bluuebunny/crossref_metadata_2025 huggingface dataset:
Physico-Chemical and Phytochemical Characterization of Moroccan Wild Jujube “Zizyphus lotus (L.)” Fruit Crude Extract and Fractions
Authors: Cadi Hafssa El , Bouzidi Hajar EL , Selama Ginane , Cadi Asmae El , Ramdan Btissam , Oulad El Majdoub Yassine , Alibrando Filippo , Dugo Paola , Mondello Luigi , Fakih Lanjri Asmae , Brigui Jamal , Cacciola Francesco
Published: November 2020

Wild jujube “Ziziphus lotus (L.) Desf.” belongs to the Rhamnaceae family and is a traditionally herbaceous medicinal plant. It is very common in arid and semi-arid regions and is currently used for its antidiabetic, sedative, analgesic, anti-inflammatory and hypoglycemic activities. The aim of the present work was to characterize the physico-chemical properties and the phytochemical profile of wild jujube sample collected from the Guercif region, in order to determine the polyphenolic compounds and the antioxidant ability Analyses were carried out directly after the harvest for the determination of pH, refractive index, total soluble solid (°Brix), dry matter, sugar/acidity, total sugars, reducing sugars, as well as lipid and protein content. Results showed that the investigated fruit is acidic (pH 4.9 ± 0.23) and rich in sugars (80.2 g/100 g ± 3.81). The GC-MS analysis of the fruit revealed a number of volatile compounds, as many as 97, belonging to different chemical classes. The HPLC-DAD-ESI/MS analysis showed the presence of a total of 20 polyphenolic compounds in both EtOAc and MeOH-water extracts. Among them, p-Hydroxybenzoic acid was the most abundant in the EtOAc extract (185.68 µg/100 mg ± 0.5) whereas Quercetin 3-O-rhamnoside-7-O-glucoside was found in higher amounts in the MeOH-water extract (25.40 µg/100 mg ± 0.5). These components have medical interest, notably for human nutrition, as well as health benefits and therapeutic effects. Therefore, Moroccan jujube “Zizyphus lotus (L.)” fruit may have potential industrial applications for food formulations.
The Light Dependence of Mesophyll Conductance and Relative Limitations on Photosynthesis in Evergreen Sclerophyllous Rhododendron Species
Authors: Yang Ying-Jie , Hu Hong , Huang Wei
Published: November 2020

Mesophyll conductance (gm) limits CO2 diffusion from sub-stomatal internal cavities to the sites of RuBP carboxylation. However, the response of gm to light intensity remains controversial. Furthermore, little is known about the light response of relative mesophyll conductance limitation (lm) and its effect on photosynthesis. In this study, we measured chlorophyll fluorescence and gas exchange in nine evergreen sclerophyllous Rhododendron species. gm was maintained stable across light intensities from 300 to 1500 μmol photons m−2 s−1 in all these species, indicating that gm did not respond to the change in illumination in them. With an increase in light intensity, lm gradually increased, making gm the major limiting factor for area-based photosynthesis (AN) under saturating light. A strong negative relationship between lm and AN was found at 300 μmol photons m−2 s−1 but disappeared at 1500 μmol photons m−2 s−1, suggesting an important role for lm in determining AN at sub-saturating light. Furthermore, the light-dependent increase in lm led to a decrease in chloroplast CO2 concentration (Cc), inducing the gradual increase of photorespiration. A higher lm under saturating light made AN more limited by RuBP carboxylation. These results indicate that the light response of lm plays significant roles in determining Cc, photorespiration, and the rate-limiting step of AN.
A New Control Performance Evaluation Based on LQG Benchmark for the Heating Furnace Temperature Control System
Authors: Li Haisheng , Li Rongxuan , Wu Feng
Published: November 2020

Temperature control systems are a series of processes with large time-delay and non-linear characteristics. Research shows that using fractional-order modeling and corresponding control strategies can better control these processes. At the same time, the existing studies for control performance assessment are almost committed to the integer order control systems, and the methods used in few literatures on performance assessment of fractional order systems are also one-sided. This paper applies the linear quadratic Gaussian (LQG) evaluation benchmark to the performance evaluation of fractional-order control systems for the first time, starting with the LQG evaluation benchmark considering the input and output performance. The LQG benchmark can be obtained by the analytical algorithm, which simplifies the complexity of LQG solution. Finally, taking the application of the fractional predictive function control (FO-PFC) controller in the experiment of industrial heating furnace temperature control as an example, the effectiveness of the LQG benchmark is verified.
Microwave-Assisted Pyrolysis of Pine Wood Sawdust Mixed with Activated Carbon for Bio-Oil and Bio-Char Production
Authors: Khelfa Anissa , Rodrigues Filipe Augusto , Koubaa Mohamed , Vorobiev Eugène
Published: November 2020

Pyrolysis of pine wood sawdust was carried out using microwave-heating technology in the presence of activated carbon (AC). Experimental conditions were of 20 min processing time, 10 wt.% of AC, and a microwave power varying from 100 to 800 W. The results obtained showed that the microwave absorber allowed increasing the bio-oil yield up to 2 folds by reducing the charcoal fraction. The maximum temperature reached was 505 °C at 800 W. The higher heating values (HHV) of the solid residues ranged from 17.6 to 30.3 MJ/kg. The highest HHV was obtained for the sample heated at 800 W with 10 wt.% of AC, which was 33% higher than the non-charged sample heated at the same power. Furthermore, the addition of AC allowed showing the probable catalytic effect of the AC in the charged sample pyrolysis bio-oils.
HISTÓRIAS DE TRANSFORMAÇÃO NAS VIDAS DOS USUÁRIOS DO PROGRAMA SEGUNDO TEMPO (PST) DE JABOATÃO DOS GUARARAPES
Authors: Lima Marcus Vinicius Sanchez , Modenesi Thiago Vasconcellos
Published: November 2020

A presente pesquisa que se insere nos estudos de abordagem qualitativa na área da Educação Física toma como foco central as questões relacionadas ao Programa Segundo Tempo desenvolvido no município de Jaboatão dos Guararapes. Visamos aqui responder ao problema de pesquisa em que discutimos como as vivências em programas sociais se caracterizam nas contribuições que possam ter um cunho transformador, isso feito a partir da literatura e das entrevistas realizadas, onde estas possam evidenciar este caráter mudancista. O debate pretende contribuir com uma leitura mais refinada das políticas públicas de esporte e lazer construídas a partir da eleição do presidente Luís Ignácio Lula da Silva, através de algumas reflexões, conceitos e procedimentos metodológicos, que constituem parte fundamental das ferramentas de pesquisa do pesquisador social, particularmente aqueles que buscam uma leitura sociocultural do esporte, do lazer e das temáticas correlatas. Para tanto utilizamos alguns autores do campo científico/acadêmico da Educação Física, bem como recorremos a alguns agentes de outras áreas do conhecimento, que com suas contribuições fundamentam o universo pesquisado.
IMPLICACIONES DEL DIÁLOGO EN LA ENSEÑANZA: DE LA NEGOCIACIÓN A LA CREACIÓN DE CULTURA
Authors: Lima Rafael Correia
Published: November 2020

La investigación es un recorte de la tesis doctoral, análisis de los diálogos como práctica pedagógica en la enseñanza: la relación desarrollada por los docentes y estudiantes, aprobada en la Universidad Nacional de Rosario, que hace discusiones del capítulo, el lenguaje en la educación, desarrollado por Jerome Bruner (1985), en su planteo trató de las implicaciones de negociación del lenguaje. El objetivo de la investigación es analizar el alcance de los conceptos del autor, complementándolos y poniendo a prueba para enfatizar soluciones prácticas de negociación que no contempla en su teoría. El referencial teórico charla con el autor Burbules (1999), Habermas (1976), Searle (1962) y Grice (1989). Es un estudio teórico que presenta una síntesis del diálogo en la enseñanza, las principales implicaciones del lenguaje de la educación, la negociación y las reglas del juego en el lenguaje que abarcan los hallazgos de la práctica escolar, desde la negociación a la creación de cultura planteada por el autor.
Hand hygiene implementation: an easy step to improve public health
Authors: Fankhauser-Rodriguez Carolina , Guitart Chloé , Pittet Didier
Published: November 2020

The World Health Organization has declared 2020 the “Year of the Nurse and Midwife”. On May 5th of this year, for the annual celebration of the SAVE LIVES: Clean Your Hands campaign, the WHO highlighted the critical role of nurses and midwives in promoting public health. Increasing well-trained nurse staffing will enable nurses and midwives to improve quality of care and prevent infections. The implications for improved nursing and health policy are many. Investing in nurses ensures better care for patients, reduces infections and the economic burden of healthcare-associated infections on countries' economies.
Adherence with the WHO's hand hygiene recommendations in an Algerian university hospital
Authors: Chelghoum Mustapha , Lariche Nadjet , Belbah Ismahene
Published: November 2020

Adherence to hand hygiene recommendations by health care workers (HCWs) participate to minimize healthcare-associated infections. There are few studies, to our present state of knowledge, which interested in the rate of adherence in Algerian hospitals and no one on the associated factors with the non-adherence by HCWs. The objective was to determine the rate of adherence with WHO's hand hygiene recommendations and to identify factors associated with non-adherence, in a regional university hospital. The method used was the direct observation, based on the recording of hygienic actions in opportunities for HCWs in front of the WHO's five indications. To determine the factors associated with non-adherence, a questionnaire was administrated to HCWs. The relationship between the different factors and the achievement of a hygiene action was evaluated by Pearson's Chi-square test. 503 opportunities for hand hygiene were observed among 206 HCWs, during 19 observation sessions. Simple handwashing was noted in 19% of hand hygiene actions. The overall adherence was 21 %. There was a wide variation in the adherence rates between the different departments and the different types of HCWs. There was a statistically significant association (p
The assessment of knowledge, attitude and practice towards tuberculosis infection control among health professionals in Nekemte referral hospital, Nekemte, Oromia, West Ethiopia: cross sectional facility based study
Authors: Golja Eba Abdisa
Published: November 2020

Infection control remains a key challenge for Tuberculosis control program with an increased risk of Tuberculosis transmission among health care workers. Poor knowledge, poor practice and poor attitude among health care workers and inadequate infection control practices may lead to the increased risk of nosocomial Tuberculosis transmission. People living in the same household, or who otherwise are in frequent contact with an infected patient have the greatest risk of being exposed to the bacilli.

This study was aimed to assess knowledge, attitude and practice of health professionals towards tuberculosis infection control in Nekemte referral hospital, Nekemte, west Ethiopia, 2018.

Institutional based cross sectional study design was conducted from December 2017 to January 2018 among 223 health professionals in Nekemte referral hospital. Data was collected by using self-administered structured questionnaires which has subdivided components, and finally the analysis was done by double entry of SPSS version 21.

Two hundred study participants responded to our current study with response rate of 200(89.6%). In this study, majority of respondents, 54% were females and 55% of them are first degree holders. From 200 participants, 14 (7%) had poor knowledge. Majority, 157(78.5%) of health care workers, had positive attitudes towards Tuberculosis infection control. Sixty (30%) of participants had poor practice.

This study found that significantly high proportion of health workers had good knowledge and practice towards tuberculosis infection control. More than half of health workers wrongly believed that surgical mask can protect health workers from inhaling mycobacterium containing aerosols.
Impact of Mass Screening on the Number of Confirmed Cases, Recovered Cases, and Deaths Due to COVID-19 in Iran: An Interrupted Time Series Analysis
Authors: Taheri Soodejani Moslem , Tabatabaei Seyyed Mohammad , Dehghani Ali , McFarland Willi , Sharifi Hamid
Published: November 2020

Background: Mass screening for the coronavirus disease 2019 (COVID-19) began in Iran on March 23, 2020, with the purpose of improving early detection of patients for their own health and to prevent onward transmission to others. In this study, we evaluated the impact of the change towards mass screening on new cases reported, cases recovered, and deaths due to COVID-19. Methods: This study analyzed the daily reports on the number of new cases confirmed by polymerase chain reaction (PCR) testing, cases recovered, and deaths due to COVID-19 provided to the Ministry of Health and Medical Education of Iran. Changes in trends on these outcomes were evaluated using interrupted time series analysis. Results: From February 19 to May 6, 2020, a total of 519544 COVID-19 tests were done and 101650 diagnoses were made (case/ test ratio 19.6%). For the same period, 6418 deaths due to COVID-19 were reported (case fatality ratio 6.3%). The number of cases detected increased significantly over the period of scale-up of mass screening (P=0.003), as did the number of recovered cases (P=0.001). The number of deaths due to COVID-19 did not change before versus after mass screening. Conclusion: Following the scale-up of mass screening for COVID-19 in Iran, the rate of new cases detected and reported recovered accelerated significantly. Mass screening is likely to have detected many mild and asymptomatic cases that were infectious. Our data support the role that mass screening, coupled with isolation and contract tracing, can have in slowing the COVID-19 epidemic.
Predictors of Success Rate in Different Initial Respiratory Supports in Very Low Birthweight Infants with Respiratory Distress
Authors: Fallahi Minoo , Taslimi Taleghani Naeeme , Afje Seyyed Abolfazl , Shamshiri Ahmad Reza , Esmaili Fatemeh , Radfar Mitra , Jafari Majid
Published: November 2020

Background: Ideal respiratory support for very low birth weight infants (VLBW) can be selected based on demographic and clinical status at birth. Methods: In this prospective cohort study, we included 163 VLBW neonates treated with either invasive or non-invasive respiratory support in their first 72 hours of life in the neonatal intensive care unit of Mahdiyeh hospital, Tehran, Iran. We used descriptive statistics to describe the data, and multiple logistic regression to determine the factors associated with the success rate of different strategies and the choice of strategy for primary respiratory support. All analyses were done using SPSS version 20 and STATA version 12 at a significance level of 0.05. Results: The success rates of initial respiratory supports with nasal continuous positive airway pressure (NCPAP), noninvasive positive pressure ventilation (NIPPV), and INSURE (intubation surfactant extubation) were 63.20%, 42.10% and 61.90%, respectively. The results of multiple logistic regression analysis showed patent arterial duct (PDA) (yes vs. no: OR = 0.42) had a significant effect on initial respiratory support success (P<0.05). Also, gestational age (>28 vs. ≤28 weeks: OR = 0.26) and 5-min APGAR (≤6 vs. >6: OR = 9.69) had a significant effect on the choice of initial respiratory support in VLBW infants (P<0.05). Conclusion: The neonatal clinical condition may be a predictor of success for initial respiratory support at birth. Since the arterial duct may be open during the first hours of life, more study is needed to verify if early closure of the arterial duct may help increase the success rate of non-invasive respiratory support.
Should different countries participating in PISA interpret socioeconomic background in the same way? A measurement invariance approach
Authors: Erylmaz Nurullah , Rivera-Gutiérrez Mauricio , Sandoval-Hernández Andrés
Published: November 2020

It has been claimed that there is a lack of theory-driven constructs and a lack of cross-country comparability in International Large-Scale Assessment (ILSA)’s socio-economic background scales. To address these issues, a new socio-economic background scale was created based on Pierre Bourdieu’s cultural reproduction theory, which distinguishes economic, cultural and social capital. Secondly, measurement invariance of this construct was tested across countries participating in the Programme for International Student Assessment (PISA). After dividing the countries which participated in PISA 2015 into three groups, i.e., Latin American, European, and Asian, a Multi-Group Confirmatory Factor Analysis was carried out in order to examine the measurement invariance of this new socio-economic scale.
The results of this study revealed that this questionnaire, which measures the socio-economic background, was not found to be utterly invariant in the analysis involving all countries. However, when analysing more homogenous groups, measurement invariance was verified at the metric level, except for the group of Latin American countries. Further, implications for policymakers and recommendations for future studies are discussed.
ELITISME ALGORITMA GENETIKA PADA FUNGSI NONLINEAR DUA PEUBAH
Authors: Fanggidae Adriana
Published: November 2020

Operator evolusi dalam algoritma genetika (AG) tidak menjamin kualitas individu dari generasi ke generasi selalu baik. Elitisme menjaga pelestarian sifat-sifat individu terbaik dari generasi ke generasi dengan cara menggandakan sekumpulan individu terbaik. Pada tulisan ini ditentukan banyaknya penggandaan yang perlu dilakukan terhadap individu terbaik. Pengujian dilakukan terhadap lima fungsi nonlinear dua peubah dan dihasilkan satu penggandaan individu terbaik mampu memberikan solusi terbaik.
PENGARUH ANIMISME: HILANGNYA KAHARINGAN DALAM PILIHAN AGAMA DI INDONESIA
Authors: Rosyadi Muhammad Sandy
Published: November 2020

Dalam tulisan ini, saya akan menjelaskan tentang salah satu agama lokal di Indonesia yaitu Dayak Kaharingan yang tidak dianggap sebagai agama oleh pemerintah Indonesia. Hal tersebut tidak terlepas dari peran pemikiran E B. Taylor tentang animisme yang merupakan sesuatu dari agama modern yang menganut tauhid. Akibatnya banyak agama atau kepercayaan yang masih menganut animisme seperti Dayak Kaharingan, akan dianggap sebagai kepercayaan yang bukan bagian dari agama tersebut. Jadi saya berpendapat ada kesalahan teori Taylor tentang animisme yang diterapkan pada agama-agama lokal saat ini.
Vigilancia Tecnológica: ¿Un proceso estratégico permanente o un plan situacional para las micro y pequeñas empresas en Colombia?
Authors: Vanegas Florez Oswaldo , MANJARRES ZARATE BENJAMÍN ANDRÉS
Published: November 2020

El presente artículo es una reflexión crítica acerca de la importancia que tiene la Vigilancia Tecnológica, como herramienta estratégica para garantizar el logro de los objetivos corporativos de las organizaciones, teniendo presente que en Colombia cerca del 95 % del censo empresarial corresponde a las micro y pequeñas empresas. De esta forma, se encuentran aspectos tales como la función de Vigilancia Tecnológica (VT) en la gestión de la información y el conocimiento, el panorama de la VT en Colombia (estudios realizados) y el ciclo de Vigilancia Tecnológica concebido no solo como un plan situacional o de contingencia en las organizaciones, sino como un proceso estratégico permanente que garantice la competitividad y productividad de las compañías; el objetivo general es describir el panorama de la Vigilancia Tecnológica en Colombia y reflexionar acerca del papel que desempeña dicho proceso como parte fundamental de la planeación, implementación y control de estrategias en la organización. De modo que a partir de la aplicación de un método de investigación documental, basado en el estado del arte y revisión de literatura, se puede deducir que el proceso de Vigilancia Tecnológica en Colombia aún se asume como una contingencia mas no como una práctica permanente y constante en las organizaciones, ya que el gerente de la micro y pequeña empresa desconoce los beneficios de este proceso, lo cual le permite fortalecer sus ventajas competitivas en el corto, mediano y largo plazos.Es así como se concluye que a pesar de la utilización creciente de herramientas tecnológicas enfocadas en la Vigilancia Tecnológica (VT) como proceso permanente, sobre todo en organizaciones pertenecientes a sectores estratégicos de la economía colombiana, es importante que el micro, pequeño y mediano empresario cambie sus paradigmas tradicionales en cuanto al diseño y aplicación de los procesos estratégicos en la organización, los cuales deben ser flexibles, sistémicos y complejos, anticipándose de manera oportuna y efectiva a las disrupciones y tendencias cambiantes del entorno global actual.
Diálogo: Educando nuestro ser, educando nuestra realidad
Authors: Soler Lemus David Leopoldo
Published: November 2020

Este artículo forma parte de una investigación sobre el diálogo socrático, rastrea pistas del desarrollo del pensamiento y conocimiento: la odisea de un niño que comienza cuando descubre que se halla extraviado de la vida. En sus incursiones, a través de escombros y peligros, busca diálogo, identificar vida humana, establecer relaciones con el mundo y consigo mismo. Sus experiencias lo hacen pensar que nació en un mundo que tiende a rechazarlo, dominarlo, someterlo. Sueña con la libertad, la creatividad. Al enterarse de que sus ancestros indígenas —dueños de sí mismos, de sus casas, señores en sus territorios, promotores de cultura en comunidad— fueron negados en su ser, despojados de sus tierras y vida comunitaria, sometidos al trabajo forzado o al exterminio, que similar ocurrió a sus ancestros afrodescendientes, comprende que el miedo, la pérdida de emprendimiento, moral y estilo de vida que se generó en ellos, en Colombia lo hemos heredado. En el método socrático, punto de partida de toda reflexión es la experiencia, vivida concretamente; aquí la odisea y la de nuestros ancestros. A la pregunta: ¿provoca el conocimiento crítico de las tradiciones, en quien las conoce, un impulso transformador? el diálogo socrático responde de forma afirmativa. El niño piensa críticamente la educación que recibe, entiende las razones de su soledad, imagina procesos educativos más propicios, para continuar aprendiendo y formándose. Conclusión: es indispensable reconstruir biografía y vida comunitaria. Las complejas tradiciones latinoamericanas enlazan valores e invalores de los cuales no hemos hablado suficientemente, para distinguirlos y dar contenido y sentido a las relaciones intergeneracionales.
Estudio prospectivo a 2023 para la institución educativa municipal Manuela Ayala de Gaitán de Facatativá
Authors: Narvaez Ferrín María Erika , Alonso Contreras Carlos Oswaldo
Published: November 2020

El objetivo de este artículo es diseñar un estudio prospectivo para la Institución Educativa Municipal Manuela Ayala de Gaitán, de Facatativá, al año 2023, enfocado en la gestión académica. Se realizó un diagnóstico a la organización mediante la herramienta PEST. Se definió un estudio de tipo mixto, no experimental de carácter descriptivo. Se diseñaron dos instrumentos, una encuesta de 47 preguntas distribuidas en 4 secciones tipo Likert con 5, 8, 5 y 4 ítems, respectivamente, dirigida a estudiantes. El segundo, un cuestionario para entrevista mediante la técnica Delphi con 14 preguntas para los expertos internos. La muestra está representada por 42 miembros de la comunidad educativa (estudiantes, docentes, directivos y personal administrativo). Se empleó el método Delphi, MICMAC, MACTOR y SMIC-PROB-EXPERT para definir los factores de cambio, las variables clave, el juego de actores y las estrategias, respectivamente. Para finalizar se obtiene un escenario de ruptura, cuatro tendenciales y uno apuesta, para el cual se formuló el plan de acción, y se concluye que con la implementación esta institución podrá mejorar el desempeño de los estudiantes, ser pionera en el uso de medios tecnológicos para dinamizar la actividad enseñanza–aprendizaje, y reducir la reprobación y deserción del sistema.
Integración de la educación digital y los aportes de las TIC, JCLIC a los procesos de enseñanza y aprendizaje en la escuela
Authors: Malpica Capacho Alonso
Published: November 2020

El propósito del artículo es hacer una reflexión desde la integración de     la educación digital y los aportes de las TIC, para identificar los aspectos relevantes de la contribución del software educativo JCLIC en los procesos de innovación escolar. En el texto se argumenta sobre la importancia que tienen los docentes para apropiarse e implementar a su práctica pedagógica habilidades, competencias digitales, etilos de aprendizaje y aplicaciones para entornos virtuales que ofrece la web; así mismo, se explica el papel del docente, en el uso de las herramientas tecnológicas, la interacción digital y los procesos de comunicación en la innovación a través del software JCLIC en el contexto escolar.
MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF TISSUE HOMEOSTASIS IN PATIENTS WITH ALOPECIA AREATA IN THE CHRONIC STAGE ASSOCIATED
WITH METABOLIC SYNDROME AND THE NON-BURDENED COURSE OF THE DISEASE
Authors: Vozianova Svitlana V. , Dyadyk Olena O. , Horda Inna I. , Radkevich Yaroslav S.
Published: November 2020

Introduction: Alopecia areata (AA) is a tissue-specific disease of the hair follicles, manifested by foci of baldness on the head and other areas of the skin.
The aim of the study was to identify the tissue homeostasis state on the basis of pathomorphological and immunohistochemical changes taking into account the
features of Ki67, bcl-2, caspase-3, and CD31 expression in patients with AA in the chronic stage associated with metabolic syndrome and the non-burdened course
of the disease.
Materials and methods: Pathomorphological and immunohistochemical studies of Ki67, bcl-2, caspase-3, and CD31 expression in biopsies specimens from skin
lesions in the chronic stage of the disease were performed in 11 patients with AA associated with metabolic syndrome and the non-burdened course of the disease.
Results: The results of complex morphological study showed that in skin biopsies of patients with AA with metabolic disorders pathomorphological changes were
more affected both in the epidermis and skin appendages – degenerative changes in the epithelium, in the dermis, manifestations of appendage atrophy and stromal
fibrosis. In patients with AA without metabolic disorders the proliferative potential of epithelial cells (Ki67 proliferation index) was 20–25%, in cases of AA with
metabolic syndrome – 5–10%, indicating a decrease in regenerative capacity of the tissue. The state of the microcirculatory bed (CD31) in cases of AA without metabolic
disorders is more favorable for the trophic tissue function and decreases in the group of AA with metabolic disorders. It was found that activation of pathological cell
apoptosis was observed in cases of AA with metabolic disorders and lower level of bcl-2 expression. In our observations, the level of expression of caspase-3 was at
a relatively high level, indicating the activation of pathological apoptosis in the tissues of the affected areas.
Conclusions: Our pathomorphological, immunohistochemical data allows us to assert that it is advisable to carry out a biopsy of the affected areas with the establishment of
levels of proliferative activity of epithelial and stroma cells, the state of the microcirculatory vessels, the possibilities of repair of the affected areas, assessment of the level of apoptosis in order to predict the course of the disease and usage of the personified approach to treatment.
PHARMACOECONOMIC AND EPIDEMIOLOGICAL BASES OF OPTIMAL ROTAVIRUS VACCINE SUPPLY FOR UKRAINIAN POPULATION
Authors: Soloviov Serhii O. , Mokhort Hennadiy A. , Trokhimenko Olena P. , Zahoriy Hleb V. , Trokhymchuk Viktor V. , Kolesnikova Iryna P. , Dziublyk Iryna V.
Published: November 2020

Introduction: Several studies has shown that rotaviruses play a leading role in the structure of acute intestinal infections (AII) of viral etiology in children. In the National vaccination calendar of Ukraine, vaccination against rotavirus infection (RVI) is classified as recommended, with the expected goal of reducing the number of severe RVI cases among under five-year-old children. Nevertheless, despite the positive epidemiological and clinical effects of vaccination against RVI, it remains unclear how appropriate the introduction of rotavirus vaccines is in terms of potential costs and benefits, as well as determining the optimal level of subsidy required to cover part of the costs of voluntary vaccination of the population. The aim: Study of optimal subsidy level of rotavirus vaccine in Ukraine using epidemiological and pharmacoeconomic modeling. Materials and methods: The retrospective epidemiological data of the monthly RVI incidence in Ukraine as well as the population number from 2010 to 2016 formed the information basis for determining the transmission parameter of the viral agent. The scenario of RVI epidemic process as an acute intestinal infection from the point of view of mathematical epidemiology is best described by developed mathematical model. Cost-benefit of rotavirus vaccination was studied with the use of developed pharmacoeconomic criteria. Results and conclusions: Prediction of possible implications of RVI vaccination and finding optimal level of vaccine supply involves a comprehensive study of the epidemic process peculiarities of this infection with development of an adequate epidemiological model. We have proposed a model of RVI epidemiological process in Ukraine, determining its main parameters with the use of available retrospective data of anual number of RVI cases for the period from 2010 to 2016. The developed model was used as an analytical tool for analyzing influence of different levels of vaccine supply on vaccination cost-benefit. The results of research showed that the use of epidemiological modeling in pharmacoeconomic analysis of rotavirus vaccination made it possible to determine analytically optimal level of vaccination subsidy level.
ADMINISTRATIVE AND LEGAL ENFORCEMENT OF HEALTH CARE: CONCEPTUAL FRAMEWORKS
Authors: Gladchuk Igor , Terzi Olena
Published: November 2020

Introduction: The analysis of the administrative and legal enforcement of health care in Ukraine indicates the lack of sufficient regulatory and legal acts due to the lack of and
deficiencies in conceptual documents, doctrinal developments, strategic planning in this area. The modern administrative-legal management is historically due, since during
the Soviet period health care regulation was determined by the high centralization of governance, the imperative of decision-making, the precise regulation of the activities of its subjects, the lack of overall control and supervision.
The Conceptual Frameworks in this area, as shown by the analysis of scientific literature and legal documents, should include general provisions, goals, objectives, principles, legal framework, subject and object, priority areas of implementation, phases and stages, terms, amount of financial, material and technical resources, expected results.
Each component of the Conceptual Frameworks should be scientifically verified, confirmed by practical experience and statistical data, and also to correspond to the real state of health care in Ukraine. Interconnectivity and intersectionality of the structural parts of the Conceptual Frameworks will ensure its effectiveness.
Penerapan Metode Fuzzy Multi Attribut Decision Making (FMADM) Dan Simple Additive Weighting (SAW) Untuk Penentuan Bujang Dayang Kota Pangkalpinang
Authors: Parlia Romadiana  , Fitriyanti  , Delpiah Wahyuningsih
Published: November 2020

egiatan pemilihan bujang dayang merupakan kegiatan yang rutin dilaksanakan setiap tahun di Kota Pangkalpinang. Pemilihan bujang dan dayang ini merupakan salah satu bentuk pelestarian dan aktualisasi adat budaya daerah Kota Pangkalpinang serta berusaha menampilkan nilai budaya masyarakat yaitu busana tradisional dan tari tradisional sebagai bagian dari nilai budaya yang harus dipertahankan kelestariannya. Dalam penentuan pemenang bujang dayang kota Pangkalpinang, dilakukan beberapa tahapan dalam proses penilaian dimana membutuhkan perhitungan yang akurat agar menghasilkan keputusan pemenang yang sesuai dengan nilai yang sudah dimiliki oleh masing-masing finalis. Dalam proses penentuan pemenang terdapat kendala yaitu lamanya proses perhitungan dalam perangkingan dalam menentukan pemenang bujang dayang kota pangkalpinang karena masih dilakukan secara manual. Dari kendala tersebut, maka peneliti ingin membuat sistem untuk menunjang pengambilan keputusan dalam pemilihan bujang dayang dengan menggunakan metode Fuzzy Multiple Attribute Decision Making (FMADM) dan Simple Additive Weighting (SAW) dimana akan ditentukan kriteria dan bobot sebagai dasar untuk mengembangkan sistem, kemudian membuat variabel dan mengkonversikan ke FMADM lalu dilakukan penyeleksian menggunakan SAW sehingga nantinya akan didapatkan hasil dari pemenang bujang dayang kota Pangkalpinang.
The different forms of COVID-19 misinformation and their consequences
Authors: Enders Adam M. , Uscinski Joseph E. , Klofstad Casey , Stoler Justin
Published: November 2020

As the COVID-19 pandemic progresses, an understanding of the structure and organization of beliefs in pandemic conspiracy theories and misinformation becomes increasingly critical for addressing the threat posed by these dubious ideas. In polling Americans about beliefs in 11 such ideas, we observed clear groupings of beliefs that correspond with different individual-level characteristics (e.g., support for Trump, distrust of scientists) and behavioral intentions (e.g., to take a vaccine, to engage in social activities). Moreover, we found that conspiracy theories enjoy more support, on average, than misinformation about dangerous health practices. Our findings suggest several paths for policymakers, communicators, and scientists to minimize the spread and impact of COVID-19 misinformation and conspiracy theories.
Skystis pleuros ertmėje – diagnostikos problemos
Authors: Valavičius Arvydas
Published: November 2020

Straipsnyje nagrinėjama skysčio pleuros ertmėje problema, diagnostika, stebėjimo ir gydymo principai.
Synthesis of purines and adenines containing the hexafluoroisopropyl group
Authors: Petrov Viacheslav , Dooley Rebecca J , Marchione Alexander A , Diaz Elizabeth L , Clem Brittany S , Marshall William
Published: November 2020

Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding substrates, resulting in the selective alkylation of one of the nitrogen atoms of the imidazole ring. The reaction proceeds under mild conditions in a polar solvent, giving the alkylated products in 47–78% yield. While for purine and 4- and 5-azabenzimidazole, the reaction led to a mixture of two isomers, the reaction of adenine and the corresponding 2-fluoro derivative was regioselective, resulting in the formation of only one isomer in each case. The alkylation of theophylline led to the formation of a new derivative of caffeine.
Examining the Mechanisms Linking Work-Related Conflicts and Employee Well-Being: A Mediation Model
Authors: Kuriakose Vijay , S Sreejesh , Jose Heerah
Published: November 2020

This study examines the role of negative affect state and relationship conflict in explaining the association between two types of work-related conflicts namely, task and process conflicts; and employee well-being. Drawing from affective events theory and social attribution theory, the study hypothesizes a mediation model in which task and process conflicts are negatively associated with employee well-being through negative affect state and relationship conflict. While examining this model, the study establishes the inter-linkage between task, process conflicts and employee well-being and identifies two pathways to explain these relationships. Based on a sample of 554 IT employees from India, the study found support for the mediation model in which negative affect state and relationship conflict mediates the relationship between two types of conflict and employee well-being. Findings of the present study contribute to the theory by extending our understanding of the effect of task and process conflicts on employee well-being and also explains how it impairs well-being. The current insights will help managers and practitioners to design interventions to mitigate the detrimental effect of task and process conflicts on employee well-being.
Examining the Role of Supervisor Support on Generation Z's Intention to Quit
Authors: Chillakuri Bharat
Published: November 2020

The purpose of this research is to examine Generation Z’s unmet expectations and work-related boredom and its impact on their intention to quit. The study investigates the moderating role of the supervisor support in the relationship between work-related boredom and intention to quit. This research advances the understanding of the adverse effects of employees' unmet expectations and work-related boredom. Generation Z joins the organizations with unrealistic expectations of work that, in turn, promote lower levels of commitment and higher turnover, and therefore warrants more research. Data were collected from 336 Generation Z respondents working in the information technology industry. The data were analyzed using least square regressions and bootstrapping techniques. The findings confirm that supervisor support moderates the relationship between work-related boredom and employees’ intention to quit such that if the degree of supervisor support is higher, then the relation is weaker. HRM practitioners need to be candid in explaining the job description and job specifications during the interview; more importantly, organizations need to address the expectations even before they are hired. The findings indicate that high supervisor support buffers the adverse effects of unmet expectations and work-related boredom. The study suggests that coaching could be an effective tool to support Generation Z’s aspirations and well-being in the workplace. Therefore, organizations should make coaching a key element in the organization’s culture and part of a manager's job.
Flora of Singapore precursors, 19: Nomenclatural notes on Artabotrys (Annonaceae) and Magnolia (Magnoliaceae)
Authors: Chen J. , Baldini R.M.
Published: November 2020

During the preparation of the accounts of Artabotrys (Annonaceae) and Magnolia (Magnoliaceae) for the Flora of Singapore, the types of all relevant names were evaluated. New lectotypes are designated for A. suaveolens and M. maingayi and a second-step lectotypification is performed for M. elegans. The citation of a lectotype locality is corrected for A. costatus and the citation of an isolectotype is improved for A. maingayi. We also clarify the previous use of the term ‘type’ to designate specimens that are in fact lectotypes for several names in Magnolia.
Science and Festivity. The Cult and Idealization towards the Images of St. Cyril and Methodius and Some of their Students in Some Countries in the Black Sea Region during 1945-1990
Authors: Azmanova-Rudarska Elena
Published: November 2020

This paper follows the cult towards some of the St. Holy Seven Saints - St. Cyril, St. Methodius, St. Klement and St. Naum. The accent falls on countries like Bulgaria, Russia, Romania, Ukraine, Moldova, Turkeу and others. Scientific, as well as festivе manifestations are being reviewed during the anniversary years 1963, 1966 and 1969, and different scientific meetings, conferences and simposiums, which show the cult in new light. On one hand the article takes into account the scientific achievements from the middle of the 19th century until 1945, and on the other - after the Second World War. Known facts and hypotheses are being ideologized or moved aside, so that the new political landmarks can be emphasized. During these scientific forums Bulgaria was considered as a bridge between the East and the West.
„You Do Not Hear The Cry of the People to Whom You Owe So Much…“: The Image of the Bulgarians in Russian Pan-Slavism of the 19th Century
Authors: Kasatkin Konstantin
Published: November 2020

In the 19th century, the idea of Pan-Slavism was widespread among the Slavic nations. However, the very concept of Slavic reciprocity had different connotations in various fields of culture. The ‘imperial’ or ‘Russian’ Pan-Slavism that became wide-spread in Russia was characterized by identification of interests of all Slavism with the interests of the Russian politics. It began to form in the 1820s and developed mainly on the basis of the South Slavic material. At the same time, the Bulgarians were the focus of ‘imperial’ Pan-Slavic theories. Through the example of works by Y.I. Venelin, A.F. Veltman and I.P. Liprandi, this paper traces the process of gradual transformation of the Bulgarians into one of the key elements of the ‘Russian’ Pan-Slavic theories of 1820-1870s. For a long time, the fantasies of Pan-Slavists found no response among the political elites. However, the situation changed radically after the Crimean War. The ideas about Russian-Bulgarian reciprocity expressed by Venelin formed the core of the theory of imperial Pan-Slavism and, thanks to state and near-state figures like Liprandi, they became an integral part of the Russian policy in the Balkans in the second half of the 19th century.
Linguocognitive Aspects of the Dynamic of Verbalisation the Conceptial Space „Trade“
Authors: Kolesnik Valentina , Yarotskaya Galina
Published: November 2020

The article explores systemic lingual and speech facts objectifying trade, which are fixated in lexicographical sources. Comprehensible, exemplary, and values-based characteristics of trade are established. This establishment allows the discussion of the fact that in the commonplace, economic consciousness of a native speaker of the Russian language and Russian linguaculture, the following notional components of the logico-rational conceptualization of trade are present (evidently or not evidently): 1) entrepreneurship; 2) buying-selling, circulation of products; 3) obtainment of advantages. Figuratively-evaluative components of the conceptualization characterize trade as an activity which entails betrayal and deception, unfair profits and “lucre” (barysh), which allow discussion of the presence of (evidently or not evidently) the following notional components of the logico-rational conceptualization of trade in the commonplace economic consciousness of a native speaker of Russian and linguaculture: 1) entrepreneurship; 2) buying-selling, circulation of products; 3) obtainment of profits.Values-based components are presented in an aphorismic representation, mutually excluding normative judgements related to trade links and theft, truthfulness and lies in a product’s commercial, business and familial ties in bargaining, necessity of obtaining a profit while at the same time retaining moral values. The defining characteristic of the perception of a bargain situation is the presence of mutually exclusive norms of behavior during the buying and selling of products: deceiving is forbidden and allowed, familial ties are taken into account and ignored, there is and there is not a link between trade and theft. These contradictions can be explained with famous cultural dominations in Russian lingual consciousness: the necessity of living according to the laws of higher justice and the resulting maximalism in the evaluation of the reality of life, and thus negative evaluation of the material enrichment of individuals. Logico-rational conceptualizations of trade in lingual consciousness identify the following peculiar qualities: 1) thorough linguocognitive elaboration on the name of the salesperson in the form of several nicknames, given to the salesperson depending on the produced and realized product, 2) conceptual (and associative) connections between the lexeme to sell and resell, buy and bribe, 3) unification of semantic characteristics in the words “producer” and “seller of product” in one nomination, which negates the presence of commercial, trade activity as mediation, 4) negative evaluation of aspiration to unfair advantages (barysh) and 5) presence of mutually exclusive behavior norms during bargaining.
Language of Science – Language of Translation
Authors: Aroshidze Marine , Aroshidze Nino
Published: November 2020

Modern civilisation processes, which are closely interrelated with cultural and linguistic globalisation, have entered the era of the noosphere; humanity is encountering these problems at present, the solution to which requires joint efforts and a high level of knowledge about globalisation. However, for a constructive dialogue amongst all nationalities within the framework of the world community and the achievement of a "knowledge society", it is necessary to understand the functioning of a world language, the peculiarities of intercultural communication, the originality of national ideas of the world, and the ideological concepts conveyed in natural languages; thus, the language of science and of scientific thinking is of particular importance in terms of the target language.The choice of the language of science, which must fulfil all the functions assigned to it, is determined by a complex socio-political conditions; otherwise, we would have an intermediary language, a translation language, or a language of cognitive thinking. A review of the change in the languages of science in the post-Soviet space (in the example of Georgia) allows us to assert that only the harmonious development of a global language within the national languages of science can provide a multifaceted reflection of reality and the dynamism of the development of science.
The Legacy of the First World War in the Transcaucasia from the perspectives of the New Humanities
Authors: Gotsiridze George
Published: November 2020

The work discusses the legacy of the First World War - its positive and negative sides - which played an important role in the formation of the world processes in the post-war period and still preserves its viability.The actuality of the problem is backed by the fact that the relationship of the Transcaucasian countries with the outer world is still problematic nowadays. We witness how the world’s political and economic map is changing and technical-scientific progress is tangible. In the conditions of the accelerated global processes, a general political, economic and cultural area is being formed, and a new world order is being formed with its difficulties, social catastrophes or cataclysms, conflicts, divergence and integration. At this time, it is of utmost importance to analyze historical problems from the past and seek ways to resolve them in the political relations of the South Caucasus, as in their attitude towards the outside world, under-standing that unity is a necessary guarantee of strengthening the statehood of each country and that the perception of the Transcaucasia the rest of the world as a unified political and economic sphere will simplify the Euro Atlantic integration. The issue is discussed from the new humanitarian perspectives, which gives us the opportunity to determine the national verticals from experience received centuries ago, around which local or regional political consciousness should be unified in order to satisfy the national interests of each country in the Transcaucasia through closer cooperation.