bluuebunny/crossref_metadata_2025 huggingface dataset:
Disability exclusion and rights: The life story of Alice Jamieson
Authors: Lynch Allison
Published: July 2023

There is a commonly held belief that fear of disability by society is the reason for segregation of the disabled. Although acknowledging the validity of such a belief, this paper disputes this claim as it pertains to sufferers of mental illness. Specifically it explores one woman’s development of dissociative identity disorder as a result of years of incestuous abuse. Alice Jamieson developed multiple personalities in order to survive her horrendous childhood, which ultimately caused her to live a life of segregation and social exclusion. Alice did however; experience the enabling effects of positive, supportive relationships on rare occasions throughout her childhood (with her grandfather) and her adult life (with a work colleague). The telling of her story bought Alice a powerful sense of healing and has helped raise awareness of childhood sexual abuse and its devastating consequences.
Reflections on the value of a supportive ‘village’ culture for parents, carers, and families: Findings from a community survey
Authors: Lush Brett , Boddy Jennifer
Published: July 2023

In communities where members actively engage with others, perceive their neighbourhood to be safe, and have a positive sense of belonging, children's safety, health, and wellbeing are enhanced. However, over the last few decades, there have been extensive socioeconomic and demographic changes in Australia, which have eroded family and neighbourhood support networks. .We surveyed local residents about whether they viewed their community as a supportive environment, with a ‘village’ culture, that is, a place where they had developed positive personal networks. Fifty eight parents and carers from three early childhood and education centres identified their observations, perceptions, and experiences about the community environment in which they were raising their children. The community was generally described as a good place to raise children by most residents, but for a small proportion, exclusion and stress were problematic. This small group had limited opportunity or capacity to engage in the community. Informal connections were the most common source of support, but up to 40 percent of the parents were not always able to access supports. Formal services were underutilised, particularly given the level of stress and isolation in the community. In this paper, the authors suggest measures to help communities and family support services to better understand community cohesion and access meaningful support.
Homelessness in Queensland mining communities: A down payment on Australia’s wealth or inevitable product of a neo-liberalist society’s response to the cyclical fortunes of mining
Authors: Warren Shane , McDonald Donna , McAuliffe Donna
Published: July 2023

The mining boom in Australia of the first decade of the Twenty-First Century yielded prosperity for many Australians living in rural, regional and urban locations. This sense of prosperity was grounded in the widely reported experiences of people usually employed directly through the mining industry, or related industry, on high incomes, able to afford regular overseas holidays, ownership of multiple properties, material possessions and other hallmarks of an affluent lifestyle. However, less attention was given to vulnerable and homeless Australians in mining communities who did not benefit at all during the mining boom. In fact what evidence does exist indicates their disadvantage was further compounded through the high cost of housing. It is now widely accepted that the mining industry has been in a state of downturn over the last three years and this has served to highlight the social issues facing mining communities now and into the future. What is to be learnt from the decade long mining boom? Specifically this paper critiques the evidence, research literature and theories about urban-centric homelessness and assesses their relevance to homelessness in mining communities. This paper argues that the dynamics of homelessness in mining communities challenge existing homelessness theory and knowledge and argues that further evidence is needed to properly understand structural causes of homelessness in mining communities and to guide policy responses that may help prevent homelessness or otherwise assist homeless people access housing and support services. Identifying the mining boom and mining downturn cycle will be explored. Finally this paper outlines the case for further research to improve policy and planning responses to address homelessness in these communities taking into account planning requirements to address the mining boom and down turn cycle.
Oxcarbazepine: Preformulation Studies of Authoritative Part of Formulation Design
Authors: Sharma Neha , Ahirwar Priyanka
Published: July 2023

Preformulation research is a stage that is started before the novel molecule is seeded. In a larger sense, it connects with studies of a molecule's physical, chemical, analytical, and medicinal properties and offers ideas about appropriate modifications that could be made to improve performance. The analysis of preformulation characteristics can contribute to the development of pharmaceutical formulations that are efficient, safe, dependable, and stable. Oxcarbazepine is an antiepileptic drug. It controls seizures or fits by declining the abnormal and excessive activity of the nerve cells in the brain.
Outer Space Commercial Mining: Ownership Rights and Contemporary Legal Issues
Authors: Akpambang Enobong Mbang , Akanle Abayomi Oluwaseun
Published: July 2023

Prior to the beginning of the Cold War, exploration of outer space by explorers was majorly for scientific discoveries of new planets. But as time went by, governments and private entities began to explore further for natural resources that could be beneficial to the existence of man on earth. Such minerals that could be found in asteroids include iron, iridium, nickel, magnesium, gold, platinum, and palladium, among others. Although every nation of the world is believed to have equal right to outer space and the resources discovered therein, the commercialisation of space mining activities have seemingly restricted the control of these resources to world leading governments such as, the United State, China, Russia, Japan, France and some private enterprises who have the financial power for such activities. The goal of the article was to examine commercialisation, property rights and contemporary legal issues concerning outer space mining. Can private or non-governmental entities operate in the outer space without governmental authorisation and continuing supervision? How best could ensuing space mining disputes and environmental concerns be addressed? Doctrinal research method was adopted for this study to discuss fundamental issues and resolve questions raised by the article. This entailed the examination of available literature in the area plus existing international and domestic laws regulating outer space mining activities in order to give in-depth analysis of the subject matter and to support the position reached in the article. In concluding the article, the authors proffered some suggestions on the identified contemporary issues.
Efek Moderasi Gender Atas Pengaruh Profitabiltas dan Peluang Pertumbuhan Terhadap Nilai Perusahaan
Authors: Ramadhan Muhammad Fadly , Gumanti Tatang Ary , Gamaliel Hendrik
Published: July 2023

Meningkatkan nilai perusahaan merupakan salah satu tujuan bagi perusahaan. Penelitian terdahulu melihat adanya pengaruh profitabilitas dan peluang pertumbuhan terhadap nilai perusahaan. Berpijak pada rekomendasi dari OECD yang mendorong perusahaan untuk meningkatkan peran serta Wanita dalam pengambilan keputusan, penelitian ini menguji pengaruh diversifikasi gender terhadap nilai perusahaan dan efek moderasi gender atas pengaruh profitabilitas dan peluang pertumbuhan terhadap nilai perusahaan. Sampel penelitian terdiri dari 100 tahun perusahaan yang terdaftar pada index LQ-45 di Bursa Efek Indonesia. Sedangkan periode analisis mencakup tahun 2017 sampai dengan tahun 2020. Pengujian hipotesis menggunakan regresi data panel dan Moderated Regression Analysis (MRA). Hasil penelitian menunjukkan bahwa diversifikasi gender berperan sebagai quasi moderator dan memberikan efek moderasi baik terhadap pengaruh profitabilitas terhadap nilai perusahaan maupun pengaruh peluang pertumbuhan terhadap nilai perusahaan.
Skoring Kerusakan Hati Tikus Jantan (Ratus norvegicus Berkenhout.) setelah Pemberian Ekstrak etanol Daun Supan-supan (Neptunia plena Lour.)
Authors: Pribadi Anjar , Ariska Sihaloho Arta , Rusmiati
Published: July 2023

The supan-supan plant (Neptunia plena Lour.) is empirically trusted by the people of Pal Batu Village, Paminggir District, Hulu Sungai Utara as a traditional medicine to increase libido. The safety value of the use of supplementary soil is still unknown, so in this study it is necessary to study how the safety of the use of supplementary plants against the liver is needed. This research was conducted by Completely Randomized Series (CRD) involving 24 male rats which were divided into 4 groups. The liver organs were then made preparations and stained with HE and scored. The results obtained were significantly different from the control with a p<0.05.
Determinan Capaian Standar Pelayanan Minimal (SPM) pada Pelayanan Kesehatan Orang Beresiko Terkena HIV dengan Pendekatan Malcolm Baldrige di Puskesmas Kota Depok Tahun 2022
Authors: Asyulia Rora , Priyo Hastono Sutanto
Published: July 2023

Quantitative research with a cross-sectional design (Cross Sectional) will examine the achievements of health service programs for people at risk of getting HIV using the Malcolm Baldrige approach at the Depok City Health Center. The purpose of this study was to determine the performance of the health service program for people at risk of getting HIV using the Malcolm Baldrige approach. The population of this study were all Community Health Centers in Depok City, totaling 38 Health Centers. The research instrument used questionnaires and interviews which were made based on standard references from Malcolm Baldrige's criteria which had been translated into Indonesian by previous researchers and adapted to the research objectives. There are 6 independent variables, namely leadership, strategic planning, focus on customers, measurement analysis and knowledge management, focus on workforce and process management, while the dependent variable is the achievement of MSS in health services for people at risk of getting HIV. Data analysis used univariate data analysis to look at the frequency distribution of performance outcomes, bivariate data analysis looked at the relationship between 6 (six) Malcolm Baldrige criteria and the performance outcomes of the Health Service Program for people at risk of getting HIV at the Depok City Health Center and multivariate analysis to find the most dominant influencing factor achievement of SPM HIV. The majority of research results fall into the category of unfavorable leadership (53.07%), strategic planning (46.21%) focus on customers (43.84%), measurement, analysis and knowledge management (44.21%), workforce (47 ,85%) and process management (47,49%) . Paldal multivalial analysis value R = 0.749 on valrialbel X (leadership valrial in customer focus) with Y valrial (SPM HIV skill) shows a high quality relationship in positive, whereas in return the leadership valrial in focus on customer malcal halsil performance in SPM Alkaline HIV is increasingly increasing . The value of the coefficient of determination (R squalre) shows a value of 0.561, which is obtained from the regression model obtained in terms of 56.1%, the valrial rating is dependent on the calculation of the SPM HIV with the Focus on the failure which has the greatest influence on the performance evaluation of the MSS HIV (48.5%).
Tanggung Jawab Negara dalam Memberikan Perlindungan Hukum terhadap Anak Penyalahguna Narkotika
Authors: Ardy Sengkey Hardian , Michael Tomy
Published: July 2023

In the case of children who have abused narcotics, they are not only considered as perpetrators of crimes but as victims of the crime itself. The Child Protection Act also stipulates that child victims of narcotics abuse receive special protection. The fundamental weakness in law enforcement is that the rights of children who are victims of narcotics abuse are often neglected because they do not receive adequate regulation. Legal protection for children who abuse narcotics so far has only reached the procedural level and has not achieved substantial justice. Law enforcement for children who abuse narcotics is solely aimed at imposing sanctions on the perpetrators of crimes without considering aspects of the losses suffered by children who abuse narcotics. The imposition of sanctions is solely for revenge against the perpetrator without recovering the losses suffered by the child himself. Several laws in Indonesia have actually outlined several things that are the rights of children who are victims of narcotics abuse, but these rights are only regulated normatively and contain the rights of victims that are different from one another, both in terms of implementation and implementation, one of which is related to medical and social rehabilitation, as well as compensation (restitution). In order to provide an articulation of the meaning of the form of state responsibility in providing legal protection for child victims of narcotics abuse, it is necessary to reconstruct Law Number 11 of 2012 concerning the Juvenile Criminal Justice System, by adding a clause regarding the amount of rehabilitation value and stipulating restitution as an additional punishment. for perpetrators of narcotics dealers against children into the Government Regulation of the Republic of Indonesia Number 43 concerning the Implementation of Restitution for Children Who Become Victims of Crime.
Characterizing Senna Alata Fiber and Echinochloa Frumentacea Leaf Fiber: A Novel Approach for Composite Applications
Authors: N. Shalom
Published: July 2023

The characterization of natural fibres is used in the domain of materials science and engineering with the objective of generating new environmentally acceptable bio-composites. The purpose of this study is to create and characterize a bio-composite reinforced with Senna Alata fibre and Echinochloa frumentacea fiber. This study analyzes the mechanical, thermal, and morphological characteristics of the fibre. The physicochemical research indicated that the fibre has an excellent average density of 1270 kg/m3. In fact, Senna Alata Fiber (SAF) tensile strength ranges from 2300 to 5479 MPa and Echinochloa frumentacea leaf fiber -EFLFs tensile strength ranges from 204.32 14.25 MPa. As a result, the current study suggests that SAF and EFLF can be used as reinforcing materials with maximum specific characteristics as well as minimal environmental impact in the manufacturing of bio- composite.
Giving the Fourth Amendment Meaning: Creating an Adversarial Warrant Proceeding to Protect From Unreasonable Searches and Seizures
Authors: Mordechai-Strongin Ben
Published: July 2023

For at least the past 40 years, police and prosecutors have had free reign in conducting illegal searches and seizures nominally barred by the Fourth Amendment. The breadth of exceptions to the warrant requirement, the lax interpretation of probable cause, and especially the “good faith” doctrine announced in U.S. v. Leon have led to severe violations of privacy rights, trauma to those wrongly searched or seized, and a court system overburdened by police misconduct cases. Most scholars analyzing the issue agree that the rights guaranteed by the Fourth Amendment—to be free from unreasonable search and seizure—have been severely eroded or even eviscerated by the Supreme Court. Some suggest that in order to revitalize the Fourth Amendment, the United States should make it easier to secure civil damages after Fourth Amendment rights have been violated. Others have argued that the United States must guarantee stronger ex ante protections to uphold fundamental privacy rights before they are violated.

This Note argues that, while warrant requirements do need to be more stringent to safeguard Fourth Amendment rights, warrant requirements cannot on their own sufficiently protect such a sacred right. This Note proposes the adoption of adversarial warrant proceedings, designed to ensure police and prosecutors meet their probable cause burden and to ensure that any lies or sloppy investigative work are rooted out from a warrant application before a warrant is granted. False searches and arrests can be deeply traumatizing and have excruciating and long-term impacts. For the Fourth Amendment to have any meaningful affect, the People must have an advocate—a Warrants Counsel— fighting for their right to be free from unreasonable searches before that right is violated.

The Roberts Court’s destruction of the Fourth Amendment leaves little reason to expect protection from unreasonable search and seizure through litigation. Instead, Congress must create the Warrants Counsel program legislatively. Congress should look to the major success of the Federal Defenders program as a blueprint for zealous advocacy and protection of rights. A Warrants Counsel, like a public defender, would be a government paid attorney, present to argue against probable cause before a magistrate whenever police or prosecutors seek a warrant. Like the Sixth Amendment before the public defender system, the Fourth Amendment desperately needs some structure to give its language meaning; the Warrants Counsel system would counterbalance over-powered police and prosecutors in favor of the People.
Anticipation or avoidance: internal medicine resident experiences performing invasive bedside procedures
Authors: Louis Alyssa S , Lee Christie , Page Andrea V , Ginsburg Shiphra
Published: July 2023

Background: Internal Medicine (IM) residents are required to perform bedside procedures for diagnostic and therapeutic purposes. Residents’ experiences with procedures vary widely, for unclear reasons.
Objective: To explore IM residents’ experiences with performing bedside procedures and to identify barriers and facilitators to obtaining sufficient experience.
Methods: Using an inductive, thematic approach, we conducted five individual semi-structured interviews and one focus group with seven IM residents (12 residents in total) during the 2017-2018 academic year at a Canadian tertiary care centre. We used iterative, open-ended questions to elicit residents’ experiences, and barriers and facilitators, to performing bedside procedures. Transcripts were analyzed for themes using Braun and Clarke’s method. 
Results: We identified four themes 1) Patient-specific factors such as body habitus and procedure urgency; 2) Systems factors such as time constraints and accessibility of materials; 3) Faculty factors including availability to supervise, comfort level, and referral preferences, and 4) Resident-specific factors including preparation, prior experiences, and confidence. Some residents expressed procedure-related anxiety and avoidance.
Conclusion: Educational interventions aimed to improve procedural efficiency and ensure availability of supervisors may help facilitate residents to perform procedures, yet may not address procedure-related anxiety. Further study is required to understand better how procedure-averse residents can gain confidence to seek out procedures.
The Effect and Process Parameters During Conventional Drilling and Abrasive Water Jet Drilling
Authors: - Sai Srikanth Varanasi , - Lakshmi venkata Sai Praveen
Published: July 2023

In Drilling is the important machining process in manufacturing industry. Optimization of process parameters during drilling operation has been key research in recent times. Over the years, many methods were proposed for optimization of process parameters during drilling which are aimed to get good surface finish, good quality hole, good material removal rate etc. In this regard the present work focuses on comparative study on effect of process parameters during conventional drilling and Abrasive water jet drilling. In this particular work different process parameters such as Material, thickness, speed is taken. Experiments are conducted according to L9 Orthogonal array both on conventional and Abrasive water jet drilling. The final results of Material Removal Rate and Hole taper are subjected to statistical analysis in Minitab19 software and Regression Analysis whose results are analyzed and compared to give conclusions.
A Comparative Study of Consumption of Animal Milk and Plant Based Milk among Young Adults
Authors: - Tina Mittal , - Sravani Chiruvella
Published: July 2023

Milk is a nutrient dense food that is recognized as nature's most complete meal which continues to play a significant role in people's diets all across the world. The most commonly consumed animal milks are cow's milk, goat's milk, and buffalo's milk however, people are becoming more aware of the darker aspects of dairy, such as the cruelty it inflicts on animals, the environmental damage, and the health risks. As a result of these factors, plant milk consumption has increased in recent years. These beverages are preferred by those who have a cow's milk allergy, lactose intolerance, environmental concerns, hypercholesterolemia, calorie concerns, or are adopting new lifestyles such as veganism. Even with the growing economic success of plant milk beverages, no research has been done to compare the consumer’s perception, awareness, and health issues of animal milk to those of plant milk among young adults in India, and therefore, further investigation is needed. Because young adults are still growing, providing accurate milk information will encourage them to increase their milk consumption. As a result, the focus of this study will be on Indian young adults’ opinions, awareness, and health concerns surrounding animal and plant milk.
Investigating the Role of the Cultivated Banana Value Chain as a Potential Source of Sustainable Income for Local Communities in Lao PDR
Authors: Wongpit Piya , Inthakesone Bounmy , Sisengnam Keuangkham , Syphoxay Pakaiphone
Published: July 2023

Cultivated bananas have gained attention due to the environmental and social impacts of Cavendish bananas in the northern part of Laos. This study investigated the value chain of cultivated bananas and its implications for sustainable income generation. Basic statistical analysis was used to assess the value added by cultivated bananas, while stakeholder analysis and value chain mapping were used to identify key actors and relationships. The determinant of commercialization is observed through the regression model and the impact of commercialization is investigated through the second stage regression. The study found that the banana value chain in Laos is driven by the export market. Farmers generate the highest profit, but they receive the lowest distribution of value-added. Banana commercialization can significantly increase the income of farmers, but the impact is not equal for all farmers. Bananas are a sustainable income source for households in Laos, and they have the potential to be promoted in high-value markets if the farmers create new products and improve skills of management, marketing, and finance with the support from government policies.
Penerapan Pantun Kenangan Perpisahan dalam Penilaian Lisan sebagai Kesan Pembelajaran Teradun
Authors: Sew Jyh Wee
Published: July 2023

Perbincangan tentang pengajaran pantun Melayu dengan menggunakan pedagogi inovatif ini menuju ke arah pendidikan bahasa Melayu yang progresif. Demi kelestarian pantun Melayu, satu siri pengkaedahan diusulkan sebagai teknik yang dapat memberi kefahaman asas kepada pelajar bahasa asing tentang pantun empat baris sehingga memperlihatkan kesannya, iaitu kemahiran berfikir aras tinggi. Pendekatan pedagogi yang dimaksudkan membolehkan dua orang pelajar bukan penutur asli dalam pengkhususan bahasa Melayu sebagai bahasa asing di Universiti Nasional Singapura (NUS) menghasilkan serangkap pantun empat baris secara sukarela sebagai sebahagian daripada rakaman lisan pembelajaran dalam talian melalui Zoom. Maklum balas pelajar ini dianggap sebagai kesan pembelajaran teradun yang mewajarkan pemerhatian teliti dalam pengajaran bahasa Melayu sebagai bahasa asing. Secara deduktif, perhatian ditumpukan pada seperangkat pedagogi dalam kuliah kemahiran mencipta pantun. Terdapat tiga set pengajaran yang disediakan dalam kuliah pelengkap. Pertama, pengajaran nama monyet yang berlainan kepada pelajar untuk memperkembang kosa kata fauna dalam binaan pembayang maksud pantun dan mempertingkatkan penguasaan kata nama khas Melayu. Kedua, pengajaran onomatopoeia bahasa Melayu sebagai elemen yang bersesuaian dalam penciptaan pantun memupuk kesedaran pelajar tentang naluri bahasa Melayu. Ketiga, penggunaan klip video tentang pergaulan sosial yang memperlihatkan aksi berbalas pantun secara bersilih ganti meluaskan pandangan pelajar terhadap amalan berpantun yang masih dihargai dan dituturkan oleh penutur bahasa Melayu dalam kehidupan seharian. Rangkaian pedagogi bahasa yang digalurkan mampu memupuk kemahiran mereka untuk mencipta pantun dan disyorkan sebagai satu kaedah pengajaran teradun yang berkesan.
Pemanfaatan Media dan Teknologi Digital Dalam Mengatasi Masalah Pembelajaran Dimasa Pandemi
Authors: Arikarani Yesi , Amirudin Muhammad Faizul
Published: July 2023

Digital or online learning is one of the right solutions in today's learning, the transformation from face to face (conventional) to online learning, all of which require understanding, skills and familiarity with online learning. Many problems were found in the use of media and digital technology applied in the first learning process, learning saturation, second, not following the learning process well. Third, not disciplined to do the task. This study aims to analyze various study concepts regarding the use of digital learning media and technology by analyzing using a literature review method that refers to theoretical studies and other references related to values, socio-culture and norms that develop in the social situation under study. The results of the analysis of the use of media and learning technology in overcoming problems during the pandemic are knowledge about the implementation of digital learning, blended learning models, online learning strategies, the accuracy of choosing LMS applications in digital learning and providing a contribution and prospect to online learning which is considered quite good and significantly improved in current learning.
Implementasi Gerakan Literasi Digital Keagamaan Di Era Pandemi Covid-19 SMAN 1 Petarukan
Authors: Muftiroh Ira , Atqia Wirani
Published: July 2023

Literacy is a skill to manage information properly. This research aims to describe how the implementation and benefits of the digital religious literacy movement in the pandemic era of SMAN 1 Petarukan. the method used is the method of observation, interviews and documentation. The results of the study can be concluded, 1) Implementation of the digital religious literacy movement in the pandemic era of SMAN 1 Petarukan, using google and youtube links shared by the homeroom teacher. The literacy method used is lecture and summarizing. homeroom teacher is given the authority to use one method. At SMAN 1 Petarukan the hours to carry out the religious digital literacy movement start from the 0th hour to the 1st hour. In reading literacy material for 15 minutes after that the remaining time is used for deepening based on the method used. 2) The benefits of the religious digital literacy movement in this pandemic era allow students to increase religious insight, increase students' faith, improve spiritual attitudes.
Pemberdayaan Dan Pendidikan Warga Ex Lokalisasi di Kota Lubuklinggau
Authors: Helandri Joni , Sari Juliah Indah , Hasani Muhammad , Saputra Muhammad Leo , Indika Puspa , Munawaroh Serli
Published: July 2023

This research aims to review the efforts to empower ex-localization communities with certain approaches. In this study using descriptive qualitative research, the data sources are in the form of interviews, documentation, the data obtained from the research is analyzed and produced. One of the efforts made so that ex-localization residents can live independently is carried out by coaching through religious approaches such as deepening religious knowledge, education, and an approach to economic empowerment by training and making ex-localization residents ready to work to be able to compete in accordance with the demands of the community
Kontrol Guru Pendidikan Agama Islam Mengatasi Perilaku Penyimpangan Akhlak Siswa Di SMP Negeri Muara Beliti
Authors: Arikarani Yesi , Yanti Hamida Juni , Ngimadudin Ngimadudin , Mukmin Taufik
Published: July 2023

Today's youth associations are very worrying due to the development of modernization currents and the depletion of one's morals and faith. Moral impoverishment as a contributing factor to the occurrence of deviant behavior. This research is to deal with the problem of school deviant behavior by directing the integration of the formulation of social aspects subject matter with Islamic religious education. This research uses qualitative research methods (field research), data collection techniques, data analysis techniques and triangulation. The findings of this study that the control of Islamic religious education teachers on the behavior of deviant morals of students at the first Muara Beliti State Junior High School, teachers provide solutions in the form of advice, motivation, religious habituation such as carrying out zuhur congregational prayers, listening to lectures and kultums. Second, efforts to prevent teachers in overcoming problems through repressive and curative prevention. Third. Factors that cause the behavior of student moral storage are family, school, and community. Play an important role in realizing good behavior based on the role of parents, teachers, and the community.
Phase I/II study of c-MET inhibitor (DE605) combined with sorafenib in patients with advanced hepatocellular carcinoma
Authors: Karayel Bahar , Durgun Sena , Öcalgiray Orhan
Published: July 2023

Background: DE605 is a c-MET inhibitor that can be taken orally. Sorafenib is the only treatment that has been proven to increase overall survival rates in patients with advanced hepatocellular carcinoma (HCC). However, the effectiveness of sorafenib in a clinical setting is limited. By targeting multiple signaling pathways through combination therapy, patient outcomes may improve. This study aimed to establish the maximum tolerated dose (MTD) of DE605 when administered alongside sorafenib and to assess the safety and efficacy of this combination in treating patients with advanced HCC.

Patients and methods: Patients with advanced HCC received treatment that combined increasing doses of DE605 and sorafenib. The first phase of the study aimed to establish the MTD of this combination. In the second phase, patients were treated with the MTD to assess the safety and effectiveness of the treatment.

Results: In the first phase of the study, 27 patients were treated with sorafenib and increasing doses of DE605. In the second phase, 32 patients were enrolled. The MTD was determined to be 240 mg of DE605 once daily (QD) in combination with 400 mg of sorafenib twice daily (BID). Of the patients treated with the MTD, 9.4% had a partial response, 65.6% had stable disease, and 25% had progressive disease. The median time to progression was 2.5 months and the median overall survival was 11.6 months.

Conclusion: The combination of 240 mg of DE605 QD and the standard dose of 400 mg of sorafenib BID showed significant clinical effectiveness in treating patients with advanced HCC. The early indications of antitumor activity suggest that further development of this combination therapy may be warranted.
Combinatorial Gray Codes — an Updated Survey
Authors: Mütze Torsten
Published: July 2023

A combinatorial Gray code for a class of objects is a listing that contains each object from the class exactly once such that any two consecutive objects in the list differ only by a `small change'. Such listings are known for many different combinatorial objects, including bitstrings, combinations, permutations, partitions, triangulations, but also for objects defined with respect to a fixed graph, such as spanning trees, perfect matchings or vertex colorings. This survey provides a comprehensive picture of the state-of-the-art of the research on combinatorial Gray codes. In particular, it gives an update on Savage's influential survey [C. D. Savage. A survey of combinatorial Gray codes. SIAM Rev., 39(4):605--629, 1997.], incorporating many more recent developments. We also elaborate on the connections to closely related problems in graph theory, algebra, order theory, geometry and algorithms, which embeds this research area into a broader context. Lastly, we collect and propose a number of challenging research problems, thus stimulating new research endeavors.
Rowmotion on 321-Avoiding Permutations
Authors: Adenbaum Ben , Elizalde Sergi
Published: July 2023

We give a natural definition of rowmotion for $321$-avoiding permutations, by translating, through bijections involving Dyck paths and the Lalanne--Kreweras involution, the analogous notion for antichains of the positive root poset of type $A$. We prove that some permutation statistics, such as the number of fixed points, are homomesic under rowmotion, meaning that they have a constant average over its orbits.

Our setting also provides a more natural description of the celebrated Armstrong--Stump--Thomas equivariant bijection between antichains and non-crossing matchings in types $A$ and $B$, by showing that it is equivalent to the Robinson--Schensted--Knuth correspondence on $321$-avoiding permutations permutations.
Design Simulation of Micro-Grid Hybrid Solar Power Plant as a Power Supply
Authors: Tirta Wijata Marcel Bonifacio , Anak Agung Adhi Suryawan  , Ketut Astawa  , I Gusti Ketut Sukadana  , I Made Parwata
Published: July 2023

PLTS has enormous potential in Indonesia, especially in Java-Bali, which accounts for 70% of Indonesia's electricity needs. In this study, a simulation of the PLTS system design was carried out using a hybrid microgrid as a power supply using PVsyst software to simulate PLTS performance. Power load requirements are adjusted to the specifications of electric vehicles. Meteonorm meteorological data were compared with field data to adjust for data variability. In the design simulation, there are three different slope angle scenarios, namely 10º, 13º, and 15º. The effective surface area for installing PLTS on an unmeasured roof is 35 m x 14 m (490 m2), so the number of modules that can be installed will be adjusted to the roof area. The PLTS system is capable of producing 169.3 MWh of power per year with an optimal tilt angle of 13º which has specific production of 1726 kWh/kWp/year and a performance ratio of 78.63%. PLTS is able to supply the power needs of 103 units of electric vehicles every day.
Family experiences of engagement in inclusive childcare programs for toddlers
Authors: Lieb Julianna , Classen Audra , Wright Lindsay , Filce Hollie
Published: July 2023

Previous research has explored family engagement experiences and practices in childcare programs. The purpose of this study was to explore family members’ experiences related to their engagement in decision-making processes across various inclusive, toddler childcare programs. Five early educators and eight parents participated in the study. Four parents had a child with a diagnosed disability or developmental delays, were at-risk for developmental delays, and/or received speech, occupational, or physical therapy. Eligible early educators participating in the study taught toddlers (18 to 30 months) in a private, faith-based, or university childcare program. A semi-structured interview style was used to collect family participant responses. The early educators’ inclusive practice indicator rubric scores previously collected from the larger grant funded project were used to triangulate data. Through a phenomenological qualitative design, this study gained a better understanding of families’ decision-making experiences, facilitators and barriers that may impact family engagement, and opportunities early educators have provided or not provided to encourage family engagement in inclusive, toddler childcare programs.
Young children as citizens: Learning from practice in the early childhood setting
Authors: Ryder Gemma M. , van Krieken Robson Jennifer
Published: July 2023

This paper examines enactments of young children’s citizenship in early childhood settings in England, which is an under researched area, in this study young children are positioned as social actors, competent and capable of making decisions and enacting citizenship. Values, child rights and citizenship are interconnected and often inseparable in practice. A mixed methods multiple-case study was conducted in England across several early childhood settings in the private and independent sector. Our findings indicate that young children enact citizenship through micro acts embedded into their day-to-day activities; such acts are often spontaneous in response to events or interactions. These are often pro-social in nature comprised as behaviours such as helping or showing concern for others. Our findings give visibility to the distinctive ways in which young children may enact citizenship including, for example, physical expressions.
‘When the body speaks back’: Socialization of body-mind dualism in body memories of Cold War childhoods
Authors: Kašparová Irena , Scutaru Beatrice , Millei Zsuzsa
Published: July 2023

Studies focusing on East Central Europe have generously explored collective memory (lieux de mémoire, monuments, ceremonies) and nostalgia for a past regime, but rarely have they examined memories as carried in child bodies. In this paper, we analyze selected Cold War childhood memories to explore events in which children’s bodies seemingly act out of control. As a part of socialization, children are taught to consciously control their bodies to fit in the societies they have been born to. With learning to control the body, children also learn that bodies are separate from their minds and that their minds can govern and regiment their body. However, bodies also slip up, avert, or simply remain unaffected by these attempts, in a way ‘speaking back’ to regulating forces, thus troubling the modernist assumption of the separation between the mind and body. The aim of the paper is to show the complexities and limits of socialist or any modern(ist) forms of socialization in which the concerted efforts of the mind are mobilized to govern the body. Moreover, the discussion of body memory and the highlighted mechanisms of how socialization efforts create bodily memories adds to our understanding of the effects of pedagogical intentions in education.
Hubungan Kecemasan Dan Beban Kerja Dengan Kualitas Tidur Perawat Di Ruang Rawat Inap Rumah Sakit Daerah Mangusada Badung
Authors: Wulandari Sarah Kartika , Swarjana I Ketut , Indrayanthi Putu Ayu Mita
Published: July 2023

Abstrak
Kualitas tidur yang rendah pada petugas kesehatan menjadi kendala dalam melakukan suatu keselamatan kerja. Penilaian tentang faktor yang berkorelasi dengan kualitas tidur menjadi penting sebagai kontrol kualitas layanan perawatan. Kecemasan dan beban kerja banyak dialami oleh petugas kesehatan sebagai stressor kurang tidur. Mengidentifikasi hubungan kecemasan dengan kualitas tidur perawat di ruang rawat inap Rumah Sakit Daerah Mangusada Badung dan mengidentifikasi hubungan beban kerja dengan kualitas tidur perawat di ruang rawat inap Rumah Sakit Daerah Mangusada Badung. Desain penelitian menggunakan analitik korelasi dengan metode pendekatan cross-sectional. Sampel yang digunakan adalah 100 perawat dengan pengambilan sampel menggunakan total sampling. Data dikumpulkan dengan kuesioner online yang diolah menggunakan aplikasi SPSS. Uji korelasi yang digunakan adalah Uji Spearman Rho, yang menguji hubungan kualitas tidur dengan masing- masing variable lainnya. Hasil penelitian sebagian besar responden memiliki kualitas tidur baik sebanyak 73 orang (73%). Responden dengan kecemasan rendah sebanyak 51 orang (51%). Sebagian besar responden memiliki beban kerja ringan sebanyak 49 orang (49%). Hasil menunjukkan p-value <0.05 dengan kekuatan korelasi positif (r=0,305) dan hasil analisa data antara beban kerja dengan kualitas tidur perawat menunjukkan p-value >0.05 dengan kekuatan korelasi positif (r=0,183). Terdapat hubungan yang signifikan antara kecemasan dengan kualitas tidur perawat dan tidak ada hubungan yang signifikan antara beban kerja dengan kualitas tidur perawat di ruang rawat inap. Sehingga perawat perlu mengontrol kecemasan sehingga dapat mencapai kualitas tidur yang lebih baik.  
Kata Kunci : Kecemasan, Beban Kerja, Kualitas Tidur
BURNOUT PERAWAT DI INSTALASI BEDAH SENTRAL DAN ANESTESI RSUD BALI MANDARA
Authors: Wiguna Kadek Adi , Artana I Wayan , Pertiwi Dewi Si Putu Agung Ayu
Published: July 2023

Kamar operasi merupakan ruangan khusus dalam memberikan pelayanan yang berkualitas kepada pasien. Perawat yang bertugas di ruang operasi dituntut untuk memiliki pengetahuan, kemampuan dan konsentrasi yang tinggi dalam semua aspek perawatan perioperative. Stressor tinggi bisa terjadi dalam upaya penyelamatan pasien, mengerjakan rutinitas, ruang kerja yang sumpek, jumlah pasien yang banyak, dan harus bertindak cepat dalam menangani kebutuhan pasien. Akumulasi dari kelelahan kerja yang tidak ditangani dengan segera dapat berdampak terhadap kepuasan kerja dari perawat hingga penurunan produktivitas. Penelitian ini bertujuan untuk memahami terjadinya burnout perawat di Instalasi Bedah Sentral dan Anestesi RSUD Bali Mandara. Penelitian ini menggunakan metode kualitatif yang berparadigma interprediktif dengan pendekatan fenomenologi. Data dikumpulan dengan menggunakan indefth interview, studi dokumen dan lembar observasi. Data wawancara dianalisis dengan metode spreadly. Hasil analisis menunjukkan Burnout yang dimiliki perawat IBSA diakibatkan oleh adanya tuntutan pekerjaan yang didasari oleh tidak ada jeda istirahat, durante operasi panjang, serta penghargaan dan pekerjaan masih kurang sesuai. Burnout dapat memunculkan rasa lelah yang dalam penelitian ini disampaikan sebagai lelah fisik dan lelah psikologis. Manajemen di RSUD Bali Mandara diharapkan dapat membuat atau mengkaji standar jumlah pasien yang dilayani pada setiap sift jaga perawat.
Perbedaan Pengetahuan Dan Sikap Ibu Hamil Sebelum Dan Sesudah Diberikan Buku Saku Tentang Stunting Di Wilayah Puskesmas Sandai Kabupaten Ketapang
Authors: Dianna Dianna , Damayanti Dini Fitri , Purnamasari Melda
Published: July 2023

Abstrak
Gerakan 1000 Hari Pertama Kehidupan (1000 HPK) atau periode emas (golden periode) adalah periode yang dimulai sejak terjadinya konsepsi sampai anak berusia 2 tahun yang terdiri dari 270 hari selama kehamilan dan 730 hari kehidupan pertama sejak bayi dilahirkan. Stunting tidak hanya disebabkan oleh satu faktor tetapi disebabkan oleh banyak faktor yang saling berhubungan satu dengan lain. Bayi dan balita merupakan kelompok yang memiliki prevalensi tinggi terhadap kejadian stunting di Indonesia. Diantara faktor langsung yaitu asupan makanan dan penyakit infeksi serta faktor tidak langsung yakni pola asuh ibu, pengetahuan gizi, pendidikan orang tua, pendapatan orang tua, distribusi makanan. Tujuan penelitian ini Untuk menganalisis perbedaaan pengetahuan dan sikap ibu hamil sebelum dan sesudah diberikan buku saku tentang stunting di wilayah kerja Puskesmas Sandai tahun 2020. Pada penelitian ini menggunakan rancangan one group pretest-posttest, dengan jumlah sampel 34 responden di wilayah kerja puskesmas Sandai. Pengumpulan data dilakukan dengan menggunakan kuisioner. berdasarkan uji statistik menunjukkan ada perbedaan pengetahuan yang signifikan sebelum diberikan buku saku tentang stunting dengan nilai median 5 dan nilai mean 29 (p<0,001)dan sesudah diberikan buku saku tentang stunting dengan nilai median 7 dan mean 34 ( p<0,001). media buku saku efektif untuk meningkatkan pengetahuan dan sikap ibu hamil tentang stunting.
 Kata Kunci: Pengetahuan, Sikap, Ibu Hamil Buku Saku, Stunting
Developing Students’ Interest In Learning English Through Digital Learning Platform
Authors: Prayudha S Joko
Published: July 2023

The implementation of technology in learning is a good way to help students  understand learning material. Through an interesting strategy, it will encourage students to always improve their understanding related to the implementation of learning. This study aims to obtain information about the English digital learning platform used by teachers to be able to attract students' interest and motivation in learning in EFL classes. The research was carried out qualitatively through a descriptive approach. The informants in this study were three English teachers who provided teaching through the use of digital learning platforms. Data were obtained through observation of learning and interviews with teaching implementers. Then, the data analyzed through data reduction, data display and conclusions. The results of the study show that teachers use various digital learning platforms in teaching English in order to encourage students to increase their motivation in learning English. The digital learning platforms that are used are very diverse, such as Padlet, Youtube, Canva, Kahoot, Quizizz and so on. The teacher also explained that the use of digital learning platforms was able to positively increase students' understanding in mastering learning material.
Teori-teori belajar bermunculan Teori Belajar Muncul Bersamaan Dengan Teori Belajar Kognitif
Authors: Aiwan Amjad , Kustati Martin , Sepriyanti Nana
Published: July 2023

Penelitian ini untuk mengungkap konsepsi Belajar dalam perspektif psikkologi dan Islam, belajar adalah kegiatan yang berproses dan merupakan unsur yang sangat fundamental dalam setiap kegiatan penyelenggaraan jenis dan jenjang pendidikan. Ini berarti bahwa berhasil atau gagalnya pencapaian tujuan pendidikan itu amat tergantung pada proses belajar yang dialami siswa, baik ketika ia berada di sekolah maupun dilingkungan rumah atau keluarganya sendiri. Teori belajar adalah teori yang pragmatik dan eklektik. Teori dengan sifat demikian ini hampir dipastikan tidak pernah mempunyai sifat ekstrim. Tidak ada teori belajar yang secara ekstrim memperhatikan siswa saja, guru saja, kurikulum saja, dan sebagainya. Penelitian ini pendekatannya melalui metode kualitatif dengan menggunakan data kepustakaan tanpa data statistik seperti pada metode kuantitatif, sehingga kegiataannya sering disebut sebagai library research. Secara umum hasil penelitian ini membuktikan bahwa pandangan kognitif melihat belajar sebagai sesuatu yang aktif. Mereka berinisiatif mencari pengalaman untuk belajar, mencari informasi untuk menyelesaikan masalah, mengatur kembali, dan mengorganisasi apa yang telah ada, sedangkan dalam perspektif Islam, belajar merupakan kewajiban bagi setiap muslim dalam rangka memperoleh ilmu dan pengetahuan sehingga dejarat kehidupannya meningkat. Hal ini dinyatakan dalam al-Qur’an surat al-Mujadilah ayat 11 Allah akan mengninggikan orang-orang yang beriman diantaramu dan orang-orang yang diberi ilmu pengetahuan beberapa derajat. Ilmu dalam hal ini tentu saja berupa pengetahuan yang relevan dengan tuntutan zaman dan bermanfaat bagi kehidupan manusia.