bluuebunny/crossref_metadata_2025 huggingface dataset:
ZC3H4 Regulates Infiltrating Monocytes, Attenuating Pulmonary Fibrosis through IL-10
Authors: Liu Yaping , Zhang Xinxin , Wang Jing , Yang Fuhuang , Huang Jie , Chen Mengling , Wang Sha , Zhang Wei , Li Caolong , Chao Jie
Published: January 2022

Silicosis is a pulmonary fibrosis-associated disease caused by the inhalation of large amounts of free silicon dioxide (SiO2) that mainly manifests as early inflammation and late pulmonary fibrosis. As macrophage precursors, monocytes accumulate in the lung during early inflammation, but their role in the development of silicosis is unclear. Single cell sequencing, western blotting, quantitative real-time PCR, ELISA and cell functional experiments were used to explore the specific effects of monocytes on fibroblasts. The CRISPR/Cas9 system was used to specifically knock down ZC3H4 and was combined with pharmacological methods to explore the mechanism by which ZC3H4 affects chemokine and cytokine secretion. The results indicated that 1) SiO2 induced an infiltrating phenotype in monocytes; 2) infiltrating monocytes inhibited the activation, viability and migration of fibroblasts by regulating IL-10 but not IL-8; and 3) SiO2 downregulated IL-10 via ZC3H4-induced autophagy. This study revealed that ZC3H4 regulated the secretion function of monocytes, which, in turn, inhibited fibroblast function in early inflammation through autophagy signaling, thereby reducing pulmonary fibrosis. These findings provide a new idea for the clinical treatment of silicosis.
Solid-phase Synthesis of Non-metal (S, N) -doped Tin Oxide Nanopowders at Room Temperature and Its Photodegradation Properties for Wastewater of Biomass Treatment
Authors: Shao-you Liu , Qian Wang , Li-hui Ou , Hong-li Du , You Long , Wei-jun Zhen
Published: January 2022

The samples such as tin oxide(SnO2), sulfur-doped tin oxide(S-SnO2), nitrogen-doped tin oxide(N-SnO2), and sulfur, nitrogen-codoped tin oxide (S+N-SnO2) nanopowder catalysts were prepared by a solid-state reaction at room temperature, using the sodium p-toluene sulfonate (STS) surfactant as template. And the microstructure of the materials was characterized by XRD, TEM, XPS, FTIR and UV-Vis. Meanwhile, the photocatalytic degradation mechanism and its performances of these samples used for the rice straw powder treatment wastewater (RSPTW) under UV-light irradiation were discussed, as well as its COD and NH3-N value were tested. It is shown that the large gap of the reaction energy between intramolecular dehydration(Er=2.81eV) and intermolecular dehydration(Er=5.77eV) of tin hydroxide causes the presence of amorphous SnO2 and metastable tin hydroxide at low calcination temperature of 450oC. S as S4+ and N as N3+ enters into the SnO2 (110) crystal plane and generates the impurity level, reducing the energy band gap width (△Eg) from the SnO2-blank of 3.6eV to S+N-SnO2-STS of 2.22eV. After UV-light irradiation for 8 h, the photocatalytic degradation rate of S+N-SnO2-STS sample for the RSPTW reaches 98.9% under the optimization control conditions, exhibiting the excellent capability to degrade the biomass wastewater. The changes of energy gap width may major be derived from the hydroxyl radicals (•OH) and superoxide radicals (•O2-) produced by the rich hydroxyl on the S+N-SnO2-STS photocatalyst surface, and regulatory effect of surfactant. The photodegraded RSPTW complies with Chinese National Level II Standards for Integrated Sewage Discharge.
Amino acid metabolism and prognostic markers in ischemic stroke patients
Authors: zhang chenxi , wang lijuan , qiu nan , shi yijun , ding yaowei , li guoge , zheng guanghui , zhang guojun
Published: January 2022

Ischemic stroke continues to be a serious public health problem worldwide, we compared the amino acid profiles of convalescent patients with ischemic stroke with healthy subjects by High Performance Liquid Chromatography (HPLC), 48 convalescent patients with ischemic stroke and 48 healthy controls were recruited, finding that the levels of Phosphoserine(P-Ser), Glutamic Acid(Glu), Isoleucine(Ile), Leucine(Leu), Phenylalanine(Phe), Arginine(Arg), Proline(Pro) in stroke patients increased significantly, and the levels of Taurine(Tau), Cystine(Cys), Methionine(Met), b-Alanine(b-Ala), Histidine(His) lowered in patients compared to controls (P<0.05). Furthermore, it was particularly important to find indicators that could judge the prognosis of patients, the Tau/Glu level could be used as a potential prognosis marker and considering convalescent stroke patients have a good prognosis when the ratio > 0.79 in our study.
Signal Processing of Internet of Vehicles Based on Intelligent Interference
Authors: Wu Xiangyu , Hou Changbo , Deng Zhian , Fang Chenyu , Liu Guowei
Published: January 2022

With the rapid development of in-vehicle electronic technology and artificial intelligence, Internet of Vehicles (IoV) technology, as an effective integration of the two, greatly reduces the probability of road traffic accidents. However, the current IoV system is not perfect for the control process of abnormal vehicles. Therefore, in order to strengthen the management and control of abnormal vehicles in the IoV, it is extremely necessary to propose a method for interfering with IoV signals. Among the current popular intelligent interference methods, most of them rely on the prior knowledge of the signal to deduce the best interference waveform. However, These methods rely too much on prior knowledge to be practically applicable. Therefore, in view of the shortcomings of the current communication interference technology, this study proposes an interference waveform generation technology based on convolutional autoencoders. The convolutional autoencoder was used to change the features on the fully connected layer to generate an interference waveform that is very similar to the received signal waveform, and the interference waveform is sent to the receiver to realize the control of the IoV signal. The simulation results show that the interference waveform generation technology proposed in this study can make the bit error rate (BER) reach 38.4\% within the signal-to-interference ratio (SIR) from -10dB to -15dB.
Swine Lagoon Compost: Analysis as Transplant Substrate for ‘Traviata’ Eggplant, ‘Clemson Spineless’ Okra, and ‘Moneymaker’ Tomato
Authors: Noah Abbey C. , Kraus Helen T. , Herring Paige L.
Published: January 2022

Composted swine (Sus domesticus) lagoon solids may provide a nutrient rich alternative to peatmoss (Sphagnum sp.) in a transplant substrate while dispersing the concentrated nutrients of this waste product in a cost effective, environmentally conscientious manner. The objective of this study was to evaluate the physical and chemical characteristics of swine lagoon solids composted with peanut (Arachis hypogaea) hulls and evaluate the utility of this substrate to support growth of vegetable transplants. Swine lagoon solids were composted in an in-vessel compost reactor with peanut hulls 15:85 v/v producing a transplant substrate, swine lagoon compost (SLC). A greenhouse study was conducted with three vegetable species: ‘Moneymaker’ tomato (Solanum lycopersicum), ‘Traviata’ eggplant (Solanum melongena), and ‘Clemson Spineless’ okra (Abelmoschus esculentus) grown in SLC, an organic potting mix (OM), and a peatmoss-based substrate (PEAT). ‘Traviata’ eggplant, ‘Clemson Spineless’ okra, and ‘Moneymaker’ tomato transplants produced in SLC substrate were significantly greater in height and dry weight than those produced in either the OM or PEAT. Based on these findings SLC can provide both the physical and chemical requirements needed for vegetable transplant production without additional amendments or fertilizers.
Influence of initial platinum-based chemotherapy on levels of He-4 protein and VEGF-A in primary tumors and metastases from ovarian cancer
Authors: Frantsiyants E. M. , Moiseenko T. I. , Yakubova D. Yu. , Cheryarina N. D. , Menshenina A. P. , Verenikina E. V. , Adamyan M. L.
Published: January 2022

Introduction. Recently, the he-4 protein has received great attention due to its diagnostic and prognostic abilities in epithelial ovarian cancer. In addition to its diagnostic value, this protein is involved in the pathogenesis of ovarian cancer. Another significant pathogenetic factor is the vascular endothelial growth factor (vegf) which plays a key role in neoangiogenesis. The purpose of the study focused on the analysis of he-4 and vegf-a levels in tissues of ovarian cancer, in healthy contralateral ovaries and in common metastatic tumors in the omentum and peritoneum to determine the place and role of these tumor markers at the stages of carcinogenesis. Material and methods. The study was performed using the abovementioned tissues of 93 patients with t2-3nхm0-1 ovarian cancer. 51 patients underwent surgery followed by chemotherapy. 42 patients received initial neoadjuvant chemotherapy followed by surgery and adjuvant cytostatic therapy. Tissue samples from 17 patients with benign diseases were used as the control for determining the reference values for he-4 and vegf-a. A comparison was made between groups of patients with and without neoadjuvant therapy, as well as in groups of patients depending on the effectiveness of cytostatic treatment. Results. The levels of he-4 in primary and metastatic tissues affected and not affected by cancer were initially elevated in patients with ovarian cancer. The chemotherapy effectiveness directly correlated with the level of he-4 reduction, which did not change or increased in tumors resistant to medical treatment. The level of vegf-a significantly differed in cancer and non-cancer tissues, which indicated its significant pathogenetic effect not “before”, but at the stages of morphological malignization. The dynamics of vegf-a decrease in this study did not depend on the chemotherapy effect. Conclusion. The he-4 marker is a pathognomonic factor in the development of ovarian cancer, preceding morphological signs of malignancy and reflecting the effectiveness of chemotherapy, while vegf-a is most likely a consequence of the cancer development.
Rejuvenation in rural Ireland in response to the COVID-19 induced urban-to-rural migration phenomenon
Authors: Sen Shreya
Published: January 2022

The aim of this paper is to discuss the paradigm shift in residential choices induced by the COVID-19 pandemic in Europe. Firstly, the resilience of the rural regions belonging to the Northern Periphery and Arctic Program will be explored—the challenges brought about by COVID-19 within their tourism sectors, and the opportunities for rural revival generated by the current shifts in workplace mobility. The paper will then delve deeper into the case study of Ireland. The pre-existing issue of Ireland’s one-off housing and suburban sprawl will be explored, and the extent to which the regional plan “Our Rural Future” will tackle these issues by optimizing building density and dwelling typology in the post-COVID-19 era.
Towards a Comprehensive Climate Adaptation Framework for India’s Port Infrastructure and Operations: Lessons from Global Best Practices
Authors: Bajaj Pushp , Youdon Chime
Published: January 2022

The ever-growing impacts of climate change such as extreme heat, more frequent heavy precipitation events, intensifying tropical revolving storms, and sea level rise continue to pose major threats to India’s critical maritime infrastructure. As the country moves towards its ambition of becoming a leading Blue Economy of the world, a wide range of initiatives have been taken by the central and state governments to expand the maritime sector with a specific focus on the transport sector. However, there is little emphasis being paid on protecting the existing and planned seaport infrastructure against the deleterious impacts of climate change. None of the major ports in India have a dedicated climate action strategy and climate adaptation finds no mention in the policy documents pertaining to the maritime transport sector. In this context, this paper aims to highlight the need for a comprehensive, holistic and dynamic climate change adaptation strategy for India’s port infrastructure including support infrastructure and supply chains. The adaptation strategy, at the individual ports’ level and the national level, must be preceded by rigorous risk assessment studies to identify and prioritise the major challenges arising from climate change at the local level. The paper draws upon international best practices in climate risk assessments and adaptation measures to provide a way forward for Indian ports
Evaluation of classification and decision trees in predicting daily precipitation occurrences
Authors: Samadianfard S. , Mikaeili F. , Prasad R.
Published: January 2022

Due to the heterogeneous distribution of precipitation, predicting its occurrence is one of the primary and basic strategies to prevent possible disasters and their damages. Hence, this study aims at evaluating the capabilities of Logistic Model Tree (LMT), J48, Random Forest (RF), and PART classification algorithms in precipitation forecasts at Pars Abad station using previous 1–4 days data of meteorological variables. So, five scenarios were considered based on the cross-correlation function and partial autocorrelation function for validation of the studied methods in the period of 2004–2019. In general, by examining the Kappa, root mean squared error (RMSE), mean absolute error (MAE) indicators, scenario number 1 using the input parameters of 1-day lag was determined as the most appropriate scenario to predict daily precipitation. Also, the obtained results showed that the PART had better performance with more than 80% accuracy in precipitation forecasting. Moreover, the most accurate performance of PART was scenario 1 with Kappa = 0.2007, RMSE = 0.3879 and MAE = 0.2856. The conclusive results indicated that by implementing classification algorithms and decision trees and using meteorological data of the previous days, daily precipitation could be predicted accurately.
Investigating the source apportionment of heavy metals in soil surrounding reservoir using partial least-squares regression model
Authors: Huang Xu-dong , Han Pei-pei , Ma Mei-jing , Cao Qiong , Li Wei-zhuo , Wan Fang , Zhang Xiao-li , Chai Qi-hui , Zhong Ling , Li Bao-jian
Published: January 2022

The assessment of heavy metal pollution is crucial for water conservation. This study determined the contents of heavy metals (Cd, Cr, Cu, Ni, Pb, Zn and As) from 39 soil samples surrounding a reservoir, and analyzed the corresponding source and enrichment using enrichment factors and partial least-squares regression. The concentration of Cr (54.06 mg/kg) was lower than the background value of the reservoir area, while the Cd concentration was higher (0.96 mg/kg). Moreover, Cd, Cr, Ni, Pb, Zn and As concentrations in the south exceeded those of the northeast in the Nanwan lake reservoir (NLR). Cd and As were the dominant contaminated elements in the NLR. The Cd enrichment factor value was 11.25, areas with moderate and higher levels of pollution of Cd occupied 89.0% of the total area, while As occupied 18.4%. The dominant sources of Zn, Ni, Cu, Pb and Cr were identified as natural inputs, those of As were agricultural production activities, and those of Cd were industrial production activities. This study provides insight into the heavy metal pollution and key factors of land-use types in watersheds with tea trees as the dominant vegetation cover, and aids in the planning of water pollution prevention and ecological protection.
Aerogenic pollutants as risk factors causing development of cardio-metabolic pathology (Review)
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Nosov A.E. , Baydina A.S. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Ustinova O.Yu. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation,   Perm State National Research University, 15 Bukireva Str., Perm, 614990, Russian Federation
Published: January 2022

Ambient air pollution causes approximately 3.3 million untimely deaths annually (2.1 deaths due to ischemic heart disease and 1.1 million deaths due to stroke). Mortality caused by ambient air pollution is higher than mortality due to such traditional risk factors as smoking, obesity, and elevated dextrose contents in blood. Relative risk of mortality amounts to 1.26 (95 % CI 1.08–1.47) in cities with the highest air pollution against those where air pollution is the lowest. Occupational exposure to various chemical air pollutants can cause more than 1 million untimely deaths all over the world but its contribution to prevalence of cardiovascular diseases has not been determined sufficiently. Aerogenic pollutants are quite variable in their chemical structure and include both particulate matter (PM for short) and gaseous matter. The American Heart Association and the European Society of Cardiology consider PM2.5 to be a risk factor causing cardiovascular diseases. This analytical review presents data on effects produced by aerogenic pollutants on development of cardio-metabolic pathology and population mortality due to vascular and metabolic diseases (arterial hypertension, atherosclerosis and ischemic heart disease, heart rhythm disturbances, and type 2 diabetes mellitus). There are also data on mechanisms of pathogenetic influence exerted by aerogenic pollutants on development of such diseases including generation of anti-inflammatory and oxidative mediators and their release into blood flow; developing imbalance in the autonomic nervous system with prevailing activity of the sympathetic nervous system and disrupted heart rate variability; direct introduction of aerogenic pollutants from the lungs into blood flow with developing direct toxic effects. We have also analyzed literature data on protective effects produced by reduction in ambient air pollution on prevalence of cardiovascular pathology.
Factors and directions of revision of the French social paradigm
Authors: Ivanova S. V. , Matytsyn A. V.
Published: January 2022

Historically, France is home to a number of concepts and practices for the creation of the welfare state (État providence). The state social policy is organically woven into the economic mechanism of this country and, it seemed, is its integral part. The purpose of the article is to identify the main directions of the revision of the social French paradigm. The generalization of the bibliography, historical and statistical analysis made it possible to identify a number of factors of such a revision, including the processes of transnationalization of French business, the scaling of trade, and the crisis of the post-industrial phase of global capitalism. The conclusion is substantiated that the shocks of the 2019 pandemic at the beginning of 2021 accelerated the evolution of French social policy in favor of the communitarian level due to the limited opportunities for social reforms at the country level. The antithesis of the initiatives of Emmanuel Macron is the growth of nationalist sentiments and ideas of Charles de Gaulle against the background of the crisis of convergence of the economies of the member countries.
MicroRNAs in Helminth Parasites: A Systematic Review
Authors: Alizadeh Zahra , Mahami-Oskouei Mahmoud , Spotin Adel , Ahmadpour Ehsan , Cai Pengfei , Sandoghchian Shotorbani Siamak , Pashazadeh Fariba , Ansari Fereshteh , Mohammadi Hamed
Published: January 2022

Background:

MicroRNAs (miRNAs) are about 22-nucleotide, small, noncoding
RNAs that control gene expression post-transcriptionally. Helminth parasites
usually express a unique repertoire of genes, including miRNAs, across different
developmental stages with subtle regulatory mechanisms.

Objective:

There is a necessity to investigate the involvement of miRNAs in the
development of parasites, host-parasite interaction, immune evasion and their abilities to
govern infection in hosts. MiRNAs present in helminth parasites have been summarized
in the current systematic review (SR).

Methods:

Electronic databases, including PubMed, Scopus, ProQuest, Embase, and
Google Scholar search engine, were searched to identify helminth miRNA studies
published from February 1993 till December 2019. Only the published articles in English
were included in the study.

Results:

A total of 1769 articles were preliminarily recorded. Following the strict inclusion
and exclusion criteria, 105 studies were included in this SR. Most of these studies
focused on the identification of miRNAs in helminth parasites and/or probing of
differentially expressed host miRNA profiles in specific relevant tissues, while 12 studies
aimed to detect parasite-derived miRNAs in host circulating system and 15 studies
characterized extracellular vesicles (EV)-derived miRNAs secreted by parasites.

Conclusion:

In the current SR, information regarding all miRNAs expressed in helminth
parasites has been comprehensively provided and the utility of helminth parasitesderived
miRNAs in diagnosis and control of parasitic infections has been discussed.
Furthermore, functional studies on helminth-derived miRNAs have also been presented.
New Association Between Diabetes Mellitus and Pancreatic Cancer
Authors: Bakhtiyari Salar , Rezaei Monireh , Shams Zinat , Rasouli Bahareh Sadat , Amirfard Katayoun Dadeh , Sadrabadi Mohadeseh Soleymani , Gheysarzadeh Ali , Haghani Karimeh
Published: January 2022

Background:

Diabetes mellitus is a global issue that has affected the lives of many people
all over the world. This disorder, which is also called the mother of all diseases, possesses high
pathogenicity and results in the emergence of many disorders. One of the known correlated diseases
is pancreatic cancer which can be accompanied by diabetes mellitus. Therefore, finding the association
between these diseases and common genes is urgent.

Objective:

In this study, in order to survey the relationship between diabetes mellitus and pancreatic
cancer, the common genes of these disorders were analyzed by bioinformatics tools.

Methods:

For this purpose, we screened 17 shared genes from microarray data downloaded from
the Gene Expression Omnibus (GEO) database. In addition, the relationship between identified
genes was constructed by STRING and DAVID tools.

Results:

In total, 112 genes were identified to be differentially expressed. Among these, 17 genes
were found to be common, including two genes that were down-regulated and others that were upregulated.
Other analyses showed that most of the genes were enriched in Vibrio cholera infection
and the mTOR signaling pathway. The biological processes of such genes included oxygen and gas
transport, phagosome acidification, and GTPase activity.

Conclusion:

In this study, 17 common genes that had not previously been considered in diabetes
and pancreatic cancer were screened, which can be further considered for clinical approaches and
in vitro studies.
Biomedical Applications of Carbohydrate-based Polyurethane: From Biosynthesis to
Degradation
Authors: Batool Jahan Ara , Rehman Kanwal , Qader Abdul , Akash Muhammad Sajid Hamid
Published: January 2022

The foremost common natural polymers are carbohydrate-based polymers or polysaccharides, having
a long chain of monosaccharide or disaccharide units linked together via glycosidic linkage to form a complex
structure. There are several uses of carbohydrate-based polymers in the biomedical sector due to their attractive
features, including less toxicity, biocompatibility, biodegradability, high reactivity, availability, and relative inexpensiveness.
The aim of our study was to explore the synthetic approaches for the preparation of numerous
carbohydrate-based polyurethanes (PUs) and their wide range of pharmaceutical and biomedical applications.
The data summarized in this study show that the addition of carbohydrates in the structural skeleton of PUs not
only improves their suitability but also affects their applicability for use in biological applications. Carbohydrate-
based units are incorporated into the PUs, which is the most convenient method for the synthesis of novel
biocompatible and biodegradable carbohydrate-based PUs for use in various biomedical applications.
Changes in Physical and Mental Functions in Patients with Cardiovascular
Disease During the First Two Waves of COVID-19 in Japan
Authors: Izawa Kazuhiro P. , Ishihara Kodai , Noto Shinichi , Shimizu Ikki
Published: January 2022

Background and Objectives:

The goal of this study was to determine whether changes in
life-space mobility and quality of life (QoL) recovered in patients with cardiovascular disease
(CVD) during the first two waves of the pandemic of Coronavirus disease 2019 (COVID-19) in Japan.

Methods:

We performed a follow-up survey in 20 CVD patients using the Life-Space Assessment
(LSA) scale and the five-level EuroQoL five-dimensional questionnaire (EQ-5D-5L), Japanese version,
at three time points: January-March 2020 (before the first wave of the COVID-19 pandemic),
July 2020 (following the first wave of the pandemic), and November 2020 (following the second
wave of the pandemic).

Results:

The LSA score in November 2020 (median [interquartile range], 90 [83.5-100] points) did
not recover from the July 2020 score (83 [76.5-93] points). However, the EQ-5D-5L QoL score in
November 2020 (0.89 [0.82-1]) had improved from that in July 2020 (0.80 [0.71-0.87]).

Conclusions:

The QoL of CVD patients might have been more affected by psychological factors
rather than physical factors during the first two waves of the COVID-19 pandemic in Japan.
Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3-
yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
Authors: Dung Do Thi Mai , Park Eun Jae , Anh Duong Tien , Hai Pham-The , Bao Le Quang , Ji A Young , Kang Jong Soon , Tung Truong Thanh , Han Sang-Bae , Nam Nguyen-Hai
Published: January 2022

Background:

Herein, we have designed and synthesized a series of the novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides (5) as potent small molecules activating procaspase-3. The compounds were designed by the amalgamation of structural features of PAC-1 (the first procaspase-3 activator) and oncrasin-1, one potential anticancer agent.

Methods:

The target acetohydrazides (5a-m) were prepared via the Niementowski condensation of anthranilic acid (1a) or 5-substituted-2-aminobenzoic acid (1b-m) and formamide. The compound libraries were evaluated for their cytotoxicity, caspase-3 activation, cell cycle analysis, and apoptosis. In addition, computational chemistry is also performed.

Results:

A biological evaluation revealed that all thirteen compounds designed and synthesized showed strong cytotoxicity against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer) with eight compounds (5a, 5c-i, 5k), which were clearly more potent than both PAC-1 and oncrasin-1. In this series, four compounds including 5c, 5e, 5f, and 5h, were the most potent members with approximately 4- to 5-fold stronger than the reference compounds PAC-1 and oncrasin-1 in terms of IC50. In comparison to 5-FU, these compounds were even 18- to 29-fold more potent in terms of cytotoxicity in three human cell lines tested. In the caspase activation assay, the caspase activity was activated to 285% by compound 5e in comparison to PAC-1, the first procaspase activating compound, which was used as a control. Our docking simulation revealed that compound 5e was a potent allosteric inhibitor of procaspase-3 through chelation of inhibitory zinc ion. Physicochemical and ADMET calculations for 5e provided useful information of its suitable absorption profile and some toxicological effects that need further optimization to be developed as a promising anticancer agent.

Conclusion:

Compound 5e has emerged as a potential hit for further design and development of caspases activators and anticancer agents.
In Vitro Cytotoxicity and Apoptosis Inducing Evaluation of Novel Halogenated Isatin
Derivatives
Authors: Adibi Hadi , Beyhaghi Ehsan , Hayati Sonya , Hosseinzadeh Leila , Amin Niloufar
Published: January 2022

Background:

Isatin (1H-indole-2,3-dione) and its derivatives have been utilized in a variety of biological
activities. Anticancer compounds were the most extensively highlighted and explored among the range of beneficial
properties.

Objective:

Herein, we report the targeting effect of halogenated isatin derivatives on cancer cell mitochondria and their
antiproliferative mechanism.

Method:

A series of novel 5-halo-Isatin derivatives consisting of the 5-Amino-1,3,4-thiadiazole-2-thiol scaffold were
synthesized and easily conducted in good yields through a condensation reaction between keto groups of Isatin and
primary amine under alcoholic conditions, followed by S-benzylation. The compounds were fully characterized using
spectroscopic methods such as 1H-NMR, FTIR, mass spectroscopy and then tested in vitro towards three cancer cell
lines HT-29 (colon cancer), MCF-7 (breast cancer), and SKNMC (neuroblastoma). Apoptosis induction was investigated
through assessment of caspase 3 and mitochondrial membrane potential.

Results:

The most potent compounds of 5b, 5r (IC50 = 18,13 μM), and 5n (IC50 = 20,17 μM) were found to show
strong anticancer activity, especially for MCF7 cells. Further anticancer mechanism studies indicated that 5b and 5r
induced apoptosis through the intrinsic mitochondrial pathway.

Conclusion:

This research demonstrated that 5b and 5r have an anticancer property via the modulation of oxidative
stress-mediated mitochondrial apoptosis and immune response, which deserves further studies on their clinical applications.
O Malta Study Center @ Hill Museum & Manuscript Library : percurso e convergências
Authors: Garradas Cláudia
Published: January 2022

Created in 1973 with the aim of preserving and disseminating the cultural material of the Order of Malta and the history of the island of Malta, ruled by that religious and military Order for over 200 years, the Malta Study Center at the Hill Museum & Manuscript Library, has since developed projects of preservation and cataloguing of manuscripts, rare books and art objects that goes beyond the borders of this small island at the heart of the Mediterranean. The initially local microfilming project of rare documents at risk quickly became a project without term and with international visibility. The arrival of the digital imposed the need of a collaboration with different professionals and local institutions to create a methodology for cataloguing and finding aids, using standards, control of vocabulary and terminology and the creation of a database of authority files
Avaliação diagnóstica de serviços educativos : alguns resultados do caso da Rede de Museus de Vila Nova de Famalicão
Authors: Palma Louise
Published: January 2022

This paper showcases the key results from the internship report, defended at the conclusion of the master’s degree in Museology, oriented by Alice Semedo and co-oriented by Liliana Aguiar. The objective was to apply a diagnostic evaluation approach to map the activities proposed by the educational programmes of Museum Network of Vila Nova de Famalicão. For this, a simultaneous mixed methods design with traces of an ethnographic design was used. The data was collected through an online survey and a diagnostic form, with the objective of tracing a profile of employees, defining a relationship between the educational programmes of museums and their teams, and mapping the educational activities planned for 2019. The data analysis shows that, when applied in the context of the educational programming, the evaluation presents itself as a useful and relevant method to understand practices and as a starting point for deeper changes.
Experience of distance learning during COVID-19 pandemic among undergraduate nursing students
Authors:   Faculty of Nursing, King Abdulaziz University, Jeddah, Saudi Arabia, et al. Alghamdi
Published: January 2022

COVID-19 Pandemic has a huge influence on the learning process worldwide. To maintain student academic progress, learning activities were converted to distance learning to control the further spread of the COVID-19 virus. During this period several studies around the world were conducted to assess the effectiveness of distance learning. The results of these studies showed different perspectives, some of the students preferred e-learning while other preferred traditional methods. The aim of this study was to assess the experience of undergraduate nursing students who used distance learning during the COVID-19 pandemic. A quantitative, cross-sectional design was used to conduct the study. A convenient sampling approach was used to collect the data electronically via self-reported questionnaires. The study included 328 participants. The average score of the effectiveness domain was (2.58±0.68, medium level), and the satisfaction domain was (2.56±0.54, medium level). The results indicate that technical issues were the most significant barrier (75.6%) to distance learning, followed by physical problems, and decreased access to technological devices. Savings in transportation costs (74.1%), savings in time (71.6%), and the opportunity to review recorded lectures (67.4%) were the benefits of distance learning reported by nursing students during the COVID-19 pandemic. Most of the nursing students reported a positive preference for distance learning. Technical issues were the most significant barrier while decreased transportation costs were the most significant facilitator. These findings were consistent with other studies from different settings. Further research is needed to build upon these findings.
Narrative language development of Persian-English bilingual children attending an immersion preschool
Authors: Payesteh Bita , Finestack Lizbeth H.
Published: January 2022

Purpose: This study aimed to provide a better understanding of the language development of bilingual children who attend a Persian immersion preschool in the United States, with a specific focus on their microstructural language skills derived from a story retell task.Methods: Participants included two groups of preschoolers: 14 Persian-English bilingual children who attended a Persian immersion preschool (2- through 5-years of age) and 16 monolingual English-speaking children who attended an English-only preschool (3- through 5-years of age). Participants completed a story retell task, and their parents completed a questionnaire regarding their child’s language environment.Results: Analyses revealed that Persian-English bilingual children produced narratives that are comparable to their same-aged, English monolingual peers with regard to measures of microstructure. Furthermore, mean length of utterance in morphemes was significantly associated with parental language input, positively with Persian input, and negatively with English input.Conclusions: Findings demonstrate that Persian-English bilingual children who attend a Persian immersion preschool develop English to a level comparable to same-age English monolingual peers based on language produced during a story retell task.
Ultra-fast Consolidator Machine Development – Individualized Mass Production of Thermoplastic Tailored Blanks based on Laser-assisted Tape Placement with in-situ Consolidation
Authors: Emonts Michael , Fischer Kai , Peitz Alexander , Weiler Thomas
Published: January 2022

The new UItra-Fast Consolidator Machine development offers both high flexibility and mass production of tailored thermoplastic laminates with reduced scrap. The machine system can be configurated to achieve fully consolidated multi-layer laminates with different fiber directions and minimized scrap (thermoplastic tailored blanks) produced in cycle times below 5 seconds. This individualized mass production is accomplished by a combination of laser-assisted tape placement with in-situ consolidation and a piece-flow principle, which is state of the art in the printing industry but has not been used in such a way within composite production. The achievable productivity is enhanced to more than 500 kg/hour by this piece-flow principle with carriers moved through multiple application stations which are equipped with multiple tape placement applicators. The new machine is scalable: multiple application stations can be added, e.g. for each layer one station for mass production or for each fiber direction one station with a carrier-conveyor carousel: here the carriers are moved multiple times through the application stations.

This innovative machine system is a result of an 18-months AZL Joint Partner Project, conducted in 2017-2018 by the research partners AZL Aachen and Fraunhofer IPT Aachen, in cooperation with 12 industrial partner companies including Conbility, Covestro, Engel, Evonik, Fagor Arrasate, Faurecia SE, Laserline, Mitsui Chemicals, Mubea Carbo Tech, Philips Photonics, SSDT and Toyota (in alphabetical order). The system won the international JEC Innovation AWARD 2019 in the category “Industry & Equipment”.
The Dynamics of Immunological Indicants on the Background of Therapy Using Probiotics and Psyllium in Patients with Chronic Pancreatitis after Cholecystectomy
Authors: RUSIN V.I. , SIRCHAK YE.S. , KURCHAK N.YU.
Published: January 2022

The results of complex examination and treatment of 64 patients with chronic pancreatitis after cholecystectomy are given. It is ascertained, that complex therapy with the use of probiotics and psyllium in patients with chronic pancreatitis after cholecystectomy has marked positive effect on dysbiotic changes and immunity indicants (IgA, IgG, IgM, C3, C4) compared to monotherapy with corresponding medications.
Обоснование выбора метода операции в хирургическом лечении осложненных форм хронического панкреатита
Authors: Ratchik V.M. , Gaydar Yu.A.
Published: January 2022

В клинике института за период 2010–2012 гг. оперировано 43 пациента по поводу осложненных форм хронического панкреатита. На основании данных компьютерной томографии и эндоскопической ретроградной панкреатохолангиографии выделялись значимые для выбора метода операции варианты патологии поджелудочной железы. Оценка интраоперационных биопсий показала, что основным проявлением хронического панкреатита во всех случаях выступал выраженный фиброз ткани железы. При этом, если у больных с III степенью фиброза фиброзная ткань составляла 68,2–76,4 % площади поджелудочной железы, а экзокринная — 16,2–24,8 %, у больных с IV степенью фиброза соответственно 79,5–95,5 и 2,3–10,8 %. Выделены показания для выполнения органосохраняющих резекционных, резекционно-дренирующих вмешательств и изолированных, дренирующих протоковую систему поджелудочной железы операций. Удельный вес комбинированных резекционно-дренирующих вмешательств с сохранением двенадцатиперстной кишки составил 30,2 %, общая летальность — 2,3 %, количество послеоперационных койко-дней — (9,1 ± 0,8).
Особливості перебігу та можливості корекції кишкового дисбіозу у хворих на ішемічну хворобу серця
Authors: Arkhiy E.Y. , Derbak Ya.S. , Derbak S.E.
Published: January 2022

У статті наведено результати обстеження та лікування 107 хворих на ішемічну хворобу серця у поєднанні із дисбіозом кишечника. Показано, що домінуючим симптомом кишкового дисбіозу у хворих на ішемічну хворобу серця є запор. Включення до стандартних схем терапії ішемічної хвороби серця засобів корекції мікробіоценозу кишечника сприяє зменшенню вираженості не тільки дисбіотичних змін, але й клінічних симптомів основного захворювання.
Жорсткість печінки за даними зсувнохвильової еластографії у хворих на цукровий діабет типу 2 з неалкогольною жировою хворобою печінки залежно від активності процесу НАЖХП
Authors: Dynnyk O.B. , Mykhalchishin G.P. , Kobyliak N.M. , Bodnar P.M.
Published: January 2022

Зсувнохвильова еластографія є одним із найбільш перспективних неінвазивних методів діагностики фіброзу та стеатозу при хронічних дифузних захворюваннях печінки, що можуть використовуватись як альтернатива біопсії. З огляду на її широке впровадження в клінічну практику групами вчених з усього світу все більше уваги приділяється вивченню факторів, які можуть впливати на еластометрію та її діагностичну ефективність. Наше дослідження, присвячене вивченню змін жорсткості паренхіми печінки методом зсувнохвильової еластографії/еластометрії у хворих із неалкогольною жировою хворобою печінки, за даними одновимірного кореляційного і множинного лінійного регресійного аналізу, показало, що незалежними детермінантами, асоційованими зі зростанням жорсткості паренхіми печінки, є ступінь інсулінорезистентності, ожиріння та активність трансаміназ.
Роль фосфатидилхоліну в корекції гепатобіліарних розладів при захворюваннях кишечника
Authors: Manzhaliy E.G. , Kosinska S.V.
Published: January 2022

У статті наведено дані про гепатобіліарні розлади при захворюваннях кишечника, описано терапевтичну стратегію їх корекції. Наведено результати власних досліджень ефективності застосування препарату Енерлів® у пацієнтів із цими захворюваннями.
Ефективна інфузійна терапія лікарських уражень печінки та підшлункової залози у хворих на туберкульоз легень
Authors: Gubergrits N.B. , Klochkov O.Ye. , Fomenko P.G.
Published: January 2022

Автори обстежили 328 хворих з туберкульозом легень, у яких внаслідок поліхіміотерапії розвинулися лікарський гепатит і лікарський панкреатит. У пацієнтів сформувався синдром метаболічної інтоксикації, що супроводжувалося підвищенням рівня «середніх молекул» у крові. Під впливом лікування з використанням для інфузійної терапії препарату янтарної кислоти вдалося досягти не лише вірогідного зниження цього показника, але і його нормалізації.
The Assessment of Groundwater Vulnerability towards Contamination using the DRASTIC and NV Indexes in Banjarbaru City, South Borneo, Indonesia
Authors: Zahra Firza Syarifa , Putranto Thomas Triadi
Published: January 2022

The current excessive use of groundwater is exacerbated by human activities, which directly or indirectly trigger surface pollution and gradually affect to the subsurface, including groundwater. Indonesia is one of the developing countries that encounter these obstacles, specifically Banjarbaru City in South Kalimantan Province and its surroundings. Hence, proper management is needed to maintain the sustainable function of groundwater, such as by determining its vulnerability index to pollution. This study used geospatial analysis to determine the intrinsic and extrinsic vulnerability of groundwater via the DRASTIC and NV index methods, respectively, through visual representations on a map. The validation involved the distribution of nitrate and nitrite values to review the relationship between vulnerability levels and the presence of anthropogenic influences. Subsequently, the results of the DRASTIC method showed that the study area is included in three vulnerability indexes, namely low (95-120), medium (120-160), and high (160-186). The NV method further indicated that the groundwater vulnerability indices are divided into four, namely very low (21.2-70), low (70-110), moderate (110-150), and high (150-186). Based on the results, the use of specific vulnerabilities was considered more effective than the intrinsic technique in determining the vulnerability index because the NV method considers land use as a parameter to provide more detailed outcomes.
Physical and Chemical Parameters of Estuarine Waters around South Sulawesi
Authors: Lestari Hasriani Ayu , Samawi Muh. Farid , Faizal Ahmad , Moore Abigail Mary , Jompa Jamaluddin
Published: January 2022

Water quality parameters can be indicators of pollution driving riverine, estuarine and coastal resource degradation. This study evaluated water quality in the downstream, estuarine and surrounding coastal waters of 8 major rivers around the western, southern and eastern coasts of South Sulawesi Province, Indonesia. Data on physical and chemical parameters (salinity, temperature, total dissolved solids (TDS), conductivity, turbidity, pH, dissolved oxygen (DO), nitrate and ammonium) were collected during January 2020. These data were interpolated and mapped using the Kriging tool in ArcGIS 9.3 and analysed using the STORET scale and principle component analysis (PCA).  STORET values indicate moderate to heavy pollution, with the most severe pollution in Makassar City. Dominant defining parameters based on the PCA were nitrate, ammonium and DO at the Malili and Makassar sites,  pH, temperature, TDS and salinity at the Palopo, Bulukumba and Pangkep sites, conductivity at the Takalar site and turbidity at the Pinrang site.
MEMBANGUN PARIWISATA BERSAMA RAKYAT: KAJIAN PARTISIPASI LOKAL DALAM MEMBANGUN DESA WISATA DI DIENG PLATEAU
Authors: Raharjana Destha Titi
Published: January 2022

Development as a process of life change should involve communities as intergral elements. People should not only be regarded as objects of development. The paradigm of the bottom up planning expects people to act as both the subject and object of development. In the context of the development of rural tourism, the planning process should involve the local communities from the beginning. Dieng Plateau as a tourist site has a diversity of attractions, and tourist-oriented villages are designed by local communities to complement the tourist attractions in Dieng. This Study focuses on the participation of the communities in western Dieng in developing tourist villages in their area.Various stages of the planning are completed collectively and then put into action together. By applying action research methods, this study has the following results: (1) the identi cation of problems in the development of rural tourism, (2) the mapping of the potential of rural tourism, and (3) the identi cation of potential inter-agency networking to support sustainable rural tourism in western Dieng.
KONTINUITAS DAN PERUBAHAN MAKNA LAGU KEBANGSAAN INDONESIA RAYA
Authors: Mintargo Wisnu
Published: January 2022

The main objective of this paper is to analyze function of “heroic” Indonesia songs related to the struggle for Indonesian independence ( from 1945 to 1949) from a historical perspective. Through this analysis it is hoped that the process of the past, particularly the history of music development in Indonesia and the background of the use of the “heroic”Indonesia songs, can be reconstructed. Important aspects of Indonesian songs, as this paper shows, include a constructive function for ceremonies and advice for development. The ceremonial character is shown in the song of “Indonesia Raya”. the national anthem.
RITUAL MA’ATENU SEBAGAI MEDIA KONSTRUKSI IDENTITAS KOMUNITAS MUSLIM HATUHAHA DI PELAUW MALUKU TENGAH
Authors: Rumahuru Yance Z.
Published: January 2022

This article aims to expalin identity construction of the Hatuhaha muslim community in Pelauw territory,one which use ritual as its main arena. Data on ma’atenu ritual was collected through of ma’atenuimplementation, and interviewing of informants in Pelauw.There are ritual partisans and ritual leaderswho use symbols in the ritual. The article relates the present ritual to their historical evens and the currentcondition of local community. This research concludes that (1) the ritual has been a useful and strategicmedia for identity construction, and (2) through the ritual implementationof ritual, the interpersonalolidarity of Pelauw poeple or Hatuhaha muslim community has been well-developed, it is knoum locallythe maningkamu relation.