bluuebunny/crossref_metadata_2025 huggingface dataset:
Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
Authors: Yang Ting , Chao Kang , Zhu Xia , Wang Xue-Ding , Chan Sumyuet , Guan Yan-Ping , Mao Jing , Li Pan , Guan Shao-Xing , Xie Wen , Gao Xiang , Huang Min
Published: March 2024

BACKGROUND

Thiopurine-induced leucopenia significantly hinders the wide application of thiopurines. Dose optimization guided by nudix hydrolase 15 (NUDT15 ) has significantly reduced the early leucopenia rate, but there are no definitive biomarkers for late risk leucopenia prediction.

AIM

To determine the predictive value of early monitoring of DNA-thioguanine (DNATG) or 6-thioguanine nucleotides (6TGN) for late leucopenia under a NUDT15 -guided thiopurine dosing strategy in patients with Crohn’s disease (CD).

METHODS

Blood samples were collected within two months after thiopurine initiation for detection of metabolite concentrations. Late leucopenia was defined as a leukocyte count < 3.5 × 109/L over two months.

RESULTS

Of 148 patients studied, late leucopenia was observed in 15.6% (17/109) of NUDT15/ thiopurine methyltransferase (TPMT ) normal and 64.1% (25/39) of intermediate metabolizers. In patients suffering late leucopenia, early DNATG levels were significantly higher than in those who did not develop late leucopenia (P = 4.9 × 10-13). The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve (AUC) of 0.855 (sensitivity 83%, specificity 81%), and in NUDT15/TPMT normal metabolizers, the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902 (sensitivity 88%, specificity 85%). 6TGN had a relatively poor correlation with late leucopenia whether in the entire sample (P = 0.021) or NUDT15 /TPMT normal or intermediate metabolizers (P = 0.018, P = 0.55, respectively).

CONCLUSION

Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15 /TPMT normal and intermediate metabolizers with CD, especially the former.
Hepatic recompensation according to Baveno VII criteria via transjugular intrahepatic portosystemic shunt
Authors: Shaaban Hossam Eldin , Abdellatef Abeer , Okasha Hussein Hassan
Published: March 2024

Transjugular intrahepatic portosystemic shunt is a therapeutic modality done through interventional radiology. It is aimed to decrease portal pressure in special situations for patients with decompensated liver disease with portal hypertension. It represents a potential addition to the therapeutic modalities that could achieve hepatic recompensation in those patients based on Baveno VII criteria.
MODEL OF THE AERODYNAMIC SITUATION IN THE FURNACE OF A BOILER UNIT WITH ROTARY EJECTION BURNERS
Authors: Fedyaev Alexander Arturovich , Grigorieva Tatyana Anatolevna , Ulyanov Alexander Dmitrievich
Published: March 2024

A model of rational management of the aerodynamic environment in a pulverized coal boiler with different orientation of the combustion chamber air flow from the tail-end fuel feeding section was investigated. The study determined the optimal spatial parameters of the tail-end fuel feeding section and fuel consumption characteristics for different types of burners. These results helped to significantly reduce the risk of accidents caused by ineffective work of the tail-end fuel air flow control devices.
PROSPECTS OF THE USE OF CHITOSAN-BASED WOUND DRESSING FOR THE TREATMENT OF LIVER WOUNDS
Authors: Gumenyuk Sergey Evgenyevich , Ushmarov Denis Igorevich , Gumenyuk Alexander Sergeevich , Shokel Olga Yuryevna , Isianova Diana Rinatovna , Shevchenko Elizaveta Alexandrovna
Published: March 2024

The research of hemostatic and wound healing ability of two types of chitosan-based wound dressing under conditions of liver injury has been carried out in vivo. Acceleration of the time of final hemostasis, reduction of blood loss volume and probability of posthemorrhagic complications, as well as improvement of repair of damaged areas of liver parenchyma with biodegradation of the coating itself within a given period of time have been experimentally proved.
QIGONG “BA DUAN JIN” AS A MEANS OF HARMONY THE EMOTIONAL STATE OF UNIVERSITY STUDENTS
Authors: Yu Xian , Tupichkina Elena Aleksandrovna , Han Rui
Published: March 2024

In the article a brief introduction of Qigong “Ba Duan Jin” was given. The influence of Qigong “Ba Duan Jin” on the emotional states of university students was discussed from the perspectives of psychlogy, physiology and philosopy. It is theoretically proved that Qigong can be used as an effective means to harmonise the emotional state of students.
THE ECONOMIC COMPLEXITY INDEX OF THE DONETSK PEOPLE'S REPUBLIC
Authors: Polovyan Aleksey Vladimirovich , Sinitsyna Karina Igorevna
Published: March 2024

The article evaluates the export advantage of the goods of the Donetsk People's Republic. The index of economic complexity has been calculated and the place of the Donetsk People's Republic in the overall ranking of countries of the world has been determined. Industries and specific goods have been identified, the development of which should become a priority to ensure long-term economic growth.
INNOVATIVE UNIT FOR PREPARING THE SOIL FOR PLANTING RICE IN BURUNDI
Authors: Niyomuvunyi Angelos , Tarasenko Boris Fedorovich
Published: March 2024

This mechanized preparation unit is designed for small farms (0.3-0.5 hectares). In Burundi, more than 90% of the rural population earns their living from agriculture. they use primitive production techniques based on manual labor. This is a painstaking job that requires a lot of work. The introduction of medium-power motor cultivators and tools for them will significantly accelerate this transition from manual to mechanized labor.
ECONOMIC SECURITY OF THE REGION IN THE CONTEXT OF ANTI-RUSSIAN INTERNATIONAL SANCTIONS
Authors: Родина Елена Евгеньевна , Цыбенко Татьяна Викторовна
Published: March 2024

Введенные антироссийские международные санкции создают значительные вызовы для экономической безопасности региона. Эти меры охватывают различные аспекты, включая ограничения финансовой системы, деятельности ключевых российских компаний и отраслей экономики, а также персональные санкции против руководства и предпринимателей.

The introduced anti-Russian international sanctions create significant challenges for the economic security of the region. These measures cover various aspects, including restrictions on the financial system, the activities of key Russian companies and economic sectors, as well as personal sanctions against management and entrepreneurs.
STRESS TESTING AS A TOOL FOR FINANCIAL RELIABILITY OF AN ENTERPRISE
Authors: Родина Елена Евгеньевна , Матросов Данил Вячеславович
Published: March 2024

Статья представляет собой всесторонний обзор стресс-тестирования как ключевого инструмента в финансовом анализе для оценки устойчивости и надежности предприятий. В ней рассматриваются теоретические основы стресс-тестирования, включая его определение, историческое развитие и основные методологии.

The article provides a comprehensive overview of stress testing as a key tool in financial analysis for assessing the resilience and reliability of enterprises. It examines the theoretical foundations of stress testing, including its definition, historical development, and main methodologies.
ASSESSMENT OF CHANGES IN THE CAPITALIZATION OF THE COMPANY WHEN SELLING SHARES BY INVESTORS AT A DISCOUNT
Authors: Подосенов Тимофей Олегович , Кругляк Людмила Ивановна
Published: March 2024

Начиная с 2022 года на иностранных инвесторов из т. н. недружественных стран, имеющих ценные бумаги в российской депозитарной инфраструктуре, были наложены ограничения на свободную продажу ценных бумаг. При этом в частном порядке иностранные инвесторы могут осуществлять продажу с дисконтом по отношению к рыночной стоимости.

Starting in 2022, restrictions on the free sale of securities were imposed on foreign investors from so-called unfriendly countries with securities in the Russian depository infrastructure. At the same time, foreign investors can sell privately at a discount to the market value.
PROJECT «AUTOMATED SYSTEM FOR FINDING SOLUTIONS TO PROBLEMS IN SCHOOL EDUCATION»
Authors: Соловей Илья Исаакович
Published: March 2024

Описан новый подход к решению проблем в школьном образовании, основанный на методах социальной философии. Доказана достижимость полноты множества причин проблем. Показано, что включением средств управления проектами достигается максимально возможная вероятность удовлетворительного решения проблемы. Декларируется разработка стандарта «Решения социально-психологических проблем».

A new approach to solving problems in school education, based on the methods of social philosophy, is described. Completeness of many causes of problems has been proven to be achievable. It is shown that by including project management tools, the highest possible probability of a satisfactory solution to the problem is achieved. The development of the standard “Solutions to socio-psychological problems” is declared.
REFLECTIVE METHOD AS A TOOL FOR INCREASING PRODUCTIVITY OF PROJECT GROUPS
Authors: Каплунович Светлана Михайловна
Published: March 2024

В статье рассматривается проблема организации продуктивной деятельности проектных групп. В качестве одного из инструментов, способствующего продуктивной деятельности участников проектных групп рассматривается рефлексивный метод.

The article examines the problem of organizing the productive activities of project teams. The reflexive method is considered as one of the tools that promotes the productive activities of project group participants.
PROBLEMS OF BIOLOGICAL EVOLUTION: CRITICAL ANALYSIS
Authors: Карпин Владимир Александрович , Шувалова Ольга Ивановна
Published: March 2024

Теория биологической эволюции, несмотря на многолетние усилия мировой научной мысли, далека от своего логического завершения. Для решения ее важнейших проблем необходима предварительная разработка комплексной междисциплинарной научно-исследовательской программы. В статье представлен один из вариантов такой программы с привлечением философского метода законов и категорий материалистической диалектики

The theory of biological evolution, despite many years of efforts of the world scientific thought, is far from its logical conclusion. To solve its most important problems, preliminary development of a comprehensive interdisciplinary research program is necessary. The article presents one of the variants of such a program involving the philosophical method of laws and categories of materialistic dialectics.
ANALYSIS OF CHANGES IN THE COMPOSITION OF PERIPHERAL BLOOD DEPENDING ON AGE AND GENDER
Authors: Морякина Светлана Васильевна , Мусиханова Зара Баудиевна , Сайдэминова Элина Зайндиевна
Published: March 2024

В научной статье изложены исследования возрастных особенностей общего анализа крови у представителей Чеченской Республики на основе данных гематологического анализатора. В результате было установлено понижение уровня эритроцитов у мужчин пожилого и преклонного возраста (группа 6 - 70-79 лет и группа 7 - старше 80 лет). У обследованных жителей Чеченской Республики мы отметили постепенное возрастное повышение скорости оседания эритроцитов. Содержание лейкоцитов в молодом и пожилом возрасте несколько отличается. Со стороны концентрации лейкоцитов отмечена тенденция к понижению сообразно возрасту.

The scientific article presents studies of age-related characteristics of a general blood test among representatives of the Chechen Republic based on data from a hematological analyzer. As a result, a decrease in the level of red blood cells was found in elderly and elderly men (group 6 - 70-79 years old and group 7 - over 80 years old). In the examined residents of the Chechen Republic, we noted a gradual age-related increase in the erythrocyte sedimentation rate. The content of leukocytes in young and old age is somewhat different. In terms of leukocyte concentration, there was a tendency to decrease in accordance with age.
FINANCIAL INSTRUMENTS OF THE “GREEN ECONOMY” IN THE ASPECT OF ISLAMIC BANKING
Authors: Бурмистрова Лариса Алексеевна
Published: March 2024

Рассматриваются научные понятия, касающиеся инструментов «зеленой экономики» в исламской финансовой системе, такие как зеленый сукук, проблемы использования инструментов финансирования «зеленой экономики» в мире и оригинальность их в исламских финансах в условиях экономического кризиса и основ Макасид аш -Шариата
MUHAMMAD SHAIBANI KHAN: THE LEGACY OF A RENAISSANCE RULER
Authors:   Jizzakh State Institute of Pedagogy named after A. Qadiri, Faculty of History, Associate Professor of the Department of History Teaching Methodology, Honored Public Education Officer of the Republic of Uzbekistan, Nurkulova R.R.
Published: March 2024

Muhammad Shaibani Khan, a prominent Central Asian ruler of the 15th and 16th centuries, left an indelible mark on the region's history through his strategic conquests, administrative acumen, and diplomatic engagements. Rising from humble beginnings, Shaibani Khan established the Shaibanid dynasty and consolidated his authority over vast territories in Transoxiana. His reign was characterized by military campaigns against rivals such as the Safavids and the Shaybanids, as well as by policies of religious tolerance and cultural flourishing. This article explores the life, achievements, and lasting legacy of Muhammad Shaibani Khan, shedding light on his pivotal role in shaping the political and cultural landscape of Central Asia.
A LOOK INTO THE HISTORY OF STUDYING THE CONCEPTS OF "JOY" AND "SADNESS"
Authors:   Doctoral Candidate at Andijan State University,Uzbekistan, Rejapova Moxlaroy Farxodbek qizi
Published: March 2024

This article delves into the significance of studying emotions, specifically the concepts of "joy" and "sadness" within the realm of conceptual research, from the perspective of linguists. The paper reflects on the salient points of scientific approaches by German, Polish, and Iranian scholars on this topic. The contributions of Russian and Uzbek linguists to this field are also discussed in the context of conceptual studies.
THE STUDY OF THE CONCEPT OF ALOGISM IN A CHRONOLOGICAL PERSPECTIVE
Authors:   PhD student of Andijan State Foreign Languages Institute, Andijan, Uzbekistan, Samatova Zulxumor Q.
Published: March 2024

This article delves into data related to one of the most pivotal branches of stylistics in terms of “alogism”.
Exploring Basic Writing Aspects of Elementary Students: Based on Error Analysis of a Sentence Dictation Test of Second-Grade Students
Authors:   Korean Association for Literacy, Lee Yongjun , Kim Kyounghwan
Published: March 2024

Severaessary.
Digital-Based Collaborative Reading-Writing Performance of Elementary School Students
Authors:   Korean Association for Literacy, Kim Chaeeun , Kim Seyeon
Published: March 2024

Thation.
Writing Education for Sutainable Life: Focusing on the Possibility of Reflection and Value of Communication through writing
Authors:   Korean Association for Literacy, Jang Ji-hye
Published: March 2024

Thisners.
Conceptualization of security contradictions in the postmodern era: phenomenological aspect
Authors: DZIOBAN O. , FIVKIN Р.
Published: March 2024

The problem of security is analyzed taking into account the postmodern transformation of the concepts of “human”, “society”. The main focus is on the correlation of the understanding of the security problem with the understanding of the “Other”. It is shown that the understanding of security in postmodern culture goes beyond the usual understanding of the problem of threats and dangers. At the level of the conceptual understanding of security and the cultural and anthropological analysis of security as a phenomenon, the question of the subject’s relationship with the “Other” in its various guises is raised.
Existential definition of the paradigm of legal regulation of the use of artificial intelligence
Authors: BARANOV O.
Published: March 2024

The article is devoted to the problems of legal regulation of the development and application of artificial intelligence technologies in the world and in Ukraine. An overview of the main international and national initiatives aimed at solving the problem of forming sustainable governance and regulating the development and application of artificial intelligence technologies is carried out, as well as the results of the discussion of the possibilities of artificial intelligence and the risks associated with its use for peace and security, economy and society, and human rights are highlighted. The results of the analysis of the current state of affairs in the field of artificial intelligence are obtained. There is uncertainty, divergence of views of political, intellectual and business elites both at the national and global levels regarding the conceptual content of further ways to determine the legal regulation of artificial intelligence. The world is faced with the phenomenon of the singularity, which requires the definition of a new paradigm and conceptual framework for the transformation of legal systems, first of all, the regulatory framework for the effective development and application of artificial intelligence technologies.
Legal regulation of artificial intelligence in the European Union and Ukraine: main approaches and human rights
Authors: TARAN O. , HAVLOVSKY V.
Published: March 2024

The article provides an analytical review of a number of international and national documents relating to various aspects of the legal regulation of artificial intelligence. Attention is focused on the problems of regulatory and practical approaches to ensuring and observing human rights at all stages of the life cycle of artificial intelligence.
Formation and analysis of networks of events in the field of parliamentary control based on the application of artificial intelligence systems
Authors: LANDE D.
Published: March 2024

The article introduces a methodology for forming and analyzing the network of events in news reports related to parliamentary control. This methodology relies on the application of generative artificial intelligence, and the article provides examples of its practical implementation. The revolution in artificial intelligence enables the solution of tasks not only related to identification but also to the formation of causal networks of events, where the causes and consequences are clearly presented. The utilization of large linguistic models has yielded convenient methods for extracting events from texts, filtering them, and clustering. Artificial intelligence is employed for identifying cause-and-effect relationships, significantly simplifying the processing of natural language. Visualization and cluster analysis of the formed networks can be performed using traditional tools for network analysis.
The current trends of regulatory support of institutional formation of cybertroops (cyber force): the experience of certain NATO countries
Authors: FEDIENKO O.
Published: March 2024

The general trends of the institutional development of cybertroops (cyber forces) in certain NATO countries (Great Britain, the USA) are determined. Regulatory documents, devoted to the formation of cybertroops in these NATO member countries have been analyzed. The competence, powers and functional tasks of practical activities of cyber units are considered. The content and significance of the cognitive effect doctrine and the consequences of its use are outlined. The peculiarities of the use of cyber troops in the framework of conducting defensive and offensive cyber operations are summarized. The achievements and examples of successful activities of the cyber forces of Great Britain and the United States are detailed. On the basis of the generalization of positive foreign experience in the creation of cyber forces, the prospects of legislative support for the institutional formation of cyber forces in Ukraine are outlined.
Regulation of the international legal status of journalists during the war
Authors: SKUTELNYK O.
Published: March 2024

The article highlights the problems of the legal status of journalists and their protection during the war on the basis of international legal acts. Attention is focused on the norms of the Geneva Convention of 1949 and its Additional Protocols, which regulate the status of journalists during armed conflicts. Attention is focused on the fact that it is necessary to distinguish two categories of journalists: war correspondents and independent journalists, which are considered separately, and war correspondents are protected by the armed forces, and independent journalists do not have such special protection. It is noted that international humanitarian law considers journalists working in areas of armed conflict as civilians subject to the protection by Geneva Conventions and their Additional Protocols. Deficiencies in the protection of journalists in the context of considering them as ordinary civilians are pointed out. The possibility of creating a single special international legal act is being considered, which will determine the legal status of journalists during their stay in combat zones, taking into account their important mission of conveying true information to society and the functions they perform at the same time. Attention is focused on the need to identify journalists, provide assistance and protection by states, ensure free movement of journalists and respect the confidentiality of their sources. The importance of investigating cases of violence or deaths of journalists was emphasized.
Peculiarities of the evolution of military justice in NATO member states
Authors: BELANIUK M.
Published: March 2024

The article highlights the specifics of the evolution of military justice of NATO member countries for the possible consideration of the experience of these countries in the course of restoring the military justice system in Ukraine, taking into account its aspirations for full membership in the North Atlantic Alliance.
Restoration of the military prosecutor’s office as an element of the system of military justice bodies of Ukraine
Authors: SHAMARA O.
Published: March 2024

The article examines the creation (restoration) of the military prosecutor’s office, as an integral element of the system of military justice bodies of Ukraine, in the conditions of the legal regime of martial law and a special period, based on the results of the analysis of draft laws of the Parliament of Ukraine and the experience of the operation of the military prosecutor’s office in NATO member countries.
APLIKASI GAME EDUKASI BELAJAR MENGHAFAL AYAT-AYAT PENDEK BERBASIS ANDROID MENGGUNAKAN METODE INTERPOLATION SEARCH (STUDI KASUS : TK SULAMUL ULUM)
Authors:   Universitas Lancang Kuning, Hardianto Roki , Listianingrum Ajeng , Ningsih Eva Tri ,   Universitas Lancang Kuning,   Universitas Lancang Kuning
Published: March 2024

This research produces output in the form of android-based educational games that can be used in early childhood learning. The results of testing on students illustrate that games can motivate students in learning, especially the introduction of short verses. The interpolation search method helps users search for short verses to be learned.
VISUALISASI DATA LOKASI RAWAN BENCANA DI JAWA TENGAH MENGGUNAKAN POWER BI
Authors:   Universitas Semarang, Adesyahputra Muh Kevin , Febrianto Ricky ,   Universitas Semarang, Wibowo Muhammad Nanang Khilmi , Handayani Titis
Published: March 2024

The Central Java Province, as a disaster-prone region, faces risks due to both natural and human factors. Low awareness of disaster risks and insufficient mitigation efforts worsen the situation. This research utilizes Power BI to visualize disaster data, contributing to the understanding of risks. A quantitative method is employed with a focus on data analysis, collected from the Indonesian Disaster Risk Index. The data blending and cleaning phase ensure dataset quality and relevance before implementation into Power BI. An interactive dashboard is created with graphics such as tables, bar charts, and donut charts. Evaluation and analysis of the results are conducted to ensure the effectiveness of the visualizations. The findings indicate that forest fires are the most dominant disaster, followed by floods and landslides. Volcanic eruptions have the lowest frequency. Recommendations include enhancing preparedness for forest fires, in-depth analysis of disaster causative factors, periodic data updates, and improved collaboration among stakeholders.
INOVASI EDUKASI: AUGMENTED REALITY UNTUK TATALAKSANA JENAZAH DALAM KONTEKS ISLAM
Authors:   Fakultas Ilmu Komputer, Universitas Muhammadiyah Riau, Resiasa Maskuri , Unik Mitra ,   Fakultas Ilmu Komputer, Universitas Muhammadiyah Riau
Published: March 2024

This research successfully addresses the complexity of handling corpses within an Islamic framework through the application of educational innovations using Augmented reality (AR) technology. The AR Jenazah application was developed with a focus on increasing understanding and skills in corpse handling procedures, which are in accordance with religious teachings and ethical norms. The results of black box testing showed the reliability of the application's functionality and presentation, while beta testing with the participation of 20 general public respondents gave positive conclusions on user interest, teaching, ease of use, and application performance. This research makes an important contribution to the development of a modern educational approach in understanding and implementing corpse handling procedures in an Islamic context. The AR Jenazah application was not only technically successful, but also achieved positive user acceptance, signalling its potential positive influence in improving the quality of learning and practice of corpse handling. Suggestions for development involve expansion of educational content, expert and user engagement, adoption to other platforms, evaluation of long-term impact, development of interactive features, multi-language versions, and collaboration with educational and religious institutions. These improvements are expected to strengthen the educational value of the app and expand its positive impact in the wider community.
QUIMIOTERAPIA METRONÔMICA EM UM GATO COM CARCINOMA DE CÉLULAS ESCAMOSAS
Authors: Chalco Lorena , Sánchez Robert , Guerrero Ana , Apolo Guido , Pires Claudina
Published: March 2024

Background: Squamous cell carcinoma (SCC) is a malignant neoplasm associated with prolonged exposure to ultraviolet light and lack of skin pigment in white-coated animals. The disease diagnosis is based on the animal's history, clinical signs and histopathology of the samples collected. The therapeutic alternatives are diverse. Among them, one of the most used is the metronomic chemotherapy which is based on the use of cytostatics drugs, applied in low and frequent doses for a longer period of time. One of the mechanisms of action of this type of therapy is the decrease in angiogenesis. Non-steroidal anti-inflammatory drugs (NSAIDs) are simultaneously used to maximize the angiogenic effect. The objective of this study is to report the results of a treatment accomplised with metronomic chemotherapy (cyclophosphamide with meloxicam) in a domestic feline which presented a squamous cell tumor. Case: A female domestic feline, mixed breed, not neutered, weighing 3.5 kg, about 7 years old, was assisted at the Veterinary Specialties Teaching Clinic (CEEV) of the Technical University of Machala (UTMACH), presenting bilateral ulcerative lesion in the nasal plane for 5 months. Chronic exposure to sunlight is referred to in the patient's anamnesis. Aspiration cytology performed in the patient revealed an inflammatory process with a predominance of neutrophils and macrophages, and showed absence of neoplastic cells. A treatment based on antibiotics and corticosteroids was adopted. Discussion: The diagnosis of squamous cell carcinoma was based on clinical and histopathological findings. The macroscopic lesions were crusted ulcers that do not heal in the nasal plane and auricular pavilion, as reported in the literature. SCC is characterized by the infiltration of squamous cells in the dermal layer of the skin, forming epithelial islands with keratin pearls. The histopathological findings of this case present the same characteristics. The climatic conditions of Ecuador, high temperatures with greater incidence of sunlight, hypopigmented areas of the animal's body and chronic exposure to solar radiation are risk factors present in this case that foster the development of this malignant neoplasm. There are multiple treatments to be introduced in this sort of pathology. In this case, surgical removal of the tumor was adopted, followed by metronomic chemotherapy based on cyclophosphamide at 10 mg/m2 and meloxicam at a 0.05 mg/kg per day for a period of time of five months, obtaining favorable results and absence of recurrence. Despite metronomic chemotherapy being easy to administer, with fewer side effects, which includes a better acceptance of care takers who are reluctant to administer conventional chemotherapy, further studies are still necessary in what concerns certain variables such as age, carcinoma level, appropriate dosages and drugs according to each neoplasm.
CORRELAÇÃO ENTRE CAPACIDADE PARA O TRABALHO, QUALIDADE DE VIDA E SONOLÊNCIA DIURNA DE FISIOTERAPEUTAS ATUANTES EM UNIDADES DE TERAPIAS INTENSIVAS DURANTE A PANDEMIA DO COVID-19
Authors: Vieira Lima Júnior Francisco Assis , Lôbo de Carvalho Victoria Vivian , Medeiros de Lima Maria Luiza , Cavalcante Marinho Ravel , Guerra Azevedo Ingrid
Published: March 2024

Introdução: Durante a pandemia do COVID-19 os profissionais fisioterapeutas estiveram atuando na linha de frente ao redor do Brasil e do mundo. Sendo assim, encontrou-se de extrema importância a avaliação da qualidade de vida, questões relacionadas ao sono e à capacidade para o trabalho dos fisioterapeutas que atuaram nas unidades de terapia intensiva brasileiras. Objetivo: Avaliar a capacidade para o trabalho, a qualidade de vida e a sonolência diurna de fisioterapeutas que atuaram na linha de frente contra a COVID-19 nas Unidades de Terapia Intensiva (UTIs) do Brasil. Métodos: Estudo descritivo, quantitativo e transversal. Todas as etapas da pesquisa foram realizadas de forma virtual através da plataforma Google Forms. Para avaliar a capacidade de trabalho dos participantes, utilizou-se o Índice de Capacidade para o Trabalho (ICT), validado para o Brasil. Para a avaliação subjetiva da sonolência diurn foi utilizada a Escala de Sonolência de Epworth (ESE) e para a qualidade de vida, foi aplicado o questionário 12-Item Short-Form Health Survey (SF-12). Os dados foram analisados pelo SPSS versão 25. Resultados: Aamostra composta por 44 fisioterapeutas intensivistas (idade: 29,25 ± 6,94 anos) maioria do sexo feminino (72,7%), solteiros (52,3%), grande parte residentes na região nordeste (72,6%) e com tempo de formação em sua maioria entre 1-5 anos (65,7%). Os sujeitos apresentaram uma boa capacidade para o trabalho e pouca sonolência diurna. Foi observada uma correlação grande e inversa entre o ICT e sonolência diurna (r = -0,514; p < 0,001). Não houve correlação significativa entre o ICT e o componente físico do SF-12 (r = 0,287; p = 0,059). Foi encontrada correlação grande e direta entre ICT e o componente mental do SF-12 (r = 0,502; p = 0,001). Foi verificada uma correlação moderada e inversa entre sonolência diurna e o componente físico e mental do SF-12 (r = -0,347; p = 0,021; r = -0,300; p = 0,049, respectivamente). Conclusão: A amostra apresentou pouca sonolência diurna e boa capacidade para o trabalho, com correlação moderada e inversa entre os níveis de sonolência diurna e os domínios físico e mental de qualidade de vida. Foi encontrada uma correlação grande e inversa entre a sonolência diurna o ICT. Ao correlacionar o ICT com a qualidade de vida, apenas para o nível mental apresentou uma relação significativa, sendo grande e direta.
REGENERACIÓN DE ESPECIES ARBÓREAS Y ARBUSTIVAS DESPUÉS DE UN AÑO DE MONITOREO EN UN MATORRAL ANDINO ECUATORIANO
Authors: Muñoz Luis , Giron Mitzi , Muñoz Johana , Aguirre Zhofre
Published: March 2024

Los incendios forestales, dependiendo de la intensidad y severidad, pueden generar cambios en la vegetación como el reemplazo de árboles por arbustos y hierbas. El objetivo de esta investigación fue evaluar, en un periodo de un año, el estado de la regeneración de árboles y arbustos en un matorral andino que fue afectado por un incendio forestal en el año 2017, en el Parque Universitario “Francisco Vivar Castro”. La primera medición se realizó entre octubre a diciembre 2021, siendo esta la base de comparación; y la segunda medición un año después. Se estudió las categorías de regeneración plántulas, brinzal y latizal dentro de parcelas permanentes, a una escala local. Se evaluaron variables de composición, diversidad, crecimiento en altura, sobrevivencia, reclutamiento y el paso de individuos entre categorías. La regeneración del matorral presentó cambios no significativos en diversidad y composición florística. Se evidenció crecimiento en altura en todas las categorías estudiadas sin ser estadísticamente significativo. La sobrevivencia de arbustos y árboles fue de 91 %. En la categoría plántulas se registró el reclutamiento de 3 árboles y 8 arbustos, siendo Baccharis cf obtusifolia y Dendrophorbium scytophyllum las de mayor aporte. El mayor paso de individuos de regeneración fue desde la categoría plántulas a brinzal. En el año de evaluación, la regeneración del matorral andino reveló cambios no significativos en todas las variables evaluadas, lo que sugiere que el monitoreo debe ser constante y a largo plazo para comprender cómo cambia la vegetación posterior a un incendio.
A IMPORTÂNCIA DO GESTOR HOSPITALAR: UM ESTUDO DE CASO NO HOSPITAL MUNICIPAL
Authors: ARAUJO A. L. , FAHD P. G , CRUZ M.S.P
Published: March 2024

Objetivo: analisar a relevância do gestor no ambiente hospitalar frente aos requisitos necessários e às competências atinentes ao seu gerenciamento nas organizações hospitalares. O estudo contextualiza a importância do gestor hospitalar e destaca os desafios para a atuação das hegemonias para lidar com a dimensão do conflito existente entre as subculturas médica, de enfermagem e administrativa. Métodos: Trata-se de pesquisa de estudo de caso; quanto aos objetivos é descritiva, quanto à forma de abordagem do problema é qualitativa e quantitativa. A amostra envolveu trinta e sete profissionais da organização. Resultados: Os dados indicam que os conflitos entre as subculturas são derivados das formas de controle do trabalho, divergência de interesses e desigualdade de tratamento social. Nesse sentido, a atuação do gestor hospitalar deve deslocar-se de uma perspectiva do comando e controle para outra mais subjetiva, como a construção de relações de confiança, a mediação ou ainda a atribuição de significado para a ação dos liderados. A ênfase do processo de gestão estaria apoiada na construção de relações de alteridade, entre sujeitos, orientada por processos de diálogo e negociação. Conclusão: A guisa de entendimento, constatou-se que o processo de aprendizagem enfatiza a aprendizagem individual e não a aprendizagem organizacional.
IMPACTOS DA PANDEMIA: COMPLICAÇÕES E SEQUELAS DA COVID-19 NA SOCIEDADE E NOS PROFISSIONAIS DE ENFERMAGEM
Authors: Lemos Antônia Gildevania , Damasceno Claudiene Gomes , Oliveira Maria Gleicilane , Silva Maria Jocielma da , Paiva Jocilene da Silva , Lima Ana Marília Ancelmo Oliveira , Costa Edmara Chaves , Queiroz Terezinha Almeida , Silva Maria Adriana Martins e , Gomes Keyse Hadra Queiroz
Published: March 2024

A pandemia de Covid-19, causada pelo vírus SARS-CoV-2, tem afetado o mundo inteiro desde o final de 2019. A doença pode variar de leve a grave, e muitos pacientes apresentam complicações e sequelas após a recuperação. O presente estudo tem como objetivo revisar a literatura científica sobre as complicações e sequelas da Covid-19 na sociedade e nos profissionais de enfermagem. Trata-se de uma revisão narrativa da literatura. Foram utilizadas as bases de dados PubMed, Scopus e Web of Science, com os seguintes termos de busca: "Covid-19", "Complicações", “Sequelas” e “Pandemia”. Foram incluídos estudos publicados entre janeiro de 2020 e junho de 2021, em inglês, espanhol e português. Como resultado tem-se que, as complicações mais comuns incluem pneumonia, síndrome do desconforto respiratório agudo, trombose venosa profunda, embolia pulmonar, insuficiência renal aguda, arritmias cardíacas e lesão hepática. As sequelas mais comuns incluem fadiga, dispneia, dor torácica, perda de olfato e paladar, ansiedade, depressão, distúrbios do sono e disfunção cognitiva. Além disso, nota-se que a Covid-19 pode causar complicações e sequelas graves e duradouras. Com isso, é importante que os profissionais de saúde estejam cientes dessas complicações e sequelas para fornecer um tratamento adequado e monitorar os pacientes após a recuperação. Ademais, enfatiza-se a necessidade de mais estudos que abordem as complicações e sequelas da Covid-19 no âmbito da equipe de enfermagem bem os desafios e enfrentamentos da categoria.
O PROCESSO DE TERRITORIALIZAÇÃO DAS EMPRESAS TRANSNACIONAIS NOS PAÍSES INDUSTRIALMENTE SUBDESENVOLVIDOS: NOS PAÍSES INDUSTRIALMENTE SUBDESENVOLVIDOS
Authors: Santos Roberto , BATISTA NELSONITA DE SOUZA
Published: March 2024

A estruturação e elaboração deste artigo basearam-se a partir de uma revisão bibliográfica. Procura debater teórico-criticamente a gestão territorial das empresas multinacionais nos países subdesenvolvidos industrialmente. Discutir e questionar a forma neocolonial adotada pelos países capitalistas no atual mundo globalizado. Debater sobre como as empresas multinacionais estabelecem o processo de territorialização. Abordar sobre o modelo de planejamento adotado no desenvolvimento regional no século XX. Questionar e debater de forma crítica o processo de neocolonialismo. No mundo atual, as empresas multinacionais acionam o processo de territorialização através de estratégias e articulações políticas, parcerias, alianças, tendo como parceiros/instrumentos o conhecimento técnico-científico. No seu processo de territorialização tem o controle e domínio comercial e político do mercado na arena global regional e local. Quando elas territorializam, criam novos hábitos alimentares e novos estilos de consumo e de vida. No processo de territorialização, as empresas multinacionais desterritorializam os atores locais e se territorializam nos lugares, nas localidades.
CONTRIBUIÇÕES DE UM PROJETO DE EXTENSÃO PARA O FORTALECIMENTO E AMPLIAÇÃO DA LINHA DE CUIDADO EM OBESIDADE NO CONTEXTO DA PANDEMIA DE COVID-19
Authors: Ferreira Ana Paula Ribeiro , Jesus Cesar Bezerra de , Moreira Daniela Farias , Pires Evelly Dias , Louro Luana Santos , Mello Sanna Abigail de Jesus , Pompermayer Vinicius Augusto Rocha
Published: March 2024

INTRODUÇÃO: A obesidade é um problema de saúde pública e, com a pandemia de COVID-19, houve um aumento nos seus fatores de risco. Apesar da importância do tema, ainda há dificuldade no manejo da obesidade na atenção primária. Nesse contexto, o projeto de extensão “Fortalecimento e ampliação da linha de cuidado em obesidade na rede pública de saúde no Espírito Santo”, tem como objetivo capacitar profissionais da saúde da atenção primária, e secundária, sobre o manejo à pessoa com obesidade. MÉTODO: Realização de eventos, cursos de capacitação, ações sociais, acompanhamento de equipe multiprofissional em ambulatório, formações e divulgação de conteúdo em redes sociais. RESULTADOS: O curso ministrado teve mais de 4000 visualizações; as ações sociais tiveram grande participação da comunidade; a vivência dos estudantes nos ambulatórios contribui para a formação dos acadêmicos; as reuniões auxiliam na fundamentação teórica e o conteúdo das redes sociais favorece a educação permanente em saúde. DISCUSSÃO / CONCLUSÕES: O projeto cumpre seu objetivo extensionista ao possibilitar a troca de saberes, contribuindo com a formação continuada de profissionais de saúde, sensibilização da população, e com a formação de estudantes, ao fortalecer e ampliar a linha de cuidado em obesidade.
IMPACTO DA ATUAÇÃO DO FARMACÊUTICO NO COMBATE À COVID-19: ESTUDO DA PARTICIPAÇÃO NA EQUIPE MULTIDISCIPLINAR EM UM HOSPITAL PRIVADO DE CAMPO GRANDE/MS
Authors: Costa Lavínia Juliana Silva , Prado Thais Keli Almeida , Roriz Nathália Franco , Bogo Danielle
Published: March 2024

Objetivo: O objetivo desta pesquisa foi examinar o envolvimento do farmacêutico clínico no atendimento farmacoterapêutico de pacientes graves com COVID-19 em um hospital privado localizado em Campo Grande, Mato Grosso do Sul. Métodos: O estudo adotou uma abordagem descritiva-observacional de cunho quantitativo, baseada em pesquisas bibliográficas. Foram avaliadas as terapias medicamentosas e os distúrbios decorrentes da coadministração de diferentes medicamentos pelos pacientes. A análise incluiu uma avaliação minuciosa das repercussões clínicas, com foco na atuação proativa do farmacêutico clínico dentro da equipe multidisciplinar. Resultados: Os resultados ressaltaram a importância do envolvimento do farmacêutico clínico no aconselhamento sobre a seleção da abordagem terapêutica mais adequada, levando em consideração os possíveis riscos e vantagens para pacientes individuais. Foram detectados vários casos em que a intervenção do farmacêutico desempenhou um papel vital na garantia da segurança dos medicamentos prescritos e na melhoria dos resultados clínicos. Conclusão: Diante da complexidade da gestão farmacoterapêutica de pacientes graves com COVID-19, a atuação do farmacêutico clínico se mostrou essencial para garantir uma abordagem terapêutica adequada e segura. Sua participação ativa na equipe multidisciplinar contribuiu significativamente para a melhoria da qualidade do cuidado aos pacientes, ressaltando a importância de sua presença nos ambientes hospitalares durante a pandemia.
The Effect of Fear of COVID-19 on the Birth Preferences of Pregnant Women
Authors: Yıldız Karaahmet Aysu , Bilgiç Fatma Şule
Published: March 2024

Deciding on the mode of birth related to the pregnant woman's own body will increase her self-confidence. It will reduce the anxiety caused by the adverse conditions caused by the pandemic process. It was aimed to examine the effect of fear of COVID-19 on the birth preferences of pregnant women.

A descriptive cross-sectional study was conducted between January and April 2021 with 631 pregnant women who were followed up in an crowded pandemic hospital in Turkey. The data were obtained through the Google online platform, the Questionnaire Form and the COVID-19 Fear Scale.

This study 50.7% of the pregnant women gave vaginal birth before the COVID-19 pandemic, while 75.3% preferred vaginal birth during the pandemic. When the table is examined, the mother's fear of COVID-19 increased her choice of delivery method 96%.

According to the findings of this study, fear of COVID-19 affected birth choice.
The Effect of Parents' Nutritional Practices on Children's Eating Behaviors
Authors: Özbey Yücel Ümüş , Uçar Asli
Published: March 2024

It is known that parents' feeding practices have an important effect on children's health, and children learn nutrition by imitating their parents. In this study, it was aimed to examine the effects of parents' nutritional practices on the eating behaviors of children attending pre-school education.The sample of the study consisted of the parents of 206 children aged 3-6 who were educated in kindergartens. The data related to the research were obtained with a questionnaire form. Parents' statements were taken as basis in obtaining nutritional and anthropometric data of parents and children. 85.9% of the parents participating in the study were mothers. As the education level of the parents increased; the controlled feeding scores increased, while the emotional feeding scores decreased (p
Hemşirelik Öğrencilerinin Psikolojik İlk Yardım Uygulama Öz yeterlik Düzeyleri ve Mental İyi Oluşlarının Belirlenmesi: Çok Merkezli Tanımlayıcı Bir Çalışma
Authors: Yanık Derya , Ediz Çiçek
Published: March 2024

Bu çalışma, hemşirelik öğrencilerinin psikolojik ilk yardım uygulama öz yeterlik düzeyi ve mental iyi oluşlarının belirlenmesi amacıyla gerçekleştirildi. Tanımlayıcı tipte tasarlanmış olan bu araştırmada hedef nüfus, Türkiye’nin farklı coğrafi bölgelerinde bulunan ve hemşirelik lisans eğitimi veren yedi üniversitenin hemşirelik bölümü öğrencileridir. Araştırma, 422 hemşirelik öğrencisinin katılımı ile tamamlandı. Araştırma verileri Demografik Bilgi Formu, Psikolojik İlk Yardım Uygulama Özyeterlik Ölçeği ve Warwick-Edinburgh Mental İyi Oluş Ölçeği kullanılarak toplandı. Veriler; sayısı (n), yüzde (%), aritmetik ortalama (±), standart sapma (ss) değerleri ile bağımsız örneklerde t testi, ANOVA ve Pearson korelasyon testi ile değerlendirildi. Araştırmamıza katılan öğrencilerin %60,7’sinin daha önce herhangi bir afet yaşadığı ve daha önce afet yaşayan öğrencilerin %89,5’inin yaşadığı afetin deprem olduğu belirlendi. Çalışmamızda, hemşirelik öğrencilerinin Psikolojik İlk Yardım (PİY) uygulama öz yeterlikleri ile PİY eğitimi alma durumları ve eğitim gördükleri üniversite arasında ilişki olduğu saptandı. Hemşirelik öğrencilerinin mental iyi oluşları ile cinsiyet, eğitim görülen üniversite, daha önce herhangi bir afet yaşama ve PİY eğitimi alma durumları arasında ilişki olduğu bulundu. Çalışmada, öğrencilerin PİY uygulama özyeterliği ile mental iyi oluşları arasında (r= 0.533, p< 0.001) pozitif yönde ve orta düzeyde ilişki olduğun belirlendi. Afet yönetimi hazırlığında, hemşirelik öğrencilerine psikolojik ilk yardım eğitiminin verilmesi ve böylece onların psikolojik ilk yardım uygulama öz yeterliğinin ve mental iyi oluşlarının güçlendirilmesi önem taşımaktadır.
Özel ve Kamu Hastanelerinde Stratejik İnsan Kaynakları Yönetimi ve Çalışan Performansı İlişkisi
Authors: Özşahin Figen , Öztürk Zekai
Published: March 2024

Bu çalışmanın amacı, Trabzon ilindeki devlet ve özel hastanelerdeki sağlık çalışanlarının stratejik insan kaynakları yönetimi, çalışan performansı ve çalıştıkları hastane sektörü arasındaki ilişkilerin incelenmesidir. Bu iki konunun birbirleri ile ilişkilerinin ortaya konulmasının sağlık kurumları açısından rekabet avantajı elde etmede ve küresel rekabette ayakta kalabilmek için önemli katkılar sağlayacağı öngörülmektedir. Araştırmanın yapısal eşitlik modellemesinde (YEM), hastane sektörü dışsal (exogenous), iş perfromansı içsel (endogenous) ve stratejik insan kaynakları yönetimi ise aracı (mediator) değişken olarak yer almaktadır. Araştırma, Trabzon ilinde bulunan il sağlık müdürlüğüne bağlı devlet ve özel hastanelerde aktif olarak görev yapan 6106 sağlık çalışanından 590 sağlık çalışanına ulaşılarak gerçekleştirilmiştir. Çalışmada kolayda örnekleme yöntemi kullanılmıştır. Araştırma modeli betimsel ve ilişkisel tarama modelidir. Stratejik insan kaynakları ve iş performansı arasında istatistiksel olarak pozitif yönlü anlamlı bir ilişki bulunmuştur. Bu araştırmanın yapısal eşitlik modeli aşamasında öncelikle ölçme modeli, ardından yapısal model test edilmiştir. Sonrasında yapısal modeldeki aracılık ilişkisi için Boostrapping testi kullanılmıştır. Aracılık testi sonucunda stratejik insan kaynakları yönetiminin, hastane sektörü ile iş performansı arasındaki ilişkiye tam aracılık ettiği görülmüştür. Araştırmanın doğrulanan modelinde iş performansına ilişkin toplam varyansın %42’sinin açıklandığı belirlenmiştir. Hastanelerin iş performanslarını artırmak için staratejik insan kaynakları yönetiminin geliştirilmesi gerektiği önerilmiştir.