bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality Control of SIR 20 Product Using The Statistical Quality Control (SQC) At PT. WLK
Authors: Hairiyah Nina , Rizki Amalia Raden , Nuryati Nuryati
Published: December 2024

Good quality is an important requirement for companies to gain competitiveness in their products on the market. PT. WLK is a company that produces SIR 20 rubber, which is currently experiencing quality problems such as white spot product defects and contamination that does not meet established quality standards. The aim of this research is to analyze the quality control of SIR 20 products at PT.WLK using the Statistical Quality Control (SQC) approach. This quality control analysis is carried out using statistical tools in the form of check sheets, P control charts, Pareto diagrams and fishbone diagrams. The results of the research carried out show that white spots are caused by several factors, namely humans, machines, environment and methods, while contamination is caused by humans, machines and materials so that it does not meet quality standards. Good quality standards, namely the absence of product defects such as white spots and contamination. Based on the results of research carried out using cause and effect diagrams, factors that cause product defects can be identified, such as human factors that are not careful enough, raw materials that are handled poorly, machines that do not receive enough maintenance, work method factors that often occur deviations in work implementation, and weather factors that often change.
Analisis Perubahan Warna Gurita (Octopus sp.) Selama Pengeringan dengan Pengering Hibrid Bertenaga Surya
Authors: Fatharani Arina , Maissy Faulina , Anis Ulfah , Yuwita Fitri , Firmansyah
Published: December 2024

Kabupaten Kaur, Provinsi Bengkulu merupakan salah satu daerah penghasil gurita. Salah satu produk unggulannya adalah gurita kering dan prosesnya dijemur di bawah sinar matahari langsung. Penjemuran dengan menggunakan sinar matahari langsung dapat menghasilkan warna gurita dengan kualitas rendah karena telah terpapar oleh sinar matahari secara langsung dengan durasi yang cukup lama. Diperlukan alat pengering yang dapat menjaga kualitas warna gurita selama proses pengeringan dan menghindarkan gurita dari kontaminasi di sekitarnya. Salah satu solusi yang dapat dilakukan adalah dengan menggunakan pengering hibrid bertenaga surya. Penelitian ini bertujuan untuk menganalisis dan memodelkan warna gurita selama proses pengeringan menggunakan alat pengering hibrid bertenaga surya. Rancangan percobaan yang digunakan pada penelitian ini adalah Rancangan Acak Kelompok (RAK) dengan 3 taraf perlakuan, yaitu kapasitas gurita 1, 3, dan 6 kg. Perubahan warna yang dianalisis adalah Hue Angle dan Chroma dengan analisis matematis berupa persamaan kinetika dan regresi. Nilai Hue Angle dan Chroma gurita selama proses pengeringan menggunakan pengering hibrid bertenaga surya menunjukkan perbedaan yang tidak signifikan pada setiap perlakuan. Perubahan kedua parameter tersebut kemudian dianalisis lebih lanjut dengan menggunakan persamaan kinetika dan regresi dan didapatkan nilai rerata R² sebesar 0,787. Pemodelan dapat dilakukan pada rentang perlakuan kapasitas gurita sebesar 1-6 kg.
Analisis Pengendalian Kualitas Kernel Pada Stasiun Nut Dan Kernel Di PT X
Authors: Hasbullah Muhammad Hasyim , Darmawan Muhammad Indra , Linangsari Titis , Ningsih Yuliana , Meldayanoor Meldayanoor
Published: December 2024

Kernel processing at PT X has a problem where the resulting kernel has a high level of impurities that can affect the yield of palm kernel oil (PKO) to be processed. Threrefore, it is necessary to control kernel stations, using Statistical Process Control (SPC). The purpose of this research is to analyze kernel quality control at Nut and Kernel Stasions. The method in this study is Statistical Process Control (SPC) using 3 statistical tools namely check sheet, histogram and fishbone diagram. The results of the analysis of the tudy can be known the quality of the kernel in the parameters of dirt leves ecceeding the standards, namely by an average of 9.06% where the most dominant factor is the machine, 2 the main cause is the process of separation on the nutrition of the ripple mill is not optimal. PT X is preferred to be ecamined and regular anda regular ttreatments on the ripple mill machine every morning and the provision of directives to the operators to always adhere to the DOP applicable at each station.
Analisis Oil Losses pada Serat Fiber di Stasiun Press PT. MNO dengan Metode Fishbone Diagram
Authors: Yardani Jesi , Fadilah Muhammad Noor , Ulimaz Almira , Yulianti Wan
Published: December 2024

Based on the results of initial observations at PKMS PT. MNO, it was found that there was oil loss in the fibers during the CPO processing process, especially at the press station. Therefore, research was carried out which aimed to analyze the factors that influence the high level of oil loss in fiber fibers at the press station of PT. MNOs. This research was carried out at PT. MNO located in Tanah Laut Regency, South Kalimantan. The research implementation period starts from 17 October 2022 to 25 January 2023. The data collection method in this research was carried out in 2 ways, namely interviews (direct observation) and literature study. The data was analyzed descriptively qualitatively by comparing the data found in the field with previous literature. The results of the analysis of oil loss at the press station in December 2022 showed that the average in week 1 (press 1) was 4.18, (press 3) 4.67, (press 4) 4.02. Week 2 (press 1) 4.41, (press 3) 4.36, (press 4) 3.97. Week 3 (press 1) 4.41, (press 3) 4.74, (press 4) 4.01 week 4 (press 1) 4.32, (press 3) 4.72, (press 4) 4 .17 which press number 3 in week 1, week 3 and week 4 does not meet company standards, namely 3.89%. From the results of the analysis that has been carried out, the appropriate treatment to prevent more severe oil loss is through routine maintenance of the press machine and the components that support the press station, repairs to the press machine by replacing worn tools, and The directive provides operators to always comply with applicable SOPs.
Pengendalian Kehilangan Minyak Di Final Effluent Menggunakan Metode Statistical Quality Control Pada Proses Pengolahan Crude Palm Oil PT XYZ
Authors: Firdaus Muhammad Reza , Lestari Ema , Fatimah Fatimah , Chalid Sihabuddin
Published: December 2024

PT XYZ is an agro-industrial company that focuses on palm oil processing, mainly producing Crude Palm Oil (CPO) and kernels. The main process carried out by the company is processing fresh fruit bunches (FFB) into CPO and palm kernel (kernel). The level of oil losses in PT's final effluent. XYZ should not exceed 0.40%, but in 3 months, there has been an increase that exceeds the company's standards. This condition can affect CPO production results. Therefore, this research was conducted to analyze oil loss in the final effluent. The method used is Statistical Quality Control (SQC) using three tools, namely Check Sheet to collect data, Histogram to show data distribution, and cause-and-effect diagram to assist in understanding and solving the problems faced. The research results showed that oil loss was the highest, 0.57% in October, 0.46% in November, and 0.45% in December 2023. Therefore, it is necessary to make recommendations for improvements using a cause and effect diagram that includes machine, human and method factors to meet the desired standards, factors that cause high oil losses including lack of attention to equipment maintenance, inconsistent machine cleaning times and overlooked oil citing momentum.
Pengukuran Risiko dan Mitigasi Risiko Menggunakan HOR (House Of Risk) Pada Industri Pengolahan Buah Pisang
Authors: Andanu Odi , Sangadah Hanik Atus , Wulandari Sri , Putri Fina Pradika
Published: December 2024

Banana fruit is one type of fruit that grows well in the tropics. The total production of bananas has increased by 6.85% from 2020 to 2021. There are various potential industries that process banana derivative products, including banana chips in Kepahiyang Regency, Bengkulu. The relatively rapid development of banana chip SMEs is the basis for the need for research related to risk mitigation that may arise in the industry. Research data analysis was carried out using the House of Risk (HOR) method. The results of this study show that 22 risk sources and 14 risk mitigation alternatives are identified in the banana chips industry. From the results of the analysis, it is hoped that several risk mitigation alternatives that can be applied by the banana chips industry will be obtained. The results of the Effectiveness to Difficulty (ETD) rating obtained 3 top ranking results from risk mitigation, namely preparing and providing training for employees (M3) with a value of 20759.25, making planning and controlling raw material inventories more accurate (M10) with a value of 19866, and making and implementing good and correct banana chip production SOP (M4) with a score of 17726.
Karakteristik Kimia dan Organoleptik Stick Puff Pastry Dengan Variasi Penambahan Tepung Daun Kelor (Moringa oleifera)
Authors: Amalia Rizki , Hairiyah Nina , Nuryati Nuryati , Aulia Zaitun
Published: December 2024

Daun kelor (Moringa oleifera) dalam kondisi kering mengandung gizi yang lebih tinggi, seperti protein, serat, karbohidrat, dan kalsium, dibandingkan kondisi basah. Potensi ini dimanfaatkan untuk menghasilkan tepung daun kelor yang digunakan menjadi bahan substitusi pada produk puff pastry stick. Penelitian ini bertujuan untuk (1) mengkarakterisasi sifat kimiawi produk berupa kadar air, kadar abu, kadar protein, dan serat kasar, (2) menganalisis organoleptik melalui metode hedonik berdasarkan warna, aroma, rasa, dan tekstur, serta (3) menentukan formulasi terbaik menggunakan metode Bayes dengan variasi penambahan tepung daun kelor: F0 (tanpa tepung daun kelor), F1 (2,5 g tepung daun kelor), F2 (5 g tepung daun kelor), F3 (7,5 g tepung daun kelor), dan F4 (10 g tepung daun kelor). Hasil karakterisasi kimiawi menunjukkan bahwa puff pastry stick dengan kelima formulasi memenuhi standar mutu SNI untuk cookies, kecuali pada kadar protein formula F0 dan serat kasar. Uji organoleptik yang melibatkan 30 panelis menunjukkan bahwa formula F1 (penambahan 2,5 g tepung daun kelor) paling disukai berdasarkan warna, aroma, rasa, dan tekstur. Dengan demikian, formulasi terbaik pada penelitian ini adalah F1, yang memberikan keseimbangan nutrisi dan tingkat penerimaan organoleptik yang optimal.
Pelatihan Manajemen dan Visualisasi Data Menggunakan Excel untuk Guru Matematika SMP di Kabupaten Karanganyar
Authors: Nirwana Muhammad Bayu , Pratiwi Hasih , Susanti Yuliana , Respatiwulan Respatiwulan , Handayani Sri Sulistijowati , Wijaya Andreas Rony , Pratama Alfito Putra Fajar , Ferawati Kiki
Published: December 2024

Literasi statistik merupakan kemampuan untuk memahami beragam informasi statistik yang dimunculkan di berbagai media. Kemampuan ini meliputi keterampilan dalam menginterpretasikan grafik dan tabel, serta mampu membaca dan memahami statistik dalam berita, media, jajak pendapat, dan lain-lain. Kabupaten Karanganyar merupakan salah satu kabupaten di Provinsi Jawa Tengah yang berbatasan dengan Kota Surakarta dan termasuk sebagai wilayah Karesidenan Surakarta. Pengetahuan mengenai literasi statistik dan implementasinya di wilayah Kabupaten Karanganyar merupakan hal yang penting untuk disampaikan kepada masyarakat, karena berkaitan langsung dengan pemahaman mengenai informasi data statistika dan bagaimana merepresentasikannya. Sebagai ilmu yang mempelajari tentang cara pengumpulan, analisis, dan pengambilan keputusan dari data, pengetahuan tentang statistika merupakan ilmu penunjang yang penting untuk dimiliki oleh masyarakat. Sebagai sasaran peningkatan literasi statistika kali ini Grup Riset Statistika dan Sains Data Bidang Lingkungan dan Kesehatan Program Studi Statistika FMIPA UNS akan melaksanakan pengabdian masyarakat dengan bentuk pelatihan untuk guru dan siswa SMP di Kabupaten Karanganyar melalui forum Musyawarah Guru Mata Pelajaran (MGMP) Matematika. Literasi statistik memerlukan pengetahuan tentang analisis dan visualisasi data yang diberikan untuk meningkatkan pemahaman terkait penerapan metode statistika dengan menggunakan Excel yang sudah banyak dikenal oleh masyarakat.
Inmunodeficiencia combinada severa (IDCS) en la infancia: análisis de la situación en Costa Rica para una mejor visibilización y diagnóstico
Authors: Rodríguez Calvo Samarkandra , Nuñez Morales Kenneth , Wright Rankin Shevanny Marie , Moya Blackwood Miled Jheysha
Published: December 2024

La inmunodeficiencia combinada severa (IDCS) es una enfermedad perteneciente al grupo de inmunodeficiencias primarias (IDP), actualmente conocidas como “Errores Innatos de la Inmunidad”, las cuales son causados por mutaciones genéticas heredadas de forma recesiva ligada al cromosoma X o de manera autosómica recesiva ligada a cromosomas no sexuales; dichas mutaciones afectan la función y producción de los linfocitos T, B y células asesinas naturales (NK) importantes para el funcionamiento del sistema inmune. Los niños con IDCS son muy vulnerables a infecciones graves y recurrentes durante sus primeros meses de vida, lo que resalta la importancia del diagnóstico temprano para iniciar los tratamientos a tiempo. En Costa Rica, la IDCS representa un 9.8% de los 298 casos de IDP reportados, con una prevalencia de 3.3 por cada 100,000 habitantes. El trasplante de células madre hematopoyéticas (TCMH) es el tratamiento más eficaz, ofreciendo posibilidades de cura si se realiza durante los primeros meses de vida. Las complicaciones económicas y psicológicas representan un desafío para los niños y familias costarricenses, donde actores como la Caja Costarricense de Seguro Social (CCSS) son cruciales para brindar apoyo integral y mitigar los gastos de las pruebas diagnósticas y tratamientos. Por tanto, el objetivo de esta revisión teórica es analizar la enfermedad genética denominada “Inmunodeficiencia combinada severa” propiamente en Costa Rica, en cuanto a su epidemiología, métodos de diagnóstico temprano y tratamientos.
Bee Venom and Its Therapeutic Uses
Authors: Morovvati Hassan , Keyhan Haydeh , Koohi Mohammad Kazem , Hassan Jalal
Published: December 2024

The use of honey and other bee products goes back thousands of years. So that even its therapeutic benefits are mentioned in sacred books such as (Veda, the holy book of India), (Bible, the holy book of Christians) and the Quran. Apiterapy is the use of bee products for medical purposes, which includes honey, royal jelly, propolis, flower pollen, and mainly bee venom, which is known as apitoxin
Bee venom consists of at least 18 pharmacologically active compounds including enzymes such as phospholipases, peptide and amino acid compounds such as melittin, which has anti-inflammatory properties. Other properties such as anti-apoptotic and anti-cancer properties have also been mentioned for bee venom.
Since, the lethal dose (LD50) of the poison for humans is 2.8 mg/kg per kilogram of body weight, so it is a safe combination for therapeutic purposes. Bee venom has a high potential in the treatment of inflammatory diseases and the central nervous system such as Parkinson's, Alzheimer's, myotrophic sclerosis and various types of cancer. Also, due to its antiviral activity, it has been effective even against the human immunodeficiency virus (HIV).
Due to the prevalence of diseases in today's societies, it is inevitable to find new treatment solutions. On the other hand, the drugs used in traditional medicine play an important role in the treatment of diseases. Among these natural substances is bee venom. which should be taken into consideration due to its many therapeutic properties in the treatment of diseases.
Cyprinus carpio ile Elde Edilen Surimi Tozundan Üretilen Krakerlerinin Buzdolabı Koşullarında Raf Ömrünün Belirlenmesi
Authors: Karaton Kuzgun Nermin
Published: December 2024

Bu araştırmada, Cyprinus carpio kıyması ile elde edilen surimi tozunun balık krakerlerinin üretimi sonucu buzdolabı koşullarındaki mikrobiyolojik ve kimyasal özelliklerinin belirlenmesini amaçlamıştır. Fileto haline getirilen balıklar kıyma haline getirilip, soğutulmuş su ile iki kez 10 dakika süre ile yıkandı. Üçüncü yıkanma, soğutulmuş %0.3’lük tuz solüsyonu ile 5 dakika karıştırılarak yapılıp ve fazla su süzgeç kullanılarak peynir torbası içinde süzüldü ve daha sonra 60 ±5°C’lik turbo fırında 12 saat kurutuldu ve parçalayıcı da toz haline getirildi. Surimi yozu balık kraker hamuruna eklenip yoğuruldu ve kraker şekli verilip pişirildi. Elde edilen krakerlerin mikrobiyolojik özellikleri incelendi. Elde edilen sonuçlara göre buzdolabı koşullarında 15. günde mikrobiyolojik olarak bozulması gerçekleşti.
Comparison between the degradation effect induced by low pressure air plasma and at atmospheric pressure of diethyl (3h-1-ethoxy-3-phenoxazinylidene) ammonium chloride solution
Authors: Alarcón-Hernández Fidel Benjamín , Yáñez-Carrillo Bartolo , Fuentes-Albarrán María del Carmen , Gadea-Pacheco José Luis
Published: December 2024

The influence of the number of air molecules on the degradation process of a dye (diethyl (3H-1-ethoxy-3-phenoxazinylidene) ammonium chloride) in aqueous solution by plasma was determined. The concentration of the solution was 17.00 mg/L, and it was exposed to plasma treatments performed at two different pressure values (~24 Torr / ~760 Torr), with an exposure duration of 50 minutes per treatment. Four plasma generation conditions (10, 15, 20 and 30 mA) were used at a voltage of 1500 V. The degradation of the dye was determined by UV/VIS spectrophotometry (absorbance and percentage of degradation) and chemical oxygen demand (COD), pH and bioassays with lettuce (Lactuca sativa) seeds. The temperature change was analyzed for both pressures. The degradation of the dye is more significant at atmospheric pressure than at low pressure for all treatments. The higher the plasma power, the greater the degradation.
Negotiation as an alternative conflict resolution in mexican cooperatives
Authors: Domínguez-Sánchez Lorena , Ramírez-Herrera Dania
Published: December 2024

This article analyzes the need for alternative solutions to resolve conflicts in Mexican cooperatives, in a context of distrust towards the judicial system and the complexity of commercial and cooperative law. These circumstances generate uncertainty and can lead to "societal deadlock," affecting the operation of
cooperatives. The research aims to determine how regulatory complexity and the inefficiency of the judicial system contribute to the preference for negotiation as a conflict resolution. The methodology used is qualitative and descriptive, using methods of legal sciences and literature review to examine theoretical and normative frameworks on conflict resolution. The results indicate that distrust in judicial institutions has led to their disuse, suggesting that promoting negotiation could revitalize both the use of the judicial system and the sustainable development of cooperatives in Mexico
Microencapsulation: A Review
Authors: Haribhau Mr. Toge Pratik , S. Kale Assist. Prof. Kalpana , Salve Dr. Megha
Published: December 2024

Microencapsulation Review is a
comprehensive review of the preparation,
production and use of new small self-encapsulated
products, including time-tested technologies
associated with improved micro and large
nanoparticles. Expansion beyond conventional
microcapsules is used for all other microsystems,
both the structure itself and the preparation of the
work. This review includes information on
encapsulation, the physical principle of release
from the capsule wall and/or desorption from the
carrier, preparation and bulk use of microcapsules.
Mucormycosis: A Review
Authors: Shinde Snehal Girish , Chopade Assist.Prof. Babasaheb L. , Salve Dr. Megha
Published: December 2024

Mucormycosis is an angio invasive contamination
that happens because of the fungi mucorales. It is
an extraordinary sickness however more and more
more identified in immunocompromised patients. It
may be labeled into rhino-orbitocerebral,
cutaneous, disseminated, gastrointestinal, and
pulmonary types. Overall elevated mortality fee is
reported, despite the fact that the competitive
remedy is given. The predominant intention and
cause of this evaluation associated with assessment
and Etiopathogenesis of Mucormycosis, fatality of
rhinocerebral Mucormycosis, latest advances in
diagnostic and remedy methods.
Nanogels: “A Miniature Marvel in Drug Delivery and Beyond”
Authors: Florence Athira , Mathan S Mathan S , S Dharan Shaiju , Praji SP Praji SP , Shiji SP Shiji SP , Tigna Paul PB Tigna Paul PB
Published: December 2024

Nanogels, a class of nanoparticles composed of
cross-linked polymer networks, have emerged as a
promising tool in drug delivery and various other
biomedical applications. Their miniature size,
typically ranging from 10 to 200 nanometers,
enables precise control over drug release kinetics,
biodistribution, and targeting. Nanogels offer
several advantages, including high loading capacity
for drugs, proteins, and nucleic acids, as well as
protection of encapsulated payloads from
degradation. Moreover, their tunable
physicochemical properties allow customization for
specific therapeutic needs, such as pH or
temperature responsiveness. Beyond drug delivery,
nanogels hold potential in tissue engineering,
diagnostics, and theranostics. This abstract
highlights the remarkable versatility and potential
of nanogels as miniature marvels poised to
revolutionize biomedical science and healthcare.
Effect of L- Carnitine in Teratospermia and Oligospermia
Authors: Dr. Lokesh. K Dr. Lokesh. K , Purushothaman Dr. Borus , Agwina Xavier Dr.Yashmi , Veerammal Veerammal , Sharma Dr. Suman
Published: December 2024

Teratospermia and oligospermia are male infertility
conditions characterized by abnormal sperm
morphology and low sperm count, respectively.
These conditions often hinder fertility, impacting a
significant number of men worldwide. L-carnitine,
a naturally occurring amino acid derivative, has
garnered interest for its potential therapeutic effects
on male reproductive health, particularly in
improving sperm quality. L-carnitine is known to
play a crucial role in mitochondrial function and
energy metabolism, both essential for sperm
motility and health. This study aims to examine the
effects of L-carnitine supplementation on sperm
quality parameters in men diagnosed with
teratospermia and oligospermia. Existing research
suggests that L-carnitine may enhance sperm
motility, concentration, and morphology,
potentially due to its antioxidative properties,
which reduce oxidative stress—a key factor
contributing to sperm damage. Clinical trials
involving oligospermic and teratospermic men
have demonstrated that L-carnitine
supplementation can lead to a significant increase
in sperm concentration and improvement in sperm
morphology, potentially enhancing fertility
outcomes. The mechanisms underlying these
effects are believed to include improved
mitochondrial activity and reduced lipid
peroxidation within sperm cells, protecting against
damage and promoting healthier sperm
development.
Utilization of Forage Plants by Livestock of Migrating Gaddi Shepherds in low-altitude scrublands of Hamirpur and Una Districts, Himachal Pradesh
Authors: Thakur Prince , Radha Radha
Published: December 2024

This study investigates the forage
species utilised by Gaddi shepherds in the lowaltitude scrublands of Hamirpur district, Himachal
Pradesh, during their seasonal migrations. The
Gaddi community employs traditional knowledge
to oversee livestock health and nutrition by
utilising a range of plant resources that are welladapted to the warmer, low-altitude environment.
Key forage species identified are
Lepidagathiscuspidata, Medicago denticulata,
Cynodondactylon, and Grewia optiva, noted for
their carbohydrate-rich content and capacity to
meet the energy requirements of livestock in these
regions. Nutritional analyses reveal significant
variability in moisture, ash, protein, fibre, and
carbohydrate levels across different species,
highlighting the adaptive forage potential of
scrubland flora. The results emphasise the
sustainable grazing methods employed by Gaddi
shepherds, which play a crucial role in preserving
biodiversity and maintaining ecological balance in
low-altitude scrubland ecosystems. This study
deepens the comprehension of forage resources that
support pastoral systems and highlights the
importance of maintaining traditional knowledge
for sustainable livestock management.
Preparation and evaluation of wound healing cream of Tridax Procumbene
Authors: Dr. L.D Hingane Sir Dr. L.D Hingane Sir , Shruti Maroti Ms. Jingure , Aishwarya A. Ms. Kemdharne
Published: December 2024

Tridax procumbens, commonly known as
coatbuttons or tridax daisy, is a species of flowering
plant in the family Asteraceae. India’s fields are
home to a prevalent weed called Tridax
procumbens. Ancient ages have long utilized the
leaves of Tridax procumbens to cure wounds. The
mature leaves were crushed to make a paste and
were further rubbed over the wounded area. They
are also used as anticoagulant, antifungal and insect
repellent by many civilization. Tridax
procumbenslinn. Strongly proved for its antiinflammatory and analgesic activity in animal study
and it is also used to treat boils , blisters and cuts
by local healers in parts of India.This ongoing
study aims to evaluate this wound-healing activity
and further formulate an herbal cream from the
paste/extract of T. Procumbens. The extraction
process involved isolating bioactive compounds
from the aerial parts of Tridax procumbens,
followed by phytochemical screening. Theherbal
extract was then incorporated into a cream base,
ensuring optimal consistency, stability, and pH
suitable for dermal application. The formulated
cream underwent rigorous evaluation for its
physical properties. This formulation holds promise
as a natural, effective alternative to synthetic
topical agents, warranting further clinical studies to
confirm its efficacy and safety for various
dermatological application
The Novel innovation oncurcumin: Nanoform for the treatment of cancer
Authors: Rasne GurudattaD.. , Pendharkar Yash K. , Dhewale Mrs. Snehal , VardhanandPawar VardhanandPawar , Rajput. Unnati
Published: December 2024

In view of the disparate therapeutic and
pharmacokinetic propreties of curcumin. Itisleading
in the medicinal, pharmaceutic, nutraceutical,
cosmetics, and nutritional. These iscrucialbecause
of lots of effect like as anti-inflamantory, wound
relieve, anti-oxidant, anti-microial, cytoprotective,
anti-cancer, &immunomodulatory effects. A major
reason for the beneficial action of curcumin is the
existence of identical yellow-colouredpolyphenolic
compound known as “Curcumin”. It is curing of
multiple of disease likeascardiovascular and
neurological disease, sugar diabetes, rheumatic &
cancer. By using nanoformulationscurcumin& its
result support to arrange new treatment modalities,
particularly in cancer, a like the reason that of their
best bioaccessibility& solubility of nanocurcumin
while differentiate turmeric. These analyze handle
the varied application of curcumin nanoparticles in
cancer therapy and much aim realize which way
that the immunological level of the cancer cell
Prevalence of Burnout Syndrome in Working Nurses
Authors: Shaikh Bushra , Shaikh Dr. Afreen , Jerome Dr. Albin
Published: December 2024

Background: Burnout is a condition arising from
chronic workplace stress that hasn't been effectively
managed. Burnout Syndrome is characterized by
three key dimensions:
1. Feeling of energy depletion or exhaustion
2. Growing emotional detachment from one’s
work, often accompanied by negative or
cynical attitudes toward job responsibilities.
3. Reduced professional efficacy.
This study aims to find the prevalence of burnout
syndrome in working nurses.
Method: This descriptive type of observational
study included 236 participants. All the participants
responded to the study. The MBI questionnaire was
used to find the prevalence of burnout syndrome in
nurses.
Result: The prevalence of Burnout Syndrome in
working nurses was 70% and the 30% nurses were
being at the risk of future burnout. Occupational
Exhaustion is observed in almost 83% participants.
Depersonalization is observed in almost 91% of
participants. 87%, do not have a positive view of
professional achievement or do not sense fulfillment
in the workplace.
Conclusion: Nurses in Pune present with high
degree for the three dimension of burnout
syndrome, namely, emotional exhaustion,
depersonalization, and professional efficacy. For
this reason, they are in the high degree of burnout
syndrome and some of them are near to moderate
and high degree of burnout syndrome.
Prescribing Pattern and Cost Analysis of Corticosteroids and Bronchodilators in Pulmonology Department in a Tertiary Care Hospital
Authors: Cahko Christina Grace , Vishal CS Vishal CS , Shanbog Ezekiel , Sabrina K Sabrina K , Ali Ahamadi Ali Ahamadi , Kumar Sateesh , Padma L Padma L , Yashaswini Yashaswini
Published: December 2024

Bronchodilators and Corticosteroids are two
common types of medications used to manage
respiratory conditions, particularly Asthma and
COPD. These medications are often used in
combination to provide comprehensive care for
respiratory conditions. The primary objective of
our study was to evaluate the prescribing pattern of
bronchodilators and corticosteroids among the
inpatients. The study also focuses on analyzing the
cost of the treatment provided. Across-sectional
study was conducted among 300 patients in a
tertiary care hospital in Bangalore. The study
included adult and geriatric inpatients receiving
corticosteroids, bronchodilators, or both as
medications. The data were collected from patient
case profile, prescription and Jan Aushadhi Sugam
App and noted in a self-designed data collection
form. SPSS and MS Excel applications were used
to do statistical analysis on the acquired data.
Among 300 patients, 21.3% were in the age group
between 61-70 years of age. By 65%, male patients
outnumbered female patients. COPD and asthma
were the most common diagnosis. Out of 300
patients, 173 patients had comorbidities and the
most common comorbidity was HTN (93), DM
(41) and PTB (21). Most commonly used
combination therapy was ipratropium bromide and
levosalbutamol (219) and budesonide as
monotherapy (228). Inhalational route (478) of
drug administration was the preferred route as
compared to other routes. Cost analysis study
revealed that mean average cost of generic drug
(287.54) is much less than the mean average cost
branded drugs (1011.75).This study provides
adequate insights into the overall pattern of
bronchodilators and corticosteroids used among
various respiratory diseases. Patients must be
provided with adequate information and knowledge
in order to improve the medication adherence.
Physicians should be encouraged to increase
generic prescribing in order to minimize the
financial burden on patients.
“Formulation and Evaluation of Nano-Gel Using Effective Combination of Acyclovir and Omeprazole for Enhanced AntiViral Activity”
Authors: Tambade Mayuresh , Shriwas Shweta , Kumar Jatav Dr. Rakesh
Published: December 2024

The aim of the research is to formulate nano
transdermal using effective combination ofacyclovir
and omeprazole to enhanced anti-viral activity to
evaluate the Preformulating characters to formulate
acyclovir and omeprazole nanogel by solvent
diffusion method to Characterization and evaluation
of formulated nanogel compare the in-vitro drug
release with marketed formulation. It can be
concluded that the experimental study carried out that
the formulation of a Nanogel containing anti-viral
drug and anti-ulcer drug yields a formulation with
spherical and smooth surface, nano in size range. The
prepared nanogel was opaque, without any lumps,
particle and aggregates. So, all the formulations are
homogenous. Based on all the factors the nanogel
drug delivery system F9 shows good drug content
compare to other. The particle size of the nanogel
formulation is optimum and it is less than 1000 nm.
So, it concluded that the particles are in tiny and nano
in size range. All nanogel formulations shows pH in
the range of 6.1 to 6.9. Formulation F9 shows highest
pH of 6.9. Because the pH range of nanogel were 1
to 7 pH. Based on the Spreadability diameter study it
shown the nanogel is having good Spreadability.
Nanogel formulations shown viscosity range from
3268-3528 cps. It concluded that they are stable in
nature. Formulation F9 shows highest percentage of
drug release compare to other formulations. In-vitro
diffusion studies show F9 formulation shows
controlled release pattern of drug from the
formulation. The formulation was found to be stable
in short term stability studies. Here we have selected
F9 has an optimized formulation which shown good
morphological features, drug content efficiency and
controlled drug release. Hence the F9 formulation is
efficient than the marketed formulation of acyclovir
ointment (ACIVIR).
EFFECT OF PROCESSED ABATTOIR WASTE (BOVINE BLOOD RUMEN DIGESTA MIXTURE) AS PARTIAL REPLACEMENT FOR SOYABEANS ON PERFORMANCE OF BROILER CHICKENS
Authors: IYANDA Adegboyega Ibukun , ODUTAYO Olusola Joshua , Damilola  Janet IBIGBAMI  , Adedayo Akinade ADEYEMO  , Kemi Ruth IDOWU  , Aramide Anuoluwapo ADENIYI  , Omotoyosi FARINRE  , Hikmah Olamide OROBIYI  , Mubarak Dolapo AREMU
Published: December 2024

A total of 288-day-old chicks were used to investigate the effect of processed bovine blood rumen digesta mixture (BBRDM) as partial replacement for soyabeans on performance of broiler chickens. Considerable quantities of fresh bovine blood and rumen digesta were collected on weight/weight basis using the 1:2 ratio, processed via heat treatment for 2 hours 30 minutes and thereafter sun-dried for five days until it was dried. The BBRDM was used to formulate four dietary treatments consisting of 0 %, 20 %, 40 % and 60 % as partial replacement for soyabeans. The experimental birds were balanced for weight and divided into four (4) treatment groups of seventy-two (72) birds each. Each group was further divided into 4 subgroups comprising of 18 birds each serving as replicate. Data collected on the response variables (growth performance indices, haematological parameters and carcass traits) were subjected to One-way Analysis of Variance. Results revealed non-significant variations in all the growth, haematological indices (at starter and finishing phases) as well as carcass traits measured. In conclusion, partial substitution of soya beans meal with 60 % BBRDM in the diet is recommended for broiler chicken production for enhanced growth, better blood function, health status as well as carcass yield with probable reduction in the production cost.
HUSBANDRY PRACTICE AND MORPHOLOGICAL CHARACTERIZATION OF INDIGENOUS GOATS
Authors: ASSEFA Tesfamichael , ALEMAYEHU Kefyalew , TESEMA Zeleke
Published: December 2024

This study aimed at characterizing the husbandry practice and morphology of the goat population in the study area. The data were collected through face-to-face personal interviews, focus group discussions and measurements of the morphological characteristics of goats. Data on 17 morphological traits were collected from 510 goats (411 females and 99 males) and about 180 households participated in the survey. Data were analysed using different procedures of the Statistical Analysis System. Crop production, goat rearing, cattle rearing, sheep rearing and apiculture were the major farming activities with index values of 0.41, 0.27, 0.23, 0.08 and 0.003, respectively. The source of immediate cash income, household meat consumption and a means of saving were the main reasons for keeping goats. The average flock size of goats per household is 6.72 ± 3.71. In the lowland areas, most of the kidding occurred in January, September and July. However, in midland and highland areas, September, October and January were ranked 1st, 2nd and 3rd. Most (75.0 to 93.0 %) of farmers culled female goats due to various reasons. The overall mean (± SE) market age for male and female goats were 8.88 ± 0.17 and 9.28 ± 0.16 months, respectively. Most of the goat keepers in the highland (93.3 % and 40.0 %), midland (91.7 % and 38.3 %) and lowland (96.7 % and 95.0 %) agro-ecologies have reported the practice of free grazing during the dry and wet seasons, respectively. Pasteurellosis, Goat pox and Anthrax were the possible economically important diseases in the study areas with index values of 0.298, 0.172 and 0.168, respectively. Feed shortage, disease prevalence, drought and labour shortage were the most limiting factors for goat production, although their importance was not similar across agro-ecologies. Sex, age and agroecology had a significant influence on the body weight and morphological characteristics of goats. Promoting alternative forage development strategies, improved forages and efficient feed utilization and conservation options are important to alleviate feed shortage and enhance drought resilience capacity. In addition, designing and implementing of community-based genetic improvement program through within-breed selection could improve the productivity of indigenous goats.
Supply and Demand in the Training of Quantum Software Engineering Workforce
Authors: Aparicio-Morales Álvaro M. , Moguel Enrique , Garcia-Alonso José , Fernandez Alejandro , Bibbo Luis Mariano , Murillo Juan M.
Published: December 2024

Quantum Technologies are experiencing significant growth due to substantial investments made by governments worldwide. These investments aim to enhance global competitiveness in this field and position countries as key players. However, facing the changes of this new paradigm requires an increment in the workforce with specialized expertise in Quantum Technologies, particularly in the area of Quantum Computing. In this paper, we present a concise overview of the current quantum computing education offers and an outline of the current job offer landscape. We highlight essential elements for individuals interested in building a career profile in quantum software engineering, including understanding the professional requirements that experts and companies have established. The main goal of this paper is to offer an overview of the current educational and professional landscape in the quantum software engineering field, empowering the next generation of software engineers to thrive in a quantum technology-driven future that will profoundly impact human lives.
Análisis comparativo entre el método basado en desplazamientos (MBD) y el método basado en fuerzas (MBF) aplicado a edificio dual de 5 pisos
Authors: Zavala Cáceres Guimo , Villarreal Castro Genner
Published: December 2024

Esta investigación se aborda con el propósito de establecer el control de los efectos de mayores derivas en edificaciones aplicando los métodos de lineamientos sísmicos conforme a parámetros de la NTP E0.30, como estrategia de diseño bajo el enfoque del método basado en desplazamientos. La estructura como muestra es una edificación común con un sistema dual de 5 pisos que está ubicado en la ciudad de Arequipa, distrito de Cerro Colorado, para documentar cada cambio estructural en el proyecto se apoya en la utilización del programa informático de análisis estructural ETABS.  Utilizando métodos de diseño sísmico basados en fuerzas como fundamento base y consiguientemente ser evaluado utilizando métodos de diseño sísmico basados en desplazamientos, que demostró buenas prácticas de ingeniería de diseño. Éste estudio se centra en la implementación del nuevo enfoque utilizando métodos modernos de diseño sísmico planteadas por Priestley et al., 2007 para evaluar edificios específicos y compararlos con los estándares destacados. Este nivel de trabajo es de naturaleza puramente teórica, la investigación de los métodos de diseño sísmico planteados se lleva a cabo a través de los estándares de diseño sísmico, permisibles en la norma peruana de diseño sismorresistente del RNE, el principal objetivo de este estudio es alcanzar los resultados esperados del comportamiento de las edificaciones bajo las aceleraciones del terreno, se determinaron los posibles daños de la estructura en caso de sismos severos o sismo de diseño así como para los diferentes niveles de sismo, se verificaron los máximos desplazamientos de la estructura, y se identificaron la condiciones contrapuestas de los métodos de delineamientos planteados.
Thermo-Mechanical Process-Induced Residual Stresses and Deformation Analysis During Manufacturing of Hull Structure
Authors: Ahmed Saad , Asif Muhammad , Ali Zaidi Asad
Published: December 2024

Hull structures such as stiffened plates and thin panels are the building blocks of ship structures, and therefore understanding their manufacturing process is of utmost importance. The welding process has been widely used to join stiffeners, stringers, and girders onto the plate. The thermo-mechanical loading and constraints during the welding process generally induced deformations and residual stresses. A deep understanding of the process parameters during thermo-mechanical processing is required to control the process-induced deformation. Therefore, this study aims to investigate the deformation and thermal stress generation in hull structures (panels/stiffened plates) during thermo-mechanical processes such as welding. A finite element modeling approach was proposed while incorporating the thermal and nonlinear thermo-elastic-plastic material behavior. The thin panels with different geometrical configurations and boundary conditions were simulated using steady state and transient heat-transfer-stress deformations analysis to simulate real-life scenarios. Both modeling approaches give a useful insight into understanding the complex nature of deformation and built-up residual stresses. However, the transient heat transfer-stress deformation analysis results were found in a reasonably good agreement with experimental data.
Diseño Sismorresistente de un Sistema de Muros Estructurales Aplicando la Norma E.030 del 2003 y 2018 en la Ciudad de La Libertad
Authors: Rupay Vargas Marcos Josué , Parra Lavado Regner Raúl , López Yarango Jorge Santiago
Published: December 2024

El análisis comparativo se centra en investigar las discrepancias entre las normativas E.030 de 2003 y 2018 en relación con el diseño antisísmico. Este estudio se realiza en el contexto de estructuras de muros estructurales destinadas para un Centro Educativo ubicado en la ciudad de La Libertad. Se contrastan varios aspectos importantes, como los períodos de vibración, el porcentaje de masa participativa, el espectro de diseño, la deformación y diversas fuerzas, tales como la fuerza cortante basal estática y dinámica, además de las fuerzas máximas de diseño, como el momento flector, el cortante y la fuerza axial.Utilizando el software Etabs v.20 para modelar las estructuras, se observaron variaciones significativas en los resultados al aplicar las normas según el año del 2003 y 2018. Es relevante señalar que la normativa de 2018 produce resultados intermedios en cuanto a los períodos modales para ambas estructuras, tanto en el análisis estático como en el dinámico. En síntesis, se demuestra que las modificaciones en la normativa tienen una influencia notable en el diseño y la respuesta sísmica de las estructuras, especialmente en aquellas con irregularidades, y es fundamental tener en cuenta estos aspectos al llevar a cabo análisis y diseño estructural.
Pengembangan Iklan Animasi 3D untuk Pemasaran Global dalam Upaya Pemberdayaan UMKM Kerajinan Pengolahan Limbah Kayu Jati di UD. Akar Dewa Jati Kab. Situbondo, Dengan Pendekatan Project Based Learning
Authors: Zikky Moh. , Aji Rendra Suprobo , Rante Hestiasari , Darmawan Zakha Maisat Eka , Dianta Ashafidz Fauzan , Susanto Dwi , Alim Ikhsan Nur , Arijatno Mochamad Rafi Dimas Putra , Nurrahman Fuad Zaki , Ompusungu Annete Phoebe Jovanca
Published: December 2024

Usaha Mikro, Kecil, dan Menengah (UMKM) memainkan peran signifikan dalam perekonomian Indonesia, dengan kontribusi besar terhadap Produk Domestik Bruto (PDB) dan penyerapan tenaga kerja, Salah satu kendala yang dihadapi oleh UMKM di Indonesia adalah sektor pemasaran khususnya untuk pasar internasional. Di era digital saat ini perlu dikembangkan terobosan baru yang dapat meningkatkan ceruk pasar internasional. UD. Akar Dewa Jati Situbondo, merupakan UMKM yang merupakan sebuah usaha di bidang kerajinan limbah akar kayu jati yang berorientasi ekspor. Pembuatan Iklan animasi 3D berbahasa Inggris yang atraktif merupakan strategi yang bisa dikembangkan. Dalam pengabdian ini berorientasi pada peningkatan kompetensi SDM pada UD. Akar Dewa Jati Situbondo dalam pembuatan iklan Animasi 3D berbahasa inggris dengan menggunakan pendekatan PBL (Project Based Learning). Hasil dari pengabdian ini, adalah pendekatan PBL terbukti efektif dalam pembuatan konten multimedia dalam bidang pemasaran digital. Dalam pelaksanaan PBL menggunakan variabel penelitian yaitu Kreativitas, Pemecahan masalah, Kolaborasi, Pemahaman masalah. Pada masing-masing variabel yang digunakan untuk mengukur pelaksanaan pengabdian ini didapatkan nilai diatas 85, sehingga dapat disimpulkan kegiatan pelaksanaan pengabdian pembuatan Iklan 3D berbahasa Inggris dengan pendekatan PBL berjalan dengan baik.
Potential Biomarkers in Myocardial Fibrosis: A Bioinformatic Analysis
Authors: Cheng-Mei Wang , Luo Gang , Liu Ping , Ren Wei , Yang Sijin
Published: December 2024

Abstract Background Myocardial fibrosis (MF) occurs throughout the onset and progression of cardiovascular disease, and early diagnosis of MF is beneficial for improving cardiac function, but there is a lack of research on early biomarkers of MF. Objectives Utilizing bioinformatics techniques, we identified potential biomarkers for MF. Methods Datasets related to MF were sourced from the GEO database. After processing the data, differentially expressed genes were screened. Differentially expressed genes were enriched, and subsequently, protein-protein interaction (PPI) was performed to analyze the differential genes. The associated miRNAs and transcription factors were predicted for these core genes. Finally, ROC validation was performed on the core genes to determine their specificity and sensitivity as potential biomarkers. The level of significance adopted was 5% (p < 0.05). Results A total of 91 differentially expressed genes were identified, and PPI analysis yielded 31 central genes. Enrichment analysis showed that apoptosis, collagen, extracellular matrix, cell adhesion, and inflammation were involved in MF. One hundred and forty-two potential miRNAs were identified. the transcription factors JUN, NF-κB1, SP1, RELA, serum response factor (SRF), and STAT3 were enriched in most of the core targets. Ultimately, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2, and ITGB8 had higher diagnostic accuracy and sensitivity in predicting MF based on ROC curve analysis. Conclusion Eight genes, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2, and ITGB8, can serve as candidate biomarkers for MF. Processes such as cellular apoptosis, collagen protein synthesis, extracellular matrix formation, cellular adhesion, and inflammation are implicated in the development of MF.