bluuebunny/crossref_metadata_2025 huggingface dataset:
Produção integrada de tambaqui com hortaliças em residência urbana
Authors: Oliveira Graziele Felix de , Foroni Isis Lazzarini , Oliveira Marcos Antonio de
Published: June 2022

A aquaponia surge como uma alternativa para produção de alimento, a qual é gerida pelo princípio da produção sustentável, com uma visão de respeito ao meio ambiente e atendimento as atuais demandas de um mercado consumidor mais consciente e exigente. Essa técnica de produção se refere à integração entre a criação de peixes, e o cultivo de vegetais e/ou hortaliças hidropônicas. O presente estudo teve como objetivo demonstrar de maneira clara e objetiva para a população a possibilidade de produzir peixes e hortaliças em pequenos espaços, principalmente nos centros urbanos. A espécie de peixe modelo foi o tambaqui (Colossoma macropomum) e as hortaliças modelos foram a alface (Lactuca sativa), a rúcula (Eruca vesicaria ssp. Sativa), o almeirão (Cichorium intybus sub sp. Intybus) e o agrião (Nasturtium officinale). Os dados coletados mostraram bons resultados quanto ao crescimento dos peixes e das hortaliças, trazendo informação sobre o desenvolvimento e cultivo em sistemas aquapônicos urbanos de baixo custo. Acreditamos que esses resultados serão de grande valia para a população em geral e que os mesmos possam aumentar o interesse nessa modalidade de produção de alimentos saudáveis e com baixo custo.
Papel das equipes multiprofissionais diante idosos vítima de violência
Authors: Souza Lizandra Ellem Silva de , Farias Anderson Fernandes de Carvalho , Defante Maria Luiza Rodrigues , Rodrigues Mendonça Vinícius , Xavier Ana Luisa de Melo , Sousa Cássio Moura de , Santos Dulcicleide Rodrigues , Apolinário Joelma Maria dos Santos da Silva , Siqueira Pammera Morais , Costa Caroline Lopes
Published: June 2022

A violência contra o idoso ocorre de forma frequente, principalmente por membros da família, se tornado uma grande problemática da área da saúde e necessitando de uma atenção especial. O presente estudo tem como objetivo identificar os cuidados em conjunto realizados pelos profissionais da saúde em situações de violência contra o idoso. Trata-se de uma revisão integrativa da literatura com uma abordagem qualitativa. O período de busca ocorreu no mês de maio de 2022. Onde foi realizada uma busca de artigos nas bases de dados Scientific Electronic Library Online (SCIELO), google acadêmico e o que está presente no estatuto do idoso. Utilizando os Descritores em Ciências da Saúde (DeCS) e Operadores Boleanos na respectiva sequência “Idoso AND Violência AND Equipes de saúde “. Foram utilizados critérios de elegibilidade para melhor se obter os artigos que abordassem a temática de interesse. Após isso realizou-se uma leitura do título e objetivo dos estudos. Após aplicação dos critérios de inclusão e exclusão, restaram 76 artigos que foram analisados. Sendo destes, 62 excluídos por não se encaixarem no foco da pesquisa, restando 10 artigos. Os estudos apontaram que os profissionais que compõem as equipes multiprofissionais de saúde são essenciais na identificação de casos de violência, pois tem proximidade com os pacientes e apesar das dificuldades encontradas podem intervir no combate a esses casos contribuindo na devolução da qualidade de vida dessas pessoas.
A análise do conceito “avaliação em saúde” na perspectiva evolucionária de Rodgers
Authors: Maia Kariny Kelly de Oliveira , Alves Erta Bezerra da Silva , Lopes Rayssa Horacio , Salvador Pétala Tuani Candido de Oliveira , Oliveira Lannuzya Verissimo e
Published: June 2022

Objetivo: analisar o conceito “avaliação em saúde” nas produções científicas brasileiras na perspectiva evolucionária de Rodgers. Método: estudo descritivo, realizado a partir do método evolucionário de Rodgers. A coleta de dados ocorreu em setembro de 2020 no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Os dados quantitativos foram analisados a partir de estatística descritiva simples e os conceitos com o suporte do IRAMUTEQ. Resultados: a amostra foi composta por 49 estudos, predominantemente dissertações produzidas por enfermeiros, nos anos de 2016 e 2017. Os antecedentes, atributos e consequentes do conceito analisado estavam presentes em 93,9% dos estudos avaliados. Os termos substitutos e os conceitos relacionados foram identificados em 18,4% e 77,5% dos estudos, respectivamente. Considerações Finais: este conceito relaciona-se à gestão da saúde a partir de julgamentos com critérios bem estabelecidos, tomadas de decisões e intervenções nos processos de trabalho em saúde. A análise deste conceito permite suporte para consolidação do conhecimento e aperfeiçoamento dos processos de trabalho que o utilizam.
Risco radioativo no sudoeste da Bahia, Brasil: um mapeamento das ações institucionais
Authors: Gomes Rita de Cassia Lopes , D’Arede Cláudia Oliveira , Rêgo Marco Antônio Vasconcelos , Carvalho Fernando Martins , Pena Paulo Gilvane Lopes
Published: June 2022

Objetivou-se apresentar e discutir as ações das instituições públicas para controle do risco radioativo decorrente da mineração de urânio, entre 2008 e 2019, no sudoeste do Estado da Bahia, Brasil. Trata-se de estudo qualitativo de caso múltiplo. Analisou-se 141 documentos produzidos pelas instituições e 28 entrevistas com gestores e técnicos das instituições. Foram interpretados a partir do modelo da CDC/EUA/OMS para análise das Funções Essenciais em Saúde Pública, por meio e aproximações com a Hermenêutica. Os resultados revelaram: 1 - situações de contrastes institucionais com diferentes visões sobre a saúde e o meio ambiente diante do problema; 2 - que existem modelos de gestão e experiências diferenciadas frente ao mesmo fenômeno; 3 - que as narrativas institucionais expressaram consensos em termos de baixa capilaridade e capacidade técnica limitada das ações para o controle do risco radioativo 4 - baixa qualificação dos profissionais de saúde e condições técnicas para prevenção e controle do risco radioativo; 5 - informações epidemiológicas insuficientes sobre risco radiativo. Conclui-se que as instituições de saúde e ambiente analisadas não apresentam capacidade para o controle do risco radioativo no sudoeste da Bahia.
Estilos de vida de pessoas com adoecimento crônico a fibromialgia em tempos de pandemia do Coronavírus
Authors: Albuquerque Nadja Maria Queiroz de , Berardinelli Lina Márcia Miguéis , Lopes Jéssica Rodrigues , Santos Matheus de Albuquerque , Batista Deise Breder dos Santos , Dantas Maria Eunice Amaral , Santos Mauro Leonardo Salvador Caldeira dos , Pacheco Sandra Teixeira de Araújo
Published: June 2022

Este estudo foi realizado com o objetivo de identificar na literatura como está sendo discutidos por profissionais de saúde os hábitos e os estilos de vida de pessoas que vivenciam o adoecimento crônico a fibromialgia e as repercussões diante da situação de pandemia pelo coronavírus. Trata-se de uma revisão integrativa da literatura que incide na realização de uma síntese dos artigos e a junção deles sobre a temática pesquisada; para o levantamento bibliográfico utilizou-se o fluxograma guiada pelo (PRISMA), compuseram a amostra final 10 artigos. As temáticas mais relevantes encontradas nos artigos foram, doenças crônicas, dimensões do cuidado humano, empoderamento de mulheres com fibromialgia, estilo de vida saudável, fibromialgia relacionado a atividade física, depressão e qualidade de vida, Covid-19 e doenças crônicas. Conclui-se que a adoção de bons hábitos contribui para a redução da probabilidade de a doença chegar a esse grupo de pessoas vulneráveis, com a pandemia da Covid-19 esses hábitos foram alterados desafiadoramente, exacerbando as emoções e ansiedades por conta da fibromialgia, acarretando prejuízos no tratamento e na dinâmica familiar. Além de contribuir para o sedentarismo, aumento do consumo de alimentos ultra processados e alto valor calórico, resultando em prejuízos para a saúde das pessoas. Sugere-se a implementação de políticas públicas que promovam atos de acessibilidade à saúde, com acolhimento e medidas preventivas a toda a população.
Esgotamento profissional na docência: Síndrome de Burnout em professores universitários durante a pandemia da COVID-19
Authors: Silva-Barbosa Carlos Eduardo da , Lima Edna Pinto Medeiros de , Costa Yasmim Xavier Arruda , Lima Valéria Fernandes da Silva , Carvalho Socorro Taynara Araújo , Rocha André Sousa
Published: June 2022

Introdução: A Síndrome de Burnout (SB) surgiu na década de 1970, sendo caracterizada por três componentes: exaustão emocional, despersonalização e baixa realização profissional. Objetivo: Investigar, por meio da literatura, quais são os fatores associados à Síndrome de Burnout em docentes durante a pandemia da COVID-19. Método: Revisão integrativa da literatura, de abordagem qualitativa, de natureza exploratória e descritiva. O levantamento nas bases de dados foi efetuado na MEDLINE e LILACS, por intermédio da BVS, e na LATINDEX, acessada pelo Portal de Periódicos da Capes. Os descritores utilizados foram: “burnout”, “docentes” e “COVID-19”, cruzados pelo operador booleano AND. Foram incluídos estudos primários, disponíveis com textos completos, entre 2020 a 2021, nos idiomas espanhol, inglês e português do Brasil. Foram excluídos estudos de revisão, estudos não avaliados por pares, artigos duplicados nas bases de dados, artigos incompletos, pesquisas que fugissem da temática e do objetivo deste trabalho. Resultados e discussão: Inicialmente, foram encontrados 22 artigos. Sendo 21 selecionados para análise, onde seis compuseram a revisão final. Os principais fatores relacionados a SB foram o excesso de atividades fora da sala de aula, aumento de reuniões, falta de treinamento, condições inadequadas relacionadas ao trabalho, excesso de cobrança, transformar o ambiente familiar em local de trabalho, dividir o computador com outros membros da família, entre outros. Considerações Finais: É essencial que ações sejam desenvolvidas, a fim de garantir a satisfação profissional dos professores, seja por meio de acompanhamento psicológico ou por intermédio de atividades que auxiliem a satisfação profissional nas instituições de ensino.
Pemanfaatan Software Tableau Dalam Pembuatan Dashboard Bencana Karhutla Di BPBD Sumatera Selatan
Authors: Widayati Qoriani , Effendi Irman
Published: June 2022

Masalah kebakaran hutan dan lahan di Indonesia sudah menjadi bencana rutin tahunan. Pada setiap tahunnya beberapa provinsi di Indonesia mengalami kebakaran hutan dan lahan, walaupun angka rendah dan tingginya penyebaran titik api sesalu berbeda pada setiap tahunnya. Di Indonesia sendiri terdapat beberapa provinsi yang rawan kebakaran hutan dan lahan. Pada rentan waktu 15 tahun terakhir, sebagian besar kebakaran hutan di Indonesia terjadi di Sumatera Selatan, Kalimantan Tengah dan Riau. Badan Penanggulangan Bencana Daerah (BPBD) Provinsi Sumatera Selatan, sebagai unsur pelaksana pemerintah provinsi di bidang Penanggulangan Bencana, mengemban tugas dan tanggung jawab mewujudkan penyelenggaraan penanggulangan bencana yang terencana, terpadu, terkoodinasi dan menyeluruh. Melihat beberapa fungsi serta peranan dari BPBD yang sangat penting dalam hal Penanggulangan Bencana Daerah, untuk itu diperlukan sebuah executive information system (IES) yang dapat memberikan tampilan informasi tentang kondisi bencana yang terjadi di provinsi sumatera selatan khususnya dalam hal kebakaran hutan dan lahan. Berdasarkan penjelasan di atas maka penulis akan membuat dashboard yang secara umum memiliki tampilan yang sesuai serta cukup dimengerti oleh pihak executive dalam pembuatan dashboard maka penulis menerapkan bussines intelligence yang dapat memberikan solusi tebaik dalam perolehan data dari berbagai sumber dan mengelolanya untuk keperluan pengambilan keputusan. Dalam pembuatan dashboard dibutuhkan sebuah bantuan aplikasi yaitu software tableau. Metode yang digunakan dalam pengabdian ini adalah memberikan pelatihan dan pendampingan.
Penyuluhan Internet Sehat Pada SMK Negeri 1 Tanjung Lubuk Kabupaten Ogan Komering Ilir (OKI) Sumatera Selatan
Authors: Agustina Merry , Widayati Qoriani , Rizal Syahril
Published: June 2022

Seperti kita ketahui bahwa saat ini internet dapat dengan mudah diakses oleh setiap orang. Dengan internet dapat membawa orang ke mana saja hanya dengan satu klik. Namun karena kemudahan ini, dengan penggunaan internet yang tidak cermat dan tidak sehat pastinya dapat memberikan dampat negatif yang cukup besar. Remaja merupakan salah satu pengguna internet dengan semangat belajar dan rasa ingin tahu yang tinggi. Namun yang terjadi ada banyak penggunaan internet di kalangan remaja yang memberikan dampak negatif. Hal ini terjadi karena kurangnya pengetahuan remaja terhadap penggunaan yang baik dan cerdas atau penggunaan internet secara sehat. Kondisi ini terjadi dapat juga disebabkan kurangnya penjelasan dan edukasi terkait internet kepada para remaja. Oleh karena itu peran orang tua, guru dan masyarakat dalam membantu memberikan penjelasan, edukasi sebagai pemahaman kepada remaja tentang internet sangatla penting. Salah satu bentuk kegiatan edukasi tersebut adalah dengan dilakukannya Penyuluhan Internet Sehat Bagi para siswa. Karena dengan adanya kegiatan pengabdian berupa penyuluhan maka akan terjadi proses menjelaskan, memberika pemahaman dan tanya jawab tentang internet sehat, sehingga  memberikan manfaat dengan meningkatnya pemahaman tentang internet sehat dan bijaksana sehingga meningkatnya dampat positif dan meminimalkan dampak negatif dari berinternet dan pada akhirnya tercipta remaja yang cerdas, kreatif dan produktif.
Pengembangan Kurikulum Merdeka Belajar Kampus Merdeka (MBKM) Program StudiPendidikan Olahraga Strata Satu (S1) Fakultas Keguruan Ilmu Pendidikan dan Bahasa Universitas Bina Darma
Authors: Endrawan I Bagus , Hardiyono Bayu , Satria M Haris , Kesumawati Selvi Atesya
Published: June 2022

Pengabdian yang diberikan kepadamahasiswa khususnya pendidikan olahragainibertujuanuntukmemfasilitasi program studi untuk mengembangkan kurikulum sesuai dengan kebijakan MBKM dan mendorong program studi untuk melaksanakan kerja sama dengan mitra dalam rangka implementasi kurikulum program MBKM. Metode pelaksanaan dalamkegiatanpengabdianini adalah Focus Group Discusion (FGD) membahas mengenai pengenalan dan pelaksanaan Merdeka Belajar Kampus Merdeka (MBKM) di Universitas Bina Darma pada Program Studi Pendidikan Olahraga melalui aplikasi Zoom Meeting. Luaran yang diharapakan dalamkegiatanpengabdianini adalah:

(1) Dokumen laporan hasil penyusunan kurikulum program studi yang mendukung program MBKM termasuk prosedur konversi dan pengakuan kredit, (2) Publikasi di Jurnal Pengabdian KepadaMasyarakat.
MODEL PENYELESAIAN SENGKETA DAN PERKARA PIDANA IN AND OUT SIDE COURT
Authors: Amalia Reva
Published: June 2022

This study aims to explain the dispute resolution in and out side court (Litigation and Non-Litigation Dispute Resolution) based on the existence of a dispute or criminal case between communities that fight for certain main goals from each party, and put pressure on each other. the other then failed to reach a single opinion and each side tried to consciously fight for their main goals. Which ultimately creates a conflict or dispute that must be resolved both litigation and non-litigation. So that this research can be formulated, namely, related to what is meant by litigation and non-litigation dispute resolution. What is the difference between mediation in litigation and non-litigation dispute resolution, and how to resolve criminal cases outside the court. The purpose of this study is to find out what is meant by litigation and non-litigation dispute resolution and the differences and how to resolve the case or dispute outside the court. This research method uses a normative qualitative method, the results of which conclude that: Litigation dispute resolution is a settlement process carried out in court, while non-litigation is a dispute resolution process outside the court. The process of resolving criminal cases outside the court can be carried out by way of deliberation.
MAKNA SAKINAH DALAM SURAT AL-RUM AYAT 21 MENURUT M. QURAISY SYIHAB DALAM TAFSIR AL-MISHBAH DAN RELEVANSINYA DENGAN TUJUAN PERKAWINAN DALAM KOMPILASI HUKUM ISLAM
Authors: Putra Kurlianto Pradana , Suprihatin Suprihatin , Wastoni Oni
Published: June 2022

That the Qur’an as a holy book, is believed to be eternal, universal and true. The Qur’an is the main source of Islamic teachings and a way of life for every Muslim. The Qur’an not only contains instructions about the relationship between humans and God, but also regulates human relations with each other (hablum min Allah wa hablum min an-nas), as well as humans with the natural surroundings. Among the issues related to hablum min an-nas discussed in the Qur’an is happiness in marriage as revealed in Surah Al-Rum Verse 21. Happiness in marriage will be expressed through the thoughts of M. Quraish Shihab through the book Tafsir al-Mishbah to reveal the legal aspects. The research was conducted using a library or normative method. While the research data uses secondary data consisting of primary legal materials from the Tafsir al-Misbah book, secondary legal materials such as the Compilation of Islamic Law, and tertiary materials such as dictionaries. Rum verse 21 according to M. Quraish Shihab. The results of this study indicate that in the view of M. Quraish Shihab the word sakinah means calm that is preceded by dynamic turmoil. The expression of sakinah by using the sentence “litaskunu ilaiha” shows the purpose of realizing the tendency to calm down between husband and wife. In the interpretation of al-Mishbah, it shows that there is a tendency that the litaskunu sentence in Surah Al-Rum Verse 21 uses lam ta’lil which contains a tendency or purpose. Applicatively lam ta’lil in the word litaskunu in surah al-Rum verse 21, contains dalalah (guidance) ibarah whose meaning is easy to understand from the text, namely so that there is a tendency to calm down. Thus, in the meaning of sakinah in Surah Al-Rum verse 21, it is found that the tendency of sakinah in a partner must be used as the goal of acting in marriage. This research has relevance to the purpose of marriage in the compilation of Islamic law, as stated in article three of the Compilation of Islamic Law
ANALISISPENGARUH PEMBIAYAAN MURABAHAH TERHADAP OMZET UMKM (STUDI KASUS PADA PT BPRS HARTA INSAN KARIMAH CABANG CIKARANG)
Authors: Mursidah Erisma Venny , Rahmawati Rafika , Widyananto Arief
Published: June 2022

This study aims to analyze the effect of murabahah financing at BPRS Harta Insan Karimah Cabang Cikarang branch on changes in turnover of micro, small and medium enterprises and to find out how big the difference in customer turnover before and after receiving murabahah financing. The research methodology used is a quantitative approach. The sampel used is micro, small and medium-sized financing customers of BPRS Harta Insan Karimah Cabang Cikarang branch in 2018 as many as 70 respondents with various types of businesses. The results of this study indicate that partial murabahah financing has a positive and significant effect between the variables of murabahah financing on micro, small and medium enterprises turnover
Потенциал использования цифровых информационных моделей в рамках управления строительством
Authors: АЛЕКСАНИН Александр Вячеславович , ЖАРОВ Ярослав Владимирович
Published: June 2022

В последние годы увеличивается число выданных положительных заключений экспертизы и разрешений на ввод объектов в эксплуатацию и объемы вовлекаемых в строительное производство ресурсов в денежном эквиваленте и т. д. При этом возрастают объемы доступной информации, получаемой на всех этапах жизненного цикла инвестиционно-строительного проекта, повышаются требования к качеству проектирования объектов капитального строительства. Это обусловливает создание методик работы с накапливаемым массивом данных и внедрение информационных технологий в процессы проектирования. Потенциал применения технологии информационного моделирования может быть реализован в том числе благодаря систематизации информации на основе цифровых информационных моделей объектов капитального строительства. В работе предлагается использование строительной цифровой информационной модели объекта капитального строительства на этапе реализации инвестиционно-строительного проекта, что позволит обеспечить необходимую степень интеграции с процессами управления. Показаны положительные практические результаты, которые были достигнуты с использованием цифровых информационных моделей в рамках системы управления строительством.
Интегрированные типы промышленных зданий с использованием ветроэнергетических установок
Authors: ФИНОГЕНОВ Александр Иванович
Published: June 2022

Рассмотрена актуальная проблема расширения применения альтернативных источников возобновляемой энергии при строительстве и реконструкции промышленных объектов. В качестве основной концепции энергосбережения предложено использование энергетического потенциала приземных воздушных ветровых потоков с одновременным формированием ветроактивного типа профиля производственного здания. Методика интеграции ветроэнергетических установок в структуру многопролетного здания проиллюстрирована на примерах производственных объектов, предназначенных для строительства и реконструкции. В работе показаны принципиальные проектные решения, обеспечивающие эффективное размещение в единой схеме несущего каркаса комплекса дополнительной ветровой электростанции с применением ветровых турбин. Рекомендуемые решения основаны на использовании современных патентных разработок. Особенностью компоновки ветровых турбоагрегатов является их конструктивное исполнение в виде многорядных однотипных секций, устанавливаемых в верхних габаритах пролетов производственного здания. Результаты исследований показывают возможность нового подхода к созданию энергоэффективных типов производственных зданий различного назначения. Обоснована перспективность проведения дальнейших комплексных исследований в области методики проектирования и строительства энергоэффективных типов промышленных зданий.
Расчет стеклянных прогонов покрытия двора здания бывшего Главного штаба
Authors: ВЕДЯКОВ Иван Иванович , ФАРФЕЛЬ Михаил Иосифович , РОЖКОВА Лидия Сергеевна
Published: June 2022

Проект реконструкции и реставрации внутреннего двора № 4 восточного крыла здания бывшего Главного штаба в Санкт-Петербурге предусматривал использование в покрытии двора стеклянных балок в качестве прогонов для кровли из светопрозрачных конструкций. Внутренний двор предназначался для размещения в нем экспонатов Государственного Эрмитажа. При проведении экспертизы специалисты ЦНИИСК им. В. А. Кучеренко выполнили подробные расчеты с определением несущей способности и деформативности всех применяемых в покрытии конструкций. Было установлено, что проектное решение не обеспечивает общую устойчивость каркаса покрытия. На основании результатов расчета каркаса, предложенного в проекте, было рекомендовано ввести систему связей и установить алюминиевые балки и прогоны вместо стеклянных балок. Приведены эпюры внутренних усилий, проведена проверка несущей способности, включая проверку общей устойчивости конструкции, показаны деформированные схемы конструкции.
Расчетные величины пожарного риска при авариях на наружных газопроводах
Authors: ГЛУХАНОВ Александр Сергеевич , ЦАПЛИН Виталий Васильевич
Published: June 2022

Рассмотрен подход к определению значения условной вероятности поражения человека, находящегося в определенной точке селитебной территории, в результате развития пожароопасных ситуаций на сетях газораспределения, связанных с их разрушением и последующим воспламенением газа. На основе анализа причин возникновения аварий и факторов, определяющих их исход, а также учитывая особенности технологических процессов транспортировки природного газа, выделены типовые сценарии аварии. Для каждого сценария установлены значения вероятностей возникновения аварийных ситуаций. Предлагаемый подход позволяет более точно определить значения риска травмирования и гибели людей в результате аварий на наружных газопроводах, расположенных на территории населенных пунктов. Сделан вывод о том, что если расчетное значение риска аварий на газопроводе превышает значение, установленное нормативными документами, то в проекте должны быть дополнительно предусмотрены меры по повышению безопасности газораспределительных сетей.
Прогнозирование жизненного цикла дорожных одежд нежесткого типа
Authors: КЛЕКОВКИНА Мария Петровна , БОНДАРЕВА Эльвира Дмитриевна
Published: June 2022

Представлены материалы исследования теоретического подхода по учету и прогнозированию процессов постепенного накопления остаточных деформаций и повреждений в результате контактирования слоев дорожной одежды и реальных связей элементов, влияющих на неравномерность деформирования, изменения напряженно-деформированного состояния и срока службы. Для эффективного использования финансовых и материально-технических ресурсов при проектировании предложен многоэтапный расчет многослойной дорожной одежды, позволяющий планировать необходимые ремонты дороги в пределах ее жизненного цикла. Приведена методика расчета нежесткой дорожной одежды на стадии разработки проекта дороги, в соответствии с которой в течение жизненного цикла, равного двум срокам между капитальными ремонтами, периодически осуществляется восстановление слоев с битумным вяжущим при обязательном соответствии прочностных показателей требуемому уровню надежности. Использование данной методики позволит обеспечить существенную экономию ресурсов в течение всего жизненного цикла автомобильной дороги.
Ishbāʿ al-maʿnā in the Qur’an: A Structural Survey of Sūrat al-Ḥāqqa (Q. 69)
Authors: ElShafey Mohamed Ibrahim
Published: June 2022

This article seeks to define the meaning of the technical linguistic term ‘ ishbāʿ al-maʿnā’ (‘enhancing the meaning’) and explore how this device helps clarify the linguistic structure of Sūrat al-Ḥāqqa (Q. 69). The Qur’anic text, held to transcend time and space, utilises literary styles and lexical structures to convey its meaning across a diverse range of contexts. In this article the author analyses a selection of verses, all of which are characterised by the presence of ishbāʿ al-maʿnā. Sūrat al-Hāqqa offers a good sample of this category of verses.

The primary research question will be approached via four enquiries and ten investigative points that offer both description and analysis of the occurrence of ishbāʿ al-maʿnā within Sūrat al-Ḥāqqa and the role linguistics plays in this phenomenon throughout the sura, which focuses primarily on the Day of Judgement.
FRCNet: Feature Refining and Context-Guided Network for Efficient Polyp Segmentation
Authors: Shi Liantao , Wang Yufeng , Li Zhengguo , Qiumiao Wen
Published: June 2022

Colorectal cancer, also known as rectal cancer, is one of the most common forms of cancer, and it can be completely cured with early diagnosis. The most effective and objective method of screening and diagnosis is colonoscopy. Polyp segmentation plays a crucial role in the diagnosis and treatment of diseases related to the digestive system, providing doctors with detailed auxiliary boundary information during clinical analysis. To this end, we propose a novel light-weight feature refining and context-guided network (FRCNet) for real-time polyp segmentation. In this method, we first employed the enhanced context-calibrated module to extract the most discriminative features by developing long-range spatial dependence through a context-calibrated operation. This operation is helpful to alleviate the interference of background noise and effectively distinguish the target polyps from the background. Furthermore, we designed the progressive context-aware fusion module to dynamically capture multi-scale polyps by collecting multi-range context information. Finally, the multi-scale pyramid aggregation module was used to learn more representative features, and these features were fused to refine the segmented results. Extensive experiments on the Kvasir, ClinicDB, ColonDB, ETIS, and Endoscene datasets demonstrated the effectiveness of the proposed model. Specifically, FRCNet achieves an mIoU of 84.9% and mDice score of 91.5% on the Kvasir dataset with a model size of only 0.78 M parameters, outperforming state-of-the-art methods. Models and codes are available at the footnote.1
Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling
Authors: Kim Hyo-Sung , Hwang Hyun-Jeong , Kim Han-Jun , Choi Yeji , Lee Daehyung , Jung Hong-Hee , Do Sun Hee
Published: June 2022

The mammalian tissue extracellular matrix (ECM) has been used as a scaffold to facilitate the repair and reconstruction of numerous tissues. However, the material properties of decellularized ECM (dECM) from in vitro cell cultures and the effect of these properties on wound remodeling remain unclear. To elucidate its biological activity, we extracted dECM from human lung fibroblasts, fabricated it into a patch, and applied it to a full-thickness skin wound. The fibroblast-derived dECM (fdECM) maintained the content of collagen Ⅰ, collagen Ⅳ, and elastin, and the extraction process did not damage its critical growth factors. The fdECM-conjugated collagen patch (COL-fdECM) facilitated wound contraction and angiogenesis in the proliferative phase when applied to the in vivo full-thickness skin wound model. Moreover, the COL-fdECM treated wound showed increased regeneration of the epidermal barrier function, mature collagen, hair follicle, and subepidermal nerve plexus, suggesting qualitative skin remodeling. This therapeutic efficacy was similarly observed when applied to the diabetic ulcer model. fdECM was shown to help remodel the tissue by regulating fibroblast growth factors, matrix metalloproteinases, and tissue inhibitors of metalloproteinases via the p38 and ERK signaling pathways in an in vitro experiment for understanding the underlying mechanism. These results provide a biological basis for cell-derived ECM as a multi-functional biomaterial applicable to various diseases.
Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy
Authors: Cong Xiufeng , Chen Jun , Xu Ran
Published: June 2022

Spatially- and/or temporally-controlled drug release has always been the pursuit of drug delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal pathophysiological characteristics of the tumor microenvironment, including acidosis, overexpression of special enzymes, hypoxia, and high levels of ROS, GSH, and ATP, offer the possibility for the design of stimulus-responsive DDSs for controlled drug release to realize more efficient drug delivery and anti-tumor activity. With the help of these stimulus signals, responsive DDSs can realize controlled drug release more precisely within the local tumor site and decrease the injected dose and systemic toxicity. This review first describes the major pathophysiological characteristics of the tumor microenvironment, and highlights the recent cutting-edge advances in DDSs responding to the tumor pathophysiological environment for cancer therapy. Finally, the challenges and future directions of bio-responsive DDSs are discussed.
Intensifying Continuous Production of Gag-HA VLPs at High Cell Density Using Stable Insect Cells Adapted to Low Culture Temperature
Authors: Fernandes Bárbara , Correia Ricardo , Alves Paula M. , Roldão António
Published: June 2022

Protein production processes based on stable insect cell lines require intensification to be competitive with the insect cell-baculovirus expression vector system (IC-BEVS). High cell density (HCD) cultures operate continuously, capable of maintaining specific production rates for extended periods of time which may lead to significant improvements in production yields. However, setting up such processes is challenging (e.g., selection of cell retention device and optimization of dilution rate), often demanding the manipulation of large volumes of culture medium with associated high cost. In this study, we developed a process for continuous production of Gag virus–like particles (VLP) pseudotyped with a model membrane protein (influenza hemagglutinin, HA) at HCD using stable insect cells adapted to low culture temperature. The impact of the cell retention device (ATF vs. TFF) and cell-specific perfusion rate (CSPR) on cell growth and protein expression kinetics was evaluated. Continuous production of Gag-HA VLPs was possible using both retention devices and CSPR of 0.04 nL/cell.d; TFF induces higher cell lysis when compared to ATF at later stages of the process (kD = 0.009 vs. 0.005 h−1, for TFF and ATF, respectively). Reducing CSPR to 0.01–0.02 nL/cell.d using ATF had a negligible impact on specific production rates (rHA = 72–68 titer/109 cell.h and rp24 = 12–11 pg/106 cell.h in all CSPR) and on particle morphology (round-shaped structures displaying HA spikes on their surface) and size distribution profile (peaks at approximately 100 nm). Notably, at these CSPRs, the amount of p24 or HA formed per volume of culture medium consumed per unit of process time increases by up to 3-fold when compared to batch and perfusion operation modes. Overall, this work demonstrates the potential of manipulating CSPRs to intensify the continuous production of Gag-HA VLPs at HCD using stable insect cells to make them an attractive alternative platform to IC-BEVS.
Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering
Authors: Ao Yunong , Zhang En , Liu Yangxi , Yang Liu , Li Jun , Wang Fuyou
Published: June 2022

Cartilage dysfunctions caused by congenital disease, trauma and osteoarthritis are still a serious threat to joint activity and quality of life, potentially leading to disability. The relatively well-established tissue engineering technology based on hydrogel is a promising strategy for cartilage defect repairing. However, several unmet challenges remain to be resolved before its wide application and clinical translation, such as weak mechanical property and compromised bioactivity. The development of nanomedicine has brought a new dawn to cartilage tissue engineering, and composite hydrogel containing nanoparticles can substantially mimic natural cartilage components with good histocompatibility, demonstrating unique biological effects. In this review, we summarize the different advanced nanoparticle hydrogels currently adopted in cartilage tissue engineering. In addition, we also discuss the various application scenarios including injection and fabrication strategies of nanocomposite hydrogel in the field of cartilage repair. Finally, the future application prospects and challenges of nanocomposite hydrogel are also highlighted.
Why is Mortalin a Potential Therapeutic Target for Cancer?
Authors: Yoon A-Rum , Wadhwa Renu , Kaul Sunil C , Yun Chae-Ok
Published: June 2022

Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of the disease and identify novel targets for the development of better treatment strategies. Mortalin is a member of the heat shock 70 kDa protein family. It is enriched in several types of cancer and contributes to carcinogenesis in various ways, including inactivation of the tumor suppressor p53, deregulation of apoptosis, induction of epithelial–mesenchymal transition, and enhancement of cancer stemness. It has been studied extensively as a therapeutic target for cancer treatment, and several types of anti-mortalin molecules have been discovered that effectively suppress the tumor cell growth. In this review, we 1) provide a comprehensive sketch of the role of mortalin in tumor biology; 2) discuss various anti-mortalin molecules, including natural compounds, synthetic small molecules, peptides, antibodies, and nucleic acids, that have shown potential for cancer treatment in laboratory studies; and 3) provide future perspectives in cancer treatment.
Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland
Authors: Lee May Yin
Published: June 2022

Cancer is characterized as a reversion of a differentiated cell to a primitive cell state that recapitulates, in many aspects, features of embryonic cells. This review explores the current knowledge of developmental mechanisms that are essential for embryonic mouse mammary gland development, with a particular focus on genes and signaling pathway components that are essential for the induction, morphogenesis, and lineage specification of the mammary gland. The roles of these same genes and signaling pathways in mammary gland or breast tumorigenesis and metastasis are then summarized. Strikingly, key embryonic developmental pathways are often reactivated or dysregulated during tumorigenesis and metastasis in processes such as aberrant proliferation, epithelial-to-mesenchymal transition (EMT), and stem cell potency which affects cellular lineage hierarchy. These observations are in line with findings from recent studies using lineage tracing as well as bulk- and single-cell transcriptomics that have uncovered features of embryonic cells in cancer and metastasis through the identification of cell types, cell states and characterisation of their dynamic changes. Given the many overlapping features and similarities of the molecular signatures of normal development and cancer, embryonic molecular signatures could be useful prognostic markers for cancer. In this way, the study of embryonic development will continue to complement the understanding of the mechanisms of cancer and aid in the discovery of novel therapeutic targets and strategies.
Determination of Rare Earth Elements by Inductively Coupled Plasma–Tandem Quadrupole Mass Spectrometry With Nitrous Oxide as the Reaction Gas
Authors: Zhu Yanbei
Published: June 2022

Nitrous oxide (N2O) was investigated as the reaction gas for the determination of rare earth elements (REEs) by inductively coupled plasma–tandem quadrupole mass spectrometry (ICP-QMS/QMS). The use of N2O as the reaction gas apparently improved the yields of mM16O+ for Eu and Yb in the reaction cell. As a result, the sensitivities for measurement of Eu and Yb were apparently improved in comparison to those obtained with O2 as the reaction gas. A high sensitivity measurement of the whole set of REEs was achieved, providing a typical sensitivity of 300,000 CPS mL/ng for REEs measured with an isotope having isotopic abundance close to 100%. The use of N2O as the reaction gas helped suppress Ba-related spectral interferences with the measurement of Eu, permitting the measurement of Eu in a natural sample without mathematic correction of spectral interferences. The detection limits (unit, pg/mL) for 14 REEs (except for Pm) from La to Lu were 0.028, 0.018, 0.006, 0.026, 0.006, 0.010, 0.017, 0.006, 0.016, 0.010, 0.016, 0.004, 0.023, and 0.012, respectively. The validity of the present method was confirmed by determining REEs in river water-certified reference materials, namely, SLRS-3 and SLRS-4.
Vertically-Ordered Mesoporous Silica Films for Electrochemical Detection of Hg(II) Ion in Pharmaceuticals and Soil Samples
Authors: Zhang Mengqi , Zou Yanqi , Zhou Xiaoyu , Yan Fei , Ding Zhanling
Published: June 2022

Rapid and simple determination of mercury ion (Hg2+) in pharmaceuticals and soil samples is vital for human health and the environmental monitoring. Vertically-ordered mesoporous silica films (VMSF) supported by the indium tin oxide (ITO) electrode surface were prepared by electrochemically assisted self-assembly method and utilized for electrochemical detection of Hg2+. Owing to the negatively charged channel walls and ultrasmall pore diameter, VMSF displays obvious cationic selectivity and has highly electrostatic interaction for Hg2+, giving rise to the strong electrochemical signals. By recording the anodic stripping signals of adsorbed Hg2+ using differential pulse voltammetry, quantitative detection of Hg2+ was achieved with a wide linear range (0.2 μM–20 μM) and a low limit of detection (3 nM). Furthermore, considering the anti-fouling and anti-interference capacity of VMSF, the proposed VMSF/ITO sensor has been successfully applied to detect Hg2+ in pharmaceuticals and soil samples without tedious pretreatment processes of samples.
Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet
Authors: Chen Zhe , Yang Bin , Wang Zhen , Rong Xianglu , Zhu Qing , Guo Jiao
Published: June 2022

Hypertension is frequently comorbid with the disorders of glucose and lipid metabolism. The increased intakes of fructose and salt contribute to the development of hypertension and related metabolic disorders, which are closely associated with gut dysbiosis. Fufang-Zhenzhu-Tiaozhi capsule (FTZ), a traditional Chinese patent medicine commonly used in clinical practice, has recently emerged as a promising drug candidate for metabolic diseases. In this study, FTZ treatment is identified as attenuating blood pressure increase and improving the metabolism of lipid and uric acid in high-fructose and high-salt (HFS) diet-fed rats. FTZ also substantially alleviated renal fibrosis and the mRNA expression of inflammation cytokines, NADPH oxidases, and the renin–angiotensin system in the renal cortex. 16S rRNA sequencing of fecal samples revealed that FTZ restored HFS-induced gut dysbiosis, seen as increased intestinal microbial richness and diversity. Furthermore, fecal microbiota transplantation also achieved similar therapeutic effects and alterations in gut microbiota profile induced by FTZ. Taken together, this study highlights the efficacy of FTZ in attenuating HFS-induced hypertension and related metabolic disorders and renal injury. The antihypertensive effect is associated with the modulation of gut microbiota.
Identification of Key Non-coding RNAs and Transcription Factors in Calcific Aortic Valve Disease
Authors: Guo Shuai , Zhang Erli , Zhang Bin , Liu Qingrong , Meng Zhen , Li Ziang , Wang Can , Gong Zhaoting , Wu Yongjian
Published: June 2022

Background

Calcific aortic valve disease (CAVD) is one of the most frequently occurring valvular heart diseases among the aging population. Currently, there is no known pharmacological treatment available to delay or reverse CAVD progression. The regulation of gene expression could contribute to the initiation, progression, and treatment of CAVD. Non-coding RNAs (ncRNAs) and transcription factors play essential regulatory roles in gene expression in CAVD; thus, further research is urgently needed.

Materials and Methods

The gene-expression profiles of GSE51472 and GSE12644 were obtained from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified in each dataset. A protein-protein-interaction (PPI) network of DEGs was then constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins database, and functional modules were analyzed with ClusterOne plugin in Cytoscape. Furthermore, Gene Ontology-functional annotation and Kyoto Encyclopedia of Genes and Genomes-pathway analysis were conducted for each functional module. Most crucially, ncRNAs and transcription factors acting on each functional module were separately identified using the RNAInter and TRRUST databases. The expression of predicted transcription factors and key genes was validated using GSE51472 and GSE12644. Furthermore, quantitative real-time PCR (qRT-PCR) experiments were performed to validate the differential expression of most promising candidates in human CAVD and control samples.

Results

Among 552 DEGs, 383 were upregulated and 169 were downregulated. In the PPI network, 15 functional modules involving 182 genes and proteins were identified. After hypergeometric testing, 45 ncRNAs and 33 transcription factors were obtained. Among the predicted transcription factors, CIITA, HIF1A, JUN, POU2F2, and STAT6 were differentially expressed in both the training and validation sets. In addition, we found that key genes, namely, CD2, CD86, CXCL8, FCGR3B, GZMB, ITGB2, LY86, MMP9, PPBP, and TYROBP were also differentially expressed in both the training and validation sets. Among the most promising candidates, differential expressions of ETS1, JUN, NFKB1, RELA, SP1, STAT1, ANCR, and LOC101927497 were identified via qRT-PCR experiments.

Conclusion

In this study, we identified functional modules with ncRNAs and transcription factors involved in CAVD pathogenesis. The current results suggest candidate molecules for further research on CAVD.
Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models
Authors: Zhang Xin-Yu , Yang Ke-Lu , Li Yang , Zhao Yang , Jiang Ke-Wei , Wang Quan , Liu Xiao-Nan
Published: June 2022

Introduction

Chemotherapy has significantly improved cancer survival rates at the cost of irreversible and frequent cardiovascular toxicity. As the main dose-dependent adverse effect, cardiotoxic effects not only limit the usage of chemotherapeutic agents, but also cause the high risk of severe poor prognoses for cancer survivors. Therefore, it is of great significance to seek more effective cardioprotective strategies. Some nutrients have been reported to diminish cardiac oxidative damage associated with chemotherapy. However, the currently available evidence is unclear, which requires a rigorous summary. As such, we conducted a systematic review of all available evidence and demonstrated whether nutrients derived from food could prevent cardiotoxicity caused by chemotherapy.

Methods

We searched Medline (via PubMed), Embase and the Cochrane Library from inception to Nov 9, 2021 to identify studies reporting dietary nutrients against cancer chemotherapy-related cardiotoxicity. We performed descriptive summaries on the included studies, and used forest plots to demonstrate the effects of various dietary nutrients.

Results

Fifty-seven eligible studies were identified, involving 53 animal studies carried on rats or mice and four human studies in cancer patients. Seven types of dietary nutrients were recognized including polyphenols (mainly extracted from grapes, grape seeds, and tea), allicin (mainly extracted form garlic), lycopene (mainly extracted from tomatoes), polyunsaturated fatty acids, amino acids (mainly referring to glutamine), coenzyme Q10, and trace elements (mainly referring to zinc and selenium). Dietary nutrients ameliorated left ventricular dysfunctions and myocardial oxidative stress at varying degrees, which were caused by chemotherapy. The overall risk of bias of included studies was at moderate to high risk.

Conclusion

The results indicated that dietary nutrients might be a potential strategy to protect cardiovascular system exposed to the chemotherapeutic agents, but more human studies are urged in this field.

Systematic Review Registration:https://inplasy.com/inplasy-2022-3-0015/.