bluuebunny/crossref_metadata_2025 huggingface dataset:
Malaria treatment failure after Artemisinin-based combination therapy: A case series of children managed at a private tertiary hospital in southwest Nigeria
Authors: Fatunla O.A.T. , Irek E.O.. , Oyebanji A.H. , Adisa S.O. , Jesulana T.E. , Jesulana T.E. , Ajibola T.O.
Published: April 2023

Malaria treatment failure is the inability to clear parasitaemia after antimalarial drug administration. There are reports of treatment failure with  artemisinin-based combination therapy (ACT) in Nigeria but few reported among children. We report three paediatric cases of treatment failure with ACT  admitted at a private tertiary hospital in Nigeria in early 2022. All three were ‘under-fives’ admitted for open-heart surgery, major flame burns, and  cerebral malaria respectively. They had symptomatic Plasmodium falciparum infection but one had mixed P. falciparum and Plasmodium vivax infections.  Cases 1 and 2 were initially given oral artemether-lumefantrine while case 3 received intravenous artesunate. Despite appropriate antimalarial drug  compliance, all the 3 still had fever with heavy parasitaemia. They subsequently received intravenous quinine, with improvement within the first 24 hours  of therapy, and no longer had fever at the fourth week of follow-up. Although ACT resistance was not established, poor drug quality may have  contributed to treatment failure. There is a need for pharmacovigilance of anti-malarial in Nigeria. 

 

French title: Échec du traitement du paludisme après une polythérapie à base d'artémisinine: une série de cas d'enfants pris en charge dans un hôpital tertiaire privé du sud-ouest du Nigeria

L'échec du traitement du paludisme est l'incapacité à éliminer la parasitémie après l'administration d'un médicament antipaludique. Il y a des rapports  d'échec de traitement avec la thérapie combinée à base d'artémisinine (ACT) au Nigeria, mais peu ont été signalés chez les enfants. Nous rapportons trois  cas pédiatriques d'échec de traitement avec ACT admis dans un hôpital tertiaire privé au Nigeria au début de 2022. Tous trois étaient des « moins de  cinq ans » admis pour une chirurgie à cœur ouvert, des brûlures graves par la flamme et un paludisme cérébral, respectivement. Ils avaient une  infection symptomatique à Plasmodium falciparum mais un avait des infections mixtes à P. falciparum et Plasmodium vivax. Les cas 1 et 2 ont  initialement reçu de l'artéméther-luméfantrine par voie orale tandis que le cas 3 a reçu de l'artésunate par voie intraveineuse. Malgré une bonne  observance des médicaments antipaludiques, tous les 3 avaient encore de la fièvre avec une forte parasitémie. Ils ont ensuite reçu de la quinine par voie  intraveineuse, avec une amélioration dans les 24 premières heures de traitement, et n'avaient plus de fièvre à la quatrième semaine de suivi. Bien que la  résistance à l'ACT n'ait pas été établie, la mauvaise qualité des médicaments peut avoir contribué à l'échec du traitement. Il y a un besoin de  pharmacovigilance des antipaludéens au Nigeria.
Real Time Web-based System to Detect Military Aircraft Using RESNET-50 Algorithm
Authors: Venkata Sudhakar C , Deekshitha Limbakar , Kummari Charan , Pintu Sah Rauniyar , Kessamsetty Mahathi
Published: April 2023

As target detection in remote sensing imaging depends on aircraft type recognition, it is essential in both civil and military applications. The job is made more difficult by the existence of fine-grained features, which can result in significant intra-class changes due to variations in size, posture, and angle, as well as modest inter class changes due to very similar subcategories. This kind of system can be helpful for military security as recognition of the type of aircraft is very critical to the decisions being made. There are several existing ways which uses methods like Radar System and Radio footprints, Speed etc., to detect type of Aircraft. Although these methods are massively costly and still cannot detect the type of Aircraft accurately. In this paper aircraft is detected using ResNet-50, Advance State of Art Object Detection Algorithm implementing in Anaconda tool with train accuracy is 98% & validate accuracy is 75%. A crucial area of artificial intelligence is object detection, which enables computer systems to perceive their surroundings by identifying things in visual pictures or movies. In case of any dangerous Aircraft, the system will have capability to raise alarm and Alert using Audio Sirens. The software requirement for this project is python, 3.6/anaconda, or newer and necessary python modules.
Controlling Media Player Using Hand Gestures
Authors: Chakradhar K S , Rejinthala Lakshmi Prasanna , Sree Rama Brunda salla chowdary , Pola Bharathi , Petlu Bhargava
Published: April 2023

Computer usage is increasing rapidly day by day but the input devices are limited and to access them, we need to be near the screen. To overcome this problem and control the screen, we can use hand gestures. For every operation, we used different hand gestures. We proposed a python program to control the media player through hand gestures. In this method, we used libraries like OpenCV, Media Pipe, PyAuto GUI, and other libraries to capture the video, provide ready-to-use ML solutions and automate your GUI and programmatically control your keyboard and mouse. Hand gestures will be used as the input for providing natural interaction by reducing external hardware interaction. The whole process is divided into two steps. Firstly, gesture recognition through the camera is done by OpenCV and media Pipe helps to identify the gesture b its position, and the respective command is executed. Secondly, PyAuto GUI is used to automate the keyboard and controls the media player.
Data Processing Method for Artificial Neural Network ANN Based Microgrid Protection Model
Authors: Sanghita Baidya , Champa Nandi
Published: April 2023

Effective fault detection and isolation technologies are very necessary for uninterrupted power supply and for making a flexible protection scheme. Almost all protection schemes in the power system are based on data exchange among protection units through a strong communication structure. Thus, it is important to deal with a large amount of data. Artificial Intelligence (AI) is one of the key factors in this regard. AI has several sections and Artificial Neural Network (ANN) is one of them. It is suggested to implement the ANN-based models while working with big data. The existing protection models are facing difficulties while trying to deal with big data. Thus ANN-based approaches have come into the front line in advanced power system networks. The performance of the ANN model is depending on the training of the data set. Hence in this work, we are focusing on preparing the data to provide input in the ANN model. The principal component analysis (PCA) method is applied here for reduced the dimension of a large number of data sets. The new data set is used to run the k-means clustering algorithm. It is shown that the clustering is more accurate with the processed data set by PCA. Therefore, the prepared data set is used to run the ANN model that has a smaller size with higher information and minimum computational time. This study shows the data preparation part to train the ANN model.
Evaluation of Different Soybean Genotypes in Terms of Isoflavones, Antioxidants and Some Quality Traits
Authors: ERGİN Nurgül , GÜLÜMSER Erdem , MUT Hanife , BAŞARAN Uğur , ÇOPUR DOĞRUSÖZ Medine
Published: April 2023

Soybean (Glycine max L.) varieties around the world have different quality characteristics that determine their use and nutritional value. In this study, the isoflavones (daidzein and genistein), isoflavone glycosides (daidzin and genistin), total flavonoid, total phenolic, free radical scavenging activity (DPPH), crude protein, crude fiber, fat, and condensed tannins contents of Turkish origin soybean genotypes were determined. The isoflavone contents were determined in the LC-MS/MS, antioxidants and condensed tannins content in the spectrophotometer, and other quality traits were determined in the NIRS device. The daidzein and genistein contents ranged between 0.035-0.446 and 0.308-1.188 ppm, respectively. The genistin content (0.254-8.906 ppm) was more variable than daidzin (0.388-1.006 ppm). Soybean genotypes exhibited high antioxidant characteristics. The crude protein contents were ranged from 36.127-40.603%. As a result, all genotypes examined were found to be rich in bioactive metabolites, therefore, high-quality raw materials for food production and human consumption.
Rendimiento neuromuscular en niños tenistas de diferentes niveles de práctica: recreativos vs competitivos (Neuromuscular performance in pre-pubertal tennis players of different levels of practice: recreational vs. Competitive)
Authors: Cruz Wendy R. , Parra  Juan E. , Samudio   Laura V. , Trujillo  David R. , Celis-Moreno Mauricio
Published: April 2023

El tenis es un deporte que depende del rendimiento neuromuscular para tener un mejor desempeño, independientemente del nivel de práctica. El objetivo de este estudio fue describir la asociación entre variables antropométricas y rendimiento neuromuscular niños tenistas (n=36) pre-púberes, en un rango de edad de (10.15-12.77) años, además de compararlos según el nivel de práctica. Los participantes fueron divididos en dos grupos, el primero fue denominado “competitivos”, con ranking nacional (n=18) edad (11.66 ± .72) y el segundo denominado “recreativos” sin ranking nacional (n=18) edad (11.52 ± .82). Se realizó una antropometría básica incluyendo estatura, peso y masa grasa, además se ejecutaron pruebas de CMJ, lanzamientos de balón medicinal de 2kg con tres técnicas diferentes (derecha, revés y por encima de la cabeza), y velocidades de 10m y 20m. En la comparación de grupos se encontraron diferencias (p≤0.01) en la masa grasa, CMJ y la prueba de 20m, y (p≤0.05) en los lanzamientos de balón medicinal y 10m. La estatura y el CMJ se asociaron a las otras variables evaluadas y los jugadores de nivel competitivo tuvieron mejores atributos antropométricos y neuromusculares que sus contemporáneos de nivel recreativo, tal vez por adaptaciones en edades pre-púberas al tiempo dedicado a la práctica, y a la exigencia competitiva.
Palabras clave: Tenis, deporte infanto-juvenil, potencia, velocidad.
Abstract. Tennis is a sport that depends on neuromuscular performance during the game, regardless of the level of practice. This study aimed to describe the association between anthropometric and neuromuscular performance in pre-pubertal children tennis players (n=36) aged (10.15-12.77) years and compare them according to the level of practice. The participants were divided into two groups; the first was called "competitive," with a national ranking (n=18) aged (11.66 ± .72), and the second called "recreational" non-ranked in the national system (n=18) aged (11.52 ± .82). Basic anthropometry, including height, weight, and fat mass, was performed, as well as CMJ tests, 2kg medicine ball throws with three different techniques (forehand, backhand, and overhead), and 10m and 20m distance speeds. The comparison by groups t- student test found differences of (p≤0.01) in fat mass, CMJ, and the 20m test, and (p≤0.05) in the medicine ball throw and 10m. The height and CMJ variables were strongly associated with the other variables evaluated and competitive-level players had fitter anthropometric and neuromuscular attributes than their recreational-level contemporaries, perhaps due to adaptations in pre-pubertal ages to the time dedicated to the practice and the competitive demand.
Keywords: Tennis, youth sports, power, speed.
Available phosphorus in soil from three sources and their effect on biomass and corn root
development
Authors: Ramírez Ricardo , Sequeraϯ Omaira
Published: April 2023

Phosphorus deficiency in the country is very common, to overcome the problem high soluble phosphates are applied, the use a less soluble acidulated phosphate rock with sulfuric acid (RFA) is one economical alternative. The partial substitution of sulfuric acid by ammonium thiosulfate in the acidulation process (R30T) has proven feasible. The objective of this study was to prove the effect of these P sources on the maize behavior. Two soils were used a neutral and acidic one. Four doses of P treatments were used: 0, 70, 140 and 210 mg.kg-1, in a glasshouse experiment. 35 days after planting plants were harvest and soil and root samples were taken for phosphorus analysis and determination of dry matter, root length (LR) and root volume (VR). Partial substitution of sulfuric acid by ammonium thiosulfate does not affect the quality of the acidulated rock. A close relationship between biomass and P concentration in the corn tops with residual soil P, LR and VR increased with the first increase of soil P, successive increments of P produced a decrease in roots size. The LR and VR relationship with P uptake and biomass was not the same in the two soils, in the acidic soil there was a higher dependence on P uptake than in the neutral soil.
The use of Anakinra in a patient with a combination of two autoinflammatory diseases: Familial Mediterranean fever and gout
Authors: Eliseev M. S. , Zheliabina O. V. , Nasonov E. L. , Cheremushkina E. V. , Korotkova T. A. , Panevin T. S.
Published: April 2023

Along with familial Mediterranean fever (FMF), it is now considered an autoinflammatory disease and gout. The commonality of the basic mechanisms of inflammation underlying the pathogenesis of FMF and gout predetermines the possibility of using similar therapies aimed at stopping and preventing seizures (colchicine and IL-1 inhibitors). A clinical case is presented describing the presence of a combination of FMF and gout in a patient. The patient was prescribed anakinra, which proved to be effective both as a treatment for FMF and gout. The appointment of an IL-1 inhibitor fully justified expectations: already after the first injection of anakinra, the intensity of swelling and pain in the joints decreased in the patient.
Association of glutathione-S-transferase gene polymorphisms with various disease (review of foreign studies)
Authors: Bereza Ivan Andreevich , Shaikhova Daria Ramilevna , Amromina Anna Mikhailovna
Published: April 2023

Introduction. This review is devoted to the association of GSTM1, GSTT1, GSTP1 gene polymorphisms with various diseases in foreign literature sources.
Material and methods. For this article, we used data published in foreign literature over the past 11 years. medline was extensively searched for eligible studies using the Pubmed search engine, and 30 studies were eventually selected for inclusion in this review.
Results. This review showed that researchers all over the world have repeatedly tried to evaluate the relationship between GST polymorphisms and various diseases, but in some cases received conflicting results. At the same time, many studies have found an association of pathologies with both single GST gene polymorphisms and combined polymorphic variants, which indicates a complex effect of antioxidant system genes.
Limitation of the study. The limitation of this review is the lack of domestic literary sources.
Conclusion. Further research of functional polymorphisms of the GST family genes are needed to develop effective systems for the diagnosis, prevention, and treatment of diseases.
Perlindungan Hukum Bagi Konsumen terhadap Penggunaan Vaksin Campak Rubella Berdasarkan Hukum Positif di Indonesia
Authors: Maranti Idzhom Ummy Attyyah
Published: April 2023

Campak dan Rubella merupakan penyakit infeksi menular melalui saluran nafas yang disebabkan oleh Virus Campak dan Rubella. Upaya imunisasi menjadi hal yang sangat penting dalam upaya pengendalian dan pemberantasan penyakit tersebut. Tujuan dari penelitian ini adalah untuk mengkaji perlindungan hukum bagi konsumen terhadap penggunaan vaksin campak rubella berdasarkan hukum positif di Indonesia. Metode penelitian yang diaplikasikan adalah penelitian hukum normatif dengan menggunakan pendekatan perundang-undangan dan konseptual. Hasil penelitian menunjukkan bahwa perlindungan hukum terhadap konsumen dalam pengunaan vaksin campak rubella yaitu upaya perlindungan hukum dapat diberikan melalui dua perlindungan hukum yaitu perlindungan hukum Preventif dan perlindungan hukum Represif. Perlindungan hukum Preventif yaitu perlindungan terhadap konsumen yang diselenggarakan oleh dinas kesehatan Kota Mataram yaitu dengan melakukan sosialisasi dan kampanye-kampanye vaksin MR. Sedangkan perlindungan hukum Represif yaitu upaya hukum untuk melindungi konsumen terhadap barang yang diproduksi dan diperdagangkan oleh pelaku usaha agar tidak merugikan pihak konsumen.
Viktimisasi dan Perlindungan Hukum terhadap Korban Tindak Pidana Penipuan Melalui Media Sosial
Authors: Rachmat Lail Aoelia Anjani
Published: April 2023

Penelitian ini bertujuan untuk menganalisis apa saja yang menjadi faktor-faktor viktimisasi terhadap korban penipuan melalui media sosial dan bagaimana bentuk perlindungan hukum terhadap korban penipuan melalui media sosial. Penelitian ini merupakan jenis penelitian hukum normatif dengan menggunakan pendekatan konseptual, pendekatan undang-undang, dan pendekatan kasus. Penelitian ini menemukan bahwa Pertama, faktor yang menyebabkan korban tersebut menjadi korban penipuan media sosial ialah target yang sesuai (suitable target), ketiadaan penjagaan yang memadai (absence of capable guardians) dan pelaku yang termotivasi (motivated offenders) dilihat dari status ekonomi dan aktivitas sosial dengan media digital/online yang tanpa sadar membuat diri menjadi korban kejahatan media sosial. Kedua, bentuk perlindungan korban tindak pidana penipuan dari Kitab Undang-Undang Hukum Pidana maupun Undang-Undang Nomor 19 Tahun 2016 tentang perubahan atas Undang- Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik. Perlindungan korban dapat di tempuh melalui prosedur yang telah ditentukan, OJK, KOMINFO, dan LPSK.
Kewenangan Bawaslu Kabupaten/Kota dalam Proses Penanganan Pelanggaran Kode Etik Pengawasan Pemilihan Umum Ad Hoc
Authors: Idhar Idhar , Hasanah Siti , Jiwantara Firzhal Arzhi
Published: April 2023

The authority of regency-city Bawaslu is contained in Election Supervisory Body Regulation Number 4 of 201 concerning Mechanisms for Handling Violations of the Ad Hoc Election Supervisory Committee's Code of Ethics, whereby regency-municipality Bawaslu becomes a judge in the ethical judicial process whose professional integrity must be demonstrated so that the ethical court previously conducted by DKPP is maintained as an effort to uphold democracy from deviant administrative practices.
Inovasi produk TOGA Immunomodulator dan budidayanya
Authors: Kurniawati Darini , Hidayah Nurul , Malahayati Siti
Published: April 2023

The Covid-19 pandemic has an impact on partners and they want to innovate businesses that are needed by the community, namely herbal products that can increase endurance but are more durable and can be stored. Methods with education and practice of making traditional herbal instant powder preparations by conventional means of crystallization by heating and adding granulated sugar. Jamu powder is packaged and labeled as partners. Business licensing assistance has been carried out and has sold it directly or digital marketing with Instagram and WhatsApp promotional posters. Raw material efforts are assisted by cultivating the immunomodulator TOGA in the partner's yard. Evaluation of education by conducting a pre-test and post-test with the results obtained an increase in the category of good knowledge level by 58%. Evaluation of production that sells a lot is red ginger instant powder, while TOGA cultivation thrives waiting for harvest age. Abstrak: Pandemi Covid-19 berdampak terhadap mitra dan menginginkan berinovasi usaha yang diperlukan  masyarakat yaitu produk herbal yang bisa meningkatkan daya tahan tubuh tapi lebih awet dan bisa disimpan. Metode dengan edukasi dan praktek pembuatan sediaan serbuk instan jamu tradisional dengan cara konvensional kristalisasi melalui pemanasan dan penambahan gula pasir. Serbuk jamu dikemas dan diberi label mitra. Pendampingan perijinan usaha sudah dilakukan dan sudah menjualnya secara langsung maupun marketing digital dengan poster propmosi  Instagram dan whattshap. Upaya bahan baku dibantu dengan budidaya TOGA imunomodulator di lahan pekrangan mitra. Evaluasi edukasi dengan melakukan pre-test dan post-test dengan hasil diperoleh kenaikan kategori tingkat pengetahuan baik sebesar 58%. Evaluasi produksi yang banyak terjual yaitu serbuk instan jahe merah, sedangkan budidaya TOGA tumbuh subur menunggu usia panen.
Penguatan Kewenangan Majelis Pengawas Wilayah Notaris dalam Pembinaan dan Pengawasan Notaris
Authors: Putra Guntur Ilman , Hasanah Siti , Jiwantara Firzhal Arzhi
Published: April 2023

Peranan dan kewenangan Notaris sangat penting dalam kehidupan masyarakat untukmendapatkan kepastian hukum terhadap perbuatan-perbuatan hukum yang dilakukan. Dalam menjalankan peran dan kewenangan itu, perilaku dan perbuatan yang dilakukan Notaris sangat rentan terhadap penyalahgunaan jabatan profesinya, sehingga dapat merugikan masyarakat.Untuk menghindari kerugian oleh masyarakat itu diperlukan suatu badan yang melakukan pengawasan terhadap Notaris. Dalam Penelitian ini menggunakan metode penelitian hukum normatif adalah suatu proses untuk menemukan suatu aturan hukum, prinsip-prinsip hukum maupun doktrin-doktrin hukum guna menjawab isu hukum yang dihadapi. Berdasarkan hasil penelitian Penguatan Kewenangan Majelis Pengawas Wilayah Notaris Dalam Pembinaan Dan Pengawasan Notaris adalah Majelis Pengawas Notaris mempunyai kewenangan melakukan pengawasan secara administratif dan Sanksi merupakan Akibat Hukum terhadap Putusan Majelis Pengawas terhadap Notaris yang melanggar ketentuan-ketentuan mengenai pelaksanaan tugas Jabatan Notaris sebagaimana tercantum dalam UU JABATAN NOTARIS.
Opportunities and applications of smart contracts: A vision from the business, academic and scientific literature
Authors: Guardado Rubén Trejo , Carmona Eduardo Alejandro , Verver y Vargas Herlinda Goretti López , Hernández Iván Saúl Jiménez , Martínez Norma Guadalupe Pérez , Trejo Blanca Yasmin Vázquez
Published: April 2023

Objective. In the present work, the bibliographical production referring to smart contracts is reviewed from the business, academic and scientific points of view. The aim is to analyze precisely how the relationship between smart contracts and blockchain occurs to establish a context in both developments.
Design/Methodology/Approach. The Scopus database was consulted using the keyword: "smart contract". It was decided to use the SciMAT bibliometric tool for the bibliometric study with the approach based on a joint analysis of words and the h-index to visualize diagrams and thematic areas relatively simply for two periods: 2010-2018 and 2019-2021.
Results/Discussion. It was necessary to know the concept of smart contracts for the future of contract law and the digital economy. Some institutions and people will be against considering them as authorized legal alternatives; However, due to the technological advance currently being presented, their development will only be a matter of time.
Conclusions. Smart contracts are a technological innovation that, through blockchain technology, carry out transactions safely, quickly and with almost no risk of non-compliance.
Inhibidor adquirido del factor V asociado a ceftriaxona: reporte de un caso clínico
Authors: Pastuizaca Evelyn , Santorum Carlos , Guzman Keilyn , Cermelj Monica , Scoles Graciela
Published: April 2023

Se presenta el caso de un varón de 78 años con deficiencia del factor V de la coagulación (FV) sin clínica de sangrado, adquirido tras recibir tratamiento antibiótico. La presencia del inhibidor del FV se confirmó mediante método Bethesda. La coagulopatía se corrigió con posterioridad a la suspensión del fármaco.
Tiempo de lisis del coágulo en plasma libre de plaquetas
Authors: Rodriguez Cabezas David , Hidalgo Patricia , Vera Francisco
Published: April 2023

Este ensayo modificado, permite una evaluación detallada de la capacidad de formación y degradación de la fibrina(1). Plasma libre de plaquetas (PLP) se mezcla con un activador de la coagulación, fosfolípidos y calcio para inducir la formación de fibrina. Simultáneamente se añade t-PA u otro activador del plasminógeno para inducir la lisis del coágulo. El ensayo utiliza el principio de turbidimetría para la detección, aumentando la turbidez de la muestra con la formación de fibrina y disminuyendo con su lisis. La absorbancia se registra a intervalos de tiempo continuos por un período determinado, resultando en la formación de una curva que permite la evaluación de la actividad fibrinolítica plasmática.
Rebelión mieloide
Authors: Del Castillo Mariana , Figueroa María Flavia , Pagani María , Luciardi María Gabriela , Zevallos Cecilia , Abdala Andrea Verónica , Gómez Rita Anahí , Gramajo Cecilia
Published: April 2023

Se presenta un paciente varón con diagnóstico inicial de una neoplasia mieloproliferativa Filadelfia negativa, sin respuesta al tratamiento y con empeoramiento de síntomas, por lo que se realiza nueva evaluación de enfermedad con diagnóstico de leucemia mieloide crónica coexistente. Evoluciona con anemia con requerimiento transfusional, suponiendo un reto diagnóstico y terapéutico para el equipo tratante, llevando a una nueva re evaluación del paciente y a la realización de consultas a expertos en el tema para la búsqueda de estrategias para su tratamiento. Se realiza una revisión bibliográfica del tema que se describe a continuación.
Conversational AI Chatbot for Education Institute
Authors: Shwetha G R  , Manasa S  , Modupalli Suneela  , Nisha K M  , Vandana K
Published: April 2023

Now a days everything was online and becoming easy for humans in order to get any information in the place where they are. On this note most of the websites were creating the human like chatbots in order to give the solutions for the human queries about the particular things. The chatbots are the software which provides a platform for the humans by interacting with them. Because so many peoples are not able to visit a for particular place for clarifying the doubts maybe of different reasons like long distance, no proper transportation etc…. Such kind of people can utilize the option of chatbot in there specific websites. Here we mainly discussed about the chatbot for the college website. Because most of the students will be having the lots of doubts before joining like about college ,staff, placements, transportation etc…Even though the college administration are not able to answer for all the queries which makes them burden .And it is also not practically good because so many students will visit, they cannot answer for each of them’s queries. So that we are focusing to get rid from this problem and make a easy way to know know all information about the college.
Understanding the relationship between domestic and intimate partner violence, adverse childhood experiences, and chronic opioid use disorder: The patient perspective
Authors: Thiesset, PhD, MPH Heather F. , Barber, MS Melinda , Moore Braydonn , Van Komen Amelia , Crandall, PhD AliceAnn
Published: April 2023

Introduction: Opioid dependence and misuse are a plague of epidemic proportions in our communities and globally. Prior trauma in childhood may contribute to opioid dependence, while one consequence of opioid misuse is increased risk for involvement as both perpetrators and victims in domestic and intimate partner violence (DV and IPV). The aims of this study were to understand the proportion of patients who identified as having an opioid use disorder (OUD), if OUD was associated with higher rates of DV and IPV as both perpetrators and victims, and whether adverse childhood experiences (ACEs) as well as demographic factors related to instability in their social life were higher among those with OUD compared to those without.

Methods: The sample consisted of 124 patients who were identified as having an OUD in their medical records based on ICD-10 codes. Each participant completed an anonymous survey about basic demographics, their alcohol, drug, and opioid intake, and their history of domestic and IPV. Descriptive statistics, univariate, and multivariate regression analyses were conducted in STATA 17.1 software.

Results: A sample of patients with an OUD diagnosis in their medical record found that 64 percent of patients acknowledged having a history of opioid addiction. Patients acknowledging OUD were more likely to not be married (divorced or single) (p < 0.01), younger than 50 years of age (p < 0.01), non-White (p < 0.01), and had higher average ACEs scores (p < 0.0X). Patients who reported OUD were also more likely to be both victims and perpetrators of DV/IPV compared to patients who denied OUD.

Discussion: OUD needs to be treated holistically to ensure that the adverse consequences of DV and IPV do not become a silent disease perpetuated on this population, their families, and society.
Estimating the prevalence and correlates of pain among people living with HIV who use unregulated drugs in a Canadian setting
Authors: Loh, MSc Jane , Buxton, MBBS, MHSc, FRCPC Jane , Kaida, PhD Angela , Voon, BSN, RN Pauline , Grant, BSc Cameron , Milloy, PhD M-J
Published: April 2023

Although prevalent among people living with human immunodeficiency virus (HIV) (PLWH) and people who use unregulated drugs (PWUD), pain and its possible links to substance use patterns and engagement in HIV treatment remains poorly characterized. We sought to evaluate the prevalence and correlates of pain among a cohort of PLWH who use unregulated drugs. Between December 2011 and November 2018, 709 participants were recruited, and data were analyzed using generalized linear mixed-effects (GLMM). At baseline, 374 (53 percent) individuals reported moderate-to-extreme pain in the previous 6 months. In a multivariable model, pain was significantly associated with nonmedical prescription-opioid use (adjusted odds ratio (AOR) = 1.63, 95 percent confidence interval (CI): 1.30-2.05), nonfatal overdose (AOR = 1.46, 95 percent CI: 1.11-1.93), self-managing pain (AOR = 2.25, 95 percent CI: 1.94-2.61), requesting pain medication in the previous 6 months (AOR = 2.01, 95 percent CI: 1.69-2.38), and ever being diagnosed with a mental illness (AOR = 1.47, 95 percent CI: 1.11-1.94). Establishing accessible pain management interventions that address the complex intersection of pain, drug use, and HIV-infection has potential to improve quality of life outcomes among this population.
The Laboratory Revolution and the Creation of the Modern University, 1830-1940
Authors: Berkel Klaas , Homburg Ernst
Published: April 2023

The modern research university originated in Europe in the second half of the nineteenth century, largely due to the creation and expansion of the teaching and research laboratory. The universities and the sciences underwent a laboratory revolution that fundamentally changed the nature of both. This revolutionary development began in chemistry, where Justus Liebig is credited with systematically employing his students in his ongoing research during the 1830s. Later, this development spread to other fields, including the social sciences and the humanities. The consequences for the universities were colossal. The expansion of the laboratories demanded extensive new building programs, reshaping the outlook of the university. The social structure of the university also diversified because of this laboratory expansion, while what it meant to be a scientist changed dramatically. This volume explores the spatial, social, and cultural dimensions of the rise of the modern research laboratory within universities and their consequent reshaping.
Island Kingdoms in the Making :
The New Laboratories and the
Fragmentation of Dutch Universities
c.1900
Authors: van Berkel Klaas
Published: April 2023

New laboratories not only reflect current ideas about science and science
pedagogy; they also shape ideas and behaviour. The rise of the modern
research laboratory in the second half of the nineteenth century contributed
to the emergence of a new self-image for universities in Europe. The
need to house the new laboratories often resulted in laboratories being
scattered across the city, thus fragmenting university life. Instead of a
close-knit community, the university became an archipelago of institutes,
laboratories, lecture halls, and administrative buildings, where life for
professors and students centred on their own institute rather than the
entire university. The situation in the Netherlands, where the state-funded
universities expanded tremendously around 1900, offers a key case study
of these developments.
Of Growing Significance : The Support
Staff in the Laboratories and Institutes
of Utrecht University during the
Interwar Period
Authors: Nugteren Bas
Published: April 2023

This chapter focuses on the development of support staff at Utrecht
University. It was a period of rapid growth for the university and profound
modernization of scientific practice. This was also evident in the
development of support activities and support staff. Their size grew in
absolute numbers and in proportion to scientific personnel. New positions
emerged, such as analyst or glassblower, and existing positions became
more specialized, such as technician and laboratory clerk. This development
also contributed to new forms of organization: the ‘family-like’
unit of the nineteenth century faded and was replaced by a business-like
organization. Technicians, analysts, and clerks were not part of the civitas
academica, but they became more recognized for their contributions to
research and education.
Serialized Laboratories : Laboratory
Journals and the Making of Modern
Science and Scientific Publishing,
1840s–1950s
Authors: Daling Dorien
Published: April 2023

From the 1860s to the mid-twentieth century, many academic and private
research laboratories issued their own serial publications. These ‘house
journals’ seem to have proliferated especially in the European periphery.
On the basis of a few (mainly Dutch) examples, this chapter explores the
emergence and contents of house journals, their purposes and functions,
and their place in the evolution of the scientific periodical press. It aims
to shed light on the historical importance and meaning of the genre of
laboratory journals, particularly in relation to transformations in the
nature of the university, scientific authority and scientific authorship,
knowledge communities, and the media landscape of science.
Images of the Laboratory in the
Popular Press
Authors: Vanpaemel Geert
Published: April 2023

During the Laboratory Revolution of the late nineteenth century, the
popular press was instrumental in disseminating an increasing number
of visual representations of the laboratory, which contributed to the
rising public authority of laboratory research. This chapter offers a
typology of these images, based on a sample of pictures taken from the
pages of the French journal La Nature between 1873 and 1914. It argues
that there was a shift in epistemological meaning attributed to these
representations, in which the laboratory images tended to emphasize
the dehumanized, impersonal nature of strict scientific procedures, in
opposition to but also complementary with the portrayal of the individual
genius of scientists.
The Impact of the Broad Money Supply (M2) on Economic Growth per Capita in Palestine
Authors: Razia Alaa , Omarya Mostafa
Published: April 2023

This study examines the effect of the broad money supply (M2) on the per capita economic growth in Palestine using time series data from 2000 to 2020. The study used autoregressive distributed lag model (ARDL), the cointegration approach and the error correction model to investigate the effect of money supply on gross domestic product (GDP) per capita. The model is determined by four macroeconomic variables, namely, gross domestic product (GDP) per capita, broad money supply (M2), gross fixed capital formation (GFCF), and inflation rate (INF). The results show that the money supply, the total capital formation, and the inflation rate have a positive impact on the economic growth in the short run. However, none of these variables affect the economic growth in the long term.
Ensino de Geografia e transtorno do espectro autista: proposição de material 3D
Authors: Silva Silvana De Sousa , Silva Elane Do Socorro Oliveira da
Published: April 2023

Pensar o ensino de Geografia no debate sobre a inclusão em contexto escolar do aluno com o Transtorno do Espectro Autista, constitui exercício que deve englobar as análises sobre as perspectivas para a adaptação de recursos didáticos. Dessa forma, o artigo apresenta resultados de pesquisa que possuiu como objetivo produzir recurso didático não convencional em impressora 3D, voltado para o ensino de Geografia em contextos com o TEA. A pesquisa utilizou abordagem qualitativa, mediada pelos procedimentos de levantamento e a sistematização de referencial teórico em associação com a delimitação dos temas em Geomorfologia e Cartografia, visando a elaboração dos recursos didáticos não convencionais com o uso da impressão 3D. Concluiu-se que os recursos didáticos elaborados, constituem alternativa de material para trabalho com os temas da Geografia com o aluno com TEA, utilizando elementos da ludicidade, com a oportunidade de constituição de reforçadores aos recursos didáticos utilizados em sala de aula.
As aporias do sagrado e do sublime no cinema de Andrei Tarkovski
Authors: Silva David Thyago Luiz
Published: April 2023

A contribuição deste artigo reside em uma tentativa de equacionar o problema que envolve os estudos estéticos e sua relação com o sagrado, a partir do aporte teórico de Rudolf Otto sobre o numinoso e dos cânones filosóficos da categoria do sublime,  feito Schiller e Longino, desaguando, assim, no potente cinema do diretor russo Andrei Tarkovski, especificamente, em seu filme O espelho (1975); e também por seu pensamento teórico, cuja ideia percebia nas imagens cinematográficas janelas, por assim dizer, em que o homem pode ter acesso a fruições espirituais.Apesar da dificuldade intrínseca do problema, queremos demonstrar, através de exemplos do filme, a relação fronteiriça que a obra do cineasta russo manteve entre uma experiência genuinamente estética e uma experiência que flerte com o sagrado.
Durvalumab (Imfinzi)
Authors: CADTH
Published: April 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.

The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.

This review assesses durvalumab (50 mg/mL) concentrate for solution for IV infusion, 1,500 mg in combination with chemotherapy every 3 weeks (q.3.w.), followed by 1,500 mg every 4 weeks (q.4.w.) as monotherapy until disease progression or unacceptable toxicity.

Indication: In combination with gemcitabine-based chemotherapy, for the treatment of patients with locally advanced or metastatic biliary tract cancer (BTC).
Tecnologías de detección temprana de la violencia de género en la escuela. Una revisión sistemática
Authors: Cueva Tipán Edgar Andrés , Coello Freire Gustavo Oswaldo , Rodríguez Cevallos María Verónica , Ramírez Hidalgo Dora Esperanza
Published: April 2023

El abordaje de la violencia de género en la escuela ha sido asumido desde los lineamientos de gestión, el rol del docente, los cambios de actitudes de los estudiantes, entre otros enfoques. Sin embargo, no se conoce cómo se vienen aplicando las nuevas tecnologías para su detección temprana directamente por los alumnos. El objetivo de este trabajo es realizar una revisión sistemática que permita fundamentar teóricamente temas relacionados al uso de herramientas tecnológicas en una red de vigilancia, a fin de prevenir la violencia de género desde los métodos educativos. Al amparo de considerar solo los trabajos que guardan relación con el tema sobre el enfoque STEAM en la educación, se destaca el hecho de que las publicaciones consultadas responden a los últimos cinco años. Para ello, se realizó una revisión sistemática, con el método PRISMA, en bases de datos científicas de impacto como Scielo, Scopus y EBSCO. Una vez realizado el análisis, se llegó a la conclusión que los estudios de esta metodología ayudan al desarrollo de métodos de aprendizaje, que con el empleo de las tecnologías propician la detección temprana del acoso y la violencia de género en la escuela.
Las relaciones interdisciplinarias de humanidades en la enseñanza-aprendizaje de la comprensión lectora en el preuniversitario
Authors: Hodelín Barrientos Arenniuvis , Moreira Carbonell Carlos , Cuña Quintana Bárbara  Liz
Published: April 2023

A partir de las exigencias del III Perfeccionamiento del Sistema Educacional Cubano, adquiere significatividad el establecimiento de relaciones interdisciplinarias en el área de humanidades; sin embargo, aún persisten deficiencias para su aplicación en el proceso de enseñanza-aprendizaje de la comprensión lectora en el preuniversitario, donde se requiere de la integración de contenidos en asignaturas de humanidades que se complementan en la práctica educativa. Por lo expresado se declara como objetivo elaborar un programa de preparación de profesores para el establecimiento de relaciones interdisciplinarias de humanidades en la enseñanza-aprendizaje de la comprensión lectora en el preuniversitario. Se utilizaron métodos teóricos y empíricos que permitieron sintetizar las fuentes más relevantes del tema investigado. El programa elaborado y aplicado favoreció la práctica pedagógica, a partir de la vinculación teoría y práctica interdisciplinar en las humanidades. Los resultados alcanzados demostraron que la propuesta constituye una respuesta inmediata al problema declarado, por cuanto constituye una vía didáctico-metodológica que coadyuva tanto a la calidad de la dirección como al protagonismo estudiantil en el proceso de enseñanza-aprendizaje de la comprensión lectora.
Multimedia para la preparación de los instructores de Joven Club de Computación en el trabajo con los niños Síndrome de Down
Authors: Puente Herrera Yaisnara , Moreira Carbonell Carlos
Published: April 2023

El presente trabajo aborda la enseñanza-aprendizaje de los niños Síndrome de Down; teniendo en cuenta las dificultades que presentan los instructores para potenciar su desarrollo en el Joven Club de Computación. Como objetivo se plantea elaborar una metodología para la preparación de los instructores de Joven Club de Computación en el trabajo con los niños Síndrome de Down. Se aplicaron métodos teóricos empíricos y matemáticos estadísticos, en la determinación de los referentes teóricos relacionados con la enseñanza-aprendizaje de los niños Síndrome de Down. Se asumen las concepciones de preparación didáctica y metodológica de los docentes, su concreción en el proceso docente educativo, y se elabora la propuesta como vía de solución al problema científico planteado. Se valoran los resultados obtenidos que demuestran la pertinencia de la propuesta, al evidenciar avances en la preparación metodológica que contribuyeron a la preparación de los instructores de Joven Club de Computación en el trabajo con los niños Síndrome de Down, lo que demuestra que la propuesta constituye una solución viable al problema planteado.
La gestión orientadora hacia la comprensión inferencial del discurso político
Authors: García Hinojosa Darioska , Garcia Bonnane Yamilé
Published: April 2023

La comprensión discursiva, en la actualidad, resulta una temática bastante abordada por su importancia en los procesos formativos; sin embargo, en la Escuela Provincial del Partido de Guantánamo todavía existen insuficiencias para su concreción, por lo que se requiere de una gestión orientadora que garantice la adecuada comprensión inferencial del discurso político. La investigación se plantea como objetivo ofrecer niveles de ayuda para realizar una gestión orientadora hacia la comprensión inferencial del discurso político en la Escuela del Partido. Se utilizaron métodos teóricos y empíricos, que permitieron sintetizar las fuentes más relevantes del tema investigado. Los resultados demostraron que la propuesta constituye una vía esencial, que favorece la preparación de los futuros cuadros del Partido en la provincia.
Estrategia educativa para dar tratamiento a la educación vial en el proceso de formación inicial del estudiante de la Licenciatura en Educación Preescolar
Authors: Ramírez González Yarileisys , Frómeta Griñón Imayasil , Martínez Pacheco Iliana
Published: April 2023

En los momentos actuales las universidades deben contribuir a la formación de una adecuada cultura vial en los estudiantes, mediante el aprovechamiento de las posibilidades que brinda el proceso docente-educativo, para que aprendan y desarrollen normas de conducta que les permita tener un comportamiento correcto al intervenir en la vía, y una conciencia de responsabilidad ante sus peligros; sin embargo, aún persisten insuficiencias en la preparación y acciones para que este proceso se desarrolle de forma óptima con los estudiantes, pues solo se cuenta con el programa y las orientaciones metodológicas, lo que queda a la creatividad del profesor la elaboración de acciones para lograr este propósito. Se plantea como objetivo: ofrecer una estrategia educativa para dar tratamiento a la educación vial en el proceso de formación inicial del estudiante de la Licenciatura en Educación Preescolar. Se emplearon métodos de investigación científica como el histórico-lógico, analítico-sintético e inductivo-deductivo, que permitieron sintetizar las fuentes más relevantes del tema investigado, así como el desarrollo de la propuesta para su aplicación práctica. Se ofrecen acciones diseñadas desde los componentes académico, laboral, investigativo y extensionista, que propician la identificación afectiva con ellas, y sirve como fundamento de la comprensión de actitudes, hábitos, comportamientos y conductas  responsables en la vía pública. Como resultado se demuestra que la propuesta contribuye a la formación vial al favorecer la apropiación del contenido de manera reflexiva y consciente, en una unidad entre la instrucción, la educación y el desarrollo.