bluuebunny/crossref_metadata_2025 huggingface dataset:
REVIEW OF MODERN METHODS OF TREATING HYPERTROPHIC AND KELOID SCARS
Authors: Gladko V.V. , Izmaylova I.V.
Published: July 2024

Background. Treatment of hypertrophic and keloid scars is a complex process, that requires interdisciplinary interaction and combined treatment. This article introduces modern data on the etiology and pathogenesis of hypertrophic scars and keloids, provides the main aspects of differential diagnosis and reviews modern treatments methods. Purpose. To acquaint medical specialists with modern methods of diagnosis, differential diagnosis and treatment of pathological cicatricial changes in the skin. Materials and methods. To select the literature, we used the databases as Google Scolar, eLibrary and PubMed for the last 20 years using the search words “hypertrophic scars-keloids.” The review included 48 articles, 37 of which were by foreign authors. Results. Small keloid scars can be treated conservatively. Large scars require complex treatment methods, including surgery and adjuvant therapy due to the high percentage of relapses and unsatisfactory aesthetic results of monotherapy. Conclusions. Despite the wide range of keloid and hypertrophic scar treatment methods currently available, a universal method for treating hypertrophic and keloid scars has not yet been found.
PENGARUH TERAPI DZIKIR TERHADAP PENURUNAN STRES PASIEN DIABETES MELLITUS TIPE 2
Authors: Martadinata Umar Hasan
Published: July 2024

Diabetes Mellitus Tipe II (DMT2) merupakan penyakit kronis dengan prevalensi yang meningkat secara global, mempengaruhi kesehatan fisik dan psikologis pasien. Stres adalah masalah psikologis umum yang memperburuk kontrol glikemik dan meningkatkan risiko komplikasi pada pasien DMT2. Terapi dzikir sebagai intervensi spiritual telah terbukti membantu mencapai ketenangan batin dan mengurangi stres. Penelitian ini bertujuan untuk mengetahui pengaruh terapi dzikir terhadap penurunan stres pada pasien DMT2. Penelitian ini menggunakan desain pra-eksperimen dengan pendekatan pretest-posttest tanpa kelompok kontrol. Sebanyak 30 pasien DMT2 di wilayah kerja Puskesmas Lubuk Batang dipilih menggunakan teknik purposive sampling. Kriteria inklusi meliputi pasien dengan diagnosis DMT2, berusia 40-60 tahun, memiliki tingkat stres ringan hingga sedang, dan bersedia mengikuti terapi dzikir. Kriteria eksklusi meliputi pasien dengan komplikasi akut, gangguan psikiatri, terapi stres lainnya, dan yang tidak bersedia mengikuti prosedur penelitian. Instrumen yang digunakan untuk mengukur stres adalah Perceived Stress Scale (PSS). Analisis data menggunakan uji statistik Wilcoxon. Sebelum terapi dzikir, 74.1% pasien mengalami stres ringan dan 25.9% mengalami stres sedang. Setelah terapi, 88.9% pasien tidak lagi mengalami stres, sementara 11.1% masih mengalami stres ringan. Uji Wilcoxon menunjukkan nilai p sebesar 0.001 mengindikasikan penurunan stres yang signifikan secara statistik. Hasil penelitian ini menunjukkan bahwa terapi dzikir efektif dalam menurunkan tingkat stres pada pasien DMT2. Terapi dzikir secara signifikan menurunkan stres pada pasien DMT2, mendukung integrasi praktik spiritual dalam manajemen diabetes yang holistik. Perawat dapat mengimplementasikan terapi dzikir sebagai bagian dari intervensi perawatan holistik untuk pasien diabetes, dengan memberikan edukasi dan dukungan yang diperlukan untuk praktik dzikir yang efektif.
Carissa carrandas L. and C. spinarum L. – Ignored Nutraceutical Fruits
Authors: C Ahuja, S. , Ahuja Siddharth , Ahuja Uma
Published: July 2024

Carissas (C. carandas and C. spinarum) are natives of India. Duo is evergreen, hard, diffuse and spiny shrub that being highly drought-resistant grows well in semiarid and arid areas, may serve as a wind break and protective hedge. The plants offer multifarious uses in landslide protection and as a live fence, food (direct and processed, beverages, wine, salad, vegetable, jam), fodder, timber, fuel, wood, a green source of dye and diesel, and of sacred value and sorcery. Unripe fruits are used in pickling while ripe ones are edible. People in various states of India, Bangladesh, Myanmar and Pakistan, Kenya, Ethiopia, Senegal and West and South African countries eat raw fruit. Fruit also serves as a spice and a condiment. Known as Karonda (in vernacular language) duo has been used as a folk, veterinary and traditional medicine in the Ayurvedic, Unani, Homeopathic and Chinese and Thai systems. Additionally, duo serves as nutraceutical being rich in iron and vitamins. C. carandas finds place in historical accounts, Ayurvedic and culinary treatises as well in literature and folklore. The multifarious uses of C. spinarum in traditional medicine has earned it epithet as ‘magic tree’ in East Africa. The present paper reviews the history, distribution, folklore, uses as food, forage, feed, folk medicine, and the pharmaceutical, therapeutic, cultural, ecological and nutritional value of Karandas.
Imaging of Gliomatosis Peritonei Following an Immature Ovarian Teratoma: A Case Report
Authors: Bounnite I. , Benamara A. , Ouali A. El , Moussaoui S. , Lebied M. , Mountassir C. , Lembarki G. , Sabiri M. , Lezar S.
Published: July 2024

Peritoneal gliomatosis is defined by the implantation of mature glial tissue on the surface of the peritoneum or intraperitoneal organs, very often found in association with mature or immature teratoma. The report the case of a 23-year-old woman presenting a surgical history of left ovariectomy for immature ovarian teratoma five years prior followed by chemotherapy, presents for abdominal pain for which an abdominal ultrasound and MRI were performed and showed a right hepatic mass in connection with a peritoneal gliomatosis.
The Influence of Coach-Controlled Behavior and Coach-Athlete Relationships on Athlete Engagement
Authors: Liu Shiling , Chen Yingqi
Published: July 2024

Athletes' investment is not only a lasting, positive cognitive and emotional experience in sports, but also an important indicator to measure the positive aspect of athletes, which can effectively avoid psychological fatigue in athletes. Therefore, it is particularly important to explore the influencing factors of the athletes 'investment and to explore the ways to improve the athletes' investment, and for them to give full play to their sports skills steadily in sports training and competition. Results: There were significant negative correlation between coach control behavior and coach-athlete relationship, and between coach-athlete relationship and athlete input. Conclusion: From the above results, the coach control behavior is not conducive to the promotion of athlete input and the establishment of coach-athlete relationship.
Immediate Postoperative Outcome of Peritoneal Lavage with Povidone-Iodine Based Normal Saline Versus Normal Saline in Duodenal Ulcer Perforation
Authors: Kabir Dr. Mohmmad Shahin , Hosain Dr. Md. Yeakub , Reza Dr. Shahin , Hossain Dr. Md. Jakir , Azad Dr. Md. Mahbub , Sultana Prof. Dr. Salma
Published: July 2024

Background: Duodenal ulcer perforation is a common surgical problem, it usually causes peritonitis. Postoperative minor and major complications are common in patients with peritonitis. Intraoperative peritoneal lavage is an important step of operative management and choice of fluid for peritoneal lavage can affect the outcome. Objectives: To compare the immediate post-operative outcome of povidone-iodine based normal saline lavage and normal saline lavage in duodenal ulcer perforation. Methods: This Quasi experimental study intended to compare the immediate post-operative outcomes between povidone-iodine based normal saline versus normal saline lavage in duodenal ulcer perforation. A total of 100 cases of duodenal ulcer perforation underwent laparotomy in Dhaka Medical College Hospital from January 2021 to December 2022, included in this study according to the inclusion and exclusion criteria. Cases were non-randomly allocated to group A (peritoneal lavage with povidone-iodine based normal saline) and group B (peritoneal lavage with normal saline). Each group consisted of 50 patients. The outcome variables were sepsis, wound infection, intra-abdominal abscess, burst abdomen and hospital stay. Data were analyzed and compared by statistical tests. Results: In povidone iodine based normal saline group, there was significant reduction in postoperative wound infection (p=0.042), sepsis (p=0.0414) and hospital stay (p=0.0173). No significant differences were found regarding age (p=0.3466), intra-abdominal abscess (p=0.646) and burst abdomen (p=0.522) between two groups. Conclusion: Povidone-iodine based normal saline lavage was better than only normal saline lavage in duodenal ulcer perforation in terms of wound infection, sepsis and hospital stay.
Pattern of Ocular Morbidity among Children Referred Ophthalmology Dept. at Mugda Medical College Hospital, Mugda, Dhaka, Bangladesh
Authors: zaman Md. Asaduz
Published: July 2024

Introduction: Childhood ophthalmic disorders can seriously impact on development, education, future employment opportunities and quality of life. The consequences are especially severe in low resource settings where resources and education are lacking. Sub-optimal vision can lead to poor academic performance, a lack of interest in school, and even dropping out. Objective: To evaluate the pattern of various ocular morbidities among preschool children. Methodology: This was a cross sectional study conducted among 200 preschool children in the age group between 3 to 6 years at Dept. of Ophthalmology, Mugda Medical College Hospital, Mugda, Dhaka, Bangladesh from January 2022 to December 2023. We excluded children with some other comorbidities and children who were mentally retarded. Vision was assessed with Snellen's visual acuity charts and Kay Picture chart. Anterior and posterior segment examination was done using a hand-held portable slit lamp and a direct ophthalmoscope respectively. Binocularity was assessed with a cover test at a distance and near targets and the Hirschberg corneal reflex. The refractive status of the eyes was assessed by performing static retinoscopy. All the data was analyzed according to sex, age, causes of visual impairment and types of ocular morbidity. Results: Among the total 200 preschool children screened, 86 children were boys and 114 were girls. The prevalence of ocular morbidity was found to be 20.0%. Refractive error was the most common cause of visual impairment which was seen in 14.5% of children. The overall prevalence of myopia, hyperopia, and astigmatism was 7.5%, 4.5%, and 2.0% respectively. The other types of ocular morbidities were strabismus in 1.0%, congenital cataract in 1%, conjunctivitis in 1%, chalazion in 10%, vernal kerato conjunctivitis in 1% and congenital ptosis in 0.5%. Conclusion: The relatively high prevalence of refractive error and occurrence of other ocular morbidities in our studied population suggests that there is a need for a large-scale community-based preschool screening program in Bangladesh so that affected preschool children can be identified early and appropriate treatment can be promptly started.
PENGARUH LINGKUNGAN KERJA, PENDELEGASIAN WEWENANG DAN BONUS TERHADAP KEPUASAN KERJA PEGAWAI BPJS KETENAGAKERJAAN CABANG BATAM
Authors: Hakim Lukman , Mustaqim Mustaqim , Suyatni Suyatni , Nurhadiyanti Nurhadiyanti
Published: July 2024

Penelitian ini bertujuan untuk memperoleh informasi mengenai keterkaitan antara variabel bebas yaitu; lingkungan kerja (X1), pendelegasian wewenang (X2), dan bonus pegawai (X3) dengan variabel terikat yaitu kepuasan kerja pegawai (Y) BPJS Ketenagakerjaan Cabang Batam, baik secara sendiri-sendiri maupun secara bersama-sama. Populasi dari penelitian ini adalah seluruh pegawai BPJS Ketenagakerjaan Cabang Batam yang berjumlah 35 orang.  Dalam penelitian ini tidak diadakan klasifikasi perbedaan pegawai berdasarkan jenis atau status golongan, kedua jenis kepegawaian tersebut mempunyai perlakuan yang sama  Sampel diambil dengan menggunakan teknik simple random sampling (acak sederhana). Dengan menggunakan rumus Slovin diperoleh sampel sebanyak 32 orang. Hasil penelitian menunjukkan terdapat pengaruh positif yang signifikan lingkungan kerja (X1), pendelegasian wewenang (X2), dan bonus (X3) terhadap kepuasan kerja pegawai (Y) yang ditunjukkan oleh nilai Fhitung sebesar 23,247.  Nilai ini jauh lebih kecil dari pada nilai Fhitung pada taraf signifikansi alpha 0,05 yaitu 2,95, atau F = 23,247 < F0,05(3:28) = 2,95.  Pola hubungan keempat variabel yang dinyatakan oleh persamaan regresi ganda  = -6,812 + 0,469X1 + 0,547X2 + 0,278X3.  Sebelumnya berdasarkan uji validitas dan reliabilitas, semua instrumen memenuhi syarat validitas dan reliabilitas.  Jika dihitung per variabel, maka variabel yang paling banyak berpengaruh adalah variabel pendelegasian wewenang yaitu memiliki koefisien determinasi sebesar 52,8%.  Hal ini berarti pendelegasian wewenang merupakan faktor yang paling mempengaruhi kepuasan kerja pegawai.
Anatomy of the abnormal growth in the number of Russian publications in conference proceedings in Scopus
Authors: Косяков Д.В.
Published: July 2024

Представлен детальный анализ потока публикаций с российским участием типа Conference Paper в базе данных Scopus, результаты которого ставят под сомнение некоторые кажущиеся очевидными представления о низком качестве "домашних" конференций, значимости влияния зарубежных "мусорных" конференций и других подозрительных практик на развитие этого феномена.

Many researchers have noted the phenomenon of a rapid increase in the number of publications by Russian researchers in conference proceedings indexed in international databases. This phenomenon is often associated with the general publication pressure caused by the peculiarities of the national science policy and accompanied, among other things, by systemic violations of scientific ethics. The paper provides a detailed analysis of the flow of publications with Russian participation of Conference Paper document type in the Scopus database and related conferences. Its results cast doubt on some seemingly obvious ideas about the low quality of "home" conferences, and make it possible to stumble at the significance of the influence of foreign "garbage" conferences and other suspicious practices on the development of this phenomenon.
A eficácia da liraglutida e da semaglutida no tratamento da obesidade: uma revisão integrativa
Authors: Neves Silva Bruna Morgana , Lazzari Branquinho Paula , Luz Capistrano Brito Yolanda , Ayres Vilela Joana , Barbosa Gabriel Marcos
Published: July 2024

A pesquisa sobre a eficácia dos medicamentos semaglutida e liraglutida no tratamento da obesidade tem como objetivo destacar a funcionalidade desses fármacos para pacientes obesos. O estudo analisa seus mecanismos de ação e o perfil de segurança, além de identificar qual deles é mais eficaz. Trata-se de uma revisão integrativa da literatura, de natureza exploratória e descritiva, com abordagem qualitativa. Foram pesquisados artigos publicados a partir de 2020, em inglês e português, nas bases de dados Science Direct e PubMed. A análise individualizada dos medicamentos revelou que, embora tanto a semaglutida quanto a liraglutida compartilhem o mesmo mecanismo de ação, a semaglutida resulta em maior perda de peso, sendo, portanto, mais eficaz no tratamento da obesidade.
Trajetórias dos Sintomas Depressivos Perinatais e Desfechos Adversos na Gravidez em Pacientes Bariátricas
Authors: Caldas Erica Patricia Ramalho de , Araujo Ana Gabriela , Lopes Sálua Elisandra , Costa Claudiele Maria Mariano , Kuriki Fernanda de Jesus Abrantes , Galvão Anna Caroline Moreira Lima , Felix Gabryella Oliveira , Faletti Camila Barbosa , Sampaio Isabella dos Santos , Dutra Mariana Perin , Reis Victor Hugo Gonçalves Guimarães dos , Rossi Matheus Garcia
Published: July 2024

A depressão perinatal é uma condição prevalente e heterogênea associada a desfechos adversos na gravidez. Compreender as diversas trajetórias dos sintomas depressivos durante a gravidez e suas implicações é crucial para intervenções direcionadas. Objetivo: Esta revisão sistemática e meta-análise teve como objetivo sintetizar evidências de estudos que exploram as trajetórias dos sintomas depressivos perinatais e sua relação com desfechos adversos da gravidez. Métodos: Uma busca abrangente no PubMed e em outras bases de dados resultou em 328 estudos, dos quais 6 foram incluídos. Estudos que empregaram diversas metodologias, incluindo modelagem de mistura de crescimento e análises longitudinais, foram considerados. Resultados: Os achados revelaram trajetórias distintas de sintomas depressivos perinatais, incluindo padrões estáveis baixos, altos antenatais e episódicos. Mulheres que experimentaram piora dos sintomas depressivos durante a gravidez apresentaram maior risco de desfechos adversos, como parto prematuro e complicações neonatais. Conclusão: A identificação de trajetórias heterogêneas de sintomas depressivos perinatais destaca a necessidade de estratégias personalizadas de triagem e intervenção. A identificação precoce e o suporte direcionado adaptado a trajetórias específicas de sintomas são essenciais para melhorar os resultados de saúde materna e infantil.
ADESÃO AO TRATAMENTO NOS PACIENTES DIAGNOSTICADOS COM ARTRITE REUMATOIDE EM UM CENTRO DE ATENDIMENTO ESPECIALIZADO NO OESTE DO PARANÁ
Authors: Bertotti Adrieli , Kavalco Caroline Mayara , Toretta Ana Laura , Dias Anna Julia Wunsch , Melo Danniely Alencar Sandim de , Silva Kaoanna Taynara dos Anjos da , Iacono Natália Regina Vieira
Published: July 2024

A artrite reumatoide é uma doença crônica, incapacitante, inflamatória, progressiva e autoimune que afeta as articulações, a patologia se caracteriza por sintomas como dor, rigidez matinal e inchaço articulatório. A doença ocorre quando o sistema imunológico ataca erroneamente as células saudáveis das articulações causando inflamação crônica, isso acontece pela ativação do sistema imune que está relacionado com o complexo de histocompatibilidade do tipo 2 associado a um gatilho ambiental que pode ser o tabagismo ou a peritonite. Com a ativação da doença, teremos a síndrome da poliartrite crônica simétrica de pequenas articulações que se caracteriza por acometer 5 articulações ou mais, por 6 semanas, bilateralmente, sendo que os locais mais acometidos são as interfalangianas proximais, metacarpofalangianas, pés e punhos. Dessa forma, por ser uma doença de caráter progressivo e crônico, os sinais clínicos terão uma piora com a progressão da doença e isso impacta negativamente a qualidade de vida do portador da patologia reumatológica. Nesse intuito, embora a artrite reumatoide não tenha cura, o tratamento adequado ajuda a controlar os sintomas, diminuir o impacto da doença nas atividades cotidianas e retardar a progressão da patologia. Por isso, é muito importante que o paciente compreenda a complexidade da doença e contribua ativamente com a adesão ao tratamento. Com isso, o objetivo desse estudo é levantar a importância da adequada adesão ao tratamento na Artrite Reumatoide como forma de minimizar os sintomas clínicos, melhorar a qualidade de vida e reduzir a progressão da doença, bem como, identificar a faixa etária e o sexo mais acometido pela doença.
ANÁLISE EPIDEMIOLÓGICA DAS NOTIFICAÇÕES DE ÓBITOS EM ADULTOS JOVENS, POR INFARTO AGUDO DO MIOCÁRDIO, NO BRASIL, NO PERÍODO DE 2019 A 2023.
Authors: Menezes Gabriela Dantas , Azevedo Beatriz Ferreira de , Oliveira Victor Tavares de , Gonçalves Victor Neves , Tavares Dolores , Frota Sarah Nicoly Romualdo , Tulli Maysa Cristina , Freitas Bárbara Elisa de , Castro Analaura Ester Silva de , Higuchi Mayara , Oliveira Leonardo Medeiro , Camarço Maria Gabryella Pereira da Silva
Published: July 2024

INTRODUÇÃO: As doenças cardiovasculares (DCV) são a principal causa de morte no Brasil desde os anos 1960 e globalmente. A Organização Mundial da Saúde (OMS) estima que 17,9 milhões de pessoas morrem anualmente devido a DCV, com uma previsão de 25 milhões de mortes anuais até 2030. No Brasil, o infarto agudo do miocárdio (IAM) é a principal causa de óbito. O IAM é caracterizado por dor intensa no lado esquerdo do peito, podendo irradiar para o braço esquerdo, mandíbula, ombros e outras áreas. Diagnóstico precoce e tratamento adequado pode prevenir mortes, mas não está amplamente disponível devido aos altos custos e à concentração em grandes centros urbanos. OBJETIVO: Analisar a quantidade e as variáveis dos óbitos por infarto agudo do miocárdio no Brasil entre 2019 e 2023 e destacar a persistência da doença no cenário nacional. METODOLOGIA: Trata-se de uma pesquisa epidemiológica, retrospectiva e descritiva, com abordagem quantitativa, a partir dos dados obtidos no Departamento de Informática do Sistema Único de Saúde (DATASUS), realizado mediante dados sobre as notificações de óbitos, no Brasil, por infarto agudo do miocárdio, entre os anos de 2019 a 2023. RESUTADOS E DISCURSSÕES: Entre os anos de 2019 e 2023, houve um aumento no número de óbitos por IAM no Brasil, com uma média anual de 217 casos. Houve crescimento constante ao longo desses anos, passando de 195 óbitos em 2019 para 260 óbitos em 2023. Essa possível elevação na incidência, sugere mudanças nos fatores de risco e a não eficacia das medidas de prevenção e tratamento da doença. O estudo mostrou que 65.3% dos óbitos eram do sexo masculino e 34.7% do sexo feminino, atribuido a isso, a proteção cardiovascular dos hormônios femininos. Em relação as regiões do país, o sudeste concentrou a maior parte dos óbitos (43.1%), seguido pelo Nordeste (25.9%), Sul (16.5%), Norte (7.5%) e Centro-Oeste (7.0%). A diderença entre as regiões pode estar associada as condições socioeconomicas, fatores de risco e estilo de vida. Quanto à faixa etária, foram categorizados da seguinte forma: 15 a 19 anos representaram 2.1% (23 pessoas), 20 a 29 anos foram 6.6% (72 pessoas), e 30 a 39 anos compuseram 15.2% (165 pessoas). Em todas as faixas etárias analisadas, houve um aumento significativo, podendo está associando as mundaças no estilo de vida. Em relação à raça, 27.1% dos óbitos eram brancos, 7.8% pretos, 41.1% pardos, 1.8% amarelos, e 0.1% indígenas. Além disso, 22.0% não informaram sua raça. CONCLUSÃO: Os resultados reforçam a necessidade de políticas de saúde pública que visem tanto à prevenção quanto ao tratamento equitativo das doenças cardiovasculares em diferentes grupos populacionais e regiões do Brasil.
Pengetahuan Tentang HIV/AIDS Pada Siswa Kelas XII di SMA Negeri 1 Waru
Authors: Adlina Dhiyavia Yasmin , Soelistyowati Endang , Joeliantina Anita
Published: July 2024

ABSTRAK
 
Pengetahuan tentang HIV/AIDS dan sikap terhadap kondisi ini sangat penting untuk pencegahan dan pengelolaan penyebarannya. Siswa adalah salah satu kelompok yang rentan terhadap risiko penularan HIV dan memiliki potensi besar untuk menjadi agen perubahan dalam upaya pencegahan. Tujuan penelitian ini untuk mengetahui pengetahuan tentang HIV/AIDS pada siswa kelas XII di SMA Negeri 1 Waru. Jenis penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan cross sectional. Pengumpulan data dengan teknik quota sampling sebanyak 151 siswa. Alat pengumpulan data yang digunakan yaitu kuesioner tentang pengetahuan HIV/AIDS yang disebarkan kepada siswa Kelas XII. Hasil dari penelitian menunjukkan bahwa hampir seluruhnya siswa kelas XII memiliki pengetahuan yang baik, sebagian kecil siswa kelas XII memiliki pengetahuan yang cukup, sebagian kecil siswa kelas XII memiliki pengetahuan kurang tentang HIV/AIDS. Hasil penelitian ini diharapkan membantu dalam mengurangi stigma dan diskriminasi terhadap individu yang hidup dengan HIV/AIDS, serta meningkatkan kesadaran dan perilaku pencegahan di kalangan siswa
 
Kata Kunci : Pengetahuan, Remaja, HIV/AIDS
 
ABSTRACT
 
Knowledge of HIV/AIDS and attitudes towards this condition are essential for the prevention and management of its spread. Students are one of the groups that are vulnerable to the risk of HIV transmission and have great potential to become agents of change in prevention efforts. The purpose of this study was to determine the knowledge of HIV/AIDS among XII grade students at SMA Negeri 1 Waru. This type of research uses descriptive research methods with a cross sectional approach. Data collection using quota sampling technique as many as 151 students. The data collection tool used was a questionnaire on HIV/AIDS knowledge distributed to Class XII students. The results of the study showed that almost all students of class XII had good knowledge, a small proportion of class XII students had sufficient knowledge, a small proportion of class XII students had less knowledge about HIV/AIDS. The results of this study are expected to help in reducing stigma and discrimination against individuals living with HIV/AIDS, as well as increasing awareness and preventive behavior among students.
Efeito Protetor do RNA Não Codificante Longo OXCT1-AS1 na Apoptose de Células Miocárdicas Humanas Induzida pela Doxorrubicina pelo Padrão Competitivo de RNA Endógeno
Authors: Chen Zhen , Liu Yijue , Ma Rui , Zhang Mengli , Wu Xian , Pen Huan , Gui Feng , Liu Yafeng , Xia Hao , Hu Niandan , Ai Bo , Xiong Jun , Xia Hongxia , Li Wenqiang , Ai Fen
Published: July 2024

Resumo Fundamento: O antibiótico quimioterápico antraciclina doxorrubicina (DOX) pode induzir cardiotoxicidade cumulativa e levar à disfunção cardíaca. RNAs não codificantes longos (lncRNAs) podem funcionar como importantes reguladores na lesão miocárdica induzida por DOX. Objetivo: Este estudo tem como objetivo investigar o papel funcional e o mecanismo molecular do RNA antisense lncRNA OXCT1 1 (OXCT1-AS1) na lesão celular miocárdica induzida por DOX in vitro. Métodos: Cardiomiócitos humanos (AC16) foram estimulados com DOX para induzir um modelo de lesão celular miocárdica. A expressão de OXCT1-AS1, miR-874-3p e BDH1 em células AC16 foi determinada por RT-qPCR. A viabilidade das células AC16 foi medida pelo ensaio XTT. A citometria de fluxo foi empregada para avaliar a apoptose de células AC16. Western blotting foi utilizado para avaliar os níveis proteicos de marcadores relacionados à apoptose. O ensaio repórter de luciferase dupla foi conduzido para verificar a capacidade de ligação entre miR-874-3p e OXCT1-AS1 e entre miR-874-3p e BDH1. O valor de p<0,05 indicou significância estatística. Resultados: A expressão de OXCT1-AS1 foi diminuída em células AC16 tratadas com DOX. A superexpressão de OXCT1-AS1 reverteu a redução da viabilidade celular e a promoção da apoptose celular causada pela DOX. OXCT1-AS1 está ligado competitivamente ao miR-874-3p para regular positivamente o BDH1. A superexpressão de BDH1 restaurou a viabilidade das células AC16 e suprimiu a apoptose celular sob estimulação com DOX. A derrubada do BDH1 reverteu a atenuação da apoptose de células AC16 mediada por OXCT1-AS1 sob tratamento com DOX. Conclusão: LncRNA OXCT1-AS1 protege células miocárdicas humanas AC16 da apoptose induzida por DOX através do eixo miR-874-3p/BDH1.
Age, Renal Failure and Transfusion are Risk Predictors of Prolonged Hospital Stay after Coronary Artery Bypass Grafting Surgery
Authors: Andrade Diego Pereira Gregório de , Freitas Fabiane Letícia de , Borgomoni Gabrielle Barbosa , Goncharov Maxim , Silva Pedro Gabriel Melo de Barros e , Nakazone Marcelo Arruda , Campagnucci Valquiria Pelisser , Tiveron Marcos Gradim , Lisboa Luiz Augusto , Dallan Luís Alberto Oliveira , Jatene Fabio Biscegli , Mejia Omar Asdrúbal Vilca
Published: July 2024

Abstract Background: Identifying risk factors in cardiovascular surgery assists in predictability, resulting in optimization of outcomes and cost reduction. Objective: This study aimed to identify preoperative and intraoperative risk predictors for prolonged hospitalization after coronary artery bypass grafting (CABG) surgery in the state of São Paulo, Brazil. Methods: A cross-sectional analysis using data from the REPLICCAR II database, a prospective, consecutive, multicenter registry that included CABG surgeries performed between August 2017 and July 2019. The primary outcome was a prolonged hospital stay (PHS), defined as a postoperative period exceeding 14 days. Univariate and multivariate logistic regression analyses were performed to identify the predictors with significance set at p <0.05. Results: The median age was 63 (57-70) years and 26.55% of patients were female. Among the 3703 patients analyzed, 228 (6.16%) had a PHS after CABG, with a median hospital stay of 17 (16-20) days. Predictors of PHS after CABG included age >60 years (OR 2.05; 95% CI 1.43-2.87; p<0.001); renal failure (OR 1.73; 95% CI 1.29-2.32; p <0.001) and intraoperative red blood cell transfusion (OR 1.32; 95% CI 1.07-2.06; p=0.01). Conclusion: Age >60 years, renal failure, and intraoperative red blood cell transfusion were independent predictors of PHS after CABG. The identification of these variables can help in multiprofessional strategic planning aimed to enhance results and resource utilization in the state of São Paulo.
भारत में धार्मिक सांप्रदायिक हिंसा का विश्लेषणात्मक पद्धति अध्ययन
Authors: Kirti Karothiya  , Dr. Rekha Rani sharma  , Pro. Sanjay Kulshrestha
Published: July 2024

इन संघर्षों को बढ़ावा देने वाले सामाजिक-राजनीतिक और ऐतिहासिक तत्वों पर जोर देते हुए, यह पुस्तक भारत में धार्मिक सांप्रदायिक हिंसा का विश्लेषणात्मक विश्लेषण प्रस्तुत करती है। यह गुजरात में 2002 में हुए दंगों जैसी महत्वपूर्ण घटनाओं की जांच करती है और इस बात पर गौर करती है कि राजनीतिक व्यवस्था, सरकार और चरमपंथी संगठन किस तरह तनाव को बढ़ा सकते हैं। अध्ययन में सामाजिक, राजनीतिक और ऐतिहासिक विश्लेषणों का उपयोग करके सांप्रदायिक हिंसा के तंत्र और अंतर्निहित कारणों की जांच करने के लिए एक बहु-विषयक दृष्टिकोण का उपयोग किया गया है। भारत में संघर्ष समाधान और सांप्रदायिक सद्भाव के संभावित रास्तों के बारे में ज्ञान को आगे बढ़ाने के लक्ष्य के साथ, यह लोकप्रिय आख्यानों पर सवाल उठाता है और इस तरह के विवादों के पीछे के कारणों पर एक महत्वपूर्ण दृष्टिकोण प्रदान करता है।
Relación de la Animación Turística Sociocultural en las Políticas Públicas y en la Competitividad Sistémica de Destinos Turísticos en el Noroeste de México
Authors: Hernández Ponce Oscar Ernesto , López Figueroa José Carlos , Ramos Godínez Claudia
Published: July 2024

El turismo es un sector socioeconómico y ambiental dinámico, a través del cual se puede impactar en el desarrollo sustentable de las regiones. La investigación se realizó para analizar la animación turística sociocultural y su incidencia en la consolidación de las políticas públicas en cuatro regiones del Noroeste de México con potencial turístico para el fortalecimiento de su competitividad. En cuanto a la metodología, se aplicaron un total de 68 cuestionarios en las regiones de San Carlos y Guaymas en Sonora, Loreto en Baja California Sur y Ensenada en Baja California Norte. La investigación tiene un alcance correlacional, se utilizó la estadística inferencial y se usó el software SPSS versión 25. Los principales resultados exponen que existe una relación significativa sobre cómo la animación turística sociocultural incide en la competitividad de los destinos turísticos con 0.572**. Dentro de las conclusiones, se establece que las políticas públicas orientadas al turismo deberían incorporar las herramientas de la animación turística sociocultural, mismas que permiten generar las condiciones para que cada destino turístico sea competitivo.
EFICÁCIA NA INTERVENÇÃO PRECOCE DE CRIANÇAS COM SINAIS DE HIPÓXIA NA EMERGÊNCIA
Authors: Ana Luiza Gonçalves De Oliveira
Published: July 2024

Introdução: Um amplo espectro de condições conhecidas como doenças neuromusculares afetam a função dos nervos periféricos, especificamente neuromusculares e dos músculos . Devido às alterações na resposta muscular, à probabilidade de complicações respiratórias e à sensibilidade a alguns anestésicos, pacientes com essas condições podem enfrentar dificuldades específicas quando se trata de anestésicos. Assim, a anestesia é vital para garantir conforto e dor durante as intervenções médicas, especialmente em doenças neuromusculares, onde a administração adequada e um profundo entendimento da fisiologia muscular e nervosa são necessárias. Objetivo: pesquisar e avaliar protocolos, métodos e soluções para administrar anestesia de maneira segura como também analisar os sinais de hipóxia em pacientes com doenças neuromusculares. Metodologia: As bases de dados Scielo, Medline e Science Direct foram utilizadas para pesquisar artigos publicados em português, inglês ou espanhol. Considerações finais: Os profissionais de saúde podem criar um ambiente anestésico seguro e eficiente para pessoas com doenças neuromusculares ao usar uma abordagem multidisciplinar e manter as práticas clínicas atualizadas com os avanços científicos. Isso leva a uma melhoria na qualidade dos cuidados médicos que recebem nessa situação particular.
PREVALÊNCIA DE SINTOMAS DE ANSIEDADE ENTRE ESTUDANTES DE MEDICINA DE UMA UNIVERSIDADE DO MARANHÃO - BRASIL
Authors: Carvalho Branco Simões Roberta , Almeida Alves Isabela , Miranda Aragão Mónica Andréa
Published: July 2024

Objetivo: Identificar a prevalência de sintomas ansiosos nos estudantes de medicina de uma universidade do maranhão, Brasil. Metodologia: Trata-se de um estudo transversal, com abordagem quantitativa. Foram aplicados, presencialmente, aos estudantes de medicina o Inventário de Ansiedade de Beck. O tamanho da amostra compreendeu 296 alunos. Esses estavam regularmente matriculados no curso e foram selecionados entre o segundo e décimo primeiro período. Resultados: Dos alunos entrevistados, 46,62% apresentavam sintomas mínimos de ansiedade. As mulheres de 18 a 22 anos, 14,28%, se encontravam com o escore grave e os homens da mesma faixa etária, apenas 8,82% eram graves. Conclusão: Observou-se, a maior sintomatologia entre o gênero feminino, e principalmente entre os adultos jovens.
Bacteria Burkholderia sp. y su Relación con las Infecciones Asociadas a la Atención de la Salud.
Authors: Rojas Terrazas María Esther , Guzmán Rojas Khateryn Juliana
Published: July 2024

Introducción: Las infecciones asociadas a la atención de la salud son un desafío global debido a su alta morbilidad, mortalidad y costos. Burkholderia sp. es un patógeno hospitalario relevante por su resistencia a múltiples antibióticos y su capacidad para causar infecciones graves. Esta revisión aborda su microbiología, epidemiología, resistencia, manifestaciones clínicas, control y tratamiento. Metodología: Para esta revisión sobre Burkholderia sp. y su relación con las infecciones asociadas a la atención de la salud, se seleccionaron estudios originales, revisiones, metaanálisis y reportes de casos de revistas científicas revisadas por pares, abarcando epidemiología, microbiología, resistencia, manifestaciones clínicas, control y tratamiento, utilizando bases de datos como PubMed, Scopus, Scielo y Google Scholar. Desarrollo: Burkholderia sp. es un género de bacterias gramnegativas, aerobias y móviles, comunes en el suelo y ambientes acuáticos. Incluye patógenos oportunistas como el complejo Burkholderia cepacia y Burkholderia pseudomallei, que causan infecciones graves y resistentes a múltiples antibióticos en entornos hospitalarios. Su capacidad para formar biopelículas y resistir desinfectantes agrava la situación, subrayando la necesidad de estrictas medidas de control y prevención. Las infecciones varían según la región y factores de riesgo, y su tratamiento requiere combinaciones de antibióticos debido a su alta resistencia. Nuevas investigaciones buscan mejorar las opciones terapéuticas. Discusión: La revisión de la literatura sobre Burkholderia sp. en infecciones asociadas a la atención de la salud (IAAs) resalta su importancia en hospitales por su resistencia a múltiples antibióticos. Estas infecciones complican el tratamiento y aumentan la mortalidad. Se necesitan estrategias rigurosas de control, educación continua del personal, y desarrollo de nuevas terapias.
Nurse Workload with Completeness of Nursing Documentation Model Source Oriented Record during Pandemic Period
Authors: Putri Ryandini Tiara , Lukman Hakim  , Mokhamad Nurhadi  , Mei Widyawati  , Dyah Pitaloka
Published: July 2024

Ensuring Completeness in nursing documentation is highly important as it reflects a  nurse's responsibility and accountability for the tasks performed to meet client needs. However, the heavy workload of Nurses can hinder the implementation of nursing documentation.  This study aims to determine the nurse workload and the completeness of nursing documentation with a source-oriented record model during the pandemic (in the Regional General Hospital dr. R. Koesma Tuban) in 2022. This research method uses a correlational analytical research design that examines whether is a relationship between variables with a cross-sectional approach. The population consisted of all nurses in dr. R. Koesma Tuban Hospital, totaling 320 nurses , with a sample size of 155 respondents selected through simple random sampling technique. The Instruments used in this study included a Self-compassion questionnaire consisting of 11 questions and a documentation completeness questionnaire  including models source-oriented record consisting of 11 questions. This study utilized the Spearman test with a significance level of   = 0.05, the results obtained = 0.02 obtained = 0.02 were less than 0.05, thus accepting the alternative hypothesis (H1). This study concludes that there is a significant correlation between nurse workload and the completeness of nursing documentation with a source-oriented record model during the pandemic in dr. R. Koesma Tuban Hospital in 2022. It is suggested that further research investigate additional causal factors influencing the completeness of the source-oriented record model of nursing documentation.
Optimization of Polymer and Plasticizer Composition in the Formulation of Edible Film Strips Ethanol Extract of Seroja Roots (Nelumbo nucifera Gaerth) as Antioxidant
Authors: Rika Sebtiana Kristantri  , Tris Harni Pebriani  , Ungsari Rizki Eka Purwanto  , Orvala Wilakeyne Dhoffaluthfica
Published: July 2024

Skin aging can occur if endogenous antioxidants are not sufficient to ward off radical compounds and external antioxidant intake is needed. One plant that contains antioxidants is lotus root (Nelumbo nucifera Gaertn.) and has the potential to be developed into nutraceutical products, namely edible film strips. This research aims to develop edible film strips from ethanol extract of lotus roots as anti-aging by optimizing polymer and plasticizer components, namely HPMC and sorbitol using the Simplex Lattice Design method from Design Expert 13.0 software. The antioxidant activity of the preparation was tested using the 1,1-diphenyl-2-picrylhydrazyl method. Phytochemical screening results showed that the extract contained polyphenols, tannins, flavonoids and saponins. The predicted optimal formula for edible lotus root extract has a HPMC-Sorbitol composition ratio of 2:10 with a desirability value of 0.737. Observation results show that the optimum formula preparation has a thickness of 0.32 mm; pH 3.22; drying shrinkage 6.91%; absorption capacity 49.73%; and disintegration time 31.56 seconds. This value is not significantly different from the physical characteristic value predicted by the software (Sig. 2-tailed > 0.05). The potential anti-aging activity which is identical to the antioxidant activity of the optimum formula is shown by obtaining an IC50 value of 58.6174 ppm which is included in the strong antioxidant group. This is thought to be attributed to the presence of tannin and flavonoid polyphenol compounds in the lotus root extract, where these compounds have hydroxy groups which have been proven to be able to capture free radicals.
THE STATE OF GREENHOUSE GAS EMISSIONS IN THE KYRGYZ REPUBLIC AND WAYS TO REDUCE THEM (ON THE EXAMPLE OF VEHICLES)
Authors: Ashiraliev Abdiumamatkadyr ,   Doctor of Technical Sciences, Associate Professor, Professor of the Department of Electrical Power Engineering and Mechanics, JalalAbad State University named after B. Osmonov, JalalAbad, Kyrgyzstan, Kokumbaeva Kulumkan A. , Turdukulova Aisulu A. , Sultanalieva Kumushay K. , Kochkorova Mahabat B. ,   Candidate of Technical Sciences, Associate Professor, Associate Professor of the Department of Electrical Power Engineering and Mechanics, JalalAbad State University named after B. Osmonov, JalalAbad, Kyrgyzstan,   Senior Lecturer of the Department of Electric Power Engineering and Mechanics, JalalAbad State University named after B. Osmonov, JalalAbad, Kyrgyzstan,   Senior Lecturer of the Department of Electric Power Engineering and Mechanics, JalalAbad State University named after B. Osmonov, JalalAbad, Kyrgyzstan,   Lecturer of the Department of Electric Power Engineering and Mechanics, JalalAbad State University named after B. Osmonov, JalalAbad, Kyrgyzstan
Published: July 2024

The main cause of global warming and climate change is the release of greenhouse gases (GHGs) into the Earth's atmosphere. Different countries around the world emit different amounts and compositions of greenhouse gases. This article aims to clarify the places of the Kyrgyz Republic in terms of GHG emissions and to identify the main types of sources. We analyzed the system for collecting statistical data in the Kyrgyz Republic on climate change indicators. Indicators have been identified where the methodology has been approved at the national level, for which statistical data are regularly published. Kyrgyzstan's Nationally Determined Contributions (NDCs) set targets for unconditional reductions in greenhouse gas emissions for 2025–2030. The level of greenhouse gas (GHG) emissions in Kyrgyzstan is relatively low. This is due to the fact that one type of energy generating stations predominates in the country – hydroelectric power plants (HPPs). However, in Kyrgyzstan, the energy system takes first place, and the road transport system takes second place, emitting a significant amount of GHGs. The article analyzes ways to reduce the volume of GHGs emitted by the motor transport industry of Kyrgyzstan.
MODELING AND PROSPECTS FOR THE DEVELOPMENT OF WINEMAKING IN THE RUSSIAN FEDERATION
Authors: Tugushi Veronika A. ,   Plekhanov Russian University of Economics, Moscow, Russia
Published: July 2024

Currently, the following key trends can be identified in the field of viticulture and winemaking: a decrease in land plots on which grapes are grown, a reduction in production activity, and a decline in consumer demand. The presented article conducts a study of the field of domestic winemaking for 2022–2023. Special regions of great importance in winemaking activities are identified, and the possibilities for industry development are analyzed. The main goal of the article is to implement analytical work in the winemaking industry, special attention is paid to the main parameters that can reflect the situation and dynamics of industry development: the amount of consumption, production volumes, etc. Models for specification of grape harvest and yield for 4 years in 8 federal districts of Russia are proposed. A wide range of methods was used to assess the gross harvest: comparison to study dynamics, statisticaleconomic and abstractlogical methods to fill in the theoretical analysis. Modern Russian winemaking receives quite a lot of support from the state, while sanctions from foreign countries began to stimulate growth, and consumers were faced with the need to become familiar with the intricacies of domestic winemaking.
PRIORITIES FOR THE DEVELOPMENT OF THE KARABAKH AND EAST ZANGEZUR ECONOMIC REGIONS OF AZERBAIJAN
Authors: Magerramov Eldeniz Mazakhir ogly ,   Azerbaijan Cooperation University, Baku, Republic of Azerbaijan
Published: July 2024

The article defines the priorities for the development of the agricultural sector of the Karabakh and East Zangezur economic regions of Azerbaijan. The processes of restoration and development of the agricultural sector in post-conflict territories are analyzed. The role of newly created economic regions in these processes is considered. In the Karabakh and East Zangezur economic regions, factors that positively influence the development of the agricultural sector are brought to the fore. Attention was paid to the directions of development of agricultural sectors and livestock farming. In the region, attention is focused on increasing grain production, especially food wheat. An assessment was made of the availability of additional resources to build industrial capacity. Based on the priorities for the development of economic regions, the directions for intensifying the development of the agricultural sector in Karabakh and Eastern Zangezur were substantiated and a number of proposals were put forward.
INTRODUCTION TO TRIGGER OF MONETARY CIRCULATION AND PRINCIPLES OF QUANTITATIVE EASING
Authors: Babayev Chingiz A. ,   Company “Caspianproservice”, Baku, Republic of Azerbaijan
Published: July 2024

The main objectives of this study are: • comparison of quantitative easing ideas and actual practice; • consideration of QE factors for Trigger of Money Circulation in comparison with an ideas and goals of QE by Richard Werner. The paper presents justifications: • area of definition and limits of the monetary aggregate-trigger which is a generator of GDP; • changes in the money supply with a constant Trigger do not affect inflation/deflation and GDP.
RECENT MARKET ANALYSIS OF PLANT PROTEIN-BASED MEAT ALTERNATIVES AND FUTURE PROSPECT
Authors: Samad A , Kumari S , Hussain Md. J. , Alam A. M. M. Nurul , Kim Soe-Hee , Kim Chan-Jin , Lee Eun-Yong , Hwang Young-Hwa , Joo Seoon-Tee
Published: July 2024

Food shortage is a primary challenge as the human population is increasing rapidly. Therefore, the world is looking for ways to establish sustainability in the food system to generate nutritious food with better sensory qualities. To fulfill the animal protein requirements of the world, different meat alternatives are available in the market, like cultured meat, mycoprotein, and insects, but from a sustainable point of view, plant-based meat alternatives are the most suitable. However, in producing these alternatives, industrialists need to be aware of particular challenges and opportunities in production and marketing while manufacturing. The major challenge for industrialists is the consumer acceptance rate, which depends on plant-based products' physical appearance and taste. They can improve the marketing of plant-based meat products by improving plant-based meat alternatives' physical and sensory characteristics. The focus of this paper is to discuss the technologies necessary for the production of plant-based meat alternatives. The current findings suggest that the market scenario will change for plant-based meat producers, in which customer preference and beliefs will have a massive role in the acceptance and marketing of this meat. The development of plant-based meat alternatives is the first step to achieving the goal of sustainable food; more innovations are needed to establish a healthier and sustainable food system as this type of food has a low carbon footprint compared to other products available.
Keywords: Plant-based meat, sustainability, food shortage, consumer preference, opportunities, challenges.