bluuebunny/crossref_metadata_2025 huggingface dataset:
Neutralizing epitope of the Fusion Protein of Respiratory Syncytial Virus Embedded in the HA Molecule of LAIV Virus is not Sufficient to Prevent RS Virus Pulmonary Replication but Ameliorates Lung Pathology following RSV Infection in Mice
Authors: Kotomina Tatiana , Isakova-Sivak Irina , Stepanova Ekaterina , Mezhenskaya Daria , Matyushenko Victoria , Prokopenko Polina , Sivak Konstantin , Kiseleva Irina , Rudenko Larisa
Published: June 2020

Aims:

To develop experimental bivalent vaccines against influenza and RSV using a cold-adapted LAIV backbone.

Background:

Respiratory syncytial virus (RSV) is a causative agent of bronchiolitis and pneumonia in young children, elderly and immunocompromised adults. No vaccine against RSV has been licensed to date for various reasons. One of the promising platforms for designing RSV vaccine is the use of live attenuated influenza vaccine (LAIV) viruses to deliver RSV epitopes to the respiratory mucosa.

Objective:

To generate recombinant LAIV viruses encoding a neutralizing epitope of the RSV fusion protein and assess their protective potential against both influenza and RSV infections in a mouse model.

Methods:

Reverse genetics methods were used to rescue recombinant LAIV+HA/RSV viruses expressing chimeric hemagglutinins encoding the RSV-F epitope at its N-terminus using two different flexible linkers. BALB/c mice were intranasally immunized with two doses of the recombinant viruses and then challenged with the influenza virus or RSV. The LAIV viral vector and formalin-inactivated RSV (FI-RSV) were included as control vaccines. Protection was assessed by the reduction of virus pulmonary titers. In addition, RSV-induced lung pathology was evaluated by histopathology studies.

Results:

Two rescued chimeric LAIV+HA/RSV viruses were identical to the LAIV vector in terms of replication capacityin vitroandin vivo. The RSV-F neutralizing epitope was successfully expressed only if inserted into the HA molecule via G-linker, but not A-linker. Both chimeric viruses induced high influenza-specific antibody levels and fully protected mice against a lethal influenza challenge virus. However, they induced weak anti-RSV antibody responses which did not prevent RS virus replication upon challenge, and only LAIV-HA+G-RSV variant protected mice against RSV-induced lung pathology.

Conclusion:

Although the designed LAIV-RSV chimeric viruses were unable to neutralize the RS virus pulmonary replication, the LAIV-HA+G-RSV reduced RSV-induced lung pathology and can be considered a promising bivalent vaccine against influenza and RSV infections and warrants its further development.
Transmodulation of Dopaminergic Signaling to Mitigate Hypodopminergia and Pharmaceutical Opioid-induced Hyperalgesia
Authors: Brewer Raymond , Blum Kenneth , Bowirrat Abdalla , Modestino Edward J. , Baron David , Badgaiyan Rajendra D. , Moran Mark , Boyett Brent , Gold Mark S.
Published: June 2020

Neuroscientists and psychiatrists working in the areas of “pain and addiction”
are asked in this perspective article to reconsider the current use of dopaminergic blockade
(like chronic opioid agonist therapy), and instead to consider induction of dopamine homeostasis
by putative pro-dopamine regulation. Pro-dopamine regulation could help pharmaceutical
opioid analgesic agents to mitigate hypodopaminergia-induced hyperalgesia by inducing
transmodulation of dopaminergic signaling. An optimistic view is that early predisposition
to diagnosis based on genetic testing, (pharmacogenetic/pharmacogenomic monitoring),
combined with appropriate urine drug screening, and treatment with pro-dopamine
regulators, could conceivably reduce stress, craving, relapse, enhance well-being and attenuate
unwanted hyperalgesia. These concepts require intensive investigation. However,
based on the rationale provided herein, there is a good chance that combining opioid analgesics
with genetically directed pro-dopamine-regulation using KB220 (supported by 43
clinical studies). This prodopamine regulator may become a front-line technology with the
potential to overcome, in part, the current heightened rates of chronic opioid-induced hyperalgesia
and concomitant Reward Deficiency Syndrome (RDS) behaviors. Current research
does support the hypothesis that low or hypodopaminergic function in the brain may
predispose individuals to low pain tolerance or hyperalgesia.
Analysis of Commission Forensic-medical Examinations performed in Cases Concerning the Responsibility of Surgical Professional Doctors
Authors: Kozan Natalia , Voloshynovych Volodymyr , Kotsyubynska Yuliia , Zelenchuk Halyna , Tsikhivskyi Andrii
Published: June 2020

The objective of the research was the analysis of the structure of the commission of forensic medical examinations concerning professional offenses of medical professionals of the surgical profile according to the data of the Ivano-Frankivsk Regional Bureau of Forensic Medical Expertise for the period 2015-2019.

Materials and methods. The material of the study were the annual reports of the Ivano-Frankivsk Regional Bureau of Forensic Medical Expertise (Commission Department) and criminal case materials. Obtained data were processed using Microsoft Exel, Statistica 6.0. 

Results. It was found that forensic medical examinations in case of improper performance of professional duties by medical workers accounted for a relatively small part 71 (14.3%) of the total forensic medical expertise. After the performed analysis, it was found that the doctors made diagnostic, therapeutic, organizational-tactical, deontological and combined errors that had a direct (29%) or indirect (26%) connection with the onset of death or adverse effects on the patient’s health. In 45% of cases, there was no correlation between the doctor’s actions and the occurrence of adverse effects for the patient.

Conclusions. The number of cases for improper performance of professional duties by medical workers is significantly higher in surgeons and obstetricians-gynecologists than in doctors of therapeutic profile. Every year, the complexity of commission forensic medical examinations in case of improper performance of professional duties by medical workers increases. This is due to the increasing complexity of surgical interventions and instrumental examination methods, as well as the increasing legal literacy of the population.
Aromatherapy and Quitting Smoking
Authors: Arslan Işık Nurten
Published: June 2020

Today, the treatment approaches recommended for smoking cessation are pharmacological and behavioral therapy. Both approaches are reported to be effective alone; however, when used together, the success rate increases. Modern medicine methods, however, often have a negative image due to cost, complexity and limitations in human life. For this reason, complementary and alternative therapies are widely used in the community for the treatment of many diseases in every age group. When people are asked why they prefer complementary and alternative therapies, the most important reason seems to be to improve quality of life by providing symptom control. Other reasons include economic problems, the lack of health insurance, the improvement of quality of life, the influence of the media and the environment, a strong belief that it will help, disappointment of conventional treatment failure, the noninvasiveness of most complementary and alternative therapies, fear of medical treatments, dissatisfaction with the current health system, medicines. Avoiding side effects can be called as a desire to have more control over health decisions. Contrary to many pharmacological and behavioral treatments that investigate the effectiveness of smoking cessation, only a few studies have included complementary and alternative treatments. Complementary treatment methods such as aromatherapy are thought to be regularly included in smoking cessation programs and their use should be ensured/expanded.
Long Non-Coding RNA MALAT1 Gene Polymorphism is Associated with Disease-Free Survival in Bladder Cancer Patients
Authors: Volkogon Andrii , Kolnoguz Olena , Harbuzova Viktoriia , Ataman Alexander
Published: June 2020

The objective of the research was to study the possible association between MALAT1 gene rs3200401 polymorphism and the survival of patients with bladder cancer and clinicopathological characteristics in bladder cancer.

Materials and Methods. The venous blood of 141 patients with transitional cell carcinoma of the urinary bladder was used for study. Genotyping of MALAT1 gene rs3200401 polymorphism was performed by real-time polymerase chain reaction using the 7500 Fast Real-Time PCR System (Applied Biosystems, Foster City, USA) and Taq-Man Assays (TaqMan® SNP Assay C_3246069_10). Statistical analysis was performed using the SPSS software package (version 17.0). The Kaplan-Meier estimator and Cox regression were used to check the possible association between MALAT1 rs3200401-genotypes and the age of transitional cell carcinoma of the urinary bladder onset. P values ​​< 0.05 were considered as statistically significant.

Results. The obtained results revealed that hemoglobin concentration was lower in patients with transitional cell carcinoma of the urinary bladder and rs3200401TT-genotype than in patients with rs3200401CC-genotype (p=0.024). Herewith, fasting glucose, creatinine concentration, and tumor width were significantly higher in patients with transitional cell carcinoma of the urinary bladder and rs3200401TT-genotype as compared to rs3200401CC-genotype carriers (p = 0.036, p = 0.039, p = 0.028, respectively). The results of survival analysis demonstrated that transitional cell carcinoma of the urinary bladder occurred much later in persons with rs3200401TT-genotype as compared to rs3200401C-allele carriers (log rank p = 0.016), and the risk of transitional cell carcinoma of the urinary bladder onset was lower in individuals with rs3200401TT than in major rs3200401C C-allele carriers (hazard ratio = 0.413; p = 0.047).

Conclusions. Rs3200401 polymorphism of MALAT1 gene is associated with disease-free survival in Ukrainian patients with transitional cell carcinoma of the urinary bladder. Transitional cell carcinoma of the urinary bladder occurs later in persons with rs3200401TT-genotype than in individuals with rs3200401CC- and rs3200401CT-genotypes.
Una Una aplicación tecnológica que ayuda a la ciudadanía a escribir textos a la Administración pública
Authors: Da Cunha Iria
Published: June 2020

En este trabajo se presenta una aplicación tecnológica gratuita y en línea que ayuda a la ciudadanía a escribir textos dirigidos a la Administración pública. Concretamente, ayuda a redactar cinco géneros textuales: alegación, carta de presentación, queja, reclamación y solicitud. La aplicación tiene forma de editor de textos e incluye tres módulos para: I) estructurar y añadir contenidos en el texto, II) corregirlo ortográficamente y darle formato, y III) obtener sugerencias de mejora sobre aspectos léxicos y discursivos. Integra diferentes herramientas de Procesamiento del Lenguaje Natural (PLN), como un analizador morfosintáctico y un segmentador discursivo. Las evaluaciones data-driven y user-driven realizadas ofrecen resultados positivos.
Documentary narrative for a new understanding of a stigmatized public space
Authors: Cyrulnik Natacha
Published: June 2020

Following on from an audiovisual project carried out over fifteen years in cities in the

South of France, the tourist sites are now being filmed as part of a new documentary series, in an

attempt to better understand daily life in these easily stigmatised areas by telling the story. The

aim is both to apprehend the public space from an urban (Paquot, 2009) and media (Habermas,

1978) point of view, in order to try to better understand it (Niney, 2000). The creative documentary

offers both a device (Agamben, 2007) and the possibility of sharing an experience through

art (Dewey, 1915) that encourages a sensitive approach to the tourist territory. It requires the narration

of a territory in images and sounds, whether through the words of tourists (Augé, 1997)

or travellers (Paquot, 2014) or through behaviour in “family films” (Odin, 1995), for example.

This narrative of a territory is based on the relationship that man establishes with the tourist site.

Thus, in a way, he fictionalises a reality by asserting a point of view. In this way, it allows a more or

less imaginary journey for the person who experiences it, as well as for the spectator in the end.
Temporal evolution of COVID-19 in the states of India using SIQR Model (Preprint)
Authors: Tiwari Alok
Published: June 2020

BACKGROUND

COVID 19 entered during the last week of April 2020 in India has caused 3,546 deaths with 1,13,321 number of reported cases. Indian government has taken many proactive steps, including strict lockdown of the entire nation for more than 50 days, identification of hotspots, app-based tracking of citizens to track infected.

OBJECTIVE

This paper investigated the evolution of COVID 19 in five states of India (Maharashtra, UP, Gujrat, Tamil Nadu, and Delhi) from 1st April 2020 to 20th May 2020

METHODS

Variation of doubling rate and reproduction number (from SIQR) with time is used to analyse the performance of the majorly affected Indian states

RESULTS

. It has been determined that Uttar Pradesh is one of the best performers among five states with the doubling rate crossing 18 days as of 20th May. Tamil Nadu has witnessed the second wave of infections during the second week of May. Maharashtra is continuously improving at a steady rate with its doubling rate reaching to 12.67 days. Also these two states are performing below the national average in terms of infection doubling rate. Gujrat and Delhi have reported the doubling rate of 16.42 days and 15.49 days respectively. Comparison of these states has also been performed based on time-dependent reproduction number. Recovery rate of India has reached to 40 % as the day paper is written.

CONCLUSIONS

All the three major contributing states of India as improving slowly. Tamil Nadu witnessed the second peak during mid of May, Maharasthra alongwith Tamil Nadu is performing below the national average. This kind of analysis can be useful for the analysis of evolution of COVID 19 among different states of India.
Investigation of Water-Flooding Activity Using Radiotracer Technology in Commercial Core-Flood Set Up
Authors: Othman Noraishah Binti , Saaid Ismail Mohd , Ahmed Afaque , Yusof Nazrul Hizam , Yahya Roslan , Mohd Yunos Mohd Amirul Syafiq , Engku Chik Engku Mohd Fahmi , Shari Mohamad Rabaie , Hassan Hearie , Mahmood Airwan Affandi
Published: June 2020

An intervention of radiotracer technology in the EOR program has been initiated using commercial core-flood set up. A commercial type of Berea core is used throughout the experiment. 99mTc is chosen as a radioactive tracer for this experiment, which has a half-life of 6 hours and emits gamma rays’ energy of 0.104MeV. It is a liquid radiotracer with the activity of 10GBq (270mCi), eluted and prepared by Institute Cancer of Malaysia (IKN) before transporting it to the laboratory at Centre of Research in Enhanced Oil Recovery (COREOR), Universiti Teknologi Petronas. The experiment was conducted after 3.5 half-lives. Thus the activity has reduced to approximately (1.48GBq) 40mCi during injection inside the system. The results can be used to assist the reservoir engineer in determining the exact water-tracer breakthrough, localize the location of water-tracer concerning time, and determine the residence time distribution and mean residence time of the core flood where the hydrodynamics of the flow can be predicted. Moreover, the introduction of radiotracer inside the core flood rig can be translated as secondary oil recovery. The idea is to integrate radiotracer technology into the existing commercial core flood set up (FES350) to track the movement of fluid during water-flooding operation. Besides, it can be considered as the first interaction of radiotracer in the enhanced oil recovery application studies in Malaysia.
Persepsi Perokok Terhadap Implementasi Kawasan Tanpa Rokok (Tinjauan Sistematis)
Authors: Sutrisno Sutrisno , Djannah Sitti Nur
Published: June 2020

ABSTRAK

Rokok menjadi permasalahan yang mengancam kelangsungan hidup generasi di Indonesia. Konsumsi rokokterus meningkat dari tahun ke tahun dan saat ini Indonesia menduduki peringkat ke tiga dunia dengan jumlah perokok tertinggi setelah China dan India. Pemerintah telah membuat berbagai kebijakan strategis yang secara bertahap diharapkan mampu menekan jumlah perokok secara signifikan. Pemberlakuan kawasan tanpa rokok (KTR) merupakan salah satu peta jalan pengendalian dampak konsumsi rokok yang diatur oleh Peraturan Menteri Kesehatan No. 40 tahun 2013. Metode penelitian yang dilakukan adalah systematic review dengan mengambil sumber data pada jurnal portal garuda Ristekdikti yang diunduh pada 2 Januari 2020 sampai dengan 19 Januari 2020. Didapatkan 39 artikel yang sesuai. Setelah dilakukan seleksi dan identifikasi sesuai dengan kriteria inklusi, terdapat 10 artikel yang ditelaah. Hasil penelitian menunjukkan bahwa persepsi perokok terhadap kawasan tanpa rokok cukup baik dan perokok menyetujui pemberlakuan kawasan tanpa rokok. Pemberlakuan kebijakan kawasan tanpa rokok mampu mengendalikan perilaku merokok khususnya di instansi yang memberlakukan kawasan tanpa rokok

Kata kunci : Kawasan Tanpa Rokok, Perilaku Merokok, Bahaya Rokok, Rokok
Antioxidant and hepatoprotective Potential of Coriandrum sativum L. against hepatic injury by Lambda-cyhalothrin insecticide
Authors: DJAHRA Ali Boutlelis , BENKADDOUR Mounia , BENKHERARA Salah , OUAHIBA Bordjiba
Published: June 2020

The objective of this study is to evaluate the antioxidant and hepatoprotective activity of aerial part and seeds of Coriandrum sativum plant against Lambda cyhalothrin insecticide.  Male Wistar Albinos rats were randomly divided into control, LCT, CsA, CsS, CsS+LCT, CsA+LCT groups, after 90 days of treatments Biochemical, some oxidative stress parameters, and histopathology of liver tissue were evaluated. Total polyphenol content in aerial part and the seed extract estimated at 9.29 and 14.64 mg EAG / mg of extract and IC50 for an antioxidant activity equal to 19.38 and 22.62 mg/ml respectively. The obtained results revealed that rats received Lambda cyhalothrin insecticide showed a significant change in enzymes activity (AST, ALT, ALP and c-GT) and Glutathione (GSH) in liver. Meanwhile content of hepatic Malondialdehyde (MDA). Histopathology examination of liver revealed that Coriandrum sativum attenuate the incidence of liver lesions triggered by Lambda cyhalothrin intoxication. Therefore, the results of this study show that Coriandrum sativum can be proposed to protect the liver against Lambda cyhalothrin induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect.

Keywords: hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress.
Refunction Family during Covid-19 Pandemic (Study among Students of Anthropology UGM)
Authors: Abubakar Ali , Ulamy Alya Nabila
Published: June 2020

Today, the family experiences dysfunction because their functions are taken over by the state and the market. Before the Industrial Revolution, most people still relied on their families and communities for food, shelter, education, and employment. New communication and transformation technologies enable markets and governments to pull people out of family security and enter the market as individuals. During the Covid-19 pandemic, the authors saw a tendency for the return of family functions that had been taken away by the state and the market. People are getting closer to their families, especially because of the effects of physical distancing rules by the state. So far there have been no studies that show in detail how a pandemic really influences family functioning. The authors tries to investigate the functions of families returning to work using the daily data of UGM Cultural Anthropology students collected in the Rural Studies class in Indonesia from 30 March 2020 to 29 April 2020. Findings show that family refunction occurred during the pandemic.
Targeted Medical School Admissions: A Strategic Process for Meeting Our Social Mission
Authors: Evans David V. , Jopson Andrew D. , Andrilla C. Holly A. , Longenecker Randall L. , Patterson Davis G.
Published: June 2020

Background and Objectives: Increased medical school class sizes and new medical schools have not addressed the workforce inadequacies in primary care or underserved settings. While there is substantial evidence that student attributes predict practice specialty and location, little is known about how schools use these factors in admissions processes. We sought to describe admissions strategies to recruit students likely to practice in primary care or underserved settings.
Methods: We surveyed admissions personnel at US allopathic and osteopathic medical schools in 2018 about targeted admissions strategies aimed at recruitment and selection of students likely to practice rurally, in urban underserved areas, or in primary care
Results: One hundred thirty-three of 185 (71.8%) US medical schools responded. Respondents reported targeted admissions strategies as follows: rural, 69.2%; urban underserved, 67.4%; and primary care, 45.3%. Nearly 90% reported some type of recruitment outreach to 4-year universities, but much less to community colleges. Student characteristics used to identify those likely to practice in targeted areas were largely evidence-based. Strategies to select students varied widely.
Conclusions: Most responding US medical schools reported a targeted process to recruit and select students likely to practice in rural, urban underserved, or primary care settings, indicating widespread awareness of workforce challenges. This study also demonstrates varying approaches to and allocation of resources toward admissions targeting, especially the application and interviewing processes. Understanding how schools identify and admit students likely to practice in these fields is a first step in identifying best practices for selective admissions focused on addressing workforce gaps.
Ciência, tecnologia e inovação na agenda internacional do Brasil de 1990 a 2010
Authors: Costa Gabriela Dorneles Ferreira da
Published: June 2020

O objetivo do presente trabalho é compreender a presença do tema da Ciência, Tecnologia e Inovação (CTI) na agenda internacional do Brasil no período de 1990 a 2010 à luz das diretrizes de Política Externa Brasileira e das Políticas de Ciência, Tecnologia e Inovação (PCTIs) dos governos abarcados. A hipótese adotada pelo trabalho é a de que se pode notar uma abordagem diferente ao tema da CTI na agenda internacional do Brasil conforme as diferentes orientações político-econômicas dos governos em análise. Os resultados da pesquisa demonstram que à luz das PCTIs a abordagem para a CTI na agenda internacional do Brasil teve continuidade mesmo em governos situados em espectros políticos diferentes. Não obstante, à luz das diretrizes de política externa se observam variações entre os governos da década de 1990 e os governos da década de 2000. Para os anos 2000, foi percebida uma maior atividade internacional brasileira em matéria de CTI na medida em que ocorreram mudanças no perfil internacional do Brasil (com maior proatividade e diversificação de sua atuação) decorrentes de uma nova orientação política-econômica nos anos 2000. Ainda que não seja possível identificar uma priorização do tema da CTI se comparado a outras pautas da agenda internacional do país, o Brasil, de fato, mudou sua atuação internacional em matéria de CTI nos anos 2000.
Brazil and its regional projection: perspectives on hegemony and regionalism in South America in the post-Cold War era
Authors: Ludwig Fernando Jose , Sposito Italo Beltrão
Published: June 2020

A projeção brasileira sobre a América do Sul foi destaque desde sua redemocratização, ocorrida na década de 1980. Ainda assim, seu comportamento não pode ser considerado hegemônico em seu sentido realista, exercido pelo poder duro. Nem liberal, já que optou pela multiplicidade de iniciativas, de baixa grau de institucionalização. Propomos a aplicação do conceito gramsciano de hegemonia para analisar se o Brasil exerce a sua na América do Sul por meio de um ativismo nos processos de integração regional. Para isto, utilizamos o método qualitativo com um estudo de caso único típico para desenvolver uma ilustração preliminar de teoria, baseado em uma revisão bibliográfica da história da política externa Brasileira (fontes primárias e secundárias). Esta análise nos leva a argumentar que há dubiedade na atuação brasileira regional, já que optou por não aprofundar o grau de institucionalização das organizações regionais e por não exercer poder coercitivo durante crises regionais. Ainda que o comportamento brasileiro não representa um caso típico de hegemonia, tendo os achados pouca validade externa para além deste caso, há evidências sua atuação em diversos arranjos regionais como líder e construtor de consensos é uma forma de exercer hegemonia (gramsciana) na região.
Tumors of the orbit as a first manifestation of a lung and breast malignancy
Authors: Stjepanovic Mihailo , Maric Nikola , Baralic Marko , Maric-Zivkovic Jasmina , Mihailovic-Vucinic Violeta
Published: June 2020

Introduction. Orbit is one of the rarer locations for the metastasis of malignant tumors. The symptoms of orbital tumors are nonspecific, but require detail diagnostics. Methods of visualization, such as ultrasound, radiography, computed tomography scan and/or magnetic resonance imaging of the endocranium are a mandatory step in the diagnostics in order to determine not only the spread of the malignancy but also the affliction of the surrounding structures. The orbital manifestations can be the first sign of the malignant disease. Outline of cases. The first case report presents a female patient with ocular symptomatology as a result of a metastasis of previously undiscovered breast cancer, and the second report presents a male patient with undiscovered lung cancer also presenting with ocular symptomatology. Conclusion. An orbital tumor should instigate further diagnostic procedures, as it can be the first sign of a disseminated malignant disease.
Genome-wide association study of mitochondrial DNA in Chinese men identifies seven new susceptibility loci for high-altitude pulmonary oedema
Authors: Tang Caizhi , Yu Chen , Liu Xinyuan , Ran Zhuang , Luo Yongjun
Published: June 2020

Background/Aim. High-altitude pulmonary oedema (HAPE), which normally occurs at altitudes higher than 3,000 m, is a potentially fatal disease due to hypoxia. The role of mitochondrial genomes in determining an individual's susceptibility to HAPE has not been determined yet. However, a number of genetic polymorphisms have recently been found to be overrepresented in HAPE patients. The majority of published genome-wide association studies have investigated only a small number of top-ranking single-nucleotide polymorphisms (SNPs)/genes by the overview of nuclear DNA and considered each of the identified SNPs/genes in-dependently. Little research has been conducted on mitochondrial genomes in relapsing HAPE patients by genome-wide association studies. Methods. To identify biological pathways important to HAPE occurrence, we examined approximately 500,000 SNPs genome-wide from 10 unrelated cases of relapsing HAPE and we compared the SNPs in these cases with those in the Chinese in Beijing, China population (45 controls) to discover the association between genotypes and HAPE susceptibility among the mitochondrial function-related genes. We used the FUMA platform to expand those SNPs to selected candidate SNPs. Results. A total of 369 candidate SNPs, 4 lead SNPs, 4 genomic risk loci and 5 mapped genes were obtained. The 7 mapped genes were ADAMTS9-AS2, NEK1, CLCN3, C4orf27(HPF1), RP11-219J21.2, ANKRD26 and YME1L1. Conclusion. This study confirms the association of ADAMTS9-AS2, NEK1, CLCN3, C4orf27(HPF1), RP11- 219J21.2, ANKRD26 and YME1L1 with HAPE, which may provide future targets for the treatment of this disease.
Prevalence of vitamin D3 deficiency in patients with type 2 diabetes and proteinuria
Authors: Stojsic-Vuksanovic Tatjana , Knezevic Violeta
Published: June 2020

Background/Aim. Vitamin D3 plays an important role in glucose metabolism, with influence on insulin secretion and sensitivity. Low grade inflammation is present in patients with diabetes type 2 and it is a known fact that vitamin D has an anti-inflammatory effect. Vitamin D deficiency is particularly pronounced in patients with diabetic nephropathy. Vitamin D3 levels during the year are associated with seasonal changes primarily influenced by UV radiation. The aim of the study was to examine the prevalence of vitamin D3 deficiency in patients with diabetic nephropathy. Methods. Patients with type 2 diabetes and diabetic nephropathy were included in the study after the vitamin D3 levels were established. The results were classified according to a lower limit level given for each month being reduced or normal values. For the purpose of further research, patients with low vitamin D3 levels were divided into two groups, study and control group, each including 45 patients. The study group received cholecalciferol at the dose necessary to achieve the intended optimal vitamin D3 blood level of 90?100 nmol/L. Results. At the beginning of the study, vitamin D3 value for all patients with vitamin D3 deficiency (n = 90) was 45.1 ? 15.6 nmol /L. Vitamin D3 deficiency in the study sample (n = 109) was found in 82.56% of participants, while the normal values of vitamin D 3 were found in 1 7.43% of patients. There is a statistically significant difference in the deviation of vitamin D3 levels from the lower normal values in the whole group of subjects between winter and summer, with the deviation being more pronounced in summer. There is no gender difference in these values, although in both men and women there is a more pronounced deviation in summer. Conclusion. Vitamin D3 deficiency is significantly represented in patients with type 2 diabetes and diabetic nephropathy.
Privacy-Preserving Information Sharing within an Audit Firm
Authors: Kogan Alexander , Yin Cheng
Published: June 2020

This paper explores the possibility of sharing contemporaneous firm-level information within an audit firm in a privacy-preserving manner. We develop a number of sharing schemes for utilizing contemporaneous accounting information from peer companies without violating clients' confidentiality and observe significant improvements in both estimation accuracy and error detection performance. To satisfy different levels of privacy protection, we propose different sharing schemes by utilizing auditors' self-generated expectations, and the results show that the benefits to auditors from only sharing self-generated estimation residuals (errors) are comparable to that from sharing predicted or actual accounting numbers. To satisfy stricter privacy concerns, we also propose a series of schemes based on sharing categorical information derived from prediction errors. Finally, we use Borda counts to analyze how the choice of the best model changes depending on the cost of errors within different experimental settings.
CEO Employment Contract Horizon and Financial Reporting Discretion
Authors: Gong Guojin , Wang Juan , Lee Hyun Jung (JoAnn)
Published: June 2020

We examine the effect of employment contract horizon on managers' discretion in financial reporting. During the contract horizon, the board learns about a new CEO's ability from realized firm performance and uses this information to determine whether to renew or terminate the CEO's contract. Economic theory suggests that the informational value of firm performance to the board's learning declines over time as the board's estimate of the CEO's ability becomes more precise; this motivates a CEO to overstate earnings more aggressively during the earlier stage of the contract horizon. Consistently, we find more (less) aggressive earnings overstatement during the earlier (later) stage of the first contract horizon. This finding is stronger for CEOs who have greater concerns over contract termination and CEOs who have greater flexibility to manipulate earnings. Our evidence suggests that the CEO employment contract horizon has a significant impact on managerial discretion in financial reporting.

JEL Classification: G34; J41; M40; M41.
Understanding the Determinants of Analyst Target Price Implied Returns
Authors: Dechow Patricia M. , You Haifeng
Published: June 2020

We investigate the determinants of analysts' target price implied returns and the implication of our findings for investment decision-making. We identify four broad sets of factors that help explain the cross-sectional variation in target price implied returns: future realized stock returns, errors in forecasting fundamentals, errors in forecasting the expected return to risk, and biases relating to analysts' incentives. Our results suggest that all four sets help explain target price implied returns, with errors in forecasting the expected return to empirical risk proxies having the greatest impact. Collectively, these variables explain nearly a quarter of the cross-sectional variation in target price implied returns. We use our model to predict the optimistic bias in target price implied returns and evaluate whether investors correctly ignore the predictable bias. The results suggest that investors make similar valuation errors to analysts and/or do not perfectly back out the predicted bias in target prices.

JEL Classifications: M40; M41; G14.
CIDADANIA E ESCOLA NO CONTEXTO DIGITAL
Authors: Ponte Cristina
Published: June 2020

Na primeira parte, o artigo analisa dimensões da cidadania que influenciaram a configuração da escola como local de aprendizado social e confronta esses enquadramentos com resultados de estudos EU Kids Online (Portugal) e TIC Kids Online (Brasil) sobre oportunidades digitais e atividades online reportadas por crianças e adolescentes. Na segunda parte, o artigo confronta as políticas educacionais sobre cidadania em Portugal com as respostas dos jovens estudantes portugueses sobre a formação escolar que receberam no último ano em cidadania digital. As conclusões apontam para a relevância das escolas como instituições sociais que não devem nem bloquear as oportunidades oferecidas pelo digital nem ignorar os seus riscos para uma cidadania plena.
A CULTURA DA ESCOLA RECONTEXTUALIZANDO A INTEGRAÇÃO DAS TDIC NO CURRÍCULO
Authors: Loio Milene Peixer , Espíndola Marina Bazzo de , Cerny Roseli Zen , Müller Tosatti Nayara Cristine
Published: June 2020

O contexto escolar é constantemente pressionado pelas demandas sociais, delimitado pelas políticas e pelas percepções sociais acerca da função da escola na sociedade atual. Dentre as principais demandas, a integração de tecnologias nas práticas e nos currículos aparecem com grande ênfase nas políticas e nas discussões. No entanto, é no chão da escola, que as expectativas e as próprias Tecnologias Digitais de Informação e Comunicação (TDIC) são reconfiguradas e recontextualizadas. Este artigo é um recorte de uma pesquisa maior e nele temos por objetivo, analisar como os professores ressignificam as possibilidades das TDIC no currículo a partir da cultura da escola. A partir das falas de professores e gestores de quatro escolas públicas do estado de Santa Catarina, emergiram as seguintes categorias de análise: (i) Infraestrutura local e seus impactos na integração de TDIC ao currículo da escola; (ii) Políticas da gestão da escola para a integração das TDIC; (iii) Experiências do coletivo da escola com integração de TDIC; (iv) Potencialidades pedagógicas das TDIC vislumbradas pelo coletivo da escola para seu contexto. As diferenças significativas que cada escola apresentou em seus contextos, especialmente na relação da gestão de infraestrutura, refletem em como elas ressignificam o uso das TDIC e as integram ao currículo.
OS CONTEÚDOS NO CURRÍCULO CULTURAL DA EDUCAÇÃO FÍSICA E A VALORIZAÇÃO DAS DIFERENÇAS: ANÁLISES DA PRÁTICA PEDAGÓGICA
Authors: Neira Marcos Garcia
Published: June 2020

O artigo descreve uma pesquisa que objetivou investigar quais são os conteúdos abordados no currículo cultural da Educação Física e o modo como isso acontece. Para tanto, submeteu à análise cultural os relatos de experiência produzidos por professores e professoras que afirmam inspirar-se na proposta. Os resultados evidenciam um rompimento com a visão tradicional do conhecimento e das atividades de ensino. Constatou-se que os conteúdos compreendem os discursos verbais e não verbais alusivos às práticas corporais, independentemente da fonte, acessados mediante situações didáticas diversificadas. Devido ao comprometimento ético-político da proposta, as situações didáticas problematizam as narrativas hegemônicas e desconstroem as representações pejorativas sobre as manifestações culturais corporais dos grupos minoritários. Consequentemente, valoriza o direito às diferenças com o recurso da etnografia, historiografia e arquegenealogia das brincadeiras, danças, lutas ou esportes tematizados nas aulas.
PROCESSOS AVALIATIVOS EM MATEMÁTICA: UM ESTUDO SOBRE AVALIAÇÕES EDUCACIONAIS
Authors: Ribeiro Vera Mônica , Costa Nielce Meneguelo Lobo da
Published: June 2020

Este artigo provém de uma pesquisa de mestrado em Educação Matemática sobre um processo de formação continuada docente que teve como objeto de estudo a Avaliação da Aprendizagem em Processo – AAP, que é aplicada nas escolas estaduais paulistas. A metodologia da investigação foi a qualitativa, do tipo pesquisa-ação, conforme Thiollent. A investigação foi composta por: pesquisa documental; elaboração do processo formativo e dos instrumentos de coleta de dados e de pesquisa em campo. Neste artigo o cerne é a pesquisa documental, com um breve histórico da avaliação educacional e discussão sobre a AAP. O aporte teórico veio de estudos de Haydt, Luckesi, Hoffmann, Libâneo e Buriasco sobre avaliação. Foi realizada pesquisa nos documentos oficiais que normatizam e orientam a prática avaliativa do professor da Educação Básica, relativas à Matemática, principalmente para a Avaliação da Aprendizagem em Processo. Os resultados da pesquisa documental forneceram subsídios para compreensão sobre a proposta da AAP, sobre como ocorreu sua implantação, assim como a permanência e evolução até a presente data, além do entendimento sobre sua importância para avaliar a aprendizagem da Matemática nas escolas estaduais paulistas.
Lugar geométrico de curvas: construções e demonstrações das cônicas usando o GeoGebra
Geometrical place of curves: constructions and demonstrations of conics using GeoGebra
Authors: Cavalcante Jefferson Felipe Albuquerque , Melo Vanio Fragoso de , Santos Viviane De Oliveira
Published: June 2020

A utilização de recursos didáticos demanda o desenvolvimento de diversos métodos de ensino. Com o objetivo de enfrentar os desafios impostos pela tecnologia para auxiliar nas aulas, uma das possibilidades é o uso do GeoGebra. Dessa forma, com o auxílio desse software, apresentaremos diferentes maneiras de construir as cônicas usando circunferências, retas, semirretas, segmentos de reta e pontos. Para mostrar que os lugares geométricos criados são cônicas, realizaremos as demonstrações de forma algébrica e/ou geométrica, deixando-as mais práticas e de fácil visualização com o suporte do programa, prontas para serem aplicadas em sala, como o docente preferir. Nosso intuito é iniciar o estudante no método investigativo da matemática usando demonstrações, com a finalidade de desenvolver o seu raciocínio lógico-matemático.
ASEAN COMISSION ON PROMOTION AND PROTECTION OF RIGHTS OF WOMEN AND CHILDREN ( ACWC ) POLICIES IN ME VIOLENCE RESPONSE TO WOMEN IN THE SPIRIT
Authors: Afriantari Rini , Budiana M
Published: June 2020

The conflict in Rohingnya is not a new thing for countries in the Southeast Asia region, this conflict has been going on for along time and is one form of gross human rights violatins. Many of the Rohingnya people who accept physical and psychological violence are no exception for women, women in the Rohingnya not only accept ordinary physical violence but also accept sexual violence as well. This study aims to explain why ACWC seems helpless in dealing with violence against women that occurs in the Rohingnya.
Long-term effect of farming systems on the yield of crop rotation and soil nutrient content
Authors: KERES INDREK , Alaru Maarika , Eremeev Viacheslav , Talgre Liina , Luik Anne , Loit Evelin
Published: June 2020

The effects of organic (manure, cover crop) and mineral fertilisers on total yield, soil phosphorus (P) and potassium (K) dynamics and soil pH changes were studied over 10 years. Five field crops (spring barley, red clover, winter wheat, field pea, potato) were grown organically and conventionally in rotation. The total yield of the five crops fertilized similarly was 24–25% higher in conventionally fertilised treatments than in organic treatments. The higher yielding conventionally fertilised treatments (annual total yield 29.0–29.8 t ha–1) removed 12–18 kg ha–1 P and 45–73 kg ha–1 K per year, which was respectively 28–35% and 28–40% higher than organic treatments. The soil became more acidic in the conventional system (pH 5.4–5.9 versus 5.9–6.3). The highest annual P and K uptake was by potato, followed by winter wheat. Use of winter cover crops and composted cattle manure in the organic system did not maintain the levels of P and K in the soil at baseline.
Pengaruh Iklan Televisi dan Word of Mouth (WOM) terhadap Minat Beli Smartphone Mito pada Mahasiswa Universitas Negeri Padang
Authors: Septrizola Whyosi , Rahmiati Rahmiati , Asria Maya
Published: June 2020

This research aims to analyze the effects of Television Advertising AndWord of Mouth (WOM) Toward Purchase Intention MiTO Smartphone on Padang State University’s Students. Populations in the research are theall students of students at Padang State University as much as 7.185 persons.Sampling has been developed throughthe accidentall sampling with Cochran, resulting in 300 respondents. The data have been collected by main instrument of questionnaire. Technical data analysis with multiple linear regression and using t-test. The results of research indicate that television advertising and Word of Mouth (WOM) has a significan efect Toward Purchase Intention MiTO Smartphone on Padang State University’s Students.
Identifikasi pengaruh perceived organizational support terhadap kepuasan kerja dengan work engagement sebagai variabel pemediasi
Authors: Sarianti Rini , Fitria Yuki , Nazara Etha Visari
Published: June 2020

The purpose of this research is to analyze (1) the influence of perceived organizational support on job satisfaction (2) the influence of perceived organizational support on employee engagement (3) the influence of perceived organizational support on job satisfaction with employee engagement as a mediating variable. The population in this research are the employees of Department of PT. West Sumatera Regional Development Bank of Padang consist of 115 employees. The samples were selected using Clustered Proportional Random Sampling which the total of the samples are 89 employees. The data used are primary data and secondary data. The data was analyzed using multiple regression analysis with mediating variable. The result of this research shows (1) perceived organizational support has a positive and significant relationship on job satisfaction (2) perceived organizational support has a positive and significant relationship on employee engagement (3) employee engagement become a mediator on the effect of perceived organizational support on job satisfaction.Keywords: Perceived organizational support; job satisfaction; employee engagement.
Pengaruh dimensi kualitas jasa terhadap minat mengunjungi kembali wisatawan pada objek wisata pantai carocok Painan
Authors: Karim Haniful , Abror Abror
Published: June 2020

This research aims to examine the relationship between service quality dimensions and revisit intention. The population of this study is tourists who visited “Carocok Painan Beach”. This research employed 100 respondents as the samples. By using linear regression analysis, this study found that all service quality dimensions, including tangible, responsiveness, reliability, assurance and empathy have significant and positive impacts on tourist’s revisit intention. Furthermore, some limitations and future studies have been addressed.Keywords: Tangibles; responsiveness; reliability; assurance; empathy; revisit intention
Pengaruh desain produk dan harga terhadap minat beli konsumen mebel jati jepara pada Toko Usaha Baru Furniture di Lubuk Alung
Authors: Sutiyem Sutiyem , Ravelby Thesa Alif , Trismiyanti Dessy
Published: June 2020

This study aims to determine the effect of product design and price on consumer interest in buying Jepara Teak furniture at the New Furniture Business Shop in Lubuk Alung. This type of research is associative quantitative research, the number of research samples were 100 people. Data was collected in the form of questionnaires and using analyzed SPSS software ver.21.0 for Windows. The conclusions from this study is the product design variable (X1) has a significant positive effect on purchase decision in Jati Jepara furniture at the New Furniture Business Shop in Lubuk Alung, as evidenced by t value > t table (10,400> 1,660) and a significant influence between price variables ( X2) purchase decision with t value> t table (2,015> 1,660). There is a positive and significant influence between product design (X1) price (X2), on purchase decision of Jati Jepara furniture consumers with an F-value 156,644> F- table (3,09) means that it affects together. The coefficient of determination (R²) results obtained a coefficient of 0.764 or 76.4%, while 23.6% is influenced by other variables.Keywords: Product design; prices; purchase decision.
Meningkatkan pemahaman mahasiswa terhadap manajemen pemasaran melalui metode pembelajaran peta konsep (mind mapping)
Authors: Azhari Devi Syukri
Published: June 2020

This research aims to improve the quality of Marketing Management learning, to enhance student enthusiasm for learning, to improve lecturers' skills in developing learning models and media, and to improve student learning achievement. The results showed that students' learning achievements experienced an increase in each cycle. Mastery of student learning before applying the concept map method 0%, after applying the concept map method, mastery learning from students after the final test is 9 4%. Interest, activeness, and collaboration of students in the learning process with a range of 1-4 results are good (3.44). The results of observations on the skills of lecturers in the management of learning using the concept map method with a range of 1-4 show good results with the mean of cycle 1, cycle 2, and cycle 3, 38. The score is the average of all aspects observed in three cycles.Keywords:Marketing management; mind mapping learning method.