bluuebunny/crossref_metadata_2025 huggingface dataset:
METODE SIMILARITY UNTUK ALTERNATIF REKOMENDASI BUKU PADA SISTEM INFORMASI PERPUSTAKAAN
Authors: Faisal Muhammad , Astuti Indah Puji , Buntoro Ghulam Asrofi
Published: August 2023

Pendataan anggota dan buku di perpustakaan SMA Kyai Ageng Basyariyah saat ini masih menggunakan sistem manual yang mana pendataan anggota dan koleksi buku masih ditulis dalam buku catatan khusus. Banyaknya buku yang ada diperpustakaan menjadi kendala bagi siswa dalam melakukan pencarian buku. Terlebih lagi ketika seorang siswa mencari suatu buku yang mana belum tentu tersedia apakah masih ada buku tersebut ataukah habis terpinjam, kemudian tidak adanya pengetahuan alternatif buku rekomendasi apabila buku tersebut kosong, sehingga managemen peminjaman buku tidak terorganisir dengan baik. Maka dari itu diperlukan sebuah sistem untuk menyelesaikan permasalahan tersebut. Penggunaan sistem Informasi perpustakaan berbasis web sangatlah membantu meningkatkan kinerja perpustakaan agar lebih efektif. Dengan menambahkan fitur alternatif rekokmendasi buku menggunakan methode similarity pada sistem tersebut dapat mempermudah siswa dan petugas dalam mencari pilihan alternatif apabila buku yang dicari kosong atau tidak ada. Pada penelitian ini sistem dibangun menggunakan SDLC model prototype. Pengujian sistem menggunakan beberapa pengujian seperti pengujian kecepatan, fungsionalitas, dan ketepatan dalam menampilkan alternatif buku. Dengan adanya sistem pengelola perpustakaan ini, dapat memudahkan manajemen mulai dari pendataan buku, peminjaman, pencarian buku dan rekomendasi buku sesuai dengan judul yang diinputkan.
Sistem Pendeteksi Jenis Penyakit Pernafasan Menggunakan Metode Gabungan GRU dan LSTM Melalui Suara Pasien dengan Gangguan Pernafasan
Authors: Jatmiko Andriyan , Hendrawan Nofrian Deny , Affandi Arif Saivul , Susanto Divira Salsabiil
Published: August 2023

Gated Recurrent Unit (GRU) dan Long Short-Term Memory (LSTM) adalah dua jenis Recurrent Neural Network (RNN) yang dirancang untuk mengatasi masalah vanishing gradient pada RNN tradisional. Secara umum, baik GRU maupun LSTM dapat digunakan dalam pemrosesan Natural Language Processing (NLP) seperti pengenalan ucapan hingga deteksi suara, terjemahan mesin, dan generasi teks. Penelitian ini bertujuan untuk mengklasifikasikan penyakit pernapasan berdasarkan suara pasien menggunakan gabungan GRU dan LSTM. Model GRU dilatih dengan 50 epoch menggunakan dataset suara pasien yang dikumpulkan. Hasil evaluasi menunjukkan akurasi training sebesar 75% dan training validation 73%, dengan precision, recall, dan f1-score yang bervariasi untuk setiap jenis penyakit pernapasan dengan relevansi terhadap f1-score dan nilai support. Penelitian ini menggambarkan potensi penggunaan metode klasifikasi suara dalam diagnosis penyakit pernapasan. Meskipun demikian, perlu dilakukan penyesuaian parameter dan peningkatan jumlah data pelatihan untuk meningkatkan performa model. Dengan konvergensi yang baik pada epoch 50, hasil ini menunjukkan kemampuan model dalam mengklasifikasikan penyakit pernapasan berdasarkan suara pasien. Namun, validasi dan pengujian lebih lanjut pada dataset yang lebih besar diperlukan untuk menguji keandalan dan generalisasi model secara menyeluruh. Penelitian ini dapat memberikan kontribusi dalam pengembangan alat bantu diagnostik non-invasif untuk penyakit pernapasan berdasarkan analisis suara pasien. Penelitian ini memberikan bukti awal tentang potensi metode klasifikasi suara dalam diagnosis penyakit pernapasan. Namun, penyesuaian parameter dan peningkatan jumlah data pelatihan perlu dilakukan untuk meningkatkan performa model secara keseluruhan.
Diagnosis of mixed infection and a primary immunodeficiency disease using next-generation sequencing: a case report
Authors: Zhang Xiaolei , Wang Yixue , Pen Daly , Liu Jing , Zhou Qinhua , Wang Yao , Zhong Huaqing , Liu Tingyan , Chen Weiming , Wu Bingbing , Zhou Yang , Wang Chuanqing , Li Xiangyu , Yu Fangyou , Wang Xiaochuan , Lu Guoping , Yan Gangfeng
Published: August 2023

Major Histocompatibility Complex Class II (MHC II) deficiency is a rare primary immunodeficiency disorder (PID) with autosomal recessive inheritance pattern. The outcome is almost fatal owing to delayed diagnosis and lacking of effective therapy. Therefore, prompt diagnosis, timely and effective treatment are critical. Here, we report a 117-day-old boy with diarrhea, cough, cyanosis and tachypnea who was failed to be cured by empiric antimicrobial therapy initially and progressed to severe pneumonia and respiratory failure. The patient was admitted to the pediatric intensive care unit (PICU) immediately and underwent a series of tests. Blood examination revealed elevated levels of inflammatory markers and cytomegalovirus DNA. Imaging findings showed signs of severe infection of lungs. Finally, the diagnosis was obtained mainly through next-generation sequencing (NGS). We found out what pathogenic microorganism he was infected via repeated conventional detection methods and metagenomic next-generation sequencing (mNGS) of sputum and bronchoalveolar lavage fluid (BALF). And his whole exome sequencing (WES) examination suggested that CIITA gene was heterozygous mutation, a kind of MHC II deficiency diseases. After aggressive respiratory support and repeated adjustment of antimicrobial regimens, the patient was weaned from ventilator on the 56th day of admission and transferred to the immunology ward on the 60th day. The patient was successful discharged after hospitalizing for 91 days, taking antimicrobials orally to prevent infections post-discharge and waiting for stem cell transplantation. This case highlights the potential importance of NGS in providing better diagnostic testing for unexplained infection and illness. Furthermore, pathogens would be identified more accurately if conventional detection techniques were combined with mNGS.
CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia
Authors: Sun He , Gao Wei , Chen Rongzhang , Chen Si , Gu Xia , Wang Feilong , Li Qiang
Published: August 2023

Background

The transcriptomic studies targeting circular RNAs (circRNAs) in bronchoalveolar lavage fluid (BALF) exosomes of acute respiratory distress syndrome (ARDS) patients caused by severe pneumonia have rarely been reported. This study aimed to screen and validate abnormally expressed circRNAs in exosomes from BALF of patients with ARDS caused by severe pneumonia and then evaluate the diagnostic values of these circRNAs for ARDS.

Method

BALF was collected from four patients with ARDS caused by severe pneumonia and four healthy subjects. CircRNA expression profile was obtained by microarray analysis in BALF exosomes of the discovery cohort. The differentially expressed circRNAs in BALF exosomes were verified by real-time quantitative PCR (RT-qPCR) and underwent competitive endogenous RNA (ceRNA) network construction and functional enrichment analysis.

Results

A total of 629 circRNAs were differentially expressed in BALF exosomes between ARDS patients and healthy subjects. Nine differentially expressed circRNAs were validated by RT-qPCR, and seven were consistent with the results of microarray analysis. CeRNA network analysis was performed for hsa_circRNA_002809, hsa_circRNA_042882, and hsa_circRNA_104034. Functional enrichment analysis showed that the target genes were mainly associated with hypoxia-induced damage, inflammatory response, and the HIF-1 signaling pathway. Hsa_circRNA_042882 and hsa_circRNA_104034 can be regarded as promising diagnostic biomarkers for patients with ARDS caused by severe pneumonia, with remarkable sensitivity and specificity of the area under the curve of 0.8050 and 1 or 0.835 and 0.799, respectively.

Conclusion

This study obtained circRNA expression profiles of ARDS patients, and hsa_circRNA_042882 and hsa_circRNA_104034 were regarded as promising diagnostic biomarkers for patients with ARDS caused by severe pneumonia.
Sacubitril/valsartan versus valsartan in regressing myocardial fibrosis in hypertension: a prospective, randomized, open-label, blinded endpoint clinical trial protocol
Authors: Lee Vivian , Zheng Qishi , Toh Desiree-Faye , Pua Chee Jian , Bryant Jennifer A. , Lee Chi-Hang , Cook Stuart A. , Butler Javed , Díez Javier , Richards A. Mark , Le Thu-Thao , Chin Calvin W. L.
Published: August 2023

Background

Diffuse interstitial myocardial fibrosis is a key common pathological manifestation in hypertensive heart disease (HHD) progressing to heart failure (HF). Angiotensin receptor–neprilysin inhibitors (ARNi), now a front-line treatment for HF, confer benefits independent of blood pressure, signifying a multifactorial mode of action beyond hemodynamic regulation. We aim to test the hypothesis that compared with angiotensin II receptor blockade (ARB) alone, ARNi is more effective in regressing diffuse interstitial myocardial fibrosis in HHD.

Methods

Role of ARNi in Ventricular Remodeling in Hypertensive LVH (REVERSE-LVH) is a prospective, randomized, open-label, blinded endpoint (PROBE) clinical trial. Adults with hypertension and left ventricular hypertrophy (LVH) according to Asian sex- and age-specific thresholds on cardiovascular magnetic resonance (CMR) imaging are randomized to treatment with either sacubitril/valsartan (an ARNi) or valsartan (an ARB) in 1:1 ratio for a duration of 52 weeks, at the end of which a repeat CMR is performed to assess differential changes from baseline between the two groups. The primary endpoint is the change in CMR-derived diffuse interstitial fibrosis volume. Secondary endpoints include changes in CMR-derived left ventricular mass, volumes, and functional parameters. Serum samples are collected and stored to assess the effects of ARNi, compared with ARB, on circulating biomarkers of cardiac remodeling. The endpoints will be analyzed with reference to the corresponding baseline parameters to evaluate the therapeutic effect of sacubitril/valsartan vs. valsartan.

Discussion

REVERSE-LVH will examine the anti-fibrotic potential of sacubitril/valsartan and will offer mechanistic insights into the clinical benefits of sacubitril/valsartan in hypertension in relation to cardiac remodeling. Advancing the knowledge of the pathophysiology of HHD will consolidate effective risk stratification and personalized treatment through a multimodal manner integrating complementary CMR and biomarkers into the conventional care approach.

Clinical Trial Registration: ClinicalTrials.gov, identifier, NCT03553810.
A data-driven method for total organic carbon prediction based on random forests
Authors: Gui Jinyong , Gao Jianhu , Li Shengjun , Li Hailiang , Liu Bingyang , Guo Xin
Published: August 2023

The total organic carbon (TOC) is an important parameter for shale gas reservoir exploration. Currently, predicting TOC using seismic elastic properties is challenging and of great uncertainty. The inverse relationship, which acts as a bridge between TOC and elastic properties, is required to be established correctly. Machine learning especially for Random Forests (RF) provides a new potential. The RF-based supervised method is limited in the prediction of TOC because it requires large amounts of feature variables and is very onerous and experience-dependent to derive effective feature variables from real seismic data. To address this issue, we propose to use the extended elastic impedance to automatically generate 222 extended elastic properties as the feature variables for RF predictor training. In addition, the synthetic minority oversampling technique is used to overcome the problem of RF training with imbalanced samples. With the help of variable importance measures, the feature variables that are important for TOC prediction can be preferentially selected and the redundancy of the input data can be reduced. The RF predictor is finally trained well for TOC prediction. The method is applied to a real dataset acquired over a shale gas study area located in southwest China. Examples illustrate the role of extended variables on improving TOC prediction and increasing the generalization of RF in prediction of other petrophysical properties.
Research on dual lateral log simulation of shale bedding fractures under different influencing conditions
Authors: Wang Naihui , Li Kesai , Sun Jiaqi , Wang Di , He Xianhong , Xiang Zehou , Liu Hui , Wang Pan
Published: August 2023

Micro scale fractures play a crucial role in facilitating the migration of oil and gas in low permeability shale reservoirs. However, the identification of such fractures is a complex task. The efficacy of the dual lateral log physical field changes as a means of identifying shale micro fractures remains uncertain. To address this issue, a three-layer shale bedding fracture model was developed using the finite element method and core and conventional logging data from eight wells, which was based on different shale reservoirs within the Yanchang Formation in the Ordos Basin. The present study examines the dual lateral log response characteristics resulting from distinct characteristics of horizontal bedding fractures, with a focus on the response mechanism. The simulation of logging response characteristics of shale and siltstone combination were utilized by core statistical data for verification purposes. The results indicate that under the lithology combination of shale and siltstone, the magnitude of the difference between the resistivity of the filled fracture and the formation resistivity, the greater the formation resistivity of the shale itself, the wider the fracture width, and the greater the difference between the apparent resistivity and the real formation resistivity. Furthermore, the suitable conditions for the detection of shale bedding fracture characteristics by dual lateral log are clarified. In the presence of effective filling, the dual lateral log has the capability to identify shale fractures at the micron scale. The findings of our study establish a theoretical framework for the identification and assessment of shale fractures, and furnish technical assistance for the optimal selection of “sweet spots” within shale reservoirs and the precise evaluation of reservoirs. This study lays a theoretical foundation for the identification and evaluation of shale fractures, and provides technical support for the optimal “sweet spot” selection of shale reservoirs and the accurate evaluation of reservoirs.
Antimicrobial effects of XF drugs against Candida albicans and its biofilms
Authors: Board-Davies E. L. , Rhys-Williams W. , Hynes D. , Love W. G. , Williams D. W.
Published: August 2023

Compared with antibiotics for treating bacterial infections, there are a limited number of antifungal agents. This is due to several factors, including the difficulties of identifying suitable antifungals that target the fungal cell without damaging host cells, and the reduced rates of diagnosis of fungal infections compared with those caused by bacteria. The problem of treating fungal infections is exacerbated by an increasing incidence of antifungal resistance among human fungal pathogens. Three XF drugs (XF-73, XF-70, and DPD-207) have previously displayed innate bactericidal effects and a low propensity for microbial resistance, with XF-73 and XF-70 having a second, light-activated mechanism of action [known as photodynamic therapy (PDT)]. In an effort to expand the repertoire of antifungal agents, this research assessed the in vitro activity of XF drugs via both mechanisms of action against six strains of the fungal pathogen Candida albicans in both planktonic and biofilm cultures. In addition, this research examined the effects of XF drug treatment on biofilms of C. albicans in a reconstituted human oral epithelium model. All C. albicans strains tested were susceptible to XF-73 and XF-70, with minimum inhibitory concentrations (MICs) between 0.25 µg/mL and 2 µg/mL; DPD-207 was less potent, with MICs between 4 µg/mL and 16 µg/mL, and light activation did not enhance these MICs. Complete biofilm eradication was not reported at the tested XF drug concentrations. However, live and dead staining of C. albicans cells in biofilms after XF drug treatment demonstrated that XF-73 and XF-70 were active against most Candida biofilms tested from 64 µg/mL; again, light activation did not enhance anti-biofilm activity. Candida biofilms were more resistant to DPD-207, with fungicidal effects occurring from 256 µg/mL. XF-73 and XF-70 reduced penetration of C. albicans biofilm into reconstituted human oral epithelium (RHOE) and resulted in less damage (as determined by reduced lactate dehydrogenase release) than untreated biofilms. Overall, the results highlight the potential of XF drugs as new drugs for the management of topical infections caused by C. albicans. Further studies are warranted on the development of XF drugs as antifungals, particularly for XF-73 and XF-70.
Advances in post-translational modifications of proteins and cancer immunotherapy
Authors: Li Yanqing , Zhang Runfang , Hei Hu
Published: August 2023

Protein post-translational modification (PTM) is a regulatory mechanism for protein activity modulation, localization, expression, and interactions with other cellular molecules. It involves the addition or removal of specific chemical groups on the amino acid residues of proteins. Its common forms include phosphorylation, ubiquitylation, methylation, and acetylation. Emerging research has highlighted lactylation, succinylation, and glycosylation. PTMs are involved in vital biological processes. The occurrence and development of diseases depends on protein abundance and is regulated by various PTMs. In addition, advancements in tumor immunotherapy have revealed that protein PTM is also involved in the proliferation, activation, and metabolic reprogramming of immune cells in tumor microenvironment. These PTMs play an important role in tumor immunotherapy. In this review, we comprehensively summarize the role of several types of PTMs in tumor immunotherapy. This review could provide new insights and future research directions for tumor immunotherapy.
Innovative delivery systems for epicutaneous immunotherapy
Authors: Wang Zhen , Wu Lingzhi , Wang Wei
Published: August 2023

Allergen-specific immunotherapy (AIT) describes the establishment of peripheral tolerance through repeated allergen exposure, which qualifies as the only curative treatment for allergic diseases. Although conventional subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) have been approved to treat respiratory allergies clinically, the progress made is far from satisfactory. Epicutaneous immunotherapy (EPIT) exploits the skin’s immune properties to modulate immunological response, which is emerging as a promising alternative and has shown effectiveness in many preclinical and clinical studies for both respiratory and food allergies. It is worth noting that the stratum corneum (SC) barrier impedes the effective delivery of allergens, while disrupting the SC layer excessively often triggers unexpected Th2 immune responses. This work aims to comprehend the immunological mechanisms of EPIT, and summarize the innovative system for sufficient delivery of allergens as well as tolerogenic adjuvants. Finally, the safety, acceptability, and cost-effectiveness of these innovative delivery systems are discussed, which directs the development of future immunotherapies with all desirable characteristics.
A holo-spectral EEG analysis provides an early detection of cognitive decline and predicts the progression to Alzheimer’s disease
Authors: Chu Kwo-Ta , Lei Weng-Chi , Wu Ming-Hsiu , Fuh Jong-Ling , Wang Shuu-Jiun , French Isobel T. , Chang Wen-Sheng , Chang Chi-Fu , Huang Norden E. , Liang Wei-Kuang , Juan Chi-Hung
Published: August 2023

Aims

Our aim was to differentiate patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) from cognitively normal (CN) individuals and predict the progression from MCI to AD within a 3-year longitudinal follow-up. A newly developed Holo-Hilbert Spectral Analysis (HHSA) was applied to resting state EEG (rsEEG), and features were extracted and subjected to machine learning algorithms.

Methods

A total of 205 participants were recruited from three hospitals, with CN (n = 51, MMSE > 26), MCI (n = 42, CDR = 0.5, MMSE ≥ 25), AD1 (n = 61, CDR = 1, MMSE < 25), AD2 (n = 35, CDR = 2, MMSE < 16), and AD3 (n = 16, CDR = 3, MMSE < 16). rsEEG was also acquired from all subjects. Seventy-two MCI patients (CDR = 0.5) were longitudinally followed up with two rsEEG recordings within 3 years and further subdivided into an MCI-stable group (MCI-S, n = 36) and an MCI-converted group (MCI-C, n = 36). The HHSA was then applied to the rsEEG data, and features were extracted and subjected to machine-learning algorithms.

Results

(a) At the group level analysis, the HHSA contrast of MCI and different stages of AD showed augmented amplitude modulation (AM) power of lower-frequency oscillations (LFO; delta and theta bands) with attenuated AM power of higher-frequency oscillations (HFO; beta and gamma bands) compared with cognitively normal elderly controls. The alpha frequency oscillation showed augmented AM power across MCI to AD1 with a reverse trend at AD2. (b) At the individual level of cross-sectional analysis, implementation of machine learning algorithms discriminated between groups with good sensitivity (Sen) and specificity (Spec) as follows: CN elderly vs. MCI: 0.82 (Sen)/0.80 (Spec), CN vs. AD1: 0.94 (Sen)/0.80 (Spec), CN vs. AD2: 0.93 (Sen)/0.90 (Spec), and CN vs. AD3: 0.75 (Sen)/1.00 (Spec). (c) In the longitudinal MCI follow-up, the initial contrasted HHSA between MCI-S and MCI-C groups showed significantly attenuated AM power of alpha and beta band oscillations. (d) At the individual level analysis of longitudinal MCI groups, deploying machine learning algorithms with the best seven features resulted in a sensitivity of 0.9 by the support vector machine (SVM) classifier, with a specificity of 0.8 yielded by the decision tree classifier.

Conclusion

Integrating HHSA into EEG signals and machine learning algorithms can differentiate between CN and MCI as well as also predict AD progression at the MCI stage.
Single-layer perceptron artificial visual system for orientation detection
Authors: Todo Hiroyoshi , Chen Tianqi , Ye Jiazhen , Li Bin , Todo Yuki , Tang Zheng
Published: August 2023

Orientation detection is an essential function of the visual system. In our previous works, we have proposed a new orientation detection mechanism based on local orientation-selective neurons. We assume that there are neurons solely responsible for orientation detection, with each neuron dedicated to detecting a specific local orientation. The global orientation is inferred from the local orientation information. Based on this mechanism, we propose an artificial visual system (AVS) by utilizing a single-layer of McCulloch-Pitts neurons to realize these local orientation-sensitive neurons and a layer of sum pooling to realize global orientation detection neurons. We demonstrate that such a single-layer perceptron artificial visual system (AVS) is capable of detecting global orientation by identifying the orientation with the largest number of activated orientation-selective neurons as the global orientation. To evaluate the effectiveness of this single-layer perceptron AVS, we perform computer simulations. The results show that the AVS works perfectly for global orientation detection, aligning with the majority of physiological experiments and models. Moreover, we compare the performance of the single-layer perceptron AVS with that of a traditional convolutional neural network (CNN) on orientation detection tasks. We find that the single-layer perceptron AVS outperforms CNN in various aspects, including identification accuracy, noise resistance, computational and learning cost, hardware implementation feasibility, and biological plausibility.
Liver Imaging Reporting and Data System (LI-RADS) v2018: differential diagnostic value of ADC values for benign and malignant nodules with moderate probability (LR-3)
Authors: Chen Xue , Cai Quanyu , Xia Jinju , Huang Huan , Li Zhaoxing , Song Kairong , Jia Ningyang , Liu Wanmin
Published: August 2023

Objective

To evaluate the usefulness of the apparent diffusion coefficient (ADC) in differentiating between benign and malignant LR-3 lesions classified by Liver Imaging Reporting and Data System 2018 (LI-RADS v2018).

Methods

Retrospectively analyzed 88 patients with liver nodules confirmed by pathology and classified as LR-3 by LI-RADS. All patients underwent preoperative contrast-enhanced MR examination, and the following patient-related imaging features were collected: tumor size,nonrim APHE, nonperipheral “washout”, enhancing “capsule”, mild-moderate T2 hyperintensity, fat in mass, restricted diffusion, and nodule-in-nodule architecture. We performed ROC analysis and calculated the sensitivity and specificity.

Results

A total of 122 lesions were found in 88 patients, with 68 benign and 54 malignant lesions. The mean ADC value for malignant and benign lesions were 1.01 ± 0.15 × 103 mm2/s and 1.41 ± 0.31 × 103 mm2/s, respectively. The ADC value of malignant lesions was significantly lower than that of benign lesions, p < 0.0001. Compared with other imaging features, ADC values had the highest AUC (AUC = 0.909), with a sensitivity of 92.6% and a specificity of 74.1% for the differentiation of benign and malignant lesions.

Conclusions

ADC values are useful for differentiating between benign and malignant liver nodules in LR-3 classification, it improves the sensitivity of LI-RADS in the diagnosis of HCC while maintaining high specificity, and we recommend including ADC values in the standard interpretation of LI-RADSv2018.
An unresectable and metastatic intrahepatic cholangiocarcinoma with EML4-ALK rearrangement achieving partial response after first-line treatment with ensartinib: a case report
Authors: Huang Senmiao , Li Dianhe , Huang Yongye , Lu Guojie , Tian Ying , Zhong Xuefeng , Zheng Yating , Huang Mengli , Huang Fuxi
Published: August 2023

Systemic chemotherapies are the primary treatment options for patients with unresectable and metastatic intrahepatic cholangiocarcinoma (ICC), but the effectiveness of current systemic therapies is limited. The development of targeted-therapy has changed the treatment landscape of ICC, and comprehensive genome sequencing of advanced cholangiocarcinoma patients could be beneficial to identify potential targets to guide individualized treatment. Herein, we reported an unresectable and metastatic ICC patient who detected EML4-ALK rearrangement in peripheral blood, which was later confirmed on tissue-based testing, and achieved partial response (PR) after first-line treatment with ensartinib. This case suggests that the liquid biopsy is of clinical value for unresectable or metastatic ICC, and the discovery of rare molecular targets provides new therapeutically approaches for advanced ICC patients.
Clinical evaluation of the three-dimensional printed strut-type prosthesis combined with autograft reconstruction for giant cell tumor of the distal femur
Authors: Tan Linyun , Li Ye , Hu Xin , Lu Minxun , Zhang Yuqi , Gan Yuxiong , Tu Chongqi , Min Li
Published: August 2023

Propose

This study aimed to describe the design and surgical techniques of a three-dimensional (3D) printed strut-type prosthesis with a porous titanium surface for distal femur giant cell tumors of bone (GCTB) and evaluate the short-term clinical outcomes.

Methods

From June 2018 to January 2021, 9 consecutive patients with grade I or II GCTB in the distal femur underwent extended intralesional curettage followed by 3D-printed strut-type prosthesis combined with autograft reconstruction were retrospectively reviewed to assess their clinical and radiographic outcomes.

Results

All patients were followed up for 30.8 ± 7.5 months (18–42 months) after surgery. The mean affected subchondral bone percentage and the mean subchondral bone thickness before surgery was 31.8% ± 9.6% (range, 18.2% ~50.2%) and 2.2 ± 0.8 mm (range, 1.2-4.0 mm), respectively. At the final follow-up, all the patients were alive without local recurrence; no postoperative complications were observed. Patients had significant improvements in postoperative MSTS-93 score [(26.7 ± 2.4) vs. (18.8 ± 3.7), P < 0.05], and ROM [(122.8° ± 9.1°) vs. (108.3° ± 6.1°), P < 0.05] compared with their preoperative statuses. Furthermore, the mean subchondral bone thickness has increased to 10.9 ± 1.3 mm (range, 9.1-12.1 mm).

Conclusion

3D-printed strut-type prosthesis combined with autograft reconstruction provides acceptable early functional and radiographic outcomes in patients with grade I or II GCTB in distal femur due to the advantages of the prosthesis such as good biocompatibility, osseointegration capacity, and subchondral bone protection. If our early outcomes can be further validated in studies with more patients and sufficient follow-up, this method may be evaluated as an alternative for the treatment of grade I or II GCTB in the distal femur.
Comparison of first-line treatment with CHOP versus ICED in patients with peripheral T-cell lymphoma eligible for upfront autologous stem cell transplantation
Authors: Kim Seok Jin , Jo Jae-Cheol , Yoon Dok Hyun , Yang Deok-Hwan , Yoon Sang Eun , Lee Gyeong-Won , Kong Jee Hyun , Park Yong , Kang Ka-Won , Lee Ho-Sup , Oh Sung Yong , Shin Ho-Jin , Lee Won Sik , Choi Yoon Seok , Jeong Seong Hyun , Kim Min Kyoung , Kang Hye Jin , Yi Jun Ho , Lim Sung-Nam , Yhim Ho-Young , Do Young Rok , Yun Hwan Jung , Eom Hyeon-Seok , Lee Mark Hong , Suh Cheolwon , Kim Won Seog
Published: August 2023

Introduction

Upfront autologous stem cell transplantation (ASCT) has been recommended for patients who are newly diagnosed with peripheral T-cell lymphoma (PTCL), and CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), an anthracycline-based chemotherapy has been the frontline chemotherapy for PTCL. However, it is not clear whether anthracycline-based chemotherapies such as CHOP could be standard induction therapy for PTCL.

Methods

We conducted a randomized phase II study to compare CHOP with fractionated ifosfamide, carboplatin, etoposide, and dexamethasone (ICED) for patients eligible for ASCT. The primary endpoint was progression-free survival (PFS) and secondary endpoints included objective response rate, overall survival (OS), and safety profiles.

Results

Patients were randomized into either CHOP (n = 69) or ICED (n = 66), and the characteristics of both arms were not different. PTCL-not otherwise specified (NOS, n = 60) and angioimmunoblastic T-cell lymphoma (AITL, n = 53) were dominant. The objective response rate was not different between CHOP (59.4%) and ICED (56.1%), and the 3-year PFS was not different between CHOP (36.7%) and ICED (33.1%). In AITL patients, CHOP was favored over ICED whereas ICED was associated with more cytopenia and reduced dose intensity. Patients who received upfront ASCT after achieving complete response to CHOP or ICED showed 80% of 3-year OS.

Discussion

In summary, our study showed no therapeutic difference between CHOP and ICED in terms of response and PFS. Thus, CHOP might remain the reference regimen especially for AITL based on its better outcome in AITL, and upfront ASCT could be recommended as a consolidation of complete response in patients with PTCL.
Changes in sleep quality of children with epilepsy and anxiety of their caregivers after COVID-19 infection: a case-series report
Authors: Li Dan , Shi Yongjing , Wang Bo , Zhou Jing , Wang Xueying , Huang Shaoping , Yang Lin
Published: August 2023

Objective

To study the changes in epileptic seizures and sleep quality in children with epilepsy (CWE) and the changes in anxiety of their caregivers after infection with COVID-19.

Methods

Outpatients and inpatients of CWEs were selected as subjects and a questionnaire survey was used to carry out this case-series study. The demographic information of the CWEs and their caregivers, information about epilepsy, and information about the vaccination, infection, and treatment of COVID-19 were collected. The changes in sleep quality of CWEs and the changes in anxiety of their caregivers were assessed by the Child Sleep Habits Questionnaire (CSHQ) and Caregiver Anxiety Scale (CAS). Risk factors affecting sleep habits in CWEs and caregiver anxiety were further analyzed by one-way analysis of variance.

Results

A total of 312 children were included in the study. Among them, 134 patients (42.9%) were female. The average age of the children was 9.30 ± 3.88 years, and the duration of epilepsy was 4.59 ± 3.36 years. A total of 221 of the 312 children were infected with COVID-19, and all the infected children developed fever, which lasted for 1.71 ± 1.13 days. 10 children were satisfied with controlled seizures for more than 1 year and relapsed after COVID-19 infection (4.2%), 4 cases (3.6%) with increased seizures, and 8 children with reduced seizures (7.7%), 17 children (7.7%) had no change in seizures, and 182 children (82.3%) remained seizure-free after the COVID-19 infection. The average sleep time of the CWEs was 9.25 ± 1.04 h and the average total score of the CSHQ was 37.25 ± 5.19, among which 44 cases (14.1%) had more than 41 points. As the result of the CAS, 16 of them (5.13%) scored above 50 and the average total score was 31.49 ± 8.09. The control of seizures, age of onset, types of anti-seizure medicines (ASMs), and seizure duration were risk factors affecting sleep quality. Accordingly, the score of CAS was significantly lower when there was more than one caregiver who cared for the CWE.

Conclusions

COVID-19 infection did not cause an increase in seizures in CWEs, nor did it worsen their sleep quality of them or aggravate the anxiety of their caregivers.
Kinematic analysis and process optimization of root-cutting systems in field harvesting of garlic based on computer simulation technology
Authors: Yu Zhaoyang , Yang Mingjin , Hu Zhichao , Gu Fengwei , Peng Baoliang , Zhang Yanhua , Yang Ke
Published: August 2023

Introduction

Root cutting is an important process in garlic field harvesting but is the weakest link in the full mechanization of garlic production. To improve the current situation of technological backwardness and poor operational quality of mechanized garlic root-cutting in the main garlic-producing regions of China, this study combined the physical characteristics and agronomic requirements of garlic plants, and proposed an innovative floating root-cutting technology for garlic combine harvesters that enables the top alignment of bulb, adaptive profiling floating of cutter, and embedded cutting of roots.

Methods

Through the kinematic analysis of the floating cutting process, the coordinate equations of the initial contact point of the bulb, the mathematical model of the floating displacement of the cutting component. Using computer simulation techniques, the dynamic simulation study of the floating cutting process was carried out in the rigid-flexible coupling numerical simulation model of root-cutting mechanism and garlic plant. The influence law of garlic conveying speed, extension spring preload force and stiffness on the floating displacement of the cutting component and the angular velocity of swing arm reset and its formation causes were analyzed by a single-factor simulation test. The key operating parameters of the root-cutting mechanism were optimized through the computerized virtual orthogonal test and fuzzy comprehensive evaluation.

Results and discussion

The significance of the factors affecting the floating cutting performance decreased in the following order: extension spring preload force, garlic conveying speed and extension spring stiffness. The optimal parameter combination of the root cutting mechanism obtained from the optimization were as follow: extension spring preload force was 16 N, garlic conveying speed was 0.8 m/s, and extension spring stiffness was 215 N/m. Tests conducted with the optimal parameter combination yielded a root excision rate of 92.72%, which meets the requirements of Chinese garlic field harvesting quality. This study provides computer simulation optimization methods for the optimal design of the root-cutting mechanism, and also provides technical and equipment support for the full mechanization of garlic production in China.
Potential biomarkers to predict return to fertility after discontinuation of female contraceptives—looking to the future
Authors: Cordova-Gomez Amanda , Wong Andrew P. , Sims Lee B. , Doncel Gustavo F. , Dorflinger Laneta J.
Published: August 2023

Nowadays there are multiple types of contraceptive methods, from reversible to permanent, for those choosing to delay pregnancy. Misconceptions about contraception and infertility are a key factor for discontinuation or the uptake of family planning methods. Regaining fertility (the ability to conceive) after contraceptive discontinuation is therefore pivotal. Technical studies to date have evaluated return to fertility by assessing pregnancy as an outcome, with variable results, or return to ovulation as a surrogate measure by assessing hormone levels (such as progesterone, LH, FSH) with or without transvaginal ultrasound. In general, relying on time to pregnancy as an indicator of return to fertility following contraceptive method discontinuation can be problematic due to variable factors independent of contraceptive effects on fertility, hormone clearance, and fertility recovery. Since the ability to conceive after contraceptive method discontinuation is a critical factor influencing product uptake, it is important to have robust biomarkers that easily and accurately predict the timing of fertility return following contraception and isolate that recovery from extrinsic and circumstantial factors. The main aim of this review is to summarize the current approaches, existing knowledge, and gaps in methods of evaluating return-to-fertility as well as to provide insights into the potential of new biomarkers to more accurately predict fertility restoration after contraceptive discontinuation. Biomarker candidates proposed in this document include those associated with folliculogenesis, cumulus cell expansion, follicular rupture and ovulation, and endometrial transport and receptivity which have been selected and scored on predefined criteria meant to evaluate their probable viability for advancement. The review also describes limitations, regulatory requirements, and a potential path to clinically testing these selected biomarkers. It is important to understand fertility restoration after contraceptive method discontinuation to provide users and health providers with accurate evidence-based information. Predictive biomarkers, if easy and low-cost, have the potential to enable robust evaluation of RTF, and provide potential users the information they desire when selecting a contraceptive method. This could lead to expanded uptake and continuation of modern contraception and inform the development of new contraceptive methods to widen user's family planning choices.
Motion Modelling of the Floating Bushing in an External Gear Pump Using Dimensional Analysis
Authors: Torrent Miquel , Gamez-Montero Pedro Javier , Codina Esteban
Published: August 2023

A new approach to model the motion of floating bushings in external gear pumps is presented in this article, where lubrication conditions have been introduced using dimensional analysis. This model is based on Bond Graph diagrams and has been experimentally validated in lab tests measuring the movement of the floating bushing inside the gear pump by means of laser micrometers. The novelty of this research is the creation of a simple and experimentally validated tool for the behaviour study of these types of pumps, which allows the simulation of a dynamic rigid solid in a fluid boundary with clearances of the order of microns, without using powerful CFD tools, with very short execution times, and using conventional computational tools. The qualitative behaviour of the model with respect to the experimental results is very similar, adjusting the numerical values with very acceptable accuracies by taking into account the precision of the experimental measurements, and allows us to use the model to interpret the volumetric and mechanical efficiency variations according the operating conditions.
The Neglected Plant Resources in Chinese Archaeobotany: Revealing Animals’ Feed during the Pre-Qin Period Using the Flotation Results in Northern China
Authors: Tang Liya , Yang Anqi , Han Kai
Published: August 2023

The functions of non-agricultural crops unearthed from archaeological sites mainly pertain to their usage as livestock feed. However, the studies of livestock feed have predominantly relied on qualitative analysis, which often lacks descriptive objectivity and relies heavily on subjective feelings and experiences. In this paper, we aim to address this gap by focusing on quantitative analysis, utilizing macro-plant remains from the data of seventy-five archaeological settlements and one archaeological investigation in northern China spanning the Neolithic Age to the Bronze Age, as well as stable isotope analyses of carbon and nitrogen. This research delves into various aspects, including the exploration of the plant resources and livestock farming and the categorization of feed types for cattle and pigs in captivity. By employing quantitative analysis, we can gain a more comprehensive and objective understanding of these subjects. This approach aligns with studies on ancient livestock management and feed diversity. In essence, the discussion of civilization development and social changes during the Pre-Qin period holds significant value when considering forage analysis, just as crop analysis has proven insightful. By focusing on the quantitative analysis of non-agricultural crops and their role as livestock feed, we can shed light on important aspects of ancient societies and their agricultural practices.
Salt and Water Stress Tolerance in Ipomoea purpurea and Ipomoea tricolor, Two Ornamentals with Invasive Potential
Authors: Mircea Diana-Maria , Li Riwen , Blasco Giménez Lorena , Vicente Oscar , Sestras Adriana F. , Sestras Radu E. , Boscaiu Mónica , Mir Ricardo
Published: August 2023

Invasive plants pose a significant threat to biodiversity, especially under the current unstable climatic conditions. This study aimed to test the salt and drought tolerance of two ornamental species of the genus Ipomoea during germination and vegetative growth. Germination tests were performed in the presence of increasing NaCl concentrations or iso-osmotic PEG concentrations—to mimic the osmotic stress caused by drought. Both species showed great invasive potential because of their high seed germination percentages and rapid germination under control (distilled water) and salt stress conditions, up to 200 mM NaCl. Germination and early seedling development were more affected in the presence of PEG. Subsequently, water stress (complete withholding of irrigation) and salt stress (watering with 100 mM and 200 mM NaCl) treatments were applied to young plants for three weeks, when all plants were harvested, to determine several morphological and biochemical parameters. Both species were sensitive to water deficit but relatively resistant to salt stress. Their salt stress responses were similar, based mainly on the inhibition of Na+ and the activation of K+ transport from roots to leaves and the uptake and accumulation of Ca2+; however, I. tricolor showed a slightly higher tolerance to salt stress than I. purpurea. Although I. tricolor has only been locally reported as invasive and is generally considered a ‘low-risk’ species, our results indicate that it may have an invasive potential even higher than I. purpurea, a recognised invasive weed, spread into areas with moderate salinity, affecting agricultural land or natural habitats of ecological interest.
Neuropsychiatric Lyme Disease and Vagus Nerve Stimulation
Authors: Biniaz-Harris Nicholas , Kuvaldina Mara , Fallon Brian A.
Published: August 2023

Lyme disease, the most common tick-borne disease in the United States, is caused by infection with the spirochete Borrelia burgdorferi. While most patients with acute Lyme disease recover completely if treated with antibiotics shortly after the onset of infection, approximately 10–30% experience post-treatment symptoms and 5–10% have residual symptoms with functional impairment (post-treatment Lyme disease syndrome or PTLDS). These patients typically experience pain, cognitive problems, and/or fatigue. This narrative review provides a broad overview of Lyme disease, focusing on neuropsychiatric manifestations and persistent symptoms. While the etiology of persistent symptoms remains incompletely understood, potential explanations include persistent infection, altered neural activation, and immune dysregulation. Widely recognized is that new treatment options are needed for people who have symptoms that persist despite prior antibiotic therapy. After a brief discussion of treatment approaches, the article focuses on vagus nerve stimulation (VNS), a neuromodulation approach that is FDA-approved for depression, epilepsy, and headache syndromes and has been reported to be helpful for other diseases characterized by inflammation and neural dysregulation. Transcutaneous VNS stimulates the external branch of the vagus nerve, is minimally invasive, and is well-tolerated in other conditions with few side effects. If well-controlled double-blinded studies demonstrate that transcutaneous auricular VNS helps patients with chronic syndromes such as persistent symptoms after Lyme disease, taVNS will be a welcome addition to the treatment options for these patients.
Primary Coenzyme Q10 Deficiency: An Update
Authors: Mantle David , Millichap Lauren , Castro-Marrero Jesus , Hargreaves Iain P.
Published: August 2023

Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and extra-mitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation, CoQ10 serves as a lipid soluble antioxidant and plays an important role in fatty acid beta-oxidation and pyrimidine and lysosomal metabolism, as well as directly mediating the expression of a number of genes, including those involved in inflammation. Due to the multiplicity of roles in cell function, it is not surprising that a deficiency in CoQ10 has been implicated in the pathogenesis of a wide range of disorders. CoQ10 deficiency is broadly divided into primary and secondary types. Primary CoQ10 deficiency results from mutations in genes involved in the CoQ10 biosynthetic pathway. In man, at least 10 genes are required for the biosynthesis of functional CoQ10, a mutation in any one of which can result in a deficit in CoQ10 status. Patients may respond well to oral CoQ10 supplementation, although the condition must be recognised sufficiently early, before irreversible tissue damage has occurred. In this article, we have reviewed clinical studies (up to March 2023) relating to the identification of these deficiencies, and the therapeutic outcomes of CoQ10 supplementation; we have attempted to resolve the disparities between previous review articles regarding the usefulness or otherwise of CoQ10 supplementation in these disorders. In addition, we have highlighted several of the potential problems relating to CoQ10 supplementation in primary CoQ10 deficiency, as well as identifying unresolved issues relating to these disorders that require further research.