bluuebunny/crossref_metadata_2025 huggingface dataset:
A rare case of knee joint mucormycosis with pathological fracture after COVID-19 infection
Authors: Iordache Sergiu Andrei , Cursaru Adrian , Şerban Bogdan , Popa Mihnea Ioan Gabriel
Published: August 2021

Mucormycosis is a fungal infection that generally occurs in patients with some degree of immunosuppression, such as patients with malignancies, diabetes, HIV infection, or patients who require the administration of immunosuppressive drugs.

The final diagnosis is established by collecting some tissue from the infectious process and isolating the fungus using lab cultures.

The treatment of mucormycosis is complex and consists of trying to reduce risk factors, rigorous surgical debridement, and specific antifungal treatment.

We present the case of a 54-year-old male patient with a background of SARS-COV2 infection (moderate form), that started 3 months prior to presentation to our hospital, initially treated at home.

The patient presented to the Orthopaedics Department of the University Emergency Hospital of Bucharest with pain and total functional impotence in his left knee as a result of a trauma that occurred about 2 months before the presentation to the hospital, at that moment with progressive worsening of the symptoms. Clinical and imaging examination established the diagnosis of pathological supra-intercondylar fracture of the left femur.

The purpose of this case report is to present the risk of infection with an opportunistic agent as a result of immunosuppression induced by COVID-19 or its treatment with immunosuppressive agents necessary to combat the inflammatory process. The patient presented with a moderate form of COVID-19 treated at home with nonsteroidal anti-inflammatory drugs and antibiotics to prevent a bacterial superinfection.

Mucormycosis remained a challenging situation for the physician, regardless of his medical specialty, both in terms of diagnosis and treatment. In this case, COVID-19 is one of the risk factors that contributed to the appearance of mucormycosis.
ONLINE AND PHYSICAL STORES: DETERMINANT FACTORS INFLUENCING THE PURCHASING DECISION AND CUSTOMERS SATISFACTION
Authors:   Bucharest University of Economic Studies, Romania, CARAMAN Alina , RACOVIȚA Maria ,   Bucharest University of Economic Studies, Romania, GORA Ana Alexandra ,   Bucharest University of Economic Studies, Romania
Published: August 2021

Over the last 20 years, there have been significant changes in the retail sector, which have been mainly influenced by technological advances, that have radically transformed the customer experience. This research contributes to the enrichment of the existing literature by examining new purchasing trends concerning the transition to the online environment caused by the COVID19 pandemic. For an indepth understanding of the topic, five determinants of the purchasing decision were identified: informativeness, social presence, sensory marketing, product type and brand trust. This study researched, using multi-line analysis, how these factors influence the customer degree of satisfaction regarding online and physical stores. The main results show that customer satisfaction is differently influenced by these factors, depending on the type of store, namely online or physical. These findings demonstrate that companies should adopt different business strategies, focusing on sensory marketing in physical stores and brand trust, together with informativeness in the online ones.
Cleantech: Prospects and Challenges
Authors: Shakeel Shah Rukh
Published: August 2021

The issue of climate change, greenhouse gas emissions, global warming, and their effect on nature and the ecosystem has raised serious concerns. The desire to sustain economic growth and development while keeping a check on the environmental footprints is one of the leading challenges the contemporary world is currently facing. To ensure sustained growth, there is a need for technologies and solutions that has the potential to meet industrial needs without compromising the environment. Cleantech offers a possibility to address these needs in a sustainable and environmentally friendly manner. Cleantech, being an umbrella term, is often confused and misunderstood, in terms of its definition and scope. This study seeks to explore what cleantech actually is, how this sector came into prominence, what are the driving factors behind its surge, and what kind of socio-economic, technical, and regulatory prerequisites are necessary for the advancement of this sector.
Avatares de la antropología histórica: XX años de reflexión
Authors: Kuri Camacho José Francisco Javier , Millán Vásquez Cristina María
Published: August 2021

Este libro es resultado del trabajo de un grupo de académicos de la Licenciatura en Antropología Histórica que han reflexionado sobre cinco campos de conocimiento, a saber: vida cotidiana, espacio social, cuerpo, identidad y memoria colectiva. Estas categorías fueron analizadas en los procesos de aprendizaje en el aula y en el trabajo sobre terreno, análisis que se efectúa como parte sustancial de la investigación y de la formación profesional de los futuros egresados. La tradición de la antropología en general, y de la licenciatura en particular, se caracteriza por la interdisciplinariedad y por su preocupación por la sociedad. En las dos últimas décadas del siglo xxi se están revisando las acciones de las sociedades para hacer y estar en este mundo, por tanto, es necesario no solo difundir los aportes, retos, enfoques y posturas de la antropología histórica, sino también su pertinencia social, algo que ha sido permanente desde su creación.
İç Denetim Süreçlerini İyileştirme ve Risk Yönetimi Araçları: Yalın Altı Sigma ve FMEA
Authors: KARDEŞ SELİMOĞLU Seval , YEŞİLÇELEBİ Gül , ALTUNEL Mehtap
Published: August 2021

İşletmelerin yapısında var olan karmaşıklık, 2019 yılı itibariyle dünyayı etkisi altına alan COVID-19 salgını ile daha da karmaşık hale gelmiştir. İşletmelerin iş yapış şekillerini değiştirmesi ve salgından korunmak adına alınan önlemler kapsamında, faaliyetlerin uzaktan yürütülmesi birçok riski de beraberinde getirmiştir. Her geçen gün artan risklerle birlikte, iç denetimin etkin şekilde yürütülmesinin önemi artmış ve yeni yaklaşımların kullanılması zorunlu hale gelmiştir. Bu çalışmada, iç denetimde süreçlerin iyileştirilmesi ve risklerin belirlenmesi aşamalarında kullanılmak üzere, risk yönetim aracı olarak Yalın Altı Sigma kapsamında sunulan Tanımla-Ölçme-Analiz Etme-İyileştirme-Kontrol (Define-MeasureAnalyze-Improvement-Control/DMAIC ) modeli ve bu model içerisine gömülü olan Hata Türü ve Etkileri Analizi (Failure Mode and Effects Analysis-FMEA) aracı olmak üzere iki yaklaşım önerilmiştir. Çalışmada, iç denetimin Yalın Altı SigmaDMAIC modeli ve Hata Türü ve Etkileri Analizi ile olan ilişkisi incelenmiştir. Süreçlerin iyileştirilmesinde kullanılan birçok yaklaşım olmakla birlikte, çalışma kapsamında önerilen bu iki yaklaşım, özellikle iş süreçlerinin verimliliğine, etkililiğine ve tutumluluğuna odaklanan iç denetimin, riskleri değerlendirmesi, süreçteki zayıflıkları belirlemesi ve iyileştirilmesi için tavsiyelerde bulunmaktadır.
PROSES PENENTUAN MAKNA FILOSOFIS BANGUNAN PENANDA DAERAH ISTIMEWA YOGYAKARTA
Authors: Kuswalastri R.Aj Siti Cut Alia
Published: August 2021

DIY diharapkan memiliki penanda baru yang dapat merepresentasikan nilai-nilai filosofis serta meneguhkan entitasnya sebagai kota yang mengalami perkembangan di bidang pendidikan, budaya, dan pariwisata. Untuk itu, dalam perancangannya dibutuhkan proses menentukan makna filosofis yang relevan ke dalam wujud tanda, agar transformasi konsep dan bentuk maupun tatanan saling berkesinambungan. Penanda Yogyakarta harus dapat menampilkan citra sebagai representasi lingkungannya, melalui karakteristik dan nilai-nilai filosofis sebagai makna atau pesannya. Tujuan penulisan ini adalah untuk menggambarkan proses dalam menentukan makna filosofis penanda Yogyakarta. Digunakan metode kualitatif, pengumpulan data dengan studi literatur terkait filosofi, teori, dan penanda di Yogyakarta, serta observasi lokasi dan bangunan-bangunan terkait konteks ikut ditentukan sebagai alternatif isu penanda. Isu kemudian disandingkan dengan teori yang ada, disajikan dalam bentuk matriks tabel, untuk dicari relevansinya satu dengan yang lainnya. Hasilnya akan menunjukkan tahapan-tahapan penentuan makna mengacu pada teori yang ada sebagai perkuatan dan dasar, isu mana yang relevan dijadikan sebagai makna penanda selain metode yang menunjukkan perlunya proses rasional dan intuisi untuk mengambil suatu keputusan.
Implementation of Urban Open Space as an Active Recreational Area on West Java Art and Cultural Center
Authors: Zita Faizah Rasya
Published: August 2021

Among the physical that facilitace urban development, public open space is singularly responsible for improving urban quality. Open Space is an elongated area / lane and / or group, which used by the community. Open Space can create a character of urban society for social interaction that can united all members of the community without distinguishing social, economic and cultural backgrounds. The observation proves that area surrounding west java art and cultural center does not have an open space area that can facilitate social interaction between community members. This causes a slums around the site area which can’t be used by the comunnity to enjoyed. Therefore, it is necessary to design an open space in the outside of west java art and cultural center building, that can be used as an active recreational area to accommodate public activities as much as possible.
SIRKULASI ANTARA WAYANG ORANG, MUSEUM, & PERPUSTAKAAN DI KAWASAN SRIWEDARI, SURAKARTA - JAWA TENGAH
Authors: Alyanuha Aisya Nada
Published: August 2021

Taman Sriwedari adalah kawasan publik yang mempunyai nilai sejarah. Letaknya dianggap strategis karena berada pada tepi Jl. Brigjen Slamet Riyadi yang merupakan sirkulasi utama. Taman Sriwedari bukan hanya untuk pagelaran wayang orang namun, ada beberapa fasilitas penunjang diantaranya museum dan perpustakan yang saling berkesinambungan. Kenyataanya bangunan utama dengan bangunan penunjang tidak terintegrasi dengan baik sehingga kesinambungan antar fasilitas dan fungsi tidak terasa. Kajian dilakukan dengan memahami dan mengkaji keselarasan konsep ahli terhadap data dilapangan. Hasil kajian digunakan untuk mendesain pergerakan manusia dan sirkulasi pada kawasan. Hasil kajian didapat adalah pola jaringan, pengunjung secara leluasa dapat menetukan arah massa yang ditujunya.
PENDEKATAN NEO VERNAKULAR PADA PENGOLAHAN BENTUK ATAP PASAR WISATA KOTA BATU SEBAGAI EFISISENSI PELESTARIAN
Authors: Farhani Aulia
Published: August 2021

Bentuk atap ciri neo-vernakular menjadi karakter utama bangunan di wilayah pulau jawa dan sekitarnya. Bentuk atap merupakan penyesuian dari lingkungan sekitar dan perkembagannya. Perancangan bangunan pasar wisata perlu menampilkan karakter lokal tersebut dengan pendekatan neo-vernakular melalui pengolahan bentuk atapnya. Tulisan ini bertujuan untuk mengeksplorasi bentuk atap pada perancangan Pasar Wisata Kota Batu. Untuk mencapai tujuan tersebut, penelitian ini menggunakan metode berupa studi literatur serta membuat alternatif desain bentuk atap bangunan dengan prinsip Arsitektur Neo-Vernakular. Hasil eksplorasi ini menghasilkan desain bentuk atap kota batu berdasarkan modifikasi bentuk atap pelana dengan atap silang.The shape of the neo-vernacular roof is the main character of the building in the area of Java Island and its surroundings. The shape of the roof is an adjustment of the surrounding environment and development. The design of the tourist market building needs to display the local character with a neo-vernacular approach through the processing of the roof shape. This paper aims to explore the shape of the roof in the design of the Batu City Tourism Market. To achieve this goal, this research uses a method in the form of a literature study as well as an alternative design of the building roof shape with the principles of Neo-Vernacular Architecture. The results of this exploration resulted in the design of the shape of the stone city roof based on the modification of the shape of the gable roof with a cross roof.
PEMILIHAN TEKNOLOGI PIPA CAHAYA SEBAGAI ALTERNATIF PENCAHAYAAN SIANG HARI PADA BANGUNAN KOMERSIL
Authors: Rofi Willy , Santoso Dermawati Djoko , Poernomo Endhi Ibuhindar
Published: August 2021

Pencahayaan merupakan salah satu bagian yang penting dalam sebuah ruangan. Tanpa cahaya, manusia  akan kurang optimal dalam merasakan suasana ruang.Sejumlah inovasi telah banyak dilakukan untuk menghasilkan alternatif penggganti lampu sebagai sumber cahaya yang hemat energi dengan berbagai cara pengaturan pencahayaannya salah satunya yaitu, teknologi pipa cahaya (Light Pipe). Tulisan ini memaparkan salah satu teknologi pencahayaan yang hemat energi dengan cara mendistibusikan cahaya matahari ke dalam ruangan yang bertujuan untuk menjadi referensi bagi perancang bangunan, khususnya bangunan komersil agar dapat menghemat energi listrik hingga 40%. Metode yang akan digunakan dalam penelitian ini menggunakan pendekatan kualitatif dengan studi literatur. Pengolahan data menggunakan data primer dengan studi preseden. Tulisan ini diharapkan bahwa pipa cahaya ini memiliki potensi yang besar untuk digunakan secara luas di Indonesia.Pencahayaan merupakan salah satu bagian yang penting dalam sebuah ruangan. Tanpa cahaya, manusia  akan kurang optimal dalam merasakan suasana ruang.Sejumlah inovasi telah banyak dilakukan untuk menghasilkan alternatif penggganti lampu sebagai sumber cahaya yang hemat energi dengan berbagai cara pengaturan pencahayaannya salah satunya yaitu, teknologi pipa cahaya (Light Pipe). Tulisan ini memaparkan salah satu teknologi pencahayaan yang hemat energi dengan cara mendistibusikan cahaya matahari ke dalam ruangan yang bertujuan untuk menjadi referensi bagi perancang bangunan, khususnya bangunan komersil agar dapat menghemat energi listrik hingga 40%. Metode yang akan digunakan dalam penelitian ini menggunakan pendekatan kualitatif dengan studi literatur. Pengolahan data menggunakan data primer dengan studi preseden. Tulisan ini diharapkan bahwa pipa cahaya ini memiliki potensi yang besar untuk digunakan secara luas di Indonesia.
A influência da irisina na memória em pacientes com doença de Alzheimer: revisão narrativa
Authors: Baltokoski Kenderly Camila , Accardo Camila de Melo
Published: August 2021

Objetivo: Revisar a literatura sobre a influência da irisina na memória em pacientes com doença de Alzheimer, através do exercício físico. Revisão Bibliográfica: O exercício físico de resistência promove efeitos positivos na função cognitiva e na plasticidade geral do cérebro, podendo inibir ou retardar o surgimento de doenças neurodegenerativas, como a doença de Alzheimer, através da liberação de mioquinas na corrente sanguínea por meio da atividade endócrina da contração das fibras musculares. A irisina é uma mioquina capaz de proteger o hipocampo, região do cérebro envolvida centralmente no aprendizado e na memória, ao estimular a expressão de fatores neurotróficos, como o fator neurotrófico derivado do cérebro que está envolvido na neuroplasticidade, neurogênese, sobrevivência neuronal, sinaptogênese e cognição. Considerações Finais: Há fortes evidências de que a irisina é capaz de proteger o hipocampo e influenciar na evolução das doenças neurodegenerativas. Contudo, ainda são necessários estudos em maior escala para esclarecer a relação desses fatores na fisiopatologia da doença de Alzheimer e, posteriormente, o possível teor terapêutico.
Variations and management for patients with craniocervical junction arteriovenous fistulas: Comparison of dural, radicular, and epidural arteriovenous fistulas
Authors: Matsubara Shunji , Toi Hiroyuki , Takai Hiroki , Miyazaki Yuko , Kinoshita Keita , Sunada Yoshihiro , Yamada Shodai , Tao Yoshifumi , Enomoto Noriya , Minami Yukari Ogawa , Hirai Satoshi , Yagi Kenji , Nakashima Hiroyuki , Uno Masaaki
Published: August 2021

Background:

Craniocervical junction arteriovenous fistulas (CCJAVFs) are known to be rare, but variations and clinical behaviors remain controversial.

Methods:

A total of 11 CCJAVF patients (M: F=9:2, age 54–77 years) were investigated. Based on the radiological and intraoperative findings, they were categorized into three types: dural AVF (DAVF), radicular AVF (RAVF), and epidural AVF (EDAVF).

Results:

There were four symptomatic patients (subarachnoid hemorrhage in two, myelopathy in one, and tinnitus in one) and seven asymptomatic patients in whom coincidental CCJAVFs were discovered on imaging studies for other vascular diseases (arteriovenous malformation in one, intracranial DAVF in two, ruptured cerebral aneurysm in two, and carotid artery stenosis in two). Of these 11 patients, 2 (18.2%) had multiple CCJAVFs. Of 14 lesions, the diagnoses were DAVF in 5, RAVF in 3, and EDAVF in 6 (C1–C2 level ratio =5:0, 2:1, 3:3). Patients with DAVF/RAVF in four lesions with intradural venous reflux underwent surgery, although an RAVF remained in one lesion after embolization/radiation. Since all six EDAVFs, two DAVFs, and one RAVF had neither feeder aneurysms nor significant symptoms, no treatment was provided; of these nine lesions, one DAVF and one RAVF remained unchanged, whereas six EDAVFs showed spontaneous obliteration within a year. Unfortunately, however, one DAVF bled before elective surgery.

Conclusion:

CCJAVFs have many variations of shunting site, angioarchitecture, and multiplicity, and they were frequently associated with coincidental vascular lesions. For symptomatic DAVF/RAVF lesions with intradural drainage, surgery is preferred, whereas asymptomatic EDAVFs without dangerous drainage may obliterate during their natural course.
Cauda equina arteriovenous fistula supplied by proximal radicular artery and concomitant sacral dural arteriovenous fistula: A case report and literature review
Authors: Iampreechakul Prasert , Lertbutsayanukul Punjama , Siriwimonmas Somkiet
Published: August 2021

Background:

Cauda equina arteriovenous fistulas (AVFs) fed by the proximal radicular artery are exceedingly rare. Spinal dural arteriovenous fistulas (DAVFs) in the sacral region are rare and usually misdiagnosed. We report a case of a cauda equina AVF with concomitant sacral DAVF. We also review the coexistence of multiple types of spinal vascular malformations in a single patient.

Case Description:

A 54-year-old man presented with progressive weakness of the lower extremities for 1 month. Magnetic resonance imaging (MRI) of the lumbosacral and thoracic spine showed spinal cord congestion, extending from the conus medullaris to the level of T7, and abnormal tortuous and dilated flow void, running from the level of L5 to T12 along anterior surface of the spinal cord. Spinal angiography demonstrated the fistula at the level of L2 below the conus medullaris. Based on intraoperative findings, the cauda equina AVF supplied by the proximal radicular artery with cranial drainage through the enlarged radicular vein was confirmed and successfully obliterated. Another enlarged arterialized radicular vein running parallel to another cauda equina nerve root is observed with unknown origin. After the operation, the patient showed mild improvement of his symptoms. Follow-up MRI and contrast-enhanced MR angiography revealed an another sacral DAVF vascularized by the lateral sacral artery.

Conclusion:

The coexistence of different spinal vascular malformations in a same patient is extremely rare. Most authors of several studies hypothesized that venous hypertension and thrombosis due to the presence or treatment of the first spinal vascular lesion may produce a second DAVF.
Cuidado com o diagnóstico clínico da tendinite da para de ganso em corredores recraacionais: pode se fratura por estresse no planalto tibial medial. Relato de dois casos
Authors: Santos Netto Alfredo dos , Rodrigues Luana Queila , Garotti José Eduardo Rossetto
Published: August 2021

Introdução: O diagnóstico de fratura por estresse no planalto tibial medial pode ser confundida com outros diagnósticosdiferencias, justamente porque o local de dor e sensibilidade a palpação é muito semelhante a lesões meniscais e tendiniteda pata de ganso, que são lesões comuns em pacientes corredores. Objetivo: Relatar dois casos que foram interpretadosinicialmente como tendinite na pata de ganso na avaliação inicial, e após reavaliação ambulatorial, foi realizado diagnósticode fratura por estresse bilateral no planalto tibial medial. Relato dos Casos: Duas pacientes do sexo feminino, 31 e 32 anos respectivamente, começaram a prática de corrida de rua, sem supervisão, e seis e oito semanas após o início da prática, evoluíram com dor nos joelhos, bilateralmente, na face medial. Na avaliação inicial o quadro foi interpretado como tendinite da pata de ganso. Como não tiveram melhora, procuraram novo atendimento médico, em que foi feito suspeita diagnóstica de fratura por estresse no planalto tibial medial, e foram solicitados exames de ressonância magnética bilateral, que confirmaram o diagnóstico. Ambas as pacientes foram tratadas de forma conservadora, com restrição para atividades de impacto por 6 semanas, carga conforme dor, analgesia simples com dipirona, gelo, e ibandronato sódico por 2 meses. As pacientes  retornaram após 6 semanas com  melhora clínica. Após sessões de fisioterapia foram liberadas para atividades de impacto com sucesso. Conclusão: Esses casos enfatizam a importância da suspeita diagnóstica de fratura por estresse no planalto tibial medial em pacientes corredores recreacionais com quadro de dor na região medial do joelho, principalmente se houve uma mudança no seu padrão ou intensidade de corrida.

Palavras chave: Joelho, Fratura por estresse, Fraturas da tíbia
Pharmacogenetic markers of chemotherapy toxicity in gastrointestinal tumors: a preliminary analysis
Authors: Fedorinov Denis S. , Geidarov Rustam N. , Shashkov Igor A. , Mikhailovich Vladimir M. , Lyadova Marina A. , Pokataev Ilya A. , Lyadov Vladimir K.
Published: August 2021

Aim. To assess the association between the carriage of minor allelic variants of 8 genes that encode key enzymes involved in the metabolism of anticancer drugs (DPYD, GSTP1, MTHFR, UGT1A1) and cell repair (XPC, ERCC1, TYMP, NQO1) and the severity of adverse drug events in patients with common gastrointestinal tumors. Tasks. To study the frequency of minor allelic variants of the DPYD, GSTP1, MTHFR, UGT1A1, XPC, ERCC1, TYMP, NQO1 genes; to assess the frequency and severity of adverse drug events of chemotherapy treatment in the study population. Materials and methods. For the period from October 2020 to April 2021, 56 patients (women 29, men 27) with verified malignant tumors of the gastrointestinal tract were included in a prospective clinical study as a part of the RSF grant No. 20-75-10158. The mean age was 62.311.4 years. Colon cancer was detected in 24 patients, tumors of the esophagus and stomach in 19 patients, tumors of pancreas and biliary tract in 13 patients. First-line palliative chemotherapy was given to 27 patients, adjuvant 19 patients, neoadjuvant 10 patients. All patients had not previously received cytotoxic or radiation treatment. Point nucleotide variants of genes DPYD, XPC, GSTP1, MTHFR, ERCC1, UGT1A1, TYMPS, NQO1 were determined by hybridization analysis on biological microchips. Differences in the tolerance of cytotoxic therapy (5-fluorouracil, platinum preparations, irinotecan) depending on the genotype were assessed using Fishers exact test. Results. The average number of chemotherapy courses received was 4.22.6 (112). There was a statistically significant difference in the tolerability of chemotherapy in patients with minor allelic variants of the GSTP1 rs1695 (p=0.03), ERCC1 rs11615 (p=0.01), and UGT1A1 rs8175347 (p=0.003) genes. Conclusion. The use of hybridization analysis on biological microchips to assess allelic variants responsible for the tolerability of cytotoxic therapy is reasonable and requires further prospective assessment.
Prostate cancer
Authors: Kaprin Andrei D. , Alekseev Boris Ia. , Matveev Vsevolod B. , Pushkar’ Dmitrii Iu. , Govorov Aleksandr V. , Gorban’ Nina A. , Kirichek Andrei A. , Biriukov Vitalii A. , Volkova Mariia I. , Gulidov Igor A. , Gumenetskaia Iuliia V. , Krylov Valerii V. , Kariakin Oleg B. , Krasheninnikov Aleksei A. , Mardynskii Iurii S. , Niushko Kirill M. , Zakharova Tatiana I. , Kostin Andrei A. , Khmelevskii Evgenii V. , Fedenko Aleksandr A. , Bolotina Larisa V. , Falaleeva Natalia A. , Filonenko Elena V. , Nevol’skikh Aleksei A. , Ivanov Sergei A. , Khailova Zhanna V. , Gevorkian Tigran G.
Published: August 2021

Prostate cancer (RPP) is a malignant neoplasm that arises from the epithelium of the prostate gland gland (PJ). рак предстательной железы; клинические рекомендацииThethiology and pathogenesis of this disease remain poorly studied. Many studies are aimed at studying diet, food, hormonal impact, as well as infections in the etiology of the RLPG. The prevalence of RPL depends on ethnic and geographical features. The highest incidence of African Americans living in the United States (60% higher than that of white Americans), the least high - in the Chinese living in China [1]. In addition to racial features, the risk factors of the RPG are considering the genetic predisposition, the age of men and nutritional features. The probability of developing a PJ tumor in a man who has one of the closest relatives of the first degree of kinship (father or brother) sick of the RLPG, is 1.8 times higher than in the population. If two relatives were sick or more (father and brother or both brothers), the risk of RPG increases in 5.51 and 7.71 times, respectively [2, 3]. African Americans have an increased risk of identifying RPG, as well as a greater probability of detecting aggressive RPG [4]. Also, the risk of RLPG is rising in men who use a large amount of animal fats [5].
PRODUÇÕES CIENTÍFICAS: abordagens pedagógicas da utilização da plataforma YouTube
Authors: Alarcon Andressa Mayumi Yamashiro , Novello Tanise Paula
Published: August 2021

O site YouTube se configura como uma plataforma que permite a participação coletiva de seus usuários por meio do compartilhamento de vídeos online. A presente pesquisa tem um olhar para o viés educacional existente na plataforma, em especial para as múltiplas concepções sobre o uso do YouTube no contexto educacional de ciências nas pesquisas de pós-graduação em nível nacional. Dessa maneira, o objetivo geral consiste em compreender de que forma as pesquisas relacionadas ao YouTube abordam a utilização da plataforma como um instrumento pedagógico em ciência. Para esse estudo optou-se por uma pesquisa qualitativa do tipo documental, das pesquisas do Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os dados desse levantamento foram obtidos considerando as palavras-chave YouTube e vídeo, e as variações vídeos, YouTuber e YouTubers. O corpus de análise da pesquisa é composto de seis dissertações, que correspondem aos anos de 2010 a 2020. A partir da análise interpretativa dos dados, constituíram-se duas categorias: “A utilização pedagógica da plataforma” e “Propostas para o uso do YouTube como ferramenta pedagógica”. As categorias elencadas evidenciam o uso da plataforma enquanto ferramenta pedagógica, na busca por estabelecer parâmetros de estudos para a utilização dos vídeos no contexto educacional e de compreender as motivações dos produtores de conteúdo ao divulgar a ciência no contexto online. Por fim, foi possível realizar apontamentos sobre quais são os desdobramentos educacionais presentes na plataforma e ainda destacar alguns encaminhamentos e perspectivas incisivas para futuras pesquisas sobre a temática.
Comparative study of postoperative analgesia intrathecal addition of fentanyl versus clonidine in lower limb surgeries
Authors:   Post Graduate Student, Department of Anaesthesia, Government Medical College, Jammu, INDIA., Gupta Palak
Published: August 2021

Background: Local anesthetic drugs like bupivacaine are commonly used in spinal anesthesia for lower limb surgeries but the duration of spinal anaesthesia is very short. However, the duration of action of bupivacaine in spinal anaesthesia can be prolonged by using adjuvants such as midazolam, opioids, neostigmine, dexmedetomidine and clonidine. The present study is being undertaken to evaluate and compare the effects of clonidine and fentanyl as intrathecal adjuvants to hyperbaric bupivacaine in patients undergoing lower limb orthopaedic surgery. Material and Methods: Present study was conducted in the Department of Anaesthesiology and Intensive Care, Government Medical College, Jammu in patients of either sex ranging in age from 20-60 years belonging to ASA I/ II scheduled for lower limb orthopaedic surgeries. 90 patients were randomly allocated in three groups of 30 each in order to compare the duration and quality of analgesia of clonidine and fentanyl used as adjuvants to intrathecal bupivacaine. Results: All the three groups were comparable in age, gender, height, weight, ASA grade distribution and the difference between them was not statistically significant. The difference between the time to reach the T10 block, mean time taken for first request for analgesia and duration of motor block in all three groups were found out to be statistically significant (p<0.0001). It was found that group with clonidine had better results than fentanyl and bupivacaine alone. In our study 1 patient in bupivacaine (15mg) with fentanyl (25µg) group and 2 patients in clonidine(37.5ugm) group had hypotension but the difference was statistically insignificant. Only 1 patient in each fentanyl and clonidine group had 1 episode of bradycardia but no patient in bupivacaine alone group had bradycardia and the difference was also insignificant. Postoperative vomiting was experienced by 3.33% of patients receiving Bupivacaine (15mg) with fentanyl (25µg) and it was treated by giving injection Ondansetron 4 mg i/v whereas no case was reported in clonidine group. This difference was statistically insignificant. 2 patients in bupivacaine (15mg) with fentanyl (25µg) group had itching but no such case was reported in clonidine group and the difference was also statistically insignificant. No respiratory depression, nausea was noted in study patients. Conclusion: It can be concluded that intrathecal clonidine (37.5ugm) provides quicker onset and prolonged duration of sensory and motor blocks simultaneously increasing the duration of analgesia when compared to fentanyl (25ugm).
The effect of perioperative esmolol infusion on the postoperative pain and nausea vomiting after middle ear surgeries
Authors:   Senior Resident,  Department of Anaesthesiology, P.D.U Medical College and Hospital, Rajkot, INDIA., Adhiya Payal P
Published: August 2021

Background: Pain and postoperative nausea and vomiting are the most common postoperative complications in middle ear surgeries. Amongst the beta-blockers, esmolol is ultrashort acting cardio selective β1 receptor antagonist used for management of postoperative pain. It also contributes to the significant decrease in PONV and reduces patient distress and facilitates earlier discharge. Objective: To evaluate the effectiveness of perioperative esmolol infusion on postoperative pain relief and postoperative nausea vomiting after middle ear surgeries. Methods: After obtaining approval from Institution Ethics Committee, 70 patients of age 15 and 65 years of ASA I,II and III were allocated with randomization into two groups of 35 each. Group C: 30 ml normal saline loading dose and thereafter continuous infusion of 1ml/min and Group E:0.5mg/kg esmolol in 30ml NS loading dose and 30ug/kg/min as infusion. Results: Average duration of analgesia was about 535 min in group E as compared to 187 min in group C. For PONV requirement of inj. ondansetron in group E was after 145 min and in group C it was 20 min. Group E patients had significantly less variations in blood pressure and heart rate intraoperatively and the response to intubation was masked as compared to group C. Conclusion: Intraoperative esmolol infusion is a newer justified method to reduce postoperative pain and PONV with advantage of hemodynamic stability.
A comparative study of post-operative analgesia after caesarean section with intrathecal hyperbaric bupivacaine combined with different doses of buprenorphine
Authors:   Department of Anesthesiology, RGSSH/Raichur Institute of Medical Sciences, Karnataka, INDIA., Angadi Veereshkumar
Published: August 2021

Background: Post-operative pain relief after caeserean section is challenging to both anesthetista and obstetricians. Injection buprenorphine can be used intrathecally for post operative analgesia. Aim: the aim of the study was to compare the efficacy of two different doses(30ug and 60ug) of buprenorphine intrathecally with hyperbaric bupivacaine for post operative pain relief in caserean section. Methods and Materials: A prospective randomised controlled study was done on 60 subjects undergoing elective casarean section where in two groups were made, Group A (n=30) and Group B (n=30) who received inj bupivacaine 0.5% hyperbaric 2ml plus inj buprenorphine 30ug and inj bupivacaine 0.5% hyperbric plus inj buprinorphine 60ug intrathecally respectively. Following parameters were observed, onset and duration of sensory block, postopertive pain measured on VAS(visual analogue scale),rescue analgesia requirement, maternal side effects. Results: Unpaired t test and Chi square test were used for statistical analysis. Duration of analgesia was longer significantly in group A compared to group B. rescue analgesia requirement and VAS were significantly lower in group A as compared to group B.No major side effects were seen. Conclusion: Increasing the dosage of buprenorphine intrathecally increased the duration and quality of post operative analgesia. with no major adverse effects.
Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021
Authors: Hobson Gemma , Adamson James , Adler Hugh , Firth Richard , Gould Susan , Houlihan Catherine , Johnson Christopher , Porter David , Rampling Tommy , Ratcliffe Libuse , Russell Katherine , Shankar Ananda Giri , Wingfield Tom
Published: August 2021

Most reported cases of human monkeypox occur in Central and West Africa, where the causing virus is endemic. We describe the identification and public health response to an imported case of West African monkeypox from Nigeria to the United Kingdom (UK) in May 2021. Secondary transmission from the index case occurred within the family to another adult and a toddler. Concurrent COVID-19-related control measures upon arrival and at the hospital, facilitated detection and limited the number of potential contacts.
An Exigency for Ice Core Studies to Determine Spatio-temporal Variability in Moisture Sources and Impact of Black Carbon – Mineral Aerosols on the Himalayan Glaciers
Authors: Ali Sheikh Nawaz , D. Shukla Anil
Published: August 2021

Himalayan glaciers‒ the store house of fresh water outside the polar region contributes ~45% of the total river flow by glacial melt in the Indus, Ganga and Brahmaputra watersheds which supports the livelihood of ~500 million people . The sustainability of these rivers is being questioned because of the growing evidences of accelerated glacier retreat in the recent decades, which is expected to have cascading effects on the mountainous areas and their surrounding lowlands. The rapid melting of Himalayan glaciers reveals their sensitivity to ongoing changes in climate dynamics, and if the current trend continues, rivers that rely heavily on snow/ice melt are expected to suffer hydrological disruptions to the point where some of the most populous areas may ‘run out of water’ during the dry season. Therefore, efforts are being made to study the glacier mass balance trends in order to understand the patterns and causes of recent recessional trend. Despite their importance, the absence of long-term mass-balance and remote sensing data restricts our knowledge of the Himalayan glaciers’ sensitivity/ response to climate change. Furthermore, such studies may be insufficient unless are compared to long-term glacier fluctuations (millennial and multi-millennial time scales), which aid in better understanding the natural trends of and human impacts on climate change, as well as assessing the causes and possible future of contemporary shrinking glaciers. This will also improve our understanding of past glacier behaviour in the context of primary causes of glacier change, which is critical for water resource management and understanding climate variability in high alpine areas where alternative proxy climate archives are typically scarce. Therefore, it is pertinent to pool our scientific resources and energy (i) towards understanding the Himalayan glaciers’ feeders (precipitation sources) and how they changed over time (geological and historical), as well as the causes of glaciers recession, one of which has been identified as (ii) black soot (carbon) in aerosol pollution.
A Review on the different studies on aromatherapy conducted in the Philippines
Authors: Joseph Mari B. Querequincia  , Erwin M. Faller
Published: August 2021

Aromatherapy has become prevalent in complementary and alternative medicine to treat ill conditions. The common substances utilized in this type of therapy are essential oils which contains odoriferous compounds. These substances can be directly applied or thru infusion in the closed environmental air. There are wide applications of aromatherapy from massage therapies up to its potential therapeutic utilizations. Across the globe in different countries, the custom of aromatherapy is gaining an acceptance in their respective health care systems. In the Philippines the use of aromatherapy is gaining its prominence to be an established complementary and alternative commodity. This article is focused to summarize the different published and available research information about aromatherapy conducted across the regions in the Philippines. This type of therapy is a prospective technique that could support customary health care procedures in treating diseases physiologically and psychologically in the Philippine health care setting.
Strategi Komunikasi Humas Satuan Polisi Pamong Praja Jambi Menjaga Ketertiban Pedagang Kaki Lima
Authors: Sartika  , Pirhat Abbas  , Nurhasanah  , Mardalina  , Muhsin Ruslan
Published: August 2021

Penelitian ini dilatarbelakangi oleh kurangnya kesadaran pedagang kaki lima untuk menjaga ketertiban, masih ada pedagang kaki lima Jalan Letjen Haryono Telanipura yang berjualan tidak sesuai dengan Peraturan mereka berjualan pada jam kerja antara pukul 06.00 s/d 16.00 WIB. Sebagai aparat Penegak Peraturan Daerah Satuan Polisi Pamong Praja dalam penyampaian informasi di bantu Humas dalam menyampaikannya. Dari persoalan tersebut mendorong penulis untuk melakukan penelitian untuk mengetahui Strategi KomunikasiHumas Satuan Polisi Pamong Praja dalam Menjaga Ketertiban Pedagang Kaki Lima Pendekatan Penelitian yang penulis gunakan adalah penelitian kualitatif. untuk menjelaskan apa yang terjadi secara lengkap, dengan menggunakan data primer dan skunder sebagai jenis data dan sumber data yang diperoleh melalui Humas (Kepala Satuan, Kasubag Umum dan Kepegawaian, Seksi Ketertiban Umum) dan Pedagang Kaki Lima di Kec. Telanaipura. Teknik pengumpulan data dilakukan melalui observasi, wawancara dan juga dokumentasi. Dari pengumpulan data tersebut dilakukan tiga analisis data yang berupa analisis data, yang berupa reduksi data dan dan vertifikasi data. Hasil penulis temukan bahwa Strategi Komunikasi Humas menjaga Ketertiban Pedagang Kaki Lima yaitu: komunikasi persuasif, komunikasi melalui surat dan  komunikasi sosialisasi.
Hubungan antara Penyesuaian Diri dengan Prestasi Akademik Mahasiswa
Authors: Abdullah Yunus  , Gita Erwilya
Published: August 2021

This article is motivated by the phenomenon of new students when they start entering college, the transition from high school to university brings up various social and academic changes that will be faced by students. The purpose of this study was to determine whether there is a relationship between self-adjustment and academic achievement of students of the da'wah faculty of the State Islamic University of Sultan Thaha Saifuddin Jambi. The research method used is multiple correlation, which is the method used to determine the relationship between one variable and another. The subjects in this study were 92 students of the Da'wah Faculty for the 2019 Academic Year. Based on the results of the research analysis, the correlation results were p = 0.005 0.005. The results obtained from the data analysis are Ho is rejected and Ha is accepted, so that the results show that there is a relationship between self-adjustment and academic achievement of students of the Da'wah Faculty of Sultan Thaha Saifuddin State Islamic University Jambi.
Experience and Performance of Tubeless Percutaneous Nephrolitotomy
Authors: Sergiychuk Roman
Published: August 2021

Percutaneous nephrolithotripsy is a standard method in the treatment of nephrolithiasis, in the final stage of which nephrostomy drainage is established, but there are known methods of performing this operation without nephrostomy.
This article shows our experience of performing tubeless percutaneous nephrolithotomy, as well as evaluates the safety and efficacy of tubeless PNL with placement of a JJ-stent.
The objective: establish opportunities to perform a tubeless mini percutaneous nephrolithotomy and evaluate the safety and effectiveness of its implementation.
Materials and methods. For the period 2017–2021. performed more than 500 percutaneous nephrolitotomy. 53 mini-PNL tubeless (II group), the other group (I group) included 58 patients who underwent mini-PNL by standard method. There were no significant differences in age and sex, location and size of stones in the study groups (p>0,05). All operations were performed under regional anesthesia.
Results. The average duration of the operation in group I was 57,2±17,9 minutes, in group II 54,9±15,6 minutes (p>0,05). The average drop of hemoglobin in I group was 0,39 g/l compared with 4,1 g/l in II group. The difference between the groups was not statistically significant (p>0,05). The level of pain in this study was assessed using a visual analog scale, in group I the average pain was 3,7 compared with 1,6 in patients of II group (p<0,05). Accordingly, the necessity of analgesia for I group was higher and amounted to 58,4±17,3 mg of dexketoprofen, against 27,3±15,2 mg of dexketoprofen in the second group (p<0,05).
Postoperative fever ≥38,0 °С was observed in 5 (8,6%) patients who performing the operation according to the standard method, and 1 (1,9%) of the patient (p>0,05) who performed drainage-free PNL. The stone free rate in I group was achieved in 56 (96,6%), in group II in 53 (100%) (p>0,05). The postoperative hospital stay in I group was 2,92±0,24 days, and in II group – 1,22±0,11 days (p>0,05). Analyzing the results of tubeless percutaneous nephrolithotomy, we can say that its effectiveness is due to careful selection of patients and strict compliance with the rules of PNL.
Conclusions. This study demonstrates the advantages of tubeless percutaneous nephrolithotomy over standard methods in the form of reducing the level of postoperative pain, according to the need for analgesics, and reduces the duration of postoperative hospital stay. However, it should be noted that drainage techniques of percutaneous nephrolithotomy should be performed in strictly selected patients.
PEMANFAATAN LIMBAH BETON SEBAGAI PENGGANTI AGREGAT KASAR PADA PERKERASAN LASTON ASPHALT CONCRETE – WEARING COARSE (AC-WC)
Authors: Imannurrohman Naufal
Published: August 2021

Meningkatnya pembangunan infrastruktur seperti gedung, jembatan, jalan, dan berbagai fasilitas publik lainnya yang banyak menggunakan bahan beton dapat mengakibatkan kerusakan lingkungan akibat limbah beton yang tidak dilakukan penanganan dengan serius. Untuk membatasi penggunaan agegat baru (fresh aggregate) dari alam ini sudah banyak dikembangkan teknologi daur ulang untuk perkerasan jalan. Tujuan penelitian ini untuk Mengetahui pengaruh limbah beton sebagai pengganti agregat kasar pada campuran laston (AC-WC) untuk perkerasan jalan raya terhadap nilai karakteristik marshall.

Penelitian ini menggunakan metode eksperimen dan pengujian marshall dengan percobaan serta perbandingan sesuai dengan kadar variasi limbah beton sebagai pengganti agregat kasar 0%, 10%, 15%, dan 20% dan variasi kadar aspal 5%, 5,5%, 6%, 6,5% sesuai Spesifikasi Bina Marga Revisi 3 (2010). Metode analisis data pada penelitian ini menggunakan analisis ANOVA (Analysis of Variance) satu arah.

Hasil yang didapat dari pengujian ini dihasilkan pengaruh nilai karakteristik marshall dengan kadar aspal optimum 6% menggunakan limbah beton optimum 15% yang berpengaruh baik terhadap nilai karakteristik marshall seperti nilai stabilitas sebesar 1869,30 kg, Flow sebesar 3,33 mm, VFB sebesar 76,97%, VMA sebesar 16,64 %, VIM sebesar 3,83% dan  MQ sebesar 590,97 kg/mm. Dengan demikian campuran tersebut sesuai dengan persyaratan Spesifikasi Teknis Bina Marga 2010, Revisi 3.
Peran Pembelajaran Musik melalui Project Based Learning terhadap Perilaku Sosial Anak Usia 5-6 Tahun
Authors: Ningrum Fitri Setyo , Safrina Rien , Sumadi Tjipto
Published: August 2021

Perilaku sosial merupakan salah satu aspek perkembangan yang penting untuk distimulus sejak usia dini. Melalui penelitian ini, peneliti menganalisa hasil temuan jurnal terkait dengan perilaku sosial anak dalam pembelajaran musik serta pendekatan project based learning terhadap perilaku sosial sebagai salah satu pendekatan yang pada anak usia dini. Penelitian ini merupakan penelitian studi pustaka/ literature dengan menggunakan buku, catatan hasil observasi serta penelitian terdahulu sebagai sumber data primer maupun sekunder. Berdasarkan hasil analisa penelitian, peneliti menemukan peranan pembelajaran musik berupa ansambel musik perkusi yang dapat digunakan sebagai salah satu aktivitas dalam meningkatkan perilaku sosial melalui sebuah pendekatan project based learning. Kegiatan ansambel musik perkusi serta pendekatan project based learning ini memberikan banyak kesempatan pada anak usia 5-6 tahun untuk berinteraksi, bekerjasama dengan teman lainnya, serta peduli dengan teman lainnya