bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Proptosis in a Case of Sphenoid-Orbital Meningioma
Authors: Rahman Md Moshiur , Khan Robert Ahmed , Khan SIM Khairun Nabi , Arifin Mohammad Samsul , Chowdhury Muhtamim
Published: September 2022

Sphenoid-orbital meningiomas (SOMs) are difficult to completely resect because they involve the sphenoid wing, orbit, and cavernous sinus. As the tumor invades the optic canal, SOMs frequently appear with visual deficits. The authors of this case report dealt with the case of a 65-year-old male patient who had right-sided proptosis. We diagnosed the patient, and his MRI revealed of having SOMs. The surgical approach was determined by the tumor’s placement in the orbit and cranial cavity and its connections to the optic canal and optic nerve axis. Surgical excision was used to successfully remove the SOM. The patient maintained a proptosis of less than 4 mm during the follow-up period. The visual acuity, visual field, and ocular fundus were examined during the optical follow-up. SOMs are notoriously difficult to treat surgically. The primary goal of surgery in symptomatic individuals with SOMs is to slow down the tumor’s progression. Longer periods of post-operative observation and follow-up are recommended to observe long-term advantages.
Bang. J Neurosurgery 2022; 11(2): 145-149
Derecho al Debido Proceso en el Régimen Disciplinario Militar de las Fuerzas Armadas Ecuatorianas
Authors: Cabezas-Landa  Limber Javier , García-Erazo Erika Cristina
Published: September 2022

Las ramas militares que conforman las Fuerzas Armadas Ecuatorianas son entidades de suma importancia para que el Estado pueda hacer efectivo el ejercicio de su soberanía frente a otras repúblicas y para crear un margen de seguridad dentro del territorio; bajo este contexto, resulta indispensable que sus acciones tanto externas como internas se encasillen dentro de lo que dispone el ordenamiento jurídico, garantizando así la seguridad jurídica de los particulares a quienes prestan el servicio y de los mismos miembros de las filas militares, más aún en los procedimientos disciplinarios que puedan llevarse a cabo. 
El objetivo del trabajo es analizar la forma en la que el Reglamento de Disciplina Militar aborda procesos sancionatorios relacionándolos con los principios y garantías que componen el derecho al debido proceso y a la defensa desde un enfoque jurídico, doctrinario y jurisprudencial mediante un método cualitativo que permita identificar los aspectos más importantes y que en caso de ser necesario, posibilite la presentación de propuestas de reforma que garanticen los derechos constitucionales de todos los elementos militares.
Estrategias de enseñanza aprendizaje en educación superior: análisis desde la percepción del alumno, escuela profesional de educación, Universidad Nacional de San Antonio de Abad del Cusco – Filial Espinar 2019
Authors: Lavilla-Abarca Francisca , Chalco-Vargas Fredy , Apaza-Apaza Jhon
Published: September 2022

El desarrollo de la presente investigación tuvo como objetivo indagar sobre la percepción de los estudiantes sobre las estrategias de enseñanza aprendizaje en la Escuela Profesional de Educación de la Universidad Nacional San Antonio Abad del Cusco – filial Espinar 2019, para lo cual se recurrió al método hipotético deductivo, un enfoque cuantitativo, de diseño no experimental transeccional descriptivo, para ello se utilizó un muestreo probabilístico aleatorio simple de 89 estudiantes matriculados para el periodo 2019 – II en la escuela profesional de educación de la casa superior señalada. Para el procesamiento y tabulación de los datos recaudados se utilizaron herramientas estadísticas mediante el programa conocido como SPSS v.24. Finalmente el desarrollo de la investigación llego a la conclusión de que se ha logrado indagar sobre la percepción que tienen los estudiantes de la Escuela Profesional de Educación respecto de las estrategias de enseñanza aprendizaje que son aplicadas por los docentes y por ellos en el desarrollo de las sesiones a fin de formarlos como docentes de lo cual se tiene que en ambos aspectos se muestran deficiencias importantes según indican los estudiantes que participaron del cuestionario, lo que tendría incidencias en su proceso de formación como docentes.
Aprendizaje basado en juegos como estrategia didáctica en la carrera de Odontología
Authors: Moscoso-Abad María , García-Herrera Darwin , Álvarez-Lozado María
Published: September 2022

Es muy importante que el estudiante universitario esté bien preparado, con conocimientos, capacidades y destrezas que pueda aplicarlos en su vida profesional, por lo que la instrucción eficiente en la vida universitaria es la base para el mismo, reforzando dichos conocimientos con prácticas y destrezas que refuercen el aprendizaje. En la actualidad se está implementando el juego en el aula de clases, con el fin de mejorar la calidad de educación en el estudiante, además de salir de la clase tradicional, que puede resultar repetitiva y aburrida, disminuyendo el interés y la capacidad de concentración en los alumnos, repercutiendo directamente en el rendimiento y posteriormente vida profesional del estudiando. El presente estudio busca conocer, de qué manera el Aprendizaje Basado en Juegos puede ser utilizado como estrategia didáctica por parte de los docentes universitarios, para mejorar la experiencia educativa del estudiante en el aprendizaje, en alumnos de la carrera de Odontología de la Universidad Católica de Cuenca. Es una investigación que presenta un enfoque mixto, con un alcance descriptivo-exploratorio, en la misma se demuestra la importancia del juego en el proceso de aprendizaje del estudiante, su enfoque es cuantitativo diseñado para tener información importante, basada en la experiencia de los docentes, se desarrollará una aproximación cualitativa, con la formación de un grupo focal que permitirá conocer de cerca los retos que tienen los docentes y si es posible resolverlos.
Evaluación docente, perspectivas de los docentes de la Universidad Católica de Cuenca - La Troncal
Authors: Quinteros-Cortázar Marcos , Cabrera Berrezueta Luis
Published: September 2022

A nivel internacional, la evaluación es considerada como un proceso sistemático que, a través de la obtención de datos, permite comprobar si se han alcanzado los objetivos planteados respecto a un conjunto de estándares; en el caso de la educación, es un tema trivial, sobre todo si se tiene en cuenta que los docentes son evaluados constantemente; aunque a menudo hay fallas metodológicas tanto en el diseño como en el proceso. La mayoría de los gobiernos latinoamericanos han avanzado significativamente en sus propuestas de carrera docente, sin embargo, a pesar de las buenas intenciones, no logran tener un sistema educativo “exitoso”. En el presente trabajo de investigación se pretende determinar las perspectivas que tienen los profesores con respecto al proceso de evaluación docente; teniendo como resultados como aspectos positivos la motivación, pues 9 de cada 10 docentes consideran necesaria la evaluación dentro del desarrollo profesional, pues destacan como una oportunidad para mejorar su desempeño en las aulas de clase. Esta aceptación de forma mayoritaria se ve reflejada al analizar los resultados del proceso de aplicación de los instrumentos evaluativos, en él se aprecia que en promedio más del 90% está de acuerdo tanto en la forma de llevarse a cabo todo el proceso evaluativo (desde la inducción previa, durante la evaluación misma y la socialización de los resultados), así como también sobre lo que se les evalúa (dominio de su asignatura, estrategias de enseñanza aprendizaje e investigación formativa).
Análisis de los conceptos de variable y constante en los estudiantesen del Bachillerato General Unificado del Ecuador
Authors: Merino-Toapanta Andrés Esteban , Cueva-Almeida Mario Edmundo , Sarmiento-Sarmiento Narcisa Marisol , Paredes-Proaño Ana Maribel
Published: September 2022

En este trabajo, se presenta un estudio sobre el concepto que poseen los estudiantes de los términos matemáticos: variable y constante.  Para esto, se aplicó un cuestionario a 494 estudiantes del primer semestre de pregrado de la Pontificia Universidad Católica del Ecuador; el mismo que sirvió para determinar cuáles son las palabras más empleadas por los estudiantes para presentar estos conceptos; además, se analizaron estas definiciones para medir su nivel de formalidad y contextualizar el concepto de acuerdo con tres usos fundamentales: función, expresión algebraica y ecuación. Por otro lado, se revisaron 12 textos de Matemáticas oficiales de Educación General Básica (EGB) y Bachillerato General Unificado (BGU) del Ministerio de Educación del Ecuador, utilizados entre los años 2016 y 2019 para analizar el concepto de variable y determinar el contexto en el cual se emplea.
İslami Hareket Bağlamında Alternatif Müzikal Alanın Oluşumu Üzerine Eleştirel Bir Yaklaşım
Authors: AYDIN BULUT Sümeyye
Published: September 2022

Türkiye’de 1980’li yıllarda şiir, roman, sinema gibi birçok sanat faaliyetinin yanı sıra müzik de İslami hareketin oluşturmayı hedeflediği kamusallığın şekillendiği önemli alanlardan birisi olmuştur. Türkiye’nin modernleşme sürecinde dinin siyasal, toplumsal ve kültürel birçok alanda geri çekilmesi İslami söylem ve kavramlar ekseninde inşa edilen yeni bir müzik pratiği ve düşüncesini ortaya çıkarmıştır. Modernleşmenin ikili anlatılarını devam ettiren bir yapılanma içinde İslami habitusta müzik faaliyetleri de ikili bir yapıyı yansıtmaktadır. Müziğin anlaşılması, tecrübe edilmesi dini ve demonik diyebileceğimiz bir birine zıt iki alanın var olması problemini karşımıza çıkarmakta ve müzik kendi başına daima demonik bir alanın temsili olarak görülmektedir. Bu yaklaşım tarzı müzik ve dini söylem arasında ortaya çıkan karşılıklı etkileşim olanaklarını ve müziğin çoklu anlam üretme boyutunu sınırlayarak tek boyutlu bir yapı kazanmasına neden olmaktadır. Böylece dini söylem, dini alanın otoritesini müziğin üretildiği her aşamada hem yapı hem de faillik biçimlerine yansıtmaktadır. Bu durumun ürettiği önemli sonuçlardan birisi İslami hareketin kamusallığında alternatif müzikal alanın kendini yeniden üretememesi, dinamik yapısını kaybederek tarihin belli bir döneminde üretilen anlamla özdeşleşmesi ve bunun bir sonucu olarak toplumu etkileme gücünü yitirmesidir.
Pengembangan LKS Berbasis Model Planning Monitoring Evaluating (PME) pada Materi Program Linear
Authors: Putri Rafika , Granita Granita
Published: September 2022

Abstrak. Berdasarkan observasi yang dilakukan di SMA PGRI Pekanbaru, ditemukan bahwa pembelajaran matematika hanya menggunakan modul berupa potongan materi dan lembar latihan soal. Dengan adanya pandemi Covid-19, pembelajaran dilaksanakan dari rumah menggunakan google classroom. Terlihat bahwa banyak siswa yang tidak mengumpulkan lembar latihan soalnya. Maka perlu adanya pengembangan bahan ajar berupa Lembar Kerja Siswa (LKS) yang menarik dan membantu meningkatkan hasil belajar siswa dengan belajar secara mandiri. Penelitian ini bertujuan untuk mengembangkan dan menghasilkan LKS matematika berbasis model Planning Monitoring Evaluating (PME) yang memenuhi kriteria valid dan praktis pada materi program linear. Jenis penelitian ini merupakan penelitian pengembangan (Research and Development) dengan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Subjek penelitian ini adalah siswa kelas XI SMA PGRI Pekanbaru, ahli teknologi pendidikan dan ahli materi pembelajaran yang berasal dari dosen, guru mata pelajaran matematika, dan calon doktor pendidikan matematika sebagai validator LKS. Objek penelitian ini adalah LKS berbasis model Planning Monitoring Evaluating (PME) pada materi program linear. Instrumen pengumpulan data berupa angket. Data yang diperoleh kemudian dianalisis dengan teknik analisis data kualitatif dan teknik analisis data kuantitatif terhadap instrumen angket validitas dan praktikalitas. Hasil penelitian menunjukkan bahwa LKS yang dikembangkan dinyatakan sangat valid dan sangat praktis, sehingga LKS berkualitas baik dan dapat digunakan dalam pembelajaran materi program linear.Kata Kunci: LKS, Model Planning Monitoring Evaluating (PME), Program Linear
Analisis Bibliometrik Terhadap Tren Penggunaan ICT Pada Pembelajaran Matematika
Authors: Supinah Roslani , Soebagyo Joko
Published: September 2022

Abstrak. Penggunaan ICT pada pembelajaran matematika dapat membantu siswa untuk lebih mudah memahami pelajaran matematika. Penelitian ini bertujuan untuk mengetahui tren penulisan artikel penggunaan ICT pada pembelajaran matematika, tren artikel yang memiliki jumlah sitasi terbanyak, klasifikasi peringkat jurnal, negara asal jurnal, dan pemetaan  dalam mencari tren publikasi ilmiah internasional dengan pangkalan data Scopus. Metode yang digunakan adalah analisis bibliometrik. Populasi dari penelitian ini adalah 200 artikel hasil penelusuran data menggunakan aplikasi Publish or Perish (PoP) dari tahun 2011-2021, diperoleh 92 artikel sebagai sampel yang sesuai dengan kriteria kata kunci. Data disimpan dalam bentuk Microsoft Excel sebagai bahan pengolahan data dan disimpan dalam bentuk RIS untuk digunakan pada software VOSviewer untuk mendapatkan pemetaan dalam mencari tren publikasi. Tren penulisan artikel tentang penggunaan ICT mengalami kenaikan yang signifikan dari tahun 2017 sampai pada puncaknya di tahun 2019. Analisis pemetaan software VOSViewer memiliki tiga tema terkait penggunaan ICT pada pembelajaran matematika yaitu “memory aid”, “ effectiveness”, “grade”, dan “mathematics education” yang masih jarang diteliti dan menjadi tema keterbaruan dalam penelitian. Tema tersebut dapat menjadi peluang untuk melakukan penelitian selanjutnya.Kata Kunci: bibliometrik, ICT, pembelajaran matematika, publish or perish, vosviewer
SYNTHESIS, X-RAY CRYSTAL STRUCTURE, SPECTROSCOPIC CHARACTERIZATION AND HIRSHFELD SURFACE ANALYSIS OF DICHLORO-BIS(3,5-DIMETHYL-4-AMINO-1H-PYRAZOLE) COBALT(II)
Authors: Davydenko Yuliya , Pavlenko Vadim , Fritsky Igor , Vynohradov Oleksandr
Published: September 2022

The synthesis and characterization of mononuclear Co(II) complex based on 3,5-dimethyl-4-amino-1H-pyrazole are reported. IR and UV/Vis spectroscopy characterization of the complex are described. The synthesis, results of IR, NMR spectroscopy and elemental analysis of 3,5-dimethyl-4-amino-1H-pyrazole are also reported. X-ray analysis of [Co(C5H9N3)2Cl2] complex reveals that the cobalt atom has a tetrahedral coordination environment formed by two nitrogen atoms belonging to the two 3,5-dimethyl-4-amino-1H-pyrazole ligands [Co1–N1 = 2.005(3) and Co1–N5 = 2.006(3)Å] and two chlorine atoms [Co1–Cl2 = 2.2400(11) and Co1–Cl1 2.2863(12) Å]. In the crystal structure the molecules are linked through intermolecular (N–H···N, N–H···Cl) and intramolecular non-classical (С–H···Cl) hydrogen bonds. Hirshfeld surface analysis of the intermolecular contacts reveals that the most important contributions for the crystal packing are from H···H (47.1%) and H···Cl/Cl···H (28.5%) contacts.
Hirigoyen, Marie-France (2021). Narsisistler İktidarda. (A. Gür, Çev.) İstanbul: İletişim Yayınları, 2021.
Authors: GÜRTEKİN Zeynep Büşra
Published: September 2022

2016 yılında Donald Trump’ın ABD başkanlığını kazanmasından sonra Batı’nın kendine dönük bütüncül imajındaki bölünme, rasyonel/irrasyonel birey ve toplum tartışmalarını ön plana çıkardı. Bu bağlamda yapılan birçok tartışma süregelen modern toplum eleştirilerinin tekrar ele alınmasını içerirken bilimin çeşitli alanlarında da bu tartışmaya yönelik çalışmalar çeşitlendi. Bu çalışmalar, bireyin yapısının ve karar alma süreçlerinin hem psikolojik hem sosyolojik olarak incelenmesini, bu doğrultuda Trump’ı ve Trump’ın seçilmesinde etken toplumsal yapıların ele alınmasını gündeme getirdi. Marie-France Hirigoyen’in Les Narcisisse. Ils Ont Pris Le Pouvoir adlı eseri 2021 yılında İletişim Yayınları tarafından Ayşen Gür çevirisiyle okura sunuldu. Narsisistler İktidarda adıyla çevrilen eser bu tartışmalara psikoloji ve sosyolojinin bir aradalığı ile cevap vererek literatürde yerini almaktadır.
Classification of Arabica Coffee Green Beans Using Digital Image Processing Using the K-Nearest Neighbor Method
Authors: Amanina Nurun Najmi , Saraswati Galuh Wilujeng
Published: September 2022

Arabica coffee is the largest commodity produced by farmers in Pagergunung Village, Bulu District, Temanggung Regency. Coffee production in recent years has increased rapidly by 80% with the increasing lifestyle of the Indonesian people marked by the number of coffee shop buildings in various regions, and of course the demand for Arabica coffee has also increased, therefore it must improve the quality or quality of the coffee itself. However, in determining and classifying the quality of coffee beans, errors often occur due to the lack of understanding of the farmers in processing coffee. Based on this, the purpose of this research is to classify using the K- Nearest Neighbor method and feature extraction using the average value of Red-Green-Blue (RGB) color in determining the quality and quality of coffee beans according to grade so that they can get a high selling price. In this study using as many as 150 training image data and 150 testing image data, the results of this classification accuracy are 80% using k=1.
GLCM Based Locally Feature Extraction On Natural Image
Authors: Faisal Edi , Nugroho Agung , Basuki Ruri Suko , Suharnawi Suharnawi
Published: September 2022

GLCM is a feature extraction method that uses statistical analysis using a gray scale. Contrast, correlation, energy and entropy are feature features whose value will be sought as the basis for finding the threshold which can then be used to find the threshold value in image segmentation. In this study, a local-based GLCM method is used where the image that has been made into grayscale will be divided into 16 parts of the same size. Each section will look for the value of its GLCM features, namely Contrast, correlation, energy and entropy. The calculation of these four features will be applied to 16 parts of the grayscale image, which can then be used to find the threshold value. The results of the four features in the calculation with an angle of 0o are the contrast value = 0.0080, correlation = 0.619, energy : 0.00160 and entropy : 0.05591.
Implications From the Meteorological Data Effects on Water Level Fluctuations of the Lake Van (Eastern Anatolia/Türkiye)
Authors: MEYDAN Ayşegül Feray , AKKOL Suna , DOGAN Onur Hakan
Published: September 2022

Lake Van is located in the eastern part of Türkiye and forms the largest soda lake in the world. In this study, we present the relationship between instrumental data which belongs to Lake Van level changes and meteorological parameters by performing a multilevel analysis. The data set consists of monthly average levels of Lake Van and monthly meteorological parameters (temperature, precipitation and wind speed) between 1944-2019 years. Two different multilevel linear models; random intercept, random intercept and slope model were used. Unstructured (UN) covariance structure and Maximum Likelihood (ML) were used for repeated measurements and estimation, respectively. Log-likelihood (ll), Akaike Information Criteria (AIC), Bayesian Information Criteria (BIC) and AIC Corrected (AICC) were used for the selection of the best model. The random intercept and slope model (Model II) is explained as the best model for the lake level changes in this study. Statistical results in this study indicated that the temperature and wind speed are the key parameters controlling the Lake Van water level fluctuations, whereas the precipitation effect is minimal due to the type of precipitation (snowfall). For this reason, temperature, wind speed and also the type of precipitation (snowfall or rain) must be considered for disaster modelling in settlements of Lake Van and similarly closed basin lakes.
ПРИНЦИПИ ОСВІТИ КОНСЕРВАТОРІВ-РЕСТАВРАТОРІВ У СВІТЛІ КОДЕКСІВ ПРОФЕСІЙНОЇ ЕТИКИ
Authors: Tymchenko Теtiana
Published: September 2022

У статті розглянуто проблематику вищої освіти реставраторів. Виявлено ключові моменти формування засад вищої освіти реставраторів, вперше в Україні цитовано праці французького історика й філософа П’єра Лево та інших іноземних авто рів за цією темою. Проаналізовано найважливіший натепер документ – Професійні вказівки Е.С.С.О. – European Confederation of Conservator-Restorers’ Organisations (Європейської конфедерації організацій консерваторів-реставраторів); вперше наведено український переклад його частини, котра присвячена освіті консерваторів-реставраторів. Проведено порівняння основних положень цього документа, присвячених освіті консерваторів-реставраторів, із діяльністю кафедри техніки та реставрації творів мистецтва Національної академії образотворчого мистецтва і архітектури (Київ). Зроблено висновок про необхідність повного перекладу українською мовою документів Е.С.С.О., а також започаткування власного деонтологічного процесу в українській реставрації.
ДО ВИЗНАЧЕННЯ КЛЮЧОВИХ ПОНЯТЬ ТЕОРІЇ СТИЛЮ В АРХІТЕКТУРІ (НА МАТЕРІАЛІ ЕКЛЕКТИКИ КИЄВА ЗЛАМУ ХІХ–ХХ СТОЛІТЬ)
Authors: Berezyuk Taras , Puchkov Andriy
Published: September 2022

Здійснено спробу теоретичного впорядкування понять стилю в архітектурі, на основі прикладів еклектичної архітектури Києва апробовано їхню чинність. З одного боку, встановлено, що запропоновані до розгляду визначення і модель застосування понять стилю в архітектурі можуть бути стійкими виключно на ґрунті еклектично-сецесійної доби, адже метод встановлення її характеру й особливостей здійснювався з орієнтацією на матеріалістичну природу осмислення архітектурної форми конкретно такого стилю. З іншого боку, що не є виключенням, показано: запропоновані поняття можуть бути корисними і для ширшого застосування, що вимагає подальшого опрацювання. У рамках поняття «стиль архітектури» було диференційовано шляхи його опису, на підставі чого запропоновано поняття «стиль доби» та «художній (історичний) стиль в архітектурі». Значення цих понять підтверджено на конкретних прикладах (до розгляду залучено житлові будинки кінця ХІХ – початку ХХ століття за адресами: бульвар Тараса Шевченка, 36; вулиці Володимира Антоновича, 23; Рейтарська, 29; Ярославів Вал, 36; Богдана Хмельницького, 30/10). Поряд із цими поняттями було вказано на способи їхньої ідентифікації, що вимагало впровадження і чіткого визначення понять «художній метод», «творчий метод», зображальність і вира жальність в архітектурі. Розроблено логічні схеми, по-перше, взаємодії між стилем і методом в архітектурі на підставі з’ясування співвідношення стилю доби і творчого методу та художнього стилю і художнього методу, по-друге, щодо еклектичного стилю доби, базованого на співвідношенні художнього методу еклектизму й художнього методу стилізації. Встановлено, що еклектика – це насамперед стиль в архітектурі, який складається із художніх методів еклектизму та стилізації, що в деяких конкретних випадках за певних умов може бути художнім стилем в архітектурі. Попри все, художній стиль в архітектурі не розглядається з оціночної точки зору. Він передбачає лише конкретний результат творчого методу, що може відбутися або не відбутися.
СТИЛІСТИЧНИЙ ДИСКУРС СУЧАСНОГО УРБАНІЗМУ
Authors: Semenenko Anzhelika
Published: September 2022

Нова парадигма сучасного урбанізму – постіндустріальний урбанізм, покликаний до життя цілим спектром соціокультурних проблем, визначених невідповідністю формотворення та організації простору індустріальних міст запитами соціуму з нов ими стандартами життя. У статті досліджується стилістичне втілення новітніх урбаністичних стратегій як матеріалізація низки теоретичних ідей гуманітарних знань і практичних вимо г сучасних мегаполісів.
«ГРОМАДСЬКИЙ ФАНДРЕЙЗИНГ» ОДЕСЬКОГО НАЦІОНАЛЬНОГО ХУДОЖНЬОГО МУЗЕЮ
Authors: Pozhodzhuk Alona , Andres Hanna
Published: September 2022

У статті досліджено процес трансформації класичного музею зі сталими проблемами культурно-мистецьких закладів (незадовільний стан будівлі, недофінансування тощо) у відреставрований сучасний заклад з оновленою матеріально-технічною базою, проведеним ребрендингом та власною реставраційною майстернею, наведені приклади можливих засобів залучення фінансування. Серед джерел надходження громадських коштів увага приділена «Клубу Маразлі», підтримці соціально відповідального бізнесу, краудфандинговим платформам, поодиноким внескам відвідувачів, сувенірній продукції та музейним подіям. Визначено фактори, що впливають на успішність фандрейзингу, зокрема, такі як вивчення своєї аудиторії, формування стратегічного плану розвитку, постійний контакт з відвідувачами та звітування перед громадськістю.
ПОНЯТТЯ АВТЕНТИЧНОСТІ В АРХІТЕКТУРНОМУ ПАМ’ЯТКОЗНАВСТВІ І РЕСТАВРАЦІЇ
Authors: Prybieha Leonid
Published: September 2022

У статті за результатами морфологічного аналізу пам’ятки архіте ктури й осмислення основних складників, зокрема архітектурної форми, матеріальної структури та інших, розкрита пам’яткоохоронна сутність матеріальної субстанції об’єкта культ урної спадщини. На цьому підґрунті визначене поняття автентичності як стан (оцінка) матеріальної субстанції пам’ятки в експертно визначеному хронологічному вимірі починаючи з часу створення, що дає змогу визнавати її документальним свідченням історії й оригінальним т вором мистецтва архітектури.
«ФІЛОСОФІЯ СЕРЦЯ» УКРАЇНСЬКОГО МИСТЕЦТВА ДОВКІЛЛЯ
Authors: Lisova Nataliia
Published: September 2022

Дослідження присвячене аналізові контексту вітчизняного лендарту в системі українського сучасного мистецтва. Вперше, шляхом розгляду ключових філософських течій в Україні, визначено кордоцентричну та антеїстичну складові як основоположні риси творчого пошуку українських художників лендарту.
Asymptomatic sensitization to a cow’s milk protein induces sustained neuroinflammation and behavioral changes with chronic allergen exposure
Authors: Brishti Afrina , Germundson-Hermanson Danielle L. , Smith Nicholas A. , Kearney Angela E. , Warda Yassmine , Nagamoto-Combs Kumi
Published: September 2022

Mouse models of food allergy have contributed to our understanding of various aspects of the disease, including susceptibilities, symptom spectra, cellular mechanisms, and therapeutic approaches. Previously, we used a mouse model of non-anaphylactic cow’s milk allergy (CMA) and investigated sex- and strain-dependent differences in immunological, neurological, and behavioral sequelae. We showed that male C57BL/6J mice sensitized to a bovine whey protein, β-lactoglobulin (BLG; Bos d 5), exhibited anxiety- and depression-like behavior upon acute allergen challenge. Systemic levels of BLG-specific immunoglobulins, cytokines and chemokines were also elevated in the sensitized mice. Furthermore, neuroinflammation and intestinal dysbiosis were evident as the possible causes of the altered behavior. To assess whether frequent allergen exposure influences CMA-associated pathologies over an extended period in this subclinical model, we placed BLG-sensitized mice on a whey protein (WP)-containing or whey-free control (CTL) diet for 3 months. As expected, allergen-specific IgE was significantly elevated in the plasma after completing the 5-week sensitization phase. However, the IgE levels declined in both diet groups after 3 months. In contrast, allergen-specific IgG1 stayed elevated in sensitized mice with the CTL diet, and the WP diet to a lesser extent. Interestingly, BLG-sensitized mice on the WP diet exhibited anxiety-like behavior and a trend toward spatial memory decline compared to the sham or the sensitized mice on the CTL diet. Moreover, increased immunoreactivities for GFAP and Iba1 and elevated levels of CXCL13 and CCL12, the chemokines involved in central leukocyte recruitment and other neurological diseases, were also observed in the brain. We demonstrated that sensitization to the whey protein, particularly with continuous allergen exposure, resulted in persistent neuroinflammation and associated behavioral changes despite lowered allergen-specific immunoglobulin levels. These results suggested that continuous consumption of the offending allergen may lead to adverse consequences in the brain even after desensitization.
Progress in partially degradable titanium-magnesium composites used as biomedical implants
Authors: Wang Jianping , Bao Zhifan , Wu Chenliang , Zhang Song , Wang Ningwei , Wang Qiang , Yi Zhe
Published: September 2022

Titanium-magnesium composites have gained increasing attention as a partially degradable biomaterial recently. The titanium-magnesium composite combines the bioactivity of magnesium and the good mechanical properties of titanium. Here, we discuss the limitations of conventional mechanically alloyed titanium-magnesium alloys for bioimplants, in addition we summarize three suitable methods for the preparation of titanium-magnesium composites for bioimplants by melt: infiltration casting, powder metallurgy and hot rotary swaging, with a description of the advantages and disadvantages of all three methods. The titanium-magnesium composites were comprehensively evaluated in terms of mechanical properties and degradation behavior. The feasibility of titanium-magnesium composites as bio-implants was reviewed. In addition, the possible future development of titanium-magnesium composites was discussed. Thus, this review aims to build a conceptual and practical toolkit for the design of titanium-magnesium composites capable of local biodegradation.
Preventing the spread of COVID-19 through environmental design in Thai community hospitals
Authors: Waroonkun Tanut , Prugsiganont Supuck
Published: September 2022

The unprecedented outbreak of COVID-19 has had a tremendous negative impact on healthcare facilities, especially public hospitals. Thai community hospitals serve as primary care for COVID-19 patients. However, many hospital buildings were constructed in the 1990s and are now becoming outdated. Community hospitals faced many difficulties during the Thailand COVID-19 outbreak. To identify these difficulties this study focused on the physical settings of the community hospital’s outpatient departments (OPD) between 2020 and 2021. Furthermore, the study provided design suggestions for preventing the spread of respiratory infectious diseases. The study used a three-step process of data collection. The first was to observe the physical settings of the OPD buildings of the three hospitals. Secondly, interviews were conducted with thirty healthcare employees: 11 from the first hospital, 11 from the second hospital and 8 from the third hospital. Interviews were transcribed and analyzed using content analysis. Subsequently, the architectural design was produced based on observation and interview analysis. In the third step, the same thirty participants evaluated the architectural design through a focus group. Findings from the interviews led to four themes: 1) factors leading to the accumulation of pathogens, 2) measures for preventing the spread of respiratory diseases, 3) the effect of patient numbers on virus transmission, and 4) suggestions for improving the physical setting of OPDs. The analysis of the four themes led to the preliminary design recommendation, which was evaluated through a focus group, leading to suggestions for the improvement of thirteen areas. The analysis results showed that the participants were satisfied with the architectural design with additional minor recommendations. This study provided originality for the implementation and future development of hospital layout designs that can prevent the spread of COVID-19 throughout Thai community hospitals.
Altered resting-state functional connectivity in hiPSCs-derived neuronal networks from schizophrenia patients
Authors: Puvogel Sofía , Blanchard Kris , Casas Bárbara S. , Miller Robyn L. , Garrido-Jara Delia , Arizabalos Sebastián , Rehen Stevens K. , Sanhueza Magdalena , Palma Verónica
Published: September 2022

Schizophrenia (SZ) is a severe mental disorder that arises from abnormal neurodevelopment, caused by genetic and environmental factors. SZ often involves distortions in reality perception and it is widely associated with alterations in brain connectivity. In the present work, we used Human Induced Pluripotent Stem Cells (hiPSCs)-derived neuronal cultures to study neural communicational dynamics during early development in SZ. We conducted gene and protein expression profiling, calcium imaging recordings, and applied a mathematical model to quantify the dynamism of functional connectivity (FC) in hiPSCs-derived neuronal networks. Along the neurodifferentiation process, SZ networks displayed altered gene expression of the glutamate receptor-related proteins HOMER1 and GRIN1 compared to healthy control (HC) networks, suggesting a possible tendency to develop hyperexcitability. Resting-state FC in neuronal networks derived from HC and SZ patients emerged as a dynamic phenomenon exhibiting connectivity configurations reoccurring in time (hub states). Compared to HC, SZ networks were less thorough in exploring different FC configurations, changed configurations less often, presented a reduced repertoire of hub states and spent longer uninterrupted time intervals in this less diverse universe of hubs. Our results suggest that alterations in the communicational dynamics of SZ emerging neuronal networks might contribute to the previously described brain FC anomalies in SZ patients, by compromising the ability of their neuronal networks for rapid and efficient reorganization through different activity patterns.
Becoming female: Ovarian differentiation from an evolutionary perspective
Authors: Nicol Barbara , Estermann Martin A. , Yao Humphrey H-C , Mellouk Namya
Published: September 2022

Differentiation of the bipotential gonadal primordium into ovaries and testes is a common process among vertebrate species. While vertebrate ovaries eventually share the same functions of producing oocytes and estrogens, ovarian differentiation relies on different morphogenetic, cellular, and molecular cues depending on species. The aim of this review is to highlight the conserved and divergent features of ovarian differentiation through an evolutionary perspective. From teleosts to mammals, each clade or species has a different story to tell. For this purpose, this review focuses on three specific aspects of ovarian differentiation: ovarian morphogenesis, the evolution of the role of estrogens on ovarian differentiation and the molecular pathways involved in granulosa cell determination and maintenance.
An interplay between BRD4 and G9a regulates skeletal myogenesis
Authors: Yang Naidi , Das Dipanwita , Shankar Shilpa Rani , Goy Pierre-Alexis , Guccione Ernesto , Taneja Reshma
Published: September 2022

Histone acetylation and methylation are epigenetic modifications that are dynamically regulated by chromatin modifiers to precisely regulate gene expression. However, the interplay by which histone modifications are synchronized to coordinate cellular differentiation is not fully understood. In this study, we demonstrate a relationship between BRD4, a reader of acetylation marks, and G9a, a writer of methylation marks in the regulation of myogenic differentiation. Using loss- and gain-of-function studies, as well as a pharmacological inhibition of its activity, we examined the mechanism by which BRD4 regulates myogenesis. Transcriptomic analysis using RNA sequencing revealed that a number of myogenic differentiation genes are downregulated in Brd4-depleted cells. Interestingly, some of these genes were upregulated upon G9a knockdown, indicating that BRD4 and G9a play opposing roles in the control of myogenic gene expression. Remarkably, the differentiation defect caused by Brd4 knockdown was rescued by inhibition of G9a methyltransferase activity. These findings demonstrate that the absence of BRD4 results in the upregulation of G9a activity and consequently impaired myogenic differentiation. Collectively, our study identifies an interdependence between BRD4 and G9a for the precise control of transcriptional outputs to regulate myogenesis.
Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations
Authors: Chen Chuck T. , Shao Zhuo , Fu Zhongjie
Published: September 2022

Retina is rich in lipids and dyslipidemia causes retinal dysfunction and eye diseases. In retina, lipids are not only important membrane component in cells and organelles but also fuel substrates for energy production. However, our current knowledge of lipid processing in the retina are very limited. Peroxisomes play a critical role in lipid homeostasis and genetic disorders with peroxisomal dysfunction have different types of ocular complications. In this review, we focus on the role of peroxisomes in lipid metabolism, including degradation and detoxification of very-long-chain fatty acids, branched-chain fatty acids, dicarboxylic acids, reactive oxygen/nitrogen species, glyoxylate, and amino acids, as well as biosynthesis of docosahexaenoic acid, plasmalogen and bile acids. We also discuss the potential contributions of peroxisomal pathways to eye health and summarize the reported cases of ocular symptoms in patients with peroxisomal disorders, corresponding to each disrupted peroxisomal pathway. We also review the cross-talk between peroxisomes and other organelles such as lysosomes, endoplasmic reticulum and mitochondria.
A comparative study of three chemometrics methods combined with excitation–emission matrix fluorescence for quantification of the bioactive compounds aesculin and aesculetin in Cortex Fraxini
Authors: Li Ze Ying , Li Xin Kang , Lin Yuan , Feng Na , Zhang Xiang-Zhi , Li Qing-Lin , Li Bao Qiong
Published: September 2022

Cortex Fraxini is an important traditional Chinese herbal medicine with various medical functions. Aesculin and aesculetin are the main effective components of Cortex Fraxini. The fluorescence signals of the two compounds have a high degree of overlap with each other, making quantitative analysis difficult with conventional analytical methods. In the present study, different chemometrics methods, including lasso regression (LAR), interval partial least squares (iPLS), and multidimensional partial least squares (N-PLS) methods, were employed and combined with excitation–emission matrix (EEM) fluorescence for the purpose of accurate quantification of aesculin and aesculetin in Cortex Fraxini samples. The most satisfactory results were obtained by using the N-PLS method based on the EEM spectra without scatterings, with correlation coefficient of calibration and prediction values higher than 0.9972 and 0.9962, respectively, root mean squared errors for calibration and prediction values lower than 0.0304 and 0.1165, respectively, and recovery values in the range of 83.32%–104.62%. The obtained credible models indicated that the N-PLS method combined with EEM spectra has the advantages of being green, low cost, and accurate and it is a good strategy for the determination of active compounds in complex samples. To further confirm the accuracy of the obtained results, the same samples were analyzed by the recognized ultra-performance liquid chromatography method.
No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study
Authors: Chen Lu , Sun Xingang , Zheng Liangrong
Published: September 2022

Background

Numerous studies have been conducted to investigate the relationship between tea consumption and the risk of cardiovascular diseases (CVD); however, no conclusive results have been achieved. We conducted a Mendelian randomization (MR) study to elucidate the causal associations between tea consumption and several CVD outcomes, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF).

Methods

Independent single-nucleotide polymorphisms (SNPs) genome-wide significantly associated with tea consumption were used as instrumental variables (IVs). Summary statistics for CVD outcomes were obtained from the corresponding genetic consortia and the FinnGen consortium. The inverse-variance weighted (IVW) method was the primary analytical method, and MR estimates from different data sources were combined using fixed-effects meta-analysis. Supplementary MR analyses, including the weighted median, MR-Egger, and the MR pleiotropy residual sum and outlier methods, were conducted to evaluate the robustness of the results. Further MR analyses were repeated by including more genetic variants at a higher P-value threshold.

Results

We found that genetically predicted tea consumption was not causally associated with any CVD outcomes in the IVW method using data from large genetic consortia [CAD: odds ratio (OR) = 1.00, 95% confidence interval (CI), 0.91, 1.10, P = 0.997; MI: OR = 0.98, 95% CI, 0.90, 1.08, P = 0.751; AF: OR = 0.97, 95% CI, 0.92, 1.03, P = 0.350; HF: OR = 0.96, 95% CI, 0.88, 1.05, P = 0.401] or the FinnGen consortium (CAD: OR = 1.06, 95% CI, 0.96, 1.17, P = 0.225; MI: OR = 1.01, 95% CI, 0.89, 1.15, P = 0.882; AF: OR = 1.00, 95% CI, 0.88, 1.14, P = 0.994; HF: OR = 0.96, 95% CI, 0.88, 1.04, P = 0.362). The results were robust and consistent across meta-analysis, supplementary MR analyses, and analyses with more IVs included.

Conclusion

This MR study revealed no causal association between tea consumption and four CVD outcomes, suggesting that tea consumption may not be beneficial for the primary prevention of CVD.
Pregnant outcomes of critically ill pregnant patients with pulmonary hypertension: A multicenter retrospective study
Authors: Zhang Lin , Qie Guoqiang , Yin Xiaoyu , Zhao Hongyan , Zhang Fusen , Wang Tao , Meng Mei , Sha Jing , Chu Yufeng
Published: September 2022

Objective

To identify the pregnancy outcomes and risk factors of critically ill pulmonary hypertension (PH) patients with intensive care unit (ICU) admission.

Methods

The multicenter, retrospective cohort study was performed on 60,306 parturients from January 2013 to December 2018 in China. Diagnosis of PH was based on the estimation of systolic pulmonary arterial pressure (sPAP) via echocardiography. Patients were stratified by sPAP into three groups, mild (30–50 mmHg), moderate (51–70 mmHg), and severe (>70 mmHg). The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of in-hospital death, heart failure, and sustained arrhythmias requiring treatment. The secondary outcome was fetal adverse clinical events (FACE), a composite of fetal/neonatal death, prematurity, small birth weight, and fetal distress.

Results

A total of 181 pregnant patients were enrolled, including 101 patients with mild PH, 31 with moderate PH, and 49 with severe PH. The maternal median age was 32 (27, 35) years and 37% were nulliparous. The MACE occurred in 59 (59/181, 32.6%) women, including in-hospital death in 13 (13/181, 7.2%), heart failure in 53 (53/181, 29.3%), and sustained arrhythmias in 7 (7/181, 3.9%). The incidence of FACE was as high as 66.3% (120/181). Compared with mild and moderate PH patients, patients with severe PH had a significantly higher mortality rate (22.4 vs. 1.51%, P < 0.001) and MACE incidence (51.0 vs. 25.8%, P = 0.001). Although the incidence of FACE in severe PH was slightly higher than that in mild to moderate PH, there was no significant difference (69.4 vs. 65.1%, P = 0.724). PH complicated with left heart disease (OR = 4.365, CI: 1.306–14.591), elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) level (OR = 1.051, CI:1.015–1.088), and sPAP level estimated by echocardiography (OR = 1.021; CI: 1.003–1.040) were independently associated with MACE in multivariable regression (P < 0.05). Increased risk of FACE was noted for PH patients combined with eclampsia/preeclampsia (OR = 6.713; CI: 1.806–24.959).

Conclusion

The incidence of MACE and FACE remained high in critically ill pregnant patients with PH, particularly moderate and severe PH in China. Further studies are warranted to identify subsets of women with PH at lower pregnant risks and seek more effective therapy to improve pregnancy outcomes.
Case report: The impact of percutaneous atrial septal defect closure in pulmonary hypertension with co-existing cor triatriatum sinister and multiple cardiac comorbidities
Authors: Tai I-Hsin , Shyu Tsung-Cheng , Hsieh Kai-Sheng , Chen Ke-Wei , Tsai Wan-Jane , Wang Kuo-Yang
Published: September 2022

Cor triatriatum sinister is a rare congenital anomaly characterized by the left-sided triatrial form of the heart. Diverse theories have been proposed regarding its formation, and the failure of incorporation of the common pulmonary vein into the left atrium (LA) during embryogenesis is the most widely accepted theory. Accordingly, cor triatriatum sinister may be associated with pulmonary venous obstruction and post-capillary pulmonary hypertension in the setting of restricted fenestration. A high proportion of patients with cor triatriatum sinister also have an associated secundum atrial septal defect. Pre-capillary pulmonary hypertension, which is unusual in patients with small atrial septal defects (<2 cm), is probably not as rare as some reports indicate, especially when combined with complex comorbidities. The conventional treatment strategy of atrial septal defect closure in patients with pulmonary hypertension, whether associated with cor triatriatum sinister or co-existing multiple cardiac anomalies, involves simultaneous repair with other cardiac surgical procedures. To the best of our knowledge, there is no reported clinical experience of percutaneous atrial septal defect closure in the literature. Herein, we present the case of an elderly female with pulmonary hypertension and coexisting cor triatriatum sinister, secundum atrial septal defect, and multiple cardiac anomalies. Despite optimal medical therapy, the biventricular failure deteriorated, and clinical stabilization could not be achieved. Transcutaneous atrial septal defect closure was then performed. Subsequent investigations showed an initial improvement (perhaps due to elimination of the left-to-right shunt) from this intervention, but the long-term impact did not appear favorable, likely due to multiple uncorrected cardiac anomalies. To the best of our knowledge, this is the first clinical report showing that partial treatment of combined pre- and post-capillary pulmonary hypertension by eliminating the pre-capillary component may have an initial benefit; thus, total surgical correction should be considered a definite therapeutic strategy unless contraindicated.
Safety of chronic high-dose calcium channel blockers exposure in children with pulmonary arterial hypertension
Authors: Wu Yan , Peng Fu-Hua , Gao Xin , Yan Xin-Xin , Zhang FengWen , Tan Jiang-Shan , Hu Song , Hua Lu
Published: September 2022

Background

Chronic calcium channel blockers (CCBs) are indicated in children with idiopathic/heritable pulmonary arterial hypertension (IPAH/HPAH) and positive response to acute vasodilator challenge. However, minimal safety data are available on the long-term high-dose exposure to CCBs in this population.

Methods

Patients aged 3 months to 18 years who were diagnosed with IPAH/HPAH and treated with CCB in the past 15 years were retrospectively reviewed. The maximum tolerated dose and the long-term safety of high-dose CCBs on the cardiovascular and noncardiovascular systems were assessed.

Results

Thirty-two eligible children were enrolled in the study, with a median age of 9 (6–11) years old. Thirty-one patients were treated with diltiazem after diagnosis. The median maximum tolerated dose was 12.9 (9.8–16.8) mg/kg/day. Children younger than 7 years used higher doses than children in the older age group, 16.4 (10.5–28.5) mg/kg/day vs. 12.7 (6.6–14.4) mg/kg/day, P < 0.05. Patients were followed up for a median period of 6.2 (2.6–10.8) years. One patient died from a traffic accident, and others showed a stable or improved WHO functional class status. Thirteen (40.6%) and 10 (31.3%) patients developed arrhythmias and hypotension. Nine (28.1%) patients had sinus bradycardia, five (21.9%) had first-degree or second-degree type II atrial-ventricular blocks, and two (6.3%) had second-degree type II atrial-ventricular blocks. Most of these arrhythmias were transient and relieved after CCB dose adjustment. The most reported noncardiovascular adverse effect was gingival hyperplasia (13, 40.6%), accompanied by different degrees of dental dysplasia. No liver or kidney dysfunction was reported.

Conclusion

Diltiazem was used in a very high dose for eligible children with IPAH/HPAH. The toxicity of long-term CCB use on the cardiovascular system is mild and controllable. Clinicians should also monitor the noncardiovascular adverse effects associated with drug therapy.