bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation, chromatographic evaluation and biodistribution of 99mTc-procainamide as a radiopharmaceutical for heart imaging
Authors: Motaleb M. A. , Ibrahim I. T. , Abo Rizq R. S. , Elzanfaly E. S.
Published: October 2016

Procainamide (4-amino-N-[2-(diethylamino) ethyl] benzamide) is a sodium channel blocker, which acts as an effective antiarrhythmic agent used in the treatment of a variety of atrial and ventricular arrhythmias. The aim of this study was to prepare 99mTc-procainamide complex, apply different chromatographic techniques for the assay of radiolabeling yield and study its biodistribution as a novel radiopharmaceutical for heart imaging. 99mTc-procainamide was obtained with a maximum labeling yield of 95.76±0.20% via direct labeling method under optimum conditions of 200 μg of procainamide, 300 μL of buffer (carbonate) at pH 11, 30 μg SnCl2·2H2O at room temperature (25°C) for 15 min. In terms of in vitro stability, the complex was stable for 3 h. Chromatographic evaluation using paper chromatography, thin layer chromatography, gel chromatography, and high performance liquid chromatography showed reliable results for measuring the radiochemical yield. Biodistribution study of 99mTc-procainamide showed ratios of heart/lung and heart/liver (6.38±1.50, 2.06±0.31, respectively at 30 min post injection) which was comparable to that of 99mTc-sestamibi (7.4±2.00, 0.97±0.10, respectively at 60 min, P<0.05).
Progress on nanoparticle-based carbon nanotube complex: fabrication and potential application
Authors: Termeh Yousefi Amin , Fukumori Minoru , Reetu Raj Pandey , Liu Polin , Fu Lingxiang , Bagheri Samira , Tanaka Hirofumi
Published: October 2016

Carbon nanotubes (CNTs) are considered as one of the most intensively explored nanostructured materials and have been widely used as a platform material for metal and semiconductor nanoparticles (NPs) due to their large and chemically active surface area. Several approaches have been described in the literature to immobilize NPs on the surface of CNTs. This report reviews the recent developments in this area by exploring the various techniques where nanotubes can be functionalized with NPs to improve the optical, mechanical, thermal, medical, electrical, and magnetic applications of CNTs.
Investigation of penetration into woven fabric specimens impregnated with shear thickening fluid
Authors: Kordani Naser , Sadough Vanini Ali
Published: October 2016

In this paper, the effect of weight fraction of nano silica (hydrophilic fumed silica particles) and molecular mass of polyethylene glycol (PEG) on the rheological properties such as the critical shear rate of fluids has been studied. Dynamic moduli based on strain and the effects of increasing the molecular weight are presented. Constructed samples with high-molecular-weight PEG have higher initial, final and critical viscosities. Also, higher molecular chains in the polymer and preventing the movement of most of these chains against the relative motion of liquid (viscosity) will cause higher viscosity in samples. Critical shear rate is lower in the provided samples with high-molecular-weight PEG. Polymer branches in these suspensions are absorbed by the surface of the particles. Due to OH bonds in the silica particles and also due to the presence of this bond in PEG, creating a hydrogen bond is likely. Such a hydrogen bond between the polymer yarn and the particle surface causes surface absorption of the particles. To show the effect of molecular weight on fibers, woven fabric specimens impregnated with shear thickening fluid (STF) have been examined by penetration and pressure test diagrams have been investigated. In a sample with higher molecular weight, displacement to yield point is higher and residence to penetration does not show much difference.
Effect of coir fiber reinforcement on mechanical properties of vulcanized natural rubber composites
Authors: Patil Yogesh , Sharma Sumit
Published: October 2016

In this study, the effect of coir fiber reinforcement on the mechanical properties of vulcanized natural rubber composite has been studied. An attempt has been made to predict the effect on tensile strength, maximum load, and elongation at break (%) of coir fiber-reinforced vulcanized natural rubber composites under cold, heat, and water aging tests. The natural rubber was vulcanized at 150°C. The fibers were soaked in a 5% solution of NaOH for 48 h at room temperature. At different temperatures, cold, heat, and water aging resistance tests were conducted to understand the behavior of the composite under different environment. The properties recorded after aging tests were compared with initial properties to investigate the effect of fiber reinforcement. The results revealed that the samples containing coir fiber showed better performance after each aging test. The specimens showed the highest properties in case of water aging resistance.
Structure elucidation and synthesis of hydroxylated isatins from Streptomycetes
Authors: Shaaban Khaled A. , Shaaban Mohamed , Nair Vimal , Schuhmann Imelda , Win Hnin Yu , Lei Lei , Dittrich Birger , Helmke Elisabeth , Schüffler Anja , Laatsch Hartmut
Published: October 2016

Chemical investigation of terrestrial and marine streptomycete isolates led to the identification of two new natural pigments, namely, 6-hydroxyisatin (3) and 6-hydroxy-5-methoxyisatin (4). Additionally, the strains delivered numerous known compounds, among them N

β
-acetyltryptamine, N-acetyltyramine, phenylacetamide, N-(2-phenethyl)acetamide, 1-acetyl-β-carboline, tyrosol, 2′-deoxyadenosine, 2′-deoxythymidine, anthranilic acid, 2′-deoxyuridine, indolyl-3-acetic acid, indolyl-3-carboxylic acid, and p-hydroxybenzoic acid. The isatin structures were deduced by NMR and mass studies and further confirmed by synthesis and by X-ray diffraction of the isomeric 5-hydroxy-6-methoxyisatin (5).
Indides RE
3
T
2In4 (RE = Y, Gd–Tm, Lu; T = Ni, Ru, Rh) with a ZrNiAl superstructure
Authors: Heying Birgit , Niehaus Oliver , Rodewald Ute Ch. , Pöttgen Rainer
Published: October 2016

Three series of rare earth-transition metal-indides RE
3
T
2In4 (RE=Y, Gd–Tm, Lu; T=Ni, Ru, Rh) were synthesized from arc-melted RE
3
T
2 precursor compounds and indium tear shot in sealed niobium ampoules using different annealing sequences. The new indides crystallize with the hexagonal Lu3Co2In4-type structure, space group P6̅. All samples were characterized on the basis of Guinier powder patterns and six structures were refined from single crystal X-ray diffractometer data. The RE
3
T
2In4 structures are derived from the ZrNiAl type through RE/In ordering, paralleled by a symmetry reduction from P6̅2m to P6̅. This induces twinning for some of the investigated crystals. The main crystal chemical motifs of the RE
3
T
2In4 structures are trigonal prisms of rare earth, respectively indium atoms that are filled by the transition metals.
Der Quasi-Markt für Arbeitsvermittlung in Deutschland: Welche Rolle spielen Vertrags- und Trägermerkmale bei ausgeschriebenen Vermittlungsdienstleistungen?
Authors: Bernhard Sarah
Published: October 2016

In Germany, the public employment service partially contracts out job placement services to private providers. Do the private provider’s characteristics or the contract design or remuneration influence the job searcher’s probability to be placed into a new job? To answer these questions we analyze unique administrative data of the Federal Employment Agency with cox proportional hazard regressions. Job searchers have a higher propensity to be placed into a new job by a private provider when the provider is a non-profit organization or when the private provider had above-average placement rates in the past. Result-oriented remuneration of providers, such as “no-cure, no pay” and “nocure, less pay” models and contract elements that allow enhancing quality, positively influence the propensity to obtain a job.
Ether and Wireless
Authors: Navarro Jaume
Published: October 2016

With the creation of the BBC in 1922, wireless sets ceased to be obscure devices for military and commercial communication, and became household goods to entertain the British middle classes. Wireless amateurs, electrical engineers, inventors, and specialized physicists engaged in a cultural exchange among themselves and with the general public to explain and understand the mechanisms and possibilities of the new technology. This created a new arena for discussions on the existence of the ether at a time when highly esoteric physics (mainly relativity, but also quantum physics) had triggered a debate about its very existence. In this paper I explore the ways in which the ether saw its popularity renewed by its link to the modern wireless technologies. I argue that far from being part of an old, outdated physics, radio broadcasting was instrumental for the ether to remain popular, and even an element of modernity, among many wireless amateurs, engineers, and the general public in the 1920s and early 1930s.
RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity
Authors: Gu Meidi , Liu Zhiyong , Lai Rongrong , Liu Si , Lin Wenlong , Ouyang Chuan , Ye Sheng , Huang He , Wang Xiaojian
Published: October 2016

TANK‐binding kinase 1 (TBK1) activation is a central event in type I interferon production in anti‐virus innate immunity. However, the regulatory mechanism underlying TBK1 activation remains unclear. Here we report that Raf kinase inhibitory protein (RKIP) is essential for TBK1 activation and type I interferon production triggered by viral infection. Upon viral infection, RKIP is phosphorylated at serine 109 (S109) by TBK1. Phosphorylation of RKIP enhances its interaction with TBK1 and in turn promotes TBK1 autophosphorylation. Mutation of RKIP S109 to alanine abrogates the interaction between RKIP and TBK1, and the anti‐viral function of RKIP. RKIP deficiency inhibits intracellular double‐stranded RNA‐ or DNA‐induced type I interferon production. Consistently, RKIP deficiency renders the mice more susceptible to vesicular stomatitis virus (VSV) and herpes simplex virus (HSV) infections. This study reveals a previously unrecognized positive feedback loop between RKIP and TBK1 that is essential for type I interferon production in anti‐viral innate immunity.
Clinical presentation, treatment and outcome of anaplastic thyroid carcinoma: results of a multicenter study in Germany
Authors: Wendler Julia , Kroiss Matthias , Gast Katja , Kreissl Michael C , Allelein Stephanie , Lichtenauer Urs , Blaser Rainer , Spitzweg Christine , Fassnacht Martin , Schott Matthias , Führer Dagmar , Tiedje Vera
Published: October 2016

Context

Anaplastic thyroid carcinoma (ATC) is an orphan disease and confers a dismal prognosis. Standard treatment is not established.

Objective

The aim of this study is to describe clinical characteristics, current treatment regimens and outcome of ATC and to identify clinical prognostic markers and treatment factors associated with improved prognosis.

Design

Retrospective cohort study at five German tertiary care centers.

Patients and methods

Totally 100 ATC patients diagnosed between 2000 and 2015 were included in the analysis. Disease-specific overall survival (OS) was compared with the Kaplan–Meier method and log-rank test; Cox proportional hazard model was used to identify risk factors.

Results

The 6-month, 1-year and 5-year disease-specific OS rates were 37, 28 and 5%, respectively. Stage-dependent OS at 6 months was 78, 54 and 18% for stage IVA, B and C, respectively. 29% patients survived >1 year. Multivariate analysis of OS identified age ≥70 years, incomplete local resection status and the presence of distant metastasis as significant risk factors associated with shorter survival. Radical surgery (hazard ratio [HR] 2.20, 95% confidence interval (CI) 1.19–4.09, P = 0.012), external beam radiation therapy (EBRT) ≥40 Gy (HR = 0.34, 0.15–0.76, P = 0.008) and any kind of chemotherapy (CTX) (HR = 11.64, 2.42–60.39, P = 0.003) were associated with longer survival in multivariate analyses adjusted for age and tumor stage. A multimodal treatment regimen was significantly associated with a survival benefit (HR = 1.04, 1.01–1.08, P < 0.0001) only in IVC patients.

Conclusion

Disease-specific OS is still poor in ATC. Treatment factors associated with improved OS provide a rationale to devise treatment pathways for routine care. Collaborative research structures should be aimed to advance treatment of ATC.
Web service to support decision-making for beef cattle production systems in Cárdenas- Tabasco, Mexico
Authors: Sánchez-Díaz Baltazar , Vargas-Villamil Luis Manuel , Zavala-Cruz Joel , Del Rivero Bautista Nydia , Gonzalez-Camacho Juan Manuel , Crespo-Pichardo Guillermo , Menéndez-Domínguez Victor Hugo
Published: October 2016

The researchers propose a methodology to share, process, and exchange agricultural information among different applications through a Web service. The Web service will be available online and mobile and can be used as a tool for decision-making. Initially, agricultural regions and cartography of the study area were identified. Subsequently, a simulation model of potential yield of pasture and animal behavior by regions and area, was designed. Finally, a Web service, using Amazon Web Services and REST for exchanging information, was developed. Web services in the cloud, enable interoperability using data, mapping information of agricultural regions, simulation models, and protocols for data transfer, thus making available the prediction results.
Evaluation of sustainability and the impact of the agriculture styles of the chilean coastal dry lands
Authors: González Ulibarry Paco , García Elizalde Pedro , Gastó Corderch Juan , De Kartzow Garcia Alejandro , Obando Ulloa Javier Mauricio
Published: October 2016

Agriculture has been progressing continuously, from the use of free natural resources to the fossil fuels as energy sources. Even though agriculture depends mainly on ecosystem resources and services, its development has been apparently centered only on yield, not considering neither the ecological value of the negative externalities nor the decapitalization of the resources that influence sustainability. Thus, the information on the evaluation of the sustainability on different agriculture styles is scarce or almost null. This investigation evaluates the sustainability in different agriculture styles (intensive horticulture, traditional farm and self-sustaining horticulture) established in Hualqui (Region of Biobío, Chile), through the energy flows present on each style to measure the impact generated on the land. The results revealed that the self-sustaining horticulture style showed a higher sustainability compared to the traditional farm and intensive horticulture style. These results can contribute to the public, policies to reorient the action strategy to encourage the sustainability in the different agriculture styles.
Predicción científica y prescripción en mejora genética vegetal en cuanto Ciencia Aplicada de Diseño: El caso de la mejora de frutales del género Prunus
Authors: Martínez-Gómez Pedro
Published: October 2016

La mejora genética vegetal tiene una doble índole científica: Ciencia Empírica de la Naturaleza y Ciencia Aplicada de Diseño. En este contexto el presente trabajo pretende indagar en la predicción científica como rasgo esencial de esta disciplina en cuanto Ciencia Aplicada de Diseño con especial referencia la mejora de frutales de hueso (del género Prunus). En mejora genética vegetal podemos hablar de tres niveles de conocimiento asociados a la biología molecular (nivel micro), la constitución genética de un individuo (nivel meso) y al fenotipo o aspecto global de la nueva variedad (nivel macro), que afectan tanto a los tipos de predicción como a las metodologías a aplicar. La predicción constituye el objetivo principal de la mejora genética como Ciencia de Diseño. Es clave tener un conocimiento del futuro posible para poder hacer un nuevo diseño que estará completo al cabo de algunos años, más de 12 años en el caso de los frutales de hueso que es el objeto de este trabajo. Asimismo, es necesario tener en cuenta en el desarrollo de esta predicción científica aplicada a la mejora de Prunus diversas variables internas (la naturaleza genética del material vegetal de partida, las metodologías disponibles, etc.) y externas (la aceptación social, los factores medioambientales, los estreses bióticos y abióticos, etc.) a la hora de llevar a cabo esta predicción. El grado de conocimiento de estas variables determinará la calidad de la predicción en el diseño de nuevas variedades de Prunus.
Degradation of Red Ferralitic (Rhodic Ferralsol) tobacco soils in the Artemisa province, Cuba
Authors: Ricote Jorge Óscar
Published: October 2016

“Partido” is a tobacco growing area that extends for some 3.000 hectares between the municipalities of San Antonio de los Baños, Güira de Melena and Alquízar in the Cuban province of Artemisa. Predominant soils are Red Ferralitic (Rhodic Ferralsol according to the World Reference Base), with a strong tendency to alkalinization which has a negative impact on the quality of their agricultural use. The objective of this work was to quantify the geographical extension of the degradation process, to determine how deep it happens along the soil profile and to establish its possible relationship with the quality and quantity of water applied to tobacco fields. The chemical, physical and mineralogical analyses of two test pits carried out in the area were compared: one profile without agricultural use with one characteristic soil profile under continuous production. After being subjected to the same irrigation regime in laboratory conditions, it was concluded that degradation affects to 89.56% of the area of tobacco soils evaluated; this phenomenon occurs very deeply along the soil profile and happens downwards, causing the accumulation of calcium and the loss of sodium and potassium in the superficial horizon, what is shown in pH rises. Such processes, associated to irrigation water and to insufficient rainfall regime that are traditional in the territory, have led to changes in the mineralogical composition of these tobacco soils ~ appearance of minerals such as gibbsite which was absent in uncultivated Red Ferralitic soils ~ which involve the modification of soil classification at gender level.
Overview of the Rural Agrarian Landscapes and Evolution of Their Types in Lithuania
Authors: Valčiukienė Jolanta , Atkocevičienė Virginija , Juknelienė Daiva
Published: October 2016

The forms and types of residential areas are conditioned by historical and socio-economic conditions of the country. Development of industrial relations have evolved and accommodation system in rural areas. Tenure and land-use changes played the most important role in the development of rural land. Modern rural residential areas formed under the influence of certain particularities characteristic to one or the other region of the country. The article analyzes five major periods of landscape development, land reform factors which had influence on residential areas formation, as well as the problem of decay of residential areas and the factors influencing the development of existing settlements.
Bio-Fuel in Lithuania’s Energetics: Geographical Analysis of Energy Crops and Forest Products
Authors: Bondzinskas Vaidas , Mačiulytė Jurgita
Published: October 2016

Bio-fuel, used for production of thermal energy, is one of the most important renewable energy sources in Lithuania. The use of this energy source is determined by Lithuania‘s commitments to the European Union and the energetic policy carried out by the state, which encourages the use and replenishment of renewable energy sources. The article consists of three parts, which analyze the teritorial distribution of potential biofuel resources, i.e. short-rotation energy crops, realized forest products in Lithuania‘s forestry enterprises, and use of bio-fuel for production of thermal energy for Lithuania‘s centralized heating systems in 2012.
World Hotel Industry: Selected Aspects of Its Functioning
Authors: Chudy-Hyski Dorota , Chudy Wojciech , Krutikov Valeri
Published: October 2016

The paper focuses on the development of the global hotel industry, which in the course of historical and economic changes tended towards the formation of the international hotel systems. This problem is presented against the background of the history of the development of hospitality, pointing to significant circumstances that contributed to the development of international hotel systems. The article also includes examples of international hotel systems operating around the world. The aim of the paper is to show the essence of the functioning of the global hotel industry in the context of hotel systems.
Subtleties in discrete-element modelling of wet granular soils
Authors: Duriez J. , Wan R.
Published: October 2016

The stress description provided by the discrete-element method when modelling wet granular materials is investigated for the case of low degrees of saturation within the pendular regime. The stress tensor as computed solely from contact and resultant capillary forces between individual pairs of particles is analysed in depth, being compared with an analytically derived stress expression that accounts for the distributed nature of internal actions such as the liquid pressure acting along wetted surfaces. Both fundamentally different approaches are shown to be equivalent, including for low suction values where wetted surfaces are significant and physical internal forces clearly deviate from the resultant point forces considered by the discrete-element method. Under wet conditions, it is demonstrated that the discrete-element entity now includes both a particle and half a meniscus as a unit.
Evaluation of wave loads on a new type of perforated caisson
Authors: Vázquez Miguel , Negro Vicente , López-Gutiérrez José Santos , Monsó José Luis
Published: October 2016

A new type of perforated breakwater has been tested combining the advantages of cylindrical geometry with stepped wave energy dissipation. Thus, the new type of caisson implies a significant reduction of maximum wave forces, as well as loads transmitted to the foundation in comparison with conventional vertical breakwater and other types of perforated caissons. Starting from a brief description of the model and test results, this paper describes the development of a methodology for the estimation of maximum wave loads on this type of breakwater, in order to become a generalisable tool for predesign purposes. Construction and installation constraints of this new type of caisson are also assessed. These need to be taken into account in order to keep some advantages from the proposed design, while noting the key factors from a practical point of view.
Mudanças na Gestão da Assistência Farmacêutica dos Componentes Especializados no Estado da Paraíba a partir da Implantação do HORUS
Authors: De Lima Gomes Fagner Dayan , Abrantes Fernandes dos Santos Marjorie Diony , Souto Maior Serrano Rossana Maria
Published: October 2016

Este estudo é um trabalho de pesquisa que compõe o projeto SIMSUSSistema de Informação sobre Medicamentos do SUS: acessibilidade e uso racional, e analisa o processo de organização do trabalho da Assistência Farmacêutica, e os aspectos referentes à acessibilidade aos medicamentos dos componentes especializados da Assistência Farmacêutica. É um estudo descritivo e analítico em que se descrevem as mudanças ocorridas na gestão quando da implantação do Sistema Nacional de Gestão da Assistência Farmacêutica - Hórus e analisa a pertinência das mudanças ocorridas. Como uma ferramenta basal para superar alguns dos maiores desafios para a assistência à saúde da população em todo o país, o Hórus, sistema criado pelo Ministério da Saúde em 3 de novembro de 2009, disponibiliza para todos os níveis de governo, um software que permite a integração de informações entre as farmácias, unidades de saúde e almoxarifado. O Centro Especializado de Dispensação de Medicamentos Excepcionais (CEDMEX) do Estado da Paraíba implantou o sistema Hórus em 20 de julho de 2012, e em razão dessa implantação modificou seus processos de trabalho para atender aos 23.160 pacientes cadastrados. O Centro fornece 149 medicamentos com 321 apresentações para atender a 79 patologias. O estudo busca investigar a resposta dada pela implantação do HÓRUS, os benefícios ocorridos após sua implantação, as mudanças ocorridas na gestão, os aspectos referentes aos processos de requisição e de organização do serviço. O estudo foi desenvolvido a partir da análise da literatura sobre o sistema e entrevista com os gestores envolvidos em sua implantação, bem como a análise dos documentos normativos oficiais. Mesmo considerando que o processo ainda não está concluso registram-se mudanças significativas no campo do planejamento, controle e monitoramento e da acessibilidade.
A integralidade das ações em saúde e a intersetorialidade municipal
Authors: Schuh Pauli Liane Teresinha
Published: October 2016

Com a inclusão dos contextos biopsicosocial, econômico e cultural nos conceitos do processo saúde/doença aumentaram as exigências de atuação no âmbito municipal, levando à necessidade de novos contornos no planejamento e na política. Sob a justificativa de avançar no cumprimento das normas legislativas e direcionar esforços intersetoriais capazes de garantir a integralidade das ações em saúde, objetivamos com esta investigação analisar a percepção relativa ao conceito de saúde/doença nos vários níveis da gestão pública e o relacionamento do setor de trabalho com a área da saúde, verificando a viabilidade da intersetorialidade e a percepção sobre a importância desta como estratégia para a promoção da integralidade das ações em saúde. A pesquisa realizou-se em duas etapas, com a utilização do método qualitativo de análise em ambas, por meio de entrevista individual gravada no local de trabalho (Técnica do Discurso do Sujeito Coletivo), o que possibilitou a análise dos depoimentos verbais através das ideias centrais e suas correspondentes expressões-chave. Constituíram-se como sujeitos da pesquisa todos os elementos envolvidos na gestão municipal da cidade de Vera Cruz,RS, mais dois assessores diretos de cada um destes. Observou-se que existe a concepção do conceito de saúde ampliado e positivo, há o reconhecimento da responsabilidade dos vários setores sobre o processo saúde/doença da população e a intenção do trabalho intersetorial. Concluiu-se que, com mudanças político-organizacionais, capacitação de recursos humanos e planejamento, pode-se alcançar melhoria nas ações de promoção da integralidade das ações em saúde.
A regulação do planejamento público e o conselho municipal de saúde
Authors: Barbosa Silva Oswaldo José
Published: October 2016

Apresenta-se uma visão das dificuldades que sofre o modelo de estruturação do controle social na saúde pública, por meio dos conselhos de saúde, que exsurgem de seu dever de deliberar sobre o planejamento e fiscalizar a execução das ações e serviços públicos de saúde no âmbito municipal, estabelecido que o plano de saúde e os programas anuais de saúde que lhe seguem materializam a organização que se espera para a prestação desse serviço público, que atende um direito público subjetivo de matriz constitucional. Para tanto foi feita uma revisão de literatura e uma pesquisa documental. Observou-se que falta qualificação técnica dos conselheiros paradiscutir assuntos relacionados com planejamento de saúde, financeiro e orçamentário como se pode observar em pesquisas de campo realizadas em Municípios do Nordeste Brasileiro, dos Estados de Mato Grosso e Goiás e no município de Belo Horizonte (MG). Todavia, essas deficiências não diminuem a importância do modelo de participação social adotado por meio dos conselhos de saúde, devendo ser construídas estratégias para enfrentá-las.
Inovação em saúde no Brasil: o caso das doenças negligenciadas
Authors: Madureira Amanda , Barbosa Ramos Edith Maria , Prazeres de Sena Jaqueline
Published: October 2016

O presente trabalho tem como objetivo principal analisar as interfaces entre a saúde pública e inovação para as doenças negligenciadas no Brasil. Mostra-se que a formulação de políticas públicas tem impacto no acesso a medicamentos e que o Estado deve tomar a dianteira no sentido de minorar as desigualdades existentes no sistema de inovação em relação às doenças negligencias.
O Conselho Nacional de Justiça e o direito à saúde: breves anotações sobre o Fórum Nacional do Judiciário para monitoramento e resolução de demandas de assistência à saúde
Authors: Ramos Edith Maria Barbosa , Diniz Isadora Moraes , De Sena Jaqueline Prazeres
Published: October 2016

A saúde constitui-se como direito fundamental, permeado por aspectos físicos, mentais, psicológicos, ambientais e sociais. Em razão do múltiplo caráter da saúde, a efetivação desse direito envolve uma gama de políticas, as mais variadas possíveis. Assim, o Judiciário vem recebendo uma séria de ações sobre a saúde, pleiteando diferentes tutelas. Para garantir a efetividade da prestação jurisdicional, o Conselho Nacional de Justiça, por meio da Resolução nº 107, instituiu o Fórum Nacional para o Monitoramento e Resolução das Demandas de Assistência à Saúde. Quanto aos procedimentos ou técnicas de pesquisa, que consistem em instrumentos para colher informações e para analisá-las, selecionou-se: pesquisa e revisão bibliográfica, pesquisa e revisão normativa, além de pesquisa documental. Objetivase, assim, analisar a estrutura, objetivos e políticas do Fórum Nacional do Judiciário para a Saúde, bem como traçar a racionalidade que guiou a sua criação.
Direito Ambiental do Trabalho e a saúde dos trabalhadores da pesca artesanal: estudo de caso
Authors: Carvalho Ingrid Gil Sales , Franco Rêgo Rita de Cássia
Published: October 2016

O presente tem objetiva refletir sobre o Direito Ambiental do Trabalho (DAT) na perspectiva contributiva da saúde do trabalhador da pesca artesanal. Trata-se de pesquisa bibliográfica/documental em que foram consultados documentos originais, livros, artigos, leis, projetos, regulamentos, pareceres e relatórios, utilizando-se das seguintes palavras-chave: ambiente, meio ambiente, trabalho, saúde, saudável, direito ambiental, direito do trabalho, direito ambiental do trabalho, pesca, pescador, artesão, artesanal. O Direito do Trabalho (DT) se constitui de normas específicas vinculadas à promoção da saúde e da segurança para o trabalhador e, assim como o Direito Ambiental (DA), que cuida da normatização, tanto no ambiente natural, quanto do artificial, são dois ramos do Direito Brasileiro que se sobressaem na amplitude e eficácia das normas de proteção à saúde do trabalhador. O meio ambiente de trabalho está centralizado na pessoa do trabalhador e no desenvolvimento de sua atividade laboral. O meio ambiente de trabalho é o local onde as pessoas desempenham suas atividades laborais. No caso do pescador artesanal, este se encontra imerso ao mesmo tempo no seu ambiente natural e artificial. Assim, qualquer contaminação, poluição ou dano ao meio ambiente natural afeta diretamente o pescador artesanal e, por conseguinte, a sua saúde. Evidenciou-se uma escassez na produção científica do Brasil, que aborde diálogos entre a saúde do pescador artesanal e o seu direito a um meio ambiente de trabalho saudável. Acredita-se que o DAT pode contribuir positivamente para a regulamentação da garantia do Direito à Saúde do pescador artesanal no Brasil no seu meio ambiente de trabalho.
Diálogos para efetivação do Sistema Único de Saúde de Minas Gerais
Authors: De Oliveira Silva Dayrell Ludmylla Souza , Da Silva Araújo Aline Fernanda , Faerman Rabello Vânia
Published: October 2016

Desde a promulgação da Constituição de 1988, a saúde é tratada como direito fundamental que deve ser instituído através de políticas públicas. Entretanto, não deixa de ser um direito subjetivo público, que permite ao cidadão o seu pleito, inclusive pela via judicial, quando as políticas públicas implementadas em sua região não forem suficientes. O fenômeno Judicialização vem crescendo de forma exponencial no Brasil. Minas Gerais já sofre com os impactos financeiros causados e procura minimizar os efeitos negativos dessa demanda crescente, principalmente no que diz respeito aos atrasos no cumprimento de ações que geram o desgaste do cidadão e, até mesmo, a incidência de multas por demora no cumprimento. Com base nesta premissa, foram realizados vários diálogos entre a Secretaria de Saúde do Estado de Minas Gerais, o Ministério Público e o Poder Judiciário dos quais resultou uma proposta de mudança na estrutura dos órgãos de atendimento que busca responder de forma mais eficaz e eficiente as demandas judiciais.
Saúde mental, direito e psicologia no Judiciário: interlocuções na Seção Psicossocial da Vara de Execuções Penais do Tribunal de Justiça do Distrito Federal e Territórios
Authors: Quinaglia Silva Érica , Oliveira da Cruz Mônica , De Paula Dantas Trajano Rayssa
Published: October 2016

A Seção Psicossocial da Vara de Execuções Penais do Tribunal de Justiça do Distrito Federal e Territórios ocupa-se do atendimento a pessoas que cumprem medida de segurança, ou seja, uma sentença judicial que as define como doentes e criminosas. Este trabalho visa entender os caminhos percorridos por essas pessoas, quais sejam a internação e o tratamento ambulatorial, e verificar como têm se configurado as interlocuções entre saúde mental, direito e psicologia no judiciário.
Formatação dos processos judiciais que demandam medicamentos no Município de João Pessoa-PB, 2009-2012
Authors: Alves Gabriel Rildeane , Helena Dantas Sabine , Souto Maior Serrano Rossana Maria
Published: October 2016

Esta pesquisa é parte do projeto SIMSUS - Sistema de Informação sobre Medicamentos do Sistema Único de Saúde: acessibilidade e uso racional. Faz-se uma análise dos elementos que compõem os processos judiciais que demandam aquisição de medicamentos no município de João Pessoa. A pesquisa foi realizada na Gerencia de Medicamentos do Município de João Pessoa (GEMAF); foram analisados todos os processos judiciais que demandavam a aquisição de medicamentos nos anos de 2009 a 2012. Para a coleta de dados foi estruturado um roteiro com questões referentes a: perfil do usuário (idade, sexo, região onde reside) e perfil do processo judicial (documentos que o compunham e existência, nos autos, de laudo médico, exames, o código da Classificação Internacional de Doenças (CID)). As informações foram sistematizadas em razão da composição do processo judicial e da natureza farmacológica do produto solicitado. Foi constatada a falta de um padrão na estruturação dos processos e a ausência frequente de informações fundamentais para análise da pertinência farmacológica do medicamento. Evidenciou-se que grande parte dos processos não trazia informações sobre a idade do usuário, a CID ou a duração do tratamento. Concluiu-se pela necessidade de articulação entre o Gestor Municipal e o Poder Judiciário sobre a padronização das informações dos processos judiciais, nos aspectos formais de composição do processo.
O período de tempo para guarda dos processos clínicos e exames
Authors: Marchesini Stival Sephora Luyza , Ferreira Ramos Manuel Flores
Published: October 2016

No que refere o tempo de conservação dos documentos clínicos, a legislação em Portugal é esparsa, com referências sobre a conservação em diversos diplomas legais, o que contribuiu para o desconhecimento de grande parte dos profissionais da saúde e gestores de instituições de saúde o período em que encontram-se obrigados a conservar as informações dos seus pacientes. Já no Brasil apesar da ausência legislativa o Conselho Federal de Medicina, através de Resoluções vem consolidando a temática. Ambos os países encaminham-se a favor da guarda permanente, que só pode ser alcançada através da mudança do suporte de papel para o suporte eletrónico.
The Good Capitalist: Conflicting Visions of Russia’s Industrial Future in the Pre-Reform Period
Authors: Smith-Peter Susan
Published: October 2016

В статье рассматриваются дискуссии о промышленном будущем России среди дворян, купцов и чиновников Владимирской губернии до реформы 1861 г. В дискуссиях сформировались два различных взгляда на будущее России. Первый представлял Россию урбанистической, индустриализованной, фабричной страной, с хлопкообрабатывающей промышленностью в роли гаранта экономической независимости. Второй вариант предполагал, что Россия останется сельской страной, но развитие науки и совершенствование сельского хозяйства преобразят льнопереработку и помогут деревенским общинам выжить и после индустриализации. И дворяне, и купцы полагали, что могут быть «мудрыми отцами» для народа будущей индустриализованной России. Анализ статистических материалов, опубликованных в губернских ведомостях, показал, что они могут служить новым источником информации о том, как еще до отмены крепостного права в России воспринимали индустриализацию и социальные перемены.
Концепты воспитания: доступность понимания ключевого понятия и стереотипность его оценивания
Authors: Ситаров Вячеслав Алексеевич
Published: October 2016

Неоднозначность представления педагогики как науки в массовом сознании — от упрощенного эмпирического понимания до излишнего теоретизирования, доводящего педагогическое знание до уровня схоластической догматизации, — не позволяет найти какие-либо единые подходы в реализации воспитания. Традиционное понимание образования как целостного процесса единства обучения и воспитания определяет стереотипность критериев оценивания того и другого. Современному работнику образования традиционно вменяются обе функции — обучающая и воспитывающая.

Существующая формула оценивания результативности по формуле «здесь и сейчас», применяемая в обучении, в воспитании не работает. Данная статья обращает внимание читателя на некоторые «поправки», которые необходимо учитывать в воспитательной работе. Во-первых, доступность в понимании педагогической категории «воспитание», а значит, и вольная его трактовка, не упрощает организации процесса воспитания во всех его ипостасях, но, напротив, намного усложняет его и требует согласованных действий всех субъектов и объектов различных педагогических воздействий. Во-вторых, как следствие из первого, неоднозначное толкование понятия «воспитание», не позволяет иметь одинаковые для всех критерии и показатели оценивания воспитательной работы.
Дискуссия вокруг подражания языку Шекспира в английской культуре в последней трети XVII — начале XVIII в.
Authors: Кузьмичев Арсений Игоревич
Published: October 2016

Вторая половина XVII в. в Англии — время доминирования французской литературной критической школы, которая в первую очередь видела в произведениях искусства образцы для подражания и воспитания новых поколений аристократов. Шекспир, изображавший на сцене убийства и другие злодеяния, и речи героев которого нередко не соответствовали их социальному статусу плохо подходил на роль воспитателя. Вкус эпохи гораздо больше благоволил к творческому дуэту Фрэнсиса Бомонта и Джона Флетчера, уделявшему серьезное внимание связности сюжетов пьес и изображению правильных манер и поступков.

В это же время впервые актуализировалась проблема совершенствования языка. Ее вероятным катализатором стало сочинение Самюэля Сорбьера о путешествии в Англию (1664). Английские интеллектуалы видели два способа ее разрешения: отстаивание культурной самобытности с опорой на язык третьего сословия и подстройка своего культурного наследия под главенствующие нормы эпохи. Вначале был выбран второй путь, автор статьи иллюстрирует его на примере шекспировских пьес.
Однако в конечном счете возобладало представление о преимуществе языковой модели третьего сословия, отстаиваемое историком Лондонского королевского общества Томасом Спратом и первым английским литературным критиком Томасом Раймером. Последний в выработке своей точки зрения прямо опирался на язык шекспировских пьес. При этом в эпоху Реставрации их аргументация оказалась невостребованной, и лишь во второй половине XVIII в. последующие поколения интеллектуалов смогли утвердить эту модель в качестве основной, тем самым поставив Шекспира в центр новообразованного канона английского языка.
М. В. Ломоносов — историк
Authors: Алешкин Петр Федорович
Published: October 2016

Рецензия на издание: Васильев Ю. А. М. В. Ломоносов в русской исторической школе. — М. : Изд-во Моск. гуманит. ун-та, 2016. — 168 с. 
Культурное пространство территории как ресурс экономики впечатлений
Authors: Новосельская Вера Вадимовна
Published: October 2016

В статье рассматриваются основные аспекты и возможности экономики впечатлений в развитии территории посредством использования ее культурного потенциала. Предполагается, что механизмом сближения экономики и культуры является трансформация понятий «культурный ресурс» и «культурная ценность».

Понятие культурного пространства рассматривается через призму концепции экономической ценности и культурного ресурса Д. Тросби, где культура выступает «катализатором» возрождения определенной территории, создавая как прямую, так и косвенную экономическую ценность. В данном контексте проводится параллель между культурным потенциалом территории, ее устойчивым развитием и новой ролью культурного наследия, заключающейся в формировании и сохранение культурной и национальной идентичности, которое, кроме всего прочего, выступает определенным культурно-экономическим активом. Таким образом, культура понимается как капитал, являющийся источником культурных благ, ценностей и услуг, ресурсы которого невозможно полностью исчерпать.

Отмечается, что экономика впечатлений является современным продуктом развития культуры. Именно впечатления чаще всего являются основой культурных индустрий и сферы развлечений, сопровождая производство и потребление любого культурного продукта, они всегда личностны и строятся на узнавании или приобщении к чему-то величественному, например к культурному наследию, культурным ценностям той или иной территории, региона. Впечатления лежат в основе феномена, получившего название «бренд территории», так как являются «ядром» популярности того или иного места, города, региона или страны в целом. Предполагается, что в современном мире одной из функций территории стало производство впечатлений как фактора ее успешного не только культурного, но и экономического развития. Впечатления стоят дороже услуг, так как их ценность невозможно свести к экономической выгоде.

В исследовании приводятся примеры успешной продажи и использования впечатлений в своей деятельности отечественными и зарубежными культурными и туристическими объектами. Показывается ценность впечатлений как персонализируемого товара, отмечается, что именно они обеспечивают успех компаний и лежат в основе экономических, социальных и культурных стратегий территориального развития.
Ценностный выбор российского общества как проблема культурной самоидентификации
Authors: Жукова Ольга Анатольевна
Published: October 2016

Статья посвящена проблеме исторического самопознания современного российского общества. Цивилизационное самоопределение нации, считает автор, формируется в результате освоения отечественной истории, извлечения уроков из социальных катастроф ХХ в. Наследование социального опыта прошлого возможно как актуализация культурных ценностей, выработанных в рамках отечественных религиозных, художественных, политических традиций. Российскому обществу следует расширять дискурсивные практики культурно-исторического знания, а вместе с тем и публичное обсуждение истории и культуры. В статье рассматриваются два вектора развития этой ситуации — образовательный и культурный.

Особенно остро стоит вопрос о понимании и представлении молодого поколения о самих себе, о ценностном наполнении их жизненного опыта, об отношении к истории своей страны и наследию национальных культур. Автор приводит результаты социологических исследований, которые проводились им в течение шести лет (2006–2012 гг.) со студенческой аудиторией первого курса Института управления и экономики промышленных предприятий Национального исследовательского технологического университета «Московский институт стали и сплавов». Результаты исследования показывают, что студенческая молодежь продолжает воспринимать историческое прошлое страны как живую часть культурного опыта современного российского социума, признавая духовное и художественное наследие своеобразной гарантией развития исторического самосознания — условием движения к будущему.

Эта тенденция в последнее десятилетие развивается с общей линией государственной культурной политики по восстановлению исторической преемственности и сохранению культурного наследия. Анализируется политика государства в области образования и культуры, использование современного инструментария мультимедиа в просветительских целях, актуальные формы организации музейно-выставочных пространств, которые становятся  интеллектуальными площадками для выработки общенациональной идеи. Споры об интерпретации истории, возможности единого учебника и пр. обозначают болевые точки исторического самочувствия нации. 
Reflexiones sobre la G. Correas a propósito de la edición de su Arte Kastellana
Authors: Martínez Gavilán María Dolores
Published: October 2016

Reflexiones sobre la G. Correas a propósito de la edición de su Arte Kastellana
studio del Comportamiento Dinámico del Diseño de Sistemas de Información basado en Redes Complejas
Authors: Pagani Jorge Benjamín
Published: October 2016

La Ingeniería del Software requiere de métricas adecuadas para dar soporte a la toma de decisiones técnicas y de gestión en el proceso de desarrollo de software. Se han desarrollado cientos de métricas hasta el momento pero el área de métricas de software todavía no se encuentra en un nivel de madurez adecuado para una disciplina sistémica y cuantificable como la Ingeniería del Software. Esto se debe principalmente a que la mayoría de las métricas desarrolladas no proveen la información necesaria de forma oportuna y precisa. En este artículo el autor propone una metodología de análisis dinámico del diseño de sistemas basada en redes complejas, consistente en el modelado del diseño de sistemas como una red compleja y en el cálculo de métricas sobre dicho modelo.
Análisis Comparativo de Algoritmos de Minería de Subgrafos Frecuentes
Authors: Bianco Santiago
Published: October 2016

Gracias a las posibilidades que ofrecen a la hora de representar información y la abstracción conceptual que permiten manejar, los grafos son ampliamente utilizados en investigaciones relacionadas con la informática. A medida que se fueron incrementando las aplicaciones de estas estructuras, la complejidad de los elementos a representar y el volumen de información manejado, aparece la necesidad de utilizar procesos eficientes para extraer información o patrones ocultos en esa gran masa de datos, por lo que se comienza a aplicar la minería de grafos. Dentro las técnicas de minería de grafos se encuentra la búsqueda de subgrafos frecuentes, utilizada para reconocer subestructuras comunes entre un conjunto de grafos. En los últimos años se han llevado a cabo varias investigaciones que resuelven este problema, generando algoritmos diversos aplicando distintos enfoques, entre los cuales se encuentran el FSG, FFSM, gSpan y GASTON. El objetivo de este artículo es analizar el comportamiento de estos algoritmos a través de distintos experimentos diseñados para identificar si existe un algoritmo superior al resto y, en caso de que no lo haya, poder definir en qué escenarios es más recomendable la elección de cada uno.