bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Seasonal Variations of Air Quality and AQI Status: Evidence from Chittagong, Bangladesh
Authors: Hoque Mir Md. Mozammal , Khan Md. Moshiuzzaman , Sarker Md. Eusuf , Hossain Md. Nuralam , Islam Md. Sirajul , Khan Md. Mehedi Hasan , Shil Manik , Sarker Md. Nazirul Islam
Published: September 2022

With the rate of fast urbanization, the devasting effects of air pollution are spreading across the globe. Due to its connection to people’s health, air quality should be given more importance than other environmental measures. Air pollution is considered a cause of many human diseases. Therefore, this study intends to investigate seasonal variation of air quality and “Air Quality Index (AQI)” in Chittagong city due to its volume, large population density, and importance as a commercial capital city of Bangladesh. Air pollution data on PM10, PM2.5, NO2 , NOx, SOx, CO, and O3 levels have been collected from TV station, Khulshi Continuous Air Monitoring Station (CAMS). Component-specific analyzers have been used to continuously measure trace gases where O3 is observed with a UV photometric analyzer. This study detect the highest peak (PM2.5= 93.5 µg/m3, PM10= 210 µg/m3) in January and the lowest concentrations (PM2.5= 14.6 µg/m3 and PM10= 26.9 µg/m3 ) during July and August. The highest average concentration has been recorded as the value of SO2= 12.8 ppb (monsoon season), NO2= 64.9 ppb (pre-monsoon), CO= 1.2 ppm (monsoon) and lowest SO2= 3.2 ppb (winter season), NO2= 24.4 ppb (monsoon), CO= 0.6 ppm (pre-monsoon) respectively. The AQI values (223.6), (109.5), (194.5), and (317.3) indicate that the air quality during the pre-monsoon, monsoon, post-monsoon, and winter season is very unhealthy, cautious, unhealthy, and extremely unhealthy, respectively.
Effects of Procainamide on CTLA-4 and CD28 Expression in Drug-Induced Lupus: A Research Protocol
Authors: Kim Rachel , Sheth Nishaad C.
Published: September 2022

Introduction: Lupus erythematosus is a chronic autoimmune disease affecting over 5 million individuals worldwide, characterized by overactivation of B and T lymphocytes. Of these, 10% of patients are diagnosed with drug- induced lupus (DIL), which is caused by high doses of medications such as procainamide, with 20% of procainamide users developing DIL. CTLA-4 and CD28 receptors on T-cell surfaces bind to B7 proteins on antigen-presenting cells, halting and promoting T-cell activation, respectively. Studies indicate that certain lupus symptoms are linked to abnormal CTLA-4/CD28 expression, resulting in overreactive CD4+ T-cells. However, the exact nature of the relationship between CTLA-4 and lupus remains nonunanimous. Other studies show that procainamide alters DNA methylation7, while altered CTLA-4 methylation has been tied to autoimmune disorders. Thus, we hypothesize that procainamide leads to reduced CTLA-4 expression and/or increased CD28 expression, causing DIL symptoms.
Methods: We propose an in vivo experiment involving time-matched mouse models. CITE-seq analyses would be run on isolated T-cells from the splenic samples to obtain transcriptome and epitope data and to examine the expression of CTLA-4, CD28, and other potential genes of interest. To corroborate CITE-seq results, the T-cells would undergo immunohistochemical staining with primary and fluorescent antibodies that bind to CTLA-4/CD28.
Expected Results: Results are expected to indicate decreased CTLA-4 gene and protein expression, or increased CD28 gene and protein expression on the surface of procainamide-treated T-cells.
Discussion: If our analyses prove successful, potential next steps involve using gene editing technologies to screen, pinpoint, and correct the molecular mechanisms implicated in procainamide-induced DIL. Further analysis may also implicate additional or other genes of interest involved in the etiology of the disease.
Conclusion: This study is expected to provide insight into the effect of procainamide on molecular mechanisms involved in DIL. Further applications may involve adjunct therapies aimed at mitigating or preventing the development of DIL symptoms.
Served space: new achievements and perspectives
Authors: Katkalov V. B. , Morozova M. L.
Published: September 2022

The number of works aimed at developing technologies for services in space has increased significantly over the past five years. In addition to such industrial giants as Orbital-ATK, Northrop Grumman, MDA, Maxar Technologies, startups are also entering the service market that develop and demonstrate practically operating technologies. Given this trend, it is expected that maintenance in space will become a hot topic over the next few years. The article discusses the designed and operating service spacecraft of foreign countries, the state and directions of their development. Brief characteristics and capabilities of service spacecraft are given. The directions of solving the main tasks for the design and manufacture of promising service spacecraft are outlined. Satellites MEV-1 and MEV-2, manufactured by Northrop Grumman, ELSA-d, manufactured by Astroscale and SSTL, and See also OSAM-1 by Maxar Technologies, which allows robotic refueling in space and demonstrates the possibility of constructing large structures in space without direct human involvement. The results of a study carried out using available Internet sources are summarized and presented in this material. The purpose of the article is to analyze the need, ways and methods of development of services, to assess the prospects of the technologies used.
سياسات المياه العالمية 2021 : الاستماع الى قادة المياه الوطنيين
Authors: Mostafa Ghareb Hader
Published: September 2022

 أحد أكبر المخاطر التي واجهتها الدول فيما يتعلق بقضايا المياه خلال عام 2021، كانت نتيجة للتغيرات المناخية والضغوط المرتبطة بها على إمدادات المياه.
 على الرغم من الجهود المبذولة لتأكيد أهمية المياه في إدارة جائحة كورونا والتعافي منها، لم يغير الوباء كثيرًا من أولويات قضايا المياه لدى الحكومات.
 سيتطلب تحسين نتائج المياه في العديد من البلدان، تحقيق التكامل في إدارة المياه، والارتقاء بالأولوية العامة لقضايا المياه لدى الحكومات.
 لا يزال هدف التنمية المستدامة الخاص بالمياه بعيد المنال بالنسبة للعديد من البلدان، وقد يكون تقديم الدعم في مجالي تعزيز الحوكمة والتمويل أكثر فائدة في هذا الشأن.
 المياه الجوفية مهمة لإمدادات المياه المستقبلية، غير أنها معرضة لخطر الاستخدام غير المستدام في العديد من المناطق حول العالم، وتحتاج إلى مزيد من الاهتمام فيما يتعلق بالتخطيط والإدارة.
HEAVY METALS CONTENT ASSESSMENT IN WILD HOP CONES FROM THE «KEDROVSKY» COAL MINING DUMP
Authors: I.N. Egorova , T.I. Grigorieva , O.A. Neverova
Published: September 2022

Abstract. Heavy metals content has been analyzed in plant raw materials of the wild hop (Humulus lupulus L.) cones the hemp family (Cannabaceae) representative growing on the waste dump "Yuzhny" coal mine "Kedrovsky". This perennial liana is found throughout the Kemerovo region-Kuzbass. It is a valuable medicinal plant material. It contains a rich biologically active compounds complex. Heavy metals content analysis in the studied embryozems samples showed that the maximum values are for Mn (54.438±15.900 mg/kg) and Fe (38.278±9.539 mg/kg), the minimum for Cu (0.218±0.016 mg/kg) and Cd (0.167±0.016 mg/kg). The study did not reveal their excess in comparison with the hygienic standards of maximum permissible concentration (approximate permissible concentration). It was experimentally found that wild hop cones accumulate to a greater extent two biophile elements - Cu and Zn. In addition, there are quite significant differences in the quantitative characteristics of the content of these elements in the seedlings of common hop and conjugated embryozems from the places of its growth. With a slight accumulation of these elements’ mobile forms in embryozems: Zn (1.481 ± 0.101 mg / kg), Cu (0.218 ± 0.016 mg / kg), in plant raw materials, the accumulation of these elements is a priority: Zn - 15.20 ± 0.153 mg / kg, Cu – 5.123±0.054 mg/kg. These elements also describe with the greatest biological mobility. For Cu and Zn, the coefficient of biological mobility (Bx) is maximal in the wild hop cones - 23.50 and 10.26 respectively. Obtained data analysis showed that there was no standardized heavy metals MPC excess in the raw material Humulus lupulus L. adopted for medicinal plant materials, which does not pose a danger to human life and health.
NON-EXPERIMENTAL SEARCH FOR MOLECULES WITH ANTITUMOR ACTIVITY AND MOLECULAR DOCKING IN THE SERIES OF PYRIDINECARBOXY ACID DERIVATIVES
Authors: O.N. Deryabina , M.Yu. Kudryavtsev , O.N. Tumutolova , E.V. Blinova , A.A. Epishkina , S.Ya. Skachilova , D.S. Blinov
Published: September 2022

Abstract. In the work, a pre-experimental screening of pyridinecarboxylic acid derivatives was performed by the PASS program, The work identified potential molecular targets for the implementation of the antitumor effect of a new domestic compound, an analogue of pyridine LHT-13-19. Using the "Autodock 4.2" software environment, flexible receptor-directed molecular biological docking was carried out in virtual reality, which makes it possible to most accurately predict the formation of a complex between a molecular structure and a biological target in real conditions of a specific biological system. For molecular docking, three-dimensional structures of the epidermal growth factor receptor (EGFR, PDB ID: 1M17, 4KN2) from the open electronic library Protein Data Bank (USA) were used. Molecules of compounds - pyridine derivatives LHT-13-19, LHT-16-19 and LHT-17-19 were synthesized in the Department of Chemistry, All-Union Research Center for Biological Active Compounds Safety (Russia). As a result of the experiments, it was found that all the studied molecules have inhibitory activity against proto-oncogenic kinases, however, in terms of the totality of predictive characteristics, as well as the likelihood of forming an antitumor effect, LHT-17-19, which was studied in docking studies, turned out to be the most promising compound. It was shown that LHT-17-19 has a high affinity for the epidermal growth factor kinase receptor EGFR-K, exhibits an affinity for the CSF1 receptor system, superior to that of all comparators - imatinib, erlotinib and pemetrexed. Also, in the process of docking approach and subsequent docking with the active site of tyrosine kinase EGFR-K and the human folate receptor FOLR2, an additional hydrogen bond is formed inside the LHT-17-19 molecule between the hydrogen proton of the amino group and the oxygen atom of the carbonyl group with atomic distances of 2.21 Å and 2 .49 Å, respectively.
DEVELOPMENT AND CURRENT ASPECTS OF HEALTHCARE DIGITALIZATION IN ARCHANGELSK REGION OF RUSSIA
Authors: R.V. Kubasov , M.I. Mytsuk , Y.A. Lenina , E.D. Kubasova , V.V. Lupachev
Published: September 2022

Abstract. Currently, the development and implementation of digital medicine is closely related to the use of IT technologies. They, in turn, provide Internet navigation of population in the healthcare system, disease prevention and healthy lifestyle organization and clinical telemedicine, as well as support for scientific clinical solutions. Over the last 5 years, the Arkhangelsk region has made a significant advance in the implementation of telemedicine technologies. The number of medical organizations that can carry out telemedicine consultations has increased many times. At the same time, more than 80 % of telemedicine studios are located on central district hospitals and outpatient clinics. The most frequently employed specialists for telemedicine consultations were physicians in the following areas: x-ray (14%), traumatology (9.5%), surgery (9%), neurosurgery (8.5%), hematology (8%), neurology (7.5%), cardiology (7%). A particular place in the telemedicine system in the Arkhangelsk region is taken by the Perinatal Center of the Arkhangelsk Regional Clinical Hospital, which was started in 2018. It is equipped with all the necessary medical and technological equipment. It organizes the work of auxiliary offices with the use of telemedicine technologies: obstetric external consulting room; neonatal remote consulting room. If necessary and in order to ensure emergency medical evacuation of patients from hard-to-reach areas, the obstetric remote consultation center is in constant cooperation with the regional center of the Disaster Medicine service, civil defense, emergency situations and disaster response units and medical organizations entrusted with the functions of providing emergency specialized (sanitary aviation) medical care.
THERAPEUTIC ISSUES OF GASTROINTESTINAL DISEASES AND REVIEW OF THE RANGE OF DRUGS USED FOR THE TREATMENT AND PREVENTION OF DISEASES OF THE DIGESTIVE TRACT
Authors: I.S. Avduev
Published: September 2022

Abstract. The article considers data on diseases of the digestive system, causes, relationship with gender, age, dynamics of changes in the overall incidence of the gastrointestinal tract in the Russian Federation according to Rosstat, and finally, the structure of the range of drugs prescribed for the treatment of these pathologies, including including chronic pancreatitis, as one of the most common diseases of the digestive tract, in a hospital setting. Diseases of the gastrointestinal tract is an urgent problem in modern clinical therapy, which is associated with an annual increase in the number of patients suffering from certain pathologies. The concept of "quality of life" and its features are given. According to the Russian Ministry of Health, calculated by the Federal State Statistics Service, the number of patients with general morbidity of the gastrointestinal tract in our country has increased from 2000 to 2018. An example of a survey of a number of patients diagnosed with gastroesophageal reflux disease is considered, during which it was revealed that heartburn, as a symptom of this disease, reduces the quality of life of patients, which is associated with a deterioration in work activity, sleep and wakefulness, quality of nutrition and satisfaction and quality of sexual life. Studies of the assortment structure showed the prevalence of imported drugs over domestic ones, in the used structure. Most drugs are imported from India, France and Germany, which account for about 55% of all drugs used. Nevertheless, the Russian market has a sufficient number of domestic drugs involved in the treatment and prevention of diseases of the digestive system. A list of drugs used in stationary conditions was compiled.
RESULTS OF THE APPLICATION OF THE COMBINED METHOD IN THE TREATMENT OF CHILDREN WITH PLANE-VALGUS DEFORMATION UNDER STATIONARY CONDITIONS
Authors: G.P. Kotelnikov , Y.V. Lartsev , O.D. Bagdulina , A.V. Shmelkov , N.E. Liholatov
Published: September 2022

Abstract. Patients (n = 66) were divided into 2 groups. In the main group, tendon-muscle plasty was performed in the form of transposition and tenodesis of the tendon of the anterior tibial muscle in the cleft of the navicular bone, and in the control, a combination of this type of tendon-muscle plasty and subtalar arthroeresis. In the period from 2016-2021, the ortho-paediatric department of Clinic of the Samara State Medical University carried out a comprehensive treatment of 66 children with plano-valgus deformity of the feet, which included surgical correction, immobilization of the limb in the postoperative period and rehabilitation treatment for all periods of postoperative observation. Our results indicate the need for an integrated approach in the treatment of flat-valgus deformity of the feet, which includes the formation of an anatomically correct installation of all elements that make up the child's foot and ankle joint, correction of biomechanics and the development of the correct walking skill in the postoperative period.
ENCHONDROMA AND CHONDROSARCOMA GI OF THE FOOT (CLINICAL OBSERVATION)
Authors: N.A. Koryshkov , I.I. Litvinov , V.V. Savgachev , A.S. Khodzhiev , A.F. Kolondaev
Published: September 2022

Abstract. Among all neoplasms of the skeleton, enchondroma is 12%, among benign bone neoplasms - 10 - 27%. Frequent localization of enchondroma - short tubular bones of the hands and feet. It is possible to transform an enchondroma of the foot into a chondrosarcoma. Clinical guidelines with a sufficiently substantiated clear diagnostic and therapeutic tactics for enchondromas and chondrosarcomas of the first degree have not been developed to date. The aim of the study was to evaluate the effectiveness of intralesional resection with adjuvant chemical ablation in the treatment of enchondroma and chondrosarcoma of the first degree of the toe on a clinical example. Materials and Methods: A 64-year-old female patient with long-term symptoms on the side of the 5th toe of the right foot and a significant progression of these symptoms over the past three months underwent removal of the soft tissue component of the tumor of this finger, intralesional resection of its distal phalanx, and adjuvant chemical ablation. Healing by primary intention. According to the histological examination, the excised tissue corresponded to an enchondroma with areas of degeneration into grade I chondrosarcoma. Results: The patient was followed up for two years after the operation. There was no tumor recurrence. The patient did not experience pain, difficulty walking, considered herself practically healthy. Conclusion: the above clinical observation confirms that intralesional resection with adjuvant chemical ablation in the treatment of enchondroma and chondrosarcoma of the first degree of the foot allows to avoid relapses and ensure good function in the near and long term.
PSYCHOLOGICAL ASPECTS OF FERTILITY OUTCOMES AMONG ADULTS’ CHILDHOOD CANCER SURVIVORS IN THE LONG TERM RECOVERY, PSYCOLOGICAL ASPECTS, REVIEW OF FOREGN LITERATURE
Authors: Y.A. Titova
Published: September 2022

Abstract. A fertility function disturbance is rather high in patients who had childhood cancer and it is caused by the toxic influence of chemotherapy and radiation treatment rather than the illness itself. The threat of fertility function loss may effect survivors’ mental health in the long term, but the knowledge about it is not enough. Purpose: to analyze foreign literature for studying fertility status in adult childhood cancer survivors and the psychological effects regarding this. General information. Fertility function disturbance is more prevalent in a group of patients who underwent cancer in childhood or adolescence than in the total population. It is caused by aggressive treatment of oncological disease. Risk of fertility dysfunction is a strong stressed factor and may lead to such conditions as anxiety, depression and other psychological consequences. All these conditions worsen quality of life, negatively influencing relationships. The moment to make a decision about cryoconservation of oocytes and sperm is a special problem for patients and their parents. This procedure should be performed before chemotherapy starts, meaning that families have little time to make a decision, and information about this side of treatment is not enough to understand the whole real risk of fertility loss in the future. Conclusion. A comprehensive psychological consulting for patients with oncological disease and their parents is necessary at the moment of diagnostics, it should give fully detailed information about the risk of fertility loss in the future and maintenance families while making a decision abou cryoconservation. During convalescence of these patients and their social adaptation to active regular life, psychological consulting plays a very important role in rehabilitation complex, including treatment of anxiety disorder and fears about fertility functions.
COMPARATIVE EVALUATION OF PHYSIOTHERAPEUTIC METHODS IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS OF MILD SEVERITY
Authors: A.V. Potoczkaya , A.M. Kovalevskij , V.A. Zheleznyak , E.G. Borisova , A.A. Komova
Published: September 2022

Abstract. Inflammatory periodontal diseases are socially significant diseases of the oral cavity, because they are on a third place of the frequency of seeking therapeutic dental care. The success of the treatment of chronic generalized periodontitis is assessed by the duration of remission of the disease. In this regard, the improvement of the algorithm of the treatment of chronic generalized periodontitis is an urgent task of modern dentistry. The purpose of the study is to identify the methods of physiotherapy in the complex treatment of mild chronic generalized periodontitis, which will contribute to the achievement of the longest remission of the disease. Material and methods. We observed 204 patients 30-50 years old of both sexes with a diagnosis of mild chronic generalized periodontitis, who were divided into 6 groups depending on the prescribed treatment. Patients underwent a survey, an objective examination, including an assessment of the following periodontal indices – periodontal self-assessment integrative index and gingival sulcus bleeding index. Results and discussion. There was found that exacerbation of chronic generalized periodontitis of mild severity occurs in a month in those patients who did not receive physiotherapy, after 3 months in those patients who received physiotherapy by one method (ascorbic acid electrophoresis or magnetotherapy, or the use of darsonvalisation), and after 6 months – in those patients who were treated using a combination of physiotherapeutic methods (ascorbic acid electrophoresis and darsonvalisation or ascorbic acid electrophoresis and magnetotherapy). Conclusion: the combination of physiotherapeutic methods in the complex treatment of chronic generalized periodontitis of mild severity allows achieving the longest remission.
STUDYING THE OSMOTIC ACTIVITY OF A POLYCOMPONENT REPARATIVE GEL
Authors: E.B. Nikiforova , K.I. Melkonyan , D.V. Veselova , A.G. Nechaeva , Y.A. Kozmai
Published: September 2022

Abstract. Hydrogel-based wound dressings are currently in demand due to their positive effect on reparative processes. The range of such is quite diverse and is represented by gelling agents of both synthetic and natural origin. The latter are most often biopolymers, among which collagen deserves special attention. The most important properties of collagen are its biocompatibility, low level of immunogenicity, ability to biodegrade, which leads to the formation of degradation products that stimulate cell proliferation and the biosynthesis of native collagen. Collagen has optimal physical characteristics, which is important for ensuring the structural and mechanical properties of the compositions. In addition, collagen has been successfully used as a carrier for other pharmacologically active substances. In this regard, the expediency of developing a multicomponent gel with a predictable reparative effect based on collagen and a thick extract of maize columns with stigmas was shown. This medicinal plant raw material has anti-inflammatory, antioxidant, immunotropic effects, which suggests its positive effect on tissue healing processes. One of the important properties of the reparative gel is its osmotic activity, which determines the ability to absorb exudate and cleanse the surface of the wound from purulent secretions, reduce tissue hyperthermia and inflammatory edema. The purpose of this study is to study the osmotic activity of a multicomponent gel of reparative action based on collagen and a thick extract of maize columns with stigmas. The object of the study was experimental samples of a polycomponent gel. Osmotic activity was studied by the method of equilibrium dialysis according to Kruvchinsky. For the purpose of a comparative assessment of the osmotic activity of a multicomponent gel, a control study was carried out in parallel under the same conditions for a 0.9% sodium chloride solution. The results obtained demonstrated the presence of hyperosmolar characteristics in the experimental samples of the polycomponent gel during the first four hours of dialysis, which allows us to predict its positive effect on the processes of cleansing damaged tissues from pathological secretions and their effective repair.
MORPHOLOGICAL ASPECTS OF FETAL MEMBRANE DAMAGE IN MISCARRIGE OF PREGNANCY BY RESULTS OF SCANNING ELECTRONIC MICROSCOPY
Authors: L.I. Dyatlova , T.N. Glukhova
Published: September 2022

Abstract. Currently, one of the most significant pathologies in obstetric practice is rupture of amniotic fluid in preterm pregnancy, which in more than 50% of cases precedes premature termination of pregnancy. This study is devoted to the study of the morphological foundations of the formation of insolvency of the membranes in preterm pregnancy. Using a Hitachi S-4500 scanning electron microscope at a magnification of 130 and 900 times, the ultrastructure of two fetal membranes (smooth chorion and amnion) was studied during physiological gestation and during pregnancy complicated by premature rupture of the fetal membranes with an anhydrous interval of not more than 6 hours and the absence of clinical and laboratory signs of the inflammatory process. The material was taken during a caesarean section. Tissue samples with dimensions of 1-4 mm are stained according to the Kranovsky method. It has been established that during a physiologically proceeding pregnancy, the outer layer of the amnion is represented by a cubic epithelium, which has a brush border on the apical part of the stellate shape. Amnion cells are tightly adjacent to each other. The inner layer of the amnion is represented by mesenchymal epithelium. The study of the ultrastructure of the smooth chorion during physiological pregnancy showed that its outer surface, in contact with the decidua, consists of tightly contacting cells with stellate microvilli. The inner surface of the smooth chorion, adjacent to the amnion, is represented by spongy tissue. The study of the ultrastructure of the fetal membranes during preterm pregnancy, complicated by prenatal rupture of amniotic fluid, made it possible to establish that the morphological basis of the failure of the fetal membranes is damage to the brush border of the amniotic epithelium and an increase in intercellular gaps in the amniotic membrane, which indicates the inferiority of the fetal membranes already at the stage of their formation.
THE ESSENTIAL OIL COMPOSITION AND ANTIRADICAL ACTIVITY OF SCOTS PINE CONES COLLECTED IN THE PERM REGION
Authors: D.K. Gulyaev , P.S. Mashchenko , V.D. Belonogova , A.S. Lekhanova
Published: September 2022

Abstract. Scots pine is a widespread plant on the territory of the Russian Federation. Scots pine cones are thought of as an advanced raw material for the research of the chemical composition and pharmacological activity. The object of this paper was the research of the essential oil component composition and antioxidative activity of young Scots pine cones collected in the Perm region. The samples of Scots pine cones were collected in the Yurlinsky, Ilyinsky, Permsky and Bardymsky districts of the Perm Region for the essential oil component composition research. The essential oil component composition was determined by the gas chromatograph with a mass selective detector Agilent 7890A. The antioxidative activity of raw materials infusions was determined by their ability to bind the free radical 2,2-diphenyl-1-picrylhydrazyl. As a result of the research, 10 components related to monoterpenes and sesquiterpenes were identified in the essential oil of Scots pine cones of all regions. The monoterpene fraction predominates in the essential oil of Scots pine cones in all districts of the research. The content of sesquiterpenes slightly increases in the essential oil of the more southern districts of the region, such as Permsky and Bardymsky. The content of sesquiterpenes in the essential oil of more southern districts grows mainly due to an increase of caryophyllene and humulene. The main component of Scots pine cones essential oil is the dicyclic monoterpene α-pinene. Basing on the results of the antioxidative activity determination, it was found that the infusions prepared from young pine cones collected in the Ilyinsky, Bardymsky and Permsky districts have the maximal ability to bind free radicals. The infusion of the pine cones from the Yurlinsky district has showed the least antioxidative activity, which can be ascribed to a high content of the monoterpene fraction in the essential oil.
THE STUDY OF THE TECHNOLOGICAL CHARACTERISTICS OF THE SUBSTANCE VMA-10-13 AND THE TECHNOLOGY OF MANUFACTURING TABLETS
Authors: D.S. Volokitina , S.V. Volokitin , A.M. Shevchenko
Published: September 2022

Abstract. Currently, intensive research is being conducted in the study of new biologically active substances for medical use that will be effective and safe for human use. Before the production of a medicinal product, the technological parameters and characteristics of a pharmaceutical substance must be carefully studied and scientifically substantiated. When creating and modernizing the technology of dosage forms, one of the most important stages is the assessment of bioavailability. It, in turn, depends on the physico-chemical properties of the active substance. The present work is devoted to the study of the technological properties of the original pharmaceutical substance of the quinazoline derivative, used as an active substance for the development of the composition and technology for obtaining a dosage form for oral use in the form of tablets using solid dispersion. The technological characteristics of a new biologically active compound –a derivative of quinazoline: 3-[2-(2-Methylphenylamino)-2-oxoethyl]-quinazoline-4(3H)–oh (laboratory code: VMA–10–13), capable of influencing pharmacological activity in the production of the dosage form, have been studied. The study examined key indicators: residual moisture, bulk density, flowability, ejection pressure, compressibility and disintegration of model tablets. The composition and technology of obtaining a solid dosage form (tablets) using a solid dispersion with improved biopharmaceutical characteristics have been developed. The main pharmaceutical and technological indicators of tablet quality are determined: average weight and disintegration. The data obtained allowed us to assume the content and course of further stages of pharmaceutical development.
OPTIMIZATION OF MANAGEMENT TACTICS FOR CONGENITAL HEART DISEASE, ENDOMETRIOSIS AND UTERINE FIBROID
Authors: O.B. Kalinkina , Yu.V. Tezikov , I.S. Lipatov , M.O. Mayorova
Published: September 2022

Abstract. Congenital heart defect tetrad Fallot is one of the most pressing problems of modern cardiac surgery. The tactics of managing such patients is also a problem, the solution of which is relevant not only for cardiologists and cardiac surgeons, but also for doctors of other specialties. The presence of concomitant gynecological pathology in patients with TF requires close attention to this category of patients of obstetricians and gynecologists. The study of this clinical situation made it possible to optimize the management tactics of a patient with CHD, OMC caused by uterine fibroids, endometriosis and anemia with the use of Buserelin- Long (an agonist of Hh-RG) for 6 months (3 months before surgery and 3 months after it) for the purpose of preoperative preparation and postoperative management. Relief of severe pelvic pain was noted already in the first month of treatment with Buserelin - Long. During the examination of the patient 3 months after the operation, no recurrence of endometriosis was detected. The patient noted good tolerability of the drug. Buserelin – Long, due to its pharmacodynamics, has no negative effect on lipid and carbohydrate metabolism, as well as the blood clotting system, which was its important advantage among all hormonal drugs that cannot be prescribed in this clinical case. Buserelin-Long can be recommended in a similar clinical situation to patients with CHD and OMC caused by uterine fibroids and endometriosis, when the metabolic neutrality of the drug is of paramount importance and allows optimizing the management tactics of patients with CHD, OMC caused by uterine fibroids, endometriosis and anemia.
THE CLINICAL COURSE FEATURES OF MYOCARDIAL INFARCTION, COMPLICATED BY ACUTE URINARY RETENTION, IN YOUNG AND MIDDLE-AGED MEN
Authors: B.A. Chumak , V.A. Reiza , A.S. Izmuhanov , V.V. Tupitcyn
Published: September 2022

Abstract. Relevance. Acute urinary retention (AUR) in myocardial infarction (MI) negatively affects the course and prognosis of the disease.
Aim. To evaluate the MI clinical course of AUR development during the acute and subacute periods of disease in men under 60 years old to improve prevention and outcomes.
Materials and methods. The study included men aged 19-60 years with type I myocardial in-farction. Patients were divided into two age-comparable groups: I - study group, with ACR - 22 patients; II - control, without urination disorders - 644 patients. A comparative analysis of the features of the medical history and clinical course in the selected groups were performed. Pear-son's Chi-square method was used to analyze the risks of ACR development.
Results of the study. The study group differed from the control group in a higher frequency of cardiac arrhythmias and conduction disorders at the onset of coronary artery disease (I: 61.9; II: 24.9%; p = 0.0007), higher incidence of multiple MI complications (100 and 44.0%; ; respectively; p < 0.0001), severe and extremely severe condition of patients (59.0 and 19.6%; p < 0.0001). Asystole (absolute risk: 42.1%; relative: 18.0; p < 0.0001), hydrothorax (41.7%; 15.9; p < 0.0001), the patient’s severe condition in the first hours of illness (30%; 36.5; p < 0.0001), and onset of CHD with heart rhythm and conduction disturbances (7.7%; 4.6; p = 0.0001) were the most significant ACR predictors.
Conclusion. Patients with ACR are characterized by a more severe MI course. Combinations of listed above factors indicate an increased risk of development this complication. It is advisable to use them for predictive modeling and the formation of risk groups for timely prevention.
THE SPIRITUAL FOUNDATION OF HUNTING CULTURE: TRADITIONAL AND MODERN AMONG THE INDIGENOUS PEOPLES OF YAKUTIA
Authors: G.S. Popova
Published: September 2022

Abstract. Comprehension of the image and naming of the spirit of hunt - known as Baai Barylah Bayanai - has high value nowadays. The spirit has an archetypal nature. Hunting today is losing its main function, gradually turning into a social attribute of a modern man. But hunting still has pedagogical potential. The goal of the research is to find out the attitude of the indigenous peoples of Yakutia to this image–phenomenon. A comparison is made between traditional and modern societies. The methods include theoretical analysis, comparison and logical analysis, interdisciplinary approach, sociological research. The author used a step-by-step transformation of the image of the spirit of hunting, outlining its active existence among modern representatives of northern ethnic communities. There is an obvious need to continue the intergenerational transmission of hunting cultural practices and hunting culture/hunting culture. It is established that this image has passed a full cycle of existence in historical and cultural terms. This cycle took place in the following sequence: anima /animus– totem – fetish. Nowadays, the Bayanai spirit is at the beginning of a new cycle of its existence – with an animistic beginning. The theoretical value of the study is to substantiate the process of formation of spiritual culture in the younger generation. The practical significance is in educating young hunters to upbring traditional respectful attitude to the spirit of hunting, the Bayanai.
PROFESSIONAL READINESS OF STUDENTS FOCUSED ON SELF-DEVELOPMENT
Authors: E.V. Golubevа
Published: September 2022

Abstract. The article is devoted to the problem of professional readiness of students focused and not focused on self-development. The theoretical analysis of the problem showed that professional activity is one of the main areas of self-development and begins to come to the fore from the moment, when a person chooses a future profession and when a person's professional readiness begins to form. Therefore, the study of professional readiness of self-development-focused students seems to be relevant. An empirical study was conducted with the participation of 57 technical students and using the following methods: «Readiness for self-development» (T.A. Ratanova, N.F. Shlyakhta) and «Questionnaire of professional readiness» (L.N. Kabardova). The following statistical methods were used: Mann-Whitney U-test, Fisher's exact test, r-Spearman correlation test. It has been established that the professional readiness of students focused on self-development is generally higher than that of students who are not focused on self-development (both in accordance with the chosen profession, and in those that do not correspond to it) and in its individual components (in particular, in the components "Skill” and “Attitude”). Such students, thanks to the desire for self-development, receive the necessary experience, which allows them to rate highly their own abilities for professional activity in general. It has also been proven that the components of professional readiness (“Skill”, “Desire”) correlate with areas of self-development (self-knowledge and self-improvement). The hypothesis that self-development-focused students more often choose a professional field for which they demonstrate greater professional readiness than non-self-development students has not been confirmed and requires further research, which may be a research perspective.
Luigi Mongeri: On dokuzuncu Yüzyıl Osmanlı İmparatorluğu’nda Bir Islahatçı ve “Şark Deliliği” Uzmanı
Authors: GÜNDOĞDU Cihangir
Published: September 2022

This article focuses on the early career of Luigi Mongeri, who was appointed as the chief physician to the Süleymaniye Mental Asylum in 1856 to treat mental illness and improve the living conditions of mentally ill patients in the nineteenth-century Ottoman Empire. It focuses on Mongeri's early career in Italy, investigates his involvement in Ottoman imperial patronage networks and their subsequent effects on his career, and finally explores the reform program he implemented at Süleymaniye. While in the Ottoman Empire, Mongeri appeared as a reformist who claimed to improve the living conditions and treatment of patients by the use medical statistics, abolishing the use of shackles, etc. At the same time in Europe—and especially in France, which was one of the important centers of alienist medicine at the time— he presented himself as an expert on "oriental insanity,” a claim which gained him access to international medical circles and organizations.
Modern Linguistics in Contemporary Studies of the Arabic Language
Authors: SAĞ ŞENCAL Esma , BENLİ Ali
Published: September 2022

Contemporary Arabic linguists differ in terms of including the Classical Arabic language (CAL) tradition and linguistics in their studies. Assuming that there are two different thought systems with different assumptions regarding existence and knowledge, we can categorize these various studies under the following three categories: (1) studies that examine Arabic through linguistics, (2) studies that examine Arabic through CAL sciences, and (3) studies examining Arabic using both language approaches. The aim of this study is to reveal the existence of the first category. Due to the limitations of the study, only the first category has been focused. Studies of the first category are examined under four subheadings: (1) Studies introducing linguistics to the Arab world, (2) studies in theoretical linguistics, (3) studies in other linguistic fields such as applied linguistics, sociolinguistics, and (4) Arabic linguistic journals. In conclusion, these linguists’ preference of linguistics over CAL tradition is justified with their acceptance of scientific progress as cumulative, continuous, and linear. In addition, it is noticed that these linguists did not completely ignore the CAL tradition. Accordingly, it is discussed that the possible reasons for this may be the aim of building a bridge between the Arabic reader and linguistics, since the CAL tradition has a rich background and is still influential in the Arab world.
SAID NURSI'S OPPOSITION IN THE LATE OTTOMAN PERIOD
Authors: ADAK Reşat
Published: September 2022

Bediüzzaman Said Nursi, çağdaşı olduğu Osmanlı İmparatorluğu'ndaki siyasi, sosyal, entellektüel ve eğitim koşullarından etkilenmiş ve bu konularda fikir beyan etmiş bir alim ve ıslahatçıdır. O, Osmanlı Devleti’nin dağılabileceğini gördüğünden Sultan Abdulhamid ve hükümetini uyarmış ve gerekli ıslahatların ilan edilmesini talep etmiştir. Nursi’nin temel taleplerini şu başlıklar altında toplamak mümkündür: 1. Kürt coğrafyasında ihmal edilen sosyo-politik durumların düzeltilmesi ve dini ilimler ile pozitif bilimlerin okutulacağı “Medresetü’z-Zehra” adında bir üniversitenin kurulması. 2. İslam adına uygulanan istibdattan vazgeçilmesi ve İslam hukuku dairesinde bir hürriyetin ilan edilmesi. 3. Yıldız Sarayı’nın İslami bir üniversiteye dönüştürülmesi ve Avrupa bankalarında bulunan altın ve dövizlerin devlete iade edilmesi. 4. Osmanlı devletinin “Birleşik İslam Cumhuriyetleri” tarzında bir yönetim şeklini benimsemesi ve her halkın kendi dili ile hükümet ve meclisini kurması. Nursi’nin bu talepleri o dönemde uygulanmamışsa da günümüzde hala ilgi çekmekte ve geniş takipçi kitlesi tarafından benimsenmektedir.
Tuz stresi altındaki tütün bitkisine yapraktan silisyum (Si) uygulamalarının etkileri
Authors: KINAY Ahmet , ERDEM Halil
Published: September 2022

Tuzluluk bitkilerde verim ve kaliteyi olumsuz yönde etkileyen en önemli abiyotik stres faktörleri arasında yer almasına karşılık, silisyum (Si) bitkilerde stres faktörlerini azaltan bir element olarak bilinmektedir. Bu çalışmada tütün bitkisinde tuz stresinin neden olduğu hasara karşı yapraktan Si uygulamalarının koruyucu etkisinin araştırılması amaçlanmıştır. Çalışmada dört farklı (0, 1.5, 3, 4.5 ve 6 dS m-1) tuz dozu altında yetiştirilen Canik 190/5 tütün çeşidine yapraktan 1 ve 2 defa Si uygulamaları yapılmıştır. Tüm bitki kuru madde verimi, Na, K, Ca, Mg, P konsantrasyonu ile K/Na oranı incelenmiştir. Artan dozlarda tuz uygulamaları tütün bitkisinin yeşil aksam kuru madde veriminde azalmaya neden olurken, yapraktan Si uygulamaları kuru madde verimlerindeki azalmayı yavaşlatmıştır. Kontrol uygulamalarının ortalama bitki kuru madde verimi 6.42 g bitki-1 iken, yapraktan 1 defa Si uygulamasında bu değer 6.65 g bitki-1’e çıkmış, yapraktan 2 defa Si uygulamasında ise 7.08 g bitki-1’e çıkmıştır. Silisyum uygulamaları tütün bitkisinin Na konsantrasyonlarında azalmaya neden olurken, K konsantrasyonları ile K/Na oranlarında artışa neden olarak bitkinin tuza karşı dayanıklılığını arttırmıştır. Çalışma sonucunda; tütün bitkisinin tuz stresine karşı dayanıklılığının arttırılmasında yapraktan Si uygulamalarının pozitif etkisinin olabileceği, uygulama sayısı bakımından ise yapraktan 2 defa uygulamanın daha etkili olduğu ortaya çıkmıştır.
Studi Hasil dan Kualitas Tiga Varietas Terung (Solanum melongena L.) Pada Beberapa Jenis Media Tanam
Authors: Hasnidar Hasnidar , Yusuf N Muhammad , Khaidir Khaidir , Nazaruddin Muhammad
Published: September 2022

Permintaan pasar terhadap terung terus meningkat seiring dengan bertambahnya kesadaran masyarakat terhadap nilai gizi, namun produksinya sampai saat ini belum mampu memenuhi kebutuhan tersebut. Rendahnya produksi terung dipengaruhi oleh pemanfaatan teknologi budidaya yang belum optimal. Penelitian ini bertujuan untuk mempelajari dan mengevaluasi kualitas pertumbuhan 3 varietas terung pada media tanam yang berbeda. Metode penelitian menggunakan Rancangan Acak Kelompok (RAK) Faktorial. Faktor pertama adalah varietas terung: Mustang F1 (V1), Lezata F1 (V2) dan Antaboga F1 (V3). Faktor kedua adalah media tanam: Kontrol (M0), tanah + kotoran sapi 3:1 (M1) dan tanah + arang sekam 3:1 (M2).  Secara umum hasil penelitian menunjukkan bahwa perlakuan varietas dan media tanam berpengaruh terhadap komponen produksi dan terdapat interaksi antara perlakuan varietas dan media tanam terhadap indeks panen.
Kerentanan Relatif Jenis Beras Terhadap Sitophilus oryzae L. (Coleoptera: Curculionidae) Pada Keadaan Kadar Air Rendah
Authors: Susanti Susi , Hendrival Hendrival , Usnawiyah Usnawiyah , Hafifah Hafifah , Nazaruddin Muhammad
Published: September 2022

Hama kumbang bubuk beras, Sitophilus oryzae (Coleoptera: Curculionidae) merupakan hama primer dan menyebabkan kerusakan pada beras di penyimpanan.  Kerusakan beras masih terjadi selama di penyimpanan pada kadar air rendah. Tujuan penelitian yaitu mempelajari kerentanan dan kerusakan jenis beras pada keadaan kadar air rendah serta interaksinya setelah diinfestasi S. oryzae. Penelitian dilaksanakan dalam bentuk faktorial pola Rancangan Acak Lengkap dengan perlakuan jenis beras dan kadar air. Jenis beras yaitu beras putih, beras merah, beras ketan putih, dan beras ketan hitam, sedangkan kadar air yaitu 10 dan 12%. Parameter pengamatan yaitu jumlah F1, median waktu perkembangan, indeks kerentanan, dan susut berat beras. Untuk mengukur kekuatan hubungan antar parameter pengamatan ditentukan dengan analisis korelasi. Hasil penelitian menunjukkan bahwa kadar air beras sebesar 10% masih berpengaruh terhadap jumlah F1, perkembangan, kerentanan beras, dan susut berat beras, namun masih lebih rendah dibandingkan kadar air 12%. Katagori kerentanan beras bervariasi dari moderat sampai rentan. Jumlah F1, indeks kerentanan, susut berat paling tinggi dan median waktu perkembangan paling singkat dijumpai pada beras merah. Interaksi antara beras merah dengan kadar air 10% masih berdampak terhadap kerentanannya dan tergolong rentan, sedangkan pada beras ketan putih tergolong moderat. Semua jenis beras dengan kadar air 12% tergolong rentan dan rentan sampai sangat rentan terhadap hama S. oryzae.
Pengaruh Posisi Skarifikasi dan Asam Sulfat (H2SO4) Terhadap Viabilitas Benih Sirsak (Annona muricata L.)
Authors: Siregar Eka Pratika Duri , Nazimah Nazimah , Safrizal Safrizal , Nilahayati Nilahayati , Khaidir Khaidir
Published: September 2022

Kendala dalam pembudidayaan sirsak yaitu sirsak memiliki kulit biji yang keras sehingga menyebabkan biji impermeabel terhadap gas dan air yang mengakibatkan terhambatnya perkecambahan. Pematahan dormansi benih sirsak dapat dilakukan dengan skarifikasi serta perendaman asam sulfat. Penelitian ini bertujuan untuk mengetahui pengaruh posisi skarifikasi dan konsentrasi asam sulfat terhadap viabilitas biji sirsak. Penelitian ini dilakukan di Laboratorium Agroekoteknologi Fakultas Pertanian Universitas Malikussaleh. Penelitian menggunakan Rancangan Acak Lengkap (RAL) pola faktorial terdiri dari dua faktor dengan tiga ulangan. Faktor pertama posisi skarifikasi terdiri dari S0 (tanpa skarifikasi), S1 (skarifikasi pangkal), S2 (skarifikasi tengah), S3 (skarifikasi ujung). Faktor kedua konsentrasi asam sulfat terdiri dari K0 (0%), K1 (10%), K2 (20%), K3 (30%). Hasil penelitian menunjukkan bahwa terdapat interaksi antara perlakuan posisi skarifikasi dan konsentrasi asam sulfat (H2SO4) pada parameter daya berkecambah dan kecepatan tumbuh. Kombonasi S0K1 (tanpa skarifikasi dan asam sulfat 10%) sudah mampu meningkatkan daya berkecambah dan kecepatan tumbuh benih sirsak. Perlakuan skarifikasi berpengaruh terhadap potensi tumbuh maksimum, daya berkecambah, kecepatan tumbuh, keserempakan tumbuh, indeks vigor dan berat basah. Perlakuan tanpa skarifikasi sudah mampu meningkatkan potensi tumbuh maksimum, daya berkecambah, kecepatan tumbuh, keserempakan tumbuh, indeks vigor, berat basah. Perlakuan konsentrasi tidak berpengaruh terhadap viabilitas benih sirsak.