bluuebunny/crossref_metadata_2025 huggingface dataset:
A ductile seismic design strategy for the cross-aisle direction of racking systems
Authors: Tsarpalis Dimitrios , Vamvatsikos Dimitrios , Natali Agnese , Morelli Francesco , Delladonna Filippo , Vantusso Emanuele
Published: May 2024

Due to their lightness and simple connectivity, steel racking systems are typically considered as “low-dissipative” structures, which is reflected in the modern seismic codes by the absence of capacity design and the adoption of low behaviour factors. This limited capability of stress redistribution significantly increases the vulnerability of racks under beyond-design seismic hazards and raises the demand for more resilient designs. Along these lines, the proposed Plastic Ovalization Strategy (POS) attempts to increase the ductility of the individual upright frames comprising the cross-aisle direction of racks, and at the same time to preserve their low-cost and easy-to-assemble nature. This is achieved by tasking the bearing failure mechanism of the diagonal bolt hole to absorb seismic deformations, while capacity design is employed to keep the rest of the structure in the elastic zone. Following a detailed discussion on the motives and basic principles of the strategy, two high-rise racking systems are designed twice by professional engineers, once using standard approaches and then by additionally employing the proposed POS rules. Finally, the two design solutions are compared by conducting a comprehensive seismic assessment, which employs a phenomenological macro-model comprising elastic elements and nonlinear springs to simulate the bearing failure mechanism.
Chlorella vulgaris algae ameliorates chlorpyrifos toxicity in Nile tilapia with special reference to antioxidant enzymes and Streptococcus agalactiae infection
Authors: Tawfeek Walaa S. , Kassab Amina S. , Al-Sokary Eman T. , Abass Mona E. , Sherif Ahmed H.
Published: May 2024

Background

Chlorpyrifos (CPF) is a widely used pesticide in the production of plant crops. Despite rapid CPF biodegradation, fish were exposed to wastewater containing detectable residues. Recently, medicinal plants and algae were intensively used in aquaculture to replace antibiotics and ameliorate stress impacts.

Methods and results

An indoor experiment was conducted to evaluate the deleterious impacts of CPF pollution on Nile tilapia health and the potential mitigation role of Chlorella vulgaris algae. Firstly, the median lethal concentration LC50 − 72 h of CPF was determined to be 85.8 µg /L in Nile tilapia (35.6 ± 0.5 g body weight) at a water temperature of 27.5 °C. Secondly, fish were exposed to 10% of LC50 − 72 h for six weeks, and tissue samples were collected and examined every two weeks. Also, Nile tilapia were experimentally infected with Streptococcus agalactiae. Exposed fish were immunosuppressed expressed with a decrease in gene expressions of interleukin (IL) 1β, IL-10, and tumor necrosis factor (TNF)-α. Also, a decline was recorded in glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) gene expression in the head kidney tissue. A high mortality rate (MR) of 100% was recorded in fish exposed to CPF for six weeks and challenged with S. agalactiae. Fish that received dietary C. vulgaris could restore gene expression cytokines and antioxidants compared to the control. After six weeks of CPF exposure, fish suffered from anemia as red blood cell count (RBCs), hemoglobin (Hb), and packed cell volume (PCV) significantly declined along with downregulation of serum total protein (TP), globulin (GLO), and albumin (ALB). Liver enzymes were significantly upregulated in fish exposed to CPF pollution, alanine aminotransferase (ALT) (42.5, 53.3, and 61.7 IU/L) and aspartate aminotransferase (AST) (30.1, 31.2, and 22.8) after 2, 4, and 6 weeks, respectively. On S. agalactiae challenge, high MR was recorded in Nile tilapia exposed to CPF (G3) 60%, 60%, and 100% in week 2, week 4, and week 6, and C. vulgaris provided a relative protection level (RPL) of 0, 14.29, and 20%, respectively.

Conclusions

It was concluded that CPF pollution induces immunosuppressed status, oxidative stress, and anemic signs in Nile tilapia. In contrast, C. vulgaris at a 50 g/kg fish feed dose could partially ameliorate such withdrawals, restoring normal physiological parameters.
The role of independent directors’ tenure and network in controlling real-earnings management practices
Authors: Asad Muhammad , Akbar Saeed , Mollah Sabur
Published: May 2024

Manipulating real activities is generally regarded as more damaging to a firm’s long-term growth and value than accrual-based manipulations. We consider this point of view and build on the agency theory framework for investigating the role of independent directors’ (INDs’) tenure and connection to several boards in controlling real-earnings management (REM) practices. We analyze a sample of UK listed non-financial companies over the period between 2005 and 2018. The potential endogeneity issue was controlled by the application of the two-step system-GMM estimations. The research findings suggest that REM was lower in those firms whose INDs were connected to several boards at a time. The findings also show that the association between INDs’ tenure and REM varied with the phases of their tenure. Directors in the early stage of their tenure are less effective at controlling REM, however, as their tenure grew, they generate better oversight over the management conduct, thereby reducing REM. Contrary to this, extended tenure is shown as positively associated with higher REM practices. The overall findings thus suggest that the board monitoring role protects the stakes of the shareholders by constraining REM when INDs have better expertise and rich information acquired through their presence on multiple boards—and when they have moderate board tenure, which is neither too short nor too long. We argue that due to the importance of the role of INDs in the current global scenario this study has policy implications.
Characterizing human postprandial metabolic response using multiway data analysis
Authors: Yan Shi , Li Lu , Horner David , Ebrahimi Parvaneh , Chawes Bo , Dragsted Lars O. , Rasmussen Morten A. , Smilde Age K. , Acar Evrim
Published: May 2024

Introduction

Analysis of time-resolved postprandial metabolomics data can improve our understanding of the human metabolism by revealing similarities and differences in postprandial responses of individuals. Traditional data analysis methods often rely on data summaries or univariate approaches focusing on one metabolite at a time.

Objectives

Our goal is to provide a comprehensive picture in terms of the changes in the human metabolism in response to a meal challenge test, by revealing static and dynamic markers of phenotypes, i.e., subject stratifications, related clusters of metabolites, and their temporal profiles.

Methods

We analyze Nuclear Magnetic Resonance (NMR) spectroscopy measurements of plasma samples collected during a meal challenge test from 299 individuals from the COPSAC2000 cohort using a Nightingale NMR panel at the fasting and postprandial states (15, 30, 60, 90, 120, 150, 240 min). We investigate the postprandial dynamics of the metabolism as reflected in the dynamic behaviour of the measured metabolites. The data is arranged as a three-way array: subjects by metabolites by time. We analyze the fasting state data to reveal static patterns of subject group differences using principal component analysis (PCA), and fasting state-corrected postprandial data using the CANDECOMP/PARAFAC (CP) tensor factorization to reveal dynamic markers of group differences.

Results

Our analysis reveals dynamic markers consisting of certain metabolite groups and their temporal profiles showing differences among males according to their body mass index (BMI) in response to the meal challenge. We also show that certain lipoproteins relate to the group difference differently in the fasting vs. dynamic state. Furthermore, while similar dynamic patterns are observed in males and females, the BMI-related group difference is observed only in males in the dynamic state.

Conclusion

The CP model is an effective approach to analyze time-resolved postprandial metabolomics data, and provides a compact but a comprehensive summary of the postprandial data revealing replicable and interpretable dynamic markers crucial to advance our understanding of changes in the metabolism in response to a meal challenge.
Postmortem metabolomics: influence of time since death on the level of endogenous compounds in human femoral blood. Necessary to be considered in metabolome study planning?
Authors: Steuer Andrea E. , Wartmann Yannick , Schellenberg Rena , Mantinieks Dylan , Glowacki Linda L. , Gerostamoulos Dimitri , Kraemer Thomas , Brockbals Lana
Published: May 2024

Introduction

The (un)targeted analysis of endogenous compounds has gained interest in the field of forensic postmortem investigations. The blood metabolome is influenced by many factors, and postmortem specimens are considered particularly challenging due to unpredictable decomposition processes.

Objectives

This study aimed to systematically investigate the influence of the time since death on endogenous compounds and its relevance in designing postmortem metabolome studies.

Methods

Femoral blood samples of 427 authentic postmortem cases, were collected at two time points after death (854 samples in total; t1: admission to the institute, 1.3–290 h; t2: autopsy, 11–478 h; median ∆t = 71 h). All samples were analyzed using an untargeted metabolome approach, and peak areas were determined for 38 compounds (acylcarnitines, amino acids, phospholipids, and others). Differences between t2 and t1 were assessed by Wilcoxon signed-ranked test (p < 0.05). Moreover, all samples (n = 854) were binned into time groups (6 h, 12 h, or 24 h intervals) and compared by Kruskal–Wallis/Dunn’s multiple comparison tests (p < 0.05 each) to investigate the effect of the estimated time since death.

Results

Except for serine, threonine, and PC 34:1, all tested analytes revealed statistically significant changes between t1 and t2 (highest median increase 166%). Unpaired analysis of all 854 blood samples in-between groups indicated similar results. Significant differences were typically observed between blood samples collected within the first and later than 48 h after death, respectively.

Conclusions

To improve the consistency of comprehensive data evaluation in postmortem metabolome studies, it seems advisable to only include specimens collected within the first 2 days after death.
Childhood cancer models of survivorship care: a scoping review of elements of care and reported outcomes
Authors: Bradford Natalie , Chan Raymond Javan , Skrabal Ross Xiomara , Thamm Carla , Sharwood Erin , Pole Jason , Cashion Christine , Nekhlyudov Larissa
Published: May 2024

Purpose

This study aimed to systematically map elements of care and respective outcomes described in the literature for different models of post-treatment care for survivors of childhood cancer.

Methods

MEDLINE, CINAHL, and Embase were searched with combinations of free text terms, synonyms, and MeSH terms using Boolean operators and are current to January 2024. We included studies that described post-treatment cancer survivorship models of care and reported patient or service level elements of care or outcomes, which we mapped to the Quality of Cancer Survivorship Care Framework domains.

Results

Thirty-eight studies with diverse designs were included representing 6101 childhood cancer survivors (or their parent/caregiver) and 14 healthcare professionals. A diverse range of models of care were reported, including paediatric oncologist-led long-term follow-up, multi-disciplinary survivorship clinics, shared-care, and primary care-led follow-up. Elements of care at the individual level most commonly included surveillance for cancer recurrence as well as assessment of physical and psychological effects. At the service level, satisfaction with care was frequently reported but few studies reported how treatment-related-late effects were managed. The evidence does not support one model of care over another.

Conclusions

Gaps in evidence exist regarding distal outcomes such as costs, health care utilization, and mortality, as well as understanding outcomes of managing chronic disease and physical or psychological effects. The findings synthesized in this review provide a valuable reference point for future service planning and evaluation.

Implications for Cancer Survivors

Decades of research highlight the importance of survivorship care for childhood cancer survivors who are at risk of serious treatment-related late effects. This review emphasizes there is no single, ‘one-size fits all’ approach for delivering such care to this vulnerable population.
Biologischer Abbau von Aminophosphonaten
Authors: Riedel Ramona , Commichau Fabian , Benndorf Dirk , Martienssen Marion
Published: May 2024

Application of commercial aminophosphonates such as glyphosate (GS) or chelating agents in detergent are daily used at large scale worldwide. Only little is known about the potential biodegradation of the latter. Here we describe the characterization of the new strain Ochrobactrum sp. BTU1 isolated from a LC/MS standard solution. The strain is capable to degrade all investigated aminophosphonates including GS.
Vesikel-gebundene und frei zirkulierende miRNAs in Alterungsprozessen
Authors: Wagner Viktoria , Keller Andreas
Published: May 2024

Altered intercellular communication is one of the molecular hallmarks of aging. Microvesicles carrying different kinds of molecules, like proteins and RNAs are important agents of short- and long-range communication in the body. MicroRNAs (miRNAs) are especially interesting targets to study in this context, as these molecules can regulate multiple targets in the recipient cells via complementary base-pair binding and thereby regulate a complex process such as aging.
Sectorial evaluation and characterization of internal marketing orientation through multicriteria analysis
Authors: Muñoz María M. , Kazakov Sergey , Ruiz-Alba Jose L.
Published: May 2024

This research carries out a comparative analysis of the Internal Market Orientation (IMO) to a sample of small and medium enterprise companies, which has been divided into nine groups based on their business sectors. Applying the statistical technique of structural equations, the coefficients of four IMO inputs in each business sector are obtained. Next, the PROMETHEE multicriteria technique is applied to obtain a composite indicator of the IMO implementation of each business sector. The value of the composite indicator together with the GAIA plane allow to distinguish the differences of the IMO profiles, their strengths and their weaknesses. The results show the divergences in the IMO inputs according to the sector, which is evidence that the business sector is a predictor of the IMO implementation of a company.
Wastewater purification and recycling using plants in an arid environment for agricultural purposes: case of the Algerian Sahara
Authors: Bendida Ali , Kendouci Mohammed Amin , Mebarki Saliha , Tidjani Abdellatif El-Bari
Published: May 2024

The aim of this study is to apply a water treatment technique (phyto-purification) in the Algerian Sahara, an arid region, to resolve the scarcity of irrigation, recycled wastewater and preserve Saharian ecosystems composed of sand and two species of aquatic plants: Typha latifolia and Imperata cylindrica. The choice of these plants was determined based on the natural vegetation, soil and climatic characteristics of the study area. To this end, we developed an experimental pilot composed of three tanks measuring 30 cm × 35 cm × 45 cm, arranged with a filter bed of sand and gravel. Two of these tanks are sown with the above-mentioned plants, while the third tank, serving as a control, is not. The values of the main wastewater pollution parameters, namely total nitrogen compounds, ammonium (NH4+), chemical oxygen demand (COD) and suspended solids measured at the outlet of the device, substantiate the performance of this treatment system. Indeed, the nitrogen reduction rate increased from 63% in the unplanted control filters to around 80% in the planted filters, and from 81 to 88% for NO3−. Regarding chemical oxygen demand (COD), the reduction rate exceeds 88.37% for the three tanks. The study of the analytical approach to modeling the purification kinetics reveals that the kinetics of COD and NH4+ are well correlated with the first-order model, with an explained variance varying between 68.1 and 81.6% for COD and 83.5 and 92.3% for ammonium. The Riverside diagram highlights that all treated water samples fall into the low sodium risk and high salinity risk class. Build on the Na% values; all purified waters have characteristics suitable for water use for irrigation.
The analysis of transcriptomic signature of TNBC—searching for the potential RNA-based predictive biomarkers to determine the chemotherapy sensitivity
Authors: Supplitt Stanislaw , Karpinski Pawel , Sasiadek Maria , Laczmanski Lukasz , Kujawa Dorota , Matkowski Rafal , Kasprzak Piotr , Abrahamowska Mariola , Maciejczyk Adam , Iwaneczko Ewelina , Laczmanska Izabela
Published: May 2024

Neoadjuvant chemotherapy is the foundation treatment for triple-negative breast cancer (TNBC) and frequently results in pathological complete response (pCR). However, there are large differences in clinical response and survival after neoadjuvant chemotherapy of TNBC patients. The aim was to identify genes whose expression significantly associates with the efficacy of neoadjuvant chemotherapy in patients with TNBC. Transcriptomes of 46 formalin-fixed paraffin-embedded (FFPE) tumor samples from TNBC patients were analyzed by RNA-seq by comparing 26 TNBCs with pCR versus 20 TNBCs with pathological partial remission (pPR). Subsequently, we narrowed down the list of genes to those that strongly correlated with drug sensitivity of 63 breast cancer cell lines based on Dependency Map Consortium data re-analysis. Furthermore, the list of genes was limited to those presenting specific expression in breast tumor cells as revealed in three large published single-cell RNA-seq breast cancer datasets. Finally, we analyzed which of the selected genes were significantly associated with overall survival (OS) in TNBC TCGA dataset. A total of 105 genes were significantly differentially expressed in comparison between pPR versus pCR. As revealed by PLSR analysis in breast cancer cell lines, out of 105 deregulated genes, 42 were associated with sensitivity to docetaxel, doxorubicin, paclitaxel, and/or cyclophosphamide. We found that 24 out of 42 sensitivity-associated genes displayed intermediate or strong expression in breast malignant cells using single-cell RNAseq re-analysis. Finally, 10 out of 24 genes were significantly associated with overall survival in TNBC TCGA dataset. Our RNA-seq-based findings suggest that there might be transcriptomic signature consisted of 24 genes specifically expressed in tumor malignant cells for predicting neoadjuvant response in FFPE samples from TNBC patients prior to treatment initiation. Additionally, nine out of 24 genes were potential survival predictors in TNBC. This group of 24 genes should be further investigated for its potential to be translated into a predictive test(s).
Moduli space of bi-invariant metrics
Authors: Flores Torres Juan
Published: May 2024

In this work, we focus on describing the space of bi-invariant metrics in a Lie group up to isometry. i.e, metrics invariant under both left and right translations. We show that $$\mathfrak {BI}$$
BI
, the moduli space of bi-invariant metrics, is an orbifold. Moreover, we give an explicit description of this orbifold, and of $$\mathfrak {EBI}$$
EBI
, the space of bi-invariant metrics equivalent under isometries and scalar multiplies.
Recent Developments in RFT Encourage Interbehavioral Field-Based Views of Human Language and Cognition: A Preliminary Analysis
Authors: Harte Colin , Barnes-Holmes Dermot
Published: May 2024

Relational frame theory (RFT) as a behavior-analytic approach to understanding human language and cognition is now over 40 years old. However, the last 8 years have seen a relatively intense period of empirical and conceptual developments within the theory. Some of this work has begun to draw on early and much underplayed features of RFT, including field-theoretical analyses and concepts. These analyses are relatively nascent and thus the current article aims to provide a relatively detailed example of a field-theoretical analysis of a specific RFT research program. We begin with a brief overview of the “traditional” RFT approach to human language and cognition, followed by a summary of recent research involving the implicit relational assessment procedure (IRAP) and the differential arbitrarily applicable relational responding effects (DAARRE) model. We then go on to consider the DAARRE model in the context of J. R. Kantor’s interbehavioral formula for the psychological event. Having done so, we conclude that the challenge involved in analyzing increasingly complex forms of human language and cognition appears to call for more field-based theorizing in some form or another.
The Role of Organized Activities in Supporting Youth Social Capital Development: A Qualitative Meta-Synthesis
Authors: Boat Ashley A. , Poparad Heather , Seward Miray D. , Scales Peter C. , Syvertsen Amy K.
Published: May 2024

Social capital provides young people with a web of supportive relationships that can be leveraged in pursuit of education, career, and life goals. Organized activities, an umbrella term for extracurricular activities, after-school programs, and youth development programs, are important developmental contexts for building social capital. The purpose of this study was to illuminate the developmental pathway through which social capital development occurs in organized activities. A qualitative meta-synthesis was conducted using 33 articles that met inclusion criteria across five databases (e.g., ERIC, PsycINFO) between June 2022 and May 2023. Thematic analysis was used to identify malleable organized activity features that act as levers for social capital promotion. Seven thematically aligned features were identified, including (1) organizational partnerships, (2) organizational supporting structures, (3) relationally strong climate, (4) staff mindsets and skills, (5) youth mindsets and skills, (6) increased social capital opportunities, and (7) increased social capital activation. These seven themes were used to construct an empirically-grounded model that posits a process through which organized activities support youth social capital development. Implications for intentionally strengthening organized activities’ capacity to support youth social capital are discussed.
Mechanism of overburden fracture induced earthquakes in coal seam mining
Authors: Zhang Quan , Zou Junpeng , Jiao Yu-Yong , Jiang Yujing , Kou Qihua
Published: May 2024

Mining-induced earthquakes are unnatural seismic events that frequently occur in high-position hard and thick rock strata during coal mining. Considering the frequent occurrence of strong mining-induced earthquakes in the Dongtan mining area, this study analysed the fracture migration characteristics of hard and thick rock strata and the focal mechanism of mining-induced earthquakes based on Volasov’s thick-plate and moment tensor inversion theories. The results showed that the main key strata were difficult to break under single-panel mining conditions because of the thick and high-strength rock strata and breakage of the main key strata is caused by multiple-panel mining. Volasov’s thick-plate theoretical calculation indicated an initial fracture span of the main key strata was 314 m, which is consistent with the actual mining distance of the working face. This verified that strong mining-induced earthquakes were induced by the initial fracture of the main key strata. In coal mining, the pure shear failure type of mining-induced earthquakes indicated the highest percentage, and the shear fracture of rock strata was the primary cause of strong mining-induced earthquakes. The dip angle of the focal fracture surface in mining-induced earthquakes was generally within 15°. Through an analysis of the focal mechanism of mining-induced earthquakes, it has a certain guiding role in explaining the mechanism of mining-induced earthquakes.
The Port Macquarie Settlement, New South Wales, 1821–1847: Interconnections within Landscapes of Convict Labor and Industry
Authors: Phillips Crystal , Gibbs Martin
Published: May 2024

This article explores the convict-punishment settlement of Port Macquarie on the mid-north coast of New South Wales between 1821 and 1847. Synthesizing previous and new historical and archaeological research, it identifies a range of major and minor sites of labor, accommodation, reform, and punishment within the settlement’s landscape during its period as a restricted convict prison from 1821 to 1830. From this it reconstructs the network of labor provision and infrastructure development, which we argue was not just about making the settlement economically self-sustaining, but also intended to create the framework for a transition to a “free” settlement. To this end this article also examines the ways in which that transformation occurred, with former sites of convict labor and the convicts themselves transitioning from government control to private settlers, until the withdrawal of the government infrastructure for convict management in 1847.
A comprehensive review on the health benefits, phytochemicals, and enzymatic constituents for potential therapeutic and industrial applications of Turkey tail mushrooms
Authors: Camilleri Emma , Blundell Renald , Baral Bikash , Karpiński Tomasz M. , Aruci Edlira , Atrooz Omar M.
Published: May 2024

This comprehensive literature review delves into the multifaceted attributes of Trametes versicolor, commonly known as turkey tail mushroom. The turkey tail mushroom stands as a noteworthy source of diverse bioactive compounds with potent health benefits. This review offers a contemporary synthesis of its phytochemical constituents and their multifaceted impacts on human health. The mushroom's intricate composition, encompassing polysaccharides, phenols, and triterpenes, underpins its remarkable therapeutic potential. Focusing on key attributes such as anti-cancer, anti-microbial, and immunomodulatory activities, this review delves into the intricate mechanisms by which the turkey tail mushroom exerts its effects. In addition, the exploration extends to the enzymatic constituents inherent in the mushroom and their industrial significance. Mechanisms of action for both phytochemicals and enzymes are studied, providing a well-rounded understanding of their roles in conferring therapeutic and industrial benefits. This synthesis of research aims to provide an up-to-date perspective on turkey tail mushrooms' versatile applications. By intertwining the exploration of health benefits and enzymatic constituents, this review offers insights into the potential of harnessing this natural resource for innovative therapeutic strategies and industrial applications. Overall, it contributes to the advancement of knowledge and utilisation of turkey tail mushrooms' diverse properties for human health and industrial progress.
The Alteration in Physiological Status, Growth and Essential Oil Profile of French Marigold (Tagetes patula L.) Owing to Seaweed Extract and Salicylic Acid Application
Authors: El-Ziat Rasha Ahmed Mohamed , Saudy Hani Saber , Hewidy Mohammed
Published: May 2024

Purpose

Medicinal plants show a relevant importance in human life and health. The use of natural substances in crop management is not only significant for the plant healthy growth and yield, but also for obtaining safe products. The study aimed to examine the effect of seaweed extract (SW) as a natural source of nutrition and salicylic acid (SA) on plant health, physiology and essential oil profile of French marigold (Tagetes patula L.).

Methods

Three levels of salicylic acid, SA50, SA100 and SA200, (50, 100, and 200 mg L− 1) and three levels of seaweed extract, SW2, SW4 and SW6 (2.0, 4.0, and 6.0 ml L− 1), in comparison with control treatment (tap water) were applied as foliar sprayings. The seven treatments were arranged in randomized complete block design and were replicated thrice in two growing seasons (2020 and 2021).

Results

Findings pointed out that SA200 increased plant height, branches number plant− 1, stem diameter, leaf area, leaves number plant− 1, plant fresh weight, and plant dry weight by 32.9, 112.2, 59.2, 34.4, 44.3, 33.0 and 56.9% (averages of the two seasons), respectively, compared to the control treatment (tap water). SW6 increased carotenoids content by 34.8 and 46.4% in 2020 and 2021 seasons, respectively. Salicylic acid at the rate of 200 mg L− 1 along seaweed extract at 6 ml L− 1 gave the highest values of total sugars and free amino acids. SA200 alone recorded the maximal value of peroxidase activity surpassing the other treatments. SW6 possessed the greatest essential oil content in both seasons, statistically equaling SA200 in the first season. Huge variations in essential oil profile were recorded under the tested trial treatments.

Conclusion

It could be concluded that salicylic acid and seaweed extract foliar application unveiled their involvement in diverse physiological and developmental responses; pigment formation, enzyme activities, flower induction, nutrient uptake, essential oil metabolism, and overall plant growth and development. It is recommended to use the highest concentrations of the tested substances (SA at 200 mg L− 1 or SW at 6.0 ml L− 1) for achieving distinctive improvements in physiological responses of French marigold plant.
The Performance of Modified Asphalt Mixtures with Different Lengths of Glass Fiber
Authors: Khaled Teba Tariq , Kareem Abbaas I. , Mohamad Safaa A. , Al-Hamd Rwayda Kh. S. , Minto Andrew
Published: May 2024

One practical option for modifying an asphalt mixture’s performance is to use additives. This will help the mixture perform better against the damaging effects of traffic, loads, and climatic variations. In this regard, glass fiber (GF) has drawn much interest because of its positive effect. Therefore, this paper attempts to study the effect of glass fiber length and content on the performance and strength of asphalt mixtures. It also aims to determine the optimum glass fiber content and the best glass fiber length of modified asphalt mixtures. An experimental program is carried out, which includes the Marshall test, volumetric properties, freeze-thaw splitting test, immersion Marshall test, and wheel tracking test to characterize related properties of glass fiber incorporated in asphalt mixtures. Seven different percentages (0, 0.25, 0.5, 0.75, 1, 1.25, and 1.5) of glass fiber by total weight of aggregates in three various lengths are used to design 19 asphalt mixtures. Based on the results obtained, the performance of the asphalt mixture was enhanced remarkably after adding glass fiber. The use of various lengths of glass fiber led to a better-quality asphalt mixture in terms of volumetric properties, moisture damage resistance, and permanent deformation resistance. Specifically, asphalt mixtures made with (0.5%) glass fiber illustrated the highest quality, and adding (20 mm) length of glass fiber was better than (10 mm and 30 mm) glass fiber lengths. The results also show that adding (10 mm and 30 mm) lengths of glass fiber can improve the resistance of asphalt mixtures to water damage and permanent deformation compared with the control mixture (M0). The findings indicate the applicability of 20 mm glass fiber length in asphalt mixtures to achieve better resistance against moisture and reduce the chance of irreparable permanent deformation under growing traffic loads and hot climate changes. Although the inclusion of glass fiber in asphalt mixtures led to a modest increase (6%) in overall cost, the effective improvement in performance and extension of the service life of the asphalt pavement constitute a convincing argument for this approach, making it an attractive option. Finally, it was concluded that a higher amount of glass fiber (i.e., > 0.5%) and a length greater than (20 mm) could diminish the positive effect of glass fiber to improve the properties of glass fiber asphalt mixtures.
Factors Affecting Shooting Performance in Laser Run
Authors: Hoffmann Christine
Published: May 2024

Purpose

Laser Run combines running and shooting with a laser pistol in multiple laps with high cardio-vascular stress. The aim of this study was to analyze the impact of shooting rate, shooting rhythm, heart rate, and core stability on the overall performance.

Methods

During a qualification race with 23 elite athletes heart rate and shooting performance were measured. The shooting rate and rhythm were then calculated and trunk strength endurance was determined in a separate test.

Results

Firing an average of 10.2 ± 3.9 shots per lap, the athletes spent a mean of 23.0 ± 12.0 s at the shooting range. The mean shooting rate was approximately 2.4 s between two shots. The results indicated a regular shooting rhythm to be more important than high shooting rate. The variation of the shooting rate showed a strong correlation with the overall shooting performance (r = 0.77). Athletes shoot at a heart rate close to 95% of their maximum heart rate. However, deviations do not seem to influence on the shooting performance, whereas core strength endurance obviously has a strong impact on shooting performance (r = −0.57).

Conclusion

Athletes must train to shoot with high heart rates and find a balance between high shooting rate and precision. A constant shooting rhythm and good core stability appear to be particularly important for high performance.
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments
Authors: Kuczyńska Katarzyna , Bartkowska Katarzyna , Djavadian Ruzanna , Zwierzyńska Ewa , Wojcieszak Jakub
Published: May 2024

Background

Synthetic cathinones (SC) constitute the second most frequently abused class of new psychoactive substances. They serve as an alternative to classic psychostimulatory drugs of abuse, such as methamphetamine, cocaine, or 3,4-methylenedioxymethamphetamine (MDMA). Despite the worldwide prevalence of SC, little is known about their long-term impact on the central nervous system. Here, we examined the effects of repeated exposure of mice during infancy, to 3,4-methylenedioxypyrovalerone (MDPV), a SC potently enhancing dopaminergic neurotransmission, on learning and memory in young adult mice.

Methods

All experiments were performed on C57BL/6J male and female mice. Animals were injected with MDPV (10 or 20 mg/kg) and BrdU (bromodeoxyuridine, 25 mg/kg) during postnatal days 11–20, which is a crucial period for the development of their hippocampus. At the age of 12 weeks, mice underwent an assessment of various types of memory using a battery of behavioral tests. Afterward, their brains were removed for detection of BrdU-positive cells in the dentate gyrus of the hippocampal formation with immunohistochemistry, and for measurement of the expression of synaptic proteins, such as synaptophysin and PSD95, in the hippocampus using Western blot.

Results

Exposure to MDPV resulted in impairment of spatial working memory assessed with Y-maze spontaneous alternation test, and of object recognition memory. However, no deficits in hippocampus-dependent spatial learning and memory were found using the Morris water maze paradigm. Consistently, hippocampal neurogenesis and synaptogenesis were not interrupted. All observed MDPV effects were sex-independent.

Conclusions

MDPV administered repeatedly to mice during infancy causes learning and memory deficits that persist into adulthood but are not related to aberrant hippocampal development.
Physiological and molecular bases of the nickel toxicity responses in tomato
Authors: Yu Hao , Li Weimin , Liu Xiaoxiao , Song Qianqian , Li Junjun , Xu Jin
Published: May 2024

Nickel (Ni), a component of urease, is a micronutrient essential for plant growth and development, but excess Ni is toxic to plants. Tomato (Solanum lycopersicum L.) is one of the important vegetables worldwide. Excessive use of fertilizers and pesticides led to Ni contamination in agricultural soils, thus reducing yield and quality of tomatoes. However, the molecular regulatory mechanisms of Ni toxicity responses in tomato plants have largely not been elucidated. Here, we investigated the molecular mechanisms underlying the Ni toxicity response in tomato plants by physio-biochemical, transcriptomic and molecular regulatory network analyses. Ni toxicity repressed photosynthesis, induced the formation of brush-like lateral roots and interfered with micronutrient accumulation in tomato seedlings. Ni toxicity also induced reactive oxygen species accumulation and oxidative stress responses in plants. Furthermore, Ni toxicity reduced the phytohormone concentrations, including auxin, cytokinin and gibberellic acid, thereby retarding plant growth. Transcriptome analysis revealed that Ni toxicity altered the expression of genes involved in carbon/nitrogen metabolism pathways. Taken together, these results provide a theoretical basis for identifying key genes that could reduce excess Ni accumulation in tomato plants and are helpful for ensuring food safety and sustainable agricultural development.
Impact of ataxia aetiology on self-reported mental health, fatigue, cognition and ataxia symptom severity
Authors: Jenkins Emma , Dunger Warren
Published: May 2024

Introduction

It has been increasingly recognised that the impact of Ataxia extends beyond physical and motor symptomology. However, it is less known whether self-reported non-motor and ataxia symptom severity varies across ataxias of differing aetiology, which would have important implications for providing more targeted treatment.

Aim

This study aimed to investigate the impact of ataxia aetiology (hereditary, acquired or idiopathic) on self-reported depression, anxiety, fatigue, cognitive deficits, and ataxia symptom severity. Comparisons were also made between the ataxia sample as a whole and a neurologically healthy control group.

Method

Responses were collected using a cross-sectional online survey to recruit a national UK sample of people with ataxia.

Results

The study recruited 110 participants with ataxia (hereditary = 51, acquired = 16, idiopathic = 43) and 32 healthy controls. No significant differences were found across study variables for different causes of ataxia. However, participants with ataxia did report significantly higher levels of depression, anxiety, fatigue, cognitive deficits, and ataxia symptom severity compared to healthy controls.

Conclusion

This study found that participants with ataxia self-reported increased non-motor symptoms compared to healthy controls, which was a generally homogenous experience across different causes of ataxia. There was also considerable comorbidity of symptoms which requires further exploration. This study highlights the need for early assessment and intervention to address these non-motor symptoms in ataxia populations.
The Temple of Our Soul
Authors: Anonymous
Published: May 2024

The Temple of our Soul is one of the most attractive spiritual texts of the late Middle Ages and early modern period. Written by an anonymous woman, who was also the author of influential The Evangelical Pearl, this masterpiece offers insights into the mystical aspects of Christianity that were widespread in Rhineland and the Low Countries. For political, socio-economic, and geographical reasons, spiritual writings from the Low Countries were highly influential in France, England, and Spain. Language barriers, however, have made the original texts inaccessible to many scholars and students. This bilingual edition offers the first English translation The Temple of our Soul together with the original Dutch text. This edition includes an introduction that provides insights into the text's key themes and the social context in which it was written. In addition to students of medieval mysticism, it will also be of interest to scholars of late medieval and early modern vernacular literature and feminist theology.
Reclaiming the Cultural Politics of Teaching and Learning
Authors: Vass Greg
Published: May 2024

Despite often being associated with anti-establishment, irreverent, and a do-it yourself (DIY) rejection of dominant culture, less considered may the collaborative, communal and curative threads of punk thinking, being and doing. From the outset, punk offered critiques and alternative ways of conceptualizing a world and ways of worlding, that aren't as harmful and constraining as those encountered by many in the dominant milieu of life. This monograph is focused on how and why punk can productively contribute to efforts that are responding to the influences of dominant culture in education, such as the effects of standardization, heightened accountabilities, and 'gap talk'. For this Element, punk can be thought of as social practices that generate cultural resources that can be utilized to critique dominant culture. Hence, this Element aims to make the case that punk sensibilities offer educators opportunities to reclaim the cultural politics of teaching and learning.
Human Perfection, Transfiguration and Christian Ethics
Authors: Gill Robin
Published: May 2024

Most people would agree that human perfection is unattainable. Indeed, theologians have typically expressed ambivalence about the possibility of human perfection. Yet, paradoxically, depictions of human perfection are widespread. In this volume, Robin Gill offers an interdisciplinary study of human perfection in contemporary secular culture. He demonstrates that the language of perfection is present in church memorials, popular depictions of sport, food, music and art, liturgy, and philosophy. He contrasts these examples with the socio-psychological concept of 'maladaptive perfectionism', using commercial cosmetic surgery as an example, as well as the 'adaptive perfectionism' suggested in the lives of Henry Holland, Paul Farmer, and, more ambivalently, Ludwig Wittgenstein. Gill then provides an in-depth analysis of New Testament and Septuagint usage of teleios and theological debates about the human perfection of Jesus. He argues that the Synoptic accounts of the Transfiguration offer a template for a Christian understanding of perfection that has important ecumenical implications within social ethics.
Black Woman on Board
Authors: Nicol Donna J.
Published: May 2024

Offers a rare view inside the university boardroom, to show the vital role Black women educational leaders played in ensuring access and equity for all.
Autobiographical Recollections of Charles-Marie Widor
Authors: Smith Rollin
Published: May 2024

The last of the Romantics, Widor narrated his recollections in 1936, bringing to life his diverse experiences from the time of Louis Philippe to the cusp of World War II.
Religious Conflict at Canterbury Cathedral in the Late Twelfth Century
Authors: Barnaby James
Published: May 2024

Documents a long-running dispute between the archbishops and monks of Canterbury throughout the 1180s and 1190s.
Five steps to high quality antimicrobial stewardship research
Authors: Langford Bradley J. , Bailey Pamela , Livorsi Daniel J. , Brown Kevin A. , Advani Sonali D. , Dodds Ashley Elizabeth , Bearman Gonzalo , Nori Priya
Published: May 2024

The escalating threat of antimicrobial resistance (AMR) necessitates impactful, reproducible, and scalable antimicrobial stewardship strategies. This review addresses the critical need to enhance the quality of antimicrobial stewardship intervention research. We propose five considerations for authors planning and evaluating antimicrobial stewardship initiatives. Antimicrobial stewards should consider the following mnemonic ABCDE: (A) plan Ahead using implementation science; (B) Be clear and thoroughly describe the intervention by using the TidIER checklist; (C) Use a Checklist to comprehensively report study components; (D) Select a study Design carefully; and (E) Assess Effectiveness and implementation by selecting meaningful outcomes. Incorporating these recommendations will help strengthen the evidence base of antimicrobial stewardship literature and support optimal implementation of strategies to mitigate AMR.
POUR-EL’S LANDSCAPE
Authors: KURAHASHI TAISHI , VISSER ALBERT
Published: May 2024

We study the effective versions of several notions related to incompleteness, undecidability, and inseparability along the lines of Pour-El’s insights. Firstly, we strengthen Pour-El’s theorem on the equivalence between effective essential incompleteness and effective inseparability. Secondly, we compare the notions obtained by restricting that of effective essential incompleteness to intensional finite extensions and extensional finite extensions. Finally, we study the combination of effectiveness and hereditariness, and prove an adapted version of Pour-El’s result for this combination.
Comparability and Value in Comic-to-Film Adaptations
Authors: Pratt Henry John
Published: May 2024

In this article, I argue, adverting to critical practices, that film adaptations are comparable with the comics that serve as their sources. The possibility of comparison presumes the existence of covering values according to which these comparisons are made. I raise four groupings of covering values for comics—narrative, pictorial, historical, and referential—and show how they apply to film adaptations as well, and argue that a fifth kind of value, fidelity, is relevant to comparisons of source comics to film adaptations. I close with a discussion of different types of fidelity that might be brought to bear in evaluation.
An ethical leadership assessment center pilot: Assessing and developing moral person and moral manager dimensions
Authors: d’Amato Alexis , Murugavel Vignesh , Medeiros Kelsey , Watts Logan L.
Published: May 2024

Ethical leaders are those who exemplify moral behavior personally, as well as those who facilitate follower ethical behavior. Although recent attention has been given to the ethical leadership construct, there remains a lack of innovation regarding the assessment and development of ethical leaders in organizations. To address these issues, a pilot study was conducted to examine the convergent validity of an ethical leadership assessment center, as well as the efficacy of using assessment center feedback to foster ethical leadership. Assessees completed a battery of pre tests, a virtual business simulation with a novel exercise, and a set of post tests. Half of the assessees were randomly assigned to a feedback condition, whereas the other half did not receive feedback until after the post tests were completed. Due to low statistical power, quantitative results were inconclusive. Nevertheless, qualitative insights were gained that point to implications for validating assessment center methodologies when assessing and developing ethical leadership.