bluuebunny/crossref_metadata_2025 huggingface dataset:
Usefulness of direct intratumoral administration of doxorubicin hydrochloride with an electro-osmosis–assisted pump
Authors: Ito Ayu , Itakura Shoko , Hasegawa Yuya , Hashimoto Miyu , Okada Akie , Hirafuji Mamoru , Nakamura Hidenori , Sugibayashi Kenji , Todo Hiroaki
Published: April 2023

Patients receiving chemotherapy by intravenous (i.v.) or oral administration of anticancer drugs often experience side effects. In this study, an electro-osmotic flow (EO) pump was used for the direct administration of an anticancer drug with minimum side effects. Doxorubicin hydrochloride (DXR) was used as an anticancer drug, and its antitumor effect and toxicity were evaluated in comparison with i.v. administration. Balb/c female mice were subcutaneously transplanted with a breast cancer cell line (4T1/Luc) stably expressing luciferase, and 20 μL of DXR solution (1.0 mg/mL) was administered intratumorally (i.t.) at a slow rate (0.6 µL/min) using an EO pump or rapidly using a syringe. For comparison, 100 μL of DXR solution was injected through the tail vein at the same dose and a 5-times higher dose. A tumor growth inhibitory effect without significant weight loss was observed with direct i.t. administration of DXR using an EO pump. On the other hand, no suppressive tumor growth effect was observed with i.v. administration of DXR at the same dose. Although there was no significant difference in the suppression effect on tumor growth between i.t. administration with EO pump and syringe, the peripheral skin concentration of DXR were decreased after slow administration with EO pump compared with that after rapidly administration with a syringe. These results indicated that direct i.t. administration of DXR with lower dosing using an EO pump at slower administration rate may be useful for exhibiting antitumor effects and suppressing systemic side effects. In addition, the blood concentration and the peripheral skin concentration of DXR after administration at lower rate with EO pump were decreased compared with those after the rapidly administration with a syringe.
Global research on submarine landslides, 2001–2020
Authors: Chen Wenwen , Xing Junhui
Published: April 2023

Submarine landslides, one of the hotspots in marine geoscience research, are one of the most harmful marine geological disasters. To understand the research status and further research directions of submarine landslides, this paper analyzed the global submarine landslide-related work during the period from 2001 to 2020. To achieve this objective, Science Citation Index Expand and the Social Sciences Citation Index, belonging to the WoS Core Collection, were the two bibliographic databases selected as a reference. In this study, we focused on document types, publishing languages, subject categories, journals’ productivity, countries and author, and co-occurrence keywords network. Geoscience multidisciplinary, Geochemistry Geophysics, Oceanography, Environmental Sciences, and Materials Science Multidisciplinary have been the most commonly used science categories in the past two decades. Marine Geology, Marine and Petroleum Geology, Journal of Volcanology, and Geothermal Research are the three most productive journals on submarine landslides. Marine Geology is the most active journal among all the journals. The United States, the United Kingdom, China, Germany, and France are the five most productive countries. At the institutional level, the Centre National De la Recherche Scientifique (France) is the most active institution, followed by the Chinese Academy of Sciences (China) and Helmholtz Association (Germany). Masson DG and Talling PJ from the United Kingdom contribute to the most high-quality submarine landslide-related publications. Analyzing by CiteSpace, the five largest clusters in the submarine landslide field are “gas hydrate,” “turbidity current,” “thin film,” “debris avalanche,” and “submarine canyon.” Active further research directions of submarine landslides are “south china sea,” “slump,” and “submarine mass failure.”
Temporal and spatial change of habitat quality and its driving forces: The case of Tacheng region, China
Authors: Ge Yisong , Li Chengzhi , Zhang Tai , Wang Bin
Published: April 2023

Habitat quality assessment is an important basis for ecological restoration practice. Taking the Tacheng region as an example, the InVEST model was used to evaluate the habitat quality of the Tacheng region in five periods from 2000 to 2020, and analyze the reasons for its changes, to provide theoretical guidance for ecological restoration practice in arid areas. The conclusions were that from 2000 to 2020, the habitat quality in the Tacheng region improved slightly, and the value of the habitat index in the Tacheng region was the highest in 2010, which was 0.577, and then decreased slightly. The habitat quality in the Tacheng region was significantly influenced by land use type conversion and precipitation. The change in land use type directly affected the change in habitat quality. The study region is located in an arid area; the forest land and grassland native to the region have more vegetation communities and genera of species and can be self-sustaining and resilient to disturbance, having high scores for habitat quality. The species of arable land is a monoculture; it cannot be self-sustaining and resilient to disturbance, and though it has high vegetation cover, the value of habitat quality is lower than that of forestland and grassland. The vegetation of unused land is rare, and the ecosystem of unused land is sensitive and vulnerable; the habitat quality scores are very low. The conversion of forest land, grassland, arable land, and unused land would directly affect the value of habitat quality, and conversion was the main factor affecting the change in habitat quality. In addition, precipitation was also an important factor affecting the change in habitat quality in the Tacheng region, which affected the biomass of natural vegetation and then affected the habitat quality. The results provided the temporal and spatial change of habitat quality and its driving forces in the Tacheng region, which helps determine appropriate measures and sites in ecological restoration projects.
Development of anti-foulant ultraviolet-assisted polyvinyl alcohol layer on the polysulfone-based nanohybrid membrane for industrial rubber wastewater decontamination
Authors: Kusworo Tutuk Djoko , Kumoro Andri Cahyo , Aryanti Nita , Lingga Fadhilah Fatma , Widiastuti Ade , Vetcher Alexandre A. , Dalanta Febio
Published: April 2023

Introduction: Membrane fouling has been reported to be one of the bottlenecks of membrane technologies for wastewater treatment. To mitigate its negative impacts, we fabricated polysulfone membrane (PSf) composites made of silica (SiO2) and graphene oxide (GO) nanoparticles that modified with ultraviolet (UV)-assisted polyvinyl alcohol layer on the membrane surface.

Methods: The membrane composite was synthesized using non-solvent induced phase separation (NIPS) method. The membrane was further treated by UV irradiation and cross-linked with PVA coating to cope with the fouling problem. The modified membrane was applied for industrial rubber wastewater decontamination.

Results: The UV irradiation and cross-linked PVA coating to the PSf/GO-SiO2 membrane improved the pseudo-steady state permeate flux by 60.15% from 20.05 to 50.32 L/m2hr and maintained the permeate flux up to 82.33%. About 85% of total dissolved solids (TDS), 81% of chemical oxygen demand (COD), and 84% of ammonia compound (NH3) with initial concentrations of 335.76, 242.55, 175.19 mg/L, respectively, could be removed after 8 h of membrane treatment. The modified membrane also exhibited an excellent flux recovery ratio of up to 83%.

Discussion: The modified membrane changed the fouling mechanism from pore blockage to cake filtration, which signifies the capability of the membrane to tackle severe fouling tendency. The cross-linked UV/PVA coating reduced fouling formation by reducing the adsorptive interactions between the foulant molecules and the membrane surface by enhancing membrane surface hydrophilicity. This implies that incorporating GO/SiO2 nanoparticles with UV irradiation and PVA coating substantially enhanced the physicochemical properties of the PSf membrane.
Integrated ecosystem assessment around islands of the tropical South Mid-Atlantic Ridge
Authors: Rodrigues Amanda R. , Floeter Sergio R. , Gomes Vicente , Ferrari Débora S. , Giglio Vinicius J. , Silva Fernanda C. , Liedke Ana M. R. , Ferreira Carlos E. L. , Howell Kerry , Gasalla Maria A.
Published: April 2023

The South Mid Atlantic Ridge comprises three main oceanic islands in the equatorial and tropical portions of the Atlantic Ocean. These islands are isolated from each other and equidistant from both the continental margins of South America and Africa, sharing common patterns but with different types of human use and pressures. Moreover, the areas beyond national jurisdiction between those islands are visited and exploited by distant fishing fleets and include large areas of shipping activity for commodities. Here, a pioneering integrated ecosystem assessment (IEA) process is constructed for the region among Saint Peter and Saint Paul’s Archipelago (Brazil), Saint Helena Island and Ascension Island (UK overseas territories). For that, we used a qualitative assessment of risks arising from anthropogenic activities, representing a novel contribution to the field. The Options for Delivering Ecosystem-Based Marine Management (ODEMM) approach was applied to trace sector–pressure–component pathways. A ‘linkage framework’ was outlined including pressures affecting each ecosystem component, and supported a process of knowledge attributions that scored the impact risks. All results were validated with regional stakeholders through workshops, including local and international management bodies, non-governmental organizations (NGOs) and scientists. The approach focused on a significant area among encompassing the open ocean, shallow and deep-sea biomes, analyzing the main sectors and pressures affecting the ecological components. Our results identified 14 sectors and 16 key pressures associated with 23 ecosystem components, totaling 780 impact chains. Fishing, shipping, wastewater, and tourism/recreation appeared as the top impacting sectors. Fishing and shipping were the most connected with ecosystem components links. Litter, species extraction, contaminants, and bycatch were the pressures that had the highest risk of impact values. Lastly, demersal and pelagic fish and pelagic and demersal elasmobranchs were the groups with the highest risk related to overall impacts, which were supported by local and regional evidence from long term monitoring programs and local studies. Our study demonstrated that these seemingly pristine islands and oceanic waters are already experiencing human impacts that should be addressed by local both conservation measures and international agreements. We also highlight the pressures that should be prioritized for better monitoring and policy, as well as those linkage components that have been less investigated.
Response of coccolithophore communities to oceanographic and atmospheric processes across the North- and Equatorial Atlantic
Authors: Guerreiro Catarina V. , Ferreira Afonso , Cros Lluisa , Stuut Jan-Berend , Baker Alex , Tracana Andreia , Pinto Catarina , Veloso Vera , Rees Andrew P. , Cachão Mário A. P. , Nunes Telmo , Brotas Vanda
Published: April 2023

Changes in coccolithophore productivity in response to climate-driven ocean warming are likely to have cascading biogeochemical effects that feed back to the changing climate. This paper investigates the role (and interplay) of large-scale oceanographic and atmospheric processes across the North- and Equatorial Atlantic, including Saharan dust deposition, on the distribution of coccolithophore communities. The study is based on biological and hydrological data collected across the photic zone of the ocean, and aerosol data collected from the lower atmosphere, across 50°N–1°S during the Atlantic Meridional Transect in boreal Autumn of 2018 (AMT28), in synergy with Earth Observations. Results confirm existing understanding of the distribution of coccolithophore communities which are related to major meridional hydrological gradients across the North Atlantic. Dynamic, oxygenated and microphytoplankton-enriched waters at higher-latitudes were characterized by less diverse coccolithophore populations, dominated by placolith-bearing r-selected coccolithophores. In contrast, the heavily stratified and picoplankton-enriched waters of the subtropical gyre revealed more diverse populations, dominated by umbelliform coccolithophores and holococcolithophores at the surface, and by floriform taxa in the lower photic zone. Mean concentrations of 14.4×103cells/L present in the North Atlantic Tropical Gyre Province (30–12°N), only slightly lower compared to 17.7×103cells/L produced in the North Atlantic Drift province (50–40°N), provide a snapshot perspective on the importance of coccolithophore production in heavily stratified gyre conditions. Higher concentrations of 19’-Hexanoyloxyfucoxanthin (HexFuco) in regions of enhanced production of r-selected placolith-bearing species suggest that this pigment should not be generalized as a proxy for the entire coccolithophore community. Enhanced abundances of fast-bloomingEmiliania huxleyiandGephyrocapsa oceanica, and of cyanobacteria (including both picoplankton and N2-fixingTrichodesmiumspp.) at the surface of the region of more persistent Saharan dust deposition (at ~12-10°N) appeared to result from dust-born nutrient input. Underneath this stratified surface layer, enhanced productivity in the deep chlorophyll maximum (DCM) appeared decoupled from that on the surface, fueled by geostrophic eastward shoaling of the nutricline across the tropical North Atlantic. As this was the region of highest macronutrient concentrations measured along and below the nutricline, our data suggest that the NE tropical Atlantic may act as a permanent dust-born nutrient depocenter as previously hypothesized.
Concern about the human health implications of marine biodiversity loss is higher among less educated and poorer citizens: Results from a 14-country study in Europe
Authors: Davison Sophie M. C. , White Mathew P. , Pahl Sabine , Taylor Tim , Borja Angel , McMeel Oonagh , Kellett Paula , Roberts Bethany R. , Fleming Lora E.
Published: April 2023

Introduction

Marine biodiversity loss has direct and indirect effects on human health and wellbeing. Recent European data suggest that the public is aware of this, identifying marine biodiversity protection as its top research priority in terms of oceans and human health, rated higher than issues such as plastic, chemical, and microbial pollution.

Methods

The current study aimed to better understand key sociodemographic and personality predictors of concern about marine biodiversity loss and the desire for more research into marine biodiversity protection, in an attempt to support communication efforts targeting specific sectors in society. Data were drawn from nationally representative samples of 14 European countries (n = 14,167).

Results

Results show greater concern about marine biodiversity loss and support for more research into marine biodiversity protection by older adults, females, and individuals: (i) without (vs. with) a university degree; (ii) with lower (vs. middle) incomes; (iii) who identified as politically left-wing; (iv) who visited the coast more often; and (v) those with more open, agreeable and conscientious personalities.

Discussion

These results suggest that, although concern and research support are generally high among European citizens, policy makers and communicators need to take into consideration individual-level variation.
Effects of awake prone position vs. usual care on acute hypoxemic respiratory failure in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials
Authors: Peng Qing , Yang Sheng , Zhang Yu , Zhao Wenjie , Hu Man , Meng Bo , Ni Huanhuan , Min Lingfeng , Yu Jiangquan , Wang Yongxiang , Zhang Liang
Published: April 2023

Background

Previous studies have shown that an awake prone position may be beneficial for the treatment of acute respiratory distress syndrome (ARDS) or acute hypoxic respiratory failure (AHRF) in patients with COVID-19, but the results are not consistent, especially in terms of oxygenation outcomes and intubation rate. This systematic review and meta-analysis assessed the effects of the awake prone position on AHRF in patients with COVID-19 with all randomized controlled trials (RCTs).

Methods

An extensive search of online databases, including MEDLINE, Embase, Web of Science, and Cochrane Central Register of Controlled Trials from 1 December 2019 to 30 October 2022, with no language restrictions was performed. This systematic review and meta-analysis are based on the PRISMA statement. We only included RCTs and used the Cochrane risk assessment tool for quality assessment.

Results

Fourteen RCTs fulfilled the selection criteria, and 3,290 patients were included. A meta-analysis found that patients in the awake prone position group had more significant improvement in the SpO2/FiO2 ratio [mean difference (MD): 29.76; 95% confidence interval (CI): 1.39–48.13; P = 0.001] compared with the usual care. The prone position also reduced the need for intubation [odd ratio (OR): 0.72; 95% CI: 0.61 to 0.84; P < 0.0001; I2 = 0%]. There was no significant difference in mortality, hospital length of stay, incidence of intensive care unit (ICU) admission, and adverse events between the two groups.

Conclusion

The awake prone position was a promising intervention method, which is beneficial to improve the oxygenation of patients with ARDS or AHRF caused by COVID-19 and reduce the need for intubation. However, the awake prone position showed no obvious advantage in mortality, hospital length of stay, incidence of ICU admission, and adverse events.

Systematic review registration

International Prospective Register of Systematic Reviews (PROSPERO), identifier: CRD42022367885.
Meta-analysis of the association between dietary inflammatory index and cognitive health
Authors: Ding Tianze , Aimaiti Maimaitiyusupu , Cui Shishuang , Shen Junhao , Lu Mengjie , Wang Lei , Bian Dongsheng
Published: April 2023

Background

Some studies have shown that a pro-inflammatory diet may be associated with cognitive function, but their conclusions have varied considerably. We here present a meta-analysis of the current published literature on DII score and its association with cognitive health.

Methods

In this meta-analysis, the PubMed, Embase, Web of Science, and Cochrane databases were searched in September 2022. The reported indexes, specifically OR, RR, and β, were extracted and analyzed using R version 3.1.0.

Results

A total of 636 studies in databases were identified, and 12 were included in the meta-analysis. Higher DII was associated with an increased risk of AD and MCI (OR = 1.34; 95% CI = 1.21–1.49). Meanwhile, it may also cause global function impairment (categorical: OR = 1.63; 95% CI = 1.36–1.96) and verbal fluency impairment (continuous: OR = 0.18; 95% IC = 0.08–0.42). But there was no significant association between DII and executive function (categorical: OR = 1.12; 95% IC = 0.84–1.49; continuous: OR = 0.48; 95% IC = 0.19–1.21) or episodic memory (continuous: OR = 0.56; 95% IC = 0.30–1.03).

Conclusion

A pro-inflammatory diet is related to AD, MCI, and the functions of some cognitive domains (specifically global function and verbal fluency). However, the current evidence on the role of diet-induced inflammation in different cognitive domains should be supported by further studies in the future.
Predictive power of deep-learning segmentation based prognostication model in non-small cell lung cancer
Authors: Gainey Jordan C. , He Yusen , Zhu Robert , Baek Stephen S. , Wu Xiaodong , Buatti John M. , Allen Bryan G. , Smith Brian J. , Kim Yusung
Published: April 2023

Purpose

The study aims to create a model to predict survival outcomes for non-small cell lung cancer (NSCLC) after treatment with stereotactic body radiotherapy (SBRT) using deep-learning segmentation based prognostication (DESEP).

Methods

The DESEP model was trained using imaging from 108 patients with NSCLC with various clinical stages and treatment histories. The model generated predictions based on unsupervised features learned by a deep-segmentation network from computed tomography imaging to categorize patients into high and low risk groups for overall survival (DESEP-predicted-OS), disease specific survival (DESEP-predicted-DSS), and local progression free survival (DESEP-predicted-LPFS). Serial assessments were also performed using auto-segmentation based volumetric RECISTv1.1 and computer-based unidimensional RECISTv1.1 patients was performed.

Results

There was a concordance between the DESEP-predicted-LPFS risk category and manually calculated RECISTv1.1 (φ=0.544, p=0.001). Neither the auto-segmentation based volumetric RECISTv1.1 nor the computer-based unidimensional RECISTv1.1 correlated with manual RECISTv1.1 (p=0.081 and p=0.144, respectively). While manual RECISTv1.1 correlated with LPFS (HR=6.97,3.51-13.85, c=0.70, p<0.001), it could not provide insight regarding DSS (p=0.942) or OS (p=0.662). In contrast, the DESEP-predicted methods were predictive of LPFS (HR=3.58, 1.66-7.18, c=0.60, p<0.001), OS (HR=6.31, 3.65-10.93, c=0.71, p<0.001) and DSS (HR=9.25, 4.50-19.02, c=0.69, p<0.001). The promising results of the DESEP model were reproduced for the independent, external datasets of Stanford University, classifying survival and ‘dead’ group in their Kaplan-Meyer curves (p = 0.019).

Conclusion

Deep-learning segmentation based prognostication can predict LPFS as well as OS, and DSS after SBRT for NSCLC. It can be used in conjunction with current standard of care, manual RECISTv1.1 to provide additional insights regarding DSS and OS in NSCLC patients receiving SBRT.

While current standard of care, manual RECISTv1.1 correlated with local progression free survival (LPFS) (HR=6.97,3.51-13.85, c=0.70, p<0.001), it could not provide insight regarding disease specific survival (DSS) (p=0.942) or overall survival (OS) (p=0.662). In contrast, the deep-learning segmentation based prognostication (DESEP)-predicted methods were predictive of LPFS (HR=3.58, 1.66-7.18, c=0.60, p<0.001), OS (HR=6.31, 3.65-10.93, c=0.71, p<0.001) and DSS (HR=9.25, 4.50-19.02, c=0.69, p<0.001). DESEP can be used in conjunction with current standard of care, manual RECISTv1.1 to provide additional insights regarding DSS and OS in NSCLC patients.
State-of-the-art review and update of in vivo models of necrotizing enterocolitis
Authors: Bautista Geoanna M. , Cera Anjali J. , Chaaban Hala , McElroy Steven J.
Published: April 2023

NEC remains one of the most common causes of mortality and morbidity in preterm infants. Animal models of necrotizing enterocolitis (NEC) have been crucial in improving our understanding of this devastating disease and identifying biochemical pathways with therapeutic potential. The pathogenesis of NEC remains incompletely understood, with no specific entity that unifies all infants that develop NEC. Therefore, investigators rely on animal models to manipulate variables and provide a means to test interventions, making them valuable tools to enhance our understanding and prevent and treat NEC. The advancements in molecular analytic tools, genetic manipulation, and imaging modalities and the emergence of scientific collaborations have given rise to unique perspectives and disease correlates, creating novel pathways of investigation. A critical review and understanding of the current phenotypic considerations of the highly relevant animal models of NEC are crucial to developing novel therapeutic and preventative strategies for NEC.
Normalized difference vegetation index sensor-based nitrogen management in bread wheat (Triticum aestivum L.): Nutrient uptake, use efficiency, and partial nutrient balance
Authors: Mitra Biplab , Singha Prantick , Roy Chowdhury Arnab , Sinha Abhas Kumar , Skalicky Milan , Brestic Marian , Alamri Saud , Hossain Akbar
Published: April 2023

The present experiment was conducted to assess the impact of fixed and variable doses (using a normalized difference vegetation index-sensor) of nitrogen (N) on wheat yields, nutrient uptake, nitrogen use efficiency, and soil nitrogen balance through the optimization of nitrogen dose. There were 10 treatments based on fixed and variable doses with different splits, and each treatment was replicated three times under a randomized complete block design. The treatments comprised fixed doses of 120 and 150 kg N ha–1with different splits; variable doses based on sensor readings after application of 60, 90, and 120 kg N ha–1; 225 kg N ha–1as a nitrogen-rich control; and no application of nitrogen as the absolute control. It was revealed that the application of a basal dose of 60 kg N ha–1and another 60 kg N ha–1at the crown root initiation stage followed by a sensor-guided N application significantly improved wheat grain yields and grain nitrogen uptake. However, straw nitrogen uptake was highest in N-rich plots where 225 kg N ha–1was applied. It was found that any curtailment in these doses at basal and crown root initiation stages followed by nitrogen application using a normalized difference vegetation index sensor later could not bring about higher crop yields. On average, wheat crops responded to 152–155 kg N ha–1in both years of the study. Partial factor productivity along with agronomic and economic nitrogen use efficiency showed a declining trend with an increased rate of N application. Apparent N recovery values were comparable between normalized difference vegetation index sensor-based N application treatments and treatments receiving lesser N doses. Soil N status decreased in all the treatments except the nitrogen-rich strip, where there was a marginal increase in soil N status after the wheat crop harvest in the rotation. Partial nitrogen balance was negative for all the treatments except the control. From these 2-year field trials, it can be concluded that applying a normalized difference vegetation index sensor could be an essential tool for the rational management of fertilizer nitrogen in wheat grown in eastern sub-Himalayan plains.
Strong evidence for ideomotor theory: Unwilled manifestation of the conceptual attribute in movement control
Authors: Shin Yun Kyoung , Choe Seonggyu , Kwon Oh-Sang
Published: April 2023

Scientific understanding of how the mind generates bodily actions remains opaque. In the early 19th century, the ideomotor theory proposed that humans generate voluntary actions by imagining the sensory consequence of those actions, implying that the idea of an action’s consequence mediates between the intention to act and motor control. Despite its long history and theoretical importance, existing empirical evidence for the ideomotor theory is not strong enough to rule out alternative hypotheses. In this study, we devised a categorization-action task to evaluate ideomotor theory by testing whether an idea, distinguished from a stimulus, can modulate task-irrelevant movements. In Experiment 1, participants categorized a stimulus duration as long or short by pressing an assigned key. The results show that participants pressed the key longer when categorizing the stimulus as long than they did when characterizing it as short. In Experiment 2, we showed that the keypressing durations were not modulated by the decision category when the property of the decision category, the brightness of a stimulus, was not easily transferable to the action. In summary, our results suggest that while the perceived stimulus features have a marginal effect on response duration linearly, the decision category is the main factor affecting the response duration. Our results indicate that an abstract category attribute can strongly modulate action execution, constraining theoretical conjectures about the ideomotor account of how people voluntarily generate action.
The Experiences Surrounding Romantic Relationships of Korean Bisexual Individuals
Authors: Park Jeongeun , Chung Seojin
Published: April 2023

Introduction

In recent years, the level of social and academic interest in sexual minorities has been gradually increasing. However, studies on bisexual individuals and the data on experiences of bisexual individuals outside the United States are scarce.

Methods

To decrease the gap in the literature, this study examined the experiences of South Korean bisexual individuals in the context of romantic relationships via semi-structured, in-depth interviews. Participants were recruited through online-based platforms, and the interview with eight participants was analyzed.

Results

Five main themes were identified: discovering myself as bisexual, being exposed to discrimination and exclusion, being affected by the sex of a romantic partner, protecting myself when engaging in a romantic relationship, and benefits of a romantic relationship.

Discussion

The findings suggest that Korea’s heteronormative system and culture were the major challenges perceived by the participants. In conclusion, this study illustrates how sociocultural norms, social acceptance, and recognition affect bisexual identity in a romantic relationship.
The health benefits of bicycling to school among adolescents in China: A propensity score matching study
Authors: Ding Pengxiang , Ding Chang , Feng Suwei
Published: April 2023

Background

A large number of high-income countries are now promoting active commuting to school as an opportunity for adolescents to increase physical activity (PA) and improve their health. Few studies have examined the multiple benefits of active travel to school among adolescents in developing countries, especially in China. Hence, this study aims to estimate the effects of bicycling to school on adolescents’ subjective health, physical health, and sickness absence.

Methods

Self-reported and cross-sectional data from 6,353 school-aged children (12–19 years old) in the 2014–2015 China Education Panel Survey (CEPS2014-2015) were used. The independent variable was a binary, self-reported indicator of whether children bicycled to school. The dependent variables included subjective health (self-reported health, mental stress), physical health (BMI, kidney disease, lung disease, heart disease, brain disease, upper limb fracture, lower limb fracture, and sickness frequency), and sickness absence. Propensity score matching (PSM) was used to estimate the causal effects of bicycling to school on adolescents’ health.

Results

Bicycling to school positively affects both subjective and physical health. Those students who biked to school were associated with a higher self-rated health status, a healthier weight, a lower level of mental stress, and a lower risk of developing brain diseases. No significant relation is found between bicycling and sickness frequency, and sickness absence. Moreover, we separately compared the bicycling group with the walking group and the non-active travel group. There is still evidence that cycling is beneficial for students. Compared with walking to school, cycling to school resulted in a higher self-rated health score and a lower mental stress score. Physically, students who bicycled to school were less likely to be absent from school and suffer from kidney and brain diseases than students who walked to school. However, we do not find a significant difference in health outcomes from cycling compared to non-active modes of transportation. Further, differentiation of the health effects of bicycling across living areas shows that health effects are more pronounced for those living in edge and rural areas.

Conclusion

These findings provide evidence of the value of promoting bicycling to school in improving various adolescents’ health outcomes in transitional China.
Age- and sex-specific associations between sarcopenia severity and poor cognitive function among community-dwelling older adults in Japan: The IRIDE Cohort Study
Authors: Ohta Takahisa , Sasai Hiroyuki , Osuka Yosuke , Kojima Narumi , Abe Takumi , Yamashita Mari , Obuchi Shuichi P. , Ishizaki Tatsuro , Fujiwara Yoshinori , Awata Shuichi , Toba Kenji ,   IRIDE Cohort Study Investigators
Published: April 2023

Introduction

This study examined whether the association between sarcopenia severity and cognitive function differed according to sex and age in community-dwelling older adults in Japan.

Methods

This is a cross-sectional study of older adults (age ≥ 65 years) consisting of five regional cohorts integrated as the Integrated Research Initiative for Living Well with Dementia (IRIDE) Cohort Study. Sarcopenia severity was determined based on the Asian Working Group for Sarcopenia 2019, which assessed grip strength, walking speed, and skeletal muscle mass index. Poor cognitive function was defined as a Mini-Mental State Examination score of ≤ 23. Odds ratios (ORs) and 95% confidence intervals (CIs) for poor cognitive function were calculated by sex and age group (65–74 and ≥75 years) using binomial logistic regression models, which were adjusted for age, educational attainment, history of non-communicable diseases, smoking and drinking habits, living alone, frequency of going outdoors, exercise habits, and depressive symptom.

Results

Of the 8,180 participants, 6,426 (1,157 men aged 65–74 and 1,063 men aged 75 or older; 2,281 women aged 65–74 and 1,925 women aged 75 or older) were analyzed. The prevalence ratio of sarcopenia and severe sarcopenia were 309 (13.9%) and 92 (4.1%) among men and 559 (13.3%) and 166 (3.7%) among women, respectively. A total of 127 (5.8%) men and 161 (3.9%) women had a poor cognitive function. Setting non-sarcopenia as a reference, the adjusted ORs (95% CI) of poor cognitive function were 2.20 (1.54, 3.15) for sarcopenia and 3.56 (2.20, 5.71) for severe sarcopenia. A similar trend was observed in analyses stratified by sex and age, with linear associations (P for trend <0.05) in both categories. Furthermore, there was a significant interaction (P < 0.05) between sex and sarcopenia severity, indicating a stronger linear association of sarcopenia severity with poor cognitive function in women compared with men.

Discussion and conclusion

Sarcopenia severity was linearly associated with poor cognitive function in adults aged ≥ 65 years, with a stronger association in women compared with men.
Consideration of sex/gender in publications of quantitative health-related research: Development and application of an assessment matrix
Authors: Horstmann Sophie , Hartig Christina , Kraus Ute , Palm Kerstin , Jacke Katharina , Dandolo Lisa , Schneider Alexandra , Bolte Gabriele
Published: April 2023

During the last years the need to integrate sex and gender in health-related research for better and fairer science became increasingly apparent. Various guidelines and checklists were developed to encourage and support researchers in considering the entangled dimensions of sex/gender in their research. However, a tool for the assessment of sex/gender consideration and its visualization is still missing. We aim to fill this gap by introducing an assessment matrix that can be used as a flexible instrument for comprehensively evaluating the sex/gender consideration in quantitative health-related research. The matrix was developed through an iterative and open process based on the interdisciplinary expertise represented in our research team and currently published guidelines. The final matrix consists of 14 different items covering the whole research process and the publication of results. Additionally, we introduced a method to graphically display this evaluation. By developing the matrix, we aim to provide users with a tool to systematically compare sex/gender consideration qualitatively between different publications and even different fields of study. This way, the assessment matrix represents a tool to identify research gaps and a basis for future research. In the long term, the implementation of this tool to evaluate the consideration of sex/gender should contribute to more sex/gender equitable health-related research.
Biopriming of cucumber seeds using actinobacterial formulas as a novel protection strategy against Botrytis cinerea
Authors: Jurado Macarena M. , Suárez-Estrella Francisca , Toribio Ana J. , Martínez-Gallardo María R. , Estrella-González María J. , López-González Juan A. , López María J.
Published: April 2023

This work highlights the ability of various actinobacterial formulas, to control the incidence of gray-mold caused by Botrytis cinerea in cucumber seedlings. Protocols applied aimed at the preliminary characterization of the actinobacterial collection and the biopolymers used as carriers were very useful for predicting their phytotoxic, phytostimulating and biopesticidal capacity. First, the phytostimulatory or phytotoxic potential of 3 biopolymers at 3 different concentrations and a collection of 10 actinobacteria were analyzed by calculating the germination index in cucumber seeds by seed dipping (biopriming). In general, two-member consortia and independent actinobacteria previously selected reached a phytostimulant effect on cucumber seedlings after their application by biopriming. Likewise, the selected actinobacteria were characterized, sole and in co-cultures, according to its ability to inhibit the growth of B. cinerea by dual culture bioassays. Finally, after selecting the most effective actinobacterial formulas, a preventive gray-mold bioassay was performed based on cucumber seed biopriming. The strains A5 and A7, in axenic and co-culture, showed to be the most efficient strains against the in vitro growth of B. cinerea. Seed biopriming strategy with actinobacterial formulas revealed a remarkable promoter effect in the early stages of plant development and after the infection with the phytopathogen fungus was remained. Definitely, the microbial formulas used in this work showed a phytostimulant and biopesticide character, laying the foundations for subsequent studies that allow a deeper scrutiny of the mechanisms of action that grant the specialization of the effect that occurs between beneficial microorganisms and specific plant hosts.
Safety and efficacy of esketamine for postoperative analgesia in pediatric patients with hypospadias
Authors: Xu Yong , Chen Quan , Li Ping , Song Xingrong
Published: April 2023

Objective

To explore the safety and efficacy of the combination of continuous intravenous infusion of esketamine with sacral block for postoperative analgesia in pediatric patients undergoing surgery for hypospadias

Methods

Pediatric patients (n = 77) undergoing surgery for hypospadias were randomized into two groups: a hydromorphone group (H group, initial dose, 0.02 mg/kg; maintenance dose, 0.01 mg/kg/h) or an esketamine group (E group, initial dose, 0.3 mg/kg; maintenance dose 0.15 mg/kg/h). Caudal epidural block involved injection of 0.2% ropivacaine 1 ml/kg through the sacral hiatus. Age, weight, grade of hypospadias, intraoperative blood loss, operative time, and awaking time of patients were recorded. The Face, Legs, Activity, Cry and Consolability (FLACC) scale and Ramsay sedation scores were recorded when leaving the PACU (0 h) and at postoperative 2, 6, 12, 24, 36, and 48 h. The Pediatric Anesthesia Emergence Delirium Scale (PAED), incidence of hypotension, respiratory depression, nausea and vomiting and pruritus, and the time to first bowel movement after surgery were recorded.

Results

There were no significant differences in demographic and clinical characteristics between the H group and the E group. There were no significant differences in FLACC scores at postoperative 0, 2, 6, 12, 24, 36, and 48 h in intra-group and inter-group comparisons. There were no significant differences in Ramsay sedation scores at postoperative 0, 2, 6, 12, 24, 36, and 48 h in the intra-group comparisons. Ramsay sedation scores were significantly lower at postoperative 2, 12, and 36 h in the H group compared to the E group. There were no significant differences in the PAED scale or incidence of nausea and vomiting or pruritus between the H group and the E group. The incidence of hypotension and respiratory depression was significantly lower, and the time to first bowel movement was significantly shorter in the E group compared to the H group. Urinary tryptophan, 5-hydroxytryptamine and substance P levels were significantly lower but arginine was significantly higher in the E group compared to the H group.

Conclusions

The combination of continuous intravenous infusion of esketamine with sacral block provided safe and effective postoperative analgesia for pediatric patients undergoing surgery for hypospadias.

Trial registration

Chinese Clinical Trial Register ChiCTR2200066967. Clinical trial registry URL: http://www.chictr.org.cn/edit.aspx?pid=185042&htm=4
A neuroscience-based approach to the assessment of sexual behavior in animals
Authors: Tekin Samet , Akgün Elif Ece , Ömür Ali Doğan
Published: April 2023

Sexual behavior in animals is important in ensuring the continuity of the generation. These behaviors differ in animal species. Sexual behaviors are shaped under the control of the reproductive system. Physiological stimuli produced by the reproductive system find their counterparts in the organism as reproductive activity. Reproductive activity display a critical role by transferring on the genetic heritage of organisms to the next generations. This activity, which is built on delicate balances, is associated with many systems in the organism. Nervous system, hormonal system, and circulatory system are the main ones. The regular formation of the reproductive activity in species is due to the effect of various factors. In domestic mammals, the reproductive activity is regulated by hormones secreted from brain and endocrine glands. Many hormones have duties in terms of the sustainability of reproductive activity. GnRH is the main hormone responsible for initiating this reproductive activity. Gonadotropin-releasing hormone (GnRH), which is a small molecule peptide from certain nerve cells in the nucleus infundibularis region of the hypothalamus and consists of different amino acids, is secreted under the influence of smell, temperature, light, and physical stimulation. Besides, GnRH release is controlled by various neurotransmitters (adrenaline, noradrenaline, dopamine, acetylcholine, serotonin). On the other hand, various genetic factors in secretory glands, gonadal cells, reproductive tissues can lead to significant changes on reproductive activity through specific molecular pathways and mechanisms.
Air Traffic Complexity Evaluation with Hierarchical Graph Representation Learning
Authors: Zhang Lu , Yang Hongyu , Wu Xiping
Published: April 2023

Air traffic management (ATM) relies on the running condition of the air traffic control sector (ATCS), and assessing whether it is overloaded is crucial for efficiency and safety for the entire aviation industry. Previous approaches to evaluating air traffic complexity in a sector were mostly based on aircraft operational status and lacked comprehensiveness of characterization and were less adaptable in real situations. To settle these issues, a deep learning technique grounded on complex networks was proposed, employing the flight conflict network (FCN) to generate an air traffic situation graph (ATSG), with the air traffic control instruction (ATCOI) received by each aircraft included as an extra node attribute to increase the accuracy of the evaluation. A pooling method with a graph neural network (GNN) was used to analyze the graph-structured air traffic information and produce the sector complexity rank automatically. The model Hierarchical Graph Representing Learning (HGRL) was created to build comprehensive feature representations which involve two parts: graph structure coarsening and graph attribute learning. Structure coarsening reduced the feature map size by choosing an adaptive selection of nodes, while attribute coarsening selected key nodes in the graph-level representation. The experimental findings of a real dataset from the Chinese aviation industry reveal that our proposed model exceeds prior methods in its ability to extract critical information from an ATSG. Moreover, our work could be applied in the two main types of sectors and without extra factor calculations to determine the complexity of the airspace.
Fine-Grained Detection of Pavement Distress Based on Integrated Data Using Digital Twin
Authors: Wang Weidong , Xu Xinyue , Peng Jun , Hu Wenbo , Wu Dingze
Published: April 2023

The automated detection of distress such as cracks or potholes is a key basis for assessing the condition of pavements and deciding on their maintenance. A fine-grained pavement distress-detection algorithm based on integrated data using a digital twin is proposed to solve the challenges of the insufficiency of high-quality negative samples in specific scenarios An asphalt pavement background model is created based on UAV-captured images, and a lightweight physical engine is used to randomly render 5 types of distress and 3 specific scenarios to the background model, generating a digital twin model that can provide virtual distress data. The virtual data are combined with real data in different virtual-to-real ratios (0:1 to 5:1) to form an integrated dataset and used to fully train deep object detection networks for fine-grained detection. The results show that the YOLOv5 network with the virtual-to-real ratio of 3:1 achieves the best average precision for 5 types of distress (asphalt pavement MAP: 75.40%), with a 2-fold and 1.5-fold improvement compared to models developed without virtual data and with traditional data augmentation, respectively, and achieves over 40% recall in shadow, occlusion and blur. The proposed approach could provide a more reliable and refined automated method for pavement analysis in complex scenarios.
The Mesoscopic Numerical Simulation of GAP/CL20/AP Composite Solid Propellant Based on MPM and FEM
Authors: Gu Xiaoyong , Liu Xiangyang , Dong Chunying , Zhang Guanglong , Zhang Liming , Zhang Fengjian
Published: April 2023

In this paper, first, the meso-debonding process of a GAP/CL20/AP composite solid propellant under uniaxial tension was analyzed using the advantages of the material point method (MPM) and the finite element method (FEM) for the first time; then, the numerical simulation results were compared with the experiments. Based on the basic principle of modeling with the material point method, grains of different sizes were generated quickly and efficiently. Next, the grains were dispersed into particles, and the position information of the particles was mapped onto the background grid, so the background grids were used to determine the position of the grains. After that, the generated AP and CL20 grains were imported into the commercial software Abaqus through python scripting codes for numerical calculation. Based on macro-mechanical tests and a micro-numerical simulation, this paper studies the micro-internal mechanism that affects the macro-mechanical properties of composite solid propellants. Three interface parameters needed to be determined by parameter inversion, and the value of the objective interpolation function minR was 0.05078%. From a comparison, it was found that the numerical simulation results are in good agreement with the experimental results in the aspects of micro-crack cracking characteristics and the nominal stress–strain curve of propellants. After that, the influence of interface parameters on the stress–strain curve are discussed. The research in this paper has high scientific value and engineering application value and can provide important reference and guidance for the design of composite solid propellants and its mechanical property analyses, so as to solve the structural integrity problem of solid rocket motor charges.