bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Different Levels of Spirogyra Incorporated Diet on Bio Growth Performance, Digestive Enzyme Activity and Haematology of Etroplus suratensis
Authors: Kumar Salkapuram Sandeep , Selvaraj S. , Antony Cheryl , Aruna S. , Ruby P.
Published: January 2025

Background: Etroplus suratensis is omnivorous feeder, but mainly feeds on filamentous algae especially Spirogyra. The preference of pearlspot towards Spirogyra as an important food item, made us utilize the Spirogyra as an ingredient in the feed of pearlspot at different levels to evaluate its impact on growth and other parameters. Methods: The experiment was conducted to evaluate the effect of Spirogyra on bio growth performance, digestive enzyme activity and haematology of E. suratensis. The experiment was performed with different levels of Spirogyra incorporated diet - S0, 10, 12.5, 15, 17.5, 20, 22.5 and 25%. The pearlspot fingerlings of initial weight of 14.91±0.11 was stocked in the 300 litre FRP tank for 60 days. Result: The highest growth performance of pearlspot was found in 22.5% Spirogyra incorporated diet. The average weight gain was highest in 22.5% SP (26.55±0.22 g), followed by 20% SP (26.11±0.25 g), control (25.83±0.47 g), 25% SP (24.78±0.15 g), 17.5% SP (24.46±0.16 g), 15% SP (23.03± 0.16 g), 12.5% SP (22.21±0.34 g), 10% SP (22.16±0.80 g). The digestive enzyme activity of amylase (0.026±0.001 U mg protein-1 min-1), protease (0.164±0.02 U mg protein-1 min-1) and lipase (0.486±0.01 U mg protein-1 min-1) were found to be highest in 22.5%SP treatment, followed by other treatments. The haematology parameters RBC and WBC count increased with increase in the incorporation of Spirogyra in diet. The study concluded that the incorporation of Spirogyra at 22.5% improved the growth performance and feed utilization of pearlspot.
Decoding Asset Turnover: Insights into Financial Dynamics of the Automotive Sector
Authors: Mubarok Faizul , Rentika Della , Himawan Farras Azhar Ananda , El Ghifari Muhammad Sheva
Published: January 2025

Purpose: The primary aim of this research study is to explore and analyze the interrelationships among profitability, leverage, liquidity, and interest rates in the context of the asset turnover ratio within automotive companies.

Method: The research employs a purposive sampling method, selecting automotive companies as the research subjects from 2018 to 2022. A panel data regression approach is utilized to analyze the data, specifically employing the Random Effect Model.

Results: The results of this research show that profitability, leverage and interest rates have a significant effect on the asset turnover ratio. In contrast, this research reveals a negative relationship between liquidity and ATR.

Implications: The implication of this research is that stakeholders in the automotive industry, including management, investors, and policy makers, can use the insights obtained to make informed decisions. This study also provides practical implications for optimizing asset utilization strategies in automotive companies. The research findings contribute to existing knowledge in the fields of finance and management, enriching understanding of the dynamics that shape company performance in the automotive sector.

Novelty: The novelty of this research lies in its comprehensive approach to understanding complex relationships in the context of asset turnover ratios, which have not previously been revealed in the automotive sector.
Rapid assessment tools for estimating trafficability of low volume roads
Authors: Rushing John , Edwards Lulu , Bell Haley , Ordaz Margarita
Published: January 2025

Rapid assessment of low-volume road surfaces remains a challenge when attempting to forecast allowable vehicle crossings. Variations in soil type, compaction effort, and moisture content of the soil can greatly affect trafficability, and predictive equations for soil deformation under vehicle loads often have reduced reliability for low-strength materials. Portable tools to characterize soil stiffness and corresponding relationships to load-induced deformation are needed. In this effort, researchers performed comparative testing of multiple rapid assessment tools as potential devices for giving estimations of vehicle trafficability. The test devices included a Clegg hammer and light weight deflectometer as instruments that measure response from impulse loading. Silty sand with and without chemical stabilization (using cement) at varying moisture content were used for testing. These soil states represented very weak conditions capable of supporting fewer than 50 vehicle passes to moderate strength conditions capable of supporting several thousand vehicle passes. Data from full-scale tests were used to correlate allowable traffic with data obtained from the rapid assessment tools. Recommendations from the effort include ranges of response data to categorize low-volume road surfaces based on their ability to handle ranges of vehicle loadings.
Assessment and Improvement of Nutritive Value of Agricultural Residue Feed for Caprine
Authors: SHITTU Oluwatosin K. , ABDULKAREEM Biliksu , ALADE Halimat B. , TIJANI Jimoh O.
Published: January 2025

The use of agricultural residues as caprine feed is essential for sustaining livestock, and ensuring food security. However, the presence of fungal communities in these residues poses a threat to the feed quality and animal health. This study aimed to determine the fungal diversity and optimize of selenium nanoparticle (SeNPs) biosynthesis for antifungal scavengers for the feeds. The isolation and identification of the fungal species were characterised through morphological, microscopic, and phylogenetic analyses. The optimization of SeNPs was done using sodium selenite concentration, pH, and incubation time. While characterized was carried out with ultraviolet-visible spectroscopy (UV-Vis), and ZETA sizer. The presence of fungal species such as Aspergillus flavus, Rhizopus species, Aspergillus niger, Trichophyton rubrum, Mucor sp., Macrosporium audounii, Epidermophyton floccosum, Verticillium tenesum, Tricophytonmetagrophi and Exophialajeanselmei was confirmed across the feeds. With fungal load of varying concentrations ranging from 1.76 x 104cfu/g of bean husk (BH) to 6.08 x 104cfu/g of groundnut husk (GOH) was also confirmed. The evolutionary classification of the fungi isolated showed a monophyletic pattern of Aspergillus flavus species clustered with a bootstrap of 59%. The best condition for synthesizing PT-SeNPs was confirmed has 7 days of incubation time, 2mM of PT concentration and pH 6. The PT-SeNPs with particle size of 26.30 nm at wavelength of 300 nm show antifungal activity against Aspergillus nidulans (24.25 ± 0.45 mm) at 3.0ml. Hence, the present of toxigenic fungi in agricultural residue feed for caprine requires proper safety measures and the potential of PT-SeNPs as an antifungal scavenger for Aspergillus contamination.
Structural and mechanistic study of a novel inhibitor of M. tuberculosis cytochrome bc1:aa3
Authors: Lamers Meindert , Verma Amit , Kim Robbert , Lamprecht Dirk , Pérez Clara Aguilar , Wong Sarah , Veziris Nicolas , Aubry Alexandra , Bartolomé-Nebreda José Manuel , Carbajo Rodrigo , Wetzel Jennefer
Published: January 2025

Drug-resistant tuberculosis (TB) continues to challenge treatment options, necessitating the exploration of new compounds of novel targets. The mycobacterial respiratory complex cytochrome bc1:aa3 has emerged as a promising target, exemplified by the success of first-in-class inhibitor Q203 in phase 2 clinical trial. However, to fully exploit the potential of this target and to identify the best-in-class inhibitor more compounds need evaluation. Here, we introduce JNJ-2901, a novel inhibitor of the M. tuberculosis cytochrome bc1:aa3, demonstrating activity against multidrug-resistant M. tuberculosis clinical strains at sub-nanomolar concentration and 4-log reduction in bacterial burden in mouse model of TB infection. Inhibitory studies on purified enzyme validate the nanomolar inhibitions observed in mycobacterial cells. Additionally, cryo-EM structure analysis of cytochrome bc1:aa3 bound to JNJ-2901 reveals the binding pocket at the menaquinol oxidation site (Qp), akin to other substate analogue inhibitors like Q203 and TB47. Validation of binding site is further achieved by generating and isolating the JNJ-2901 resistant mutations in M. tuberculosis, followed by purification and resistance analysis of the resistant cytochrome bc1:aa3 complex. Our comprehensive work lay the foundation for further clinical validations of JNJ-2901.
The Cenozoic Evolution of Earth’s Strongest Geoid Low: Insights into Mantle Dynamics below Antarctica
Authors: Glišović Petar , Forte Alessandro
Published: January 2025

Constraining the long-term evolution of geoid anomalies is essential for unraveling Earth's internal dynamics. While most studies focus on present-day geoid snapshots, we reconstruct the time-dependent evolution of Earth’s strongest geoid depression, the Antarctic Geoid Low (AGL), over the Cenozoic. Unlike geodetic reference frames that place the deepest geoid low in the Indian Ocean, a geodynamic perspective (relative to a hydrostatic ellipsoid) reveals the strongest nonhydrostatic geoid depression actually resides over Antarctica. Using a back-and-forth nudging technique for time-reversed mantle convection modeling, we leverage 3-D mantle density structures derived from seismic tomography and geodynamic constraints. Our results show that the AGL has persisted for at least ~70 Myr, undergoing a major transition in amplitude and position between 50 and 30 Ma. This coincides with abrupt lateral shifts in Earth’s rotation axis at ~50 Ma, validated through paleomagnetic constraints on True Polar Wander. Initially, stable lower mantle contributions dominated the AGL, but over the past ~40 Myr, increasing upper-mantle buoyancy, particularly above ~1300 km depth, amplified the AGL magnitude. This shift stems from the interplay between long-term deep subduction beneath the Antarctic Peninsula and a buoyant, thermally driven upwelling of hot, low-density material from the lowermost mantle. These new results contrast with earlier interpretations, clarifying the crucial role of evolving mantle buoyancy in shaping global geoid anomalies. By incorporating seismic, geodynamic, and mineral-physics data, our reconstructions provide a more comprehensive understanding of mantle flow beneath Antarctica and offer new insights into the dynamic coupling between lower and upper mantle processes that govern Earth’s long-wavelength geoid evolution.
A Fiber Array Architecture for Atom Quantum Computing
Authors: Xu Peng , Li Xiao , Hou Jia-Yi , Wang Jia-Chao , Wang Guang-Wei , He Xiao-Dong , Zhou Feng , Wang Yibo , Liu Min , Wang Jin , Zhan Mingsheng
Published: January 2025

Arrays of single atoms trapped in optical tweezers are increasingly recognized as a promising platform for scalable quantum computing. In both the fault-tolerant and NISQ eras, the ability to individually control qubits is essential for the efficient execution of quantum circuits. Time-division multiplexed control schemes based on atom shuttling or beam scanning have been employed to build programmable neutral atom quantum processors, but achieving high-rate, highly parallel gate operations remains a challenge. Here, we propose a fiber array architecture for atom quantum computing capable of fully independent control of individual atoms. The trapping and addressing lasers for each individual atom are emitted from the same optical waveguide, enabling robust control through common-mode suppression of beam pointing noise. Using a fiber array, we experimentally demonstrate the trapping and independent control of ten single atoms in two-dimensional optical tweezers, achieving individually addressed single-qubit gates with an average fidelity of 0.9966(3). Moreover, we perform simultaneous arbitrary single-qubit gates on four randomly selected qubits, resulting in an average fidelity of 0.9961(4). Our work paves the way for time-efficient execution of quantum algorithms on neutral atom quantum computers.
Enhancing Transparency and Trust in Brain Tumor Diagnosis: An In-Depth Analysis of Deep Learning and Explainable AI Techniques
Authors: Kumar Krishan , Jyoti Kiran
Published: January 2025

Brain tumors pose significant health risks due to their high mortality rates and challenges in early diagnosis. Advances in medical imaging, particularly MRI, combined with artificial intelligence (AI), have revolutionized tumor detection, segmentation, and classification. Despite the high accuracy of models such as Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs), their clinical adoption is hampered by a lack of interpretability. This study provides a comprehensive analysis of machine learning, deep learning, and explainable AI (XAI) techniques in brain tumor diagnosis, emphasizing their strengths, limitations, and potential to improve transparency and clinical trust. By reviewing 53 peer-reviewed articles published between 2017 and 2024, we assess the current state of research, identify gaps, and provide practical recommendations for clinicians, regulators, and AI developers. The findings reveal that while XAI techniques, such as Grad-CAM, SHAP, and LIME, significantly enhance model interpretability, challenges remain in terms of generalizability, computational complexity, and dataset quality. Future research should focus on addressing these limitations to fully realize the potential of AI in brain tumor diagnostics.
Seasonal Dynamics and Host Factors Influencing Eustrongylides spp. Infestation in Spotted Snakeheads, Channa punctata in Mymensingh, Bangladesh
Authors: Tanwi Jarin Tasnim , Dey Anita Rani , Raihan Johir , Mahamud A.G.M.Sofi Uddin , Hossain Siyam , Suchona Julfat Tasnim , Nibir Salman Shahriar , Keya Tabassum , Juthy Jubaida Parveen , Bushra Savayan Sadad , Paul Sandhya , Kubra Khadiza Tul , Faruk Md. Ali Reza , Rahman Tanvir
Published: January 2025

Eustrongylides nematodes represent an emerging zoonotic threat, especially with the increasing global consumption of raw or undercooked fish. The present study aimed to investigate the seasonal variation of Eustrongylides spp. infestation in spotted snakehead, Channa punctata, from August 2020 to July 2021 and to assess the influence of the host. A total of 414 experimental C. punctata, captured from the ditches and beels connected with the Brahmaputra river, were collected for 12 months from three adjacent fish markets under Mymensingh Sadar sub-district, Mymensingh, Bangladesh. Stage four larval (L4) Eustrongylides spp. were isolated from the abdominal cavity, musculature, and ovaries of 133 sampled fish, washed with 0.85% sterile physiological saline and examined under light microscope using lactophenol. Prevalence was recorded as 32.12%, with a notable mean intensity of 1.53 and an abundance of 0.49. The highest prevalence was found in autumn (45.83%). Larger fish (>18 cm) exhibited a higher prevalence (62.1%) compared to the smaller (<13 cm) (26.5%). Interestingly, females had a higher prevalence and mean intensity of infestation (35.7%, 1.69±0.10) compared to males (27.2%, 1.24±0.06). Results indicated that female and higher-weighted fish exhibit higher parasitic prevalence in C. punctata, likely due to biological and environmental factors and the immunity level of the host.
Agaricus blazei extract FA-2b-β inhibits microglial pyroptosis by regulating the activation of the NF-κB signaling pathway mediated by Aβ 1-42 through the NLRP3 pathway
Authors: Xi Zujun , Yuan Jin , Fan Junshun , Sun Yanqing
Published: January 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Intracellular neurofibrillary tangles (NFTs) and neuroinflammatory plaques formed by amyloid-β (Aβ) are the main pathological features of AD. FA-2b-β, a selenium mushroom extract from Qinba, had strong anti-inflammatory activity and could protect against various inflammatory diseases by regulating multiple signaling pathways. However, whether FA-2b-β can modulate Aβ1−42-mediated neuroinflammation by inhibiting the NF-κB signaling pathway has not been systematically investigated. The present study aimed to explore the effect and mechanism of action of FA-2b-β on Aβ1−42-mediated microglia inflammation. The results showed that FA-2b-β reduced Aβ1−42-mediated release of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and the expression of key proteins of NF-κB signaling pathway TLR4 and p-IκB-α, and NLRP3 Inflammasome associated with NLRP3 and Caspase1. However, activation of the NF-κB signaling pathway activates NLRP3 inflammasome and leads to increased expression of pyroptosis key protein GSDMD. Further, knockout of NLRP3 and FA-2b-β intervention, respectively, in BV2 cells resulted in a corresponding reduction in the levels of inflammatory mediators, including NLRP3, Casp1, ASC, TNF-α, and IL-1β. Mechanistically, FA-2b-β inhibited activation of nuclear factor kappa B (NF-κB) and downregulated the Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) protein expression to suppress pyroptosis of BV2 cells. These findings suggested that FA-2b-β might represent a potential therapeutic agent for anti-neuroinflammation.
In Navigation from LSE to AI. Application of RNN to GA Based BGPS and RTK-B Positioning
Authors: II Ivan G. Petrovski
Published: January 2025

We have developed instant positioning method BGPS™ and RTK-B using an application of genetic algorithms (GA), first mentioned in [1], and then detailed in [2],[3]. The integration of genetic algorithms for carrier ambiguity resolution and compact continuum transformation algorithms for computational complexity reduction allows for the attainment of more accurate and reliable positioning solutions with reduced initialization times and elevated integrity (see [4] and [5]) In this paper we research new level of AI (artificial intelligence) application for navigation by introducing an enhancement of the poisoning algorithms with recurrent neural networks (RNN) to improve GA convergence and paving a way for AI application for navigation in the future.
A Hybrid ODE-Neural Network Framework for Modeling and Guiding GLP-1-Mediated Glucose Dynamics
Authors: Wang Zijia , Sumbal Sarwar , Toumazou Christofer
Published: January 2025

Accurate modeling of glucose dynamics in response to Glucagon-like peptide-1 (GLP-1) is essential for understanding metabolic regulation and optimizing therapeutic interventions for diabetes and obesity. Traditional mechanistic models often oversimplify the relationship between GLP-1 and glucose by neglecting complex intermediary variables such as insulin, glucagon, and free fatty acids. To address this limitation, we propose a hybrid modeling framework that integrates ordinary differential equations (ODEs) with neural networks (NNs), thereby combining mechanistic insights with data-driven flexibility. Our model explicitly incorporates multiple intermediary metabolic variables, enhancing physiological realism and predictive accuracy. Furthermore, the framework facilitates personalized GLP-1 injection guidance by accurately estimating required dosages based on continuous glucose monitoring (CGM) inputs, thereby preventing over-injection and improving therapeutic efficacy. We validate the framework using synthetic data generated by the 4GI model and real-world clinical data from the MIMIC-III database. The hybrid ODE-NN model demonstrates superior predictive performance, robustness to noisy and sparse data, and effective uncertainty quantification compared to purely mechanistic and purely data-driven baselines. Additionally, Bayesian parameter inference facilitates robust uncertainty estimation, crucial for clinical decision-making. Sensitivity analysis reveals key parameters influencing glucose dynamics, aligning with established endocrinological principles. This work underscores the potential of hybrid ODE-NN models in capturing the intricate dynamics of glucose regulation mediated by GLP-1, offering a powerful tool for metabolic research, personalized therapeutic strategies, and optimized GLP-1 injection protocols.
Land Cover Changes and Land Surface Temperature Dynamics in the Rohingya Refugee Area, Cox Bazar, Bangladesh: An Analysis from 2013 to 2024
Authors: Karmakar Sourav , Rahman Mizanur , Meng Lei
Published: January 2025

This study investigates the interplay between land use/land cover (LULC) changes and land surface temperature (LST) dynamics in the context of the Rohingya refugee crisis in Cox’s Bazar, Bangladesh, over the period 2013–2024. The study area comprises 34 refugee camps characterized by rapid anthropogenic transformation evaluated using Landsat 8 imagery. Key LULC categories, including Built-up, Mixed Forest, Waterbodies, and Barren Land, were analyzed using supervised classification based on SVM methods and multi-temporal indices like NDVI, NDWI, and NDBI. The Mono-Window Algorithm was employed to derive LST. Our results suggest an upward trend in LST, particularly in densely urbanized zones. Results also indicate a 97% decline in forest cover and a 161.78% increase in built-up areas between 2013 and 2018, corresponding to a substantial rise in LST. Statistical analyses confirm strong correlations between LST and LULC indices, with vegetation and water bodies acting as natural cooling agents, while urbanized areas amplify thermal stress. The study highlights the significant environmental impact of refugee settlements, emphasizing the conversion of forested areas to urban spaces and the resulting increase in LST. The findings underscore the urgent need for sustainable land use strategies, reforestation, and urban planning to mitigate LST increases and environmental degradation. This study highlights the necessity of coordinated international efforts for refugee repatriation to reduce environmental strain. These insights contribute to the growing body of knowledge on the environmental impact of large-scale human displacement, providing a basis for policy development and climate resilience planning in vulnerable regions.
Comparison of the H3B2A1 score with other risk models for upper gastrointestinal bleeding
Authors: fındık meliha , çakas muhammet , önler ahmet buğra
Published: January 2025

Background: Acute gastrointestinal (GI) bleeding is a critical emergency and a significant cause of morbidity and mortality worldwide, with rates ranging between 5% and 10%, despite advancements in treatment. Upper gastrointestinal bleeding (UGIB) accounts for a substantial proportion of cases, particularly in elderly populations with comorbid conditions.
Methods: This retrospective study evaluated the predictive accuracy of the H3B2A1 scoring model for mortality and intensive care unit (ICU) admission in UGIB patients. The AIMS65, Glasgow-Blatchford score (GBS), modified GBS (mGBS), and H3B2 scores were calculated for all patients. Receiver operating characteristic (ROC) curves were used to assess the scores' predictive performance.
Results: Compared with the AIMS65 score, the H3B2A1 score demonstrated comparable predictive accuracy for mortality (H3B2A1-AUC: 0.750; AIMS65-AUC: 0.754), with all the scores showing moderate accuracy (AUC = 0.7–0.9). In predicting ICU hospitalization, the AIMS65 score outperformed the other scores (AUC: 0.844; sensitivity: 96.1%), followed by H3B2 (82.4%).
Conclusion: The H3B2A1 model (modified H3B2), which incorporates albumin into the H3B2 score, provides a practical tool for assessing mortality risk, ICU admission, and the need for emergency endoscopy in UGIB patients. Its simplicity and predictive power makes it a valuable addition to clinical practice.
Design, synthesis and evaluation of novel selective macrocyclic kinase inhibitors
Authors:   , Gerninghaus Joshua
Published: January 2025

This work presents the iterative exploration and optimization of starting point macrocycle 11, enabled by a wide range of in-vitro and cellular experiments, as well as structure-guided design supported by co-crystallisation experiments. The most promising candidates from four distinct SAR studies were subjected to evaluation in an anti-DENV infection assay and a CRC organoid model, with the objective of gaining insight into their biological relevance. The observed efficacy of macrocycle 65 in the DENV infection assay provides a foundation for further investigation of a potential mechanistic link between EPHA2 and infection with DENV. The selectivity of compounds 85 and 89 for EPHA4 in a cellular context offers a promising avenue for the development of an EPHA4 tool compound. A co-crystallisation experiment of 156 in complex with the most potently addressed off-targets could support a structure-guided design approach for further tuning the selectivity towards EPHA2 and ultimately uncovering a probe compound. This remains an effort of future investigations.
Evaluation klinischer Prädiktoren für ein unzureichendes Ansprechen einer nasalen Highflow-Therapie bei Patienten mit akuter respiratorischer Insuffizienz bei ambulant wie nosokomial erworbener Pneumonie
Authors:   , Gaillard Matthieu
Published: January 2025

Die akute respiratorische Insuffizienz ist die häufigste Komplikation von Pneumonien auf Intensivstation. In den letzten Jahren haben nicht invasive Beatmungstherapien immer mehr an Bedeutung gewonnen. Während das Versagen der nicht-invasiven Ventilation bereits gut untersucht ist, sind Risikofaktoren für ein unzureichendes Ansprechen auf eine Highflow-Therapie noch nicht abschließend erfasst worden.
Deshalb führten wir eine retrospektive monozentrische Studie zur Identifikation jener Risikofaktoren für ein unzureichendes Ansprechen oder ein Versagen von Highflow- Therapie zur Behandlung akuter respiratorischer Insuffizienz durch eine Pneumonie auf Intensivstation durch.
Insgesamt wurden 245 Patienten eingeschlossen, die zwischen Januar 2019 und November 2021 mit einer Pneumonie auf einer Intensivstation des Universitätsklinikum Frankfurt am Main unter anderem mit einer Highflow-Therapie behandelt wurden. Es wurden soziodemographische Faktoren, Risikofaktoren, Vorerkrankungen, laborchemische Analysen, Vitalparameter und arterielle Blutgasanalysen erhoben.
In der Gesamtpopulation waren das Alter, der paO2, die Sauerstoffsättigung und der Oxygenierungsindex in der ersten arteriellen BGA nach Beginn der Highflow-Therapie und die Atemfrequenz bei Beginn der Highflow-Therapie signifikante Risikofaktoren für ein unzureichendes Ansprechen auf die Therapie und eine daraus folgende Intubation bzw. ein Versterben der Patienten auf Intensivstation.
Des Weiteren waren bei den COVID-19 Patienten die Höhe des Harnstoffs und des Kreatinins in der ersten laborchemischen Analyse nach Aufnahme auf Intensivstation ein signifikanter Risikofaktor für das Versagen einer Highflow-Therapie.
Bei den non-COVID-19 Patienten war das Vorliegen einer hämatologischen Grunderkrankung ein signifikanter Risikofaktor für ein unzureichendes Ansprechen auf eine Highflow-Therapie.
Auch der bei Beginn der Highflow-Therapie erfasste ROX-Index war signifikant und der in der Literatur beschriebene Trennwert von 4,88 sagte in unserer Studie ein Therapieversagen erfolgreich voraus. Unsere Ergebnisse deuten darauf hin, dass eine Anpassung des Grenzwertes des ROX-Indexes für COVID-19 Pneumonien sinnvoll sein könnte.
Außerdem konnten wir mit dem CRB65-Score und dem qSOFA-Score bei Beginn der Highflow-Therapie und bei ersterem auch bei Aufnahme signifikante Vorhersagen für das Therapieversagen treffen. Die Erweiterung des qSOFA Scores um den Oxygenierungswert konnte diese Vorhersagen noch weiter verbessern.
THE FATWAS OF AHMAD KHATIB MINANGKABAU (1860-1916) AND RELIGIOUS AUTHORITY IN INDONESIA
Authors: J.G. Kaptein Nico
Published: January 2025

Ahmad Khatib originated from Minangkabau, West Sumatra and after his settlement in the Holy City of Mecca in 1877, he grew into a scholar in Islamic sciences of great repute and eventually died there in 1916. His written work, educational and other activities have played a vital part in the exchange of religious ideas between Mecca and the Malay-Indonesian archipelago and make him an important person in the history of Islam in Southeast Asia. In my paper I will go in detail into a fatwa he gave on the question of whether or not it was allowed to sell chickens to Chinese. The paper aims to shed light on the mufti-ship of Ahmad Khatib and will look into the wider implications of the issue as far as religious authority is concerned, in particular into its locus.
Relato de experiências sobre oficinas de aromaterapia e intervenções em Coxim-MS
Authors: PEIXOTO Lucas Silva , SANTANA Clistiane Santos , OLIVEIRA Daniel Emanuel Cabral de , FAVARETO Rogério , BICHOFF Amanda , FERNANDES Darlene Marques , FREITAS Rutinéia Martins , RODRIGUES Mariza da Silva , BORGES João Paulo Assunção
Published: January 2025

A aromaterapia é uma Prática Integrativa e Complementar em Saúde (PICS) que envolve a aplicação de óleos essenciais (OE), promovendo benefícios à saúde física e mental. Objetivou-se relatar as experiências com oficinas de aromaterapia para profissionais de saúde e acadêmicos de enfermagem em Coxim, na região norte de Mato Grosso do Sul, entre 2023 e 2024. Consistiram em ações de educação permanente em saúde, com formação teórico-prática. Abordaram-se conceitos e definições, características dos OE, formas de extração, aplicabilidade prática e indicações. Foram realizadas sessões de aromaterapia, na forma de escalda-pés e aplicação de OE, em intervenções nas unidades de saúde e eventos com a comunidade, na forma de extensão universitária. Evidenciou-se a aplicação prática em campo da aromaterapia, bem como sua aceitação e adesão pela comunidade. Identificou-se o ensino incipiente das PICS e que atividades de extensão universitária são importantes espaços de formação acadêmica. Os profissionais de saúde ampliaram a carteira de serviços ofertados na prática assistencial, destacando a importância da educação permanente em saúde para melhorar a qualidade e integralidade das ações de saúde.
Critical analysis of multiple reentrant localization in an antiferromagnetic helix with transverse electric field: Hopping dimerization-free scenario
Authors: Ganguly Sudin , Chattopadhyay Sourav , Mondal Kallol , Maiti Santanu K.
Published: January 2025

Reentrant localization (RL), a recently prominent phenomenon, traditionally links to the interplay of staggered correlated disorder and hopping dimerization, as indicated by prior research. Contrary to this paradigm, our present study demonstrates that hopping dimerization is not a pivotal factor in realizing RL. Considering a helical magnetic system with antiferromagnetic ordering, we uncover spin-dependent RL at multiple energy regions, in the absence of hopping dimerization. This phenomenon persists even in the thermodynamic limit. The correlated disorder in the form of Aubry-André-Harper model is introduced by applying a transverse electric field to the helical system, circumventing the use of traditional substitutional disorder. We conduct a finite-size scaling analysis on the observed reentrant phases to identify critical points, determine associated critical exponents, and examine the scaling behavior linked to localization transitions. Additionally, we explore the parameter space to identify the conditions under which the reentrant phases occur. Described within a tight-binding framework, present work provides a novel outlook on RL, highlighting the crucial role of electric field, antiferromagnetic ordering, and the helicity of the geometry. Potential applications and experimental realizations of RL phenomena are also explored.
The Influence of PBL-Based Worksheets on Interest and Learning Outcomes
Authors: Sari Tri wulan , Muhammad Iqbal Filayani
Published: January 2025

This research is motivated by students' difficulty understanding the material taught, the tendency of learning processes to be boring, and the continued use of conventional teaching materials. This study aims to determine the influence of using PBL-based worksheets on students' interests and learning outcomes. This research is quantitative in nature with a quasi-experimental design. Data collection methods in this study include questionnaires, tests, and documentation. Subject matter experts and media experts conducted the validity test. The data analysis technique used is quantitative descriptive analysis. The results show a significant positive influence between using PBL-based worksheets and interest and learning outcomes. This is based on the results of MANOVA tests using questionnaire results and N-Gain values, which obtained a Sig. (2-tailed) value of 0.000, indicating the influence of using PBL-based worksheets on interest and learning outcomes.
Efeito da insolação na sanidade de abelhas Apis mellifera (africanizadas) no Semiárido Brasileiro
Authors:   , Souza Franklin Amaro de
Published: January 2025

As abelhas africanizadas (Apis mellifera) da região do Semiárido Potiguar
apresentam duas doenças principais: A varroatose cujo agente é o ácaro Varroa destructor, e
a nosemose, recentemente introduzida no estado, cujo agente foi identificado anteriormente
na região dos apiários experimentais como sendo o microsporídio Nosema ceranae. Os
objetivos desta pesquisa foram avaliar os efeitos diretos da insolação e do sombreamento
sobre colmeias em relação à taxa de infestação do ácaro em abelhas adultas e nas crias;
sobre o comportamento higiênico e sobre a doença nosemose. O experimento foi realizado
no CETAPIS/UFERSA em Mossoró, RN, onde, utilizou-se 10 colmeias instaladas sob uma
latada construída no sentido leste-oeste, coberta com folhas de coqueiro que absorvia cerca
de 90% da insolação e, outras 10 sob efeito direto da insolação. As coletas foram feitas no
período da safra (chuvoso), nos dias 30/01, 20/03, 09/4 e 10/05, e no período da entressafra
(seca), nos dias 18/08, 23/09, 07/10 e 30/11. Os resultados mostraram que durante o período
de entressafra as colmeias instaladas na sombra apresentaram uma taxa de infestação média
(%) (6,54 ± 0,59) em abelhas adultas menor (P<0.01) do que nas colmeias instaladas no sol
(9,71 ± 1,02). Embora os resultados tenham mostrado uma tendência de infestação menor
nas crias em colmeias instaladas na sombra, em relação as instaladas no sol, não foram
observadas diferenças significativas (P=0.253). Já o comportamento higiênico (%) foi muito
baixo para as colmeias na sombra e no sol (57, 61 ± 6,44 e 57,33 ± 7,96) respectivamente.
No entanto, observou-se uma correlação negativa significativa entre este comportamento e a
taxa de infestação do ácaro em abelhas adultas. Quanto à nosemose, foram encontrados
esporos em todas as colmeias tanto no sol quando na sombra, mas no entanto, o número
médio de esporos por abelha pode ser considerado muito baixo, sendo significativamente
maior no período de safra (200.000 ± 40. 869) do que na entressafra (31.250 ± 3.900), no
entanto, não se obteve diferenças significativas entre as colmeias na sombra e no sol.
Implementation of an integrated, clinical decision support tool at the point of antihypertensive medication refill request to improve hypertension management (Preprint)
Authors: Matulis 3rd John Charles , Greenwood Jason , Eberle Michele , Anderson Benjamin , Blair David , Chaudhry Rajeev
Published: January 2025

BACKGROUND

Improved processes around the management of Electronic Health Record (EHR) requests for chronic antihypertensive medication renewals may represent an opportunity to improve blood pressure management at the individual and population level.

OBJECTIVE

This study aimed to evaluate the effectiveness of The eRx HTN Chart Check, an integrated clinical decision support tool available at the point of antihypertensive medication refill request, to facilitate enhanced provider management of chronic hypertension.

METHODS

The study was conducted at 2 Mayo Clinic sites, Northwest Wisconsin Family Medicine and Rochester Community Internal Medicine practices, with control groups in comparable Mayo Clinic practices. The intervention integrated structured clinical data, including recent blood pressure readings, lab results, and visit dates, into the electronic prescription renewal interface to facilitate prescriber decision making around hypertension management. A Difference-in-Differences (DID) design compared pre- and post-intervention hypertension control rates in the intervention and control groups. Data were collected from the Epic EHR system and analyzed using linear regression models.

RESULTS

The baseline blood pressure control rates were slightly higher in intervention clinics. Post-implementation, no significant improvement in population-level hypertension control was observed (DID estimate: 0.07%, 95% CI: -4.0% to 4.1%; p = 0.973). Of the 19,968 refill requests processed, 46% passed all monitoring criteria. However, clinician approval rates remained high (90%), indicating minimal impact on prescribing behavior.

CONCLUSIONS

Despite successful implementation of the eRx HTN Chart check tool, exposed practices did not see significant improvements in hypertension control, possibly due to competing quality initiatives and high in-basket volumes. Future iterations should focus on enhanced integration with other decision support tools and strategies to improve clinician engagement and patient outcomes. Further research is needed to optimize chronic disease management through EHR-integrated decision support systems.

CLINICALTRIAL

N/A
Modification of Chitosan-Coated Magnetic Material with Glycidyl-trimethylammonium Chloride for Cr(VI) Adsorption
Authors: Kamilia Salwa , Mukhayani Feri , Sutarno Sutarno , Nuryono Nuryono
Published: January 2025

Modification of chitosan-coated magnetic material with quaternary ammonium chloride as adsorbent for Cr(VI) anions has been studied. The works included magnetic material (MM) separation from iron sand, magnetic material-chitosan (MM/Chit) synthesis, and attachment of quaternary ammonium groups from glycidyl trimethyl ammonium chloride (GTMAC) on MM/Chit to produce MM/Chit/GTMAC with various mass ratios. Products were characterized with FTIR, XRD, SEM-EDX, and VSM. Adsorption studies were carried out in a batch system with pH, time, and initial Cr(VI) concentration variations. The unadsorbed Cr(VI) was analyzed with AAS, and the adsorbed Cr(VI) was calculated from the difference between initial and unadsorbed concentrations of Cr(VI). The results showed that MM/Chit/GTMAC was successfully synthesized, and adding GTMAC increased the stability of MM/Chit and shifted the optimum pH for Cr(VI) adsorption from 3.0 to 4.0. The study of kinetics and adsorption isotherm showed that the adsorption of Cr(VI) anion on the adsorbent MM/Chit/GTMAC (with the mass ratio of Chit to GTMAC 1:6) follows the pseudo-second-order kinetic model with the adsorption rate constant of 5.3 × 10−3 g mg−1 min−1 and Langmuir isotherms with the adsorption maximum capacity of 104.17 mg g−1, which has a potential to be applied for removing Cr(VI) from polluted wastewater.
Living Networks
Authors: Johnson Anna , Black Richard
Published: January 2025

Working from the periphery on Djaara Country, Castlemaine Regional Victoria,140km out of Melbourne, our proposal starts from the centre of this old gold mining town and seeks to document and capture our more-than-architectural endeavour. For this narrative, the architect’s business is as much about observing and taking note, revealing and paying heed to the invisible and often intangible systems of just what’s there now. Drawing from a Kraussian expanded architectural field, we have evolved a design process of building site knowledge and context that uncovers the histories, peripheral stories, forgotten memories and patterns of occupation. In seeking solutions to accommodate a growing community, to house those now homeless and to give more agency to our Indigenous people, we reflect on currently accepted design strategies and propose an alternative model that rethinks property boundaries and ownership, occupancy and vacancy regulations.  Our work has been resisting the additions of new buildings and instead foregrounds what already exists, to recast the accumulations of built fabric and of its interstitial landscapes as inherently value filled. In doing this we reveal an eclectic town fabric, a mix of industrial, Victorian and 20th century material that holds traces of past occupation but also reflects a kind of vibrant eclecticism that speaks more to a possible future than carbon-hungry developer-led solutions. Our essay will build an alternative spatial narrative that makes visible a process that tracks and traces the voices of those invisible and marginalized protagonists as well as the value of existing built fabric. What we aim to construct is not more built stuff, but a more robust future that accepts what is already there; the ordinary, the unremarkable as well as remarkable. Our conclusions and contributions are as much in spatialising and making active – sensible – those forgotten and intangible voices and peripheral built heritages.
De-constructing the Sense of Inside and the Outside in a Chawl
Authors: Morwal Aishwarya
Published: January 2025

The chawl is a housing typology from western India, known especially for its overwhelming population density and strong sense of community living, comprised of several small, tightly spaced units connected by a common veranda. Built predominantly in the early 1900s, chawls were commonly adopted in cities like Mumbai and Ahmedabad, which rapidly absorbed working-class populations migrating from villages to work in the booming textile industries. The Cotton Chawl, built in 1935 in Ahmedabad, is one such three-storied chawl, housing 87 units. Comprising only one room and a small kitchenette, generally used by 4-5 family members, the household units in the chawl often spill out onto the 3-foot-wide veranda. Activities such as sitting, conversing, performing everyday domestic tasks, celebrating religious ceremonies, and even sleeping take place on the veranda, which becomes a complex site at the intersection of personal and collective life. The close-knit architecture of the chawl gives people the sense of an extended home, outside the individual house unit, where language, behaviors, movement, and interactions are all shaped by people’s perceptions of privacy, gender norms, and shared understandings of social and cultural codes. Understanding the spatio-temporal rhythms of these activities, I use oral history and ethnography to understand how terms like inside and outside, private and public, and the home and the world have deeply specific and relational meanings. I illustrate how physical demarcations of inside and outside are highly inadequate to understand how space is truly used. My central argument is that, in community settlements like the chawl, spatial demarcations of architecture don’t necessarily correspond with the metaphorical, embodied, and ideological conceptions of place. Here, common spaces like the balcony are not merely containers of activities, but they are produced from the very activities and relationalities of time and people's acts, constantly imbuing newer meaning within them.
Formulation and Evaluation of Herbal Toothpaste
Authors: Shelke Mr. Akash Kailas
Published: January 2025

Toothpaste is commonly used product by all individuals. Toothpaste is generally used forcleaning of teeth and mouth.
It is also used to treat many disorders of teeth. Many dentistsrecommend to use toothpaste to treat disorder like sensitivity,
Chronic gingivitis. Herbal toothpastes can be prepared using different herbal extract of many crude drugs havingantibacterial,
antimicrobial activity. Herbal formulation of toothpastes are prepared using herbs like ginger, Cassia, simmia, Celastrus,
paniculata, Vateria, indica extracts, Babul leaves extract, Ginger extract, Lemon oilextract, Neem stem & bark, Babul leaves,
Gauva leaves, Kalmi bark etc. These herbal toothpastes can be evaluated by different tests like Physical Examination, Relative
density, Abrasiveness, Determination of spreadability, pH determination, Homogenicity, Foaming Stability, Determination of
moisture and volatile matter, Moisture content, Foaming character, Organoleptic evaluation, pH, Fragrance test, Shape
retention, Storage stability, Total flavonoid content estimation of Tooth paste Formulation, Stability study (Storage stability),
Antimicrobial activity of toothpaste etc. The main objective of this review article is to compile the available information related to
herbal toothpaste like its introduction, different formulations and different parameters on which these herbal toothpastes can be
evaluated. This information can be used by many researcher who wants to make research in this area.
Distance-preserving stabilizer measurements in hypergraph product codes
Authors: Manes Argyris Giannisis , Claes Jahan
Published: January 2025

Unlike the surface code, quantum low-density parity-check (QLDPC) codes can have a finite encoding rate, potentially lowering the error correction overhead. However, finite-rate QLDPC codes have nonlocal stabilizers, making it difficult to design stabilizer measurement circuits that are low-depth and do not decrease the effective distance. Here, we demonstrate that a popular family of finite-rate QLDPC codes, hypergraph product codes, has the convenient property of distance-robustness: any stabilizer measurement circuit preserves the effective distance. In particular, we prove the depth-optimal circuit in [Tremblay et al, PRL 129, 050504 (2022)] is also optimal in terms of effective distance.
The impact of the external environment on the social and health aspects of contemporary man in the dynamics of global social changes of the world
Authors: Costello M
Published: January 2025

The current issue of the journal features a truly international collection of timely articles. In addition to Slovakia, the authors are based in Pakistan, China and the United States.
Aesthetic Narcissism And Its Discontents. A Study of Kierkegaard’s “The Diary of the Seducer” and Its Relevance To Contemporary Clinical Psychology
Authors: Stan L. , Pavlikova M.
Published: January 2025

Aesthetic Narcissism And Its Discontents. A Study of
Kierkegaard’s “The Diary of the Seducer” and Its Relevance
To Contemporary Clinical Psychology
Parenta Awareness of Care for a Child with Gastroenteritis
Authors: Stofilova A. , Putekova S.
Published: January 2025

Objective: Gastroenteritis is a common illness affecting children and requires proper care to prevent complications. This
study aimed to determine the level of parental awareness about
caring for a child with gastroenteritis.
Methodology: We conducted the research using a quantitative
method in the form of a self-constructed questionnaire. A total of
52 respondents participated in the study, with a purposive sample consisting of parents of hospitalized children at the pediatrics clinic of the Faculty Hospital in Trnava. The questionnaire
was distributed between October and December 2023. The return rate of the questionnaire was 100%. We evaluated the questionnaire using Student‘s t-test and One-Way ANOVA test.
Results: Our findings indicate that most parents have
knowledge about gastroenteritis, recognize its symptoms, and understand the nursing care procedures for a child with this
condition. However, despite these findings, we identified deficiencies in the awareness of nursing care procedures for a
child with gastroenteritis.
Conclusion: Our research found no significant differences in
parental awareness regarding place of residence, number of
children in the household, level of education, and field of work.