bluuebunny/crossref_metadata_2025 huggingface dataset:
Ordered Changes in Methane Production Performance and Metabolic Pathway Transition of Methanogenic Archaea under Gradually Increasing Sodium Propionate Stress Intensity
Authors: Liu Mengxi , Li Yuanyuan , Zheng Zehui , Li Lin , Hao Jianjun , Liu Shuang , Wang Yaya , Qi Chuanren
Published: April 2024

This study examined the impact of sodium propionate concentration (0–40 g/L) on the methanogenic archaea in an inoculum which was cultured in basal nutrient medium, exploring its mechanisms and nonlinear stress intensity. The results indicated that at low concentrations, propionate-maintained homeostasis of the anaerobic digestion (AD) system and enriched Methanosaeta. However, when the concentration exceeded 16 g/L, the stability of the AD system was disrupted. The methanogenic pathway shifted towards a predominantly hydrogenotrophic pathway, resulting in a significant increase in methane yield. Below concentrations of 28 g/L, the AD system gradually enhanced its ability to utilize propionate in an orderly manner. At concentrations of 24–28 g/L, genera (e.g., Advenella and Methanosarcina) were enriched to adapt to the high-VFA environment. This was accompanied by a significant upregulation of genes related to the methylotrophic and hydrogenotrophic pathways, effectively mitigating propionate inhibition and enhancing methanogenesis. Conversely, excess concentrations (>30 g/L) suppressed methanogenesis-related genes and led to methane production arrest despite activating specialized propionate-metabolizing bacteria such as genus Pelotomaculum schinkii. As such, an increase in the stress intensity of propionate promotes a change in the metabolic pathways of methanogens and increases methane production; however, excessive sodium propionate was not conducive to maintaining the steady state of the system.
Metaverse Meets Smart Cities—Applications, Benefits, and Challenges
Authors: Maier Florian , Weinberger Markus
Published: April 2024

The metaverse aims to merge the virtual and real worlds. The target is to generate a virtual community where social components play a crucial role and combine different areas such as entertainment, work, shopping, and services. This idea is explicitly appealing in the context of smart cities. The metaverse offers digitalization approaches and can strengthen citizens’ social community. While the existing literature covers the exemplary potential of smart city metaverse applications, this study aims to provide a comprehensive overview of the potential and already implemented metaverse applications in the context of cities and municipalities. In addition, challenges related to these applications are identified. The study combines literature reviews and expert interviews to ensure a broad overview. Forty-eight smart city metaverse applications from eleven areas were identified, and actual projects from eleven cities demonstrate the current state of development. Still, further research should evaluate the benefits of the various applications and find strategies to overcome the identified challenges.
Performance of Flax/Epoxy Composites Made from Fabrics of Different Structures
Authors: Alipour Abdolmajid , Jayaraman Krishnan
Published: April 2024

Flax fibers have been shown to have comparable mechanical properties to some conventional synthetic fibers. Flax fabrics with different textile structures show differences in resistance against mechanical loads mainly rooted in fabric orientation and the resultant resin impregnation. Thus, in this study, flax fabrics with three different textile structures, fine twill weave, coarse twill weave and unidirectional, were used as reinforcements in an epoxy matrix. The surfaces of the fabrics were chemically treated using an alkaline treatment, and the alterations in fabric crystallinity index (CrI) were determined using X-ray diffraction (XRD). Experimental results confirmed that textile structures and CrI had significant effects on the mechanical properties of composites. Although an increment in CrI, resulting from chemical treatment, always enhanced tensile and flexural properties, it adversely affected damage development once composites were exposed to impact load. In terms of textile structures, unidirectional fabric outperformed woven fabrics in tensile and flexural properties while in impact properties, the latter had a better performance inducing less damage development. Finally, the mechanism of damage development in different composites was discussed in detail using Scanning Electron Microscopy (SEM) images. It is envisaged that the results of this study will provide an insight that will lead to the proper choice of the optimal kind of flax fabric for different applications.
A Review on False-Twist Texturing
Authors: Ortega Mathias , Saynisch Alexander , Yurtseven Bahar-Merve , Gries Thomas
Published: April 2024

The annual demand for fibres continues to rise worldwide. Consequently, more and more fibres must be produced to meet this demand, most of which are melt-spun polymeric man-made fibres. Smooth filaments made of polymers are mainly used for technical applications in industry. For use in clothing or home textiles, for example, a texturing process is used to give the filaments a crimp and thus a feel like that of natural fibres. In this state, they can be processed together with natural fibres and used in textiles. Partially oriented yarns (POY) are of great importance in texturing. The yarns are mainly crimped with the help of the so-called false-twist texturing process (FTTP). Since POY accounts for about 60% of the melt-spun filament yarn produced worldwide, the FTTP is the most important texturing process in the textile industry. In this paper, the main components of false-twist texturing (FTT) machines are explained, along with the state of the art and research for each component and its influence on the process. Relevant patents are discussed, as well as process optimisation techniques, innovative polymers, and yarn types recently used in FTT, followed by a conclusion and an outlook for the process.
Defining Disadvantaged Places: Social Burdens of Wildfire Exposure in the Eastern United States, 2000–2020
Authors: Morgan Grayson R. , Kemp Erin M. , Habets Margot , Daniels-Baessler Kyser , Waddington Gwyneth , Adamo Susana , Hultquist Carolynne , Cutter Susan L.
Published: April 2024

This study explores the relationship between wildfire exposure, social vulnerability, and community resilience across the 26 states east of the Mississippi River. This work centers around one research question: are there spatial differences in wildfire exposure that disproportionately impact disadvantaged communities in the Eastern United States over the recent period (2000–2020)? Employing remotely sensed wildfire data and ancillary datasets, we analyze and map the extensive wildfire exposure in the Eastern United States and compare it with spatial metrics of social vulnerability and community resilience to examine the social burdens of wildfire exposure in the Eastern U.S. A discernible wildfire exposure pattern emerges, with the Southeast bearing the highest exposure levels, largely attributed to human-caused and prescribed burning. By establishing a measure of disadvantaged counties using social vulnerability and community resilience, we identify regions where wildfire exposures could have the most adverse impact—areas characterized by highly vulnerable populations and limited community capacity to respond effectively to potential events. In evaluating wildfire risk, we conclude that considering not only exposure levels but also the inclusion of disadvantaged areas (incorporating social vulnerability and community resilience) is essential for understanding the disparate impact of wildfires on individuals and the communities where they live.
Preliminary Investigation towards the Use of Infrared Technology for Raw Milk Treatment
Authors: Danesi Luigi , Nobile Maria , Fontana Mauro , Tirloni Erica , Chiesa Luca Maria , Savini Federica , Villa Roberto Edoardo , Panseri Sara
Published: April 2024

Infrared (IR) technology offers a promising solution for reducing microbiological loads in various food types while preserving their quality traits, such as flavour. However, research on IR’s application in complex matrices is limited. Therefore, our preliminary study aimed to evaluate its effectiveness in sanitizing bovine raw milk. We assessed the bacterial count before and after IR treatment by comparing volatile organic compound profiles via headspace extraction and GC/MS analysis. Our findings showed that higher energy levels led to a greater bacterial reduction. IR85 was the most effective in reducing Coliforms and Enterobacteriaceae in non-homogenised samples, with a reduction ranging from −1.01 to >−2.99 and from −1.66 to −3.09 Log CFU/mL, respectively. IR60 and 70 showed no efficacy, while IR80 had intermediate but still satisfactory effect. IR85 notably affected volatile compounds, particularly increasing hexanal (from 0.08 to 4.21 ng g−1) and dimethyl sulphone (from 10.76 to 26.40 ng g−1), while IR80 better preserved the aroma profile. As a result, only IR80 was tested with homogenised raw milk, demonstrating significant bacterial reduction (from >2.39 to 3.06 Log CFU/mL for Coliforms and from 1.90 to >2.45 Log CFU/mL for Enterobacteriaceae) and maintaining the aroma profile quality.
Residue Degradation and Risk Assessment of Difenoconazole and Its Metabolite during Tea Growing, Processing and Brewing by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry Determination
Authors: Wang Min , Ning Yating , Hu Yue , Cui Xinyi , Luo Fengjian , Zhou Li , Yu Miao , Zhang Xinzhong
Published: April 2024

Residue dissipation and risk assessment of difenoconazole and its metabolite difenoconazole-alcohol during tea growing, processing, and brewing was first investigated by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). The limits of quantification for both difenoconazole and difenoconazole-alcohol were 0.001 mg/kg in fresh tea leaves and tea, and 0.0002 mg/L in tea infusion. In field trials, the dissipation half-lives of difenoconazole in fresh tea leaves was 1.77 days. After spraying, the residues of difenoconazole-alcohol increased and then gradually dissipated like difenoconazole. After 14 days, the dissipation rates of difenoconazole and difenoconazole-alcohol reached 99%. When fresh tea leaves were harvested on different days, the total processing factors (PFs) of difenoconazole and difenoconazole-alcohol for green tea were 0.86–1.05 and 0.78–0.85, respectively, while the total PFs for black tea were 0.83–1.13 and 0.82–1.66, respectively. Metabolism of difenoconazole was accelerated during tea processing. When brewing black tea, the leaching rates (LRs) of difenoconazole and difenoconazole-alcohol were 8.4–17.9% and 31.8–38.9%, respectively, while when brewing green tea, the LRs were 15.4–23.5% and 30.4–50.6%, respectively. The LRs of difenoconazole and difenoconazole-alcohol in black tea were higher than those in green tea. The potential threat to human health for dietary intake of difenoconazole and difenoconazole-alcohol residues from tea consumption is negligible. However, the dietary risk of difenoconazole in fruits and vegetables that are essential for daily diets is concerning, with a risk probability of 158%.
Application of Pomace Powder of Black Carrot as a Natural Food Ingredient in Yoghurt
Authors: Stoica Florina , Rațu Roxana Nicoleta , Motrescu Iuliana , Cara Irina Gabriela , Filip Manuela , Țopa Denis , Jităreanu Gerard
Published: April 2024

Researchers and food manufacturers are investigating the use of fruit and vegetable by-products as nutrient-dense food ingredients in response to increasing consumer requests for healthier and more natural foods. Black carrot (Daucus carota L.), a root vegetable variety of deep purple carrot, is a valuable source of nutrients with excellent health benefits and nutraceutical effects. Black carrot pomace (BCP), a by-product of industrial juice extraction, is abundant in bioactive compounds, dietary fiber, antioxidants, and pigments such as anthocyanins. Value addition and sustainability are perspectives provided by using this underutilized agricultural by-product in food applications. With an emphasis on BCP powder’s effects on phytochemical and physicochemical qualities, mineral and color characteristics, and sensory aspects, this study aims to assess the effects of adding BCP powder to yogurt formulations. The findings show that the addition of BCP powder improved the nutritional, and the color of the yogurts, providing a visually appealing product. Moreover, adding the BCP powder raised the amount of phytochemicals and the antioxidant activity in the final product’s formulation. The manufacturing of such products can not only aid in promoting sustainable food production but also offer consumers a wider range of innovative food options with improved properties.
Assessing the Effect of Cold Plasma on the Softening of Postharvest Blueberries through Reactive Oxygen Species Metabolism Using Transcriptomic Analysis
Authors: Zhang Can , Cheng Jun-Hu
Published: April 2024

The postharvest softening and corresponding quality deterioration of blueberry fruits are crucial factors that hinder long-distance sales and long-term storage. Cold plasma (CP) is an effective technology to solve this, but the specific mechanism of delaying fruit softening remains to be revealed. Here, this study found that CP significantly improved blueberry hardness. Physiological analysis showed that CP regulated the dynamic balance of reactive oxygen species (ROS) to maintain hardness by increasing antioxidant content and antioxidant enzyme activity, resulting in a 12.1% decrease in the H2O2 content. Transcriptome analysis revealed that CP inhibited the expression of cell wall degradation-related genes such as the pectin hydrolase gene and cellulase gene, but up-regulated the genes of the ROS-scavenging system. In addition, the resistance genes in the MAPK signaling pathway were also activated by CP in response to fruit ripening and softening and exhibited positive response characteristics. These results indicate that CP can effectively regulate the physiological characteristics of blueberries at a genetic level and delay the softening process, which is of great significance to the storage of blueberries.
Weissella cibaria Relieves Gut Inflammation Caused by Escherichia coli through Inflammation Modulation and Gut Microbiota Regulation
Authors: Liu Xiaoyu , Jiang Nan , Wang Xinyue , Yan Haowen , Guan Lili , Kong Lingcong , Chen Jingrui , Zhang Haipeng , Ma Hongxia
Published: April 2024

The emergence of multi-drug-resistant (MDR) pathogens has considerably challenged the development of new drugs. Probiotics that inhibit MDR pathogens offer advantages over chemical antibiotics and drugs due to their increased safety and fewer side effects. This study reported that Weissella cibaria P-8 isolated from pickles showed excellent antibacterial activity against intestinal pathogens, particularly the antibacterial activity against MDR Escherichia coli B2 was the highest. This study showed that the survival rates of W. cibaria P-8 at pH 2.0 and 0.3% bile salt concentration were 72% and 71.56%, respectively, and it still had antibacterial activity under pepsin, trypsin, protease K, and catalase hydrolysis. Moreover, W. cibaria P-8 inhibits the expression of inflammatory factors interleukin-1β, tumor necrosis factor-α, and interleukin-6, upregulates the interleukin-10 level, and increases total antioxidant capacity and superoxide dismutase enzyme activity in serum. W. cibaria P-8 also efficiently repairs intestinal damage caused by E. coli infection. The gut microbiota analysis demonstrated that W. cibaria P-8 colonizes the intestine and increases the abundance of some beneficial intestinal microorganisms, particularly Prevotella. In conclusion, W. cibaria P-8 alleviated MDR E. coli-induced intestinal inflammation by regulating inflammatory cytokine and enzyme activity and rebalancing the gut microbiota, which could provide the foundation for subsequent clinical analyses and probiotic product development.
Functionality and Health-Promoting Properties of Polysaccharide and Plant-Derived Substances from Mesona chinensis
Authors: Seah Romson , Siripongvutikorn Sunisa , Wichienchot Santad , Usawakesmanee Worapong
Published: April 2024

Mesona chinensis, in Thai called Chao Kuay and in Chinese Hsian-tsao, belongs to the Lamiaceae family. This herbal plant grows widely in Southern China, Taiwan (China), Malaysia, the Philippines, Indonesia, Vietnam, and Thailand. The Mesona plant is used to make functional products such as drinks and soft textured sweet treats, and also traditional medicine, to treat heat stroke, high blood pressure, heart attack, high blood sugar, hepatic diseases, colon diseases, inflammatory conditions, and to alleviate myalgia. The proximate composition of M. chinensis is a mixture of protein, fat, fiber, ash, and minerals. The main biological compounds in M. chinensis extracts are polysaccharides, terpenoids, flavonoids, and polyphenols, with wide-ranging pharmacological properties including antioxidant, antidiabetic, antilipidemic, carcinoma-inhibitory, renal-protective, antihypertensive, DNA damage-protective, and anti-inflammatory effects. This review investigated the proximate composition, polysaccharide type, and pharmacological properties of M. chinensis extracts. Phytochemical properties enhance the actions of the gut microbiota and improve health benefits. This review assessed the functional and medicinal activities of M. chinensis extracts. Future studies should further elucidate the in vitro/in vivo mechanisms of this plant extract and its impact on gut health.
Chemical Composition and Geographic Variation of Cold Pressed Balanites aegyptiaca Kernel Oil
Authors: El Harkaoui Said , El Kaourat Asma , El Monfalouti Hanae , Kartah Badr Eddine , Mariod Abdalbasit Adam , Charrouf Zoubida , Rohn Sascha , Drusch Stephan , Matthäus Bertrand
Published: April 2024

With the increasing impacts of climate change, establishing more sustainable and robust plants such as desert dates (Balanites aegyptiaca) seems to be necessary. Known for its resilience in arid conditions, this tree has the potential to become a more important food source, particularly for its potential to yield edible oil. This study characterized Balanites kernel oil (BKO) as a promising oil source in arid regions, studying the influence of geographical origin and environmental factors. Moroccan and Sudanese BKO samples were analyzed and compared with Mauritanian BKO. In the fatty acid profile, unsaturated fatty acids constituted over 70% of the BKO profile, with a predominance of linoleic acid (Li), oleic acid (Ol), palmitic acid (Pa), and stearic acid (St). Consequently, the predominant triacylglycerols were PaLiLi, PaLiOl, LiLiOl, OlLiOl, and StLiOl. α-Tocopherol dominated the tocochromanol composition (324 to 607 mg/kg), followed by γ-tocopherol (120 to 226 mg/kg), constituting 90% of the total tocochromanols. The total phytosterol content in BKO ranged from 871 to 2218 mg/kg oil, with β-sitosterol dominating (58% to 74%). Principal Component Analysis revealed that the geographical origin significantly influences BKO composition, emphasizing environmental factors, particularly water deficit and/or temperatures. Notably, Moroccan BKO collected from an area characterized by high aridity and relatively low winter temperatures, showcased a unique profile in fatty acid, phytosterols, and tocochromanols. The valorization of BKO presents an opportunity for local agricultural development in arid regions and a role model for plant development and agricultural practices in other parts of the world.
Chemical Profile Characterization of Fruit and Vegetable Juices after Fermentation with Probiotic Strains
Authors: Mantzourani Ioanna , Nikolaou Anastasios , Kourkoutas Yiannis , Alexopoulos Athanasios , Dasenaki Marilena , Mastrotheodoraki Artemis , Proestos Charalampos , Thomaidis Nikolaos , Plessas Stavros
Published: April 2024

Lactic acid bacteria (LAB) are widely applied for fermentation purposes in dairy and non-dairy food matrices with beneficial technological and health-promoting properties. This study describes the effect of two lactic acid bacteria, namely, Lactiplantibacillus paracasei SP5 and Pediococcus pentosaceus SP2, on the phenolic profiles, antioxidant activities, total phenolic content (TPC), carotenoid content, and sensorial profile of two different mixed fruit juices. After 48 h of fermentation, both LABs retained viability over 9 Log CFU/mL in both juices. The TPC, zeaxanthin + lutein, β-carotene content, and antioxidant activity (AA) were elevated for both LABs and mixed juices after 48 h of fermentation compared to control samples. Regarding the phenolic profile, both juices exhibited a significant decrease in chlorogenic acid levels, while quinic acid and tyrosol concentrations showed notable increases.
Correction: Sirpal et al. Association between Opioid Dependence and Scale Free Fractal Brain Activity: An EEG Study. Fractal Fract. 2023, 7, 659
Authors: Sirpal Parikshat , Sikora William A. , Azizoddin Desiree R. , Refai Hazem H. , Yang Yuan
Published: April 2024

Desiree R. Azizoddin PsyD from the TSET Health Promotion Research Center, Stephenson Cancer Center at the University of Oklahoma Health Sciences Center, USA, was not included as an author in the original publication [...]
Surface-Enhanced Raman Spectroscopy (SERS) for Identifying Traces of Adenine in Organic-Bearing Extraterrestrial Dust Analogs Captured in the Tanpopo Aerogel after Hypervelocity Impacts
Authors: Percot Aline , Mahieddine Farah , Yano Hajime , Hasegawa Sunao , Tabata Makoto , Yamagishi Akihiko , Mita Hajime , Paredes-Arriaga Alejandro , Maurel Marie-Christine , Lambert Jean-François , Baklouti Donia , Zins Emilie-Laure
Published: April 2024

Raman spectroscopy is a non-destructive analytical technique for characterizing organic and inorganic materials with spatial resolution in the micrometer range. This makes it a method of choice for space-mission sample characterization, whether on return or in situ. To enhance its sensitivity, we use signal amplification via interaction with plasmonic silver-based colloids, which corresponds to surface-enhanced Raman scattering (SERS). In this study, we focus on the analysis of biomolecules of prebiotic interest on extraterrestrial dust trapped in silica aerogel, jointly with the Japanese Tanpopo mission. The aim is twofold: to prepare samples as close as possible to the real ones, and to optimize analysis by SERS for this specific context. Serpentinite was chosen as the inorganic matrix and adenine as the target biomolecule. The dust was projected at high velocity into the trapping aerogel and then mechanically extracted. A quantitative study shows effective detection even for adenine doping from a 5·10−9mol/L solution. After the dust has been expelled from the aerogel using a solvent, SERS mapping enables unambiguous adenine detection over the entire dust surface. This study shows the potential of SERS as a key technique not only for return samples, but also for upcoming new explorations.
A Novel In Vitro Pathological Model for Studying Neural Invasion in Non-Melanoma Skin Cancer
Authors: Ávila-Fernández Paula , Etayo-Escanilla Miguel , Sánchez-Porras David , Blanco-Elices Cristina , Campos Fernando , Carriel Víctor , García-García Óscar Darío , Chato-Astrain Jesús
Published: April 2024

Neural Invasion (NI) is a key pathological feature of cancer in the colonization of distant tissues, and its underlying biological mechanisms are still scarcely known. The complex interactions between nerve and tumor cells, along with the stroma, make it difficult to reproduce this pathology in effective study models, which in turn has limited the understanding of NI pathogenesis. In this study, we have designed a three-dimensional model of NI squamous cell carcinoma combining human epidermoid carcinoma cells (hECCs) with a complete peripheral nerve segment encapsulated in a fibrine-agarose hydrogel. We recreated two vital processes of NI: a pre-invasive NI model in which hECCs were seeded on the top of the nerve-enriched stroma, and an invasive NI model in which cancer cells were immersed with the nerve in the hydrogel. Histological, histochemical and immunohistochemical analyses were performed to validate the model. Results showed that the integration of fibrin-agarose advanced hydrogel with a complete nerve structure and hECCs successfully generated an environment in which tumor cells and nerve components coexisted. Moreover, this model correctly preserved components of the neural extracellular matrix as well as allowing the proliferation and migration of cells embedded in hydrogel. All these results suggest the suitability of the model for the study of the mechanisms underlaying NI.
The Effect of Spacer Treatment of Infected Hip and Knee Arthroplasties on Patients’ Mental Health: A Narrative Review of the Literature
Authors: Di Gennaro Donato , Coletta Giannantonio , Festa Enrico , De Mauro Domenico , Rizzo Maria , Diana Luca , Balato Giovanni , Mariconda Massimo
Published: April 2024

Background: The gold standard treatment for periprosthetic joint infections is the two-stage revision that includes the spacer placement before definitive reimplantation. The management of PJI affects patients’ joint function and, subsequently, their mental health. Even though significant advances have been achieved, little to no attention has been paid to the psychological implications. So, based on standardized patient-reported outcome measures (PROMs), this study aimed to clarify the effect of spacer treatment of infected hip and knee arthroplasties on patients’ mental health. Methods: We performed research on the literature on PJIs in the English language using the MEDLINE database with the search strings “spacer” OR “spacers” AND “hip” OR “knee” AND “SF-12” OR “SF-36” OR “EQ-5” OR “mental” OR “depression” OR “anxiety.” The reference lists of selected articles were also hand-searched for any additional articles. Results: A total of 973 published papers were extracted, and 9 papers were finally included. A total of 384 patients who underwent spacer placement for PJI were identified. Of these 384 patients, 54% were female. The mean age ranged from 62 to 78.2 years. Of the11 papers identified for this review, 4 analyzed only hip spacers, including 119 patients; 4 only knee spacers, evaluating 153 patients; while a single study included 112 patients for both joints. Conclusions: Patients with the spacer are living in a state of mental upset, albeit better than the preoperative state. Clinical improvement with the review is not assured. The alteration of mental state turns out not to be transient for all the patients.
Predictive Validity of the Johns Hopkins Fall Risk Assessment Tool for Older Patients in Stroke Rehabilitation
Authors: Hong Seungho , Kim Ji-Sook , Choi Young-Ah
Published: April 2024

The aim of this retrospective, cross-sectional, observational study was to assess the frequency of falls and evaluate the predictive validity of the Johns Hopkins Fall Risk Assessment Tool (JHFRAT) among patients aged ≥65 years, transferred to the rehabilitation ward of a university hospital. The predictive ability was assessed using receiver operating characteristic curve analysis, and the optimal threshold was established using the Youden index. We analyzed the overall cohort (N = 175) with subacute stroke and the subgroup with a low unaffected handgrip strength (HGS; men: <28 kg, women: <18 kg). Overall, 135/175 patients (77.1%) had a low HGS. The fall rate was 6.9% overall and 5.9% for patients with a low HGS. The JHFRAT predictive value was higher for patients with a low HGS than that for the overall cohort, but acceptable in both. The optimal cutoff score for the overall cohort was 11 (sensitivity, 67%; specificity, 68%), whereas that for the subgroup was 12 (sensitivity, 75%; specificity: 72%). These results are expected to aid nurses working in rehabilitation wards in more effectively utilizing JHFRAT outcomes for post-stroke older patients with a low HGS and contribute to the development of more appropriate fall prevention strategies for high-risk patients in the future.
The Right to Equal Health: Best Practice Priorities for Māori with Bipolar Disorder from Staff Focus Groups
Authors: Haitana Tracy , Clark Mau Te Rangimarie , Crowe Marie , Cunningham Ruth , Porter Richard , Pitama Suzanne , Mulder Roger , Lacey Cameron
Published: April 2024

Bipolar disorder (BD) is a serious mental health condition that is clinically complex to monitor and manage. While best practice guidelines exist, they vary internationally lacking consensus. Indigenous peoples, including Māori in New Zealand, experience higher community rates of BD. While New Zealand practice guidelines recommend providing culturally responsive care to Māori, studies show that Māori do not receive best practice. This qualitative study aimed to share the evidence about patterns of health service use and Māori patient experiences with focus group participants involved in the design and delivery of BD services, to discuss and develop guidelines for best practice for Māori with BD and address areas of unmet need. Three focus groups were conducted with 22 participants involved in the delivery of services to Māori with BD across three sites. Willing participants were sent background information and three focus group questions framed to elicit priority solutions to improve clinical, structural and organisational features of mental health service delivery for Māori patients with BD and their whānau (family). The nominal group technique was used to synthesise responses, and then develop a prioritised list of proposed solutions. Results identified system-level changes required at the clinical, structural and organisational levels of healthcare. Findings further evidence the need for healthcare reform in New Zealand, to be responsive to Māori with BD.
Sexual Self Discrepancies, Sexual Satisfaction, and Relationship Satisfaction in a Cross-Sectional Sample of Women Who Experience Chronic Vaginal Pain during Sexual Intercourse
Authors: Moore Elizabeth , Sitron Justin
Published: April 2024

One out of three women may suffer from chronic vaginal pain during intercourse, a complex health issue that leads to lasting psychological, sexual, emotional, and relational difficulties even after initial relief. Women who experience this pain condition may compare their sexual selves to the societal norm of being pain-free. Comparisons that do not align with one’s actual sexual self result in sexual self-discrepancies and may cause emotional distress. Sexual self-discrepancies may hinder sexual and relationship satisfaction for women who experience chronic vaginal pain during sexual intercourse. This mixed-method study examined the sexual self-discrepancies women reported and the degree to which their sexual self-discrepancies were related to their sexual and relationship satisfaction. Results from this cross-sectional study showed that the majority of participants experienced sexual self-discrepancies and that they experienced a significant inverse correlation between sexual self-discrepancies and sexual satisfaction. In multivariate models, sex frequency was the strongest predictor of sexual satisfaction. There were no correlations between sexual self-discrepancies and relationship satisfaction. Future measurement research should examine the role of sex frequency in the experience of sexual satisfaction. Education on maximizing pleasure and minimizing pain may aid women to cope with the negative impact of pain.
Comparative Outcomes of Levetiracetam and Phenobarbital Usage in the Treatment of Neonatal Seizures: A Retrospective Analysis
Authors: Toptan Handan Hakyemez , Karadag Nazmiye Nilgun , Topcuoglu Sevilay , Ozalkaya Elif , Dincer Emre , Cakir Hakan , Gunes Asli Okbay , Karatekin Guner
Published: April 2024

Objectives and Aim: The primary aim of this study was to conduct a comparative analysis of the safety and efficacy of levetiracetam (LEV) and phenobarbital (PB) as first-line treatments for neonatal seizure management. This study was designed to measure and compare the incidence of adverse effects and to determine the discharge and mortality rates associated with the use of these antiseizure medications (ASMs). Through this comparison, this research sought to provide insights to optimise care for neonates experiencing seizures. Materials and Methods: This retrospective cohort study evaluated 104 neonates treated for seizures at Zeynep Kamil Hospital from 2015 to 2020 after excluding those on non-PB/LEV antiseizure medications. Seizures were characterised using electroencephalogram (EEG) and categorised according to aetiology and frequency. Treatment efficacy was gauged by seizure cessation, as confirmed using EEG. Adverse effects and demographic data were recorded. Statistical analyses were conducted using SPSS, employing the Shapiro–Wilk, independent t-test, Mann–Whitney U test, and chi-square test, with a significance threshold of p < 0.05. Results: Overall, 104 neonates treated with first-line ASM were evaluated for efficacy; PB was administered in 68.26% of the cases, while LEV was utilised in 31.74%. The total complete response rate was 40.38%, with no significant difference between the PB and LEV groups (p = 0.309). The incidence rate ratios (IRRs) demonstrated that seizure frequency profoundly influenced treatment effectiveness, with IRRs of 2.09 for rare seizures, 3.25 for frequent seizures, and 4.01 for status epilepticus, indicating a higher treatment response rate with increasing seizure frequency. For second-line treatment, among a subset of 62 patients, PB had a slight, non-significant advantage over LEV, with an odds ratio of 1.09, suggesting a marginally better response to LEV. Adverse events were significantly more frequent in the PB group, affecting 19 of 67 neonates (28.36%), compared to only 2 of 71 neonates (2.82%) in the LEV group (p < 0.001). No significant difference was observed in the discharge rates between the two groups (PB, 67.61%; LEV, 75.76%; p = 0.674). Interestingly, the mortality rate was significantly higher in the LEV group (45.45%) than that in the PB group (22.54%; p = 0.045). Conclusion: This study underscores LEV’s superior safety profile over PB in neonatal seizure management, evidenced by a significantly lower rate of adverse events. PB seems to be more effective in the second-line treatment of neonatal seizures. Despite the lack of significant differences in the discharge rates, the higher mortality rate associated with LEV warrants further investigation. These findings advocate the cautious selection of antiepileptic drugs in neonatal care, with a preference for LEV based on its safety profile.
Development and Validation of the Interprofessional Collaboration Practice Competency Scale (IPCPCS) for Clinical Nurses
Authors: Chou Yen-Fang , Hsieh Suh-Ing , Tseng Yi-Ping , Yeh Shu-Ling , Chiang Ming-Chu , Hsiao Chia-Chi , Lin Chiu-Tzu , Hu Shui-Tao , Chen Sue-Hsien , Liao Mei-Nan
Published: April 2024

Interprofessional collaborative practice is a core competency and is the key to strengthening health practice systems in order to deliver safe and high-quality nursing practice. However, there is no Interprofessional Collaboration Practice Competency Scale (IPCPCS) for clinical nurses in Taiwan. Therefore, the purposes of this study were to develop an IPCPCS and to verify its reliability and validity. This was a psychometric study with a cross-sectional survey using convenience sampling to recruit nurses from the seven hospitals of a medical foundation. A self-designed structured IPCPCS was rolled out via a Google survey. The data were analyzed using descriptive statistics, principal-axis factoring (PAF) with Promax rotation, Pearson correlation, reliability analysis, and one-way ANOVA. PAF analysis found that three factors could explain 77.76% of cumulative variance. These were collaborative leadership and interprofessional conflict resolution, interprofessional communication and team functioning, and role clarification and client-centered care. The internal consistency of the three factors (Cronbach’s α) was between 0.970 to 0.978, and the Pearson correlation coefficients were between 0.814 to 0.883. Significant differences were presented in the IPCPCS score by age, education level, total years of work experience, position on the nursing clinical ladder, and participation in interprofessional education. In conclusion, the three factors used in the IPCPCS have good reliability and construct validity. This scale can be used as an evaluation tool of in-service interprofessional education courses for clinical nurses.
Drivers of COVID-19 Outcomes in Long-Term Care Facilities Using Multi-Level Analysis: A Systematic Review
Authors: Karimi-Dehkordi Mehri , Hanson Heather M. , Silvius James , Wagg Adrian
Published: April 2024

This study aimed to identify the individual, organizational, and environmental factors which contributed to COVID-19-related outcomes in long-term care facilities (LTCFs). A systematic review was conducted to summarize and synthesize empirical studies using a multi-level analysis approach to address the identified influential factors. Five databases were searched on 23 May 2023. To be included in the review, studies had to be published in peer-reviewed journals or as grey literature containing relevant statistical data. The Joanna Briggs Institute critical appraisal tool was employed to assess the methodological quality of each article included in this study. Of 2137 citations identified after exclusions, 99 records met the inclusion criteria. The predominant individual, organizational, and environmental factors that were most frequently found associated with the COVID-19 outbreak comprised older age, higher dependency level; lower staffing levels and lower star and subset domain ratings for the facility; and occupancy metrics and co-occurrences of outbreaks in counties and communities where the LTCFs were located, respectively. The primary individual, organizational, and environmental factors frequently linked to COVID-19-related deaths comprised age, and male sex; higher percentages of racial and ethnic minorities in LTCFs, as well as ownership types (including private, for-profit, and chain membership); and higher occupancy metrics and LTCF’s size and bed capacity, respectively. Unfolding the risk factors collectively may mitigate the risk of outbreaks and pandemic-related mortality in LTCFs during future endemic and pandemics through developing and improving interventions that address those significant factors.
An Original UV Adhesive Watermelon Grafting Method, the Grafting Device, and Experimental Verification
Authors: Zhang Xin , Kong Linghao , Lu Hanwei , Feng Qingchun , Li Tao , Zhang Qian , Jiang Kai
Published: April 2024

This study is aimed at traditional vegetable grafting using a large number of plastic clips, which cannot be recycled in time and cause serious pollution within the planting environment. This paper proposes a new grafting method based on a UV adhesive instead of plastic clips. First of all, a UV adhesive spray grafting device was designed. The structure includes seedling adsorption positioning mechanisms, a butt joint mechanism, a handling mechanism, a spray valve, a UV curing lamp, etc., to facilitate the adhesive spraying. For the rootstock and scion, a horizontal, lateral seedling and negative pressure adsorption and positioning method is adopted, with fluid dynamics simulation of the diameter and quantity of the adsorption holes in the rootstock adsorption mechanism carried out using Fluent 2022 R1 software and completion of the optimization of the parameters of the adsorption and positioning mechanism. The fluid volume method is used to simulate the adsorption and positioning mechanism. For optimization, the volume of fluid method (VOF) and the discrete particle method (DPM) are used in a coupled simulation of the UV adhesive spraying process, and the value range of the spraying influencing factors is determined: the selected glue pressure, atomization pressure, and spraying height for three-factor, three-level orthogonal simulation. A grafting test is also verification, deriving the significance ranking of their impact on the success rate of the grafting: atomization pressure > spraying height > glue pressure. Under the condition of a 0.25 Mpa atomization pressure, a 0.15 Mpa glue supply pressure, and a 10 mm spraying height, the grafting success rate for watermelon was 100%, the effective spraying rate was 83.03%, the healing success rate was 94.5%, and the length of the film was 7.86 mm. The results of the study can provide a research basis for the research and development of new types of spraying and grafting robot technology.
Assessing the Genetic Diversity of Wild and Commercial Feijoa sellowiana Accessions Using AFLPs
Authors: Bini Lorenzo , Gori Massimo , Novello Maria Angelina , Biricolti Stefano , Giordani Edgardo , Lara María Valeria , Niella Fernando , Nunziata Angelina , Rocha Patricia , Filippi Jacopo Mattia , Natale Roberto
Published: April 2024

Feijoa sellowiana (O. Berg) is a broadly widespread fruit tree species at a very early stage of domestication. Although appreciated for its flavored berries rich in nutrients and nutraceuticals, and as an ornamental plant, feijoa is still considered an underutilized species and little information is available about its genetic background, cultivar traceability and divergence. This study aimed to investigate, for the first time, the genetic diversity of feijoa through the application of AFLPs. Specifically, twenty cultivars from different countries and six wild types (WTs) from their area of origin (Misiones, Argentina) were analyzed. The AFLPs proved to be informative, revealing the values of the percentage of polymorphic loci (PPB), Nei’s genetic diversity (h), and the Shannon index (I) at 69.36%, 0.27, and 0.43, respectively, consistent with the average of long-lived perennial and outcrossing species. However, despite the limited number of WTs examined, the genetic variability (h) was higher (approximately 37%) within the six samples compared to cultivars. The population structure analysis identified three clusters, with WTs forming a separated cluster (III) as expected. Cultivars were divided into two clusters (I and II), with cluster I exhibiting a closer genetic proximity to WTs compared to cluster II. This finding was further confirmed using the UPGMA dendrogram based on Provesti distances. This work raised awareness of the genetic variability among the feijoa’s widespread cultivars and demonstrated that the limited genetic breeding programs over the last decades resulted in low diversity among them. Moreover, these results confirm the hypothesis that all varieties are derived from a single narrow ancestral population. The potential of this species is considerable and needs to be further investigated to exploit its peculiarities.
Synergizing Sustainability and Financial Prosperity: Unraveling the Structure of Business Profit Growth through Consumer-Centric Strategies—The Cases of Kosovo and Albania
Authors: Lulaj Enkeleda , Dragusha Blerta , Hysa Eglantina , Voica Marian Catalin
Published: April 2024

This research investigates the synergistic relationship between sustainability and financial prosperity in businesses, specifically focusing on the impact of consumers on profit growth in Kosovo and Albania. The study aims to understand consumers’ perceptions of their purchases, the factors influencing their choice of businesses, and the types of businesses that effectively support consumers in these countries. Data were collected through a survey completed by 200 consumers and 200 businesses. The analysis, utilizing multivariate analysis of variance, descriptive analysis, and reliability analysis with SPSS, reveals that consumers significantly influence the sustainability of business profit growth. Moving forward, it is recommended that businesses prioritize offering reasonable prices, quality products/services, easy access to products/services, clear information about products/services, and convenient locations. The research has profound implications for businesses, consumers, and countries and suggests the need for further exploration of the impact of consumers on profit growth in diverse contexts.
Variability of Extreme Climate Events and Prediction of Land Cover Change and Future Climate Change Effects on the Streamflow in Southeast Queensland, Australia
Authors: Pakdel Hadis , Chadalavada Sreeni , Alam Md Jahangir , Paudyal Dev Raj , Vazifedoust Majid
Published: April 2024

The severity and frequency of extremes are changing; thus, it is becoming necessary to evaluate the impacts of land cover changes and urbanisation along with climate change. A framework of the Generalised Extreme Value (GEV) method, Google Earth Engine (GEE), and land cover patterns’ classification including Random Forest (RF) and Support Vector Machine (SVM) can be useful for streamflow impact analysis. For this study, we developed a unique framework consisting of a hydrological model in line with the Process-informed Nonstationary Extreme Value Analysis (ProNEVA) GEV model and an ensemble of General Circulation Models (GCMs), mapping land cover patterns using classification methods within the GEE platform. We applied these methods in Southeast Queensland (SEQ) to analyse the maximum instantaneous floods in non-stationary catchment conditions, considering the physical system in terms of cause and effect. Independent variables (DEM, population, slope, roads, and distance from roads) and an integrated RF, SVM methodology were utilised as spatial maps to predict their influences on land cover changes for the near and far future. The results indicated that physical factors significantly influence the layout of landscapes. First, the values of projected evapotranspiration and rainfall were extracted from the multi-model ensemble to investigate the eight GCMs under two climate change scenarios (RCP4.5 and RCP8.5). The AWBM hydrological model was calibrated with daily streamflow and applied to generate historical runoff for 1990–2010. Runoff was projected under two scenarios for eight GCMs and by incorporating the percentage of each land cover into the hydrological model for two horizons (2020–2065 and 2066–2085). Following that, the ProNEVA model was used to calculate the frequency and magnitude of runoff extremes across the parameter space. The maximum peak flood differences under the RCP4.5 and RCP8.5 scenarios were 16.90% and 15.18%, respectively. The outcomes of this study suggested that neglecting the non-stationary assumption in flood frequency can lead to underestimating the amounts that can lead to more risks for the related hydraulic structures. This framework is adaptable to various geographical regions to estimate extreme conditions, offering valuable insights for infrastructure design, planning, risk assessment, and the sustainable management of future water resources in the context of long-term water management plans.