bluuebunny/crossref_metadata_2025 huggingface dataset:
Risks and Prospects of Creativity Tokenization
Authors: Budnik R. A.
Published: August 2023

Objective: tokenization of creativity, alongside with cryptoeconomy and Web3 network infrastructure, is a notable trend in the development of modern society in the third decade of the 21st century. The objective of this article is to explore the risks and prospects emerging in the process of disposition of the creative labor results in the form of non-fungible tokens.

Methods: the research methodology is based on analysis of varied viewpoints on the problem, including diametrically opposing concepts. The opposing views of the observers manifest their attitude to tokenization of creative products as a speculative scheme, on the one hand, and a promising tool of creative industries development, on the other.

Results: the probable negative consequences of tokenization of intellectual activity results are identified; author’s recommendations on managing these risks are given. Another result of this publication is analysis of economiclegal prospects stemming from tokenization of the objects of copyright and neighboring rights by the example of musical pieces.

Scientific novelty: it consists in presenting and substantiating a hypothesis that the relations formed in the musical industry under the modern sociocultural and technological realities will be reproduced in other creative industries. Also, scientific novelty consists in the analysis of prospects of tokenization of such results of intellectual activity as gaming artifacts, works of traditional and digital visual arts, patents and scientific achievements. The use of nonfungible tokens the ecosystem of network computer games will allow gamers to buy and sell rights to game pieces autonomously from game publishers. Tokenization of industrial property objects and individualization means will ensure protection of intellectual rights of their authors while waiting for the issuance of a state protection document. In the modern society, there will be many of those wishing to become an owner of a token for a scientific work, as the popularity of science and innovations is constantly growing in developed countries. Ownership of a token for a scientific work will be regarded a moral investment, increasing the prestige and status of its owner. Tokens for scientific works have a high potential as a means of measuring value in a post-economic society.

Practical significance: it consists in the description of innovative means of using creative products and business models based on tokenization of the results of intellectual activity, ready to be implemented in practice.
Human Interpreters in Virtual Courts: A Review of Technology-Enabled Remote Settings in Australia
Authors: Ran Y.
Published: August 2023

Objective: This interdisciplinary review intends to inform legal scholars, practitioners, and users of language interpretation services in the judiciary of challenges encountered by professional interpreters in virtual hearings and remote settings.

Methods: Situated at the intersection of law, language, and communication, this review analyses the latest discourses about technology-enabled remote settings and synthesises insights into recommended practices in effective legal communication mediated by interpreters in virtual courts.

Results: With an overarching aim to improve effective collaboration between interpreting service providers and users in multilingual legal communication for procedural equity and access to justice, this review establishes three central claims: (1) the technology-enabled virtual hearings is accelerated by the covid-19 pandemic, (2) the need for effective legal communication mediated by the use of interpreters in remote settings is mounting, and (3) successful collaboration between the service user and provider can achieve a win-win outcome.

Scientific novelty: A review of existing studies in law and language reveals three main gaps: (1) procedural justice in videoconferencing hearings and remote technologies, (2) equity and access for people with limited proficiency in the official language of the court system, and (3) effective legal communication mediated by human interpreters in virtual courts. This review bridges the existing gaps in knowledge.

Practical significance: it touches on three aspects of the law-language nexus: (1) Covid-19 accelerated adoption of the virtual courtroom technologies in Australia and its impact on court interpreting, (2) challenges for interpreters in remote settings, and (3) achieving linguistic accuracy and intercultural appropriateness when preserving the manner in which the content is expressed as intended or implied by the original speaker. Grounded in courtroom interpreting practices, it highlights the importance of effective collaboration in successful multilingual legal communication rooted in mutual purpose, shared expectations, and interprofessional understanding.
“Smart Cities”: Legal Regulation and Potential of Development
Authors: Tikhaleva E. Yu.
Published: August 2023

Objective: to research the trends of development of the “smart cities” concept and their legal regulation.

Methods: general scientific (induction, deduction) and special (systemicstructural, comparative-legal analysis) methods were used. Also, review analysis was applied to analyze the status quo of “smart cities”. Innovative research approaches are still rare in considering the “smart cities” concept, as well as the prospects referring to targeted knowledge management and cooperation between the respective stakeholders. As for the special research methods for studying digital relations, we used content analysis (the method of creating reproducible and substantiated conclusions from texts (or other meaningful materials) in the context of their use). As the results of previous research and concepts referring to “smart cities” are available, we also used deductive content analysis.

Results: a characteristic is given to public relations formed within the process of development of “smart cities” concept. The key legal acts, principles of formation and functioning of “smart cities” are identified, taking into account the Russian and foreign experience. In this connection, the examples of successful practices are given, of the activities of both Russian and foreign municipal entities, taking into account the competitions held and rankings determined by the central structures. The popular directions are summarized, which are broadly introduced at the local level, and the probable problems are identified in the sphere of implementation of this project in our state.

Scientific novelty: the article carries out an analysis of the current legal regulation and the results of introducing the “smart cities” concept. The promising technologies and methods are identified, which are necessary to achieve the tasks of the concept implementation. The elements are specified, which ensure sustainability of “smart cities” complying with the future demands. An author’s position is expressed regarding a close interrelation of this phenomenon with the institute of local self-government in the context of possible development of the latter into the process of making managerial decisions involving artificial intelligence. This concerns, first of all, using the potential of the Internet of Things. In practice, a lot of problems occur, associated with the implementation of normatively stipulated provisions, which implies the need to perform further research in the sphere under study.

Practical significance: is due to the insufficient development of data about the features and prospects of introducing the idea of “smart cities”. The provisions of the research performed will allow effectively improving the mechanisms of legal regulation and broad implementation of the concept under study.
An efficient implementation of novel Polar encoder with Wavelet pipelining Architecture for 5G Networks
Authors: A Albert Raj , ebenezer vijila , A Calin , D Subbulekshmi
Published: August 2023

The polar code is one of the error correcting codes which was proposed by Dr. Arıkan It attracts the attention of researchers due to the capacity achieving algorithms over a wide range of channels. However polar codes sacrifices encoding complexity and latency to improve error performance. To address this issue, wave pipelining is proposed in this article. The main advantage of pipelining is parallelism which leads to the improvement in latency. In addition, the system gets the benefit of the increased computation rate, or throughput. The absence of registers at the intermediate stages in the wave pipeline makes the polar code more power efficient and efficient area overheads. It provides a method for significantly reducing clock by keeping the external functionality and timing of any circuit. This architecture is coded in VHDL language and the design is synthesized in SYNOPSYS tool and implemented in the Virtex-7 VC 709 FPGA device. The synthesis report proved that 50 % of efficiency in area and timing in the wave pipelining compared to the conventional methods.
Food Diversity, Children Health and the Economic Burden
Authors: Hasanah Alfiah , Kharisma Bayu , Remi Sutyastie S , Adam Asep Muhammad , Siregar Adiatma YM
Published: August 2023

Background This study investigate the impact of low food diversity on the health status of children using Dietary Diversity Score (DDS) and Dietary Serving Score (DSS) in a sub-district with the highest percentage of poor households. The economic burden of low food diversity is observed by analysing cost of illness of the children with low food diversity. Methods Data from 329 children are collected. We determined the impact of DDS and DSS and other factors to the health status of children age 2–14 yo using probit model. The cost of illness (e.g. typhus, stomach ulcers, coughs, flu, and fever) due to low food diversity is calculated from medical registration fees, medical action costs, transportation costs, and other costs. Results The results shows that a 1 percentage point increase of DDS or DSS potentially decreases children health complaints by 10 and 8 percent. Given the current 26 percent prevalence of health complaints among children with low DDS, the economic burden reaches US$75.72. On the other note, the current 41 percent prevalence of children with low DDS resulted in US$153.45 per children. Conclusions The effect of inadequate dietary diversity is potentially high on children health and contributes to economic burden for households and the government.
Associations of Two Psychotic Disorders with Constipation: A Mendelian Randomization Study
Authors: Liu Jiali , Huang Ye-bao , Chen Xiaopin , Qian Hai-hua , Zhang Dan
Published: August 2023

Background: Psychiatric disorders have been associated with Constipation in observational studies, although their causal relationships remain uncertain. We used Mendelian randomization analysis to infer causality between Psychiatric disorders and Constipation.
Methods: The exposure of interest was Psychiatric disorders(Schizophrenia(SCZ) and Major Depressive Disorder(MDD)). Summary statistics for psychiatric disorders were recruited from the PGC, SCZ (30,490 cases and 312,009 controls), MDD (170,756 cases and 329,443 controls), whereas Constipation summary genetic data were obtained from a FinnGen involving 17,246 cases and 201,546 controls. The inverse variance weighted (IVW) method was used as the primary analysis to assess the causal relationship between Psychiatric disorders and Constipation.
Results: LDSC indicated that Constipation are genetically correlated Psychiatric disorders (rg range: |0.04–0.05). The Mendelian randomization analysis indicated that there was significant evidence that genetically determined SCZ ( OR= 1.05, 95% CI =1.02 to 1.07, P＜0.01) and MDD( OR= 1.21, 95% CI =1.10 to 1.33, P＜0.01) were significantly causally associated with the risk of the Constipation.
Conclusion: The Mendelian randomization analysis suggested that SCZ and MDD increase the risk of Constipation.
Equivalent modulus of nanoporous materials based on Steigman-Ogden surface model
Authors: Zheng Chenyi , Li Gaohui , Zhang Mengjie , Jiang Yali , Wang Hongzhen , Li Zhengliang , Sun Mengcheng , Zheng Haolei
Published: August 2023

The work of this paper mainly includes two parts. The first part is to simplify the stress boundary equation of the complex Steigmann-Ogden surface model expressed by the surface gradient operator in spherical coordinates to the stress boundary equation expressed by the spatial gradient operator according to the surface projection tensor. This simplification can directly substitute the complex formula into the fingermark method and directly calculate it into the sizeable mathematical calculation software. In the second part, based on the Mori-Tanaka hole model, the displacement field is decoupled into a hydrostatic and partial displacement field. Based on the homogenization approach, the equivalent elastic modulus of nanoporous materials is solved by satisfying the displacement boundary equation on the boundary of the representative volume element (RVE). The hydrostatic displacement field corresponds to the macroscopic equivalent bulk modulus, while the offset displacement field corresponds to the macroscopic equivalent shear modulus. Finally, this paper conducted auspicious numerical experiments on various surface elastic parameters and explored their control mechanisms. The research in this paper can provide a theoretical basis for designing and manufacturing nanoporous materials.
Management of giant left atrial thrombus late after Transcatheter Mitral Valve-in-ring Replacement using a Transcatheter Aortic Valve
Authors: Maloku Aurel , Hamadanchi Ali , Bargenda Steffen , Richter Markus , Möbius-Winkler Sven , Schulze Christian , Franz Marcus
Published: August 2023

In symptomatic high-risk patients with severe mitral valve regurgitation (MR), who are not eligible for surgery due to multimorbidity, and further do not fulfill the criteria for a Transcatheter edge-to-edge repair procedure (TEER, e.g., using the MitraClip™ system), transcatheter mitral valve replacement (TMVR) may be considered (IIb C) according to current guidelines. Since patients with severe MR due to failing biological mitral valve prostheses are never eligible for TEER and patients after surgical mitral valve repair are sometimes not eligible for TEER, TMVR using transcatheter aortic valve prosthesis has been successfully performed in smaller patient cohorts using both, the transapical as well as the transvascular access route. Due to that limited experiences and outcome data, there is currently no guideline recommendation for these special situations.
Circular RNA CDR1as/ciRS-7-- A Novel Biomarker in Solid Tumors
Authors: Zhang Yun , Kang Zhiqiang , Zhao Tang , Zhang Qiu , Pu Feng , Xu Zihan , Zhao Xinhao , Fu Qiang , Yang Hongji , Wang Haizhen , Zhou Yu , Zhu Shikai
Published: August 2023

Background
Circular RNA CDR1as/ciRS-7 has been reported to function as an oncogenic regulator in various cancers. However, the prognostic value of CDR1as/ciRS-7 expression in solid tumors remains unclear. Herein, we conducted an updated meta-analysis to investigate the association between CDR1as/ciRS-7 expression and clinical outcomes in solid tumors.
Methods
A systematic search was performed through the PubMed, EMBASE, Web of Science, Ovid, Cochrane library, CNKI and WanFang databases for eligible studies on clinical values of CDR1as/ciRS-7 in solid tumors. The pooled hazard ratios (HRs) or odd ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the correlation between CDR1as/ciRS-7 and clinical outcomes.
Results
A total of 2342 patients from 16 studies between 2017 and 2023 were included. The results suggested that elevated CDR1as/ciRS-7 expression predicted a poor OS for 12 types of solid tumors (HR = 1.90, 95% CI: 1.40–2.59, P < 0.001) with no heterogeneity (I2 = 80.9%, P < 0.001). Stratified analysis indicated that there was a negative relationship between CDR1as/ciRS-7 expression and OS in digestive system cancers (HR = 2.28, 95% CI: 1.81–2.88, P < 0.001), and respiratory cancers (HR = 2.40, 95% CI: 1.75–3.30, P < 0.001). Furthermore, we also revealed that CDR1as/ciRS-7 was positively related to tumor size (OR = 2.11, 95%CI: 1.64–2.71, P < 0.001), TNM stage (OR = 2.05, 95%CI: 1.65–2.54, P < 0.001), lymph node metastasis (LNM) (OR = 1.74, 95%CI: 1.38–2.21, P < 0.001), and distant metastasis (OR = 2.79, 95%CI: 1.71–4.55, P < 0.001). Although the probable evidence of publication bias was found in the studies with OS, tumor size, TNM stage, and LNM, the trim and fill analysis confirmed the reliability of these results was not affected.
Conclusion
Elevated CDR1as/ciRS-7 expression was associated with larger tumor size, advanced TNM stage, worse LNM, distant metastasis, and shorter OS, suggesting that CDR1as/ciRS-7 may act as an independent prognostic biomarker in solid tumors.
Robust Bioprocess Design and Evaluation of Commercial Media for the Serial Expansion of Human Induced Pluripotent Stem Cell Aggregate Cultures in Vertical-Wheel Bioreactors
Authors: Borys Breanna S. , Dang Tiffany , Worden Hannah , Abraham Brett D. , Gysel Emilie J. , Malinovska Julia , Larijani Leila , Krawetz Roman , Revay Tamas , Argiropoulos Bob , Rancourt Derrick E. , Kallos Michael S. , Jung Sunghoon
Published: August 2023

Background: While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of PSCs require large cell quantities to be generated under highly robust, well-defined, and economically viable conditions. Small-scale and short-term process optimization, however, is often performed in a linear fashion that does not account for time needed to verify the bioprocess protocols and analysis methods used. Design of a reproducible and robust bioprocess should be dynamic and include a continuous effort to understand how the process will respond over time and to different stresses before transitioning into large-scale production where stresses will be amplified.
Methods: This study utilizes a baseline protocol, developed for the short-term culture of PSC aggregates in Vertical-Wheel® bioreactors, to evaluate key process attributes through long-term (serial passage) suspension culture. This was done to access overall process robustness when performed with various commercially available media and cell lines. Process output variables including growth kinetics, aggregate morphology, harvest efficiency, genomic stability, and functional pluripotency were assessed through short and long-term culture.
Results: The robust nature of the expansion protocol was demonstrated over a six-day culture period where spherical aggregate formation and expansion were observed with high-fold expansions for all five commercial media tested. Profound differences in cell growth and quality were revealed only through long-term serial expansion and in-vessel dissociation operations. Some commercial media formulations tested demonstrated maintenance of cell growth rates, aggregate morphology, and high harvest recovery efficiencies through three bioreactor serial passages using multiple PSC lines. Exceptional bioprocess robustness was even demonstrated with sustained growth and quality maintenance over 10 serial bioreactor passages. However, some commercial media tested proved less equipped for serial passage cultures in bioreactors as cultures led to cell lysis during dissociation, reduction in growth rates, and a loss of aggregate morphology.
Conclusions: This study demonstrates the importance of systematic selection and testing of bioprocess input variables, with multiple bioprocess output variables through serial passages to create a truly reproducible and robust protocol for clinical and commercial PSC production using scalable bioreactor systems.
Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber
Authors: Neto Jose Xavier , Santos Luana Nunes , Costa Angela Maria Sousa , Nikolov Martin , Carvalho João , Sampaio Allysson Coelho , Stockdale Frank , Castillo Hozana Andrade , Grizante Mariana Bortoletto , Dudczig Stefanie , Vasconcelos Michelle , Rosenthal Nadia , Jusuf Patricia , Nim Hieu , Lopes-de-Oliveira Paulo , Matos Tatiana Guimaraes de Freitas , Nikovits William , Schubert Michael , Ramialison Mirana
Published: August 2023

Optimal cardiac function requires appropriate contractile proteins in each heart chamber. Atria require slow myosins to act as variable reservoirs, while ventricles demand fast myosin for swift pumping functions. To achieve this functional distribution, myosins are thus under chamber-biased cis-regulatory control, with a failure in proper regulation of myosin genes leading to severe congenital heart dysfunction. However, the precise regulatory input leading to cardiac chamber-biased expression remains uncharted. To address this, we computationally and molecularly dissected the quail Slow Myosin Heavy Chain III (SMyHC III) promoter that drives preferential gene expression to the atria to define the regulatory information leading to chamber expression and understand its evolutionary origins. We show that SMyHC III gene states are autonomously orchestrated by a complex Nuclear Receptor Element (cNRE), a 32-bp DNA sequence with hexanucleotide binding repeats. Using in vivo transgenic assays in zebrafish and mouse models, we demonstrate that preferential atrial expression is achieved by a combinatorial regulatory input composed of atrial activation motifs and ventricular repression motifs. Using comparative genomics, we provide evidence that the cNRE might have emerged from an endogenous viral element, most likely through infection of an ancestral host germline. Our study hence reveals an evolutionary pathway to cardiac chamber-specific expression.
Factors Predicting Psychological Well-Being Among Survivors of Breast Cancer
Authors: Singtaweesuk Nuntana , Thanoi Wareerat , Vongsirimas Nopporn , Kesornsri Sirada , Klainin-Yobas Piyanee
Published: August 2023

Background
Breast cancer is the most common cancer diagnosed in women with health problems. Studies showed that breast cancer affects women’s mental health and lifestyle after receiving treatment. This study aimed to investigate four key factors (stress, social support, self-efficacy, mindfulness, and resilience) influencing psychological well-being among breast cancer survivors.
Methods
A predictive descriptive research design was conducted and guided by the resilience framework. Eligible criteria included breast cancer survivors receiving care at an outpatient clinic in a tertiary hospital. A convenience sampling was utilized and data were collected by self-administered questionnaires. Data analyses included univariate statistics and multiple linear regression.
Results
Totally, 123 participants were recruited. Stress, social support, and resilience explained 43% of the variance in psychological well-being among breast cancer survivors. Resilience (=.33), stress =-.27), and social support=.26) were significant predictors of psychological well-being and resilience was the strongest predictor.
Conclusions
Psychological factors related to post-disease wellness should be incorporated into interventions. Behaviors that promote resilience and social support and decrease stress levels should be incorporated into activities and programs to enhance breast cancer survivors’ psychological well-being in the future.
Characterization and Pathogenicity of Botryosphaeriaceae Species Associated with Trunk Canker, Gummosis and Dieback of Almond Trees in Turkey
Authors: endes ali , Keles Hakan , Güney Müjgan
Published: August 2023

Turkey is one of the leading almond countries in the world. Almond is a precious nut highly regarded in modern diets due to its bioactive compounds associated with health benefits and disease treatment. However, the yield of plant is affected by several factors, including pathogens. This study aimed to diagnose and identify biotic factors responsible for decline, dieback, and gummosis observed in almond trees in Yozgat province with a temperate climate. A thorough investigation was conducted in seven almond orchards and samples were collected from trees displaying aforementioned symptoms. The isolated species were cultured in PDA medium to identify the morphological and cultural characterization. The results obtained with cultural and morphological characteristics along with Phylogenetic analysis of ITS, β-tubulin, and EF-1α sequence data, confirmed the presence of Diplodia seriata, Lasiodiplodia theobromae, Neofusicoccum parvum, Botryosphaeria dothidea. Among these species, Botryosphaeria dothidea was first reported from almond trees in Turkey. Pathogenicity testing showed that although all species were virulent, L. theobromae and N. parvum isolates caused more gumming in the inoculation areas than D. seriata and B. dothidea isolates. These results confirmed that multiple species of Botryosphaeriaceae family are linked to branch decline and dieback on almond in Turkey, aligning with similar studies conducted on woody crops. Accurate diagnosis of fungal pathogens in almonds is vital for developing effective disease management strategies and may contribute to enhancing horticultural practices for the maintaince of urban almond stands.
Pulmonary Artery Sarcoma effecting the Pulmonary Valve diagnosed as pulmonary vasculitis: a case report and comparative literature review
Authors: Smith Harry James , Al-Zubaidi Fadi , Sitaranjan Daniel , Chiu Steven , Jenkins David
Published: August 2023

Pulmonary arterial sarcomas (PAS) are rare aggressive tumours occurring mainly in the pulmonary trunk. We report a case of pulmonary sarcoma incision involving the pulmonary trunk wall and valve, with uniform thickening which represents an atypical imaging manifestation of this tumour. A 63-year-old male presented with vague respiratory symptoms with rapid progression. CTPA showed low density filling defects in both pulmonary arteries and PET scan showed increased uptake in the pulmonary trunk, which along with raised ESR suggested Pulmonary Vasculitis. Echo imaging showed Right ventricular hypertrophy and pulmonary stenosis. Response to steroid therapy was minimal and his symptoms worsened. A referral for second opinion was made and he was diagnosed with Pulmonary artery sarcoma. He underwent Pulmonary thromboendarterectomy with Pulmonary valve replacement. Post-operative histopathology confirmed the diagnosis. PAS is rare and frequently misdiagnosed. Due to no formal management guidelines, we need to improve our understanding of PAS to improve treatment.
Factors associated with withholding of invasive mechanical ventilation in the early phase of the COVID-19 response and their ethical analyses
Authors: Morioka Shinichiro , Takashima Kyoko , Asai Yusuke , Suzuki Tetsuya , Nomoto Hidetoshi , Saito Sho , Suzuki Kumiko , Suzuki Setsuko , Sato Lubna , Nakamura Keiji , Nikaido Mio , Matsunaga Nobuaki , Hayakawa Kayoko , Mori Masanori , Yamamoto Keiichiro , Ohmagari Norio
Published: August 2023

Background
End-of-life decision making regarding invasive mechanical ventilation (IMV) for patients with severe coronavirus disease (COVID-19) is challenging. We aimed to explore the factors associated with the withholding of IMV in patients with COVID-19.
Methods
This retrospective study included patients registered in a nationwide COVID-19 Registry Japan. We enrolled patients with COVID-19 admitted between January 1, 2020, and June 30, 2021, and died during hospitalisation. The enrolled patients were divided into two groups: those who received IMV (IMV group) and those who did not (non-IMV group). To identify the factors associated with withholding of IMV among patients with COVID-19 who died during hospitalisation, we conducted a multivariate logistic regression analysis.
Results
A total of 2401 patients were enrolled. Of these, 588 (24.5%) were in the IMV group and 1813 (75.5%) in the non-IMV group. Withholding IMV was positively associated with older age (95% confidence interval [CI]: 0.82–0.88, p < 0.0001), dementia (95% CI: 0.81–0.91, p < 0.0001), chronic lung disease (95% CI: 0.88–1.00, p = 0.036), and malignancy (95% CI: 0.82–0.94, p < 0.0004) although inversely associated with male sex (95% CI: 1.04–1.15, p = 0.0008), body mass index (95% CI: 1.01–1.02, p < 0.0001), and National Early Warning Score (95% CI: 1.01–1.03, p < 0.0001).
Conclusions
We explored factors associated with the withholding of IMV and analysed the results to prepare for future emerging infectious disease pandemics by taking a retrospective look at the decision-making process during the COVID-19 disaster and considering multidisciplinary collaboration.
Profiling and bioinformatics analysis of differentially expressed circRNAs in endometrium of patients with recurrent implantation failure
Authors: Zhang Lili , Tian Yu , Gao wenxin , Mi Shengyan , Cao Ying , Liu Siming , Yuan Xiaoye , Xie Yuping , Ma Xiaoling , Wang Jing , Liu Lin
Published: August 2023

Background. Circular RNAs (circRNAs) play crucial roles in many human diseases. However, the role of circRNA in recurrent implantation failure (RIF) remains unclear.
Methods. In order to explore the mechanism of circRNAs in RIF, circRNA expression profiling in endometrial tissue from RIF patients was performed by RNA sequencing (RNA-seq). The expression of differently expressed circRNAs (DEcircRNAs) was verified using GEO database.
Results. Significantly differentially expressed 46 circRNAs were identified (fold change (FC) ≥ 2 and p value < 0.05)and subjected to functional enrichment analysis.Among them, 18 circRNAs were up-regulated and 28 were down-regulated. Moreover, ceRNA network was constructed, which contains 10 circRNAs, 30 miRNAs and 104 mRNAs. Key pathways hsa_circ_0001358-hsa-miR-335-3p-SOSC3/MDM2 and hsa_circ_0072697-hsa-miR-3150a-3p-PFN1 axis were found in the ceRNA network.
Conclusions. These two pathways found in the network may provide novel insights to the underlying pathogenesis of RIF and provide new potential molecular targets for subsequent clinical diagnosis and treatment.
Optimization of Birefringence and single channel elliptical PCF polarisation filter based on surface Plasmon resonance using 2D FDTD method
Authors: Nilu Nilambar Muduli , nilu nilambar Muduli , surya JSN Achary
Published: August 2023

Effect on high birefringence gold coated elliptical PCF polarisation filter based on SPR is investigated in details. The proposed elliptical PCF have 3 air hole ring of different dimension arranged in a specific mode potential to gain high birefringence and gold is coated inside the elliptical air holes to generate surface Plasmon’s. A full vectorially 2D FDTD method is applied to analyse the guiding properties of proposed elliptical PCF depending on SPR. By improving the elliptical air hole of different parameter in cladding region, achieve one state of polarisation to propagation through the filter while the other state being attenuated. Beside this, we investigated the confinement loss of x polarised mode of 0.0218 dB/cm and corresponding y polarisation mode of 440.2dB/cm at an operating wavelength of 1.55µm. In addition an extinction ratio of proposed PCF of 330 dB/cm is determined while choosing the proposed PCF filter length being 1mm. The above proposed PCF length is set to 50µm and bandwidth being 300nm which is better than the previous reported literature. Based on above mentioned characteristics; the proposed PCF polarisation filter can be applied in compact and broadband filters in communication arena.
A global perspective and Indian schema of the current spatiotemporal variations and trends in ambient fine particulate pollutants (PM 2.5) concentration
Authors: Gupta Nishant , Agarwal Ashok Kumar , Amari Abdelfattah , Singhal Rajeev , Osman Haitham , Jindal Sanjay Kumar , Ghosh Tathagata , Yadav Virendra Kumar , Kumar Pankaj , Patel Ashish
Published: August 2023

PM2.5 concentration in India is severely high in many cities, especially in the Indo-Gangetic plains. During and after the COVID-19 pandemic, the regional air quality monitoring system has been improved under the new National Clean Air Program (NCAP) but the most concerned pollutant in the country is related to PM2.5. The available data are insufficient to evaluate the stable and post-pandemic air quality condition of India and its improvement The present study comprised data on the PM2.5 average of the last four years (2019 to 2022) from the most selected air monitoring stations of Indian states. Central Pollution Control Board (CPCB), National Air Quality Index (NAQI), Portal for Regulation of Air-pollution in non-Attainment Cities (PRANA), and international air quality databases such as NASA’s GIOVANNI and WHO’s ambient air pollution databases were incorporated to evaluate India’s current worldwide condition and potential reduction in PM2.5 concentration. Yearly athematic averages of the collected data were used to interpret the outcomes. The results suggested that the average concentration of PM2.5 of selected air monitoring stations in the last four years was 91.9 µg/m3 in 2019, 67.15 µg/m3 in 2020, 80.05 µg/m3 in 2021, and 92.65 µg/m3 in 2022. National Capital Delhi showed the highest PM2.5 level followed by North Indian States like Punjab and Rajasthan.
Design and analysis of a lower limb exoskeleton rehabilitation robot based on a series elastic actuator
Authors: ZHAO CHENGLONG , LIU ZHEN , ZHU LIUCUN
Published: August 2023

The aging population is a necessary trend in today's society, and there are increasing applications in everyday services through human-computer interaction, paramedicine and robotics. Lower limb exoskeleton rehabilitation robots have broad application prospects in the fields of enhancing human functions, rehabilitation training, and helping the elderly and disabled. In this paper, we combine the structural characteristics, motion mechanism, and gait characteristics of human lower limbs, bionic design of the exoskeleton mechanical structure, and propose a tandem elastic actuator with passive flexibility, low impedance, and force-controllable characteristics for application with robot joints. The kinematic analysis was carried out by the D-H parameter method, and the kinematic simulation was carried out by Matlab Robotic Toolbox software with the derived D-H parameters, and the fabrication and testing of the solid prototype were completed. The structural design and gait parameters were verified to be reasonable.
Agency of the local community in surface records of a nineteenth-century archaeological site in a rural area of Buenos Aires, Argentine Republic.
Authors: López Mariel Alejandra , Vommaro Miriam Noemí , Lanza María Alejandra
Published: August 2023

This paper presents the methods and techniques used to survey and analyse an archaeological site in the rural area of Buenos Aires Province with a high density of surface waste, and the results obtained relating to its formation and resettlement process between the nineteenth and twenty-first centuries.
The construction that remains standing to date is a typical nineteenth century dwelling. It is situated within what used to be the Old Town of San Vicente, next to the lagoon with the same name, in Buenos Aires Province, Argentine Republic.
The site, identified as San Vicente 3 (SV3), features material surface records that are the product of a true palimpsest: a mixture of archaeological events and old waste from the historical cemetery located in front of the site, and different types of objects and residues resulting from activities carried out by the neighbours that re-occupied the dwelling and moved around its surrounding area throughout the period referred to.
We proposed several tools for studying the site to record the high density and variety of materials and temporalities visible on the surface and determine the presence of different events in its formation.
Sparse Representation Based on Fourier Dictionary
Authors: Xu Huajun , Liu Ziping , Wang Guocheng
Published: August 2023

The purpose of studying the sparse representation of signals is to find the optimal approximation of the atoms of the signal under an over-complete dictionary, in which the characteristics of the atoms that match the signal are the characteristics of the signal. At present, the commonly used dictionaries in research include Fourier dictionary, cosine packet dictionary, wavelet packet dictionary, Chirplet dictionary, etc. However, there is little research on Fourier dictionaries from the point of Fourier transform theory. This paper studies three typical algorithms of sparse representation under Fourier dictionary (matching pursuit algorithm, basis pursuit algorithm and the method of frames), and the simulation results show that: 1) the matching pursuit algorithm can adaptively determine the time-frequency parameters of the signal. 2) The basis pursuit algorithm can enhance the ability to identify coupled harmonics, and the precision of reconstructed harmonics can reach 97%. 3) Implementation effect of the method of frames is consistent with fast discrete Fourier transform.
Quadratic and Lagrange interpolation based butterfly optimization algorithm by for numerical optimization and engineering design problem
Authors: Sharma Sushmita , Saha Apu Kumar , Chakraborty Sanjoy , Deb Suman , Sahoo Saroj Kumar
Published: August 2023

The Butterfly Optimization Algorithm (BOA) is used widely in the field of optimization due to its proven effectiveness. However, the algorithm has certain limitations such as poor exploration-exploitation balance, lack of diversity, and entrapment into local solutions. To overcome these limitations, a new and improved modification of BOA, called LQBOA, is projected, which employs the Lagrange interpolation formula and simple quadratic interpolation technique to improve the searching strategy and achieve a enhanced equilibrium between diversification and intensification. One of the parameter of BOA, switch probability has also been adaptively adjusted within a specified range, which enables initial exploration of the domain and later exploitation to obtain the global optima. The performance of LQBOA has been evaluated on forty-five classical benchmark problems and IEEE CEC 2017 benchmark suite. The simulation results have judged against that of several state-of-the-art algorithms, and statistical tests such as the Friedman rank test and Wilcoxon rank test have been conducted to justify the rank and significance of the proposed LQBOA. Additionally, convergence and diversity analysis have been carried out to study its searching behaviour.Furthermore, LQBOA has successfully applied to solve eight real-world engineering design problems. The results have been compared with various state-of-the-art algorithms, which demonstrate superior performance of LQBOA with improved exploration-exploitation balance, diversity, and avoidance of local optima. In conclusion, LQBOA represents a significant contribution to the optimization field, and its use could significantly improve the performance of various optimization tasks.
Finnish SQuAD: A Simple Approach to Machine Translation of Span Annotations
Authors: Nuutinen Emil , Rastas Iiro , Ginter Filip
Published: August 2023

We apply a simple method to machine translate datasets with span-level annotation using the DeepL MT service and its ability to translate formatted documents. Using this method, we produce a Finnish version of the SQuAD2.0 question answering dataset and train QA retriever models on this new dataset. We evaluate the quality of the dataset and more generally the MT method through direct evaluation, indirect comparison to other similar datasets, a backtranslation experiment, as well as through the performance of downstream trained QA models. In all these evaluations, we find that the method of transfer is not only simple to use but produces consistently better translated data. Given its good performance on the SQuAD dataset, it is likely the method can be used to translate other similar span-annotated datasets for other tasks and languages as well. All code and data is available under an open license: data at HuggingFace TurkuNLP/squad\_v2\_fi, code on GitHub TurkuNLP/squad2-fi, and model at HuggingFace TurkuNLP/bert-base-finnish-cased-squad2.
Effect of Delayed Scanning and Scanning Resolution Using Photostimulable Phosphor Plates On Detection of Vertical Root Fracture
Authors: Professor Elifhan ALAGOZ DMD Assistant , Professor Tugba PhD Assistant , Professor Aysegul YABACI PhD Assistant , Professor Serife OZD PhD Associate
Published: August 2023

Objectives
Detecting vertical root fractures(VRFs) can be challenging in dentistry due to their subtle and often concealed nature.This study aimed to assess the impact of varying resolutions and delayed scanning times of PSP plates on the diagnosis of VRFs. Can different resolutions and/or delayed scan times enhance the diagnosis of VRFs?
Materials and Methods
Forty extracted single-rooted premolar teeth were utilized. The crowns of all teeth were removed, and root canals were prepared.The teeth were divided into two groups:20 study teeth with VRFs and 20 teeth without VRFs. VRFs were created using an Instron machine. All tooth roots were positioned in the premolar region of a dry human mandible. Subsequently, periapical radiographs were taken using a parallel technique. Radiographs were scanned at four different times post-exposure:immediately, 30 minutes later, 2 hours later, and 4 hours later, and at three different resolutions:high speed, high resolution, and super high resolution.Statistical analyses were conducted using IBM SPSS Statistics 26.0.
Results
Intra- and interobserver agreement exhibited substantial to almost perfect ranges of agreement. Statistically significant differences were not observed in the diagnosis of VRFs when comparing different resolutions and scanning times.
Conclusions
Varying resolutions and/or delayed scan times did not improve the diagnosis of VRFs. In clinical practice, a comprehensive detection of VRFs might necessitate a combination of different imaging techniques, incorporation of artificial intelligence technology, and clinical assessment.
Clinical Relevance:
Engaging with an oral and maxillofacial radiologist or endodontist and taking into consideration their expertise and clinical judgment can prove to be advantageous for achieving precise diagnosis and effective treatment planning.
Does the Mindful Mind Wander? The Underlying Role of Self-compassion and Grit
Authors: Cheung Rebecca Y. M. , Djekou Lemuela
Published: August 2023

Previous research suggests that mindfulness and mind wandering are opposing constructs. However, little is known about why and how they are negatively related. Through a process-oriented approach, this study tested self-compassion and grit as mediators for the relation between mindfulness and mind wandering. A total of 487 meditators were recruited from the UK (241 female, 49.49%). Participants reported a mean age of 38.98 years (SD = 10.03), with an average of 2.26 hours of meditation practice per week (SD = 4.47). Upon informed consent, the participants completed a self-report questionnaire that assessed the core variables under study. A path model was conducted to investigate the mediation model. The path model revealed that mindfulness was related to self-compassion. Greater self-compassion was, in turn, related to greater grit, which was then related to lower mind wandering. Bootstrapping analysis further indicated that self-compassion and grit were mediators between mindfulness and mind wandering, above and beyond age, gender, and hours of meditation as covariates. This study revealed self-compassion and grit as mediators for the relation between mindfulness and mind wandering. These findings provided new evidence by showing the initial mechanisms between mindfulness and mind wandering.
Research on Turbine Speed Control Method Based on Flow Characteristics of Governing Valve
Authors: Wang Jiasheng , Ding Mingliang , Wang Suobing , Xie Deyong , Xiang Shang
Published: August 2023

Studies show that there are inherent lower rotor time constants at high-parameter and large-capacity thermal power units, which leads to poor rotational speed stability under traditional control methods in complicated power grid structures and operating conditions. Moreover, it is prone to induce various safety accidents. Based on the current development trend of steam turbines in China, this paper analyzes the theories of rotational speed instability under special conditions as the incompatibility between the unit’s inherent characteristics and the commonly used control idea. In this regard, a series of speed control ideas are proposed based on the flow characteristic of governing valve. Through analysis and comparison of several typical operating conditions and events, theoretical modeling, practical tests, and simulation identification, the theoretical analysis was verified. Flow characteristic curves of the governing valve and optimized strategies such as targeted control strategies and optimized operating procedures were adopted, and promising results were achieved in terms of safety and economy.
Comparison of Surgical Site Infections, Operative Outcomes and Scar Assessment in Gunsight Closure Technique versus Linear Closure for Stoma Reversal- A Randomized Clinical Trial
Authors: Tandup Cherring , Thakur Vipul , Sahu Swapnesh , Mehta Jay , Kaman Lileswar , Dahiya Divya , Jayant Divij , Khare Siddhant , Sakaray Yashwanth Raj , Thakur Manish , Satish S. N. , Babu Basil , Goyal Mrinal
Published: August 2023

Purpose
Stoma closure is associated with an increased risk of surgical site infection (SSI) and poor cosmetic scar. The incidence of SSI depends on the skin closure technique, the ideal stoma-site skin closure technique is still debated. The aim of this study was to compare the rate of SSI and scar assessment following the gunsight closure technique (GCT) and the linear closure technique (LC).
Methods
In this randomized clinical trial, 75 patients were enrolled who underwent stoma closure between November 2021 and April 2023. Patients were divided into two groups according to the skin closure technique, GCT (n = 41) and LC (n = 34). The incidence of SSI, readmission rates, length of hospital stays, and patients' scar satisfaction scores were compared.
Results
The two groups were similar in baseline and intra-operative characteristics, six (14.6%) patients in GCT group and 10 (29.4%) in the LC group developed SSI, and the difference was not significant. The length of hospital stay was significantly shorter in the GCT group (6.29 ± 2.43). Four patients were readmitted for SSI in LC group and none in the GCT group (p = 0.038). Patients in the GCT group were more satisfied with the scar at one month intervals based on the patient and observer scar assessment scale (POSAS).
Conclusion
GCT was associated with a lower incidence of SSI, a significant decrease in length of hospital stay, and a lower 90 days readmission rate for SSI as compared to LC. The cosmetic outcome was significantly more acceptable after GCT.