Primary results of the brazilian registry of atherothrombotic disease (NEAT)
Authors: de Barros e Silva Pedro G. M. , do Nascimento Charlene Troiani , Pedrosa Rodrigo Pinto , Nakazone Marcelo Arruda , do Nascimento Michel Ulloffo , de Araújo Melo Leiliandry , Júnior Osvaldo Lourenço Silva , Zimmermann Sérgio Luiz , de Melo Rodrigo Morel Vieira , Bergo Ricardo Reinaldo , Precoma Dalton Bertolim , Tramujas Lucas , Lima Eduardo Gomes , Dantas João Miguel Malta , do Amaral Baruzzi Antônio Cláudio , Flumignan Ronald Luiz Gomes , de Oliveira Paiva Maria Sanali Moura , Gowdak Luís Henrique Wolff , de Carvalho Priscila Nasser , de Figueiredo Neto José Albuquerque , Silvestre Odilson Marcos , Fioranelli Alexandre , Vieira Ricardo D.’Oliveira , Horak Ana Clara Peneluppi , Miyada Debora Harumi Kodama , Kojima Flávia Cristina Soares , de Oliveira Júlia Souza , de Oliveira Silva Leila , Pavanello Ricardo , Ramacciotti Eduardo , Lopes Renato D. ,   the NEAT Investigators, do Nascimento Charlene Troiani , Pedrosa Rodrigo Pinto , Nakazone Marcelo Arruda , do Nascimento Michel Ulloffo , de Araújo Melo Leiliandry , Júnior Osvaldo Lourenço Silva , Zimmermann Sérgio Luiz , de Melo Rodrigo Morel Vieira , Bergo Ricardo Reinaldo , Precoma Dalton Bertolim , Tramujas Lucas , Lima Eduardo Gomes , Dantas João Miguel Malta , do Amaral Baruzzi Antônio Cláudio , Flumignan Ronald Luiz Gomes , de Oliveira Paiva Maria Sanali Moura , Gowdak Luís Henrique Wolff , de Carvalho Priscila Nasser , de Figueiredo Neto José Albuquerque , Silvestre Odilson Marcos , Fioranelli Alexandre , Vieira Ricardo D.’Oliveira , Fortes José Augusto Ribas , Ritt Luiz Eduardo Fonteles , Requião-Moura Lúcio R. , Borges Fabricio Assami , Bernoche Claudia , Pompilio Mauricio Antonio 
Published: February 2024

There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease. From the total of patients enrolled, 2 were excluded since they did not meet eligibility criteria. Among the 2,003 subjects included in the analysis, 55.6% had isolated CAD, 28.7% exclusive PAD and 15.7% had both diagnoses. Overall mean age was 66.3 (± 10.5) years and 65.7% were male patients. Regarding evidence-based therapies (EBTs), 4% were not using any antithrombotic drug and only 1.5% were using vascular dose of rivaroxaban (2.5 mg bid). Only 0.3% of the patients satisfied all the domains of secondary prevention, including prescription of EBTs and targets of body-mass index, blood pressure, LDL-cholesterol, and adherence of lifestyle recommendations. The main barrier for prescription of EBTs was medical judgement. Our findings highlight that the contemporary practice does not reflect a comprehensive approach for secondary prevention and had very low incorporation of new therapies in Brazil. Large-scale populational interventions addressing these gaps are warranted to improve the use of evidence-based therapies and reduce the burden of atherothrombotic disease.

ClinicalTrials.gov NCT04677725