bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Economy and Social Business Supporting Policies for Sustainable Human Development in a Post-COVID-19 World
Authors: Yunus Muhammad , Biggeri Mario , Testi Enrico
Published: November 2021

This paper explores the role that the social economy, and the social business within it, have in terms of the strategies deployed to tackle Sustainable Development challenges. This paper proposes a New Sustainable Recovery Approach (NSRA) leveraging the strengths of the social economy and social business to guide policymakers to rethink socio-economic actions for a post-COVID-19 world aimed at sustainable human development. The NSRA is based on three, self-reinforcing, components: the promotion of Sustainable Human Development (SHD) for everyone; a transformative approach to Education and Research for individual and collective learning processes; and a strong emphasis on a recovery driven by an “enhanced social and environmental consciousness and behavior”. The paper analyzes the role of the social economy and social business in the implementation of the NSRA. At the end of the paper, policy implications and final remarks are provided to policy makers.
Distance Fibonacci Polynomials by Graph Methods
Authors: Strzałka Dominik , Wolski Sławomir , Włoch Andrzej
Published: November 2021

In this paper we introduce and study a new generalization of Fibonacci polynomials which generalize Fibonacci, Jacobsthal and Narayana numbers, simultaneously. We give a graph interpretation of these polynomials and we obtain a binomial formula for them. Moreover by modification of Pascal’s triangle, which has a symmetric structure, we obtain matrices generated by coefficients of generalized Fibonacci polynomials. As a consequence, the direct formula for generalized Fibonacci polynomials was given. In addition, we determine matrix generators for generalized Fibonacci polynomials, using the symmetric matrix of initial conditions.
Lattice Constraints on the QCD Chiral Phase Transition at Finite Temperature and Baryon Density
Authors: Philipsen Owe
Published: November 2021

The thermal restoration of chiral symmetry in QCD is known to proceed by an analytic crossover, which is widely expected to turn into a phase transition with a critical endpoint as the baryon density is increased. In the absence of a genuine solution to the sign problem of lattice QCD, simulations at zero and imaginary baryon chemical potential in a parameter space enlarged by a variable number of quark flavours and quark masses constitute a viable way to constrain the location of a possible non-analytic phase transition and its critical endpoint. In this article I review recent progress towards an understanding of the nature of the transition in the massless limit, and its critical temperature at zero density. Combined with increasingly detailed studies of the physical crossover region, current data bound a possible critical point to μB ≳ 3T.
Magnetized Dusty Black Holes and Wormholes
Authors: Bronnikov Kirill A. , Kashargin Pavel E. , Sushkov Sergey V.
Published: November 2021

We consider the generalized Tolman solution of general relativity, describing the evolution of a spherical dust cloud in the presence of an external electric or magnetic field. The solution contains three arbitrary functions f(R), F(R) and τ0(R), where R is a radial coordinate in the comoving reference frame. The solution splits into three branches corresponding to hyperbolic (f>0), parabolic (f=0) and elliptic (f<0) types of motion. In such models, we study the possible existence of wormhole throats defined as spheres of minimum radius at a fixed time instant, and prove the existence of throats in the elliptic branch under certain conditions imposed on the arbitrary functions. It is further shown that the normal to a throat is a timelike vector (except for the instant of maximum expansion, when this vector is null), hence a throat is in general located in a T-region of space-time. Thus, if such a dust cloud is placed between two empty (Reissner–Nordström or Schwarzschild) space-time regions, the whole configuration is a black hole rather than a wormhole. However, dust clouds with throats can be inscribed into closed isotropic cosmological models filled with dust to form wormholes which exist for a finite period of time and experience expansion and contraction together with the corresponding cosmology. Explicit examples and numerical estimates are presented. The possible traversability of wormhole-like evolving dust layers is established by a numerical study of radial null geodesics.
Coinfection of Cotton Plants with Watermelon Mosaic Virus and a Novel Polerovirus in China
Authors: Yang Xiuling , Du Min , Li Shupeng , Zhou Xueping
Published: November 2021

Cotton is the most important fiber crop worldwide. To determine the presence of viruses in cotton plants showing leaf roll and vein yellowing symptoms in Henan Province of China, a small RNA-based deep sequencing approach was performed. Analysis of the de novo-assembled contigs followed by reverse transcription PCR allowed the reconstruction of watermelon mosaic virus and an unknown virus. The genome of the unknown virus was determined to be 5870 nucleotides in length, and has a genomic organization with characteristic features of previously reported poleroviruses. Sequence analysis revealed that the virus was closely related to, but significantly different from, cotton leafroll dwarf virus, a polerovirus of the family Solemoviridae. This virus had less than 90% amino acid sequence identity in the products of both ORF0 and ORF1. According to the polerovirus species demarcation criteria set by the International Committee on Taxonomy of Viruses, this virus should be assigned to a new polerovirus species, for which we propose the name “cotton leaf roll virus”.
Downregulation of Cell Surface Major Histocompatibility Complex Class I Expression Is Mediated by the Left-End Transcription Unit of Fowl Adenovirus 9
Authors: Griffin Bryan D. , Corredor Juan Carlos , Pei Yanlong , Nagy Éva
Published: November 2021

Major histocompatibility complex class I (MHC-I) molecules play a critical role in the host’s antiviral response by presenting virus-derived antigenic peptides to cytotoxic T lymphocytes (CTLs), enabling the clearance of virus-infected cells. Human adenoviruses evade CTL-mediated cell lysis, in part, by interfering directly with the MHC-I antigen presentation pathway through the expression of E3-19K, which binds both MHC-I and the transporter associated with antigen processing protein and sequestering MHC-I within the endoplasmic reticulum. Fowl adenoviruses have no homologues of E3-19K. Here, we show that representative virus isolates of the species Fowl aviadenovirus C, Fowl aviadenovirus D, and Fowl aviadenovirus E downregulate the cell surface expression of MHC-I in chicken hepatoma cells, resulting in 71%, 11%, and 14% of the baseline expression level, respectively, at 12 h post-infection. Furthermore, this work reports that FAdV-9 downregulates cell surface MHC-I through a minimum of two separate mechanisms—a lysosomal-independent mechanism that requires the presence of the fowl adenovirus early 1 (FE1) transcription unit located within the left terminal genomic region between nts 1 and 6131 and a lysosomal-dependent mechanism that does not require the presence of FE1. These results establish a new functional role for the FE1 transcription unit in immune evasion. These studies provide important new information about the immune evasion of FAdVs and will enhance our understanding of the pathogenesis of inclusion body hepatitis and advance the progress made in next-generation FAdV-based vectors.
Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2
Authors: Tang Qilong , Owens Raymond J. , Naismith James H.
Published: November 2021

Nanobodies are 130 amino acid single-domain antibodies (VHH) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular size, facile expression, high affinity and stability have combined to make them unique targeting reagents with numerous applications in the biomedical sciences. The first nanobody agent has now entered the clinic as a treatment against a blood disorder. The spread of the SARS-CoV-2 virus has seen the global scientific endeavour work to accelerate the development of technologies to try to defeat a pandemic that has now killed over four million people. In a remarkably short period of time, multiple studies have reported nanobodies directed against the viral Spike protein. Several agents have been tested in culture and demonstrate potent neutralisation of the virus or pseudovirus. A few agents have completed animal trials with very encouraging results showing their potential for treating infection. Here, we discuss the structural features that guide the nanobody recognition of the receptor binding domain of the Spike protein of SARS-CoV-2.
Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain
Authors: Nazerai Loulieta , Buus Søren , Stryhn Anette , Thomsen Allan Randrup , Christensen Jan Pravsgaard
Published: November 2021

It is generally believed that a successful Zika virus (ZIKV) vaccine should induce neutralizing antibodies against the ZIKV envelope (E) protein to efficiently halt viral infection. However, E-specific neutralizing antibodies have been implicated in a phenomenon called antibody-dependent enhancement, which represents an ongoing concern in the flavivirus-vaccinology field. In this report, we investigated the vaccination potential of replication-deficient adenoviral vectors encoding the ZIKV non-structural proteins 1 and 2 (NS1/NS2) and employed the strategy of linking the antigens to the MHC-II associated invariant chain (li) to improve immunogenicity and by inference, the level of protection. We demonstrated that li-linkage enhanced the production of anti-NS1 antibodies and induced an accelerated and prolonged polyfunctional CD8 T cell response in mice, which ultimately resulted in a high degree of protection against ZIKV infection of the CNS.
Predictors of COVID-19 Vaccination among Veterans Experiencing Homelessness
Authors: Balut Michelle D. , Chu Karen , Gin June L. , Dobalian Aram , Der-Martirosian Claudia
Published: November 2021

Sufficient uptake of the COVID-19 vaccine is key to slowing the spread of the coronavirus among the most vulnerable in society, including individuals experiencing homelessness. However, COVID-19 vaccination rates among the Veteran homeless population are currently unknown. This study examines the COVID-19 vaccination rate among homeless Veterans who receive care at the U.S. Department of Veterans Affairs (VA), and the factors that are associated with vaccine uptake. Using VA administrative and clinical data, bivariate and multivariate analyses were conducted to identify the sociodemographic, health-related, and healthcare and housing services utilization factors that influenced COVID-19 vaccine uptake during the first eight months of the vaccine rollout (December 2020–August 2021). Of the 83,528 Veterans experiencing homelessness included in the study, 45.8% were vaccinated for COVID-19. Non-white, older Veterans (65+), females, those who received the seasonal flu vaccine, and Veterans with multiple comorbidities and mental health conditions were more likely to be vaccinated. There was a strong association between COVID-19 vaccination and Veterans who utilized VA healthcare and housing services. VA healthcare and homeless service providers are particularly well-positioned to provide trusted information and overcome access barriers for homeless Veterans to receive the COVID-19 vaccine.
Engineering Approaches in Plant Molecular Farming for Global Health
Authors: Singh Advaita Acarya , Pillay Priyen , Tsekoa Tsepo Lebiletsa
Published: November 2021

Since the demonstration of the first plant-produced proteins of medical interest, there has been significant growth and interest in the field of plant molecular farming, with plants now being considered a viable production platform for vaccines. Despite this interest and development by a few biopharmaceutical companies, plant molecular farming is yet to be embraced by ‘big pharma’. The plant system offers a faster alternative, which is a potentially more cost-effective and scalable platform for the mass production of highly complex protein vaccines, owing to the high degree of similarity between the plant and mammalian secretory pathway. Here, we identify and address bottlenecks in the use of plants for vaccine manufacturing and discuss engineering approaches that demonstrate both the utility and versatility of the plant production system as a viable biomanufacturing platform for global health. Strategies for improving the yields and quality of plant-produced vaccines, as well as the incorporation of authentic posttranslational modifications that are essential to the functionality of these highly complex protein vaccines, will also be discussed. Case-by-case examples are considered for improving the production of functional protein-based vaccines. The combination of all these strategies provides a basis for the use of cutting-edge genome editing technology to create a general plant chassis with reduced host cell proteins, which is optimised for high-level protein production of vaccines with the correct posttranslational modifications.
Development of Inactivated FAKHRAVAC® Vaccine against SARS-CoV-2 Virus: Preclinical Study in Animal Models
Authors: Ghasemi Soheil , Naderi Saffar Kosar , Ebrahimi Firooz , Khatami Pezhman , Monazah Arina , Alizadeh Ghorban-Ali , Ettehadi Hossein-Ali , Rad Iman , Nojehdehi Shahrzad , Kehtari Mousa , Kouhkan Fatemeh , Barjasteh Hesam , Moradi Sohrab , Ghorbani Mohammad-Hosein , Khodaeipour Ali , Papizadeh Moslem , Najafi Roghayeh , Naghneh Ehsan , Sadeghi Davood , Karimi Rahjerdi Ahmad
Published: November 2021

The recent viral infection disease pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global public health crisis. Iran, as one of the countries that reported over five million infected cases by September 2021, has been concerned with the urgent development of effective vaccines against SARS-CoV-2. In this paper, we report the results of a study on potency and safety of an inactivated SARS-CoV-2 vaccine candidate (FAKHRAVAC) in a preclinical study so as to confirm its potential for further clinical evaluation. Here, we developed a pilot-scale production of FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate that induces neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and non-human primates (Rhesus macaques—RM). After obtaining ethical code of IR.IUMS.REC.1399.566, immunizations of animals were conducted by using either of three different vaccine dilutions; High (H): 10 μg/dose, Medium (M): 5 μg/dose, and Low (L): 1 μg/dose, respectively. In the process of screening for viral seeds, viral strains that resulted in the most severe clinical manifestation in patients have been isolated for vaccine development. The viral seed produced the optimal immunity against SARS-CoV-2 virus, which suggests a possible broader neutralizing ability against SARS-CoV-2 strains. The seroconversion rate at the H-, M-, and L-dose groups of all tested animals reached 100% by 28 days after immunization. These data support the eligibility of FAKHRAVAC vaccine candidate for further evaluation in a clinical trial.
Dual Corneal-Graft Rejection after mRNA Vaccine (BNT162b2) for COVID-19 during the First Six Months of Follow-Up: Case Report, State of the Art and Ethical Concerns
Authors: Nioi Matteo , d’Aloja Ernesto , Fossarello Maurizio , Napoli Pietro Emanuele
Published: November 2021

Present mass vaccination against Coronavirus Disease-19 (COVID-19) is the most widely used health policy and the most promising approach to curb the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic globally. However, new side effects are emerging from the mass vaccination not described during the experimental stages. In the present study, we discuss a case of acute corneal graft rejection, which has occurred 25 years after transplantation and 13 days after the administration of the BNT162b2 vaccine (Comirnaty, BioNTech/Pfizer), which was followed-up for a period of six months. In this period, the corneal inflammation appeared twice but was successfully managed with topical therapy and supplementation of Vitamin D. A risk of corneal graft rejection must be included in the list of potential vaccine complications, in order to inform the transplanted patient to undergo a preliminary and a follow-up ocular examination, and eventually to include corneal graft in the list of contraindications to vaccination.
Sequential Congo Red Elimination by UASB Reactor Coupled to Electrochemical Systems
Authors: Romero-Soto Itzel Celeste , García-Gómez Celestino , Álvarez-Valencia Luis Humberto , Meza-Escalante Edna Rosalba , Leyva-Soto Luis Alonso , Camacho-Ruiz Maria Angeles , Concha-Guzmán María Olga , Ulloa-Mercado Ruth Gabriela , Díaz-Tenorio Lourdes Mariana , Gortáres-Moroyoqui Pablo
Published: November 2021

Response surface methodology was investigated to determine the operational parameters on the degradation of Congo red dye (CR) and chemical oxygen demand (COD) in two electrochemical systems evaluated individually on effluent pretreated by an up-flow anaerobic sludge blanket (UASB) reactor. The UASB reactor was fed with 100 mg L−1 of CR and was operated for 12 weeks at different hydraulic residence times (HRTs) of 12 h, 10 h, and 8 h. Once stabilized at an HRT of 8 h, the effluent was collected, homogenized, and independently treated by electrooxidation (EO) and electrocoagulation (EC) cells. On both electrochemical systems, two electrode pairs were used; solid for EC (Fe and stainless-steel) and mesh electrodes for EO (Ti/PbO2 and Ti), and the effect of intensity (A), recirculation flow rate (mL min−1), and experimental time (min) was optimized on response variables. The maximum efficiencies of sequential systems for COD degradation and CR decolorization were 92.78% and 98.43% by EC and ≥99.84% and ≥99.71% by EO, respectively. Results indicate that the coupled systems can be used in textile industry wastewater treatment for the removal of dyes and the decolorized by-products.
Coastal Migration Index for Coastal Flooding Events Increased by Sea Level Rise due to Climate Change: Mexico and Cuba Case Studies
Authors: Jiménez-Hernández Sergio B. , Pérez Montero Ofelia , Meza Eustorgio , Velázquez Yunior R. , Castellanos Juan R. , Martínez-Cano Esperanza , Sosa-Pérez Felipe , Herrera Juan F. , Zielinski Seweryn , Cuker Benjamin , Oliveira Marcos , Anfuso Giorgio , Milanes Celene B.
Published: November 2021

This paper presents a coastal migration index (CMI) useful for decision-making in the current scenario of sea-level rise (SLR) due to climate change. The CMI includes coastal human population density, degree of urbanization, and coastal-flooding penetration. Quantitative and qualitative statistical techniques and the geographic information system ArcGIS View 9.0 were used. Further, a panel of fifteen international experts in coastal management issues was consulted to establish and validate the CMI. Results led to three index components based on 22 indicators. CMI was applied in the state of Tamaulipas, Mexico and in Santiago de Cuba province, Cuba. According to CMI estimates, the risk levels associated with SLR for human settlements analyzed in Mexico and Cuba were 5.3% and 11.0%, respectively. The most severely affected communities will require resettlement. Meanwhile, the CMI determined that 15.8% of the Mexican territory studied will be able to withstand the effects of SLR through the management of engineering works that will protect human settlements. The CMI determined that 79.0%, in the case of Tamaulipas, as well as 89.0% of the Cuban territory, will not require new policies or guidelines to promote conservation and protection of coastal natural resources. Lastly, the method used allowed for creation of a CMI stoplight map useful to coastal decision-makers to adopt sound management actions.
Preliminary Evaluation of the Possible Occurrence of Pesticides in Groundwater Contaminated with Nitrates—A Case Study from Southern Poland
Authors: Ślósarczyk Kinga , Witkowski Andrzej Jarosław
Published: November 2021

This paper addresses groundwater pollution and the potential presence of pesticides within the catchment areas of two reservoirs that are sources of drinking water. The two reservoirs are Goczałkowice and Kozłowa Góra, both in Southern Poland. Agricultural and rural areas dominate both catchments. Archival data showed local groundwater contamination with nitrates. This indicated the possible presence of pesticides in shallow groundwater. In total, 13 groundwater samples from shallow sandy aquifers were collected. All the samples were tested for the presence of 35 organophosphate pesticides and 28 organochlorine pesticides. Additionally, in order to determine the current groundwater conditions, physicochemical parameters were measured in the field, and water samples were subjected to analysis of their chemical composition (incl. the determination of nitrates). The research outcomes showed that pesticides were not detected above the detection limits in any of the samples. Due to variations in the persistence and degradation rates of pesticides, the occurrence of these substances in the groundwater environment and the possibility of their migration to aquifers should not be completely excluded. Natural processes and factors (e.g., sorption, biodegradation, hydrolysis and redox conditions) may gradually reduce the pesticide concentrations in groundwater. The chemical analyses revealed high concentrations of nitrates in the groundwater. This suggests the possible influence of agriculture and fertilizer application on groundwater quality; however, a proportion of NO3- ions may be connected with improper sewage management within the two catchments. The absence of pesticides in groundwater impacted by agriculture may result from processes occurring in the aquifer and the rapid degradation of these compounds due to photolysis and prevailing weather conditions. In the vicinity of dwellings, nitrates also originate from domestic wastewater. Thus, the occurrence of pesticides in groundwater contaminated with NO3 cannot always be expected.
Assessment of Water Quality in Lake Qaroun Using Ground-Based Remote Sensing Data and Artificial Neural Networks
Authors: Elsayed Salah , Ibrahim Hekmat , Hussein Hend , Elsherbiny Osama , Elmetwalli Adel H. , Moghanm Farahat S. , Ghoneim Adel M. , Danish Subhan , Datta Rahul , Gad Mohamed
Published: November 2021

Monitoring and managing water quality parameters (WQPs) in water bodies (e.g., lakes) on a large scale using sampling-point techniques is tedious, laborious, and not highly representative. Hyperspectral and data-driven technology have provided a potentially valuable tool for the precise measurement of WQPs. Therefore, the objective of this work was to integrate WQPs, derived spectral reflectance indices (published spectral reflectance indices (PSRIs)), newly two-band spectral reflectance indices (NSRIs-2b) and newly three-band spectral indices (NSRIs-3b), and artificial neural networks (ANNs) for estimating WQPs in Lake Qaroun. Shipboard cruises were conducted to collect surface water samples at 16 different sites throughout Lake Qaroun throughout a two-year study (2018 and 2019). Different WQPs, such as total nitrogen (TN), ammonium (NH4+), orthophosphate (PO43−), and chemical oxygen demand (COD), were evaluated for aquatic use. The results showed that the highest determination coefficients were recorded with the NSRIs-3b, followed by the NSRIs-2b, and then followed by the PSRIs, which produced lower R2 with all tested WQPs. The majority of NSRIs-3bs demonstrated strong significant relationships with three WQPs (TN, NH4+, and PO43−) with (R2 = 0.70 to 0.77), and a moderate relationship with COD (R2 = 0.52 to 0.64). The SRIs integrated with ANNs would be an efficient tool for estimating the investigated four WQPs in both calibration and validation datasets with acceptable accuracy. For examples, the five features of the SRIs involved in this model are of great significance for predicting TN. Its outputs showed high R2 values of 0.92 and 0.84 for calibration and validation, respectively. The ANN-PO43−VI-17 was the highest accuracy model for predicting PO43− with R2 = 0.98 and 0.89 for calibration and validation, respectively. In conclusion, this research study demonstrated that NSRIs-3b, alongside a combined approach of ANNs models and SRIs, would be an effective tool for assessing WQPs of Lake Qaroun.
Feminismos ecoterritoriales en América Latina. Entre la violencia patriarcal y extractivista y la interconexión con la naturaleza
Authors: Svampa Maristella
Published: November 2021

Desde hace décadas, en el Sur global, y muy particularmente en América Latina, las mujeres desarrollan un fuerte protagonismo en las luchas sociales y en los procesos de autoorganización colectiva vinculados al campo de los derechos humanos y a la defensa de los sectores más excluidos, a lo que se han sumado en los últimos tiempos las luchas ambientalistas. Este texto analiza algunos de los temas centrales que abordan las luchas de las mujeres en su vinculación con los movimientos y organizaciones ambientales y antiextractivistas en la región latinoamericana. Para referirme a estas luchas adopto el concepto de feminismos ecoterritoriales, en virtud de su vinculación con los movimientos ecoterritoriales y las movilizaciones de afectados socioambientales. Por un lado, el texto establece las relaciones con la perspectiva ecofeminista, en el marco de un paradigma relacional y de la cultura de los cuidados. Por otro, destaca las diferentes narrativas de los feminismos ecoterritoriales, así como el rol creciente de la violencia extractiva. El análisis se centra en las diferentes corrientes de los feminismos ecoterritoriales y el modo en que estos van configurando un espacio de geometría variable en torno a ciertos temas: Afectación ambiental y zonas de sacrificio; Agua, territorio y extractivismos; Cuerpos y territorios; Demanda de tierra y soberanía alimentaria.
Identifikasi Critical Success Factors Implementasi Media Pembelajaran Berbasis ICT Pada Jenjang PAUD
Authors: Agustini Silvia Rianti , Meisak Despita
Published: November 2021

Kemajuan teknologi membuat aspek pendidikan menjadi berubah yang mana peran teknologi sangat minim kini menjadi dominan. Untuk dapat mengantisipasi dan menghadapi transformasi besar-besaran yang akan terus terjadi maka diperlukan suatu media pembelajaran berbasis teknologi. Media pembelajaran berbasis ICT dapat digunakan sebagai media pendukung untuk pendidikan dan pengajaran yang efektif, inovatif dan menciptakan lingkungan belajar interaktif bagi guru dan juga menfasilitasi pembelajaran yang mudah bagi siswa. Penelitian ini bertujuan untuk memperoleh perspektif para stakeholder pada jenjang pendidikan anak usia dini yang kemudian dirumuskan menjadi critical success factors dalam mengimplementasikan media pembelajaran berbasis ICT bagi pendidikan anak usia dini. Pada penelitian ini penulis mengumpulkan data dengan melakukan pengamatan langsung ketempat yang menjadi objek yaitu satuan PAUD dan menyebarkan e-kuisoner yang akan diiisi oleh responden (stakeholder). Adapun alat bantu pada penelitian ini yaitu software SPSS 25 dengan memakai tabel R hasil Corrective Item Total Correlation. Dari hasil yang diperoleh berdasarkan perspektif stakeholder, faktor-faktor yang menjadi penentu keberhasilan implementasi pembelajaran (Critical Success Factors) berbasis ICT pada jenjang PAUD adalah : (1) pengawasan orang tua; (2) pelatihan bagi guru PAUD; (3) pengembangan media/konten; (4) kompetensi guru; (5) kesiapan infrastruktur; (6) interaksi guru; (7) motivasi bagi anak usia dini; (8) dampak/pengaruh yang dihasilkan oleh media pembelajaran berbasis ICT; dan (9) respon anak terhadap media berbasis ICT.
Pemodelan UML Sistem Informasi Administrasi Kependudukan Untuk Kantor Desa
Authors: Pratama Eri Bayu , Saparingga Ucok
Published: November 2021

Kantor Desa merupakan instansi yang pada umumya sekarang ini pengelolaan data penduduknya menggunakan komputer dalam kegiatan pelayanan penduduk. Hanya saja dominan dari proses atau sistem kerja yang diterapkan masih belum terintegrasi ke dalam database untuk perihal administrasi kependudukan seperti pencatatan data kelahiran, kematian dan mutasi penduduk masih menggunakan microsoft excel sebagai penginputan data penduduk. Sedangkan jika ingin mengetahui informasi penduduk juga harus melakukan pengecekan langsung di kantor, dan kebanyakan penerapan di kantor-kantor desa sistem yang ada beresiko terjadinya tindakan kesalahan oleh manusia, serta berkas kependudukan yang kemungkinan akan terjadi kehilangan atau kerusakan berkas yang berisi data penduduk, data penduduk datang, penduduk pindah, penduduk meninggal, penduduk lahir, penduduk tetap. Maka dari itu dirancang solusi dengan cara dibuatkan sebuah sistem infromasi administrasi kependudukan berbasis web dengan penerapan metodenya menggunakan pemodelan UML (Unified Modelling Language) agar mempemudah penginputan data penduduk, data penduduk meninggal dan merekap laporan dengan menggunakan jaringan internet. Dan dengan menggunakan pemodelan UML dapat menggambarkan suatu proses kerja sistem serta jelas dalam setiap proses berjalannya
Penerapan Data Mining Untuk Menganalisis Data Mahasiswa Baru STIE-GK Muara Bulian
Authors: Anas Azwar , Hartha Delima Ratumas
Published: November 2021

Data yang menumpuk dari waktu ke waktu, tidak akan memiliki nilai yang berharga jika tidak dilakukan analisis. Untuk menganalisis data historis, maka perlu digunakan metode yang tepat. Penambangan data atau dalam istilah lainnya Data Mining merupakan solusi yang tepat untuk menganalisis data historis tersebut. Tumpukan data tersebutlah yang hendak dianalisis dalam penelitian ini dengan teknik penambangan data. Tujuan dari penelitian ini adalah untuk mendapatkan pola mahasiswa baru STIE-GK Muara Bulian tahun akademik 2021/2022. Dalam penelitian ini, penulis menggunakan teknik pengayaan data mining. Adapun algoritma yang penulis gunakan dalam penambangan data ini adalah Algoritma Apriori. Sedangkan software  yang digunakan adalah Weka Data Mining. Pengujian menggunakan software data mining Weka didapatkan 10 rule terbaik. Dengan fokus pada kecamatan asal mahasiswa baru tersebut, maka kombinasi yang didapat adalah Jika mahasiswa baru tidak berasal dari Kecamatan Pemayung dan Bajubang sebanyak 1 orang, maka juga tidak berasal dari Kecamatan Maro Sebo Ulu sebanyak 73 orang dengan tingkat confidence 90%.
Shame, Stigma, HIV
Authors: Dolezal Luna
Published: November 2021

The affective climate often associated with HIV prevention and care practices is often dominated by negative emotions such as shame, fear and suspicion which arise because of HIV’s historical stigma. This article explores the experiential consequences of this affective climate and the continued stigma associated with HIV, through a focus on the experience of shame anxiety which can be under- stood as the chronic anticipation of shame or shameful exposure. Exploring first- person narratives of gay men living with HIV, the article gives an account of how shame anxiety is central to understanding how stigma causes harm, especially in experiences of chronic illnesses such as HIV. Using a philosophical framework, through phenomenology, it will be demonstrated how shame anxiety manifests in bodily lived experience through the structure of the “horizon”. The article will finish with reflections on how shame anxiety can act as a barrier to the effective delivery of health services for those with stigmatised chronic illnesses and, fur- thermore, why the experience of shame anxiety might be useful to consider when delivering health services.
Modelling and Prevention of Acute Kidney Injury through Ischemia and Reperfusion in a Combined Human Renal Proximal Tubule/Blood Vessel-on-a-Chip
Authors: Vormann Marianne K. , Tool Laura M. , Ohbuchi Masato , Gijzen Linda , van Vught Remko , Hankemeier Thomas , Kiyonaga Fumiko , Kawabe Tetsuhiro , Goto Takayuki , Fujimori Akira , Vulto Paul , Lanz Henriette L. , Tetsuka Kazuhiro
Published: November 2021

Key Points

We set up an in vitro proximal tubule model that can capture acute kidney damage after an ischemic event.

We showed the renoprotective effect of adenosine in an in vitro AKI/rIRI on-a-chip model.

We showed a robust model for AKI/rIRI that can be used for high-throughput testing.

Background

Renal ischemia/reperfusion injury (rIRI) is one of the major causes of AKI. Although animal models are suitable for investigating systemic symptoms of AKI, they are limited in translatability. Human in vitro models are crucial in giving mechanistic insights into rIRI; however, they miss out on crucial aspects such as reperfusion injury and the multitissue aspect of AKI.

Methods

We advanced the current renal proximal tubule-on-a-chip model to a coculture model with a perfused endothelial vessel separated by an extracellular matrix. The coculture was characterized for its three-dimensional structure, protein expression, and response to nephrotoxins. Then, rIRI was captured through control of oxygen levels, nutrient availability, and perfusion flow settings. Injury was quantified through morphologic assessment, caspase-3/7 activation, and cell viability.

Results

The combination of low oxygen, reduced glucose, and interrupted flow was potent to disturb the proximal tubules. This effect was strongly amplified upon reperfusion. Endothelial vessels were less sensitive to the ischemia–reperfusion parameters. Adenosine treatment showed a protective effect on the disruption of the epithelium and on the caspase-3/7 activation.

Conclusions

A human in vitro rIRI model was developed using a coculture of a proximal tubule and blood vessel on-a-chip, which was used to characterize the renoprotective effect of adenosine. The robustness of the model and assays in combination with the throughput of the platform make it ideal to advance pathophysiological research and enable the development of novel therapeutic modalities.
ПІДГОТОВКА ПЕДАГОГІЧНИХ ПРАЦІВНИКІВ У СИСТЕМІ ВИЩОЇ ОСВІТИ АВСТРАЛІЇ
Authors: Дороніна О. В. , Калашник Н. Г.
Published: November 2021

Стаття має на меті презентувати систему підготовки педагогічних працівників у системі вищої освіти Австралії. Зважаючи на глобальне старіння, в Австралії, як у всьому світі, відбувається старіння педагогічного персоналу. Разом із цим, міжнародні інституції наголошують на нестачі вчителів як світовій проблемі. У цьому контексті, підготовка нових педагогічних працівників та їх постійний професійний розвиток вважається актуальними для підтримки освітніх стандартів країни. Було визначено, що підготовка педагогічних працівників в Австралії є безперервною системою, що спрямована на підготовку всіх видів педагогічних працівників. Початкова освіта вчителів здобувається в університетах (ступінь бакалавра) на факультетах освіти, із майбутньою перспективою отримання ступенів Магістра або Доктора Освіти. Австралійські університети пропонують якісні програми підготовки вчителів. Подальший розвиток відбувається згідно з національними стандартами професійного розвитку вчителів: після отримання кваліфікації, вчителі-початківці повинні отримати акредитацію для здійснення професійної діяльності. Робиться висновок, що майбутні вчителі в Австралії отримують якісні знання та навички для подальшої роботи зі дітьми дошкільного віку, школярами, студентами, людьми з особливими потребами, людьми похилого віку. Педагогічна компетентність учителя є прямо залежною від якісної початкової освіти та подальшого професійного розвитку. Новизна отриманих результатів полягає у презентації етапів підготовки педагогічного персоналу в системі вищої освіти Австралії та висвітленні того, що це система з високими стандартами.
МЕТОДИКА ФОРМУВАННЯ КОМУНІКАТИВНОЇ КОМПЕТЕНТНОСТІ У ДІТЕЙ СТАРШОГО ДОШКІЛЬНОГО ВІКУ ІЗ МОТОРНОЮ АЛАЛІЄЮ
Authors: Баранець І. В.
Published: November 2021

У статті розкривається сутність поняття «комунікативна компетентність» у дітей із моторною алалією, яка є показником пізнавального розвитку та передумовою успішності подальшого освітнього процесу. Схарактеризовані основні складові організації корекційно-розвивальної роботи із дітьми старшого дошкільного віку із моторною алалією, що визначають ефективність процесу формування та розвитку їх комунікативно-мовленнєвої діяльності. Обґрунтовано та розроблено методику формування комунікативної компетентності у дітей старшого дошкільного віку із моторною алалією, визначено її дидактичний зміст та основні етапи впровадження, а саме: координаційно-діагностичний, корекційно-мотиваційний та репродуктивно- комунікативний. Представлені методичні рекомендації щодо її застосування. Методика формування комунікативної компетентності дітей старшого дошкільного віку із моторною алалією була побудована на основі комунікативно-діяльнісного підходу з урахуванням механізмів міжпівкульної взаємодії. Автор висвітлює ефективні шляхи стимуляції міжфункціональної взаємодії півкуль головного мозку шляхом використання технік нейролінгвістичного програмування мовленнєвого висловлювання, використанням невербальних і вербальних засобів активізації мовленнєвої діяльності.
Підкреслено особливості використання авторської методики у процесі експериментального навчання з метою формування комунікативної компетентності у дітей. Обґрунтована доцільність та ефективність застосування спеціалізованих психолого-педагогічних умов формування комунікативної компетентності у дітей досліджуваної категорії. Результати формуючого експерименту дають всі підстави стверджувати, що запропонована методика формування комунікативної компетентності у дітей старшого дошкільного віку сприяє підвищенню результативності означеного процесу. При цьому відмічено суттєві зрушення за визначеними показниками, а саме вміння проявляти ініціативу у спілкуванні, вміння підтримувати діалог, закріплення правильного використання у мовленні простих і складних речень, вміння встановлювати зв’язок слів у реченні за запитаннями, закріплення правильних мовленнєвих стереотипів, тощо.
Frullania tibetica (Frullaniaceae), a New Species from Tibet, China
Authors: Atwood John J. , Mamontov Yuriy S.
Published: November 2021

A new species, Frullania tibetica Mamontov & J. J. Atwood, is described and illustrated from Tibet, China. The species is morphologically similar to F. parvistipula Steph. in its slender leafy shoots, caducous and broadly ovate dorsal lobes, consistently inflated and galeate lobules, and obcuneate underleaves with toothed lateral margins. The new species differs in its more parallel lobule position and unequally sized lobule mouth valves on well-developed shoots, broader styli, irregularly repand gynoecial lobes, lack of gemmae on the leaf margins, and perianths with a densely tuberculate and spinose ornamentation. Based on the combination of its size, presumptively dioicous sexuality, lobe, lobule, and underleaf morphology, terminal position of the gynoecia on the stem, and trigonous, conspicuously armed perianths, F. tibetica is referable to Frullania Raddi subg. Trachycolea Spruce sect. Trachycolea (Spruce) Grolle.
Transplant Tourism and Organ Trafficking: Current Practices, Controversies and Solutions
Authors: Flaherty Gerard Thomas , Nasir Nizrull , Gormley Conor M. , Pandey Suyash
Published: November 2021

The controversial subject of transplant tourism has been neglected in the travel medicine literature. According to the Declaration of Istanbul, travel for transplantation can be regarded as transplant tourism if it involves organ trafficking and/or commercialised transplantation activities. While no registry of transplant tourism activities exists, published case series point to significant negative clinical outcomes. Adverse outcomes among donors include postoperative depression and anxiety, deterioration in health status, poor surgical wound care, and negative financial effects. Poor perioperative management, inadequate immunosuppression, blood transfusion-associated infections, antibiotic-resistant bacterial infections and invasive fungal infections, are among the most commonly reported complications in transplanted patients. Iran operates a legal and ethically regulated system of rewarded altruistic kidney donation. Travel medicine practitioners have a role to play in protecting the health of intending transplant tourists through targeted pre-travel health counselling and vaccination.
Cardiovascular Disease Among International Travellers
Authors: Mensah Daniel Oppong , Simkhada Padam
Published: November 2021

Introduction: Cardiovascular disease (CVD) is the leading cause of death among international travellers. This study aims to estimate the proportion of travellers diagnosed with CVD during international travel. Methods: A narrative synthesis of peer-reviewed literature was conducted on CVD among international travellers. Healthcare databases and sources of grey literature were searched using pre-defined criteria between February and June 2019. Two reviewers screened all the identified studies against protocol and extracted data using a piloted form. Results: Eight studies were eligible for final analysis. Four studies evaluated data from GeoSentinel Clinic databases. The number of study participants varied across studies from a minimum of 24 to a maximum of 63076. Between 0.1% and 14% of international travellers were reported or diagnosed with CVD while travelling abroad. CVD was common in male travellers as compared with female travellers. There was a lack of information on pre-existing morbidity, smoking status, obesity in all included studies. Conclusion: This review provides a first-time estimate of the proportion of international travellers with CVD while travelling overseas. Hence, preventive measures to minimize CVD risk such as sufficient exercises during long-distance flights, progressive acclimatization to altitude, wearing a face mask in polluted areas, maintaining a healthy lifestyle, and nutrition during travelling should be considered. CVD should be an important part of pre-travel health advice.
COVID-19 Electronic Registry Systems in Iran: A Review
Authors: Mousavi-Roknabadi Razieh Sadat , Safaei-Firouzabadi Hosain , Mousavi-Roknabadi Reyhaneh Sadat , Sharifi Mehrdad , Sadegh Robab , Mokdad Mojtaba
Published: November 2021

Introduction: Since the beginning of the COVID-19 epidemic in Iran, several electronic registration systems have been created to record the data of infected patients. This narrative review aimed to investigate the articles that described the COVID-19 electronic registry systems designed and implemented in Iran. Methods: In this review, four electronic databases [Medline (accessed from PubMed), Scopus, Science Direct, and Web of Science] were searched till June 22, 2020, using specific MeSH terms and related keywords in English language. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, their findings were assessed and reported. Results: Finally, four articles were enrolled, introducing four COVID-19 registries. These registries were designed and launched by Isfahan, Shiraz, Tehran, and Ilam Universities of Medical Sciences. They were different in design, the used algorithms for patients’ management, recorded data, and methods of quality assurance. Conclusion: Considering the differences between various registry systems designed for COVID-19 in Iran, it is recommended to develop a single web-based registry system by the Iran Ministry of Health and Medical Education to register and follow up the patients with COVID-19.
Biological pollution of the flora of Volyn’ Polissya in Ukraine by alien plants
Authors: VOLODYMYRETS Vitaliy , OYTSIUS Larisa , HUTSMAN Serhiy , SAVCHUK Lyubov
Published: November 2021

This study aimed to analyse biological pollution of the native flora of Volyn’ Polissya in Ukraine by alien plant species. According to the research results, 364 alien plants belonging to 228 genera and 68 families were identified in the spontaneous flora of Volyn’ Polissya. The spectrum of the most species-rich families of the alien fraction of the region’s flora includes Asteraceae, Brassicaceae, Poaceae, Rosaceae, Chenopodiaceae, Fabaceae, Lamiaceae, Solanaceae, Caryophyllaceae. As a result of the phytopollution, at least 16 families were included in the region’s flora. Four species currently in a stage of expansion were identified (Reynoutria japonica, Impatiens parviflora, Echinocystis lobata, Bidens frondosa). By origin, the species of the alien fraction of the region’s flora are dominated by the immigrants from the Mediterranean, Iranian-Turan and Atlantic-North American floristic regions. Over the past 30–50 years, at least 80 new species of alien plants have been introduced into the territory of Volyn’ Polissya. Over the past 5–7 years, the speed of the spread and naturalisation rate of species such as Quercus rubra, Asclepias syriaca, Parthenocissus quinquefolia, Prunus cerasifera, Hippophae rhamnoides, Oenothera biennis has increased. These species intensively invade the native plant communities. Phytopollution of Volyn’ Polissya is promoted by the migration of alien species from agricultural lands and escaping from cultivation. This process is also facilitated by urbanisation and the development of transport infrastructure.
Microcystis species and their toxigenic strains in phytoplankton of ten Bulgarian waterbodies
Authors: Uzunov Blagoy , Stefanova Katerina , Radkova Mariana , Descy Jean-Pierre , Gärtner Georg , Stoyneva-Gärtner Maya
Published: November 2021

The summer phytoplankton structure of ten Bulgarian waterbodies was studied by HPLC analysis of marker pigments, light microscopy (LM) and PCR amplification of mcyB and mcyE gene sequences. The aim was to detect biodiversity and spread of toxigenic strains of potential microcystin producers and the important bloom-forming genus Microcystis in particular. The screening was done in three waterbodies, where Microcystis had already been found (Lakes Ezerets and Durankulak and Reservoir Koprinka), three waterbodies from which it had not been reported (Reservoirs Shilkovtsi, Zhrebchevo, Suedinenie) and four reservoirs that were sampled for the first time (Malka Smolnitsa, Plachidol 2, Preselka, Duvanli). LM and HPLC data similarly showed that cyanoprokaryotes contributed significantly to the total phytoplankton composition (29%) and biomass (15–87%) in nine sampled waterbodies. Microcystis aeruginosa, M. natans, M. smithii, M. wesenbergii, Microcystis spp., M. cf. comperei and M. pseudofilamentosa, were identified using LM (the last two tropical species were found for the first time in the country). Despite the low contribution of Microcystis to the phytoplankton diversity (1–4 taxa per sample) and to the total phytoplankton biomass (< 0.01–0.5%), 57 toxigenic strains of this genus were revealed by PCR, most of which demonstrated high similarity with NCBI M. aeruginosa and M. wesenbergii strains.