bluuebunny/crossref_metadata_2025 huggingface dataset:
Treating Umbilical Granuloma with Topical Corticosteroid: A Systematic Review and Meta-analysis
Authors: Sandinirwan Indra , Leo Henry , Kahuna Hasanah , Karina Permata Putri
Published: September 2021

Background: Umbilical granuloma so far can be treated with surgery or with silver nitrate. In limited facilities such as in remote areas where the surgeon is limited, pharmacological therapy with silver nitrate or topical steroid can be given. However, treatment with silver nitrate requires medical personnel and has unfavorable adverse effects if done by improper technique. This systematic review aimed to evaluate the effectiveness of topical steroid for treating an umbilical granuloma compared to silver nitrate therapy. Method: The literature search was done using search engines including PubMed, Embase, and Google Scholar. Literature selection was performed with limitations from 2000 to 2020 to get the novelty and written in the English language with a target population of infants less than 6 months were included. To retrieve the articles, topical corticosteroids, topical steroids, and umbilical granuloma were used as keywords. Results: The findings from the included studies show similar sample characteristics. The study conducted by Brodsgaard et al. had an older mean sample age than the study of Ogawa et al. (53.4 vs 31 days). The risk of topical steroid treatment failure on an individual study conducted by Brodsgaard et al. and Ogawa et al. was 3.0 (0.33–27.23, p = 0.33) and 0.94 (0.40–2.21; p = 0.33), respectively. Overall analysis, the risk of treatment failure was 1.09 (0.49–2.43, p = 0.82), there was no difference between the two interventions. Conclusions: One of the umbilical granuloma treatment options that can be considered is topical steroids, such as clobetasol proprionate 0.05% or betamethasone valerate 0.12%. When compared to silver nitrate, topical steroids have a longer therapeutic healing time but with a better safety profile. The non-inferiority study of topical steroids to silver nitrate has not been met yet.
The level of anti-thyroperoxidase antibodies in chronic urticaria patients
Authors: Zare Armaghan Gharehaghaji , Mehrasa Fatemeh , Radmehr Afsaneh , Hashemizade Lnaz
Published: September 2021

Abstract Introduction Chronic urticaria is a skin disorder characterized by swollen pruritic plaques and papules last long at least for 6-weeks. The aim of this study is to determine the anti TPO level in patients diagnosed with chronic urticaria, resistant to conventional treatments in order to test the possibility of thyroid hormone replacement with the aim of accelerating healing process. Materials and methods In this case-control study, 63 patients with chronic urticarial and 63 controls without chronic urticarial were studied bye anti TPO measurement.Anti TPO level upper than 40 IU/ has been recognized as positive. Results The prevalence of chronic urticaria among the case group was 3.5 times higher in women rather than men. Mean age of patients who have been diagnosed with chronic urticaria was 40.52±15.12 years. Mean Time of disease period was about 21.40±3.75 months. In this study, there has been no statistically significant association between age, Sex, TSH level and anti TPO concentration in both groups. Conclusion Anti TPO level in patients with chronic urticaria was not significantly different from the control group. However, Anti-TPO levels were significantly higher in patients with longer duration of disease.
Synthesis, Anti-Inflammatory Activity and Molecular Docking Studies of 1,4,5,6-Tetrahydropyrimidine-2-Carboxamides
Authors: Horishny Volodymyr Ya. , Zadorozhnii Pavlo V. , Horishnia Ivanna V. , Matiychuk Vasyl S.
Published: September 2021

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. The widespread use of NSAIDs is associated with a number of serious side effects and complications observed for both selective and non-selective COX inhibitors. Therefore, the search for new COX inhibitors, which along with their effectiveness will have minimal side effects, is a very important and urgent task. Methods: This work studied the synthesis of new 1,4,5,6-tetrahydropyrimidine-2-carboxamides based on the reaction of 2-morpholin-4-yl-N-(het)aryl-2-thioxoacetamides with 1,3-diaminopropane. All obtained compounds were tested for anti-inflammatory activity in vitro and in silico conditions. All synthesized 1,4,5,6-tetrahydropyrimidine-2-carboxamides were tested for influence on the course of the exudative phase of the inflammatory process based on the carrageenan model of paw edema of laboratory nonlinear heterosexual white rats weighing 220-250 g, using Diclofenac as a reference. Optimization of the geometry of the studied structures and molecular docking was carried out using the ArgusLab 4.0.1 software package. Results: The target products were obtained with yields of 71-98% and easily isolated from the reaction mixture. The best anti-inflammatory activity was found in N-(4-chlorophenyl)-1,4,5,6-tetrahydropyrimidine-2-carboxamide and in N-[4-chloro-3-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydropyrimidine-2-carboxamide, suppression of the inflammatory response was 46.7 and 46.4%, respectively. The results of molecular docking with COX-1 and COX-2 enzymes were in good agreement with the experimental data, R2 ˃ 0.92 and R2 ˃ 0.83, respectively. Conclusion: The compounds under study were shown to be promising as potential anti-inflammatory agents.
Increased Expression of DNA Methyltransferase 1 and 3B Correlates with Tumor Grade in Laryngeal Squamous Cell Carcinoma
Authors: Mohammadzadeh Nooshin , Mosaffa Fatemeh , Khadivi Ehsan , Jahangiri Rosa , Jamialahmadi Khadijeh
Published: September 2021

Background: DNA methyltransferase (DNMT) enzymes, encoded by DNMT1, DNMT3A andDNMT3B genes, play a major role in the development of cancers through aberrant promotermethylation. Due to little information about the biological and clinical significance of expressionchanges of these genes in Laryngeal Squamous Cell carcinoma (LSCC), the current study wasdesigned to evaluate the contribution of DNMTs expression as potential diagnostic biomarkersin progression of LSCC. Methods: DNMT1, DNMT3A and DNMT3B expressions in tumoral and normal tissues fromthirty-three LSCC patients were evaluated by relative comparative real-time PCR, prior toany therapeutic intervention. Relationship between genes expression and clinicopathologicalfeatures were also analyzed. Results: The mRNA expression levels of all three DNMTs (DNMT1, DNMT3A and DNMT3B)were significantly elevated in LSCC tumor specimens compared to that of non-tumor tissues(P<0.0001, P=0.011 and P<0.0001, respectively). The expression of DNMT1 and DNMT3Bwas strongly associated with histopathological tumor grade. Moreover, the mRNA expressionlevels of DNMT3A were significantly correlated with laryngopharyngeal reflux. No significantrelationships existed with other clinicopathological parameters. Conclusion: Data showed that the expression levels of DNMT1, DNMT3A and DNMT3Bmarkedly increased in LSCC tissues. DNMT1 and DNMT3B were mainly overexpressed in highgrade LSCC tumors, therefore, they may have a role in LSCC progression. It seems that thesegenes may serve as diagnostic biomarkers in development of LSCC.
An Overview of Cutaneous Wounds and the Beneficial Roles of Medicinal Plants in Promoting Wound Healing
Authors: Umar Nura Muhammad , Parumasivam Thaigarajan , Toh Seok-Ming
Published: September 2021

It is undeniable that many patients worldwide suffer from various types of wounds, especially from chronic wounds. The complex and intricate process of wound healing has a severe impact on the patient's quality of life as well as causing an economic burden on healthcare institutions. Although various new therapies have become available for treating patients with acute and chronic wounds for the past decade, the available therapies are often expensive or accompanied by undesirable side effects. Hence, the discovery of a new arsenal for wound healing remains a hot topic of research. Recently, plants or herbs and their derivatives have garnered significant attention as a source of therapeutic agents to treat wounds. This is because plants provide a rich reservoir of phytochemicals that could potentially become effective and affordable therapeutic agents. Thus, the present review attempted to outline wound healing mechanisms and analysed some renowned medicinal plants with potential wound healing properties from the existing literature from various electronic databases. This review also sheds light on the plant's underlying molecular mechanisms and, wherever available, acknowledges the biologically active substances found in these plants.
Fast-dissolving Sublingual Nanofibers of Ondansetron Hydrochloride: Formulation, Physicochemical Characterization, and Clinical Evaluation on Post-cataract Surgery Patients
Authors: Kamranpour Samira , Mirzaeei Shahla , Daneshgar Farid , Najafi Farid
Published: September 2021

Objective: Ondansetron hydrochloride (OND) is an antiemetic agent belongs to the 5-HT3 receptor antagonist class administrated widely in relieving nausea and vomiting which is the most common complication occurred after surgery. This study aimed to design and evaluate the physicochemical along with clinical effects of fast-dissolving nanofiber (FDN) of OND administrated sublingually to enhance the bioavailability, effectiveness, and patient compliance compared to orally disintegrating tablets (ODT). Methods: Nanofibers were prepared by the electrospinning method, using polyvinyl alcohol and alpha-cyclodextrin as polymers and sodium saccharin as the sweetener. Physicochemical and mechanical characteristics of nanofibers were examined then the clinical evaluation was performed. Eighty patients volunteering for cataract surgery were randomly divided into two groups, one received FDN, and the other treated with ODT of OND after recovery and in case of relieving nausea. The severity of nausea was assessed using a visual analogue scale in the 6 and 24 h intervals after drug administration. The SPSS 25.0 statistical software and statistical tests were used to analyze the obtained data. Results: Nanofibers possessed a mean diameter of 159 ± 30 nm beside suitable physicochemical and mechanical characteristics. Statistical evaluations showed that both FDN and ODT formulations had an equal anti-emetic effect (P>0.05) on reducing the severity of nausea but the FDN formulation caused significantly higher levels of patients’ satisfaction (P<0.05) compared to the ODT. Conclusions: Although both formulations had an almost equal anti-emetic effect, due to the benefits of this novel formulation including rapid disintegration, the ODT can be replaced by FDN.
Historical Course of Neuropsychiatric Effects of Lemon Balm (Melissa Officinalis L.) as a Medicinal Herb
Authors: Ghazizadeh Javid , Mohammadinasab Reza , Travica Nikolaj , Sadigh-Eteghad Saeed , Torbati Mohammadali , Hamedeyazdan Sanaz , Fakhari Ali , Araj-khodaei Mostafa
Published: September 2021

Abstract Affective disorders have become prevalent and costly worldwide chronic conditions. Lemon Balm (Melissa Officinalis L.) is a medicinal plant with beneficial effects on neuropsychiatric disorders. Its potential to specifically treat conditions such as depression and anxiety has been investigated for over 20 centuries. Given the lack of a historical overview of lemon balm in mood disorders, the present review aimed to introduce the historical course of the neuro-psychiatric applications of lemon balm across the centuries. We investigated several viable medieval Arabic sources up to the 15th century, to distinguish the neuropsychiatric applications, especially anxiolytic and anti-depressive effects of lemon balm. In the early centuries, lemon balm was mainly prescribed to treat gastrointestinal disorders. Over time, physicians identified the efficient use of lemon balm in sadness, sleep disorders, anxiety, depression, epilepsy, ischemic stroke, amnesia, sciatalgia, and radicular neuropathy. Importantly, it was established that the therapeutic effects of lemon balm in the field of neuro-psychiatric diseases were emphasized by physicians during the Middle Ages. These findings have since been validated in human clinical trials. Lemon balm has also demonstrated the ability to be utilized in epilepsy, amnesia and ischemic stroke. Based on the extensive history of lemon balm in neuropsychiatry, future investigations could use this knowledge to extensively investigate the potential of lemon balm in neuropsychiatric disorders such as depression and anxiety, and possibly develop an efficient neuropsychiatric remedy.
Anti-rheumatic drugs as potential anti-inflammatory, immunomodulatory agents against COVID-19: A systematic review
Authors: Sinaei Reza , Pezeshki Sara , Asadipour Ali , Shiari Reza , Sinaei Roya , Sinaei Ali
Published: September 2021

Background: The effective responses of both innate and adaptive immunity are crucial in combating Novel-Coronavirus-2 infection. An excessive response may lead to cytokine storm, which is a challenging problem in therapeutic strategies. Methods: A systematic review was carried out by searching OVID MEDLINE, PUBMED, Google Scholar, and Cochrane library databases from inception until August 2, 2020, for anti-inflammatory and immunomodulatory drugs against coronavirus disease 2019 (COVID-19). Results: The results of the effectiveness of Hydroxychloroquine are just like a sinusoidal diagram and in a state of ambiguity. Thalidomide was effective in some cases but has not yet been proven. Low-dose Corticosteroids may be effective in the early stages of the illness as a bridge. There is no evidence of benefits or adverse outcomes for the use of non-steroidal anti-inflammatory drugs and Cyclosporine-A. In some critically ill patients, Interleukin-6 (IL-6) and IL-1 blockers and to some extent Tumor-Necrosis-Factor-α and Janus-Kinase inhibitors are useful. Finally, high-dose intravenous immunoglobulin reversed the deterioration of patients in most trials. Conclusion: One strategy behind the treatments for COVID-19 is based on breaking the cytokine storm. Although avoiding the suppression of anti-viral immunity is crucial by choosing the weaker and more selective anti-inflammatories, some strategies are kept for hyper-inflammatory situations. Scheduling of treatment is also important. Although low-dose steroids may be effective in the early stages of the illness, "Tocilizumab" is more effective in severe situations, when the IL-6 level is high and other drugs are ineffective. Therefore, consideration should be given to each patient separately.
Potential Roles of Vitamins in the Management of COVID-19: A Comprehensive Review
Authors: Rezaei Homa , Khiali Sajad , Rezaee Haleh , Bannazadeh Baghi Hossein , Pourghasem Matin , Entezari-Maleki Taher
Published: September 2021

The coronavirus disease 2019 (COVID-19) outbreak has caused a public health crisis worldwide. However, data regarding the protective factors of the disease is limited. Consequently, preventive health measures that can decrease the risk of infection, progression, and severity are dreadfully required. It is well-documented that people with immunodeficiency, such as the elderly, people who already have comorbidities (e.g., diabetes mellitus, hypertension, respiratory and cardiovascular disorders), and underrepresented minorities, are placed in a group with a higher risk of getting infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A diet rich in vitamins, minerals, and antioxidants plays an essential role in strengthening the immune system and fighting against invading pathogens. The present comprehensive review has discussed published literature regarding the potential role of vitamins in strengthening the immune system and managing viral infections, particularly SARS-CoV-2 infection. Although there are controversial data regarding the plasma level of vitamin D and the severity of the disease, according to the limited evidence, vitamin D may lower the mortality rate. Moreover, vitamin C could reduce the development of inflammatory response; however, the results of ongoing clinical trials are required to confirm these primary findings.
The Association of Kidney's GFR and Serum Creatinine Levels with Renal Scarring through 99mTc-Glucoheptonate Radiopharmaceutical Scan in Patients with Urinary Tract Infection
Authors: Fakhari Ashraf , Gharepapagh Esmaeil , Gilani Neda , Mirfakharei Nardin , Farajbakhsh Mamaghani Farzad , Dabiri Oskuei Shahram
Published: September 2021

UTI (urinary tract infection) is a leading case of renal scarring. Most of nephrons are found in kidney cortex, so it is important for early diagnosis of scarring. In this study, we investigated if scarring affects GFR (glomerular filtration rate) and serum level of creatinine through dual multipurpose 99mTc-GH (99mTc-Glucoheptonate) scintigraphy in patients with UTI. Methods: During this study 21 patients with UTI were studied by 99mTc-GH scan. For performing scintigraphy, the patient was injected by 370-555 MBq of 99mTc-GH and studied through two steps including dynamic (immediately after injection) and static (2-3h after injection) phases. The results were evaluated by appropriate analytical methods. Moreover, five patients were studied by both 99mTc-DMSA/GH (99mTc-dimercaptosuccinic acid and 99mTc-Glucoheptonate) to show 99mTc-GH scan is beneficial for detection of additional problems. Results: The results showed that there is an association between right/left kidney scarring and related GFR. Furthermore, the odds of decreased right and left kidney GFR with scarring is 12.64 and 11.89 times more than normal kidney respectively. Also, there is a significant association between renal scarring and serum level of creatinine. The study showed that the odds of increased serum level of creatinine in patients with scarring are 6.75 times more than patients without scarring. Moreover, the survey of five patients with both 99mTc-DMSA/GH scans showed 99mTc-GH could be helpful with diagnosis of some renal problems as well as scarring. Conclusion: Through this study by 99mTc-GH, it was demonstrated that kidney glomerular filtration rate and serum level of creatinine are associated with renal scarring. Furthermore, it was shown that 99mTc-GH scintigraphy could detect dilatation and abstraction of collection system in addition to renal scarring through static/dynamic renal scintigraphy.
A review of the targeting sites and biological roles of miR-4800; a novel tumor biomarker with therapeutic potential
Authors: Khordadmehr Monireh , Matin Reyhaneh , Baradaran Behzad , Baghbanzadeh Amir , Jigari-Asl Farinaz , Katiraee Farzad
Published: September 2021

MicroRNAs (miRNAs) are known as a group of short noncoding ribonucleic acids (ncRNAs). Mainly, they can manage gene expression at the posttranscriptional level in the essential biological and physiological functions. Significantly, more than 50% of the discovered miRNAs genes are placed in cancer‐related genomic regions, which can act as oncomiR or oncosuppressor. In this regard, growing evidence recently demonstrated the deregulation of miR-4800 in human cancers and non-cancerous diseases. However, little information is available on the biological roles of miR-4800 in cancer initiation, development, and progression. Here, we reviewed the targeting sites and biogenesis functions of the miR‐4800 family in physiological and pathological processes like human cancers, particularly with a particular focusing on the validated specific targets.
Selegiline alleviates the depressive-like behaviors of methamphetamine withdrawal syndrome through modulating mitochondrial function and energy hemostasis
Authors: Hosseini Mir-Jamal , Askari Sadat-Mahaleh Sima , Ghavimi Hamed
Published: September 2021

Background: Methamphetamine (METH) is considered the second most commonly abused drug in the world. There is limited or no evidence concerning the effective treatment of METH withdrawal symptoms, such as depression and anxiety. Mode of action of selegiline (increase of the brain neurotransmitter activity) suggests that it might be useful in METH withdrawal syndrome treatment, being capable of diminishing the preference and depression involved in drug degeneration and addictive activities. Methods: Mice were randomly divided into 10 groups (n= 10): five METH-nondependent groups treated with normal saline intraperitoneal (i.p) for two weeks, to which, from the 15th day, selegiline (10, 20 and 40 mg/kg; i.p) or fluoxetine (5 mg/kg; i.p) was administrated for 10 consecutive days. Other groups injected METH (2 mg/kg, at 12-h intervals) for 14 days. From the 15th day, the 10-day period of METH abstinence started and the above-mentioned doses of selegiline or fluoxetine were injected. Then, the mice were evaluated for depression and biochemical assessments from the 25th day of the study. Results: Our data indicated that post-treatment with selegiline (10-40 mg/kg; i.p) for 10 days reversed METH-induced depressive-like behaviors in the forced swimming test (FST), tail suspension test (TST), and splash test with exerting no effects on the locomotor activity. Furthermore, none of the previously proposed treatments affected the behavioral abnormality in the control animals. Moreover, both selegiline and fluoxetine as standard antidepressant drug, substantially improved the levels of mitochondrial reduced glutathione (GSH), malondialdehyde (MDA), and adenosine triphosphate (ATP). Conclusion: Our findings demonstrated that selegiline produced antidepressant-like effects following METH withdrawal and prevented the mitochondrial dysfunction in the male mice.
EZH2 knockdown upregulates expression of the genes involved in T-ALL cell differentiation
Authors: Safaei Sahar , Baradaran Behzad , Mansoori Behzad , Fardi Masoumeh , Baghbani Elham , Amini Mohammad , Hemmat Nima , Safarzadeh Elham , Abdoli Shadbad Mahdi , Shanehbandi Dariush , Solali Saeed
Published: September 2021

Background: EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), as one of the polycyclic group proteins (PcGs), is an epigenetic regulator that plays a crucial role in the pathophysiology of hematologic malignancies through regulating cell differentiation. Also, it is well known that aberrant expression of specific transcription factors can be involved in the pathogenesis of various cancers. Objective: Herein, we aimed to suppress EZH2 expression in MOLT-4 cells, T-ALL (T cell acute lymphoblastic leukemia) cell line, and evaluate the role of EZH2 on the expression of transcription factors that regulate T cell maturation, differentiation, and apoptosis. Methods: EZH2-siRNA was transfected into MOLT-4 cells, and the expression levels of EZH2, NOTCH1, TCF1, IKZF1, and NFATC1 were measured using real-time PCR. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay was performed to study the effect of EZH2 knockdown on MOLT-4 cell viability. The apoptosis rate of EZH2-siRNA transfected cells was assessed by flow cytometry. The interaction of mentioned genes was investigated using STRING and GO (gene ontology). Results: Our results have shown that EZH2-siRNA transfection can substantially decrease EZH2 expression in MOLT-4 cells. Besides, EZH2 suppression can upregulate NOTCH1, TCF1, IKZF1, and NFATC1 expression levels. EZH2 knockdown does not affect the viability and apoptosis of MOLT-4 cells. The most remarkable protein-protein interaction of EZH2 has been with NOTCH1. Besides, GO analysis has demonstrated that EZH2, NOTCH1, TCF1, IKZF1, and NFATC1 were located within nucleoplasm and can regulate RNA polymerase II-mediated transcription. Conclusion: Our results have shown that MOLT-4 cells harbor increased expression of EZH2 in comparison with normal human T cells. EZH2 knockdown can upregulate the expression of the transcription factors involved in T cell differentiation. Thus, EZH2 can halt the differentiation of immature lymphoblastic T cells.
Dynamic facial reanimation in the elderly using masseteric-to-facial nerve transfer
Authors: Sreedharan Sadhishaan , Zhou Jieyun , Pratt George
Published: September 2021

Background: Masseteric-to-facial nerve (MTF) transfer offers the advantages of primary nerve coaptation, a high density of motor axons, and the potential connectedness between facial and trigeminal central cortical centres. Despite these benefits, its use in individuals aged greater than 60 years has not been widely described.
Methods: A PubMed literature review from 1 January 1978 through to 31 December 2018 was performed to identify individuals older than 60 years who underwent a masseteric-to-facial nerve transfer. In addition, a retrospective chart review of all elderly patients who underwent a masseteric-to-facial nerve transfer at a single institution was conducted. Details on patient demographics, surgical techniques, outcomes and complications were recorded. Ethics approval for the study was obtained through the Monash Health Human Research Ethics Committee (RES-18-0000-768Q).
Results: For the literature review, 12 out of 506 articles met the study criteria, with 28 patients identified and analysed. The average time to first facial movement was 5.5 months. Average improvement on oral commissure excursion was 11 mm. Of the eleven patients included in the clinical series, 27 per cent of patients experienced postoperative complications and there were no reported mortalities.
Conclusion: Masseteric-to-facial nerve transfer is a safe and viable option for midface and perioral reanimation in the elderly with short term facial nerve palsies.
Targeted muscle reinnervation in quadruple amputees: self-reported outcomes
Authors: Rudduck Emma-Leigh , Bruscino-Raiola Frank , Angliss Margaret , Gray Steven J , Lee Gow David , Hutchinson Abby
Published: September 2021

Targeted muscle reinnervation (TMR) reduces pain and physical and psychological disabilities in amputees. We present the first two cases reported globally of quadruple amputees that underwent acute TMR. Each patient completed our novel ‘The Alfred Hospital Osteointegration Survey’ (TAHOS) for each limb at six, 12 and 24 months post amputation which evaluated aspects of prosthesis wear, neuroma-related residual limb pain (RLP), phantom limb pain (PLP) and overall function. Our findings that TMR reduced or eliminated RLP and PLP by 12 months and clinically improved prosthetic function in both quadruple amputees reflects the current literature for single and multiple limb amputees.
Johann Gottfried Wilhelm Palschau: Reconstructing the Composer's Biography
Authors: Смирнов Аскольд Владиславович , Сербин Павел Георгиевич
Published: September 2021

В статье на основе широкого ряда источников (мемуары, письма, биографические словари, научные работы и т. д.) реконструируется биография прославленного в свое время композитора и клавириста-виртуоза Иоганна Готфрида Вильгельма Пальшау (1741-1815). Подробно освещаются его концертная жизнь и композиторское творчество, а также контакты в музыкальной среде Санкт-Петербурга конца XVIII - начала XIX века. Впервые приводится список всех изданных при жизни композитора произведений.

Basing on numerous sources (memoirs, letters, biographical dictionaries, scientific works, etc.), the article reconstructs the biography of celebrated composer and virtuoso keyboardist Johann Gottfried Wilhelm Palshau (1741-1815). The little-known aspects of his concert life and his activity as a composer, as well as his contacts with other musicians in St. Petersburg of the late 18 and early 19 centuries, are covered in detail. For the first time, a list of all works published during the composer's lifetime is presented.
“Yiddish Songs” of Mieczyslaw Weinberg: Finding a Jewish Idiom
Authors: Хаздан Евгения Владимировна
Published: September 2021

Два цикла Мечислава Вайнберга с одинаковыми названиями «Еврейские песни» (op. 13 и op. 17) были написаны в 1943 и 1944 годах. В обоих сочинениях Вайнберг обратился к поэзии на идише, выбрав стихи Ицхока Лейбуша Переца и Самуила Галкина. Первый цикл дважды был опубликован при жизни композитора, однако в программах концертов и на дисках он звучал в основном на русском языке. О его содержании тоже судили по переводам. Второй цикл до недавнего времени оставался в рукописи. Циклы объединяет также обращение композитора к модусу Adonoy Molokh, в котором звучат молитвы некоторых праздничных дней - Субботы и Новолетия. Вайнберг не цитировал синагогальные песнопения, но создавал новые мелодии по тем же законам, по которым возникали их многочисленные варианты в ашкеназ-ской культуре. Музыка «толкует» текст, в некоторых случаях заставляя его переосмысливать. Одновременно композитор использует арсенал средств из европейского академического словаря и отсылает к музыке классиков.

Two cycles of Mieczystaw Weinberg with the same title “Jewish Songs” (op. 13 and op. 17) were written in 1943 and 1944. In both works, Weinberg turned to Yiddish poetry, choosing poems by Itschok Leibush Perets and Samuel Halkin. The first cycle was published twice during the composer's lifetime, but in concert programs and on CD's it sounded, mainly in Russian and was called “Children's Songs.” The second cycle remained in the manuscript until recently. These cycles are also united by the composer's use of the Adonoy Molokh modus, in which the prayers of Saturday and High Holidays are sung. Weinberg did not quote synagogal chants, but created new melodies under the same laws that gave rise to their numerous variants in Ashkenazic culture. His music “interprets” the lyrics, in some cases causing it to rethink. At the same time, the composer used techniques from European academic music and gave references to the music of the classics.
THE USE OF FIRST LANGUAGE IN ENGLISH AS FOREIGN LANGUAGE CLASSROOM
Authors: Priyastiti Iitha
Published: September 2021

Discussions of the second language (L2) pedagogy have been studied not only in the language and education fields. Experts working in the psychology field also propose theories on applied linguistics because L2 acquisitions involve external and internal processes. However, despite numerous studies on the field, it appears that an issue regarding the use of first language (L1) still creates continuous debates. Although arguments opposing the use of first L1 present compelling theories as to their rationale, they appear to overlook the context in which teaching and learning process takes place. The studies were either conducted in English as a Second Language (ESL) or English as a Foreign Language (EFL), where teachers are native speakers who do not share the same L1 with students. Considering the uniqueness in classroom contexts, this paper is not going to argue or take sides on the conflicting views on the use of L1. Instead, it attempts to acknowledge the gap of the context in language teaching used in previous studies. Using a sociocultural theory, this article will describe the beneficial use of L1 with a focus on its use by teachers in an EFL context where teachers share the same L1 with students. Keywords: first language, English as a Foreign Language, sociocultural theory
AN ANALYSIS ON INDONESIAN ELT TEXTBOOK FOR GRADE XI FROM THE PERSPECTIVE OF SLA PRINCIPLES USING LITTLEJOHN’S FRAMEWORK
Authors: Yulina Christina Atika
Published: September 2021

This paper outlines a procedure for language textbook analysis from the perspective of second language acquisition (SLA) principles using a minimally modified version of Littlejohn’s three-level framework by Guilloteaux as a preliminary procedure to textbook evaluation for selection. The aim is to analyze to what extent does Indonesian ELT textbook for grade XI reflects the universal SLA principles. The universal SLA principles used as material analysis criteria in this paper were drawn from the literature selected by Guilloteaux. This analysis revealed that the Indonesian ELT textbook by the Ministry of Education and Culture reflected SLA principles closely. Although only in-use evaluation can determine the extent to which this textbook actually supports language acquisition, the evidence suggests that the textbook is potentially supportive to English language learning.
Interval Waktu Pemeliharaan Berdasarkan Reliability Centered Maintanance (RCM) Pada Kinerja Saluran Udara Tegangan Menengah (SUTM) Perusahaan Listrik Negara
Authors: Fernando Very , Hernadewita Hernadewita , Purba Humiras Hardi
Published: September 2021

The State Electricity Company (PLN) serves all Indonesian people from Sabang to Merauke with overhead lines and cable lines. The frequency of blackouts in an area due to disturbances in the channel. PLN seeks to suppress disturbances by carrying out maintenance, namely turning it off or without being extinguished. Medium Voltage Air Lines (SUTM) are more frequent disturbances. The worst damage happened to the conductors, Jumpers, and insulators. Damage will often occur if it is not predictable. In order to find out when damage occurs, a method based on Predictive Maintenance is used, namely maintenance based on historical disturbance data statistics. Predictive Maintenance can be realized by using Reliability Centered Maintenance (RCM). From the results of RCM calculations and statistical data on one PLN unit, there is a new value for predictive maintenance time intervals, for conductors maintenance schedule must be carried out every 2 days, Jumpers every 12 days, and isolators every 16 days before serious damage occurs and widespread blackout Perusahaan Listrik Negara (PLN) melayani seluruh masyarakat Indonesia dari Sabang sampai Merauke dengan saluran udara dan saluran kabel. Frekuensi terjadi pemadaman pada suatu wilayah karena adanya gangguan pada saluran tersebut. PLN berupaya untuk menekan gangguan dengan melakukan pemeliharaan, yaitu dipadamkan atau tanpa dipadamkan. Saluran Udara Tegangan Menengah (SUTM) lebih sering terjadi gangguan. Kerusakan terparah ternyata terjadi pada konduktor, Jumper dan isolator. Kerusakan akan sering terjadi apabila tidak mampu diprediksi. Untuk dapat mengetahui kapan akan terjadi kerusakan digunakan metode berbasis Predictive Maintanance, yaitu pemeliharaan berdasarkan statistik data historis gangguan. Predictive Maintenance dapat terwujud dengan menggunakan  Relliability Centered Maintanance (RCM). Dari hasil perhitungan RCM dan data statsik pada salah satu unit PLN, maka terdapat nilai baru intuk interval waktu pemeliharaan secara predictive, untuk konduktor harus dilakukan penjadwalan pemeliharaan setiap 2 hari, Jumper setiap 12 hari, dan Isolator setiap 16 hari sebelum terjadi kerusakan yang parah dan pemadaman meluas.
Appendix and Back Cover Vol. 1 No. 1
Authors: Team Editorial
Published: September 2021

Appendix and Back Cover Vol. 1 No. 1
Tempat sampah otomatis berbasis Internet of Things dengan penyulangan hybrid PV-grid
Authors: Irvan Darmansyah Aldi , Sumardiono Arif , Alimudin Erna , Rahayu Maya
Published: September 2021

Tempat sampah otomatis adalah sebuah alat yang mempermudah seseorang dalam membuang sampah. Tutup tempat sampah yang dapat membuka dan menutup secara otomatis memiliki tujuan agar menghindari terinfeksinya bakteri pada tutup. Penumpukan sampah dapat menyebabkan bau tidak sedap hingga polusi udara. Tempat sampah otomatis di luar ruangan sangat sulit terakses listrik sehingga diperlukan penyuplai listrik portable. Penelitian ini bertujuan untuk pembuatan tempat sampah otomatis berbasis Internet of Things (IoT) menggunakan sistem hybrid PV-grid. Sistem ini menambahkan fungsi dari tempat sampah otomatis yaitu untuk memberikan notifikasi terhadap petugas kebersihan jika tempat sampah telah penuh. Sistem suplai listrik menggunakan hybrid dua penyulangan yaitu photovoltaic (PV) dan listrik konvensional (grid). Perancangan sistem kontrol tempat sampah otomatis menggunakan sensor ultrasonik, modul mikrokontroler Arduino Uno, dan modul GSM. Hasil pengujian menunjukkan pengisian baterai hingga penuh membutuhkan waktu 3,39 jam dan mengirimkan notifikasi jika sensor ultrasonik mendeteksi sampah dengan jarak 20 cm selama 5 detik. Sistem pemberitahuan notifikasi juga berhasil dikirimkan menggunakan media SMS.
Kendali TDS nutrisi hidroponik deep flow technique berbasis IoT menggunakan fuzzy logic
Authors: Sholihah Annisa Nurul , Tohir Toto , Al Tahtawi Adnan Rafi
Published: September 2021

Pada sistem hidroponik deep flow technique (DFT), setiap umur dan jenis tanaman yang ditanam memerlukan total dissolved solids (TDS) dengan satuan ppm yang berbeda serta kegagalan tanaman dalam bertumbuh dapat terjadi jika nilai TDS tidak terpantau dengan baik. Tujuan dalam penelitian ini untuk membuat sistem kendali nilai TDS dengan metode fuzzy logic agar nilai TDS sesuai dengan kondisi tanaman yang ditanam serta membuat sistem pemantau nilai TDS dengan memanfaatkan Internet of Things (IoT) agar nilai TDS dapat terpantau dengan baik. Sistem ini menggunakan nilai error dan delta error yang didapat dari selisih nilai setpoint dengan sensor TDS SKU:SEN0244 sebagai masukan fuzzy logic. Keluaran sistem berupa durasi ON dan OFF relay yang terhubung dengan pompa air 12 VDC. Nilai setpoint dan bacaan sensor akan ditampilkan pada LCD serta ditampilkan juga pada aplikasi Android Blynk dengan menggunakan module WiFi NodeMCU ESP8266 sebagai wireless. Hasil pengujian dari sistem yang dirancang yaitu sensor TDS yang digunakan memiliki rata-rata error sebesar 0,165%. Pengendalian yang dirancang mampu menghasilkan nilai integral absolute error (IAE) terkecil sebesar 1119 pada setpoint 800 ppm dan integral time absolute error (ITAE) terkecil sebesar 4200 pada setpoint 1000 ppm.
Antena mikrostrip berpolarisasi lingkaran pada daerah ultra high frequency dan super high frequency
Authors: Madhatillah Nurjanijan , Ludiyati Hepi , Sukoco Bagus Edy , Sulaeman Yaya
Published: September 2021

Beberapa tahun terakhir terjadi peningkatan penggunaan teknologi komunikasi WiFi dan teknologi komunikasi 5G. Kedua teknologi tersebut akan terus melayani kebutuhan manusia secara simultan. Oleh karena itu, sangat dibutuhkan sebuah peralatan yang mampu mengakomodasi kedua jaringan yang berada pada frekuensi kerja daerah ultra high frequency (UHF) dan super high frequency (SHF) tersebut dalam satu perangkat khususnya antena untuk meningkatkan efisiensi penggunaan perangkat. Pada makalah ini telah dilakukan perancangan dan simulasi sebuah antena yang bersifat dual-band menggunakan metode multi-patch dual-frequency antennas, serta penambahan metode truncated corner untuk menghasilkan polarisasi lingkaran. Dari hasil simulasi diperoleh bahwa antena mikrostrip dual-band dengan metode truncated corner memiliki frekuensi kerja 2,378 MHz dan 3540,8 MHz, bandwidth minimal 50 MHz, pola radiasi unidirectional, gain minimal 3 dBi, dan axial ratio mendekati 1,00.
Desain antena MIMO 2×2 patch rectangular dengan u-slot pada frekuensi 3,5 GHz
Authors: Madiawati Hanny , Rachma Maulida Aulya , Vitrasia Vitrasia
Published: September 2021

Semakin besarnya kebutuhan pengguna dalam sistem telekomunikasi di era sekarang membuat kebutuhan transmisi data pun harus semakin cepat dengan bandwidth yang lebar. Salah satu teknik yang dapat digunakan untuk menghadapi kebutuhan tersebut adalah teknik multiple input multiple output (MIMO) yang menerapkan sistem antena jamak di sisi pemancar dan penerima sehingga dapat meningkatkan kapasitas kanal agar dapat mentransmisikan data atau informasi dari beberapa antena secara bersamaan. Sistem MIMO juga memiliki keunggulan lain yaitu dapat mengatasi multipath fading. Antena ini dapat diaplikasikan pada WLAN 802.11n, sistem OFDM, serta jaringan seluler. Pada penelitian ini telah dilakukan desain antena MIMO 2×2 patch rectangular dengan u-slot yang bekerja pada frekuensi 3,5 GHz menggunakan jenis substrat Duroid5880 yang memiliki nilai permitivitas relatif 2,2. Berdasarkan simulasi, antena MIMO 2×2 dengan u-slot menghasilkan nilai koefisien isolasi sebesar -21,84 dB dan memiliki bandwidth sebesar 193,5 MHz dengan gain 5,324 dBi.
Animaciones musicales: Danza Eslava Nº.7 de Dvorak, tormenta.
Authors: de Frutos Domínguez Rocío , Galera Núñez María del Mar
Published: September 2021

Se trata de una animación realizada sobre un fragmento de la Danza Eslava no.7 en do menor op.46 de Antonin Dvorak. Se ha optado por una estética visual con elementos figurativos de la naturaleza y sus fenómenos que se emplean para resaltar la forma musical y otros parámetros sonoros y psicológicos de la obra.

En el proyecto Animaciones Musicales, a las alumnas y alumnos del grado de Educación Infantil dentro de la asignatura de Didáctica de la Música se pedía elegir libremente una pieza musical instrumental de entre 1 y 4 minutos de duración y, tras su análisis (forma, carácter, parámetros sonoros y elementos más relevantes...), realizar sobre esa base musical una creación visual de animación (empleando el programa PowToon o similar) en la que hubiera coherencia formal entre música e imagen. Se dio plena libertad en la elección de tema, estética visual, parámetros musicales representados, tipo de música... y se fomentó la originalidad en los planteamientos. Los vídeos resultantes se vieron y analizaron colectivamente en clase y también se expusieron públicamente en una pantalla de televisión ubicada en uno de los accesos a la Facultad de Ciencias de la Educación coincidiendo con la Exposición de cotidiáfonos “Se ruega tocar” en la que se mostraban trabajos también realizados por los alumnos de la misma asignatura.
Animaciones musicales: Cantinela de otro verano, de Yann Tiersen
Authors: de Frutos Domínguez Rocío , Galera Núñez María del Mar
Published: September 2021

Se trata de una animación realizada sobre un fragmento de la banda sonora de Amélie del compositor Yann Tiersen. Se ha optado por una estética visual con elementos figurativos de la naturaleza que se emplean para resaltar la forma musical y otros parámetros sonoros y psicológicos de la obra.

En el proyecto Animaciones Musicales, a las alumnas y alumnos del grado de Educación Infantil dentro de la asignatura de Didáctica de la Música se pedía elegir libremente una pieza musical instrumental de entre 1 y 4 minutos de duración y, tras su análisis (forma, carácter, parámetros sonoros y elementos más relevantes...), realizar sobre esa base musical una creación visual de animación (empleando el programa PowToon o similar) en la que hubiera coherencia formal entre música e imagen. Se dio plena libertad en la elección de tema, estética visual, parámetros musicales representados, tipo de música... y se fomentó la originalidad en los planteamientos. Los vídeos resultantes se vieron y analizaron colectivamente en clase y también se expusieron públicamente en una pantalla de televisión ubicada en uno de los accesos a la Facultad de Ciencias de la Educación coincidiendo con la Exposición de cotidiáfonos “Se ruega tocar” en la que se mostraban trabajos también realizados por los alumnos de la misma asignatura.
Animaciones musicales: mariposa.
Authors: de Frutos Domínguez Rocío , Galera Núñez María del Mar
Published: September 2021

Se trata de una animación muy sencilla con una estética visual que emplea elementos figurativos básicos para reflejar la forma musical de la pieza instrumental y su textura, empleando el icono de la mariposa para resaltar el componente más rítmico del acompañamiento musical frente a las líneas melódicas que aparecen representados con otras imágenes del mismo campo semántico (flores, insectos…).

En el proyecto Animaciones Musicales, a las alumnas y alumnos del grado de Educación Infantil dentro de la asignatura de Didáctica de la Música se pedía elegir libremente una pieza musical instrumental de entre 1 y 4 minutos de duración y, tras su análisis (forma, carácter, parámetros sonoros y elementos más relevantes...), realizar sobre esa base musical una creación visual de animación (empleando el programa PowToon o similar) en la que hubiera coherencia formal entre música e imagen. Se dio plena libertad en la elección de tema, estética visual, parámetros musicales representados, tipo de música... y se fomentó la originalidad en los planteamientos. Los vídeos resultantes se vieron y analizaron colectivamente en clase y también se expusieron públicamente en una pantalla de televisión ubicada en uno de los accesos a la Facultad de Ciencias de la Educación coincidiendo con la Exposición de cotidiáfonos “Se ruega tocar” en la que se mostraban trabajos también realizados por los alumnos de la misma asignatura.
Animaciones musicales: ballet de polluelos en sus cáscaras de la Suite "Cuadros de una Exposición", de Modest Músorgski
Authors: de Frutos Domínguez Rocío , Galera Núñez María del Mar
Published: September 2021

Se trata de una animación realizada sobre el Ballet de polluelos en sus cáscaras de la Suite “Cuadros de una Exposición” del compositor Modest Músorgski. Se ha optado por una estética visual con elementos figurativos relacionados con los polluelos en una granja que presenta coherencia con el carácter narrativo de la pieza musical, así como con su forma musical y resalta además otros parámetros sonoros y psicológicos de la obra.

En el proyecto Animaciones Musicales, a las alumnas y alumnos del grado de Educación Infantil dentro de la asignatura de Didáctica de la Música se pedía elegir libremente una pieza musical instrumental de entre 1 y 4 minutos de duración y, tras su análisis (forma, carácter, parámetros sonoros y elementos más relevantes...), realizar sobre esa base musical una creación visual de animación (empleando el programa PowToon o similar) en la que hubiera coherencia formal entre música e imagen. Se dio plena libertad en la elección de tema, estética visual, parámetros musicales representados, tipo de música... y se fomentó la originalidad en los planteamientos. Los vídeos resultantes se vieron y analizaron colectivamente en clase y también se expusieron públicamente en una pantalla de televisión ubicada en uno de los accesos a la Facultad de Ciencias de la Educación coincidiendo con la Exposición de cotidiáfonos “Se ruega tocar” en la que se mostraban trabajos también realizados por los alumnos de la misma asignatura.
Animaciones musicales: "Gymnopédie Nº.1" de Eric Satie en el espacio
Authors: de Frutos Domínguez Rocío , Galera Núñez María del Mar
Published: September 2021

Se trata de una animación realizada sobre la Gymnopédie nº 1 de Eric Satie. Se ha optado por una estética visual con elementos relacionados con el espacio exterior que presenta coherencia con la forma musical y resalta otros parámetros sonoros y psicológicos de la pieza.

En el proyecto Animaciones Musicales, a las alumnas y alumnos del grado de Educación Infantil dentro de la asignatura de Didáctica de la Música se pedía elegir libremente una pieza musical instrumental de entre 1 y 4 minutos de duración y, tras su análisis (forma, carácter, parámetros sonoros y elementos más relevantes...), realizar sobre esa base musical una creación visual de animación (empleando el programa PowToon o similar) en la que hubiera coherencia formal entre música e imagen. Se dio plena libertad en la elección de tema, estética visual, parámetros musicales representados, tipo de música... y se fomentó la originalidad en los planteamientos. Los vídeos resultantes se vieron y analizaron colectivamente en clase y también se expusieron públicamente en una pantalla de televisión ubicada en uno de los accesos a la Facultad de Ciencias de la Educación coincidiendo con la Exposición de cotidiáfonos “Se ruega tocar” en la que se mostraban trabajos también realizados por los alumnos de la misma asignatura.