bluuebunny/crossref_metadata_2025 huggingface dataset:
A study of pharmacognostic profile and antifungal activity of ethanolic extract of kapok banana weevil (Musa balbisiana)
Authors: Warsinah Warsinah  , Hanif Nasiatul Baroroh  , Heny Ekowati
Published: August 2023

Dandruff is an anomaly on the scalp caused by Pityrosporum ovale. Dandruff-treated Ketoconazole shampoo, Excessive caused dermatitis and hair damage. The problem was solved using the kapok banana weevil as an alternative treatment. This study aims to determine the quality of kapok banana weevil simplicia and its anti-functional activity against P. ovale. The study was conducted in two stages, the first of which involved Pharmacognostic profiles on macroscopy, microscopy, Simplicia quality, and phytochemical screening. Examining the inhibitory zones of the ethanolic extract of P. ovale at doses of 0.5%, 1%, 2%, 4%, 5%, 10%, 20%, and 40% reveals stage 2 antifungal activity. Employing the Kirby-Bauer diffusion as a positive control with ketoconazole and a negative control with sterile aqua dest. A 95% confidence level LSD post hoc test, one-way ANOVA, and description technique were used to evaluate the data. Results: The Kapuk banana weevil's Simplisia met high standards for Simplisia quality, and its ethanol extract was able to stop P. ovale growth by creating an inhibition zone. The ethanol extract of the Kapuk banana weevil was able to suppress the development of P. ovale with an inhibition zone extending from 0.5 to 17.16 mm and positive control (ketoconazole) of 23.5 mm. The Simplisia of the Kapuk banana weevil had good simplicia quality standards. Extract with concentration of 40%and a 17.16 mm inhibition zone, the activity was at its peak. The pharmacognostic profile demonstrates the high quality of Simplicia, and the activities of the kapok banana weevil extract are at their peak at a concentration of 40% at a diameter of 17.16 mm.
A 19. század daliás szent királya: Szent László emlékezete a Vasárnapi Ujság oldalain
Authors: Fabó Edit
Published: August 2023

Szent László a magyar történelem egyik legközismertebb uralkodója. A tanulmány a lovagkirály emlékezetének recepciótörténeti folyamatát kíséri végig a Vasárnapi Ujság oldalain a XIX. század második felében. Az elemzés arra a kérdésre összpontosít, hogy miként jelenítették meg a nagy királyt abban a korban, amikor a modern társadalom világképe is formálódott. A hetilap egyébként is igyekezte megtámogatni az általában függetlenségpárti közvélemény életérzését, amelyben a történelmi tudat, a hősi idők emléke ápolta a hazaszeretetet, a hazafiságot. A szerkesztőség több szálon idézte fel Szent Lászlót olvasói számára: ízelítőt adott a róla kialakult hagyományból; népszerűsítette a történeti műveken alapuló irodalmi feldolgozásokat, amelyek átélhetőbbé tették az egykori király életét, cselekedeteit és küzdelmeit; bemutatta a művészeti alkotásokat, amelyek még inkább az idealizált eszmény felé terelték a képzeletet; a tudomány eredményeinek ismertetésével pedig a történeti emlékezet valóságalapját erősítette és felhívta a figyelmet külhoni emlékekre. A folyóirat hűen közvetítette a nagy király emlékezetének alakulását, megjelenítésének módját.
КАМЕЛИН И СОВРЕМЕННЫЕ ПЕРСПЕКТИВЫ // CAMELYN AND MODERN PERSPECTIVES
Authors: Bakradze Inga , Kiknadze Vasili , Chikhladze Maia , Lomineishvili Levan
Published: August 2023

Камелин – созданный в Грузии препарат, авторство которого связано с именем Бенедикте Маглагелидзе в прошлом веке. За прошедшие годы Камелин добился успеха как на местном, так и на международном уровне, будучи признанным высокоэффективным препаратом для борьбы со многими заболеваниями. Цель исследования состоит в том, чтобы оценить потенциальное действие медового экстракта Камелина как современного лекарственного средства при заболеваниях желудочно-кишечного тракта (Вандерер 1946; Ф. Меньшиков, С. Фельдман, П. Медовиков, А. Гельтман 1949), нервной системы и анемических заболеваниях (Цельский, 1946), в практике детских болезней (Фрауслендер, Эмрих 1946, Голумб и др.). Н. Йориш (Н. Йориш 1946) успешно применяет мед против абсцессов легких. Он безопасен, не имеет цитотоксического эффекта, а также продемонстрировал противовирусные свойства против SARS–CoV–2. Учитывая текущую чрезвычайную ситуацию, вызванную пандемией COVID–19, и ограниченные терапевтические возможности, Камелин представлен как многообещающий и актуальный терапевтический вариант, который безопасен, прост в применении перорально и легко доступен в качестве натуральной добавки. // Camelyn is a drug created in Georgia, the authorship of which is associated with the name of Benedikte Maglagelidze in the last century. Over the years, Camelyn has achieved both local and international success being recognized as a highly effective drug for fighting many diseases. The aim of the study is to evaluate the potential effects of honey extract Camelyn as modern medicine against gastrointestinal (Vanderer 1946; F. Menshikov, S. Feldman, P. Medovikov, A. Geltman 1949), nervous system and anemic diseases (Tselskij 1946), in the practice of children’s diseases (Frauslender & Emrich (1946), Golumb et al). N. Yorish (N. Yorish 1946) applies honey successfully against lung abscesses. It is safe, with no cytotoxic effect and has also demonstrated antiviral properties against SARS–CoV–2. Research of published information and Internet resources on the topic of the article.
ИЗУЧЕНИЕ АНТИОКСИДАНТНОЙ АКТИВНОСТИ ДИАМИДОВ ЩАВЕЛЕВОЙ КИСЛОТЫ В ОПЫТАХ IN VIVO, IN VITRO, IN SILIKO // STUDY OF ANTIOXIDANT ACTIVITY OF OXALIC ACID DIAMIDES IN EXPERIMENTS IN VIVO, IN VITRO, IN SILIKO
Authors: Pahutyan Nvard , Hunanyan Hovhannes , Navoyan Qristine , Bagdasaryan Srpui , Aghekyan Asya , Gasparyan Hrachik
Published: August 2023

Исследовалась роль производных ряда диамидов щавелевой кислоты на процесс течения реакции свободнорадикального окисления липидов в гомогенатах мозга и печени белых крыс. Выявлено, что изученные соединения в концентрации 0,3мг/кг проявляют свою антиоксидантную активность (АОА) главным образом в печеночной ткани, и более низкие показатели – в мозгу белых крыс. На основании проведенных исследований можно сделать заключения об антиоксидантной активности соединений ряда диамидов щавелевой кислоты на процесс свободнорадикального окисления липидов в мозгу и печени. Выявлено заметное подавление процесса перекисеобразования липидов (ПОЛ). Также были рассчитаны потенциальные фармакологические свойства исследуемых соединений и установлено, что исследуемые соединения соответствуют «Правилу пяти» Липинского. // The role of derivatives of a series of oxalic acid diamides on the course of the reaction of free radical oxidation of lipids was studied in homogenates of the brain and liver in albino rats. It was found that the studied compounds at a concentration of 0.3 mg exhibit their antioxidant activity (AOA) mainly in the liver tissue and lower levels in the brain of white rats. On the basis of the studies carried out, it can be concluded that oxalic acid diamides have an antioxidant activity on the process of free radical lipid oxidation in the brain and liver. It was found that they significantly suppress the process of lipid peroxidation (LPO). Drug likeliness in-Silko predictions were also performed and as of result all compounds were in accordance with Lipinski 5-rule.
ОБЗОР ОСНОВНЫХ СВОЙСТВ ОРИГИНАЛЬНОГО БЕТА-АДРЕНОБЛОКАТОРА ФОБУФОЛА // MAIN PROPERTIES OF THE BETA-ADRENOBLOCKER FOBUFOL REVIEW
Authors: Shirinyan Marine , Tsatinyan Anik , Noravyan Hovsep , Markaryan Eduard
Published: August 2023

В статье дан обзор основных фармакологических свойств синтезированного в Институте тонкой органической химии им. А.Л. Мнджояна Научно-технологического центра органической и фармацевтической химии НАН РА неселективного β-адреноблокатора (БАБ) фобуфола. Приведены результаты сравнительного исследования фобуфола и пропранолола относительно их действия на сердечно-сосудистую систему, вегетативную нервную систему, на гликогенолиз в покое и при стрессе, а также их влияния на функцию артериального барорефлекса. // The article provides review of the main pharmacological properties of Fobufol developed at the A.L. Mnjoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry NAS RA. The results of a comparative study of Fobufol and Propranolol regarding their effect on the cardiovascular system, autonomic nervous system, glycogenolysis at rest and under stress, as well as their effect on the arterial baroreflex function are presented.
НЕЙРОПСИХОЛОГИЧЕСКИЙ ПОДХОД СОЦИАЛИЗАЦИИ ЛИЦ ВО ВРЕМЯ И ПОСЛЕ ТЮРЕМНОГО ЗАКЛЮЧЕНИЯ // NEUROPSYCHOLOGICAL APPROACH TO SOCIALIZATION OF PERSONS AFTER AND DURING PRISON
Authors: Sargsyan Vahram , Harutunyan Anahit , Hovsepyan Maia , Manukyan Liana
Published: August 2023

В научной работе, на основе новых генетических и вирусных теорий предлагается эффективный и обоснованный подход для реабилитации и социализации лиц после и во время тюремного заключения. Данная тема очень важна для понимания механизмов создания более стабильного человеческого общества, укрепления государственности и защиты прав человека. Решение проблемы социализации человека реализуется благодаря новому двухэтапному методу реабилитации: нейробиологическому и психосоциальному. // In scientific work, based on new genetic and viral theories, an effective and reasonable approach is proposed for the rehabilitation and socialization of persons after and during imprisonment. This topic is very important for understanding the mechanisms for creating a more stable human society, strengthening statehood and protecting human rights. The solution to the problem of human socialization is realized thanks to a new two-stage method of rehabilitation: neurobiological and psychosocial.
УСЛОВИЯ, ФАКТОРЫ И ПРАВИЛА УСПЕШНОСТИ КОМАНДЫ ВРАЧА ОБЩЕЙ ПРАКТИКИ В ОБЕСПЕЧЕНИИ КАЧЕСТВА МЕДИЦИНСКОЙ ПОМОЩИ // CONDITIONS, FACTORS AND RULES FOR THE SUCCESS OF THE GENERAL PRACTITIONER TEAM IN ENSURING THE QUALITY OF MEDICAL CARE
Authors: Matveychik Tatyana
Published: August 2023

Команда врача общей практики (ВОП) становится связующим звеном участия общества в обеспечении качества медицинской помощи, чему будут способствовать организационно-психологические методики в их труде. Кредо, отражающее основные ценности организации здравоохранения и всех задействованных сторон, усиливает сплоченность и порождает согласованность действий участников, а культура в команде ВОП – это то, что долго достигается, но высоко ценится. Сотрудничество медицинских работников носит комплексный характер и основывается на современных достижениях медицинской науки с использованием методологии системного подхода, принципах доказательной медицины и знании эффективной коммуникации. // The team of general practitioners (GPs) becomes a link between the participation of society in ensuring the quality of medical care, which will be facilitated by organizational and psychological methods in their work. A credo that reflects the core values of the healthcare organization and all parties involved, strengthens cohesion and generates consistency of actions of participants, and the culture in the GP team is something that takes a long time to achieve but is highly appreciated. The cooperation of medical workers is complex and based on modern achievements of medical science using the methodology of a systematic approach, the principles of evidence-based medicine and the knowledge of effective communication.
ПОИСК АКТИВНЫХ СОЕДИНЕНИЙ ИЗ РЯДА НОВЫХ ПРОИЗВОДНЫХ 1,4-БЕНЗОДИОКСАНА, ОБЛАДАЮЩИХ АНТИГИПОКСИЧЕСКОЙ АКТИВНОСТЬЮ // SEARCH FOR ACTIVE COMPOUNDS FROM A NUMBER OF NEW DERIVATIVES OF 1,4-BENZODIOXANE WITH ANTIHYPOXIC ACTIVITY
Authors: Harutynyan Seda , Tsatinyan Anik , Vardanyan Svetlana , Grigoryan Marine , Pogosyan Anahit , Gasparyan Hrachik
Published: August 2023

Изучена антигипоксическая активность ацилзамещенных гидразидов 1,4-бензодиоксан-2-карбоновой кислоты и 2,5-дизамещенных 1,3,4-оксадиазолилбензодиоксанов. Были выделены и исследованы 3 производных в моделях гипоксической, гемической и циркуляторной гипоксии. // The antihypoxic activity of acyl-substituted hydrazides of 1,4-benzodioxane-2-carboxylic acid and 2,5-disubstituted 1,3,4-oxadiazolylbenzodioxanes was studied. Three derivatives were isolated and studied in models of hypoxic-hypoxia, hemic hypoxia and circulatory hypoxia.
Assessment of Knowledge and Beliefs toward Osteoporosis among Iraqi Perimenopausal Women
Authors: Alfadhul Shaymaa Abdullateef , Abbas Zahraa Hamad
Published: August 2023

Background: Osteoporosis is becoming more common, especially among women. Prevention through educational initiatives is the best way to lower the disease burden. Objective: To estimate perimenopausal women's knowledge and attitudes concerning osteoporosis and their relation to specific sociodemographic characteristics. Methods: 391 perimenopausal women who were utilizing the outpatient clinic facilities at the hospitals in Al-Najaf City participated in a cross-sectional study. Starting in May 2022, data was gathered for six months. Data were gathered using a questionnaire that asked about sociodemographic factors, the Osteoporosis Knowledge Assessment Tool, and the Osteoporosis Health Belief Scale. Results: In this study, a substantial proportion of the participants have poor knowledge (61.89%), while average and good knowledge encompass 31.97% and 6.10% of the participants, respectively. The mean score for osteoporosis knowledge was 7.18±3.49. About osteoporosis health beliefs, the best belief of women is in perceiving the benefits of calcium intake; the mean score was 20.32±4.69. A significant positive correlation (p<0.001) was found between knowledge and exercise benefits, calcium intake benefits, perceived severity, and health motivation, whereas a significant negative correlation (p<0.001) was found between knowledge and barriers to calcium intake and exercise. Conclusion: The participants have below-average knowledge and beliefs regarding osteoporosis. Knowledge of osteoporosis correlates positively with health beliefs, including perceived susceptibility, health motivation, the benefit of calcium intake, and the benefit of exercise, whereas it correlates negatively with barriers to calcium and barriers to exercise.
Diabetic ketoacidosis induced Takotsubo cardiomyopathy: A case report
Authors: Teeratakulpisarn Napassorn , Tongyoo Surat , Purngcharoenkul Saranthorn
Published: August 2023

Takotsubo cardiomyopathy (TC) is a syndrome of transient regional wall motion abnormalities of the left ventricle causing an apical ballooning pattern. This condition can be triggered by intense emotional or physical stress. In the past, many case reports showed cases of diabetic ketoacidosis induced Takotsubo cardiomyopathy who presented with initial ST segment elevation ECG at the present to the hospital simultaneously with the ongoing stress. In this paper, we report a case of Takotsubo cardiomyopathy whose ST segment changed 2 days after the resolution of diabetic ketoacidosis.
Factors Affecting the Likelihood of Fraudulent in Procurement Process: the Case of Royal Malaysian Air Force
Authors: Azhar Ramli Mohd , Aziz Nazirah
Published: August 2023

Procurement encompasses activities and processes of purchasing good products and services in the public or private sector. It has been reported that 60% of fraud and economic crime perpetrators in the public sector were from government officials. Procurement fraud has increased in the public sector since 2012. This study aims to investigate the practice and likelihood of fraud in the Royal Malaysian Air Force (RMAF) procurement process and to recommend the course to improve the effectiveness of implementing the e-procurement system. This study employed a quantitative method to achieve the objectives of the research. This study adopted a questionnaire from previous research instruments used in many studies related to fraud intention as the primary data collection method. The questionnaire was distributed to the selected officers and other ranks within RMAF. The respondents were among all officers and employees involved directly in the procurement process. Using quantitative research for the data collection method allowed the researcher to evaluate and understand this data through statistical analysis. This study's findings revealed that work commitment, capability, and opportunity had a significant association with the likelihood of fraud in the RMAF e-procurement system when Pearson's correlation was used. Results from regression analysis addressed that capability and opportunity significantly influence the possibility of fraud.
Contextualization and the Old Testament: Between Asian and Western Perspectives
Authors: Yee Chin Hong
Published: August 2023

This is a book review of Jerry Hwang, Contextualization and the Old Testament: Between Asian and Western Perspectives (Carlisle, UK: Langham Global Library, 2022), xxi + 238 pp., ISBN: 978-1-83973-413-7, $29, paperback.
Whom Does God Love?
Authors: Dodds Adam
Published: August 2023

The hadith control the daily lives of Muslims. For Christians seeking to engage with Muslims, understanding the hadith is indispensable. This article investigates, “Whom does God love according to the Bible and the hadith?” Comparative studies exist for the Bible and the Qur’an but less for the hadith. This study scrutinizes what the Bible and hadith, respectively, mean by divine love. First, I describe divine love in the Bible and, second, in the main Sunni hadith collections. I study Allah’s love for himself, for named individuals, and requests for Allah’s love, and next, I investigate earning Allah’s love, deeds that earn Allah’s love, and Allah’s love for certain character qualities. Lastly, I examine the implications of divine love by addressing the following questions: How does the conception of divine love determine human love? What are the implications of this study for engagement with Muslims?
The Church as an Alternative Polis
Authors: Zhao Wenjuan
Published: August 2023

This article explores three different views of Wang Mingdao’s ecclesial stance and his approach to the Three-Self Patriotic Movement (TSPM): his refusal to join the TSPM as a political rather than theological approach to resisting the Chinese Communist Party; his refusal to accept the TSPM’s authority as the Protestant church’s resistance to Chinese hegemony; and his ecclesial stance as a sectarian withdrawal from the world. Considering these diverse scholarly perspectives, I interpret Wang’s response to the TSPM as part of a necessary proclamatory action and propose that Wang’s model of radical action models the politics of Jesus. His church is political only as defined by the gospel, and it represents a new polis—a kind of community established in and through Jesus of Nazareth to stand as a political alternative to the dominant politics of the world and contribute to an alternative identity of a citizen. I, therefore, approach Wang’s faith practice from an ecclesiological standpoint and situate him and his ecclesial activities into the historical and theological context to explore his biblical-theological foundation for this new polis and its public witness. I argue that Wang’s rejection of the TSPM and his alternative way of engaging with political issues such as imperialism, nationalism, and church-state relations show that his ecclesial stance is novel and distinct from other forms of politics.
William T. Cavanaugh’s Eucharistic “Reimagination” of Space and Time
Authors: Tan Gabriel
Published: August 2023

Asian churches, indebted to fervent and faithful missionaries, have long understood that the church is called to challenge the culture around us, including the world’s concept of the sacred-secular divide. Still, we, as part of the Protestant Church, have unknowingly adopted this worldly imagination in subtle ways, especially with regard to the church’s understanding of space and time. Using the works of William Cavanaugh, this article seeks an understanding of space and time that primarily grounds itself in the Eucharist and, therefore, in the church’s identity as the Body of Christ, radically different from how the world defines it. It then explores some practical implications in discipleship and missions.
DESIGN OF AUTOMATIC WATER FAUCET FOR A READY FOOD RESTAURANT SINK USING MICROCONTROLLER BASED ULTRASONIC SENSOR
Authors: Asri  , Akmal Sujudi  , Andik Bintoro  , Habib Muharry Yusdartono  , Ezwarsyah
Published: August 2023

Technological developments in the field of control are increasingly advanced, especially in the world of electronics. Electronic water faucets are one example that we can find in fast food restaurants which are quite expensive for some groups and water is often wasted when the hand washing process is in progress. Therefore this research was carried out by designing and building an automatic faucet in a sink so that there is no wastage of water. The problems faced are the use of manual faucets that are not sterile and the process in the field when washing hands is not efficient and hygienic. The method used is to design and build mechanical and electronic components based on microcontrollers. By utilizing Arduino UNO, HC-SR04, L298N, Relay and DC pump, hand washing sink will facilitate the hand washing process. The design of an automatic water faucet for a fast food restaurant sink based on a microcontroller was successfully realized and implemented with the realization that water managed to come out of a 12V DC pump capable of dispensing water according to the reach of the hand between 2.5cm to 27.5cm which was carried out by the HC-SR04 sensor. The process carried out is that the automatic water faucet at the sink in a fast food restaurant can simplify the hand washing process and reduce water wastage with a water saving of 5.3 liters for adults and 8.66 liters for small children. The average water used by adults for automatic sinks is 0.49 Ɩiter/person and young children is 0.45 Ɩiter/person, with a water velocity of 0.163 Ɩ /s for adults and 0.150 Ɩ /s for small children.
Mystery of Panchmahabhuta in the Ayurvedic Treatment of Human Soul
Authors: Khwaja Ayub
Published: August 2023

ABSTRACT
According to Ayurveda, human being is a microcosm (miniature of the universe). It is evident then, whatever is present in the universe should also be present in the human composition. As Earth is composed of 71% of water and about same percentage of water is also found in the physique of babies, indicating that the human creation is truly a mixture of clay and water. Panchmahabhuta is one of the fundamental principles of Ayurvedic science having resemblance with the components of the earth. Panch = five; Maha = larger and Bhuta = elements, thus Ayurveda believes in five major elements in human beings like five major elements of the Earth such as atmosphere, hydrosphere, lithosphere, mantle and core. It is noticeable that Akash (sky) and Vayu (air) are components of atmosphere; Jala (water) corresponds to hydrosphere; Pruthvi (Earth) relates with lithosphere and Agni (fire) resembles mantle and core. Out of 118 elements discovered so far, about 22% is identified in human beings (Panchbhuta of the body), which governs the physical, chemical and biological processes of the body. These elements are responsible for maintaining tridosha called as Vata, Pitta and Kapha. Malfunctioning in any of these tridosha creates an imbalance in the human system leading to ailment and diseases. This paper endeavors to understand this Mystery of human creation and its coherence with Ayurvedic treatments and its ability to fight disease by interacting with corresponding natural elements of the universe.
Memory Enhancing Activity of Unripe Fruits of Elaeocarpus ganitrus (Rudraksha) in Albino Wistar Rats
Authors: Kaur Tavleen , Rana Dr , Parashar Twinkle
Published: August 2023

Learning, the process of acquiring memory such as changing behavior due to previous experiences which is mostly studied subjects in neuroscience. Elaeocarpus ganitrus (EG) is traditionally used to treat psychoneurosis and other neuronal disorders in humans. In this EG extract doses (100, 150, and 200 mg/kg) (p.o.) were used. Learning and memory activity of EG extract was assessed in albino wistar rats using the elevated plus maze, acetylcholinesterase enzyme level in whole brain tissue homogenate and was determined using one-way ANOVA by Dunnett's test. Rats pre-treated with EG extract and piracetam showed significant reduction in TL in elevated plus maze test. In addition, level of acetylcholinesterase enzyme was also decreased compared to the negative control group in dose-dependent manner which showed increase in learning and memory. The data showed that ethanolic extract of unripe fruits of Elaeocarpus ganitrus has significant effect on improving memory in the treated animals.
Randomized Controlled clinical trial of Rasaraj Rasa and Vajigandhadi Basti in the management of Post-Stroke Depression (PSD)
Authors: Jain Dr , Murthy Prof , Singh Dr , Tripathi Prof , Tripathi Prof
Published: August 2023

Abstract:

Aim: Comparative clinical evaluation of, Sertraline, Rasaraj rasa and combination therapy of Rasaraj rasa with Vajigandhadi Basti in the management of PSD.

Material and Methods: A total number of 78 patients presenting with features of Post-Stroke depression and fulfilling the DSM-IV diagnostic criteria were registered from the OPD/IPD of the concerned hospital. They were randomly allocated on three groups. Group A was considered as control and was treated with tablet Sertraline Group B was treated with tablet Rasaraj rasa while Group C was treated with Vajigandhadi tail Basti therapy along with Rasaraja Rasa 125 mg. Total three follow up were taken at one month interval each. During the study period 18 patients were dropped out and 60 subjects completed the entire study. The assessment was done through Hamilton Depression rating scale and Barthel scale.

Results: The therapeutic effect of Rasaraj Rasa along with Vajigandhadi basti therapy was found better as compared to other groups.

Conclusion: Study has shown significant changes over symptoms of PSD i.e. both on level of depression and motor functioning. This study has opened new vista for further study in the field of Neuro-psychiatric disorders using Ayurvedic principles of management with special reference to PSD.
Effect of ASA-20 (Ayush Kwath, Samsamani Vati, Anu Taila) as a prophylactic measure for COVID-19 in High-Risk population – A prospective interventional study
Authors: Goswami Pradip , Lekharu Sikha , Parveen Rehana , Bhattacharjee Abhishek , Baruah Himangshu , Choudhury Bishnu
Published: August 2023

Background: The SARS Cov-2, has emerged as one of the biggest global health threats of the 21st century. It symptomatically varies from having mild to severe symptoms with fever, cough, breathing difficulty, anosmia, diarrhea etc. With the frequent changing protocols and no drug of choice till date, the management of COVID-19 can be structured through some preventive measures/medicines.
Aims and Objectives: To assess the efficacy of ASA-20 (Ayush kwath, Samsamani vati, Anu taila) in preventing COVID-19 infection in healthy volunteers as a prophylactic measure among high-risk populations (Health Care Workers/Containment Zone & Quarantined Population) exposed to COVID-19.
Materials and Methods: A total of 5000 subjects aged between 18 to 68 years were enrolled in to the study and non randomly divided into two groups. Subjects in Group-A (trial group) were given ASA-20 orally for 30 days along with standard preventive care as recommended by ICMR while subjects enrolled in Group-B (control group) were advised to follow only standard preventive care. Assessment was made based on Immune status questionnaire, general health questionnaire and COVID-19 positivity status during the study period. Follow ups were done on day 1, 15, 30 and 45. Statistical analysis was done by using Chi-square test and Fisher test.
Results: 0.80% and 1.79% subjects were found to have tested positive in the trial and control group respectively. The results show that control group is 2.26 times more likely to contract COVID-19 than the trial group. In other words, the medicine is effective in reducing the contraction of COVID-19 by more than half.
Detection Of Panton–Valentine Leukocidin Gene In Methicillin Resistance Staphylococcus Aureus: Clinical And Epidemiological Aspects
Authors: mohan Sneha , mohan Sneha , Sarwat Tarana , singh satendra , Kakru Dalip
Published: August 2023

Introduction: The role of PVL in the disease process and severity of S.aureus till now is a debate matter. The data provide substantial evidence that the high virulence potential of CA-MRSA isolates is associated with the expression of PVL. PVL genes carried by HA-MRSA strains have also been recently described in cutaneous and invasive infections. Epidemiology of MRSA strains is constantly changing and is known to vary between hospitals. This study aimed to analyze the prevalence of PVL in MRSA isolates from patients using multiplex PCR. Material and Methods: Staphylococcus aureus were isolated from various clinical samples received in Bacteriology Laboratory using standard protocol. Antibiotic susceptibility testing was performed by Kirby – Bauer disc diffusion method. Detection of PVL genes by multiplex PCR.Results: The highest prevalence of MRSA PVL positive isolates was from pus sample (74.5%) followed by blood (16.3%). The results of antimicrobial susceptibility testing revealed almost similar pattern of antibiotics resistance among PVL negative MRSA isolates as compared to PVL positive MRSA isolates. Conclusion: The detection of PVL-producing MRSA will help us in framing and planning the infection control measures against the MRSA infections.
Does the sonography-scintigraphy correlation affect the success of minimally invasive parathyroid Surgery? Results from a single center
Authors: Ozdemir Ali , Kalca Suleyman
Published: August 2023

In patients with primary hyperparathyroidism, complete surgical resection of all hyperfunctioning parathyroid tissue is essential. The aim of this study was to evaluate the success rates of minimally invasive parathyroidectomies for primary hyperparathyroidism performed after localization studies with 99mTc-sestamibi (MIBI) scintigraphy and neck ultrasonography (USG). And also, we aimed to determine the factors affecting the success rate in surgery. Retrospective analysis of 58 consecutive patients with a diagnosis of primary hyperparathyroidism who underwent parathyroidectomy between January 2018 and December 2021 in our institution. The patients were evaluated according to Miami criteria and divided into two groups as successful or unsuccessful surgery. Demographic and clinical characteristics of the patients were obtained from hospital records. Surgical success was achieved in 50 (86.2%) of the 58 patients included in the study. In both groups, neck USG and MIBI scintigraphy showed the same localization for the lesion in a correlated manner. The clinical complaints of the patients, preoperative PTH, Ca and 24-hour urinary Ca levels were similar in both groups. In 10 (17.2%) patients, inconsistency in localization was found between USG and MIBI scintigraphy, and surgical failure was found in 4 (40%) of these patients. Surgical failure was statistically significant in patients with inconsistency in localization between USG and MIBI scintigraphy. The sono-scintigraphic scan concordance increases surgical success rates in cases where minimally invasive parathyroid surgery is planned. If there is an inconsistency between USG and MIBI, preoperative four dimentional computed tomography, intraoperative rapid PTH, gamma probe or frozen method can be used. It should be kept in mind that multiple gland pathologies may be more common in addition to solitary adenoma in lesions smaller than 1 cm in USG. In addition, in these cases, as the diagnostic value of scintigraphy is low, surgical success will also decrease.
A prospective observational study on the effectiveness of pterygium excision with limbal conjunctival autograft transplantation and recurrence in patients of primary pterygium
Authors: Dhali Dibyendu , Barua Nabanita , Thakur Sanjay , Das Debabrata
Published: August 2023

Background: Pterygium is a degenerative and hyperplastic process with abnormal fibrovascular proliferation. Surgery is the treatment of choice in progressive or symptomatic cases but recurrence is a concern.

Aims and Objective: We aim to evaluate the effectiveness of pterygium excision and conjunctival autograft (done by post-graduate trainees in the 2nd and 3rd year of residency under supervision) and recurrence of this process in a tertiary care setup.

Materials and Methods: It is a single-centric prospective observational study. 50 patients who underwent pterygium excision with conjunctival autografting surgery in a tertiary care hospital were followed up for 1 year. Patients were evaluated on day 1, day 7, 1 month, 6 months, and 1 year. Efficacy and graft stability were assessed on day 7 and 1 month; 6 months and 1 year for recurrence and the factors associated with it.

Results: Total number of patients was 50; 31 were female, and 19 were male. All cases were effectively managed with excision and autograft. Post-operatively, 13 (26%) patients had shown suture loosening, 17 (34%) patients had graft edema, and 13 (26%) patients had post-operative recurrence. Out of 13 patients, 8 patients had mild recurrence, 4 patients had moderate recurrence, and 1 patient had severe recurrence. Graft stability is significantly associated with suture loosening (P < 0.05). There is no association between the extent and grade of pterygium (P > 0.05). Recurrence was statistically highly associated with (P < 0.0001) suture loosening.

Conclusion: We conclude that autografting is an effective technique. Intraoperative proper suturing technique and minimal tissue manipulation can minimize recurrence.
Correlation of clinical features, cytological, and histopathological findings of breast lumps
Authors: Shah Jainesh , Galani Kamlesh , Galani Manisha
Published: August 2023

Background: Breast carcinoma is the most common malignant tumor of females worldwide. Variety of breast lesions ranging from inflammatory to benign to malignancy can present as palpable breast lump. Early diagnosis and prompt treatment of this lump can prevent a significant morbidity and mortality associated with the disease. Fine needle aspiration cytology (FNAC) is simple, readily available, rapid, and accurate diagnostic tool for evaluating breast lump.

Aims and Objectives: (i) Correlation of FNAC findings with histopathology (HPE) diagnosis; (ii) To evaluate clinical presentation and demographic profile of patients with breast lump.

Materials and Methods: This study was carried out from June 2021 to July 2022 at C. U. Shah Medical College and Hospital, Surendranagar, in the General Surgery department along with the Pathology department. It was a prospective observational type of study which included 75 patients presented with breast lump. All the patients were evaluated clinically and then investigated by FNAC and either core biopsy or excision biopsy then sample sent to the pathology department. Results of the FNAC were categorized and correlated with HPE findings.

Results: In our study, benign lesions were more common than malignant ones on FNAC. Among benign lesions, fibroadenoma was the most common (36/75 cases) lesion involving the young females (20–29 years), followed by fibrocystic disease (16/75 cases). Malignant lesions-carcinomas were found (6/75 cases) in the age group of 30–39 years. Two out of 75 cases were of phyllodes tumors, followed by other benign lesions in small numbers. Cytological findings were consistent with HPE reports in 72 cases with the sensitivity of 100% and 98.55% specificity.

Conclusion: Findings of FNAC are correlated well with HPE reports which are considered the gold standard method for tissue diagnosis. In addition, FNAC is a simple, rapid, easily available, outpatient department based, and cheap procedure with high sensitivity and specificity. Hence, it can be used as an early diagnostic tool for evaluation of the patient with breast lump and ultimately will guide the clinician to determine the line of treatment.
Prilog poznavanju mikroklime nekih šumskih staništa u području istočne Bosne
Authors: Stefanović Vitomir
Published: August 2023

Pored međusobnih odnosa biljnih vrsta izraženih u prilagođavanju i u borbi za opstanak te faktora prošlosti i razvitka flore i vegetacije određenog područja, stanišni ušlo vi su jedan od glavnih činilaca u izgradnji biljnih zajednica. Čovjek svojim svjesnim djelovanjem mijenja često stanišne uslove, a posljedica toga je da se biljne zajednice mijenjaju u fizionomiji, sastavu i strukturi. Otud je poznavanje osobina staništa šumskih zajednica značajno ne samo u teoretskom nego i u praktičnom šumarskom smislu, jer ukazuje na mogućnost obnove vegetacije svuda gdje je ona uništena ili čovjekovim uticajem nepovoljno izmijenjena. Dosad su mnogi istraživači u inostranstvu posvetili svoje studije izučavanju ekologije staništa: J. Braun-Blanquet i P. Fukarek (1), J.Eggler (3), J. Fabijanowski (4), R.Geiger (5), G.Kraus (10), H.Lundegard  (11), W. Lüdi (12),Pallmann-Frei (14) i drugi. U našoj zemlji poklanja se u novije vrijeme takođe pažnja istraživanju mikroklimatskih odnosa pojedinih šumskih staništa, a u okviru kompleksnih istraživanja fitocenoza: B. Jovanović (9), E. Ilić (8), L. Rajevski (15), V. Stefanović (16) i dr. U ovom radu iznose se rezultati istraživanja nekih osnovnih ekoloških svojstava staništa šumskih zajednica bijelog bora u odnosu na staništa šumske zajednice jele i bukve kao klimatogene šumske zajednice na području istočne Bosne. Cilj istraživanja je bio da se ustanove odnosi pojedinih klimatskih elemenata na jednom užem prostoru u nekoliko najkarakterističnijih šumskih zajednica. Jasno je da istraživanja ove vrste mogu imati samo relativnu vrijednost, jer bi za postizanje apsolutnih vrijednosti u ovom smislu bila potrebna posmatranja u znatno dužem vremenskom periodu. Šira fitocenološka istraživanja na području istočne Bosne izvršena su u razdoblju od 1955. do 1958. godine u sklopu zadataka bivšeg Zavoda za šumarsku botaniku Šumarskog fakulteta u Sarajevu.
Tipovi degradiranih bukovih šuma na karbonatnim supstratima u Bosni i Hercegovini
Authors: Stefanović Vitomir , Drinić Petar , Ćirić Milivoje , Đikić Salko , Burlica Čedomir , Fabijanić Branibor
Published: August 2023

Ovaj rad predstavlja nastavak istraživanja tipova šuma u Bosni i Hercegovini (Ćirić M. i dr., 1971., Fabijanić B. i dr., 1967.) s ciljem da se pruži šumarskoj praksi osnova za racionalnije iskorištavanje različitih šumskih staništa. Rad predstavlja sintezu fitocenoloških, pedoloških, šumskomeliorativnih i taksacionih istraživanja, a po načinu obrade i metodici je istovjetan kao i prethodni rad o klasifikaciji tipova bukovih šuma i mješovitih šuma bukve, jele i smrče u Bosni i Hercegovini (Ćirić M. i dr., 1971.).

Dio rada o vegetaciji obradili su Stefanović V. i Fabijanić B., o zemljištu Ćirić M. i Burlica Č., o taksacionim elementima Drinić P., o šumsko meliorativnim zahvatima Djikić S.

U radu su korišteni podaci iz prikupljenog materijala inventure šuma na velikim površinama u Bosni i Hercegovini (Matić V. i dr. 1971.). U obradu su uvršteni veći kompleksi degradiranih bukovih šuma u Bosni i Hercegovini (oko 27% površine svih degradiranih bukovih šuma u Bosni i Hercegovini) na jedrim mezozojskim krečnjacima, tercijernim krečnjacima, laporcima i glincima.
Rezultati istraživanja utjecaja proreda na prirast drvne mase po količini i kvalitetu u G.J. "Igman" kod Sarajeva
Authors: Pintarić Konrad
Published: August 2023

Njega sastojina spada u one uzgojne mjere, kojima je cilj da do maksimuma iskoristi prirodne mogućnosti staništa, da plodnost zemljišta trajno održava u optimumu za date stanišne uslove, da privredi stavi na raspoloženje drvnu masu, koja bi u šumi najčešće propala, i da osigura trajnu proizvodnju maksimalne količine drvne mase, koja i po vrijednosti treba da je visoka.

O potrebi njege šuma danas se u krugovima šumarskih stručnjaka mnogo govori, jer su i mišljenja podijeljena. Dok jedni smatraju da pri današnjoj tehnologiji prerade kvalitet nije od značaja, drugi, koji su mnogobrojniji (Dekanić, 3; Koestler, 8,9; Leibundgut, 10; Hilf, 7; Petrović, 12; Pintarić, 15; Schaedelin, 16, i dr.) smatraju da je njega šuma neophodna iz više razloga: održava se ili čak i povećava plodnost zemljišta; povećava se kvalitet, a samim tim i vrijednost proizvodnje; u sastojini se održavaju bolji genotipovi; itd.

Protivnici njege šuma zasnivaju svoje mišljenje uglavnom na činjenici da je proizvodnja biomase stalna veličina i da se ona ne može povećavati njegom, što je i tačno, ali pri tome zaboravljaju da se samo njegom može vrijednost proizvodnje znatno povećati, jer prema Hilf-u (7), cilj proizvodnje u šumarstvu Srednje Evrope treba da budu vrijedniji sortimenti jer za to postoje povoljni uslovi, dok proizvodnju isključivo biomase bez obzira na kvalitet, treba prepustiti zemljama koje se nalaze u nepovoljnijim ekološkim, posebno klimatskim uslovima, kao što su Skandinavske zemlje ili sjeverni dijelovi euroazijskog odnosno sjevernoameričkog kontinenta (Pintarić, 15).
Problemi uredjivanja visokih šuma hrasta kitnjaka u SR Srbiji
Authors: Milin Živojin
Published: August 2023

U brdsko-planinskom području SR Srbije van autonomnih pokrajina, javljaju se uglavnom četiri vrste hrasta i to: Quercus sessilis-kitnjak; Quercus cerris-cer, Quercus conferta-sladun, krupna granica i Quercus pubescens-medunac, sitna granica. Nabrojani hrastovi javljaju se u tri privredno značajne asocijacije i to:

Querceto-Carpinetum serbicum Rud.-srpska šuma kitnjaka i običnog graba,

Quercetum montanum serbicum Čer et Jov srpska šuma kitnjaka, i

Querceto confertae cerris Rud. šuma hrasta cera i sladuna.

Ostale asocijacije u kojima se ovi hrastovi javljaju, nemaju uopšte neki privredni značaj, te ih zbog toga i ne navodimo. Medjutim, nemaju svi navedeni hrastovi, a prema tome ni asocijacije u koje ulaze, ni približno isti privredni značaj. Tome je najviše doprineo čovek svojim uticajem. Prema Jovanoviću (1956.): "Areal šuma smanjen je odozdo, kraj ljudskih naselja, uglavnom u pojasu hrastova, prvenstveno radi potreba poljoprivrede" i dalje: "šuma hrasta cera i sladuna najvećim delom je iskrčena u Srbiji, preostali su zabrani sa kojima se gazduje kao sa niskom izdanačkom šumom".
EU FAST TRACK MEMBERSHIP: CAN IT HELP UKRAINE RESOLVE ITS REAL PROBLEMS?
Authors: Siddiqi Houma
Published: August 2023

In 1991, during its inception process, Ukraine faced Russia's territorial claims and a cold reception from the Western world towards its leadership. After evaluating its internal and external interests, Ukraine chose to sign a friendship and cooperation agreement with Russia, compromising its rights as a sovereign state. This decision kept the complex issues of cross-border irredentism and multiple identities in check. However, during the democratic transition, external actors got involved in Ukraine's domestic politics, resulting in the removal of President Yanukovych's government. This critical juncture set the trajectory for unleashing Ukraine's state-ness issues. External involvement and political mismanagement aggravated Ukraine's problems and transformed its political issues into state-legitimacy issues, making its claim of a single entity void. Without state legitimacy, Ukraine cannot join the EU or consolidate as a democracy. Even if it enters the EU, it cannot safeguard its state sovereignty or achieve a profitable deal. This post-positivist research uses process tracing within a case study to highlight Ukraine's real problems and whether EU membership can help resolve them. The best solution for Ukraine is to focus on its domestic issues and negotiate with the other actor for a peaceful solution.
 
Bibliography Entry
Siddiqi, Houma. 2023. "EU Fast Track Membership: Can It Help Ukraine Resolve Its Real Problems?" Margalla Papers 27 (1): 13-27.
HYPERSONIC WEAPON SYSTEMS – A NEW WAVE OF ARMS RACE IN THE INDIAN OCEAN REGION
Authors: Raza Imran , Mehmood Nasir
Published: August 2023

Technological advancements and tactical applications have always played a significant role in determining the outcomes of military conflicts. The emergence of Hypersonic Weapon Systems is considered a game-changer in contemporary and future warfare, as it can potentially dominate the early stages of conflict. Major powers like the US, China and Russia are pursuing technological superiority by developing hypersonic weapons, which could undermine conventional strategic capabilities and render even the most advanced air and missile defences obsolete. However, there has been limited discussion on the impact of deploying hypersonic weapons in the Indian Ocean region and its implications on strategic stability in the Pakistan-India military matrix. This paper examines the induction of hypersonic weapons by the Indian Navy, utilising insights from security dilemma and conventional deterrence theories to navigate the complex strategic landscape in the region. It contributes to the ongoing debate on the relationship between the arms race and conventional deterrence in Pakistan and India, highlighting the risks of an arms race in the Indian Ocean region. Without strategic dialogue on regulating hypersonic weapons systems, the chances of escalation and conflict could increase significantly.
 
Bibliography Entry
Raza, Imran and Nasir Mehmood. 2023. "Hypersonic Weapon Systems – A New Wave of Arms Race in the Indian Ocean Region." Margalla Papers 27 (1): 28-39.
REVISITING THAILAND'S PARANOIA: SEATO AS A SAFEGUARD AGAINST VIETNAM SYNDROME
Authors: Javed Tauseef , Jiandang Sun , Khurshid Ayisha
Published: August 2023

During the Cold War, the opposing stances of the US and USSR caused a bipolar global system that lacked a unipolar centre of power, leading to a stronger centrifugal pull. The Vietnam War made Southeast Asia a hotbed for these tensions. Following the fall of French troops in Dien Bien Phu in 1954, the US aimed to solidify its position and successfully created the Southeast Asia Treaty Organization (SEATO) through the efforts of Secretary of State Dulles and like-minded nations. To explain the political implications, the Michael Brecher geographical framework has been chosen. This framework highlights the dominant and subordinate systems of international relations during the Cold War period and describes the operation and evolution of SEATO. By incorporating guidelines into the charter, the treaty zone became a space where signatories could resolve their issues. This reference framework helps to identify the causal determinant in the stimuli of an individual signatory. Despite being a group of countries with varied interests, the interaction between the US and Thailand during the Vietnam War showed that Thailand's skilful aggregation of marginal gains resulted from its inherent paranoia against the Vietnam syndrome. Furthermore, the study reveals that Thailand had a significant influence in shaping Washington's policy for Southeast Asia and used its gains as a launching pad to control the spread of Communism.
 
Bibliography Entry
Javed, Tauseef, Sun Jiandang and Ayisha Khurshid. 2023. "Revisiting Thailand's Paranoia: SEATO As a Safeguard Against Vietnam Syndrome." Margalla Papers 27 (1): 138-154.