bluuebunny/crossref_metadata_2025 huggingface dataset:
MEDEIA: O FOGO ABRASADOR DO AMOR À RUÍNA
Authors: Da Silva Aline Layane Souto , Da Silva Regina Simon
Published: September 2024

Medeia, a bruxa da Cólquida, é um importante personagem da mitologia grega, que atravessa o tempo sendo encarada como uma mulher de personalidade implacável e feitos atrozes. Retratada tanto nas ­Argonáuticas de Apolônio de Rodes (2021), quanto na Medeia de Eurípides (2010) como uma mulher de inteligência superior e saberes únicos, Medeia tem seu destino ligado a Jasão através de Eros e o amor que este imputa a princesa colca carrega a sina de dores jamais vivenciadas com traços violentos e ardentes. Com isso, este trabalho apresenta uma análise sobre a ação e manifestação de Eros na jornada de Medeia, lançando olhar sobre a simbologia do fogo – como também o campo semântico que a circunda – com o objetivo de evidenciar as violências sofridas e efetuadas por Medeia resultantes do dardo de Eros, O flagelo dos homens. A pesquisa possui caráter qualitativo e sob amparo da Literatura Comparada, pretende alinhar o estudo do mito, das simbologias e da violência centrando-se na personagem Medeia cunhada por Eurípides em sua peça homônima e por Apolônio de Rodes nas Argonáuticas. Verificou-se que a seta eleita por Eros para atingir Medeia é como o próprio deus arqueiro que ostenta um espírito sedutor, inevitável, abrasador, vingativo, violento, mortífero, etc. Assim sendo, as atitudes de Medeia também são. Enquanto está sob a maldição do amor, Medeia propaga o fogo de Eros. Contudo, quando seu amor é menosprezado e ela se vinga aniquilando todo e qualquer laço com o amado, concluímos que a maldição é quebrada e Medeia restitui sua dignidade e autocontrole.
Accumulation Radiocesium (137cs) By Plants of the Dnipro River’s Floodplain Ecosystems after Chernobyl Contamination
Authors: Oleksandr Lukash , Halina Tkaczenko , Anita Szikura , Yurii Karpenko , Oleksandr Yakovenko , Oksana Sahach , Svitlana Kyriienko , Alina Sliuta , Viktoriia Papernyk , Svitlana Pototska , Natalia Kurhaluk
Published: September 2024

The analysis of radiocesium (137Cs) accumulation by plants of forest, marsh, meadow, psamophytic, and ruderal communities in the Dnipro River floodplain (Ukraine) was carried out. The species specificity of radiocesium accumulation by plants of specific biotopes and the direct dependence of the plant accumulation coefficient on the density of biotope contamination with radionuclides were confirmed. Differences in different radiocesium accumulation by plants of different ecosystems are probably related to the fact that the bioavailability of radiocesium strongly depends on soil properties. In the analyzed statistical model, the processes of accumulation and dissipation of 137Cs are significant.
High-throughput assay for quantifying bacterial biofilm formation v1
Authors: Bowers Lisa
Published: September 2024

Biofilms are assemblages of single-celled organisms attached to a surface and encased in a sticky extracellular polymeric substance that the cells produce. Difficult to eradicate, they can have profound effects on human health and industrial processes. Studying biofilm formation and testing potential biofilm treatments or mitigation strategies requires a robust protocol for quantifying bacterial biofilms with high-throughput and reproducibility. We have developed such a protocol using readily-available staining materials and a plate reader.
Stereotaxic Injection by Iontophoresis v2
Authors: Institute for Brain Science Allen
Published: September 2024

This protocol describes the delivery of a neuronal tracer using the iontophoretic method. The surgery uses a stereotaxic system to target specific brain coordinates in the mouse. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Stereotaxic Injection by Nanoject Protocol v2
Authors: Institute for Brain Science Allen
Published: September 2024

This protocol describes the delivery of a neuronal tracer using the Nanoject II. The surgery uses a stereotaxic system to target specific brain coordinates in the mouse. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
human alpha-synuclein and aggregatedalpha-synuclein immunofluorescence staining v1
Authors: La Vitola Pietro
Published: September 2024

This protocol is designed for human alpha-synuclein staining using the MJFR1-Alexa 488 (RRID:AB_2537217) antibody and either anti-SynO2 (RRID:AB_2632701) or MJFR-14-6-4-2 (RRID:AB_2714215) antibodies. Tissue stained with this protocol include 35 μm free-floating mouse brain sections. All tissue was from mice perfused with 4% PFA.
ChAT Immunofluorescent Staining of medulla oblongata fixed sections v1
Authors: La Vitola Pietro
Published: September 2024

This protocol is designed for choline acetyltransferase (ChAT) staining using the Millipore AB144P (RRID:AB_2079751) antibody. Tissue stained with this protocol include 30μm free-floating mouse brain sections. All tissue was from mice perfused with 4% PFA.
Kahramanmaraş İlinde Akut Solunum Yolu Enfeksiyonu Ön Tanısı Olan Hastalarda Multipleks PCR Yöntemiyle Viral ve Bakteriyel Etkenlerin Sıklığının Araştırılması
Authors: Kirişci Özlem
Published: September 2024

Amaç: Bu çalışmada, Kahramanmaraş Sütçü İmam Üniversitesi Araştırma ve Uygulama Hastanesi'ne başvuran hastalarda solunum yolundan izole edilen patojenlerin dağılımı ve sıklığının belirlenmesi hedeflenmiştir.
Gereç ve yöntemler: 1 Nisan - 31 Haziran 2023 tarihleri arasında Kahramanmaraş Sütçü İmam Üniversitesi Hastanesi'ne başvuran akut solunum yolu enfeksiyonu ön tanılı hastalarının solunum yolu örnekleri, multipleks gerçek zamanlı polimeraz zincir reaksiyonu (MRT-PZR) Bio-Speedy Solunum Yolu RT-qPCR MX-24T (Bioeksen, İstanbul, Türkiye) paneli ile incelendi. Bu panel, 18 virüs ve 6 bakteriyi aynı anda tespit edebilme kapasitesine sahiptir ve örneklerin nükleik asitleri Bio-Rad Thermal Cycler CFX96 (Bio-Rad, ABD) cihazında analiz edildi.

Bulgular: Değerlendirilen 448 solunum örneğinden 168'i (%37.5) pozitif çıktı. Bu pozitif örneklerde toplam 246 patojen belirlendi; bunların 84'ü (%34.1) viral, 162'si (%65.9) bakteriyel etkenlerden oluştu. En sık rastlanan patojenler Haemophilus influenzae (n=100) ve Streptococcus pneumoniae (n=62) oldu. Pozitif örneklerin 102’sinde (%22.8) tek etken, 57’sinde (%12.7) ikili etken, 9’unda (%2) 2 ve daha fazla etken pozitifliği saptanırken, 280’inde (%62.5) etken saptanmadı. Koenfeksiyonlar arasında SARS-CoV-2'nin yalnızca 7 örnekte tespit edildiği gözlemlendi.

Sonuç: Bu çalışma, solunum yolu patojenlerinin moleküler yöntemlerle ilk kez ilimizde kapsamlı olarak değerlendirildiği bir araştırmadır. Bulgular, geniş bir patojen yelpazesi ve koenfeksiyon çeşitliliği göstermektedir. Araştırmada, geniş bir etken patojen yelpazesi belirlenmiş olup, en sık saptanan patojenler sırasıyla Haemophilus influenzae ve Streptococcus pneumoniae olarak tespit edilmiştir. MRT-PZR yönteminin hızlı ve hassas tanı sağlayarak gereksiz antibiyotik kullanımını önleyebileceği, enfeksiyon kontrolü açısından klinisyenlere yol gösterici olacaktır.
Development of a methodology for measuring the evolution of duplex stainless-steel low-temperature plasma nitrided phases expansion using confocal laser scanning microscopy
Authors: Feitosa Carlos Eduardo Alves , Cardoso Rodrigo Perito , Brunatto Silvio Francisco
Published: September 2024

Samples of duplex stainless steel SAF 2507 were low-temperature plasma nitrided to characterize separately, on the surface, the behavior of its ferrite and austenite phases in relation to two competing processes, that is, one caused by enrichment by nitrogen, resulting in possible expansion, and the other caused by the removal of superficial atoms via sputtering, which may lead to the retraction of the studied phases. Since these phases have different different compositions and crystalline structures, of which the diffusivity and solubility of nitrogen in them are dependent, a different response for each type of phase can be expected. In this article, an innovative methodology has been developed to quantify and clarify which effects are predominant in the course of nitriding for each of these phases. The results indicate that phase expansion prevails over sputtering.
Comparison of different organic solvents used in the luminescent material for OLED devices
Authors: Santos Emerson Roberto , Ono Eric Tsuneki Yoshiura , Onmori Roberto Koji , Hui Wang Shu
Published: September 2024

In this work, organic light-emitting diode (OLED) devices were mounted using the structure: glass (as substrate)/indium tin oxide (ITO) (as anode)/poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) (as hole transport layer)/poly[9,9-dioctifluorene-alt-bis-tienilene(benzotiadiazole)] (PFTB) (as luminescent material)/aluminum-doped zinc oxide (AZO) (as electron transport layer)/aluminum (as cathode). The PFTB was synthetized at laboratory and diluted in different organic solvents as chloroform and trichlorobenzene. The I-V curves of OLED devices showed that the trichlorobenzene used to dillute the PFTB improved the performance for OLED devices promoting the highest electrical current of ≈50 mA and the lowest range of thresold voltage from ≈2.5 to 5 volts, while the device OLEDs mounted with PFTB dilutted in chloroform presented maximum electrical current of ≈23 mA and range of thresold voltage from ≈5 to 8 volts. A hypothesis that explain these results can be attributed to the boiling point of the organic solvent of trichlorobenzene (≈214.4ºC) to be higher than the one of the chloroform (≈61.1ºC), favoring better rearrangement of the polymer chains of PFTB and interfaces between thin films PFTB/PEDOT:PSS and PFTB/AZO improving the injection of charges (holes and electrons) inside the OLEDs devices.
Different electrode anodes used in OLED devices
Authors: Santos Emerson Roberto , Fullenbach Thiago de Carvalho , Medeiros Marina Sparvoli , Zambom Luis da Silva , Onmori Roberto Koji , Hui Wang Shu
Published: September 2024

Transparent conductive oxides (TCOs) known as indium tin oxide (ITO) and fluorine tin oxide (FTO) deposited on glass were compared by different techniques and also as anodes in organic light-emitting diode (OLED) devices with same structure. ITO produced at laboratory was compared with the commercial one manufactured by different companies: Diamond Coatings, Displaytech and Sigma-Aldrich, and FTO produced at laboratory was compared with the commercial one manufactured by Flexitec Company. FTO thin films produced at laboratory presented the lowest performance measured by Hall effect technique and also by I-V curve of OLED device with low electrical current and high threshold voltage. ITO thin films produced at laboratory presented elevated sheet resistance in comparison with commercial ITOs (approximately one order of magnitude greater), that can be related by a high number of defects as discontinuity of the chemical lattice or low crystalline structure. In the assembly of OLED devices with ITO and FTO produced at laboratory, neither presented luminances. ITO manufactured by Sigma-Aldrich company presented better electrical and optical characteristics, as low electrical resistivity, good wettability, favorable transmittance, perfect physicalchemical stability and lowest threshold voltage (from 3 to 4.5 V) for OLED devices.
Assertiveness as a social and psychological factor of adaptation of migrant women
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, TSYKALENKO Olga , VLASOVA Olena ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: September 2024

B a c k g r o u n d . Assertiveness is considered to be a significant characteristic of a woman, which determines her ability to effectively interact with the surrounding society on an equal footing and maintain mental health. The article presents a study of assertiveness as a factor in the socio- psychological adaptation of Ukrainian migrant women. The study is based on the hypothesis that there is a positive relationship between the development of assertiveness and the success of social and psychological adaptation of migrant women. It is assumed that the presence of assertiveness in such women is also associated with their higher subjective well-being. M e t h o d s . To obtain empirical data, the following methods were used: "Research of Assertiveness Level" (V. Capponi and T. Novak), Method of Social-Psychological Adaptation by C. Rogers and R. Diamond, "PERMA-Profiler" Questionnaire (Butler and Kern). The SPSS Statistics version 26.0 statistical package and the standard MS Excel program package were used to analyze the obtained data. Descriptive statistics are used to calculate group mean, minimum and maximum values, and standard deviation of mass data. Also applied: Kolmogorov – Smirnov and Shapiro – Wilk criteria, Kruskal-Wallis criterion for independent samples, and Pearson's correlation coefficient. Sample. 52 Ukrainian women aged 19 to 72 years who, because of the Russian-Ukrainian war, became migrants or ended up in safer regions of Ukraine as internally displaced persons. R e s u l t s . During the study, direct connections of assertiveness as a factor in the organization of the interaction of migrant women with representatives of an unfamiliar environment with the effectiveness of their social and psychological adaptation processes and the level of subjective well-being were statistically confirmed. C o n c l u s i o n s . Assertiveness is a statistically significant factor that helps Ukrainian women, who ended up abroad because of the war, to overcome life challenges associated with a forced change in the social and cultural environment.
Significance of correcting magnesium deficiency in different groups of women in surgical menopause
Authors: Blinov D. V. , Gromova О. A. , Solopova A. G. , Ezhova A. A. , Kuznetsova A. S. , Kalashnikova I. S. , Bitsadze V. О. , Makatsariya A. D.
Published: September 2024

Background. In the 21st century, there is a clear trend towards an increase in the proportion of women with climacteric syndrome (CS) and surgical menopause. Medical care for such patients usually includes menopausal hormone therapy (MHT), which often causes changes in magnesium and pyridoxine metabolism and their deficiency, leading to the development of adverse reactions. Therefore, it is necessary to improve rehabilitation programs designed to increаse the quality of life (QoL) for this category of gynecological patients.

Objective: to assess the profile of women with CS and surgical menopause receiving and not receiving MHT and to identify the significance of magnesium deficiency (MD) effect on the recovery process.

Material and methods. The observational non-interventional study included a total of 9168 women, of which 1528 patiеnts with CS and surgical menopause were taking MHT (Group 1), and 1528 patients with CS and surgical menopause were not taking MHT (Group 2). The Magnesium Deficiency Questionnaire (MDQ) was used to determine the number of participants with MD. A biochemical blood test was also performed, including determination of plasma magnesium concentration. The patients’ profile was analyzed for general somatic pathologies, obstetric and gynecological history, complaints, and MD symptoms using visual analogue scale. To assess QoL before the start of 4-week MD replenishing course and at the end of therapy, the World Health Organization Quality of Life Questionnaire (WHOQL-26) was applied.

Results. The MDQ data showed that the prevalence of DM in Group 1 was higher compared to Group 2. In both groups, women with hypomagnesemia had a higher incidence of viral infections, vegetative-vascular dystonia, osteochondrosis and arterial hypertension, more pronounced sleep disorders, irritability, back pain, rapid fatigue, and higher MDQ scores. After completion of the course of therapy with magnesium citrate and pyridoxine combination, the MDQ scores in patients with DM decreased along with an increase in plasma magnesium concentration. Besides, women's satisfaction with their physical, psychological, social wellbeing and microsocial support increased, and self-perception improved. A decrease in the severity of DM and a significant improvement in QoL according to WHOQOL-26 were demonstrated in patients with CS and surgical menopause after therapy.

Conclusion. The profile of patients with CS and surgical menopause, regardless of MHT, is often characterized by DM and decreased QoL. It seems reasonable to include blood magnesium level monitoring and DM correction in the comprehensive rehabilitation program for such patients.
Blood-brain barrier breach after acute cerebral hypoxia in infants
Authors: Aleksandrov A. G. , Blinov D. V.
Published: September 2024

Background. Neuronal lesion, including hypoxic-ischemic damage to the central nervous system (CNS) in perinatal period, leads to the release of neuron-specific enolase (NSE) into peripheral bloodstream. Consequently, NSE can be considered as a biological marker of nervous system injury. Based on NSE level analysis, timely rehabilitation for newborns can be provided, thereby reducing the likelihood of complications associated with CNS injury.

Objective: retrospective assessment of NSE level in peripheral blood over a 24-week period in infants of different gestational age with perinatal hypoxic-ischemic CNS damage.

Material and methods. The study included 49 newborns who had suffered perinatal hypoxic-ischemic CNS lesion. Gestation period differed from 32 to 41 weeks. The control group consisted of 28 healthy full-term infants. NSE levels were measured using enzyme immunoassay. Patients of the main group were additionally divided into subgroups depending on Apgar scores at the 1st minute after birth, gestational age, as well as predominant CNS lesion – hemorrhagic with intraventricular hemorrhages or ischemic with periventricular leukomalacia.

Results. Throughout the observation period, NSE concentrations were inversely correlated with Apgar scores: lower Apgar indicators were associated with higher NSE levels. In addition, the subgroup of 32–33-week gestational age had significantly higher NSE concentrations compared with 34–36-week, 37–41-week subgroups, and control group. NSE levels in infants with periventricular leukomalacia were consistently lower than those in newbornes with intraventricular hemorrhage starting from the 1st week. Notably, a delayed increase in serum NSE concentrations was observed at the 4th week.

Conclusion. The obtained data indicate that blood-brain barrier permeability for NSE is preserved during perinatal hypoxicischemic CNS injury. Serum NSE concentration measurement can serve as a valuable tool in clinical practice for assessing the effectiveness of therapy at the stages of treatment and rehabilitation.
Rehabilitation of patients after surgical treatment for polycystic ovary syndrome
Authors: Zaitseva O. A. , Solopova A. G.
Published: September 2024

One of the most common gynecologic diseases is polycystic ovary syndrome (PCOS). The pathologic conditions caused by this syndrome require careful attention from not only gynecologists, but also therapists, endocrinologists, oncologists, cardiologists, and psychologists. The reproductive function of women with PCOS and associated infertility needs further careful study. At the same time, it is necessary to develop measures for the correction and prevention of all disorders associated with this pathology. The article describes the importance of multidisciplinary, comprehensive approach to PCOS patients, the need to study and implement rehabilitation means aimed at restoring all aspects of women's health, including after surgical treatment.
Восприятие мифа о пещере Платона студентами очного и дистанционного форматов обучения
Authors: Лапшин Василий Андреевич
Published: September 2024

В статье представлены результаты исследования восприятия студентами мифа о пещере Платона. Проверяется гипотеза о том, что студенты вместо попыток самостоятельно анализировать источник даже небольшого объема скорее предпочтут опереться на уже готовое решение, представленное в учебнике или на интернет-ресурсе.

Приводятся материалы исследования, проведенного с участием студентов очной и дистанционной (очно-заочной, заочной) форм обучения. Также рассматривается источниковая база заимствований, сделанных студентами вместо самостоятельного выполнения задания. Анализируется способность критического восприятия студентами источников и способность к традуктивным (по аналогии) умозаключениям.
Формирование новой японской скульптуры
Authors: Кужель Юрий Леонидович
Published: September 2024

Предметом статьи является становление новой японской скульптуры конца XIX — первой трети XX в., а также переход мастерами ваяния от монументальности и пафоса конных статуй, скульптурных портретов героизированных исторических лиц к изображению реальной красоты тела человека, выразительности его позы. Подарив фигурам движение, скульпторы оживили их и внесли в свои работы богатую палитру живых эмоций и переживаний. Искусство японских скульпторов западного направления отразило эпоху с ее тенденцией к реалистическому обобщению. Автор стремится выявить, описать и понять, какими средствами достигается художественная выразительность скульптуры периода модернизации страны и формирования современного искусства, которому западная пластика придала свежий импульс. Методологически статья базируется на принципах комплексного подхода, использовании эмпирического материала, с помощью которого анализируются конкретные произведения. В процессе исследования применялись исторический, типологически-системный, аналитический методы.

Основным результатом данного исследования является возможность раскрытия специфических черт японской светской скульптуры. В качестве резюме в статье отмечается, что новое поколение мастеров объектами изображения выбрало не канонические персонажи из буддийского пантеона божеств — будд, бодхисаттв, светлых царей, небесных государей и др.,  а общественно значимые, знаковые фигуры из реальной японской истории и обычных людей из числа ученых, актеров и, что особенно ценно, женщин. В поле интересов скульпторов попали и представители животного мира. Кроме того, прослеживаются черты трансформации изображений героев в системе культурологических вызовов того времени, исторических фактов и эстетических законов, что вместе с расширением знаний о новой скульптуре Японии и через осознание ее роли и смыслов в контексте времени определяет новизну исследования.
Current possibilities and prospects of tocolytic therapy
Authors: Kiryanova Anastasia O. , Murashko Andrey V.
Published: September 2024

The urgency of the problem of preterm birth (PB) is because of its high prevalence and neonatal mortality. The effects of PB on the fetus are often fatal, and PB accounts for 70% of neonatal mortality and 36% of infant mortality. Severe neurological deficits (e.g., cerebral palsy, epilepsy, intraventricular hemorrhages, retinopathy, blindness, hearing loss, delayed neuropsychiatric and motor development) occur in 68% of surviving premature infants. Additionally, children born prematurely have a high risk for purulent septic diseases. The metabolic consequences of prematurity cause diseases such as metabolic syndrome and hypertension. Thus, tocolytic therapy is a crucial therapeutic measure in obstetrics. However, most known and actively used tocolytic drugs induce insufficient effect for long-term prolongation of pregnancy or have serious side effects. Currently, there is a search for new tocolytics to obtain safe, adequate, and long-term effects. This review examines promising and relevant drugs that may be used in routine obstetric practice. Scientific articles, meta-analyses, and systematic reviews from the databases PubMed, Embase, Web of Science, and Google Scholar, and RSCI were analyzed. For the analysis, publications in English and posted no more than 5 years before the study was conducted were selected, except for fundamental works with a longer publication period.
Complications of deep infiltrative endometriosis of gastrointestinal tract
Authors: Popov Alexander A. , Puchkov Konstantin V. , Troshina Vlada V. , Sopova Julia I. , Fedorov Anton A. , Tyurina Svetlana S. , Ovsiannikova Maiia R. , Ershova Irina Y. , Mamedova Solmaz G.
Published: September 2024

Objective. To summarize the literature data on the main complications of deep infiltrative endometriosis, including ileocecal.
Endometriosis is a complex disease that can begin to develop from birth. Despite all the already existing theories of the origin and development of this disease, further large-scale studies are required to investigate the etiology, pathogenesis, and phenotypes of this nosology and its relationship with pain and infertility.
External genital endometriosis often affects various parts of the gastrointestinal tract. The rectosigmoid junction of the colon is most commonly affected (81.3%), followed by the appendix (6.4%), small intestine (4.7%), dome of the cecum (4.1%), and other parts of the gastrointestinal tract (1.7%).
In recent years, interest in ileocecal endometriosis and its timely diagnosis and treatment has begun to grow among practicing specialists. Presently, deep infiltrative endometriosis is widely studied by obstetricians–gynecologists and by related specialists, such as general surgeons, coloproctologists, and gastroenterologists, in connection with extragenital lesions leading to severe complications. Cases of intestinal perforation caused by deep infiltrative endometriosis, bleeding, and small intestinal obstruction have been described.
Diagnostic accuracy of artificial intelligence for the screening of prostate cancer in biparametric magnetic resonance imaging: a systematic review
Authors: Kryuchkova Oksana V. , Schepkina Elena V. , Rubtsova Natalia A. , Alekseev Boris Y. , Kuznetsov Anton I. , Epifanova Svetlana V. , Zarya Elena V. , Talyshinskii Ali E.
Published: September 2024

BACKGROUND: Based on the latest published data, 40,137 new cases of prostate cancer were reported in Russia in 2021, ranking second after lung cancer in men.
Thus, prostate cancer is one of the most common malignant neoplasms in men. Accurate and timely detection of prostate cancer is important under the current conditions.
AIM: This systematic review aimed to assess the quality of prediction models designed to detect prostate cancer during initial presentation.
MATERIALS AND METHODS: A systematic search was performed in eLibrary.ru, PubMed, Google Scholar, Web of Science, and ResearchGate for relevant publications indexed from January 2019 to September 2023 in accordance with the PRISMA protocol. Two authors independently assessed the relevant studies for potential inclusion or exclusion.
RESULTS: This systematic review meta-analysis included 21 studies. In total, data from 3,630 patients were analyzed, of which 47% had prostate cancer and 53% had benign prostate neoplasms. The mean age of the patients was 67.1 (36–90) years. In addition, 81% of the studies were based on T2-weighted imaging, 57% on diffusion-weighted imaging, and 76% on apparent diffusion coefficient. Moreover, 43% and 33% of the studies were dedicated to transition zone and prostate peripheral zone neoplasms, respectively, and 52% of the authors examined the whole prostate gland, without dividing it into zones. The most common machine-learning algorithms applied by the investigators were as follows: multiple logistic regression (76%), support vector machine (38%), and random forest (24%). Based on the meta-analysis performed for the receiver operating characteristic-area under the curve (ROC–AUC) assessment with random-effect approach in 73 prediction models described in the publications, the final ROC–AUC was 0.793 [95% CI 0.768–0.818], I2 = 86.71%, p 0.001. The most accurate prediction models were based on the T2-weighted imaging + apparent diffusion coefficients imaging protocol: 0.860 [95% CI 0.813–0.907], and models created according to the “white box” principle (0.834 [95% CI 0.806–0.861]) were more accurate than the “black box” ones (0.733 [95% CI 0.695–0.771]). The models using radiomics and clinical features were slightly more accurate than those using the radiomics parameters alone (0.869 [95% CI 0.844–0.895] vs. 0.779 [95% CI 0.751–0.807]). Model accuracy was nearly identical across transitional and/or peripheral zone studies.
CONCLUSIONS: Artificial intelligence demonstrated promising results. However, the clinical applicability may require more intensive expert inspection in healthcare institutions and evaluation of efficacy in prospective studies.
Tinea capitis, caused by Microsporum canis (felineum) : literature review and clinical cases
Authors: Yakovlev Alexey B. , Polonskaia Aleksandra S. , Kruglova Larisa S.
Published: September 2024

According to statistics, tinea capitis remains the main mycological problem in childhood. The spectrum of causative agents of tinea capitis varies depending on the continent. In epidemiological terms, the pathogenic fungus Microsporum canis (felineum)absolutely predominates on the Eurasian continent.
A significant problem in the diagnosis and, in particular, in the treatment of microsporia are cases of the disease in very young children: we estimate this most problematic age from 1 to 18 months. Microsporia in children under the age of 1 year is the most relevant in pediatric clinical mycology due to the limited arsenal of topical and systemic medications approved at this age.
The clinical case presented in this article demonstrates an example of successful treatment of scalp microsporia in a 7-month-old child who had contraindications to systemic therapy. It should be noted that the duration of treatment in this case was almost 4 months, while the most effective therapy regimens, including systemic drugs, lead to the elimination of pathogenic fungus from the foci on the scalp within 30–45 days.
Photogallery. HIV infection and neoplastic skin diseases
Authors: Prozherin Sergey V.
Published: September 2024

Malignant neoplasms constitute a group of the most important secondary diseases that develop in people infected with the human immunodeficiency virus (HIV). The first neoplastic disease described in HIV-infected patients is Kaposi's sarcoma. In contrast to other types of Kaposi's sarcoma, its epidemic (AIDS-associated) type is more common in young and middle-aged HIV-positive individuals, especially among men who have same-sex sex. Epidemic Kaposi's sarcoma does not have a favourite localisation. However, there is a tendency to lesions of the scalp (face, ear flaps), upper extremities, anogenital area, oral mucosa. On the trunk, the pathological process spreads along the Langer lines. Skin rashes are represented by spotty, papular, nodular elements of red-brown or purple colour. The aggressive course is characteristic: rapid dissemination and generalisation of rashes.
Plasmoblastic lymphoma is associated with immunodeficiency states and is rare. The tumour lesion is usually located in the oral cavity. Few cases of plasmoblastic lymphoma with skin and soft tissue involvement have been described in the literature.
Squamous cell skin cancer in the context of HIV infection is a dangerous disease. In people living with HIV, it manifests at a significantly earlier age and is associated with a high risk of local recurrence. The extent of invasion and the likelihood of metastasis are influenced by HIV-associated immunodeficiency.
In the vast majority of cases, risk factors and clinical manifestations of basal cell skin cancer do not differ from those in immunocompetent individuals. Basal cell carcinomas rarely metastasise. Nevertheless, metastatic forms lead to unfavourable outcome.
Here is a photo gallery of cases of neoplastic skin lesions developed in HIV-positive patients.
The miR-338-3p expression level in pemphigus diagnosis
Authors: Teplyuk Natalia P. , Mak Daria V. , Kolesova Yuliya V. , Lepekhova Anfisa A. , Fedotcheva Tatiana A. , Ulchenko Darya N.
Published: September 2024

BACKGROUND: Pemphigus is a group of potentially fatal chronic cutaneous diseases in which blisters appear on the skin and mucous membranes as a result of IgG autoantibodies binding to desmosomes in the epidermis, leading to keratinocytes acantholysis. Currently, methods to monitor disease activity and therapy efficiency using various biomarkers are being investigated. MicroRNA expression, in particular miR-338-3p, has been one of these biomarkers, as changes in miR-338-3p expression may trigger the Th1/Th2 cell imbalance and possibly be involved in the pathogenesis of the disease.
AIM: This study aimed to design a protocol to evaluate the level of miR-338-3p expression in peripheral blood mononuclear cells and verify the diagnostic value of miR-338-3p expression in pemphigus.
MATERIALS AND METHODS: Experimental prospective comparative study was conducted from February 2023 to February 2024 at the Dermatology Department of Sechenov University. The study included 10 patients with pemphigus in the active stage of the disease, 3 patients in remission, and 9 participants of the control group. The expression of miRNA-338-3p was analyzed by real-time polymerase chain reaction, cDNA was obtained using StemLoop method. The evaluation of miRNA-338-3p expression level was based on its comparison with the expression of U6 gene using 2-ΔΔСt method.
RESULTS: The expression level of miR-338-3p was analyzed in 10 patients in the active stage of the disease (5 men, 50%; 5 women, 50%; mean age 46±10.7 years), 3 patients in remission (2 women, 66.7%; 1 man, 33.3%; mean age 57±8 years), 9 control group (8 women, 88.9%; 1 man, 11.1%; mean age 36±16.8 years). The mean expression level of miR-338-3p was 8.64 (SD±5.72) in patients with active disease, 3.38 (SD±1.44) in patients in remission, and 1.48 (SD±1.12) in controls. A statistically significant increase in the expression level of miR-338-3p was found in patients in the active disease stage compared to the control group (p=0.002). A statistically significant correlation was found between the level of miR-338-3p expression and the PDAI index score (p 0.001).
CONCLUSION: Based on the data obtained in this study, it can be assumed that microRNAs are important in pemphigus, and miR-338-3p expression in particular may serve as a key element in pemphigus pathogenesis. More detailed study of microRNAs and analysis of expression variability according to clinical data may provide the basis for developing new diagnostic methods and severity scoring, allowing more accurate and less invasive diagnostic methods, as well as monitoring and predicting disease progression.
Experimental investigation of enhanced CO2 refrigeration systems at varying operating condi-tions
Authors: Doerffel Christian , Barta Riley , Thomas Christiane , Hesse Ullrich
Published: September 2024

The efficiency of a CO2 refrigeration system depends mainly on the operating conditions and the system
design. To increase the energy efficiency, advanced system designs include additional components and their combinations such as parallel compression, ejectors, and expansion machines. For a direct comparison of different system designs, measurements were performed on an advanced CO2 laboratory refrigeration system at different operating conditions. The system behaviour was investigated at different gas cooler outlet temperatures, varying cooling loads, different evaporation temperatures and amounts of superheating. The results of the measurements performed on a baseline system configuration and advanced system designs are presented. It was observed that the influence of operating conditions is less important for certain measures in terms of efficiency improvement than for others. For each system design, operating conditions were identified under which a particularly advantageous behaviour of the respective measures was found. In the future, this will allow the judgment of the efficiency enhancement of each of different respective features for each individual application.
Assessment of the competence approach of dentists of various specialties in providing medical care to patients with increased tooth abrasion
Authors: Kazantsev Mikhail V. , Isaeva Natalia V.
Published: September 2024

BACKGROUND: This study examines the main aspects of the competence-based approach of dentists in the treatment of patients with increased tooth abrasion (ITA). ITA is a serious problem that can lead to oral diseases and tooth loss. The competence-based approach in the treatment of patients with ITA plays a key role in the prevention and treatment of this disease. A study examining the knowledge of dentists in providing care to patients with ITA will reveal the level of training of specialists in this field. This will allow us to assess the need for additional training and advanced training of dentists for the effective treatment of patients with ITA. The results of the study can be used to improve the work of dental institutions and educational programs for dentists. This will improve the quality of dental care, improve the prognosis of the disease in patients with ITA and reduce the risk of complications.
AIM: To evaluate the knowledge of dentists of different specialties in providing care to patients with ITA.
METHODS: The research is based on the results of a sociological survey conducted by questioning 175 dentists of different specialties. The survey was conducted according to the questionnaire developed by us «Assessment of professional competence in the tactics of managing patients with ITA by dentists of different profiles». The questionnaire included general information about the respondent (age, specialty), questions related to ITA (concept, complaints, symptoms, prevention, treatment), assessment of the questionnaire procedure.
RESULTS: The study demonstrated a relatively low competence approach of dentists of various specialties in the prevention and treatment of patients with ITA.
CONCLUSION: The study shows the lack of interaction between dentists in the treatment of ITA. The results of the study and the high prevalence of ITA have determined the need to develop clinical recommendations for the prevention and treatment of ITA.
Intricacies and Issues of Biotechnological Invention in the Light of Civil, Tax and Accounting Law
Authors: Anioł Emilia , Biała Emilia , Brauze Katarzyna
Published: September 2024

The main research problem of the article is the juridical assessment of a biotechnological invention in the light of civil, tax and accounting law. The aim is to present the issue of biotechnological invention from the perspective of various areas of law, the process of shaping current legislation in this field, as well as a review of Polish and EU case law. The work presents a broader analysis of biotechnological inventions in three branches of law: civil, tax and accounting. In the context of civil law, the principles of legal protection of this type of inventions were analyzed, as well as their impact on civil law relations. The main aspects of the regulation of biotechnological inventions in Polish civil law are presented, including the criteria for granting patents, as well as issues related to intellectual property. The importance of a balance between the protection of innovation and social interests and the need to constantly adapt the law to dynamically developing biomedical technologies were emphasized. Legal analysis based on tax law showed how complex the subject of the biotechnological invention is. All theses were supported by literature, legislation and case law. Tax law shows the potential of the invention and the possibilities associated with it. The accounting law segment of the study determines the categorization of biotechnological inventions within the appropriate framework of the legal system by identifying the relevant legal provisions.
Legal Status of Monument Buildings in the Context of Enterprise Asset Management
Authors: Błaszczak Julia , Cichosz Hubert , Dudewicz Filip
Published: September 2024

The purpose of the article is to present regulations relating to monument buildings in various areas of law in the Polish legal system. One of the key aspects is to examine the way of regulating the status of monument buildings in tax law. The article is divided into three parts in which the authors discuss the following issues: civil law regulations, the status of monument buildings in accounting law and taxation of monument buildings. Within the Polish legal system, heritage buildings are typically subject to different regulations than other real estate, as shown in this study.
MEZAR STELLERİ IŞIĞINDA ANTİK DÖNEMDE AXYLON BÖLGESİ’NİN SOSYAL VE EKONOMİK YAPISI
Authors: Kurt Mehmet
Published: September 2024

Antik Dönemde Tatta Limnē’nin (Tuz Gölü) batısından Laodikeia’nın (Konya-Ladik) kuzeyine kadarolan Kuzey Lykaonia bozkırlarına Axylon denilmekteydi. Arazi yapısının yer yer değişiklik göstermesinden kaynaklı olarak Doğu, Güneydoğu ve Batı olmak üzere farklı bölümler halinde değerlendirilen bölge, günümüzdeki Konya ili Kadınhanı, Sarayönü, Cihanbeyli ve kısmen Kulu ilçelerini kapsamaktadır. Axylon, ağaçsız ülke anlamına gelmekte olup, Axylon’un Doğu kesimi,Proseilemmene olarak da adlandırılmıştır. Bugün olduğu gibi Antik Dönemde de bölgenin temel geçim kaynağını tarım ve hayvancılık oluşturmuştur. Antik edebi kaynaklar bölgenin sosyal ve ekonomik durumuna dair sınırlı bilgi vermektedir. Bununla birlikte Antik Dönemde Axylon olarak adlandırılmış bölgedeki yerleşim yerlerinden elde edilen mezar stelleri üzerinde yer alan tasvirler, bölge insanlarının çiftçilikle uğraştıklarını bütün açıklığıyla gözler önüne sermektedir. Öyle ki özellikle mezar stelleri üzerindeki bezeme unsurlarının büyük ekseriyeti zirai faaliyetlerle ilgili unsurlardır. Çift sürme sahneleri, saban, boyunduruk, buğday başağı, asma yaprağı, üzüm salkımı, yün sepeti, iğ, öreke bütün bölgede çok sık görülen figürlerdir. İşte bu çalışmada yazılı kaynaklar ve özellikle mezar stellerinin üzerlerindeki tasvirler yoluyla bölgenin Antik Dönem sosyal ve ekonomik hayatı ele alınmıştır.
HÜSEYİN NİHAL ATSIZ’IN ESERLERİNDE ESKİ TÜRK İNANÇLARI VE KÜLTÜRLE İLGİLİ GÖRÜŞLERİ
Authors: Toprak Abdulhamit
Published: September 2024

Hüseyin Nihal Atsız, yazdığı eserleriyle yirminci yüzyıl Türk edebiyatı, tarihi ve kültürünün önemli fikir adamlarından ve yazarlarındadır. Atsız’ın bu yönü teorik ve kurgusal türdeki eserlerini eski Türk inanç ve kültürü bakımından incelemede yol gösterici faktör olmuştur. Nitel araştırma yönteminin uygulandığı çalışmada, veri toplama aracı yazarın eserleri olup elde edilen veriler de ise içerik analizi yapılmıştır. Bu yönden bakıldığında özellikle Deli Kurt, Ruh Adam ve Bozkurt romanlarında görülen eski Türk inançları ve kültürüyle ilgili önemli verilerin içerik analizi yapılmıştır. Yapılan bu analizle eski Türk inanç ve kültürünün geçmişten günümüze kadar olan yansımaları değerlendirilmiştir. Türklerin genel itibariyle İslamiyet’i kabul etmelerine kadar göçebe bir hayat sürdürmeleri, yerleşik hayata sonra geçmeleri (Uygurlar) ve sosyo-ekonomik sebeplerle farklı kültür, medeniyet ve dinlerle etkileşimde bulundukları fikri oluşmuştur. Bu çalışmada; yaşam tarzlarının, savaş ve göç gibi faktörlerin ve kültürel ilişkilerin dinî inanç ve kültür üzerindeki etkilerini göstermenin yanı sıra Türklerin tarihî süreç içinde yaşadıkları din ve inanışların edebî eserlere yansıması ve Atsız’ın kültürle ilgili görüşleri dile getirilmek istenmiştir.
INTEGRATING MULTIMODAL ADAPTATION INTO TRANSLATOR TRAINING: A THEORETICAL RATIONALE
Authors: Sağlam Naciye
Published: September 2024

With evolving multimedia communication, traditional translation studies focusing on fidelity are being transformed by the need for multimodal and intersemiotic approaches. Extending this discussion to translator training, this study argues for the necessity of teaching adaptation skills in the training of future translators in line with the needs of the multimedia age.
By viewing translation as a process of re-creation, the study stresses the often-overlooked creative potential of translation. At this point, the inclusion of adaptations in translator training offers the opportunity to experience the inherent creative potential of translation and emphasizes the intersemiotic dimension. The paper first offers a theoretical justification for this approach, then discusses methods of implementation as well as potential benefits. Integrating adaptation into translator training can be approached theoretically, analytically, and practically. It offers advantages such as broadening the scope of translation beyond language, bridging the gap between training and market needs, and enhancing interdisciplinary knowledge.
Assessing the Economic Value of The Hydropower Energy: The Role of Social Capital and Socio-economic Factors
Authors: Ferico Firdauzi Jovanka , Saptutyningsih Endah , Boedirochminarni Arfida
Published: September 2024

A good strategy for dealing with environmental problems and improving environmental sustainability. This study examines the extent to which local communities in Yogyakarta, Kulon Progo area, Indonesia are willing to increase hydropower energy. The influence of social capital on people's willingness to get involved was studied using a logistic regression model. Based on the findings, 95% of residents are likely to make financial contributions to improve hydropower energy facilities. Increased social capital, consisting of strong interpersonal relationships, community involvement, and trust, is strongly associated with this engagement. This study adds to the literature by emphasizing the possible function of social capital in the process of adjustment to changes in renewable energy from hydropower energy in households.
The Effect of Economic Growth on The Human Development Index in Indonesia
Authors: Asmara Galuh Jati , Asmara Gea Dwi , Saleh Rahmat
Published: September 2024

This study aims to test and analyze the effect of economic growth on the Human Development Index in 34 provinces in Indonesia. This research uses quantitative data methods. The independent variable used in this study is economic growth with control variables, namely poverty and population. The dependent variable used is the Human Development Index. The data type used is panel data, a combination of time series and cross-section. Time series data was obtained from 2015-2020, and cross-section data was obtained from 34 provinces in Indonesia. The data used is secondary data sourced from the Central Statistics Agency (BPS) report, especially from 2015 to 2020. Hypothesis testing in this study uses multiple linear regression with the Chow test, Hausman test, t-test, f-test, and coefficient of determination test. The results show that economic growth had no significant effect on the Human Development Index in Indonesia in 2015-2020, Ceteris Paribus. The control variables of poverty and population influence the Human Development Index. The poverty control variable has a significant negative effect, and the population control variable has a significant positive impact. This study contributes new empirical evidence to fill gaps and address inconsistencies in the existing literature on the relationship between economic growth and human development.