bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Impact of Gender Bias Among Medical Trainees
Authors: Terry Danielle L. , Terry Christopher P. , Trabold Allison , Nanda Michelle A.
Published: January 2024

Introduction: Research has suggested that health care providers are not immune to implicit and explicit gender bias among their own colleagues and in the treatment of patients. To date, limited research examines gender bias in trainees and how that bias might intersect with patient care. Our study focused on gendered expectations, perceived competence of medical providers, and perceived acceptability of patients who advocate for themselves.
Methods: We used a 2x2x2x2 mixed design to examine the impact of participant gender, type of physical exam (vaginal vs elbow), trainee status, and gender of vignette physician. Participants read and responded to vignettes depicting various standardized clinical scenarios. The complete sample included 342 participants from a rural medical teaching hospital and a private liberal arts college in the same geographic region.
Results: Findings suggested a significant interaction between physicality and gender of the participant on perceived competence.
Conclusions: Although males and females had similar ratings of competence on an exam with low physicality (elbow), the data suggested that males did not recognize how errors during clinical practice may impact a hypothetical female patient. Future research might examine interventions that aim to increase awareness of gender bias among medical trainees and to explore whether interventions might improve patient care and perceptions of competence following identified errors.
Gearing Up: Accelerating Your CV to Promotion and Tenure
Authors: Campbell Kendall M. , Rodríguez José E.
Published: January 2024

The curriculum vitae (CV) is an important document for a faculty member and is one of the first documents reviewed by peers or evaluators when a faculty member is being considered for promotion. It catalogs the training history, accomplishments, awards, and productivity of a faculty member over time. Prior work has demonstrated how the CV should be organized and what content should be included. However, no contributions to the literature have discussed how reviewers and other academic leaders view CVs, how to structure CV entries to promote career advancement, and how CVs can become useful or limiting for faculty, regardless of whether a faculty member is actively going through the promotion process. We discuss how the CV can be seen by evaluators and concerns that can cause the CV to decelerate. We then make recommendations on how the CV can accelerate a faculty member toward academic career advancement and promotion.
The Ideal оf Psychosynthesis and Metamorphosis оf Gender in A.K. Gorsky’s Philosophical and Artistic Practice
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Gacheva Anastasya G.
Published: January 2024

The article presents the views on the “masculine” and the “feminine” and the prospects of gender metamorphosis in the works of poet, aesthetician, philosopher A.K. Gorsky (1886–1943). Relying on Plato’s myth of the androgynes, on the idea of transfiguration declared in Christianity and Gnosticism, Gorsky asserts the bisexual nature of any personality seeking to overcome incompleteness, fragmentation through erotic striving and identification with the other sex, to gain integrity, which for Gorsky is equivalent to immortality, the transformed status of a person. While considering male (ejaculatory-pointwise, functioning on the principle of support) and female (cloud magnetic, developing according to the mirror principle of identification) types of eroticism, he deems the latter to be the most productive, associating with it the psychophysiology of the creative act. Reinterpreting and transforming the achievements of psychoanalytic theory, Gorsky combines them with the concept of transformed Eros, which developed in Russian religious philosophy (N. Fedorov, Vl. Solovyov), and puts forward the ideal of resurrection eroticism, while finding its origins in the works of A. Pushkin, A.K. Tolstoy, Russian Symbolists. The poetic experiments of A.K. Gorsky, revealing the peculiarities of his perception of the “male” and the “female”, his metaphysics of girlhood and motherhood, and artistically embodying the theme of the metamorphosis of love, are considered.
The resolution of quadratic inequality problems in mathematics: Discrepancies between thought and action
Authors: Surya Sari Faradiba  , Alifiani  , Nurul Akmal Md Nasir
Published: January 2024

This research explores the intricate relationship between students' cognitive processes and problem-solving approaches, explicitly focusing on misconceptions in solving quadratic inequalities. This study was conducted among 179 undergraduates in a mathematics education program in Malang, East Java, Indonesia; this mixed-method concurrent explanatory sequential design research employed the DISC questionnaire and quadratic inequality assignments. The DISC questionnaire categorized respondents into Dominance, Influence, Steadiness, and Conscientiousness. Data were generated from these pre-service teacher responses to the questionnaire, task assignment, and follow-up interviews to solicit information. Purposive sampling facilitated in-depth interviews, providing nuanced insights into the interplay between personality types and mathematical misconceptions. The quantitative data analysis results show a significant association between personality type and the type of error experienced by students when completing an open-ended task about quadratic inequalities X2(12) = 26.836, p = 0.008, V = 0.224. Meanwhile, qualitative data analysis findings reveal patterns associating personality types with specific misconceptions. Dominant traits are linked to theoretical misconceptions, while Influence and Conscientiousness traits correspond to conceptual misconceptions. Additionally, Steady traits are associated with classification misconceptions. This study contributes novel perspectives to mathematics education by exploring the influence of personality on mathematical cognition. The aim is to inform tailored teaching strategies for optimized learning outcomes, addressing persistent barriers posed by misconceptions in quadratic inequalities.
Description of Writing Exposition Text Using the Discovery Learning Model Assisted with Media Canva
Authors: Azzahra Iis Siti Salamah , Yunisya Zyan Azhari
Published: January 2024

This study explains the results of students' writing in writing exposition texts. The learning outcomes of these students were divided into two tests as consideration for using the discovery learning model using Canva media, in the first test students carried out learning without using the learning model using Canva media while in the second test students carried out learning using the discovery learning model using Canva media. . This study uses a qualitative descriptive method to show the value of students before and after using the discovery learning model using Canva media. The role of Canva media in learning to write exposition texts is to guide and provoke students to better understand material and use digital media to make learning easier and more efficient. The subjects in this study were 15 class VIII A students at SMP Negeri 3 Cimahi. Acquisition of scores analyzed include the total score of students, the average score of students, analysis of the lowest, middle and highest scores. This study shows the effectiveness of learning to write exposition texts using the discovery learning model using Canva media by obtaining a fairly good average score of 78.5 analysis of lowest, middle and highest scores. This study shows the effectiveness of learning to write exposition texts using the discovery learning model using Canva media by obtaining a fairly good average score of 78.5 analysis of lowest, middle and highest scores. This study shows the effectiveness of learning to write exposition texts using the discovery learning model using Canva media by obtaining a fairly good average score of 78.5.
The governance involvement in the relationship between earnings management and surplus free cash flow
Authors: Aljaloudy Nisreen , Mowafi Omar , AlKhalialeh Mahmoud
Published: January 2024

The purpose of this study is to examine empirically the association between surplus free cash flow (SFCF) and earnings management (EM), and the moderating effect of governance on this relationship. The study used a sample of non-financial companies listed on the Amman Stock Exchange (ASE) over the ten-year period (2011–2020) with all the information necessary to estimate the study variables. The modified Jones (1991) model is used to estimate discretionary accruals, a widely used proxy for earnings management. Based on the regression analysis of the related panel data collected, the study’s findings indicate that SFCF is positively associated with EM activities. This result is consistent with most prior related study’s findings (Nouri & Gilaninia, 2017; Rahmawati, 2020) and suggests that when growth opportunities are limited, the free cash flow induces management to involve in upward management practices. Additionally, results indicate a significant negative impact of the interaction variable SFCF*AQ (audit quality) on EM, suggesting that, in an SFCF situation, AQ reduces manager’s tendency to involve in upward EM practices. The study’s results are likely to be useful for accounting researchers, local governmental bodies, and policymakers who are concern with the impact of EM practices on the quality of earnings.
Rethinking the use of social blogs for corporate reputation management in emerging markets post COVID-19
Authors: Moyo Tabani , Gerwel Proches Cecile , Mutambara Emmanuel , Singh Upasana Gitanjali
Published: January 2024

The study aimed to ascertain how social blogging usage shaped social capital in the new strategy for corporate reputation management, particularly in the wake of the COVID-19 pandemic in Zimbabwe’s telecoms sector. This was dictated by the more general goal of learning how the telecoms sector reacted to the transition from conventional to modern corporate reputation strategies driven by social capital in the era of social blogs. The study positions Twitter between the traditional corporate reputation guides (top-level managers, operation managers, general employees, and customers) and the contemporary methods (boundary theory, social cognitive, social blogs, and social exchange) (Yang, 2020; Mhlophe & Chinjova, 2022; Moyo et al., 2022). A mixed-method approach was employed in the study. The results show that social blogs, specifically Twitter, Facebook, and YouTube, have a direct impact on the management of positive corporate reputation in the telecommunications industry as they contribute to the social capital of the organisation leading to the contemporary management of reputation, which is critical in building organisational resilience post-pandemic. This led to the development of an adapted framework that the industry and practitioners can adopt post the COVID-19 pandemic in emerging markets like Zimbabwe.
Muhammad Amin Al-Shinqiti and the Idea of Economic Equity in the Qur’an
Authors: Anjani I'anatul Maula  , Fejrian Yazdajird Iwanebel
Published: January 2024

This paper delves into the exploration of economic principles within Qur’anic exegesis. The focus centers on the elucidation of economic equity by, Muhammad Amin al-Shinqiti, as expounded in his tafsir “Adwa’ al-Bayan fī Idah al-Qur’an bi al-Qur’an.” A key emphasis is placed on al-Shinqiti’s comprehensive analysis of economic equity within Surah al-Hasyr [59]: 7. Additionally, al-Shinqiti contextualizes the verse to argue that the booty (al-fay’), as mentioned in the verse, should be reclaimed and channeled into state revenues. Employing Hassan Hanafi’s social hermeneutics framework, this article draws the conclusion that al-Shinqiti critically evaluates both capitalist and socialist economic theories. Al-Shinqiti, through his interpretation, asserts that the fundamental essence of the verse is the eradication of favoritism, thus propelling the attainment of economic equity. Al-Shinqiti distinguishes economic equality from economic equity, contending that the former is an unattainable objective. Furthermore, he advocates for an Islamic economic system characterized by a limited free economy, impartial distribution of state resources, and a focus on the comprehensive welfare of society. This exploration sheds light on Al-Shinqiti’s nuanced perspective on economic principles and provides valuable insights into the Islamic economic framework.
Możliwości poprawy produktywności czynników wytwórczych w gospodarstwach rodzinnych
Authors: Kierepka Maria
Published: January 2024

Wykorzystując mechanizm substytucji wskazano sposób poprawy produktywności czynników wytwórczych w gospodarstwach rodzinnych. Dla wyjaśnienia celu badawczego rozważano problem kształtowania efektywności technik wytwarzania określonych przez czynnik pracy i nakładów materialnych przy średniej powierzchni użytków rolnych i przeciętnym poziomie produkcji globalnej. Zróżnicowanie technik odzwierciedlono za pomoc ą równań izokwant, następnie obliczono ich koszty oraz dokonano oceny efektywności. Poprawa produktywności czynników produkcji może być osiągnięta w ramach środków, jakimi dysponują producenci, dzięki zmianom w poziomie i strukturze nakładów czynników określających daną technikę wytwarzania. Zamiana technik z pracochłonnych na kapitałochłonne spowodowała ponad 3-krotny wzrost wydajności pracy w gospodarstwach lubelskich, natomiast w wielkopolskich wzrost ten był prawie 6-krotny.
Paradygmaty dla współczesnego rolnictwa – protekcjonizm kontra liberalizm
Authors: Zawojska Aldona
Published: January 2024

Artykuł opisuje cztery współczesne paradygmaty rolnictwa: zależności, konkurencyjności, wielofunkcyjności oraz globalizującego się rolnictwa. Szczególną uwagę poświęcono konfliktowi między polityką protekcjonistyczną a polityką wolnego handlu rolnego w kontekście negocjacji w ramach WTO. Przedstawiono także zmiany w polityce wspierania producentów rolnych w krajach OECD i UE, wykorzystując mierniki wsparcia producenta: PSE oraz NAC.
Czynniki determinujące poziom kosztów eksploatacji sprzętu rolniczego W gospodarstwach indywidualnych
Authors: Szuk Tomasz
Published: January 2024

Badania przeprowadzono w gospodarstwach indywidualnych województwa opolskiego w 2003 roku. Celem badań było określenie wpływu czynników ekonomiczno-organizacyjnych na poziom kosztów eksploatacji posiadanego sprzętu technicznego. Uzyskane wyniki potwierdziły hipotezę, że w największym stopniu na poziom jednostkowych kosztów eksploatacji wszystkich badanych środków mechanizacyjnych, wpływają obszar gospodarstwa i poziom ich rocznego wykorzystania.
Creative Pedagogy as a Practice of Resistance: Rhizo-textual analysis of Artist Educators’ Practices within Differing European Curriculum Policy Contexts.
Authors: Stephenson Lisa , Björk Thorkelsdóttir Rannveig , Dunbar Katie Lee , Karameri Konstantina , Jónsdóttir Jóna Guðrún
Published: January 2024

Creative learning is increasingly being recognised as a crucial part of children’s holistic education. In this paper, we critically explore our experiences as artist-educators working across four differing European countries, namely, England, Iceland, Germany, and Greece in relation to differing educational policy. These experiences of practice are set against educational policy landscapes which have progressively eroded opportunities for young people to engage in the creative arts in education across many European states. As artist educators, we are involved in a three-year Erasmus+ funded project, "arted", which aims to transfer the knowledge of artists working in education to school and home contexts in response to these eroded opportunities. Using Deleuzian theory (Deleuze and Guattari, 2004) and narrative inquiry, to offer an alternative reading of policy texts, we examine our own ideologies of creativity and principles of practice within differing national curricular contexts. The rhizo-textual analysis (Honan, 2007) highlights the ‘pedagogical characteristics’ which have enabled us to hold resistance spaces for creative arts learning, acting as a social critique of policy. Through the process of this analysis three ethical principles emerge which underpin our interactive guides for teachers and parents within the project.
Global Science Opera: Enacting Posthumanising Creativity
Authors: Chappell Kerry , Ben-Horin Oded
Published: January 2024

This article is a theory/practice positioning paper which applies posthumanising creativity as a conceptual framework for Global Science Opera (GSO) practice, in the context of global education/citizenship and STEAM education. Through this positioning we demonstrate how GSO has potential to help students to globally attend to wicked problems from within education, and how posthumanising creativity might prove a productive way to understand creativity more generally within education. The Global Science Opera (GSO) emerged as a practice in 2014, at the intersection of developing agendas in STEAM (Science, Technology, Engineering, Arts and Maths) education, and global education and citizenship. Since this time GSO has been implemented on a global scale with a remit to explore the interweaving of arts, sciences and technology within a creative and democratic inquiry process which necessarily crosses geographical and other boundaries. The article considers the intersections of posthuman understandings of creativity, STEAM and global education and goes on to articulate GSO in relation to these. This includes discussion of how GSO creative process might be shaped through this positioning and how GSO creative pedagogies might manifest. The article concludes by offering insights into how GSO and posthumanising creativity might symbiotically productively move forward.
Review on Prevalence and Antimicrobial Resistance of Poultry Salmonella in Ethiopia
Authors: Haile Tamirat
Published: January 2024

Salmonellosis is one of the major causes of morbidity and mortality in village and large scale poultry farms. This paper was aimed to review on the prevalence and antimicrobial resistance of poultry Salmonella in Ethiopia. The risk factors associated with Salmonella in laying hens that the presence of previous Salmonella infection, multi-age management, cage housing systems, rearing pullets on the floor, induced molting and in-line egg processing were factors associated with Salmonella infection. Among them, many isolates were S. braenderup, S. typhimurium var. copenhagen, S. anatum and S. typhimurium isolates were dominant Salmonella serotypes. Antimicrobial resistance is a global problem in general, but it might be more severe in Ethiopia where there is lack of antimicrobial resistance assessments of Salmonella and lack of rigorous regulations. During the last decade, there has been an alarming increase in the appearance of antibiotic-resistant bacteria as a result of poor management in antibiotic utilization. Poultry Salmonella are excellent examples of diseases that have decreased in prevalence in some of the developed countries or have been eradicated by application of basic management procedures or eradication programs. Every effort should be made to eradicate Salmonella and treatment should be the last option.
Nutraceutical Properties of Potentially Pollen Sources in Riyadh, Saudi Arabia and their Impact on the Activities of Honey Bee Colonies
Authors: A Amro
Published: January 2024

Pollen plants is the sole source of strength for honey bees’ colonies, estimating pollen nutritional value is a crucial aspect to comprehend its influence on the growth of honey bee colonies in any region. In this study the potentially discovered pollen source in Riyadh region, central Saudi Arabia, Asian mustard (Brassica tournefortii Gouan.), willow wattle (Acacia salicina Lindl.), mesquite (Prosopis juliflora (Sw.) DC.) and cat’s head (Tribulus terresetris L. var. terrestris) were evaluated and their role in improving honey bee colonies were analyzed. Important criteria for determining the nutraceutical properties of pollen included fresh and dry weight, protein content, and the presence of essential and non-essential amino acids were analyzed. The study revealed that the highest content of protein in the dominant pollen types was recorded for B. tournefortii pollen (20.53%), while P. juliflora pollen was the highest in essential amino acids content. In conclusion, in an effort to achieve highquality development, careful plant breeding and rehabilitation of these potentially discovered pollen plant species would be taken into consideration. In conclusion, wise use and rehabilitation of these potentially identified bee plant species shall be considered in attempting beekeeping development.
Escobar Syndrome in Three Patients of Two Unrelated Families
Authors: Islam Kediha Mohamed
Published: January 2024

“Escobar syndrome” or “multiple pterygium syndrome” is a very rare disorder. It is characterized by congenital contractures (arthrogryposis), excessive webbing (pterygia) and scoliosis. The diagnosis is generally confirmed after birth, in the neonatal period. We describe three individuals, from two consanguineous Algerian families, affected by this syndrome. The genetic defect is a mutation of the foetal subunit of Acetyl Choline receptor.
Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling that Limits Bone Regeneration and Hair Growth
Authors: Kostenuik Paul J
Published: January 2024

Platelet-rich plasma (PRP) is a popular autologous therapy in the tissue regenerative technology space based on its enriched milieu of platelet-released growth factors (GFs), including platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). PRP is frequently used for hair restoration, wound healing, tendon and ligament repairs, and other soft-tissue settings, but PRP did not fulfill its original promise for enhancing bone grafts and bone augmentation in dentistry or orthopedics because it does not consistently promote osteogenesis. The effects of PRP on bone regeneration are often described as controversial, contradictory, and confusing, including evidence that greater platelet enrichment often leads to lesser osteogenic responses. The latter paradox suggests that limited PRP efficacy in bone regeneration may relate to platelet-derived factors that inhibit osteoblasts rather than inadequate GF concentrations. One candidate platelet-derived anti-osteogenic factor is Dickkopf-1 (DKK1), a potent soluble inhibitor of Wnt signaling that limits bone regeneration after bone damage. Recognizing that platelets store DKK1 in their alpha granules and rapidly release it upon platelet activation, we evaluated levels of DKK1, PDGF, and VEGF in human serum, plasma, platelet-poor plasma (PPP), and PRP. Sclerostin, another inhibitor of Wnt signaling that limits bone formation in undamaged bone, was also evaluated because platelets are not known to secrete sclerostin. We show that DKK1, PDGF, and VEGF concentrations are much higher in serum versus plasma, probably due to platelet activation during serum preparation. DKK1, PDGF, and VEGF concentrations were also higher in PRP versus plasma, and in plasma versus PPP. Activation of plasma or PRP with thrombin resulted in marked increases in DKK1, PDGF, and VEGF concentrations, with DKK1 levels in activated PRP being over 40-fold higher than the minimum concentration reported to inhibit osteogenesis in cell culture models. Conversely, sclerostin levels in plasma and PRP were unaffected by platelet activation and were significantly lower in serum versus standard plasma, providing new evidence that platelets do not secrete sclerostin. These results suggest that the beneficial effects of high GF levels in PRP may be limited by the presence of high levels of DKK1 released from the same platelet alpha granules.
Effectiveness of Local Surgical Site Infiltration and Regional Nerve Blocks for Elective Foot Surgery Adnan a Faraj, Lesley Scanlone
Authors: Faraj Dr. Adnan A
Published: January 2024

Introduction: Peripheral nerve block for pain relief in elective foot surgery is recommended by the national institute for clinical excellence. The aim of the current study was to evaluate this. Material and Methods: In a retrospective study on the quality of pain relief in 100 patients undergoing elective foot and ankle surgery using, the degree of pain relief, and the duration of anaesthesia was analysed. Three methods of local infiltration was used, US guided, guided by anatomical landmark and local infiltration at site of surgery. The data was collected using a questionnaire, assessed and discussed with the anaesthetic and the orthopaedic team. The surgery was for elective foot conditions with the patient under general anaesthesia. Results: Local surgical site infiltration was used in in 40 cases, Ultrasound guided (USG) local anaesthetic injection was given for 30 of cases, and infiltration using anatomical land mark was given in for 30 cases. The duration of anaesthesia was longer when USG block was used after general anaesthesia. The degree of pain relief was similar between blocks and local surgical site infiltration. Conclusion: Local surgical site infiltration at the end of the operation is effective in pain relief following foot surgery and is less time and cost consuming.
Jesus Duenas Becerra in the Rhythmic Lines of the Founding of Psicoballet
Authors: Becerra Jesus Duenas
Published: January 2024

During the month of last October, the XI International Psychoballet Cuba 2023 Meeting was held in Havana. Dr. Jesús Dueñas Becerra was at the event dedicated to its founders, as well as to the emblematic figures of those first 50 years of the method, genuinely Cuban..
Evaluation of Consumer Attitudes: Attributes of Langsa Hutan Lindung Park Tourism Services
Authors: Amilia Suri , Zati Muhammad Rizqi , Rosalina Dhian
Published: January 2024

Attitude is a combination of motivation, emotion, and perception of an aspect of an individual's life. Consumer attitude is an emotional expression of consumers that shows whether consumers like an object or not so that attitudes can describe the level of consumer confidence in products or services. Consumer attitudes on tourism service attributes describe what priority attributes are taken into consideration in choosing and visiting tourist sites. The purpose of this study is to analyze consumer attitudes towards the Langsa hutan lindung park tourism services. This research is a quantitative descriptive using Fishbein's multi-attribute method. Fishbein's Multiattribute Model can measure consumer attitudes using three components: the level of importance, trust, and attitude evaluation. There are one hundred tourists who are visiting and selected using accidental sampling. The results of this study indicate that research respondents have a positive attitude towards all fourteen attributes of protected forest tourism marketing services, and two of them are very positive about two attributes: the level of crime rate and the spacious parking lots.
Transformational Leadership in Improving Employee Integrity at Lembaga Perkreditan Desa (LPD) in Bali Province
Authors: Adhika I Nyoman Resa , Riana I Gede , Wibawa I Made Artha , Putra Made Surya
Published: January 2024

Growth in the number of LPDs is not followed by the amount of profit growth. There has been a decline in profit from 2020 to 2021. The decline in assets occurred by 3 percent until December 2020 compared to 2019. Meanwhile, in 2021 the decline in assets was 0.02 percent compared to 2021. A total of 130 LPDs were recorded as no longer operating. Until 2022, there are 36 LPDs experiencing legal problems due to a lack of employee integrity. This study was conducted to find answers to the question of how the influence of transformational leadership on employee integrity in LPDs in the Bali region. This study designed a quantitative approach. Quantitative analysis using structural equation model with PLS. The research was conducted in LPDs in nine regencies/cities in Bali Province with 1,437 units. The findings of this study are that the role of leadership in improving employee integrity is very important. Leadership acts as a driving force for employees so that employee integrity can be applied optimally in LPD. In building employee integrity, leaders must have a firm and straightforward commitment to support employees to apply good integrity in providing services to villagers, so that LPD can continue to develop sustainably, and employees have a sincere dedication to serving villagers.
Using Multimedia Interactive Learning Informatics Materials in Junior High Schools on Increasing Students’ Cognitive Abilities
Authors: Puput Tri Anggara  , Herman Dwi Surjono
Published: January 2024

The informatics learning process so far has yet to be completely effective. causing students' abilities and learning outcomes to be low. This research aims to develop interactive learning multimedia products in junior high schools to improve students' cognitive abilities. This type of research is development research. The model used to create products is Alessi and Trollip, which consists of 1) planning, 2) design, and 3) development. Product testing consists of alpha and beta tests, used to determine the level of product feasibility, and effectiveness tests, used to determine the level of product effectiveness on students' cognitive learning outcomes. The product alpha test, product beta test and effectiveness test involved 30 students. To collect data using interviews, observations, questionnaires and tests. The data that has been collected is then analyzed using qualitative descriptive methods. The research results, namely the results of product testing in the alpha test, rated this multimedia in the very feasible category with an average score of 3.75 by media experts and 3.50 by material experts. The beta test results also placed this multimedia in the very doable category with an average score of 3.68 and a Gain score of 0.725, included in the High criteria. It was concluded that interactive learning multimedia is suitable for use in learning. The use of interactive multimedia learning information materials can significantly increase students' learning motivation and cognitive learning achievements.
Audio-Visual Based Picture Story Media for Elementary School Students
Authors: Resky Satriya Restu , Eni Fariyatul Fahyuni
Published: January 2024

Religious education is important in shaping students' religious understanding and practice. In this regard, the research aims to develop audio and visual-based Islamic picture story learning media to increase understanding of prayer for elementary school students. This type of research is development research using the ADDIE model. The product validity test subjects were 1 learning material expert, 1 learning media expert, and 1 learning expert. The subjects for the product trial (product practicality test) were 19 grade III elementary school students. The methods used to collect data are observation, questionnaires and tests. The instruments used to collect data were questionnaire sheets and test question sheets. Data analysis techniques use qualitative descriptive analysis, quantitative descriptive analysis and inferential statistics. The research results, namely the results of assessments from learning material experts, learning media experts, and learning experts, received a score of 98%, resulting in very good qualifications. The assessment results the students gave received a score of 93.55%, resulting in very good qualifications. The t-test results showed a significant difference in increasing understanding of prayer between the experimental class group and the control class group. It was concluded that Islamic picture story learning media based on audio and visuals effectively increased elementary school students' understanding of prayer.The implication of this research is that the media developed can be used in learning.
Risk factors for the alzheimer's disease. Systematic review and meta-analysis
Authors: Khasanova G. R. , Muzaffarova M. Sh.
Published: January 2024

The “aging” of the population increased the importance of researches in the field of the epidemiology of chronic diseases, including Alzheimer's disease (AD) -the most common cause of dementia in the population.

Aim. The role of potential risk factors for AD through a systematic review and meta-analysis. The “aging” of the population has updated research in the field of the epidemiology of chronic diseases, incl. Alzheimer's disease (AD) is the most common cause of dementia in the population. The aim of the study was to assess the role of potential risk factors for AD through a systematic review and meta-analysis.

Materials and Methods. Using the electronic databases PubMed, Scopus, E-library, a search was made for articles in Russian and English, published from 1995 to 2022. In accordance with the clinical question, using the PECO formula, papers were selected in which the authors investigated the role of various risk factors in groups with and without AD. The study was carried out in accordance with the international guidelines for writing systematic reviews and meta-analyses "PRISMA". Study quality was analyzed using the Newcastle-Ottawa scale for cohort and case-control studies. The degree of heterogeneity was assessed using the chi-square test and the I2 coefficient. Publication bias was analyzed using a funnel plot. We used the software Review Manager 5.3 and Microsoft Office Excel 2010.

Results. Initially, 3197 articles were retrieved from the databases; After screening and eligibility analysis, 17 studies were included in the me-ta-analysis (11 case-control studies and 6 cohort studies). Totally, these publications included data from 134,732 people with a confirmed diagnosis of AD and 1,058,143 respondents without AD (control group). According to the results of the meta-analysis, significant risk factors were: heredity (odds ratio (OR) 1.82; 95% confidence interval (95% CI) 1.66-1.99), arterial hypertension (OR 1.65; 95% CI 1.29-2.13), hypercholesterolemia (OR 1.25; 95% CI 1.13-1.38), obesity (OR 1.13; 95% CI 1.09-1.17), presence of diabetes mellitus 2 type (OR 1.36; 95%; CI 1.15-1.62), low level of education (OR 1.61; 95% CI 1.18-2.18), depression (OR 1.35; 95% CI 1.03-1.76). There was no relationship with alcohol consumption, smoking, a history of myocardial infarction and / or coronary heart disease, a history of acute cerebrovascular accident, insomnia, female gender, traumatic brain injury.

Conclusion. The conducted meta-analysis allowed to obtain confirmation of the role of various potential risk factors for AD; at the same time, many of them are modifiable and are associated with metabolic disorders, which can probably be involved into the process of accumulation and deposition of beta-amyloid in the cells of the nervous system. Continued research on this issue could contribute to the development of prognostic scales and personalized recommendations for the prevention of this currently incurable disease.
Endometrial hyperplasia and endometrial polyps: clinical and anamnestic characteristics of women
Authors: Kravchenko E. N. , Lautenschleger E. V.
Published: January 2024

Aim. To study the clinical and anamnestic characteristics of patients with endometrial hyperplasia (EH) and endometrial polyps (PE).

Material and Methods. a retrospective study was conducted, which included 267 sick women of reproductive and perimenopausal age who sought gynecological care at «Euromed» in 2022-23, who, before receiving the examination results, were diagnosed with N92 - heavy, frequent and irregular menstruation. Depending on the results of the pathomorphological examination, the patients were divided into 3 groups: group A included 89 patients with GE; group B – 99 women with PE; Group B (control) included 79 patients in whom endometrial pathology was excluded.

Results. Among all women who came to the clinic with heavy menstrual bleeding, 33.3% had GE, 37.1% had PE, 29.6% had BUN-O ovulatory dysfunction. GE without atypia was detected in 72 (80.9%) cases of group A, GE with atypia – in 7 (19.1%), in group B PE was diagnosed in 91 (91.9%) cases, PE with atypia – in 28 (8.1%).

In group B, in 22 (27.8%) cases, the endometrium was identified in the proliferation phase, in 57 (72.2%) cases, the endometrium was identified in the phase of incomplete secretion.

Conclusion. Women with GE are characterized by early menarche, absence of pregnancies and childbirth during life associated with the woman’s choice, contraception, endocrine diseases, obesity, polycystic ovary syndrome, ovarian tumors, heavy bleeding with clots during menstruation, menstruation for more than 8 days, chronic iron deficiency anemia. Women with endometrial polyps are characterized by arterial hypertension, uterine fibroids, adenomyosis, infertility, dysmenorrhea, chronic endometritis, a history of cervicitis and vaginitis; clinical manifestations include intermenstrual bleeding.
Biocompatibility and features of degradation of polymer anti-adjection membranes with antibacterial activity
Authors: Kudryavtseva Yu. A. , Kanonykina A. Yu. , Efremova N. A. , Koshelev V. A.
Published: January 2024

When performing operations on the abdominal and thoracic organs, the main share of postoperative complications is represented by the formation of adhesions or the development of an infectious process, which leads to a decrease in the quality of life of patients, the need for reoperation and often causes deaths. A solution to this problem can be the use of intraoperative biodegradable anti-adhesion membranes that have their own antibacterial activity.

Aim. Development of polymer anti-adhesion membranes with their own anti-inflammatory and antibacterial activity, assessment of their biocompatibility and biodegradation in in vivo experiments

Materials and Methods. The membranes are made by electrospinning from a composition of biodegradable polymers: polylactide-co-glycolide copolymer (50:50) and polylactide-co-glycolide (85:15). To impart antibacterial properties to the membrane, the antibiotic Tigacil was added to the polymer solution in various dosages - 0.125; 0.25 and 0.5 mg/ml polymer solution. The antibacterial activity of the membranes in vivo was assessed. The physical and mechanical properties were studied and the surface structure of the membranes was assessed using a scanning electron microscope. Biocompatibility and dynamics of biodegradation were assessed in vivo by implantation into laboratory animals (rats) for periods of 14 days, 1, 2 and 3 months, followed by histological examination of explanted samples.

Results. Polymer membranes made by electrospinning, without the inclusion of Tigacil, consist of threads whose thickness was 1.63 microns (1.422.85 microns); when Tigacil is included in the fiber composition, the fiber thickness decreases to 1.2 microns (0.977 - 1.89 pm), while the threads are more densely and orderly located. The strength and elasticity modulus of membranes with Tigacil are almost 2 times higher than those of samples without the inclusion of the drug. The maximum antibacterial effect was achieved at a Tigacil dosage of 0.5 mg/ml - the zone of inhibition of Staphylococcus aureus at a Tigacil concentration of 0.125 mg/ ml was 146%, 0.25 mg/ml - 152% and at a concentration of 0.5 mg/ml - 11 .5 mm 177%. The inclusion of Tigacil led to a decrease in the rate of biodegradation of samples in vivo. The samples underwent biodegradation without signs of acute and chronic inflammation.

Conclusion. The inclusion of Tigacil in the membrane gives it antibacterial properties, and the optimal concentration of Tigacil was 0.5 mg/ml of the polymer solution. The inclusion of Tigacil in the polymer composition affects the morphology of the membranes, increases the strength and elastic modulus, which led to a decrease in the rate of degradation when implanted subcutaneously in rats. The absence of signs of inflammation confirms the biocompatibility of the developed membranes.
Hypoxia-inducible factors: details create a picture. Part II. HIF-2
Authors: Ignatenko G. A. , Bondarenko N. N. , Dubovaya A. V. , Ignatenko T. S. , Valigun Ya. S. , Belyaeva E. A. , Gavrilyak V. G.
Published: January 2024

This review presents current information on the role of hypoxia-inducible factor-2 (HIF-2) under conditions of physiological tissue hypoxia and pathological hypoxic conditions. The structural and functional features of HIF-2 subunits (HIF-2α and HIF-β) and methods of their regulation under conditions of normoxia and hypoxia are described. The spectrum of cells expressing HIF-2α is quite diverse: endothelial cells of blood vessels, kidney fibroblasts, hepatocytes, interstitial cells (telocytes) of the pancreas, epithelial cells lining the intestinal mucosa, type II alveolocytes, glial cells, derivatives of neural crest cells (chromaffinocytes of the adrenal gland). HIF-2α -dependent transcriptional effects are highly locus specific and occur only under certain circumstances. Regulation of HIF-2α translation can be accomplished by two classes of regulatory molecules (RNA-binding proteins and mR-NAs) by altering the rate of translation due to binding to the 3' or 5' untranslated region of mRNA (3' or 5' UTR) of specific targets. HIF-2α activity is regulated primarily at the post-translational level by various signaling mechanisms at the level of mRNA expression, mRNA translation, protein stability, and transcriptional activity. Under normoxia, the canonical regulation of HIF-2α activity is determined by oxygen-dependent mechanisms, and under hypoxia conditions - by non-canonical (oxygen-independent) mechanisms, through phosphorylation, SUMOlyated, acetylation, methylation, etc., causing positive and negative effects. It has been established that HIF influences signaling pathways affecting embryonic development, metabolism, inflammation and the physiology of functional systems, and also works in long-term responses to chronic hypoxia, during which it regulates angiogenesis, glucose, iron, lipid metabolism, cell cycle, metastasis and other processes. Studying changes in the intracellular content of HIF-2α and the transcriptional activity of HIF-2 will allow us to develop effective methods for correcting various diseases accompanied by systemic and local oxygen deficiency.
A Wire Guide for Transosseous Osteosynthesis of the Lumbar Spine in Dogs
Authors: Antonov N. I.
Published: January 2024

Introduction. The transosseous osteosynthesis method is actively used both for pathologies of limb bones and for pathologies of the axial skeleton in dogs. The insertion of the fixators through the bodies of the lumbar vertebrae requires the surgeon’s skill and precision in determining the insertion point and direction. To help novice traumatologists, a wire guide has been developed to insert the wires through the structures of the lumbar spine.Materials and Methods. The study was performed on the basis of the experimental laboratory of the Ilizarov Centre (Kurgan city). As part of the state task, lateral interbody fusion was performed at the L4–L6 level with simultaneous bilateral posterior arthrodesis of the sacroiliac joint and external controlled transosseous osteosynthesis of the lumbar spine in 12 adult mongrel dogs. The insertion of wires through the lumbar vertebrae was performed using a wire guide for osteosynthesis of the spinal column, which was assembled from parts of the Ilizarov fixator. The wire guide consists of standard parts of the Ilizarov apparatus: a beam, one radius bar and nine short bars, threaded rods, bolts, flange nuts and two frame dismountable wire clamps. Next, the fixation of wires on the external supports was carried out according to the accepted method. After osteosynthesis, clinical and neurological studies were performed.Results. After the dog was placed on the operating table, the distances from the external cues to the wire insertion points were calculated according to the radiographs. Two wires were put in the fixator at the required levels and, following the technique, a wire was inserted through the structures of the lumbar vertebra using a wire guide. No iatrogenic injuries were observed when using the wire guide. Clinically, after application of the external fixation device on the lumbar spine, on the next day after surgery and thereafter, preservation of all reflexes and functions of the pelvic limbs was observed. Clinical and neurological studies have confirmed the safe insertion of wires through the bodies of the lumbar vertebrae.Discussion and Conclusion. The use of the wire guide is recommended for a novice traumatologist, proficient in the method of transosseous osteosynthesis. The wire guide allows the doctor to orientate himself when inserting the wires through the structures of the spine, in order to avoid iatrogenic damage to the spinal cord and abdominal organs.
Valvojista VAR-teknologiaan
Authors: Nevala Arto
Published: January 2024

Jalkapallosääntöjen puhtaasti inhimillisestä soveltamisesta on 2000-luvulla siirrytty teknologian käyttöön osana tuomitsemiskäytäntöjä. Kansainvälisellä ja osin kansallisella huipulla erotuomarien edellytetään käyttävän teknisiä apuvälineitä tiettyihin sääntökohtiin liittyvissä pelitilanteissa oikean ratkaisun tekemiseksi. Tunnetuin esimerkki on VAR-järjestelmä (Video Assistant Referee).Modernin jalkapallon yli 160-vuotisessa historiassa teknologian käyttö kattaa vain lyhyen jakson. Se linkittyy jalkapallon tuomitsemiskäytäntöjen historiaan ja perinteiseen oikeudenmukaisuuden ja reiluuden lähtökohtaan mutta myös jalkapallon viime vuosikymmenten muutoksiin eli markkinallistumiseen, teknologisoitumiseen ja eriytymiseen. Inhimillinen havainnointi ja erotuomarin päätösten lopullisuus olivat 2000-luvulle saakka tuomitsemiskäytäntöjen perusta, vaikka jalkapallo pelinä ja yhteiskunnallisena ilmiönä muuttui. Teknologisten sovellutusten nopea kehitys mursi lopulta vanhan asetelman, ja teknologian käytöstä tuli osa huippujalkapallon tuomitsemista. Samalla tämä kehitys kiihdytti jalkapallon eriytymistä eli huippujalkapallon ja lajin ruohonjuuritason etääntymistä. Teknologian soveltamisen lisäksi eriytymistä kiihdyttivät myös markkinallistuminen sekä huippujalkapallon kiinnittyminen entistä selvemmin osaksi mediateknologiaan nojaavaa viihdeteollisuutta.Avainsanat: jalkapallo, erotuomari, säännöt, historia, VAR-teknologiaFrom Umpires to VAR Technology. The Technologization of Refereeing as Part of the Change in Football Culture from the 19th Century to the 2020sIn the 2000s, there has been a shift in the application of football rules to the use of technology as part of refereeing practices. At international and partly national level, referees are required to use technology in four types of decisions in order to prevent human errors and make right decisions. The most famous example of technology is the so-called VAR system (Video Assistant Referee).In the more than 160-year history of modern football, the use of technology constitutes only a short period. It is linked to the history of football refereeing practices and the traditional premise of fairness, but also to the changes in football in recent decades, i.e. marketisation, “hypercommodification”, technologization, and differentiation. Until the 2000s, human observation and finality of referee decisions were the basis of refereeing practices, although football as a game and social phenomenon changed. The rapid development of technological applications eventually broke the old barriers, and the use of technology became part of top football and, at the same time, a factor accelerating the differentiation of football.Keywords: football, referee, rules of the game, history, VAR technology