bluuebunny/crossref_metadata_2025 huggingface dataset:
Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of Müller cells via Forkhead box protein O4
Authors: Zhang Jiayu , Wu Liang , Chen Jiawei , Lin Sisi , Cai Daqiu , Chen Chengwei , Chen Zhenguo
Published: February 2018

Background:

Diabetic retinopathy is a neurological disease, which can lead to blindness in severe cases. The pathogenesis underlying diabetic retinopathy is unclear. The aim of this study was to explore the role of dysregulated microRNA 29a/b in the onset and progression of diabetic retinopathy.

Methods:

Diabetes mellitus was induced in rats using 60 mg/kg of streptozotocin. Glucose (5.5 and 25 mM) was used to stimulate rat retinal Müller cells. Real-time polymerase chain reaction and Western blot analyses were used to determine gene expression. A luciferase reporter assay was conducted to validate the relationship of microRNA 29a/b with glioma-associated oncogene homolog 1 and Forkhead box protein O4.

Results:

The expression of microRNA 29a/b and glutamine synthetase decreased in both diabetes mellitus rats and rat retinal Müller cells stimulated with high glucose, whereas the expression of sonic hedgehog, glioma-associated oncogene homolog 1, glial fibrillary acidic protein, and vascular endothelial growth factor, as well as the content of glutamate, increased. Dysregulated microRNA 29a/b was directly regulated by the sonic hedgehog–glioma-associated oncogene homolog 1 signalling pathway, and microRNA 29a and microRNA 29b targeted Forkhead box protein O4 and regulated its expression.

Conclusion:

Downregulation of microRNA 29a/b, mediated by the sonic hedgehog–glioma-associated oncogene homolog 1 signalling pathway, exacerbated diabetic retinopathy by upregulating Forkhead box protein O4.
Performance characterization of multifunctional different cross-sectional-shaped coaxial composite filaments for SMART textile applications
Authors: Afzal Ali , Harzallah Omar , Drean Jean-Yves , Akhtar Niaz-Ahmad , Ahmad Sheraz
Published: February 2018

The aim of this study is to investigate the effect of spinneret design parameters on cross-sectional shape and mechanical performance characteristics of coaxial composite filaments. A number of different cross-sectional-shaped metal/polymer core/sheath coaxial composite filaments were developed by changing spinneret design parameters. The cross-sectional shapes obtained were circular, rectangular, triangular and elliptical shapes. The mechanical performance of filaments was evaluated for application in sensors and actuators. The change of cross-sectional shape significantly influences mechanical properties of developed filaments which express their vulnerability during applied stresses in their life cycle.
Better living through chemistry: Addressing emerging antibiotic resistance
Authors: Coussens Nathan P , Molinaro Ashley L , Culbertson Kayla J , Peryea Tyler , Zahoránszky-Köhalmi Gergely , Hall Matthew D , Daines Dayle A
Published: February 2018

The increasing emergence of multidrug-resistant bacteria is recognized as a major threat to human health worldwide. While the use of small molecule antibiotics has enabled many modern medical advances, it has also facilitated the development of resistant organisms. This minireview provides an overview of current small molecule drugs approved by the US Food and Drug Administration (FDA) for use in humans, the unintended consequences of antibiotic use, and the mechanisms that underlie the development of drug resistance. Promising new approaches and strategies to counter antibiotic-resistant bacteria with small molecules are highlighted. However, continued public investment in this area is critical to maintain an edge in our evolutionary “arms race” against antibiotic-resistant microorganisms.

Impact statement

The alarming increase in antibiotic-resistant microorganisms is a rapidly emerging threat to human health throughout the world. Historically, small molecule drugs have played a major role in controlling bacterial infections and they continue to offer tremendous potential in countering resistant organisms. This minireview provides a broad overview of the relevant issues, including the diversity of FDA-approved small molecule drugs and mechanisms of drug resistance, unintended consequences of antibiotic use, the current state of development for small molecule antibacterials and financial challenges that impact progress towards novel therapies. The content will be informative to diverse stakeholders, including clinicians, basic scientists, translational scientists and policy makers, and may be used as a bridge between these key players to advance the development of much-needed therapeutics.
Making Sense of Genre: The Logic of Video Game Genre Organization
Authors: Vargas-Iglesias Juan J.
Published: February 2018

Despite the importance that the dimension of genre holds in media studies, its very definition in the field of video games is still a matter without consensus. This study intends to outline the logic that lies within the constitution of videoludic genres, understanding them as formal devices configured as per the different thought functions stated by Piaget’s cognitive psychology theory. This project will propose a formalist approach from a cybersemiotic perspective. It seeks to establish a cardinal set of relations to understand the compatibilities and incompatibilities traceable in the syntactic functional order of the different video game genres. Furthermore, a corpus of 43 genres is used to prove the solidity of this theoretical approach, oriented to establish foundations for a praxis of the human–machine ludic relation in fields such as game design and media studies, with the performative character of function as a guiding principle.
Vibration reduction of vehicle-bridge-coupled system using smooth-and-discontinuous absorber
Authors: Yang Xinwei , Wan Tao , Tian Ruilan
Published: February 2018

Three-degree-of-freedom coupled system of vehicle, beam, and smooth-and-discontinuous absorber is constructed to detect the application of smooth-and-discontinuous absorber in vibration reduction of beam subjected to an infinite series of moving vehicles. Smooth-and-discontinuous absorber can be linear absorber or nonlinear one depending on the value of the smoothness parameter. The moving vehicles are simplified as an infinite series of moving spring masses. The amplitude–frequency response functions of the system are obtained using a series of elliptic integrals of the first and second kind. Furthermore, power flow approach is used to detect the effectiveness of smooth-and-discontinuous absorber with parameter variation. The results show that smooth-and-discontinuous absorber can adapt itself to effectively reduce the vibration energy of beam subjected to an infinite series of moving spring masses, which broaden the application of smooth-and-discontinuous absorber in engineering.
Splenic cyst as a rare cause of fetal abdominal cystic mass: A multicenter series of nine cases and review of the literature
Authors: Sepulveda Waldo , Ochoa Jose H , Cafici Daniel , Wong Amy E , Badano Federico , Andreeva Elena , Andreeva Elena Y
Published: February 2018

Introduction

Congenital splenic cysts are a rare cause of abdominal cystic masses in the fetus. We describe nine cases of this condition, the largest reported experience to date. A review of the literature for similar cases was also performed.

Methods

Cases of congenital splenic cyst were collected from three prenatal diagnostic centers and from a dedicated website of prenatal diagnosis. Information regarding clinical and sonographic findings was obtained by reviewing ultrasound reports and medical records. An electronic search of the Pubmed/MEDLINE database for similar cases, with subsequent manual cross-referencing, was performed and the relevant information from the articles was retrieved.

Results

A total of nine cases were added to the currently existing literature of 32 cases. In all but one of our cases, the prenatal detection of the splenic cyst was made in the third trimester, with a median gestational age at diagnosis of 30 weeks (range 22–37). The splenic cyst was confirmed after delivery in all but one case, which was lost to follow up. Postnatal sonographic examinations performed in the remaining eight cases showed that the cyst increased in size in two (25%), was stable in size in one (12%), decreased in size in one (12%), and completely regressed in the other four cases (50%). No complications associated with the cysts were reported in the infants.

Conclusions

Congenital splenic cyst appears to be a benign condition with no known risk of perinatal complications. Nevertheless, differential diagnosis with other fetal cystic masses of the left upper abdominal quadrant and postnatal sonographic follow up to monitor the size of the cyst are important issues to be considered in the perinatal management of these cases.
Fetal adrenal gland biometry and cervical elastography as predictors of preterm birth: A comparative study
Authors: Agarwal Shubhra , Agarwal Arjit , Joon Pawan , Saraswat Shalini , Chandak Shruti
Published: February 2018

Background

Preterm birth is a major health problem in developing and developed countries leading to rising health care costs and long-term neurodevelopmental disability. The study aims to evaluate the role of new quantitative markers, like the elastography of cervix (shear wave speed estimation), fetal adrenal zone enlargement, and corrected fetal adrenal gland volume; in preterm birth prediction and analyze their relative importance. Thus, these markers may be beneficial in early preterm birth detection and prevent the related morbidities.

Methods

Thirty pregnant females (from 28 to 37 weeks of gestational age), showing clinical signs and delivery outcome of preterm birth were included in the study with an equal number of not-in-labor antenatal females at ≥37 weeks as controls. These patients were categorized as preterm and term groups. Both the groups were subjected to trans-abdominal ultrasonography where cervical length, cervical shear wave speed (dynamic elastography) and fetal adrenal gland parameters were measured.

Results

Shear wave speed estimation of the antenatal cervix showed the highest sensitivity and specificity (96.7% and 87% respectively) in the prediction of preterm birth and also showed a strong correlation with fetal adrenal gland enlargement. Fetal adrenal zone enlargement was also shown to be a reliable marker of preterm birth, however, with reduced sensitivity and specificity than shear wave speed.

Conclusion

The elastographic advancement and fetal adrenal biometry derived quantitative markers can be used as an objective and standard criterion for accurate prediction of preterm birth.
Antenatal diagnosis of total anomalous pulmonary venous connection in functional single ventricle hearts: Outcomes over 13-year period
Authors: Fernandes Precylia , Mantagou Lito , Ramaraj Ram , Agarwal Umber , Lim Joyce Su Ling
Published: February 2018

Introduction

A functionally single cardiac ventricle seen on foetal ultrasound scan carries a guarded prognosis. The antenatal diagnosis of anomalous pulmonary venous connection (APVC) remains challenging, if there is no associated structural cardiac abnormality. Antenatally, a combination of complex cardiac anomaly with suspected isomerism should raise the possibility of associated total anomalous pulmonary venous connection (TAPVC). There needs to be a high index of suspicion for TAPVC, in functional single ventricle and suspected isomerism, as this carries a very grim outcome postnatally. We illustrate foetal echocardiographic findings of suspected TAPVC and review outcomes of antenatal versus postnatal diagnosis of TAPVC with functional single ventricle.

Methods

We retrospectively reviewed our database over 13 years, focusing on foetal cardiac diagnosis, pregnancy outcomes, management and outcomes of livebirths with diagnosis of TAPVC with functional single ventricle.

Results

Thirteen patients were included in the review. For the nine antenatal patients, three pregnancies were terminated and six babies were born alive (four babies had compassionate care, two babies had cardiac surgery). One baby is alive at 8.5 years, after Fontan surgery. For the four postnatal patients, three babies had compassionate care (one alive at age 8.1 years) and one baby had cardiac surgery (died age nine weeks). Ten of the 13 patients have right atrial isomerism. Of these 10 patients, only two are alive. For the three non-isomeric babies, only one baby is still alive. There is heterogeneity of the type of TAPVC diagnosed with no particular group that offered better survival.

Conclusion

Antenatal diagnosis of TAPVC, even in the context of functional single ventricle remains challenging. If isomerism is suspected, targeted evaluation of pulmonary venous connection should be done. This combination of cardiac lesion carries a very grim outcome. The ability to make this diagnosis antenatally will add to the information and counselling given to these parents.
Sonographic parameters for diagnosing fetal head engagement during labour
Authors: Wiafe Yaw A , Whitehead Bill , Venables Heather , Odoi Alexander T
Published: February 2018

The purpose of this study was to investigate the diagnostic performance of the head–perineum distance, angle of progression, and the head–symphysis distance as intrapartum ultrasound parameters in the determination of an engaged fetal head. Two hundred and one women in labour underwent both ultrasound and digital vaginal examination in the estimation of fetal head station. The transperineal ultrasound measured head–perineum distance, angle of progression, and head–symphysis distance for values correlating with digital vaginal examination head station. Using station 0 as the minimum level of head engagement, correlating cut-off values for head–perineum distance, angle of progression, and head–symphysis distance were obtained. Receiver operating characteristics were used in determining the diagnostic performance of these cut-off values for the detection of fetal head engagement. With head–perineum distance of 3.6 cm the sensitivity and specificity of sonographic determination of engaged fetal head were 78.7 and 72.3%, respectively. A head–symphysis distance of 2.8 cm also had sensitivity and specificity of 74.5 and 70.8%, respectively, in determining engagement, whilst an angle of progression of 101° was consistent with engagement by digital vaginal examination with 68.1% sensitivity and 68.2% specificity. Ultrasound shows high diagnostic performance in determining engaged fetal head at a head–perineum distance of ≤3.6 cm, head–symphysis distance of ≤2.8 cm, and angle of progression of ≥ 101°.
The implications of women’s activity limitations and role disruptions during breast cancer survivorship
Authors: Keesing Sharon , Rosenwax Lorna , McNamara Beverley
Published: February 2018

Early survivorship is a time of critical transition for women survivors of breast cancer as they attempt to resume functional activities and important life roles. This study aimed to explore the challenges of women and their partners as they attempted to resume activities and roles, identify unmet needs and make recommendations regarding a suitable framework to support women and partners to recommence valued activities and important roles during early survivorship.

Qualitative methods utilising in-depth interviews of women (n = 18) and their partners (n = 8), and two focus groups (n = 10) were completed in Perth, Western Australia, between June 2014 and April 2015. These methods were used to facilitate women and partners’ views regarding the resumption of previously meaningful activities and important life roles during early survivorship. Questions addressed their individual and shared experiences concerning self-care, leisure, social and productive activities and important roles. Thematic analysis was employed to determine themes.

Women and partners reported significant impact on their ability to engage in valued activities, resulting in changes to participation in meaningful roles. Three themes were determined: (1) ambiguity regarding survivorship prevents resumption of activities and previous roles, (2) breast cancer continues to impact a couples’ relationship during survivorship, and (3) support is needed to assist women and partners to resume activities and important roles.

This research provides evidence suggesting that the ongoing symptoms of breast cancer treatment continue to impact many women and their partners, as they attempt to resume functional activities and important life roles during early survivorship. Disruption to these valued activities and roles may influence women and their partner’s health and well-being during early survivorship and extend beyond this period. Rehabilitation following cessation of treatment could be offered as required to facilitate access to multi-disciplinary services and supports for both individuals and couples.
A conditional random field model for name disambiguation in National Natural Science Foundation of China fund
Authors: Si Hang Jun , Tong Weiqin , Kausar Samina
Published: February 2018

The name ambiguity problem affects the accuracy of the web search, document retrieval, and information fusion. A lot of work has been done to solve the name disambiguation problem for publication or paper, but we propose a model to solve this problem for the National Natural Science Foundation of China fund. In this paper, we propose a probabilistic Markov random fields framework to solve the problem of the National Natural Science Foundation of China fund name disambiguation. We define an objective function and use parameters learning algorithm to get the suitable parameters. Experimental results indicate that our approach significantly outperforms other different traditional clustering methods.
Management of fracture-dislocations of the little finger carpometacarpal joint: a systematic review
Authors: Cobb Will A. , Dingle Lewis , Zarb Adami Raina , Rodrigues Jeremy
Published: February 2018

Fracture-dislocations of the carpometacarpal joint (CMCJ) of the little ray involve dorsal subluxation of the metacarpal base and they may be associated with injury of neighbouring CMCJs. Different treatment options are described, with no clear consensus on their management. This study presents a systematic review of comparative studies describing the management of these injuries. A bespoke search strategy was applied across multiple databases. Results were screened against specified stepwise inclusion criteria and data were extracted independently by two authors with discrepancy resolution by a third. Of 437 search results, six comparative studies were identified. Comparisons included non-operative or early mobilization versus fixation K-wires or open reduction and internal fixation. Conclusions were mixed; all studies had critical or significant risks of bias (using the ROBINS-I tool) and there was heterogeneity between studies.
Rectal bleeding
Authors: Babakhanlou Rodrick
Published: February 2018

Bleeding per rectum is defined as the passage of blood from the anus. It is a common presentation in adults of all ages and the majority of cases can be managed in primary care. This article will focus on the common causes of rectal bleeding, its assessment and management, including guidance for referral pathways to secondary care.
Frequent Emergency Department Visits After Spontaneous Intracerebral Hemorrhage: Who Is at Risk?
Authors: Nogueira Jerina , Abreu Pedro , Guilherme Patrícia , Félix Ana Catarina , Ferreira Fátima , Nzwalo Hipólito , Marreiros Ana
Published: February 2018

Background:

The long-term prognosis of spontaneous intracerebral hemorrhage (SICH) is poor. Frequent emergency department (ED) visits can signal increased risk of hospitalization and death. There are no studies describing the risk of frequent ED visits after SICH.

Methods:

Retrospective cohort study of a community representative consecutive SICH survivors (2009-2015) from southern Portugal. Logistic regression analysis was performed to identify sociodemographic and clinical factors associated with frequent ED visits (≥4 visits) within the first year after hospital discharge.

Results:

A total of 360 SICH survivors were identified, 358 (98.6%) of whom were followed. The median age was 72; 64% were males. The majority of survivors (n = 194, 54.2%) had at least 1 ED visit. Reasons for ED visits included infections, falls with trauma, and isolated neurological symptoms. Forty-four (12.3%) SICH survivors became frequent ED visitors. Frequent ED visitors were older and had more hospitalizations ( P < .001) and ED visits ( P < .001) prior to the SICH, unhealthy alcohol use ( P = .049), longer period of index SICH hospitalization ( P = .032), pneumonia during hospitalization ( P = .001), and severe neurological impairment at discharge ( P = .001). Pneumonia during index hospitalization (odds ratio [OR]: 3.08; confidence interval [CI]: 1.39-6.76; P = .005) and history of ED visits prior to SICH (OR: 1.64; CI: 1.19-2.26, P = .003) increased the likelihood of becoming a frequent ED visitor.

Conclusions:

Predictors of frequent ED visits are identifiable at hospital discharge and during any ED visit. Improvement of transitional care and identification of at-risk patients may help reduce multiple ED visits.
Moxifloxacin-induced tinnitus in an older adult
Authors: Onoh Amber , Linnebur Sunny A. , Fixen Danielle R.
Published: February 2018

An increased risk of bacterial resistance toward fluoroquinolones and the increased risk of disabling and serious adverse effects prompted the US Food and Drug Administration to recommend limiting fluoroquinolone use to the treatment of community-acquired pneumonia, skin and skin-structure infections, bacterial sinusitis, plague, chronic bronchitis exacerbations, and complicated intra-abdominal infections. We report a case of moxifloxacin-induced tinnitus in an older adult prescribed oral moxifloxacin 400 mg for 5 days for the treatment of acute diverticulitis, due to allergies to nonfluoroquinolone preferred agents. A thorough literature review provided few other reported incidents of this rare and serious adverse event.
Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine
Authors: De Berardis Domenico , Rapini Gabriella , Olivieri Luigi , Di Nicola Domenico , Tomasetti Carmine , Valchera Alessandro , Fornaro Michele , Di Fabio Fabio , Perna Giampaolo , Di Nicola Marco , Serafini Gianluca , Carano Alessandro , Pompili Maurizio , Vellante Federica , Orsolini Laura , Martinotti Giovanni , Di Giannantonio Massimo
Published: February 2018

Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it has remained the drug of choice in treatment-resistant schizophrenia, despite a wide range of adverse effects, as it is a very effective drug in everyday clinical practice. However, clozapine is not considered as a top-of-the-line treatment because it may often be difficult for some patients to tolerate as some adverse effects can be particularly bothersome (i.e. sedation, weight gain, sialorrhea etc.) and it has some other potentially dangerous and life-threatening side effects (i.e. myocarditis, seizures, agranulocytosis or granulocytopenia, gastrointestinal hypomotility etc.). As poor treatment adherence in patients with resistant schizophrenia may increase the risk of a psychotic relapse, which may further lead to impaired social and cognitive functioning, psychiatric hospitalizations and increased treatment costs, clozapine adverse effects are a common reason for discontinuing this medication. Therefore, every effort should be made to monitor and minimize these adverse effects in order to improve their early detection and management. The aim of this paper is to briefly summarize and provide an update on major clozapine adverse effects, especially focusing on those that are severe and potentially life threatening, even if most of the latter are relatively uncommon.
Aging-like physiological changes in the skin of Japanese obese diabetic patients
Authors: Ibuki Ai , Kuriyama Shoko , Toyosaki Yukiko , Aiba Misaki , Hidaka Moeko , Horie Yoshiko , Fujimoto Chihiro , Isami Fumiyuki , Shibata Eriko , Terauchi Yasuo , Akase Tomoko
Published: February 2018

Objective:

Obesity-associated diabetes causes aging-like changes to skin physiology in animal models, but there have been no clinical studies focusing on human obese diabetic patients. The purpose of this study was to examine the hypothesis that obesity-associated diabetes accelerates aging-like skin changes in Japanese people.

Methods:

This cross-sectional study enrolled obese-diabetes patients (body mass index ≥ 25 kg m−2) and healthy volunteers (body mass index < 25 kg m−2) as controls. Skin physiology parameters relating to aging (stratum corneum hydration, transepidermal water loss, skin pH, advanced glycation end-products, and dermal collagen density) were evaluated in the two groups.

Results:

About 37 subjects participated (16 in a control group and 21 in an obese-diabetes group). Age was not significantly different between the groups. The stratum corneum hydration level was significantly lower in the obese-diabetes group. Transepidermal water loss and levels of advanced glycation end-products were significantly higher in this group. Skin pH was not significantly different between groups. Dermal collagen density decreased in the obese-diabetes group.

Conclusion:

We showed that obese-diabetes patients have decreased stratum corneum hydration, increased transepidermal water loss, higher skin advanced glycation end-products and decreased dermal collagen fiber density compared with normal-weight subjects. These results indicate that the ordinary age-related physiological skin changes seen in the elderly can also occur in obese-diabetes patients aged in their 40s.
Demand and Unmet Needs of Contraception Among Sexually Active In-Union Women in Nigeria: Distribution, Associated Characteristics, Barriers, and Program Implications
Authors: Fagbamigbe Adeniyi Francis , Afolabi Rotimi Felix , Idemudia Erhabor Sunday
Published: February 2018

It is not clear whether the 16% unmet need for contraceptives in Nigeria indicates a success story. This study assessed the contraceptive prevalence rate (CPR), total contraceptive demand, and unmet needs and determined the distribution, determinants, and barriers to contraceptive demands and unmet needs in Nigeria. The fertility, breastfeeding, and contraceptive use information provided by 27,829 women who were either currently married or in a sexual union in the 2013 Nigeria Demographic and Health Survey (NDHS) were extracted. Associations between having unmet needs and the demographic, socioeconomic, and reproductive profiles of the respondents were assessed using bivariate and multiple logistic regression at 5% significance level. Multiple response data analysis techniques were used to assess barriers to nonuse of contraceptives. Data were weighted to reflect differentials in the population of in-union women in each geographical state. The modern CPR was 9.8% while total demand for contraception was 31.2%, consisting of unmet need at 16.1% and met needs at 15.1%. Unmet need for family planning was higher among rural women compared with urban women (16.8% vs. 14.9%); younger women (adjusted odds ratio [aOR] = 4.29; confidence interval [CI] = [3.03, 6.07]), women belonging to poorer economic status (aOR = 2.27, CI = [1.92, 2.68]), and women with no education (aOR = 3.23, CI = [2.60, 4.02]) had higher odds of unmet needs. The low unmet need should not be mistaken for a good progress in family planning programming in Nigeria; the success is better measured using the level of total demand for contraceptives and CPR. Interventions to improve the socioeconomic status of women, increase the knowledge of modern contraceptives, and improve women’s decision-making power should be prioritized.
Fixation of Traumatic Chondral-Only Fragments of the Knee in Pediatric and Adolescent Athletes: A Retrospective Multicenter Report
Authors: Fabricant Peter D. , Yen Yi-Meng , Kramer Dennis E. , Kocher Mininder S. , Micheli Lyle J. , Lawrence J. Todd R. , Ganley Theodore J. , Heyworth Benton E.
Published: February 2018

Background:

While traditional biological principles have suggested that fragments consisting of cartilage alone cannot be reaffixed to bone with expectable long-term healing, case reports of successful healing after fixation in younger patients indicate that this concept remains incompletely explored.

Purpose:

To evaluate the presenting features, techniques, healing rates, and clinical and radiological results in a cohort of pediatric and adolescent athletes who underwent fixation of traumatic chondral-only fragments in the knee.

Study Design:

Case series; Level of evidence, 4.

Methods:

Patient registries at 2 tertiary care children’s hospitals were reviewed to identify patients ≤18 years old who underwent fixation of a “chondral-only” fragment in the knee, defined as the inability to visualize the fragment on injury radiographs or discern bone on the articular portion of a fragment intraoperatively. The mechanism of injury, fragment features, fixation technique, and postoperative clinical course, including timing of sports clearance, healing on postoperative magnetic resonance imaging (MRI), and any complications or reoperations, were assessed.

Results:

Fifteen patients with a median age at surgery of 12.7 years (interquartile range [IQR], 11.7-14.2 years) and median follow-up of 12.0 months (IQR, 6.0-19.2 months) were analyzed. All patients sustained an acute knee injury before surgery. The injured sites, as assessed on MRI, were the patella (n = 6), trochlea (n = 5), and lateral femoral condyle (n = 4). The median fragment surface area was 492.0 mm2 (IQR, 400.0-787.5 mm2). Fixation with bioabsorbable implants was performed in all patients at a median of 1.6 weeks (IQR, 1.0-2.6 weeks) after the injury. One patient (7%) sustained a fall 8 weeks postoperatively, requiring secondary surgery for excision of a dislodged fragment, and 1 patient (7%) underwent unrelated patellar stabilization surgery 3.4 years postoperatively, at which time the fragment was found to be stable. MRI was performed in 9 of 14 patients with retained fragments (median, 12.0 months postoperatively), with 5 patients (56%) showing restoration of the cartilage contour and the resolution of subchondral edema; 2 patients showed thinning but intact cartilage, 1 had cartilage thickening, and 1 had subchondral edema, fissuring, and cystic changes. The median time to return to sports for all 15 patients was 26.0 weeks (IQR, 22.8-40.9 weeks), including 2 patients who required second surgery and returned to sports at 26.1 and 191.1 weeks.

Conclusion:

Fixation of traumatic chondral-only fragments using bioabsorbable implants may result in successful short-term healing in the majority of pediatric and adolescent athletes.
Harry Potter and the First Order of Business: Using Simulation to Teach Social Justice and Disability Ethics in Business Communication
Authors: Wheeler Stephanie K.
Published: February 2018

Despite the excellent work by scholars who invite us to consider disability, social justice, and business and professional communication pedagogy, little attention has been given to what a disability- and social-justice-centered business and professional communication course might look like in design and implementation. This case study offers an example of a simulation based within the Harry Potter universe that emphasizes the ways disability advocacy and civic engagement manifest themselves in foundational business writing theories and practices. This simulation enabled students to engage with social justice issues by understanding access as an essential part of business and professional communication.
Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children
Authors: Barua Priyanka , Chandrasiri Upeksha P. , Beeson James G. , Dewey Kathryn G. , Maleta Kenneth , Ashorn Per , Rogerson Stephen J.
Published: February 2018

Background

There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age.

Methods

The study was conducted with a subset of 432 Malawian children from a randomized controlled trial of nutritional supplements. The arms included pre- and postnatal small-quantity lipid-based nutrient supplements for both mother and child; prenatal supplementation with iron and folic acid; and pre- and postnatal supplementation with multiple micronutrients. Paired plasma samples were collected at 6 and 18 months of age. The levels of antibodies against merozoite surface protein 1 (MSP1 19kD) and MSP2, erythrocyte binding antigen 175 (EBA175), reticulocyte binding protein homologue 2A (Rh2A9), schizont extract and variant antigens expressed on the surface of infected erythrocytes were measured.

Results

At 18 months of age, 5.4% of children were parasitaemic by microscopy and 49.1% were anaemic. Antibodies to the tested merozoite antigens and schizont extract increased between 6 and 18 months and this increase was statistically significant for MSP1, MSP2 and EBA175 (p < 0.0001) whereas IgG to variant surface antigens decreased with increasing age (p < 0.0001). However, the supplementation type did not have any impact on the prevalence or levels of antibodies at either 6 or 18 months of age to any of the tested malaria antigens in either univariate analysis or multivariate analysis after adjusting for covariates.

Conclusions

Pre- and postnatal lipid-based nutrient supplementation did not alter malaria antibody acquisition during infancy, compared to prenatal supplementation with iron and folic acid or pre- and postnatal supplementation with multiple micronutrients.

Trail registerationClinicaltrials.gov registration number NCT01239693
Discrimination between some Mycoplasma spp. and Acholeplasma laidlawii in bovine milk using high resolution melting curve analysis
Authors: Al-Farha Abd Al-Bar , Petrovski Kiro , Jozani Razi , Hoare Andrew , Hemmatzadeh Farhid
Published: February 2018

Objectives

This study aimed to provide a rapid, accurate and cost-effective diagnostic real time polymerase chain reaction-high resolution melting curve assay (PCR-HRM) to identify and distinguish between four different mycoplasmas and Acholeplasma laidlawii isolated at cow-level from a single commercial dairy farm in South Australia. One set of genus-level universal primers was designed targeting the 16S ribosomal RNA gene.

Results

Real time PCR-HRM analysis was able to identify and distinguish between five different mollicutes, namely A. laidlawii, M. arginini, M. bovirhinis, M. bovis and uncultured Mycoplasma. Results were confirmed through sequencing. Our developed assay provides rapid and accurate screening for Mycoplasma mastitis detection.
Enforcement of labor market regulations: heterogeneous compliance and adjustment across gender
Authors: Viollaz Mariana
Published: February 2018

This paper explores microdata from Argentine household surveys to analyze how changes in the enforcement of labor regulations affect the compliance level and other labor outcomes among men and women. Using information of the highly decentralized labor inspection system in Argentina, I construct an enforcement measure with variation at the province, sector, and time level (share of inspected firms) which I instrument using a measure of the arrival cost of labor inspectors to the firms. The main findings reveal that when enforcement increases, the compliance with mandated benefits and formal wages increase among men, while informal wages decline. Among women, the compliance level declines jointly with informal wages. These heterogenous impacts are explained by labor regulations that make formal and informal men more substitutable in the production process than formal and informal women.
Particle swarm optimization for simultaneous analysis of magnetotelluric and time-domain electromagnetic data
Authors: Santilano Alessandro , Godio Alberto , Manzella Adele
Published: February 2018

We have developed an innovative, simultaneous 1D optimization of electromagnetic (EM) data. Our scheme is suitable for the simultaneous analysis of magnetotelluric (MT) and time-domain EM (TDEM) data based on the probabilistic and evolutionary particle swarm optimization (PSO) algorithm. The simultaneous optimization also identifies and removes the static shift from the MT data. In our scheme, the static shift of the MT apparent resistivity curve is considered as an additional parameter [Formula: see text] to be optimized. We tested the suggested method on the synthetic data and then applied it to the data from an EM geophysical study carried out in the geothermal area of Larderello-Travale (Tuscany, Italy). Apart from the novelty of using the PSO algorithm to estimate the model parameters by joint analysis, the simultaneous optimization of the static shift parameter addresses a major problem in MT, i.e., how to define and remove the galvanic effects on MT curves according to independent information, such as that provided by TDEM data. The procedure is expected to strongly influence the application of MT, particularly in geothermal exploration, which commonly relies extensively on EM methods.
Ground-roll attenuation using curvelet downscaling
Authors: Naghizadeh Mostafa , Sacchi Mauricio
Published: February 2018

We have developed a ground-roll attenuation strategy for seismic records that adopts the curvelet transform. The curvelet transform decomposes the seismic events based on their dip and frequency content information. The curvelet panels that contain only either reflection or ground-roll energy can be used to alter the curvelet panels with mixed reflection and ground-roll energies. We build a curvelet-domain mask function from the ground-roll-free curvelet coefficients (high frequencies) and downscale it to the ground-roll-contaminated curvelet coefficients (low frequencies). The mask function is used inside a least-squares optimization scheme to preserve the seismic reflections and attenuate the ground roll. Synthetic and real seismic data examples show the application of the proposed ground-roll attenuation method.
Mais que um negócio, um propósito [entrevistado por Aline Lilian dos Santos]
Authors: Borges Alexandre
Published: February 2018

Ter um negócio é mais do que trabalho para Alexandre Borges, sócio e atual CEO da Mãe Terra, empresa especializada em produtos naturais e orgânicos. Seu apreço pela terra veio ainda criança, quando morava no interior de São Paulo, tornando-se algo visceral. Assim, a Mãe Terra é a realização de um sonho e um propósito de vida para ele. Adquirida em 2008, a empresa cresce mais de 40% ao ano e é uma das maiores do setor. Com um amplo portfólio de grãos, cereais, massas e snacks, deve expandir ainda mais suas ações, entrando no segmento de sucos e fortalecendo a linha de produtos para o público infantil. Empreendedor nato, o ex-aluno da FGV/EAESP está em seu terceiro negócio e mostra que, mesmo com poucos recursos, é possível construir uma marca de sucesso por meio do empenho, da disciplina e da criatividade. Em entrevista exclusiva à GV-executivo, Alexandre fala sobre sua trajetória, dá dicas de empreendedorismo e aponta as tendências do mercado de produtos naturais e orgânicos, que está em crescente e constante ascensão.
An explanatory model for the concept of mental health in Iranian youth
Authors: Chinekesh Ahdieh , Hosseini Seyed Ali , Mohammadi Farahnaz , Motlagh Mohammad Esmael , Baradaran Eftekhari Monir , Djalalinia Shirin , Ardalan Gelayol
Published: February 2018

Background: Mental health is considered as an integral and essential component of overall health. Its determinants and related factors are one of the most important research priorities, especially in adolescents and young people. Using a qualitative approach, the present study aimed to identify factors affecting the mental health of youth in Iran.

Methods: In 2017, following content analysis principles, and using semi-structured in-depth interviews, we conducted a qualitative study exploring the opinions of young people about mental health. A targeted sampling method was used, and participants were young volunteers aged 18 to 30 who were selected from Tehran province, Iran. Inclusion criteria for participants was willingness to participate in the study, and ability to express their experiences. Data collection was done with individual in-depth interviews. According to the explanatory model, the interviews were directed toward the concept of mental health and path of causality and auxiliary behaviors.

Results: 21 young adults participated, who met the study inclusion criteria, of whom 12 participants were male. Their mean age was 24.4 ± 0.41 years and their education varied from primary school to Master’s degree. Mental health was considered as mental well-being and a sense of satisfaction and efficacy, not only the presence of a disease or mental disorder. Based on the opinions of the interviewees, three factors of personal characteristics, family and society are involved in mental health. Individual factors were associated with behavioral and physical problems. One of the most important issues was revealed as tensions in societal and family conflicts. Economic problems and unemployment of young people were also extracted from the social factor.

Conclusion: In Iran, social factors such as jobs for the unemployed and job security are considered as important determinants in the mental health of young people.
Portable respiratory polygraphy monitoring of obese mothers the first night after caesarean section with bupivacaine/morphine/fentanyl spinal anaesthesia
Authors: Hein Anette , Jakobsson Jan G.
Published: February 2018

Background:Obesity, abdominal surgery, and intrathecal opioids are all factors associated with a risk for respiratory compromise. The aim of this explorative trial was to study the apnoea/hypopnea index 1st postoperative night in obese mothers having had caesarean section (CS) in spinal anaesthesia with a combination of bupivacaine/morphine and fentanyl.

Methods:Consecutive obese (BMI >30 kg/m 2) mothers, ≥18 years, scheduled for CS with bupivacaine/morphine/fentanyl spinal anaesthesia were monitored with a portable polygraphy device Embletta /NOX on 1stpostoperative night. The apnoea/hypopnea index (AHI) was identified by clinical algorithm and assessed in accordance to general guidelines; number of apnoea/hypopnea episodes per hour: <5 “normal”, ≥5 and <15mild sleep apnoea, ≥15 and <30moderate sleep apnoea,≥ 30severe sleep apnoea. Oxygen desaturation events were in similar manner calculated per hour as oxygen desaturation index (ODI).

Results:Forty mothers were invited to participate: 27 consented, 23 were included, but polysomnography registration failed in 3. Among the 20 mothers studied: 11 had an AHI <5 (normal), 7 mothers had AHI ≥5 but <15 (mild OSAS) and 2 mothers had AHI ≥15 (moderate OSA), none had an AHI ≥ 30. The ODI was on average 4.4, and eight patients had an ODI >5. Mothers with a high AHI (15.3 and 18.2) did not show high ODI. Mean saturation was 94% (91-96%), and four mothers had mean SpO290-94%, none had a mean SpO2 <90%.

Conclusion:Respiratory polygraphy 1stnight after caesarean section in spinal anaesthesia with morphine in moderately obese mothers showed AHIs that in sleep medicine terms are considered normal, mild and moderate. Obstructive events and episodes of desaturation were commonly not synchronised. Further studies looking at preoperative screening for sleep apnoea in obese mothers are warranted but early postop respiratory polygraphy recording is cumbersome and provided sparse important information.
Genetic analysis of measles virus nucleocapsid gene identifies measles virus isolate of close similarity to Clade A viruses from Nigeria
Authors: Faneye Adedayo O. , Adeniji Johnson A. , Motayo Babatunde O.
Published: February 2018

Previous studies on the molecular epidemiology of measles virus in Nigeria shows that genotype B3 clusters 1 and 2 are the circulating measles genotype. We report the isolation of measles virus strain of close similarity to reference genotype A measles virus strain from Ibadan, Nigeria. Molecular characterization of a measles virus isolate from a child presenting with fever and rash in a hospital in Ibadan, Nigeria, was done by measles virus isolation in Vero slam cell line, RT-PCR and direct sequencing of the COOH terminal of the nucleoprotein gene of the measles virus isolate. Phylogenetic analysis of the sequence shows that isolate MViIbadan, NIE/11.01 clustered with the reference strains of Clade A. Our current report shows evidence of another circulating MV genotype different from the previously reported genotype B3 in Nigeria. We advocate for expanded national molecular surveillance of measles virus as this will aid in achieving the country’s goal of control of the disease.
Comparing manual and mechanically assisted manipulations of the thoracic spine in neck pain patients: A pilot study
Authors: Langenfeld Anke , Humphreys B. Kim , de Bie Rob A. , Swanenburg Jaap
Published: February 2018

Background: Manipulations of the thoracic spine are a common treatment option in patients with neck pain. This approach avoids the risk of cervical arterial dissection. Currently there are different options available which have been evaluated for their efficacy. The aim of this study was to assess short- and long-term effects of two different methods of manipulating the thoracic spine in combination with a standardized exercise program for neck pain.

Methods: This pilot study included patients who were over 18 years of age, able to speak and read German or English, had acute or chronic neck pain, and had not previously undergone manual therapy for the thoracic spine. Patients were recruited from private physical therapy practices. Patients were randomly assigned to two treatment groups by using block randomization. The objective was to compare the effects of manually performed manipulations and electromechanical manipulations on the thoracic spine in patients with neck pain. Primary outcome was the visual analogue pain rating scale. Secondary outcomes included Neck Disability Index, European Quality of Life scale, and Patients’ Global Impression of Change Scale.

Results: Ten patients were recruited. Five patients received manual manipulations, and five received electromechanical manipulations. Both groups showed an improvement in pain scores (VAS) (X2 (5) = 14.161, p = 0.015) with no difference between the groups. There were no significant changes in the secondary outcomes. The electromechanical (Impulse iQ®) manipulations group showed a clinically relevant reduction in the neck disability index.

Conclusion: Both manual and electromechanical manipulations are well tolerated, and show that they can be both successful treatments for neck pain in combination with exercises. Thoracic manipulations seem to be beneficial for the patient’s complaint of neck pain, while electromechanical manipulations seem to be able to reduce neck disability.

Trial registration: Current Controlled Trials ISRCTN88585962, registered in January 2013.