bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment
Authors: Shaw Julia C. , Dyson Rebecca M. , Palliser Hannah K. , Sixtus Ryan P. , Barnes Heather , Pavy Carlton L. , Crombie Gabrielle K. , Berry Mary J. , Hirst Jonathan J.
Published: April 2022

Background: Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable neonates. We have previously shown that the neurosteroid-analogue ganaxolone promotes white matter development and improves behavioural outcomes in male juvenile guinea pigs born preterm. Adverse side effects in this previous study necessitated this current follow-up dosing study, where a focus was placed upon physical wellbeing during the treatment administration and markers of neurodevelopment at the completion of the treatment period.

Methods: Time-mated guinea pigs delivered preterm (d62) by induction of labour or spontaneously at term (d69). Preterm pups were randomized to receive no treatment (Prem-CON) or ganaxolone at one of three doses [0.5 mg/kg ganaxolone (low dose; LOW-GNX), 1.0 mg/kg ganaxolone (mid dose; MID-GNX), or 2.5 mg/kg ganaxolone (high dose; HIGH-GNX) in vehicle (45% β-cyclodextrin)] daily until term equivalence age. Physical parameters including weight gain, ponderal index, supplemental feeding, and wellbeing (a score based on respiration, activity, and posture) were recorded throughout the preterm period. At term equivalence, brain tissue was collected, and analysis of hippocampal neurodevelopment was undertaken by immunohistochemistry and RT-PCR.

Results: Low and mid dose ganaxolone had some impacts on early weight gain, supplemental feeding, and wellbeing, whereas high dose ganaxolone significantly affected all physical parameters for multiple days during the postnatal period when compared to the preterm control neonates. Deficits in the preterm hippocampus were identified using neurodevelopmental markers including mRNA expression of oligodendrocyte lineage cells (CSPG4, MBP), neuronal growth (INA, VEGFA), and the GABAergic/glutamatergic system (SLC32A1, SLC1A2, GRIN1, GRIN2C, DLG4). These deficits were not affected by ganaxolone at the doses used at the equivalent of normal term.

Conclusion: This is the first study to investigate the effects of a range of doses of ganaxolone to improve preterm brain development. We found that of the three doses, only the highest dose of ganaxolone (2.5 mg/kg) impaired key indicators of physical health and wellbeing over extended periods of time. Whilst it may be too early to see improvements in markers of neurodevelopment, further long-term study utilising the lower doses are warranted to assess functional outcomes at ages when preterm birth associated behavioural disorders are observed.
Loneliness, Implicit-Self and Digital Literacy
Authors: Ko Dong Woo , Lee Ji-yeon , Kim Hyesuk
Published: April 2022

Digital literacy is becoming more important because of the skillset of functioning in online is becoming a necessary skill set in daily life. The purpose of this study was to examine the association between loneliness and digital literacy and the mediation effect of motivation in that association. Also, this study examined the moderating effect of mindset in the meditation effect of motivation in the association between loneliness and digital literacy. 287 respondents were recruited from online survey in United States. To investigate the direct effect of loneliness on digital literacy, the mediating effect of motivation, and the moderating of mindset on the mediating effect, this research employed a mediated moderation model. The findings of this research suggest that prevention-focused motivation mediated the effect of loneliness on digital literacy and the effect was moderated by a fixed mindset (as opposed to a growth mindset). The result of the study contributes to the literature by examining how loneliness could impede acquiring digital literacy through prevention-focused motivation and fixed mindset.
Knowing the Knowing. Non-dual Meditative Practice From an Enactive Perspective
Authors: Meling Daniel
Published: April 2022

Within a variety of contemplative traditions, non-dual-oriented practices were developed to evoke an experiential shift into a mode of experiencing in which the cognitive structures of self-other and subject–object subside. These practices serve to de-reify the enactment of an observing witness which is usually experienced as separate from the objects of awareness. While several contemplative traditions, such as Zen, Mahāmudrā, Dzogchen, and Advaita Vedanta emphasize the importance of such a non-dual insight for the cultivation of genuine wellbeing, only very few attempts in contemplative science have turned toward the study of non-dual-oriented practices. This article starts from a recently developed theoretical cognitive science framework that models the requirements of a temporary experiential shift into a mode of experiencing free from cognitive subject–object structure. This model inspired by the enactive approach contributes theoretically grounded hypotheses for the much-needed rigorous study of non-dual practices and non-dual experiences. To do so, three steps are taken: first, common elements of non-dual-oriented practices are outlined. Second, the main ideas of enactive cognitive science are presented including a principled theoretical model of what is required for a shift to a pure non-dual experience, that is, an experiential mode that is unbound by subject–object duality. Third, this synthesized theoretical model of the requirements for the recognition of the non-dual is then compared with a specific non-dual style of meditation practice, namely,Mahāmudrāpractice from Tibetan Buddhism. This third step represents a heuristic for evaluating the external coherence of the presented model. With this, the aim is to point toward a principled enactive view of non-dual meditative practice. In drawing the implications of the presented model, this article ends with an outlook toward next steps for further developing a research agenda that may fully address the concrete elements of non-dual practices.
Representation of Friendship and Aggressive Behavior in Primary School Children
Authors: Di Norcia Anna , Bombi Anna Silvia , Pinto Giuliana , Mascaro Chiara , Cannoni Eleonora
Published: April 2022

This study examines the representation of friendship during middle childhood and its impact on aggressive behavior. The literature shows that friendship is almost a “gym of social skills,” which, in turn, are protective factors against aggressive behavior; in this regard, the quality of friendship is especially important, but this quality becomes less and less accessible to direct observation as children grow older and spend most of their time in the externally regulated environment of primary school. To assess friendship quality requires allowing children to present their own perspective on the relationship, a goal that we have tackled through drawing. Children aged 6–11 years were individually asked to draw themselves and a close friend in two situations (i.e., relational wellbeing and relational distress) and to complete a 20-item scale of physical and verbal aggression. Data were analyzed with three main aims, namely, (1) to show if and how the representation of two core features of relationships (i.e., relatedness and individuality) changes according to the situation and/or according to the children’s gender; (2) to focus on the representation of distressing situations to verify if they coincide with forms of conflict and if they differ according to the children’s gender; and (3) to verify if the strength of indices of relatedness and individuality, both in situations of wellbeing and distress, predicts children’s tendency to enact aggressive behaviors. The results confirm that relatedness is the dominant feature of friendship, especially in the situation of wellbeing and when the situation becomes distressing. Conflict is not always present when children do not feel fine with their friends; boys and girls do not differ significantly in this regard, but they do differ in terms of the management of relatedness and individuality when problematic situations arise. In line with previous studies, sex is the main predictor of aggressive behavior with peers, with boys more at risk than girls; however, the capacity to relate with one’s own friend even in difficult times (in which boys are not inferior to girls) predicts lesser aggression with peers in general.
Academic Career Development of Chinese Returnees With Overseas Ph.D. Degrees: A Bioecological Development Perspective
Authors: Liu Dan , Xu Yuwei , Zhao Tongtong , Che Siqi
Published: April 2022

This study uses the bioecological model of human development to understand the academic career development of Chinese returnees with overseas Ph.D. degrees (CROPs). Focuses are placed on how CROPs engaged in this process through interactions with contexts, which lead to their differentiated and similar career development in Chinese higher education. Using a qualitative approach of semi-structured interviews with 31 CROPs, our findings reveal that CROPs’ academic career development is co-shaped by personal characteristics and multi-layered environmental contexts. The study highlights the dysfunctionality of Chinese higher education system in the context of China’s ambition to build First-class Universities and First-class Subjects (Double First-class), which constrains CROPs’ academic career development. The paper offers important implications for potential CROPs, policy, and future research studies.
Study on Influencing Factors of Construction Workers’ Unsafe Behavior Based on Text Mining
Authors: Li Ping , He Youshi , Li Zhengguang
Published: April 2022

The unsafe behavior of construction workers is the key cause of safety accidents. The accident investigation report contains rich experience and lessons, which can be used to prevent and reduce the occurrence of safety accidents. In order to draw lessons from the accident and realize knowledge sharing and reuse, this paper uses text mining technology to analyze the data of 500 construction accident investigation reports in Shenzhen, China. Firstly, a Latent Dirichlet Allocation (LDA) topic model is used to identify the unsafe behavior of construction workers and its influencing factors. Then, with the help of Social Network Analysis, the importance of influencing factors and the relationship between them are identified. The results show that weak safety awareness, operating regulations, supervision dereliction of duty, equipment resources, and inadequate supervision of the construction party are the key and important factors. It is also found that there are correlations between weak safety awareness and supervision dereliction of duty, between equipment resources and poor construction environment, between organization and coordination and inadequate supervision of the construction party, and between operating regulations and hidden dangers investigation. This study not only helps to improve the theoretical system in the field of construction workers’ unsafe behavior but also helps managers to find the key control direction of construction safety, so as to effectively curb unsafe behavior of construction workers and improve the level of safety management.
Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence
Authors: Yu Lu , Sun Yunming , Fang Qiongyan
Published: April 2022

Objective

To explore the curative effect of laparoscopic surgery combined with leuprorelin in the treatment of endometriosis with infertility and the related factors of recurrence after treatment.

Methods

A total of 158 patients with endometriosis and infertility were selected in our hospital from January 2019 to June 2020. Patients were randomly divided into the control group and the observation group, with 79 patients in each group. Patients in the control group was treated by laparoscopy surgery combined with dydrogesterone, while those in the observation group was treated with laparoscopic surgery combined with leuprorelin. The hormone levels, recurrence rate, pregnancy rate and adverse reaction of the two groups were compared. Combined with clinical and pathological information, the related factors of postoperative recurrence were analyzed.

Results

After treatment, the levels of luteinizing hormone, follicle-stimulating hormone and estradiol in the observation group were lower than those in the control group (P < 0.05). The recurrence rate at 12 months after operation in the observation group was lower than that in the control group, and the pregnancy rate was higher than that in the control group (P < 0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Preoperative dysmenorrhea was an independent risk factor for postoperative recurrence in patients with endometriosis, and postoperative pregnancy was a protective factor for postoperative recurrence in patients with endometriosis (P < 0.05).

Conclusion

Laparoscopy combined with leuprorelin in the treatment of endometriosis with infertility can improve hormone levels, increase the pregnancy rate and reduce the recurrence rate. Preoperative dysmenorrhea is an independent risk factor for postoperative recurrence, which should be quantified and included in the recurrence risk prediction model. Postoperative pregnancy can reduce the recurrence rate after operation, and patients with fertility requirements should be encouraged to make activ preparations for postoperative pregnancy.
Case Report: Esthesioneuroblastoma Involving the Optic Pathways
Authors: da Silva Vithor Ely B. , Buniatti Samuel R. , Costa Felipe D'Almeida , Torrecillas Mauricio R. , de Oliveira Jean G. , Rassi Marcio S.
Published: April 2022

Olfactory neuroblastoma, or esthesioneuroblastoma, is an uncommon malignant tumor originating from the neural crest that commonly occurs in the upper nasal cavity. Its ectopic origin is extremely rare, especially when located in the optical pathways. This paper reports the case of a giant ectopic esthesioneuroblastoma of the optic pathways that were surgically treated through a cranio-orbital-zygomatic (COZ) craniotomy with extensive resection, in addition to a literature review. The patient is a 46-year-old female presenting with a 4-month history of visual loss in the left eye. Since she was previously blind in the right eye from a traumatic injury, it was evolving to loss of bilateral vision. Imaging depicted an expansive infiltrating lesion involving the entire path of the right optic nerve, extending to the optic chiasm, cisternal portion of the left optic nerve, bilateral optic tract, and hypothalamus. Investigation of pituitary function was unremarkable. Esthesioneuroblastoma is a rare tumor with poorly defined standard clinical management. Its ectopic presentation makes the diagnosis even more challenging, making it difficult to manage these cases properly. Surgeons should be aware of this rare possibility, as early aggressive treatment is likely to be associated with better results.
Profiling and Functional Analysis of mRNAs during Skeletal Muscle Differentiation in Goats
Authors: Zhan Siyuan , Zhai Hongfan , Tang Min , Xue Yanan , Li Dandan , Wang Linjie , Zhong Tao , Dai Dinghui , Cao Jiaxue , Guo Jiazhong , Li Li , Zhang Hongping
Published: April 2022

Skeletal myogenesis is a complicated biological event that involves a succession of tightly controlled gene expressions. In order to identify novel regulators of this process, we performed mRNA-Seq studies of goat skeletal muscle satellite cells (MuSCs) cultured under proliferation (GM) and differentiation (DM1/DM5) conditions. A total of 19,871 goat genes were expressed during these stages, 198 of which represented novel transcripts. Notably, in pairwise comparisons at the different stages, 2551 differentially expressed genes (DEGs) were identified (p < 0.05), including 1560 in GM vs. DM1, 1597 in GM vs. DM5, and 959 in DM1 vs. DM5 DEGs. The time-series expression profile analysis clustered the DEGs into eight gene groups, three of which had significantly upregulated and downregulated patterns (p < 0.05). Functional enrichment analysis showed that DEGs were enriched for essential biological processes such as muscle structure development, muscle contraction, muscle cell development, striated muscle cell differentiation, and myofibril assembly, and were involved in pathways such as the MAPK, Wnt and PPAR signaling pathways. Moreover, the expression of eight DEGs (MYL2, DES, MYOG, FAP, PLK2, ADAM, WWC1, and PRDX1) was validated. These findings offer novel insights into the transcriptional regulation of skeletal myogenesis in goats.
Design of Third-Order Dispersion Compensation for the SG PW Laser System Using a Birefringent Crystal
Authors: Li Dawei , Wang Tao , Yin Xiaolei , Li Jiamei , Yu Hui , Wang Li , Lu Xingqiang , Xu Guang
Published: April 2022

This study aims to update the existing SG PW laser system and improve the temporal contrast and shape fidelity of a compressed pulse with a 150 fs level for multi-PW (5–10 PW). The design of third-order dispersion (TOD) compensation via a birefringent crystal was studied through numerical simulations and experiments. The dispersions introduced by the birefringent crystal were calculated using the Jones matrix element by changing the in-plane rotation angle ϕ, thickness d, incident angle θ, and temperature T, while also considering the transmission spectral bandwidth. The group-velocity dispersion (GVD), TOD, and fourth-order dispersion (FOD) of the existing SG PW laser system and its influence on the compressed pulse with different pulse durations were analyzed. The results suggest that a TOD of 1.3×106 fs3 needs to compensate for the multi-PW design. The compensation scheme is designed using a quartz crystal of d = 6.5 mm, θ = 90°, ϕ = 17°, and T = 21 °C, corresponding to the thickness, inclination angle, in-plane rotation angle, and temperature, respectively. Furthermore, we show a principle-proof experiment offline and measure the GVD and TOD by the Wizzler, which is based on theoretical simulations. These results can be applied to independently and continuously control the TOD of short-pulse laser systems.
Genome-Wide Association Study Reveals That PvGUX1_1 Is Associated with Pod Stringlessness in Snap Bean (Phaseolus vulgaris L.)
Authors: Liu Zhiyuan , Gao Shuo , Zhang Helong , Xu Zhaosheng , Qian Wei
Published: April 2022

Suture strings are a particularly important pod trait that determine the quality and texture of snap beans (Phaseolus vulgaris L.). The St locus on chromosome 2 has been described as a major locus associated with suture strings. However, the gene and genetic basis underlying this locus remain unknown. Here, we investigated the suture strings of 138 snap bean accessions across two years. A total of 3.66 million single-nucleotide polymorphisms (SNPs) were obtained by deep resequencing. Based on these SNPs, we identified a strong association signal on Chr02 and a promising candidate gene, PvGUX1_1. Further analysis revealed that the 2 bp deletion in the exon of PvGUX1_1 was significantly associated with stringlessness. Comparative mapping indicated that PvGUX1_1 was a domesticated locus and diverged from PvGUX1_2 during an early stage. Our study provides important insights into the genetic mechanism of suture string formation and useful information for snap bean improvement.
Effect of Clinical Parameters on Risk of Death from Cancer after Radical Prostatectomy in Men with Localized and Locally Advanced Prostate Cancer
Authors: Milonas Daimantas , Ruzgas Tomas , Venclovas Zilvinas , Jonusaite Daniele , Matijosaitis Aivaras Jonas , Trumbeckas Darius , Varpiotas Edmundas , Auskalnis Stasys , Skaudickas Darijus , Mickevicius Ramunas , Vaiciunas Kestutis , Mickevicius Jonas , Jievaltas Mindaugas
Published: April 2022

Background: The study aimed to assess predictors and to identify patients at increased risk of prostate-cancer-specific mortality (CSM) after radical prostatectomy (RP). Methods: A total of 2421 men with localized and locally advanced PCa who underwent RP in 2001–2017 were included in the study. CSM predictors were assessed using multivariate competing risk analysis. Death from other causes was considered a competing event. Cumulative CSM and other-cause mortality (OCM) were calculated in various combinations of predictors. Results: During the median 8 years (interquartile range 4.4–11.7) follow-up, 56 (2.3%) of registered deaths were due to PCa. Cumulative 10 years CSM and OCM was 3.6% (95% CI 2.7–4.7) and 15.9% (95% CI 14.2–17.9), respectively. The strongest predictors of CSM were Grade Group 5 (GG5) (hazard ratio (HR) 19.9, p < 0.0001), lymph node invasion (HR 3.4, p = 0.001), stage pT3b-4 (HR 3.1, p = 0.009), and age (HR 1.1, p = 0.0007). In groups created regarding age, stage, and GG, cumulative 10 years CSM ranged from 0.4–84.9%, whereas OCM varied from 0–43.2%. Conclusions: CSM after RP is related to GGs, pathological stage, age, and combinations of these factors, whereas other-cause mortality is only associated with age. Created CSM and OCM plots can help clinicians identify patients with the most aggressive PCa who could benefit from more intensive or novel multimodal treatment strategies.
Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells
Authors: Chen Lei , Yan Yang , Kong Fangen , Wang Jikai , Zeng Jia , Fang Zhen , Wang Zheyan , Liu Zhigang , Liu Fei
Published: April 2022

Background: To better understand the Ca2+ overload mechanism of SDT killing gliomas, we examined the hypothesis that the early application of the mechanosensitive Ca2+ channel Piezo1 antagonist (GsMTx4) could have a better anti-tumor effect. Methods: The in vitro effect of low-energy SDT combined with GsMTx4 or agonist Yoda 1 on both the ROS-induced distribution of Ca2+ as well as on the opening of Piezo1 and the dissociation and polymerization of the Ca2+ lipid complex were assessed. The same groups were also studied to determine their effects on both tumor-bearing BALB/c-nude and C57BL/6 intracranial tumors, and their effects on the tumor-infiltrating macrophages were studied as well. Results: It was determined that ultrasound-activated Piezo1 contributes to the course of intracellular Ca2+ overload, which mediates macrophages (M1 and M2) infiltrating under the oxidative stress caused by SDT. Moreover, we explored the effects of SDT based on the dissociation of the Ca2+ lipid complex by inhibiting the expression of fatty acid binding protein 4 (FABP4). The Piezo1 channel was blocked early and combined with SDT treatment, recruited macrophages in the orthotopic transplantation glioma model. Conclusions: SDT regulates intracellular Ca2+ signals by upregulating Piezo1 leading to the inhibition of the energy supply from lipid and recruitment of macrophages. Therefore, intervening with the function of the Ca2+ channel on the glioma cell membrane in advance is likely to be the key factor to obtain a better effect combined with SDT treatment.
Multi-Omics Approach Points to the Importance of Oxylipins Metabolism in Early-Stage Breast Cancer
Authors: Chistyakov Dmitry V. , Guryleva Mariia V. , Stepanova Elena S. , Makarenkova Lyubov M. , Ptitsyna Elena V. , Goriainov Sergei V. , Nikolskaya Arina I. , Astakhova Alina A. , Klimenko Anna S. , Bezborodova Olga A. , Rasskazova Elena A. , Potanina Olga G. , Abramovich Rimma A. , Nemtsova Elena R. , Sergeeva Marina G.
Published: April 2022

The involvement of oxylipins, metabolites of polyunsaturated fatty acids, in cancer pathogenesis was known long ago, but only the development of the high-throughput methods get the opportunity to study oxylipins on a system level. The study aimed to elucidate alterations in oxylipin metabolism as characteristics of breast cancer patients. We compared the ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) oxylipin profile signatures in the blood plasma of 152 healthy volunteers (HC) and 169 patients with different stages of breast cancer (BC). To integrate lipidomics, transcriptomics, and genomics data, we analyzed a transcriptome of 10 open database datasets obtained from tissues and blood cells of BC patients and SNP data for 33 genes related to oxylipin metabolism. We identified 18 oxylipins, metabolites of omega-3 or omega-6 polyunsaturated fatty acids, that were differentially expressed between BCvsHC patients, including anandamide, prostaglandins and hydroxydocosahexaenoic acids. DEGs analysis of tissue and blood samples from BC patients revealed that 19 genes for oxylipin biosynthesis change their expression level, with CYP2C19, PTGS2, HPGD, and FAAH included in the list of DEGs in the analysis of transcriptomes and the list of SNPs associated with BC. Results allow us to suppose that oxylipin signatures reflect the organism’s level of response to the disease. Our data regarding changes in oxylipins at the system level show that oxylipin profiles can be used to evaluate the early stages of breast cancer.
How Did Conventional Nanoparticle-Mediated Photothermal Therapy Become “Hot” in Combination with Cancer Immunotherapy?
Authors: Yun Wan Su , Park Ji-Ho , Lim Dong-Kwon , Ahn Cheol-Hee , Sun In-Cheol , Kim Kwangmeyung
Published: April 2022

One of the promising cancer treatment methods is photothermal therapy (PTT), which has achieved good therapeutic efficiency through nanoparticle-based photoabsorbers. Because of the various functions of nanoparticles, such as targeting properties, high light-to-heat conversion, and photostability, nanoparticle-mediated PTT successfully induces photothermal damage in tumor tissues with minimal side effects on surrounding healthy tissues. The therapeutic efficacy of PTT originates from cell membrane disruption, protein denaturation, and DNA damage by light-induced heat, but these biological impacts only influence localized tumor areas. This conventional nanoparticle-mediated PTT still attracts attention as a novel cancer immunotherapy, because PTT causes immune responses against cancer. PTT-induced immunogenic cell death activates immune cells for systemic anti-cancer effect. Additionally, the excellent compatibility of PTT with other treatment methods (e.g., chemotherapy and immune checkpoint blockade therapy) reinforces the therapeutic efficacy of PTT as combined immunotherapy. In this review, we investigate various PTT agents of nanoparticles and compare their applications to reveal how nanoparticle-mediated PTT undergoes a transition from thermotherapy to immunotherapy.
Novel Intraoperative Navigation Using Ultra-High-Resolution CT in Robot-Assisted Partial Nephrectomy
Authors: Takahara Kiyoshi , Ohno Yoshiharu , Fukaya Kosuke , Matsukiyo Ryo , Nukaya Takuhisa , Takenaka Masashi , Zennami Kenji , Ichino Manabu , Fukami Naohiko , Sasaki Hitomi , Kusaka Mamoru , Toyama Hiroshi , Sumitomo Makoto , Shiroki Ryoichi
Published: April 2022

To assess the perioperative and short-term functional outcomes of robot-assisted partial nephrectomy (RAPN) with intraoperative navigation using an ultra-high-resolution computed tomography (UHR-CT) scanner, we retrospectively analyzed 323 patients who underwent RAPN using an UHR-CT or area-detector CT (ADCT). Perioperative outcomes and the postoperative preservation ratio of estimated glomerular filtration rate (eGFR) were compared. After the propensity score matching, we evaluated 99 patients in each group. Although the median warm ischemia time (WIT) was less than 25 min in both groups, it was significantly shorter in the UHR-CT group than in the ADCT group (15 min vs. 17 min, p = 0.032). Moreover, the estimated blood loss (EBL) was significantly lower in the UHR-CT group than in the ADCT group (33 mL vs. 50 mL, p = 0.028). However, there were no significant intergroup differences in the postoperative preservation ratio of eGFR at 3 or 6 months of follow-up (ADCT 91.8% vs. UHR-CT 93.5%, p = 0.195; and ADCT 91.7% vs. UHR-CT 94.0%, p = 0.160, respectively). Although no differences in short-term renal function were observed in intraoperative navigation for RAPN in this propensity score–matched cohort, this study is the first to demonstrate that UHR-CT resulted in a shorter WIT and lower EBL than ADCT.
Evolutionary Ecology of Fixed Alternative Male Mating Strategies in the Ruff (Calidris pugnax)
Authors: Baguette Michel , Bataille Baptiste , Stevens Virginie M.
Published: April 2022

A few empirical examples document fixed alternative male mating strategies in animals. Here we focus on the polymorphism of male mating strategies in the ruff (Calidris pugnax, Aves Charadriiformes). In ruffs, three fixed alternative male mating strategies coexist and are signaled by extreme plumage polymorphism. We first present relevant data on the biology of the species. Then we review the available knowledge of the behavioral ecology of ruffs during the breeding season, and we detail the characteristics of each of the three known fixed male mating strategies. We next turn to the results of exceptional quality accumulated on both the structural and functional genomics of the ruff over the past few years. We show how much these genomic data can shed new, mechanistic light on the evolution and maintenance of the three fixed alternative male mating strategies. We then look if there is sufficient indication to support frequency-dependent selection as a key mechanism in maintaining these three strategies. Specifically, we search for evidence of equal fitness among individuals using each of the three strategies. Finally, we propose three lines of research avenues that will help to understand the eco-evolutionary dynamics of phenotypic differences within natural populations of this iconic model species.
Damage Modes Recognition of Wood Based on Acoustic Emission Technique and Hilbert–Huang Transform Analysis
Authors: Tu Juncheng , Yu Lichuan , Zhao Jian , Zhang Jianzhong , Zhao Dong
Published: April 2022

Identifying the different damage modes of wood is of great significance for monitoring the occurrence, development, and evolution of wood material damage. This paper presents the research results of the application of acoustic emission (AE) technology to analyze and evaluate the mapping relationship between the damage pattern of wood in the fracture process and the AE signal. For the three-point bending specimen with pre-crack, the double cantilever beam specimen, the single fiber tensile specimen, and the uniaxial compression specimen, the bending tensile compression test and the AE monitoring were performed, respectively. After the post-processing and analysis of the recorded AE signal, the results show that the peak frequency of AE is an effective parameter for identifying different damage modes of wood. In this study, the empirical mode decomposition (EMD) of the AE signal can separate and extract a variety of damage modes contained in the AE signal. The Hilbert–Huang transform (HHT) of the AE signal can clearly describe the frequency distribution of intrinsic mode function (IMF) components in different damage stages on the time scale, and can calculate instantaneous energy accurately, which provides a basis for damage mode recognition and lays a foundation for further accurate evaluation of the wood damage process.
Extending King’s Method for Finding Solutions of Equations
Authors: Regmi Samundra , Argyros Ioannis K. , George Santhosh , Argyros Christopher I.
Published: April 2022

King’s method applies to solve scalar equations. The local analysis is established under conditions including the fifth derivative. However, the only derivative in this method is the first. Earlier studies apply to equations containing at least five times differentiable functions. Consequently, these articles provide no information that can be used to solve equations involving functions that are less than five times differentiable, although King’s method may converge. That is why the new analysis uses only the operators and their first derivatives which appear in King’s method. The article contains the semi-local analysis for complex plane-valued functions not presented before. Numerical applications complement the theory.
Trends and Determinants of Cigarette Tax Increases in Japan: The Role of Revenue Targeting
Authors: Oshio Takashi , Nakamura Ryota
Published: April 2022

Cigarette prices in Japan are lower than those in most other high-income countries. A more striking fact is that cigarette tax revenues have been kept almost flat at just over two trillion JPY (Japanese yen; 18.2 billion US dollars) over more than three decades, despite steadily declining cigarette sales and seemingly weakening pressure from stakeholders with a vested interest in the tobacco industry. We attempted to examine trends and determinants of cigarette tax increases in Japan. In particular, we hypothesized that the Japanese finance ministry adjusts cigarette taxes to meet a revenue target. Under this hypothesis, we searched for the most plausible amount of the minimum target of tax revenue that corresponds to cigarette tax increases over the past 37 years (1985–2021) using public data on cigarette sales and taxes. The results revealed that two trillion JPY was the minimal revenue target that could plausibly explain the increase in cigarette tax. In addition, the timing and magnitude of cigarette tax increases have been successfully set to maintain stable tax revenues. A key determinant of cigarette tax increases in Japan has been hard revenue targets, rather than public health concerns.
Effects of Different Low-Intensity Exercise Types on Duration, Energy Expenditure and Perceived Exertion in Obese Individuals
Authors: Khanfir Mohamed Ali , Awicha Hassen Ben , Masmoudi Liwa , Hmadou Faten Ben , Dardouri Wajdi , Alardan Sultan , Nouira Sabeur , Zouch Mohamed
Published: April 2022

Physical exercise is a common strategy in overweight and obesity management. Exercise type, intensity, duration, energy expenditure and the rate of perceived exertion (RPE) are the essential determinants of exercise efficiency. The purpose of the present study was to compare continuous and intermittent exercises targeted at the maximal fat oxidation intensity (FAT max) in obese individuals. Ten obese males (BMI > 30 kg/m2; age: 19 to 35 years) who maintained a sedentary lifestyle were recruited for this study to perform three separate exhaustive exercises: a continuous exercise at FAT max (CON), an intermittent exercise that alternates two minutes at FAT max −10% with one minute at FAT max +20% (INT½), and a second intermittent exercise that alternates four minutes at FAT max −10% with one minute at FAT max +40% (INT¼). The duration of the INT¼ exercise (65.1 min ± 13.4) was significantly longer than that of the CON exercise (55.4 min ± 6.0). No significant difference in the total amount of energy expenditure was observed across the three types of exercise (CON: 372 Kcal ± 98.2, INT¼: 398 Kcal ± 145.5, INT½: 374.4 Kcal ± 116.1). The fat oxidation rate after 45 min during the INT exercises (INT¼: 93.0 ± 19.1 mg/min, INT½: 71.1 ± 15.6 mg/min) was significantly higher than that of the CON exercise (36.1 ± 12.2 mg/min). The CON exercise was less well tolerated. The rate of perceived exertion (RPE) at the end of the CON (15.8 ± 2) was significantly higher than that of the INT exercises (13.5 ± 2 for the INT¼ and 13.1 ± 1.8 for the INT½). The INT exercises were more efficient in terms of duration, fat oxidation and RPE.
The Prevalence of Tobacco, Heated Tobacco, and E-Cigarette Use in Poland: A 2022 Web-Based Cross-Sectional Survey
Authors: Jankowski Mateusz , Ostrowska Aurelia , Sierpiński Radosław , Skowron Adam , Sytnik-Czetwertyński Janusz , Giermaziak Wojciech , Gujski Mariusz , Wierzba Waldemar , Pinkas Jarosław
Published: April 2022

Monitoring tobacco use on a regular schedule is a basic tool of tobacco control policy. This study aimed (1) to assess the current prevalence and patterns of tobacco and e-cigarette use, as well as (2) to identify socioeconomic factors associated with smoking behavior among adults in Poland. This cross-sectional study was carried out in March 2022 on a nationwide, representative sample of 1090 adults in Poland. The computer-assisted web interview (CAWI) technique was used. Daily tobacco smoking was declared by 28.8% of respondents (27.1% of females and 30.8% of males; p = 0.2) and 4.2% were occasional smokers (4.2% of females and 4.3% of males; p = 0.8). Most of the current smokers (62.1%) smoked regular cigarettes and 25.2% smoked hand-rolled cigarettes. The prevalence of daily e-cigarette use was 4.8% (4.0% among females and 5.6% among males; p = 0.2). Daily heated tobacco use was declared by 4.0% of respondents (5.1% of females and 2.9% of males; p = 0.07). Age, having children, and educational level were significantly associated with current daily tobacco smoking. This study revealed a high prevalence of tobacco and e-cigarette use among adults in Poland. The presented data underscore the importance of further improvements in adopting a comprehensive tobacco control strategy in Poland.
Materialism, Egocentrism and Delinquent Behavior in Chinese Adolescents in Mainland China: A Short-Term Longitudinal Study
Authors: Shek Daniel T. L. , Dou Diya , Zhu Xiaoqin , Li Xiang , Tan Lindan
Published: April 2022

Although research generally showed that holding materialistic beliefs would lead to poor developmental outcomes, few studies have used adolescent delinquency as an outcome measure. In addition, the intervening processes between materialism and adolescent developmental outcomes are unclear. In particular, it is not clear how materialistic beliefs influence egocentrism and adolescent delinquency. Methodologically, the existing studies have several weaknesses, including small samples, cross-sectional research designs, and being limited to people living in Western cultures. Using two waves of data collected from Sichuan, China (N = 4981), we studied the predictive effect of adolescent materialism on delinquency and the mediating role of egocentrism. Over two occasions separated by six months, students aged 11 and above responded to a questionnaire evaluating adolescent materialism, egocentrism, and delinquency (mean Wave 1 age = 13.15, range between 11 and 20.38). Results of multiple regression analyses suggested that materialism at Time 1 positively predicted Time 2 egocentrism. Additionally, Time 1 materialism positively predicted the level and change in Time 2 delinquency. Finally, based on 5000 bootstrap samples with gender, age, ethnic group, and Time 1 delinquent behavior as covariates, PROCESS analyses showed that egocentrism partially mediated the influence of Time 1 materialism delinquency and its change at Time 2. This study suggests that materialistic beliefs shape egocentrism, which further strengthens adolescent delinquent behavior. This study also replicates the findings of a pioneer study in China reported previously.
Assessment of the Ecological Protection Effectiveness of Protected Areas Using Propensity Score Matching: A Case Study in Sichuan, China
Authors: Zhang Zhifeng , Tang Yuping , Pan Hongyi , Yao Caiyi , Zhang Tianyi
Published: April 2022

Protected areas constitute a global strategic resource for enhancing the effectiveness of ecological protection, which can alleviate the impact of unsustainable human production and living activities on the ecological environment. However, the spatiotemporal evolution of ecological protection effectiveness needs to be quantitatively revealed. The net primary productivity (NPP) of plants is an important measure of the effectiveness of ecological protection efforts. The main purpose of this study is to use the relative change in the annual average NPP to evaluate the ecological protection effectiveness of protected areas. We compared the historical changes in the annual average NPP of protected areas in Sichuan Province from 2000 to 2019. We added the spatial coordinates to the impact factor system and adopted propensity score matching (PSM) in a quasi-natural experimental method to determine the experimental group and the control group. The ecological protection effectiveness of the protected areas in the study area in 2000, 2005, 2010, 2015, and 2019 was measured and classified into three types of changes in protection effectiveness, namely effective, ineffective, or fluctuating. According to the administrative level, type, and spatial distribution, we determined the number and type of changes in the protection effectiveness of different protected areas. The results show that the annual average NPP of the protected areas in Sichuan Province generally fluctuated. The annual average NPP increased in 95.47% of the total protected area and decreased in 4.53%. The overall protection effectiveness of protected areas was positive and significant and gradually improved. Effective protected areas at the national, provincial, and county levels accounted for 40.27% of the total number of protected areas, and the other 14.77% of effective protected area was managed at other administrative levels. Among the different types of protected areas, the proportion of effective protected areas was highest in wild animal protected areas, followed by forest ecology protected areas, wild plant protected areas, and wetland ecology protected areas. The results of this study can provide an important reference for the verification and improvement of the ecological protection effectiveness of various protected areas.
The Developmental Trajectory of a Decade of Research on Mental Health and Well-Being amongst Graduate Students: A Bibliometric Analysis
Authors: Okoro Chioma , Owojori Oluwatobi Mary , Umeokafor Nnedinma
Published: April 2022

The journey of graduate students through academia can be a difficult road plagued with several roadblocks due to several intersectional factors. These difficulties often impact the students’ mental health with severe consequences on their well-being and personal and academic achievements. There is a critical need for researchers to conduct studies in response to the positive mental well-being for this group of trainees, considering their peculiar role in the scholarly environment. This study aimed to explore the scientific research on the health and well-being of graduate students; typify the scientific landscape and development trajectory, cooperation networks, and fundamental research areas; and identify areas of needed research in this field. A bibliometric analysis of articles indexed in Scopus and published in the past decade (2012 to 2021) was undertaken. The results revealed that the research on graduate students’ mental health and well-being has increased over the years, significantly in the past two years, probably owing to the incidence of the COVID-19 pandemic and concerns around remote learning. The highest number of publications was from the United Kingdom (U.K.) and United States (U.S.), while the organizational affiliations were mainly from universities. The most prominent source type of publications was journal articles. The result also shows a weak collaboration across countries and organizations. The study identifies other areas of useful research, collaboration, intervention strategies, and policy review.
Multidimensional Gene Regulatory Landscape of Motor Organ Pulvinus in the Model Legume Medicago truncatula
Authors: Bai Quanzi , Yang Wenjing , Qin Guochen , Zhao Baolin , He Liangliang , Zhang Xuan , Zhao Weiyue , Zhou Dian , Liu Ye , Liu Yu , He Hua , Tadege Million , Xiong Yan , Liu Changning , Chen Jianghua
Published: April 2022

Nyctinastic leaf movement of Fabaceae is driven by the tiny motor organ pulvinus located at the base of the leaf or leaflet. Despite the increased understanding of the essential role of ELONGATED PETIOLULE1 (ELP1)/PETIOLE LIKE PULVINUS (PLP) orthologs in determining pulvinus identity in legumes, key regulatory components and molecular mechanisms underlying this movement remain largely unclear. Here, we used WT pulvinus and the equivalent tissue in the elp1 mutant to carry out transcriptome and proteome experiments. The omics data indicated that there are multiple cell biological processes altered at the gene expression and protein abundance level during the pulvinus development. In addition, comparative analysis of different leaf tissues provided clues to illuminate the possible common primordium between pulvinus and petiole, as well as the function of ELP1. Furthermore, the auxin pathway, cell wall composition and chloroplast distribution were altered in elp1 mutants, verifying their important roles in pulvinus development. This study provides a comprehensive insight into the motor organ of the model legume Medicago truncatula and further supplies a rich dataset to facilitate the identification of novel players involved in nyctinastic movement.
Bio-Synthesized Nanoparticles in Developing Plant Abiotic Stress Resilience: A New Boon for Sustainable Approach
Authors: Kumari Sarika , Khanna Risheek Rahul , Nazir Faroza , Albaqami Mohammed , Chhillar Himanshu , Wahid Iram , Khan M. Iqbal R.
Published: April 2022

Agriculture crop development and production may be hampered in the modern era because of the increasing prevalence of ecological problems around the world. In the last few centuries, plant and agrarian scientific experts have shown significant progress in promoting efficient and eco-friendly approaches for the green synthesis of nanoparticles (NPs), which are noteworthy due to their unique physio-biochemical features as well as their possible role and applications. They are thought to be powerful sensing molecules that regulate a wide range of significant physiological and biochemical processes in plants, from germination to senescence, as well as unique strategies for coping with changing environmental circumstances. This review highlights current knowledge on the plant extract-mediated synthesis of NPs, as well as their significance in reprogramming plant traits and ameliorating abiotic stresses. Nano particles-mediated modulation of phytohormone content in response to abiotic stress is also displayed. Additionally, the applications and limitations of green synthesized NPs in various scientific regimes have also been highlighted.
Psoriasis and Systemic Inflammatory Disorders
Authors: Tashiro Tomoko , Sawada Yu
Published: April 2022

Psoriasis is a representative inflammatory skin disease occupied by large surface involvement. As inflammatory cells and cytokines can systemically circulate in various organs, it has been speculated that psoriatic skin inflammation influences the systemic dysfunction of various organs. Recent updates of clinical studies and experimental studies showed the important interaction of psoriasis to systemic inflammatory diseases. Furthermore, the importance of systemic therapy in severe psoriasis is also highlighted to prevent the development of systemic inflammatory diseases. In this review, we introduced representative systemic inflammatory diseases associated with psoriasis and the detailed molecular mechanisms.