bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Differences of Spring Festival Culture between China and Vietnam
Authors: Toai Doan Ba
Published: June 2024

For a long time, China and Vietnam have always had a deep friendship. The development of Vietnam in etiquette, customs and literature is closely related to the historical origins of China and Vietnam. Especially in the Spring Festival culture, Vietnam has retained many characteristics of China. This paper conducts a differentiated study on the Spring Festival culture of China and Vietnam from the aspects of Spring Festival etiquette, Spring Festival activities, cultural concepts, cultural exchanges, and cultural nature, so as to deepen the understanding of the cultural characteristics of the Spring Festival in China and Vietnam. At the same time, it also explores the social adaptability of the Spring Festival culture in modern China and Vietnam, so that more Vietnamese people can understand the cultural characteristics of China through the differentiated comparison of the Spring Festival culture, and further promote the cultural exchanges between China and Vietnam.
Research on Intelligent Control and Optimization Methods in Power Systems
Authors: Xiao Mingxin
Published: June 2024

As the scale and complexity of power systems continue to expand, traditional control and optimization methods are increasingly unable to meet the needs of modern power systems. Intelligent control and optimization methods, by introducing advanced artificial intelligence technologies, can better address complex issues within power systems. This paper explores the application of intelligent control and optimization methods in power systems, analyzing their basic principles, implementation methods, and practical application cases. The research aims to improve the operational efficiency and stability of power systems, providing theoretical support for the modern management of power systems.
Usefulness, Ease-of-use, and Acceptance towards Generative AI in Language Learning of Non-Language Majors: A TAM-based Study
Authors: Yang Yichen , Sun Hao , Chai Zihan , Jiang Geyu , Estigoy Edison
Published: June 2024

https://ijaers.com/detail/usefulness-ease-of-use-and-acceptance-towards-generative-ai-in-language-learning-of-non-language-majors-a-tam-based-study/
Leveraging Machine Learning for Crop Prediction and Management
Authors: Khan Ahezam Ahewar
Published: June 2024

Abstract: In a world where agricultural resources are limited and environmental sustainability is paramount, the Smart Crop Prediction and Management project emerges as a beacon of innovation for modern farming. This project is designed to revolutionize traditional agricultural practices by combining cutting-edge technology and data-driven insights to ensure the efficient use of resources and maximize crop yields. At its core, this project aims to predict the most suitable crops for cultivation based on a multitude of factors, including soil type, geographic location, weather predictions, and past crop performance. Utilizing advanced machine learning algorithms, the system transforms vast datasets into actionable recommendations, empowering farmers to make informed decisions about crop selection. Beyond predictive insights, the project also offers an intuitive crop management system that assists farmers throughout the entire crop cycle, from planting to harvest. It provides real-time monitoring of environmental conditions such as soil moisture, temperature, and humidity. Additionally, it offers early detection of potential threats, such as pests and diseases, ensuring timely intervention and crop protection. The Smart Crop Prediction and Management project isn't just about technology; it's about transforming agriculture into a smarter, more sustainable, and data-informed industry. By adopting this innovative system, farmers can optimize their resources, increase productivity, and contribute to a greener and more prosperous future.
Fold-Transversal Clifford Gates for Quantum Codes
Authors: Breuckmann Nikolas P. , Burton Simon
Published: June 2024

We generalize the concept of folding from surface codes to CSS codes by considering certain dualities within them. In particular, this gives a general method to implement logical operations in suitable LDPC quantum codes using transversal gates and qubit permutations only.To demonstrate our approach, we specifically consider a [[30, 8, 3]] hyperbolic quantum code called Bring's code. Further, we show that by restricting the logical subspace of Bring's code to four qubits, we can obtain the full Clifford group on that subspace.
Does ROE Moderate the Impact of Temporary Shirkah Funds on SMEs Financing in Indonesia?
Authors: Arisnawati Nur Fani
Published: June 2024

This study investigates the impact of temporary shirkah funds on the financing of Small and Medium Enterprises (SMEs) in Indonesia, using Bank Syariah Indonesia (BSI) as a sample. The Return on Equity (ROE) is utilized as a moderating variable. Employing a quantitative approach, secondary data was collected from BSI’s quarterly reports on the Indonesia Stock Exchange for the period of 2019-2021. The data was analyzed using Moderated Regression Analysis (MRA) with the Eviews 9 application. The results indicate that temporary syirkah funds have a significant partial effect on SMEs financing. However, ROE does not moderate the relationship between temporary syirkah funds and SMEs financing in BSI. These findings provide valuable insights for future researchers to further explore SME financing and highlight the importance of government support for Islamic banks in their efforts to finance SMEs, given the crucial role these enterprises play in the real sector and in bolstering the Indonesian economy. This study contributes to the growing body of literature on Islamic finance and SME financing, offering practical implications for policymakers and Islamic financial institutions.========================================================================================================ABSTRAK – Apakah ROE Memoderasi Pengaruh Dana Syirkah Temporer terhadap Pembiayaan UKM di Indonesia? Penelitian ini mengkaji pengaruh dana syirkah temporer terhadap pembiayaan Usaha] Kecil dan Menengah (UKM) di Indonesia dengan sampel pada Bank Syariah Indonesia (BSI) sementara Return on equity (ROE) dijadikan sebagai variabel moderasi. Menggunakan pendekatan kuantitatif, data penelitian dikumpulkan dari laporan triwulanan BSI di Bursa Efek Indonesia (BEI) untuk periode 2019-2021. Data dianalisis menggunakan Moderated Regression Analysis (MRA) dengan aplikasi Eviews 9. Hasil penelitian menunjukkan bahwa dana syirkah temporer memiliki pengaruh parsial yang signifikan terhadap pembiayaan UKM, tetapi ROE tidak memoderasi hubungan antara dana syirkah temporer dengan pembiayaan UKM di Bank Syariah Indonesia. Temuan ini dapat menjadi dasar bagi peneliti selanjutnya untuk lebih mengeksplorasi pembiayaan UKM dengan fokus urgensi dukungan pemerintah bagi bank syariah dalam pembiayaan UKM, mengingat peran penting yang dimainkan oleh usaha-usaha ini di sektor riil dan dalam mendorong perekonomian Indonesia. Studi ini berkontribusi terhadap pengembangan literatur tentang keuangan syariah dan pembiayaan UKM, memberikan implikasi praktis bagi pembuat kebijakan dan lembaga keuangan syariah.
Indonesian Horizons in Islamic Finance: Navigating Risk, Innovation, and Social Impact
Authors: Ibrahim Azharsyah
Published: June 2024

This edition of "Share: Journal of Islamic Economics and Finance" presents a diverse range of insightful research and findings exploring various aspects of Islamic economics and finance. The studies cover topics such as the innovative Micro Waqf Bank model in Aceh, determinants of risk in Indonesian Islamic banking, Ibn Khaldun's nuanced theory of economic development, the potential of Cash Waqf Linked Deposit (CWLD) in revitalizing Islamic banking, financial performance evaluation of mining companies listed on the Jakarta Islamic Index, redefining Customer Relationship Management (CRM) for the digital age, the influence of Islamic marketing strategies on pre-loved clothing purchases, the nexus between Sharia governance and financial performance in Indonesian Islamic banks, mitigation strategies for Islamic financing risk, the impact of temporary shirkah funds on SME financing, a gravity model analysis of Indonesia's trade role within OIC economies, protection of Hajj and Umrah pilgrims from fraud, the role of fintech lending in expanding Sharia financial inclusion and human development, the mediating role of perceived usefulness in Sharia fintech adoption among Gen Z, the SDG-Islamic banking nexus in major OIC economies, the impact of macroeconomics on Islamic banking and MSME futures during the COVID-19 crisis, and the transition to Sharia-compliant finance in Aceh amidst miscommunication, misperceptions, and resistance. These studies employ various methodologies, including quantitative analysis, qualitative approaches, and mixed methods, to investigate the challenges, opportunities, and innovations within the field of Islamic economics and finance. The findings contribute to a deeper understanding of Islamic economic thought, sustainable development, risk management, financial inclusion, customer relationship management, and the role of Islamic finance in promoting economic growth and social welfare. The studies also offer practical implications and recommendations for policymakers, regulators, Islamic financial institutions, and researchers, paving the way for a more dynamic, inclusive, and sustainable Islamic financial landscape.
Classification of Intensive-less Intensive and Related-Unrelated TasksTasks
Authors: ARSLAN Mustafa Turan , YILDIRIM Esen
Published: June 2024

This study investigates the classification of electrical brain activity during intensive-less intensive and related-unrelated tasks. EEG signals were collected from 20 physically and mentally healthy university students (15 males, 5 females) residing in Adana and Hatay, Turkey, through 14 channels. Continuous Wavelet Transform analysis was applied for feature extraction. Subsequently, subject-dependent and subject-independent classifications were performed using the k-nearest Neighbor algorithm. In subject-dependent classification, the accuracy range for intensive-less intensive tasks varied between 77.6% and 89.8%, while the range for related-unrelated tasks was between 73.2% and 88%. Subject-independent classification yielded an accuracy of 79.2% for intensive-less intensive tasks and 77.5% for related–unrelated tasks.
Technological aspects of manure wastewater treatment
Authors:   Azov Black Sea Engineering Institute – branch of Don State Agrarian University, Golovko Aleksandr N. , Bondarenko Anatoliy M. ,   Azov Black Sea Engineering Institute – branch of Don State Agrarian University
Published: June 2024

Modern challenges of global economy increasingly require focusing on the state of livestock farming in Russia. As one of key areas of raw material resource of food industry, livestock farming, including pig farming, is undergoing significant difficulties in the struggle for environmental friendliness and competitiveness of the industry. The main difficulties arise in the production of by-products such as liquid manure. The processing of this product requires significant costs according to environmental requirements, and there is a need to search for and optimize technologies for its processing. The purpose of the study is to substantiate the optimization of manure wastewater treatment technology. During the research, an option for a technological line for treating manure wastewater with an optimal set of technological equipment is being considered. The last stage of purification is represented by clarification of the working fluid after separation of wastewater in a pressure flotation unit. The problem with using a pressure flotation unit for clarification of manure waste is the low availability of data for calculating its design parameters in accordance with the characteristics of the new clarified product.
Entrelazamientos de juntas directivas y desempeño empresarial
Authors: Meneses Cerón Luis Ángel , Diaz Olaya Juana Patricia , Caicedo Domínguez Yudith Cristina
Published: June 2024

El presente trabajo proyecta estudiar el efecto de la estructura de la junta directiva (Board interlocks) en el desempeño financiero de empresas colombianas que cotizan en Bolsa durante el periodo 2014-2018, desde una perspectiva mixta que vincula la teoría de la agencia, la dependencia de recursos y el gobierno corporativo. Se evalúan 4 factores: los interlocks, los recursos relativos de la firma, el efecto tamaño y la concentración de la propiedad. Metodológicamente, se examinan firmas que cotizan en la bolsa de valores de Colombia. La relación se analizará mediante modelos de regresión en un panel de datos no balanceado. Se espera que los resultados empíricos del estudio sean extremadamente útiles para los inversores que intervienen en los mercados financieros, además de contribuir a la literatura sobre gobierno corporativo y las finanzas corporativas desde la óptica de los mercados emergentes.
El turismo en México y Colombia
Authors: Martínez Jaramillo Hugo Alberto , Castro Molinares Suly Patricia , Barrera Pardo Sergio Nicolás , Otálvaro Marín María Teresa
Published: June 2024

El turismo es considerado como un fenómeno social, cultural y económico que consiste en la acción de viajar a un lugar y retornar de un sitio de manera voluntaria debido a motivos personales, de negocios, o profesionales hasta el lugar de residencia habitual. Este fenómeno ha venido ganando un papel protagónico dentro de la economía de los países en los últimos años, por ello, en el presente documento se realiza una revisión comparativa del impacto en la economía de Colombia y México, a través de indicadores como el PIB, el número de empleos generados y su porcentaje dentro del número total de personas empleadas. La revisión se hace a través de un estudio de tipo documental, realizando una revisión sistemática desde un enfoque cuantitativo de las diferentes fuentes de artículos científicos alojados en bases de datos y documentos expedidos por organismos internacionales, considerados autoridades en el tema del turismo y la economía. Dentro de los resultados arrojados por el estudio se encuentra que para el año 2021 por cada mexicano que visitaba Colombia, 5 colombianos visitan México. A su vez, para el año 2022 el turismo representaba el 8,3% del PIB mexicano y el 4,5% del PIB colombiano. El análisis de este estudio permite estimar proyecciones del crecimiento del turismo en Colombia y México.
Impacto de las escuelas de campo para agricultores en el departamento de Nariño
Authors: Villota Urbano Claudia Dolores , Silva Calpa Alicia Cristina , Cabrera Otálora Martha Isabel
Published: June 2024

Las Escuelas de Campo - ECA, fueron aplicadas como parte del objetivo número tres del proyecto denominado: “Estudio de sistemas de cultivo asociados a los frutales andinos como estrategia innovadora para la reactivación económica de los municipios de Sandoná, Ipiales, la Florida, Arboleda, Providencia y el Peñol del departamento de Nariño”; este estudio está orientado a subsanar problemáticas derivadas del COVID-19 que afectó considerablemente la productividad de los municipios objeto de estudio. Por consiguiente, por medio de la metodología de diálogos de saberes y la metodología participativa fundamentada en la educación no formal para adultos, se desarrollaron las Escuela de Campo, con el objetivo de fortalecer nuevos conocimientos, habilidades y perspectivas mediante la capacitación práctica y teórica a los agricultores de los seis municipios del departamento de Nariño, porque las ECA ofrecen a los agricultores la oportunidad de experimentar nuevas técnicas agrícolas, prácticas sostenibles y enfoques científicos que pueden desafiar sus métodos tradicionales. Los resultados revelaron impactos significativos demostrados por una transformación personal, cambios en los roles, costumbres y tradiciones y un aumento en el desarrollo económico de los hogares, puesto que las ECA tienen implicaciones relevantes tanto en los agricultores como la teoría del aprendizaje transformador y significativo, que se convierten en estrategias y herramientas para una educación agrícola participativa para la transformación, progreso y sostenibilidad rural en Nariño.
Empowering non-governmental organization representatives: Enhancing collaborative and participatory governance through training initiatives
Authors: Bokayev Baurzhan , Utepova Gaziza , Baktiyarova Guldana , Baitassova Ulbossyn
Published: June 2024

This research article explores the impact of training programs on non-governmental organization (NGO) representatives, aiming to foster collaborative and participatory governance within the non-governmental sector. NGOs increasingly influence decision-making and the implementation of social programs through training programs designed for NGO workers, contributing to the creation of a sustainable and active civil society. Encouraging partners to actively share their knowledge and expertise is key to maintaining integration, trust, and equality in decision-making. This approach ensures greater integration, trust, and equality in decision-making. Ultimately, joint management and planning will only improve over time (Calò et al., 2024). The study employed a mixed-methods approach, combining a survey conducted among 225 NGOs with secondary data analysis of education programs designed specifically for NGOs. The findings highlight the crucial role of training initiatives in equipping NGO representatives with the necessary skills, knowledge, and mindset to effectively engage in collaborative decision-making processes and promote inclusive governance practices. Through the analysis of survey responses and examination of education program outcomes, key factors contributing to successful capacity-building efforts are identified, including tailored training content, interactive learning methodologies, and ongoing support mechanisms. The research provides insights into the significance of investing in training programs for NGO representatives and offers practical recommendations for designing effective training initiatives that can enable the development of collaborative and participatory governance within the NGO sector.
Distribution Status of Invasive Alien Species in the Estuarine Wetlands in East and South Coast, Korea
Authors: Chu Yeounsu , Kim Pyoungbeom , Won Minhyeok
Published: June 2024

Based on the results of survey on estuarine ecosystem conducted from 2021 to 2023, this study analyzed the distribution pattern of invasive alien species. A total of six invasive alien species (Micropterus salmoides [M. salmoides], Lepomis macrochirus [L. macrochirus], Lithobates catesbeianus [L. catesbeianus], Trachemys scripta [T. scripta], Pseudemys concinna [P. concinna], and Pseudemys nelsoni [P. nelsoni]) were identified across 118 estuarine wetlands. The survey revealed 960 individuals of M. salmoides, 2,596 individuals of L. macrochirus, 1,088 individuals of L. catesbeianus, and 44 individuals of T. scripta, while 1 individual of P. concinna and P. nelsoni were found. These invasive species were found to be densely distributed in estuarine wetlands in the Haenam and Goheung regions of the southern coast. Furthermore, the distribution density varied depending on the characteristics and locations of the estuarine wetlands. It was observed that the distribution density was higher in closed type than in open type, in riverine than in lacustrine, and in the south coast than in the east coast. Once the basic survey of estuarine wetlands located on the west coast is completed, a clearer understanding of the nationwide distribution characteristics of invasive alien species in estuarine wetlands can be achieved. This information will be crucial for formulating appropriate management strategies tailored to the characteristics of wetlands or coastal areas in the future.
1002-P: The Accuracy and Feasibility of Real-Time Continuous Glucose Monitoring in Noncritically Ill Hospitalized Patients with Type 2 Diabetes
Authors: SIRINVARAVONG SIRINART , SAKJIRAPAPONG CHOOMPUNUJ , PREECHASUK LUKANA , KUNAVISARUT TADA , WANNACHALEE TAWEESAK , THONGTANG NUNTAKORN
Published: June 2024

Introduction: Continued use of the personal continuous glucose monitoring (CGM) device is recommended in people with diabetes who are treated with intensive insulin therapy during hospitalization to achieve better glycemic control and reduce hypoglycemia. However, initiation of the new real-time CGM (rt-CGM) in hospitalized adult patients has not been approved by the US FDA. This study aims to evaluate the accuracy and feasibility of initiating Glunovo i3 rt-CGM in hospitalized patients with type 2 diabetes mellitus who are admitted to the general medical floors.

Methods: The Glunovo i3™ rt-CGM sensor and transmitter were placed on the patient’s abdomen. The medical personnel calibrated the device with capillary blood glucose (CBG). Paired CBG and sensor glucose values were analyzed for accuracy of CGM using mean absolute relative difference (MARD) and Clarke Error Grid Analysis (CEGA).

Results: Twenty-five patients with type 2 diabetes mellitus were enrolled. Mean age was 72.8 ± 11.6 years and 64% were female. Mean HbA1c was 10±3.1%. All patients required insulin during admission. Mean duration of CGM use was 7.7±2.4 days, and the mean calibration was 2.3±0.7 times/day. There were 397 paired CBG and CGM measurements. The overall MARD was 12.2 ± 12.2%. The lowest MARD was observed in the CBG range of more than 180 mg/dL (11.0 ± 11.1%) and on day 9 of sensor wear (6.8 ± 7.1%). The percentages of glucose readings within ±15%/15 mg/dL, ±20%/20 mg/dL, and ±30%/30 mg/dL of CBG values were 72.8%, 82.9%, and 91.7%, respectively. A total of 96.7% of the data points were in zone A and B of CEGA, and none were in zone E. Percent time in range on day 1 was 41.2 ± 26.2 and improved to 48.3 ± 22.3 in the last 72 hours of sensor wear.

Conclusion: Rt-CGM use in non-critically ill hospitalized insulin-treated type 2 diabetes patients demonstrates high accuracy and potentially improves glycemic control.

Disclosure

S. Sirinvaravong: None. C. Sakjirapapong: None. L. Preechasuk: None. T. Kunavisarut: None. T. Wannachalee: None. N. Thongtang: None.

Funding

Specific League Funds, Thailand (R016421005)
1015-P: Acceptability and Impact of a Spanish-Language Diabetes Management Smartphone Application (mySugr PRO) in Hispanic/Latino Adults with Uncontrolled Type 2 Diabetes
Authors: THORSELL ASHLEY A. , BEVIER WENDY C. , CASTORINO KRISTIN N. , KERR DAVID , ULMER BRIAN , REPETTO ENRICO , GONZALEZ KARLA , MELERO LILIANA
Published: June 2024

Hispanic/Latino (H/L) adults are disproportionately affected and have suboptimal control of Type 2 Diabetes (T2DM). We hypothesize that use of a Spanish-language smartphone application with structured blood glucose (BG) monitoring and proactive diabetes coaching (mySugr® PRO) will improve diabetes self-efficacy, weight, and glucose control in H/L adults with uncontrolled T2DM. Spanish-literate H/L adults with non-intensively treated T2DM and HbA1c 7.5-10.0% were enrolled. Subjects were provided with an Accu-Chek® Guide Me glucometer, trained on use of mySugr® PRO, received education on structured BG monitoring (paired testing before and 2hr post-meal), and given access to diabetes coaching. BG metrics, HbA1c, weight, waist circumference, diabetes self-efficacy and distress were measured before and after 12-weeks; acceptability & quality of the app were evaluated after 12 weeks. H/L adults (22) were enrolled, and 11 have completed to date. Subjects achieved significant reductions in HbA1c, weight, and waist circumference when compared to baseline. Diabetes self-efficacy and distress improved non-significantly. MySugr® PRO was well accepted and perceived to be useful by H/L adults with uncontrolled T2DM. Diabetes self-efficacy and distress improved, and the app provided them with motivation and intention to improve BG control.

Disclosure

A.A. Thorsell: None. W.C. Bevier: None. K.N. Castorino: Research Support; Abbott, Dexcom, Inc. Speaker's Bureau; Dexcom, Inc. Research Support; Lilly Diabetes, Medtronic, MannKind Corporation, Insulet Corporation. Consultant; Medscape. D. Kerr: Advisory Panel; Abbott Diagnostics. Consultant; Sanofi, Better Therapeutics, Inc. Stock/Shareholder; Glooko, Inc. B. Ulmer: Employee; Roche Diabetes Care. E. Repetto: Employee; Roche Diabetes Care. K. Gonzalez: None. L. Melero: None.
1018-P: Evaluating Continuous Glucose Monitoring Documents in Electronic Health Records—A Comparative Study of Algorithmic Classification vs. Manual Review
Authors: ZHENG YAGUANG , ITURRATE EDUARDO , LI LEHAN , WU BEI , WYLIE-ROSETT JUDITH , SMALL WILLIAM R. , ZWEIG SUSAN , FLETCHER JASON , MELKUS GAIL D. , CHEN ZHIHAO , JOHNSON STEPHEN B.
Published: June 2024

Introduction & Objective: Clinical use of continuous glucose monitoring (CGM) is increasing collection and storage of CGM-related documents in electronic health records (EHR); however, the standardization of CGM storage is lacking. We aimed to evaluate sensitivity and specificity of CGM Ambulatory Glucose Profile (AGP) classification criteria. This work is crucial to automatically obtain AGP for real-world CGM research.

Methods: We retrieved 12,415 CGM-related documents from the EHR at NYU Langone Health 2012-2022. We randomly chose2244 (18.1%) documents to evaluate AGP classification criteria. Our document classification algorithm: 1) separated multiple-page document into a single-page image; 2) rotated all pages into an upright orientation; 3) applied optical character recognition to the image; 4) tested for the presence of particular keywords in the text. Two experts in using CGM for research and clinical practice conducted an independent manual review of 62 (2.8%) reports. We calculated sensitivity (correct classification of CGM AGP report) and specificity (correct classification of non-CGM report) by comparing the classification algorithm against manual review.

Results: Among 2244 documents, 1040 (46.5%) were classified as CGM AGP reports (43.3% FreeStyle Libre and 56.7% Dexcom), 1170 (52.1%) non-CGM reports (e.g., progress notes, CGM request forms, or physician letters), and 34 (1.5%) uncertain documents. The agreement for the evaluation of the documents between two experts were 98.4%. When comparing the classification result between the algorithm and manual review, the sensitivity and specificity were 95.0% and 91.7%.

Conclusion: Nearly half of CGM-related documents were AGP reports, which are useful for clinical practice and diabetes research; however, the remaining half documents are administrator files. Future work needs to standardize the storage of CGM-related documents in the EHR.

Disclosure

Y. Zheng: None. E. Iturrate: None. L. Li: None. B. Wu: None. J. Wylie-Rosett: None. W.R. Small: None. S. Zweig: None. J. Fletcher: None. G.D. Melkus: None. Z. Chen: None. S.B. Johnson: None.

Funding

New York Regional Center for Diabetes Translation Research (NY-CDTR); Pilot and Feasibility (P&F) award (P30DK111022-08)
1019-P: Continuous Glucose Monitoring in Pediatric Acute Lymphoblastic Leukemia
Authors: COSSEN KRISTINA , MILLER TAMARA P. , DEGROOTE NICHOLAS , STRANGE LIBERTY , STEVENSON JASON , CASTELLINO SHARON M.
Published: June 2024

Introduction & Objective: Children with acute lymphoblastic leukemia/lymphoma (ALL/LLy) may experience significant treatment-related toxicities, graded per National Cancer Institute-prescribed definitions. During induction, development of hyperglycemia can cause significant morbidity, including monitoring, medical management, or prolonged hospitalization. An objective of the pilot study is to evaluate feasibility and efficacy of continuous glucose monitoring system (CGM) in pediatric ALL/LLy patients.

Methods: A prospective study of patients with ALL/LLy aged 1-21 years began on 2/11/2022 and is ongoing at Children’s Healthcare of Atlanta. After consent to a parent study measuring markers of hyperglycemia risk, patients are invited to enroll in a blinded CGM arm. Libre pro was utilized. Demographic and clinical data (family history of diabetes, medications, targeted AEs presence and grade) are obtained via manual chart abstraction. Descriptive statistics were calculated for study variables.

Results: As of December 2023, 53 patients completed induction in the parent study: 30 (57%) male, 35 (66%) White, 13 (35%) Black, and 42 (79%) Non-Hispanic/Latino. Diagnosis age median was 5.1 years (1.3-18.6). All patients experienced hyperglycemia: 41 (77%) grade 1; 12 (23%) grade 2+ (grade 2: n=7, 13%; grade 3: n=5, 9%). Grade 2+ hyperglycemia patients were more like to have a family history of diabetes (7/12, 53% vs. 8/41, 20%, p=0.03). Insulin management was required in grade 3 hyperglycemia. CGM was consented to and worn by 9 patients (17%) with an average CGM active time of 77% (88-92%) and 6 patients had >70% wear time. During induction, 4 (44%) of the CGM arm required, compared to 1 (2%) of the non-CGM arm. CGM utilizers had no skin rash or infection at CGM site.

Conclusion: A pilot study of children with ALL/LLy showed blinded CGM technology worn during induction therapy has reliable results without complications. Additional studies are needed to explore expanded use of CGM in similar patient populations.

Disclosure

K. Cossen: None. T.P. Miller: None. N. DeGroote: None. L. Strange: None. J. Stevenson: None. S.M. Castellino: Advisory Panel; Seagen Inc, Bristol-Myers Squibb Company.

Funding

Emory/CHOA Pediatric Research Alliance (2021-00109546)
1021-P: In Silico Modeling of a Long-Term Implantable Continuous Blood Glucose Monitor—A Joint Investigation by Glucotrack Inc. and TTP
Authors: BUCKLAND JUSTIN R. , TAROTIN ILYA , MEREDITH SOPHIE A. , GOODE PAUL , THROWER JP , TAPSAK MARK A.
Published: June 2024

Introduction & Objective: An in silico model was developed for Glucotrack's implantable Continuous Blood Glucose Monitor (CBGM). Objectives included determining the longevity of the enzyme-based, electrochemical continuous glucose sensor and identifying critical design parameters for its performance.

Methods: COMSOL Multiphysics® was used to develop an in silico model predicated on, and substantiated against, established benchmarks in continuous glucose sensor modeling research. Glucotrack sensor performance and analyte transport properties were determined from in vitro testing. The model used these inputs to simulate Glucotrack CBGM sensor longevity and performance in response to various design parameters.

Results: The Glucotrack CBGM demonstrated a simulated longevity of at least 2.5 years, as determined by the major limiting factor (enduring enzyme activity). The model enabled rapid identification of critical relationships between key sensor design parameters and the cascade of processes that occur within a glucose sensor.

Conclusion: The model provides valuable insights into implantable CBGM sensor longevity. In silico modeling, coupled with sensor properties derived from in vitro testing, is an important tool for designing successful long-term glucose sensors.

Disclosure

J.R. Buckland: Employee; TTP plc. Research Support; Glucotrack. I. Tarotin: Research Support; GlucoTrack, Inc. S.A. Meredith: Research Support; Glucotrack. Employee; TTP Plc. P. Goode: Employee; Glucotrack Inc. J. Thrower: Employee; Glucotrack Inc. M.A. Tapsak: Employee; Glucotrack Inc.
103-OR: Signaling Mechanisms Underlying Islet Compensation in a Novel Mouse Model of ß-Cell Replication Deficiency
Authors: FOSTER HANNAH R. , SDAO SOPHIA , ADAMS MELISSA , BLUM BARAK , MERRINS MATTHEW J.
Published: June 2024

Diabetes is associated with insulin insufficiency arising from a loss of β-cell function and mass. Disinhibited glucagon secretion, arising from the loss of β-cells, is thought to be responsible for as much as half of hyperglycemia in diabetes. An alternative possibility is that increased glucagon release from α-cells is an adaptive mechanism essential to preserving β-cell function in response to the loss of β-cell mass. To study islet compensation in response to β-cell mass deficiency, we used CRISPR to generate a novel strain of β-cell replication deficient (βRD) mice (Cdk1f/f:Ucn3-Cre). We examined in vivo and ex vivo glucagon and insulin secretion in response to β-cell and α-cell stimuli, performed scRNA-seq on isolated islets, and utilized cAMP and Ca2+ biosensors to test the impact of α-cell paracrine signaling on β-cell function. In the setting of reduced β-cell mass, adult βRD mice exhibited glucose intolerance and reduced insulin secretion that was rescued by α-cell engagement with a mixed meal or intraperitoneal alanine. ScRNA-seq revealed rewiring of α-cell metabolic and secretory genes in isolated βRD islets, and glucagon secretion was increased both in vivo and ex vivo. Correspondingly, antagonism of GLP-1 and glucagon receptors resulted in defective glucose-stimulated insulin secretion in βRD islets, which was otherwise equivalent to controls, indicating that α-cell signaling is necessary to preserve β-cell function in the βRD islets. β-cell cAMP was upregulated in β-cells from βRD islets, and Ca2+ oscillations activated at lower levels of glucose than controls, suggesting that β-cell cAMP production is a key mechanism of compensation. Our results suggest that increased glucagon secretion is initially an adaptive compensation for β-cell mass deficiency. Understanding islet reprogramming under physiological and pathophysiological circumstances could accelerate development of novel therapeutics to ameliorate α and β-cell dysfunction in diabetes.

Disclosure

H.R. Foster: None. S. Sdao: None. M. Adams: Employee; Genentech, Inc. B. Blum: None. M.J. Merrins: None.

Funding

National Institutes of Health (RO1DK113103, T32AG000213, R01AG062328, R01DK127637); U.S. Department of Veterans Affairs (I01BX005113); Health Resources and Services Administration (T32HP10010)
1037-P: Telehealth Use among Medicare Beneficiaries with Diabetes—2020–2023
Authors: SHAO YIXUE , WANG YU , ZHOU XILIN , LUMAN ELIZABETH , HOLLIDAY CHRISTOPHER S. , ZHANG PING
Published: June 2024

Introduction & Objectives: Telehealth use increased among Medicare beneficiaries with diabetes during the initial phase of the COVID-19 pandemic. To determine whether these changes have persisted, we examined monthly telehealth use from 01/2020 to 02/2023.

Methods: Using 100% Medicare 2020-2023 claims, we identified beneficiaries with diabetes using International Classification of Diseases codes (E10, E11) and examined their use of telehealth eligible services (TES). We defined telehealth users as beneficiaries who accessed a TES through telehealth. We calculated the monthly percentage of telehealth use (the number of telehealth users divided by the number of TES users) overall and by race/ethnicity, age, sex, rurality, and clinician specialty.

Results: Telehealth use among Medicare beneficiaries with diabetes who used TES increased from ≤10% per month prior to the pandemic to ≥ 40% in March 2020. The percentage gradually decreased with some fluctuations but has stabilized around 27% since March 2022. Although this trend was similar across groups by race/ethnicity, age, sex, and rurality, level of telehealth use varied by race/ethnicity, age, sex, rurality, and clinician specialty (Figure).

Conclusions: Telehealth use has stabilized at more than twice the pre-COVID pandemic level, implying that telehealth has been integrated as a part of routine diabetes care in older U.S. adults.

Disclosure

Y. Shao: Employee; Biogen. Y. Wang: None. X. Zhou: None. E. Luman: None. C.S. Holliday: None. P. Zhang: None.
1053-P: Enhancing Accessibility—Assessing the Impact of Expanded CGM Coverage on CGM Adoption
Authors: ZENG ALISON , BELTRAN ALAN , BELL TREVOR , WOOD RICHARD
Published: June 2024

In April 2023, the Center for Medicare and Medicaid Services (CMS) expanded continuous glucose monitoring (CGM) coverage to people with diabetes (PWD) on Medicare and basal insulin only. This study examines the impact of these guidelines on CGM accessibility.

From May-Oct. 2023, 177 non-CGM-using PWD on Medicare and basal insulin only, 270 primary care physicians (PCPs), and 187 endocrinologists were surveyed on their awareness of CMS’ expanded coverage. Physicians also reported the impact of the new guidelines on prescribing behavior. CGM usage among PWD was tracked every three months from Sep. 2022 - Sep. 2023.

While most endocrinologists were aware of the new guidelines (78%), awareness showed room for improvement among PWD (31%) and PCPs (44%). Among those aware, 76% of endocrinologists and 64% of PCPs reported increasing the number CGM prescriptions written due to the guideline change. Indeed, since April 2023, CGM usage has increased significantly among PWD on Medicare and basal insulin only (p<.05), rising from 15% in Mar. 2023 to 24% in Sep. 2023 (Fig. 1). By contrast, CGM usage remained stagnant around 15% from Sep. 2022 to Mar. 2023.

The research underscores the notable impact of CMS’ expanded CGM coverage in enhancing access for Medicare recipients on basal insulin only. To promote wider CGM adoption, increasing knowledge of the guidelines among PWD and PCPs, where awareness is particularly low, may be beneficial.

Disclosure

A. Zeng: Employee; dQ&A. Research Support; Abbott, Dexcom, Inc., Eli Lilly and Company, diaTribe, Insulet Corporation, Medtronic, Roche Diabetes Care, Tandem Diabetes Care, Inc., Ypsomed AG, Teladoc Health. A. Beltran: Research Support; Abbott, Dexcom, Inc., Eli Lilly and Company, diaTribe, Insulet Corporation, Medtronic, Roche Diabetes Care, Tandem Diabetes Care, Inc., Ypsomed AG, Teladoc Health. T. Bell: Research Support; Abbott, Dexcom, Inc., Eli Lilly and Company, diaTribe, Insulet Corporation, Medtronic, Roche Diabetes Care, Tandem Diabetes Care, Inc., Ypsomed AG, Teladoc Health. R. Wood: Research Support; Abbott, Dexcom, Inc., Eli Lilly and Company, diaTribe, Insulet Corporation, Medtronic, Roche Diabetes Care, Tandem Diabetes Care, Inc., Ypsomed AG, Teladoc Health.
106-OR: Semaglutide Reduces Tumor Burden in the GAN Diet-Induced Obese and Biopsy-Confirmed Mouse Model of MASH with Advanced Fibrosis and HCC
Authors: FEIGH MICHAEL , TOZZI MARCO , HANSEN HENRIK H.
Published: June 2024

Introduction & Objective: Metabolic dysfunction-associated steatohepatitis (MASH) ncreases the risk for the development of hepatocellular carcinoma (HCC). The present study aimed to evaluate the efficacy of semaglutide, a glucagon-like-receptor (GLP1R) agonist, on disease progression in the translational GAN diet-induced obese (DIO) and biopsy-confirmed mouse model of MASH with advanced fibrosis and HCC.

Methods: Male C57BL/6J mice were fed the GAN diet high in fat, fructose, and cholesterol for 54 weeks (DIO-MASH-HCC mice) prior to treatment intervention. Only mice with liver biopsy-confirmed NASH and advanced fibrosis were included and stratified into study groups. DIO-MASH-HCC mice (n=15-16 per group) received vehicle or semaglutide (30 nmol/kg) once daily for 14 weeks. Untreated DIO-NASH-HCC mice (n=10) were terminated at baseline. Endpoints included within-subject change in nonalcoholic fatty liver disease activity score (NAS), fibrosis stage, quantitative histology, tumor classification and macroscopic tumor count/diameter.

Results: DIO-MASH-HCC mice demonstrated progressive liver tumor burden over the 14-week study period. Tumors showed consistent architectural, cytologic and molecular features of poor prognostic HCC. Semaglutide promoted ≥2-point improvement in NAS, supported by beneficial changes in quantitative histological markers of steatosis and inflammation. While not improving fibrosis, semaglutide substantial reduced tumor numbers, tumor size and histological markers of proliferation (Ki67) and progenitor cell activation (CK19).

Conclusion: Consistent with a recent clinical trial, semaglutide improves MASH while not promoting fibrosis regression in GAN DIO-MASH-HCC mice. Notably, semaglutide markedly lowers HCC burden in the model. Collectively, our data highlights the suitability of GAN DIO-MASH-HCC mice for profiling novel drug therapies targeting MASH-driven HCC.

Disclosure

M. Feigh: Employee; Gubra. M. Tozzi: None. H.H. Hansen: Employee; Gubra.
1060-P: MOMs—Improved Glycemic Control and Diabetes Self-Management for Underserved Pregnant Patients
Authors: SCHELLINGER MEGAN M. , BRITT JESSICA , PASKO DANIEL N. , KEISER SHARON , WEBER SANDRA L. , WHITE HANNAH , ODOM JESSICA , STANCIL MICHELLE D. , SCHULT PAMELA L. , HUNT KATHRYN , FIOCCHI CASEY J. , FINCHER KATHLEEN , CART COURTNEY U. , KELLY ALEXIS , LONDONO DAVID , PEREZ-CANO LINDA , FU DONGXU , LEYVA MISTI J. , LYONS TIMOTHY
Published: June 2024

Background: Management of Maternal Diabetes (MOMs) program provides comprehensive, single-site team care for pregnant patients who are for medically-complex.

Objective: To determine whether MOMs improves glycemic control through specialized care and patient engagement in diabetes self-management (DSMES). Methods: General linear models compared longitudinal A1c and time in range (TIR) to pre-enrollment baseline values for patients delivering June 2020 through March 2023. Surveys were conducted on patient satisfaction, diabetes self-management.

Results: Among 482 patients, 26% were Black, 30% Hispanic, 39% White, 5% Other. For preferred language, 27% cited Spanish. Insurance included 54% Medicaid and 31% Uninsured with Medicaid only for delivery. At baseline, 44% were obese and 28% morbidly obese. Diabetes type comprised 9% Type 1, 35% Type 2, 45% Gestational-A2, 10% Other. Type 1 patients had A1c decrease (p < 0.01) across all trimesters. Type 2 patients had A1c decrease (p < 0.01) in the 2nd and 3rd trimester. Patients using CGMs increased (p = 0.01) TIR from 64% to 77% to 81% across trimesters. Patient surveys showed 93% were very satisfied/satisfied with the availability of multiple providers and services at a single visit; 91% strongly agreed/agreed that MOMs helped them develop healthier lifestyles.

Conclusion: MOMs improved glycemic control and demonstrated a high degree of patient engagement.

Disclosure

M.M. Schellinger: None. J. Britt: None. D.N. Pasko: None. S. Keiser: None. S.L. Weber: None. H. White: None. J. Odom: None. M.D. Stancil: None. P.L. Schult: None. K. Hunt: None. C.J. Fiocchi: None. K. Fincher: None. C.U. Cart: None. A. Kelly: None. D. Londono: None. L. Perez-Cano: None. D. Fu: None. M.J. Leyva: None. T. Lyons: None.

Funding

BlueCross BlueShield of South Carolina Foundation, Diabetes Free SC (2020-09)
1091-P: Decreasing DKA Admissions in High-Risk Youth Using Wrap-Around Services
Authors: IGHALO FULFILLED , RAKHRA PAVANDEEP , BUTLER REBECCA , MARTINEZ AMELIA L. , CRAVEN MEGHAN , DEI-TUTU SELORM A.
Published: June 2024

Background: Recurrent DKA is a major cause of morbidity in children with T1D. In January 2022, we developed a quality initiative to reduce DKA hospitalizations by providing extra support via wrap around services to children at highest risk of DKA. Secondary aims included increased clinic visits, increased technology use and decreased HbA1c.

Methods: Between January and June 2022, patients > 2 years from diagnosis with RI-DKA scores > 9 were identified and provided with wrap around services by a social worker and nurse. Services included a 2-week post DKA follow up and monthly phone calls to facilitate diabetes education, prescription management and psychosocial care. The team also provided appointment reminders, facilitated transportation to clinic and provided psychosocial support during visit. Quarterly DKA admissions as well as secondary measures were compared to baseline utilizing QI methodology.

Results: 24 patients participated in the initial cohort. There was a decrease from 9 DKA admissions per quarter to 3. There was a notable increase in technology use from 62% to 88%, an increase in clinic visits per quarter from 15 to 19, a decrease in average HbA1c from 13.6% to 12.3% and a decrease in RI-DKA from 9.4 to 8.0.

Conclusions: Targeted wrap around services achieved a decrease DKA admissions in the high-risk cohort. Further longitudinal data is needed to determine if change is sustained.

Keywords: Type 1 Diabetes, DKA, High Risk

Disclosure

F. Ighalo: None. P. Rakhra: None. R. Butler: None. A.L. Martinez: None. M. Craven: None. S.A. Dei-Tutu: None.
1100-P: Impact of Best Practice Advisories (BPA) on Therapeutic Inertia of Glycemic Management in Hospitalized Patients
Authors: LINN AUNG NAY , LAPE MEGAN E. , WIN KHAING , KHINE HNINN E. , DUENAS LIZETH , NI HNIN AYE NWE , D'ACCURZIO ALBERT D.
Published: June 2024

Despite increased mortality and morbidity in hospitalized patients with poor glycemic control, therapeutic inertia (TI) exists among them. Best Practice Advisories (BPA) for hospitalized patients with hyperglycemia (BG > 250) or hypoglycemia (BG < 70) were implemented in 2022 in our institution to alert providers and prompt them to act accordingly. In this pilot study, we aim to find out if BPA implementation had an impact on TI and glycemic control. The study involved a non-random sample of patients with diabetes (Inclusion criteria in demographic table) admitted during June 2021 (n = 390) and June 2023 (n=470). Data analysis was performed using SPSS 25. Results showed TI (both rates of intensification and de-intensification) reduced after BPA implementation. And hyperglycemia and hypoglycemia rates also improved.

Disclosure

N. Aung: None. M.E. Lape: None. K. Win: None. H.E. Khine: None. L. Duenas: None. N. Aye: None. A.D. D'Accurzio: None.
1115-P: Differences in Clinical Outcomes by Sociodemographic Characteristics in Adults with Diabetes Receiving Care at a Federally Qualified Health Center
Authors: SAN DIEGO EMILY ROSE N. , VINCENT LAUREN , ORENDAIN NATALIA , SPIERLING BAGSIC SAMANTHA R. , GORDON CHRIS , PHILIS-TSIMIKAS ATHENA
Published: June 2024

Introduction: Racial and ethnic minority and socioeconomically disadvantaged populations are disproportionately burdened by type 2 diabetes (T2D). Federally Qualified Health Centers (FQHCs) provide health services to over 30 million medically underserved populations, with 63% racial and ethnic minorities and 90% at/below the federal poverty threshold.

Objective: Examine data from 35,092 adults with diabetes receiving care from an FQHC offering Diabetes Specialty Care services in San Diego, CA between 2017-2022.

Methods: Linear regression models examined clinical outcomes while controlling for sociodemographic characteristics (age, sex, race, education) and whether an endocrinologist was part of the care team.

Results: Patients were on average 60±13.1 years old, and 51% were women, 54% were Hispanic/Latino, 57% had ≤ high school education, and 7% were seen by an endocrinologist. Mean A1C was 7.9%±2.0 and systolic blood pressure (BP) was 114 mmHg±45. A1C was lower among older patients (β = -0.03, p < .0001), females (β =-0.26, p < .0001), and individuals with a college (β = -0.14, p = .001) or postgraduate (β = -0.40, p < .0001) degree. A1C was higher among patients identifying as Black (β = 0.21, p < .0001), Native American (β = 0.45, p = .011), Pacific Islander (β = 0.46, p = .0001), and Hispanic (β = 0.45, p < .0001) compared to White. BP was lower among females (β = -4.26, p < .0001) and higher among older patients (β = 0.40, p < .0001) and those identifying as Black (β = 6.94, p < .0001), Asian (β = 4.63, p < .001), and Pacific Islander (β = 6.93, p = 0.013) compared to White. While not significant, BP was lower in individuals with higher education compared to those with lower education.

Conclusion: Poorer clinical outcomes were observed in racial and ethnic minorities and individuals with lower education. Targeted strategies for different populations are needed to address disparities in groups that are disproportionately burdened by diabetes.

Disclosure

E.N. San Diego: None. L. Vincent: None. N. Orendain: None. S.R. Spierling Bagsic: None. C. Gordon: None. A. Philis-Tsimikas: Advisory Panel; Dexcom, Inc., Lilly Diabetes, Novo Nordisk, Sanofi, Medtronic, Bayer Inc.

Funding

National Institutes of Health (K12 TR004410); National Institutes of Health (KL2 TR001112)