bluuebunny/crossref_metadata_2025 huggingface dataset:
A Meta-Analysis of Risk Markers for Intimate Partner Violence in Same-Sex Relationships
Authors: Kimmes Jonathan G. , Mallory Allen B. , Spencer Chelsea , Beck Austin R. , Cafferky Bryan , Stith Sandra M.
Published: May 2017

Research on intimate partner violence (IPV) has largely focused on heterosexual relationships, but, in recent years, researchers have expanded their focus to include same-sex relationships. Using meta-analytic techniques, this study was conducted to examine the relative strength of various risk markers for men and women being perpetrators and victims of physical IPV in same-sex relationships. Articles were identified through research search engines and screened to identify articles fitting the inclusion criteria, a process that resulted in 24 studies and 114 effect sizes for the meta-analysis. The strongest risk marker among those with at least two effect sizes for both male and female perpetration was psychological abuse perpetration. The strongest risk marker among those with at least two effect sizes for IPV victimization was also perpetration of psychological abuse for males and psychological abuse victimization for females. Among same-sex-specific risk markers, internalized homophobia and fusion were the strongest predictors for being perpetrators of IPV for men and women, respectively. HIV status and internalized homophobia were the strongest risk markers for IPV victimization for men and women, respectively. Of 10 comparisons between men and women in risk markers for IPV perpetration and victimization, only 1 significant difference was found. The results suggest that although same-sex and heterosexual relationships may share a number of risk markers for IPV, there are risk markers for physical IPV unique to same-sex relationships. Further research and increased specificity in measurement are needed to better study and understand the influence of same-sex-specific risk markers for IPV.
The Relationship Between Childhood Maltreatment and Violence to Others in Individuals With Psychosis: A Systematic Review and Meta-Analysis
Authors: Green Kathleen , Browne Kevin , Chou Shihning
Published: May 2017

Background:

There is a growing body of literature identifying a relationship between experiences of child abuse and symptoms of psychosis in adults. However, the impact of this relationship on risk of violence has not been systematically explored.

Aims:

This meta-analysis aimed to consider the influence of childhood abuse on the risk of violence among individuals with psychosis.

Method:

Five bibliographic databases and two gray literature resources were systematically searched to identify quantitative research which measured risk of violence and experiences of childhood maltreatment in individuals with psychosis. Risk of bias for each study was assessed under predefined criteria. Logged odds ratios ( OR) were synthesized quantitatively in a meta-analysis.

Results:

A total of 6,298 studies were identified, 11 of which were included in the final analysis ( N = 2,215), all studies were of a cross-sectional or case-control design. Individuals with psychotic illnesses who reported historical child maltreatment were at approximately twice the risk of perpetrating violence than patients who reported no early abuse, OR = 2.46, 95% confidence interval (CI) = [1.91, 3.16]. There was no statistical heterogeneity between main effects (τ = .00; χ2 = 8.87, df = 10, p = .54, I 2 = 0%).

Discussion:

Risk assessments and interventions may benefit from considering the unique contribution of trauma to violence in this population. Future research considering the interaction between childhood experiences and other risk factors for violence in this population, including specific symptoms of psychosis, would inform the current findings. Findings are limited by the lack of longitudinal research in this area, and there was some evidence of publication bias.
Views on Exercise
Authors: Shaw Michele Rose , Katz Janet , Benavides-Vaello Sandra , Oneal Gail , Holliday Carrie
Published: May 2017

Introduction:

There is a large prevalence of asthma, particularly among Hispanic children. Although physical activity is a good way to manage asthma, more Hispanic children with asthma lack activity than their healthy classmates. Given this, the purpose of this study was to explore the development of exercise perceptions in Hispanic children with asthma and to further develop an existing explanatory theory.

Method:

Grounded theory was the approach for the study. Grounded theory illuminated components of exercise perceptions from participants. Participants included Hispanic children with asthma, their families, and professionals who work with Hispanic children with asthma ( n = 29).

Results:

Findings from this study supported the previously identified grounded theory called The Process of Creating Perceptions of Exercise. In addition, two new concepts ( cultural and peer influences) were identified that further explain the category of exercise influences.

Conclusion:

The revised theory can be used to assist in developing nursing interventions aimed at increasing exercise participation among Hispanic children with asthma.
Evidence-Informed Primary Bereavement Care: A Study Protocol of a Knowledge-to-Action Approach for Systems Change
Authors: Lang Ariella , Fleiszer Andrea R. , Duhamel Fabie , Aston Megan , Carr Tracy , Goodwin Sharon
Published: May 2017

Using a systems change approach to knowledge-to-action, the purpose of this study is to increase organizational and practitioner uptake of an evidence-informed primary bereavement care guideline in home and community care through a researcher-knowledge-user partnership. Guided by the Consolidated Framework for Implementation Research, a single case study design will be used to examine system change in its natural context. The project integrates an organizational change initiative and a research study. Multiple data collection and analysis strategies will be used to explore and map the interactive synergistic process of interconnected decisions and actions. Iterative cycles of analysis and feedback will incite knowledge-user reflection and action, shape and substantiate findings, use data in a timely fashion to inform and guide next steps, and ensure ongoing monitoring and evaluation of the process.
Pretesting Qualitative Data Collection Procedures to Facilitate Methodological Adherence and Team Building in Nigeria
Authors: Hurst Samantha , Arulogun Oyedunni S. , Owolabi Mayowa O. , Akinyemi Rufus , Uvere Ezinne , Warth Stephanie , Ovbiagele Bruce
Published: May 2017

Qualitative methods are becoming widely used and increasingly accepted in biomedical research involving teams formed by experts from developing and developed practice environments. Resources are rare in offering guidance on how to surmount challenges of team integration and resolution of complicated logistical issues in a global setting. In this article we present a critical reflection of lessons learned and necessary steps taken to achieve methodological coherence and international team synergy. A series of 10 pretest interviews were conducted to assess instrumentation rigor and formulate measures to address any limitations or threats to bias and management procedures before carrying out the formal phase of qualitative research, contributing to an evidence-based stroke-preventive care clinical trial study. The experience of pretesting notably helped to identify obstacles and thus increase the methodological and social reliability central to conducting credible qualitative research, while also ensuring both personal and professional fulfillment of our team members.
Current Mixed Methods Practices in Qualitative Research: A Content Analysis of Leading Journals
Authors: Archibald Mandy M. , Radil Amanda I. , Zhang Xiaozhou , Hanson William E.
Published: May 2017

Mixed methods research (MMR) has become increasingly popular in recent years. Yet, methodological challenges of mixing qualitative and quantitative data remain. Understanding how MMR is approached in qualitative research journals provides insights into lingering mixing issues. In this article, we content analyzed five leading qualitative research journals from 2003 to 2014, which represents the reflective period of MMR. Of the 5,254 articles published, 94, or 1.79%, were mixed methods in nature, comprising 44 theoretically oriented articles and 50 empirical articles. In terms of theoretical articles, five content-based themes were identified: (a) MMR advocacy, (b) philosophy issues, (c) procedural suggestions, (d) practical issues and best practices, and (e) future directions. In terms of empirical articles, 36% used exploratory sequential designs, primarily to develop instruments, and 52% explicitly identified as MMR. None of the studies included MMR questions, and development (21%) and complementarity (14%) were the primary rationales for mixing. In virtually all studies (98%), mixing occurred at the data interpretation stage through some comparison of qualitative and quantitative research. Qualitative data were prioritized in 86% of the studies. Based on these findings, it appears that MMR affects qualitative research most directly by influencing study design and study purpose; however, there is a strong tendency to conduct and publish qualitative and quantitative studies separately. Recommendations for publishing future MMR are discussed.
Combining Qualitative and Quantitative Data Collection and Analysis Methods in Understanding Multiple Sclerosis Fatigue Management
Authors: Thy Merrill J. Turpin B.Occ. , Asano Miho , Finlayson Marcia
Published: May 2017

Combining qualitative inquiry with quantitative frequency data in a mixed methods research approach was valuable in understanding the strategies that people with Multiple Sclerosis (MS) used to manage their fatigue. Understanding its management is important because fatigue is often described by people with MS as their most disabling symptom and can pervade all aspects of a person's life. This research aimed to identify how often people used particular fatigue management strategies and the factors that influenced their use in the context of daily life. The methodology was Qualitative Description with phenomenological overtones using convenience sampling, interviews with semi-structured and structured components, and frequencies combined with typology development. Thirty-one people with MS from Chicago, Ill and Brisbane, Queensland in Australia who experienced fatigue were interviewed and asked to sort 15 cards with common fatigue management strategies into 3 categories, indicating whether they used them regularly, sometimes or never. Frequency counts were used to identify the number of participants who placed a specific strategy in a particular category. Frequencies were used to develop a typology with which to code the qualitative data. The strategies placed most frequently in each category were: Plan / organize the day used regularly, Ask someone for help used sometimes, and Use mobility devices never used. Mixed methods research techniques enabled us to explore the participants' fatigue management in greater depth. Each data type (i.e., qualitative and quantitative data) complemented the other and led to a richer understanding than either could provide in isolation.
Applying a Transdisciplinary Mixed Methods Research Design to Explore Sustainable Diets in Rural South Africa
Authors: Claasen Nicole , Covic Namukolo M. , Idsardi Ernst F. , Sandham Luke A. , Gildenhuys Anél , Lemke Stefanie
Published: May 2017

This article describes a conceptual framework for exploring sustainable diets, using a case study example of ongoing research in the Vaalharts region, a rural setting in South Africa. A qualitative research approach is followed with an integrated transdisciplinary mixed methods research design with multiple concurrent components employed during two sequential phases. A successful application of the framework is achieved through a collaborative team effort of researchers with qualitative and quantitative research expertise transcending different disciplines, as well as participation of community members throughout the research process. We demonstrate that transdisciplinary mixed methods research designs are essential to gain a better understanding of the complex concept of sustainable diets.
Transformational Grounded Theory: Theory, Voice, and Action
Authors: Redman-MacLaren Michelle , Mills Jane
Published: May 2017

Grounded theory has been evolving methodologically since Barney Glaser and Anselm Strauss first described it in the late 1960s. Initially underpinned by modernist philosophy, grounded theory has had recent turns including the adoption of both constructivism and postmodernism. This article explores ontological offerings of critical realism as a basis for transformational grounded theory informed by participatory action research and decolonizing research methodologies. The potential for both theory and action to result from this critical grounded theory methodology, which promotes greater participation and equity of power for positive change, is the transformational in transformational grounded theory.
Event-making the past: Commemorations as social movement catalysts
Authors: Jerne Christina
Published: May 2017

While shared narratives of the past have long been considered functional in terms of legitimising, coordinating and directing movement imaginary and action, it is not until recently that studies of memory and social movements have begun to interact systematically. Furthermore, these studies have treated mnemonic practices from a cognitive perspective rather than an affective, relational stance. This article analyses the mass commemoration of mafia victims that took place in Bologna on 21 March 2015 using an affective lens. It shifts the focus from memory as an identity-shaping, community-building force to memory as a mobilising force that intensifies and fuels heterogeneous and multidirectional movements such as the anti-mafia. In particular, it highlights the suggestive force of objects, discourses and bodies that together catalyse the crowd, drawing from ethnographic material. It concludes that what is ritualised, and thus important for the movement’s direction, is the way the past is presented and lived through the event. It suggests that the study of social movements and memory can benefit from the affective turn in memory studies.
Relationships Between Knee Extension Moments During Weighted and Unweighted Gait and Strength Measures That Predict Knee Moments After ACL Reconstruction
Authors: Hartigan Erin , Aucoin Jennifer , Carlson Rita , Klieber-Kusak Melanie , Murray Thomas , Shaw Bernadette , Lawrence Michael
Published: May 2017

Background:

Weighted gait increases internal knee extension moment impulses (KEMI) in the anterior cruciate ligament–reconstructed (ACLR) limb; however, limb differences persist.

Hypotheses:

(1) KEMI during normal gait will influence KEMI during weighted gait and (2) peak knee extension (PKE) torque and time to reach PKE torque will predict KEMI during gait tasks.

Study Design:

Descriptive laboratory study.

Methods:

Twenty-four women and 14 men completed 3 gait tasks (unweighted, vest, sled) and strength testing after discharge from rehabilitation and clearance to return to sports. KEMI were calculated during the first 25% of stance. PKE torque and time to reach PKE torque were obtained using a dynamometer. Data on the ACLR limb and symmetry indices (SIs) were analyzed for each sex.

Results:

Women presented with asymmetrical PKE torques and KEMI across tasks. There were three correlations noted for KEMI: between the walk and vest, walk and sled, and vest and sled tasks. Slower time to PKE torque predicted limb asymmetries across tasks and KEMI in the ACLR limb during the sled task. Men presented with asymmetrical PKE torques and KEMI during the sled task. There was a correlation noted for KEMI between walk and vest tasks only. During the sled task, ACLR limb time to PKE torque predicted KEMI in the ACLR limb and PKE torque SI predicted KEMI SI.

Conclusion:

Women use asymmetrical KEMI profiles during all gait tasks, and those with worse KEMI during walking have worse KEMI during weighted gait. Men have asymmetrical KEMI when sled towing, and these KEMIs do not correlate with KEMI during walking or vest tasks.

Clinical Relevance:

PKE torque deficits persist when attempting to return to sports. Only men use gains in PKE torque to improve KEMI profiles. Although quicker PKE torque generation will increase KEMI in women, normalization of KEMI profiles will not occur by increasing rate of force development only. Gait retraining is recommended to correct asymmetrical KEMI profiles used across gait tasks in women.
Catheter-free nephrectomy: A safe change to routine practice
Authors: Zimmermann EF , Dutton TJ , Crundwell MC
Published: May 2017

Background:

British Association of Urological Surgeons (BAUS) published updated guidance on the Enhanced Recovery Programme (ERP) in December 2015 to include avoidance of routine catheterisation and drain insertion in minimally invasive nephrectomy. We changed our practice to ‘catheter-free’ nephrectomy and present a retrospective comparative study of the outcomes in support of this guideline.

Aim:

The aim of this article is to assess any difference in length of stay (LOS), complications and readmission rates between patients who had catheter-free nephrectomy compared to those who had a catheter inserted as routine peri-operatively.

Method:

Catheter-free nephrectomy was implemented in May 2014. A retrospective comparative case note review was performed for all eligible patients from January 2013 until May 2015. All partial and radical nephrectomies (laparoscopic or robotic) were included, regardless of pathology.

Results:

Ninety-two patients were included. Of these, 45 patients had a routine catheter inserted peri-operatively (17 partial, 8 simple, 20 radical), and 47 patients had a catheter-free nephrectomy (22 partial, 2 simple, 23 radical). Mean age difference between groups was non-significant (61.0 vs 60.3 years, p = 0.82). LOS was longer in the catheter group compared to catheter-free group (mean 3.85 vs 2.53 days, median 3 vs 2 days, respectively, p = 0.029). There were 13 complications in the catheter group, two of which were complicated urinary tract infections, causing one readmission. In the catheter-free group there were six postoperative complications and no readmissions; three patients went into acute urinary retention requiring either short-term intermittent self-catheterisation or ‘in/out’ catheterisation. None of these patients were discharged with a catheter.

Conclusion:

Nephrectomy without routine insertion of a catheter appears to be safe and was associated with a shorter hospital stay and no increase in complications, hence supporting the updated ERP guideline published by BAUS.
Can We Survive? A Case of Culture Change and Learning
Authors: Daniels Genice , Tenkasi Ramkrishnan V.
Published: May 2017

In an effort towards business survival, an executive team considers progressive options for the future of their organization. The external business environment continues to change with fierce competition, a battle for talent, budget pressures and changing customer demands. What does it take for a large multinational Fortune 500 ‘logistics’ organization based in the USA to modify the culture and become an acclaimed learning organization? A decision to conduct employee ‘culture’ surveys in combination with other efforts was implemented. The authors share the experience of an organization’s odyssey to a learning organization through a change of culture.
Aquaguard-on-the-Go: Purified Water Anywhere Anytime
Authors: Vandana  , Kumar Vinod , Lenka Usha
Published: May 2017

Shapoorji Pallonji Group’s Eureka Forbes has reached 15 million customers in 550 cities of India and 35 countries globally (Sharma, 2014). Harvard Business Review has cited Eureka Forbes among six most successful sales and marketing companies in the world (Legal Era, 2012). This home appliances company has expanded its footprint by introducing a mobile water purifier Aquaguard-on-the-Go under the brand Aquaguard. Marzin R. Shroff, Eureka Forbes CEO, has claimed that Aquaguard-on-the-Go is ‘an important milestone in the history of brand Aquaguard which will take their market leadership in India to the next level’ ( Business Line, 2014). The company is excited about this product, but the question is how the company should reach target customers of this product in Indian market.
Crystal structure of the (REE)-uranyl carbonate mineral kamotoite-(Y)
Authors: Plášil Jakub , Petříček Václav
Published: May 2017

Kamotoite-(Y) is a rare supergene product of uraninite hydration–oxidation weathering and its structure is unknown. Based on single-crystal X-ray diffraction data collected with high-redundancy using a microfocus source, kamotoite-(Y) is monoclinic, has space groupP21/n,witha= 12.3525(5),b= 12.9432(5),c= 19.4409(7) Å, β = 99.857(3)°,V= 3069.8(2) Å3andZ= 4. Crystals are pervasively twinned (two-fold rotation around [0.75 0 0.75]), giving a strongly pseudo-orthorhombic diffractionpattern. The pseudoorthorhombic pattern can be described with an orthorhombic super-cell (transformation matrix 0,1,0/1,0,1/3,0,1), approximately four times larger in volume then a true monoclinic unit cell. This unit-cell is the same as the cell given elsewhere for the structure of bijvoetite-(Y),another (REE)-containing uranyl carbonate. The successful structure solution and refinement (R= 0.044 for 6294 unique observed reflections), carried out using our choice of unit cell, as well as the superstructure refinement and comparison of the original structure data forbijvoetite-(Y) reveal that these two crystal structures are identical. The crystal structure of kamotoite-(Y) consists of electroneutral sheets of the bijvoetite-(Y) uranylanion topology and an interlayer with H2O molecules not-coordinated directly to any metal cation. Despite determinationof the kamotoite-(Y) structure and demonstration that bijvoetite-(Y) has the same structure, the identity of these two minerals cannot be proved without additional study of the holotype material.
Midostaurin approved for FLT3-mutated AML
Authors: Levis Mark
Published: May 2017

Midostaurin was recently approved by the US Food and Drug Administration for the treatment of FLT3-mutant acute myeloid leukemia (AML). This is the first drug to receive regulatory approval for AML in the United States since the year 2000. Midostaurin is a small-molecule kinase inhibitor with activity against the receptor tyrosine kinase FLT3, and its approval will hopefully mark the beginning of an era of targeted agents for the treatment of molecularly defined subtypes of AML.
Thickness imaging for high-resolution stratigraphic interpretation by linear combination and color blending of multiple-frequency panels
Authors: Zeng Hongliu
Published: May 2017

Despite routine demand from petroleum explorationists and field developers, interpreting (inverting) seismic data for reservoir thickness from acoustic impedance (AI) or lithology volume requires a high-quality, unbiased well database and the special skills of elite geophysicists. I have developed a new method, based on linear combination and color blending of multiple-frequency panels, to estimate AI and thickness without the strict implementation of complex mathematics and extensive well control. Aimed at readjusting the thin-bed tuning effect in a formation of normal thickness range (up to [Formula: see text]; [Formula: see text] = dominant wavelength), a linear combination of three frequency panels from [Formula: see text] data would lead to a reasonable visual match between a sandstone (shale) body and its seismic event, should the combined amplitude spectrum roughly match the AI spectrum. A red-green-blue blending of frequency panels further extends the interpretive benefits by illustrating the thickness in color, adding a sense of thickness cyclicity on the vertical view and that of sandstone thickness map on stratal-slice view. Tests using a simple wedge model and a complex, geologically realistic multi-thin-bed model demonstrate that the proposed workflow may achieve decent geometry (thickness) estimation and reasonably high correlation ([Formula: see text]) for AI prediction with minimal or no well control. The results are similar to colored inversion in the fast-track principle, with improved stability and less error (at least in this study). More complex procedures — such as linear regression and model-based inversion — may lead to minor to moderate improvement with adequate well control. An application to a field data set confirmed the value of the methods in high-resolution reservoir-thickness imaging, with a strong potential for stratigraphically oriented studies, such as seismic chronostratigraphy, sequence stratigraphy, and seismic sedimentology.
Mortality in Children Receiving Growth Hormone Treatment of Growth Disorders: Data From the Genetics and Neuroendocrinology of Short Stature International Study
Authors: Quigley Charmian A , Child Christopher J , Zimmermann Alan G , Rosenfeld Ron G , Robison Leslie L , Blum Werner F
Published: May 2017

Context

Although pediatric growth hormone (GH) treatment is generally considered safe for approved indications, concerns have been raised regarding potential for increased risk of mortality in adults treated with GH during childhood.

Objective

To assess mortality in children receiving GH.

Design

Prospective, multinational, observational study.

Setting

Eight hundred twenty-seven study sites in 30 countries.

Patients

Children with growth disorders.

Interventions

GH treatment during childhood.

Main Outcome Measure

Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) using age- and sex-specific rates from the general population.

Results

Among 9504 GH-treated patients followed for ≥4 years (67,163 person-years of follow-up), 42 deaths were reported (SMR, 0.77; 95% CI, 0.56 to 1.05). SMR was significantly elevated in patients with history of malignant neoplasia (6.97; 95% CI, 3.81 to 11.69) and borderline elevated for those with other serious non–GH-deficient conditions (2.47; 95% CI, 0.99-5.09). SMRs were not elevated for children with history of benign neoplasia (1.44; 95% CI, 0.17 to 5.20), idiopathic GHD (0.11; 95% CI, 0.02 to 0.33), idiopathic short stature (0.20; 95% CI, 0.01 to 1.10), short stature associated with small for gestational age (SGA) birth (0.66; 95% CI, 0.08 to 2.37), Turner syndrome (0.51; 95% CI, 0.06 to 1.83), or short stature homeobox-containing (SHOX) gene deficiency (0.83; 95% CI, 0.02 to 4.65).

Conclusions

No significant increases in mortality were observed for GH-treated children with idiopathic GHD, idiopathic short stature, born SGA, Turner syndrome, SHOX deficiency, or history of benign neoplasia. Mortality was elevated for children with prior malignancy and those with underlying serious non–GH-deficient medical conditions.
Modern Puerto Rico
Authors: del Moral Solsiree
Published: May 2017

In “Modern Puerto Rico,” historian Solsiree del Moral recommends five foundational readings on the nineteenth- and twentieth-century history of Puerto Rico. The selected readings introduce nonspecialists to the history of class, race, and gender relations on the island, with a special focus on colonialism and workers. In addition, the readings explore the twentieth-century history of migration, diaspora, and national identities. Del Moral also recommends two textbooks as a resource for new readers to Puerto Rican history. The five foundational readings Del Moral recommends include: Findlay, Imposing Decency; Rodríguez-Silva, Silencing Race; Mintz, Worker in the Cane; Flores, Divided Borders; and Duany, Puerto Rican Nation on the Move.
Repeating Islands of Debt
Authors: Fusté José I.
Published: May 2017

This article performs a relational historical reading of the colonial formations that have bound Puerto Ricans to other colonial subjects throughout the US empire. It begins with an overview of the connections between how the Supreme Court contrived a state of constitutional exception that sanctioned the conquest of Native American tribes and lands and how between 1901 and 1921 they derived a similar status for the United States' insular colonies. It then foregrounds another interrelationship between Puerto Rico and its homologues: connected geostrategic and economic logics from the early to mid-twentieth century that allowed US government and private interests to reap benefits and profits from the overseas territories while impeding their economic sustainability. Finally, this article illustrates how today an updated version of US colonialism through capital investment and debt is substituting the more direct modes of control that the US empire previously employed in its far-flung colonial archipelagos.
Dynamic changes in the skeletal muscle proteome during denervation-induced atrophy
Authors: Lang Franziska , Aravamudhan Sriram , Nolte Hendrik , Tuerk Clara , Hölper Soraya , Müller Stefan , Günther Stefan , Blaauw Bert , Braun Thomas , Krüger Marcus
Published: May 2017

Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid muscle mass loss. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spectrometry to accurately quantify protein expression changes during denervation-induced atrophy after sciatic nerve section in the mouse gastrocnemius muscle (GAST). Additionally, mice were fed a SILAC diet containing 13C6 lysine for four, seven, or eleven days to calculate relative levels of protein synthesis in denervated and control muscles. Ubiquitin remnant peptides (K-ε-GG) were profiled by immunoaffinity enrichment to identify potential substrates of the ubiquitin proteasomal pathway. Of the 4279 skeletal muscle proteins quantified, 850 were significantly differentially expressed within two weeks after denervation compared to control muscles. Moreover, pulse-labelling identified Lys6 incorporation in 4786 proteins of which 43 had differential Lys6 incorporation between control and denervated muscle. Enrichment of diglycine remnants identified 2100 endogenous ubiquitination sites and revealed a metabolic and myofibrillar protein diglycine signature, including myosin heavy chains (MyHC), myomesins and titin, during denervation. Comparative analysis of these proteomic datasets with known atrogenes using a random forest approach identified 92 proteins subject to atrogene-like regulation that have not previously been directly associated with denervation-induced atrophy. Comparison of protein synthesis and proteomic data indicated upregulation of specific proteins in response to denervation is mainly achieved by protein stabilization. This study provides the first integrated analysis of protein expression, synthesis and ubiquitin signatures during muscular atrophy in a living animal.
Signal motif-dependent ER export of the Qc-SNARE BET12 interacts with MEMB12 and affects PR1 trafficking in Arabidopsis
Authors: Chung Kin Pan , Zeng Yonglun , Li Yimin , Ji Changyang , Xia Yiji , Jiang Liwen
Published: May 2017

Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs) are well-known for their role in controlling membrane fusion, the final, but crucial step, in vesicular transport in eukaryotes. SNARE proteins contribute to various biological processes including pathogen defense and channel activity regulation, as well as plant growth and development. Precise targeting of SNARE proteins to destined compartments is a prerequisite for their proper functioning. However, the underlying mechanism(s) for SNARE targeting in plants remains obscure. Here, we investigate the targeting mechanism of the Arabidopsis thaliana Qc-SNARE BET12, which is involved in protein trafficking in the early secretory pathway. Two distinct signal motifs that are required for efficient BET12 ER export were identified. Pulldown assays and in vivo imaging implicated that both the COPI and COPII pathways were required for BET12 targeting. Further studies using an ER-export-defective form of BET12 revealed that the Golgi-localized Qb-SNARE MEMB12, a negative regulator of pathogenesis-related protein 1 (PR1; At2g14610) secretion, was its interacting partner. Ectopic expression of BET12 caused no inhibition in the general ER-Golgi anterograde transport but caused intracellular accumulation of PR1, suggesting that BET12 has a regulatory role in PR1 trafficking in A. thaliana.
Age-dependent effects of water striders moving on perturbed water surfaces
Authors: Ortega-Jimenez Victor Manuel , von Rabenau Lisa , Dudley Robert
Published: May 2017

Surface roughness is a ubiquitous phenomenon in both oceanic and terrestrial waters. For insects that live at the air-water interface, such as water striders, non-linear and multi-scale perturbations produce dynamic surface deformations which may impair locomotion. We studied escape jumps of adults, juveniles, and first-instar larvae of the water strider Aquarius remigis on smooth, wave-dominated, and bubble-dominated water surfaces. Effects of substrate on takeoff jumps were substantial, with significant reductions in take-off angles, peak translational speeds, attained heights, and power expenditure on more perturbed water surfaces. Age effects were similarly pronounced, with the first-instar larvae experiencing the greatest degradation in performance; age-by-treatment effects were also significant for many kinematic variables. Although commonplace in nature, perturbed water surfaces thus have significant and age-dependent effects on water strider locomotion, and on behavior more generally of surface-dwelling insects.
Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs
Authors: Zinshteyn Boris , Rojas-Duran Maria F. , Gilbert Wendy V.
Published: May 2017

Translational control of gene expression plays essential roles in cellular stress responses and organismal development by enabling rapid, selective, and localized control of protein production. Translational regulation depends on context-dependent differences in the protein output of mRNAs, but the key mRNA features that distinguish efficiently translated mRNAs are largely unknown. Here, we comprehensively determined the RNA-binding preferences of the eukaryotic initiation factor 4G (eIF4G) to assess whether this core translation initiation factor has intrinsic sequence preferences that may contribute to preferential translation of specific mRNAs. We identified a simple RNA sequence motif—oligo-uridine—that mediates high-affinity binding to eIF4G in vitro. Oligo(U) motifs occur naturally in the transcript leader (TL) of hundreds of yeast genes, and mRNAs with unstructured oligo(U) motifs were enriched in immunoprecipitations against eIF4G. Ribosome profiling following depletion of eIF4G in vivo showed preferentially reduced translation of mRNAs with long TLs, including those that contain oligo(U). Finally, TL oligo(U) elements are enriched in genes with regulatory roles and are conserved between yeast species, consistent with an important cellular function. Taken together, our results demonstrate RNA sequence preferences for a general initiation factor, which cells potentially exploit for translational control of specific mRNAs.
Collaboration Process Pattern Approach to Improving Teamwork Performance: A Data Mining-Based Methodology
Authors: Fan Shaokun , Li Xin , Zhao J. Leon
Published: May 2017

It is well documented in management literature that characteristics of collaboration processes strongly influence team performance in a business environment. However, little work has been done on how specific collaboration process patterns affect teamwork performance, leading to an open issue in collaboration management. To address this research gap, we develop a Collaboration Process Pattern (CPP) approach that analyzes teamwork performance by mining collaboration system logs from open source software development. Our research is novel in three ways. First, our research is fact-driven, as the result is based on teamwork tracking logs. Second, we develop a pattern mining approach based on sequence mining and graph mining. Third, using time-dependent Cox regression, our approach derives business insights from real-world collaboration data that are directly applicable to managerial actions. Our empirical study identifies collaboration patterns that can lead to more efficient teamwork. It also shows that the effects of collaboration patterns vary depending on the types of tasks. These findings are of significant business value since they suggest that managers should carefully prioritize their limited attention on certain types of tasks for intervention.

Data and the online supplement are available at https://doi.org/10.1287/ijoc.2016.0739 .
Recognising mathematical mastery in child-led play
Authors: Chilvers Di
Published: May 2017

Following on from April's look at how talk can be used to improve children's maths understanding, we return to the subject to explore how the process can be further enhanced by using Learning Stories.
Quality of paediatric hospice care for children with and without multiple complex chronic conditions
Authors: Lindley Lisa C , Keim-Malpass Jessica
Published: May 2017

Background:

Hospice care for children with multiple complex chronic conditions (MCCC) is complicated given their unique health at the end of life (EOL). Little is known about the quality of the hospice care MCCC children receive and how that might differ from children without MCCC.

Objective:

To compare the quality of hospice care (i.e., structures, processes, outcomes) between children with and without MCCC.

Methods:

This retrospective, comparative study used data from the National Home and Hospice Care Survey, which included a nationally representative sample of paediatric hospice patients. The Pearson chi-square and Wald tests for comparisons were used.

Results:

MCCC children enrolled in hospice care for over 2 months with multiple visits by hospice staff. They had low symptom burden with minimal discontinuity of care at EOL. Children without MCCC had short length of stays in hospice with few visits by nurses and other clinicians. These children had high symptom burden and significant disenrollment from hospice care to receive more aggressive treatment.

Conclusions:

The findings revealed significant differences in paediatric hospice care between MCCC and non-MCCC children, which provides critical insight into the quality of hospice care.
Pengaruh Konsolidasi Lahan Perkotaan terhadap Harga Tanah di Ringintelu, Kelurahan Kalipancur - Kota Semarang
Authors: Mulyanti Wuri
Published: May 2017

Perubahan kota Semarang salah satunya ditandai melalui proses pengkotaan seperti peningkatan kebutuhan lahan yang disebabkan meluasnya pemukiman, fasilitas ekonomi, perdagangan dan jasa serta jaringan infrastruktur. Hal ini menyebabkan terjadinya perubahan fisik lingkungan dan perebutan lahan sehingga harga tanah menjadi tidak terkendali. Salah satu upaya pemerintah untuk mengurai permasalahan ini adalah penataan lingkungan melalui program konsolidas i lahan perkotaan. Program ini diharapkan mampu meningkatkan harga tanah yang ada, sehingga tidak akan muncul adanya lahan tidur/”idle land” seperti di lokasi peneltian. Hal inilah yang melatarbelakangi pentingnya penelitian mengenai pengaruh konsolidasi lahan perkotaan di Ringintelu, Kelurahan Kalipancur - Kota Semarang. Tujuannya adalah mengkaji pengaruh konsolidasi lahan perkotaan terhadap harga tanah di Ringintelu, Kelurahan Kalipancur - Kota Semarang. Metode penelitian ini menggunakan pendekatan kuanti tatif dengan analisis faktor, crosstab dan regresi berganda untuk mengetahui tingkat hubungan dan pengaruhnya. Hasil yang diperoleh dalam penelitian ini adalah adanya hubungan antara konsolidasi lahan dengan harga tanah di Ringintelu Kelurahan Kalipancur Kota Semarang. Hubungan ini berpengaruh sebesar 81,1 terhadap kenaikan harga tanah sebesar 400% hingga 900% yang secara tidak langsung dipengaruhi oleh adanya program konsolidasi.  Pengaruh dikatakan tidak langsung karena faktor-faktor seperti aksesibilitas dan pengembangan sarana dan prasarana terjadi sebagai akibat adanya program konsolidasi lahan selain juga karena pengaruh faktor lainnya.Kata kunci : konsolidasi lahan, harga tanah, harga pasar
Penentuan Lokasi Industri Olahan Karet UIKM di Kabupaten Sijunjung
Authors: Christina Shelly , Pigawati Bitta
Published: May 2017

Perkebunan karet merupakan salah satu komoditi unggulan dan sumber mata pencaharian utama masyarakat di Kabupaten Sijunjung. Hasil produksi karet yang dikelola oleh masyarakat pada saat ini masih dalam bentuk slab/ojol  ( bekuan karet )  tanpa pengolahan lebih lanjut dikarenakan belum tersedianya industri pengolahan karet di Kabupaten Sijunjung, sehingga mengakibatkan rantai pemasaran menjadi cukup panjang dan harga yang diterima petani berkisar 50-55% dari harga pabrik. Tujuan dari penelitian ini adalah penentuan lokasi industri olahan karet UIKM di Kabupaten Sijunjung. Metode penelitian yang digunakan adalah kuantitatif deskriptif dengan teknik pembobotan  ( scoring) dan weighted overlay. Analisis dilakukan dengan mempertimbangkan variabel kesesuaian lahan industri olahan karet UIKM, aksesibilitas, sarana pendukung, nilai lahan, biaya transportasi dan kebijakan RTRW Kabupaten Sijunjung. Hasil penelitian menunjukkan bahwa terdapat 7 Kecamatan dan 31 Nagari yang sesuai menjadi lokasi industri olahan karet UIKM. Namun dari 7 Kecamatan tersebut, daerah yang paling direkomendasikan adalah Kecamatan Kamang Baru terutama Nagari Takung dan Sungai Lansek karena daerah tersebut merupakan daerah yang diizinkan oleh Pemerintah Daerah untuk pembangunan agroindustri dan menjadi penghasil karet terbanyak di Kabupaten Sijunjung serta dialiri oleh jaringan jalan arteri primer, listrik dan memiliki sumber air bersih.Kata kunci : lokasi industri, karet, UIKM, kesesuaian lahan, aksesibilitas, sarana pendukung, nilai lahan, biaya transportasi
Comparative Design, In Silico Dockingand Predictive ADME/ TOX Properties of Some Novel 2, 4-hydroxy Derivatives of Thiazolidine-2, 4-diones as PPARÎ³ Modulator
Authors: Yasmin Sabina , Mhlongo Ndumiso N. , Soliman Mahmoud E. , GR Saraswathy , Jayaprakash Venkatesan
Published: May 2017

Peroxisome proliferated receptors (PPARs) are important targets for drugs used in the treatment of various metabolic disorders. We have reported 4-hydroxy benzylidene derivatives of thiazolidine-2,4-diones with reversed orientation in the active site of PPARÎ³in our earlier communication. With the reversed conformation of TZD, fitting the established pharmacophore was discussed. The current simulation studies revolves around the 2,4-dihydroxy benzylidene derivatives expecting H-bonding interactions similar to Rosiglitazoneâ€™s acidic head. The docking protocol was validated by enrichment studies using decoys and actives from DUD. Designed compounds were showing interactions similar to the actives in the top 10%, 5% and 1%. They also exhibited H-bonding interactions similar to their monohydroxy counterparts without any additional H-bonding interactions due to introduction of additional hydroxy functional groups. Predicted ADMET report reveals that 5 molecules show favourable hERG-I and -II properties and nine compounds show best metabolic stability.
A Note on the Application of Dynamic Panel Data (DPD) Models in Economic Models of Crime
Authors: Ghasemi Mojtaba
Published: May 2017

The dynamic panel data (DPD) model and application of Difference and System GMM estimators has great advantages to address endogeneity of law enforcement variables and measurement error in reporting of crimes in economic models of crime as well as controlling for fixed effects and avoiding dynamic panel bias. Meanwhile, neglecting instrument proliferation which is very common and uncommonly detected in these models can lead to misleading and unreliable results. Bolding this warning and presenting available techniques to control for this potential danger is the main mission of this note.
Banks Restructuring Sonata: How Capital Injection Triggered Labor Force Rejuvenation in Japanese Banks
Authors: Osada Takeshi , Onji Kazuki , Vera David
Published: May 2017

Divergent interests of bank managers and financial regulators potentially compromise the efficacy of bank rescue operations. This study empirically investigates the agency problem encountered in a capital injection program implemented in Japan. We hypothesize that the operations requirement to reduce workforce lead banks to overstate the extent of downsizing by reassigning older workers to bank subsidiaries. We implement a difference-in-differences analysis using a panel of Japanese banks from 1990 to 2010. We also employ propensity score matching to control for sample selection bias. The result shows that injected banks exhibit workforce rejuvenation relative to non-injected banks. Among injected banks, the average employee age falls by approximately 1 year, which is equivalent to a reduction of approximately seventy 65-year-old workers. On an unconsolidated basis, the number of employees in injected banks decreases as a response to the injection. However, on a consolidated basis, which accounts for subsidiary employment, the number of employees does not decrease. Our finding suggests that the Japanese practice of lifetime employment (LTE) survived, albeit in a limited form, among restructured banks.
Physiological and biochemical aspects of flower development and senescence in Nicotiana plumbaginifolia Viv.
Authors: Nisar Shaziya , Tahir Inayatullah , Ahmad Syed Sabhi , Dar Riyaz Ahmad
Published: May 2017

Healthy buds of Nicotiana plumbaginifolia growing in the Kashmir University Botanic Garden were selected for the present study. Flower development and senescence was divided into seven stages, viz., tight bud stage (I), mature bud stage (II), pencil stage (III), partially open stage (IV), open stage (V), partially senescent stage (VI) and senescent stage (VII). Various physiological and biochemical changes were recorded at each stage of flower development and senescence. Floral diameter, fresh mass, dry mass and water content showed an increase up to flower opening (stage V) and thereafter a significant decrease was recorded as the flower development progressed towards senescence through stages VI and VII. An increase in α-amino acids, total phenols and sugars was registered towards anthesis (stage V) and a decrease in these parameters was recorded with senescence. Protease activity showed a significant increase towards senescence with a concomitant decrease in soluble proteins. Based on the quantitative analysis of various biochemical parameters, the flower opening in N. plumbaginifolia seems to be accompanied by an increase in the water content, soluble proteins, α‑amino acids and phenols. A decrease in these parameters, besides an increase in protease activity induces senescence in the beautiful flowers of N. plumbaginifolia. Understanding flower senescence may help in improving the postharvest performance of this beautiful ornamental flower to make it a potential material for the floriculture industry.