bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors of acceptance of e-commerce technology among society: integration of technology acceptance model
Authors: Oktaria Rini , Naibaho Sunny Angelia , Muda Iskandar , Kesuma Sambas Ade
Published: January 2024

This paper discusses the factors of Acceptance of E-commerce technology among society. It uses Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines to articles published in 2015-2023. This study involved an analysis of 150 papers from various database sources, and 26 papers were selected as data references for this study. As the results, there are three main quantitative and qualitative analysis which being observed as part of the Technology Acceptance Model (TAM) integration to examine the factors involved in the acceptance of e-commerce technology among society.
A Systemic Circular Model for innovative sustainable recycling of thermoplastics
Authors: Casoli Gianlauro
Published: January 2024

Sustainable recovery and recycling of plastics is becoming an increasingly important global issue. Waste from the plastics industry has seen an exponential increase, which is expected to continue in the future. Currently, the majority of the plastic waste generated is discarded and the gap between the amount of plastic waste discarded and incinerated compared to recycled is huge. Closing this gap requires addressing many systemic issues in the value chain through a more holistic, complex systems approach that better understands the different values, norms and behaviours intrinsic in patterns of relations between key stakeholders. Taking a complex systems perspective necessitates the advancement of new innovations and a more circular model for the recycling industry. It highlights specific innovations that provide disruptive ways to design and develop processes and products that go beyond traditional recycling technologies and systems to find new cost-competitive uses for plastic waste streams that are currently too expensive or not convenient to process. The work outlines a circular model for the plastics value chain to support these innovations. On the one hand, it focuses on increasing the level of global awareness and changing the mindset of society to move away from plastics and towards more innovative solutions. And on the other hand, it promotes legislation and financing that motivates companies in the plastics value chain to scale and grow these innovations. Such a circular model will not only ensure more sustainable production and consumption of plastics but provide a paradigm for addressing other global challenges.
Perspectives of Perioperative Chemotherapy in the Treatment of Resectable Pancreatic Cancer
Authors: Отченаш С.В. , Шмак А.И. , Ерзинкян Ф.В. , Мартынов Е.П. , Котов А.А. , Рынейская А.Д.
Published: January 2024

Рак поджелудочной железы (РПЖ) – системное заболевание, которое является серьезной проблемой в онкологии. Темпы роста заболеваемости РПЖ и неудовлетворительные результаты лечения позволяют прогнозировать, что в следующие десятилетия РПЖ станет второй ведущей причиной смерти среди онкологических заболеваний. В настоящее время единственный эффективный и потенциально излечивающий метод лечения резектабельного РПЖ – это хирургическое вмешательство. Протоковая аденокарцинома, составляющая 85–90% всех злокачественных новообразований поджелудочной железы, является агрессивной опухолью с высоким метастатическим потенциалом, чем обусловлен плохой прогноз для жизни у пациентов, которым выполнена радикальная операция и проведена адъювантная химиотерапия. Таким образом, оправданы разработка и внедрение таких методов лечения, как неоадъювантная и периоперационная химиотерапия. В статье представлен обзор литературных данных по лечению РПЖ, рассмотрены основные прогностические факторы опухоли, а также первые результаты разработанного метода комбинированного периоперационного лечения пациентов с резектабельным РПЖ.

Pancreatic cancer (PC) is a systemic disease that is a serious problem in oncology. The rate of increase in the incidence of PC and unsatisfactory results of treatment suggest that in the next decades, PC will become the second leading cause of death among cancers. Currently, the only effective and potentially curative treatment for resectable PC is surgery. Ductal adenocarcinoma, which accounts for 85–90% of all malignant neoplasms of the pancreas, is an aggressive tumor with a high metastatic potential, resulting in a poor prognosis for life in patients who underwent radical surgery and received adjuvant chemotherapy. Thus, the development and implementation of such methods of treatment as neoadjuvant and perioperative chemotherapy are justified. The article presents a review of literature data on the treatment of PC, the main prognostic factors of the tumor, as well as the first results of the developed method of combined perioperative treatment of patients with resectable PC.
Circulating Tumor DNA Liquid Biopsy in Patients with Non-Small Cell Lung Cancer
Authors: Короткевич П.Е. , Смирнов С.Ю. , Медведь А.В. , Пивоварчик С.Н. , Субоч Е.И. , Малькевич В.Т. , Портянко А.С.
Published: January 2024

Рак легкого занимает лидирующие позиции в структуре онкологической заболеваемости и смертности от злокачественных новообразований в мире. Историческим «стандартом» биологического материала для проведения молекулярно-генетического тестирования является опухолевая ткань. Альтернативным минимально инвазивным методом изучения молекулярных характеристик опухоли является жидкостная биопсия. Наиболее перспективным и изученным субстратом для анализа является циркулирующая опухолевая ДНК (цоДНК) плазмы крови. Данный подход характеризуется малой инвазивностью, простотой многократного получения биоматериала и достаточно высокой концентрацией цоДНК у пациентов с распространенными формами опухолей. В статье отражены методология анализа цоДНК, возможности использования цоДНК для диагностики молекулярно-генетических нарушений, мониторинга эффективности проводимого лечения и выявления механизмов резистентности у пациентов с метастатическим немелкоклеточным раком легкого, а также оценки минимальной остаточной болезни после радикального лечения.

Lung cancer is the leading cause of cancer and cancer-related mortality worldwide. Tissue biopsy is the gold-standard diagnostic method used to confirm the diagnosis of cancer and to identify actionable targets. Liquid biopsy is a minimally invasive alternative to tissue biopsy. The most promising and studied tumor-derived material is circulating tumor DNA (ctDNA) detectable in the blood. This approach is characterized by low invasiveness, ease of repeated examination and a sufficiently high concentration of cDNA in patients with advanced disease. The methodology of ctDNA analysis, the possibility of using ctDNA for the assessment of oncogenic driver alterations, treatment response monitoring and identifying resistance mechanisms in patients with metastatic non-small cell lung cancer, as well as assessing the minimal residual disease after radical treatment, are described in the article.
El discurso de opinión de los diarios La Nación y Clarín en la construcción del republicanismo de la Argentina actual
Authors: Velisone Julia Evangelina
Published: January 2024

La significación y el uso de conceptos como «republicanismo», en la actualidad, se encuentra presente en el campo académico, político y mediático. Dichos espacios presentan formas de intervención, enunciadores y géneros discursivos diferenciadas, pero que también se articulan en la producción de sentidos que interpretan la realidad y el accionar en la misma. Las modificaciones en dichos procesos y espacios, así como en sus relaciones, otorgan relevancia en el estudio del discurso de opinión en tanto híbrido que participa del debate político desde el espacio mediático. A partir de lo anterior, este trabajo indaga en el discurso de opinión de los diarios La Nación y Clarín durante el año 2019, siendo escenario de elecciones nacionales en la Argentina, delimitado por la participación en la significación del republicanismo. Dicho análisis posibilita dar cuenta de la especificidad del discurso de opinión, sus formas de legitimación y jerarquía, así como de su articulación con el discurso político del sector que utiliza hegemónicamente el republicanismo.
Comparative Assessment of Surgical Treatment Outcomes in Patients with Sacroiliac Joint Injury
Authors:   Semey Medical University, Semey, Republic of Kazakhstan, Kassymov Kuanysh T. , Zunussov Yersin T. ,   International Scientific Center of Traumatology and Orthopedics, Almaty, Republic of Kazakhstan., Tlemissov Aidos S. , Yestemessov Nurzhan T. ,   ”Shymkent City Multispecialty Hospital” of State Public Healthcare Institution, Abdumaulenov Askhat U. ,   ”Shymkent City Multispecialty Hospital” of State Public Healthcare Institution, Rakhanskaya Yevgeniya V. ,   Semey Medical University, Semey, Republic of Kazakhstan
Published: January 2024

stract The aim of the study is to evaluate the results of surgical treatment in patients with sacroiliac joint injury. Methods. An analysis of the results of surgical treatment of 60 patients with sacroiliac joint injury was conducted at the Center of polytrauma and orthopedic surgery of the State Public Healthcare Institution “Emergency Hospital” in Abai Region, the Trauma and Endoprosthetics Department of the State Public Healthcare Institution “Multispecialty City Hospital No. 1” in the city of Astana, and the “Shymkent City Clinical Hospital No. 1” from June 2019 to August 2022. Patients were divided into two groups. Patients in the control group underwent surgery using the standard technique, while patients in the experimental group underwent surgery using a device developed by us for minimally invasive locking osteosynthesis of sacroiliac joint injuries. The study was a randomized controlled trial by design. Results. The use of the device for minimally invasive locking osteosynthesis of sacroiliac joint injuries leads to a significant reduction in the length of hospitalization for all types of sacroiliac joint injuries regardless of the patient’s initial condition (p=0.001). Correlation analysis revealed a correlation between the observation group and patient pain assessment at 12 months (p=0.001). According to the Majeed Pelvic Score at 12 months, the maximum score in the experimental group was 98 points, while in the control group, it was 70 points. A satisfactory assessment on the Majeed Pelvic Score at 12 months was observed in 3 (10%) of patients in the control group and none in the experimental group. There were no unsatisfactory responses in both groups (significant differences were found, p=0.001). Conclusions. The use of the device developed by us for minimally invasive locking osteosynthesis of sacroiliac joint injuries reduces the length of hospitalization and the time to return to work (12 months in the control group and 8 months in the experimental group). The absence of pain in patients after 12 months in the experimental group was 26 (86.7%) and 20 (66.6%) in the control group. According to the Majeed Pelvic Score in the long term (3, 6, and 12 months), the frequency of excellent results increases from 13.3% to 90.0% in the experimental group and from 10% to 73.4% in the control group.
CATEGORY SHIFT ANALYSIS IN THE BILINGUAL INFORMATION BOARDS AT MUSEUM SANDI YOGYAKARTA
Authors: Misbahul Ahmad , Nurhantoro Tri Septa , Hapsari Apriliana
Published: January 2024

Bilingual information has an important role in bridging communication from one language to another, and this also happens in the tourism field. Currently, the Indonesian government is making tourism as one of the primary sectors in increasing state income. Since there is the importance of bilingual information, this research proposes to examine the quality of the translation of the bilingual information boards at Museum Sandi and describe the relationship between category shifts and the quality of the degree of equivalence meaning. The research employed a qualitative descriptive method in discussing the types of category shifts and the degree of quality equivalence meaning on the bilingual information board. This research classified types of category shift and meaning equivalence of translation found in the translated text into the columns and presented the data in the form of numbers and percentages. This research shows that the category shift occurring in bilingual information boards at Museum Sandi Yogyakarta is still relevant and understandable for foreign tourists.
Peran Soft Skill Terhadap Kinerja Karyawan Pada PT. RAPP Buatan Port, Siak
Authors: Aulia Nanda , Hamsal Hamsal
Published: January 2024

Penelitian ini bertujuan untuk mengeksplorasi dan menganalisis peran soft skill dalam konteks motivasi, kompetensi, dan komunikasi, serta bagaimana interaksi antara elemen-elemen ini memengaruhi kinerja karyawan di PT. RAPP. Dalam penelitian ini, digunakan metode kuantitatif dengan pendekatan deskriptif, dengan teknik pengumpulan sampel secara acak. Perangkat lunak smartPLS (Partial Least Square) versi 3.0 digunakan untuk mengolah data. Hasil penelitian ini menunjukkan bahwa motivasi memiliki pengaruh positif dan signifikan terhadap komunikasi, dan kompetensi juga berdampak positif dan signifikan terhadap komunikasi. Komunikasi sendiri memiliki pengaruh positif dan signifikan terhadap kinerja karyawan. Selain itu, motivasi juga secara positif dan signifikan memengaruhi kinerja karyawan melalui perantaraan komunikasi, dan kompetensi juga memiliki dampak positif dan signifikan terhadap kinerja karyawan melalui komunikasi. Penemuan ini memberikan pemahaman yang penting namun belum banyak diteliti dalam konteks organisasi yang berusaha meningkatkan produktivitas karyawan dengan mengintegrasikan faktor-faktor motivasi, kompetensi, dan komunikasi dalam pengembangan kemampuan soft skill mereka.
Pengaruh Servant Leadership Style dan Komunikasi Interpersonal terhadap Kepuasan Kerja dengan Motivasi Kerja sebagai Variabel Mediasi pada Tenaga Kependidikan di Universitas Kota Pekanbaru
Authors: Fauzi Lara , Deswarta Deswarta
Published: January 2024

Penelitian ini dilaksanakan dengan tujuan menilai dampak gaya kepemimpinan berlandaskan pelayanan (servant leadership style) dan komunikasi interpersonal terhadap tingkat kepuasan kerja pada staf akademik Universitas Kota Pekanbaru. Studi ini adalah penelitian berbasis metode kuantitatif yang menggunakan pendekatan deskriptif. Metode kuantitatif adalah pendekatan yang digunakan untuk mengkaji suatu populasi dan sampel yang telah ditentukan, serta melibatkan pengambilan sampel secara acak. Data dikumpulkan dengan menggunakan instrumen penelitian. Software Structural Equation Modeling yang berbasis Partial Least Squares (SEM-PLS) digunakan untuk menganalisis data dalam penelitian ini. Hasil penelitian menunjukkan bahwa gaya kepemimpinan berlandaskan pelayanan dan komunikasi interpersonal memiliki pengaruh signifikan terhadap kepuasan kerja, dengan motivasi kerja bertindak sebagai faktor mediasi dalam hubungan tersebut.gsung dan tidak langsung pada tenaga kependidikan di Universitas Kota Pekanbaru.
Bacteriological monitoring of poultry (chickens, turkeys) and compound feed for their diet in Ukraine
Authors: Muzyka N. M. , Maiboroda O. V. , Echkenko R. V. , Rula O. M.
Published: January 2024

The article presents the results of studies conducted during 2021 on the circulation of bacterial pathogens among poultry (chickens, turkeys) from industrial and private households in Ukraine, as well as the microbiological contamination of feed and components for their production. 138 isolates of bacterial cultures were isolated from chickens in poultry farms of various forms of ownership, and 12 cultures of microorganisms were isolated from turkeys of different ages in private households. The circulation of a wide range of microorganisms from the families Enterobacteriaceae, Staphylococcaceae, Enterococcaceae, Pseudomonadaceae, Clostridiaceae, Mycoplasmataceae was established in poultry, in particular, three isolates of the causative agent of toxic infections – Salmonella Enteritidis were isolated. 31.4% (16 samples out of 51 tested) of compound feed and their components did not comply with the quality and safety criteria. The main bacterial contaminants of the feed were conditionally pathogenic microorganisms of the Enterobacteriaceae, Bacillaceae, Pseudomonadaceae, Enterococcaceae and Staphylococcaceae families. In addition, a culture of Salmonella spp. was isolated from one feed sample. In the future our researches may be directed to the role of the natural reservoir of pathogens (especially poultry and wild birds) in the formation of antibiotic resistant forms of bacteria
Morphological and biochemical changes in the blood of piglets suffering from Eimeriosis and Balantidiosis
Authors: Bohach О. М. , Kovalenko L. V. , Paliy A. P. , Bogach М. V.
Published: January 2024

The purpose of the work was to study changes in the morphological and biochemical parameters of the blood of 50-day-old piglets spontaneously infested with Eimeria and Balantidia. An experimental group of animals spontaneously infested with Eimeria and Balantidia and a control group (n=5) not infested were formed. To examine feces for the presence of Eimeria, the McMaster method in Raynaud's modification, Balantidia - native smear was used. Changes in morphological and biochemical indicators of blood during the mixed course of eimeriosis and balantidiosis were determined. In the blood of piglets infected with Eimeria and Balantidia, a decrease in the hemoglobin content by 10.4% and the number of erythrocytes by 17.0% was established. At the same time, the number of leukocytes increased by 22%. In the leukogram, the percentage of eosinophils increased by 40.0%, rod- and segmented-nuclear neutrophils by 26.3% and 2.1%, respectively. The number of monocytes increased by 35.3%, which indicates the appearance of foci of inflammation in the animal's body. An increase in the leukocyte index of intoxication by 11.1% indicates the severity of the inflammatory process. In infected piglets, a decrease in total protein content by 6.5% due to a significant decrease in albumin content by 28.3% was recorded. An increase in the concentration of CIC by 23.5%, the activity of the enzymes AlAT and AsAT by 75.4% and 35.9%, respectively, confirms the development of the pathological process and the occurrence of accompanying structural and functional changes in the internal organs of piglets. During the mixed course of eimeriosis and balantidiosis in 50-day-old piglets, leukocytosis and eosinophilia, an increase in the number of rod-shaped and segmented neutrophils, lymphopenia and monocytosis are observed. Changes in indicators indicate an exacerbation of the inflammatory process in the body of infected piglets and a toxic effect in the places of parasitism - the small and large intestines. In the biochemical composition of the blood serum of piglets with the development of the disease, there is a decrease in the content of total protein and albumins, which is associated with a violation of the biloxintizing function of the liver, and an increase in β-globulins indicates a suppression of the immune response to invasion. An increase in the activity of AlAT and AsAT enzymes indicates the development of dystrophic processes in the liver, which plays a primary role in the neutralization of toxins produced in the body of animals. An increase in the concentration of CIC indicates the gradual development of the immune response to the course of the disease
Distribution of ecto- and endoparasites in cats of Kharkiv Region
Authors: Kiptenko A. V. , Dunaev Yu. K. , Bogach М. V. , Bogach D. M.
Published: January 2024

The purpose of the work was to determine the distribution of various ecto- and endoparasites of the gastrointestinal tract that infect cats of the urban and rural populations of the Kharkiv region for the first time. Studies on ecto- and endoparasites were conducted in 177 cats of the urban population, of which 112 were domestic cats and 65 homeless animals and 98 cats of the rural population of the Kharkiv region in the period from March to July 2023. Data were collected on the location, age and sex of the animals and additionally (in the case of private animals) on anti-parasitic treatment. In 275 examined cats, 5 different ecto- and endoparasites were detected with prevalence ranging from 7.1% to 32.3%. Ctenocephalides felis was registered in 7.1% of domestic cats, 29.2% of homeless cats of the urban populations and 18.4% of cats of the rural populations. Infestation with Otodectes cynotis ear mites was highest in stray cats (32.3%), while cats from the rural populations had a lower infestation rate of 9.9% and pets from the urban populations — 14.4%. In homeless cats of the urban populations, eggs of helminths Toxascaris leonina (29.2%) and Uncinaria stenocephala (18.5%) were recorded the most. The prevalence of Toxascaris leonina in domestic cats of urban and rural populations was almost at the same level — 18.8% and 19.4%, respectively. Taenia taeniaeformis was recorded in stray cats from urban (3.1%) and rural (6.1%) populations. Taenia eggs were not detected in domestic cats of the urban populations. The total infestation endo- and ectoparasites of domestic cats in the urban populations was 52.7%, in the rural populations — 77.6%, while the infestation of homeless cats was 100%
FRANSUZ MILLIY KUTUBXONASIDAGI NAVOIY KULLIYOTIDAN BIR G‘AZAL
Authors: MALIKOV Akrom
Published: January 2024

Ushbu maqolada Alisher Navoiyning Parij shahridagi Fransuz Milliy kutubxonasida Turc 316 va Turc 317 inventar raqami bilan saqlanayotgan ikki jilddan iborat kulliyotdan o‘rin olgan “G‘aroyib us-sig‘ar” devonida 26-tartibda kelgan 9b–10a-betlaridagi g‘azal kontekstual metod asosida tahlil qilingan. Bu g‘azal Alisher Navoiy mukammal asarlari to‘plami 20-jildida rasmiy devonlarga kiritilmagan g‘azallar qatorida keltirilgan. Maqolaning yangiligi shundaki, mazkur matn hali navoiyshunoslar tomonidan tahlil yoki sharhga tortilgani kuzatilmagan, qolaversa, unda g‘azal kontekstual tahlil metodologiyasi asosida o‘rganilgan. G‘azalga Alisher Navoiy ijodi kontekstining bir qismi, Alisher Navoiy ijodiy konseptini namoyon etuvchi bir qirra sifatida qaralgan va unda tarannum etilgan majoziy muhabbat tasavvuf ma’rifatining o‘zak g‘oyalaridan ekanligiga urg‘u berilgan. Matn bevosita Alisher Navoiy kulliyotining faksimil elektron nusxasidan foydalanilgan holda tadqiqqa tortilgan, Alisher Navoiy istifoda etgan eski turkiy alifbo va imloda taqdim qilingan.
HIGH-GRADE SEROUS CARCINOMA ARISING FROM ENDOMETRIAL POLYP - A RARE CASE REPORT.
Authors: G Harshini , M Shanthi , K Jayashree
Published: January 2024

Polyp-related endometrial serous carcinoma is a rare variant of endometrial cancer that arises typically in
postmenopausal women associated with the rapid progression of the disease. Serous carcinoma is a highly aggressive
tumor characterized by a complex papillary growth pattern with high cytological atypia and extensive necrosis. As a result, most serous
endometrial carcinomas are found to have metastasized at the time of diagnosis. Serous tumors are poorly differentiated. The modality of
treatment varies according to tumor type, and prognosis depends mainly on the stage at the time of diagnosis for endometrial carcinomas. Women
with serous carcinoma may be treated with chemotherapy even in the absence of extrauterine metastasis, unlike endometrioid carcinoma.
Mutation of the TP53 tumor suppressor gene occurs as an early event in the pathogenesis of serous endometrial carcinoma. Postmenopausal
women at risk should be evaluated judiciously by endometrial biopsies for early diagnosis and management; since it accounts for up to 40% of
endometrial cancer-related deaths.
EFFECT OF DONOR PREDONATION VARIABLES ON THE QUALITY OF SINGLE DONOR PLATELETS
Authors: Bhushan Reema , Arya Anita , Pancholi Neeraj , Baghel Rakesh
Published: January 2024

Introduction: Plateletpheresis is as important aspect in the blood banking. Its quality is determined by the platelet yield
(that is platelet count of the single donor platelet/SDP product). In the prese Materials and Methods: nt study, complete
blood count (CBC) parameters of donors were studied and inuence of these parameters on the yield of the SDP was analysed. The most Results:
consistent parameter found to inuence the platelet yield was platelet count of the donor. Healthy donors with high platelet counts can yield better
platelet yield in SDPs in a shorter time and therefore improve the clinical outcome in patients. Haematological characteristics of the Conclusion:
donors needed to be studied to ensure a good quality of the plateletpheresis.
SERUM FERRITIN AS PREDICTOR OF OUTCOME IN OBSTRUCTIVE JAUNDICE.
Authors: H Ashika , Deori P , Das P K , Bhuyan K
Published: January 2024

The serum ferritin is a marker for total iron store in the body. It is also an acute phase reactant in liver disease, infection,
inammation and malignancy. Early analysis of Serum Ferritin in patients with jaundice can predict the outcome. The aim
of this study was to assess the utility of serum ferritin as predictor of outcome in patients with obstructive jaundice. This Materials And Methods:
study included 60 patients with obstructive jaundice treated in a teaching hospital. Majority (37) had malignant aetiology and 23 patients had
benign aetiology of obstructive jaundice. Data on Sr Ferritin, LFT and other haematological parameters were collected on the day of admission
and patients were followed up & compared with the outcome. Statistical analysis was done using R statistical language, Double side t-test and
Pearson's correlation test to study its signicance. The male female Results: ratio was 34:26 with age group of 30 - 75 years. Sr Ferritin on
admission was found to be signicantly different in patients who survived (mean=409) and those with poor outcome (mean=729.8, p-value =
0.0076, CI-546 +- 94.013). Values of ferritin was also signicantly different among those patients who required ICU admission and those who
didn't (p value <0.0005). Early analysis of Serum Ferritin levels in patients wit Conclusion: h obstructive jaundice might effectively predict the
disease severity and the need for early & appropriate management to improve the outcome.
COMPARISION OF ACUTE TOXICITIES AND RESPONSE OF STANDARD CHEMORADIATION VERSUS HYPERFRACTIONATED RADIOTHERAPY IN HEAD AND NECK CANCERS
Authors: Padmavathi Buduru
Published: January 2024

Introduction: Comparison of Acute Toxicities and Response of Standard chemoradiation Versus
Hyperfractionationated Radiotherapy in Head and Neck Cancers Head and Neck Cancers are the most Background:-
common malignancy among males in India. Carcinoma of buccal mucosa is the most common cancer among Head and Neck Cancer due to high
rate of tobacco chewing habit. Head and Neck Cancer are Aggressive tumors. Tumor response is 52-86%. Loco regional control is 22-46%
conventional fractionation. Locoregional recurrence is the most common form of recurrence in the head and neck cancers. To achieve good
Locoregional control in head and neck cancers, altered fractionations like hyperfractionation, accelerated fraction etc, concurrent
chemoradiation were come into clinical practice. To study the comparison of a Aims and objectives of study:- cute toxicities and response of
standard chemo radiation versus hyperfractionated radiotherapy in head and neck cancers T Methods:- he patients were selected according to the
inclusion and exclusion criteria total of 40 patients of head and neck squamous cell cancer were enrolled in this study and analyzed. All patients
uneducated baseline evaluation as per protocol. 40 patients of stage III-IV4B cancers to compare the acute toxicity and tumor response between
standard chemo radiation (CRT arm contained 25 patients) and Hyper fractionated Radio therapy (HFR arm contained 15 patients). Result:-
Acute Toxicity: Grade 2 toxicity of skin mucous membrane, nausea , vomiting , salivary gland pharynx and hematology is more in CRT arm.
Grade 3 toxicities of nausea and vomiting was more in CRT arm where as grade 3 toxicity of skin, mucous membrane and pharynx was more in
HFRT arm. All there toxicities were statistically signicant. Overall treatment time was 49.09 days in CRT arm and 54.75 days in HFRT arm.
Standard chemo radiation is better that HFRT in Head and Neck (Oral Cavities) Cancers because of less toxicity Less mean overall treatment
time, less number of treatment breaks and better response. The overall loco regional response rate at the end of treatment was 59.1% on CRT are
and 41.6% in HFRT arm. The difference was not statistically signicant (P= 0.54) The Loco regional failure at the end of treatment was 40.9% in
CRT arm and 58.4% in HFRT arm. This difference was not statistically signicant ( P=0.43) Chemo radiation is better than HFRT Conclusion:-
on Head and Neck (Oral Cavity) Cancers because of less toxicity , less means overall treatment time, less number of treatment breaks and better
response.
PARENTAL ACCEPTANCE OF COVID-19 VACCINE AND DETERMINANTS OF VACCINE HESITANCY.
Authors: Ponnuraj Nirosha , Padmanabhan Kamalanathan , Muthuarumugam Saravanan
Published: January 2024

Background: Our study aimed to assess the parental acceptance of COVID-19 vaccination for their children and evaluate
the factors inuencing their decision toward vaccination. A cross-sectional s Materials And Methods: urvey in Tamil
Nadu gathered data from parents of children aged 6 months to 18 years. It assessed their willingness to vaccinate both their children and
themselves against COVID-19 and examined their opinions on the vaccine. The study used multistage random sampling and employed Chisquare tests to analyze factors inuencing vaccination acceptance. Among t Results: he 653 participants, 493 parents (75.5%) intended to
vaccinate their children against COVID-19. Parents of children aged 12 to 18 years(p-0.0005), parents aged 35 to 44 years (p-0.001), parents who
have not refused any vaccine in the past (p-0.0005), parents who were aware of Covid19 vaccination drive for children (p-0.001), parents who
have received the vaccine for themselves (p-0.0005) were signicantly more likely to accept the Covid19 vaccine for their children. Parents who
considered the vaccine safe and effective (p-0.0005) had better acceptance. The Availability of free vaccines was identied as the major barrier
toward vaccination (39%). Raising public awareness, enhancing routine childhood vaccination, and pr Conclusion: oviding free vaccines can
improve vaccination program effectiveness.
A STUDY OF NEUROPATHY IN TYPE 2 DIABETICS WITH OR WITHOUT ANEMIA: A CROSS SECTIONAL STUDY
Authors: Abbas Waseem Shah Mohammad , Amir Mohammad
Published: January 2024

Introduction: Anemia is a common condition in developing countries and females are at higher risk. Anemia is a risk for
neuropathy in diabetics. However, it largely remains untreated and unrecognized in diabetics. Thus the present study was
conducted to analyse nerve conduction (motor and sensory) in type 2 diabetics with or without anemia. Cross sectional Material and methods:
study included 100 diabetics (pre – menopausal females) between 30-45 years of age. They were further divided into with or without Diabetic
Peripheral Neuropathy (DPN) on the basis of Michigan Neuropathy Screening Instrument (MNSI). The motor and sensory nerve conduction
tests were carried in anemic and non-anemic group on the basis of the report of the blood sample analysed by the Automated Analyzer. Statistical
Analysis: the data was analysed using the statistical unpaired t test. The association between the DPN and anemia was done using the chi square
test. P value of less than 0.05 was taken as signicant. DPN was found in Results: 55 subjects and 45 were grouped as non DPN. 38 patients with
DPN were found to be anemic. The HBA1C%, mean duration of diabetes, mean age and fasting blood glucose were higher in DPN group whereas
the RBC and Hemoglobin levels were statistically lower in diabetics with peripheral neuropathy. The motor and sensory nerve conduction
velocities were found to be statistically decreased in anemic patients as compared to those without anemia. motor and sensory nerve Conclusion:
conduction velocities are reduced in type 2 diabetics with anemia and thus diabetics need to be screened for anemia and neuropathy. Early
detection of anemia will reduce the risk of complications.
PROGNOSTIC BENEFITS OF GENOMIC TESTING IN HEAD AND NECK CANCERS
Authors: Rajadurai. V Deepak , Joy Lyra , K Neha , Kumar. G Chethan , Babu Dayana , B. K Noorjihan.
Published: January 2024

Aim: To evaluate the cancer related mortality and morbidity based of the elucidation of the genomic basis of head and neck cancers and to see the
prognosis in customizing the treatment based of the genomic study. This is a Materials and Methods: prospective study were the patients of head
and neck cancers, presenting to the Head and Neck clinic of Sree Mookambika cancer centre, in kanyakumari, Tamil Nadu, from August, 2021 to
February, 2023, were chosen for this study. The age distribution of the patients ranged Results: from 18 to 74 years, with a median age of 45.94
years. There were 15 males and 3 females in the group. Family history was obtained patients of whom 6 had a family history of other cancers. There
were 11 patients with a history of exposure to tobacco, 3 with alcohol consumption history while the others did not report any risk factors. The study
identied somatic mutations in 9 out of 18 cases using a 48-gene panel of targetable mutations and 2 germline mutations. The genomic study
revealed germline mutations in BRCA – 5.5% in a patient with carcinoma nasopharynx and AIP- 5.5 %, somatic mutations in P53 in 3 patients16.6% and HRAS in 3 patients -16.6, while the other mutations detected were STK11 in a patient with mucoepidermoid carcinoma of the hard
palate, GNA11 -5.5% in metastatic alveolar sarcoma of the tongue, phosphatase and tensin homolog PTEN, and RB1 in a case of SCC involving the
gingivobuccal sulcus and the base of the tongue. Early genomic testing in head and ne Conclusion: ck cancers cases helps in customizing a
modifying the treatment protocol which in turn demonstrate potential prognostic benets compared to treatment protocol without genomic testing.
Assessment of registered and hidden epidemic process of tick-borne encephalitis in the Republic of Karelia
Authors: Rubis Lyudmila V. , Chevskaya Victoriya E. , Ekimova Olga V. , Safonova Olga S.
Published: January 2024

Introduction. The incidence of tick-borne encephalitis in the Russia remains relevant. The assessment of the epidemic process in the Republic of Karelia is important not only in terms of understanding its general patterns, but in connection with the growth of tourist attendance in the region.
Aims: To assess the current epidemic situation of tick-borne encephalitis in the Republic of Karelia, and to compare the characteristics of registered and hidden epidemic processes.
Materials and methods. The risk of infection and incidence were estimated based on the analysis of the registered cases of seeking medical help in connection with tick bites, the results of a study of tick-borne encephalitis virus (TBEV) infection rate in ticks, and the epidemiological investigation of cases of tick-borne encephalitis in 1992–2022. Clinical, gender and age structure, territorial distribution of patients and victims of the tick bites were compared with the results of serological studies of 2379 blood samples of the adult population, conducted in 2011–2022.
Results. Infection rates of ticks removed from humans ranged from 23.6–27.0% in 2002–2005 to 1.0% in 2022. In 2004, the TBEV antigen was detected in mosquitoes. The territory of risk is the southern part of Republic. However, the increase in number of cases of seeking medical help was observed in the northern part of Republic. The incidence rates exceeded the national average, especially in 2003–2004 (15.3–11.6 per 100 thousand). In 2021–2022, it decreased to 1.8–1.5 per 100,000. The dynamics of incidence had a high-degree correlation with the dynamics of seeking medical help and infection rates in ticks (R = 0.92 and 0.73). The reported incidence was lower than the estimated risk of infection. The meningeal forms of infection were most often diagnosed. The risk of the disease was higher in the elderly and in men, which was determined by the conditions of infection. Antibodies to TBEV were detected in 11.8 ± 0.7% of the examined persons.
Conclusion. A steady decrease in rates of registered tick-borne encephalitis incidence has been revealed in the Republic of Karelia, mainly due to the action of biological and natural factors. The assessment of seroprevalence made it possible to reveal the hidden part of the epidemic process.
An Investigation into Psychological Influence Techniques Using Language and Visuals in Milk Advertising in English and Vietnamese
Authors: Ha Thai Thi Xuan
Published: January 2024

This study delves into the realm of advertising psychology, specifically focusing on the employment of psychological influence techniques in milk advertisements in both English and Vietnamese. In the contemporary advertising landscape, where consumers are constantly bombarded with messages, understanding the nuances of psychological tactics becomes imperative for marketers. The research explores various elements integral to advertising effectiveness, including language, imagery, color, headlines, design style, brand logos, messages, and calls to action. Emphasizing the pivotal role of imagery, the study investigates how visuals create initial impressions and captivate viewer attention. Additionally, it scrutinizes the impact of advertising language, a specialized form of communication designed to elicit specific reactions and behaviors from the target audience. Drawing on a theoretical foundation rooted in Halliday's social semiotics, the research builds upon Leeuwen's advancements in semiotic theory, proposing 33 techniques that leverage language and imagery to influence consumer psychology. To provide empirical insights, the study utilizes a system of techniques put forth by the authors: Andrews, Van Leeuwen, Van Baaren (2013). Through the analysis of English and Vietnamese milk advertisements, this investigation aims to elucidate the nuanced effects of language and imagery in shaping consumer perceptions and behaviors within the context of milk advertising.
Determination of Fatty Acids and Minerals from Balanites aegyptiaca Fruit Kernel in Heglig Forest West Sudan
Authors: Ahmed Abdalwahab , Abdalgadir Hana , Mustafa Yasir A. A.
Published: January 2024

Balanites aegyptiaca, particularly its fruit, is often used as food and in traditional medicine and herbalists throughout Africa and Asia for the treatment of many ailments. The fruit kernel has a high concentration of oil and minerals. This study aims to examine fatty acids in the oil and minerals in the fruit kernel. The Samples are collected from the Heglig forest in west Sudan for the first time, and prepared for analysis using solvent extraction and acid digestion methods. The fatty acids content is identified using a gas chromatography-mass spectrometer (GC-MS) as well and minerals are detected by adopting inductively coupled plasma optical emission spectrometry (ICP-OES). The oil contained 41.66% unsaturated fatty acids 58.33% saturated fatty acids and a variety of minerals, the highest amount belonged to Sulfur (6.9 ppm), phosphorous (2.2 ppm), and iodine (2 ppm). GC-MS analysis observed 12 different proportions of fatty acid, Linoleic acid, Stearic acid, and Oleic acid have a peak.
A Framework to Enhance Information Security Governance in SMEs
Authors: Mwanje Derrick , Samuel Ocen , Tumwebaze Godfrey , Bukenya Moses
Published: January 2024

In the modern organizational landscape, information technology plays a pivotal role in shaping business processes. The increasing reliance on IT necessitates a focus on the confidentiality, availability, and integrity of both enterprise and customer data, making information security a paramount concern. This study delves into the challenges faced by Small and Medium-sized Enterprises (SMEs) in Fort Portal Central Division during their information security governance efforts, highlighting issues such as limited resources, budget constraints, time limitations, and a lack of expertise in drafting and ensuring compliance with security policies. To address these challenges, a comprehensive framework for improving Information Security Governance in SMEs was developed and evaluated. Primary data were collected from 351 respondents, including Proprietors, Directors, CEOs, Managers, and operations personnel, shedding light on the specific hurdles faced by SMEs. The proposed framework underwent rigorous evaluation based on design science parameters, demonstrating efficiency and usability. The results of the evaluation revealed that the developed framework effectively addressed the identified challenges, fulfilling the study's objective. The study recommends SMEs in Fort Portal City to implement the framework to enhance their Information Security Governance efforts. Additionally, policy makers in Uganda, including the National Information Technology Authority Uganda (NITA-U) and Uganda Investments Authority (UIA), can leverage the designed framework to make informed decisions regarding SMEs and information security management and governance. This research contributes valuable insights to the broader discourse on information security governance in SMEs, particularly within the context of Fort Portal City.
The Impact of E-Cigarettes on Oral and Dental Health: Narrative Review
Authors: Saad Mubarak Saeed , Hamad Abdulhakeem Saeed , Alasmari Mohammed Ali N , Alamri Arif Ali , Alamri Hesham Mohammed Saad , Alhamoud Saeed Mohammed , Alqahtani Abdulhadi Mohammed Fahad
Published: January 2024

E-cigarettes, also known as electronic cigarettes or vape pens, have become increasingly popular in recent years as an alternative to traditional tobacco products. However, there is growing concern about the potential impact of e-cigarettes on oral and dental health. This narrative review aims to provide an overview of the current evidence on the topic and to highlight the potential risks associated with e-cigarette use. One of the main concerns surrounding e-cigarettes is the potential for oral and dental health problems. E-cigarettes contain a liquid solution that is heated and inhaled as a vapor, and this vapor can contain a variety of chemicals and toxins. Some of these chemicals have been found to have adverse effects on oral health, including inflammation of the gums, dry mouth, and an increased risk of cavities. Additionally, the act of vaping itself can lead to oral health issues, as the repetitive motion of inhaling and exhaling can cause irritation to the mouth and throat. Furthermore, the nicotine content in e-cigarettes can also have negative effects on oral and dental health. Nicotine is a vasoconstrictor, meaning it restricts blood flow, which can lead to a decrease in the delivery of oxygen and nutrients to the gums and other oral tissues. This can result in a higher risk of gum disease and delayed healing after oral surgery or dental procedures. In addition, nicotine has been shown to contribute to the development of oral cancer, as well as other oral health issues such as tooth decay and tooth loss. More research is needed to fully understand the long-term effects of e-cigarettes on oral and dental health, but in the meantime, it is crucial for individuals to take steps to protect their oral health and to be aware of the potential risks associated with e-cigarette use.
Analysis Analysis of The Effect of Hot-Fit Models on Implementation of A Hospital Information System at Palangkaraya City Hospital
Authors: Astuti Sri , Adikara Fransiskus , Pamungkas Rian Adi
Published: January 2024

This research is based on several problems faced by health workers in 2022 before SIRS is implemented and there are plans to implement SIRS in 2023. The aim of this research is to reveal empirically the influence of perceived benefits, quality of information, organizational support and work engagement on the implementation of SIRS. This research is included in quantitative research with a cross-sectional study design, the population used is 30 health workers, the sampling technique uses a saturated sample which makes the entire population as respondents. The analysis method uses the three box method and PLS-SEM with the help of the Smart-PLS program. The results of the analysis conclude that perceived benefits, quality of information and organizational support have a positive and significant effect both simultaneously and partially on the hospital information system, while work engagement has a negative effect on the implementation of the hospital information system.
Perlindungan Hukum Terhadap Konsumen dari Produk Kosmetik yang Ilegal
Authors: Syafiqoh Firyal Arribah , Sudiro Amad
Published: January 2024

Perkembangan teknologi membawa perubahan pada dunia perdagangan, saat ini E-Commerce tumbuh dengan begitu pesat. pertumbuhan tersebut membawa dampak pada menjamurnya industri kosmetik di online shop, namun hal tersebut menyebabkan maraknya kosmetik illegal yang beredaran dipasar salah satunya merek Zayora. Tujuan dari penelitian ini adalah untuk memberikan kontribusi terhadap kesadaran konsumen mengenai penerapan perlindungan konsumen terhadap produk kosmetik ilegal dan memberikan rekomendasi perbaikan sistem.Metode penelitian yang digunakan dalam analisis kasus adalah penelitian hukum normatif yang sistematis. Dalam penelitian ini peneliti menggunakan data sekunder, dimana alat hukum primer yang digunakan adalah peraturan perundang-undangan. Teknik pengumpulan data yang digunakan dalam penelitian ini disebut penelitian kepustakaan (LR). Teknik analisis data yang akan digunakan dalam penelitian ini adalah hukum normatif, dimana analisis tersebut berkaitan dengan komponen-komponen substansi hukum yaitu teori, konsep, dan beberapa undang-undang yang berlaku Perlindungan hukum konsumen terhadap kosmetik illegal pada studi kasus Putusan No Nomor 687/Pid.Sus/2021/PN Ckr bahwa pelaku memperoleh sanksi pidana selama kurang lebih dua tahun dengan denda sebesar 10.000.000, hal ini menunjukkan bahwa terdapat upaya dalam melindungan konsumen. Penarikan serta penghentian produk yang beredar secara illegal tanpa adanya surat izin dari BPOM menunjukkan implementasi perlindungan hukum kepada konsumen, hal ini disebabkan karena sulitnya BPOM mengawasi perederan kosmetik yang dijual secara online untuk itu masyarakat dihimbau lebih teliti dalam membeli produk secara online.Berdasarkan temuan diatas dapat ditarik kesimpulan bahwa peran BPOM dalam pengawasan kosmetik illegal masih kurang, hal ini dapat dilihat dari ribuan kosmetik illegal tanpa izin yang beredar secara online.
Centralised Chaining for Wireless Personal Area Network
Authors: Halesh M R  , Chethan G Kottari  , Ahamed Jamaluddin , P Kedareshwar Rao  , Vinayak Y Sandimani
Published: January 2024

Centralised chaining represents a method of organizing and coordinating the communication and interaction among the nodes within the PAN. It aligns with the objective of developing a PAN protocol with high interference immunity and low radio noise. The proposed idea aims to optimize the interconnectivity of the PAN nodes, enabling seamless communication, sensing, actuation, and data transmission within the network. The need for high-quality data, that uses minimal power (1mW to 100mW) and long distances is increasing every day. Since ninety percent of devices are used internally, more bandwidth, low latency, high spectral efficiency, and high smooth output are needed. Additionally, as the user base expands, researchers face greater difficulty in creating a dependable and quick wireless communication system using these current gadgets. The proposed new design of the PAN is expected to overcome these issues with the help of advanced algorithms and protocols that improve the interconnectivity of the devices participating in the PAN.