bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonality and spatial variability of dynamic precipitation controls on the
Tibetan Plateau
Authors: Curio Julia , Scherer Dieter
Published: September 2016

Abstract. The Tibetan Plateau (TP) is the origin of many large Asian rivers, which provide water resources for large regions in south and east Asia. Therefore, the water cycle on the TP and adjacent high mountain ranges, in particular the precipitation distribution and variability play an important role for the water availability for billions of people in the downstream regions of the TP. The High Asia Refined analysis (HAR) is used to analyse the dynamical factors that influence precipitation variability in the TP region, including the factors resulting in the enhancement and suppression of precipitation. Four dynamical fields that can influence precipitation are considered: the 300 hPa wind speed and wind speed 2 km above ground, the 300 hPa vertical wind speed, and the atmospheric water transport. The study focusses on the seasonality and the spatial variability of the precipitation controls and their dominant patterns. Results show that different factors have different effects on precipitation in different regions and seasons. This depends mainly on the dominant type of precipitation, i.e. convective or frontal/cyclonic precipitation. Additionally, the study reveals that the midlatitude westerlies have a high impact on the precipitation distribution on the TP and its surroundings year-round and not only in winter.
Real-time forecasting of typhoon inundation extent in a partially-gauged area through the integration of ARX-based models and a geographic information system
Authors: Ouyang Huei-Tau , Chen Yi-Chun
Published: September 2016

Abstract. This study presents a methodology for forecasting the extent of inundation and depth of distribution during typhoons in real-time. The proposed approach involves the construction of ARX and ARMAX models capable of predicting water-levels at the locations of on-site gauging stations and representative points located at the outlets of the sub-areas obtained by terrain analysis using a geographic information system. The models are constructed based on historical typhoon data and the results of numerical simulations related to inundation. A database comprising layers of inundation maps related to water-levels in each sub-area based on the assumption of flat-water and the digital elevation model (DEM) of the area were assembled prior to the typhoon. Water-levels during the typhoon are forecast using the constructed models, whereupon inundation sub-maps associated with the forecasted water-levels are extracted from the database. The resulting inundation map is comparable to that obtained using Synthetic Aperture Radar. Processing can be conducted in real-time and requires very little computational resources. This provides valuable lead time in which to conduct efforts aimed at damage mitigation during a typhoon.
How much cryosphere model complexity is just right? Exploration using the conceptual cryosphere hydrology framework
Authors: Mosier Thomas M. , Hill David F. , Sharp Kendra V.
Published: September 2016

Abstract. Making meaningful projections of the impacts that possible future climates would have on water resources in mountain regions requires understanding how cryosphere hydrology model performance changes under altered climate conditions and when the model is applied to ungaged catchments. Further, if we are to develop better models, we must understand which specific process representations limit model performance. This article presents a modeling tool, named the Conceptual Cryosphere Hydrology Framework (CCHF), that enables implementing and evaluating a wide range of cryosphere modeling hypotheses. The CCHF represents cryosphere hydrology systems using a set of coupled process modules that allows easily interchanging individual module representations and includes analysis tools to evaluate model outputs. CCHF version 1 (Mosier, 2016) implements model formulations that require only precipitation and temperature as climate inputs – for example variations on simple degree-index (SDI) or enhanced temperature index (ETI) formulations – because these model structures are often applied in data-sparse mountain regions, and perform relatively well over short periods, but their calibration is known to change based on climate and geography. Using CCHF, we implement seven existing and novel models, including one existing SDI model, two existing ETI models, and four novel models that utilize a combination of existing and novel module representations. The novel module representations include a heat transfer formulation with net longwave radiation and a snowpack internal energy formulation that uses an approximation of the cold content. We assess the models for the Gulkana and Wolverine glaciated watersheds in Alaska, which have markedly different climates and contain long-term US Geological Survey benchmark glaciers. Overall we find that the best performing models are those that are more physically consistent and representative, but no single model performs best for all of our model evaluation criteria.
A Facility Lighting Comparison Based on Energy Savings and Efficiency, Pollution Prevention and Life Cycle Assessment
Authors: Xu Zonghua , Mim Neelnayana Kalita , Franchetti Matthew , Kumar Ashok
Published: September 2016

The objective of this study is to compare the energy efficiency, potential energy savings and the environmental impact among different lighting types-incandescent lamps, CFL (compact fluorescent light) lamps and LED (light-emitting diode) lamps in a manufacturing facility. Three different tools were applied: Energy Assessment Spreadsheet (EAS), Pollution Prevention (P2) tool and GaBi 6. EAS was used to calculate the energy savings, P2 tool was used for carbon footprint analysis, and GaBi was used for the life cycle assessment (LCA) in lightings’ use phase. The results indicated a saving of over $21,000 and a reduction of 151 MT CO2e (metric tons of CO2 equivalents) greenhouse gases (GHGs) using CFL in comparison to incandescent lamps. Approximately, $24,000 could be saved and 170 MTCO2e of GHGs could be reduced by using LED lamps instead of incandescent lamps every year for the operation phase of the facility. The environmental impact categories identified from the LCA in lighting use phase indicated that using incandescent lamps for the facility was much more harmful for the environment than using CFL and LED lamps. Additionally, the environmental impact from the use of LED lamps for the facility was less than that of CFL lamps.
Applying Past Lessons Learned to the Relocation of Climate Change Induced Transboundary Displaced Persons
Authors: Nakayama Mikiyasu , Fujibayashi Hirotaka , Yoshioka Nagisa
Published: September 2016

This study aims to identify a useful and practical methodology to rehabilitate the livelihoods of climate change induced transboundary displaced persons (CCITDP) after they move to developed nations, in particular those from the Small Island Developing States in the Pacific Ocean. Migration sometimes causes conflicts among migrants, or between migrants and those in the host community. Such conflicts could be avoided or mitigated by examining the lessons learned from people’s past resettlement experiences—from those displaced by large infrastructure development projects in Asia and the Pacific or from evacuees of Fukushima due to the nuclear power plant disaster—and using these experiences to better cope with the emergence of CCITDP. Evacuees of an island that is sinking due to sea-level rise may be regarded as either voluntary migrants or CCITDP depending on when they leave the island. Although, lower-class people, who are vulnerable to hardships, will need to leave their homes earlier than wealthier people. These two groups of migrants should be assisted equally to avoid conflicts between the two groups because they may live in the same place after relocation and also to discourage them from staying on the island until they are entitled to assistance as CCITDP. Not all migrants will miss family bonds after relocation, and some may actually enjoy their emancipation from old customs by moving to a new place. The best destination for the first generation of migrants may differ from the best destination for their children.
Leadership Style and Perceived Organisational Politics as Predictors of Organisational Commitment among Civil Servants in Osun State
Authors: Fashola A. K. , Akanni A. A. , Ajila C. O.
Published: September 2016

This study examined the predictive roles of leadership styles and perceived organisational politics on organisational commitment among Civil Servant in Osun State. Primary data for the study were collected from a total of 248 Civil Servants in Osun state using the stratified random sampling technique. Three standardized Psychological Scales were used in the study. These were the Supervisors Behaviour Descriptive Questionnaire (SBDQ), Perception of Organisational Politics Scale (POPS) and Organisational Commitment Questionnaire (OCQ). Data collected were subjected to inferential statistics such as Pearson Moment Correlation and Multiple Regression. Results showed a significant positive relationship between leadership style and organisational commitment among Civil Servants in Osun State (r (246)=0.31, p < 0.05}. It also revealed a significant relationship between perceived organisational politics and organisational commitment {r =(246) = 0.20, p > 0.05}. It further showed a joint significant relationship among leadership style, perceived organisational politics and organisational commitment { F (2,245) = 16.21, p < 0.05}.The stepwise multiple regression analysis revealed that 9.4% variation in organisational commitment is explained by the democratic leadership style, autocratic leadership style and perceived organisational politics {r= 0.324, r2 (adj) = 0.0094, F (3,244) = 9.514, P < 0.05}. The study concluded that both leadership style and perceived organisational politics predicted organisational commitment.
Comparison of Visual Function after Implantation of Inferior Sector-Shaped Intraocular Lenses: Low-add +1.5 D vs +3.0 D
Authors: Yoo Aeri , Kwag Joo Young , Song In Seok , Kim Myoung Joon , Jeong Hyerin , Kim Jae Yong , Tchah Hungwon
Published: September 2016

Purpose

To compare visual function after implantation of multifocal Lentis comfort LS-313 MF 15 (group 1) or Lentis M plus LS-313 MF 30 (group 2) intraocular lenses (IOLs).

Methods

Patients between 49 and 76 years of age who received monocular cataract surgery with multifocal IOL implantation were analyzed. Patients were evaluated preoperatively and for 5 months postoperatively for distance, intermediate, and near visual acuities, and static photopic and mesopic contrast sensitivity. A satisfaction questionnaire was administered 5 months after surgery.

Results

Group 1 comprised 21 eyes and group 2 contained 34 eyes. Both groups had a statistically significant improvement in uncorrected and corrected distance visual acuities postoperatively (p<0.01). Uncorrected visual near acuity at 40 cm was better in group 2 (1 month: p = 0.013; 5 months: p = 0.051). Uncorrected intermediate visual acuity at 70 cm was better in group 1 (1 month: p = 0.060; 5 months: p = 0.044). No significant differences in contrast sensitivity were observed between the groups. Glare and halo symptoms were better in group 1 (glare: p = 0.044; halo: p = 0.029).

Conclusions

Inferior sector-shaped, near-addition IOLs with lower add powers (+1.5 D) provide good vision over longer working distances and show fewer glare and halo symptoms.
Cataract Formation after YAG Laser Vitreolysis: Importance of Femtosecond Laser Anterior Capsulotomies in Perforated Posterior Capsules
Authors: Noristani Rozina , Schultz Tim , Dick H. Burkhard
Published: September 2016

Purpose

To report a patient who developed a white cataract after Nd:YAG laser vitreolysis with a posterior capsule defect.

Methods

Femtosecond laser-assisted capsulotomy was performed for optic capture fixation in a patient with a cataract due to a posterior capsule defect after Nd:YAG laser-vitreolysis.

Results

A 55-year-old, highly myopic woman presented with visual impairment 4 days after Nd:YAG laser vitreolysis due to preexisting floaters. The slit-lamp examination showed a mature white cataract; therefore, the intactness of the posterior capsule could not be judged. The patient underwent cataract surgery with femtosecond laser-assisted capsulotomy. Intraoperatively, a highly disrupted posterior capsule was observed. Intraocular lens (IOL) was implanted into the ciliary sulcus and the anterior circular and centered capsulotomy was used for posterior optic capture fixation. Then vitrectomy was performed. No intraoperative or postoperative complications occurred.

Conclusions

YAG laser vitreolysis presents a new and promising therapeutic approach for floaters. However, the complications are unknown. We describe the induction of cataract as a major complication. Furthermore, the femtosecond laser can ensure a circular and complete anterior capsulotomy, which is essential for optic capture fixation in these cases.
Choroidal Thickness and Visual Prognosis in Type 1 Lesion Due to Neovascular Age-Related Macular Degeneration
Authors: Hernández-Martínez Pablo , Dolz-Marco Rosa , Hervás-Marín David , Andreu-Fenoll Maria , Gallego-Pinazo Roberto , Arévalo José Fernando
Published: September 2016

Purpose

To evaluate the association between subfoveal choroidal thickness and the visual outcome in eyes with type 1 choroidal neovascularization (CNV) due to neovascular age-related macular degeneration (nAMD).

Methods

This was a retrospective, longitudinal, cross-sectional study including patients diagnosed with nAMD type 1 lesions managed with intravitreal injections of ranibizumab in a PRN strategy during 24 months. Retrospective chart review of patients with type 1 CNV recording the visual acuity, number of intravitreal injections, multimodal imaging data, and follow-up period was performed. Subfoveal choroidal thickness was measured using enhanced depth imaging scans obtained with spectral-domain optical coherence tomography.

Results

Twenty-five eyes of 21 patients were included. The mean baseline logMAR best-corrected visual acuity was 0.52 (+0.35) (median 0.5; range 0.1-1; interquartile range (IQR) 0.3-0.8) and improved to 0.39 (+0.39) (median 0.4; range 0.1-1; IQR 0.2-0.5) by the end of the follow-up (p = 0.038). Subfoveal choroidal thickness was 202.8 (+60.3) μm (median 218; range 81-285; IQR 146-258). Statistical mixed effects model demonstrated an association between rate of improvement of visual acuity with subfoveal choroidal thickness after 24 months (p<0.001) (95% confidence interval 0.0002-0.0001 logMAR month μm); higher thickness values were correlated with better visual acuity.

Conclusions

Thicker subfoveal choroid was associated with better visual outcomes in patients with type 1 CNV due to nAMD following a strict PRN regimen with intravitreal ranibizumab at 24 months of follow-up.
Spectral versus Time-Domain OCT in Detecting Preoperative Epiretinal Membranes that Accompany Macular Holes
Authors: Rao Prethy , Yonekawa Yoshihiro , Thomas Benjamin J. , Drenser Kimberly A.
Published: September 2016

Purpose

To compare the sensitivities of spectral-domain optical coherence tomography (SD-OCT) versus time-domain OCT (TD-OCT) in identifying epiretinal membranes (ERM) preoperatively in patients who underwent surgery for full-thickness macular holes (FTMH).

Methods

This is an interventional retrospective case series of 59 eyes diagnosed with FTMHs who underwent 25-G pars plana vitrectomy with internal limiting membrane peeling between 2009 and 2015. Preoperative OCTs were obtained by SD-OCT (Spectralis, Heidelberg, Germany) or TD-OCT (Stratus, Carl Zeiss Meditec, Dublin, CA, USA). Volume scans were reviewed for ERM accompanying the FTMH. This was compared to indocyanine green-negative staining and intraoperative findings of ERM as the gold standard.

Results

Baseline characteristics between the SD-OCT and TD-OCT groups were comparable. Mean duration of postoperative follow-up was 41.4 weeks (±49.0). Of 59 eyes, 33 (55.9%) exhibited an ERM intraoperatively. Four ERMs (SD-OCT group) compared to 12 (TD-OCT group) were not visualized on preoperative OCT (p = 0.003). Sensitivity and specificity of SD-OCT in ERM detection was 79% and 100% compared to 14% and 91% for TD-OCT. Visual acuity improved in both arms (0.5 and 0.3 logMAR units in SD-OCT and TD-OCT, respectively (p = 0.002, 0.0002).

Conclusions

We found that SD-OCT was superior to TD-OCT in identifying the presence of ERM preoperatively in patients who underwent macular hole surgery. Since ERMs may decrease the chance of successful pharmacologic vitreolysis, we recommend using SD-OCT over TD-OCT in the evaluation of patients with FTMH to more accurately identify ERMs and allow more comprehensive treatment decisions (pharmacologic versus surgical).
Intravitreal Dexamethasone in the Management of Acute Endophthalmitis: A Comparative Retrospective Study
Authors: Moisseiev Elad , Abbassi Sam , Park Susanna S.
Published: September 2016

Purpose

To compare the clinical outcome of eyes with acute bacterial endophthalmitis treated with intravitreal injection of antibiotics with or without intravitreal dexamethasone.

Methods

This was a retrospective chart review of 63 eyes diagnosed with acute bacterial endophthalmitis and treated with vitreous tap and intravitreal injection of antibiotics, 19 eyes (30.2%) with and 44 eyes (69.8%) without concurrent intravitreal dexamethasone.

Results

Visual acuity had significantly improved by 1 week and was maintained long-term (p<0.001). There were no differences in visual outcome or rates of ocular complications between the groups. None of the eyes treated with dexamethasone required repeated intravitreal antibiotic injection while 6 (13.6 %) of the other eyes required repeated intravitreal antibiotic injection (p = 0.09). A subset analysis of 21 eyes that presented with light perception/no light perception vision where vitrectomy was not possible demonstrated that intravitreal antibiotic injection improved vision and achieved similar visual gain as in eyes that presented with hand motion vision or better, with no higher complication rates.

Conclusions

No adverse effect of intravitreal dexamethasone in the acute management of infectious endophthalmitis was noted. A trend toward less need for repeat intravitreal antibiotic therapy was noted in eyes with acute bacterial endophthalmitis treated with concurrent intravitreal dexamethasone at presentation.
Partial LVAD Restores Ventricular Outputs and Normalizes LV but not RV Stress Distributions in the Acutely Failing Heart in Silico
Authors: Sack Kevin L. , Baillargeon Brian , Acevedo-Bolton Gabriel , Genet Martin , Rebelo Nuno , Kuhl Ellen , Klein Liviu , Weiselthaler Georg M. , Burkhoff Daniel , Franz Thomas , Guccione Julius M.
Published: September 2016

Purpose

Heart failure is a worldwide epidemic that is unlikely to change as the population ages and life expectancy increases. We sought to detail significant recent improvements to the Dassault Systèmes Living Heart Model (LHM) and use the LHM to compute left ventricular (LV) and right ventricular (RV) myofiber stress distributions under the following 4 conditions: ( 1 ) normal cardiac function; ( 2 ) acute left heart failure (ALHF); ( 3 ) ALHF treated using an LV assist device (LVAD) flow rate of 2 L/min; and ( 4 ) ALHF treated using an LVAD flow rate of 4.5 L/min.

Methods and Results

Incorporating improved systolic myocardial material properties in the LHM resulted in its ability to simulate the Frank-Starling law of the heart. We decreased myocardial contractility in the LV myocardium so that LV ejection fraction decreased from 56% to 28%. This caused mean LV end diastolic (ED) stress to increase to 508% of normal, mean LV end systolic (ES) stress to increase to 113% of normal, mean RV ED stress to decrease to 94% of normal and RV ES to increase to 570% of normal. When ALHF in the model was treated with an LVAD flow rate of 4.5 L/min, most stress results normalized. Mean LV ED stress became 85% of normal, mean LV ES stress became 109% of normal and mean RV ED stress became 95% of normal. However, mean RV ES stress improved less dramatically (to 342% of normal values).

Conclusions

These simulations strongly suggest that an LVAD is effective in normalizing LV stresses but not RV stresses that become elevated as a result of ALHF.
Statistical Optimization of Chitosan Nanoparticles as Protein Vehicles, Using Response Surface Methodology
Authors: Kiaie Nasim , Aghdam Rouhollah M. , Tafti Seyed H.A. , Emami Shahriar H.
Published: September 2016

Background

There has been increased attention given to polymeric nanoparticles as protein carriers. In this regard, chitosan/tripolyphosphate (TPP) nanoparticles are considered to be a simple and efficient carrier. However, to have an ideal protein release profile, we need to optimize the properties of the carrier.

Methods

This study examined the influence of 4 critical process parameters on the physicochemical characteristics of final nanoparticles. Chitosan-based nanoparticles were produced by ionic gelation, and then the size, polydispersity and zeta potential of those resulting nanoparticles were evaluated. Subsequently, the encapsulation efficiency of bovine serum albumin as model protein was investigated.

Results

The morphologies of nanoparticles were characterized using field emission scanning electron microscopy (FE-SEM). Linear mathematical models were presented for each response through 3 levels using Central Composite Design with the help of design of experiments software, and formulation optimization was performed.

Conclusions

Such research will serve as a basic study in protein loading into TPP cross-linked chitosan nanoparticles.
From Honeycomb- to Microsphere-Patterned Surfaces of Poly(Lactic Acid) and a Starch-Poly(Lactic Acid) Blend via the Breath Figure Method
Authors: Duarte Ana Rita C. , Maniglio Devid , Sousa Nuno , Mano João F. , Reis Rui L. , Migliaresi Claudio
Published: September 2016

Background

This study investigated the preparation of ordered patterned surfaces and/or microspheres from a natural-based polymer, using the breath figure and reverse breath figure methods.

Methods

Poly(D,L-lactic acid) and starch poly(lactic acid) solutions were precipitated in different conditions – namely, polymer concentration, vapor atmosphere temperature and substrate – to evaluate the effect of these conditions on the morphology of the precipitates obtained.

Results

The possibility of fine-tuning the properties of the final patterns simply by changing the vapor atmosphere was also demonstrated here using a range of compositions of the vapor phase. Porous films or discrete particles are formed when the differences in surface tension determine the ability of polymer solution to surround water droplets or methanol to surround polymer droplets, respectively. In vitro cytotoxicity was assessed applying a simple standard protocol to evaluate the possibility to use these materials in biomedical applications. Moreover, fluorescent microscopy images showed a good interaction of cells with the material, which were able to adhere on the patterned surfaces after 24 hours in culture.

Conclusions

The development of patterned surfaces using the breath figure method was tested in this work for the preparation of both poly(lactic acid) and a blend containing starch and poly(lactic acid). The potential of these films to be used in the biomedical area was confirmed by a preliminary cytotoxicity test and by morphological observation of cell adhesion.
Anisotropy in the Viscoelastic Response of Knee Meniscus Cartilage
Authors: Coluccino Luca , Peres Chiara , Gottardi Riccardo , Bianchini Paolo , Diaspro Alberto , Ceseracciu Luca
Published: September 2016

Background

The knee meniscus is instrumental to stability, shock absorption, load transmission and stress distribution within the knee joint. Such functions are mechanically demanding, and replacement constructs used in meniscus repair often fail because of a poor match with the surrounding tissue. This study focused on the native structure–mechanics relationships and on their anisotropic behavior in meniscus, to define the target biomechanical viscoelastic properties required by scaffolds upon loading.

Methods

To show regional orientation of the collagen fibers and their viscoelastic behavior, bovine lateral menisci were characterized by second harmonic generation microscopy and through time-dependent mechanical tests. Furthermore, their dynamic viscoelastic response was analyzed over a wide range of frequencies.

Results and conclusions

Multilevel characterization aims to expand the biomimetic approach from the structure itself, to include the mechanical characteristics that give the meniscus its peculiar properties, thus providing tools for the design of novel, effective scaffolds. An example of modeling of anisotropic open-cell porous material tailored to fulfill the measured requirements is presented, leading to a definition of additional parameters for a better understanding of the load transmission mechanism and for better scaffold functionality.
Evaluation of Calcium Dihydroxide- and Silver-Coated Implants in the Rat Tibia
Authors: Harrasser Norbert , de Wild Michael , Gorkotte Johannes , Obermeier Andreas , Feihl Susanne , Straub Melanie , von Eisenhart-Rothe Ruediger , Gollwitzer Hans , Rüegg Jasmine , Moser Walter , Gruner Philipp , Burgkart Rainer
Published: September 2016

Background

Silver ions (Ag+) have strong antibacterial effects, and silver-coated materials are in widespread clinical use. However, the application of silver-coated medical devices is not without concerns: its use with direct bone contact is not established, and systemic toxic side effects of released Ag+ have been described. Therefore, alternative bactericidal coatings with a more localized way of acting – e.g., calcium dihydroxide, Ca(OH)2 (CH) – would be advantageous.

Methods

A new rat model of the animal's tibial metaphysis was developed. In the left proximal tibiae of 36 male Wistar rats, titanium screws were implanted. The screws were coated with hydroxyapatite (HA; 12 animals: group I), low-dosed HA silver (HA-Ag; 12 animals: group II) and CH (12 animals: group III). After 6 weeks, all rats were sacrificed. The implants were evaluated for morphological changes on their surfaces, by light microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy; for osteointegration, by measurement of resistance to removal; and for bacterial colonization, by quantitative culture analysis. Additionally, the tibial bone was investigated histologically for signs of osteomyelitis and sonicated to detect bacterial loads.

Results

(i) No microbiological or histological signs of infection could be determined on any of the screws or the surrounding bone. (ii) The bone-implant interface analysis revealed extensive bone formation and direct bone-implant contact on all HA, HA-Ag and HA-CH coated screws. (iii) HA and HA-Ag were partially, and CH was fully, degraded on the screw coating, allowing host bone to osteointegrate.
The Role of MDM4 SNP34091 A>C Polymorphism in Cancer: A Meta-Analysis on 19,328 Patients and 51,058 Controls
Authors: Jin Xin , Zhao Wenchao , Zheng Minghua , Zhou Peng , Niu Tianli
Published: September 2016

Background

Cancer is one of the leading causes of death in the world. Several observational studies have suggested a significant association of the MDM4 SNP34091 A>C polymorphism with cancers. However, the results of the published studies are inconsistent.

Materials and methods

PubMed, Embase/Ovid and the Chinese National Knowledge Infrastructure were searched for relevant studies with a time limit of April 20, 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the association between MDM4 polymorphism and cancer risk. Publication bias was estimated using Begg's funnel plots and Egger's regression test.

Results

A total of 19,328 patients and 51,058 controls were included in the analysis. Overall, a significantly decreased risk of cancer was associated with MDM4 SNP34091 polymorphism for the allele model (C vs. A, OR = 0.715, 95% CI: 0.622-0.821, p = 0.000), dominant model (CC + AC vs. AA, OR = 0.684, 95% CI: 0.563-0.831, p = 0.000), recessive model (CC vs. AC + AA, OR = 1.139, 95% CI = 1.055-1.230, p = 0.001) and heterozygote model (AC vs. AA, OR = 0.687, 95% CI = 0.568-0.832). In the subgroup analysis by cancer type, no significant association was found in the breast cancer subgroup. In the subgroup analysis by geographical region, 2 genetic models, the allele and heterozygote models, showed a significant association in Chinese populations.

Conclusions

The results of our meta-analysis showed that the MDM4 SNP34091 A>C polymorphism may function as a protective factor against cancer risk.
Serum Mesothelin, Osteopontin and Vimentin: Useful Markers for Clinical Monitoring of Malignant Pleural Mesothelioma
Authors: Bonotti Alessandra , Simonini Silvia , Pantani Elena , Giusti Laura , Donadio Elena , Mazzoni Maria Rosa , Chella Antonio , Marconi Letizia , Ambrosino Nicolino , Lucchi Marco , Mussi Alfredo , Cristaudo Alfonso , Foddis Rudy
Published: September 2016

Introduction

Malignant pleural mesothelioma (MPM) is a relatively rare tumor, with the epithelioid type occurring more frequently. Several biomarkers have been suggested for screening and early diagnosis of MPM. Currently, high levels of soluble mesothelin-related peptides (SMRP), plasma osteopontin (pOPN) and vimentin have been reported in patients with MPM as promising markers for diagnosis, but their clinical use in monitoring is still discussed. The aim of our study was to evaluate the usefulness of these substances as markers of the clinical response to treatment in patients suffering from epithelioid mesothelioma.

Methods

219 serum samples from 56 patients were collected during follow-up and the clinical response to therapy was recorded. Percentage differences between 2 consecutive measurements of SMRP, osteopontin and vimentin (Δ markers) by means of commercially available kits were correlated with changes in the clinical course.

Results

Δ SMRP, Δ pOPN and Δ vimentin showed statistically significant differences between the disease categories stable disease, partial response and disease progression (p = 0.0001, p = 0.035 and p = 0.0025 for SMRP, pOPN and vimentin, respectively). Moreover, contingency table analysis showed statistically significant differences between clinical response and Δ of each marker clustered into 3 groups (<-20%, between -20% and +20%, >+20%).

Conclusions

The time course of Δ SMRP and Δ vimentin was strongly associated with disease status, and so was the time course of pOPN, albeit to a lesser extent. These markers appear to be particularly effective in cases of partial response and disease progression, while their possible use in stable disease should be better investigated.
Does Endometriosis Affect PAPP-A Concentration in First Trimester Fetal Screening Test?
Authors: Corigliano Maria Caterina , Martelli Federica , Capogna Maria Vittoria , Bruno Antonella , Sorge Roberto , Sarta Simona , Piccione Emilio , Pietropolli Adalgisa
Published: September 2016

Objective

Pregnancy-associated plasma protein A (PAPP-A) is a macromolecular glycoprotein. The peritoneal fluid of women affected by endometriosis shows a significant increase of PAPP-A levels. Given the important role of PAPP-A in first trimester screening test, we wondered if its presence in the peritoneal fluid of women with endometriosis could affect biochemical parameters of the test performed during pregnancy.

Methods

A prospective study enrolled 78 women with singleton pregnancy who performed combined test between 11 + 0 and 13 + 6 weeks of gestation: 25 women with previous histological diagnosis of endometriosis and 53 women without. All patients were sampled to determine PAPP-A concentrations. Serum levels of PAPP-A were expressed in UI/L and in MoM (multiples of median). The two groups – endometriosis women and non-endometriosis women – were compared in order to find a possible different concentration of serum PAPP-A.

Results

We found an increased concentration of both PAPP-A UI/L and PAPP-A MoM in deep endometriosis patients versus ovarian endometriosis with significant difference in PAPP-A MoM (p = 0.018). We also found a significant association between the stage of the disease and PAPP-A UI/L and MoM levels (PAPP-A UI/L p = 0.05, PAPP-A MoM p = 0.01).

Conclusions

Women with deep endometriosis show increased serum PAPP-A concentrations compared to women with ovarian endometriosis. Likewise, women with moderate or severe stage of the disease show increased serum PAPP-A concentrations compared to women with minimum or mild disease. This increase could affect first trimester aneuploidy screening test and endometriosis could represent a confounding factor in the calculation of aneuploidy risk.
Low-Angled Peripheral Intravenous Catheter Tip Placement Decreases Phlebitis
Authors: Tanabe Hidenori , Murayama Ryoko , Yabunaka Koichi , Oe Makoto , Takahashi Toshiaki , Komiyama Chieko , Sanada Hiromi
Published: September 2016

Introduction

Peripheral intravenous catheters (PIVCs) are frequently removed due to phlebitis. We hypothesized that catheters made of polyurethane, which is more flexible than Teflon, would decrease phlebitis, and that flexibility could be estimated by measuring the catheter-tip angle. Ultrasonography in two groups of patients with different catheter types was then used to compare catheter-tip angles and phlebitis.

Methods

Observational studies were carried out at a medical ward in a university hospital. Infusion therapy was administered to one group of patients in 2014 using Teflon catheters (control group, n = 200), and to another group of patients in 2015 using polyurethane catheters (investigational group, n = 207). The symptoms were assessed according to a scale developed by the Infusion Nurses Society. Long-axis ultrasonography images taken immediately before catheter removal were used to measure the angle between the central line of the catheter within 2 mm from the distal point and a tangent to the vessel wall.

Results

There were no significant differences between the two groups with respect to sex, age, and medical diagnosis. In the control and investigational groups, the rates of phlebitis were 37% (73/200) and 17% (36/207), respectively (p<0.001). The median angles of the catheter tip were 7.8° and 4.1°, respectively (p<0.001). Phlebitis occurred more frequently when the catheter-tip was placed at angle >5.8°.

Discussion

The frequency of phlebitis was lower in the polyurethane, in which the catheter was placed at lower angle, almost parallel to the vessel. Our results will aid in developing new catheters and in improving PIVC-securement techniques.
Trends in Gastric and Esophageal Cancer Incidence in Northern Portugal (1994-2009) by Subsite and Histology, and Predictions for 2015
Authors: Castro Clara , Peleteiro Bárbara , Bento Maria José , Lunet Nuno
Published: September 2016

Introduction

Gastric cancer (GC) and esophageal cancer (EC) share risk factors, and the incidence trends reflect differences in etiology according to their subtypes. We aimed to describe the incidence trends of GC (by topography) and EC (by histological type) in northern Portugal for 1994-2009 and to estimate the incidence for 2015. We further analyzed exposure to the main risk factors for these cancers in the region over the last decades.

Methods

GC and EC data were obtained from the North Region Cancer Registry of Portugal (RORENO). Joinpoint regression was used to compute annual percent changes (APC) in incidence trends. Poisson regression yielded estimates for 2015. A literature review up to 2014 provided data on exposure to risk factors.

Results

GC rates decreased in 1994-2009 (men, APC = −1.3; women, APC = −1.6); GC, unspecified subtype, had the steepest decline since the early 2000s (men, APC = −4.9; women, APC = −6.3). The incidence for 2015 will increase for EC in men (up to ≈190 cases) and stabilize in women (≈30) and for GC (≈730 men, ≈500 women). Increasing prevalence of tobacco smoking among women and overweight/obesity, fairly stable prevalence of alcohol, fruit and vegetable consumption, and no trend for Helicobacter pylori infection were observed.

Conclusions

The declining incidence of GC unspecified subtype indicated an improvement in cancer registration accuracy, but precluded a sound assessment of trends by subtype. Variations in the prevalence of exposure to some risk factors were consistent with observed incidence trends, and future studies should aim to quantify their contribution to the GC and EC burden in the region.
How the Lab is Changing Our View of Colorectal Cancer
Authors: Cremolini Chiara , Pietrantonio Filippo
Published: September 2016

In metastatic colorectal cancer, the optimization of upfront treatment and the continuum of care based on patients’ exposure to multiple treatment lines have reached a plateau of efficacy. Therefore, a paradigm shift is ongoing towards precision medicine and personalized treatments based on the specific molecular features of the disease. In this perspective, the improved knowledge of disease biology coming from the lab has prompted a rapid translation from bench to bedside of newer targeted strategies. Here, we focus on the most promising biomarkers already included or close to adoption in daily clinical practice. In particular, evidence about the potential roles of BRAF mutation, HER2 amplification, MGMT methylation, microsatellite instability, and ALK, ROS and NTRK1–3 rearrangements as positive predictors of benefit from biological agents is reviewed and discussed.
Posttransplant Solid Organ Malignancies in Lung Transplant Recipients: A Single-center Experience and Review of the Literature
Authors: Bennett David , Fossi Antonella , Refini Rosa Metella , Gentili Francesco , Luzzi Luca , Voltolini Luca , Paladini Piero , Mazzei Maria Antonietta , Rottoli Paola
Published: September 2016

Purpose

Solid-organ tumor incidences are higher in solid organ transplant patients than in the general population. The aim of this study was to analyze solid-organ tumor frequency and characteristics in a population of lung transplant patients and provide a brief review of the literature.

Methods

A retrospective analysis was conducted of all patients who underwent a lung transplant in the Lung Transplant Program at the University Hospital of Siena, Italy, from 2001 to 2014 (n = 119). Patients’ demographics, pretransplant characteristics, immunosuppressive therapy, and infectious factors were recorded.

Results

Nine patients with a median age of 59.0 years (range 50–63) of our cohort developed a solid-organ tumor (7.5%). Most of the patients experienced nonmelanoma skin cancer (44.4%); the others were diagnosed with lung cancer (22.2%), breast cancer (22.2%), and colon-rectal cancer (11.2%). The median time from transplantation to tumor diagnosis was 895.0 days (range 321–2046). No differences in pretransplant characteristics, immunosuppressive therapy, or infectious factors were found between patients who developed solid organ tumors and those who did not.

Conclusions

The present study confirmed that de novo malignancies are a major issue in lung transplant patients; in particular, skin and lung cancers demonstrated a higher incidence rate. Oncologic treatment of these patients is complex, requiring close collaboration between the transplant team and oncologist. Strict screening programs are key factors for an early diagnosis and to allow for prompt treatment resulting in a better outcome.
Seminal Plasma Calcium in Normal and Infertile Patients
Authors: Skandhan Kalanghot P. , Mazumdar Birendranath , Sumangala Balakrishnan , Jaya Vasudevan
Published: September 2016

Introduction

In this study an attempt is made to find out the level of calcium in seminal plasma of normal and infertile patients.

Materials and Methods

Semen samples are collected from 34 normal men and 112 infertile patients. After semen evaluation seminal plasma was separated and calcium level was measured in it.

Results

Calcium level in mg% is recorded in each group as follows; in normozospermia (n34) 20.14 ± 1.25 (±SE), oligozoospermia (n26) 9.76 ± 1.17, azoospermia (n33) 14.65 ± 2.63, oligoasthenozoosperma (n28) 20.91 ± 1.94 and in asthenozoospermia (n25) 11.56 ± 1.68. Statistically highly significant reduction in calcium is seen in Oligozoospermia and asthenozoospermia.

Conclusions

The probable reasons for these two conditions are discussed.
Level of Copper in Human Split Ejaculate
Authors: Skandhan Kalanghot , Valsa James , Sumangala Balakrishnan , Jaya Vasudevan
Published: September 2016

Purpose

The purpose of this study was to understand the details of splits of an ejaculate and to locate the origin of release of copper into semen.

Methods

Laboratory methods routinely followed for semen analysis were carried out. Copper was estimated by employing atomic absorption spectrophotometry.

Results

First split of ejaculate showed the highest number of motile sperm, the quality of which decreased from first to third. Copper level in splits 1, 2 and 3 was 29, 23 and 22 µg%, respectively.

Conclusions

This study concluded that copper was released from throughout the genital tract.
Exploring the Roles of Parents and Students in EFL Literacy Learning: A Colombian Case
Authors: Torres Sergio Aldemar Hurtado , Castaneda-Pena Harold Andres
Published: September 2016

There is little scholarly information about parent involvement in their children’s English as a Foreign Language (EFL henceforth) literacy learning in the Colombian context. This exploratory-qualitative study looks into the possible roles of parents and children in EFL literacy learning at home, with special emphasis on parental roles and contributions. The study has a three-fold purpose: (1) to describe the behaviour of parents and students when doing EFL literacy tasks at home, (2) to explore feelings and thoughts (perceptions) of parents and students about working together on EFL literacy tasks at home, and (3) to identify ways in which parents contribute to a student’s EFL learning. Sixteen ninth grade students at a state school, and their parents or caregivers, carried out a series of EFL literacy tasks in their respective homes. Video recordings, field notes, qualitative interviews, and surveys were used as data collection tools. The results demonstrate that even when parents do not have a command of the English language, they have the potential to help with EFL learning from a non-linguistic point of view (e.g. monitoring children's homework, providing learning conditions, shaping children’s minds for EFL by giving advice, and feedback about EFL homework development).
The Caring-Uncaring Emotional (CUE) Inventory: A Pilot Study of a New Measure of Affective Psychopathy Traits
Authors: Semel Robert A.
Published: September 2016

An affective dimension of psychopathy, e.g., callousness, lack of empathy, unemotional responsiveness, is essential to the study and understanding of psychopathy. It may be advantageous to have available brief measures of the affective dimension that may be utilized with adults and/or youths. The current study aims to provide preliminary validation of a new, brief, self-report measure of the affective dimension of psychopathy that may be suitable in the study of both adults and adolescents. A pilot study of the Caring-Uncaring Emotional (CUE) Inventory was conducted with 155 men and women recruited from a community sample. The 23-item CUE Inventory was found to have high internal consistency reliability (α = .91) and was found to have high correlations with an expanded, 36-item version of the Levenson Self-Report Psychopathy Scale (LSRP; Levenson, Kiehl, & Fitzpatrick, 1995), especially with the expanded LSRP Callous subscale (r = .85), thus supporting preliminary concurrent validity. The CUE was only modestly associated with the Antisocial subscale of the expanded LSRP, further supporting it as a measure of affective rather than behavioral traits. The CUE accounted for an additional 57% of the variance in LSRP total scores after controlling for demographic variables. An Exploratory Factor Analysis suggested a three-factor solution, with the first factor accounting for approximately 37% of the variance in scores and with high to very high loadings on this factor, which appears, tentatively, as a good measure of callousness. In conclusion, the CUE may function as an operational representative of callousness in adults in a community sample. Further study is needed to better clarify the latent structure of this scale and to determine its associations with other similar measures of the affective dimension of psychopathy and with other external correlates. The potential application of this measure in youths remains to be studied.
Dynamic Testing of Children’s Series Completion Ability: Cognitive Flexibility as a Predictor of Performance
Authors: Stad Femke E. , Wiedl Karl H. , Resing Wilma C. M.
Published: September 2016

Dynamic testing aims to explore a child’s potential to learn by assessing improvement after training. In this study we investigated the relationship between performance on a dynamic test of series completion and children’s cognitive flexibility. This was done using a pre-test-trainingpost-test control-group design with 95 children, aged 6-8 years (M = 7;1, SD = 12.5 months). All children were tested with a measurement of cognitive flexibility. Half of the children were trained in series completion according to a graduated prompting model, while the other half only practiced. Based on initial ability and performance change after training, children were classified as non-learner, learner or high performer. The results showed that training improved series completion performance more than practice-only. Cognitive flexibility predicted static pre-test performance and instructional needs during training and might therefore be of importance in the assessment of learning potential.
Effect of Coke Granulometry on the Properties of Carbon Anodes based on Experimental Study and ANN Analysis
Authors: Sarkar Arunima , Kocaefe Duygu , Kocaefe Yasar , Bhattacharyay Dipankar , Morais Brigitte , Coulombe Patrick
Published: September 2016

The available anode-quality petroleum coke is not sufficient to cover the need created by the increase in the world aluminum production. Understanding the consequences of varying calcined coke quality is necessary to possibly compensate for the reduction in coke quality and adjust the anode paste recipe in the subsequent use of coke in order to obtain economically viable production of aluminum. Different fractions of coke particles were mixed to optimize the anode recipe; however, it was laborious to find experimentally the suitable percentage of each fraction in anode paste which would give good anode properties. In this study, Artificial Neural Network (ANN) model was developed for adjusting the granulometry of the raw materials for anode production. Tapped bulk density of dry aggregates was used to predict the anode paste recipe using the ANN method. A new anode recipe (by adjusting the medium fraction in the paste) was proposed based on the predictions of an ANN model, which resulted in improved anode properties.