bluuebunny/crossref_metadata_2025 huggingface dataset:
Augmented Memory: Capitalizing on Experience Replay to Accelerate De Novo Molecular Design
Authors: Guo Jeff , Schwaller Philippe
Published: May 2023

Sample efficiency is a fundamental challenge in de novo molecular design. Ideally, molecular generative models should learn to satisfy desired objectives under minimal oracle evaluations (computational prediction or wet-lab experiment). This problem becomes more apparent when using oracles that can provide increased predictive accuracy but impose a significant cost. Molecular generative models have shown remarkable sample efficiency when coupled with reinforcement learn- ing, as demonstrated in the Practical Molecular Optimization (PMO) benchmark. Here, we propose a novel algorithm called Augmented Memory that combines data augmentation with experience replay. We show that scores obtained from oracle calls can be reused to update the model multiple times. We compare Augmented Memory to previously proposed algorithms and show significantly enhanced sample efficiency in an exploitation task and a drug discovery case study requiring both exploration and exploitation. Our method achieves a new state-of-the-art in the PMO benchmark which enforces a computational budget, and outperforms the previous best performing method on 19/23 tasks.
Quantifying and modulating protein encapsulation in guanosine-based supramolecular particles
Authors: Prieto-Costas Luis A. , Rivera-Cordero Génesis R. , Rivera Jose M.
Published: May 2023

The encapsulation of proteins is an effective way to preserve their structure and enhance their function. One exciting possibility is adjusting the protective agent to match the specific protein's characteristics to influence its properties. In a recent study, we developed a flow cytometry-based method to quantify the encapsulation of small molecule dyes in colloidal particles made from guanosine derivatives (SHS particles). We aimed to determine if this method could quantify protein encapsulation and track changes and if proteins could be tuned to bind to these particles. Our results showed that FITC-labeled proteins had apparent association constants in the micromolar range, with hydrophobicity as the dominant factor enhancing the affinities. Confocal laser scanning microscopy imaging supported these results and provided additional information about protein distribution within the particles. We also tested the feasibility of tuning avidin affinity (AVI) for SHS particles with a biotin ligand. We found that increasing the amount of biotin initially enhanced AVI binding, but then reached saturation, which we hypothesize results from non-covalent cross-linking caused by strong biotin/AVI interactions. CLSM images showed that the linker also impacted AVI distribution within the particles. Our strategy provides an advantage over other methods for quantifying protein encapsulation by being suitable for high-throughput analysis with high reproducibility. We anticipate that future efforts of using lower affinity ligands would result in better strategies for modulating protein affinity for drug-delivery applications.
Statistics and Bias-Free Sampling of Reaction Mechanisms from Reaction Network Models
Authors: Rappoport Dmitrij
Published: May 2023

Selection bias is inevitable in manually curated computational reaction databases but can have a significant impact on generalizability of quantum chemical methods and machine learning models derived from these data sets. Here, we propose quasireaction subgraphs as a discrete, graph-based representation of reaction mechanisms that has a well-defined associated probability space and admits a similarity function using graph kernels. Quasireaction subgraphs are thus well suited for constructing representative or diverse data sets of reactions. Quasireaction subgraphs are defined as subgraphs of a network of formal bond breaks and bond formations (transition network) composed of all shortest paths between reactant and product nodes. However, due to their purely geometric construction, they do not guarantee that the corresponding reaction mechanisms are thermodynamically and kinetically feasible. As a result, a binary classification of feasible (reaction subgraphs) and infeasible (non-reactive subgraphs) must be applied after sampling. In this paper, we describe the construction and properties of quasireaction subgraphs and characterize the statistics of quasireaction subgraphs from CHO transition networks with up to six nonhydrogen atoms. We explore their clustering using Weisfeiler--Lehman graph kernels.
Computational Communication Studies in Chineseand English: Issues, Methods and Theories
Authors: Zhong Zhijin , Zhou Jinjin , Su Sini
Published: May 2023

以中西方新闻传播学领域重要学术期刊为来源,本研究从“议题”“方法”“理论”三个维度对2022年计算传播研究进行了系统回顾,并比较了中西方文献侧重点的异同。研究发现,在议题选择上,政治传播是中西方学者共同关注的热门领域,此外,英文文献对疫情、新闻业领域的研究注意力较高。研究方法层面,新浪微博则构成中文文献的主要数据来源。英文文献中,Twitter、Facebook和新闻报道是最主流的数据来源,也出现跨平台获取数据以及大小数据结合的前沿研究。语义分析、网络分析和情感分析是中英文文献都常用的计算方法,视觉分析和仿真模拟得到初步应用,西方文献开始引入屏幕组学的研究方法。
Towards Practice in Journalism Studies with Chinese Characteristics
Authors: Bai Hongyi , Ma Jinhui
Published: May 2023

本研究对2022年刊发于 CSSCI来源期刊上的新闻学论文进行了文本细读,提炼出新闻学范式变更的四类“征兆”———走向后人类、走向后现代、走向社会关系网络、走向意识形态,并展示了上述征兆如何体现在理论和实践两个研究维度。这些征兆既显示了中国新闻学内部的动荡与危机,也预示着其将要走上的新突破道路,而中国特色新闻学要想真正走向新时代历史唯物主义的实践,则要深刻地从这些“征兆”的内部逻辑对其做出回应。
Cinema Studies and Pan-Cinema Studies —— An Overview of International Cinema Studies(2020—2022)
Authors: Hao Wanquan , Yin Hong
Published: May 2023

电影，作为全球性、大众性、高影响力的媒介、媒介内容和媒介产业，有两个研究维度，“对电影的研究”和“关于电影的研究”。通过对2020—2022这三年的SSCI、AHCI数据库的检视，以史料发现、历史建构、媒介考古作为研究方法研究作为媒介与艺术的电影史，以探讨影像与现实、历史、社会的指涉关联研究作为文本的电影，以对数字技术、流媒体的未来学思考研究作为工业的电影，以国族想象、地缘政治、跨文化传播等视野的拓展研究作为全球和区域文化的电影，四个方面构成了我们所理解的国际电影研究的重要议题。电影研究，不仅仅是“对电影”的研究，更是“通过电影”进行的对历史与社会、艺术与技术、大众与生活的研究。
Stability of 2-variable additive-quadratic-cubic-quartic functional equation using fixed point method
Authors: M. Arunkumar  , S. Karthikeyan  , S. Hemalatha
Published: May 2023

In this paper, the authors proved the generalized Ulam-Hyers stability of 2-variable Additive-QuadraticCubic-Quartic functional equation$$\begin{aligned}f(x+2 y, u+2 v)+f(x-2 y, u-2 v)= & 4 f(x+y, u+v)-4 f(x-y, u-v)-6 f(x, u)+f(2 y, 2 v) \\& +f(-2 y,-2 v)-4 f(y, v)-4 f(-y,-v)\end{aligned}$$using fixed point method.
On two boundary-value problems of functional integro-differential equations with nonlocal conditions
Authors: A. M. A. El-Sayed  , M. SH. Mohamed  , K. M. O. Msaik
Published: May 2023

In this paper we establish the existence of solution for two boundary value problems of Fredholm functional integro-differential equations with nonlocal boundary conditions.
$a_i $ Type n - variable multi n-dimensional additive functional equation
Authors: Matina J. Rassias  , M. Arunkumar  , E. Sathya
Published: May 2023

In this paper, the authors investigated the general solution and generalized Ulam - Hyers stability of $a_i$ type $n$ - variable multi $n$ - dimensional additive functional equation$$\begin{aligned}2 h\left(\sum_{i=1}^n a_i x_{1 i}\right. & \left., \sum_{i=1}^n a_i x_{2 i}, \ldots \ldots, \sum_{i=1}^n a_i x_{n i}\right) \\= & \left(\sum_{i=1}^n a_i\right) h\left(\sum_{i=1}^n x_{1 i}, \sum_{i=1}^n x_{2 i}, \ldots \ldots, \sum_{i=1}^n x_{n i}\right) \\& +\left(a_1-\sum_{i=2}^n a_i\right) h\left(x_{11}-\sum_{i=2}^n x_{1 i}, x_{21}-\sum_{i=2}^n x_{2 i}, \ldots \ldots, x_{n 1}-\sum_{i=2}^n x_{n i}\right)\end{aligned}$$where $a_i(i=1,2, \ldots n)$ are different integers greater than 1 , using two different technique.
Patient Safety Risks and Measures for Pediatric Neurosurgery Nursing
Authors: Jiang Lili , Yang Weifang , Zhang Song
Published: May 2023

The aim of this study was to determine the patient safety risks and measures for pediatric neurosurgery nursing. A total of 564 pediatric patients admitted to the hospital from June 2020 to June 2023 under the neurosurgery department were included in this study. We analyzed the safety incidents in pediatric neurosurgery nursing and their causes and proposed corresponding measures for pediatric neurosurgery nursing in hope to reduce the occurrence of patient safety incidents in pediatric neurosurgery nursing and establish harmonious nurse-patient relationships.
Determination of Optimum Programmed Temperature for Fatty Acid Analysis of Chlorella Microalgae Extract Using GCMS Instrument
Authors: Surani Surani , Pujiasmoro Cahyo , Kadarohman Asep
Published: May 2023

Suhu kolom Gas Chromatography-Mass Spectrometry (GCMS) merupakan salah satu variabel yang harus diperhatikan pada analisis senyawa kimia, agar senyawa terpisahkan dengan baik. Penelitian ini bertujuan untuk menentukan suhu terprogram optimum pada analisis asam lemak menggunakan instrumen GCMS. Sampel asam lemak yang digunakan berasal dari hasil ekstrak  mikroalga Chlorella. Ekstrasi mikroalga Chlorella dilakukan dengan cara sonikasi selama 60 menit menggunakan pelarut n-heksana. Variasi suhu terprogram GCMS yang dilakukan, yaitu kenaikan suhu masing-masing pada 5 OC/menit, 7 OC /menit, 9 OC /menit, 12 OC /menit dengan suhu awal 80 OC dan suhu akhir 270 OC. Jumlah sampel yang diinjeksikan sebanyak 0,2 µL. Data hasil analisis diolah dengan cara membandingkan waktu retensi dan lama waktu analisis. Ditemukan, kondisi optimum suhu terprogram pengukuran, yaitu suhu awal 80 OC dan kenaikan 9 OC/menit sampai suhu 270 OC dengan lama waktu analisis 21,1 menit. Asam lemak yang terkandung dalam ekstrak mikroalga Chlorella yaitu asam palmitat, asam oleat dan asam stearat. Dengan menggunakan metode pengukuran ini waktu analisis menjadi lebih singkat dan senyawa yang diharapkan dapat teridentifikasi dengan baik. ;
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Kata kunci: Analisis,  GCMS, suhu terprogram, asam lemak, mikroalga Chlorella.
A Comparative Analysis of Groundwater Vulnerability and PFAS Contamination in Maine
Authors:   , Boesch Dining Eli
Published: May 2023

As more information is learned regarding the long-term health effects of per- and polyfluoroalkyl substances (PFAS), increasing regulatory measures are being taken to protect the public from these chemicals. States like Maine are on the forefront of such legislation, banning land-applied biosolids in 2022 for fear of PFAS contamination, with plans to halt sales of all unnecessary PFAS products in the state by 2030. The state has conducted some testing of groundwater supplies, but the near-ubiquitous nature of PFAS in manufacturing indicates contamination may be widespread. To prioritize testing in Maine’s most vulnerable aquifers, a groundwater susceptibility map has been developed using a modified form of the EPA’s DRASTIC model. The model uses geological, atmospheric, and land use data to estimate the relative vulnerability of groundwater across the state. Additionally, a heatmap of potential PFAS sources was created, where each site was assigned a risk score based on the upper magnitude of PFAS contamination associated with its industry. These maps were compared with state PFAS test results to determine the validity of each method. Regional vulnerability trends were found which indicate karst features, coarse glacial/fluvial deposits, volcanic geology, and urban development are signs of high groundwater vulnerability. Density of potential PFAS sources was also found to be highest around urban centers, with PFAS test data affirming the relationship. Recommendations are made for best management practices guided by the models, such as protection of the most vulnerable aquifers via rezoning and building factories on impermeable geologies. Future model development is encouraged with more robust datasets and additional fine-tuning of the statewide Depth to Groundwater, Depth to Bedrock, and Hydraulic Conductivity maps.
Associations of somatotropin (GH) gene polymorphism with lactation performance of cows
Authors: Yaryshkin A. A. , Shatalina O. S. , Tkachenko I. V. , Leshonok O. I.
Published: May 2023

The research was conducted in the laboratory of molecular genetic expertise in 2018 and 2019 within the framework of the state assignment on the topic "Development of genetic-selection and theoretical foundations for the conservation and effective use of the gene pool of cattle in the Ural region with the use of modern biotechnologies". The object of the study is the cattle of Holsteinized black-and-white breed. The main task is to analyze the degree of influence of the somatotropin (GH) gene polymorphism on lactation performance indicators. In the course of the study, DNA from 270 cows was isolated, the polymorphism of the somatotropin gene was determined based on the obtained data, and the relationship between different genotypes and indicators of live weight, milk yield, protein mass fraction and fat mass fraction in milk was established. The results were biometrically processed using IBM SPSS Statistics 23 software program. It was revealed that LL is the main genotype of the GH gene among the representatives of the Holsteinized black-and-white breed (frequency of occurrence 77.0%). The proportion of LV and VV genotypes in the population is 21.9 and 1.1%, respectively. During the observation period, cows carrying the LL genotype showed higher milk yields in the first and third lactations. The difference with their peers was 202-2334 kg (p ≤ 0.05). A tendency towards increased protein content in milk was recorded in animals with the VV genotype. In the first lactation, the difference with LL and LV genotype carriers was 0.03 and 0.06%, respectively. In the third lactation, individuals with the VV genotype surpassed their female counterparts in protein content by 0.07 and 0.12%, respectively.
Stripping as a snow retention method in the steppe conditions of Western Siberia
Authors: Chekusov M. S. , Yushkevich L. V. , Mikhaltsov E. M. , Kem A. A. , Damansky R. V. , Schmid A. N. , Yushchenko D. N.
Published: May 2023

The process of snow cover formation on the fields with different surface conditions was studied. The research was conducted in the spring of 2022 in the steppe farming zone of the Omsk region. The effect of high plant stand of cereal crops remaining after harvesting by standing crop stripping on the amount of snow cover and the volume of spring moisture accumulation in the soil as a reserve for increasing the yield in the steppe regions of Western Siberia is considered. The results of determining the height of snow cover on a fallow field (complete fallow), on fields under grain crops harvested by different methods: with a direct harvester followed by flat tillage; with a direct harvester without subsequent tillage; with a combing harvester at the height of the stem during harvesting up to 0.55 m are presented. In the course of the study it was found that during harvesting by the stripping method, the moisture reserves in the snow cover were 2.2 times higher compared to the stubble background, 3.7 times higher compared to the stubble background treated with a flat cutter, and 4.1 times higher compared to the fallow field (control). Based on the data obtained, the conclusion is made about the possibility of using this method to form the conditions for moisture accumulation in the arid steppe zone without additional measures for snow retention, which should have a positive impact not only on the yield of cultivated crops, but also on the agro-economic indicators.
Distribution of the adventive species Galinsoga parviflora and G. guadriradiata (Asteraceae) in the south of the Far Eas
Authors: Fedina L. A. , Malysheva S. K.
Published: May 2023

The results of the study of the stranger American species Galinsogaparviflora and G. guadriradiata in the south of the Primorsky Territory (Russia) are presented. Field studies were conducted in 20182022 on the territory of the Primorsky Territory in urban and rural settlements, in specially protected natural areas (V.L. Komarov Ussurisky Nature Reserve). Literary data, information from Internet resources, herbarium specimens have been analyzed. Studies have found that over the past 30 years, the invasive range of species of the genus Galinsoga in the south of the Far East has increased significantly. At present, in the Primorsky Territory, these adventive species actively disperse over anthropogenically transformed territories (roadsides, abandoned fields and meadows, city parks and squares, adjacent territories, construction pits, etc.) and are noted in most administrative-territorial districts of the region. Galinsoga species have a sporadic distribution in the northern and eastern parts of the region. G. guadriradiata and G. parviflora grow en masse in the areas with developed agriculture (western and central Primorsky Territory). In Vladivostok, several large herbaceous communities are noted with dominance of G. guadriradiata, up to 100 m² in area with projective coverage of 90-100%. The penetration of species of the genus Galinsoga into specially protected natural areas is of great concern. Therefore, further monitoring of the invasive range of these species in the south of the Russian Far East is necessary.
Mathematical modelling of the manganese level in the muscle tissue of cattle
Authors: Narozhnykh K. N.
Published: May 2023

The results of determining the most effective model for predicting the level of manganese in the muscle tissue of Hereford cattle for in vivo assessment of the elemental status of animals by low invasive methods are presented. The experiment was carried out using hematological and biochemical blood tests and atomic absorption analysis of the muscle tissue of cattle. The data obtained are used to fit the regression model using the least square method. Skeletal muscle samples weighing 100 g from the diaphragm muscle of the Hereford cattle bred in the southern part of Western Siberia in the conditions of industrial complex were taken for analysis. Manganese concentration in tissues was assessed by atomic absorption analysis on an MGA-1000 spectrometer. The content of erythrocytes, leukocytes, and hemoglobin was determined on an automatic hematology analyzer PCE-90VET. Protein, albumin, globulin, urea, uric acid, and cholesterol levels were determined by photometric methods on a Photometer-5010 semi-automatic biochemical analyzer. The effects of regression models were calculated using the least square method. Selection of the best model for efficiency and accuracy of model estimation was based on a comprehensive assessment of the values of internal and external quality criteria. Statistically significant associations (p < 0.05) were found between the dependent and independent variables. Within the pool of predictors, correlation (p < 0.05) was observed. As a result of model fitting, an optimal regression equation including two indicators (erythrocyte sedimentation rate and globulin level) for predicting manganese levels in bovine muscle tissue was obtained. There are no signs of multicollinearity between the main effects of the model, which confirms the values of the variance inflation factor 1.2. The resulting model satisfies the necessary assumptions about the residuals. The distributions of the model residuals fall within the confidence intervals of the normal distribution curve. The autocorrelation coefficient was 0.039 (p > 0.05), indicating the independence of the residuals. The resulting model can be used for in vivo assessment of manganese concentration in bovine muscle tissue.
The Effect of Financial Performance on Market to Book Value of Equity (MBVE) in LQ45 Companies on the IDX Post Pandemi Covid 19
Authors: Febriani Lia , Sukoco Agus
Published: May 2023

This study aims to test and prove whether financial performance affects the market to book value of equity (MBVE). The population in this study are all LQ45 companies listed on the IDX for the 2019-2021 period. Sampling was carried out by purposive sampling and 135 companies were selected. The data in this study come from secondary data obtained through documentation techniques. Data analysis with multiple regression partially using SPSS. The results showed that simultaneously there was a significant effect of CR, DER, and ROA on MBVE. Based on partial testing, it is concluded that CR, DER and ROA have a significant effect on MBVE.
On the Jost Solutions of A Class of the Quadratic Pencil of the Sturm-Liouville Equation
Authors: ADİLOĞLU Anar , CÜCEN Döndü Nurten
Published: May 2023

In this study we construct new integral representations of Jost-type solutions of the quadratic pencil of the Sturm-Liouville equation with the piece-wise constant coefficient on the entire real line. Our aim is to express the special solutions of the Sturm-Liouville quadratic pencil in the form of some integral operators which kernels is related with the potential function of the Sturm-Liouville equation. This problem is technically diffucult due to the discontinous coefficient which causes the kernel function to also have a jump discontinuity.
PEMBERDAYAAN MASYARAKAT MELALUI PELATIHAN PEMBUATAN DAN PEMASARAN DOMER (DODOL MELINJO AREN) DI DESA PUSUK LESTARI KABUPATEN LOMBOK BARAT
Authors: Sari Neti Kumala , Diniyatushoaliha Ainun , Nurhidayat Nurhidayat , Yusniati Baiq Kayul Putri , Wulandari Nur , Saputra Hendra , Fathoni Rohiana , Khadijah Khadijah , Istiarini Yunita , Reksi Ni Kadek Dwi Okta Virana , Amrullah Amrullah
Published: May 2023

Pusuk Lestari Village is one of the villages in Batu Layar District, West Lombok Regency. The majority of Pusuk Lestari Village residents work as traders and farmers. After conducting a survey, residents in Pusuk Lestari Village have abundant natural resources but a lack of processing skills is a problem in the village. It can be said that the people in the village are not able to take advantage of the abundant natural products, so it is necessary to take innovative steps that can be applied to optimize the community's skills in processing these natural resources through the KKN program with the Desapreneur theme. The Desapreneur theme is raised to increase the knowledge and skills of the community in optimally processing natural resources. One of the programs this time is by utilizing melinjo and palm sugar as raw materials for making dodol which will later provide benefits by increasing the income of the people of Pusuk Lestari Village. The stages of the Dodol Melinjo Aren Making Training are preparation of tools and materials, outreach, training, packaging, marketing, and evaluation. The results of the implementation of this training activity are increasing the knowledge and skills of the community so that they are able to continue the Dodol Making Training program. Several additional programs were also carried out, namely making tourist maps, teaching at school and teaching the Koran, clean village activities (PABERSA), and English courses.
SOSIALISASI KEWIRAUSAHAAN DAN PELATIHAN PEMBUATAN KRIPIK TALAS DI DESA SELAT KECAMATAN NARMADA KABUPATEN LOMBOK BARAT
Authors: Mubarak Yazid Bustami Al , Alawiyah St. Safira , Reviana Isabela Putri , Safira Annisa Nanda , Nurwasilah Lisda , Maulida Nurul , Hotimah Husnul , Gomes Aprilia Nelina , Isnaini Lilis Nur , Dasilva Jennifer Isabelana
Published: May 2023

Community Service Program (KKN) has become part of educational activities as well as community service. The importance of this activity is to become a life lesson in the midst of the community in helping solve the problems faced by the community. Selat Village, Narmada District, West Lombok Regency has abundant potential for plants in the form of taro. The main problem in community service is the lack of potential agricultural products. When taro tubers are abundant, the market doesn't absorb the yield, so this taro has no selling value. This potential can be utilized by the community to increase the added value and selling value of these crops. For this reason, it is necessary to carry out training activities for processing taro tubers into products that are useful and have economic value so that they can increase the income of the people of Selat Village. The purpose of this community service is to provide knowledge to residents who participate in training activities so that they are able to produce or process taro tubers into taro chips that are in demand by consumers and are able to apply marketing in selling products. Service Implementation Method, carried out by counseling, demonstration and practice methods. The result of community service with the entrepreneurship outreach program and training in making taro chips in Selat Village is an increase in taro processing skills and it is hoped that the community will be able to open MSME businesses so that they can improve the community's economy.
PELATIHAN PEMBUATAN ABON IKAN DARI HASIL NELAYAN SEBAGAI INOVATIF GUNA MENINGKATKAN EKONOMI MASYARAKAT DESA SELENGEN KECAMATAN KAYANGAN
Authors: Firmansyah Firmansyah , Aini Rohmiatun , Yunia Indra , Chatami Lalu Radinal Ihya , Fitriani Baiq Annisa , Nisa Haerun , Supasta I Gede , Hartati Junia , Babgi Faiz Karim
Published: May 2023

Sea fish is one of the problems in the utilization of natural resource commodities in Selengen Village. In addition, the limited knowledge and skills of the community to innovate in fish processing, especially Layang fish, which is useful for improving the people's economy in Selengen Village. Processed fish will be made into a food product that can attract public interest. The overall form of activity includes: Socialization and training on the production of shredded fish from the type of Layang fish, Production of shredded Layang fish, Marketing of the shredded Layang fish production to the market. The Layang shredded fish production activity is a continuation of the program mentioned above. This program is carried out for the utilization of Layang fish to be processed into shredded Layang fish. It is hoped that by carrying out this marketing, PKK mothers can re-practice the results of the training that has been taught and prepare for independence to produce shredded fish on their own to add to the economy. It is hoped that in the future the women in Selegen village will know better how to make shredded meat with the right dosage, various flavors and attractive packaging. Because in Selengen village there are no MSMEs yet, it is suggested that the village can revive BUMDES and form MSMEs so that the potential in the village can be disseminated and can help the community's economy.
PUDING 4 BINTANG SEBAGAI ASUPAN GIZI UNTUK CEGAH STUNTING DI DESA SEMBALUN LAWANG
Authors: Dzulqaidah Intan , Sari Khopipah Wandan , Wardini Tira Ruhiana , Andrianu Ferdi , Alimajaya Ahda , Andriansyah Andriansyah , Multazam M. Jauhari , Aqila Qorina , Amalia Winda Rizki , Parwati Popy Yuli
Published: May 2023

Stunting is a chronic nutritional disorder that affects the growth and development of children. Stunting is still a problem that needs to be addressed in Sembalun Lawang Village. Prevention of stunting needs to be implemented to reduce the incidence of stunting in Sembalun Lawang Village. Stunting can be prevented through good nutrition for pregnant women and children in their toddler years. Pudding 4 stars is a form of processed healthy food that can meet nutritional intake for pregnant women and toddlers. The purpose of this activity is to increase the knowledge of mothers and expectant mothers regarding stunting, balanced nutrition, and healthy food processing. The method of implementing the activity is by conducting counseling related to stunting and balanced nutrition as well as demonstrations of making healthy food. The results of this activity increase the knowledge of mothers and prospective mothers regarding the dangers of stunting and how to prevent it, namely through the provision of good nutrition. Through this activity it is expected to be able to reduce the incidence of stunting in Sembalun Lawang Village.
PEMANFAATAN HIDROPONIK AJB SEBAGAI MEDIA BUDIDAYA TANAMAN SELADA (Lactuca sativa L) DI PEKARANGAN RUMAH
Authors: Aqhsal Muhammad
Published: May 2023

The AJB hydroponic system is a type of hydroponics found by managers from Mataram who use a substrate or planting medium in the form of sand. Hydroponics generally allows plant roots to sink in water or nutrient solution, but this can cause the roots of planted plants to decay because they are always in water. In the AJB hydroponic system, the roots of the lettuce plant will not be inundated directly because the water will mix with the sand substrate as the planting medium and the water itself will stagnate under the pot to the limit of the holes in the AJB hydroponic pot. The nutrients used in this system are a mixture of nutrients a and b or AB mix which is given through a pipe in the middle of the pot. This is so that the distribution of nutrients from the middle can be spread evenly. The pipe in the middle also has a hole at a height close to the surface of the soil so that the nutrients provided can reach and stimulate the roots to grow to the bottom where the nutrients are stagnant. In this study, the aspect observed was the growth in height of lettuce leaves/day which was calculated manually using a ruler by providing 1 liter of nutrients per each pot at the beginning and providing nutrients once every 3 days thereafter with a volume of 0.28 liters/each pot. The results of this study were an average growth of 0.286 cm/day for all samples or lettuce seedlings from pot 1 to pot 7.
MEMBANGUN KESADARAN MASYARAKAT MENGENAL KESEHATAN LINGKUNGAN MELALUI PEMANFAATAN LIMBAH PLASTIK MENJADI ECOBRICK DI DESA GUNUNG MALANG KECAMATAN PRINGGABAYA KABUPATEN LOMBOK TIMUR
Authors: Alfiqri Rizal  Fahmi , Anugrah Muhammad Ihsan , Fachri Zul , Akbar Jaelani Muhammad , Olivianti Anisa , Ramdani Nursuci , Hadiyawati Titin , Fitria Fitria , Oktaviana Nuriastika , Zannah Raodatul
Published: May 2023

The Real-Thematic Work Lecture activity was carried out in Gunung Malang Village, Pringgabaya District, East Lombok Regency which aims to introduce the public to environmental health through managing plastic waste to become ecobricks. This activity is carried out using the descriptive method, this method is more suitable for use because it describes problems that occur in the present or are ongoing. To introduce the community about ecobricks, socialization and training is carried out in each hamlet. Apart from wanting to be more involved with the community, it is hoped that any knowledge that is shared can be conveyed properly.
KKN TEMATIK UNRAM 2022 MELAKSANAKAN PEMBUATAN PESTISIDA ALAMI BERBAHAN DAUN PEPAYA DI DESA KARANG BAYAN
Authors: Yuniarto Kurniawan , Setiawan Aldi Januar , Alfianita Aulia , Ekaputri Baiq Mayzahra Aulia , Miqraj Gaosi Samdani , Sari Gita Sagita , Labysta Gyso Assykar , Pramesty Kinkin Ayu , Wulandari Ririn , Sudarmaji Sudarmaji , Saputri Yuni
Published: May 2023

The agricultural sector is the backbone of the community's economic activities in general. Not only as a source of food for the people every day, but as a source of foreign exchange for the country as well. Karang Bayan Village, which is located in Lingsar District, West Lombok Regency, is an example of a village with a community that until now still relies on the agricultural sector as a life support. This can be seen from the livelihoods of the people, most of whom work as farmers. The commodities planted by Karang Bayan Village farmers are rice, mangosteen, rambutan and durian. The cultivation of these plants does not always run smoothly, one of the factors is the presence of Plant Pest Organisms (OPT). One way to control pests is to use pesticides on plants. Pesticides consist of 2 types, namely chemical pesticides and natural or vegetable pesticides. One example of a plant that can be used as a pesticide is the papaya plant (Carica papaya). Given that papaya leaves are very easy to find and are not put to good use by the Karang Bayan community, the purpose of this service activity is to provide training and assistance in making natural papaya pesticides in Berembeng Timur Hamlet, Karang Bayan Village, Lingsar District, West Lombok Regency. Pesticide manufacturing activities This natural pesticide program starts on December 27, 2022 until January 24, 2023. This natural pesticide production and training activity aims to provide information and invite the public to be able to make their own natural pesticides so that they can be used to reduce the number of pests such as fleas on cultivated plants, especially in mangosteen plant.
PENGOLAHAN LIMBAH BIJI RAMBUTAN MENJADI EMPING TOLANG BULUAN DI DESA KARANG BAYAN KECAMATAN LINGSAR
Authors: Sari Nila , Melyana Melyana , Kalsum Umul , Ramdani Agus
Published: May 2023

So far, people consider rambutan seeds as unused waste, even though rambutan seeds have many health benefits. The purpose of the activities carried out by UNRAM Integrated KKN students is so that people can utilize rambutan seeds into products that have sales value. This activity was carried out in Karang Bayan Village, Lingsar District, West Nusa Tenggara. The approach used in this activity is Learning by Doing. UNRAM's integrated KKN student team learned by practicing directly how to process rambutan seeds with the tools and materials that had been prepared. This approach is expected to be more effective in achieving the output targets in KKN activities in Karang Bayan Village. The results of the implementation of the Integrated Community Service Program (KKN) activities are able to provide information and innovation about processing rambutan seed waste so that the community is able to process rambutan seed waste into a creative business venture, which is able to show creativity in turning unused waste into a valuable product. In addition, this activity can also be an option to reduce waste, especially rambutan seeds.
Como funciona o cérebro depressivo e quais são os seus sintomas
Authors:   , Siqueira Andrezza
Published: May 2023

O presente estudo tem como propósito elucidar que a depressão diferente do que pensa o senso comum, é uma doença grave com alterações químicas no cérebro do depressivo causando diversos sintomas como tristeza, anedonia, ausência de vitalidade e nos casos mais graves pode levar ao suicídio, mas o impacto da depressão na qualidade de vida vai muito além de tristeza ou desanimo, envolvendo sintomas físicos, e isso acontece por ser um transtorno mental que acomete alterações em nosso cérebro em níveis estruturais. Nesse ponto se percebe a importância de esclarecer alguns pontos que possam auxiliar no entendimento desta condição, mostrando de fato como esse transtorno funciona no organismo humano, trazendo para a cena uma nova visão do que é e do porque o indivíduo com depressão age da forma que age e sente as dores que sente, possibilitando o enfrentamento da depressão de forma responsável, visando o seu tratamento e a aceitação dessa condição como doença e não como uma simples tristeza.
Amazon Expedition Magazine (2)
Authors: Lima Newton Silva de , Castro Neto Alcides , Coimbra Alfredo Tadeu Oliveira , Ferreira Alan dos Santos , Oliveira Aldemir Malveira de , Willerding André Luiz , Silva Daniel Valentim Barros Mansur da , Ríos-Villamizar Eduardo Antonio , Façanha Filho Eriberto Barroso , Barbosa Evandro Brandão , Cáuper Fábio Raphael Moreira , Cidade Fernanda Cabral , Souza Guilherme Vilagelim de , Lima João Marcelo Silva , Lacerda Júnior José Cavalcante , Oliveira Josildo Severino de , Silva Karla Nunes da , Yamamoto Kedma Cristine , Tenório Kleitson José Lima , Oliveira Liliam Gleicy de Souza , Cáuper Luciana Lima de Brito , Pietzsch Madalena da Rocha , Escobar Maria Dóris , Jeffreys Manoel Feitosa , Souza Maryana Antônia Braga Batalha , Miranda Ordilena Ferreira , Reis Raquel Freitas , Monteiro Ricardo Figueiredo , Calazães Robson Matos , Félix Rodrigo de Oliveira , Vale Roseilson Souza do , Nascimento Thatyana de Souza Marques do
Published: May 2023

Edição de Setembro de 2023 (2o. ano) com trabalhos dos pesquisadores da Amazônia sobre Geociências e Humanidade
DIABETES MT1 AND MT2 CORRELATE DISEASES AND THEIR TREATMENTS
Authors: Grunbaum Dr. Sergio
Published: May 2023

ABSTRACT Diabetes Mellitus (DM) is a chronic disease that is associated with high morbidity and mortality rates, especially concerning its acute and chronic complications and is characterized by an increase in the concentration of glucose in the bloodstream due to a deficiency of insulin secretion or action. High drug costs, increased hospitalizations, increased number of medical appointments, lost productivity, and premature deaths are associated with diabetic patients. DM is a disease that must be treated correctly so that its complications are avoided and that there is no loss of quality of life for the patient.
Effect of duration of diabetic in glutamic acid decarboxylase autoantibodies and HbA1c in children with T1DM
Authors: Rahab A. Al-Madany  , Haider H. Mohammed Ali  , Kawkab A. Al Saadi
Published: May 2023

Background: a metabolic condition characterized by a failure in the metabolism of proteins, lipids, and carbohydrates that is brought on by problems with insulin production. When multiple autoantibodies, such as those against glutamic acid decarboxylase, are present against different insulin antigens, type 1 diabetes is present. Objective: To estimate the Glutamic Acid Decarboxylase Autoantibodies and assessment of HbA1c in type 1 DM. Methods: 40 children with diabetes participated, while 10 kids in the control group had blood sugar levels that were normal. HbA1c levels for each participant are measured as part of a quantitative ELISA test for the identification of circulating autoantibodies against glutamic acid decarboxylase in human serum. Results: All the pathological samples showed an increase in the concentration of Anti-GAD compared to the control. Samples of patients with diabetes for 5 years or more showed a decrease in Anti-GAD concentration compared to patients with diabetes for less than five years, but the decrease was not significant Conclusion: There was positive association between duration of type 1 Diabetes Mellitus and Glutamic Acid Decarboxylase Autoantibodies
Epidemiological and clinical aspects of chronic infections of hepatitis b virus at the Mohammed V military teaching hospital in Rabat – Morocco
Authors: Abdelkrim ELHOUSNI  , Bouchra CHAOUI  , Safae ELKOCHRI  , Rachid ABI  , Hicham ELANNAZ  , Idriss LAHLOU AMINE  , Khalid ENNIBI  , Mohamed Rida TAGAJDID
Published: May 2023

Background: Infection with hepatitis B virus is a major public health problem worldwide. Globally hepatitis B virus’s prevalence is 5.4%, more than one million between them die each year from complications that are essentially cirrhosis and hepatocellular carcinoma. The objective of this study is to describe epidemiological and clinical aspects of patients with chronic viral hepatitis B monitored in the Military Teaching Hospital Mohammed V in Rabat. Patients and methods: This are a retro-prospective study carried out in the virology laboratory of the Mohammed V Military Teaching Hospital in Rabat, spread over a period of 15 years from January 2001 to January 2016. Were included in our study all Moroccan patients aged 18 years and over with chronic viral hepatitis B defined by the presence of HBsAg beyond 6 months and the absence of IgM anti-HBc antibodies. Results and discussion: Out of 104 infected persons, 71% are men and 50% of infected was discovered by screening, 19% of patients had fatigue as a primary symptom, 69% had dental care as a risk factor and 46% of patients were carriers of the active form of chronic hepatitis B. Currently, few studies relate the epidemiology of HBV in Morocco. The prevalence of HBsAg during the study period was 1.03, despite this, Morocco is so far considered, according to WHO's data, as having an intermediate prevalence of viral hepatitis B. Conclusion: Immunization, compliance with universal recommendations for the use of medical and paramedical equipment as well as education and awareness are the only guarantee to limit the spread of Hepatitis B virus.
Bilingual and Non-Bilingual Classes at Primary School in Italy
Results from a Standardised National Test
Authors: Costa Francesca , Mariotti Cristina
Published: May 2023

This study aims at determining the effectiveness of the Bilingual Education Italy (BEI) project as opposed to monolingual programmes in primary education in Italy, a country with low exposure to English as a foreign language. The BEI project originated from a memorandum of understanding between the Directorate-General for Educational Systems and School Autonomy of the Ministry of Education, the Ministry for Universities and Research, and the British Council. The research questions focus on the difference in the performance in English, oral mathematics and oral Italian between BEI and non-BEI students. To answer them, a statistical analysis of the English language competence state test in two primary schools involved in the BEI project was carried out. A descriptive analysis of the scores obtained by BEI and non-BEI students was performed, followed by the analysis of the correlation between the scores in English, Italian and mathematics, and a linear regression considering all the relevant variables. The results point to an advantage of BEI students over non-BEI ones.
Determination of protein levels and amıno acid composition of bee pollen collected from different geographical regions of Turkey
Authors: TÜRE Aysel , NİSBET Cevat , KOÇAK Esra
Published: May 2023

In this study, determination of the amino acid profile of bee pollen produced in different parts of Turkey and performed to determine the protein level. The research was carried out with a total of 90 specimens from East-Southeast Anatolia, Central Anatolia, Black Sea, Marmara, Aegean and Mediterranean. According to the analysis results, alanine (143,40 ± 0,0) in bee pollen on mg / g basis, arginine (34,45 ± 0.0), histidine (32,55 ± 0.09), isoleucine (20,94 ± 1,24), leucine (23, 75 ± 1.27), lysine (31.15 ± 0.43), methionine (39.10 ± 1.32), phenylalanine (20.09 ± 0.95), proline (309.05 ± 28.56) and valine (15.79 ± 0.88) amino acids were detected. According to the analysis results, protein level of bee pollen in mg / g basis in Black Sea region (127,27 ± 0.31), Marmara region (117,56 ± 0.31), Mediterranean region (115,66 ± 0.31), Central Anatolia (115,09 ± 0.31), Aegean region (110,06 ± 0.31) and East-South East Anatolia (124,9 ± 0.31). The differences between the regions were found in Protein and amino acid levels (P
Usage areas of nanoparticles in veterinary dermatology
Authors: İLHAN Gökçe , DOKUZEYLÜL Banu , KAYAR Abdullah , OR Erman
Published: May 2023

Elements such as gold and silver have been used to treat various diseases since ancient times. These elements, which are used today, have been diversified and sized with many researches. Recently, it is seen that nanoparticles are frequently used in the medical field. Nanoparticles can be 1-1000 nanometers in size and gain biological, physical and chemical functionality due to their nano size. The type and size of these nanoparticles are chosen according to the area in which they will be used. These prepared drugs are used for purposes such as biosensor imaging, transporting drugs to the target organ, protecting the transported substance against denaturations, increasing the immunological response, and transporting chemotherapeutic drugs.

Today, with the increase in the number of dermatological cases in clinics, different treatment methods and systems are being developed. There are various nanoparticles used in dermatological cases to increase the bioavailability of topical, oral or injectable drugs and to increase the effect in the targeted area. These drugs have been used in conditions such as antimicrobial, antiparasitic, antifungal, allergen-specific immunotherapy, wound healing, tumors and atopic dermatitis. Many studies have also been carried out in the field of dermatology and it has been shown that nanoparticles used for follicular application provide advantages in dermal drug delivery, including improved skin bioavailability, increased depth of penetration, prolonged residence time, rapid transport to the skin and tissue targeting, in dermal drug delivery by using the appropriate nanoparticles in the right sizes. Particles can collect in the follicular opening and penetrate through the follicular canal when applied to the skin surface. This review has been prepared to investigate the usability of nanoparticle-derived drugs used in human medicine in veterinary applications.
Investigation of the effect of water temperature on water consumption of cats
Authors: TATLIAĞIZ Zeynep , AKYAZI İbrahim
Published: May 2023

Cats can naturally obtain their water requirements on the water content of their food. The wild cats usually do not need to drink water, because their prey (e.g., birds, small rodents, insects) contains about 70-75% body water. The same situation is applied for domestic cats too, which eat canned wet food that contains high level of water. However, if the water level of the diet is less than 60%, cats need additional drinking water. A mature cat must consume 60ml/kg/day water to maintain its body functions without any problem. Otherwise cats will be easily dehydrated and chronic dehydration can lead some health problems such as bladder and renal diseases and circulatory problems. Any practical method that could increase cats water consumption, would have a reducing effect on the before mentioned diseases.

Regarding the water consumption, the taste of water has been found as effective as the other physiological stimulants such as mouth dryness, plasma osmolality and blood volume. Temperature is considered to be very important for the taste perception of animals. The preference for the water temperature varies among the animal species.

So we hypothesized that, cooling the drinking water can encourage cats to drink more water and we aimed to investigate the effect of the water temperature on water consumption of cats.

This research has conducted with 8 domestic, mature and healthy pet cats (Felis domesticus) that live indoor. We measured the water consumption of cats for two weeks. During the first week, temperature of water has not been intervened, and the cats' normal water consumption were measured. On the 1st day, 500 ml water, measured with graduated cylinder, was provided in a standard water bowl. After 24 hours, the remained water has been measured and noted. After each measurement, cat owners refreshed the drinking water. In the 2nd week, we started to add four ice cubes to the water bowl, three times in a day. First week, cat’s average normal water consumption has found 142,26±8,09 ml/kg/day. (p
Household Industry Development through the Concept of Creative Economy (Case Study of Kripsus Industry in Sidowungu Village, Gresik)
Authors: Rahmadana Safira Putri
Published: May 2023

This research was made to find out how much development the household industry is through the concept of creative economy, especially in one of the local potentials of the region, namely, chicken intestines that are processed into chicken intestine chips. Creative industries based on local economic development can be a great prospect to encourage the emergence of new economic innovations that can empower local workers and ultimately advance the economy of Sidowungu Village. This research uses analytical methods and qualitative descriptive data, where this method is used to explain a phenomenon that is happening. The results showed that the concept of creative economy has an urgency that is quite influential on the development of the household industry.

Keywords: creative economy, home industry.