bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantum optical induced-coherence tomography by a hybrid interferometer
Authors: Kim Eun Mi , Lee Sun Kyung , Lee Sang Min , Kang Myeong Soo , Park Hee Su
Published: December 2023

Quantum interferometry based on induced-coherence phenomena has demonstrated the possibility of undetected-photon measurements. Perturbation in the optical path of probe photons can be detected by interference signals generated by quantum mechanically correlated twin photons propagating through a different path, possibly at a different wavelength. To the best of our knowledge, this work demonstrates for the first time a hybrid-type induced-coherence interferometer that incorporates a Mach–Zehnder-type interferometer for near-visible photons and a Michelson-type interferometer for infrared (IR) photons, based on double-pass-pumped spontaneous parametric down-conversion. This configuration enables IR optical measurements via the detection of near-visible photons and provides methods for optimizing the quality of measurements by identifying photon pairs of different origins. We theoretically identify that the induced-coherence interference visibility is approximately the same as the heralding efficiency between twin photons along the relevant spatial modes, and experimentally maximize the visibility by setting up a common reference spatial mode for IR photons. Applications to both time-domain and frequency-domain quantum optical induced-coherence tomography for three-dimensional test structures are demonstrated. The results prove the feasibility of practical undetected-photon sensing and imaging techniques based on the presented structure.
Position control performance analysis of linear actuator in swashplate-controlled electro hydrostatic actuation system
Authors: Kumar Gulshan , Mandal Nimai Pada
Published: December 2023

The position control of an energy efficient electrohydraulic actuation system is a decisive characteristic of its performance. In position control applications, a servo valve and/or variable displacement pump are vital to control the position of the linear actuator. In this open-loop control experimental work, the position of a linear actuator having a stroke length of 0.2 m is controlled by a swashplate-controlled electro hydrostatic actuation system. LabVIEW is used to create the control algorithm, and the National Instrument compact-RIO controller is used to control the voltage supply. The National Instruments controller processes sinusoidal and square demand signals at frequencies of 1/16, 1/12, 1/8, and 1/4 Hz. Open-loop control performance is predominantly dependent on the appropriate tuning of the voltage supply. Control performance is evaluated using the parameters integrated absolute error, integrated square error, integrated time absolute error, and integrated time square error. In comparison to square demand, it has been found that sinusoidal demand offers better position control accuracy, and square demand also offers appropriate control accuracy only at lower frequencies (1/16 Hz).
Breaking the Bonds of Segregation
Authors: Jenkins Destin
Published: December 2023

This article uncovers the financial knowledge and bond market campaigns of the paradigmatic non-violent revolution of the twentieth century—the civil rights movement. It builds on an interpretation made by the Congress of Racial Equality (CORE) and the National Association for the Advancement of Colored People (NAACP) during the early 1960s: segregation was a national problem because it was financed through a network of bankers across the country who specialized in the business of debt; certified by prominent bond attorneys in New York City, Chicago, and elsewhere; and because investors from around the country collected tax-exempt interest payments from indebted southern segregated municipalities.

By weaving the internal memos, protest ephemera, and legal strategies of civil rights activists together with the credit assessments, scheduled bond offerings, and perspectives of financiers, this article reconstructs the attempts to politicize bond market transactions and efforts to place the economic certainty of segregation in doubt. In so doing, it offers a fresh perspective on the so-called classic phase of the civil rights movement (1954–1965). More generally, it raises powerful questions about the dilemmas of investment-focused campaigns, and how finance capital compounds the difficulties of organizing against authoritarian regimes.
Grandmaternal body mass index in early pregnancy and risk of grandoffspring stillbirth: a nationwide, 3-generation cohort study
Authors: Villamor Eduardo , Cnattingius Sven
Published: December 2023

We investigated the association between maternal grandmaternal early pregnancy body mass index (BMI) and grandoffspring stillbirth risk in a Swedish population-based 3-generation cohort of 176 908 grandmothers (F0), 197 579 mothers (F1), and 316 459 grandoffspring (F2) born 1997-2016. There were 998 stillbirths (risk, 3.2 per 1000 births). Compared with grandmaternal BMI 18.5-24.9, adjusted relative risks (RRs) of grandoffspring stillbirth for BMIs of 25.0-29.9 and ≥30.0 were, respectively, 1.41 (95% CI, 1.15-1.72) and 1.62 (95% CI, 1.14-2.30). RRs for corresponding maternal (F1) BMI categories were, respectively, 1.32 (95% CI, 1.06-1.65) and 1.77 (95% CI, 1.39-2.25). Maternal BMI mediated only 19% of this relationship. Grandmaternal preeclampsia and maternal small-for-gestational age (SGA) birth were related to increased F2 stillbirth risk but did not mediate the association between grandmaternal BMI and grandoffspring stillbirth risk. To explore whether this association was explained by factors shared within families, we studied the relationship of maternal full sisters’ BMI and stillbirth risk in 101 368 pregnancies. Stillbirth RRs for full sisters’ BMI 25.0-29.9 and ≥30.0 compared with 18.5-24.9 were, respectively, 0.76 (95% CI, 0.51-1.13) and 0.88 (95% CI, 0.55-1.40). In conclusion, grandmaternal overweight and obesity were associated with grandoffspring stillbirth. This association is not fully explained by shared familial factors.
Integrating multi-omics data to analyze the potential pathogenic mechanism of CTSH gene involved in type 1 diabetes in the exocrine pancreas
Authors: Song Zerun , Li Shuai , Shang Zhenwei , Lv Wenhua , Cheng Xiangshu , Meng Xin , Chen Rui , Zhang Shuhao , Zhang Ruijie
Published: December 2023

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing pancreatic islet beta cells. Despite significant advancements, the precise pathogenesis of the disease remains unknown. This work integrated data from expression quantitative trait locus (eQTL) studies with Genome wide association study (GWAS) summary data of T1D and single-cell transcriptome data to investigate the potential pathogenic mechanisms of the CTSH gene involved in T1D in exocrine pancreas. Using the summary data–based Mendelian randomization (SMR) approach, we obtained four potential causative genes associated with T1D: BTN3A2, PGAP3, SMARCE1 and CTSH. To further investigate these genes’roles in T1D development, we validated them using a scRNA-seq dataset from pancreatic tissues of both T1D patients and healthy controls. The analysis showed a significantly high expression of the CTSH gene in T1D acinar cells, whereas the other three genes showed no significant changes in the scRNA-seq data. Moreover, single-cell WGCNA analysis revealed the strongest positive correlation between the module containing CTSH and T1D. In addition, we found cellular ligand–receptor interactions between the acinar cells and different cell types, especially ductal cells. Finally, based on functional enrichment analysis, we hypothesized that the CTSH gene in the exocrine pancreas enhances the antiviral response, leading to the overexpression of pro-inflammatory cytokines and the development of an inflammatory microenvironment. This process promotes β cells injury and ultimately the development of T1D. Our findings offer insights into the underlying pathogenic mechanisms of T1D.
Infectious Inequity: How the Gut Microbiome and Social Determinants of Health May Contribute to Clostridioides difficile Infection Among Racial and Ethnic Minorities
Authors: Reveles Kelly R , Strey Kelsey A , Abdul-Mutakabbir Jacinda C , Mendoza V Mateo , Carreno Joseph J
Published: December 2023

Infectious diseases are a leading contributor to death in the United States, and racial differences in clinical outcomes have been increasingly reported. Clostridioides difficile infection (CDI) is a growing public health concern, as it causes nearly half a million infections per year and considerable excess hospital costs. Concurrent with other infectious diseases, recent literature denotes racial disparities in CDI incidence rates, mortality, and associated morbidity. Of note, investigations into CDI and causative factors suggest that inequities in health-related social needs and other social determinants of health (SDoH) may cause disruption to the gut microbiome, thereby contributing to the observed deleterious outcomes in racially and ethnically minoritized individuals. Despite these discoveries, there is limited literature that provides context for the recognized racial disparities in CDI, particularly the influence of structural and systemic barriers. Here, we synthesize the available literature describing racial inequities in CDI outcomes and discuss the interrelationship of SDoH on microbiome dysregulation. Finally, we provide actionable considerations for infectious diseases professionals to aid in narrowing CDI equity gaps.
Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection Prevention
Authors: Lavoie Thomas , Appaneal Haley J , LaPlante Kerry L
Published: December 2023

The profound impact of the human microbiome on health and disease has captivated the interest of clinical and scientific communities. The human body hosts a vast array of microorganisms collectively forming the human microbiome, which significantly influences various physiological processes and profoundly shapes overall well-being. Notably, the gut stands out as an exceptional reservoir, harboring the most significant concentration of microorganisms, akin to an organ in itself. The gut microbiome's composition and function are influenced by genetics, environment, age, underlying conditions, and antibiotic usage, leading to dysbiosis and pathogenesis, such as Clostridioides difficile infection (CDI). Conventional CDI treatment, involving antibiotics like oral vancomycin and fidaxomicin, fails to address dysbiosis and may further disrupt gut microbial communities. Consequently, emerging therapeutic strategies are focused on targeting dysbiosis and restoring gut microbiota to advance CDI therapeutics. Fecal microbiota transplantation (FMT) has demonstrated remarkable efficacy in treating recurrent CDI by transferring processed stool from a healthy donor to a recipient, restoring gut dysbiosis and enhancing bacterial diversity. Moreover, 2 newer Food and Drug Administration (FDA)-approved live biotherapeutic products (LBP), namely, Fecal Microbiota Live-JSLM and Fecal Microbiota Spores Live-BRPK, have shown promise in preventing CDI recurrence. This review explores the role of the gut microbiota in preventing and treating CDI, with an emphasis on gut-based interventions like FMT and fecal microbiota-based products that hold potential for gut restoration and prevention of CDI recurrence. Understanding the microbiome's impact on CDI prevention and treatment offers valuable insights for advancing future CDI therapeutics.
Effectiveness and Implementation of an EnhanceFitness Physical Activity Intervention Specifically in Adults With Arthritis: A RE-AIM Evaluation
Authors: Jones Dina L , Eicher Jennifer L , Fang Wei , Hootman Jennifer M
Published: December 2023

Background and Objectives

This study evaluated the effectiveness of the evidence-based, EnhanceFitness (EF) physical activity (PA) intervention in improving arthritis symptoms, physical and mental function, and PA in adults with arthritis.

Research Design and Methods

This was a community-based, randomized, controlled effectiveness trial that switched to a nonrandomized controlled trial. Participants were sedentary/low-active adults, aged ≥18 years, with self-reported physician-diagnosed arthritis, who were assigned to an immediate or delayed group (12-week, wait-list control group). Classes were held thrice weekly for 12 weeks at 17 community sites in 4 urban and 5 rural West Virginia counties. Data were collected at baseline, 12 weeks, and 24 weeks. The RE-AIM Framework evaluated EF’s: (1) reach (enrollment); (2) effectiveness (outcomes); (3) adoption (proportion of sites/instructors that delivered EF); (4) implementation (attendance, fidelity, adverse events, and satisfaction); and (5) maintenance (EF continuation). Outcomes were analyzed using linear mixed-effects regression.

Results

There were 323 adults with a mean age of 68.3 years (range 27–95). Reach was 74%; site and instructor adoption rates were 100% and 55%, respectively; attendance (1.8 sessions per week) and fidelity were good; injury rate was low (3.8%); participants were highly satisfied and experienced improvements in arthritis symptoms and physical function; and 27% of instructors and 18% of sites continued EF.

Discussion and Implications

EnhanceFitness was safe and effective in improving arthritis symptoms and physical function in sedentary/low-active adults with arthritis, across the adult age spectrum, under real-world conditions, in both urban and rural communities.

Clinical Trial Registration: NCT00526201
Insights on the 2023 Kahramanmaraş Earthquake, Turkey, from InSAR: fault locations, rupture styles and induced deformation
Authors: Kobayashi Tomokazu , Munekane Hiroshi , Kuwahara Masaki , Furui Haruna
Published: December 2023

We successfully detected widely distributed ground displacements for the 2023 Kahramanmaraş, Turkey, earthquakes by conducting interferometric synthetic aperture radar (InSAR) analyses using a ScanSAR observation mode. Major deformation extended approximately 350 and 150 km along the southern and northern strands bifurcating in the west of the East Anatolian Fault, produced by the main shock and the largest aftershock. The deformation map reveals that the ruptures propagated on the Erkenek, Pazarcık and Amanos segments on the southern strand and the Çardak segment on the northern strand. The fault plane of the northern strand bends approximately 45° at both edges with Z-shaped crank geometry. The bending fault at the western edge runs just along the Çardak segment but does not reach the Savrun segment, while at the eastern edge it deviates from known active faults such as Sürgü, Malatya faults and Doğansehır fault zone. A 3-D displacement map demonstrates that almost pure left-lateral fault motions were distributed along the two strands, with little vertical deformation. The moment magnitudes estimated from the slip distribution model were 7.82 and 7.66 for the southern and northern strands, respectively, with the Erkenek and Çardak segments having the largest released seismic moments on each strand, corresponding to approximately 31 and 57 per cent of the total, respectively. The Coulomb Failure Function change values indicate that the main shock can promote the largest aftershock with a standard value of the effective friction coefficient. Additionally, the unclamping effect controlled by the frictional property of the rock was a key factor in pulling the trigger of the seismic event on the northern strand. The historically accumulated and released seismic energies were imbalanced for the Pazarcık and Erkenek segments, suggesting that the 2023 event does not support a simple characteristic earthquake model; rather, it may be consistent with a supercycle model, in which the slip remnants from the characteristic earthquakes have been historically accumulated as coupling on a fault and released as huge earthquakes at longer intervals.
Second screening and trust in professional and alternative media: the mediating role of media efficacy
Authors: Cheng Zicheng , Yang Yin , Gil de Zúñiga Homero
Published: December 2023

In the media convergence landscape, consumption of traditional, well-established media is increasingly combined with newer digital and online platforms such as blogs, podcasts, and social media, which has changed the way news users engage with media content. This study examines the relationship between hybrid media use—specifically, second screening—and trust in both professional and alternative media. Drawing on a two-wave U.S. panel data, first, we find that the second screening positively predicts individuals’ belief in the media’s ability to help them comprehend complex political matters, known in the literature as media efficacy. Furthermore, second screening is positively associated with alternative media trust but is not significantly related to trust in professional media. However, media efficacy positively mediates the connection between second screening and trust in both alternative and professional media. By delivering valuable information to help the public understand intricate political topics, the second screening promotes news media trust.
Utility of a Pediatric Psychosocial Screener in an Outpatient Burn Clinic
Authors: Williford Desireé N , Jackson Carrie B , Durkin Kristine , Langholz Ariana , Aballay Ariel , Duncan Christina L
Published: December 2023

Psychosocial concerns are common among youth who sustained a burn injury. Detecting psychosocial distress early is essential to ensure appropriate treatment and referrals. Thus far, research has focused largely on the long-term outcomes of pediatric burn survivors. The current quality improvement initiative details the implementation and outcomes of brief, pragmatic screening to assess psychosocial concerns among pediatric burn survivors in an outpatient setting. A primary caregiver completed an age-appropriate psychosocial screener for youth aged 4-10 years (n = 69), while patients aged 11-17 years (n = 72) completed a self-report screener. Total scores were used to categorize patients as acute risk (i.e., emotional concerns requiring immediate attention), moderate risk (i.e., elevated symptoms, but no immediate safety concerns), or low risk (i.e., endorsing few to no symptoms). Patients with acute risk were evaluated by medical staff to determine the need for immediate psychiatric intervention or social services referrals. Patients with moderate risk met with the on-site psychology team during their clinic visit or were contacted by telephone within 1 week. Patients in the low-risk category warranted no additional follow-up post-screening. Most patients scored in the low-risk category (n = 120; 85%), while 11% (n = 16) and 4% (n = 5) endorsed symptoms consistent with moderate and acute risk, respectively. Results demonstrate the utility of implementing pediatric psychosocial screening in an outpatient burn clinic, the importance of detecting psychosocial concerns in this context, and usage of referrals to address concerns. Findings also shed light on key caveats of psychosocial screening, barriers to accessing psychosocial support, and the potential benefits of embedded psychological support during medical visits.
Nastiness in Groups
Authors: Bauer Michal , Cahlíková Jana , Celik Katreniak Dagmara , Chytilová Julie , Cingl Lubomír , Želinský Tomáš
Published: December 2023

This paper provides evidence showing that people are more prone to engage in nasty behavior, malevolently causing financial harm to other people at own costs, when they make decisions in a group context rather than when making choices individually on their own. We establish this behavioral regularity in a series of large-scale experiments among university students, adolescents, and nationally representative samples of adults—more than ten thousand subjects in total. We test several potential mechanisms, and the results suggest that individual nasty inclinations are systematically more likely to affect behavior when decisions are made under the “cover” of a group, that is, in a group decision-context that creates a perception of diffused responsibility.
Characterization and catalytic investigation of fungal single-module nonribosomal peptide synthetase in terpene-amino acid meroterpenoid biosynthesis
Authors: Tseng Cheng-Chung , Chen Li-Xun , Lee Chi-Fang , Tu Zhijay , Lin Chun-Hung , Lin Hsiao-Ching
Published: December 2023

Hybrid natural products are compounds that originate from diverse biosynthetic pathways and undergo a conjugation process, which enables them to expand their chemical diversity and biological functionality. Terpene-amino acid meroterpenoids have garnered increasing attention in recent years, driven by the discovery of noteworthy examples such as the anthelmintic CJ-12662, the insecticidal paeciloxazine, and aculene A (1). In the biosynthesis of terpene-amino acid natural products, single-module nonribosomal peptide synthetases (NRPSs) have been identified to be involved in the esterification step, catalyzing the fusion of modified terpene and amino acid components. Despite prior investigations into these NRPSs through gene deletion or in vivo experiments, the enzymatic basis and mechanistic insights underlying this family of single-module NRPSs remain unclear. In this study, we performed biochemical characterization of AneB by in vitro characterization, molecular docking, and site-directed mutagenesis. The enzyme reaction analyses, performed with L-proline and daucane/nordaucane sesquiterpene substrates, revealed that AneB specifically esterifies the C10-OH of aculenes with L-proline. Notably, in contrast to ThmA in CJ-12662 biosynthesis, which exclusively recognizes oxygenated amorpha-4,11-diene sesquiterpenes for L-tryptophan transfer, AneB demonstrates broad substrate selectivity, including oxygenated amorpha-4,11-diene and 2-phenylethanol, resulting in the production of diverse unnatural prolyl compounds. Furthermore, site-directed mutagenesis experiments indicated the involvement of H794 and D798 in the esterification catalyzed by AneB. Lastly, domain swapping between AneB and ThmA unveiled that the A‒T domains of ThmA can be effectively harnessed by the C domain of AneB for L-tryptophan transfer, thus highlighting the potential of the C domain of AneB for generating various terpene-amino acid meroterpenoid derivatives.

One-Sentence Summary

The enzymatic basis and mechanistic insights into AneB, a single-module NRPS, highlight its capacity to generate various terpene-amino acid meroterpenoid derivatives.
How should we decide how to treat the child: harm versus best interests in cases of disagreement
Authors: Archard David , Cave Emma , Brierley Joe
Published: December 2023

Where parents seek treatment for their young child that healthcare professionals cannot agree to, the High Court can determine what is in the child’s best interests. Some activists and academics seek change to impose threshold criteria that would bolster the decision-making rights of parents and reduce deference to clinicians and the courts. We defend the best interests standard against arguments that a higher threshold of ‘significant harm’ should apply. We do so from ethical, legal, and clinical perspectives. The matter is of significant moral and practical importance, especially in light of the divergence of academic opinion, the burgeoning number of cases coming before the courts and recent case law and statutory attempts to effect change. We begin by disputing ethical claims that a significant harm threshold is preferable to the best interests standard, and then we set out jurisprudential and practical arguments that demonstrate the imprudence of a significant harm threshold and defend the established yardstick of best interests.
The first ground-based detection of the 752 GHz water line in local ultraluminous infrared galaxies using APEX-SEPIA
Authors: Quinatoa Daysi , Yang Chentao , Ibar Edo , Humphreys Elizabeth , Aalto Susanne , Barcos-Muñoz Loreto , González-Alfonso Eduardo , Impellizzeri Violette , Jaffé Yara , Liu Lijie , Martín Sergio , Weiss Axel , Zhang Zhi-Yu
Published: December 2023

We report the first ground-based detection of the water line p-H2O (211–202) at 752.033 GHz in three z < 0.08 ultraluminous infrared galaxies (ULIRGs): IRAS 06035-7102, IRAS 17207-0014, and IRAS 09022-3615. Using the Atacama Pathfinder EXperiment (APEX), with its Swedish-ESO PI Instrument for APEX (SEPIA) band-9 receiver, we detect this H2O  line with overall signal-to-noise ratios of 8–10 in all three galaxies. Notably, this is the first detection of this line in IRAS 06035-7102. Our new APEX-measured fluxes, between 145 and 705 Jy km s−1, are compared with previous values taken from Herschel SPIRE FTS. We highlight the great capabilities of APEX for resolving the H2O  line profiles with high spectral resolutions while also improving by a factor of two the significance of the detection within moderate integration times. While exploring the correlation between the p-H2O(211–202) and the total infrared luminosity, our galaxies are found to follow the trend at the bright end of the local ULIRG’s distribution. The p-H2O(211–202) line spectra are compared to the mid-J CO and HCN spectra, and dust continuum previously observed with ALMA. In the complex interacting system IRAS 09022-3615, the profile of the water emission line is offset in velocity with respect to the ALMA CO(J = 4–3) emission. For IRAS 17207-0014 and IRAS 06035-7102, the profiles between the water line and the CO lines are spectroscopically aligned. This pilot study demonstrates the feasibility of directly conducting ground-based high-frequency observations of this key water line, opening the possibility of detailed follow-up campaigns to tackle its nature.
Neutrinos from pre-supernova in the framework of TQRPA method
Authors: Dzhioev A A , Yudin A V , Dunina-Barkovskaya N V , Vdovin A I
Published: December 2023

We propose a new method for calculating spectra and luminosities for (anti)neutrinos produced in the pre-supernova environment by weak processes with hot nuclei. It is based on the thermal quasiparticle random phase approximation (TQRPA), which allows microscopic thermodynamically consistent calculations of the weak interaction response of nuclei at finite temperatures. For realistic representative pre-supernova conditions from the stellar evolution code MESA, we compute (anti)neutrino luminosities and spectra arising from neutral- and charged-current weak reactions with hot 56Fe and compare them with the contribution of thermal processes. We find that the TQRPA approach produces not only a higher total luminosity of electron neutrinos (mainly born in the electron capture reaction), compared to the standard technique based on the large-scale shell model (LSSM) weak interaction rates, but also a harder neutrino spectrum. Besides, applying the TQRPA and LSSM, we find that in the context of electron antineutrino generation, the neutral-current nuclear de-excitation (ND) process via neutrino-antineutrino pair emission is at least as important as the electron–positron pair annihilation process. We also show that flavour oscillations enhance the high-energy contribution of the ND process to the electron antineutrino flux. This could potentially be important for pre-supernova antineutrino registration by the Earth’s detectors.
Using transition density models to interpret experimental optical spectra of exciton-coupled cyanine (iCy3)2 dimer probes of local DNA conformations at or near functional protein binding sites
Authors: Heussman Dylan , Enkhbaatar Lulu , Sorour Mohammed I , Kistler Kurt A , von Hippel Peter H , Matsika Spiridoula , Marcus Andrew H
Published: December 2023

Exciton-coupled chromophore dimers are an emerging class of optical probes for studies of site-specific biomolecular interactions. Applying accurate theoretical models for the electrostatic coupling of a molecular dimer probe is a key step for simulating its optical properties and analyzing spectroscopic data. In this work, we compare experimental absorbance and circular dichroism (CD) spectra of ‘internally-labeled’ (iCy3)2 dimer probes inserted site-specifically into DNA fork constructs to theoretical calculations of the structure and geometry of these exciton-coupled dimers. We compare transition density models of varying levels of approximation to determine conformational parameters of the (iCy3)2 dimer-labeled DNA fork constructs. By applying an atomistically detailed transition charge (TQ) model, we can distinguish between dimer conformations in which the stacking and tilt angles between planar iCy3 monomers are varied. A major strength of this approach is that the local conformations of the (iCy3)2 dimer probes that we determined can be used to infer information about the structures of the DNA framework immediately surrounding the probes at various positions within the constructs, both deep in the duplex DNA sequences and at sites at or near the DNA fork junctions where protein complexes bind to discharge their biological functions.
Infrared imaging of magnetic octupole domains in non-collinear antiferromagnets
Authors: Wang Peng , Xia Wei , Shen Jinhui , Chen Yulong , Peng Wenzhi , Zhang Jiachen , Pan Haolin , Yu Xuhao , Liu Zheng , Gao Yang , Niu Qian , Xu Zhian , Yang Hongtao , Guo Yanfeng , Hou Dazhi
Published: December 2023

Magnetic structure plays a pivotal role in the functionality of antiferromagnets (AFMs), which not only can be employed to encode digital data but also yields novel phenomena. Despite its growing significance, visualizing the antiferromagnetic domain structure remains a challenge, particularly for non-collinear AFMs. Currently, the observation of magnetic domains in non-collinear antiferromagnetic materials is feasible only in Mn3Sn, underscoring the limitations of existing techniques that necessitate distinct methods for in-plane and out-of-plane magnetic domain imaging. In this study, we present a versatile method for imaging the antiferromagnetic domain structure in a series of non-collinear antiferromagnetic materials by utilizing the anomalous Ettingshausen effect (AEE), which resolves both the magnetic octupole moments parallel and perpendicular to the sample surface. Temperature modulation due to AEE originating from different magnetic domains is measured by lock-in thermography, revealing distinct behaviors of octupole domains in different antiferromagnets. This work delivers an efficient technique for the visualization of magnetic domains in non-collinear AFMs, which enables comprehensive study of the magnetization process at the microscopic level and paves the way for potential advancements in applications.
Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation
Authors: Wu Zhanfeng , Liu Lei , Li Lei , Cao Xinran , Jia Wang , Liao Xiaodan , Zhao Zhongpu , Qi Hedong , Fan Guoqiang , Lu Huiqiang , Shu Chunying , Zhen Mingming , Wang Chunru , Bai Chunli
Published: December 2023

Sleep deprivation (SD) is a severe public health threat that can cause systemic inflammation and nerve damage. Few effective and side-effect-free drugs are available to address SD. However, the bidirectional communications between the brain and gut provide new strategies for anti-SD therapeutics. Here we explored oral delivery of fullerene nano-antioxidants (FNAO) in the SD model to improve sleep by regulating abnormal intestinal barrier and systemic inflammation via the brain-gut axis. SD caused excessive reactive oxygen species (ROS) production and hyperactive inflammatory responses in the intestines of zebrafish and mouse models, leading to disturbed sleep patterns and reduced brain nerve activity. Of note, based on the property of the conjugated π bond of the C60 structure to absorb unpaired electrons, oral FNAO efficiently reduced the excessive ROS in the intestines, maintained redox homeostasis and intestinal barrier integrity, and ameliorated intestinal and systemic inflammation, resulting in superior sleep improvement. Our findings suggest that maintaining intestinal homeostasis may be a promising avenue for SD-related nerve injury therapy.
Estimating the Burden of Clinically Significant Staphylococcus aureus Infections and Predictors for Hospitalization for Skin and Soft Tissue Infections, Fulton County, Georgia, 2017
Authors: Phillip Katherine I , Webster Andrew S , Ray Susan M , Britton Amber , Swerdlow David , Fridkin Scott K
Published: December 2023

Background

Incidence estimates of Staphylococcus aureus infections rarely include the full spectrum of clinically relevant disease from both community and healthcare settings.

Methods

We conducted a prospective study capturing all S aureus infections in Fulton County, Georgia, during 2017. Medical records of patients with any incident infection (clinical cultures growing S aureus from any site, without prior positive culture in previous 14 days) were reviewed. Estimates of disease incidence were calculated using age-, race-, and sex-specific population denominators accounting for weighted sampling methods. Multivariable logistic regression models were used to identify risk factors for hospitalization among patients with skin and soft tissue infections (SSTIs).

Results

The overall incidence of clinically relevant S aureus infection was 405.7 cases per 100 000 people (standard error [SE], 5.62 [range, 400.1–411.3]). Overall incidence for those of Black race was 500.84 cases per 100 000 people (SE, 14.55), whereas White patients had overall incidence of 363.67 cases per 100 000 people (SE, 13.8). SSTIs were the most common infection (2351; 225.8 cases per 100 000 people [SE, 7.1]), and 30% required hospitalization. Among SSTIs, after adjusting for invasive disease, cellulitis, diabetes, and demographics, independent predictors of hospitalization included methicillin-resistant S aureus (adjusted odds ratio [aOR], 1.6 [95% confidence interval {CI}, 1.0–2.7]) and homelessness (aOR, 4.9 [95% CI, 1.1–22]).

Conclusions

The burden of clinically relevant S aureus infections is high, particularly among the Black population, and risks for hospitalization among SSTIs include isolate factors and factors related to patients’ vulnerability.
PSEUDO-ETIOLATION IN LIGHT proteins reduce greening by binding GLK transcription factors
Authors: Han Yuting , Li Fengfei , Wu Ying , Wang Dong , Luo Guangbao , Wang Xinning , Wang Xin , Kuang Hanhui , Larkin Robert M
Published: December 2023

Knocking out genes encoding proteins that downregulate the accumulation of pigments may lead to increases in crop quality and yield. PSEUDO-ETIOLATION IN LIGHT 1 (PEL1) downregulates the accumulation of carotenoids in carrot and chlorophyll in Arabidopsis and rice and may inhibit GOLDEN 2-LIKE (GLK) transcription factors. PEL1 belongs to a previously unstudied gene family found only in plants. We used CRISPR/Cas9 technology to knock out each member of the 4-member PEL gene family and both GLK genes in Arabidopsis. In pel mutants, chlorophyll levels were elevated in seedlings; after flowering, chloroplasts increased in size, and anthocyanin levels increased. Although the chlorophyll-deficient phenotype of glk1 glk2 was epistatic to pel1 pel2 pel3 pel4 in most of our experiments, glk1 glk2 was not epistatic to pel1 pel2 pel3 pel4 for the accumulation of anthocyanins in most of our experiments. The pel alleles attenuated growth, altered the accumulation of nutrients in seeds, disrupted an abscisic acid-inducible inhibition of seedling growth response that promotes drought tolerance, and affected the expression of genes associated with diverse biological functions, such as stress responses, cell wall metabolism hormone responses, signaling, growth, and the accumulation of phenylpropanoids and pigments. We found that PEL proteins specifically bind 6 transcription factors that influence the accumulation of anthocyanins, GLK2, and the carboxy termini of GLK1 and Arabidopsis thaliana myeloblastosis oncogene homolog 4 (AtMYB4). Our data indicate that the PEL proteins influence the accumulation of chlorophyll and many other processes, possibly by inhibiting GLK transcription factors and via other mechanisms, and that multiple mechanisms downregulate chlorophyll content.
The silver bullet that wasn’t: Rapid agronomic weed adaptations to glyphosate in North America
Authors: Landau Christopher , Bradley Kevin , Burns Erin , Flessner Michael , Gage Karla , Hager Aaron , Ikley Joseph , Jha Prashant , Jhala Amit , Johnson Paul O , Johnson William , Lancaster Sarah , Legleiter Travis , Lingenfelter Dwight , Loux Mark , Miller Eric , Norsworthy Jason , Owen Micheal , Nolte Scott , Sarangi Debalin , Sikkema Peter , Sprague Christy , VanGessel Mark , Werle Rodrigo , Young Bryan , Williams Martin M
Published: December 2023

The rapid adoption of glyphosate-resistant crops at the end of the 20th century caused a simplification of weed management that relied heavily on glyphosate for weed control. However, the effectiveness of glyphosate has diminished. A greater understanding of trends related to glyphosate use will shed new light on weed adaptation to a product that transformed global agriculture. Objectives were to (1) quantify the change in weed control efficacy from postemergence (POST) glyphosate use on troublesome weeds in corn and soybean and (2) determine the extent to which glyphosate preceded by a preemergence (PRE) improved the efficacy and consistency of weed control compared to glyphosate alone. Herbicide evaluation trials from 24 institutions across the United States of America and Canada from 1996 to 2021 were compiled into a single database. Two subsets were created; one with glyphosate applied POST, and the other with a PRE herbicide followed by glyphosate applied POST. Within each subset, mean and variance of control ratings for seven problem weed species were regressed over time for nine US states and one Canadian province. Mean control with POST glyphosate alone decreased over time while variability in control increased. Glyphosate preceded by a labeled PRE herbicide showed little change in mean control or variability in control over time. These results illustrate the rapid adaptation of agronomically important weed species to the paradigm-shifting product glyphosate. Including more diversity in weed management systems is essential to slowing weed adaptation and prolonging the usefulness of existing and future technologies.
News from Home: How Local Media Shapes Climate Change Attitudes
Authors: Andrews Talbot M , Kim Cana , Kim Jeong Hyun
Published: December 2023

Highlighting the local impacts of climate change has the potential to increase the public’s awareness of and engagement with climate change. However, information about local impacts is only effective when delivered by trusted sources such as copartisan political leaders. Is information about climate change conveyed by local media sources similarly beneficial? We argue that local media are well positioned to communicate the local implications of climate change, thereby enhancing the public’s risk perceptions of climate change and willingness to take climate action. We further hypothesize that climate coverage by local media, the media type that is more trusted across party lines, will have a significant influence on Republicans’ climate attitudes. Using the case of Louisiana, we first demonstrate that local and national newspapers cover climate change in substantially different ways, with local media more consistently focused on local impacts. Our survey experiment of Louisiana residents reveals that Republicans viewed the coverage of a hurricane in the region more positively when it came from a local newspaper rather than a national newspaper. Furthermore, local newspapers’ climate coverage increased Republicans’ willingness to take action to mitigate climate change. These results provide insights into the effective communication of climate change to the public and the role of local media in mitigating partisan polarization.
Impurity and hybridization effects on the symmetry classification and magnetic response function of a two-band superconductor with interband pairing order
Authors: Aghamohammadi Renani F , Yavari H
Published: December 2023

The effects of hybridization and impurity (magnetic and nonmagnetic) potentials on the pairing symmetries and magnetic response of a two-band superconductor with an equal-time s-wave interband pairing order parameter in the framework of Green’s function technique are investigated theoretically. First, the effects of spin-independent and spin-dependent hybridization on the generation of even- or odd-frequency Cooper pairs which determines the symmetry classification and the response of the superconductor are studied. Next, the impurity effect on creating different symmetry classes and the kernel response function of a two-band superconductor are discussed. By separating the contributions of even- and odd-frequency pairing to the Meissner kernel, it is shown that the competition between these two terms determines the total Meissner effect of the superconductor. For a two-band spin-singlet superconductor, nonmagnetic impurity scatterings do not change transition temperature according to Anderson’s theorem, while both intra- and interband magnetic impurity scattering cause superconducting transition temperature suppression with the rate following the Abrikosov–Gor’kov theory. For spin-triplet pairing, interband magnetic scattering has no impact on pair breaking, whereas intraband magnetic scattering acts as a pair breaker and suppresses the transition temperature in the Born limit. In this case, the odd-frequency superconducting pairs can be induced in the simultaneous presence of both intra- and interband magnetic impurities. Thus, by controlling the concentration of magnetic impurities, it is possible to engineer triplet-pairing odd-frequency superconductors with a total diamagnetic Meissner response which stabilizes the superconducting state. This technique opens up an avenue for designing stable odd-frequency superconductors.
Sexual experiences of postmenopausal women in China: a qualitative study
Authors: Chen Jie , Zhai Haina , Jin Hongyun , Li Xiang , Zhang Pan , Chen Rong
Published: December 2023

Background

Sexual dysfunction is common among postmenopausal women and can have a significant negative impact on quality of life.

Aim

This study aimed to explore perceptions, experiences, and coping strategies related to sex among postmenopausal women in China.

Methods

We used phenomenologic qualitative methods in this study. On the basis of purposive sampling and the data saturation principle, 21 volunteers from a community cohort study were selected for semistructured interviews. The data were analyzed and themes were extracted.

Outcomes

Thematic codes pertaining to sexual experiences and coping strategies were defined and assessed in this study.

Results

Four themes and 12 subthemes were extracted from the interview data. The sexual concepts were relatively conservative for most of the Chinese women; the majority experienced physical and psychological distress with respect to sex, although negative and positive psychological experiences were described. The women often passively accepted and adapted to negative changes to their sex lives during the postmenopause period.

Clinical Implications

This study highlights the importance of and need for effective dissemination of sexual health–related knowledge and the opening of appropriate communication channels.

Strengths and Limitations

By using a qualitative approach, this study provides individuals with the opportunity to describe their cognition and attitudes toward sexuality. Limitations include limited generalizability, as is true for most qualitative research. Additionally, the study is based solely on the female perspective and cannot fully reflect the sex life of couples.

Conclusion

The sexual experiences of our respondents exhibited distinct Chinese cultural characteristics. The interviews show the importance of paying attention to postmenopausal women’s sexual health and providing relevant professional support and guidance to improve women’s overall health-related quality of life.
Physiological and autophagy evaluation of different pear varieties (Pyrus spp.) in response to Botryosphaeria dothidea infection
Authors: Wang Yun , Zhang Ye , Fan Jiaqi , Li Hongxiang , Chen Qiming , Yin Hao , Qi Kaijie , Xie Zhihua , Zhu Nan , Sun Xun , Zhang Shaoling
Published: December 2023

Ring rot disease is one of the most common diseases in pear orchards. To better understand the physiology, biochemistry and autophagic changes of different pear varieties after Botryosphaeria dothidea (B.dothidea) infection, we evaluated eight different pear varieties for B. dothidea resistance. The susceptible varieties had larger spot diameters, lower chlorophyll contents and higher malondialdehyde contents than the resistant varieties. In disease-resistant varieties, reactive oxygen species (ROS) levels were relatively lower, while the ROS metabolism (antioxidant enzyme activities and the ascorbic acid–glutathione cycle) was also maintained at higher levels, and it induced a significant upregulation of related gene expression. In addition, autophagy, as an important evaluation index, was found to have more autophagic activity in disease-resistant varieties than in susceptible varieties, suggesting that pathogen infestation drives plants to increase autophagy to defend against pathogens. In summary, the results of this study reveal that different resistant pear varieties enhance plant resistance to the disease through a series of physio-biochemical changes and autophagic activity after inoculation with B. dothidea. This study provides clear physiological and biochemical traits for pear disease resistance selection, potential genetic resources and material basis for pear disease control and disease resistance, breeding and points out the direction for research on the mechanism of pear resistance to B. dothidea.
La liberté statutaire dans la société par action simplifiée en droit OHADA
Authors: Tchamgwe Innocent
Published: December 2023

A haven for articles of association freedom, in that it constitutes a company tailored to the will of its shareholders, the Simplified Public Limited Company has henceforth imposed itself as a commercial entity whose introduction into the OHADA space has crystallized the contractual design of the commercial company. It allows the partners to freely insert in their articles of association anything that is not expressly prohibited and relating to the constitution, governance, and dissolution of the company. Nevertheless, this exuberant articles of association freedom, which contrasts sharply with the absence of personal liability of the shareholders for company debts, may be detrimental to the interests of the shareholders, the company, and the economy. Mandatory commercial companies’ rules and the general theory of commercial companies then timidly take it upon themselves to try to tame articles of association freedom and correct the defects of the Simplified Public Limited Company. All this heightens the feeling of distrust vis-à-vis articles of association freedom, which, in the absence of serious limitations, enslaves more than it releases.
Can biomarkers help identify sepsis in adults?
Authors: Narasimhan Katherine , D'Acunto Kristin
Published: December 2023

Sepsis is increasing in incidence in the United States and is one of the most common causes of death in hospitalized patients. Sepsis affects different biochemical and immunologic pathways and can present variably. Despite efforts to unify definitions of sepsis, increase awareness, and improve treatment, mortality remains high. Because of sepsis's complex pathophysiology, diagnosis can be challenging. No diagnostic test is sensitive or specific enough to diagnose sepsis in isolation. However, three biomarkers—lactate, C-reactive protein, and procalcitonin—in combination with other diagnostics may help clinicians diagnose sepsis earlier, leading to better patient outcomes.