bluuebunny/crossref_metadata_2025 huggingface dataset:
Toward the Cure of All Children With Cancer Through Collaborative Efforts: Pediatric Oncology As a Global Challenge
Authors: Rodriguez-Galindo Carlos , Friedrich Paola , Alcasabas Patricia , Antillon Federico , Banavali Shripad , Castillo Luis , Israels Trijn , Jeha Sima , Harif Mhammed , Sullivan Michael J. , Quah Thuan Chong , Patte Catherine , Pui Ching-Hon , Barr Ronald , Gross Thomas
Published: August 2015

Advances in the treatment of childhood cancers have resulted in part from the development of national and international collaborative initiatives that have defined biologic determinants and generated risk-adapted therapies that maximize cure while minimizing acute and long-term effects. Currently, more than 80% of children with cancer who are treated with modern multidisciplinary treatments in developed countries are cured; however, of the approximately 160,000 children and adolescents who are diagnosed with cancer every year worldwide, 80% live in low- and middle-income countries (LMICs), where access to quality care is limited and chances of cure are low. In addition, the disease burden is not fully known because of the lack of population-based cancer registries in low-resource countries. Regional and ethnic variations in the incidence of the different childhood cancers suggest unique interactions between genetic and environmental factors that could provide opportunities for etiologic research. Regional collaborative initiatives have been developed in Central and South America and the Caribbean, Africa, the Middle East, Asia, and Oceania. These initiatives integrate regional capacity building, education of health care providers, implementation of intensity-graduated treatments, and establishment of research programs that are adjusted to local capacity and local needs. Together, the existing consortia and regional networks operating in LMICs have the potential to reach out to almost 60% of all children with cancer worldwide. In summary, childhood cancer burden has been shifted toward LMICs and, for that reason, global initiatives directed at pediatric cancer care and control are needed. Regional networks aiming to build capacity while incorporating research on epidemiology, health services, and outcomes should be supported.
Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial
Authors: Mao Jun J. , Bowman Marjorie A. , Xie Sharon X. , Bruner Deborah , DeMichele Angela , Farrar John T.
Published: August 2015

Purpose

Hot flashes are a common and debilitating symptom among survivors of breast cancer. This study aimed at evaluating the effects of electroacupuncture (EA) versus gabapentin (GP) for hot flashes among survivors of breast cancer, with a specific focus on the placebo and nocebo effects.

Patients and Methods

We conducted a randomized controlled trial involving 120 survivors of breast cancer experiencing bothersome hot flashes twice per day or greater. Participants were randomly assigned to receive 8 weeks of EA or GP once per day with validated placebo controls (sham acupuncture [SA] or placebo pills [PPs]). The primary end point was change in the hot flash composite score (HFCS) between SA and PP at week 8, with secondary end points including group comparisons and additional evaluation at week 24 for durability of treatment effects.

Results

By week 8, SA produced significantly greater reduction in HFCS than did PP (−2.39; 95% CI, −4.60 to −0.17). Among all treatment groups, the mean reduction in HFCS was greatest in the EA group, followed by SA, GP, and PP (−7.4 v −5.9 v −5.2 v −3.4; P = < .001). The pill groups had more treatment-related adverse events than did the acupuncture groups: GP (39.3%), PP (20.0%), EA (16.7%), and SA (3.1%), with P = .005. By week 24, HFCS reduction was greatest in the EA group, followed by SA, PP, and GP (−8.5 v −6.1 v −4.6 v −2.8; P = .002).

Conclusion

Acupuncture produced larger placebo and smaller nocebo effects than did pills for the treatment of hot flashes. EA may be more effective than GP, with fewer adverse effects for managing hot flashes among breast cancer survivors; however, these preliminary findings need to be confirmed in larger randomized controlled trials with long-term follow-up.
Equivalence Ratio for Daunorubicin to Doxorubicin in Relation to Late Heart Failure in Survivors of Childhood Cancer
Authors: Feijen Elizabeth A.M. , Leisenring Wendy M. , Stratton Kayla L. , Ness Kirsten K. , van der Pal Helena J.H. , Caron Huib N. , Armstrong Gregory T. , Green Daniel M. , Hudson Melissa M. , Oeffinger Kevin C. , Robison Leslie L. , Stovall Marilyn , Kremer Leontien C.M. , Chow Eric J.
Published: August 2015

Purpose

Cumulative anthracycline dose is one of the strongest predictors of heart failure (HF) after cancer treatment. However, the differential risk for cardiotoxicity between daunorubicin and doxorubicin has not been rigorously evaluated among survivors of childhood cancer. These risks, which are based on hematologic toxicity, are currently assumed to be approximately equivalent.

Patients and Methods

Data from 15,815 survivors of childhood cancer who survived at least 5 years were used. Survivors were from the Emma Children's Hospital/Academic Medical Center (n = 1,349), the National Wilms Tumor Study (n = 364), the St Jude Lifetime Cohort Study (n = 1,695), and the Childhood Cancer Survivor Study (n = 12,407). The hazard ratio (HR) for clinical HF through age 40 years for doses of daunorubicin and doxorubicin (per 100-mg/m2 increments) was estimated by using Cox regression adjusted for sex, age at diagnosis, treatment with other anthracycline agents and chest radiation, and cohort membership.

Results

In total, 5,144 (32.5%) patients received doxorubicin as part of their cancer treatment, whereas 2,243 (14.7%) received daunorubicin. On the basis of 271 occurrences of HF during a median follow-up time after cohort entry of 17.3 years (range, 0.0 to 35.0 years), the cumulative incidence of HF at age 40 years was 3.2% (95% CI, 2.8% to 3.7%). The average ratio of HRs for daunorubicin to doxorubicin was 0.45 (95% CI, 0.23 to 0.73). A similar ratio was obtained by using a linear dose-response model, which yielded an HR of 0.49 (95% CI, 0.28 to 0.70).

Conclusion

Compared with doxorubicin, daunorubicin was less cardiotoxic among survivors of childhood cancer than most current guidelines suggest. This may have implications for follow-up guidelines. The feasibility of substitution of doxorubicin with daunorubicin in childhood cancer treatment protocols to reduce cardiotoxicity should be additionally investigated.
Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration
Authors: Dome Jeffrey S. , Graf Norbert , Geller James I. , Fernandez Conrad V. , Mullen Elizabeth A. , Spreafico Filippo , Van den Heuvel-Eibrink Marry , Pritchard-Jones Kathy
Published: August 2015

Clinical trials in Wilms tumor (WT) have resulted in overall survival rates of greater than 90%. This achievement is especially remarkable because improvements in disease-specific survival have occurred concurrently with a reduction of therapy for large patient subgroups. However, the outcomes for certain patient subgroups, including those with unfavorable histologic and molecular features, bilateral disease, and recurrent disease, remain well below the benchmark survival rate of 90%. Therapy for WT has been advanced in part by an increasingly complex risk-stratification system based on patient age; tumor stage, histology, and volume; response to chemotherapy; and loss of heterozygosity at chromosomes 1p and 16q. A consequence of this system has been the apportionment of patients into such small subgroups that only collaboration between large international WT study groups will support clinical trials that are sufficiently powered to answer challenging questions that move the field forward. This article gives an overview of the Children's Oncology Group and International Society of Pediatric Oncology approaches to WT and focuses on four subgroups (stage IV, initially inoperable, bilateral, and relapsed WT) for which international collaboration is pressing. In addition, biologic insights resulting from collaborative laboratory research are discussed. A coordinated expansion of international collaboration in both clinical trials and laboratory science will provide real opportunity to improve the treatment and outcomes for children with renal tumors on a global level.
Transport of Iodothyronines by Human L-Type Amino Acid Transporters
Authors: Zevenbergen Chantal , Meima Marcel E. , Lima de Souza Elaine C. , Peeters Robin P. , Kinne Anita , Krause Gerd , Visser W. Edward , Visser Theo J.
Published: August 2015

Thyroid hormone (TH) transporters facilitate cellular TH influx and efflux, which is paramount for normal physiology. The L-type amino acid transporters LAT1 and LAT2 are known to facilitate TH transport. However, the role of LAT3, LAT4, and LAT5 is still unclear. Therefore, the aim of this study was to further characterize TH transport by LAT1 and LAT2 and to explore possible TH transport by LAT3, LAT4, and LAT5. FLAG-LAT1–5 constructs were transiently expressed in COS1 cells. LAT1 and LAT2 were cotransfected with the CD98 heavy chain. Cellular transport was measured using 10 nM 125I-labeled T4, T3, rT3, 3,3′-T2, and 10 μM [125I]3′-iodotyrosine (MIT) as substrates. Intracellular metabolism of these substrates was determined in cells cotransfected with either of the LATs with type 1 or type 3 deiodinase. LAT1 facilitated cellular uptake of all substrates and LAT2 showed a net uptake of T3, 3,3′-T2, and MIT. Expression of LAT3 or LAT4 did not affect transport of T4 and T3 but resulted in the decreased cellular accumulation of 3,3′-T2 and MIT. LAT5 did not facilitate the transport of any substrate. Cotransfection with LAT3 or LAT4 strongly diminished the cellular accumulation of 3,3′-T2 and MIT by LAT1 and LAT2. These data were confirmed by metabolism studies. LAT1 and LAT2 show distinct preferences for the uptake of the different iodocompounds, whereas LAT3 and LAT4 specifically facilitate the 3,3′-T2 and MIT efflux. Together our findings suggest that different sets of transporters with specific influx or efflux capacities may cooperate to regulate the cellular thyroid state.
Activin A Increases Human Trophoblast Invasion by Inducing SNAIL-Mediated MMP2 Up-Regulation Through ALK4
Authors: Li Yan , Klausen Christian , Zhu Hua , Leung Peter C. K.
Published: August 2015

Context:

Activin A increases matrix metalloproteinase (MMP) 2 expression and cell invasion in human trophoblasts, but whether the expression of MMP2 is essential for the proinvasive effect of activin A has yet to be determined. Moreover, the identity of the activin receptor-like kinase (ALK; TGF-β type I receptors) and downstream transcription factors (eg, SNAIL and SLUG) mediating the effects of activin on MMP2 expression and trophoblast cell invasion remains unknown.

Objective:

To elucidate the role of MMP2 in activin A-induced human trophoblast cell invasion as well as the involvement of ALK4 and SNAIL.

Design:

HTR8/SVneo immortalized human extravillous cytotrophoblast (EVT) cells and primary cultures of human first-trimester EVT cells were used as study models. Small interfering RNA (siRNA)-mediated knockdown approaches were used to investigate the molecular determinants of activin A-mediated functions.

Main Outcome Measures:

Levels of mRNA and protein were examined by reverse transcription-quantitative real-time PCR and Western blot, respectively. Cell invasiveness was measured by Matrigel-coated transwell assays.

Results:

Treatment of HTR8/SVneo cells with activin A increased the production of SNAIL, SLUG, and MMP2 without altering that of MMP9, TIMP1, TIMP2, TWIST, RUNX2, ZEB1, or ZEB2. Similarly, activin A up-regulated the mRNA and protein levels of SNAIL and MMP2 in primary EVT cells. Knockdown of SNAIL attenuated activin A-induced MMP2 up-regulation in HTR8/SVneo and primary EVT cells. In HTR8/SVneo cells, activin A-induced production of SNAIL and MMP2 was abolished by pretreatment with the TGF-β type I receptor (ALK4/5/7) inhibitor SB431542 or siRNA targeting ALK4, SMAD2/3, or common SMAD4. Likewise, knockdown of ALK4 or SMAD4 abolished the stimulatory effects of activin A on SNAIL and MMP2 expression in primary EVT cells. Importantly, activin A-induced HTR8/SVneo and primary EVT cell invasion were attenuated by siRNA-mediated depletion of ALK4 or MMP2.

Conclusion:

Activin A induces human trophoblast cell invasion by inducing SNAIL-mediated MMP2 expression through ALK4 in a SMAD2/3-SMAD4-dependent manner.
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus
Authors: Blessing Alicia M. , Ganesan Sathya , Rajapakshe Kimal , Ying Sung Ying , Reddy Bollu Lakshmi , Shi Yan , Cheung Edwin , Coarfa Cristian , Chang Jeffrey T. , McDonnell Donald P. , Frigo Daniel E.
Published: August 2015

Nuclear receptor (NR)-mediated transcriptional activity is a dynamic process that is regulated by the binding of ligands that induce distinct conformational changes in the NR. These structural alterations lead to the differential recruitment of coregulators (coactivators or corepressors) that control the expression of NR-regulated genes. Here, we show that a stretch of proline residues located within the N-terminus of androgen receptor (AR) is a bona fide coregulator binding surface, the disruption of which reduces the androgen-dependent proliferation and migration of prostate cancer (PCa) cells. Using T7 phage display, we identified a novel AR-interacting protein, Src homology 3 (SH3)-domain containing, Ysc84-like 1 (SH3YL1), whose interaction with the receptor is dependent upon this polyproline domain. As with mutations within the AR polyproline domain, knockdown of SH3YL1 attenuated androgen-mediated cell growth and migration. RNA expression analysis revealed that SH3YL1 was required for the induction of a subset of AR-modulated genes. Notable was the observation that ubinuclein 1 (UBN1), a key member of a histone H3.3 chaperone complex, was a transcriptional target of the AR/SH3YL1 complex, correlated with aggressive PCa in patients, and was necessary for the maximal androgen-mediated proliferation and migration of PCa cells. Collectively, these data highlight the importance of an amino-terminal activation domain, its associated coregulator, and downstream transcriptional targets in regulating cellular processes of pathological importance in PCa.
Thomas Rowlandson's Vauxhall Gardens: The Lives of a Print
Authors: Berg Temma
Published: August 2015

While there have been many reception studies of verbal texts, it is only recently that we have begun to explore the historical and cultural contexts of interpretations of eighteenth-century visual print culture. Given that Thomas Rowlandson's 1784 watercolor Vauxhall Gardens has become the definitive image of that famous pleasure garden, and has given rise to many complex and contradictory readings, a reception history of this beguiling print is long overdue. Tracing the print's reception from Henry Angelo, an old, school friend of Rowlandson's, through David Coke and Alan Borg's 2011 sumptuous cultural history of the gardens, this article concludes with a closer look at a version of the print that has only recently come to light. Part of the Paul Mellon Collection housed at the Yale Center for British Art, this image, perhaps a trial version, contains a surprising figure that is absent from the more familiar watercolor. At center left, just behind the figures that have often been identified as the Duchess of Devonshire and Lady Duncannon, stands a man who appears to be holding a drawing pad with which to capture the likeness of the viewer who stands before him, or, better yet, the likeness of the artist who faces the crowd and sketches the scene captured in Vauxhall Gardens, in other words, Rowlandson himself. An endless of hall of mirrors in which we can gaze at ourselves gazing at others gazing at us, Rowlandson's Vauxhall Gardens is indeed a print with many lives.
The yeast Pmp3p has a significant role in plasma membrane organization
Authors: De Block Julien , Szopinska Aleksandra , Guerriat Bérengère , Dodzian Joanna , Villers Jennifer , Hochstenbach Jean-François , Morsomme Pierre
Published: August 2015

Pmp3p-related proteins are highly conserved proteins that exist in bacteria, yeast, nematodes, and plants, whose transcript is regulated in response to abiotic stress such as low temperature or high salinity. Pmp3p was originally identified in S. cerevisiae where it belongs to the SNA (Sensitive to Na+) protein family which is composed of four members: Pmp3p/Sna1p, Sna2p, Sna3p, and Sna4p. Deletion of the PMP3 gene confers sensitivity to cytotoxic cations, while removal of the other SNA genes did not lead to clear phenotypic effects. It was long believed that Pmp3p-related proteins may have a common and important role in the modulation of plasma membrane potential and in the regulation of intracellular ion homeostasis. Here we show that several growth phenotypes linked to PMP3 deletion can be modulated by the removal of specific genes involved in sphingolipid synthesis. These genetic interactions, together with lipid binding assays and epifluorescence microscopy, as well as other biochemical experiments, suggest that Pmp3p could be part of a phosphoinositide-regulated stress sensor.
Rapid Determination of Reactivity of Natural Cellulose Pulp for Viscose Rayon by Diffuse Reflectance near Infrared Spectroscopy
Authors: Jie Ren , Hong-Fu Yuan , Chun-Feng Song , Jin-Chun Xie , Xiao-Yu Li , Jun-Qi Du
Published: August 2015

The reactivity of natural cellulose pulp is a key parameter in dissolving pulp in the viscose-fibre production process. Traditional analytical methods of the pulp are time-consuming, laborious and polluting. A rapid method for reactivity using a combination of near infrared diffuse reflectance spectroscopy and chemometrics is proposed in this paper. For this study, 92 samples of natural cellulose pulp (reactivity range 2 s to >250 s) were collected, and their reactivity values were determined as reference data by the standard method FZ/T 50010.13. A principal component analysis (PCA)-based model for distinguishing qualified samples from unqualified samples and a soft independent modelling of class analogy (SIMCA)-based model were constructed, respectively. The discrimination power of the SIMCA model was higher than that of the PCA model in all the samples. A quantitative calibration model of reactivity was established by PLS1 with a coefficient of determination of 0.84, standard error of calibration of 1.76 s, standard error of prediction of 2.12 s and ratio of prediction to deviation of 2.53. The new method is rapid, environmentally friendly, low cost and sufficiently accurate to be of value to the textile industry.
Behavior of a Novel Circular HSC Column with Double High Strength Spirals
Authors: Yang Fang , Sun Linzhu , Zhao Junliang , Wu Dongyan , Li Wei
Published: August 2015

During the last decades, great progress has been made in the research and application of high strength concrete (HSC). Due to its high strength, low dilation and brittle nature, substantial more transverse reinforcement is needed for HSC columns to obtain ductile behavior, especially for columns with large axial load ratio and/or located in seismic zones. In this paper, a novel HSC concrete column with double high-strength stirrups is proposed, which features two concentric transverse stirrups. The concrete in the cross section are divided into three parts under different confinement level, namely unconfined concrete, singly and doubly confined concrete. This structural form possesses many advantages over traditional HSC with single stirrup and steel-concrete composite columns, including enhanced strength and ductility, easy to construction and easy to connection with RC beams. Three demonstrative circular HSC columns with double spirals were prepared and tested under concentric axial compression. A current stress-strain model for steel confined HSC was modified and found suitable to predict the behavior of present HSC column with double spirals. A parametric study was then conducted to investigate the influence of several key parameters on load-strain response of HSC column with double spirals, including concrete strength, transverse reinforcement ratio, yield strength of transverse reinforcement and center to center diameter of inner spiral.
Fuzzy Similarity Approach for Ranking and Health Assessment of Towers Based on Visual Inspection
Authors: Verma Mohit , Rajasankar J. , Anandavalli N. , Prakash Amar , Iyer Nagesh R.
Published: August 2015

The most common way for the health assessment of existing telecommunication towers is through visual inspection. However, the results of the visual inspection are highly subjective and are merely based on perception which may differ grossly from one expert to another. One of the best ways to normalize human perception and reasoning in decision making is through fuzzy logic. This paper presents a fuzzy approach towards health assessment and ranking of telecommunication towers based on visual inspection. The health assessment of tower is treated as a group multicriteria decision making (MCDM) problem in which the towers are rated by expert group based on different criteria. The model used in the paper is a modified version of fuzzy technique for order preference by similarity to ideal solution (TOPSIS). The modified version rank the towers based on similarity with fuzzy positive ideal solution (FPIS) rather than the distance from fuzzy positive and negative ideal solutions. The model also provides critical information about the issues which need to be addressed to maintain the health of the towers and thereby enables efficient management and allocation of the limited resources. An illustrative example is included to clearly describe the steps involved in the process. Finally, sensitivity analysis for the model is carried out. The results of the sensitivity analysis demonstrate the tolerance of the model for slight variation in the input parameters, which typically reflect the doubt or confusion in the mind of expert while rating. The method is also compared with the closeness coefficient method and is found to be more appropriate for the ranking of towers. The model attempts to bring some rationality to the vagueness involved in visual inspection. The model is an effective tool for health assessment and ranking of towers based on visual inspection.
Effect of Random Distribution of Member Length Imperfection on Collapse Behavior and Reliability of Flat Double-Layer Grid Space Structures
Authors: Sheidaii Mohammad Reza , Gordini Mehrdad
Published: August 2015

The existence of initial imperfections in manufacturing of double-layer space structures having thousands of members is inevitable. Many of the imperfections, such as member length imperfections, are all random in nature. In this paper, the probabilistic effect of member length imperfection in the load bearing capacity of double-layer grid space structures with different types of supports have been investigated. First, for the member length imperfection of each member, a random number is generated from a normal distribution. Then, the imperfections are randomly distributed amongst the members of the structure. Afterwards, the ultimate bearing capacity of the structure is determined by using nonlinear analysis and this procedure is frequently repeated using Monte Carlo simulation method. Ultimately, based on the maximum values of bearing capacity, structure's reliability diagrams are obtained. The results show the sensitivity of the collapse behavior of double-layer grid space structures to the random distribution of initial imperfections.
Stochastic Optimal Control of Stayed Cable Vibrations with Wide-Band Random Wind Excitation Using Axial Support Motion
Authors: Fu Bing , Wang Zhenyu , Zhao Yan , Yang Liu
Published: August 2015

This paper proposes an optimal control strategy and corresponding method, to use the advantageous characteristics of the axial support motion to control the stayed cable vibrations in plane by wind excitation. Through a thorough investigation of wide-band random wind excitation and spatial relativity of the wind load along the cable, this study derives realistic and accurate motion equations of the control system. These motion equations are simplified into the form of the first four modes using the Galerkin method. The Itô stochastic differential equations of partial average for the system energy are derived using the stochastic averaging method of the quasi-integrable Hamiltonian systems. Furthermore, the dynamic programming equations with performance index are established by the stochastic dynamic programming principle. The random optimal control law is obtained by solving the dynamic programming equations using the approximate method. The numerical results show that, when standard deviations of the axial support motion are the same, the reduction of the standard deviation of the cable acceleration, and the cable displacement under the stochastic optimal control (SOC) law proposed by this paper, is larger than that under bilinear (BL) control. The SOC method proposed in this paper provides better results than the BL method.
Non-Linear Response to Periodic Forcing of Methane-Air Global and Detailed Kinetics in Continuous Stirred Tank Reactors Close to Extinction Conditions
Authors: Marra Francesco Saverio , Acampora Luigi , Martelli Emanuele
Published: August 2015

This paper focus on the behavior of a continuous stirred tank reactor (CSTR) subject to perturbations of finite amplitude and frequency. Two main objectives are pursued: to determine the extinction line in the equivalence ratio (φ) - residence time (τ) plane, fixed the thermodynamic state conditions; and to characterize the response of the chemical system to periodic forcing of the residence time. Transient simulations of combustion of methane with air, using both global single-step and detailed chemical kinetic mechanisms, have been conducted and the corresponding asymptotic solutions analyzed. Results indicate very different dynamical behaviors, posing the issue of a proper choice of the kinetic scheme for the numerical study of combustion oscillations.
Effects of Burner Configurations on the Natural Oscillation Characteristics of Laminar Jet Diffusion Flames
Authors: Manikantachari K. R. V. , Raghavan Vasudevan , Srinivasan K.
Published: August 2015

In this work, effects of burner configurations on the natural oscillations of methane laminar diffusion flames under atmospheric pressure and normal gravity conditions have been studied experimentally. Three regimes of laminar diffusion flames, namely, steady, intermittent flickering and continuous flickering have been investigated. Burner configurations such as straight pipe, contoured nozzle and that having an orifice plate at the exit have been considered. All burners have the same area of cross section at the exit and same burner lip thickness. Flame height data has been extracted from direct flame video using MATLAB. Shadowgraph videos have been captured to analyze the plume width characteristics. Results show that, the oscillation characteristics of the orifice burner is significantly different from the other two burners; orifice burner produces a shorter flame and wider thermal plume width in the steady flame regime and the onset of the oscillation/flickering regimes for the orifice burner occurs at a higher fuel flow rate. In the natural flickering regime, the dominating frequency of flame flickering remains within a small range, 12.5 Hz to 15 Hz, for all the burners and for all fuel flow rates. The time-averaged flame length-scale parameters, such as the maximum and the minimum flame heights, increase with respect to the fuel flow rate, however, the difference in the maximum and the minimum flame heights remains almost constant.
Tudo parou e não se podia dar o start: algo grave, muito grave, aconteceu!
Authors: Vieira Jailton Silva , Pereira de Araújo Maria Valéria
Published: August 2015

Matheus é protagonista da modernização de toda a logística da empresa, que está abandonando o sistema de armazenagem, distribuição e transporte existentes por outro maior, melhor, mais lucrativo e competitivo. Mas uma falha compromete todo o projeto e cria um enorme problema. A partir da descoberta dessa falha, a competência logística da empresa é colocada à prova e começa uma corrida contra o tempo para reverter um quadro desastroso.
Som Livre: mudar ou morrer?
Authors: Trinta José Luiz , Altaf Joyce Gonçalves , Abdalla Márcio Moutinho , Troccoli Irene Raguenet
Published: August 2015

O caso aborda as ações de mudança empreendidas pela gravadora Som Livre, dando ênfase ao seu novo modelo de negócios baseado na prestação de serviços. O principal foco é a necessidade da empresa de desenvolver um novo tipo de negócio, inteiramente distinto daquela que exercia há 35 anos.
Móveis RA e uma decisão comercial estratégica
Authors: Machado Rosimeri , Roesch Sylvia Maria Azevedo , Olea Pelayo Munhoz , Bertolla Fernando Luís , Nedeff Maurício Caetano
Published: August 2015

O caso aborda a estratégia comercial de uma empresa moveleira da serra gaúcha, frente a uma decisão a ser tomada com respeito à atuação no mercado internacional ou nacional. O objetivo é servir como instrumento de aprendizagem para disciplinas de análise e decisão estratégica, preferencialmente em cursos de graduação.
A trajetória internacional da Light Infocon
Authors: Cotta de Mello Renato , Da Rocha Angela , Maculan Anne Marie , Ferreira da Silva Jorge
Published: August 2015

O caso retrata a trajetória internacional de uma pequena empresa de software, a Light Infocon, sediada em Campina Grande, Paraíba, Brasil. A empresa tem presença virtual, física ou por meio de parceiros em vários mercados internacionais. O caso propõe à discussão uma avaliação das políticas e estratégias adotadas no processo de expansão internacional da empresa e se a continuidade dessas políticas e estratégias é apropriada no futuro. Recomenda-se a análise do caso à luz das teorias de empreendedorismo internacional, born globals e redes.
Chamada de Trabalhos - Negócios de Impacto Social
Authors: GVcasos Redação
Published: August 2015

A GVcasos oferece seu espaço para a divulgação de casos de ensino enfocando práticas no setor de negócios de impacto social. Submeta seu trabalho e divulgue a chamada entre seus colegas!
Casa de Banho e o desafio da responsabilidade social em micro e pequenas empresas
Authors: Nogueira Fernando do Amaral , Costa Cristina de Miranda
Published: August 2015

Os microempresários Patrícia e Fernando precisam decidir se dão seqüência ao incipiente programa de responsabilidade social de sua empresa. O caso ilustra os processos de gestão típicos de uma microempresa e tem como principal objetivo possibilitar a discussão das características e desafios da implementação de programas de responsabilidade social em empresas desse porte. DOI: 10.12660/gvcasosv5n1c2http://dx.doi.org/10.12660/gvcasosv5n1c2
Implantação de sistemas empresariais: um caso de resiliência ou teimosia?
Authors: Franco Eduardo Ferreira
Published: August 2015

A sobrevivência de uma empresa familiar de grande porte depende do sucesso de um processo de reestruturação. Apesar disso, a inciciativa foi até aqui conduzida como um projeto da área de TI e não da empresa.O caso aborda um contexto comum vivenciado por empresas de diferentes portes e segmentos que decidem lançar-se no desafio de aumentar sua eficiência e competitividade, tendo como um dos pilares desse processo a implantação ou revitalização de sistemas de informação.DOI: 10.12660/gvcasosv5n1c6http://dx.doi.org/10.12660/gvcasosv5n1c6
Fordlandia e Belterra: as cidades de Henry Ford na Amazônia (Notas de Ensino)
Authors: Duarte Jr. Antonio Marcos
Published: August 2015

DOI: 10.12660/gvcasosv5n1n1http://dx.doi.org/10.12660/gvcasosv5n1n1
Suspect, screen and sort – diagnosing COPD early
Authors: Scullion Jane , Holmes Steve
Published: August 2015

Early diagnosis is vital in helping a patient recover, write Jane Scullion and Steve Holmes
Diagnosis and management of polycystic ovary syndrome
Authors: Kochhar Suneeta
Published: August 2015

The condition is a factor in female subfertility, writes Suneeta Kochhar
Der deutsche Beitrag zur internationalen immobilienwirtschaftlichen Forschung
Authors: Pfnür Andreas , Kämpf-Dern Annette
Published: August 2015

Der vorliegende Beitrag gibt eine Übersicht über die bisherigen Inhalte immobilienwirtschaftlicher Forschung in Deutschland. Der Beitrag zeigt sowohl die Schwerpunkte als auch die weißen Flecken dieser Forschung im Inland und im internationalen Vergleich auf. Mit Hilfe des Konzepts der Familienähnlichkeiten und Kommensurabilität von Verhaltensannahmen gleichartiger Akteure wurden Cluster immobilienwirtschaftlicher Forschung gebildet. In einer empirischen Studie wurden 14.124 Forschungsbeiträge internationaler Konferenzen der IRES und AREUEA katalogisiert und den Forschungsclustern zugeordnet, deren deutscher Anteil im Fokus dieses Beitrags steht. Es zeigt sich, dass immobilienwirtschaftliche Forschung vor allem aus der Investorenperspektive betrieben wurde, wohingegen Themen aus Sicht der Immobiliennutzung und der Immobilienproduktion/-dienstleistungen weit weniger häufig Gegenstand der deutschen Forschung waren. Die Verteilung der Konferenzbeiträge auf die Cluster immobilienwirtschaftlicher Forschung in Deutschland ist eng korreliert mit der weltweiten Verteilung. Die Bewertung der praktischen Relevanz oder der konzeptionellen Qualität der Beiträge kann und soll durch die Untersuchung nicht vorgenommen werden. Jedoch können anhand der Ergebnisse individuelle Forschungsagenden validiert und gezielt z. B. in Richtung Mainstream oder Nische weiterentwickelt werden. Der Beitrag liefert somit einen innovativen Vorschlag zur Clusterung immobilienwirtschaftlicher Forschung und stellt zum ersten Mal ein umfassendes empirisches Bild über deren inhaltliche Ausrichtung in Deutschland im weltweiten Vergleich dar.
Avaliação da qualidade da água subterrânea: estudo de caso de Vilhena – RO
Authors: Oliveira Gislayne Alves , Do Nascimento Elisabete Lourdes , Denardin da Rosa Ana Lúcia , Lauthartte Leidiane Caroline , Bastos Wanderley Rodrigues , Barros Calina Grazielli Dias , Cremonese Eloiza Ruschel , Bento Amanda Quinhones , Malm Olaf , Georgin Jordana , Corti Adrielen Moraes
Published: August 2015

As águas subterrâneas do Aquífero Parecis (AP) representam a única fonte explorada para o abastecimento público de água potável do município de Vilhena - RO. Nesse sentido, a avaliação da qualidade da água determinada por análises físicas, químicas e microbiológicas, podem fornecer subsídios para a compreensão das condições da água consumida. No presente estudo, foram realizadas duas coletas de água subterrânea em 12 poços distribuídos na cidade: a primeira no período de estiagem (seca), em agosto de 2013; e a outra no período chuvoso, em dezembro de 2013. Os  parâmetros analisados foram os constituintes iônicos (F-, Cl-, NO2-,Br-,NO3-,PO4-3,SO4-2,Na+,NH3+, K+,Ca2+ eMg2+), os quais foram quantificados pela técnica de cromatografia iônica, enquanto que para as análises microbiológicas, o método utilizado foi o de membranas filtrantes em meio cromogênico. Os parâmetros pH e turbidez foram medidos por meio de pHmetro e turbidimetro portáteis. Os resultados apresentaram valores abaixo dos limites estabelecidos pela Resolução CONAMA 396/2008 e Portaria do MS 2.914/2011 para a turbidez e praticamente todos os constituintes iônicos, com exceção do nitrato (6 poços) e de amônia (1 poço), além de um pH ácido. O período chuvoso apresentou maior contaminação por coliformes totais e Escherichia coli que o período de estiagem, podendo estar associado às más condições dos poços, além de ser um aquífero livre, facilitando o escoamento de possíveis contaminantes. Em função dos resultados, destaca-se a importância do monitoramento constante da qualidade da água nas comunidades usuárias de fontes alternativas, evitando problemas à saúde humana
Memoria de la Especialización en Infancia, Cultura y Desarrollo. Discursos, saberes y prácticas, 1997-2014
Authors: Rincón verdugo Cecilia , Triviño Ana Virginia
Published: August 2015

Este artículo presenta los desarrollos de la investigación que desde la perspectiva histórico – interpretativa indagó por la trayectoria, por las relaciones entre los discurso y las prácticas; por los enfoques epistemológicos y metodológicos, y por la incidencia de la Especialización en Infancia, Cultura y Desarrollo en la formación de profesionales, así como por la transformación de las significaciones imaginarias que los estudiantes tienen sobre la infancia.

Metodológicamente este estudio se inscribe en la investigación cualitativa – documental, que propone describir y reconstruir analíticamente los discursos recogidos a través de las técnicas e instrumentos propuestos. La interpretación se realizó poniendo en diálogo los discursos que han circulado al interior de la Especialización y que componen el archivo documental (documentos, propuestas, tesis de grado, syllabus, programas y módulos) con los registros orales recogidos a través de las entrevistas que componen el archivo empírico (fuente oral), información que nos permitió develar los discursos, los saberes y las prácticas que han constituido la propuesta de formación y de investigación del posgrado.
Subclinical Cushing’s syndrome with bilateral adrenal tumours in a patient with gallbladder multiple stone: therapeutical options
Authors: Carsote Mara , Ghemigian Adina , Valea Ana , Dumitrascu Anda , Chirita Corina , Poiana Catalina
Published: August 2015

Introduction The field of Cushing syndrome is a various area; there are still subjects incompletely clarified as the subclinical pattern as well as cortisol producing bilateral adrenal tumours.

Case presentation The paper presents a 67-year old male case previously known with metabolic complications. He had an abdominal ultrasound done for unspecific complains and multiple gallbladder stones together with a right adrenal tumour were found. Later the computer tomography revealed bilateral adrenal tumours of almost 1.5 centimetres diameters (right larger than left) and a morning plasma cortisol level of 2.58 micrograms/ decilitre after low dose of dexametasone suppression test confirming the subclinical Cushing syndrome. After 6 months the endocrine and imagery profile was similar but the gallbladder patter aggravated so surgery was performed (together with right adrenalectomy) by a laparoscopic procedure. The blood pressure profile improved after surgery.

Conclusion Subclinical Cushing syndrome diagnosis is challenging especially if metabolic complications or bilateral adrenal tumours are presented. Based on our observations in this case unilateral adrenalectomy improved the metabolic pattern
Severe hepatocytolisis syndrome - a challenge in medical therapy of Cushing’s disease
Authors: Valea Ana , Carsote Mara , Ghemigian Adina , Morar Andra , Dumitru D.P. , Georgescu Carmen Emanuela
Published: August 2015

Introduction Cushing’s disease is a rare endocrine disorder characterized by persistent hypercortisolism due to excessive, autonomous ACTH secretion by a pituitary adenoma. Transsphenoidal adenomectomy is the main therapeutic option in Cushing’s disease. When imaging studies are unable to demonstrate an obvious pituitary mass complete tumor resection is difficult and often encumbered by risk of relapse. Medical therapy is a second-line option or the first-line treatment for patients with high surgical risk, incomplete surgical resection or relapse. Rarely classic clinical manifestations limit the selection of medical therapy for Cushing’s disease. Case presentation We present the case of a male patient with Cushing’s disease complicated with diabetes mellitus and severe hepatocytolisis syndrome with no visible pituitary adenoma on MRI studies. In the absence of technical equipment petrosal sinus sampling could not be performed in order to improve surgery outcome

Conclusion The presence of unbalanced diabetes and severe hepatocytolisis syndrome made it impossible to use steroidogenesis inhibitors (mitotane, ketoconazole, metyrapone, etomidate) or inhibitors of ACTH secretion as pasireotide that represent a new option in achieving control of hypercortisolism
From headache to Rathke’s cleft cyst followed by diabetes insipidus with panhypopituitarism
Authors: Valea Ana , Marcusan Alexandra , Carsote Mara , Ghemigian Adina , Ghervan Cristina , Dumitrache C.
Published: August 2015

Introduction The Rathke cyst represents an unusual benign tumour derived from Rathke’s cleft remnants. The diagnosis is potential seen at any age. The most frequent signs are mostly mass effects as headache, visual field defects and hypopituitarism.

Case presentation 30-year old female is admitted for persistent headache that was later associated with secondary amenorrhea and visual field defects for the last two years. The clinical data are consistent with high levels of serum prolactin, gonadotropes deficiency, as well as central hypothyroidism. The magnetic resonance imagery found a pituitary tumour of 2.7 centimetres with extrapituitary extension up to the optic chiasm. Surgery was performed in order to remove the tumour. The pathologic report confirmed a Rathke’s cleft cyst. Diabetes insipidus associated with panhypopituitarism was diagnosed and treated after the procedure. Close follow-up is necessary.

Conclusion This case highlights the fact that headache sometimes embraces a severe neoplasia diagnosis and that the iatrogenic complications after surgery are lifelong care demanding
Atherogenic index and coronarian risk – comparative assessment regarding the particularities of chronic autoimmune thyroiditis presence
Authors: Seceleanu Mihaela , Ibadula Sheila , Scrinic Olesea , Ganta Cristina , Circo E.
Published: August 2015

Objectives: Assessment of autoimmune cause hypothyroidism and dyslipidemia involvement in the apparition of major vascular complications. Methods: A total of 152 patients were investigated appreciating in comparison to a healthy control lot the hormone serum level, the presence of antimicrosomal thyroid antibodies and the serum levels of lipids. Atherogenic index and coronarian risk were calculated and correlated with the incidence of coronarian and cerebral vascular accidents. Results: Among the patients with goiter it was noted a high incidence of a subclinical hypothyroidism (31,58%). Thyroid autoimmunity was involved in 94,4% of the patients with clinical hypothyroidism, in 93,7 % with subclinical hypothyroidism and 100% in the patients with thyrotoxicosis. Low serum level of HDL-cholesterol was identified in 66,6% of patients with clinical hypothyroidism and 64,5% patients with subclinical hypothyroidism. The assessment of atherogenic index and coronarian risk was significantly higher (p<0,01) in patients with hypothyroidism in comparison to healthy control subjects. The incidence of vascular accidents was significantly higher (p<0,01) among the hypothyroid patients ( 19,7%/ 10,8%), of masculine gender (12,7%) where the main cause of hypothyroidism was autoimmunity. Conclusions: The atherogenic index and coronarian risk were higher in patients with hypothyroidism associated to thyroid autoimmunity resulting in an increased probability in producing vascular accidents
Graves Disease And Down Sindrome : Clinical Case
Authors: Scrinic Olesea , Ibadula Seila , Circo E.
Published: August 2015

Introduction: Pacients with Down’s syndrome present an increase revalence of autoimune endocrine disorders. We communicate the case of 14 years and 6 months old pacient known with Down syndrome admitted in Endocrinology department with suspicion of hyperthyroidism, the diagnosis being confirmed by hormonal dosage. The particularity of the case consists in: symptomatology onset during puberty, clinical evolution with mild symptoms, without ocular involvement, morphological and functional remission obtained relatively soon after the initiation of antithyroid therapy, lack of posttherapy side effects, favorabile evolution under the “block and replace” therapy
Obama’s Dual Discourse on American Exceptionalism
Authors: Hrnjaz Miloš , Krstić Milan
Published: August 2015

This paper analyses the highly contested concept of American exceptionalism, as described in the speeches of Barak Obama. The authors of the paper use discourse analysis to show that Obama is using the idea of American exceptionalism on two levels: US foreign policy and the US stance towards international law. Our conclusion is that Obama uses an implicit dual discourse in both these fields. Obama favours active US foreign policy, based on soft power instruments and multilateralism. He insists that American exceptionalism does not mean that the US can exempt itself from the norms of international law, however, he does not think the US should always have a very active foreign policy. He makes room for unilateral acting and the use of hard power instruments in foreign policy. He allows for the use of force even if is not in accordance with the norms of international law, when US national interests are threatened.
Separable monoids in Dqc
(X)
Authors: Neeman Amnon
Published: August 2015

Suppose

(
𝒯
,
⊗
,
𝟙
)

{({\mathscr{T}},\otimes,\mathds{1})}

is a tensor triangulated category. In a number of
recent articles Balmer defines and explores the notion of “separable
tt-rings” in

𝒯

{{\mathscr{T}}}

(in this paper we will call them “separable
monoids”). The main result of this article is that, if

𝒯

{{\mathscr{T}}}

is the derived quasicoherent category of a noetherian scheme X, then
the only separable monoids are the pushforwards by étale maps
of smashing Bousfield localizations of the structure sheaf.
Korovkin Type Theorem for Sequences of Operators Depending on a Parameter
Authors: Finta Zoltán
Published: August 2015

We establish necessary and sufficient conditions for a parameter depending sequence (L
Certain Generalized q-Operators
Authors: Prakash Om , Sharma Diwaker , Maheshwari Prerna
Published: August 2015

The applications of q-calculus in the approximation theory is a very interesting area of research in the recent years, several new q-operators were introduced and their behaviour were discussed by many researchers. This paper is the extension of the paper [15], in which Durrmeyer type generalization of q-Baskakov-Stancu type operators were discussed by using the concept of q-integral operators. Here, we propose to study the Stancu variant of q-Baskakov-Stancu type operators. We establish an estimate for the rate of convergence in terms of modulus of continuity and weighted approximation properties of these operators.
Fixed Point Theorems on Generalized Metric Spaces for Mappings in a Class Of Almost φ-Contractions
Authors: Kikina Luljeta , Kikina Kristaq
Published: August 2015

In this paper, we obtain some new fixed point theorems in generalized metric spaces for maps satisfying an implicit relation. The obtained results unify, generalize, enrich, complement and extend a multitude of related fixed point theorems from metric spaces to generalized metric spaces.