bluuebunny/crossref_metadata_2025 huggingface dataset:
VIOLÊNCIA DOMÉSTICA CONTRA OS IDOSOS: UMA REVISÃO INTEGRATIVA
Authors: Da Silva Bruna Isoppo , Filgueiras Letícia Pilotto Casagranda , Eberhardt Emily Da Silva , Baltazar Atalíbio Felipe Becker
Published: November 2020

Introdução: A violência doméstica se destaca como um dos principais problemas de saúde pública, principalmente, em nosso país. Além de o tema ser pouco debatido, as produções científicas são escassas e os índices de violência estão aumentando cada dia mais. Objetivo: Analisar as produções bibliográficas acerca de idosos vítimas de violência doméstica, bem como caracterizar o perfil destes idosos, identificar os agressores e os principais tipos de violências sofridas. Métodos: Trata-se de um estudo de revisão integrativa da literatura, com pesquisas realizadas nas bases de dados BDenf, LILACS, SciELO, cujos artigos foram publicados no período de 2006 a 2016. Resultados: Evidenciou-se que as principais vítimas de maus-tratos na terceira idade são do sexo feminino, de 60 a 69 anos, analfabetas ou com baixa escolaridade, casadas e aposentadas. Como principal morbidade, destaca-se a Diabetes Mellitus, como principais agressores têm-se os cônjuges ou membros da família e o principal tipo de violência relatada, foi a psicológica. Conclusão: Com o aumento da população idosa, os prejuízos decorrentes da violência doméstica sofrida na terceira idade refletem diretamente em nosso cotidiano e está se tornando um grave problema de saúde pública. Ainda são escassos os estudos na área e as pesquisas pouco aprofundadas, tornando-se necessário, maior atenção das políticas públicas, programas educacionais e atenção por parte das equipes de saúde, a fim de que estes idosos não continuem sendo alvo de maus-tratos no seu ambiente familiar.
O HOMEM NO CONTEXTO GRAVÍDICO-PUERPERAL: UMA REVISÃO INTEGRATIVA
Authors: Dos Passos Eliane , Pedron Cecília Drebes
Published: November 2020

Este estudo objetiva identificar as evidências do envolvimento dos homens no ciclo gravídico-puerperal. Trata-se de uma revisão integrativa que teve como questão norteadora: Qual o envolvimento dos homens no ciclo gravídico-puerperal? Os artigos foram coletados na Biblioteca Virtual em Saúde com os descritores e operadores boleanos “percepção” and “pai” and “parto”; “pai” and “parto”; e “pai” and “gravidez”. Após a aplicação dos critérios de inclusão e exclusão a busca resultou na seleção de 12 estudos. Os achados foram analisados em categorias temáticas, tendo aproximações com a Análise de Conteúdo. As categorias temáticas que emergiram delineiam a participação do homem no ciclo gravídico-puerperal demonstrando as interconexões entre suas diferentes fases. Os resultados também inseriram o homem no acompanhamento do parto e as conexões com a gestante, bem como a interação no pós-parto, aproximando com o recém-nascido. Sendo assim, o estudo demonstrou que o homem possui espaço de participação no ciclo gravídico-puerperal, pois o mesmo oferece o apoio necessário ao grupo familiar.
Pavimentación con asfalto natural “MAPIA”. Estudio de caso: Proyecto mejoramiento de la vía El Diviso – Torcoroma del municipio de San Martin, Cesar
Authors: Gómez-Galván Marcela , Gallardo-Amaya Romel , Macgregor-Torrado Agustín Armando
Published: November 2020

El “MAPIA” es una mezcla asfáltica compuesta principalmente de arenas finas y asfalto natural que puede usarse en vías con diferentes niveles de tránsito en cualquiera de las capas de la estructura del pavimento. El propósito de esta investigación se enfocó en la caracterización de este material y su proceso de instalación para el mejoramiento de un tramo de vía del municipio de San Martin, Cesar. Inicialmente se realizó la identificación de las propiedades del MAPIA tales como: composición porcentual de los materiales, índice de penetración, ductilidad del asfalto, punto de ablandamiento y viscosidad absoluta. Posteriormente, una vez adecuado el MAPIA con la incorporación de triturado ¾”, se procedió a la instalación de la mezcla con equipo tradicional. Como resultado de este estudio, se encontró que el material MAPIA, posee características semejantes a un asfalto 80/100, con una composición de material granular fino entre el 87% y 90% y asfalto natural entre 9% y 12%. Sin embargo, los resultados sugieren que este tipo de material presenta alta susceptibilidad a cambiar su penetración ante cambios de temperatura. Así mismo no requiere de maquinaria especializada, lo cual reduce el consumo energético en la aplicación y también permite una rápida apertura del tráfico.
A comparative study in flexure and shear design of spread footings
Authors: Freitas de Almeida Iago , Castelo Branco de Noronha Campos Maurício , Almeida de Oliveira Romilde
Published: November 2020

The design of spread footings is a field widely explored in structural engineering being the flexure and shear design verified by the use of codes. The objective of this paper consists in a comparative study of spread footing design between the Brazilian’s code, Eurocode and American’s code. The methodology considered an analytical analysis with three different examples in the flexure and shear design of the spread footings with different loads and footing height. The results show that the American’s code presented the minimum required value of reinforcement rates ​​in all examples and also was the only code that verified the punching and shear effect for all studied cases. In Eurocode flexure design, the results show that in the most examples, the reinforcement rate is higher than that considered by the other codes. The Brazilian code presented an inconsistency in the verification of the punching effect for one of the studied examples, requiring, therefore, a review and a modification of the code.
Vulnerabilidad sísmica de centros poblados: estudio de caso
Authors: Criado-Rodríguez Daniela Marcela , Pacheco-Vergel William Alonso , Afanador-García Nelson
Published: November 2020

Este trabajo de investigación tuvo por objetivo determinar el nivel de vulnerabilidad sísmica de las viviendas del barrio Cristo Rey del municipio de Ocaña, Norte de Santander, aplicando la metodología de la Agencia Federal para la Gestión de Emergencias (FEMA), FEMA P-154. El barrio que constituyen el caso de estudio no se aleja de la realidad de cualquier otro barrio en Colombia, donde los asentamientos se han dado sin tener en cuenta ninguna proyección urbanística ni mucho menos estudios más completos como, microzonificación sísmica. Los tipos de construcciones encontradas fueron viviendas construidas con sistemas de mampostería simple y algunas con mampostería confinada, con irregularidades en planta, vertical y planta-vertical, además de riesgo geológico al desplazamiento y un alto porcentaje de viviendas construidas antes de 1984. El resultado encontrado fue viviendas en los tres niveles de vulnerabilidad sísmica, siendo el mayor porcentaje el nivel de vulnerabilidad sísmica alto.
Proposals for continued research to determine older adults’ falls risk
Authors: Pettersson Beatrice , Nordin Ellinor , Ramnemark Anna , Lundin-Olsson Lillemor
Published: November 2020

Early detection of older adults with an increased risk of falling could enable early onset of preventative measures. Currently used fall risk assessment tools have not proven sufficiently effective in differentiating between high and low fall risk in community-living older adults. There are a number of tests and measures available, but many timed and observation-based tools are performed on a flat floor without interaction with the surrounding. To improve falls prediction, measurements in other areas that challenge mobility in dynamic conditions and that take a persons’ own perception of steadiness into account should be further developed and evaluated as single or combined measures. The tools should be easy to apply in clinical practice or used as a self-assessment by the older adults themselves.
Insertion of an SVA Element in MSH2 as a Novel Cause of Lynch Syndrome
Authors: Yang Ciyu , Li Yirong , Trottier Magan , Farrell Michael , Rai Vikas , Salo-Mullen Erin , Gallagher David , Stadler Zsofia K. , Klift Heleen van der , Zhang Liying
Published: November 2020

Germline mutations in the DNA mismatch repair (MMR) genes cause Lynch
syndrome (LS). Insertions of retrotransposons in MMR genes have been
reported as a rare cause of LS. Here, we present a novel SINE-VNTR-Alu
(SVA) insertion in exon 12 of MSH2 in an individual with early-onset
colorectal cancer and strong LS family history. RT-PCR analysis
indicated a larger aberrant MSH2 transcript in one of the family
members. MSK-IMPACT next-generation sequencing testing and long-range
PCR revealed an insertion in MSH2 exon 12 at the c.1972 position in an
antisense orientation. The insertion was further characterized as an SVA
element approximately 3 kb in length, belonging to the SVA_F1 family of
retrotransposons.
A Multi-sensor Evaluation of Precipitation Uncertainty for Landslide-triggering Storm Events
Authors: Culler Elsa , Badger Andrew , Minear J. , Tiampo Kristy , Zeigler Spencer , Livneh Ben
Published: November 2020

Extreme precipitation can have profound consequences for communities,
resulting in natural hazards such as rainfall-triggered landslides that
cause casualties and extensive property damage. A key challenge to
understanding and predicting rainfall-triggered landslides comes from
observational uncertainties in the depth and intensity of precipitation
preceding the event. Practitioners and researchers must select among a
wide range of precipitation products, often with little guidance. Here
we evaluate the degree of precipitation uncertainty across multiple
precipitation products for a large set of landslide-triggering storm
events and investigate the impact of these uncertainties on predicted
landslide probability using published intensity-duration thresholds. The
average intensity, peak intensity, duration, and NOAA-Atlas return
periods are compared ahead of 228 reported landslides across the
continental US and Canada. Precipitation data are taken from four
products that cover disparate measurement methods: near real-time and
post-processed satellite (IMERG), radar (MRMS), and gauge-based
(NLDAS-2). Landslide-triggering precipitation was found to vary widely
across precipitation products with the depth of individual storm events
diverging by as much as 296 mm with an average range of 51 mm. Peak
intensity measurements, which are typically influential in triggering
landslides, were also highly variable with an average range of 7.8 mm/hr
and as much as 57 mm/hr. The two products more reliant upon ground-based
observations (MRMS and NLDAS-2) performed better at identifying
landslides according to published intensity-duration storm thresholds,
but all products exhibited hit-ratios of greater than 0.56. A greater
proportion of landslides were predicted when including only
manually-verified landslide locations. We recommend practitioners
consider low-latency products like MRMS for investigating landslides,
given their near-real time data availability and good performance in
detecting landslides. Practitioners would be well-served considering
more than one product as a way to confirm intense storm signals and
minimize the influence of noise and false alarms.
On some connection results between Laguerre polynomials via third-order differential operator
Authors: Aloui Baghdadi , chammam wathek , Souissi Jihad
Published: November 2020

Let
$\{L^{(\alpha)}_n\}_{n\geq
0}$, ($\alpha\neq-m, \
m\geq1$), be the monic orthogonal sequence of Laguerre
polynomials. We give a new differential operator, denoted here
$\mathscr{L}^{+}_{\alpha}$,
raises the degree and also the parameter of
$L^{(\alpha)}_n(x)$. More precisely,
$\mathscr{L}^{+}_{\alpha}L^{(\alpha)}_n(x)=L^{(\alpha+1)}_{n+1}(x),
\ n\geq0$. As an illustration, we give
some properties related to this operator and some other operators in the
literature, then we give some connection results between Laguerre
polynomials via this new operator.
Asymmetric sulfoxidation of thioether catalyzed by soybean pod peroxidase to form enantiopure sulfoxide in water-in-oil microemulsions: kinetic model
Authors: Zhang yuanyuan , Li Huiling , Wang Zhiyong , Li Depeng , Gao Xin Xin
Published: November 2020

The asymmetric sulfoxidation catalyzed by soybean pod peroxidase (SPP)
in water-in-oil microemulsions were carried out with the yield of
91.56% and e.e of 96.08% at the activity of SPP of 3200 U ml-1 and 50℃
for 5 h. The mechanism with a two-electron reduction of SPP-I is
accompanied with a single-electron transfer to SPP-I and nonenzymatic
reactions, indicating that three concomitant sub-mechanisms contribute
to the asymmetric oxidation involving five enzymatic and two
nonenzymatic reactions, which can represent the asymmetric sulfoxidation
of organic sulfides to form enantiopure sulfoxides. With 5.44% of the
average relative deviation, a kinetic model fitting experimental data
very well was developed. The enzymatic reactions may follow ping-pong
mechanism with substrate inhibition of H2O2 and product inhibition of
esomeprazole, while nonenzymatic reactions, a power law. Those results
indicate that SPP with a lower cost and higher thermal stability may be
used as an effective substitute for Horseradish Peroxidase.
The Endangered White Sands pupfish (Cyprinodon tularosa) genome reveals low diversity and heterogenous patterns of differentiation
Authors: Black Andrew , Willoughby Janna , Brüniche-Olsen Anna , Pierce Brian , DeWoody Andrew
Published: November 2020

The White Sands pupfish (Cyprinodon tularosa), endemic to New Mexico in
Southwestern North America, is of conservation concern due in part to
invasive species, chemical pollution, and groundwater withdrawal.
Herein, we developed a high quality draft reference genome and use it to
provide biological insights into the evolution and conservation of C.
tularosa. Specifically, we localized microsatellite markers previously
used to demarcate Evolutionary Significant Units, evaluated the
possibility of introgression into the C. tularosa genome, and compared
genomic diversity among related species. The de novo assembly of PacBio
Sequel II error-corrected reads resulted in a 1.08Gb draft genome with a
contig N50 of 1.4Mb and 25,260 annotated protein coding genes, including
95% of the expected Actinopterigii conserved orthologs. Many of the
previously described C. tularosa microsatellite markers fell within or
near genes and exhibited a pattern of increased heterozygosity near
genic areas compared to those in intergenic regions. Genetic distances
between C. tularosa and the widespread invasive species C. variegatus,
which diverged ~1.6-4.7 MYA, were 0.027 (nuclear) and
0.022 (mitochondrial). Nuclear alignments revealed putative tracts of
introgression that merit further investigation. Genome-wide
heterozygosity was markedly lower in C. tularosa compared to estimates
from related species, likely because of smaller long-term effective
population sizes constrained by their isolated and limited habitat.
These population inferences, generated from our new genome assembly,
provide insights into the long term and contemporary White Sands pupfish
populations that are integral to future management efforts.
Association between CYP2D6 genotype and vortioxetine exposure and therapeutic failure - a retrospective, cohort study
Authors: Frederiksen Trine , Smith Robert , Jukić Marin , Molden Espen
Published: November 2020

The antidepressant vortioxetine is primarily metabolised by the
polymorphic enzyme CYP2D6. The objective of this study was to
investigate the effect of CYP2D6 genotype on exposure and therapeutic
failure of vortioxetine. The analysis included data from
CYP2D6-genotyped patients (N=458) on vortioxetine treatment from a
Norwegian therapeutic drug monitoring database. Compared with CYP2D6
normal metabolizers (NMs; N=242), vortioxetine exposure was 3.0-fold
(p<0.001) increased in poor metabolizers (PMs; N=35), 1.5-fold
(p<0.001) increased in intermediate metabolizers (IMs; N=173),
and not significantly changed (p=0.21) in ultra-rapid metabolizers (UMs;
N=8). Compared with NMs, treatment switch from vortioxetine to
alternative antidepressants was 8.0-fold (95%CI: 2.0-32.3, p=0.001)
more frequent among PMs and 12.7-fold (95%CI: 1.1-94.9, p=0.02) more
frequent among the CYP2D6 UMs. In conclusion, CYP2D6 genotype was
associated with significant changes in vortioxetine exposure and may
also be associated with risk of therapeutic failure.
Primary cardiac hemangioendothelioma of the right ventricle
Authors: Chen Xiaoyan , Fang Jianxiu , Yang Qingmei , Guo Haifeng
Published: November 2020

Primary cardiac hemangioendothelioma is a very rare low-grade
malignancy. We present a case of a 41-year-old female patient with a
huge primary cardiac hemangioendothelioma that arose from the right
ventricle was recurred after being removed, and the diagnostic images
given by echocardiography.
Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGFβ1 Signaling Activation through the Aryl Hydrocarbon Receptor-RhoA Axis in Asthma
Authors: Wang Eryi , Tu Wei , Do Danh , Bhatti Shehar , Yang Liteng , Sun Xizhou , Xu Damo , Yang Pingchang , Huang Shau-Ku , Gao Pei-Song , Liu Zhigang
Published: November 2020

Background: We have previously demonstrated that benzo(a)pyrene (BaP)
co-exposure with dermatophagoides group 1 allergen (Der f 1) can
potentiate Der f 1-induced airway inflammation. We sought to investigate
the molecular mechanisms underlying the potentiation of BaP exposure on
Der f 1-induced airway inflammation. Methods: BaP co-exposure with Der f
1-induced activation of TGFβ1 signaling was analyzed in airway
epithelial cells (HBECs) and in asthma mouse model. The role of aryl
hydrocarbon receptor (AhR) and RhoA in BaP co-exposure-induced TGFβ1
signaling was investigated. AhR binding sites in RhoA were predicted and
experimentally confirmed by luciferase reporter assays. The role of RhoA
in BaP co-exposure-induced airway hyper-responsiveness (AHR) and
allergic inflammation was examined. Results: BaP co-exposure potentiates
Der f 1-induced TGFβ1 signaling activation in HBECs and in the airways
of asthma mouse model. The BaP co-exposure-induced the activation of
TGFβ1 signaling was attenuated by either AhR antagonist CH223191 or AhR
knockdown in HBECs. Furthermore, AhR knockdown led to the reduction of
BaP co-exposure-induced active RhoA. Inhibition of RhoA signaling with
fasudil, a RhoA/ROCK inhibitor, suppressed BaP co-exposure-induced TGFβ1
signaling activation. This was further confirmed in HBECs expressing
constitutively active RhoA (RhoA-L63) or dominant negative RhoA
(RhoA-N19). Luciferase reporter assays showed prominently increased
promoter activities for the AhR binding sites in the promoter region of
RhoA. Inhibition of RhoA suppressed co-exposure-induced AHR,
Th2-associated airway inflammation and TGFβ1 signaling activation in
asthma. Conclusions: Our studies identified a functional axis of
AhR-RhoA that regulates TGFβ1 signaling activation, leading to allergic
airway inflammation and asthma.
Calmodulin-binding transcription activator AtSR1/CAMTA3 fine-tunes plant immune response by transcriptional regulation of the salicylate receptor NPR1
Authors: Yuan Peiguo , Tanaka Kiwamu , Poovaiah B.W.
Published: November 2020

Calcium signaling regulates salicylic acid (SA)-mediated immune response
through calmodulin-meditated transcriptional activators, AtSRs/CAMTAs,
but its mechanism is not fully understood. Here, we report an
AtSR1/CAMTA3-mediated regulatory mechanism involving the expression of
the SA receptor, NPR1. Transcriptional expression of NPR1 increased in
knockout mutant, atsr1, independently of SA biosynthesis. AtSR1 directly
bound to a CGCG box in the NPR1 promotor. The atsr1 mutant exhibited
resistance to the virulent strain of Pseudomonas syringae pv. tomato
(Pst), however it was susceptible to an avirulent Pst strain carrying
avrRpt2, due to the failure of the induction of hypersensitive
responses. These resistant/susceptible phenotypes in the atsr1 mutant
were reversed in the npr1 mutant background, suggesting that AtSR1
regulates NPR1 as a downstream target during plant immune response. The
virulent Pst strain triggered a transient elevation in intracellular
Ca2+ concentration, whereas the avirulent Pst strain triggered a
prolonged change. The distinct Ca2+ signatures were decoded into the
regulation of NPR1 expression through AtSR1’s IQ motif binding to
calcium-free-CaM2, while AtSR1’s calmodulin-binding domain binding to
calcium-bound-CaM2. These observations reveal a role for AtSR1 as a
Ca2+-mediated transcription regulator for controlling the NPR1-mediated
plant immune response.
Natural variation reveals that OsFLA2 controls flag leaf angle in rice (Oryza sativa L.)
Authors: Dang Xiaojing , Hu Changmin , Xu Lei , Zhang Ying , Wang Dezheng , Jiang Jianhua
Published: November 2020

Flag leaf angle (FLA) is an important outcrossing trait affecting the
hybrid seed production in rice (Oryza sativa L.). Natural variation of
FLA has been reported in rice, but the molecular basis for this
variation is largely unknown. Here we investigated the phenotypic values
of FLA in 353 rice natural accessions in six environments, which
indicated rich phenotypic variation. We performed a genome-wide
association study on FLA using 1.3 million single nucleotide
polymorphism (SNPs). A total of 37 SNPs were identified significantly
associated with FLA, of which 27 were located in previously reported
QTLs/Genes and 10 were novel. We identified two causal gene loci for
FLA, OsFLA6 and OsFLA2; OsFLA6 was co-localized with the gene OsLIC. In
addition, the accessions with large and small FLA values have
corresponding high and low OsFLA6 expression. We also confirmed that the
allele OsFLA2TT increased the FLA compared with that of the isogenic
line carrying allele OsSYL2CC by transgenic complementation experiment.
The allele frequencies of OsFLA6GG and OsFLA2TT decreased gradually with
an increase in latitude in the Northern Hemisphere. Our results should
facilitate the improvement of FLA of parents of hybrid rice.
Protein kinases mediate anti-inflammatory effects of cannabidiol and estradiol against high glucose in cardiac sodium channels
Authors: Fouda Mohamed , Ruben Peter
Published: November 2020

Background and purpose. Cardiovascular anomalies are predisposing
factors for diabetes-induced morbidity and mortality. Recently, we
showed that high glucose induces changes in the biophysical properties
of Nav1.5 that could be strongly correlated to diabetes-induced
arrhythmia. However, the mechanisms underlying hyperglycemia-induced
inflammation, and how inflammation provokes cardiac arrhythmia, are not
well understood. We hypothesized that inflammation could mediate the
high glucose-induced biophyscial changes on Nav1.5 through protein
phosphorylation by protein kinases A and C. We also hypothesized that
this signaling pathway is, at least partly, involved in the
cardiprotective effects of CBD and E2. Experimental approach. To test
these ideas, we used Chinese hamster ovarian (CHO) cells transiently
co-transfected with cDNA encoding human Nav1.5 α-subunit under control,
a cocktail of inflammatory mediators or 100 mM glucose conditions (for
24 hours). We used electrophysiological experiments and action potential
modelling. Key Results. Inflammatory mediators, similar to 100 mM
glucose, right shifted the voltage dependence of conductance and steady
state fast inactivation and increased persistent current leading to
computational prolongation of action potential (hyperexcitability) which
could result in long QT3 arrhythmia. In addition, activators of PK-A or
PK-C replicated the inflammation-induced gating changes of Nav1.5.
Inhibitors of PK-A or PK-C, CBD or E2 mitigated all the potentially
deleterious effects provoked by high glucose/inflammation. Conclusions
and implications. These findings suggest that PK-A and PK-C may mediate
the anti-inflammatory effects of CBD and E2 against high glucose-induced
arrhythmia. CBD, via Nav1.5, may be a cardioprotective therapeutic
approach in diabetic postmenopausal population.
Estrogen receptor alpha inhibits mesenchymal and amoeboidal movement of liver cancer cell via G protein subunit alpha 12
Authors: Yun Jessica , Heo Mi Jeong , Kim Yun Seok , Kim Min Joo , Moon Aree , Kim Sang Geon
Published: November 2020

Background and Purpose Hepatocellular carcinoma (HCC) is the second most
common cancer worldwide, demonstrating aggressiveness and mortality more
frequently in men than in women. Despite reports regarding the
inhibitory ability of estrogen receptor alpha (ERα, ESR1) in certain
cancer progression, targets and the basis of underlying gender disparity
in HCC worsening remain elusive. Experimental Approach Human HCC samples
were used for immunoblottings and immunohistochemistry. Estradiol (E2)
was treated to HCC cell lines and were evaluated by immunoblottings,
polymerase chain reaction, immunofluorescence, and live imaging. Key
Results Here, we report the ability of ERα to transcriptionally inhibit
G protein subunit alpha 12 (Gα12). First, using human samples and public
database, the expression of ERα and Gα12 in HCC was examined. Then,
quantitative real-time PCR, chromatin immunoprecipitation-assay,
luciferase assay, and immunoblottings confirmed the inhibitory ability
of ERα on Gα12 and EMT. Additionally, we found microRNA-141 and -200a as
downstream targets of the Gα12 signaling axis for cancer malignancy
regulation under the control of ERα. As for in-depth mechanism, PTP4A1
was found to be directly inhibited by microRNA-141 and -200a. Gα12 and
PTP4A1 promoted epithelial-mesenchymal transition, as well as
mesenchymal to amoeboidal transition, antagonized by ERα modulations.
Conclusion and Implications The identified targets and ESR1 levels
inversely correlated in human specimens, as well as with sex-biased
survival rates of HCC patients. Collectively, ERα-dependent repression
of Gα12 and consequent changes in the Gα12 signaling may explain the
gender disparity in HCC, providing pharmacological clues for the control
of metastatic HCC.
Clinical Features and Risk Factors Analysis for Hemorrhage in Adults on ECMO
Authors: Hu Wenwen , Wang Meifang , Chen Wei , Chai Lin , Leung Elaine Lai-Han , Tang Yijun
Published: November 2020

Background: The use of extracorporeal membrane oxygenation (ECMO) to
support critically ill patients with cardiorespiratory dysfunction is
increasing over the last decades. However, hemorrhagic complications
remain occurring frequently during ECMO support, which have a
significant impact on morbidity and mortality. Methods: A retrospective
study was performed on the 60 patients, who were admitted to the Taihe
hospital in Shiyan City, Hubei Province from February 2017 to October
2020. All those were rescued with ECMO. Including 18 patients developed
hemorrhage complications and 42 patients did not. Demographic,
laboratory tests, clinical manifestations prior to ECMO were collected
to analysis the clinical features. Univariable and multivariable
logistic analysis methods were used in our study to explore the risk
factors for hemorrhage in adults on ECMO. Results: There were
significant differences between the hemorrhage group and no-hemorrhage
group in duration of ECMO support, mode of ECMO, red blood cell count,
hemoglobin, platelet count, serum creatinine. Particularly, multivariate
logistic analysis showed that the longer duration of ECMO support and
the higher activated partial thromboplastin time (APTT) prior to ECMO
were independent factors for hemorrhage in adults on ECMO. In addition,
we found that the mortality of hemorrhagic patients was higher than
no-hemorrhagic patients. Cannula site was the most common bleeding site.
Most bleeding events occurred within the first three days of ECMO
therapy. Conclusions: Clinicians should evaluate the risk of hemorrhage
based on patients’ coagulation function, underlying disease as well as
the duration of ECMO support. Especially in the first three days during
ECMO support. Attempting to wean from ECMO early whenever feasible is
also effective to reduce the occurrence of hemorrhage. Special attention
should be given on cannula site, mucosal, dermal and digestive tract to
alert hemorrhage.
Is There a Relationship between Breastfeeding Status and Life Style Changes, Eating Behaviors, Attitudes, and Orthorexia Nervosa tendencies of Mothers? A Web Based Study
Authors: EKEN Tuba FENERCIOGLU , BASER Duygu AYHAN , KASIM İsmail , SENCAN İrfan , ÖZKARA Adem
Published: November 2020

Objective: It was aimed to compare the breastfeeding status and healthy
life style changes, eating behaviors, attitudes, and orthorectic
tendencies of mothers. Materials and Methods: All volunteered mothers
who have a child between the ages of 0 and 2 were included in this
cross-sectional study. 514 individuals were included. Five parted
questionnaire and “ORTO-11” test and “Eating Attitude Test” was
used. Results: A statistically significant relationship was found
between breastfeeding status and working status and professions of
mothers. Mothers who did not breastfeed, skipped main meal more
frequently, and smoking and occasional alcohol consumption was higher.
The mean score of the participants on the ORTO-11 scale was 25.09 ±
4.80, EAT-40 scale mean score was 18.80 ± 10.42. High risk in eating
attitudes was found in 12.0% of all participants. It was observed that
mothers who did not breastfeed were mostly in high risk group in terms
of eating attitude. Conclusion: Mothers who did not breastfeed were
mostly in high risk group in terms of eating attitude compared to
breastfeeding mothers. It is of great importance that healthcare
professionals organize trainings for increasing the general level of
knowledge of mothers and provide healthy living and breastfeeding
counseling.
Arabic linked drug dataset consolidating and publishing
Authors: Lakshen Guma , Janev Valentina , Vranes Sanja
Published: November 2020

The paper examines the process of creating and publishing an Arabic Linked Drug Dataset based on open drug datasets from selected Arabic countries and discusses quality issues considered in the linked data lifecycle when establishing a semantic Data Lake in the pharmaceutical domain. Through representation of the data in an open machine-readable format, the approach provides an optimum solution for information and dissemination of data and for building specialized applications. Authors contribute to opening the drug datasets from Arabic countries, interlinking the data with diverse repositories such as DrugBank, and DBpedia, and publishing it in a standard open manner that allows further integration and building different business services on top of the integrated data. This paper showcases how drug industry can take full advantage of the emerging trends for building competitive advantages. However, as is elaborated in this paper, better understanding of the specifics of the Arabic language is needed in order to extend the usage of linked data technologies in Arabic companies.
A dual hybrid recommender system based on SCoR and the random forest
Authors: Panagiotakis Costas , Papadakis Harris , Fragopoulou Paraskevi
Published: November 2020

We propose a Dual Hybrid Recommender System based on SCoR, the Synthetic
Coordinate Recommendation system, and the Random Forest method. By combining
user ratings and user/item features, SCoR is initially employed to provide a
recommendation which is fed into the Random Forest. The two systems are
initially combined by splitting the training set into two ?equivalent? parts,
one of which is used to train SCoR while the other is used to train the
Random Forest. This initial approach does not exhibit good performance due to
reduced training. The resulted drawback is alleviated by the proposed dual
training system which, using an innovative splitting method, exploits the
entire training set for SCoR and the Random Forest, resulting to two
recommender systems that are subsequently efficiently combined. Experimental
results demonstrate the high performance of the proposed system on the
Movielens datasets.
Local laser softening of cold forming steels
Authors: Vogt S. , Weisheit A. , Schleifenbaum J. H.
Published: November 2020

The use of as-rolled cold forming steels opens new potential for lightweight construction in the automotive industry. Cold-rolled grades with a tensile strength up to 1100 MPa are on the market. However, the high strength limits the cold forming performance. A local softening in areas of high degree of deformation can be a solution to this conflict. In this work, basic studies on softening of a sheet metal were conducted. A fiber-coupled diode laser with a maximum laser power of 12 kW and a rectangular laser spot were used for laser heat treatment of the steel grade ZE 1100. It is shown that a local softening can be achieved even with short term heating. The softening is due to partly or full recrystallization of the microstructure. The tensile strength and the yield point can be reduced by about half, and the elongation at break can be increased by a factor of seven.
Foreword November 2020
Authors: JGE JGE
Published: November 2020

Foreword November 2020
Love and Fear?
Authors: Lindén Lisa
Published: November 2020

Social media are increasingly envisioned by public health authorities as a new promising arena for public engagement. Against this backdrop, this article attends to how citizens confirm, debate and resist governmental framings of health information online. By drawing upon STS and affect theory, it centers on the digital mediation of feelings on a Facebook engagement site for HPV vaccination. While the public authorities framed HPV vaccination as a matter of love and fear, a wide register of positive and negative feelings were mediated on the site. The article proposes the notion of ‘digitalised literary devices’ to analyse how mundane literary habits, such as the use of punctuation, online have been transformed to digital devices that, for instance, mediate public feelings. By conceptualizing public engagement as ‘civic intensities’, it shows how digital devices, such as digitalised literary devices, mediate and intensify public feelings of engagement.
Science Blogs as Critique — Building Public Identities in the Field of Translational Research
Authors: Hendriks Barbara , Reinhart Martin
Published: November 2020

Clinician scientists are pivotal figures in translational research. Although the discourse on translational research is favorable to clinician scientists, their role within it and their view of themselves has received little attention. In this exploratory study, we analyze the view of clinician scientists on translational research by drawing on surveillance studies and the pragmatic sociology of critique and examining the potential for critique of science blogs. From analyzing science blogs and the blogging selves they represent, we find a fundamental dilemma of being torn between the two worlds of clinic and research. Although translational research seeks to support clinician scientists, it intensifies this conflict even further. The arguments of clinician scientist-bloggers are emotionally charged with feelings of contradiction, unpredictability, and skepticism. These feelings undergird a critical agenda that shows indignation as the result of being a pivotal figure in the discourse on translational research.
"COVID-19: Network Effectiveness of Intermunicipal Self-Organized Response in Chile"
Authors: ARIAS YURISCH Karina , RETAMAL SOTO Karina , RAMOS FUENZALIDA Camila
Published: November 2020

In the context of the Covid-19 pandemic, public officials are called on to implement different strategies in order to respond effectively. One of the lessons of emergency management research is that effective response is unlikely without collaboration. Research on collaborative emergency management has focused on measuring the effectiveness of intergovernmental and intersectoral relationships, but little is known about the performance of inter-jurisdictional collaboration. This paper seeks to measure the network effectiveness of intermunicipal self-organized response to Covid-19. It uses a network analysis approach to compare planned and actual emergency management networks operating in the Santiago Metropolitan Region of Chile. Content analysis of 202 formal agreements established by municipalities in 2009-2019 was used to capture the planned network. The actual network was depicted by collecting original data through an online survey that represented the 96% of the local governments located in this Latin American city. The results show a structural gap between planned and actual networks and reveal effectiveness problems associated with the disaster preparedness phase. However, an emergent intermunicipal network has supported collaborative response to the Covid-19 pandemic. The study provides lessons for policymakers, public managers and researchers in the collaborative emergency management field.
Prototypes profiles of managerial performance
Authors: Stoian Bogdan
Published: November 2020

This study examines empirically distinct types of police managers. In an application of the typological methodology the present work investigates the performance profiles of police managers according to the similarity of their configurations. This research was exploratory and no formal hypotheses as to the number and nature of the types that will emerge were advanced. A total of 150 police officers occupying managerial positions from a variety of organizational levels participated in a combined psychological and managerial assessment program. Through inverse factor analysis the participants of this study were classified into three type categories: Aloof Technicians, Amiable Mediocres and Warmhearted Influents. The nature of these prototypical profiles was determined by examining the correlations between participantsâ€™ component loadings and scores on managerial performance, personality and mental ability variables. Implications addressing predictor-performance relations, implicit theories of performance, gender differences and relative effectiveness of each type in different situations were discussed.
Rolul moderator al încrederii organizaţionale în relaţia stresori-reacţii la stres
Authors: Pitariu Horia Dumitru , Rus Claudia Lenuța
Published: November 2020

Although the beneficial effect of trust on individual and organizational variables is empirical welldocumented,the researchers have given less attention to its moderator role in the stressorsreactionsto stress relationship. Thus, the purpose of this study is to examine the moderator roleof trust in supervisor and in organization in the relationship between eight occupational stressorsand stress reactions represented by the employees’ counterproductive work behaviors andemotions. Data were obtained from 192 employees. The results have shown that trust insupervisor negatively predicted organizational (ß= -.30, p<.01) and interpersonalcounterproductive work behavior (ß= -.24, p<.05). Trust in organization is a negative predictor ofinterpersonal counterproductive behaviors (β= -.44, p<.01) and a positive predictor of employees’positive emotions (β= .40, p<.01). The two forms of organizational trust did not moderate therelationship between the occupational stressors and the organizational counterproductive workbehavior (F(16.161)= 1.12, p>.05) and the positive emotions of employees (F(16.161) = 1.19,p>.05). Trust in supervisor moderates only the relationship between the daily hassles as anoccupational stressors and the counterproductive behavior directed to persons (β= -.36, p<.01)and trust in organization moderates the relationship between the organizational climate and theinterpersonal counterproductive behavior (β= -.27, p<.01). The results indicate that organizationaltrust can have a beneficial role on employees’ work behaviors and emotions, even in conditionsin which they perceive high levels of occupational stress.
Disease “X” changes the world. Consequences of COVID-19 pandemic for CIS member-countries
Authors: Karpovich O. G. , Litvinov V. O.
Published: November 2020

In the shortlist of blueprint priority diseases of the World Health Organization for 2018, along with the famous and dangerous diseases, there is also a disease “X”. This is a designation of a disease, which may arise due to mutations, and lead to a new epidemic. COVID-19 became such disease. The disease is characterized by a long incubation period, during which it is already contagious, and the possibility of an asymptomatic course. These factors, as well as the unpreparedness of countries, determined its success. The causative agent of the disease - SARSCoV-2 appeared in China at the end of 2019. China has taken a series of tough measures using the armed forces to defeat the epidemic. All this helped China to get out of the epidemic as soon as possible and realize the opportunities provided by the situation. In the CIS, the government of each state has chosen one of three models for resolving the issue. Kazakhstan and Kyrgyzstan went the Chinese way and took tough quarantine measures. Most states of the Commonwealth have begun to gradually introduce restrictions, which could then lead to the reintroduction of quarantine after a short break. Belarus, Tajikistan and Turkmenistan gave preference to economic development, and therefore humanitarian factors faded into the background. The COVID-19 pandemic has increased the level of health literacy of the population and the value of medical supplies. Many people became familiar with the online entertainment industry, which paved the way for new content producers. Together with the transition of people to remote work, this has increased the demand for Internet traffic. Thoughts on the automation of production and courier services arose in society. These technologies will make the transfer to a post-industrial society possible, and the country that introduced them will be able to claim the title of a major player in the international arena. The COVID-19 pandemic has opened up new possibilities for a trade war that will lead to a strengthening of the regionalization process. This may provide an incentive for the development of regional integration associations. “Belt and Road” project runs the risk of suffering trade barriers and Western attempts to get rid of Chinese dependence, which the pandemic has demonstrated. The US sanctions policy can lead to the creation of financial systems without them, which has the potential to shake the Bretton Woods system.
Characterization of Multiple-bend Optical Fiber Extensometer Design for Landslide Sensor
Authors: Costrada Aldo Novaznursyah , Deswilan Sixtinah , Kemal Badrul Mustafa , Harmadi Harmadi
Published: November 2020

Design of multiple-bend extensometer based on optical fiber as landslide sensor has been characterized. Multiple-bending characterization has been done by varying the winding number of optical fiber FD-620-10 to obtain the photodiode's effective light intensity.Â  The light intensity in the extensometer was set by varying the laser diode resistance in the range (150 â€“ 250) Î©.Â  The optimum sensitivity of 0.03984 V/cm was obtained for triple winding of optical fiber. The designed optical extensometer is able to monitor the displacement with an error of 0.59%. This result indicates that the designed extensometer is the more bending on optical fiber, the more its sensitivity and the bending loss.
Tastes in music and art in the context of self-determination of youth
Authors: Kozlovskii Vladimir Vyacheslavovich , Tkachuk Dar'ya Vladimirovna
Published: November 2020

The subject of this research is analysis of the impact of tastes in music and art upon self-determination of youth. The key problem is to identify the specificity of formation of personal preferences of youth in the process of music consumption in the context of modern cultural industries. The scale and mechanisms of the impact of music as a sociocultural factor of socialization, identification, cultural demarcation and, most importantly, social differentiation and cultural diversity are insufficiently studied. The problem of studying sociocultural capacity of tastes in music and art consists in poor perception for the sociological research on cultural determination of the practices of within and outside the intergenerational semantic (symbolic) distinction and unity within the youth environment. The goal is to search the methods for formation and representation of tastes in culture, and namely, in music and art as the elements comprising semantic and value structure of identity of a young person.  The core of the strategies for creating semantic and value structure in the course of sociocultural socialization of a person are music and art patterns that manifest in Russian youth born between 1987 and 1997 in relation to various musical genres, practices, performers and those with different tastes in music and art. Music alongside tastes in music in the context of self-determination of youth fulfill a function of worldview, behavioral and ideological reference points, an instrument for postulating new values, as well as reconsideration and of the established preferences, attitudes and patterns.
Future profession of sociologist: expectations of the university applicants
Authors: Popov Evgenii Aleksandrovich
Published: November 2020

This article considers various aspects of selecting sociological discipline by the university applicants. Based on the conducted in 2019 empirical research, the author summarizes the representations of high graduates on sociology as a scientific discipline, as well as on sociological profession. Overall, applicants became more careful in selecting sociology for their future, have an idea what is modern sociology and its development trends. This is also reflected in the official statistics, which claims that the number of applications submitted for “Sociology” has increased over the recent years. However, difficulties of such choice are revealed as well. University applicants are rather focused on acquisition of specific competences in the field of sociology, but perceive sociology as a cross-disciplinary area of knowledge. The article determines the representations of university applicants on similarities between the school course of social studies and sociology, as well as on the role of social studies in selecting sociology in the university. Assessment is given to the opinions of university applicants on the advantages of sociology in relation to other scientific disciplines; opportunities for personal and career growth in the future profession of sociologist. The author touches upon the question of formatting the image of sociologist from the perspective of university applicants. Thus, the article resolves the problem of formation of the image of future profession among university applicants that chose the academic discipline “Sociology”.  In structuring educational strategies, the universities should take into account such representations of their applicants for improving learning efficiency.