bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral Care Management of Head and Neck Cancer Patients at Hospital Universiti Sains Malaysia: A 7-Year Retrospective Study
Authors:   School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia, Chew Huikai , Mokhtar Kasmawati ,   School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia, Beh Yew Hin ,   School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia,   Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia, Wan Zainon Wan Mohd Nazri ,   Department of Nuclear Medicine, Radiotherapy and Oncology, Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia, Ariffin Azirrawani ,   School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Published: June 2022

Head and neck cancer patients require oral assessment and management prior, during and after cancer treatment to minimise oral complications. Hence, this study aimed to evaluate sociodemographic data, oral health management, oral complications derived from cancer treatment, time frame in completing dental treatment and association between oral management and complications. Purposive record sampling of head and neck cancer patients who completed radiotherapy and/or chemotherapy at Hospital Universiti Sains Malaysia (HUSM) from 2011 to 2017 were reviewed. A checklist was used to record the data and analysed using descriptive statistics and Pearson Chi-square test. A number of 194 patient records were reviewed with majority were Malays (88.1%), males (61.3%) with the mean age of 57.18 years old. Only 21% of the patients had oral assessment prior to cancer treatment. About 84% of the referred patients were dentally fit within 1 month. Mucositis and fungal infections were the most prevalent complications. The relationship between oral assessment prior to cancer treatment and oral complications was not significant (p = 0.134). Despite the insignificant association due to several limitations, oral assessment and management prior, during and after cancer therapy are recognised as crucial for improving quality of life. A standard institutional operating procedure is recommended to improve patient care.
Patterns of Paediatric Dental Treatment Under General Anaesthesia: A Retrospective Study
Authors:   Faculty of Dentistry, Universiti Teknologi MARA, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia, Mohamad Shukry Siti Umairah , Mohd Zaid Nurul Aqilah Aisyah ,   Faculty of Dentistry, Universiti Teknologi MARA, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia, Hussein Alaa Sabah ,   Centre of Paediatric Dentistry and Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia, Hamzah Siti Hajar ,   Centre of Paediatric Dentistry and Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia,   Faculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, 119085 Singapore
Published: June 2022

This retrospective study aimed to evaluate patterns of comprehensive dental treatment under general anaesthesia (GA) for healthy children in Universiti Teknologi MARA, Malaysia. The treatment records of healthy paediatric patients who received dental treatment under GA from February 2017 to January 2021 were reviewed. The patients were divided into two groups: (1) less than 6 years old and (2) 6 to 16 years old. Patients’ characteristics were summarised using descriptive statistics while an independent t-test was applied to investigate the influence of “age group” on treatment duration, number of procedures and use of various restorative materials. A total of 125 paediatric patients (67 boys and 58 girls) were included. The patients’ mean age at the time they underwent GA was 5.77 ± 1.94 years old and the average duration of dental treatment was 62.58 minutes. There was a significant difference in the duration of treatment between the two age groups (p < 0.05). Tooth extraction was the most dental procedure performed (63.31%). The 6 to 16 years old group had a significantly shorter treatment duration (p < 0.05). However, no significant differences were found in all procedures (extraction, restoration, preventive and pulp therapy) and the utilisation of composite, glass ionomer cement (GIC) and compomer in both groups. The use of stainless steel crown (SSC) restorations was significantly higher in the less than six years old group (p < 0.05). Most of the dental procedures performed under GA on healthy children were extraction procedures. Children less than six years of old had a longer treatment duration under GA. Composite restorations and SSC were more frequently used in primary dentition.
Stavovi studenata Sveučilišta u Osijeku prema online učenju tijekom potpunog zatvaranja uslijed epidemije COVID-19
Authors: Jurlina Juraj , Papo Demian , Potlimbrzović Hrvoje
Published: June 2022

Zbog pandemije bolesti COVID-19 uzrokovane virusom SARS-CoV-2, u proljeće 2020. godine u Republici Hrvatskoj nastupilo je potpuno zatvaranje koje je uključivalo i mjeru obaveze prelaska nastavnog procesa na svim razinama obrazovanja iz učioničke nastave u nastavu na daljinu. Obilježja koja je učenje u visokom obrazovanju poprimilo tijekom potpunog zatvaranja odgovaraju obilježjima karakterističnima za online učenje. S ciljem utvrđivanja stavova studenata Sveučilišta Josipa Jurja Strossmayera u Osijeku prema online učenju i čimbenika tih stavova, proveli smo kvantitativno istraživanje. Podatke smo pritom prikupljali metodom ankete na prigodnom uzorku (N = 327) putem interneta. Rezultati su pokazali da studenti imaju blago negativan stav prema online učenju, s tim da su pozitivnijeg stava bili studenti koji su se prije epidemije učestalije koristili alatima za online učenje. Primjenom modela prihvaćanja tehnologije potvrdili smo indirektnu povezanost percipirane lakoće korištenja alatima za online učenje i stava prema online učenju s jakim efektom medijacije percipirane korisnosti online učenja.
A reflective multiple case study approach to understanding partner relationships within the context of community engagement at Rhodes University
Authors:   , Bobo Azola Benita Dorothea
Published: June 2022

Using a social constructivist approach, within the social action model of community psychology, this research interrogates the features of successful community engagement partnerships that exist within the context of higher education. It draws on the co-management model that the Rhodes University Community Engagement (RUCE) division proposes, where partnerships are seen to be mutually beneficial. This research further interrogates whether the principles of community engagement that RUCE propose play out in reality, and whether systems of power are deconstructed, in working towards more equitable engagements. Drawing on the Early Childhood Development (ECD) Residence Programme for case studies, this research used a reflective multiple case study design in attempting to answer the research question. Four partner groups (i.e., 4 community partners and 4 community engagement representatives) were selected for this research. Each participant was interviewed twice (with a 6-month time gap) and also participated in two focus group discussions. Thematic analysis was used to analyse the findings. In taking a social justice approach, it can be argued that RUCE has made strides towards forming collaborative partnerships based on the ethics of ubuntu and aspects of transformative learning, which may lead to the decolonisation of higher education. However, critical engagement with the research findings suggests that in many cases the principles that RUCE propose are aspirational. More work needs to be done with both students and community partners to develop the kinds of partnerships that RUCE aspires to. This research provides valuable insight into how carefully managed community engagement partnerships in higher education have the potential to contribute to the transformation agenda of higher education institutions, while promoting equitable societies.
The role of women entrepreneurship antecedents in supporting social and economic well-being
Authors: Dewi Rina , Eliyana Anis , Anwar Aisha
Published: June 2022

One way to support sustainable development is to put concern on women empowerment. The role of women in a society is essential, yet often treated unfairly. This study focuses on looking at the aspects that can determine the success of entrepreneurship as a form of women entrepreneurship. Additionally, the effect of women entrepreneurship on social and economic well-being is also investigated. The study took a quantitative approach and employed a survey method on a total of 406 members of Setia Bhakti Wanita cooperative in Indonesia. STATA 14 statistical software was used to analyze the data. The results of this study indicate that access to micro-loans has the highest impact on women entrepreneurship (path coefficient 0.43), followed by social environment support (path coefficient 0.32), and entrepreneurial education (path coefficient 0.13). Furthermore, women entrepreneurs have a more favorable impact on economic well-being (path coefficient 0.93), as evidenced by better access to health service, than social well-being (path coefficient 0.89) that is shown from better social relationship with the nearest community. This study offers solid evidence-based recommendations for women’s empowerment in Indonesia using proper entrepreneur organization channels.
AcknowledgmentThe authors thank to Faculty of Economics and Business, Airlangga University, Indonesia and the Setia Bhakti Women Cooperative East Java Indonesia.
ANKARA OYUN HAVALARININ KISA TARİHİ
Authors: Satır Ömer Can
Published: June 2022

Yapılan bu çalışma günümüzde popüler kültürün önemli bir nesnesi haline gelen Ankara oyun havaları pratiklerinin yakın geçmişine odaklanırken Cumhuriyetten bugüne Başkentin geçirdiği eğlence hayatı deneyimini siyasal kırılmalar ışığında değerlendirmeye açacaktır. Buna göre Başkent Ankara’nın eğlence yaşamını kurucu unsur Cumhuriyet dönemi, Demokrat Partiyle gelişen iç göç süreci, 12 Eylül sonrası piyasa ekonomisinin dayattığı yerli kültür endüstrisi ve 90’lı yıllarda kentin periferisine yerleşerek 2000’lerden itibaren yeni “Ankaralı” demografisi üzerinde şekillenen gazino-pavyon kültürü gibi belirli dönemler üzerinden incelemek mümkündür. Tüm bu süreçlere paralel olarak tarihsel temelleri Seymenlik ile Orta Anadolu müzik geleneğine kadar uzanan Ankara merkezli oyun havası pratiklerini etkileyen Refik Başaran ve Bayram Aracı gibi aktörlerin yanında eğlence ortamlarının dönüşümü bu araştırmada tartışmaya açılan önemli konuların başında gelmektedir. Merkez-çevre diyalektiği üzerinden müzik-içki-kadın üçgeninde oda sohbetleriyle gelişen oyun havası pratikleri 1960’lı yılların sonundan itibaren Başkentte yükselen gece hayatına girerek kalıcı bir iz yaratmaya başlamıştır. 1980 sonrası dönüşen Türkiye sosyolojisinin bir izdüşümü olarak el değiştiren gazinolarda ortaya çıkan arabesk etkinin Ankara havalarını etkilemesiyle yeni Ankaralı demografisinin eş zamanlı gelişimi oyun havalarının yerel bir sound eşliğinde icrasına imkân tanımıştır. Yaşanan tüm bu gelişmeler Ulus, Cebeci, Maltepe hattında onlarca Ankara oyun havası mekânı yaratırken içinde bulunduğumuz küresel çağda kadim bir gelenek aktarımının devam ettiğini kanıtlamaktadır.
TASVİRLERLE İSA’NIN MUCİZELERİNE SAHNE OLMUŞ BİR DENİZ: CELİLE
Authors: Demir Hatice
Published: June 2022

Bu çalışmada, İsa’nın İşleri siklusu içerisinde yer alan mucize sahnelerinden Celile Denizi’nde gerçekleşmiş olanlar çalışılmıştır. Çalışma birkaç alt başlık altında ele alınmıştır. Giriş ve ikinci bölümlerde Celile Denizinin tarihi geçmişi ve isimleri üzerinde durulmuştur. Üçüncü bölümde kısaca Celile Eyaleti’nde gerçekleşen İsa’nın İşleri ele alınmıştır. Dördüncü bölüm çalışmanın ana hatlarını oluşturmuştur. İsa’nın Celile Denizi bağlantılı mucizelerinin Hıristiyan tasvir sanatındaki yansımaları ele alınmıştır. Sahneler, Kitab-ı Mukaddes’e bağlı kalınarak kronolojik bir sıralama ile incelenmiştir. Bu bağlamda ele alınan sahneler; İsa’nın Fırtınayı Dindirmesi, İsa’nın Cinlileri İyileştirmesi, İsa’nın Su Üzerinde Yürümesi/Aziz Petrus’un Celile Denizi’nden Kurtarılması, İsa’nın Dirilişi Öncesi Mucizevi Balık Tutma ve İsa’nın Dirilişi Sonrası Mucizevi Balık Tutma şeklindedir. Değerlendirme ve sonuç bölümlerinde, sahnelerin Celile Denizi ve birbirleri ile olan bağlantıları tartışılmıştır.
Электронномикроскопическая характеристика регенерационного гистиона на 12 сутки заживления ишемизированной раны кожи мышей без лечения и под воздействием полидезоксирибонуклеотидов
Authors:   институт «Медицинская академия имени С.И. Георгиевского» ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского», кафедра хирургии №2, Барановский Юрий ,   институт «Медицинская академия имени С.И. Георгиевского» ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского», кафедра гистологии и эмбриологии, Шаповалова Елена , Барсуков Николай , Ильченко Федор , Купша Елена , Демьяненко Инна
Published: June 2022

Изучение ультраструктурной характеристики компонентов регенерационного гистиона на 12 сутки после введения полидезоксирибонуклеотидов (PDRN) в ишемизированную рану кожи.
Патологоанатомические и патогенетические аспекты фибрилляции предсердий
Authors:   ФГБОУ ВО «Орловский государственный университет имени И.С. Тургенева», Барсуков Владимир , Вишневский Валерий ,   ФГБОУ ВО «Орловский государственный университет имени И.С. Тургенева», Иванов Александр ,   ФГБОУ ВО «Курский государственный медицинский университет»
Published: June 2022

Фибрилляция предсердий (ФП) - частый вид аритмий, проявляющаяся нарушениями электрическая активность миокарда предсердий, что резко снижает их систолическую функцию. Это сопровождается нарушениями функции желудочков сердца и значительными гемодинамическими расстройствами, часто - тромбозом ушек предсердий с эмболизацией ветвей легочных артерий и ветвей аорты.
Топографо-анатомические особенности лимфангиоархитектоники молочной железы: предпосылки к обоснованию лимфогенного метастазирования рака молочной железы
Authors:   НИИ морфологии человека им. академика А.П. Авцына, ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Мнихович М. , Романов А. ,   НИИ морфологии человека им. академика А.П. Авцына, ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Безуглова Т. ,   НИИ морфологии человека им. академика А.П. Авцына, ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Ширипенко И. ,   Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, Сидорова О. ,   Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, Лозина М. ,   Российский национальный исследовательский медицинский университет имени Н. И. Пирогова
Published: June 2022

Данные статистики за 2012 год сообщают о 1,7 миллионах случаев заболевания раком молочной железы. Смертность от рака молочной железы достигает приблизительно 521,900 случаев, причём не менее чем у 70% умерших были обнаружены метастазы. Известно, что возраст является фактором риска развития рака молочной железы у женщин.
Оценка эффективности профилактики йододефицита у школьников г. Курска
Authors:   Кафедра эндокринологии, Курский государственный медицинский университет, Савельева Жанна , Чуева Татьяна ,   Кафедра анатомии человека, Курский государственный медицинский университет, Рассказов Константин ,   Кафедра анатомии человека, Курский государственный медицинский университет
Published: June 2022

Щитовидная железа является главной железой эндокринной секреции. Ее гормоны (Т3, Т4) выделается непосредственно в кровь, регулируя синтез белка, механизм тканевого дыхания, рост, клеточную дифференцировку, и другие процессы основного обмена. Поэтому очень важно уже с ранних лет вести профилактику йодного дефицита. Главной целью данного исследования был анализ использования йодированной соли, как способа эффективной профилактики йодного дефицита у школьников.
Гибридное образование на кафедре гистологии, цитологии и эмбриологии Смоленского государственного медицинского университета в условиях пандемии
Authors:   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования ", Степанова Степанова Ирина ,   Смоленский государственный медицинский университет",   Министерства здравоохранения Российской Федерации, Боженкова Мария ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Николаева Ирина ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Ноздрачёв Алексей ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Калинина Олеся ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Каргина Анна ,   Кафедра терапевтической стоматологии, федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Ильина Оксана ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Разгильдяева Марина ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Ильин Дмитрий ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации, Ковалёва Елизавета ,   Кафедра гистологии, цитологии и эмбриологии федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" Министерства здравоохранения Российской Федерации
Published: June 2022

Обучение студентов - это крайне сложный и ответственный процесс, особенно в медицинском ВУЗе. Он должен включать в себя как самостоятельную, так и аудиторную работу студента, что формирует необходимый багаж знаний и практических навыков.
Иннервация нервных стволов конечностей человека: по материалам исследований Давида А. Сигалевича
Authors:   Кафедра анатомии человека, Курский государственный медицинский университет, Харченко Владимир , Иванов Александр ,   Кафедра анатомии человека, Курский государственный медицинский университет, Рязаева Лидия ,   Кафедра анатомии человека, Курский государственный медицинский университет, Никишина Нина ,   Кафедра анатомии человека, Курский государственный медицинский университет
Published: June 2022

В настоящей статье показаны результаты научных исследований по иннервации крупных нервных стволов конечностей полученных, Давидом Ароновичем Сигалевичем, д.м.н., профессором, заведующим кафедрой нормальной анатомии Курского государственного медицинского института с 1966 г. по 1986 г.
Методика создания обучающего видео в практике учебного процесса кафедр морфологического профиля
Authors:   Кафедра анатомии человека, Курский государственный медицинский университет, Черноморцева Елена , Тутова Виолетта ,   Лечебный факультет, Курский государственный медицинский университет, Черноморцев Станислав ,   Педиатрический факультет, Курский государственный медицинский университет, Зимина Олеся ,   Лечебный факультет, Курский государственный медицинский университет, Звягинцев Артем ,   Лечебный факультет, Курский государственный медицинский университет, Лунева Мария ,   Лечебный факультет, Курский государственный медицинский университет, Котенко Илья ,   Лечебный факультет, Курский государственный медицинский университет
Published: June 2022

Статья освещает основные проблемы формирования видеобанка обучающих пособий для кафедр морфологического профиля с целью повышения качества обучения студентов медицинских вузов. Представлен опыт кафедры анатомии человека Курского государственного медицинского университета (КГМУ) в разработке видеопособия по анатомии жевательной мускулатуры.
On the convergence of dynamic quasiperiodic systems
Authors:   St. Petersburg State University, Strekopytov Sergey A. , Strekopytova Maria V. ,   St. Petersburg State University
Published: June 2022

The convergence problem for non-autonomous systems of differential equations with a quasiperiodic right-hand side in an independent argument is considered. It is proposed to replace the consideration of the set of solutions of the system of differential equations under consideration by considering the movements of a dynamic quasi-periodic system generated by these differential equations. Necessary and sufficient conditions are obtained when a dynamic quasi-periodic system has the convergence property, and a proof is given.
Applied routing problem for a fleet of delivery drones using a modified parallel genetic algorithm
Authors:   St. Petersburg State University, Markelova Anastasia Y. , Allahverdyan Alexander L. ,   St. Petersburg State University, Martemyanov Alexey A. ,   St. Petersburg State University, Sokolova Inga S. ,   St. Petersburg State University, Petrosian Ovanes L. ,   St. Petersburg State University, Svirkin Mikhail V. ,   St. Petersburg State University
Published: June 2022

More and more experts agree that in the near future, most freight traffic will be carried out using automated systems, and of them drone delivery is considered to be the most promising. Drone delivery would benefit by independence from the limitations of transport infrastructure and road conditions and would ensure cargo delivery with rapid turnaround times, as well as a significant reduction of environmental impact. The technical capabilities of unmanned aerial vehicles improve year by year, so the task of coordinating drones and effectively planning routes is relevant and in great demand. The development of such technologies will help reduce transportation costs and improve customer service through faster delivery. This article discusses the applied routing problem for a fleet of drones with limited load capacity for the delivery of heterogeneous goods with the possibility of loading in multiple warehouses from an international optimization competition. The solution includes new approach based on a mixed dimensional parallel genetic algorithm (MDPGA) for finding rational routes for delivering goods to various customers and an assignment problem to reduce the dimension depending on the number of warehouses.
Determining the structure and parameters of the human model subjected to vibration
Authors:   St. Petersburg State University, Tregubov Vladimir P. , Egorova Nadezhda K. ,   St. Petersburg State University
Published: June 2022

This article presents results from an experimental study of the frequency properties of a sitting person. This analysis shows that in order to define the structure and parameters of a human body model, it is necessary to find the only solution to the problem of determining the model parameters. Otherwise, this model cannot be used to build vibration protection systems, which is its main purpose. This problem was solved for a two-mass human model. To do this, the total model mass and although the amplitude-frequency response and input frequency impedance for both solids in the model structure are needed to be known. In addition to this, the influence of multi-articular muscles on the frequency characteristics of a human body is found using mechanical models with an arbitrary number of degrees of freedom. In particular, the possibility of the existence additional antiresonance frequencies on the upper mass is shown.
Statistical analysis of investment attractiveness of China’s regions
Authors:   St. Petersburg State University, Qi Dongfang , Bure Vladimir M. ,   St. Petersburg State University
Published: June 2022

This study is devoted to the application of methods of applied statistics to the study of investment attractiveness of regions of China. Methods of applied statistics are widely used in various engineering research, medicine, economics, sociology, astronomy, ecology, physics, information technology, etc. statistical tools is an integral part of the study. Data taken from the World Bank website and the China Statistical Yearbook. The main topic of this research is: What factors are most strongly associated with investment attractiveness in the economy of modern China? Such a study can only be carried out based on the analysis of economic data, especially in the conditions of the modern digital economy. Consequently, the problem under consideration belongs to the field of applied mathematics. First of all, need to choose a mathematical model and research method. This paper uses the method of regression analysis - one of the most important methods for analyzing economic data. Regression models are mathematical models built from empirical data. Observations (empirical data) are the numerical data on the level of investment in the regions of China, as well as the numerical values of various factors. For each year, a multiple regression model is built using the least squares method, its statistical significance is checked, statistically significant factors are selected (statistically significant coefficients for the factors correspond to them). Calculations are carried out in Excel and SPSS, using subroutines and. Mathematical functions, but at the same time, an algorithm for analyzing the initial data based on a stepwise regression algorithm has been developed, in which only one factor with the least significant coefficient (maximum p-value (t)) is discarded at each step and then an algorithm for choosing the most important factors for investment attractiveness was developed, the essence of this algorithm is that the regression models are compared for each year and how many times each factor was included in the model is calculated algorithms can be attributed to the application of methods informatics in this work. The choice of the most important factors that determine the level of investment attractiveness is made to solve the problem of managing the economy. Attracting investments is important for the effective development of every region, every city, every district. With the receipt of significant investments, it is possible to solve the problems of economic and social development. Determination of the most important factors will make it possible to most effectively solve the problem of managing the economic development of each region, each city, each district.
Lateralization in the visual perception of a potential source of danger in free-ranging steppe marmots (Marmota bobak)
Authors: Demina Irina , Dyomin Alexander , Karenina Karina
Published: June 2022

A variety of vertebrate species display lateralization of visual perception of threat. However, the vast majority of studies were carried out in the laboratory conditions, and little is known about the relevance of this lateralization for animals in their natural environment. The aim of our work was to study lateralized visual perception of potential threat in the steppe marmot. The asymmetric use of visual fields when reacting to an approaching threat was assessed in two wild populations of marmots. The results showed that marmots predominantly used the right eye for threat monitoring. A significant impact of anthropogenic disturbance was found both within and between the populations. The right-sided preference was reduced in animals inhabiting areas with high degree of anthropogenic disturbance. The eye (left/right) a focal individual used for threat monitoring did not influence its flight initiation distance. Contrary to a previous study, our results do not suggest that the use of a particular eye affects the speed of threat assessment.
Hispanic Ethnicity and Social Determinants of Health: Harnessing Data from The Pulmonary Hypertension Association Registry
Authors: Bernardo Roberto J. , de Jesus Perez Vinicio A.
Published: June 2022

Pulmonary arterial hypertension (PAH) is a chronic, progressive, and debilitating disease associated with increased cardiopulmonary morbidity and mortality. Current knowledge is derived from registries and landmark clinical trials, although concern exists that minorities are underrepresented in these datasets, and it remains unknown if there are intrinsic differences in minorities and disadvantaged groups. The Pulmonary Hypertension Association Registry offers a unique opportunity for the understanding of the unique social background of minorities in the United States because it routinely collects information related to socioeconomic factors such as annual income and health care insurance. Furthermore, representation of Hispanic patients may be slightly higher than in other US-based registries.

In this review, we discuss the interplay between biologic, socioeconomic, and racial or ethnic factors in PAH, with special emphasis on the Hispanic population. We describe the unique socioeconomic profile of Hispanic individuals and propose next steps to improve representation and fight inequality for Hispanic patients with PAH.
LOS EJERCICIOS ESPIRITUALES: APROXIMACIÓN DESDE MICHEL FOUCAULT Y FRANCESC TORRALBA
Authors:   Pontificia Universidad Javeriana., Velásquez Camelo Edgar Enrique
Published: June 2022

Los ejercicios espirituales, desde la propuesta de Michel Foucault en La hermenéutica del sujeto, son prácticas orientadas al cultivo de la vida interior ligadas de forma concreta a la existencia cotidiana de la persona. De este modo, y desde la propuesta de Francesc Torralba en Inteligencia espiritual, es importante reconocer el papel que cumplen los ejercicios espirituales en los asuntos prácticos de la vida humana actualmente como en la toma de decisiones, la paz interior, la resolución continua y progresiva de la inquietud de sí, el conocimiento de sí y, en definitiva, el sentido y significado de la existencia. Por tal motivo el objetivo que se propone este artículo es presentar una reflexión que desarrolle por un lado el sentido de los ejercicios espirituales grecolatinos del primer y segundo siglo, para que en un segundo movimiento se justifique la necesidad de éstos en la actualidad cuya orientación permite conducirse de manera auténtica en el mundo.
EL VALOR PEDAGÓGICO DE LA LEY : APROXIMACIONES PARA EL DESARROLLO PERFECTIVO DEL SER HUMANO DESDE LA PERSPECTIVA DE FRANCISCO RUIZ SÁNCHEZ
Authors:   Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET-UNCUYO, Eliana Juri Yamila , Di Marco María Elisa ,   Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET-UNCUYO
Published: June 2022

Se presenta en este trabajo la importancia de la ley como elemento pedagógico en la sociedad política. En este sentido, se reflexiona sobre su valor desde un enfoque realista en donde se demuestra una mirada de la ley más amplia que traspasa los límites del mero señalamiento de lo injusto. En efecto, a partir de la consideración de la escisión antropológica que han generado las teorías modernas del derecho, se profundiza –desde el planteo educativo que propone Francisco Ruiz Sánchez en el marco de una filosofía cristiana– sobre el valor perfectivo de la ley y su posibilidad educativa. Se concluye sobre la necesidad de una visión más amplia que contemple la integridad del ser humano y la finalidad perfectiva de la ley.
A Recent Review On 3D-Printing: Scope and Challenges with Special Focus on
Pharmaceutical Field
Authors: Singh Shubham , Kumar Mohit , Doolaanea Abd Almonem , Mandal Uttam Kumar
Published: June 2022

Background:

The presentation of 3D printing in drug innovation especially focuses on the advancement of patient-centered dosage forms based on structural design. Rising interest for customizations 3D printed inserts during surgeries combined with developing R&D speculations is driving the medical services.

Introduction:

3D printing technique is considered emerging digitized technology and it is beneficial for future progression and development of customized dosage forms, prostheses, implantable medical devices, tissue making, disease modeling, and many more. 3D Printing technology has numerous benefits such as minimum waste production, freedom of design, and the ability to make complex structures as well as rapid prototyping.

Method:

Various 3D printing techniques are utilized (such as drop on solid deposition, selective laser sintering/ melting, drop on drop deposition, stereolithography, fused deposition modeling, and pressure-assisted techniques) for the preparation of various pharmaceuticals, such as tablets, films, oral films, mouth guards, pellets, polyprintlets catheters, etc.

Results:

With the help of various 3D printing techniques, researchers minimize dose frequency and side effects of drugs with the formation of multilayer tablets or polypills and benefited the person, who is suffering from various diseases at a particular time. For example, multilayer polypills containing paracetamol, caffeine, naproxen, chloramphenicol, prednisolone, and aspirin. This study, most importantly, demonstrated the possibility of 3D printing for making diverse polypills to advance patient personalization with the help of the 3D printing technique.

Conclusion:

The authors hope that this article will give a valuable boost to energize future researcher working in the pharmaceutical field. Due to the novelty and particular highlights, 3D printing has the inborn ability to settle numerous formulation and medication conveyance challenges, which are often connected with poorly aqueous solubility. It has many unmet regulatory challenges that need to be addressed.
Luliconazole Topical Dermal Drug Delivery for Superficial Fungal Infections:
Penetration Hurdles and Role of Functional Nanomaterials
Authors: Babu Chanti Katta , Shubhra  , Ghouse Shaik Mahammad , Singh Pankaj Kumar , Khatri Dharmendra Kumar , Nanduri Srinivas , Singh Shashi Bala , Madan Jitender
Published: June 2022

Luliconazole is the first and only anti-fungal agent approved for the short-term treatment of superficial fungal infections. However, commercially available conventional topical dermal drug delivery cargo of luliconazole is associated with certain limitations like lower skin permeation and shorter skin retention of drug. Therefore, present review is an attempt to decode the penetration hurdles in luliconazole topical dermal drug delivery. Moreover, we also summarized the activity of functional nanomaterials based drug delivery systems employed by the scientific fraternity to improve luliconazole efficacy in superficial fungal infections on case-to-case basis. In addition, efforts have also been made to unbox the critically acclaimed mechanism of action of luliconazole against fungal cells. Under the framework of future prospects, we have analyzed the combination of luliconazole with isoquercetin using in-silico docking technique for offering synergistic antifungal activity. Isoquercetin exhibited a good affinity for superoxide dismutase (SOD), a fungal target owing to the formation of hydrogen bond with Glu132, Glu133, and Arg143, in addition to few hydrophobic interactions. On the other hand, luliconazole inhibited lanosterol-14α-demethylase and consequently blocked ergosterol. In addition, nanotechnology and artificial neural network (ANN) derived integrated drug delivery systems may also be explored for augmenting the luliconazole therapeutic efficacy in topical fungal infections. Synergy of ANN models along with topical nanoscaled drug delivery may help to achieve critical quality attributes (CQA) to gain commercial success.
The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction
Authors: Lee Shaun W. , Moran Thomas E. , Hammers Daniel E.
Published: June 2022

SARS-CoV2, Severe acute respiratory syndrome coronavirus 2, is a novel member of the human coronavirus family that has recently emerged worldwide to cause COVID-19 disease. COVID-19 disease has been declared a worldwide pandemic with over 270 million total cases, and >5 million deaths as of this writing. Although co-morbidities and preexisting conditions have played a significant role in the severity of COVID-19, the hallmark feature of severe disease associ-ated with SARS-CoV2 is respiratory failure. Recent findings have demonstrated a key role for en-dothelial dysfunction caused by SARS-CoV2 in these clinical outcomes, characterized by endothe-lial inflammation, the persistence of a pro-coagulative state, and major recruitment of leukocytes and other immune cells to localized areas of endothelial dysfunction. Though it is generally recog-nized that endothelial impairment is a major contributor to COVID-19 disease, studies to examine the initial cellular events involved in triggering endothelial dysfunction are needed. In this article, we review the general strategy of pathogens to exploit endothelial cells and the endothelium to cause disease. We discuss the role of the endothelium in COVID-19 disease and highlight very re-cent findings that identify key signaling and cellular events that are associated with the initiation of SARS-CoV2 infection. These studies may reveal specific molecular pathways that can serve as po-tential means of therapeutic development against COVID-19 disease.
Tannic Acid as a Green Cross-linker for Biomaterial Applications
Authors: Biazar Esmaeil , Moghaddam Seyed Yasaman Zolfaghari , Esmaeili Javad , Kheilnezhad Bahareh , Goleij Fatemeh , Heidari Samaneh
Published: June 2022

Plant-derived tannic acid as a green material can play an important role in improving the
mechanical and physical properties of biomaterials. Tannic acid can be used as an antioxidant, antimicrobial,
and cross-linking agent in biomaterial products due to its unique functional groups. Its active
phenolic groups can react with biomaterial functional groups to form bonds that improve performance.
In this review, the mechanism of effectiveness of tannic acid as a natural crosslinker in improving
the properties of biomaterials for various applications, such as tissue engineering, tissue adhesives,
drug delivery, wound healing, and toxicity studies, has been investigated. In general, tannic acid
can be a suitable alternative to synthetic crosslinkers in biomaterial applications.
Application of LFER to the N(1)-H Acidities of Five-Membered
Nitrogen Heterocyclic Ring Systems: A Review on Graduate
Chemical Education Exercise
Authors: Vandanapu Jagannadham , Rachuru Sanjeev
Published: June 2022

An attempt is made for the first time in our laboratory to apply the Hammett and
Taft equations to the five-membered heterocyclic ring systems pyrroles, pyrazoles, imidazole,
and triazoles. It is shown that the pKa values of N(1)-H acidities of 3-X-pyrroles, 3-Xpyrazole,
4-X-pyrazole, 4-X-imidazole, 3-X-1,2,4-triazole and 4-X-1,2,3-triazole correlated
well with Hammett σ values.
Family Relations of University Students in Times of Pandemic by
COVID-19: Feelings and Tensions
Authors: Suárez-Barros Astrid Sofía , del Pilar Morad-Haydar María , Castillo- Bolaños Jennifer , Rojas-Otálora Alfredo , García-Acuña Yomaira , Alarcón-Vásquez Yolima , Morales Castro Yolanda Rosa , García-Navarro Ángela , González-Gutiérrez Orlando , Escobar Sarelys Avendaño , González-Martelo Victoria , Támara-Arrázola Elcie , Diaz-Lobo Julieth
Published: June 2022

Objective:

The objective of this research was to reveal the feelings and tensions that
characterize the family relationships of university students in times of pandemic and confinement conditions due to COVID-19.

Methods:

The method was qualitative, and the feelings and tensions in the family and educational context of 584 university students were evaluated, from a qualitative proposal and a
hermeneutic approach, anchored to the question: How have the affective manifestations been,
in terms of feelings and tensions, in the family relationships of university students, academically active, in the Caribbean Region of Colombia, during the mandatory confinement process
derived from the COVID 19 pandemic?. The methodological design was structured from the
concepts of the Grounded Theory, applied to the data obtained through virtual techniques and
instruments, such as an online survey. The organization of the information to generate the results was made from descriptive, analytical and interpretive coding, supported by matrices and
theoretical maps.

Results and Discussion:

There are feelings and tensions in three directions: Negative Feelings
(in tension) such as anxiety, stress and depression; positive feelings, joy, adaptation and ambiguous feelings, which show ambivalence and variability, which are reflected in family relationships and three senses: They have improved, remain the same and have worsened, according to each type, dynamics and characteristics of the family, associated with gender, coping
mechanisms and socioeconomic level.

Conclusion:

Families were transformed due to the pandemic, and relationships and interactions
were found that exacerbated tensions or factors of protection and care among family members,
with emotional overload, with stress from work and study.
'Truth is Stranger than Fiction': Representations of Greece in the Wide World Magazine
Authors: Koilia Ismini
Published: June 2022

This paper examines visual representations of Greece as presented in two articles in the Wide World Magazine (1898-1965) in 1908. The Wide World Magazine was a British illustrated magazine with almost exclusive male authorship and a powerful slogan: ‘truth is greater than fiction’. By means of Multimodal Discourse Analysis, the paper focuses on both photographs and illustrations in order to analyse the British gaze towards Greece at the time. At the same time, through representations of Greeks as the Other, the British travellers engage in their own identity construction. The material demonstrates a shift from the travellers’ preoccupation with the country’s classical past to what they think of a more authentic Greece. It also reveals a change in the attitude of the travellers, who distinguish themselves from tourists and see themselves rather as ethnographers. Finally, considering the complex relations between Greece and the United Kingdom, these representations of Greece will be linked to British political interests.
Los aljibes de Sincelejo. Una mirada desde la sostenibilidad
Authors: Martínez Osorio Gilberto , Vergara Iglesia Judith , Mendivil Marianela , Monterroza Cuello Francisco
Published: June 2022

El presente artículo condensa los resultados de una indagación sobre la correspondencia entre los antiguos dispositivos de manejo del agua de la ciudad de Sincelejo, Sucre, Colombia, con los sistemas de manejo sostenible del agua en la actualidad. Se intenta demostrar con este trabajo que, en el conjunto urbano arquitectónico construido a lo largo de la primera mitad del siglo XX, que en la actualidad se reconoce como el centro histórico de Sincelejo, existieron prácticas que encajan en las perspectivas actuales de manejo sostenible y autosuficiente del agua; las cuales pueden ser retomadas como una alternativa, ante las dificultades del sistema de acueducto y sus poco halagüeñas proyecciones, producto de la sobreexplotación a la que esta expuesto el acuífero de Morroa, única fuente de suministro de agua en la región de las Sabanas del Departamento de Sucre. El trabajo se soportó en un análisis comparativo entre las características técnicas de los aljibes del pasado, los cuales fueron levantados y catalogados, versus los conceptos de manejo sostenible del agua, a los cuales se accedió a través de una revisión bibliográfica en bases de datos y bibliotecas.
UPZ 67 Lucero Ciudad Bolívar, desde la perspectiva del imaginario y el mejoramiento integral
Authors: Guerrero Torrenegra Alejandro
Published: June 2022

Las periferias espontáneas de Latinoamérica se han tratado de forma paternalista, tangencial, generalista, lo que limita la compresión del imaginario popular colectivo, dentro del escenario marcado por la globalización y la segregación socioespacial, que tienden a diluir y fragmentar el tejido urbano, produciendo las construcciones y reconstrucciones autogestionadas, sin planificación. Se parte de reconocer que las ciudades son un artefacto complejo. Se propone, como objetivo principal, interpretar los imaginarios colectivos populares, a partir del Programa de Mejoramiento Integral de Barrios (PMIB), entre los años 2013-2015, en la UPZ 67 Lucero, de la localidad de Ciudad Bolívar en Bogotá. La estrategia metodológica parte del análisis, desde la perspectiva fenomenológica hermenéutica, que permite identificar las múltiples causas-efectos. Finamente, se plantea que los PMIB no cuentan con los recursos para su funcionamiento. Tampoco concentra su funcionamiento en una única entidad.
A Smoking Cessation Mobile App for Persons Living With HIV: Preliminary Efficacy and Feasibility Study
Authors: Schnall Rebecca , Liu Jianfang , Alvarez Gabriella , Porras Tiffany , Ganzhorn Sarah , Boerner Samantha , Huang Ming-Chun , Trujillo Paul , Cioe Patricia
Published: June 2022

Background

The prevalence of smoking in the United States general population has gradually declined to the lowest rate ever recorded; however, this has not been true for persons with HIV.

Objective

We conducted a pilot test to assess the feasibility and efficacy of the Lumme Quit Smoking mobile app and smartwatch combination with sensing capabilities to improve smoking cessation in persons with HIV.

Methods

A total of 40 participants were enrolled in the study and randomly assigned 1:1 to the control arm, which received an 8-week supply of nicotine replacement therapy, a 30-minute smoking cessation counseling session, and weekly check-in calls with study staff, or to the intervention arm, which additionally received the Lumme Quit Smoking app and smartwatch.

Results

Of the 40 participants enrolled, 37 completed the follow-up study assessments and 16 used the app every day during the 56-day period. During the 6-month recruitment and enrollment period, 122 people were screened for eligibility, with 67.2% (82/122) deemed ineligible. Smoking criteria and incompatible tech were the major reasons for ineligibility. There was no difference in the proportion of 7-day point prevalence abstinence by study arm and no significant decrease in exhaled carbon monoxide for the intervention and control arms separately. However, the average exhaled carbon monoxide decreased over time when analyzing both arms together (P=.02).

Conclusions

Results suggest excellent feasibility and acceptability of using a smoking sensor app among this smoking population. The knowledge gained from this research will enable the scientific community, clinicians, and community stakeholders to improve tobacco cessation outcomes for persons with HIV.

Trial Registration

ClinicalTrials.gov NCT04808609; https://clinicaltrials.gov/ct2/show/NCT04808609