bluuebunny/crossref_metadata_2025 huggingface dataset:
Closed classes in partial k-valued logic
Authors: Alekseev Valerii Borisovich
Published: December 2024

The article gives an overview of the main known results on closed classes in partial k-valued logic. The main emphasis is on intervals of closed classes in partial k-valued logic, generated by some closed class A in the set of everywhere defined k-valued functions. Results on Lau intervals are presented, as well as recent results on intervals Int(A) introduced by the author. Some results are given with full proofs.
On circuit complexity of partial Boolean functions
Authors: Chashkin Alexander Viktorovich
Published: December 2024

We estimate the circuit complexity of partial Boolean functions of a given weight in an arbitrary complete finite basis B, where each basis function φi is assigned a positive weight ρi, and the complexity of a circuit is the sum of the weights of all its gates. For any partial n-place Boolean function f defined on a domain of D≥n elements as equal to unity on N tuples from this domain, it is shown that as n→∞ LB(f)≲ρ•(log2(DN)/log2log2(DN))+O(n) where ρ is the minimum of reduced weights ρi/(ri-1) of B taken over all nonunary gates of B.
Os excluídos e marginalizados na Idade Média e no presente
Authors: Menezes Neto Geraldo Magella de
Published: December 2024

O presente artigo traz práticas de ensinode História na Educação de Jovens e Adultos(EJA) desenvolvidas no ano de 2023 naEscola Estadual Ruth Passarinho, em Belém.Devido às especificidades do públicoatendido e de sua difícil realidade, semapoio do poder público, o professor deHistória que trabalha na EJA deve construirum currículo e selecionar conteúdosque sejam significativos aos alunos. Assim,para trabalhar questões importantes,que estimulassem a reflexão e a crítica,elaboramos em primeiro lugar um questionáriopara conhecer melhor o públicoda EJA em uma turma da 4ª etapa do fundamental.Nesse processo, foi construídauma proposta temática de abordagem, intitulada“Os excluídos e marginalizados naIdade Média e no presente”, com o objetivode abordar as camadas sociais excluídas no passado fazendo relações com o presentea partir dos olhares dos educandos.
“Yakera Jakitane Saba Nonate”
Authors: Oliveira Tatiana , Medeiros Lucineide Barros
Published: December 2024

Este artigo é uma análise crítica das experiênciasde alfabetização dos indígenas venezuelanosda etnia Warao na cidade deTeresina, Piauí. Nosso objeto de análiseserão três projetos desenvolvidos com essessujeitos: Ciranda Latina; Alfabetizaçãosem Fronteiras e EJA Intercultural. Utilizaremostambém algumas entrevistas concedidaspor participantes desses projetospara problematizarmos os avanços e desafiosda alfabetização dos Warao, tendo emvista as barreiras linguística e cultural e asituação de abrigamento que perpassam aexperiência educacional desse grupo étnicoem outro país. A identidade indígena éum marcador social importante para compreendermosas dificuldades em propor,de fato, uma educação que seja emancipadorae diferenciada.
Um professor negro em Cambridge: Entrevista com Jason Arday
Authors: Pereira Amilcar Araujo
Published: December 2024

Jason Arday é sociólogo e atualmente é a única pessoa negra atuando como professor titular na Faculdade de Educação da prestigiosa Universidade de Cambridge, no Reino Unido. Ele nasceu num subúrbio de Londres, em 1985. Filho de pais africanos, crescendo em uma família pobre, aos 3 anos de idade recebeu o diagnóstico de autismo e atraso global de desenvolvimento. Jason tinha ainda problemas auditivos em um dos ouvidos, o que contribuiu para que ele só começasse a falar quando já tinha 11 anos, graças à ajuda fundamental da sua mãe, que usava músicas diversas para ajudá-lo no desenvolvimento da linguagem. Jason somente aprendeu a ler e escrever quando já tinha 18 anos de idade. Formou-se em Educação Física na Universidade de Surrey e logo fez 2 mestrados, um deles seguido pelo doutorado em Educação na Universidade de Liverpool John Moores, em Liverpool, no Reino Unido. Em março de 2023, aos 37 anos de idade, tornou-se um dos mais jovens professores titulares da história de Oxbridge, como chamam no Reino Unido as universidades de Oxford e Cambridge, as duas mais antigas, mais ricas e mais prestigiosas universidades daquele país. Embora ainda muito jovem, Jason já tem vários livros e artigos publicados, conquistou grande reconhecimento por seu trabalho, tanto o acadêmico quanto seu trabalho para a arrecadação de recursos para a caridade, e rapidamente tornou-se uma das principais referências no debate sobre relações raciais, racismo, desigualdades e educação no Reino Unido.
Traumatic Anterior Hip Dislocation With an Open Book Pelvic Fracture and Femoral Artery Compression
Authors: Gomez-Sierra María Antonia , Martinez-Rondanelli Alfredo , Palacio Laura , Martinez-Cano Juan Pablo
Published: December 2024

Case:

A 34-year-old patient was involved in a motorcycle accident, resulting in an anterior hip dislocation associated with an open book pelvic fracture and compression to the femoral artery. He required an emergent closed reduction of the hip dislocation and open reduction and internal fixation of the pelvic fracture.

Conclusion:

This case underscores the importance of maintaining a high level of suspicion for anterior hip dislocation, particularly in patients involved in motorcycle accidents, where a flexed, abducted, and externally rotated hip is common. Timely diagnosis allows for prompt treatment, leading to better functional prognosis and improved survival opportunities.
Automated Balanced Cable Trifocal Bone Transport
Authors: Haruno Lee S. , Owen Jonas K. , Marecek Geoffrey S.
Published: December 2024

Case:

A 14-year-old adolescent boy sustained a Gustilo-Anderson Type 3A tibia fracture treated with medullary nailing. He developed an atrophic nonunion with a 10.5-cm defect after debridement. An automated hexapod system was adapted to perform trifocal tandem cable transport. Transport proceeded at 0.75 mm/day per focus, segmented into 16 increments. Docking and conversion to a nail occurred 103 days after frame application for an external fixation index of 9.8 days/cm.

Conclusion:

Automated balanced cable transport is a viable option for segmental bone defects. This is the first reported automated balanced cable transport.
Rare Presentation of Chondroblastoma of the Patella, a Case Report
Authors: Fang William H. , Fan Juston , Nael Ali , Misaghi Amirhossein
Published: December 2024

Case:

Chondroblastoma, a rare benign bone tumor, often occurs in skeletally immature individuals, with patellar involvement in <2% of cases. We report a 14-year-old adolescent boy with anterior knee pain and a patellar chondroblastoma. Imaging revealed a radiolucent lesion, and biopsy confirmed the diagnosis. Curettage and grafting led to pain resolution, full range of motion, and sports clearance at 6 months with no recurrence.

Conclusion:

Patellar chondroblastomas are exceptionally rare, usually arising in long bone epiphyses. Differential diagnosis includes Langerhans cell histiocytosis, giant cell tumors, and clear cell chondrosarcoma, requiring histological and imaging analysis. Recurrence risk mandates ongoing clinical and radiological monitoring.
Restoration monitoring metric framework: integrating innovative remote-sensing technologies : comparisons between field and remotely sensed vegetation surveys of restored forested and grassland sites in Ohio
Authors: Theel Heather , Reif Molly , Hinck Jo Ellen , Skrabis Kristin , Altman Safra , Grabner Keith , Stroh Esther , Tillitt Robin , Saltus Christina , Beane Nathan , Jackson Samuel , Bourne Scott , Laird Jennifer , Hammond Shea , Matheson Kenneth , Berry Thomas
Published: December 2024

Restoration monitoring is generally perceived as costly and time-consuming, yet the concept of universal restoration monitoring metrics is trending for evaluation of restoration performance across spatial scales, project boundaries, and jurisdictions. Natural Resource Damage Assessment and Restoration (NRDAR) practitioners seek to restore natural resources injured by oil spills or hazardous substance releases into the environment. Therefore, a multiagency team [US Army Engineer Research and Development Center (ERDC), US Department of the Interior (DOI), and US Department of Energy (DOE)] developed and field-tested a multitiered monitoring framework, illustrating a range of field and remote-sensing techniques and methodologies. The restoration monitoring framework and field demonstration offer a unique methodology to acquire and evaluate simultaneously collected, multiscale/multiplatform data. The result of this research provides new insights to (1) assist planning, implementing, and monitoring restoration progress and effectiveness; and (2) apply common monitoring methods, endpoints, and metrics to other types of ecosystem restoration initiatives. Although the aim was to inform monitoring and management of areas that had been injured, these methods could also be used to inform restoration monitoring practices in a broader context, benefiting environmental stewardship missions of all project partners.
R.D. No. 079-DGIDI-CIENTIFICA-2024 Tesis patente o software 2025-1
Authors:   Universidad Científica del Sur
Published: December 2024

Resolución directoral No. 079 -DGIDI-CIENTIFICA-2024 - Beca Cabieses para tesis en la modalidad patentes o software para pregrado y posgrado 2025 - 1
WITHDRAWN: On Practical uniform of perturbed triangular system of two differential equations named by integral input stat stable system
Authors: Moter Amany M. , Ellouze Ines
Published: December 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Statistically Enhanced Learning: a feature engineering framework to boost (any) learning algorithms
Authors: Felice Florian , Ley Christophe , Bordas Stéphane P.A. , Groll Andreas
Published: December 2024

Feature engineering is of critical importance in the field of Data Science. While any data scientist knows the importance of rigorously preparing data to obtain good performing models, only scarce literature formalizes its benefits. In this work, we present the method of Statistically Enhanced Learning (SEL), a formalization framework of existing feature engineering and extraction tasks in Machine Learning (ML). Contrary to existing approaches, predictors are not directly observed but obtained as statistical estimators. Our goal is to study SEL, aiming to establish a formalized framework and illustrate its improved performance by means of simulations as well as applications on practical use cases.
Is it a bat or a male? A female moth (Syntomeida epilais, Lepidoptera: Erebidae: Arctiinae) adapts its acoustic signals for defense or courtship
Authors: Coro Frank
Published: December 2024

Courtship behavior in the polka-dot wasp moth Syntomieda epilais is the most elaborate acoustic communication system known in the Erebidae. Both males and females must emit their acoustic signals for successful mating under natural conditions in the presence of insectivorous echolocating bats. Females of S. epilais were stimulated during their courtship period (between 02 ÷ 30 and 06 ÷ 30) with playback of conspecific male and female signals and of a sympatric bat attack sequence and their acoustic emissions were recorded. On the third night post-eclosion at the initiation of courtship behavior, females discriminate among these types of acoustic series, responding preferentially to conspecific male signals. In contrast, during the first two nights post-eclosion, they respond strongly to the bat attack sequence but not to conspecific male signals. It is demonstrated that post-mated female moths stop responding to conspecific male signals, while continuing to respond to the bat attack series. These and other novel observations suggest that these female moths can modulate their acoustic signals, according to the stimulating conditions for defense against bats or courtship, by varying their response thresholds and latencies.
Characterization of a non-specific lipid transfer protein from Betula platyphylla and identification of Bp ns LTPs response to drought stress
Authors: shi jingjing , Chen Shizhong , Gao yan , Gao caiqiu , Wang Chao
Published: December 2024

The non-specific lipid transfer protein (nsLTP) is a plant gene family that significantly influences plant growth, development, and adaptation to environmental stresses, particularly in response to biotic and abiotic stresses. This study characterized the nsLTP family and identified 23 nsLTP genes in birch (Betula platyphylla). Based on the sequence similarity and the presence of eight cysteine amino acid residues, BpnsLTP proteins were clustered into five types: type I, III, IV, V and VI. Seven nsLTPs were screened using by drought stress transcriptome analysis and qRT-PCR results proved that three nsLTP genes were positively responded to drought stress and four nsLTP genes were negatively responded to drought stress. Co-expression and go enrichment analysis revealed that genes co expressed with LTP genes were enriched in which futher domastrated these LTP were invleved plant abiotic stress. Subcellular localization experiment showed that BpnsLTPI.3 proteins were localized on cell membrane. Obtaining BpnsLTPI.3 overexpressing birch transgenic lines through leaf disk method, after treating transgenic and wild-type lines with 10% PEG6000 stress, various physiological and biochemical parameters were assessed. It was observed that the drought tolerance of the transgenic lines was significantly lower compared to the wild-type lines. Specifically, NBT and Evans blue staining indicated more pronounced stress-induced damage in the transgenic lines than in the wild-type. Moreover, the transgenic lines exhibited lower levels of protective enzymes such as POD and SOD, while the content of MDA and H2O2 was higher in comparison to the wild-type lines. These results suggest that BpnsLTPI.3, under the PEG6000 stress treatment, modulates protective enzyme activities, scavenges reactive oxygen species, and maintains cellular integrity in a manner that ultimately diminishes the drought tolerance of the transgenic birch plants. These results provide new insights into the biological functions of the nsLTP family of B. platyphylla in response to abiotic stress.
Human immunocompetent microfluidic platform for in vitro testing in immuno-oncology applications
Authors: Modena Mario , Lohasz Christian , Häfeli Tamara , Hasanova Dzhansu , Hölting Lisa , Rudnik Michal , Lützow Svenja , Mehta Avni , Kritzer Bettina , Laternser Sandra , Nazarian Javad , Frey Olivier , Hierlemann Andreas
Published: December 2024

In vitro evaluation of novel therapeutic approaches often fails to reliably predict efficacy and toxicity, especially when recapitulating conditions involving recirculating cells. Current testing strategies are often based on static co-culturing of cells in suspension and 3D tissue models, where cell sedimentation on the target tissue can occur. The observed effects may then mostly be a consequence of sedimentation and of the corresponding forced cell-tissue interactions. The realization of continuous medium flow helps to better recapitulate physiological conditions. To tackle current limitations of perfused organ-on-chip approaches, we developed a microfluidic chip and operation concept, which prevents undesired sedimentation and accumulation of cells in suspensions over multiple days by relying on gravity-driven perfusion. Our platform, which we termed “human immune flow (hiFlow) chip”, enables to co-culture cells in suspension with up to 7 preformed microtissue models. The primary goal was to study flow-dependent recruitment of the circulating cells to the different tissue spheroids. Cells and tissues could be monitored on-chip via high-resolution microscopy, while cell suspensions and microtissues could be easily retrieved for off-chip analysis. Our results demonstrate that primary immune cells and spheroid models of healthy and diseased tissue can be maintained for over 6 days on chip. As proof-of-principle assay, we investigated the efficacy of antibody treatment against diffuse midline glioma, a highly aggressive pediatric tumor. We believe that our platform will help to increase the prediction power of in vitro preclinical testing of novel immunotherapeutics.
Do cyberbullies develop depressive symptoms? A longitudinal multi-study
Authors: Bansal Suhans , Garg Naval , Singh Jagvinder
Published: December 2024

Purpose
Researchers have adequately explored the impact of cyberbullying on the mental health of cyber victims. However, its ill effects on cyberbullies are yet to be examined sufficiently. Moreover, existing studies have not answered why cyberbullying leads to mental health issues among cyberbullies. Therefore, to bridge these gaps, this study examined the relationship between cyberbullying (two factors, HCA and GCC) and depressive symptoms among cyberbullies. Also, the study examined the mediating effects of guilt and fear as a mechanism that explains the development of depressive symptoms among cyberbullies.
Methods
Two studies (college students and working professionals) were conducted through three-wave data collection. The relationships between the two dimensions of cyberbullying and depression were examined using correlation and hierarchical regression analysis. Demographic variables like age and gender were used as control variables. Mediation effects were analysed using the PROCESS macro in SPSS.
Findings:
The correlation and hierarchical regression suggest that HCA and GCC significantly predict depressive symptoms among cyberbullies, and age and gender (control variables) are not significant predictors. The PROCESS macro results indicated a significant mediation effect of fear and guilt, thereby suggesting that they act as mechanisms explaining the development of depressive symptoms in cyberbullies.
Originality:
It is the first of its kind of study that suggests that cyberbullies also develop depressive symptoms out of their act of cyberbullying others. Secondly, it is a pioneer study that suggests guilt and fear can mediate the relationship between cyberbullying perpetration/attitude and depressive symptoms in cyberbullies, especially in the Indian context.
Research on RFID indoor location algorithm based on WPA-BP
Authors: REN JIE , JIANG LINGXIAO , ZHAO Ruinan
Published: December 2024

The conventional RSSI-based RFID positioning algorithm is extensively employed for indoor positioning. To enhance the accuracy of position coordinates and minimize errors, this paper proposes an innovative RSSI-based RFID indoor positioning algorithm that integrates the Wolf pack algorithm (WPA) and BP neural network. A WPA-BP hybrid neural network algorithm is the integration of WPA to optimize the weight and threshold of the BP neural network. Training samples for the BP neural network are derived from RSSI signal strength and tag coordinates measured by the RFID reader, while the WPA algorithm optimizes the threshold and weight values of the neural network, resulting in a WPA-BP neural network model algorithm. Compared with experimental results of indoor localization based on BP algorithm and WPA-BP algorithm, the results using WPA-BP hybrid algorithm reduces errors in RFID indoor positioning, mitigates the impact of environmental factors, and enhances overall performance based on RSSI.
Kenwords : indoor positioning ; neural network ; wolf pack algorithm; Radio Frequency Identification
Characterization of Qu-aroma of Medium-High Temperature Daqu from Different Production Areas Using Sensory Evaluation, E-nose, and GC-MS/O Analysis
Authors: Jie Deng , Zheng Jia , Li Xing , Huang Zhiguo , Huang Dan , Ye Guangbin , Luo Huibo
Published: December 2024

Qu-aroma is a critical quality indicator for medium-high temperature Daqu (MT-Daqu). Due to the differences in regional and environmental conditions, these differences are likely to cause variations in the Qu-aroma of MT-Daqu. Despite this, comprehensive research on the variations in Qu-aroma across different regions has been lacking. This study aims to address this gap to analyze the differences in Qu-aroma characteristics of MT-Daqu from seven distinct production areas. Sensory analysis identified seven broad aroma categories and 25 specific aromas characterizing the Qu-aroma of MT-Daqu samples. Chen aroma and roasted aroma were notably more prevalent in MT-Daqu samples from Sichuan compared to those from other regions (P < 0.05). In total, 123 volatile compounds were detected in MT-Daqu, with 46 classified as aroma-active compounds. Among these, 21 aroma-active compounds were identified as markers distinguishing Sichuan MT-Daqu from those produced in non-Sichuan regions, showing significant differences in their concentrations (P < 0.05). Additionally, six major aroma-active compounds were found to significantly contribute to the aroma differences between Sichuan and non-Sichuan MT-Daqu. This study delineates the distinct Qu-aroma characteristics of MT-Daqu from various SAB production areas. The insights gained from this research offer valuable guidance for optimizing flavor profiles in MT-Daqu production.
Mixed infection with Colletotrichum species and Alternaria alternata causes fruit rot on processing tomato fruits
Authors: Hariya Atsuki , Maeda Kazuya , Osaka Masaaki , Iwao Eishin , Imano Sayaka , Asano Satoshi , Kubo Yasuyuki , Iida Yuichiro
Published: December 2024

Severe fruit rot was observed on ripe processing tomatoes in an open field in Japan. Round, sunken lesions formed on the fruits, with numerous black conidia in the center; the rot eventually expanded, sometimes over the entire fruit. Fungal isolates from lesions on the fruits were identified as Colletotrichum cliviicola, C. fioriniae and Alternaria alternata based on phylogenetic analysis. Isolates of C. cliviicola and C. fioriniae caused sunken lesions with ochre to blackish colonies on ripe but not unripe tomatoes. The A. alternata isolates also caused sunken lesions with white to blackish colonies only on ripe fruits. Thus, C. cliviicola, C. fioriniae, and A. alternata caused the fruit rot on processing tomatoes. Sequential inoculation of processing tomato fruits with C. cliviicola and A. alternata also caused symptoms similar to those in the field, suggesting that a mixed infections can lead to this severe fruit rot.
Inclusion complexes of serotonin and dopamine with a dioxa-pentaaza-cyclophane
Authors: Moreno-Pérez Teresita , Valencia Ángel U. Orozco , Soberanes Yedith , Sotelo-Mundo Rogerio R. , Inoue Motomichi , Santacruz Hisila , Navarro Rosa E.
Published: December 2024

In attempt to find new type of artificial receptors towards neurotransmitters, NMR studies were carried out on the supramolecular complexation of serotonin and dopamine with a dioxa-pentaaza-cyclophane derived from diethylenetriaminepentaacetic acid (known as DTPA); at the pH 7.2, the macrocycle composed of three phenylene groups is negatively charged with three anionic -CH2CO2− arms, whereas the aromatic neurotransmitters carry a cationic -NH3+ group. Aromatic protons in the cyclophane exhibit up-field shifts due to the ring current effect of the neurotransmitters in NMR titration; the through-space interaction is confirmed by NOESY (Nuclear Overhauser Enhancement and Exchange Spectroscopy). Geometry optimization shows that the macrocycle can encapsulate either neurotransmitter molecule to form a 1:1-inclusion complex in which electrostatic and hydrogen-bonding interaction operate between the functional groups of the component molecules. The through-space interaction is stronger for serotonin because of its better fitness to the macrocyclic cavity. The thermodynamic stabilities of the complexes are about 20 M− 1 in D2O, and are very slightly decreased in the coexistence of electrolytes. The complexation is promoted by the electrostatic and hydrogen bonds. The resulting ion-pair is stabilized by the successive encapsulation, which protects the weak bonds against the electrostatic field of the electrolyte. The combination of multiple types of interacting sites may be crucial in the design of receptors that can function under isotonic conditions.
Nano-Emulsification of PTX and BEZ235 inhibit colon cancer growth
Authors: Zhu Xingyao , Zhang Ruiqi , Liu Yuhua , Yang Caiyun , Ding Qi , Gu Wenyi , Zou Hong
Published: December 2024

As the most common malignant tumor, colorectal cancer is a serious threat to people's health, especially the problem of drug resistance, is a huge challenge. In previous studies, we have found synergistic anti-colon cancer effects with the combination of paclitaxel and BEZ235, especially for drug-resistant colorectal cancer with excellent anti-tumor effects. Therefore, this study aims to investigate the preparation of Nano-Emulsification of paclitaxel and BEZ235 (NEs-PTX-BEZ235), and to explore the potential key parameters of its clinical transformation. To provide a new therapeutic strategy for colorectal cancer, especially for drug-resistant colorectal cancer. The nanomaterials were prepared by low energy self-emulsification method, and analyzed by Malvern laser particle size analyzer. Cell drug uptake was observed under fluorescence microscope. CCK8, Western blot and flow cytometry were used to compare the anti-cancer effects and mechanisms of different experimental groups on ordinary and drug-resistant colon cancer cells. Human colon cancer primary cells were extracted to verify the anti-tumor effect of drugs. Finally, we found that NEs-PTX-BEZ235 significantly killed colon cancer cells, especially drug-resistant cells, and better than Nab-PTX. It may play a synergistic role in reducing drug resistance, inhibiting tumor stemness and inducing apoptosis of colon cancer cells by inhibiting drug resistance proteins.
Scaling up medications for opioid use disorder in Kentucky: Qualitative perspectives of treatment organizations
Authors: Knudsen Hannah K. , Andrews-Higgins Shaquita , Back-Haddix Sandra , Lofwall Michelle R. , Fanucchi Laura , Walsh Sharon L.
Published: December 2024

Background
Underutilization of medications for opioid use disorder (MOUD), which reflects the limited number of patients initiating treatment and being retained in treatment, remains a persistent barrier to addressing the opioid epidemic. Using an adapted PRISM (Practical, Robust Implementation and Sustainability Model) framework, this study describes multi-level barriers and facilitators to expanding MOUD as part of the HEALing (Helping to End Addiction Long-term®) Communities Study in Kentucky (HCS-KY).
Methods
Cross-sectional small group and individual semi-structured interviews were conducted with 60 employees representing 30 MOUD agencies in eight Kentucky counties from December 2022 to June 2023. A deductive-dominant approach to interviewing, with all interviews recorded and transcribed. Using a codebook informed by the adapted PRISM framework, a directed consensus-based approach to coding and thematic analysis was used.
Results
Although some agencies had a fairly static number of patients, most described recent experiences with modest growth in MOUD census and the ability to provide same day/next day MOUD. Multi-level factors, including organizational, patient-level, and community characteristics and perspectives, were perceived to impact MOUD census. Organizational characteristics impacting growth included the physical space of the clinic and staffing. Organizational policies in some agencies constrained treatment retention, while other agencies implemented innovations to better meet patients’ needs. Patients often encountered numerous challenges to treatment initiation and retention, including limited access to transportation, technology, safe and stable housing, and childcare. These patient-level barriers often reflected community characteristics, while community stigma also impeded MOUD growth.
Conclusions
These qualitative data revealed that some degree of growth in MOUD has occurred, but multi-level barriers are impeding further increases in treatment initiation and retention. Some barriers likely require policy changes related to financing and regulation, while other barriers require community-level efforts to decrease stigma and greater community investment in infrastructure, such as transportation and housing.
Trial registration
ClinicalTrials.gov, NCT04111939. Registered 30 September 2019,
Exploring the Relationship of Glucose and Keloid: a Comprehensive Mendelian Randomization Study
Authors: Cao Jiaojiao , Hu Chenglu
Published: December 2024

Keloid, a prevalent disorder of dermal fibroproliferation, manifests as benign tumors with massive proliferation of fibroblasts and overabundance of extracellular matrix. The limited efficacy of existing keloid treatments underscores the critical need for novel therapeutic approaches and strategies. Alterations in glucose metabolism of keloid fibroblasts correlate with keloid progression. Mendelian randomization (MR) analysis is a potent and robust epidemiological statistical method that employs genetic variants as instrumental variables to assess causality. Nonetheless, the exact nature of the causal relationship between glucose and keloid is yet to be determined. In this study, we first used GEO data for differential expression analysis in keloid and normal tissues, GO and KEGG pathways enrichment analyses, and gene screening and PPI network construction. Subsequently, We performed MR analysis of glucose and keloid, and sensitivity analysis with MR analysis of key differential genes. Finally, single-cell analysis was used for cell type annotation, intercellular communication analysis, pseudotime analysis, and GSEA analysis. The results showed that different glucose levels displayed protective effects in keloid. In addition, there was a causal relationship between ENSG00000136111 (gene TBC1D4) and keloid and it manifested as a protective factor for keloid. Higher TBC1D4 expression favored the differentiation of normal endothelial cells and NK cells. Therefore, our MR analysis emphasized a robust causal relationship between glucose and keloid, and indicated glucose as a dominant protective factor for keloid, theoretically providing evidence for keloid prevention and treatment.
Dense-Stream YOLOv8n: A Lightweight Model Method for Real-Time Crowd Monitoring in Smart Libraries
Authors: Chen Zini , Xie Xuming , Qiu Taorong , Yao Yuelei
Published: December 2024

Crowd monitoring in the context of smart libraries is of great significance for resource optimization and service improvement. Addressing the challenges of insufficient accuracy and real-time performance in crowd detection under high-density and side-view scenarios in dynamic library environments, this paper proposes a crowd detection method based on an improved YOLOv8n model. First, side-view crowd videos from different time periods in the library were collected, segmented into images, and manually annotated to generate a high-quality training dataset. Then, a lightweight convolutional data augmentation module called DensityNet was designed to enhance the model's feature extraction capabilities in crowded occlusion scenes. Subsequently, model pruning and knowledge distillation techniques were combined to reduce model complexity and improve detection real-time performance, adapting it to the computational requirements of edge devices. Finally, a region detection algorithm was designed to better accommodate the needs of crowd monitoring in high-density and constrained-view dynamic environments by extending the detection trigger time, thereby providing an accurate and contactless solution for people flow monitoring in smart libraries. Experimental results show that the improved YOLOv8n model achieves an average precision (mAP@0.5) of 0.99 in high-density scenarios, close to the original model's 0.991, while achieving 0.861 in mAP@0.5:0.95, an increase of 0.014 over the model before pruning; in terms of real-time performance, the frame rate (FPS) significantly increased to 254, with computational costs reduced to 4.0 GFLOP and the number of parameters decreased to 2.04M, meeting the real-time detection needs of peak crowd environments in smart libraries. This study addresses the unique people flow monitoring requirements of smart libraries by proposing an efficient and accurate solution, which not only optimizes resource and service management but also provides new technical support for the intelligent management of other domains.
A new C-eigenvalue localization interval for piezoelectric-type tensors
Authors: Xu Yangyang , He Guinan , Shao Licai , Chen Zimo
Published: December 2024

Given a piezoelectric-type tensor, its C-eigenvalues which play an important role in piezoelectric effect and converse piezoelectric effect of physics are always real and existed. In this paper, a new C-eigenvalue localization interval for piezoelectric-type tensors is presented. The newly proposed C-eigenvalue localization interval for piezoelectric-type tensors improves the previous one in [C-eigenvalue inclusion theorems for piezoelectric-type tensors, Appl. Math. Lett., 89(2019) 41-49]. To further examine the effectiveness and validity of the main result, some numerical experiments are considered by comparing with some previously known results.
AMS subject classifications: 15A69, 15A18, 15A42.
Power Control Scheme of Reconfigurable Intelligent Surface-Assisted Wireless Communication System Based on Millimeter-Wave Radar
Authors: Wenyu Luo , Annan Xuan , Tianze Yan , Xia Shao
Published: December 2024

To address the problem of excessive communication system overhead caused by high path loss, low scattering, and frequent switching of high-band communication in complex dynamic wireless environments, a reconfigurable intelligent surface (RIS)-assisted wireless communication system power control scheme based on frequency-modulated continuous-wave millimeter-wave radar (FMCW) is proposed. This paper proposes a power optimization scheme that senses dynamic users and characterizes dynamic environments.The FMCW radar is used to perceive the user and obtains dynamic position information about the user. To maximize the expectation of the signal-to-noise ratio (SNR) of the communication, the upper bound of the system interruption probability is obtained by analysing the effect of the user's location on the system reliability. Moreover, considering the influence of the multipath effect on the system gain, a geometric channel model is established to better reflect the dynamic environment under the multipath effect. Subsequently, while conforming to the constraints of the communication system, the power optimization method based on the binary search algorithm was adopted. Finally, the influence of the FMCW radar perception error on the power control results was analysed, and the error value of the power required for transmission by the base station was 0.4-0.5 dB within the error range. The simulation and analysis results show that the power required for base station transmission obtained using the proposed scheme is approximately 4 dB, which can effectively reduce the power required for system base station transmission.
The Impact of Health-Caregivers Emotional Nurturance on Cognitive Development in Preschoolers: A Nationwide Public Health Cross-Sectional Study
Authors: Sharma Prakash , Adamopoulos Ioannis , Syrou Niki , Budhathoki Chitra Bahadur , Thapa Pramila
Published: December 2024

Background: Early childhood cognitive development is influenced by a range of socio-economic, emotional, and environmental factors. This study investigates the association between emotional nurturance and cognitive development in preschool-aged children in Western Tarai of Nepal.
Methods: A cross-sectional study was conducted with 391 preschoolers from diverse socio-economic backgrounds. Cognitive outcomes were assessed, and socio-economic data, including Health-caregiver education, occupation, caste/ethnicity, and family structure, were analyzed alongside emotional nurturance scores. Multivariate linear regression models were used to assess the associations, adjusting for relevant covariates.
Results: Age and certain socio-economic factors were significantly associated with cognitive outcomes. Children aged 36–48 months showed notably higher cognitive scores compared to older age groups, and children from joint families scored higher than those from nuclear families. Additionally, children from disadvantaged caste backgrounds (Dalit and Janajati) demonstrated lower cognitive outcomes compared to those from advantaged castes, highlighting ongoing disparities. Emotional nurturance was positively but not significantly associated with cognitive development after adjustments.
Conclusion: Socio-economic disparities, particularly caste and family structure, play a critical role in shaping cognitive outcomes among young children in Nepal. The findings underscore the need for policies targeting socio-economic inequities to promote equitable cognitive development, and Population preventive Public Health especially in pre-school children. Supportive interventions focusing on joint family systems and educational opportunities for mothers may further enhance cognitive outcomes in rural settings.
Highly efficient cerium metal organic frameworks (Ce-UiO-66) and its inorganic hybrids nanocomposite as novel heterogenous catalyst for Knoevenagel condensation reaction
Authors: BOYNITO DINGETEGNA GODANA , TADDESSE ABI M. , G. Neelaiah Babu
Published: December 2024

Heterogeneous catalysis is a prominent application of metal-organic frameworks (MOFs), which have garnered significant interest from researchers over the past two decades due to their unique hybrid organic/inorganic nature. This study aimed to synthesize Ce-UiO-66 and its inorganic hybrids (CdS/Ce-UiO-66/Ag3PO4) and to assess their effectiveness as heterogeneous catalysts in the Knoevenagel condensation reaction. All materials were synthesized through hydrothermal methods and characterized using X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The organic components were analyzed with 1H-NMR and 13C-NMR spectroscopy. The catalytic performance of Ce-UiO-66 and its inorganic hybrids was evaluated under optimized conditions for various aldehyde substrates and malononitrile in aqueous media, focusing on reaction time, catalytic activity, and yield. The results showed that the yield of the target product followed this trend: T1 > CdS/Ce-UiO-66 > Ce-UiO-66. The catalytic system was also tested with various aromatic aldehydes, achieving over 90% conversion at room temperature. Additionally, the catalyst maintained its catalytic efficiency after being reused more than three times. Overall, this research highlights the synthesis of Ce-MOF and its inorganic hybrids and their catalytic performance in the Knoevenagel condensation reaction.
ИНТЕЛЛЕКТУАЛЬНОЕ ОСВОЕНИЕ КАВКАЗА В КОНТЕКСТЕ ОРИЕНТАЛИСТСКОГО НАРРАТИВА ПЕРИОДИЧЕСКОЙ ПЕЧАТИ 1820–1840 ГГ.
Authors: Ткаченко Д.С.
Published: December 2024

В статье анализируется ориенталистский дискурс нарратива, определявший логику и смыслы составления военно-политических и этнокультурных описаний событий на Кавказе и жителей региона. Источниками анализа стали публикации современников в центральных и региональных периодических изданиях первой половины XIX в. Периодические издания представляли читателям знания о своем регионе и транслировали четкие политические и культурные установки, легитимировали и усиливали сложившиеся отношения как внутри региональных сообществ, так и их с центральной имперской администрацией. Авторов статей различного содержания и политических взглядов, в описаниях народов региона объединяло использование ряда постулатов, терминов и методологических подходов, сложившихся в европейской колониальной практике XVIII–XIX вв. при описаниях Восточных культур.

The paper focuses on the study of Orientalist discourse in narrative, which determined the logic and meaning of compiling military-political and ethno-cultural descriptions of the Caucasus and its inhabitants. The sources of the analysis were the publications in central and regional periodicals of the first half of the 19th c. They provided readers with not only knowledge about their region, but also conveyed clear political and cultural guidelines, legitimized and strengthened the existing relationships both within regional communities and with the central imperial administration. The authors were united by the use of a number of postulates, terms and methodological approaches developed in European colonial practice of the 18th–19thc. in descriptions of Oriental cultures.
ОБРАЗ РОССИЙСКОГО ПАНСЛАВИЗМА НА СТРАНИЦАХ «LA NOUVELLE REVUE» (1879–1900 гг.)
Authors: Бодров А.В.
Published: December 2024

Статья выявляет основные черты образа российского панславизма последней трети XIX в. на страницах французского журнала «La Nouvelle Revue». Это издание последовательно пропагандировало русско-французское сближение во Франции. Одним из препятствий на пути к нему стояло укоренившееся во Франции отождествление российской политики на Балканах с агрессивным «панславизмом». Автор приходит к выводу, что «La Nouvelle Revue» последовательно продвигал позитивное восприятие «панславизма» как славянской солидарности, называя взаимные симпатии и тяготение друг к другу России и балканских народов объективной данностью. Основательница и бессменный руководитель журнала Ж. Адан кардинально меняла традиционный дискурс, называя освобождение балканских народов из-под иностранного владычества «фатальной миссией» России. В ее восприятии российская политика на Балканах и российские славянофилы как вдохновители этой политики были далеки от агрессивного аннексионизма. Все прежние клише о «русской угрозе» переносились французским изданием на Германию.

The article reveals the main features of the image of Russian Pan-Slavism created in the last third of the 19th century on the pages of the French magazine “La Nouvelle Revue”. This magazine consistently promoted Russian-French rapprochement. One of the obstacles to it was the deep-rooted French identification of Russian policy in the Balkans with aggressive Pan-Slavism. The author concludes that the magazine consistently promoted a positive perception of Pan-Slavism as Slavic solidarity, interpreting mutual sympathies and attraction of the Russian and Balkan peoples to each other as an objective reality. The founder and permanent head of the magazine J. Adam radically changed the traditional discourse, calling the liberation of the Balkan peoples from foreign rule a "fatal mission" of Russia. In her perception, Russian policy in the Balkans and Russian Slavophiles as the inspirers of this policy were far from aggressive annexationism. All the previous cliches about the "Russian threat" were attributed now by the French magazine to Germany.
ГУМАНИСТИЧЕСКИЙ СОЦИАЛИЗМ РОДОЛЬФО МОНДОЛЬФО
Authors: Щелчков А.А.
Published: December 2024

В истории левых сил существуют многочисленные лакуны, вытесненные из коллективной памяти доминировавшими политическими течениями, которые подавляли и вытесняли диссидентские и миноритарные по своему влиянию идейно-политические движения. Таким преданным забвению, «утраченным» звеном в эволюции левой, марксистской мысли является гуманистический социализм, ярким представителем которого был выдающийся итало-аргентинский философ, публицист Родольфо Мондольфо, чьи труды имели большое влияние на формирование «новых левых», на формирование концепций демократического социализма в Латинской Америке и Европе. В основе его идей лежало развитие философии праксиса в противостоянии с детерминизмом и волюнтаризмом ортодоксального марксизма. Его видение социализма ставило в центр внимания проблему преодоления отчуждения человека, товарного фетишизма капиталистической системы, проблемы моральной революции, свободы и демократии. Его труды в 60–70-е гг. находились в центре политических дискуссий среди «новых левых», в частности вокруг идейного наследия А. Грамши. Данная статья претендует на анализ его взглядов и дискуссий в левом интеллектуальном секторе в 1960–1970-е гг. в Латинской Америке.

In the history of left-wing forces, there are numerous lacunae that were ousted from the collective memory by the dominant political currents, which suppressed and displaced dissident and minority ideological and political movements. Such aforgotten and "lost" link in the evolution of left-wing, Marxist thought is humanistic socialism, a striking representative of which was the outstanding Italian-Argentine philosopher and publicist Rodolfo Mondolfo, whose works had a great influence on the formation of the "New Left" and on the formationof concepts of democratic socialism not only in Latin America, but also in Europe. His ideas were based on the development of the philosophyof praxis in oppositionto the determinism and voluntarism of orthodox Marxism. His vision of socialism focused on the problem of overcoming the alienation of the human, the commodity fetishismof the capitalist system, on the problems of moral revolution, freedom and democracy. In the 1960s and 1970s, his writings were at the centerof political discussions amongthe New Left, in particular around the ideological legacy of A. Gramsci. This article purports to analyze his views and discussions in the left-wing intellectual sector inthe 1960s and 1970s in Latin America.
ВОЕННАЯ ИСТОРИЯ В ПОИСКАХ НОВОЙ СОЦИАЛЬНОЙ РОЛИ ИСТОРИКА
Authors: Яковлев М.Е.
Published: December 2024

В статье рассматриваются особенности военно-исторических исследований в современной России на примере диссертаций на соискание степени доктора исторических наук, защищённых в 2014–2020 гг. Военно-исторические исследования по числу защищённых диссертаций представляют собой одну из самых больших тематических групп, охватывающую более десятой части от всех защищённых работ по истории в указанный период. Преимущественно диссертации посвящены российской истории XX в. с фокусом на истории развития различных типов вооруженных сил, и, в меньшей степени, истории Мировых войн. Автор указывает на своеобразие военной истории, выражающееся как в статистических отличиях от положения в исторической науке в целом, так и в особенностях специализации ученых и формулировки тематики их исследований. Особо отмечается практическая ориентированность военно-исторических работ – зачастую авторы выделяют в работе целый раздел, чтобы напрямую обратиться к органам государственной власти с экспертным заключением по той или иной области развития вооруженных сил России. Подобный переход от диссертации-исследования к диссертации–проекту нетипичен для исторической науки в целом и представляет собой новацию, а, возможно, некий ценностный сдвиг, уравнивающий стремление к истине с идеалом служения России.

The article examines the features of military history in contemporary Russia on the example of dissertations for the degree of Doctor of Historical Sciences, proved in 2014-2020. Military historical research on the number of defended dissertations is one of the largest thematic groups, covering more than a tenth of all defended works. The dissertations are mainly devoted to the Russian history of the 20th century, with a focus on the history of the development of various types of armed forces, and, to a lesser extent, the history of World Wars. The author points out the uniqueness of military history, expressed both in statistical differences from the situation in historical studies as a whole, and in the specifics of the specialization of historians and the formulation of the research topic. The practical orientation of military historical works is particularly noted - often the authors allocate an entire section in the work in order to directly address the state authorities with an expert opinion on a particular area of development of the Russian armed forces. Such a transition from a dissertation-research to a dissertation-project is atypical for historical studies as a whole, and represents an innovation, and perhaps some kind of value shift, equating the pursuit of truth with the ideal of serving Russia.