bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Dilaton Dynamics: Gravitational Lensing and Cosmological Implications
Authors: Stephenson Matthew James
Published: February 2024

This study delves into the intricate interplay between cosmology and gravity in dilaton-based models, enhancing our understanding. Exploring boundary theories coupled to gravity, we derive a four-dimensional effective theory from the cosmological constant. Dilaton gravity is then scrutinized, revealing elegant solutions and insights into brane embedding. The analysis extends to probe scalar fields, employing the WKB approximation in both conformal and non-conformal cases. In summary, this work contributes to a nuanced understanding of the complex relationship between cosmology and gravity in dilaton-based frameworks.
Reflects on Knowledge Production in Humanities from an Academic Exchange Experience
Authors: Napoli Mariangela
Published: February 2024

Over the last two decades, knowledge production, research and reconfiguration of universities have been understood as ways of giving new meanings to the university-society binomial. In this regard, humanities are the subject of multiple debates in the face of ideas about their impact in relation to the "other sciences". Based on these premises, this article sets out to explore possible meanings attributed by researchers to the concepts of commitment, mobilization and transfer of research in humanities in view of the debates on the university-society interaction and the third mission of the university (Alonso, Cuschnir and Napoli, 2021). The methodology used will address bibliographical analysis, theoretical background and statements from different institutions, as well as the analysis of material from four interviews. As a first instance, the preliminary results show that strengthening critical thinking as forms of commitment emerge as central senses, focusing on hungarian characteristics and productions in order to unravel the ways of understanding and imagining Eastern European reality. In this respect, the discussion of certain western knowledge is seen as a task associated with social commitment with public universities as a focus of resistance.
Magnetorheological Polishing Based on Honing Vertical Mechanism for Inner Surface of Titanium Alloy Pipes
Authors: Song Wanli , Yang Zhen , Meng Dezhi , Wang Na , Choi Seung-Bok
Published: February 2024

Recently, a high internal surface of the titanium alloy pipe is required due to the increment of various applications of the pipe such as aerospace. However, the traditional machining process is unable to effectively polish the internal surface of the slender pipe. Thus, a vertical magnetorheological polishing (VMRP) apparatus is carried out in this work to implement high polishing performance on the internal surface of the titanium alloy pipe. The polishing process is realized by the combination of the rotating motion of the pipe and the reciprocating linear motion of the polishing head. Moreover, a series of comparative experiments are conducted to investigate the polishing mechanism of magnetorheological (MR) fluid and enhance the polishing performance. It is shown from the experimental results that proposed VMRP approach exhibits the better polishing performance than the conventional horizontal MR polishing method under same testing conditions. This is because the proposed VMRP method well eliminates the traces of polishing particles owing to the combination of polishing particles with different sizes. In addition, it is identified from the experimental test that the polishing time of the VMRP required to achieve the same polishing effect as the conventional method is shortened under the combination of different rotation speeds. It is identified from the above benefits of the VMRP that the final surface roughness after polishing is below 0.05 μm.
Reimagining Urban Heritage: Counter-Mapping as a Disruptive Tool in the Transformation of Sustainable and Touristic Cities
Authors: Soler Seila , Rosser Limiñana Pablo
Published: February 2024

This study assessed the impact of counter-mapping on university students' perception and knowledge of their cities, focusing on cultural diversity, urban dynamics, and social challenges. Using a quasi-experimental design with pretests and posttests in the province of Alicante, Spain, changes in the understanding of urban geography, everyday life, and cultural diversity were analyzed among 54 Geography Didactics students. Likert scale surveys and open-ended questions were employed, complemented by statistical and qualitative analyses, to measure knowledge and perceptions before and after the counter-mapping project. The results indicate that although quantitative correlations did not show statistically significant significance, qualitative analysis revealed significant and profound learning. Participants uncovered the hidden layers of their urban environments and gained a better understanding of the complexities and challenges of their cities. The project promoted the development of critical skills such as analytical thinking, active research, and effective communication, proving to be a valuable pedagogical tool that surpasses the limitations of traditional teaching methods and encourages active and committed citizenship. This inclusive and multidimensional approach enriches the diversity of experiences and knowledge, significantly contributing to the teaching of urban subjects, community engagement, and social responsibility, laying the groundwork for proper tourist, cultural, social, or urban planning of city spaces.
Treatments for Cannabis Use Disorder Across the Lifespan: A Systematic Review
Authors: Ghafouri Mohammad , Correa da Costa Sabrina , Zaredehnavi Ali , Gold Mark S , Rummans Teresa A
Published: February 2024

Cannabis use disorder (CUD) is a growing public health concern, with rising prevalence and significant impact on individuals across age groups. This systematic review examined pharmacological and psychosocial interventions for CUD among adolescents, young adults, transitioning adults, and older adults. Database searches were conducted for randomized controlled trials of CUD interventions reporting outcomes such as cannabis use, abstinence, withdrawal symptoms, and treatment retention. In total, 53 studies were included. Pharmacological treatments such as cannabinoid agonists, gabapentin, and N-acetylcysteine demonstrated modest benefits predominantly in alleviating withdrawal and craving. Psychosocial approaches including motivational interviewing, cognitive behavioral therapy, and contingency management conferred greater abstinence and retention, either alone or combined with pharmacotherapy. However, age-specific efficacy remains unclear. Technology-based interventions represent promising alternatives to expand access and improve cost-effectiveness. In conclusion, cannabis disorders require expanded, affordable treatment tailored to individuals’ developmental stage. Further research should clarify the utility of harm reduction outcomes and establish age-specific best practices.
Research on a SLAM Method Based on Semantic Information
Authors: SUN Ruo-huai , ZHAO Xue , DU Zhen-jun , WU Cheng-dong , ZHAO Bin
Published: February 2024

This paper proposes a solution for the problem of mobile robot navigation and trajectory interpolation in dynamic environments with large scenes. The solution combines a semantic laser SLAM system that utilizes deep learning and a trajectory interpolation algorithm. The paper first introduces some open-source laser SLAM algorithms and then elaborates in detail on the general framework of the SLAM system used in this paper. Secondly, the concept of voxel is introduced into the occupation probability map to enhance the ability of local voxel maps to represent dynamic objects. Then, in this paper, we propose a PointNet++ point cloud semantic segmentation network combined with deep learning algorithms to extract deep features of dynamic point clouds in large scenes and output semantic information of points on static objects. A descriptor of the global environment is generated based on its semantic information. Closed-loop completion of global map optimization is performed to reduce cumulative error. Finally, T-trajectory interpolation is utilized to ensure the motion performance of the robot and improve the smooth stability of the robot trajectory. The experimental results indicate that the combination of the semantic laser SLAM system with deep learning and the trajectory interpolation algorithm proposed in this paper yields better graph building and loop closure effects in large scenes at SIASUN large scene campus. The use of T-trajectory interpolation ensures vibration-free and stable transitions between target points.
A Successful Approach in Diagnosing Shiga - Toxin Producing Escherichia coli -Induced Colitis
Authors: Melinte Violeta , Văcăroiu Cristina Maria , Radu Adelina Maria , Cismaru Miriana Ioana , Călinoiu Amalia Loredana , Rusu Adina , Oprescu Macovei Anca Monica , Ciocîrlan Mihai , Tianu Elena Cristina , Mîrzan Luminița , Mihăilă Daniela Elena , Trandafir Ioana Veronica , Bugeac Mitacu Claudia Sorina , Gheorghiță Valeriu
Published: February 2024

Shiga-like toxin producing Escherichia coli (STEC) is a well-known cause of foodborne acute diarrheic diseases especially in children and the elderly. The potentially fatal complications associated with toxin production range from bloody diarrhoea and ischemic colitis to kidney failure, haemolytic-uremic syndrome (HUS) and colon perforation.
We describe a case and literature review of STEC – induced colitis, highlighting the clinical features, and the necessary tools for the best diagnosis approach and management. Facing challenging differential diagnosis ranging from ischemic colitis, inflammatory bowel disease, to infectious process due to a pathogenic or opportunistic agent, we practiced a step-by-step exploration. Beginning with bacteriological investigation, imagistic screening, and colonoscopy, we could rule out some of initial suppositions and reach the final diagnosis, also considering the pathological results. Although antibiotics are not indicated in this pathology, our patient did receive antibiotics, given the risk of translocation and colon perforation, without associating any complications, as HUS or peritonitis.
Detailed and rigorous investigations along with a multi-speciality team are required for a prompt medical support. Coping the symptoms and refraining from further complications are the mainstem of the treatment.
Method and Simulation of a Power Supply System Operation Based on Methane Generator Supported by Energy Storage System, to Cover High Fluctuation Electrical Loads: Greenhouse Case Study
Authors: Elmasides Costas
Published: February 2024

The analysis presented is based on actual GHU energy demand. The special feature of this load is the existence of strong daily fluctuations in energy consumption, especially during the summer months. This study presents a methodology for managing such loads with the main objective of maximizing the operating efficiency of MG.
Reactivation of Varicella‐Zoster Virus in Patients with Lung Cancer Receiving Immune Checkpoint Inhibitors: Retrospective Nationwide Population‐ Based Cohort Study of the Health Insurance Review and Assessment Database in South Korea
Authors: Jung Jiyun , Park Seong Yeon , Park Jae Yoon , Kim Dalyong , Lee Kyoungmin , Choi Sungim
Published: February 2024

Background
This study aimed to determine the association between immune checkpoint inhibitors (ICIs) and the risk of herpes zoster (HZ) incidence in patients with lung cancer.

Method
We obtained national claims data of 51,021 patients from South Korea with lung cancer between August 2017 and December 2021. The study population was classified into ICIs and non-ICIs groups based on prescription of ICIs at least once during the study period. To estimate the effects of ICIs treatment compared with those without ICIs treatment on HZ incidence, we used the Cox proportional hazards model adjusted for sex, age, comorbidities, and concomitant use of immunosuppressive drugs. Stratified analyses based on sex, age, and comorbidities were conducted to identify corresponding risk factors.

Results
Of the 51,021 study participants, 897 (1.8%) were prescribed ICIs, and 2,262 (4.4%) were diagnosed with HZ. Approximately 75.6% of the patients were male, and the prevalence of diabetes, cardiovascular disease, and chronic lung disease in the ICIs group was significantly lower than that in the non-ICIs group. The Kaplan–Meier plot showed that the probability of incidence of HZ in the ICIs group was lower than that in the non-ICIs group. Additionally, treatment with ICIs was associated with a 31% lower risk of developing HZ when compared to that seen without ICIs treatment (95% confidence interval [CI], 0.48–1.00). This association was stronger in females (hazard ratio [HR], 0.42; 95% CI, 0.19–0.94) and those less than 68 years of age (HR, 0.58; 95% CI, 0.34–0.99).

Conclusion
In these real-world data from an Asian population with lung cancer, ICIs treatment might be associated with a reduced risk of HZ compared to that without ICIs treatment.
Concurrent High Risk HPV35, HPV45, and HPV59 Infections in Prostate and Bladder Cancer Tissues of a Single Patient
Authors: Ahmed Mohammed Yahya , Salman Nadia Aziz , Cakir Muharrem Okan , Sandhu Sarbjinder , Ashrafi G Hossein
Published: February 2024

Human papillomavirus (HPV) infections, primarily transmitted through sexual contact, have been linked to various cancers, including cervical, penile, anal, oropharynx, breast, and prostate cancers. This study presents a unique case of concurrent high-risk HPV35, HPV45, and HPV59 infections in both prostate and bladder cancer tissues from a single patient, representing the first documented instance worldwide with identical HPV types detected in two adjacent organs of the same individual. Employing a multiplex-PCR approach, gel electrophoresis, and Sanger sequencing, we confirmed the presence of these high-risk HPV types. Additionally, Western blot analysis using an HPV E7 antibody demonstrated the active expression of HPV oncoproteins in both cancer types. This discovery underscores the potential for HPV intra-organ transmission and necessitates further exploration of alternative transmission routes. The implications of our results offer new insights into the complex dynamics of HPV transmission in cancer pathogenesis.
Securing Large Healthcare Files in Cloud-Blockchain Integration: A Comprehensive Review
Authors: Ramirez Lopez Leonardo Juan , Millan David Felipe , Martinez Luis Hernando , Carbonell Andres , Rojas Reales Wilson Mauro
Published: February 2024

The management of large medical files is a critical challenge in the health sector. Conventional systems have security, scalability, and efficiency deficiencies. This project proposes a hybrid architecture between blockchain and cloud computing to address these challenges. Blockchain ensures the immutability and traceability of medical records, while the cloud allows scalable and efficient storage. Together, these technologies can transform data management in electronic health record applications. The essential objective of this research is to thoroughly look at the existing strategies, devices, and conventions that encourage a secure interaction between blockchain applications and the cloud. Special emphasis is set on maintaining the integrity and security of the blockchain while tackling the potential and efficiency of cloud infrastructures. Through a meticulous investigation of these approaches, along with their successful usage and encountered challenges, this paper offers a comprehensive overview of the present state of this integration. Altogether, this paper does not propose new concepts or developments. Its central focus is to provide a comprehensive and insightful examination of the modern landscape concerning the integration of blockchain and cloud advances. By shedding light on the existing approaches and assessing their viability, this work aims to highlight the current challenges and build up a solid establishment for future development. This, in turn, will cultivate a consistent integration of blockchain security with the dynamic potential of cloud computing while guaranteeing information integrity and security remain uncompromised. In conclusion, this paper serves as a important resource for analysts, specialists, and partners looking for to dig into and development the integration of blockchain and cloud innovations, subsequently contributing to a more secure and productive cloud environment.
The Potential Use of Soluble TREM Like Transcript – 1, a Platelet-Specific Receptor, for Early Detection of Anthracyclines Induced Congestive Heart Failure (CHF) in Leukemia Patients
Authors: Branfield Siobhan , LaGrand Susan , Cleary Ian , Gibson Angelia , Washington Anthony Valance
Published: February 2024

Leukemia, contributing to 3% of all cancer cases in the United States, presents a significant challenge in treatment due to its diverse subtypes, each dis-playing unique genetic and molecular abnormalities. The aggressive growth of ab-normal blood cells compromises immune function and poses challenges in developing effective therapeutic approaches. Unlike solid tumors, surgical resection is not an option, limiting treatment strategies to chemotherapy, immunotherapy, and radiation therapy, which may be nonspecific and lead to organ damage and toxicity.

Anthracyclines, widely used in hematological tumors, face limitations due to severe cardiotoxicity, causing progressive cardiomyopathy and, in severe cases, congestive heart failure. Heart failure incidence is significantly higher in cancer patients treated with anthracyclines over 5, 10, and 15 years. Early detection of left ventricular dysfunction and cardiotoxicity is crucial to mitigate progression to congestive heart failure (CHF) in this population.

Recent research by Bayrón-Marrero et al. reveals that lower levels of plasma soluble TREM-Like Transcript-1 (s-TLT-1), a platelet-specific receptor, correlate with left ven-tricular dysfunction in cardiovascular disease patients. Those with s-TLT-1 levels ex-ceeding 544 pg/mL exhibit a significant association with congestive heart failure. These findings suggest the potential use of s-TLT-1 as a diagnostic screening tool for early detection and treatment of anthracycline-induced CHF in leukemia patients.
The Effect of Tai Chi Exercise on Anxiety Disorders of The Elderly
Authors: Rahayu Mifta Amalia Rizka
Published: February 2024

Ageing or old age is the final stage in the evolution of the human life cycle that every individual will surely experience. Some diseases start to emerge and are expected at this age; one of them is anxiety disorder. If an older adult has an anxiety disorder, it will affect memory and sleep patterns. This study aimed to find out the impact of Tai Chi gymnastics on anxiety disorders in the elderly in the city of Surakarta. The method used is a qualitative method using relevant journals and reverence. Given the large number of cases of ageing anxiety disorder, there is a need for treatment. Usually, elderly enthusiasts do simple, easy activities like gymnastics in an attempt to heal themselves. Tai Chi exercises are ideally suited to be applied to the elderly because the influence of Tai Chi has proven to be effective in reducing anxiety disorder. Tai Chi exercises usually use circular movements, which are never forced so that the muscles do not feel tense but relax. The results of this study can conclude that Tai Chi exercises are straightforward and suitable for older people as an attempt to treat anxiety disorder.
Confucius: A Philosophy of Life in Chinese Society
Authors: Rasyid Hemas Mutia , Lestari Fitri Khairunisa
Published: February 2024

The country of China is the birthplace of the leading philosophers, one of whom is Kong Zi, better known as Confucius. By his wisdom, he was entrusted as Minister of Public Works, Commissioner of Police, and Minister of Justice by the king during the Zhou Dynasty when he was 35 to 60. This research aims to explain Kong Zi's philosophy of life as profoundly as possible using data collection that has been studied. The analysis is written using a qualitative method of data collection. After Kong Zi did not serve in government, he wrote a lot and published books about poetry and poetry. This great philosopher also often takes time to share knowledge with his disciples. Kong Zi teaches his pupils first to understand life and relations with fellow human beings. The Confucian view of life emphasizes life in the world by not involving mystical things, and advancing critical thinking makes Confucius look more modern. The popularity of the philosophy of life by the Confucian to this day is still widely used by many people.
Health Risks of Unaccompanied Immigrant Children in Federal Custody and in US Communities
Authors: Young Janine , Binford Warren , Bochenek Michael Garcia , Greenbaum Jordan
Published: February 2024

Unaccompanied immigrant children continue to arrive at the US–Mexico border and are at high risk for ongoing abuse, neglect, and poor mental and physical health.

We are medical and legal experts in the fields of immigrant and refugee health, child abuse, and the legal rights of international refugee and migrant children. We provide an overview of US federal agencies with custody of unaccompanied immigrant children, a summary of medical care provided while in custody, and recent findings from the independent Juvenile Care Monitor Report mandating new custodial conditions for immigrant children while in federal custody.

We provide recommendations to improve the health and well-being of unaccompanied immigrant children while in custody and once released to US sponsors. ( Am J Public Health. 2024;114(3):340–346. https://doi.org/10.2105/AJPH.2023.307570 )
Plan de negocios para comercialización y distribución de hamburguesas de sangrecita y garbanzos
Authors:   , Chuño Vizarreta Sinddy Nataly , Figueroa Rimache Manuel Alexander , Gonzalez Csirke Isabel Lourdes , Tanta Valdez Anali del Pilar , Torres Mestanza Barbara Miluska
Published: February 2024

Ayudar es la base del concepto del negocio teniendo como base a los consumidores a generar el buen hábito de alimentación y reducir el consumo de comidas pocas nutritivas que son perjudiciales para la salud y es por ello que ofrecemos nuestras ricas hamburguesas de garbanzos con sangrecita de pollo la cual está dirigido para el público en general y sobre todo para minorar el porcentaje de la anemia, desnutrición en nuestro país.
La aplicación de la tecnología IIoT con respecto a la eficiencia operativa dentro de la planta de tratamiento y envasado de agua caso Consorcio FRAP – GLACIAL, Lima 2019
Authors:   , Chiri Navarro Daniel Mauricio
Published: February 2024

La siguiente investigación tuvo como finalidad dar a conocer los estudios realizados en la elaboración de una metodología de prevención utilizando la tecnología IIoT dentro de la planta de tratamiento y envasado de agua en la empresa Consorcio Frap S.A.C., obteniendo resultados que aumentaron considerablemente la eficiencia operativa. Se parte de la entrega de descripción del problema y de los objetivos generales y específicos de la investigación. Una vez descrito el problema, se evaluó el periodo Enero – Diciembre 2019 con los formatos de llenado de producción para identificar las causas raíz de las restricciones que habían reducido la eficiencia operativa, para ello se utilizó el Diagrama de Pareto, reconociendo a las máquinas soplador y envasadora como generadoras de mayor número de deficiencia, es en ese momento que la eficiencia operativa es llamada Eficiencia Global de las Máquinas OEE. Esta investigación tiene un enfoque cuantitativo, es de tipo diseño de preprueba – postprueba y tiene un diseño preexperimental. Para obtener información, se utilizaron los indicadores OEE de pre-aplicación (enero-diciembre 2019) y post aplicación (enero 2022) se determinó los resultados con el software de análisis estadístico Minitab Statistical Software, así como también el software estadístico R con prueba de Normalidad y Prueba U de Mann-Whitney. Esta investigación cumplió con demostrar que la tecnología IIoT logro aumentar significativamente la Eficiencia Global de los Equipos, la cual esta alineada con sus dimensiones rendimiento, disponibilidad e índice de calidad.
Calidad de servicio y su impacto en la satisfacción del cliente en un mercado cooperativo, distrito de Chorrillos (Lima-Perú), 2022
Authors:   , Cecilio Llamocca Nely Lisett , Ramos Andrade Sara Esther
Published: February 2024

A lo largo de la historia, las empresas y entidades han persistido en su esfuerzo constante por valorar la excelencia de sus servicios y, a partir de las conclusiones obtenidas, realizar mejoras con la finalidad de incrementar la satisfacción de sus clientes. El enfoque principal del estudio estuvo dirigido a analizar cómo la calidad del servicio impacta en la satisfacción de los clientes en un mercado cooperativo. Para facilitar la comprensión, se subdividieron ambas variables en cinco dimensiones distintas. Desde una óptica metodológica, este estudio se basó en un enfoque cuantitativo con un enfoque de correlación causal y empleó un diseño no experimental. La muestra consistió en 132 clientes que residían en el distrito de Chorrillos y eran clientes habituales del establecimiento en estudio. Se administró un cuestionario que constaba de 30 preguntas estructuradas en formato de escala de Likert para recopilar datos de los participantes. Tras la recopilación y el análisis de los datos, se pudo constatar de manera concluyente que, existe una correspondencia relevante entre la calidad del servicio y la satisfacción del cliente (p <0,05), tal como lo indica el coeficiente de Nagelkerke obtenido, que se situó en 0,393.
Influencia de un recubrimiento comestible a base de la mezcla de goma de tara (Caesalpinia spinosa) sobre la calidad de higos (Ficus carica) refrigerados, 2021
Authors:   , Tucto Cueva Yeli Zaida
Published: February 2024

El higo fresco (Ficus carica) es un fruto climatérico con una vida útil corta. Se ha estudiado el impacto del recubrimiento comestible y sus ingredientes aplicados sobre el higo debido a las mermas que se dan después de la recolección durante el acopio con el fin de brindar innovadoras soluciones para ampliar la vida útil y conservar la calidad del higo, además de ser una alternativa de conservación sostenible. Como resultado, el objetivo de la tesis fue determinar cómo las composiciones de recubrimientos comestibles obtenidas en la mezcla de goma de tara (Caesapinia spinosa), cera de abeja y glicerol afectan a los criterios de calidad durante el almacenamiento. Para lograr este objetivo, se implementó el diseño de mezclas utilizando el programa Design Expert® 13. Se evaluó la efectividad de dieseis formulaciones experimentales del recubrimiento comestible, teniendo en cuenta las variables estudiadas de los higos en estado pintón (nivel de madurez), después de 21 días de almacenamiento a 5 °C y 45% de humedad relativa. Luego, se estimaron las proporciones de los tres componentes principales a través de las funciones matemáticas, dándonos como resultado un polinomio de segundo grado. En seguida, se utilizaron los trazos de Cox para evaluar el impacto de los componentes de la investigación en las variables de respuesta. Finalmente, se utilizó Deseabilidad Global para determinar la mejor formulación. Esto nos permitió aumentar la firmeza y la luminosidad de los higos al mismo tiempo que se reducía el peso y la tasa de respiración. Los resultados demostraron que el recubrimiento comestible con la formulación más adecuada fue el 0,3% de goma de tara, 0,25% de cera de abeja y 0,45% de glicerol. Esto permitió una pérdida de peso del 4,74 por ciento, una firmeza de 17,84 N, una tasa…
Relación entre el conocimiento de los padres acerca del etiquetado de información nutricional y el consumo de alimentos industrializados sobre el estado nutricional de niños de 6 a 12 años
Authors:   , Sosa Macalupu Marjhory Aracely
Published: February 2024

Fundamentos: El objetivo del presente estudio fue determinar la relación existente entre el conocimiento de los padres acerca del etiquetado de información nutricional, se refiere al etiquetado nutricional y al etiquetado frontal, y el consumo de alimentos industrializados en escolares con el estado nutricional de los mismos escolares de 6 a 12 años del distrito de San Juan de Lurigancho, Lima-Perú. Métodos: Estudio cuantitativo, observacional y transversal. Se utilizó un muestreo de tipo no probabilístico, por conveniencia. Donde se aplicaron dos cuestionarios para la recolección de información sobre el conocimiento del etiquetado nutricional y etiquetado frontal en 255 padres de escolares de 6 a 12 años, además se aplicó un cuestionario de frecuencia de consumo de alimentos industrializados y se hicieron mediciones antropométricas a los 255 escolares evaluados. Se utilizo el aplicativo WHO Anthro Plus para los diagnósticos nutricionales y el software JASP para completar los análisis estadísticos. El proceso de recolección de datos se realizó de manera presencial, durante los meses de setiembre a diciembre del 2022. Resultados: Del total de los padres que participaron el 65,10% tenía un nivel de conocimiento bajo del etiquetado de información nutricional y el 80% un nivel de conocimiento deficiente del etiquetado frontal. Respecto a los escolares el 64,71% presentó un bajo consumo de alimentos industrializados, un 60,78% presentaban sobrepeso u obesidad y un 39,61% tenían un alto o muy alto riesgo cardio metabólico según PAB. Además, se halló una relación significativa entre el conocimiento de los padres acerca del etiquetado de información nutricional y el PAB de los escolares (p<0,05), también se encontró una significancia estadística (p<0,01) entre el IMC y el PAB de los escolares. Conclusiones: Existe relación significativa entre el conocimiento de etiquetado nutricional de los padres y el consumo de alimentos industrializados sobre…
Turn on the Light: Why tackling energy-related challenges in the nexus of water and food in Syria cannot wait
Authors: Cervi Anna
Published: February 2024

This discussion paper contributes to the broader discourse on the nexus between Water, Energy and Food (WEF) in parts of Syria where Oxfam works. It explores the main causes behind the deterioration of the WEF sectors and the impact they have on households across Syria. The paper also focuses on aspects that directly impact and limit Oxfam's work inside Syria, in the delivery and implementation of Water, Sanitation and Hygiene; Livelihoods; Food Security and Protection interventions. Addressing the WEF Nexus in Syria is key in delivering more effective and sustainable interventions; and helping Syrians restore their lives.
ФЕДЕРАЛЬНЫЙ ПРОЕКТ «ЭКОНОМИКА ЗАМКНУТОГО ЦИКЛА»: ВОЗМОЖНОСТИ И УГРОЗЫ ДЛЯ РАЗВИТИЯ АРКТИЧЕСКОЙ ЗОНЫ РФ
Authors: Головина Т. А.
Published: February 2024

В статье раскрыта сущность экономики замкнутого цикла, а также выделены основные направления ее развития в России в рамках федерального проекта. Сделан акцент на актуальности развития технологий экономики замкнутого цикла в Арктической зоне России.
ЛЕСОПРОМЫШЛЕННЫЙ КОМПЛЕКС РОССИИ В УСЛОВИЯХ САНКЦИЙ
Authors: Гордеев Р. В.
Published: February 2024

Целью работы является оценка последствий санкционных ограничений для отечественной лесной промышленности. Результаты демонстрируют снижение показателей финансовой отчетности лесных компаний по сравнению с высокой базой 2021 г. наряду с постепенным перестраиванием торговых потоков и логистики.
The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea
Authors: Robinson Robert , Tran Linh , Akil Caner , Senju Yosuke
Published: February 2024

Membrane-enclosed organelles are defining features of eukaryotes in distinguishing these organisms from prokaryotes. Specification of distinct membranes is critical to assemble and maintain discrete compartments. Small GTPases and their regulators are the signaling molecules that drive membrane-modifying machineries to the desired location. These signaling molecules include Rab and Rag GTPases, roadblock and longin domain proteins, and TRAPPC3-like proteins. Here, we take a structural approach to assess the relatedness of these eukaryotic-like proteins in Asgard archaea, the closest known prokaryotic relatives to eukaryotes. We find that the Asgard archaea GTPase core domains closely resemble eukaryotic Rabs and Rags. Asgard archaea roadblock, longin and TRAPPC3 domain-containing proteins form dimers similar to those found in the eukaryotic TRAPP and Ragulator complexes. We conclude that the emergence of these protein architectures predated eukaryogenesis, however further adaptations occurred in proto-eukaryotes to allow these proteins to regulate distinct internal membranes.
On the Consistent Construction of Forced-Choice Ipsative Tests
Authors: Vaughan Martin Paul , Demes Kali A , Glowinkowski Steve Paul
Published: February 2024

The need for consistent construction of forced-choice ipsative tests to avoid the introduction of hard-coded ‘errors-by-design’ is highlighted. A set of necessary criteria for consistent construction, apparently widely overlooked in the literature, is found and recommended. It is shown that for ipsative tests involving P scales with more than M = 2 items per question block, the consistent combinations of P and M are in fact few and far between for tests with a manageable number of item blocks. The introduction of errors through badly designed scoring methods is also illustrated and explained via analysis.
Warming alters non-trophic interactions in soft bottom habitats
Authors: Laukaityte Simona , Bishop Melanie Jane , Govers Laura Leone , Eriksson Britas D. H. Klemens
Published: February 2024

Though there is mounting evidence that climate warming is altering trophic interactions between organisms, its effects on non-trophic interactions remain relatively undocumented. In seagrass systems, the bioturbating activity of infauna influences annual seagrass growth by influencing seed burial depth and germination success as well as sediment properties. If bioturbation is altered by warming, consequences on seagrass may result. Here, we assessed how heatwaves alter seagrass seed burial depth and germination rates when no bioturbators (control), single bioturbators and mixtures of bioturbators of contrasting feeding activities are present. The three bioturbators manipulated were surface (top 1-2cm of sediment) biodiffusor, the brown shrimp (Crangon crangon), the shallow (top 3–8 cm) diffusor, the common cockle, (Cerastoderma edule) and the upward (5–15 cm) conveyor, the polychaete, Cappitellidae spp. We applied two temperature treatments: (1) a present-day scenario set at the average summer temperature of seagrass habitat (17ºC); and (2) a heat-wave scenario modeled on the maximum recorded temperature (26.6ºC). Under present-day conditions, seed burial was greater in the presence of bioturbators than the control where no infauna was added. Cockles had the greatest impact on seed burial among all the bioturbators. Under the heat-wave scenario, seed burial in the mixed bioturbator treatment increased to match that of the cockle treatment. Cockles and polychaetes elevated the germination rates of buried seeds under present-day temperature, but not under the heat-wave scenario. Overall, these results indicate that heatwaves have the potential both to amplify and disrupt non-trophic interactions, with implications for seagrass seed germination.
The apelinergic system accelerates skin repair of full-thickness excisional wounds in a diabetic murine model
Authors: Geraldes Pedro , Robillard Stéphanie , Théroux Léa , Lemay Ariane , Ouellet Marike , Lizotte Farah , Boudreault Pierre-Luc
Published: February 2024

Introduction: Chronic wounds are a serious complication of diabetes. Multiple components in the healing process are impaired by diabetes, creating hard-to-heal or non-healing wounds, increasing the risk of infection, enlargement and amputation. Altered angiogenesis is a major contributor of delayed healing process in diabetic wounds. The apenilergic system (APJ/Apelin/ELABELA) is an activator of the angiogenic response in endothelial cells, and apelin treatment has been shown to improve vascular density in animal models of ischemia. This study explored the impact of Pyr-apelin-13 and Pyr-ELABELA-32 on wound healing processes in diabetic mice and on fibroblast function.
Methods: Two full-thickness excisional wounds were created on the mid-back of nondiabetic and diabetic mice. Diabetic mice received topical application of Pyr-apelin-13 or Pyr-ELABELA-32 daily for 14 days, and wounds were individually photographed to measure global wound closure and healing process. In vitro, fibroblasts were exposed to normal (NG) or high glucose (HG) levels and hypoxia. Cell migration and proliferation assays were performed following either Pyr-apelin-13 or Pyr-ELABELA-32 stimulation.
Results: Fourteen days post-injury, global wound closure was improved in diabetic mice receiving Pyr-apelin-13 or Pyr-ELABELA-32 compared to untreated diabetic mice. Wound treatment with Pyr-apelin-13 and Pyr-ELABELA-32 improved re-epithelialization and angiogenesis, reduced inflammation and promoted collagen synthesis in diabetic scar tissue. In cultured fibroblasts, Pyr-apelin-13 and Pyr-ELABELA-32 stimulation induced cell migration and proliferation through Akt and ERK signaling pathways under both NG or HG concentrations and hypoxia exposure.
Conclusion: Our results demonstrated the therapeutic potential of the endogenous ligands of APJ, apelin and ELABELA, for the treatment of diabetic wounds.
Quantifying CMIP6 Data Accuracy: A Comprehensive Analysis Using Multiple Metrics for the Whole India Grid Region to Identify Optimal Climate Models
Authors: Tiwari Suraj
Published: February 2024

The efficacy of the climate model in forecasting temperature measurements iscarefully examined in this work, with a particular emphasis on the impact of biascorrection and model-specific characteristics. The Mean Bias Error (MBE) analysesshow a consistent pattern: for both highest (Tmax) and minimum (Tmin)temperatures, positive MBE values suggest overestimation and negative valuesimply underestimating of recorded temperatures. This shows that MBE valuesand model accuracy are positively correlated, especially when it comes totemperature extreme prediction. Examining the linear relationship fol- lowingthe bias adjustment reveals different effects on correlation strength. A modestpositive connection is maintained by certain models, such as IPSL-CM6ALR,whereas a significant positive association is maintained by others. Nuancedinsights are revealed by skill scores and Root Mean Square Error (RMSE)computations, which show consistent pre-correction skill ratings among models.After rectification, there is a slight improvement in skill ratings. EC-Earth3 andAWI-CM-1-1-MR regularly show the lowest RMSE values, indicating better performance,particularly when it comes to portraying Tmax. This refined studyconcludes by highlighting the complex relationship between bias correction andspecific model properties and the performance of climate models. Both EC-Earth3and AWI-CM-1-1-MR consistently show themselves to be reliable predictors oftemperature extremes.
The Spatial Effect of Low-Carbon Development of Regional Industries Driven by the Digital Economy: Evidence from Chinese Cities
Authors: Zhang Tian , ZHANG TIAN
Published: February 2024

Utilizing data that encompass municipalities and regions within China at the prefectural level and beyond, spanning the period from 2012 to 2021, this study employed the spatial Durbin model to assess the spatial spillover impact of the digital economy in propelling low-carbon advancement within regional physical industries. This investigation elucidates the spatial spillover mechanism that underlies the low-carbon evolution of regional industries catalyzed by the digital economy and offers nuanced insights. The findings delineate the following observations: (1) The digital economy propels the low-carbon progression of indigenous physical industries and stimulates the low-carbon development of proximate regions’ physical industries through discernible spatial spillover effects. (2) The spatial spillover ramifications of the digital economy manifest a substantive correlation with urban attributes, including geographical positioning, population size, and market integration levels. Notably, municipalities situated in the southeast coastal region, those characterized by larger population sizes, and those exhibiting heightened market integration levels show greater spatial spillover effects attributable to the digital economy. (3) The safeguarding of intangible asset equity property, a pivotal institutional underpinning for fostering digital economic development, amplifies the spatial spillover effect of the digital economy in propelling low-carbon development within regional industries. (4) As geographical and spatial distances expand, the spatial spillover effect of the digital economy attenuates, indicating a diminishing influence with increasing spatial separation.
Rutin attenuates the alcohol withdrawal-induced depressive like behaviour in rats
Authors: Mali Prashant , Bandawane Deepti
Published: February 2024

The presence of rutin in Schinus molle elicited antidepressant-like effects by enhancing the availability of serotonin and noradrenaline in the synaptic cleft. Thus, the main objective of the present study was to explore the antidepressant potential of rutin and its probable underlying mechanism(s) in alcohol withdrawal-induced depression-like behavior in rats. Depressive behaviors were induced by subjecting the rats to ethanol-dependent withdrawal syndrome. The rats were administered varying concentrations of alcohol for 21 days, and withdrawal symptoms were investigated. The animals were administered vehicle, fluoxetine, or rutin for 7 days. Animals were observed for depressive-like state via helplessness, which was reflected as an increase in immobility time in the forced swim test and tail suspension test. Various biochemical alterations, including serum corticosterone levels; endogenous antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH); and lipid peroxidation, in terms of malondialdehyde (MDA) formation in the brain, were studied. The experimental findings demonstrated that rutin elicited a significant reduction in immobility time and prevented the decrease in SOD, CAT, and GSH levels in alcohol withdrawal-induced depressive-like behaviour. Furthermore, to substantiate these findings, our histopathological studies corroborated that rutin ameliorated brain alterations due to stress mediated by alcohol withdrawal. Thus, rutin attenuated depressive-like behaviour through amelioration of oxidative stress by restoration of SOD, GSH, and CAT levels and attenuation of corticosterone, MDA, and NO levels.
Detecting phytoestrogens and mammalian estrogens in blackcurrants (Ribes nigrum L.)
Authors: Nanashima Naoki , Horie Kayo , Maeda Hayato , Kato Yoji
Published: February 2024

Phytoestrogens are estrogen-like molecules found in various plants. Menopausal women experience various menopausal symptoms due to reduced estrogen secretion. The ingestion of phytoestrogens is known to alleviate these symptoms. Blackcurrant (Ribes nigrum L.) is a fruit rich in phytochemicals, including anthocyanins. Blackcurrant extract (BCE) and anthocyanins have phytoestrogenic effects. Although BCE has stronger phytoestrogenic activity than blackcurrant anthocyanins, this aspect has not been explored. BCE likely contains phytoestrogens other than anthocyanins. In this study, the components of blackcurrant fruits were comprehensively investigated through metabolome analysis. In addition to phytoestrogens, such as naringenin, daizein, and resveratrol, mammalian estrogens, such as estrone and β-estradiol, were detected in blackcurrant fruits. An ultrasensitive estrogen measurement analysis revealed that BCE contains approximately 40.2 and 24.5 pg/g of estrone and β-estradiol, respectively, corresponding to approximately 100 times the estrogen content in blackcurrant fruits. We report for the first time that blackcurrant contains phytoestrogens and mammalian estrogens.
Allostatic Load as a Predictor of Postoperative Complications in Patients with Breast Cancer
Authors: Obeng-Gyasi Samilia , Chen JC , Elsaid Mohamed , Handley Demond , Anderson Lisa , Andersen Barbara , Carson William , Beane Joal , Kim Alex , Skoracki Roman , Pawlik Timothy
Published: February 2024

BACKGROUND Allostatic load (AL) is a biological measure of cumulative exposure to socioenvironmental stressors (e.g., poverty). This study aims to examine the association between allostatic load (AL) and postoperative complications (POC) among patients with breast cancer.METHODS Assigned females at birth ages 18 + with stage I-III breast cancer who received surgical management between 01/01/2012-12/31/2020 were identified in the Ohio State Cancer registry. The composite AL measure included biomarkers from the cardiovascular, metabolic, immune, and renal systems. High AL was defined as composite scores greater than the cohort’s median (2.0). POC within 30 days of surgery were examined. Univariable and multivariable regression analysis examined the association between AL and POC.RESULTS Among 4,459 patients, 8.2% had POC. A higher percentage of patients with POC were unpartnered (POC 44.7% vs no POC 35.5%), government-insured (POC 48.2% vs no POC 38.3%) and had multiple comorbidities (POC 32% vs no POC 20%). Patients who developed POC were more likely to have undergone sentinel lymph node biopsy followed by axillary lymph node dissection (POC 51.2% vs no POC 44.6%). High AL was associated with 29% higher odds of POC (aOR 1.29, 95% CI 1.01–1.63). A one-point increase in AL was associated with 8% higher odds of POC (aOR 1.08, 95% CI 1.02–1.16) and a quartile increase in AL was associated with 13% increased odds of POC (aOR 1.13, 95% CI 1.01–1.26).CONCLUSION Among patients undergoing breast cancer surgery, increased exposure to adverse socioenvironmental stressors, operationalized as AL, was associated with higher odds of postoperative complications.
Fmoc-FF hydrogels and nanogels for improved and selective delivery of Dexamethasone in leukemic cells and diagnostic applications
Authors: Gallo Enrico , Diaferia Carlo , Smaldone Giovanni , Rosa Elisabetta , Pecoraro Giovanni , Morelli Giancarlo , Accardo Antonella
Published: February 2024

Dexamethasone (DEX) is a synthetic cortisol used for the treatment of different pathological states, thus comprising cancer, ocular disorders, and COVID-19 infection. Its clinical use is hampered by the low solubility and severe side effects related to its systemic administration. The capability of peptide-based nanosystems, like hydrogels (HGs) and nanogels (NGs), to serve as vehicles for the passive target of active pharmaceutical ingredients and the selective internalization into leukemic cells has been demonstrated. Peptide based HG loaded with DEX were formulated via the “solvent-switch” method, using Fmoc-FF homopeptide as building block. Due to the tight interaction of the drug with the peptidic matrix, a significant rigidification of the gel (G’ = 67.9 kPa) was observed. The corresponding injectable NG, obtained for submicronization of the HG in the presence of two stabilizing agents (TWEEN®60 and SPAN®60, 48/52 mol/mol), were found to be stable at least up to 90 days with a mean diameter of around 105 nm. NG does not exhibit hemolytic effect on human serum and is selectively internalized by RS411 leukemic cells, passively target leukemic cells over healthy PBMCs, paving the way for the generation of new diagnostic strategies targeting onco-hematological diseases.