bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantifying the locality of the food supply in a large healthcare organisation
Authors: Utter Jennifer , Mole Frances , Johnston Henrietta , McCray Sally
Published: August 2024

Aim

Shocks to the food system (such as extreme weather events, wars, and pandemics) are felt by institutional food systems. For hospitals, these shocks affect the quantity, quality, and variety of foods that can be offered to patients. One strategy to buffer the hospital food supply from external threats is to prioritise ingredients produced locally. Thus, the aim of the current research is to describe the country of origin of all foods purchased by a large, metropolitan healthcare organisation and to identify opportunities for improving the locality of the food supply.

Methods

This study was of a cross‐sectional, observational design. The country of origin for all foods procured over a 1‐year period by a large, urban healthcare organisation was determined by proportion of food budget spend. State of origin was identified for fresh fruit, vegetables, and meat. The organisation was in Queensland, Australia and utilised a cook‐fresh, room‐service foodservice model. Descriptive analysis was used to to determine the number of items and the proportion of budget spend on all foods produced in Australia, and by food category. Similar descriptive statistics were generated to determine the proportion of the budget spend on fresh fruits, vegetables and meats produced in Queensland.

Results

Over the 1‐year period, 659 individual food items were purchased by the hospital foodservice, and 502 food items were included in the anlaysis. In total, 53% of the food budget was spent on Australian foods (100% Australian ingredients) and almost all fruit (73%) and vegetables (91%) were Australian grown. Procuring fresh fruit (28%), vegetables (35%), and meat (46%) from within the state was less common, and this may reflect the primary states of production across Australia, and seasonal variability of the food supply.

Conclusions

Findings offer priority areas for improving the locality of the food supply. Future research to determine if procuring more foods locally has benefits to consistency of the food supply is warranted.
Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence
Authors: Novo João P. , Gee Lucy , Caetano Carolina A. , Tomé Inês , Vilaça Andreia , von Zglinicki Thomas , Moreira Irina S. , Jurk Diana , Rosa Susana , Ferreira Lino
Published: August 2024

BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
Loss of immune cell identity with age inferred from large atlases of single cell transcriptomes
Authors: Connolly Erin , Pan Tony , Aluru Maneesha , Chockalingam Sriram , Dhere Vishal , Gibson Greg
Published: August 2024

By analyzing two large atlases of almost 4 million cells, we show that immune‐senescence involves a gradual loss of cellular identity, reflecting increased cellular heterogeneity, for effector, and cytotoxic immune cells. The effects are largely similar in both males and females and were robustly reproduced in two atlases, one assembled from 35 diverse studies including 678 adults, the other the OneK1K study of 982 adults. Since the mean transcriptional differences among cell‐types remain constant across age deciles, there is little evidence for the alternative mechanism of convergence of cell‐type identity. Key pathways promoting activation and stemness are down‐regulated in aged T cells, while CD8 TEM and CD4 CTLs exhibited elevated inflammatory, and cytotoxicity in older individuals. Elevated inflammatory signaling pathways, such as MAPK and TNF‐alpha signaling via NF‐kB, also occur across all aged immune cells, particularly amongst effector immune cells. This finding of lost transcriptional identity with age carries several implications, spanning from a fundamental biological understanding of aging mechanisms to clinical perspectives on the efficacy of immunomodulation in elderly people.
Using machine learning to explore the predictors of life satisfaction trajectories in older adults
Authors: Chen Honghui , Zhang Xueting , Bian Wenjun
Published: August 2024

Life satisfaction is vital for older adults' well‐being, impacting various life aspects. It is dynamic, necessitating nuanced approaches to capture its trajectories accurately. This study aimed to explore the diverse trajectories and predictors of life satisfaction among older adults in China using longitudinal data from the China Health and Retirement Longitudinal Study. Latent class growth modeling and growth mixture modeling were employed to identify distinct trajectories of life satisfaction. Machine learning (ML) models were developed to predict different trajectories and identify important predictors of different trajectories. Four distinct trajectories of life satisfaction were identified, showcasing nuanced patterns of life satisfaction that changed over time. ML models, especially random forest, effectively predicted these trajectories. Emotional experiences (particularly the frequency of happiness and loneliness), body mass index, and self‐report health emerged as significant predictors of different life satisfaction trajectories. Our finding revealed the importance of focusing on individuals or groups with consistently low life satisfaction and paying more attention to mental and physical health predictors. Our models might guide future targeted preventative treatments.
International consensus definitions for infection‐triggered encephalopathy syndromes
Authors: Sakuma Hiroshi , Thomas Terrence , Debinski Carly , Eyre Michael , Han Velda X. , Jones Hannah F. , Kawano Go , Lee Vanessa W. , Malone Stephen , Matsuishi Toyojiro , Mohammad Shekeeb S. , Mori Takayuki , Nishida Hiroya , Nosadini Margherita , Takanashi Jun‐ichi , Mizuguchi Masashi , Lim Ming , Dale Russell C.
Published: August 2024

Aim

To develop standardized diagnostic criteria for ‘infection‐triggered encephalopathy syndrome (ITES)’ and five specific clinical syndromes of ITES.

Method

The draft definitions were based on existing criteria, standardized, and discussed by a panel of international experts using nominal group technique over 18 months to achieve consensus. All criteria use the same format: (1) presence of infection/fever; (2) clinical features including encephalopathy; (3) neuroradiological features on magnetic resonance imaging; (4) exclusion of other causes.

Results

We first highlighted differences between ITES and infectious and autoimmune encephalitis, which is the most important differential diagnosis. Consensus was achieved to define five specific ITESs: acute encephalopathy with biphasic seizures and late reduced diffusion; acute necrotizing encephalopathy; mild encephalopathy with a reversible splenial lesion; acute fulminant cerebral oedema; and acute shock with encephalopathy and multiorgan failure. Two further conditions that are currently classified as epilepsy syndromes but have similar features to ITES, namely febrile infection‐related epilepsy syndrome and hemiconvulsion–hemiplegia–epilepsy syndrome, are also discussed.

Interpretation

The consensus definition is expected to improve awareness of this disease concept, provide diagnostic framework, and facilitate future international research and clinical trials.
Motor interference on lateral pelvis shifting towards the paretic leg during walking and its cortical mechanisms in persons with stroke
Authors: Lim Hyosok , Yan Shijun , Dee Weena , Pech Velarie , Hameeduddin Iram , Roth Elliot J. , Rymer William Z. , Wu Ming
Published: August 2024

Motor interference, where new skill acquisition disrupts the performance of a previously learned skill, is a critical yet underexplored factor in gait rehabilitation post‐stroke. This study investigates the interference effects of two different practice schedules, applying interleaved (ABA condition) and intermittent (A‐A condition) pulling force to the pelvis during treadmill walking, on lateral pelvis shifting towards the paretic leg in individuals with stroke. Task A involved applying resistive pelvis force (pulling towards the non‐paretic side), and Task B applied assistive force (pulling towards the paretic side) at the stance phase of the paretic leg during walking. Sixteen individuals with chronic stroke were tested for gait pattern changes, including lateral pelvis shifting and spatiotemporal gait parameters, and neurophysiological changes, including muscle activity in the paretic leg and beta band absolute power in the lesioned cortical areas. A‐A condition demonstrated increased lateral pelvis shifting towards the paretic side, extended paretic stance time and longer non‐paretic step length after force release while ABA condition did not show any changes. These changes in gait pattern after A‐A condition were accompanied by increased muscle activities of the ankle plantarflexors, and hip adductors/abductors. A‐A condition demonstrated greater changes in beta band power in the sensorimotor regions compared to ABA condition. These findings suggest that while walking practice with external force to the pelvis can improve lateral pelvis shifting towards the paretic leg post‐stroke, practicing a new pelvis shifting task in close succession may hinder the performance of a previously obtained lateral pelvis shifting pattern during walking.
Immunology in Practice: a modular framework to support Master of Science students conference attendance and engagement
Authors: Trela Malgorzata , Rutschmann Sophie
Published: August 2024

Sharing a passion for the advancement of the discipline, the scientific community provides an authentic environment for new members to acquire the knowledge and develop the professional identity needed for their future careers. Supporting opportunities for higher education students to participate in this community can complement their classroom‐based education and be extremely beneficial to their learning. Situated in the authentic environment of the scientific community, conferences are organized events where professionals meet to advance their discipline, and which have been shown to provide unique learning opportunities for university students. Here we present a modular framework created to support Imperial College London's Master of Science in Immunology students’ attendance at the British Society for Immunology Annual Congress. The module's evaluation indicates an overall students’ satisfaction with the content, organization, teaching, assessment, feedback and community aspects of the framework and draws attention to areas of potential improvements. Furthermore, the data emphasize the importance of preconference preparation, of academic mentoring and discusses the role of peer support. Finally, the data highlight the benefits for students of discovering the true breadth and depth of their discipline, of interacting with members of the community and how these contribute to the development of their professional identity.
Can information and communication technology drive effective spatial governance in rural areas? Emergency of e‐participation ecosystem from rural China
Authors: Tong Lei , Ji Haotian , Zhang Hua , Chen Lingxi , Cheng Xiaojuan
Published: August 2024

The integration of Information and Communication Technology (ICT) in rural areas holds significant potential for facilitating active participation of villagers in spatial governance processes. While previous research has primarily focused on the role of e‐participation tools in rural governance, there exists a knowledge gap regarding substantive villager participation within intricate systems. This study explores the intricate mechanism of meaningful engagement by harnessing the potential of ICT and parametric technologies. First, the concept of ‘e‐participation ecosystem’ is proposed. The concept integrates ICT, parametric technology and other relevant elements necessary to facilitate substantial participation of rural villagers in spatial governance. Subsequently, an analytical framework to examine the impact mechanism of ICT technology on the efficiency of village spatial governance is developed, building upon an evaluation of villagers' active involvement. Finally, a practical demonstration was conducted in C village to validate the positive impact of ICT on rural spatial governance. This study reveals that the successful implementation of ICT in village spatial governance necessitates a comprehensive ‘e‐participation ecosystem’ for support, as the efficacy of individual ICT technologies is limited. Additionally, it highlights that the utilisation of ICT can enhance efficiency in village spatial governance, thereby reducing participation costs for all stakeholders through a streamlined governance process. Moreover, parameterization technology plays an equally crucial role in the process of village spatial governance. By harnessing the power of parameterization technology, the efficiency of generating village spatial planning schemes can be significantly enhanced. When integrated with ICT technology, it has the potential to substantially reduce response time for all stakeholders involved.
Why it Can Be Permissible to Have Kids in the Climate Emergency
Authors: Cripps Elizabeth
Published: August 2024

Having a child is one of the highest‐carbon decisions made by affluent individuals. Does this uncomfortable fact mean they should limit biological family size? This salient question also forces attention to two key issues. One is just how demanding individual climate justice duties are. The other is the danger of ‘ivory tower’ reasoning by privileged philosophers. On some topics, it is imperative carefully to integrate philosophical discussion with sociological and psychological research. Assuming individual climate justice duties include cutting one's carbon impact, the discussion goes as follows. Should affluent couples and individuals have no biological children, because of the carbon cost? Not unless emissions‐cutting duties are extremely demanding, or we make dangerous, generalised socio‐psychological assumptions. Is there any individual duty to consider carbon impact when determining family size? Yes, because individual emissions‐cutting duties are more than trivially demanding. Should all duty‐bearers ‘stop at’ some fixed maximum number of biological kids? Not unless that number is one and we are prepared to accept very demanding individual emissions‐cutting duties and make problematic sociological assumptions. Finally, the article outlines three further individual duties following from the ‘uncomfortable fact’: to raise good climate citizens, become activists, and cut the family carbon footprint.
Novice interpreters, transmedia fictions and the afferent stance
Authors: Mackey Margaret
Published: August 2024

Louise Rosenblatt's well‐known concept of stance distinguishes between efferent reading (reading to take something away from the text) and aesthetic reading (reading for the experience of dwelling in the text). This article proposes a refinement to this binary, adding the concept of afferent reading. Afference, in biology, means a bringing‐to, and afferent reading includes what interpreters bring to a text. This article particularly considers how afference works in a world of transmedia iterations of a story. What do young readers bring to their interpretation of a version of a story from other versions of the same story or the same story world? How does the concept of afference improve the ability of teachers and other adult observers to consider different renditions of the same story as a potential asset to young interpreters rather than simply a form of repetition?
Megaconial congenital muscular dystrophy: Importance of cutaneous features and successful response to ustekinumab
Authors: Palacios‐Diaz Rodolfo David , Pozuelo‐Ruiz Mónica , Martínez‐Castellano Francisco , Évole‐Buselli Montserrat
Published: August 2024

Megaconial congenital muscular dystrophy (MCMD) is a rare autosomal‐recessive multisystem disorder characterized by delayed motor development, intellectual disability, and skin involvement. We report a patient with MCMD who had diffuse ichthyosis‐like scaling, and successfully responded to ustekinumab.
Curvature varifolds with orthogonal boundary
Authors: Kuwert Ernst , Müller Marius
Published: August 2024

We consider the class of ‐dimensional surfaces in that intersect orthogonally along the boundary. A piece of an affine ‐plane in is called an orthogonal slice. We prove estimates for the area by the integral of the second fundamental form in three cases: first, when admits no orthogonal slices, second for if all orthogonal slices are topological disks, and finally, for all if the surfaces are confined to a neighborhood of . The orthogonality constraint has a weak formulation for curvature varifolds. We classify those varifolds of vanishing curvature. As an application, we prove for any the existence of an orthogonal 2‐varifold that minimizes the curvature in the integer rectifiable class.
A fibre-optic ultrasound sensor of simple fabrication
Authors: Shagroun Fadwa , Colchester Richard James , Alles Erwin Jozef
Published: August 2024

The small size, high sensitivity, and immunity to electromagnetic interference of fibre-optic ultrasound sensors make them highly attractive for applications in biomedical imaging and metrology. Typically, such sensors rely on optically resonant structures, such as Fabry–Perot cavities, that require elaborate fabrication techniques. Here, an alternative fibre-optic ultrasound sensor is presented that comprises a simple deformable and reflective structure that was deposited using simple dip-coating. Interrogation with a laser Doppler vibrometer demonstrated how this sensor achieved a sensitivity, signal-to-noise ratio, and noise-equivalent pressure that outperformed piezoelectric hydrophones, whilst offering a highly miniature form factor, turn-key operation, and simple fabrication.
Spatial domain dedispersion transform and its application extracting horizontal wavenumber structure
Authors: Zhang Hongchen , Zhou Shihong , Liu Changpeng , Qi Yubo
Published: August 2024

Dispersion and multipath effects contribute to the complexity of the shallow water acoustic field. However, this complexity contains valuable information regarding both the waveguide and the acoustic source. The horizontal wavenumber and relative amplitude of the modes comprising the acoustic field are crucial pieces of information for addressing acoustic inversion problems in shallow water. However, when employing a horizontal array to extract this information, limitations arise due to array aperture and signal-to-noise ratio constraints. To attempt to solve these challenges, the approach of spatial domain dedispersion transform and frequency domain accumulation is proposed. The objective can be attained by leveraging broadband source with slowly varying phase spectrum or known phase spectrum under the constraints of small aperture arrays and low signal-to-noise ratio. Additionally, the approach is validated on dual-hydrophone horizontal array by relaxing the signal-to-noise ratio requirement. In this paper, theoretical proof of the algorithms' performance is provided, accompanied by analysis of the impact of parameters such as acoustic source bandwidth, the number of elements and array aperture. The effectiveness of the algorithms are validated through simulations and experimental data.
Mapping safe drinking water use in low- and middle-income countries
Authors: Greenwood Esther E. , Lauber Thomas , van den Hoogen Johan , Donmez Ayca , Bain Robert E. S. , Johnston Richard , Crowther Thomas W. , Julian Timothy R.
Published: August 2024

Safe drinking water access is a human right, but data on safely managed drinking water services (SMDWS) is lacking for more than half of the global population. We estimate SMDWS use in 135 low- and middle-income countries (LMICs) at subnational levels with a geospatial modeling approach, combining existing household survey data with available global geospatial datasets. We estimate that only one in three people used SMDWS in LMICs in 2020 and identified fecal contamination as the primary limiting factor affecting almost half of the population of LMICs. Our results are relevant for raising awareness about the challenges and limitations of current global monitoring approaches and demonstrating how globally available geospatial data can be leveraged to fill data gaps and identify priority areas in LMICs.
Biospecimen research and the law
Authors: Dye Timothy D. , Menikoff Jerry A.
Published: August 2024

In the well-known case of Henrietta Lacks, cells from her tumor were taken without consent and used more than 70 years ago to create the first immortal human cell line (“HeLa” cells). That event led to many scientific breakthroughs and to the debate about the ethics of consent and requirements for compensation. May 2024 saw two decisions by US federal courts—one related to Lacks—that could narrow the scope of research allowed on tissues obtained without consent and on nonidentified tissues, with implications for biomedicine.
In Other Journals
Authors: Jiang Di , McCartney Melissa , Osborne Ian S. , Hurtley Stella M. , Sofowora Iyinoluwa , Ross Sarah H. , Nusinovich Yevgeniya
Published: August 2024

Editors’ selections from the current scientific literature
Troubled waters
Authors: Attride Dawn
Published: August 2024

In an iconic corner of the Grand Canyon, a uranium mine may threaten a tribe’s sole water source
Endovascular embolisation of a traumatic pseudoaneurysm of the lateral perforating peroneal artery
Authors: Ishak Myrna , Lee Jin , Organ Nicole N
Published: August 2024

Pseudoaneurysm of the lateral perforating branch of the peroneal artery is exceedingly rare. To our knowledge, eight cases are described in the current literature, with five occurring as a result of trauma and the remainder being iatrogenic. We present a pseudoaneurysm of the lateral perforating peroneal artery in a professional athlete following an inversion–plantarflexion injury of the ankle. He described persistent pain and fluctuant swelling to the lateral aspect of the right ankle with sudden onset of increased pain and swelling 10 days after the initial injury. Arterial duplex identified a pseudoaneurysm of the right lateral perforating peroneal artery. Endovascular coil embolisation of the aneurysm resulted in almost immediate improvement in symptoms. The patient has since regained full function of the affected ankle. This case report highlights the necessity for clinicians to maintain a high index of suspicion in order to promptly investigate and appropriately manage this pathology.
Drug-induced psychosis following use of Ayahuasca: a presentation to forensic psychiatric services
Authors: Baker Morven Rosemary , O'Shea Christopher Iain
Published: August 2024

Ayahuasca is a plant-based psychoactive decoction, traditionally used by indigenous Amazonian peoples, which commonly contains the hallucinogen N,N-dimethyltryptamine (DMT). There is now growing interest across the Western world in psychedelics including Ayahuasca.

This case describes a previously well male with no risk factors for adverse psychiatric outcomes or forensic history. Following controlled Ayahuasca use, he developed an enduring psychotic episode, during which he significantly assaulted a relative and was admitted to a forensic psychiatric unit. He was treated with the antipsychotic aripiprazole, and his psychotic symptoms abated. 18 months following his admission, recovery has been sustained.

Previous case reports have described psychosis following Ayahuasca ingestion, but typically of short duration in patients with a personal or family history of psychiatric illness, or in those taking other substances. With the growing use of Ayahuasca, it is important to highlight that adverse effects may include more prolonged psychotic symptoms and the risk of psychotically mediated violence.
Late anastomotic perforation of the ileum 3 years after intestinal resection
Authors: Shrimanker Nikhita , Heller Nathan P , Souza Fabiola , Kim Daniel E
Published: August 2024

Late perforation of the ileum is a rare and potentially life-threatening complication following intestinal resection. We present a unique case of a woman in her 60s with a history of appendiceal carcinoid tumour, who underwent a right hemicolectomy. Positron emission tomography and surveillance CTs showed normal surgical changes and no recurrent malignancy. Three years postoperatively, she presented with severe abdominal pain. CT revealed a perforation along the ileal wall of the ileocolonic anastomosis. She underwent emergent resection and repeat ileocolonic anastomosis. We conclude that the patient had subclinical ischaemia of the anastomosis, which eventually progressed to perforation 3 years later. We discuss a literature review on late small intestinal anastomotic perforations and their associated risk factors. Our case and literature review emphasise the importance of considering delayed anastomotic leak in postoperative patients with a history of intestinal cancer, inflammatory bowel disease, Roux-en-Y enteroenterostomy or side-to-side anastomosis.
Glacially influenced provenance and Sturtian affinity revealed by detrital zircon U–Pb ages from sandstones in the Port Askaig Formation, Dalradian Supergroup
Authors: Rugen Elias J. , Pastore Guido , Vermeesch Pieter , Spencer Anthony M. , Webster David , Smith Adam G. G. , Carter Andrew , Shields Graham A.
Published: August 2024

The Cryogenian ‘Sturtian’ snowball Earth glaciation (
c.
717–658 Ma) likely had a major role in shaping continental landscapes and biotic radiations of the late Neoproterozoic Era. However, an incomplete sedimentary record and inadequate syn-glacial age constraints make Cryogenian studies challenging. We present detrital zircon U–Pb ages for >2000 zircons from 11 sandstone samples taken at <200 m stratigraphic resolution throughout the Port Askaig Formation, a
c.
1.1 km thick glaciogenic succession within the Dalradian Supergroup of Scotland and Ireland. Eight new maximum depositional age constraints, including a key constraint on deglaciation (<662.7 ± 7.8 Ma), support lithostratigraphic and stable isotope evidence that suggests the Port Askaig Formation preserves a relatively complete record of the global ‘Sturtian’ glaciation. An increasing contribution from Archean and Paleoproterozoic detritus to the sandstones through the lower
c.
500 m of the Port Askaig Formation likely reflects the progressive glacial unroofing of the previously buried Lewisian Gneiss terrane. Archean and Paleoproterozoic grains then become scarce in the uppermost
c.
300 m of the formation, which we attribute to glacial modification of the Laurentian continental margin landscape during the waning stage of ‘Sturtian’ glaciation. The disruption to sediment transport pathways caused by this modification, and evidenced by the detrital zircon data, points to partially warm-based ‘Sturtian’ ice sheets that were, to some degree, dynamic.
How to Protect of Reader Preference Privacy in Mobile Book Information Services: A Technical Method
Authors: Wu Zongda , Lin Guoqi , Liu Huawen , Xie Jian , Xu Guandong , Chen Enhong , Li Gang
Published: August 2024

Along with the wide popularization of mobile terminal devices such as smart phones, mobile libraries, which provide mobile book information services as the core business, have become an important part of people’s daily life. However, with the rapid development of emerging network technologies such as cloud computing, the server side of a mobile library has become more and more untrusted, and the problem of reader preference privacy associated with mobile book information services has become increasingly prominent. To this end, this paper proposes to construct a group of false requests of mobile book information service at a trusted client of a mobile library, which are then submitted to the untrusted server side together with a true request, so as to confuse the reader book preference privacy. Firstly, we define a theoretical model for the protection of reader preference privacy. It measures the confusion effect of false requests on a true request by introducing the concepts of book information entropy, location information entropy, and book location joint entropy. It measures the concealment effect of false requests on readers’ mobile book preferences by introducing the concepts of book category distance and location region distance. Secondly, we present a specific implementation algorithm of the theoretical model to generate a group of ideal false requests that meet the privacy constraints for readers’ true requests. Finally, theoretical analysis and experimental evaluation demonstrate the effectiveness of the proposed method, i.e., it can effectively improve the security of readers’ mobile book preference privacy on the untrusted server side, without compromising the availability of a mobile book information service.
Using Reinforcement Learning to Escape Automatic Filter-based Adversarial Example Defense
Authors: Li Yantao , Dan Kaijian , Lei Xinyu , Qin Huafeng , Deng Shaojiang , Zhou Gang
Published: August 2024

Deep neural networks can be easily fooled by the adversarial example, which is a specially crafted example with subtle and intentional perturbations. A plethora of papers have proposed to use filters to effectively defend against adversarial example attacks. However, we demonstrate that the automatic filter-based defenses may not be reliable. In this article, we present URL2AED, Using a Reinforcement Learning scheme TO escape the automatic filter-based Adversarial Example Defenses. Specifically, URL2AED uses a specially crafted policy gradient reinforcement learning (RL) algorithm to generate adversarial examples (AEs) that can escape automatic filter-based AE defenses. In particular, we properly design reward functions in policy-gradient RL for targeted attacks and non-targeted attacks, respectively. Furthermore, we customize training algorithms to reduce the possible action space in policy-gradient RL to accelerate URL2AED training while still ensuring that URL2AED generates successful AEs. To demonstrate the performance of the proposed URL2AED, we conduct extensive experiments on three public datasets in terms of different perturbation degrees of parameter, different filter parameters, transferability, and time consumption. The experimental results show that URL2AED achieves high attack success rates for automatic filter-based defenses and good cross-model transferability.
Effect of diabetes on microvascular morphology and permeability of rat skeletal muscle: in vivo imaging using two-photon laser scanning microscopy
Authors: Hotta Kazuki , Shimotsu Rie , Behnke Bradley J. , Masamoto Kazuto , Yagishita Kazuyoshi , Poole David C. , Kano Yutaka
Published: August 2024

Microvascular permeability in diabetic muscle was investigated using our original two-photon scanning laser microscopy method. Compared with controls, the leakage volume was increased in diabetic muscle, which was atrophic with smaller capillary diameter, endothelial cell thickening, and the appearance of more endothelial intercellular gaps or clefts, and large vesicles. Hyperpermeability was closely related to ultrafine structural changes of the capillary endothelial cell junctions.
Coadministration of PEGylated apohemoglobin and haptoglobin can limit vascular dysfunction in the microcirculation and prevent acute inflammation
Authors: Munoz Carlos J. , Lucas Daniela , Muller Cynthia R. , Martinez Jacinda , O’Boyle Quintin , Pires Ivan S. , Palmer Andre F. , Cabrales Pedro
Published: August 2024

Coadministration of PEGylated human apohemoglobin (PEG-apoHb)—a hemopexin (Hpx) mimetic that can scavenge free heme—and human plasma-derived haptoglobin (Hp) that can scavenge hemoglobin (Hb), reduces microcirculatory dysfunction and cardiac and kidney inflammation in a Hb-challenge model.
Figure S15 from Serine Depletion Promotes Antitumor Immunity by Activating Mitochondrial DNA-Mediated cGAS-STING Signaling
Authors: Saha Suchandrima , Ghosh Monisankar , Li Jinyu , Wen Asher , Galluzzi Lorenzo , Martinez Luis A. , Montrose David C.
Published: August 2024

Figure S15
Supplementary Equations from Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery
Authors: Zhang Shuming , Deshpande Atul , Verma Babita K. , Wang Hanwen , Mi Haoyang , Yuan Long , Ho Won Jin , Jaffee Elizabeth M. , Zhu Qingfeng , Anders Robert A. , Yarchoan Mark , Kagohara Luciane T. , Fertig Elana J. , Popel Aleksander S.
Published: August 2024

Supplemental mathematical equations of the spQSP model
Supplementary Fig. S9 from FBXO32 Stimulates Protein Synthesis to Drive Pancreatic Cancer Progression and Metastasis
Authors: Su Dan , Wang Ruobing , Chen Guangyu , Ding Chen , Liu Yueze , Tao Jinxin , Wang Yuanyang , Qiu Jiangdong , Luo Wenhao , Weng Guihu , Yang Gang , Zhang Taiping
Published: August 2024

Supplementary Fig. S9
Table 1 from Urinary Metabolite Diagnostic and Prognostic Liquid Biopsy Biomarkers of Lung Cancer in Nonsmokers and Tobacco Smokers
Authors: Dalal Bhavik , Tada Takeshi , Patel Daxesh P. , Pine Sharon R. , Khan Mohammed , Oike Takahiro , Kanke Yasuyuki , Parker Amelia L. , Haznadar Majda , Toulabi Leila , Krausz Kristopher W. , Robles Ana I. , Bowman Elise D. , Gonzalez Frank J. , Harris Curtis C.
Published: August 2024

Clinical characteristics of the study participants by smoking status.
Supplementary Table S6 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Authors: Song Yi , Boerner Thomas , Drill Esther , Shin Paul , Kumar Sandeep , Sigel Carlie , Cercek Andrea , Kemeny Nancy , Abou-Alfa Ghassan , Iacobuzio-Donahue Christine , Cowzer Darren , Schultz Nikolaus , Walch Henry , Balachandran Vinod , Groot Koerkamp Bas , Kingham Peter , Soares Kevin , Wei Alice , D’Angelica Michael , Drebin Jeffrey , Chandwani Rohit , Harding James J. , Jarnagin William
Published: August 2024

Incidence of the key genetic alterations observed in intrahepatic cholangiocarcinoma classified based on the biliary score.
Supplementary Figure S1 from A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Authors: Song Yi , Boerner Thomas , Drill Esther , Shin Paul , Kumar Sandeep , Sigel Carlie , Cercek Andrea , Kemeny Nancy , Abou-Alfa Ghassan , Iacobuzio-Donahue Christine , Cowzer Darren , Schultz Nikolaus , Walch Henry , Balachandran Vinod , Groot Koerkamp Bas , Kingham Peter , Soares Kevin , Wei Alice , D’Angelica Michael , Drebin Jeffrey , Chandwani Rohit , Harding James J. , Jarnagin William
Published: August 2024

Supplementary Figure S1 One-versus-rest precision-recall area under the curve (AUC) of each class and the overall accuracy of the three-class model (A) and the two-class model (B). EHC: extrahepatic cholangiocarcinoma; GBC: gallbladder cancer; HCC: hepatocellular carcinoma.
Figure 4 from Urinary Metabolite Diagnostic and Prognostic Liquid Biopsy Biomarkers of Lung Cancer in Nonsmokers and Tobacco Smokers
Authors: Dalal Bhavik , Tada Takeshi , Patel Daxesh P. , Pine Sharon R. , Khan Mohammed , Oike Takahiro , Kanke Yasuyuki , Parker Amelia L. , Haznadar Majda , Toulabi Leila , Krausz Kristopher W. , Robles Ana I. , Bowman Elise D. , Gonzalez Frank J. , Harris Curtis C.
Published: August 2024

ROC curves represent the accuracy of metabolite CR, NANA, and the combination with AUC for smoking status in both cohorts: (A) nonsmokers and (B) smokers. PC, population controls.
Supplementary Table S1 from Intraperitoneal Nivolumab after Debulking Surgery and Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer: A Phase I Study with Expansion Cohort
Authors: Corbaux Pauline , Freyer Gilles , Glehen Olivier , You Benoît , Bakrin Naoual , Gelot Audrey , Dayde David , Sajous Christophe , Piffoux Max , Péron Julien , Lescuyer Gaelle , Payen Lea , Kepenekian Vahan
Published: August 2024

Representativeness of study participants
Supplementary Data S1 from Intraperitoneal Nivolumab after Debulking Surgery and Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer: A Phase I Study with Expansion Cohort
Authors: Corbaux Pauline , Freyer Gilles , Glehen Olivier , You Benoît , Bakrin Naoual , Gelot Audrey , Dayde David , Sajous Christophe , Piffoux Max , Péron Julien , Lescuyer Gaelle , Payen Lea , Kepenekian Vahan
Published: August 2024

Comprehensive protocol of the study
Supplementary Table S1 from Tissue-Free Liquid Biopsies Combining Genomic and Methylation Signals for Minimal Residual Disease Detection in Patients with Early Colorectal Cancer from the UK TRACC Part B Study
Authors: Slater Susanna , Bryant Annette , Aresu Maria , Begum Ruwaida , Chen Hsiang-Chi , Peckitt Clare , Lazaro-Alcausi Retchel , Carter Paul , Anandappa Gayathri , Khakoo Shelize , Melcher Lucinda , Potter Vanessa , Marti Francisca M. , Huang Joesph , Branagan Graham , George Nicol , Abulafi Muti , Duff Sarah , Raja Ashraf , Gupta Ashish , West Nicholas , Bucheit Leslie , Rich Thereasa , Chau Ian , Cunningham David , Starling Naureen
Published: August 2024

Comparison of TRACC Part B cohort with prevalence of CRC in the general population
Supplementary Figure S4 from Tissue-Free Liquid Biopsies Combining Genomic and Methylation Signals for Minimal Residual Disease Detection in Patients with Early Colorectal Cancer from the UK TRACC Part B Study
Authors: Slater Susanna , Bryant Annette , Aresu Maria , Begum Ruwaida , Chen Hsiang-Chi , Peckitt Clare , Lazaro-Alcausi Retchel , Carter Paul , Anandappa Gayathri , Khakoo Shelize , Melcher Lucinda , Potter Vanessa , Marti Francisca M. , Huang Joesph , Branagan Graham , George Nicol , Abulafi Muti , Duff Sarah , Raja Ashraf , Gupta Ashish , West Nicholas , Bucheit Leslie , Rich Thereasa , Chau Ian , Cunningham David , Starling Naureen
Published: August 2024

Venn diagrams of ctDNA detection by call method according to analysis population
Supplementary Table S9 from Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Authors: Saner Flurina A.M. , Takahashi Kazuaki , Budden Timothy , Pandey Ahwan , Ariyaratne Dinuka , Zwimpfer Tibor A. , Meagher Nicola S. , Fereday Sian , Twomey Laura , Pishas Kathleen I. , Hoang Therese , Bolithon Adelyn , Traficante Nadia , Alsop Kathryn , Christie Elizabeth L. , Kang Eun-Young , Nelson Gregg S. , Ghatage Prafull , Lee Cheng-Han , Riggan Marjorie J. , Alsop Jennifer , Beckmann Matthias W. , Boros Jessica , Brand Alison H. , Brooks-Wilson Angela , Carney Michael E. , Coulson Penny , Courtney-Brooks Madeleine , Cushing-Haugen Kara L. , Cybulski Cezary , El-Bahrawy Mona A. , Elishaev Esther , Erber Ramona , Gayther Simon A. , Gentry-Maharaj Aleksandra , Gilks C. Blake , Harnett Paul R. , Harris Holly R. , Hartmann Arndt , Hein Alexander , Hendley Joy , Hernandez Brenda Y. , Jakubowska Anna , Jimenez-Linan Mercedes , Jones Michael E. , Kaufmann Scott H. , Kennedy Catherine J. , Kluz Tomasz , Koziak Jennifer M. , Kristjansdottir Björg , Le Nhu D. , Lener Marcin , Lester Jenny , Lubiński Jan , Mateoiu Constantina , Orsulic Sandra , Ruebner Matthias , Schoemaker Minouk J. , Shah Mitul , Sharma Raghwa , Sherman Mark E. , Shvetsov Yurii B. , Soong T. Rinda , Steed Helen , Sukumvanich Paniti , Talhouk Aline , Taylor Sarah E. , Vierkant Robert A. , Wang Chen , Widschwendter Martin , Wilkens Lynne R. , Winham Stacey J. , Anglesio Michael S. , Berchuck Andrew , Brenton James D. , Campbell Ian , Cook Linda S. , Doherty Jennifer A. , Fasching Peter A. , Fortner Renée T. , Goodman Marc T. , Gronwald Jacek , Huntsman David G. , Karlan Beth Y. , Kelemen Linda E. , Menon Usha , Modugno Francesmary , Pharoah Paul D.P. , Schildkraut Joellen M. , Sundfeldt Karin , Swerdlow Anthony J. , Goode Ellen L. , DeFazio Anna , Köbel Martin , Ramus Susan J. , Bowtell David D.L. , Garsed Dale W.
Published: August 2024

Supplementary Table S9. Primers used in this study.
Supplementary Table S8 from Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Authors: Saner Flurina A.M. , Takahashi Kazuaki , Budden Timothy , Pandey Ahwan , Ariyaratne Dinuka , Zwimpfer Tibor A. , Meagher Nicola S. , Fereday Sian , Twomey Laura , Pishas Kathleen I. , Hoang Therese , Bolithon Adelyn , Traficante Nadia , Alsop Kathryn , Christie Elizabeth L. , Kang Eun-Young , Nelson Gregg S. , Ghatage Prafull , Lee Cheng-Han , Riggan Marjorie J. , Alsop Jennifer , Beckmann Matthias W. , Boros Jessica , Brand Alison H. , Brooks-Wilson Angela , Carney Michael E. , Coulson Penny , Courtney-Brooks Madeleine , Cushing-Haugen Kara L. , Cybulski Cezary , El-Bahrawy Mona A. , Elishaev Esther , Erber Ramona , Gayther Simon A. , Gentry-Maharaj Aleksandra , Gilks C. Blake , Harnett Paul R. , Harris Holly R. , Hartmann Arndt , Hein Alexander , Hendley Joy , Hernandez Brenda Y. , Jakubowska Anna , Jimenez-Linan Mercedes , Jones Michael E. , Kaufmann Scott H. , Kennedy Catherine J. , Kluz Tomasz , Koziak Jennifer M. , Kristjansdottir Björg , Le Nhu D. , Lener Marcin , Lester Jenny , Lubiński Jan , Mateoiu Constantina , Orsulic Sandra , Ruebner Matthias , Schoemaker Minouk J. , Shah Mitul , Sharma Raghwa , Sherman Mark E. , Shvetsov Yurii B. , Soong T. Rinda , Steed Helen , Sukumvanich Paniti , Talhouk Aline , Taylor Sarah E. , Vierkant Robert A. , Wang Chen , Widschwendter Martin , Wilkens Lynne R. , Winham Stacey J. , Anglesio Michael S. , Berchuck Andrew , Brenton James D. , Campbell Ian , Cook Linda S. , Doherty Jennifer A. , Fasching Peter A. , Fortner Renée T. , Goodman Marc T. , Gronwald Jacek , Huntsman David G. , Karlan Beth Y. , Kelemen Linda E. , Menon Usha , Modugno Francesmary , Pharoah Paul D.P. , Schildkraut Joellen M. , Sundfeldt Karin , Swerdlow Anthony J. , Goode Ellen L. , DeFazio Anna , Köbel Martin , Ramus Susan J. , Bowtell David D.L. , Garsed Dale W.
Published: August 2024

Supplementary Table S8. Antibodies and reagents.
Supplementary Figure S1 from Tissue-Free Liquid Biopsies Combining Genomic and Methylation Signals for Minimal Residual Disease Detection in Patients with Early Colorectal Cancer from the UK TRACC Part B Study
Authors: Slater Susanna , Bryant Annette , Aresu Maria , Begum Ruwaida , Chen Hsiang-Chi , Peckitt Clare , Lazaro-Alcausi Retchel , Carter Paul , Anandappa Gayathri , Khakoo Shelize , Melcher Lucinda , Potter Vanessa , Marti Francisca M. , Huang Joesph , Branagan Graham , George Nicol , Abulafi Muti , Duff Sarah , Raja Ashraf , Gupta Ashish , West Nicholas , Bucheit Leslie , Rich Thereasa , Chau Ian , Cunningham David , Starling Naureen
Published: August 2024

ctDNA detection rate at baseline and postoperative timepoints according to stage in the primary analysis population (n=143)
Supplementary Table S17 from Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Authors: Saner Flurina A.M. , Takahashi Kazuaki , Budden Timothy , Pandey Ahwan , Ariyaratne Dinuka , Zwimpfer Tibor A. , Meagher Nicola S. , Fereday Sian , Twomey Laura , Pishas Kathleen I. , Hoang Therese , Bolithon Adelyn , Traficante Nadia , Alsop Kathryn , Christie Elizabeth L. , Kang Eun-Young , Nelson Gregg S. , Ghatage Prafull , Lee Cheng-Han , Riggan Marjorie J. , Alsop Jennifer , Beckmann Matthias W. , Boros Jessica , Brand Alison H. , Brooks-Wilson Angela , Carney Michael E. , Coulson Penny , Courtney-Brooks Madeleine , Cushing-Haugen Kara L. , Cybulski Cezary , El-Bahrawy Mona A. , Elishaev Esther , Erber Ramona , Gayther Simon A. , Gentry-Maharaj Aleksandra , Gilks C. Blake , Harnett Paul R. , Harris Holly R. , Hartmann Arndt , Hein Alexander , Hendley Joy , Hernandez Brenda Y. , Jakubowska Anna , Jimenez-Linan Mercedes , Jones Michael E. , Kaufmann Scott H. , Kennedy Catherine J. , Kluz Tomasz , Koziak Jennifer M. , Kristjansdottir Björg , Le Nhu D. , Lener Marcin , Lester Jenny , Lubiński Jan , Mateoiu Constantina , Orsulic Sandra , Ruebner Matthias , Schoemaker Minouk J. , Shah Mitul , Sharma Raghwa , Sherman Mark E. , Shvetsov Yurii B. , Soong T. Rinda , Steed Helen , Sukumvanich Paniti , Talhouk Aline , Taylor Sarah E. , Vierkant Robert A. , Wang Chen , Widschwendter Martin , Wilkens Lynne R. , Winham Stacey J. , Anglesio Michael S. , Berchuck Andrew , Brenton James D. , Campbell Ian , Cook Linda S. , Doherty Jennifer A. , Fasching Peter A. , Fortner Renée T. , Goodman Marc T. , Gronwald Jacek , Huntsman David G. , Karlan Beth Y. , Kelemen Linda E. , Menon Usha , Modugno Francesmary , Pharoah Paul D.P. , Schildkraut Joellen M. , Sundfeldt Karin , Swerdlow Anthony J. , Goode Ellen L. , DeFazio Anna , Köbel Martin , Ramus Susan J. , Bowtell David D.L. , Garsed Dale W.
Published: August 2024

Supplementary Table S17. Half maximum inhibitory concentrations (IC50) for cisplatin (72 hours), paclitaxel (72 hours), or olaparib (120 hours) in HGSC cell lines with innate RB1 and/or BRCA1 alterations.
Supplementary Figure S6 from Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Authors: Saner Flurina A.M. , Takahashi Kazuaki , Budden Timothy , Pandey Ahwan , Ariyaratne Dinuka , Zwimpfer Tibor A. , Meagher Nicola S. , Fereday Sian , Twomey Laura , Pishas Kathleen I. , Hoang Therese , Bolithon Adelyn , Traficante Nadia , Alsop Kathryn , Christie Elizabeth L. , Kang Eun-Young , Nelson Gregg S. , Ghatage Prafull , Lee Cheng-Han , Riggan Marjorie J. , Alsop Jennifer , Beckmann Matthias W. , Boros Jessica , Brand Alison H. , Brooks-Wilson Angela , Carney Michael E. , Coulson Penny , Courtney-Brooks Madeleine , Cushing-Haugen Kara L. , Cybulski Cezary , El-Bahrawy Mona A. , Elishaev Esther , Erber Ramona , Gayther Simon A. , Gentry-Maharaj Aleksandra , Gilks C. Blake , Harnett Paul R. , Harris Holly R. , Hartmann Arndt , Hein Alexander , Hendley Joy , Hernandez Brenda Y. , Jakubowska Anna , Jimenez-Linan Mercedes , Jones Michael E. , Kaufmann Scott H. , Kennedy Catherine J. , Kluz Tomasz , Koziak Jennifer M. , Kristjansdottir Björg , Le Nhu D. , Lener Marcin , Lester Jenny , Lubiński Jan , Mateoiu Constantina , Orsulic Sandra , Ruebner Matthias , Schoemaker Minouk J. , Shah Mitul , Sharma Raghwa , Sherman Mark E. , Shvetsov Yurii B. , Soong T. Rinda , Steed Helen , Sukumvanich Paniti , Talhouk Aline , Taylor Sarah E. , Vierkant Robert A. , Wang Chen , Widschwendter Martin , Wilkens Lynne R. , Winham Stacey J. , Anglesio Michael S. , Berchuck Andrew , Brenton James D. , Campbell Ian , Cook Linda S. , Doherty Jennifer A. , Fasching Peter A. , Fortner Renée T. , Goodman Marc T. , Gronwald Jacek , Huntsman David G. , Karlan Beth Y. , Kelemen Linda E. , Menon Usha , Modugno Francesmary , Pharoah Paul D.P. , Schildkraut Joellen M. , Sundfeldt Karin , Swerdlow Anthony J. , Goode Ellen L. , DeFazio Anna , Köbel Martin , Ramus Susan J. , Bowtell David D.L. , Garsed Dale W.
Published: August 2024

Supplementary Figure S6. Mutational signatures in homologous recombination deficiency and RB1 subgroups.