bluuebunny/crossref_metadata_2025 huggingface dataset:
Allelopathic Potential and Active Substances from Wedelia Chinensis (Osbeck)
Authors: Hossen Kawsar , Das Krishna Rany , Okada Shun , Iwasaki Arihiro , Suenaga Kiyotake , Kato-Noguchi Hisashi
Published: November 2020

Wedelia chinensis (Asteraceae) is a wetland herb native to India, China, and Japan. It is a valuable medicinal plant recorded to have pharmaceutical properties. However, the phytotoxic potential of Wedelia chinensis has not yet been examined. Thus, we carried out this study to establish the allelopathic effects of Wedelia chinensis and to identify its phytotoxic substances. Extracts of Wedelia chinensis exhibited high inhibitory activity against the root and shoot growth of cress, alfalfa, rapeseed, lettuce, foxtail fescue, Italian ryegrass, timothy, and barnyard grass. The inhibition was varied with species and was dependent on concentrations. The extracts were separated through several purification steps, and the two effective substances were isolated and characterized as vanillic acid and gallic acid using spectral analysis. Vanillic acid and gallic acid significantly arrested the growth of cress and Italian ryegrass seedlings. The concentrations of vanillic acid and gallic acid needed for 50% inhibition (I50 values) of the seedling growth of the cress and Italian ryegrass were 0.04–15.4 and 0.45–6.6 mM, respectively. The findings suggest that vanillic acid and gallic acid may be required for the growth inhibitory activities of Wedelia chinensis.
Family and Trauma: The Autobiography of Scholarship
Authors: Wolf Diane L.
Published: November 2020

Unpeeling what is usually concealed by professional language, this essay explores the interactive relationship between my research, on the one hand, and my personal and family history, on the other. These connections are not simply uni-directional, but dynamic and interactive, evolving over time. Although some of my research questions may have paralleled my personal challenges, the Holocaust survivors I have researched also deeply affected my emotional life and personal trajectory at different times. I briefly discuss my genealogical inheritance coupled with an in-depth focus on my scholarship.
The Textual Ecology of Christine Montalbetti’s Journée américaine
Authors: McConnell Anne
Published: November 2020

Christine Montalbetti’s 2009 novel, Journée américaine, depicts a road trip, as Donovan travels from Oklahoma to visit his college friend, Tom Lee, who lives on a ranch in Colorado. While the road trip provides a basic structure for the narrative, as the text unfolds, we realize that Montalbetti’s narrator prefers to meander, rather than taking us in a linear manner towards a final destination. The narrator dives into memories, digressions, philosophical reflections, and backstories of seemingly peripheral characters in order to flesh out a complex narrative mesh. Timothy Morton’s notion of “the ecological thought” provides a compelling lens through which we can read Montalbetti’s novel, encouraging us to consider the ecological implications of a text that might not at first strike us as having anything to do with ecology. Journée américaine pushes against the outer edge of the text, spilling over into the world and also demonstrating the ways that the environment participates in the text. Montalbetti’s attention to objects, nonhuman animals, and landscapes further emphasizes how narrative does not necessarily require a human subject at the center. In the end, the narrative mesh of Journée américaine demonstrates a sprawling, complex network of relations that unfolds outward and defies boundaries.
Preoperative Aspirin Management in Redo Tetralogy of Fallot Population: Single Centre Experience
Authors: Comentale Giuseppe , Palma Gaetano , Parisi Valentina , Simeone Silvio , Pucciarelli Gianluca , Manzo Rachele , Pilato Emanuele , Giordano Raffaele
Published: November 2020

Purpose: Redo operations and preoperative antiplatelet/anticoagulant therapy can significantly increase surgical risk in congenital heart surgery. This is a retrospective study on the impact of preoperative aspirin therapy on the outcome of Tetralogy of Redo Fallot patients undergoing right ventricle outflow tract (RVOT) conduit implantation. Methods: Ten-years retrospective analysis of medical records was carried out. A total of 72 patients were divided into two groups: “Daily-on-ASA” group on daily therapy with aspirin (ASA) until 5 days from surgery and “No-Home-ASA” without it. Propensity match analysis was done in order to standardize the populations. Intraoperative and postoperative lengths were compared as well as the need for inotropic support. In addition, differences in blood transfusions and need for Fresh frozen plasma (FFP)/platelets (PLT) were analysed. Findings: Intraoperative lengths were similar between the groups. Not statistically significative differences about postoperative time to extubation (p = 0.34), ICU Stay (p = 0.31) or in-hospital stay (p = 0.36) were found. Drain loss was higher in the “Daily-on-ASA” group (407.9 ± 96.7 mL vs. 349.5 ± 84.3 mL; p = 0.03) as well as blood transfusions (372.7 ± 255.1 mL vs. 220.1 ± 130.3 mL, p = 0.02) and PLT/FFP need (217.7 ± 132.1 mL vs. 118.7 ± 147.1 mL, p = 0.01). No differences were found in postoperative complications or re-explorations for bleeding. Implications: We found no advantages in surgical times and hospital stay comparing redo patients who stopped aspirin versus those that didn’t take it in the last 6 months. However, our results suggest that redo patients undergoing RVOT conduit implantation who take daily aspirin are at higher risk of bleeding even if it is stopped 5 days before surgery.
Aortic Prosthesis-Associated MDR Pseudomonas Infections as a Diagnostic and Therapeutic Challenge
Authors: Filipe Rita , Ceia Filipa , Carvalho Ana Cláudia , Tavares Margarida , Teixeira José , Sarmento António
Published: November 2020

Endovascular prostheses are used to treat life-threatening conditions such as ruptured aortic aneurysms. Prosthetic infection cause significant morbidity and mortality, posing important diagnostic and therapeutic challenges. It is particularly difficult to diagnose and, in the era of multidrug resistance (MDR), these type of infections may become even more difficult to treat. Herein, we reported a case of a secondary prosthetic endovascular infection following repeated bacteremia episodes from a urinary source. This case illustrates an MDR Pseudomonas aeruginosa aortic infection that was difficult to diagnose with no oral antibiotic treatment options.
Formation and In Situ Treatment of High Fluoride Concentrations in Shallow Groundwater of a Semi-Arid Region: Jiaolai Basin, China
Authors: Gao Zongjun , Shi Mengjie , Zhang Hongying , Feng Jianguo , Fang Shaoyan , Cui Yechen
Published: November 2020

Fluorine is an essential nutrient, and excessive or deficient fluoride contents in water can be harmful to human health. The shallow groundwater of the Jiaolai Basin, China has a high fluoride content. This study aimed to (1) investigate the processes responsible for the formation of shallow high-fluoride groundwater (SHFGW); (2) identify appropriate methods for in situ treatment of SHFGW. A field investigation into the formation of SHFGW was conducted, and the results of experiments using soils from high-fluoride areas were examined to investigate the leaching and migration of fluoride. The results showed that the formation of SHFGW in the Jiaolai Basin is due to long-term geological and evaporation processes in the region. Stratums around and inside the basin act as the source of fluoride whereas the terrain promotes groundwater convergence. The hydrodynamic and hydrochemical conditions resulting from slow groundwater flow along with high evaporation and low rainfall all contribute to the enrichment of fluoride in groundwater. In situ treatment of SHFGW may be an effective approach to manage high SHFGW in the Jiaolai Basin. Since soil fluoride in high-fluoride areas can leach into groundwater and migrate with runoff, the construction of ditches can shorten the runoff of shallow groundwater and accelerate groundwater loss, resulting in the loss of SHFGW from high-fluoride areas through river outflow. The groundwater level will be reduced, thereby lowering the influence of evaporation on fluoride enrichment in shallow groundwater. The results of this study can act a reference for further research on in situ treatment for high-fluoride groundwater.
Experiences of LGBTIQA+ People with Disability in Healthcare and Community Services: Towards Embracing Multiple Identities
Authors: O'Shea Amie , Latham J. R. , McNair Ruth , Despott Nathan , Rose Mellem , Mountford Ruby , Frawley Patsie
Published: November 2020

Healthcare and disability support services are increasing their efforts towards inclusion and recognising the needs of different groups. This research project was conducted by academic and peer researchers (LGBTIQA+ people with disability) in Victoria, Australia using four focus groups with LGBTIQA+ people with disability. We report on two overarching themes relating to participants’ experiences of accessing health services as LGBTIQA+ people with disability: difficulties in managing multiple identities and the impacts of community services and supports. Participants described having to repeatedly ‘come out’ in a range of ways and contexts as complex and layered processes in which it was difficult to present their full range of needs and experiences to services. We also found that the role of community in promoting a sense of belonging and resilience increased capacity to manage health service use and advocacy. Services and communities aiming to be inclusive to all have the opportunity to recognise and respond to the issues faced by LGBTIQA+ people with disability as a way to pay attention to how overt and subtle practices of discrimination continue to operate despite repeated attempts at or claims of being ‘inclusive.’ Our research suggests actual inclusive, accessible services can be achieved in part through policy and practice that actively responds to the specific needs of LGBTIQA+ people with disability, in addition to LGBTIQA+ education for disability services and disability and accessibility education for LGBTIQA+ focused services. As we do in this article, we argue that this work must be done by prioritising authentic participation of LGBTIQA+ people with disability in the services and research that is about them.
Geographical Aspects of Recent Trends in Drug-Related Deaths, with a Focus on Intra-National Contextual Variation
Authors: Congdon Peter
Published: November 2020

Background. Recent worldwide estimates are of 53 million users of opioids annually, and of 585,000 drug-related deaths, of which two thirds are due to opioids. There are considerable international differences in levels of drug death rates and substance abuse. However, there are also considerable variations within countries in drug misuse, overdose rates, and in drug death rates particularly. Wide intra-national variations characterize countries where drug deaths have risen fastest in recent years, such as the US and UK. Drug deaths are an outcome of drug misuse, which can ideally be studied at a relatively low spatial scale (e.g., US counties). The research literature suggests that small area variations in drug deaths to a considerable degree reflect contextual (place-related) factors as well as individual risk factors. Methods. We consider the role of area social status, social cohesion, segregation, urbanicity, and drug supply in an ecological regression analysis of county differences in drug deaths in the US during 2015–2017. Results. The analysis of US small area data highlights a range of factors which are statistically significant in explaining differences in drug deaths, but with no risk factor having a predominant role. Comparisons with other countries where small area drug mortality data have been analyzed show differences between countries in the impact of different contextual factors, but some common themes. Conclusions. Intra-national differences in drug-related deaths are considerable, but there are significant research gaps in the evidence base for small area analysis of such deaths.
Study of Occupational Chromium, Iron, and Nickel Exposure and Amyotrophic Lateral Sclerosis in Denmark
Authors: Dickerson Aisha S. , Hansen Johnni , Gredal Ole , Weisskopf Marc G.
Published: November 2020

Studies of occupational metal exposures and amyotrophic lateral sclerosis (ALS) have focused primarily on known neurotoxicants, including lead, mercury, selenium, and cadmium. However, these exposures are often co-occurring with other lesser studied metals. We conducted a population-based case-control study with the aim of assessing associations between occupational chromium, iron, and nickel exposures and risk of ALS. We identified ALS cases in Denmark from 1982 through 2013 from the Danish National Patient Registry and matched them to 100 controls based on birth year and sex. Cumulative metal exposures were estimated using job exposure matrices applied to occupational history from the Danish Pension Fund. Although mutually adjusted odds of ALS were higher in men with chromium exposures in the third quartile (aOR = 1.24; 95% CI 0.91, 1.69) and fourth quartile (aOR = 1.19; 95% CI: 0.80, 1.76) compared to those with no exposure, differences did not reach statistical significance. We also observed higher odds of ALS in women with nickel exposures in the third quartile (aOR = 2.21; 95% CI: 1.14, 4.28), but not for the fourth quartile (aOR = 0.61; 95% CI: 0.23, 1.64). Our findings do not suggest associations between occupational exposures to these metals and ALS. However, unavoidable non-differential misclassification from the use of JEMs may have masked truly increased risk.
Spatial Optimization of Residential Care Facility Configuration Based on the Integration of Modified Immune Algorithm and GIS: A Case Study of Jing’an District in Shanghai, China
Authors: Cheng Min , Cui Xiao
Published: November 2020

As the population is aging rapidly, the irrationality of residential care facility (RCF) configuration has impacted the efficiency and quality of the aged care services so significantly that the optimization of RCF configuration is urgently required. A multi-objective spatial optimization model for the RCF configuration is developed by considering the demands of three stakeholders, including the government, the elderly, and the investor. A modified immune algorithm (MIA) is implemented to find the optimal solutions, and the geographic information system (GIS) is used to extract information on spatial relationships and visually display optimization results. Jing’an District, part of Shanghai, China, is analyzed as a case study to demonstrate the advantages of this integrated approach. The configuration rationality of existing residential care facilities (RCFs) is analyzed, and a detailed recommendation for optimization is proposed. The results indicate that the number of existing RCFs is deficient; the locations of some RCFs are unreasonable, and there is a large gap between the service supply of existing RCFs and the demands of the elderly. To fully meet the care demands of the elderly, 6 new facilities containing 1193 beds are needed to be added. In comparison with the optimization results of other algorithms, MIA is superior in terms of the calculation accuracy and convergence rate. Based on the integration of MIA and GIS, the quantity, locations, and scale of RCFs can be optimized simultaneously, effectively, and comprehensively. The optimization scheme has improved the equity and efficiency of RCF configuration, increased the profits of investors, and reduced the travel costs of the elderly. The proposed method and optimization results have reference value for policy-making and planning of RCFs as well as other public service facilities.
Daylight Saving Time and Spontaneous Deliveries: A Case–Control Study in Italy
Authors: Cappadona Rosaria , Puzzarini Sara , Farinelli Vanessa , Iannone Piergiorgio , De Giorgi Alfredo , Di Simone Emanuele , Manfredini Roberto , Verteramo Rosita , Greco Pantaleo , Rodríguez Borrego María Aurora , Fabbian Fabio , López Soto Pablo Jesús
Published: November 2020

(1) Background: Although the current literature shows that daylight saving time (DST) may play a role in human health and behavior, this topic has been poorly investigated with reference to Obstetrics. The aim of this case–control study was to evaluate whether DST may influence the number of spontaneous deliveries. (2) Methods: A low-risk pregnancy cohort with spontaneous onset of labor (n = 7415) was analyzed from a single Italian region for the period 2016–2018. Primary outcome was the number of spontaneous deliveries. Secondary outcomes were: gestational age at delivery, type and time of delivery, use of analgesia, birth weight, and 5-min Apgar at delivery. We compared the outcomes in the two weeks after DST (cases) to the two weeks before DST (controls). (3) Results: Data showed no significant difference between the number of deliveries occurring before and after DST (Chi-square = 0.546, p = 0.46). Vaginal deliveries at any gestational age showed no statistical difference between the two groups (Chi-square = 0.120, p = 0.73). There were no significant differences in the secondary outcomes, as well. (4) Conclusions: DST has neither a significant impact on the number of deliveries nor on the obstetric variables investigated by this study.
Depressive Disorders and Sleeping Disturbances—Surveys Study of 923 Participants on the Pol’and’Rock Festival, Kostrzyn, Poland 2019
Authors: Kałduńska Justyna , Skonieczna-Żydecka Karolina , Ryterska Karina , Palma Joanna , Żwierełło Wojciech , Maciejewska-Markiewicz Dominika , Czerwińska-Rogowska Maja , Wolska Anna , Stachowska Zofia , Budawski Robert , Mruk Honorata , Matyniak Damian , Popik Magdalena , Łoniewska Katarzyna , Czmielnik Marta , Fryda Aleksandra , Wronski Michal , Stachowska Ewa
Published: November 2020

Depressive disorders are common among young people and can decrease social competences and thus the quality of life. There is a relationship between the occurrence of depressive disorders and insomnia. The aim of the study was to determine the prevalence of insomnia and depressive behavior and assess the relationship between these among participants of the Pol’and’Rock Festival, Kostrzyn, Poland 2019. The study used the Athens Insomnia Scale (AIS) and the Beck Inventory II Scale (BDI-II). The study group consisted of 923 people, with the majority of women (n = 500; 54.2%). A total of 297 persons (32.2%) reported varying severity of depressive symptoms. Insomnia was observed in 261 (28.28%) respondents. Sleeping disturbances were observed more frequently in females. Persons with insomnia had a significantly higher BDI-II score. A strong positive correlation (r = 0.65) between the number of points obtained on the Beck and AIS scales was observed. Insomnia and depressive behavior are prevalent in the Polish population. Due to long-term social and economic consequences, special attention should be paid to the prevention, early detection and treatment of both disorders.
Manual Material Handling Training: The Effect of Self-Observation, Hetero-Observational and Intrinsic Feedback on Workers’ Knowledge and Behaviour
Authors: Sene-Mir Anna M. , Portell Mariona , Anguera M. Teresa , Chacón-Moscoso Salvador
Published: November 2020

This study aimed to assess the effect of systematic self-observation, hetero-observational feedback, and feedforward and intrinsic feedback (SsObserWork components) on workers’ knowledge and behaviour of a manual material handling (MMH) technique in the industrial sector. Blue-collar workers recruited from a food processing company in Catalonia (Spain) were randomized into SsObserWork (N = 31) and control (N = 30) groups. SsObserWork group members participated individually in two sessions and a three-week follow-up between sessions where they received the SsObserWork components. The control group participated individually in two sessions where they received a standard MMH training. An ad hoc instrumentcalled the MMH-SsObserWork instrument was used to assess the MMH behaviour, and an adaption of the instrument was done to assess the workers’ knowledge. Significant differences were found between groups for the identification of recommended back positions in the first session and also on comparing both sessions. However, no differences were found for the rest of the criteria. There also were significant differences between groups in the score changes of the back, knee joints, elbow joints, and interaction criterion, indicating that the SsObserWork group improved the MMH performance in these criteria (behaviour). SsObserWork intervention showed a positive effect on improving the knowledge and behaviour of the MMH technique, specifically on back posture.
Containing COVID-19 by Matching Messages on Social Distancing to Emergent Mindsets—The Case of North America
Authors: Bellissimo Nick , Gabay Gillie , Gere Attila , Kucab Michaela , Moskowitz Howard
Published: November 2020

Public compliance with social distancing is key to containing COVID-19, yet there is a lack of knowledge on which communication ‘messages’ drive compliance. Respondents (224 Canadians and Americans) rated combinations of messages about compliance, systematically varied by an experimental design. Independent variables were perceived risk; the agent communicating the policy; specific social distancing practices; and methods to enforce compliance. Response patterns to each message suggest three mindset segments in each country reflecting how a person thinks. Two mindsets, the same in Canada and the US, were ‘tell me exactly what to do,’ and ‘pandemic onlookers.’ The third was ‘bow to authority’ in Canada, and ‘tell me how’ in the US. Each mindset showed different messages strongly driving compliance. To effectively use messaging about compliance, policy makers may assign any person or group in the population to the appropriate mindset segment by using a Personal Viewpoint Identifier that we developed.
The Food Bank of Madrid: A Linear Model for Optimal Nutrition
Authors: Castañón Rosendo , Campos Fco. Alberto , Doménech Martínez Salvador , Villar José
Published: November 2020

This work proposes a mathematical linear programming model that addresses the food provisioning problem of the food bank of Madrid. It aims to determine the most appropriate weekly decisions to meet the macro-nutritional requirements of the beneficiaries of this social service, by minimizing the total cost considering third-party donations. The model has been applied to a realistic case study considering a sociological structure of beneficiaries categorized by age and gender and representing the first decile of incomes of the Spanish population. The demand of macronutrients is satisfied by means of nine different groups of food, used to provide some level of variability in the consumption patterns of the beneficiaries. The results provide insight on cost-cutting opportunities related to centralizing the decision-making process, indicating a 10% reduction both in provisioning costs and food quantities. This suggests that the proposed model might serve as a tool for designing new strategies for the provisioning or evaluation of economic and social support policies for the food bank of Madrid.
Is Quarantine for COVID-19 Pandemic Associated with Psychological Burden in Primary Ciliary Dyskinesia?
Authors: Riccio Maria Pia , Borrelli Melissa , Fioretti Maria Teresa , Del Bene Margherita , Bravaccio Carmela , Poeta Marco , Santamaria Francesca
Published: November 2020

Background: Information on psychological impact of COVID-19 quarantine in primary ciliary dyskinesia (PCD), a chronic disorder with recurrent pulmonary exacerbations, is lacking. Psychological well-being was prospectively assessed during COVID-19 lockdown in Italy in a PCD population. Methods: we recruited 27 PCD patients and 27 healthy controls. To assess psychological well-being, psychological general well-being index and parenting stress index-short questionnaires were administered to participants ≥15 years-old and to mothers of participants <15 years-old, respectively. The PCD exacerbations since outbreak onset and frequency of quarantine weekly chest physiotherapy were compared to the same period of 2019. Outcomes: 70% of PCD mothers and 90% of PCD patients did not show parental stress levels or distress levels, respectively, and these groups showed no significant difference in stress compared to controls. The PCD pulmonary exacerbations occurred less frequently and weekly chest physiotherapy sessions significantly increased compared to the same period during 2019 (p < 0.05). Interpretation: During COVID-19 quarantine, a PCD population showed psychological well-being. Low exacerbation rate, explained by lower infectious exposure or improved compliance to chest physiotherapy, likely contributed to psychological well-being. Evaluating psychological burden and parental stress is a valuable tool for measuring the emotional impact of PCD and improving PCD medical care.
Heat Stress and Thermal Perception amongst Healthcare Workers during the COVID-19 Pandemic in India and Singapore
Authors: Lee Jimmy , Venugopal Vidhya , Latha P K , Alhadad Sharifah Badriyah , Leow Clarence Hong Wei , Goh Nicholas Yong De , Tan Esther , Kjellstrom Tord , Morabito Marco , Lee Jason Kai Wei
Published: November 2020

The need for healthcare workers (HCWs) to wear personal protective equipment (PPE) during the coronavirus disease 2019 (COVID-19) pandemic heightens their risk of thermal stress. We assessed the knowledge, attitudes, and practices of HCWs from India and Singapore regarding PPE usage and heat stress when performing treatment and care activities. One hundred sixty-five HCWs from India (n = 110) and Singapore (n = 55) participated in a survey. Thirty-seven HCWs from Singapore provided thermal comfort ratings before and after ice slurry ingestion. Differences in responses between India and Singapore HCWs were compared. A p-value cut-off of 0.05 depicted statistical significance. Median wet-bulb globe temperature was higher in India (30.2 °C (interquartile range [IQR] 29.1–31.8 °C)) than in Singapore (22.0 °C (IQR 18.8–24.8 °C)) (p < 0.001). Respondents from both countries reported thirst (n = 144, 87%), excessive sweating (n = 145, 88%), exhaustion (n = 128, 78%), and desire to go to comfort zones (n = 136, 84%). In Singapore, reports of air-conditioning at worksites (n = 34, 62%), dedicated rest area availability (n = 55, 100%), and PPE removal during breaks (n = 54, 98.2%) were higher than in India (n = 27, 25%; n = 46, 42%; and n = 66, 60%, respectively) (p < 0.001). Median thermal comfort rating improved from 2 (IQR 1–2) to 0 (IQR 0–1) after ice slurry ingestion in Singapore (p < 0.001). HCWs are cognizant of the effects of heat stress but might not adopt best practices due to various constraints. Thermal stress management is better in Singapore than in India. Ice slurry ingestion is shown to be practical and effective in promoting thermal comfort. Adverse effects of heat stress on productivity and judgment of HCWs warrant further investigation.
Feeling Anxious amid the COVID-19 Pandemic: Psychosocial Correlates of Anxiety Symptoms among Filipina Domestic Helpers in Hong Kong
Authors: C. Y. Yeung Nelson , Huang Bishan , Lau Christine Y. K. , Lau Joseph T. F.
Published: November 2020

The COVID-19 pandemic negatively impacts psychological well-being (e.g., anxiety symptoms) among the general population of Hong Kong and migrant Filipina domestic helpers (FDHs). Having to live with the employers by law, FDHs’ working environment might affect their well-being during COVID-19 (e.g., household crowdedness/size, insufficiency of protective equipment against COVID-19, increased workload). Research has suggested that coping resources (e.g., social support, COVID-19-related information literacy) and COVID-19-specific worries are associated with people’s well-being during COVID-19. This study examined the psychosocial correlates of probable anxiety among FDHs in Hong Kong amid the COVID-19 pandemic. By purposive sampling, FDHs (n = 295) were recruited and invited to complete a cross-sectional survey. Participants’ working environment (crowdedness, household size), COVID-19 job arrangements (workload, provision of protective equipment), coping resources (social support, COVID-19 information literacy), COVID-19-specific worries (contracting COVID-19, getting fired if contracting COVID-19), and anxiety symptoms were measured. Multivariate regression results showed that the insufficiency of protective equipment (OR = 1.58, 95%CI: 1.18, 2.11), increased workload (OR = 1.51, 95%CI: 1.02, 2.25), and worries about being fired if getting COVID-19 (OR = 1.32, 95%CI: 1.04, 1.68) were significantly associated with probable anxiety. This was one of the earliest studies to indicate that job arrangements and COVID-19-specific worries significantly contributed to FDHs’ anxiety symptoms. Our findings shed light on the importance of addressing employment-related rights and pandemic-specific worries through interventions among FDHs in Hong Kong during pandemic situations.
Maitjara Wangkanyi: Insights from an Ethnographic Study of Food Practices of Households in Remote Australian Aboriginal Communities
Authors: Bryce Suzanne , Scales Inawantji , Herron Lisa-Maree , Wigginton Britta , Lewis Meron , Lee Amanda ,   Ngaanyatjarra Pitjantjatjara Yankunytjatjara (NPY) Women’s Council
Published: November 2020

Many historical, environmental, socioeconomic, political, commercial, and geographic factors underscore the food insecurity and poor diet-related health experienced by Aboriginal people in Australia. Yet, there has been little exploration of Aboriginal food practices or perspectives on food choice recently. This study, with 13 households in remote communities on the Anangu Pitjantjatjara Yankunytjatjara (APY) Lands, fills this gap using ethnographic and Indigenist methods. Results highlight Anangu resourcefulness, securing food despite poverty and adversity, and provide unique insights into factors influencing the three major types and range of dietary patterns identified. These factors include household economic cycles and budgeting challenges; overcrowding and family structures, mobility and ‘organization’; available food storage, preparation and cooking infrastructure; and familiarity and convenience. Structural and systemic reform, respecting Aboriginal leadership, is required to improve food security.
Model Calculations of Aerosol Transmission and Infection Risk of COVID-19 in Indoor Environments
Authors: Lelieveld Jos , Helleis Frank , Borrmann Stephan , Cheng Yafang , Drewnick Frank , Haug Gerald , Klimach Thomas , Sciare Jean , Su Hang , Pöschl Ulrich
Published: November 2020

The role of aerosolized SARS-CoV-2 viruses in airborne transmission of COVID-19 has been debated. The aerosols are transmitted through breathing and vocalization by infectious subjects. Some authors state that this represents the dominant route of spreading, while others dismiss the option. Here we present an adjustable algorithm to estimate the infection risk for different indoor environments, constrained by published data of human aerosol emissions, SARS-CoV-2 viral loads, infective dose and other parameters. We evaluate typical indoor settings such as an office, a classroom, choir practice, and a reception/party. Our results suggest that aerosols from highly infective subjects can effectively transmit COVID-19 in indoor environments. This “highly infective” category represents approximately 20% of the patients who tested positive for SARS-CoV-2. We find that “super infective” subjects, representing the top 5–10% of subjects with a positive test, plus an unknown fraction of less—but still highly infective, high aerosol-emitting subjects—may cause COVID-19 clusters (>10 infections). In general, active room ventilation and the ubiquitous wearing of face masks (i.e., by all subjects) may reduce the individual infection risk by a factor of five to ten, similar to high-volume, high-efficiency particulate air (HEPA) filtering. A particularly effective mitigation measure is the use of high-quality masks, which can drastically reduce the indoor infection risk through aerosols.
A Review of the Applications, Environmental Release, and Remediation Technologies of Per- and Polyfluoroalkyl Substances
Authors: Meegoda Jay N. , Kewalramani Jitendra A. , Li Brian , Marsh Richard W.
Published: November 2020

Per- and polyfluoroalkyl substances (PFAS) are pollutants that have demonstrated a high level of environmental persistence and are very difficult to remediate. As the body of literature on their environmental effects has increased, so has regulatory and research scrutiny. The widespread usage of PFAS in industrial applications and consumer products, complicated by their environmental release, mobility, fate, and transport, have resulted in multiple exposure routes for humans. Furthermore, low screening levels and stringent regulatory standards that vary by state introduce considerable uncertainty and potential costs in the environmental management of PFAS. The recalcitrant nature of PFAS render their removal difficult, but existing and emerging technologies can be leveraged to destroy or sequester PFAS in a variety of environmental matrices. Additionally, new research on PFAS remediation technologies has emerged to address the efficiency, costs, and other shortcomings of existing remediation methods. Further research on the impact of field parameters such as secondary water quality effects, the presence of co-contaminants and emerging PFAS, reaction mechanisms, defluorination yields, and the decomposition products of treatment technologies is needed to fully evaluate these emerging technologies, and industry attention should focus on treatment train approaches to improve efficiency and reduce the cost of treatment.
Who Benefits from the Fixed Copayment of Medical and Pharmaceutical Expenditure among the Korean Elderly?
Authors: Park Eunja , Choi Sookja
Published: November 2020

The Korean National Health Insurance system imposes a 30% coinsurance for outpatient medical care and prescription drugs; however, at the age of 65, the coinsurance model changes to a copayment model that offers lower fees for the elderly. Thus, this study aimed to investigate the influence of the copayment model for outpatient visits and prescription drugs on healthcare utilization among the Korean elderly. We compared total outpatient visits, total prescriptions, and out-of-pocket expenses between a case group with copayment reduction (65 years or older) and a control group without any reduction (64 years or younger). We obtained secondary data collected from seven waves of the Korea Health Panel Survey (2010–2016). Outpatient visits increased exclusively in the case group among those with lower income. After adjusting for covariates, the results of the difference-in-differences analysis showed that, compared to the control group, there was a significant increase in outpatient visits among individuals with lower income in the case group. Our study shows that cost sharing changes affect Korean patients with different income levels in different ways.
Does Dietary Diversity Reduce the Risk of Obesity? Empirical Evidence from Rural School Children in China
Authors: Tao Chang , Zhao Qiran , Glauben Thomas , Ren Yanjun
Published: November 2020

Childhood and adolescence overweight and obesity have implications for both health consequences and economic burden. Although it has been an emerging public health problem for primary school children in rural China and the importance of the diet–health link has been stressed for many years, rigorous analysis of the dietary diversity and obesity among children is rare. To clarify this issue, this study provides a better understanding of the functional linkage between dietary diversity and obesity by analyzing data from nearly 8500 rural primary students (aged from 10 to 13 years old) covering three provinces in China. Our estimation results show that there is a significantly negative correlation between dietary diversity and the probability of being overweight among primary students. In particular, for subgroups with higher dietary diversity, the negative correlation between dietary diversity and the incidence of overweight or obesity is stronger, and the absolute value of the coefficient is greater. The results also suggest that the increase in the consumption frequency of all dietary categories can significantly lead to a lower proportion of overweight. Thus, we conclude that higher dietary diversity can help to lower the risk of overweight and obesity among primary school children, presumably through increasing the daily frequency of food intakes and developing a more diverse dietary pattern.
Effectiveness of School Site Decisions on Land Use Policy in the Planning Process
Authors: Baser Volkan
Published: November 2020

The school site is a key element of the educational process, as children spend a large amount of their time there. Schools that are well-located, designed within a systematic plan, safe, and operated in an efficient manner contribute to the development of society. Since land is a scarce resource, optimal land use is a spatial necessity. In developed societies, these usage preferences are planned and presented to decision-makers according to criteria, such as distance, slope, population, land use, etc., that are related to industry and agriculture. Suitable investment areas are often not mapped in development plans. This deficiency arising from planning also appears in the determination of school site locations. In this research, a real case study was conducted to solve the problem presented. The most used school sites’ criteria were determined from the literature and those criteria were weighted with the analytical hierarchy process method. A cost–surface map of the study region was produced and associated with the implementary development plan. It was obtained from the cost surface map that suitable school sites are planned for urban, commercial, or different purposes. Additionally, possible locations for the school site in the region were determined and mapped for a future planning purpose, and the sizes of existing school campus sites in the region were analyzed. When existing campus areas were evaluated according to the number of school students, we found that only 40% of the schools were suitable. As one of the major findings, 210 possible school sites with a size of at least 2 ha were determined and mapped in Giresun, Turkey. For these reasons, clearly identifying the investment areas and transferring them to the plans is essential for sustainability.
SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis
Authors: Jin Yi , Tan Yanjie , Zhao Pengxiang , Ren Zhuqing
Published: November 2020

Lipid homeostasis is essential for normal cell physiology. Generally, lipids are stored in a lipid droplet (LD), a ubiquitous organelle consisting of a neutral lipid core and a single layer of phospholipid membrane. It is thought that LDs are generated from the endoplasmic reticulum and then released into the cytosol. Recent studies indicate that LDs can exist in the nucleus, where they play an important role in the maintenance of cell phospholipid homeostasis. However, the details of nuclear lipid droplet (nLD) generation have not yet been clearly characterized. SEIPIN is a nonenzymatic protein encoded by the Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene. It is associated with lipodystrophy diseases. Many recent studies have indicated that SEIPIN is essential for LDs generation. Here, we review much of this research in an attempt to explain the role of SEIPIN in nLD generation. From an integrative perspective, we conclude by proposing a theoretical model to explain how SEIPIN might participate in maintaining homeostasis of lipid metabolism.
Polycystic Ovary Syndrome: A Brain Disorder Characterized by Eating Problems Originating during Puberty and Adolescence
Authors: Steegers-Theunissen Régine P. M. , Wiegel Rosalieke E. , Jansen Pauline W. , Laven Joop S. E. , Sinclair Kevin D.
Published: November 2020

Polycystic ovary syndrome (PCOS) is an endocrine condition associated with reproductive and psychiatric disorders, and with obesity. Eating disorders, such as bulimia and recurrent dieting, are also linked to PCOS. They can lead to the epigenetic dysregulation of the hypothalamic–pituitary–gonadal (HPG) axis, thereby impacting on ovarian folliculogenesis. We postulate that PCOS is induced by psychological distress and episodes of overeating and/or dieting during puberty and adolescence, when body dissatisfaction and emotional distress are often present. We propose that upregulated activation of the central HPG axis during this period can be epigenetically altered by psychological stressors and by bulimia/recurrent dieting, which are common during adolescence and which can lead to PCOS. This hypothesis is based on events that occur during a largely neglected stage of female reproductive development. To date, most research into the origins of PCOS has focused on the prenatal induction of this disorder, particularly in utero androgenization and the role of anti-Müllerian hormone. Establishing causality in our peripubertal model requires prospective cohort studies from infancy. Mechanistic studies should consider the role of the gut microbiota in addition to the epigenetic regulation of (neuro) hormones. Finally, clinicians should consider the importance of underlying chronic psychological distress and eating disorders in PCOS.
HIV-1 Tat Dysregulates the Hypothalamic-Pituitary-Adrenal Stress Axis and Potentiates Oxycodone-Mediated Psychomotor and Anxiety-Like Behavior of Male Mice
Authors: Salahuddin Mohammed F. , Mahdi Fakhri , Paris Jason J.
Published: November 2020

Human immunodeficiency virus (HIV) is associated with co-morbid affective and stress-sensitive neuropsychiatric disorders that may be related to dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis. The HPA axis is perturbed in up to 46% of HIV patients, but the mechanisms are not known. The neurotoxic HIV-1 regulatory protein, trans-activator of transcription (Tat), may contribute. We hypothesized that HPA dysregulation may contribute to Tat-mediated interactions with oxycodone, a clinically-used opioid often prescribed to HIV patients. In transgenic male mice, Tat expression produced significantly higher basal corticosterone levels with adrenal insufficiency in response to a natural stressor or pharmacological blockade of HPA feedback, recapitulating the clinical phenotype. On acute exposure, HIV-1 Tat interacted with oxycodone to potentiate psychomotor and anxiety like-behavior in an open field and light-dark transition tasks, whereas repeated exposure sensitized stress-related psychomotor behavior and the HPA stress response. Pharmacological blockade of glucocorticoid receptors (GR) partially-restored the stress response and decreased oxycodone-mediated psychomotor behavior in Tat-expressing mice, implicating GR in these effects. Blocking corticotrophin-releasing factor (CRF) receptors reduced anxiety-like behavior in mice that were exposed to oxycodone. Together, these effects support the notion that Tat exposure can dysregulate the HPA axis, potentially raising vulnerability to stress-related substance use and affective disorders.
Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor
Authors: Sotnikova Tatyana D. , Efimova Evgeniya V. , Gainetdinov Raul R.
Published: November 2020

Dopamine transporter knockout (DATk) mice are known to demonstrate profound hyperactivity concurrent with elevated (5-fold) extracellular dopamine in the basal ganglia. At the same time, heterozygous DAT mice (DATh) demonstrate a 2-fold increase in dopamine levels yet only a marginal elevation in locomotor activity level. Another model of dopaminergic hyperactivity is the D3 dopamine receptor knockout (D3k) mice, which present only a modest hyperactivity phenotype, predominately manifested as stereotypical behaviors. In the D3k mice, the hyperactivity is also correlated with elevated extracellular dopamine levels (2-fold) in the basal ganglia. Cross-breeding was used to evaluate the functional consequences of the deletion of both genes. In the heterozygous DAT mice, inactivation of the D3R gene (DATh/D3k) resulted in significant hyperactivity and further elevation of striatal extracellular dopamine above levels observed in respective single mutant mice. The decreased weight of DATk mice was evident regardless of the D3 dopamine receptor genotype. In contrast, measures of thermoregulation revealed that the marked hypothermia of DATk mice (−2 °C) was reversed in double knockout mice. Thus, the extracellular dopamine levels elevated by prolonging uptake could be elevated even further by eliminating the D3 receptor. These data also suggest that the hypothermia observed in DATk mice may be mediated through D3 receptors.
Intrathecal Inflammation in Progressive Multiple Sclerosis
Authors: Monaco Salvatore , Nicholas Richard , Reynolds Richard , Magliozzi Roberta
Published: November 2020

Progressive forms of multiple sclerosis (MS) are associated with chronic demyelination, axonal loss, neurodegeneration, cortical and deep gray matter damage, and atrophy. These changes are strictly associated with compartmentalized sustained inflammation within the brain parenchyma, the leptomeninges, and the cerebrospinal fluid. In progressive MS, molecular mechanisms underlying active demyelination differ from processes that drive neurodegeneration at cortical and subcortical locations. The widespread pattern of neurodegeneration is consistent with mechanisms associated with the inflammatory molecular load of the cerebrospinal fluid. This is at variance with gray matter demyelination that typically occurs at focal subpial sites, in the proximity of ectopic meningeal lymphoid follicles. Accordingly, it is possible that variations in the extent and location of neurodegeneration may be accounted for by individual differences in CSF flow, and by the composition of soluble inflammatory factors and their clearance. In addition, “double hit” damage may occur at sites allowing a bidirectional exchange between interstitial fluid and CSF, such as the Virchow–Robin spaces and the periventricular ependymal barrier. An important aspect of CSF inflammation and deep gray matter damage in MS involves dysfunction of the blood–cerebrospinal fluid barrier and inflammation in the choroid plexus. Here, we provide a comprehensive review on the role of intrathecal inflammation compartmentalized to CNS and non-neural tissues in progressive MS.
Neuropeptide Y as Alternative Pharmacotherapy for Antidepressant-Resistant Social Fear
Authors: Kornhuber Johannes , Zoicas Iulia
Published: November 2020

In many social anxiety disorder (SAD) patients, the efficacy of antidepressant therapy is unsatisfactory. Here, we investigated whether mice deficient for the lysosomal glycoprotein acid sphingomyelinase (ASM−/−) represent an appropriate tool to study antidepressant-resistant social fear. We also investigated whether neuropeptide Y (NPY) reduces this antidepressant-resistant social fear in ASM−/− mice, given that NPY reduced social fear in a mouse model of SAD, namely social fear conditioning (SFC). We show that neither chronic paroxetine nor chronic amitriptyline administration via drinking water were successful in reducing SFC-induced social fear in ASM−/− mice, while the same treatment reduced social fear in ASM+/− mice and completely reversed social fear in ASM+/+ mice. This indicates that the antidepressants paroxetine and amitriptyline reduce social fear via the ASM-ceramide system and that ASM−/− mice represent an appropriate tool to study antidepressant-resistant social fear. The intracerebroventricular administration of NPY, on the other hand, reduced social fear in ASM−/− mice, suggesting that NPY might represent an alternative pharmacotherapy for antidepressant-resistant social fear. These results suggest that medication strategies aimed at increasing brain NPY concentrations might improve symptoms of social fear in SAD patients who fail to respond to antidepressant treatments.