bluuebunny/crossref_metadata_2025 huggingface dataset:
Subclinical gastrointestinal mucosal lesions occur in dogs with intrahepatic portosystemic shunts independent of percutaneous transvenous coil embolization
Authors: Gibson Erin A. , Culp William T. N. , Hardy Brian T. , Giuffrida Michelle A. , Balsa Ingrid M. , Mayhew Phillip , Marks Stanley L.
Published: February 2025

OBJECTIVE

To determine the prevalence and severity of gastrointestinal mucosal lesions in dogs with intrahepatic portosystemic shunts (IHPSS), and to compare the prevalence and severity of gastrointestinal mucosal lesions in dogs with IHPSS before and after treatment with percutaneous transvenous coil embolization (PTCE) based on capsule endoscopy (CE).

METHODS

A prospective clinical trial was performed from June 1, 2020, to March 1, 2022. Ten client-owned dogs diagnosed with IHPSS by use of CT angiography were included. Dogs were administered a capsule endoscopy device prior to and 1 month following PTCE. Outcomes compared before and after PTCE included gastrointestinal mucosal lesions as observed via CE, serum biochemistry changes, and client-reported clinical metrology data.

RESULTS

All dogs underwent pre- and postprocedure CE without adverse events. Six and 5 dogs each had gastric and intestinal mucosal lesions on pre-PTCE CE images, whereas 8 and 4 dogs each had gastric and intestinal mucosal lesions after PTCE. Six of 7 dogs with pre-PTCE lesions had post-PTCE lesions, and 3 of 4 dogs without pre-PTCE lesions had post-PTCE lesions. There was no significant difference in mucosal severity scores of gastric or small intestinal segments before PTCE or 1 month after PTCE. There was significant improvement in owner-reported symptom assessment scores 1 month after PTCE compared to before PTCE.

CONCLUSIONS

Abnormalities of the gastric and small intestinal mucosal surface were common on the basis of CE images within this population of dogs with IHPSS. Severity of mucosal lesions was not associated with PTCE treatment short-term.

CLINICAL RELEVANCE

Dogs with IHPSS prior to and following PTCE may require ongoing management for subclinical gastrointestinal lesions. Further investigation to understand clinical relevance of these lesions is indicated.
The impacts of thermal stress on dairy cattle physiology, metabolism, health, and performance: a comprehensive review
Authors: Soliman Soliman M. , El-Saadony Mohamed T. , Saad Ahmed , Mosa Walid F.A. , Khalil Fatma Mohamed Ameen , Ahmed Ahmed Ezzat , Mohammed Dina Mostafa , Manasar Mayadah M. , Farag Mayada R. , Alagawany Mahmoud , Salem Heba M.
Published: February 2025

Climate change is becoming a global issue, with important implications for dairy cow performance and well-being. It is distinguished by a gradual rise in universal temperature and the risk of extreme weather occurrences. Studies have shown that heat stress (HS) impacts many biological processes that can have significant economic issues. Due to their elevated metabolic rate, cows are mostly liable to HS, which negatively affects immune function, particularly cell-mediated immune response, and subsequent reduced production performance and inferior immunity, which leads to elevated susceptibility to disease, increased incidence of intramammary infections, and an elevated somatic cell count, as well as calf mortality, particularly during the summer season. Furthermore, dry cows subjected to HS had reduced immunoglobulin levels after vaccination, although this impact fades with cooling after parturition. On the other hand, cows subjected to HS while dry demonstrate carryover impacts on the innate arm of the immunity in early lactation, resulting in losses. Heat mitigation technologies are cost-effective and necessary for sustaining milk production and the dairy farm’s profitability. Furthermore, a check of present HS mitigation measures is required to understand better and identify acceptable abatement plans for future stress management.
PERAN CITRA MEREK MEMEDIASI PENGARUH KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN PADA KEDAI KOPI JENAR DENPASAR
Authors: Putra Kusuma Putu Indrayana , Sukaatmadja I Putu Gde
Published: February 2025

The purpose of this study was to determine the role of brand image in mediating the effect of product quality on coffee purchasing decisions. The research location was conducted in Denpasar City on 100 respondents who were selected by purposive sampling method. The data analysis technique used is path analysis. The results showed that product quality had a positive and significant effect on purchasing decisions at the Jenar Coffee Shop in Denpasar City. This means that the better the quality of the products owned by the company, the stronger the purchasing decisions made by consumers. Product quality has a positive and significant effect on brand image at the Jenar Coffee Shop in Denpasar City. This means that the better the quality of the products owned by the company, the better the brand image produced by the company in the minds of consumers. Brand image has a positive and significant effect on purchasing decisions at the Jenar Coffee Shop in Denpasar City. This means that when the company is able to create a good brand image, the more confident the consumer's purchasing decisions will be. Brand image is able to fully mediate the influence of product quality on purchasing decisions at Jenar Coffee Shop in Denpasar City.
Keywords: Purchasing decisions; Brand image; Product quality
ANALISIS PERBANDINGAN KINERJA KEUANGAN SEBELUM, SESUDAH MERGER DAN AKUISISI PADA PERBANKAN DI BURSA EFEK INDONESIA
Authors: Meilani Ni Putu Rina , Dana I Made
Published: February 2025

A merger is a merger of two companies while an acquisition is a takeover of a company. Mergers and acquisitions decisions have a major influence on the improvement and improvement of the company's condition. Mergers and acquisitions do not always have a positive impact on a company's financial performance. This study aims to analyze the differences in performance before and after mergers and acquisitions in banks on the Indonesia Stock Exchange. Measurement of financial performance using five ratios, namely Capital Adequacy Ratio (CAR), Current Ratio (CR), Return on asset (ROA), Debt to Equity Ratio (DER), and Total Aset Turnover (TATO). The sampling technique was purposive sampling. The data analysis technique used was the Paired Sample T-Test and the Wilcoxon Signed Rank Test. Based on the results of the analysis it was found that there were no significant differences in the financial performance of CAR, CR, ROA, DER, and TATO before and after mergers and acquisitions.
Keywords: Mergers and Acquisitions; Financial Performance; CAR; CR; ROA
PERAN KEPUASAN PELANGGAN MEMEDIASI PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS PELANGGAN
Authors: Dharma I Made Satya Yoga , Aksari Ni Made Asti
Published: February 2025

The purpose of this study was to examine and explain the role of customer satisfaction in mediating the effect of service quality on customer loyalty. This research was conducted in the work area of CV Sejuk Bali Nirmala. The method used in determining the sample is probability sampling with a saturated sampling determination of 110 respondents. Data collection was carried out using a questionnaire. The data analysis technique used to answer the proposed hypothesis is path analysis and mediation testing using the Sobel test. Based on the results of the analysis, it can be concluded that service quality has a positive and significant effect on customer satisfaction and customer loyalty, customer satisfaction has a positive and significant effect on customer loyalty, and customer satisfaction is able to mediate service quality on customer loyalty. CV Sejuk Bali Nirmala is expected to prioritize customer convenience, equip employees on how to serve customers and evaluate employee performance. Theoretically, this study provides an understanding that the level of service quality and customer satisfaction makes a special contribution to customer loyalty.
Keywords: Customer loyalty, Customer satisfaction, Service quality
Pengembangan Multimedia Interaktif Berbasis Android pada Materi Struktur Bumi dan Perkembangannya
Authors: Ahmad Luluk Nafisah
Published: February 2025

Multimedia interaktif merupakan suatu tampilan agar tampilannya dapat menginformasikan pesan dan memiliki interaktivitas kepada penggunanya. Multimedia interaktif dikembangkan menggunakan Microsoft Power Point, I-spring dan Website 2 Apk. Penelitian ini bertujuan untuk mengembangkan serta menguji kelayakan multimedia interaktif berbasis android pada materi struktur bumi dan perkembangannya. Model pengembangan yang digunakan adalah model ADDIE. pada peserta didik kelas VIII SMP Negeri 4 Bangkalan. Instrumen uji coba yang digunakan adalah lembar validasi ahli media, ahli materi, dan angket respons peserta didik. Hasil data validitas berdasarkan aspek media memperoleh sebesar 0,98 dan reliabilitas sebesar 98%  sedangkan berdasarkan aspek materi memperoleh validitas sebesar 0,96 dan reliabilitas sebesar 98%. Hasil respons peserta didik terhadap multimedia interaktif berbasis android memperoleh sebesar 88% pada uji peroranga, 85% pada uji kelompok kecil, dan 77% pada uji kelompok besar. Hal tersebut menunjukkan bahwa multimedia interaktif berbasis android sangat layak digunakan dalam proses pembelajaran.
Keefektifan Penerapan Model Pembelajaran Problem Based Learning terhadap Hasil Belajar Materi Bioteknologi pada Kelas IX SMP
Authors: Baehaqi Ibnu Baehaqi , Agustini Ferina , Hayat Muhammad Syaipul , Rachmawati Febrina
Published: February 2025

Penelitian ini bertujuan untuk mengetahui keefektifan penerapan model pembelajaran problem based learning terhadap hasil belajar materi bioteknologi  kelas IX di SMP Negeri 2 Semarang. Penelitian ini dilakukan 31 Januari 2023 di SMP N 2 Semarang. Sampel penelitian ini yaitu kelas IXD yang berjumlah 32 peserta didik. Penelitian ini merupakan penelitian kuantitatif dengan desain pra-eksperimen (One Group Prestest and Posttest Desain) dengan menghitung selisih antara posttest sebagai kemampuan akhir dikurangi pretest sebagai kemampuan awal. Hasil penelitian hasil belajar kognitif menunjukkan bahwa rata-rata nilai pretest sebesar 36,25 dan rata-rata nilai posttest sebesar 79,38 dengan ketuntasan belajar klasikal mencapai 81,20% dan N-gain sebesar 67% dengan kategori sedang. Berdasarkan penelitian dapat disimpulkan bahwa cukup efektif penerapan model pembelajaran problem based learning terhadap peningkatan hasil belajar peserta didik pada materi bioteknologi kelas IXD di SMP N 2 Semarang.
Surface triggering receptor expressed on myeloid cells-1 (sTREM1) in critically ill children: a prospective observational controlled study
Authors: Rashad Fouda Elsaeed , Abd Elghany Sara Hosny , Ahmed Omar Thoria , Abdelaziz Alyaa Ahdy
Published: February 2025

Background. In children admitted to the pediatric intensive care unit (PICU), early detection of risk factors and alarming indicators improves the prognosis and may even save lives. Several prognostic markers and scores have been studied in children who are seriously ill. Recently, surface triggering receptor expressed on myeloid cells-1 (sTREM1) has been studied in many infectious and non-infectious settings; however, there is little information on critically ill children. Our aim is to evaluate the sTREM1 level in critically ill children and assess its prognostic role.
Method. A prospective observational study was conducted in a tertiary care hospital. 70 critically ill children and 50 healthy controls were enrolled in the study. Demographic, clinical, and laboratory data were obtained. sTREM1 level was assessed on admission to the PICU. Patients with conditions affecting immunity were excluded. The primary outcome was to assess the level of sTREM1 in both patients and controls. Secondary outcomes were mortality, morbidities as sepsis, need for mechanical ventilation, and PICU stay.
Results. The level of sTREM1 was significantly higher in patients than in controls (850 pg/mL, interquartile range [IQR] 510.0- 1375.0 vs. 67.5 pg/mL, IQR 40.0- 85.0; p
Blended problem based learning in postgraduate education: The Eastern Allergy Conference and the PBL Institute experience
Authors: Conway Alexandra E. , Kartha Navya , Shaker Marcus S. , Davis Ray S. , Settipane Russell A. , Bukstein Don A.
Published: February 2025

Problem-based learning (PBL) is an interactive learning model well accepted in undergraduate medical education. Utilization of PBL in most postgraduate continuing medical education (CME) programs has been limited. The traditional didactic lecture (TDL) model alone in CME programs, although
much more commonly used, may fail to assess self-efficacy, educational needs, and appropriate use of shared decision-making (SDM). These aspects of practice are essential, and assessment of these skills is necessary to ensure effective change in physician behavior to improve patient outcomes.
PBL case discussions during CME breakout groups foster a participant-centered interactive environment that strengthens critical thinking, team collaboration, and clinical reasoning. Through engagement with clinically relevant cases, PBL allows for tailored educational interventions. Integrating
or blending PBL with TDL engages the learners in a real-world case discussion first, followed by succinct post-PBL lectures, which are uniquely “in context” to the actual case discussion. The post-PBL lectures are designed to address knowledge gaps that may have been uncovered
during the PBL case discussions and reinforce practice guidelines to correct identified misinformation by learners. The PBL approach not only improves knowledge retention but also leads to better adherence to clinical guidelines by producing significant changes in physician behavior, leading
to higher-value patient care. Furthermore, PBL promotes effective and appropriate SDM. Still, there are challenges to PBL implementation in postgraduate CME, including logistical constraints and facilitator training requirements. Thus far, integration of PBL is variable across fields of medicine.
Further research is needed to optimize PBL application in postgraduate training. This review advocates for a shift from passive learning systems by TDLs alone to interactive educational models, e.g., blended PBL, which synergizes the two adult learning theories.
Autogestion
Authors: Stone Livia
Published: February 2025

This article describes the history of the origins of the important principle of autogestion (autogestion in French, autogestión in Spanish, generally self-management in English) and straightening its often-confused origin story. Based in an examination of mid-twentieth century French scholarship, journals, and political documents, this article argues that the term did not arise out of Yugoslavia of the 1950s, or the French student movement of 1968, but from a collective of Algerian revolutionaries at the point of Algeria’s independence 1962-1965. Furthermore, the article corrects some English translations of the word in historical documents that have further confused its history and had an impact on how the principle was adopted in the English-speaking world. The origin of the term is important because within its grammar is the most important shift in leftist social movements of the twentieth century: the shift from “worker” or “peasant” as the revolutionary subject to a variety of collective selves in the “new” identity-based social movements of the 1960s and beyond. To recuperate autogestion’s origins as North African is to recuperate a portion of the importance of Global South activists and political thinkers to the 1968 student movements that have been so defining of our contemporary political landscape.
Godfrey Goodman and George Hakewill on the decay of the world
Authors: Drozdek Adam
Published: February 2025

The end of the sixteenth and the beginning of the seventeenth century was marked by theological discussions concerning the decay of the world. Godfrey Goodman in The fall of man presented an extensive argument in favor if inherent corruptibility of the world that gradually heads to its destruction and George Hakewill countered with a book-long rebuttal of this view. The views of these two clergymen are presented in this article both of whom trying to enhance by common opinion that the world was created to express the glory of God.
Między patriarchatem a autokefalią
Authors: Moskałyk Jarosław
Published: February 2025

Ukraiński Kościół Prawosławny Patriarchatu Moskiewskiego przeżywa obecnie największy kryzys od początku swojej ponad 30-letniej działalności na Ukrainie. Jest to niewątpliwie wynik rozpętanej przez Federację Rosyjską wojny w lutym 2022 roku, ale także głębokich więzi łączących tę organizację religijną z ośrodkiem władzy duchowej w Moskwie. Oba te czynniki powodują jego ogromną destabilizację wewnętrzną i obniżenie autorytetu moralnego w społeczeństwie. Dodatkowo na utratę wiarygodności przez wskazany podmiot istotny wpływ ma podział w strukturach hierarchicznej władzy oraz stosowanie półśrodków w zakresie własnej autonomii. Brak jasnego i spójnego stanowiska w sprawie postawy zwierzchnika Patriarchatu Moskiewskiego Cyryla i tej Cerkwi wobec rosyjskiej agresji na Ukrainę odbija się wciąż negatywnym echem. Cała ta sytuacja ma niezwykle negatywny wpływ na bieżącą działalność podporządkowanego Moskwie ukraińskiego prawosławia i prowadzi do jego nieuchronnego podziału. Problem relacyjności wewnątrz tejże wspólnoty oraz perspektywa autonomii w ramach tradycji kijowskiej będzie przedmiotem poniższej analizy i konkluzji.
Katolicka teologia moralna wobec wyzwań sekularyzacji i sekularyzmu. Kilka uwag w perspektywie myśli Joachima Piegsy MSF (1930–2015)
Authors: Podzielny Janusz
Published: February 2025

Sekularyzacja, która często przeradza się w sekularyzm, oddalając się tym samym od pozytywnej koncepcji świeckości, wystawia na trudną próbę życie współczesnych chrześcijan, szczególnie na Zachodzie. Konkretne postulaty, które mają na celu przeciwstawienie się tym negatywnym trendom, proponuje katolicka teologia moralna. Tu temat sekularyzacji i sekularyzmu wybrzmiewa głównie jako zagrożenie dla teologalnej cnoty wiary oraz cnoty religijności. W niniejszym artykule, po doprecyzowaniu pojęć sekularyzacji i sekularyzmu oraz krótkim omówieniu aktualnego zasięgu tych zjawisk (zwłaszcza w Polsce), zostaną zaprezentowane konkretne postulaty teologicznomoralne autorstwa Joachima Piegsy MSF (1930-2025). Mogą być one pomocne dziś w przezwyciężeniu lub ograniczeniu procesów sekularyzacyjnych. Chodzi przede wszystkim o: powrót do Dekalogu, prawdy oraz świadectwa chrześcijańskiego życia.
Jerzy Klinger i Jerzy Nowosielski: myśli o liturgii
Authors: Hajduczenia Łukasz
Published: February 2025

Artykuł jest rozważaniem na temat wybranych myśli ks. Jerzego Klingera dotyczących liturgii prawosławnej. Myśli te są jednocześnie obecne w wielu wypowiedziach Jerzego Nowosielskiego. Wspólne intuicje obu przyjaciół stanowią podstawę do refleksji teologicznej, prowadzącej do wniosków krystalizujących takie pojęcia jak: teologia prawosławna, liturgia, praktyka liturgiczna czy piękno. Wzajemne uzupełnienie się słynnych malarza i teologa, w rezultacie jest decydujące o jakości ich twórczości. Jerzy Nowosielski dzięki temu konstruuje niezwykle interesujący dyskurs dotyczący swojej sztuki. Natomiast ks. Jerzy Klinger tworzy teologię odważną, w której staje się artystą dalekim od teoretyzowania.
Wieczerza Pańska w perspektywie dialogu ekumenicznego
Authors: Mateja Erwin
Published: February 2025

Liturgia, a zwłaszcza Ofiara Eucharystyczna była dla pierwszych chrześcijan centrum ich życia religijnego. Kolejne wieki były areną licznych sporów i kontrowersji, które dotyczyły rozumienia Eucharystii. Także nasze czasy pokazują, że niezależnie od tego, czy nazywamy ją Mszą św., liturgią eucharystyczną czy Wieczerzą Pańską, nie buduje ona ciągle tej wspólnoty, którą chrześcijanie, niezależnie od tego, do którego Kościoła należą, tworzyć powinni. W niniejszym przedłożeniu podjęta została próba pokazania, jak wiele już osiągnięto w dyskusjach ekumenicznych na interesujący nas temat, ale też, co jeszcze musi być przemyślane, by sprawowana we wspólnotach chrześcijańskich liturgia Eucharystii gromadziła przy jednym stole wszystkich wyznawców Chrystusa. Dlatego najpierw sięgamy do źródeł biblijnych, by tam szukać istoty omawianego sakramentu, następnie zostaje przedstawiona doktryna katolicka, prawosławna i protestancka. W osobnym punkcie przypomniane jest miejsce Eucharystii w dialogu ekumenicznym, by w zakończeniu skoncentrować się problemach, które są ciągle otwarte, a które trzeba rozwiązać, aby celebrujący Eucharystię chrześcijanie pamiętali, że stawia im ona zadanie budowania jedności, której idea wybrzmiała w modlitwie arcykapłańskiej Chrystusa, aby wszyscy stanowili jedno.
Exploring Variation and Change in the Distant Past
Authors: Hernáiz Rodrigo
Published: February 2025

This article explores the potential of analysing language variation and change in written records dating back to the earliest stages of the time period conventionally termed ‘historical’. In particular, it considers the suitability of Old Babylonian data, a Semitic language from the early II millennium BCE, as object of historical sociolinguistic investigation. A case study focuses on the representation of sibilants in texts from a relatively extensive corpus of letters. Its analysis is framed within the scope of testing the temporal limits of variationist approaches to language change and its uniformitarian premises. The study offers detailed linguistic insights from textual documentation going back nearly four thousand years, a period in which most languages spoken at that time remain undocumented (i.e., are ‘prehistorical’), and can only be inferred or reconstructed.
Savunma Harcamaları ve Kurumsal Kalitenin Gelir Eşitsizliğine Etkisi: Türkiye’den Yeni Kanıtlar
Authors: Durgun Burhan
Published: February 2025

Eşitsizliğe etki eden faktörlerden biri olduğu ileri sürülen savunma harcamaları, ilgili literatürde kısıtlı bir alan kaplamaktadır. Türkiye’nin bulunduğu coğrafyadan kaynaklı olarak karşı karşıya kaldığı güvenlik risklerini azaltmak için savunma harcaması yapmak zorunda olması ve ülke içinde artan gelir eşitsizliği nedeniyle savunma harcamaları ve eşitsizlik bağının anlaşılması önem arz etmektedir. Bu çalışmada, 1988-2023 döneminde Türkiye’de savunma harcamaları, sefalet endeksi, büyüme ve kurumsal kalitenin gelir eşitsizliğine etkisi araştırılmıştır. RALS-ADL eşbütünleşme yönteminin kullanıldığı çalışmada uzun dönem ilişkisi doğrulanmıştır. Uzun dönem esneklikleri, büyüme ile eşitsizlik arasında düz U şekilli bir ilişkinin olduğunu göstermiştir. Ayrıca sefalet endeksi ve savunma harcamalarının eşitsizliği arttırdığı ve kurumsal kalitenin etkisinin anlamsız olduğu tespit edilmiştir. Düz U şekilli ilişkinin varlığı büyümenin uzun vadede eşitsizlik yaratacağını ifade etmektedir. Buna ek olarak eşitsizliğin artan savunma harcamaları ve yüksek enflasyonist süreçle daha da derinleşebileceği öngörülmektedir. Kurumsal kalite düzeyinin eşitleyici etkiden uzak olması da yine Türkiye açısından olumsuz bir tablo ortaya koymaktadır. Düşük gelirli kesime yönelik sosyal koruma harcamalarının arttırılmasının yanında, savunma harcamalarında etkinliğin sağlanması ve makroekonomik politikaların piyasalar üzerinde enflasyonist baskı yaratmayacak şekilde tasarlanması gerekmektedir.
Determination of an Unsteady Temperature Field in a Multilayer (Three-Layer) Cylindrical Module Samples of Siege
Authors: Hagba G. S.
Published: February 2025

The temperature field of a three-layer thermoelement based on SiGe was studied in a non-stationary mode. Based on the analysis of the process, a mathematical model of unsteady heat transfer is proposed and justified. Analytical dependencies for the operation of a non-stationary temperature field are obtained. The temperature distribution in cylindrical layers has been studied. For each layer, thermal conductivity coefficients, Fourier criteria, Biot criteria, as well as the thermal emf coefficient are calculated.
Causality Effects of Capital Accumulation and Employment on Turkey’s Economic Growth: Findings from the Toda-Yamamoto Approach
Authors: Turna Yaşar
Published: February 2025

A time-dependent change in the amount of goods and services produced in an economy refers to economic growth. Economic growth is considered an important factor in increasing the welfare of a society and in determining the level of development of countries. Therefore, all countries in the world endeavour to increase their economic growth performance. By increasing the economic growth performance of countries, opportunities to compete with other economies increase because of the increase in production activities in the economy. Therefore, economic growth is considered to be one of the most important issues in the economy in terms of its causes and consequences. This framework aims to test the effects of capital accumulation, employment level, and technological progress factors on economic growth in Turkey between 1990-2021. For this purpose, the relationships between the variables were analysed using the Toda-Yamamoto causality test. The analyses revealed that capital accumulation, employment level, and technological progress have a statistically significant relationship with economic growth. This result is consistent with the hypotheses regarding the determinant role of capital, labour, and technology factors in economic growth, which are put forward in Solow's neoclassical growth model and endogenous growth theories.
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Treatment of Anemia in Chronic Kidney Disease: Guidelines for South Asia
Authors:   South Asia HIF-PHI for Anemia in CKD Guideline Development Group, Abraham Abi , Almeida Alan , Bhalla Anil Kumar , Chaudury Arpita Ray , Dutta Arup Ratan , Gupta Ashwani , Shah Bharat , Roy Biswajeet , Subbarao Budithi , Herath Chula , Amrutha Cynthia , Shah Dibya Singh , Pahari Dilip Kumar , Khullar Dinesh , Bajpai Divya , Simaladinne Guruvulu Venkata , Kothari Jatin , Tyagi Jyoti , Sharma Inika , Shah Kamal , Malik Manish , Sahay Manisha , Sharma Manjuri , Gumber Manoj , Sreelatha Melemadathil , Tiwaskar Mangesh , Kaur Manveen , Alam Muhammed Rafiqul , Gopalakrishnan Natarajan , Prasad Narayan , Kamath Nivedita , Meena Priti , Varma Prem Prakash , Das Pratik , Ramachandran Raja , Sharma Raj Kumar , George Reena , Jain Salil , Ingale Samiksha , Moola Sandeep , Bhattacharya Sandip Kumar , D’Cruz Sanjay , Gulati Sanjeev , Saxena Sanjiv , Sundar Sankaran , Acharya Shivnarayan , Bansal Shyam Bihari , Vishwanath Siddini , Gang Sishir , Raju Sree Bhushan , Parameswaran Sreejith , Bhaumik Soumyadeep , Madhu Sri Venkata , Alexander Suceena , Jeloka Tarun , Saha Tarun Kumar , Das Tonmoy , Anandh Urmila , Khanna Umesh , Bhatia Virat , Saxena Vishal , Kher Vijay , Raghavan Vasundhara , Jha Vivekanand ,   *Steering Committee†,   Methodology Committee (non-voting)#,   Guideline Development Panel$
Published: February 2025

This guideline addresses the use of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in patients >18 years with chronic kidney disease (CKD) and anemia in South Asia (Bangladesh, Bhutan, Nepal, India, Pakistan, Sri Lanka). It also summarizes recommendations for anemia treatment for individual HIF-PHI molecules under two categories: dialysis-dependent and non-dialysis-dependent CKD patients. The recommendations do not apply to pediatric (≤12 years) and adolescent (12 to 18) patients or those with primary anemia or anemia secondary to other causes such as blood loss, cancer (any type), polycystic kidney disease and infectious diseases.
Application of cyanoacrylate glue in corneal impending perforation (descemetocele) under slit lamp biomicroscope
Authors: Ramatchandirane Balamurugan , Patil Goudappagoud R. , Devalla Mansi Dinesh
Published: February 2025

A male in his sixties had been treated outside initially as right eye suspected viral stromal keratitis with oral acyclovir and topical prednisolone 1% and later as suspected microsporidial stromal keratitis with oral albendazole, topical voriconazole 1% and topical prednisolone 1%. In our management, we have ruled out microsporidia by corneal scraping, restarted antiviral treatment, and stopped topical prednisolone in view of the epithelial defect. The patient slowly improved with the complete disappearance of the infiltrates, but there was a persistent epithelial defect that turned into a descemetocele. Hence, we have performed cyanoacrylate glue application on the descemetocele under a slit lamp biomicroscope in outpatient department (OPD) settings. In this case report, we have demonstrated and educated the important steps and precautions in the corneal tissue adhesive glue application under a slit lamp biomicroscope in OPD settings.
Miniaturization of MALDI Mass Spectrometers with the Technological Breakthrough of the Digital Ion Trap: Peptide and Protein Analysis in MS1, MS2, and MS3
Authors: Baumeister Andreas , Sellami Lyna , Nakaya Shuichi
Published: February 2025

A digital ion trap (DIT) mass spectrometer was developed to extend the mass range in comparison to conventional ion traps. This was achieved by changing the RF voltage from a sinusoidal to a rectangular waveform. In addition to the extended mass range, the size of the instrument was miniaturized. To show the benefits of this development, MALDI applications in MS1, MS2, and MS3 are presented: On one hand, it is possible to analyze intact proteins, on the other hand the instrument enables insights into the structure of antibodies and glycoproteins after enzymatic digestion and collision-induced dissociation (CID).
On Paper Diagnostics: A Brief History and Future Perspectives
Authors: Richards Daniel , DeMello Andrew , Khosla Nathan
Published: February 2025

For centuries, diagnostic technologies have played a key role in medicine. Effective diagnostics can help clinicians identify the presence and extent of disease in their patients, as well as their general health. Precipitated by advances in biochemistry, chemistry, and engineering, the 20th and 21st centuries have witnessed rapid advancement in diagnostic technologies. However, these improvements have brought increased complexity and a corresponding move towards more centralized and specialized laboratories. This has led to significant healthcare disparities between high- and low/middle-income regions. However, with the introduction of paper-based diagnostics this paradigm has begun to shift, with new assay formats designed for point-of-care (PoC) or at-home use. By leveraging innovations from multiple fields, these paper-based tests can translate complex assay procedures into easy-to-use, single-step tests for the end user. In this review, we summarize the interdisciplinary beginnings of paper-based diagnostics, detailing their development through market introduction and commercial successes, and discuss the current state-of-the-art. Finally, we highlight areas for improvement and propose pathways that could enable increasingly complex chemistries to be performed on simple paper-based devices.
РАСПРОСТРАНЕНИЕ И ВСТРЕЧАЕМОСТЬ ВРЕДНЫХ КЛОПОВ НА ЗЕРНОВЫХ КУЛЬТУРАХ В УЗБЕКИСТАНЕ
Authors: Бекчанов З.Б.
Published: February 2025

В статье рассматриваются проблемы, связанные с воздействием вредных клопов на зерновые культуры в условиях изменения климата. Исследования сосредоточены на основных вредителях, таких как Eurygaster integriceps и другие представители вредных клопов, их биоэкологических особенностях, влиянии на урожайность и качестве зерна. Представлены данные о распространении вредителей в регионах Узбекистана. Исследования охватывают 2008-2022 годы и включают анализ популяции вредителей, их ареал, а также уровень встречаемости вредных клопов на зерновых культурах.
РАЗРАБОТКА ИНФОРМАЦИОННОЙ СИСТЕМЫ ОЦЕНКИ ОРГАНИЗАЦИОННОЙ ЗРЕЛОСТИ БИЗНЕС-ПРОЦЕССОВ УПРАВЛЕНИЯ КОНТИНГЕНТОМ СТУДЕНТОВ
Authors: Вальков К.В. , Демидюк В.Д. , Доррер М.Г. , Лукьянов С.В.
Published: February 2025

Статья рассматривает актуальную проблему повышения эффективности управления контингентом студентов в высших учебных заведениях. В работе предлагается разработать специализированную информационную систему, предназначенную для оценки уровня зрелости бизнес-процессов, связанных с переводом, отчислением студентов. Авторы рассматривают теоретические основы понятия организационной зрелости, анализируют существующие методики оценки и предлагают собственную модель, адаптированную к специфике образовательной среды. Особое внимание уделяется функциональным возможностям разрабатываемой системы, таким как сбор и анализ данных, расчет показателей зрелости, визуализация результатов и формирование отчетов.
НОВЫЕ МАТЕРИАЛЫ С ГОРОДИЩ ФИНАЛА РАННЕГО ЖЕЛЕЗНОГО ВЕКА: К ВОПРОСУ О «ВОЙНЕ I в. н. э.»
Authors: Сыроватко А.С.
Published: February 2025

В статье публикуется комплекс предметов, полученный в ходе обследования трех городищ дьяковской культуры. Все городища обнаружены в бассейне правого берега р. Оки, недалеко от города Зарайска Московской области (рис. 1). Предметы с городища Аргуново (рис. 2; 3) относятся к I–II вв. н. э. Им близки по времени предметы с городищ Власьево (рис. 4: 12–14) и Апонитищи 1 (рис. 3: 1–11). Похожий набор ювелирных украшений и вооружения найден на городищах в Туль ской области: Страхово 2, Слобода, Малая Стрекаловка. Происхождение комплексов с городищ Тульской области связывают с древностями андреевско-писеральского типа и пьяноборской культуры, которые попадают в Тульскую область в результате событий, получивших название «война I в.» (Воронцов, Столяров, 2019). В статье отмечается, что, несмотря на близость предметов, обнаруженных на городищах возле Зарайска, артефактам, обнаруженным на городищах возле Тулы, керамика этих двух групп памятников отличается кардинально (рис. 5). Это обстоятельство ставит под сомнение идею «войны I в.» как причину распространения единого типа украшений и вооружения на широкой территории.

The paper publishes a set of items obtained during investigation of three Dyakovo hillforts. All the sites have been discovered in the basin of the Oka right bank not far from the town of Zaraysk in the Moscow region (Fig. 1). Items from the Argunovo fortified settlement (Fig. 2; 3) date from the 1st–2nd centuries AD. Items from the Vlasyevo hillfort (Fig. 4: 12–14) and the Aponitishchihillfort (Fig. 3: 1–11) are al most contemporary with them. A similar set of jewelry and weapons has been found at Strakhovo-2, Sloboda, and Malaya Strekalovka, which are hillforts of the Tula re gion. The origin of the assemblages from the Tula region fortified settlements is linked to the antiquities of the Andreevskoe-Piseralsk type and the Pyany Bor culture, the items from these assemblages got into the Tula region during the events known as «the 1st century war» (Vorontsov, Stolyarov, 2019). The article notes that, despite some similarity between the artifacts found at the sites near Zaraysk and those discovered at the fortified settlements near Tula, the ceramics from these two groups of sites differ drastically (Fig. 5). This circumstance calls into question the idea that the dissemination of one-type jewelry and weapons across this vast area was caused by «the 1st century war».
ЛИТЕЙНЫЕ ФОРМЫ ДЛЯ ИЗГОТОВЛЕНИЯ УКРАШЕНИЙ ИЗ СВИНЦОВО-ОЛОВЯННЫХ СПЛАВОВ С ПОЗДНЕДЬЯКОВСКИХ ПАМЯТНИКОВ ПОДМОСКОВЬЯ
Authors: Тавлинцева Е.Ю.
Published: February 2025

В третьей четверти I тыс. н. э. литейные формы для отливки свинцово- оловянных украшений были распространены на обширной территории, которая вклю чала в том числе и бассейн Москвы-реки. В отличие от других регионов на москворецких позднедьяковских городищах чаще встречаются глиняные формы: всего 27 на ходок на шести городищах, в то время как каменных – только 15 экземпляров с трех памятников. Как каменные, так и глиняные формочки связаны с позднедьяковским временем и могут датироваться достаточно широко – в рамках всей третьей четверти I тыс. н. э., что не противоречит датировке находок за пределами региона. Ряд косвенных признаков позволяет предположить, что глиняные формы для изготовления мел ких свинцово-оловянных украшений могли использоваться в лесной зоне Восточной Европы до появления там каменных формочек. Негативы украшений, встреченные на глиняных формах, стилистически связаны в основном с местной ювелирной традицией либо относятся к общераспространенным типам. Вопрос об их точной датировке по-прежнему остается открытым. Появление каменных форм в бассейне Москвы-реки относится к более позднему времени и связано с приходом туда нового населения, по-видимому, из Верхнего Поднепровья. Городище Хлепень может рассматриваться как своего рода промежуточный пункт на этом пути. На этом этапе каменные и глиняные формочки сосуществуют, в том числе в рамках одной мастерской.

In the third quarter of the first millennium AD casting molds for making lead tin jewelry were widespread across a vast area that included, among other places, the Moskva-river basin. Unlike other regions, clay molds are more common at the Moscow region Late Dyakovo fortified settlements (27 finds from six fortified settlements in total), whereas the number of stone molds found at three sites is only 15. Both stone and clay molds are linked to the Late Dyakovo period and can be dated to a rather wide period, covering the en tire third quarter of the first millennium AD, this time span agrees with the dates of the finds outside the region. A number of indirect attributes suggest that the clay molds for making tiny lead-tin jewelry were, probably, used in the forest belt of eastern Europe before appearance of stone molds. The traces of the jewelry pattern in reverse on the interior side of the clay molds are stylistically linked, mainly, to the local jewelry tradition or are thought to be of common types. The issue of their accurate dating is still pending. The appearance of stone molds in the Moskva-river basin is dated to a later period and is linked to the arrival of newcomers, apparently, from the Upper Dnieper region. The Khlepenfortified settlement may be considered to be a way station on this route. During this stage the stone and clay molds were used in parallel, in some cases, in the same workshop.
«КЕРАМИЧЕСКАЯ СТРАТИГРАФИЯ» СТАРОЙ ЛАДОГИ
Authors: Сениченкова Т.Б.
Published: February 2025

Существующая в культурной стратиграфии Северо-Запада хронологическая лакуна, охватывающая середину – третью четверть I тыс. н. э., постепенно начинает заполняться т. н. «предсопочными» памятниками. В статье описываются отдельные фрагменты керамики, найденные на территории Старой Ладоги и относящиеся к разным хронологическим периодам («стратам»). На основе мини-серий сосудов из ладожского керамического комплекса сделана попытка выявить отдельные составляющие формирующейся древнерусской культуры.

Presently, the existing chronological gap covering the middle – third quarter of the 1st century has started to be filled up with the so called presopka type sites. The pa per seeks to identify specific components of the emerging Medieval Russia culture based on the analysis of some distinctive features of the Ladoga ceramic assemblage.
САЛТОВСКИЙ СЛЕД В МАТЕРИАЛАХ СТАРОЙ ЛАДОГИ
Authors: Григорьева Н.В. , Павлова М.С.
Published: February 2025

В статье собраны сведения о находках так называемого салтовского круга древностей с территории Ладожского поселения и его округи, как известные по печатным материалам, так и не публиковавшиеся ранее. Под салтовской авторы понимают культурно-историческую общность кочевого и полуоседлого населения Хазарского каганата второй пол. I тыс., имевшую широкий ареал расселения и узнаваемую материальную культуру. Вещи попадали в Ладогу по Волжскому торговому пути. На данный момент учтено около 40 изделий, которые происходят с территории Земляного городища, каменной крепости и из сопок. Впервые публикуется ряд находок из каменной крепости и раскопов в южной части Земляного городища. Следует отметить выявление среди керамической коллекции из раскопок В. И. Равдоникаса нескольких фрагментов специфической тарной посуды – высокогорлые сосуды с плоскими ручками (ВКПР). Особый интерес представляют изделия местной полифункциональной мастерской, в которой в середине IX в. производились бляшки южно-степных типов, но из доступных на месте легкоплавких сплавов и при помощи знакомых мастеру технологических приемов.

The paper has collected information on the finds of the so called Saltovo ‘family of cultures’ from the Ladoga settlement and its vicinities known from earlier publications as well as those not released yet. The authors take the Saltovo culture to a cultural and historical community of nomadic and semi-sedentary populations of the Khazar Khaganate from the second half of the first millennium who inhabi ted a vast area and had an identifiable material culture. The items reached Ladoga via the Volga trade route. Presently, around 40 items originating in the Zemlyanoe hillfort, the stone fortress and hills have been accounted for. This paper is the first to publish a number of finds from the stone fortress and excavation trenches in the southern part of the Zemlyanoe hillfort. It should be noted that the ceramic assemblage from the ex cavations led by V. I. Ravdonikas has contained several fragments of specific trans port ware (high-necked jars with ribbon handles). Of special interest are products made at a local polyfunctional workshop. In the se cond half of the 9th century this workshop produced plates of southern steppe types using locally available low-melting alloys and employing techniques familiar to the artisans.
ТАФТА ЛАНСЕ ИЗ КУРГАНА № 6 БЕЛОРЕЧЕНСКОГО МОГИЛЬНИКА
Authors: Теплякова А.Н.
Published: February 2025

Статья посвящена проблеме реконструкции орнамента, технологических аспектов изготовления, атрибуции и датировке фрагмента ткани из кургана № 6 Белореченского могильника (раскопки Н. И. Веселовского, 1896 г.). Основа ткани полотняного переплетения. Ее узор образуется при помощи введения дополнительного узорного утка (золотных нитей) и состоит из фигуры дракона и облачной ленты. Шелк следует относить к ткаческим мастерским Китая или Центральной Азии XIII–XIV вв., это самая ранняя ткань среди узорных тканей Белореченского могильника в коллекции Государственного Эрмитажа и единственная, которую следует связывать с дальневосточным импортом.

The article is devoted to the problem of the ornament reconstruction, techno logical aspects of production, attribution and dating of the textile fragment from kurgan No. 6 of the Belorechenskiy burial ground (excavations by Nikolay Veselovsky, 1896). Textile has a plain weave. Its pattern is formed by introducing an additional patterned weft (metal thread) and includes an image of a dragon and a cloud ribbon. Silk should be at tributed to the weaving centers of China or Central Asia of the 13th–14th centuries. Thus it is the earliest fabric among the figured textiles of the Belorechenskiy cemetery in the col lection of the State Hermitage museum and the only one that should be associated with Far Eastern imports.
Stepwise Spin-State Switching with Symmetry Breaking and ON/OFF Photo-switching in Iron(II) Complex
Authors: Mehta Sakshi , Kamilya Sujit , Ghosh Sounak , Sarkar Debopam , Li Yanling , Lescouëzec Rodrigue , Rouzières Mathieu , Pechoušek Jiří , Mondal Pradip Kumar , Abbas Irshad Kariyattuparamb , Joseph Boby , Ghosh Subrata , Mondal Abhishake
Published: February 2025

In recent world advancement and the quest for smart multi-functional material, stimuli-responsive molecular bistable systems offer unique opportunities to explore their applicability in molecular switches, data storage, and sensing technologies. Multi-stimuli responsive stepwise Spin Crossover (SCO) systems stand tall in this area. While the effects of external stimuli, particularly thermal variations and photoirradiation on the magneto-structural properties of SCO systems have been extensively studied, the area of pressure-modulated stepwise spin crossover and its associated magneto-structural changes remains lesser explored. Herein, we report a mononuclear iron(II) complex containing tetradentate macrocyclic ligand with -diimine-based bidentate coligand, [Fe(L)(bik*)](BPh4)2 (1) (L = N,N'-di-iso-propyl-2,11-diaza[3,3](2,6)pyridinophane and bik* = bis(1-ethyl-1H-imidazol-2-yl)ketone)) undergoing a reversible stepwise thermo-induced spin-state switching with the presence of three spin-states HS, LS, and an ordered HS-LS with the exciting re-entrant symmetry breaking during the spin-state switching process. The influence of external pressure on the structure and magnetic response is thoroughly studied, where the pressure-induced modification in the intermolecular interactions leads to enhanced cooperativity and a hysteretic stepwise spin state switching. The versatility of the systems is further explored where 1 displays a reversible ON/OFF photo-switching between a photo-induced paramagnetic metastable HS and diamagnetic LS states under light irradiations at low temperatures along with light-induced excited spin state trapping (LIESST).
Development of Parallel On-the-Fly Crystal Algorithm for Reaction Discovery in Large and Complex Molecular Systems
Authors: Pandey Ankit , Costa Gustavo J. , Mushfiq Alam , Poirier Bill , Liang Ruibin
Published: February 2025

The parallel on-the-fly Crystal algorithm is a new, efficient global search algorithm that has found utility in exploring the single-state potential energy surfaces and conical intersection seam spaces of a wide range of molecules in the gas phase. Despite its major developments, its application to complex molecular systems, especially in the condensed phase, remains challenging due to the high dimensionality of the configurational space. In this work, we address this challenge and extend its applicability to the reaction discovery of large, complex molecular photoswitches in the condensed phase. This is achieved by improved search algorithms that facilitate the exploration of a comparatively large Crystal configurational subspace while relaxing the other degrees of freedom. The new Crystal algorithm is applied to bilirubin and a next-generation class of molecular photoswitches in the vacuum and the aqueous solution environment in a quantum mechanics/molecular mechanics (QM/MM) setting. We designed an automatic and systematic workflow to discover previously unreported minima and low-energy reaction pathways and analyze them with a focus on the low-energy spectrum. Our findings reveal the algorithm's effectiveness in quickly exploring the configuration space, uncovering new product minima that are kinetically accessible, which provides new insights into the intricate chemical reactivities of these molecules. The results underscore the promising potential of parallelized global exploration methods in reaction discovery in biomolecular systems.
Defining stereoisomeric configuration spaces and subspaces for arbitrary coordination centres ABn
Authors: Canfield Peter , Crossley Maxwell , Spreer Jonathan , Tillmann Stephan
Published: February 2025

The range of geometric configurations possible for an arbitrary coordination centre ABn, is a key aspect of stereoisomerism and molecular geometry in general. Despite this, much focus within Chemistry concerning ABn geometries has not taken a rigorous and holistic approach. Using a precise definition for configurations based upon the interior angles at the A-atom, we present a general method for describing ABn configuration spaces or their subspaces. The method uses angle-changing molecular vibrational normal modes as a basis to locally describe the spaces. A consequence of using a physically inspired method is that the configuration spaces map onto physical mechanisms (“polytopal rearrangements”). The space of local configurations and their subspaces are amenable to compactifications modelled on chemical processes. A contiguous symmetry based discretisation method that allows for the configuration spaces to be encoded as graphs is presented. Numerous worked examples are given.