymmetric alkylation of conjugated dienyl amides has been developed and it allows efficient and high‐yielding transformations of a wide range of polyconjugated amides into the corresponding chiral products. Smooth addition of organomagnesium reagents to relatively unreactive dienyl amides with excellent 1,6‐ and 1,4‐selectivities, as well as enantioselectivites above 90 %, is achieved owing to the complementary action of the Lewis acid and a chiral copper‐based catalyst.
Heavily Doped and Highly Conductive Hierarchical Nanoporous Graphene for Electrochemical Hydrogen Production
Authors: Chen Linghan , Han Jiuhui , Ito Yoshikazu , Fujita Takeshi , Huang Gang , Hu Kailong , Hirata Akihiko , Watanabe Kentaro , Chen Mingwei
Published: August 2018

Heavy chemical doping and high electrical conductivity are two key factors for metal‐free graphene electrocatalysts to realize superior catalytic performance toward hydrogen evolution. However, heavy chemical doping usually leads to the reduction of electrical conductivity because the catalytically active dopants give rise to additional electron scattering and hence increased electrical resistance. A hierarchical nanoporous graphene, which is comprised of heavily chemical doped domains and a highly conductive pure graphene substrate, is reported. The hierarchical nanoporous graphene can host a remarkably high concentration of N and S dopants up to 9.0 at % without sacrificing the excellent electrical conductivity of graphene. The combination of heavy chemical doping and high conductivity results in high catalytic activity toward electrochemical hydrogen production. This study has an important implication in developing multi‐functional electrocatalysts by 3D nanoarchitecture design.
The role of water in plasticizing thermally aggregated protein‐based thermoplastics
Authors: Uitto Jussi M. , Verbeek Casparus J. R.
Published: August 2018

Blood meal‐based thermoplastic protein (Novatein) is made from a highly aggregated protein network, and as a result, water plays a significant role during plasticization. Novatein was plasticized with up to 40 parts tri(ethylene glycol) or glycerol and equilibrated at different relative humidities. The equilibrium moisture content (EMC) was the dominant factor determining mechanical properties, with a brittle to ductile transformation observed at 8% EMC. However, EMC was not sufficient to explain this behavior and the point of equivalence (POE) was introduced to differentiate between primary and secondary plasticization. It was shown that the constraint theory, which relates to hydrogen bonding plasticizers, was more applicable below the POE whereas the free volume theory, and the formation of the microscale phase separation, described material behavior above the POE. Water played a critical role improving ideal mixing conditions in the material and was also related to the brittle‐to‐ductile transition. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46746.
Synthesis and characterization of a novel difluoromethylene phosphonic acid functionalized polymer
Authors: Alter Christian , Hoge Berthold
Published: August 2018

A novel polymer featuring difluoromethylene phosphonic acid functions was prepared by free radical polymerization of a styrene monomer that is decorated by phosphonic ester groups. The obtained polymer was analyzed by gel permeation chromatography, differential scanning calorimetry, and spectroscopy (NMR, infrared). Treatment of the polymeric phosphonic ester with Me3SiBr led to an exchange of the ethyl groups by trimethylsilyl units in the P‐containing part of the material. Desilylation to the free phosphonic acid functions was effected by water. The ion exchange capacity was determined to be 7.3 mmol/g by titration with 0.1 M NaOH. The proton conductivity in the anhydrous state was studied by electrochemical impedance spectroscopy. The conductivity of 1.76 × 10−5 S cm−1 at 120 °C is well comparable with that of Nafion (7.66 × 10−5 S cm−1 at 120 °C), and renders this polymeric phosphonic acid as a promising candidate for proton conduction applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46765.
Properties of PLA/PMMA blends with high polylactide content prepared by reactive mixing in presence of poly(styrene‐co‐glycidyl methacrylate) copolymer
Authors: Anakabe J. , Orue A. , Zaldua Huici A. M. , Eceiza A. , Arbelaiz A.
Published: August 2018

Polylactide/poly(methyl methacrylate) blends with high polylactide content (100/0, 95/5, 90/10, 85/15, and 80/20 wt %) were prepared in presence of poly(styrene‐co‐glycidyl methacrylate) copolymer by reactive melt‐blending. The behavior of these blends was studied by torque monitoring while blending and the thermal properties, mechanical properties, and the morphological study of the produced blends was carried out by differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis, tensile test, impact test, and scanning electron microscopy. In situ torque monitoring during blend preparation suggested no reactivity between the copolymer and poly(methyl methacrylate), while it proved reactivity with polylactide. It was observed that a higher copolymer‐to‐polylactide weight ratio lead to an increase in the slope of the torque‐time curve. At least around 15 wt % of poly(methyl methacrylate) was required to achieve interesting properties. Polylactide/poly(methyl methacrylate) blended at 80/20 wt % containing 3 pph of copolymer showed a huge enhancement of elongation at break value and improved impact resistance compared with neat polylactide, while keeping the tensile modulus and strength over 3 GPa and 60 MPa, respectively. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46825.
Effect of core–shell structures of acrylonitrile–styrene–acrylate (ASA) terpolymer on the properties of poly(vinyl chloride) (PVC)/ASA blends: Miscibility, toughness, and heat resistance
Authors: Zhang Xueqiang , Zhang Jun
Published: August 2018

In this work, acrylonitrile–styrene–acrylate (ASA) terpolymer was used to toughen rigid poly(vinyl chloride) (PVC). ASA has a core–shell structure, where the poly(butyl acrylate) (PBA) serves as the soft core while styrene‐acrylonitrile (SAN) copolymer works as the rigid shell. Herein, The PBA core content in ASA was varied from 0 to 80 wt %, and its effect on the physiochemical properties was investigated. It was found that the hard shell of ASA was miscible with PVC matrix, providing good interfacial adhesion between ASA and PVC. Increasing the soft PBA content considerably improved the room‐temperature impact toughness, and a sharp brittle–ductile transition (BDT) as a function of PBA content was observed. However, as the testing temperature decreased to 0 and −30 °C, the toughening effect became limited, and the BDT first shifted to high PBA content region and finally disappeared. It was suggested that whether the toughening effect can be achieved depended on the thickness of hard shell and the relaxation behavior of PBA core. Albeit the loss in rigidity was accompanied, the accomplished toughening effect was not on the sacrifice of heat distortion temperature. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46839.