bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Dalam Meningkatkan Kinerja Karyawan Pada Best Western Kindai Hotel Banjarmasin
Authors: Hidayat Ikhsan Rafi , Ghalib Saladin , Fitriyadi Fitriyadi , Hairudinor Hairudinor
Published: March 2022

This study aims to see whether the training provided by the Best Western Kindai Hotel Banjarmasin has been effective or not. In the process, this study uses qualitative methods where the results show that the training provided by the Best Western Kindai Hotel Banjarmasin to its employees has shown effective results in its implementation. .Basically, the company always wants every training that is carried out to be effective and produce effective output as well. In its efforts, the Best Western Kindai Hotel Banjarmasin always strives for how every training given is always effective and produces effective outputs too, by bringing in trainers who are competent in their fields with the hope of meeting the factors of effectiveness itself, such as Trainer Clarity, Training Place, Communication Trainers and Training Materials so as to achieve effective training and achieve the vision and mission of the company. Keywords : Training, Effectiveness, Trainer, Trainer Clarity, Training Place, TrainerCommunication, and Training Materials.
Pengaruh Varian Menu, Harga, dan Suasana Cafe, Terhadap Kepuasan Konsumen Cafe Miltie Garden Mulawarman Banjarmasin
Authors: Sihombing Meika Marito , Arifin Muhammad Hasanur , Maryono Maryono
Published: March 2022

The study aims to determine and test the effect partially and simultaneously Variant Menu (X1), Price (X2), and Cafe Atmosphere (X3) on Customer Satisfaction (Y). This study uses a quantitative approach. The number of samples was 97 people using Non-Probability Sampling technique. Data collection techniques by means of questionnaires and data analysis techniques used are Multiple Linear Analysis using SPSS 25.0. The test results show that the Menu Variant (X1) with a sig value of 0.020 with a large influence of 0.20 or 20.6% has a positive and significant effect on consumer satisfaction. Price (X2) with a sig value of 0.001 with a large influence of 0.304 or 30.4% has a negative and significant effect on customer satisfaction. Cafe atmosphere (X3) with a sig value of 0.013 with a large influence of 0.229 or 22.9% has a positive and significant effect on consumer satisfaction. Meanwhile, based on the simultaneous test (F test), it can be seen that F count in the sig = 0,000 column which shows a number less than 0.05 or 0,000<0,05 with a Determinant Coefficient Value (R2) with a large effect of 0.681 or 68.1%, while 31.9% is from other variables not examined in this study.  Keywords: Menu Variants, Prices, Cafe Atmosphere, Customer Satisfaction
Pengaruh Diskon dan Kualitas Layanan Elektronik terhadap Kepuasan Pelanggan pada Aplikasi Tix ID di Kota Banjarmasin
Authors: Ermida Nadya Eka , Ghalib Saladin , Wahyuni Nurul
Published: March 2022

Marketing is all efforts that start from identifying the needs of consumers, determining the right product or service to be marketed, coordinating with other management functions, and developing offers through promotional and distribution strategies. This study aims to determine the effect of discounts and electronic service quality partially and simultaneously on customer satisfaction. Respondents in this study were users of the Tix ID application in Banjarmasin City who were taken using the accidental sampling technique, so that there were 110 respondents who used the Tix ID application as the research sample. Data collection techniques by means of questionnaires and data analysis techniques used are multiple linear regression analysis using SPSS 25.0. The results of this study indicate that partially the discount variable (X1) has no significant effect on customer satisfaction (Y) with a significant value of 0.293> 0.05 with a t value of 1.056 <t table 1.982, and electronic service quality (X2) has a significant effect on customer satisfaction (Y) with a significant value of 0.000 <0.05 with a value of t count 12.080> t table 1.982. Simultaneously, the discount variable (X1) and the quality of electronic services (X2) have a significant effect on customer satisfaction (Y) with a significant value of 0.000 <0.05 with a calculated F value of 84.978> F table 3.08. Keywords: Discounts, Electronic Service Quality, Customer Satisfaction
PENGARUH EARNING PER SHARE (EPS), DEVIDEND PER SHARE (DPS) DAN PRICE EARNING RATIO (PER) TERHADAP HARGA SAHAM PT. BANK RAKYAT INDONESIA, TBK PERIODE 2015-2019
Authors: Rifani Muhammad , Arifin Muhammad Hasanur , Irwansyah Irwansyah
Published: March 2022

This study discusses the partial and simultaneous influence between Earning Per Share (EPS), Devidend Per Share (DPS) and Price Earning Ratio (PER) on Stock Prices in PT. Bank Rakyat Indonesia, Tbk for the 2015-2019 Period. This research is a quantitative method research with asosiatif kausal research type. Annual report of PT. Bank Rakyat Indonesia is the population on this research, The sample used was the PT. Bank Rakyat Indonesia, tbk financial statements 2015-2019 period with the sampling technique used was nonprobability sampling by purposive sampling. The type of data used in this study is secondary data that contains PT. Bank Rakyat Indonesia, tbk financial reports 2015-2019 period. The technique of collecting data by literature study and documentation. Data analysis techniques in this study used multiple regression analysis. The results of the study prove that Earning Per Share (EPS) is partially insignificant to the share price related to the significance level of 0,068 > 0,05 with an effective contribution value of -69.5%. Devidend Per Share (DPS) is partially has no significant effect on the share price related to the significance level of 0,163 > 0.05 with an effective contribution value of 9.8%.  and Price Earning Ratio (PER) is partially significant toward the share price related to the significance level of 0,046 ≤ 0.05 with an effective contribution value of 159.4%.  simultaneously Earning Per Share (EPS), Devidend Per Share (DPS) and Price Earning Ratio (PER) have insignificant effect on stock prices with a sig value of 0,068 > 0,05. Magnitude of influence of 99,7%.  Keyword: Earning Per Share (EPS), Devidend Per Share (DPS) and Price Earning Ratio (PER) and stock prices
Pengaruh Kualitas Layanan Produk dan Harga Terhadap Kepuasan Pelanggan Pengguna XL di Kota Banjarmasin (Studi Pada Pengguna Paket Data Internet)
Authors: Allana Muhammad Najwan Ridho , Hidayati Noor , Khairussalam Khairussalam
Published: March 2022

The purpose of this research is to find out and examine the effect partially and simultaneously Service Quality (X1) and Price (X2) on Customer Satisfaction (Y) XL users in Banjarmasin city. This study uses a quantitative approach with an associative type. The population in the study were all XL 4G users or consumers in Banjarmasin City. The total sample was 120 people using accidental sampling. The data collection technique was using a questionnaire and the data analysis technique used was Multiple Linear Regression. The research results prove that Service Quality (X1) partially has a significant positive effect on Customer Satisfaction (Y) with the Sig. 0.037 <0.05. And Price (X2) partially has a significant positive effect on Customer Satisfaction (Y) with the value of Sig. 0.000 <0.05. The test results simultaneously show that service quality (X1) and price (X2) have a significant positive effect on customer satisfaction (Y) with the Sig. 0.000 <0.05. Keywords : Service Quality, Price, and Customer Satisfaction
Effect and optimization of incorporation of nano-SiO2 into cement-based materials – a review
Authors: Al-Hagri Mohammed Gamal , Döndüren Mahmud Sami
Published: March 2022

Incorporation of nanomaterials into cement-based materials has great potentials to improve their performance to great levels and to produce construction materials with superior and unique properties. Various nanoparticles have been utilized in cementitious composites to improve their properties. This paper provides a detailed review about the effect of the most widely incorporated nanomaterial into cement-based materials, namely nano-silica, on different on properties of cement-based materials. The investigated properties are mechanical properties (compressive strength, split tensile strength and flexural strength), durability parameters (permeability, freeze and thaw resistance, high temperature resistance, fire resistance and sulfate attack resistance) and microstructural properties of mortar and concrete. The cost effectiveness of use of nano-silica in cement-based materials is also discussed. The optimum replacement percentage of cement with this nanomaterial to improve the performance of mortar and concrete is also investigated. The investigation showed that nano-silica has the ability to enhance the mechanical properties, durability and microstructural properties of concrete and mortar to a remarkable level. It also showed that the optimum content of nano-silica in concrete and mortar is 1.0-4.0% by weight of binder materials.
Wind loads on girder bridges
Authors: Zdravkov Lyubomir A.
Published: March 2022

Bridges are facilities that are in exploitation outdoor. Often the wind is the leading horizontal force in the transverse direction. Therefore the bridges have received the due attention in the standards for wind loading. Unfortunately, in all available standards for wind load on the bridges, one, summarized value of the aerodynamic coefficient is indicated. It is related to the entire cross-section of the facility. There is no differentiation for the individual longitudinal girders and/or roadway. Information about the specific wind pressure on each of the bridge’s element is required for the correct design of their supporting systems, whether they are framed or braced type. To fill this gap, the author has built several models of bridges with longitudinal girders, using a Computational Fluid Dynamics (CFD) analysis. Through them he determined the values of the aerodynamic coefficients for each of the bridge girders under the roadway and the cross-section of the bridge as a whole. Conclusions are summarized and the results clearly show the values of the aerodynamic coefficients for the whole section of the bridge are with 50-60% lower than the ones reported for the windward girder.
Structural evaluation of unitized curtain wall systems by using inter-story drift test
Authors: Dogru Selcuk , Cakir Ferit , Akbas Bulent
Published: March 2022

A curtain wall enhances the aesthetic appeal of a building and protects it from harmful environmental conditions. As one of the most significant façade curtain walls, Unitized Curtain Wall Systems (UCWS) are constructed concurrently with the construction of the structural framing system. Because of their lightness, ease of application, functionality, and various design possibilities, UCWSs are frequently used as exterior panels on high-rise buildings. UCWSs must be designed to resist external loads such as wind and seismic load during their lifetime. A structural performance evaluation of the UCWSs is therefore one of the most important criteria for their design. American Architectural Manufacturers Association (AAMA) suggests conducting a full-scale test on a mock-up to determine the structural performance in accordance with AAMA 501.4. In this study, an inter-story drift test was performed according to the AAMA 501.4 standard on a two-story UCWS system, comprised of six panels 1430.8 mm wide and 4215 mm high. The structural behavior of the system was assessed using horizontal and vertical displacement meters that were placed at various points in the system. In addition, a simplified numerical model of the system was prepared and experimental studies were supported by finite element analysis.
Viewing Japanese People's Cognitive Concept From Japanese Proverbs —— Taking "View of Nature" and "View of Emotion" as Examples
Authors: Xie Yuyang
Published: March 2022

Proverbs are a vital component of Japanese language culture, and their breadth encompasses all facets of human existence. Proverbs are the result of years of understanding growth, the crystallization of life experience, and a source of information. Proverbs are ingrained in the Japanese people and culture. This article uses the study objects "view of nature" and "view of emotion" to integrate language culture theory with information about natural things and family culture in order to help readers better comprehend the Japanese cognitive notion.
Non-Commutative Key Exchange Protocol
Authors: Lizama-Pérez Luis Adrián , Romero José Mauricio López
Published: March 2022

We introduce a novel key exchange protocol based on non-commutative matrix multiplication defined in $\mathbb{F}_p^{n \times n}$. The security of our method does not rely on computational problems as integer factorization or discrete logarithm whose difficulty is conjectured. We show that the public, secret and channel keys become indistinguishable to the eavesdropper under matrix multiplication. Remarkably, for achieving a 512-bit security level, the public key is 1024 bits and the private key is 768 bits, making them the smallest keys among post-quantum key exchange algorithms. Also, we discuss how to achieve key authentication, interdomain certification and Perfect Forward Secrecy (PFS). Therefore, Lizama's algorithm becomes a promising candidate to establish shared keys and secret communication between (IoT) devices in the quantum era.
Estimating the Best Exponent of the Modified Universal Soil Loss Equation and Regionalizing the Modified Universal Soil Loss Equation Under Hydro-Climatic Condition of Ethiopia
Authors: Tsige Manaye Getu , Malcherek Andreas , Seleshi Yilma
Published: March 2022

Soil erosion and sediment transport are quite complex processes as they depend on physical, biological, mechanical, and chemical processes within a particular catchment. Therefore, it is highly essential to better explain engaged physical processes and means of accounting for site-specific conditions, for soil loss and sediment yield estimation. This paper mainly focuses on physical explanations behind soil erosion and common soil erosion models like Universal or Revised Universal Soil Loss Equation(USLE/RUSLE) and Modified Universal Soil Loss Equation(MUSLE). Based on the physical explanations and overall limitations, the MUSLE is selected for the application of sediment yield estimation. The main objective of this paper is to estimate the best exponent of the MUSLE, and to estimate the best combination of the exponent and topographic factor of the MUSLE under hydro-climatic conditions of Ethiopia. For the sake of calibration procedure, the main parameters of the MUSLE which directly affect soil erosion process such as cover, conservation practice, soil erodibility, and topographic factors are estimated based on the past experiences from literature and comparative approaches, whereas the other parameters which do not directly affect the erosion process or which have no any physical meaning (i.e coefficient a and exponent b) are estimated through calibration. It is verified that the best exponent of the MUSLE is 1 irrespective of the topographic factor, which results in the maximum performance of the MUSLE (i.e approximately 100\%). For the best combination of the exponent and topographic factor, the performance of the MUSLE is greater than or equal to 80\% for all four watersheds under our consideration, we expect the same for other watersheds of Ethiopia.
Desynchronization of Clocks in Rigid Acceleration and Gravitational Redshift
Authors: Şahin İnanç
Published: March 2022

In this paper, we examine the prediction of the theory of relativity for the desynchronization of accelerating clocks separated by a proper distance l. We adopt the approach of Larmor-Lorentz-Poincaré-Bell to relativity and derive clock desynchronization as a result of an acceleration procedure based on two basic assumptions. Such an approach exhausts the freedom of Einstein's approach that allows for different clock synchronizations. We show that contrary to expectations, as a result of acceleration, the rear clock actually shifted backwards with respect to the front clock according to an inertial observer. However, due to Einstein’s equivalence principle the accelerating observer feels a gravitational field and observes that the rear clock undergoes a gravitational redshift relative to the front clock. This gravitational time shift is larger than the time shift for the acceleration and the difference is exactly equal to the special relativistic time shift. Eventually, we arrive at the conclusion that Einstein’s equivalence principle and gravitational redshift is necessary to explain special relativistic clock desynchronization.
The Collective Mind: An Experimental Analysis of Imitation and Self‑organization in Humans
Authors: Olarewaju Emmanuel
Published: March 2022

I present an experimental paradigm to explore the interpersonal dynamics generating a collective mind. I hypothesized that collective organization is based on dual interpersonal modes: (1) symmetrical and (2) anti‑symmetrical. I specified the geometric topology of these modes by detecting the spatiotemporal patterns that embed cooperative agents in a three‑dimensional matrix. I found that the symmetrical mode is executed automatically and without guidance. Conversely, the anti‑symmetrical mode required explicit direction and recruited attention for execution. I demonstrate that self‑other mirror‑symmetry stabilized group dynamics, enabled fast and efficient symmetrical imitation that optimized information transmission, whereas anti‑symmetrical imitation was comparatively slow, inefficient, and unstable. I determined that the anti‑symmetrical mode spontaneously transitioned to the symmetrical mode under perturbations. Crucially, this renormalization mechanism never transitioned from symmetrical to anti‑symmetrical. These self-organizing dynamics speak to interpersonal symmetry‑breaking. In the present work, spontaneous group choice mandated that agents synchronize cooperative cycles in symmetrical space under internal or external perturbations. I provide examples to illustrate that this self-regulating pullback attractor manifests in invertebrates and vertebrates alike. I conclude by suggesting that inter‑agent symmetry provides the social stability manifold through which attention-driven interactions enable intrapersonal and interpersonal change.
Multi-Model Learning to Detect Twitter Hate Speech
Authors: Patil Dharmaraj , Pattewar Tareek
Published: March 2022

Users on the social networking platform have the freedom to express themselves freely. Towards the same time, this has created a forum for disagreement and hate directed at someone, society, racism, sexual orientation, and so on. Identifying hate online is a challenging task. Researchers from all around the world have contributed major methods for detecting hate speech, but owing to the issue's complexity, there are still many unresolved issues. In this research, we offer a multi-model learning strategy for detecting hate speech on Twitter. We utilised the Kaggle TwitterHate dataset, which had 31962 tweets categorised as binary hate or non-hate, to evaluate our technique. The suggested method is tested using commonly used machine learning classifiers with multi-model technique. Using TF-IDF features, we acquired detection results of 96.29 %, precision of 96%, recall of 96%, and f1-score of 96%.
Looking Forward: The Role of Academic Researchers in Building Sustainable Wastewater Surveillance Programs
Authors: Hoar Catherine , McClary-Gutierrez Jill , Bivins Aaron , Wolfe Marlene , Bibby Kyle , Silverman Andrea , McLellan Sandra
Published: March 2022

Background: In the span of just two years, tracking the COVID-19 pandemic through wastewater surveillance has advanced from early reports of successful SARS-CoV-2 RNA detection in untreated wastewater to implementation of programs in at least 60 countries. Early wastewater monitoring efforts primarily originated in research laboratories and are now transitioning into more formal surveillance programs run in commercial and public health laboratories. A major challenge in this progression has been to simultaneously optimize methods and build scientific consensus while implementing surveillance programs, particularly during the rapidly changing landscape of the pandemic. Translating wastewater surveillance results for effective use by public health agencies also remains a key objective for the field. Objectives: We examine the evolution of wastewater surveillance to identify model collaborations and effective partnerships that have created rapid and sustained success. We propose needed areas of research and key roles academic researchers can play in the framework of wastewater surveillance to aid in the transition of early monitoring efforts to more formalized programs within the public health system. Discussion: Wastewater surveillance has rapidly developed as a public health tool Clinical testing programs are ramping down and home testing is on the rise, making wastewater monitoring important for future surveillance of COVID-19. Our experience in initiating and implementing wastewater surveillance programs in the United States has allowed us to reflect on key barriers and organizational challenges and draw useful lessons. As wastewater surveillance programs are formalized, the working relationships developed between academic researchers, commercial and public health laboratories, and data users should continue and should promote knowledge co-development. While wastewater surveillance has demonstrated utility for tracking COVID-19, there remain technical challenges and open scientific questions that researchers are equipped to address, which will contribute to building robust surveillance programs that provide public health practitioners with new insights into population health.
Enacting Economic Resilience: A Synthesis of Economic and Communication Frameworks
Authors: Betts Timothy , Buzzanell Patrice M
Published: March 2022

This work reviews three frameworks for responding to economic disruption: risk mitigation, systemic recovery, and economic resilience. Specifically, by reviewing extant literature in economics, communication, and other disciplines, we argue that current approaches to understanding resilience in economics largely fail to address ongoing and emergent disruptions to the economic and social world. In response to these issues, we work to synthesize economic frameworks and the communication theory of resilience to forward a new way of examining the overlapping questions of economic resilience related to metatheoretical commitments, analytic contexts, and implications for theory, method, and practice.
Gambaran Ultrasonografi Kelainan Endometrium pada Penderita Kanker Payudara yang Mendapat Terapi Hormonal di Rumah Sakit Wahidin Sudirohusodo
Authors: Thayyib Hijriah , Muis Mirna , Murtala Bachtiar
Published: March 2022

Pendahuluan: Penelitian ini bertujuan untuk menilai gambaran ultrasonografi kelainan endometrium pada penderita kanker payudara yang mendapat terapi hormonal di Rumah Sakit Wahidin Sudirohusodo. Metode:  Penelitian ini dilaksanakan di Rumah Sakit Umum Pemerintah Wahidin Sudirohusodo Makassar mulai bulan Januari sampai bulan Mei 2020. Sampel sebanyak 66 pasien yang telah mendapat terapi hormonal minimal 6 bulan berturut-turut dan dilakukan pemeriksaan ultrasonografi transvaginal. Metode analisis yang dilakukan adalah Uji Chi Square/Uji Fisher dan Uji T Independen. Hasil:   Pada penelitian ini, rentang usia terbanyak pasien kanker payudara adalah antara 41 – 50 tahun. Dari 66 pasien yang diteliti, terdapat 34 pasien yang premenopause dan 32 pasien yang menopause. Terdapat 46 pasien yang mendapat terapi Tamoxifen, 20 pasien yang mendapat terapi Aromatase inhibitor. Kesimpulan: Hasil penelitian menunjukkan tidak terdapat hubungan yang bermakna antara penebalan endometrium pada pemeriksaan ultrasonografi transvaginal dengan pemberian terapi hormonal pada penderita kanker payudara dengan nilai p=0,232. Terdapat hubungan bermakna antara status menstruasi dengan penebalan endometrium pada penderita kanker payudara yang mendapat terapi hormonal dengan nilai p=0,002. Terdapat hubungan bermakna antara Indeks Massa Tubuh (IMT) dengan penebalan endometrium pada penderita kanker payudara yang mendapat terapi hormonal dengan nilai p=0,037. Tidak terdapat hubungan bermakna antara penggunaan kontrasepsi hormonal terhadap penebalan endometrium dengan nilai p=0,946. Tidak terdapat hubungan yang bermakna antara nullipara dengan kejadian penebalan endometrium dengan nilai p=0,256
PENINGKATAN DAYA DUKUNG TANAH EKSPANSIF MENGGUNAKAN LIMBAH GYPSUM DAN SERBUK KACA
Authors: Mudhakir Ibnu , Nurhidayati Aryanti , Suprimurtiono Eko
Published: March 2022

Tanah lempung ekspansif merupakan tanah yang banyak mengandung mineral
montmorillonite dan illite. Tanah ini memiliki sifat plastisitas yang tinggi, daya dukung yang rendah, dan juga kuat geser yang rendah. Salah satu daerah di Indonesia yang memiliki kondisi tanah ekspansif adalah di daerah Soko, Ngawi, Jawa Timur. Kepekaan mineral ini terhadap air berpengaruh terhadap rendahnya daya dukung tanah. Parameter tanah yang diperlukan untuk mengetahui daya dukung tanah pada umumnya dinyatakan dengan besarnya nilai kuat tekan dan CBR (California Bearing Ratio). Daya dukung tanah yang rendah membuat beban yang dipikul oleh tanah juga rendah, sehingga ketika terjadi penambahan beban akan terjadi penurun tanah. Dalam memperbaiki struktur tanah harus memperhatikan aspek lingkungan, salah satunya adalah mengenai pemanfaatan limbah yang tidak terpakai, yaitu limbah gypsum dan limbah kaca yang banyak mengandung mineral yang dapat digunakan untuk menstabilkan tanah. Dari hasil penelitian didapatkan Nilai CBR maksimum pada variasi 10% limbah gypsum dengan 8% serbuk kaca. Dimana nilai CBR unsoaked pada tanah asli sebesar 7,875% sedangkan pada CBR soaked sebesar 1,975%, setelah dilakukan stabilisasi dengan limbah gypsum dan serbuk kaca mengalami perubahan nilai CBR unsoaked menjadi 38,327% dan CBR
soaked menjadi 6,252%.
Perceived Message Effectiveness of the Meatless Monday Campaign: An Experiment With US Adults
Authors: Rayala Hannah-Therese , Rebolledo Natalia , Hall Marissa G. , Taillie Lindsey Smith
Published: March 2022

Given the negative health and environmental impacts of red meat consumption, reducing red meat intake in the United States is important for both human and planetary well-being. To experimentally evaluate the impact of health-focused and environment-focused messages from the Meatless Monday campaign, we conducted an online randomized experiment among US adults aged 18 years or older (n = 1244). Compared with control messages, health-focused and environment-focused Meatless Monday messages led to significantly higher perceived message effectiveness and increased intention to reduce meat consumption. (Am J Public Health. 2022;112(5):724–727. https://doi.org/10.2105/AJPH.2022.306766 )
Risk of Revision After Hip Fracture Fixation Using DePuy Synthes Trochanteric Fixation Nail or Trochanteric Fixation Nail Advanced
Authors: Goodnough L. Henry , Chang Richard N. , Fasig Brian H. , Prentice Heather A. , Paxton Elizabeth W. , Diekmann Glenn R. , Jackman James M. , Okike Kanu , Fang Andrew S.
Published: March 2022

Background:

Prior reports of the DePuy Synthes Trochanteric Fixation Nail Advanced (TFNA) revealed a potential mode of fatigue failure at the proximal screw aperture following fixation of extracapsular hip fractures. We sought to compare the revision risk between the TFNA and its prior-generation forebear, the Trochanteric Fixation Nail (TFN).

Methods:

A retrospective cohort study was performed using data from a U.S. integrated health-care system’s hip fracture registry. The study sample comprised patients who underwent cephalomedullary nail fixation for hip fracture with a TFN (n = 4,007) or TFNA (n = 3,972) from 2014 to 2019. We evaluated the charts and radiographs for patients who underwent any revision. Multivariable Cox regression was used to evaluate the risk of revision related to the index fracture.

Results:

At the 3-year follow-up, the cumulative probability of revision related to the index fracture was 1.8% for the TFN and 1.9% for the TFNA. After adjustment for covariates, no difference was observed in revision risk (hazard ratio [HR], 1.18 [95% confidence interval (CI), 0.80 to 1.75]; p = 0.40) for the TFNA compared with the TFN. The TFNA was associated with a higher risk of revision for nonunion than the TFN (HR, 1.86 [95% CI, 1.11 to 3.12]; p = 0.018). At the 3-year follow-up, implant breakage was 0.06% for the TFN and 0.2% for the TFNA; with regard to aperture failures related to the index fracture, there were 1 failure for the TFN group and 3 failures for the TFNA group.

Conclusions:

In a large cohort from a U.S. hip fracture registry, the TFNA had an overall revision rate that was similar to that of the earlier TFN, with implant breakage being a rare revision reason for both groups. Chart and radiographic review found that the TFNA was associated with a higher risk of revision for nonunion.

Level of Evidence:

TherapeuticLevel III. See Instructions for Authors for a complete description of levels of evidence.
Food Insecurity among Lesbian, Gay, Bisexual, and Transgender Adults During the COVID-19 Pandemic in the United States, July-October 2021
Authors: Singh Gopal K , Lee Hyunjung , Azuine Romuladus E.
Published: March 2022

Background: The lesbian, gay, bisexual, and transgender (LGBT) population makes up approximately 6% of the total United States (US) population. Levels and patterns of food insecurity in the LGBT population during the COVID-19 pandemic compared with the general population are unknown. This study examines prevalence and sociodemographic correlates of food insecurity among LGBT and straight/heterosexual adults in the US.
Methods: Using the US Census Bureau’s Household Pulse Survey from July to October 2021 (N=372,542), differentials in food insecurity according to LGBT status were analyzed by multivariate logistic regression.
Results: The prevalence of food insecurity during the pandemic was 25.6% for transgender adults aged ≥18, significantly higher than that for lesbian/gay adults (11.6%), bisexual adults (13.5%), and straight/heterosexual adults (7.8%). Compared with the straight/heterosexual population, LGBT adults had lower education and income levels and higher unemployment and were more likely to be non-Hispanic White and single. Transgender adults were particularly disadvantaged with respect to socioeconomic status, job loss, and lack of health insurance. After controlling for socioeconomic and demographic covariates, lesbian/gay, bisexual, and transgender adults experienced, respectively, 36%, 35%, and 157% higher odds of food insecurity than straight/heterosexual adults. Black/African American, Hispanic, and mixed-race/ethnicity, lower education and income, lack of homeownership, divorce/separation, lack of health insurance, and recent job loss were significant predictors of food insecurity among LGBT adults. Inequalities in food insecurity by LGBT status were similar in large metropolitan areas.
Conclusions and Implication for Translation: Significant disparities in food insecurity exist withLGBT adults, particularly transgender adults, at substantially increased risk of experiencing food insecurity, economic hardship, and social disadvantage during the pandemic and likely in greater need of social and public assistance. Health policies aimed at improving the social and material conditions may lead to improved food security and health outcomes among LGBT adults and the general US population.
 
Copyright © 2022 Singh et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Saúde baseada em valor: será que isso vai dar certo?
Authors: Follador Wilson
Published: March 2022

Artigo de opinião
Censo das organizações sociais de saúde brasileiras: levantamento e caracterização
Authors: Barcelos Catarina , Andrade Mônica , Botega Laura , Malik Ana Maria
Published: March 2022

Objetivo: Identificar e caracterizar os estabelecimentos geridos por Organizações Sociais de Saúde (OSSs) no Brasil. Métodos: A identificação desses estabelecimentos foi realizada mediante quatro procedimentos de busca por meio de pesquisa primária nos sítios das secretarias de saúde dos estados e dos municípios e consulta nos sítios das OSS e na Pesquisa de Informações Básicas Municipais do Instituto Brasileiro de Geografia e Estatística (IBGE), em 2018. Foi realizada uma análise descritiva dos estabelecimentos geridos por OSS comparando com as Administrações Diretas (ADs) segundo indicadores hospitalares. Resultados: Os estabelecimentos geridos por OSSs estão concentrados principalmente no Sudeste e no Sul do país, e 69% desses estabelecimentos são geridos por 20 OSSs. As OSSs estão mais presentes em hospitais-dia, seguidos de prontos atendimentos e de hospitais. A caracterização dos hospitais mostrou que aqueles administrados por OSSs apresentam melhor desempenho; contudo as diferenças diminuem à medida que se aumenta o porte do serviço. Os hospitais de maior porte apresentaram melhor desempenho em relação aos demais e é onde está concentrada a maior proporção de OSSs entre os hospitais. Conclusão: Este é o primeiro trabalho que faz uma identificação das OSSs em nível nacional. Essa listagem das OSSs é um instrumento importante de planejamento, monitoramento e organização da estrutura de oferta de serviços no Sistema Único de Saúde (SUS). Os resultados encontrados demonstram a necessidade de organização de uma base de dados administrativa que permita um acompanhamento do desempenho dos estabelecimentos no tempo.
Análise dos modelos de pagamento aplicados ao financiamento federal na perspectiva do Sistema Único de Saúde
Authors: Macêdo Everton , Silva Anderson José , Cavalcanti Ivanessa , Pedreira Mariana , Lima Célia , Vieira Aliane , Cruz Rebeca
Published: March 2022

Objetivo: Este estudo tem por objetivo identificar os modelos de pagamento existentes no Sistema Único de Saúde referentes aos repasses federais para a Atenção Primária à Saúde (APS) e a Atenção Especializada à Saúde. Métodos: Foi realizado um estudo quantitativo e analítico, desenvolvido em três etapas: levantamento de todos os tipos de repasse da União; classificação de cada categoria de repasse segundo os tipos de modelos de pagamentos; e mensuração da participação de cada modelo de pagamento, de acordo com os componentes de financiamento analisados, em relação aos valores líquidos repassados. Resultados: Os repasses federais foram classificados em sete modelos de pagamentos. Para a APS, em 2020, foram apurados R$ 21,7 bilhões, aproximadamente, incluindo os recursos destinados para a pandemia, e R$ 20,9 bilhões, sem considerar os recursos para enfrentamento da pandemia de COVID-19. Mais de 50% dos valores empregados foram classificados como capitação, em ambos os casos. Para a Atenção Especializada à Saúde, em 2019, foram computados em torno de R$ 48,5 bilhões e, em 2020, acima de R$ 49,2 bilhões. Para os dois anos, mais de 70% dos recursos foram destinados a pagamentos por procedimento. Conclusões: Este estudo permitiu a ampliação do conhecimento sobre a alocação dos recursos referentes aos repasses da União para estados, Distrito Federal e municípios. Como os modelos de pagamentos estão relacionados com a produtividade, acesso e qualidade do serviço de saúde, conhecer as formas de pagamento e identificar a mais adequada para cada situação contribui para o alcance das metas e para a mitigação de eventuais perdas de eficiência nos sistemas de saúde.
Oportunidades e desafios da saúde baseada em valor: como o Brasil pode aprender com a experiência dos Estados Unidos
Authors: Abicalaffe César Luiz , Schafer Jeremy
Published: March 2022

O movimento em direção à saúde baseada em valor é uma evolução que ocorre em muitas nações do mundo. O crescimento populacional, o aumento da expectativa de vida e o custo crescente com uma saúde de alta tecnologia exigem que os pagadores públicos e privados de todo o mundo criem novas maneiras de garantir que os gastos com saúde sejam feitos nas intervenções de maior impacto. Nesse ponto de vista, apresentamos o caso da transformação da saúde baseada em valor, que está atualmente em sua infância no Brasil. O Brasil possui pagadores públicos e privados e ainda paga os serviços na maioria das vezes no modelo de pagamento por procedimento. Comparamos isso com a experiência recente nos Estados Unidos, onde a saúde baseada em valor está, de maneira lenta, mas segura, se tornando a norma. O Sistema de Saúde Brasileiro tem muitas oportunidades de aprender com a mudança ocorrida nos EUA para um modelo de saúde baseado em valor – incluindo o desenvolvimento de medidas de qualidade, a transição para pagamento baseado em valor e a melhoria dos dados para avaliar o desempenho nos sistemas de saúde brasileiros. As indústrias de produtos farmacêuticos no Brasil também podem desempenhar um papel, com acordos baseados em valor e parcerias com pagadores. Cada nação seguirá seu próprio caminho para uma saúde baseada em valor, mas a oportunidade de aprender um com o outro possibilita melhores chances de sucesso.
A Century of Dislocated Time: Time Travel, Magic and the Search for Self
Authors: Scott Carole
Published: March 2022

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A Little Masterpiece: Patricia Wrightson's A Little Fear
Authors: Murray John
Published: March 2022

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Experimental and optimization studies of Ultrasonic assisted friction stir weldments of AA2014-T651 using Graph theory
Authors: Lam Suvarna Raju , Venu Borigorla
Published: March 2022

Joining of Al-Cu based alloys such as AA2014-T651 is very difficult by fusion welding techniques due to liquefaction and solidification cracks. Therefore, solid state welding namely Friction Stir Welding (FSW) is most suitable to join these alloys. The main objective of this work is to identify the most influenced process parameters such as rotation speed of the tool, and tool traverse speed and their levels for fabricating the weldments by FSW process with using ultrasonic vibrations (UAFSW). A set of experiments were carried out using the plain cylindrical and taper threaded cylindrical tool pin profile at different levels of process parameters and experimental results were collected. A graph theory and utility concept was proposed and found an optimal working condition for better weldment properties. The UAFSW process enhanced the AA2014-T651 weldment mechanical characteristics at 1100 rev/min of tool rotation speed, and 40 mm/min of tool traverse speed. The tensile strength, yield strength, percentage of elongation, impact strength and micro hardness were found to be 431.69 MPa, 307.47 MPa, 11.66%, 8.32 J, and 139 HV respectively at optimal working condition. The weld joint obtained using a taper threaded tool pin profiled with ultrasonic vibration exhibits 95% joint efficiency compared to the weldments made by plain cylindrical taper tool pin profile with ultrasonic vibration. The measured characteristics have been correlated with microstructure and fracture features. The optimized responses were verified by the validation test.
HOXA11-AS1 promotes PD-L1 mediated immune escape and metastasis of hypopharyngeal carcinoma by facilitating the association of PTBP1 with FOSL1
Authors: Zhou Zheng , Liu Qian , Zhang Gehou , Mohammed Diab , Amadou Sani , Tan Guolin , Zhang Xiaowei
Published: March 2022

Background
The metastatic characteristics of hypopharyngeal squamous cell carcinoma (HSCC) led to many diagnostic and therapeutic challenges. The identification of functional long non-coding RNAs (lncRNAs) would contribute to investigate effective strategies for the diagnosis and treatment of HSCC.
Methods
RT-qPCR, western blot, immunohistochemistry and immunofluorescence assay were used to detect the related gene expression. Flow cytometry was used to measure the percentage of CD8+ and CD4+ T cells. CCK-8 and transwell assays were performed to analyze the functional role of HOXA11-AS1. The targeted relationship of FOSL1/PD-L1 promoter was measured by ChIP and dual-luciferase reporter assays. RNA pull-down and RIP assays were used to measure the interaction between HOXA11-AS1, FOSL1 and PTBP1. Tumor xenograft study was used to analyze the function of HOXA11-AS1 in vivo.
Results
HOXA11-AS1, PD-L1 and FOSL1 were up-regulated in HSCC, and HOXA11-AS1 was positively correlated with PD-L1. HOXA11-AS1 knockdown upregulated CD8 + T cells and the concentration of IFN-γ, while decreased the proliferation, migration and invasion of HSCC cells. FOSL1 bound to PD-L1 promoter and increased its expression. HOXA11-AS1 enhanced the stability of FOSL1 mRNA by binding to PTBP1. Overexpression of HOXA11-AS1 or PTBP1 increased the expression of FOSL1 and PD-L1. Knockdown of PD-L1 arrested the inhibiting function of HOXA11-AS1 overexpression on CD8+ T cells content. Knockdown of HOXA11-AS1 inhibited the immune escape and metastasis through regulating PD-L1 by down-regulating FOSL1 in vivo.
Conclusion
HOXA11-AS1 promoted PD-L1 expression through up-regulating FOSL1 levels by PTBP1, thereby facilitating the immune escape, proliferation and metastasis of HSCC cells.
Effect of Different Decellularization Protocols on Reendothelialization with Human Cells for a Perfused Renal Organoid of the Rat
Authors: Sauter Johannes , Degenhardt Hannes , Tuebel Jutta , Foehr Peter , Knoeckel Philipp , Florian Kira , Charitou Fiona , Burgkart Rainer , Schmitt Andreas
Published: March 2022

BackgroundScaffolds for tissue engineering can be received by whole organ decellularization while maintaining the site-specific extracellular matrix and the vascular tree. One among other decellularization techniques is the perfusion-based method using specific agents e.g. SDS for the elimination of cellular components. While SDS can disrupt the composition of the extracellular matrix and impair the adherence and growth of site-specific cells there are indications that xenogeneic cell types may benefit from protein denaturation by using higher detergent concentrations. The aim of this work is to investigate the effect of two different SDS-concentrations (i.e. 0.66% and 3%) on the ability of human endothelial cells to adhere and proliferate in an acellular rat kidney scaffold.Material and methodsAcellular rat kidney scaffold was obtained by perfusion-based decellularization through the renal artery using a standardized protocol including SDS at concentrations of 0.66% or 3%. Subsequently cell seeding was performed with human immortalized endothelial cells EA.hy 926 via the renal artery. Recellularized kidneys were harvested after five days of pressure-controlled dynamic culture followed sectioning, histochemical and immunohistochemical staining as well as semiquantitative analysis.ResultsEfficacy of decellularization was verified by absence of cellular components as well as preservation of ultrastructure and adhesive proteins of the extracellular matrix. In semiquantitative analysis of recellularization, cell count after five days of dynamic culture more than doubled when using the gentle decellularization protocol with a concentration of SDS at 0.66% compared to 3%. Detectable cells maintained their endothelial phenotype and presented proliferative behavior while only a negligible fraction underwent apoptosis.ConclusionRecellularization of acellular kidney scaffold with endothelial cells EA.hy 926 seeded through the renal artery benefits from gentle decellularization procedure. Because of that, decellularization with a SDS concentration at 0.66% should be preferred in further studies and coculture experiments.
Development of a screening algorithm for borderline personality disorder using electronic health records
Authors: Wang Fei , Zang Chengxi , Goodman Marianne , Zhu Zheng , Yang Lulu , Yin Ziwei , Tamas Zsuzsanna , Sharma Vikas_Mohan , Shao Nan
Published: March 2022

Borderline personality disorder (BoPD or BPD) is highly prevalent and characterized by reactive moods, impulsivity, behavioral dysregulation, and distorted self-image. Yet the BoPD diagnosis is underutilized and patients with BoPD are frequently misdiagnosed resulting in lost opportunities for appropriate treatment. Automated screening of electronic health records (EHRs) is one potential strategy to help identify possible BoPD patients who are otherwise undiagnosed. We present the development and analytical validation of a BoPD screening algorithm based on routinely collected and structured EHRs. This algorithm integrates rule-based selection and machine learning (ML) in a two-step framework by first selecting potential patients based on the presence of comorbidities and characteristics commonly associated with BoPD, and then predicting whether the patients most likely have BoPD. Leveraging a large-scale US-based de-identified EHR database and our clinical expert’s rating of two random samples of patient EHRs, results show that our screening algorithm has a high consistency with our clinical expert’s ratings, with area under the receiver operating characteristic (AUROC) 0.837 [95% confidence interval (CI) 0.778-0.892], positive predictive value 0.717 (95% CI 0.583-0.836), accuracy 0.820 (95% CI 0.768-0.873), sensitivity 0.541 (95% CI 0.417-0.667) and specificity 0.922 (95% CI 0.880-0.960). Our aim is, to provide an additional resource to facilitate clinical decision making and promote the development of digital medicine.
The Benefits of Short-Term Preoperative Nutritional Intervention for Cleft Surgery Eligibility
Authors: Mikhail Shady , Chattopadhyay Lily , DiBona Melissa , Steppling Charlotte , Kwadio Dede , Ramamonjisoa Anjaramamy , Gallardo Wendy , Almendarez Fatima , Sylvester Beau , Rosales Samanta , Nthalika Ibrahim , Collier Zachary , III William Magee , Auslander Allyn
Published: March 2022

Background: Children with orofacial clefts (OFCs) are highly susceptible to malnutrition, with severe malnutrition restricting their eligibility to surgery. Ready-to-use therapeutic foods (RUTF) are an effective treatment for children with malnutrition; however, the effectiveness of short-term preoperative nutritional supplementation in in patients with OFCs has not been demonstrated. We studied the effectiveness of RUTF in patients with OFCs prior to surgery. Methods: A cohort of patients with OFC from Ghana, Honduras, Malawi, Madagascar, Nicaragua, and Venezuela was followed by Operation Smile from June 2017 to January 2020. These patients were enrolled in a nutrition program that provided RUTF and tracked age, weight, and length/height at each visit. A WHO Weight-for-Length (WLZ) or Weight-for-Height (WHZ) Z-score was calculated for each patient to longitudinally track malnutrition status. Patients were tracked to being sufficiently nourished (Z >= -1) with a secondary outcome of receiving surgery. Results: A total of 556 patients were recruited between June 2017 and January 2020. Initially, 28.2% (N=157) were diagnosed with severe, 21.0% (n=117) with moderate, and 50.7% (n=282) with mild malnutrition. 324 (58.3%) patients presented for at least one return visit. Of the 324 patients who returned, 207 (63.7%) reached optimal nutrition status– 32 (15.5%) with initial severe, 30 (14.5%) with moderate, and 145 (70.0%) with mild malnutrition. By the second visit, the mean z-score increased significantly from -2.5 (moderate malnutrition) to -1.7 (mild malnutrition) (p<0·001). The mean time to attain Z >= -1 was 6 weeks with a range of 1 to 103 weeks. There was a significant difference by country in the proportion of patients who improved (p<0.001). Conclusion: Malnutrition prevents many children with OFC from receiving surgical care even when provided for free creating a larger disparity in access to surgery. In an average of 6 weeks and approximately $25 USD per patient, RUTF supported over 60% of patients to nutritionally healthy and eligible for surgery, making it an effective, short-term preoperative nutritional intervention. Through unique partnerships, cost-effective, large-scale nutrition programs can play a pivotal role in ensuring those at the highest risk of living with unrepaired OFC receive timely and safe surgical care.