bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of blinatumomab in children with relapsed/refractory B cell acute lymphoblastic leukemia: A systematic review and meta-analysis
Authors: Chen Bin , Zou Zhuan , Zhang Qian , Chen Kexing , Zhang Xiaoyan , Xiao Dongqiong , Li Xihong
Published: January 2023

Objectives: Several clinical trials have been conducted to evaluate the effects of blinatumomab in childhood B cell acute lymphoblastic leukemia (B-ALL). We conducted this meta-analysis to validate the efficacy and safety of blinatumomab in pediatric patients with relapsed/refractory B-ALL (R/R B-ALL).

Methods: We searched and investigated all relevant studies in the PubMed, Web of Science, Embase, and Cochrane Library databases. The primary outcomes were complete response (CR), overall survival (OS), event free survival (EFS), minimal residual disease (MRD) response, allogeneic hematopoietic stem cell transplantation (allo-HSCT) and were calculated separately for randomized controlled trials (RCTs) and single-arm studies. The secondary end points were adverse effects (AEs) and the relapse rate. The Cochrane, bias assessment tool, was used to assess the risk of bias in RCTs. The methodological quality of single-arm studies was assessed using the methodological index for non-randomized studies (MINORS) tool.

Results: The meta-analysis included two RCTs and 10 single-arm studies, including 652 patients in total. Our study showed that in the single-arm studies, the combined CR rate was 0.56 (95% confidence interval (CI): 0.45 -0.68), the odds ratios (ORs) of OS was 0.43 (95% CI 0.32 -0.54), the EFS rate was 0.30 (95% CI: 0.20 -0.40), the MRD response was 0.51 (95% CI: 0.34 -0.68), allo-HSCT rate was 0.62 (95% CI: 0.50 -.74), the AE rate was 0.65 (95% CI: 0.54 -0.76) and the relapse rate was 0.32 (95% CI: 0.27 -0.38). In the RCTs, the blinatumomab-treated group compared with the chemotherapy group had a combined OS rate of 0.12 (95% CI: 0.05 -0.19) and an EFS rate of 2.16 (95% CI: 1.54 -3.03). The pooled MRD response rate was 4.71 (95% CI:2.84 -7.81), allo-HSCT was 3.24 (95% CI: 1.96 -5.35), the AE rate was 0.31 (95% CI: 0.16 -0.60), and the relapse rate was 0 .69 (95% CI: 0.43 -1.09).

Conclusion: According to this meta-analysis, blinatumomab shows potent therapeutic efficacy and limited AEs in children with R/R B- ALL.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42022361914.
A systematic review of antibacterial activity of polyphenolic extract from date palm (Phoenix dactylifera L.) kernel
Authors: Bhaskaracharya Raman K. , Bhaskaracharya Archana , Stathopoulos Constantinos
Published: January 2023

Background: Emergence of antibiotic-resistant bacteria makes exploration of natural antibacterial products imperative. Like other fruit processing industry by-products, date kernels, a waste from date processing industry is rich in its extractable polyphenols. The rich polyphenolic content suggests that date kernel extracts (DKE) can be a cost-effective source of antimicrobial agents, however, their antibacterial activity is poorly understood. Hence, a systematic review of available literature to establish DKE’s antibacterial activity is warranted.

Methods: A systematic PRISMA approach was employed, and relevant studies were identified using defined keywords from Google Scholar, Scopus, PubMed, and Web of Science databases. The search results were screened based on predefined eligibility criteria and data extraction, organization, pooling, and descriptive statistical analyses of original research records conducted.

Results: A total of 888 published records were retrieved from databases. Preliminary screening by applying specific eligibility criteria reduced records to 96 which after full text screening further decreased to 14 records. Escherichia coli and Staphylococcus aureus were the most studied organisms. Results indicate moderate to highly active effect shown by the less polar solvent based DKE’s against Gram-positive and by the aqueous based DKE’s against Gram-negative bacteria. The review confirms antibacterial activity of DKE against both Gram-positive and -negative bacteria. Heterogeneity in reported polyphenolic content and antibacterial activity are due to differences in cultivars, extraction methods, test methods, model organisms, etc. Use of standardized protocols for isolation, characterization, testing of DKE’s active polyphenols to elucidate its antibacterial activity is recommended to establish the clinical efficacy of natural antibacterial compounds from DKE.

Conclusion: This review outlines the current knowledge regarding antibacterial activity of polyphenolic DKE, identifying gaps in information and provides key recommendations for future research directions.
A novel cuproptosis-related prognostic gene signature and validation of differential expression in hepatocellular carcinoma
Authors: Li Yaoting , Zeng Xuezhen
Published: January 2023

Background: Cuproptosis is a newly discovered form of programmed cell death, which is characterized by accumulation of intra-cellular copper ion leading to the aggregation of lipoproteins and destabilization of Fe-S cluster proteins in mitochondrial metabolism, thereby affecting the prognosis of patients with cancer. However, the role of cuproptosis-related genes (CRGs) in hepatocellular carcinoma (HCC) remains elusive.

Methods: Mutation signature, copy number variation and the expression of 10 CRGs were assessed in HCC from TCGA-LIHC dataset. ICGC-LIRI-JP dataset was used as further validation cohort. The least absolute shrinkage and selection operator (LASSO) was used to construct the prognostic model. Kaplan Meier curves, time-ROC curves, nomogram, univariate and multivariate Cox regression were utilized to evaluate the predictive efficacy of CRGs-score. Immune infiltration was analyzed by CIBERSOFT, ssGSEA algorithm, and TIMER database. The expression of prognostic CRGs was validated by qPCR both in-vitro and in-vivo. Drug sensitivity analysis was performed by pRRophetic.

Results: All of the CRGs were differentially expressed in HCC and 5 out of them (CDKN2A, DLAT, GLS, LIPT1, MTF1) correlated with patient survival. These signature genes were selected by LASSO analysis to establish a prognosis model to stratify HCC patients into high and low CRGs-score subgroups. High CRGs-score was associated with a worse prognosis. Subsequently, univariate and multivariate Cox regression verified that CRGs-score was an independent cancer risk factor that correlated with clinical factors including stage and grade. Nomogram integrating the CRGs-score and clinical risk factors performed well to predict patient survival. Immune infiltration analysis further revealed that the expression of immune checkpoint genes was significantly enhanced in high CRGs-score group, especially PD-1 and PD-L1. An independent validation cohort (ICGC) confirmed that CRGs-score as a stable and universally applicable indicator in predicting HCC patient survival. Concordantly, the expression of five confirmed signature genes were also differentially expressed in human HCC cell lines and mouse HCC model. In addition, we also analyzed the sensitivity of 10 clinical targeted therapies between high and low CRGs-score groups.

Conclusion: This study elucidated the role of dysregulated CRGs in HCC cohort, with validation with in-vitro and in-vivo models. The CRGs-score might be applied as a novel prognostic factor in HCC.
Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level
Authors: Wu Hong , Xie Cheng , Wang Ruilin , Cheng Jun , Xu Qingbo , Zhao Haige
Published: January 2023

Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms. Sustained subcutaneous angiotensin II infusion can induce aortic aneurysms in mice. However, the relevance of using angiotensin II induction model to study aneurysm disease and the degree of commonality between species remain elusive.

Methods: We utilized scRNA-seq to infer aortic cell sub-structures and transcriptional profiles in clinical patient TAAs and AAAs, as well as mouse models of corresponding diseases (Ang II induction) and in healthy mouse aorta. Unbiased comparison between mice and humans explored the possible reasonability and utility of mouse Ang II-induced aortic aneurysm as a model for human aortic aneurysm diseases. Meanwhile, we performed comparative analysis of aortic aneurysms between TAA and AAA in both organisms.

Results and Discussion: We demonstrated similarities and differences of changes in the components of human and mouse cell types, and our unbiased comparison between mouse and human identified well conserved subpopulations of SMCs and macrophages. Furthermore, the results of our comparative analyses suggested different biological functions and distinct potential pathogenic genes for thoracic and abdominal aortic aneurysms. MIF and SPP1 signaling networks participated in aortic aneurysm in both organisms. This study maps aortic aneurysm and offers opportunities for future researches to investigate the potential of subpopulations or marker genes as therapy targets.
Measurement and reconstruction of geometric parameters of the barrel bore based on the laser scanning strategy
Authors: Zhang Pengjun , Jin Wei , Ren Dongdong , Lyu Yunfei
Published: January 2023

The inner surface defects can be displayed intuitively by measuring the geometric parameters of rifling of the artillery barrel. In this paper, the parameters of the barrel bore were scanned based on the high-precision laser, and the three-dimensional reconstruction of the bore shape was conducted based on the test data. The wavelet transform was used for multiple de-noising of the test data, and the Delaunay triangulation interpolation algorithm was used to reconstruct the three-dimensional contour structure of the barrel bore, forming a high-fidelity measurement strategy for the parameters of the barrel bore. The results show that this measurement strategy can achieve the high-precision measurement of the geometric parameters of barrel rifling, and the accuracy can reach .001 mm. By comparing the measured value of rifling with the standard value, the flaw points in the rifling of the birth tube can be accurately specified. The three-dimensional model reconstruction based on the massive sample data realizes the high-fidelity measurement of rifling geometric parameters. This measurement strategy can provide support for the visualization of barrel rifling and effectively improve the detection accuracy of the barrel bore.
Neuregulin 4 as a novel adipokine in energy metabolism
Authors: Liu Yuanbin , Chen Mingkai
Published: January 2023

Adipose tissue has been shown to play a key role in energy metabolism and it has been shown to regulate metabolic homeostasis through the secretion of adipokines. Neuregulin 4 (Nrg4), a novel adipokine secreted mainly by brown adipose tissue (BAT), has recently been characterized as having an important effect on the regulation of energy homeostasis and glucolipid metabolism. Nrg4 can modulate BAT-related thermogenesis by increasing sympathetic innervation of adipose tissue and therefore has potential metabolic benefits. Nrg4 improves metabolic dysregulation in various metabolic diseases such as insulin resistance, obesity, non-alcoholic fatty liver disease, and diabetes through several mechanisms such as anti-inflammation, autophagy regulation, pro-angiogenesis, and lipid metabolism normalization. However, inconsistent findings are found regarding the effects of Nrg4 on metabolic diseases in clinical settings, and this heterogeneity needs to be further clarified by future studies. The potential metabolic protective effect of Nrg4 suggests that it may be a promising endocrine therapeutic target.
Habituation of the stress response multiplex to repeated cold pressor exposure
Authors: Bullock Tom , MacLean Mary H. , Santander Tyler , Boone Alexander P. , Babenko Viktoriya , Dundon Neil M. , Stuber Alexander , Jimmons Liann , Raymer Jamie , Okafor Gold N. , Miller Michael B. , Giesbrecht Barry , Grafton Scott T.
Published: January 2023

Humans show remarkable habituation to aversive events as reflected by changes of both subjective report and objective measures of stress. Although much experimental human research focuses on the effects of stress, relatively little is known about the cascade of physiological and neural responses that contribute to stress habituation. The cold pressor test (CPT) is a common method for inducing acute stress in human participants in the laboratory; however, there are gaps in our understanding of the global state changes resulting from this stress-induction technique and how these responses change over multiple exposures. Here, we measure the stress response to repeated CPT exposures using an extensive suite of physiologic measures and state-of-the-art analysis techniques. In two separate sessions on different days, participants underwent five 90 s CPT exposures of both feet and five warm water control exposures, while electrocardiography (ECG), impedance cardiography, continuous blood pressure, pupillometry, scalp electroencephalography (EEG), salivary cortisol and self-reported pain assessments were recorded. A diverse array of adaptive responses are reported that vary in their temporal dynamics within each exposure as well as habituation across repeated exposures. During cold-water exposure there was a cascade of changes across several cardiovascular measures (elevated heart rate (HR), cardiac output (CO) and Mean Arterial Pressure (MAP) and reduced left ventricular ejection time (LVET), stroke volume (SV) and high-frequency heart rate variability (HF)). Increased pupil dilation was observed, as was increased power in low-frequency bands (delta and theta) across frontal EEG electrode sites. Several cardiovascular measures also habituated over repeated cold-water exposures (HR, MAP, CO, SV, LVET) as did pupil dilation and alpha frequency activity across the scalp. Anticipation of cold water induced stress effects in the time-period immediately prior to exposure, indexed by increased pupil size and cortical disinhibition in the alpha and beta frequency bands across central scalp sites. These results provide comprehensive insight into the evolution of a diverse array of stress responses to an acute noxious stressor, and how these responses adaptively contribute to stress habituation.
Utilizing evolutionary conservation to detect deleterious mutations and improve genomic prediction in cassava
Authors: Long Evan M. , Romay M. Cinta , Ramstein Guillaume , Buckler Edward S. , Robbins Kelly R.
Published: January 2023

Introduction

Cassava (Manihot esculenta) is an annual root crop which provides the major source of calories for over half a billion people around the world. Since its domestication ~10,000 years ago, cassava has been largely clonally propagated through stem cuttings. Minimal sexual recombination has led to an accumulation of deleterious mutations made evident by heavy inbreeding depression.

Methods

To locate and characterize these deleterious mutations, and to measure selection pressure across the cassava genome, we aligned 52 related Euphorbiaceae and other related species representing millions of years of evolution. With single base-pair resolution of genetic conservation, we used protein structure models, amino acid impact, and evolutionary conservation across the Euphorbiaceae to estimate evolutionary constraint. With known deleterious mutations, we aimed to improve genomic evaluations of plant performance through genomic prediction. We first tested this hypothesis through simulation utilizing multi-kernel GBLUP to predict simulated phenotypes across separate populations of cassava.

Results

Simulations showed a sizable increase of prediction accuracy when incorporating functional variants in the model when the trait was determined by<100 quantitative trait loci (QTL). Utilizing deleterious mutations and functional weights informed through evolutionary conservation, we saw improvements in genomic prediction accuracy that were dependent on trait and prediction.

Conclusion

We showed the potential for using evolutionary information to track functional variation across the genome, in order to improve whole genome trait prediction. We anticipate that continued work to improve genotype accuracy and deleterious mutation assessment will lead to improved genomic assessments of cassava clones.
Global transcriptome and targeted metabolite analyses of roots reveal different defence mechanisms against Ralstonia solanacearum infection in two resistant potato cultivars
Authors: Jose Jeny , Éva Csaba , Bozsó Zoltán , Hamow Kamirán Áron , Fekete Zsófia , Fábián Attila , Bánfalvi Zsófia , Sági László
Published: January 2023

Ralstonia solanacearum (Rs), the causal agent of bacterial wilt disease in an unusually wide range of host plants, including potato (Solanum tuberosum), is one of the most destructive phytopathogens that seriously reduces crop yields worldwide. Identification of defence mechanisms underlying bacterial wilt resistance is a prerequisite for biotechnological approaches to resistance breeding. Resistance to Rs has been reported only in a few potato landraces and cultivars. Our in vitro inoculation bioassays confirmed that the cultivars ‘Calalo Gaspar’ (CG) and ‘Cruza 148’ (CR) are resistant to Rs infection. Comparative transcriptome analyses of CG and CR roots, as well as of the roots of an Rs-susceptible cultivar, ‘Désirée’ (DES), were carried out two days after Rs infection, in parallel with their respective noninfected controls. In CR and DES, the upregulation of chitin interactions and cell wall-related genes was detected. The phenylpropanoid biosynthesis and glutathione metabolism pathways were induced only in CR, as confirmed by high levels of lignification over the whole stele in CR roots six days after Rs infection. At the same time, Rs infection greatly increased the concentrations of chlorogenic acid and quercetin derivatives in CG roots as it was detected using ultra-performance liquid chromatography − tandem mass spectrometry. Characteristic increases in the expression of MAP kinase signalling pathway genes and in the concentrations of jasmonic, salicylic, abscisic and indoleacetic acid were measured in DES roots. These results indicate different Rs defence mechanisms in the two resistant potato cultivars and a different response to Rs infection in the susceptible cultivar.
Precision detection of crop diseases based on improved YOLOv5 model
Authors: Zhao Yun , Yang Yuan , Xu Xing , Sun Cheng
Published: January 2023

Accurate identification of crop diseases can effectively improve crop yield. Most current crop diseases present small targets, dense numbers, occlusions and similar appearance of different diseases, and the current target detection algorithms are not effective in identifying similar crop diseases. Therefore, in this paper, an improved model based on YOLOv5s was proposed to improve the detection of crop diseases. First, the CSP structure of the original model in the feature fusion stage was improved, and a lightweight structure was used in the improved CSP structure to reduce the model parameters, while the feature information of different layers was extracted in the form of multiple branches. A structure named CAM was proposed, which can extract global and local features of each network layer separately, and the CAM structure can better fuse semantic and scale inconsistent features to enhance the extraction of global information of the network. In order to increase the number of positive samples in the model training process, one more grid was added to the original model with three grids to predict the target, and the formula for the prediction frame centroid offset was modified to obtain the better prediction frame centroid offset when the target centroid falled on the special point of the grid. To solve the problem of the prediction frame being scaled incorrectly during model training, an improved DIoU loss function was used to replace the GIoU loss function used in the original YOLOv5s. Finally, the improved model was trained using transfer learning, the results showed that the improved model had the best mean average precision (mAP) performance compared to the Faster R-CNN, SSD, YOLOv3, YOLOv4, YOLOv4-tiny, and YOLOv5s models, and the mAP, F1 score, and recall of the improved model were 95.92%, 0.91, and 87.89%, respectively. Compared with YOLOv5s, they improved by 4.58%, 5%, and 4.78%, respectively. The detection speed of the improved model was 40.01 FPS, which can meet the requirement of real-time detection. The results showed that the improved model outperformed the original model in several aspects, had stronger robustness and higher accuracy, and can provide better detection for crop diseases.
The COPII subunit MoSec24B is involved in development, pathogenicity and autophagy in the rice blast fungus
Authors: Qian Hui , Sun Lixiao , Wu Minghua , Zhao Wenhui , Liu Mengyu , Liang Shuang , Zhu Xueming , Li Lin , Su Zhenzhu , Lu Jianping , Lin Fucheng , Liu Xiaohong
Published: January 2023

The endoplasmic reticulum (ER) acts as the starting point of the secretory pathway, where approximately one-third of the proteins are correctly folded and modified, loaded into vesicles, and transported to the Golgi for further processing and modification. In this process, COPII vesicles are responsible for transporting cargo proteins from the ER to the Golgi. Here, we identified the inner shell subunit of COPII vesicles (MoSec24B) and explored the importance of MoSec24B in the rice blast fungus. The targeted disruption of MoSec24B led to decreased growth, reduced conidiation, restricted glycogen and lipids utilization, sensitivity to the cell wall and hypertonic stress, the failure of septin-mediated repolarization of appressorium, impaired appressorium turgor pressure, and decreased ability to infect, which resulted in reduced pathogenicity to the host plant. Furthermore, MoSec24B functions in the three mitogen-activated protein kinase (MAPK) signaling pathways by acting with MoMst50. Deletion of MoSec24B caused reduced lipidation of MoAtg8, accelerated degradation of exogenously introduced GFP-MoAtg8, and increased lipidation of MoAtg8 upon treatment with a late inhibitor of autophagy (BafA1), suggesting that MoSec24B regulates the fusion of late autophagosomes with vacuoles. Together, these results suggest that MoSec24B exerts a significant role in fungal development, the pathogenesis of filamentous fungi and autophagy.
Integrated diagnosis and time-series sensitivity evaluation of nutrient deficiencies in medicinal plant (Ligusticum chuanxiong Hort.) based on UAV multispectral sensors
Authors: Li Wenbo , Wang Ke , Han Guiqi , Wang Hai , Tan Ningbo , Yan Zhuyun
Published: January 2023

Background

Nitrogen(N), phosphorus(P), and potassium(K) are essential elements that are highly deficient during plant growth. Existing diagnostic methods are not suitable for rapid diagnosis of large-scale planting areas. Near-ground remote sensing technology based on unmanned aerial vehicle (UAV) and sensor is often applied to crop growth condition monitoring and agricultural management. It has been proven to be used for monitoring plant N, P, and K content. However, its integrated diagnostic model has been less studied.

Methods

In this study, we collected UAV multispectral images of Ligusticum chuanxiong Hort. in different periods of nutritional stress and constructed recognition models with different heights and algorithms. The optimal model variables were selected, and the effects of different sampling heights and modeling algorithms on the model efficiency under the time span were evaluated. At the same time, we evaluated the timeliness of the model based on leaf element content determination and SPAD. It was also validated in field crop production.

Results

The results showed that the LR algorithm’s model had optimal performance at all periods and flight altitudes. The optimal accuracy of N-deficient plants identification reached 100%, P/K-deficient plants reached 92.4%, and normal plants reached 91.7%. The results of UAV multispectral diagnosis, chemical diagnosis, and SPAD value diagnosis were consistent in the diagnosis of N deficiency, and the diagnosis of P and K deficiency was slightly lagging behind that of chemical diagnosis.

Conclusions

This research uses UAV remote sensing technology to establish an efficient, fast, and timely nutritional diagnosis method for L. Chuanxiong, which is applied in production. Meanwhile, the standardized production of medicinal plant resources provides new solutions.
Characterization of cadmium accumulation mechanism between eggplant (Solanum melongena L.) cultivars
Authors: Shen Chuang , Huang Ying-Ying , Liao Qiong , Huang Bai-Fei , Xin Jun-Liang , Wang Luo , Fu Hui-Ling
Published: January 2023

Excessive cadmium (Cd) accumulation in vegetables due to farmland pollution constitutes a serious threat to human health. Eggplant has a tendency to accumulate Cd. To investigate the mechanism of the differences in Cd accumulation levels between high-Cd (BXGZ) and low-Cd (MYQZ) eggplant cultivar, physiological and biochemical indicators and mRNA expression of eggplant were examined using photosynthetic apparatus, biochemical test kits, Fourier transform infrared (FTIR) spectroscopy and transcriptome sequencing, etc. The results of biochemical test kits and FTIR revealed that MYQZ enhanced pectin methylesterase (PME) activity, and lignin and pectin content in the root cell wall, which was associated with the upregulation of PME, cinnamyl-alcohol dehydrogenase and peroxidase (PODs). Higher levels of cysteine and glutathione (GSH) contents and upregulation of genes associated with sulfur metabolism, as well as higher expression of ATP-binding cassette transporters (ABCs), cation exchangers (CAX) and metal tolerance proteins (MTPs) were observed in MYQZ. In BXGZ, the higher stomatal density and stomatal aperture as well as higher levels of Ca2+ binding protein-1 (PCaP1) and aquaporins and lower levels of A2-type cyclins (CYCA2-1) are consistent with an enhanced transpiration rate in BXGZ. Furthermore, a more developed root system was shown to be associated with higher levels of auxin response factor (ARF19), GATA transcription factors (GATA4, 5 and 11) and auxin efflux carrier component (PIN5) in BXGZ. In conclusion, highly active PME, and higher levels of lignin and pectin in MYQZ are expected to reduce Cd toxicity, while Cd translocation can be inhibited with the help of ABC and other Cd transporters. As for BXGZ, the uptake and translocation of Cd were enhanced by the developed root system and stronger transpiration.
Influence of fear of COVID-19 on depression: The mediating effects of anxiety and the moderating effects of perceived social support and stress perception
Authors: Li Xiaoyu , Yang Pengcheng , Jiang Yanju , Gao Dongdong
Published: January 2023

Objective

Explore the influence of fear of COVID-19 on depression, with anxiety as a mediator and perceived social support and stress perception as moderates.

Methods

From February to March 2020, 1,196 valid data were collected online through questionnaire by cluster sampling method. Fear of COVID-19 Questionnaire, the Patient Health Questionnaire 9-Item Scale (PHQ-9), the Generalized Anxiety Disorder 7-Item Scale (GAD-7), the Perceived Social Support Scale (PSSS) and the10-item Perceived Stress Scale (PSS-10) were used as the survey instrument, and the participants were female undergraduates from a liberal arts college of a Chinese university. Common method bias was assessed using Harman’s single-factor test in SPSS and confirmatory factor analysis in AMOS. The levels of participants’ anxiety, depression and perceived social support were described using frequency and percentage, Pearson Correlation test was used to measure the correlation between the variables. The PROCESS macro for SPSS (Model 1, Model 4, and Model 21) were applied to examine the mediating effect and moderating effect of the model.

Results

Fear of COVID-19 can positively influence depression, anxiety plays a mediating role between fear of COVID-19 and depression, perceived social support negatively moderates the relationship between fear of COVID-19 and anxiety, and stress perception positively moderates the relationship between anxiety and depression. These five variables can form a moderated mediating effect model.

Conclusion

Fear of COVID-19, anxiety and stress perception are risk factors for depression, perceived social support is a protective factor for depression. Reducing the fear of COVID-19, anxiety and stress perception and enhancing perceived social support are beneficial to reduce the level of depression.
The contributions of gender identification and gender ideologies to the purposes of social media use in adolescence
Authors: Manago Adriana M. , Walsh Abigail S. , Barsigian Logan L.
Published: January 2023

Gender differences in adolescent social media use are often documented in the research literature, yet few studies delve into why they occur. Accordingly, we investigated whether gender identification and gender ideologies are associated with five major purposes of social media use in adolescence (emotion and activity bonding with friends, social compensation, appearance validation, and bullying). Participants were 309 cisgender U.S. high school students (Mage = 15.74; 59% girls; 53% white) primarily using Instagram and Snapchat but also TikTok (more popular with girls) and Discord (more popular with boys) in 2019. Girls reported greater use of social media for emotion bonding, appearance validation, and social compensation compared to boys, who reported greater competitive activity bonding. Girls and boys did not differ in their use of social media for bullying. In linear regressions, masculinity ideology predicted purposes associated with girls (appearance validation, social compensation), as well as those associated with boys (competitive activity bonding), regardless of gender. Femininity ideology uniquely predicted emotion bonding and social compensation but only mediated the effect of gender for the latter. Findings illustrate that gender is important for understanding uses and gratifications of social media in adolescence, but traditional masculinity ideology is similar across genders and relates to multiple functions of social media in boys’ and girls’ lives. More work is needed to conceptualize gender beliefs and values in Gen Z, given recent challenges to gender binary ideology and low reliability of the scales in this study, which were developed before social media.
Perceived emotional states mediate willingness to buy from advertising speech
Authors: Nagano Mizuki , Ijima Yusuke , Hiroya Sadao
Published: January 2023

Previous studies have shown that stimulus-organism-response (SOR) theory can well explain the willingness to buy from stores, products, and advertising-related stimuli. However, few studies have investigated advertising speech stimulus that is not influenced by visual design. We examined whether SOR theory using emotional states can explain the willingness to buy from advertising speech stimulus. Participants listened to speech with modified speech features (mean F0, speech rate, and standard deviation of F0) and rated their willingness to buy the advertised products and their perceived emotional states (pleasure, arousal, dominance). We found that emotional states partially mediate the influence of speech features on the willingness to buy. We further analyzed the moderating effects of listeners' attributes and found that listeners' gender and age group moderated the relationship between speech features, emotional states, and willingness to buy. These results indicate that perceived emotional states mediate the willingness to buy from advertising speech.
Relationships among inferiority feelings, fear of negative evaluation, and social anxiety in Chinese junior high school students
Authors: Li Jiajian , Jia Shuxin , Wang Lishen , Zhang Mingming , Chen Shunsen
Published: January 2023

Introduction

This study aimed to explore the relationship between feelings of inferiority and social anxiety in Chinese junior high school students. In addition, it examined the potential mediating effect of fear of negative evaluation in this relationship.

Methods

A survey was administered to a sample of 734 Chinese junior high school students. The Feelings of Inadequacy Scale, Brief Fear of Negative Evaluation Scale, and Social Avoidance Distress Scale were used.

Results

First, there were significant positive correlations between all subscales for the inferiority feelings, social anxiety, and fear of negative evaluation. Furthermore, fear of negative evaluation mediated the predictive effects of four inferiority subscales (i.e., self-esteem, academic ability, appearance, and physical ability) for social anxiety. However, the total score for the sense of inferiority and social confidence subscale lacked this mediating effect.

Conclusion

The inferiority feelings of self-esteem, academic ability, appearance, and physical ability may directly and indirectly predict social anxiety through fear of negative evaluation.
Bibliometric analysis of the effects of mental fatigue on athletic performance from 2001 to 2021
Authors: Chen Xiao-Xin , Ji Zhi-Guang , Wang Yi , Xu Jing , Wang Li-Yan , Wang Hong-Biao
Published: January 2023

Aims

To explore the research hot topics and main contents in the field of the influence of mental fatigue on athletic performance, and to provide new ideas and directions for future research in this field.

Methods

Using CiteSpace and VOSviewer visualization tool software core collection of Web of Science database to TS = (“mental fatigue” OR “mental exertion” OR “cognitive fatigue” OR “Cognitive exertion” OR “mental exhaustion” OR “mental tiredness”) AND (“athletic performance” OR “technical skill*” OR “Skill*” OR “technique” OR “decision making” OR “performance”) AND (“Humans”) searched for the influence of mental fatigue on athletic performance from 2001 to 2021 to conduct visual analysis. Research hot topics were analyzed from the aspects of high-impact countries/regions, institutions, authors, high-frequency keywords, and mutation terms.

Results

A total of 658 publications were identified finally, and there has been an increasing trend in the annual number of publications, with the United States ranking first in the number of publications and influence. Future research will focus on promoting the application of EEG technology as an objective indicator for assessing mental fatigue, exploring effective methods and measures for pharmacological or non-pharmacological interventions against fatigue, and focusing on the effects of mental fatigue on endurance performance, technical skills, and sports-related decision-making.

Conclusion

The results of the present study help us understand the status of the mental fatigue and athletic performance field and its recent developments.
To kill or not to kill: A systematic literature review of high-stakes moral decision-making measures and their psychometric properties
Authors: Ni Benjamin Kai , Burns Bruce D. , Mak Karina K. L. , Lah Suncica , Silva Diego S. , Goldwater Micah B. , Kleitman Sabina
Published: January 2023

Introduction

The present systematic review investigates the psychological tools available for capturing high-stakes decisions involving life-death content and their psychometric properties. Valid measurement of these individual differences will provide crucial information in the personnel selection and training in fields where high-stakes moral issues exist (e.g., military, medicine). To our knowledge, this is the first systematic examination of such instruments.

Methods

Systematic searches of 6 electronic databases were conducted according to the PRISMA guidelines. An appraisal tool evaluated the quality of identified measures. Twenty studies met pre-determined inclusion criteria. Moral decision-making was assessed with either a self-report scale (n= 3) or moral dilemmas (n= 17).

Results

The findings identified two measures, the Defining Issues Test and the Oxford Utilitarianism Scale as psychometrically sound measures of moral decision-making. However, they are unlikely to be considered “gold standard” measures due to their theoretically specific, but limited, scope. Overall, the findings suggest that research in the area has been scattered. There is a lack of consensus on the definition of moral decision-making, and a lack of cross-validation on how different measures of moral decision-making relate to each other. This presents a gap between theory and empirical measurement in moral decision-making. Further work is needed for a unified conceptualization of moral decision-making to pave the way to both theory development and the development of well-validated measurement tools, and this review provides a critical foundation for both.
To what extent is dot comparison an appropriate measure of approximate number system?
Authors: Rodríguez Cristina , Ferreira Roberto A.
Published: January 2023

Introduction:

Number sense has been systematically measured using dot comparison tasks. However, recent studies have reported that performance on dot comparison might be influenced inhibitory control and visual properties of dot arrays. In the present study, we analysed the influence of continuous magnitude, inhibitory control, and numerical ratio on the dot comparison performance of preschool children.

Methods:

Participants were 517 preschool children from 13 different schools in Chile. Children completed a dot comparison and two inhibitory control tasks. Gebuis and Reynvoet method was used to create well-controlled dot arrays for use in the dot comparison task. A logistic mixed effects model was conducted to predict participants’ dot comparison accuracy. Continuous magnitude and ratio were entered as level-1 predictors and inhibitory control as level-2 predictors.

Results:

The results showed that all predictors made a significant contribution to dot comparison accuracy. Furthermore, a significant double interaction (inhibitory control x continuous magnitude) and a triple interaction (inhibitory control x continuous magnitude x ratio) showed that the contribution of inhibitory control skills in dot comparison accuracy depends on the continuous properties of dot arrays and ratio.

Discussion:

These findings suggest that preschool children rely more on continuous magnitudes than numerosity in dot comparison tasks. They also indicate that the greater children’s inhibitory control, the more able they are to respond based on numerosity in fully incongruent trials, particularly when ratio is low (easiest items). Taken together, the above findings support the competing processes account provided that both ANS and inhibitory control skills influence performance on dot comparison tasks.
Dimensions of the health benefits of wellness tourism: A review
Authors: Liao Chenmei , Zuo Yifan , Xu Shaogui , Law Rob , Zhang Mu
Published: January 2023

The benefits of wellness tourism have been recently noted by researchers and industry representatives. This study examined the health dimensions of these benefits posited by a large array of interdisciplinary studies from 2002 up to the present. Open coding was used to conduct an inductive evaluation to classify these health benefits. Results showed four main dimensions, namely, physical fitness, psychological fitness, quality of life (QOL), and environmental health; however, these dimensions need further investigation. Physiological health benefits can also be demonstrated through future experiments, which can further focus on empirical research on the psychological benefits and its overall effect on the QOL. This study contributes to the current literature by providing novel theoretical foundations and subsequently aids practitioners to understand customers better and convey their marketing messages to tourists more effectively.
The use of Messenger for research collaboration: An auto-ethnographic study
Authors: Alonzo Dennis , Oo Cherry Zin
Published: January 2023

The use of social media for the collaboration of academics has been increasing in recent years. However, there are no reported studies on using Messenger as a collaborative platform to write and publish journal articles and apply for research and development grants. We use an auto-ethnography to reflect on our experiences over the last 3 years, using Messenger as our medium for our ongoing collaborative research activities. Our results highlight the benefits and challenges of using social media for this engagement. The capabilities of Messenger, as opposed to traditional correspondence through email, have paved our preference to use this platform. We can engage in dynamic collaboration and focussed discussion with less formal communication conventions through Messenger. In addition, the extra features, including easy phone calls, sending links, resources and screenshots, and using emojis and stickers for more socially cohesive interactions, are valued features of Messenger. We used the activity theory to highlight the interrelationships of factors (i.e., personal, social-emotional, structural, technological, and organisational) contributing to the success of collaborative academic activities, including the successful publication of journal articles and securing research and development grants. The findings of our study significantly contribute to understanding how social media can be effectively used for academic engagement.
Predictors and prevalence of stress, anxiety, depression, and PTSD among university students during the second wave of the COVID-19 pandemic in Turkey
Authors: Aslan Imran , Çınar Orhan
Published: January 2023

This study aimed to find the prevalence of stress, anxiety, depression, and PTSD; differences according to demographic variables; and predictors of mental health problems during the second wave of the coronavirus disease (COVID-19) pandemic in Turkey. Differences in exposure to COVID-19 during the first and second waves of the pandemic among students were compared. A total of 754 students from seven universities in different parts of Turkey participated in the survey between November and December 2020. Perceived Stress Scale (PSS-10), Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire (PHQ-9), Checklist-Civilian Version (PCL-C) scale measuring posttraumatic stress disorder (PTSD), and Satisfaction with Life Scale (SWLS) were used to measure the mental well-being of students. Descriptive statistics, one-way ANOVA, correlations, and multinomial logistic regression methods were used to analyze the data. The prevalence of high stress, high generalized anxiety (GAD-7 ≥ 10), high depression symptoms (PHQ-9 ≥ 10), and high PTSD in the total sample were 84.2, 36.2, 55.0, and 61.2%, respectively. High perceived stress, moderate generalized anxiety disorder, mild depression symptoms, high severity PTSD, and moderate satisfaction were found among students in Turkey. Religiosity and spirituality have significant negative correlations with anxiety, depression, and PTSD. Religiosity level, gender, relationship status, year of study, physical activity, symptoms of coronavirus, death of a close relative, job loss, and economic status are significant parameters for predicting psychological problems of students in Turkey.
The role of diverse leadership styles in teaching to sustain academic excellence at secondary level
Authors: Maqbool Samra , Zafeer Hafiz Muhammad Ihsan , Zeng Pingfei , Mohammad Tamara , Khassawneh Osama , Wu Ling
Published: January 2023

Educational leadership is a multifaceted area of study. Unquestionably, leadership is the most deliberate field within the social sciences. Still, administrators have evaded the notions of leadership concept like a haunting tune. This study has focused particularly on the significance of varied leadership styles in teaching to sustain academic excellence at the secondary school level. The quantitative research method was used. Data was collected through the scale of diverse leadership styles (strategic, cultural, instructional leaderships and sustaining academic excellence) from 103 secondary schools in Punjab, Pakistan. The sample consisted of 540 teachers who were enacting as teachers presently. Based on research objectives and questions, two hypotheses were formed and tested using mean analysis to determine the average ranking of leadership styles. Pearson correlation to know the statistically significant relationship between each leadership styles, and overall scales with sustaining academic excellence. The results revealed that most teachers give preference strategic Leadership, then instructional leadership, and finally cultural leadership in their teaching to sustain academic excellence. Moreover, the findings also indicated that a statistically strong positive relationship among diverse leadership styles in teaching and sustaining academic excellence with the value (r = 0.752). Based on the findings, it has been concluded that when teachers increase their effort in the use of strategic, instructional, and cultural leadership styles, academic excellence may also sustain and improve.
Exploring consumer perceived risk and purchase intention of water-saving appliances: A moderated dual-mediation model
Authors: Wang Teng , Tian Ming
Published: January 2023

With the blooming of the socio-economy in China, urban water consumption continues rising, and the promotion of water-saving appliances has become one of the priorities of water saving efforts. Based on the perceived risk theory, this research constructs a moderated mediation model to explore the mechanisms that explain and affect consumers’ willingness to purchase water-saving appliances. The study finds that consumers’ perceived risk of buying water-saving appliances is mainly functional, economic, and psychological risks. Perceived risk will reduce consumers’ quality trust and green trust in water-saving appliances, and indirectly influences consumers’ willingness to buy through quality and green trust. In addition, we find that consumer knowledge of water-saving appliances can weaken the negative impact of perceived risk on quality trust and green trust and the indirect inhibitory effect on purchase intentions. In final, we provide policy recommendations to guide consumers to purchase water-saving appliances and promote the popularization of water-saving appliances.