bluuebunny/crossref_metadata_2025 huggingface dataset:
THERAPEUTIC NUTRITION IN FOOD ALLERGY: NOT THAT SIMPLE
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Ishkova N.S. , Kaznacheeva L.F. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Kaznacheev K.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Geraschenko N.V. ,   Children's City Clinical Hospital No. 1, Novosibirsk, Russia
Published: July 2022

Purpose of the study. To assess the effectiveness of elimination diet therapy using therapeutic formulas in children with cow's milk protein allergy according to a 5-year follow-up. Materials and methods. A prospective, single-center, open, uncontrolled study was conducted. We observed 99 children with atopic dermatitis and allergy to cow's milk protein (CMP), the average age at the beginning of the study was 4.6 ± 0.8 months. The results of clinical observation, clinical assessment of the function of the digestive organs, and the level of the IgE to CMP were used as control methods. The selection of formulas for clinical nutrition at the stage of elimination diet therapy was carried out differentially, depending on the severity of the skin syndrome and gastrointestinal manifestations. The follow-up period was 5 years. Results. Food allergy manifested itself in 34 (34.3%) children only as a skin syndrome (atopic dermatitis), in 65 (65.7%) children as a skin syndrome in combination with gastrointestinal symptoms. In 67.7% of children, the use of therapeutic formulas based on highly hydrolyzed cow's milk protein and amino acids led to the normalization of the level of specific IgE. In mild atopic dermatitis, the average duration of the elimination period was 9.43 ± 2.7 months, in moderate atopic dermatitis, 19.3 ± 9.0 months, and in severe, 35.5 ± 14.8 months (p < 0.05). The number of patients with an exacerbation of an allergic disease with of the introduction of dairy products in mild, moderate and severe form of atopic dermatitis constituted 2 of 7, 6 of 48 (12.5%), 6 of 12 (50.0%) respectively (p < 0.05). Conclusion. In children with atopic dermatitis caused by food allergy to cow's milk proteins, the elimination diet in most cases (67.7%) leads to the normalization of the level of specific IgE, which makes it possible to start expanding the diet by introducing dairy products. The duration of the elimination period depends on the clinical manifestations of the allergic disease and the level of sensitization. When expanding the diet, patients should be provided with careful clinical and laboratory monitoring, including the determination of specific IgE to CMP. The high probability of persistent sensitization to CMP must be taken into account when prescribing elimination measures and drawing up rehabilitation programs for children with allergic diseases.
ASSESSMENT OF GLYCEMIA VARIABILITY IN PERSONS WITH TYPE 1 DIABETES MELLITUS USING THE GLINVA PROGRAM
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Dudina M.V. , Bondar I.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

High glycemia variability (GV) has a significant impact on the progression of complications in patients with diabetes mellitus (DM). In the course of research, using the GLINVA program based on the data of continuous glucose monitoring, an in-depth analysis of GV was carried out in 12 patients with type 1 diabetes mellitus who were on the insulin pump therapy and had compensation according to the level of glycated hemoglobin. It was found out that even with good diabetes compensation, the GV remains high enough, which can influence the development of complications. The use of variability indices in assessing the glycemic profile in patients with type 1 diabetes mellitus will help in correcting insulin therapy and timely prevention of complications.
CYTOKINE PROFILE OF ORAL FLUID IN PATIENTS WITH IRON DEFICIENCY ANEMIA
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Abramkina E.S. , Petrova T.G. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Pospelova T.I. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

The incidence of iron deficiency anemia (IDA) is increasing every year. IDA is characterized by a variety of clinical manifestations, including in the oral cavity, which is explained by a wide range of metabolic disorders. In patients with sideropenia, the body's resistance to infectious and inflammatory diseases decreases, which is associated with depression of humoral and cellular immunity. At the same time, data on the level of pro- and anti-inflammatory cytokines in patients with IDA are very contradictory; there is no clear understanding of the significance of changes in the oral cavity cytokine levels in this category of patients. The aim of the research was to study the content of pro- and anti-inflammatory cytokines in the oral fluid in patients with IDA. The study involved 168 patients. The main group included patients with IDA, the comparison group — patients with inflammatory periodontal diseases without somatic pathology, the control group — persons without concomitant diseases and inflammatory processes in the oral cavity. In all patients, the dental status was determined, as well as the content of IL-1β, IL-6, IL-4 and IFN-γ in the oral fluid. The results of dental examination showed the presence of inflammatory periodontal diseases in all examined with IDA. The combination of inflammatory periodontal diseases with IDA led to a significant decrease in the concentration of pro-inflammatory cytokines IL-1β and IL-6 in the oral fluid of the participants compared with similar indicators in patients with inflammatory periodontal diseases without somatic pathology, which indicates immune deficiency in these patients. The dental examination results showed the presence of inflammatory periodontal diseases in all examined with IDA. The combination of inflammatory periodontal diseases with IDA led to a significant decrease in the concentration of pro-inflammatory cytokines IL-1β and IL-6 in the oral fluid of the examined, compared with the similar indicators in patients with inflammatory periodontal diseases without somatic pathology, which indicates immune deficiency in these patients.
THE USE OF THE MEDICAL INFORMATION SYSTEM OF THE NOVOSIBIRSK REGION IN THE DOCUMENT FLOW OPTIMIZATION AND FORMATION OF PATIENT'S INTEGRATED ELECTRONIC MEDICAL CARD DURING LIFETIME PATHOANATOMICAL DIAGNOSTICS OF BIOLOGICAL MATERIAL
Authors:   City Clinical Hospital No. 1, Novosibirsk, Russia, Bravve Yu.I. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Velichkina N.N. ,   City Clinical Hospital No. 1, Novosibirsk, Russia, Odarchenko I.V. ,   City Clinical Hospital No. 1, Novosibirsk, Russia, Nadeev A.P. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Sokolov S.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Kvashnina E.A. ,   "Medical Information Analytical Center", Informatization Center, Novosibirsk, Russia, Isupova O.E. ,   "Medical Information Analytical Center", Informatization Center, Novosibirsk, Russia
Published: July 2022

Early diagnosis of malignant neoplasms is ensured by the quality, accessibility and continuity between medical institutions in the organization of the lifetime pathoanatomical diagnostics of biological material. Improving medical information systems with the involvement of the lifetime pathoanatomical diagnostics in the process of informatization of regional health care, developing mechanisms for documenting, storing and electronic exchange of personal medical information between medical institutions in the Novosibirsk region, is the main task of the system for organizing this type of diagnostics. The urgency of solving this problem is due to the shortage of personnel in the pathoanatomical services, the distance barriers between medical specialists and pathologist; need to ensure the formation of a created system for the exchange of medical documentation. The article presents the experience of using the functionality of the components of the Medical Information System of the Novosibirsk Region (MIS NR) in a regional state budgetary healthcare institution to form a unified information environment, integrate approved accounting forms and ensure efficient workflow in the course of lifetime pathoanatomical diagnostics. The aim of this research is to study the possibilities of additional functionality of the components of the MIS NR, implemented by the employees of the Center for Informatization of Medical Information Analytical Center, to identify the advantages of using the developed functions in optimizing the workflow during the lifetime pathoanatomical diagnostics of biopsy (operative) material, in the formation of a regional Integrated electronic medical record.
MORPHOFUNCTIONAL CHARACTERISTICS AND FEATURES OF SECONDARY DENTITION DEFORMITIES IN DIFFERENT AGE PERIODS
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Zheleznaya Yu.K. , Zhelezny S.P. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Piven E.D. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

Introduction. Currently, there is no consensus in the literature about the incidence of secondary deformities of the dentitions and their age characteristics. Thus, the question of the prevalence and features of secondary dentoalveolar deformities and anomalies of the dental arches in different age groups is relevant. Aim of the research. To study the prevalence, nature, features of secondary dentoalveolar deformities and anomalies of the dentition in different age groups. Materials and methods. For our study, we selected patients of different age groups who consulted the orthopedic dentistry clinic of the FSBEI HE Novosibirsk State Medical University of the Ministry of Health of Russia, as well as the 2–5 year students of the Faculty of Dentistry. Group 1 — 150 students aged 18–27 years, group 2 — 130 patients aged 30–45 years, group 3 — 140 patients aged 46–60 years. Results. In group 1, 150 second-fifth year students of the Faculty of Dentistry of the Novosibirsk State Medical University, aged 18–27 years, were examined. In 13 of them, the teeth were intact. Signs of secondary dentition deformities in patients of the first group were observed in 63 (42%) students. In group 2, 130 patients aged 30 to 45 years were examined, in 5 patients the dentitions were intact. Signs of secondary deformities of dentitions in the examined group 2 were observed in 71 (56%) patients. In group 3, 140 patients aged 46 to 60 years were examined, 18 of them had intact dentitions. In 122 of them, partial loss of teeth was observed. Signs of secondary deformities of the dentition in the examined group 3 were observed in 55 people (40%). Conclusion. The study shows that secondary dentition deformities can be observed both with preserved dentition in cases of multiple carious lesions of the occlusal surfaces of the teeth, anatomically incorrect restoration of the occlusal surfaces of the crowns of chewing teeth, or their contact surfaces after filling, and with partial loss of teeth in all age groups.
MEDICAL AND SOCIAL ASSESSMENT OF THE POPULATION IN THE NOVOSIBIRSK REGION: SOME INDICATORS, MODERN FEATURES
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Barkovskaya O.S. , Afanaseva G.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Novgorodtseva E.V. ,   Main Bureau of Medical and Social Assessment for the Novosibirsk Region, Novosibirsk, Russia
Published: July 2022

The purpose of this article was to study the organization of examination, features of the structure and dynamics of primary disability of the adult population in the Novosibirsk region, including in a pandemic. The article analyzes the number and contingent of disabled people in the Novosibirsk region, as well as compares the data with those of the Siberian Federal District and the Russian Federation as a whole. The materials for the study were reporting forms No. 7-Sobes of the FSI “Main Bureau of Medical and Social Expertise in the Novosibirsk Region”. It is shown that since 2010 the number of persons recognized as disabled for the first time has been steadily declining. The contingent of disabled people in the Novosibirsk region is mainly represented by disabled people of the 3rd group of retirement age. Over the period 2020–2021, the FSI “Main Bureau of Medical and Social Expertise for the Novosibirsk Region” of the Ministry of Labor of Russia conducted 30 examinations to determine the cause of death of medical workers performing work duties in the context of the COVID-19 pandemic. The period of restrictions caused by the new coronavirus infection emphasized the importance of electronic interdepartmental interaction between the institution of medical and social expertise and medical organizations, and became the reason for its active development.
Anti-inflammatory and analgesic activity of an inducible NO synthase inhibitor in an experiment
Authors:   Siberian State Medical University, Tomsk, Russia, Vengerovskii A.I. ,   Innovative Pharmacological Research, LLC, Tomsk, Russia, Bykova A.V. ,   Siberian State Medical University, Tomsk, Russia; Innovative Pharmacological Research, LLC, Tomsk, Russia, Bykov V.V. ,   Innovative Pharmacological Research, LLC, Tomsk, Russia, Motov V.S. ,   Siberian State Medical University, Tomsk, Russia
Published: July 2022

Introduction. Nitric oxide plays a key role in the development of inflammation. In this regard, it is promising to create a drug that reduces the production of nitric oxide in the focus of inflammation. Aim. To study experimentally the anti-inflammatory and analgesic effects of an inducible nitric oxide synthase inhibitor of an aminoguanidine derivative (LIS-M). Materials and methods. The compound LIS-M in 1% aqueous solution of polyvinylpyrrolidone was administered intramuscularly at doses of 5, 10 and 20 mg/kg to 150 male Sprague Dawley rats and 50 male CD-1 mice with experimental models of inflammation and pain. The animals of the comparison group received diclofenac at a dose of 10 mg/kg, the animals of the control group received 1% aqueous solution of polyvinylpyrrolidone in an equivalent volume. The effect of the LIS-M compound on the course of experimental pathology and its analgesic potential ulcerogenic effect were evaluated. Results. In male Sprague Dawley rats, the LIS-M compound reduces acute exudative inflammation caused by injection of carrageenan, histamine or serotonin in plantar aponeurosis, inhibits the proliferation of granulation tissue and exudation around a cotton swab implanted under the skin, does not have an ulcerogenic effect. In male CD-1 mice, it weakens the pain reaction and increases the time before it occurs. Conclusion. The LIS-M compound at doses ranging from of 5 to 20 mg/kg has a pronounced antiexudative, antiproliferative and analgesic effect, not inferior to the action of diclofenac at a dose of 10 mg/kg, and does not have an ulcerogenic effect.
Development of hydrophilic gel based on sulfated arabinogalactan
Authors:   A.E. Favorsky Irkutsk Institute of Chemistry, Irkutsk, Russia, Kostyro V.V. , Kostyro Ya.A. ,   A.E. Favorsky Irkutsk Institute of Chemistry, Irkutsk, Russia
Published: July 2022

Introduction. The modern pharmaceutical market offers a very limited range of medicines for the prevention and treatment of chronic venous insufficiency. The original pharmacologically active compound based on the potassium salt of the sulfated derivative of arabinogalactan (Agsular®) is an analog of heparin. Aim. Development of a hydrophilic gel based on Agsular®. Materials and methods. Model compositions were prepared according to traditional methods of gels preparation. The physical and chemical properties of the obtained samples were evaluated by methods of potentiometry, dynamic rheology and dynamic light scattering. The microbiological purity of the gels during storage was also evaluated. Results. The optimal composition of the hydrophilic gel containing Agsular® (1.5%) as the active substance is substantiated. This is a water-aerosil-glycerol-containing composition (the mixture ratio being 1:2:13 respectively). Studies of pH, dynamic viscosity and zeta potential confirm the stability of this gel. The introduction of a preservative (Nipagin 0.1%) ensures the microbiological purity of the gel during storage. Conclusion. The developed hydrophilic gel is a promising mean of prevention and treatment of chronic venous insufficiency.
The expression profile of a number of miRNAs in the placenta in timely and premature birth
Authors:   South Ural State Medical University, Chelyabinsk, Russia, Kazachkov E.L. , Semenov Yu.A. ,   South Ural State Medical University, Chelyabinsk, Russia, Veryaskina Yu.A. ,   Institute of Molecular and Cellular Biology, Novosibirsk, Russia, Kazachkova E.A. ,   South Ural State Medical University, Chelyabinsk, Russia, Chizhovskaya A.V. ,   South Ural State Medical University, Chelyabinsk, Russia
Published: July 2022

Introduction. Comparative analysis of the expression levels of a number of microRNAs (miRNAs) in placentas obtained during timely and spontaneous preterm birth (PB) will make it possible to identify those miRNAs that are involved in the genesis of spontaneous PB. MiRNAs characterized by aberrant expression in placental tissues may be promising biomarkers in the blood of pregnant women for assessing the risk of spontaneous PB. Aim. Comparative analysis of expression levels of a number of microRNAs in placental tissue in women in timely and premature birth. Materials and Methods. We performed an analysis of the expression level of a number of miRNAs in placental tissue from 30 patients with PB and perinatal losses (group 1), from 30 patients with PB without perinatal losses (group 2), from 30 maternity women with timely delivery (group 3). The expression levels of the following miRNAs were studied: 31, 100, 146, 150, 20a, 204, 221, 223, 1246, 128, let7a, 126, 451, 92a, 23a, 21, 125b, 26a, 29b, 191, and U6. For this, the material was deparaffinated step by step using mineral oil, then the RNA extraction, reverse transcription reaction, and real-time polymerase chain reaction were carried out. Results. It was found that in PB a statistically significant increase in the expression levels of miRNA-125b, miRNA-29b is observed in placental samples, and a decrease in the expression level of miRNA-451 in comparison with timely delivery placentas. In the PB with perinatal losses, a statistically significant decrease in the expression level of miRNA-150 was registered, and in the absence of perinatal losses, an increase in the expression level of miRNA-223 and miRNA-31 compared with placentas in timely delivery was revealed. In addition, in PB with perinatal losses compared to PB without perinatal losses, a statistically significantly lower level of expression of miRNA-221 and miRNA-223 is noted. Conclusion. Aberrant expression levels of miRNA-125b, miRNA-29b, and miRNA-451 in the placentas of patients with PB indicate their involvement in the pathogenesis of the latter, apparently due to dysregulation of angiogenesis, apoptosis, trophoblast invasion and glucose metabolism.
Technology for predicting the outcome of labor in the fetal occiput posterior presentation
Authors:   Chita State Medical Academy, Chita, Russia, Mudrov V.A. , Yakimova A.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

Introduction. Delivery in the fetal occiput posterior presentation is a subject of close attention of obstetricians and gynecologists. Despite the classification of this category of childbirth as physiological, the outcome directly depends on the transition of the occiput posterior position to the occiput anterior one during labor. Persistence of the posterior position is a risk factor for operative delivery. Aim. Development of a technology for predicting the outcome of labor in the fetal occiput posterior presentation. Materials and Methods. A prospective analysis of 118 cases of childbirth in the period 2018–2021 was carried out at the Perinatal Center of the Regional Clinical Hospital, Chita. The total sample was divided into 3 groups: group 1 included 80 parturient women with the fetal occiput anterior presentation; group 2 included 18 patients with the fetal occiput posterior presentation, during the delivery of which there was a turn into the anterior position; group 3 included 20 parturient women with the fetal occiput posterior presentation, during the delivery of which a turn to the anterior position did not occur. The groups were comparable in age and extragenital pathology. All women underwent physical and ultrasound examination 1–2 days ahead of the delivery. Results. The technology for predicting the outcome of labor in the fetal occiput posterior presentation is implemented on the basis of a multilayer perceptron, the rate of incorrect predictions in the learning process of which was 11.1%. The structure of the trainable neural network included 8 input neurons: parity of childbirth, height, body weight and distantia spinarum of a woman, biparietal diameter and femur length of a fetus, presence or absence of pre-induction of labor. Conclusion. An integrated approach based on neural network analysis of the history, as well as data of physical and ultrasound examinations, makes it possible to predict the outcome of labor with an accuracy of up to 90.0% in the fetal occiput posterior presentation. The use of this technology in clinical practice will reduce the incidence of adverse obstetric and perinatal outcomes in the fetal occiput posterior presentation.
Development of a technique for amphotericin B determination by spectrophotometric method in biological fluids
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Pashkova L.V. , Ivanovskaya E.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Ligostaev A.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

Introduction. The development of methods for determining the concentration of antimicrobial drugs used in various pathological conditions of the body is of great interest. Aim. Development of a technique for quantitative determination of amphotericin B in blood serum. Materials and methods. The drug amphotericin B was used for the preparation of solutions. The optical density of the solutions was determined by the spectrophotometric method. Results. The method of quantitative determination of amphotericin B in sodium chloride solution, which is the closest in composition to biological fluids, has been tested. Statistical analysis showed that the error of the method for determining the concentration of amphotericin B does not exceed 10%. Conclusion. A unified method of spectrophotometric determination of amphotericin B in blood serum has been developed. The optimal conditions for the determination of amphotericin in biological fluids were found: the solvent – 0.9% sodium chloride solution, wavelengths – 363, 383 and 406 nm, t – 3–6°C, detectable concentrations – from 1.0 · 10–2 to 1.0 · 10–5 mg/l.
Development of a granulate based on amidines with anti-inflammatory activity
Authors:   Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia, Mar’yushkina V.S. , Abrosimova O.N. ,   Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia, Kuvaeva E.V. ,   Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia, Ladutko Yu.M. ,   Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia
Published: July 2022

Introduction. Amidines have a fairly high biological activity. One aspect of their therapeutic action is the anti-inflammatory effect. Therefore, the development of a granulate technology based on amidines with anti-inflammatory activity for subsequent dosing into enteric capsules is an issue of interest today. Aim. To develop a granulate based on amidines with anti-inflammatory activity for subsequent dosing into enteric capsules. Materials and methods. An experimentally synthesized substance N-(naphthalene-2-yl)benzene carboximid¬amide and excipients: lactose monohydrate, sodium starch glycolate (Explotab®), povidone (Plasdone™ K-29/32) were used as the active substance. The granulate was obtained by pressing wet masses through. The resulting granulate was dosed into enteric capsules. The technological properties of the substance and the quality attributes of the granulate and capsules were determined according to the methods described in the State Pharmacopoeia of the Russian Federation, edition XIV (SP XIV). Results. According to the results of the study of technological properties, it was found that the substance has poor flowability, is quite light and bulky, the main fraction of the powder is particles up to 0.1 mm in size. To improve the flowability and reduce the hygroscopicity of the granulated material, lactose monohydrate was used as a filler. A 5% solution of Plasdone K-29/32 was chosen as a binder, which improves the dissolution and bioavailability of drugs due to the formation of water-soluble complexes. Sodium starch glycolate was used as a disintegrant. The resulting granulate was dosed into enteric capsules that meet the SP XIV requirements. Conclusion. A synthesis method was proposed and a substance of N-(naphthalene-2-yl)benzene carboximidamide with pharmacological activity was synthesized. Excipients were selected taking into account the properties of the substance, composition and technology of the granulate based on the previously synthesized substance N-(naphthalene-2-yl)benzene carboximidamide was developed, followed by dosing into enteric capsules, a draft specification for enteric capsules was proposed in accordance with the SP XIV requirements.
Somatotype features of autonomic regulation in adolescent girls in Krasnoyarsk
Authors:   Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia, Levchenko Yu.S. , Nickel V.V. ,   Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia, Efremova V.P. ,   Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia
Published: July 2022

Introduction. The decrease in physical health parameters of children and adolescents in our country justifies the need to develop programs aimed at correcting this situation, in particular, conducting research in the field of anthropology, studying the autonomic balance and the influence of the body’s individual morphological features on it. Aim. Identification of the relationship between autonomic status and morphofunctional parameters of the cardiovascular system depending on the somatotype in adolescent girls of the city of Krasnoyarsk. Materials and methods. The study involved 158 adolescent girls (from 13 to 15 years old) living in Krasnoyarsk. An anthropometric examination was carried out with the further determination of the somatotype according to the Rees-Eysenck body index. Some indicators of the cardiovascular system (systolic and diastolic blood pressure (SBP and DBP), heart rate (HR)) and the tone of the autonomic nervous system were assessed according to the Kerdo’s index. Results. According to the results of anthropometry, the participants were distributed as follows: ectomorphy – 65 people, mesomorphy – 51 people, endomorphy – 42 people. A statistically significant increase in SBP and DBP was found as body strength increased in all three groups. In ectomorphic body type girls, there was a decrease in SBP values in combination with higher HR. The predominance of sympathicotonia was found in the ectomorphy and endomorphy groups (65.2 and 52.8%, respectively). The largest number of girls with the excitation-inhibition balance of the autonomic nervous system was among mesomorphy (53.3%) and slightly less among endomophy girls (39.6%), both of these indicators were significantly higher than among the ectomorphic body type girls (30.4%). At the same time, in the latter, the parasympathicotonia predominates less often (4.3%) than in mesomorphy (6.7%) and endomorphy (7.5%) (p < 0.05). Conclusion. The obtained data on the difference in hemodynamic parameters and autonomic status in girls aged 13–15, depending on the body type, must be considered when choosing sports activities and realization of medical and preventive work in a secondary school.
Contribution to the knowledge of planthoppers and leafhoppers fauna (Hemiptera: Fulgoromorpha et Cicadomorpha) of the Bieszczady Mountains (south-eastern Poland)
Authors: Stroiński Adam , Błaszczyk Jakub , Świerczewski Dariusz
Published: July 2022

The paper provides new distributional data for 5 planthopper and 61 leafhopper species, recorded from the Bieszczady Mountains (south-eastern Poland), including 35 taxa listed as new for the region.
Critical check-list of spiders (Araneae) of the Kampinos National Park
Authors: Rozwałka Robert
Published: July 2022

This paper presents the results of the research conducted so far on Araneae of the Kampinos National Park. After verification of the published data, it was established that 305 species of spiders recorded in the Park area; this is 36.8% of Araneae reported from Poland. The results of the study so far indicate that Kampinos NP is characterized by a very great diversity of araneofauna. In the Park have been found four protected species: Agroeca dentigera, Eresus kollari, Philaeus chrysops, Yllenus arenarius and many rare and interesting spider species, e.g. Archaeodictyna ammophila, Enoplognatha mordax, Haplodrassus moderatus, Kishidaia conspicua, Titanoeca spominima and many others. Three species: Micaria micans, Pardosa alacris and Sibianor larae are reported for first time from this park.
Atheta (Dimetrota) knabli G. Benick, 1938 (Coleoptera: Staphylinidae) – a new species for the Polish fauna
Authors: Walesiak Michał , Komosiński Karol , Feldmann Benedikt , Thorn Simon
Published: July 2022

In 2021, two specimens of Atheta knabli, a rare beetle species known mostly from subalpine/alpine regions in Europe, were discovered with dung-baited traps in a lowland habitat of Białowieża Forest, NE Poland. To our knowledge, this is the first record of this species for Poland and the first confirmed for a lowland habitat.
Uma alternativa didática ao ensino de inequações exponenciais
Authors:   Universidade do Estado do Pará, Pantoja Cleidivaldo Corrêa , Alves Fábio José da Costa
Published: July 2022

A sequência de atividades para o ensino de Inequação Exponencial foi construída no âmbito do Programa de Pós-graduação em Ensino de Matemática da Universidade do Estado do Pará, como produto de uma pesquisa dissertação de mestrado. Este produto educacional é destinado para professores e estudantes do Ensino Médio para ensino e aprendizagem de Inequação Exponencial. Trata-se de um produto didático validado experimentalmente que apresentou potencialidades quantitativas e qualitativas para o objetivo a que se destina: ensinar Inequação Exponencial por meio da instrumentação do recurso Geogebra e promovendo o registro de representações do objeto matemático Inequação Exponencial.
Educational Game Introduction and Understanding of the Basic Values of the Republic of Indonesia for Android-Based Elementary School
Authors: Subarjo Abdul Haris , Retnowati Nurcahyani Dewi , Al Afiah Yanti Alif Al Afiah Alif
Published: July 2022

This research creates an android-based educational game for the basic values of the Unitary State of the Republic of Indonesia. Making educational games using Game Maker in making the application, besides that this game is also equipped with drawings made with sketches and edited using CorelDraw to add color and complete the images that will be included in the educational game. The results of the feasibility test on the children of SD Khalifah, the level of eligibility for educational games, showed a percentage of 86.28% of 50 respondents. The game, which is intended for elementary school students, is expected to explain the practice of the country's basic values more pleasantly.
Unconstitutional Legislative Omission and the Status of the Autonomous Republic of Abkhazia
Authors: Goradze George
Published: July 2022

The article deals with a legal problem such as a legal gap, in particular unconstitutional legislative omission. Georgian legislation does not recognize unconstitutional legislative omission, although examples of such shortcomings can be found here. This article focuses on the Article 7(3) of the Constitution of Georgia, which requires the adoption of a constitutional law on the Autonomous Republic of Abkhazia, although this requirement has not been fulfilled for almost twenty years. The article shows the large vacuum related to the constitutional regulation of the Autonomous Republic of Abkhazia, and negative consequences related to it. The article also reviews the approach of several countries to unconstitutional legislative omission and expresses an opinion on resolving this problem in the Georgian reality.
Do You Like Dancing Robots? AI Can Tell You Why
Authors: De Filippo Allegra , Mello Paola , Milano Michela
Published: July 2022

Humanoid robots have been successfully used in artistic research areas, and many works have studied and implemented systems for robotic dance. However, only few works take into account the human evaluation of these artistic outputs. This work makes a step in the direction of addressing the complex task of defining criteria for the evaluation of robotic dance performances. For this aim, in the context of a Master course on Fundamentals of Artificial Intelligence (AI), we have organized a challenge among our students and the winner is decided on the basis of a questionnaire we defined for robotic dance evaluation. In addition, we created a public dataset that maps the features of each choreography to the judgements provided by audience with different backgrounds on several evaluation targets. Then, we tested various Machine Learning models for predicting the audience evaluation, and we propose a choreography features importance analysis to help both human choreographers and AI algorithms to create dance performances with a major impact on the audience. We also suggest new directions for future interdisciplinary research.
Lessons learned from the COVID-19 pandemic: Improving initial investigations with the implementation of a COVID-19 blood request panel
Authors: Jegatheeswaran Lavandan , Choi Byung , Cohn Martin , Minocha Amal , Mutengesa Ernest , Zala Ashik , Alhilani Michel
Published: July 2022

BACKGROUND:

During the COVID-19 pandemic, the Hillingdon Hospitals NHS Foundation Trust produced trust guidelines for the initial blood investigation of COVID-19 inpatients. However, insufficient education meant inconsistent adherence to this guidance.

OBJECTIVE:

To examine whether the implementation of a COVID-19 blood request panel improves adherence to local trust guidelines.

METHOD:

Between March and April 2020, initial blood investigations performed for positive COVID-19 cases were compared to guidelines. Results were presented locally and a COVID-19 panel was added to the electronic system that provided prompts for appropriate investigations. A re-audit between May and June 2020 was conducted to assess adherence post-intervention.

RESULTS:

383 patients were identified in the initial audit cohort and a sample of 20 patients were re-audited. Adherence to Full Blood Count, Urea and Electrolytes, C-reactive Protein and Liver Function Tests increased to 100% from 99.7% ( p = 0.8), 99.2% ( p = 0.69), 98.7% ( p = 0.61), and 96.6% ( p = 0.4) respectively. Coagulation screen adherence increased to 90% from 72.8% ( p = 0.09). Appropriate requesting of D dimers increased to 50% from 19.9% ( p = 0.001). Inappropriate troponin requesting decreased to 26.3% from 38.9% ( p = 0.23).

CONCLUSION:

A user-friendly COVID-19 panel of investigations resulted in improved adherence to guidelines. Clear communication and education are essential to help alleviate uncertainty during a pandemic.
Improving Students’ Creative Thinking In Learning Arabic Through HOTS Based Project Based Learning Model
Authors: Susanto Susanto , Desrani Ayu , Ritonga Apri Wardana , Rubiyantoro Yohan
Published: July 2022

This study aims to analyze students' creative thinking skills in learning Arabic through the application of a project-based learning model based on Hots. This study uses a quantitative approach with experimental methods of the type of quasi-experimental research with the research design used is Post-Test Only Control Group Design. The population in this study were students of class X MAN 1 Malang City, East Java, Indonesia. The data collection instrument used was a test using an independent sample t-test analysis test. Based on the independent sample t-test, the significance value of the variable analysis was 0.013 < 0.05 with an average value of 75.12 for the experimental class and 70.28 for the control class. Through the results obtained, there is a significant positive effect between experimental class students who use project-based learning models and control class students who only use conventional models. So to improve students' creative thinking skills, they can use project-based learning in Arabic learning.
Creative Arabic Learning Based On Quizizz: Model And Impact
Authors: A'yuni Qurrotul , Hilmi Danial , Benedik Salma Laksmita , Ahmed Bakri Mohamed Bkheet
Published: July 2022

Since entering the Covid pandemic, learning has been shifted simultaneously to an online or blended learning mode. Teachers need alternative creative learning based on media and digital- guides, including Arabic language teachers. The article aims to describe the creative learning model using Quizizz and its impact. For this reason, descriptive qualitative type of field study is used as research method. The results are; 1) After the teacher is able to design a creative Arabic learning model from planning, implementation, and assessment, it shows that the teacher can analyze students needs, able to be creative, active, and fun, and also the teacher has good professionalism; 2) Quizizz has a positive impact on students and their grades and learning performance.
Ta’alum Al-Lughah Al-Arabiyyah Li Aghradl Khashah: Akadimi Wa Mihni
Authors: Rahmi Novita , Sarbaini Albarra , Sutarjo J. , Wulandari Nawang
Published: July 2022

Arabic has a function and essence for the life of Islamic communication, but because of its nature which is in the midst of an ongoing educational tradition today, it requires various innovations, as a logical consequence of the development of science and technology. The development of science and technology is so rapid for human life, it is necessary to make efforts on Arabic language teaching technicians who adapt to their respective fields and competencies. Then the purpose of learning Arabic with this specific purpose is to develop the professional abilities and academic potential of students.This type of research is descriptive qualitative research, namely a research conducted systematically by using library data using data collection tools, namely, observation, and documentation. This study provides a goal-based Arabic learning model to be achieved which is called Arabic learning for special purposes. This learning is more directed at learning Arabic for a certain scope and context, for example for work or professions and also in the academic field.
Engineering preparation of the territory in conditions of laying soft soil
Authors: Malyshev Oleg , Rashchenko Andrii , Dyptan Tetiana
Published: July 2022

At present, in large cities, cities - millionaires, there is a tendency to build a large volume of residential multi-storey buildings entertainment complexes on undeveloped, free from construction areas of urban territory. Large cities and settlements are expanding due to the development of areas for buildings. The geological structure of this areas is difficult. In particular, the complexity is due not only to low values of physical and mechanical characteristics of soils, but also to special properties (high compressibility, decay of organic residues, unevenness and duration of sedimentation over time, etc.) [1, 5]. A certain part of the territory of our country is represented by peat soils, which to some extent can be considered as minerals, the use of which as a basis for buildings and structures is not rational and requires the use of special measures and construction works. When designing buildings and structures in such engineering and geological conditions, it is necessary to take into account that all types of geotechnical actions on the part of the deformed base on the building are reduced mainly to uneven vertical and horizontal deformations of the base surface. In order to ensure reliable operation of the building in such engineering geological conditions, it is necessary to make structural and technological decisions that will comprehensively take into account the complexity of the site and allow to implement the design solution. At the same time, practice of design and construction shows, quite often the listed unfavorable factors and dangerous processes are ignored, not taken into account or incorrect decisions are made to ensure the reliability of the basis.To solve this problem, the following tasks are relevant: a set of modern modeling tools (numerical calculation) and field observations, which allow you to analyze the results and take a reasonably correct (reliable, cost-effective) version of the base preparation for  buildings or structures [2] to ensure reliable and safe operation of the building or structure.
Comparative assessment of the slope stability using different calculation methods
Authors: Nosenko Viktor , Skochko Liudmyla , Malaman Artur
Published: July 2022

Comparison of the results of assessment of the of slope stability to determine the feasibility of construction of retaining structures is presented in this paper

The construction of a grain terminal on a landslide slope in the Odessa region was selected as the object of researching. The building area belongs to the Black Sea basin region and is located on the southwestern slope of the Ukrainian Crystal Shield. The uneven stepped surface of the crystalline basement consists of blocks. Despite the significant irregularities of the crystalline basement, they are reflected in the relief through the sedimentary cover. To ensure of the slope stability, it is planned to install a cascade of retaining structures. There are pile retaining walls.

The calculations are based on the analysis of the stress-strain state of the slope and anti-landslide structures using two fundamentally different methods. These methods of calculation using modern software:

- analytical method for assessing the slope stability (limit equilibrium method);

- assessment of the slope stability by the method of numerical modeling of the stress-strain state of the elements of the system "soil mass - anti-landslide structures".

Calculations were made for two calculated cross-sections and for different stages of construction. There are stages native state, during construction and exploitation. 1st stage is assessment of the slope stability in its natural state, before building beginning. 2nd stage is assessment of the slope stability during the construction of the 1st retaining wall and excavations of the first level of the pit; stage 3 - assessment of slope stability after construction of anti-landslide structures and excavations of the pit. Stage 4 - assessment of the slope stability at the stage of grain terminal exploitation, it is meaning the construction of foundation structures.

According to the results of calculations, the slope stability safety factors were determined, the analysis of SSS elements of the system "soil mass - landslide structures" was carried out and the reinforcement of retaining walls was selected.
Nogueira Pecã: identificação e manejo de doenças
Authors: Poletto Tales , F. Brião Muniz Marlove , Poletto Igor , M. Stefenon Valdir
Published: July 2022

Este livro apresenta uma compilação das principais doenças da nogueira-pecã diagnosticadas no Sul do Brasil, identificadas por pesquisadores do Laboratório de Fitopatologia Elocy Minussi da Universidade Federal de Santa Maria e do Laboratório de Controle Biológico e Proteção de Plantas da Universidade Federal do Pampa, Campus São Gabriel, os quais são pioneiros nos estudos científicos com a cultura no Brasil. Com esta publicação espera-se fornecer subsídios a produtores, técnicos, estudantes, professores, pesquisadores e ao público geral, para a realização da correta identificação das doenças e o manejo dos pomares de nogueira-pecã com maior segurança, sustentabilidade e eficiência, contribuindo para o desenvolvimento da pecanicultura brasileira.
Clínica fonoaudiológica de linguagem com crianças pequenas e seus familiares
Authors: Ramos de Souza Ana Paula
Published: July 2022

Esta obra aborda o percurso teórico-prático de uma fonoaudióloga em sua clínica com crianças pequenas e seus familiares, que remonta o período de sua formação profissional na graduação realizada na Universidade Federal de Santa Maria, sua atuação clínica privada entre 1987 e 2006, e sua atividade de extensão e pesquisa com alunos da graduação e dos programas de pós-graduação em Distúrbios da Comunicação Humana no projeto Clínica interdisciplinar de bebês realizado na Universidade Federal de Santa Maria entre 2007 e 2018. Essa clínica é apresentada por meio do estudo de casos clínicos de modo ensaístico, buscando conectar como esses casos foram pensados à luz da teoria de linguagem presente na formação da autora e a reflexão que eles trouxeram de modo a impulsionar a busca de novas teorias. Deste modo a autora introduz ao fonoaudiólogo, em formação, a teoria gerativista, a proposta interacionista na perspectiva brasileira de Cláudia de Lemos e a visão enunciativa de linguagem ancorada em deslocamentos da teoria benvenisteana para a clínica fonoaudiológica. Embora não seja o foco principal do livro, a autora traz algumas reflexões sobre a interface entre psicanálise e clínica fonoaudiológica de linguagem com crianças pequenas e seus familiares.
ÍNDICE SPAD COMO ESTIMATIVA INDIRETA DO CONTEÚDO DE CLOROFILA EM PLANTAS DE QUIABO
Authors: Villa e Vila Vinicius , Soares Wenneck Gustavo , De Souza Terassi Daniele , Rezende Roberto , Saath Reni
Published: July 2022

A clorofila, molécula responsável pela atividade fotossintética das plantas, pode ser quantificada por métodos diretos e indiretos. O objetivo do estudo foi relacionar os resultados do conteúdo de clorofila obtidos por diferentes métodos de determinação em folhas de quiabo. Foi estimado o conteúdo de clorofila através do índice SPAD (não-destrutivo) e da extração dos pigmentos foliares com acetona (destrutivo). As análises foram realizadas em folhas de quiabo (cultivar Santa Cruz 47) do terço médio de plantas no estágio reprodutivo com coloração variando de amarela a verde escuro, em condição de sequeiro. Determinações pelo método não destrutivo foram realizadas com equipamento SPAD-502 e as determinações por método destrutivo foram realizadas por espectrometria, utilizando acetona como extrator. Foi realizada análise descritiva, correlação e regressão nos dados. O índice SPAD variou de 20,93 a 49,03, e apresentou correlação linear com o conteúdo de pigmentos foliares. O índice SPAD apresentou correlação positiva com os teores de clorofila b e clorofila total, entretanto para o conteúdo de clorofila a foi observado relação negativa. A variação do conteúdo de carotenoides não apresentou relação direta com o índice SPAD. A estimativa do conteúdo de clorofila por método não destrutivo apresenta relação direta com o conteúdo absoluto em folhas de quiabo.