bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of the Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review
Authors: Ambrosini Yoko , Borcherding Dana , Kanthasamy Anumantha , Kim Hyun Jung , Jergens Albert , Allenspach Karin , Mochel Jonathan
Published: February 2019

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo systems for therapeutic development and investigating disease pathophysiology. These animal models should have direct biological and translational relevance to the underlying disease they are supposed to mimic. Aging dogs naturally develop a cognitive decline in many aspects including learning and memory, but also exhibit human-like individual variability in the aging process. Neurodegenerative processes that can be observed in both human and canine brains include the progressive accumulation of β-amyloid (Aβ) found as diffuse plaques in the prefrontal cortex, including the gyrus proreus, the hippocampus, and in the cerebral vasculature. A growing body of epidemiological data shows that human patients with neurodegenerative diseases have concurrent intestinal lesions, and histopathological changes in the gastrointestinal (GI) tract occurs decades that evolve before neurodegenerative changes. Gut microbiome alterations also have been observed in many neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases, and inflammatory CNS diseases. Interestingly, only recently has the dog gut microbiome been recognized to more closely resemble in composition and in functional overlap with the human gut microbiome as compared to rodent models. This article aims to review the physiology of the gut-brain axis (GBA), and its involvement with neurodegenerative diseases in dogs and humans. Additionally, we outline the advantages and disadvantages of traditional in vitro and in vivo models and discuss future research directions investigating major human neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases using dogs.
Diagnostic Accuracy and Feasibility of Point-Of-Care Glycosylated Hemoglobin Estimation in Field Conditions in India
Authors: Khadanga Sagar , Pakhare Abhijit , Joshi Rajnish
Published: February 2019

Background: Measurement of glycosylated hemoglobin (HbA1c) levels is standard of care in assessment of glycemic control among diabetes mellitus patients. Traditional high performance liquid chromatography (HPLC) based tests are expensive, need specialized equipment, and have a longer turn-around-time. Point-of-care tests to estimate HbA1c levels are now commercially available but with only limited studies from developed nations. We performed this study to understand diagnostic accuracy of two commercially available HbA1c point-of-care test. Methods: The study was conducted in an urban and a rural outpatient clinic in central India. We compared HbA1c estimated from two index tests (Hemocue Hb501, Sweden; SD Biosensor, South Korea) from capillary blood samples and compared it with HPLC, as a reference standard in an independent and a blinded manner. We estimated diagnostic accuracy of the index tests as compared to the reference standard. Results: The area under Reciever Operating Curve (ROC) for SDBiosensor device was 0.935 (95% CI = 0.886–0.983), and for HemocueHb501 device was 0.938 (95% CI = 0.893–0.984). A SDBiosensor device HbA1c value of above 7.0% = 53 mmol/mol (positive test) correctly predicted poor glycemic control 92% times (vs. 81.58% for HemocueHb501divice). A HemocueHb501device HbA1c value of less than 7.0% = 53 mmol/mol (negative test) correctly predicted optimal glycemic control 91% times (vs. 85% by SDBiosensor device). There were 4, and 11 device failures, and 14 and 12 test failures with SDBiosensor device and HemocueHb501 device respectively. Ambient air temperatures were no different for the test failure rates as compared to the test success events. Conclusion: Commercially available point-of-care tests evaluated in this study are comparable and an acceptable alternative to HPLC based measurements for assessment of glycemic control. Tests and device failure rates of both the index tests were similar.
Overcoming Deterrent Metabolites by Gaining Essential Nutrients: A Lichen/Snail Case Study
Authors: Gadea Alice , Charrier Maryvonne , Fanuel Mathieu , Clerc Philippe , Daugan Corentin , Sauvager Aurélie , Rogniaux Hélène , Boustie Joël , Le Lamer Anne-Cécile , Le devehat Françoise
Published: February 2019

Lichen secondary metabolites are generally considered as repellent compounds for lichen feeders. Nevertheless, if the only food available consists in lichens rich in secondary metabolites, lichenophages such as Notodiscus hookeri, a gastropod native from the Possession Island, seem able to implement strategies to overcome the toxicity of these metabolites. Thus, the balance between phagostimulant nutrients and deterrent metabolites appears to play a key role in their feeding preferences. To further understand lichen-gastropod interactions, we studied the feeding behavior of Notodiscus hookeri fed exclusively with Usnea taylori, a lichen rich in usnic acid and arabitol. Snail feeding choice experiments with intact lichens vs acetone-rinsed lichens were carried out to study the influence of secondary metabolites. Simultaneously, usnic acid and arabitol were quantified and localized within the lichen thallus using HPLC-DAD-MS and in situ imaging by mass spectrometry to assess whether their spatial distribution induce preferential snail grazing. Then, no-choice feeding experiments were devised using usnic acid and arabitol embedded in artificial diet, separately or together.  This case study demonstrated that the nutritional activity of N. hookerii was governed by the chemical quality of the food and primarily by nutrient availability (arabitol), despite the presence of deterrent metabolites (usnic acid).
A Head and Neck Squamous Cell Carcinoma Model to Study and Target HPV Replication and Transcription
Authors: Evans Michael R. , Fontan Christian T. , James Claire D. , Wang Xu , Morgan Iain M. , Bristol Molly L.
Published: February 2019

The incidence of human papillomavirus-related head and neck squamous cell carcinoma (HPV+HNSCC) has reached epidemic levels in the last decade. While prophylactic vaccines will prevent future HPV infections, there are currently no HPV-specific antiviral drugs to treat current HPV infections or HPV+HNSCC. HPV replication and transcription are promising targets for anti-HPV therapeutics, as modulation of these processes can alter expression levels of HPV E6 and E7, which are required for maintenance of the transformed phenotype. This is a particularly attractive target in in HPV+HNSCC where the majority of tumors have episomal genomes replicating in an E1-E2 dependent manner. Here, we describe a model system to study HPV16 E1-E2 mediated DNA replication and HPV16 E2-mediated transcriptional activation and repression in multiple HNSCC cell lines. Our results demonstrate that low levels of IFIT1 are required for HPV16 replication in HNSCC cell lines and HPV16 E1 interacts with IFIT1. Restoration of IFIT1 expression in HNSCC cell lines partially inhibits HPV16 E1-E2 mediated replication. This system can be used to study replication and transcription by HPV16 E1 and E2 in HNSCC as well as be utilized to screen potential anti-HPV therapeutics that target HPV16 replication and transcription.
A Framework for Improving the Interpersonal Relationship of the Elderly with Mild Cognitive Impairment by Using Speaker Recognition and Social Network Platforms
Authors: Tan Tan-Hsu , Jean Fu-Rong , Lin Chia-Jung , Liu Tsung-Yu , Huang Yung-Fa
Published: February 2019

This study aims to develop an elderly care system for improving the interpersonal relationship of the elderly with mild cognitive impairment (MCI) by employing the speaker recognition technique and association functionality of social network platforms. Firstly, the speaker recognition units based on the Gaussian Mixture Model (GMM) and Gaussian Mixture Model-Universal Background Model (GMM-UBM) are implemented to identify the visitor via individual input utterance. After the visitor is identified, the proposed system will be linked to the private database and social network platforms to extract the associated message of two parties. Experimental results indicate that the speaker recognition unit based on GMM-UBM achieves the best performance. Finally, five elderly persons are invited to measure the usability of the proposed system. A questionnaire is used to survey the five elderly persons, and the result indicates that the proposed system is highly potentially applicable in improving the interpersonal relationship of the elderly with MCI.
Mental Health Issues in Madhya Pradesh: Insights from National Mental Health Survey of India 2016.
Authors: Kokane Arun , Pakhare Abhijit , Gururaj Gopalkrishna , Varghese Mathew , Benegal Vivek , Rao Girish , B A Aravind , Shukla Mukesh , Mitra Arun , Yadav Kriti , Chatterji Rajni , Ray Sukanya , Ranjan Akash
Published: February 2019

Background: India has one-fifth of the world's population and the number of people suffering from mental illness is assumed to be huge considering the contribution of mental disorders to the overall burden of the disease being 13.9 %. Objectives of Study: To estimate prevalence and patterns of mental illnesses to assess the current mental health services and systems in the Madhya Pradesh. Material and Methods: Multi-stage, stratified, random cluster sampling technique, with random selection based on probability proportionate to size at each stage. A total of 3240 individuals aged 18 years and above were interviewed. Both quantitative and qualitative methods were employed. A set of 10 instruments including Mini International Neuro-psychiatric Interview were utilized. Results: The overall weighted prevalence for any mental illness was 16.7% lifetime and 13.9% current. Treatment-gap for all mental health problems is as high as 91% in the state along with huge socioeconomic impact of mental illness. Conclusions: This huge burden of mental, behavioural and substance use disorders, in Madhya Pradesh, calls for immediate attention of political leaders, policy makers, health professionals, opinion-makers and society at large. It is hoped that the data from the study will inform mental health policy and legislation and help shape mental health care delivery systems in the country.
Molecular Docking Studies of Some Novel Fluoroquinolone Derivatives
Authors: Pintilie Lucia , Stefaniu Amalia
Published: February 2019

An important parameter in the development of a new drug is the drug's affinity to the identified target (protein/enzyme). Predicting the ligand binding to the target (protein/enzyme) by molecular simulation would allow the synthesis to be restricted to the most promising compounds.A restricted hybrid HF-DFT calculation was performed in order to obtain the most stable conformer of each ligand and a series of DFT calculations using the B3LYP levels with 6-31G* basis set has been conducted. The docking studies of the quinolone compounds will be performed with the CLC Drug Discovery Workbench to identify and visualize the ligand-receptor interaction mode.
Means as Improper Integrals
Authors: Gray John E. , Vogt Andrew
Published: February 2019

The aim of this work is to study generalizations of the notion of mean. Kolmogorov proposed a generalization based on an improper integral with a decay rate for the tail probabilities. This weak or Kolmogorov mean relates to the Weak Law of Large Numbers in the same way that the ordinary mean relates to the Strong Law. We propose a further generalization, also based on an improper integral, called the doubly weak mean, applicable to heavy-tailed distributions such as the Cauchy distribution and the other symmetric stable distributions, We also consider generalizations arising from Abel-Feynman type mollifiers that damp the behavior at infinity and alternative formulations of the mean in terms of the cumulative distribution and the characteristic function.
Site-Specific Treatment Responses in On-Farm Precision Experimentation
Authors: Trevisan Rodrigo Gonçalves , Bullock David S. , Martin Nicolas Federico
Published: February 2019

There is a large body of research on determining the impact of field variability of soil on crop yields. In contrast, site-specific information about crop responses to agronomic treatments is less frequent. On-Farm Precision Experimentation (OFPE) brings important information to understand the spatial variation of crop response to agronomic practices and thus to improve agronomic decisions. The objective of this work was to investigate the spatial variability of corn yield responses to nitrogen and seed rates using OFPE in four fields in the US Midwest. Geographically weighted regression was applied to generate local regression coefficients, which were used to delineate response zones in each field. The results showed the existence of great potential to adjust the rates of these inputs according to the response of each zone identified by the proposed method. The results of this study can be applied to reevaluate expectations on variable rate prescriptions guided largely by soil and variability.
Toward Optimality of Proper Generalised Decomposition Bases
Authors: Alameddin Shadi , Fau Amélie , Néron David , Ladevèze Pierre , Nackenhorst Udo
Published: February 2019

The solution of structural problems with nonlinear material behaviour in a model order reduction framework is investigated in this paper. In such a framework, greedy algorithms or adaptive strategies are interesting as they adjust the reduced order basis (ROB) to the problem of interest. However, these greedy strategies may lead to an excessive increase in the size of the reduced basis, i.e. the solution is no more represented in its optimal low-dimensional expansion. Here, an optimised strategy is proposed to maintain, at each step of the greedy algorithm, the lowest dimension of the PGD basis using a randomised SVD algorithm. Comparing to conventional approaches such as Gram-Schmidt orthonormalisation or deterministic SVD, it is shown to be very efficient both in terms of numerical cost and optimality of the reduced basis. Examples with different mesh densities are investigated to demonstrate the numerical efficiency of the presented method.
Scoping Review of the Person-Centered Literature in Adult Physical Rehabilitation
Authors: Jesus Tiago , Bright Felicity AS , Pinho Cátia S , Papadimitriou Christina , Kayes Nicola M , Cott Cheryl A
Published: February 2019

Objective: To map the literature pertaining to adult Person-Centered Rehabilitation (PCR).Data Sources:  Following our previously published scoping review protocol, data were identified through: three major databases, snowball searches and expert consultation.Study Selection: Two independent reviewers identified English-language papers which addressed adult physical rehabilitation and met one or more of the six pre-defined inclusion categories for PCR content. Data Extraction: Two independent reviewers extracted key characteristics of included papers (e.g. aims, methods, participants). Quantitative methods (descriptive statistics, regression analysis) and qualitative content analyses were used to synthesize the results.  Data synthesis: Of 5084 unique records initially screened, 145 papers were included: 111 empirical, including 11 systematic reviews. Empirical papers had data from 13498 clients and 3849 providers, in total. Yearly publications grew exponentially from 2000 to 2017 (r²= 0.65; p<0.01). Publications were unevenly distributed by countries (e.g. United States’ publications per population size was 45 times lower than New Zealand’s). Most papers focused in more than one profession, setting-type or health conditions, respectively 57.2%, 66.2%, and 60.7%. Finally, more than half of the empirical papers (53.2%) studied implementation of PCR approaches, including its effect. Conclusion: This scoping review synthesizes key characteristics and publication trends in the PCR literature, which is mainly empirical and growing exponentially over time. Stakeholders can use the identified trends, gaps, and literature map to guide further PCR research, and both clinical and organizational practices. The high prevalence of papers focused on multiple professions, settings-type, or health conditions reinforces the need for developing a transdisciplinary, trans-service model of PCR, which will be derived from a thematic analysis of this body of literature.
Alternative Process Routes to Manufacture Porous Ceramics – Opportunities and Challenges
Authors: Scheithauer Uwe , Kerber Florian , Füssel Alexander , Holtzhausen Stefan , Beckert Wieland , Schwarzer Eric , Weingarten Steven , Michaelis Alexander
Published: February 2019

Porous ceramics can be realized by different methods and are used for manifold applications, like cross-flow-membranes or wall-flow-filters, porous burners, solar receivers, structural design elements or catalytic supports. Within this paper three different alternative process routes are presented, which can be used to manufacture porous ceramic components with different properties or even graded porosity. The first process route bases on additive manufacturing (AM) of macro porous ceramic components, the second on AM of a polymeric template, which is used to manufacture porous ceramic components via replica technique. Finally, the third process route bases on an AM technology, which allows the manufacturing of multi-material or multi-property ceramic components, like components with dense and porous volumes in one complex shaped component.
Integrative System Biology Analyses Identify Seven Micrornas to Predict Heart Failure
Authors: Charrier Henri , Cuvelliez Marie , Dubois-Deruy Emilie , Mulder Paul , Richard Vincent , Bauters Christophe , Pinet Florence
Published: February 2019

Heart failure (HF) has several etiologies including myocardial infarction (MI) and left ventricular remodeling (LVR), but its progression remains difficult to predict in clinical practice. Systems biology analyses of LVR after MI predict molecular insights of this event such as modulation of microRNA (miRNA) that could be used as a signature of HF progression. To define a miRNA signature of LVR after MI, we use 2 systems biology approaches integrating either proteomic data generated from LV of post-MI rat induced by left coronary artery ligation or multi-omics data (proteins and non-coding RNAs) generated from plasma of post-MI patients from the REVE-2 study. The first approach predicts 13 miRNAs and 3 of these miRNAs were validated to be associated with LVR in vivo: miR-21-5p, miR-23a-3p and miR-222-3p. The second approach predicts 24 miRNAs among 1310 molecules and 6 of these miRNAs were selected to be associated with LVR in silico: miR-17-5p, miR-21-5p, miR-26b-5p, miR-222-3p, miR-335-5p and miR-375. We identified a signature of 7 microRNAs associated with LVR after MI that support the interest of integrative systems biology analyses to define a miRNA signature of HF progression.
Optimization of the COD Removal Efficiency for a Static Granular Bed Reactor Treating Poultry Slaughterhouse Wastewater
Authors: Rinquest Zainab , Basitere Moses , Mewa-Ngongang Maxwell , Ntwampe Seteno Karabo Obed , Njoya Mahomet
Published: February 2019

In this study, the efficiency of an anaerobic treatment system for wastewater from a South African poultry slaughterhouse was evaluated using a lab-scale static granular bed reactor (SGBR). The down-flow SGBR (2 L) was operated continuously for 138 days under mesophilic conditions (35-37 ˚C), at hydraulic retention times (HRTs) ranging from 24 to 96 h and average organic loading rates (OLRs) of 0.78 to 5.74 g COD/L.day. The SGBR achieved an average chemical oxygen demand (COD) removal efficiency of 80% and the maximum COD removal achieved was 95%, at an HRT of 24 h and average OLR of 5.74 g COD/L.day. The optimization of the SGBR, with regard to a suitable HRT and OLR, was determined using response surface methodology (RSM). The optimal SGBR performance with regard to the maximum COD removal efficiency was predicted for an OLR of 12.49 g COD/L.day and a HRT of 24 h, resulting in a 95.5% COD removal efficiency. The model R2 of 0.9638 indicated that the model is a good fit and is suitable to predict the COD removal efficiency for the SGBR.
DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple Cancers
Authors: Peterson Leif , Kovyrshina Tatiana
Published: February 2019

Removal of the proliferation component of gene expression by PCNA adjustment has been addressed in numerous survival prediction studies for breast cancer and all cancers in the TCGA. These studies indicate that widespread co-regulation of proliferation upwardly biases survival prediction when gene selection is performed on a genome-wide basis. In addition, removal of the correlative effects of proliferation does not reduce the random bias associated with survival prediction using random gene selection. Since most cancers become addicted to DNA repair as a result of forced cellular replication, increased oxidation, and repair deficiencies from oncogenic loss or genetic polymorphisms, we pursued an investigation to remove the proliferation component of expression in DNA repair genes to determine survival prediction. This translational hypothesis-driven focus on DNA repair genes is directly amenable to finding new sets of DNA repair genes that could potentially be studied for inhibition therapy. Overall survival (OS) prediction was evaluated in 18 cancers by using normalized RNA-Seq data for 126 DNA repair genes with expression available in TCGA. Transformations for normality and adjustments for age at diagnosis, stage, and PCNA metagene expression were performed for all DNA repair genes. We also analyzed genomic event rates (GER) for somatic mutations, deletions, and amplification in driver genes and DNA repair genes. After performing empirical p-value testing with use of randomly selected gene sets, it was observed that OS could be predicted significantly by sets of DNA repair genes for 61% (11/18) of the cancers. Interestingly, PARP1 was not a significant predictor of survival for any of the 11 cancers. Results from cluster analysis of GERs indicates that the most opportunistic cancers for inhibition therapy may be AML, colorectal, and renal papillary, because of potentially less confounding due to lower GERs for mutations, deletions, and amplifications in DNA repair genes. However, the most opportunistic cancer for inhibition therapy is likely to be AML, since it showed the lowest GERs for mutations, deletions, and amplifications in DNA repair genes. In conclusion, our hypothesis-driven focus to target DNA repair gene expression adjusted for the PCNA metagene as a means of predicting OS in various cancers resulted in statistically significant sets of genes.
Localized Learning of Downscaled Soil Moisture
Authors: Lewis Michael , Fisher Andmorgan , Smith Clint , Qu John , Houser Paul
Published: February 2019

If given the correct remotely sensed information, machine learning can accurately describe soil moisture conditions in a heterogeneous region at the large scale based on soil moisture readings at the small scale through rule transference across scale. This paper reviews an approach to increase soil moisture resolution over a sample region over Australia using the Soil Moisture Active Passive (SMAP) sensor and Landsat 8 only and a validation experiment using Sentinal-2 and the Advanced Microwave Scanning Radiometer (AMSR-E) over Nevada. This approach uses an inductive localized approach, replacing the need to obtain a deterministic model in favor of a learning model. This model is adaptable to heterogeneous conditions within a single scene unlike traditional polynomial fitting models and has fixed variables unlike most learning models. For the purposes of this analysis, the SMAP 36 km soil moisture product is considered fully valid and accurate. Landsat bands coinciding in collection date with a SMAP capture are down sampled to match the resolution of the SMAP product. A series of indices describing the Soil-Vegetation-Atmosphere Triangle (SVAT) relationship are then produced, including two novel variables, using the down sampled Landsat bands. These indices are then related to the local coincident SMAP values to identify a series of rules or trees to identify the local rules defining the relationship between soil moisture and the indices. The defined rules are then applied to the Landsat image in the native Landsat resolution to determine local soil moisture. Ground truth comparison is done via a series of grids using point soil moisture samples and air-borne L-band Multibeam Radiometer (PLMR) observations done under the SMAPEx-5 campaign. This paper uses a random forest due to its highly accurate learning against local ground truth data yet easily understandable rules. The predictive power of the inferred learning soil moisture algorithm did well with a mean absolute error of 0.054 over an airborne L-band retrieved surface over the same region.
Spatiotemporal Heterogeneity in the Distribution of Chikungunya and Zika Virus Case Incidences and Risk Factors during their Epidemics in Barranquilla, Colombia, between 2014 and 2016: An Ecological Study.
Authors: McHale Thomas C , Romero-Vivas Claudia M , Fronterre Claudio , Arango-Padilla Pedro , Falconar Andrew K , Waterlow Naomi R , Nix Chad , Cano Jorge
Published: February 2019

Chikungunya virus (CHIKV) and Zika virus (ZIKV) have recently emerged as global infections with consequential disability adjusted life years (DALYs) and economic burden. This study aimed to explore the spatiotemporal heterogeneity in the occurrence of CHIKV and ZIKV outbreaks throughout Barranquilla, Colombia during 2014 and 2016 and explored the potential for clustering. Incidence data were fitted using multiple Bayesian Poisson models based on a suite of explanatory variables as potential risk factors and multiple options for random effects. A best fit model was used to analyse the case incidence risk for both epidemics to identify any risk factors during their epidemics. Neighbourhoods in the northern region of Barranquilla were hotspots for the outbreaks of both CHIKV and ZIKV. Additional hotspots occurred in the south-western and central regions of the CHIKV and ZIKV outbreaks, respectively. Multivariate conditional autoregressive models strongly identified higher socioeconomic strata (SES) and residing in detached houses as risk factors for ZIKV case incidences. These novel findings challenge the belief that these infections are driven by social vulnerability and merits further study both in Barranquilla and throughout the tropical and subtropical regions of the world.
A Complete Assessment of Dopamine Receptor-Ligand Interactions through Computational Methods
Authors: Bueschbell Beatriz , Barreto Carlos A.V. , Preto Antonio J. , Schiedel Anke  C. , Moreira Irina S.
Published: February 2019

Background: Selectively targeting dopamine receptors has been a persistent challenge in the last years for the development of new treatments to combat the large variety of diseases evolving these receptors. Although, several drugs have been successfully brought to market, the subtype-specific binding mode on a molecular basis has not been fully elucidated. Methods: Homology modeling and molecular dynamics were applied to construct robust conformational models of all dopamine receptor subtypes (D1-like and D2-like receptors). Fifteen structurally diverse ligands were docked to these models. Contacts at the binding pocket were fully described in order to reveal new structural findings responsible for DR sub-type specificity. Results: We showed that the number of conformations for a receptor:ligand complex was associated to unspecific interactions > 2.5 Å and hydrophobic contacts, while the decoys binding energy was influenced by specific electrostatic interactions. Known residues such as 3.32Asp, the serine microdomain and the aromatic microdomain were found interacting in a variety of modes (HB, SB, π-stacking). Purposed TM2-TM3-TM7 microdomain was found to form a hydrophobic network involving Orthosteric Binding Pocket (OBP) and Secondary Binding Pocket (SBP). T-stacking interactions revealed as especially relevant for some large ligands such as apomorphine, risperidone or aripiprazole. Conclusions: This in silico approach was successful in showing known receptor-ligand interactions as well as in determining unique combinations of interactions, key for the design of more specific ligands.
BAHAN AJAR SAINS ANAK USIA DINI BERBASIS KEARIFAN LOKAL DAN NILAI KEISLAMAN
Authors: Diana Diana , Setiadi Anandita Eka
Published: February 2019

This research aims to develop learning materials at science based on local wisdom and islamic values that can be used at schools. This research conducted with research and development 4-D Model. There are four stages which are define, design, develop, and dessiminate. Data were collected through observation, interview, validation sheets and response sheets for teachers and students. Product learning materials tested limited trials at ANNUR kindergarten in Pontianak. The validity of the results achieved very valid. The results of validation learning materials achieved very well with score 81%. The results of a response teacher and students achieved strong category with score 76%. The conclusion about this research learning materials at science based on local wisdom and islamic values worthy to use in the learning process at schools.
Keywords: Learning material, Early childhood
Penelitian ini bertujuan untuk menghasilkan bahan ajar sains anak usia dini berbasis kearifan lokal dan nilai keislaman yang layak digunakan dalam proses pembelajaran di sekolah. Penelitian ini menggunakan metode pengembangan Four D (Model 4D). Terdapat empat tahapan dimulai dari define, design, develop, dan dessiminate. Pengambilan data menggunakan lembar observasi, lembar wawancara, lembar validasi dan angket respon untuk guru dan siswa. Analisa data menggunakan metode deskriptif. Produk bahan ajar melalui uji coba terbatas di TK ANNUR di Kota Pontianak. Hasil penilaian bahan ajar oleh validator sebesar 81% dengan kriteria sangat valid. Respon siswa dan guru terhadap bahan ajar sebesar 76% dengan kriteria kuat. Disimpukan bahwa bahan ajar berbasis kearifan lokal dan nilai keislaman layak digunakan dalam proses pembelajaran.
Kata Kunci: Bahan ajar, Anak usia dini
MODEL ALAT BANTU LATIHAN (HAND PADDLE) UNTUK PERENANG USIA DINI
Authors: Marani Ika Novitaria , Miftakhudin Heru
Published: February 2019

This study aims to develop a model of exercise aids (hand paddle) as a training medium to train finger density in early swimmers. The research method used is the Sugiyonoâ€™s model of research and development method. Hand paddle modification was developed through a small-scale trial of 29 early swimmers from 3 swimming associations in East Jakarta. Small-scale trials were conducted using the pre-posttest design experiment with 6 training sessions using paddle modification. The results of the research and product development showed that (1) the media of exercise aids (hand paddle) significantly increased the density of the fingers in early childhood (2) the validity of exercise aid media indicated by the results of 87% swimming expert validity with the category very feasible and the validity of 75% biomechanics experts with appropriate categories, (3) The effectiveness of hand paddle media indicated by the results of the pretest and posttest, obtained tcount = 6.71> t table - 2.06, with sig (2 tailed) and degrees of freedom) .05
Keyword: Hand paddle, swimming, early age
Penelitian ini memiliki tujuan untuk mengembangkan model alat bantu latihan (hand paddle) sebagai media latihan melatih kerapatan jari tangan pada perenang usia dini. Metode penelitian yang digunakan adalah metode penelitian dan pengembangan (R & D) model Sugiyono. Modifikasi hand paddle dikembangkan melalui uji coba skala kecil terhadap 29 perenang usia dini dari 3 perkumpulan renang di Jakarta Timur. Uji coba skala kecil dilakukan dengan menggunakan eksperimen pre-posttest design dengan 6 kali sesi latihan menggunakan paddle modifikasi. Hasil penelitian dan pengembangan produk yang dihasilkan menunjukkan bahwa (1) Media alat bantu latihan (hand paddle) signifikan meningkatkan kerapatan jari â€“ jari tangan pada anak usia dini (2) Kevalidan media alat bantu latihan yang ditunjukkan oleh hasil validitas ahli renang 87% dengan kategori sangat layak dan validitas ahli biomekanika 75% dengan kategori layak, (3) Keefektifan media alat bantu (hand paddle) yang ditunjukkan oleh hasil pretest dan posttest, diperoleh thitung = 6.71 > ttabel â€“ 2.06, dengan sig (2 tailed) dan derajat kebebasan 0.05.
Kata Kunci: Hand paddle, Latihan Renang, Usia Dini
PENGEMBANGAN KEMAMPUAN BERBICARA BAHASA INDONESIA ANAK UMUR 5-6 TAHUN MELALUI METODE BERCERITA DENGAN MEDIA TELEVISI BERGAMBAR
Authors: Alfin Jauharoti , Rosyidi Zudan , Abdillah Husni
Published: February 2019

This study was aimed to obtain a description of ability to speak Indonesian through story telling with pictorial television media in children 5-6 years. The method of the study used Weak Experimental with One-Shot-Case-Study design. The subjects of the study were 27 kindergarten children 5-6 years in Gresik City. Data were collected using observation and documentation and analyzed using descriptive and quantitative method. The results showed that their ability to speak Indonesian language has developed in high category (85%) after the treatment through story telling with pictorial television media.
Keywords: Speaking ability, Indonesian Language, children aged 5-6 years, pictorial television media
Penelitian ini bertujuan untuk memperoleh gambaran mengenai kemampuan berbicara Bahasa Indonesia anak umur 5-6 tahun yang dikembangkan melalui metode bercerita dengan media televisi bergambar. Metode penelitian yang digunakan adalah Weak Experimental dengan desain One-Shot-Case-Study. Subyek penelitian sebanyak 27 anak umur 5-6 tahun dari salah satu TK di Kota Gresik. Pengumpulan data dilakukan melalui observasi dan dokumentasi. Hasil pengumpulan data selanjutnya dianalisis secara deskriptif dan kuantitatif dengan menentukan nilai persentase dari masing-masing indikator perkembangan kemampuan berbicara Bahasa Indonesia anak. Hasil penelitian menunjukkan bahwa secara kesuluruhan kemampuan berbicara Bahasa Indonesia anak umur 5-6 tahun telah berkembang dalam kategori tinggi (85%) setelah perlakuan penggunaan metode bercerita dengan media televisi bergambar.
Kata kunci: Kemampuan berbicara, Bahasa Indonesia, anak umur 5-6 tahun, media televisi bergambar.
PENGEMBANGAN MEDIA SLIDING BOOK UNTUK PENGENALAN SAINS KEHIDUPAN (LIFE SCIENCE) KELAUTAN UNTUK ANAK USIA 6-7 TAHUN
Authors: Pramitasari Muktia , Yetti Elindra , Hapidin Hapidin
Published: February 2019

This study aims to develop sliding book as medium to introduction of marine life science in early childhood. The research method used is research & development with ADDIE model. The data collection technique used based on the result of expert vaidation and effectiveness test through quasi experiment with data analysis of paired t-test statistic. The study involved childhren age 6-7 years in Tangerang Selatan distric. The results of research and product development shows: 1) the sliding book medium design is feasible to introduce the marine life science, 2) the effectiveness of medium is shown by the result of pre-test & post-test of childhren obtain by the t-value, and sig. 2 tailed < 0.05, 3) the validity of mdium indicated by the test of life science material expert recommendation of this research is the effort to develop marine literacy media for early childhood, so it will be rich in marine insight, formed a strong mindset and marine spirit. 
Keywords: Early Chilhood, , Life science, Marine, Sliding Book
Penelitian ini bertujuan untuk mengembangkan media sliding book untuk pengenalan sains kehidupan kelautan untuk anak usia dini. Penelitian dilakukan dengan metode penelitian research & developmet/R&D. Data dikumpulkan melalui analisis kebutuhan (studi literatur, analisis komparatif, wawancara & observasi), angket untuk pakar,  pre test dan post test untuk anak. Analisa data kualitatif dilakukan berdasar hasil wawancara dan observasi sedangkan kuantitatif dengan uji t- berpasangan. Hasil penelitian menunjukkan bahwa perancangan media sliding book layak dan efektif untuk mengenalkan sains kehidupan kelautan. Rekomendasi penelitian ini yaitu upaya mengembangkan media literasi tentang kelautan untuk anak usia dini, sehingga kelak akan kaya akan wawasan kelautan, terbentuk pola pikir dan jiwa kelautan yang kuat.
Kata Kunci: Anak Usia Dini, Sains Kehidupan, Kelautan, Sliding Book
On the Names of First Philosophy in the Proem to Francisco Suárez’s Disputationes Metaphysicae
Authors: FELIPE MENDOZA José María
Published: February 2019

This study provides a thorough exegesis of the names of metaphysics according to the proem of the Disputationes metaphysicae by Francis Suarez. The key to its consideration lies in the simultaneous unity between this science and the names assigned to it mainly by Aristotle. Due to the scant attention devoted to this work, this study emphasizes that the epistemic unity of metaphysics is given beforehand –prior to the final consideration and determination of its proper object, which is the entity insofar real entity– by the complementarity of the different perspectives each name of metaphysics denotes.
Editorial
Authors: Peña Soto Claudio
Published: February 2019

Hoy en día vivimos en una aldea global y, por lo tanto, los retos para la universidad son mayores. Considero que el mayor reto de la universidad es contribuir significativamente a construir una sociedad basada en el conocimiento, que afronte con eficacia y equidad los grandes problemas del país, la región y el mundo.Es un hecho que nuestras sociedades contemporáneas dependen cada vez más del conocimiento y esto lo vivimos día a día; por ejemplo, para utilizar un celular tipo smartphone debemos tener un conocimiento previo e incluso desarrollar un nuevo conocimiento si queremos sacarle el mayor provecho al equipo. Lo mismo ocurre con nuevos conceptos que son ahora claves para la competitividad en los mercados internacionales, tales como calidad total, entrega a tiempo, automatización, producción flexible y productos hechos a la medida de las necesidades de cada usuario. Estos conceptos no pueden hacerse realidad de forma competitiva sin tecnologías sofisticadas, cuyo soporte fundamental es el conocimiento científico.Con el advenimiento de las biotecnologías y la próxima era genética del siglo XXI, esta tendencia se agudizará en el futuro; la capacidad de producir y usar conocimiento será considerada crecientemente como el recurso de mayor importancia de las naciones y el aspecto determinante de su productividad. Es ahí donde la universidad debe jugar un rol protagónico con el objetivo de aumentar la productividad sostenidamente, cerrar las brechas sociales, mantener altas tasas de crecimiento económico y ser competitivos a escala mundial.El compromiso que hoy en día la Carrera de Estomatología de la Universidad Científica del Sur tiene para construir una sociedad basada en el conocimiento se refleja en incluir la investigación formativa y las acciones de responsabilidad social universitaria en su currículum; así como la Revista Científica Odontológica, la cual está en un proceso de indización internacional. Somos conscientes de los retos que debemos afrontar en un corto y mediano plazo y que enfrentamos con optimismo, ya que confiamos en el motor más importante de toda organización: el capital humano.
Usos y limitaciones de la tomografía computarizada de haz cónico (TCHC) y la tomografía computarizada multidetector (TCMD) en cirugía de cabeza y cuello:
Authors: Mora Mendoza Jorge Iván
Published: February 2019

Desde su introducción en el campo médico en la década de los 70, la tomografía computarizada ha sido de granvalor diagnóstico en las diferentes zonas anatómicas corporales. Este avance fue estudiado y adaptado por la radiología oral y maxilofacial, desarrollando un equipo, el cual utiliza un haz cónico de rayos X, los cuales son captados por sensores que reconstruyen una imagen tridimensional que mejora su capacidad de visualización de las diferentes estructuras orofaciales, lo que evita la superposición de imágenes que se producían en los exámenes tradicionales 2D. La tomografía computarizada de haz cónico (TCHC) ha incrementado su uso en otros campos de la región de cabeza y cuello, principalmente en las áreas que involucran la reconstrucción de tejidos óseos o correcciones de anomalías congénitas o adquiridas; por su gran calidad de imagen, su baja dosis de radiacióncomparada con los equipos médicos tradicionalmente usados y su bajo costo. Debido a esto, y al no existir protocolos ni consensos definidos sobre los usos y limitaciones de esta tecnología, se realizó esta revisión teniendo en cuenta las diferentes aplicaciones de la TCHC en el área de la cirugía de cabeza y cuello.
Asimetría de cóndilos y ramas mandibulares en individuos desdentados parciales. Una revisión de la literatura
Authors: Quiroz Padilla Ana Maciel
Published: February 2019

Las imágenes radiográficas 2D, como la radiografía panorámica, han sido utilizadas a través de los años comoexámenes iniciales para la evaluación de la asimetría mandibular. El primero en realizar medidas sobre cóndilos y ramas mandibulares fue Habets, en 1988, y concluyó que la existencia de diferencias entre las alturas condilares podrían ser el inicio de trastornos temporomandibulares. En los últimos estudios revisados para el propósito de este trabajo, se han creado nuevas técnicas en 2D, pero además se ha desarrollado la tecnología de imágenes 3D, cuyo aporte a los datos cuantificables es fundamental para el tema estudiado. Revisando artículos publicados sobre las asimetrías mandibulares, identificando la frecuencia, las características imagenológicas y estableciendo las ventajas y limitaciones que se presentan en pacientes desdentados parciales mediante el diagnóstico de la asimetría mandibular en técnicas realizadas en imágenes 2D y 3D.
Havas-Lima o la inclusión del Perú en la red internacional de información del siglo XIX
Authors: Desbordes Vela Rhoda
Published: February 2019

Este estudio histórico del desarrollo de las agencias internacionales de noticias en América del Sur tiene en cuenta especialmente la instalación de las grandes agenciasinternacionales en el subcontinente en general y en el Perú en particular. Este punto de vista ataca de entrada una idea preconcebida en la historiografía «agenciera». Enefecto, la bibliografía existente destaca solo las sucursales de Buenos Aires y de Río de Janeiro, como los primeros y únicos focos de la presencia de la agencia francesa enSudamérica. No obstante, otros puntos, y en momentos distintos, también contribuyeron a este primer impulso y a la materialización de una pequeña red de sucursales de lasagencias mundiales. Uno de estos otros novedosos lugares de explotación es, evidentemente, la sucursal de Lima.
Cardiac arrest in orthopedic surgery – a case report
Authors: Burgdorff Anna-Maria , Flöther Lilit , Wohlrab David
Published: February 2019

Background: Unexpected cardiac arrest in patients during surgery is associated with high mortality. Reasons are often multifactorial and not exactly clear.
Case presentation: Therefore, this case report describes a patient, who developed reversible asystole during knee surgery under general anesthesia. All diagnostic cardiac examinations were unremarkable. After surgery the patient showed no further symptoms.
Conclusion: To prevent cardiac arrest due to non-cardiac reasons, patients with high risk for asystole caused by vasovagal reflex or pain need to be identified. Preoperative conditions like hypovolemia need to be improved and additional monitoring should be used. Further investigations to find the influence of non-cardiac disease and long-term medication are necessary.
Keywords: Cardiac arrest, bradycardia, asystole, total knee arthroplasty.
Structural Health Monitoring System of a Concrete Cable-Stayed Bridge
Authors: BILISZCZUK Jan , HAWRYSZKÓW Paweł , TEICHGRAEBER Marco
Published: February 2019

In this paper a system of the Rędziński bridge will be described. The Rędziński bridge is the biggest object along the A8 motorway around the city of Wrocław and the biggest concrete cable-stayed bridge in Poland. For the purposes of the bridge monitoring a system of 222 sensors was installed. Results from the first 5 years of work of the SHM will be presented below.
Effects of Staircase on the Seismic Behavior of RC Moment Frame Buildings
Authors: NOORIFARD Azadeh , TABESHPOUR Mohammad Reza
Published: February 2019

Staircase has a potential to change the seismic behavior of structures, but it is often neglected during design. In this research, effects of staircase in 5 groups including 27 models have been studied. Results show that staircase constructed with the use of RC slab, performs as a K-shaped bracing in longitudinal direction and as an inclined shear wall in transverse direction, so in both directions structural stiffness increases, period and lateral displacement of structure decrease, but staircase constructed by means of stringer beam only acts as a bracing in longitudinal direction. Stiffness caused by small span, inclined RC slabs and perimeter infill walls of staircase, based on the staircase location and the number of structural bays could change mode shape and lead to torsion. Along ladder running, staircase leads shear force and bending moment of columns adjacent to the landing to increase, while the internal forces of others to decrease. The majority of adverse effects of the staircases can be prevented by isolating the staircase from master structure. In this case, only the changes in geometry of the structure due to location and dimension of staircase and arrangement of infill walls should be studied.
Comprehensive Energy Diagnostics Carried Out In a Residential Building – A Case Study
Authors: BARTOSZ Dorota
Published: February 2019

The article presents the case study of the comprehensive diagnosis of an existing residential building with natural ventilation. The results of quick diagnostics of thermal insulation of the building, the heating system, ventilation, domestic hot water preparation and the quality of the environment in the rooms were presented. Based on the data obtained by measurements, the energy performance of the building was prepared using the building certification calculation method. The energy performance of the building was also prepared using the developed method of determining energy performance based on measurements.
Assessing the Value of Grazed Corn Residue for Crop and Cattle Producers
Authors: Redfearn Daren , Parsons Jay , Drewnoski Mary , Schmer Marty , Mitchell Rob , MacDonald James , Farney Jaymelynn , Smart Alexander
Published: February 2019

Core Ideas

Grazed corn residue is a cost‐efficient forage resource.

Current value of grazed corn residue is $95 M returned to the crop sector in NE, SD, KS, and ND.

Gross value for grazed corn residue is $191 M for the beef cattle sector in NE, SD, KS, and ND.

Opportunities exist to increase use of corn residue grazing.

Transportation costs and animal care arrangements are complicating factors.

Integrated crop–livestock systems have included grazing perennial grasses during the spring and summer and corn (Zea mays L.) residues during the winter. Our objectives were to identify opportunities for expanded corn residue use through grazing and provide an economic assessment for value‐added grazing. We estimated the economic value to the crop sector through grazing leased corn residue at over $95 million for Nebraska, South Dakota, Kansas, and North Dakota under current management. Additionally, gross economic value to the livestock sector in these states was estimated at greater than $191 million. Advantages for increased grazing use of corn residue include managing residue quantity in high‐yielding environments, providing a source of supplemental revenue, and expanding integrated crop–livestock systems using a simple, but cost‐efficient practice.