bluuebunny/crossref_metadata_2025 huggingface dataset:
Visceral Debranching for the Treatment of Thoracoabdominal Aortic Aneurysms
Authors: Damrauer Scott , Fairman Ron
Published: February 2019

Based on a Presentation at the 2013 VEITH Symposium, November 19–23, 2013 (New York, NY, USA)

Surgical repair of thoracoabdominal aortic aneurysms (TAAA) is associated with significant morbidity and mortality. Hybrid approaches that involve visceral debranching and aortic endografting allow for an alternative approach in certain high-risk patients. In most circumstances the visceral vessels can be bypassed in a retrograde manner from the iliac arteries via a midline laparotomy, and the aortic aneurysm subsequently excluded with standard aortic endografts. These procedures avoid the extensive two-cavity exposure, aortic cross-clamping, and mechanical circulatory support that comprise open TAAA repair, and offer the theoretical advantage of being less invasive. Despite this, outcomes have been mixed with reported perioperative mortality rates of 0% and 34% and permanent paraplegia rates of 0% to 13% in most major series. The reported outcomes, as well as the variation between centers, highlight the importance of patient selection in undertaking hybrid repair. In practice, the best outcomes are achieved in patients who have high-risk anatomy, rather than high-risk comorbidities.
Arterial Stiffness Alterations and Inflammatory Response Following Endovascular Aortic Repair
Authors: Moulakakis Konstantinos , Mylonas Spyridon , Kakisis John , Kadoglou Nikolaos , Papadakis Ioannis , Sfyroeras George , Antonopoulos Constantine , Mantas George , Ikonomidis Ignatios , Liapis Christos
Published: February 2019

Based on a Presentation at the 2013 VEITH Symposium, November 19–23, 2013 (New York, NY, USA)

Endovascular abdominal aortic aneurysm repair (EVAR) and thoracic aortic aneurysm repair (TEVAR) have been widely incorporated into clinical practice. However, changes in arterial stiffness and post-implantation syndrome after aortic endografting remain important issues under investigation. The aneurysm sac wall motion after successful EVAR and TEVAR reflects complex interactions between all the components of the excluded aneurysm, including true compliance of the aneurysm wall itself, intra-aneurysm sac pressure, remodeling of the thrombus, and mechanical characteristics of the endograft. Experimental and clinical studies have shown that aortic endografting results in increased arterial stiffness in animal models. It can be assumed that the alterations of aortic mechanical properties can have a direct impact on heart output. The long-term impact of these mechanical changes on cardiovascular outcomes and the potential effects of different endografts on hemodynamics are important issues under investigation. Post-implantation syndrome (PIS) is a systemic inflammatory response frequently observed after endovascular treatment of aortic pathologies. The main features of PIS include fever, leukocytosis, elevated C-reactive protein levels, and coagulation disturbances. Endograft design appears to influence this inflammatory response following aortic endografting; woven polyester endografts have been shown to be associated with greater inflammatory response compared to PTFE stent grafts. The purpose of this paper is to review the literature to elucidate arterial stiffness alterations and inflammatory response after EVAR and TEVAR and the impact of endograft design on aortic stiffness and the post-inflammatory response.
Long-Term Survival After Composite Mechanical Aortic Root Replacement
Authors: Al-Ebrahim Khaled , Jabbad Husain , Alqari Ahmad
Published: February 2019

This report describes the long-term follow-up of the repair of a giant ascending aneurysm using a composite graft with a mechanical valve.
Multi-Velocity Encoding Four-Dimensional Flow Magnetic Resonance Imaging in the Assessment of Chronic Aortic Dissection
Authors: Sherrah Andrew , Callaghan Fraser , Puranik Rajesh , Jeremy Richmond , Bannon Paul , Vallely Michael , Grieve Stuart
Published: February 2019

Background:
Chronic descending thoracic aortic dissection (CDTAD) following surgical repair of ascending aortic dissection requires long-term imaging surveillance. We investigated four-dimensional (4D)-flow magnetic resonance imaging (MRI) with a novel multi-velocity encoding (multi-VENC) technique as an emerging clinical method enabling the dynamic quantification of blood volume and velocity throughout the cardiac cycle.

Methods:
Patients with CDTAD (n = 10; mean age, 55.1 years; standard deviation (SD) 10.8) and healthy volunteers (n = 9; mean age, 37.1 years; SD 11.4; p < 0.01) underwent 3T MRI, and standard views and 4D-flow data were obtained. Flow measurements were made in selected regions of interest within the ascending and descending thoracic aorta.

Results:
The overall flow profile at peak systole was reduced in the false lumen (FL) compared with the true lumen (TL) and normal aortas (p < 0.05 for velocity < 0.4 m/s). Peak systolic flow rate per aortic lumen area (mL/s/cm2) was lower in the FL than in the TL (p < 0.05), and both rates were lower than that of control aortas (p < 0.05). Blood flow reversal was higher in the FL than in the TL throughout the descending aorta in CDTAD patients (p < 0.05). A derived pulsatility index was elevated in the TL compared with that in the FL in CDTAD patients. Generated pathline images demonstrated flow patterns in detail, including sites of communication between the true and FL.

Conclusions:
4D-flow MRI revealed FL blood flow and reduced blood flow velocity and flow rate in the TL of CDTAD patients compared with normal aortas of healthy participants. Thus, multi-VENC 4D-flow MRI could serve as an adjunct in the long-term assessment of CDTAD following surgical repair of ascending aortic dissection.
Too Cold to Clot? Does Intraoperative Hypothermia Contribute to Bleeding After Aortic Surgery?
Authors: Stein Louis , Rubinfeld Gregory , Balsam Leora , Ursomanno Patricia , DeAnda Abe
Published: February 2019

Background:
We determined the impact of intraoperative hypothermia on postoperative bleeding after thoracic aortic surgery.

Methods:
We retrospectively analyzed 98 consecutive patients who underwent aortic surgery with deep hypothermic circulatory arrest between 2010 and 2014. We evaluated lowest temperature, absolute decrease in temperature, and rewarming rate. Univariate and multivariate regression were used to determine relationships between temperature, clinical characteristics, and measures of postoperative bleeding.

Results:
The mean age of patients was 60.5 ± 15.1 years, with 64.3% male and 60% Caucasian. The lowest temperatures recorded were 13.5 ± 4.6°C at the bypass circuit. Change in hematocrit was associated with ethnicity, preoperative hematocrit, and rewarming rate. Chest tube output was associated with body mass index, preoperative platelet count, prior cardiac surgery, cardiopulmonary bypass (CPB) duration, intraoperative blood product transfusion, lowest surface temperature, and change in surface temperature. Postoperative packed red blood cell transfusion was associated with ejection fraction, chronic obstructive pulmonary disease (COPD), platelet count, partial thromboplastin time, CPB duration, and lowest blood temperature. Fresh frozen plasma transfusion correlated with COPD, CPB duration, and final blood temperature. Platelet transfusion correlated with body mass index and preoperative platelet count. Unplanned reoperation for bleeding was associated with final temperature and change in temperature.

Conclusion:
We found no consistent associations between intraoperative temperature and indicators of bleeding. Intraoperative cooling strategies should be based on optimal end-organ protection rather than fear of postoperative bleeding; rewarming strategies may ameliorate the risk of coagulopathy.
Persistent Buttock Claudication after Endovascular Abdominal Aortic Aneurysm Repair
Authors: Robaldo Alessandro , Pagliari Stefano , Piaggio Filippo , Colotto Patrizio
Published: February 2019

We describe the successful surgical treatment of a 71-year-old man affected by right buttock claudication after a right internal iliac artery (IIA) coil embolization as an adjunct to endovascular iliac artery aneurysm repair. Computed tomography angiography revealed extensive aortoiliac calcifications and thrombus in the vessel walls. Despite patency of the contralateral IIA and preservation of right distal collateral flow through ipsilateral hypogastric branches, the symptom was persistent and disabling. The high-risk patient underwent an “open” repair of the infrarenal abdominal aneurysm with removal of the entire stent-graft and concomitant revascularization of the right IIA. Post-operative recovery was uneventful, and the patient remained asymptomatic during a 30-month follow-up. This case underscores the importance of considering all potential solutions, including open surgery, to preserve pelvic inflow after aortoiliac stent grafting, particularly for high-risk patients with vulnerable plaque and higher risk of thrombus embolization.
Single-stage Endovascular Treatment of a Penetrating Aortic Ulcer with a Concomitant “Isolated” Iliac Aneurysm
Authors: Hu Haidi , Guo Jianming , Bai Hualong , Dardik Alan
Published: February 2019

Penetrating aortic ulcer (PAU) is an acute aortic syndrome that can proceed to life-threatening aortic dissection or even aortic rupture. Isolated iliac aneurysms are relatively rare and often asymptomatic due to their deep pelvic location but are frequently associated with high mortality with rupture. We report a case of a 68-year-old man with a symptomatic penetrating ulcer in the descending aorta and an asymptomatic right iliac aneurysm involving the common and internal iliac arteries. The patient was successfully treated by endovascular repair in a single-stage manner using stent grafts in the descending aorta and right common iliac artery after coil embolization of the right internal iliac artery. Follow-up imaging showed complete resolution of the PAU and exclusion of the right iliac aneurysm without endoleak. Aggressive endovascular treatment for a symptomatic PAU with an asymptomatic isolated iliac aneurysm is feasible and allows complete treatment of vascular pathology at a single time.
Diagnostic Utility of Chest Radiography in Predicting Long-Standing Systemic Arterial Hypertension
Authors: Sahin Hakan , Stark Paul
Published: February 2019

Purpose:
To investigate the association between aortic arch width on frontal chest radiography and systemic hypertension.

Methods:
A total of 200 consecutive patients were included. Relationships between aortic arch width measurement on chest radiography and blood pressure measurement were investigated using Student’s
t
-tests and Fisher’s exact tests.

Results:
Twenty-five patients were normotensive (< 130/90 mmHg), and 175 were hypertensive. Using cut-off values, 136 patients had an aortic arch width ≥ 3.5 cm, and 65 had an aortic arch width ≥ 4 cm. We found a significant relationship between aortic arch width and hypertension (p < 0.001) as well between aortic arch width cut-off values of 3.5 cm and 4 cm and hypertension (p < 0.001 and p < 0.005, respectively). An aortic arch width ≥ 3.5 cm was associated with a positive likelihood ratio (LR) of 2.3, negative LR of 0.39, sensitivity of 73, specificity of 68, positive predictive value of 94, negative predictive value of 26.6, pretest odds of 7, posttest odds of 16, and posttest probability of 94%. An aortic arch width ≥ 4 cm was associated with a positive LR of 4.50, negative LR of 0.70, sensitivity of 36, specificity of 92, positive predictive value of 97, negative predictive value of 17, pretest odds of 7, posttest odds of 31.5, and posttest probability of 97%.

Conclusions:
Aortic arch width measurement on chest radiography can be used to predict the presence of long-standing systemic arterial hypertension.
Parental substance misuse and child development: The role of the health visitor in Scotland
Authors: Baird Joanne
Published: February 2019

This article considers parental substance misuse and its impact on child development. Theories of normal child development provide a benchmark to explore the literature on potential outcomes for the developing child where parental substance misuse is a significant factor. The refocused role of the health visitor in Scotland highlights the need to improve outcomes for children at risk through early intervention.
Preventive care and public health
Authors: Oldman Crystal
Published: February 2019

The Long Term Plan for the NHS in England provides a clear focus on the importance of prevention and work that can be undertaken to address inequalities in health, and therefore the work of health visitors, says Crystal Oldman
Optimization of a Whole-Stalk Operating System after Sugarcane Base Cutting
Authors: Xie Luxin , Wang Jun , Cheng Shaoming , Hu Jinbing
Published: February 2019

Abstract.

Leaf stripping and top breaking are the key procedures in whole-stalk sugarcane harvesting. In this study, a whole-stalk operating system after sugarcane base cutting was developed and tested to improve the leafy trash cleaning performance and adaptability of a whole-stalk harvester. A leaf shredding procedure was proposed before leaf stripping, and an anti-float top breaking device was developed for breaking cane tops. The rotational speeds of the leaf shredding (RL), leaf stripping (RS), and top breaking (RT) rollers were regarded as experimental factors, and the leafy trash content (including leaves, leaf sheaths, and tops in this study), top breaking rate, abrasion rate, and non-fracture rate of the middle or bottom parts were selected as indices. Central composite design combined with response surface methodology and comprehensive evaluation method were employed to conduct experiments and explore the interaction effects of factors on indices. The optimal operating parameters were nonlinearly optimized and determined to be RL of 512.9 rpm, RS of 418.8 rpm, and RT of 307.0 rpm. Under these conditions, the predicted values of leafy trash content, top breaking rate, abrasion rate, and non-fracture rate were 4.98%, 88.39%, 5.19%, and 96.21%, respectively. Verification experiments indicated that the observed values were in agreement with the predicted values. Results suggested that the leaf shredding device and anti-float top breaking device developed in this study were effective for improving the leafy trash cleaning performance and adaptability of the whole-stalk operating system, and there was a good potential for performance improvement of whole-stalk sugarcane harvesters. Keywords: Central composite design, Leaf shredding, Leaf stripping, Response surface methodology, Top breaking, Whole-stalk harvester.
Be the opportunity: the heart and soul of corporate social responsibility
Authors: Chin Motthida
Published: February 2019

Companies engage in corporate social responsibility (CSR) as a way to strengthen their business objectives and demonstrate their commitment towards ethical labour practices, safe working conditions and equitable trade. There are many methods to achieve these objectives, and success is often expressed quantitatively. Throughout my twenty years of CSR practice and counsel, however, I have found that while the quantitative success is important for all parties involved to co-operate willingly, to meet objectives, the heart and soul of effective CSR is essentially about relationship building that fuels opportunities for workers, in particular for women and girls in the workplace and in their communities.
Heterogeneous Expression of Proinsulin Processing Enzymes in Beta Cells of Non-diabetic and Type 2 Diabetic Humans
Authors: Teitelman Gladys
Published: February 2019

Although there is evidence indicating transcriptional and functional heterogeneity in human beta cells, it is unclear whether this heterogeneity extends to the expression level of the enzymes that process proinsulin to insulin in beta cells. To address this question, the expression levels of prohormone convertases (PC) 1/3, proprotein convertase 2 (PC2), and carboxypeptidase E (CPE) were determined in immune-stained sections of human pancreas. In non-diabetic donors, the level of proprotein convertase 1/3 (PC1/3) expression varied among beta cells of each islet but the average per islet was similar for all islets of each donor. Although the average PC1/3 expression of all islets examined per sample was unique for each pancreas, donors had similar levels of proinsulin/insulin expression. PC2 expression in beta cells showed less pronounced inter- and intraislet variation while CPE levels were fairly constant. The relationship between PC1/3 and PC2 expression levels was variable among different donors. Type 2 diabetes had an uneven effect on the expression levels of all three enzymes as they decrease only in some islets in a section. These findings suggest the presence of intraislet, but not interislet, variation in the expression of the proinsulin processing enzymes in non-diabetic subjects and a heterogeneous effect of type 2 diabetes on enzyme expression in islets.
The Socio-Demography, Clinical Characteristics and the Prevalence of Cardiovascular Risk Factors Among a Group of Elderly Hypertensive Patients Followed Up at A Tertiary Care Hospital in Sri Lanka.
Authors: Ralapanawa Udaya , Tennakoon Sampath , Jayalath Thilak , Bandara Milinda , Wickramasurendra Noorika , Bandara Ravinath
Published: February 2019

Background Hypertension is one of the most prevalent risk factors for myocardial infarction, strokes, congestive cardiac failure and chronic kidney disease (CKD)and its prevalence is significantly higher inthe elderly population. Objectives To assess the demography, various presentations and the prevalence of risk factors among elderly hypertensive patients followed up in a tertiary care hospital in Sri Lanka. Materials and Methods This was a cross sectional descriptive study involving 250 patients whoseage was 60 years or above onantihypertensives for at least 6 months. Results Approximately 65.2% of the study population was female. The mean age was 70.17.Dizziness and chest pain were the most prevalent symptoms.The mean age at first detection was 58.17 years.Mean SBP and DBP were 128.5mmHg and 81.14mmHg respectively. The prevalence of alcohol consumption and smoking among men were 70.1% and 72.4% respectively. Approximately 54.7% were either overweight or obese.Approximately 81.6% females and 41.4% males had a waist circumference ofmore than therisk level with p-value<0.05. Approximately 36% had diabetes mellitus and 27.6% of the patients had at least one parent and 36.8% had at least one sibling diagnosed with hypertension. Approximately 61.3% of the patients hadadequate levels of physical activity while 31.8% had IHD,11.5% had stroke and 3.8% had CKD. Conclusion Dizziness and chest pain were the most disturbing symptoms while abdominal obesity among females,and alcohol consumption and smoking among males were the major risk factors in elderly hypertensive patients
A Case of Collision Tumor of MALT Lymphoma and Poorly Differentiated Adenocarcinoma Diagnosed Incidentally After Appendectomy for a Clinical Presentation of Acute Appendicitis.
Authors: T Kara , YY Karabulut , AR Bozdoğan , GE Yüksek
Published: February 2019

This report presents a case of collision tumors of low-grade B-cell lymphoma and poorly differentiated adenocarcinoma in the caceum of a 63-year-old woman. Lymphoma was diagnosed incidentally after appendectomy for a clinical presentation of acute appendicitis. Imaging follow-up demonstrated mesenteric lymphadenopathy and liver lesions, and all surgically resected regional mesenteric lymph nodes and liver biopsy were found to be infiltrated by both mucosa-associated lymphoid tissue (MALT) lymphoma and adenocarcinoma. Systemic chemotherapy was administered for advanced colonic adenocarcinoma with liver metastases. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectal region is rare, and this is a previously unreported case of a patient that was diagnosed during management of acute appendicitis.
Estudio del comportamiento mecánico de morteros modificados con fibras de aserrín bajo esfuerzos de compresión
Authors: Ortega Sánchez Andrés David , Gil Harveth
Published: February 2019

En este artículo, se presenta un estudio sobre el comportamiento mecánico de morteros modificados con fibras de aserrín bajo cargas de compresión. Se estimó la densidad, resistencia a la compresión, y el módulo de elasticidad dinámico de morteros modificados con 0, 0,5, 1 y 3% en peso de fibra de aserrín. Los compuestos fueron evaluados luego de 7, 30 y 90 días de curado. Además, se utilizó microscopia electrónica de barrido (SEM) y espectroscopía de rayos X de energía dispersa (EDX) para caracterizar la morfología y encontrar la composición elemental tanto de las fibras como de la matriz de cemento. Los resultados muestran que a mayor porcentaje de aserrín, la resistencia, el módulo de elasticidad y la densidad disminuyen. Se sugiere utilizar hasta 1% de fibra de aserrín en morteros para evitar una reducción importante en las propiedades mecánicas de los morteros.
Fabricación y caracterización de nanopartículas de plata con potencial uso en el tratamiento del cáncer de piel
Authors: Gallo Ramírez Juan Pablo , Ossa Orozco Claudia Patricia
Published: February 2019

El cáncer de piel tipo carcinoma es la patología de mayor frecuencia epidemiológica a nivel mundial. Sus tratamientos convencionales se clasifican según el tipo de cáncer de piel que presenta el paciente y la ubicación del mismo, para su tratamiento se usan procedimientos como la escisión con evaluación de márgenes, radioterapia, curetaje y electro disección, criocirugía, cirugía micrográfica de Mohs, terapia fotodinámica, el 5-fluorouracilo tópico, la terapia con Imiquimod tópico y el láser con dióxido de carbono. A pesar del abanico de técnicas terapéuticas con las que se cuenta, estas terapias generalmente se acompañan de efectos secundarios, es por esto que cobra interés el estudio de nuevas alternativas basadas en ingeniería de tejidos que potencialmente pueden aumentar la efectividad de los resultados anticancerígenos y disminuir la aparición de efectos adversos. Dentro de las técnicas de nanomedicina usadas en cáncer, se tiene que las nanopartículas (NPs), que son biocompatibles y han mostrado efectividad en modelos animales frente a la muerte de células cancerígenas y a la disminución del tamaño de tumores; ya que al absorber fuertemente la radiación cercana al infrarrojo actúan como fuentes de hipertermia local. Con el fin de aumentar los efectos biológicos de las NPs, se puede utilizar la biofuncionalización o activación superficial para asegurar el anclaje de los surfactantes, proteínas y factores tisulares necesarios. En el presente proyecto se obtuvo nanopartículas de plata de tamaño nanométrico, por medio del método de reducción química, en el cual se le modificaron varios parámetros para estandarizar el tamaño de las nanopartículas, punto clave en el tratamiento del cáncer, luego del método de síntesis se hizo un proceso adicional de biofuncionalización mediante el polímero polietilenglicol (PEG) para mejorar las propiedades de anclaje y biocompatibilidad de las nanopartículas. Para la caracterización de las nanopartículas se procedió con técnicas de microscopia electrónica de transmisión; además de espectrofotometría UV-Vis y un ensayo biológico para determinar la viabilidad y citotoxicidad de las nanopartículas. Se concluyó que con el procedimiento implementado se puede sintetizar nanopartículas de plata para un potencial uso en el tratamiento de cáncer de piel.
Bloque de suelo estabilizado en pequeño formato y tecnología de colocación en obra en vivienda de interés social
Authors: Bailón Abad Emperatriz Isabel , Espinosa Guaricela Romel Iván , Acevedo Catá Jorge Bernardo
Published: February 2019

La Universidad Nacional de Loja, ubicada en la frontera sur de Ecuador, investigó sobre la fabricación de bloque con suelo estabilizado en pequeño formato como una alternativa viable para contribuir en la solución de vivienda de interés social. La caracterización físico-mecánica del suelo determinó el uso del cemento para su estabilización; y, el diseño experimental se basó en el modelo multitabla en un hexágono con la manipulación de dos variables: cemento y agua. Los mejores resultados obtuvieron las mezclas con 13 y 9,75 % de cemento y 25 y 22 % de agua respectivamente, con la resistencia a la compresión de 7,78 y 4,66 MPa y el coeficiente de ablandamiento superior a 0,5 que garantizan la resistencia a la humedad. Para confirmar el beneficio social del material desarrollado en laboratorio y su comportamiento en el proceso de colocación en obra, se construyó una vivienda prototipo en la parroquia rural de Chuquiribamba, bajo la modalidad de autoconstrucción para lo cual se cumplió con las fases de: i) Diseño; ii) Producción y iii) Construcción, proceso que permitió un total involucramiento de la familia beneficiaria y de la comunidad.
Originality and authenticity of textiles artefacts in house-museums
Authors: Neira-García Luz
Published: February 2019

This article is a result of the Project for the Museographic Renewal of the Rui Barbosa House Museum, in Rio de Janeiro. This approach discusses the introduction of non-original textiles in the museum, since previous research has demonstrated that its environment is partially featureless. From the theoretical point of view, the idea of renewal is supported by the assumption that decorative textiles are necessary to build the narrative in the museum. From this perspective, some reflections are presented here about the originality versus non-originality of the textile typologies inside historical houses.
IMPLEMENTASI PROGRAM BANTUAN SOSIAL PEMUGARAN RUMAH TIDAK LAYAK HUNI (RTLH) DI DESA NGOTET KAB. REMBANG TAHUN 2017
Authors: Dewi Natalia Kusuma , Anggraeni Melly , Dwimawanti Ida Hayu
Published: February 2019

Kemiskinan diartikan sebagai kondisi ketidakmampuan pendapatan dalam mencukupi kebutuhan pokok sehingga kurang mampu untuk menjamin kelangsungan hidup (Suryawati, 2004: 122). Menurut Badan Pusat Statistik Republik Indonesia, Provinsi Jawa Tengah menempati posisi dua puluh satu dari tiga puluh empat provinsi dengan jumlah penduduk miskin sebesar 3,90 juta penduduk atau sebesar 11,32%. Dengan kondisi tersebut, saat ini terdapat lima belas kabupaten di wilayah Provinsi Jawa Tengah yang berada di bawah garis kemiskinan (Zona Merah) salah satunya adalah Kabupaten Rembang dengan jumlah penduduk miskin pada tahun 2017 sebesar 115,19 ribu atau sebesar 18,35% dari seluruh jumlah penduduk. Tingginya persentase penduduk miskin yang ada di Kabupaten Rembang tersebut mencerminkan masih banyaknya rumah penduduk yang masuk dalam kategori tidak layak huni. Oleh sebab itu, Pemerintah Kabupaten Rembang pada tahun 2017 mulai melaksanakan Program Bantuan Sosial Pemugaran Rumah Tidak Layak Huni (RTLH) bagi penduduk miskin. Program tersebut salah satunya dilaksanakan di Desa Ngotet Kecamatan Rembang Kabupaten Rembang. Namun dalam pelaksanaanya, masih dinilai kurang tepat sasaran dikarenakan terdapat beberapa kriteria yang tidak dilaksanakan dalam menentukan masyarakat atau kelompok masyarakat yang berhak menerima bantuan sosial. Hasil penelitian menggunakan teori implementasi George C. Edwards III dengan fokus pada internal organisasi, terdapat beberapa indikator yang masih harus diperbaiki yaitu komunikasi yang berfokus pada konsistensi pelaksanaan; sumber daya baik dari sisi manusia dan anggaran; disposisi yaitu pengangkatan birokrasi dan insentif. Adapun yang sudah berjalan baik yaitu struktur birokrasi pada sisi mekanisme dan struktur birokrasi di Dinas Perumahan Dan Kawasan Permukiman Kabupaten Rembang.
IMPLEMENTASI PROGRAM PENGUATAN PENDIDIKAN KARAKTER (PPK) DI SDN MANGKANG WETAN 02 KOTA SEMARANG
Authors: Anggraeni Rise Aditya , Soedjono Soedjono
Published: February 2019

Character Education Strengthening Program is an educational movement under the responsibility of the education unit to strengthen the character of students through harmonization of the process of heart, taste, thought processing, and sports with involvement and cooperation between education units, families and communities as part of the National Movement Mental Revolution (GNRM). The purpose of this study was to determine the implementation of Character Education Strengthening in Mangkang Wetan 02 Elementary School Semarang City. This study uses a qualitative method, meaning that the main instrument in the study is the researcher himself. Data sources used include primary data sources and secondary data. The results showed that the implementation of Character Education Strengthening in Mangkang Wetan 02 Elementary School Semarang City was quite successful this can be seen from the level of decline in student delinquency but still needs improvement in the phenomenon of the implementation of school-based character education.
IMPLEMENTASI KEBIJAKAN INPASSING JABATAN GURU BUKAN PNS SMP SWASTA KABUPATEN KENDAL
Authors: Sutadi Sutadi
Published: February 2019

One of the government's efforts in improving the quality of teachers is to implement the policy of determining the inpassing of functional positions of non-civil servant teachers and credit figures. According to Permendikbud number 47 of 2007 renewed Permendiknas no. 22 Year 2010 Inpassing Non Civil Servant Teachers (GBPNS) is the process of adjusting the rank of Non-Civil Servant Teachers to the rank of Master Civil Servant. Permendikbud Number 28 of 2014 renewed Permendikbud Number 12 of 2016 on the granting of equal positions and rank for non-civil servant teachers. Implementation of Inpassing Teacher Program Policy Non PNS SMP Kendal private sector concluded: a) All teachers who are certified educators are able to make a proposal document inpassing the positions of teachers instead of civil servants; b) All teachers remain a certified foundation of educators proposing SK inpassing; c) Only 10% of the proposals can be issued inpassing decree from the Ministry of Education and Culture. The results of research on the factors that inhibit the implementation of policy inpassing the position of junior high school teachers rather than civil servants in Kendal District: a) Communication Factor, the absence of communication between teacher or school with Ministry of Education and Culture related to proposal of inpassing of non-civil servant teacher position become one of the point that hinder the implementation of program; b) Factors Resources, lack of human resources administrative staff in private schools in this case associated with the fulfillment of standards of educational personnel to be one obstacle policy implementation; c) Disposition Factors, Understanding teachers, administrative staff, principals and officials of the District Education and Culture District of Kendal is a good factor driving the implementation of inpassing program. The conclusion of the policy implementation of inpassing of junior high school teachers rather than civil servants in private schools in Kendal District has not been successful.
LAPOR HENDI : JEMBATAN PENGADUAN YANG SETENGAH HATI
Authors: Dzakiyati Fiki , Nugroho Rosihan Widi , Warsono Hadi
Published: February 2019

Lapor Hendi adalah layanan publik berbasis online untuk menyampaikan pengaduan, menyampaikan aspirasi dan berkomunikasi langsung dengan Pemkot Semarang. Inovasi ini menjadi sarana perbaikan layanan publik melalui peran aktif masyarakat dalam melakukan pengawasan.  Penelitian ini bertujuan untuk mengevaluasi pengelolaan pelayanan pengaduan Lapor Hendi serta faktor penghambat dalam layanan Lapor Hendi. Menggunakan metode deskriptif kualitatif dengan studi kasus, pengambilan data melalui studi pustaka dan wawancara. Penelitian ini menggunakan teori William Dunn, 6 faktor dalam melalkukan evaluasi : efektivitas, efisiensi, kecukupan, perataan, responsivitas dan ketepatan serta faktor penghambat dalam pelaksanaan kebijakan. Dalam kajian ditemukan ada 2 faktor utama yang menghambat Lapor Hendi yaitu Sumbar Daya Manusia (SDM) dan Teknologi. Untuk meningkatkan penyelesaikan pengaduan diperlukan SOP sebagai panduan layanan, bukti bahwa pengaduan telah diselesaikan dan kontak penanggung jawab jika masyarakat melakukan konfirmasi terhadap pengaduan.
FORMULASI KEBIJAKAN PERLINDUNGAN LAHAN PERTANIAN PANGAN BERKELANJUTAN DI KABUPATEN KARAWANG
Authors: Amalina Amalina , Binasasi Susilo Diliwanto , Purnaweni Hartuti
Published: February 2019

Penelitian ini dimaksudkan untuk menganalisis Formulasi Kebijakan Perlindungan Lahan Pertanian Pangan Berkelanjutan Di Kabupaten Karawang. Adapun permasalahan di dalam penelitian ini adalah Bagaimanakah Proses Perumusan Kebijakan Perlindungan Lahan Pertanian Berkelanjutan sebagai upaya pengendalian alih fungsi lahan pertanian ke non pertanian. Untuk menjawab permasalahan tersebut maka ditunjang dengan berbagai macam teori dari para ahli yang mempunyai relevansi dengan variabel penelitian. Metode yang digunakan untuk mengumpulkan data yakni observasi dan wawancara dengan menggunakan teknik analisa data deskriptif kualitatif. Setelah peneliti menampilkan data empirik yang di temui di lokasi penelitian.Hasil penilitian di Kabupaten Karawang dalam perumusan Kebijakan Perlindungan Lahan Pertanian Pangan Berkelanjutan yakni: Proses Perumusan Kebijakan Perlindungan Lahan Pertanian Di Kabupaten Karawang diawali dengan perumusan masalah terkait dengan alih fungsi lahan dan tumbuh suburnya industri-industri di lahan 19 ribu Ha, dan pengurangan lahan pertanian di tahun 2015-2017 yakni 625 Ha. oleh sebab itu pemerintah kabupaten karawang menggunakan pendekatan kebutuhan lahan pertanian dan citra satelit untuk mengetahui luasan pertanian yang ada dan menjaga kabupaten karawang tetap eksis sebagai lumbung padi nasional. Dan Pemerintah Kabupaten Karawang memilih alternatif kebijakan terbaik kemudian dimasukan dalam Draf Naskah Akademik terkait Perlindungan Lahan Pertanian Pangan Berkelanjutan yang nantinya akan menjadi draf Peraturan Daerah No 1 Tahun 2018. Alternatif kebijakan perlidungan lahan pertanian pangan berkelanjutan ini juga mengatur tentang insentif bagi petani yaitu adanya subsidi untuk bibit, obat-obatan pertanian, dan alat-alat penunjang pertanian hal ini agar para petani tidak mengalih fungsi lahan pertanian, tetapi 87,5 ribu Ha yang sudah dikunci sebagai zona hijau dan dengan adanya mapping memudahakan bangsa ini dalam mengetahui secara pasti berapa luas lahan pertanian untuk ketahanan pangan.
PENGARUH DAYA TARIK DAN WORD-OF-MOUTH TERHADAP KUNJUNGAN ULANG MELALUI KEPUASAN
Authors: Parastiwi Fitriandini Dwi , Farida Naili
Published: February 2019

Tourism in Indonesia has been growing rapidly. Ketep Pass is one of the natural attractions in Magelang, Regency Central Java in which the number of visits during 2011 to 2015 hasbeen fluctuating. So that the goverment expect to increase visits to attractions Ketep Pass with satisfaction gained from seeing the sights and the positive impact (WOM). The purpose of this study was to identity the effect of attraction and word-of-mouth through satisfaction to re-visit the sights Ketep pass. This type of research is explanatory research, with data collection through questionnaires and interviews. The sampling technique used purposive sampling technique. The Sample was taken from 100 adult visitor respondents who have travelled to Ketep Pass. This study used quantitative analysis techniques. Quantitative analysis using validity, reliability test, the coefficient of correlation, simple and multiple regression analysis, the coefficient of determination, significance test (t test) in one direction, and Sobel test. The results of this research shown that there is a positive effect of natural attractions and word-of-mouth significantly on satisfaction, and satisfaction has a positive effect on return visits. Based on the analysis of Sobel test, known that the variable of natural attractions and word-of-mouth significant effect on satisfaction. Further variables significantly influence the satisfaction of repeat visits. Based on these results it is recommended to increase the repair and maintained the facilities to the tourist attractions as well as add a cultural event which could be an attraction for visitors to visit a tourist attraction Ketep Pass
PENGARUH KETIDAKAMANAN KERJA, KETERLIBATAN KARYAWAN DAN DUKUNGAN ORGANISASI TERHADAP KINERJA KARYAWAN DENGAN KOMITMEN ORGANISASIONAL SEBAGAI VARIABEL INTERVENING PADA KARYAWAN BAGIAN PRODUKSI BULU MATA PALSU PT. COSMOPROF INDOKARYA DI KABUPATEN BANJARNEGARA
Authors: Pawestri Tyasih Sukma , Pradhanawati Ari
Published: February 2019

The performance of employees the production of eyelashes PT. Cosmoprof Indokarya shown at an average of the results of each employee in the years 2013-2015 tends to fluctuate. The target of production  is set by the company is 1.56 million pairs of eyelashes, but only about 1.4 million pairs of eyelashes can  be produced. To deal with the problem is to determine what factors are causing the employee's performance did not reach the target. The high levels of stress and perceived environmental changes employees will create a sense of  insecurity that can affect the performance degradation. Lack of organizational support received by employees will affect their performance. When employees are participating in the work and do not have a strong desire to survive in the organization will decrease the performance of the employee. This is also shown by the employee turnover rate of 20% by year. This study aims to identify and analyze the effects of job insecurity, employee engagement, organizational support and organizational commitment to employee performance and organizational commitment partially as an  intervening variable. Researchers ask 10 (ten)  hypothesis in this study. This type of research is a quantitative research study classification based on objective being explanatory, where statistics were used to analyze the sample data and results will be generalizable to populations where samples were taken. The population in this study were all employees of  the production PT.Cosmoprof  Indokarya as many as 941 employees and the number of samples 91 employees. Data were analyzed using SEM-PLS and use data analysis tools SmartPLS 3.0. The data analyzed comes from distributing questionnaires to employees. Results of testing the coefficient of SEM analysis showed that: (H1) is rejected; (H2) is received; (H3) is received; (H4) is received; (H5) is received; (H6) was rejected; (H7) is received; (H8) is rejected; (H9) was rejected; (H10) is rejected. The results of the study explains there are some weak indicators of each variable job insecurity, employee engagement, organizational support, organizational commitment, and employee performance. It is recommended that companies to review, evaluation, and give motivation and training on employees in order to improve their capabilities.
Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring
Authors: Kittel Maximilian , Findeisen Peter , Ghebremedhin Beniam , Miethke Thomas , Grundt Alexander , Ahmad-Nejad Parviz , Neumaier Michael
Published: February 2019

Background

The increasing number of multi-drug resistant (MDR) bacteria provides enormous challenges for choosing an appropriate antibiotic therapy in the early phase of sepsis. While bacterial identification has been greatly accelerated by the introduction of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), the antibiotic susceptibility testing (AST) remains time-consuming. Here, we present a rapid susceptibility testing method for testing Gram-negative bacteria, exemplarily validated for Escherichia coli and Klebsiella spp.

Methods

Gram-negative isolates (E. coli and Klebsiella spp.) were either taken as single colonies from agar plates (n=136) or directly extracted and identified from positive blood cultures (n=42) using MALDI-TOF MS. Bacteria were incubated in glucose-supplemented Luria broths (LBs) each containing one antibiotic (ceftazidime, piperacillin, imipenem and ciprofloxacin), routinely used to classify Gram-negative bacteria in Germany. To determine susceptibility the dynamics of glucose utilization in bacterial suspensions were quantitatively measured in the presence or absence of antibiotics designated liquid-AST (L-AST).

Results

The L-AST can be run on clinical-chemistry analyzers and integrated into laboratory routines. It yields critical resistance information within 90–150 min downstream of a MS-based identification. The results showed a high concordance with routine susceptibility testing, with less than 1% very major errors (VME) and 3.51% major errors (ME) for 178 assessed isolates. Analysis of turnaround time (TAT) for 42 clinical samples indicated that L-AST results could be obtained 34 h earlier than the routine results.

Conclusions

As exemplified for E. coli and Klebsiella spp., L-AST provides substantial acceleration of susceptibility testing following MALDI-TOF MS identification. The assay is a simple and low-cost method that can be integrated into clinical laboratory to allow for 24/7 AST. This approach could improve antibiotic therapy.
The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants
Authors: Ząbczyk Michał , Kopytek Magdalena , Natorska Joanna , Undas Anetta
Published: February 2019

Background

Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients.

Methods

We assessed 75 venous thromboembolism patients aged 44.5±14.6 years. Blood samples were collected 2–28 h since intake of DOACs, including 50 patients on rivaroxaban, 20 on dabigatran and five on apixaban. LA testing was performed at baseline and after DOAC-Stop treatment. Positive LA was defined as the normalized (patient/standard plasma clotting time) LA screening and screening (LA1)/confirmation (LA2) ratios exceeding 1.2.

Results

LA diluted Russell’s viper venom time (dRVVT) normalized screening test revealed abnormal results in 73 (97.3%) and activated partial thromboplastin time (APTT)-LA in 49 (65.3%) patients. In six (8%) patients, antiphospholipid syndrome (APS) was diagnosed. dRVVT LA1/LA2 was abnormal in 35 (50.7%) patients taking DOACs. The APTT ratio was normal in all studied subjects. DOAC-Stop completely removed dabigatran and reduced by 98% rivaroxaban and by 92.3% apixaban concentrations (all p<0.05). After DOAC-Stop screening dRVVT remained prolonged in 34 (49.3%) patients (p<0.001), while dRVVT LA1/LA2 was abnormal in six (8.7%) subjects, with no association with DOAC concentrations at baseline and after DOAC-Stop. The APTT-LA screening test remained prolonged in five (7.2%) patients, while the APTT LA1/LA2 ratio was normal in those subjects. DOAC-Stop did not influence LA testing in APS patients.

Conclusions

Application of DOAC-Stop effectively reduced plasma DOAC concentrations leading to appropriate dRVVT results in up to 97% of VTE patients.
A Multilevel Examination of Entrepreneurial Orientation and Corporate Entrepreneurship: the Joint Impact of Unit-Level Social Capital and Firm-Level Transformational Leadership
Authors: Chang Yi-Ying , Liu Yi Ping , Chang Che-Yuan
Published: February 2019

We examine the relationship between unit-level entrepreneurial orientation (EO) and unit-level corporate entrepreneurship (CE), which has been typically neglected in entrepreneurship research. Building on the conservation of resource theory (COR), we argue that the relationship between unit-level EO and unit-level CE will be stronger when unit-level social capital is higher. Further, we posit that unit-level social capital becomes more effective when firm-level leaders are viewed as less (and not more) transformational by unit members. Data were collected from 186 managers, 372 employees, and 62 senior managers from 93 units of 31 firms. We find that unit-level EO is positively related to unit-level CE and this relationship strengthens when unit-level social capital is high. This moderating effect of social capital is itself moderated by firm-level transformational leadership, and strengthens as firm-level transformational leadership behaviors decrease (supporting “dark side” views of transformational leadership). Implications of our findings for organizational entrepreneurship research and practice are discussed.
Cellulolytic activity of brown-rot Antrodia sinuosa at the initial stage of cellulose degradation
Authors: Sugano Junko , Linnakoski Riikka , Huhtinen Seppo , Pappinen Ari , Niemelä Pekka , Asiegbu Fred O.
Published: February 2019

The initial stage of cellulose degradation has been studied via in vitro assays of fungi isolated from rotten wood in a boreal forest. Among the 37 isolates, Antrodia sinuosa appeared to be an effective cellulose degrader and was selected for studying the initial degradation process. In the liquid cultivation with carboxymethylcellulose (CMC), the increase of the mycelial dry weight coincided with the pH decrease of the culture medium from pH 5.7 to 3.9, between the 3rd and 6th cultivation day. At the same time, the cellulolytic activity increased; the CMCase activity increased sharply and the reducing sugars reached their maximum concentration in the culture medium. It seems that the decreasing pH enables the cellulose degradation by A. sinuosa at an early stage of the process. The results of this study may be useful for a more efficient industrial application of biomass by means of brown-rot fungi.
Nm23-H1 inhibits hypoxia induced epithelial-mesenchymal transition and stemness in non-small cell lung cancer cells
Authors: Wu Cun-en , Zhuang Yu-wen , Zhou Jin-yong , Liu Shen-lin , Zou Xi , Wu Jian , Wang Rui-ping , Shu Peng
Published: February 2019

The Nm23 gene has been acknowledged to play a crucial role in lung cancer metastasis inhibitory cascades controlled by multiple factors. Low expression or allelic deletion of nm23-H1 is strongly linked to widespread metastasis and poor differentiation of non-small cell lung cancer (NSCLC). In this study, nm23-H1 was down regulated in epithelial-mesenchymal transition (EMT) and stemness enhancement under cobalt chloride (CoCl2)-induced hypoxia in NSCLC cells. Moreover, knocking down of nm23-H1 by shRNA apparently promoted hypoxia induced EMT and stemness, which was entirely suppressed via over expression of nm23-H1. Mechanistically, the Wnt/β-catenin signaling pathway was found to participate in the nm23-H1-mediated process. Besides, XAV939 prohibited cell EMT and stemness which could be impaired by knocking down of nm23-H1, while stable transfection of nm23-H1 attenuated hypoxia phonotype induced by lithium chloride (LiCl). Generally, our experiment provided evidence that nm23-H1 can reverse hypoxia induced EMT and stemness through the inhibition of the Wnt/β-catenin pathway, which may furnish a deeper perspective into the better treatment or prognosis for NSCLC.