bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Single-Pulse Laser Welding of Dissimilar Metal Combination of Thin SUS303 SS and Cu
Authors: Huang Ruining , Huang Xuehao , Feng Junqiang
Published: September 2023

The present study investigated the dissimilar metal combination of SUS303 stainless steel (SS) and pure copper C19210 by utilizing a fiber pulse laser to perform lap welding. The weld quality was evaluated through metallurgical and mechanical examinations, including scanning electron microscopy (SEM), optical microscopy (OM), energy dispersive spectroscopy (EDS), as well as tensile and shear tests. The cross-section of the weld joints was observed to examine the penetration inside the molten zone of the pulse laser welding. The incomplete weld penetration depth was confirmed by analyzing the molten pool geometry, which indicated that the penetration depth was proportional to the pulse heat energy input. EDS analysis demonstrated that interdiffusion and dissolution of Cu and SS occurred inside the weld pool, although only a limited amount of Cu was melted. Microhardness (MH) exploration revealed the hardness of the molten zone was lower than that of the heat-affected zone (HAZ) on the SS side, while the hardness on the Cu side, closer to the molten zone, was higher. The results of the tensile test indicated that the fracture occurred in the HAZ on the Cu side, displaying a dimpled fracture mode characteristic of ductile fracture.
Multivariate Time-Series Classification of Critical Events from Industrial Drying Hopper Operations: A Deep Learning Approach
Authors: Rahman Md Mushfiqur , Farahani Mojtaba Askarzadeh , Wuest Thorsten
Published: September 2023

In recent years, the advancement of Industry 4.0 and smart manufacturing has made a large amount of industrial process data attainable with the use of sensors installed on machines. This paper proposes an experimental predictive maintenance framework for an industrial drying hopper so that it can detect any unusual event in the hopper, which reduces the risk of erroneous fault diagnosis in the manufacturing shop floor. The experimental framework uses Deep Learning (DL) algorithms to classify Multivariate Time-Series (MTS) data into two categories—failure or unusual events and regular events—thus formulating the problem as a binary classification. The raw data extracted from the sensors contained missing values, suffered from imbalancedness, and were not labeled. Therefore, necessary preprocessing is performed to make them usable for DL algorithms and the dataset is self-labeled after defining the two categories precisely. To tackle the imbalanced data issue, data balancing techniques like ensemble learning with undersampling and Synthetic Minority Oversampling Technique (SMOTE) are used. Moreover, along with DL algorithms like Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM), Machine Learning (ML) algorithms like Support Vector Machine (SVM) and K-nearest neighbor (KNN) have also been used to perform a comparative analysis on the results obtained from these algorithms. The result shows that CNN is arguably the best algorithm for classifying this dataset into two categories and outperforms other traditional approaches as well as deep learning algorithms.
Improved Low-Drag Pontoons for Water Bikes
Authors: Nesteruk Igor , Krile Srećko , Möller Thorsten
Published: September 2023

The popularity of modern water bikes increases due to the relatively high speed developed with the use of a human muscle power only. For example, the maximum speed of prototypes reaches the value 3 m/s. Similar vehicles can be used not only for recreation and fitness, but also for transportation. To increase their speed and tonnage, we recommend improving the pontoon shape and using electrical power. The underwater part of the pontoon shape was recommended to be similar to the body shape of the fastest fish in order to decrease the wave resistance and total drag. The optimal depth of the movement of corresponding shapes was calculated. The total drag and maximum speeds of the vehicles with the human muscle and electrical power are estimated. Expected success in improving the pontoon shape opens wide prospects for the use of these special-shaped hulls in shipbuilding.
Attitude Estimation Method for Target Ships Based on LiDAR Point Clouds via An Improved RANSAC
Authors: Wei Shengzhe , Xiao Yuminghao , Yang Xinde , Wang Hongdong
Published: September 2023

The accurate attitude estimation of target ships plays a vital role in ensuring the safety of marine transportation, especially for tugs. A Light Detection and Ranging (LiDAR) system can generate 3D point clouds to describe the target ship’s geometric features that possess attitude information. In this work, the authors put forward a new attitude-estimation framework that first extracts the geometric features (i.e., the board-side plane of a ship) using point clouds from shipborne LiDAR and then computes the attitude that is of interest (i.e., yaw and roll in this paper). To extract the board-side plane accurately on a moving ship with sparse point clouds, an improved Random Sample Consensus (RANSAC) algorithm with a pre-processing normal vector-based filter was designed to exclude noise points. A real water-pool experiment and two numerical tests were carried out to demonstrate the accuracy and general applicability of the attitude estimation of target ships brought by the improved RANSAC and estimation framework. The experimental results show that the average mean absolute errors of the angle and angular-rate estimation are 0.4879 deg and 4.2197 deg/s, respectively, which are 92.93% and 75.36% more accurate than the estimation based on standard RANSAC.
Can BPA Analogs Affect Cellular and Biochemical Responses in the Microalga Phaeodactylum tricornutum Bohlin?
Authors: Fabrello Jacopo , Ciscato Maria , Moschin Emanuela , Vecchia Francesca Dalla , Moro Isabella , Matozzo Valerio
Published: September 2023

Bisphenol A analogs (BPA analogs) are emerging contaminants with a rising production caused by the replacement of BPA with these compounds. The increased production of BPA analogs is leading to their increased release into various ecosystems, including marine ones. The aim of this study was to evaluate the biological effects of BPA analogs on a primary producer, the diatom Phaeodactylum tricornutum Bohlin. Three different BPA analogs (BPAF, BPF, and BPS) and their mixture were tested at the environmental relevant concentration of 300 ng/L. Growth, cell size and several biomarkers of oxidative stress and oxidative damage were measured. Our results indicated that the tested compounds caused a reduced growth rate and induced oxidative stress, altering many antioxidant enzymes in P. tricornutum. However, no oxidative damages were observed.
Pain and Its Management in Patients Referred to a Geriatric Outpatient Clinic
Authors: Rutkowski Krzysztof , Wyszatycki Mateusz , Ejdys Krystian , Hawryluk Natalia Maria , Stompór Małgorzata
Published: September 2023

(1) Background: A major problem affecting geriatric patients is pain. In addition to pain, a significant problem of old age is dementia and depression, which can hinder the diagnosis and treatment of pain. The aim of this study was to analyse the prevalence of pain in patients treated in a geriatric outpatient clinic and the treatment used. (2) Methods: The analysis was based on the records of 937 patients who visited the Geriatric Outpatient Clinic in Dobre Miasto between 2015 and 2020. Based on records containing data dating back to their first visit to the hospital, patients’ experiences of pain, the presence of depressive symptoms and dementia, and the pharmacological treatment used for pain (analgesics and coanalgesics) were analysed. (3) Results: Pain complaints were reported by 311 patients (33.2% of the study group), 76% of the complaints were from females. The mean age of the patients was 78 years (SD = 8.45). At least one analgesic drug was taken by 107 patients (34.4%). The most commonly used analgesics were opioids (63 patients, 58.87%), especially tramadol. Of the potential coanalgesics, the largest number of patients used an antidepressant. (4) Conclusions: Despite the widespread prevalence of pain among the elderly, only about one-third of them were taking pain medication, mainly in the form of weak opioids. Patients with symptoms of dementia were found to report pain less frequently.
Evaluation of Urban Green Space Supply and Demand Based on Mobile Signal Data: Taking the Central Area of Shenyang City as an Example
Authors: Dong Yukuan , Chen Xi , Lv Dongyang , Wang Qiushi
Published: September 2023

The degree of coordination between the supply and demand for urban green spaces serves as a vital metric for evaluating urban ecological development and the well-being of residents. An essential principle in assessing this coordination is the precise quantification of both the demand and supply of green spaces, as well as the differential representation of their spatiotemporal structures. This study utilizes the entropy weight method (EWM) and principal component analysis (PCA) to comprehensively measure supply indicators for green space quantity and quality in the central urban area of Shenyang, China. To establish reliable and quantifiable demand indicators, mobile signaling spatial-temporal data are corrected by incorporating static population cross-sectional data. The Gaussian two-step floating catchment area method (Ga2SFCA) is employed to calculate the accessibility of green spaces in each community with ArcGIS 10.2 software, while the Gini coefficient is utilized to assess the equity of green space distribution within the study area. This study employs location entropy to determine the levels of supply and demand for green spaces in each subdistrict. Furthermore, the priority of community-scale green space regulation is accurately determined by balancing vulnerable areas of green space supply and replenishing green space resources for the ageing population. The findings suggest a Gini coefficient of 0.58 for the supply and demand of green spaces in Shenyang’s central metropolitan region, indicating a relatively low level of equalization in overall green space allocation. Based on location entropy, the classification of supply and demand at the street level yields the following outcomes: balanced areas comprise 21.98%, imbalanced areas account for 26.37%, and highly imbalanced regions represent 51.65%. After eliminating the balanced regions, the distribution of the elderly population is factored in, highlighting the spatial distribution and proportions of communities with distinct regulatory priorities: Level 1 (S1) constitutes 7.4%, Level 2 (S2) accounts for 60.9%, and Level 3 (S3) represents 31.7%. Notably, the communities in the S1 category exhibit spatial distribution characteristics of aggregation within the inner ring and the northern parts of the third ring. This precise identification of areas requiring urgent regulation and the spatial distribution of typical communities can provide reliable suggestions for prioritizing green space planning in an age-friendly city.
Optimizing Management of the Qinling–Daba Mountain Area Based on Multi-Scale Ecosystem Service Supply and Demand
Authors: Yu Yuyang , Wang Yunqiu , Li Jing , Han Liqin , Zhang Shijie
Published: September 2023

Accurately identifying the supply and demand of ecosystem services at multiple scales and determining the factors that influence the supply–demand relationship are crucial for guiding the sustainable management and restoration of regional ecosystem services. In view of this, we quantified the supply and demand of five ecosystem services at multiple scales in the Qinling–Daba Mountain area based on spatial and statistical data, exploring the relationships between the supply and demand for ecosystem services at multiple scales and examining the mechanisms by which factors like natural and human activities affect the evolution of the supply and demand patterns of these services. The results show that (1) there was no risk associated with supply and demand of ESs in the Qinling–Daba Mountain area, and numerous ESs were in excess. The impact of ES supply and demand became increasingly clear as the spatial scale was increased. (2) Under multiple spatial scales, the relationship between the supply and demand of ESs will change. At the mesoscale, the relationship between ES supply and demand was the most significant, whereas at the macroscale, the relationship between ES demands was the most significant. (3) Cultivated land, grass land, and forest land are the key land use categories in regional ecosystem service hotspots, providing richer ecosystem service functions for the region. (4) Precipitation and NDVI are the main elements determining the supply of ecosystem services. While GDP and population density have a significant impact on the demand for ecosystem services, natural causes are primarily responsible for trade-offs in ecosystem services. This study aims to evaluate the supply–demand relationship and driving factors of multiple scale in the Qinling–Daba Mountains, providing a scientific basis for the sustainable management of ecosystems in the region.
The Pragmatics and Argumentation Interface
Authors: Oswald Steve
Published: September 2023

It can be argued that linguistic aspects of argumentation have attracted scholarly attention ever since the foundation of rhetoric, which originally developed as the study of means of persuasion, and thus, to a fair extent, that linguistics plays an important role in the study of argumentation at large [...]
Design, Implementation, and Control of a Linear Electric Actuator for Educational Mechatronics
Authors: Nava-Pintor Jesús Antonio , Carlos-Mancilla Miriam A. , Guerrero-Osuna Héctor A. , Luque-Vega Luis F. , Carrasco-Navarro Rocío , Castro-Tapia Salvador , Mata-Romero Marcela E. , González-Jiménez Luis E. , Solís-Sánchez Luis Octavio
Published: September 2023

Kinematics is a fundamental topic in engineering, robotics, mechatronics, and control systems and significantly resolves some of these fields’ most pressing issues. It is essential to assess the balance between a topic’s theoretical framework and its empirical validation to succeed in engineering. Educational tools have gained significant attention for their ability to enhance the learning experience by providing the hands-on experiences necessary to assess theoretical frameworks and empirical validations. This paper presents a system incorporating state-of-the-art features, including a fuzzy controller enabling precise control of a linear actuator and a USB camera, to provide an interactive experience. The USB camera captures the position of the actuator, providing real-time visual feedback and allowing the students to validate their theoretical understanding through practical experiments. Precision, accuracy, resolution, and the implementation of the fuzzy controller are measured to evaluate the whole system’s performance. The design, implementation, and control of our educational electrical linear actuator for teaching kinematics concepts contribute to a practical educational tool and advance interactive learning approaches in the field.
3D-ShuffleViT: An Efficient Video Action Recognition Network with Deep Integration of Self-Attention and Convolution
Authors: Wang Yinghui , Zhu Anlei , Ma Haomiao , Ai Lingyu , Song Wei , Zhang Shaojie
Published: September 2023

Compared with traditional methods, the action recognition model based on 3D convolutional deep neural network captures spatio-temporal features more accurately, resulting in higher accuracy. However, the large number of parameters and computational requirements of 3D models make it difficult to deploy on mobile devices with limited computing power. In order to achieve an efficient video action recognition model, we have analyzed and compared classic lightweight network principles and proposed the 3D-ShuffleViT network. By deeply integrating the self-attention mechanism with convolution, we have introduced an efficient ACISA module that further enhances the performance of our proposed model. This has resulted in exceptional performance in both context-sensitive and context-independent action recognition, while reducing deployment costs. It is worth noting that our 3D-ShuffleViT network, with a computational cost of only 6% of that of SlowFast-ResNet101, achieved 98% of the latter’s Top1 accuracy on the EgoGesture dataset. Furthermore, on the same CPU (Intel i5-8300H), its speed was 2.5 times that of the latter. In addition, when we deployed our model on edge devices, our proposed network achieved the best balance between accuracy and speed among lightweight networks of the same order.
Circular Economy in Membrane Technology
Authors: Landaburu-Aguirre Junkal , Molina Serena
Published: September 2023

The European Union (EU) produces more than 2 [...]
Phase Field Simulations of Microstructures in Porous Ferromagnetic Shape Memory Alloy Ni2MnGa
Authors: Xu Cailian , Huang Yu , Liang Yongfeng , Wu Pingping
Published: September 2023

The magnetic domain structures and martensite microstructures of porous Ni2MnGa Heusler alloys with various circle-shaped and ellipse-shaped pores were systematically studied by the phase field method. The magnetization curves and magnetic field-induced strains (MFIS) at the external field were determined. A mesoscopic mechanism was proposed for simulation to reveal the influence of the pores on the microstructures and the MFIS of porous magnetic shape memory alloy. The stress concentration effect and the recovery strain of the porous alloy are studied. The results indicate the MFIS value increases when ellipse-shaped pores elongate along the twin boundary. The effects of porosity and pore size on MFIS for porous Ni-Mn-Ga alloys with randomly distributed pores were also explored. The present study is of guiding significance for understanding the role played by pores on the MFIS and may provide a possible way to adjust the functional properties of ferromagnetic shape memory alloys.
Chitinolytic and Fungicidal Potential of the Marine Bacterial Strains Habituating Pacific Ocean Regions
Authors: Pentekhina Iuliia , Nedashkovskaya Olga , Seitkalieva Aleksandra , Gorbach Vladimir , Slepchenko Lubov , Kirichuk Natalya , Podvolotskaya Anna , Son Oksana , Tekutyeva Liudmila , Balabanova Larissa
Published: September 2023

Screening for chitinolytic activity in the bacterial strains from different Pacific Ocean regions revealed that the highly active representatives belong to the genera Microbulbifer, Vibrio, Aquimarina, and Pseudoalteromonas. The widely distributed chitinolytic species was Microbulbifer isolated from the sea urchin Strongylocentrotus intermedius. Among seventeen isolates with confirmed chitinolytic activity, only the type strain P. flavipulchra KMM 3630T and the strains of putatively new species Pseudoalteromonas sp. B530 and Vibrio sp. Sgm 5, isolated from sea water (Vietnam mollusc farm) and the sea urchin S. intermedius (Peter the Great Gulf, the Sea of Japan), significantly suppressed the hyphal growth of Aspergillus niger that is perspective for the biocontrol agents’ development. The results on chitinolytic activities and whole-genome sequencing of the strains under study, including agarolytic type strain Z. galactanivorans DjiT, found the new functionally active chitinase structures and biotechnological potential.
Comparative Structure Analysis of the Multi-Domain, Cell Envelope Proteases of Lactic Acid Bacteria
Authors: Christensen Lise Friis , Høie Magnus Haraldson , Bang-Berthelsen Claus Heiner , Marcatili Paolo , Hansen Egon Bech
Published: September 2023

Lactic acid bacteria (LAB) have an extracellular proteolytic system that includes a multi-domain, cell envelope protease (CEP) with a subtilisin homologous protease domain. These CEPs have different proteolytic activities despite having similar protein sequences. Structural characterization has previously been limited to CEP homologs of dairy- and human-derived LAB strains, excluding CEPs of plant-derived LAB strains. CEP structures are a challenge to determine experimentally due to their large size and attachment to the cell envelope. This study aims to clarify the prevalence and structural diversity of CEPs by using the structure prediction software AlphaFold 2. Domain boundaries are clarified based on a comparative analysis of 21 three-dimensional structures, revealing novel domain architectures of CEP homologs that are not necessarily restricted to specific LAB species or ecological niches. The C-terminal flanking region of the protease domain is divided into fibronectin type-III-like domains with various structural traits. The analysis also emphasizes the existence of two distinct domains for cell envelope attachment that are preceded by an intrinsically disordered cell wall spanning domain. The domain variants and their combinations provide CEPs with different stability, proteolytic activity, and potentially adhesive properties, making CEPs targets for steering proteolytic activity with relevance for both food development and human health.
Growing in Saltwater: Biotechnological Potential of Novel Methylotuvimicrobium- and Methylomarinum-like Methanotrophic Bacteria
Authors: Tikhonova Ekaterina N. , Suleimanov Ruslan Z. , Oshkin Igor Y. , Konopkin Aleksey A. , Fedoruk Diana V. , Pimenov Nikolai V. , Dedysh Svetlana N.
Published: September 2023

Methanotrophic bacteria that possess a unique ability of using methane as a sole source of carbon and energy have attracted considerable attention as potential producers of a single-cell protein. So far, this biotechnology implied using freshwater methanotrophs, although many regions of the world have limited freshwater resources. This study aimed at searching for novel methanotrophs capable of fast growth in saltwater comparable in composition with seawater. A methane-oxidizing microbial consortium containing Methylomarinum- and Methylotuvimicrobium-like methanotrophs was enriched from sediment from the river Chernavka (water pH 7.5, total salt content 30 g L−1), a tributary river of the hypersaline Lake Elton, southern Russia. This microbial consortium, designated Ch1, demonstrated stable growth on natural gas in a bioreactor in media with a total salt content of 23 to 35.9 g L−1 at a dilution rate of 0.19–0.21 h−1. The highest biomass yield of 5.8 g cell dry weight (CDW)/L with a protein content of 63% was obtained during continuous cultivation of the consortium Ch1 in a medium with a total salt content of 29 g L−1. Isolation attempts resulted in obtaining a pure culture of methanotrophic bacteria, strain Ch1-1. The 16S rRNA gene sequence of strain Ch1-1 displayed 97.09–97.24% similarity to the corresponding gene fragments of characterized representatives of Methylomarinum vadi, methanotrophs isolated from marine habitats. The genome of strain Ch1-1 was 4.8 Mb in size and encoded 3 rRNA operons, and about 4400 proteins. The genome contained the gene cluster coding for ectoine biosynthesis, which explains the ability of strain Ch1-1 to tolerate high salt concentration.
Source Rock Evaluation from Rock to Seismic Data: An Integrated Machine-Learning-Based Work Flow and Application in the Brazilian Presalt (Santos Basin)
Authors: Reis Maria Anna Abreu de Almeida dos , Damasceno Andrea Carvalho , Roriz Carlos Eduardo Dias , Korenchendler André Leonardo , Silva Atilas Meneses da , Praxedes Eric da Silva , Silva Vitor Gorni
Published: September 2023

The capacity to predict the occurrence and quality of source rocks in a sedimentary basin is of great economic importance in the evaluation of conventional and non-conventional petroleum resources. Direct laboratory examinations of rock samples are the most accurate way to obtain their geochemical properties. However, rock information is usually sparse, and source rocks are often sampled at positions that may not be representative of the average organic content and quality of oil kitchens. This work proposes a work flow supported by machine learning methods (random forest, DBSCAN, and NGBoost) to automate the source rock characterization process to maximize the use of available data, expand data information, and reduce data analysis time. From the automated quality control of the input data through the extrapolation of laboratory measurements to continuous well logs of geochemical properties, culminating in the 3D estimation of these properties, we generate volumes of total organic carbon (TOC) by applying machine learning techniques. The proposed method provides more accurate predictions, reducing uncertainties in the characterization of source rocks and assisting in exploratory decision making. This methodology was applied in the presalt source rocks from Santos Basin (Brazil) and allowed us to quantify the TOC distribution, improving the interpretation of the main source rock interval top and base based only on seismic amplitude data. The result suggests higher TOC values in the northern and western grabens of the studied area and a higher charge risk in the eastern area.
Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey
Authors: Shahid Hamna , Shah Aqeel Ahmed , Shah Bukhari Syed Nizam Uddin , Naqvi Anjum Zehra , Arooj Iqra , Javeed Mehvish , Aslam Muhammad , Chandio Ali Dad , Farooq Muhammad , Gilani Sadaf Jamal , Bin Jumah May Nasser
Published: September 2023

Green approaches for nanoparticle synthesis have emerged as biocompatible, economical, and environment-friendly alternatives to counteract the menace of microbial drug resistance. Recently, the utilization of honey as a green source to synthesize Fe2O3-NPs has been introduced, but its antibacterial activity against one of the opportunistic MDR pathogens, Klebsiella pneumoniae, has not been explored. Therefore, this study employed Apis mellifera honey as a reducing and capping agent for the synthesis of iron oxide nanoparticles (Fe2O3-NPs). Subsequent to the characterization of nanoparticles, their antibacterial, antioxidant, and anti-inflammatory properties were appraised. In UV-Vis spectroscopic analysis, the absorption band ascribed to the SPR peak was observed at 350 nm. XRD analysis confirmed the crystalline nature of Fe2O3-NPs, and the crystal size was deduced to be 36.2 nm. Elemental analysis by EDX validated the presence of iron coupled with oxygen in the nanoparticle composition. In ICP-MS, the highest concentration was of iron (87.15 ppm), followed by sodium (1.49 ppm) and other trace elements (<1 ppm). VSM analysis revealed weak magnetic properties of Fe2O3-NPs. Morphological properties of Fe2O3-NPs revealed by SEM demonstrated that their average size range was 100–150 nm with a non-uniform spherical shape. The antibacterial activity of Fe2O3-NPs was ascertained against 30 clinical isolates of Klebsiella pneumoniae, with the largest inhibition zone recorded being 10 mm. The MIC value for Fe2O3-NPs was 30 µg/mL. However, when mingled with three selected antibiotics, Fe2O3-NPs did not affect any antibacterial activity. Momentous antioxidant (IC50 = 22 µg/mL) and anti-inflammatory (IC50 = 70 µg/mL) activities of Fe2O3-NPs were discerned in comparison with the standard at various concentrations. Consequently, honey-mediated Fe2O3-NP synthesis may serve as a substitute for orthodox antimicrobial drugs and may be explored for prospective biomedical applications.
Structures, Antioxidant Properties, and Antimicrobial Properties of Eu(III), Gd(III), and Dy(III) Caffeinates and p-Coumarates
Authors: Świderski Grzegorz , Kalinowska Monika , Gołębiewska Ewelina , Świsłocka Renata , Lewandowski Włodzimierz , Kowalczyk Natalia , Naumowicz Monika , Cudowski Adam , Pietryczuk Anna , Nalewajko-Sieliwoniuk Edyta , Wysocka Izabela , Arciszewska Żaneta , Godlewska-Żyłkiewicz Beata
Published: September 2023

In this study, we investigated the structures of lanthanide (Eu(III), Dy(III), and Gd(III)) complexes with p-coumaric (p-CAH2) and caffeic (CFAH3) acids using the FTIRKBr, FTIRATR, and Raman spectroscopic methods. The compositions of the solid phase caffeinates and p-coumarates were obtained on the basis of the amounts of hydrogen and carbon determined using an elemental analysis. The degree of hydration and the thermal decomposition of each compound were examined via a thermal analysis of TG, DTG, and DSC. Antioxidant spectroscopic tests were performed using the DPPH (1,1-diphenyl-2-picrylhydrazyl radical), FRAP (ferric reducing antioxidant activity), and ABTS (2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (diammonium salt radical cation) methods. The antimicrobial activity of each compound against Escherichia coli, Bacillus subtilis, and Candida albicans was investigated. The electrical properties of the liposomes which mimicked the microbial surfaces formed in the electrolyte containing the tested compounds were also investigated. The above biological properties of the obtained complexes were compared with the activities of p-CAH2 and CFAH3. The obtained data suggest that lanthanide complexes are much more thermally stable and have higher antimicrobial and antioxidant properties than the ligands (with the exception of CFAH3 in the case of antioxidant activity tests). The Gd(III) complexes revealed the highest biological activity among the studied lanthanide complexes.
Quantification of Metal(loid)s in Lubricating Eye Drops Used in the Treatment of Dry Eye Disease
Authors: Oliveira Marcelo de , Melo Elaine S. de Pádua , Silva Thaís Carvalho da , Cardozo Carla Maiara Lopes , Siqueira Igor Valadares , Hamaji Mariana Pereira , Braga Vanessa Torres , Martin Luiz Fernando Taranta , Fonseca Alessandro , Nascimento Valter Aragão do
Published: September 2023

The aim of the study was to evaluate the presence of metal(loid)s in lubricating eye drops used in the treatment of dry eye disease. The concentrations of Al, As, Ba, Cd, Co, Cu, Cr, Pb, Fe, Mg, Mn, Mo, Ni, Se, V, and Zn were determined in 19 eye drop samples using inductively coupled plasma optical emission spectrometry (ICP OES). The limit of detection (LOD) and limit of quantification (LOQ) values for the quantified elements ranged from 0.0002–0.0363 (mg/L) and 0.0007–0.1211 (mg/L), respectively. High values of concentrations of Al (2.382 µg/g), As (0.204 µg/g), Ba (0.056 µg/g), Cd (0.051 µg/g), Co (1.085 µg/g), Cr (0.020 µg/g), Cu (0.023 µg/g), Fe (0.453 µg/g), Mg (24.284 µg/g), Mn (0.014 µg/g), Mo (0.046 µg/g), Ni (0.071 µg/g), Pb (0.049 µg/g), Se (0.365 µg/g), V (0.083 µg/g), and Zn (0.552 µg/g) were quantified in samples of eye drops with and without preservatives. The concentrations of As (5 samples) and Cd (3 samples) were higher than those allowed by the Brazilian Pharmacopoeia for impurities (parenteral use). The value of Co content (µg/g) in a sample was higher than the value established by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH Q3D (R2)) in the parenteral route. The daily eye drop instillation exposure (µg/day) was below the values from the parenteral-permitted daily exposure (PDE) set by the ICH Q3D guideline (R2). The presence of heavy metals in eye drops is an alert to regulatory agencies in several countries so that control and inspections can be carried out.
Anisotropic Mechanical Properties of Orthorhombic SiP2 Monolayer: A First-Principles Study
Authors: Hou Yinlong , Ren Kai , Wei Yu , Yang Dan , Cui Zhen , Wang Ke
Published: September 2023

In recent years, the two-dimensional (2D) orthorhombic SiP2 flake has been peeled off successfully by micromechanical exfoliation and it exhibits an excellent performance in photodetection. In this paper, we investigated the mechanical properties and the origin of its anisotropy in an orthorhombic SiP2 monolayer through first-principles calculations, which can provide a theoretical basis for utilizing and tailoring the physical properties of a 2D orthorhombic SiP2 in the future. We found that the Young’s modulus is up to 113.36 N/m along the a direction, while the smallest value is only 17.46 N/m in the b direction. The in-plane anisotropic ratio is calculated as 6.49, while a similar anisotropic ratio (~6.55) can also be observed in Poisson’s ratio. Meanwhile, the in-plane anisotropic ratio for the fracture stress of the orthorhombic SiP2 monolayer is up to 9.2. These in-plane anisotropic ratios are much larger than in black phosphorus, ReS2, and biphenylene. To explain the origin of strong in-plane anisotropy, the interatomic force constants were obtained using the finite-displacement method. It was found that the maximum of interatomic force constant along the a direction is 5.79 times of that in the b direction, which should be considered as the main origin of the in-plane anisotropy in the orthorhombic SiP2 monolayer. In addition, we also found some negative Poisson’s ratios in certain specific orientations, allowing the orthorhombic SiP2 monolayer to be applied in next-generation nanomechanics and nanoelectronics.
Investigating the Effect of Operational Variables on the Yield, Characterization, and Properties of End-of-Life Olive Stone Biomass Pyrolysis Products
Authors: Atakoohi Sina Ebrahim , Spennati Elena , Casazza Alessandro A. , Riani Paola , Garbarino Gabriella
Published: September 2023

In recent years, biomass has emerged as a promising raw material to produce various products, including hydrocarbons, platform chemicals, and fuels. However, a more comprehensive evaluation of the potential production of desirable value-added products and chemical intermediates is required. For these reasons, this study aimed to investigate the impact of various operating parameters on the pyrolysis of end-of-life olive stone, an agriculture and food industry waste, using a tubular quartz reactor operated at 773 K. The results revealed that the product compositions were comparable under batch or semi-batch nitrogen feeding conditions and with reaction times of 1 or 3 h. The product distribution and composition were significantly influenced by changes in the heating rate from 5 to 50 K min−1, while the effect of changing the biomass particle size from 0.3 to 5 mm was negligible in the semi-batch test. This work provides a comprehensive understanding of the relationship between pyrolysis operational parameters and obtained product distribution and composition. Moreover, the results confirmed the possible exploitation of end-of-life olive stone waste to produce high-added value compounds in the zero-waste strategy and biorefinery concept.
Active Surveillance of Antimicrobial Resistance and Carbapenemase-Encoding Genes According to Sites of Care and Age Groups in Mexico: Results from the INVIFAR Network
Authors: Rojas-Larios Fabian , Martínez-Guerra Bernardo Alfonso , López-Jácome Luis Esaú , Bolado-Martínez Enrique , Vázquez-Larios María del Rosario , Velázquez-Acosta María del Consuelo , Romero-Romero Daniel , Mireles-Dávalos Christian Daniel , Quintana-Ponce Sandra , Feliciano-Guzmán José Manuel , Pérez-Hernandez José Miguel , Correa-León Yoselin Paola , López-Gutiérrez Eduardo , Rodriguez-Noriega Eduardo , González-Díaz Esteban , Choy-Chang Elena Victoria , Mena-Ramírez Juan Pablo , Monroy-Colín Víctor Antonio , Ponce-de-León-Garduño Alfredo , Alcaraz-Espejel Margarita , Avilés-Benítez Laura Karina , Quintanilla-Cazares Luís Javier , Ramírez-Alanís Eloisa , Barajas-Magallón Juan Manuel , Padilla-Ibarra Cecilia , Ballesteros-Silva Maria Bertha , Atanacio-Sixto Noe Antonio , Morales-de-la-Peña Cecilia Teresita , Galindo-Méndez Mario , Pérez-Vicelis Talía , Jacobo-Baca Guillermo , Moreno-Méndez Martha Irene , Mora-Pacheco María de la Luz , Gutiérrez-Brito Maricruz , Sánchez-Godínez Xochitl Yadira , Navarro-Vargas Norberta Vianey , Mercado-Bravo Luz Elena , Delgado-Barrientos Alejandro , Santiago-Calderón María Asunción , López-Ovilla Ismelda , Molina-Chavarria Alejandro , Rincón-Zuno Joaquín , Franco-Cendejas Rafael , Miranda-Mauricio Sandra , Márquez-Avalos Isabel Cristina , López-García Maribel , Duarte-Miranda Lizbeth Soraya , Cetina-Umaña Carlos Miguel , Barroso-Herrera-y-Cairo Irma Elena , López-Moreno Laura Isabel , Garza-González Elvira
Published: September 2023

We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates of Escherichia coli (n = 3985), Klebsiella pneumoniae (n = 775), Acinetobacter baumannii (n = 163), Pseudomonas aeruginosa (n = 781), Enterococcus faecium (n = 124), and Staphylococcus aureus (n = 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) and the disk diffusion susceptibility method (6/43). The presence of carbapenemase-encoding genes was assessed using PCR. Data from centers regarding site of care, patient age, and clinical specimen were collected. According to the site of care, the highest AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from ICU patients. In contrast, in A. baumannii, higher AMR was observed in isolates from hospitalized non-ICU patients. According to age group, the highest AMR was observed in the ≥60 years age group for E. coli, E. faecium, and S. aureus, and in the 19–59 years age group for A. baumannii and P. aeruginosa. According to clinical specimen type, a higher AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from blood specimens. The most frequently detected carbapenemase-encoding gene in E. coli was blaNDM (84%).
Host and HBV Interactions and Their Potential Impact on Clinical Outcomes
Authors: Jose-Abrego Alexis , Roman Sonia , Laguna-Meraz Saul , Panduro Arturo
Published: September 2023

Hepatitis B virus (HBV) is a challenge for global health services, affecting millions and leading thousands to end-stage liver disease each year. This comprehensive review explores the interactions between HBV and the host, examining their impact on clinical outcomes. HBV infection encompasses a spectrum of severity, ranging from acute hepatitis B to chronic hepatitis B, which can potentially progress to cirrhosis and hepatocellular carcinoma (HCC). Occult hepatitis B infection (OBI), characterized by low HBV DNA levels in hepatitis B surface antigen-negative individuals, can reactivate and cause acute hepatitis B. HBV genotyping has revealed unique geographical patterns and relationships with clinical outcomes. Moreover, single nucleotide polymorphisms (SNPs) within the human host genome have been linked to several clinical outcomes, including cirrhosis, HCC, OBI, hepatitis B reactivation, and spontaneous clearance. The immune response plays a key role in controlling HBV infection by eliminating infected cells and neutralizing HBV in the bloodstream. Furthermore, HBV can modulate host metabolic pathways involved in glucose and lipid metabolism and bile acid absorption, influencing disease progression. HBV clinical outcomes correlate with three levels of viral adaptation. In conclusion, the clinical outcomes of HBV infection could result from complex immune and metabolic interactions between the host and HBV. These outcomes can vary among populations and are influenced by HBV genotypes, host genetics, environmental factors, and lifestyle. Understanding the degrees of HBV adaptation is essential for developing region-specific control and prevention measures.
Study and Characterization of H3PO4 Activated Carbons Prepared from Jujube Stones for the Treatment of Industrial Textile Effluents
Authors: Bouchelkia Nasma , Benazouz Kheira , Mameri Amal , Belkhiri Lazhar , Hamri Nadia , Belkacemi Hayet , Zoukel Abdelhalim , Amrane Abdeltif , Aoulmi Fodil , Mouni Lotfi
Published: September 2023

Dyes are responsible for major environmental issues globally due to their toxicity, large-scale production, and extensive use in various industrial sectors. Pollution caused by hazardous dyes is mainly due to textile waste, which is constantly discharged into the aquatic system, often causing harm to humans and affecting water quality. In recent years, the removal of dyes from industrial textile wastewater has been a major challenge. Numerous technologies and methods have been developed to remove dyes from wastewater and meet clean water requirements. In this study, the effectiveness of activated carbon prepared by chemical activation of jujube stones for textile wastewater treatment was investigated. The effects of the concentration of H3PO4 and the carbonization temperature on the activated carbon’s properties were studied. Several physicochemical methods, including Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction, methylene blue index, Boehm titration, iodine index and pH point of zero charge, were considered to characterize the produced adsorbents. To assess the quality of the two studied textile effluents (Mustard and Violet), the following parameters were used: biological oxygen demand (BOD), chemical oxygen demand (COD), turbidity, suspended particles and dissolved solids, before and after treatment with the produced activated carbon. Untreated wastewater analysis revealed high values for almost all parameters: pH > 9, COD of 302.72 mg/L and 230.68 mg/L for Mustard and Violet effluent, respectively. Both effluents from an industrial textile factory exhibited a COD/BOD ratio higher than three, which restricts their biodegradability. Examination of the effect of contact time and activated carbon dosage on the treatment of the two effluents showed that 4 g/L of activated carbon and 60 min of contact time were sufficient for optimal treatment, resulting in pollutant removal rates of 81.03 and 84.65% for the Violet and Mustard effluents, respectively. The results of this research highlight the efficiency of activated carbon derived from jujube stones as a cost-effective adsorbent for the treatment of real textile wastewater.
Samaritan Israelites and Jews under the Shadow of Rome: Reading John 4:4–45 in Ephesus
Authors: Hunt Laura J.
Published: September 2023

Genealogies, knowledge, and purity all can provide separate identities with the means for competing self-definition. This article assumes a social location near Ephesus with Samaritan Israelites and Judeans in a Jesus-believing network. Rather than providing an analysis in which divisions are transcended, this reading suggests that a negotiation in John 4:4–45 of these three characteristics navigates divisions to create a complex, merged superordinate identity.
The End of Time and the Possibility of World: Between Divinity and Nature
Authors: Murchadha Felix Ó
Published: September 2023

Eschatology is central to Christian theology: the significance of the death and resurrection of Christ is the promise of the “kingdom of God”. This paper takes up this idea in discussion with contemporary Christian theologians and discusses it phenomenologically by recourse to Husserl’s account of “horizon”. The horizon is both finite and infinite: always limited in its actualization but with an infinity of potential actualizations. This is explored with respect to time and its relation to the eternal, as well as the dispositions of hope and fear with respect to the eschaton. The final section draws these insights together in a discussion of the eschaton to understand the eschatological destiny of nature in a “new heaven and a new earth” (Revelations, 21: 1) and conceiving of eschatological justice as a harmony of horizonal perspectives.
Paroxysmal Nocturnal Hemoglobinuria: A Case Report in a Pandemic Environment
Authors: Peixoto Vanda , Carneiro Ana , Trigo Fernanda , Vieira Mónica , Prudêncio Cristina
Published: September 2023

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, rare, complement-mediated hemolytic anemia. PNH can be associated with marrow failure and thrombophilia. We present a clinical report of splenic vein thrombosis in a patient with classic PNH. A 41-year-old male with classic PNH, naïve to complement inhibitor therapy, developed splenic vein thrombosis as a major adverse effect after vaccination protocol to prevent meningococcal disease. We also report anticoagulant and eculizumab treatment outcomes. In PNH patients, vaccination should be monitored to prevent major outcome events, like vaccine-induced thrombosis. Eculizumab proves effective for treating intravascular hemolysis and preventing more thrombotic events. The potential protective role of eculizumab on controlling complement activity and consequent inflammation may help the patient to not experience breakthrough hemolysis when infected with SARS-CoV-2. Extravascular hemolysis remains present, but new molecules are being studied to inhibit proximal complement and there is a good health prospective for PNH patients.
A Meso-Level Analysis of Factors Contributing to Freeway Crashes on Weekdays and Weekends in China
Authors: Liu Guangyu , Wang Shaohua , Zeng Qiang , Wang Xiaofei
Published: September 2023

This paper presents an empirical investigation of the factors contributing to freeway crashes on weekdays and weekends, using a Bayesian spatial logistic model. The crash data from Kaiyang Freeway, China, in 2014 are used for the empirical investigation. The deviation information criterion (DIC) values indicate that the proposed spatial logistic model is clearly superior to a logistic model in analyzing weekday and weekend crashes. Additionally, significant spatial effects are found in adjacent freeway segments for both weekday and weekend crashes, which demonstrate the reasonableness of the proposed model. The results of parameter estimation suggest that: traffic volume, roadway segment length, and the proportions of vehicles in Classes 2 and 4 have significant effects on weekday and weekend crash incidences in the same direction; horizontal curvature, presence of a ramp, and average daily precipitation impact weekday crash incidence only; and the proportion of vehicles in Class 3 and vertical grade impact weekend crash incidence only. Some countermeasures from the perspectives of roadway design and traffic management have been proposed to reduce freeway crashes on weekdays and weekends, respectively.
Exposure to Bisphenol A and Its Analogs among Thai School-Age Children
Authors: Numsriskulrat Nattakarn , Teeranathada Thanawan , Bongsebandhu-Phubhakdi Chansuda , Aroonparkmongkol Suphab , Choi Kyungho , Supornsilchai Vichit
Published: September 2023

Bisphenol F (BPF) and bisphenol S (BPS) have become popular substitutes for bisphenol A (BPA) in the plastic industry due to concerns over BPA’s adverse effects. However, there is limited information on children’s exposure to these chemicals. This study aims to assess the extent of BPA, BPF, and BPS exposure and determine factors that influence such exposure. A group of Thai children (age 6–13 years, N = 358) were recruited between October 2019 and 2020. Two first-morning voids were collected one week apart. Demographic and exposure-related information was gathered. Urinary concentrations of bisphenols were analyzed by liquid chromatography and tandem mass spectrometry. Correlation between bisphenol concentrations with age, body weight, and sources of bisphenol exposure, was determined using generalized estimating equations with linear model. BPA, BPF, and BPS were detected at 79.6%, 31.0%, and 16.8%, with geometric mean (GM) concentrations of 1.41, 0.013, and 0.014 ng/mL, respectively. Younger children aged <10 years exhibited 1.3–1.6 times higher GM levels of all bisphenols compared to older children. Exposure to food stored in plastic containers was associated with higher levels of BPF and BPS. In conclusion, BPA was the most frequently detected bisphenol in urine samples from Thai children, followed by BPF and BPS.