bluuebunny/crossref_metadata_2025 huggingface dataset:
Specific microbiome profile in Takayasu Arteritis (TAK) and Giant Cell Arteritis (GCA).
Authors: DESBOIS Anne-Claire , Ciocan Dragos , David Saadoun , Perlemuter Gabriel , Cacoub Patrice
Published: April 2020

Objectives: There is increasing evidence of a close link between microbiota and inflammatory diseases. Microbiota has never been studied in large vessel vasculitis (LVV). We aimed to analyse the blood microbiome profile of patients with LVV [Takayasu arteritis (TAK) or giant cell arteritis (GCA)] and healthy donors (HD). Methods : We studied blood samples of 13 patients with TAK (20 samples), 9 (11 samples) with GCA and 15 HD. The blood microbiome profile was assessed by sequencing of the 16S rDNA blood bacterial DNA. Linear Discriminant Analysis (LDA) coupled with effect size measurement (LEfSe) was used to analyse the differences in the blood microbiome profile between the groups. Results: Samples of TAK patients showed an increase in the levels of Clostridia, Cytophagia and Deltaproteobacteria and a decrease in Bacilli at the class level as compared to HD (LDA>2, p<0.05). Active compared to inactive TAK patients had significantly lower levels of Staphylococcus. Samples of GCA patients showed an increased abundance of Rhodococcus and an unidentified member of the Cytophagaceae family. Microbiota of TAK compared to GCA patients showed higher levels of Candidatus Aquiluna and Cloacibacterium (LDA>2; p<0.05). Differences in blood microbiome were also associated with a shift of bacterial predicted metabolic functions in TAK compared to HD. Similar results were also found in active compared to inactive TAK patients. In conclusion , TAK patients showed a specific blood microbiome profile as compared to healthy controls and GCA patients. Among TAK patients, significant changes of blood microbiome profile were associated with specific metabolic functions.
Epidemiology analysis of the incidence of severe maternal outcomes between level 2 and 3 hospitals in China’s Hunan province from 2012 to 2018
Authors: zhiyu Liu , Lili Xiong , Aihua Wang , Mengjun Zeng , Yinglan Wu , Donghua Xie , Fanjuan Kong , Hua Wang
Published: April 2020

Background: This facility-based study analyzed the epidemiology and incidence of maternal near-miss (MNM) and mortality by hospital level as part of Hunan province’s efforts to raise the quality of hospital care for women. Methods: We used data for MNM and mortality cases for 2012–2018 from 17 hospitals (12 level 2 facilities, five level 3 facilities) that receive referrals for obstetric complications in Hunan province. Data were drawn from China’s National Maternal Near Miss Surveillance System, and collected using the World Health Organization near-miss tool. We calculated the ratio of severe maternal outcomes (SMO) (i.e., MNM and maternal death [MD] cases), mortality index (MI), and MNM to mortality ratio (MNM:MD), and epidemiological factors, organ dysfunction, and maternal complications stratified by hospital level. Chi-square tests to examine differences between groups and total ratios and 95% CI were calculated. Results: There were 518 SMO cases (489 MNM and 29 MD) among 279407 live births (LBs) and 1299 SMO cases(1262 MNM and 37 MD) among 232386 LBs in level 2 and 3 facilities. The total MNM ratio in level 2 and 3 hospitals was 1.75 (95%CI: 1.60–1.91) and 5.43 (95%CI: 5.14–5.74) per 1000 LBs, respectively. There were differences in SMO cases between level 2 and 3 hospitals in maternal age, education, parity, antenatal visits, and history of cesarean sections. In MNM cases, coagulation dysfunction was the main organ dysfunction (level 2 hospitals: 59.10%; level 3 hospitals: 79.32%), and the main maternal complications were obstetric hemorrhage (level 2 hospitals: 71.98%) and hepatopathy (level 3 hospitals: 69.49%). For MD cases, the main maternal complications were neurologic dysfunction (level 2 hospitals: 41.38%) and coagulation dysfunction (level 3 hospitals: 42.55%). Anemia was the main maternal complication for SMO cases in both level 2 (69.69%) and 3 (68.59%) hospitals. Conclusions: MNM and MD is higher in level 3 hospitals compared with level 2 hospitals. The obstetric emergency capacity of level 3 hospitals is higher than that of level 2 hospitals. Future government policies should consider upgrading the obstetric emergency treatment capacity in level 2 hospitals or to re-distinguish the social functions of different medical institutions.
The value of atherogenic index of plasma in non-obese patients with non-alcoholic fatty liver disease: a secondary analysis based on a cross-sectional study.
Authors: Dong Buyuan , Mao Yuqing , Li Zhengyang , Yu Fujun
Published: April 2020

Background
Atherogenic index of plasma (AIP) is elevated in fatty liver, but its value in non-obese patients with non-alcoholic fatty liver disease (NAFLD) is unclear.
Methods
The present study involved non-obese Chinese and Japanese participants. We used univariate and multivariate logistic regression model to determine risk factors. The performances of risk factors were compared by calculation of the area under the receiver operating characteristic curve.
Results
In the unadjusted model, we observed that odds ratio (OR) for every one standard deviation (SD) increase in AIP was 52.30. In the adjusted model I and model II, the OR for every one SD increase in AIP was 36.57 and 50.84, respectively. The area under the receiver operating characteristic curve for AIP was 0.803 and 0.802 in the development group and in the validation group, respectively. The best cut-off value of AIP in the discrimination between NAFLD and non-NAFLD was 0.005 in the Chinese group and was − 0.220 in the Japanese group, respectively.
Conclusions
Our results indicate that AIP and NAFLD have a positive correlation in Chinese and Japanese populations. AIP is an independent correlative factor of non-obese patients with NAFLD, which can be used as a new indicator of health examination.
The Use of Mobile Phones for the Prevention and Control of Arboviral Diseases: A Scoping Review
Authors: Carrillo Maria Angelica , Kroeger Axel , Sanchez Rocio Cardenas , Monsalve Sonia Diaz , Ranzinger Silvia Runge
Published: April 2020

Background: The rapid expansion of dengue, Zika and chikungunya with large scale outbreaks are an increasing public health concern in many countries. Additionally, the recent coronavirus pandemic urged the need to get connected for fast information transfer and exchange. As response, health programmes have -among other interventions- incorporated digital tools such as mobile phones for supporting the control and prevention of infectious diseases. However, little is known about the benefits of mobile phone technology in terms of input, process and outcome dimensions. The purpose of this scoping review is to analyse the evidence of the use of mobile phones as an intervention tool regarding the performance, acceptance, usability, feasibility, cost and effectiveness in dengue, Zika and chikungunya control programmes. Methods: We conducted a scoping review of studies and reports by systematically searching: i) electronic databases (PubMed, PLOS ONE, PLOS Neglected Tropical Disease, LILACS, WHOLIS, ScienceDirect and Google scholar), ii) grey literature, using Google web and iii) documents in the list of references of the selected papers. Selected studies were categorized using a pre-determined data extraction form. Finally, a narrative summary of the evidence related to general characteristics of available mobile health tools and outcomes was produced. Results: The systematic literature search identified 1289 records, 32 of which met the inclusion criteria. From the reference lists of included articles 4 records were identified coming to a total of 36 studies. The content analysis identified five mobile phone categories: mobile applications (n = 18), short message services (n=7), camera phone (n = 6), mobile phone tracking data (n = 4), and simple mobile communication (n = 1). These devices were used for surveillance, prevention and management. In general, mobile phone-based studies reported good performance, acceptance by users, usability in downloads as well as feasibility of mobile phone under real life conditions and effectiveness in terms of contributing to a reduction of vectors and disease. It can be concluded that there are great opportunities for using mobile phones in the fight against arboviral diseases as well as other epidemic diseases . Further studies particularly on acceptance, cost and effectiveness at scale are recommended.
Thyroid function and thyroglobulin level in iodine deficient children of eastern Nepal
Authors: Kunwar Saroj , Khatiwada Saroj , Gelal Basanta , Thapa Saroj , Shah Gaurishankar , Baral Nirmal , Lamsal Madhab
Published: April 2020

Objective: Both iodine deficiency and excess can negatively impact thyroid function. The present study was conducted to assess iodine nutrition among children and thyroid function in iodine deficient children. Results: A total of 1012 school aged children (6-14 years) from several schools of Udayapur district were enrolled initially for the assessment of urinary iodine concentration (UIC). Blood samples (n=83) were collected from a subgroup of children who had UIC<100 µg/L to measure serum thyroglobulin (Tg), thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4). Serum UIC was measured by ammonium persulfate digestion method and Tg, TSH, fT4 and fT3 were measured by ELISA kits from Diametra Company. The prevalence of insufficient UIC (UIC<100 µg/L) was 11.1% in school children’s of Udayapur district. The median UIC was 236 µg/L. The mean fT3, fT4 and TSH among children with insufficient UIC were 2.55±0.43 pg/mL, 0.96±0.28 ng/dL and 3.60±1.44 mIU/L respectively. The Median Tg was 17.5 ng/mL. Overt hypothyroidism and subclinical hypothyroidism was seen in 6% and 3.6% cases with UIC<100 µg/L respectively.
Cell-free DNA screening for sex chromosomal aneuploidies in 9985 pregnancies: Italian single experience.
Authors: Margiotti Katia , Cesta Anthony , Russo Claudio Dello , Cima Antonella , Barone Maria Antonietta Barone , Viola Antonella , Sparacino Davide , Mesoraca Alvaro , Giorlandino Caludio
Published: April 2020

Objective : Noninvasive prenatal testing (NIPT) using cell-free fetal DNA (cffDNA) has been widely accepted in recent years to detect common fetal autosomal chromosome aneuploidies and sex chromosome aneuploidies (SCAs). In this study, the clinical performance of our fetal DNA testing was investigated by analyzing the sex chromosome aneuploidy aberrations among 9985 pregnancies. The study was a retrospective analysis of collected NIPT data from the Ion S5 Next-Generation Sequencing (NGS) platform obtained from Altamedica Medical Centre of Rome. Results : NIPT analysis of 9985 pregnancies revealed 31 cases with abnormal SCA results (0.31%). Among the 31 positive NIPT cases, 22 women agreed to undergo fetal karyotyping, whereas 9 refused further analyses. Of the 22 women verified by karyotyping analysis, 77.3% (17/22) were confirmed to be true positive SCAs, whereas 22.7% (5/22) were false positive. Among the true positive cases, 53.0% (9/17) were positive for monosomy X, 17.6% (3/17) were positive for 47,XXX aneuploidy, 23.5% (4/17) were positive for 47,XXY aneuploidy, and 5.9% (1/17) were positive for 47,XYY aneuploidy. In conclusion, the present results confirm that NIPT is a potential method for SCA screening, although this technology needs to be further investigated to improve the test performance.
Effects of Endometriosis on Sleep Quality of Women: Does Life Style Factor Make a Difference?
Authors: Youseflu Samaneh , Sadatmahalleh Shahideh Jahanian , Roshanzadeh Ghazall , Mottaghi Azadeh , Kazemnejad Anoshirvan , Moini Ashraf
Published: April 2020

Background

This study aimed to evaluate the impact of lifestyle factors, and sleep quality on endometriosis risk.

Methods

Of the 156 infertile women approached for the study, 78 women had endometriosis and 78 were included in the control group. At first, each participant completed a checklist including questions about demographics, physical activity, reproductive and menstrual status. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Dietary data were collected using a validated 147-item semi-quantitative FFQ.

Results

Irregular menstrual status, menorrhagia, dysmenorrhea, pelvic pain, history of abortion, family history of endometriosis were associated with endometriosis risk (P <0.05). In women with physical activity more than 3 hours per week, high consumption of the dairy product, and fruit endometriosis is less common (P <0.05). The total PSQI score, and the scores for subjective sleep quality, sleep latency, sleep disturbance domains were significantly different between the two groups (P <0.05). In women with endometriosis, poor sleep quality was associated with dysmenorrhea, pelvic pain, dyspareunia, physical activity, and consumption of the dairy product, fruit, and nut (p<0.05).

Conclusion

In endometriosis women, sleep quality was lower than healthy individuals. Lifestyle factors can effect on sleep quality of these patients.
Temporal changes in psychobehavioural responses during the early phase of the COVID-19 pandemic in Malaysia
Authors: Wong Li Ping , Alias Haridah
Published: April 2020

Monitoring public psychological and behavioural responses during the early phase of the coronavirus disease 2019 (COVID-19) outbreak is important for the management of infection prevention and control. This study aims to investigate the temporal trend in preventive measures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, fear, socio-economic impact, perception of susceptibility/severity and anxiety levels during the early phase of the COVID-19 pandemic. Between 25 January and 3 April 2020 a total of 962 survey responses were received. The majority of respondents had good levels of avoidance and protective behaviour. A high perception of severity (76.5%; 95%CI = 73.7–79.2) of SARS-CoV-2 infection was reported but perception of susceptibility was relatively low (30.6%; 95%CI = 27.7–33.6). A sizeable proportion of study participants were greatly impacted by the COVID-19 outbreak, with a total impact score of 9.1 (standard deviation 4.7) from a possible total score of 15, and 72.1% (95%CI = 69.2–75.0) reported moderate to severe anxiety as measured by the State-Trait Anxiety Inventory. Overall, the psychological and behavioural responses were found to increase with progression of the outbreak, however a slightly higher increase was observed for the socio-economic impact. These temporal trends during the early phase of the COVID-19 pandemic provide valuable insights for mitigation strategies to contain the current rapidly escalating outbreak.
Chloroquine, arbidol (umifenovir) or lopinavir/ritonavir as the antiviral monotherapy for COVID-19 patients: a retrospective cohort study
Authors: Huang Hui , Guan Lili , Yang Yuqiong , Grange Jehane Michael Le , Tang Guoyan , Xu Yifan , Yuan Jingjing , Lin Changqing , Xue Mingshan , Zhang Xinlu , Chen Rongchang , Zhou Luqian , Huang Wenjie
Published: April 2020

Background: The severe acute respiratory syndrome coronavirus-2 outbreak was identified in China in December 2019 and spread worldwide, reaching the pandemic levels. However, a specific, effective and proven therapy for the patients with coronavirus disease 2019 (COVID-19) remains elusive. We aim to compare the efficacy and the safety of three antiviral monotherapies (chloroquine phosphate, arbidol (Umifenovir) or lopinavir/ritonavir) in non-severe, hospitalised COVID-19 patients.Methods: We retrospectively analysed the hospitalised, laboratory-confirmed COVID-19 patients, treated with antiviral monotherapies at Huizhou Municipal Central Hospital between Jan 19 and Mar 16, 2020. Demographic and clinical data were extracted from electronic medical records. The primary outcome of the study was the viral shedding interval.Results: Twenty-seven patients with COVID-19 were included in the study with 10 receiving chloroquine phosphate, 11 receiving arbidol and 6 receiving lopinavir/ritonavir. Baseline demographics and clinical data were similar between groups. The median viral shedding interval in the lopinavir/ritonavir group was 13.0 days (95% CI: 12.2-23.8), while significantly shorter in the chloroquine group at 5.0 days (95% CI: 0.4-9.6) (p=0.003). A reduced median interval was also observed in the arbidol group, with 8.0 days (95%CI: 4.9-11.1) (p=0.008). Moreover, the hospitalisation duration was shorter in the chloroquine (9.3 ± 1.8 days, p<0.001) and arbidol groups (11.7 ± 3.7 days, p<0.001), and the hospitalisation costs were significantly reduced in the chloroquine (USD 1327 ± 566, p=0.001) and arbidol groups (USD 1167 ± 434, p<0.001), when compared with the lopinavir/ritonavir group (hospitalisation length and costs: 19.7 ± 4.4 days and USD 3806 ± 2262, respectively). Conclusions: Chloroquine and arbidol could not only shorten the viral shedding interval but also decreased the hospitalisation duration and hospitalisation expenses.Trial registration: The ethics committee of the Huizhou Municipal Central Hospital approved this study, and the trial was registered with www.chictr.org.cn (ChiCTR2000030931).
The method of parameter reassessment for prediction of NCP(2019-nCoV) spread
Authors: Guo Jin-Li , Fu Ya-Zhi
Published: April 2020

This paper proposes a conversion rate prediction method and a parameter reevaluation method based on Logistic curve (S-curve) to predict the spread of NCP (the Novel coronavirus pneumonia). According to the statistical data, we use the conversion rate prediction method to predict the spread of NCP. The prediction accuracy is quite high. By fitting the cumulative number of NCP sufferers with the logistic curve, the average estimation method of the limit number is proposed to predict the spread of NCP and the limit number of sufferers. This paper also assessing the effectiveness of prevention and control measures with the dynamic estimation of the infection probability of NCP. Based on the Markov property, the parameter reevaluation method proposed in this paper avoids over-fitting the theoretical curve and improves the accuracy of prediction. This research idea is not only suitable for Logistic curve regression, but also for other regression prediction problems.
Report of an Iranian COVID-19 Case in a Laparoscopic Cholecystectomy Patient: Case Report and Insights
Authors: vakili sina , Akbari Hamed , Ghahramani Leila , jamalnia sheida
Published: April 2020

Background: The latest outbreak of coronavirus (2019-nCoV), emerging in Wuhan, China, has spread exponentially in 2019.Case presentation: In the present study, we documented a case of COVID-19 in an Iranian patient for laparoscopic cholecystectomy and established the diagnosis, symptoms, and treatments of the case in order to provide non-emergent surgical procedure triage guidelines. Conclusions: This case highlights the importance of good collaboration between doctors and the authorities of public health in Iran, plus the demand for urgent exchange of clinical experience and knowledge with regard to the treatment of this infectious disease.
Social Media and Intangible Cultural Heritage for Digital Marketing Communication: Case of Marrakech Crafts
Authors: Hammou Ichraq , Aboudou Sabrine , Makloul Youssef
Published: April 2020

Morocco is endowed with an intangible cultural heritage of great interest at the global level, to which Moroccan craftsmanship, for which it is widely known internationally, makes a significant contribution. In today's, the notion of heritage is continuously expanding, experiencing an almost unlimited extension. The intangible heritage increasingly occupies a prominent place in the planning of several bodies, whose aim is to raise awareness among nations of the need to protect their cultural diversity and to help them to develop projects for the safeguarding and preservation of this category of heritage. The majority of marketing research has not addressed the issue of the relationship between social media communication and the promotion of intangible cultural heritage in the sense that there is an information deficit in addressing this issue. The concept of social media communication represents for professionals a lever of great importance since it has become indispensable to a good marketing strategy. It constitutes, in the context of research, a real tool for the promotion of intangible cultural heritage and the enhancement of territories. The main objective of this article is to explore the concept of intangible cultural heritage given the great importance it represents and its relationship with social media communication in the Moroccan context, especially in the promotion, transmission and even the safeguarding of this wealth. The study used a multidisciplinary exploratory in the fields of media communication and territorial marketing. Thus, the study focused on the two concepts: intangible cultural heritage and communication through social media, while analysing the nature of their interrelation in general and more specifically the relationship between communication through social media and the promotion of Marrakech handicrafts as part of Morocco's intangible cultural heritage. The results of this empirical study of an exploratory nature, conducted among 14 experts operating in the Moroccan handicrafts sector, demonstrated the existence of a strong relationship between the use of social media communication and the promotion of Moroccan intangible cultural heritage and more specifically the intangible cultural heritage of the city of Marrakech through the development and enhancement of its handicraft products.

Keywords
communication, intangible cultural heritage, Marrakech, Moroccan craftsmanship, social media.
Consumer Behaviour of Seniors on the Cow’s Milk Market in Slovakia: Silver Persuading Techniques
Authors: Krivosikova Alexandra , Rybanska Jana , Nagyova Ludmila , Geci Andrej
Published: April 2020

Seniors are usually perceived as an unattractive segment, mostly due to their limited spending power. In Slovakia, the number of seniors has continuously been increasing. The population has been growing older. In Europe, more than a quarter of the population is expected to be aged 65 years or older by 2050. That is the main reason why we have to understand the consumer behaviour and decision-making processes of senior consumers. The presented paper deals with the consumer behaviour of seniors on the Slovak market of cow’s milk since it is the most commonly consumed type of milk in Slovakia. Opinions of nutrition specialists differ on whether it is beneficial or not for humans to consume milk. However, in general, milk is considered to be an essential component of the diet not only for children but also for adults and especially for seniors because of its high nutrition value. Milk and dairy products should be a daily part of the seniors’ diet. Since older people no longer have the necessary enzyme (lactase) to break down milk sugar (lactose), it is recommended to consume milk products that no longer contain milk sugar, but that lactic acid is produced by fermentation. Sour milk products such as curd, yoghurt or kefir have a beneficial effect on stomach, intestines and also the immune system. Long-term insufficiency of calcium intake causes osteoporosis – a disease that manifests itself in bone loss and structural disorders. It leads to increased fracturing of the bones and thus an increased risk of health complications resulting from there. This study explores senior consumers’ preferences for milk and their decision-making strategies on the market of cow’s milk. The study is oriented primarily on visual cues catching the attention of consumers. Anonymous survey was conducted on a sample of 470 senior respondents (210 males and 260 females) aged 61 – 84. Using selected psychological tools and a short questionnaire it was found out that Slovak seniors prefer traditional motives and bright colours on the milk packaging, they highly prioritise price over quality of milk products and in comparison with young adults, they are loyal to chosen products or brands. Seniors who score higher on the scale of neuroticism personality trait state that the packaging of milk products is significant for their decisions. Seniors with higher emotional stability tend to experiment more on the market of milk.

Keywords
cow’s milk, seniors, consumer behaviour, packaging, persuading techniques.
Digitalization for Human Resource Management
Authors: Rachida Aallali
Published: April 2020

Behaviours, sometimes different expectations as well as mastery and use of IT are new data to be integrated within the framework of an effective human resources policy. In the absence of real intergenerational management that promotes synergy and the emergence of collective intelligence, individual employees develop withdrawal strategies and anticipate their exclusion, which leads them to self-stigmatize. The objective of intergenerational management is to establish a working climate that promotes communication between generations and their well-being. It makes it possible to organize interactions between generations in work situations and define a common operating language so that profiles of the same age and different ages can lead to the implementation of a joint project. In other words, the usefulness of intergenerational management is to reduce tensions and conflicts beyond stereotypes. The article deals with the issue of intergenerational management to understand the sources of disputes between the different generations within Moroccan companies in the banking sector. The main objective of the research is twofold, firstly to determine the source of the intergenerational conflict by referring to a set of theoretical and empirical studies. The latter shows that the conflict between the different generations is closely linked to the systems of human resource management. On the other hand, bringing concrete leads to companies to understand the problem of intergenerational and to adapt their management methods according to the expectations of the different socio-professional categories. To respond to this problem in the Moroccan context, a qualitative empirical study was conducted with managers from three generations: baby boomers, generation X and generation Y and working in four banks. The empirical research has made it possible to understand the expectations of different ages and shows that beyond the intrinsic characteristics of individuals at work, expectations converge, and the organization of action is likely to be the primary source of intergenerational conflicts. Also, the digitization and use of the computer tool by different generations do not present an obstacle to intergenerational cooperation. The present study provided answers to the defined problem. It also made it possible to identify other variables capable of explaining the intergenerational conflict other than those identified in the literature review. It is more particularly the problem of time management and the lack of support systems. As a research perspective, the results of this study will be useful for testing these hypotheses and confirming them, considering the specificities of Moroccan business. Keywords collective intelligence, digitalization, expectation, human resource management, individual competence, intergenerational conflict.
Der Weltbegriff in der neueren kroatischen Philosophie
Authors: Barišić Pavo
Published: April 2020

Uspon i dometi pitanja o svijetu u suvremenoj filozofiji dovode se u ovom članku u svezu sa zalaskom metafizičkoga pitanja o bitku i s nihilističkom krizom uma. Ta kriza logosa manifestirala se, prije svega, u prevladavanju znanstvenoga pozitivizma i prevlasti svjetonazorskih ideologija. U žarištu razmatranja nalaze se filozofske struje druge polovice 20. stoljeća u Hrvatskoj. Prikaz prati u prvom redu političku privlačnost i misaoni utjecaj izazovne teme na oblikovanje pluralističkoga svijeta ideja i demokratski preokret koji je uslijedio. Razmatranje započinje pitanjem kako su filozofska promišljanja o pojmu svijeta odgovarala i poticala otvaranje procesa liberalne demokratizacije u društvu. Istraživanje svijeta pokazalo se dijaloškim i pluriperspektivističkim okvirom u različitim filozofskim strujama. On je dao poticaj i otvorio pristup promišljanju i raspravi o zajedničkim težnjama posve različitim, pa čak i suprotstavljenim teoretskim nazorima i filozofskim strujama.
Sažeti filozofijsko-povijesni prikaz istaknutijih modela zasnivanja svijeta iznosi na vidjelo misaone prinose i odgovarajuće publikacije u tri glavna vala koji su prepoznatljivi od 1953. do 1962., od 1964. do 1984., te naposljetku od 1986. do 1995. Pojmovna postignuća razdijeljena su na pet filozofijskih pravaca: fenomenološko-aksiološko oblikovanje svijeta, fenomenološko-hermeneutičko tumačenje svijeta, praksističko- marksističko zasnivanje svijeta, znanstvenoanalitička konstrukcija svijeta i univerzalističko-integrativna filozofija svijeta. Od predstavnika razmatraju se argumentacije Pavla Vuk-Pavlovića, Vladimira Filipovića, Marije Bride, Franje Zenka, Vanje Sutlića, Danila Pejovića, Ante Pažanina, Branke Brujić, Sulejmana Boste, Željka Pavića, Milana Kangrge, Branka Bošnjaka, Gaje Petrovića, Line Veljaka, Ante Čovića, Zdravka Radmana, Mislava Kukoča, Mislava Ježića i autora ovoga članka. Pobliže razmatranje temeljnih postavaka potvrđuje zaključak da se pojam svijeta može označiti »kao temeljni pojam nove epohe« (Marija Selak, 2013, 188). Pitanje o svijetu tako je stožerna filozofijska tema na kojoj se duhovi susreću i razilaze, okupljaju i raspršuju, vode dijaloge i prepiru; u okviru svijeta misaoni horizont uzmaže se integrirati u svojoj različitosti. To je pitanje potaknulo višestruka promišljanja i mnoge rasprave, koje su bile plodonosne u potrazi za pluralizmom i jasnijom pluriperspektivnošću u razmatranju života i prirode, jednako kao i u političkoj zbiljnosti, tj. u zauzimanju za više slobode, reda i logosa u duhovnom svemiru. Naposljetku, čini se da je pitanje o svijetu zadržalo i danas živahno zanimanje koje može poticati daljnje filozofijske istraživačke misije i pokretati nove misaone avanture u budućnosti.
Os Burocratas de Nível de Rua a Partir dos Modelos de Administração Pública
Authors: Euclydes Fillipe Maciel , Silveira Suely De Fátima Ramos
Published: April 2020

: O presente ensaio visa fomentar o debate em torno das características do burocrata de nível de rua a partir de dois modelos de administração pública dissonantes: A Nova Gestão Pública (NGP) e o Novo Serviço Público (NSP). A NGP tem como objetivo principal a consecução de um Estado mais eficiente, utilizando-se de instrumentos como a privatização de funções públicas substanciais e a reformulação do sistema de funcionalismo público. O NSP, contudo, é uma tentativa de oposição à racionalidade instrumental, origem tanto do modelo burocrático quanto do modelo gerencial, buscando uma administração mais democrática. Ao compartilhar a perspectiva de Lipsky (2010), acreditamos que esse burocrata se estabelece como um centro de controvérsia política – sofrendo pressão de caráter tanto institucional quanto popular – e que este ensaio buscou analisá-lo conforme diferentes paradigmas da administração. Este estudo baseia-se ainda na perspectiva de Meneghetti (2011), o qual observa um ensaio-teórico como um importante instrumento que amplia a interdisciplinaridade, tendo em vista o objeto essencialmente poliédrico a ser trabalhado – o burocrata de nível de rua -, e promove a construção do saber através do debate intersubjetivo entre seus pares.
Determination of the optimal step of installation between the evaporator pipes and the number of condenser units of the system of temperature stabilization of soils HET
Authors: Ishkov Alexey A. , Anikin Gennady V.
Published: April 2020

Interest in developing the resource base of the Arctic and subarctic regions has recently increased thanks to the efforts of the media, oil corporations and the government, however, it must be understood that during the construction on the soils of these regions, in which ice acts as a cementing material, their natural temperature regime is violated. leading to the melting of the ice phase. It is known that when thawing frozen soil it loses its strength properties, as a result of which the foundations of the structures on which they are built are at risk of deformation and destruction.
To solve this problem, special devices have been developed - seasonally acting cooling devices (SOU), which cool the soil in the cold season and "lock up" in the warm. For this reason, these devices are also called "thermal diodes."
In this work, we consider the system of temperature stabilization of soils HET (horizontal naturally acting tubular system) installed at the base of a vertical steel tank (PBC) filled with hot oil-water mixture. A system is considered, in which ammonia acts as a coolant. In addition, the article carried out calculations of various design solutions of the HET system, expressed in variations of such parameters as the length of the evaporator, the number of condensers, and the installation step between the pipes of the evaporator. The work raises the question of justifying the laying step between the pipes of the HET system evaporator and the number of condenser blocks that will be sufficient for the effective functioning of the system, i.e., to maintain the soil in a frozen state. It is shown that for the effective functioning of the system it is not necessary to use a standard paving step equal to 0.5 m, but it can be increased without the risk of losing the bearing capacity of frozen soil. One of the results of the work is the fact that the system is overdetermined by the temperature of stabilization of soils of the HET type at small distances of the laying step relative to the increased distance, which is expressed in a decrease in the number of working days during a calendar year, all other things being equal.
Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies
Authors: Topçu Gülaçtı , Akdemir Atilla , Kolak Ufuk , Öztürk Mehmet , Boğa Mehmet , Bahadori Fatemeh , Çakmar Seda Damla Hatipoğlu
Published: April 2020

Background:

Alzheimer’s Disease (AD) is one of the most prevalent causes of dementia in
the world, and no drugs available that can provide a complete cure. Cholinergic neurons of the cerebral
cortex of AD patients are lost due to increased activity of cholinesterase enzymes.

Objectives:

Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) are the two major classes
of cholinesterases in the mammalian brain. The involvement of oxidative stress in the progression of
AD is known. Thus, the objective of this study is to determine strong ChE inhibitors with anti-oxidant
activity.

Methods:

In this study, 41 abietane diterpenoids have been assayed for antioxidant and anticholinesterase
(both for AChE and BuChE) properties in vitro, which were previously isolated from Salvia
species, and structurally determined by spectroscopic methods, particularly intensive 1D- and 2DNMR
and mass experiments. Molecular modeling studies were performed to rationalize the in vitro
ChE inhibitory activity of several abietane diterpenoids compared with galantamine.

Results:

Thirteen out of the tested 41 abietane diterpenoids exhibited at least 50% inhibition on either
AChE or BuChE. The strongest inhibitory activity was obtained for Bractealine against BuChE
(3.43 μM) and AChE (33.21 μM) while the most selective ligand was found to be Hypargenin E
against BuChE enzyme (6.93 μM). A full correlation was not found between anticholinesterase and
antioxidant activities. The results obtained from molecular modelling studies of Hypargenin E and
Bractealine on AChE and BuChE were found to be in accordance with the in vitro anti-cholinesterase
activity tests.

Conclusion:

Abietane diterpenoids are promising molecules for the treatment of mild-moderate AD.
Overexpression of p62 Induces Autophagy and Promotes Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma Cells through Promoting ERK Signaling Pathway
Authors: Wu Qiong , Xiang Manlin , Wang Kun , Chen Zhen , Long Lu , Tao Ya , Liang Yunlai , Yan Yahui , Xiao Zhiqiang , Qiu Shiyang , Yi Bin
Published: April 2020

Background:

Increasing evidence has shown that p62 plays an important role in tumorigenesis.
However, relatively little is known about the association between p62 and tumor invasion
and metastasis; in addition, its role in NPC (nasopharyngeal carcinoma, NPC) has been rarely investigated.

Objective:

To investigate the effect of p62 on tumorigenesis and metastasis in nasopharyngeal carcinoma.

Methods:

Western blotting, immunofluorescent staining and immunohistochemistry were used to
evaluate p62 protein expression. Subsequently, cell viability, colony formation, migration, invasion
and autophagy assays were performed. anti-p62 autoantibodies in sera were detected by ELISA.
These data were correlated with clinicopathological parameters.

Results:

We confirmed that p62 was significantly up-regulated in NPC tissues. Furthermore, high
expression of p62 was observed in NPC cell lines, and especially in the highly metastatic 5-8F cells.
In vitro, down-regulation of p62 inhibited proliferation, clone forming ability, autophagy, migration,
and invasion in 5-8F cells, whereas p62 overexpression resulted in the opposite effects in 6-10B
cells. Moreover, we confirmed that p62 promotes NPC cell proliferation, migration, and invasion by
activating ERK (extracellular signal-regulated kinase, ERK). Clinical analysis indicated that high
p62 expression correlates with lymph node and distant metastasis (P<0.05). Serum anti-p62 autoantibodies
were increased in NPC patients and levels were associated with metastasis.

Conclusion :

Our data establish p62 targeting ERK as potential determinant in the NPC, which supplies
a new pathway to treat NPC. Furthermore, p62 is a potential biomarker which might be closely
related to the tumorigenesis and metastasis in NPC.
The Evolving AML Genomic Landscape: Therapeutic Implications
Authors: Horibata Sachi , Alyateem George , DeStefano Christin B. , Gottesman Michael M.
Published: April 2020

Improved understanding of the genomic and molecular landscape of acute myeloid leukemia
(AML) has resulted in a significant evolution of our understanding of AML biology and allows
refined prognostication for those receiving standard combination chemotherapy induction. This
dramatic increase in knowledge preceded, and was somewhat responsible for, at least some of eight
new FDA drug approvals for AML. This review discusses the impact of genomics on clinical care of
AML patients and highlights newly approved FDA drugs. Despite these recent clinical advances,
however, the outcome for most patients diagnosed with AML remains dire. Thus, we describe here
some of the challenges identified with treating AML including off-target toxicity, drug transporters,
clonal heterogeneity, and adaptive resistance, and some of the most promising opportunities for improved
therapy.
The Effect of Bitter Melon (Momordica charantia) Extract on the Uptake of 99mTc Labeled Paclitaxel: In Vitro Monitoring in Breast Cancer Cells
Authors: Kilcar Ayfer Y. , Yildiz Onur , Dogan Tansu , Sulu Ezgi , Takan Gokhan , Muftuler Fazilet Z.B.
Published: April 2020

Background:

Bitter Melon Extract (BME) is widely used for the treatment of various diseases
worldwide due to its rich phytochemical and antioxidant content. The well-known anti-cancer drug Paclitaxel
(PAC) plays a major role in the treatment of various cancer types such as ovarian, breast, and lung cancer.
Technetium-99m (99mTc) radiolabeled paclitaxel is emerging as an imaging probe for breast cancer in vivo. 99mTc
labeled compounds have been attracting more scientific attention since the achievement of earlier researches in
Nuclear Medicine. People consume several types of diets of plant origin without knowing the interaction with
radiolabeled compounds or radiopharmaceuticals.

Objectives:

In the current study, we aimed to monitor the potential effects of the BME on the uptake of 99mTc
labeled Paclitaxel (99mTc-PAC) against MCF-7 (ER+) and MDA-MB-231 (ER-) cell lines by using in vitro
methods.

Methods:

BME was obtained by the extraction of BM seeds by 80% ethanol. PAC was labeled with 99mTc by
stannous chloride (SnCl2) as a reducing agent. Cytotoxicity and incorporation assays were performed on MCF-7
and MDA-MB-231 cells within the cell culture studies.

Results:

The uptake value of 99mTc-PAC on MCF-7 cells at 240 minutes was 6.20% and BME treated 99mTc-
PAC value was 17.39%.

Conclusion:

It is observed that BME treatment has a significant effect on the uptake of 99mTc-PAC on MCF-7
cells which is a known estrogen receptor-positive breast carcinoma cell line. It is concluded that this effect could
be due to the estrogen receptor-dependent interaction of BME.
A Review of Multi Agent-based Production Scheduling in Manufacturing System
Authors: Shukla Om Ji , Soni Gunjan , Kumar Rajesh , Ahluwalia Rashpal S.
Published: April 2020

Backgrounds:

The manufacturing sector has seen dynamic changes during the
last few years, namely the move from product-oriented local economy to customer-driven
global economy. In this environment, manufacturing systems have been required to deliver
highly flexible, demand-driven and customized products. Hence, multi agent system (MAS)
technology can play an important role in making highly responsive production scheduling
systems in order to meet dynamic and uncertain changes in demand.

Methods:

This paper
offers a review of MAS for production scheduling problems in manufacturing systems. The
objective of the paper is twofold. First, it describes traditional and MAS based approaches
for different production scheduling problems and presents advantages of MAS over
traditional approaches. Second, it aims to review different MAS platforms and evaluate
some key issues involved in MAS based production scheduling.

Results:

A variety of
different MAS applications in production scheduling is reviewed in four categories of key
issues: agent encapsulation, agent organization, agent coordination & negotiation and agent
learning.

Conclusion:

Finally, this review presents a conceptual framework to implement
MAS in production scheduling and also highlights the future research opportunities as well
as challenges.
Interleukin-19 as an Immunoregulatory Cytokine
Authors: Fujimoto Yasuyuki , Kuramoto Nobuyuki , Yoneyama Masanori , Azuma Yasu-Taka
Published: April 2020

IL-19 is a type of anti-inflammatory cytokine. Since the receptor for IL-19 is common to
IL-20 and IL-24, it is important to clarify the role of each of the three cytokines. If three different
cytokines bind to the same receptor, these three may have been produced to complement the other
two. However, perhaps it is unlikely. Recently, the existence of a novel receptor for IL-19 was
suggested. The distinction between the roles of the three cytokines still makes sense. On the other
hand, because T cells do not produce IL-19, their role in acquired immunity is limited or indirect. It
has been reported that IL-19 causes inflammation in some diseases but does not have an anti-inflammatory
effect. In this review, we introduce the current role of IL-19 in each disease. In addition,
we will describe the molecular mechanism of IL-19 and its development for the prevention of
diseases. IL-19 was previously considered an anti-inflammatory cytokine, but we would like to propose
it as an immunoregulatory cytokine.
RESPONSABILIDADE CIVIL E REGULAÇÃO DE NOVAS TECNOLOGIAS: QUESTÕES ACERCA DA UTILIZAÇÃO DE INTELIGÊNCIA ARTIFICIAL NA TOMADA DE DECISÕES EMPRESARIAIS
Authors: De Teffé Chiara Spadaccini , Medon Filipe
Published: April 2020

RESUMO: O presente artigo tem por objeto central a discussão acerca do regime de responsabilidade civil dos agentes na tomada de decisões baseadas na utilização de sistemas de inteligência artificial. A partir de um panorama acerca da regulação da inteligência artificial no Brasil, passa-se a uma abordagem sintética sobre as principais teorias da responsabilidade civil aplicáveis, utilizando-se como caso para análise a conduta dos agentes empresariais que, no âmbito das sociedades empresárias, delegam decisões, total ou parcialmente, para sistemas automatizados, cujo processo algorítmico nem sempre possui uma explicação clara, mas que, não raro, conduz a danos. Nesse cenário, as normas constitucionais, o dever de diligência e padrões éticos se mostram como parâmetros relevantes para a aferição da responsabilidade civil desses agentes.
A SUPREMA CORTE E A MUDANÇA JURISPRUDENCIAL ACERCA DO DIREITO À NOMEAÇÃO EM CONCURSO PÚBLICO: ENTRE A SOCIOLOGIA POLÍTICA E A VERTENTE NEOINSTITUCIONALISTA
Authors: Santos Francisco Geraldo Matos , Martins Urá Lobato
Published: April 2020

A mudança de entendimento acerca do direito é constante no espaço judiciário. Se de um lado, a segurança jurídica tem sido objeto das investigações feitas pelo campo jurídico, nas ciências sociais a preocupação tem sido em verificar o motivo de tal mudança. Neste texto, fruto de uma pesquisa qualitativa, em que se colacionou dados decisórios – acórdãos - junto ao próprio site do STF, a intenção fora a de verificar a possibilidade de explicações causais concernente à mudança jurisprudencial do Supremo quando do assunto da nomeação em concurso público, se se trata de direito subjetivo ou de mera expectativa de direito. Em nenhum momento ao longo do texto, há menção a discussão e explicação normativa da temática. As pretensas explicações giraram em torno de três análises: mudança das regras (antes e depois da Constituição Federal de 1988), o comportamento decisório dos ministros e a própria composição do STF.
CRISE DOS PRECEDENTES NO SUPREMO: O CASO DOS PRECEDENTES SOBRE LIBERDADE DE EXPRESSÃO
Authors: Hartmann Ivar A.
Published: April 2020

O Supremo Tribunal Federal tem cumprido sua missão de produzir jurisprudência sobre liberdade de expressão capaz de orientar decisões judiciais sobre colisão do direito fundamental à liberdade de expressão com outros direitos de igual hierarquia? A hipótese deste artigo é de que a produção de precedentes de direito material pelo Supremo está em crise há alguns anos e isso afeta também a jurisprudência sobre liberdade de expressão. Após isolar os processos do próprio Supremo que representam 70% das citações feitas em casos de liberdade de expressão no tribunal, analisei cada um individualmente para identificar se continham um holding claro e operacionalizável. Os resultados da pesquisa sustentam a interpretação de que a hipótese foi confirmada. O Supremo realmente fomenta, por meio das escolhas - conscientes ou não - de seus próprios ministros, uma crise de precedentes, ao menos no campo da liberdade de expressão. O tribunal não tem cumprido seu papel de produzir precedentes sobre a proteção da liberdade de expressão, honra e imagem para orientar os magistrados, deixando assim de criar a necessária previsibilidade em relação às decisões judiciais sobre o assunto e, assim, ampliando o chilling effect decorrente da censura judicial privada disseminada no país.