bluuebunny/crossref_metadata_2025 huggingface dataset:
Micro-Influencer Celebrity’s Communication Strategy in Brand Promotion
Authors: Silalahi Ayuphita Tiara
Published: June 2021

The research analyzed the role of Instagram influencers, especially those who fell into the category of microinfluencers, and the impacts they generated through effective communication strategy in promoting local brands in Indonesia. The exploratory study adopted a qualitative research design by collecting primary data through indepth interviews with selected micro-influencers, local brands marketers, and an Influencer marketing strategist. While secondary data was gathered from both offline and online available documented literatures. Results were then categorized using Creswell’s six-stage analysis method in order to produced themes. Findings show that Instagram is a preferred social media platform in Indonesia for local companies to promote their brands by selecting micro-influencers as part of the communication strategy. Four distinctive characteristics outline the themes of Instagram micro-influencer that are seen as primary factors for the brands to utilize in ensuring effective brands’ communication strategy. The research concludes that different methods of delivering a brand’s messages can be utilized to achieve the brand’s communication goals and the high intensity of engagement between the influencer and their followers is the core strength for the success of the communication activity. This is a quality seeks by both brands and influencer agencies to ensure successful brands’ communication strategy.
"Itu Sebuah Skandal": Lexical and Sociocultural Interpretation in Critical Discourse Analysis of Fadli Zon's Tweet
Authors: Luke Joice Yulinda , Widyastuti Surtikanti Monika , Sumarlam Sumarlam
Published: June 2021

There were two objectives of the research. The first was to analyze the word ‘scandal’ from textual analysis (micro-level) and sociocultural analysis (macro-level). To analyze the findings, the research made use of Norman Fairclough’s model as the basis of critical discourse analysis. The research was qualitative, which tended to use inductive as the approach. There were 23 informants who participated in the survey and the FGD. They were selected purposively based on their profession and the workplace areas. The data were the four of Fadli Zon’s tweets containing the word ‘scandal’ and its context, which was available in some online media. Research content based on the textual analysis (microanalysis) shows that the text structure is short and directly conveys Fadli Zon’s criticism or negative assumptions toward any policies of government issues. Besides, the macro analysis indicates Fadli Zon has a dominant power to utter the negative judgments toward the government regarding the position in the government structure as one of the leaders in the Indonesian House of Representative. Substantially, the use of specific terms’ scandal’ overall illustrates the negative opinions and indicating declining trust in the policymakers on certain governmental issues. The use of cynicism, sarcasm, and satire styles colors Fadli Zon’s tweets that are also accompanying the overused of ‘scandal’ word. The analysis based on the dimension of discourse practice (micro-level) indicates that using the word ‘scandal’ in Fadli Zon’s tweets is cynical according to the public opinions. The analysis based on the social-cultural practice dimension (macro-level) indicates that Fadli Zon is one Indonesian politician who is often opposed to the Indonesian government policies.
Ensuring the confidentiality of information about a person involved in criminal proceedings: selected issues and solutions
Authors: Talyzina Ya. O. , Titko I. A.
Published: June 2021

The article highlights the problem of practical implementation of such a security measure that can be applied to participants in criminal proceedings, such as ensuring the confidentiality of personal information. It is analyzed the views diversity of investigators, prosecutors, judges and lawyers on the algorithm of application of ensuring the personal data confidentiality, on the issue of storage of resolutions (decisions) on the application of this security measure in criminal proceedings.
The practice of conducting procedural actions in court with persons whose personal data have been changed is studied separately. The peculiarities of interrogation, identification with protected participants of criminal proceedings in the mode of videoconference and in a closed court session are studied. Previous attempts to solve this problem by developing a Model Instruction on conducting court proceedings with witnesses, victims and other participants in criminal proceedings, in respect of whom security measures have been taken, are considered.
According to the analysis results of the domestic legislation on security of participants in criminal proceedings and identification of gaps, after conducting a survey of current investigators, prosecutors, judges and lawyers, the generalization of modern practice of criminal proceedings with the participation of protected persons is made.
The purpose of this research is to formulate proposals for a unified and mandatory for all participants in criminal proceedings procedure for working with persons whose personal data are changed for security purposes at all stages of criminal proceedings.  
The expediency of enshrining at the bylaw level in a separate normative legal act an algorithm for carrying out procedural actions in court with participants in criminal proceedings, which would meet the requirements of current legislation, including the provisions of the Data Summary constituting a state secret, is substantiated.
International legal obligations of Ukraine for the conservation and res-toration of natural ecosystems and the implementation of the ecosystem ap-proach
Authors: Suietnov Ye. P.
Published: June 2021

The article analyzes the provisions of the multilateral and bilateral international legal treaties of Ukraine aimed at the conservation and restoration of natural ecosystems and the implementation of an ecosystem approach, which is a strategy for the integrated management of land, water and living resources that promotes conservation and sustainable use in an equitable way.Based on the conducted research, it is concluded that these issues are among the most important and relevant at the international legal level, therefore, our state, having assumed relevant obligations in this area, should focus its efforts to their proper reflection in the national regulatory and legal field and their practical realization.It is hoped that in the near future, the outlined issues will receive increased attention both at the level of environmental legislation and in practical terms, because according to the Law of Ukraine «On the Basic principles (strategy) of state environmental policy of Ukraine for the period up to 2030» dated 28.02.2019, which now has the status of a leading pointer in the environmental sphere, the goal of state environmental policy is to achieve a good state of the environment by introducing an ecosystem approach to all areas of socio-economic development of Ukraine to ensure the constitutional right of every citizen to a clean and safe environment, introduction of balanced nature management and conservation and restoration of natural ecosystems.
Strategizing of the Human Resources Development: Main Elements and Stages
Authors: Novikova Irina
Published: June 2021

Introduction. The welfare of the state depends on the efficient use of labor resources. The time gap between the economy’s need for special personnel and their professional training and adaptation reduces their efficiency and requires a methodologically precisely developed tool, i.e. a strategy. This is especially relevant due to the increasing uncertainty in the economic and social development, the emergence of new opportunities and threats associated with digitalization, robotization, globalization and world epidemics, etc. Study objects and methods. The present research was based on the theory of strategy and methodology of strategizing developed by Foreign Member of the Russian Academy of Sciences, Dr.Sci(Econ.), professor V.L. Kvint. The ultimate goal of implementing any strategy (global, national, regional, sectoral, corporate, and personal) according to the methodology of V.L. Kvint is to improve the quality and standard of human life. Results and discussion. The main elements are: strategic opportunities for the development of labor resources, strategic interests, strategic priorities for the development of labor resources, competitive advantages of labor resources, mission of development of labor resources, vision of development of labor resources, efficiency of development of labor resources. There are seven main stages. The preliminary (organizational) stage includes the emergence of an idea about the need for a strategy, the choice of a strategy methodology and a team of strategists. The first step involves identifying strategic opportunities based on identifying trends. The second stage determines interests and strategic priorities, while the third stage defines competitive advantages. The fourth stage features the mission of human resources development. The fifth stage is aimed at the vision of the development of labor resources, the sixth concentrates on efficiency, and the seventh is the implementation of the strategy. Conclusion. Effective and efficient strategizing of the development of labor resources requires strict adherence to the methodology and consistent passage of all the necessary stages.
Transition Metal-mediated Uncaging Chemistry in Prodrug Design
Authors: Shu Hai Yang , De Zhu Ren , Wu Jing , Liu Xin Hua , Shi Jing Bo
Published: June 2021

Uncaging chemistry catalyzed by transition metals is developed from deprotection reactions
and metal-organic catalytic reactions. Also, it has the characteristics of high efficiency, simplicity
and rapidity in the living biological system. In the past decade, metal encapsulation systems (such
as nanoparticles) and metal complexes have been developed to reveal the reactivity of transition metals
(including palladium, ruthenium, and gold) in biological systems. Metal nanostructures provide
huge possibilities for targeted drug delivery, detection, diagnosis and imaging. So far, palladium,
ruthenium and gold nano-architectures have dominated the field, but there are some problems that
hinder their wide application in clinical practice. In this review, based on palladium, ruthenium, gold
and their complexes, the application of prodrug design through uncaging reaction has been widely
discussed.
Cardiopulmonary resuscitation and the RECOVER guidelines at the Faculty of Veterinary Medicine, Ghent University
Authors: Verdoodt F. , Roggeman T. , Polis I.
Published: June 2021

The implementation of the RECOVER guidelines at the Small Animal Department, Faculty of Veterinary Medicine of the Ghent University was assessed by performing both a cross-sectional research and a study on the impact of training. During a six-month prospective cross-sectional study, 39 patients, which underwent cardiopulmonary resuscitation (CPR), were recorded. This corresponds with an incidence of 1.8% of all hospitalized patients that underwent CPR during the same period. Of these cases, 32 were included in the statistics. Return of spontaneous circulation (ROSC) was obtained in eleven patients (34.3%), but only one dog (3.1%) survived to discharge. In this study, an association between hemolymphatic disease as concomitant disease and not obtaining ROSC was shown. Subsequently, four cardiopulmonary resuscitation (CPR) training sessions were organized. The confidence of the participants was evaluated before and after these training sessions and showed a significant increase after the training session. With increased training of all personnel and students involved in CPR efforts, the aim of this study was to increase positive outcomes and to achieve a more standardized CPR protocol.
Oak leaf (Quercus spp.) intoxication in a sheep
Authors: De Backer S. , Chiers K. , Van Brantegem L.
Published: June 2021

A twenty-year-old ewe presented with acute lateral decubitus, tremor and dyspnea, followed by death. Post-mortem examination revealed a large amount of oak leaves in the rumen, reticulum and omasum. The duodenum had a focal hemorrhagic content and multifocal hemorrhages were present in several organs. Histopathological examination of the kidneys showed characteristic lesions of oak intoxication, such as intratubular hemorrhage, tubular degeneration and necrosis. This case report illustrates the importance to include oak intoxication in the differential diagnosis of acute death in sheep and the value of post-mortem and histopathological examination.
Oorlogspaarden
Authors: De Smet J.
Published: June 2021

Ook tijdens de Eerste en zelfs de Tweede Wereldoorlog bleven paarden uiterst belangrijk. Trekpaarden en ook kruisingen met ezels, vooral muildieren, werden ingezet om zware artilleriestukken en ander wapentuig naar de frontlinies te trekken en te dragen. Ook voor andere logistieke taken werden ze gebruikt, bij de levensnoodzakelijke bevoorrading van troepen in loopgraven, evengoed als in snel oprukkende (of aftrekkende) bewegingen. In bewegingsoorlogen konden paarden ingezet worden bij verkenningsopdrachten. Dit tweede deel over oorlogspaarden begint met een korte beschrijving van de strak gereglementeerde verzorging van paarden in vredestijd. Tussen 1914 en 1918 stierven alleen al in de West-Europese oorlogsgebieden meer dan acht miljoen paarden en muildieren ten gevolge van verwondingen, uitputting of besmettelijke ziekten. De grootste verliezen traden op bij de artilleriepaarden. In heel de oorlog gingen 484.000 Britse paarden verloren of one horse for every two men. Moeilijk behandelbare infectieuze ziekten als schurft veroorzaakten aanzienlijke verliezen. In de Tweede Wereldoorlog werden paarden bijna uitsluitend voor logistieke doelen gebruikt. Zoals in de Eerste Wereldoorlog moesten de paarden grote afstanden afleggen en was er te weinig voeder en slechte verzorging. De sterfte was dan ook groot. Het Duitse leger beschikte over 2.500.000 tot 2.750.000 paarden. De verliezen worden geschat op 1.500.000 tot 1.750.000. Dit was minder dan in de Eerste Wereldoorlog, wellicht door een betere veterinaire verzorging. Initiatieven zoals The blue Cross ter bescherming van dieren ontstonden tijdens de oorlogen, net als de tegenhanger voor mensen, het Rode Kruis. Slechts sporadisch werd een gedenkteken opgericht voor de vele paarden en muildieren die op de slagvelden aan hun eind kwamen.
Получение униполярных импульсов в дальней зоне источника
Authors: Архипов М.В. , Архипов Р.М. , Розанов Н.Н.
Published: June 2021

Under the pulses with non-harmonic waveform, propagate in free space, the time dependence of the field strength changes. In the far field or when the radiation is focused on the focal point, the field strength becomes proportional to the time derivative of the source field. If the field in any near zone is unipolar, then differentiation will lead to unipolarity lost. Based on these considerations, it is usually concluded that the practical use of radiation from unipolar sources is extremely limited. Since any propagation and attempts to focusing will lead to the loss of radiation unipolarity. However, this limitation does not effect situations when the field is depended on time in a near zone having a special form. In this note, conditions are given when it is possible to obtain unipolar pulses in the far field zone.
Влияние геометрии и модового состава излучения на рассеивающие свойства кварц-полимерного оптического волокна со светоотражающей оболочкой Tefzel
Authors: Маковецкий А.А.
Published: June 2021

Для кварц-полимерного оптического волокна с диаметром световедущей сердцевины 400 μm и с рассеивающей светоотражающей оболочкой из термопластичного сополимера тетрафторэтилена с этиленом марки Tefzel проведен численный расчет гибридных мод. Для выбранных мод были рассчитаны радиальный профиль и определяющая рассеяние величина chi --- относительная доля энергии моды, распространяющейся по светоотражающей оболочке. Функция chi(m,s) монотонно возрастает с увеличением азимутального числа m и уменьшается с увеличением радиального числа s. Наибольшее значение chi достигается у моды с максимально возможным для данного оптического волокна значением m=953, при котором существует только одна мода с s=1. При уменьшении диаметра световедущей сердцевины рассеивание возрастает. Полученные расчетно-теоретические результаты были качественно подтверждены экспериментами по измерению рассеяния в кварц-полимерных оптических волокнах со светоотражающей оболочкой Tefzel с диаметрами световедущей сердцевины 400 и 200 μm. Ключевые слова: многомодовое оптическое волокно, рассеивающая светоотражающая оболочка, характеристическое уравнение, расчет радиальных профилей мод, доля излучения моды, распространяющегося по оболочке.
A Full-Scale Agent-Based Model to Hypothetically Explore the Impact of Lockdown, Social Distancing, and Vaccination During the COVID-19 Pandemic in Lombardy, Italy: Model Development
Authors: Giacopelli Giuseppe
Published: June 2021

Background

The COVID-19 outbreak, an event of global concern, has provided scientists the opportunity to use mathematical modeling to run simulations and test theories about the pandemic.

Objective

The aim of this study was to propose a full-scale individual-based model of the COVID-19 outbreak in Lombardy, Italy, to test various scenarios pertaining to the pandemic and achieve novel performance metrics.

Methods

The model was designed to simulate all 10 million inhabitants of Lombardy person by person via a simple agent-based approach using a commercial computer. In order to obtain performance data, a collision detection model was developed to enable cluster nodes in small cells that can be processed fully in parallel. Within this collision detection model, an epidemic model based mostly on experimental findings about COVID-19 was developed.

Results

The model was used to explain the behavior of the COVID-19 outbreak in Lombardy. Different parameters were used to simulate various scenarios relating to social distancing and lockdown. According to the model, these simple actions were enough to control the virus. The model also explained the decline in cases in the spring and simulated a hypothetical vaccination scenario, confirming, for example, the herd immunity threshold computed in previous works.

Conclusions

The model made it possible to test the impact of people’s daily actions (eg, maintaining social distance) on the epidemic and to investigate interactions among agents within a social network. It also provided insight on the impact of a hypothetical vaccine.
Measuring the Impact of COVID-19 on Siyan Mental Health Patients Using the Epidemic-Pandemic Impacts Inventory: Survey Study
Authors: Shah Anish , Darling Michele , Arstein-Kerslake Olivia , Morgan Tiffany , Vance Tovrea Aubreen , Young James , Laines Helen
Published: June 2021

Background

Recent research has shown that the impacts of the COVID-19 pandemic and social isolation on people’s mental health are quite extensive, but there are limited studies on the effects of the pandemic on patients with mental health disorders.

Objective

The objective of this study was to assess the negative impacts of the COVID-19 pandemic on individuals who have previously sought treatment for a mental health disorder.

Methods

This study uses the newly developed Epidemic-Pandemic Impacts Inventory (EPII) survey. This tool was designed to assess tangible impacts of epidemics and pandemics across personal and social life domains. From November 9, 2020, to February 18, 2021, a total of 245 adults recruited from a mental health clinic completed the consent form and responded to the survey link from the Siyan Clinical Corporation and Siyan Clinical Research practices located in Santa Rosa, California, USA.

Results

We found that the least affected age group included individuals aged 75 years or older. This was followed closely by the 65- to 75-year-old age group. People with children under the age of 18 years also reported both more negative indicators associated with the pandemic and more positive indicators compared to those without children at home. Gender queer, nonconforming, and transgender individuals may also be at higher risk for more negative impacts associated with the pandemic. When respondents were assessed with regard to their mental health diagnosis, no differences were noted. Substance use also increased during the pandemic.

Conclusions

In conclusion, the data collected here may serve as foundational research in the prevention, care, and treatment of mental health disorders during pandemics such as COVID-19. Populations such as those with previously diagnosed mental health disorders are particularly at risk for negative effects of pandemic-related stressors such as social isolation, especially if they have children in the household, are part of a younger age group, or have substance use disorder. Gender may also be a factor. Further, the EPII survey may prove to be a useful tool in understanding these effects. Overall, these data may be a critical step toward understanding the effects of the COVID-19 pandemic on populations with a mental health diagnosis, which may aid mental health practitioners in understanding the consequences of pandemics on their patients’ overall well-being.

Trial Registration

ClinicalTrials.gov NCT04568135; https://clinicaltrials.gov/ct2/show/NCT04568135
Impact of activity trackers on secondary prevention in patients with coronary artery disease: a systematic review and meta-analysis (Preprint)
Authors: Kaihara Toshiki , Intan-Goey Valent , Scherrenberg Martijn , Falter Maarten , Frederix Ines , Dendale Paul
Published: June 2021

BACKGROUND

Ischemic heart disease (IHD) is related to high rates of morbidity and mortality among cardiovascular diseases (CVD). Activity trackers have been used in cardiac rehabilitation (CR) in the last years. However, their effectiveness to influence outcomes after IHD is debated.

OBJECTIVE

This review summarizes the latest data of impact of activity trackers on CVD risk and outcomes.

METHODS

Articles from 1986 to 2020 in English were searched by electronic databases (PubMed, Cochrane Library, Embase). Inclusion criteria were: randomized controlled trials of IHD secondary prevention using an activity tracker which include at least peak oxygen consumption (VO2), major adverse cardiovascular events (MACE), quality of life (QoL), LDL-cholesterol (LDL-C) as outcomes. Meta-analysis and qualitative analysis were performed.

RESULTS

After removing duplicates, 604 articles were included and the screening identified a total of 11 articles. Compared to control groups, intervention groups with activity trackers significantly increased peak VO2 (mean difference 1.54; 95% CI [0.50–2.57]; P=.004) and decreased MACE (risk ratio 0.51; 95% CI [0.31–0.86]; P=.01). Heterogeneity was low (I2=0%) for MACE and high (I2=51%) for peak VO2. Intervention with an activity tracker also has positive impact on QoL in qualitative analyses. There was no between-group difference in LDL-C.

CONCLUSIONS

CR using activity trackers has a positive and multi-faceted effect on peak VO2, MACE, and QoL in patients with IHD.
High national acceptance for COVID-19 contact tracing technologies in Taiwan (Preprint)
Authors: Garrett Paul M. , Wang Yuwen , White Joshua P. , Kashima Yoshihisa , Dennis Simon , Yang Cheng-Ta
Published: June 2021

BACKGROUND

Governments worldwide have introduced COVID-19 tracing technologies. Taiwan, a world leader in controlling the virus’ spread, has introduced the Taiwan ‘Social Distancing App’ to facilitate COVID-19 contact tracing. However, for these technologies to be effective, they must be accepted and used by the public.

OBJECTIVE

Our study aimed to determine public acceptance for three hypothetical tracing technologies: a centralized Government App, a decentralized Bluetooth App (e.g., Taiwan’s Social Distancing App), and a Telecommunication tracing technology; and model what factors contributed to their acceptance.

METHODS

Four nationally representative surveys were conducted in April 2020 sampling 6,000 Taiwanese residents. Perceptions and impacts of COVID-19, government effectiveness, worldviews, and attitudes towards and acceptance of one-of-three hypothetical tracing technologies were assessed.

RESULTS

Technology acceptance was high across all hypothetical technologies (67% - 73%) and improved with additional privacy measures (82% - 88%). Bayesian modelling (using 95% highest density credible intervals) showed data sensitivity and perceived poor COVID-19 policy compliance inhibited technology acceptance. By contrast, technology benefits (e.g., returning to activities, reducing virus spread, lowering the likelihood of infection), higher education, and perceived technology privacy, security, and trust, were all contributing factors to overall acceptance. Bayesian ordinal probit models revealed higher COVID-19 concern for other people than for one’s self.

CONCLUSIONS

Taiwan is currently using a range of technologies to minimize the spread of COVID-19 as the country returns to normal economic and social activities. We observed high acceptance for COVID-19 tracing technologies among the Taiwanese public, a promising and necessary finding for the successful introduction of Taiwan’s new ‘Social Distancing App’. Policy makers may capitalize on this acceptance by focusing attention towards the App’s benefits, privacy and security measures, making the App’s privacy measures transparent to the public, and emphasizing App uptake and compliance among the public.

CLINICALTRIAL

Not applicable.
The role of skin microbiome in the development of atopic dermatitis in children
Authors: Volosovets O.P. , Kryvopustov S.P. , Mozyrskaya O.V.
Published: June 2021

Atopic dermatitis is a chronic itchy skin disease with a characteristic localization and morphology of skin lesions associated with an impairment of the skin barrier function and an atopic background. Malassezia species have been associated with a number of skin conditions, including atopic dermatitis. It is the most common fungal genus of healthy skin, but this yeast also may have a pathogenic potential under certain conditions. A close relationship has been shown between skin and Malassezia allergens that bind IgE in atopic dermatitis. They interact with almost all cellular constituents of the normal epidermis, including keratinocytes, Langerhans cells, melanocytes, and the host’s immune system. It is known that Malassezia yeasts are of great importance in the development of skin sensitization in atopic dermatitis. Malassezia colonize human skin after birth and therefore, as a commensal, should be normally recognized by the human immune system. The presence of polymorphisms in the PRR genes can cause the development of atopic dermatitis in children. Despite the current knowledge about the association of Malassezia species with the development of atopic dermatitis, the mechanisms underlying the change in their state from commensal to pathogenic still require further elucidation. In addition, there is a need for standardization of diagnostic methods and testing for antifungal susceptibility.
Glycemic control and awareness of foot care indiabetic foot syndrome
Authors: Atayoglu Ayten Guner , Atayoglu Ali Timucin , Ozgur Rahime , Khan Hammad
Published: June 2021

Background. The chronic complications of diabetes mellitus (DM) result from a wide variety of effects of disease. The correlation between blood sugar level and chronic complications has been demonstrated in various studies. Patient education, risk factor management, and other preventative measures are critical elements in reducing the incidence of diabetes complications such as Diabetic Foot Syndrome (DFS). We purposed to evaluate knowledge and attitudes towards foot care amongst patients with diabetes mellitus; in addition, we investigated the correlation between glycemic control and DFS. Materials and methods. This was a descriptive cross-sectional evaluation of patients who were diagnosed with diabetes mellitus seeking outpatient medical care with data being collected through patient surveys, clinical evaluation, specialty consultation, and biochemical analysis of glycated haemoglobin (HbA1c) serum levels. The population of the study was composed of 90 patients diagnosed with DM. Results. A total of 90 patients, 42 (46.7%) females and 48 (53.3%) males were included in the study. The rate of participants who reported completing daily self-evaluations for wounds, cracks, and discoloration on the feet was significantly higher (68.9%) than those who reported not evaluating on a daily basis (31.1%). Almost half of the participants were diagnosed with DFS (n=43; 47.7%) with the HbA1c levels of patients with DFS being significantly higher compared to the HbA1c levels of patients without DFS (p < 0.05). Conclusions. As a high incidence of DFS was found with a positive and statistically significant correlation between the HbA1c level and DFS presence, our study highlights the importance of close monitoring, education, and treatment given the risk of serious complications of DM such as DFS in setting of poorly controlled DM.
Antithyroid autoantibodies in extrathyroid autoimmune diseases
Authors: Sorokman T.V. , Gingulyak M.G. , Makarova O.V.
Published: June 2021

This review summarizes data on the incidence of autoimmune diseases and examines the prevalence of antithyroid antibodies in extrathyroid autoimmune diseases. In the world, about 5–7% of the population suffers from one or another type of autoimmune diseases. Among the six most common autoimmune diseases, thyroid and associated diseases predominate. The high prevalence of autoimmune thyroid diseases raises questions about the potential role of antithyroid antibodies in the course of extrathyroid autoimmune diseases. It is believed that autoimmune diseases are the result of interactions between triggers, autoantigens, genetic predisposition, impaired tolerance of autoantigens and mechanisms of apoptosis. Among the currently known antithyroid autoantibodies, antibodies to thyroglobulin (TgAb), thyroid peroxidase (TPO), as well as bispecific autoantibodies to thyroglobulin and thyroid peroxidase are of particular importance. Categories of functionally significant autoantibodies that mimic hormone function and provoke the development of autoimmune pathology as a result of binding to the receptor and subsequent stimulation of thyrocytes include antibodies to thyroid-stimulating hormone receptor (rTSH-Ab). Circulating antibodies against thyroid antigens are not limited to autoimmune diseases of the thyroid gland, but are also found in other autoimmune diseases, most often in rheumatoid arthritis, type 1 diabetes mellitus and celiac disease. The association with other immune pathologies further confirms that TPO antibodies were also detected in 15% of patients with asthma, in 10–29% of those with idiopathic purpura and vitiligo. The prevalence of TPO antibodies is slightly higher than TgAb, and rTSH-Ab are rarely registered in non-thyroid immunological diseases.
Diabetes mellitus, platelet function and acetylsalicylic acid
Authors: Gendeleka G.F. , Gendeleka A.N.
Published: June 2021

Diabetes mellitus is an independent risk factor for cardiovascular disease (CVD). Accelerated development of atherosclerosis in patients with diabetes is a consequence of endothelial dysfunction, low-grade inflammation, oxidative stress, dyslipidemia, and platelet dysfunction. The results of studies have shown that among diabetic patients there is a high percentage of no effect when using both acetylsalicylic acid (ASA) and clopidogrel. It is necessary to distinguish between patients with a weak response and people with no effect— resistant to aspirin. The frequency of the so-called aspirin resistance, according to modern research, is different and depends on the methods used to study platelet function. In diabetic patients, it ranges from 5 to 45% when taking ASA and from 4 to 30% when taking clopidogrel. Recent studies show an even higher proportion of such individuals among people with diabetes. The appropriateness of lifelong ASA for secondary prevention in people diagnosed with CVD is indisputable (level of evidence A). At the same time, approaches to primary prevention vary in different countries. It is emphasized that the primary prevention with ASA in modern conditions maintains a favorable balance of benefits/risks. The new guidelines state that the calculated 10-year risk of cardiovascular events should not be considered when deciding whether to prescribe ASA to patients without CVD. Instead, all risk factors present in each patient should be considered, including burdensome family history, inability to achieve lipid and glycemic levels, and coronary calcification. The conclusion that ASA has evidence-based efficacy in secondary prophylaxis in patients with CVD has been confirmed. Regarding the primary prevention of cardiovascular events, including healthy individuals, the appropriateness, duration of administration, and choice of ASA should be determined taking into account the 10-year development of serious events, the presence of comorbidities, and the risk of bleeding.
R-enantiomer of α-lipoic acid. Opportunities and prospects for clinical use
Authors: Kravchun N.A. , Dunaieva I.P. , Kravchun P.P.
Published: June 2021

The paper presents an analysis of current literature data on the use of the R-enantiomer of α-lipoic acid as an antihypertensive treatment in patients with hypertension and metabolic syndrome. An analysis of the literature was carried out on its use as an antiinflammatory agent in inflammatory diseases. Currently, a very important aspect of researches is the possibility of using R-α-lipoic acid as a micronutrient and therapeutic agent for the treatment of diabetic polyneuropathy and neurodegenerative diseases, especially Alzheimer’s disease, carbohydrate metabolism disorders and metabolic syndrome. Lipoic acid has now become an important ingredient in multivitamin formulas, anti-aging supplements. R-α-lipoic acid is a metabolic antioxidant, its molecule contains a dithiolane ring in oxidized form, this ring has the ability to cleave with formation of dihydrolipoic acid. And since α-lipoic acid, a physiological form of thioctic acid, is a strong antioxidant that relieves the symptoms of diabetic neuropathy, the literature review analyzed data from various authors on the antioxidant effects of the R-enantiomer of α-lipoic acid and found that it had strong antioxidant effects, and its dose of 300 mg is bioequivalent to 600mg of racemic α-lipoic acid. As presented in a sufficient number of analyzed sources, the biological role of lipoic acid is quite diverse. It is important to determine the exact causal relationship between lipoic acid and its immediate cellular targets. Lipoic acid can have a number of important and diverse physiological effects on the stimulation of neurohormonal function and, thus, indirectly affect multiple cellular signaling pathways in peripheral tissues.
A multidisciplinary approach to the management of inflammatory bowel diseases: surgical complications — how not to miss by therapist
Authors: Nechypurenko T.B.
Published: June 2021

The article deals with a condition that is complex for diagnostic search — inflammatory bowel diseases (IBD). Frequent complication of IBD by acute surgical manifestations, the possibility of the onset of diseases from surgical lesions determines the practical need for physicians to be aware of the management of IBD with complicated pathology. The article presents a clinical case — the complication of ulcerative colitis by multiple colonic perforations, which were not detected in time. The diagnostic search allowed us to find out intraoperatively the causes of acute surgical manifestations, to diagnose complications, and the prescribed adequate postoperative treatment stabilized the patient’s state.
Zemstvo doctor Vasyl Leontovych— the father of the dynasty of scientists
Authors: Chaban M.P. , Shevtsova Z.I. , Gaponov V.V.
Published: June 2021

The article describes the life and professional activity of zemstvo doctor, a descendant of the Zaporozhian Cossacks Vasyl Fedorovych Leontovych (1842–1888). The young man was a graduate of the Yekaterynoslav Classical Gymnasium in 1862. The doctor managed to start a dynasty of outstanding domestic scientists. His son Oleksandr became a physiologist, academician. His grandson Mykhailo is a physicist and academician; granddaughter Tatiana and great-granddaughter Natalia are doctors of medical sciences. The Leontovych family is an example of the medical dynasty of Cossacks.
The Effect of Human Resources Management Skills on Accounting Information Quality in Kurdistan Public Sector
Authors: Qader Khowanas Saeed , Ismeal Bayar Ali , Aziz Hassan Mahmood , Hamza Pshdar Abdalla , Sorguli Sarhang , Sabir Bawan Yassin , Anwar Govand , Gardi Bayar
Published: June 2021

The article’s purpose is to measure the impact of human resources management skills on accounting information quality in kurdistan public sector. To enable the study to measure human resource management skills at public sectors in Kurdistan region of Iraq, the researchers used five human resources management skills elements, first is communication skill, second is flexibility skill, third is negotiation skill, fourth is ethical action skill, and fifth is compassion skill. To assess the current study, the researchers used a quantitative research method in the form of a survey. The questionnaire was delivered at random to 84 administrative employees from several government departments in the Kurdistan region. The researchers, on the other hand, were able to collect 78 completed questionnaires. The results showed that as for the impact of communication skill on accounting information system was found the value of Beta is .632 with significant level .000 this indicated that first research hypothesis is supported which is Communication skill as human resource management skills has a positive and significant influence on accounting information system. As for the impact of Flexibility skill on accounting information system was found the value of Beta is .611 with significant level .000 this indicated that second research hypothesis is supported which is Flexibility skill as human resource management skills has a positive and significant influence on accounting information system. As for the impact of Negotiation skill on accounting information system was found the value of Beta is .642 with significant level .000 this indicated that third research hypothesis is supported which is Negotiation skill as human resource management skills has a positive and significant influence on accounting information system. As for the impact of Ethical actions skill on accounting information system was found the value of Beta is .649 with significant level .000 this indicated that fourth research hypothesis is supported which is Ethical actions skill as human resource management skills has a positive and significant influence on accounting information system, and lastly, as for the impact of Compassion skill on accounting information system was found the value of Beta is .661 with significant level .000 this indicated that fifth research hypothesis is supported which is Compassion skill as human resource management skills has a positive and significant influence on accounting information system
Evaluation of Boccia Sports Achievement Coaching Program using Cipp Model at the Boccia NPC Indonesia National Training Center
Authors: Kasih Andrian Martgatha , Hidayatullah M. Furqon , Doewes Muchsin
Published: June 2021

The present research focus on determining the achievement of the Boccia sports achievement coaching program using the CIPP evaluation model at the Boccia NPC Indonesia National Training Center in 2019/2020. The type of research used is program evaluation research. The evaluation model used is the evaluation model context, input, process, product (CIPP). Sources of data obtained from three objects namely paper, place and person. Data collection techniques in this research used observation, questionnaires, interviews, and observations. The research instruments are observation guidelines, interviews and questionnaires. The data analysis technique in this research is descriptive data analysis, namely qualitative descriptive data analysis and quantitative descriptive data analysis. The result of the percentage value of context evaluation is 87.5% in good category, the result of the percentage value of input evaluation is 86.5% in good category, the result of the percentage value of process evaluation is 88.67% in good category, and the result of the percentage value of product evaluation is 89, 8% with good category. Based on the results of the evaluation of the questionnaire assessment and has been analyzed using quantitative descriptive data analysis techniques, it can be concluded that the evaluation of the Boccia sports achievement coaching program is categorized as good.
Expresiones arquitectónicas del siglo XX. Racionalistas y funcionalistas
Authors: Camacho-Cardona Mario
Published: June 2021

The essay sets off from the contextualization of two notions and influences: the American by Frank Lloyd Wright and the European from Le Corbusier. Such contextualization grew within the Avant-garde known as Functionalism and Rationalism in order to deepen into the architectural percepts of the 20th Century.
It also addresses the utilitarian function of human activities that have an impact on the purity of the form applied to architectural works in Mexico. This is characterized by the phenomenological deepening in space from the artistic and aesthetic perspective that gave meaning to a developed theoretical position at FES Acatlán between 1970 and 1980.
Voz a tu mirada
Authors: De la Calleja Miguel Ángel
Published: June 2021

To pupils that wander constantly around diverse sites, not always are textures of architecture shown in the aimed clarity. The superficial contact -gaze and touch- only allows, in many occasions, a passing glance. However, we inhabit places and transform them with the assiduity of our body (physical, sensual and of thought) which day by day installs itself and shapes a home. Little by little, the fugitive and inaccurate aspects of our public space acquire, unnoticed, the importance of linking us to them. Thus, introspection occurs and we randomly find a profound knowledge of ourselves and the place we have resided in.
By weaving the parts of a whole, the photograph (although several) captures the coincidences of the spaces where –in a bricolage – the quotidian regularity of passing by, and sometimes settling down in, each of those places reaches symmetry, even considering the consented permutations. This gaze converts the architectural rhythm of the Facultad de Estudios Superiores Acatlán into a contemporary Trompe-l'œil where, as stated by Nicolas Poussin, all «of this its place will find».
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Leopoldo Zea y su discurso filosófico contra la marginalidad (1948-1953)
Authors: Reyes-Ruiz Emilio
Published: June 2021

Between 1949 and 1953, Leopoldo Zea published four writings in which he explained how the Mexican Revolution brought about the possibility for Mexicans to escape from situations of marginality and servitude to which they had been condemned due to the cultural impositions of Western imperialism. The writings have the distinction of dealing with the Mexican Revolution and the philosophical thought in Mexico, while linking them to a more general context: the European crisis and the critical review of the philosophical tradition during the first half of the 20th century. By means of a methodology of interpretation of the texts, this text addresses how Zea explains those situations of marginality, why the Revolution was the opportunity of breaking with them, as well as the inherent philosophical value in those writings. The conclusion emphasizes the philosophy concept that the author offers in light of the marginalization problems of the 20th century.
La urdimbre escolar. Una propuesta de investigación educativa
Authors: Martínez-Vázquez Fernando
Published: June 2021

The present text reviews the books corresponding to the project The school fabric: words and glances. The content of each one and their contributions to the field of educational research at the high school education level are described, particularly highlighted are researches that had been useful to understand the social and cultural phenomena related to students and teachers; additionally, little worked lines of research are also explored.
Minuciosos panoramas
Authors: De la Calleja Miguel Ángel , Véliz Cantú Mayela Eunice
Published: June 2021

The breadth of the minuscule becomes a dim visual oxymoron; but, while subtle, it does not lose its intensity in the display of different perspectives or in the attribution of sensations in ways that do not correspond directly. Thus, the textures digitize the skin, and the aromas turn the sense of smell in these images.
To look inside is to look outside at the complexity of the universe. In the encounter of the fractalities, in the differences, the equalities converge. By accepting it, we assume the gift that we have as humans: especially when the panoramas are achieved through minutiae.
 
MVC-MACL

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Intercambios Oceánicos–México. Trazando redes de información global en repositorios de periódicos históricos, 1840-1914
Authors: Castellanos-Rueda Rocío
Published: June 2021

Oceanic Exchanges was configured as an international project composed of researchers from six countries, including Mexico. The national team was coordinated by the Hemeroteca Nacional de México to work on digital tools that would allow -as the name of the project indicates- to trace global information networks in historical newspapers repositories between 1840 and 1914. The text analyzes the news searches made in various case studies in order to present the different methodologies used and develop information flows, news circulation and origin of informative texts, as well as the use and reuse of news. In general, is the aim to offer an innovative approach to work out digital repositories from various countries.
Raza, género y poder colonial en la Nueva España (Siglos XVI-XVII)
Authors: Apodaca-Valdez Manuel
Published: June 2021

With the support of gender, race, and ethnicity theories framed in the history of Afro-Latin American culture, this article analyzes literary narratives and historical documents to explain that the antecedent of current racism is found in the discourse and structure of the colonial system, and it's enslaving, religious, and corporative ideology, which derived in hierarchical segregation of castes and an increase of mestizaje. Although the concept of race as we know it today did not exist in their consciousness, a policy of racial domination is perceived in the classist gaze of the Creoles of 'the literate city', which is discussed here through the analysis of the relation as a literary and historical instrument, particularly, Alboroto y Motín de México, written by Carlos de Sigüenza y Góngora. In New Spain colonial context of the 16th and 17th centuries, racism, sexism, and gender violence established barriers of the body in relation to the Other, which generated the segregation of African descendants, indigenous, and mestizo populations, as can be seen in the colonial power's writs and juridical codes. Much of that historical and epistemic violence is projected in the society and culture of Mexico and Latin America to this day.
La prostitución como principal actividad económica para el establecimiento de la ciudad de Mexicali a inicios del siglo XX
Authors: Roldán-Mendoza Iván Alexis
Published: June 2021

In the book Un pequeño Montecarlo en el desierto Mexicali 1901–1913, Lorenia Ruiz Muñoz established that prostitution has been developed as a buoyant economic activity for Mexicali's development, in her research a variety of historical records from the early 20th century are analyzed.
Las redes de la razón
Authors: Troconis Elik G.
Published: June 2021

Writing is a process of self-conviction. Through it, the author’s reason sets before their soul the principles by which it wishes to be guided.