bluuebunny/crossref_metadata_2025 huggingface dataset:
The MECOVMA Framework: Implementing Machine Learning Under Macroeconomic Volatility for Marketing Predictions
Authors: Muth Manuel
Published: January 2025

The methodological framework introduced in this paper, MECOVMA, is a novel framework that guides the application of Machine Learning specifically for marketing predictions within volatile macroeconomic environments. MECOVMA has been developed in response to the identified gaps displayed by existing frameworks—when it comes to consolidation, relevance, interdisciplinarity, and individuality—and in light of the polycrises occurring in the current decade. The methodology to develop MECOVMA comprises three phases: firstly, synthesizing existing frameworks based on their thematic relevance to select MECOVMA’s process steps; secondly, integrating the evidence provided by a systematic literature review to design the content of these process steps; and thirdly, using an expert evaluation, structured through a qualitative content analysis, to validate MECOVMA’s applicability. This leads to the final framework with four overarching PMECOVMA process steps, guiding the Machine Learning application process in this context with specific tasks. These include, for example, the processing of multidimensional data inputs, complexity reduction in a dynamic environment, and training methods adapted to particular macro-conditions. In addition, features are provided on how Machine Learning can be put into marketing practice, incorporating both narrower statistical- and broader business-oriented evaluations, and iterative feedback loops to mitigate limitations.
Boosted Bio-Oil Production and Sustainable Energy Resource Recovery Through Optimizing Oxidative Pyrolysis of Banana Waste
Authors: Singh Rohit K. , Soni Bhavin , Patel Urvish , Joshi Asim K. , Patel Sanjay K. S.
Published: January 2025

The increasing need for sustainable waste management and abundant availability of banana tree waste, a byproduct of widespread banana cultivation, have driven interest in biomass conversion through clean fuels. This study investigates the oxidative pyrolysis of banana tree waste to optimize process parameters and enhance bio-oil production. Experiments were conducted using a fluidized bed reactor at temperatures ranging from 450 °C to 550 °C, with oxygen to biomass (O/B) ratios varying from 0.05 to 0.30. The process efficiently converts this low-cost, renewable biomass into valuable products and aims to reduce energy intake during pyrolysis while maximizing the yield of useful products. The optimal conditions were identified at an O/B ratio of 0.1 and a temperature of 500 °C, resulting in a product distribution of 26.4 wt% for bio-oil, 20.5 wt% for bio-char, and remaining pyro-gas. The bio-oil was rich in oxygenated compounds, while the bio-char demonstrated a high surface area and nutrient content, making it suitable for various applications. The pyro-gas primarily consisted of carbon monoxide and carbon dioxide, with moderate amounts of hydrogen and methane. This study supports the benefits of oxidative pyrolysis for waste utilization through a self-heat generation approach by partial feed combustion providing the internal heat required for the process initiation that can be aligned with the principles of a circular economy to achieve environmental responsibility.
Cumulative Exposure to Unconventional Natural Gas Development and the Risk of Childhood Cancer: A Registry-Based Case–Control Study
Authors: Talbott Evelyn O. , Arena Vincent C. , Wang Renwei , Wu Fan , Price Natalie , Buchanich Jeanine M. , Hoffman Caroline A. , Bear Todd , Lichtveld Maureen , Yuan Jian Min
Published: January 2025

The rapid growth of unconventional natural gas development (UNGD), also known as hydraulic fracturing, has raised concerns of potential exposures to hazardous chemicals. Few studies have examined the risk of childhood cancer from exposure to UNGD. A case–control study included 498 children diagnosed with leukemia, lymphoma, central nervous system neoplasms, and malignant bone tumors during the period 2010–2019 identified through the Pennsylvania Cancer Registry. Cases were matched to controls using Pennsylvania birth records. For each subject, a new overall UNGD exposure metric was calculated which incorporates both spatial (proximity) and temporal (duration) aspects of well activity. Conditional logistic regression models were used to estimate the risk of combined and individual cancers by overall UNGD exposure, and well proximity. Children with a higher overall UNGD exposure (3rd/4th quartiles) had an increased risk for the four malignancies combined [OR] 1.69 (95% CI 1.01, 2.82) and 1.79 (95% CI 1.00, 3.19) compared to non-exposed children. Overall, individuals living within 0.5 miles of a UNGD site were 3.94 times (95% CI 1.66, 9.30) more likely to develop a malignancy compared to non-exposed children and the risk of lymphoma within 0.5 miles and 0.5–1 miles was also elevated [ORs of 5.05 (95% CI 1.09, 23.39) and 7.71 (95% CI 1.01, 59.00), respectively] compared to non-exposed. Our study found that overall UNGD cumulative activity as well as a proximity to UNGD wells were associated with an increased risk of childhood lymphoma and overall childhood cancers combined.
Exploring Trusted Sources of HPV Vaccine Information Among Mexican American Parents in El Paso, Texas
Authors: Martinez Alyssa A. , Gil Michelle , Shastri Surendranath S. , Frietze Gabriel A.
Published: January 2025

Hispanic populations are disproportionately impacted by HPV-associated cancers. An HPV vaccine is available that protects against 90% of HPV-associated cancers. Understanding the factors associated with HPV vaccine uptake, including identifying whom individuals trust to recommend the HPV vaccine, is an important step toward developing public health interventions for promoting the HPV vaccine among Hispanic people. The purpose of this pilot study was to use a qualitative approach to identify trustworthy messengers to disseminate HPV vaccine information among Mexican American (MA) parents of children of 11–17 years of age. Three 90 min pilot focus groups with three to five participants in each group were conducted. The inclusion criteria included being 18 years of age or older, residing in El Paso, TX, identifying as MA, speaking English, and being a parent of a child between the ages of 11 and 17. Focus groups were conducted with 15 predominately female participants (Mage = 38.46, SD = 5.73; Female = 93.3%). A reoccurring theme throughout all three focus groups was that pediatricians, registered nurses, and pharmacists were identified as the most trusted sources of information. Findings from this study have implications for designing public health interventions that leverage pediatricians, registered nurses, and pharmacists to promote the HPV vaccine among parents.
Interpersonal Perfectionism and Perceived Control’s Influence on the Continuity of Sports Practice in Adolescents
Authors: Pineda-Espejel H. Antonio
Published: January 2025

Based on the theory of planned behavior, the objective was to test a theoretical model that explains the intention to continue practicing sports among adolescents currently involved in sports practice in Mexicali based on factors that generate perceived social pressure to be perfect (perceived descriptive norm) and that lead to internal factors of perceived control (perceived competence, general self-concept, and enjoyment). A battery of questionnaires that measured the study variables was applied to 195 adolescent athletes of both sexes. The causal model with observed variables rejected part of the hypothesis since the athletes’ perception that their parents impose high performance expectations on them and that they criticize them when these expectations are not achieved was not associated with the athletes’ perceived competence. Meanwhile, perceived coach pressure was positively associated with perceived competence, suggesting that it may be adaptive. This also suggests that perceived competence favors the intention to continue practicing sports both directly and indirectly through self-concept and enjoyment. In conclusion, boys involved in sports will have the intention to continue practicing if they perceive that their closest social references demand that they be perfect in the sport and when they perceive themselves to be able to do it effectively. Meanwhile, girls will have the intention to continue in sports practice if, in addition, they have a better general self-concept and enjoy the activity. Therefore, an important task for coaches, in order to encourage the continuation of sport in adolescents, is to promote the perception of qualities, skills and abilities toward sport.
Performance Evaluation and Optimization of 3D Gaussian Splatting in Indoor Scene Generation and Rendering
Authors: Fang Xinjian , Zhang Yingdan , Tan Hao , Liu Chao , Yang Xu
Published: January 2025

This study addresses the prevalent challenges of inefficiency and suboptimal quality in indoor 3D scene generation and rendering by proposing a parameter-tuning strategy for 3D Gaussian Splatting (3DGS). Through a systematic quantitative analysis of various performance indicators under differing resolution conditions, threshold settings for the average magnitude of spatial position gradients, and adjustments to the scaling learning rate, the optimal parameter configuration for the 3DGS model, specifically tailored for indoor modeling scenarios, is determined. Firstly, utilizing a self-collected dataset, a comprehensive comparison was conducted among COLLI-SION-MAPping (abbreviated as COLMAP (V3.7), an open-source software based on Structure from Motion and Multi-View Stereo (SFM-MVS)), Context Capture (V10.2) (abbreviated as CC, a software utilizing oblique photography algorithms), Neural Radiance Fields (NeRF), and the currently renowned 3DGS algorithm. The key dimensions of focus included the number of images, rendering time, and overall rendering effectiveness. Subsequently, based on this comparison, rigorous qualitative and quantitative evaluations are further conducted on the overall performance and detail processing capabilities of the 3DGS algorithm. Finally, to meet the specific requirements of indoor scene modeling and rendering, targeted parameter tuning is performed on the algorithm. The results demonstrate significant performance improvements in the optimized 3DGS algorithm: the PSNR metric increases by 4.3%, and the SSIM metric improves by 0.2%. The experimental results prove that the improved 3DGS algorithm exhibits superior expressive power and persuasiveness in indoor scene rendering.
Dietary Taurine Regulation of the Intestinal Microbiome in Chinese Stripe-Necked Turtle (Mauremys sinensis)
Authors: Yuan Yue , Niu Xin , Hao Chenguang , Liang Lingyue , Huang Zubin , Wang Dongmei , Hong Meiling , Ding Li
Published: January 2025

Taurine is essential for sustaining the body’s physiological equilibrium and is extensively utilized as a dietary supplement and immune system enhancer for aquatic creatures. The gut microbiota serves as a vital health indicator in animals. In this study, our goal was to evaluate the effects of dietary taurine on the gut microbiome of Chinese stripe-necked turtles (Mauremys sinensis). Turtles were evenly divided into three supplementation groups: a control group with no taurine in the diet, a low group with 0.1% taurine, and a high group with 0.4% taurine. High-throughput sequencing was employed to analyze the gut microbiome’s composition and structure. The results showed that the impact of taurine supplementation on the α-diversity and β-diversity of the gut microbiome was not statistically significant. At the phylum level, Firmicutes and Bacteroidetes predominated the gut microbiome. At the genus level, three beneficial bacteria, Clostridium_sensu_stricto_13, Pygmaiobacter, and Terrisporobacter showed significant differences under different levels of taurine supplementation and increased in abundance with the supplementation of taurine, while the harmful bacterium Brucella decreased in abundance with the addition of taurine and exhibited significant differences. Furthermore, LEfSe analysis and functional predictions highlighted significant variations in the functional traits of gram-positive intestinal bacteria among the different taurine supplementation levels. These findings imply that dietary taurine may alter the intestinal microbiome structure in Chinese stripe-necked turtles, offering valuable insights for the scientific assessment of taurine’s health benefits as a feed additive and potentially guiding the formulation of more informed and healthier feeding practices.
Special Issue: “New Trends in Diabetes, Hypertension, and Cardiovascular Diseases—2nd Edition”
Authors: Wang Yutang , Magliano Dianna J.
Published: January 2025

Cardiovascular diseases (CVDs) encompass a range of conditions affecting both the heart (e.g., coronary heart disease and heart failure [1]) and blood vessels (e.g., cerebrovascular disease [2] and peripheral artery disease [3]) [...]
Bioactive Compounds from Vegetal Organs of Taraxacum Species (Dandelion) with Biomedical Applications: A Review
Authors: Tanasa (Acretei) Maria-Virginia , Negreanu-Pirjol Ticuta , Olariu Laura , Negreanu-Pirjol Bogdan-Stefan , Lepadatu Anca-Cristina , Anghel (Cireasa) Larisa , Rosoiu Natalia
Published: January 2025

Taraxacum officinale (dandelion) is a perennial flowering plant of the Asteraceae family that has spread globally and is well-known for its traditional uses. The aim of this work is to provide a detailed review of scientific literature on the genus Taraxacum from the last two decades, with particular emphasis on the biological and pharmacological characteristics of dandelions. The traditional use of Taraxacum species and their potential use in medicine are assessed. In addition, individual papers describing principal pathways and molecules modulated by Taraxacum in antitumoral, anti-inflammatory, antidiabetic, hepatoprotective, immunomodulatory, antimicrobial, and antioxidant activities are presented. This review of phytochemical studies reveals that dandelions contain a wide range of bioactive compounds, such as polyphenols, phytosterols, flavonoids, carotenoids, terpene, and coumarins, whose biological activities are actively explored in various areas of human health, some constituents having synergistic activities, including antioxidant, antimicrobial, anti-inflammatory and anticancer activities. The study provides a screening of Taraxacum sp. chemical composition, an assessment of the main pharmacological properties, and a description of relevant studies supporting the use of dandelion for its particularly valuable and diversified therapeutic potential in different diseases.
An Event Causality Identification Framework Using Ensemble Learning
Authors: Wang Xiaoyang , Luo Wenjie , Yang Xiudan
Published: January 2025

Event causality identification is an upstream operation for many tasks, including knowledge graphs and intelligent question-and-answer systems. The latest models introduce external knowledge and then use deep learning for causality prediction. However, event causality recognition still faces problems such as data imbalance and insufficient event content richness. Additionally, previous frameworks have utilized a single model, but these frequently produce unsatisfactory outcomes such as lower precision rates and lower recall rates. We propose the concept of ensemble learning, which combines multiple models to achieve frameworks that perform as well as or better than the latest models. This framework combines the advantages of Mamba, a temporal convolutional network, and graph computation to identify event causality more effectively and accurately. After comparing our framework to standard datasets, our F1-scores (measures of model accuracy) are essentially the same as those of the state-of-the-art (SOTA) methods on one dataset.
First Principles Study of Electronic and Optical Properties of Cadmium-Tin-Oxide
Authors: Alruqi Adel Bandar
Published: January 2025

Cadmium-tin-oxide (CTO), also referred to as cadmium stannate (Cd2SnO4), is known for its interesting electrical, electronic, and optical properties, making it useful in various applications such as in transparent conducting oxides for optoelectronic devices and also in photovoltaic applications. While its properties have been investigated experimentally, there is not much record in the literature on the computational study of the electronic and optical properties of CTO. This study employed density functional theory to explore the two properties of CTO. The hybrid functionals were used to widen the band gap from 0.381 eV (for PBE) to 3.13 eV, which replicates the experimental values very well. The other properties obtained were a refractive index of 2.53, absorption coefficient of 1.43 × 104 cm−1, and dielectric constant of 6.401 eV. The optical energy loss of 0.00691 that was investigated for the first time in this work adds to the literature on the properties of CTO. However, the electrical properties of CTO, which also play a key role in the working of optoelectronic devices, need to be investigated.
Choroidal Remodeling After Subthreshold Micropulse Laser in Chronic Central Serous Chorioretinopathy: Short-Term Outcomes
Authors: Viggiano Pasquale , Scotti Giacomo , Termite Alba Chiara , Savastano Alfonso , Boscia Giacomo , Clemente Arcangelo , Salvelli Antonio , Giancipoli Ermete , Pignatelli Francesco , Evangelista Federica , Alessio Giovanni , Boscia Francesco
Published: January 2025

Objectives: To evaluate the effects of subthreshold micropulse laser treatment (SMLT) on choroidal architecture in chronic central serous chorioretinopathy (CSC) and their correlations with functional outcomes. Methods: This retrospective study included 48 eyes with chronic CSC that were treated with 577 nm SMLT. The choroidal thickness (CT); Sattler’s layer and choriocapillaris complex thickness (SLCCT); Haller’s layer thickness (HLT); subretinal fluid (SRF); and best-corrected visual acuity (BCVA) were assessed at baseline and at 2 months post treatment. Results: At 2 months, the SLCCT increased from 185.92 ± 80.89 μm to 214.17 ± 83.36 μm (p = 0.023), and the total CT increased from 444.46 ± 80.43 μm to 484.33 ± 93.19 μm (p = 0.002). The SRF height decreased from 140.38 ± 95.89 μm to 57.58 ± 63.54 μm (p < 0.001), with complete resolution in 79.2% of cases. The BCVA improved from 0.41 ± 0.48 to 0.22 ± 0.30 logMAR (p < 0.001). Changes in the SLCCT correlated negatively with BCVA changes (r = −0.48, p = 0.025) and positively with total CT changes (r = 0.687, p < 0.001). Conclusions: SMLT induces significant choroidal remodeling in chronic CSC, particularly affecting the Sattler–Bruch layer complex. The increase in the SLCCT correlates with visual improvement, challenging the conventional understanding of choroidal thinning in CSC treatment.
Efficacy of Larval Therapy for Wounds: A Systematic Review and Meta-Analysis
Authors: Lam Thao , Beraja Gabriela E. , Lev-Tov Hadar
Published: January 2025

Background/Objective: Larval therapy (LT), an intervention using live fly larvae to remove necrotic tissue and promote healing, has regained attention in order to address the growing need for chronic wound management. LT was approved by the Food and Drug Administration (FDA) in 2004 to treat difficult-to-heal wounds; however, LT remains an underutilized therapy. To evaluate efficacy of LT in a systematic review and meta-analysis of wound outcomes from randomized controlled trials (RCTs). Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to conduct a literature search across five databases for published and unpublished RCTs comparing LT to conventional therapy. A meta-analysis was performed to evaluate LT’s effect on debridement as the primary outcome. Wound healing, bioburden, and treatment-related pain were analyzed as secondary outcomes. Bias was assessed using Cochrane’s Risk-of-Bias 2 tool. Results: Eight RCTs were included in the review. The meta-analysis suggested that LT may be more effective for complete wound debridement (RR = 2.17), though this result was not significant (p = 0.09). The analysis is limited by the small number of studies and the high heterogeneity between studies (I2 = 75%). There were no significant differences in the healing rate, antimicrobial effects, or pain compared to conventional therapy. There is a moderate risk for bias in the selection of reported outcomes. Conclusions: LT is as effective as conventional therapy for debridement and may be an alternative for patients who cannot tolerate traditional methods. LT patients may experience similar levels of pain, but LT does not worsen wound healing or infection compared to those receiving routine care.
Immunophenotyping of T Cells in Lung Malignancies and Cryptogenic Organizing Pneumonia
Authors: Yanagihara Toyoshi , Hata Kentaro , Matsubara Keisuke , Kunimura Kazufumi , Suzuki Kunihiro , Tsubouchi Kazuya , Ikegame Satoshi , Fukui Yoshinori , Okamoto Isamu
Published: January 2025

Background: Lung malignancies, including cancerous lymphangitis and lymphomas, can mimic interstitial lung diseases like cryptogenic organizing pneumonia (COP) on imaging, leading to diagnostic delays. We aimed to identify potential biomarkers to distinguish between these conditions. Methods: We analyzed bronchoalveolar lavage fluid from 8 patients (4 COP, mean age 59.8 ± 13.5 years; 4 lung malignancies including 2 cancerous lymphangitis, 1 MALT lymphoma, and 1 diffuse large B cell lymphoma, mean age 67.8 ± 4.5 years) using mass cytometry with 35 T cell markers. Data were analyzed using principal component analysis (PCA) and unsupervised Citrus clustering. Results: PCA of T cell marker intensities effectively separated the two groups, with IL-2Rα, PD-L2, CD45RA, CD44, and OX40 being the top discriminating markers. Citrus analysis showed a significant increase in the CD16+ CD4+ and CD16+ CD8+ T cell populations in the COP group compared to lung malignancies. Conclusions: Our findings reveal distinct T cell immunophenotypes in COP versus lung malignancies, particularly increased CD16+ T cells in COP, which could serve as potential diagnostic biomarkers.
Redirection of Care for Neonates with Hypoxic-Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Authors: Gubler Deborah F. L. , Wenger Adriana , Boos Vinzenz , Liamlahi Rabia , Hagmann Cornelia , Brotschi Barbara , Grass Beate
Published: January 2025

Background/Objectives: Hypoxic-ischemic encephalopathy (HIE) in late preterm and term neonates accounts for neonatal mortality and unfavorable neurodevelopmental outcomes in survivors despite therapeutic hypothermia (TH) for neuroprotection. The circumstances of death in neonates with HIE, including involvement of neonatal palliative care (NPC) specialists and neurodevelopmental follow-up at 18–24 months in survivors, warrant further evaluation. Methods: A retrospective multicenter cohort study including neonates ≥ 35 weeks gestational age with moderate to severe HIE receiving TH, registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2021. Neurodevelopmental follow-up at 18–24 months in survivors was assessed. The groups of survivors and deaths were compared regarding perinatal demographic and HIE data. Prognostic factors leading to redirection of care (ROC) were depicted. Results: A total of 137 neonates were included, with 23 (16.8%) deaths and 114 (83.2%) survivors. All but one death (95.7%) occurred after ROC, with death on a median of 3.5 (2–6) days of life. Severe encephalopathy was indicated by a Sarnat score of 3 on admission, seizures were more frequent, and blood lactate values were higher on postnatal days 1 to 4 in neonates who died. Lactate in worst blood gas analysis (unit-adjusted odds ratio 1.25, 95% CI 1.02–1.54, p = 0.0352) was the only variable independently associated with ROC. NPC specialists were involved in one case. Of 114 survivors, 88 (77.2%) had neurodevelopmental assessments, and 21 (23.9%) of those had unfavorable outcomes (moderate to severe disability). Conclusions: Death in neonates with moderate to severe HIE receiving TH almost exclusively occurred after ROC. Parents thus had to make critical decisions and accompany their neonate at end-of-life within the first week of life. Involvement of NPC specialists is encouraged in ROC so that there is continuity of care for the families whether the neonate survives or not.
Status and Evolving Characteristics of Marine Spatial Resources in the Hangzhou Bay Area of Zhejiang Province, China
Authors: Wang Peng , Zhou Jingru , Zheng Kaixuan , Lin Xia , Tan Mou Leong , Shi Jingchao , Lin Xingwen , Yue Xihe , Ma Xu , Zhang Fei
Published: January 2025

The 20th Party Congress initiated efforts to strengthen maritime power and advance marine ecological civilization, which is essential for promoting sustainable development. To achieve this goal, this study combines field measurements, drone imagery, and high-resolution remote sensing data, using GIS technology to analyze changes in marine resources in Hangzhou Bay and assess marine area usage, intertidal zone area changes, and coastline erosion. The key findings show that the industrial sector accounts for the largest usage of marine area, with the industrial sea area growing by 110.3% from 2018 to 2020. The diversity index for marine area usage in Hangzhou Bay has remained stable, consistently at 0.6 and above over the past five years. The continental coastline of Hangzhou Bay has shown a decreasing trend in recent years from 2018 and 2021, with a total intertidal area of Hangzhou Bay decreased by 73.44 km2, where the overall shoal pattern in Hangzhou Bay remained relatively stable from 2008 to 2016. Erosion has been the predominant force, with maximum erosion surpassing 3 m and causing significant spatial changes. Between 2012 and 2016, the total erosion volume reached 192,473.74 × 106 m3, with an average annual erosion rate of 48,118.44 × 106 m3. This process has led to a gradual reduction in the size of affected areas over the period from 2001 to 2021. This research provides valuable insights for authorities to make informed decisions regarding the management of marine spatial resources in Hangzhou Bay.
Anatomical Adaptations of Halophyte Leaves (Nitraria retusa [Forsskal] Asch. and Atriplex halimus L.) in Response to Cement Dust Pollution in Arid Environments
Authors: Krir Nouha , Guedri Mounira Mkaddem , Romdhane Mehrez , Alshaqha Manel Abdullah
Published: January 2025

This study investigates the anatomical adaptations of leaves from two halophyte species, Nitraria retusa (Forsskal) Asch. and Atriplex halimus L., in response to pollutants from a cement factory and human activities. In industrial areas, these plants absorb pollutants through their leaf surfaces, including Cu, Zn, and Pb. The two species were examined for anatomical changes under air pollution, and key factors including leaf blade thickness, palisade parenchyma cell height, spongy parenchyma cell diameter, epidermal characteristics, and stomatal traits were assessed. Under pollution, the leaves displayed smaller and denser stomata and idioblasts in the palisade and spongy parenchyma. These anatomical responses suggest that N. retusa and A. halimus could be effective bioindicators for detecting cement dust pollutants. Their leaf relative water content (RWC) exhibited a range of values: 70.1% and 87% for N. retusa and 64.8% to 74.2% for A. halimus on the highly polluted site (S1) and the control site (S4), respectively. Notably, a statistically significant site effect was observed (p > 0.01), confirming previous studies, and indicating reduced leaf relative water content (RWC) values in plants exposed to heavy metals like Cd and Pb. Heavy metals can lead to mineralization by binding to cell walls, altering their physicochemical properties and plasticity. Furthermore, significant correlations between specific heavy metals and histological parameters in A. halimus leaves indicated potential interactions between metal composition and leaf structure, highlighting their role in modulating anatomical adaptations. The correlation of leaf thickness, upper epidermal thickness, and stomatal density with Zn and Pb levels underlines the importance of these anatomical features in heavy metal accumulation and retention in plant tissues.
Visual Performance After Bilateral Implantation of a New Enhanced Monofocal Hydrophobic Acrylic Intraocular Lens Targeted for Mini-Monovision
Authors: Scarfone Hugo A. , Rodríguez Emilia C. , Riera Jerónimo , Rufiner Maira , Charles Martín
Published: January 2025

Background: The aim of this study was to evaluate visual outcomes and patient satisfaction after bilateral implantation of a new hydrophobic acrylic intraocular lens called Clareon (Alcon) using the mini-monovision technique. Methods: A single-center, prospective, nonrandomized study was conducted in Tandil (Buenos Aires, Argentina), including patients scheduled for cataract surgery. To achieve mini-monovision, the spherical equivalent was calculated between −0.25 and +0.25 D for the dominant eye, and between −0.75 and −1.00 D for the non-dominant eye. The main outcomes were uncorrected distance visual acuity (UDVA) and uncorrected intermediate visual acuity (UIVA) evaluated at 66 cm. A secondary outcome, patient satisfaction, was assessed using the CatQuest-9SF questionnaire. Results: The mean binocular UDVA was 0.01 ± 0.05 logMAR three months after surgery, while the mean binocular UIVA was 0.20 ± 0.06 logMAR. The postoperative mean spherical equivalent in the dominant eye was −0.27 ± 0.12, and in the non-dominant eye was −0.87 ± 0.25. Before surgery, the CatQuest-9SF questionnaire revealed that 83.33% of patients were dissatisfied with their vision during daily activities. Over 50% reported significant difficulties with reading newspapers, sewing, and reading TV subtitles. Additionally, 66.6% struggled with recognizing faces, 50% with seeing product prices, and 50% with walking on uneven ground. Post-surgery, most patients experienced improved vision for daily tasks, with no reports of high dissatisfaction or significant difficulties. Patients were quite satisfied with their vision for hobbies and TV subtitles, and very satisfied (90%) with seeing supermarket prices. Conclusions: patients implanted with a new enhanced monofocal IOL using the mini-monovision technique showed improved distance and intermediate visual acuity, reduced need for glasses, and expressed a high degree of satisfaction.
A Carbon Nanotube Transistor Based on Buried-Gate Structure
Authors: Li Haiou , Liao Yuanmei , Zhang Fabi , Sun Tangyou , Liu Xingpeng , Chen Shouwei
Published: January 2025

From the discovery of carbon nanotubes to the ability to prepare high-purity semiconductor carbon nanotubes in large quantities, the large-scale fabrication of carbon nanotube transistors (CNT) will become possible. In this paper, a carbon nanotube transistor featuring a buried-gate structure, employing an etching process to optimize the surface flatness of the device and enhance its performance, is presented. This CNT thin-film transistor has a current switching ratio of 104, a threshold voltage of around 1 V, and a mobility that can reach 6.95 cm2/V·s, indicating excellent electrical performance. The device achieves operational targets at low voltage, facilitating the development of small and portable electronic devices.
Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma
Authors: Alpízar Salazar Melchor , Olguín Reyes Samantha Estefanía , Medina Estévez Andrea , Saturno Lobos Julieta Alejandra , De Aldecoa Castillo Jesús Manuel , Carrera Aguas Juan Carlos , Alaniz Monreal Samary , Navarro Rodríguez José Antonio , Alpízar Sánchez Dulce María Fernanda
Published: January 2025

Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) stems from disrupted lipid metabolism in the liver, often linked to obesity, type 2 diabetes, and dyslipidemia. In Mexico, where obesity affects 36.9% of adults, MASLD prevalence has risen, especially with metabolic syndrome affecting 56.31% by 2018. MASLD can progress to Metabolic Dysfunction-Associated Steatohepatitis (MASH), affecting 5.27% globally, leading to severe complications like cirrhosis and hepatocellular carcinoma. Background: Visceral fat distribution varies by gender, impacting MASLD development due to hormonal influences. Insulin resistance plays a central role in MASLD pathogenesis, exacerbated by high-fat diets and specific fatty acids, leading to hepatic steatosis. Lipotoxicity from saturated fatty acids further damages hepatocytes, triggering inflammation and fibrosis progression in MASH. Diagnosing MASLD traditionally involves invasive liver biopsy, but non-invasive methods like ultrasound and transient elastography are preferred due to their safety and availability. These methods detect liver steatosis and fibrosis with reasonable accuracy, offering alternatives to biopsy despite varying sensitivity and specificity. Conclusions: MASLD as a metabolic disorder underscores its impact on public health, necessitating improved awareness and early management strategies to mitigate its progression to severe liver diseases.
Comparative Analysis of Chemical Composition and Antibacterial Activity of Essential Oils from Five Varieties of Lavender Extracted via Supercritical Fluid Extraction
Authors: Lin Lijing , Lv Zhencheng , Wang Meiyu , Kan Ankang , Zou Songling , Wu Bin , Guo Limin , Edirs Salamet , Liu Jiameng , Zhu Lin
Published: January 2025

This study aimed to determine the chemical composition of five Lavender essential oils (LEOs) using the gas chromatography–mass spectroscopy technique and to assess their antibacterial activity against four marine Vibrio species, including Shewanella algae, Shewanella maridflavi, Vibrio harveyi, and Vibrio alginolyticus. Sensitivity tests were performed using the disk diffusion and serial dilution methods. The results showed that all five LEOs exhibited antibacterial activity against the four tested marine Vibrio species. The antibacterial activities of all five LEOs were above moderate sensitivity. The five LEOs from French blue, space blue, eye-catching, and true Lavender showed high sensitivity, particularly against Shewanella maridflavi. The compounds of LEOs from different varieties of Lavender were similar and mainly comprised linalool, linalyl acetate, eucalyptol, and isoborneol. Different varieties of LEOs possessed unique components besides common components, and the percentage of each one was different, which led to different fragrance loads. The major fragrances were lily of the valley, an aromatic compound fragrance, and an herbal fragrance. The antibacterial activity of LEO from eye-catching Lavender was better than that of others, which could provide a reference for its application in the prevention and control of marine Vibrio spp. and the development of antibacterial products.
Increased Oxidative and Nitrative Stress and Decreased Sex Steroid Relaxation in a Vitamin D-Deficient Hyperandrogenic Rodent Model—And a Validation of the Polycystic Ovary Syndrome Model
Authors: Sziva Réka Eszter , Kollarics Réka , Pál Éva , Bányai Bálint , Korsós-Novák Ágnes , Fontányi Zoltán , Magyar Péter , Süli Anita , Nádasy György L. , Ács Nándor , Horváth Eszter Mária , Hadjadj Leila , Várbíró Szabolcs
Published: January 2025

Background/Objectives: Both hyperandrogenism (HA) and vitamin D deficiency (VDD) can separately lead to impaired vascular reactivity and ovulatory dysfunction in fertile females. The aim was to examine the early interactions of these states in a rat model of PCOS. Methods: Four-week-old adolescent female rats were divided into four groups: vitamin D (VD)-supplemented (n = 12); VD-supplemented and testosterone-treated (n = 12); VDD- (n = 11) and VDD-and-testosterone-treated (n = 11). Animals underwent transdermal testosterone treatment for 8 weeks. Target VD levels were achieved with oral VD supplementation and a VD-free diet. Estrous cycles were followed by vaginal smear, and quantitative histomorphometric measurements of the ovaries were also taken. In the 8th week, testosterone- and estrogen-induced relaxation of coronary arterioles was examined with pressure angiography. Estrogen receptor (ER) density and oxidative and nitrative stress parameters (Poly-(ADP-Ribose)-Polymerase and 3-nitrotyrosine) in the vessel wall were investigated with immunohistochemistry. Results: VDD caused impaired estrous cycles, and testosterone caused anovulatory cycles (the cycles were stopped at the diestrous phase). VDD combined with testosterone treatment resulted in reduced testosterone and estrogen vasorelaxation, lower ER density, and higher oxidative and nitrative stress in the vessel wall. Conclusions: PCOS with vitamin D deficiency may be associated with increased oxidative–nitrative stress in coronary arterioles. This oxidative and nitrative stress, potentially caused by hyperandrogenism and/or vitamin D deficiency, could impair estrogen-induced relaxation of the coronary arterioles, possibly by decreasing NO bioavailability and disrupting the estrogen-induced relaxation pathway.
Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract
Authors: Mudrić Jelena , Đekić Ljiljana , Krgović Nemanja , Medarević Đorđe , Šavikin Katarina , Radan Milica , Ćujić Nikolić Nada , Ilić Tijana , Vidović Bojana , Đuriš Jelena
Published: January 2025

Background/Objectives: This study aimed to develop gastroretentive tablets based on mucoadhesive–floating systems with encapsulated gentian (Gentiana lutea, Gentianaceae) root extract to overcome the low bioavailability and short elimination half-life of gentiopicroside, a dominant bioactive compound with systemic effect. The formulation also aimed to promote the local action of the extract in the stomach. Methods: Tablets were obtained by direct compression of sodium bicarbonate (7.5%) and solid lipid microparticles (92.5%), which were obtained with lyophilizing double emulsions. A quality by design (QbD) was employed to evaluate the impact of formulation factors and processing parameters on emulsion viscosity, powder characteristics (moisture content, encapsulation efficiency, flowability), and tablet characteristics (floating lag time, gentiopicroside release, and assessment of dispersibility during in vitro dissolution). Results: The trehalose content and high-shear-homogenization (HSH) time of primary emulsion were critical factors. Trehalose content positively influenced emulsion viscosity, moisture content, floating lag time, encapsulation efficiency, and the release rate of gentiopicroside. HSH time positively affected powder stability and negatively gentiopicroside release. The selected powder had a high gentiopicroside encapsulation efficiency (95.13%), optimal stability, and good flowability. The developed tablets exhibited adequate floating lag time (275 s), mucoadhesive properties, and gentiopicroside biphasic release (29.04% in 45 min; 67.95% in 6 h). Furthermore, the optimal tablet formulation remained stable for 18 months and was primarily digested by duodenal enzymes. Conclusions: Dual-mechanism gastroretentive tablets with encapsulated gentian root extract were successfully developed. The in vitro digestion study demonstrated that the optimal formulation effectively resisted gastric enzymes, ensuring the release of its contents in the small intestine, even in the case of premature gastric evacuation.
Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostases
Authors: Zhou Min , Wu Yuting , Yang Yuchen , Yuan Yan , Lin Junnan , Lin Long , Li Zhou
Published: January 2025

White clover (Trifolium repens) is an excellent perennial cold-season ground-cover plant for municipal landscaping and urban greening. It is, therefore, widely distributed and utilized throughout the world. However, poor salt tolerance greatly limits its promotion and application. This study aims to investigate the difference in the mechanism of salt tolerance in relation to osmotic adjustment, enzymatic and nonenzymatic antioxidant defenses, and organic metabolites remodeling between salt-tolerant PI237292 (Trp004) and salt-sensitive Korla (KL). Results demonstrated that salt stress significantly induced chlorophyll loss, water imbalance, and accumulations of malondialdehyde (MDA), hydrogen peroxide (H2O2), and superoxide anion (O2.−), resulting in reduced cell membrane stability in two types of white clovers. However, Trp004 maintained significantly higher leaf relative water content and chlorophyll content as well as lower osmotic potential and oxidative damage, compared with KL under salt stress. Although Trp004 exhibited significantly lower activities of superoxide dismutase, peroxidase, catalase, ascorbate peroxidase, monodehydroasorbate reductase, dehydroascorbate reductase, and glutathione reductase than KL in response to salt stress, significantly higher ascorbic acid (ASA), dehydroascorbic acid (DHA), glutathione (GSH), glutathione disulfide (GSSG), ASA/DHA, and GSH/GSSG were detected in Trp004. These findings indicated a trade-off relationship between antioxidant enzymes and nonenzymatic antioxidants in different white clover genotypes adapting to salt stress. In addition, Trp004 accumulated more organic acids (glycolic acid, succinic acid, fumaric acid, malic acid, linolenic acid, and cis-sinapic acid), amino acids (serine, l-allothreonine, and 4-aminobutyric acid), sugars (tagatose, fructose, glucoheptose, cellobiose, and melezitose), and other metabolites (myo-inositol, arabitol, galactinol, cellobiotol, and stigmasterol) than KL when they suffered from the same salt concentration and duration of stress. These organic metabolites helped to maintain osmotic adjustment, energy supply, reactive oxygen species homeostasis, and cellular metabolic homeostasis with regard to salt stress. Trp004 can be used as a potential resource for cultivating in salinized soils.
Morphological, Physiological, and Molecular Responses to Heat Stress in Brassicaceae
Authors: Batool Iram , Ayyaz Ahsan , Qin Tongjun , Wu Xiaofen , Chen Weiqi , Hannan Fakhir , Zafar Zafar Ullah , Naeem Muhammad Shahbaz , Farooq Muhammad Ahsan , Zhou Weijun
Published: January 2025

Food security is threatened by global warming, which also affects agricultural output. Various components of cells perceive elevated temperatures. Different signaling pathways in plants distinguish between the two types of temperature increases, mild warm temperatures and extremely hot temperatures. Given the rising global temperatures, heat stress has become a major abiotic challenge, affecting the growth and development of various crops and significantly reducing productivity. Brassica napus, the second-largest source of vegetable oil worldwide, faces drastic reductions in seed yield and quality under heat stress. This review summarizes recent research on the genetic and physiological impact of heat stress in the Brassicaceae family, as well as in model plants Arabidopsis and rice. Several studies show that extreme temperature fluctuations during crucial growth stages negatively affect plants, leading to impaired growth and reduced seed production. The review discusses the mechanisms of heat stress adaptation and the key regulatory genes involved. It also explores the emerging understanding of epigenetic modifications during heat stress. While such studies are limited in B. napus, contrasting trends in gene expression have been observed across different species and cultivars, suggesting these genes play a complex role in heat stress tolerance. Key knowledge gaps are identified regarding the impact of heat stress during the growth stages of B. napus. In-depth studies of these stages are still needed. The profound understanding of heat stress response mechanisms in tissue-specific models are crucial in advancing our knowledge of thermo-tolerance regulation in B. napus and supporting future breeding efforts for heat-tolerant crops.
Borehole Failure Mechanics and Influencing Factors in a Gas-Bearing Soft Coal Seam Under Complex Geological Conditions
Authors: Chen Xuexi , Yan Zhilong , Hu Jiaying , Yang Tao , Sun Jihong , Tao Yunqi , Chen Xingyu
Published: January 2025

The present research focuses on the mechanical properties and stress evolution of gas-bearing soft coal seams during drilling, which are affected by a multitude of complex factors such as high ground stress, gas pressure, and pre-existing fractures. In this study, a combination of PFC2D (Particle Flow Code in 2 Dimensions) numerical simulation and theoretical analysis is employed to investigate the borehole mechanics and fracture evolution characteristics under diverse complex conditions and to determine the factors influencing different forms of borehole failure in soft coal seams. The principal outcomes are as follows: (1) At a horizontal displacement of 0.1 m from the borehole orifice of the soft coal seam, a stress peak value of 13.9 MPa is attained; the peak value of the coal body contact force is 15.8 MPa; the peak value of the displacement is 0.008 m; and the porosity of the coal body around the borehole ranges from 0.14 to 0.35. (2) With an increase in the number of pre-existing fractures, the inclination progressively aligns with that of the pre-existing fractures. Maximum values of contact force (5.13–51.9 MPa), stress (3.19–37.2 MPa), shape dimension, and fracture angle (140–150°) are achieved under the highest lateral pressure coefficient and gas pressure (1.5 MPa). (3) The borehole energy is directly proportional to the number of pre-existing fractures, the lateral pressure coefficient, and gas pressure. The number of pre-existing fractures has the most significant impact on the damage degree, followed by the lateral pressure coefficient and then the gas pressure. (4) Two types of failure are identified: fracture-dominated failure, which is controlled by the geometric distribution of pre-existing fractures, and stress-dominated failure, wherein the failure zone gradually extends both upward and downward with an increasing lateral pressure coefficient.