bluuebunny/crossref_metadata_2025 huggingface dataset:
Comunicación masiva - culturas tradicionales: un estudio sobre persistencia y transformación en las fiestas del pueblo de Conkal, Yucatán
Authors: Quiroz Carranza Roxana , Escalante Góngora Gretty
Published: July 2020

Esta investigación tuvo como objetivo identificar lo que persiste y lo que se ha transformado en las fiestas del pueblo que se celebran en la localidad de Conkal, Yucatán, tanto en su componente festivo como religioso. Ocupa un lugar especial la búsqueda de la relación medios masivos de comunicación culturas tradicionales a través de las tres principales fiestas del pueblo que se efectúan anualmente en Conkal. La información proviene del conocimiento, intereses y prácticas que en torno a las fiestas del pueblo tienen los niños y niñas que acuden a las cuatro escuelas primarias de la localidad: la “Rafael Ramírez Castañeda”, la “Margarita Maza de Juárez”, la “Marcial Cervera Buenfil” y la “Rodolfo Menéndez de la Peña”. Asimismo, de informantes claves de la comunidad y del trabajo etnográfico realizado por el equipo de investigación. El estudio inició en mayo de 2004 y culminó en abril de 2006, lo que permitió indagar las tres fiestas que se celebran a lo largo de un año.
Corrección de la acidez del suelo: efectos en el crecimiento inicial del café.
Authors: Sadeghian Siavosh , Díaz-Marín Carolina
Published: July 2020

La acidez del suelo ha sido considerada una limitante común para la producción de café en la mayoría de las regiones de Colombia. Esta investigación tuvo como objetivo determinar el efecto de la corrección de la acidez del suelo en el crecimiento inicial de café (Coffea arabica L.). Para cinco suelos representativos de la zona cafetera de Colombia y con valores de pH<5,2 se determinó el efecto de dosis crecientes de cal (0,00 1,25, 2,50, 5,00 y 10,00 g dm-3) en la biomasa seca total de las plantas, durante la fase de almácigo (seis meses). Con la aplicación de los tratamientos se logró corregir la acidez (pH y Al3+) e incrementar los contenidos de Ca2+ y Mg2+ en todos los suelos estudiados, presentando algunas variaciones entre estos. En tres de los suelos se presentó efecto de los tratamientos en la materia seca de las plantas, respuesta que se relacionó principalmente con el aumento del pH y la neutralización del Al+3. El mayor crecimiento de las plantas (rendimientos relativos entre el 95 y 100%) se asoció con los siguientes rangos de las propiedades e indicadores del suelo: pH 4,9-5,7, Ca2+ 5,1-11,2 cmolc kg-1, Mg2+ 0,9-2,1 cmolc kg-1, saturación de bases 21%-45%, Ca:Mg 4,4:1-7,4:1, Ca:K 7:1-37:1, Mg:K 1,4:1-4,8:1, Al3+ < 1,1 cmolc kg-1 y saturación de Al+3 < 12%.
Resistencia genética a la Enfermedad de la Cereza del Café en variedades cultivadas en Colombia.
Authors: Maldonado Carlos Ernesto , Ángel-Giraldo Lucia
Published: July 2020

La enfermedad de las cerezas del café (CBD), antracnosis causada por el hongo Colletotrichum kahawae subsp. kahawae, ha sido registrada solo en África y puede ocasionar pérdidas de producción hasta del 80%. Cenicafé desarrolla variedades resistentes a las enfermedades más limitantes para el cultivo, aún en ausencia de los patógenos en Colombia, usando al Híbrido de Timor (HT) como la principal fuente de resistencia a la roya del cafeto y a CBD. El propósito de este estudio fue conocer la presencia del gen Ck-1 de resistencia a CBD en las principales variedades de café cultivadas en Colombia, establecer la correlación entre la presencia de Ck-1 y la respuesta a inoculación de hipocótilos y explorar las bases genómicas de la resistencia. Los marcadores moleculares ligados a Ck-1 se ubicaron en el cromosoma 1 de Coffea canephora, región genómica con quince genes de resistencia a enfermedades. Se encontraron marcadores para Ck-1 en todas las líneas mejoradas derivadas del HT-1343 y ausentes en las variedades Típica, Borbón y Caturra, y en líneas derivadas del HT-832/1. No hubo correlación entre las formas alélicas de resistencia a CBD y la resistencia medida por inoculación de hipocótilos. La alta frecuencia de formas alélicas asociadas con resistencia a CBD en materiales seleccionados por resistencia a roya sugiere cosegregación de genes de resistencia para ambas enfermedades. La estrategia de variedades multilínea desarrolladas por Cenicafé, que actualmente corresponde a cerca del 80% del café sembrado en el país, hace que la población en general esté protegida ante la eventual llegada del patógeno a Colombia.
A diagnózisalapú felzárkózási stratégia és annak végrehajtása
Authors: Hornyik Zsuzsanna
Published: July 2020

During the talk with Miklós Vecsei, vice president of the Hungarian Maltese Charity Service and commissioner of the Prime Minister for coordination of preparation and implementation of the diagnosis based catching-up strategy for Roma were unintended also many actual and serious problems discussed. In the discussion were mentioned beside catching-up and its definite implementation also other serious problems, like domestic violence, especially the behaviour of men against women. Miklós Vecsei had a real story for everything that made narratives really authentic and it turned out that even unacceptable situations were – as far as possible – solved tenderly and humorously because there is no other way in his opinion. In his person we got known a man looking for solutions in every case and not afraid to prevent problems, and beside all of that his main aim is to help in the fastest and most effective way for indigents under consideration so that they not only accept the help but cooperate actively in forming their fate. Why is it advantageous that the implementation of the catching-up program came under control of the Minister of Interior, what diagnosis based catching-up means and what is the responsibility of the society. We got answers on all that in the interview conducted by Zsuzsanna Hornyik.
MODERN APPROACHES TO THE IMPLEMENTATION OF INTEGRATED LOGISTICS
Authors: Zimin A. S. , Rojko D. S.
Published: July 2020

The article is devoted to the problems of implementing effective integration in the field of logistics. It outlines the advantages of this area in the field of logistics, and also describes approaches to improving integration processes.
TEACHING A PROFESSIONALLY-ORIENTED FOREIGN LANGUAGE AT A UNIVERSITY UNDER THE CONDITIONS OF NEO-INDUSTRIAL ECONOMIC DEVELOPMENT
Authors: Vorob’eva I. A.
Published: July 2020

The article is devoted to professionally-oriented a foreign language teaching at a university, which today is one of the links of training a competitive specialist. The author describes the meaning of practical application of a foreign language. The problem of searching a way to improve the quality of foreign language teaching of university students is considered. A foreign language is considered as a means and as a way to improve the professional competence of a university student.
THE MNE-TECHNICAL APPROACHES TO TEACHING HIEROGLYPHIC KEYS (RADICALS) OF IDEOGRAPHIC WRITING IN JAPAN AND CHINA
Authors: Strel’nikov I. A. , Strel’nikova N. V.
Published: July 2020

In the article various approaches to the use of mnemonic techniques in teaching key characters of Japanese and Chinese characters were discussed. The retrospective analysis of mnemonics in a historical aspect is given, modern approaches to mnemonics in pedagogical theory and practice are considered.
New Analytic Solutions for Galaxy Evolution. II. Wind Recycling, Galactic Fountains, and Late-type Galaxies
Authors: Lapi A. , Pantoni L. , Boco L. , Danese L.
Published: July 2020

We generalize the analytic solutions presented in Pantoni et al. by including a simple yet effective description of wind recycling and galactic fountains, with the aim of self-consistently investigating the spatially averaged time evolution of the gas, stellar, metal, and dust content in disk-dominated late-type galaxies (LTGs). Our analytic solutions, when supplemented with specific prescriptions for parameter setting and with halo accretion rates from N-body simulations, can be exploited to reproduce the main statistical relationships followed by local LTGs; these involve, as a function of the stellar mass, the star formation efficiency, the gas mass fraction, the gas/stellar metallicity, the dust mass, the star formation rate, the specific angular momentum, and the overall mass/metal budget. Our analytic solutions allow us to easily disentangle the diverse role of the main physical processes ruling galaxy formation in LTGs; in particular, we highlight the crucial relevance of wind recycling and galactic fountains in efficiently refurnishing the gas mass, extending the star formation timescale, and boosting the metal enrichment in gas and stars. All in all, our analytic solutions constitute a transparent, handy, and fast tool that can provide a basis for improving the (sub-grid) physical recipes presently implemented in more sophisticated semi-analytic models and numerical simulations, and can serve as a benchmark for interpreting and forecasting current and future spatially averaged observations of local and higher redshift LTGs.
A New Comprehensive Data Set of Solar Filaments of 100 yr Interval. I.
Authors: Lin GangHua , Zhu GaoFei , Yang Xiao , Song YongLiang , Zhang Mei , Liu Suo , Wang XiaoFan , Su JiangTao , Zheng Sheng , Zhang JiaFeng , Tao DongYi , Zeng ShuGuang , Wang HaiMin , Liu Chang , Xu Yan
Published: July 2020

Filaments are very common physical phenomena on the Sun and are often taken as important proxies of solar magnetic activities. The study of filaments has become a hot topic in the space weather research. For a more comprehensive understanding of filaments, especially for an understanding of solar activities of multiple solar cycles, it is necessary to perform a combined multifeature analysis by constructing a data set of multiple solar cycle data. To achieve this goal, we constructed a centennial data set that covers the Hα data from five observatories around the world. During the data set construction, we encountered varieties of problems, such as data fusion, accurate determination of the solar edge, classifying data by quality, dynamic threshold, and so on, which arose mainly due to multiple sources and a large time span of data. But fortunately, these problems were well solved. The data set includes seven types of data products and eight types of feature parameters with which we can implement the functions of data searching and statistical analyses. It has the characteristics of better continuity and highly complementary to space observation data, especially in the wavelengths not covered by space observations, and covers many solar cycles (including more than 60 yr of high-cadence data). We expect that this new comprehensive data set as well as the tools will help researchers to significantly speed up their search for features or events of interest, for either statistical or case study purposes, and possibly help them get a better and more comprehensive understanding of solar filament mechanisms.
On Lithium-6 as a Diagnostic of the Lithium-enrichment Mechanism in Red Giants
Authors: Aguilera-Gómez Claudia , Chanamé Julio , Pinsonneault Marc H.
Published: July 2020

High lithium-7 (7Li) abundances in giants are indicative of nonstandard physical processes affecting the star. Mechanisms that could produce this signature include contamination from an external source, such as planets, or internal production and subsequent mixing to the stellar surface. However, distinguishing between different families of solutions has proven challenging, and there is no current consensus model that explains all the data. The lithium-6 (6Li) abundance may be a potentially important discriminant, as the relative 6Li and 7Li abundances are expected to be different if the enrichment were to come from internal production or from engulfment. In this work, we model the 6Li and 7Li abundances of different giants after the engulfment of a substellar mass companion. Given that 6Li is more strongly affected by Galactic chemical evolution than 7Li, 6Li is not a good discriminant at low metallicities, where it is expected to be low in both star and planet. For modeled metallicities ([Fe/H] > −0.5), we use a “best-case” initial 6Li/7Li ratio equal to the solar value. 6Li increases significantly after the engulfment of a companion. However, at metallicities close to solar and higher, the 6Li signal does not last long in the stellar surface. As such, detection of surface 6Li in metal-rich red giants would most likely indicate the action of a mechanism for 6Li enrichment other than planet engulfment. At the same time, 6Li should not be used to reject the hypothesis of engulfment in a 7Li-enriched giant or to support a particular 7Li-enhancement mechanism.
Discovery of a [C i]-faint, CO-bright Galaxy: ALMA Observations of the Merging Galaxy NGC 6052
Authors: Michiyama Tomonari , Ueda Junko , Tadaki Ken-ichi , Bolatto Alberto , Molina Juan , Saito Toshiki , Yamashita Takuji , Zhuang Ming-Yang , Nakanishi Kouichiro , Iono Daisuke , Wang Ran , Ho Luis C.
Published: July 2020

We report sensitive [C i] 3
P
1–3
P
0 and 12CO J = 4–3 observations of the nearby merging galaxy NGC 6052 using the Morita (Atacama Compact) Array of the Atacama Large Millimeter/submillimeter Array (ALMA). We detect 12CO J = 4–3 toward the northern part of NGC 6052, but [C i] 3
P
1–3
P
0 is not detected with a [C i] 3
P
1–3
P
0 to 12CO J = 4–3 line luminosity ratio of ≲0.07. According to models of photodissociation regions, the unusual weakness of [C i] 3
P
1–3
P
0 relative to 12CO J = 4–3 can be explained if the interstellar medium has a hydrogen density larger than

, conditions that might arise naturally in the ongoing merging process in NGC 6052. Its [C I] 3
P
1–3
P
0 emission is also weaker than expected given the molecular gas mass inferred from previous measurements of 12CO J = 1–0 and 12CO J = 2–1. This suggests that [C I]3
P
1–3
P
0 may not be a reliable tracer of molecular gas mass in this galaxy. NGC 6052 is a unique laboratory to investigate how the merger process impacts the molecular gas distribution.
Impairment of coronary flow and left ventricular function in patients with slow coronary flow phenomenon and other types of microvascular angina
Authors: Denchev Stefan , Emilova Niya , Gospodinova Mariana , Dimitrov Simeon
Published: July 2020

Purpose: We aimed at assessing the impairment in coronary flow and left ventricular function in patients without obstructive coronary disease on anti-ischemic treatment admitted with diagnosis unstable angina. Material and methods: The epicardial coronary flow was evaluated in 71 patients with unstable angina in absence of coronary stenosis >50% applying the methods the corrected TIMI frame count and systolic arrest of coronary flow at coronary angiography. The abnormalities in the diastolic function were assessed by echocardiography using PW-Doppler of the diastolic mitral flow and tissue Doppler imaging. Results:  The early diastolic velocity of interventricular septum (E’sept) and left ventricular free wall (E’ lat) were reduced in the SFLVH group compared to SCFP and the patients with normal coronary flow. Significant difference was found in between the patients with SFLVH and SCFP regarding DT and A-wave velocity in sub-analysis. The epicardial coronary flow of the patients with SFLVH was as tendency impaired compared to SCFP. The therapy with β- blocker alone or combined with calcium channel blocker or nitrate did not influence either cardiac function or coronary flow in this analysis. Conclusion:  Slower left ventricular relaxation is typical for the patients with microvascular angina and left ventricular hypertrophy associated with hypertension on treatment compared to SCFP and patients with normal coronary flow.
Echocardiographic preoperative evaluation of unbalanced atrioventricular septal defect
Authors: Vassileva Zornitsa , Kaneva Anna
Published: July 2020

Unbalanced atrioventricular septal defect is seen by 10-15% of the patients with this congenital heart disease and poses serious challenges for the treating physicians regarding the choice of the most suitable operative intervention. The forms with moderate degree of unbalance between the two ventricles, especially when the size of the left ventricle is considered borderline, make the choice between two-ventricle correction and single-ventricle palliation quite difficult. The most important factor when judging the degree of unbalance is not the size of the ventricles but rather the redistribution of blood flow. The use of different echocardiographic measurements could contribute to the more precise determination of the indications for one of the two surgical strategies with resulting improvement of patient outcome.
Acute myocarditis in a patient with parainfluenza infection, seven years after bone marrow transplantation
Authors: Marinov Nikolay , Simova Iana , Petrov Ivo
Published: July 2020

Myocarditis is an inflammatory disease of the myocardium, with heterogeneous etiology.  Although rare, myocarditis can be a complication of the influenza infection. In the majority of cases, viral myocarditis is a self-limiting infection passing without permanent changes in the myocardium. We present a clinical case of a 30-year-old woman with acute heart failure in the course of respiratory infection accompanied by severe systolic dysfunction (left ventricular (LV) ejection fraction (EF) 16%). The patient was treated according to the current guideline recommendations for the treatment of acute and chronic heart failure with the conjunction of immunomodulating and metabolic therapy. During hospitalization from microbial and viral testing, acute-phase antibodies to parainfluenza virus were identified. Following the treatment, a complete resolution of heart failure symptoms and restoration of LVEF to baseline (40%) was observed. Timely initiation of treatment in myocarditis, followed by good clinical course and regression of LV systolic dysfunction, in some cases may cancel invasive procedures such as endomyocardial biopsy.
Impairments of haemostasis and therapeutic management in patients with COVID-19
Authors: Cherneva Zheina , Cherneva Radostina
Published: July 2020

The lack of prior immunity to SARS-CoV-2 coronavirus (COVID-19) infection has led to pandemic, where there is no certain management, regarding the complications of  this viral illness. The lungs are the target organ for COVID-19 and patients develop acute lung injury that may progress to respiratory and multiorgan failure. Recent data shows the presence of diffuse bilateral pulmonary inflammation in COVID-19 infection. It is associated with a specific pulmonary vasculopathy, defined as pulmonary intravascular coagulopathy (PIC) that is distinct from disseminated intravascular coagulopathy (DIC). The coagulopathy in the early stages of COVID-19 is characterized by initial elevation of D-dimer and fibrin/fibrinogen degradation products, while abnormalities in prothrombin time, partial thromboplastin time and platelet counts are uncommon. That is why screening of D-dimer and fibrinogen levels, are mandatory. COVID-19-associated coagulopathy should be treated, following the guidelines for thromboembolic prophylaxis. Although D-dimer is a marker of mortality, current data does not show routine application of anticoagulants, unless otherwise clinically indicated. Bleeding in COVID-19 is uncommon, even when a laboratory constellation for DIC is present. However, if it occurs, standard guidelines for DIC management should be followed.
Primulina hochiensis var. ochroleuca (Gesneriaceae), a new variety from a limestone area of Guangxi, China, and errata on five new species of Primulina
Authors: Ge Yu-Zhen , Xin Zi-Bing , Fu Long-Fei , Chou Wei-Chuen , Huang Yi , Huang Zhang-Jie , Maciejewski Stephen , Wen Fang
Published: July 2020

Primulina hochiensis var. ochroleuca, a new variety from a limestone hill of karst areas, Guangxi, China is described with color photographs. It resembles P. hochiensis var. hochiensis, P. hochiensis var. ovata and P. hochiensis var. rosulata, but can be easily distinguished by a combination of characteristics, especially by its corolla color. We found only one population with approx. 3000 mature individuals at the type locality. This variety is provisionally assessed as vulnerable [VU C1] using IUCN criteria.
Lectotypification of Abies fanjingshanensis (Pinaceae)
Authors: Yang Yong , Rushforth Keith
Published: July 2020

The type collection of Abies fanjingshanensis W.L.Huang et al. contains four specimens in the Herbarium (GNUG). Abies fanjingshanensis is lectotypified here with L.Yang 83-427 (GNUG0002022) under Art. 9.12 of the Shenzhen Code.
Flowerlike hybrid horseradish peroxidase nanobiocatalyst for the polymerization of guaiacol
Authors: GÖKTÜRK Ersen
Published: July 2020

In this study, the catalytic activity and stability of flowerlike hybrid horseradish peroxidase (HRP) nanobiocatalyst (HRPCu2+) obtained from Cu2+ ions and HRP enzyme in the polymerization reaction of guaiacol were analyzed. We demonstrated that HRP-Cu2+ and hydrogen peroxide (H2O2) initiator showed significantly increased catalytic activity and stability on the polymerization of guaiacol compared to that of free HRP enzyme. Poly(guaiacol) was observed with quite high yields (88%) and molecular weights (38,000 g/mol) under pH 7.4 phosphate-buffered saline (PBS) conditions at 60 °C with 5 weight% of HRP-Cu2+ loading. HRP-Cu2+ also shows very high thermal stability and works even at 70 °C reaction temperature; free HRP enzyme denatures at that temperature. Furthermore, HRP-Cu2+ provided considerable repeated use and showed some degree of catalytic activity, even after the fourth recycle, in the polymerization of guaiacol.
“Air rage”: A systematic review of research on disruptive airline passenger behaviour 1985-2020
Authors: McLinton Sarven S. , Drury Doug , Masocha Shepard , Savelsberg Harry , Martin Lucy , Lushington Kurt
Published: July 2020

Purpose: Disruptive airline passenger behaviour (DAPB), i.e. “air rage”, has an adverse impact on crew and passenger well-being and is costly to manage and prevent. Given recent changes in airport management, aircraft design, air traffic volume and behavioural norms this review summaries research findings 1985-2020.Methodology: A systematic review of  the research literature containing qualitative or quantitative data examining DAPB. Findings: Nineteen articles satisfied the criteria for inclusion. Most studies involved surveys of cabin crew members and to a lesser extent pilots, airline representatives, passengers and business customers. Content primarily focussed on the frequency and characteristics of DAPB, whilst consequences for staff and evaluation of training to manage DAPB was less represented.  A paucity of current research was noted which is not in keeping with the changes over the last decade in the aviation industry and the increase in DAPB events.Originality: This study presents a summary of current findings on DAPB.Practical Implications: A better understanding of the environmental, social and psychological factors underlying DAPB and the effectiveness of staff training and interventions that promote a safe travel environment are required.Social Implications: The current industry trend toward sustainability and better management of security challenges must extend its focus to DAPB, in order to reverse the recent trend of social irresponsibility in air travellers.
Coordination of a supply chain with a loss-averse retailer under supply uncertainty and marketing effort
Authors: Xie Wenying , Chen Bin , Huang Fuyou , He Juan
Published: July 2020

This paper deals with a one-period two-stage supply chain, in which a loss-averse retailer facing stochastic demand orders products from a risk-neutral supplier subject to yield uncertainty. Marketing effort exerted by the retailer is employed to enhance the final market demand. We first establish a performance benchmark, and show that the wholesale price contract fails to coordinate the supply chain due to the effects of double marginalization and loss aversion. Then we propose a revenue-cost-sharing contract in order to achieve supply chain coordination. It is verified that a properly designed revenue-cost-sharing contract can achieve perfect coordination and a win-win outcome synchronously. Our results reveal that it is simple to implement and arbitrarily allocate the total channel profit between the retailer and the supplier. In addition, we examine the effect of the retailer's loss aversion degree on contract parameters and profit allocation, and we show that both the retailer and the supplier can benefit from marketing effort.
Nueva serie de dataciones radiocarbónicas sobre hueso humano para el dolmen de Los Zumacales (Simancas, Valladolid). Reflexiones sobre la temporalidad del fenómeno megalítico en la Meseta Norte
Authors: Santa Cruz del Barrio Angélica , Villalobos García Rodrigo , Delibes de Castro Germán
Published: July 2020

Se analiza la secuencia temporal funeraria de un monu­mento megalítico de la Meseta Norte, el dolmen de Los Zu­macales (Simancas, Valladolid), fechado anteriormente en torno a la primera mitad del IV milenio cal AC. La secuencia se basa en 12 nuevas dataciones radiocarbónicas por AMS obtenidas mediante huesos humanos, seleccionadas a partir del número mínimo de individuos representados en el osario. El modelado bayesiano de las fechas define un marco tempo­ral de uso entre 3846-3756 y 3627-3550 cal AC (1σ), coinci­dente con las primeras series funerarias megalíticas regionales. La concentración de la mayoría de las dataciones del IV mi­lenio cal AC revela que la utilización del dolmen fue proba­blemente más intensa en su primera etapa. Además, el análi­sis ha identificado un individuo depositado al inicio del Calcolítico, algo que, sin dejar de considerar que la fecha sea errónea, supondría el reconocimiento de una reutilización pre­histórica de la que nada se conocía hasta ahora.
Reflections on Different Learning Analytics Indicators for Supporting Study Success
Authors: Ifenthaler Dirk , Yau Jane Yin-Kim
Published: July 2020

Common factors, which are related to study success include students’ sociodemographic factors, cognitive capacity, or prior academic performance, and individual attributes as well as course related factors such as active learning and attention or environmental factors related to supportive academic and social embeddedness. In addition, there are various stages of a learner’s learning journey from the beginning when commencing learning until its completion, as well as different indicators or variables that can be examined to gauge or predict how successfully that journey can or will be at different points during that journey, or how successful learners may complete the study and thereby acquiring the intended learning outcomes. The aim of this research is to gain a deeper understanding of not only if learning analytics can support study success, but which aspects of a learner’s learning journey can benefit from the utilisation of learning analytics. We, therefore, examined different learning analytics indicators to show which aspect of the learning journey they were successfully supporting. Key indicators may include GPA, learning history, and clickstream data. Depending on the type of higher education institution, and the mode of education (face-to-face and/or distance), the chosen indicators may be different due to them having different importance in predicting the learning outcomes and study success.
HPK1 Influences Regulatory T Cell Functions
Authors: Sawasdikosol Sansana , Zha Renyuan , Fisher Timothy S , Alzabin Saba , Burakoff Steven J
Published: July 2020

Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of TCR-initiated signal transduction. Both the HPK1−/− mice and the genetically engineered mice with a point mutation that disrupts the catalytic activity of HPK1 possess enhanced antitumor immunity, especially when these mice are treated with anti–PD-L1 immune checkpoint Ab. Because CD4+FOXP3+ regulatory T cells (Tregs) play an important role in suppressing tumor immunity, we investigated whether the loss of HPK1 expression could result in the reduction of Treg functions. We found that the number of HPK1−/− Tregs is elevated relative to the number found in wild-type C57/BL6 mice. However, HPK1−/− Tregs lack the ability to carry out effective inhibition of TCR-induced proliferative responses by effector T cells. Furthermore, HPK1−/− Tregs respond to TCR engagement with an elevated and sustained Erk MAPK and p65/RelA NF-κB phosphorylation in comparison with wild-type Tregs. Also, a multiplex cytokine analysis of HPK1−/− Tregs revealed that they demonstrate an aberrant cytokine expression profile when stimulated by anti-CD3ε and anti-CD28 crosslinking, including the uncharacteristic expression of IL-2 and antitumor proinflammatory cytokines and chemokines such as IFN-γ, CCL3, and CCL4. The aberrant HPK1−/− phenotype observed in these studies suggests that HPK1 may play an important role in maintaining Treg functions with wider implications for HPK1 as a novel immunotherapeutic target.
Innate Priming of Neutrophils Potentiates Systemic Multiorgan Injury
Authors: Zhang Yao , Lin RuiCi , Pradhan Kisha , Geng Shuo , Li Liwu
Published: July 2020

Excessive inflammatory reactions mediated by first-responder cells such as neutrophils contribute to the severity of multiorgan failure associated with systemic injury and infection. Systemic subclinical endotoxemia due to mucosal leakage may aggravate neutrophil activation and tissue injury. However, mechanisms responsible for neutrophil inflammatory polarization are not well understood. In this study, we demonstrate that subclinical low-dose endotoxemia can potently polarize neutrophils into an inflammatory state in vivo and in vitro, as reflected in elevated expression of adhesion molecules such as ICAM-1 and CD29, and reduced expression of suppressor molecule CD244. When subjected to a controlled administration of gut-damaging chemical dextran sulfate sodium, mice conditioned with subclinical dose LPS exhibit significantly elevated infiltration of neutrophils into organs such as liver, colon, and spleen, associated with severe multiorgan damage as measured by biochemical as well as histological assays. Subclinical dose LPS is sufficient to induce potent activation of SRC kinase as well as downstream activation of STAT1/STAT5 in neutrophils, contributing to the inflammatory neutrophil polarization. We also demonstrate that the administration of 4-phenylbutyric acid, an agent known to relieve cell stress and enhance peroxisome function, can reduce the activation of SRC kinase and enhance the expression of suppressor molecule CD244 in neutrophils. We show that i.v. injection of 4-phenylbutyric acid conditioned neutrophils can effectively reduce the severity of multiorgan damage in mice challenged with dextran sulfate sodium. Collectively, our data, to our knowledge, reveal novel inflammatory polarization of neutrophils by subclinical endotoxemia conducive for aggravated multiorgan damage as well as potential therapeutic intervention.
Interferon-beta: treatment option against COVID-19
Authors: Ul Haq Faiz , Khan Muhammad Usman , Muazzam Ayesha , Farooq Hajrah , Iqbal Javeria , Imran Muhammad , Bashir Rabia , Ahmad Sania , Arif Sara
Published: July 2020

In December 2019, an increasing number of cases of novel coronavirus (2019-nCoV) that were linked to seafood wholesale market have identified in Wuhan, China. Taxonomist declared 2019-nCoV as severe acute respiratory syndrome coronavirus- 2 (SARS-CoV-2) and the disease termed as COVID-19. Importantly, there is no approved drugs or vaccine against SARS-CoV-2. Current review is related to address treatment option for COVID-19. Interferon-β have shown significant activity against previous outbreak of SARS-CoV and MERS-CoV. Faced with an ongoing pandemic of SARS-CoV-2 and lack of effective treatment options, identifying compounds with antiviral activity has become a high priority. Efficacy of these treatments is still unclear. Therefore, final analysis is important to develop better treatment strategies for ongoing pandemic.
Postoperative neurocognitive disorders
Authors: Tasbihgou Setayesh Reza , Absalom Anthony Ray
Published: July 2020

A decline in cognitive function is a frequent complication of major surgery. Postoperative cognitive impairments have generally been divided into short- (postoperative delirium) and long-term disturbances (postoperative cognitive dysfunction [POCD]). Long-term impairments are often subtle and overlooked. They need to be objectively assessed using neuropsychological tests to be diagnosed. Although POCD has been the subject of considerable research over the past decades, it remains uncertain why some patients do not return to preoperative levels of cognitive function. Surgery and anesthesia have both been implicated to play a role in POCD development, and certain patient-related factors, such as advanced age and low preoperative baseline cognitive function, have consistently been found to predict postoperative cognitive decline. This article will present an overview of POCD and its etiology and provide advice on possible strategies on its prevention.
Evaluation of water loss in transit and surface runoff in a Brazilian semi-arid basin
Authors: Toledo Cristian Epifanio , Nogueira João Carlos Mohn , Camargo Alexandre De Amorim
Published: July 2020

The objective of this work was to propose and evaluate a model to estimate transit water losses and surface runoff in a Brazilian semi-arid basin, fundamental components in the hydrological studies of the region, such as in the verification of hydrological connectivity. The study area was the Orós Reservoir Basin, located in the state of Ceará. The modeling of transit water loss and surface runoff were developed based on the work of Araújo and Ribeiro (1996) and Peter et al. (2014). In the proposed model, the parameter of loss in transit (k) was estimated at 0.027 km-1 for a section of the river basin, and when simulated for other stretches it provided good flow results at the end of the stretch, obtaining an NSE of 82%. The value of the runoff coefficient was estimated at 3% and when evaluating a spatial variation of this coefficient in the basin, the values varied from 2% to 12%, and the use of specialized runoff coefficient (RC) values promoted a higher NSE in the discharge simulation in the basin. It is concluded that the proposed model to estimate transit water losses and surface runoff demonstrated a high efficiency in the simulation of hydrological processes. The basin of Orós reservoir presented a high variability of the coefficient of surface runoff, justifying the need for a greater spatiality of this coefficient in heterogeneous environments.
PENGARUH MOTIVASI KERJA TERHADAP KINERJA DOSEN PERGURUAN TINGGI SWASTA LABUHAN BATU
Authors: Sakinah Ubudiyah Siregar  , Sri Milfayetti  , Ibnu Hajar  , Akmaluddin
Published: July 2020

Effect of Work Motivation on the Performance of Labuhan Batu Private University Lecturers]. This study aims to determine and analyze work motivation directly affect the performance of Labuhan Batu Private University lecturers. Subjects were Labuhan Batu Private University lecturers with a total sample of 125 people, taken by means of a random sampling formula using the Slovin formula, and data were analyzed using path analysis after calculating the correlation of all research variables in the form of a matrix. The research findings obtained work motivation has a direct effect on the positive performance of Labuhan Batu Private University lecturers. Obtained a significant path coefficient between work motivation and lecturer performance, namely: ρ65 = 0.21. Furthermore, based on the calculation of the direct influence of work motivation with lecturer performance of 0.212 = 0.044. Thus, work motivation that directly determines changes in lecturer performance is 4.4%.

Abstrak

Pengaruh Motivasi Kerja Terhadap Kinerja Dosen Perguruan Tinggi Swasta Labuhan Batu].  Penelitian ini bertujuan  mengetahui dan menganalisis  motivasi kerja berpengaruh langsung terhadap kinerja dosen Perguruan Tinggi Swasta Labuhan Batu.  Subjek penelitian adalah dosen Perguruan Tinggi Swasta Labuhan Batu dengan jumlah sampel sebanyak 125 orang, yang diambil dengan cara rumus random sampling menggunakan rumus Slovin, dan data dianalisis dengan menggunakan analisis jalur setelah dihitung korelasi seluruh variabel penelitian dalam bentuk matriks.  Hasil temuan penelitian diperoleh  Motivasi kerja berpengaruh langsung terhadap positif kinerja dosen Perguruan Tinggi Swasta Labuhan Batu.  diperoleh koefisien jalur yang signifikan antara motivasi kerja dengan Kinerja dosen, yaitu:  ρ65 = 0,21, Selanjutnya, berdasarkan hasil perhitungan pengaruh langsung motivasi kerja dengan kinerja dosen sebesar 0,212 =0,044. Dengan demikian, motivasi kerja yang secara langsung menentukan perubahan- perubahan kinerja dosen adalah sebesar 4,4 %.

Kata Kunci: motivasi kerja, kinerja dosen
PENGARUH MODEL BLENDED LEARNING ROTASI DAN KECERDASAN INTRAPERSONAL TERHADAP HASIL BELAJAR IPA DI SMP
Authors: Siti Ambarli  , Zulfiati Syahrial  , Mochammad Sukardjo
Published: July 2020

The background of this research is based on low result of science learning outcomes and usage of Information and Communication Technology (ICT) in learning process that is not optimal yet at PB Soedirman Junior High School Jakarta. The general objective in this research is to know the effect of blended learning rotation model and intrapersonal intelligence on science learning outcomes in junior high school. It was a quantitative research with an experimental method and 2x2 treatment by level design. The results of data analysis and interpretation indicates that; (1) students who were using blended learning rotation model Lab Rotation had higher learning outcomes than those by blended learning rotation model Station Rotation; (2) there was an effect of interaction between blended learning rotation model and intrapersonal intelligence on student learning outcomes in science subject; (3) students with higher intrapersonal intelligence who were using blended learning rotation model Lab Rotation had higher learning outcomes than those by blended learning rotation model Station Rotation; (4) students with lower intrapersonal intelligence who were using blended learning rotation model Lab Rotation had lower learning outcomes than those by blended learning rotation model Station Rotation.

Abstrak

Penelitian ini dilator belakangi oleh masih rendahnya hasil belajar IPA serta pemanfaatan Teknologi Informasi dan Komunikasi (TIK) dalam pembelajaran yang belum optimal di SMP Islam PB Soedirman Jakarta. Tujuan umum yang ingin dicapai dalam penelitian ini adalah untuk mengetahui pengaruh dari penggunaan model blended learning rotasi dan kecerdasan intrapersonal yang dimiliki peserta didik terhadap hasil belajar IPA di SMP. Penelitian ini menggunakan metode eksperimen dengan desain penelitian treatment by level 2x2. Hasil analisis dan interpretasi data menunjukkan bahwa; 1) peserta didik yang menggunakan model blended learning rotasi tipe Lab Rotation memiliki hasil belajar IPA yang lebih tinggi dibandingkan dengan model blended learning rotasi tipe Station Rotation; 2) terdapat pengaruh interaksi antara model blended learning rotasi dan kecerdasan intrapersonal terhadap hasil belajar IPA peserta didik; 3) peserta didik dengan kecerdasan intrapersonal tinggi yang menggunakan model blended learning rotasi tipe Lab Rotation memiliki hasil belajar IPA yang lebih tinggi dibandingkan dengan model blended learning rotasi tipe Station Rotation; 4) peserta didik dengan kecerdasan intrapersonal rendah yang menggunakan model blended learning rotasi tipe Station Rotation memiliki hasil belajar IPA yang lebih tinggi dibandingkan dengan model blended learning rotasi tipe Lab Rotation.

Kata Kunci: blended learning, lab rotation, station rotation, kecerdasan intrapersonal, hasil belajar IPA
El aprendizaje dialógico en los procesos de interacción social del contexto educativo.
Authors: Gómez Chuquimarca Ligia Valentina , Valverde Muñoz Kleber Andrés , Villón Tomalá Ana María
Published: July 2020

En la presente investigación se reconocen las potencialidades del aprendizaje dialógico en los procesos de interacción social en el contexto educativo, a partir de la identificación de los principios del aprendizaje dialógico tales como: el diálogo igualitario, inteligencia cultural, transformación, dimensión instrumental, creación de sentido, solidaridad e igualdad de diferencias. En el aprendizaje dialógico, la convivencia y el diálogo en los procesos educativos son ejes enmarcados en el respeto, la tolerancia, la asertividad y la solidaridad, promoviendo así las interacciones sociales que posibilitan cambios significativos en el contexto escolar.
Formación de competencias desde la inteligencia emocional.
Authors: Gavilánez Cárdenas Clarita Vanessa , Llumiguano Poma María Elena , Alvarado Pacheco Eddy Stalin , Chávez Chimbo Galo Wenseslao
Published: July 2020

La investigación se fundamenta en verificar los desafíos de la actual sociedad compleja a través de un enfoque por competencias que ha supuesto un giro propositivo en la estructura y metodología de los sistemas laborales. En este sentido, se determina que se ha olvidado de aspectos básicos cuya inclusión merece ser revisada dada la relevancia que se tiene sobre la efectividad en los procesos del ámbito laboral. El trabajar sobre las emociones positivas y sobre la inteligencia emocional constituyen esos aspectos olvidados, lo que repercute en resultados positivos de logro y de bienestar personal, social, y por ende, en el desarrollo de la organización. El estudio justifica la necesidad de desarrollar y adquirir competencias emocionales en los sistemas laborales actuales.
La equidad en una institución de educación superior ecuatoriana.
Authors: Zea Vera Mónica Elizabeth , D’Armas Regnault Mayra José
Published: July 2020

La investigación desarrollada tuvo como objetivo determinar la percepción sobre el ejercicio efectivo de los principios de equidad de todos los actores de una institución de educación superior ecuatoriana, a partir del diseño y aplicación de un instrumento de medición confiable y válido. El instrumento se diseñó a partir de la revisión de literatura, y considera cuatro dimensiones: creencias personales, acceso y permanencia igualitarios, trato no discriminatorio, y medidas afirmativas de la institución. Se aplicó a una muestra de 136 miembros de la comunidad universitaria seleccionados mediante un muestreo casual. Los resultados sugieren una percepción positiva generalizada en la comunidad universitaria sobre el ejercicio de la equidad en la institución, evaluado por los encuestados mediante una escala tipo Likert.
La educación técnica y tecnológica: una mirada actual sobre una formación relegada.
Authors: Piedra Martínez Ana Beatriz , Ochoa Calderón Verónica Maribel , Aguirre Vicuña María Gabriela
Published: July 2020

Hoy en día la educación técnica y tecnológica constituye una de las modalidades educativas con más problemas en el Ecuador; esto debido a que han sido escasos los esfuerzos en profundizar acerca del tema para entender que se trata de una modalidad con características y requerimientos propios. Este trabajo pretende dar cuenta de estas particularidades realizando un repaso histórico de la situación en el país y discutiendo sobre los desafíos que plantea este tipo de formación. A partir del análisis de la experiencia docente en el Instituto Superior Tecnológico del Azuay, entre estos destacan fenómenos como el desprestigio y la marginalización.
La utopía de la educación desde los documentos y organismos internacionales.
Authors: Trejo Chamorro Héctor Medardo
Published: July 2020

El artículo se enfoca en la revisión de los documentos, foros, declaraciones y tratados internacionales publicados por la UNESCO y otras organizaciones internacionales. Es un protocolo teórico que sustenta el trabajo de investigación doctoral en su primera fase, referido a “Concepciones y enfoques de la educación en ámbitos de educación superior”. El análisis se hace a partir de tres aspectos claves: revisión de los documentos que abordan el tema de la educación y sus políticas, comprensión de las utopías de la educación, y proyección de algunas ideas sobre la propuesta de replantear la educación desde las visiones de los organismos internacionales.
Comportamiento del docente ante la presencia del consumo de drogas en el entorno universitario.
Authors: Rodríguez Orozco Cinthya Lucía , Muñiz Granoble Gloria Janeth , Olaya Pincay María Elena , Sánchez Hernández Carmen Alexandra
Published: July 2020

La existencia del consumo de drogas en el entorno universitario es una problemática que va en crecimiento y es difícil de abordar por tal razón los docentes no logran identificar las señales de alerta del consumo dentro del contexto universitario. El objetivo fue determinar el comportamiento de los docentes ante la presencia del consumo de drogas en la comunidad estudiantil, estudio etnográfico, se obtuvo como resultados tres grandes categorías concluyendo que se evidencia al catedrático con una posición distante de la problemática planteada, negándose a un posible involucramiento en el tema desde el punto de vista asistencial además reconocen que el acompañamiento deficiente de los familiares en el entorno de los estudiantes interfiere en el comportamiento del alumno.
Intervención con ejercicio físico en estudiantes universitarios con síndrome de burnout: un protocolo de estudio.
Authors: Rosales Ricardo Yury
Published: July 2020

El Síndrome de Burnout representa un problema social y de salud en los estudiantes universitarios. Se describe el protocolo de estudio de una intervención con ejercicio físico en estudiantes universitarios con síndrome de burnout. El objetivo principal es determinar la efectividad de los ejercicios físicos en la disminución de los niveles de síndrome de burnout en estudiantes universitarios del Ecuador. Si la intervención se comprueba que es eficaz, esto sugeriría que existe una intervención simple, económica y accesible estrategia para reducir el Síndrome de Burnout en esta importante y numerosa población estudiantil universitaria.
Análisis del gobierno electrónico de Ecuador utilizado como herramienta para transparentar la gestión pública y participación ciudadana.
Authors: Ripalda Yánez Juan Félix
Published: July 2020

El avance e innovación de las Tecnologías de Información y comunicación ha obligado a los Estados, a reformular sus acciones, estableciendo políticas gubernamentales enmarcadas en la Modernización, contempladas en planes elaborados con la finalidad de informar la gestión pública con transparencia, y a la vez, que la ciudadanía participe de este mecanismo, mediante la entrega de los servicios en línea, aprovechando precisamente las plataformas digitales, buscando simplificar los trámites, ahorrando tiempo y dinero, performance que ha funcionado a plenitud en muchos países que apostaron a la era digital con excelentes resultados. Ecuador, forma parte del Gobierno electrónico, política aplicada desde sus inicios por la Secretaría Nacional de la Administración Pública, ente que estaba a cargo de implementar, regular y asesorar.
Evaluación de ataques DDoS y fuerza bruta utilizando entorno virtual Kali Linux como plataforma experimental.
Authors: Rivera Osorio Edgar Fabricio , Cárdenas Zea Miriam Patricia , Chiriboga Casanova Washington Alberto
Published: July 2020

La investigación se enfoca en la evaluación de ataques de denegación de servicios tipo SYN Flood y ataques de fuerza bruta, utilizando como plataforma de experimentación un entorno virtual de red que permita identificar cómo actúan dichos ataques en la saturación del ancho de banda y descubrir la contraseña del usuario administrador para poder ingresar a un sitio web con fines maliciosos. Para validar está investigación se desarrolló un mecanismo de detección y mitigación de los ataques en los hosts víctimas, a nivel de la capa de Internet del modelo TCP/IP con la formulación de reglas a nivel del firewall Iptables en Linux Centos 6.7.