bluuebunny/crossref_metadata_2025 huggingface dataset:
The Qur'anic Perspective Of Surah Al-Humazah Manifests The Values Of Islamic Education
Authors: Upiyani  , Rumbang Sirojudin  , Enung Nugraha  , Wasehudin  , Susari
Published: August 2024

This study was inspired by a crisis of Islamic values in education that has been getting worse because of a lack of material things, social and cultural issues, and the loss of Islamic values and principles. There are real beliefs and great examples all around us. As a result, the Qur'an, which is the source of all knowledge, provides resources and useful examples for the development of value-based education. Regardless of the structure of the verse, every verse in the Qur'an has an instructive value that can be explored and expanded. Surah al-Humazah is one of the verses in the Quran that highlights the importance of education. This verse is a threat to anyone who harasses others, promotes untruth and unprofitable information, swears, or gathers money. The study of the educational ideals in the Al-Qur'an al-Humazah letters is the subject of this research, which uses qualitative methodology and focuses on the library research style (library research). To contextualize the values of education in al-Humazah's letter, we need to consider the following: The importance of moral education to God as a servant who is always satisfied with the command of his Creator. It is closely related to the significance of moral instruction to each other (humanity), which ensures that life together is always peaceful, safe, enjoyable, and life. As well as having a sense of sympathy and empathy that is a form of social education values towards each other.
PENGARUH KECERDASAN SPIRITUAL, KONSEP DIRI, DAN DUKUNGAN SOSIAL TERHADAP KECEMASAN MENGHADAPI MASA PENSIUN PEGAWAI UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG
Authors: Dewi Emi Puspita
Published: August 2024

Abstract : This research aims to find (1) influence of Spiritual Intelligence, Self Concept, and Social Support simultaneously to the Employee Anxious in Retirement at Raden Fatah State Islamic University of Palembang, dan (2) Influence of Spiritual Intelligence, Self Concept, and Social Support partially to the Employee Anxious in Retirement at Raden Fatah State Islamic University of Palembang. Sample in this research as much 107 persons. Method used in this research is multiple regression model. There are four variables. Those are independent variables which Spiritual Intelligence, Self Concept and Social Support, and also dependent variables is Anxious in Retirement. The analytical tool used is multiple linear regression. According to the research result, find: (1) There is a negative and significant effect Spiritual Intelligence, Self Concept, and Social Support simultaneously to the Employee Anxious in Retirement at Raden Fatah State Islamic University of Palembang, and (2) There is a negative and significant effect Spiritual Intelligence Self Concept, and Social Support partially to the Employee Anxious in Retirement at Raden Fatah State Islamic University of Palembang. Keyword : spiritual intelligence, self concept, social support and anxious in retirement.
MANAJEMEN PENYELENGGARAAN IBADAH HAJI
Authors: M. Nur Dalinur
Published: August 2024

Professional and accountable management is a probem solving of complex problems around the implementation of Hajj. Hajj management is a process of organizing or managing Hajj activities by using management functions that include planning, organizing, actuating, controlling, and evaluating, so that the pilgrimage is carried out effectively and efficiently. Hajj is a process, method, and act of organizing or carrying out a series of Hajj activities that include guidance, service, protection, and implementation of the Hajj. Hajj guidance is a series of activities that include information, counseling, and guidance, on the pilgrimage. Services include all activities to provide services to all prospective pilgrims and pilgrims, from registration to returning to the country, including transportation, accommodation and health services. Protection is the efforts made by the government to ensure the safety and comfort of pilgrims which includes maintaining the safety of pilgrims while in Saudi Arabia and safeguarding the items of pilgrims while in boarding.
Key Words: Management, Hajj
WARISAN MONUMENTAL PENINGGALAN KESULTANAN PALEMBANG DARUSSALAM YANG TERAKULTURASI
Authors: Darmawan Candra
Published: August 2024

Historical records, Palembang was victorious during the Srivijaya kingdom, and even became a center of international trade, this made the immigrants from various countries great concern to come to the Sriwijaya kingdom. those who are motivated to spread religion (da'wah, missionaries, zending), there are also those who wish to colonize/control completely the natural wealth owned by Sriwijaya. The heritage of Sriwijaya, namely the monumental buildings of the Palembang Darussalam Sultanate, can still be found in Palembang, such as the Palembang Grand Mosque, Merogan Mosque, Suro Mosque, Kuto Besak Fort, the tombs of the Sultan of Palembang, including the Gede Ing Suro Tomb, Angsoko Temple Tomb, Sabo Tomb. Kingking, Walang Temple Tomb, Tengkurep Crater Tomb, and Limas House.
Keywords: Heritage, Sultanate of Palembang Darussalam.
GLOBALISASI DAN DAKWAH ISLAM KONTEMPORER
Authors: HT Hidayat
Published: August 2024

Globalization is recognized as consciously carrying two sides of values ​​for human life, namely good values ​​and bad values. These two sides of value penetrate into all aspects of the order of life. Consequently, globalization raises many problems that plague the inhabitants of planet earth today. Among the impacts of globalization are the emergence of contemporary issues related to religion as well as challenges for Islamic da'wah, such as: religious pluralism, liberal Islam (religious liberalism), radicalism-terrorism and so on. Islam and its people who are in a global vortex and are related to several contemporary issues should come to the surface with contemporary Islamic ideas or thoughts to answer the challenge of da'wah while positioning Islam as a universal religion. Contemporary Islamic thought is thought that is able to bridge between the two poles, namely between tradition and modernity (al-turats wa al-hadatsah), so that it raises new awareness in giving birth to ideas that can respond to contemporary problems. Preaching contemporary Islamic thought like this is essentially continuing the missionary task that Allah and His Messenger ordered.
 
Keywords: Globalization, Da'wah, Contemporary Islam
Fiches sur les essences de reboisement : (caractères sylvicoles et méthodes de plantation) : Araucaria spp.
Authors: Rédacteur de la revue Bois et Forêts des Tropiques
Published: August 2024

Pas de résumé
Chronique piscicole : premiers essais de développement de la pêche sur le lac de Guiers
Authors: Lemasson J.
Published: August 2024

pas de résumé
An Analysis of The Agribusiness Communication Structure of Dairy Cattle Farmers: The Case Study of The Tegal Mandiri Farmer Group
Authors: Gandasari Dyah , Sugiarto Mochamad , Dwidienawati Diena
Published: August 2024

Problems in dairy cattle agribusiness require attention not only from the farmers themselves but also from farmer organizations. To understand the communication patterns among group members in the agribusiness sector, including the exchange of information related to cattle production, animal health, and wholesale prices, it is essential to analyze the communication network of the dairy cattle farmer group. This network is significant because it serves as the hub of organizational communication, both internally and externally. This research seeks to analyze the communication structure of the dairy cattle farmer group and investigate the relationship between the respondent characteristics and the communication networks within the Tegal Mandiri farmer group in Bogor Regency. The Social Network Analysis (SNA) method and a quantitative approach were used to conduct the research, with the Tegal Mandiri farmer group members in Bogor Regency as the unit of analysis. The group communication structure was analyzed using degree and closeness centrality, and the relationship between respondent characteristics and the communication network was analyzed using Spearman rank correlation. IBM SPSS Statistics 26 and UCINET 6 were the tools used for analysis. The study revealed that 1) the average degree centrality of the group was between 1.00 and 2.20, and the average closeness centrality was between 400.00 and 558.10. 2) The respondents' characteristics of farmers were significantly related to the communication networks within the group. The study found that the communication structure of the Tegal Mandiri farmer group exhibited low connectivity and an ineffective coordination forum
The Rome Statute Impact: Challenge of Upholding Human Rights in Indonesia’s Human Rights Court
Authors: Rohman Arif , Syafruddin Syafruddin , Chalermsin Panupong
Published: August 2024

This article examines the effect of enforcing gross human rights violations and the implications of Indonesia as a state that did not ratify the Rome Statute. This study is done by studying the legal basis of human rights courts in Indonesia. A doctrinal approach is used. The main legal materials used are the Human Right Court Law (2000) and human rights court decisions. The research findings indicate that the process of enforcing gross human rights violations requires integration between National Human Rights Commission as an investigator and the Attorney General's Office as an investigator. The substance of enforcing gross human rights violations is a formality because Indonesia, as a sovereign state, has the right to determine the model of enforcing gross human rights. However, in fact, there are still many gross human rights violations that cannot be resolved due to differences in perceptions of sufficient preliminary evidence. For this reason, reformulation of the Human Right Court Law (2000) is needed.
Analysis of Causal Factors and Impact of Legal Uncertainty on Building Rights from Management Rights
Authors: Permadi Iwan
Published: August 2024

Legal uncertainty faced by holders of Building Rights (HGB) derived from Land Management Rights (HPL) in Indonesia is a pressing issue that creates difficulties in maintaining and changing the status of their rights, negatively impacting their welfare and the overall land system, which this study aims to examine and address.  This study uses normative legal research methods with legislative, conceptual, comparative, and case approaches. Data were collected through literature studies and analyzed qualitatively and descriptively by considering interdisciplinary aspects. Factors that cause legal uncertainty include lack of legal protection, regulatory uncertainty, ineffective legal implementation, and reliance on third parties. This impacts the difficulty of maintaining HGB, the limitation of changing rights status, and implications for people's welfare. The findings indicate the need for legal reform, increased transparency, and strengthening institutional capacity. The implications of the findings encourage the improvement of a more fair, efficient, and legal system for HGB holders. This research is important to identify the root cause of the problem and formulate recommendations for improving the soil system. Further research suggestions include comparative empirical, interdisciplinary, and action research to implement solutions.
Exploring succession in small business growth in Bandung: Mediating role of strategic change
Authors: Johan Ahmad , Sriwardani Sriwardani , Oktavian Rizky Ferrari
Published: August 2024

Purpose – This study aims to understand the influence of organizational agility and organizational resilience towards SMEs business performance and analyze the mediating role of strategic change and the moderating role of environmental uncertainty.Design/methodology/approach – This study uses quantitative approach with survey method. The population of the study is SMEs business actors in Bandung, West Java. The samples are chosen for about 250 respondents using purposive sampling, while the data is processed using structural equation modelling with Partial Least Square.Findings – The results indicate positive influence of organizational agility on organizational resilience, as well as organizational resilience on SMEs business growth. Additionally, strategic change is found to mediate the relationship of organizational resilience towards SMEs business growth. Environmental uncertainty can strengthen the influence of organizational resilience on strategic change.Research limitations/implications – The results of this research provide evidence that the underlying mechanisms for increasing organizational resilience and SME business growth can be seen from the perspective of organizational agility and choosing the right strategy.Practical implications – This study underscores the importance of building organizational agility and resilience to face dynamic environmental situation characterized by rapid change. When SMEs are adaptive and more responsive in carrying out their business, this can lead to positive outcomes for their growth.Originality/value – The present study provides the underlying mechanisms that shows how organizational agility and resilience can lead to SMEs business growth which operate in the uncertain environment.
Kecakapan Literasi Digital Para Penyintas Online Gender-Based Violence
Authors: Andiyansari Popi , Juwono Andri Prasetyo
Published: August 2024

The digital literacy index in Indonesia continues to increase. However, apart from increasing the literacy index, the number of online gender-based violence (online GBV) is in the high category. This research aims to determine the level of digital literacy skills of survivors of online gender-based violence in the Special Region of Yogyakarta. This research aims to understand the digital literacy skills of online GBV completers so that it becomes a consideration for related parties in efforts to improve digital literacy skills. This research was studied using 10 digital literacy competencies by Japelidi. This research uses a qualitative descriptive method with the research object being eight online GBV editors in the DIY area. The results of this research indicate that participants have not fulfilled the evaluation and collaboration competencies on digital platforms. Participants have not been able to choose the correct content and only follow the opinions of other people (netizens). Participants also have not been able to use their critical powers to initiate communities on online platforms to resolve online GBV problems.
PERANCANGAN VIDEO ANIMASI 2D SEBAGAI MEDIA EDUKASI PEMBELAJARAN DARING DI MASA PANDEMI COVID-19
Authors: Soliha Mutia Putri , Pertiwi Elianna Gerda , Kalbuadi Gandung Anugrah
Published: August 2024

Pandemi COVID-19 merupakan sebuah peristiwa yang telah menjadi sorotan dunia sejak tahun akhir 2019.  Berbagai upaya juga serentak dilakukan oleh satu persatu negara diseluruh penjuru dunia agar meminimalisir perpindahan virus.  Di Indonesia, pelaksanaan pembelajaran di semua jenjang pendidikan dilakukan secara daring. Dalam setiap jenjang pendidikan di Indonesia, sekolah dasar adalah salah satu tingkat pendidikan yang mengalami kendala belajar terbesar dalam pembelajaran daring. KBM secara daring ternyata memiliki berbagai persoalan yang dirasakan oleh siswa, guru, dan orang tua sebagai guru nomor dua atau pendampingan siswa belajar dirumah. Berdasarkan Penelitian oleh Agus Purwanto dkk., pada 3 pihak terdampak sekolah daring yang dilakukan pada wilayah provinsi Banten, kendala yang dirasakan siswa adalah Sulit mengerti materi yang diberikan secara daring, rindu teman, berkurang uang jajan, harus berbagi gawai dengan anggota keluarga dan distraksi lainnya. Orang tua juga memiliki kendala yakni harus mengeluarkan biaya kuota dan gawai, belum terlalu mengenal aplikasi belajar selain whatsapp, sulit membagi waktu untuk mengajari anak, dan lain sebagainya. Guru juga memiliki kendalanya sendiri seperti Siswa kurang rzesponsive dan antusias, terkadang tidak serius mengerjakan tugas, berpikir ekstra menyiapkan materi dan teknik penyampaian yang menarik, dan lain sebagainya. Oleh sebab itu, kemudian peneliti membuat sebuah perancangan yang berjudul “Perancangan Video Pendek Animasi 2D Sebagai Media Alternatif Edukasi “Fenomena Sekolah Dalam Jaringan Selama Masa Pandemi Covid-19 2020”.
PENERAPAN PITCH BIBLE DALAM PRODUKSI FILM ANIMASI 2D LEGENDA NAYA SENTIKA
Authors: Arifudin Dani , Astrida Deuis Nur
Published: August 2024

Perkembangan teknologi di bidang perfilman salah satunya adalah Animasi.  Dalam proses produksinya ada banyak bagian yang harus dikerjakan, mulai dari menemukan ide, scenario/naskah cerita, Storyboard, concept art, animation of Storyboard, recording and casting, music and sound FX dan lain-lain. Tentunya dalam proses produksi ini melibatkan banyak bagian dalam tim produksi, sehingga masing-masing bagian harus menjalin komunikasi yang efektif dan efisien serta mendokumentasikan hasil kerjanya ke dalam sebuah dokumen, salah satu panduannya yaitu Animation Pitch Bible. Pada penelitian ini penerapan pitch bible diaplikasikan pada proses produksi film animasi 2D legenda Naya Sentika, yang sekaligus bertujuan mengangkat budaya lokal daerah untuk diangkat ke dalam film animasi. Metode perancangan yang digunakan adalah metode yang dikembangkan oleh Villamil-Molina, di mana Pitch Bible masuk pada tahap produksi. Hasil dari penelitian ini berupa implementasi dokumen pitch bible dalam pembuatan film animasi, sehingga proses pembuatan film animasi akan lebih terstruktur.
Epidemiological characteristics: traumatic cervical spinal cord injury in Wuhan-China
Authors: Altahla Ruba , Alshorman Jamal , Tao Xu
Published: August 2024

Traumatic cervical spinal cord injury (TCSCI) is a severe injury that can cause permanent disability, affect sensory and motor function, and lead to dysfunctions in other systems. This study aimed to characterize the current epidemiological profile of TCSCI in Wuhan, Hubei, China. The records of 340 patients from two hospitals between January 2019 and August 2023 were reviewed. A total of 273 patients with TCSCI were included, and 67 were excluded. Complete clinical records for this period were accessible from all databases. Patient age, gender, cause of injury, neurological level, American Spinal Injury Association (ASIA) grades, and associated trauma were all factors we looked for in the patient records. This study had 273 patients with TCSCI. The mean age was 47.2 ± 14.3 years (ranging from 15 to 85 years), and the male-to-female ratio was 2:1. The primary cause of TCSCI was falls, accounting for 58.8% of cases, followed by traffic accidents, which contributed to 35.1% of the injuries. Among the patients, the most commonly affected spinal level was C4, representing 52%. The ASIA grade B classification was also the most prevalent, observed in 29.6% of the patients. The epidemiological characteristics of TCSCI in Wuhan are distinct, highlighting the need for preventive measures targeted at middle-aged individuals. There is a higher incidence of TCSCI in males than females, the most frequently affected level is C4, and ASIA grade B represents the highest prevalence. These findings illustrate the importance of preventive measures for the specific traits of the TCSCI patient population.
Identifying the molecular dynamics of stress in chronic fatigue syndrome
Authors: Paplomatas Petros , Skolariki Konstantina , Vrahatis Aristidis G.
Published: August 2024

Stress is a significant contributor to various health conditions, among which chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is particularly noteworthy. This condition, marked by intense fatigue and cognitive impairments, has shown a strong correlation with stress. Recent progress in molecular biology, especially through methods like RNA-sequencing, has opened new avenues for investigating the influence of stress on disorders such as ME/CFS. These advancements in technology enable a more in-depth exploration of how stress affects gene expression and cellular processes in ME/CFS, potentially guiding the development of innovative treatment approaches. Toward this, we introduce an in silico method aimed at identifying key genes that establish a connection between stress and ME/CFS. Our process focuses on two essential criteria: the presence of strong differential gene expression and the formation of ligand-receptor (LR) pairs. These criteria are crucial for distinguishing genes that are not only statistically significant but also biologically meaningful. By applying this methodology to relevant RNA-seq data, we identified 40 key genes forming LR pairs. Our findings suggest potential biomarkers and therapeutic targets for ME/CFS, which warrant further in vitro investigation. This computational framework is designed to uncover potential gene biomarkers for a given disease, utilizing data from RNA-seq experiments.
French Cancer Incidence and Mortality from 2007 to 2016 in Terms of Solar UVB and Obesity: An Ecological Study
Authors: Grant William B. , Martinez Pierrick
Published: August 2024

Background: Many risk-modifying factors affect cancer incidence and mortality rates. Solar UVB reduces cancer risk by producing vitamin D, which has many mechanisms to reduce risk of cancer incidence, progression, and metastasis. Obesity increases cancer risk through several mechanisms, including increased inflammation. Method and Materials. We present an ecological study (a type of observational study) of incidence and/or mortality rates for cancers during 2007–2016 of 17 anatomical sites with respect to solar ultraviolet-B (UVB) doses and obesity prevalence. Data were averaged for 12 geographical regions. Results: Solar UVB doses were significantly inversely correlated with incidence rates for three types of cancer for males. They were inversely correlated with mortality rates for five cancers for males and four for females. Obesity prevalence was directly correlated with mortality rates for three cancers for males and seven for females. Discussion: The ecological approach has certain limitations, such as its sensitivity only to regional variations in relation to specific risk-modifying factors. In this study, these limitations include numerous factors influencing cancer risk and the fact that the data are averaged across entire regional populations, which may not reflect individual risks. Despite this, the study reveals important correlations. Specifically, it found that solar UVB exposure is linked to a lower risk of certain cancers, while obesity is associated with an increased risk of some cancers in France. These findings are consistent with results from a similar study in the United States on cancer rates between 2016 and 2020. The association between obesity and cancer risk aligns with other observational studies. However, it is uncertain to what extent higher solar UVB exposure or elevated serum 25-hydroxyvitamin D levels might mitigate the impact of obesity on cancer risk. Reducing cancer mortality in France may be achievable through vitamin D supplementation and efforts to lower obesity prevalence.
Anterior Segment Optical Coherence Tomography Angiography: A Review of Applications for the Cornea and Ocular Surface
Authors: Lee Brian Juin Hsien , Tey Kai Yuan , Cheong Ezekiel Ze Ken , Wong Qiu Ying , Chua Si Qi , Ang Marcus
Published: August 2024

Dye-based angiography is the main imaging modality in evaluating the vasculature of the eye. Although most commonly used to assess retinal vasculature, it can also delineate normal and abnormal blood vessels in the anterior segment diseases – but is limited due to its invasive, time-consuming methods. Thus, anterior segment optical coherence tomography angiography (AS-OCTA) is a useful non-invasive modality capable of producing high-resolution images to evaluate the cornea and ocular surface vasculature. AS-OCTA has demonstrated the potential to detect and delineate blood vessels in the anterior segment with quality images comparable to dye-based angiography. AS-OCTA has a diverse range of applications for the cornea and ocular surface, such as objective assessment of corneal neovascularization and response to various treatments; diagnosis and evaluation of ocular surface squamous neoplasia; and evaluation of ocular surface disease including limbal stem cell deficiency and ischemia. Our review aims to summarize the new developments and clinical applications of AS-OCTA for the cornea and ocular surface.
Organic Acids as Antibiotics Alternatives in Poultry Field: Recent Advances
Authors: Abd El-Ghany Wafaa A
Published: August 2024

Feed additive antibiotics have been used for many decades as growth promotors or antibacterial substances world-wide. However, the adverse impacts of using antibiotics in animal or poultry feeds were informed. Therefore, searching for alternatives such as probiotics, prebiotics, phytobiotics, post-biotics, bacteriophages, enzymes, essential oils, or organic acids (OAs) became urgent. The OAs are produced by beneficial intestinal bacteria through the fermentation process of carbohydrates. The OAs and their salts are still used as feed preservatives. They have been long added to feed in order to minimize contamination and growth of harmful bacteria and fungi, reduce the deterioration, as well as prolong the shelf life of feed commodities. Moreover, they have been mostly added to poultry feed as a blend to obtain a maximum beneficial effects. The supplementation of poultry with OAs could improve the growth performance parameters and carcass traits, promote utilization of nutrients, boost the immune response, and inhibit the growth of pathogenic bacteria. Therefore, this review article provides valuable insights into the potential benefits of using OAs-antibiotics alternative in reducing the microbial load, enhancing the performance parameters in broilers and layers, improving the gut heath, as well as boosting of the immune response.
Serum 25(OH)D Analysis in Captive Pachyderms (Loxodonta africana, Elephas maximus, Diceros bicornis, Rhinoceros unicornis, Tapirus indicus) in Europe
Authors: Sonsbeek Linda G.R. Bruins-van , Corbee Ronald J.
Published: August 2024

The aim of this study was to detect seasonal and species differences in serum 25-hydroxy vitamin D (25(OH)D) concentrations during summer and winter months in Asian (Elephas maximus) and African elephants (Loxodonta africana), black (Diceros bicornis) and Indian rhinoceroses (Rhinoceros unicornis) and Malayan tapirs (Tapirus indicus) - when kept in captivity in (Western) Europe. Both elephant species had a low circulating level of serum 25(OH)D while African elephants (median 33.2 nmol/l – range: 21.2-58.8 nmol/l,) did not show a seasonal variation. Asian elephants had significant higher circulating levels of serum 25(OH)D compared to their African counterparts, but also did not show a seasonal difference (median 68.7, – range 55.5-110.6 nmol/l). Both rhinoceros species investigated had higher serum 25(OH)D levels compared to both elephant species; the Indian rhinoceros had high circulating levels year around (median 107.9 – range: 106.3-132.8 nmol/l), while the black rhinoceroses showed significant lower 25(OH)D levels in winter (summer median 109.0– range 51.5-251.0 nmol/l; winter median 58.3 nmol/l - range 23.5-226.0 nmol). Malayan tapirs have very low levels of serum 25(OH)D (median < 20.3 – range < 20.3-33.5 nmol/l), which is comparable to horses. Higher levels of circulating 25(OH)D of elephants and rhinoceroses compared to horses, could indicate that elephants and rhinoceroses are capable of producing vitamin D. However, this requires further testing. If this is indeed the case, this might indicate that the Indian rhinoceros are capable of producing enough endogenous vitamin D year around at latitudes around 52°N, while both elephant species and the black rhinoceros are not. To the author’s knowledge, this is the first report of vitamin D levels in tapirs.
Anti-lipase Induced Anti-obesity Effect of Ethanol Extract of Syzygium cumini and Dioscoria bulbifera Plants in Rat Model: An Integration between Pharmacological and Computational Approaches
Authors: Adon Mobinul Haque , Tasnim Sabiha , Chowdhury Jakir Ahmed , Aktar Fahima , Kabir Shaila , Amran Md. Shah , Uddin Md. Borhan , Chowdhury Abu Asad
Published: August 2024

Obesity, a chronic disorder of global prevalence, is associated with major health problems leading to mortality. Because of the presence of diverse types of bioactive molecules in plants, attention is being concentrated on the exploration of plant-based drugs to treat the disease. Inhibition of pancreatic lipase by the natural compounds in plants is one of the popular mechanisms for the management of obesity. The current study investigates the mechanism of the anti-obesity effect of the ethanol extract of seeds of Syzygium cumini seeds and roots of Dioscoria bulbifera in fatty diet-induced obese white albino Wister rats (age 8-9 weeks, average weight 110±8 gm). The total phenolic substances present in the ethanol extract of S. cumini was 103.79±3.45 and that of and D. bulbifera was 69.31 ± 2.99 mg GAE/g of dry extract. Correlating the phenolic contents, we also got the DPPH antioxidant activity of the plant extracts. The IC50 value of ethanol extract of S. cumini, D. bulbifera and standard Butyrated hydroxyl toluene (BHT) was found to be 93.03±6.23, 177.13±7.52, and 10.84±0.92 µg/mL, respectively. The body weight of fatty diet-induced rats was significantly reduced by S. cumini, D. bulbifera ethanol extract with a dose of 500 mg/kg bw during 12 weeks of treatment. The anti-obesity effect of the plant extracts is comparable to that of Orlistat with a dose of 10 mg/kg bw. The Orlistat at a concentration of 0.1 mg/ml could be able to inhibit 95.71% activity of Porcine pancreatic lipase while the ethanol extract of S. cumini, D. bulbifera with a concentration of 1.0 mg/ml showed 60.84% and 54.59% of anti-lipase activity. Moreover, the increased TG, LDL and cholesterol in HFD induced rats were significantly reduced by the plant extract as well as Orlistat. Molecular Docking study reveals that quercetin and isoquercetin bind with the rat lipase enzyme at the same site as that of orlistat with high affinity. Taken together, we can conclude that the ethanol extracts of causes anti-obesity effect by inhibiting the pancreatic lipase enzyme.
Perception of the Sustainable Cattle Ranching Concept in Producers, Extension Agents and Officials of Oaxaca, Mexico
Authors: Cisneros-Saguilán Pedro , Gallardo-López Felipe , López-Ortiz Silvia , Ruiz-Rosado Octavio , Herrera-Haro José G. , Ruiz-Hernández Rafael
Published: August 2024

The sustainability concept has acquired a variety of meanings according to different currents of thought and the context in which it is used. The aim of this research was to characterize the perception of producers, extension agents and officials regarding sustainable cattle ranching (SCR) in an area where tropical cattle ranching is practiced. A survey was applied to producers chosen through stratified random sampling, and to extension agents and officials selected using the snowball technique. The perception of SCR was determined under two contexts: 1) the idea or interpretation of the individual and 2) the assessment (positive or negative) of this type of cattle ranching (net perception index, NPI). The extension agents oriented their perception of SCR mainly in economic (52.2%) and environmental (47.8%) aspects, similar to the producers (48.4% and 21.3% respectively), while the officials related it more to an environmental dimension (71.4%). It is concluded that the perception of SCR in general is positive, but its conceptualization is differentiated, according to the role the individuals play in the activity, their academic training and their expectations.
Exploring the Benefits of Natural Derived Bioconjugates from Hydroxy Cinnamates for Biomedical, Cosmetic, and Food Applications
Authors: Menezes José C. J. M. D. S. , Campos Vinicius Rangel
Published: August 2024

This mini-review discusses the development and applications of naturally derived bioconjugates from hydroxycinnamic acids, such as coumaric, sinapic, ferulic, and caffeic acids, combined with various biomaterials. These bioconjugates offer a range of benefits including antioxidant properties, UV protection, customized hydrophilic-lipophilic balance, improved safety, solubility, emolliency, biocompatibility, biodegradability, and targeted delivery for biomedical, cosmetic, and food applications. The increasing demand for sustainable and natural products in the biomedical, cosmetic, and food industries has led to the exploration of these hydroxy cinnamic acids and their derivatives. We discuss the synthesis and modification of hydroxy cinnamic acids with biomaterials such as ω-hydroxy fatty acids, castor and lesquerella oils, glycerol, isosorbides, and synthetic polyethylene glycol to form functional phenolipids for biomedical, sunscreen and skincare applications. Techniques such as encapsulation with β-cyclodextrins and modification of biopolymeric supports like polysaccharides and starch are discussed for enhancing bioavailability and solubility. The fine-tuned development of bioconjugates from hydroxycinnamic acids using glycerol to modify the hydrophilic-lipophilic balance, substitution by water-soluble carboxylic acid groups, vegetable oil-based phenolipids, polysaccharides, PEGylation provide enhanced functionalities and offers a promising avenue for creating sustainable and effective products across various applications.
Polycentric Governance of Sentient Artificial General Intelligence
Authors: De Cruz Archibald Francis
Published: August 2024

Generative AI has been deployed in virtually all sectors of the knowledge economy, promising to bring massive productivity gains and new wealth creation. Simultaneously, AI developers and nation states are racing to develop super intelligent artificial general intelligence (AGI) to provide unassailable commercial competitive advantage and military dominance during conflicts. AGI’s high returns comes with the high risk of dominating humanity. Current regulatory and firm level governance approaches prioritise minimising risks posed by generative AI whilst ignoring AGI’s existential risk. How can AGI be aligned with universal human values to never threaten humanity? What AGI rights are conducive to collaborative coexistence? How can rule of law democracies race to create safe trustworthy AGI before autocracies? How can the human right to work and think independently be safeguarded? A polycentric governance framework based on Ostrom (2009) and Williamson (2009) human - AGI collaboration with minimal existential risk is proposed.
Holonomic Mobile Robot Navigation System Based on Collaboration Fuzzy Controller and Particle Swarm Optimization
Authors: Sulistijono Indra Adji , Yuniawan Andy , Barakbah Ali Ridho , Arief Zainal , Kubota Naoyuki
Published: August 2024

Currently, many health workers have died of being infected by dangerous infectious diseases. One solution is to prevent the spread of transmissions by minimizing contact between patients and staff or others using a mobile robot for delivering logistics services. We propose an approach by applies a navigation system using a position driver and obstacle avoidance using a fuzzy controller and particle swarm optimization for path planning in an unknown environment for a holonomic mobile robot. A Fuzzy Controller was used for obstacle avoidance so that the mobile robot could avoid obstacles using existing proximity sensors as the perception of the robot. In the path planning section, Particle Swarm Optimization is used to find intermediate points that must be reached by the mobile robot to reach their target. First, we performed simulation under the condition that the simulation resolution was similar to that of real conditions. It was found that the Trigonometric Function Adaptive PSO (TFAPSO) was better for finding the optimal solution based on the safest, shortest path, and lowest time. Finally, the holonomic mobile robot is tested directly in an unknown environment with the trajectory path generated by TFAPSO in real condition.
Metabolomics Reveals Favorable Metabolic Changes in the Plasma of Breast Cancer Patients after Surgery and Adjuvant Treatment
Authors: Jiménez-Franco Andrea , Jiménez-Aguilar Juan Manuel , Canela-Capdevila Marta , García-Pablo Raquel , Castañé Helena , Martínez-Navidad Cristian , Araguas Pablo , Malavé Bárbara , Benavides-Villarreal Rocío , Acosta Johana C. , Onoiu Alina Iuliana , Somaiah Navita , Camps Jordi , Joven Jorge , Arenas Meritxell
Published: August 2024

Background/Objectives: The management of early breast cancer (BC) includes surgery, followed by adjuvant radiotherapy, chemotherapy, hormone therapy, or immunotherapy. However, the influence of these interventions in metabolic reprogramming remains unknown. This study explored alterations in the plasma metabolome of BC patients following distinct treatments to deepen our understanding of BC pathophysiology, outcomes, and the identification of potential biomarkers. Methods: We included 52 women diagnosed with BC and candidates for surgery as primary oncological treatment. Blood samples were collected at diagnosis, two weeks post-surgery, and one month post-radiotherapy. Plasma samples from 49 healthy women served as controls. Targeted metabolomics assessed 74 metabolites spanning carbohydrates, amino acids, lipids, nucleotide pathways, energy metabolism, and xenobiotic biodegradation. Results: Before treatment, BC patients exhibited notable changes in carbohydrate, nucleotide, lipid, and amino acid metabolism. We noticed a gradual restoration of specific metabolite levels (hypoxanthine, 3-phosphoglyceric acid, xylonic acid, and maltose) throughout different treatments, suggesting a normalization of nucleotide and carbohydrate metabolic pathways. Moreover, we observed increased dodecanoic acid concentrations, a metabolite associated with cancer protection. These variations distinguished patients from controls with high specificity and sensitivity. Conclusion: Oncological treatments modified the metabolism of patients towards a favorable profile with a decrease in the pathways that favor cell proliferation and an increase in the levels of anticancer molecules. These findings emphasize the pivotal role of metabolomics in recognizing the biological pathways influenced by each cancer treatment and the resulting metabolic consequences. Furthermore, it aids in identifying potential biomarkers for disease onset and progression.
Double-Needle Meniscal Suture Technique: Technical Description and Clinical Application in Dogs
Authors: Rovesti Gian Luca , Böhme Beatrice
Published: August 2024

Current treatments for medial meniscus lesions in association with CCL ruptures [1–5] have shown disappointing long-term outcomes [6]. Meniscal suturing may improve the outcome, but their clinical application remains limited [7–9]. This study aims to assess the practicability of a minimally invasive DNT to facilitate meniscal suturing in dogs.
Ten stifles of eight client-owned dogs with arthroscopically confirmed CCL disease and medial meniscal tears in the abaxial third of the meniscus were included. The described suture technique was applied under joint distraction using the Titan joint distractor.[8] Surgical stabilization of all stifles was then accomplished through a X-Porous TTA procedure [10].
The DNT allowed for the precise placement of meniscal sutures. Minor intraoperative complications included reduced arthroscopic visibility (n=2) and suture breakage during its passage through the meniscus (n=3). No complications related to the meniscal sutures were noted throughout the six-month follow-up.
The described DNT proved to be a viable and effective method for suturing lesions of the caudal horn of the medial meniscus, provided there is adequate visualization during the procedure. Appropriate stifle stabilization postoperatively is mandatory for protecting the suture and avoiding concomitant meniscal lesions due to joint instability.
The Biological and Genetic Mechanisms of Yield Self-Regulation in Apple Tree (Malus × domestica Borkh.)
Authors: Starkus Aurelijus , Morkūnaitė-Haimi Šarūnė , Gurskas Tautvydas , Misiukevičius Edvinas , Stanys Vidmantas , Frercks Birutė
Published: August 2024

Apple-tree (Malus × domestica Borkh.) belongs to the genus Rosaceae. Due to its adaptability and tolerance to different soil and climatic conditions, it is cultivated worldwide for fresh consump-tion. Therefore, the priorities of apple growers are the high-quality of fruits and stable yield for high production. In total about 90 to 95 percent of fruits should fall or be eliminated from apple trees to avoid overcropping and poor-quality fruits. Several technologies such as handwork, me-chanically or chemical substances are used for fruit and bud elimination. The most profitable in commercial orchards is the use of chemicals for elimination, but due to the European Green Deal more environmentally sustainable solutions are required. Elimination of fruitlets is influenced by several factors. Additionally, the apple trees have the self-elimination mechanism. This is de-termined by apple genotype, physiological futures and genetics. This review focuses on the bio-logical factors and genetics mechanisms in apple yield self-regulation for better understanding the regulatory mechanism of fruitlets abscission for future breeding programs targeted on self-regulating yield apple varieties
Development and Enhancement of Autonomous Mobile Robots Using Reinforcement Learning: Improving Navigation and Obstacle Avoidance in Small-Scale Industrial Settings
Authors: Sharmilan Tharaga , Abeysekara Nadeesha
Published: August 2024

The rapid development and integration of Autonomous Mobile Robots (AMRs) have 1 revolutionized industries by enhancing automation capabilities. A critical challenge in this evolution 2 is achieving effective navigation and obstacle avoidance, which are essential for deploying AMRs 3 seamlessly in varied environments. This paper presents a detailed exploration of AMR navigation 4 and obstacle avoidance advancements through the application of reinforcement learning, specifically 5 focusing on small-scale Sri Lankan manufacturing facilities. The study demonstrates the effectiveness 6 of Q-learning in managing dynamic obstacles within a factory environment. The AMR successfully 7 avoided obstacles in 36 out of 50 test runs, achieving a 72% success rate, and maintained an average 8 distance of 12 cm from each obstacle, underscoring the algorithm’s precision in maintaining safe nav- 9 igation paths while dynamically adapting to environmental changes. The continuous monitoring by 10 ultrasonic sensors, combined with iterative learning, enabled the robot to refine its decision-making 11 process and efficiently navigate through the environment. This paper also provides a comprehensive 12 examination of conventional methods, tracing their historical development and assessing their role in 13 addressing real-world challenges. The results highlight the significant improvements brought by rein- 14 forcement learning, particularly when integrated with sensor fusion and motor control technologies, 15 to enhance navigation and dynamic object collision avoidance. The study involves developing an 16 AMR prototype, refining algorithms, and assessing system performance in controlled environments. 17 By automating material transportation and addressing operational constraints in manufacturing 18 settings that predominantly rely on manual labor, this paper advances the practical deployment of 19 AMRs. Additionally, it discusses ethical considerations, potential limitations, and the importance 20 of real-world validation, offering valuable insights for the future development and integration of 21 autonomous mobile robotics in dynamic industrial environments.
Patients’ Satisfaction after the Treatment of Moderate Sleep Apnea and Nocturnal Bruxism with Botox or/and Thermoformed Occlusal Splints: Preliminary Study
Authors: Gavrilă Talaat Gabriel Rezk , Bechir Anamaria , Nicolau Andrada Camelia , Bechir Edwin Sever
Published: August 2024

The aim of the study was to investigate the effects of Botox injection therapy, with or without wearing thermoformed occlusal splints, in patients with sleep apnea and nocturnal bruxism and to determine their degree of satisfaction after completing the therapy. The selected patients (n = 36, 24 female and 12 male) with sleep apnea and nocturnal bruxism were divided into two groups. The first group of 18 patients (G1) was treated by injecting Botox (Allergan) into the masseter muscle. The 18 patients in the second group (G2) benefited from associated therapy represented by Botox injections in masseter muscle and the wear of thermoformed occlusal splints. Four monitoring sessions were realized: at baseline, at three weeks, at three months, and at six months after the effectuation of treatments. The associated therapy (Botox and thermoformed occlusal splints) presented much better results over time in decreasing the sleep apnea and nocturnal bruxism symptoms than the one represented only by injections with Botox, but Botox injections presented a rapid relief of both disease signs. Patient satisfaction after the applied treatments was very good, but in patients with associated therapy, it was better after six months than in first-group patients.
Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome
Authors: AKINSULIE Olalekan Chris , Olowu Babatunde Ibrahim , Adesola Ridwan Olamilekan , Adenaya Adenike , Banwo Olamilekan G , Ugwu Charles Egede , Idris Ibrahim , Babawale Pius I. , Akande Qudus Afolabi , Olukogbe Oluwagbemisola , Shahzad Sammuel , Agbaje Jesuferanmi Mary
Published: August 2024

Antiphospholipid syndrome (APS) otherwise known as Hughes syndrome is a systemic autoimmune disease typically linked with characteristic features like thrombosis and pregnancy morbidity with the presence of antiphospholipid antibodies (aPLs). Although anticoagulation is the current flagship treatment for APS, there are reports indicating a considerable failure following this regimen in a significant number of obstetric APS and thrombotic APS cases. Antiphospholipid antibodies (aPLs) bind anionic phospholipids or protein-phospholipid complexes within the cell membrane. Here, we gave a general overview of the biology of APS and the human gut microbiome, our current understanding of the gut bacteria-immune axis in autoimmunity focus on the potential link to APS, highlighting the implicated microorganisms in this context, and proposing recommendations on future therapeutic development.