bluuebunny/crossref_metadata_2025 huggingface dataset:
The path to UHC: The Lessons learnt from transitioning from a Community-based to a State-wide health insurance Scheme in Nigeria.
Authors: Bolarinwa Oladimeji Akeem , Akande Tanimola Makanjuola , Janssens Wendy , Boahene Kwasi , Wit Tobias Rinke de
Published: January 2020

Background Social health insurance has been widely proposed as a key strategy in moving towards universal health coverage. This paper reports on the transition of a community-based health insurance scheme in Kwara State, Nigeria, in 2016 to a state-wide social insurance program. Specifically, it analyses the consequences of the temporary suspension of the community-based insurance scheme during the transition period on healthcare utilization and financial protection.Methods A mixed methods study was carried out in 2018 using a semi-quantitative cross-sectional survey amongst 600 clients, in-depth interviews with 24 clients and 29 participating public and private healthcare providers.Results Most former enrollees (95.3%) kept using Kwara Community Health Insurance Program (KCHIP) facilities, even after the suspension of the program. Over 70% of respondents reverted to out-of-pocket (OOP) payment for healthcare services and 67% experienced constraints in payment for healthcare services after suspension of the program. Most common coping mechanisms for healthcare payment was personal savings (63.3%). Seventeen of 29 facilities recorded a decrease in revenue after suspension of the program. Being male (OR=1.61), respondents living in rural communities (OR=1.77), those who use KCHIP exclusively (OR=1.94) and acutely ill respondents (OR=3.38) had increased odds of being constrained with the suspension of the program.Conclusion After suspension of the KCHIP, many enrollees and health facilities experienced constraints. Enrollees’ most important coping mechanisms remained personal savings which has more likelihood of pushing them to catastrophic expenditure.
Albendazole regulates radiosensitivity of human pancreatic cancer cells by inhibiting HIF-1α and basic fibroblast growth factor
Authors: Chen Haifeng , Zhou Xiaochong , Weng Zhen , Wei Xing , Xu Chunfang , He Yang
Published: January 2020

Background Albendazole, a clinical antiparasitic drug, has been shown to have antitumor activity and supress expression of hypoxia-inducible factor 1-alpha. While hypoxia, the most prominent feature of tumor microenvironment, is associated with radiotherapy tolerance. Herein, we aimed to identify Albendazole as a candidates that improves tumor microenvironment and enhances the radiosensitivity of human pancreatic cancer cells. Methods MTT assay, clone formation and flow cytometry were performed to assess the effect of ABZ and radiation on PC cell line proliferation and apoptosis induction. In addition, the expression levels of hypoxia-inducible factor 1-alpha (HIF-1α) and basic fibroblast growth factor (bFGF) were assessed using western blotting. Finally, the effects of ABZ on tumor growth and radiosensitivity were examined using nude mice xenograft model. Results ABZ significantly improved hypoxia-induced radiation resistance in PC cell line PATU8988 and SW1990 as evidenced by decreased absorbance of MTT, reduced colony number, and increased apoptotic cell ratio. Furthermore, the in vivo results confirmed that ABZ suppressed tumor growth. On mechanisms, treatment with ABZ decreased HIF-1α and bFGF expression levels, which correlated with radioresistance in cells exposed to hypoxia in vitro and tumor to radiation in vivo. Conclusion Taken together, our datas show that HIF-1α and bFGF regulate radiation sensitivity in PC cells under hypoxic conditions. And ABZ enhances radiosensitivity of pancreatic cancer by suppression of HIF-1α and bFGF expression.
Isoform-Selective PI3K Inhibitors for Various Diseases
Authors: Bheemanaboina Rammohan R.Y.
Published: January 2020

Phosphoinositide 3-kinases (PI3Ks) are a family of ubiquitously distributed lipid kinases that control a wide variety of intracellular signaling pathways. Over the years, PI3K has emerged as an attractive target for the development of novel pharmaceuticals to treat cancer and various other diseases. In the last five years, four of the PI3K inhibitors viz. Idelalisib, Copanlisib, Duvelisib, and Alpelisib were approved by the FDA for the treatment of different types of cancer and several other PI3K inhibitors are currently under active clinical development. So far clinical candidates are non-selective kinase inhibitors with various off-target liabilities due to cross-reactivities. Hence, there is a need for the discovery of isoform-selective inhibitors with improved efficacy and fewer side-effects. The development of isoform-selective inhibitors is essential to reveal the unique functions of each isoform and its corresponding therapeutic potential. Although the clinical effect and relative benefit of pan and isoformselective inhibition will ultimately be determined, with the development of drug resistance and the demand for next-generation inhibitors, it will continue to be of great significance to understand the potential mechanism of isoform-selectivity. Because of the important role of type I PI3K family members in various pathophysiological processes, isoform-selective PI3K inhibitors may ultimately have considerable efficacy in a wide range of human diseases. This review summarizes the progress of isoformselective PI3K inhibitors in preclinical and early clinical studies for anticancer and other various diseases.
Telomere-related Markers for Cancer
Authors: Yuan Xiaotian , Dai Mingkai , Xu Dawei
Published: January 2020

Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and
essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively
with each round of cell divisions, which serves as an important barrier to uncontrolled proliferation
and malignant transformation. In sharp contrast, telomere maintenance is a key feature of human
malignant cells and required for their infinite proliferation and maintenance of other cancer hallmarks
as well. Thus, a telomere-based anti-cancer strategy has long been suggested. However, clinically efficient
and specific drugs targeting cancer telomere-maintenance have still been in their infancy thus far.
To achieve this goal, it is highly necessary to elucidate how exactly cancer cells maintain functional
telomeres. In the last two decades, numerous studies have provided profound mechanistic insights, and
the identified mechanisms include the aberrant activation of telomerase or the alternative lengthening of
telomere pathway responsible for telomere elongation, dysregulation and mutation of telomereassociated
factors, and other telomere homeostasis-related signaling nodes. In the present review, these
various strategies employed by malignant cells to regulate their telomere length, structure and function
have been summarized, and potential implications of these findings in the rational development of telomere-
based cancer therapy and other clinical applications for precision oncology have been discussed.
Underlying Mechanisms and Potential Therapeutic Molecular Targets in Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage
Authors: Li Yuchen , Wu Pei , Bihl Ji C. , Shi Huaizhang
Published: January 2020

Aneurysmal subarachnoid hemorrhage (aSAH) is a subtype of hemorrhagic stroke with
significant morbidity and mortality. Aneurysmal bleeding causes elevated intracranial pressure,
decreased cerebral blood flow, global cerebral ischemia, brain edema, blood component extravasation,
and accumulation of breakdown products. These post-SAH injuries can disrupt the integrity
and function of the blood-brain barrier (BBB), and brain tissues are directly exposed to the neurotoxic
blood contents and immune cells, which leads to secondary brain injuries including inflammation
and oxidative stress, and other cascades. Though the exact mechanisms are not fully clarified,
multiple interconnected and/or independent signaling pathways have been reported to be involved
in BBB disruption after SAH. In addition, alleviation of BBB disruption through various pathways
or chemicals has a neuroprotective effect on SAH. Hence, BBB permeability plays an important
role in the pathological course and outcomes of SAH. This review discusses the recent understandings
of the underlying mechanisms and potential therapeutic targets in BBB disruption after SAH,
emphasizing the dysfunction of tight junctions and endothelial cells in the development of BBB
disruption. The emerging molecular targets, including toll-like receptor 4, netrin-1, lipocalin-2,
tropomyosin-related kinase receptor B, and receptor tyrosine kinase ErbB4, are also summarized in
detail. Finally, we discussed the emerging treatments for BBB disruption after SAH and put forward
our perspectives on future research.
Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways
Authors: Rebas Elzbieta , Rzajew Jowita , Radzik Tomasz , Zylinska Ludmila
Published: January 2020

Background:

Balance in neurotransmission is essential for the proper functioning of the
nervous system and even a small, but prolonged disturbance, can induce the negative feedback
mechanisms leading to various neuropathologies. Neurodegenerative and mood disorders such as
Alzheimer’s, Parkinson’s or affective disorders are increasing medical and social problems. Among
the wide spectrum of potentially destructive events, oxidative stress and disrupted metabolism of
some neurotransmitters such as acetylcholine, GABA, glutamate, serotonin or dopamine appear to
play a decisive role. Biologically active plant polyphenols have been shown to exert a positive impact
on the function of the central nervous system by modulation of metabolism and the action of
some neurotransmitters.

Methods:

Based on published research, the pharmacological activities of some naturally occurring
polyphenols have been reviewed, with a focus on their potential therapeutic importance in the regulation
of neurotransmitter systems.

Results:

Phytochemicals can be classified into several groups and most of them possess anticancer,
antioxidative, anti-inflammatory and neuroprotective properties. They can also modulate the metabolism
or action of some neurotransmitters and/or their receptors. Based on these properties, phytochemicals
have been used in traditional medicine for ages, although it was focused mainly on
treating symptoms. However, growing evidence indicates that polyphenols may also prevent or
slow neurological diseases.

Conclusion:

Phytochemicals seem to be less toxic than synthetic drugs and they can be a safer alternative
for currently used preparations, which exert adverse side effects. The neuroprotective actions
of some plant polyphenols in the regulation of neurotransmitters metabolism, functioning of
neurotransmitters receptors and antioxidative defense have potential therapeutic applications in
various neurodegenerative disorders.
Combination of ZnO Nanoparticle with Marine Sponge Derived Dipeptide for Enhanced Anticancer Efficacy in Liver Cancer Cells and their Toxicity Evaluation on Embryonic Zebrafish
Authors: Karanam Gayathri , Kumar Arumugam Madan , Yerukalapudi Chinmai Sriamulya , Natesh Nagabhishek Sirpu , Boddula Rajender , Pothu Ramyakrishna
Published: January 2020

Background:

Nanomaterials-based cancer therapy plays a significant role in increasing
the therapeutic efficiency of anticancer drugs, reducing side effects and targeted delivery of the drug
payloads. The present study was aimed to enhance the anticancer effect of a novel dipeptide isolated
from marine sponge-associated Bacillus pumilus AMK1 by formulating with Zinc oxide (ZnO) nanoparticles
for the effective treatment against HepG2 liver cancer cells.

Methods:

ZnO nanoparticles were synthesized by chemical method and size of the nanoparticle was
characterized by Scanning electron microscope, X-Ray diffraction and Fourier-transform infrared
spectroscopy. Furthermore, ZnO nanoparticles were conjugated with the isolated dipeptide and evaluated
for anticancer activity. In addition, distinct morphological changes were observed by performing
apoptotic staining methods such as propidium iodide staining and acridine orange/ ethidium bromide
staining. Furthermore, embryotoxic and teratogenic effects of conjugated dipeptide on the development
of zebrafish embryo were investigated in this study.

Results:

It was observed that conjugated dipeptide showed enhanced cytotoxicity against HepG2 liver
cancer cells without any toxic effect on normal liver cells. ZnO with dipeptide showed significant
higher apoptosis of liver cancer cells, with around 19% in early apoptosis and 53% in late apoptosis
stage. The obtained results suggest that ZnO nanoparticle conjugated dipeptide initiated cytotoxicity
through apoptotic death in HepG2 cells. The embryotoxic studies in zebrafish embryos revealed the
LC50 197.0 μg/mL. These findings suggest that conjugated dipeptide affected the development of
zebrafish embryos only at relatively higher concentrations.

Conclusion:

The experimental results demonstrate that ZnO nanoparticle conjugated dipeptide has
the potential to improve anticancer efficacy against liver cancer cells by inducing apoptosis in cancer
cells without any effect on normal liver cells.
SUSTAINABLE UTILIZATION OF FLAX FIBER POLYMER COMPOSITES: A REVIEW.
Authors: Arunprasath K. , Arumugaprabu V. , Amuthakkannan P. , Manikandan V.
Published: January 2020

:

The application of flax fiber is vast in the various fields as textiles made from flax are known in the Western countries as linen, and traditionally used for bed sheets, underclothes, and table linen. The specific properties that are responsible for the potential platform to next-generation structural applications in automobile and other consumer works. Due to its mechanical properties, which elaborately specify the single flax, hybridization of fiber with the manmade and with natural flax. Ultimately, in the end of the paper, we discussed with the proportion evaluation to know about the amount of research undergone with flax fiber. To identify the further quantum of work to be done in the all of the areas in that 36% of work done on mechanical property, 30% in novel performance work like simulation and model analysis, 18% of work going on marine, aeronautical related applications and only 16% work carried out in structural related applications. From the literature study, the usage of flax fiber has lankness in a variety of applications in various fields. In the future, the flax fiber will reduce the utilization of synthetic fiber, by producing an eco-friendly environment in all type of products wherever replacement is possible.
ВПЛИВ ІНСУЛІНОРЕЗИСТЕНТНОСТІ НА ТИРЕОЇДНИЙ ГОМЕОСТАЗ ЩУРІВ ЗА УМОВ ВРОДЖЕНОГО ТА НАБУТОГО ЙОДОДЕФІЦИТУ
Authors: Стецев'ят В. Б. , Воронич-Семченко Н. М.
Published: January 2020

Резюме. Зважаючи на поширеність цукрового діабету, високий ризик розвитку йододефіцитних захворювань в Україні, особливо в ендемічних регіонах, представляє інтерес з’ясування тиреоїдного профілю за умов інсулінорезистентності. Такі дані дозволять розширити профілактичні заходи та діагностику мінімальної тиреоїдної недостатності. Мета дослідження – дослідити вплив інсулінорезистентності на тиреоїдний гомеостаз щурів за умов вродженого та набутого йододефіциту з урахування статевого диморфізму.

У результаті дослідження у сироватці крові інсулінорезистентних тварин виявили зменшення вмісту тиреотропного гормону аденогіпофіза – ТТГ (достовірними були тільки зміни у самок – на 43 %, p1-2 <0,05), вільного трийодтироніну (fТ3) – у самців та самок на 36 та 39% (p1-2 <0,05) відповідно, тоді як рівень вільного тироксину (fТ4) достовірно не відрізнявся від контролю. Така динаміка зумовила суттєве зниження індекса ТТГ/fТ4 (більше у самок) щодо вихідних даних. Підтверджено, що інсулінорезистентність порушує механізми гіпоталамо-гіпофізарної регуляції, що супроводжується змінами компенсаторної реакції щитоподібної залози на вплив струмогенів. Тому маркерами для діагностики порушень тиреоїдного гомеостазу за умов інсулінорезистентності є зниження індексів ТТГ/fТ4, fТ3/fТ4. Йододефіцит супроводжується переважною секрецією fТ3 на тлі гіпертиреотропії, що зумовлює зростання ТТГ/fТ4, а також індекса периферичної конверсії fТ3/fТ4. Таким чином, встановлено, що інсулінорезистентність є фактором ризику розвитку гіпотиреоїдної дисфункції. Більш небезпечним є розвиток інсулінорезистентності на тлі йододефіциту (особливо за умов вродженої йодної депривації). Ймовірність формування тиреоїдної дисфункції вища у статевозрілих самок.
Educar para el cambio y la sostenibilidad: Evaluación de una propuesta de aprendizaje experiencial para formar al profesorado en formación inicial
Authors: Varela-Losada Mercedes , Arias-Correa Azucena , Marcote Pedro Vega
Published: January 2020

Uno de los principales retos que debe afrontar la educación es la búsqueda de la Sostenibilidad. Y en este proceso, el profesorado es un pilar fundamental. Por ello, se presenta una propuesta educativa de formación inicial de profesorado basada en la experimentación y análisis de un ciclo de aprendizaje entorno a la problemática socioambiental del cambio climático. Para su evaluación se utilizó una metodología de carácter mixto. Los resultados obtenidos sugieren que este tipo de prácticas pueden contribuir a mejorar el compromiso del futuro profesorado con una Educación Ambiental orientada hacia la Sostenibilidad y crítica con el modelo actual de desarrollo, permitiendo la construcción de un marco educativo basado en metodologías globalizadas y participativas, así como a favorecer la adquisición de competencias docentes.
The effectiveness of a web-based psycho-education program in a community in Selangor, Malaysia: A randomized controlled trial (Preprint)
Authors: Mohd-Sidik Sherina , Kader Maideen Siti Fatimah , Rampal Lekhraj , Mukhtar Firdaus
Published: January 2020

BACKGROUND

Background
Mental health problems namely depression and anxiety are the most common problems in the community. Often patients do not seek professional care due to the stigma attached to it.

OBJECTIVE

The study aimed to determine the effectiveness of a web-based psycho-education program in managing mild depression and anxiety.
Methods

METHODS

A two-arm randomized controlled trial of a single blinded, parallel study comparing a four weeks of web-based psycho-education intervention program versus a wait list control group was carried out. The intervention program consisted of four sessions, with each session accessed on a weekly basis. Participants aged 18 years and above, who have participated in the first phase of this study, having access to internet and who are internet literate were invited to participate in the study. By using a random number table, 119 eligible and consented participants were randomly assigned to either the intervention or the control group using random number table. The primary outcomes were depression and anxiety score while the secondary outcome was mental health literacy score, which were all assessed at baseline, week 5 and week 12. Analysis was based on intention to treat analysis.

RESULTS

Significant difference in the mental health literacy score between the intervention and the control group was observed, F (1,117) = 20.149, p<0.001, n2=0.142. No significant difference was found in the depression (p= 0.361) and anxiety scores (p= 0.797).

CONCLUSIONS

The psycho-education intervention was effective in increasing the mental health literacy of the participants.

CLINICALTRIAL

The trial is registered in International Standard Randomized Controlled Trial, ISRCTN 39656144.
Understanding Gaps Between Daily Living and Clinical Settings in Chronic Disease Management: Qualitative Study (Preprint)
Authors: Ozkaynak Mustafa , Valdez Rupa , Hannah Katia , Woodhouse Gina , Klem Patrick
Published: January 2020

BACKGROUND

Management of chronic conditions entails numerous activities in both clinical and daily living settings. Activities across these settings interact, creating a high potential for a gap to occur if there is an inconsistency or disconnect between controlled clinical settings and complex daily living environments.

OBJECTIVE

The aim of this study is to characterize gaps (from the patient’s perspective) between health-related activities across home-based and clinical settings using anticoagulation treatment as an example. The causes, consequences, and mitigation strategies (reported by patients) were identified to understand these gaps. We conceptualized gaps as latent phenomena (ie, a break in continuity).

METHODS

Patients (n=39) and providers (n=4) from the anticoagulation clinic of an urban, western mountain health care system were recruited. Data were collected through primary interviews with patients, patient journaling with tablet computers, exit interviews with patients, and provider interviews. Data were analyzed qualitatively using a theory-driven approach and framework method of analysis.

RESULTS

The causes of gaps included clinician recommendations not fitting into patients’ daily routines, recommendations not fitting into patients’ living contexts, and information not transferred across settings. The consequences of these gaps included increased cognitive and physical workload on the patient, poor patient satisfaction, and compromised adherence to the therapy plan. We identified resources and strategies used to overcome these consequences as patient-generated strategies, routines, collaborative management, social environment, and tools and technologies.

CONCLUSIONS

Understanding gaps, their consequences, and mitigating strategies can lead to the development of interventions that help narrow these gaps. Such interventions could take the form of collaborative health information technologies, novel patient and clinician education initiatives, and programs that strongly integrate health systems and community resources. Current technologies are insufficient to narrow the gaps between clinical and daily living settings due to the limited number and types of routines that are tracked.
Clinical Desire for an Artificial Intelligence–Based Surgical Assistant System: Electronic Survey–Based Study (Preprint)
Authors: Park Soo Jin , Lee Eun Ji , Kim Se Ik , Kong Seong-Ho , Jeong Chang Wook , Kim Hee Seung
Published: January 2020

BACKGROUND

Techniques utilizing artificial intelligence (AI) are rapidly growing in medical research and development, especially in the operating room. However, the application of AI in the operating room has been limited to small tasks or software, such as clinical decision systems. It still largely depends on human resources and technology involving the surgeons’ hands. Therefore, we conceptualized AI-based solo surgery (AISS) defined as laparoscopic surgery conducted by only one surgeon with support from an AI-based surgical assistant system, and we performed an electronic survey on the clinical desire for such a system.

OBJECTIVE

This study aimed to evaluate the experiences of surgeons who have performed laparoscopic surgery, the limitations of conventional laparoscopic surgical systems, and the desire for an AI-based surgical assistant system for AISS.

METHODS

We performed an online survey for gynecologists, urologists, and general surgeons from June to August 2017. The questionnaire consisted of six items about experience, two about limitations, and five about the clinical desire for an AI-based surgical assistant system for AISS.

RESULTS

A total of 508 surgeons who have performed laparoscopic surgery responded to the survey. Most of the surgeons needed two or more assistants during laparoscopic surgery, and the rate was higher among gynecologists (251/278, 90.3%) than among general surgeons (123/173, 71.1%) and urologists (35/57, 61.4%). The majority of responders answered that the skillfulness of surgical assistants was “very important” or “important.” The most uncomfortable aspect of laparoscopic surgery was unskilled movement of the camera (431/508, 84.8%) and instruments (303/508, 59.6%). About 40% (199/508, 39.1%) of responders answered that the AI-based surgical assistant system could substitute 41%-60% of the current workforce, and 83.3% (423/508) showed willingness to buy the system. Furthermore, the most reasonable price was US $30,000-50,000.

CONCLUSIONS

Surgeons who perform laparoscopic surgery may feel discomfort with the conventional laparoscopic surgical system in terms of assistant skillfulness, and they may think that the skillfulness of surgical assistants is essential. They desire to alleviate present inconveniences with the conventional laparoscopic surgical system and to perform a safe and comfortable operation by using an AI-based surgical assistant system for AISS.
Exploring the Use of Mobile Health to Improve Community-Based Health and Nutrition Service Utilization in the Hills of Nepal: Qualitative Study (Preprint)
Authors: Acharya Ajay , Cunningham Kenda , Manandhar Shraddha , Shrestha Niva , Chen Mario , Weissman Amy
Published: January 2020

BACKGROUND

With mobile phone coverage and ownership expanding globally, mobile health (mHealth) interventions are increasingly being used to improve coverage and quality of health and nutrition services. However, evidence on mHealth intervention feasibility and factors to consider during program design is limited in low- and middle-income countries like Nepal.

OBJECTIVE

This study aimed to examine the potential of using text messages to improve health and nutrition services by exploring mobile phone ownership and sharing; mobile phone use and skills; and interest, preferences, and limitations regarding mHealth interventions.

METHODS

We conducted 35 in-depth interviews with 1000-day women (the period from conception to a child’s second birthday), health facility staff, and female community health volunteers (FCHVs), as well as eight focus group discussions with health facility staff, FCHVs, and 1000-day household decision-makers (ie, husbands, mothers-in-law, and fathers-in-law). We also conducted a mobile phone skills test. We employed thematic analysis using framework matrices and analytical memos.

RESULTS

The study included 70 study participants, of whom 68 (97%) had a mobile phone, and phone sharing was uncommon. Use of text messages was most commonly reported by 1000-day women and health facility staff than household decision-makers and FCHVs. More than 8 in 10 participants (54/64, 84%) could dial numbers, and the majority (28/34, 82%) of 1000-day women, health facility staff, and male decision-makers could also read and write text messages. We found that 1000-day women preferred educational and reminder messages, whereas health facility staff and FCHVs desired educational and motivational messages. Participants suggested different types of texts for 1000-day women, families, FCHVs, and health facility staff, and reported less value for texts received from unknown phone numbers.

CONCLUSIONS

A text message–based mHealth intervention is acceptable in the hills of Nepal and has the potential to improve community health and nutrition service utilization, particularly by sending meeting reminders and by providing information. Our findings contribute to text message–based mHealth intervention design in under-resourced settings.
What You Need to Know Before Implementing a Clinical Research Data Warehouse: Comparative Review of Integrated Data Repositories in Health Care Institutions (Preprint)
Authors: Gagalova Kristina K , Leon Elizalde M Angelica , Portales-Casamar Elodie , Görges Matthias
Published: January 2020

BACKGROUND

Integrated data repositories (IDRs), also referred to as clinical data warehouses, are platforms used for the integration of several data sources through specialized analytical tools that facilitate data processing and analysis. IDRs offer several opportunities for clinical data reuse, and the number of institutions implementing an IDR has grown steadily in the past decade.

OBJECTIVE

The architectural choices of major IDRs are highly diverse and determining their differences can be overwhelming. This review aims to explore the underlying models and common features of IDRs, provide a high-level overview for those entering the field, and propose a set of guiding principles for small- to medium-sized health institutions embarking on IDR implementation.

METHODS

We reviewed manuscripts published in peer-reviewed scientific literature between 2008 and 2020, and selected those that specifically describe IDR architectures. Of 255 shortlisted articles, we found 34 articles describing 29 different architectures. The different IDRs were analyzed for common features and classified according to their data processing and integration solution choices.

RESULTS

Despite common trends in the selection of standard terminologies and data models, the IDRs examined showed heterogeneity in the underlying architecture design. We identified 4 common architecture models that use different approaches for data processing and integration. These different approaches were driven by a variety of features such as data sources, whether the IDR was for a single institution or a collaborative project, the intended primary data user, and purpose (research-only or including clinical or operational decision making).

CONCLUSIONS

IDR implementations are diverse and complex undertakings, which benefit from being preceded by an evaluation of requirements and definition of scope in the early planning stage. Factors such as data source diversity and intended users of the IDR influence data flow and synchronization, both of which are crucial factors in IDR architecture planning.
Total Sulfur and Ash Yield of Tanjung Formation Coal in Sekako, Barito Basin, Central Kalimantan: Implication of Depositional Process
Authors: Wiranata Beny , Amijaya Hendra , Anggara Ferian , Perdana Agung Rizki , Isnadiyati Oyinta Fatma , Putra Tanggara Deddy Nan Setya
Published: January 2020

Tanjung Formation is one of the major coal-bearing deposit in the Barito Basin, Central Kalimantan. The distribution of total sulfur and ash yield in coal is closely related to the depositional environment. This study was to determine the total sulfur and ash yield and the interpretation of the dynamics of depositional process. Coal seam A and B generally have low to medium ash yield 2.82 to 9.23 (wt.%, db) and low total sulfur content of <1 (wt.%, db), except for the 6PLY1 coal sample which has total sulfur content that relatively high at 1.55 (wt.%, db). Coal samples 5PLY1A, 5PLY1B, 5PLY3, 5PLY5, 6PLY2, 6PLY4, 6PLY5, 6PLY7, and 6PLY9 which have low to medium ash yield and low total sulfur content <1% (wt.%, db) are formed in the topogeneous mire (freshwater swamp) in a fluvial environment. The total sulfur content was interpreted to be derived mainly from the parent plant materials. Meanwhile, the 6PLY1 coal sample which has an ash yield of 5.83 (wt.%, db) and total sulfur content of 1.55 (wt.%, db) formed in topogeneous mire in an environment that is invaded by sea water, and the total sulfur content were interpreted coming from the parent plant materials and the effect of seawater invasion which is rich in sulfate (SO4) compounds. It is also supported by the occurrence of syngenetic mineral content (framboidal pyrite) and epigenetic pyrite of 1.23 (vol.%).
Relevancia de los estudios de género en las universidades
Authors: Buquet Corleto Ana Gabriela , López González de Orduña Helena , Moreno Esparza Hortensia
Published: January 2020

El 16 de diciembre de 2016, el Pleno del H. Consejo Universitario de la Universidad Nacional Autónoma de México (UNAM) aprobó la propuesta de conversión del Programa Universitario de Estudios de Género (PUEG) en Centro de Investigaciones y Estudios de Género (CIEG). Dicha propuesta se organizó alrededor de tres ejes fundamentales: 1) las funciones sustantivas de la universidad: investigación, docencia y extensión de la cultura; 2) la consolidación de la igualdad de género en la UNAM; y 3) la vinculación con la sociedad. Estos ejes le dan al nuevo Centro rasgos característicos que lo diferencian de otras instancias universitarias. En este trabajo se discute la pertinencia de la creación del CIEG en función de la importancia que los estudios de género han adquirido, tanto en la academia como en la vida social.
Compact left-handed dual-band filters based on shundted stub resonators
Authors: Radonic Vasa , Crnojevic-Bengin Vesna
Published: January 2020

In this paper, super-compact microstrip dual-band resonator is presented,
designed using the superposition of two simple left-handed (LH) resonators
with single shunt stub. The proposed resonator exhibits spurious response in
wide frequency range and therefore allows construction of dual-band filters
using the superposition principle. The equivalent circuit model of the
proposed resonator is crated and the influence of different geometrical
parameters to the performances of the resonator are analyzed in details. As
an examples, two dual-band filters that operate simultaneously at the WiMAX
frequency bands are designed.
Bioremediation of groundwater contaminated with petroleum hydrocarbons applied at a site in Belgrade (Serbia)
Authors: Bulatovic Sandra , Maric Nenad , Solevic-Knudsen Tatjana , Avdalovic Jelena , Ilic Mila , Jovancicevic Branimir , Vrvic Miroslav
Published: January 2020

Due to their extensive use, petroleum hydrocarbons are among the most common groundwater contaminants. Compared to the traditional methods of physical pumping of contamination from the aquifer and subsequent treatment (i.e., pump and treat), bioremediation is an economically cost-effective technology. The aim of this remediation approach is to transform biologically contaminants, most often by microbiological activity, into non-toxic compounds. More precisely, it is an active remediation process that involves biostimulation (increase of aquifer oxygenation, addition of nutrients) and/or bioaugmentation (injection of a concentrated and specialized population of microorganisms). Using both biostimulation and bioaugmentation, enhanced in situ groundwater bioremediation was applied at a hydrocarbon-contaminated site in Belgrade. The bioremediation treatment, applied over twelve months, was highly efficient in reducing the concentrations of total petroleum hydrocarbon (TPH) to acceptable levels. The concentration of TPH in the piezometer P-5 was reduced by 98.55 %, in the piezometer P-6 by 98.30 % and in the piezometer P-7 by 98.09 %. These results provided strong evidence on the potential of this remediation approach to overcome site-limiting factors and enhance microbiological activity in order to reduce groundwater contamination.
Fotovoltaik Güneş Santrallerinde Şebeke Bağlantı Sorunları ve Çözümleri
Authors: ARICI Nursal , ISKENDER Asli
Published: January 2020

Herhangi bir kaynaktan dağıtım sistemine bağlanan güç
santralleri Dağıtık Enerji Santralleri olarak adlandırılır. Türkiye’de 1 MW’tan
daha az güç üreten yenilenebilir kaynaklı santrallerin lisanssız üretim yapma
hakkıbulunmaktadır. Dolayısıyla bu santrallerden biri olan Fotovoltaik (FV)
sistemlerin şebeke bağlantı sorunlarına karşı önceden önlem alınması adına
gelişmiş ülkelerde standartlar geliştirilerek uygulamaya konulmuştur. Ülkemizde
de belirli güçlerdeki lisanssız FV sistemlerin şebekeye bağlantıları için
mevzuatta kolaylıklar sağlanmıştır. FV sistemlerin şebekenin enerji kalitesinde
özellikle de gerilim açısından dalgalanmalar yarattığı da bir gerçektir. Bu tip
şebeke bağlantı sorunlarını azaltarak güç kalitesini iyileştirmeye yönelik
çalışmaların artması fotovoltaiklerin kullanımında önemli avantajlar
sağlayacaktır. Bu çalışmada FV güneş santrallerinin şebekeye bağlantı sorunları
irdelenmiş, önemli sorunların çözümlerine yönelik öneriler getirilmiştir.
KONSTRUKSI INFORMASI POLITIK (STUDI KASUS PADA MASYARAKAT KOTA CIMAHI PASCA PENETAPAN CALON WALIKOTA DAN WAKIL WALIKOTA DALAM PILKADA SERENTAK )
Authors: Slamet Adiyana
Published: January 2020

Konsolidasi demokrasi lokal akan terwujud dengan baik jikalau informasi politik yang diberikan oleh institusi penyelenggara pemilu dan institusi politik melalui proses komunikasi politik dapat mendorong rakyat mendapatkan ‘gizi’ menerima informasi politik sehingga belajar tentang politik. Informasi politik dalam pilkada sentak merupakan bagian dari bagaimana kandidat “pasangan calon” Walikota Cimahi melakukan komunikasi politik untuk berlomba-lomba memberikan informasi politik mengenai prospective policy choice yang akan di usung nantinya. Ketika informasi politik masyarakat itu terpenuhi, tentu masyarakat bisa memilih dengan tanggung jawab besar secara rasional untuk memilih pemimpin di daerahnya berdasarkan pertimbangan-pertimbangan yang “menguntungkan” kepentingan rakyat itu sendiri. Tahun 2017 menjadi tahun politik bagi 101 daerah yang menggelar pemilihan kepala daerah (Pilkada) Seretak di seluruh Indonesia. Terdapat 7 Provinsi, 76 Kabupaten dan 18 Kota yang mengikuti Pilkada serentak tersebut. Salah satu dari 18 Kota yang menggelar Pilkada tersebut adalah Kota Cimahi. Kota Cimahi memiliki daftar pemilih tetap sejumlah 375.722 orang yang menggunakan kedaulatannya untuk memilih pasangan calon Walikota yang akan memimpin daerahnya selama 5 tahun kedepan. Dalam pesta demokrasi menjadi hal fundamental bahwa, informasi politik menjadi penguat dalam kognisi politik yang nantinya di implementasikan pada ruang partisipasi politik itu sendiri. Pemberian informasi politik merupakan sebuah kewajiban bagi penyelenggara pemilu terutama KPU Kota Cimahi dan Partai Politik untuk memberikan Informasi politik kepada masyarakat.
Dinamika Kebijakan Keterlibatan Indonesia dalam Kerjasama Selatan-Seltan (KSS) Periode 2004-2018
Authors: Paramita Rahmadian
Published: January 2020

Foreign Policy, Joko Widodo, South-South Cooperation, Susilo Bambang Yudhoyono
Unsettling Aerial Surveillance: Surveillance Studies after Standing Rock
Authors: Schnepf J.D.
Published: January 2020

Aerial surveillance by unmanned aerial vehicles (UAVs) or drones played a prominent role in the “water is life” actions undertaken by “water protectors” to defend the Standing Rock Sioux Reservation’s water source from the proposed Dakota Access Pipeline (DAPL). By considering how the water protectors deployed drones in their actions, this article shows that decolonizing surveillance studies in the settler-colonial context must follow the work of Indigenous studies scholars in accounting for existing colonial relations. To that end, this article argues that while aerial sousveillance measures constitute a subversive tactical response to organized surveillance by law enforcement and private security firms, the technologies and visualizations on which protest drones depend are imbricated in the workings of capital and empire.
STEGANOGRAFI DENGAN MENGGUNAKAN METODE LSB DAN ALGORITMA HILL CIPHER
Authors: Supratman Sherly Gina
Published: January 2020

AbstrakJaringan Komunikasi seperti Internet� merupakan jaringan yang tidak aman untuk mentransmisi data, seperti teks, audio,video dan citra digital. Salah satu cara untuk pengamanan data dapat dilakukan dengan menggunakan proses kriptografi dan �steganografi. Penggunaan ini dengan tujuan untuk merahasiakan pesan yang dikirim dan sekaligus menghindarkan pesan tersebut dari kecurigaan pihak lain yang tidak berkepentingan.Pesan yang digunakan dalam makalah ini adalah berupa text dengan menyisipkannya pada gambar. Pada proses kriptografi, pesan yang berupa text akan dienkrip dengan algoritma Hill Chiper, dan kemudian pesan yang telah dienkrip akan dilakukan proses steganografi pada citra digital� 8 bit dengan skala 0 � 255, dengan metode Least Significant Bit ( LSB ).�Kata kunci: Kriptografi, Hill Chiper, Steganografi, Least Significant Bit�AbstractCommunication Networks such as the Internet are unsafe networks for transmitting data, such as text, audio, video and digital imagery. One way to secure data can be done by using cryptography and steganography process. This use is for the purpose of concealing messages being transmitted and avoiding such messages from the suspicion by others who are not interested.The message used in this paper is text by inserting it in the image. In the cryptographic process, text messages will be encrypted with the Hill Chiper algorithm, and then the encrypted message will be steganographed on 8-bit digital images on a scale of 0-255, using the Least Significant Bit (LSB) method.�Keywords: Cryptography, Hill Chiper, Steganography, Least Significant Bit
Tecendo habilidades empáticas: uma experiência com crianças e adolescentes
Authors: Oliveira Mychelle Maria Santos de , Silva Maria Camila da , Costa Sara Raquel Araújo , Silva Teresinha de Jesus Sousa , Andrade Maria do Perpétuo Socorro Gonçalves , Conceição Pedro Wilson Ramos da , Castro Avelino Ribeiro , Said Érika Castelo Branco , Lemos Ana Valéria Lopes , Carvalho Izabel Cristina Vale de , Araújo Zaira Arthemisa Mesquita , Gonçalves Francisca Tatiana Dourado
Published: January 2020

Objetivo: Relatar as experiências advindas da aplicação de um projeto de intervenção, realizado em um Centro da Juventude. Detalhamento do Caso: O projeto é resultado do Estágio Básico em Psicologia Social e Comunitária. As intervenções foram realizadas durante oito encontros, com o público infantil e juvenil do Centro da Juventude de um município do interior do Maranhão, durante o primeiro semestre de 2019. As atividades foram realizadas com aproximadamente trinta assistidos e os instrumentos foram selecionados para atuar em prol do coletivo. Para isso, utilizou-se as dinâmicas de grupo e os jogos cooperativos com a finalidade de estimular a empatia e promover o autoconhecimento e reconhecimento do próximo entre os assistidos desse equipamento.  Considerações Finais: O uso de atividades dinâmicas e cooperativas mostrou-se eficaz para o exercício da prática do respeito, escuta e de um novo olhar sobre o outro, logo, contribui com o fortalecimento de vínculo entre os assistidos e promove bem-estar.
Hydroxamic Acid-Modified Peptide Microarrays for Profiling Isozyme-Selective Interactions and Inhibition of Histone Deacetylases
Authors: Moreno-Yruela Carlos , Vrsanova Adela-Eugenie , Maric Hans M. , Olsen Christian Adam
Published: January 2020

Histones control gene expression by regulating chromatin structure and function. The posttranslational modifications (PTMs) on the side chains of histones form the epigenetic landscape, which is tightly controlled through the enzymatic action of epigenetic effector proteins and protein complexes. Further, various PTM signatures or combinations are recognized by so-called reader domains. Histone microarrays have been widely applied to investigate such histone–reader interactions. So far, however, these could not be used to directly study the fast and transient interactions of Zn2+-dependent histone deacetylase (HDAC) enzymes. Here, we describe the synthesis of hydroxamic acid-modified histone-derived peptides and their use in femtomolar microarrays for the direct capture and detection of the four class I HDAC isozymes. We further demonstrate their suitability to discover and map HDAC isozyme-specific substrates. Functional assays confirmed the prediction of HDAC–peptide binding requirements and the conversion of acetylated substrates in response to PTMs and mutations. Subsequent analysis of the hydroxamic acid-containing peptides identified compounds with nanomolar potency and unanticipated selectivity. Follow-up analyses confirmed a major contribution of the peptide sequence to substrate turnover, inhibitor potency, and isozyme selectivity. We conclude that similar hydroxamic acid-modified histone peptide microarrays and libraries could find broad application to identify class I HDAC isozyme-specific substrates and facilitate the development of isozyme- or protein complex-selective HDAC inhibitors and affinity probes.
Análisis del mapeo sistemático de Facebook para Empresas
Authors: Villegas Valle Lily , García Báez Mary Tere
Published: January 2020

El objetivo de este estudio es analizar la literatura sobre Facebook Empresas y detectar los vacíos existentes en las publicaciones de 2015-2019. Se realizó un mapeo sistemático de la literatura, clasificando la información, identificando la metodología y limitaciones utilizadas en las publicaciones. Para el desarrollo de la investigación se utilizaron las bases de datos EBSCO, Elsevier, Google Académico, Mendeley y Nature generando una muestra inicial de 281 artículos. Finalmente se propone como investigaciones futuras el enfoque concerniente a Facebook Blueprint así cómo la utilización de formas innovadoras como Big Data y Deep Learning que den paso a estudios intersectoriales e interculturales.
Turismofobia: un análisis social desde los medios de comunicación
Authors: Ramírez Vázquez Evelin , De la Cruz Davila Jacqueline
Published: January 2020

El origen de la turismofobia se encuentra relacionado con otros efectos psicosociales negativos del turismo que, de manera directa o indirecta, afectan tanto al medio ambiente como a los residentes del lugar turístico. Los medios de comunicación sin lugar a duda, se han convertido en los principales portadores de titulares relevantes y sorprendentes sobre el tema; problemas que realmente preocupan, aunque las autoridades correspondientes no lo quieran reconocer.
La poesía de la intimidad: Displazement como recurso para alcanzar la libertad
Authors: Paulín Ríos María Teresa , Pérez Cesari María de Lourdes , Simón Fuentes Mayra Edith
Published: January 2020

Resultado de un proyecto de investigación titulado Creación transdisciplinaria en espacios alternativos a partir del Displazement, financiado por el Programa de Mejoramiento del Profesorado (PROMEP), la puesta en escena de Altazor o el viaje en paracaídas, se presentó en el Instituto de Artes de la Universidad Autónoma del Estado de Hidalgo (UAEH). El objetivo de esta investigación fue la creación de un espacio íntimo a través de un lenguaje generado a partir del sincretismo entre el displazement  (variante del parkour) y el teatro. Este artículo es un estudio que recoge, organiza y examina los elementos que integran la creación del espacio escénico y muestra la visión de un proyecto transdisciplinar que utiliza la técnica de una disciplina urbana, como recurso para alcanzar la libertad.
Evaluation of the resistance to insecticides in Aedes aegypti, transmitter of dengue, in Latin America
Authors: Hernández Ramos Amparo Gabriela
Published: January 2020

Dengue is an infectious disease with high rates of morbidity and mortality, transmitted by the bite of the female mosquito of the genus Aedes aegypti, vector distributed in tropical and subtropical areas throughout the world. America is one of the most affected regions. This vector is controlled through insecticides that due to its constant use in populations, a resistance phenomenon has been produced. The objective of this review is to identify the situation of insecticide resistance in populations of Aedes aegypti in Latin American countries. In this region, several insecticides have been used for vector control; in the last 10 years insecticides of the pyrethroid and organophosphorus group have been used as adulticides for the control of the mosquito, conditioning resistance. Some insecticides such as organophosphates and deltamethrin, despite of not being intensively used in Latin American countries, also show resistance. Improvements in vector control are required, including the rotation of the insecticides during the different seasons, as well as innovating techniques and forms of vector control