bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytochemical Evaluation of Extracts and Pharmacological Activity of Polyherbal Emulgel
Authors: Kandale Jitendra , Sangshetti Jaiprakash , Mahaparale Paresh , Dama Ganesh , Bidkar Jayant
Published: July 2023

Ocimum sanctum, Rubia cordifolia, Glycyrrhiza glabra, and Punica granatum are all used to treat various diseases and conditions in Ayurvedic medicine. In this study, we aimed to formulate and evaluate a polyherbal emulgel containing extracts from four different medicinal plants: O. sanctum, R. cordifolia, G. glabra, and P. granatum. Different gel formulations were created by combining a base component with extracts from O. sanctum, R. cordifolia, G. glabra, and P. granatum. pH, viscosity, rheology, appearance, and homogeneity were some of the criteria examined for each formulation. They were tested for evaporation and irritation of the epidermis with patches. The cup plate method was used to examine the antibacterial-antifungal activity of formulations against Escherichia coli, Pseudomonas aeruginosa, and Aspergillus niger. Results showed that the inhibition zones produced by all formulations were greater than those produced by the control. Antimicrobial characteristics can be found in polyherbal gels. Synergy between the plant components in the blend produced the desirable outcome.
Formulation and In-vitro Evaluation of Bilayer Tablet of Olmesartan Medoxomil for Biphasic Drug Release
Authors: Parashar Tarun , Kalra Kapil , Kalra Jyoti M. , Singh Nishan , Saha Supriyo , Singh Alka , Morris Sristhi , Jakhmola Vikash
Published: July 2023

Objective: The current study aimed to optimize the bioavailability and absorption of olmesartan in the lower gastrointestinal tract by creating a bilayer tablet for biphasic drug release. Methods: Microcrystalline cellulose was combined and direct compression the requirement for an early response to address an undesirable defect or condition. In the current instance, 5 mg of olmesartan must be released immediately, and the remaining 10 mg of olmesartan must be released gradually to maintain the therapeutic concentration. In order to adjust the release pattern of the olmesartan sustained release tablet in accordance with the needs of therapy and IP guidelines. Result: The best cumulative drug release was demonstrated by formulation. All formulations for immediate release support the first-order kinetics. As a result, all three formulations were chosen for additional research. Dissolution rate for long-term release Cumulative drug release from the SR1 to SR3 formulations using HPMC K15M and gum acacia was up to 24 hours. Utilizing HPMC K15M and guar gum, the formulations SR1, SR2, and SR3 demonstrated cumulative drug releases of 72.66, 69.19, and 92.66%, respectively. The best cumulative release of the drug was demonstrated by formulations SR1, SR2, and SR3. Consequently, everyone was chosen for additional research. The cumulative drug release for the IR1-SR1, IR2-SR2, and IR3-SR3 bilayer tablet formulations was 95.24, 90.15, and 91.09%. Up to 12 hours of cumulative drug release from the formulation was observed. As a result, it was determined that IR1-SR1 was the best formulation out of all of them due to its strong correlation between the total cumulative percentage of medication releases and time, which was 95.24% up to 12 hours.
Data Integrity Violations in the Pharmaceutical Industry and Regulatory Measures
Authors: Ingale M H , Tayade M C , Patil Y P , Salunkhe Rahul
Published: July 2023

Data integrity is critical to the pharmaceutical industry, ensuring the reliability, accuracy, and consistency of data generated throughout the product lifecycle. However, data integrity violations have been a growing concern, potentially compromising pharmaceutical products’ safety, efficacy, and quality. This systematic review aims to provide an overview of data integrity violations in the pharmaceutical industry and examine the regulatory measures implemented to address this issue. Through a comprehensive analysis of literature, this review highlights the root causes of data integrity violations, the impact on patient safety and public health, and the regulatory landscape governing data integrity in the pharmaceutical industry. It is essential for pharmaceutical companies to prioritize data integrity as an integral part of their operations, from research and development to manufacturing, clinical trials, and post-marketing surveillance. By implementing robust data integrity practices and adhering to regulatory requirements, pharmaceutical companies can protect patient welfare, maintain regulatory compliance, and sustain public trust in the industry.
Lopcow ve Cradis yöntemleriyle G7 ülkelerinin ve Türkiye’nin yaşanabilir güç merkezi şehirlerinin değerlendirilmesi
Authors: KELEŞ Nuh
Published: July 2023

Dünya üzerinde yüzyıl öncekinden farklı olarak insanlar günümüzde artık kentlerde ve bundan daha fazlasını isteyerek daha büyük şehirlerde yaşamaktadır. Şehirler sadece ekonomik açıdan veya nüfus büyüklüğü açısından değil aynı zamanda insanlara sundukları yaşam kalitesi açısından da öne çıktıklarında dünya üzerinde daha önemli bir yer tutabilirler. Bu çalışma küresel ekonomik güçlerin bir araya geldiği G7 ülkeleri ve Türkiye’nin yaşanabilir güç merkezi şehirlerinin değerlendirilmesinde yeni bir ağırlık bulma yöntemi olan LOPCOW yönteminin ve yeni bir sıralama yöntemi olan CRADIS yönteminin kullanılmasını amaçlamıştır. 3 farklı karar matrisine göre kriterler LOPCOW yöntemiyle değerlendirilmiş, birleştirilmiş değerlendirmede 14 kriter arasından C7-Satın Alma Gücü kriteri %11,3 ağırlıkla ilk sırada bulunmuştur. LOPCOW yönteminin Entropy, CRITIC ve MEREC yöntemleriyle karşılaştırılmasında yüksek varyasyonlarla baş edebildiği ve kriterlerin en önemli ve daha az önemli olanları arasındaki farkı daha makul düzeyde bulduğu görülmüştür. CRADIS yöntemiyle 15 alternatifin değerlendirilmesinde Tokyo, New York, Londra, Frankfurt, Chicago ilk 5 sırada, son sırada ise İstanbul bulunmuştur. CRADIS yönteminin EDAS, COPRAS, MOORA, CODAS, OCRA, ROV, ARAS, MARCOS ve TOPSIS yöntemleriyle karşılaştırılmasında oldukça yüksek düzeyde ilişkiler tespit edilmiştir. CRADIS yönteminin mesafe tabanlı benzer sıralama yöntemlerinin yerine kullanılabileceği değerlendirilmektedir.
Yatırımcı duyarlılığının pay piyasası yatırımlarına etkisi: Borsa İstanbul’dan kanıtlar
Authors: YURTOĞLU Yasemin , SÜSAY Aynur
Published: July 2023

Bu çalışmanın amacı, 2007:01-2022:06 dönemi için yatırımcı duyarlılığının pay piyasası yatırımlarına etkisinin araştırılmasıdır. Çalışma, Borsa İstanbul Pay Piyasası’na yatırım yapan yabancı ve yerli yatırımcıların toplam portföy değerlerini kapsamaktadır. Yatırımcı duyarlılığı temsilinde çeşitli ölçütler kullanılmaktadır. Bu temsilcilerden biri olan ankete dayalı ölçütler bu çalışmanın değişkenlerini oluşturmaktadır. Dolayısıyla çalışmanın veri setini “yatırımcıların toplam portföy değerleri”, “Tüketici Güven Endeksi”, “Michigan Tüketici Güven Endeksi”, “Ekonomik Güven endeksi” ve “CBOE Volatilite Endeksi” oluşturmaktadır. Çalışmada Toda Yamamoto (1995) nedensellik testi uygulanmıştır. Çalışma sonucunda ilk olarak, ekonomik güven endeksi ile yatırımcılarının portföy değerleri arasında çift yönlü nedensellik ilişkisi tespit edilmiştir. İkinci olarak, Michigan tüketici güven endeksinden yatırımcıların portföy değerlerine doğru nedensellik ilişkisi olduğu bulgulanmıştır. Son olarak ise yatırımcıların portföy değeri ile tüketici güven endeksi arasında tek yönlü nedensellik ilişkisi olduğu saptanmıştır.
Guido of Arezzo. Micrologus Translation, commentary and introductory article by Sergey Lebedev
Authors: Лебедев С.Н.
Published: July 2023

«Микролог» Гвидо (1026–1030) — один из самых значимых и часто цитируемых трактатов в истории западной музыкальной науки. Эта публикация содержит полный перевод «Микролога» на русский язык, с подробными комментариями, нотными примерами и другого рода иллюстрациями. Многочисленные loci obscuri в тексте Гвидо, неоднозначность его терминологии обусловили необходимость дать параллельно переводу оригинал (так называемая билингва), в целом по крити- ческому изданию Й. М. Смитса ван Васберге. В приложении публикуется (также билингвой) анонимная интерполяция к 10-й главе «Микролога» (датируется XI веком), посвященная диесе, — это редкий для Средневековья пример описания практики использования микроинтервалов в григорианской монодии. Оба текста на русском языке публикуются впервые.

Guido’s Micrologus (written between 1026 and 1030) is one of the most important and frequently cited treatises in the history of Western music theory. This publication contains a complete Russian translation of the Micrologus, with detailed commentaries, sheet music examples, and other illustrations. The numerous loci obscuri in Guido’s text and the ambiguity of his terminology necessitated giving the original text (based on the critical edition of J. M. Smits van Waesberghe) in parallel with the translation. The Appendix contains (also in bilingual form) an anonymous interpolation to Chapter 10 of Micrologus on the diesis which dates back to the 11th century. This is a rare example of a description of the practice of microtonal intervals in medieval plainchant. Both texts are published in Russian for the first time.
T1 Anisotropy Elucidates Spin Relaxation Mechanisms in an S = 1 Cr(IV) Optically Addressable Molecular Qubit
Authors: Kazmierczak Nathanael , Luedecke Kaitlin , Gallmeier Elisabeth , Hadt Ryan
Published: July 2023

Paramagnetic molecules offer unique advantages for quantum information science owing to their spatial compactness, synthetic tunability, room-temperature quantum coherence, and potential for optical state initialization and readout. However, current optically addressable molecular qubits are hampered by rapid spin-lattice relaxation (T1) even at sub-liquid nitrogen temperatures. Here we use temperature- and orientation-dependent pulsed electron paramagnetic resonance (EPR) to elucidate the negative sign of the ground-state zero-field splitting (ZFS) and assign T1 anisotropy to specific degrees of freedom in an optically addressable S = 1 Cr(IV) molecular qubit. The anisotropy displays a distinct sin2(2θ) functional form that is not observed in S = ½ Cu(II) or V(IV) microwave addressable molecular qubits. The Cr(IV) T1 anisotropy is ascribed to couplings between electron spins and rotational motion in low-energy acoustic or pseudo-acoustic phonons. Our findings suggest that rotational degrees of freedom should be suppressed to maximize the coherence temperature of optically addressable qubits.
INSTANTANEOUS CONVERSION of AGRICULTURAL PLANT RESIDUES as ORGANIC FERTILIZER and it APPLICATION on MAIZE CULTIVATION: A COMPARATIVE STUDY with NPK AND MANURE.
Authors: Gideon Mathew , Kambai Duniya Emmanuel , Abakeyah James Mamman
Published: July 2023

Inorganic fertilizer can cause substantial environmental harm, fertilizer industries has never been involved in the valorisation of renewable resources. Residual biomass such as postharvest residues can be converted to fertilizer or substituted for some of the raw materials in fertilizer production. This study aims to develop eco-friendly and cost effective methods in which residual plant biomass can be instantaneously converted to organic fertilizer, and to compare it effect on the growth, development and yield on maize plants cultivation to NPK 20:10:5 and Rabbit manure, taking into account the organic fertilizer yield and conversion time as compared biochar and compost. Three different organic fertilizer (fertilizer A, B and C) were prepared using a combination of eleven (11) residual dry plant biomass and were formulated using calcium hydroxide, clay soil and thiourea for application on maize plant. Fertilizer C promote plant growth and development with better nutrient release compared to NPK 20:10:5, it was best when 11% by mass of thiourea was added with excellent yield above all sample used. Fertilizer C also showed higher residual organic matter compared to both NPK and manure, thus, showing that rapid and slow release of nutrient can be achieved without impacting the soil as the residual organic matter (carbon rich material) slowly decomposed. This study concluded that, the treatment given to agricultural plant residue determine its ability to be use in soil fertility and soil amendment, although there is need for more cost effective approach that will directly increase the nitrogen content in the organic fertilizer and to obtain a nutrient balance fertilizer.
Three-Coordinate Nickel and Metal-Metal Interactions in a Heterometallic Iron-Sulfur Cluster
Authors: Wilson Daniel , Fataftah Majed , Mathe Zachary , Mercado Brandon , DeBeer Serena , Holland Patrick
Published: July 2023

Biological multielectron reactions often utilize metalloenzymes with heterometallic sites, such as anaerobic carbon monoxide dehydrogenase (CODH) which has a nickel-iron-sulfide cubane with an unprecedented three-coordinate nickel site. Here, we isolate synthetic iron-sulfur clusters with three-coordinate nickel, which also have tungsten in one vertex. EPR, Mössbauer, and SQUID data are combined with DFT computations to show how the electronic structure arises from magnetic coupling between the Ni, Fe, and W sites. X-ray absorption spectroscopy favors a description as nickel(I) in two oxidation levels. Spectroscopically validated density-functional theory (DFT) calculations indicate that two electrons are stored in a nonpolar Ni-W bond. Because of the Ni-W bond, the nickel(I) site does not have substantial unpaired spin density. This gives insight into previous measurements on CODH, and generally suggests that metalloenzymes could store redox equivalents and stabilize low-valent metal centers through metal-metal bonding.
Tuning morphology, stability and optical properties of CsSnBr3 nanocrystals through bismuth doping for visible-light-driven applications
Authors: Adib Md Asif , Sharmin Fahmida , Basith Mohammed
Published: July 2023

In this investigation, we have demonstrated the synthesis of lead-free, CsSnBr3 (CSB) and 5 mol% bismuth (Bi) doped CSB (CSB′B) nanocrystals, with a stable cubic perovskite structure following a facile hot injection technique. The Bi substitution in CSB was found to play a vital role in reducing the size of the nanocrystals significantly, from 316±93 to 87±22 nm. Additionally, Bi doping has inhibited the oxidation of Sn2+ of CSB perovskite. A reduction in the optical band gap from 1.89 to 1.73 eV was observed for CSB′B and the PL intensity was quenched due to the introduction of BiSn3+ dopant. To demonstrate one of the visible-light-driven applications of the nanocrystals, photodegradation experiments were carried out as a test case. Interestingly, under UV-vis irradiation, the degradation efficiency of CSB′B is roughly one order lower than that of P25 titania nanoparticles, however, it is almost five times higher when driven by visible light under identical conditions. Moreover, by employing experimental parameters, DFT-based first-principles calculations were performed, which demonstrated an excellent qualitative agreement between experimental and theoretical outcomes. The as-synthesized Bi-doped CSB might be a stable halide perovskite with potential in visible-light-driven applications.
Is the functional response of a receptor determined by the thermodynamics of ligand binding?
Authors: Vögele Martin , Zhang Bin W. , Kaindl Jonas , Wang Lingle
Published: July 2023

Although strong binding to the target protein is a prerequisite, it is not enough to be an effective drug. To produce a particular functional response, drugs need to regulate the targets’ signal transduction pathways, either blocking the proteins’ functions or modulating their activities by changing the conformational equilibrium. The routinely calculated binding free energy of a compound to its target is a good predictor of affinity but may not always predict efficacy. While the time scales for the protein conformational changes are prohibitively long to be routinely modeled via physics-based simulations, thermodynamic principles suggest that binding free energies of the ligands with different receptor conformations may infer their efficacy if the functional response of the receptor is determined by thermodynamics. However, while this hypothesis was proposed in the past, it has not been thoroughly validated and is seldom used in practice for ligand efficacy prediction. We present an actionable protocol and a comprehensive validation study to show that binding thermodynamics provides indeed a strong predictor for the efficacy of a ligand. We apply the absolute-binding free energy perturbation (ABFEP) method to ligands bound to active and inactive states of eight G protein–coupled receptors (GPCRs) and a nuclear receptor. By comparing the resulting binding free energies, we can determine with a very high accuracy whether a ligand acts as an agonist or an antagonist. We find that carefully designed restraints are often necessary to efficiently model the corresponding conformational ensembles for each state and provide a procedure for setting up these restraints. Our method achieves excellent performance in classifying ligands as agonists or antagonists across the various investigated receptors, all of which are important drug targets.
Regularized weighted sine least-squares spectral analysis for gas electron diffraction data
Authors: Tikhonov Denis
Published: July 2023

Here, we present a new approach for obtaining radial distribution functions (RDF) from the electron diffraction data using a regularized weighted sine least-squares spectral analysis (rwsLSSA). It allows for explicitly transferring the measured experimental uncertainties in the reduced molecular scattering function to the produced RDF. We provide a numerical demonstration, discuss the uncertainties and correlations in the RDFs, and suggest a regularization parameter choice criterion.
Total Synthesis of Neohomohalichondrin B
Authors: Aitken Harry , Quach Rachelle , Kishi Yoshito
Published: July 2023

The total synthesis of neohomohalichondrin B has been achieved using a de novo sequence that enabled a highly convergent pathway to access the C38-C55 thioester fragment. The highlights of this synthesis include: (i) a tandem base-induced hydrolysis and rearrangement to access the C47-C50 tetrahydrofuran, and (ii) a Ni(I)/Ni(II)-mediated ketone coupling and acid-catalyzed cyclization sequence to access the C44 spiroketal and complete carbon framework of the left half fragment. The total synthesis of neohomohalichondrin B was completed following coupling of the left half thioester with a C1-C37 macrolactone iodide, according to our method for the unified synthesis of halichondrins. This synthetic strategy may facilitate an improved method to prepare other members of the halichondrin family, and analogues thereof.
THE PROBLEM OF ADVANCED TRAINING OF TEACHERS OF FACTORY APPRENTICESHIPS OF LUGANSK REGION (1920s)
Authors: Сафронов Г.П.
Published: July 2023

Статья посвящена анализу процесса организации повышения квалификации педагогов школ фабрично-заводского ученичества Луганщины в 1920-е гг. Необходимость скорейшего восстановления промышленных мощностей советского государства обусловила постановку перед системой народного образования стратегически важной задачи – организацию качественной подготовки рабочих промышленных предприятий. Вместе с тем особую актуальность приобрела проблема повышения квалификации педагогов школ фабрично-заводского ученичества. Для решения данной проблемы были открыты специальные учреждения дополнительного профессионального образования, в которых педагогическая и идеологическая подготовка сочетались с политическим просвещением педагогов, обучающих неквалифицированных рабочих промышленных предприятий.

The article is devoted to the analysis of the process of organizing advanced training of teachers of factory apprenticeship schools in Lugansk region in the 1920s. The need to restore the industrial capacities of the Soviet state as soon as possible led to the setting of a strategically important task for the public education system – the organization of highquality training of industrial workers. At the same time, the problem of professional development of teachers of factory apprenticeship schools has become particularly relevant. To solve this problem, special institutions of additional professional education were opened, in which pedagogical and ideological training were combined with the political education of teachers, training unskilled workers of industrial enterprises.
SỰ LAN TRUYỀN SÓNG ĐIỆN TỪ TRONG SIÊU VẬT LIỆU HYPERBOLIC VỚI ĐỘ THẤM ĐIỆN MÔI GẦN BẰNG KHÔNG
Authors: Nguyễn Phạm Quỳnh Anh , Lê Ngọc Minh
Published: July 2023

Trong bài báo này, chúng tôi nghiên cứu siêu vật liệu hyperbolic trên cơ sở cấu trúc chứa sợi kim loại kích thước nanomet nhúng trong nền điện môi bằng phương pháp lý thuyết môi trường hiệu dụng. Kết quả nghiên cứu cho thấy siêu vật liệu hyperbolic với độ thấm điện môi gần bằng 0 (ENZ) có thể tồn tại cùng lúc ở loại I và loại II. Điểm đặc biệt lan truyền sóng điện từ phân cực từ ngang được nghiên cứu trong hai loại siêu vật liệu này. Chùm ánh sáng đến phân kỳ dường như chuyển thành chùm sáng chuẩn trực tốt và chuyển toàn bộ năng lượng theo hướng vuông góc với bề mặt siêu vật liệu hyperbolic loại I trong vùng giá trị đặc biệt của góc tới từ –5 đến 5°. Trong siêu vật liệu hyperbolic loại II, sóng ánh sáng truyền hoàn toàn qua lớp cấu trúc vật liệu; đồng thời, giá trị hệ số truyền qua không đổi trong vùng giá trị góc tới từ –40 đến 40°. Sự thay đổi bán kính sợi kim loại trong cấu trúc và độ dày của lớp siêu vật liệu có ảnh hưởng đến đặc tính lan truyền sóng điện từ.
SỰ KẾT HỢP GIỮA NGHIÊN CỨU THỰC NGHIỆM VÀ TÍNH TOÁN HOÁ LÝ THUYẾT TRONG VIỆC KHẢO SÁT TIỀM NĂNG CHỐNG OXI HOÁ CỦA GALLIC ACID
Authors: Đinh Quý Hương
Published: July 2023

Khả năng chống oxy hoá của 3,4,5-trihydroxybenzoic acid (gallic acid) đã được nghiên cứu bằng các phương pháp phổ, gồm 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS•+), phosphomolybdenum và các tính toán hoá lượng tử ở mức lý thuyết w-B97XD/6-311++G(d,p). Kết quả cho thấy gallic acid có khả năng bắt gốc tự do DPPH• và ABTS•+ mạnh hơn trolox với các giá trị IC50DPPH và IC50ABTS là 2,23 ± 0,02 và 12,20 ± 0,03 μM. Trong phương pháp phosphomolybdenum, gallic acid có khả năng khử Mo(VI) về Mo(V) tương đương với trolox. Cơ chế phản ứng giữa gallic acid và HOO• theo tính toán hoá lượng tử chủ yếu là chuyển nguyên tử hydro.
Long-Term Dynamics of Fires in the Southern Steppes of the Northern Caspian and Mugodzhar
Authors:   Institute of Steppe UB RAS, Pavleichik V. M. , Sivohip Zh. T. ,   Institute of Steppe UB RAS
Published: July 2023

The purpose of the study is to identify regional features of the formation and long-term dynamics of grass fires in the southern steppes. A vast expanse covering mainly the southern steppe landscapes of the small-scale Mugodzhara massif, the plains of the Northern Caspian and Turgai is accepted as the key territory. The presented results are based on the analysis of the formed database of geospatial data containing information about the time and spread of fires for 1986-2021. The source materials were satellite images of Landsat and MODIS (Terra and Aqua satellites). As an indirect indicator of the pyrological state of the steppes, long–term statistical data on the number of grazed cattle (cattle, sheep and goats, horses). A significant heterogeneity of the pyrologic conditions for the years under review was revealed, three phases were identified: low (1986–2000), high (2001– 2010) and medium (2011–2021) fire activity. A comparison of the data obtained with the results of similar studies conducted by the authors earlier on the northern steppes indicates a high degree of similarity in the long-term dynamics of wildfires. By identifying the closeness of connections, it was established that the observed changes in the nature of fire–hazardous situations are due to changes in the intensity of use of plant and land resources, mainly during the agricultural development of the region. The intensification of fires was the result of the spontaneous restoration of steppe vegetation on uncultivated arable and little-used pasture lands associated with a sharp reduction in the level of agricultural production in the countries of the former USSR. It took about 8 years to restore the previously degraded vegetation to a state capable of supporting the steady spread of fires. One of the factors of pyrogenicity is the floral composition of plant communities and the density of herbage. The deterioration of the pyrological situation in the southern steppes (as well as in other steppe subzones) has become a specific regional response to the changed conditions.
АКУСТИЧЕСКИЕ ВОЛНЫ В РАЗРЕЖЕННОЙ ВЫСОКОТЕМПЕРАТУРНОЙ ПЛАЗМЕ
Authors: Бембитов Д. Б. , Дертеев С. Б. , Шивидов Н. К. , Михаляев Б. Б.
Published: July 2023

Изучается поведение акустических волн в разреженной высокотемпературной плазме, в качестве примера которой рассматривается плазма солнечной короны. Учитываются эффекты теплопроводности и нагрева/радиационных потерь, используются данные о температурном распределении интенсивности излучения. Для функции излучения построено аналитическое представление в виде интерполяции кубическими сплайнами. В приближении газовой динамики получено дисперсионное соотношение для акустических волн, из которого найдены частота, фазовая скорость и коэффициент затухания. Показано в целом превосходство в дисперсии и затухании эффекта теплопроводности, нагрев и радиационные потери проявляют себя при больших длинах волны.
ИМПУЛЬСЫ НЕЙТРОННОГО И ЖЕСТКОГО РЕНТГЕНОВСКОГО ИЗЛУЧЕНИЯ КАМЕРЫ ПЛАЗМЕННОГО ФОКУСА ПРИ РАЗРЯДНЫХ ТОКАХ 100-200 КА
Authors: Юрков Дмитрий Игоревич , Лавренин Виктор Анатольевич , Лемешко Борис Дмитриевич , Михайлов Юрий Владимирович , Прокуратов Илья Александрович
Published: July 2023

В работе рассмотрена генерация нейтронного и жесткого рентгеновского излучений (ЖРИ) камерами плазменного фокуса при работе в составе субкилоджоульного нейтронного генератора ИНГ-102Э с емкостью накопителя 4.4 мкФ и амплитудой разрядного тока через электроды камеры в диапазоне от 100 до 200 кА. Использована камера типа Т19-Л316, обеспечивающая выход нейтронов с энергией 2.5 МэВ на уровне 105–107 нейтр./имп. Проведено изменерение уровня выхода нейтронов и ЖРИ камеры Т19-Л316, показано наличие режимов работы с генерацией ЖРИ без нейтронного излучения при дейтериевом наполнении камеры. Определена длительность импульсов нейтронов камеры Т19-Л316 и изучена зависимость длительности от уровня выхода нейтронов и от состава рабочего газа в камере ПФ. Экспериментально подтверждена работа камеры ПФ в безнейтронном режиме при заполнении объема камеры водородом и проведено сравнение уровня выхода ЖРИ при работе с водородом, дейтерием и дейтерием с примесью аргона. Также предложен вариант конструкции камеры Т19-Л316 для генерации нейтронов с пониженным до 100 раз выходом ЖРИ, реализуемый за счет изменения конструкции камеры.
Reporting as a source for assessing the achievements of the CSR in the conditions of digitalization: improving the organization of the presentation
Authors: Kucheriava Maria , Nebis Vitalii , Ismail Tariq H.
Published: July 2023

The current trend towards building a system of sustainable socio-economic, environmental, institutional development of society affects all areas of enterprise reporting. The article is devoted to solving the problem of increasing the transparency and quality of information in the report on payments to the state, as well as simplifying the process of its formation and presentation. The following research methods are used in the work: bibliographic analysis, comparative analysis, synthesis, generalization. An assessment was made of the possibility of cross-referencing financial statements prepared under the XBRL IFRS Taxonomy when preparing a report on payments to the state by enterprises engaged in the extractive industries and enterprises engaged in logging. With the help of a comparative analysis, it was proved that in order to report on payments to the state by enterprises in a single electronic format, it is necessary to develop additional industry-specific extensions to IFRS XBRL.
Optimizing Lectin Staining Methodology to Assess Glycocalyx Composition of Legionella-Infected Cells
Authors: Kothari Sajani , Heineman Rebecca , Harrison Rene
Published: July 2023

Introduction: Legionella is a gram-negative bacterium that replicates intracellularly within macrophages. Legionella utilizes effector proteins to hijack ER-Golgi vesicle trafficking to sustain proliferation in its intracellular niche. Legionella has a considerable influence on O-glycosylation but not N-glycosylation events in the Golgi of infected cells. This research aims to optimize the use of fluorescent lectins, which are proteins that bind carbohydrates, to effectively label host-cell glycocalyx during Legionella infection. Methods: Epifluorescence imaging or flow cytometry were used to optimize the lectin staining methodology. We noted that the most effective conditions for lectin-labeling were when live HeLa cells were incubated with lectins diluted in Hank’s balanced salt solution (HBSS) with 3% Bovine serum albumin (BSA) for 10-30 minutes at 4 °C. Results: Incubating suspended cells with lectins necessitated smaller lectin concentrations, whereas lectin labeling of adherent cells required considerably larger concentrations. Wheat germ agglutinin (WGA) lectin mean fluorescence intensity (MFI) was concentration-dependent, but Concanavalin A (ConA) and Maclura pomifera (MPA) MFIs did not alter substantially with increasing lectin concentrations. Discussion: The optimal lectin concentration required was lectin-specific and based on whether the lectin fluorescence was assessed using flow cytometry or epifluorescence. Furthermore, the use of phosphate-buffered saline (PBS) for lectin dilution, cell permeabilization for intracellular labelling, and incubation of lectins in fixed cells reduced productive labelling of lectins on cell surfaces because it inhibited the lectin's ability to effectively bind the associated carbohydrate structure. Conclusion: Further research using diverse lectins on U937 macrophages is necessary to reach a definitive conclusion on the effect of Legionella on the overall host-cell glycocalyx composition during infection of these relevant immune cells.
Reflexiones desde la disciplina de la enfermería sobre ajustes razonables en salud para la atención de personas con discapacidad psicosocial en Colombia
Authors: Gonzalez Hurtado Lauren Melissa , Ramírez Gordillo Erika Alexandra , Buitrago Gutiérrez Ivonne
Published: July 2023

Se asume que todos los humanos deben tener acceso a una atención en salud de calidad; no obstante, las personas con discapacidad psicosocial en Colombia encuentran obstáculos debido a múltiples causas, entre ellas, el desconocimiento de los ajustes razonables. El interés de este artículo es reflexionar sobre la atención en salud desde los ajustes razonables para las personas con disfunciones temporales o permanentes, que afectan su forma de pensar, sentir o comportarse, limitando sus actividades cotidianas. La disciplina de la enfermería aporta en términos de reflexión y gestión junto al equipo de salud, acerca de los ajustes razonables en los servicios de salud, los estereotipos sociales y las consecuencias para los sujetos de cuidado.
Matriz Discursiva. Propuesta de una categoría analítica de alcance medio para una historia conceptual de lo político
Authors: Tobares Javier 
Published: July 2023

Resumen

En este artículo estudiamos, en el marco híbrido de una historia conceptual de lo político y del análisis del discurso, una categoría analítica de alcance medio llamada “matriz discursiva”, entendida como perspectiva capaz de examinar la contingencia de los procesos históricos. Para tal propósito hemos elegido el concepto de pueblo, lo que nos permite mostrar de modo operativo cuáles son los supuestos que confluyen en la mencionada idea de matriz discursiva.

Palabras clave

Historia conceptual, análisis del discurso, matriz discursiva, pueblo, escritura académica
La influencia de la historiografía católica en el estudio del pasado medieval peninsular (siglos XIX-XXI)
Authors: García Sanjuan Alejandro
Published: July 2023

ResumenEn el marco de la construcción del Estado liberal, la historiografía decimonónica española, fuertemente influida por la tradición católica, elaboró un relato histórico que tuvo entre sus objetivos esenciales establecer la existencia de una unión inextricable entre la nación española y el catolicismo. Evidentemente, uno de los grandes retos a los que se enfrentaban quienes promovían la identidad exclusivamente católica de la nación española era la dilatada presencia musulmana en Iberia durante ocho siglos. El franquismo supone la quiebra de la tradición historiográfica liberal y, al mismo tiempo, el apogeo del nacionalcatolicismo, si bien, paradójicamente, el principal representante de la historiografía medieval fue un republicano antifranquista, aunque profundamente católico, como Claudio Sánchez-Albornoz. A partir del período democrático, la historiografía católica pierde parte de su influencia, pero mantiene una amplia presencia en el estudio del período medieval, tanto gracias a la actividad de autores e instituciones confesionales como a la asunción por parte de otros sectores académicos de los postulados que emanan de dichos sectores.

Palabras clave

Españolismo, historiografía católica, nacionalcatolicismo, Reconquista, identidad cristiana, ultraderecha.
Escucha dicótica: hipoacusia, desordenes del pensamiento auditivo central en adolescentes
Authors: Patiño Zambrano Viviana Paola , Cedeño Mero Robin Edison , Morales Coloma Martha Johanna , Patiño Zambrano Walter Alejandro
Published: July 2023

La audición es un proceso complejo, mucho más de lo que se considera habitualmente. Es así como desde la llegada del sonido al tímpano hasta la percepción de éste, un número importante de operaciones mecánicas y neurobiológicas tienen lugar dentro del sistema auditivo. La presente investigación se enmarca dentro de una metodología de tipo bibliográfica documental. Ya que es un proceso sistematizado de recolección, selección, evaluación y análisis de la información, que se ha obtenido mediante medios electrónicos en diferentes repositorios y buscadores tales como Google Académico, Science Direct, Pubmed, entre otros, empelando para ellos los diferentes operadores booleanos y que servirán de fuente documental, para el tema antes planteado. Los trastornos del pensamiento auditivo central pueden ocasionar hipoacusia, uno de los diagnósticos que se pueden emplear para confirmar esta condición es la escucha dicótica, por medio del test de números dicóticos. No existen dentro de la bibliografía consultada muchos trabajos que aborden esta patología en la adolescencia, en muchos casos la bibliografía revisada, realiza estudios con niños en rangos de edades que pueden sesgar los resultados en cuanto criterios para la toma de edad de la adolescencia, aparte que, generalmente suele ser diagnosticada en la niñez, con su asociación al rendimiento académico.
Sistemas alternativos de comunicación: estrategias de tratamiento en el desarrollo del lenguaje en niños con TEA
Authors: Sáenz Rangel María Dolores , Alvarado Espinoza Sofía Magaly , Morales Peralta Ángela Matilde , Guerrero Pozo Erika Pilar
Published: July 2023

Los trastornos del espectro autista (TEA) son trastornos del neurodesarrollo caracterizados por deficiencias persistentes en la comunicación social y patrones de comportamiento repetitivo y restrictivo. Las personas con TEA presentan perfiles de funcionamiento muy variados que dan lugar a fenotipos diversos, cambiando en función de la edad, la capacidad intelectual, patologías asociadas, ayudas recibidas. La presente investigación se enmarca dentro de una metodología de tipo bibliográfica documental. Ya que es un proceso sistematizado de recolección, selección, evaluación y análisis de la información, que se ha obtenido mediante medios electrónicos en diferentes repositorios y buscadores tales como Google Académico, Science Direct, Pubmed, entre otros, empelando para ellos los diferentes operadores booleanos y que servirán de fuente documental, para el tema antes planteado. Los niños diagnosticados dentro del Trastorno del Espectro Autista, a pesar de las limitaciones que puedan tener en base a su grado de autismo, también tienen derecho a aprender, ya que en algunos casos estos niños lo que tienen son pequeñas diferencia y dificultados, con respecto a los niños que no han sido diagnosticados con TEA. Lo importante aquí es el diagnostico oportuno y temprano, lo que permitirá tanto al niño como a los padres, con un acompañamiento especializado, darle las herramientas necesarias para su desarrollo integral, en lo que tiene que tiene que ver en lo educacional, emocional, comunicativo, entre otros.
Sistema de compensación laboral y la mitigación del absentismo laboral en la empresa Eurofish
Authors: Moreira Carreño Viviana Elizabeth , Romero Vélez Eva Marisol
Published: July 2023

Un sistema de compensación laboral balanceado genera efectos positivos en el desempeño laboral e institucional sino produce un deterioro en la calidad del entorno laboral. En los peores casos, el deseo de obtener mejor compensación disminuye el desempeño, eleva las quejas y aumenta la fluctuación laboral. Además, el escaso interés que despierte una función compensada pobremente lleva al ausentismo y otras formas de protesta pasiva. De manera tal que en la investigación se planteó como objetivo diseñar un sistema de compensación laboral que contribuya a la mitigación del absentismo laboral en los colaboradores de la empresa Eurofish. La metodología utilizada tuvo como alcance una investigación de tipo descriptiva y explicativa, con el uso de entrevistas, encuestas y grupo focal. El resultado fue un sistema de compensación laboral basado en una serie de estrategias para minimizar el ausentismo en la empresa Eurofish.
PKM Senam Lansia Kelompok Wanita Tani Puspitasari Sampangan
Authors: Prastiwi Bertika Kusuma , Ratimiasih Yulia , Wibisana Muh Isna Nurdin , Pratama Dani Slamet , Setiyawan Setiyawan , Widyatmoko Fajar Ari , Wardhana Buyung Kusuma
Published: July 2023

ABSTRACTGymnastics is a sport that is known by the public. The form of socialization is very important to popularize and introduce gymnastics. The Puspitasari women's group in RW 03 Sampangan city of Semarang is one of the many RW that hold gymnastics but only aerobics is done, because of that the elderly are less enthusiastic about participating in activities even though they want gymnastics that are suitable for the elderly. The solution offered is to provide elderly exercise training for the Puspitasari elderly women group in RW 03 Sampangan. The resulting output is that the elderly can exercise according to their age characteristics with elderly exercise. The PKM activities carried out by the UPGRIS community service team for the women's group Puspitasari RW 03 Sampangan Semarang used lecture methods, demonstrations and independent practice, besides that gymnastic simulations were also held. The result of this service is an increase in the knowledge and skills of the elderly women's group about elderly gymnastics, besides that it has an impact on the interest in elderly gymnastics for the women's group puspitasari RW 03 Sampangan Semarang. Gymnastics according to the age characteristics of the elderlyABSTRAKSenam merupakan olahraga yang dikenal oleh masyarakat. Bentuk sosialisasi sangat penting untuk memasyarakatkan dan mengenalkan olahraga senam. Kelompok wanita Puspitasari di RW 03 Sampangan kota Semarang merupakan salah satu dari sekian banyak RW yang mengadakan senam tetapi hanya senam aerobik yang dilakukan, karena itu para lansia kurang    antusias untuk mengikuti kegiatan padahal mereka menginginkan senam yang cocok bagi lansia. Solusi yang ditawarkan adalah memberikan pelatihan senam lansia untuk kelompok wanita  lansia Puspitasari di RW 03 Sampangan. Luaran yang dihasilkan adalah para lansia dapat berolahraga sesuai dengan karakteristik umur dengan senam lansia. Kegiatan PKM yang dilakukan tim pengabdian UPGRIS pada kelompok wanita Puspitasari  RW 03 Sampangan Semarang ini menggunakan metode ceramah, demonstrasi dan praktek mandiri, disamping  itu juga diadakan simulasi senam. Hasil dari pengabdian ini adalah bertambahnya pengetahuan dan keterampilan kelompok wanita lansia tentang olahraga senam lansia, di samping itu berdampak pada minat olahraga senam lansia kelompok wanita puspitasari RW 03 Sampangan Semarang. Senam sesuai dengan karakteristik umur lansia.
Analisis Nilai Moral dalam Novel Anak Sejuta Bintang Karya Akmal Nasery Basral sebagai Alternatif Bahan Ajar SMA
Authors: Pertiwi Elok Setyo , Septiana Ika
Published: July 2023

This Study aims to Find and describe the moral values contained in the children’s novel a millon stars by akmal nasery basral. This research use  desciptive qualitatif approach. The results of this study  found in the ‘asb’ novel are the moral value of wisdom (bj), the moral value of compassion (ks), the moral value of not giving up (tpa), the moral value of discipline (d), the moral value of being generous (de), the moral value of being helpful (sm), pateint moral value (s), diligent moral value (j), hard work moral value (kk), responsibility moral value (c), courageous moral value (b), firm moral values (tgs), tough moral values (tgr), tenacious moral values (u), fair moral values (a), and orderly (t).Keywords: analysis of moral values, alternative teaching materials, in novels AbstrakPenelitian ini bertujuan untuk menemukan dan mendeskripsikan nilai-nilai moral yang terkandung di dalam Novel ‘Anak Sejuta Bintang’ karya Akmal Nasery Basral. Penelitian ini menggunakan pendekatan Deskriptif Kualitatif. Hasil dari penelitian ini ditemukan dalam novel ‘asb’ adalah nilai moral bijaksana (bj), nilai moral kasih sayang (ks), nilai moral tidak putus asa (tpa), nilai moral disiplin (d), nilai moral dermawan (de), nilai moral suka menolong (sm), nilai moral sabar (s), nilai moral tekun (tk), nilai moral jujur (j), nilai moral kerja keras (kk), nilai moral tanggung jawab (tj), nilai moral cerdas (c), nilai moral berani (b), nilai moral tegas (tgs), nilai moral tegar (tgr), nilai moral ulet (u), nilai moral adil (a), dan tertib (t).Kata kunci: analisis nilai moral, alternatif bahan ajar, dalam novel
Analisis Kohesi Gramatikal dan Leksikal pada Wacana Narasi Buku Teks Bahasa Indonesia Kelas XII
Authors: Safitri Riska Nurul , Indrariani Eva Ardiana , Prayogi Icuk
Published: July 2023

The paper repots on the reasult of a study was to describe the form of grammatical and lexical cohesion classification in the narrative discourse of class XII Indonesian textbooks. The method of providing data used in this research is the documentation method with the note-taking technique. The data analysis method used the agih method with the basic technique for direct elements (BUL) and advanced techniques in the form of replace, lesap, and insert techniques. Based on the research conducted, it was found that the use of grammatical and lexical cohesion in the narrative discourse of Indonesian language textbooks for class XII was found in the form of grammatical cohesion in the form of references, substitutions, and conjunctions. The use of lexical cohesion in the form of repetition, synonymy, antonym, collocation, and equivalence. ABSTRAK Tujuan penelitian ini adalah untuk mendeskripsikan bentuk klasifikasi kohesi gramatikal dan leksikal pada wacana narasi buku teks bahasa Indonesia kelas XII. Metode penyediaan data yang digunakan dalam penelitian ini adalah metode dokumentasi dengan teknik catat. Metode analisis data menggunakan metode agih dengan teknik dasar bagi unsur langsung (BUL) dan teknik lanjutan berupa teknik ganti, lesap, dan sisip. Berdasarkan penelitian yang dilakukan, ditemukan bentuk penggunaan kohesi gramatikal dan leksikal pada wacana narasi buku teks Bahasa Indonesia kelas XII dalam bentuk kohesi gramatikal berupa referensi, subtitusi, dan konjungsi. Penggunaan kohesi leksikal berupa repetisi, sinonimi, antonimi, kolokasi, dan ekuivalensi.
The Security Assignment Problem and Its Solution
Authors: Longhas Paul Ryan A. , Abdul Alsafat M. , Baccay Edcon B.
Published: July 2023

In this paper we derived a new method for finding the optimal solution to security assignment problems using projection onto a convex set. This study will help communities find the optimal number of assigned and reserved personnels in designating security officers to an area. This study is applicable as well to CCTV assignment problems. The main goal of this study is to give a new method that can be applied in solving security assignment problems. We used some of the known properties of the convex optimization in proving the properties of the optimal solution, such as the concept of proximity operator, projection onto the convex set, and primal and dual problem. In addition to that, we used some basic knowledge in graph theory to answer our real-life application of this study. The main results of this paper showed that we found instances when the optimal solution to a security problem exists and when the solutions exist, we can determine the answer to the problem explicitly. Also, we proved that there always exists a Pseudo-solution in security assignment problems, and if the solution exists, then the Pseudo-solution will coincide with it. The most important aspect of this paper is the introduction of the application of convex optimization in the security problem.