bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso de la inteligencia artificial en la educación universitaria
Authors: Corzo-Zavaleta Janet , Navarro-Castillo Yulissa , Ugaz-Rivero Mildher
Published: February 2025

This study aims to conduct a bibliometric analysis to investigate the current state of artificial intelligence (AI) adoption and utilization in higher education. A quantitative methodology was employed, analyzing 1476 scientific articles from renowned databases such as Scopus and Web of Science. Data was processed using the digital tools R and VOSviewer. The findings reveal an exponential growth in publications, with a growing focus on personalized learning, automated assessment, and the use of tools like ChatGPT. Significant international collaborations were identified; however, ethical challenges and the need for appropriate policies to ensure equitable and effective AI implementation in education were also highlighted. This study provides a global overview of research trends in AI in higher education, examining its applications, opportunities, and challenges for the teaching-learning process.
Prácticas sacrificiales y sufrimiento ambiental: el caso de las mujeres de Tierra Amarilla, Chile
Authors: Duarte Hidalgo Cory , García-Carmona Alfredo , Gallardo Angel Katerin , Millán Maturana Pilar Macarena , Mora Castillo Alejandra
Published: February 2025

The study seeks to identify the sacrificial practices present in the subjectivities and corporealities of women in the commune of Tierra Amarilla, Atacama region, Chile. The commune is a sacrificial zone marked by the high presence of extractive mining companies. The notion of sacrifice, worked theoretically from different authors, gives rise to the analysis of the sacrificial practices to which women resort to face the effects of sacrifice in their lives daily. In this way, qualitative research is proposed, with a narrative and exploratory approach, carried out through a case study. Based on semi-structured narrative interviews, we inquired into the sacrificial practices developed by the participants of the study. The sample consisted of women, participants of social groups and organizations. The results revealed a series of sacrificial practices, in addition to the habituation and normalization of environmental sacrifice, as well as possibilities of resistance.
Continuous Electroencephalography in Acute Liver Failure: Findings and Prognostic Value
Authors: Chen Denise Fay , Farrque Mirza , Karakis Ioannis , Gupta Navnika , Rodriguez Andres , Kandiah Prem A.
Published: February 2025

Background and Objectives:
Neurologic complications contribute significantly to morbidity and mortality in acute liver failure (ALF). However, clinical assessment of neurologic function in this population is often challenging. Continuous electroencephalography (cEEG) is a low-risk, noninvasive diagnostic tool which can monitor real-time cerebral function. We aimed to investigate cEEG findings and prognostic significance of specific EEG features in a cohort of strictly defined ALF patients.
Methods: This was a retrospective, single-center study of adult patients with ALF who underwent cEEG monitoring for at least 6 hours between 2013 and 2022. Clinical, laboratory, imaging, and treatment characteristics were evaluated. cEEG variables included background continuity, background frequency, the presence of sporadic epileptiform discharges, rhythmic or periodic patterns, and electrographic or electroclinical seizures. The primary outcome was mortality or transition to end-of-life care during the index admission.
Results: A total of 32 patients with ALF were included. 56.3% of patients had rhythmic or periodic patterns, of which the majority were generalized periodic discharges (GPDs, 37.5%). 12.5% of patients had sporadic epileptiform discharges and 6.3% of patients demonstrated electrographic or clinical seizures. Eighteen (56.3%) patients died or were transitioned to end-of-life care during the index admission. Worsening background continuity or frequency over the course of the cEEG recording was significantly associated with poor outcome (p=0.001, p = 0.007, respectively), with a 100% mortality rate in patients demonstrating these EEG trends. A worst recorded continuity of suppression, attenuation, burst-suppression, and burst-suppression, was also associated with poor outcome (p=0.012). The presence of rhythmic or periodic patterns, sporadic epileptiform discharges, or seizures was not predictive of outcome.
Conclusions: Worsening cEEG background continuity or frequency is associated with poor outcome in adults with ALF. cEEG may contribute useful prognostic information in these patients, in conjunction with other laboratory and clinical markers of disease severity.
Self-Assembled DNA Nanocarriers for Treating Bone Fracture and Surgery-related MRSA Infection
Authors: Huang Jiaqi , Chakraborty Aishik , Shamiya Yasmeen , Luo Wei , Zahid Alap Ali , Paul Arghya
Published: February 2025

We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating osteoporosis and related Methicillin-resistant Staphylococcus aureus (MRSA) infection in bone surgery. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility on blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy in regulating bone remodeling while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. This nanomedicine may potentially enhance the therapeutic effect of zoledronic acid in treating osteoporosis and overcoming antibiotic resistance.
The Impact of Different Inspired Oxygen Concentrations Combined with Nebulized Prostaglandin E1 on Oxygenation in Patients Undergoing One- Lung Ventilation
Authors: Xing Lingxi , Halisa Paerhati , Ding Yuyan , Zhou Yihu , chang Jiaqi , Gu Xiaolan , Gu Lianbing
Published: February 2025

Background: One-lung ventilation (OLV) requires a high inspired oxygen concentration (FiO2) to promote oxygenation improvement, yet it increases the risk of postoperative pulmonary complications. Therefore, this study aimed to investigate the effects of prostaglandin E1 (PGE1) in reducing FiO2 during general anesthesia and mechanical ventilation on oxygenation and postoperative complications in patients undergoing OLV.
Method: A total of 120 patients scheduled for elective left thoracotomy esophageal cancer surgery were randomly divided into four groups (n = 30): Group L (FiO2 = 0.4, PGE1 = 0.1μg /kg), Group M (FiO2 = 0.5, PGE1 = 0.1μg /kg), Group H (FiO2 = 0.6, PGE1 = 0.1μg /kg), and Group C (FiO2 = 0.4, normal saline solution). The primary outcome was oxygenation during OLV. Secondary outcomes included intrapulmonary shunt (Qs/Qt), incidence of postoperative pulmonary complications, and changes in inflammatory cytokines.
Results: Group H exhibited higher PaO2 values than Groups L, M, and C at all time points T1-T6. Group M also showed higher PaO2 values than Groups L and C at all time points T1-T6. In contrast, Group L demonstrated significantly higher PaO2 values than Group C at time points T2-T4. The nebulization groups (L, M, H) had significantly higher PaO2/FiO2 than Group C at time points T2-T4. Group H had higher Qs/Qt values than Groups L, M, and C at all time points T1-T6. At time points T2-T4, Group L had significantly lower Qs/Qt values compared to both Group C and Group M, which in turn had significantly lower values than Group C. Regarding interleukin-6 (IL-6) levels, Group C was significantly higher than the nebulization groups at time points T5-T8, while Group L was significantly lower than Groups M and H at T8. In terms of tumor necrosis factor-α(TNF-α) levels, Group C was significantly higher than the nebulization groups at time points T7-T8. With respect to clinical pulmonary infection score (CPIS), Group L was significantly lower than Groups M, H, and C. There was no statistically significant difference in the overall incidence of postoperative complications probability (PPCs) among the four groups, nor were there statistically significant differences in pneumothorax, pulmonary infection, anastomotic leakage, ICU stay duration, or total hospital stay duration among the groups.
Conclusion: PGE1 demonstrates a significant advantage in reducing the incidence of hypoxemia, effectively improving oxygenation status in patients undergoing OLV with lower FiO2. Given the effects of PGE1 on oxygenation and inflammatory factors, as well as the CPIS, the results of this study suggest that a clinical regimen of 0.4 FiO2 + 0.1μg /kg PGE1 is appropriate.
Trial registration: registry: www.chictr.org.cn
registration number: ChiCTR1800018288
FIS1 alleviates neuropathic pain by inhibiting mitochondrial fragmentation
Authors: Zhu Chang-Lei , Li Shu-Jiao , Lin Zhi-Peng , Ni Zi-Wei , Tian Ke , Xia Yu-Lu , Tie Jing-Jing , Pu Xue-Yin , Huang Yun-Qiang , Wu Fei-Fei , Liu Hui , Zhang Kun-Long , Zhang Shuai , Wu You-Sheng , Tian Fei , Liu Nan-Nan , Yang Yan-Ling , Wang Ya-Yun
Published: February 2025

Although neuropathic pain leads to abnormal mitochondrial fission in neurons, it remains unclear whether inhibiting abnormal mitochondrial fission has analgesic effects. This study focused on mitochondrial fission protein 1 (FIS1) to investigate its role in spared nerve injury (SNI)-induced neuropathic pain and the underlying mitochondrial mechanisms. Using MiNA analysis, electron microscopy, mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and adenosine triphosphate (ATP) detection, we observed that mitochondrial networks in both excitatory and inhibitory neurons of the spinal dorsal horn (SDH) were disrupted in SNI mice, as demonstrated through the use of specifically constructed GAD2-MITO and vGluT2-MITO transgenic mouse models. Furthermore, down-regulating FIS1 specifically in excitatory neurons, but not inhibitory neurons, of spinal dorsal horn could exert analgesic effects, as demonstrated using vGluT2-Cre mice and GAD2-Cre mice. Third, epigallocatechin gallate (EGCG), which was capable of down-regulating FIS1 in the spinal dorsal horn, concurrently inhibited SNI-induced neuropathic pain. The above results indicate that down-regulating FIS1 in SDH can alleviate neuropathic pain by reducing mitochondrial fragmentation. In addition, down-regulating of FIS1 in excitatory neurons of the SDH can alleviate neuropathic pain by improving mitochondrial dysfunction. Our research findings suggest that FIS1 may represent a novel molecular target for the treatment of pain.
Solid-State Screening and Development of Ranolazine Polymorph under different conditions
Authors: Vaidya Sunita N. , Agrawal Surendra , Jirvankar Pranita , Chambhare Nikita , Lote Sukeshini
Published: February 2025

Purpose
The goal of the research was to see if a polymorph of RNZ may improve the medicine's permeability and water solubility.
Methods
For determination of solvents effect, pure drug (RNZ) was recrystallized from various solvents and crystals obtained were studied for IR. The effect of temperature and humidity was determined by keeping the RNZ crystals at 0oC, 40oC and 70oC for humidity at 75% RH and crystals were studied for IR for any change of RNZ polymorph were created with the solvent evaporation technique. The improved polymorph was physically and chemically characterized by using FT-IR, DSC, XRD and POM. The solubility study of crystalline forms in water and the impact of crystallization on temperature and humidity on crystalline phases was carried out.
Results
The DSC thermograms of a pure drug (RNZ) and polymorph are studied for a pure drug (RNZ), lone endothermic peak was It has been seen and is situated at 122oC. This spectrum neither showed the presence of water of crystallization nor any indication of glass transition. DSC thermogram of polymorph which was recrystallized from ethanol, exhibited a single endothermic peak at 137oC. According to the XRD study, the diffraction lines of a pure drug (RNZ) were matching with the polymorph. The solvents used for the purification of RNZ exhibited differences in the crystal lattice as supported by FT-IR.
Conclusion
The solvents used for the purification of RNZ exhibited differences in the crystal lattice. It was interesting to investigate the factors affecting RNZ polymorphic transformation. The transformation was noted at RH = 75% (± 5) for form II while both the formed showed stability at different temperatures.
Temporal patterns and variations of depression related health information seeking behaviour – a longitudinal analysis of Google search data
Authors: Mohammadi Nafiseh , Danielson Jonas , Espinosa-Leal Leonardo
Published: February 2025

The current research work represents the result of analyzing online health information-seeking behavior regarding depression over ten years 2013–2022 in Finland, finding the rhythms and fluctuations on different time-scales. Our paper analyzes diurnal, weekly, and seasonal patterns in six Google-suggested depression-related search queries by relying on data provided by Google Trends and the Google Health Trends Application Programming Interface-GHT-API. Our results reveal that search volumes follows temporal patterns on daily, weekly, and seasonal levels. We observe a periodical robust diurnal pattern with a significant nightly peak. Weekly patterns highlight increased search activity during weekends, with the exception of the term "Masennus"(eng. depression) which exhibits unique dynamics during weekdays. Seasonal patterns take the shape of bimodal curves for "masennus" and "masennustesti" with a peak in search interest during spring and autumn and deep during summer. These findings bear implications for healthcare providers and policy makers in pursuit of the best mental health care. Driving forces for such temporal patterns may provide the basis for further research, thus giving more depth to our understanding of online information seeking in mental health contexts.
Development and Assessment of Boron, Cerium, and Silver Ternary-Doped Titanium Dioxide Photocatalysts for the UV-A Degradation of Ciprofloxacin Antibiotic
Authors: Mishra Yash , Mahalingam Hari
Published: February 2025

Due to the development of antimicrobial resistance, the continued presence of antibiotic residues in freshwater sources is a growing global concern and hence, it is necessary to degrade the antibiotics present in the polluted waters. In this study, three different boron, cerium, and silver ternary-doped TiO2 photocatalysts with specific compositions were synthesized using the eco-friendly EDTA citrate method. The specific compositions investigated here are B1Ce0.1Ag0.06TiO2, B1Ce1Ag0.06TiO2, and B1Ce1Ag0.1TiO2. From DLS analysis, the particle size of the synthesized catalysts was found to be in the range of 125–500 nm. The XRD spectra confirmed the presence of cerium. The DRS analysis showed the bandgap energy of the synthesized catalysts to be in the range of 2.7–2.8 eV. ICP-OES analysis was done to check the leaching of the dopants from the catalysts into the solution and the results showed that silver did not leach out while boron (~ 0.2 ppm) and cerium (~ 0.1 ppm) were present in trace amounts. The catalysts were also evaluated for the degradation of ciprofloxacin antibiotic under UV-A light. At optimized conditions, the best performing photocatalyst namely, B1Ce1Ag0.1TiO2, showed ~ 54% degradation of the antibiotic in 120 min. This is attributed to the increased amounts of cerium and silver. Although the performance under UV-A irradiation is not encouraging, these results suggest that these catalysts may be more effective under visible or solar light and further work is needed to check the effectiveness under visible light irradiation as well as on larger scales of treatment.
Performance of clinical prediction models for chronic kidney disease among people with diabetes: External validation using the Canadian Primary Care Sentinel Surveillance Network (CPCSSN)
Authors: Black Jason E. , Campbell David JT. , Ronksley Paul E. , McBrien Kerry A. , Williamson Tyler S.
Published: February 2025

Background
Several clinical prediction models that predict the risk of chronic kidney disease (CKD) in people with diabetes have been developed; however, these models lack external validation demonstrating accurate predictions in Canadian primary care. We externally validated existing clinical prediction models for CKD in Canadian primary care data, overall and across subgroups defined by sex/gender, age, comorbidities, and neighbourhood-level deprivation.
Methods
We conducted a retrospective cohort study using data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) electronic medical record database (2014–2019). We identified models that use demographic, health behaviour, clinical and diabetes-related characteristics to predict incident CKD based on two recent systematic reviews and included models with sufficient predictors in CPCSSN (≤1 unavailable) and eGFR-based CKD definitions. We included adult patients (18+) with diabetes without an existing diagnosis of CKD. We identified incident cases of CKD within 5 years based on ≥2 laboratory values corresponding to eGFR < 60 mL/min/1.73 m2 separated by ≥90 days and ≤1 year. For each model, we estimated the discrimination, precision, recall, and calibration within CPCSSN.
Results
Among 37,604 patients with diabetes, 14.6% met diagnostic criteria for CKD within 5 years. Overall performance of the 13 included CKD prediction models in CPCCSN was mixed: three models displayed moderate to strong discrimination (areas under the receiver-operating characteristic curves [AUROCs] > 0.70), whereas other AUROCs were as low as 0.508. After model updating, calibrations were heterogeneous with most models displaying some miscalibration. Some subgroups displayed considerable differences in performance: discriminative performance (AUROC) declined with increasing age and number of comorbidities, whereas the precision and recall improved with increasing age and number of comorbidities. We observed no difference in performance according to sex/gender or deprivation quintile.
Conclusions
Three models displayed moderate to strong performance predicting CKD among CPCSSN patients. Next, these models should be evaluated for their impact on practitioner and patient outcomes when implemented in clinical practice. If successful, these models hold promise in achieving widespread adoption to help identify those at highest risk of CKD and guide therapies that may prevent or delay CKD and related sequelae (e.g., end-stage renal disease) among people with diabetes.
Exploiting shared omics architecture and causal association between complex traits and COVID-19
Authors: Eshetie Setegn , Stacey David , Benyamin Beben , Lee S. Hong
Published: February 2025

Background
Understanding the shared biological and environmental correlations between COVID-19 and relevant complex traits may provide insights to mechanistic pathways and shared markers.
Methods
In this study, we employed bivariate Genomic-based Restricted Maximum Likelihood (GREML) to assess correlations between COVID-19 and 35 relevant complex traits, followed by Mendelian randomization (MR) to investigate potential causal links. To do that, we used phenotypic and omics data (genomic, transcriptomic, proteomic, metabolomic, and exposomic) from up to 107,857 participants from the UK Biobank.
Results
No genetic or transcriptomic correlations were found between COVID-19 and the traits. However, proteomic analysis revealed significant positive correlations with cardiometabolic traits (e.g., from r = 0.28 for chronic renal failure to r = 0.43 for heart disease) and pneumonia (r = 0.22). It also showed negative correlation with peptic ulcer (r = -0.26) and biomarkers (cystatinc-c: r = -0.19 and urea: r = -0.23). Metabolomic correlations identified strong associations with hormone-sensitive cancer (r = 0.72) and obesity-related cancer (r = 0.60), while negative correlations were observed for HDL cholesterol ( r= -0.34) and vitamin D (r = -0.32). Exposomic correlations mirrored proteomic findings with significant links with cardiometabolic traits such as heart diseases (r = 0.52) and stroke (r = 0.56). MR analysis indicated that none of the examined traits exhibited causal effects on COVID-19, suggesting that the observed omics correlations resulted from horizontal pleotropy, where omics factors independently influence both COVID-19 and complex traits.
Conclusions
Our study has demonstrated a shared omics architecture at proximal layers between COVID-19 and relevant traits. However, MR analysis showed no causal effects of these traits on COVID-19, suggesting distinct causal mechanisms from the omics layers.
Restoring Vision in SLE: Successful Management of Lupus Retinopathy – A Case Report
Authors: Hasan Md Mehedi , Proma Sanghita Banik , Imran Sakan Binte , Hossain Tanjila , . Amiruzzaman
Published: February 2025

Background
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which significantly affects multiple organs, including the ocular structures. Lupus retinopathy is one of those ocular manifestations, characterized by retinal ischemia and microvascular damage.
Case Summary
During a study on retinal changes of Systemic Lupus Erythematosus (SLE) patients, we coincidently noticed some cases with lupus retinopathy, whose retinal changes were reversible after getting treatment for Systemic Lupus Erythematosus (SLE). This case report belongs to those cases. This case report presents a 45-year-old female who had initial complaints of blurred vision in right of eye. The patient was concurrently diagnosed as Systemic lupus erythematosus (SLE), evidenced by polyarticular pain, fever and positive immunological and serological markers. The patient's visual symptoms significantly improved after receiving high dose glucocorticoids and immunosuppressive medications targeted towards her systemic symptoms of SLE. The follow-up exam showed that her vision had fully recovered and that his retinal lesions had resolved.
Conclusion
This case highlights the significance of lupus retinopathy as a potential early ocular manifestation of Systemic Lupus Erythematosus (SLE). Recognizing lupus retinopathy in its initial stages can not only prevent severe visual impairment but also facilitate the early diagnosis of SLE. Regular ophthalmologic screening is therefore essential in patients at risk, as it can play a pivotal role in the timely diagnosis and management of SLE.
Improving the effects of industrial robot adoption on employment, total factor productivity, and real wages in 52 world economies and OECD members
Authors: Matsuki Takashi
Published: February 2025

This study investigates the effects of industrial robot adoption in production process on unemployment rate, employment ratio in manufacturing, and total factor productivity (TFP) growth in 52 countries, and real wage growth in 31/20 OECD member countries for 2007–2019. The operating stock of robots per employee significantly impacts these variables; robot adoption lowers the unemployment rate and raises TFP and real wage growth. However, it reduces the employment ratio in manufacturing. In addition, the slight but significant positive contribution of robot adoption is observed only in the 90-percentile (top 10-percentile) of the real wage distribution. Interestingly, workers in the bottom and top tails (10- and 90-percentiles) of the wage distribution asymmetrically benefit from robotization. The industry ratio of value-added or information and communication technology (ICT) development improves the labor market by reducing the unemployment rate and raising the employment ratio in Asia’s manufacturing, TFP growth, and real wage growth.
JEL classification: C12; C32; C33
A new protection scheme of intersystem fault for AC/DC hybrid overhead lines
Authors: Yan Tao , Xiangping Kong , Chenqing Wang , Junchao Zheng , Zijun Bin , Jinjiao Lin , Sudi Xu
Published: February 2025

Transforming the existing key HVAC transmission lines into High Voltage Direct Current (HVDC) transmission systems is a new type of transmission capacity expansion scheme, which has been applied in power systems in Germany, the United Kingdom and other regions. After the occurrence of AC-DC intersystem faults, the fault characteristics are complex, and the protection adaptability will be affected. At present, there is no specific protection scheme for AC-DC intersystem faults. In this paper, a protection scheme based on the same side current similarity characteristics of AC and DC transmission lines is proposed, and the effective value of the scheme is verified on the simulation platform.
Exploring fertility practices in Mattrouh Governorate in Egypt
Authors: Oraby Doaa , Amin Tarek Tawfik
Published: February 2025

Background: Egypt’s National Population Council (NPC) is the body responsible for shaping the population policies in the country through research endeavors and proposing strategic directions. To support its’ mission, NPC conducts studies on alarming indicators emerging from 2021 Egypt’s Family Health Survey in selected governorates. The current study focuses on Mattrouh, a frontier governorate with high fertility rates, low contraceptive prevalence, wide spreading childhood marriage, and with large family size. The study aims to understand barriers and opportunities related to relevant fertility practices.
Methods: The research adopted qualitative methodology using focus group discussions (FGDs) in addition to desk review. Nine FGDs were conducted with married women, married men, mothers–in-law and community leaders from different regions within Matrouh governorate. The participants were recruited by the NPC branch in Mattrouh.
Results: Misconceptions about the safety of modern FP methods are dominated among users, inadequate acknowledgement of maternal and neonatal health risks of teenage pregnancies coupled with closely spaced births and limited knowledge about prerequisites for using traditional lactational amenorrhea as a family planning method were among the norms in this community and endorsed by the cultural values and motives.
Conclusion: Fertility practices are linked to deeply rooted beliefs embedded in the social fabric of this Bedwin and remote community. Sustained behavior change interventions including mass media programming and interpersonal communications addressing the prevalent FP related misconceptions and myths, combating childhood marriage, are increasingly important to improve the fertility practices and build demand for and continued use of FP services.
Effects of the diet of the mosquito Anopheles gambiae s.l. on its resistance to an insecticide
Authors: K.N. Cissé , J.C. Koella , B. Koudou G.
Published: February 2025

Although genes responsible for resistance of mosquitoes against insecticides are common throughout malarious areas, it is not clear how much they affect the epidemiology of malaria, for resistance can be strongly affected by the environment. We therefore focused on the diet of Anopheles gambiae, an important aspect of their environment, with two experiments investigating how sugar and blood meals affect their resistance to deltamethrin. The first focused on sugar meals taken from different plants and on the time between the blood meal and the exposure to the insecticide. Mosquitoes had continuous access to Tevethia nerifolia, Ixora coccinea or Mandalium coromandelianum as sugar meals, and half of the mosquitoes received a blood meal. After 15–18 hours (i.e., at a time when digestive genes are upregulated) or 60–63 hours (i.e., after digestion) we exposed them to 0.5% deltamethrin for one hour and measured the proportion of mosquitoes that were knocked down during the exposure and that died within the next 24 hours. The plant had no effect on the rates of mortality or knock-down. If the mosquitoes were exposed earlier, blood-feds were 22.7% less likely to die and 10.0% less likely to be knocked down than unfeds,, but if they were exposed later, blood-feeding increased mortality by 8.7% and knock-down by 14.0%. In the second experiment, we explored how the sugar-meal (consisting of the same three plants) interacted with the age at blood feeding. The mosquitoes were blood-fed or left unfed four or 11 days after emergence and exposed to the insecticide one day later. Neither the plant nor its interactions with blood meal or age affected mortality, but younger mosquitoes had lower mortality (60.7%) than older ones (66.4%), independently of their blood-meal. Similarly, the plant had no effect on knock-down rate, but the blood meal increased it by 14.5% in young mosquitoes and reduced it by 21.5% in old ones. These results underline the complex role of the mosquitoes’ diet on their response to insecticides.
Perception and Visibility of the State: The Ramayan of the Maranao: Rethinking Aquapelagos in the Philippines’ Sulu Sea
Authors: Magan Rhodora
Published: February 2025

This study contends that the Maranao people’s induction into the Tausug community of the Sulu aquapelago in the Philippines – an induction supervised by the colonial state – exemplifies a case of dialectical insularity or aquapelagicity in the production of a unique islandic identity that evolves through the deconstruction of Ramayan legends within templates of Darangen mythology. While numerous studies explore the role of myths and cultural narratives in reshaping and reinterpreting the identities of Muslim Filipinos, there is a notable scarcity of research specifically addressing how the Maranao community articulates its desired aquapelagic identity, particularly in the context of the ‘piratical’ movements and global commerce from the 16th to 18th centuries. Employing an interdisciplinary critical methodology, the study investigates how these reimagined myths provide affective sustenance for the Maranao’s imagined community, despite their, arguably, limited awareness of the Ramayan’s Indic, Hindu, and Puranic origins. The Maranao’s distinctive focus on Ravan (who is otherwise typically viewed as the Ramayan’s anti-hero in mainstream Indian interpretations) serves as a prominent index of their political praxis characterised by a unique affective dimension in their identity within Filipino cultures, the Malay Archipelago, and the larger Southeast Asian legacy of the Ramayan. This affective – or what I view as an aquapelagic – reinterpretation of the Ramayan within Maranao culture parallels the Tausug’s self-representation, characterised by ‘piratical’ assertions of their ‘Muslimness’ and their political stance on the Sabah dispute. This occurs within a decolonial framework that unveils the identity of the archipelago as an aquapelago, encompassing the marginal voices that shape its emancipatory future. Eventually, this constitutes a resistance to cultural and psychological erasure by colonial legacies – a resistance that influences the ongoing discourse of preserving unique political identities in the Malay archipelago and the wider Southeast Asian region.
PITUITARY COMA REVEALING SHEEHANS SYNDROME: A CASE REPORT
Authors:   Endocrinology, Diabetology, Metabolic Diseases and Nutrition Department, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Rania Dassoufi , Aden Neima Hassan ,   Endocrinology, Diabetology, Metabolic Diseases and Nutrition Department, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Sara Ijdda ,   Endocrinology, Diabetology, Metabolic Diseases and Nutrition Department, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Mghari. Ghizlane EL ,   Endocrinology, Diabetology, Metabolic Diseases and Nutrition Department, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Ansari Nawal EL ,   Endocrinology, Diabetology, Metabolic Diseases and Nutrition Department, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech.
Published: February 2025

Introduction:Postpartum hypopituitarism has been known as Sheehan syndrome since 1937. It is often an insidious revelation but can also be an acute one with coma and collapse, which was the case of our patient reported below.

Clinical case: Patient aged 37, admitted to the intensive care unit in a state of anasarca and coma. In view of her clinical features associated with hyponatremia, acute adrenal insufficiency was suspected. requiring degressive boluses of hydrocortisone hemisuccinate. The diagnosis was supported by biological evidence. Subsequent medical records revealed a haemorrhagic haemorrhagic childbirth dating back 6 years with absence of lactation and progressively incapacitating physical and psychological asthenia. Sheehans syndrome was suspected in this clinical situation and confirmed on MRI. The patient was put on daily oral replacement of the deficient axes.

Discussion: Myxedema coma is exceptional in Sheehans syndrome. Severe forms require an initial stay in intensive care, followed by multidisciplinary consultation in order to manage the multiple complications and to introduce hormone replacement therapy.
Deep Reinforcement Learning and Structure-Based Approaches in the de novo Design of a New Potential Inhibitor of F13 Protein from Monkeypox Virus
Authors: B. Alencar Filho Edilson , F. Oliveira Neto Rosalvo , C. Santos Vanessa , L. S. Ferreira Allysson
Published: February 2025

Monkeypox (MPOX) is a zoonotic infectious disease caused by the monkeypox virus (MPXV)
and has recently emerged as a significant concern for public health organizations globally. In
2022, the World Health Organization (WHO) reported thousands of laboratory confirmed cases,
mobilizing the scientific community to control this phenomenon due to its emergency nature.
Tecovirimat (TPOXX), a drug primarily recognized for the treatment of smallpox, has also
been recommended for managing MPOX. It works by inhibiting the viral F13 protein (VP37), a
critical component in the replication cycle of the virus. Some issues related to the possibility of
drug resistance by the virus, the intrinsic chemical complexity of this molecule and the limited
availability of therapeutic alternatives highlight the urgent need to explore and identify new effective
compounds. In this paper, we propose the combination of modern machine learning techniques
(deep reinforcement learning) with structure-based drug design (SBDD) approaches (molecular
docking and dynamics) in the de novo design of molecular scaffolds with affinity for the F13
protein, lower structural complexity than TPOXX and easy synthetic accessibility, contributing
to efforts in the search for therapeutic alternatives for MPOX.
PRAWNE ASPEKTY POLITYKI INTEGRACYJNEJ CUDZOZIEMCÓW NA PRZYKŁADZIE INDYWIDUALNEGO PROGRAMU INTEGRACJI
Authors: Cendrowicz Dominika
Published: February 2025

Integracja i polityka integracji cudzoziemców są od wielu lat przedmiotem dyskusji w krajach europejskich, w tym na poziomie całej Unii Europejskiej. Można powiedzieć, że kwestia integracji cudzoziemców ze społeczeństwem kraju przyjmującego jest wieloaspektowa i złożona. Na przestrzeni ostatnich kilkunastu lat Polska stała się jednym z krajów unijnych, do których licznie napływają cudzoziemcy spoza Unii Europejskiej, a w związku z wybuchem wojny na Ukrainie – obywatele tego państwa, którzy zostali zmuszeni do opuszczenia swojego kraju w poszukiwaniu schronienia. Zgodnie z podstawową tezą niniejszego artykułu pomoc społeczna zajmuje ważne miejsce w systemie polityki integracyjnej cudzoziemców, przy czym konieczny jest dalszy rozwój jej instrumentów prawnych na rzecz integracji cudzoziemców, a w dalszej perspektywie niezbędne jest opracowanie założeń kompleksowej polityki publicznej podejmującej kwestię integracji cudzoziemców. Celem artykułu jest analiza formy pomocy społecznej o charakterze integracyjnym realizowanej w ramach indywidualnego programu integracji skierowanego do uchodźców i cudzoziemców korzystających w Rzeczypospolitej Polskiej z ochrony uzupełniającej oraz próba oceny jej regulacji prawnej. W publikacji wykorzystano metodę dogmatyczno-prawną.
„WARSZTATY NAUKOWE INDEX 2.0”, ŁóDŹ 19 WRZEŚNIA 2023 ROKU
Authors: Pokrywka Szymon
Published: February 2025

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NAKAZ OPRÓŻNIENIA BUDYNKU GROŻĄCEGO ZAWALENIEM W ORZECZNICTWIE SĄDÓW ADMINISTRACYJNYCH
Authors: Maziarz Aleksander
Published: February 2025

Celem opracowania jest analiza i ocena art. 68 prawa budowlanego, który umożliwia nakazanie opróżnienia bądź wyłączenia budynku z użytkowania z uwagi na bezpośrednie zagrożenie zawaleniem. W szczególności przeanalizowane zostały przesłanki stosowania tego przepisu w kontekście jednego z zasadniczych celów prawa budowlanego, jakim jest zapewnienie bezpieczeństwa obiektów budowlanych. Rozważania przeprowadzono przy użyciu metody formalno-dogmatycznej na tle orzecznictwa sądów administracyjnych. Szczególną uwagę poświęcono ocenie zakresu zastosowania art. 68 prawa budowlanego, zbadano zakres podmiotowy tego przepisu i dokonano oceny wykonalności nakładanych w trybie tego przepisu obowiązków w praktyce. Ustalenia te posłużyły do sformułowania postulatów de lege ferenda.
EUROPEAN CROSS-BORDER ASSOCIATIONS: ON THE SOCIAL FUNCTION OF LAW
Authors: Dąbrowska Justyna
Published: February 2025

The aim of this article is to answer the question of the potential eﬀectiveness of introducing the regulation on European cross-border associations (ECBAs) into the national legal systems of EU Member States. The goal of this initiative is to facilitate the cross-border activities of non-profit associations in the European Union, with the aim of improving the operation of the internal market by removing legal and administrative barriers and levelling the playing field for non-profit associations which operate or wish to operate in more than one Member State, thereby promoting the role that non-profit associations play in generating economic and social value in the EU. In its first part, the article discusses the origins of the European Commission’s proposal and presents the proposed structure and principles of operation of the ECB. In the second part, the article contains conclusions and doubts concerning the Commission’s proposal, also referring to the Polish legal regulations relating to associations and legal solutions operating in other EU countries. Rather than systematically or thoroughly discussing association law in the EU, the article intends to address certain elements of the proposed Directive, but above all to contribute to a doctrinal discussion on this subject, including how research on European cross-border associations should be conducted. I use the example of the planned regulation to illustrate the question of the impact of the law as a carrier of value in bringing about the expected social changes. I focus my considerations on the concept of the law’s social function to ensure legal eﬀectiveness. However, eﬀectiveness should not be understood as compliance of the social results of a set of legal norms with the legislator’s intentions, but instead as the situation when the law is well embedded institutionally and leads to an increase in social and individual utility.
PRZESŁANKI ZASTOSOWANIA ULGI Z TYTUŁU DAROWIZNY NA CELE KULTU RELIGIJNEGO. GLOSA KRYTYCZNA DO WYROKU NACZELNEGO SĄDU ADMINISTRACYJNEGO Z 20 KWIETNIA 2022 R., II FSK 709/20
Authors: Namieciński Bartosz
Published: February 2025

Niniejsza glosa odnosi się do problematyki przesłanek koniecznych do zastosowania ulgi z tytułu darowizny na cele kultu religijnego w podatku dochodowym od osób fizycznych. W treści przedstawionej glosy wskazano, że problematyka ta stanowi nie tylko ważną, ale i sporną konstrukcję prawną. Głównym celem badawczym opracowania jest weryfikacja i ocena obecnie obowiązujących regulacji prawnych związanych z zastosowaniem tej ulgi. W artykule krytyce poddano rozważania Naczelnego Sądu Administracyjnego. Stanowisko sądu nie zasługuje na aprobatę, wymaga bowiem od podatnika do zastosowania ulgi, spełnienia dodatkowej przesłanki niewymienionej wprost w przepisach ustawy podatkowej. Potwierdza to nie tylko wykładnia wskazanych przepisów, lecz także przedstawione stanowiska doktryny i judykatury, z którymi glosowane orzeczenie jest niezgodne. W konsekwencji wyrok ten zakłada błędną, rozszerzającą wykładnię przepisów ustawy o podatku dochodowym od osób fizycznych. W opracowaniu zastosowano przede wszystkim metodę case study, uzupełnioną o metodę dogmatyczną. Analizie poddano obecnie obowiązujące ustawodawstwo polskie w dziedzinie prawnopodatkowej dotyczącej zastosowania ulgi z tytułu darowizny na cele kultu religijnego. Ponadto analizą objęto orzecznictwo sądów polskich oraz poglądy doktryny przedmiotu.
Morfologia da língua do peixe-boi-marinho Trichechus manatus manatus, Linnaeus, 1758 e suas implicações adaptativas na dieta herbívora
Authors:   , Melo Lucas Inácio dos Santos
Published: February 2025

O estudo morfológico da língua é uma ferramenta interessante na compreensão dos processos
evolutivos associados aos hábitos alimentares. Há escassez de informações morfológicas
sobre a língua do peixe-boi-marinho das Antilhas (Trichechus manatus manatus). Assim, o
objetivo deste estudo foi descrever a morfologia da língua de T. m. manatus para estabelecer
um modelo padrão para a espécie, e entender a relação morfológica com a dieta herbívora.
Foram realizadas análises de dissecação macroscópica, microscopia de luz e microscopia
eletrônica de varredura de sete línguas. A língua apresentou-se como um órgão musculoso e
robusto, dividido em ápice, corpo e raiz. Firmemente aderia ao assoalho da cavidade oral. As
papilas linguais estavam distribuídas sobre toda a superfície do órgão, identificadas como
papilas filiformes, concentradas na região do ápice, papilas fungiformes encontradas nas
regiões do ápice e lateral da língua, papilas foliáceas localizadas na porção dorsolateral da raiz
da língua. A mucosa revestida por epitélio escamoso estratificado queratinizado, presença de
glândulas do tipo tubuloacinares compostas, além de botões gustativas nas papilas foliáceas.
Esta disposição das papilas gustativas está intimamente relacionada a adaptações para a dieta
herbívora, pois irão apresentar as papilas mecânicas no ápice e papilas com percepção
química pelos botões gustativos na porção de raiz, com presença de glândulas por toda a
língua, possuindo pouca ou quase nenhuma percepção química. Em conclusão, a língua do
peixe-boi-marinho das Antilhas foi semelhante às outras espécies da ordem Sirenia, os quais
compartilham de uma dieta principalmente herbívora.
Efeito da ingestão de extrato etanólico de própolis sobre a produção, parâmetros fisiológicos e bem-estar de vacas leiteiras
Authors:   , Varela Ana Michell García
Published: February 2025

Foram utilizadas 3 vacas primíparas da raça Holandês, com uma média de 90 dias do
período de lactação, com a mesma ordem de parto, a mesma idade e uma média de peso corporal
de 485   kg. Objetivou-se avaliar o consumo das vacas, o desempenho na produção de leite
e parâmetros ficológicos. As vacas foram distribuídas aleatoriamente em quadrado latino 3 x 3
repetidos duas vezes no tempo, com três períodos e três tratamentos. Os tratamentos foram
divididos em: tratamento controle 1 (0 ml de extrato etanólico de própolis), tratamento 2 (32
ml/dia de extrato etanólico de própolis), tratamento 3 (64 ml/dia de extrato etanólico de
própolis). As vacas foram alojadas em baias individuais semifechadas com ventilação livre
durante todo o período experimental e submetidas a duas ordenhas diárias (07:00 h e 13:30 h)
realizadas manualmente por um ordenhador experimentado. Cada período teve duração de 17
dias, divididos em 12 dias para adaptação e 5 dias de coleta de dados. Cada quadrado latino
teve duração de 51 dias repetidos no tempo, totalizando 102 dias do período experimental. A
dieta fornecida para os animais em experimentação consistiu em ração concentrada e silagem
de milho, com relação volumoso:concentrado de 50:50. O extrato etanólico de própolis (EEP)
testado nas vacas tinha uma concentração de 4,04% de compostos fenólicos totais. A adição de
extrato etanólico da própolis na dieta de vacas leiteiras não afetou (P > 0,05) consumo dos
nutrientes, composição do leite nem os parâmetros sanguíneos. No entanto, houve uma
tendência a diferencia na produção de leite, as vacas suplementadas com o maior nível de
extrato etanólico da própolis (64 ml/d) produziram mais leite em relação aos demais
tratamentos. Entretanto, houve um consumo de matéria seca de 18,96 kg/d e não foi
influenciado por a ingesta do estrato da própolis, o consumo de proteína bruta e carboidratos
não fibrosos também não foram afetados mantendo uma média de 2,83 kg/d, 6,62 kg/d.
Recomendasse a oferta de 64 ml de extrato de própolis por aumentar a produção de leite,
melhorar a eficiência alimentar e não influenciar negativamente sobre a qualidade do leite.
Morfologia testicular de juvenis de Oscar Astronotus Ocellatus AGASSIZ, 1831 (PIRCES: Perciformes, Cichlidade)
Authors:   , Albuquerque Danilo Lourenço de
Published: February 2025

Dentre os teleósteos, o Astronotus ocellatus (Oscar) se destaca pela sua beleza e
docilidade despertando grande interesse dos aquariofilistas, necessitando de maior
compreensão dos elementos que compõe sua reprodução. Com isso, objetivou-se
caracterizar as gônadas de machos de Astronotus ocellatus (Oscar) juvenis, através de
avaliações morfológicas, morfométricas e estereológicas. Macroscopicamente os animais
tiveram seus dados biométricos coletados e suas gônadas avaliadas quanto localização e
morfologia. Microscopicamente as gônadas foram processadas através de histologia
padrão de luz e avaliadas quanto à sua morfologia, estereologia e morfometria. Através
do cálculo de diâmetro, os dados obtidos foram submetidos à estatística descritiva através
do DP (± desvio padrão), no qual foram determinados o diâmetro das espermatogônias
primárias e secundárias. Macroscopicamente as gônadas apresentaram estruturas lisas,
bilaterais, filiforme, alongadas, uniforme, de cor translúcida a esbranquiçada, aderidos
dorsalmente à cavidade celomática, cranialmente bifurcados e caudalmente se unem
originando o ducto espermático, que segue até a papila urogenital para que ocorra a
espermiação, apresentando IGS de 0,023. Microscopicamente foi observado a presença
da túnica albugínea revestindo o testículo na sua porção externa e internamente observouse a diferenciação das gônadas em região tubular e intertubular. Na região tubular foram
observados cistos de células grandes, com núcleo redondo a ovoide, basofílico, cromatina
condensada apresentando um ou dois nucléolos e citoplasma pouco evidente, que foram
identificadas como espermatogônias primárias e secundárias. As espermatogônias
primárias apresentaram maior tamanho entre as células da linhagem germinativa (9,85 ±
1,13 µm) e cromatina menos densa. Já as espermatogônias secundárias possuíam tamanho
menor (7,04 ± 0,78 µm), cromatina mais densa, com aglomerados redondos dispostos
sobre o envelope nuclear. Na região intertubular foram observados a presença de vasos
sanguíneos, tecido conjuntivo frouxo e células de Leydig. Na avaliação estereológica do
compartimento testicular, foi evidenciado maior predominância das estruturas que
compõem o compartimento tubular (88%), como espermatogônias primárias,
espermatogônias secundárias e células de Sertoli, e menor proporção de compartimento
intertubular (12%).