bluuebunny/crossref_metadata_2025 huggingface dataset:
Stubborn Sets, Frozen Actions, and Fair Testing
Authors: Valmari Antti , Vogler Walter
Published: January 2021

Many partial order methods use some special condition for ensuring that the analysis is not terminated prematurely. In the case of stubborn set methods for safety properties, implementation of the condition is usually based on recognizing the terminal strong components of the reduced state space and, if necessary, expanding the stubborn sets used in their roots. In an earlier study it was pointed out that if the system may execute a cycle consisting of only invisible actions and that cycle is concurrent with the rest of the system in a non-obvious way, then the method may be fooled to construct all states of the full parallel composition. This problem is solved in this study by a method that “freezes” the actions in the cycle. The new method also preserves fair testing equivalence, making it usable for the verification of many progress properties.
COMPARISON OF PERCUTANEOUS NEPHROLITOTOMY (PCNL) IN PRONE AND SUPINE POSITION: A SINGLE CENTRE EXPERIENCE REPORT
Authors: Safriadi Ferry , Ramdhan Dadan
Published: January 2021

Objective: This study aims to compare outcomes of supine percutaneous nephrolithotomy to prone percutaneous nephrolithotomy as a traditional approach in Hasan Sadikin Hospital Bandung. Material & Methods: Data was taken from urology’s database between 2003-2012, which contain data of prone position (2003-2007), and supine position (2008-2012). Three hundred forty-nine patients were included in this study. We reviewed data on demography, stone burden, operating time, stone-free rate, transfusion rate, hospital stay, and major complications. Results: Of 174 patients underwent prone position, and 175 patients were part of the supine position. Age means of prone position was 51.0 years old, the supine position was 50.5 years old. The number of male patients was 65.5% for prone, and 66.1% for supine. The mean stone's largest diameter of prone was 23.87 mm, supine was 22.36 mm. The operating time of prone was 107 minutes; supine was 90 minutes. The stone-free rate of prone was 94.7%; supine was 91.3%. The mean hospital stays of prone was 14.3 days; supine was 9.6 days. The transfusion rate of prone position was 8.9%, supine was 7.2%. No major complications were recorded. Conclusion: Higher stone-free rates are achieved with patients in the prone position during PCNL. Supine position has shorter operating time, and hospital stay, lower blood transfusion rates. The complication rate is not different between the two positions.
HYPERTENSION EFFECTS ON THE DECREASED KIDNEY FUNCTION PROGRESIVITY IN BENIGN PROSTATIC HYPERPLASIA PATIENTS
Authors: Dhiemas Trisyuananda Eniestama  , Aziz Ayu Munawaroh , Wahyudi Septa Surya
Published: January 2021

Objective: A comprehensive knowledge about BPH and hypertension is needed to reduce morbidity and mortality in patients with decreased kidney function due to the two diseases. Material & Methods: This research used the observational analytics method with cross-sectional design. This research used secondary data from medical records of BPH patients in Bina Sehat Hospital and Paru Hospital from January 1st to December 1st 2019. Results: Comparative serum creatinine test results in hypertensive BPH patients with non-hypertensive BPH patients using the Mann Whitney test, obtained p= 0.000. Based on these results it can be concluded that there are significant differences in serum creatinine between hypertensive BPH patients and non-hypertensive BPH patients. Correlation test results using the Spearman test between serum creatinine with blood pressure systole and diastole all samples obtained each p= 0.000 r= 0.399 for systolic blood pressure and p= 0.000 r= 0.337 for diastole blood pressure. Based on these results it can be concluded that there is a significant correlation between serum creatinine with systolic and diastolic blood pressure of the patient. Conclusion: Hypertension will worsen the kidney function decline in BPH patients seen from an increase in serum creatinine.
COMPARISON OF PAIN INTENSITY BETWEEN LIDOCAINE GEL AND INTRAURETRAL TRAMADOL WITH LIDOCAINE GEL IN THE DJ STENT REMOVAL
Authors: Wijayanto Cahyo , Doddy M. Soebadi  , Djatisoesanto Wahjoe
Published: January 2021

Objective: To determine the difference in pain intensity between the administration of a combination of tramadol and intraurethral lidocaine gel with only lidocaine gel during the removal of DJ stents. Material & Methods: This study was a prospective randomized clinical trial with 22 patients that were divided into 2 groups. Group 1 was given a combination of tramadol and lidocaine gel urethral injection 3 to 5 minutes before DJ stent removal, whereas group 2 was given lidocaine gel urethral injection 3-5 minutes before the removal. The inclusion criteria in this study was all patients with a DJ stent placement with 1 to 3 months prior to release who were willing to participate. The Wong-Baker scale was used directly to determine the scale of pain during the procedure. Mann Whitney analysis was used to analyze the findings. Results:  Most patients in group 1 are shown to have a pain rating of 2. There are 2 patients with a high pain rating scale of 6 and 7. In group 2, most patients claimed that the procedure was painless. The average Wong-Baker pain scale in group 1 (2.9) compared to group 2 (0.36) was significantly different. Conclusion: The combination of intraurethral tramadol and 2% lidocaine gel can significantly decrease pain during DJ stent removal more effectively than sole intraurethral 2% lidocaine gel based on the Wong-Baker pain scale.
EFFECT OF PERIURETHRAL INJECTION ADIPOSE-DERIVED STEM CELLS IN NERVE HEALING AND VOIDING BEHAVIOR FOR THE TREATMENT OF STRESS URINARY INCONTINENCE IN A RAT MODEL
Authors: Rizaldi Fikri , Purwati  , Sandhika Willy , Budiono  , Hardjowijoto Sunaryo
Published: January 2021

Objective: To investigate whether ADSCs are capable of nerve repair in stress urinary incontinence. Material & Methods: Thirty rats were allocated to five groups for receiving a periurethral injection with Phosphate Buffer Saline (PBS) (B1,B2) and Adipose-derived Stem Cells (C1, C2). Functional assessments with Voided Stain on Paper (VSOP) Method were reassessed at 2 and 4 weeks after injection. The rat SUI model was generated by Vaginal Distention (VD). The regeneration of peripheral nerve was evaluated by PGP 9.5 immunohistochemical staining. Results: Results revealed significant peripheral nerve differences between ADSC group and other groups in 28 days using PGP 9.5 staining. Our functional assessment, Voided Stain on Paper (VSOP), showed that ADSC group had significant improvement in 14 days; unfortunately, our 28 days improvement was not substantial. Conclusion: Periurethral injection of ADSCs improves urine pattern in SUI-induced rats and increase the amount of peripheral nerve. This method may be a potential strategy for SUI treatment.
Strategi optimalisasi program dana desa melalui pemberdayaan masyarakat dalam perspektif ekonomi Islam
Authors: Mitra Zuana Muhammad Mujtaba , Muawanah  , Dian Rahmawati
Published: January 2021

The village fund provides a very important position for the village to carry out development and community empowerment programs. These include programs for the welfare of the community. Village funds have an important role in improving the economy of rural communities, with effective and efficient use and allocation. This study uses field research with descriptive research methods, the methods used in this study are: observation, structured interviews, and documentation. After the researchers have collected data, the next step is to do the data analysis. The analysis conducted by researchers uses two ways, namely processing the initial data and classifying it and then the next stage of the data will be analyzed. Based on the results of this study it can be concluded that the management of village funds in the village of Kemiri has been running in accordance with existing technical guidelines, so that the development in the village of Kemiri from the existence of village funds has brought considerable changes starting from improving infrastructure facilities, educational advice, health facilities etc. but in the field of empowerment in the village of Kemiri is still not optimal this is due to the lack of community participation in the management of village funds. In the field of development and empowerment, the community is only involved in planning and implementation, but in terms of accountability and evaluation of the community village fund program, it has not been directly involved.
Benefícios fiscais e gasto tributário no ICMS, espécies e métodos de mensuração
Authors: Frota da Silveira Rodrigo , Gradvohl Michel André Bezerra Lima
Published: January 2021

Tendo em vista o elevado gasto tributário anual dos estados brasileiros e do Distrito Federal referentes a benefícios fiscais concedidos com base no ICMS, resulta a necessidade de mensurar adequadamente estes valores e controlar os seus resultados. A complexidade e diversidade da legislação tributária e dos benefícios relativos ao ICMS têm sido fortes empecilhos à construção de modelos adequados a mensurar tais renúncias fiscais. Este estudo tem por objetivo identificar, por meio de pesquisa qualitativa, espécies de benefícios fiscais com este imposto e desenvolver metodologias capazes de mensurar o montante de recursos públicos renunciados em cada modalidade identificada. O método aplicado foi a busca da Constituição e Leis Complementares no site do planalto e da legislação do ICMS, nos sites das administrações tributárias estaduais. Após a leitura, foram selecionadas apenas as normas referentes a benefícios fiscais. A pesquisa identificou padrões, divididos em famílias, gêneros e espécies, de benefícios fiscais com ICMS, assim como descreveu métodos de quantificação dos valores renunciados em cada modalidade. Os resultados obtidos são um primeiro passo no caminho para desenvolver uma metodologia que possibilite aos órgãos de controle aferir a relação de custo-benefício de cada modalidade de benefício deferido.
Avanços e Desafios no Controle do Tabagismo: um Paralelo entre o Mundo e o Brasil
Authors: Bettcher Douglas William , Silva Vera Luiza da Costa e
Published: January 2021

The aim of this opinion session is to contextualize the Brazilian program within the current international tobacco control efforts, and highlight its successful outcomes that have clearly resulted in a smoking prevalence reduction over the last 20 years. It also explores the new country challenges, highlighting the importance of tobacco control in the national and global development agenda.
Polimorfismos Genéticos nos Receptores Nicotínicos e Câncer de Pulmão: uma Visão Geral
Authors: Marqui Alessandra Bernadete Trovó de , Bonfim Vera Lúcia , Ruiz Mariangela Torreglosa
Published: January 2021

Introdução: O câncer de pulmão é o mais comum de todos os tumores malignos. Responsável por 20.485 mortes, em 2008, no Brasil, e, em 90% dos casos diagnosticados, está associado ao consumo de derivados de tabaco. A nicotina é o componente primário do tabaco presente no cigarro e, variantes genéticas nos genes que codificam subunidades do receptor de acetilcolina nicotínico participam na etiologia e progressão do câncer de pulmão. Objetivo: Realizar uma revisão sobre o câncer de pulmão e polimorfismos de nucleotídeos únicos em genes codificadores de subunidades dos receptores de acetilcolina nicotínicos. Método: Foi realizada uma revisão bibliográfica por meio de busca eletrônica na base de dados PubMed, tendo como limites artigos publicados nos últimos cinco anos, publicação em língua inglesa e pesquisas em seres humanos. Resultados: A região 15q25 que contém os polimorfismos de nucleotídeos únicos dos genes CHRNA5, CHRNA3 e CHRNB4 está associada a risco de câncer de pulmão e dependência a nicotina. Os trabalhos selecionados mostraram forte associação dos polimorfismos de nucleotídeos únicos 1192G>A e 645C>T dos genes CHRNA5 e CHRNA3, respectivamente com câncer de pulmão. Outros polimorfismos localizados em 15q25 associados a esse tipo de câncer incluem: 24289A>G, 28757T>C, 14621A>C, 10611T>C e 5539C>G do gene CHRNA5; 27011C>T, 3393G>A, 30238C>T do gene CHRNA3 e o 49711634C>G do gene CHRNB4. Conclusão: Os trabalhos publicados evidenciaram que, na investigação de polimorfismos, devem ser considerados a etnicidade e o efeito funcional daquela variante para o funcionamento e expressão gênica..
RESEARCH OF RAILWAY TRANSPORTATION OF FREIGHT BY GROUP AND SINGLE CARS
Authors: Gaba V. , Strelko O. , Hrushevska T. , Gusar I.
Published: January 2021

The influence of the existing conditions of operational work at transportation of cargoes by group and single cars is investigated. An analysis of modern approaches to improving the efficiency of the car fleet and the competitiveness of railway transport in the transport market of Ukraine. The most perspective approaches and directions of improvement of cargo delivery systems are allocated. A study of the efficiency of the organization of transportation by the criterion of total car-hours of downtime under accumulation. A mathematical model of chemical cargo transportation by carriage, group shipments and transportation of container trains with accumulation to technical norms of trains in the directions of transportation has been developed. The efficiency of two models of chemical cargo shipment organization is compared and a more efficient transportation option is identified. It is established that for more efficient use of rolling stock and reduction of car turnover there is transportation of goods in cars as a part of a container train. The influence of the components of the car turnover on its final value is analyzed. A study of the cost of transportation of benzene in tanks and tank containers in some areas. According to research, the cost of transporting benzene in tank containers on railway ownership platforms is twice less than in private tanks and tanks of Ukrzaliznytsia fleet. These recommendations will improve the process of transportation and increase the volume of goods by rail.
Sistem Informasi Akademik Berbasis Web Di Madrasah Aliyah Muhamadiyah Jasinga
Authors: Anik Muhamad , Fatimah Fety , Fajri Hersanto
Published: January 2021

SISTEM INFORMASI AKADEMIK BERBASIS WEB DI MADRASAH ALIYAH MUHAMADIYAH JASINGA merupakan lembaga pendidikan yang hingga saat ini proses pencatatan data masih secara manual dan menyebabkan MA Muhamadiyah mengalami kesulitan dalam melakukan kegiatan mencari data siswa, data guru, jadwal mata pelajaran dan transkip nilai, Sehingga akan memperlambat kinerja staf TU untuk membuat informasi secara cepat. Sistem informasi akademik ini menggunakan metode waterfall yang mempunyai beberapa proses yaitu proses requirement definition, system and software design, implementation and unit testing, integration and system testing yang berfungsi sebagai rancangan pembuatan sistem untuk memenuhi kebutuhan pengguna dan sistem yang dibuat ini menggunakan DBMS (database management system) sebagai tempat penyimpanan data sekolah. Untuk mengatasi masalah tersebut perlu adanya suatu sistem informasi yang terkomputerisasi.
PENGUKURAN KUALITAS PERANGKAT LUNAK PRODI TEKNIK INFORMATIKA UIKA BOGOR MENGGUNAKAN ISO 9126
Authors: Pratama Lutfi
Published: January 2021

Pencapaian kualitas perangkat lunak dapat dinilai melalui pengukuran. Ada banyak atribut-atribut perangkat lunak yang dapat diukur. Jumlah atribut yang digunakan dalam pengukuran tergantung pada banyaknya informasi yang ingin diperoleh melalui pengukuran. Contohnya, ketika seorang menejer proyek ingin memperoleh informasi mengenai tingkat kehandalan dari perangkat lunak yang dikembangkan maka atribut-atribut yang diukur adalah seperti jumlah kesalahan yang mungkin terjadi dalam kurun waktu tertentu, jumlah fungsi, jumlah baris kode, kerumitan, dan ujicoba yang dilakukan untuk memastikan tingkat kesalahan yang mungkin terjadi selama proses pengembangan perangkat lunak. Pada akhirnya informasi-informasi tersebut akan digunakan untuk mendukung fungsi-fungsi manajemen seperti perencanaan, pengorganisasian, pelaksanaan, dan pengendalian. Banyaknya standar kualitas yang ada saat ini menunjukkan bahwa begitu pentingnya pencapaian sebuah kualitas. Pentingnya kualitas perangkat lunak memang masih diperhadapkan pada banyaknya standar kualitas yang ada. Para ahli rekayasa perangkat lunak tampaknya masih memerlukan sedikit waktu untuk menetapkan sebuah standar tunggal yang dapat menggugurkan standar-standar kualitas yang banyak ini. Di sisi lain, pencapaian kualitas perangkat lunak tidak bisa menunggu sampai standar tunggal itu ditetapkan. Tujuan dari penelitian yaitu mendapatkan nilai kualitas perangkat lunak Prodi Teknik Informatika Uika Bogor. Penelitian ini dilakukan dengan teknik kuantitatif. Penelitian ini adalah penerapan dari teori-teori mengenai kualitas perangkat lunak, dan dilakukan sebagai pembuktian teori-teori tersebut. Secara skematik, metode penelitian dilakukan dengan beberapa tahapan kumpulan data dan analisis. Hasil yang diperoleh berupa pengumpulan data pada perangkat lunak, perhitungan indikator kualitas ISO 9126 yang meliputi indikator kualitas reliabilitas, indikator kualitas effisiensi. Berdasarkan hasil tersebut, maka ditarik kesimpulan sesuai tujuan penelitian dengan pengujian indikator kualitas ISO 9126 menyatakan perangkat lunak tersebut baik.
ANALISA SPASIAL CLUSTERING ZONASI RAWAN BENCANA TANAH LONGSOR WILAYAH BOGOR SELATAN BERBASIS WEB-GIS
Authors: Suwardi Ambi Mahdin
Published: January 2021

Tanah Longsor merupakan gerakan massa tanah pembentuk lereng. Penyebab dan sifat dari gerakan massa tanah atau longsor umumnya tidak bisa terlihat, karena penyebabnya tertutup oleh endapan geologi dan sistem air tanah. Wilayah Kabupaten Bogor Selatan merupakan kawasan dengan intensitas kejadian longsor yang tinggi selama lima tahun terakhir. Daerah yang di maksud adalah Kecamatan Ciawi, Kecamatan Caringin, Kecamatan Cijeruk, dan Kecamatan Cigombong. Tujuan dari penelitian ini adalah mengidentifikasi faktor yang berpengaruh terhadap peluang terjadinya longsor, zonasi wilayah berdasarkan tingkat kerawanan longsor, serta menganalisis hubungan antara faktor mekanika tanah dengan tingkat kerawanan. Analisis spasial dilakukan dengan sistem informasi geografis (SIG) dan menggunakan metode clustering k-means. Berdasarkan sebaran spasial, faktor curah hujan, jenis batuan, kemiringan lahan, dan penggunaan lahan merupakan faktor dominan yang dapat memicu kejadian longsor dengan peluang yang tinggi.
SISTEM INFORMASI PROMOSI DAN PEMESANAN PAKAIAN BERBASIS WEB PADA JASKO ANNAZMA MOSLEM WEAR CIGOMBONG – INDONESIA
Authors: Haryanto Adi
Published: January 2021

Jasko An Nazma Moslem Wear merupakan perusahaan konveksi yang bergerak di bidang produk dan jasa pembuatan pakaian muslimyang berlokasi di Jalan Bata Alam Kec.Cigombong Kab.Bogor. Pengalaman menekuni bidang usaha sejak 2015 hingga sekarang. Perusahaan ini berkonsentrasi pada penjualan pakaian muslim seperti Jasko, peci, gamis dan almamater namun kegiatan jual beli masih dilakukan secara manual, pemasaran dan promosi produk hanya mencakup area yang terbatas dan hanya mengandalkan sistem pemasaran dengan pemesanan melalui telepon dan pengenalan produk masih dilakukan secara offline. untuk melihat informasi mengenai produk yang dibutuhkan, pelanggan harus datang ke lokasi usaha untuk mengetahui informasi secara detail. Untuk menigkatkan pelayanan jasa yang mereka tawarkan kepada pelanggan Jasko An Nazma Moslem Wear memerlukan sistem informasi secara online berbasis web agar produknya lebih dikenal serta membuat sistem database penjualannya. Perancangan sistem pada Jasko An Nazma Moslem Wear dibangun berdasarkan (1) analisa sistem (2) perancangan sistem, (3) implementasi sistem. Analisa sistem pengumpulan data dengan carapengamatan kegiatan transaksi jual beli, wawancara terhadap pemilik usaha dalam hal penjualan dan dokumentasi untuk pengarsipan data yang didapat dari pemilik usaha yang diperlukan dalam pengembangan sistem. Perancangan sistem dibuat melalui tahapan diagram konteks (DFD level 0), DFD level 1), entity relationship diagram (ERD), desain input dan output serta struktur menu program. Implementasi sistem menggunakan program Microsoft visio, sublime text, adobe photoshop dan XAMPP server. Diharapkan sistem ini dapat membantu Jasko An Nazma Moslem Wear dalam meningkatkan kinerja perusahaan baik bertambahnya pelanggan, omset naik dan mempermudah sistem administrasinya.
THE INFLUENCE OF AMINO ACID NUTRITION ON THE PRODUCTIVITY OF RAINBOW TROUT
Authors: Kondratiuk Vadym
Published: January 2021

The article considers the effectiveness of complete feed with different levels of lysine and methionine for growing rainbow trout up to 10 g. The experiment aimed to establish the effect of different levels of amino acid nutrition of trout on its productivity. For this purpose, five experimental groups of this year were formed by the method of analogues. The experiment lasted 45 days and was divided into two periods: equalization (5 days) and main (40 days). During the equalization period, the experimental fish consumed feed of the control group. In the main period, the level of lysine and methionine in experimental feeds for different experimental groups of trout ranged from 2.8 to 3.2 % and from 0.90 to 1.10 %, respectively.

As a result of research, it was found that the use of trout weighing up to 10 g of feed with high amino acid nutrition (3.1 % lysine, 1.05 % methionine) in the feeding of this year is accompanied by an increase in their weight by 9.2 % (p <0.05) and growth intensity - by 4.1-9.3 %, compared with analogues who consumed feed with the content of lysine of 3.0% and methionine of 1.0%. The reduction of these amino acids to the levels of 2.8 and 0.9 %, respectively, contributes to a probable decrease (p <0.01) in the weight of fish by 14.1 %, and a decrease in growth intensity by 8.7-17.3 %.

It was proved that different levels of amino acid nutrition of young trout significantly (p <0.01) affected the weight of experimental fish. The share of influence of this factor is 61.4 %, which is 22.8 % more than the influence of other factors.

In the course of research, it was determined that when growing rainbow trout this year up to 10 g, feeding them compound feeds with lysine and methionine content of 3.1 and 1.05% helps to reduce feed costs per unit weight gain by 12.5 %, compared with using feeds with levels of these amino acids of 2.8 and 0.9 %, respectively. At the same time, the safety of the experimental fish throughout the experiment corresponded to the normative indicators in trout farming and was in the range of 76.0-77.3 %.

The analysis of the obtained fish farming results showed that for the production of trout products according to the indicators of maximum productivity and economic optimization criteria it is recommended to use complete feed with a level of 3.1% lysine and 1.05% methionine for feeding rainbow trout.
GENETIC DIVERSITY OF SIMMENTAL CATTLE LINES BY POLYMORPHIC BLOOD GROUP SYSTEMS
Authors: Rossokha Vladimir , Drobyazko Oksana , Boyko Yelena , Tur Grigoriy , Oliinychenko Elizabeth , Zaderikhina Yelena , Brovko Aleksey
Published: January 2021

Marking the cattle populations by individual genes and gene complexes createsnew opportunities for the development of selection when genetic methods aim to prevent the decrease of the populations’ gene variability. The article reveals the studies of the genetic structure of the Simmental cattle population, PAT breeding facility "Chervoniy Veleten" for erythrocyte antigens of 9 genetic systems (A, B, C, F, J, L, M, S, Z); linear affiliation of animals was taken into account.

Animal erythrocyte antigens were determined by hemolysis reaction using monospecific sera - reagents. It is established that the spectrum of certain antigens is specific for Simmental cattle. The high frequency of antigenic factors G2, T2, E3/, G/, I/, O/, Q/, B// (q = 0,364 - 0,636) let us identify allele markers inherent in Simmental cattle: BGKE/G/O/Q/, BGKE/O/, BGO/, G2O2Y2, as well as OQ/, OI/Q/, TV /P/.

The analysis of the of the most numerous factory lines (Neolit, Lavra, Zorkiy, Biser, Lascar) was carried out. It was shown that the markers of the Neolit line can be considered as the alleles: BOI'Q'(q = 0.2931) and BOTG`K` (q = 0.2392), Lavra - BBIA`K` (q = 0.1863) and BO` (q = 0.2500), Zorkiy - ВBGO` (q = 0.1325) and Вb, Biser - ВOI`Q` (q = 0.2246) and BG/ (q = 0.1920), Lascara - ВBGKE`GÒ `Q` (q = 0.1405) and BO` (q = 0.2735).

It was found, that alleles EAB, which are more common for Laurel and Lascar lines (Kv=32.04%) are marked by the most similarities in the alleles of the EAB - blood group system, the highest values of the difference coefficient are characteristic of the Neolit - Lascar and Neolit - Laurel lines (55.66% and 54.86% respectively), the most differentiated was the Neolit line (Kv ser. = 49.48%, dser. = 0.332). Detection of interlinear differences in related groups of Simmental cattle allows preliminary prediction, correction and plan the animal selection for factory mating.
La Experiencia de la Reserva Legal en Brasil: Una Opción de Conservación en Propiedades Rurales.
Authors: Trejo Pedro , Azevedo-Ramos Claudia
Published: January 2021

La Reserva Legal (RL) es un instrumento de protección el cual busca conservar una parte de los recursos naturales en propiedades rurales de Brasil. Desde hace casi un siglo ha sido centro de debates entre productores agropecuarios y ambientalistas. Siendo este un instrumento peculiar de Brasil, a través de una revisión bibliográfica, en este estudio se busca explicar el proceso de evolución de la RL en Brasil con base en su contribución, incluso para la agricultura. Actualmente, parte de los productores apoyan la permanencia de la RL como respuesta a mercados más exigentes con el medio ambiente. Ya habiéndose superado el 100% del registro de dichas áreas y con un cumplimiento del 80% la RL empieza a cumplir su función. La mejor comprensión de este instrumento nos permite evaluar su potencialidad para ser utilizada como herramienta para la conservación en diferentes países.
Educação em Direitos Humanos em debate
Authors: Fernandes Ana , Lopes Igreja Beatriz , Rego Carlos Eduardo , Gomes Gabriela , Figueiredo Ivanilda , Oliveira Natalia , Passos Pâmella , Ferreira Vinicius
Published: January 2021

Transcrição do debate Educação em Direitos Humanos realizado em 16 de setembro de 2020, em uma live durante a Pandemia de Covid-19, através da parceria entre o LAEDH – Laboratório de Educação em Direitos Humanos do Colégio Pedro II e  a Agência Espaço e Vida, que contou com as participações de Natália Braga Oliveira, professora de Sociologia do Colégio Pedro II e colaboradora do LAEDH; Vinicius Cavalcanti Ferreira, professor de Geografia da Educação Básica vinculado à à Espaço e Vida, que realiza atividades de turismo pedagógico e atividades de campo, voltadas para alunos do Ensino Fundamental e do Ensino Médio, e que mantém um canal no Youtube, que possibilitou a transmissão do presente debate em seu programa semanal, o Roda Espaço e Vida; Pâmella Passos, professora de História do Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ), onde integra o GPTEC - Grupo de Pesquisa em Tecnologia, Educação & Cultura, que possui produção voltada para práticas de Educação em Direitos Humanos e Ivanilda Figueiredo, professora de Direitos Humanos da Faculdade de Direito da Universidade do Estado do Rio de Janeiro (UERJ), onde integra o URDIR – Núcleo Multidisciplinar de Ensino, Pesquisa e Extensão Universidade, Resistência  e Direitos Humanos, no âmbito do qual possui iniciativas para Educação em Direitos Humanos. Este debate foi transcrito por Carlos Eduardo Oliva de C. Rêgo, professor de Sociologia do Colégio Pedro II e integrante do LAEDH, e por Ana Fernandes, Beatriz Lopes Igreja e Gabriela Prado Gomes, três estudantes da Faculdade de Direito da UERJ que atuam como colaboradoras voluntárias do LAEDH.
Além do senso comum: ensino de Sociologia e conhecimento científico
Authors: Fontes Barbara
Published: January 2021

Chegamos à 26ª edição da Perspectiva Sociológica: A revista de professores de Sociologia no final desse difícil, triste e enlutado ano de 2020. Infelizmente, muitas das questões e incertezas trazidas no nosso editorial de julho ainda permanecem tanto no que se refere à educação quanto às políticas públicas para esse cenário pandêmico. Além de todos os desafios decorrentes do aumento da precariedade das condições de vida de muitos brasileiros e brasileiras, temos que lidar com angústias relacionadas ao medo do contágio pela COVID-19, à falta de um plano consistente de vacinação quando temos quase 200 mil mortos somente no Brasil e, não menos problemático, a um negacionismo em relação à ciência.Nesse cenário angustiante e delicado, publicações como a nossa e a Sociologia como disciplina escolar possuem grande importância para a desconstrução de determinados sensos comuns e para a compreensão das etapas e do rigor que caracterizam o conhecimento científico. Isso posto, esta edição, intitulada Além do senso comum: ensino de Sociologia e conhecimento científico, traz em suas diversas seções reflexões pautadas pelo conhecimento da tríade das Ciências Sociais sobre temas muito presentes no senso comum, como família, direitos humanos, violência e arte de rua.
Sociologia: formação de conceitos e problematização das práticas sociais
Authors: Do Desterro Fábio Braga
Published: January 2021

Sociologia: formação de conceitos e problematização das práticas sociais, publicado pela editora Blucher em 2019, foi escrito por Davisson Souza e Débora Goulart, sociólogos e professores da UNIFESP e membros do Grupo de Estudos e Pesquisas Educação, Classes e Conflitos Sociais. É parte da coleção A reflexão e a prática no Ensino Médio, que tem como proposta oferecer metodologias e encaminhamentos pedagógicos que possam contribuir com o trabalho dos docentes atuantes nesta etapa da Educação Básica.
INFLUÊNCIA DA NATAÇÃO EM CRIANÇAS E ADOLESCENTES ASMÁTICOS: UM ESTUDO DE REVISÃO
Authors: Faes Andressa , Balbé Giovani Pereira
Published: January 2021

A asma é uma doença pulmonar obstrutiva crônica caracterizada por uma inflamação nas vias aéreas que limita a passagem do ar até os pulmões. Este estudo tem como objetivo analisar, através de uma revisão crítica, os efeitos da natação na asma em crianças e adolescentes. Foram utilizados artigos originais brasileiros encontrados nas bases de dados Bireme, Scielo e Google Acadêmico, abrangendo os temas asma e natação. A análise de dados incluiu pesquisas publicadas de 1997 a 2010, envolvendo indivíduos com idade entre cinco e 18 anos. Os resultados encontrados em relação à prática da natação e a asma foram positivos, apresentando melhoras no pico de fluxo expiratório, promovendo alterações favoráveis na função pulmonar e resistência respiratória, além da diminuição no número de crises. Conclui-se que a prática de exercícios de natação para crianças e adolescentes asmáticos proporciona diversos benefícios à saúde dessa população, melhorando o quadro da doença e auxiliando no seu tratamento.
PRACTICE OF PHYSICAL ACTIVITIES OF A MAN WITH POSITIVE RESULT FROM COVID 19
Authors: Krug Rodrigo de Rosso , Kupske Juliedy Waldow , Silva Leonardo Henrique da , Silva Juliano Schreiber da , Rasia Renan Felipe , Silva Patrícia Maiara Goulart da , Krug Moane Marchesan
Published: January 2021

Practicing physical activity is essential for physical and mental health. In addition, this behavior can be a great way to increase immunity, especially in times of the coronavirus pandemic (COVID-19). In this sense, this study aimed to analyze the practice of physical activities performed by a man with a positive result of COVID-19 during his period of social isolation, as well as his perceptions and difficulties about this practice. Qualitative case study carried out with a man from the northwest region of the state of Rio Grande do Sul with a positive diagnosis of COVID 19. For this, a questionnaire with open / closed questions was used as an instrument for data collection, the same was applied through the whatsapp and interpreted by content analysis. The participant reported that while in social isolation he practiced physical activities with his own body weight and with tools, in addition to abdominals. He performed them in his own room due to social isolation and had no symptoms during practice. In addition, he reported that the greatest difficulty was performing physical activities alone, without company, as usual in the weight training gym. Even in the face of such a singular moment, it is observed that the study participant followed an exercise routine, which can be explained by the adherence to the physical training that he has, and may have benefited in the recovery of the clinical condition during the diagnosis of Covid 19.
The management of patient with osteoporosis in clinical practice
Authors: Degli Esposti Luca , Giacomini Elisa , Ghigi Alessandro , Perrone Valentina
Published: January 2021

Osteoporosis is a systemic skeletal disorder characterized by increased bone fragility, which is associated with an enhanced fracture risk. The first fracture often represents indeed the clinical manifestation of this condition. In the present document we provided an overview of the economic and clinical impact of a not-adequate therapeutic appropriateness and suboptimal adherence to osteoporosis therapy, that are both widely reported in literature despite osteoporotic treatments have proved their efficacy in reducing fracture risk. Adequate treatment and adherence were reported to be associated with a lower risk of re-fracture and all-cause mortality. Moreover, healthcare costs in osteoporotic patients with previous fractures were significantly lower in those receiving osteoporosis treatment rather than among untreated patients. Nevertheless, these two key-factors are not improving over time. The measurement of indicators of adherence and therapeutic appropriateness allows to analyse the utilization profile of the drugs indicated for the treatment of osteoporosis and to evaluate the presence of possible deviation between the prescriptive behaviours observed in clinical practice and the recommendations reported in the guidelines. The periodic monitoring of such indicators together with prescribing audit activity could represent a useful tool for the optimization of osteoporosis management and to achieve a correct resource allocation. (Rheumatology)
OLGERD BOCHKOVSKYI: THE ATTITUDE OF THE CZECHS AND TOMÁŠ GARRIGUE MASARYK TO THE UKRAINIAN ISSUE
Authors: Pater Ivan
Published: January 2021

The author analyzes works of Olgerd Ipolyt Bochkovskyi about such "awakeners" of the Czech national revival as František Palacký, František Ladislav Rieger, Jan Koubek, Karel Havlíček Borovský, Karel Havík Janophiles who were Slavophiles and in individual actions Russophiles, but at the same time really and correctly assessed the Ukrainian issue, for the first time brought it to an international forum. They supported the Ukrainians' language and rights in 1849 in the Austrian post-revolutionary parliament against Polish and Russian fraud, the independence of the Ukrainian people among the Slavs. The "awakeners" were against Russian claims to the Ukrainian Galicia, Bukovina and Transcarpathia, the anti-Ukrainian policy of tsarism, and defended the leading role of Ukraine in the final settlement of inter-Slavic relations.

O. Bochkovskyi's journalistic activity in different European magazines is revealed. Special attention is paid to the coverage of the Ukrainian issue, the situation of Galician-Bukovynian Ukrainians, the national development of the Slavic peoples.

The ideological influence of the notable Czech scientist, public and political figure Tomáš Garrigue Masaryk on the scientific way of Olgerd Bochkovskyi as a sociologist and nationalist is highlighted. In the works of O. Bochkovskyi, it was emphasized that T. Masaryk, before the war interpreted the Ukrainian question, based primarily on the real content and vitality of the Ukrainian movement. He emphasized the absolute undoubted right of Ukrainians to self-determination and political independence. It is noted that concerning the Ukrainian issue T. Masaryk had mainly political reasons. It is stated that O. Bochkovskyi proved T. Masaryk's warnings against Ukraine's independence during the war by recent history and the adjustment of life. The author singled out tactics and methods of the Czechoslovak liberation action as the top of T. Masaryk's nation-building art, a perfect example for Ukraine in further liberation directions, the guarantee of the future triumph of Ukrainian independence.
Keywords: Olgerd Bochkovskyi, Tomáš Masaryk, Ukraine, Ukrainian issue, Ukrainians, Czechs, independence, statehood.
Physical education professor Stepan Haiduchok: the formation of a worldview
Authors: SOVA Andrii
Published: January 2021

The study presents the first attempt to highlight the formation of Stepan Haiduchok's (1890–1976) ideological orientations based on various sources: private archives of Stepan Haiduchok (Lviv), Klavdii Bilynskyi (Sydney) and Andrii Sova (Lviv); reports of the Lviv Academic Gymnasium; Stepan Haiduchok's personal file, which was preserved at Danylo Halytskyi Lviv National Medical University; periodical of the Ukrainian gymnastic society «Sokil» – «Visti z Zaporozha»; Ivan Boberskyi's works; the memoirs of persons who knew him directly or indirectly.

With the involvement of previously unavailable and little-known documents, his childhood and high school years were reconstructed. The author has demonstrated that Professor of the Lviv Academic Gymnasium Ivan Boberskyi (1873–1947), through the gymnastics classes (physical education), the activities of the Ukrainian Sports Club and the Sokil Gymnastic Society influenced the formation and choice of Stepan Haiduchok's future profession – a physical education teacher.

During the high school years were formed the basis, which let him express himself as an athlete, professor of Ukrainian physical education, public and cultural person, journalist, editor, student, and follower of the «Father of Ukrainian Physical Education». The research methodology based on general scientific principles of historical objectivity, systematicity, reliability, complexity, and scientific nature. By applying the biographical method, it was more likely to reveal the objectives of the study.
Keywords: Stepan Haiduchok, Lviv Academic Gymnasium, Ivan Boberskyi, worldview formation, body education, physical education, sport.
Epidemiology issues in problem of antibiotic resistance of clinical pathogens
Authors: Gabrielyan N. I. , Sharapchenko S. O. , Kisil O. V. , Kormilitsina V. G. , Drabkina I. V. , Safonova T. B. , Petrukhina M. I. , Saitgareev R. Sh. , Zakharevich V. M.
Published: January 2021

The relevance of the work is due to the increase in the number of hospital infections associated with antibiotic-resistant gram-negative pathogens on a global scale. For medical institutions, both from a clinical and economic point of view, the catastrophic situation is that the multidrug-resistant pathogens increasing leads to limited possible treatment options. Analysis of published scientific articles shows that today the strict epidemiological surveillance and the study of the pathogen resistance profile in each medical facility is an effective tool for controlling the growth of multidrug-resistant microorganisms, thus reducing morbidity and mortality.
Rationale for the use of a design of Emax CAD on an endodontically treated tooth. Clinical case
Authors: Urusov E. V. , Makarov A. L. , Kozlova Y. S.
Published: January 2021

Elimination of aesthetic and functional tooth disorders is one of the most popular areas in the daily practice of a dentist. The desire to achieve an ideal aesthetic result plays an important role in the choice of material for restoration. Replacing lost tooth tissues in aesthetically demanding patients is a very difficult task, for the dentist and for the restoration material.
Measurement of cortical plate volume based on CBCT of frontal teeth in studies with retrusion and normality
Authors: Meskhiya N. G. , Kopetskiy I. S. , Nikolskaya I. A. , Eremin D. A. , Kovaleva O. N.
Published: January 2021

Cone Beam Computed Tomography (CBCT) is the preferred imaging method for a comprehensive orthodontic examination. Thanks to the development of this technique, clinicians today can make most accurate measurements without fear of errors associated with projection distortion or localization of landmarks on radiographs. The quality of CBCT images gives to orthodontists the ability to analyze bone structures, teeth (even impacted teeth), and soft tissue in three dimensions. The accuracy of measurements of hard and soft tissues from CBCT images determines the accuracy of diagnosis and treatment planning. A fundamentally new approach has been proposed, which makes it possible to thoroughly study the bone tissue surrounding the tooth at the stages of planning orthodontic treatment. Аnalysis of radiation studies of patients with dentoalveolar anomalies was carried out to select the optimal treatment tactics and to control its effectiveness.
Multiple pyogenic granules of the face
Authors: Khimich I. V. , Kirpichnikov M. V. , Podolsky V. V. , Yarygina E. N. , Maksutin I. A. , Serbin A. S. , Dronov S. V. , Aleshanov K. A.
Published: January 2021

The prevalence and clinical features of multiple pyogenic granulomas of the face are discussed on the example of a clinical case. A treatment regimen for this pathology is presented and an assessment of its effectiveness is given.
New data of topographic anatomy of semilunar line (semilunar line by A. Spiegel)
Authors: Chernykh A. V. , Popova M. P. , Brigadirova V. Yu.
Published: January 2021

Background. Today, a special place in surgical practice is the treatment of patients with spigelian hernias, which can be subcutaneous, interstitial, prepperitoneal, and make up 1% of all external hernias of the abdomen. The difficulty in diagnosing of spigelian hernias can lead to a serious complication – infringement of the hernia, which will require emergency surgical treatment. Therefore, the study of the typical, sexual and variant anatomy of the Spigelian line region is important in improving the diagnosis and treatment of such patients.

The aim. To study the features of typical, sexual and variant anatomy of the Spigelian line region.

Materials and methods. We examined 42 non-fixed corpses of persons of both sexes without signs of pathology of the anterior abdominal wall. Among them were 26 (54.2%) men and 22 (45.8%) women. At autopsy, we performed anatomical dissection of the semilunar line region. We measured the width of the aponeurotic stretch from the end of the transverse abdominal muscle fibers to the lateral edge of the rectus abdominis muscle at level corresponding to d. bicostarum, umbilical ring and d. bispinarum.

Results. We identified four clusters corresponding to the variations in the shape of the semilunar line: tapering down (9.5%), uniform wide (19.0%), tapering up (28.6%) and wide in the middle (42.9%). We found that the semilunar line, tapering up, was significantly more often observed in women (83.3%), uniformly wide – in brachymorphic body type (75.0%), wide in the middle – in mesomorphic body type (66.07%), and the semilunar line, tapering down, was found only in men. Variants of the shape of the semilunar line, tapering up or down, were absent in persons of the brachymorphic body type. Semilunar line, tapering up, was found (without significant differences) in persons of the mesomorphic body type in 41.6%, in the persons of the brachymorphic body type – in 58.4%, and semilunar line, tapering down, was noted in persons with a dolichomorphic body type in 75.0%.

Conclusion. New data may allow to predict the location, type of spigelian hernia, and also improve the diagnosis and treatment of spigelian hernia.
Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway
Authors: Liang Chenyu , Liu Yang , Xu Huifeng , Huang Junling , Shen Yi , Chen Faxiu , Luo Ming
Published: January 2021

Background

Acute myocardial infarction (AMI) is one of the leading causes of morbidity and death worldwide. Studies have indicated that microRNAs in mesenchymal stem cell (MSC)-derived exosomes are crucial for treating various diseases.

Methods

Human umbilical cord MSC (hucMSC)-derived exosomes (hucMSC-exo) were isolated and used to treat cardiomyocytes that underwent hypoxia/reoxygenation (H/R) injury. Bioluminescence assessment was used to study binding of miRNA to its targeting gene.

Results

We found that H/R decreased the viability of AC16 cells, increased the expression of NLRP3, and activated caspase-1(p20) and GSDMD-N as well as release of IL-1β and IL-18, and such effects were abolished by administration of hucMSC-exo. Administration of exosomes from negative scramble miRNA (NC)-transfected hucMSCs blocked H/R-caused lactate dehydrogenase release, pyroptosis, and over-regulation of NLRP3 and activated caspase-1(p20) and GSDMD-N as well as release of IL-1β and IL-18. More importantly, in comparison to exsomes from NC-transfected hucMSCs, exsomes from miR-100-5p-overexpressing hucMSCs had more obvious effects, and those from miR-100-5p-inhibitor-transfected hucMSCs showed fewer effects. Functional study showed that miR-100-5p bound to the 3’-untranslated region (3’-UTR) of FOXO3 to suppress its transcription. Moreover, overexpression of FOXO3 abolished the protective effects of miR-100-5p.

Conclusion

Enriched miR-100-5p in hucMSC-exo suppressed FOXO3 expression to inhibit NLRP3 inflammasome activation and suppress cytokine release and, therefore, protected cardiomyocytes from H/R-induced pyroptosis and injury.
Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and Lymphoid Organs
Authors: Cichoń Małgorzata Anna , Klas Katharina , Buchberger Maria , Hammer Martina , Seré Kristin , Zenke Martin , Tschachler Erwin , Elbe-Bürger Adelheid
Published: January 2021

The endoplasmic reticulum-associated protein reticulon 1A (RTN1A) is primarily expressed in neuronal tissues but was recently identified also specifically in cells of the dendritic cell (DC) lineage, including epidermal Langerhans cells (LCs) and dermal DCs in human skin. In this study, we found that in mice major histocompatibility complex class II (MHCII)+CD207+LCs but not dermal DCs express RTN1A. Further, RTN1A expression was identified in CD45+MHCII+CD207+cells of the lymph node and spleen but not in the thymus. Of note, RTN1A was expressed in CD207lowLCs in adult skin as well as emigrated LCs and DCs in lymph nodes and marginally in CD207hicells. Ontogeny studies revealed that RTN1A expression occurred before the appearance of the LC markers MHCII and CD207 in LC precursors, while dermal DC and T cell precursors remained negative during skin development. Analogous to the expression of RTN1A in neural tissue, we identified expression of RTN1A in skin nerves. Immunostaining revealed co-localization of RTN1A with nerve neurofilaments only in fetal but not in newborn or adult dermis. Our findings suggest that RTN1A might be involved in the LC differentiation process given its early expression in LC precursors and stable expression onward. Further analysis of the RTN1A expression pattern will enable the elucidation of the functional roles of RTN1A in both the immune and the nervous system of the skin.