bluuebunny/crossref_metadata_2025 huggingface dataset:
Conflict Management and Strategy Management at the State Borders of Indonesia
Authors: Toruan Tahan Samuel Lumban , Riyadi Bambang Slamet , Gusti Djasa Pinara
Published: July 2023

This research aims to understand conflict management and strategy at state borders and its implications that are very due at the ontological level and sociological level. The problem is very interesting to be analyzed by conducting a qualitative case study in Indonesia. The data were collected through observation and documentation. The data were analyzed using interactive steps of data reduction, data display, and data verification, supported by triangulation. The results indicate that managing conflict and strategy at state borders and its implementation are needed for providing information to stakeholders to update regulations and sanctions. This result provides inputs for making better regulation and policy for state agencies as public officials and practitioners.
Comparative Analysis of the Use of Wine Pouch Based on Sustainability and Consumer Resilience Aspects
Authors: Eisinger Balassa Boglárka , Koteczki Réka , Lukács Bence , Csiba-Herczeg Ágnes
Published: July 2023

Wine packaging, which is one of the largest CO2 emitting areas of the wine market, is undergoing significant changes. Alternative packaging has appeared on the market and is expected to gain ground in the near future, replacing the classic glass bottles. The key research question is: how do different types of packaging influence wine purchasing decisions and what cognitive biases can be identified in the decision-making process? The aim of this paper is to investigate two alternative packaging formats, the pouch and the bag-in-box, from two perspectives: sustainability and consumer behavior. To carry out the sustainability analysis, we used data provided by a Hungarian winery, with the help of which we determined the production and transport emissions of pouch and bag-in-box. In addition to presenting sustainability indicators, we aimed to assess the level of resilience of these consumers in the wine market, using an experiment. The results suggest that Hungarian participants are resilient to use new alternative packaging types, but prefer bagin-box packaging to pouches, which can be considered the novelty of the study.
Migracija prema slušanju radija na digitalnim platformama
Authors: Mučalo Marina , Šulentić Anita
Published: July 2023

Dominantan oblik distribucije radijskog programa u Republici Hrvatskoj i dalje je zemaljska‎ distribucija analognog signala. Međutim, digitalno doba nudi alternativu, poput internetske distribucije ‎i digitalnog radija (DAB+). Prva faza konvergencije hrvatske radiodifuzije dovršena je već samom‎ uspostavom radijskih mrežnih stranica koje zahvaljujući streamingu mogu distribuirati sadržaj svagdje ‎gdje postoji pokrivenost internetom. Prva koncesija za komercijalni DAB+ radio u Republici Hrvatskoj‎ dodijeljena je u veljači 2022., a emitiranje je počelo u kolovozu iste godine. Ključan preduvjet dohvata‎ sadržaja tako distribuiranih radijskih programa jesu digitalni uređaji, poput računala i pametnih telefona,‎ te kućni i automobilski digitalni prijamnici. Rad donosi nalaze istraživanja o migraciji radijskih‎ slušatelja s tradicionalnih uređaja (analognih prijamnika) prema slušanju na digitalnim platformama‎ u Republici Hrvatskoj. Naime, iako nema najava o eventualnom isključenju analogne mreže, može se‎ očekivati da će digitalne opcije za dohvat radijskih programa biti sve više korištene. Prema rezultatima ‎istraživanja, prvog takve vrste u nas, migracija je zasad mala (oko 13 %) i spora, ali kontinuirana. Konvergencija‎ radijskog medija odvija se i onda kada za nju ne postoje strateški određeni preduvjeti jer sazrijevanje ‎generacija koje su odrastale u „oba svijeta” sustavno smanjuje nekadašnji „generacijski jaz” u digitalnim‎ znanjima i kompetencijama, što olakšava tranziciju od analognih prema digitalnim uređajima za‎ slušanje radijskih programa.‎
The Future of Leishmaniasis Treatment: Protein Targets and Beyond
Authors: Padilla Carlos A. , Álvarez María J. , Campo Emmanuel , Severiche José G. , Combariza Aldo F.
Published: July 2023

This review summarizes up-to-date research on Leishmania protein structures, extracted primarily from the Protein Data Bank (PDB), that are involved in metabolic pathways of the parasite causing \textit{Leishmania}. Additionally, we examine current advancements in identifying and developing bioactive chemical agents to treat this largely neglected tropical disease. We examined experimental data from \textit{in vitro}, \textit{in vivo}, or \textit{in silico} sources, classifying the information into four categories: a) vector taxonomy and geographical distribution; b) parasite taxonomy and geographical distribution; c) enzymatic functions of proteins involved in parasite/host interactions across developmental stages (e.g. oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, and cytokines); and d) standard and experimental treatments using bioactive chemical compounds. Our goal is to provide a reference framework for research focused on elucidating interaction mechanisms and ligand-protein activation/inactivation processes related specifically to \textit{Leishmania} infections. We therefore highlight enzymes known to participate in biochemical pathways triggered during Leishmania infection episodes. This review summarizes current knowledge to inform and guide future discovery efforts targeting proteins and pathways for improved \textit{Leishmania} disease management.
Quantifying the Nonadiabaticity Strength Constant in Recently Discovered Highly-Compressed Superconductors
Authors: Talantsev Evgeny F.
Published: July 2023

Superconductivity in highly-pressurized hydrides became primary direction for the exploration of fundamental upper limit for the superconducting transition temperature, Tc, after Drozdov et al (Nature 2015, 525, 73) discovered superconducting state with Tc=203 K in highly-compressed sulphur hydride. To date several dozens of high-temperature superconducting polyhydrides have been discovered. In addition, recently, it was reported that highly-compressed titanium and scandium exhibit record-high (up to 36 K), which is by manifold exceeded of niobium, which is the record high- ambient pressure metallic superconductor. Here we analysed experimental data on for recently discovered high-pressure superconductors (which exhibit high transition temperatures within their classes): elemental titanium (Zhang et al, Nature Communications 2022; Liu et al, Phys. Rev. B 2022), TaH3 (He et al, Chinese Phys. Lett. 2023), LaBeH8 (Song et al, Phys. Rev. Lett. 2023), and black (Li et al, Proc. Natl. Acad. Sci. 2018) and violet (Wu et al, arXiv 2023) phosphorous, to reveal the nonadiabaticity strength constant, TθTF (where Tθ is the Debye temperature, and TF the Fermi temperature) in these superconductors. The analysis showed that δ-phase of titanium and black phosphorous exhibit the Tθ/TF which are nearly identical to ones associated in A15 superconductors, while studied hydrides and violet phosphorous exhibit the constants in the same ballpark with H3S and LaH10.
Myocardial Infarction, Deep Venous Thrombosis, and Pulmonary Embolism in SARs-CoV-2 Hospitalizations; Insights from the National Inpatient Sample 2020
Authors: Evbayekha Endurance , Okorare Ovie , Alugba Gabriel , Willie Anthony , Omosumwen Ede , Emeasoba Chinemerem Martlin , Salaudeen Bolanle Hawau , Onyekwere Anita Ogochukwu , Agho Awanwosa Valentine , Okunromade Omolola , Busari Adeniyi Kayode , Akinsete Agatha Olawunmi , Emore Erhieyovbe , Sanusi Ibilola Akorede , Nnaemeka Agunwa , Odoma Victor Ameh , Ugonma Lovette , Okobi Emeka Kenneth , Okobi Okelue E.
Published: July 2023

Background: We studied the outcomes of SARS-CoV-2 (COVID) hospitalizations and their association with myocardial injury and thrombosis. Methods: Retrospective analysis of the National Inpatient Sample 2020 database. Results: We identified 335,799 hospitalizations with COVID. Of these, 1.6% (5,355) were diagnosed with non-ST-segment myocardial infarction (COVNSTEMI). The mean age of COVID hospitalizations was 71.7, with 60.50% being males. The population prevalence included 53.10% Whites, 17.80% Blacks, 19.20% Hispanics, and 4.10% Asians. The average length of stay (LOS) was 10 days, and 37.60% of patients died during their hospitalization. The average cost of hospitalization (TOTCHG) was $156,633. The COVSTEMI group comprised 1,364 cases, with a mean age of 67.4, in-hospital mortality of 47.4%, and the mean TOTCHG was $177,600. The DVTCOV group comprised 2,869 cases, while the PECOV group had 4,828 cases. Male predominance was observed in both groups, with mean ages of 66 years in the DVTCOV group and 64 years in the PECOV group. The DVTCOV group had a LOS of 16 days, with 24.71% mortality, while the PECOV group had a LOS of 11 days, with 19.20% mortality. The average TOTCHG in the DVTCOV group was $248,900, whereas it was $145,378 in the PECOV group. Conclusion: Our study revealed significant mortality rates across different groups, including 38% in COVNSTEMI, 47% in COVSTEMI, 25% in DVTCOV, and 19% in PECOV. These findings highlight the severity of COVID-related complications and the substantial financial burden of hospitalization.
Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma
Authors: Yoo Daeseon , Min Kyueng-Whan , Pyo Jung-Soo , Kim Nae Yu
Published: July 2023

This study aimed to evaluate the diagnostic and prognostic roles of GATA3 immunohistochemistry in urothelial carcinoma (UC) through a meta-analysis. We investigated GATA3 immunohistochemical expression rates and performed a subgroup analysis based on tumor site, study location, and histological subtypes. The overall survival rates of patients with GATA3-positive and negative UC were compared. The estimated GATA3 expression rate was 0.748 (95% confidence interval [CI]: 0.704–0.787). GATA3 expression rates in the urinary bladder and urinary tract were 0.775 (95% CI: 0.727–0.818) and 0.614 (95% CI: 0.426–0.774), respectively. The GATA expression rates of noninvasive and invasive UCs were 0.965 (95% CI: 0.938–0.980) and 0.644 (95% CI: 0.581–0.702), respectively. In invasive UCs, there was a significant difference in GATA3 expression between non-muscular invasion and muscular invasion subgroups (0.937, 95% CI: 0.883–0.967 vs. 0.753, 95% CI: 0.645–0.836). GATA3 expression was the highest in the microcytic subtype among the histologic subtypes (0.952, 95% CI: 0.724–0.993). There was a significant correlation between GATA3 expression and better prognosis (hazard ratio: 0.402, 95% CI: 0.311–0.521). Taken together, GATA3 expression significantly correlated with low-stage and better prognosis in UC. GATA3 expression is highly variable across histological subtypes and it is careful interpreting GATA3 expression.
Effects from ESG Scores on P&C Insurance Companies
Authors: Bressan Silvia
Published: July 2023

Insurers act as institutional investors and underwriters of risk, therefore improving their own environmental, social, and governance (ESG) performance is important for the transmission of ESG values to all other economic sectors. We analyze ESG scores of worldwide Property and Casualty (P&C) insurers during 2012-2022, and show that more sustainable insurers have high operating leverage, although their combined ratios and z-scores reveal that they are financially stable. Additional results for the US subsample illustrate that stocks issued by sustainable insurers deliver positive excess returns. Overall, these findings suggest that sustainable practices are associated with the ability of insurers to execute business and create value.
This is important for insurance managers, investors, and policy makers, as insurers play a prominent role in promoting economic growth and stability.
Microsatellite Dataset for Cultivar Discrimination in Spring Orchid (Cymbidium goeringii)
Authors: Nam Da Eun , Cha Min Ju , Kim Yae Dam , Awasthi Manisha , Do Yuno , Kong Sam-Geun , Chung Ki Wha
Published: July 2023

Cymbidium goeringii, locally known as the spring orchid in Korea, is one of the most important and popular horticultural species in the family Orchidaceae. C. goeringii cultivars were originated from plants with rare phenotypes in wild mountains where pine trees commonly grow. This study aimed to determine the cultivar-specific combined genotypes (CGs) of short sequence repeats (SSRs) by analyzing multiple samples per cultivar of C. goeringii. In this study, we collected more than 4,000 samples from 67 cultivars and determined the genotypes of 12 SSRs. Based on the most frequent combined genotypes (CG1s), the average observed allele number and combined matching probability were 11.8 per marker and 3.118×10-11, respectively. Frequencies of the CG1 in 50 cultivars (n ≥ 10) ranged from 40.9% to 100.0%, with an average of 70.1%. Assuming that individuals with the CG1 are genuine in the corresponding cultivars, approximately 30% of C. goeringii on the farms and markets may be not genuine. The dendrogram of the phylogenetic tree and principal coordinate analysis largely divided the cultivars into three groups according to their countries of origin; however, the genetic distances were not distant among the cultivars. In conclusion, this dataset of C. goeringii cultivar-specific SSR profiles could be used for ecogenetic studies and forensic authentication. This study suggests that genetic authentication should be introduced for the sale of expensive C. goeringii cultivars. We believe that this study will help establish a genetic method for the forensic authentication of C. goeringii cultivars.
Biomedical Applications of Microbial Mediated Gold and Silver Nanoparticles: Current Prospects
Authors: sharma Shaina , Bajaj Anjali , Rajta Priyanjali , Regassa Hailemeleak , Gudeta Kasahun
Published: July 2023

Nanoparticles (NPs) have uniform chemical composition, size, and morphology. Microorganisms are of great interest in Nanoparticle synthesis. The green production of nanomaterials occurs either intracellularly or extracellularly. Gold and silver nanoparticles are mostly synthesised by the enzymatic degradation of metal ions. The produced NPs are characterized by different instruments such as ultraviolet visible, dynamic light scattering, x-ray diffraction, scanning electron microscope, transmission electron microscope, etc. Our review discusses the various biomedical applications of gold and silver nanoparticles synthesized by microbes via intracellular and extracellular mechanisms.
Acinetobacter thutiue sp. nov. and Acinetobacter kontum sp. nov., Isolated from Motorbike Repairing Workshop Soil
Authors: Tuyet Nhan Le Thi , Kim Jaisoo
Published: July 2023

Two isolates of Acinetobacter were isolated from the soil samples of motorbike repairing workshop floors in Vietnam, where motorcycle/scooter repairs generate various types of hazardous waste, including mainly used waste oil and fluids. Two isolates were Gram-stain-negative, coccobacilli-shaped, aerobic, non-motile, non-hemolytic, oxidase-negative, and catalase-positive, designated strains VNH17T and VNK23T. Growth of strains was inhibited by NaCl concentrations above 3% and grew at an optimal temperature of 20-35°C. Phylogenetic analysis based on 16S rRNA gene sequences revealed that two isolated strains formed a lineage within the family Moraxellaceae and clustered as members of the genus Acinetobacter. The predominant respiratory quinones of VNH17T and VNK23T are ubiquinone 9 and ubiquinone 8, and the polar lipids are mainly composed of diphosphatidyl glycerol, phosphatidylglycerol, and phosphatidylethanolamine. The major cellular fatty acids are C18:1ω9c, C16:0 and summed feature 3 (C16:1ω7c and/or C16 : 1ω6c). The DNA G+C content of VNH17T and VNK23T was 42.07% and 41.75%, respectively. In addition, the average nucleotide identity and in silico DNA-DNA hybridization relatedness values between VNH17T and VNK23T as well as between they and phylogenetically related type strains were below the threshold values used for species delineation. Based on genomic, chemotaxonomic, phenotypic and phylogenomic analyses, the isolated strains represent novel species in the genus Acinetobacter, for which the names Acinetobacter thutiue sp. nov. (type strain VNH17T = KACC 23003 = CCTCC AB 2023063), Acinetobacter kontum sp. nov. (type strain VNK23T = KACC 23002 = CCTCC AB 2023064) are proposed.
BIM Manager Role in the Integration and Coordination of Multidisciplinary Projects
Authors: Sampaio Alcínia Zita , Azevedo Gonçalo , Gomes Augusto M
Published: July 2023

Building Information Modelling (BIM) methodology have been optimizing the construction activity in all sectors: multidisciplinary designs development; construction planning and monitoring; building management and maintenance. A BIM environment aggregates several disciplines and different skillsets and in order to control and improve the quality of a BIM project, a BIM manager is required. The BIM manager has the responsibility to coordinate all tasks involved in a building design and associated activities usually workout over the project documents. The professional can access to various discipline models, located in a shared board, and request for amendments if inconsistencies are detected. The present study issue is illustrated with three building cases were distinct specific projects, disciplines and tasks were elaborated: collaboration between disciplines (architecture, structures and construction); structural analyses and reinforcement details; quantity take-off of materials and cost estimation; construction scheduling and simulation. Although there are limitations in the implementation of BIM methodology in all sectors and stages, within the construction industry, BIM have been bringing an important improvement in the quality of a building design, reflected in the quality of the final product. BIM methodology is a current demand in the construction industry supported on advanced technology and in an adequate management of projects, were the BIM manager has an important role.
The Vernalization Procedure Influences Growth and Metabolism of Tuberous Roots of Ranunculus asiaticus L.
Authors: Fusco Giovanna Marta , Carillo Petronia , Nicastro Rosalinda , Pagliaro Letizia , Modarelli Giuseppe Carlo , De Pascale Stefania , Paradiso Roberta
Published: July 2023

Ranunculus asiaticus L. is an ornamental geophyte, mainly propagated by rehydrated tuberous roots. Vernalization before planting is a common practice to overcome the natural dormancy of tuberous roots, however little is known about the mechanisms underlying the plant response to low temperature. We investigated the influence of two hybrids, MBO and MDR, and three preparation procedures of tuberous roots, only rehydration (control, C), and rehydration plus vernalization at 3.5 °C for 2 weeks (V2) and for 4 weeks (V4), on plant growth, leaf photosynthesis, flowering and metabolism in plants grown in pot in unheated greenhouse. We reported the responses observed in the aerial part previously in this journal (Fusco et al., 2023). In this paper, we show changes in carbohydrate, amino acids, polyphenols and protein levels throughout the growing cycle, in the different plant stages: pre-planting, vegetative phase and flowering.
Acute Kidney Injury, Renal Replacement Therapy, and Sepsis after Cardiac Surgery: The Roles of TIMP2*IGBP7 and Mid-Regional Pro-Adrenomedullin
Authors: Lacquaniti Antonio , Ceresa Fabrizio , Campo Susanna , Barbera Giovanna , Caruso Daniele , Palazzo Elenia , Patanè Francesco , Monardo Paolo
Published: July 2023

Identifying a panel of markers detecting kidney injury before the glomerular filtration rate (GFR) reduction is the challenge to improve the diagnosis and the management of acute kidney injury (AKI) in septic patients. This study evaluated the roles of tissue inhibitor metal proteinase, insulin growth factor binding protein (TIMP2*IGFBP7), and mid-regional pro-adrenomedullin (MR-proADM) in AKI patients. Patients and Methods: This study was prospectively conducted in the Intensive Care Unit (ICU) enrolling 230 patients who underwent cardiac surgery. Biomarkers were evaluated before and after 4 hours of the cardiac surgery. Results: Whereas urine and creatinine alterations appeared at 23.2 (12.7 – 36.5) hours, after cardiac surgery, urinary TIMP2*IGBP7 levels were higher at 4 hours in AKI patients (1.1±0.4 mg/l vs 0.08±0.02 mg/l; p < 0.001). Its concentration >2 mg/l increases the AKI risk within the following 24 hours, clearly identifying the population at high risk of renal replacement therapy (RRT). In patients with sepsis, MR-proADM levels were 2.3 nmol/l (0.7–7.8 nmol/l), with the highest values observed in septic shock [5.6 nmol/l (3.2–18 nmol/l)] and a better diagnostic profile than procalcitonin and C-reactive protein to identify septic patients. MR-proADM values >5.1 nmol/l and urine TIMP2*IGBP7 levels > 2 mg/l showed a significantly faster progression to RRT, with a mean follow-up time of 1.1 days. Conclusions: TIMP2*IGBP7 and MR-proADM precociously diagnose AKI in septic patients after cardiac surgery, giving prognostic information for RRT requirement.
Riveaux Road Fire Driven by Dynamic Winds in Tasmania, Australia
Authors: Ozaki Mitsuhiro , Williamson Grant , Fox-Hughes Paul , Love Peter , Aryal Jagannath
Published: July 2023

Background: We studied Riveaux Road Fire, which was ignited by multiple lightning strikes in January 2019 and burnt more than 637.19 km2 in southern Tasmania, Australia. Aims: We focused on fire weather, such as identification of dynamic wind and vegetation type, in a valley of the study area. Methods: We employed two methods: numerical weather model vertical sounding (NWMVS) and the use of a fire simulator, to quantify and examine the contribution of dynamic winds to fire behaviour. The NWMVSs allow rapid diagnosis of changes in wind, temperature, dew point temperature and cloud coverage. Prototype 2 is a fire simulator based on the specification of Australian Fire Danger Rating System (AFDRS). Key results: We found fires to be guided by terrain-forced channelling primarily and by downslope wind conditionally in the valleys. In addition, the fire intensity periodically changed with the magnitude of surface wind, in buttongrass moorland, in which the fire often smoulders, during the fire period according to the satellite image. Conclusions and Implications: Therefore, there should be caution for not only terrain and dynamic wind but also vegetation type during fire spread in rugged terrain.
Oxidation behavior at 1000°C of low–Mn high–Cr {Cantor’s HEA}–based alloys strengthened or not by MC carbides
Authors: Spaeter Pauline , Gay Corentin , Chenikha Nassima , Medjahdi Ghouti , Vernière Anne , Rapin Christophe , Aranda Lionel , Berthod Patrice
Published: July 2023

A conventionally cast CoNiFeMn0.5Cr1.5 alloy and two versions with 0.25C&3.7Ta or 0.25C&3.7Hf were tested in oxidation at 1000°C for 50h with thermogravimetric recording of the oxidation kinetic. In all cases the obtained mass gain curves are parabolic. Their parabolic constants are much lower than the Kp previously determined for the original alloys with an equimolar base (CoNiFeMnCr). However, the post–mortem exploitation of the oxidized samples revealed analogous oxidation features on surface and subsurface, with here too external oxide strata on surface with different Mn and Cr contents, and rather great Mn–depletion in addition to a moderate Cr–depletion, in subsurface. Globally, the oxidation behavior is significantly better than earlier observed for the equimolar version of these alloys.
Novel Method of Bauxite Treatment Using Electroreductive Bayer Process
Authors: Shoppert Andrei , Valeev Dmitry , Loginova Irina
Published: July 2023

Reductive leaching in the Bayer cycle using of iron (2+) allows Al extraction to be significantly increased by magnetization of Al-goethite and Al-hematite. However, the use of expensive iron (2+) salts or iron powder as a source of iron (2+) leads to a significant increase in production costs. In this work, the feasibility of a new method, the reductive leaching of bauxite using an electrolysis process, was investigated. Reduction of iron minerals of boehmitic bauxite in both Bayer solution and purely alkaline solutions were carried out. Experiments were performed using a plate cathode and a bauxite suspension in alkaline solution, as well as using a bulk cathode with a stainless-steel mesh at the bottom of the cell as the current supply. During the electrolysis process, the potential of the cathode relative to the reference electrode was measured as a function of current at different concentrations of solid (100-300 g L–1) and suspension temperatures (95-120 °C). It is shown that the current efficiency using suspension and plate cathode with the predominant deposition of Fe doesn’t exceed 50% even with the addition of magnetite to increase the contact of solid phase with the current supply. With the use of a bulk cathode, the reduction of iron minerals leads predominantly to the formation of magnetite with the efficiency of using electric current more than 80%. As a result of preliminary desilication and electroreduction it is possible to extract more than 97% of Al from bauxite, and to increase the iron content in the bauxite residue to 57-58%.
Just Keep Rolling? – An Encompassing Review towards Accelerated Vaccine Product Life Cycles
Authors: Stiefel Janis , Schloßhauer Jeffrey , Vosen Agnes , Kilz Sarah , Zimmer Jan , Balakin Sascha
Published: July 2023

In light of the recent pandemic, several COVID-19 vaccines were developed, tested and approved in a very short time, a process that otherwise takes many years. Above all, these efforts have also unmistakably revealed the capacity limits and potential for improvement in vaccine production. This review aims to emphasize recent approaches for targeted rapid adaptation and production of vaccines from an interdisciplinary multifaceted perspective. Using literature research, stakeholder analysis and a value proposition canvas, we reviewed technological innovations on the pharmacological level, formulation, validation and resilient vaccine production to supply bottlenecks and logistic networks. We identified four main drivers to accelerate the vaccine product life cycle: computerized candidate screening, modular production, digitized quality management and a resilient business model with corresponding transparent supply chains. In summary, the results presented here can serve as a guide and implementation tool for flexible, scalable vaccine production to respond swiftly to pandemic situations in the future.
Head and Neck Cancer in Pan-American Notable People: An International Survey
Authors: Martínez-Ramírez Josefina , Saldivia-Siracusa Cristina , Pérez-de-Oliveira Maria E. , Normando Ana Gabriela , Kowalski Luiz Paulo , Curado Maria Paula , Arboleda Lady Paola Aristizabal , Fernandes Gisele Aparecida , Cuadra-Zelaya Florence Juana María , Lopes Márcio Ajudarte , Magalhaes Marco A O , Sankar Vidya , Villa Alessandro , Santos-Silva Alan R.
Published: July 2023

The study of notable people as agents for increasing cancer awareness started just in the last decades of the 20th century. This study aimed to identify Pan-American notable people with head and neck cancer (HNC) and to assess HNC’s professional perspective on communicating stories of notable patients with HNC to promote prevention. Methods: This cross-sectional study was conducted by applying a RedCap questionnaire to oral medicinists, oral pathologists, head and neck surgeons, and clinical oncologists with experience in HNC research, education, or treatment in Pan-American countries. Additionally, a structured search was performed on PubMed, Scopus, EMBASE, Web of Science, LILACS, and gray literature Results: We identified 42 notable people from the United States, Brazil, Argentina, Mexico, El Salvador, Chile, Colombia, and Peru who were mainly actors, athletes, and musicians. Participants agreed that stories of notable patients with HNC can positively impact the population and promote prevention if communicated by the internet, social media, and television. Conclusion: In the Pan-American region, notable individuals who have suffered from HNC may be powerful advocates for increasing cancer awareness and promoting prevention strategies. The professionals involved in the study expressed a positive inclination towards using the stories of these notable HNC survivors as an effective prevention strategy.
Unravelling the Multiplicity of Geranylgeranylreductases (GGRs) in Archaea: Potential Roles in Saturation of Terpenoids
Authors: Rao Alka , Driessen Arnold JM
Published: July 2023

The enzymology of the key steps in the archaeal phospholipid biosynthetic pathway has been elucidated in recent years. In contrast, the complete biosynthetic pathways for proposed membrane regulators consisting of polyterpenes such as carotenoids, respiratory quinones and polyprenols remain unknown. Notably, the multiplicity of geranylgeranyl reductases (GGRs) in archaeal genomes has been correlated with the saturation of polyterpenes. Although GGRs, which are responsible for the saturation of the isoprene chains of phospholipids have been identified and studied in detail, there is little information regarding the structure and function of the paralogs. Here, we discuss the diversity of archaeal membrane-associated polyterpenes which is correlated with the genomic loci, structural and sequence-based analyses of GGR paralogs.
Large Language Models as Recommendation Systems in Museums
Authors: Trichopoulos Georgios , Konstantakis Markos , Alexandridis Georgios , Caridakis George
Published: July 2023

This paper proposes the utilization of large language models as recommendations systems for museums. Since the aforementioned models lack the notion of context, they can’t work with temporal information that is often present in recommendations for cultural environments (e.g. special exhibitions or events). In this respect, the current work aims at enhancing the capabilities of large language models through a fine-tuning process that incorporates contextual information and user instructions. The resulting models are expected to be capable of providing personalized recommendations, aligned with user preferences and desires. More specifically, Generative Pre-trained Transformer 4, a knowledge-based large language model is fine-tuned and turned into a context-ware recommendation system, adapting its suggestions based on user input and specific contextual factors such as location, time of visit, and other relevant parameters. The effectiveness of the proposed approach is evaluated through certain user studies, which ensure an improved user experience and engagement within the museum environment.
β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review
Authors: Nugraha Alexander Patera , Yang Hui , Chen Junduo , Yang Kunhua , Kraisintu Ploypim , Zaww Kyaw , Ma Aobo , Wang Ruixian , Alhadi Nada Emad Alshafei Mohamed , Vanegas Sáenz Juan Ramon , Hong Guang
Published: July 2023

The aim of this systematic review is to describe and to identify prospect of β-Tricalcium Phosphate (β-TCP) as Alveolar Bone Grafting (ABG) in Cleft Lip/Palate (CL/P) or alveolar bone cleft defect. A systematic review protocol based on Preferred Reporting Items for Systematic Reviews and Meta Analyses 2020 (PRISMA 2020) was drafted. The literature search was conducted with MEDLINE/PubMed, Web of Science/ ISI-Web of Knowledge, Scopus and Cochrane Library with English language and no publication year limits. The keywords yielded a total of 5824 publications. There are 3196 suitable articles to evaluate after removing duplicates and languages. Afterward, 1315 studies left after doing title and abstract reading. In addition, 85 full-articles were assessed for eligibility. The read the complete texts of those papers and eventually chose 20 that matched the inclusion requirements. Thirteen of the twenty studies included in this systematic review had a low risk of bias, one had a high risk of bias, and six had moderate bias which not report the randomization. β-TCP as ABG is biocompatible, visible and practical, offers a less invasive procedure, and does not interfere with orthodontic treatment. β-TCP as synthetic ABG can be the alternative to autologous bone grafts with several terms and conditions. Improvement of β-TCP efficacy for ABG in CL/P or alveolar bone cleft defects can be done by a tissue engineering approach combining β-TCP with growth factor, mesenchymal stem cells, or other graft materials and modification of β-TCP physical properties.
Monthly Precipitation Outlooks for Mexico Using ENSO Indices Approach
Authors: Gonzalez Miguel Angel , Suastegui Arturo Corrales
Published: July 2023

The socioeconomic sectors increasingly rely on prompt and affordable tools to predict climatic conditions. This study uses a decision tree classifier model to identify similar monthly ENSO 3.4 indices from March 2001 to February 2011 through monthly historical ENSO3.4 indices (December 1950 – February 2001). Historical monthly ENSO3.4 indices were used to extract available high-resolution monthly historical precipitation grids (1950-2001) for Mexico and constructed monthly ensembles (March 2001 – February 2011 hindcasts). Formerly, a precipitation categorization of monthly observed and simulated precipitation (2001-2011 hindcasts) was employed. Thereafter, global vector data and spatial map assessments were performed seasonally (winter, spring, summer, and fall). Global KSS and HSS metrics indicated the model approach has skill, especially in the spring and fall. Spatial metrics exposed large areas with hit rates > 0.60 in winter and spring, though in winter and spring (dry seasons), it was due to the precipitation categorization hindcast and observed were within the first classification. Lower hit rates, but still acceptable (> 0.40), were detected in summer and fall (during the rainy season and at the end, respectively) because more precipitation classifications were tested and prone to miss. Spatial Spearman correlations provided specific areas of significant model performances and found that high hit rates during the winter and spring are spurious. Meanwhile, it was also found that during the fall the model approach is reliable in most of Mexico, followed by the spring, and in constraint areas in summer and winter across the country. It also appears that dominant ENSO neutral events followed by balanced ENSO cooling and warming events do not prefer the model skill. Overall, the empirical method shows promise (low-cost human and computational resources if ENSO indices expose certainty in its Lead months to forecast) and has the potential to be used in other developing countries influenced by El Niño phenomena.
Do Sustainability Perceptions Affect Lake Destination Loyalty?
Authors: Ramazanova Makhabbat , Tortella Bartolomé Deyà , Kakabayev Anuarbek , Caldeira Ana Maria , Carneiro Maria João
Published: July 2023

Despite a growing concern over sustainability in tourism, research on this domain regarding, specifically, lake destinations, is still scarce. Although perceptions on lake destinations have been studied, no study is known that analyses the impact of visitors’ perceptions on satisfaction and behavioral intentions. Thus, this paper aims to develop and test a model to analyse the effect of lake visitors’ perceptions of destination’s sustainability on both satisfaction and loyalty towards lake destinations. A questionnaire survey was conducted in the Shchuchinsk-Burabay resort area, an important lake destination in northern Kazakhstan. The results support the proposed lake destination loyalty model, tested using partial least squares structural equation modelling (PLS-SEM). Sustainability proved to be decisively influential, with water quality being the dimension with the highest impact on satisfaction with the lakes, along with a positive key impact of the absence of congestion. In addition, both water quality and lack of congestion had a significant indirect impact on satisfaction with the lake destination, and on loyalty. Based on the research findings, theoretical conclusions and practical implications are drawn.
The Relationship between Personality Types, Coping, and Gender in Academic Stress
Authors: Varo Cristina , Aires-González María del Mar , García-Jiménez María , Trigo María Eva , Cano-García Francisco Javier
Published: July 2023

Some evidence suggests that personality types are a useful construct to understand stress and coping. However, further research is needed, especially on academic stress. Our aim was to explore how personality types and gender relate to coping strategies for academic stress and perceived coping efficacy. A total of 810 university psychology students completed the NEO-FFI Inventory and the Coping Strategies Inventory. Post-hoc tests for MANOVA and ANOVA were performed, where personality types and gender were treated as predictors and use of coping strategies and perceived coping efficacy as criteria. Finally, a one-way ANOVA followed by post hoc comparisons was performed to analyse the associations between personality types and perceived coping efficacy. Those with personality types combining low neuroticism with high conscientiousness chose the most adaptive coping strategies and showed the highest levels of perceived coping efficacy, while those whose personality types combined high neuroticism with low conscientiousness opted for maladaptive coping strategies and presented the lowest level of perceived coping efficacy. As for gender, women chose emotional expression more frequently. The personality type classification provided useful information on individual differences in coping with academic stress, which can help guide specific strategies to manage it.
Late Periprosthetic Femoral Stress Fracture Associated with Extra-articular Deformity in a Patient with Fibrous Dysplasia
Authors: Dozo Marcelo Adolfo , Abrego Mariano Oscar , Comba Fernando , Zanotti Gerardo , Buttaro Martín Alejandro , Slullitel Pablo Ariel
Published: July 2023

Case:

In the setting of a total hip arthroplasty performed in a patient with a proximal femoral deformity, atraumatic periprosthetic femoral stress fracture may arise as a complication. We report a rare case of a late periprosthetic femoral stress fracture around a cemented stem in a patient with a history of fibrous dysplasia of the proximal femur. After a 10-year uneventful period, the patient complained about a subtle, subacute pain in his left thigh induced by exercise but not with daily axial load. Diagnosis of a nondisplaced, incomplete (i.e., only compromising the lateral femoral cortex) periprosthetic femoral stress fracture was made with plain radiographs, blood work, and bone scintigraphy. Surgical treatment consisted of a minimally invasive plate osteosynthesis bridging the femoral deformity plus percutaneous osteoperiosteal decortication. At 5-year follow-up, the patient was asymptomatic with full return to physical activity, with radiographs evidencing callus formation.

Conclusion:

Stress fractures around well-fixed femoral stems, while infrequent, should be addressed in patients with a history of severe proximal femur deformity experiencing atraumatic thigh pain.
Knowledge, awareness, and use of folic acid among women of childbearing age living in a peri-urban community in Ghana: A cross-sectional survey
Authors: Harrison Obed Akwaa , Ifie Idolo , Nkwonta Chikere , Dzandu Bennett Atta , Gattor Albert Owusu , Adimado Emma Efua , Odoi Kafui Kofi , Aziavor Benedicta , Saalia Firibu Kwesi , Steiner-Asiedu Matilda
Published: July 2023

Background: Folic acid, a water-soluble B-complex vitamin, plays a crucial role in DNA synthesis and maintenance, making it particularly significant during reproduction. Its well-known ability to reduce the risk of congenital anomalies during the periconceptional period underscores its importance. The increased requirement for folate during pregnancy and lactation is essential to support the physiological changes of the mother and ensure optimal growth and development of the foetus and offspring. This study assessed the knowledge, awareness, and use of folic acid among pregnant and lactating women of reproductive age residing in Dodowa in the Shai Osu-Doku District, Accra, Ghana.
Methods: The study was a cross-sectional design that involved 388 randomly selected participants (97 pregnant and 291 lactating women). Structured questionnaires were administered to gather information on the socioeconomic demographic characteristics, knowledge, awareness, and use of folic acid of the participants. Dietary intake was assessed using a food frequency questionnaire. The data were analysed using descriptive statistics and Pearson's chi-square analysis tests and arepresented as frequencies and percentages, means, standard deviations, bar graphs, and pie charts. The significance of the results was determined at a 95% confidence interval.
Results: The mean age of the participants was 31±5.0 years. Among the study participants, 46.1% demonstrated knowledge of folic acid deficiency, while approximately 68.3% had a high awareness of folic acid supplementation. Approximately 75% of the participants indicated that they had not used folic acid supplements within the week, and 15.5% reported consuming folate-fortified food per week.
Conclusions: The women exhibited high awareness but poor knowledge regarding the usage of folic acid supplementation during pregnancy and lactation. Consequently, this lack of knowledge influenced the low use of folic acid supplements and low intake of folate-rich foods among pregnant and lactating mothers.
Functional integration of services during the antenatal period improves childhood growth parameters beyond infancy
Authors: Mehta Kayur , Mukherjee Sreeparna Ghosh , Bhattacharjee Ipsita , Fate Kassandra , Kachwaha Shivani , Rajeev Tushara , Kant Aastha , Banerjee Meghendra , Shet Anita
Published: July 2023

Background:
Despite progress, the prevalence of childhood undernutrition in India remains amongst the highest globally.
Objective:
We aimed to evaluate the impact of a functional integration interventional package during the antenatal period on childhood growth parameters.
Methods:
This is a post-interventional follow-up study of a maternal nutrition trial conducted between 2018–2019 among women in their first trimester of pregnancy from three districts in West Bengal, India. Those in the intervention group received a package that included body-mass-index measurement at pregnancy registration, monthly weight monitoring, targeted dietary counselling, supervised supplementary nutrition intake and iron-folic acid supplementation during daily anganwadi center visits. Age-matched pregnant women in the comparison group received standard-of-care. Maternal height and serial weights were recorded at antenatal visits, and birth and infant characteristics were noted. During the follow-up visit in 2021, child height and weight were measured. The relative risks of stunting, wasting and underweight were calculated using generalized linear models.
Results:
Eight-hundred-nine mother-child dyads (406 intervention; 403 comparison) were followed between May 2018 and May 2021. Median age of women in the intervention and comparison group was 23 (IQR 20–25) and 25 (IQR 24–27) years respectively. Median gestational-weight-gain was higher amongst intervention group women (9 vs. 8 kilograms, p = 0.04). Low-birth-weight prevalence was 29.3% (119/406) and 32.0% (129/403) in the intervention and comparison group. At 12–35 months of age, children born to women in the intervention group had significantly reduced risk of stunting (RR = 0.65, 95% CI 0.44–0.94), wasting (RR = 0.57, 95% CI 0.33–0.97) and underweight (RR = 0.61, 95% CI 0.42–0.88).
Conclusions:
These results indicate that functional integration and strengthening of routine antenatal care services including targeted nutritional counselling to expectant mothers can have distal beneficial effects on childhood undernutrition beyond the immediate post-natal period.
A hierarchical topic-guided BertCNN model for emotion classification from social network texts
Authors: Yang Yingyu , Huang Haiping , Chang Shuyu
Published: July 2023

Online public opinion management in the post-truth era is a comprehensive project, and emotion is the kernel of public opinion. Previous studies have begun to employ a combination of topic and semantic information from documents to improve the effectiveness of emotion classification. But efficiently extracting and combining this information remains a challenge. In addition, the widespread utilization of pre-trained models has given rise to many issues, including a large number of model parameters and extended training times. This paper presents a novel end-to-end hierarchical topic-guided BertCNN model(To-BertCNN) for emotion detection. The model utilizes a pruned hierarchical Bert model to extract semantic information at various levels within documents. Then a neural topic model is constructed to acquire topic embedding vectors. To-BertCNN finally employs a bi-directional attention fusion mechanism to fuse document vectors and topic features for emotion classification comprehensively. Experiments are conducted on three publicly available datasets, revealing that the classification performance of the To-BertCNN model surpasses that of the current state-of-the-art research, simultaneously enhancing the temporal efficiency of the model. The model fully adopts an end-to-end training approach, generating more coherent topic features and, consequently, higher interpretability.
Design and Evaluation of Periodic Mesoporous Organosilica/ZnO Nanocomposites as an Effective Drug Delivery System for Gemcitabine
Authors: Amirsoleimani Armin , Bahrami Zohreh , Kafshdouzan Khatereh
Published: July 2023

In this study, periodic mesoporous organosilica (PMO)/ZnO nanocomposites were synthesized and investigated as a delivery system for the anticancer drug (gemcitabine). The green synthesis of ZnO nanoparticles used rice bran extract. The characteristic results show that as ZnO concentration was increased, spherical particle size increased while surface area and pore volume decreased. Between two nanocomposites, the maximum gemcitabine loading content (53.1%) is related to the sample with the lowest concentration of ZnO nanoparticles. For all samples, the gemcitabine release at pH=5.6 is greater than pH=7.4. In the first eight hours, the rate of gemcitabine release was rapid; however, it gradually slowed down. The release kinetics were fitted with the Higuchi model. The MTT assay showed the cytotoxicity effect of the nanocomposites on human colon cancer cell lines (HT-29).