bluuebunny/crossref_metadata_2025 huggingface dataset:
The Proper Interplay Between the Expression of Spo11 Splice Isoforms and the Structure of the Pseudoautosomal Region Promotes Xy Chromosomes Recombination
Authors: Giannattasio Teresa , Testa Erika , Faieta Monica , Lampitto Matteo , Nardozi Daniela , Cecca Stefano Di , Russo Antonella , Barchi Marco
Published: August 2023

XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid spermatozoa. A leading cause of XY missegregation in mammals is the lack of formation of double-strand breaks (DSBs) in the pseudo-autosomal region (PAR), a defect that may occur in mice due to faulty expression of Spo11 splice isoforms. Using a knock-in (ki) mouse that expresses only the single Spo11β splice isoform, here we demonstrate that by varying the genetic background of mice, the length of chromatin loops extending from the PAR axis and the XY recombination proficiency varies. In spermatocytes of C57Spo11βki/- mice, in which loops are relatively short, recombination/synapsis between XY is fairly normal. In contrast, in cells of C57/129Spo11βki/- males where PAR loops are relatively long, formation of DSBs in the PAR (more frequently the Y-PAR) and XY synapsis fails at a high rate, and mice produce sperm with sex-chromosomal aneuploidy. However, if the entire set of Spo11 splicing isoforms is expressed by a wild type allele in the C57/129 background, XY recombination and synapsis is recovered. By generating a Spo11αki mouse model, we prove that concomitant expression of SPO11β and SPO11α isoforms, boosts DSB formation in the PAR. Based on these findings, we propose that SPO11 splice isoforms cooperate functionally in promoting recombination in the PAR, constraining XY asynapsis defects that may arise due to differences in the conformation of the PAR between mouse strains."
Anti-inflammatory effects of n-3 polyunsaturated fatty acids in THP-1 macrophages: promising in-vitro insights
Authors: Hinai Hamed Al , Hooper Sam , Potter Steve , Alawi Sulaiman Amur Al , Shuhoumi Mohammed Al , Anna Dorel
Published: August 2023

Objectives
Uncontrolled inflammation is a one route to the pathogenesis and development of inflammatory diseases. The scientific literature has reported many evidences supporting the notion that polyunsaturated fatty acids (PUFAs) belonging to the family of n-3 including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have an anti-inflammatory function. Although much has been learned about EPA and DHA, so many questions remain unanswered, including the differential effects on health of DHA and EPA as well as the dose-response effect on clinical outcomes. The present study is aimed to investigate the effect of the PUFAs; EPA and DHA in the inflammatory responses in LPS-stimulated THP-1 macrophages.
Methods
Cells were incubated for 24 and 48 hours with EPA and DHA. Cell viability test were used to determine the viability of cells during and after incubation. Doses concentrations of 0.09 and 0.45 mM for both EPA and DHA were utilized to study the expression levels of inflammatory cytokines that were measured by ELISA test. All data were presented as SEM and subjected to normality test by Anderson and Pearson tests and the statistical significance difference was determined via one-way ANOVA test.
Results
Our study revealed interesting findings that are in a significant agreement to other studies in the literature. DHA illustrated a decrease on the levels of IL-6 in LPS-stimulated THP-1 cells treated with 0.09 mM, and a greater reduction with 0.45 mM DHA concentration (P < 0.001). Moreover, DHA in our study, achieved no statistically significant difference in TNF-alpha inflammatory cytokines compared to cells alone (P < 0.001). On the other hand, LPS-stimulated THP-1 cells, when subjected to EPA, it showed a significant decline in both IL-6 and TNF-alpha in the higher dose only and failed to express a statistically significant difference in 0.09 mM (P < 0.001).
Conclusion
In conclusion, our data support the notion that PUFAs represented in EPA and DHA, are capable to reduce the expression of inflammatory cytokines. DHA stands out as a more potent anti-inflammatory agent which is a suggestive for a valuable marker to fight chronic diseases. Both in-vivo animals and human trials are urgently demanded to validate our current data.
Der Entzug des Bürgerrechts. Eine Einordnung der Schweizer Praxis
Authors: Von Rütte Barbara
Published: August 2023

Bundesgericht und Bundesverwaltungsgericht haben sich im vergangenen Jahr zum ersten Mal mit der Frage auseinandersetzen müssen, unter welchen Voraussetzungen der Entzug des Schweizer Bürgerrechts gemäss Art. 42 des Bürgerrechtsgesetzes rechtmässig ist. Dabei äussern sich die Gerichte auch zu den neu in Art. 30 der Bürgerrechtsverordnung geregelten Voraussetzungen für einen Entzug des Bürgerrechts. Die beiden Urteile bieten Anlass für eine kritische Diskussion der aktuellen Ausbürgerungspraxis der Schweiz, insbesondere mit Blick auf das Diskriminierungsverbot und das Verhältnismässigkeitsprinzip.

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L'année dernière, le Tribunal fédéral et le Tribunal administratif fédéral ont examiné pour la première fois les conditions permettant un retrait de la nationalité selon l'art. 42 de la loi sur la nationalité suisse. A cette occasion, les tribunaux se sont également prononcés sur les conditions nouvellement réglées à l'art. 30 de l'ordonnance sur la nationalité suisse. Ces deux arrêts donnent lieu à une discussion critique à propos de la pratique actuelle en matière de déchéance de la nationalité suisse, notamment au regard des principes de l'interdiction de la discrimination et de proportionnalité.
Sistemas de aquisição de equipamentos de defesa no Brasil e na suécia
Authors: Ambinder Carolina , Brustolin Vitelio
Published: August 2023

Neste artigo, são mapeados os principais atores dos sistemas de aquisição de equipamentos de defesa no Brasil e na Suécia, utilizando-se uma metodologia de análise comparativa, por meio de revisão da literatura, entrevistas e análise documental. Para tanto, são discutidos, inicialmente, conceitos basilares ao tema, como poder, capacidade e governança, bem como, os aspectos teóricos do próprio sistema de aquisição, do modelo hélice-tripla e da área de políticas públicas. Na sequência, é contextualizada a formação das indústrias de defesa do Brasil e da Suécia, a fim de se produzir considerações sobre o estágio atual dos referidos sistemas. Nas conclusões, constata-se que, apesar de iniciativas para uma maior integração no setor de defesa brasileiro, como a criação do Ministério da Defesa (MD) e da Secretaria de Produtos de Defesa (SEPROD), o sistema de aquisição do país ainda é descentralizado. Na Suécia, por sua vez, o sistema de aquisição de defesa aplica-se às três Forças, conjuntamente, contando com outros atores determinantes no processo.
Responsible and profitable: How does ESG agenda increases company’s evaluation
Authors:   HSE University, Nazarova Varvara V. , Churakova Iya Yu. ,   HSE University, Sergachev Boris D. ,   HSE University, Orekhovskaya Milena A. ,   HSE University
Published: August 2023

This study evaluates the differences in environmental, social, and governance factors (ESG) affecting firm value by examining the rating for aggregate ESG and for each factor separately in developed and developing countries. Innovative industry companies as well as heavy industry companies are taken as examples. The paper demonstrates that the effect of ESG rating on the Tobin coefficient, taken as a proxy variable for firm value, differs across industries in developed and developing countries. Based on the observations of 4 207 firms from 35 countries over the period of 2016–2021, the findings demonstrate that the ESG ratings have a positive effect on firm value in developed countries and in innovative industries; the above-mentioned effects are persistent. It also shows that G score is important for the same groups of companies, however, for the firms registered in developing countries, an E score is sufficient in the short term. The paper concludes that lagged variables have a bigger impact on the results in heavy industries that demonstrate their concentration on internal operations, not on investors’ attention directed at the ESG factors. The findings are significant for scholars, managers and policymakers.
AGENDA 2030 E O CONTEXTO DO DESENVOLVIMENTO HUMANO E DAS TECNOLOGIAS ASSISTIVAS PARA O ACESSO AO TRABALHO DECENTE DE PESSOAS COM DEFICIÊNCIA
Authors: Prado Vaner Jose do , Santos Luciana Rodrigues dos
Published: August 2023

Este estudo visa refletir sobre dados que apontam a existência de mais de 45 milhões de brasileiros que possuem algum tipo de deficiência. Nesse contexto, considerando o prazo de 15 anos estabelecido pela Agenda 2030, para que os Estados membros da Organização das Nações Unidas (ONU) consigam cumprir os objetivos e metas dispostos no referido documento, questiona-se: de que maneira a tecnologia assistiva (TA) pode interferir para o trabalho decente (8º Objetivo Desenvolvimento Sustentável) e desenvolvimento humano da pessoa com deficiência (PCD)? O objetivo é compreender a importância das políticas públicas direcionadas à tecnologia assistiva (TA) como meio de possibilitar o trabalho decente, o desenvolvimento humano e sustentável e a inclusão social das pessoas com deficiência. A pesquisa possui natureza descritiva, no sentido de compreender a partir da exploração de dados secundários alguns dos caminhos trilhados para encontrar algumas das respostas esperadas. Como resultados centrais denota-se que apesar da regulamentação da acessibilidade por meio da TA no âmbito laboral, a PCD continua a ser vista segundo o modo depreciativo da diversidade tida como um entrave ao processo organizacional e não a diversidade de forma ampla, considerando que o ser humano carrega consigo múltiplos e diferentes conhecimentos e culturas, que podem agregar na consecução de suas atividades laborais e na relação interpessoal no trabalho, revelando a imprescinbilidade da atuação política para efetivar uma inclusão substancial.
(DES)ENCONTROS ENTRE HOMESCHOOLING E ABORTAMENTO VOLUNTÁRIO
Authors: SALIBA MOREIRA PINTO SAMUEL , NEVES PINTO GERSON
Published: August 2023

Pretende-se uma análise comparativa entre as argumentações relacionadas com o homeschooling e o abortamento voluntário, a fim de se verificar se há contradição entre a defesa de um e a contrariedade ao outro. Ambos envolvem questões familiares e tangenciam uma dimensão pública, i. e., há um interesse público quanto à proteção integral da pessoa em desenvolvimento, quanto ao produto da gravidez e sua expectativa de tornar-se uma pessoa, bem como quanto à gestante e seu corpo. Se no primeiro caso a tensão é entre tutores e tutelados, no segundo caso é entre a pessoa gestante e o produto da gravidez. Em um há a tutela da educação e todos os seus desdobramentos e no outro há a liberdade da pessoa gestante, já que no atual estado da arte da reprodução, a humana é vivípara. Identificou-se que os discursos sobre homeschooling e abortamento voluntário têm o mesmo ponto de partida (o que pode gerar uma aparente incompatibilidade), mas dirigem-se a valores diferentes; logo, não se verifica contradição entre a defesa de um e a contrariedade de outro, ou a contrariedade ou defesa de ambos.
MULTIPROPRIEDADE
Authors: Amin Ferraz Daniel , Fonte Guimarães Antonio Marcos
Published: August 2023

O mercado imobiliário ocupa papel de destaque na circulação de riqueza em qualquer nação. Em decorrência disso, toda inovação que traga avanços nesse setor, seja promovendo desburocratização de processos ou redução de custos, é meritória. Nesse diapasão, a tokenização de ativos imobiliários traz boas perspectivas na viabilização de um negócio contínuo e sustentável nesse mercado. Ocorre que, a forma como esse processo inovador vem sendo operacionalizado no Brasil, ainda que de forma incipiente, traz uma série de fragilidades jurídicas que podem comprometer o sucesso desse mecanismo tão promissor. Argumenta-se, neste trabalho, que, a despeito dos louváveis aprimoramentos promovidos pela intervenção da Corregedoria do Tribunal do Estado do Rio Grande do Sul, dispondo sobre a forma de averbação do processo em cartórios de registros de imóveis, há um instrumento jurídico mais eficaz presente na legislação brasileira, que agregará maior segurança jurídica às partes envolvidas nessa contratação. Trata-se, a propósito, do instituto da multipropriedade, regulado pela Lei nº 13.777, de 20 de dezembro de 2018, o qual promoveu alterações no Código Civil e na Lei de Registros Públicos, Lei nº 6.015, de 31 de dezembro de 1973, com vistas a disciplinar a prática do Time Sharing no Brasil. Mecanismo inspirado no direito norte-americano.
DIAGNÓSTICO DE PARÂMETROS ORIENTADORES À ATUAÇÃO DO BANCO CENTRAL DO BRASIL COMO REGULADOR E GESTOR DO PIX
Authors: Carneiro Neves Rúbia , Alves Freire Lucas
Published: August 2023

Neste trabalho, demonstrou-se que o ordenamento jurídico brasileiro oferece balizas capazes de orientar a atuação equilibrada do Banco Central do Brasil (BCB) para regular e gerir o Ecossistema de pagamentos instantâneos Pix. Para tanto, apresentou-se o contexto de sua criação, os aspectos gerais de seu funcionamento e a base normativa para a sua instituição, discutindo-se que normas devem ser observadas pelo BCB para assumir essa dupla de funções. Como resultado do estudo realizado, foi possível concluir que a autoridade regulatória deve observar as regras tipicamente impostas às autarquias pelo Direito brasileiro, no que se refere a modelagem da tarifa cobrada dos participantes do Pix, evitando-se ter o lucro como objetivo final de sua empreitada. Apresentando algumas inferências quanto a possíveis consequências práticas decorrentes da necessária observância dos princípios estabelecidos no art. 7º da Lei n. 12.865/2013, no que couber à condição autarquia de natureza especial, admitiu-se a suficiência do ordenamento jurídico brasileiro vigente para permitir que o BCB de forma equilibrada, segura e previsível regule o mercado de pagamentos de varejo no Brasil ao mesmo tempo em que nele presta parcela de serviços envolvidos com a oferta do Pix.
Entre o Medo e a Luz. 2020: um Diário
Authors: ConfiguraçõesJosé Miguel José Miguel
Published: August 2023

O Diário veio contrariar o enfado, a doença, a moleza do instante, a opressão reinante. Os Diários são animados pelos ventos da viagem. Longas rotas ignotas, “uma pequena luz” na noite do navio, uma candeia no caminho do viajante, a tábua onde escrever cartas de amor e depois a resistência, a percepção do corpo aprisionado, a passagem para o outro lado. Nesse dia em que começamos a escrever todos os dias, somos levados indo e às vezes encantados com a aparição das coisas. Uma corpo-escrito, o exercício da respiração, a observação. Vivo chegado aos ventos do mar. O Zéfro soprando levemente, mas também o Bóreas enrugado nas serranias e promontórios, com o seu modo desgrenhado de tocar as coisas. Olho no alto os céus navegando nuvens. Depois a terra e as suas variações, coisas da água e da arquitectura. Vivo numa terra misteriosa e nós por cá. Lá vou eu à cidade. Tempo para os jornais falados. Não se pode perder nada. O espectáculo é bom. O humano entendimento que acontece nas cidades. As casas, as histórias e um tempo para a meditação. As coisas que se dizem. Não podemos perder nada, não podemos perder nada. O Diário é um vício, às vezes um instante ou uma fulguração e noutro dia o assunto vem mais longo e denso ou difícil de explicar. Deixamo-nos ir. Aos poucos vão-se juntando fragmentos, coisa vista, impressões, uma fala. Reparo que durante o Diário aparecem os pássaros. Fico contente a escrever, numa espécie de visitação a lugares que julgava perdidos e logo se abre uma porta e se levantam imagens, pequenas coisas que podem acontecer durante o silêncio. A música, a página em branco, a tentação.
A soft computing technique based on PSO algorithm and energy management strategy for optimal allocation and placement of PVDG-BES units
Authors: Khenissi Imene , Alkhateeb Nasser , Sellami Raida , Alshammari Gharbi A. , Alshammari Naif A. , Guesmi Tawfik , Neji Rafik
Published: August 2023

In the pursuit of achieving a harmonious equilibrium between electricity production and consumption, the integration of distribution generators (DG) has garnered substantial attention. Yet, the escalated integration of DG systems has given rise to the predicament of reverse power flow, instigating elevated system power losses and voltage profile distortions. Thus, an imperative emerges to judiciously apportion and dimension DG systems, complemented by the incorporation of battery energy storage (BES) systems, as a remedial measure against these challenges. In this scholarly work, we present an innovative approach rooted in a precise energy management strategy (EMS) aimed at the adept allocation and capacity optimization of (PVDG-BES) systems. The study employs a two-step optimization methodology, the former facet of which expounds on the influence of BES system integration on grid power losses and voltage profiles during stable operational conditions. Subsequently, a pioneering optimization technique is formulated in the latter facet to identify the optimal siting and capacity allocation of the aforementioned system based on an optimal EMS framework. The primary focal point of this investigation is the minimization of total power losses. Validation of our proposition is conducted on the IEEE 14-bus standard system, incorporating the particle swarm optimization (PSO) algorithm. Simulation outcomes incontrovertibly affirm the efficacy and robustness of the proposed EMS, yielding substantive reductions in power losses and noteworthy enhancements in voltage profile integrity. Notably, the implementation of EMS leads to a remarkable 31% reduction in total power losses as compared to the initial scenario, prior to the amalgamation of PVDG-BES components. In sum, this study epitomizes a comprehensive strategy for fortifying power grid efficiency by orchestrating the symbiotic interplay of distribution generators and battery energy storage systems through an adept energy management paradigm.
Комптоновское рассеяние двух фотонов атомным ионом
Authors: Хоперский А.Н. , Надолинский А.М. , Конеев Р.В.
Published: August 2023

The analytical structure and absolute values of the doubly differential cross section of the Compton scattering of two X-ray photons by a multicharged neon-like atomic ion are theoretically predicted
Моделирование эквивалентной передаточной функции и импульсного отклика схемы голографии Фурье для высокочастотных голограмм
Authors: Павлов А.В. , Гаугель А.О.
Published: August 2023

An approach for modeling the transfer function and approximating the impulse response in the +1 diffraction order of the 4f holography scheme of the Fourier holography under usage of high-frequency holograms characterized by the presence of an inverse section of the dependence of the local diffraction efficiency on the spatial frequency in the frequency range below the frequency of equality of local amplitudes of the reference spectrum and the reference beam by the model of “Difference of Gaussians” is proposed and justified. The expediency of using, when implementing processing models that involve working only with the global maximum of the circuit response, a transfer function that is equivalent in terms of the minimum mean square error of the impulse response, as providing a more accurate approximation of the impulse response compared to the approximation of the direct transfer function, is shown. The validity of the approach is confirmed by comparing the simulation results with experimental data.
Оптические спектры фотонно-кристаллической структуры со слоями графена
Authors: Елисеева С.В. , Семенцов Д.И.
Published: August 2023

The transformation of the graphene-containing optical spectra photonic-crystal structure with a change in the chemical potential (μ) of graphene is studied. In the period of the structure, one layer is a graphene-containing periodic medium (SiO2/Gr)n , and the second layer is assumed to be made of pure silicon. In the case of unexcited graphene (μ = 0), the absorption in the structure exceeds the reflection and transmission for frequencies outside the photonic band gaps. Within these zones, most of the incident radiation is reflected, and there is no transmission at all. As μ increases outside the band gaps, the absorption decreases in the low-frequency region, and the transmission increases the stronger, the greater μ. In a structure with an inversion defect inside the band gaps, either suppression or significant rearrangement of the defect mode takes place.
Датчик малых перемещений на основе одномерного фотонного кристалла с дефектом
Authors: Сидоров А.И. , Махаева М.В.
Published: August 2023

The results of computer simulation of optical properties of one-dimensional (1D) photonic crystal (PC) with defect, based on the layers Si-SiO2 in near IR range are presented. The optical thicknesses of layers, which form PC, were λ/4, 3λ/4 and 10λ/4. Defect was formed by air gap in the middle of PC. The influence of defect thickness on spectral position of the transmission band of defect was studied. It was shown that the sensitivity on the defect thickness d is in the range of Δλ/Δd = 330-1200 nm/μm and 0.6-0.85 dB/nm, depending on sensor geometry and measurement method. This makes 1D PC with defect promising for the use as sensitive element in sensors of small movements.
Углеродные наночастицы, легированные медью, как двух-модальный нанозонд для люминесцентной и магнитно-резонансной визуализации
Authors: Степаниденко Е.А. , Ведерникова А.А. , Ондар С.О. , Бадриева З.Ф. , Бруй Е.А. , Мирущенко М.Д. , Волина О.В. , Королева А.В. , Жижин Е.В. , Ушакова Е.В.
Published: August 2023

In this work, copper-doped carbon nanoparticles with emission in a wide spectral range and the ability to change the relaxation times of water protons during magnetic resonance imaging were fabricated. A high relaxivity value r1 = 0.92 mM-1∙s-1 was achieved, which is the highest value of r1 for copper nanoparticles, to our knowledge. The suggested carbon nanoparticles are promising two-modal nanoprobes for bioimaging.
Мониторинг локализованного плазмонного резонанса неоднородного ансамбля серебряных наночастиц на границе двух сред
Authors: Старовойтов А.А. , Фандеев А.А. , Никитин И.Ю. , Гладских И.А. , Дададжанов Д.Р.
Published: August 2023

Optical properties of an inhomogeneous ensemble of plasmonic silver nanoparticles obtained by thermal vacuum deposition at the interface between two media as this interface moves relative to the nanoparticles themselves have been studied. The movement was carried out due to thermally stimulated diffusion of nanoparticles into the polystyrene layer and due to the deposition of an additional layer of quartz on a granular film with nanoparticles on a quartz substrate. The frequency shifts of the inhomogeneous plasmon resonance of nanoparticles moving through the interface was to about two tens of nanometers.
Developing a Web-Based Asynchronous Case Discussion Format on Social Media to Teach Clinical Reasoning: Mixed Methods Study
Authors: McQuade Casey N , Simonson Michael G , Ehrenberger Kristen A , Kohli Amar
Published: August 2023

Background

Case-based learning conferences are valuable to trainees, but growing clinical demands hinder consistent attendance. Social media increasingly acts as a venue for trainees to supplement their education asynchronously. We designed and implemented a web-based asynchronous clinical case discussion series on the Twitter social media platform to fill this educational gap.

Objective

The aim of this mixed methods study is to examine the nature of interactions among web-based case discussion participants and assess local attitudes regarding the educational intervention.

Methods

Starting in February 2018, we posted clinical vignettes to a dedicated Twitter account with the prompt “What else do you want to know?” to stimulate discussion. The authors replied in real time when case discussion participants requested additional details. Additional data about the case were posted at regular intervals to the discussion thread to advance the overall case discussion. Participants were asked to explain their reasoning and support their conclusions when appropriate. Web-based engagement was assessed using Twitter Analytics. Participants’ posts were qualitatively analyzed for themes, with special attention to examples of using clinical reasoning skills. A codebook of types of participant posts and interactions was refined iteratively. Local engagement and attitudes at our institution were assessed by surveying internal medicine trainees (n=182) and faculty (n=165) after 6 months.

Results

Over a 6-month period, 11 live case discussions were engaged with by users 1773 times. A total of 86 Twitter profiles spanning 22 US states and 6 countries contributed to discussions among participants and the authors. Participants from all training levels were present, ranging from students to faculty. Interactions among participants and the case moderators were most commonly driven by clinical reasoning, including hypothesis-driven information gathering, discussing the differential diagnosis, and data interpretation or organization. Of 71 respondents to the local survey, 29 (41%) reported having a Twitter account. Of the 29 respondents with Twitter accounts, 17 (59%) reported participating in the case discussions. Respondents agreed that case participation increased both their clinical reasoning skills (15/17, 88%) and clinical knowledge (13/17, 76%).

Conclusions

A social media–based serialized case discussion was a feasible asynchronous teaching method for engaging web-based learners of all levels in a clinical reasoning discussion. Further study should examine what factors drive trainee participation in web-based case discussions and under what circumstances asynchronous discussion might be preferred over in-person teaching activities.
Developing a Web-Based Asynchronous Case Discussion Format on Social Media to Teach Clinical Reasoning: Mixed Methods Study (Preprint)
Authors: McQuade Casey N , Simonson Michael G , Ehrenberger Kristen A , Kohli Amar
Published: August 2023

BACKGROUND

Case-based learning conferences are valuable to trainees, but growing clinical demands hinder consistent attendance. Social media increasingly acts as a venue for trainees to supplement their education asynchronously. We designed and implemented a web-based asynchronous clinical case discussion series on the Twitter social media platform to fill this educational gap.

OBJECTIVE

The aim of this mixed methods study is to examine the nature of interactions among web-based case discussion participants and assess local attitudes regarding the educational intervention.

METHODS

Starting in February 2018, we posted clinical vignettes to a dedicated Twitter account with the prompt “What else do you want to know?” to stimulate discussion. The authors replied in real time when case discussion participants requested additional details. Additional data about the case were posted at regular intervals to the discussion thread to advance the overall case discussion. Participants were asked to explain their reasoning and support their conclusions when appropriate. Web-based engagement was assessed using Twitter Analytics. Participants’ posts were qualitatively analyzed for themes, with special attention to examples of using clinical reasoning skills. A codebook of types of participant posts and interactions was refined iteratively. Local engagement and attitudes at our institution were assessed by surveying internal medicine trainees (n=182) and faculty (n=165) after 6 months.

RESULTS

Over a 6-month period, 11 live case discussions were engaged with by users 1773 times. A total of 86 Twitter profiles spanning 22 US states and 6 countries contributed to discussions among participants and the authors. Participants from all training levels were present, ranging from students to faculty. Interactions among participants and the case moderators were most commonly driven by clinical reasoning, including hypothesis-driven information gathering, discussing the differential diagnosis, and data interpretation or organization. Of 71 respondents to the local survey, 29 (41%) reported having a Twitter account. Of the 29 respondents with Twitter accounts, 17 (59%) reported participating in the case discussions. Respondents agreed that case participation increased both their clinical reasoning skills (15/17, 88%) and clinical knowledge (13/17, 76%).

CONCLUSIONS

A social media–based serialized case discussion was a feasible asynchronous teaching method for engaging web-based learners of all levels in a clinical reasoning discussion. Further study should examine what factors drive trainee participation in web-based case discussions and under what circumstances asynchronous discussion might be preferred over in-person teaching activities.
Association Between Step Counts and Depressive Symptoms (Preprint)
Authors: Kim Ju-Wan , Jhon Min , Kim Changheon , Lim Bahngtaik , Baek Seon-Hwa , Kang Hee-Ju , Kim Honey , Lee Ju-Yeon , Ryu Seunghyong , Shin Il-Seon , Kim Sung-Wan , Kim Jae-Min
Published: August 2023

BACKGROUND

The use of life-log data in psychiatry can provide valuable insights regarding the effectiveness of treatments for depression.

OBJECTIVE

This cross-sectional transdiagnostic study investigated the relationship between daily step counts, measured via an actigraph, and depressive symptoms in a large population of 3021 Asian individuals.

METHODS

Depressive symptoms were measured using the PHQ-9 questionnaire, and actigraphy data were collected using the wGT3X-BT device. Data regarding the number of steps taken by the participants were collected during four different time periods. The participants wore the actigraphy device continuously for 7 days, from 18:00 on the day on which they provided study consent until 6:00 7 days later.

RESULTS

Among the participants, 1,093 exhibited depressive symptoms while 1,928 did not. Significant differences in mean step counts were observed between the symptoms and no-symptoms groups during each time period, except for 0:00–6:00. The average step count data revealed that the severity of depressive symptoms was significantly and negatively correlated with the number of steps taken during the 06:00–12:00, 12:00–18:00, and 18:00–24:00 periods.

CONCLUSIONS

Individuals with depressive symptoms had significantly lower mean step counts than those without depressive symptoms, indicating that there is a relationship between physical activity and mood state.
Multimedia Planning Strategies as a Tool for International Journalism and Alternative Media Studies
Authors: Dmitriev Oleg , Hejase Hussin J.
Published: August 2023

News development is currently affected by digitalization. Therefore, media scholars using digital means to cover the news must develop the so-called “multimedia mindset” among professional journalists and media students. It is not enough to teach the technology—the scholars have to embrace new journalism tools to incorporate them with the story planning activities. This article aims to look into how the aforementioned planning activities are used in the curriculum for Russian media students and professionals in the field of international journalism. The paper is qualitative and descriptive based on secondary data reported in hybrid written media. Also, this research uses a case study dealing with a proposed new program “International News Production” a track within the Contemporary Journalism Master program including alternative media at the High School of Economics Media Institute in Moscow. The findings of this study shed light on the skills needed in new alternative media. Students undergoing the proposed new program in alternative and international media enhance their professional skills and qualifications while experiencing Russian culture. Graduates from the program shall have ample opportunities to pursue careers in various areas of the media industry, including visual journalism, data journalism, storytelling, production, and newsroom management at various international newsrooms. Teaching new alternative media methods can be easily projected to the work with practicing journalists in news channels and information agencies.
Research Progress and Prospect of Marine Antifouling Coatings
Authors: Yu Xincheng , Wang Jin , Kou Mingzhe , Shi Zongyi , Yu Yingshui
Published: August 2023

Marine biological pollution refers to activities such as a large number of barnacles, algae and other organisms or microorganisms gathering and damaging ships or other marine industries. Among them, the most effective way is to use degradable materials as the substrate and add antifouling agents that can destroy fouling organisms. Traditional marine antifouling coatings release toxic substances with broad spectrum, such as cuprous oxide and organotin, so as to achieve effective antifouling. However, with the adverse effects on the marine environment, it is a long way to go to study and prepare environment-friendly antifouling agents. This paper mainly introduces the traditional degradable materials PCL, PLA, etc., and also introduces the current low-toxic antifouling agent DCOIT composite materials and new natural antifouling agents, etc.
Inactivation of Salmonella enterica, Escherichia coli O157:H7, and Campylobacter jejuni in a Restructured Beef Jerky Developed for Production in Ethiopia
Authors: Brown Jessica , O'Bannon Taylor , Havelaar Arie , Carr Chad , Kowalcyk Barbara B. , Scheffler Jason M.
Published: August 2023

Drying is one of the oldest methods of food preservation, involving the addition of salt and removal of water to generate a shelf-stable and nutrient-dense product. Pathogens have demonstrated the ability to adapt during a slow drying process, making them more resistant to dehydration and heat treatment. In Ethiopia, an inconsistent electrical grid makes refrigeration unreliable, making dried meat products desirable to consumers. The main dried beef product, qwanta, is very labor intensive to produce. It is therefore not well suited for commercial production and drying at ambient temperatures limits inactivation of pathogenic bacteria. This study quantitatively evaluated the inactivation kinetics of foodborne pathogens during the drying of a restructured beef jerky product produced by a heat treatment that could be applied in anEthiopian butcher shop. A secondary objective was to evaluate effects of including 15% (w/w) pureed dates or raisins into the formulation. Challenge studies were performed on 5 serotypes of Salmonella enterica, 3 strains of Escherichia coli O157:H7, and 3 strains of Campylobacter jejuni. Meat formulations were inoculated with stationary phase cultures, formed into strips, and dehydrated for 6 h in a home-style dehydrator. Samples were weighed pre- and post-drying, plated for enumeration of challenge strains each hour, and water activity (aw) was measured at each sampling interval. Nonlinear predictive models were fit to the inactivation data, revealing an inverse sigmoidal curve for S. enterica and concave downward curves for E. coli and Campylobacter. Salmonella and E. coli were reduced 4.56 ± 0.35 and 6.27 ± 0.69 log (CFU/g),respectively, after 6 h of drying, while Campylobacter was reduced below the limit of detection (>4.32 log [CFU/g] reduction) after 3 h of drying. Including dates (15% w/w) into formulation improved the reduction of S. enterica by 0.63 log (CFU/g) compared to the control (P=0.02), whereas the addition of raisins showed a non-significant improvement (0.50 log CFU/g; P=0.07). Modified processes to improve the safety and extend the shelf life of animal-sourced foods in Ethiopia can reduce the incidence of foodborne disease and provide consumers with a more convenient and accessible source of protein as well as reduce food waste. These predictive models and validation studies may be useful for Ethiopian and US jerky producers, giving them the ability to more accurately assess the microbial risk of their products
La comunicación académica en un mundo de plataformas
Authors: Giordanino Eduardo Pablo
Published: August 2023

Se tratan las problemáticas actuales de las bibliotecas universitarias en relación con los datos y metadatos de las revistas científicas, considerando los estilos de comunicación en la sociedad de la información y las economías basadas en el conocimiento. A partir del crecimiento exponencial de la información científica, se reseñan los desafíos de la profesión y la misión de los bibliotecarios desde el período de entreguerras, el surgimiento del control bibliográfico y la aparición del MEMEX en 1945, con los problemas relativos al registro de la información de las revistas. Se describe la comunicación científica actual considerando el crecimiento de China como líder en publicaciones científicas y patentes, y la situación de América Latina. Finaliza con ejemplos de buenas prácticas y sugerencias de para mejorar las revistas científicas.
Actualización automatizada de los catálogos bibliográficos en el SIBIUNAM gestionados por el SIGB Koha
Authors: Manilla Hernández Lluvia Alejandra , Contreras Barrera Marcial
Published: August 2023

Los procesos de catalogación, clasificación y registro de acervos bibliográficos se realizan de manera centralizada en el catálogo LIBRUNAM, por el Departamento de Procesos Técnicos de la DGBSDI y por el personal del Sistema Bibliotecario de la UNAM; como consecuencia de la centralización de la información, surge la necesidad de actualizar los catálogos locales de las bibliotecas gestionados por el SIGB Koha, esta actualización debe realizarse a través de métodos automatizados, como el nombrado actualización semanal.
De un curso en línea a una verdadera experiencia de aprendizaje
Authors: Vadillo Guadalupe
Published: August 2023

Docentes e instituciones tienen la posibilidad de tomar decisiones que afectan el tipo de producto educativo que proponen a sus estudiantes y que incluyen las dimensiones de recursos, conexión con el mundo real e interacción con elementos que contribuyen que se logre aprender. El propósito de este artículo es aportar un marco de diseño de experiencias de aprendizaje en línea que haga uso de modelos de aprendizaje activo (AA) e impulse el involucramiento continuo por parte del estudiante, así como un procedimiento para su evaluación. Parte de la idea o necesidad, la definición de la estrategia, la arquitectura, la valoración de calidad y la evaluación auténtica de la experiencia de aprendizaje a través de un pilotaje previo a su uso.
Alerta Documental
Authors: Sánchez Ambríz Gerardo
Published: August 2023

La Revista Universitaria Digital en Ciencias Sociales: RUDICS, incluye en este fascículo una -Alerta Documental- diseñada especialmente para el fortalecimiento de los procesos de enseñanza – aprendizaje y el propio enriquecimiento cognitivo de toda la comunidad lectora de la revista.
El contenido incluye un conjunto de definiciones y referencias bibliográficas (Estilo APA) actualizadas que contienen artículos científicos relacionados con el tema: Responsabilidad Social Organizacional, evaluados con un índice de factor de impacto y aparecen citados en bases de datos especializadas (Dialnet y ScienceDirect); así como libros en formatos digitales e impresos, disponibles en el Sistema Bibliotecario de la Universidad Nacional Autónoma de México.
Logrando tus metas, la movilidad académica en la Facultad de Medicina
Authors: Durante Monyiel Irene
Published: August 2023

The objective of this article is to describe the improvement strategies that the UNAM School of Medicine (FacMed), through the MAVI (Academic Mobility and Interinstitutional Linkage Unit), has implemented throughout its administration from 2016 to 2022. The situation of mobility in the Faculty of Medicine of the UNAM is discussed, as well as the personal and institutional benefits derived from academic mobility. Although academic mobility is an expensive situation that requires financing, the FacMed generated strategies and accompaniment with which mobility processes were carried out in its community. In addition, the programs that were created during the COVID-19 pandemic are described, in response to the continuous needs for internationalization, all of them adapted to geographical mobility limitations, such as the Virtual Language Exchange, to generate bilingual practices. Likewise, the Meet&Greet in Health Science Internationalization Program, an event where students from the UNAM Faculty of Medicine met with students from other higher education institutions, to discuss various research topics in health sciences. It should be noted that academic mobility at FacMed is not exclusive to the student community, since some teachers were also advised to be part of the UNAM program of special activities for inter-institutional cooperation (PAECI), which facilitated their stay or travel. out of the country.
Keywords: Academic mobility; internationalization; curriculum development; networks; higher education institutions.
"Logra tu meta": Estrategia de evaluación formativa para el ingreso al posgrado y el desarrollo profesional en medicina
Authors: Macedo de la Concha Lilia
Published: August 2023

Achieve your goal” is an evaluation Project that is part of the “Program for the Academic Strengthening of the Medical Pasantei in Rural Areas”. It considers the elaboration of objective exams, which allow the participant to self-evaluate their learning given their formative condition. The exams were designed from clinical cases and their corresponding reagents, based on the structure and contents of the electronic books “FundamentalSS”. From 2018 to 2022, general practitioners and specialists prepared 383 cases and 7,059 items from various medical areas. Some of these have been used in the design of seven exams that were applied to 1,899 participants between 2019 and 2022.
Achieve your goal is a project in development, promotes self-assessment of learning and its strengthening, which will guide interns and graduates in their preparation for admission to a medical specialty or another postgraduate, as well as for their profesional development. This project stands out for its solid methodology and is an effort carried out by FM-UNAM with the support of the Gonzalo Rio Arronte Foundation, with the purpose of promoting health care for the Mexican population.
Keywords: Formative evaluation; profesional development; medical interns; social service; ENARM.
Unidad de microscopía de la Facultad de Medicina
Authors: Sánchez-Cervantes Ivonne Grisel
Published: August 2023

The development of microscopy has allowed mankind to explore what is hidden to the naked eye and has revolutionized the way scientific and medical research is carried out. In the field of medicine, microscopy has become an indispensable tool for the timely diagnosis of diseases, as well as to demonstrate processes at the cellular and subcellular level using new drugs, among many other applications.
The Microscopy Unit of the Faculty of Medicine of the National Autonomous University of Mexico (UMIC-FM) makes available to the scientific and academic community its specialized technology and advanced microscopy equipment to contribute to the growth and development of scientific, educational and diagnostic activities for the benefit of society.
Keywords: Core facilities; advanced microscopy;pathological diagnostics; biomedicine
Deep Blue Discoveries: Advancements in Fish Detection and Species Taxonomy Using Deep Learning in the Subaquatic Realm
Authors: Swetha  , Sreerambabu  , Riyaz Mohammed , Kalidasan
Published: August 2023

Abstract: The Deep Learning Based Underwater Fish Detection and Species Classification project employs deep learning methodologies to accurately detect and classify underwater fish species using a dataset consisting of diverse fish images captured from different underwater locations. The project utilizes a Region-based Convolutional Neural Network (R-CNN) to extract image features, ensuring precise species identification. The model's performance is evaluated using accuracy metrics to assess its effectiveness in fish detection and species classification. This project holds practical implications for the field of fisheries management and conservation by enabling accurate identification and classification of fish species in underwater environments. Moreover, the project's outcomes have the potential to find applications in marine biology and ecology, serving as a valuable tool for studying fish behavior and ecological dynamics within their natural habitats. The project's successful implementation underscores the transformative potential of deep learning techniques in the domain of computer vision, specifically in tasks such as image classification, segmentation, and object detection. In conclusion, the Deep Learning Based Underwater Fish Detection and Species Classification project employs advanced deep learning techniques to accurately identify and categorize various fish species in underwater environments. The project's diverse dataset, encompassing fish images captured from different underwater locations, enhances its significance for the fields of fisheries management and conservation. The project's outcomes have the potential to significantly contribute to our understanding of underwater ecosystems and support endeavors aimed at their protection and preservation
A High Accuracy Recommendation System for the Rubber Industries: Integrating Collaborative Filtering with Multi-layer Perceptron Classifier
Authors: Sreerambabu Dr. J. , Rajkumar Mr. D. , Santhosh Mr. N. , Hariharasudhan Mr. C.
Published: August 2023

Abstract: Collaborative filtering is a widely used method in Machine Language to discover relationships between data. It facilitates recommendation systems that find similarities between user data and items, recommendation system playing a crucial role in various industries. Multilayer perceptron classifier used in our model, a connection with neural networks that performs well in regression and achieves high accuracy in classification tasks. When compared to other neural network architectures like convolution neural network (CNN), recurrent neural network (RNN), auto encoder (AE), and generative adversarial network (GAN), MLP remains a fundamental approach. Collaborative filtering involves multiple users, viewpoints, and data sources collaborating to classify information or patterns and recommend items that similar users might like. Instead of recommending items based on their features, we group users into neural networks with similar preferences and suggest items based on their classifier's preferences.
College Hostel Inventory Management System
Authors: Sreerambabu Dr. J. , Riyaz Mr. M. Mohammed , Rajkumar Mr. D. , D Mr. Tamilarasan
Published: August 2023

Abstract: The Hostel Inventory Management System introduces an innovative web and Android application to revolutionize hostel inventory operations, maximizing efficiency, streamlining processes, and enabling data-driven decision-making. The userfriendly interface empowers administrators to manage inventory seamlessly, with real-time data recording and transparent stock management. The manual mess bill calculation is simplified using distribution reports, reducing errors, and enhancing billing accuracy, and resident satisfaction. Comprehensive reporting on purchases, distributions, and stock levels provides valuable insights for optimized purchasing decisions and efficient resource allocation. With exceptional operational efficiency and accuracy in mess bill calculations, this system elevates hostel performance through cost optimization and resident satisfaction. It represents a well-crafted application, prioritizing efficiency, accuracy, and data-driven decision-making for modern hostel inventory management.