bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, In silico and In vitro Analysis of Hydrazones as Potential Antituberculosis Agents
Authors: Thorat Bapu R. , Mali Suraj N. , Rani Deepa , Yamgar Ramesh S.
Published: March 2020

:

Tuberculosis (TB) is a major cause of mortality and illness as reported by the W.H.O in
2019. The WHO report also mentioned the fact that about 10.0 million people fell ill with tuberculosis
in the year 2018. Hydrazide–hydrazones having azomethine group (–NH–N=CH–) connected
with carbonyl group is reported for the number of bioactivities like anti-inflammatory, anticonvulsant,
anticancer, antiviral and antiprotozoal.

Objective:

The objective of our current study is to design and synthesis of more potent Hydrazide–hydrazones containing anti-Tubercular agents.

Methods:

In the current study, we synthesized 10 hydrazones (3a-3j) by stirring corresponding
benzohydrazides (2) with substituted aldehydes (1a-j) in ethanol as a solvent and acetic acid as a
catalyst at room temperature. All synthesized compounds were characterized by various spectroscopic
techniques including elemental analysis, ultraviolet–visible spectroscopy, fluorescence, fourier-
transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. Compounds
(3a-3j) were tested for in vitro anti-TB activity using Microplate Alamar Blue Assay (MABA).

Results:

All our synthesized compounds (3a-3j) were found to be potent against Mycobacteria tuberculosis
(H37RV strain) with MIC (minimum inhibitory concentrations) values of 3.125-50
μg/mL. The hydrazide CO-NH protons in (3a-j) compounds are highly deshielded and showed
broad singlet at 9.520-9.168 ppm. All the compounds were found to have more intense emission in
the 416 – 429 nm regions and strong absorption in the regions of 316 – 327 nm. Synthesized compounds
were also tested for in silico analysis using different software for their Absorption, Distribution,
Metabolism, Excretion and Toxicity (ADMET) analysis. All the compounds were found to be
in silico non-carcinogenic.

Conclusion:

Our current study will definitely help the medicinal chemists for better designing of newer potent anti-Tubercular agents.
Dietary Melatonin Protects Against Behavioural, Metabolic, Oxidative, and Organ Morphological Changes in Mice that are Fed High-Fat, High- Sugar Diet
Authors: Onaolapo Adejoke Yetunde , Adebisi Ebenezer Oladimeji , Adeleye Adegbayi Emmanuel , Olofinnade Anthony Tope , Onaolapo Olakunle James
Published: March 2020

Background :

Metabolic syndrome is a complex pattern of disorders that occur jointly and is associated with an increased risk of cardiovascular and cerebrovascular disease. Therefore the need for more-efficient options of treatment has become imperative.

Objective :

This study examined the effect of dietary-melatonin in the management of behavioural, metabolic, antioxidant, and organ changes due to high-fat/high-sugar (HFHS) diet-induced metabolic syndrome in mice.

Methods:

Mice were randomly assigned into five groups of ten animals each. Groups were normal control [fed standard diet (SD)], HFHS control, and 3 groups of melatonin incorporated into HFHS at 2.5, 5, and 10 mg/kg of feed. Mice were fed for seven weeks, and body weight was assessed weekly. Open-field behaviours, radial-arm, and Y-maze spatial memory were scored at the end of the experimental period. Twenty-four hours after the last behavioural test, blood was taken for estimation of blood glucose levels after an overnight fast. Animals were then euthanised, and blood was taken for estimation of plasma insulin, leptin, and adiponectin levels, and serum lipid profile. The liver, kidneys, and brain were excised and processed for general histology, while homogenates of the liver and whole brain were used to assess oxidative stress parameters.

Results:

Results showed that dietary melatonin (compared to HFHS diet) was associated with a decrease in body weight, food intake, and novelty-induced behaviours; and an increase in spatial-working memory scores. A decrease in glucose, insulin, leptin, and malondialdehyde levels; and an increase in adiponectin levels and superoxide dismutase activity were also observed. Histomorphological/ histomorphometric examination revealed evidence of organ injury with HFHS diet, and varying degrees of amelioration with melatonin-supplemented diet.

Conclusion:

In conclusion, dietary melatonin supplementation may have beneficial effects in the management of the metabolic syndrome..
Deconstruction of minimalist residential design development practice in South Kuta
Authors: Artadi I Made Pande , Kumbara A. A. Ngurah Anom , Salain Putu Rumawan , Pujaastawa Ida Bagus Gde
Published: March 2020

Minimalist residential develops was received massively in the middle of Balinese society, carrying the values ??of modernity by prioritizing function, the strength of ratio, and ignoring the past (ahistoric). The development and acceptance of these residences were contrary to Bali Provincial Regulation No. 05/2005 which requires residential buildings to display Balinese style. Massive acceptance of minimalist residential has implications in the dimensions of Balinese environmental, social, and cultural identity. The purpose of the study was to uncover the factors underlying the development and acceptance of minimalist dwelling in South Kuta. The research approach used was the cultural studies and design studies approach. The type of data collected was qualitative data obtained through observation, in-depth interviews, reading, and document checking. All data were analyzed using the qualitative interpretative analysis method. To understand and interpret the data, theories of deconstruction, consumerism, semiotics and identity theory are used. The results revealed that the development and acceptance of a minimalist residential design on a massive scale in South Kuta was due to the factor of capitalism and lifestyle changes.
El género Daldinia (Sordariomycetes, Ascomycota) en México
Authors: Barbosa-Reséndiz Anabel , Valenzuela Ricardo , Sánchez-Flores Marcos , Bautista-Hernández Silvia , Cobos-Villagrán Aurora , Pérez-Valdespino Abigail , Espinoza-Mellado Maria del Rosario , Martínez-Pineda Michelle , Raymundo Tania
Published: March 2020

Resumen:Antecedentes y Objetivos: El género Daldinia, con 48 especies a nivel mundial, se caracteriza por presentar peritecios inmersos en estromas globosos a clavados de colores cobrizos, violáceos, vináceos, marrones a negros, liberando pigmentos de colores ocráceos, púrpuras, verdosos y grisáceos en KOH. Está caracterizado por ascas cilíndricas estipitadas con poro apical amiloide, y ascosporas elipsoidales marrones lisas u ornamentadas. El estado asexual fue descrito en el género Nodulisporium. Actualmente, se sabe que el grupo es principalmente endófito. El objetivo del presente estudio fue realizar una revisión taxonómica del género Daldinia en México, basada en caracteres macro y micromorfológicos y la observación de las esporas al MEB para identificar a las especies.Métodos: Los ejemplares fueron estudiados, descritos y determinados de acuerdo con las técnicas tradicionales en micología. Adicionalmente, las esporas se observaron al microscopio electrónico de barrido. El material está depositado en la colección de hongos del herbario ENCB.Resultados clave: Se determinaron 14 especies de Daldinia en México; de éstas, D. decipiens, D. cuprea, D. petriniae y D. rehmii se citan por primera vez para el país. De acuerdo con el hábitat, las especies de este género se asociaron principalmente al bosque tropical caducifolio. Daldinia childiae, D. eschscholtzii y D. vernicosa son las especies con mejor distribución en el territorio nacional.Conclusiones: El género Daldinia se encuentra bien representado en México, siendo uno de los mejor estudiados de la familia Hypoxylaceae. El género tiene una distribución principalmente tropical, con más de 80% de las especies descritas. En regiones templadas su distribución es restringida y manifiesta una mayor especificidad por el hospedero, principalmente Alnus y Quercus. El estado de Oaxaca fue la entidad con mayor riqueza de especies.
A EXPERIÊNCIA DE ESTUDANTES AFRICANOS NO BRASIL
Authors: Müller Maria Lúcia Rodrigues , Silva Áurea Gardeni Sousa da
Published: March 2020

Este artigo pretende relatar os aspectos referentes a situações de racismo e discriminação racial vivenciada pelos estudantes dos Países Africanos de Língua Oficial Portuguesa (PALOP) que ingressaram nas Instituições de Ensino Superior Brasileiras através do Programa Estudante de Convênio de Graduação (PEC-G).Estabeleceu-se como objetivo neste trabalho compreender como é a experiência do estudante-convênio oriundo dos PALOP em duas capitais do Centro Oeste brasileiro, Brasília-DF, capital do país e Cuiabá-MT. Foram entrevistados alunos e ex-alunos da Universidade de Brasília (UnB) e da Universidade Federal de Mato Grosso (UFMT). Para a compreensão dos aspectos propostos as pesquisadoras recorreram àsentrevistas em profundidade e à observação participante. Os dados obtidos informam que as universidades brasileiras não dispõem de estrutura para receber os estudante dos PALOP. Ademais, ser africano e negro no Brasil é uma experiência que impõe muitas dificuldades. Professores e colegas de curso pouco ou nada sabem sobre arealidade da África e reproduzem as percepções estereotipadas sobre o continente, circunstância incômoda para os estudantes. A prática das relações entre os alunos oriundos dos PALOP e os brasileiros é marcada também pelo racismo, discriminação e preconceito racial.
AS MULHERES NEGRAS BRASILEIRAS E O ACESSO À EDUCAÇÃO SUPERIOR
Authors: Mascarenhas Queiroz Delcele , Moreira dos Santos Carlinda
Published: March 2020

O artigo apresenta conclusões de pesquisa que indagou sobre as relações de gênero, no contexto da política de ações afirmativas adotada para negros, por universidades brasileiras. A partir de estudo que indicava uma desvantagem das mulheres negras com a implementação dessa política, na UFBA, a pesquisa examinou a participação de mulheres negras, em cursos de elevado prestígio social naquela Instituição, em dois momentos: 2006 e 2010. Buscou ainda compre-ender o que se passa no cotidiano das mulheres que ali ingressaram. Os resultados indicam que o crescimento da participação de mulheres nesses cursos ocorre desigualmente entre os segmentos raciais. Confirmando o estudo que deu origem à pesquisa, as mulheres pretas, embora tivessem obtido uma sensível elevação de sua participação, formam o contingente de menor expressividade nos cursos de alto prestígio, mesmo naqueles onde as mulheres tiveram presença predominante, como Odontologia e Psicologia. Conclui-se que as mulheres pretas ainda se encontram em desvantagem em relação às mulheres pardas, e mais ainda em relação às brancas. Percebe-se também que seu cotidiano torna-se extremamente perverso pela atuação dos marcadores gênero, raça e classe, demandando dessas estudantes um esforço adicional para superar o preconceito e a discriminação presentes na sua experiência, particularmente no ambiente universitário.
Application of Dynamic Enhanced MRI image Monitoring and DNA Biosensor in Data Measurement of Ovarian Cancer Using Tofts-Kety Model (Preprint)
Authors: Zhou Yan , Li Hui , Lai Chuntian , Zou Wenda , Zhang Juan
Published: March 2020

UNSTRUCTURED

Based on the Tofts-Kety model, the clinical application value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) monitoring in the data measurement of ovarian cancer is explored, in order to provide more comprehensive measurement information for clinical measurement. In this study, the Tofts-Kety pharmacokinetic model was first established to measure the quantitative parameter volume transfer constant (Ktrans), the inter-plasma rate constant (Kep), and the volume fraction of extravascular extracellular space in unit volume tissue (Ve). 52 patients with routine pelvic floor examination and dynamic contrast-enhanced magnetic resonance imaging (Siemens Magnetom Verio 3.0T superconducting MR) from January 2015 to March 2019 were collected as research subject. The relationship between the parameters of DCE-MRI and the benign and malignant ovarian tumors was analyzed. The operating characteristic curve (ROC) analysis was used to obtain the optimal parameter values and optimal diagnostic thresholds for identifying the benign and malignant ovarian tumors, and the corresponding sensitivity, specificity, positive predictive value and negative predictive value. The results showed that different types of time-signal curve (TIC) had significant statistical significance in the differential measurement of benign and malignant ovarian tumors (P<0.05). The Ktrans, Kep and Ve values of the solid parts of benign and malignant ovarian tumors were statistically significant (P<0.05), it can be known that the measurement limit of the electrode for ovarian cancer SK0V-3 cells is 2.9cell ml-1. The relative standard deviation of the immunosensor is 11.12% after repeated measurement in PBS solution of 0.1mol-1. In summary, DCE-MRI, as a non-invasive imaging technique that can measure information on tumor microcirculation function, has important significance for the differential measurement of benign and malignant tumors.
PENGELOLAAN ARSIP SESUAI STANDAR INTERNASIONAL (ISO 15489-1:2016) STUDI KASUS PENGELOLAAN ARSIP BANK INDONESIA
Authors: Ramudin Riko Priyatmo
Published: March 2020

This article discusses Management of Records that adapts International Standards in the field of archives, namely ISO 15489-1: 2016 on Documentation: Concepts And Principles - Records Management.  Management of Records that compliance with international standards is very important for an organization to create authentic, reliable, complete and usable so that it can support organizational performance. This article is important because until now there is only one institution in Indonesia that applies international standards in the field of records,  Bank Indonesia. The aim is to find out how to manage records in Bank Indonesia that compliance international standards (ISO: 15489-1: 2016). The research method used is a qualitative method with primary and secondary data sources. Bank Indonesia Document Management Policy (MDBI) as a basis for Records Management according to international standards. MDBI refers to the management of records which consists of policies and responsibilities, systems and processes.
KAJIAN LAYANAN ARSIP STATIS BAGI PENGGUNA DIFABEL : STUDI KASUS DINAS KEARSIPAN DAN PERPUSTAKAAN DAERAH X
Authors: Adiningsih Yulia Nur
Published: March 2020

Makalah ini bertujuan untuk mendeskripsikan kegiatan layanan arsip statis bagi pengguna difabel di Dinas Kearsipan dan  Perpustakaan Daerah X. Kajian berfokus pada prosedur layanan arsip statis, dan perwujudan atas ketersediaan serta aksesibilitas layanan. Metode pengumpulan yang digunakan dalam penelitian ini, yaitu kajian pustaka, observasi partisipatif, dan wawancara. Kajian pustaka dilakukan dengan dengan cara membuat catatan dari berbagai referensi seperti buku, jurnal, tugas akhir, skripsi, dan peraturan. Wawancara dilakukan dengan narasumber yang terdiri atas beberapa tingkat pimpinan dan juga pengguna difabel. Observasi partisipatif juga dilaksanakan secara langsung oleh penulis di ruang layanan arsip statis Dinas Kearsipan dan  Perpustakaan Daerah X selama kurun waktu dua bulan. Ada beberapa faktor yang mempengaruhi keberhasilan kegiatan layanan arsip statis bagi pengguna difabel, diantaranya yaitu faktor kebijakan, faktor fasilitas, dan faktor petugas layanan. Untuk aksesibilitas fisik dan aksesibilitas non fisik layanan arsip di Dinas Kearsipan dan Perpustakaan Daerah X secara keseluruhan sudah baik. Namun dinas juga perlu dilengkapi beberapa fasilitas khusus yang belum tersedia bagi pengguna difabel, khususnya tunarungu, tunanetra, dan tunadaksa.
PRELIMINARY STUDY: DISEMINASI PRODUK DOKUMENTASI BUDAYA MELALUI PROYEK MENARA ILMU PUSAT DOKUMENTASI BUDAYA
Authors: Indrasweri Nindya , Wahyuni Elya Riska Dwi , Al Farisy M.Salman
Published: March 2020

This paper aims to describe efforts to disseminate cultural documentation products that have been collected by the Cultural Documentation Center through the Menara Ilmu portal. In the archival perspective, cultural documentation products are an important component for dissemination. The management of cultural documentation products is carried out through the Total Archives approach and the neo-documentation concept. In addition, this study also provides an alternative to the optimization of the dissemination of cultural documentation products through the Culture Documentation Tower Science Project (PDB UGM UGM). The data used in this paper consists of primary data and secondary data. Primary data were collected through non-participation observations by looking at the Menara Menara Pusat cultural documentation and questionnaires with random sampling. The questionnaire was distributed to 100 respondents through Google forms. The conclusion obtained, namely the optimization of dissemination of cultural products can be implemented through "show ads" publication with an internal and external partnership system ". Thus the existence of cultural documentation and archive products can be optimized and can be a promotional event in the field of archives with the concept of virtual exhibition in accordance with the digital era.
“Un editor entre siglos inquiere a la historia del libro en México”. Libros
Authors: Cervantes Becerril Freja I.
Published: March 2020

Reseña de:Libros. Tomás Granados Salinas. Historia Ilustrada de México. México: Secretaría de Cultura, 2017, 208 pp. ISBN: 978-607-745-760-2.
Advertencia editorial
Authors: Giovine Yáñez María Andrea , Godinas Laurette
Published: March 2020

Presentación de la portada, banner y contenido de la sección "Monographia" del presente número de Bibliographica.
Nicholas Rescher, Scientific Explanation
Authors: Padilla Hugo
Published: March 2020

Resumen
El análisis de Platón de las relaciones y de los hechos relacionales en el Fedón
Authors: Castañeda Héctor-Neri
Published: March 2020

Resumen
Russell: el monismo neutral
Authors: Trejo Wonfilio
Published: March 2020

Resumen
Self-Regarding Duties Again
Authors: Rohatyn Dennis Anthony
Published: March 2020

Resumen
Mario Bunge, Method: Model and Matter
Authors: Raggio Andrés R.
Published: March 2020

Resumen
Notas para un esquema de la filosofía de la ciencia contemporánea
Authors: Coffa J. Alberto
Published: March 2020

Resumen
Wittgenstein’s Treatment of Solipsism in the Tractatus
Authors: Pears D.F.
Published: March 2020

Abstract
Algunas observaciones acerca de las relaciones temporales
Authors: Zavalía Teresa de Jesús
Published: March 2020

Resumen
Jerome Hall, Foundations of Jurisprudence
Authors: Esquivel Javier
Published: March 2020

Resumen
Dos décadas de filosofía de la ciencia
Authors: Otero Mario H.
Published: March 2020

Resumen
Semejanza fenoménica
Authors: Shoemaker Sydney
Published: March 2020

Resumen
The Empirical Self: A Reply to Mr. Rohatyn
Authors: Walker Jeremy
Published: March 2020

Resumen
G. Vesey, Personal Identity
Authors: Villanueva Enrique
Published: March 2020

Resumen
The Formalities of Evil
Authors: Walton Douglas
Published: March 2020

Abstract
P.K. Feyerabend, Contra el método
Authors: Battistella Ernesto H.
Published: March 2020

Resumen
Leônidas Hegenberg, Etapas da investigação científica
Authors: Moulines C. Ulises
Published: March 2020

Resumen
Brian E. O’Neil, Epistemological Direct Realism in Descartes’ Philosophy
Authors: Villanueva Enrique
Published: March 2020

Resumen
Confirmation and Extra Information
Authors: Foster Laurence
Published: March 2020

Abstract
Sobre el concepto de ley natural
Authors: Bosch Jorge
Published: March 2020

Resumen
Sobre la explicación probabilística
Authors: Kraiem Ruben
Published: March 2020

Resumen
Samuel Guttenplan (ed.), Mind and Language
Authors: Villanueva Enrique
Published: March 2020

Resumen
Uberto Scarpelli (comp.), Diritto e analisi del linguaggio
Authors: Martino Antonio A.
Published: March 2020

Resumen
Retorno a Hegel
Authors: Villanueva Enrique
Published: March 2020

Resumen
Herbert Morris, On Guilt and Innocence. Essays in Legal Philosophy and Moral Psychology
Authors: Esquivel Javier
Published: March 2020

Resumen
John the Scot (Joannes Scotus Eriugena), Periphyseon: On the Division of Nature
Authors: Beuchot Mauricio
Published: March 2020

Resumen
Negation, Denial and Possibility
Authors: Bryant John
Published: March 2020

Abtract
Milton Goldiner (ed.), Punishment and Human Rights
Authors: Esquivel Javier
Published: March 2020

Resumen
The Gifford Lectures 1972/73, The Development of Mind
Authors: Villanueva Enrique
Published: March 2020

Resumen
Stephen Ellenburg, Rousseau’s Political Philosophy
Authors: Villanueva Enrique
Published: March 2020

Resumen
Normas, imperativos y hechos
Authors: Castañeda Héctor-Neri
Published: March 2020

Resumen
Conferencias CIFINA II
Authors: Beuchot Mauricio
Published: March 2020

Resumen
Condicionales contrafácticos: condiciones de verdad y semántica de mundos posibles. Acerca de las teorías de R. Stalnaker y D. Lewis
Authors: Palau Gladys
Published: March 2020

Resumen
R.S. Peters, Psychology and Ethical Development
Authors: Kolteniuk Miguel
Published: March 2020

Resumen
Observaciones sobre el concepto de aproximación empírica
Authors: Jané Ignacio
Published: March 2020

Resumen
George Pitcher, Berkeley
Authors: Robles José Antonio
Published: March 2020

Resumen
Brian Magee, Men of Ideas
Authors: Robles José Antonio
Published: March 2020

Resumen
La doctrina tomista clásica sobre el signo: Domingo de Soto, Francisco de Araújo y Juan de Santo Tomás
Authors: Beuchot Mauricio
Published: March 2020

Resumen
Douglas Hofstadter, Gödel, Escher, Bach: An Eternal Golden Braid
Authors: Robles J. A.
Published: March 2020

Resumen
Gilbert Harman, The Nature of Morality. An Introduction to Ethics
Authors: Villanueva Enrique
Published: March 2020

Resumen
Prescripciones y normas: la teoría de Castañeda
Authors: Alchourrón Carlos E.
Published: March 2020

Resumen
Robert Almeder, The Philosophy of Charles S. Peirce
Authors: Moulines C. Ulises
Published: March 2020

Resumen
Implicación y verdad deónticas
Authors: Castañeda Héctor-Neri
Published: March 2020

Resumen
Anarchism and Rights Violations
Authors: Sayward Charles
Published: March 2020

Resumen
An Actualist’s Guide to Quantifying In
Authors: Rayo Agustín
Published: March 2020

I develop a device for simulating quantification over merely possible objects from the perspective of a modal actualist---someone who thinks that everything that exists actually exists.
La prueba de Putnam contra el escepticismo radical: dos reinterpretaciones basadas en el autoconocimiento
Authors: Pérez Otero Manuel
Published: March 2020

Presento y defiendo dos reinterpretaciones de la prueba ideada por Putnam para demostrar que no somos cerebros en una cubeta. Ambas resaltan explícitamente el papel desempeñado por el autoconocimiento de nuestros propios pensamientos y por el externismo sobre el contenido. La primera asume que el externismo implica que un cerebro en una cubeta no puede pensar el contenido proposicional relevante (constituido por conceptos acerca de cerebros y cubetas). La otra versión invoca una tesis externista más débil, conforme a la cual un sujeto corpóreo y un cerebro en una cubeta no pueden compartir el contenido proposicional relevante.
Georg Theiner, Res cogitans extensa. A Philosophical Defense of the Extended Mind Thesis
Authors: King Dávalos Patricia
Published: March 2020

Georg Theiner, Res cogitans extensa. A Philosophical Defense of the Extended Mind Thesis, Peter Lang, Fráncfort del Meno, 2011, xiv + 267 pp.
Tyler Burge, Origins of Objectivity
Authors: Vicente Agustín , Vicario Ignacio
Published: March 2020

Tyler Burge, Origins of Objectivity, Oxford University Press, Oxford, 2010, 656 pp.
Marxismo, autopropiedad y abundancia
Authors: Lizárraga Fernando A.
Published: March 2020

G.A. Cohen y John Rawls atribuyen a Karl Marx haberse adherido al principio libertarista de autopropiedad y una plena confianza en la abundancia ilimitada como solución a los defectos distributivos del socialismo. Asimismo, consideran que el comunismo marxiano está, en cierto sentido, más allá de la justicia. Contra estas posiciones, veremos que Marx rechaza la autopropiedad en términos normativos, que la predicción de plenitud material no es estrictamente marxiana, y que la doble valoración del comunismo —a la vez justo y más allá de la justicia— no es totalmente consistente.
Alberto Moretti, Interpretar y referir: ejercicios de análisis filosófico
Authors: Orlando Eleonora
Published: March 2020

Alberto Moretti, Interpretar y referir: ejercicios de análisis filosófico
Expresabilidad, validez y recursos lógicos
Authors: Barrio Eduardo Alejandro
Published: March 2020

El objetivo de este artículo es investigar diversos resultados limitativos acerca del concepto de validez. En particular, argumento que ninguna teoría lógica de orden superior con semántica estándar puede tener recursos expresivos suficientes como para capturar su propio concepto de validez. Además, muestro que la lógica de la verdad transparente que Hartry Field desarrolló recientemente conduce a resultados limitativos similares.
Creencia de primera persona, conciencia y la paradoja de Eroom
Authors: Vidal Javier
Published: March 2020

En este artículo se trata de mostrar que existe una relación necesaria, no contingente, entre tener una creencia de primera persona y creer conscientemente: una creencia de primera persona es necesariamente consciente. Pero de aquí se siguen al menos dos importantes consecuencias. Primero, tendría que ser abandonada una teoría de la conciencia según la cual un estado mental es consciente cuando va acompañado por un pensamiento o una creencia de orden superior acerca de ese estado. Segundo, podría darse cierta explicación de la paradoja de Eroom, que es el sinsentido de aseverar o de creer algo de la forma “py yo creo inconscientemente que p”.
Doing One’s Best, Alternative Possibilities, and Blameworthiness
Authors: Moya Carlos J.
Published: March 2020

My main aim in this paper is to improve and give further support to a defense of the Principle of Alternative Possibilities (PAP) against Frankfurt cases which I put forward in some previous work. In the present paper I concentrate on a recent and famous Frankfurt case, Derk Pereboom’s “Tax Evasion”. After presenting the essentials of my defense of PAP and applying it to this case, I go on to consider several objections that have been (or might be) raised against it and argue that they don’t succeed. I conclude by pointing out that my criticism of Pereboom’s example suggests a general strategy against other actual or possible Frankfurt cases.
Against Artifactual Epistemic Privilege
Authors: Verdejo Víctor M.
Published: March 2020

The deep intentional roots of artifacts and artifactual kinds seem to give intuitive as well as philosophical support to a form of epistemic privilege for makers regarding the objects they create. In this paper, I critically examine the thesis of epistemic privilege for artifact creators and present a counterexample based on anti-individualism. Several objections to the counterexample are considered and responded to. I conclude that, if anti-individualism is true, then the alleged epistemic privilege of creators of artifacts is either false or an explanatorily idle label. I argue, finally, that even if anti-individualism forces us to reject epistemic privilege for artifact kinds, these kinds may exhibit metaphysical and semantic mind-dependence, something that would keep them still distinctly apart from natural kinds and leave their essentially intentional nature untouched.
Agustín Rayo, The Construction of Logical Space
Authors: Burgess Alexis
Published: March 2020

Agustín Rayo, The Construction of Logical Space, Oxford University Press, Oxford, 2013, 220 pp.
Una propuesta modal sobre la T-Teoricidad y el papel de los postulados y axiomas en la teorías científicas
Authors: Dahlquist Manuel , Gonzálo Adriana
Published: March 2020

El denominado "problema de los términos teóricos" que inicialmente  formuló Sneed (1971) surge de la interpretación que de los términos teóricos hace  la concepción  heredada. Esta lectura no se condice con la interpretación indirecta de los términos teóricos que Carnap realiza (1937, 1939) al utilizar postulados. Estos textos proponen  una interpretación holística de las teorías científicas, sólo adecuadamente tratada es una semántica de mundos posibles. Andreas (2008, 2010) proporciona un tratamiento modal de los términos teóricos; nosotros presentamos estos resultados en términos de modelos de Kripke; luego  los extendemos con el din de que sean capaces de ditinguir entre axiomas y oraciones teóricas, generando un modelo capaz de tratarlos de manera diferenciada  y que aporte nuevos resultados lógicos y filosóficos.
Racionalidad y acción no reflexiva. El debate Dreyfus-McDowell
Authors: Hernandez Betancur Juan Pablo
Published: March 2020

El debate reciente iniciado por Hubert Dreyfus y John McDowell ha llamado la atención sobre la relación entre racionalidad y acción no reflexiva. En este artículo propongo una forma de especificar el desacuerdo entre quienes llamaré intelectualistas y antiintelectualistas. A la luz de esta propuesta arguyo que el principal argumento antiintelectualista sólo tiene éxito si se acepta al menos uno de tres presupuestos implícitos que están lejos de ser autoevidentes y cuya verdad es puesta en duda por fenómenos familiares. Termino con consideraciones que sugieren que el intelectualista ha quedado en una mejor posición argumentativa.
Kripke on Functionalism
Authors: Burgess John P.
Published: March 2020

Saul Kripke’s still largely unpublished views on functionalism in the philosophy of mind are expounded on the basis of a transcript of a 1984 lecture of his on the topic, and some unresolved questions identified.
El problema de las clases naturales en química: algunas dificultades para el microestructuralismo
Authors: Martínez González Juan Camilo , Córdoba Mariana
Published: March 2020

Nuestro propósito es trastornar el tratamiento habitual del problema de las clases naturales en filosofía de la ciencia, analizándolo sincrónicamente y poniendo la química en el foco. Analizaremos tres problemas que la disciplina presenta almicroesencialismo: (1) la insuficiencia del número atómico como propiedad y criterio esencial, (2) la imposibilidad de la mecánica cuántica de dar cuenta de la estructura molecular y, por consiguiente, de importantes propiedades macroscópicas de las sustancias, (3) la imposibilidad de definir propiedades centrales, como la acidez, a partir de las propiedades microscópicas. Argumentaremos que, sin embargo, cabe mantener la noción de clase natural en química, pero reformulándola desde la perspectiva del realismo activo y el pluralismo ideológico de Hasok Chang. Esta propuesta permite pensar que si bien las clasificaciones no deben ser interpretadas en un sentido esencialista, no son arbitrarias ni meramente convencionales, porque la realidad puede hacer fracasar un sistema de clasificación y dar éxito a otro.
Sutton’s Solution to The Grounding Problem and Intrinsically Composed Colocated Objects
Authors: Campdelacreu Marta
Published: March 2020

In Sutton 2012, Catherine Sutton offers a new and very interesting solution to the most challenging problem facing colocationism: the grounding problem. However, if I am right in rejecting her thesis that lumps or pieces of matter are extrinsically composed, then her proposal is no longer a complete answer to the grounding problem, and it is difficult to see how it might be supplemented.
A Reply to Céspedes’ Defense of Causal Contrastivism
Authors: Steglich-Petersen Asbjørn
Published: March 2020

In a recent article in this journal, Esteban Céspedes (2015) seeks to defend the contrastive account of singular causation from my criticisms (Steglich-Petersen 2012). Céspedes objects to my argument on three counts: (1) it is circular in presupposing a principle that it seeks to establish; (2) that same principle is false; and (3) even if the principle were true, it would not speak against the contrastive account. In this note I argue that all three objections are unconvincing.
Jerry A. Fodor y Zenon W. Pylyshyn, Minds without Meanings. An Essay on the Content of Concepts
Authors: Mota Sergio , Igoa José Manuel
Published: March 2020

Jerry A. Fodor y Zenon W. Pylyshyn, Minds without Meanings. An Essay on the Content of Concepts, MIT Press, Cambridge, Mass., 2015, 193 pp.
Why General Jurisprudence Is Interesting
Authors: Dickson Julie
Published: March 2020

In a recent article entitled, “Is General Jurisprudence Interesting?”, David Enoch answers his own question resoundingly in the negative. This article critically examines the character of Enoch’s claim, the presuppositions it rests on, and the way in which he seeks to establish it. Having argued that many of Enoch’s views in this regard hinge on a narrow and idiosyncratic understanding of the questions that general jurisprudence addresses, and of the relations between those questions and many other inquiries concerning the character of law, the article concludes by offering its author’s own vision of what makes general jurisprudence engaging, intriguing, and. . . well. . . interesting.
Down The Methodological Rabbit Hole
Authors: Frydrych David
Published: March 2020

This article surveys methodological matters that shape, drive, and plague analytic legal philosophy. Section 2 briefly explicates conceptual analysis, analytic definitions, and family resemblance concepts. It also argues that central cases are used in more than one way. Section 3 presents criticisms of those concepts and methods, and suggests that some of these difficulties are due to the lack of a shared paradigm regarding a counterexample’s impact. Section 4 explains “metatheoretical” desiderata. It contends that, to date, legal philosophical appeals to such norms have not been as helpful as some suggest. Section 5 returns to the issue of concept selection by addressing whether legal theorising is an invariably “normative” enterprise. It argues that certain “normativist” methodologies, such as Dworkin’s constructive interpretation and Finnis’ appeal to the central case of the internal point of view, are unnecessary.
Detached Statements
Authors: Mcbride Mark
Published: March 2020

Joseph Raz has introduced an interesting class of statements —detached statements— into the philosophical lexicon. In brief, such statements are (informative) normative statements, yet the speaker does not, in so uttering them, express or convey acceptance of the point of view of the hearer to whom they are addressed (as contrasted with committed statements, where the speaker does express or convey such acceptance). I propose to offer a novel analysis of such statements (and to clear away some confusions about them). In brief, such statements will be analysed as wide-scope normative conditionals.
Commanding and Defining. On Eugenio Bulygin’s Theory of Legal Power-Conferring Rules
Authors: Villa Rosas Gonzalo
Published: March 2020

This paper aims to explore two objections raised against Bulygin’s second approach to the definition of the nature of legal power-conferring rules. According to the first objection, such an account is vague about what is defined by legal powerconferring rules qua constitutive rules. I maintain that this vagueness is rooted in the lack of a suitable definition of legal power. I shall be arguing for the reduction of the complexity of the definientia by defining legal power as a species of competence. According to the second objection, this non-reductive approach cannot explain the normativity of this kind of rules. Against this approach, it argues that legal powerconferring rules perform a deontic and a definitional function as constitutive rules of legal practice.
On Some Objections to The Deductive Closure of Legal Systems
Authors: Zuleta Hugo R.
Published: March 2020

I criticize an argument presented by Pablo Navarro and Jorge Rodríguez (2014) against the conception of legal systems as sets of statements closed under logical consequence. First, I show that the example on which they ground their argument incurs in a fallacy of equivocation. Then, I recognize that the authors are right about the fact that two different normative bases can react differently to changes, but I claim that that is not a decisive reason for choosing always the expressly enacted norms as the system’s basis, that the selection of the best basis should be guided by methodological considerations and that, to that purpose, it is necessary to consider the whole set of logical consequences as part of the system.
Against Phenomenal Externalism
Authors: Sacchi Elisabetta , Voltolini Alberto
Published: March 2020

We maintain that no extant argument in favor of phenomenal externalism (PE) is really convincing. PE is the thesis that the phenomenal properties of our experiences must be individuated widely insofar as they are constituted by worldly properties. We consider what we take to be the five best arguments for PE. We try to show that none of them really proves what it aims at proving. Unless better arguments in favor of phenomenal externalism show up in the debate, we see noreason to relinquish an idea that seems intuitive and appeals to many cognitive scientists: that phenomenology is narrow, i.e., that phenomenal properties are intrinsic properties of our experiences. This idea grounds the opposite philosophical position, phenomenal internalism (PI).
Las normas y su puesta en vigor: respuesta a Josep Corbí
Authors: García-Carpintero Manuel
Published: March 2020

En su discusión “Obras de ficción, formas de conciencia y literatura”, Josep Corbí formula una serie de críticas certeras a mis ideas sobre la distinción que he hecho entre ficción y no ficción en Relatar lo ocurrido como invención (2016). En esta nota de respuesta expongo primero de forma sucinta el núcleo de esas ideas y después proporciono las que considero las razones más decisivas para adoptarlas, a pesar de las dificultades que señala Corbí
Carlos Montemayor, Minding Time: A Philosophical and Theoretical Approach to the Psychology of Time
Authors: Merino-Rajme Carla
Published: March 2020

Carlos Montemayor, Minding Time: A Philosophical and TheoreticalApproach to the Psychology of Time, Brill, Leiden, 2013, xiv +154 pp.
El foro invertido en la movilización del conocimiento: alcances e implicaciones
Authors: Diez Elieth , Del Fiaco Zuly , Castellano Alberto , Ordoñez Luis
Published: March 2020

Este artículo sintetiza los alcances y las implicaciones del foro invertido Movilización del conocimiento entre Universidad y Sociedad, desarrollado por la Fundación InterConectados (Venezuela). Este foro, inspirado en la clase invertida, es una estrategia apoyada en las TIC, concebido como un espacio para gestionar y movilizar conocimiento e información, producto de tareas investigativas donde se promueve la colaboración y la interacción, con la pretensión de configurar nuevas ecologías de aprendizaje. Se realizó una revisión documental sobre gestión y movilización del conocimiento, enfoque invertido en educación, TIC y foros académicos. El enfoque fue vivencialista-experiencialista, mediante el método fenomenológico. A partir de un muestreo intencional, se recolectó la información a través de dos técnicas, como parte del proceso de triangulación: la entrevista semi-estructurada con 2 informantes clave que participaron en varios foros y un cuestionario de preguntas abiertas aplicado a 14 informantes clave. Tras un análisis cualitativo, los hallazgos mostraron mayor alcance e implicación del foro invertido en la dimensión social, pero también en lo educativo y organizacional; esta última recibió una valoración positiva, al dejar en claro la necesidad de mejorar aspectos relacionados con la estructura y el funcionamiento para la optimización del foro.
Reseña del libro Estar, ser y convivir en la escuela: una mirada profunda a la violencia escolar en República Dominicana
Authors: López Altagracia
Published: March 2020

No precisa de un resumen.
A Linguistic Analysis of Petroleum-Related English Research Article Titles
Authors: Filyasova Yulia A.
Published: March 2020

Research article titles constitute a special type of text - concise, clear, and informative. The specificity of article titles is determined by a number of factors such as the object of research, the author’s personal style, academic tradition, the field of study among them. Today, article titles from different scientific areas are in the focus of scientific attention. This article presents the results of a linguistic analysis aimed at determining similarities and differences of research article titles from journals on petroleum science. The theoretical value has the descriptive analysis of technical article titles which can further be compared with titles from other areas of research. According to the obtained results, the titles were 15 words on average. The overwhelming majority (98%) of the titles had a nominative character; 2% were subject-predicate sentences, mainly, interrogative. Words were seven characters long, on average. Nouns, function words and adjectives were the most frequently occurred word classes; on the contrary, numerals, adverbs and verbs - the least frequent words. The most common punctuation marks were hyphens, commas, and colons, indicating the complexity of technical terms, enumeration and elaboration of the object of research and geography of petroleum sites. Names of petroleum reservoirs, formations and basins with their location specification, multisyllabic professional terms and abbreviations, constituting 30% of the article titles’ lengths on the average, can be considered special features of article titles on petroleum science. For this reason, a long title is typical of petroleum-related research articles. Additionally, more articles were devoted to richer petroleum reserves.
On Asymptotics of the Density of States for Hypoelliptic Almost Periodic Systems
Authors: Bezyaev V. I.
Published: March 2020

In this paper, we find the asymptotics of integrated density of states with remainder estimate for hypoelliptic systems with almost periodic (a.p.) coefficients. We use the approximate spectral projector method for matrix a.p. operators with continuous spectrum.
Getting It Off the Ground: Key Factors Associated With Implementation of Wellness Programs
Authors: Penwell-Waines Lauren , Cronholm Peter F. , Brennan Julie , Romain Amy , Runyan Christine , Buck Katherine , Fazio Lindsay , Grace Aaron , Ricker Mari , Ross Valerie , Schneiderhan Jill , Talen Mary
Published: March 2020

Background and Objectives: Many residency programs are developing resident wellness curricula to improve resident well-being and to meet Accreditation Council for Graduate Medical Education guidelines. However, there is limited guidance on preferred curricular components and implementation. We sought to identify how specific driving factors (eg, having an identified wellness champion with a budget and protected time to develop wellness programs) impact implementation of essential elements of a resident wellness curriculum.
Methods: We surveyed 608 family medicine residency program directors (PDs) in 2018-2019 on available resources for wellness programs, essential wellness elements being implemented, and satisfaction with wellness programming; 251 PDs provided complete responses (42.5% response rate). Linear and logistic regressions were conducted for main analyses.
Results: Having an identified wellness champion, protected time, and dedicated budget for wellness were associated with greater implementation of wellness programs and PD satisfaction with wellness programming; of these, funding had the strongest association. Larger programs were implementing more wellness program components. Program setting had no association with implementation.
Conclusions: PDs in programs allocating money and/or faculty time can expect more wellness programming and greater satisfaction with how resident well-being is addressed.
Optimization of the simultaneous production of cellulase and xylanase by submerged and solid-state fermentation of wheat chaff
Authors: Jovanovic Mirjana , Vucurovic Damjan , Bajic Bojana , Dodic Sinisa , Vlajkov Vanja , Jevtic-Mucibabic Rada
Published: March 2020

Wheat chaff as an agricultural waste represents a cheap raw material for biotechnological processes. With its lignocellulosic composition, it is suitable for producing hydrolytic enzymes for second generation renewable fuel production technologies. The aim of this work was to optimize the process parameters (cultivation temperature 25?35?C, pH value 4?6 and cultivation time 3?7 days) of the cultivating fungi (Trichoderma reesei QM 9414) on a media based on wheat chaff by submerged and solid-state techniques, in order to enhance and compare the two types of simultaneous cellulase and xylanase production. Optimal conditions for the submerged fermentation were 29.65?C for temperature, pH 4.27 and 7 days of cultivation, while for the solid-state fermentation, the optimal conditions were 28.01?C, pH 6.00 and 7 days. The cellulolytic and xylanolytic activities of the obtained cultivation broth filtrates were 0.0535 and 0.1676 U mL-1 for the submerged fermentation, and 0.0407 and 0.1401 U mL-1 for the solid-state fermentation, respectively, and with a 26.77 and 13.39 % enhancement of enzyme activity for submerged fermentation, and a 22.96 and 42.66 % enhancement for solid-state fermentation, respectively, compared to the results obtained before optimization.
Activation of Retinal Angiogenesis in Hyperglycemic pdx1
−/− Zebrafish Mutants
Authors: Wiggenhauser Lucas M. , Qi Haozhe , Stoll Sandra J. , Metzger Lena , Bennewitz Katrin , Poschet Gernot , Krenning Guido , Hillebrands Jan-Luuk , Hammes Hans-Peter , Kroll Jens
Published: March 2020

Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic pdx1−/− zebrafish mutant as a model for diabetic retinopathy that lacks the transcription factor pdx1 through CRISPR-Cas9–mediated gene knockout leading to disturbed pancreatic development and hyperglycemia. Larval pdx1−/− mutants prominently show vasodilation of blood vessels through increased vascular thickness in the hyaloid network as direct developmental precursor of the adult retinal vasculature in zebrafish. In adult pdx1−/− mutants, impaired glucose homeostasis induces increased hyperbranching and hypersprouting with new vessel formation in the retina and aggravation of the vascular alterations from the larval to the adult stage. Both vascular aspects respond to antiangiogenic and antihyperglycemic pharmacological interventions in the larval stage and are accompanied by alterations in the nitric oxide metabolism. Thus, the pdx1−/− mutant represents a novel model to study mechanisms of hyperglycemia-induced retinopathy wherein extensive proangiogenic alterations in blood vessel morphology and metabolic alterations underlie the vascular phenotype.