bluuebunny/crossref_metadata_2025 huggingface dataset:
Dengue Fever Related Reactive Thrombocytosis in Young Male: A Case Report and Review Literature
Authors: Singh Jitendra , Dinkar Anju , Kumar Nilesh , Kumar Kailash , Vikrant
Published: September 2024

Introduction:

Dengue fever is prevalent in tropical nations, especially India. Leucopenia
and thrombocytopenia are distinctive features of acute dengue fever that revert to normal levels
after the patient's recovery. Dengue fever is associated with numerous unusual clinical manifestations
of different body systems. Additionally, the emergence of severe thrombocytosis following
thrombocytopenia is extremely rare. Based on our extensive knowledge, only three cases similar
to this have been documented in the literature.

Case Report:

Here, we present a case of a 36-year-old healthy man who had acute dengue and subsequently
developed severe reactive thrombocytosis. The patient was treated conservatively and
discharged. Subsequently, he developed thrombocytosis. Aspirin was given for a short period to
alleviate any potential repercussions.

Conclusion:

Thrombocytosis, a rare consequence of dengue infection, is usually asymptomatic.
Nevertheless, ongoing monitoring of dengue patients is required to avoid complications.
Improving linguistic competence through learning based on language error analysis and problems
Authors: Ana Haerun , Taembo Maulid , Konisi La Yani , Yunus Yunus
Published: September 2024

The success of an educational institution, especially those related to teaching, depends on various components, including materials and learning models or approaches. Materials and learning models or learning approaches must not only be able to attract students' attention but must also be following their needs and development. One learning model that pays attention to the needs and development of students is problem and error analysis-based learning. This learning model presents a real problem for students at the beginning of learning, then resolved through investigation and applied using a problem-solving approach. Therefore, the research "Improving Linguistic Competence through Learning Based on Language Error Analysis and Problems" is very interesting to be done immediately. This study aims to identify linguistic errors and problems found in everyday life and describe solutions to understand these problems in improving students' linguistic competence. The study of learning based on error and problem analysis can contribute to the development of linguistics, especially on linguistic problems that are still unsolved. In addition, the results of this study can contribute to the improvement and development of learning models based on error and problem analysis. This will help create a fun, challenging, and easy learning environment.
Morphisms and Algebraic Points on the Quotients of the Fermat Quintic
Authors: Fall Moussa
Published: September 2024

The purpose of this paper is to determine morphisms and algebraic points of low degree on the quotients of the Fermat quintic. An algebraic point of degree at most $3$ is called an algebraic point of low degree. The quotients of the Fermat quintic is a family curves $\mathcal{C}_{rs}(5) : v^5 =u^r(u-1)^s$ where $r$ and $s$ are integers such that: $1< r, s, r+s< 5$. We determine explicitly the morphisms between the curves $\mathcal{C}_{rs}(5)$. By applying Abel Jacobi's theorem and using Riemann-Roch spaces, we give a parametrization of algebraic points of low degree on the special curve $\mathcal{C}_{1,1}(5)$. Birational morphisms allow us to determine the set of algebraic points of low degree on each curve of the family curves $\mathcal{C}_{rs}(5)$.
Nuevos registros de babosas de cuero (Gastropoda: Veronicellidae) para Nuevo León, México, con un listado actualizado de las especies registradas en Norteamérica
Authors: De Luna Manuel , García-Barrios Roberto , Hernández-González Victor Alonso , Gámez-Cárdenas Abraham Israel
Published: September 2024

Se presentan nuevos registros de dos especies de babosas veronicélidas (Gastropoda: Veronicellidae) para Nuevo León, México: la babosa de terciopelo negro Belocaulus angustipes (Heynemann, 1885) y la babosa frijol Sarasinula plebeia (Fischer, 1868). Se actualiza el listado de babosas veronicélidas registradas para Norteamérica continental.
Identifying Potential Factors Associated With Racial Disparities in COVID-19 Outcomes: Retrospective Cohort Study Using Machine Learning on Real-World Data (Preprint)
Authors: Dasa Osama , Bai Chen , Sajdeya Ruba , Kimmel Stephen E , Pepine Carl J , Gurka J Matthew J , Laubenbacher Reinhard , Pearson Thomas A , Mardini Mamoun T
Published: September 2024

BACKGROUND

Racial disparities in COVID-19 incidence and outcomes have been widely reported. Non-Hispanic Black patients endured worse outcomes disproportionately compared with non-Hispanic White patients, but the epidemiological basis for these observations was complex and multifaceted.

OBJECTIVE

This study aimed to elucidate the potential reasons behind the worse outcomes of COVID-19 experienced by non-Hispanic Black patients compared with non-Hispanic White patients and how these variables interact using an explainable machine learning approach.

METHODS

In this retrospective cohort study, we examined 28,943 laboratory-confirmed COVID-19 cases from the OneFlorida Research Consortium’s data trust of health care recipients in Florida through April 28, 2021. We assessed the prevalence of pre-existing comorbid conditions, geo-socioeconomic factors, and health outcomes in the structured electronic health records of COVID-19 cases. The primary outcome was a composite of hospitalization, intensive care unit admission, and mortality at index admission. We developed and validated a machine learning model using Extreme Gradient Boosting to evaluate predictors of worse outcomes of COVID-19 and rank them by importance.

RESULTS

Compared to non-Hispanic White patients, non-Hispanic Blacks patients were younger, more likely to be uninsured, had a higher prevalence of emergency department and inpatient visits, and were in regions with higher area deprivation index rankings and pollutant concentrations. Non-Hispanic Black patients had the highest burden of comorbidities and rates of the primary outcome. Age was a key predictor in all models, ranking highest in non-Hispanic White patients. However, for non-Hispanic Black patients, congestive heart failure was a primary predictor. Other variables, such as food environment measures and air pollution indicators, also ranked high. By consolidating comorbidities into the Elixhauser Comorbidity Index, this became the top predictor, providing a comprehensive risk measure.

CONCLUSIONS

The study reveals that individual and geo-socioeconomic factors significantly influence the outcomes of COVID-19. It also highlights varying risk profiles among different racial groups. While these findings suggest potential disparities, further causal inference and statistical testing are needed to fully substantiate these observations. Recognizing these relationships is vital for creating effective, tailored interventions that reduce disparities and enhance health outcomes across all racial and socioeconomic groups.
Reflexões acerca da remediação no consumo de experiência na Comic Con Experience
Authors: Soares da Silva Leonardo
Published: September 2024

Based on the ethnography of the 2017, 2019, 2020 and 2021 editions of Comic Con Experience, an event held in São Paulo, this article relates remediation and experience consumption. Based on participant observation and 10 open and in-depth interviews, it identifies the concepts of collective and common imagination and voluntary suspension of disbelief, developing reflections that indicate that more than prior knowledge, experience consumption depends on an affective antecedence, formed through rituals that precede the event. Observing that throughout these rituals, addressed according to Jesus Martín-Barbero, remediations occur, a concept presented by Jay David Bolter and Richard Grusin, the article therefore considers that they contribute to experience consumption at the event.
Paola Ricaurte-Quijano: tecnologias digitais a partir de uma práxis política feminista
Authors: Júlia de Freitas Carrijo Ana , Carolina Damboriarena Escosteguy Ana
Published: September 2024

The interview conducted with researcher Paola Ricaurte-Quijano aims to present an account of her experience as a feminist researcher in the field of technologies, currently occupying an in-between academic and political South-North space, advocating for South demands. We address the researcher's trajectory, her political and academic choices, and her perspective on her current place of enunciation. We also discuss issues related to contemporary technologies, such as recommendation algorithms and datafication processes, emphasizing the contributions of a decolonial approach in this field.
Danske arbejdspladsers personalehåndtering under Covid-19 med særligt fokus på seniorarbejdskraften
Authors: H. Jensen Per , L. Andersen Lars , Nielsen Peter , Yogachandiran Qvist Jeevitha
Published: September 2024

Eksisterende forskning har allerede belyst, hvordan køns-, etniske og socioøkonomiske uligheder på arbejdsmarkedet er blevet forstærket under covid-19-pandemien. Denne artikel adskiller sig fra den eksisterende forskning derved, at fokus er på alder. Nærmere bestemt rettes blikket mod mulige aldersbetingede forskelle i arbejdsgivernes fastholdelses- og afskedigelsesmønstreunder covid-19-krisen. Teoretisk tager artiklen afsæt i de sociologiske segmenteringsteorier, og empirisk trækker vi på en arbejdspladssurvey, der er gennemført på cirka 5.000 danske arbejdspladser i perioden november 2020 til februar 2021(se SeniorArbejdsLiv.dk). De statistiske analyser viser, at arbejdspladsernes personalehåndtering og brug af støttepakker i høj grad har været betinget af arbejdspladsens økonomiske forhold, og i mindre grad de sociale forhold på arbejdspladserne. Undersøgelsen viser endvidere, at selvom støtteordningerne har fungeret som et bolværk mod afskedigelser, så har støtteordningerneikke forhindret afskedigelser. Blandt de afskedigede har vi yderligere fundet, at der ikke er markante uligheder i de aldersbetingede afskedigelser. På 13 % af arbejdspladserne har seniorerne været overrepræsenteret blandt de afskedigede, medens de 30-54-årige har været overrepræsenteret på 25 % af virksomhederne.
Rancangan Aplikasi E-Payment Restoran Sop Duren 97 berbasis Web dengan Implementasi Algoritma FCFS menggunakan React JS dan PostgresSQL
Authors: Ihsan Muhammad , Riyadi Agung Slamet , Wardhani Ire Puspa
Published: September 2024

Perkembangan teknologi informasi telah mengubah cara berinteraksi dan bertransaksi dalam bisnis, termasuk melalui platform online atau e-commerce. Banyak restoran masih menerapkan sistem pelayanan konvensional, yang dapat menimbulkan kendala saat pelanggan memesan makanan secara langsung. Hal ini berpotensi membuat pelayan menjadi kelelahan dan menghadapi kesulitan dalam pelayanan. Sebagai solusi, banyak bisnis restoran mengadopsi penggunaan QR Code untuk memesan makanan dan memfasilitasi pembayaran. Dalam konteks ini, penelitian ini bertujuan untuk mengimplementasikan aplikasi web E-Duren di Restoran Sop Duren 97 dengan mengintegrasikan teknologi payment gateway midtrans untuk memproses pembayaran. Sistem pesanan akan diatur menggunakan algoritma First Come First Serve (FCFS) guna meningkatkan efisiensi pelayanan dan memodernisasi pelayanan di restoran yang masih menggunakan metode konvensional. Hasil pengujian dari User Acceptance Test (UAT) dengan sampel 30 orang menunjukkan indeks persentase sebesar 83,1%, dengan kesimpulan bahwa aplikasi website E-Duren sudah berjalan lancar dan sesuai dengan kepuasan pengguna. Ujicoba aplikasi dengan blackbox testing untuk menguji fungsionalitas aplikasi untuk menunjukkan bahwa semua fungsi aplikasi telah berjalan lancar.
Transformasi Digital di Dunia Farmasi: Aplikasi Web untuk Pengelolaan Persediaan Obat di Apotek
Authors: Annisa Riski , Rahayuningsih Panny Agustia , Anna Anna , Fadilah Aldi
Published: September 2024

Transformasi digital telah membawa dampak signifikan pada berbagai sektor, termasuk dalam dunia farmasi. Penelitian ini mengusulkan dan mengimplementasikan aplikasi web untuk pengelolaan persediaan obat di apotek sebagai langkah menuju efisiensi dan inovasi dalam praktik farmasi. Aplikasi ini dirancang untuk memenuhi kebutuhan apoteker dan staf apotek dalam mengelola stok obat dengan lebih efektif. Pendekatan metodologi Waterfall diterapkan dalam pengembangan aplikasi, mulai dari perencanaan hingga implementasi dan evaluasi. Hasil penelitian menunjukkan bahwa aplikasi ini berhasil meningkatkan efisiensi pengelolaan persediaan obat dengan fitur-fitur seperti pemantauan stok real-time, notifikasi batas minimum, dan laporan persediaan yang akurat. Evaluasi fungsionalitas aplikasi dan analisis umpan balik pengguna mengindikasikan bahwa antarmuka pengguna yang intuitif dan navigasi yang mudah meningkatkan produktivitas apoteker. Dampak positif juga terlihat pada peningkatan kecepatan pelayanan kepada pelanggan dan pengurangan kekurangan stok obat. Dengan demikian, penelitian ini memberikan wawasan mendalam tentang dampak positif transformasi digital dalam pengelolaan persediaan obat di apotek melalui aplikasi web, sekaligus merinci kendala yang dihadapi. Implikasi hasil penelitian ini dapat memberikan kontribusi pada praktik farmasi yang lebih efisien dan berkelanjutan.
Rancang Bangun Sistem Informasi Inventaris pada Sekolah Berbasis web
Authors: Saputra Suwanda Aditya
Published: September 2024

Inventaris merupakan suatu aset dari suatu organisasi yang perlu dikelola dengan baik agar kegiatan operasional suatu organisasi dapat berjalan dengan baik pula. Kegiatan pada pengolahan data inventaris banyak dilakukan dengan cara pencatatan data barang serta pemberian identitas dari barang yang ada. Untuk mempermudah melakukan pencatatan ini diperlukan sebuah sistem yang dapat membantu dalam proses pengolahan data inventaris. Berbagai kebutuhan proses pengolahan transaksi harian, membantu dan mendukung seluruh kegiatan operasi, bersifat manajerial dari suatu organisasi dan membantu memperlancar penyediaan laporan yang dibutuhkan. Sistem infomasi inventaris merupakan sistem yang tepat dalam mempermudah melakukan proses inventarisasi barang pada suatu organisasi salah satunya ada di instansi sekolah. Dengan terdapatnya sistem informasi inventaris pada sekolah, hingga pengolahan informasi bisa dilakukan dengan efisien serta akurat. Sehingga tidak lagi terjalin kesusahan dalam pengolahan sistem informasi inventaris pada sekolah.
Rancangan UI/UX Emergency Button Pada Penanggulangan Situasi Darurat Menggunakan Metode Design Thinking
Authors: Noveandini Rahayu , Wulandari Maria Sri , Ramanda Galeh Putra
Published: September 2024

Saat terjadi keadaan darurat di Indonesia banyak kalangan masyarakat yang kurang paham bagaimana melakukan pertolongan pertama pada situasi darurat kemudian sosialisasi penanggulangan darurat masih kurang efektif sehingga banyak masyarakat yang tidak mengetahui bagaimana menghubungi petugas. Beberapa kalangan tertentu sudah mengetahui cara menghubungi petugas atau bahkan dapat melakukan pertolongan pertama pada saat terjadinya kedaan darurat seperti kecelakaan, bencana alam, kebakaran dan sebagainya. Namun tidak semua masyarakat mengetahui cara melakukan pertolongan pertama pada saat terjadi situasi darurat. Semakin lama keadaan darurat ditangani maka semakin banyak pula korban jiwa dan kerugian yang dialami oleh masyarakat. Agar dapat menyelesaikan masalah tersebut maka dibangun suatu rancangan UI/UX untuk Emergency Button pada penanggulangan situasi darurat yang dapat digunakan masyarakat sebagai sarana bantuan dalam mendapatkan pertolongan pertama secara lebih mudah dan efektif. Metode yang digunakan dalam pembuatan rancangan prototype aplikasi pertolongan darurat ini adalah menggunakan metode Design Thinking. Metode ini terdiri tahap emphatize, define, ideate, prototyping, dan testing. Hasil uji coba rancangan aplikasi ini menyatakan tingkat keberhasilan pengguna dalam mengerjakan tugas yang diberikan adalah 98%, dan hasil Single Ease Question dari skala 1 – 7 mendapatkan nilai 5,8 yang artinya aplikasi yang dibangun tidak sulit digunakan dan dapat diterima di masyarakat tetapi masih memerlukan sosialisasi dan adaptasi dalam penggunaannya.
Analisis Algoritma Apriori Untuk Mengidentifikasi Pola Penjualan Di Toko Sembako XYZ
Authors: Wulandari Dewi , Irawan Bambang , Bachtiar Agus
Published: September 2024

Abstrak - Dalam era perdagangan yang kompetitif, pemahaman mendalam tentang perilaku konsumen menjadi kunci utama bagi keberhasilan strategi penjualan sebuah toko. Penelitian ini berfokus pada analisis pola pembelian konsumen untuk mengidentifikasi barang yang sering dibeli secara bersamaan. Masalah utama yang dihadapi adalah kurangnya pemahaman mengenai kecenderungan konsumen dalam memilih produk secara bersamaan, yang menjadi landasan untuk mengoptimalkan strategi penjualan. Metode penelitian ini melibatkan analisis data transaksi dari riwayat penjualan perusahaan selama periode tertentu. Untuk menemukan pola pembelian yang signifikan, diterapkan algoritma Apriori, sebuah metode data mining yang efektif dalam mengidentifikasi asosiasi antara item-item dalam dataset transaksi. Proses ini melibatkan langkah-langkah analisis yang mendalam, termasuk pemrosesan data, identifikasi aturan asosiasi, dan interpretasi hasil untuk merinci pola pembelian yang relevan. Hasil penelitian menunjukkan bahwa sejumlah barang memiliki keterkaitan yang signifikan dalam pembelian bersamaan oleh konsumen. Barang-barang ini memiliki potensi untuk dioptimalkan melalui strategi penjualan yang mencakup bundling produk, promosi khusus, dan strategi tata letak produk. Implementasi strategi ini berpotensi meningkatkan volume penjualan dan memberikan dampak positif pada kinerja toko. Penelitian ini memberikan pandangan mendalam tentang perilaku pembelian konsumen dan menyajikan solusi praktis untuk meningkatkan strategi penjualan. Implikasi untuk pengambilan keputusan melibatkan pemberian rekomendasi kepada pemilik toko agar dapat merancang strategi penjualan yang lebih fleksibel dan responsif terhadap kecenderungan konsumen.
â€œOvercoming the Defectâ€:A Perinatal Review of Congenital Anomalies in 6984 Consecutive Deliveries in a Tertiary Care Center in Western Nepal
Authors: Aryal Shreyashi , Shrestha Deepak
Published: September 2024

Introduction: Neonatal congenital anomalies are the 17th leading cause of global disease burden. Congenital anomalies in low-income countries are high due to prevalence of nutritional deficiencies, intrauterine infections, teratogenic exposure and unsupervised self medication. This study aimed to find various antenatal risk factors for birth defects and the delays in health seeking behaviors in cases of still births with birth defects. Methods: In this retrospective study the records of mothers and neonates born with congenital anomalies during the period of 30 months were reviewed. Consanguinity, intrauterine infections, presence of anemia, and history of drug intake were noted. In cases of stillborns with anomalies, mode of delivery, labor complications and the three delays leading to morbidities were also noted. Results: There were 65 congenital anomalies during the study period with an incidence of 9.3 per 1000 births. Out of them, 43 were live births and 22 were still births. The commonest anomaly amongst live births was of musculoskeletal system (n=11, 25.5%) and amongst still births was of nervous system (n=10, 45.4%). Consanguineous marriage was present in 30 (46.1%) parents and folic acid was taken by only 26(40%) of the mothers. In cases of still births with anomalies, most deliveries were vaginal (97%) without any maternal complications. Among the three delays, delay in deciding to seek care was observed in most cases (n=14, 63.6%).Conclusion: Factors like consanguinity and intake of folic acid are modifiable factors useful in preventing congenital anomalies. Encouraging early antenatal visits might help in early detection of anomalies.
Morphometric Study of Lumbar Intervertebral Spaces (discs) by Using MRI.
Authors: Mansur Dil Islam , Shrestha Pragya , Maskey Sunima , Sharma Kalpana , Karki Subindra , Kisiju Trishna
Published: September 2024

Introduction: The radiological space between two vertebrae is known as intervertebral space (height) which corresponds to the thickness of the intervertebral disc. Lumbar intervertebral disc is the most important structure which maintains the spinal function. An early diagnosis of pathological changes in disc has clinical significance. Hence the study aimed to determine normal height of the intervertebral disc space and effect of aging. Methods: It was a cross-sectional analytical study performed on 106 images of MRI scans of lumbar region. Dimensions of lumbar intervertebral spaces (discs) such as the anterior, middle, posterior intervertebral space height were measured in millimeter. Results: The mean anterior intervertebral space height was gradually increased from L1-L2 level (6.91 mm) to L5-S1 level (13.55 mm). The middle intervertebral space height increased from L1-L2 level (7.89 mm) to L4-L5 level (11.96 mm) whereas at L5-S1 level, there was a decrease (11.10 mm). Similarly, the posterior intervertebral space height showed an increment from L1-L2 level (5.52 mm) to L4-L5 level (8.09 mm) except at L5-S1 level, where it was decreased (6.94 mm). All mean values were found to be higher in males than in females except posterior intervertebral space height. The height of disc was increased up to third or fourth decade followed by a decrease. Conclusion: Knowing the normal lumbar intervertebral space height could be helpful for clinicians to diagnose and plan for proper treatment. It may also help to generate baseline data and to produce proper devices for Nepalese population.
Hypertriglyceridemia Induced Acute Pancreatitis in Pregnancy: A Case Report
Authors: Subedi Anjali , Gurung Sonam
Published: September 2024

Introduction: Acute pancreatitis is a rare event in pregnancy. Hypertriglyceridemia induced acute pancreatitis accounts for the second most common cause in pregnancy. This rare event has a high maternal and fetal mortality of 20% and 50% respectively. Case report: A 21-year-old woman, G2P0+1 at 26 weeks period of gestation presented to OBGYN emergency in a state of shock with history of sudden onset of severe epigastric pain and multiple episodes of vomiting for one day and absent fetal movement for six hours. Immediate fluid resuscitation was done. Her reports showed increased hematocrit, leukocytosis, serum lipase and amylase elevated to > 200U/L. Ultrasonography showed bulky pancreas with intrauterine fetal death. With the diagnosis of acute pancreatitis with fetal demise, she was managed conservatively in intensive care unit by fasting, nasogastric aspiration, intravenous fluids, antibiotics, analgesics and heparin. She was intubated on the third day for increasing tachypnea. Her lipid profile showed elevated triglyceride> 1000 mg/dl and was started on oral hypolipidemic drugs. Pregnancy was terminated vaginally by misoprostol and was discharged on 19th day. Conclusion: Hypertriglyceridemia induced acute pancreatitis in pregnancy has an increased maternal and fetal complication.
COVID-19 Pandemic: An Unseenâ€™s Evolution War
Authors: Song Quek Yek , Ling Michelle Jia Ni
Published: September 2024

This is a new beginning. It started just like a fiction movie.In December 2019, a new cluster of pneumonia caused by the 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan, China. Without any mercy, it became a pandemic and left no time for grief. It was not only life-threatening but also challenged our healthcare system, economy, culture, lifestyle and belief. It forced us to make changes. We need to evolve, and we must evolve. Malaysia, a multi-ethnicity and multireligiouscountry which is located in Southeast Asia, has a population of 32 million with a median age of 28.9 years in 2019. According to the Observatory of Economic Complexity, Malaysia has experienced rapid globalization and is the 19th leading exporter in the world. It is an upper-middle-income country with a gross domestic product (GDP) of 370 billion USD in 2019, of which 4.5% is funded to the healthcare system.
Modern aspects of anti-viral therapy for hepatitis D
Authors: Zheleznova A. S. , Svirin K. A. , Kartashov M. Yu.
Published: September 2024

Viral hepatitis D (HDV infection) worsens the prognosis of HBV infection course in 80-90% of cases, accelerating fibrosis and leading to liver cirrhosis or hepatocellular carcinoma. Hepatitis D affects at least 125 000 people in Russia, and in the world, according to rough estimates, there are 15–20 million patients. The main measures to combat hepatitis D can be attributed to widespread scheduled vaccination against hepatitis B and the appointment of effective etiotropic therapy. A detailed study of the hepatitis D virus genome structure and its replication cycle allows the development of a number of drugs that target and block key mechanisms of the virus life cycle. This review provides a brief characterization of hepatitis D virus, its genome structure, key processes of its life cycle and mechanisms of genetic information realization. The review considers the main potential targets for targeted antiviral therapy of HDV infection and describes specific drugs (bulevirtide, lonafarnib, nucleic acid polymers). The review describes the mechanism of action of bulevirtide, which according to the current national clinical guidelines is a key element of antiviral therapy as monotherapy or in combination with pegylated interferons. Promising drugs affecting the processes of synthesis and post-translational modification of HDAg or reducing the production of surface proteins of hepatitis B virus are also considered. Further efforts are needed to develop safe, effective and cost-effective drugs against hepatitis D to ensure that treatment is widely available to those who desperately need it. Therefore, it is important that the life cycle of the hepatitis D virus be studied further, in greater detail, in order to develop highly effective antiviral drugs.
The phenomenon of viral chromosomal integration
Authors: Goleva O. V. , Cherkasova P. V. , Baziian E. V. , Igolkina A. A. , Ejsmont Yu. A. , Skripchenko N. V. , Chukhlovin A. B. , Glotov O. S.
Published: September 2024

The literature review is devoted to the chromosomally integrating viruses, the integration property. These are revealed using modern diagnostic methods, including highthroughput sequencing. The review describes various types of viruses, such as retroviruses, adenoviruses, herpes viruses, papillomaviruses, hepatitis B, SARS-CoV-2 and others. These viruses have the ability to integrate their genomes into the host cell genomes and their prevalence. Modern information on the molecular mechanisms of viral integration and methods of differential diagnostics is presented. Each of these viruses has its own unique ways of interacting with the host cell genome to maintain a latent state, which determines the specifics of the infectious process and pathological consequences for the body due to the possibility of effective reactivation.
Systemic meningococcal infection in children of the Arkhangelsk region: predictors of unfavorable course and outcome during different periods of observation
Authors: Samodova O. V. , Gordienko T. A. , Ivanova L. V. , Krieger E. A.
Published: September 2024

Invasive meningococcal infection remains a leading cause of death among infectious diseases in children.Aim. to investigate predictors of death in patients with invasive meningococcal infection during two periods of observation: 1991–2011 and 2012–2022.Materials and methods. A retrospective cohort study was conducted including 143 children aged 1,5 months to 17 years old, living in the Arkhangelsk region and having had invasive meningococcal infection. The study included two periods: 1991–2011 (N=93) and 2012–2022 (N=50). Groups of recovered and deceased patients were compared.Results. When admitted to the hospital meningococcal infection or bacterial meningitis was diagnosed in 25,5% of cases among deceased patients, and in 57,3% among survivors. More than half of the patients with an fatal outcome were not referred to the hospital after the first examination by a medical professional, unlike the recovered patients, of whom 68,8% were immediately referred to the hospital after examination. The majority of the recovered patients (82.3%) were transported to medical facilities providing specialized medical care. In the deceased group, treatment was initiated in non-specialized medical facilities in 74,5% of cases due to the distance from the regional center, where specialized care is provided. Throughout the observation period, the probability of death was higher in infants, patients with of septic shock, leukopenia, in cases requiring repeated visits by medical professional, and during initial therapy in nonspecialized medical organizations. Conclusion. The need to repeatedly seek healthcare, a different referral diagnosis, delays in receiving specialized medical care and the necessity for evacuation to the regional center for specialized care, all increase the probability of death and justify the advisability of specific prevention of meningococcal infection.
Significance of relative and absolute content of blood lymphocyte subopopulations for differential diagnosis of viral and bacterial meningitis in children
Authors: Zhirkov A. A. , Alekseeva L. A. , Bessonova T. V. , Zheleznikova G. F.
Published: September 2024

The search for markers of early etiological verification of meningitis is an urgent task for clinical laboratory diagnostics.Objective of the study is to determine the significance of relative and absolute content of blood lymphocyte subpopulations for early differential diagnosis of viral and bacterial meningitis in children.Materials and methods. There was performed a clinical and laboratory examination of 61 children, 37 of them were diagnosed with viral meningitis, and 24 ones – with bacterial purulent meningitis. The control group included 15 healthy children. The relative and absolute content of the main subpopulations (T-lymphocytes: T-helpers (Th), cytotoxic T-lymphocytes (CTL), NK, B-cells) and small subpopulations (NKT, DNT- and DPT-lymphocytes, CD3+CD8br, CD3+CD8dim, CD3-CD8+NK) of lymphocytes was assessed by flow cytometry. Statistical analysis of the data was carried out.Results. The decrease of relative and absolute content of all studied subpopulations was identified during an acute period of bacterial purulent meningitis, in comparison with the control group, with the exception of B-lymphocytes, the number of them was increased. Absolute content of all subpopulations was reduced in case of viral meningitis compared with the control group, the relative content did not have any significant differences, with the exception of an increase in the relative content of B-lymphocytes. Calculation of diagnostic sensitivity and specificity revealed the effectiveness of identification of both relative and absolute content of lymphocyte subpopulations for differential diagnosis of viral or bacterial meningitis. Identification of B-lymphocytes, NKT, CD3+CD8dim in the blood had the highest diagnostic efficiency (area under the ROC curve (AUC) ranging from 0,9 to 1).Conclusion. Assessment of relative and absolute content of blood lymphocyte subpopulations is an effective tool for laboratory differential diagnosis of viral and bacterial meningitis and can be used as an early differential diagnostic criterion, especially in case of impossibility to analyze the composition of cerebrospinal fluid.
Instruction to autor
Authors: Editorial Article
Published: September 2024

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Role of Sec61a2 translocon in insulin biosynthesis
Authors: Xu Xiaoxi , W. Bell Thomas , Le Truc , Zhao Ivy , Walker Emily , Wang Yiqing , Xu Ning , A. Soleimanpour Scott , A. Russ Holger , Qi Ling , Tsai Billy , Liu, Ming , Arvan Peter
Published: September 2024

Abstract

Translocational regulation of proinsulin biosynthesis in pancreatic b-cells is unknown, although several studies have reported an important accessory role for the Translocon-Associated Protein complex to assist preproinsulin delivery into the endoplasmic reticulum via the heterotrimeric Sec61 translocon (comprised of a, b, and g subunits). The actual protein-conducting channel is the a-subunit encoded either by Sec61A1 or its paralog Sec61A2. Although the underlying channel selectivity for preproinsulin translocation is unknown, almost all studies of Sec61a to date have focused on Sec61a1. There is currently no evidence to suggest that this gene product plays a major role in proinsulin production, whereas genome-wide association studies indicate linkage of Sec61A2 with diabetes. Here, we report that evolutionary differences in mouse preproinsulin signal peptides affect proinsulin biosynthesis. Moreover, we find that although some preproinsulin translocation can proceed through Sec61a1, Sec61a2 has a greater impact on proinsulin biosynthesis in pancreatic b-cells. Remarkably, Sec61a2-translocon deficiency exerts a significant inhibitory effect on the biosynthesis of preproinsulin itself, including a disproportionate increase of full-length nacent chain unreleased from ribosomes. This study not only reveals novel translocational regulation of proinsulin biosynthesis, but also provides a rationale for genetic evidence suggesting an important role of Sec61a2 in maintaining blood glucose homeostasis.

Article Highlights

· Preproinsulin uses its signal peptide to engage the Sec61 translocon, but surprisingly, existing data show no appreciable insulin biosynthesis or diabetes phenotypes linked to the Sec61A1 gene.

· We wanted to know if Sec61a2 might contribute to insulin biosynthesis, because GWAS links Sec61A2 (the unstudied paralog of Sec61A1) to T2D.

· We found a major drop in proinsulin biosynthesis in b-cells deficient for Sec61a2 (much more than for Sec61a1) and further, this reflexively inhibits preproinsulin translation.

Our data suggest that the genetic linkage of Sec61A2 to T2D may be explained by a defect in insulin biosynthesis.
Factors associated with oral intake ability in patients with acute-stage stroke
Authors: Ikegami Toshiyuki , Kobayashi Mika , Matsumoto Shuji
Published: September 2024

Objective: To investigate the factors predicting oral feeding ability following acute stroke.
Methods: This retrospective study compared patients admitted to a stroke care unit in 2 groups: an oral intake group and a tube feeding group. The groups were evaluated for 28 items and initial blood investigation tests, and the results compared. Logistic regression analysis was used to identify the clinical variables significantly associated with oral feeding ability.
Results: A total of 255 stroke patients (162 in the oral intake group and 93 in the tube feeding group) were admitted to the stroke care unit. Significant differences were observed between the 2 groups for 20 items. Logistic analysis found that the following variables were significant in the prediction model: age, date of initiation of oral feeding, stroke recurrence/patient deterioration during hospitalization, and date of initiation of occupational therapy.
Conclusion: Factors associated with achieving oral intake among stroke care unit patients were: young age at time of admission; starting oral intake early; no stroke recurrence/patient deterioration during hospitalization; and achieving rehabilitation of daily activities early during the physical function recovery stage.
Memorias del archipiélago: Efectos de las especies invasoras en las islas Galápagos. Evaluación de riesgo y soluciones actuales
Authors:   Escuela Superior Politécnica de Chimborazo Ecuador, Guala Alulema Paola , Monar Nuñez Joel ,   Escuela Superior Politécnica de Chimborazo Ecuador, Vásquez García Mirella Noemí ,   Unidad Educativa José Joaquín de Olmedo, Bachillerato Técnico, Shushufindi 210401, Ecuador., Guamán Coronel María de los Ángeles ,   Universidad Técnica particular de Loja (UTPL) Ecuador, Paredes Vargas Mirian Janeth ,   Unidad Educativa José Joaquín de Olmedo Ecuador
Published: September 2024

El archipiélago de Galápagos es una de las áreas protegidas más sobresalientes de Ecuador. En 1978 fueron declaradas Patrimonio Natural de la Humanidad por la UNESCO. Galápagos consta de 234 islas, entre ellas, 15 grandes, varios islotes y rocas pequeñas. Su superficie total es de aprox. 8000 km 2. Están ubicadas a 930 km de la costa de Ecuador en el Océano Pacífico. Posee gran biodiversidad, cerca de 7000 especies identificadas. Acoge a más de 271238 turistas. Es un atractivo turístico con varias actividades por desarrollar, entre ellos, senderismo por la playa, visita a sus volcanes, surf, natación etc. Además, existen varios centros de investigación educativa. Sin embargo, desde su descubrimiento en 1535 ha sufrido un terrible mal, denominado “ser humano” el cual es el responsable de introducir especies ajenas al ecosistema insular. Estas especies ocasionan grandes perjuicios hacia el medio ambiente, atentan con la salud de las personas y en contra de las especies endémicas del lugar. Por esta razón, es importante conocer su historia a lo largo del tiempo, para comprender como fue llegando dichas especies. En este sentido, se han establecido tres objetivos que se cumplen a cabalidad. Cada uno de ellos fue resuelto mediante revisión de literatura en bases de datos científicas a través de la web. El primero objetivo es diagnosticar la historia del surgimiento de las especies exóticas en Galápagos, en la cual, se estima que aparecieron por acciones antrópicas, como, trasporte o comercio en el año de 1807, para el año de 1971 el número de especies oscilaban los 77 ejemplares, desde entonces el número continua creciendo hasta la fecha, existe un aproximado de 1579 especies invasoras en la actualidad. El según objetivo conlleva determinar los principales efectos que ocasionan las especies invasoras sobre el archipiélago de galápagos, en la cual, afectan el equilibrio ecosistémico de la región insular, desplazan y compiten con las especies endémicas, disminuyen la cantidad de nutrientes y modifican la estructura natural del suelo, sobre todo tienen el potencial de erradicar o extinguir gran parte de las especies endémicas de las islas Galápagos. Por último, las alternativas para el control y erradicación de las especies exóticas conllevan alianzas activas con organizaciones nacionales e internacionales, con el fin de buscar apoyo financiero para obtener herramientas adecuadas para el manejo y monitoreo de las especies invasoras dentro de Galápagos.
Activity Theory as Theoretical Framework for Analyzing and Designing Global K-12 Collaborations in Engineering: A Case Study of a Thai-U.S. Elementary Engineering Project
Authors:   Texas Tech University, Hite Rebecca , Thompson Christopher ,   Texas Tech University
Published: September 2024

The American engineering pipeline requires future workers to possess a unique skill set, comprised of content knowledge and 21st century skills, to recruit highly skilled, globally competitive engineers. Generally, 21st century skills are defined as the ability to think critically, communicate, collaborate in teams, and creatively solve problems. These skills are pertinent in training future engineers provided engineering utilizes the application of scientific knowledge within an inherently collaborative modality (the engineering design process). One component of developing 21st century skills and engineering competencies is the need for students to broaden their global awareness. Hence, American K-12 teachers are actively seeking opportunities for their students to collaborate with their international peers in an engineering context. One emergent pedagogical strategy is engaging in global K-12 collaborations in engineering in which K-12 students collaborate with international counterparts (another K-12 classroom/s or engineering expert/s), using the engineering design process, to create collaborative engineering solutions (projects). Because of the social complexity of global K-12 collaborations in engineering, the efficacy of these endeavors varies. This paper proposes Activity theory (AT) as a theoretical framework to analyze global K-12 collaborations in engineering. The authors use AT, in the context of an elementary-level U.S./Thai global collaboration, to document the experience and describe the activity. Using student, teacher, and expert created documents from the collaboration, the efficacy of the activity (student learning outcomes) were evaluated and then applied to AT. The rules, division of labor and community were found as areas that presented challenges to achieving successful outcomes within the activity system. This paper provides classroom teachers a roadmap for designing more successful global collaborations for K-12 engineering and 21st century skill development.
Epidemiology of Lumpy Skin Disease in Ethiopia: Review
Authors: TT* Gemechis
Published: September 2024

Lumpy skin disease virus (LSDV) is responsible for causing Lumpy skin disease (LSD) in cattle and buffalo. Its origins trace back to Zambia in 1929, with the first recorded case of LSDV infection reported in that year. Subsequently, the virus spread to Ethiopia, which was identified in the North-West region in 1983. LSD primarily affects cattle and buffalo, causing symptoms such as fever, depression, and enlarged lymph nodes. The disease is more severe in young and female animals. LSDV is mainly transmitted by stable flies, mosquitoes, and ticks. In Ethiopia, the disease is more prevalent in the midland agro-climate zone. LSD has significant economic impacts, reducing productivity and causing deaths in affected animals. Measures such as quarantine, vaccination, and slaughter campaigns are implemented to control and prevent the disease. In countries where the disease is new, infected animals and those in contact with them should be removed to prevent its spread. Vaccination is the main approach to controlling the disease in endemic countries like Ethiopia.
problematização dos evangélicos e do “bolsonarismo” na literatura científica francesa
Authors: Arêas Camila Cabral
Published: September 2024

Com o objetivo de abordar a relação entre religião e politica no Brasil, no contexto do governo de Jair Bolsonaro (2019-2022), o presente artigo traça um panorama da produção cientifica francesa sobre o tema de modo a evidenciar os enfoques e argumentos-chave da problematização da questão dos “evangélicos e o bolsonarismo” nesta literatura. Inscrito nas Ciências da Informação-Comunicação, o estudo delineia uma cartografia disciplinar e temática do tema, analisa os principais postulados da problematização cientifica e, por fim, propõe uma analise programática da relação entre religião e partidos políticos. Se a cartografia elaborada configura um campo interdisciplinar de artigos sobre o tema, a perspectiva programática proposta, assente na ciência politica, permite interrogar uma problemática essencial deste campo de estudo: a definição da relação que liga, articula, separa ou hierarquiza o religioso e o politico. O presente estudo visa assim contribuir à reflexão sobre os usos do secular e do religioso no campo político por meio da analise do problema da “sacralização do religioso” e da “secularização do religioso”, adaptada ao estudo de caso brasileiro.
Homofobia cristã e conservadorismo político
Authors: Silva Ana Rosa Cloclet da , Buttignol Fernando César
Published: September 2024

Esse artigo tem como objetivo descrever e analisar a atuação discursiva de um conjunto de lideranças e ministérios que compuseram a recém-extinta organização cristã interdenominacional Exodus Brasil, cujo trabalho foi tradicionalmente justificado pelo suposto objetivo de levar alívio emocional para pessoas cristãs em conflito com a homossexualidade, por meio da conversão religiosa. Com base no monitoramento digital e na análise discursiva das posturas teológicas e políticas, tendo como cenário o governo de Jair Bolsonaro (2019-2022), busca-se analisar as representações sobre a homossexualidade construídas nas redes digitais Facebook e Instagram, de modo a comprovar a hipótese de que se configuram em expressões de homofobia religiosa, cuja visibilidade social foi favorecida pelo contexto mais amplo de conservadorismo político vivenciado pelo país nos últimos anos. Sob tal ênfase, os resultados atingidos agregam elementos teóricos e empíricos para a discussão sobre o trânsito entre religião e política no Brasil, protagonizado por novos atores e suas estratégias de atuação.
Ciência da religião no Brasil
Authors: Senra Flávio , Castro Leandro Evangelista Silva , Bertante Rafael
Published: September 2024

O presente artigo objetiva apresentar elementos da constituição histórica e uma problematização sobre perfis epistemológicos presentes nas três primeiras décadas da disciplina Ciência da Religião no Brasil. O trabalho identifica, comparativamente, as complexas interrelações político-acadêmicas havidas nesse período de constituição da disciplina, e problematiza as repercussões que esse histórico e perfis representam para o desenvolvimento dos estudos científico-acadêmicos sobre religião no país. Metodologicamente, o texto foi construído a partir de análise documental de atas, publicações e projetos pedagógicos da criação dos cursos da UFJF, PUC SP e UMESP. Sob a confluência de interesses eclesiais, teológicos e sociais, com reduzida autocompreensão do seu perfil teórico-metodológico, a disciplina Ciência da Religião emerge no cenário acadêmico nacional na segunda metade do século XX.
neopentecostalismo é neoliberal?
Authors: Cintra Paula Lobo
Published: September 2024

A mentalidade neoliberal atinge todas as áreas da vida dos indivíduos. O sagrado não fica à margem do processo de materialização, individualização e mercantilização que ela propõe. Atrelado à naturalização desta racionalidade no Brasil, um fenômeno ocorre: o aumento de um ramo religioso em projeções alarmantes. Este cenário faz surgir questionamentos quanto à existência de relação entre a política neoliberal e esta vertente religiosa cristã, os chamados: neopentecostais. Para a análise do tema serão feitas breves considerações sobre a origem do neopentecostalismo no país, seguidas de indagações quanto à possibilidade de entender o fenômeno vinculado a uma perspectiva neoliberal. Para tanto, a pesquisa põe em debate: a aproximação das organizações aos imperativos empresariais; a economização do sagrado traduzida na mercantilização e uso de linguagem publicitária; a emancipação do sujeito religioso da solidariedade social típica de ajuntamentos religiosos; e o sacrifício do sujeito pela organização unida à responsabilização pelo seu insucesso pessoal. Por fim, será realizada uma ponderação sobre a política brasileira e a presença de lideranças neopentecostais na atualidade. Neste objetivo, foi determinado o método hermenêutico-argumentativo, além das pesquisas exploratória e bibliográfica, valendo-se, como procedimentos técnicos, da documentação indireta.
pensamento neoliberal no discurso religioso
Authors: Santos Ana Maria
Published: September 2024

Este trabalho explora a aproximação do discurso da Igreja Universal em Portugal, durante a crise financeira e o programa de austeridade, ao pensamento político neoliberal, recorrendo à centralidade do conceito de empreendedorismo na retórica de ambos. Analisa-se a produção escrita da Universal no seu jornal Folha de Portugal entre os anos 2010 e 2012, pesquisando todas as referências a empreendedorismo e conceitos relacionados, fazendo a análise do discurso. Os dados recolhidos apontam para uma sobrevalorização do empreendedorismo como solução para a crise, relativizando os constrangimentos provocados pela crise e austeridade e, assim, para o alinhamento com a ideologia e habitus neoliberal.
Por uma teologia situada...
Authors: De Souza Glaucio A.F.
Published: September 2024

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