bluuebunny/crossref_metadata_2025 huggingface dataset:
Can Individual Agency Compensate for Background Disadvantage? Predicting Tertiary Educational Attainment among Males and Females
Authors: Schoon Ingrid , Cook Rose
Published: July 2020

Adolescent agency has been identified as a central aspect in the study of social mobility and status attainment. There is however still a lack of understanding of (a) how different SES dimensions influence the expression of multiple dimensions of agency; (b) the interplay of SES and adolescent agency in shaping adult outcomes; and (c) variations in these associations by gender. Focusing on educational mobility, this study adopts a multiple exposure multiple outcome approach specifying the associations between multiple SES dimensions and multiple indicators of domain-specific agency and their relative role as predictors of educational attainment, also testing for potential gender differences. The study draws on data collected for the nationally representative Longitudinal Study of Young People in England, comprising 6719 individuals born in 1989/90 (48% female; 85% first generation students; 15% ethnic minority status). The findings show that multiple SES indicators independently influence the expression of different agency dimensions, in particular regarding educational intentions and success expectations. Moreover, multiple dimensions of education-related agency are significant predictors of enrolment in university by age 20 and degree completion by age 25, after controlling for family SES, ethnicity, and prior academic attainment. The evidence points to mainly independent agency effects and provides some support for compensatory effects regarding school engagement. Although females report higher levels of education-related agency, the manifestation of agency benefits both males and females equally. The findings suggest that critical insights into social mobility processes can be gained when using more complex models that take into account multiple dimensions of SES and agency and their interactions over time.
Urban flooding in Britain: an approach to comparing ancient and contemporary flood exposure
Authors: O’Shea T. E. , Lewin J.
Published: July 2020

Using modified UK Environment Agency Flood Estimation Handbook techniques, inundation extent and likely flood hydrographs for 0.1% probability annual return periods are compared for twelve Roman town sites in the UK, both at the present day and for simulated Roman catchment conditions. Eight of the study sites appear to have suffered minimal urban flood liability as occupied in the Roman period. The exceptions were Canterbury, York, Leicester, and Chichester. It is reasonable to expect flood characteristics to have changed subsequently in response to transformations in catchment land use, urban expansion, wetland reclamation, and floodway engineering. However, modelling results suggest limited differences in flood flows attributable to such factors. Greater present-day urban damage liability essentially results from floodplain urban extension. There are also contrasts between sites: those Roman towns lying on floodplains themselves, rather than on slightly elevated terraces (Canterbury, Chichester), are dominated by groundwater regimes with attenuated flood peaks. Taken together, these results suggest some Roman awareness of the actualities of urban flood liability at the time. Site sensitivity has not been carried forward as urban expansion has flourished, especially from the nineteenth century with suburban and industrial expansion. The straightforward mapping approach here suggested should in future take account of multiple century-scale hydroclimatic changes, morphological river channel and floodplain transformations over similar time periods, and on-going improvements to inundation modelling.
Conflict in Political Liberalism: Judith Shklar’s Liberalism of Fear
Authors: Kaufmann Katharina
Published: July 2020

Realists and non-ideal theorists currently criticise Rawlsian mainstream liberalism for its inability to address injustice and political conflict, as a result of the subordination of political philosophy to moral theory (Bernard Williams), as well as an idealising and abstract methodology (Charles W. Mills). Seeing that liberalism emerged as a theory for the protection of the individual from conflict and injustice, these criticisms aim at the very core of liberalism as a theory of the political and therefore deserve close analysis. I will defend Judith N. Shklar’sliberalism of fearas an answer to these challenges. I will argue that theliberalism of fearmaintains realism’s conflictual and inherently political thrust while also integrating a perspective on injustice. I will defend the claim that in contrast to the two aforementioned criticisms, theliberalism of feardevelops its own normative standard from which political arrangements can be assessed. It does so by replacing the idealising approach to political philosophy with a non-utopian methodology, which opens a negative perspective on what is to be avoided in the political sphere, and how to detect and deal with injustice. Due to this standard, it is a liberal theory that is uniquely able to meet the realist and non-ideal challenge.
Composite-Based Path Modeling for Conditional Quantiles Prediction. An Application to Assess Health Differences at Local Level in a Well-Being Perspective
Authors: Davino Cristina , Dolce Pasquale , Taralli Stefania , Vistocco Domenico
Published: July 2020

Quantile composite-based path modeling is a recent extension to the conventional partial least squares path modeling. It estimates the effects that predictors exert on the whole conditional distributions of the outcomes involved in path models and provides a comprehensive view on the structure of the relationships among the variables. This method can also be used in a predictive way as it estimates model parameters for each quantile of interest and provides conditional quantile predictions for the manifest variables of the outcome blocks. Quantile composite-based path modeling is shown in action on real data concerning well-being indicators. Health outcomes are assessed taking into account the effects of Economic well-being and Education. In fact, to support an accurate evaluation of the regional performances, the conditions within the outcomes arise should be properly considered. Assessing health inequalities in this multidimensional perspective can highlight the unobserved heterogeneity and contribute to advances in knowledge about the dynamics producing the well-being outcomes at local level.
Ontologism in Semyon Frank
Authors: Obolevitch Teresa
Published: July 2020

Semyon Frank (1877–1950) opposed the Neo-Kantian School and admitted the real existence of the objects of cognition. He treated ontologism as essential to the entire movement of Russian religious philosophy. For Frank, one can only know about something thanks to the absolute, which exists prior to the knowing subject. Ontologism, affirming the priority of being over cognition, has a great significance not only for metaphysics and epistemology, but also for the philosophy of religion. In particular, Frank taught that the most privileged mode of cognition of God is intuition, an immediate experience of God or faith (the so-called living knowledge). Intuition is at the heart of the ontological proof, which can be found in St. Anselm, Descartes, and Frank himself. Frank dedicated a number of articles to this topic: “K istorii ontologicheskogo dokazatel’stva” (“On the History of the Ontological Proof,” 1915), “Ontologicheskoe dokazatel’stvo bytiya Boga” (“Ontological Proof of the Existence of God,” 1930), as well as texts recently discovered at the Bakhmeteff Archive, including “Dokazatel’stvo bytiya Boga” (“Proof of the Existence of God”). In this way, Russian ontologism leads to a new interpretation of the traditional ontological proof, one which acknowledges the existence of God, not on the basis of arguments resting on His definition, but on the basis of the intuitive recognition of His being.
Without actors, there is no action: How interpersonal interactions help to explain routine dynamics
Authors: Danner-Schröder Anja
Published: July 2020

In this paper, we argue that it is important to gain a better understanding onhowpeopleinteractwith each other to explain routine dynamics. Thus, we propose to focus on the interpersonal interactions of actors which is not only the fact that actors interact with each other but that the manner and quality of these interactions is important to understand routine dynamics. By drawing on social exchange theory, we propose a framework that seeks to explain routine dynamics based on different relationships between actors. Building on this framework, we provide different process models indicating how routine performing and patterning is enacted due to the respective relationship of actors. Our insights contribute to research on routine dynamics by arguing (1) that actions of patterning are dependent on the relationship of actors; (2) that trust works as an enabler for creating new patterns of actions; (3) that distrust functions as an enhancer for interrupting and dissolving patterns of actions.
Stem Cell Therapy as a Treatment for Osteogenesis Imperfecta
Authors: Götherström Cecilia , Walther-Jallow Lilian
Published: July 2020

Purpose of Review

Osteogenesis imperfecta (OI) is a chronic disease with few treatment options available. The purpose of this review is to provide an overview on treating OI with mesenchymal stem cells (MSC).

Recent Findings

Off-the-shelf MSC have a good safety profile and exhibit multilineage differentiation potential and a low immunogenic profile and are easy to manufacture. Their ability to migrate, engraft, and differentiate into bone cells, and also to act via paracrine effects on the recipient’s tissues, makes MSC candidates as a clinical therapy for OI. Due to their high osteogenic potency, fetal MSC offer an even higher therapeutic potential in OI compared with MSC derived from adult sources. Preclinical and initial clinical data support the use of MSC in treating OI.

The characteristics of MSC make them of great interest in treating OI. MSC may be safely transplanted via intravenous administration and show potential positive clinical effects.
Cyclic homology for bornological coarse spaces
Authors: Caputi Luigi
Published: July 2020

The goal of the paper is to define Hochschild and cyclic homology for bornological coarse spaces, i.e., lax symmetric monoidal functors $${{\,\mathrm{\mathcal {X}HH}\,}}_{}^G$$

X
HH

G

and $${{\,\mathrm{\mathcal {X}HC}\,}}_{}^G$$

X
HC

G

from the category $$G\mathbf {BornCoarse}$$

G
BornCoarse

of equivariant bornological coarse spaces to the cocomplete stable $$\infty $$
∞
-category $$\mathbf {Ch}_\infty $$

Ch
∞

of chain complexes reminiscent of the classical Hochschild and cyclic homology. We investigate relations to coarse algebraic K-theory $$\mathcal {X}K^G_{}$$

X

K

G

and to coarse ordinary homology $${{\,\mathrm{\mathcal {X}H}\,}}^G$$

X
H

G

by constructing a trace-like natural transformation $$\mathcal {X}K_{}^G\rightarrow {{\,\mathrm{\mathcal {X}H}\,}}^G$$

X

K

G

→

X
H

G

that factors through coarse Hochschild (and cyclic) homology. We further compare the forget-control map for $${{\,\mathrm{\mathcal {X}HH}\,}}_{}^G$$

X
HH

G

with the associated generalized assembly map.
Properties and anisotropy behaviour of a nickel base alloy material produced by robot-based wire and arc additive manufacturing
Authors: Hassel Thomas , Carstensen Torben
Published: July 2020

In order to produce three-dimensional components from metals, a wide variety of processes exist. Laser processes combined with metal powders are frequently used and developed. Restrictive factors are the machine-related small workspace, the machinery costs and the material portfolio, which place the technology in the area of high-performance components. Wire and arc additive manufacturing (WAAM), as a robust and economical welding process technology in combination with robot applications, represents an option to become more size-independent and provides variability in the range of materials. This work shows results for the robot-based WAAM of structures made from nickel alloy 617. The main focus of the investigation was the determination of the mechanical properties in the as-welded state for which static strength tests, microhardness and metallographic studies were carried out. The anisotropic material behaviour in relation to the build direction (BD) was tested. The direction-dependent strength properties of single-track welded structures are presented with samples taken and tested at 0°, 45° and 90° to the BD. The deformation behaviour was investigated by micro-tensile tests in a scanning electron microscope, whereby the formation of sliding steps on the polished surface under tensile stress was studied. The anisotropic behaviour of the WAAM structures is discussed under consideration of the microstructure and with regard to the grain size development and phase formation. The results indicate an anisotropic material behaviour in the as-welded state based of the crystallographic orientation of the material.
Protective effects of two food hydrocolloids on dental erosion: Nanomechanical properties and microtribological behavior study
Authors: Xiao Heng , Zheng Liang , Han Wei , Wu Rui , Zheng Jing , Zhou Zhongrong
Published: July 2020

In this study, the protective effects of two food hydrocolloids, Xanthan gum and Arabic gum, on dental erosion are investigated from the perspective of the nanomechanical properties and microtribological behavior of acid-eroded enamel. Enamel specimens prepared from extracted human teeth were immersed in citric acid solution (CAS), CAS with 0.03% w/v Xanthan gum and CAS with 0.03% w/v Arabic gum, respectively, for 10 min to obtain three groups of eroded specimens. The nanomechanical properties and microtribological behavior of enamel were examined using nano-indentation/scratch techniques. The results show that compared with Arabic gum, Xanthan gum inhibits enamel surface demineralization and acid permeation more effectively because of a more uniform and denser adsorption on the surface of the enamel. The impairment of the nanomechanical and microtribological properties of the enamel surface by acid erosion is mitigated more significantly by adding trace amounts of Xanthan gum than Arabic gum. In summary, adding trace food hydrocolloids reduces enamel surface demineralization and inhibits acid permeation to mitigate the influence of erosion on the mechanical and tribological properties of enamel. The adsorption state of food hydrocolloids is the determining factor in the permeability of acid agents into the enamel and plays a significant role in preventing dental erosion.
Carfilzomib-induced Thrombotic Microangiopathy: A Case Based Review
Authors: Jindal Nishant , Jandial Aditya , Jain Arihant , Lad Deepesh , Prakash Gaurav , Khadwal Alka , Nada Ritambhra , Sethi Jasmine , Ahluwalia Jasmina , Malhotra Pankaj
Published: July 2020

Carfilzomib is an irreversible proteasome inhibitor currently approved for the treatment of relapsed multiple myeloma. It has been implicated as a cause of thrombotic microangiopathy (TMA) in several case reports. The incidence, risk factors, and treatment of carfilzomib-related TMA remain unclear. Here we describe the clinical presentation and outcome of a 58-year-old man with biopsy-proven TMA that occurred following treatment with carfilzomib-based therapy. We also reviewed the published literature with regard to the incidence, risk factors, treatment options, and outcome of carfilzomib-related TMA.
Strong security starts with software development
Authors: Cope Rod
Published: July 2020

While there is – rightly – a big focus on securing software that is already deployed, the reality is that many future vulnerabilities stem from the creation of that software. Insecure applications give hackers a back door. For instance, buffer overflows and code injection attacks can lead to compromised confidentiality of data, loss of service, damage to the systems of thousands of users, even – in the case of products containing embedded software, such as medical equipment or vehicles – risk to life.

While we focus on securing software that is already deployed, the reality is that many future vulnerabilities stem from the creation of that software.

Securing development is a tough challenge due to the increasing complexity of software, the volume of code, multiple contributors, distributed teams and the pressure to deliver to tight deadlines. Plus, developers traditionally have not been focused on security. That is changing with the emergence of DevSecOps, which focuses on implementing software security practices and tools at every stage of the lifecycle, explains Rod Cope of Perforce Software.
Overcoming the security risks of remote working
Authors: Malecki Florian
Published: July 2020

The Covid-19 pandemic has transformed the way businesses operate. Around the world, governments have implemented regulation to protect people and slow the spread of the virus. This includes strict lockdown and social distancing measures that have prompted entire workforces to start working remotely.

The Covid-19 pandemic has transformed the way businesses operate. As millions of people work from the safety of their homes, we have witnessed the creation of the largestever global remote workforce.

Moving millions of employees, their computers and their data away from a secure office environment presents tremendous data security risks, ranging from simple technical glitches to full-scale ransomware attacks. The role of IT teams in business continuity has never been more important, says Florian Malecki of StorageCraft.
Ethnic Variation in Immigrants' Diets and Food Acculturation – United States 1999–2012
Authors: Gustavsen Geir Wæhler , Dong Diansheng , Nayga Rodolfo M. , Rickertsen Kyrre
Published: July 2020

Immigration has changed the United States from having a predominantly white to a more ethnically diverse population. People who move to the U.S. may initially have diets unlike native-born Americans but gradually adopt eating patterns more like them. Using NHANES data and a censored gamma regression model, this study estimated the daily consumption of major food products among groups of immigrants and the corresponding groups born in the U.S. Results show that immigrants had lower consumption of meat and higher consumption of fruits and vegetables, and immigrants’ consumption converged towards a less healthy American diet after five years in the U.S.
Race, Gender, Philanthropy and the Politics of Knowledge
Authors: Perkins Linda M.
Published: July 2020

Historically, education has often varied by curriculum, access, and stature based on location, race, gender, economic status, religion, and time period. In addition, many educational institutions and much scholarly research have been significantly impacted by private foundation support. This essay discusses the politics of knowledge as it relates to gender and race as well as the impact of philanthropy on the production of knowledge with these groups. While many aspects of these themes have changed in the past sixty years, many of them remain highly contested.
Political Engines: The Emotional Politics of Bells in Eighteenth-Century England
Authors: Tullett William
Published: July 2020

This article asks how and why bells maintained their central place in political culture between 1660 and 1832, a question that can best be approached from the perspective of histories of the emotions and senses. Such a consideration of bells allows us to extend the concept of “emotives” to encompass material culture. Often believed to “speak,” bells were fundamental to a binary emotional regime: the joy and sorrow they expressed and created were essential to perceptions of deference, community, and national feeling. But they could also be inverted and used a form of resistance. For those outside the religious or political status quo, bells could instantiate forms of emotional suffering. Tracing the “listening public” of which bells were part demonstrates the importance of the freedom to hear in the eighteenth-century public sphere. In this context, the ascription of material and emotional agency to bells was a useful rhetorical tool. Its deployment in newspaper reports of ringing, which served to encourage certain ways of listening, points to the importance of both text and sound in creating a “listening public.” But this listening public was also marked by forms of emotional suffering and exclusion that trouble the place of practices of celebration in any nascent “English” or “British” identity.
Is psychological resilience a protective factor between motivations and excessive smartphone use?
Authors: Shen Xi
Published: July 2020

Excessive smartphone use has recently become a topic of interest. Prior studies have suggested that psychological well-being variables and motivations are important predictors of excessive smartphone use. However, few have examined the internal mechanism of these factors in leading to excessive smartphone use. Based on Compensatory Internet Use theory, we investigated the moderating role of psychological resilience between two types of motivation — escapism and social interaction — and excessive smartphone use. Selecting 576 typical smartphone users, we found: (1) Escapism motivation and psychological resilience significantly correlate with excessive smartphone use, whereas social interaction motivation does not; (2) Psychological resilience moderates the relationship between both escapism and social interaction motivation and excessive smartphone use. Our study demonstrates the mechanism of different types of motivation and the protective effect of psychological resilience on excessive smartphone use. Thus, we emphasize resilience training that would help train people to be able to cope with life problems more effectively.
Effects of geographical and climatic factors on cystic echinococcosis in south-western Iran
Authors: Jamshidi A. , Haniloo A. , Fazaeli A. , Ghatee M.A.
Published: July 2020

Cystic echinococcosis (CE) is caused by the larval form ofEchinococcus granulosusthat can cause serious health and economic problems in the endemic foci. CE is globally distributed in various climatic conditions from circumpolar to tropical latitudes. Iran is an important endemic area with a spectrum of weather conditions. The aim of this study was to determine the effects of geo-climatic factors on the distribution of livestock CE in south-western Iran (SWI) in 2016 to 2018. Data of livestock CE were retrieved from veterinary organizations of four provinces of SWI. The geo-climatic factors, including mean annual temperature (MAT), minimum MAT (MinMAT), maximum MAT (MaxMAT), mean annual rainfall (MAR), elevation, mean annual evaporation (MAE), sunny hours, wind speed, mean annual humidity (MAH), slope, frost days and land cover, were analysed using geographical information systems (GIS) approaches. The statistical analysis showed that MAR, frost days, elevation, slope and semi-condensed forest land cover were positively and MAE, MAT, MaxMAT, MinMAT and salt and salinity land cover were negatively correlated with CE occurrence. MAE was shown to be a predictive factor in the stepwise linear logistic regression model. In short, the current GIS-based study found that areas with lower evaporation were the main CE risk zones, though those with lower temperature and higher rainfall, altitude and slope, especially where covered with or in close proximity of semi-condensed forest, should be prioritized for consideration by health professionals and veterinarians for conducting control programmes in SWI.
Beyond Welfare Chauvinism and Deservingness. Rationales of Belonging as a Conceptual Framework for the Politics and Governance of Migrants’ Rights
Authors: CARMEL EMMA , SOJKA BOŻENA
Published: July 2020

This article argues that the politics and governance of migrants’ rights needs to be reframed. In particular, the terms “welfare chauvinism”, and deservingness should be replaced. Using a qualitative transnational case study of policymakers in Poland and the UK, we develop an alternative approach. In fine-grained and small-scale interpretive analysis, we tease out four distinct “rationales of belonging” that mark out the terms and practices of social membership, as well as relative positions of privilege and subordination. These rationales of belonging are: temporal-territorial, ethno-cultural, labourist, and welfareist. Importantly, these rationales are knitted together by different framings of the transnational contexts, within which the politics and governance of migration and social protection are given meaning. The rationales of belonging do not exist in isolation, but, in each country, they qualify each other in ways that imply different politics and governance of migrants’ rights. Taken together, these rationales of belonging generate transnational projects of social exclusion, as well as justifications for migrant inclusion stratified by class, gender and ethnicity.
Conceptual transfer and lexical development in adjectives of space: Evidence from judgments, reaction times, and eye tracking
Authors: Wolter Brent , Yamashita Junko , Leung Chi Yui
Published: July 2020

This study investigated conceptual transfer and lexical development for spatial adjectives using participant judgments, reaction times, and eye-tracking measures. The study focused on the Japanese adjectivesemaiand its partially equivalent English translationnarrow. The study presented participants with images depicting two rooms with slight differences in height and width and asked them to identify which room was narrower. The only variation was the language in which the instructions were given: native language (L1) instructions for two L1 control groups, second language (L2) instructions for the experimental group (L1 Japanese speakers of L2 English). The results showed fundamental differences in processing between the control groups in respect to the judgments and reaction times, but not for the eye-tracking measures. Furthermore, the experimental group’s behavior indicated a conceptual understanding ofnarrowthat was in line with developments in proficiency, but also limited to the judgment and reaction time measures. Based on these findings, we conclude that (a) conceptual transfer affects processing on receptive language tasks, and (b) L2 conceptual representations come to resemble those of native speakers as learners develop their lexical knowledge. However, we also suggest that (c) although conceptualizations likely affect cognitive functions, our eye-tracking data were too crude to capture this.
Morphosyntactic adaptation in adult L2 processing: Exposure and the processing of case and tense violations
Authors: Hopp Holger
Published: July 2020

This paper investigates morphosyntactic adaptation in second language (L2) sentence processing. In a pre-/posttest control group design, two experiments with intermediate to advanced German–English learners examine whether massed exposure to informative input leads to adaptation in L2 processing in that L2 readers come to integrate inflection in real-time comprehension. Experiment 1 on case marking shows that input causing prediction error and flagging the target parse leads to nativelike integration of case in the reanalysis of garden-path sentences. Experiment 2 shows partially nativelike processing of adverbial–verb tense mismatches after exposure to target input. Adaptation was selective to the experimental versus the control group in processing, yet it did not generalize to offline, explicit performance. We conclude that morphosyntactic adaptation constitutes an implicit learning mechanism in L2 processing, and we discuss its implications for models of L2 processing and acquisition.
Testing the role of processing speed and automaticity in second language listening
Authors: Hui Bronson , Godfroid Aline
Published: July 2020

Second language (L2) listening requires efficient processing of continuing incoming information (Vandergrift & Goh, 2012). Even so, research into individual differences in L2 listening has mostly shed light on the role of linguistic knowledge measured without time pressure (e.g., Mecarty, 2000; Wang & Treffers-Daller, 2017; cf. Vafaee & Suzuki, 2020), leaving the role of processing speed and automaticity largely unexplored. To close this gap, we explored the determinants of successful listening using three processing tasks at lexical, syntactic, and propositional levels. Participants were 44 Chinese learners of English. Response accuracy afforded measures of vocabulary size, syntactic parsing skills, and formulation of propositional meaning. Reaction times and the coefficient of variation (Segalowitz & Segalowitz, 1993) afforded processing speed and automaticity measures at each level. We found a hierarchical relationship between different levels of processing, whereby lower-level, lexical effects cascade up and are mediated by propositional comprehension in accounting for listening comprehension. The results highlight the importance of considering processing accuracy and speed at different levels of the linguistic hierarchy to explain variability among L2 listeners. Different from most previous studies, we argue for a need to consider the temporal aspects of processing, along with linguistic knowledge, in modeling L2 listening.
Age, frequency, and iconicity in early sign language acquisition: Evidence from the Israeli Sign Language MacArthur–Bates Communicative Developmental Inventory
Authors: Novogrodsky Rama , Meir Natalia
Published: July 2020

The current study described the development of the MacArthur–Bates Communicative Developmental Inventory (CDI) for Israeli Sign Language (ISL) and investigated the effects of age, sign iconicity, and sign frequency on lexical acquisition of bimodal-bilingual toddlers acquiring ISL. Previous findings bring inconclusive evidence on the role of sign iconicity (the relationship between form and meaning) and sign frequency (how often a word/sign is used in the language) on the acquisition of signs. The ISL-CDI consisted of 563 video clips. Iconicity ratings from 41 sign-naïve Hebrew-speaking adults (Study 1A) and sign frequency ratings from 19 native ISL adult signers (Study 1B) were collected. ISL vocabulary was evaluated in 34 toddlers, native signers (Study 2). Results indicated significant effects of age, strong correlations between parental ISL ratings and ISL size even when age was controlled for, and strong correlations between naturalistic data and ISL-CDI scores, supporting the validity of the ISL-CDI. Moreover, the results revealed effects of iconicity, frequency, and interactions between age and the iconicity and frequency factors, suggesting that both iconicity and frequency are modulated by age. The findings contribute to the field of sign language acquisition and to our understanding of potential factors affecting human language acquisition beyond language modality.
A meta-analysis of the relationship between working memory and second language reading comprehension: Does task type matter?
Authors: Shin Jihye
Published: July 2020

Despite the increasing attention paid to the role of working memory in reading, findings and measurement of working memory have been inconsistent. The current meta-analysis aims to provide a quantitative description of the overall relationship between second language (L2) reading comprehension and working memory measured through reading span task and identify methodological features that moderate this relationship. Following a comprehensive search, 25 primary studies (23 peer-reviewed studies and 2 dissertations) were included comprising 37 unique samples (N = 2,682), all of which were coded for substantive and methodological features. The results showed that (a) there is a moderate relationship between L2 reading comprehension and working memory (r = .30), (b) reading span task features such as the scoring procedure, task language, and final word recall order moderate this relationship, and (c) the degree to which working memory’s involvement in L2 reading comprehension may vary depending on the type of reading tasks at hand. Implications are discussed in terms of conceptualization and measurement of working memory. Future directions are also offered in relation to measurement practices to encourage consistency and to improve our understanding of the link between working memory and L2 reading comprehension.
Robust Multimode Flight Framework Based on Sliding Mode Control for a Rotary UAV
Authors: Villanueva Abraham , Luque-Vega Luis F. , González-Jiménez Luis E. , Arellano-Muro Carlos A.
Published: July 2020

This work presents a multimode flight framework control scheme for a quadrotor based on the super twisting algorithm. The controller design stages for six flight control modes are presented. The stability proof for each flight mode is carried out by means of Lyapunov functions, while the stability analysis for the complete control scheme, when a transition from one flight mode to another occurs, is demonstrated using the switching nonlinear systems theory. The performance of the proposed framework is shown in a 3D simulation environment considering a forest fire detection task, which takes into account external disturbances.
Prevalence of breastfeeding and its obstacles in patients with CHD in southern Brazil
Authors: Ribas Goulart Maíra , Lima Julia , Ahlert Marcelo , Barbiero Sandra , Schneid Schuh Daniela , Pellanda Lucia
Published: July 2020

Introduction:

Breast milk is nutritionally adequate and is related to the reduction of various health problems in childhood. Its offer is widely recommended in health guidelines.

Objective:

To estimate the prevalence and obstacles to breastfeeding in patients with CHD in southern Brazil.

Methods:

Cross-sectional study of patients with CHD between 2 and 18 years of age. Patients with genetic syndromes and patients whose mothers had died were excluded from the analysis. The variables on breastfeeding in the first 2 years of life were collected through a phone call to the mothers, which was conducted by trained evaluators. Prevalence was described in proportions and the continuous variables as means and standard deviation. Bivariate analyses were evaluated using a chi-square test to measure the association between the variables and the outcome.

Results:

A total of 351 patients with CHD were analysed. There was a predominance of males (53%) and a mean age of 9.54 ± 4.52 years. Breastfeeding up to the sixth month was present in 40% of the cases.

Conclusion:

The mothers of babies with CHD face great challenges to maintain the supply of breast milk, whether inherent to the practice of breastfeeding or related to CHD.
Kein Gute-Nacht-Lied, keine Gute-Nacht-Geschichte
Authors: Rothenburg Andrea
Published: July 2020

Zusammenfassung. Kinder psychisch erkrankter Eltern sind kaum im Fokus des Versorgungssystems. Der Verein Psychiatrie in Bewegung e. V. und die Kampagne für Kinder psychiatrieerfahrener Eltern (KKPE) haben diese oft vergessene Gruppe im Blick.
Identifikation macht stark
Authors: Schädle-Deininger Hilde , Müller Christoph
Published: July 2020

Zusammenfassung. Florence Nightingale würde ein beeindruckendes Jahr erleben. 2020 jährt sich ihr Geburtstag zum 200sten, ihr Todestag zum 110ten Mal. Geboren wurde sie am 12. Mai 1820 im italienischen Florenz, in der Stadt, die ihr auch ihren Vornamen gab. Sie starb am 13. August 1910 in London.
Altitude Matters for Solar Eclipse Observations
Authors: Rehnberg Morgan
Published: July 2020

The path of a solar eclipse through Earth’s ionosphere, which can be quite different than it is at ground level, appears to explain patterns of ionized particle depletions.
Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear
Authors: Bartsch Julia Constance , Jamil Sara , Remmes Jasmin , Verma Dilip , Pape Hans-Christian
Published: July 2020

Return of previously extinguished fear memories presents a major hurdle in treatment of fear-related disorders. Neuropeptide Y receptors type 2 (Y2R) in the bed nucleus of stria terminalis (BNST) seem to play a crucial role in modulation of remote fear memories. Here, we targeted Cre-channelrhodopsin-2 to defined subregions of BNST or central amygdala (CeA) in floxed Y2R mice (Y2lox/lox) for functional deletion of Y2R. We combined fear training and behavioral studies in vivo with optogenetic-electrophysiological analysis of BNST synaptic network activity ex vivo, in order to identify regional and cellular specificities of Y2R influence. Deletion of Y2R in the ventral section of anterior BNST (BNSTav) did not affect fear acquisition, but increased conditioned fear during recall and extinction learning, and aggravated remote fear return. By contrast, deletion of Y2R in the dorsal section of anterior BNST (BNSTad) or CeA did not influence acquisition, extinction or return of fear memories. Ex vivo optogenetic-electrophysiological analysis revealed Y2R-expressing local GABAergic inhibitory networks in BNST, both within (intraregional) and in-between (inter-regional) BNST subregions. Stimulation of Y2R resulted in a presynaptically mediated reduction of GABAergic responses, which did not differ between intraregional but predominantly affected inter-regional connections from BNSTav to BNSTad. Moreover, deletion of Y2R decreased the excitation/inhibition balance in BNSTav neurons, suggesting a regulatory influence of endogenous NPY via intraregional GABAergic microcircuits. This study reveals Y2R within local GABAergic networks in BNST as key elements in facilitating extinction and reducing return of remote fear memories, suggesting a potential avenue for translational purposes.
Endogenous toxic metabolites and implications in cancer therapy
Authors: Lee Namgyu , Spears Meghan E. , Carlisle Anne E. , Kim Dohoon
Published: July 2020

It is well recognized that many metabolic enzymes play essential roles in cancer cells in producing building blocks such as nucleotides, which are required in greater amounts due to their increased proliferation. On the other hand, the significance of enzymes in preventing the accumulation of their substrates is less recognized. Here, we outline the evidence and underlying mechanisms for how many metabolites normally produced in cells are highly toxic, such as metabolites containing reactive groups (e.g., methylglyoxal, 4-hydroxynonenal, and glutaconyl-CoA), or metabolites that act as competitive analogs against other metabolites (e.g., deoxyuridine triphosphate and l-2-hydroxyglutarate). Thus, if a metabolic pathway contains a toxic intermediate, then we may be able to induce accumulation and poison a cancer cell by targeting the downstream enzyme. Furthermore, this poisoning may be cancer cell selective if this pathway is overactive in a cancer cell relative to a nontransformed cell. We describe this concept as illustrated in selenocysteine metabolism and other pathways and discuss future directions in exploiting toxic metabolites to kill cancer cells.
Exploring the upper pH limits of nitrite oxidation: diversity, ecophysiology, and adaptive traits of haloalkalitolerant Nitrospira
Authors: Daebeler Anne , Kitzinger Katharina , Koch Hanna , Herbold Craig W , Steinfeder Michaela , Schwarz Jasmin , Zechmeister Thomas , Karst Søren M , Albertsen Mads , Nielsen Per H , Wagner Michael , Daims Holger
Published: July 2020

Nitrite-oxidizing bacteria of the genus Nitrospira are key players of the biogeochemical nitrogen cycle. However, little is known about their occurrence and survival strategies in extreme pH environments. Here, we report on the discovery of physiologically versatile, haloalkalitolerant Nitrospira that drive nitrite oxidation at exceptionally high pH. Nitrospira distribution, diversity, and ecophysiology were studied in hypo- and subsaline (1.3–12.8 g salt/l), highly alkaline (pH 8.9–10.3) lakes by amplicon sequencing, metagenomics, and cultivation-based approaches. Surprisingly, not only were Nitrospira populations detected, but they were also considerably diverse with presence of members from  Nitrospira lineages I, II and IV. Furthermore, the ability of Nitrospira enrichment cultures to oxidize nitrite at neutral to highly alkaline pH of 10.5 was demonstrated. Metagenomic analysis of a newly enriched Nitrospira lineage IV species, “Candidatus Nitrospira alkalitolerans”, revealed numerous adaptive features of this organism to its extreme environment. Among them were a sodium-dependent N-type ATPase and NADH:quinone oxidoreductase next to the proton-driven forms usually found in Nitrospira. Other functions aid in pH and cation homeostasis and osmotic stress defense. “Ca. Nitrospira alkalitolerans” also possesses group 2a and 3b [NiFe] hydrogenases, suggesting it can use hydrogen as alternative energy source. These results reveal how Nitrospira cope with strongly fluctuating pH and salinity conditions and expand our knowledge of nitrogen cycling in extreme habitats.
Effects of polygenic risk for Alzheimer’s disease on rate of cognitive decline in normal aging
Authors: Kauppi Karolina , Rönnlund Michael , Nordin Adolfsson Annelie , Pudas Sara , Adolfsson Rolf
Published: July 2020

Most people’s cognitive abilities decline with age, with significant and partly genetically driven, individual differences in rate of change. Although APOE ɛ4 and genetic scores for late-onset Alzheimer’s disease (LOAD) have been related to cognitive decline during preclinical stages of dementia, there is limited knowledge concerning genetic factors implied in normal cognitive aging. In the present study, we examined three potential genetic predictors of age-related cognitive decline as follows: (1) the APOE ɛ4 allele, (2) a polygenic score for general cognitive ability (PGS-cog), and (3) a polygenic risk score for late-onset AD (PRS-LOAD). We examined up to six time points of cognitive measurements in the longitudinal population-based Betula study, covering a 25-year follow-up period. Only participants that remained alive and non-demented until the most recent dementia screening (1–3 years after the last test occasion) were included (n = 1087). Individual differences in rate of cognitive change (composite score) were predicted by the PRS-LOAD and APOE ɛ4, but not by PGS-cog. To control for the possibility that the results reflected a preclinical state of Alzheimer’s disease in some participants, we re-ran the analyses excluding cognitive data from the last test occasion to model cognitive change up-until a minimum of 6 years before potential onset of clinical Alzheimers. Strikingly, the association of PRS-LOAD, but not APOE ɛ4, with cognitive change remained. The results indicate that PRS-LOAD predicts individual difference in rate of cognitive decline in normal aging, but it remains to be determined to what extent this reflects preclinical Alzheimer’s disease brain pathophysiology and subsequent risk to develop the disease.
Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway
Authors: Yang Ruimeng , Zhan Ming , Guo Miaomiao , Yuan Hao , Wang Yiqin , Zhang Yiyue , Zhang Wenqing , Chen Saijuan , de The Hugues , Chen Zhu , Zhou Jun , Zhu Jun
Published: July 2020

Microglia are the primary immune cells in the central nervous system, which plays a vital role in neuron development and neurodegenerative diseases. Microglial precursors in peripheral hematopoietic tissues colonize the central nervous system during early embryogenesis. However, how intrinsic and extrinsic signals integrate to regulate microglia’s differentiation remains undefined. In this study, we identified the cerebral white matter hyperintensities susceptibility gene, programmed cell death protein 11 (PDCD11), as an essential factor regulating microglia differentiation. In zebrafish, pdcd11 deficiency prevents the differentiation of the precursors to mature brain microglia. Although, the inflammatory featured macrophage brain colonization is augmented. At 22 h post fertilization, the Pdcd11-positive cells on the yolk sac are distinct from macrophages and neutrophils. Mechanistically, PDCD11 exerts its physiological role by differentially regulating the functions of nuclear factor-kappa B family members, P65 and c-Rel, suppressing P65-mediated expression of inflammatory cytokines, such as tnfα, and enhancing the c-Rel-dependent appearance of tgfβ1. The present study provides novel insights in understanding microglia differentiation during zebrafish development.
A first-principle perspective on electronic nematicity in FeSe
Authors: Long Xuanyu , Zhang Shunhong , Wang Fa , Liu Zheng
Published: July 2020

Electronic nematicity is an important order in most iron-based superconductors, and FeSe represents a special example, in which nematicity disentangles from spin ordering. A first-principle description of this order remains elusive. Here, we show that by carefully searching the paramagnetic energy landscape within the density functional theory, a nematic solution stands out at either the +U or hybrid functional level with the lowest energy. The band structure and Fermi surface can be well compared with the recent experimental results. Symmetry analysis assigns the dominant order parameter to the Eu irreducible representations of the D4h point group. Distinct from the B1g Ising nematicity as widely discussed in the context of vestigial stripe antiferromagnetic order, the two-component Eu vector order features mixing of the Fe d-orbitals and inversion symmetry breaking, which lead to striking experimental consequences, e.g., missing of an electron pocket.
DC Hall coefficient of the strongly correlated Hubbard model
Authors: Wang Wen O. , Ding Jixun K. , Moritz Brian , Huang Edwin W. , Devereaux Thomas P.
Published: July 2020

The Hall coefficient is related to the effective carrier density and Fermi surface topology in non-interacting and weakly interacting systems. In strongly correlated systems, the relation between the Hall coefficient and single-particle properties is less clear. Clarifying this relation would give insight into the nature of transport in strongly correlated materials that lack well-formed quasiparticles. In this work, we investigate the DC Hall coefficient of the Hubbard model using determinant quantum Monte Carlo in conjunction with a recently developed expansion of magneto-transport coefficients in terms of thermodynamic susceptibilities. At leading order in the expansion, we observe a change of sign in the Hall coefficient as a function of temperature and interaction strength, which we relate to a change in the topology of the apparent Fermi surface. We also combine our Hall coefficient results with optical conductivity values to evaluate the Hall angle, as well as effective mobility and effective mass based on Drude theory of metals.
Evidence for topological semimetallicity in a chain-compound TaSe3
Authors: Saleheen Ahmad Ikhwan Us , Chapai Ramakanta , Xing Lingyi , Nepal Roshan , Gong Dongliang , Gui Xin , Xie Weiwei , Young David P. , Plummer E. W. , Jin Rongying
Published: July 2020

Among one-dimensional transition-metal trichalcogenides, TaSe3 is unconventional in many respects. One is its strong topological semimetallicity as predicted by first-principles calculations. We report the experimental investigations of the electronic properties of one-dimensional-like TaSe3 single crystals. While the b-axis electrical resistivity shows good metallicity with a high residual resistivity ratio greater than 100, an extremely large magnetoresistance is observed reaching ≈7 × 103% at 1.9 K for 14 T. Interestingly, the magnetoresistance follows the Kohler’s rule with nearly quadratic magnetic field dependence, consistent with the electron–hole compensation scenario as confirmed by our Hall conductivity data. Both the longitudinal and Hall conductivities show Shubnikov-de Haas oscillations with two frequencies: Fα ≈ 97 T and Fβ ≈ 186 T. Quantitative analysis indicates that Fα results from the two-dimensional-like electron band with the non-trivial Berry phase [1.1π], and Fβ from the hole band with the trivial Berry phase [0(3D) − 0.16π(2D)]. Our experimental findings are consistent with the predictions based on first-principles calculations.