bluuebunny/crossref_metadata_2025 huggingface dataset:
The ethical dilemma of medical specialists in the era of national health insurance in Semarang
Authors: Sigid Kirana Lintang Bhima  , Yayi Suryo Prabandari  , Limijadi Edward Kurnia Setiawan , Astika Utomo  , Laila Mubarokah  , Mohammad Hakimi
Published: May 2024

Purpose: The National Health Insurance (JKN) implemented by the Indonesian government since 2014 has brought Indonesia to a new phase in realizing the right to health for its people. The social insurance system managed by Social Health Insurance Administration Body (BPJS) is felt to bring many benefits to the community despite many obstacles in its implementation. This study seeks to find the ethical dilemmas experienced by surgical and non-surgical specialists in implementing the JKN program in hospitals.
Methods: The study was conducted using the qualitative method with the phenomenological approach by conducting in-depth interviews with five surgical specialists (an obstetric and gynecology, an otolaryngologist specialist, a surgeon, an eye specialist, and an anaesthesiologist) and six non-surgical specialists (children, mental health, internal medicine, medical rehabilitation, nerves, and skin specialists) in Semarang, Indonesia. In each specialization, there are two respondents interviewed. The data were analyzed using a qualitative approach.
Results: Some problems still exist when specialist doctors treat BPJS patients in hospitals, which include: 1) lack of socialization, making doctors as implementers find it difficult to implement the rules; 2) different implementations in various hospitals, making doctors find it difficult to adjust when they practice at type C hospitals because the number of claims is often insufficient to provide services to patients; 3) the JKN program that has increased the number of patients, resulting in doctors' concerns about lawsuits if they make mistakes; moreover, doctors also have to adjust to existing cost claims; and 4) doctors still trying to uphold the doctor's oath and The Indonesian Medical Ethics Code (KODEKI) and always do the best for patients whatever the problem. Conclusion: The implementation of JKN must always be evaluated continuously, and the government still has to pay attention to the obstacles faced by doctors in the field. In carrying out their practice full of dilemmas, doctors must always receive adequate legal and ethical protection.
The influence of social media on the treatment and psychosocial of acne vulgaris patient
Authors: Kristin Stephanie  , Nelva Karmila Jusuf  , Imam Budi Putra
Published: May 2024

Introduction: Many social media platforms are available today that can facilitate social interaction and potentially affect health behavior. Social media can potentially serve as a source of information about how to treat acne. They can also be a tool to compare and raise dissatisfaction with their body image. Acne is a skin condition that primarily affects the face and can lead to significant psychosocial effects.
Methods: This study was a descriptive observational study with a cross-sectional design that included 50 subjects with acne vulgaris according to inclusion and exclusion criteria. Basic data were recorded, including age, gender, education and job. Social media usage data were recorded, including actively used social media platforms and duration of use. Acne vulgaris treatment used by the subject based on information obtained from social media was recorded. Psychosocial was assessed using Acne-QoL-INA and Rosenberg Self-Esteem Scale questionnaire.
Result: In this study, acne vulgaris was more common in women and the 18-25 age group, where most subjects had higher education and student group. Instagram was the social media used daily by most acne vulgaris patients. Instagram was also the most used social media to access regarding therapy for acne vulgaris and was mostly used 1 hour per day. The subject used skin care to treat their acne, followed by topical agents and practicing instruction to heal acne. The influence of social media on the quality of life showed the lowest score range (0-10) on self-perception, role-social and role-emotional domain, on the acne symptoms domain was in the middle score range (11-20). Social media's influence on self-esteem shows 6% on low self-esteem, followed by 94% in the normal score range.
Conclusion: Using social media could encourage patients with acne to seek self-medication, mostly use skincare and have a psychosocial impact on patient's quality of life.
The effect of Chromolaena odorata on endometriosis implants in mice model of endometriosis
Authors: Rusnaidi  , Rajuddin  , Kamarlis Reno Keumalazia , Dasrul
Published: May 2024

Introduction: Endometriosis is a benign gynecological disease whose pathogenesis mechanism is not fully understood with treatment modality with hormonal and surgical methods aiming to relieve symptoms, suppress progression, and increase fertility. This study aims to observe the differences in the administration of Chromolaena odorata leaf extract on the area of endometriosis implants in the mice model of endometriosis
Materials and Methods: This study was an experimental study with a Randomized Separated Pre and Post Test Design research conducted with the control group. Thirty mice (Mus musculus) were injected with 0.2 ml/mice of cyclosporine A. Then endometrial tissue was injected into the peritoneal cavity, followed by 0.1 ml Ethinyl estradiol/mice injections on the 1st and 5th days. Mice were reared for 14 days until the endometriosis model was formed. Mice models of endometriosis were randomly divided into five groups: endometriosis mice that were terminated on day 14 (pretest), then the other groups are endometriosis mice given Aquadest as placebo (P0), endometriosis mice treated with Chromolaena odorata leaf extract at a dose of 400 mg per kilograms of body weigh (mg/kgBW) (P1), 800 mg/kgBW (P2) and 1200 mg/kgBW (P3) for 14 days. On the twenty-eighth day, mice were dissected to examine and assess the extent of endometriosis implantation macroscopically in hyperemic areas by taking samples in the most hyperemic areas of the peritoneal wall. Research data were analyzed using SPSS Version 22.
Results: From this study, the average value of endometriosis implant area in the group given Chromolaena odorata leaf extract was 400 mg/kgBW (P1 = 15.60 mm2), 800 mg/kgBW (P2=14.23 mm2) and 1200 mg/kgBW (P3=0.00 mm2) was lower than the pretest group (P=104.72 mm2) and the placebo group (P0 = 153.89 mm2), showing a significant difference (p<0.001). There was a tendency that the area of endometriosis implants was also lower in the group receiving a higher dose of Chromolaena odorata leaf extract 1200 mg/kgBW (P3=0.00 mm2) than the group receiving a dose of 400 mg/kgBW (P1=15.60 mm2) and 800 mg/kgBW (P2=14.23 mm2).
Conclusions: It can be concluded that the administration of Chromolaena odorata leaf extract can reduce the area of endometriosis implants in mice models of endometriosis. Higher doses result in the lower endometrial implant area.
Effects of diabetes mellitus regulation on antibody response to inactivated virus vaccine: a systematic review
Authors: Prasetyaningtyas Dewi , Soegiarto Gatot , Wulandari Laksmi
Published: May 2024

Background: Diabetes mellitus (DM) could hamper the immune responses, including that induced by the vaccine. The aim of this study was to evaluate the immunogenicity of coronavirus disease 2019 (COVID-19-19) inactivated vaccines in patients with DM either controlled or uncontrolled through a systematic review approach.
Methods: Without regard to time constraints, searches were conducted in ProQuest, Embase, and PubMed  to assess the available data on the impact of DM regulation on the immunogenicity of post-vaccinated DM patients. The PRISMA guideline and the PICO criteria were used. The quality of studies was assessed using the National Institutes of Health (NIH) quality assessment tool. There is not enough Available data comparing the immunogenicity of the vaccine in controlled and uncontrolled DM patients is limited.
Results: Out of 20,657 articles, five studies were included, of which three had good quality and two had fair quality. Our data suggested that DM patients vaccinated with CoronaVac/SinoVac had lower seroconversion rates significantly lower compared to non-DM patients. The immunogenicity of BBV-152 vaccine in DM patients was also significantly lower than in patients without DM. Studies comparing the immunogenicity of the vaccine between controlled and uncontrolled DM patients are limited.
Conclusion: Patients with DM have lower antibody levels than non-DM patients who received inactivated COVID-19 patients. Glycemic management has emerged as critical to maximizing the immunogenicity induced by inactivated vaccines in a small number of patients; however, to support this conclusion, studies with adequate number of patients are critical.
Cryptococcal meningoencephalitis in an immunodeficiency virus positive patient coinfected with tuberculosis
Authors: Wirantara Hendy , Rusli Musofa , Arfijanto Muhammad Vitanata , Bramantono
Published: May 2024

Background: Cryptococcal meningitis is an inflammation of the meninges due to Cryptococcus fungal infection which commonly invades people living with immunodeficiency virus (PLHIV) with impaired immunity. The disease has a high mortality rate and is frequently misdiagnosed in the early stages due to vague symptoms. This case report aimed to provide information regarding diagnosing and managing cryptococcal meningoencephalitis in patients with acquired immunodeficiency syndrome (AIDS) and tuberculosis.
Case presentation: We reported a case of 34-year-old woman that complained of headache and fever from one month ago. There were also oral white patches in the last two weeks. The patient was diagnosed with lung TB and human immunodeficiency virus (HIV) in February 2021, but the TB was just being treated in the past two months and HIV in last two weeks. Head CT-scan with contrast showed meningoencephalitis, brain edema, left frontal, left ethmoidal, left and right maxillary and left sphenoid sinusitis. On the 9th day of hospitalization, the patient had seizures. Analysis of the cerebrospinal fluid culture revealed Cryptococcus neoformans. The patient’s comorbidities were leucopenia, hypoalbuminemia, pneumonia, brain edema which led to poor prognosis. On the 10th day, the seizures relapsed, followed by the drastically reduced SpO2 and death. Septic shock and multiorgan failure were considered the cause of the case's death.
Conclusion: This case highlights the importance of early diagnosis and management to avoid unfavorable outcome.
Anxiety and perceived mental healthcare need among non-frontline in coronavirus referral hospital, Surabaya
Authors: Wijono Heru , Melaniani Soenarnatalina , Kuntoro  , Zakaria Zainul Amiruddin , Oka Made , Bte Marmaya Najihah Hanisah , Ikawaty Risma , Saputra Bagus Ida
Published: May 2024

Link of Video Abstract: https://youtu.be/szoOkhYlQwY
 
Introduction: The pandemic of COVID-19 has put healthcare workers under high pressure with possible psychological problems and its most common effects are insomnia, depression, distress, anxiety, and somatization symptoms. Previous studies in several centers have shown different results between frontline and non-frontline healthcare workers. This study aims to evaluate the levels of anxiety and perceived needs for mental healthcare among non-frontline healthcare workers during the COVID-19 pandemic in a referral hospital in Surabaya.
Patients and methods: This cross-sectional study involved forty respondents, but one was discontinued due to technical problems. Questionnaire of The Hospital Anxiety and Depression Scale (HADS) was adopted that has 14 scales with two subscales. The subscales include HADS-A for Anxiety and HADS-D for depression
Results: The results show that both HADS-A and HADS-D have significant differences between the indirect and direct groups of contact healthcare workers, except in gender and depression, as shown in Table 3, with an average score of 8.000 (SD 5.02169) and 8.7333 (SD 4.71270), respectively.
Conclusion: Anxiety and depression remain a problem for all healthcare workers, whether frontline or non-frontline. Therefore, issues must be used to mitigate both the frontline and non-frontline healthcare workers.
Evaluation of hearing limits post tympanoplasty in patients with chronic suppurative otitis media
Authors: Probosutejo Nico , Ahadiah Titiek Hidajati
Published: May 2024

Link of Video Abstract: https://youtu.be/Nr9MKgu2v2E
 
Background: Chronic suppurative otitis media (CSOM) causes partial or complete damage to the tympanic membrane and ossicles, causing hearing loss in the form of conductive and mixed hearing loss with a decrease of up to 60 dB. This study aimed to evaluate the hearing threshold before and after tympanoplasty surgery in CSOM patients.
Methods: This type of research was carried out in a retrospective descriptive manner. The materials in this study were the medical records of CSOM patients who underwent canal wall up (CWU) tympanoplasty and canal wall down (CWD) tympanoplasty at the outpatients of ear, nose, and throat – head and neck surgery (ENT-HNS) Otology Division Dr. Soetomo Hospital Surabaya for the period January 1, 2018 to December 31, 2018 with a total of 51 patients. This study analyzed with the Wilcoxon test.
Results: The mean age was 30.96 years (51% female and 49% male). Postoperatively 40 (78.5%) patients experienced an increase in hearing threshold, 10 (19.6%) patients experienced a decrease and 1 (1.9%) patient remained. The average increase in air-bone gap (ABG) pre and post tympanoplasty surgery was 9.78 dB, from 38.92 dB to 29.14 dB.
Conclusion: There was an increase in hearing threshold after tympanoplasty.
LOX-1 rs1050283 TT genotype is associated with the severity of peripheral artery disease: a cross-sectional study in Mataram, Indonesia
Authors: Indrayana Yanna , Yusuf Irawan , Bukhari Agussalim , Mappangaro Idar , Harahap Herpan Syafii
Published: May 2024

Background: Peripheral arterial disease (PAD) is an important consequence of atherosclerosis commonly determined based on the results of ankle-brachial index (ABI) measurements. Due to its limitations, the search for potential predictors of PAD severity is ongoing. Serum soluble Lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels and LOX-1 polymorphism rs1050283 are candidates for predictors of PAD severity. This study aimed to investigate the association between the LOX-1 rs1050283 TT genotype and the severity of PAD.
Methods: This cross-sectional study involved PAD patients recruited consecutively. The patients were genotyped for rs1050283 (3’ UTR C>T) LOX-1 single nucleotide polymorphism using the sequencing method. Serum sLOX-1 levels were measured using ELISA. Data on ABI were collected, and the patients were categorized into mild and moderate to severe PAD groups.
Results: A total of 66 PAD patients with a mean age of 58.9 years participated in this study, which consisted of 45 patients with mild PAD and 21 patients with moderate to severe PAD. Multivariate logistic regression analysis showed that the TT genotype was associated with PAD severity compared to those with the CC genotype (odds ratio (OR): 15.0, 95% confidence intervals (CI): 1.1 – 209.0), while higher serum sLOX-1 levels were not. PAD severity was also associated with increasing age (OR: 5.7, 95% CI: 1.3 – 25.7) and male gender (OR: 6.0, 95% CI: 1.1 – 32.2).
Conclusion: TT genotype of LOX-1 rs1050283 polymorphism was associated with PAD severity, whereas higher serum sLOX-1 levels were not. In addition, increasing age and male gender were also associated with PAD severity.
Platelet count, platelet lymphocyte ratio, and Ki67 as a predictive factor of neoadjuvant chemotherapy response in locally advanced breast cancer
Authors: Priyono Sasongko Hadi , Badriatunnor  , Meitria Syahadatina Noor  , Agung Ary Wibowo  , Didik Dwi Sanyoto  , Audi Ardansyah
Published: May 2024

Link of Video Abstract: https://youtu.be/CjzggoIFnTU
 
Background: Locally advanced breast cancer (LABC) is a term that refers to advanced non metastatic stage breast cancer. Neoadjuvant chemotherapy is one of the therapies given to patients with LABC. Many factors can affect the chemotherapy response, platelets produce growth factors, and cytokines promote angiogenesis and tumor growth. Inflammatory biomarkers such as platelet lymphocyte ratio (PLR) may indicate tumor progressiveness. The Ki67 proliferation index is a marker of the aggressiveness or growth of tumor cells. This study aimed to determine the correlation of platelet count, platelet lymphocyte ratio and Ki67 proliferation index before chemotherapy with neoadjuvant chemotherapy response.
Method: This research used the cohort retrospective design method. A sample of 155 patients was selected using a simple random sampling technique. The inclusion criteria of this research are having complete data about pre-treatment platelet, lymphocyte platelet ratio, Ki67 and the neoadjuvant chemotherapy response result assessed by the oncologist that is written in the medical record. Patient data from other types of cancer, chronic, systemic or autoimmune diseases are excluded from this research. The data of each variable was analyzed with the Spearman correlation test.
Result: There was no correlation between platelet count and neoadjuvant chemotherapy response (p=0.301). There was a negative correlation between the platelet lymphocyte ratio (p=0.026) and the Ki67 index (p=0.040) with neoadjuvant chemotherapy response.
Conclusion: Based on this study, it can be concluded that platelet count is not significant in relation to chemotherapy responses. The higher the platelet lymphocyte ratio and the proliferation index of Ki67, the lower the response to neoadjuvant chemotherapy.
Characteristics of patients with nasopharyngeal carcinoma in Dr. Soetomo General Academic Hospital Surabaya
Authors: Utomo Audi Wahyu , Romdhoni Achmad Chusnu
Published: May 2024

Link of Video Abstract: https://youtu.be/vwaMtqzZyI0
 
Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor in the nasopharynx with a high incidence of metastasis. NPC is one of the most common cancers in Indonesia, and from the age distribution, it often affects the productive age population. This study aims to describe the characteristics of NPC patients in Dr.Soetomo General Academic Hospital from January 2017 – December 2018.
Methods: This study is a retrospective descriptive by taking medical records of patients with NPC at Dr. Soetomo Hospital, Surabaya, from January 2017-December 2018, that meet the inclusion and exclusion criteria. The basic data taken are gender, age, education, and occupation. Complaints assessed are the main complaints of patients who make patients come for treatment listed in the medical record data.
Results: Data from 262 patients showed that the five-year life expectancy for NPC sufferers in women is 84%, while in men, it is 78%. The main complaints of patients in this study were lumps in the neck in 130 patients (49.61%), with the highest distribution of patients based on stage IV a with 78 patients (29.77%), and the majority were non-keratinizing carcinoma undifferentiated type, with a total of 245 patients (93.51%).
Conclusion: Male sufferers are more than females; the largest age group is 41-50. Most jobs are private employees, and most sufferers' last education is high school. The main complaint of most patients was a lump in the neck, and the patient came with an advanced stage where the most found was stage IV. The histopathological type of most patients is non-keratinizing carcinoma undifferentiated type.
A novel solution for the patient with knee ankylosing spondylitis: a case report
Authors: Argo Risang Setyo , Kennedy Dave , Usman Muhammad Andry
Published: May 2024

Link of Video Abstract: https://youtu.be/wskQdvBx0c0
 
Background: Knee ankylosis is a joint condition that causes functional limitation that becomes more severe when accompanied by pain. Arthroplasty is a complex and intricate reconstruction procedure that is more challenging when there is a structural limitation that requires a technique modification. In this report, we presented a rare case of a young patient with knee ankylosis and flexion contracture treated with arthroplasty.
Case Presentation: A 20-year-old young woman came to the hospital with stiffness in her left knee, inability to sit well and crouch, and difficulty getting up from sitting. Based on the physical examination and X-ray of the left knee, the patient showed bone ankylosis on the femorotibial joint with a 100 flexion, which confirmed knee ankylosis. Arthroplasty was performed with a parapatellar medial approach. After eight months of supervision, the patient was able to perform an active flexion within 1050 and a full extension on the left knee. In our patient, arthroplasty brought a satisfying functional outcome and pain reduction, which was also supported by previous studies with the same procedure on ankylosis patients.
Conclusion:  Arthroplasty can be considered the main therapy option for joint deformities due to its more satisfying outcomes.
Relationship between hypoxia inducible factor-1 alpha (HIF-1α) levels and cellulite
Authors: Fovina Angela , Jusuf Nelva Karmila , Putra Imam Budi
Published: May 2024

Link of Video Abstract: https://www.youtube.com/watch?v=ePouj9BkVdg
 
Background: Cellulite is a topographic change of the skin surface, characterized by an appearance like orange peel, mattress or cottage cheese, especially on the buttocks and hamstrings. Cellulite is a process that starts from adipocyte hypertrophy and dermal vascular damage, especially loss of the capillary network. Loss of the capillary network will cause the dermis and subcutaneous tissue to retain fluid, inhibiting venous return and causing swelling, ischemia, and hypoxia in the subcutaneous tissue. When hypoxia occurs, cellular adaptive processes activate hypoxia-inducible factor (HIF). Hypoxia-inducible factor-1α will interact with enzymes and other transcription factors to maintain homeostasis by increasing vascularization and tissue growth in acute hypoxic conditions. However, in chronic hypoxic conditions, HIF-1α can cause detrimental effects such as excessive extracellular matrix development resulting in tissue fibrosis. This study aims to determine the relationship between HIF-1α levels and cellulite.
Methods: This observational research included 40 cellulite patients and 40 controls in a cross-sectional design. Each patient got a medical history check, a dermatological exam, and blood testing to determine their HIF-1 levels using an ELISA test. The Chi-square test was used to statistically analyze these statistics.
Results: The mean HIF-1α level in cellulite was 5.74±2.39 ng/ml. The highest age with cellulite was 26–33 years, consisting of 12 (30%) people. Most of them had a family history of cellulite from their mother, consisting of 15 (37.5%) people. Nineteen (47.5%) of them were obese. Most cellulite is located on the femoral and gluteus regions in 27 people (67.5%). The result of this study showed that there was a relationship between high HIF-1α levels causing a risk of 4.8 times for cellulite (p=0.002).
Conclusion: There is a relationship between HIF-1α levels and cellulite.
Relationship between waist hip ratio index and photonumeric cellulite severity scale on cellulite
Authors: Lubis Ade Fitriyani , Jusuf Nelva Karmila , Putra Imam Budi
Published: May 2024

Link of Video Abstract: https://youtu.be/ytotD9AJQPE
 
Introduction: Cellulite is one of many alterations in the physiology of the skin that obesity is linked to. Waist circumference measurement, in addition to body mass index (BMI), is another method for identifying obesity and assessing the risk of disease associated with body weight. The waist hip ratio (WHR), which is calculated by adding the measurements of the waist and hips, is a tool for identifying the kind of obesity. We sought to ascertain how the WHR index and PCSS related to cellulite.
Method: Based on inclusion and exclusion criteria, this study was an observational analytical study using a cross-sectional methodology with 40 female cellulite patients. Age and family background were noted. A measuring tape was used to determine the WHR index value. The PCSS scale is used to assess the severity of cellulite. Gamma correlation analysis was used to examine the link between the WHR index and PCSS; a relationship was considered significant if the p-value was less than 0.05.
Results: Cellulite occurs more frequently in women aged 26–35 years (37.5%) who have a family history of cellulite (82.5%) and WHR index values ≥ 0.85 (45%) with a mild degree of severity based on PCSS, totalling 20 people (50%). The findings of the study revealed a significantly positive association (p<0.05) with a very strong strength between the WHR index and PCSS (r=0.94).
Conclusion: The WHR index and the PCSS for cellulite have a very strong association.
A Stevens-Johnson syndrome due to rifampicin in a patient with acquired immune deficiency syndrome (AIDS) and pulmonary tuberculosis
Authors: Aninditya Aiza Dwitri , Baskoro Ari
Published: May 2024

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially fatal hypersensitivity reactions that can be drug-induced, especially in patients with AIDS. This report aims to highlight the diagnosis and management of a patient with acquired immunodeficiency syndrome (AIDS) that consumed multiple drugs including anti-tuberculosis drugs that develop SJS.
Case presentation: A 30-year-old male patient with AIDS administered with chief complaints of burning sensation all over the bodies and erythematous macules scattered across the stomach and back, followed by blisters distributed across the chest, back, face, lips, hands and feet, as well as genitals for 3 days. Patient was diagnosed with AIDS and under ARV medication since about 5 years ago and dan cotrimoxazole for 9 months. Couple months before admission, patient was diagnosed with tuberculosis and under anti-tuberculosis treatment (isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE)) but stopped due to drug-induced hepatitis (DIH) which then changed to another regiment (streptomycin, levofloxacin, and ethambutol (SLE)) followed by another regiment (rifampicin, isoniazid and ethambutol (RHE)). The patient diagnosed with drug-induced SJS, however, in order to find out the SJS drugs inducer, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis (ALDEN) score as causality assessments tool was applied and rifampicin decided to be the precursor. The patient was managed for 13 days prior to discharge with improved condition.
Conclusion: Diagnosing process for drug-induced in patient with AIDS, in addition to multiple drugs consumption, is a challenge. A multidisciplinary approach and appropriate causality assessments tool should be considered before administering further management and medications.
Nocturia Overview: a survey from General Practitioners in Indonesia
Authors: Indraswari Madhyra Tri , Rahardjo Harrina Erlianti
Published: May 2024

Link Video Abstract: https://youtu.be/5cvWJq-8s0w
 
Background: Nocturia is the need or the number of waking up at night to urinate, with each void preceded and followed by sleep. It is included in lower urinary tract symptoms and reported as the most bothersome and common. Nocturia causes long term sleep deprivation and lowers someone's quality of life. Thus, they need to know how to diagnose and treat nocturia, including time to refer to a specialist. This study aims to review the management and diagnosis of nocturia among Indonesian general practitioners.
Methods: This study used cross sectional design. The data was collected by distributing a self-made online survey with Google Forms about the overview of nocturia among general practitioners in Indonesia, taken from October 2021 to March 2022. Data were analyzed using SPSS version 20.0 for Windows.
Results: There were 252 participants in this study that filled in the questionnaire from October 2021 to March 2022. Most patients (57.8%) were between 50 and 65 years old. Different approaches for nocturia were made, with mainly chose education and lifestyle change (88.1%) and medication such as alpha blocker (19.8%) compared to desmopressin (13.5%). Only 65.5% of respondents referred their patients to urologists for further therapy.
Conclusion: General practitioners in Indonesia face difficulty in dealing with nocturia. It is better to refer these patients to a urologist or other related specialist after they perform the diagnostic examinations and standard therapy.
Workplace interventions to overcome stigma and depression in patients with Multiple drug-resistant tuberculosis (MDR TB)
Authors: Mawey Feytie Magda , Karimah Azimatul , Kusmiati Tutik
Published: May 2024

Introduction: MDR-TB is an infectious disease that can cause death and stigma for those infected. MDR-TB patients with depression are at risk for LTFU, which will worsen their condition and strengthen the stigma they receive.
Case report: A 52-year-old female psychiatric interview and assessment using the Beck Depression Inventory (BDI) found that BDI score of 4 (no depression), and the patient adhered to TB treatment. She was found to be laid off, and an assessment using the BDI to detect depression in the patient found potential stigma in the patient, such as being laid off from work, prohibited from teaching face-to-face, and shunned by colleagues. Interventions given were prescribing Fluoxetine 20 mg per day and Clobazam 10 mg per day, a brief intervention using the FRAMES technique, psychoeducation about disease and drug effects and the duration of treatment, and an office visit. A worksite intervention was performed by the patient's husband. Antituberculosis drugs were monitored by both a pulmonologist and a psychiatrist. Her work-related problems were resolved through interventions at the school with psychoeducation about drug-resistant tuberculosis, the transmission method, the duration of treatment, and the side effects of the treatment. The results of the last sputum examination after one month of treatment showed drug resistance, and the patient was advised to undergo 18 months of treatment. The patient could finally work offline with fewer responsibilities after getting negative laboratory test results twice in a row.
Conclusion Work-related psychosocial interventions are required to address rejection at work, which results in depression and nonadherence to treatment. Liaison services with social interventions at work in drug-resistant tuberculosis-infected patients are necessary to improve their quality of life and maintain their treatment adherence.
The effect of bisphosphonate and platelet-rich plasma in anterior cruciate ligament reconstruction: an article review
Authors: Sibarani Tangkas , Purwanto Bambang , Mudigdo Ambar , Wasita Brian
Published: May 2024

Link of Video Abstract: https://youtu.be/fn9kA601YVo
ACL rupture is a common injury often resulting from previously healthy individuals' non-contact knee injuries. ACL rupture in young adults and teenagers are becoming more common, contrary to earlier theories that suggested ACL damage was uncommon in skeletally immature people. This risk is significantly raised by concomitant meniscal injury whether or not an ACL reconstruction is undertaken. Although surgical management with allograft or autograft reconstruction can be achieved successfully, there are some serious complications following ACL reconstruction. The supply of autografts is limited, especially in situations with numerous ligament injuries or re-ruptures, which might result in morbidity at the donor site. Allografts can increase the spread of illness and trigger an inflammatory response, which is a drawback. There has been much interest in a tissue-engineered ACL graft because of these issues and current developments in bioengineering and regenerative medicine. According to recent research, following an ACL repair, the bone marrow density surrounding the knee area diminishes. Platelet Rich Plasma (PRP) and Bisphosphonate are the substrates that could ameliorate this phenomenon.  Therefore, this review aims to compile evidence of PRP and bisphosphonate and its effect on the tendon-bone interface in ACL reconstruction.
A review of fit to work assessment program on the work performance of heavy equipment operators during the pandemic covid-19 at Indonesia
Authors: Ayu Friska , Nourma Muslikha , Sahri Moch , Hutapea Octavianus , Winarno Bondan
Published: May 2024

Introduction: Fit-to-work assessment is one of the health examination efforts to assess the physical function and occupational health of workers before starting work. This fit-to-work assessment is very important during the current pandemic because the workplace is a place that is at risk of transmitting the COVID-19 virus, especially a workplace that continues to operate during the pandemic. Thus, this study aims to analyze the influence of fit-to-work assessment on the work performance of Heavy Equipment Operators at a port service terminal in Indonesia during the COVID-19 pandemic.
Methods: The type of research used descriptive analytics with the cross-sectional study. The sample was collected with a simple random sampling technique. The population in this study is heavy equipment operators in one of the sub-holding of PT. Pelindo Terminal Petikemas Surabaya- Indonesia with a sample of 54 operators who can represent each work shift. Each participant was given a questionnaire and needed to fulfill it. The data will be analyzed using SPSS 25. The data analyzed was descriptive only.
Results: According to the study of the characteristics, mostly the ages were 31-40 (46.30%), with a high prevalence of high school (76%). The work shift schedule was classified into three parts. Shift two from 3.30 pm until 11.40. The length of work was also more than five years or greater than others (59.25%), with the work performance from 54 respondents, we found that they had a high work performance (72%), and all of the respondents were mostly in a reasonable condition (94.04%).
Conclusion:  Fit-to-work assessment is carried out before work to determine whether the worker is fit or unfit to work according to the level of health required. The work performance we found that mostly they have a high work performance. It was also in line with the fit-to-work assessment results that most respondents were in a reasonable condition.
Health profile of batik workers in Malon Village Indonesia
Authors: Widowati Evi , Kurnia Arif Rahmat , Yuliati  , Maretta Yoris Adi , Lestari Puji , Kurniawan Muhammad , Cahyati Widya Hary
Published: May 2024

Background: The making of batik in Malon Village utilized natural dyes. The process of making batik was done through 7 stages: designing pattern, tracing, outlining, coloring, fixating, masking and rinsing. Those processes were conducted with poor ergonomic working positions and were highly potential to cause injury for the batik workers. This study aimed at finding out the potential health risks that exist for the natural batik workers and the occupational health profiles of batik workers in Malon Village which is an icon for naturally dyed batik.
Method: This study was descriptive quantitative research by using observational design. The data were collected from subjective complaint questionnaires, workplace observation and measurement of Vital Lung Capacity (VLC) of the batik workers.
Results: The results showed that 45.5% of the working tools used poor ergonomic designs. Batik in Malon Village used four chemical irritants: wax, alum, soda ash and lime. All of them could potentially lead to health problems. The result also showed that around 61% of batik workers complained about stinging/ burning eyes, 28% watery eyes and 11% red eyes. In addition, 22% of them complained about itchy skin, 6% redness in the skin and 6% pain in the skin. The VLC showed that 50% of respondents had normal VLC, 47% mild restriction and 3% severe restriction.
Conclusion: The area where the batik workers worked had high health and safety risks, but only 22% of respondents used Personal Protective Equipment (PPE) and all of the worn PPE did not meet the standards.
The effectiveness of the application of self-hypnosis and prenatal gentle yoga on emesis gravidarum in the first-trimester pregnant women
Authors: Anggasari Yasi , Fauziyatun Nisa  , Ratna Ariesta Dwi Andriani  , Yunik Windarti
Published: May 2024

Background: Emesis gravidarum is an inconvenience that often occurs in the first trimester of pregnancy. Continuous emission of gravidarum can be bad for the health of pregnant women and the fetus is conceived, so it must be overcome as early as possible, one of which can use non-pharmacological therapy, namely applying self-hypnosis and prenatal gentle yoga to reduce emissions of gravidarum can make pregnant women relax. This study aimed to analyze the application of self-hypnosis with Prenatal Gentle Yoga on emissions of gravidarum in first-trimester pregnant women.
Methods: The design of this study used a Quasi experimental design with a Two group pretest-posttest design without control using purposive sampling. This research was conducted on first-trimester pregnant women who experienced the emission of gravidarum in the PMB Nanik Sidoarjo of ​​32 pregnant women in the first trimester. The self-hypnosis was carried out every day for approximately 15-30 minutes for 1 week, while prenatal yoga was carried out 3 times a week for 30 minutes. Data collection on the intensity of nausea and vomiting used the Pregnancy Unique Quantification of Emesis and Nausea (PUQE)-24 scoring system questionnaire. Data analysis used an independent T-Test test.
Results: The results of the analysis of this study indicate that the mean difference in the Self Hypnosis treatment group is greater (1.77) than in the Prenatal Gentle Yoga group (1.25), which means that Self Hypnosis is more effective in reducing the intensity of nausea and vomiting in emesis gravidarum versus Prenatal Gentle Yoga.
Conclusion: Therapy Self Hypnosis and Prenatal Gentle Yoga can reduce the emission level of gravidarum in first-trimester pregnant women so that it can be used as an alternative therapy that is easy to apply and has minimal side effects by pregnant women who experience gravidarum emissions.
Analysis of the characteristics of pregnant women affect nurse interaction with self hypnosis approach in prevention of preeclampsia
Authors: Faridah Umamah  , Budi Santoso  , Esti Yunitasari  , Siti Nur Hasina  , Raden Khairiyatul Afiyah
Published: May 2024

Introduction: Preeclampsia is one of the most common medical problems during pregnancy and is the leading cause of maternal death worldwide. Through professional antenatal care services, increasing knowledge and behavior in pregnancy care is expected to be able to prevent the occurrence of preeclampsia. The interaction of the client nurse with the self-hypnosis approach will increase the mother's abilities. This study aimed to analyze pregnant women's characteristics influencing nurses' interaction with a self-hypnosis approach in the prevention of preeclampsia.
Methods: This is a cross-sectional study with 260 pregnant women who were taken using purposive sampling as the sample. The data analysis uses using chi-square test, and the result is considered significant if p < 0.05.
Results: At the induction stage, there were significant results on the characteristics of pregnant women with hypertension (p = 0.036) and the characteristics of pregnant women based on education (p = 0.019). At the suggestion stage, significant results were obtained on the characteristics of pregnant women with a hereditary history of preeclampsia (p = 0.023) and maternal characteristics based on knowledge (p<0.001). At the termination stage, significant results were obtained on the characteristics of the mother with a hereditary history of preeclampsia (p = 0.037) and the characteristics of the mother based on knowledge (p<0.001).
Conclusions: The mother's characteristics that affect the nurse's interaction with the self-hypnosis approach are hypertension history, hereditary history of hypertension, and the mother's knowledge about the prevention of preeclampsia.
The role of Platelet Rich Fibrin (PRF) membrane and conjunctival autograft on TGF-β and collagen type 1 expression in conjunctival wound healing: a literature review
Authors: Karisma I Nyoman Ananta , Sasono Wimbo , Fatmariyanti Susy
Published: May 2024

Link of Video Abstract: https://youtu.be/8w4jBvx0pJc
 
Background: Plasma-rich fibrine (PRF) membrane is a new biomembrane useful in ocular surface reconstruction technique. Since its development, PRF membrane has been used successfully in many studies; however, some controversies maintained. This literature study aims to evaluate the role of Platelet Rich Fibrin (PRF) membrane and conjunctival autograft on TGF-β and collagen type 1 expression in conjunctival wound healing.
Methods: This literature review compiles and elaborates on previous studies from many authors to support future experimental studies, which will be conducted to compare the effect of PRF membrane and conjunctival autograft on TGF-β and type 1 collagen expression.
Results: PRF has many advantages, such as the ability to reduce inflammation, rich in growth factors, and can be a temporary scaffold for fibroblast migration. However, despite its advantages, PRF is not widely used, unlike its counterpart techniques, such as conjunctival autograft. Conjunctival autograft has long been used as an option for ocular surface reconstruction techniques, but it has some limitations. The conjunctival autograft technique cannot be performed in large or bilateral conjunctival damage. Thus, the PRF membrane technique can become a perfect solution for such a case. This literature review will provide more information on how PRF can regulate inflammation and support the conjunctival wound healing process.
Conclusion: Some impacts of PRF membrane and conjunctival autograft are still unclear, especially their effect on TGF-β and type 1 collagen expression. This literature review is expected to encourage and support future experimental studies about the impact of PRF and conjunctival autograft on TGF-β and type 1 collagen expression.
Estimating the safe duration and concentration of benzene exposure in the workplace in the printing industry
Authors: Moch. Sahri  , Octavianus Hutapea  , Muslikha Nourma Romadhoni  , Friska Ayu  , Efi Sriwahyuni  , Shamsul Bahari Shamsudin
Published: May 2024

Introduction: Increased levels of benzene in the air in the work environment can increase the case of leukemia cancer in workers. In their every activity, printing workers unwittingly breathe benzene vapor from the solvent used in ink. This study aimed to estimate safe concentrations and exposure times when working with benzene exposure in the workplace.
Methods: The type of this study is observational and cross-sectional. The research sample consisted of 25 people who worked in the printing industry.
Results: Benzene measurements in the work environment in the production section range from 1.57-4.88 mg / m3 with an average level of 2.54 mg/m3. The average intake was 0.0243 mg/ kg/day, while the average Risk Quotient (RQ) value was >1 (88%), which means there is a risk of adverse effects due to exposure to benzene vapor. Based on the calculation results, the current conditions with the concentration and characteristics of workers obtained an average safe duration of 3.2 years. For safe concentration, assuming a working life of 25 years and with the characteristics of the workers, the average safe concentration value is 0.2 mg/m3.
Conclusions: The level of risk of benzene exposure will continue to increase as the working period increases. It can be prevented by taking technical and administrative control measures and using personal protective equipment.
Development of non-pharmacological pain management (behavioral intervention) model based on family-centered empowerment in toddlers with invasive procedures
Authors: Wesiana Heris Santy  , I Dewa Gede Ugrasena  , Yuni Sufyanti Arief  , Nur Hidayah  , Firdaus  , Resti Utami
Published: May 2024

Introduction: Communication between parents and health professionals in children about assessing and managing their children's pain with both oral and written instructions still needs to be improved. Children with a relationship with a parent or caregiver may be easier to assess and benefit from non-pharmacological treatment. This study aimed to evaluate the development of non-pharmacological pain management (behavioral intervention) model based on family-centered empowerment in toddlers with invasive procedures.
Methods: This study design is an explanation survey with cross sectional approach. The sample consisted of 115 mothers with toddler-age children subjected to invasive prosedures in Rumah Sakit Islam Surabaya using purposive sampling. The data was analyzed using SmartPLS.
Results: Non-pharmacological pain management model based on family-centered empowerment was formed from the mother factor, nurse factor, filial values, and appraisal. The greatest effect was on the filial values factor, with the T statistic value = 2.777.
Conclusions: Nonpharmacological pain management (behavioral intervention) is formed by the mother factor, nurse factor, filial values, and appraisal, where filial values are the most influential. Therefore, in conducting pain nursing care in the nurse's room, paying attention to the four factors above is necessary to improve the quality of care services, especially in comfort for toddler children who undergo invasive actions.
The effect of lavender aromatherapy on the incidence of dyspareunia in post partum mothers
Authors: Yunik Windarti  , Fitria Dwi Anggraini  , Hinda Novianti
Published: May 2024

Introduction: Sexual needs are very important for domestic harmony. The incidence of pain during sexual intercourse often occurs in postpartum mothers, which causes concern and fear of mothers doing these activities. One of the efforts to reduce the pain is lavender aromatherapy. This study aimed to analyze the effect of lavender aromatherapy on the incidence of dyspareunia in postpartum mothers.
Methods: The research design, which takes the form of a nonequivalent control group design, is quasi-experimental. Aromatherapy with lavender is the independent variable, and dyspareunia is the dependent variable. In Wonokromo Village, Surabaya, 102 respondents with accidental sampling for 3 months made up the population of postpartum mothers in 2022. The survey served as the research tool. The Spearman's test was used to assess the data.
Results: The majority of mothers who did not use lavender aromatherapy (55.9%) experienced severe dyspareunia, almost half of the mothers who used lavender aromatherapy (41.2%) experienced moderate dyspareunia, and mothers who always used lavender aromatherapy almost half (44.1%) had mild dyspareunia. There is a significant effect of lavender aromatherapy on the incidence of dyspareunia in postpartum mothers (p = 0.001).
Conclusions: The more mothers do not use lavender aromatherapy before having sex, the more severe the incidence of dyspareunia or pain during sexual intercourse.