bluuebunny/crossref_metadata_2025 huggingface dataset:
KARAKTERISTIK VEGETASI, HARA NITROGEN DAN KARBON ORGANIK TANAH PADA TEGAKAN HUTAN TAMAN NASIONAL GUNUNG-MERBABU DAN TEGALAN (The Characteristics of Vegetation, Soil Nutrients of Nitrogen and Soil Organik Carbon at Forest Stands of Mount-Merbabu National Park and Dry Field)
Authors:   Program Studi Ilmu Tanah, Fakultas Pertanian, Universitas Sebelas Maret Surakarta, Suyana Jaka , Krismonanto Wisnu , Muliawati Endang , Widijanto Hery , Hartati Sri ,   Mahasiswa Program Studi Ilmu Tanah, Fakultas Pertanian, Universitas Sebelas Maret Surakarta,   Program Studi Agroteknologi, Fakultas Pertanian, Universitas Sebelas Maret Surakarta
Published: December 2022

Java island, which has a wet tropical climate, has a variety of vegetation stands. This study examines the characteristics of vegetation, nutrient levels of N, and soil organic carbon (SOC) under forest stands of Mount-Merbabu National Park (Pine/ Pinus merkusii, Puspa/ Schima noronhae theaceae, Acacia/ Acacia decurren fabaceae, Bintamin/Cupressus sp, and Mixed) and dry field at a soil depth of 0-30 cm (0-10, 10-20, 20-30cm). Observations the characteristics of vegetation were made by Observing Plot Units measuring 50 m x 50 m with 3 replications, while the observations of N nutrients and SOC included: total-N, Organic-C, and bulk density soil with 3 replications as well. The research data were analyzed descriptively, followed by the F-Test and DMRT Test at 5% level. The results showed that the forest stands of Mount-Merbabu National Park has the highest species density value in Puspa forest stand, followed by Mixed, Pine, Acacia, and Bintamin. Soil tota-N and Organic-C content decreased with the increasing soil depth. The highest soil total-N content in the depth of 0-10 cm was in the Puspa forest stand (1.34%), while Acacia is 0.74%, and dry field is 0.34%. The highest of soil organic-C content was in the Puspa forest stand (9.53%), the lowest was Pine (2.85%) and dry field (2.12%). Puspa (Schima noronhae theaceae) can be recommended as a good type of reforestation plant.
Improving Patient Experience at Outpatient Clinics Using Continuous Improvement Tools
Authors: Siddiqui Muhammad Usman Hassan , Khafagy Abdullah A.
Published: December 2022

Patients satisfaction with fast and high-quality services is the most important in the healthcare settings and specially in outpatient departments and private clinics. High quality services on health sector are indicated by continuous quality improvement (CQI). CQI is a progressive incremental process focused on safety of all participants, outcomes, systematic process, regulated and improved working environment at the later than earlier stages. Among the various suggested strategies, we adopted the patents feedback to improve the quality of services our clinic. All of the patient visited hospital were sent a massage on mobile and requested to provide their feedback on our services. Roughly around 5% of all visitors responded and filled up questionnaire. Majority of them were satisfied with the services in various department. However, they provided us some suggestions to identify the further gaps and improve the services in improving patients experience at our clinic. We considered their feedback, identified problems, redesigned the policies and implemented. After implementation of new strategies, we preliminary again evaluated the patients’ feedback on our services. Patients feedback explores that optimized methods of services for the has considerably increased the patients’ satisfaction. Taken together, our this shows that patients’ feedback is very important factor to improve patients’ experience at outpatient clinics using continuous quality improvement tools. For that reason, this study would serve as reference for public health stack holders, administrators and researchers.
To the accuracy estimation of the high intensive flows of experimental data
Authors: Orlov Yurii Nikolaevich , Soloviev Viktor Olegovich
Published: December 2022

The computational aspects of processing a large volume of experimental data related to the unsteadiness of the process, measurement inaccuracy, and inaccuracy of classifying algorithms are investigated. The limitations of the Bayesian approach to the problem of pattern recognition are also considered, when the maximum probability of matching the current state to one of the basic standards is determined by decomposing the fragment under study according to a known basis.
Mean field approximation and the problem of multiple realizations in the BBGKY hierarchy on the example of a ferromagnet
Authors: Ivanov Anton Valerievich , Khilkov Sergey Andreevich
Published: December 2022

The paper considers a model of a ferromagnet constructed on the basis of the mean field approximation. This model is fully described Curie-Weiss theory within a single implementation (sample). The concept of the problem of the set of realizations (PMR) is introduced, which arises when the BBGKY hierarhy is closed — an implicit transition from the description ensemble of non interaction samples to the description of one sample. It is shown that the closure of the BBGKY hierarhy through the mean field approximation leads to TMR. At the same time, the approximation of correlation magnetodynamics makes it possible to avoid PMR and leads to a correct description of the entire ensemble at the level of one-two-particle distribution functions.
Hybrid approach to design of the composition of automotive paint to match the desired color based on neural networks and lighting simulation
Authors: Pozdnyakov Sergey Georgievich , Ershov Sergey Valentinovich , Voloboy Alexey Gennadievich
Published: December 2022

Modern automotive paints have a complex structure, and modeling their optical properties is a challenge. The inverse problem - the design of the paint composition according to its appearance - is most in demand in practical application. The shortcomings of popular mathematical methods, including previously used by the authors, are analyzed in the paper. A hybrid approach based on deep learning of a neural network and modeling of light propagation in a multilayer paint is proposed. The neural network algorithm solves the problem well for the pigments and paints on which it is trained, but is unstable for new pigments. In this case paint simulation helps to find an acceptable result. The mathematical model here provides only the functional form of the equations in variations, and the values of all functions are obtained by a few measurements which form a pigment library for future use.
Amortiguadores regenerativos para sistemas de suspensión automotriz: Una revisión
Authors: Barredo-Hernández Eduardo , Mendoza-Larios José Gabriel , Maldonado-Bravo Irving Abdiel , Mayén-Chaires Jan , Mazón-Valadez Cuauhtémoc
Published: December 2022

En este trabajo se presenta una revisión exhaustiva de los diferentes tipos de amortiguadores regenerativos utilizados para mejorar la reducción del consumo de combustible y de las emisiones contaminantes (principalmente el CO2) en vehículos comerciales. En primera instancia, se describe la interacción entre el tren motriz y el sistema de suspensión automotriz, incluyendo los ciclos de velocidad de conducción como el enlace principal. Posteriormente, se presenta un esquema gráfico del proceso de regeneración de energía vibratoria mediante amortiguadores regenerativos, considerando el sistema de almacenamiento de energía. Además, se discuten los avances tecnológicos recientes de los diferentes tipos de amortiguadores regenerativos, sopesando principalmente la filosofía de diseño del mecanismo de rectificación de energía vibratoria. Finalmente, se presentan las conclusiones y tendencias futuras sobre las aplicaciones de estos dispositivos en diferentes disciplinas de la ingeniería.
Gender Differences in Suicide Ideation
Authors: Lee Jung-Whan
Published: December 2022

Objectives: The purpose of this study is to examine suicide ideation among adults in Korea and to identify variables affecting the ideation. Methods: Data for the study were taken from the 2018 Korean General Social Survey which collected them from a national sample of 1,031 adults aged 18 and up who lived in households in Korea using face-to-face interviews with a structured questionnaire. The data were analyzed with descriptive statistics, bivariate analysis and logistic regression analysis. Results: The rate of suicide ideation is 12.7%. Although the rates of the suicide ideation are not significantly different between males and females, the variables affecting the suicide ideation are very different for males and females. Among the variables, health condition is the most important predictor of suicide ideation. Conclusions: Policies and programs for the prevention of suicide need to develop with consideration the different characteristics between males and females in suicide ideation.
Comparison of Food Service Provision by Food Service Operational Types for Residential Facilities
Authors: Kwon Jin Hee , Hwang Rah Il , Jeong Hyeon Jin , Jang Hye Min
Published: December 2022

Objectives: The purpose of this study aimed to compare the status of food service provision by residential facilities’s food service operational type. Methods: Data were collected by fax or web-based surveying nutritionists or facility managers working in 731 residential facilities in Korea. Residential facilities were extracted through a proportionate stratified sampling method based on region, establishment entity, types of food service, and facility size. Data analysis was performed using SAS program. Results: Among long term care facilities, self-operational food service types were 74.6% and outsourced service types 25.6%. It was found that outsourced service types were mostly chosen by private and independent establishments facilities. In addition, it was found that there were differences in food service personnel (full-time cooks, part-time cooks, and food service quality management managers), physical environments (senior living dining and cooking place), meal-related expenses, and providing food and nutrients(planing menu, compliance of menu plan, diabetic diet provision, served within 2 hours, identifying resident opinions) for each food service operation method. Finally, It was found that there were no differences in nutritional management (evaluation of nutritional status, nutrition intervention, food and nutrition service, nutrition education, nutrition counseling, multidisciplinary nutrition management by food service operational type. Conclusions: It is suggested that regulatory reforms are needed to establish a continuous monitoring and evaluation system for the quality of food service and nutrition management services for each food service type. In addition, it is suggested that a study to analyze whether there are differences in meal satisfaction, nutritional status, functional status and health status of subjects food service operational type.
A Study on the Availability of Survival Analysis of Lung Cancer Patients Using Synthetic Data
Authors: Yu Je-Hyeong , Lee Seunghee , Kim Jong-Yeup , Son Ji-Woong , Ku Gwan-Woo , Lee Suehyun
Published: December 2022

Objectives: This was a pilot study to investigate the possibility of clinical analysis to support the lack of sample size of real data and to generate synthetic data. Since real data has many limitations, such as ethical issues and costly issues, there have been many attempts to create realistic synthetic data. The focus is on whether synthetic data can be used instead of real data. Methods: This study analyzed 11,978 lung cancer patients who used anticancer drug therapy using synthetic data as a quasi-experimental study. Clinically significant variables were extracted and some tables containing patient status and treatment records were preprocessed. This experiment was applied to the propensity score matching technique to prevent the bias of covariates. Then, the preprocessed data were analyzed using Kaplan-Meier estimation and Cox proportional hazards model. Results: When plotting the survival curves, the curves from the synthetic data did not match the curves for the actual data of the other covariates. In Cohort 1, Gen I had a better 5-year OS than Gen II (S1=0.973, S2=0.953, p<0.05). Similarly, Gen I anti-cancer was better than Gen III in Cohort 2 (S1=0.990, S3=0.884, p< 0.05). In the exploratory sub-group analysis using the Cox regression model, the risk ratio was estimated. We found that Gen I had a better effect on hazard ratio than Gen II and III. However, those results were different from the actual trend. Conclusions: It was found that the analysis based on the DATA-FREE-BOX data was different from the trend of the survival analysis conducted with the real data. The trend of this analysis could be different from the real trend. It will be able to contribute to data-validation. Moreover, it is expected that the same methodology can be applied in clinical studies based on actual data by utilizing the technique used in this study.
Effects of the Violence Experience and Emotional Labor on Burnout among Tertiary Hospital Nurses
Authors: Kim Su Hyang , Noh Yoon Goo
Published: December 2022

Objectives: The purpose of this study is to identify the effect of violence experience and emotional labor on burnout among tertiary hospital nurses. This study is a correlation study that tests the relationship between variables. Methods: Subjects were 127 nurses working at a Pusan National University Yangsan Hospital, Gyeong-Nam Province and data were collected from August 27 to 31, 2018. The questionnaire included violence experience, emotional labor, and burnout. Data were analyzed by descriptive statistics, t-test, one-way ANOVA, Pearson’s correlation, multiple regression analysis using SPSS Win 21.0. Results: The mean score of verbal violence was 2.21±0.67, that of physical threat was 1.49±0.51, that of physical violence was 1.21±0.21, that of emotional labor was 3.62±0.67, and that of burnout was 3.21±0.60. Burnout has the positive relationship with the emotional labor (r=0.59, p<0.001), verbal violence(r=0.50, p<0.001), physical threat (r=0.44, p< 0.001); emotional labor has the positive relationship with verbal violence (r=0.40, p< 0.001) and physical threat(r=0.44, p< 0.001). Factors affecting burnout included emotional labor (β=0.44, p< 0.001), verbal violence (β=0.26, p=0.001), and unmarried (β=0.22, p=0.001), with 47.2% explanatory power (F=38.17, p<0.001). Conclusions: This study shows that emotional labor and experience of verbal violence are factors that exacerbate burnout in nurses. Therefore, a strategy is needed to reduce emotional labor and exposure to verbal violence.
Factors Related to Changes of Daily Life during COVID-19
Authors: Min Kyungjin , Yun Pilhan , Park Sangshin
Published: December 2022

Objectives: This study analyzed and identified factors related to the changes of the daily life, such as the health behavior, the number of meetings, and the use of public transportation during the COVID-19. Methods: A total of 133,707 people out of 229,269 adults aged 19 years or older in Community Health Survey 2020 were analyzed in terms of the daily life changes, including the demographic characteristics, health status, health behavior, mental health, and chronic disease. The multi-variable linear regression analysis was conducted with the considerable variables extracted from the stepwise selection. Results: It was found that age, sex, household type, job, household income, education level, subjective health status, breakfast, stress level, depression, hypertension, and diabetes are related to the changes of the daily life during the COVID-19. In particular, the age of 30s and 40s, women, second generation, white-collar worker, high income, well educated, worse subjective health status, skipping breakfast, high stress and depression factors were closely related to the negative changes of daily life during the COVID-19. Conclusions: The negative changes of daily life during the COVID-19 were more likely to occur in the group of the age of 30s and 40s, women, with high socioeconomic status, with worse health status, with worse health behaviors and with worse mental health.
An Analysis of Factors Influencing the Perception of Stress among Residents in Gyeongsangnam-do in COVID-19
Authors: Park Jong Ho , Lee Hee-Weon , Kim Ji Hye
Published: December 2022

Objectives: The purpose of this study is to identify the factors affecting the stress perception of residents in Gyeongsangnam-do in COVID-19 using the original data of the Community Health Survey by the Korea Centers for Disease Control and Prevention, and to suggest effective stress perception management strategies based on this. Methods: Data of 229,270 original data from the Community Health Survey of the Korea Centers for Disease Control and Prevention in 2020 during the COVID-19 epidemic period were collected. Frequency analysis and cross-analysis were conducted using SPSS Statistics 27 to identify the factors affecting the stress perception of residents in Gyeongsangnam-do in COVID-19, and a step-by-step selection method of logistic regression analysis was conducted to establish a stress perception management strategy. Results: As a result of this study, women in gender 1.80 (95% confidence interval, CI=1.21-2.67), age 19-44 years 7.68 (95% CI=2.36-25.00) and 45-64 years old (95% CI=1.46-4.21) and occupational administrative 4.50 (95% CI=1.89-10.70), Less than 1 million won in monthly household income is 4.66 (95% CI=1.95-11.15) and 100-3 million won is 2.31 (95% CI=1.00-5.31), residence, Jinhae-si 1.42 (95% CI=0.44-4.62), Sacheon-si 1.73 (95% CI=0.61-4.89), Gimhae-si 2.04 (95% CI=0.68-6.11), Masan-si 1.36 (95% CI=0.41-4.54), Jinju-si 2.26 (95% CI=0.77-6.65), Changwon-si 1.19 (95% CI=0.40-3.52), Currently, smoking oil was 2.02 (95% CI=1.17-3.47) in the presence or absence of smoking. Conclusions: Based on these results, in order to manage short-term stress awareness in Gyeongsangnam-do during the COVID-19 era, it is necessary to strategically implement stress management projects for women with monthly household income of less than 1 million won and 100-3 million won among residents in Jinhae, Sacheon, Gimhae, and Changwon.
Development and Effects of Pre-clinical Research Nurse Programs of Nursing Students
Authors: Kim Eun Hee
Published: December 2022

Objectives: Clinical research nurses play an important role in clinical trials. The purpose of this study was to identify the effect of pre-clinical research nurse program on biomedical ethics awareness, critical thinking disposition and teamwork in nursing students. Methods: This study was a non-equivalent control group pretest-posttest quasi-experimental design: the participants included 55 nursing students (28 in the experimental and 27 in the control group). Biomedical ethics awareness, critical thinking disposition and teamwork between the experimental and control groups were measured before and after the program participation. Data were collected from November 1 to 19, 2021 by taking a self reported survey and analyzed by using Chi-square test, Fisher’s exact test, Independent t-test, and Paired t-test with SPSS WIN 25.0 program. Results: The experimental group showed higher biomedical ethics awareness (t=2.15, p=0.036) relative to those of the conrol group after the program participation. However, there were no statistical differences in critical thinking disposition (t=1.29, p=0.204) and teamwork (t=1.97, p=0.054) between the twp groups. Conclusions: According to these results, pre-clinacal research nurse program developed in this study could be used to increase biomedical ethics awareness of nursing students. In addition, there is a need to develop modified programs with various teaching methods to increase the level of critical thinking disposition and teamwork as well as biomedical ethics awareness in nursing students who may become clinical research nurses in the future.
Association between Maternal Age and Complications of Pregnancy in Primipara
Authors: Ju Kyung-Sung , Kim Hye-Sook
Published: December 2022

Objectives: The purpose of this study was to analyze the association between maternal age and pregnancy outcome in primipara. Methods: We evaluated retrospectively the clinical characteristics and pregnancy outcomes in primiparous mothers who delivered a fetus after more than 22 weeks of gestation in I hospital from January 2017 to December 2018. Statistical analysis was performed using chi-square tests and multivariable logistic regression. The education, occupation, abortion history, assisted reproductive technology (ART) and multiple pregnancy all showed significantly higher incidence, depending on maternal age (p<0.000). Results: The odds ratio in maternal complications was 2.327 times higher in mothers 40 years and above than mothers 29 years and below, and 1.912 times higher in mothers 35-39 years than mothers 29 years and below. The odds ratio in gestational diabetes was 3.337 times higher in mothers 40 years and above than mothers 29 years and below, and 2.698 times higher in mothers 35-39 years than mothers 29 years and below. Conclusions: Consequently, this study showed a significant association between maternal age and pregnancy outcome in primipara. However, as the maternal age increases, the improvement of socioeconomic status and health level are expected to have a greater impact on outcome of pregnancy despite the physical defects of biological aging.
The Scrub Typhus Incidence Rate of Agricultural Workers in South Korea: Using Farmers’ Safety Insurance Data
Authors: Choi Dongphil , Kim Kyeongsu , Lee Minji
Published: December 2022

Objectives: We investigated the incidence rate of Scrub typhus in farmers. Methods: Data were obtained from 2016 to 2021 in the farmers’ safety insurance from NongHyup Life Insurance. The incidence was defined as a newly diagnosed patients with Scrub typhus in 2016-2020. The incidence rate was confirmed by sex, age and administrative districts. Results: The age-standardized incidence rate of Scrub typhus was 115 per 100,000 people from 2016 to 2020. The crude rate was presented to be 8.9, 43.8, 79.9, 127.2, 156.3, and 174.3 per 100,000 people, respectively, in the 40s to 80s or over. According to administrative districts, the highest crude rate was 201.6 and 193.0 per 100,000 people in Jeonnam and Gyeongnam, respectively, and the lowest crude rate was 6.0 per 100,000 people in Gangwon. And the monthly incidence was 54.3% in November and 32.0% in October, concentrated in autumn. Conclusions: The age-standardized incidence rate of Scrub typhus in Korea was 115.1 per 100,000 people, and it occurred more frequently in the southern regions in terms of administrative districts and increased with age. Based on this, it is thought that it will be helpful in establishing a management plan to prevent Scrub typhus.
Analyzing Survival Data with Competing Risks Based on R-packages
Authors: Kim Jinheum
Published: December 2022

When it comes to data in survival analysis, it is easy to think of one censored or observed survival time of an individual. In the longitudinal study such as a clinical trial, an individual may be simultaneously exposed to different types of events. It is easy to think of competing risks data as an extension of univariate survival data, but since competing risks events are dependent on each other, if the analysis method of univariate survival data is applied, inferences with bias can be made. In this paper, we briefly introduce the statistical methods developed to analyze competing risks data and apply them to the real examples using the built-in functions in the R package.
Concept Attainment Model (CAM) in Empowering Critical Thinking Skills and Concepts Mastery for High School Students
Authors: Asy'ari Asy'ari , Wikanta Wiwi , Juniawan Mulya Fitrah
Published: December 2022

Abstract.Existing human resources must be prepared early. Indeed, national education aims to create intelligent and competitive generations. This research is oriented towards the influence of CAM, which is implemented in the learning process. This research method is quasi-experimental. The research design used a non-equivalent control group design. As a sample is XI grade in SMA Muhammadiyah 7 Surabaya. Data collection techniques through observation and tests, critical thinking skills test sheets and students' concept mastery tests. Descriptively, self-critical thinking skills are 100% completed classically. The results of the t-test have a significance value of ≤ 0.05, which is 0.000. Then for mastery of the concept from the results of the t-test, the significance value is ≤ 0.05, namely with a significance value of 0.000. From the results of this study, it can be concluded that there is an influence of CAM p on students' critical thinking skills and students' mastery of concepts.
Your Information Literacy Practices (YILP): Information Literacy and Resourcefulness
Authors: Kennette Lynne N. , McIntosh Elizabeth
Published: December 2022

Post-secondary students bring with them unique skills and knowledge which may affect their learning. Information literacy (IL) is a set of abilities which permits the discovery of information as well as using this information to create new knowledge (Association of College and Research Libraries, 2016). While IL abilities are heralded as important, it is difficult to find a simple measure of information literacy, especially since its conceptualization as a framework (Association of College and Research Libraries, 2016). In this paper, we propose a new online measure of information literacy—Your Information Literacy Practices (YILP)—which aligns with the new framework. We compare it to another published measure of IL and student resourcefulness. Implications and recommendations for its use are discussed.
Synthesis of an Invariant Automatic Control Systems with an Internal Model
Authors: Kulakov G. T. , Kulakov A. T. , Voyush N. V.
Published: December 2022

The article is devoted to the modernization of typical cascade automatic control systems with stabilizing and corrective PI controllers. Such automatic control systems, in addition to the main signal (of adjustable value), use an additional leading signal that reacts to the disturbance faster than the main one. The leading signal effectively compensates for internal disturbances arising in the system by adjusting the stabilizing controller. The temperature control system of superheated steam boiler units of thermal power plants may be taken as an example. The task of determining the configuration parameters of such dual-circuit systems is quite difficult. With a relatively low inertia of the internal circuit, the speed of the stabilizing controller is quite high, and transients in it do not affect the quality of regulation in the external circuit with a corrective controller. This makes it possible to calculate the optimal settings of the latter only by the dynamic characteristics of the inertial section using conventional methods developed for single-circuit systems. The main disadvantage of such automatic control systems is that they do not allow, with close inertia of the contours, to significantly improve the quality of working out the main impacts during the jump of the task, internal and external disturbances. To eliminate this drawback, an invariant cascade automatic control system with an internal model is proposed that takes into account the dynamics of both the internal and external contours with an inertial section of the object when choosing the structure and setting up the corrective controller. In this case, the internal model is used to fully compensate for the main feedback of the system when working out the task signal, as well as to isolate an equivalent external disturbance, for which an invariance differentiator is used to compensate. The invariant cascade automatic control system makes it possible to significantly increase the speed and accuracy compared to the standard one.
Optimization of Composition of Nanofiber Concrete in Terms of Fracture Toughness by Matrix Modifiсation
Authors: Sadovskaya E. A. , Leonovich S. N.
Published: December 2022

Concrete is a quasi-brittle building material that has low tensile strength. The process of its destruction under loading is inhomogeneous, due to the nature of the concrete structure mass, consisting of components with different physical and mechanical properties. Gradual deformation and destruction can be characterized as a process of formation and development of microcracks. The presence of different-sized components in concrete makes it possible to consider its structure as a multi-level system. In this system, each level is a matrix with its own structural inclusions, which play both a structure-forming role and the role of stress concentrators under the action of mechanical loads. The critical stress intensity factor is a good indicator of the crack resistance (fracture toughness) of a material. Nanoconcrete, from the point of view of a multilevel system, is a concrete composite with crack propagation inhibitors at the level of the cementing substance (carbon nanotubes are consi-dered as inhibitors). The presence of fiber fibers at subsequent scale levels allows us to consider concrete as a composite with multi-level dispersed reinforcement (nanofiber concrete). The paper discusses the change of concrete fracture toughness indicator (crack resistance) with dispersed reinforcement of the matrix at different structural levels. The 

presented for normal separation of notched cubes under eccentric compression with the determination of the stress intensity factor for concrete modified with carbon nanotubes acting as crack propagation inhibitors at the level of cementing substance (nanoconcrete), as well as for nanofiber concrete with dispersed reinforcement at the level of fine-grained concrete. Based on experimental studies by non-equilibrium methods of fracture mechanics, compositions of nanofiber-reinforced concrete of maximum crack resistance (fracture toughness) with different fiber concentrations and several types of matrices modified with nanocarbon additives are proposed in the paper.
Assessment of the Role of Human Resources in Enhancing Competitiveness of Industrial Organizations in the Transition to Industry 4.0
Authors: Hu Minqjun , Ustsinovich I. V.
Published: December 2022

In the conditions of necessity of transition to Industry 4.0 the human resource potential is considered as an important source of competitive advantage.  Only qualified personnel can make an organization competitive on the basis of market loyalty, product and service quality, differentiated products and technological innovation. Two directions for increasing the competitiveness of industrial enterprises have been identified. The first is the assessment of the system of indicators of human resource level during the transition to Industry 4.0. The second is to identify the most significant factors in assessing the level of human resources that affect the increase in the level of competitiveness of industrial organizations. The paper provides a detailed analysis of a number of economic indicators that characterize the integral indicator of the effectiveness of the human resources development and competitiveness of an industrial organization. The integral indicator has formed the basis of a model for assessing the competitiveness of industrial organizations through human resource development. The model consists of two parts: human resource development and the increase in the level of competitiveness of industrial organizations. The model is based on the following factors: the quality of human resources (staff composition of an industrial organization, the number of employees, their income level, education level, projects related to human resource development) and its development (total corporate income, share employee remuneration in the total organization income, R&D costs, the share of investment in R&D in the total organization income, sales and production). The developed model will allow organizations to adjust their human resource development strategies (recruitment and further development of human resources), and will also contribute to the transformation of corporate talent.
Topological optimization of constructive solid geometry of lightweight structures
Authors: Kovaleva I. L. , Kunkevich D. P. , Naprasnikov V. V. , Polozkov Y. V. , Chvankov A. A.
Published: December 2022

The work is devoted to solving the problem of topological optimization in the design of lightweight structures. The advantages and disadvantages of popular topological optimization methods are analyzed. One of the characteristic problems of all methods is the dependence of their results on grid partitioning. Besides, there is a necessity to recast the geometry model of the structure. To solve this problem, it is proposed to perform the formation of cavities based on the ESO method directly at the constructive solid geometry from the shape elements. The main stages of the proposed approach are described, the use of clustering to simplify the shape of the surfaces of the formed cavities is justified.
Diferencia en el grado de desajuste del tornillo del pilar en la conexión pilar-implante entre dos implantes de conexión interna hexagonal de dos marcas distintas utilizando métodos de elementos finitos
Authors:   , Orrego Meneses Paolo Britaldo
Published: December 2022

Objetivo: El objetivo del presente estudio será determinar la diferencia en el grado de desajuste del tornillo del pilar en la conexión pilar-implante entre dos implantes dentales utilizando métodos de elementos finitos. Método: El siguiente estudio fue de tipo observacional, de correlación transversal. Se utilizó un implante Straumman y un implante Biohorizons. Se utilizó para modelar el programa Solid Works (CAD) y ANSYS (CAE) para la simulación de deformaciones. Resultados: La deformación se midió a 0,1 segundos cuando se aplicó la precarga de 400 N, y luego se midió a 0,3 segundos cuando se aplicó una fuerza máxima de 100 N sobre la supra estructura. Luego se midió a 0,5 segundos cuando se aplicó una fuerza máxima de 400 N sobre la supra estructura, y luego se midió a 0,7 segundos cuando se aplicó una fuerza máxima de 700 N sobre la supra estructura. Se midió el desajuste a nivel de la superficie interna del pilar respecto al interface pilar-implante. Discusiones: El Biohorizons sufre aprox. 10% más (374 MPa) durante la precarga. Respecto a la aplicación de la carga plena a 100 N sobre ambos implantes: Los pilares prácticamente no son afectados por la carga de 100 N (mordida). Podemos ver que quienes tienen ligera afectación es la zona de contacto con el pilar; si tenemos que elegir uno, el implante Straumman presenta una tensión de aproximadamente la mitad del Biohorizons. Conclusiones: Ambos diseños son completamente estables ante esta simulación.
Visualizing risky situations induces a stronger neural response in brain areas associated with mental imagery and emotions than visualizing non-risky situations
Authors: Zaleskiewicz Tomasz , Traczyk Jakub , Sobkow Agata , Kamil Fulawka , Alberto Megías-Robles
Published: December 2022

In an fMRI study, we tested the prediction that visualizing risky situations induces a stronger neural response in brain areas associated with mental imagery and emotions than visualizing non-risky and more positive situations. We assumed that processing mental images that allow for “trying-out” the future has greater adaptive importance for risky than non-risky situations, because the former can generate severe negative outcomes. We identified several brain regions that were activated when participants produced images of risky situations and these regions overlap with brain areas engaged in visual mental, speech, and movement imagery. We also found that producing images of risky situations, in contrast to non-risky situations, increased neural activation in the insula—a region involved in emotional processing. This finding is in line with previous results demonstrating that the insula is recruited by tasks involving induction of emotional recall/imagery. Finally, we observed an increased BOLD signal in the cingulate gyrus associated with reward-based decision making and monitoring of decision outcomes. In summary, risky situations increased neural activation in brain areas involved in mental imagery, emotional processing, and decision making. These findings imply that the evaluation of everyday risky situations may be driven by emotional responses that result from mental imagery.
Whole-brain in vivo base editing reverses autistic-like behaviors in mice
Authors: Li Weike , Chen Jinlong , Peng Wanling , Yuan Bo , Yuan Yiting , Xue Zhenyu , Wang Jincheng , Han Wenjian , Chen Zhifang , Shan Shifang , Xue Biqing , Zhang Shuqian , Zhang Chen , Zhu Shujia , Tai Yilin , Cheng Tian-Lin , Qiu Zilong
Published: December 2022

Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder with deficits in social communication and stereotypical behaviors. Whole-brain genome editing to correct single-base mutations and alleviate autistic-like behaviors in animal models has not been achieved. Here we developed an APOBEC-embedded cytosine base editor (AeCBE) system, for converting C·G to T·A base pairs. We demonstrate the effectiveness by targeting AeCBE to an ASD-associated mutation of the MEF2C gene (c.104T>C, p.L35P) in vivo. We constructed a Mef2c L35P heterozygous mouse, which exhibited autistic-like behavioral deficits. We programmed AeCBE to edit the mutated C·G base pairs of Mef2cin the mouse brain, via the intravenous injection of blood brain barrier (BBB)-crossing AAV. This treatment restored MEF2C protein levels and reversed impairments in social interactions and repetitive behaviors in Mef2c mutant mice. This work presents an in vivo base editing paradigm in which a single-base mutation in the brain could be successfully corrected.
One-Sentence Summary
Base editing in vivo in the mouse brain corrects autistic-like behaviors.
Abnormal patellar loading may lead to femoral trochlear dysplasia: an experimental study of patellar hypermobility and patellar dislocation in growing rats
Authors: Tang Shiyu , Li Weifeng , Wang Shengjie , Wang Fei
Published: December 2022

Background: This animal study aimed to explore the effects of patellar hypermobility and patellar dislocation on the developing femoral trochlea.
Methods: Seventy-two 3-week-old Wistar rats were randomly divided into three groups. The sham group (SG) underwent simple incision and suture of the skin and subcutaneous tissue; the patellar hypermobility group (PHG) underwent medial and lateral retinacular release; the patellar dislocation group (PDG) underwent plication of the medial patellofemoral retinaculum. Twelve rats in each group were euthanized at 3 and 6 weeks postoperatively, respectively, and specimens were collected. The bony sulcus angle (BSA), cartilaginous sulcus angle (CSA), trochlear sulcus depth (TSD), and thickness of the cartilage on the lateral facet (CTL), medial facet (CTM), and center (CTC) of the trochlea were measured on hematoxylin and eosin-stained sections.
Results: In the PHG and PDG, the femoral condyles became blunt, the trochlear groove became shallower, and cartilage became thicker compared with the SG. Compared with the SG, the PHG and PDG had significantly larger BSA and CSA values at 3 (p < 0.05) and 6 weeks (p < 0.005), and a significantly shallower TSD (p < 0.05). At 3 weeks, all cartilage thicknesses in the PHG and the CTC and CTM in the PDG were significantly thinner than in the SG (PHG vs SG: p = 0.009 for CTL, p < 0.001 for CTM, p = 0.003 for CTC; PDG vs SG: p = 0.028 for CTC, p = 0.048 for CTM). At 6 weeks, the CTC was thicker in the PHG and PDG than the SG (PHG vs SG: p = 0.044; PDG vs SG: p = 0.027), and the CTL was thinner in the PDG than the SG (p = 0.044).
Conclusion: Patellar hypermobility and patellar dislocation may result in trochlear dysplasia that worsens with age. Excessive or insufficient loading leads to trochlear dysplasia.
Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris
Authors: Agamia Naglaa Fathi , ElMulla Khalid Fawzi , Ghazala Rasha Ahmed , Alsayed Naglaa Mohamed , Abdelmaksoud Rania Elsayed , Elmonem Eman Abdel , Talat Eman Mahmoud , Zaki Inas Naser , Sabah Rana Mohamed , Melnik Bodo Clemens
Published: December 2022

The transcriptomic regulation induced by isotretinoin (13-cis retinoic acid) is still a matter of debate as short-term exposures of immortalized sebocytes with isotretinoin produced conflicting results. Based on translational evidence, it has been hypothesized that oral isotretinoin treatment upregulates the expression of the transcription factor p53. Twenty-five patients suffering from acne vulgaris were treated with isotretinoin (0.6 mg/kg body weight) for 6 weeks. Biopsies from back skin were taken before and after isotretinoin treatment for the determination of p53 expression by immunohistochemical staining, quantification of p53 protein concentration by enzyme-linked immunosorbent assay and TP53 gene expression by quantitative reverse transcription real time PCR. Fifteen socio-demographically cross-matched healthy volunteers served as controls. Isotretinoin treatment significantly increased the nuclear expression of p53 in sebaceous glands of treated patients compared to pre-treatment levels and p53 levels of untreated controls. Furthermore, the p53 protein and gene expression significantly increased in the skin after treatment. The magnitude of p53 expression showed an inverse correlation to acne severity score and body mass index. Under clinical conditions, isotretinoin induced the expression of p53, which controls multiple transcription factors involved in the pathogenesis of acne vulgaris including FoxO1, androgen receptor and critical genes involved in the induction of autophagy and apoptosis. Increased p53-FoxO1 signalling enhanced by systemic isotretinoin treatment explains the underlying transcriptomic changes causing sebum suppression but also the adverse effects associated with systemic isotretinoin therapy.
Advances in mechanistic study of control of oxidative stress injury through modulating HDAC6 activity
Authors: Xue Yuanye , Gan Bing , Zhou Yanxing , Wang Tingyu , Zhu Tong , Peng Xinsheng , Zhang Xiangning , Zhou Yanfang
Published: December 2022

Oxidative stress is defined as injury resulting from the disturbance on dynamic equilibrium of redox environment due to over-production of active/ radical oxygen exceeding the anti-oxidative ability in the body. It is a key step of genesis and development of various diseases. Oxidative stress is modulated by different factors and events, including modification of histone, the core of nucleosome. Modification of histone includes acetylation and deacetylation on certain amino acid residues; the process is catalyzed by different enzymes. Histone deacetylase 6 (HDAC6) is a unique deaetylating protease; it also catalyzes deacetylation of different non-histone substrates so as to regulate various physiologic processes. The intimate relationship between HDAC6 and oxidative stress has been demonstrated by different lines of study. The present paper aims at summarizing the data obtained from mechanistic study between HDAC6 and oxidative stress, in order to provide guidance for further investigations in term of mechanistic characterization and drug development.
Non-conventional colloidal aggregation in bacterial baths
Authors: Palacci Jérémie , Grober Daniel , Palaia Ivan , Ucar Mehmet Can , Hannezo Edouard , Šarić Anđela
Published: December 2022

In equilibrium, thermal forces agitate molecules that diffuse, collide, and bind to form materials. They are, however, insufficient to efficiently organize particles at the micron-scale due to slow dynamics and metastable states [1, 2]. Active agents present in a passive fluid generate forces and flows: a bath with active fluctuations[3, 4, 5, 6], whose use for synthetic assembly is primarily untapped. We investigate the aggregation of sticky colloids in an active bath of swimming E. Coli bacteria. We observe a slow but persistent rotation of the aggregates that originates in the chirality of the E.Coli flagella and directs aggregation into structures that are not accessible thermally. We elucidate the aggregation mechanism with a numerical model of spinning, sticky beads and reproduce quantitatively the experimental results. We show that internal activity controls the phase diagram and the structure of the aggregates. Taken together, our results highlight the promise of active baths for designing a new class of materials whose structural and mechanical properties are not accessible to thermal assembly.
Numerical Investigation of Water Inflow and Seepage Characteristics in a Tunnel crossing Two Overlapped Parallel Faults
Authors: Wu Jing , Wu Li , Han Yan-hua , Sun Miao , Lu Ya-ni
Published: December 2022

Water inflow is one of the main geohazards that threaten the safety of tunnels and other underground projects. Faulted zone is one of the important geological triggers for such events. Numerical investigations on the evolution of flow behavior in tunnels across fault zones are of significance to the predication and prevention of this type of geohazards. In this work, a numerical investigation model with two overlapped parallel faults is established according to the "Three Zones" fault structure theory. The rapid turbulent flow in the fault fractured zone and fault center core is simulated by using the improved Darcy-Brinkman (IDB) seepage model, while the slow laminar flow in ordinary rock zone is described by Darcy equation. The effect of relative position and distance between the tunnel surface and two overlapped parallel faults to the evolutions of pore pressure(P), flow velocity(V), and water inflow rate(Q) around the tunnel excavation surface is studied through several scenarios. Our Numerical investigation results reveals that while the tunnel face is excavated into the fault center core, the fractured zone, the ordinary rock zone, and the center of the overlapped faults, the pore pressure value ahead of the excavation face increases while the flow velocity decreases sequentially. The inflow rate is the largest while the tunnel face is excavated to center of the fault center core and is the lowest in the ordinary rock zone. Moreover, the inflow rate is closely related to the range of the overlapped area between the two parallel faults. The investigation results offer a helpful reference to predicting early warning of water inflow geohazard when a tunnel cross two overlapped parallel faults.