bluuebunny/crossref_metadata_2025 huggingface dataset:
Failed Stopping Transiently Suppresses the Electromyogram in Task-Irrelevant Muscles
Authors: Mills Isaiah , Fisher Mitchell , Wadsley Corey George , Greenhouse Ian
Published: January 2025

Selectively stopping individual parts of planned or ongoing movements is an everyday motor skill. For example, while walking in public, you may stop yourself from waving at a stranger who you mistook for a friend while continuing to walk. Despite its ubiquity, our ability to selectively stop actions is limited. Canceling one action can delay the execution of other simultaneous actions. This stopping-interference effect on continuing actions during selective stopping may be attributed to a global inhibitory mechanism with widespread effects on the motor system. Previous studies have characterized a transient global reduction in corticomotor excitability by combining brain stimulation with electromyography (EMG). Here, we examined whether global motor inhibition during selective stopping can be measured peripherally and with high temporal resolution using EMG alone. Eighteen participants performed a bimanual anticipatory response inhibition task with their index fingers while maintaining a tonic contraction of the task-irrelevant abductor digiti minimi (ADM) muscles. A time series analysis of the ADM EMG signal revealed transient inhibition during failed stopping compared with go response trials 150 to 203 ms following the stop signal. The pattern was observed in both hands during bimanual stop-all trials as well as selective stop-left and stop-right trials of either hand. These results indicate that tonic muscle activity is sensitive to the effects of global motor suppression even when stopping fails. Therefore, EMG can provide a physiological marker of global motor inhibition to probe the time course and extent of stopping processes.
The astrocytic zinc transporter ZIP12 is a synaptic protein that contributes to synaptic zinc levels in mouse auditory cortex.
Authors: Anderson Charles T. , Manning Abbey , Mendelson Benjamin Z. , Bender Philip T. R. , Ruby Rayli , Shifflett Victoria R. , Bainer Kaitlin , Dariano Donald , Webb Bradley A. , Geldenhuys Werner J.
Published: January 2025

Synaptically released zinc is a neuronal signaling system that arises from the actions of the presynaptic vesicular zinc transporter protein ZnT3. Mechanisms that regulate the actions of zinc at synapses are of great importance for many aspects of synaptic signaling in the brain. Here, we identify the astrocytic zinc transporter protein ZIP12 as a candidate mechanism that contributes to zinc clearance at cortical synapses. We identify small molecule compounds that antagonize the function of ZIP12 in heterologous expression systems, and we use one of these compounds, ZiMo12.8, to increase the concentration of ZnT3-dependent zinc at synapses in the brain of male and female mice to inhibit the activity of neuronal AMPA and NMDA glutamate receptors. These results identify a cellular mechanism and provide a pharmacological toolbox to target the molecular machinery that supports the actions of synaptic zinc in the brain.

Significance StatementSynaptic zinc is loaded into presynaptic glutamatergic vesicles by the protein zinc transporter 3 (ZnT3), where it is co-released with glutamate during synaptic transmission. Evidence from clinical studies in humans shows that alterations in the expression of the neuronal zinc transporter protein ZnT3 and the astrocytic zinc transporter protein ZIP12 are associated with schizophrenia, suggesting that dysregulation of these brain-specific zinc transporter proteins may contribute altered synaptic signaling in the brain. Our results show that ZIP12 protein is expressed by astrocytes at synapses in the brain. We identify pharmacological agents that inhibit ZIP12 and we use them to modulate zinc levels in the brain. This research advances our understanding of the roles of synaptic zinc in health and disease.
Study of Regulatory and Institutional Framework for the Relocation of the National Capital in Indonesia
Authors: Hidayat Arif , Sugiarto Laga , Sulistianingsih Dewi , Rafli Ananta Bintang , Abid A Syakur Muhammad
Published: January 2025

This study explores the regulatory and institutional framework for relocating Indonesia’s national capital (Ibu Kota Nusantara, IKN) from Jakarta to East Kalimantan, a plan rooted in the integrative ideology articulated by Soepomo in 1945. This ideology emphasizes harmony between macrocosmic and microcosmic forces within the state, suggesting that the government center should be located centrally within the country to symbolize supreme authority. The relocation is also seen as a crucial move toward achieving “Indonesia Emas 2045”. However, the enactment of Law No. 3 of 2022, which serves as the legal basis for the relocation, has faced significant criticism, particularly regarding the regulatory, institutional, and funding aspects. Previous studies have often been opinion-based and lacked scientific rigor, especially in addressing the complexities of policy implementation. This research aims to fill this gap by providing a detailed analysis of the policy from regulatory and institutional perspectives. The study uses a normative legal approach, incorporating both statute and conceptual analyses, to evaluate the regulatory and institutional frameworks guiding the capital relocation. While it does not extensively address funding issues, it focuses on identifying how well the existing rules align with the policy’s implementation goals. Findings suggest that while the relocation offers significant benefits, such as promoting national unity and symbolizing progress, the process faces challenges, including conflicts with existing regulations and institutional inefficiencies. The contribution of this study lies in offering actionable insights for both the government and civil society to assess and improve the policy’s implementation, ensuring its alignment with the broader vision of national development.
Restoration of Central Power or Betrayal of Regional Autonomy? Analysis of the Impact of Recentralization of Mining Authority in the Era of Limited Autonomy
Authors: Rijal Syamsul , Ilmar Aminuddin , Maskun Maskun , Ab Rahman Nurul Hidayat
Published: January 2025

This study analyzes the impact of re-centralizing mining authority on regional autonomy in Indonesia, focusing on legislative changes from Law No. 22/1999 to the Omnibus Law (Law No. 6/2023). The shift from decentralized to centralized control, accelerated by Law No. 3/2020, transfers authority from districts to provinces, aiming to improve national resource management efficiency. However, the findings reveal critical risks, including weakened environmental oversight, restricted public participation, and reduced local revenues from mining operations. While centralization may streamline governance, it poses significant challenges for regional governments in managing resources independently, impacting local welfare and sustainable development. This research offers novel insights into the tension between national efficiency and regional autonomy, emphasizing the urgency of re-evaluating policies to balance these interests. The study contributes to the broader discourse on governance by providing policy recommendations for achieving sustainable resource management within a decentralized framework.
Reforming Tax Law Enforcement: The Role of Core Tax Administration System Digitalization and the Ultimum Remedium Principle
Authors: Djinarto Bambang , Suhartono Slamet , Hadi Syofyan , Setyadji Sri , Nickalus Juan
Published: January 2025

This study aims to analyze the impact of the digitalization of the Core Tax Administration System (CTAS) on tax law enforcement, with a particular focus on the application of the ultimum remedium principle. The research method employed is normative legal research, involving an in-depth analysis of tax law literature, relevant regulations, and case studies of CTAS implementation. The urgency of this research lies in addressing inefficiencies, inequities, and the lack of transparency in traditional tax law enforcement through the utilization of digital technology. The findings reveal that CTAS digitalization enhances efficiency, transparency, and data management in tax administration while strengthening law enforce ment processes through improved oversight and compliance. However, this digitalization also presents challenges, including data security risks, privacy concerns, and compliance with applicable regulations. The novelty of this research lies in integrating the ultimum remedium principle within the digital framework, advocating for a proportional approach to tax violations by prioritizing voluntary compliance and corrective measures before escalating to more severe enforcement actions. This study provides strategic contributions to legal policy development, offering essential insights for policymakers, legal practitioners, and system developers in designing a tax law enforcement system that is fair, transparent, and responsive to the demands of the digital era.
OPA-IF-Neutrosophic-TOPSIS Strategy under SVNS Environment Approach and Its Application to Select the Most Effective Control Strategy for Aquaponic System
Authors: Debroy Pragnaleena , Smarandache Florentin , Majumder Priyanka , Majumdar Parijata , Seban Lalu
Published: January 2025

The accelerated progress of aquaponics offers a promising remedy for food production in arid regions, where success heavily hinges on sustaining optimal water quality parameters of aquaponic system. However, managing water parameters in large-scale aquaponic farms, given their complex and interconnected nature, poses significant challenges. Various control approaches have been introduced over the years, but selecting the most suitable one is vital for ensuring stability, efficiency, and high productivity. In this study, a novel fuzzy-based Multiple Criteria Decision Making (MCDM) methodology is proposed, which combines the Intuitionistic Fuzzy Ordinary Priority Approach (OPA-IF) with the Neutrosophic-TOPSIS strategy. This methodology aims to identify the most appropriate control strategy for large-scale aquaponic systems. The OPA-IF analysis reveals that the ‘Capability to Handle MIMO Systems’ is the most critical criterion, leading to the conclusion, through the Neutrosophic-TOPSIS approach, that ‘Model Predictive Control (MPC)’ is the optimal choice for managing large-scale aquaponic systems. Additionally, a comparative analysis using the BWM-Neutrosophic-TOPSIS strategy further supports the findings of the proposed method. The results are further validated through statistical analysis and sensitivity testing, ensuring their robustness and reliability. Overall, this study not only contributes to the scientific understanding of control strategies in aquaponics but also offers practical insights for farmers and aquaponic practitioners. The ultimate goal is to enhance the sustainability and efficiency of aquaponic systems, promoting their adoption and long-term success in sustainable food production.
The contributions of past immigration to current age-sex structures of immigrant populations in Australia
Authors: Raymer James , O’Donnell James , Guan Qing
Published: January 2025

Not all immigrant populations are the same. In this article, we decompose the age-sex structures of immigrant populations in Australia and its major cities in 2021 by periods of entry. The results show a wide array of differences among immigrant populations, as well as across major cities where the vast majority of immigrants reside. Not surprisingly, we find that immigrant groups with a longer history of immigration to Australia have a more varied age-sex profile than those with a shorter history. However, even within each immigrant group, we find substantial differences across cities that reflect the influences of policy and the preferences of the immigrants. By illustrating how historical immigration streams across areas in Australia have produced different population age-sex structures, we are able to better understand why they are different and what specific services they may require.
Az anaemia gyakoriságának felmérése, osztályozása, prediktív tényezői gyulladásos bélbetegségben szenvedő betegekben
Authors: Balogh Fruzsina , Angyal Dorottya , Ecseki Andor Áron , Sebeszta Zsófia Veronika , Gönczi Lóránt , Lontai Livia , Miheller Pál , Lakatos Péter , Iliás Ákos
Published: January 2025

Bevezetés: A vérszegénység a gyulladásos bélbetegségek egyik
leggyakoribb szövődménye és a betegség súlyosságának egyik mutatója.
Célkitűzés: Vizsgálatunk célja az anaemia gyakoriságának,
etiológiájának, prediktív tényezőinek és kezelésének felmérése volt gyulladásos
bélbetegségben szenvedő betegeket kezelő két tercier centrum
betegpopulációjában. Módszer: Retrospektív, keresztmetszeti
vizsgálatunkban egyéves időszakban (2022. 06. 01. – 2023. 05. 31.) a Semmelweis
Egyetem két klinikáján megjelent betegek körében mértük fel az anaemia
gyakoriságát, figyelembe véve az adott évben előforduló legalacsonyabb
hemoglobinértéket. Rögzítettük a demográfiai adatokat, a betegségaktivitást, a
gyógyszeres kezelést, valamint a gyulladásos markereket és a vasháztartás
laboratóriumi paramétereit. A klinikai betegségaktivitást a
Crohn-betegség-aktivitási index és a parciális Mayo-score segítségével
határoztuk meg. Az anaemia súlyossági besorolásában és osztályozásában az
Egészségügyi Világszervezet állásfoglalásait vettük alapul. Az abszolút
vashiányt <30 µg/l szérum-ferritinérték esetén, a krónikus betegségekhez
társuló anaemiát >100 µg/l ferritinérték és klinikai vagy biokémiai
betegségaktivitás jelenléte esetén definiáltuk. Eredmények:
Vizsgálatunkba 400 beteget vontunk be (Crohn-beteg/colitis ulcerosa: 277/123). A
Crohn-betegek 17,7%-a komplex (sztenotizáló/penetráló) betegségviselkedéssel,
míg a colitis ulcerosás betegek 40,7%-a extenzív vastagbél-érintettséggel volt
jellemezhető. A betegek 75%-a biológiai kezelés alatt állt. A betegpopuláció
32,5%-ában (n = 130) észleltünk anaemiát a vizsgált időszakban, melyek 57%-a
enyhe, 35%-a közepes és 8%-a súlyos fokú volt. A nem macrocytás anaemiákat (n =
116) tovább vizsgálva, a vasháztartásra vonatkozó adatok a betegek 51%-ában (n =
66) voltak elérhetők. E betegek 73%-a szenvedett vashiányos anaemiában, 6%
krónikus betegséghez társuló vérszegénységben, illetve 17% funkcionális
vashiánnyal társuló krónikus betegséggel járó anaemiában. Az anaemia prediktorai
a szteroidkezelés (p<0,001; OR: 4,2), a klinikai (p<0,001, OR: 3,8) és a
laboratóriumi betegségaktivitás (p<0,001, OR: 2,9) voltak.
Következtetés: A gyulladásos bélbetegségben szenvedő
betegek körében gyakori a vérszegénység, mely az esetek döntő többségében
vashiányos anaemia, és szoros kapcsolatban áll a betegségaktivitással. Az
anaemia felismerése, osztályozása (a vasháztartás paramétereinek vizsgálata) és
kezelése kiemelten fontos a gyulladásos bélbetegségben szenvedők körében. Orv
Hetil. 2025; 166(2): 60–66.
Abszcizinsav – táplálkozási lánc és humán egészség
Authors: Blázovics Anna
Published: January 2025

Az abszcizinsav egy ősi, a törzsfejlődés különböző szintjein jelen lévő, az
élőlények környezethez való alkalmazkodását elősegítő univerzális izoprenoid
vegyület. Az 1940-es években figyeltek fel először a növények növekedését gátló
anyagra, amelyről az 1960-as évek közepén kiderült, hogy a növények nyugalmi
állapotát szabályozó fitohormon. A 2010-es években végzett kutatások feltárták
az abszcizinsav bioszintézisét. A mevalonsavból mint kiindulási vegyületből
szintetizálódó xantofillok lebomlásának terméke a bioaktív abszcizinsav, egy
oxigénben gazdag diterpén molekula. Az abszcizinsav mint másodlagos
anyagcseretermék a növények számos élettani folyamatát befolyásolja. Az utóbbi
két évtizedben molekuláris-genetikai, biokémiai és farmakológiai tanulmányokat
végezve felderítették az abszcizinsav univerzális jelátviteli útvonalát. Az e
vizsgálatokkal párhuzamosan végzett állatkísérletek során 1986-ban arra a
felismerésre jutottak, hogy az abszcizinsav az állati szervezetben is
termelődik. Az ezredfordulót követően egyre többen érdeklődtek az abszcizinsav
állati szervekben, szövetekben, sejtekben (leukocyták, monocyták/makrofágok,
granulocyták, microgliasejtek, hasnyálmirigysejtek, mesenchymalis őssejtek stb.)
betöltött szerepe iránt. Mára már hatalmas irodalma van e vegyület sokoldalú
élettani hatásának. Bizonyítottan humán endogén hormon. Az abszcizinsav mind az
állatokban, mind az emberben számos élettani funkciót a növényekben megismert
jelátviteli útvonalhoz nagyon hasonló módon szabályoz, így a sejtek növekedését,
fejlődését és a különböző ingerekre adott immunválaszokat. Ismertté vált az is,
hogy az abszcizinsav növekedésszabályozóként az állati szervezet számára nem
toxikus, ugyanakkor gátolja a rákos sejtek növekedését. Kedvezően befolyásolja a
szénhidrát-anyagcserét, valamint gyulladásgátló tulajdonsággal is rendelkezik,
de leírták gyulladásfokozó hatását is. Jelenleg humán gyógyászati alkalmazásának
lehetőségét kutatják. Orv Hetil. 2025; 166(2): 43–49.
Classical Islamic philosophy and the gendered perfection of bodies and minds
Authors: Von Doetinchem de Rande Raissa A
Published: January 2025

How does classical Islamic philosophy envisage political leadership? Many – scholars and popular commentators alike – assume that, in line with certain Qur’anic and social commitments regarding gender roles, the Islamic political tradition is, and always has been, unenthusiastic about female political leadership. Examining the works of three important political thinkers – al-Farabi (d. 950), Ibn Tufayl (d. 1185), and Ibn Rushd (d. 1198) – this article complicates a simplistic vision. I will show that both on the issue of whether only the most perfect are capable of leadership and the question of whether women, too, can be such leaders, classical thinkers diverge and thus elude a simplistic assessment of the premodern tradition. My foray into classical Islamic discourses on political leadership will thus end by emphasizing caution. We must be wary of any attempts to draw straightforward connections between contemporary grievances and the classical tradition of Islamic political thought, as well as be attentive to the breadth and contestation of basic commitments among different figures.
The inviolability and value of the human body and the corpse in the Islamic legal tradition
Authors: Lee Dana
Published: January 2025

This article examines how the inviolability (hurma) of the human body is conceived of and negotiated within juristic discourses on the paradigmatic hypothetical case of the starving person from the fifth/eleventh through seventh/thirteenth centuries. The Islamic legal tradition documents lively juristic discussions and debates on hypothetical cases of necessity, many of which implicate foundational questions of value and the inviolability of the human body. At a basic level, necessity applies to a situation in which someone must ‘break’ the law or fail to fulfill a legal obligation, in order to escape the threat of serious harm to something of high value (usually, life, limb, or health). The jurists constructed multiple hypothetical cases of necessity that implicate the inviolability of the human body, including the cases of the starving person, excision of gangrenous tissue, and cesarian section, as well as numerous fact patterns of coercion. This article considers the challenging issues of inflicting serious bodily harm on others and on oneself in order to preserve life, including inflicting harm on the living and on the dead, as well as self-harm. It provides an account and analysis of both the substance and mechanics of fiqh argument, or how jurists reasoned through complex questions of value that also have substantial bases  in conceptions of the human body, medicine, logic, and reasonableness through the language and method of the fiqh. This article argues that the evidence and methods of argumentation employed by the jurists reveal significant diversity and tensions in juristic method and understandings of value and subjectivity in the fiqh, as well as in the construction of the foundational concepts of inviolability (hurma) and (legal) protection ('isma). Furthermore, it shows that in the starving person paradigm, the jurists explored the boundary between (non-human) animality and humanity, and grappled with how to locate the (dead) human body within legal thought, and how to operationalize the higher degree of respect accorded to the human body than to non-human bodies. Finally, it examines the ways in which these discourses provide material for considering the functions of subjectivity, emotions, and moral aversion in the law.
Navigating Loss and Existential Anguish in Social Media: Religious Strife and Grief in the Israeli-Palestinian Conflict
Authors: Wawaysadhya Wawaysadhya , Chair Badrul Munir , Oktafiani Tri Utami
Published: January 2025

Conflict and war give rise to grief and feelings of loss experi­enced by the victims. This feeling of grief and loss is no exception in the conflict between Israel and Palestine. The prolonged warfare results in anxiety about death and raises concerns about the uncertain fate of hu­manity. This research elucidates how religious beliefs alleviate the anxiety about death and cope with the grief caused by conflict and war. Ques­tions addressed in this study explore the influence of religious beliefs to­wards the perceptions of death, the helplessness of life, and existential efforts against the sorrow of loss. The researcher examines consistent social media accounts expressing the impact of the Israel-Palestine con­flict, namely the Instagram accounts Eye on Palestine (@eye.on.palestine), Gaza journalist Motaz Azaiza (@motaz_azaiza), and another Gaza jour­nalist Anas Ali Al-Syarif (@anasjamal44). The findings of this research indicate that religious beliefs can alleviate death anxiety, aid in coping with loss, and enhance acceptance of destiny. Through religious tenets, death due to war is interpreted as martyrdom, thus fostering optimism in accepting fate. Furthermore, religious beliefs impact a strong belief in positive compensation in the afterlife, giving rise to a narrative of opti­mism in navigating life amid the turmoil of war.
Emergency care in cross-border settings: a scoping review
Authors: Rodríguez Dennise , Pilot Eva , Krafft Thomas , Gurgel Helen
Published: January 2025

Emergency Medical Services (EMS) have developed from a war context into a complex scenario of rapid urbanization and great interconnectivity, which includes cross-border areas. Specificities of these areas are underrepresented in studies about EMS. The aim of this work is to provide a better comprehension of emergency care in cross-border settings. A qualitative scoping review was performed in three major databases of interest, where 29 works matched the inclusion strategy and underwent thematic analysis. Results show a consistent growing interest in this topic, even though the term ‘cross-border’ remains as a multidisciplinary approach with lack of clarity in its definition. These studies are more frequent in the European Union due to the ‘borderless’ discourse and practices, and in other specific cases, such as the US-Mexico border, building a dominant perspective from the Global North. Frequent challenges that cross-border EMS face are linguistic and sociocultural barriers, high complexity in the legal and institutional framework, financial issues, lack of standardization in recognition of professional skills, lack of interoperability of cross-border data, problems in emergency communication and missing consensus in concepts and practices. Despite all these difficulties, multiple advantages are perceived and documented, as better patient and social outcomes, increased efficiency on the utilization and management of resources, reduction on delayed responses and undertreatment, better quality of the provided services, higher patient satisfaction, creation of synergies of shared responsibilities in border areas which are usually perceived as peripheral and improvement in public health preparedness and emergency responses.
Diagnostic Power of the CD4+/CD8+ Ratio and the Expression of Activation and Memory Markers in Differentiating Sarcoidosis from Tuberculosis, Idiopathic Pulmonary Fibrosis, and Other Interstitial Lung Diseases
Authors: El Fakihi Sara , El Allam Aicha , Tahoune Hicham , Kadi Chaimae , Ibrahimi Azeddine , Bourkadi Jamal-Eddine , Seghrouchni Fouad
Published: January 2025

Background: Sarcoidosis is a complex inflammatory disease of unknown etiology affecting mostly the lungs and poses a significant diagnostic challenge, particularly in regions where tuberculosis (TB) is endemic. The diagnostic complexity intensifies due to shared clinical and radiological features between sarcoidosis and TB, as well as similarities with idiopathic pulmonary fibrosis (IPF) in cases that progress to pulmonary fibrosis. Accurately distinguishing between these diseases is critical for timely and effective patient management.
Objective: This study breaks new ground by evaluating the diagnostic power of the bronchoalveolar lavage (BAL) CD4/ CD8 ratio, along with key activation and memory markers to differentiate sarcoidosis from TB, IPF, and other-interstitial lung diseases (ILDs).
Methods: A cohort of 68 patients with ILDs, including sarcoidosis (n = 37), TB (n = 19), IPF (n = 6), and Other-ILDs (n =
6) were assessed. The CD4/CD8 ratio and a panel of activation and memory markers were analyzed through flow cytometry.
Results: Sarcoidosis exhibited a significantly higher CD4/CD8 ratio compared to those with TB, IPF, and Other-ILDs. An optimal cutoff value of 3.7 for the CD4/CD8 ratio in sarcoidosis with an area under the ROC curve (AUC) of 0.7%, had a specificity of 96.8%, and a sensitivity of 43.2%. In addition, a significant difference was detected in CD38, CD45RA, CD45RO, and CD62L expression.
Conclusion: Combining the CD4/CD8 ratio (> 3.7) with the expression of CD38, CD62L, and memory markers is a promising new tool for the differential diagnosis of sarcoidosis.
Construcción conceptual en física a través de métodos didácticos inductivos
Authors: Cuevas Romo Julio
Published: January 2025

This contribution shows the development and evaluation of an educational process withmathematics teachers in training, focused on the use of teaching strategies with inductive characteristics, in Mathematics and Physics subject of the Bachelor’s Degree in Mathematics Teaching at the University of Colima, Mexico. The experience includes 19 students, who have had disciplinary training in mathematics and master the procedural knowledge and algebraic language involved in Physics at the basic levels, but they had had little access to conceptual knowledge of both classical physics and modern physics. With this principle, the course focused on reflection and problem solving. From this logic, the proposal included searching for both the procedural and conceptualdomain, this second one is the central objective of this research. The inductive methods included theuse of audiovisual materials and readings, that go more in the order of dissemination. The results of their work show that, without omitting a more traditional training process, such as problem-solving or classic physics textbooks, the incorporation of inductive strategies focused on the particularities of concepts like “motion” or “light” allows for a deeper understanding of fundamental principles,serving as a functional complement for a more comprehensive understanding.
El desafío de la escritura académica utilizando herramientas virtuales
Authors: Simbaña Gallardo Verónica Patricia , Jaramillo Naranjo Lilian Mercedes , Vinueza Vinueza Santiago Fernando
Published: January 2025

Technologies are inserted in educational innovation, giving the possibility of incorporatingdigital tools in research approaches. In this scenario, Scrivener and Evernote are digital tools for academic writing; they allow you to insert written notes, voice notes, summaries, documents,images, quotes from authors, audios, links, among others. The formulation of the problem is based on the need to increase research at all educational levels in an easy and automated way. The objective of this study is to reflect on the significant contribution that virtual tools have in academic writing. The methodology used is framed within the qualitative paradigm of a non-experimentaland documentary type, it has an intentional probabilistic sampling of 57 primary documentarysources that consist of scientific articles, books, official sources, technical reports, authors andorganizations that support the theories of the tools. digital to scientifically support the article.The conclusion is that the Scrivener and Evernote tools generate a significant contribution to thedevelopment of academic writing, contributing to the promotion of the publication of academicand scientific articles, which associated with information and communication technologiespromote the development of this type. of research communities, to achieve greater optimization ofintellectual resources as a challenge to enhance academic culture.
Türkiye’de Su Tüketiminin Sürdürülebilirliğinin Çevresel Kuznets Eğrisi Hipotezi Kapsamında Değerlendirilmesi
Authors: Göde Bilal , Karayılmazlar Ekrem
Published: January 2025

Bir doğal kaynak olan suya, ekonomik gelişimle beraber talep artmaktadır. Bölgesel olarak farklı dağılması nedeniyle suya herkesin eşit olarak erişimi zorlaşmaktadır. Ekonomik faaliyetlerin büyüdüğü yerler olan büyükşehirler cazibe merkezleri olmakta ve nüfusları artmaktadır. Çalışmada Türkiye için 1992-2019 yılları arasındaki kişi başı toplam su tüketimi ile kişi başı GSYH ve şehir nüfusu arasındaki ilişki Çevresel Kuznets Eğrisi Hipotezi kapsamında araştırılmıştır. Modelde Johansen eşbütünleşme testi uygulanmış ve değişkenler arasında eşbütünleşmenin olduğu sonucuna ulaşılmıştır. CCR, FMOLS ve DOLS testlerinin uygulanması sonucunda ÇKE hipotezinin Türkiye’de geçerli olmadığı sonucuna ulaşılmıştır. ÇKE eğrisi model sonucuna göre U şeklinde oluşmuştur.
Yükselen Yapay Zekâ Devrimi: İstihdam ve Verimlilik Üzerine Etkisi
Authors: Tekin Balcı Ayşe , Demirel Onur
Published: January 2025

İktisadi hayatın çoğu alanında geleneksel sektörler yerini dijitalleşmeye bırakmaktadır. Yapay zekâ teknolojilerinin geleceğe damga vurması beklenmektedir. Çalışmada, yapay zekânın istihdam ve verimlilik üzerindeki etkisi ilgili teknolojileri en çok kullanan 10 ülke için 2002-2021 dönemi panel verisi ve Vektör Hata Düzeltme Modeli, eşbütünleşme, Granger ve Toda-Yamamoto nedensellik testleri kullanılarak gerçekleştirilmiştir. Analiz sonucunda yapay zekâ teknolojilerini temsil eden patent başvuruları, Ar-Ge harcamaları, yüksek teknolojili ürün ihracatı ile istihdam ve verimlilik arasında uzun dönemli pozitif ilişki tespit edilmiş olup Toda-Yamamoto nedensellik test sonuçlarına göre yapay zekâ teknolojilerini temsil eden vekil değişkenler ile istihdam ve verimlilik arasında çok yönlü nedensellik ilişkisinin olduğu sonucuna varılmıştır.
Vergi Okuryazarlığı Ölçeğinin Geliştirilmesi: Geçerlik ve Güvenirlik Çalışması
Authors: Öksüz Mehmet , Doğan İbrahim Ali Cem
Published: January 2025

Vergi okuryazarlığı olgusu temelde bireylerin verginin temel özelliklerini bilmesine, vergi kanunlarını anlamasına ve vergi risklerini bağımsız olarak değerlendirebilmesine dayanmaktadır. Bu kapsamda çalışmanın amacı, vergi okuryazarlığı olgusunun yalnızca temel özelliklerini içeren, uygulanması pratik, geçerliği ve güvenirliği kanıtlanmış bir vergi okuryazarlığı ölçeği geliştirilmesidir. Bu amaç doğrultusunda uzman görüşleri alınarak ölçeğin kapsam geçerliği, Açımlayıcı Faktör Analizi kullanılarak da yapı geçerliği sağlanmıştır. Yapılan analizler sonucunda 3 faktörlü 14 maddeden oluşan bir vergi okuryazarlığı ölçeği oluşturulmuş ve bu ölçek aynı zamanda Doğrulayıcı Faktör Analizi ile de doğrulanmıştır.
Türkiye’de Kamu Borç Yükü ile Gelir Dağılımı İlişkisi: ARDL Sınır Testi Yaklaşımı
Authors: Bayraktar Daştan Ceyda
Published: January 2025

Bu çalışmanın amacı, Türkiye’de kamu borç yükü ve gelir dağılımı ilişkisini 1989-2023 dönemi için yıllık veri seti kullanarak analiz etmektir. İki farklı model eşliğinde yürütülen araştırmada değişkenler arasındaki eşbütünleşme ilişkisinin incelenmesinde ARDL Sınır Testi yaklaşımı, nedenselliğin incelenmesinde ise Toda-Yamamoto yöntemi kullanılmıştır. Analizde, uzun dönem katsayılarının değerlendirilmesinde DOLS ve FMOLS yöntemlerinden yararlanılmıştır. Analiz sonuçları, dış borç stoku/GSYH oranında ve özellikle kamu sektörü dış borç yükündeki artışın gelir dağılımında eşitliği bozucu etki meydana getirdiğini ortaya koymaktadır. Türkiye’de gelir eşitsizliğinin giderilebilmesi için söz konusu değişkenlerin GSYH’ya oranında azalış meydana getirecek politika kararlarının etkili olabileceği yönünde değerlendirmede bulunulabilir.
The Project of the Last War for Peace: Philosophical Sighs
Authors:   Institute for Philosophy and Social Theory, University of Belgrade, Serbia, Bojanić Petar ,   Ural Federal University (UrFU), Ekaterinburg, Russia
Published: January 2025

The article examines Johann Gottlieb Fichte’s concept of the “closed commercial
state” and his views on war and borders. The author analyzes Fichte’s use of the term
“natural borders” and its role in legitimizing state consolidation through warfare. The
paper explores Fichte’s argument that philosophers have historically “sighed over
wars” and his assertion that war is inevitable in the current state of affairs. Fichte
proposes that to abolish war, its root cause must be eliminated by allowing each state
to obtain its natural borders. The author delves into Fichte’s notion of the “closed
commercial state” and how it relates to the idea of natural borders. Fichte envisions
this state as self-sufficient and detached from others, with clearly defined boundaries.
The concept of “internal borders” is also discussed as a means to surpass and replace
natural borders.
The paper examines Fichte’s justification for a “final war” that would end all future
wars by establishing natural borders. The author critiques the logic of this argument,
noting that it could potentially lead to a global conflict. Fichte’s attempt to make this
final war as peaceful as possible is analyzed, including his idea of an “occupation
march” rather than a bloody conflict. The author argues that this conception relies
on negating the existence of the “other” state. Finally, the article discusses Fichte’s
view on commercial warfare and its relation to territorial conflicts. The author concludes
by reflecting on how Fichte’s project of a closed state ultimately turns inward,
negating the very concept of borders as interfaces with others.
Analytic Philosophy: Has It Finally Been Defined?
Authors:   Institute of Philosophy, Russian Academy of Sciences (RAS), Moscow, Russia, Shokhin Vladimir
Published: January 2025

While analytical philosophy remains the main format of academic philosophizing in Great Britain and the USA, wining ground on the European continent and in the Third World countries, its comprehension as a cultural phenomenon falls far behind the scale of its spread even at the level of identification. The article examines solution to this problem suggested by Hans-Johann Glock — one of the most eminent historians of analytic philosophy, who sets the parameters for discussing the subject within the framework of contemporary metaphilosophy. The author highlights Glock’s step-type repudiation of accepted identifications of analytic philosophy (from the geographical to ideological ones) and his offer of his own, i.e. via “family resemblances” and “family ties” within it, and criticizes it as both consensual and contradictory from the methodological point of view.
In return, the author of the article offers an alternative interpretation of the same phenomenon as a very traditional investigative-cum-controversial practice, very distant from being “revolutionary,” i.e. contrary to the non-rational belief of its numerous apologists stubbornly marketing it as a modern philosophical school dating from Bertrand Russell, George Edward Moore, and Ludwig Wittgenstein (sometimes also from Gottlob Frege). The practice under discussion cannot be typologically separated from the centuries-old intercultural scholasticism (the term being used by the author without any pejorative accent) in whose history the activity of the aforementioned persons can be seen as truly seminal but by no means ground-breaking. Attention is paid also to such effects which are conditioned by appropriation analytic philosophy by one of the Russian publishers working unalterably with the same translators.
Marquis de Sade — the Inventor of the Interface
Authors:   National Research University Higher School of Economics (HSE University), Ocheretyany Konstantin ,   St. Petersburg State University (SPbU)
Published: January 2025

The article analyzes the user interface as a condition of presence in digital reality. It
is shown that the interface in the unity of linguistic practices, desire apparatuses and
social institutions is closer to forms of life than to formal systems. Therefore, based
on a rational and technological approach to the interface, its capabilities, functions
and limitations, it is necessary to recognize and describe the myth that determines
the way of existence in the interface. It is a common belief that a myth suggested by
a digital interface was inspired by Jean-Jacques Rousseau and could be described in
terms of the social establishment, the perfect language, the optimum of government.
It is shown that we only imagine to be living in a Rousseau’s mythopoeic scenario
while supporting and affirming with our actions and behavior a completely different
one — quite far in its intentions from the first one (and just at the moment when we
think that we are pursuing that first one). Thus, a number of epistemic distortions
and contradictions make it clear that the forms of logic and pragmatics, which the
interface prescribes to forms of digital behavior and interaction, are closer to the
hallucinatory-autoerotic narrative machines created by Marquis de Sade than to
Rousseau’s utopian myth. We always find Sade where we most aspire to Rousseau.
To give Sade the voice as the inventor of the interface means to show that the
antinomianism found at the heart of digital interaction is the product of the struggle
between two views on utopia: formally-roussoistic one and another one — actorsadistic,
one of which is invariably hypostatized and another one is usually ignored.
Populating metadata templates for NCBI submissions using PulseNet 2.0 v2
Authors: Timme Ruth , Balkey Maria , Pfefer Tina , Hope Bias Candace
Published: January 2025

PURPOSE: to define the standard operating procedure for collecting isolate metadata using PulseNet 2.0 for submission of food/environmental isolates to NCBI. SCOPE: to provide a standardized procedure to collect isolate metadata using PulseNet 2.0 for submission of food/environmental isolates to NCBI. RESPONSIBILITIES- SOP Responsible Officials: Ruth Timme, Maria Balkey The GenomeTrakr Network Management will be responsible to monitor GenomeTrakr submissions processed through PulseNet 2.0 and ensure that all GT labs are familiar with the mandatory metadata fields required for submission of GenomeTrakr sequencing records to NCBI. V3: Added dropdown menus from controlled vocabulary to sequenced by and project name to metadata template PulseNet_Bionumerics_Isolate_Metadata V4: Changes in metadata template PulseNet_Bionumerics_Isolate_Metadata. - Added dropdown menus from controlled vocabulary to collected_by , SourceCountryState - Added fields: collected by, isolation source - Added mapping table of attribute names. - Remove requirement to send biosample update to NCBI to make changes on sequenced by and project name. V5: Changes implemented to handle NCBI submissions for GenomeTrakr through the PulseNet 2.0 platform. V6: New version of spreadsheet with updated dropdown menu. Add values to NCBI Templates V7: Add GMVS option to download metadata spreadsheet. Mapping serovar to serotype_wgs or serotype.
HNOE_15N_HSQC.nan v1
Authors: KB NAN
Published: January 2025

This protocol describes running a Pseudo-3D 15N {1H} HNOE HSQC experiment with sensitivity enhancement, gradient coherence selection, water flip-back, and optional 13C decoupling. Two datasets, reference and saturation, are acquired as a single pseudo-3D experiment, with TD1 fixed at 2. Both saturation delay and reference delay are determined internally from D1 delay. 15N labeling is required; can also be applied to proteins with additional 13C and 2H labeling. It uses the Topspin library pulseprogram 'hsqcnoef3gpsi3d'.
Open Field v1
Authors: Adamson Ashley , Smith Allie , R De Miranda Briana
Published: January 2025

The following protocol is used to assess gross motor and anxiety-related behaviors using the Open Field Test at the University of Alabama at Birmingham's Neuroscience Behavioral Assessment Core.
INDICATORS AND CALCULATION PARAMETERS IN THE ASSESSMENT OF ECOSYSTEM SERVICES FOR BIODIVERSITY CONSERVATION
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, KOROHODA Nataliia
Published: January 2025

Background. The concept of ecosystem services (ES) is closely related to the concept of biodiversity conservation. Urban green spaces (UGS) are areas of importance for urban biodiversity conservation. UGSs can effectively provide biodiversity services if they form an ecological network. The issue of assessing ecosystem services for biodiversity conservation in cities, where the assessment of ES is based on the "ecological network" approach, is currently not sufficiently covered. The development of a set of assessment indicators, calculation parameters, and a methodology for assessing ecosystem services for biodiversity conservation in the city has become the goal of this work.

Methods. In this paper, we have developed an assessment methodology based on determining the effectiveness of the UGSs performance of "eco-network" functions. Differences in the indicators of biodiversity conservation are caused by a number of factors. The natural factors include the presence of rare and endangered species within the UGS; landscape diversity; metric and qualitative characteristics of green spaces. Anthropogenic factors include the degree of landscape transformation.

Results. Accordingly, these factors have become indicators for assessing: biopopulation, landscape diversity, nature conservation, territorial, phase-anthropisation and phase-ethological sustainability. The calculated parameters are: biopopulation potential indicator, integral indicator of landscape diversity, indicator of conservation status, sufficient dimensionality, phase- anthropisation sustainability index, etc. These parameters make it possible to implement the assessment methodology at two territorial levels (citywide and local) and determine the effectiveness of the urban blue-green infrastructure (BGI) or a particular UGS in performing the biodiversity conservation function. The effectiveness of UGS s is determined depending on their condition. At the city-wide level, the effectiveness is determined through the interconnectedness of the elements of the GIS.

Conclusions. Effectiveness indicators, based on the Harrington's desirability function, allow to establish the scope of biodiversity conservation ES. The assessment based on this methodology can be a useful tool in urban planning decision-making, as it allows identifying green spaces that require priority action to create conditions for biodiversity conservation.
Evaluating Localization Accuracy of Dynamic Binaural Synthesis: Differences Between Individual, Estimated, and Generic HRTFs
Authors: Frankenbach Cornelius , Herzog Carsten , Seitz Julia , Fels Janina
Published: January 2025

In a listening experiment with 24 participants, the localization accuracy of dynamic binaural synthesis employing individual and estimated head-related transfer functions (HRTFs) was compared to the localization accuracy with generic HRTFs in vertical and horizontal direction. The experiment featured five different HRTF estimation methods, high-frequency audiometry, proximal pointing, and individual headphone equalization. While generic Knowles Electronics Mannikin for Acoustic Research (KEMAR) HRTFs served as a baseline, individually measured ones provided a reference. Estimated HRTFs were acquired based on anthropometric data and 3D head models by means of an interaural time difference adaptation, a selection from an HRTF database, a principal component-based synthesis, and a numerical HRTF simulation. Compared to the KEMAR, measured and estimated HRTFs produced significantly smaller vertical errors, while differences in terms of the horizontal error were not significant. The HRTF synthesis qualified as the preferred estimation method by significantly reducing the vertical error for virtual sources on and below the horizontal plane, compared to the generic HRTFs.
Cerebral edema and cognitive dysfunction: pathophysiological interconnections in diabetic ketoacidosis in childhood
Authors: Bykov Yuri V.
Published: January 2025

Diabetic ketoacidosis is one of the most common complications in children suffering from diabetes mellitus, a complication that may cause cerebral edema. After a diabetic ketoacidosis episode, some children develop cognitive impairment, which could be linked to subclinical or clinical grade cerebral edema. An analysis of scientific literature has shown that the pathophysiological mechanisms of the development of cognitive dysfunction in children with diabetic ketoacidosis-associated cerebral edema have not been fully elucidated. The key pathogenetic hypotheses under consideration include hypoxia, cerebral hypoperfusion and reperfusion, release of vasoactive substances and induction of inflammation, acute hyperglycemia and oxidative stress. Hypoxia leads to hypoxic-ischaemic injury of the brain, affecting, among others, areas responsible for memory formation. Cerebral hypoperfusion and reperfusion trigger mitochondrial dysfunction and oxidative stress, which worsens the cognitive impairment in patients with cerebral edema. Release of vasoactive substances and induction of inflammation impair the functioning of the blood-brain barrier and lead to cerebral vasospasm. Acute hypoglycemia triggers the development of brain tissue acidosis and accumulation of lactate and glutamate, aggravating the cognitive dysfunction. Oxidative stress causes neuronal damage, exacerbating the manifestations of cerebral edema. The pathophysiological mechanisms described here may cause cognitive dysfunction in the setting of cerebral edema either as individual triggers or collectively through a synergistic effect. Further research is needed to expand the knowledge of pathophysiological interconnections between cognitive dysfunction and cerebral edema in children after a diabetic ketoacidosis episode.