bluuebunny/crossref_metadata_2025 huggingface dataset:
Studierea influenţei componenţilor minori asupra eficienţei feromonilor sexuali ai viermelui mărului
Authors:   Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, Sleahtici Vladimir , Raileanu Natalia ,   Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, Odobescu Vasilisa ,   Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, Jalba Svetlana ,   Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, Costiuc Serghei ,   "Mezhtrans Moldova" SRL, Republic of Moldova
Published: November 2021

In this paper is reported the evaluation of biological efficacy of two minor components that was added to the basic sex pheromone component Cydia pomonella L., E8, E10-C12-OH. The use of minor component- C.M.-1 of increasing concentrations in binary mixture compositions with the basic sex phe-romone component of codling moth on pheromone-impregnated rubber septa in delta pheromone traps has shown an increased effectiveness by 56-62% in field trials on apple orchard. At the same time, the number of males caught in delta pheromone traps where were used minor component - C.M.-2 in binary mixture compositions increased by 29-35%. Auxiliary research is still needed.
Isolate locale ale baculovirului entomopatogenic ca o tehnologie de formulare inovatoare, care protejează biopesticidul din degradare a radiației ultraviolete
Authors:   Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, Stingaci Aurelia , Volosciuc Leonid ,   Institute of Genetics, Physiology and Plant Protection, Republic of Moldova
Published: November 2021

This paper presents the conceptual conceptual vision a formulation technology for biopesticides in which the active ingredient (baculovirus) is an active coal. Importantly, this indgredient protects the sen-sitive viral DNA from degrading in sunlight, but dissolves in the alkaline insect gut to release the virus, which then infects and kills the pest. We show, using this ingredient, in both laboratory bioassays and field tests, that this can extend the efficacy of the biopesticide well beyond the few hours of existing virus formulations, potentially increasing the spray interval and reducing the need for high application rates. Are presented both theoretical foundations and practical applications and described the results oriented for implementation and functionality of organic agriculture in Republic of Moldova.
Evaluarea calităţii biomasei de Lolium perenne L. Ca furaj și substrat pentru obținerea biometanului
Authors:   “Alexandru Ciubotaru” National Botanical Garden (Institute), Titei Victor , Blaj Adrian Vasile ,   Research-Development Institute for Grassland, Romania, Andreoiu Andreea Cristina ,   Research-Development Institute for Grassland, Romania, Marusca Teodor ,   Research-Development Institute for Grassland, Romania
Published: November 2021

We studied the biochemical composition, nutritive value of the green mass and prepared hay from Ro-manian cultivars of perennial ryegrass, Lolium perenne L. „Mara” and „Măgura” grown in monoculture on the experimental plot of the National Botanical Garden (Institute) “Alexandru Ciubotaru”, Chisinau, R. Mol-dova. Results revealed that dry matter of harvested green mass contained 98-116 g/kg CP, 299-326 g/kg CF, 71-77 g/kg ash, 329-353 g/kg ADF, 546-593 g/kg NDF, 38-40 g/kg ADL, 291-313 g/kg Cel, 217-240 g/kg HC, with nutritive and energy value 60.9-65.3 % DMD, 60.1-64.8 % ODM, RFV=96-108, 12.12-12.45 MJ/kg DE, 9.95- 10.23 MJ/kg ME and 5.97-6.25 MJ/kg NEl. The biochemical composition, nutritive and energy va-lue of prepared hay: 94-110 g/kg CP, 351-385 g/kg CF, 79-82 g/kg ash, 390-423 g/kg ADF, 631-689 g/kg NDF, 46-50 g/kg ADL, 344-373g/kg Cel, 241-266 g/kg HC, RFV=76-86, 11.13-11.61 MJ/kg DE, 9.14- 9.53 MJ/kg ME and 5.17-5.55 MJ/kg NEl. The biochemical methane potential of green mass substrates reached 338-344 L/kg organic matter. The studied cultivars of Lolium perennec could be used in the Republic of Mol-dova for the restoration of degraded permanent grasslands, as a component of the mix of grasses and legumes for the creation of temporary grasslands, the harvested biomass can be used as feed for farm animals or as substrate in biogas generator for renewable energy production.
Применение биологических препаратов в защите картофеля против возбудителя рака Synchytrium endobioticum (Schilb.) Perc. и золотистой картофельной цистообразующей нематоды Globodera rosthochiensis (Woll.)
Authors:   Ukrainian scientific-research plant quarantine station PPІ NAAS of Ukraine, Зеля А. , Макар Т. ,   Ukrainian scientific-research plant quarantine station PPІ NAAS of Ukraine, Зеля Г. ,   Ukrainian scientific-research plant quarantine station PPІ NAAS of Ukraine
Published: November 2021

The researches results of the following biological preparations Planrise, Paurin, Micosan, Actofit, Phitodoctor usage were presented. The biological preparations Planrise and Paurin (32,6%) against causa-tive agent of wart potato Synchytrium endobioticum (Schilb.) Perc. were shown the highest efficiency among the biological preparations by the research results. The efficiency of Phitodoctor consisted 25,8 %, Micosan was 23,1, respectively. The preparations efficiency were Micosan (42,8%), Phitodoctor and Paurin (30,2%); Actofit (34,3%); Bitobacsicillin (28,5%) against potato yellow cyst nematodes Globod-era rostochiensis (Woll.).
Israel Facing COVID-19
Authors: Cohen-Almagor Raphael
Published: November 2021

This paper considers Israel’s response to the challenges raised by the Covid-19 pandemic with a specific focus on the invoked public policies and the related political, economic and legal concerns. I first provide some background information. Then, I outline the keys for the initial success in confronting the coronavirus pandemic. Three factors contributed to the initial Israeli success, namely: the government’s swift and effective reaction to the pandemic; the close cooperation and coordination between the organisations that were mobilised to counter the pandemic, and the effective implementation of governmental policies. However, mistakes were made during the second wave of the pandemic.
Coronavirus Test of the European Union’s Policy on the Rule of Law
Authors: Gát Ákos Bence
Published: November 2021

The issue of the rule of law has been on the European Union’s (EU) agenda since the beginning of the 2010s. The legal history of the EU shows that the EU’s approach to the topic of the rule of law underwent significant changes. Initially, the Member States called for guarantees of fundamental rights in EU institutions. This trend began to change in the late 1990s and early 2000s, when the possibility of European rule of law control over Member States and the predecessor of the current Article 7 of the Treaty on European Union (TEU) were introduced by the Treaty of Amsterdam. However, the idea that the EU institutions can constantly monitor the Member States in the name of the rule of law has only emerged and started dominating the European political agenda since the early 2010s. Over the last decade, the EU institutions have continuously expanded their toolkit for monitoring Member States in this regard.Following calls from some Member States and the European Parliament, in 2014 the Commission set up the new EU framework to strengthen the rule of law. In the same year, the European Council introduced an annual rule of law dialogue. In 2016, the European Parliament proposed the establishment of an annual rule of law report that monitors all Member States. At first, the European Commission was reluctant to accept this idea, but finally it introduced an annual rule of law report in 2020. However, the EU’s policy on the rule of law suffers from fundamental shortcomings, which were especially visible during the first wave of the coronavirus crisis in the spring of 2020. In the pandemic situation, it has become even more apparent that the EU’s policy on the rule of law raises a significant issue of EU institutions exceeding their competences and stands on a questionable legal basis.Criticisms formulated against Hungary during the pandemic have revealed that the EU institutions do not provide sufficient guarantees for an objective examination of the situation of the rule of law in the Member States. The situation brought about by the coronavirus has also raised a number of questions regarding the lawful functioning of EU institutions, which shows the need for a rule of law mechanism capable of verifying that the EU institutions themselves also properly respect the rule of law.
A Covid Competition Dilemma: Legal and Ethical Challenges Regarding the Covid-19 Vaccine Policies during and after the Crisis
Authors: Hosseini Mina
Published: November 2021

The Covid-19 pandemic has impacted multiple facets of our lives and created a number of legal and ethical dilemmas. One of the greatest challenges at present is the production and distribution of the Covid-19 vaccine. Refusing to supply Covid vaccines widely could affect millions worldwide, and the pandemic may last for a long time. The competition authorities’ monitoring of the health sector in many countries has been subject to changes in thecurrent crisis. The question is whether we can force the Covid-19 vaccine manufacturers, legally and ethically, to sell their products and share their information with their competitors. Furthermore, what are the post-pandemic consequences of policies adopted during the pandemic? This paper employs a descriptive-analytical method to examine the importance of competition and intellectual property policies as they relate to Covid-19. It concludes that instead of focusing on individual rights in a crisis, public rights need to be emphasised. However, we should not underestimate the post-pandemic consequences of policies adopted during the Covid-19 pandemic.
Penerapan Metode Demonstrasi untuk Meningkatkan Hasil Belajar Siswa pada Mata Pelajaran Informatika Materi Operasi Dasar Komputer di SMAN 4 Kota Bima Kelas X MIPA 1 Semester Ganjil Tahun Pelajaran 2020/2021
Authors: Ruwaidah Ruwaidah
Published: November 2021

Penelitian ini mengangkat masalah keadaan awal keterampilan siswa di kelas X MIPA.1 SMAN 4 Kota Bima pada mata pelajaran Informatika materi operasi dasar komputer yang masih kurang memuaskan dengan penggunaan metode pembelajaran dimana proses pembelajaran masih berpusat pada guru dan pemberian tugas. Jenis penelitian yang digunakan adalah penelitian tindakan kelas yang terdiri dari dua siklus, dilakukan dua siklus karena target hasil belajar yang dicapai sudah dapat terlaksana pada siklus dua. Setiap siklusnya terdiri atas perencanaan, pelaksanaan, observasi, dan refleksi. Masalah penelitian ini adalah bagaimana Penerapan metode demonstrasi dapat meningkatkan hasil belajar siswa pada mata pelajaran Informatika materi operasi dasar komputer semester I di Kelas X MIPA.1 SMAN 4 Kota Bima Tahun Pelajaran 2020/2021? Hasil penelitian telah berhasil mendeskripsikan penerapan dengan menggunakan metode pembelajaran “Demonstrasi” dapat meningkatkan hasil belajar siswa pada mata pelajaran Informatika materi operasi dasar kompueter semester I di kelas X MIPA.1 SMAN 4 Kota Bima tahun pelajaran 2020/2021. Hal ini terlihat pada peningkatan aktivitas siswa pada proses pembelajaran serta peningkatan hasil belajar siswa pada mata pelajaran informatika materi operasi dasar komputer yang ditugaskan oleh guru setiap siklusnya. Peningkatan aktivitas  siswa  terlihat  sebagai  berikut:  pada siklus  I  rata-rata  dari  jumlah seluruh aspek yang  diamati adalah 53,7%, pada siklus II jumlah rata-rata  meningkat menjadi 80.0%. Sedangkan  peningkatan hasil belajar siswa yang terlihat  pada  ketuntasan  siswa dalam  menyelesaikan cara mengoperasikan komputer sebagai   berikut : sebelumnya  tanpa menggunakan  metode  demonstrasi  siswa yang  tuntas  10  orang  (33,3%)  dan  setelah menggunakan metode demonstrasi pada siklus I jumlah siswa yang tuntas 16 orang (53,3%), dan pada siklus II jumlah siswa yang tuntas mencapai 28 orang (93,3%).
Strategi Pengembangan Pasar Tradisional sebagai Daya Tarik Wisata di Kota Denpasar Bali: Study Kasus Pasar Kumbasari
Authors: Sutrisnawati Ni Ketut , A.A.A Ribeka Martha Purwahita  , I Ketut Saskara  , A.A. Sagung Ayu Srikandi Putri  , Putu Bagus Wisnu Wardhana
Published: November 2021

Perkembangan pariwisata di pulau Bali yang merupakan penyumbang devisa terbesar bagi Indonesia belum mampu memberikan manfaat ekonomi secara signifikan bagi masyarakat Bali. Hal ini terlihat dari meningkatnya jumlah penduduk miskin di Bali meliputi wilayah perkotaan dan perdesaan dari tahun 2012 hingga 2020, sebelum sektor pariwisata mengalami penurunan secara signifikan yang disebabkan oleh pandemi Virus CORONA. Berdasarkan kondisi tersebut maka perlu dilakukan pengembangan pariwisata yang lebih memprioritaskan pada peningkatan ekonomi masyarakat lokal Bali dengan melibatkan masyarakat lokal secara langsung pada pengembangan pariwisata. Salah satunya dengan mengembangkan pasar tradisional sebagai daya tarik wisata. Adapun yang melatarbelakangi upaya ini adalah karena pasar tradisional merupakan tempat transaksi jual beli dari seluruh lapisan masyarakat di Bali. Selain itu, pengembangan pasar tradisional menjadi tempat wisata diharapkan mampu bersaing dengan semakin banyaknya pasar modern yang tumbuh di Bali.  Lokasi penelitian yang dipilih adalah Pasar Kumbasari yang berlokasi di kota Denpasar. Pemilihan lokasi ini dilatarbelakangi karena Kumbasari merupakan salah satu pasar terbesar diBali dan saat ini dalam proses renovasi. Pasar ini pada masa sebelum pandemi Covid-19 beroperasi selama 24 jam dan menjadi tempat mencari nafkah bagi ratusan masyarakat Bali.  Strategi pengembangan ini menggunakan analisis SWOT (Strengths, Weaknesses, Opportunities, Threats). Faktor-faktor internal dan eksternal yang dimiliki oleh pasar tradisional khususnya pasar Kumbasari sebelum dilakukan renovasi dianalisa sehingga ditemukan berbagai kondisi baik itu berupa kekurangan/ kelemahan, ancaman, peluang dan kekuatan yang dapat dijadikan bahan pertimbangan dalam upaya peningkatan kualitas pasar pada saat dan setelah dilakukan upaya renovasi. Hingga akhirnya renovasi pasar Kumbasari dapat dilakukan sesuai dengan kebutuhan serta dapat dijadikan sebagai salah satu tempat yang layak untuk dikunjungi  wisawatan baik lokal maupun mancanegara, sehingga dapat memberikan manfaat secara maksimal bagi peningkatan ekonomi masyarakat Bali.
Asesoría científica y política pública: La gestión de la pandemia en Guatemala
Authors: Velásquez Pérez Luis Guillermo
Published: November 2021

Este artículo analiza la influencia de la asesoría científica en la gestión de la pandemia en Guatemala a través de una serie de valoraciones respecto al diseño y los alcances de la política sanitaria y laboral que fueron implementadas entre marzo y noviembre de 2020, así como de los actores que intervinieron durante el proceso. Para lograrlo se dividió en tres partes: antecedentes, análisis de la asesoría científica y conclusiones. En la primera se realiza una revisión general del estado de la ciencia y tecnología en Guatemala y una descripción de la reacción pronta del gobierno central ante el primer caso de Covid-19. En la segunda se discute y reflexiona en torno a la incidencia real de la asesoría científica, especialmente, la proveniente de Coprecovid en la formulación de las políticas mencionadas; y, finalmente, en la tercera se plantean las conclusiones generales respecto al papel de los actores que más incidieron en la gestión de la pandemia.
paradoxo do biopoder e a pandemia da COVID-19 na Amazônia: o caso de Manaus
Authors: Seabra Vlamir Nascimento , Karnopp Erica , Steyer Maria Raquel Pilar
Published: November 2021

Este artigo tem o objetivo de apresentar como a carência de investimentos em infraestrutura urbana, associado ao modelo de desenvolvimento econômico industrialista que concentrou investimentos na capital do Estado, atraindo uma boa parte da população para Manaus, gerou indicadores de desenvolvimento humano (IDH) baixíssimos, contribuindo enormemente para que a pandemia do Covid 19 se alastrasse na cidade de Manaus. Utilizando a teoria de Biopoder de Foucault que realiza uma crítica ao modelo liberal apresentamos a modernidade incompleta que desde do período áureo do extrativismo da borracha sempre foi excludente deixando milhares de pessoas invisibilizadas e carentes de políticas públicas que possam atender as suas necessidades básicas de saúde, educação e transporte.
La dualidad social en los estudios de opinión en Panamá (octubre de 2019-febrero de 2021)
Authors: Subinas Jon
Published: November 2021

Panamá ha destacado por su acelerado crecimiento entre 2004 y 2018 lo que ha tenido como consecuencia que en 2017 pasará a formar parte de los países de renta alta, pero este éxito económico no ha conseguido revertir, ni corregir las altas tasas de desigualdad. Con la irrupción de la pandemia se han hecho visibles las consecuencias de las desigualdades estructurales preexistentes. Entre las expresiones más destacadas de la inequidad podemos señalar la dualidad social. Esta dualidad se materializa en la opinión pública en una gran fractura social con dos modelos de país y opiniones muy divergentes sobre el rol de lo público y las medidas a adoptar para hacer frente a la pandemia.
Slovak Language Teaching in Italy in the Context of Slovak-Italian Cultural Relationships
Authors:   Comenius University in Bratislava, Kročanová Dagmar
Published: November 2021

The initial part of the paper describes the history of Slovak language and culture teaching in Italy, namely, Slovak lectorates at University of Naples L´Orientale, University of Rome Sapienza, and University of Bologna in Forlì. The central part of the paper discusses the foundation, development and activities of the most recent lectorate, founded in 2006, and currently affiliated with the Department of Interpreting and Translating at University of Bologna in Forlì. The paper mentions the circumstances related to the foundation of the lectorate, especially the message of Alexander Dubček (1921 – 1992) upon whom University of Bologna conferred the honorary doctorate in 1988. The paper discusses various activities of the lectorate (language teaching, research and publishing, promoting Slovakia and Slovak culture). It mentions the collaboration with Slovak and Italian institutions, including the Embassy of Slovak Republic in Rome, Slovak Institute in Rome and Honorary Consulate of Slovak Republic in Forlì. The final part of the paper mentions the current situation and perspectives of Slovak studies in Italy.
Digital Communication and Translation Problems (Based on Bulgarian and Russian Network Texts)
Authors:   amara National Research University named after academician S.P. Korolev, Karpenko Liudmila
Published: November 2021

The problem of equivalence of digital translation in the global Internet network is considered. The subject of the study is the errors of digital translation in texts posted on the Internet in the Facebook network. The method of comparative semantic-contextual analysis is used. As a result of the study of texts translated from Bulgarian into Russian, it was found that communication failures are observed at all language levels: lexical-semantic, word-formation, grammatical and at the level of value-modal assessment of the situation. Translation errors reveal the use of English as an intermediary language in the translation of Slavic texts in network systems. It is concluded that the improvement of digital translation models requires more attention to the lexical-semantic, word-formation and grammatical specifics of the Slavic languages, to their realities and language pictures of the world.
Оценката на качеството на средата за образование и грижа в ранното детство – предизвикателства и перспективи на съвременната практика
Authors: Атанасова-Трифонова Мария
Published: November 2021

В статията се предлага анализ на теоретическите положения, залегнали в определянето на различните аспекти на качеството на образователната среда, както и преглед на емпиричните изследвания в съвременната практика, което е ориентир за политиките за повишаване на качеството на образованието и грижата в ранното детство. Оценката на качеството на образователната среда преследва различни цели в различните страни, но е важна стъпка за разкриване на проблемните зони и тяхното по-нататъшно преодоляване. Специално внимание се отделя на различните измерения на качеството – структурни и процесуални, както и на необходимостта от изследване на сложните взаимовръзки между тях, които определят ефекта им върху резултатите на децата. Изясняването на обхвата и отделните измерения на качеството е необходимо за избора на методите за оценка и тяхното съдържателно съответствие на заложените критерии.
Paralytic stenosis of the larynx
Authors: Vokhidov U. N. , Shernazarov O. N. , Yakubdjanov D. D. , Djuraev J. A. , Sharipov S. S.
Published: November 2021

The aim of the study was to evaluate the effectiveness of various types of surgical treatment of patients with bilateral paralytic stenosis of the larynx. Study involved 28 patients aged 18 to 75 years, suffering from paralytic stenosis of the larynx, who was treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in the period from 2015 to 2020. The results of treatment with the use of laterofixation of the vocal fold, partial excision of the vocal fold in the posterior third and the vocal process of the arytenoid cartilage showed that after the above methods of surgical intervention, recurrence of stenosis occurs in 20-25% of cases, therefore it is necessary to develop tactics of surgical treatment and postoperative management of this category patients.
https://stratfordjournals.org/journals/index.php/Journal-of-Information-and-Techn/article/view/81018102t5028
Authors: Sargolzaei Masum Wang
Published: November 2021

New advancements especially in the field of information technology has actually brought new scientific gains to humans however it ought to be noted that the entry of new scientific and technological areas will constantly require to have ethical issues and restrictions. The purpose of the study was to analyze the ethical issues in computer as an instrument to technology growth in China. The study was literature review based. The participants of the study contained 20 computer system experts. 10 of them were graduates of computer education and educational technologies divisions, who worked as computer science instructors in China. Structured interviews were conducted with participants to identify their point of views concerning research study questions. Unauthorized access to the systems which is hacking is done utilizing different and new techniques and is increasing each day. Computer ethics has long been taken into consideration by the scientists. Interviews were organized separately with each participant in time slots and places they determined. The study concluded that computer ethics with a reference to personal privacy, accuracy, building and availability; investigated the beginnings of these issues; growth of internet and computer technology globally has resulted in the growth of new types of global criminal offense specifically Internet associated. The research suggested that the government of China should develop and apply a minimum set of directing rules of conduct that would certainly help with effective communications and reliable commerce via making use of electronic medium and to make certain the precision of data, in addition to shielding it from unauthorized accessibility or unintentional disclosure to improper people. Keywords: Ethical Issues, Computer, Technological Growth, China
ULTRASOUND PROMOTED L- PROLINE CATALYZED FACILE SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4H-CHROMENO[2,3-D] PYRIMIDINE DERIVATIVES INCORPORATED WITH QUINOLINE MOIETY
Authors: Patel A. J. , Patel M. P. ,   Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar - 388 120, Gujarat, India.
Published: November 2021

A simple, straightforward synthesis of 5-(2-chloro-6-substitutedquinolin-3-yl)-2-(4-substitutedphenyl)-8,8- substituted-5,7,8,9-tetrahydro-4H-chromeno[2,3-d]pyrimidine-4,6(3H)-diones (4a-l) has been performed by ultrasound irradiation method. Targeted compounds (4a-l) prepared from reaction of intermediate 2-amino-4-(2-chloro-6-substituted quinolin-3-yl)-7,7-substituted-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3- carbonitrile 2, which is synthesized by one pot three components way using L-proline as green catalyst at room temperature, was further reacted with benzaldehyde derivatives in the same reaction mixture under ultrasound irradiation at 70oC. In this process, cyclization occurred through elimination of water molecule followed by intermolecular cyclization and finally dimroth rearrangement. All synthesized compounds were screened for their antimicrobial activity. We confirmed the synthesized compounds (4a-l) using 1H NMR, 13C NMR, IR and mass spectroscopic methods.
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP MODELING FOR PREDICTION OF PYRIDINE SUBSTITUTED ANALOGUES WITH K-NEAREST NEIGHBOR STUDIES
Authors:   Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, Madhya Pradesh - 470 003, India., Sharma M. C. , Kohli D.V.
Published: November 2021

A quantitative structure activity relationship study was performed on a series of imidazo[4,5-b]pyridine substituted compounds as angiotensin II receptor antagonists for establishing quantitative relationship between activity and their physicochemical properties. The best quantitative structure activity relationship model was generated with correlation coefficient of 0.8318, cross validated correlation coefficient of 0.7142 and r2 for external test set 0.7965. Molecular field analysis was used to construct the best 3D-QSAR model using PLS method, showing good correlative and predictive capabilities in terms of q2 = 0.7264 and pred_r2 = 0.8164. These results will be useful for the design of new antihypertensive molecules.
STABILITY INDICATING LIQUID CHROMATOGRAPHIC ASSESSMENT OF DOLUTEGRAVIR BY AQBD APPROACH – CENTRAL COMPOSITE DESIGN
Authors: Sunitha G. , Anumolu P. D , Subrahmanyam C.V.S , Mounika G , Priyanka B. ,   Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Osmania University, Hyderabad - 500 090, Telangana, India.
Published: November 2021

Based on the current regulatory requirements for analytical method development, a RP-HPLC method for quality control of dolutegravir in dosage form has been optimized using analytical quality by design (AQbD) approach. Experimental observations were analysed by full factorial experimental design in Sigmatech software with two variables (flow rate and % organic mobile phase) whilst the number of theoretical plates was considered as response. The analytical method conditions were optimized as mobile phase (40:60 % V/V) consisting of acetonitrile and ammonium formate buffer, pH 3.0 pumped at a flow rate of 0.6 mL/min in an isocratic mode on SPOLAR C18 Column (250 x 4.6mm, 5μm) with run time of 15 min. The plot between peak area vs. concentration was rectilinear in the range of 5-30 μg/mL with detection and quantification limit values at 0.01 and 0.3μg/mL, respectively at retention time of 13 min. The predicted data from contour diagram for theoretical plates was verified virtually and it was contented with concrete experimental data. The method was validated as per ICH guidelines. The proposed method was pertinent for assay of marketed dosage form (Tivicay) and further extended to quantify the drug in prevalence of degradation products. Degradation pathways of dolutegravir were postulated and characterized by IR and mass spectral data.
INSILICO DOCKING APPROACH TO STUDY THE BINDING AFFINITY OF ISOFLAVONES ON THE CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA
Authors: Sharma Tripti ,   Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar - 751 030, Odisha, India.
Published: November 2021

The objective of the study was to carry out docking studies of isoflavone derivatives and examine their binding efficiencies to the ligand binding domain of ERα using Autodock program. A series of isoflavone derivatives were computationally designed and optimized with the AutoDock Vina software to investigate the interactions between the target compounds and the amino acid residues of the ERα.. In silico docking studies were carried out using AutoDock Vina, based on the Lamarckian genetics algorithm principle. The results showed that all the selected isoflavones showed binding energy ranging between -7.44 kcal/mol to -10.1 kcal/mol, when compared with that of the standard compound tamoxifen (-10.0 kcal/mol). Among all the designed compounds, 3-[3-(naphthalen-2-yl) phenyl]-2, 3-dihydro-4Hchroman- 4-one (Compound 12) shows more binding energy values (-10.1 kcal/mol). The present findings provide valuable information on the binding process of Isoflavones compounds to the binding site of ERα and reveal the structural requirement needed for binding.
SYNTHESIS OF NOVEL QUINAZOLIN-4(3H)-ONYL AZETIDINONES AS POTENTIAL ANTICONVULSANT AGENTS
Authors: Singh A. ,   Medicinal Chemistry Laboratory, Department of Chemistry, Meerut College, Meerut - 250 001, Uttar Pradesh, India.
Published: November 2021

A series of 4-(substituted aryl)- 1- [2’- methyl-6’- substituted anilino quinazolinon-4’-(3’H)-onyl ] -3- chloroazetidin- 2-ones 14-25 have been synthesized by addition of substituted anilines to 4-(substituted aryl)- 1- [2’- methyl-6’- bromoquinazolinon-4’-(3’H)-onyl ] -3- chloro- azetidin-2-ones 8-13 which in turn were prepared by the cycloaddition of triethylamine in dioxane to 3-(N-substituted benzylidene amino phenyl amido )-2-methyl-6-bromoquinazolin-4(3H)-ones 2-7 in presence of acetyl chloride. These compounds were screened for anticonvulsant activity and acute toxicity. Compound 4-(substituted aryl)- 1- [2’- methyl-6’- substituted anilino quinazolinon-4’-(3’H) – onyl ] -3- chloro-azetidinone showed most potent activity. The structure of all the synthesized compounds were delineated by elemental (C, H, N ) and spectra (IR, proton magnetic resonance and mass ) analysis.
SYNTHESIS, CHARACTERISATION, ANTIOXIDANT AND ANTICANCER EVALUATION OF NOVEL FLAVONE-4-OXIMES
Authors: Jayashree B. S , Sri Gurushyam , Pai A ,   Department of Pharmaceutical Chemistry Manipal College of Pharmaceutical Sciences Manipal University, Manipal - 576 104, Karnataka, India.
Published: November 2021

A series of novel flavone-4-oximes were synthesized by the oximation of substituted flavones. The synthesized compounds were characterized by various spectrochemical methods including IR, MS and NMR spectroscopy. Out of the 14 test compounds screened for their antioxidant activity, compounds such as JGS-VI (a N,N dimethyl benzaldehyde derivative) and JGS-VII (a 3,4 dimethoxy benzaldehyde derivative) exhibited antioxidant activity comparable to that of ascorbic acid and quercetin as standards following DPPH method. Compounds such as JGS-II (a p-fluoro benzaldehyde derivative), JGS-IV (a p-methyl benzaldehyde derivative) and JGS-V (a thiophene-2-aldehyde derivative) exhibited antioxidant activity among all the test compounds screened against ABTS. However, none of them showed any significant scavenging activity against nitric oxide scavenging assay in the concentration range of 200 μM-25μM. Further, anti-cancer potency for all the test compounds were evaluated by MTT assay against two different cell lines namely MCF-7 and Hep-G2. Compounds such as JGS-I (a p-chloro benzaldehyde derivative), JGS-II (a p-fluoro benzaldehyde derivative), JGS-IV, JGS-V (a thiophene -2-aldehyde derivative), JGS-VI and JGS-IX (a 3,4 chloro benzaldehyde derivative) exhibited activity better than the rest of the test compounds tested against MCF-7 cell lines. Compounds such as JGS-VI, JGS-VII, JGS-VIII (a p-bromo benzaldehyde derivative) and JGS-IX exhibited anti-cancer activity better than other test compounds tested against Hep-G2 cell lines. Thus, a few of the synthesized test compounds could become promising anti-cancer agents.
The concept, essence and sources of the penal legislation of the Republic of Kazakhstan
Authors: Рахимбердин Куат Хажумуханович
Published: November 2021

В статье исследуются в контексте переосмысления проблемы понятия, сущности и источников уголовно-исполнительного законодательства Республики Казахстан. Автор считает, что уголовно-исполнительное законодательство Республики Казахстан выступает формой выражения национального уголовно-исполнительного права и средством осуществления государственной политики противодействия рецидивной преступности. В связи с этим эффективность данной политики зависит от состояния уголовно-исполнительного законодательства, его задач, источников, принципов, нормативных конструкций. Гуманизация уголовно-исполнительной политики непосредственно отражается на его развитии. Это развитие должно основываться на новейших достижениях пенитенциарной науки и юридической практики.

The article explores in the context of rethinking the problems of the concept, essence and sources of the penal legislation of the Republic of Kazakhstan. The author believes that the penal legislation of the Republic of Kazakhstan acts as a form of expression of the national penal law and a means of implementing the state policy of combating recidivism. In this regard, the effectiveness of this policy depends on the state of the penal legislation, its tasks, sources, principles, regulatory structures. The humanization of penal policy has a direct impact on its development. This development should be based on the latest achievements of prison science and legal practice.
Circumstances considered when electing preventive measure in the form of custodial placement: the foreign experience
Authors: Симагина Наталья Анатольевна
Published: November 2021

На сегодняшний день в международных документах не дается определения заявленных в заглавии статьи обстоятельств. Само перечисление обстоятельств чаще всего имеет место при рассмотрении условий, позволяющих сделать вывод об отсутствии необходимости заключения лица под стражу в качестве меры пресечения. В связи с этим актуальность данной темы состоит в том, что указанный процесс законодательно не урегулирован в полном объеме. Цель статьи - рассмотреть зарубежный опыт обстоятельств, учитываемых при избрании меры пресечения в виде заключения под стражу на примере таких стран, как США, Великобритания, Германия, Австрия. Реализация поставленной цели была достигнута при помощи общенаучных (диалектический, анализа, синтеза) и частнонаучных (формально-юридический, сравнительно-правовой) методов.

To date, international documents do not define the circumstances considered in the article. And the enumeration of circumstances most often takes place when considering conditions that allow us to conclude that there is no need to detain a person as a preventive measure. In this regard, the relevance of this topic is that this process is not legally regulated in full. The purpose of the article is to consider the foreign experience of the circumstances taken into account when choosing a preventive measure in the form of detention on the example of such countries as the USA, Great Britain, Germany, Austria. Based on an analysis of the characteristics of such circumstances, the author comes to the conclusion that it is rational to establish in the law a provision on the admissibility of the use of imprisonment for suspects (accused) in committing, as a rule, serious and especially grave crimes.
About some features of use of confidential assistance of persons in correctional facilities for women
Authors: Тихомиров Алексей Ильич
Published: November 2021

В статье рассматриваются криминологические, социальные, психологические, социально-психологические и психофизиологические особенности женщин, привлекаемых для решения задач оперативно-розыскной деятельности в исправительных учреждениях, а также возможность использования знаний этих особенностей в оперативно-розыскной деятельности.

The article deals with criminological, social, psychological, socio-psychological and psychophysiological features of women involved in solving the tasks of operational-search activity in correctional institutions, as well as the possibility of using the knowledge of these features in operational-search activity.
Illegal entry into a home as a means of differentiating punishment for theft of narcotic drugs
Authors: Беларева Ольга Александровна
Published: November 2021

В статье рассматриваются вопросы квалификации и связанной с ней наказуемости хищения наркотических средств, совершенного с незаконным проникновением в жилище. В научной литературе и разъяснениях Пленума Верховного суда РФ отсутствуют рекомендации по вопросам юридической оценки таких хищений. Это можно объяснить небольшим количеством таких преступлений. Однако они встречаются, и практику квалификации хищений наркотических средств только по ст. 229 УК РФ без совокупности со ст. 139 УК РФ нельзя признать правильной. Автор выделил две группы хищений наркотических средств, совершенных с незаконным проникновением в жилище, на конкретных примерах рассмотрел встречающиеся в приговорах варианты квалификации. В статье указывается, что на законодательном и правоприменительном уровнях отсутствует уголовно-правовая охрана неприкосновенности жилища в случаях хищения наркотических средств с незаконным проникновением в него. Предложение о дополнении ст. 229 УК РФ квалифицирующим признаком «с незаконным проникновением в жилище» автор расценивает как криминологически необоснованное. Наиболее оптимальным способом отражения повышенной общественной опасности рассматриваемого хищения является квалификация по совокупности преступлений, предусмотренных ст. 229 и ст. 139 УК РФ.

The article deals with the issues of qualification and related punishability of theft of narcotic drugs committed with illegal entry into the home. In the scientific literature and explanations of the Plenum of the Supreme Court of the Russian Federation, there are no recommendations on the legal assessment of such embezzlement. This can be explained by a small number of such crimes. However, they meet and practice the skill of theft of drugs only by Art. 229 of the Criminal Code without conjunction with Art. 139 of the Criminal Code cannot be considered correct. The author identified two groups of theft of narcotic drugs committed with illegal entry into the home, and considered specific examples of the types of qualification found in the sentences. The article states that at the legislative and law enforcement levels, there is no criminal legal protection of the inviolability of the home in cases of theft of narcotic drugs with illegal entry into it. The author regards the proposal to add Art. 229 of the Criminal Code of the Russian Federation as a qualifying feature “with illegal entry into a dwelling” as criminologically unfounded. The most optimal way to reflect the increased public danger of the theft in question is to qualify for a set of crimes under Art. 229 and Art. 139 of the Criminal Code of the Russian Federation.
The attitude of condemned to permission of freedom to punishment as a criterion of their correction
Authors: Киселев Михаил Валентинович , Прохорова Мария Владимировна
Published: November 2021

Статья посвящена исследованию сущности и содержания отношения осужденных к наказанию в виде лишения свободы. Отношение осужденного к наказанию отражает нравственную сущность его личности и характеризует его в период отбывания наказания. С одной стороны, отношение осужденных к наказанию определяется его устойчивостью, так как оно возникает и сохраняется на протяжении всего периода отбывания наказания, а с другой стороны - динамичностью, что соответственно предполагает возможность его изменения. Отношение к наказанию выступает как сложное и многогранное явление, в структуре которого необходимо выделять следующие элементы: осознание вины; переживания, связанные с необходимостью отбытия наказания; осознание необходимости отбыть и неотвратимости наказания. В статье анализируются психологические и социально-психологические факторы, обусловливающие развитие тюремной субкультуры, которая негативно сказывается на формировании правильного восприятия наказания. На основе результатов социологических исследований авторами предлагается классификация осужденных в зависимости от их отношения к наказанию.

The article is devoted to the study of the essence and content of the attitude of convicts to punishment in the form of imprisonment. The convict's attitude to punishment reflects the moral essence of his personality and characterizes him during the period of serving the sentence. On the one hand, the attitude of convicts to punishment is determined by its stability, since it arises and remains throughout the entire period of serving a sentence, and on the other hand, by dynamism, which accordingly suggests the possibility of its change. Attitude to punishment acts as a complex and multifaceted phenomenon, in the structure of which it is necessary to highlight the following elements: guilt awareness; experiences associated with the need to serve a sentence; awareness of the need to serve and the inevitability of punishment. The article analyzes the psychological and socio-psychological factors that determine the development of the prison subculture, which negatively affects the formation of the correct perception of punishment. Based on the results of sociological studies, the authors propose a classification of convicts depending on their attitude to punishment.
Legal status of convicts without isolation from society in the context of international legal standards
Authors: Агабекян Алла Липаритовна
Published: November 2021

Рассматривается проблема определения содержания правового статуса осужденных к наказаниям, не связанным с изоляцией от общества. Анализируется эволюция прав, свобод, законных интересов и обязанностей осужденных, содержащихся в международных стандартах об альтернативах лишению свободы. Предложено с учетом отдельных диспозитивных начал в международных стандартах предусмотреть возможность установления договорных отношений между государством в лице службы пробации и осужденным, которые бы регулировали расходы, связанные с отбыванием наказания. В статье содержится критический анализ положения российского уголовно-исполнительного законодательства о полном запрете подвергать медицинским и иным опытам. Отмечаются недостатки, препятствующие нормальной реализации альтернатив лишению свободы. Автором высказаны суждения относительно возможности включения в Уголовно-исполнительный кодекс Российской Федерации новых прав осужденных без изоляции от общества.

The problem of determining the content of the legal status of persons sentenced to punishments not related to isolation from society is considered. The article analyzes the evolution of rights, freedoms, legitimate interests and obligations of convicts contained in international standards on alternatives to imprisonment. It is proposed, taking into account certain dispositive principles in international standards, to provide for the possibility of establishing a contractual relationship between the state represented by the probation service and the convicts, which would regulate the costs associated with serving the sentence. The article contains a critical analysis of the provision of the russian penal legislation on the complete prohibition to subject to medical and other experiments. There are shortcomings that prevent the normal implementation of alternatives to deprivation of liberty. The author makes judgments about the possibility of including new rights of convicts without isolation from society in the Penal Code of the Russian Federation.
Actual aspects of obtaining information when searching the condemned
Authors: Васюков Виталий Федорович , Кремлев Максим Владимирович
Published: November 2021

В настоящей статье авторы, основываясь на проведенном анализе правоохранительной деятельности розыскных подразделений ФСИН России, указывают на типичные источники исходной и последующей оперативно значимой информации, способствующей установлению места нахождения объекта розыска. На первоначальном этапе розыска предложено дифференцировать лиц, владеющих оперативно значимой информацией о месте нахождения разыскиваемого, на заинтересованных и не заинтересованных в обнаружении разыскиваемого. Приведены способы правомерного воздействия на отдельные категории граждан. Предложены тактические приемы, мотивирующие лиц, изначально не заинтересованных в розыске осужденного, к оперативному сотрудничеству. Обращено внимание на отдельные аспекты тактики проведения оперативного опроса, оперативного наблюдения, наведения справок, прослушивания телефонных переговоров, снятия информации с технических каналов связи. Указаны комбинации оперативно-розыскных мероприятий, реализуемых в условиях активного и пассивного противодействия третьих лиц. Значимым моментом выступает обращения оперативных сотрудников к сети Интернет с целью обнаружения актуальной информации о текущей жизнедеятельности разыскиваемого.

In this article, the authors, based on an analysis of the law enforcement activity of the search departments of the Federal Penitentiary Service of Russia, point to typical sources of initial and subsequent operatively significant information that helps establish the location of the wanted object. At the initial stage of the search, it was proposed to differentiate between persons who possess operatively significant information about the location of the wanted person on those interested and uninterested in finding the wanted person. The methods of lawful impact on certain categories of citizens are given. Tactical techniques are suggested that motivate persons who were not initially interested in tracing a convicted person to operational cooperation. Attention is drawn to certain aspects of the tactics of conducting an operational survey, operational monitoring, making inquiries, listening to telephone conversations, and taking information from technical communication channels. The indicated combinations of operational-search measures implemented in the conditions of active and passive opposition of third parties. A significant moment is the appeal of operational employees to the Internet in order to detect relevant information about the current life of the wanted person.
What do ancient names reveal about identities in the past?
Authors: Albris Sofie Laurine
Published: November 2021

What do ancient names reveal about identities in the past?

ArcNames investigated naming in Iron and Viking Age Scandinavia from a material culture perspective. It aimed to understand the role of names in identity constructions and as markers of status and landholding in place names and runic monuments. The vocabulary in personal names corresponded with iconographic and poetic motifs, and names conveyed messages about status, kinship, affiliations and personal qualities.
EcoCare: sustainable design for absorbent hygiene
Authors: Glathe Stefanie
Published: November 2021

EcoCare: sustainable design for absorbent hygiene

The LIFE EcoCare project explores new sustainable material alternatives for absorbent hygiene products (AHP) such as baby diapers, pantyliners and tampons. The research team looks into renewable and recycled resources, for example, cotton, cellulose, corn, bio-SAP, bio-films, bio PE/PP nonwovens and biobased naphtha, including EU locally-sourced fibres. The applied innovative multilayer absorbent technology considerably reduces the material and volume.