bluuebunny/crossref_metadata_2025 huggingface dataset:
Public preferences for online medical consultations in China: a discrete choice experiment
Authors: Wang Pei , Huang Yuankai , Li Haotao , Xi Xiaoyu
Published: December 2023

Background

Online medical consultation (OMC) is significant to promote the utilization and accessibility of healthcare resources and save time on consultation. However, the usage and public acceptance rates of it are still low in China. Meanwhile, few studies have focused on consumers’ demand of OMC services. This study aims to identify attributes that influence users’ preference for OMC services, quantify the value of these characteristics, and compare their relative importance.

Methods

A nationwide discrete choice experiment was conducted to survey Chinese residents’ preference choices for six attributes of OMC services. Conditional logit model and mixed logit model were used to analyze respondents’ preference. Willingness to pay and heterogeneity were estimated by the mixed logit model.

Results

A total of 856 respondents completed the study, and 668 questionnaires passed the consistency test. All of 6 attributes in the study were statistically significant except for “Doctor’s professional title – Associate Senior.” When choosing OMC services, respondents preferred to spend as little time and money as possible on a large online medical platform to consult a high-rated physician with a senior title from a well-known Grade-A tertiary hospital. Besides, respondents valued doctor’s evaluation score most and were willing to pay ¥107 to obtain the services of higher-scored doctors.

Conclusion

The study measured Chinese residents’ preferences for six attributes of OMC and showed the heterogeneity of attributes among subgroups. Our findings suggested that OMC services providers should reduce the customers’ waiting time, improve the quality of services and enhance professional skills to meet the customers’ requirements. More research on preferences for OMC needs to be conducted in China, especially for key populations such as patients with chronic diseases.
Discrepancy in diagnoses of diabetes and prediabetes using fasting plasma glucose and glycosylated hemoglobin and the underdiagnosis by ICD-10 coding: data from a tertiary hospital in Thailand
Authors: Poorirerngpoom Napalai , Ganokroj Poranee , Vorayingyong Arnond , Rattananupong Thanapoom , Pusavat Jennifer , Supasiri Thanan
Published: December 2023

Background

Early detection of prediabetes and diabetes better prevents long-term health complications. FPG and HbA1c levels are some common laboratory tests utilized as tools to diagnose diabetes and prediabetes, but the agreement rate between these two diagnostic tests varies, which could lead to underdiagnosis and thus undertreatment. This study aimed to analyze the agreement rate between FPG and HbA1c, as well as the physicians’ accuracy of using these results to make a prediabetes or diabetes diagnosis through ICD-10 coding at a tertiary care hospital in Bangkok, Thailand.

Methods

A cross-sectional descriptive study was conducted using secondary data collected in a tertiary hospital’s check-up clinic from August 16, 2019 to June 30, 2022 to study the prevalence and diagnosis of diabetes and prediabetes, determined through FPG and HbA1c laboratory results. We analyzed the two laboratory tests’ diagnosis agreement rate and the physicians’ accuracy of diagnosing diabetes and prediabetes in ICD-10 coding using the FPG and HbA1c results.

Results

Among 8,024 asymptomatic participants, the period prevalence diagnosed through laboratory results was 5.8% for diabetes and 19.8% for prediabetes. Diabetes and prediabetes prevalence based on laboratory data differs from that of ICD-10 coding data. Specifically, 79.6% of diabetes patients and 32.3% of prediabetes patients were coded using the ICD-10 coding system. 4,094 individuals had both FPG and HbA1c data. The agreement rate for diagnosing diabetes and prediabetes between the two laboratory results is 89.5%, with Kappa statistics of 0.58. Using only one of the two laboratory results would have missed a substantial number of patients.

Conclusion

Our findings highlight screening test discrepancies and underdiagnosis issues that impede diagnostic accuracy enhancement and refined patient management strategies. Early diagnoses of prediabetes and diabetes, especially before symptoms arise, could increase health consciousness in individuals, thereby enabling the implementation of lifestyle modifications and prevention of serious health complications. We emphasize the importance of diagnosing these conditions using both FPG and HbA1c, along with subsequent accurate ICD-10 coding. Even though some hospitals lack certified HbA1c testing, we suggest enhancing the availability of HbA1c testing, which could benefit many people in Thailand.

Clinical trial registration:

https://www.thaiclinicaltrials.org, identifier [TCTR20230824003].
An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal
Authors: Frank Steven A.
Published: December 2023

How do cellular regulatory networks solve the challenges of life? This article presents computer software to study that question, focusing on how transcription factor networks transform internal and external inputs into cellular response outputs. The example challenge concerns maintaining a circadian rhythm of molecular concentrations. The system must buffer intrinsic stochastic fluctuations in molecular concentrations and entrain to an external circadian signal that appears and disappears randomly. The software optimizes a stochastic differential equation of transcription factor protein dynamics and the associated mRNAs that produce those transcription factors. The cellular network takes as inputs the concentrations of the transcription factors and produces as outputs the transcription rates of the mRNAs that make the transcription factors. An artificial neural network encodes the cellular input-output function, allowing efficient search for solutions to the complex stochastic challenge. Several good solutions are discovered, measured by the probability distribution for the tracking deviation between the stochastic cellular circadian trajectory and the deterministic external circadian pattern. The solutions differ significantly from each other, showing that overparameterized cellular networks may solve a given challenge in a variety of ways. The computation method provides a major advance in its ability to find transcription factor network dynamics that can solve environmental challenges. The article concludes by drawing an analogy between overparameterized cellular networks and the dense and deeply connected overparameterized artificial neural networks that have succeeded so well in deep learning. Understanding how overparameterized networks solve challenges may provide insight into the evolutionary design of cellular regulation.
Revised Heart Allocation Policy Improved Waitlist Mortality and Waiting Time With Maintained Outcomes in En-Bloc Heart-Lung Transplant Candidates and Recipients
Authors: Shudo Yasuhiro , He Hao , Elde Stefan , Woo Y. Joseph
Published: December 2023

The revised United Network for Organ Sharing heart allocation policy was implemented in October 2018. Using a national transplant database, this study evaluated the transplant rate, waitlist mortality, waiting time, and other outcomes of en-bloc heart-lung transplantation recipients. Adult patients registered on the national database for heart-lung transplants before and after the policy update were selected as cohorts. Baseline characteristics, transplant rates, waitlist mortality, waiting times, and other outcomes were compared between the two periods. In total, 370 patients were registered for heart-lung transplants during the pre- and post-periods. There were significantly higher transplant rates, shorter waitlist times, and substantially reduced waitlist mortality in the post-period. Registered patients waitlisted in the post-period had significantly higher utilization of intra-aortic balloon pumps, extracorporeal membrane oxygenation, and overall life support, including ventricular assist devices. Transplant recipients had significantly longer ischemic times, increased transport distances, and shorter waiting times before transplantation in the post-policy period. Transplant recipients held similar short-term survival before and after the policy change (log-rank test, p = 0.4357). Therefore, the revised policy significantly improved access to en-bloc heart-lung allografts compared with the prior policy, with better waitlist outcomes and similar post-transplant outcomes.
Optimal Time for Haymaking and Potential Production of Grass Hay on Soybean Overseeding in Brazilian Savanna
Authors: Fernandes Patrick Bezerra , Paim Tiago do Prado , Santos Luizmar Peixoto dos , Souza Brunna Rafaela , Leal Vanessa Nunes , Gonçalves Lucas Ferreira , Claudio Flávio Lopes , Santos Darliane de Castro , Guimarães Katia Cylene , Alves Estenio Moreira
Published: December 2023

The objective of this research was to determine the potential for hay production of Quenia guinea grass (Megathyrsus maximus cv. BRS Quenia), Congo grass (Urochloa ruziziensis), and Xaraes palisade grass (Urochloa brizantha cv. Xaraes) following soybean cultivation (Glycine max) in the Brazilian Cerrado. The experimental field was divided into 12 plots, with 4 replicates of each grass species. Chemical composition, forage mass (FM), and the potential for milk and carcass production were determined for the three grasses. Principal component analysis showed that the total digestible nutrients (TDN) had the most significant influence on milk and carcass potential. Quenia guinea grass reached maximum forage accumulation at 134 days after soybean harvest, representing 4191.51 kg ha−1 of FM. Congo grass and Xaraes palisade grass produced 4033.51 kg ha−1 and 4437.22 kg ha−1, respectively, in cuts made at 154 and 138 days. Quenia guinea grass had 20.71% soluble protein in its composition when harvested at 115 days. Regarding milk production potential, Congo grass, on the other hand, showed a linear reduction in milk production as the number of days after soybean harvest increased. As for carcass production potential, Congo grass demonstrated the highest carcass production potential (110.65 kg Mg−1 FM) at 107 cutting days. Xaraes palisade grass had the highest FM production, while Quenia guinea grass stood out in soluble protein. Conversely, Congo grass showed greater potential for hay production when overseeding in soybeans, as it excelled in carcass production potential. Therefore, for this grass, the ideal point for haymaking should occur within up to 107 days after sowing.
Sown Covers Enhance the Diversity and Abundance of Ground-Dwelling Predators in Mediterranean Pear Orchards
Authors: Perera-Fernández Luis Gabriel , de Pedro Luis , Sanchez Juan Antonio
Published: December 2023

Intensive agriculture has a strong impact on the structure of arthropod communities in soil. Sown covers can contribute to their conservation, especially for generalist predators such as spiders and predatory beetles. The aim of this research was to assess the effect of cover crop management on the abundance and diversity of ground-dwelling arthropods. For this purpose, a three-year experiment was conducted in a pear orchard that was divided into three blocks with two plots each: one with a sown cover of mixed plants from different families, including Boraginaceae, Asteraceae, Apiaceae, Brassicaceae, and Fabaceae, and the other with no cover, in which any spontaneous plants were periodically removed without using herbicides. The abundance of ground-dwelling arthropods was sampled using pitfall traps. The sown cover increased the overall richness of arthropods. Additionally, spiders from the families Lycosidae and Linyphiidae, as well as beetles from the families Carabidae and Staphylinidae, were more abundant in the sown cover. Conversely, detritivores such as collembolans and beetles from the family Tenebrionidae were less abundant in the cover. The abundance of ants was not affected by the type of cover. The sown cover increased the diversity of arthropods in the crop, as well as the abundance of generalist predators.
Changes in Nutrient-Regulated Soil Microbial Communities in Soils Concomitant with Grassland Restoration in the Alpine Mining Region of the Qilian Mountains
Authors: Yang Xiaomei , Feng Qi , Zhu Meng , Yang Linshan , Zhang Chengqi , Zhang Jutao , Wang Zhiyang , Feng Yonglin
Published: December 2023

In response to the significant ecological damage caused by unsustainable mining practices in the Qilian Mountains, ecological restoration projects have been undertaken in recent years. Analyzing the changes in soil microbial communities during the restoration process of mine meadows helps to reveal the mechanism of the restoration process in alpine mining areas. To explore the characteristics of soil microbial community distribution and their relationships with soil environmental factors during the restoration of alpine grasslands in the Qilian Mountains, we conducted surveys and analyses in two restoration levels low restoration (LR) and high restoration (HR) in the eastern Qilian Mountains, along with an undisturbed natural grassland control (NG). We found that as the degree of high-altitude mining area recovery increases, there were significant increases in vegetation cover, vegetation height, above-ground biomass, vegetation Shannon–Wiener index, soil organic carbon (SOC), soil water content (SWC), total nitrogen (TN), total phosphorus (TP), total potassium (TK), available phosphorus (AP), and available nitrogen (AN). Conversely, soil pH and electrical conductivity (EC) significantly decreased, with soil pH decreasing from 6.93 to 4.13. Restoration of high-altitude mining area grasslands significantly alters the distribution and composition of soil bacteria and fungi, while the impact on soil microbial community changes was not significant. Notably, with increasing recovery level, the dominant bacterial phyla are Acidobacteria and Proteobacteria, while the dominant fungal phyla are Ascomycota and Basidiomycota. These results indicate that changes in vegetation and soil properties both affect the composition of soil microbial communities, with soil properties having a greater influence. Soil fertility and nutrient levels emerge as the primary drivers influencing soil microbial composition communities and the degree of high-altitude mining area grassland recovery.
Combination with Annual Deworming Treatments Does Not Enhance the Effects of PCV2 Vaccination on the Development of TB in Wild Boar Populations
Authors: Galapero Javier , Ramos Alfonso , Benítez-Medina José Manuel , Martínez Remigio , García Alfredo , Hermoso de Mendoza Javier , Holgado-Martín Rocío , Risco David , Gómez Luis
Published: December 2023

Vaccination against PCV2 has been proven to be an effective measure to reduce the severity of TB in wild boar. The combination of this measure with strategies focused on treating other key concomitant pathogens, such as nematodes, could be a useful strategy. This study assesses whether a combination of deworming treatments and PCV2 vaccination may reduce the prevalence and severity of TB in wild boar. The study was conducted on five game estates in mid-western Spain where four groups of wild boar were produced: control, vaccinated, dewormed and vaccinated-dewormed. Wild boars from all groups were hunted between 2017 and 2020, and all of them received a TB diagnosis based on pathological and microbiological tests. Generalised linear models were used to explore the effect of deworming and PCV2 vaccination on TB prevalence and severity. PCV2-vaccinated animals showed lower probabilities of suffering severe TB lesions. However, no differences regarding TB severity were found between dewormed and non-dewormed wild boar. PCV2 vaccination reduces TB severity in wild boar. However, annual deworming does not produce a long-term parasitological reduction that can influence the development of TB in wild boar, nor does it improve the effect of PCV2 vaccination on TB.
Seasonal Activity of Adult Ticks Ixodes persulcatus (Acari, Ixodidae) in the North-West of the Distribution Area
Authors: Bugmyrin Sergey V. , Bespyatova Lyubov A.
Published: December 2023

The taiga tick Ixodes persulcatus (Schulze, 1930) (Acari, Ixodidae) is the main vector of the tick-borne encephalitis virus and one of the most widespread species of ixodid ticks in the Palaearctic. In this paper, we present long-term data on the seasonal activity of adult ticks in the north-west of their distribution. The seasonal activity of Ixodes persulcatus was studied from 1982 to 1990 and from 2012 to 2023 in the middle taiga subzone of Karelia (N62.0697, E33.961). In the study area, adult ticks I. persulcatus demonstrate a pronounced spring–summer activity with a unimodal curve of abundance change. A comparison of the monitoring data from the 1980s and the 2010s showed a significant increase in the abundance of I. persulcatus in the study area. A tendency towards an earlier start of the tick activity, as compared to the 1980s, is now being observed.
Modeling and Improvement for String-Based Drive Mechanism in Insect-like Flapping Wing Micro Air Vehicle
Authors: Ye Ruiqi , Liu Ziming , Cui Jin , Wang Chenyang , Wu Yirong
Published: December 2023

Most of the driving mechanisms used in micro flapping wing vehicles are gear and linkage transmission mechanisms, which convert the unidirectional rotation of the motor into the reciprocating flapping of the driving mechanism. However, gear and linkage transmission mechanisms occupy a larger space and weight with certain energy losses. This article introduces a drive mechanism that is different from gear and linkage mechanisms, namely the string-based mechanism. In this study, the working principle and various parameters in string-based mechanisms are analyzed, and the flapping trajectory and amplitude of the mechanism is simulated. Following that, this article proposes an improved method of the cam mechanism, designs the trajectory of a cam mechanism, and a physical design is carried out with a driving mechanism width of 22 mm. Subsequently, the experiments are conducted to compare the flapping trajectory of the actual mechanism with the simulation trajectory, thereby verifying the simulation accuracy. The results prove that, in a string-based mechanism, the ratio of the radius of the pulley to the installation radius of the double-layer bearings has a direct impact on the flapping amplitude, and optimizing the design of cam mechanisms can effectively reduce the tensile and relaxation phenomena in string-based mechanisms. The above conclusion was verified in physical experiments, where the modified cam mechanism effectively reduced the stuck phenomenon in the string-based mechanism.
An Improved Range-Searching Initial Orbit-Determination Method and Correlation of Optical Observations for Space Debris
Authors: Lei Xiangxu , Xia Shengfu , Liu Hongkang , Wang Xiaozhen , Li Zhenwei , Han Baomin , Sang Jizhang , Zhao You , Luo Hao
Published: December 2023

The Changchun Observatory of the National Astronomical Observatories, Chinese Academy of Sciences, and the Shanghai Astronomical Observatory are used to generate very short arc (VSA) angle observations of objects in low Earth orbit (LEO) and geostationary orbit (GEO) with their ground-based electrical–optical telescope arrays (EA), the Changchun EA and SAO FocusGEO, respectively. These observations are used in this paper. The range-searching (RS) algorithm for initial orbit determination (IOD) is improved through the multiple combinations of observations and the dynamic range-searching step length. Two different computation modes (the normal mode and the refining mode) of the IOD computation process are proposed. The geometrical method for the association is used. The IOD and association methods are extended to the real optical observations for both LEO and GEO objects. The results show that the IOD success rate of arcs from the LEO objects is about 91%, the error of the semimajor axis (SMA) of the initial orbital elements is less than 50 km, and the correlation accuracy rate is about 89%. The IOD success rate of arcs from the GEO objects is higher than 88%, and the correlation accuracy rate is greater than 87%. The recent COSMOS 1408 antisatellite test (ASAT) generated a large amount of debris. The algorithm of this paper and the observations of Changchun EA are used to initially identify new debris, possibly from the ASAT through initial orbit determination and track association. Finally, 64 suspected new pieces of debris can be found. The results show the effectiveness of the IOD and the correlation algorithm, as well as the potential application of the optical–electrical array in studying space events.
Seismic Performance Evaluation of Reinforced Concrete Buildings Retrofitted with a New Concrete Filled Tube Composite Strengthening System
Authors: Baek Ho-Jin , Jung Ju-Seong , Lee Kang-Seok , Lee Bok-Gi
Published: December 2023

This study proposes a concrete-filled tube composite strengthening system (CCSS), which is a new concept that can improve and supplement the vulnerability of existing CFT seismic strengthening methods. The CCSS seismic reinforcement method is easy to construct and integrates with the existing frame and reinforcement. It is one of the seismic strengthening methods that allows the simple calculation of the required amount of seismic reinforcement and can efficiently increase the strength when applied to existing reinforced concrete (R/C) buildings with non-seismic details dominated by shear failure. To examine the seismic safety of the proposed CCSS, two framework specimens were prepared based on an existing R/C building with non-seismic details. A pseudo-dynamic test was conducted on the unreinforced framework specimen and the framework specimen reinforced with CCSS to verify the seismic strengthening effect of applying CCSS to the existing R/C framework, i.e., in terms of the load–displacement characteristics and seismic response control capability. Based on the pseudo-dynamic test results, restoration of the force characteristics was proposed for the nonlinear dynamic analysis of the building reinforced with CCSS. Nonlinear dynamic analysis was conducted based on the proposed restoration of the force characteristics, and the results were compared with the pseudo-dynamic test results. Finally, for the commercialization of CCSS, nonlinear dynamic analysis was conducted on the existing whole R/C building with non-seismic details that was reinforced with CCSS. The seismic strengthening effect was then verified by examining the seismic response load, displacement characteristics, and the degree of seismic damage to the members based on the ductility ratio before and after seismic strengthening. The study results show that under a design basis earthquake with a magnitude of 200 cm/s2, the unreinforced R/C building exhibits shear failure, and light seismic damage is expected on the CCSS-reinforced building.
Fluorescence-Based Mono- and Multimodal Imaging for In Vivo Tracking of Mesenchymal Stem Cells
Authors: Yun Wan Su , Cho Hanhee , Jeon Seong Ik , Lim Dong-Kwon , Kim Kwangmeyung
Published: December 2023

The advancement of stem cell therapy has offered transformative therapeutic outcomes for a wide array of diseases over the past decades. Consequently, stem cell tracking has become significant in revealing the mechanisms of action and ensuring safe and effective treatments. Fluorescence stands out as a promising choice for stem cell tracking due to its myriad advantages, including high resolution, real-time monitoring, and multi-fluorescence detection. Furthermore, combining fluorescence with other tracking modalities—such as bioluminescence imaging (BLI), positron emission tomography (PET), photoacoustic (PA), computed tomography (CT), and magnetic resonance (MR)—can address the limitations of single fluorescence detection. This review initially introduces stem cell tracking using fluorescence imaging, detailing various labeling strategies such as green fluorescence protein (GFP) tagging, fluorescence dye labeling, and nanoparticle uptake. Subsequently, we present several combinations of strategies for efficient and precise detection.
Research on Teleoperated Virtual Reality Human–Robot Five-Dimensional Collaboration System
Authors: Zhang Qinglei , Liu Qinghao , Duan Jianguo , Qin Jiyun
Published: December 2023

In the realm of industrial robotics, there is a growing challenge in simplifying human–robot collaboration (HRC), particularly in complex settings. The demand for more intuitive teleoperation systems is on the rise. However, optimizing robot control interfaces and streamlining teleoperation remains a formidable task due to the need for operators to possess specialized knowledge and the limitations of traditional methods regarding operational space and time constraints. This study addresses these issues by introducing a virtual reality (VR) HRC system with five-dimensional capabilities. Key advantages of our approach include: (1) real-time observation of robot work, whereby operators can seamlessly monitor the robot’s real-time work environment and motion during teleoperation; (2) leveraging VR device capabilities, whereby the strengths of VR devices are harnessed to simplify robot motion control, significantly reducing the learning time for operators; and (3) adaptability across platforms and environments: our system effortlessly adapts to various platforms and working conditions, ensuring versatility across different terminals and scenarios. This system represents a significant advancement in addressing the challenges of HRC, offering improved teleoperation, simplified control, and enhanced accessibility, particularly for operators with limited prior exposure to robot operation. It elevates the overall HRC experience in complex scenarios.
A Novel Aptamer Biosensor Based on a Localized Surface Plasmon Resonance Sensing Chip for High-Sensitivity and Rapid Enrofloxacin Detection
Authors: Wang Pan , Ding Liyun , Zhang Yumei , Jiang Xingdong
Published: December 2023

Enrofloxacin, a fluoroquinolone widely used in animal husbandry, presents environmental and human health hazards due to its stability and incomplete hydrolysis leading to residue accumulation. To address this concern, a highly sensitive aptamer biosensor utilizing a localized surface plasmon resonance (LSPR) sensing chip and microfluidic technology was developed for rapid enrofloxacin residue detection. AuNPs were prepared by the seed method and the AuNPs-Apt complexes were immobilized on the chip by the sulfhydryl groups modified on the end of the aptamer. The properties and morphologies of the sensing chip and AuNPs-Apt complexes were characterized by Fourier transform infrared spectroscopy (FTIR), UV-Vis spectrophotometer, and scanning electron microscope (SEM), respectively. The sensing chip was able to detect enrofloxacin in the range of 0.01–100 ng/mL with good linearity, and the relationship between the response of the sensing chip and the concentration was Δλ (nm) = 1.288log ConENR (ng/mL) + 5.245 (R2 = 0.99), with the limit of detection being 0.001 ng/mL. The anti-interference, repeatability, and selectivity of this sensing chip were studied in detail. Compared with other sensors, this novel aptamer biosensor based on AuNPs-Apt complexes is expected to achieve simple, stable, and economical application in the field of enrofloxacin detection.
Understanding the Purchase Decisions of Silver Consumers in Short-Form Video Platforms from the Perspective of Existence, Relatedness, and Growth Needs
Authors: Yin Xicheng , Li Yicheng , Gao Rui , Li Jieqiong , Wang Hongwei
Published: December 2023

The differentiated characteristics of the silver (elderly) group from other groups means that the previous interaction mechanism in short-form video (SFV) e-commerce is no longer applicable. Drawing on sociotechnical systems theory and the ERG theory, this study is motivated to explore the purchase intention of silver consumers in SFV platforms. We categorize the characteristics of SFV platforms into social and technical aspects, and analyze silver consumers’ purchasing decisions in terms of existence, relatedness, and growth needs. The empirical results of 284 samples show that social belonging, perceived trust, and product relevance are positive factors that promote purchase. Information diversity and social interaction have significant positive effects on social belonging and perceived trust. Recommendation affordance is significantly positively associated with perceived trust and product relevance, while platform ease of use did not have a significant effect on perceived trust. The findings provide management insights into SFV platforms to better understand the digital divide faced by silver consumers and to facilitate increased consumption.
Peer-to-Peer Transactive Computation–Electricity Trading for Interconnected Virtual Power Plant Buildings
Authors: Gao Zhiping , Kang Wenwen , Chen Xinghua , Ding Sheng , Xu Wei , He Degang , Chen Wenhu , Xu Da
Published: December 2023

Advancements of the virtual power plant (VPP) concept have aggregated buildings as their power plants and/or service providers. This paper proposes a peer-to-peer transactive computation–electricity trading framework for multiple-building virtual power plants (BVPPs). In this framework, the interconnected BVPPs can proactively trade their available computation–electricity with each other. Multiple BVPP trading is an intractable optimization problem due to its strong computation–electricity decision-making couplings. Thus, the original problem is described as a game theoretic problem and resolved into the sequential subproblems of social computation–electricity allocation and payoff allocation. By considering the local decision-making of heterogeneous BVPPs, a fully distributed algorithm is further designed to optimize the trading problem by sharing only limited trading information. Finally, a three-BVPP system is used to verify the merits of system resource utilization and operational economy.
Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma
Authors: Garcia Natalia , Ulin Mara , Yang Qiwei , Ali Mohamed , Bosland Maarten C. , Zeng Weiqiao , Chen Liaohai , Al-Hendy Ayman
Published: December 2023

Leiomyosarcoma (LMS) has been challenging to diagnose because of limitations in clinical and radiographic predictors, as well as the lack of reliable serum or urinary biomarkers. Most uterine masses consist of benign leiomyoma (LM). However, it is currently a significant challenge in gynecology practice to differentiate LMS from LM. This inability poses grave consequences for patients, leading to a high number of unnecessary hysterectomies, infertility, and other major morbidities and possible mortalities. This study aimed to evaluate the use of Survivin-Sodium iodide symporter (Ad-Sur-NIS) as a reporter gene biomarker to differentiate malignant LMS from benign LM by using an F18-NaBF4 PET/CT scan. The PET/CT scan images showed a significantly increased radiotracer uptake and a decreased radiotracer decay attributable to the higher abundance of Ad-Sur-NIS in the LMS tumors compared to LM (p < 0.05). An excellent safety profile was observed, with no pathological or metabolic differences detected in Ad-Sur-NIS-treated animal versus the vehicle control. Ad-Sur-NIS as a PET scan reporter is a promising imaging biomarker that can differentiate uterine LMS from LM using F18-NaBF4 as a radiotracer. As a new diagnostic method, the F18 NaBF4 PET/CT scan can provide a much-needed tool in clinical practices to effectively triage women with suspicious uterine masses and avoid unnecessary invasive interventions.
CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF
Authors: Weidenhammer Annika , Prausmüller Suriya , Partsch Clemens , Spinka Georg , Luckerbauer Bianca , Larch Mirella , Arfsten Henrike , Abdel Mawgoud Ramy , Bartko Philipp E. , Goliasch Georg , Kastl Stefan , Hengstenberg Christian , Hülsmann Martin , Pavo Noemi
Published: December 2023

Background: CILP-1 regulates myocardial fibrotic response and remodeling and was reported to indicate right ventricular dysfunction (RVD) in pulmonary hypertension (PH) and heart failure (HF). This study examines CILP-1 as a potential biomarker for RVD and prognosis in heart failure with reduced ejection fraction (HFrEF) patients on guideline-directed medical therapy. Methods: CILP-1 levels were measured in 610 HFrEF patients from a prospective registry with biobanking (2016–2022). Correlations with echocardiographic and hemodynamic data and its association with RVD and prognosis were analyzed. Results: The median age was 62 years (Q1–Q3: 52–72), 77.7% of patients were male, and the median NT-proBNP was 1810 pg/mL (Q1–Q3: 712–3962). CILP-1 levels increased with HF severity, as indicated by NT-proBNP and NYHA class (p < 0.0001, for both). CILP-1 showed a weak–moderate direct association with increased left ventricular filling pressures and its sequalae, i.e., backward failure (LA diameter rs = 0.15, p = 0.001; sPAP rs = 0.28, p = 0.010; RVF rs = 0.218, p < 0.0001), but not with cardiac index (CI) and systemic vascular resistance (SVR). CILP-1 trended as a risk factor for all-cause mortality (crude HR for 500 pg/mL increase: 1.03 (95%CI: 1.00–1.06), p = 0.053) but lost significance when it was adjusted for NT-proBNP (adj. HR: 1.00 (95%CI: 1.00–1.00), p = 0.770). No association with cardiovascular hospitalization was observed. Conclusions: CILP-1 correlates with HFrEF severity and may indicate an elevated risk for all-cause mortality, though it is not independent from NT-proBNP. Increased CILP-1 is associated with backward failure and RVD rather than forward failure. Whether CILP-1 release in this context is based on elevated pulmonary pressures or is specific to RVD needs to be further investigated.
Molecules from Sargassum algae as Green Inhibitor for C38 in HCl Medium: Extraction, Characterization and Electrochemical Study
Authors: Lambert Prescilla , Said-Ahmed Mahado , Jama Charafeddine , Lebrini Mounim
Published: December 2023

The aim of this work is to develop new organic bio-sourced inhibitors that are ecofriendly and biodegradable. These natural inhibitors are organic, non-toxic molecules derived from plant extracts, containing numerous secondary metabolites, and are capable of being highly effective in protecting metals against corrosion. This study concerns the extraction, characterization and electrochemical study of natural organic compounds extracted from a species of Sargassum abundant on the coasts of Martinique, Sargassum fluitans III. The objective is to inhibit the corrosion of carbon steel. Electrochemical impedance spectroscopy (EIS) and linear polarization (LP) techniques have led to new experimental results showing inhibitor efficacy. The results obtained show that this plant extract could serve as an effective inhibitor for the C38 steel in acidic media. Studies on the phytochemicals of the crude extract were also carried out. Electrochemical studies, on each chemical families present, were also established to find the main constituents responsible for corrosion inhibition properties of the algae extract. The adsorption of Sargassum fluitans III extract on the C38 steel surface, obeys the Langmuir adsorption isotherm.
An Approach to the State Explosion Problem: SOPC Case Study
Authors: Zhou Shan , Wang Jinbo , Xue Panpan , Wang Xiangyang , Kong Lu
Published: December 2023

The system on a programmable chip (SOPC) architecture is better than traditional central processing unit (CPU) + field-programmable gate array (FPGA) architecture. It forms an efficient coupling between processor software and programmable logic through an on-chip high-speed bus. The SOPC architecture is resource-rich and highly customizable. At the same time, it combines low power consumption and high performance, making it popular in the field of high reliability and other new industrial fields. The SOPC architecture system is complex and integrates multiple forms of intellectual property (IP). Because of this, the traditional dynamic test and the static test cannot meet the requirements for test depth. To solve the problem of verification depth, we should introduce formal verification. But there are some types of IP forms that formal tools cannot recognize. These include black box IP, encrypted IP, and netlist IP in the SOPC model. Also, the state space explosion caused by the huge scale of the SOPC model cannot be formally verified. In this paper, we propose a modeling method using SOPC architecture. The model solves the problem of formal tools not recognizing multi-form IPs. To compress the state space, we propose reducing SOPC variables and branch relationships based on verification properties. Then, we conduct a property verification experiment on the reduced SOPC model. The experiment result shows that the model can significantly reduce the verification time.
Clarifying the Main Root Distribution of Trees in Varied Slope Environments Using Non-Destructive Root Detection
Authors: Taufiqurrachman Mochammad , Syafitri Utami Dyah , Rahman Mohamad Miftah , Siregar Iskandar Z. , Karlinasari Lina
Published: December 2023

Tree stability relies on the characteristics of both root and crown structures. However, studying root systems is challenging due to their underground location, often requiring destructive methods for assessment. Non-destructive approaches offer potential solutions, such as the root detector tool. However, research in this area remains limited and requires further development. This study aims to evaluate the root detector tool by inspecting the radial root distribution in trees with different tree crown shapes, both excurrent (Agathis loranthifolia) and decurrent (Samanea saman), which grow in various soil slopes and soil slope positions. In addition, we establish correlations between tree morphometry, the physical properties of soil, root attributes, sound wave velocity, and their relationship. Based on the results, it was found that the root detector tool is effective in evaluating root distribution, including identifying the main root. The slope position of the tree in a slope class influences the radial distribution of the main roots. This is related to the crown growth as indicated by the direction of its crown. Principal Component Analysis (PCA) findings suggest that parameter morphometric and soil and root properties data clustering align with slope position rather than slope class.
Single-Use Flexible Ureteroscopes: How Difficult Is It Today to Stay Up to Date? A Pictorial Review of Instruments Available in Europe in 2023
Authors: Vaccaro Chiara , Lorusso Vito , Palmisano Franco , Rosso Marco , Nicola Massimiliano , Granata Antonio Maria , Gregori Andrea , Talso Michele
Published: December 2023

The invention of the flexible ureteroscope (fURS) and its subsequent spread have revolutionized the surgical management of urolithiasis and upper tract urothelial carcinoma (UTUC). During the last few years, single-use flexible ureteroscopes (su-fURSs) have been developed to improve the limitations of reusable fURSs, namely their cost, durability and risk of device contamination. Since the introduction of the first fully disposable digital fURS, several su-fURSs have been developed by various manufacturers. In this pictorial review, we combined the different physical and technical features of su-fURSs currently available on the market with Food and Drug Administration (FDA) and European Conformity (CE) approval, in order to help surgeons choose the appropriate device according to each case requirement and personal preferences. To the best of our knowledge, 17 su-fURSs with CE and FDA approval have been developed to date.
Incidence of New-Onset Inflammatory Bowel Disease, Oral and Gastrointestinal Candidiasis, Herpes Zoster, Pulmonary Tuberculosis, and Major Cardiovascular Events in Patients with Moderate-to-Severe Psoriasis Exposed to Biologics
Authors: Kang Da-Hyun , Lew Bark-Lynn , Kwon Soon-Hyo
Published: December 2023

The multicenter, retrospective cohort study was aimed at examining adverse events in biologic-treated patients with moderate-to-severe psoriasis by using a real-world database. Thus, we analyzed exposure-adjusted incidence rates for new-onset inflammatory bowel disease (IBD), oral and gastrointestinal candidiasis, pulmonary tuberculosis, herpes zoster, and major cardiovascular events (MACEs) in biologic-treated patients with moderate-to-severe psoriasis. Overall, 2085 patients were found to have been exposed to tumor necrosis factor (TNF)-α, interleukin (IL)-12/23, IL-17, and IL-23 inhibitors (n = 463, 540, 635, and 447, respectively). No patient developed new-onset IBD. The incidence rates of oral and gastrointestinal candidiasis were comparable between patients treated with IL-23 and IL-17 inhibitors (5.6 and 5.3 per 1000 PY, respectively). None treated with IL-17 or IL-23 inhibitors reported pulmonary tuberculosis. The incidence rate of herpes zoster was the highest in patients treated with TNF-α inhibitors (17.0 per 1000 PY), followed by IL-17, IL-23, and IL-12/23 inhibitors (13.3, 7.8, and 2.7 per 1000 PY, respectively). MACEs were not reported in patients treated with IL-17 inhibitors but were reported in those treated with TNF-α, IL-23, and IL-12/23 inhibitors (incidence: 5.6, 3.8, and 1.8 per 1000 PY, respectively). The study indicated favorable safety profiles of biologics in Korean patients with moderate-to-severe psoriasis.
Predictive Performance of Neuron-Specific Enolase (NSE) for Survival after Resuscitation from Cardiac Arrest: A Systematic Review and Meta-Analysis
Authors: Kurek Krzysztof , Swieczkowski Damian , Pruc Michal , Tomaszewska Monika , Cubala Wieslaw Jerzy , Szarpak Lukasz
Published: December 2023

The prediction of outcomes following cardiac arrest continues to provide significant difficulties. A preferred strategy involves adopting a multimodal approach, which encompasses the careful evaluation of the biomarker neuron-specific enolase (NSE). This systematic review and meta-analysis aimed to gather and summarize new and existing evidence on the prediction effect of neuron-specific enolase for survival to hospital discharge among adult patients with cardiac arrest. We searched PubMed Central, Scopus, EMBASE databases, and the Cochrane Library without language restrictions from their inceptions until 30 October 2023 and checked the reference lists of the included studies. Pooled results were reported as standardized mean differences (SMDs) and were presented with corresponding 95% confidence intervals (CIs). The primary outcome was survival to hospital discharge (SHD). Eighty-six articles with 10,845 participants were included. NSE showed a notable degree of specificity in its ability to predict mortality as well as neurological status among individuals who experienced cardiac arrest (p < 0.05). This study demonstrates the ability to predict fatality rates and neurological outcomes, both during the time of admission and at various time intervals after cardiac arrest. The use of NSE in a multimodal neuroprognostication algorithm has promise in improving the accuracy of prognoses for persons who have undergone cardiac arrest.
A Modified Technique for Transcatheter Pulmonary Valve Implantation of SAPIEN 3 Valves in Large Right Ventricular Outflow Tract: A Matched Comparison Study
Authors: Houeijeh Ali , Karsenty Clément , Combes Nicolas , Batteux Clément , Lecerf Florence , Remy Frederic , Valdeolmillos Estibaliz , Petit Jérôme , Hascoet Sébastien
Published: December 2023

Introduction: Percutaneous pulmonary valve implantation (PPVI) with a SAPIEN 3 valve is effective for treating treat right ventricle outflow (RVOT) dysfunction. A modified technique was developed without prestenting using a protective valve delivery method. We aimed to compare the procedural results of the modified technique group (MTG) to those of patients in a conventional technique group (CTG). Methods: We designed a matched before–after study. All consecutive PPVI with SAPIEN 3 performed in the MTG over 9 months were matched, based on the RVOT type and size, to consecutive procedures performed previously with SAPIEN 3. Results: A total of 54 patients were included, equally distributed in the two groups. The sizes of the SAPIEN 3 valves were 23 mm (n = 9), 26 mm (n = 9), 29 mm (n = 36). The two groups were similar regarding demographic data, RVOT type, and pre-procedure hemodynamics. PPVI was performed in a single procedure in all patients of the MTG, whereas six (22.2%) patients of the CTG group underwent prestenting as a first step and valve implantation later (p = 0.02). The procedures were successful in all cases. Stent embolization was reported in two patients (7.4%) in the CTG, which were impacted in pulmonary arteries. In one case (3.7%), in the MTG, an unstable 29 mm SAPIEN 3 valve was stabilized with two stents and additional valve-in-valve implantation. The hemodynamics results were good in all cases, without significant differences between the two groups. The procedures’ durations and fluoroscopy times were significantly reduced in the MTG (48.1 versus 82.6 min, p < 0.0001; 15.2 versus 29.8 min, p = 0.0002). During follow-up, neither stent fracture nor valve dysfunction was noticed in either group. Conclusion: PPVI without prestenting and with a protective delivery method of the SAPIEN 3 valve significantly reduces the procedure’s complexity, the duration, and the irradiation while maintaining excellent hemodynamics results in selected cases.
Electromagnetic-Shocking-Induced Interface Healing and Mechanical Properties Improvement in Pre-Bonded Stainless Steel
Authors: Wu Min , Chen Jiancheng , Deng Jiadong , Wang Feng , Sun Qian
Published: December 2023

Hot-deformation pre-bonding is a newly developed method to avoid smelting defects in large stainless steel billets, in which the high-quality interfacial connection needs to be realized as a key guarantee. In this work, a novel electromagnetic shocking treatment (EST) method, as a special way to apply an external physical field, was proposed to introduce the hot-deformation pre-bonded austenitic stainless steel. It is demonstrated that EST can efficiently optimize the hot-deformation pre-bonded interface and restore the tensile properties of pre-bonded stainless steel within several seconds. The interface healing behaviors induced by EST were analyzed via the in situ observation of an optical micrograph, scanning electron micrograph, as well as electron backscattering diffraction. The optimization of the interface connection is mainly attributed to the fact that EST can act on the interface locally, leading to the healing of voids at the interface accompanied by a reduction in stress and the decomposition of oxide. In addition, EST plays another important role in adjusting the texture difference at both ends of the interface, which can further improve the mechanical properties. The results suggest that EST exhibits great potential in promoting the hot-deformation pre-bonding of large billets.