bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence, Patterns, and Predictors of Venous Thromboembolic Events in Patients Undergoing Salvage Chemotherapy and Autologous Stem Cell Transplantation for Relapsed Lymphomas
Authors: Ma'koseh Mohammad , Alrwashdeh Mohammad , Abdel-Razeq Nayef , Alfar Rozan , Edaily Sarah , Bater Rayan , Zmaily Mais , Almomani Mohammad , Abdel-Razeq Hikmat
Published: June 2023

Background and objectives:

Almost 25% of patients with lymphoma may have relapse or develop refractory disease, and a majority of such patients undergo salvage chemotherapy and autologous stem cell transplantation (ASCT). Data on venous thromboembolism (VTE) in this setting are scarce. This study aimed to investigate the prevalence and factors that may increase the risk of VTE in such patients.

Patients and methods:

Adult patients who were diagnosed with lymphoma and received salvage chemotherapy and ASCT were included in the study, and the subgroup with radiologically confirmed VTE were identified. Correlations between different clinical and laboratory variables and VTE were evaluated.

Results:

A total of 216 patients (median age, 31 [range, 19–60] years) were enrolled in the study. Most patients (n = 140, 64.8%) had Hodgkin's lymphoma, while 54 (25.0%) had diffuse large B-cell lymphoma. A total of 36 (16.7%) patients had VTE, mostly as upper extremity deep vein thrombosis (n = 28, 77.8%); 18 (50%) of the cases were related to central venous catheter insertion. Thrombosis rates were higher among patients with high lactate dehydrogenase (LDH) level (29.2% vs. 5.9%, p < 0.001), those with mediastinal involvement (25.9% vs. 11.5%, p = 0.025). and those with longer hospital stay (22.3% vs.9.5%, p = 0.036). In the multivariate analysis, high LDH level (odds ratio (OR), 6.53; p < 0.001), mediastinal involvement (OR, 2.70; p = 0.005) and hospital stay >24 days (OR, 2.71; p = 0.007) were all associated with significantly higher VTE rates.

Conclusion:

Patients with relapsed lymphoma undergoing salvage chemotherapy and ASCT are at higher risk for VTE, especially in those with high LDH level, mediastinal involvement, and prolonged hospital stay. If no contraindications exist, thromboprophylaxis might be considered in these settings.
OncotypeDX Testing Does Not Benefit Patients with Estrogen and Progesterone Receptor Positive Grade 1 Breast Cancers: A TAILORx Validated Study
Authors: Sibia Udai S. , Mylander Charles , Martin Tasha , Rosman Martin , Sanders Thomas J. , Lee Young , Tafra Lorraine , Jackson Rubie S.
Published: June 2023

Background & Objectives:

We previously described a predictive AAMC model that identifies patients (grade 1, hormonepositive) who would not benefit from OncotypeDX testing. The purpose of this study was to validate the AAMC model by assessing distant recurrence-free interval (DRFI) and invasive disease-free survival (IDFS) using TAILORx clinical trial data.

Materials & Methods:

We retrospectively analyzed TAILORx trial data and categorized patients based on the AAMC model. AAMC low-risk patients are those with grade 1 and hormone-positive tumors. Kaplan–Meier curves examined DRFI and IDFS.

Results:

Of the 9195 cases, 2246 (24.4%) were identified by AAMC as low-risk. Among these AAMC low-risk patients, 55.2% had Recurrence Score (RS) 0–15, 42.3% had RS 15–25, and 2.4% had RS > 25. The 10-year DRFI did not differ for those who received adjuvant chemotherapy versus those who did not (98% vs. 96%, log-rank p = 0.46). Similarly, IDFS was comparable between those who received adjuvant chemotherapy and those that did not (86% vs. 86%, log-rank p = 0.66). Only 2.4% of AAMC low-risk patients were categorized as high-risk (RS > 25). A sensitivity analysis of this discordant group, wherein those with RS > 25 were re-classified into the no-chemotherapy group and assumed to have experienced recurrences at the rate expected without chemotherapy, did not find any difference in DRFI between those who received adjuvant chemotherapy and those who did not (log-rank p = 0.16).

Conclusion:

OncotypeDX testing does not benefit AAMC low-risk patients with hormone-positive grade 1 tumors. Based on these data, 1 in 4 TAILORx participants would not need OncotypeDX testing.
Comparative Assessment of Groundwater Suitability for Irrigation and Drinking Purposes in Agbara and Ota area of Southwestern Nigeria
Authors: Amadi, A.N.  , Olasehinde, P.I.  , Nwadioha, I.J.  , Okunlola, I. A.  , Shaibu, I.  , Nwakife, C.N.
Published: June 2023

The quality of water is measured in terms of its physical, chemical and bacteriological characteristics. Agbara and Ota area of southwestern Nigeria hosts many industries. These industries generate effluents which are discharged into the environment without any form of treatment, hence the need to ascertain the quality of water in the area for domestic and irrigation purposes. Water samples were collected and analyzed using standard laboratory techniques for physico-chemical and bacteriological parameters and the results were subjected to geostatistical analysis. The result revealed that the pH in the area is slightly acidic (5.70-6.90). The concentration of the major cations and anions falls within the permissible limit postulated by WHO. The high concentration of BOD. COD, total coliform and E.coli in water are testimonies the water in the area is poor bacteriologically and an indication of the presence of human faeces in the water. Prolong drinking of such kind of water can result to water borne diseases in the area. The high concentration of manganese in the water may be attributed to the industrial effluent from the in the area. The water index for irrigational suitability (SAR, SSP, PI, RSC, MAR and KR) suggest that the water in the area to be fairly good. The overall water quality index calculated also confirmed the poor quality status of water in the area. Good sanitary habit and proper treatment of industrial effluent before discharge into the environment is advocated. Boiling of water before use is recommended to ameliorate the effect of bacteriological contamination of the water.
Pharmacognostic and Physicochemical Analysis of Thesium viride Hill
Authors: Shehu, S.  , Iliyasu, U.
Published: June 2023

Thesium viride Hill is a sub-shrub hemiparasite belongs to the family Santalaceae. Traditionally, the powdered whole plant is use for the treatment ulcer, jaundice and splenomegaly.   This study is aimed at establishing some of the pharmacognostic features and physiochemical parameters of the powdered whole plant which can be utilize in the development of the plant monograph. The powdered whole plant material was examined by microscope and its physicochemical parameters such as; moisture content, extractive values and ash values were also determined. Microscopical examination of the powdered whole plant of T. viride identified the presence of straight walled polygonal epidermal cells, paracytic stomatal cells and unicellular covering trichomes, were found to be present. The powdered plant was found to have a moisture content (5.33%), total ash (10.33%), acid insoluble ash (3.17%), water soluble ash (4.93%), and ethanol extractive (4.87%) while water extractive (5.93%) values. Some of the pharmacognostic features and physicochemical parameters of powdered T. viride were identified and established.
Geophysical Evaluation of Groundwater Potential Using Electrical Resistivity Method in Nigerian Defence Academy, Kaduna, Nigeria
Authors: Shaibu, I.  , Udensi, E. E.
Published: June 2023

The groundwater potential of the (NDA, Kaduna) was investigated using vertical electrical sounding (VES) method. A total number of 40 vertical electrical sounding VES points were used for the investigation using Schlumberger array and data obtained were analyzed using curve matching and computer iteration techniques. The data revealed a 3-layer (A, KH and H Curve type) and 4-layer (A and H-curve type). In the 3-layer system, the apparent resistivity of the first layer ranged from 18.9 Ωm to 183.2 Ωm with a corresponding thickness of 0.7 m to 14.8 m. The second layer has apparent resistivity value ranged from 13.5 Ωm to 423.8 Ωm with a corresponding thickness in the range of 4.5 m to 14.7 m while the third layer has resistivity values ranging from 1156.4 Ωm to 3732.7 Ωm with an infinite depth. For the four (4) layered model curves, first layer’s resistivity ranged from 29.5 Ωm to 244.7 Ωm, with a corresponding thickness ranging from 0.8 m to 13.0 m. The resistivity of the second layers ranged between 25.2 Ωm to 183.4 Ωm with a corresponding thickness ranging from 8.0 m to 14.2 m. The third layer resistivity ranged from 119.4 Ωm to 586.7 Ωm with a corresponding thickness ranging from 8.1 m to 20.4 m. The forth layer has a resistivity value ranging from 1318.3 Ωm to 3240.9 Ωm with an infinite depth. An integration of both isopach and iso-resistivity maps for both the 3- layer model curves and 4- layer model curves indicates that most of the northwest parts of the study area have low apparent resistivity values and thick overburden which implies good groundwater potential while, the southern portion has a little higher resistivity values and shallow overburden, an indication of poor groundwater potential. Future boreholes in the area should reached an expected depth of 40 m to 60 m depth
Koloniale Herrschaft als Nährboden für Korruption?
Authors: Hacke Alexandra
Published: June 2023

The high prevalence of corruption in sub-Saharan Africa has been empirically proven. However, the strong regional character requires the analysis of common factors that are causal or determining for today's situation. From a historical-analytical perspective Alexandra Hacke examines to what extent practices to legitimize colonial rule, which were practiced for decades in many sub-Saharan African countries, have contributed to the emergence of current structures of political corruption. After clarifying the concepts of domination and legitimacy in Max Weber, Heinrich Popitz and Trutz von Trotha, Hacke turns to empiricism and identifies forms and legitimacies of domination.

With a preface by PD Dr Manuel Becker.
A Review of the Impact of Covid-19 Pandemic on Women Entrepreneurs
Authors: Henri Sameera , Beharry Andrisha , Mashau Pfano
Published: June 2023

This chapter provides an overview of the positive and negative impacts the Covid-19 pandemic has on women entrepreneurs in South Africa. The chapter recognises the role that women entrepreneurs play in the economy and society. The research objectives for this study were to first identify the importance of female entrepreneurs. Secondly, to determine the positive and negative impacts that Covid-19 has had on South African women entrepreneurs, and lastly, to identify the assistance provided to women entrepreneurs by the government. The methodology used to conduct research was desktop research. Information was collected from online databases in the form of articles, journals and textbooks. Only information relevant to the research objective was selected for this study. The findings revealed that female entrepreneurs play a vital role in the South African economy by creating employment opportunities, decreasing poverty and contributing to the gross domestic product (GDP). The findings revealed that lockdown restrictions implemented by the government due to Covid-19 led to many women-owned businesses not being able to operate, a decrease in sales, a drastic drop in revenue, lack of digital knowledge among women, increase in anxiety experienced by women and women entrepreneurs. The findings also suggest a lack of digital knowledge among women entrepreneurs and a lack of financial assistance provided by the government. Regulators and policymakers are challenged to invest in efforts that create an environment where female entrepreneurs are capacitated and provided with information to withstand the challenges brought by the pandemic.
Cancelled: Unified Software Design Patterns for Simulated Annealing
Authors: Goswami Rohit , S Ruhila , Goswami Amrita , Goswami Sonaly , Goswami Debabrata
Published: June 2023

Any optimization algorithm programming interface can be seen as a black-box function with additional free parameters. In this spirit, simulated annealing (SA) can be implemented in pseudo-code within the dimensions of a single slide with free parameters relating to the annealing schedule. Such an implementation, however, necessarily neglects much of the structure necessary to take advantage of advances in computing resources and algorithmic breakthroughs. Simulated annealing is often introduced in myriad disciplines, from discrete examples like the Traveling Salesman Problem (TSP) to molecular cluster potential energy exploration or even explorations of a protein’s configurational space. Theoretical guarantees also demand a stricter structure in terms of statistical quantities, which cannot simply be left to the user. We will introduce several standard paradigms and demonstrate how these can be “lifted” into a unified framework using object-oriented programming in Python. We demonstrate how clean, interoperable, reproducible programming libraries can be used to access and rapidly iterate on variants of Simulated Annealing in a manner which can be extended to serve as a best practices blueprint or design pattern for a data-driven optimization library.
Acute Effects of Reduced-Exertion High-Intensity Interval Training (REHIT) on Arterial Stiffness in Normal-Weight and Overweight/Obese Individuals
Authors: Songsorn Preeyaphorn , Khantakas Pannita , Penpitakbut Phornchanok , Ratsameamonrat Runyapon , Patavee Patcharaphorn
Published: June 2023

Background: Increased arterial stiffness (AS) following exercise may be associated with acute cardiovascular events. High-intensity exercise may play an important role in an acute increase in AS after exercise. Objectives: This study aimed to examine the acute effect of reduced-exertion high-intensity interval training exercise (REHIT) on AS among individuals with insufficient physical activity compared with that among normal-weight and overweight/obese individuals. Methods: Twenty-four young adults with low physical activity were divided into the normal-weight group (n = 12, age 21.9 ± 0.8 years, body mass index (BMI) 20.97 ± 1.21 kg/m2) and the overweight/obese group (n = 12, age 21.9 ± 0.5 years, BMI 27.06 ± 5.24 kg/m2). All participants performed REHIT (20 s × 2 all-out sprints on a cycle ergometer for 10 min). Brachial-ankle pulse wave velocity (baPWV), heart rate (HR), blood pressure (BP), rating of perceived exertion (RPE), and affect responses were assessed before and after exercise for 1, 30, and 60 min. Results: Following REHIT, the HR increased, and baPWV decreased, which then returned to baseline at 60 min in both groups. However, there was no significant difference in the HR and baPWV between the normal-weight and overweight/obese groups (P > 0.05). The RPE increased significantly in both groups (P < 0.05). There was no significant change in the affect responses following REHIT (P > 0.05) in both groups. Conclusions: Our main finding was that baPWV did not increase after REHIT in either the normal-weight or overweight/obese groups. This suggests that REHIT can safely be done in physically inactive individuals, both in normal-weight and overweight/obese groups, with no adverse increase in arterial stiffness.
Žalobní typy ve správním soudnictví – Aktuální otázky
Authors: Svoboda Tomáš , Halml František , Hejč David , Hrubešová Sára , Skládalová Denisa
Published: June 2023

The aim of the monograph is to identify some “current issues” concerning the system of types of action in the Code of Administrative Justice. The legislation regulating the basic aspects of the Czech Administrative Justice system enters its twentieth year of effectiveness in 2022. However, during this time some challenges have emerged, which the monograph seeks to discuss and analyze.
Penanaman Karakter Disiplin dalam Kegiatan Apel Pagi di SD Negeri Panggung Lor
Authors: Miladia Nur Istighfaroh  , Ferina Agustini  , Muhammad Prayito  , Trinil Wigati
Published: June 2023

ABSTRAK: Penanaman pendidikan karakter disiplin pada peserta didik tidak hanya  dilakukan dengan cara pengintegrasian  karakter ke dalam mata pelajaran saja akan tetapi dilakukan pula melalui pembiasaan salah satunya pembiasaan apel pagi. Penelitian ini bertujuan untuk mendeskripsikan penanaman karakter disiplin dalam kegiatan apel pagi di SD Negeri Panggung Lor. Penelitian ini menggunakan pendekatan kualitatif yang dilaksanakan di SD Negeri Panggung Lor dengan subjek guru dan siswa. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah wawancara, observasi dan dokumentasi. Dari data yang terkumpul kemudian diolah untuk disajikan sebagai data yang utuh. Teknik pemeriksaan keabsahan data yang digunakan adalah teknik triangulasi. Hasil penelitian menunjukkan penanaman karakter disiplin dalam kegiatan apel pagi di SD Negeri Panggung Lor diantaranya siswa dapat menaati peraturan sekolah dengan berangkat lebih awal dan memakai seragam lengkap. Siswa dapat lebih teratur saat baris berbaris di lapangan untuk melaksanakan apel pagi. Budaya antri saat berjalan menuju lapangan ini selain menumbuhkan karakter disiplin juga menumbuhkan kesabaran, solidaritas, sikap menghargai dan tenggang rasa terhadap orang lain.
Kata kunci : Pendidikan Karakter, Karakter disiplin, Kegiatan Apel Pagi
Resolusi Konflik Islam Arus Utama dan Kelompok Ahmadiyah di Desa Manis Lor Studi Atas Rekognisi Axel Honneth
Authors: Dyah Aprilia , M.Pahlevi Rajasyah P.C.P  , Nur Faridah  , Fina Dwi Amalia  , Aditya Muhammad Noor
Published: June 2023

Penelitian ini memiliki tujuan untuk konflik masyarakat Islam Ahmadiyah berdasarkan teori Axel Honneth serta respon masyarakat di Desa Manis Lor terhadap aliran Ahmadiyah yang berada di negara Indonesia. Jenis penelitian yang dipergunakan dalam menunjang penelitian ini yaitu menggunakan metode studi literatur. Sumber data yang digunakan dalam menunjang  penelitian ini yaitu berasal dari jurnal terdahulu yang membahas penelitian terkait mengenai Resolusi Islam Arus Utama dan Kelompok Ahmadiyah. Teknik atau cara pengumpulan data yang digunakan dengan cara studi kepustakaan jurnal terdahulu yang terkait. Berdasarkan studi literatur yang telah dilakukan diperoleh hasil yang menunjukkan Islam Ahmadiyah selaras atau sejalan dengan teori yang diungkapkan oleh Axel Honneth serta respon masyarakat yang berbeda beda terhadap Islam Ahmadiyah namun, sebagian besar respon masyarakat yaitu menolak Islam Ahmadiyah. Hal tersebut dikarenakan teori Axel Honneth mengenai pengakuan sama dengan yang dilakukan Mirza Ghulam Ahmad yang mengakui dirinya sebagai utusan Tuhan. Selain itu juga respon masyarakat yang menolak Islam Ahmadiyah dikarenakan ajaran Islam Ahmadiyah tidak sejalan dengan ajaran pada Al Quran. Kesimpulan yang dapat disimpulkan dari penelitian ini adalah pengakuan Mirza Ghulam Ahmad sebagai utusan Tuhan selaras dengan teori yang dikemukakan oleh Axel Honneth mengenai pengakuan, namun pengakuan Mirza Ghulam Ahmad mendapat respon negatif dari masyarakat sekitar dikarenakan tidak sejalan dengan ajaran kitab suci Al Quran.
 
Kata kunci : ahmadiyah, konflik, rekognisi, resolusi
KH. Abdurrahman Wahid: Telaah Pemikiran Dan Relevansinya Pada Pendidikan Multikultural di Indonesia
Authors: Lathif Wardil , Alimul Muniroh
Published: June 2023

Multicultural Education is an alternative means of conflict resolution, students are expected not to leave their cultural roots. Multicultural education is very relevant to use for existing democracy as it is today ic accordance with KH. Abdurrahman Wahid’s thoughts. Abdurrahman Wahid who supports democratic values. This study aims to explore KH. Abdurrahman Wahid’s thought and it relevance to Multicultural Education in Indonesia. Design of study is library research (library research). Data of the study were based on works of KH. Abdurrahman Wahid. The result of study on KH. Abdurrahman Wahid thought, showed that the differences in religion, culture, and ethnicity to be addressed wisely; every group ini society has an equal position; Islam recognizes the existence of differences in religion; Plurality in the world is a reality. The relevance of KH. Abdurrahman Wahid with Multicultural Education in Indonesia, namely: showed that the differences in religion, culture, and ethnicity to be addressed wisely relevant to the system, process, evaluation, goals of multicultural education; Every group ini society has an equal position is relevant to the evaluation of multicultural education; Islam recognizes the existence of differences in religion relevant to the goals of multicultural education; Plurality in the world is a reality relevant to the multicultural education system.
Mobile-based business-to-business platform for the pharmaceutical industry in Tanzania
Authors:   , Lyimo Martine
Published: June 2023

The right to the uppermost attainable standard of health is a fundamental human right. In everyday life, mobile phones have become essential devices for most people in both developed and developing countries. Paper-based ordering of medicines in the pharmaceutical industry is time consuming and can enhance the spread of diseases such as COVID-19. Electronic ordering and stock management can solve these challenges, but while it has been widely adopted in developed countries, it remains underused in Tanzania. This study aimed to develop a mobile application (DawaFasta) and web application which links wholesale and retail pharmacies in Tanzania, to support electronic ordering and stock management. System and user requirements were collected through questionnaires, interviews and observations from 105 wholesale and retail pharmacies in Arusha, Dar es salaam and Kilimanjaro regions of Tanzania. The developed applications were evaluated for acceptability and usability by 9 wholesale and 15 retail pharmacy personnel to assess serviceability and usefulness. The results show that 96% found it very useful. The main reason is to bridge the gap between wholesale and retail pharmacies and provide easy access to medications. The 4% were not sure because they were unable to distinguish between legitimate and illegitimate online pharmacies. The application was assessed as having good usability for online pharmacy business purposes by wholesale and retail pharmacies. This application would need further development in order to raise awareness and add more features
Internet of things based system for environmental conditions monitoring in poultry house: A case of Tanzania
Authors:   , Lufyagila Beston
Published: June 2023

Poultry health is imperative for the continued growth of poultry and increased production. Environmental conditions such as temperature, humidity, and Ammonia gas impact the health of the poultry; whereby, they can affect the respiratory system and eventually cause death. In Tanzania, most farmers use charcoal and kerosene stoves to control these parameters as they have limited access to economical, secure, and user-friendly poultry house monitoring systems. However, such traditional methods are not environmentally friendly, unreliable, difficult to manage, and inaccurate. In addition to that, many smart poultry monitoring platforms proposed by previous studies are not centralized, thus making the system being not scalable and costly. For example a farmer with three distributed coops needs three monitoring platforms to monitor the coops while only single platform could suffice. Therefore, this study proposes an Internet of Things (IoT) based system for environmental conditions monitoring in the poultry house to address the aforementioned challenges. The survey was conducted in Arusha and Kilimanjaro regions respectively to determine the strength and weakness of the traditional methods used by poultry farmers, perception towards the proposed system and identify the requirements needed to develop the proposed an IoT based system. The study used Jupyter Notebook powered by Anaconda package manager and the Python language for data analysis. Based on the requirements gathered from the survey, the prototype that is divided into two four parts; sensing, aggregation, transmission and monitoring part was developed, where the hardware components were selected based on the cost, open source, availability in local market, Quality of Service (QoS), throughput and latency criteria. The developed prototype was deployed in the field to verify and validate its performance. This activity was done in seven days consecutively and the results indicated that the system would save both small scale and large scale farmers in terms of time and labor costs as Farmer can monitor and control the poultry house conditions securely, reliably, and remotely. The study also proposes an algorithm to allow the system to work online, and offline (i.e., synchronizing with the cloud server when the Internet access is available).
Sanger sequence automatic analysis tool development
Authors:   , Mero Victor
Published: June 2023

The Sanger sequencing technique still remains the cornerstone methods for the Deoxyribonucleic acid (DNA) sequencing. This is due to its high accuracy in targeting smaller genomic regions in a large number of samples, sequencing of variable regions and validating results of other DNA sequencing platforms such as those from next-generation sequencing studies. The analysis of Sanger sequence DNA data is computationally intensive requiring efficient and high computational power software tools. The most preferred tools are the proprietary licensed tools since they offer user-friendly interface and they offer more DNA analysis functionalities. However, the affordability of the tools may be limited especially for individual researchers or students due to their expensive licenses. Nevertheless, free and open source licensed tools are available and but are not user-friendly, have steep learning curve since some lack graphical user interface, operating system platform dependent and have limited functionalities. This study presents a Sanger Sequence Automatic Analysis Tool (SSAAT), a software tool designed and implemented as a web application that provides a user-friendly graphical interface such as those provided in proprietary tools. The tool has abilities to extract raw data from sequence AB1 files, make base-calls, plot chromatogram, polymorphism detection, sequence alignment and report generation. Furthermore, the tool is free and open source that can be easily accessed online through standard web browser applications. With the above-mentioned features, SSAAT can be used by molecular biologist as an alternative to proprietary tools and get comparable experience and DNA sequence analysis results
Modeling the effect of binding kinetics in spatial drug distribution in the brain
Authors:   , Kashaju Nelson
Published: June 2023

Key factors in the process of drug delivery in the human brain are blood-brain barrier, drug dis tribution and drug binding kinetics. Since human brain is entirely unavailable for experimenta tion, mathematical models have become vital for improved visualization of how each of the key factors affects the delivery of drugs in the the human brain. In this study, a 3-dimensional math ematical model that incorporates drug transport across the blood-brain barrier, binding kinetics and drug distribution within the brain extracellular fluid with a bidirectional bulk flow of the brain extracellular fluid was developed and simulated. The model was developed assuming a cube volume of a brain unit that is a union of the blood-brain barrier, brain extracellular fluid and the blood plasma sub-domains. The model includes a set of partial differential equations and boundary conditions that characterize the processes in the specified sub-domains. To determine the effect of drug binding kinetics, the model equations together with their prescribed boundary conditions were discretized by employing the finite difference method implicit schemes and the model was analysed and simulated using MATLAB coding. Effects of drug binding kinetics were investigated by varying the binding parameter values for both specific and non-specific binding sites. All variations of binding parameter values were discussed and the results show the improved visualization of the effect of binding kinetics in drug distribution within the brain. For more realistic visualization, it was suggested to integrate more brain components that make up the large volume of the brain tissue
Corruption dynamics in Tanzania: Modeling the effects of control strategies
Authors:   , Danford Oscar
Published: June 2023

Corruption can be defined generally as taking bribes, forcing out benefit, receiving money or gifts as favour in exchange for doing one’s job. Worldwide corruption is considered a problem that affects many countries in the world currently. Individuals loses their rights, lower community confidence in public authorities, termination of employment, absence of peace and security and misallocation of resources. Despite various measures which have been taken by different countries to control corruption, the problem still persists. The negative impacts of corruption are well known; however, little has been done on mathematical modelling on corruption, particularly the inclusion of mass education and religious teaching as a strategy for controlling corruption spread. In this study, the mathematical model for the dynamics of corruption in the absence and presence of these control measures are presented and analysed to determine which parameter are very sensitive to the spread of corruption and how will these control strategies help to reduce corruption. Most parameters used in this work are from different literature and some were assumed. The next generation matrix method is used to compute the basic and effective reproduction number which used to study the corruption dynamics. Sensitivity analysis results shows that, parameters of mass education and religious teaching are the most sensitive to the control of corruption. Also, stability analysis for equilibrium states by linearization, Lyapunov function and use of the Lassalle’s invariance principle was derived and the results shows that the corruption free equilibrium is locally and globally asymptotically stable when 𝑅0 < 1 and endemic equilibrium is globally asymptotically stable when 𝑅0 > 1. The model was simulated by using Runge-Kutta 4 th order in MATLAB and the results depict that when mass education  and religious teaching  are combined together as a control measures, corruption within the country is successfully controlled in a short period of time. The study recommends to invest more in provision of mass education to the citizens through creating general awareness to all and including it in education curriculum from pre-primary to university as well as to use religious leaders to teach their followers seriously about the impact of corruption. The numerical simulation results agreed with the analytical results.
RFID based warehouse management system. a case study of rok industries
Authors:   , Ngaboyimbere Fabien
Published: June 2023

In the supply chain and logistics industry, the precision of the data assets inventory plays a crucial role in warehouse activities. The operations like storage locations arrangement, inventory management, and maintaining the flow of incoming and outcoming goods lead to the success of the warehouse. Nowadays, most people prefer online shopping all over the world because it is faster than local trade. Thus, there's massive information in the supply chain and logistics sector to explore in order to improve operations of the warehouse such as receiving, ordering, shipping, storage assignment to facilitate the automation in the warehouse. As result, this research is proposed to improve warehouse activities. The RFID-based warehouse management system automates storage and inventory management without any human intervention. In order to accomplish the objectives of the study, a software program was developed with sets of rules, and an algorithm to optimize the inventory operations with the help of RFID technology. The predefined rules help in giving priorities to some of the selected products to store and retrieve in the indicated location. The long-range RFID reader is used in this project. The reader is attached to the entrance of the gate of the warehouse to facilitate the reading of incoming goods. Once the goods arrive in the warehouse, the storage location function will assign to each one the storage location and update status in the database. A handheld reader attached to the forklift facilitates inventory management and communicates with the application via a wireless network and finally store data in the database for future use. After developing this system, a test was conducted for testing the feasibility and applicability of the system. The output showed that the inventory management operation was made strides, and the correctness of inventory location increased from 72.8% to 99%. The cycle time moreover decreases from 60 minutes to 20 minutes which is down to 28.79%.
A passenger security system for mass transit electric buses: a case study of the Kayoola EVS bus
Authors:   , Koojo Ivan
Published: June 2023

Kiira Motors Corporation (KMC), a state-owned enterprise was established in 2011 to champion the development of the Ugandan automotive value chain for job and wealth creation. Kiira Motors Corporation has developed several electric vehicles on the African continent since 2011, key among them is the company’s market entry product; the Kayoola EVS, a fully electric, low floor city bus with a passenger capacity of ninety-one. Through the passenger security system, KMC sees to attain its core value of customer satisfaction and solve issues like rampant insecurity of passengers and their property which are not alien occurrences on commuter taxis and buses in many African cities. The system further seeks to address, the spread of contagious diseases like COVID-19 and its risks to bus passengers. And easen difficult, time consuming tasks like passenger counting, measuring/recording temperatures, and collecting contact information. The system data and requirements elicitation was conducted using techniques like surveys, interviews, observation, literature review, webinars and desk research. These qualitative and quantitative approaches were adopted to offer insight on passenger security and mass public transport operations. A prototype of a comprehensive system comprising software and hardware components like cameras, web and mobile applications, was developed and its units’ functionality tested in an office environment. The developed system denotes potential to ensure security on the Kayoola EVS bus. It also implies averting spread of contagious diseases, timely capture of contact tracing records plus easier management and accountability for the numbers of passengers on buses.
Soil data collection using wireless sensor networks and offsite visualization: case study of the innovative solutions for digital agriculture project in Kenya
Authors:   , Mbandi Josephine
Published: June 2023

The applications of Wireless Sensor Networks (WSN) and Internet of Everything (IoE) has changed how we obtain and consume information. Traditional farming has come a long way in accepting scientific methods to improve production. Smart Agriculture is one of the ways technology has greatly contributed to maximized crop production. Centrally placed labs and mobile soil labs have played a key role in this improved way of farming. Soil samples are collected from farms and analyzed to provide data to farmers, extension workers, and policymakers. This process takes time and is costly to implement. In addition, the definition of trends is difficult as replication of sampling requires more funding. This study proposes to connect end devices in an IoE system bringing in real-time data and at low-cost and also providing local data at local stations. The system is built incrementally to have a minimum viable product (MVP) using a combination of Agile and Waterfall methods of development. The system presents a pilot remote sensor module in a WSN using a Raspberry Pi minicomputer as an end node and three sensors collecting information on soil humidity and temperature, air humidity and temperature and soil pH values in real-time. A cloud-based data analysis and visualization are used. The system supports the ongoing work by soil labs by collecting information that is close to real-time. The study brings on board real-time data relaying of farm parameters that make it easier for small scale farm owners, extension officers, soil labs and other stakeholders to make instant informed decisions.
An oboe concerto in Lund formed from three operatic arias by Antonio Lotti
Authors: Talbot Michael
Published: June 2023

Manuscript parts for an anonymous oboe concerto in G minor shelfmarked L:10 are found in the Wenster collection at the University Library in Lund. The concerto has the peculiarity that each of its three movements is cast in da capo aria form. It turns out that the movements have been taken from arias in two operas by Antonio Lotti, Giove in Argo (1717) and Ascanio (1718), written for performance in Dresden. The manner of conversion from aria to concerto movement is very simple, entailing the reassignment of the vocal line to oboe, lightening of the string accompaniment in some solo passages and otherwise only minimal recomposition. Great care has been taken to match the movements to one another to create an instrumental pasticcio. The evidence that Lotti himself undertook the conversion is very strong, since his only other known concerto (for oboe d’amore, in A major) likewise uses da capo aria form for each movement, something previously not encountered in the genre. The identity of the performer for whom these concertos were written is considered, a likely candidate being the Dresden oboist Johann Christian Richter, whom Lotti had probably first encountered in Venice in 1716–1717.
Optimalisasi Kesehatan Jiwa melalui Pelatihan Kader Kesehatan pada Masa Pandemi Covid-19 di Kelurahan Tobek Gadang, Kota Pekanbaru
Authors: Zukhra Ririn Muthia , Nauli Fathra Annis , Elita Veny , Jumaini Jumaini
Published: June 2023

Corona virus disease 19 merupakan penyakit infeksi pada sistem saluran pernapasan. Kasusnya Covid-19 terus meningkat dan telah menyebar hampir keseluruh belahan dunia termasuk Indonesia. Dampak yang ditimbulkan tidak hanya masalah kesehatan fisik, namun juga masalah psikologis atau mental. Dampak psikologis yang dirasakan oleh masyarakat di Kelurahan Tobek Godang adalah stres dan cemas akibat pembatasan social, takut tertular, stress dalam membimbing anak belajar di rumah bahkan  mengalami masalah finansial. Pelatihan ini bertujuan untuk mengetahui gambaran kesehatan mental, melakukan pendidikan kesehatan berupa edukasi dan pelatihan penanganan stres seperti teknik napas dalam, relaksasi otot progresif, dan hipnotis lima jari. Kegiatan ini dilakukan di Kelurahan Tobek Godang Kota Pekanbaru. Khalayak sasaran adalah kader kesehatan yang berjumlah 20 orang. Rata-rata pengetahuan sebelum diberikan pelatihan diperoleh 63 poin, sedangkan setelah diberikan pelatihan meningkat menjadi 90.5 poin. Peningkatan pengetahuan yang cukup signifikan sebesar 27,5 % dan kader juga mampu melakukan berbagai strategi penanganan stres. Setelah dilakukan edukasi dan pelatihan, kader kesehatan diharapkan dapat menerapkan strategi penanganan masalah kesehatan jiwa kepada masyarakat sekitar yang terdampak pandemi Covid-19.
Pelatihan Kosakata Bahasa Inggris Mengenai Cuci Tangan 6 Langkah Sebagai Perilaku Hidup Bersih dan Sehat di SDN 200120 Padangsidempuan
Authors: Siregar Hidayanti Rohimah Nurdin , Hasibuan Khairunnisah , Handayani Fitri Rahma
Published: June 2023

Pelatihan Kosakata Bahasa Inggris di Sekolah Dasar merupakan salah satu program pengabdian masyarakat. Tujuan dari pengabdian masyarakat mengenai pelatihan kosakata Bahasa Inggris tentang perilaku hidup bersih dan sehat (PHBS) cuci tangan 6 langkah adalah agar siswa-siswa di sekolah dasar memiliki pengetahuan tentang kosakata bahasa inggris berkaitan dengan cuci tangan 6 langkah dan mampu mengucapkannya dengan benar. Kegiatan pengabdian dilakukan dalam tiga tahapan yaitu persiapan, pelaksanaan dan evaluasi. Lokasi Pengabdian Masyarakat ini dilaksanakan di SD N. 200120 Losung Batu Kota Padangsidempuan pada siswa kelas 6 yang berjumlah 30 orang. Kegiatan yang dilakukan selama pelatihan adalah pemaparan materi Bahasa Inggris mengenai cuci tangan 6 langkah dengan menggunakan media pembelajaran video. Hasil kegiatan pengabdian masyarakat menunjukan bahwa anak-anak sangat senang dan tertarik dengan program pelatihan kosakata Bahasa Inggris dan mereka dapat mengucapkan kata-kata Bahasa Inggris dengan baik. Dengan demikian pelatihan penggunaan kosakata Bahasa Inggris bagi siswa sekolah dasar dapat meningkatkan pengetahuan mereka akan Bahasa Inggris.
Pengelolaan Air Bersih Siap Guna Dengan Metode Filtrasi Pada Pondok Pesantren X Daerah Bantul
Authors: Julaikah Julaikah , Astuti Bariana Widitia
Published: June 2023

Air bersih sebagai kebutuhan penting manusia, pada banyak tempat mengalami permasalahan mulai dari persediaan sampai dengan kualitas yang tidak sesuai dengan baku mutu sehingga menimbulkan berbagai permasalahan, khususnya dalam bidang kesehatan. Pondok pesantren X yang terletak pada daerah bantul merupakan salah satu tempat yang memiliki permasalahan kualitas baku mutu air bersihnya. Hal ini disampaikan oleh beberapa santri yang mengalami keluhan gatal setelah menggunakan air sumur pondok untuk keperluan hygiene dan sanitasi sehari-hari. Pembuatan alat pengolahan air baku sederhana menggunakan sistem filtrasi diharapkan dapat membantu masyarakat untuk mengolah air kotor menjadi air baku dalam skala kebutuhan rumah tangga. Alat tersebut mudah dioperasikan, dengan bahan yang murah dan mudah didapatkan, serta dapat dipindahkan karena memiliki dimensi yang tidak terlalu besar. Kegiatan ini bertujuan untuk Meningkatkan kualitas air bersih yang di lingkungan pondok pesantren X sesuai dengan baku mutu air bersih serta sebagai upaya mengurangi keluhan gatal pada santri. Kegiatan ini dilaksanakan di pondok pesantren X dengan sasaran kegiatan air sumur sumber air bersih pondok X yang kemudian berikan tindakan filtrasi melalui pembuatan alat pengolahan air dengan system filtrasi dan penilaian hasil kegiatan menggunakan pemeriksaan fisik air dan konfirmasi keluhan santri pada pengelola pondok. Pembuatan alat filter air bersih terdiri dari bahan pipa paralon yang diisi dengan tiga jenis media yang berfungsi untuk menyaring dan menyerap kontaminan yang terkandung dalam air. Air yang diolah menggunakan filter akan melewati ketiga media yang terdiri dari batu zeolit, pasir silika dan arang aktif. Hasil pemeriksaan fisik menunjukkan air yang melalui proses filtrasi lebih jernih dan tanpa bau, selain itu juga pengelola pondok mengkonfirmasi bahwa setelah penggunaan alat filtrasi tidak ada keluhan gatal dari santri pengguna air.
The Efficiency of Providing Animal Protein from Fish as Supplementary Feeding for Toddlers with Stunting
Authors: Nugroho Muhammad Ridho , Yansyah Dedi , Rhedo Umarsyah , Armeidi Erwin , Erawani Feri Herita
Published: June 2023

Given its many benefits over other animal products as a source of protein, salmon is a very suitable source of animal protein to help initiatives that aim to enhance community nutrition and combat stunting. To keep Indonesia from losing its golden generation in the future, stunting must be treated appropriately. The aim of this study was to evaluate the impact of supplemental fish-based diet on the nutritional status of stunting toddlers. The sample in this study consisted of 26 stunted toddlers receiving fish-based supplementary feeding (PMT) for 90 days from September to December 2023 at the Simpang Periuk Health Center work area. An experimental design with a pre- and post-test strategy without control was used in this study's methodology. By contrasting the nutritional status of toddlers before and after the intervention, a paired sample test was utilized as the statistical analysis. December 2022 saw the completion of this study. The findings indicated that there were significant differences in the nutritional status of toddlers before and after receiving the intervention, with a p-value of 0.000 (.05) indicating that this was the case. It can therefore be deduced that providing fish-based PMT interventions for 90 days can improve toddlers' nutritional status, lowering the rate of stunting in the target toddlers.
Tellurium resources in New Mexico
Authors: McLemore V.T.
Published: June 2023

Tellurium (Te) is one of the least abundant elements in the crust and tends to form minerals associated with gold, silver, bismuth, copper, lead, and zinc sulfide deposits. There are no primary tellurium mines in the world; most tellurium production comes from the anode slimes generated in metal refining, primarily from copper porphyry deposits. Tellurium is used as an alloying agent in iron and steel, as catalysts, and in the chemical industry. However, future demand and production could increase because tellurium is progressively used in thin film cadmium-tellurium solar panels and some electronic devices. In New Mexico, anomalous amounts of tellurium are found associated with porphyry copper deposits, as well as with gold-silver vein deposits, but were not considered important exploration targets in the past. The only tellurium production from New Mexico has been from the Lone Pine deposit (Wilcox district) in the Mogollon Mountains, where approximately 5 tons of tellurium ore were produced. Gold-tellurides are found with gold, silver, pyrite, and fluorite in fracture-filling veins in rhyolite at Lone Pine, with reported assays as much as 5,000 ppm Te. Tellurium-bearing deposits also are found in the Organ Mountains, Sylvanite, Tierra Blanca, Grandview Canyon, and Hillsboro districts. Additional detailed sampling and geologic mapping are required of the New Mexico deposits to fully understand the mineralogy and economic potential of tellurium.
The impacts of tourism on life quality in the community: Case of Cu Chi, Ho Chi Minh City
Authors: Tran Huu Ai , Huynh Anh Nga
Published: June 2023

This research examines the impact of tourism and local residents support for development of tourism destination in the Cu Chi, Hochiminh City. The study conducts a survey by using a formal questionnaire with participation of 291 residents who are living in Cu Chi, five research hypotheses were proposed. The findings show that the economic impacts of tourism were most favorably behavioral control and socio-cultural factor. Tourism service generates great pressure on local resources, impact on energy consumption, food, and other raw materials requirements that are in shortage and unavailability. Besides that, tourism causes pollution and exhausts environment as any other industries. For long-term strategy of tourist development, tourism must incorporate the principles and practices of sustainable consumption.
Dramatizing vocabulary teaching in classes of young learners
Authors: Do Thi Bich Thuy
Published: June 2023

Learning and memorizing vocabulary is very important in language learning, especially for young learners. There are a lot of methods that help learners to approach and get acquainted with effectively. One of the feasible methods is to dramatize vocabulary teaching in classes of young learners. This method not only helps learners to practice and memorize vocabulary longer because of their creativity through the use of language while performing drama, but it also gives them an interest in learning as they have the opportunity to interact directly in the natural role play.