bluuebunny/crossref_metadata_2025 huggingface dataset:
The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases
Authors: Jung Manfred , Roatsch Martin , Hoffmann Inga , Abboud Martine I. , Hancock Rebecca L. , Tarhonskaya Hanna , Hsu Kuo-Feng , Wilkins Sarah E. , Yeh Tzu-lan , Lippl Kerstin , Serrer Kerstin , Moneke Isabelle , Ahrens Theresa D. , Robaa Dina , Wenzler Sandra , Franz Henriette , Sippl Wolfgang , Lassmann Silke , Diederichs Sven , Schleicher Erik , Schofield Christopher J. , Kawamura Akane , Schüle Roland
Published: July 2019

Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are epigenetic eraser enzymes involved in the regulation of gene expression and are emerging drug targets in oncology. We screened a set of clinically used iron chelators and report that they potently inhibit JMJD2A (KDM4A) in vitro. Mode of action investigations revealed that one compound, deferasirox, is a bona fide active site-binding inhibitor as shown by kinetic and spectroscopic studies. Synthesis of derivatives with improved cell permeability resulted in significant upregulation of histone trimethylation and potent cancer cell growth inhibition. Deferasirox was also found to similarly inhibit human 2OG-dependent hypoxia inducible factor prolyl hydroxylase activity. Therapeutic effects of clinically used deferasirox may thus involve transcriptional regulation through 2OG oxygenase inhibition. Deferasirox may provide a useful starting point for the development of novel anticancer drugs targeting 2OG oxygenases and a valuable tool compound for investigations of KDM function.
Energy Conservation via Thioesters in a Non-Enzymatic Metabolism-like Reaction Network
Authors: Chevallot-Beroux Elodie , Gorges Jan , Moran Joseph
Published: July 2019

Life’s catabolic processes capture chemical energy from the oxidative breakdown of metabolites. In the catabolic pathways at the core of biochemistry, the oxidation of α-ketoacids or aldehydes is coupled to the synthesis of thioesters, whose energy-releasing hydrolysis is in turn coupled to the production of adenosine 5’-triphosphate (ATP). How these processes became linked before life emerged, and thus how the framework for modern bioenergetics was established, is a major problem for understanding the origins of biochemistry. The structure of biochemical networks suggests that the intermediary role of thioesters in biological energy flows, and their central role in biosynthesis, is a consequence of their entry into metabolism at the earliest stage of biochemical evolution. However, how thioesters could have become embedded within a metabolic network before the advent of enzymes remains unclear. Here we demonstrate non-enzymatic oxidant- or light-driven thioester synthesis from biological α-ketoacids and show it can be integrated within an iron-promoted metabolism-like reaction network. The thioesters obtained are those predicted to be pivotal in computational reconstructions of primitive biochemical networks (acetyl, malonyl, malyl and succinyl thioesters), demonstrating a rare convergence between top-down and bottom-up approaches to the origins of metabolism. The diversity and simplicity of conditions that form thioesters from core metabolites suggests the energetic link between thioester synthesis and catabolism was in place at the earliest stage of prebiotic chemistry, constraining the path for the later evolution of life’s phosphorus-based energy currencies.
Identifikasi Daging Sapi Segar Dan Beku Menggunakan Learning Vector Quantization
Authors: Cahyono Lilis , Supatman Supatman
Published: July 2019

Di Indonesia harga daging sapi cukup mahal, hal ini terjadi karena mata rantai distribusi yang sangat panjang dari peternak hingga ke tangan konsumen, sehingga diperlukan biaya yang sangat tinggi untuk membeli daging sapi. Dengan mahalnya daging sapi tersebut ada beberapa oknum yang berusaha mencampur kualitas kesegaran daging sapi dengan mencampurnya antara daging yang baru dipotong dengan daging yang sudah dipotong beberapa waktu. Kondisi ini sangat merugikan konsumen yang membeli daging sapi. Saat ini identifikasi daging dilakukan secara kasat mata maupun dengan menekan dagingnya untuk mengetahui tekstur daging. Cara ini memiliki banyak kelemahan bila para konsumen tidak jeli untuk membedakan kualitas kesegaran daging sapi. Perkembangan ilmu pengetahuan dan teknologi pengolahan citra digital memungkinkan untuk memilih kualitas kesegaran daging sapi tersebut secara otomatis dengan bantuan aplikasi pengolahan citra. Tujuan dari penelitian ini adalah mengembangkan algoritma untuk mengidentifikasi daging sapi segar dan sapi beku menggunakan Learning VectorQuantization (LVQ). Jumlah data pelatihan yang digunakan terdiri dari 2 kelas (kelas 1 : kelas daging segar dan kelas 2 : daging sapi beku), masing-masing kelas berjumlah 15 data pelatihan, jadi total data berjumlah 30 data pelatihan. Sedangkan untuk data uji masing-masing kelas menggunakan 20 data uji dengan total berjumlah 40 data uji. Pada proses pelatihan menggunakan Learning Vector Quantization diperoleh unjuk kerja identifikasi terbaik sebesar 96,67% pada parameter dec alfa (decα) 0,75 dengan alfa (α) 0,00001. Bobot akhir yang diperoleh dari hasil learning tersebut kemudian digunakan untuk melakukan pengenalan data uji. Unjuk kerja terbaik pengujian dengan presentase komulatif mencapai 80% yaitu data mengenali daging segar 12 pada kelas 1 dan data mengenali daging sapi beku 20 pada kelas 2.
Pożegnanie z mistrzem
Authors: Bojarski Wacław
Published: July 2019

A fragment of Wacław Bojarski’s short story “Pożegnanie z mistrzem” [Farewell to the Master], published under the penname of “Jan Marzec” in the underground periodical Sztuka i Naród (1943, nos 9–10). The story, which is an attempt to imitate Schulz’s style, is an interesting trace of his reception in the Polish patriotic-nationalist discourse.
Els versos dels calaixos
Authors: Mira-Navarro Irene Mira-Navarro
Published: July 2019

Aquest any 2018 els estudis literaris al voltant de la poesia de Vicent Andrés Estellés estan d’enhorabona. El 25é aniversari de la mort del poeta s’ha commemorat, casualment o no, amb l’edició del 5é volum de l’Obra Completa Revisada i l’obra que ací ressenyem, entre altres articles científics.

Ferran Carbó, catedràtic de Filologia Catalana a la Universitat de València, és una de les veus cabdals en l’estudi de la poesia catalana del segle xx. Així ho avalen les publicacions realitzades sobre Joan Vinyoli, Miquel Martí i Pol i Vicent Andrés Estellés al llarg de la seua trajectòria. La coherència investigadora d’aquest autor es materialitza en un ingent nombre de textos acadèmics sobre la matèria, obres monogràfiques dedicades a Joan Vinyoli i l’imprescindible Com un vers mai no escrit. La poesia de Vicent Andrés Estellés en els anys cinquanta (2009).
“Vosaltres, dones”: sant Vicent Ferrer i l’auditori femení dels sermons
Authors: Arronis Llopis Carme
Published: July 2019

Aquesta reflexió pretén subratllar l’afany amb què sant Vicent Ferrer predicava a les dones del seu auditori. Si bé els sermons del dominic reflecteixen el pensament misògin medieval sobre la concepció de la dona, sobre els seus costums i sobre els ideals que havien d’imitar, permeten alhora veure la seua presència constant en els diversos àmbits de la societat. Sant Vicent, mitjançant diversos recursos, fa que les dones siguen ben presents i visibles en cada prèdica: no hi ha, per al sant valencià, possibilitat de redreçament social que no comporte la implicació de les dones.
Aplicación del algoritmo k-means como técnica de minería de datos para determinar el nivel de autoestima en los alumnos universitarios mediante la escala de Rosenberg
Authors: Núñez Cárdenas Felipe de Jesús , Hernández Reyes Juan Fernando , Felipe Redondo Ana María , Tomás Mariano Víctor Tomás
Published: July 2019

En el presente trabajo se realiza una tipificación aplicando técnicas de minería de datos sobre el tema de la autoestima en alumnos universitarios de la carrera de Ciencias Computacionales, como herramienta de evaluación se aplico la escala de Rosenberg, así también mediante el algoritmo K-Means se realizo la agrupación de los datos y como resultado se busca obtener tres clusters, ya que la herramienta de evaluación diagnostica tres tipos de autoestima.
inconstitucionalidade por omissão
Authors: Bomfim Rainer , Bahia Alexandre Gustavo Melo Franco
Published: July 2019

Analisa a ordem jurídica internacional dos direitos humanos, particularmente, no nível interamericano para ver a possibilidade do ajuizamento, junto à Comissão Interamericana de Direitos Humanos, de denúncia de demora injustificada na criminalização da LGBTIfobia por parte do Estado Brasileiro, uma vez que o Brasil é signatário de diversos tratados e acordos internacionais que obrigam este a legislar e coibir formas de LGBTIfobia no território nacional. Além disso, a Constituição da República de 1988, que inaugura o Estado Democrático de Direito, preconiza pelo Direito fundamental da Igualdade e da não-discriminação por parte do Estado. Parte-se da hipótese de que o Brasil se encontra em mora que viola a Constituição e Normas Internacionais de Direitos Humanos, o que ensejou o ajuizamento da ADO. n. 26 e do MI. n. 4733, ambos pedindo ao STF que reconheça a omissão inconstitucional do Brasil a respeito. Ambas ações tiveram seu julgamento iniciado em fevereiro de 2019 e, por hora, tiveram quatro votos favoráveis. A metodologia utilizada no trabalho é a jurídico-sociológica.
PENGARUH PERBEDAAN WAKTU PAJAN TERHADAP JUMLAH BAKTERI Salmonella sp. DAN Shigella sp. PADA JAJANAN PEDAGANG KAKI LIMA DI LINGKUNGAN KAMPUS 1 UNIVERSITAS MUHAMMADIYAH PURWOKERTO
Authors: Setiawati Yulis , Purbowati Mustika Ratnaningsih , Ulfa Maria
Published: July 2019

Latar belakang: Foodborne disease merupakan penyakit yang ditimbulkan oleh makanan yang terkontaminasi oleh bakteri. Data BPOM RI (2015) menyebutkan di Indonesia pada tahun 2014 didapatkan data Kejadian Luar Biasa (KLB) akibat keracunan pangan dimana Salmonella sp. dan Shigella sp. merupakan bakteri patogen terbanyak penyebab keracunan makanan dan penyebab kematian. Data BPOM RI (2017) periode bulan januari-maret 2017 mengungkapkan bahwa penyebab keracunan pangan di Indonesia masih didominasi oleh Pedagang Kaki Lima (PKL). Pertumbuhan dan kematian bakteri di dalam bahan makanan salah satunya dipengaruhi oleh waktu dan suhu. Waktu dan suhu merupakan parameter kritis untuk menilai laju pertumbuhan mikroorganisme. Identifikasi bakteri dengan menumbuhkan pada media selektif dapat dilakukan untuk mengetahui apakah jajanan tersebut terkontaminasi bakteri Salmonella sp. dan Shigella sp.  Tujuan: Mengetahui pengaruh perbedaan waktu pajan terhadap jumlah bakteri Salmonella sp. dan Shigella sp. pada jajanan pedagang kaki lima di lingkungan kampus I Universitas Muhammadiyah Purwokerto. Metode: Penelitian non experimental analitik observasional dengan rancangan cross-sectional  yang melibatkan 34 sampel jajanan, analisa uji T berpasangan. Hasil: Tidak ditemukan koloni Salmonella sp. pada jajanan dengan waktu pajan ≤ 2 jam sedangkan Shigella sp. ditemukan total koloni 17 CFU/ml. Total koloni Salmonella sp. dengan waktu pajan > 2 jam adalah 72 CFU/ml dan total koloni Shigella sp. adalah 96 CFU/ml. Kesimpulan: Tidak terdapat pengaruh perbedaan (P > 0.05) waktu pajan terhadap jumlah bakteri Salmonella sp. dan Shigella sp. (P value – 0.62 ) pada jajanan pedagang kaki lima di lingkungan kampus 1 Universitas Muhammadiyah Purwokerto. 1 sampel positif Salmonella sp. dengan jumlah koloni 52 CFU/ml dan 2 sampel positif Shigella sp. dengan jumlah koloni 76 CFU/ml dan 10 CFU/ml, jumlah tersebut diatas batas aman dan dapat menimbulkan risiko penularan penyakit lewat makanan apabila terkonsumsi oleh manusia.
Pengaruh Program Makan Siang terhadap Asupan Makanan, Status Anemia dan Perilaku Gizi Santri Perempuan
Authors: Kusumawati Dewi , Rimbawan Rimbawan , Ekayanti Ikue
Published: July 2019

Penyediaan makanan di asrama pada umumnya terbatas karena masalah biaya sehingga siswa rawan terjadi kekurangan gizi. Kekurangan zat besi pada remaja dapat menimbulkan anemia. Penelitian ini bertujuan untuk mengevaluasi pengaruh program makan siang terhadap asupan makanan, status anemia dan perilaku gizi pada santri perempuan di Pondok Pesantren Darusalam Bogor. Penelitian ini adalah pre eksperimen dengan desain one group pre post intervention. Subjek yang terpilih sebanyak 54 siswa diberikan intervensi penambahan protein dan buah pada makan siang serta pendidikan gizi selama 15 minggu. Pendidikan gizi disampaikan oleh guru dan penyegaran materi dilakukan oleh mahasiswa gizi. Hasil penelitian menunjukkan energi, protein, lemak, karbohidrat, serat, kalsium, seng, zat besi dan Vitamin C mengalami peningkatan pada asupan makan siang dan berbeda signifikan dengan sebelum intervensi (p<0,05). Status gizi (IMT/U) mengalami peningkatan dan signifikan berbeda antara sebelum dan sesudah intervensi (p<0,05). Proporsi status anemia mengalami perbaikan menjadi lebih baik dan signifikan berbeda setelah intervensi namun peningkatan kadar hemoglobin sebesar 0,14±1.12 g/dl belum mampu memberikan perbedaan rata-rata kadar hemoglobin yang signifikan (p>0,05). Pengetahuan dan sikap gizi santri tentang anemia signifikan berbeda antara sebelum dan setelah intervensi (p<0,05).
The Comparison of Ostecyte in the Pressure area and Tension area on Tooth Movement Because of Hyperbaric Oxygen Therapy
Authors: Barahmanta Arya , Winaris Muhammad Faizal , Raharjo Pambudi
Published: July 2019

Background: Orthodontic tooth movement is a interaction prosess of resorption and deposition of bone remodeling. Orthodontic tooth movement by mechanical strength causes changes in alveolar bone. Osteocyte is an essential cell to respond bone remodelling. Hyperbaric Oxygen Therapy affects production of osteocyte because it can release Reactive Oxygen Species (ROS) and Nitrid Oxide (NO).  Purpose: To determine the difference number  of osteocyte in pressure and tension area during tooth movement by adjuvant of Hyperbaric Oxygen 2,4 ATA during 7 days starting on day 8 to day 14. Materials and Methods: This research used Completery Randomized Control Group Post Test Only Design. 36 cavia cobaya (male)  were divided into 3 groups randomly : the negative control groups, positive control group, and treatment group. Preparat staining used Hematoxylin Eosin (HE) and calculated on microscop 1000x with 20 field of view. Data analyses used one way ANOVA and LSD test then compared each area by using paired T test. Result: The data showed that the treatment group (P=10,67) tension area has the highest number of osteocyte than  negative control group (K-=3,67), positive control (K+=7,42). In the pressure area showed that negative control group (K-=5,00) has the highest  than positive control group (K+=3,83) and treatment (P=3,25). Conclusion: Therapy HBO 2,4 ATA 7 days starting on day 8 to day 14 is could increase osteocyte in the tissue to stimulate process of bone remodelling.
 
Keywords: Hyperbaric Oxygen, Tooth movement, Bone remodeling, Osteocyte

 

Correspondence: Arya Brahmanta, Department of Orthodonty, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, Email: arya.brahmanta@hangtuah.ac.id
RENCANA AKSI PENGEMBANGAN AGROINDUSTRI KABUPATEN BONDOWOSO
Authors: Hermawati Diah Tri
Published: July 2019

ABSTRAKPenelitian ini dengan Judul Rencana Aksi Pengembangan Agroindustri Kabupaten Bondowoso dengan tujuan memberikan arahan pengembangan agroindustri secara menyeluruh terhadap pembangunan ekonomi di Kabupaten Bondowoso.Metode yang digunakan adalah metode Analisis Deskriptif. Analisis Tipologi Klassen dan Location Quotient (LQ), Analisis Matriks IFE dan EFE Selanjutnya,  dilakukan  analisis  Matrik  SWOT  untuk  mengetahui kekuatan, kelemahan, peluang dan ancaman yang melekat dalam upaya pengembangan agroindustry, Analitycal Hierarchy Process (AHP) dan Analisis manajemen strategis.Hasil Penelitian Rencana Aksi Pengembangan Agroindustri diantaranya yaitu: Klaster Kopi Rakyat dan Padi Organik telah terbentuk di Kabupaten Bondowoso. Teknologi tepat guna yang dibutuhkan bagi pengembangan agroindustri di Kabupaten Bondowoso adalah teknologi yang sesuai dengan skala UKM (agroindustri rakyat) yang dapat dikembangkan lebih besar di masa depan dan dapat bekerjasama dengan perusahaan besar atau eksportir. Belum terdapat lembaga pemasaran khusus produk agroindustri baik dari inisiatif pemerintah maupun swasta. Akses permodalan bagi UKM masih lemah dan masih membutuhkan fasilitasi dan dukungan regulasi dari pemerintah daerah maupun provinsi. Klaster agroindustri bambu merupakan prioritas untuk disiapkan pada tahun 2016 dan dimantapkan dalam periode 2016-2020. Koordinasi dan sinkronisasi program agroindustri antar SKPD masih perlu ditingkatkan dengan membentuk Kelompok Kerja (Pokja) khusus agroindustri, sehingga dapat memberikan arah kebijakan dan program yang lebih jelas bagi semua pemangku kepentingan.Kata kunci : Agroindustri, Produk Unggulan, UKM.
Perencanaan dan Penganggaran yang Responsif Gender di Kabupaten Gresik
Authors: Koesriwulandari Koesriwulandari
Published: July 2019

ABSTRAKPenelitian ini dengan judul Perencanaan dan Penganggaran yang Responsif Gender di Kabupaten Gresik. Bertujuan untuk mewujudkan pembangunan yang menjamin kesetaraan bagi perempuan dan laki-laki dalam aspek akses, partisipasi, kontrol dan manfaat pem-bangunan di Kabupaten Gresik.Dalam pelaksanaan penelitian ini metode yang digunakan yaitu dilakukan pengumpulan data di wilayah administrasi Kabupaten Gresik dengan menggunakan subyek data yang paling dapat dipercaya (valid) dan terbarukan (update) yang dimiliki daerah bersangkutan.Hasil Penelitian ini menyimpulkan Kabupaten Gresik dalam pencapaian seluruh indikator pada goals ini (terdapat 10 indikator) menunjukkan prestasi sebesar 63,33%. Dengan perincian status capaian: 4 indikator (40%) menunjukkan status capaian “telah mencapai target”; 3 indikator (30%) menunjukkan status “menuju arah pencapaian target”; dan 2 indikator (20%) dengan status capaian “masih jauh dari arah pencapaian target”; sedangkan 1 indikator belum diketahui status capaiannya karena sampai laporan ini disusun belum tersedia data untuk itu; Hal ini menjadi “pekerjaan rumah” untuk segera menyelenggarakan bimbingan teknis, mengingat Kabupaten Gresik telah mengesahkan perda tentang pengarus utamaan gender, terlebih lagi, berdasarkan penelurusan (dari hasil wawancara dan isian kuesioner) di Kabupaten Gresik terdapat beberapa pejabat (eselon III) yang telah mengikuti ToT (Training of Trainer) fasilitasi PPRG. Demikian kesimpulan penutup yang dapat disajikan pada penelitian tentang (kesiapan) penyusunan dokumen perencanaan pembangunan yang resposif gender di Kabupaten Gresik. Sangat disadari akan kekurangan hasil kajian kali ini, dari 25 SKPD yang menjadi target (sampel) penye-baran kuesioner tentang pemahaman aparatur pemerintah, hanya 11 SKPD dengan total responden sebanyak 82 orang (pejabat eselon III dan IV). Dan dari 20 SKPD yang menjadi sampel penyebaran kuesioner tantang kajian kebijakan, program dan kegiatan dalam pelaksanaan PUG dan PPRG, hanya 6 SKPD yang mengembalikan dan mengisi kuesioner dimaksud.Kata kunci : Responsif Gender, Kesetaraan, Pengarusutamaan Gender.
Seasonal variations of snowpack temperature and thermal conductivity of snow in the vicinity of Vostok station, Antarctica
Authors: Shibayev Yu. A. , Tchikhatchev K. B. , Lipenkov V. Ya. , Ekaykin A. A. , Lefebvre E. , Arnaud L. , Petit J.-R.
Published: July 2019

The data on snow the temperature which was monitored to a depth of 10 m in the vicinity of Vostok Station by the TAUTO autonomous system in 2010–2017 are presented. By analyzing seasonal temperature variations at different depth with the aid of a heat-transfer model we have inferred a relationship between relative thermal conductivity of snow and its porosity at this site. The same approach was also applied to analyze similar data obtained at Dome Fuji station in 1995–1997. It was found that the thermal conductivity of snow layers with identical density is noticeably lower at Dome Fuji than at Vostok, which point to a difference in structural characteristics of snow that determine its thermophysical properties. We demonstrate that the conduction is the dominant heat-transport mechanism which controls the temperature distribution in snow pack on the Antarctic plateau. The obtained parameters of the heat-transfer model can be used for reconstructing the past surface temperature variations from the long-term temperature measurements in the upper 100 m thick layer of the ice sheet.
The Intrinsic Nature of Emergence—With Illustrations
Authors: Vesterby Vincent
Published: July 2019

George Henry Lewes introduced anthropomorphism into the emergence literature. This opened the way for attempts to define emergence with factors that are not relevant to its intrinsic nature. In this paper, the general context of emergence in the universe is presented, mainly in terms of general systems understanding. This is followed by a descriptive definition of the intrinsic nature of emergence, and a discussion of how the process of emergence changes due to the roles of various factors.Material-reality is composed of elementary particles organized into seemingly endless patterns-of-organization of material structure and process. The difference between the smaller or the simpler patterns and the larger or the more complex patterns is the quantity of elementary particles and the patterns-of-organization of those particles.Reality is that which exists. There is but one reality—all that exists. Reality develops, that is, everything that exists takes part in one way or another in a universally omnipresent transition, a sequential-difference from one time, place, part, pattern, level, condition, or situation to another involving some form of enhancement.Emergence is a type of development. Emergence is a general-factor, a process-pattern-of-organization that plays a universal role in the coming into existence of new pattern-of-material-organization as a consequence of motion. Emergence itself develops, occurring in simple form in situations where few factors are playing roles, and in more complex form in situations where more factors are playing roles. Some additional factors that result in the foundational developments of emergence are combinatorial-enhancement, contact, causal push, throughflow wherein the flow of energy reorganizes matter and blocking matter reorganizes the flow of energy, and coherent bonding of one part of matter with another. Emergence is intrinsically determinate in that, in the process of emergence, the existence and intrinsic qualities of what goes before determine the existence and intrinsic qualities of what follows. Both complexity and the hierarchic organization of material-reality are consequences of emergence.
Adolescent lifestyle in India: Prevalence of risk and health-promotive factors
Authors: Singh Arun Pratap
Published: July 2019

The present study investigated the prevalence of lifestyle related concerns among school adolescents. The data were collected from 1,500Indian school students enrolled in sixth to eleventh grades drawnfrom rural, urban, and metro settings. They completed an anonymousAdolescent Lifestyle Survey. The study documents the multiple concerns related to inappropriate dietary practices (fast food consumption,cold drinks, low fruit and vegetable intake), irregular sleeping habits,less religiosity, mild activity pattern, unhealthy daily routine and pursuance of different forms of risk behaviours. The study also showed anassociation of life style with several contextual variables (i.e., residentialcontext, developmental stage and gender). The results suggest needfor urgent attention to deal with the emerging concerns of risks andpromoting factors of health through relevant policy-oriented reformulation, coordinated efforts among stakeholders, and initiating culturallyappropriate lifestyle interventions among adolescents.
Model Pengembangan Modul Mata Kuliah Pembelajaran Sastra
Authors: Helaluddin
Published: July 2019

One of the most important thing in learning and studying process is the ability of material. In learning literature also, module is one of the material that should help the students in understanding the materials. Remembering how much important a module for students, there are many theories given the experts. Dick, Carey and Carey or Jolly and Bolitho are one of the example. To get the perfection, combinating two kinds of model is one of the solution. The steps in combinating these model is to identity the needs, design of module, production of module, validating experts, revision of module, and testing the module
Catatan Komposisi Kita
Authors: Bella Rahimia
Published: July 2019

Catatan Komposisi Kita karya Elsa Rosyidah dan Agung Purnomo
Administrasi layanan khusus
Authors: agustin julpia , Afriansyah Hade , Hadiyanto Hadiyanto
Published: July 2019

This article describe about special service administration
Implementation of Prototyping Method on Website Development of Land use Mapping
Authors: Sasmito Ginanjar Wiro
Published: July 2019

Increasing diversity of urban activity attracts many people to try their fate in urban areas so as to heighten the flow of urbanization. This resulted in a large demand for land supply to accommodate the increasing number of city dwellers. On the other hand, land is a very limited resource and cannot be created or renewed, so the problem that often arises is the proliferation of slum and squatter areas in urban areas. The solution to the problem is to produce a land use website. By using the prototyping method of land use website is generated in order to speed up the development of website and to really fit with the wishes and needs of the client
Core Neuropsychological Measures for Obesity and Diabetes Trials Project: Initial Report (Version 2)
Authors: d'Ardenne Kim , Savage Cary , Small Dana , Vainik Uku , Stoeckel Luke E.
Published: July 2019

The Core Neuropsychological Measures for Obesity and Diabetes Trials Project aimed to identify the key cognitive and perceptual domains in which performance can influence treatment outcomes, including predicting, mediating, and moderating treatment outcome and to generate neuropsychological batteries comprised of well-validated, easy-to-administer tests that best measure these key domains. The ultimate goal is to facilitate inclusion of neuropsychological measures in clinical studies and trials so that we can gather more information on potential mediators of obesity and diabetes treatment outcomes. We will present the rationale for the project and three options for the neuropsychological batteries to satisfy varying time and other administration constraints.
Motor simulation is disturbed when experiencing pain
Authors: Cracco Emiel , Clauwaert Amanda , Van den Broeck Yentl , Van Damme Stefaan , Brass Marcel
Published: July 2019

While the contributions of social processes to pain perception are well-documented, surprisingly little is known about the influence of pain on social perception. In particular, an important question is how pain modulates the processing of other people’s actions. To address this question, the current study tests, using automatic imitation, the hypothesis that pain interferes with motor simulation – that is, the processing of observed actions in the motor system. Participants in both experiments performed an automatic imitation task requiring them to abduct their index or little finger while they saw someone else performing a congruent or incongruent action. Automatic imitation was measured in a pain-free context, a context where pain was coupled to movement execution (Experiment 1), and a context where pain occurred randomly (Experiment 2). The results revealed that automatic imitation, indexed by slower responses on incongruent than on congruent trials, was reduced when experiencing pain, both when pain was linked to movement execution and when it was not. Thus, the current study shows that pain leads to reduced motor processing of others’ behavior, and as such has important implications for understanding the social difficulties associated with pain.
Pragmatic constraints do not prevent the co-activation of alternative names: Evidence from sequential naming tasks with one and two speakers
Authors: Mädebach Andreas , Kurtz Franziska , Schriefers Herbert , Jescheniak Jörg D.
Published: July 2019

We investigated whether the phonological co-activation of alternative names in picture naming (e.g. "fish" for target "shark") is reduced by contextual constraints which render them inappropriate. In the constraining context, the target naming response was preceded by a naming response to an object from the same category (e.g., an eel) which remained visible during target naming. Therefore, use of the alternative target name "fish" would result (a) in an ambiguous response because of the visual context and (b) in a pragmatically odd response because of the previous naming response. In Experiment 1 the context pictures were named by the participants themselves and in Experiment 2 by a communication partner. In both experiments, interference from distractor words phonologically related ("finger") versus unrelated ("book") to the alternative name was observed regardless of context. This finding indicates limited flexibility in lexical activation during speech planning.
Will this time be different?
Authors: Srivastava Sanjay
Published: July 2019

Prepared remarks delivered to the Society for the Improvement of Psychological Science on July 9, 2019 in Rotterdam.
Public Investment: Some Measuring Instruments
Authors: Sharma Sharad
Published: July 2019

Not available.Key words: Investment decisions; Scarcity of resources; Economy; NepalTribhuvan University Journal Vol XXI, No. 2, 1998 Page: 35-46 Uploaded date: 22 April, 2011
Dangaura TharukaChad Parva: ek Simhabalokan
Authors: Subedi Rajaram , Tharu Ashok
Published: July 2019

Not Available.TU Journal, Vol. 26, No. 1, September 2009 Page:153-168
Strategi Imitasi dan Perilaku Konsumen Rokok Country
Authors: Albar Berri Brilliant
Published: July 2019

This research is purposed to analyze the factors which influence the consumers in purchasing imitate product. In this case refer to Country cigarettes that success in national market because its appearance features tend look like Marlboro cigarettes. Consumer behavior influenced by marketing stimuli from the marketer of imitation product including the product that look a like the market lader, close packaging feature with market leader do, the same distribution strategy with market leader. Beside all of that factors, it is also influenced by attitude, referring group, and life style that comes from the customers.

The research population is the Country cigarrettes’s consumers in Andalas University which know about Marlboro and the sample was taken with simple random sampling method of population. The responden are 100 persons. Research analysis data using double regression analysis technique. After all data is collected then it processed with SPSS (Statistical Package for the Social Sciences) program in case to be examined statistical by doing the statistical test.

The result of research shows that same packaging with market leader do not have any positive influence and significant to wants in buying, meanwhile attitude variable have negative influence to wants to repeating buying. But, product that look a like the market leader, cheaper price, same promotion with market leader and same distribution strategy with market leader have positive influences and significant to wants of consumer to repeat buying the product.

 

Key words: imitation, consumer behavior
Sadomasochistic erotica and the sexual response cycle: Insights from the Eunuch Archives
Authors: Piccolo Elisabetta E. L. , Johnson Thomas W. , Wassersug Richard J.
Published: July 2019

The Eunuch Archive (EA) is a website where registered members can post for others to read and rate sexual fantasies that involve genital mutilation and ablation. The EA includes over 8,000 stories. We have previously explored common features of 100 top-rated EA stories. We reasoned that understanding such fantasies may be a step toward recognizing who is at risk of irreversible injury should they act out their fantasies. Here we explore the top-rated EA stories in the context of well-established models for human sexual response. We argue the archetypal storyline from these fantasies, which are characterized by extreme sadomasochism (SM), can be interpreted and understood within the context of these established sexual response models, but we note several ways the fantasies diverge from such models. The stories closely fit the classic Masters and Johnson model, but with a protracted plateau phase resolved with pleasure and pain heightened. Even though the central character in all the stories is a male, the stories align well with the Basson intimacy-based model more characteristic of female motivations to be sexually active. In the fantasies, the central character is willing to sacrifice everything short of his life to develop or strengthen a dyadic relationship. In all the stories, castration is depicted with a sensory intensity equivalent to orgasm. The stories reveal what is both natural and pathological in extreme SM fantasies. They also reveal similarities between female sexual desire and the desire for genital ablation which has not, to the best of our knowledge, been previously elucidated.
THE APPLICATION FEATURES OF DIRECTIONAL BHAS WHILE DRILLING DIRECTIONAL WELLS
Authors: Chudyk I.I. , Livinskyi A.M. , Al Tanakchi Akhmed , Pastuch A.M.
Published: July 2019

The article presents a scientific and practical approach to assessing the energy efficiency of directional bottom hole assembly on the basis of the mud motor. The main design feature of these assemblies is the presence of a bent angle in the spindle section of the mud motor. The conditions of operation of such assemblies are considered for a combined drilling method with a various number of stabilizers. Particular attention is paid to determining the causes of unproductive energy costs on the work of the directional bottomhole assemblies in the borehole.The mathematical model improved by the authors includes the geometric features of the assembly design, the bent angle of the spindle of the mud motor as to its body, the number of the stabilizers and the location of their installation, the borehole inclination angle, the physical and mechanical characteristics of the subsurface rock that forms it. The authors calculated the energy consumption for rotation and the axial displacement of the assemblies in the directional well taking into account the deflection forces on the bit and the reaction on the stabilizers. The researchers suggest the use of the indicator of specific energy costs to overcome the forces and moments of the environment resistance during the work of the directional assemblies using the method of combined drilling.Using the results of analytical research and the developed approach the authors study energy costs for thework of the directional bottom hole assemblies with a various number of the stabilizers. The study is conducted for the slick assemblies, as well as for assemblies with one- and two-stabilizers. It is established that directional assemblies with one stabilizer are characterized by the highest values of the forces of resistance of axial displacement and rotation in the directional well. As they are high-torque, energy-consuming and the most energy-intensive systems, their practical use is limited. The main factors in the formation of energy costs for the work of directional assemblies while applying the combined drilling method are the number of the stabilizers and the inclination range.
•	THE INFLUENCE OF CARBONIC ACID AMMONIUM SALTS ON THE FILTRATION PROPERTIES OF BOTTOM-HOLE FORMATION ZONE
Authors: Dmytrenko V. I. , Zezekalo I. H.
Published: July 2019

The possibility of using ammonium carbonates to increase hydrocarbons extraction is considered. To study the effect of ammonium carbonate salts on the reservoir filtration properties a complex of experimental studies has been carried out. It has been established that carbon dioxide ammonium salts, in the absence of calcium chloride water, interact with carbonate rocks, increase the absolute permeability of reservoirs. The solutions of ammonium carbonate salts interact with calcium chloride type of formation water and form chemically precipitated chalk in the pores of the rock. Herewith the permeability of carbonate rocks decreases.
The industrial tests of ammonium carbonate salts have shown an increase in gas flow rate by 30-50% at wells № 23 of Opishnyanske, № 115 of Mashivske, № 3 of Tymofiyivske gas condensate fields. The effect of the ammonium carbonates treatment of the formation is stipulated by the purification of the bottom-hole formation zone and an increase of the absolute permeability of the reservoirs. The increase of the condensation factor by 22-35% has been observed in wells № 56, 108 of Yablunivske and № 58 of Tymofiyivske gas condensate fields. The efficiency of the treatment is related to the simultaneous purification of the bottom-hole zone from asphalt-resinous contaminants and to the absolute permeability increase, as well as to the pore space hydrophilization and the increase in the mobility of condensate that has fallen due to the influence of carbon dioxide which generates as a result of the decomposition of carbonic acid ammonium salts. Thus, pilot tests at Opishnyanske, Mashivske, Tymofiyivske, Yablunsvske gas condensate fields of Poltava region confirmed the effectiveness of using ammonium carbonate salts to increase hydrocarbon production.
The prospect of further research is aimed at developing a technology for increasing the liquid hydrocarbons production by the use of ammonium carbonate salts.
Accuracy of Glucose Meter Among Adults in a Semi-urban Area in Kathmandu, Nepal
Authors: Pokhrel Asmita , Silvanus Vinutha , Pokhrel Buddhi Raj , Baral Binaya , Khanal Madhav , Gyawali Prajwal , Pokhrel Laxman , Regmi Deepak
Published: July 2019

Introduction: Glucose meters are gaining popularity in monitoring of blood glucose at household levels and in health care set-ups due to their portability, affordability and convenience of use over the laboratory based reference methods. Still they are not free of limitations. Operator’s technique, extreme temperatures, humidity, patients’ medication, hematocrit values can affect the reliability of glucose meter results. Hence, the accuracy of glucose meter has been the topic of concern since years. Therefore, present study aims to evaluate the analytical and clinical accuracy of glucose meter using International Organization for Standardization 15197 guideline.

Methods: A community based descriptive cross-sectional study was conducted in Kapan, Kathmandu, Nepal in April 2018. Glucose levels were measured using glucose meter and reference laboratory method simultaneously among 203 adults ≥20 years, after an overnight fasting and two hours of ingestion of 75 grams glucose. Modified Bland-Altman plots were created by incorporating ISO 15197 guidelines to check the analytical accuracy and Park error grid was used to evaluate the clinical accuracy of the device.

Results: Modified Bland-Altman plots showed>95% of the test results were beyond the acceptable analytical criteria of ISO 15197:2003 and 2013. Park Error Grid-Analysis showed 99% of the data within zones A and B of the consensus error grid.

Conclusions: Glucose meter readings were within clinically acceptable parameters despite discrepancies on analytical merit. Possible sources of interferences must be avoided during the measurement to minimize the disparities and the values should be interpreted with caution.
Calvarial Tuberculosis: A Diagnostic Quandary: A Case Report
Authors: Homagain Sushan , Shrestha Suraj , Sah Sushil , Sedain Gopal
Published: July 2019

Primary Calvarial Tuberculosis, a rare entity of skull is even rarer after second decade of life in a healthy person without evidence of tuberculosis elsewhere in the body. Most of the cases are often misdiagnosed as osteomyelitis/syphilis/bony metastasis.

We report a case of primary skull tuberculosis in 26-year-old male with complains of headache and swelling in the right frontal region with no history of previous tuberculosis. The patient was operated and the histopathological examination of excised tissue was suggestive of tubercular pathology. The patient is doing well after anti-tubercular therapy.

Being a rare disease, tubercular osteomyelitis of skull bones is often missed and misdiagnosed due to lack of clinical suspicion and slow growth of mycobacterium cultures. Histopathological examination of biopsy material and demonstration of acid-fast bacilli in the pus are helpful for diagnosis and early management of the disease.
The role of water in volcanism
Authors: Arsanova G. I.
Published: July 2019

Water plays an extremely important role in volcanism: it acts as an evacuator of viscous melts in a variety of ways, which is ensured by the presence of relevant properties of its phase states, which successively changing with the fall of the environmental parameters. In this sense, the supercritical (fluid) state of water is especially significant. The paper provides a summary of fluid properties that are unique in many ways. The properties determine the relationship between water fluid and silicate melt, which in turn explains the cause of volcanic phenomena and the course of eruptions: explosions of different power, the emergence of the so-called fluidized mass, scorching clouds, landslides and breakthroughs on the slopes, the formation of ignimbrites, as well as the mechanism of gas transport to the foot of volcanoes.

Both by role and quantity, water is the main volcanic substance, which together with the silicate melt constitutes magma.
Tracking APTs in industrial ecosystems: A proof of concept
Authors: Rubio Juan E. , Roman Rodrigo , Alcaraz Cristina , Zhang Yan
Published: July 2019

In recent years, Advanced Persistent Threats (APTs) have become a major issue for critical infrastructures that are increasingly integrating modern IT technologies. This requires the development of advanced cyber-security services that can holistically detect and trace these attacks, beyond traditional solutions. In this sense, Opinion Dynamics has been proven as an effective solution, as they can locate the most affected areas within the industrial network. With this information, it is possible to put in place accurate response techniques to limit the impact of attacks on the infrastructure. In this paper, we analyze the applicability of Opinion Dynamics to trace an APT throughout its entire life cycle, by correlating different anomalies over time and accounting for the persistence of threats and the criticality of resources. Moreover, we run various experiments with this novel technique over a testbed that models a real control system, thereby assessing its effectiveness in an actual industrial scenario.
PELUANG PAY TV MENGGESER DOMINASI FREE TO AIR TV DI PERKOTAAN
Authors: Setyobudi Ciptono , Sjailendra Sjailendra
Published: July 2019

Perkembangan perkotaan yang pesat dengan pembangunan fisik berupa gedung bertingkat baik berupa hotel, perkantoran maupun apartemen akhir-akhir ini berakibat juga terhadap perambatan gelombang radio diudara bebas .Media televisi terestrial tidak berbayar ( free to air ) yang menggunakangelombang radio jalur Ultra High Frequency (UHF), pada frekuensi sekitar 600 MHz dengan Sistem Penyiaran (Broadcasting) analog yaitu Phase Alternating Line (PAL), akan terasa dampaknya akibat gedung pencakar  langit tadi,  karena perambatan gelombang yang cenderung mendatar diatas permukaan bumi (Ground Wave). Secara otomatis di daerah-daerah perkotaan yang dikelilingi gedung bertingkat sulit  mendapatkan tayangan secara langsung (direct broadcast) dari transmisi terrestrial free to airatau secara teknis dikenal dengan blank spot area.Kondisi tersebut memberikan kesempatan untuk televisi berbayar (Pay TV ) untuk memenangkan persaingan dalam menggaet penonton dengan melakukan penetrasi penjualan layanan pada daerah tersebut , baik untuk Pay TV berbasis satelit , cable maupun digital terrestrial.
ANALISIS SEMIOTIKA CITRA POLISI DALAM FILM PENDEK “JONI SOK JAGOAN” DI YOUTUBE
Authors: Diniati Anisa , Pratiwi Soraya Ratna
Published: July 2019

Citra Kepolisian Negara Republik Indonesia (Polri) di tengah masyarakat seringkali dianggap belum maksimal dan tidak profesional. Polisi yang biasanya digambarkan sebagai sosok profesi tidak profesional dan kerjaannya hanya menilang, film pendek Joni Sok Jagoan menggambarkan citra polisi dari sudut pandang berbeda. Pemaknaan pesan tentang citra polisi yang digambarkan dalam film pendek itulah yang menjadi fokus pada penelitian ini. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana citra polisi yang ditampilkan oleh film pendek Joni Sok Jagoan melalui tanda-tanda atau pesan nonverbal tertentu. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif dengan semiotika dari Charles Sanders Peirce sebagai teknik analisisnya. Data diperoleh melalui data primer dan data sekunder. Hasilnya menunjukkan bahwa citra polisi dalam film pendek ini cukup tersampaikan dengan baik di mana masyarakat khususnya anak muda selama ini menganggap bahwa tugas polisi hanya bisa menilang dan meminta uang. Apa yang masyarakat pikirkan selama ini tentu sangat mempengaruhi citra kepolisian dalam ranah negatif. Namun, film pendek tersebut berhasil membangun citra positif polisi kembali, di mana polisi ditampilkan sebagai sosok pahlawan dengan beragam macam tugas yang harus tetap rendah hati dalam menghadapi beragam sikap para pelanggar maupun msyarakat sipil yang membutuhkan bantuan. Citra positif juga terlihat dari sikap tanggap untuk menolong orang lain meskipun orang tersebut sudah merendahkan profesinya.
党建情境教学在国企培训中的应用
Authors: 席 慧
Published: July 2019

党建教育是国企发展中较为重要的一环,其对于提升员工的思想素质水平,提高凝聚力有着重要作用。而党建情境教学的开展则是提高国企培训的重要措施,其目的在于让员工更好的了解党组织精神和政策,明确党建对于国企发展的重要作用,树立正确的价值观念和道德水准,进而为企业的进一步发展贡献力量。
APLIKASI PENGOLAHAN DATA NILAI SISWA SEKOLAH LUAR BIASA NEGERI PEMBINA PEKANBARU
Authors: Muhardi Muhardi
Published: July 2019

Sistem informasi yang memproses nilai data adalah aplikasi yang diimplementasikan menggunakan pemrograman PHP, MySQL, dan Macromedia Dreamweaver. Aplikasi ini memberikan kemudahan dalam mengakses informasi, terutama nilai siswa. Dalam mengolah data nilai di SLB Negeri Pembina Pekanbaru, masih dilakukan dengan tulisan tangan, belum terkomputerisasi, sehingga kurang mampu memberikan informasi yang akurat dan tepat. Dengan penerapan pengolahan data nilai menggunakan PHP ini diharapkan mampu menyajikan informasi dengan cermat dan akurat serta lebih efisien daripada sistem yang lama. Tujuan utama pembuatan aplikasi pengolahan data nilai sekolah adalah untuk memfasilitasi pemrosesan data nilai di SLB Negeri Pembina Pekanbaru dan memberikan informasi yang akurat. Aplikasi Pemrosesan Data Value menggunakan PHP memudahkan admin dan wali kelas dalam memproses data, terutama data nilai. Memasukkan data nilai dilakukan oleh wali yang terdiri dari nilai pengetahuan, nilai keterampilan dan nilai sikap di mana data nilai diperoleh dari guru. Data nilai diolah menjadi kartu laporan yang dibagikan kepada siswa pada akhir semester.