bluuebunny/crossref_metadata_2025 huggingface dataset:
Integration of Infomedia Literacy in the Process of Teaching Ukrainian Literature in Grades 5-6 of the New Ukrainian School
Authors:   Zaporizhzhia National University, Slyzhuk Olesya
Published: July 2022

The article reveals the basic principles and ways of forming information and media literacy of students during the study of Ukrainian literature in the adaptive cycle of basic secondary education. The analysis of methodical materials and scientific literature on the experience of introducing info media literacy in the educational process is carried out. The methods of integration of literary texts and other types of media texts in the process of studying Ukrainian literature are generalized and substantiated. It was found that the use of modern technologies for the development of critical thinking, the use of different types of media texts contribute to the formation of students in grades 5-6 reading competence, develop skills in working with information obtained from works of art. Areas of integration of information literacy in the process of teaching Ukrainian literature are the development of exercises to develop critical and analytical thinking of younger teenagers and attracting a broad artistic context, the availability of which allows the use of different types of media resources. The most important role in the process of teaching Ukrainian literature, taking into account modern educational trends and the requirements of an informative society, is played by a teacher of Ukrainian language and literature prepared for the current challenges. As a result of such a system of work – students of 5-6 grades consciously perceive and analyse literary works, understand their relevance, relate to the general cultural context, can identify facts of reality reflected in the works and the writer's judgments about them.
The Influence of Interpersonal Relations on the Formation of Intercultural Competence of Future Specialists of Socionomic Professions
Authors:   Ternopil Volodymyr Hnatiuk National Pedagogical University, Pryshlyak Oksana , Drapak Halyna ,   Ternopil Volodymyr Hnatiuk National Pedagogical University
Published: July 2022

The article provides a theoretical analysis of the problem of interpersonal relationships and interactions, which are considered in the context of the study as factors influencing the process of formation of intercultural competence of future professionals of socionomic professions. The authors conclude that the effectiveness of intercultural education directly depends not only on the formalized methods and tools used in the educational process in higher education, but also on psychological factors, motivation and encouragement, activity and belief of students in the need for intercultural competence and the formation of intercultural competence as important components of future professional activity, as well as the psychological components that accompany the implementation of the system of formation of intercultural competence, in particular such as interpersonal relationships and interactions; psychological climate, psychological atmosphere, general emotional state of future specialists of socionomic professions. Complementing the content of intercultural education with subjective interpersonal relationships between teachers and students, as well as with representatives of different ethnocultural communities and groups, allows us to characterize them as important factors in the process of forming intercultural competencies. Psychological attitude to intercultural education determines the motivation and activity of students, which involves internal approval of the need for this education, the formation of attitudes towards it as a professional necessity. Accordingly, learning activity is manifested in the form of psychological involvement in the process of intercultural education.
Mediation as a Social Technology in the Work of a Social Worker: Principles of Implementation and Technological Conditions
Authors:   Khmelnytsky National University, Holova Nataliia
Published: July 2022

The article considers the model of mediation as a way of resolving conflict situations, as well as approaches to building the structure of mediation and mediation processes. The essence of mediation as an alternative way of resolving conflict situations is revealed. The methodological principles of mediation regulation and their implementation in the period of transitive development of society are analyzed; its advantages in comparison with the court process are characterized. It is determined that mediation is the driving force aimed at resolving conflict issues, which satisfies the interests of both parties. The role of a social worker in the mediation process and the conditions and procedure for its implementation are substantiated. It was found that mediation is not possible without psychological principles of social work, which include the principles of congruence, impartiality, confidentiality, positive activity. Reasoned stages of mediation, which can be divided into two main groups: the work that a social worker does before the meeting of the conflicting parties, and the actions he performs during formal negotiations, and the fact that mediation as a social technology can really ensure neutrality under certain conditions, which must be observed and fulfilled by a social specialist.
The Results of the Study «Attitude of Parents to the Problem of Toys in a Child's Life: Socio-Pedagogical Aspect»: to the Problem of Responsible Parenting
Authors:   Khmelnytsky National University, Danylchuk Larysa
Published: July 2022

The article presents the results of the study «Attitude of parents to the problem of toys in a child's life: socio-pedagogical aspect». It is noted that toys play a significant role in the upbringing, development, socialization of the child. At that time, the responsibility for choosing/purchasing toys remains with adults. The study was conducted in November-December 2021 in Khmelnitsky and Zhytomyr regions among men and women aged 20 years and older with at least one child. The results obtained made it possible to state a number of issues in the stated problems: parents do not always understand educational, didactic, etc. importance of toys in a child's life. Toys for children are bought mainly by women; men, in a certain way, are removed from this issue; also because many women are forced to raise children without men. Among the selected clusters of toys, toys-characters and toys-replicas of real objects are more often bought, compared with toys-space markers and educational toys. A significant number of participants confirmed that regardless of the age of the children, they use gadgets (mobile phones) as toys. Parents do not always realize the degree of their responsibility for the safety of children online and in social space, which have modern gadgets as toys. Among the participants in the experiment, there are many men and women who do not distinguish/identify the concepts of «toy», «games», «game activity». In the context of responsible fatherhood, we also consider the fact that a quarter of the women and men surveyed showed that instead of toys they read books with their children and watch cartoons/movies as positive results in the context of responsible fatherhood.
Online Services and Data Processing Software for Pedagogical and Social Research
Authors:   State Institution Luhansk Taras Shevchenko National University, Stepanenko Viktoriia , Stepanenko Viacheslav ,   State Institution Luhansk Taras Shevchenko National University
Published: July 2022

In the presented article, an attempt was made to present a conditional set of services and programs that allow the collection, systematization, statistical processing of data and presentation of results, including visualization (graphs, tables of results, charts, etc.). It is noted that the main trend in the development of modern services is their complexity. As a rule, several operations can be performed using one service (data collection, their primary mathematical processing, visualization, etc.). Therefore, all classifications of such services are rather conditional. A review of certain online services and software packages for capturing, processing and storing data from pedagogical and social research was carried out: Google Sheets, Google Forms, Microsoft Office Excel, STATISTICA, SPSS, online calculators, etc. The advantages and disadvantages of using these services are outlined. It is noted that the use of ICT in pedagogical and social research improves their quality and compliance with modern requirements for the processing of experimental data.
Bio-Medical Image Segmentation using Wavelet Based Fusion Technique
Authors: H N Swaroopa , Jagadale Basavaraj N , B S Priya , Alnaggar Omar Abdullah Murshed Farhan , T E Abhisheka
Published: July 2022

In recent years, bio-medical image segmentation is established itself as base for image analysis. This article proposes a new method in developing a robust wavelet based medical image fusion technique for image segmentation. A GLCM (Gray Level Co-occurrence Matrix) based statistical method is used to extracts the texture features of the image decomposed at single level and the image is segmented based on region growing method. The combination of these two along with fusion technique gives a new segmented image. The results indicate the efficiency of the proposed method in segmenting the both normal cell images as well as darker cell images.
Nanocarriers: The Promising Future to Cancer Diagnostics and Treatment
Authors: K. Tapasya K. Tapasya , Kumar Ashmitha Suresh , Dharmarajan Arunasalam , Parvathi Venkatachalam Deepa
Published: July 2022

Nanotechnology recently gained attention for the novel and successful tools it has thus far provided for cancer diagnosis and treatment. Some of them include lipid-based carriers such as liposomes and metal-based particles such as nanoshells (NSs), used for anti-cancer drug delivery for the most part. Each one of these systems has been carefully designed in order to bypass the obstacles brought forward by conventional diagnosis and treatment strategies. These challenges include non-specificity, premature drug release and toxicity. From research conducted over the years it is clear that nanocarriers ameliorate bioavailability, specificity and accumulation of the drugs at the target site. These improvements can be explained by their easily adjustable physical and chemical properties. Alterations to their size and surface structure are often made to enhance their accumulation at the target sites and overall targeting capabilities respectively. Some nanocarriers such as quantum dots (QDs) and carbon nanotubes (CNTs) display excellent fluorescent properties and are useful candidates for imaging techniques and fluorescence-guided surgery. Another group of promising nanoparticles is biomimetic nanoparticles that mimic the functionality of biological components. These NPs are designed to mimic basic cellular and physical features of the source cells and their surface. This type of NPs construct is exploited for its unique characteristics that aid in effective interaction with complex biological systems, consequently enhancing therapeutic outcomes After establishing them as adequate tools for drug delivery and imaging, nanocarriers are now being tested in combined cancer treatment strategies. This review provides an understanding of the salient nano-devices and their applications in oncology.
The Prevalence and the Patterns of the Expression of Latent Epstein-Barr Virus in Hodgkin’s and Non-Hodgkin’s Lymphomas Among Patients in Oman: Immunohistochemistry Versus in Situ Hybridization.
Authors: Al-Mamari Muzna Said Rashed , Al-Sinawi Shadia , AL-Rahbi Fathiya Salim , Mabruk Mohamed
Published: July 2022

Epstein Barr virus (EBV) has been incriminated in the pathogenesis of Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). The present study aimed to investigate the prevalence and the pattern of the expression of Epstein-Barr in HL and NHL tissue samples obtained from Omani patients attending Sultan Qaboos University Hospital (SQUH). Besides, to compare the sensitivity and specificity of immunohistochemistry(IHC) and in situ hybridization (ISH) for the detection of EBV in HL and NHL and finally to have more understanding of the pathogenesis of EBV in HL and NHL among patients in Oman. Formalin-fixed paraffin-embedded tissue samples consisting of 26 Hodgkin and 34 non-Hodgkin lymphomas were assessed for the presence of EBV by IHC to detect Latent membrane protein (LMP), expression and by using ISH to detect Epstein -Barr encoded RNAs (EBERs). The expression of LMP and EBERs were detected respectively in 46.2% and 57.7% of Hodgkin’s lymphoma cases and were detected in 11.8% and 14.7% respectively of non-Hodgkin’s lymphoma cases. The intensity of LMP-1 and EBER expression was significantly high in mixed cellularity compared to other subtypes. The expression of EBV was detected in transformed cells in both HL & NHL. The expression of EBV in transformed cells in both HL and NHL indicates that EBV may play a pro vital role in the pathogenesis of HL and NHL among patients in Oman. Moreover, this study indicates that IHC is to some degree compatible in terms of sensitivity and specificity to ISH in the detection of EBV in HL and NHL.
Thrombolytic Property of Herbal Plants: A Short Review
Authors: Guguloth Sarvan Kumar , Malothu Narender , Kadiri Sunil Kumar , Kunuru Sowjanya
Published: July 2022

Since, ancient time medicinal plants have been using to treat various human ailments. Blood clotting causes various heart associated diseases like myocardial infarction, deep vein thrombosis and renal vein thrombosis. Thrombolytic drugs are being employed to lyse the thrombus (blood clot) formed in the arteries. The modern systems of medicines have certain limitations and serious consequences which can alter the normal hemostasis process. Herbal medicines are known for their safety and efficacy in treating diseases effectively without producing any untoward effects. The present review provides the medicinal importance of some plants as thrombolytic agents. The source for the present review was taken from literature survey carried through the findings from suitable keywords in databases, PubMed, Google Scholar and Web of Science and Scopus, etc. This review provides the detailed information on medicinal plants and phytochemical compounds as thrombolytic agents.
Melittin-Induced Cell Death Through p53 and 8-OHdG in Breast Cell Cancer MCF-7
Authors: Plasay Makkasau , Natzir Rosdiana , Cangara Muhammad Husni , Hardjo Marhaen , Syahrijuita Syahrijuita , Soraya Gita Vita
Published: July 2022

Melittin, one of the cytolytic peptides derived from bee venom, is a broad-spectrum efficacy candidate as an antibacterial, antifungal, and antitumor agent. This study demonstrates the cytotoxic effect of melittin isolated from Apis mellifera through the induction of p53 and 8-OHdG. The antiproliferative effect was evaluated against breast cell cancer MCF-7 via MTT assay, while the molecular mechanism of melittin on MCF-7 was assayed by p53 and 8-OHdG ELISA. With an IC50 value of 5.86 µg/mL ((very toxic)), the cytotoxic impact inhibits MCF-7 cell proliferation in a dose-dependent manner. Significant (p < 0.05) elevations in the level of p53 and 8-OHdG were evident in the IC50-treated cells compared to control. In conclusion, melittin may have considerable potential as a novel natural product-based for breast cancer.
Jorge Jiménez López, Libros y primer humanismo en Salamanca. Inventarios y ámbitos del patrimonio librario del Colegio Mayor de San Bartolomé de la Universidad de Salamanca entre 1433 y 1440, Salamanca, Ediciones Universidad de Salamanca, 2020
Authors: Casas Hernández Mariano
Published: July 2022

Reseña del libro: Jorge Jiménez López, Libros y primer humanismo en Salamanca. Inventarios y ámbitos del patrimonio librario del Colegio Mayor de San Bartolomé de la Universidad de Salamanca entre 1433 y 1440, Salamanca, Ediciones Universidad de Salamanca, 2020.
Estimation precision for a normalized response matrix in linear polarization calibration
Authors: Li Xinkai , Miao Pengfei , He Lingping , Shen Heng , Wang Xiaodong , Gong Bowen , Gao Xingjun , Chen Bo
Published: July 2022

The purpose of polarization calibration is to obtain the response matrix of an instrument such that the subsequent observation data can be corrected. The calibration precision, however, is partially restricted by the noise of the detector. We investigate the precision of the normalized response matrix in the presence of signal-independent additive noise or signal-dependent Poisson shot noise. The influences of the source intensity, type of noise, and calibration configuration on the precision are analyzed. We compare the theoretical model and the experimental measurements of the polarization calibration to show that the relative difference between the two is less than 16%. From this result, we can use the model to determine the minimum source intensity and choose the optimal configurations that provide the required precision.
Design of compact dual-mode photoelectric modulator with high process tolerance based on vanadium dioxide
Authors: Zhan Qipeng , Pang Haibin , Liao Junneng , Luo Wenlai , Wang Gang , Ren Xingang , Wang Jun , Duan Zongming , Huang Zhixiang , Ding Li
Published: July 2022

Opto-electro modulators with nanometer-scale footprint are indispensable in integrated photonic electronic circuits. Due to weak light–matter interactions and limits of micro–nano fabrication technology, it is challenging to shrink a modulator to subwavelength size. In recent years, hybrid modulators based on surface plasmons have been proposed to solve this problem. Although the introduced high lossy surface plasmons provide large modulation depth, the polarization selectivity limits its application. Toward this end, in this paper, we present a design of an ultra-compact vanadium oxide (

V
O

2

)-based plasmonic waveguide modulator for both transverse electric (TE) and transverse magnetic (TM) modes. The device consists of two silicon tapers and a silicon waveguide embedded with a

V
O

2

wedge. When electrical signals put on the device change the phase of 

V
O

2

from a metal to an insulator, the output optical signals along the waveguide are significantly modulated. For a 1.5 µm length modulator operating at 1.55 µm wavelength, the extinction ratio is 11.62 dB for the TE mode and 8.86 dB for the TM mode, while the insertion loss is 4.31 dB for the TE mode and 4.12 dB for the TM mode. Furthermore, the proposed design has excellent tolerance for fabrication process error, which greatly increases the yield rate of products and indicates a promotable application prospect.
Depth-resolved extraction of optical attenuation for glaucoma assessment in clinical settings: a pilot study
Authors: Chang Shuang , Murff Clara , Leng Theodore , Groth Sylvia L. , Bowden Audrey K.
Published: July 2022

We assessed the ability of the optical attenuation coefficient (AC) to detect early-stage glaucoma with two AC estimation algorithms: retinal layer intensity ratio (LIR) and depth-resolved confocal (DRC). We also introduced new depth-dependent AC parameters for retinal nerve fiber layer assessment. Optical coherence tomography B-scans were collected from 44 eyes of age-similar participants with eye health ranging from healthy to severe glaucoma, including glaucoma suspect patients. Mean AC values estimated from the DRC method are comparable to ratio-extracted values (p > 0.5 for all study groups), and the depth-dependent ACDRC parameters enhance the utility of the AC for detection of early-stage glaucoma.
LuckyProfiler: an ImageJ plug-in capable of quantifying FWHM resolution easily and effectively for super-resolution images
Authors: Li Mengting , Song Qihang , Xiao Yinghao , Wu Junnan , Kuang Weibing , Zhang Yingjun , Huang Zhen-Li
Published: July 2022

Quantifying the resolution of a super-resolution image is vital for biologists trying to apply super-resolution microscopy in various research fields. Among the reported image resolution estimation methods, the one that calculates the full width at half maximum (FWHM) of line profile, called FWHM resolution, continues the traditional resolution criteria and has been popularly used by many researchers. However, quantifying the FWHM resolution of a super-resolution image is a time-consuming, labor-intensive, and error-prone process because this method typically involves a manual and careful selection of one or several of the smallest structures. In this paper, we investigate the influencing factors in FWHM resolution quantification systematically and present an ImageJ plug-in called LuckyProfiler for biologists so that they can have an easy and effective way of quantifying the FWHM resolution of super-resolution images.
Optical glass and optical design: Otto Schott´s role in the entangled development
Authors: Fotheringham Ulrich , Petzold Uwe , Ritter Simone , James William
Published: July 2022

Meeting the stringent requirements of optical design has been the task of material developers for centuries. Preventing simple solutions, however, are the fundamental limitations to the performance of optical materials following the Kramers-Kronig-relations of solid state physics. To achieve optimum optical performance, an entanglement between optical designers and material developers has occurred. This entanglement has led to suitable multi-lens designs that push optical materials to their limits. Herein is a contribution that reviews pioneering work in optical material development, the role of Otto Schott and the intricate entanglement of optical design and optical materials.
Optical properties of CsFAMA-based perovskite film and its application in the inverted solar cells with poly(methyl methacrylate) passivation layer
Authors: Feng Yanqin , Zhang Yuman , Duan Chengyi , Zhao Minglin , Dai Jun
Published: July 2022

We reported the basic optical properties of a triple cation CsFAMA perovskite film and its application in the inverted p-i-n solar cells. The exciton binding energy of 42 meV and the refractive index of 2.4 is obtained from the temperature-dependent photoluminescence spectra and spectroscopic ellipsometry measurement, respectively. The results indicate that CsFAMA lead halide perovskite is an excellent light-absorbing material. The inverted p-i-n CsFAMA perovskite solar cells with PMMA passivation layer are studied, and the optimized PCE can be increased to 16.90% with a negligible hysteresis effect. The long-term and thermal stabilities of CsFAMA perovskite solar cells can be improved after PMMA passivation, which maintains 81% (40% relative humidity, 25 °C, 720 h) and 91% (50% relative humidity, 100 °C, 6 h) of initial efficiencies, respectively. This work provides a promising method for stable and low-cost inverted perovskite solar cells.
C and L band fiber lasers enhanced by ultrafast laser inscribed artificial backscatter reflectors
Authors: Perez-Herrera Rosa Ana , Roldan-Varona P. , Sanchez-Gonzalez A. , Cobo L. Rodriguez , Lopez-Higuera J. M. , Lopez-Amo M.
Published: July 2022

This letter presents an experimental comparison between two linear-cavity erbium-doped fiber lasers (EDFL) assisted by two different artificial backscatter fiber-based reflectors. Both reflectors were inscribed by femtosecond laser direct writing, one of them within a single-mode fiber (SMF) and the other one within a multi-mode fiber (MMF). Although the erbium-doped fiber amplifier (EDFA) used in both structures was the same and both reflectors were manufactured under the same parameters, the reflection spectrum of each was clearly different due to their different physical properties. The first linear-cavity EDFL, consisting of an SMF-based reflector with 9µm core and 125µm cladding, resulted in a single laser emission line located in the C-band and centered at 1564.4 nm, exhibiting an optical signal-to-noise ratio (OSNR) of 52dB when pumped at 100mW. On the other hand, a single laser emission line with a similar OSNR but in L-band (centered at 1574.5nm) was obtained when using an MMF-based reflector with 50µm core and 125µm cladding.
Age and information preference: Neutral information sources in decision contexts
Authors: Rutt Joshua L. , Isaacowitz Derek M. , Freund Alexandra M.
Published: July 2022

Do adults of different ages differ in their focus on positive, negative, or neutral information when making decisions? Some research suggests an increasing preference for attending to and remembering positive over negative information with advancing age (i.e., an age-related positivity effect). However, these prior studies have largely neglected the potential role of neutral information. The current set of three studies used a multimethod approach, including self-reports (Study 1), eye tracking and choice among faces reflecting negative, neutral, or positive health-related (Study 2) and leisure-related information (Study 3). Gaze results from Studies 2 and 3 as well as self-reports from Study 1 showed a stronger preference for sources of neutral than for positive or negative information regardless of age. Findings also suggest a general preference for decision-relevant information from neutral compared to positive or negative sources. Focusing exclusively on the difference between positive (happy) and negative (angry) faces, results are in line with the age-related positivity effect (i.e., the difference in gaze duration between happy and angry faces was significantly larger for older than for younger adults). These findings underscore the importance of neutral information across age groups. Thus, most research on the positivity effect may be biased in that it does not consider the strong preference for neutral over positive information.
Diversity in HIV epidemic transitions in India: An application of HIV epidemiological metrices and benchmarks
Authors: Kumar Pradeep , Das Chinmoyee , Kumar Arvind , Sahu Damodar , Rai Sanjay K. , Godbole Sheela , Arumugam Elangovan , P. V. M. Lakshmi , Dutta Shanta , Devi H. Sanayaima , Vardhana Rao Mendu Vishnu , Kant Shashi , Pandey Arvind , Reddy Dandu Chandra Sekhar , Mehendale Sanjay , Rajan Shobini
Published: July 2022

Background

The Joint United Nations Programme on AIDS (UNAIDS) has emphasized on the incidence-prevalence ratio (IPR) and incidence-mortality ratio (IMR) to measure the progress in HIV epidemic control. In this paper, we describe the status of epidemic control in India and in various states in terms of UNAIDS’s recommended metrices.

Method

The National AIDS Control Programme (NACP) of India spearheads work on mathematical modelling to estimate HIV burden based on periodically conducted sentinel surveillance for providing guidance to program implementation and policymaking. Using the results of the latest round of HIV Estimations in 2019, IPR and IMR were calculated.

Results

National level IPR was 0.029 [0.022–0.037] in 2019 and ranged from 0.01 to 0.15 in various States and Union Territories (UTs). Corresponding Incidence-Mortality Ratio was at 0.881 [0.754–1.014] nationally and ranged between 0.20 and 12.90 across the States/UTs.

Conclusions

Based on UNAIDS recommended indicators for HIV epidemic control, namely IPR and IMR; national AIDS response in India appears on track. However, the program success is not uniform and significant heterogeneity as well as expanding epidemic was observed at the level of States or UTs. Reinforcing States/UTs specific and focused HIV prevention, testing and treatment initiatives may help in the attainment of 2030 Sustainable Development Goals of ending AIDS as a public health threat by 2030.
Un estudio exploratorio sobre los presupuestos participativos infantiles en el ámbito español
Authors: Pardo Beneyto Gonzalo , Abellán López María Ángeles
Published: July 2022

Esta nota metodológica adelanta datos valiosos sobre una investigación en curso, cuyo objetivo fundamental es comprobar la validez de una serie de variables que sirvan para el estudio del fenómeno de presupuestos participativos infantiles en España durante un periodo comprendido entre el 2015 y el 2021. Al igual que ocurre con esta experiencia participativa en el ámbito adulto, su definición es complicada dada la adaptación de la metodología al entorno en el que se implementa. Para su conformación, se han realizado encuestas de pregunta abierta (35 respuestas válidas) que han sido estudiadas a través de un análisis de datos cualitativos y el uso del programa MAXQDA. La realización de este estudio se ha llevado a cabo a partir del estudio de las siguientes variables: 1) las características de los participantes, 2) el análisis del lenguaje utilizado en las encuestas, 3) el desarrollo de los instrumentos utilizados y, 4) la finalidad de las experiencias. Dada la importancia de estas variables se aportan una serie de hallazgos provisionales. Entre estos se puede hacer referencia a la proliferación de experiencias con múltiples participaciones y el desarrollo medio de las experiencias analizadas. Además, hay que mencionar que existe un sesgo hacia los instrumentos que fomentan exclusivamente la participación por encima de otros valores.
La dimensión de género en las poéticas visuales contemporáneas sobre los desplazamientos forzados: el caso de Centroamérica
Authors: Gas Barrachina Silvia
Published: July 2022

Los desplazamientos forzados en Centroamérica, causados especialmente por la violencia que domina el territorio, responden a un movimiento migratorio en el cual las mujeres, por su condición de género, resultan más vulnerables. La violencia de género es una de las causas principales de migración y una constante que sufren las mujeres durante todo el trayecto. El arte constituye una herramienta de reflexión y visibilización de aspectos de la realidad próximos a las artistas. Por ello, analizar el proceso migratorio desde el ámbito artístico posibilita comprender el fenómeno estudiado desde otras perspectivas, aportando nuevos conocimientos. En este sentido, las obras de arte, cuyas narrativas presentan las múltiples experiencias del desplazamiento, generan diversas estéticas influenciadas por la confluencia de expresiones culturales que desarticulan las representaciones normativas, actuando sobre la percepción de quien observa. Partiendo de este contexto, el objetivo principal de esta investigación residió en analizar las prácticas de artistas centroamericanas cuyas narrativas se fundamentan en representar dicho fenómeno. Para tal fin, se empleó una metodología fundamentada en la crítica de arte feminista que pusiera en valor las experiencias de las mujeres, como sujetos creadores, quienes desde su propia mirada presentan narrativas y estrategias que renuevan conceptos estéticos hegemónicos. Asimismo, se emplearon métodos propios del ámbito del arte para analizar las producciones artísticas. Los principales resultados obtenidos posibilitan radiografiar cada periodo del proceso migratorio en el cual la categoría mujer es representada según parámetros propios de la cultura identitaria centroamericana, sin centrarse exclusivamente en la violencia que sufren las mujeres en los desplazamientos forzados.
Crianzas medicalizadas y tecnologías psicosociales para el gobierno de la infancia: cuando las madres cuentan
Authors: Hurtado-García Inma
Published: July 2022

La crianza es un ámbito creciente de experticia en la que el discurso profesional viene organizando el conocimiento sobre la infancia y sus requerimientos solapando, a su vez, el conocimiento lego, corrigiéndolo, reformulándolo o ampliándolo con nuevos aspectos no contemplados. La crianza se convierte así en una suerte de «tecnología del tú», un saber que no solo implica conocer el desarrollo y necesidades de hijas e hijos, sino también ser capaz de modificar ciertas características a través del entrenamiento de habilidades y actitudes. El presente artículo plantea como objetivo el análisis de las implicaciones que la crianza contemporánea guiada por profesionales tiene en el caso del Trastorno de Déficit de Atención e Hiperactividad (TDAH) infantil. La metodología empleada ha sido el trabajo de campo realizado a lo largo de los dos periodos de investigación con asociaciones de familias con hijos diagnosticados con TDAH de la provincia de Alicante (España) junto con entrevistas en profundidad a madres pertenecientes a alguna de las asociaciones. Por un lado, los resultados nos muestran las exigencias de la crianza como contexto de emergencia de la hiperactividad. En él se produce un aumento de las responsabilidades que el discurso hegemónico delega en la esfera familiar, donde el entrenamiento conductual de las familias ha pasado a ser considerado uno de los recursos terapéuticos. Por otro lado, queda manifiesto que la ideología maternal continúa depositando en las madres la responsabilidad material y simbólica de la crianza, que en estos casos también conlleva un abordaje terapéutico, contribuyendo a la insostenibilidad de un modelo que impacta significativamente en las vidas de las mujeres. Por lo tanto, podemos concluir que el discurso experto sobre el TDAH reúne las características para convertirse en epítome de la crianza científica contemporánea, que el conocimiento aplicado de los saberes psi y las neurociencias intensifican las responsabilidades de la maternidad, y que la crianza guiada se mantiene generizada, individualizada y descontextualizada.
Organyltellurium(IV) Bidentate Schiff Base Metal Complexes:
Synthesis, Characterization and Biological Activities
Authors: Antil Nidhi , Dalal Mahak , Verma K.K. , Garg Sapana
Published: July 2022

Condensation of 5-(hydroxymethyl)furan-2-carboxaldehyde with 4-toluidine yielded a Schiff base
(5-((p-tolylimino)methyl)furan-2-ol). A series of seven novel hexa-coordinated organyltellurium(IV)
complexes of type TeCl4·HMeFPT, RTeCl3·HMeFPT and R2TeCl2·HMeFPT (where R belongs to
4-methoxyphenyl, 4-hydroxyphenyl and 3-methyl-4-hydroxyphenyl; L belongs to HMeFPT i.e. Schiff
base have been prepared and characterized by molar conductance, IR, UV, 1H NMR, 13C NMR, mass
spectroscopy and elemental analysis. Thus according to spectroscopic studies, Schiff base ligand
functions as a NO donor bidentate ligand across all organyltellurium(IV) complexes via the azomethine
nitrogen atom and the oxygen atom of the furan ring. The above mentioned spectroscopic analysis
indicated that all the organyltellurium(IV) complexes have distorted octahedral geometry. Schiff base
and all the organyltellurium(IV) complexes had their geometry optimized and theoretical quantum
mechanical characteristics computed. The octahedral geometry for complexes is also suggested by
this computing analysis. The antimicrobial property of the Schiff base ligand and its
organyltellurium(IV) complexes was evaluated in vitro against different bacterial strains viz. A. clavatus,
C. albicans, A. niger, S. pyogenes, S. aureus, E. coli and P. aerugenosa. Antimicrobial property of
heterocyclic bidentate Schiff base and its organyltellurium(IV) complexes was found to be significantly
greater than that of some standard antibiotics.
Synthesis of Caffeic Acid Derivatives: Identification of
(E)-N-(4-Cyanobenzyl)-3-(3,4-dihydroxyphenyl)acrylamide
as an Anticancer Agent against Human Cervical Cancer Cells
Authors: Shwetha B. , Sudhanva M.S. , Thimmegowda N.R. , Anil Kumar B.M. , Jagadeesha G.S. , Guddappa H. , Prasanna D.S. , Dinesh R. , Shobith R. , Anandakumar C.S.
Published: July 2022

A novel series of natural compound-caffeic acid derivatives were synthesized by coupling with different
substituted amines and alkyl halides in an effort to enhance the anticancer activity and explore the
structure-activity relationship. The structures of the compounds were determined by 1H NMR and
mass spectroscopy analysis. Compounds were evaluated for inhibition against HeLa-cervical cancer
cell proliferation and results revealed that compound (E)-N-(4-cyanobenzyl)-3-(3,4-
dihydroxyphenyl)acrylamide (SHC5) exhibited potent antiproliferative activity with 5.2 μM
concentration and it is further confirmed by Hoechst/PI double staining and Annexin V/PI double
staining assay. Further, compound SHC5 was screened against other cancer cell lines namely K562,
Jurkat, HCT116 and MiaPaCa2 to test the specificity of the molecule and found to be ineffective.
Ethanol and Acetic Acid Induces Conformational
Changes in Zebrafish Dihydrofolate Reductase Protein
Authors: Acharya V.V. , Verma A.K. , Chaudhuri (Chattopadhyay) P.
Published: July 2022

An equilibrium unfolding research of the recombinant zDHFR would provide information on the
conformational changes of protein. In present work, the conformation of recombinant zDHFR was
investigated in presence of ethanol and acetic acid. Equilibrium unfolding of recombinant zDHFR
was monitored by enzymatic assay after denaturation by ethanol and acetic acid at 340 nm. Changes
in secondary and tertiary structure of zDHFR with increasing ethanol and acetic acid concentrations
were investigated in far-UV circular dichroism (CD) (190 to 250 nm) and fluorescence spectroscopy
(emission spectra from 300 to 400 nm with an excitation wavelength of 295 nm) methods. It has been
observed that in case of acetic acid-induced denaturation of zDHFR, the shift from native to denatured
state occurs in a single step, whereas intermediates or non-native states are found at low concentrations
of ethanol. The recent findings have significant implications for understanding how ethanol and acetic
acid affect protein structure.
A Simple Extraction Method for the Determination of Nicotine from Saliva
Authors: Taufik M. , Ardilla D. , Cahyady B. , Alfian Z. , Razali M.
Published: July 2022

A simple method is proposed for the determination of nicotine in the saliva of active smokers. Nicotine
was extracted from saliva at pH 10 with chloroform and n-hexane (60:40). The organic layer was
separated and put it in the centrifuge at 3000 rpm for 3 min and then evaporate at 35 ºC in bath water
with sonication. Water molecules were bound using silica gel GF 254 through cartridge solid phase
extraction (SPE). Spot test analysis was carried out using cyanogen bromide reagent produces an
orange colour which indicates nicotine positive. TLC analysis was carried out to produce qualitative
data with an Rf value in general = 0.75. The UV spectroscopic analysis at 260 nm produces the equation
= 0.0058x + 0.00342 and R2 = 0.9923. The concentration of nicotine obtained were 2.95, 2.96, 3.08,
3.22 and 2.79 μg/mL respectively.
Wild Edible Plants: Antioxidant Activities in Different Solvents and Quantification of Phenolic Compounds by HPLC
Authors: Seal Tapan , Pillai Basundhara , Chaudhuri Kausik
Published: July 2022

Wild edible plants (WEPs) are rich in antioxidants and diverse sections of the plant had been notably utilized as conventional and folklore medicine to cure various human ailments. This study was designed to evaluate the most effective solvent for extracting polyphenols from medicinally important WEPs which includes Coix lacryma-jobi, Herpetospermum pedunculosum, Plukenetia corniculata, Sonchus asper and Streptolirion volubile, which allows to offer medical guide for conventional use of the plant. Individual phenolic component concentrations were determined using RP-HPLC and total phenolic, total flavonoid and total flavonol were quantified using four different solvents. Aqueous ethanol (80%) is most effective solvent for polyphenol extraction amongst solvents of diverse polarities. The studied plants were found to be rich in total phenolics, flavonols, especially gallic acid (1.12 ± 0.33 μg/mg dry extract) and ferulic acid (4.03 ± 0.53 μg/mg dry extract) in the 80% aq. ethanol extract of H. pedunculosum. The correlation analyses of each solvent found out sturdy to susceptible connections amongst all examined parameters, with the best values (r and R2) in 80% aq. ethanol and chloroform, indicating that those solvents have an excessive ability for polyphenol extraction and antioxidant activity. The Principal component analysis revealed that based on the phenolics and polyphenolics content, the 80% aq. ethanol extract of H. pedunculosum was shown to be more potent than the other plants under investigation. Present findings display that aqueous ethanol extracts of the studied plants have better antioxidant activities than synthetic derivatives, indicating their prospective usefulness and ability to replace synthetic derivatives in consumable and medical products.
pH Measurement of Mixed Saliva using a Flow-injection
Sensor with a Tubular Carbon Electrode
Authors: Aronbaev S. , Raimkulova Ch. , Isakova D. , Berdymuradova F. , Aronbaev D.
Published: July 2022

Present work discusses the design of a flow-injection sensor for measuring pH in micro-volumes of
the sample. A carbon electrode with a capillary channel was used as a working electrode, through
which an electrolyte solution saturated with quinhydrone flows at a constant speed. The volume of the
analyzed sample was 0.1-0.2 mL. Compliance with the Nernst pH function with a slope of 53.1 ± 1.1
mV/pH was observed in the range of 1.0-7.5 pH. The sensor has been tested in the non-invasive
diagnostics of acid-base balance of the oral fluid. The analysis of mixed saliva was carried out in 30
practically healthy student volunteers with an intact row of teeth. The median pH value of 7.03 was
established, which corresponds to the physiological norm. At the same time, there is a predisposition
to caries in almost half of the subjects, since a high risk is determined in the formation of focal
demineralization of tooth enamel with the appearance of erosion of hard tooth tissues.
Computational, Spectral and Structural Studies of New
Hydrazinium Hydrogen Phthalate Monohydrate Salt
Authors: Rajasekar L. , Ahamed Hussain T.M. , Sivasankar B.N.
Published: July 2022

Pure single crystals of Lewis acid-base salt, hydrazinium hydrogen phthalate monohydrate (HHPMH)
has been synthesized, crystallized and isolated as a single crystal by slow evaporation method at room
temperature (22 ºC). Analysis of analytical, spectral, thermal and structural data confirmed the salt
formation in aqueous medium. The analytical data is in favour of the proposed composition
HOOC-C6H4COO N2H5·H2O. The compound crystallized in a monoclinic crystal system and P21/C
space group with cell parameters, a = 15.409(3) Å, b = 10.292(2) Å and c = 6.7087(12) Å. Though
strong intramolecular hydrogen bonding interaction is anticipated between acidic hydrogen of HHPMH
and deprotonated carboxylate oxygen surprisingly in the present case it is absent and a weak interaction
is observed between acidic hydrogen and water molecule, which is quite evident from the ORTEP
diagram. The nature of interactions between hydrazine cation and hydrogen phthalate ion and the
crystal packing diagram from various types of intermolecular contacts were determined by Hirshfeld
surface analysis. The compound was stable up to 40 ºC and undergoes dehydration from 40-70 ºC with
an endotherm at 47 ºC. The experimental and theoretical infrared spectra are also in favour of the
formation of ionic crystal. The molecular structure was optimized using B3LYP method by 6-311G
(d,p) basis set. The energy gap between HOMO and LUMO is 7.7340 eV. Theoretical calculation
based on DFT studies and natural bond orbital analyses has been carried out to evaluate the molecular
electrostatic potential. The structure was optimized by DFT and the vibrational frequencies were
calculated. Comparison of experimental and optimized structures revealed that there is a good
coincidence between the two.
GC-MS Profiling of Phytobioconstituents Present in Andrographis paniculata (Burm.f.) Nees
Extract and Pharmacokinetic and Toxicity Properties by ADME/Tox Analysis
Authors: Saxena Riden , Shrinet Kriti , Saxena Ritika , Panwar Yatender Singh , Jain Madhu
Published: July 2022

Andrographis paniculata, commonly known as the “King of Bitters” has traditionally been used as a
medicinal herb. The metabolite composition of A. paniculata is generally determined by its properties,
which may be influenced by a range of factors, one of which is the part of the plant extracted. The
objective of this research is to identify and characterize the putative metabolite composition in n-hexane
extract of stem and leaf using gas chromatography-mass spectrometry. A total of 22 different
phytobioconstituents were identified, including flavonoids, terpenoids, fatty acids, phenolic acids,
quinones, alkaloids and vitamin. The pharmacokinetic properties of the identified phytobioconstituents,
like drug-likeness and toxicity, were also predicted by ADME/Tox analysis. Phytobioconstituents,
predicted to be drug-like can be further investigated as ligands by using in silico docking approaches,
for disease targets. The study provides empirical evidence for future study that might lead to their
therapeutic applications and industrial product development.
Development of an evidence-based complementary feeding practice module for mothers using the combined Delphi Method
Authors: Andriani Rini , Sjarif Damayanti Rusli , Supriyatno Bambang , Kekalih Aria , Gunardi Hartono , Idris Ika Karlina
Published: July 2022

Background Malnutrition in infants remains a challenge in Indonesia. Malnutrition often arises as a result of errors in complementary feeding practices. An education module for Indonesian mothers may help them correctly implement complementary feeding practices.

Objective To develop a module on correct complementary feeding practices for infants aged 6-9 months that can be read and understood by Indonesian mothers.

Methods We performed qualitative research using the two-round Delphi method combined with group discussions. The first round listed the most important sub-themes of the module, while the second round sought approval for the module from experts. The Delphi team members were included using purposive and snowball sampling methods. Expert opinions were summarized and rearranged using the Steps for Coding and Theorization (SCAT) method.

Results Ten experts were included in the Delphi team, with a mean duration of work experience of 28.5 (SD 12.37) years. The correct practices for giving complementary foods according to scientific evidence was named the ABC-Makanan PendampingASI/MPASI-Press (“Printed ABC of Complementary Feeding”) module and was summarized into four main topics: timely, adequate, safe, and responsive feeding. This module was made using language, photos, and images that were easily understood by mothers and included the suitable nutritional compositions to meet the needs of infants aged 6-9 months.

Conclusion We developed the ABC-MPASI-Press module based on scientific evidence and experts’ reviews using the combined Delphi method. This educational guide is expected to inform mothers about correct complementary feeding practices for infants aged 6-9 months in order to prevent malnutrition.
Mesenchymal stem cells therapy in children with end-stage kidney disease
Authors: Hidayati Eka Laksmi , Fahlevi Reza , Puspitasari Henny Adriani , Rahmadhany Anisa , Pardede Sudung Oloan
Published: July 2022

Chronic kidney disease (CKD) is a major health problem worldwide, with increasing incidence and prevalence. While the incidence of CKD in children is relatively low, CKD contributes to major health problems and has many long-term effects.1 Chronic kidney disease is characterized by a gradual decline in kidney function over time. The Kidney Disease Improving Global Outcomes (KDIGO) report defined CKD as an abnormality of renal structure or function with decreased glomerular filtration rate (GFR) that lasts more than three months. Chronic kidney disease is classified into 5 stages based on the GFR value.2                Patients with stage V CKD transition from progressive disease to irreversible, terminal, end-stage kidney disease (ESKD). To date, the standard of ESKD management has been kidney replacement therapy, consisting of hemodialysis (HD), peritoneal dialysis (PD), and/or kidney transplantation. Complexity and cost of kidney care have obvious consequences on the availability of kidney replacement therapy for children, especially in developing countries. Dialysis provides only partial replacement of renal functions, especially clearance and fluid balance, but does not cure the disease. Kidney transplantation is a curative management, but donor availability for pediatric patients remains challenging