bluuebunny/crossref_metadata_2025 huggingface dataset:
Hibernation in Reeves’ Turtles (Mauremys reevesii) in Qichun County, Hubei Province, China: Hibernation Beginning and End and Habitat Selection
Authors: Bu Rongping , Ye Zihao , Shi Haitao
Published: September 2022

Hibernation protects turtles from extreme winter conditions. Reeves’ turtle (Mauremys reevesii) is a medium-sized aquatic turtle that lives in freshwater habitats in lowland areas with still or slowly moving water. Currently, little is known regarding its overwintering behavior. In the current study, 20 Reeves’ turtles from the wild were investigated using radiotelemetry in the field to determine the beginning and end dates of, and habitat selected for, hibernation. Hibernation began in late October 2021 and arousal began in March 2022. Reeves’ turtles do not appear to be limited in their selection of suitable hibernation habitats, which included fish ponds, abandoned ponds (ponds not being used for farming), marshes, and abandoned fields (fields not being used for farming). In the aquatic hibernation habitats, only herbage cover was significantly different between the selected and random habitats (t = 2.525, df = 9, p = 0.033). In the terrestrial hibernation habitats, there were significant differences in the canopy (Z = −2.201, p = 0.028), slope gradient (Z = −2.032, p = 0.042), herbage cover (Z = −2.379, p = 0.017), and distance from the habitat edge (Z = −2.524, p = 0.012) between the selected and random habitats. This indicates that Reeves’ turtles prefer to hibernate at the soft edges of flat habitats with low canopy and high herbage cover when hibernating in terrestrial habitats and prefer to hibernate at sites with high herbage cover when hibernating in aquatic habitats. To the best of our knowledge, this is the first study to investigate hibernation in wild Reeves’ turtles in the field, and the results identify key ecological variables correlated with habitat selection during hibernation. This knowledge could inform local conservation measures related to farming activities.
Spatiotemporal Characteristics of Drought in Central Asia from 1981 to 2020
Authors: Sun Yu , Chen Xi , Yu Yang , Qian Jing , Wang Min , Huang Shuangyan , Xing Xiuwei , Song Shiran , Sun Xiaolin
Published: September 2022

Drought is a meteorological phenomenon that threatens ecosystems, agricultural production, and living conditions. Central Asia is highly vulnerable to drought due to its special geographic location, water resource shortages, and extreme weather conditions, and poor management of water resources and reliance on irrigated agriculture exacerbate the effects of drought. In this study, the latest version of the Global Land Data Assimilation System was employed to calculate the Standardized Precipitation Evapotranspiration Index at different time scales during the period from 1981 to 2020. The varimax Rotated Empirical Orthogonal Function was applied for subregional delineation of drought patterns in Central Asia, and various methods were employed for a comparative analysis of the spatiotemporal characteristics of drought in these Central Asian subregions. The results show that drought patterns vary considerably in the Central Asian subregions. Over the past 40 years, alternating wet and dry conditions occurred in Central Asia. North Kazakhstan experienced more drought events with lower severity. East and west differences appear after 2001, the west becoming drier and the east becoming wetter. Some regions near lakes, such as Balkhash, Issyk-Kul, and the Aral Sea, suffer from droughts of long duration and high severity. In the Tianshan region, droughts in the northern slopes occur more frequently, with shorter durations and higher intensity and peaks. Northwestern China and western Mongolia have extensive agricultural land and grasslands with highly fragile ecosystems that have become progressively drier since 2001.
Clinical and Mechanistic Review of Amiodarone-Associated Optic Neuropathy
Authors: Mitchell Reece , Chacko Joseph
Published: September 2022

Amiodarone-associated optic neuropathy (AAON) is a complex clinical diagnosis, requiring distinction from non-arteritic ischemic optic neuropathy (NAION) due to a shared at-risk patient population. Diagnosis of AAON is complicated by a varied clinical presentation and incomplete pathophysiologic mechanisms. This article reviews pertinent literature for describing and clinically delineating AAON from NAION, as well as newly reported protective mechanisms of insulin-like growth factor 1 (IGF-1) and PI3K/Akt against amiodarone-induced oxidative and apoptotic injury in retinal ganglion and pigment epithelial cells. These studies offer a basis for exploring mechanisms of amiodarone toxicity in the optic nerve.
Factors Associated with Axillary Lymph Node Status in Clinically Node-Negative Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Authors: Yu Chi-Chang , Cheung Yun-Chung , Ueng Shir-Hwa , Lin Yung-Chang , Kuo Wen-Ling , Shen Shih-Che , Lo Yung-Feng , Chen Shin-Cheh
Published: September 2022

Adequate axillary lymph node (ALN) staging is critical for patients with invasive breast cancer. However, neoadjuvant chemotherapy (NAC) was associated with a lower risk of ALN metastasis compared with those who underwent primary surgery among clinically node-negative (cN0) patients. This study aimed to investigate the factors associated with ALN status among patients with cN0 breast cancer undergoing NAC. A total of 222 consecutive patients with cN0 breast cancer undergoing NAC between January 2012 and December 2021 were reviewed. Univariate and multivariate analyses were performed to compare factors associated with positive ALN status. Seventeen patients (7.7%) had ALNs metastases. Here, 90 patients (40.5%) achieved pathologic complete response in the breast (breast-pCR), and all had negative ALN status. Lymphovascular invasion (odds ratio: 29.366, p < 0.0001) was an independent risk predictor of ALN metastasis in all study populations. Among patients without breast-pCR, mastectomies were performed more frequently in patients with ALN metastasis (52.9%) than in those without metastasis (20.9%) (p = 0.013). Our findings support the omission of axillary surgery in patients who achieve breast-pCR. Prospective studies are needed to confirm the feasibility of a future two-stage surgical plan for breast-conserving surgery in patients who are likely to achieve breast-pCR during clinical evaluation.
U-Net Based Segmentation and Characterization of Gliomas
Authors: Kihira Shingo , Mei Xueyan , Mahmoudi Keon , Liu Zelong , Dogra Siddhant , Belani Puneet , Tsankova Nadejda , Hormigo Adilia , Fayad Zahi A. , Doshi Amish , Nael Kambiz
Published: September 2022

(1) Background: Gliomas are the most common primary brain neoplasms accounting for roughly 40–50% of all malignant primary central nervous system tumors. We aim to develop a deep learning-based framework for automated segmentation and prediction of biomarkers and prognosis in patients with gliomas. (2) Methods: In this retrospective two center study, patients were included if they (1) had a diagnosis of glioma with known surgical histopathology and (2) had preoperative MRI with FLAIR sequence. The entire tumor volume including FLAIR hyperintense infiltrative component and necrotic and cystic components was segmented. Deep learning-based U-Net framework was developed based on symmetric architecture from the 512 × 512 segmented maps from FLAIR as the ground truth mask. (3) Results: The final cohort consisted of 208 patients with mean ± standard deviation of age (years) of 56 ± 15 with M/F of 130/78. DSC of the generated mask was 0.93. Prediction for IDH-1 and MGMT status had a performance of AUC 0.88 and 0.62, respectively. Survival prediction of <18 months demonstrated AUC of 0.75. (4) Conclusions: Our deep learning-based framework can detect and segment gliomas with excellent performance for the prediction of IDH-1 biomarker status and survival.
Hashimoto Encephalopathy—Still More Questions than Answers
Authors: Waliszewska-Prosół Marta , Ejma Maria
Published: September 2022

The normal function of the nervous system is conditioned by the undisturbed function of the thyroid gland and its hormones. Comprehensive clinical manifestations, including neurological disorders in Hashimoto’s thyroiditis, have long been understood and, in recent years, attention has been paid to neurological symptoms in euthyroid patients. Hashimoto encephalopathy is a controversial and poorly understood disease entity and the pathogenesis of the condition remains unclear. We still derive our understanding of this condition from case reports, but on the basis of these, a clear clinical picture of this entity can be proposed. Based on a review of the recent literature, the authors present the current view on the subject, discuss controversies and questions that still remain unanswered, as well as ongoing research in this area and the results of our own work in patients with Hashimoto’s thyroiditis.
Gene Expression Profiles of Human Mesenchymal Stromal Cells Derived from Wharton’s Jelly and Amniotic Membrane before and after Osteo-Induction Using NanoString Platform
Authors: Hiew Vun Vun , Mohd Akhir Haselamirrah , Teoh Peik Lin
Published: September 2022

The use of perinatal mesenchymal stem cells (MSCs) in bone tissue regeneration and engineering to substitute bone marrow MSCs has drawn great interest due to their high yield, ease of procurement, multilineage differentiation potential and lack of ethical concerns. Although amniotic membrane (AM) and Wharton’s jelly (WJ)-derived MSCs have been widely shown to possess osteogenic differentiation potential, the intrinsic properties determining their osteogenic capacity remain unclear. Here, we compared gene expression profiles of AM- and WJ-MSCs at basal and osteogenic conditions by using the NanoString Stem Cell Panel containing regulatory genes associated with stemness, self-renewal, Wnt, Notch and Hedgehog signalling pathways. At basal condition, WJ-MSCs displayed higher expression in most genes regardless of their functional roles in self-renewal, adhesion, or differentiation signalling pathways. After osteo-induction, elevated expression of self-renewal genes ADAR and PAFAH1B1 was observed in AM-MSCs, while stemness genes MME and ALDH1A1 were upregulated in WJ-MSC. Both MSCs showed differences in genes associated with ligands, receptors and ubiquitin ligases of the Notch pathway. In addition, further evidence was demonstrated in some signalling molecules including CTBPs, protein kinases, phosphatases, RHOA, RAC1. Downstream targets HES1 and JUN especially showed higher expression in non-induced WJ-MSCs. Hedgehog genes initially expressed in both MSCs were downregulated in WJ-MSCs during osteogenesis. This study has provided insights into the intrinsic biological differences that may lead to their discrimination in therapeutic intervention.
Carbon Sequestration, Mechanical Properties and Carbonation Kinetics of PP-Fiber-Reinforced Cement-Based Composites with CO2-Curing Treatment
Authors: Hu Lingling , Chen Zhen , Hu Jun
Published: September 2022

The development of sustainability and high toughness in cement-based composites with polypropylene (PP) fiber is becoming increasingly important for future buildings, while CO2-curing treatment at early ages is precisely a promising technique for it. The present work reported the carbon sequestration and the mechanical property variations of different cement-based composites with and without PP fiber, 10% silica fume, and varied w/b ratios of 0.25 and 0.18. Carbonation–hydration kinetics of CO2-cured cement-based composites was also focused on. It was found that PP fiber promoted the CO2 uptake of cement-based composites with the utilization of two separate evaluation methods; the maximum CO2 uptake reached almost 11.0% in B-2 samples. The samples with enhanced carbon sequestration showed an obvious colorless area from the outside surface extending to the center. A much more drastic carbonation heat flow and heat release behavior than the subsequent hydration heat was also revealed in cement-based composites with CO2-curing treatment. Hence, this study provides an alternative way of using CO2-curing treatment on PP-fiber-reinforced cement-based composites to develop sustainable cement-based composites in the future.
Diffusion Bonding of Al7075 to Ti-6Al-4V by Spark Plasma Sintering and Using a Copper Interlayer
Authors: Alhazaa Abdulaziz , Albrithen Hamad , Hezam Mahmoud , Ali Shar Muhammad , Alhwaimel Ibrahim , Alharbi Yasser , Estournes Claude
Published: September 2022

Sheets of aluminum 7075 and titanium Ti-6Al-4V alloys were successfully joined using the spark plasma sintering (SPS) process. A copper foil was placed as an interlayer between the two surfaces. The bonding was made at 480 °C, 500 °C, and 520 °C with a holding time of 10 min and under a uniaxial pressure of 5 MPa and 10 MPa. The obtained bonds were analyzed by scanning electron microscopy, energy dispersive spectroscopy (SEM/EDS), and wavelength dispersive spectroscopy (WDS). It was found that copper diffused away through Al7075 and formed Al2Cu intermetallics but was not present at the joint region. The investigation of the fractured surfaces using X-ray diffraction (XRD) showed that the joint region contained TiAl3, TiAl2, and Ti3Al intermetallic compounds. The presence of the Cu foil was believed to hinder the formation of Al3Ti observed in previous studies by allowing more Ti to diffuse into the Al side.
Benefits of Table Tennis for Brain Health Maintenance and Prevention of Dementia
Authors: Yamasaki Takao
Published: September 2022

Table tennis is an extremely popular sport throughout the world as it requires no expensive equipment, specialized amenities, or physical contact among players, and the pace of play can be adapted to allow participation by players of all skill levels, ages, and abilities. It is an aerobic-dominant sport driven primarily by the phosphagen system because rallies are relatively brief (several seconds) and separated by longer rest periods. Several studies have shown that physical interventions including table tennis can help prevent cognitive decline and dementia. Accordingly, the present paper provides an overview of the basic physical and cognitive demands of table tennis, reviews previous studies reporting improvements in physical and brain health across different non-clinical and clinical populations, and critically evaluates the usefulness of table tennis intervention for the prevention of cognitive decline and dementia. This review suggests that table tennis intervention could be a powerful strategy to prevent cognitive decline and dementia in the elderly.
Cut-to-Length Harvesting Options for the Integrated Harvesting of the European Industrial Poplar Plantations
Authors: Spinelli Raffaele , Magagnotti Natascia , De Francesco Fabio , Kováč Barnabáš , Heger Patrik , Heilig Dávid , Heil Bálint , Kovács Gábor , Zemánek Tomáš
Published: September 2022

Plantation forestry has a long history in Europe and still supports local industry, generating employment, improving environmental quality, and mitigating climate change. As part of these plantations, medium-rotation poplars (5–8 years) provide good quality logs for fiber production, and the branches and tops can be converted into green energy. Finding a cost-effective harvesting system for this plantation is challenging due to the small tree size and the need for log production, which prevents whole-tree chipping. To verify the economic benefit of using small mechanized cut-to-length (CTL) technology, four different CTL chains were tested in western Slovakia. All chains tested consisted of a harvester and a forwarder. Each machine had a skilled operator and was timed while cutting and processing (or forwarding) eight experimental sample plots. Sample plots were randomly assigned to each treatment, and each one covered an area between 0.08 and 0.10 ha (120–170 trees). Harvester productivity ranged from 2.2 to 4.2 bone-dry tons per scheduled machine hour (BDT SMH−1), and harvester cost from EUR 11 to EUR 22 BDT−1. Forwarding productivity and cost ranged from EUR 2.0 to 4.5 BDT SMH−1 and from EUR 9 to 20 BDT−1. Total harvesting costs ranged between EUR 26 and 36 BDT−1. Choosing a smaller harvester is preferable due to the small tree size, which caps productivity regardless of a machine’s intrinsic potential. Furthermore, small harvesters and forwarders are lighter on the ground, which can be a valuable asset on the many wet sites planted with poplar.
Ecological Response of Urban Forest Carbon Density to Site Conditions: A Case Study of a Typical Karst Mountainous Regions in Southwest China
Authors: Zhou Xuexia , Hu Changyue , Wang Zhijie
Published: September 2022

Understanding the ecological constraints of limiting the magnitude and the allocation of carbon density is critical for executing adaptive forest management programs and upgrading the size of carbon sinks. Taking a typical karst mountainous region Guiyang City as a case study area, this study computed the biomass of different forest types using the volume–biomass equations and mapped the carbon density distribution of forests. Furthermore, the random forest algorithm and spatial autoregression model were adopted to reveal the effects of site conditions on carbon density in karst forests. The results indicate that the forest ecosystems of Guiyang City had a high carbon sequestration potential, and there was a significant difference in the carbon density of forests in terms of space dimensions. Road density, 0 cm cation exchange capacity, and soil parent materials were the dominant factors determining the spatial distribution of homogeneous units with different levels of carbon density. This study underlines the urgency adapting to the growing conditions of forests in terms of complex site conditions, and provides a scientific basis for optimizing forest management practices, to maintain their carbon sequestration capacity under urbanization pressure and fragile habitats.
Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence
Authors: Cui Xiaoling , Hao Xuxiao , Wen Jie , Zhang Shangli , Zhao Baoxiang , Miao Junying
Published: September 2022

Researchers are paying more and more attention to aging, especially skin aging. Therefore, it is urgent to find an effective way to inhibit aging. Here, we report a small chemical molecule, HCP1, that inhibited the senescence of human dermal fibroblasts (HDFs). First, we performed morphological experiment and found that HCP1-treated HDFs were no longer elongated and flat compared to DMSO-treated groups. Next, we found that the number of β-gal positive cells decreased compared to DMSO-treated groups. Through flow cytometry, western blot, and immunofluorescence, we found that HCP1 could inhibit the senescence of HDFs. In the study of the mechanism, we found that HCP1 could regulate the AMPK/mTOR signal pathway through glucose-regulated protein 94 (Grp94). In addition, we found that HCP1 could promote the interaction between Grp94 and lysosomes, which led to an increase in the activity of lysosomes and inhibited the senescence of HDFs. At the same time, we found that HCP1 decreased the concentration of Ca2+ in mitochondria, inhibiting the senescence of HCP1. Therefore, we propose that HCP1 is a potential aging-inhibiting compound, and provide a new idea for the development of senescence-inhibiting drugs.
Dynamic Change in Starch Biosynthetic Enzymes Complexes during Grain-Filling Stages in BEIIb Active and Deficient Rice
Authors: Ying Yining , Xu Feifei , Zhang Zhongwei , Tappiban Piengtawan , Bao Jinsong
Published: September 2022

Starch is the predominant reserve in rice (Oryza sativa L.) endosperm, which is synthesized by the coordinated efforts of a series of starch biosynthetic-related enzymes in the form of a multiple enzyme complex. Whether the enzyme complex changes during seed development is not fully understood. Here, we investigated the dynamic change in multi-protein complexes in an indica rice variety IR36 (wild type, WT) and its BEIIb-deficient mutant (be2b) at different developmental stages. Gel permeation chromatography (GPC) and Western blotting analysis of soluble protein fractions revealed most of the enzymes except for SSIVb were eluted in smaller molecular weight fractions at the early developing stage and were transferred to higher molecular weight fractions at the later stage in both WT and be2b. Accordingly, protein interactions were enhanced during seed development as demonstrated by co-immunoprecipitation analysis, suggesting that the enzymes were recruited to form larger protein complexes during starch biosynthesis. The converse elution pattern from GPC of SSIVb may be attributed to its vital role in the initiation step of starch synthesis. The number of protein complexes was markedly decreased in be2b at all development stages. Although SSIVb could partially compensate for the role of BEIIb in protein complex formation, it was hard to form a larger protein complex containing over five proteins in be2b. In addition, other proteins such as PPDKA and PPDKB were possibly present in the multi-enzyme complexes by proteomic analyses of high molecular weight fractions separated from GPC. Two putative protein kinases were found to be potentially associated with starch biosynthetic enzymes. Collectively, our findings unraveled a dynamic change in the protein complex during seed development, and potential roles of BEIIb in starch biosynthesis via various protein complex formations, which enables a deeper understanding of the complex mechanism of starch biosynthesis in rice.
Shedding Light on the Dark Web: Authorship Attribution in Radical Forums
Authors: Ranaldi Leonardo , Ranaldi Federico , Fallucchi Francesca , Zanzotto Fabio Massimo
Published: September 2022

Online users tend to hide their real identities by adopting different names on the Internet. On Facebook or LinkedIn, for example, people usually appear with their real names. On other standard websites, such as forums, people often use nicknames to protect their real identities. Aliases are used when users are trying to protect their anonymity. This can be a challenge to law enforcement trying to identify users who often change nicknames. In unmonitored contexts, such as the dark web, users expect strong identity protection. Thus, without censorship, these users may create parallel social networks where they can engage in potentially malicious activities that could pose security threats. In this paper, we propose a solution to the need to recognize people who anonymize themselves behind nicknames—the authorship attribution (AA) task—in the challenging context of the dark web: specifically, an English-language Islamic forum dedicated to discussions of issues related to the Islamic world and Islam, in which members of radical Islamic groups are present. We provide extensive analysis by testing models based on transformers, styles, and syntactic features. Downstream of the experiments, we show how models that analyze syntax and style perform better than pre-trained universal language models.
Flight Performance, Fecundity, and Ovary Development of Grapholita molesta (Lepidoptera: Torticidae) at Different Ages
Authors: Su Sha , Zhang Xiaohe , Zhang Jilong , Huang Baojian , Jian Chengzhi , Peng Xiong , Vreysen Marc J. B. , Chen Maohua
Published: September 2022

Grapholita molesta is one of the most serious pests in fruits orchards. Flight performance of male insects and fecundity of female insects are important quality control parameters when moths are mass-reared for use in environment-friendly control strategies such as the sterile insect technique (SIT). However, information about flight performance, fecundity, and ovary development of G. molesta at different ages is scarce. In this study, we used a flight mill information system to measure the flight ability of female and male adults of G. molesta at different ages, and evaluated fecundity and ovarian development of female adults at different ages. The results demonstrated that the flight parameters (cumulative flight distance, cumulative flight time, maximum flight distance and maximum flight duration) of female and male G. molesta varied with age. Six-day-old female moths and three-day-old male moths were the strongest fliers, whereas the fecundity of one-day and two-day-old female moths was significantly lower than that of three to seven-day-old females. Five-day-old females had the highest fecundity. Their ovaries demonstrated mature eggs in the lateral and middle oviducts as of the third day post-emergence. It is suggested that the optimal age for moths to be released in SIT programs is three days, and moths older three days can be used for mass-rearing in a factory.
Antibiotic Treatment Reduced the Gut Microbiota Diversity, Prolonged the Larval Development Period and Lessened Adult Fecundity of Grapholita molesta (Lepidoptera: Tortricidae)
Authors: Zhang Xuan , Wang Xing , Guo Zikun , Liu Xueying , Wang Ping , Yuan Xiangqun , Li Yiping
Published: September 2022

Grapholita molesta, the oriental fruit moth, is a serious pest of fruit trees with host transfer characteristics worldwide. The gut microbiota, which plays a crucial part in insect physiology and ecology, can be influenced by many elements, such as antibiotics, temperature, diet, and species. However, the effects of antibiotics on G. molesta gut microbiota are still unclear. In this study, we selected five common antibiotic agents to test the inhibition of G. molesta gut microbiota, and found ciprofloxacin shown the best antibacterial activity. After feeding 1 μg/mL of ciprofloxacin, the relative abundance of Actinobacteria and Cyanobacteria decreased significantly, while that of Firmicutes and Bacteroidetes increased. PICRUSt2 analysis indicated that most functional prediction categories were enriched in the G. molesta gut, including amino acid transport and metabolism, translation, ribosomal structure and biogenesis, carbohydrate transport and metabolism, transcription, cell wall/membrane/envelope biogenesis, and energy production and conversion. Finally, ciprofloxacin feeding significantly affected larval growth, development, and reproduction, resulting in prolonged larval development duration, shortened adult longevity, and significantly decreased single female oviposition and egg hatchability. In addition, we isolated and purified some culturable bacteria belonging to Proteobacteria, Firmicutes, Actinobacteria, and cellulase-producing bacteria from the G. molesta midgut. In brief, our results demonstrate that antibiotics can have an impact on G. molesta gut bacterial communities, which is beneficial for host growth and development, as well as helping female adults produce more fertile eggs. These results will thus provide a theoretical reference for developing new green control technology for G. molesta.
Generic Patterns for Intrusion Detection Systems in Service-Oriented Automotive and Medical Architectures
Authors: Puder Andreas , Rumez Marcel , Grimm Daniel , Sax Eric
Published: September 2022

To implement new software functions and more flexible updates in the future as well as to provide cloud-based functionality, the service-oriented architecture (SOA) paradigm is increasingly being integrated into automotive electrical and electronic architecture (E/E architectures). In addition to the automotive industry, the medical industry is also researching SOA-based solutions to increase the interoperability of devices (vendor-independent). The resulting service-oriented communication is no longer fully specified during design time, which affects information security measures. In this paper, we compare different SOA protocols for the automotive and medical fields. Furthermore, we explain the underlying communication patterns and derive features for the development of an SOA-based Intrusion Detection System (IDS).
Identification of Relatively Weak Areas of Planar Structures Based on Modal Strain Energy Decomposition Method
Authors: Wang Dongwei , Liang Kaixuan , Sun Panxu
Published: September 2022

Identifying relatively weak areas is of great significance for improving the seismic reliability of structures. In this paper, a modal strain energy decomposition method is proposed, which can realize the decoupling of the comprehensive modal strain energy of a planar structure into three basic modal strain energies. According to the decomposition results, the modal strain energy decomposition diagram and the modal strain energy cloud diagram can be drawn so as to realize the quantitative and visual analysis of the vibration modes. The method is independent of load cases and can identify relatively weak areas of a structure from the perspective of inherent characteristics. The comparison with the shaking table test results of the two-story shear wall shows that the modal strain energy decomposition method can effectively identify the type of the relatively weak area of a structure and locate the position of the relatively weak area. Finally, the 6-story shear wall is analyzed by the modal strain energy decomposition method, and the relatively weak areas under the first two vibration modes are identified.
Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.
Authors: Limon Anne-Claire D. , Patabendige Hiran M. L. W. , Azhari Ala , Sun Xingmin , Kyle Dennis E. , Wilson Nerida G. , Baker Bill J.
Published: September 2022

Chemical investigation of an Antarctic deep-water octocoral has led to the isolation of four new compounds, including three illudalane sesquiterpenoids (1–3) related to the alcyopterosins, a highly oxidized steroid, alcyosterone (5), and five known alcyopterosins (4, 6–9). The structures were established by extensive 1D and 2D NMR analyses, while 9 was verified by XRD. Alcyopterosins are unusual for their nitrate ester functionalization and have been characterized with cytotoxicity related to their DNA binding properties. Alcyopterosins V (3) and E (4) demonstrated single-digit micromolar activity against Clostridium difficile, an intestinal bacterium capable of causing severe diarrhea that is increasingly associated with drug resistance. Alcyosterone (5) and several alcyopterosins were similarly potent against the protist Leishmania donovani, the causative agent of leishmaniasis, a disfiguring disease that can be fatal if not treated. While the alcyopterosin family of sesquiterpenes is known for mild cytotoxicity, the observed activity against C. difficile and L. donovani is selective for the infectious agents.
Asymmetric Jetting during the Impact of Liquid Drops on Superhydrophobic Concave Surfaces
Authors: Chen Chengmin , Zhong Hongjun , Liu Zhe , Wang Jianchun , Wang Jianmei , Liu Guangxia , Li Yan , Zhu Pingan
Published: September 2022

The impact of liquid drops on superhydrophobic solid surfaces is ubiquitous and of practical importance in many industrial processes. Here, we study the impingement of droplets on superhydrophobic surfaces with a macroscopic dimple structure, during which the droplet exhibits asymmetric jetting. Systematic experimental investigations and numerical simulations provide insight into the dynamics and underlying mechanisms of the observed phenomenon. The observation is a result of the interaction between the spreading droplet and the dimple. An upward internal flow is induced by the dimple, which is then superimposed on the horizontal flow inside the spreading droplet. As such, an inclined jet is issued asymmetrically into the air. This work would be conducive to the development of an open-space microfluidic platform for droplet manipulation and generation.
Occurrence Characteristics of Magnetite and Aeromagnetic Prospecting Northeast of Hebei Province
Authors: Liu Yan-Xu , Li Wen-Yong , Liu Zhi-Yuan , Zhao Jia-Wei , Cao An-Qi , Gao Shan , Wang Li-Jie , Yang Cheng
Published: September 2022

The occurrence characteristics of magnetite and the methods to quickly and effectively explore are important topics for ore prospecting in the new era. Taking northeast of Hebei Province of China as an example, this article aimed at an important strategic mineral of magnetite, then discussed its distribution characteristics and aeromagnetic exploration methods of it. First of all, we discuss the occurrence characteristics of sedimentary metamorphic and magmatic magnetite. Then, using the latest high-precision aeromagnetic data, combined with the geological outcrops, known iron deposits, ground magnetic surveys, and verification, we studied the relationship between the aeromagnetic anomalies and iron deposits through potential field conversion processing of the reduction to the pole, vertical derivative, upward continuation and residual anomaly, and the forward modeling and inversion methods of 2.5 D optimization fitting. Next, we summarize the metallogenic conditions and attributes of aeromagnetic prospecting and make magnetite predictions. In addition, it has suitable magnetite prospecting potential in the Laochenjia, Dabai, Jiuwuying, Beierying, Sidaogoumen, and Wuyingzi aeromagnetic anomaly regions. In conclusion, these regions have aeromagnetic anomalies with high amplitudes, large scales, and favorable metallogenic backgrounds for magmatic rocks, strata, and structures caused by concealed magnetite. In addition, they have great prospecting potential. Eventually, we hope this research method in this article can provide a reference for magnetite exploration in other areas with similar geological conditions.
Stability Assessment of the Slopes of an Oceanside Coral Limestone Quarry under Drawdown Condition of Semidiurnal Ocean Tides
Authors: Onyango Joan Atieno , Sasaoka Takashi , Shimada Hideki , Hamanaka Akihiro , Moses Dyson
Published: September 2022

Vipingo quarry in Kilifi county, Kenya, is one of the quarries supplying coral limestone for limestone manufacturing in the coastal region. Due to its close proximity to the Indian ocean, the semidiurnal ocean tides tend to have an influence on the stability of the quarry slopes adjacent to the shoreline. Finite element numerical analysis using the generalized Hoek–Brown criterion is conducted to assess the stability condition of the slopes followed by slope-angle optimization to determine the safest overall slope angle as well as analyzing the stability of the slopes due to action of varying ocean tides. The optimum overall slope angles for various excavation depths are found to be 52° for 20 m, 46° for 30 m, 42° for 40 m, and 39° for 50 m, which are the same even with varying distance of the slope face from the shoreline. A parametric analysis shows that there is no significant effect of the tides on slope stability for excavations above the water table, but as the quarry gets deeper, the slope stability is affected. A sensitivity factor (ζ) is introduced, being a measure of how much the slope safety factor is reduced as a result of the semidiurnal tidal action.
Synthesis, Applications and Biological Impact of Nanocellulose
Authors: Sunasee Rajesh , Ckless Karina
Published: September 2022

Interest in cellulose-based nanomaterials has continued to increase dramatically in the past few years, especially with advances in the production routes of nanocellulose—such as cellulose nanocrystals (CNC), cellulose nanofibrils (CNF) and bacterial nanocellulose (BNC)—that tailor their performances [...]
The Lattice Distortion, Defect Evolution and Electrochemical Performance Improvement in Zn-VO2(B) Nanorods
Authors: Liu Dewei , Zhang Qijie , Chen Xiaohong , Zhu Penggang , Yan Fufeng , Wang Xuzhe , Dai Haiyang , Chen Jing , Gong Gaoshang , Shang Cui , Xie Luogang , Zhai Xuezhen
Published: September 2022

Cathode materials of energy storage batteries have attracted extensive attention because of the importance in deciding the rate performance and long cycle property of batteries. Herein, we report a simple and environmentally friendly solvothermal method to prepare Zn-doped VO2(B) cathode materials. The introduction of zinc ions can effectively regulate the lattice structure, surface morphology and internal defect state of Zn-VO2(B) nano materials. The sample with Zn content x = 1.5% has smaller cell volume and grain size, and higher concentration of vacancy defects. These microstructures ensure the structural stability during ion embedding process and, thus, this sample shows excellent electrochemical performances. The capacitance retention rate still maintains 88% after 1000 cycles at the current density of 0.1 A·g−1. The enhanced performances of Zn-doped VO2(B) samples may lay a foundation for the improvement of electrochemical performances of VO2(B) cathode materials for energy storage batteries in the future.
Photocatalytic Water Splitting Promoted by 2D and 3D Porphyrin Covalent Organic Polymers Synthesized by Suzuki-Miyaura Carbon-Carbon Coupling
Authors: Novoa-Cid Maria , Melillo Arianna , Ferrer Belén , Alvaro Mercedes , Baldovi Herme G.
Published: September 2022

This work deals with the synthesis of metal-free and porphyrin-based covalent organic polymers (COPs) by the Suzuki–Miyaura coupling carbon-carbon bond forming reaction to study the photocatalytic overall water splitting performance. Apart from using 5,10,15,20-Tetrakis-(4-bromophenyl)porphyrin, we have chosen different cross-linker monomers to induce 2-dimensional (2D) or 3-dimensional (3D) and different rigidity in their resulting polymeric molecular structure. The synthesised COPs were extensively characterised to reveal that the dimensionality and flexibility of the molecular structure play an intense role in the physical, photochemical, and electronic properties of the polymers. Photoinduced excited state of the COPs was evaluated by nanosecond time-resolved laser transient absorption spectroscopy (TAS) by analysing excited state kinetics and quenching experiments, photocurrent density measurements and photocatalytic deposition of Ru3+ to RuO2, and photocatalysis. In summary, TAS experiments demonstrated that the transient excited state of these polymers has two decay kinetics and exhibit strong interaction with water molecules. Moreover, photocurrent and photocatalytic deposition experiments proved that charges are photoinduced and are found across the COP molecular network, but more important charges can migrate from the surface of the COP to the medium. Among the various COPs tested, COP–3 that has a flexible and 3D molecular structure reached the best photocatalytic performances, achieving a photocatalytic yield of 0.4 mmol H2 × gCOP–3−1 after 3 h irradiation.
Moving forward the Effects of Gene–Diet Interactions on Human Health
Authors: Konstantinidou Valentini , Garcia-Santamarina Sarela
Published: September 2022

Back in 2010, when we first published data on the in vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet [...]
A Composition of Phytonutrients for Glycemic and Weight Management
Authors: Urasaki Yasuyo , Le Thuc T.
Published: September 2022

Maintaining healthy body weight is an important component of any effective diabetes management plan. However, glycemic management using insulin generally leads to weight gain. In addition, weight loss medications prescribed for diabetes management are often associated with adverse side effects, which limit their long-term usage. Alternatively, nutrition intervention provides a safe, readily accessible, and inexpensive option for diabetes management. This study describes a composition of phytonutrients comprising berberine, cinnamaldehyde, and curcumin for glycemic and weight management. Functional complementarity between berberine, cinnamaldehyde, and curcumin provides an effective means to improve insulin sensitivity without increasing adiposity. In primary human omental preadipocytes, cinnamaldehyde and curcumin additively enhance insulin-stimulated activation of Akt2 and glucose uptake, whereas berberine inhibits de novo fatty acid biosynthesis and fat cell differentiation. In a diet-induced obesity murine model, a dietary supplement with berberine, cinnamaldehyde, and curcumin prevents weight gain, improves glucose tolerance, and reduces HbA1c, blood lipids, visceral adiposity, and liver steatosis. Collectively, the composition of phytonutrients comprising berberine, cinnamaldehyde, and curcumin protects against obesity and pre-diabetic conditions in a diet-induced obesity murine model. Safety and efficacy assessment of nutrition intervention using combined berberine, cinnamaldehyde, and curcumin for glycemic and weight management in future clinical trials are warranted.
Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
Authors: Hidalgo-Moyano Cristina , Rangel-Zuñiga Oriol Alberto , Gomez-Delgado Francisco , Alcala-Diaz Juan F. , Rodriguez-Cantalejo Fernando , Yubero-Serrano Elena M. , Torres-Peña Jose D. , Arenas-de Larriva Antonio P. , Camargo Antonio , Perez-Martinez Pablo , Lopez-Miranda Jose , Delgado-Lista Javier
Published: September 2022

We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative stress (OxS) and inflammation in patients with coronary heart disease (CHD). LTL, inflammation, OxS markers (at baseline and after 4 years of follow-up) and SIRT1-Single Nucleotide Polymorphisms (SNPs) (rs7069102 and rs1885472) were determined in patients from the CORDIOPREV study. We analyzed the genotype-marker interactions and the effect of diet on these interactions. Regardless of the diet, we observed LTL maintenance in GG-carriers for the rs7069102, in contrast to carriers of the minor C allele, where it decreased after follow-up (p = 0.001). The GG-carriers showed an increase in reduced/oxidized glutathione (GSH/GSSG) ratio (p = 0.003), lower lipid peroxidation products (LPO) levels (p < 0.001) and a greater decrease in tumor necrosis factor-alpha (TNF-α) levels (p < 0.001) after follow-up. After the LF diet intervention, the GG-carriers showed stabilization in LTL which was significant compared to the C allele subjects (p = 0.037), although the protective effects found for inflammation and OxS markers remained significant after follow-up with the two diets. Patients who are homozygous for the SIRT1-SNP rs7069102 (the most common genotype) may benefit from healthy diets, as suggested by improvements in OxS and inflammation in patients with CHD, which may indicate the slowing-down of the aging process and its related diseases.
Assessment of the Nutritional Quality of Plant Lipids Using Atherogenicity and Thrombogenicity Indices
Authors: Khalili Tilami Sarvenaz , Kouřimská Lenka
Published: September 2022

Dietary lipids derived from plants have different compositions of individual fatty acids (FA), providing different physical and chemical properties with positive or adverse health effects on humans. To evaluate the nutritional value and assess the FA composition of various plants, the atherogenicity (AI) and thrombogenicity (TI) indices were calculated and reviewed for nine different categories of fats and oils. This included common oils, unconventional oils, nut oils originating from temperate regions, Amazonian and tropical fats and oils, chia seed oil, traditional nuts originating from temperate regions, unconventional nuts, seeds, and fruits, and their products. The main factors influencing fatty acid composition in plants are growth location, genotype, and environmental variation, particularly temperature after flowering, humidity, and frequency of rainfall (exceeding cultivar variation). The lowest AI was calculated for rapeseed oil (0.05), whereas the highest value was obtained for tucuman seeds (16.29). Chia seed oil had the lowest TI (0.04), and murumuru butter had the highest (6.69). The differences in FA composition and subsequent changes in the lipid health indices of the investigated fats and oils indicate their importance in the human diet.
High Prevalence of Glaucoma among Patients in an Onchocerciasis Endemic Area (Mahenge, Tanzania)
Authors: Otiti-Sengeri Juliet , Omaido Blair Andrew , Bhwana Dan , Nakanjako Damalie , Missiru Malik , Muwonge Musa , Amaral Luis-Jorge , Mmbando Bruno P. , Colebunders Robert
Published: September 2022

Onchocerciasis is known to cause skin lesions and blindness, but there is also epidemiological evidence that onchocerciasis is associated with epilepsy, including nodding syndrome. We carried out ocular exams in persons with epilepsy in Mahenge, an onchocerciasis endemic area with a high prevalence of epilepsy in Tanzania. We recruited 278 consecutive persons with epilepsy attending the epilepsy clinic at Mahenge hospital and satellite clinics in rural villages. They underwent a general physical and a detailed ocular examination and were tested for onchocerciasis Ov16 IgG4 antibodies. Glaucoma was defined by a raised intraocular pressure above 21 mmHg with evidence of typical glaucomatous disc changes in one or both eyes. Among the 278 participants, median age 27 (IQR 21–38) years, 55.4% were female; 151/210 (71.9%) (95% CI: 65.3–77.9) were Ov16 positive. The most frequent ophthalmic lesions were glaucoma (33.1%), vitreous opacities (6.5%) and cataracts (2.9%). In multivariate analysis, glaucoma (adjusted IRR = 1.46; 95% CI: 1.24–1.70) and age (adjusted IRR = 1.01; 95% CI: 1.01–1.02) were significantly associated with onchocerciasis. In conclusion, a high prevalence of glaucoma was observed among Ov16 positive persons with epilepsy. Persons with epilepsy with O. volvulus infection should undergo screening for glaucoma to prevent one of the causes of preventable blindness.
Montelukast and Acute Coronary Syndrome: The Endowed Drug
Authors: Alomair Basil Mohammed , Al-kuraishy Hayder M. , Al-Gareeb Ali I. , Al-Hamash Sadiq M. , De Waard Michel , Sabatier Jean-Marc , Saad Hebatallah M. , El-Saber Batiha Gaber
Published: September 2022

Acute coronary syndrome (ACS) is a set of signs and symptoms caused by a reduction of coronary blood flow with subsequent myocardial ischemia. ACS is associated with activation of the leukotriene (LT) pathway with subsequent releases of various LTs, including LTB4, LTC4, and LTD4, which cause inflammatory changes and induction of immunothrombosis. LTs through cysteine leukotriene (CysLT) induce activation of platelets and clotting factors with succeeding coronary thrombosis. CysLT receptor (CysLTR) antagonists such as montelukast (MK) may reduce the risk of the development of ACS and associated complications through suppression of the activation of platelet and clotting factors. Thus, this critical review aimed to elucidate the possible protective role of MK in the management of ACS. The LT pathway is implicated in the pathogenesis of atherosclerosis, cardiac hypertrophy, and heart failure. Inhibition of the LT pathway and CysL1TR by MK might be effective in preventing cardiovascular complications. MK could be an effective novel therapy in the management of ACS through inhibition of pro-inflammatory CysLT1R and modulation of inflammatory signaling pathways. MK can attenuate thrombotic events by inhibiting platelet activation and clotting factors that are activated during the development of ACS. In conclusion, MK could be an effective agent in reducing the severity of ACS and associated complications. Experimental, preclinical, and clinical studies are recommended to confirm the potential therapeutic of MK in the management of ACS.