bluuebunny/crossref_metadata_2025 huggingface dataset:
CHARACTERIZATION OF EXTRACTIVE COMPOSITION IN THE WOOD AND BARK OF CAJUPUTI (MELALEUCA CAJUPUTI SUBSP. CAJUPUTI POWELL.) GROWN IN GUNUNGKIDUL, INDONESIA
Authors: ARISANDI RIZKI , JIHAD AQMAL NUR , PALEVA ALMAAS HUKMA SHABIYYA , KURNIAWAN FAJAR ARIEF , LUKMANDARU GANIS , KARTIKAWATI NOOR KHOMSAH , RIMBAWANTO ANTO , SUNARTI SRI , HERAWAN TONI , HARYJANTO LILIEK , PUTRI ASRI INSIANA , LESTARI FAJAR , NIRSATMANTO ARIF
Published: April 2024

The aim of this study was to analyze the extractive composition of the wood and bark of cajuput (M. cajuputi subsp. cajuputi) to consider the end use material according to the characteristics of the its extractives. Results showed that the extractives properties of M. cajuputi, i.e. the contents of n-hexane, methanol, hot water extractives and total phenolic content (TPC), flavonoid content (TFC) and total polysaccharides (TSP) were 0.84 to 1.05%, 1.00 to 1.03% and 1.43 to 1.46%, and 19.2 to 38.7 and 23.2 to 27.3 mg GAE/g dried extract, 11.8 to 16.0 and 7.55 to 14.0 mg QE/g dried extract and 79.3 to 102.8 and 148.8 to 165.9 mg Glu/g dried extract, respectively. Bark had higher extractive levels than wood. In addition, TPC and TSP in the bark were greater than in the wood parts, whereas the reverse trend was found in TFC. The relatively high contents of TPC and TFC in the wood and bark suggest that their potential antioxidant properties. Based on the GC-MS analysis, the high content of sterols-steroids (31.4%) and triterpenoids (21.9%) in the bark part will have potential in the field of pharmacology.
EVALUATION OF SELECTED MECHANICAL AND PHYSICAL PROPERTIES OF PARTICLEBOARDS CONTAINING WASTE PLASTICS
Authors: MANCEL VLADIMÍR , KRILEK JOZEF , ČABALOVÁ IVETA , RÉH ROMAN , OSVALDOVÁ MÁRIA , DARABOŠOVÁ ANNA
Published: April 2024

This article is focused on the research of particleboards (PB) composed of wood particles from spruce logs and recycled crushed plastic granulates. Crushed plastic granulates sized from 1.0 to 4.0 mm were obtained from worn automobiles by recycling, specifically painted and unpainted bumpers. The proportion of plastic granulate in the particleboards represented 10%, 15%, and 20% of the total weight of the composites. In the production of PB, urea-formaldehyde resin and paraffin emulsion were used as a binder and ammonium nitrate was used as a hardener. The aim of the article was to compare the selected properties of PB containing plastic filler with pure PB. Mechanical properties (tensile and bending strength), and physical properties (water absorption and thickness swelling) were evaluated according to EN 319, EN 310 and EN 317. Based on the results, it can be stated that the bending strength and physical properties of PB containing plastic filler were significantly better compared to pure PB. On the contrary, the tensile strength values were lower in most cases.
Cirugía Plástica: Tumor Palpebral Izquierdo. Reporte de Caso
Authors: Maldonado Samaniego Edgar Leonardo , Anagallo Ruano Cristian Daniel , Vivanco Vega María Isabel , García Bonilla Hans Alessandro , Torres Andrade Víctor Oswaldo
Published: April 2024

Hasta el 85% de los tumores de párpados son lesiones benignas. Los tumores de párpados son motivo de consulta diaria en los servicios de oculoplástica. El tratamiento más común para los tumores benignos de párpados es la extirpación quirúrgica. Sin embargo, la cirugía de párpados no siempre está exenta de complicaciones. A veces pueden ocurrir complicaciones como desviación del párpado, defectos del párpado y cicatrices de contractura. El tratamiento por la cirugía es la principal opción, aunque existen otros métodos como laser, lo que resulta especialmente relevante en casos con indicaciones estéticas, como lesiones palpebrales benignas. Además, puede ser una opción para pacientes con múltiples enfermedades sistémicas o malas condiciones físicas, ya que evita el uso de métodos quirúrgicos tradicionales. Se presenta una paciente femenina con presencia de tumoración en parpado izquierdo con evolución de 6 meses de evolución la misma que dificulta la visualización.
La Deconstrucción como Técnica Metodológica Auxiliar de la Hermenéutica en los Estudios Históricos
Authors: Urquiza Cepeda Cinthia Alejandra
Published: April 2024

Se asume frecuentemente que la investigación documental-histórica se vale de la interpretación del investigador, pero se omite cuán importante es interpretar con la metodología adeucada. El resultado de este análisis mostrará la relación íntima y necesaria que hay entre la deconstrucción de Jacques Derridá y la hermenéutica de Hans-Georg Gadamer, ésta última como método per se, puede hacer su función independiente, pero la deconstrucción es como un nutriente, que abona a la interpretación y comprensión, dado que solo se pueden aplicar en el paradigma interpretativo, bajo el supuesto de que no son opuestas, porque la hermenéutica es método y la deconstrucción es técnica. El artículo se propone en tres partes, la primera y segunda tratarán sobre la conceptualización de la hermenéutica y deconstrucción y la tercera sobre cómo esta última se convierte en una técnica auxiliar en los estudios históricos.
Pengaruh Latihan Kekuatan Otot Lengan terhadap Ketepatan Smash dalam Permainan Bola Voli SMAN 1 Wonosari
Authors: Bokingo Al Iman , Mile Sarjan , Amri Muhammad Faisal Lutfi , Pakaya Rosbin
Published: April 2024

Penelitian ini terdiri dari dua variabel yaitu variabel bebas dan variable terikat. Variabel bebas adalah Latihan kekuatan otot lengan ( Push up)  dan variabel terikat yaitu Ketepatan Smash. Instrumen penelitan mengunakan instrumen tes Ketepatan smash . Teknik pengumpulan data yaitu Pre-test, Treatment, Post test. Pre-test yaitu tes awal smash sebelum diberi perlakuan Latihan push up selama kurun waktu 2 bulan dengan frekuensi 3 kali seminggu. Post-test yaitu tes ketepatan smash setelah diberikan perlakuan ( treadment). Teknik analisa data adalah dengan menggunakan rumus Uji t pada taraf signifikan a=0,05 dalam analisa data pengujian hipotesa, diperoleh t tabel senilai 1.76 sesuai kriteria pengujian bahwa terima Ho jika t hitung sama atau lebih kecil dari ttabel. Sedangkan tolak Ho jika thitung lebih besar dari ttabel. Oleh karena itu thitung 17,64 lebih besar dari t tabel (1,76), maka analisis menunjukan tolak Ho yang berarti terima Ha atau terima hipotesis penelitian. Dengan demikian disimpulkan analisa adalah terdapat pengaruh latihan kekuatan otot lengan terhadap ketepatan smash dalam permainan bola voli di Sma N 1 Wonosari.
Resultados obstétricos y perinatales tras la muerte fetal de un solo gemelo en un embarazo monocorial biamniótico: reporte de caso y revisión bibliográfica
Authors: Rodríguez Julio César , Castillo López Gerardo Edu , Resendiz Olascoaga Ana Karen , Pacheco Ruíz Sandra Ivonne , Márquez Bravo Luis Cuauhtémoc , González Macedo José
Published: April 2024

ANTECEDENTES: Las gestaciones múltiples sugieren un mayor riesgo de mortalidad perinatal. Dentro de estas estadísticas, la muerte de un solo gemelo ocurre en hasta el 6% de los embarazos múltiples. La incidencia general después de las 20 semanas de gestación (sdg) se estima entre el 2.6% y el 6.2% de todos estos embarazos. Se ha demostrado que es la coriónicidad, más que la cigosidad, la que influye en el resultado de esta complicación, debido a la angioarquitectura placentaria de las circulaciones en los embarazos monocoriónicos. Las tasas de pérdida de hasta el 30-50% se han asociado con embarazos monocoriónicos y monoamnióticos. Si ocurre antes de las 14 sdg, el embrión puede desaparecer; entre las 14 y las 20 sdg, el feto se reduce en tamaño y volumen. Y, si ocurre después de 20 sdg, el feto permanece dentro del útero hasta el final de la gestación.
CASO CLÍNICO: femenina de 18 años de edad, quien acudió a revisión obstétrica con reporte ultrasonográfico de un embarazo gemelar monocorial biamniótico de 30.4 sdg, y muerte de uno de los gemelos. Tras demostrar estabilidad hemodinámica del feto sobreviviente, así como estabilidad materna, se decidió internamiento para monitoreo estrecho. Una semana después desarrolló trabajo de parto pretérmino y se decidió la interrupción de la gestación de manera urgente. Se obtuvo un recién nacido masculino con edad gestacional sugestiva de 32 sdg, con dificultad respiratoria y requirió hospitalización para monitoreo estrecho del recién nacido prematuro. Madre egresó a las 48 horas, nunca desarrolló datos de coagulación intravascular diseminada (CID) y el recién nacido se mantuvo en hospitalización aproximadamente 3 semanas y media hasta que se egresó por adecuada adaptación. Nunca se demostró afectación neurológica o de algún otro órgano o sistema. CONCLUSIONES: Los factores más importantes al considerar el riesgo para el gemelo sobreviviente son la edad gestacional a la que ocurre la muerte del otro feto, y la corionicidad. El manejo debe incluir ecografías seriadas y programadas para el crecimiento. Estudios de Doppler arterial/venoso periférico e intracardiaco y una resonancia magnética al menos 3 semanas después de la muerte fetal para buscar cambios en el cerebro del gemelo sobreviviente. A pesar de que existen casos reportados de manejo conservador, es necesario el seguimiento estricto de datos de CID maternos, así como de desprendimiento prematuro de placenta normoinserta.
ANALISIS HIGHER ORDER THINKING SKILLS (HOTS) SISWA DALAM MENYELESAIKAN SOAL CERITA MATEMATIKA
Authors: KINTOKO  , YULIANA SARI , SUNANTI TITIS
Published: April 2024

Tujuan dari penelitian ini adalah untuk menjelaskan bagaimana siswa kelas VIII A SMPN 11 Yogyakarta memiliki kemampuan untuk menyelesaikan soal cerita matematika dengan kemampuan berpikir tingkat tinggi (HOTS) dengan materi segi empat yang terdiri dari aspek analisis, evaluasi, dan penciptaan. Penelitian kualitatif deskriptif jenis ini. Data dikumpulkan melalui wawancara dan tes tertulis. Terdapat tiga siswa dalam kelompok tinggi, sedang, dan rendah dalam penelitian ini. Hasil penelitian menunjukkan bahwa tingkat pemenuhan indikator HOTS berbeda untuk setiap kelompok siswa. Siswa di kelompok yang lebih tinggi memenuhi keenam indikator HOTS pada kedua butir soal, sedangkan siswa di kelompok yang lebih rendah memenuhi semua indikator HOTS pada butir soal nomor 1 dan memenuhi empat indikator HOTS.. Indikator yang tidak terpenuhi ialah indikator memilih metode solusi terbaik untuk menyelesaikan masalah dan indikator membuat ide, solusi/keputusan dari rancangan yang dibuat sebelumnya pada butir soal nomor 2. Siswa dari kelompok rendah hanya memenuhi 2 indikator pada setiap soal yaitu indikator menganalisa informasi yang diketahui dan ditanyakan, dan indikator membuat model matematika.
PENGARUH PERMAINAN MONOPOLI TERHADAP KEMAMPUAN OPERASI HITUNG NILAI MATA UANG PADA SISWA TUNAGRAHITA DI SLB BINA SIWI
Authors: ZULFA SAHARANI VALINDA , HIDAYAT LUQMAN
Published: April 2024

Abstrak
Penelitian bertujuan untuk mengevaluasi kemampuan operasi hitung mata uang pada siswa tunagrahita di SLB Bina Siwi. Menggunakan pendekatan kuantitatif dan metode eksperimen one grup pre-test post-test design, dilakukan penelitian yang melibatkan 6 siswa dengan tahapan pre-test, treatment, dan post-test. Pengumpulan data dilakukan melalui tes tertulis berupa pilihan ganda dan isian singkat, dengan analisis menggunakan teknik statistik nonparametris dan uji Wilcoxon Sign Rank Test. Hasil penelitian menunjukkan peningkatan signifikan pada kemampuan operasi hitung mata uang pada siswa tunagrahita setelah perlakuan, ditunjukkan dengan nilai rata-rata post-test yang lebih tinggi daripada nilai pre-test. Uji statistik menegaskan bahwa terdapat pengaruh positif dari permainan monopoli terhadap kemampuan tersebut, dengan nilai probabilitas yang signifikan secara statistik (0,027<0,05). Dengan demikian, dapat disimpulkan bahwa permainan monopoli memiliki pengaruh dalam meningkatkan kemampuan operasi hitung mata uang pada siswa tunagrahita di SLB Bina Siwi.
Influence of Stress, Discipline and Environment on Employee Performance in Emporio Architects Bali
Authors: HARUM Larassati Prasetyaning , DHARMANEGARA I.B. Agung , JAYAWARSA A.A. Ketut
Published: April 2024

Purpose:This research examines and analyzes the influence of work stress, work discipline and work environment on employee performance.Methodology:This research was conducted at Emporio Architect Bali with a sample of 57 respondents, who were taken using saturated sampling techniques. All data obtained from the distribution of the questionnaire is suitable for use. The data was then analyzed using multiple linear regression and hypothesis testing (t-test and f-test).Findings:The research results show that work stress, discipline and environment positively and significantly affect employee performance at Emporio Architect Bali. Work stress negatively and significantly affects employee performance at Emporio Architect Bali.Implication:It means that the more work stress increases, the more employee performance at Emporio Architect Bali decreases. Work discipline positively and significantly affects employee performance at Emporio Architect Bali. It means that the more work discipline increases, the more employee performance at Emporio Architect Bali will increase. The work environment positively and significantly affects employee performance at Emporio Architect Bali. It means that the better the work environment is, the more employee performance at Emporio Architect Bali will increase.
Mujeres y techo de cristal: diferencias regionales en España a través de un indicador sintético
Authors: De Castro Romero Lidia , Martín Barroso Víctor , Santero Sánchez Rosa
Published: April 2024

El objetivo del presente artículo es proponer y elaborar un índice de techo de cristal a nivel regional para España, utilizando como punto de partida el índice elaborado por la revista The Economist a partir de 2014 para medir el techo de cristal en más de veinte países de la OCDE. El indicador propuesto consiste en un índice sintético cuyo principal objetivo es servir de herramienta para comparar la presencia de techo de cristal y su evolución en el tiempo entre las distintas comunidades autónomas. De esta forma, el índice puede facilitar el diseño de políticas especíﬁcas para combatir el fenómeno.
Knowledge-Related Policy Analysis in an Inference-Enabled Actor Model
Authors: Riahi Shahrzad , Khosravi Ramtin , Ghassemi Fatemeh
Published: April 2024

People provide their information to distributed systems to receive the desired services. This information may be disclosed to the agents of the system as part of messages transmitted among them. As the agents of the system are smart, they can infer new information from their obtained information, that they may not be authorized to know. So preserving privacy in such systems is an important and yet challenging issue. We study the problem of analyzing the disclosure of private information in distributed asynchronous systems. Our approach to prevent private information disclosure is to require the system to follow knowledge-related policies defined for the system at design time. To achieve this, we construct a model of the system and assume the policies as the system properties and check whether these properties are satisfied in the system or not. In order to construct a model of the system, we extend the actor model, which is a well known reference model for distributed asynchronous systems, by enriching actors by the knowledge base and inference capability. As our knowledge-related policies should not be violated in any state of the system, we propose an efficient invariant model checking algorithm to verify the satisfaction of the policies in our actor model.
Web System to Support the Teaching of an Undergraduate Distributed Systems Course
Authors: Jaimez-González Carlos R. , Hernández-Salinas José M. , García-Mendoza Betzabet
Published: April 2024

This paper introduces a web-based system that supports the teaching of an undergraduate (UG) distributed systems course. It specifically describes a web system that was developed to complement the functionality of web objects in the XML (WOX) framework. It allows for storing and visualizing the state of distributed objects, as well as displaying and executing methods through a web interface. Users can provide values for each of the parameters. The WOX framework is essential to note as it facilitates the development of distributed applications that are object-based and can interoperate among different object-oriented programming languages. WOX employs the XML format to represent objects and uses HTTP as the communication protocol.
La figure du premier doyen de la faculté de théologie catholique de l’université française de Strasbourg
Authors: Aoun Marc
Published: April 2024

Victor Martin (1886-1945) a fortement marqué de son empreinte la vie de la faculté de théologie catholique de Strasbourg, maintenue dans l’université d’État à partir de 1923. Présidant à ses destinées en tant que doyen pendant 22 ans sans interruption, il fut surtout l’instigateur d’un modèle de mise en œuvre des relations Églises-États, dont certains fruits demeurent de nos jours. Savant reconnu, administrateur de talent et grand serviteur de l’État, il œuvra inlassablement au développement de la faculté comme lieu d’épanouissement scientifique des disciplines théologique et canonique et à son rayonnement à l’international, parvenant ainsi à faire de Strasbourg un véritable centre d’attraction pour étudiants étrangers, originaires notamment des pays de l’Europe centrale et orientale et du Proche et Moyen-Orient. Il contribua par là-même grandement à la promotion des intérêts de la France bien au-delà de ses frontières.
Gn 3, 16-19, ou la « chair-parabole »
Authors: Vivier-Muresan Anne-Sophie
Published: April 2024

Cette étude souhaite contribuer au renouvellement de nos représentations théologiques sur la création, en déployant notamment l’idée que le monde « fait sens ». Pour ce faire, nous partons de l’analyse des versets difficiles de Gn 3, 16-19, où sont prononcés les jugements divins sur l’homme et la femme après leur consommation du fruit interdit. Le texte semble résister aux différentes exégèses avancées et ne s’éclairerait, selon nous, qu’à partir d’une lecture intertextuelle avec le Nouveau Testament, dans l’horizon de l’avènement du Royaume. Une telle analyse nous mène à énoncer la notion de « chair-parabole », que nous développons à partir d’une définition de la parabole mettant l’accent sur le rapport qu’elle entretient avec l’intertextualité.
La formación del Estado docente en República Dominicana (1844-1944)
Authors: García Alberto
Published: April 2024

Reseña sobre el libro :de los Ríos, Juan B. Alfonseca Giner. (2022). La formación del Estado docente en República Dominicana (1844-1944). Editorial Universitaria Bonó.
Análise das publicações sobre a história da educação profissional na Revista Brasileira de Educação Profissional e Tecnológica
Authors: Amorim Rafaela Santos , Silva Raimundo Fábio da , Santos Fábio Alexandre Araújo dos , Nascimento José Mateus do
Published: April 2024

Este trabalho é fruto de uma pesquisa bibliográfica, do tipo Estado do Conhecimento. A análise objetivou mapear como a História da Educação Profissional vem sendo abordada nas publicações da Revista Brasileira de Educação Profissional e Tecnológica. A busca realizada na base de dados da revista obteve vinte e sete resultados. A análise dos textos realizada a partir dos resumos utilizou como metodologia a Análise de Conteúdo de Bardin (2011) e Moraes (1999). Concluiu-se que os estudos da História da Educação Profissional, apesar da baixa quantidade, contribuem para a reflexão crítica acerca das práticas almejadas pelas propostas da EPT.
Equity in Haematology
Authors: Basnayake L. S.
Published: April 2024

No abstract available
The consumption of walnuts has an impact on decreasing fasting blood glucose levels in individuals with concurrent hyperglycemia and hyperlipidemia: a randomized control trial
Authors: Sukmawati Ibu , Sirajuddin Sira , Rauf Suriani
Published: April 2024

Nationally, the prevalence of Diabetes Mellitus (DM) has increased by 0.5%. In 2013, it was approximately 1.5%, rising to 2.0% in 2018. On the other hand, it is known that administering walnut extract can reduce blood sugar levels in diabetic patients. The aim of this study is to determine the effect of walnut consumption on blood sugar levels. The research was conducted experimentally, using a pre-post test control group design. The research sample consisted of mothers with fasting blood sugar levels ≥200 mg/dL and total cholesterol levels ≥200 mg/dL (hyperglycemic and hyperlipidemic). The total sample size was 50 mothers, divided into 2 groups. Samples were selected using simple random sampling. The intervention involved giving 50 grams of walnut (Canarium Indicum L.) daily for 8 weeks to the treatment group. The research was conducted in the working area of the Paccerakang Community Health Center in Makassar City, Indonesia. Statistical analysis was performed using paired T-tests. There was a decrease in fasting blood glucose levels in the treatment group from 244.12 mg/dL to 195.52 mg/dL. In the control group, there was a slight decrease in blood sugar levels from 236.92 mg/dL to 229.96 mg/dL. Paired T-test analysis in the treatment group showed a value of p=0.00, indicating a significant difference in cholesterol levels before and after the intervention in the treatment group. In the control group, the value was p=0.07, indicating no significant difference in cholesterol levels in the control group. Administering 50 grams of walnuts per day for 8 weeks significantly lowered fasting blood sugar levels in hyperlipidemic and hyperglycemic mothers.
Brother vs Brother: The Colonial Citizen Soldier in Natal during the Anglo-Boer War and the implications for later ACF Regiments in the 1950s and early 1960s
Authors: Coghlan Mark
Published: April 2024

Daar is reeds baie geskryf oor die militére gebeurtenisse van die Anglo Boereoorlog, of die Tweede Vryheidsoorlog, veral gedurende die huidige eeufees herdenking. Die betrokkenheid van die swartes is een voorbeeld, maarhierdie referaat het te doen met die verband tussen die Engelse wit setlaars van die kolonie van Natal en dié van Hollandse afkoms, in die konteks van die reaksie van Natal administrasie tot die oodog. Dit is van belang dat vir die koloniste van veral die noordelike deel van die kolonie die Anglo Boereoorlog verskeie aspekte van 'n burgeroorlog getoon het. Virdie wit inwoners van dié distrikte was die oorlog, aangedryf deur Britse imperialisme, glad nie welkom nie. Die bitterheid van dié aspek van die sogenaamde stryd tussen "Boer en Brit" het erge gevolge gehad, spesifiek in Natal waarvandaan die Natal Carbineers afkomstig is. Dit was veral in die vroeé dekades van die Nasionale Patty regering (1948 tot ongeveer 1965) dat dit gelyk het asof die Anglo Boereoodog nog aan die gang was, en dat "Engelse" militére eenhede soos die Natal Carbineers gestrafis virhulle sonde van 'n halfeeu vantevore.
The league of nations: South Africa and the Rehoboth Basters' constitutional struggle, 1919-1939
Authors: Oosthuizen Gerhard J.J.
Published: April 2024

Die groep mense van gemengde afkoms wat gedurende die agtiende eeu in die Noordwes-Kaap hulle ontstaan gehad het, en later as die Rehoboth-Basters bekend geword het, het in 1868 die Kaapkolonie verlaat en hulle in 1870 in Rehoboth en omgewing in die gebied wat later as Duits-Suidwes-Afrika bekend was, gevestig. SuidAfrika het in 1915 Duits-Suidwes-Afrika binnegeval en verower. Suidwes-Afrika is na afloop van die Eerste Wereldoorlog as 'n C-mandaatgebied aan Suid-Afrika toegeken. Mandaathouers was onder die verpligting om C-mandaatgebiede te bestuur "...as integral portions thereof. .., but in the interest of the indigenous population" en onder jurisdiksie van die Volkebond. Hierdie verpligting is later vervat in Artikel 22 van die handves van die Volkebond en is verwys na as die sogenaamde "sacred trust". Hierdie artikel fokus op die konstitusionele stryd van die Rehoboth-Basters en die reaksie van die Suid-Afrikaanse Regering en die Volkebond in die lig van die sogenaamde "sacred trust". Baster-Suid-Afrikaanse verhoudinge is van meetafaan gf1kenmerk deurdelikate konstitusionele onderhandelinge. Die Basterraad het ondanks hewige teenstand 'n konstitusionele ooreenkoms in Augustus 1923 aanvaar. Die ontevredenes het daarop hulle eie raad verkies, waama verskeie vrugtelose versoeningspogings gevolg het. In Desember 1924 is die Suid-Afrikaanse Regering met 'n eensydige onafhanklikheidsverklaring gekonfronteer, maar in April 1925 het die Suid-Afrikaanse Regering via magsvertoon die rebelle tot oorgawe gedwing. Die gesloer met die verslag van regter J. De Villiers het groot frustrasie in Bastergeledere veroorsaak. Die rebelle het hulle male sonder tal op die Volkebond en die Goewemeur-generaal beroep, en het die hantering van die Basterkwessie uiteindelik tot konfrontasie tussen die Suid-Afrikaanse Regering en die Volkebond gelei. Die Baster Adviserende Raad wat deur die SuidAfrikaanse regering in April 1928 ingestel is, is suksesvol deur die ontevredenes geboikot. In Augustus 1932 hetdie kaptein van die ontevredenes en 'n groot aantal van sy volgelinge, gemotiveer deur die advies van die Volkebond en die ekonomiese probleme van die dertigefjare versoen met die Minderheidsparty. 'n Grotendeels verenigde Bastergemeenskap het daama tevergeefs gepoog om hulle konstitusionele posisie te verbeter. In 1939 het die Suid-Afrikaanse Geard-Allen-kommissie aanbeveel dat die Basterkonstitusie nie in daardie stadium heringestelkon word nie, aangesien die Bastersleiers onbevoeg was om die Bastergemeenskap effektief te bestuur.
Toward understanding the role of genomic repeat elements in neurodegenerative diseases
Authors: An Zhengyu , Jiang Aidi , Chen Jingqi
Published: April 2024

Neurodegenerative diseases cause great medical and economic burdens for both patients and society; however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.
Dawadawa and Kantong Additives Improve the Growth and Health of Nile Tilapia (Oreochromis niloticus)
Authors: Iddrisu Fuseini Tia , Mohammed Tofiq , Abarike Emmanuel Delwin , Ayisi Christian Larbi , Dandi Samuel Opoku , Kadiru Mohammed Wumbedow Jamal , Akongyuure Daniel Nsoh
Published: April 2024

A feeding trial was conducted to evaluate the effects of condiment on the growth and hematology of Nile tilapia (Oreochromis niloticus), stocked at 15 fish per tank with an initial average weight of 3.11±0.25 g for 8 weeks in twelve 55 m2 circular tanks. Three experimental diets, such as Dawadawa, Kantong, and Dawakan additives, and a control diet were studied in triplicate in this trial. The growth performance and feed utilization showed significant differences (p<0.05) among the dietary treatments with SGR in the additives treatment, which ranged between 3.77±0.61 and 4.31±0.09, which was higher than the control treatment (3.69±0.63). The FCR of additive diets ranged between 1.55±0.00 and 1.65±1.0 and was lower compared to the control diet (1.67±0.00). The concentrations of white blood cells, red blood cells, hematocrit, and hemoglobin (P≤0.05) observed in the control group were lower compared to the group with an enhanced additives diet showing the best blood parameters. All in all, the fish-fed Dawadawa additive showed the best growth and health among treatments. There is, however, a need for further studies to observe the effect of the condiment on a challenged fish.
Стратегии оптимального роста в стохастической модели рынка с эндогенными ценами
Authors: Zhitlukhin Mikhail Valentinovich
Published: April 2024

В работе рассмотрена стохастическая многоагентная модель финансового рынка с эндогенными ценами и найдена взвешенная стратегия всего рынка, которую конкретный агент не может обыграть асимптотически. Такая стратегия должна распределять капитал между активами пропорционально условным математическим ожиданиям дисконтированных относительных интенсивностей выплаты дивидендов. Основное предположение модели состоит в том, что все агенты малы в том смысле, что каждый из них по отдельности не оказывает влияния на цены активов. Оптимальная стратегия находится из решения некоторого линейного обратного стохастического дифференциального уравнения.
Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health
Authors: Wang Ling-Ling , Lu Zhan-Jin , Luo Shun-Kui , Li Yun , Yang Zhe , Lu Hong-Yun
Published: April 2024

BACKGROUND

Osteoporosis (OP) has become a major public health problem worldwide. Most OP treatments are based on the inhibition of bone resorption, and it is necessary to identify additional treatments aimed at enhancing osteogenesis. In the bone marrow (BM) niche, bone mesenchymal stem cells (BMSCs) are exposed to a hypoxic environment. Recently, a few studies have demonstrated that hypoxia-inducible factor 2alpha (HIF-2α) is involved in BMSC osteogenic differentiation, but the molecular mechanism involved has not been determined.

AIM

To investigate the effect of HIF-2α on the osteogenic and adipogenic differentiation of BMSCs and the hematopoietic function of hematopoietic stem cells (HSCs) in the BM niche on the progression of OP.

METHODS

Mice with BMSC-specific HIF-2α knockout (Prx1-Cre;Hif-2αfl/fl mice) were used for in vivo experiments. Bone quantification was performed on mice of two genotypes with three interventions: Bilateral ovariectomy, semilethal irradiation, and dexamethasone treatment. Moreover, the hematopoietic function of HSCs in the BM niche was compared between the two mouse genotypes. In vitro , the HIF-2α agonist roxadustat and the HIF-2α inhibitor PT2399 were used to investigate the function of HIF-2α in BMSC osteogenic and adipogenic differentiation. Finally, we investigated the effect of HIF-2α on BMSCs via treatment with the mechanistic target of rapamycin (mTOR) agonist MHY1485 and the mTOR inhibitor rapamycin.

RESULTS

The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention conditions. In vitro , Hif-2αfl/fl mouse BMSCs were cultured and treated with the HIF-2α agonist roxadustat, and after 7 d of BMSC adipogenic differentiation, the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMSCs treated with roxadustat were decreased; in addition, after 14 d of osteogenic differentiation, BMSCs treated with roxadustat exhibited increased expression of osteogenesis-related genes. The opposite effects were shown for mouse BMSCs treated with the HIF-2α inhibitor PT2399. The mTOR inhibitor rapamycin was used to confirm that HIF-2α regulated BMSC osteogenic and adipogenic differentiation by inhibiting the mTOR pathway. Consequently, there was no significant difference in the hematopoietic function of HSCs between Prx1-Cre;Hif-2αfl/fl and Hif-2αfl/fl mice.

CONCLUSION

Our study showed that inhibition of HIF-2α decreases bone mass by inhibiting the osteogenic differentiation and increasing the adipogenic differentiation of BMSCs through inhibition of mTOR signaling in the BM niche.
Klebsiella pneumoniae infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
Authors: Long Guo , Peng Peng , Peng Wei-Ting , Zhao Jie , Wan Qi-Quan
Published: April 2024

BACKGROUND

Liver transplantation (LT) is the only curative treatment for end-stage liver disease. However, LT recipients are susceptible to infection, which is the leading cause of early mortality after LT. Klebsiella pneumoniae infections (KPIs) in the bloodstream are common in LT recipients. We hypothesized that KPIs and carbapenem-resistant Klebsiella pneumoniae (CRKP) infections may affect the outcomes of LT recipients.

AIM

To assess KPI incidence, timing, distribution, drug resistance, and risk factors following LT and its association with outcomes.

METHODS

This retrospective study included 406 patients undergoing LT at The Third Xiangya Hospital of Central South University, a tertiary hospital, from January 2015 to January 2023. We investigated the risk factors for KPIs and assessed the impact of KPIs and CRKP infections on the prognosis of LT recipients using logistic regression analysis.

RESULTS

KPI incidence was 7.9% (n = 32), with lung/thoracic cavity the most frequent site of infection; the median time from LT to KPI onset was 7.5 d. Of 44 Klebsiella pneumoniae isolates, 43 (97.7%) and 34 (77.3%) were susceptible to polymyxin B or ceftazidime/avibactam and tigecycline, respectively; > 70% were resistant to piperacillin/ tazobactam, ceftazidime, cefepime, aztreonam, meropenem, and levofloxacin. Female sex [odds ratio (OR) = 2.827, 95% confidence interval (CI): 1.256-6.364; P = 0.012], pre-LT diabetes (OR = 2.794, 95%CI: 1.070-7.294; P = 0.036), day 1 post-LT alanine aminotransferase (ALT) levels ≥ 1500 U/L (OR = 3.645, 95%CI: 1.671-7.950; P = 0.001), and post-LT urethral catheter duration over 4 d (OR = 2.266, 95%CI: 1.016-5.054; P = 0.046) were risk factors for KPI. CRKP infections, but not KPIs, were risk factors for 6-month all-cause mortality post-LT.

CONCLUSION

KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.
Relative carcinogenicity of tacrolimus vs mycophenolate after solid organ transplantation and its implications for liver transplant care
Authors: Liu Dorothy , Youssef Mark M , Grace Josephine A , Sinclair Marie
Published: April 2024

BACKGROUND

De novo malignancy is a leading cause of late morbidity and mortality in liver transplant recipients. Cumulative immunosuppression has been shown to contribute to post-transplant malignancy (PTM) risk. There is emerging evidence on the differential carcinogenic risk profile of individual immunosuppressive drugs, independent of the net effect of immunosuppression. Calcineurin inhibitors such as tacrolimus may promote tumourigenesis, whereas mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, may limit tumour progression. Liver transplantation (LT) is relatively unique among solid organ transplantation in that immunosuppression monotherapy with either tacrolimus or MPA is often achievable, which makes careful consideration of the risk-benefit profile of these immunosuppression agents particularly relevant for this cohort. However, there is limited clinical data on this subject in both LT and other solid organ transplant recipients.

AIM

To investigate the relative carcinogenicity of tacrolimus and MPA in solid organ transplantation.

METHODS

A literature search was conducted using MEDLINE and Embase databases using the key terms “solid organ transplantation”, “tacrolimus”, “mycophenolic acid”, and “carcinogenicity”, in order to identify relevant articles published in English between 1st January 2002 to 11th August 2022. Related terms, synonyms and explosion of MeSH terms, Boolean operators and truncations were also utilised in the search. Reference lists of retrieved articles were also reviewed to identify any additional articles. Excluding duplicates, abstracts from 1230 records were screened by a single reviewer, whereby 31 records were reviewed in detail. Full-text articles were assessed for eligibility based on pre-specified inclusion and exclusion criteria.

RESULTS

A total of 6 studies were included in this review. All studies were large population registries or cohort studies, which varied in transplant era, type of organ transplanted and immunosuppression protocol used. Overall, there was no clear difference demonstrated between tacrolimus and MPA in de novo PTM risk following solid organ transplantation. Furthermore, no study provided a direct comparison of carcinogenic risk between tacrolimus and MPA monotherapy in solid organ transplantation recipients.

CONCLUSION

The contrasting carcinogenic risk profiles of tacrolimus and MPA demonstrated in previous experimental studies, and its application in solid organ transplantation, is yet to be confirmed in clinical studies. Thus, the optimal choice of immunosuppression drug to use as maintenance monotherapy in LT recipients is not supported by a strong evidence base and remains unclear.
Off-Road Self-Propelled Work Machines Operator Enclosure Environment Part 1: Terms and Definitions
Authors:   HFTC6, Operator Accommodation
Published: April 2024

SAE J3078 provides test methods and criteria for the evaluation of the operator enclosure environment in earth-moving machinery as defined in ISO 6165. SAE J3078/1 gives the terms and definitions which are used in other parts of SAE J3078. It is applicable to Off-Road Self-Propelled Work Machines as defined in SAE J1116 and tractors and machinery for agriculture and forestry as defined in ANSI/ASAE S390.
Nutritional and Molecular Studies of Alkaliphilic Tolerant Potential Amylase Producing Lactic Acid Bacteria Isolated from Indigenous Foods and Dumpsites
Authors: Awofe Akinyele Hafiz , Aboomo Okuku Mercy , Ifeanyichukwu Nwokeoma Cheryl , Tunde Aliu Kamoru
Published: April 2024

Alkaliphilic organisms are important in industries but most of these organisms are obtained from Bacillus species and the like that  require special scrutiny before use in fermentation of food related products. Lactic acid bacteria are generally regarded as safe (GRAS)  and are therefore readily applied in industrial fermentation with confidence. Due to high demand for the products of alkaliphilic organisms and industrial acceptability of lactic acid bacteria, there is a need to source for GRAS microorganisms that can withstand pH  ranges. The aim of this study was to isolate alkaliphilic tolerant lactic acid bacteria from fermented cassava mash, `ogi` and dump site  samples with a view to determining their nutritional requirement as well as molecular identity. Lactic acid bacteria were isolated from the  samples using standard methods. The isolates were subsequently characterized morphologically, biochemically and molecularly. Effects  of different carbon, nitrogen sources, initial temperature and pH as well as metal ions (Na+, Ca2+, Mg2+, Zn2+ and Cu2+) on the growth of  the isolates were examined. Data obtained were analyzed using one-way analysis of variance (ANOVA). Results obtained indicate that  extracted DNA sequence of A3, A7, A8 and A10 were related to those of Lactobacillus brevis FJ476121.1, Pediococcus acidilactici  CP096031.1, Pediococcus pentasaceus AB362605.1 and Pediococcus acidilactici CP053421.1 respectively with the sequences within the GenBank. 1% fructose elicited growth for all the bacteria detected except Lactobacillus brevis and ammonium nitrate was most preferred  by all the bacteria detected apart from Pediococcus pentasaceus strain. Lactobacillus brevis FJ476121.1 and Pediococcus acidilactici  CP053421.1 were the most alkaliphilic tolerant bacteria detected with OD of 0.285±0.04 and 0.198±0.04 respectively. Different metal ions  significantly influenced the growth of isolates in this study. The results in this study indicate potential applicability of the detected  bacteria for industrial processes.
Evaluation of Heavy Metals in Roadside Soil of Tumfure Main Market, Gombe State
Authors: Magaji Buhari , Kalu Kalu M. , Edwin Jirina Jennipher
Published: April 2024

Heavy metal pollution has been a problem of concern in soil ecology in recent decades. This study evaluated the physico-chemical  characteristics and heavy metal contents in roadside soil samples of Tumfure main market, Gombe, Nigeria. The soil samples were  collected from six different sampling points with a control sample each by handpicking, this was followed by oven-drying, ground to fine grain, and then sieved using a 2 mm mesh sieve. The pH, electrical conductivity and bulk density were carried out on the soil samples,  sieve and sedimentation method were used to determine the soil texture. The soil samples were weighed and digested using mixture of  HCl and HNO3. The contents (mg/kg) of four metals (cadmium, copper, lead and zinc) were estimated using Atomic Absorption Spectrophotometer (AAS). Among the metals analyzed, the contents of Cd, Cu and Pb were not detected while the content of Zn (23.454 -  36.026) was found to be within the desirable permissible limits by the World Health Organization (WHO) and European Regulatory  Standards (EURS) whose prevalence is to be considered non-toxic in unpolluted soils.
PCR Detection of Extended Spectrum β-Lactamase from Some Gram Negative Bacteria of Clinical Source
Authors: Ishola A.D. , Ishola L.T. , Lawal R.T
Published: April 2024

Beta-lactamase-producing microorganisms present distinct challenges in health care systems around the world as a result of the  extensive utilization of broad-spectrum antibiotics. The objective of this research endeavor was to ascertain the antibiotic resistance  profile and presence of β-lactamase genes in Gram-negative bacteria that had been previously identified and collected from laboratory  work benches at the Department of Microbiology and Parasitology, UCH, located in Ibadan, South-West Nigeria. The Kirby-Bauer disc  diffusion method was used to assess antibiotic susceptibility on all the isolates, and the double disc synergy test was used to validate  extended spectrum beta-lactamase (ESBL) production phenotypically. The PCR techniques were used to detect β-lactamase genes. The  sample distribution of the forty clinical isolates were collected from the work benches and the distribution was: urine (17), blood (9),  wound (6), sputum (4), amniotic fluid (3) and tracheal aspirate (1). Klebsiella pneumoniae was the most prevalent organism with 17  isolates ( 42.5% ). Out of the 40 isolates that were obtained, 21 were ESBL producers and the distribution was as follows: Klebsiella  pneumoniae (9), Escherichia coli (6), Enterobacter cloacae (2), Enterobacter aerogenes (1), Pseudomonas aeruginosa (1), Acinetobacter  baumannii (1) and Hafnia alvei (1). The majority of the clinical isolates showed considerable resistance to antibiotic classes that were  tested, with amoxicillin-clavulanate showing the highest resistance rate at 65%. Out of all the ESBL producers, 35.3% had blaTEM, 29.4%  had blaCTX-M, 23.5% had blaSHV, and 11.8% had blaCMY. AmpC β-lactamases, Antibiotic resistance, Disc diffusion, Gram-negative  bacteria, Polymerase chain reaction.
Software Engineering in Nigeria: Trends and Challenges
Authors: Anas Abdullahi , Labaran Aminu , Bakale Muhammad Abullahi , Aliyu Bashar , Ainu Halimatu Abubakar , Bena AbdulAzeez Abdullahi , Jimada Yusuf Umar
Published: April 2024

Bringing theory and practice together is aspiration of software engineering education, so that the learner may acquire a deep  understanding on basic concepts and principles, along with skills and competences to solve real-world problems. Thus, it is not just an  academic concern about teaching relevant topics, but also a task to shape skilled individuals equipped for the industry demand.  Moreover, due to the rapid development the software industry is and transnational nature, several challenges are challenging the  qualification of software engineers, capable to develop products according to the international standards into markets overseas. Agile  software development methods are the generally used and prominent software development methods. Agile methods are simple, easy  and deliver software faster than the traditional software development methods. Software development in Nigeria is at developing stage.
The Influence of Location on the Nutritional Composition of the Rind of Watermelon (C. lanatus) in Parts of Selected Geographical Zones in Nigeria
Authors: Akporido Ufuomaroghene Esther , Okoro Israel Oghenevwodoko
Published: April 2024

Watermelon (C.lanatus)), which was formerly only grown in the Northern part of Nigeria, is now grown in Southern parts also. It is known  that weather patterns and soil composition vary as we move from the northern to the southern parts of Nigeria. However, there  is little to no data demonstrating how C.lanatus' nutritional composition is influenced by its geographic location. This study therefore sought to assess the nutritional composition of the rind of C.lanatus produced in parts of four states that corresponded to four  geopolitical areas of Nigeria. Samples of C. lanatus were gathered from four geopolitical zones of Nigeria which include; North-East,  South-West, South-East, and SouthSouth. Fruits were cleaned before the rind was removed, blended, and freeze-drying carried out. The freeze-dried samples were subjected to established methods for the determination of the amino acid profile, vitamins, proximate, and  mineral components. The results of the amino acid profile showed that distinct amino acids were present in each zone, with the  southwest sample providing the highest quantities and the south-south zone providing the lowest concentrations. The rind of C. lanatus contained calcium, magnesium, potassium, sodium, iron, phosphorus, and manganese in varying amounts, and samples from the south- west and north-east having the highest concentrations of both vitamins and minerals. The results of the proximate composition  determination showed that the southwest sample had the highest (p < 0.05) percentage of moisture, protein, and ash when compared to  other zones, and that the northeast sample had a higher percentage composition of carbohydrate, ash, and fat when compared to other  zones. Thus, the C. lanatus samples' nutritional value were distributed as follows: southwest > northeast > southeast > south-south.  According to the findings, C.lanatus rind's nutritional qualities can vary depending on where it is cultivated.
Chemostratigraphy of the Cretaceous Yolde Formation in Yola Sub-Basin, Northern Benue Trough, Ne Nigeria
Authors: Rufai Ahmad Fauziyah , Nuhu K. Samaila , Maigari Abubakar Sadiq , Finthan Boniface
Published: April 2024

This research aims to determine the chemostratigraphy of the Yolde Formation. The formation has been inadequately studied  systematically in the light of chemostratigraphy. The existing works on the formation either lack representativeness in terms of the  proxies used or are subjective during their division procedures. From the field studies, five (5) samples of sandstone and shale units of  the Yolde Formation were collected. The samples were analyzed for both major and trace elements using an X-ray fluorescence machine.  The following geochemical parameters were studied; Al2O3, Al2O3/Fe2O3, KO2/Al2O3, TiO2/Al2O3, CaO, Cr, Rb/Sc, and Zr. From the studies,  six (6) chemozones were identified in the Yolde Formation. Transgressive and regressive depositional sequences were observed  with a significant sequence boundary of maximum flooding surface which is a time-significant feature. The chemostratigraphic scheme  could not only be comparable to the regional sequence stratigraphic scheme but also more objective and higher resolution. This research  gives a systematic chemostratigraphic analysis of Yolde Formation, which testifies to the feasibility and potential of the usage of  chemostratigraphy for stratigraphic development.