bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender and Migrant Roles in Italian Neorealist and New Migrant Films: Cinema as an Apparatus of Reconfiguration of National Identity and ‘Otherness’
Authors: Charitonidou Marianna
Published: April 2021

The article examines an ensemble of gender and migrant roles in post-war Neorealist and New Migrant Italian films. Its main objective is to analyze gender and placemaking practices in an ensemble of films, addressing these practices on a symbolic level. The main argument of the article is that the way gender and migrant roles were conceived in the Italian Neorealist and New Migrant Cinema was based on the intention to challenge certain stereotypes characterizing the understanding of national identity and ‘otherness’. The article presents how the roles of borgatari and women function as devices of reconceptualization of Italy’s identity, providing a fertile terrain for problematizing the relationship between migration studies, urban studies and gender studies. Special attention is paid to how migrants are related to the reconceptualization of Italy’s national narrations. The Neorealist model is understood here as a precursor of the narrative strategies that one encounters in numerous films belonging to the New Migrant cinema in Italy. The article also explores how certain aspects of more contemporary studies of migrant cinema in Italy could illuminate our understanding of Neorealist cinema and its relation to national narratives. To connect gender representation and migrant roles in Italian cinema, the article focuses on the analysis of the status of certain roles of women, paying particular attention to Anna Magnagi’s roles.
Gait Speed as a Predictor for Diabetes Incidence in People with or at Risk of Knee Osteoarthritis: A Longitudinal Analysis from the Osteoarthritis Initiative
Authors: Alenazi Aqeel M. , Alqahtani Bader A. , Vennu Vishal , Alshehri Mohammed M. , Alanazi Ahmad D. , Alrawaili Saud M. , Khunti Kamlesh , Segal Neil A. , Bindawas Saad M.
Published: April 2021

Background: This study examined the association between baseline gait speed with incident diabetes mellitus (DM) among people with or at elevated risk for knee OA. Materials and Methods: Participants from the Osteoarthritis Initiative, aged 45 to 79 years, where included. Participants with or at risk of knee OA from baseline to the 96-month visit were included. Participants with self-reported DM at baseline were excluded. DM incidence was followed over the 4-time points. Gait speed was measured at baseline using a 20-m walk test. Generalized estimating equations with logistic regression were utilized for analyses. Receiver operator characteristic curves and area under the curve were used to determine the cutoff score for baseline speed. Results: Of the 4313 participants included in the analyses (58.7% females), 301 participants had a cumulative incidence of DM of 7.0% during follow-up. Decreased gait speed was a significant predictor of incident DM (RR 0.44, p = 0.018). The threshold for baseline gait speed that predicted incident DM was 1.32 m/s with an area under the curve of 0.59 (p < 0.001). Conclusions: Baseline gait speed could be an important screening tool for identifying people at risk of incident diabetes, and the determined cutoff value for gait speed should be examined in future research.
Factors Hindering Social Participation among Older Residents from Evacuation Zones after the Nuclear Power Plant Accident in Fukushima: The Fukushima Health Management Survey
Authors: Harigane Mayumi , Imuta Hiromi , Yasumura Seiji , Hayashi Fumikazu , Nakano Hironori , Ohira Tetsuya , Maeda Masaharu , Yabe Hirooki , Suzuki Yuriko , Kamiya Kenji ,   on behalf of the Mental Health Group of the Fukushima Health Management Survey
Published: April 2021

Considering the health effects of radiation accompanying the nuclear power plant accident that occurred in the wake of the Great East Japan Earthquake, this study aimed to examine social participation after the disaster and factors hindering participation among citizens aged ≥ 65 years from designated evacuation zones inside the Fukushima prefecture. The target population comprised 180,604 residents in 13 municipalities containing designated evacuation zones. There were 73,433 valid responses (response rate, 40.7%); of which, data from 19,573 respondents aged ≥ 65 years were analyzed. Multinomial logistic regression analyses were conducted to investigate the factors associated with social participation. In total, 53.0% of older evacuees did not participate in recreational activities or communal services. Stratified analysis showed that living outside the Fukushima prefecture and requiring assistance with activities of daily living were associated with low social participation. This study clarified that the majority of older evacuees did not participate in social activities at the time of the survey within one year of the disaster. Furthermore, where these older individuals were evacuated to and whether they were able to live independently might have affected their social participation. Better subjective health, better sleep quality, and more frequent exercise may be associated with improved social participation.
Multidimensional Model of Environmental Attitudes: Evidence Supporting an Abbreviated Measure in Spanish
Authors: Andrade Elena , Seoane Gloria , Velay Luis , Sabucedo Jose-Manuel
Published: April 2021

We conducted three independent studies to support the Spanish version of the Environmental Attitudes Inventory (EAI). The first study consisted of translating and pre-testing on a sample of 125 college students. The second consisted of testing the EAI on a sample of 225 university students in several undergraduate courses. Student data were collected using two different methods, through an online teaching platform and in the classroom. The findings were symmetrical in terms of precision and dimensionality. The third study completed the aforementioned ones testing the items on a representative sample from the general population in Spain. The participants were 630 citizens from 17 regions and responded to the EAI using an online platform. The results of the factor analysis led us to propose a measurement model, with 18 items and six first-order factors: environmental movement activism, conservation motivated by anthropocentric concern, confidence in science and technology, personal conservation behaviour, human dominance over nature, and support for population growth policies. External validity evidence was assessed by the correlation with the following variables: neuroticism, ecological behaviour, limits to economic growth, economic liberalism, sustainability, altruism, and social desirability. These estimations stayed away from demographic and personal aspects such as age, sex, political ideology, and region.
Effect of Seawater Temperature Increase on the Occurrence of Coastal Vibrio vulnificus Cases: Korean National Surveillance Data from 2003 to 2016
Authors: Kim Jungsook , Chun Byung Chul
Published: April 2021

The purpose of this study was to assess the association between seawater temperature and Vibrio vulnificus cases in coastal regions of Korea. All V. vulnificus cases in coastal regions notified to the Korea Disease Control and Prevention Agency between 2003 and 2016 were included in this work. Data for seawater temperature on the south, west, and east coast during the study period were provided by the Korea Oceanographic Data Center of the National Institute of Fisheries Science. We used a generalized additive model and performed a negative binomial regression analysis. In total, 383 notified cases were analyzed (west coast: 196 cases, south coast: 162, and east coast: 25). The maximum seawater temperature was the most significant predictor of V. vulnificus cases on the south and east coasts (relative risk according to the 1 °C increase in seawater temperature (RR) = 1.35 (95% confidence interval (CI): 1.19–1.53) and 1.30 (95% CI: 1.06–1.59), respectively). However, the mean seawater temperature was the most significant predictor for the west coast (RR = 1.34 (95% CI: 1.20–1.51)). These results indicate that continuously monitoring seawater temperature increase in each coastal area is crucial to prevent V. vulnificus infections and protect high-risk groups, such as persons with liver disease.
Repeat Induced Abortion among Chinese Women Seeking Abortion: Two Cross Sectional Studies
Authors: Tang Longmei , Wu Shangchun , Liu Dianwu , Temmerman Marleen , Zhang Wei-Hong
Published: April 2021

Background: In China, there were about 9.76 million induced abortions in 2019, 50% of which were repeat abortions. Understanding the tendency of repeat induced abortion and identifying its related factors is needed to develop prevention strategies. Methods: Two hospital-based cross-sectional surveys were conducted from 2005–2007 and 2013–2016 in 24 and 90 hospitals, respectively. The survey included women who sought an induced abortion within 12 weeks of pregnancy. The proportion of repeat induced abortions by adjusting the covariates through propensity score matching was compared between the two surveys, and the zero-inflated negative binomial regression model was established to identify independent factors of repeat induced abortion. Results: Adjusting the age, occupation, education, marital status and number of children, the proportion of repeat induced abortions in the second survey was found to be low (60.28% vs. 11.11%), however the unadjusted proportion was high in the second survey (44.97% vs. 51.54%). The risk of repeat induced abortion was higher among married women and women with children [ORadj and 95% CI: 0.31 (0.20, 0.49) and 0.08 (0.05, 0.13)]; the risk among service industry staff was higher when compared with unemployed women [ORadj and 95% CI: 0.19 (0.07, 0.54)]; women with a lower education level were at a higher risk of a repeat induced abortion (ORadj < 1). Compared with women under the age of 20, women in other higher age groups had a higher frequency of repeat induced abortions (IRadj: 1.78, 2.55, 3.27, 4.01, and 3.93, separately); the frequency of women with lower education levels was higher than those with a university or higher education level (IRadj > 1); the repeat induced abortion frequency of married women was 0.93 (0.90, 0.98) when compared to the frequency of unmarried women, while the frequency of women with children was 1.17 (1.10, 1.25) of childless women; the induced abortion frequency of working women was about 60–95% with that of unemployed women. Conclusions: The repeat induced abortion proportion was lower than 10 years ago. Induced abortion seekers who were married, aged 20 to 30 years and with a lower education level were more likely to repeat induced abortions.
Do Age and Educational Stage Influence No-Mobile-Phone Phobia?
Authors: Rodríguez-García Antonio-Manuel , Marín-Marín José-Antonio , López-Núñez Juan-Antonio , Moreno-Guerrero Antonio-José
Published: April 2021

Technological progress not only brings with it resources that improve and facilitate the day-to-day life of the people who make up society but also entails health risks, with the emergence of terms, such as nomophobia, which is considered an anxiety disorder produced by the fear that not having a mobile phone generates in a person. This research aims to identify the relationship and influence between levels of nomophobia and the age or educational stage of students. The research method is based on a correlational and predictive design of quantitative methodology. The instrument used is the NMP-Q questionnaire. The study population is students from different educational stages (obligatory secondary education, baccalaureate, vocational training and university). The results show that students over 12 years old present an average level of “nomophobia” (no-mobile-phone phobia), namely, not being able to communicate with the family where the highest levels are presented. We conclude that students over 12 years of age and of any educational stage present an average level of nomophobia, and it cannot be determined that either the educational stage or the age are determining factors in the presentation of this problem. This can occur at any age and at any level of the different educational stages, although there are risk indicators that we should bear in mind to avoid the appearance of nomophobia.
Bored to Be Wild: How Boredom Is Related to Pre-Service Teachers’ Intention to Persist in Their Studies
Authors: Audrin Catherine , Hascoët Marine
Published: April 2021

Boredom is an emotion that often arises in an educational context. Past research suggests that boredom depends on specific cognitive appraisals, such as how people can control the task and how much they value it. Research further suggests that boredom is related to negative academic outcomes such as lower grades and a higher risk of dropping out. Here, we tested a mediation model on 324 pre-service teachers during the first lockdown of 2020 in Switzerland to assess (1) how control and value predicted boredom, and (2) how boredom was related to the intention to persist at university. We hypothesized that (1) the more participants felt lacking in control and low in value, the higher their boredom and (2) the more intense their boredom, the lower their intention to persist. We further hypothesized that both control and value would be positively related to the intention to persist, and this link may be mediated by boredom. Our results provide partial support for our mediation model as we found a significant indirect link between control and intention to persist through boredom. More specifically, the more participants lost control over their studies, the more they felt bored, which in turn was negatively related to their intention to persist.
The Use of Hyperbaric Oxygen Therapy and Corticosteroid Therapy in Acute Acoustic Trauma: 15 Years’ Experience at the Czech Military Health Service
Authors: Holy Richard , Zavazalova Sarka , Prochazkova Klara , Kalfert David , Younus Temoore , Dosel Petr , Kovar Daniel , Janouskova Karla , Oniscenko Boris , Fik Zdenek , Astl Jaromir
Published: April 2021

Background: Acute acoustic trauma (AAT) ranks, among others, as one common cause of inner ear function impairment, especially in terms of military personnel, who are at an increased exposure to impulse noises from firearms. Aim of this study: 1. We wanted to demonstrate whether early treatment of AAT means a higher chance for the patient to improve hearing after trauma. 2. We find the answer to the question of whether hyperbaric oxygen therapy (HBO2) has a positive effect in the treatment of AAT. Methods: We retrospectively analyzed data for the period 2004–2019 in patients with AAT. We evaluated the therapeutic success of corticosteroids and HBO2 in a cohort of patients with AAT n = 108 patients/n = 141 affected ears. Results: Hearing improvement after treatment was recorded in a total of 111 ears (79%). In terms of the data analysis we were able to ascertain, utilizing success of treatment versus timing: within 24 h following the onset of therapy in 56 (40%) ears—54 (96%) ears had improved; within seven days following the onset the therapy was used in 55 (39%) ears—41 (74%) ears had improved; after seven days the therapy started in 30 (21%) ears—16 (53%) ears had improved. Parameter latency of the beginning of the treatment of AAT was statistically significant (p = 0.001 and 0.017, respectively). The success of the medical protocols was apparent in both groups—group I (treated without HBO2): n = 61 ears, of which 50 (82%) improved, group II (treated with HBO2): n = 73 ears, of which 56 (77%) improved. Group II shows improvement at most frequencies (500–2000 Hz). The most serious sensorineural hearing loss after AAT was at a frequency of 6000 Hz. Conclusion: Analysis of our data shows that there is a statistically significant higher rate of improvement if AAT treatment was initiated within the first seven days after acoustic trauma. Early treatment of AAT leads to better treatment success. HBO2 is considered a rescue therapy for the treatment of AAT. According to our recommendation, it is desirable to start corticosteroid therapy immediately after acoustic trauma. If hearing does not improve during the first seven days of corticosteroid therapy, then HBO2 treatment should be initiated.
Biochar Mediated-Alleviation of Chromium Stress and Growth Improvement of Different Maize Cultivars in Tannery Polluted Soils
Authors: Bashir Muhammad Asaad , Wang Xiukang , Naveed Muhammad , Mustafa Adnan , Ashraf Sobia , Samreen Tayyaba , Nadeem Sajid Mahmood , Jamil Moazzam
Published: April 2021

Soil pollution with heavy metal is a serious problem across the globe and is on the rise due to the current intensification of chemical industry. The leather industry is one of them, discharging chromium (Cr) in huge quantities during the process of leather tanning and polluting the nearby land and water resources, resulting in deterioration of plant growth. In this study, the effects of biochar application at the rate of 3% were studied on four maize cultivars, namely NK-8441, P-1543, NK-8711, and FH-985, grown in two different tannery polluted Kasur (K) and Sialkot (S) soils. Maize plants were harvested at vegetative growth and results showed that Cr toxicity adversely not only affected their growth, physiology, and biochemistry, but also accumulated in their tissues. However, the level of Cr toxicity, accumulation, and its influence on maize cultivars varied greatly in both soils. In this pot experiment, biochar application played a crucial role in lessening the Cr toxicity level, resulting in significant increase in plant height, biomass (fresh and dry), leaf area, chlorophyll pigments, photosynthesis, and relative water content (RWC) over treatment set as a control. However, applied biochar significantly decreased the electrolyte leakage (EL), antioxidant enzymes, lipid peroxidation, proline content, soluble sugars, and available fraction of Cr in soil as well as Cr (VI and III) concentration in root and shoot tissues of maize plant. In addition to this, maize cultivar differences were also found in relation to their tolerance to Cr toxicity and cultivar P-1543 performed better over other cultivars in both soils. In conclusion, biochar application in tannery polluted soils could be an efficient ecofriendly approach to reduce the Cr toxicity and to promote plant health and growth.
Influence of Surgical Flap Design (Envelope and Szmyd) for Removal of Impacted Mandibular Third Molars on Clinical Periodontal Parameters: A Clinical Trial
Authors: Ahmad Muhtada , Khan Zafar Ali , Khan Tahir Ullah , Alqutub Montaser N. , Mokeem Sameer A. , AlMubarak Abdulrahman M. , Haider Mehmood , Al-Askar Mansour , Ahmed Naseer , Aldahiyan Nada , Vohra Fahim , Abduljabbar Tariq
Published: April 2021

The aim of the study was to assess the influence of flap designs (Envelope flap (EF) and Szmyd flap (SF)) for impacted mandibular third molar extraction, on periodontal pocket depth (PPD), clinical attachment loss (CAL) and bone levels (BL) of second molar. Sixty patients indicated for third molar extractions with healthy second molars were allocated into two groups: EF and SF (n = 30). Third molars were assessed for angulation, root patterns, depth of impactions and relation with ramus (Pell and Gregory classification). Extraction of third molars was performed and PPD, CAL and BL around second molars at 0, 3 and 6 month (mon) follow-ups (FU) were assessed clinically and radiographically. ANOVA, Chi-square and Fisher’s exact test were employed to compare periodontal factors between EF and SF groups, considering p ≤ 0.05 as significant. Sixty participants with a mean age of 23.22 ± 3.17 were included in the study. Based on angulation, the most common impaction in the EF and SF groups was mesio-angular (EF, 50%; SF, 36.7%). Buccal and distal PPD showed a significant increase (p < 0.001) in both EF and SF patients from baseline to 6 mon. EF patients showed significantly higher distal and buccal CAL (6.67 ± 0.18 mm; 6.91 ± 0.17 mm) and BL (7.64 ± 0.16 mm; 7.90 ± 0.15 mm) as compared to SF patients (CAL, 6.76 ± 0.26 mm; 6.91 ± 0.17 mm-BL, 7.42 ± 0.38 mm; 7.34 ± 0.34 mm) at 6 mon FU. SF showed better soft tissue attachment (PPD and CAL) and bone stability (less bone loss) around second molars compared to EF after third molar extractions regardless of the patient, tooth and operator factors.
Biodegradation of Chloroxylenol by Cunninghamella elegans IM 1785/21GP and Trametes versicolor IM 373: Insight into Ecotoxicity and Metabolic Pathways
Authors: Nowak Marta , Zawadzka Katarzyna , Szemraj Janusz , Góralczyk-Bińkowska Aleksandra , Lisowska Katarzyna
Published: April 2021

Chloroxylenol (PCMX) is applied as a preservative and disinfectant in personal care products, currently recommended for use to inactivate the SARS-CoV-2 virus. Its intensive application leads to the release of PCMX into the environment, which can have a harmful impact on aquatic and soil biotas. The aim of this study was to assess the mechanism of chloroxylenol biodegradation by the fungal strains Cunninghamella elegans IM 1785/21GP and Trametes versicolor IM 373, and investigate the ecotoxicity of emerging by-products. The residues of PCMX and formed metabolites were analysed using GC-MS. The elimination of PCMX in the cultures of tested microorganisms was above 70%. Five fungal by-products were detected for the first time. Identified intermediates were performed by dechlorination, hydroxylation, and oxidation reactions catalysed by cytochrome P450 enzymes and laccase. A real-time quantitative PCR analysis confirmed an increase in CYP450 genes expression in C. elegans cells. In the case of T. versicolor, spectrophotometric measurement of the oxidation of 2,20-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) showed a significant rise in laccase activity during PCMX elimination. Furthermore, with the use of bioindicators from different ecosystems (Daphtoxkit F and Phytotoxkit), it was revealed that the biodegradation process of PCMX had a detoxifying nature.
Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control
Authors: Takata Tomoaki , Isomoto Hajime
Published: April 2021

Diabetes mellitus is a major cause of chronic kidney disease and end-stage renal disease. However, the management of chronic kidney disease, particularly diabetes, requires vast improvements. Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treatment of diabetes, have been shown to protect against kidney injury via glycemic control, as well as various other mechanisms, including blood pressure and hemodynamic regulation, protection from lipotoxicity, and uric acid control. As such, regulation of these mechanisms is recommended as an effective multidisciplinary approach for the treatment of diabetic patients with kidney disease. Thus, SGLT2 inhibitors are expected to become key drugs for treating diabetic kidney disease. This review summarizes the recent clinical evidence pertaining to SGLT2 inhibitors as well as the mechanisms underlying their renoprotective effects. Hence, the information contained herein will advance the current understanding regarding the pleiotropic effects of SGLT2 inhibitors, while promoting future research in the field.
Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells
Authors: Seol Binna , Kim Young-Dae , Cho Yee Sook
Published: April 2021

Sialidosis, caused by a genetic deficiency of the lysosomal sialidase gene (NEU1), is a systemic disease involving various tissues and organs, including the nervous system. Understanding the neurological dysfunction and pathology associated with sialidosis remains a challenge, partially due to the lack of a human model system. In this study, we have generated two types of induced pluripotent stem cells (iPSCs) with sialidosis-specific NEU1G227R and NEU1V275A/R347Q mutations (sialidosis-iPSCs), and further differentiated them into neural precursor cells (iNPCs). Characterization of NEU1G227R- and NEU1V275A/R347Q- mutated iNPCs derived from sialidosis-iPSCs (sialidosis-iNPCs) validated that sialidosis-iNPCs faithfully recapitulate key disease-specific phenotypes, including reduced NEU1 activity and impaired lysosomal and autophagic function. In particular, these cells showed defective differentiation into oligodendrocytes and astrocytes, while their neuronal differentiation was not notably affected. Importantly, we found that the phenotypic defects of sialidosis-iNPCs, such as impaired differentiation capacity, could be effectively rescued by the induction of autophagy with rapamycin. Our results demonstrate the first use of a sialidosis-iNPC model with NEU1G227R- and NEU1V275A/R347Q- mutation(s) to study the neurological defects of sialidosis, particularly those related to a defective autophagy–lysosome pathway, and may help accelerate the development of new drugs and therapeutics to combat sialidosis and other LSDs.
Towards the Interpretability of Machine Learning Predictions for Medical Applications Targeting Personalised Therapies: A Cancer Case Survey
Authors: Banegas-Luna Antonio Jesús , Peña-García Jorge , Iftene Adrian , Guadagni Fiorella , Ferroni Patrizia , Scarpato Noemi , Zanzotto Fabio Massimo , Bueno-Crespo Andrés , Pérez-Sánchez Horacio
Published: April 2021

Artificial Intelligence is providing astonishing results, with medicine being one of its favourite playgrounds. Machine Learning and, in particular, Deep Neural Networks are behind this revolution. Among the most challenging targets of interest in medicine are cancer diagnosis and therapies but, to start this revolution, software tools need to be adapted to cover the new requirements. In this sense, learning tools are becoming a commodity but, to be able to assist doctors on a daily basis, it is essential to fully understand how models can be interpreted. In this survey, we analyse current machine learning models and other in-silico tools as applied to medicine—specifically, to cancer research—and we discuss their interpretability, performance and the input data they are fed with. Artificial neural networks (ANN), logistic regression (LR) and support vector machines (SVM) have been observed to be the preferred models. In addition, convolutional neural networks (CNNs), supported by the rapid development of graphic processing units (GPUs) and high-performance computing (HPC) infrastructures, are gaining importance when image processing is feasible. However, the interpretability of machine learning predictions so that doctors can understand them, trust them and gain useful insights for the clinical practice is still rarely considered, which is a factor that needs to be improved to enhance doctors’ predictive capacity and achieve individualised therapies in the near future.
Effect of Cavity Disinfectants on Adhesion to Primary Teeth—A Systematic Review
Authors: Coelho Ana , Amaro Inês , Apolónio Ana , Paula Anabela , Saraiva José , Ferreira Manuel Marques , Marto Carlos Miguel , Carrilho Eunice
Published: April 2021

Some authors have been proposing the use of cavity disinfectants in order to reduce, or even eliminate, the effect of the microorganisms present in a dental cavity before a restoration is placed. The aim of this study was to evaluate the effect of different cavity disinfectants on bond strength and clinical success of composite and glass ionomer restorations on primary teeth. The research was conducted using Cochrane Library, PubMed/MEDLINE, SCOPUS, and Web of Science for articles published up to February 2021. The search was performed according to the PICO strategy. The evaluation of the methodological quality of each in vitro study was assessed using the CONSORT checklist for reporting in vitro studies on dental materials. Sixteen in vitro studies and one in situ study fulfilled the inclusion criteria and were analyzed. Chlorhexidine was the most studied cavity disinfectant, and its use does not compromise dentin bonding. Sodium hypochlorite is a promising alternative, but more research on its use is required to clearly state that it can safely be used as a cavity disinfectant for primary teeth. Although other disinfectants were studied, there is a low-level evidence attesting their effects on adhesion, therefore their use should be avoided.
Preliminary Validation of Steel Slag-Aggregate Concrete for Rigid Pavements: A Full-Scale Study
Authors: Revilla-Cuesta Víctor , Ortega-López Vanesa , Skaf Marta , Pasquini Emiliano , Pasetto Marco
Published: April 2021

The high wear resistance and toughness of electric arc furnace slag (EAFS) means that this industrial by-product can successfully replace natural aggregate in hydraulic or bituminous concretes that withstand vehicle traffic. This article validates the use of concrete made with large amounts of EAFS for rigid pavements. Accordingly, three EAFS–concrete mixes made with metallic or synthetic fibers were designed. Their performance was studied through laboratory tests (compressive strength, modulus of elasticity, splitting tensile strength, and abrasion resistance) and field observations on full-scale slabs made with each of the studied mixes. All mechanical properties yielded adequate results for concrete for rigid pavements. The metallic fibers increased the strength and elastic stiffness by 7–10%, while the addition of synthetic fibers slowed the development of these properties over time. On the other hand, all the mixes allowed for a successful implementation of full-scale slabs, with none of them showing excessive deterioration after five years of exposure to the outdoor environment. Only minor cracking and some chips in the surface-treatment layer were detected. The strength development of the slabs and their slipperiness were adequate for use in high-speed pavements. The overall analysis of the results shows that concrete made with EAFS can be used in real rigid pavements.
Development of Sterile Insect Technique for Control of the European Grapevine Moth, Lobesia botrana, in Urban Areas of Chile
Authors: Simmons Gregory. S. , Salazar Sepulveda Melissa Cristal , Fuentes Barrios Edith Alejandra , Idalsoaga Villegas Marcela , Medina Jimenez Raul Enrique , Garrido Jerez Alvaro Rodrigo , Henderson Ruth , Donoso Riffo Hernán
Published: April 2021

The European grapevine moth, a Palearctic pest, was first detected in the Americas in 2008. Its establishment in Chile presented production and export issues for grapes and other fruits, and a national control campaign was launched. Urban areas next to agricultural production areas were recognized as a challenge for effective control. In 2015, a SIT laboratory was established in Arica, Chile to evaluate its potential for urban control. Progress included the development and evaluation of artificial diets, a mass-rearing of 75,000 moths/week, confirmation of 150 Gy as an operational dose for inherited sterility, and releases of sterile moths in a 25 ha urban area next to fruit production areas. Season-long releases demonstrated that high overflooding ratios were achieved early in the season but decreased with a large increase in the wild moth population. Sterile moth quality was consistently high, and moths were observed living in the field up to 10 days and dispersing up to 800 m. Recommendations for further development of the SIT include conducting cage and field studies to evaluate overflooding ratios and mating competitiveness, measuring of infestation densities in release and no-release areas, and conducting trials to evaluate combining SIT with compatible integrated pest management (IPM) tactics such as fruit stripping and use of mating disruption.
Long-Term Halo Follow-Up Confirms Less Invasive Treatment of Low-Grade Cartilaginous Tumors with Radiofrequency Ablation to Be Safe and Effective
Authors: Nijland Hendricus , Overbosch Jelle , Ploegmakers Joris J. W. , Kwee Thomas C. , Jutte Paul C.
Published: April 2021

Background: Radiofrequency ablation (RFA) is a minimally invasive alternative in the treatment of bone tumors. Long-term follow-up has not been described in current literature. Detailed analysis of mid- and long-term follow-up after RFA treatment for a cohort of patients with low-grade cartilaginous tumors (atypical cartilaginous tumors and enchondroma) was performed. The results, complications, and development of halo dimensions over time are presented. Methods: Data of all patients with an RFA procedure for an ACT between 2007–2018 were included. Ablation area is visible on baseline MRI, 3 months post-procedure, and is called halo. Volume was measured on MR images and compared to different follow-up moments to determine the effect of time on halo volume. Follow-up was carried out 3 months and 1, 2, 5, and 7 years after the procedure. Occurrence of complications and recurrences were assessed. Results: Of the 137 patients included, 82 were analyzed. Mean follow-up time was 43.6 months. Ablation was complete in 73 cases (89.0%). One late complication occurred, while no recurrences were seen. Halo dimensions of height, width, and depth decreased with a similar rate, 21.5% on average in the first year. Subsequently, this decrease in halo size continues gradually during follow-up, indicating bone revitalization. Conclusion: RFA is a safe and effective treatment in low-grade cartilaginous tumors with an initial success rate of 89.0%. Extended follow-up shows no local recurrences and gradual substitution of the halo with normal bone.
Multivessel Intervention in Myocardial Infarction with Cardiogenic Shock: CULPRIT-SHOCK Trial Outcomes in the PL-ACS Registry
Authors: Gąsior Mariusz , Desperak Piotr , Dudek Dariusz , Witkowski Adam , Buszman Paweł E. , Trzeciak Przemysław , Hawranek Michał , Gierlotka Marek , Bartuś Stanisław , Grygier Marek , Zembala Michał , Stępińska Janina , Legutko Jacek , Wojakowski Wojciech
Published: April 2021

Background: The aim of the study was a comparison of culprit-lesion-only (CL-PCI) with the multivessel percutaneous coronary intervention (MV-PCI) in terms of 30-day and 12-month mortality in a national registry. Methods: Patients from the PL-ACS registry with MI and CS were analyzed. Patients meeting the criteria of the CULPRIT-SHOCK trial were divided into two groups: CL-PCI and MV-PCI groups. Results: Of the 3265 patients in the PL-ACS registry with MI complicated by CS, the criteria of the CULPRIT-SHOCK trial were met by 2084 patients (63.8%). The CL-PCI was performed in 883 patients, and MV-PCI was performed in 1045 patients. After the propensity score matching analysis, 617 well-matched pairs were obtained. In a 30-day follow-up, death from any cause occurred in 49.3% in the CL-PCI group and 57.0% in the MV-PCI group (RR 0.86, 95% CI 0.58–0.92, p = 0.0081). After 12 months, the rate of mortality was 62.5% in the CL-PCI group and 68.0% in the MV-PCI group (RR 0.92, 95% CI 0.84–1.01, p = 0.066). Conclusions: The results confirm the validity of CULPRIT-SHOCK findings in a national registry and current guideline-recommended strategy of revascularization limited to the infarct-related artery.
The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients
Authors: Zihlif Malek , Imraish Amer , Al-Rawashdeh Baeth , Qteish Aya , Husami Raihan , Husami Rawand , Tahboub Farah , Jarrar Yazun , Lee Su-Jun
Published: April 2021

Total serum immunoglobulin E (IgE) is elevated in multiple allergic diseases and is considered a good predictor of atopy. Several studies have been performed on the association of IgE levels with the polymorphism of the ADAM33 gene in asthmatic patients. The aim of this study was to determine whether there is an association between IgE levels and the genetic polymorphisms of the ADAM33 gene (T1, T2, T + 1, V4, S1, S2, and Q-1) in both healthy and asthmatic patients among Jordanians. The clinical data were collected for this case–control study from 267 asthmatic patients and 225 control subjects. Seven genetic polymorphisms (T1, T2, T + 1, V4, S1, S2, and Q-1) of the gene ADAM33 were analyzed using the polymerase chain reaction/restriction fragment length polymorphism method. The minor alleles (G) of T1, (A) of T2, T + 1, and (G) of V4 polymorphisms were associated with a significant increase in total serum IgE levels in adults but not children. The V4 genetic polymorphism, however, showed a significant association with IgE levels in both adults and children. The S1 polymorphism was significantly associated with the codominant module only in the adults. The S2 polymorphism showed a significant association (p-value < 0.05) in both codominant and recessive models. However, in the dominant model for both pediatric control and asthmatic patients, the association between the IgE and S2 polymorphism was insignificant (p-value = 0.7271 and 0.5259, respectively). This study found a statistically significant association between multiple ADAM33 genetic polymorphisms and IgE levels. Such findings add to the growing evidence that the ADAM33 gene has a major impact on IgE levels among asthmatic patients of Jordanian origin.
Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes
Authors: Rodríguez-Martínez Aitor , Trapero Carla , Vidal August , Piulats Josep Maria , Gómez de Aranda Inmaculada , Sévigny Jean , Fernández-Montolí Maria Eulàlia , Ponce Jordi , Matias-Guiu Xavier , Martín-Satué Mireia
Published: April 2021

Ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) has been described in human non-pathological endometrium in both epithelial and stromal components without changes along the cycle. It was identified as a stromal marker of basalis. In the present study, we aimed to evaluate NTPDase2 distribution, using immunolabeling and in situ enzyme activity approaches, in endometrial carcinoma (EC) at different tumor grades. NTPDase2 was present in tumor epithelial EC cells, as in the non-pathological endometria, but the expression underwent changes in subcellular distribution and also tended to decrease with the tumor grade. In stroma, NTPDase2 was identified exclusively at the tumor-myometrial junction but this expression was lost in tumors of invasive phenotype. We have also identified in EC samples the presence of the perivascular population of endometrial mesenchymal stem cells (eMSCs) positive for sushi domain containing 2 (SUSD2) and for NTPDase2, already described in non-tumoral endometrium. Our results point to NTPDase2 as a histopathological marker of tumor invasion in EC, with diagnostic relevance especially in cases of EC coexisting with other endometrial disorders, such as adenomyosis, which occasionally hampers the assessment of tumor invasion parameters.
Characterizing Urban Expansion Combining Concentric-Ring and Grid-Based Analysis for Latin American Cities
Authors: Wu Su , Sumari Neema Simon , Dong Ting , Xu Gang , Liu Yanfang
Published: April 2021

Spatio-temporal characterization of urban expansion is the first step towards understanding how cities grow in space. We summarize two approaches used in urban expansion measurement, namely, concentric-ring analysis and grid-based analysis. Concentric-ring analysis divides urban areas into a series of rings, which is used to quantify the distance decay of urban elements from city centers. Grid-based analysis partitions a city into regular grids that are used to interpret local dynamics of urban growth. We combined these two approaches to characterize the urban expansion between 2000–2014 for five large Latin American cities (São Paulo, Brazil; Mexico City, Mexico; Buenos Aires, Argentina; Bogotá, Columbia; Santiago, Chile). Results show that the urban land (built-up area) density in concentric rings decreases from city centers to urban fringe, which can be well fitted by an inverse S curve. Parameters of fitting curves reflect disparities of urban extents and urban form among these five cities over time. Grid-based analysis presents the transformation of population from central to suburban areas, where new urban land mostly expands. In the global context, urban expansion in Latin America is far less rapid than countries or regions that are experiencing fast urbanization, such as Asia and Africa. Urban form of Latin American cities is particularly compact because of their rugged topographies with natural limitations.
Assessing the Impacts of Rural Development Plan Measures on the Sustainability of Agricultural Holdings Using a PMP Model
Authors: Moulogianni Christina , Bournaris Thomas
Published: April 2021

Rural Development Plan (RDP) measures support farmers in improving the sustainability of their agricultural holdings. The implementation of these policies has economic, social, and environmental impacts, which are monitored either ex-ante, ongoing, or ex-post, as required from the European Commission impact assessment guidelines. In this frame, this paper aims to assess the impacts of RDP measures on the sustainability of agricultural holdings. For this reason, a positive mathematical programming (PMP) model was developed and implemented in combination with a set of economic, social, and environmental indicators. The model was used to assess the ex-post impacts of the measure titled ‘Modernization of agricultural holdings’ of the Greek RDP 2007–2013. This research was conducted on a sample of 219 agricultural holdings in a region of northern Greece. The impacts were measured through the changes of the crop plan in the agricultural land. The results show that the measure has positive economic impacts, negative social impacts, and negative impacts on most of the environmental indicators. The results also underline the significant role of the impact assessment process in supporting policymakers in understanding the impacts of their policies.
Band-Pass Filtering Cross-Polarization Converter Using Transmitarrays
Authors: Feng Jialin , Shi Hongyu , Yi Jianjia , Zhang Anxue , Xu Zhuo
Published: April 2021

Microwave devices with polarization conversion and band-pass filtering response have great application prospects on radomes. Here, the concepts of band-pass filters and cross-polarization converters are combined to realize a band-pass filtering cross-polarization converter with an extremely high polarization-conversion ratio. Most importantly, the device has an excellent out-of-band rejection level, above 30 and 40 dB for the lower and upper edges, respectively. In addition, the transmission zeros of the passband can be flexibly tuned independently. The band-pass filtering polarization converter was simulated, fabricated, and measured, and the measured results were found to be in good agreement with the simulation results.
Strength Properties of Sustainable Mortar Containing Waste Steel Slag and Waste Clay Brick: Effect of Temperature
Authors: Miah Md Jihad , Paul Suvash Chandra , Babafemi Adewumi John , Panda Biranchi
Published: April 2021

The use of waste streams for the production of sustainable cement-based materials cannot be overemphasized. This study investigates the feasibility of reusing waste steel slag (WSS) and waste clay brick (WCB) as a replacement for natural sand (NS) in mortar. Numerous studies have reported mainly the compressive strength of concrete/mortar, while limited research is available that focuses on the tensile and flexural strength of mortar, and especially the performance at elevated temperature. Hence, this study investigates the tensile and flexural strength of mortar with three different replacement percentages (0, 50 and 100% by volume of NS) of NS by WSS and WCB at normal temperature (without thermal treatment) and after exposure to elevated temperatures (250, 400 and 600 °C). At ambient condition, both tensile and flexural strength were enhanced as the WSS content increased (76 and 68%, respectively, at 100% WSS). In comparison, the strength increased at 50% WCB (25 and 37%, accordingly) and decreased at 100% WCB (23 and 20%, respectively) compared to 100% NS. At elevated temperatures, both the tensile and flexural strength of mortar mixes decreased significantly at 600 °C.
Calculation Method of Permanent Deformation of Asphalt Mixture Based on Interval Number
Authors: Xiao Yue , Tang Limin , Xie Jiawei
Published: April 2021

There are great uncertainties in road design parameters, and the traditional point numerical calculation results cannot reflect the complexity of the actual project well. Additionally, the calculation method of road design theory based on interval analysis is more difficult in the use of uncertain design parameters. In order to simplify the calculation process of the interval parameters in the road design theory, the asphalt pavement design is taken as the analysis object, and the permanent deformation of the asphalt mixture is simplified by combining the interval analysis theory. Considering the uncertainty of the design parameters, the data with boundaries but uncertain size are expressed in intervals, and then the interval calculation formula for the permanent deformation of the asphalt mixture is derived, and the interval results are obtained. In order to avoid the dependence of interval calculation on the computer code, according to the interval calculation rule, the interval calculation method with the upper and lower end point values as point operations is proposed. In order to overcome the contradiction between interval expansion results and engineering applications, by splitting the multi-interval variable formulas, the interval variable weights are reasonably given, and the synthesis of each single interval result realizes a simplified calculation based on interval variable weight assignment. The analysis results show that the interval calculation method based on the point operation rule is accurate and reliable, and the simplified method based on the interval variable weight assignment is effective and feasible. The simplified interval calculation method proposed in this paper provides a reference for the interval application of road design theory.
Sliding State Analysis of Fractal Rough Interface Based on the Finite Element Method
Authors: Wu Jianpeng , Wang Liyong , Li Le , Shu Yuechao , Yang Li , Lei Tonghui
Published: April 2021

Local high temperature, stress concentration, and abnormal friction coefficients will appear at the friction pair in a wet clutch as a result of surface topography real-time changing. In order to improve the reliability of clutch friction components and reduce the failure phenomenon, the three-dimensional fractal surface topography data of the actual rough surface asperities are scanned, extracted, and processed successively, and then the finite element model of the rotary sliding friction pair is established considering the micro surface topography. Based on the finite element model, the variation of surface stress and strain is analyzed, and the friction coefficient measured experimentally is taken as the model input. It is concluded that when the rough surface and smooth surface make contact with each other, the maximum stress and plastic strain appear at the inner radius edge. Therefore, this research has a guiding significance for the structural design and processing technology of the friction components in a vehicle clutch.