bluuebunny/crossref_metadata_2025 huggingface dataset:
PO-289 Lipidomic analysis of blood serum from prepubertal boys with different BMI
Authors: Cao Yuping , Yan Yi , Xie Minhao
Published: October 2018

Objective Childhood obesity is a worldwide health problem which may causes metabolic diseases such as hyperglycemia, hyperlipidemia, hypertension and hyperuricemia. It is well know that lipid metabolites regulate fatty acid and glucose homeostasis. Lipidomics is the comprehensive analysis of lipid metabolites which include their quantitation and metabolic pathways. The intention of this study is to identify the circulating lipid species which are altered in obese prepubertal boys.

Methods A total number of 72 boys aged 10.28 ±0.69 years old were included into this study, and divided into normal(NC), overweight(OW) and obese group(OB). The degree of maturation of all boys were measured by bone age and sex hormones. Then we measured the form indexes, blood lipids, blood glucose level to identify the current state of all boys. Serum indexes were detected by CLIA and ELISA methods. A lipidomic method was established by using a Waters Acquity UPLCI-Class liquid system combined with Waters Xevo G2-SQ-TOF mass spectrometry system. The identification and analysis of lipid metabolites were complished by using MassLynx 4.1, Progenesis QI software and LipidMaps database. Statistical analyzes were performed using SPSS22.0 software.

Results (1)The waist-to-hip ratio, bone age and HDL-c levels ware significant lower in OW and OB groups. The TG level was significant higner in OB group. The DHEA and SHBG levels was significant higner in OW and OB groups and the other sex hormones are not .

(2) In this study, 153 most significant different lipid metabolites were founded, incluing 3 diacylglycerol, 32 triglyceride, 1 Phosphatidyl cholines, 1 Phosphatidylinositol, 3 Sphingomyelin, 1 Ceramide which significant higher in OW&OB group; 4 diacylglycerol, 17 Phosphatidic acid, 32 Phosphatidyl cholines, 4 Phosphatidylinositol, 13 Phosphatidylserine, 18 Phosphatidyl ethanolamine, 3 Phosphoglycerides, 13 Sphingomyelin and 6 Ceramide which significant lower in OW&OB group.

Among all this metabolites, 8 lipids (fold change ≥5) were founded as the significant biomarkers related prepubertal obesity , including 1 Phosphatidyl cholines, 1 phosphatidylserine, 2 sphingomyelin and 4 Triglyceride. What’s more, the level of SM(d16:1/24:0) and TG(15:0/17:1/20:3) which measured by UPLC-QTOF/MS are highly positive correlated with the level of serum SHBG; PC(18:0/0:0) and TG(16:1/18:0/20:3) are highly negtive correlated with serum SHBG.

Conclusions Overweight and obese prepubertal boys showed disorder in lipid metabolism and bone growth. The lipidomic results showed lower SHBG level is related with the disorder of lipid metabolism. We suggest that further studies on these metabolites could help us gain a better understanding of the relationship between obesity and growth disorder.
PO-290 Discussing and Exploring about Mobile Quick Recovery Strategy for General Games——Quick Recovery Measure Applied on the 13th National Games
Authors: Liu Yong , An Jianghong
Published: October 2018

Objective Multiple quick recovery methods are used in the training and competition fields to explore quick recovery programs appropriate for application at the competition site, search for quick recovery form appropriate for competition characteristics of partial programs, and provide more science and technology measures for preparing for large sport, quickening the recovery of the athletes at the competition site, improving competitive capability and enhancing training and competition performance.

Methods Athletes in Beijing participating in partial programs of the 13th National Games are taken as the research object. According to training and competition characteristics of the program, and in combination with competition rules and conditions at the competition site, practice research is used to try to use nutritional supplement, whole-body cryotherapy (WBC), hyperbaric oxygen recovery, deep muscle stimulate (DMS), intermittent pneumatic compression (IPC) and music therapy and others at the training and competition sites, explore positive and effective quick recovery solutions, and establish a mobile quick recovery strategy for general games.

Results According to research results of all events in Beijing before the game, nearly 70% of sports teams are in urgent need of corresponding quick recovery support and guarantee; it’s proven through practice and application in the 13th National Games, mobile quick recovery strategy can be used during preparation before the game, so as to activate the muscle in an accelerated way, improve nerve excitability and enhance warm-up effect; in the break of many matches in one day, it can be used to calm down, quickly supplement energy substances, speed up the elimination of metabolites, relieve muscle fatigue, quickly restore physical functions, and prepare well for the next match; if competition is required in consecutive days, it can be used during recovery after the end of daily competition, to timely supplement energy substances consumed in competition, eliminate metabolites, improve sleep, accelerate anabolism, fully restore physical functions and ensure good state in the competition

Conclusions With the principle of quickening muscle relaxation and fatigue elimination and in the form of “quick recovery mobile service station”, during preparation before competition, interval and after the competition, mobile quick recovery strategy can be used, i.e. multiple quick recovery measures are used at the competition site to promote fatigue elimination and physical recovery of the athletes, achieve good results, provide strong operability and good promotion value, so as to provide a new thought and selection for preparing for large games, speeding up recovery of athletes at the competition site, improving competitive capability and enhancing training and competition performance.
PO-291 Applied Research on Enhancing Respiratory Muscle Strength of Synchronized Swimmers by Using Respiratory Muscle Trainer
Authors: An Jianghong , Fan Yuncai
Published: October 2018

Objective  In research to date , powerbreath training to be tested were useful to improve the athletics’ ability for training the breathe muscles, by the way to optmizing the Breathing technique.To further improve the synchronize swimming athletes’ powerbreath of BeiJing,tenhancing the athletics level and express ability of whole team, to succeed in the finals.

Methods Six synchronize swimming athletes were the subjects of our research,the training takes place after the strength training,two times per week, 10 times of five weeks.the training frequency were 24~32 per minutes.At this stages we tested the changes of the breathe muscle by use the CHEST H-101 and Powerbreath K3  before and after the training.All the data were analyzed using SPSS17.0 software.

Results The research results shows, training the breathe muscle by spirotiger is the useful training methods to improve the synchronize swimming athletes’s powerbreath.By five weeks training,the synchronize  swimming athletes’ lung volume capacity were significantly increased from 4.38L to 4.54L after powerbreath training, the rate of the enhancing were 3.65%、 FVC were significantly increased from 3.80Lto 3.93L after powerbrath training, the rate of the enhancing were 2.89%、MVVwere significantly increased from 122.2L/min to 127.1L/min, the rate of enchancing were 4.0%, the strength of inspiratory muscle were significantly increased from 110.6cmH2O to 125.6cmH2O, the flow of inspiratory muscle were significantly increased from 6.2L/S to 6.8L/S. All the datas shows that the power of the breathe muscles were enhancing efficenicy after five weeks systematic training,and the variation rate of individual research shows that there were difference between the individuls.

Conclusions After five weeks systematic breathe muscle training,FVC and MVV were significantly increased ,shows the synchronize swimming athletes’ respiration muscle strength were significantly increased; the index were significantly increased of the strength of  inspiratory muscle also shows that the breath muscle training were enficiency,and the training plan is helpful to enhancing the synchronize swimming athletes’ powerbreath.
PO-292 Exercise Delays Alzheimer's Disease Through Enhancing Lysosomal Function
Authors: Lin Fang , Wang Xue , Huang Jun , Zhu Yu Ting , Qin Zheng Hong , Li Zhe
Published: October 2018

Objective Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by aggregation of amyloid-β (Aβ) peptides. Reduction of progressive accumulation of Aβ will delay the progression of AD. As a main digestive organelles in cells, lysosome is crucial to clear the harmful proteins from extracellular and intracellular. Recent evidences have shown that exercise improves cognitive function of AD, but the reason is not very clear. This manuscript is to study the effect of long-term running exercise training on lysosomal function in mouse brain and explore its relationship with the progress of Alzheimer’s disease.

Methods  the APP/PSEN1 transgenic mice were used as the AD model to examine the relationship between AD, exercise and lysosomes.  The mice were trained on a treadmill from the 5 months old, 60 min/day and 5 days/week for 5 months. The Lashley water maze and the novel object recognition test were used to estimate the cognitive ability of the mice; the balance beam and the rotating rod experiment were used to estimate motor coordination. The Aβ accumulation was measured with brain section and immunochemistry. The effects of long-term exercise on lysosomal function of cerebral cortex, striatum and hippocampus were measured. Among them, the autophagy/lysosome associated proteins level was determined by Western blot and the autophagy vacuoles and lysosome were observed through electron microscope. TFEB nuclear translocation was determined by Western blot and Immunofluorescence. The transcription of the TFEB-regulating genes were determined by quantitative PCR (qPCR).  

Results Long-term exercise improved the cognitive ability and physical coordination of AD transgenic mice. Exercise reduced Aβ accumulation through increase the clearance of Aβ and affected little on the production of Aβ. Exercise, not only increased the colocalization of lysosomes with Aβ, but also increased the mature type of lysosomal protease cathepsin D and cathepsin L. In the meanwhile, exercise promoted the nuclear translocation of TFEB, a master transcriptional regulator of lysosomal biogenesis and autophagy, and increased the transcription of genes associated with the biogenesis of lysosome.

Conclusions Long-term exercise training delays the progress of Alzheimer's disease through activating function of lysosome and enhancing the biogenesis of lysosome. Exercise may be a therapeutic approach for the treatment of Alzheimer's disease.
PO-294 Effects of HIIT on FTO protein expression and its relationship with glucose and fat metabolism
Authors: Xu Chunyan , Zhao Juan , Duan Jiayan
Published: October 2018

Objective FTO (Fat mass and obesity-associated) is associated with increased risk of obesity and type 2 diabetes incurrence. Studies have shown that the expression of FTO protein in skeletal muscle and adipose tissue is related to the oxidation rate of whole body substrate. With the increase of age, the body's carbohydrate oxidation rate decreases, the fat oxidation rate increases, and at the meanwhile the expression of FTO protein in skeletal muscle decreases and that in adipose increases. HIIT is very helpful for inhibiting obesity, insulin resistance and type 2 diabetes. So the purpose of this study is to investigate the effect of HIIT exercise on the expression of FTO protein in rats and its relationship to glucose and fat metabolism.

Methods 20 Male, 3-week-old SD rats were randomly divided into two groups, each group has 10 rats. C group: sedentary; HIIT group: high-intensity intermittent training group (85% ~ 90% VO2max exercise for 6min, 50% VO2max exercise interval 4min, repeated 6 times. 5 times/week ,4 weeks). All subjects were maintained in a free facility with constant temperature of 25°C, light-dark cycle of 12/12 h and free access to water. 48 hours after the last exercise, all samples were taken with an overnight fast. The expression of FTO protein in skeletal muscle and adipose tissue was measured by Western Blot. Serum insulin was tested by ELISA; Estimation of blood glucose was tested by Glucose oxidase method.

Results 1.The expression of FTO protein in skeletal muscle was significantly higher than that of group C (P <0.01); The expression of FTO protein in adipose tissue of HIIT group was significantly lower than that of group C (P <0.05); 2. Serum insulin levels of group HIIT was significantly lower than that of group C (p <0.01); And the blood glucose of group HIIT was significantly lower than that of group C (p <0.01). 3. Serum LDL-C of group HIIT was significantly lower than that of group C (p <0.01), and serum HDL-C of group HIIT was significantly higher than that of group C (p <0.01);4. Correlation analysis showed that serum insulin level was negatively correlated with skeletal muscle FTO protein expression (R = -0.454, p < 0.05). Correlation analysis showed that serum LDL-C levels was positively correlated with adipose tissue FTO protein expression (R=0.559, p < 0.05) and serum HDL-C levels was negatively correlated with adipose tissue FTO protein expression (R=-0.474, p < 0.05).

Conclusions 1. HIIT can increase the protein expression of FTO in rat skeletal muscle and decrease the expression of FTO protein in adipose tissue; 2. HIIT can regulate glucose metabolism and lipid metabolism in rats; 3. The regulation of glucose metabolism by HIIT may be related to the increase of FTO protein expression in skeletal muscle. The regulation of lipid metabolism may be related to the reduction of FTO protein expression in adipose tissue.
PO-296 Sex differences in the change of amino acid and cortisol concentration after marathon race
Authors: Zhou Chunhua , Li Meng , Chen Song , Du Yutao
Published: October 2018

Objective As we all know, marathon exercise can induce dramatic changes in amino acid and hormone concentration in the plasma. However, little attention has been given to the role of sex in metabolic changes.

Methods We compared the changing rates of amino acid and hormone after marathon running in male and female runners. Twenty-seven female (mean age: 41±15 years) and 66 male (mean age: 40±16 years) non-professional runners performed a marathon race. Amino acid and cortisol levels were assessed before and at 1h after race.

Results At pre-race and post-race, cortisol concentrations in female runners were lower than in males. Cortisol increased in all subjects at post-race but the rising rate was substantially higher (P<0.05) in females [median (range): 3.5 (21~ -0.25)] than in males [median (range): 2.09 (14.3~-0.43)]. Post-race, the glycogenic amino acid concentrations of Arg, Asn, Gly, Ile, Met, Ser and Thr were significantly decreased in females and males. But females have higher decreased rate (P<0.02) [median (range):Arg -45% (12%~ -69%), Asn -42% (25%~ -72%), Gly -45% (5%~ -73%), Ile -35% (16%~ -64%), Met -28% (48%~ -62%), Ser -34% (17%~ -58%), Thr -33%(32%~ -52%)] than males [median (range):Arg -35% (65%~ -64%), Asn -29%(46% ~ -59%), Gly -33% (13%~ -64%), Ile -23% (37%~ -57%), Met -14% (92%~ -52%), Ser -23% ( 21%~ -56%), Thr -17% ( 84%~ -58%)]. This is because, during exercise, cortisol has the function of inducing gluconeogenesis to maintain plasma glucose supply.

Conclusions There is significant sex differences in the change of cortisol and some glycogenic amino acid concentration before and after marathon race, which has potential value for training and nutrition supplement in marathon running.
PO-298 Effect of exercise and Siyeshen upon hippocampal cytochrome c and caspase-3 of diabetic rats
Authors: Wang Dongmei , Zhang Jinming , Liu Haibin , Wang Rongmei
Published: October 2018

Objective To observe the effects of aerobic exercise and Siyeshen water extract on cytochrome c (Cyt c) and caspase-3 in hippocampus of diabetic rats and to explore the possible mechanism of improving diabetes.

Methods Healthy male Wister rats fed with high fat and high sugar and combined with streptozotocin to establish type II diabetes model. They were randomly divided into 4 groups: diabetic control group, exercise group, Siyeshen group and exercise+Siyeshen group, and another normal control group, with 6 rats in each group. After aerobic exercise (15m/min, 5°slope, 60min, every other day) or/and Siyeshen (200mg/kg) gastrointestinal administration for 8w, the expression of Cyt c and caspase-3 in hippocampus of each group were detected by immunoblotting, and mRNA expressions were detected by RT-PCR.

Results Compared with the normal control group, the mRNA and protein expressions of Cyt c and caspase-3 in the hippocampus of the diabetic control group were significantly increased (P<0.05). Compared with the diabetic control group, the blood glucose level of exercise group and exercise+ Siyeshen group decreased (P<0.05), the mRNA and protein expression of Cyt c and caspase-3 decreased significantly (P<0.05), but there were no significant changes in the mRNA and protein expression of Cyt c and caspase-3 between Siyeshen group and diabetic control group (P﹥0.05).

Conclusions Exercise and exercise combined with Siyeshen can inhibit cytochrome c release and reduce caspase-3 protein expression, which may be related to the improvement of blood glucose levels in diabetic rats.
PO-208 Effect of resistance training on functional fitness and bone mineral density in elderly women
Authors: Sun Jinqiu , Tan Jingjing
Published: October 2018

Objective Try to carry out the intervention experiment of the strength exercise of the elderly in the community, aiming to provide theoretical and data basis for the daily strength exercises of the elderly in China.

Methods  Recruiting 18 elderly female volunteers in Xicheng District, Beijing, required independent living ability and were willing to participate in the experiment. They were randomly divided into intervention group (N=9, 62.0±6.0 years) and control group (N=9, 63.0 ± 4.8 years). On Tuesday afternoon and Thursday morning, under the leadership of a professional coach, follow the planned "Resistance Exercise Plan" to carry out resistance training. Each practice time is about 90min for 9 weeks. The exercise intensity control is divided into two phases: the first phase lasts for one week, mainly the learning and adaptation phase of the action, and the heart rate control in the 30%~40%HRR or RPE 10 subscale is 4 (a little easy); The stage lasts for 8 weeks of the medium-intensity practice phase, the heart rate control in the 40%~60%HRR or RPE 10 subscale is 5~6 (moderate, slightly strenuous).

Results Intervention group before and after experiment, the grip strength (25.0±5.0 VS 26.8±3.9 kg, P<0.05) and the 30s arm curl test (23.1±5.2 VS 25.4±4.0 reptitions, P<0.05) increased. Five sit-up tests (6.99±2.01 VS 6.51±2.00 s, P<0.05) and the 8-foot standing walk (5.13±1.03 VS 5.07±1.01 s, P<0.05) were all shortened. The bone density T value (-1.3±0.4 VS -1.0±0.4, P<0.05) increased. After intervention, the intervention group compared with the control group, grip strength (26.8 ± 3.9 VS 22.1 ± 4.5 kg, P <0.05), 30s arm curl test(25.4 ± 4.0 VS 22.1 ± 3.0 reptitions, P <0.05) increased. Five sit-up tests (6.51 ± 2.00 VS 6.94 ± 1.05 s, P < 0.05) and 8 feet of standing walk (5.07 ± 1.01 VS 5.27 ± 0.97 s, P < 0.05) were all shortened. Bone density T value (-1.0 ± 0.4 VS - 1.4 ± 0.4, P < 0.05) increased. There was no significant change in the 30-second chair stand test.

Conclusions Through 9 weeks of progressive resistance exercise, the experiment made the upper limb explosive force, upper limb muscle endurance, lower limb explosive power, flexibility and dynamic balance enhanced, and bone density increased. The enhancement of lower limb endurance is not obvious, which may be the reason for short experimental time and small exercise intensity of lower limbs.
PO-219 Experimental study on exercise intervention to improve cardiac risk during exercise in men aged 40~49 years
Authors: Huang Jianya , Cao Jianmin , Xie Minhao , Lin Jiashi , Li Sen , Tang Qiang
Published: October 2018

Objective Through 12 weeks exercise interventions of different exercise volume (1200kal/w or 2000kcal/w) on 40-49 years old male subjects，trying to explore the effect of exercise intervention on the d risk indicators of ECG (ST、QTcd) during the exercise, to provide a scientific basis for the public health in the future .

Methods The subjects were randomly divided into 3 groups. (1)control  group (n=9); (2) low volume group (n=7); (3) high volume group (n=8). The exercise group exercise intervention lasted 12 weeks. The indices of HRV at rest and risk indices of ECG (ST、QTcd)during exercise.

Results  (1) Compared the underdraught of ST segment during exercise before and after the intervention, we found that exercise intervention did not produce significant change, and QTcd during the exercise in both high and low volume group after the intervention was significantly lower than before (P <0.05). (2) Compared the difference of ECG indices during exercise before and after, we found that descender of QTcd in low volume was significantly higher than the control group (P<0.05), while the descender of QTcd in high group was very significantly higher than the control group (P<0.01). The difference of ST segment in different group did not have significantly change.

Conclusions (1) 12 weeks exercise intervention (intensity of 65-80% VO2max, exercise volume of 2000kcal/w) has no effect under the pressure amplitude of the ST segment during the exercise. (2) 12 weeks exercise intervention (intensity of 65-80% VO2max, exercise volume of 2000kcal/w) produce QTcd during exercise significantly reduced, reducing the risk of exercise-induced myocardial ischemia.
PO-222 The Influence of Different Route Randomness on Energy Contributions of College Students' Badminton Running Practice with Change of Direction at Two Frequencies
Authors: Wang Xinxin , Shi Fuying , Wei Jia , Li Bo , Li Xiaotian , Jin Lu , Li Yongming
Published: October 2018

Objective Badminton four-corner running practice with change of direction commonly includes fix route and random route. However, the study of the energy contributions characteristics of these two training methods was very limited. The aim of this study was to investigate the influence of different route randomness on energy contributions of college students' badminton running practice with change of direction at two frequencies.

 

Methods 15 college badminton player whom from Shanghai University of Sport (Male, N=15, 22.9±1.4 yrs, 175.7±6.0 cm, 68.0±6.4kg, badminton training experience 2.2±0.5 yrs) volunteered to perform one test for maximal oxygen uptake （VO2max） on treadmill and four field tests with two route randomness (fix route and random route, F and R ) and two frequencies (24 times per 1min and 24 times per 1min, H and L ) of change of direction. A portable spirometric system (K4b2, Cosmed, Italy) was utilized to measure the ventilator information during the test, and capillary blood was taken from earlobe and analyzed prior and post the tests. The energy contributions was calculated with the method based on the fast component of oxygen debt (WAla) , accumulated blood lactate (WLa) and VO2 (WAer)during the tests.

Results Higher frequency significantly increased the energy contributions from the three pathways both with F and R (WAla:26.2±6.3 kJ vs. 39.5±12.6 kJ, WLa: 5.7±2.4kJ vs. 23.1±9.3 kJ, WAer: 27.1±6.5kJ vs. 33.3±5.7kJ, P<0.01), and significantly increased the WLa (F: 23.9±8.1% vs. 9.6±3.4%, P<0.01; R: 30.5±6.6% vs. 11.7±5.2%, P<0.01), whereas significantly reduced the WAer% (F: 35.2±6.5% vs. 46.0±8.5%, P<0.01; R: 35.7±5.4 % vs. 50.4±10.2%, P<0.01). The R significantly reduced the WLa% both in L (44.4±8.5% vs. 38.0±8.6% , P<0.05) and H (40.9±10.5% vs. 33.8±8.6%, P<0.05), significantly increased the WLa (23.1±9.3kJ vs. 28.9±7.3kJ, P<0.05) and WLa% (23.9±8.1% vs. 30.5±1.7%) in H.

Conclusions The route randomness of badminton running practice with change of direction at two frequencies has different effects on the energy contributions. The R will reduce the stimulation to the WAla and increase the stimulation to the WLa ; the H will increase the intensity of the running with change of direction as a whole, and will reducing the stimulation to the WAer and increasing the stimulation to the WLa. It is recommended that the coaches can change the stimulation of the WLa by changing the frequency of the change of direction and the randomness of the route when design the badminton four-corner running practice with change of direction.
Facilitative and hindering factors regarding the supervisory relationship based on supervisors’ and undergraduate supervisees’ opinions
Authors: Meydan Betül
Published: October 2018

The purpose of the present study was to examine Turkish counseling supervisors’ and undergraduate supervisees’ opinions about the supervisory relationship. Upon completion of Individual Counseling Practice course, semi-structured individual interviews were conducted with four voluntary supervisors (two female and two male) and their four voluntary undergraduate supervisees (four female) in a case study design. Content analysis results revealed three main categories of supervisors’ and supervisees’ opinions on the supervisory relationship: a) facilitative factors, b) hindering factors, and c) effects. The findings were discussed in the light of the relevant literature and recommendations regarding developing strong supervisory relationship with undergraduate supervisees are presented.
Sto lat metody projektów w Polsce
Authors: Pogorzelska Marzanna
Published: October 2018

A Hundred Years of the Project Method in PolandThe text presents the development of the project method in Polish education throughout the last century. The project method was introduced into Poland after regaining independence, and it was implemented during the inter-war period (1918–1939) in some schools, both in urban and rural environments. Nevertheless, the method was at that time treated as a pedagogical novelty andexperiment, rather than a natural part of school life. After 1945, education, like other aspects ofsocio-political life, was influenced by the communist propaganda, and the project method, supporting autonomy, democracy and empowerment, was not promoted as a valuable educational approach. After 1989, when progressive trends appeared in Polish schools, the project method gained somepopularity but it was not until 2008 when it was granted national and formal recognition. Then, the new core curriculum was developed, and the project method became an obligatory part of school reality. The revival of the project method was connected with the alarming findings concerning social capital in Poland. In this situation, making students cooperate within projects seemed aremedy for the decreasing social capital. As the author points out, formal introduction of the method does not necessarily mean its effective accomplishment, which should be accompanied by spontaneity and authentic engagement. What is more, as the author shows, after decades of theabsence of this method in Poland, and the lack of the relevant socio-cultural background, teachers might find it difficult to implement a project so as to contribute to the increase of social capital. All these areas need further investigation. Nevertheless, the author hopes that the text will contribute tobetter understanding of contemporary challenges and opportunities related to the implementation of the idea of projects in Polish education.
Kierunki badań prowadzonych przez pracowników Zakładu Historii Nauki, Oświaty i Wychowania Instytutu Pedagogiki Uniwersytetu Gdańskiego
Authors: Śpica Paweł
Published: October 2018

.
Recenzja książki Władysławy Szulakiewicz pt. Nauczyciele i ich edukacja. W kręgu idei lwowskiej pedeutologii, Wydawnictwo Uniwersytetu Mikołaja Kopernika w Toruniu, Toruń 2027, 337 s.
Authors: Chmielewski Witold
Published: October 2018

.
Nauczyciele wychowawcy polskich szkół salezjańskich w okresie od 1898 do 1939 roku
Authors: Wierzbicki SDB Mirosław Stanisław
Published: October 2018

This article deals with the educator teacher and his work in the Salesian schools since the beginning of the school year to 1939. The daily pedagogical work of teachers was associated with in shaping the intellect, character and religiousness live of the students. Many examples taken from the history of the Salesian schools indicate that the Salesian activity brought good educational results during the Partitions, as well as during World War I or the inter-war period. The social context in which the Poles lived indicated the necessity of raising the culture of the Polish society. This activity was carried out by the Salesian priests and Salesian brothers. Co workers were also invited to cooperate. The necessity of education and training allowed for the openings of schools, but also other institutions, the dormitories, educational institutions, oratories or parishes. There were always children and young people as subjects of the work the Salesians. In education, teachers used the „Pedagogical triad”, based on reason, religion, and love-flowing from the preventive system left by St. John Bosco. It was precisely the „triad” that became the syncretism of the values and strategies proposed learners in the educative process.
Teoria i praktyka królewskiego wychowania na przykładzie eksperymentu edukacyjnego wiktoriańskiego księcia Walii
Authors: Misztal Mariusz
Published: October 2018

Theory and practice of royal education exemplified by the Victorian Prince of Wales For Queen Victoria and Prince Albert the proper education of their eldest son, and the future king of England, was of paramount importance. Their most important advisor in this matter was Baron Stockmar, who believed in strict control of every moment in the boy’s life. The article examines available documentary sources dealing with the theory of the prince’s education as presented mainly in Queen Victoria’s, Prince Albert’s and Stockmar’s memoirs, as well as the way this theory was translated into practice by the Prince’s tutors and teachers. The main documentary sources here are the official reports and private diaries of Lady Lyttelton, Henry Birch and Frederick Gibbs. All in all, to the great disappointment of Mariusz Misztal (this makes no sense...)
Instrukcje rodzicielskie Wacława Rzewuskiego dla syna Seweryna oraz córek Teresy i Ludwiki z lat 1754 i 1763/64
Authors: Kucharski Adam
Published: October 2018

Parental instructions of Wacław Rzewuski for his son Seweryn and daughters from the years 1754 and 1763/64 The education of younger generations had long and rich traditions in the old Polish aristocratic Rzewuski family. The domestic and foreign education of sons in particular played a major role in building the power and social position of the family. The main purpose of this article is to present hitherto unknown sources on the history of the education of members of this family. Between 1754 and 1763 (or 1764) four instructions have survived, written by Wacław Rzewuski for his son Seweryn and two daughters: Teresa Karolina and Ludwika Maria Róża. The first instruction for Seweryn Rzewuski comes from the period of his studies in Warsaw (1754), when the young magnate attended the college of Theatines. In this piece of writing, the father gives detailed instructions on the civic education for his son. This instruction contains advice on how to behave properly during social gatherings and religious ceremonies. It also refers to the rules of the moral education of the young boy. The second instruction for Seweryn contains advice on the protection of the family residences in Podhorce and Olesko and was associated with the political situation in which Waclaw Rzewuski and his sons lived in the years from 1763-1764. However, the two instructions for his daughters are a real rarity. Wacław Rzewuski paid great attention to their security and safety and very good presence. One of the instructions was devoted to the conditions and circumstances for short journeys by the daughters to a nearby church or monastery. In particular, it concerns the staff of the daughters’ traveller suite. Another talks about being cautious with fire during their stay in the palace in Podhorce. Both instructions are unique documents of the realities of daily life and domestic trips by young women from the aristocratic sphere, and a father’s expectations with regard to their proper behaviour and maintaining good manners.
Plastyczność i rewolucja. De Tocqueville, Malabou, Lukács
Authors: Sosnowski Maciej Adam
Published: October 2018

Dialektyczna koncepcja rewolucyjności podkreśla jej podwójny charakter. Zarówno w wersji konserwatywnej (de Tocqueville), jak i socjalistycznej (Lukács) rewolucja jest więc świadectwem ciągłości historycznej i zarazem jej gwałtownym zerwaniem. Celem niniejszego eseju jest uchwycenie tego dwuznacznego fenomenu przy wykorzystaniu pojęcia plastyczności Catharine Malabou. Plastyczność, jako współczesna, postdekonstrukcyjna formuła Heglowskiego Aufhebung, jest pasywno-aktywnym formowaniem, niszczeniem formy i jej zachowywaniem. Jej istota pokrywa się więc z istotą myślenia o rewolucji, zarówno de Tocqueville’a, jak i Lukácsa. Taka dwuznaczność rewolucji może być jednak odczytywana jako wyraz pewnej porażki idei rewolucji jako takiej. Jej uwikłanie w przeszłość skazuje ją na bezproduktywny oportunizm, jej wychylenie w przyszłość – na pusty mesjanizm, a poszukiwanie idealnego zapośredniczenia między tymi skrajnościami zdaje się nie mieć końca. Jeśli współczesność jest trapiona przez to fiasko, to triumfuje w niej przynajmniej jeden aspekt idei rewolucji – pewien sposób myślenia o niej, spekulatywność czy też dialektyka jako taka.
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice
Authors: Zhu Yan , Zhan Guanxia , Fenik Polina , Brandes Madison , Bell Patrick , Francois Noelle , Shulman Katherine , Veasey Sigrid
Published: October 2018

Brainstem locus ceruleus neurons (LCn) are among the first neurons across the lifespan to evidence tau pathology, and LCn are implicated in tau propagation throughout the cortices. Yet, events influencing LCn tau are poorly understood. Activated persistently across wakefulness, LCn experience significant metabolic stress in response to chronic short sleep (CSS). Here we explored whether CSS influences LCn tau and the biochemical, neuroanatomical, and/or behavioral progression of tauopathy in male and female P301S mice. CSS in early adult life advanced the temporal progression of neurobehavioral impairments and resulted in a lasting increase in soluble tau oligomers. Intriguingly, CSS resulted in an early increase in AT8 and MC1 tau pathology in the LC. Over time tau pathology, including tangles, was evident in forebrain tau-vulnerable regions. Sustained microglial and astrocytic activation was observed as well. Remarkably, CSS resulted in significant loss of neurons in the two regions examined: the basolateral amygdala and LC. A second, distinct form of chronic sleep disruption, fragmentation of sleep, during early adult life also increased tau deposition and imparted early neurobehavioral impairment. Collectively, the findings demonstrate that early life sleep disruption has important lasting effects on the temporal progression in P301S mice, influencing tau pathology and hastening neurodegeneration, neuroinflammation, and neurobehavioral impairments.

SIGNIFICANCE STATEMENTChronic short sleep (CSS) is pervasive in modern society. Here, we found that early life CSS influences behavioral, biochemical, and neuroanatomic aspects of the temporal progression of tauopathy in a mouse model of the P301S tau mutation. Specifically, CSS hastened the onset of motor impairment and resulted in a greater loss of neurons in both the locus ceruleus and basolateral/lateral amygdala. Importantly, despite a protracted recovery opportunity after CSS, mice evidenced a sustained increase in pathogenic tau oligomers, and increased pathogenic tau in the locus ceruleus and limbic system nuclei. These findings unveil early life sleep habits as an important determinant in the progression of tauopathy.
Regulation of Root Angle and Gravitropism
Authors: Toal Ted W , Ron Mily , Gibson Donald , Kajala Kaisa , Splitt Bessie , Johnson Logan S , Miller Nathan D , Slovak Radka , Gaudinier Allison , Patel Rohan , de Lucas Miguel , Provart Nicholas J , Spalding Edgar P , Busch Wolfgang , Kliebenstein Daniel J , Brady Siobhan M
Published: October 2018

Regulation of plant root angle is critical for obtaining nutrients and water and is an important trait for plant breeding. A plant’s final, long-term root angle is the net result of a complex series of decisions made by a root tip in response to changes in nutrient availability, impediments, the gravity vector and other stimuli. When a root tip is displaced from the gravity vector, the short-term process of gravitropism results in rapid reorientation of the root toward the vertical. Here, we explore both short- and long-term regulation of root growth angle, using natural variation in tomato to identify shared and separate genetic features of the two responses. Mapping of expression quantitative trait loci mapping and leveraging natural variation between and within species including Arabidopsis suggest a role for PURPLE ACID PHOSPHATASE 27 and CELL DIVISION CYCLE 73 in determining root angle.
NARINGINASE: MICROBIAL SOURCES, PRODUCTION AND APPLICATIONS IN FOOD PROCESSING INDUSTRY
Authors: Yadav Mukesh , Sehrawat Nirmala , K. Sharma Anil , Kumar Vikas , Kumar Amit
Published: October 2018

Naringin is a flavonoid naturally present in citrus fruits. It is present in orange, grapefruit, lemon and other fruits of citrus family. Naringin is the major cause of bitterness in citrus fruit juices. This flavonoid may cause interference during the citrus fruit juice processing. Naringinase (E.C.3.2.1.40) is an enzyme which catalyzes the hydrolysis of naringin into prunin and then into naringenin, which is non-bitter and tasteless. Naringinase is produced by many microorganisms but the commercial production of this microbial enzyme is still the area of interest. Naringinase is chiefly produced by various fungal strains and it has been reported for elimination of bitter flavour (due to naringin) in citrus fruit juice. Few bacterial sources have also been reported for naringinase. Besides removal of bitterness, naringainase has potent application in enhancement of aroma in wine making. This review focuses over microbial sources, production and applications of naringinase in food industries.
IN-VITRO ANTIBACTERIAL, PHYTOCHEMICAL, ANTIMYCOBACTERIAL ACTIVITIES AND GC-MS ANALYSES OF Bidens pilosa LEAF EXTRACT
Authors: Ajanaku Christiana , Echeme Johnbull , Mordi Raphael , Bolade Oladotun , Okoye Stella , Jonathan Hassana , Ejilude Oluwaseun
Published: October 2018

The phytochemical constituents, antimicrobial activity, anti-mycobacterial activity and gas chromatography-mass spectrometry (GC-MS) analysis of the West African ecotype of Bidens pilosa was investigated for possible medicinal properties. The antimicrobial activity of the hexane, dichloromethane, ethyl acetate and methanol extracts from the leaf of Bidens pilosa was evaluated using agar dilution method. The qualitative and quantitative phytochemical screening was carried out according to standard procedures. Partitioned fractions of the methanolic extract was subjected to anti-mycobacterial bioassay. Different fractions of the leaf were subjected to GC-MS to ascertain the compounds present. The antimicrobial analysis revealed the methanolic fraction as having the highest number of activity against test organisms such as: Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Rhizopus sp. between 10 – 40 mm. The minimum inhibitory concentration showed the methanolic fraction to be active against Candida albicans and Rhizopus sp. at the concentration of 6.25 g/ml and 3.25 g/ml respectively. The phytochemical screening revealed the presence of alkaloids, cardiac glycosides and terpenoids in all the solvents. Tannin was present in all the solvent fractions except hexane fraction. Saponin was not found in any of the solvents. The hexane-methanol interface of the partitioned solvents was sensitive to the anti-mycobacterial activity while other solvents showed resistance. The GC-MS and the chromatogram gave insight into the volatile components of the leaf extract. The findings reveals Bidens pilosa as a medicinal plant with potentials for the treatment of tuberculosis.
Schwartz rounds in undergraduate medical education facilitates active reflection and individual identification of learning need
Authors: Stocker Claire , Cooney Andrew , Thomas Peter , Kumaravel Bharathy , Langlands Kenneth , Hearn Jasmine
Published: October 2018

This article was migrated. The article was marked as recommended. Strategies applying Schwartz Rounds to improve wellbeing of medical students has focused on the clinical years of study. This pilot study investigates whether Schwartz Rounds could be effective in developing students' reflective practice in Year 2 undergraduates. Engagement with the Schwartz Round was high with over 50% of the students identifying learning needs through reflection on the Round. Schwartz Rounds promoted recognition of the value of reflective practice and increased self-awareness of student needs.
Carolyn B. Kenny – Reflections on a Humanitarian, A Scholar, A Master Teacher, an Elder – and a Friend.
Authors: Woodward Alpha
Published: October 2018

mm
Repair of soft tissue defects of the fingers with medial plantar venous flap
Authors: Yang Jin , Tang Yongfeng , He Huabin , Fu Shangjun
Published: October 2018

SUMMARY OBJECTIVE To report the surgical procedures and efficacy of using medial plantar venous flap for the repair of soft tissue defects of the fingers. Methods From March 2010 to April 2012, medial plantar venous flaps were harvested to repair the wounds of 31 fingers in 29 cases. Among them, there were 13 middle fingers with defects at the tips in 11 cases, 7 fingers with defects in the dorsal part in 7 cases, and 11 fingers with defects in the finger pulp in 11 cases. The size of the defects ranged from 1.2cm×1.5 cm to 2.5cm × 3.5cm. Medial plantar venous flaps of 1.5cm × 2cm – 3×4 cm were harvested. Full-thickness skin grafts were adopted for the donor areas. RESULTS All 31 flaps survived, except for 1 flap with arterial crisis and 2 cases with venous crisis. These conditions were timely corrected by secondary anastomosis of artery and vein and the flaps survived. The wounds and the donor areas achieved healing by the first intention. All grafted skins survived. Postoperative follow-up was conducted for 26 fingers in 24 cases for 4-12 months, excluding 5 cases with lost follow-up. The dorsal part of the damaged fingers had normal morphology, and the skin color and texture were similar to those of the normal skin. After the repair of defects in the fingertip and pulp, fingerprints appeared, and the protective sensation was restored. CONCLUSION The soft tissue defects of the fingers can be satisfactorily repaired with medial plantar venous flap, and little damage is caused to the donor area. This method is proven effective for the repair of soft tissue defects of the fingers.
Percutaneous endoscopic debridement and irrigation for thoracic infections
Authors: Xu Zhongyang , Zheng Yanping
Published: October 2018

SUMMARY OBJECTIVE: To investigate the safety and efficacy of percutaneous endoscopic debridement and irrigation for thoracic infections and to make an appropriate choice according to the patient's condition. METHODS. Thirty patients with thoracic infections who received surgical treatment from August 2014 to December2016 were retrospectively analyzed. There were 16 males and 14 females, aged from 41 to 90 years, with an average of 64.4 years. A total of 9 cases were treated with percutaneous endoscopic debridement and irrigation (minimal group), and 21 cases were treated with open debridement in combination with pedicle screw fixation (conventional group). Patients underwent follow-up for 1 month. General condition, operative index, laboratory results, and imaging features were recorded. RESULTS. Compared with the conventional group, there were more comorbidities in patients in the minimal group (8 cases in the minimal group, 10 cases in the conventional group, P=0.049), shorter hospital stay (10.1 + 2.26 days in the minimal group, 16.1 + 6.81 days in the conventional group, P=0.016), less bleeding volume (383.3 + 229.86ml in the minimal group, 90 + 11.18ml in the conventional group, P=0.000), lower VAS score at discharge (2.9 + 0.93 in the minimal group, 3.9 + 0.91 in the conventional group, P=0.013). There was no spinal instability case in the minimal group, 10 cases in the conventional group, P=0.013. There were significant differences. The C reaction protein prior to operation in the minimal group was 28.4±7.50mg/L. Compared with 45.1 + 15.78mg/L in the conventional group, P=0.005, it was lower. CONCLUSIONS. Percutaneous endoscopic debridement and irrigation are an effective surgery for treatment of thoracic infections, especially suitable for patients with comorbidities and poor general condition. However, for severe infection and spinal instability, we tend to choose open surgery in combination with fixation.
Ki-67 expression in mature B-cell neoplasms: a flow cytometry study
Authors: Marcondes Natália , Fernandes Flavo , Faulhaber Gustavo
Published: October 2018

SUMMARY OBJECTIVE: Ki-67 is a nuclear protein associated with cellular proliferation in normal or leukemic conditions that can help identify more aggressive diseases and is usually evaluated with immunohistochemistry. The aim of this was to assess Ki-67 expression on mature B-cell neoplasms samples with flow cytometry immunophenotyping. METHOD: After surface staining with CD19 and CD45, intracellular staining for Ki-67 was performed in leukemic mature B-cells. Ki-67 expression was evaluated with flow cytometry. RESULTS: Ki-67 expression was higher in mantle cell lymphoma, Burkitt lymphoma, and diffuse large B-cell lymphoma cases. It was also associated with CD38 mean fluorescence intensity. CONCLUSIONS: Ki-67 expression evaluated by flow cytometry can be a useful tool in the diagnosis of mature B-cell neoplasms. More studies are needed to validate Ki-67 assessment with flow cytometry immunophenotyping.