bluuebunny/crossref_metadata_2025 huggingface dataset:
INTERLEUKIN-17INHIBITION WITH SECUKINUMAB IMPROVES SUDOMOTOR DYSFUNCTION IN PSORIATIC ARTHRITIS
Authors: Syngle Ashit , Verma Inderjeet , Kaur Sudeep , Syngle Tanya
Published: March 2018

Psoriatic arthritis (PsA) is a relapsing inflammatory disease, most commonly a seronegative oligoarthritis found in patients with psoriasis, characterized by the absence of rheumatoid factor in serum, with differentiating features of distal joint involvement and in extreme cases of arthritis mutilans (which is a destructive form of PsA). Cardiovascular autonomic and peripheral sympathetic neuropathy occurs in PsA. However, there is no specific treatment recommendation for autonomic neuropathy (AN) in psoriatic diseases. Secukinumab, a recently approved therapeutic advancement for psoriasis and psoriatic arthritis, is an immunoglobulin G (IgG) 1k fully monoclonal antibody that selectively inhibits the effector function of interleukin (IL)-17A. Its effect on sudomotor dysfunction in PsA has not yet been reported. This is the first reported observation of improvement in peripheral sympathetic autonomic neuropathy with secukinumab in PsA. We report a case of a 52-year-old male with PsA on methotrexate 15 mg/week with severe disease activity treated with the addition of subcutaneous secukinumab 150 mg once a week for 5 w followed by once a month dose. We found significant improvement in sudomotor dysfunction after 4 and 8 w of treatment.
STRUCTURAL EXPLORATION AND PHARMACOPHORIC INVESTIGATION OF PYRAZOLE BASED ANALOGS AS NOVEL HISTONE DEACETYLASE 1 INHIBITOR USING COMBINATORIAL STUDIES
Authors: Singh Avineesh , Rajak Harish
Published: March 2018

Objective: Histone deacetylase inhibitors (HDACi) have four essential pharmacophores as cap group, connecting unit, a linker moiety and zinc binding group for their anticancer and histone deacetylase (HDAC) inhibition activity. On the basis of this fact, the objective of this research was to evaluate the exact role of pyrazole nucleus as connecting unit and its role in the development of newer HDACi.Methods: Ligand and structure-based computer-aided drug design strategies such as pharmacophore and atom based 3D QSAR modelling, molecular docking and energetic based pharmacophore mapping have been frequently applied to design newer analogs in a precise manner. Herein, we have applied these combinatorial approaches to develop the structure-activity correlation among novel pyrazole-based derivatives.Results: the Pharmacophore-based 3D-QSAR model was developed employing Phase module and e-pharmacophore on compound 1. This 3D-QSAR model provides fruitful information regarding favourable and unfavourable substitution on pyrazole-based analogs for HDAC1 inhibition activity. Molecular docking studies indicated that all the pyrazole derivatives bind with HDAC1 proteins and showed critical hydrophobic interaction with 5ICN and 4BKX HDAC1 proteins.Conclusion: The outcome of the present research work clearly indicated that pyrazole nucleus added an essential hydrophobic feature in cap group and could be employed to design the ligand molecules more accurately.
EVALUATION OF ANTI-ARTHRITIC POTENTIAL OF PARTITIONED EXTRACTS OF BOUGAINVILLEA X BUTTIANA (VAR. ROSE) HOLTTUM AND STANDL
Authors: Vargas Rodolfo Abarca , Guerrero Rigoberto Villanueva , Petricevich Vera L.
Published: March 2018

Objective: Bougainvillea is a natural source with potential for clinical use, and this plant is routinely employed in traditional Medicine in Mexico. This study planned to evaluate the effect of ethanolic extract partitioned of Bougainvillea x buttiana on acute and chronic inflammation.Methods: The extract from Bougainvillea x buttiana partitioned originated two phases the aqueous (BxbREaq) and organic (BxbREop) phases were employed in anti-inflammatory activity. Acute inflammation was evaluated using the carrageenan model, whereas the chronic inflammation with anti-arthritic potential was explored with complete Freund´s adjuvant (CFA). Arthritis was caused by intradermal inoculation of CFA, and the extract was administered orally at different doses for 21 d. Paw oedema was determined at 7, 14 and 21 d, and serum from the mice were obtained to detect cytokine levels by ELISA and for biological assays.Results: Phytochemistry studies revealed that these extracts contain alkaloids, carbohydrates, fatty acids, and tannins. The results demonstrated that these extracts significantly inhibited mouse paw oedema for acute and chronic inflammation in a dose-dependent manner. Additionally, BxbREop extracts markedly inhibited the production of TNF-α, IL-1β, and IL-6 and remarkably increased IL-10 in serum from mice with control or arthritic groups.Conclusion: The combined results suggest that BxbREop extract shows a potent effect in mice against CFA-induced arthritis for its ability to inhibit paw oedema and arthritic symptoms.
A COMPARATIVE GENOTOXIC STUDY OF THE METABOLITES OF 2, 6-AND 3,5-DIMETHYLANILINE IN HUMAN LYMPHOBLASTOID TK6 CELLS
Authors: Moon Seo Hyun , Kim Min Young
Published: March 2018

Objective: To characterize the genotoxicity of reactive metabolites of 2,6-dimethylaniline (2,6-DMA) and 3,5-DMA in the hypoxanthine‑guanine phosphoribosyl transferase (HPRT) gene of human lymphoblastoid TK6 cells.Methods: Cultures were exposed to N-hydroxylamine and aminophenol metabolites of 2,6-and 3,5-DMA for 1 h in serum-free medium. Cell survival 24 h after exposure was determined by trypan blue exclusion. Cells were then subcultured for 7-10 d to allow to the phenotypic expression of HPRT mutants. After the expression period, cells were plated in the presence of 2 µg/ml 6-thioguanine for selection of HPRT mutants. Plating efficiency was determined and mutant fraction calculated. Electron Paramagnetic Resonance (EPR) was also used to determine whether 3,5-DMAP-produced reactive oxygen species (ROS).Results: All of the metabolites tested were cytotoxic to these cells but exhibited considerable variation in potency. The aminophenol metabolites of 2,6-DMA and 3,5-DMA were considerably more toxic than the corresponding N-hydroxylamines. Also, each metabolite of 3,5-DMA was more toxic than its 2,6-DMA counterpart; N-OH-3,5-DMA and 3,5-DMAP were clearly mutagenic at a level of 50 µM. EPR studies showed intracellular oxidative stress induced under 3,5-DMAP treatment.Conclusion: Our findings suggest that genotoxic responses of 2,6-DMA and 3,5-DMA are mediated through the generation of ROS by hydroxylamine and/or aminophenol metabolites.
Design of the wastewater treatment system of an office building
Authors: Raissha Rizky , Mardyanto Mas Agus
Published: March 2018

The MIPA Tower office building, an eleven-storey building, which is located in the area of Institut Teknologi Sepuluh Nopember Surabaya, is under construction. The building will be utilized for offices, classrooms, and laboratories. In the operation of the building, domestic and laboratory wastewater will be produced. This wastewater contains compounds that can pollute the environment. A design of domestic and laboratory wastewater treatment system is conducted. The system comprises of a neutralization tank, a grease trap, an equalization tank, an anaerobic filter, and an activated carbon and silica sand filter.

The steps of the design are (i) collecting primary data and secondary data, (ii) calculating the engineering design, (iii) drawing the Detailed Engineering Design (DED), and (iv) calculating the bill of quantity and budget.

The conclusion of this design is that the treatment plant will treat a mixture of domestic and laboratory wastewater. The dimension of each unit is as follows: (i) the neutralization tank (Ã˜ = 0.65 m, H = 0.43 m), (ii) the grease trap (4 m x 2 m x 1 m), (iii) the equalization tank (10.5 m x 5.5 m x 2.5 m), (iv) the septic tank (4.5 m x 4 m x 2.5 m), (v) the six-compartment anaerobic filter (2.25 m x 4 m x 2.5 m), and (vi) the filter with activated carbon (H = 50 cm), silica sand (H = 150 cm), and gravel (H = 10 cm), with the diameter of the tank is 1.5 m.
Remediation of Pb(II) and Cd(II) in Sea Water by Skeletonema costatum
Authors: Soedarti Thin , Surtiningsih Tini , Hariyanto Sucipto , Kuncoro Eko P.
Published: March 2018

The heavy metals that polluted sea water can end up polluting fish pond too. Hence, it is necessary to remove the heavy metals before sea water enters the fish pond. The aim of this study was to know the growth, remediation ability, and the highest of removal efficiency of marine diatom Skeletonema costatum in the lead (Pb(II)) and cadmium (Cd(II)) solution. This study used 3 x 4 factorial design, i.e. concentrations of the cell inoculation (5000 cells mL-1; 10000 cells mL-1; and 15000 cells mL-1) and concentrations of Pb(II) and Cd(II) (0; 0.5; 1; and 2 ppm), replicated five times. During five day exposure time, the cell density was observed daily using a microscope (400X), while filtrate of media was analyzed using AAS. The result showed that S. costatum could grow in Pb(II) and Cd(II) at 2 ppm, and could remediate Pb(II) and Cd(II) at 2 ppm. The highest removal efficiency of marine diatom S. costatum in Pb(II) solution was 80.5% (5000 cells mL-1 at 2 ppm on the first day), and in Cd(II) solution was 80% (15000 cells mL-1 at 0.5 ppm on the fifth day).
On αβ-statistical convergence for sequences of fuzzy mappings and Korovkin type approximation theorem
Authors: Karaisa Ali , Kadak Uğur
Published: March 2018

Upon prior investigation on statistical convergence of fuzzy sequences, we
study the notion of pointwise ??-statistical convergence of fuzzy mappings
of order ?. Also, we establish the concept of strongly ??-summable sequences
of fuzzy mappings and investigate some inclusion relations. Further, we get
an analogue of Korovkin-type approximation theorem for fuzzy positive linear
operators with respect to ??-statistical convergence. Lastly, we apply fuzzy
Bernstein operator to construct an example in support of our result.
Maps preserving 2-idempotency of certain products of operators
Authors: Khodaiemehr Hossein , Sady Fereshteh
Published: March 2018

Let A,B be standard operator algebras on complex Banach spaces X and Y of
dimensions at least 3, respectively. In this paper we give the general form
of a surjective (not assumed to be linear or unital) map ? : A ? B such
that ?2 : M2(C)?A ? M2(C)?B defined by ?2((sij)2x2) = (?(sij))2x2 preserves
nonzero idempotency of Jordan product of two operators in both directions.
We also consider another specific kinds of products of operators, including
usual product, Jordan semi-triple product and Jordan triple product. In
either of these cases it turns out that ? is a scalar multiple of either an
isomorphism or a conjugate isomorphism.
Scalarized solutions of set-valued optimization problems and generalized variational-like inequalities
Authors: Oveisiha Morteza , Aghabagloo Mansoureh
Published: March 2018

In this paper by using the scalariation method we introduced the concept of
relaxed K-preinvex set-valued maps and obtain some equivalence results of
them in terms of normal subdifferential. Also, we consider generalized Minty
variational-like inequalities and show that the set of solutions is equal to
scalarized set-valued optimization problems?s solutions under generalized
relaxed convexity assumptions.
Improvement of an existing method of asynchronous sampling for determining RMS value
Authors: Mirkovic Stefan , Pejic Dragan , Urekar Marjan , Vujicic Bojan , Novakovic Djordje
Published: March 2018

Measuring a value by definition seems to be the best solution for getting the
most precise results. In this paper, it is shown that by changing the
general definition of root mean square (RMS) and average value of a periodic
signal, their measurement can be improved. When measuring RMS with
asynchronous sampling, it was observed that results were scattered around
two values, and it was found that the main cause for this was initial
sampling time. Redefining the RMS value has been proposed in order to
increase the efficiency of the asynchronous method. After comparing the
results based on general and proposed definition for RMS value, it was
observed that there was significantly less scattering of results and higher
accuracy. The simulation proved that the application of the proposed
definition of RMS gives more accurate and precise results than the general
definition for analog to digital (AD) converters with both lower and higher
resolution.
The monastery entrance: Adventus and path to salvation: With 10 illustrations
Authors: Popovic Svetlana
Published: March 2018

This paper deals with monastic entrance as the liminal architectural element
facilitating a transition between outer - lay and inner - sacred worlds. It
examines the architectural design and spatial position of the monastery
entrance as an articulation of its multiple functions, which apparently
crystallized over a long period of time. By the eleventh century the
function of a monastic entrance emerged into a codified model that included
multiple activities. These undertakings necessitated a further elaboration
of its architectural setting including visually recognizable symbolic and
prophylactic elements. Symbolically charged visual content of an entrance
communicated the messages to both lay people and the monks. For outsiders
holy images displayed in the monastic entrance designated the abode for
people who live under the protection of celestial beings. At the same time,
for insiders (monks and nuns), they had multiple meanings both apotropaic
and eschatological signifying an adventus into the other-world, which may
open a path to salvation.
Trattati metabizantini di magia sulla vita Coniugale (BIEE 223 ff. 84r-85v; 210 ff. 37r-v, 63r-v, 82v)
Authors: Costanza Salvatore
Published: March 2018

The article presents magical prayers employed in post-Byzantine manuscripts
from Athenian Library of Historical and Ethnological Association of
18th-19th centuries, in order to ensure protection against impotence and a
happy coupledom. Here, biblical and liturgical texts are often quoted in
closer relation to official life of Greek-Orthodoxe Church. A formulary
shows not trivial knowledge of medical plants and their uses, especially
with anxiolytic effects.
Metodología para auditorías a la información estadística del Convenio Docente de Medicina Familiar en Ecuador
Authors: Yera Isis Belkis
Published: March 2018

Las auditorías son una herramienta de mejora continua de la calidad en los procesos asistenciales y docentes. El objetivo del estudio fue proponer una metodología para la realización de auditorías al sistema de información estadística del Convenio Docente en Ecuador. Se realizó una revisión documental del tema auditoría y su aplicación a las áreas de las ciencias médicas y los sistemas de información estadística. Para determinar los aspectos a auditar y la metodología para la realización del proceso en las unidades docentes asistenciales donde se ejecuta el Convenio Docente, se realizaron revisiones de documentos normativos del Ministerio de Salud Pública y del posgrado de Medicina Familiar y Comunitaria de Ecuador, así como entrevistas a expertos en gestión de salud, sistemas de información estadística y profesionales con experiencia de colaboración docente en Ecuador. Resultaron diseñadas dos guías de auditorías a la información estadística del programa de formación de especialistas en Medicina Familiar y Comunitaria. Los documentos describen el proceso para auditar 29 aspectos de los módulos del sistema estadístico que se corresponden con las actividades intramurales, actividades extramurales y los programas priorizados. La auditoría al sistema de información estadístico constituye una herramienta para evaluar con un enfoque sistémico aspectos del posgrado de Medicina Familiar y Comunitaria, así como para el mejoramiento de los indicadores de salud en las Unidades Asistenciales-Docentes y la gerencia del Convenio Docente en Ecuador.
Efectos del terremoto en la salud mental de personas damnificadas de un albergue en Ecuador
Authors: Cevallos Reyna Eva Hortencia , Ramírez Amat Gustavo
Published: March 2018

Ante un desastre natural las consecuencias para la salud mental de las personas resultan evidentes, por lo que deben ser objeto de atención inmediata. No obstante, el abordaje de los efectos psicológicos no ha tenido mayor interés y relevancia, pese a sus derivaciones psicopatológicas y efectos duraderos que deja en la salud mental de los sobrevivientes. En este contexto, se expone un estudio de tipo descriptivo, cuantitativo y transversal, realizado con personas damnificadas mayores de 18 años, residentes en un albergue durante la fase de post impacto a corto plazo. A estas personas, se les realizó una entrevista y se les aplicó la Escala de Síntomas de Estrés Agudo (EEA), que incluye criterios diagnósticos del Manual Diagnóstico y Estadístico de los Trastornos Mentales (DSM 5), con el objetivo de determinar el grado de afectación psicológica. Como resultado, ocho de cada diez personas del grupo estudiado, presentan síntomas de estrés, que por su persistencia de más de 30 días, requieren atención especializada para reducir la probabilidad de que progrese a un Trastorno de Estrés Postraumático (TEPT). Los síntomas de re-experimentación son los de mayor prevalencia con 80,72%, seguido de disociación 75,90% y alteraciones de la alerta 50,60%. La exacerbación y persistencia de esta sintomatología pudiera vincularse a las constantes réplicas, que reavivaron síntomas intrusivos, sentimientos angustiosos asociados al evento traumático y síntomas de alerta en la población. Estos hallazgos permitirán mejorar las estrategias de gestión de la salud emocional de quienes viven este tipo de experiencia.
Análisis de los instrumentos jurídicos elaborados para la implementación de la Silla Vacía como mecanismo de participación ciudadana en las sesiones de los Concejos Municipales del Ecuador
Authors: Compte Guerrero Rafael
Published: March 2018

Se determina la eficiencia de la Ordenanza, instrumento jurídico que los Municipios elaboran en el marco de su facultad legislativa, a efectos de normar la implementación de la Silla Vacía, para dar cumplimiento al mandato constitucional y legal de posibilitar la participación ciudadana. Se realizó un estudio de las Ordenanzas de veintiséis municipios del Ecuador, sobre la base de establecer cinco categorías de análisis, a efectos de determinar si las mismas cumplían con la norma constitucional y legal que posibilite el acceso de la ciudadanía a esta forma de participación. Se determinó que las Ordenanzas analizadas no posibilitan su implementacion pues incumplen la Constitución y la Ley, por lo que se recomienda una propuesta de Ordenanza que si contempla lo previsto en la normativa existente, esto es, la Constitución de la República del Ecuador, la Ley Orgánica de Participación Ciudadana y el Código Orgánico de Organización Territorial, Autonomía y Descentralización (COOTAD).
Self-Regulation of Learning in Practice Behavior: Exploratory Observation Study of Indonesian Young Badminton Players
Authors: Siegit Listiyani , Richard Hugh
Published: March 2018

Self-regulated learning is an essential skill in maintaining deliberate practice over years, espe-cially for young athletes. Yet, there has not been many studies done on athlete’s practice behavior. This study measured the behavioral correlation of self-regulation of learning in Indonesian young badminton players during practice. There were two parts of this study: first, a list of behavioral items was generated from coach interviews with six expert badminton coaches. Second, the list was used to observe players practice behavior during three separate practices and the observed players were asked to complete a self-regulation of learning questionnaire. Eleven badminton players aged 12 to 19 from different divisions participated voluntarily in this study. The observation and questionnaire results showed good self-regulation of learning in badminton players. However, the components breakdown did not match with coaches’ concept of self-regulated learning. Players were scored high in effort, yet lacking in metacognitive components which led to less proactive behavior in their learning process. This study highlighted the importance of gaining a complete impression of the players’ self-regulated learning skills during practice to develop and maximise their potential.
Nurses’ Competencies in Providing Palliative Care for HIV/AIDS Patients in dr. Ario Wirawan Pulmonary Hospital, Salatiga
Authors: Desi Desi , Ranimpi Yulius Yusak , Anwar M. Aziz
Published: March 2018

The aim of this research was to identify nurses’ competencies (cognitive, psychomotor and af-fective) in providing palliative care for HIV/AIDS patients. Using narrative qualitative approach, data were collected through both structured and non-structured interviews and also direct observations on research participants. Participants in this study were nurses (N = 5) of dr. Ario Wirawan Pulmonary Hospital. Data were coded in accordance to aspects and interview indicators. Result showed that participants did not have information about what and how palliative care should be carried out, and also about SK Menkes No. 812/MENKES/SK/VII/2007 that is targeted at all health professionals. This influenced participants to implement both psychomotor and affective competencies related to palliative care. Factors influencing participants’ lack of knowledge and competencies were personal factor, rooms’ routine, time and limited human resources. HIV/AIDS patients received general care with emphasis on collaborative medical treatments.
“Mi sexualidad es una manifestación política y artística”. Ámbitos de la pospornografía en el México contemporáneo
Authors: Romero López José Antonio
Published: March 2018

La pospornografía emergió como un movimiento político y artístico que llamaba a la reapropiación de la imagen pornográfica para visibilizar otras identidades, cuerpos, prácticas y placeres sexuales fuera del espectro heterosexual masculino que históricamente ha dominado en la pornografía de consumo masivo. La nota de investigación versa sobre los hallazgos y resultados que surgieron tras las entrevistas entabladas con doce artistas y activistas que han desarrollado su trabajo en torno a la pospornografía, dentro del contexto espacial-temporal del México contemporáneo. El propósito del texto es contribuir a la reflexión sobre las formas en que el posporno, como estrategia política de representación de la sexualidad, se ha empleado y comprendido en el contexto mexicano
COMPORTAMENTO DE COMPRA SUSTENTÁVEL: QUAL O GRAU DE INFLUÊNCIA DE SEUS ANTECEDENTES ?
Authors: De Aguiar Fernando Henrique Oliveira , Barrichello Alcides , Morano Rogério Scabim , Amadeu Marcus Vinicius , Pontes Thais Calaça , Gatto Thiago Alago , Melo Wallace
Published: March 2018

Nos últimos anos foram expressas preocupações sobre o impacto dos produtos no meio ambiente. Os consumidores e os fabricantes têm dirigido sua atenção para produtos menos nocivos ao meio ambiente que se presume serem "verdes" ou amigáveis ambientalmente, com baixo consumo de energia, alimentos orgânicos, tintas livres de chumbo, papel reciclável, detergentes sem fosfato, entre outros. Esta pesquisa fornece uma breve revisão da questões ambientais e identifica o comportamento de compra sustentável dos consumidores, seu nível de consciência sobre as questões ambientais e produtos verdes de acordo com as variáveis acessibilidade, consciência sustentável, marca, preço e qualidade. A coleta de dados foi realizada com questionário eletrônico, obtendo-se 302 respondentes. Os resultados revelaram que marca é o fator com maior influência sobre o comportamento de compra sustentável, não havendo preocupação com preço e qualidade. Acessibilidade aos produtos sustentáveis e a consciência sustentável dos consumidores também têm influência sobre suas práticas de aquisição de produtos.
IMPACTO ECONÔMICO DA ESCOLHA DE MODAL DE TRANSPORTE PARA EXPORTAÇÃO DE PRODUTO ELETROELETRÔNICO
Authors: Nunes Débora Porcari , Costa Fabiano , Junior Moacir Freitas , Bueno Robson Elias
Published: March 2018

Atualmente, com frequentes crises financeiras e com o contínuo aumento da competividade entre as organizações, surge a vital necessidade de reduzir os custos de toda a cadeia produtiva, torna-se fundamental para as empresas realizar ações para atender as necessidades dos clientes e satisfazer as suas expectativas em relação à realização de serviços, entrega de produtos e ainda estar de acordo com as normas da qualidade.  Por esse motivo, o desenvolvimento e utilização de modelos teóricos que auxiliem no gerenciamento e escolha do melhor modal de transporte são imprescindíveis. Nesse contexto, a pergunta que rege este artigo é: como e por que uma modalidade de transporte de cargas é mais eficiente que outra para a exportação de produtos eletroeletrônicos sobre a perspectiva de menor custo? O objetivo principal será analisar a utilização demodelos teóricos que possibilitem a obtenção da decisão ótima do modal de transporte que será utilizado para entrega de produtoseletroeletrônicos para a Argentina. A justificativa para esse artigo é de propor a utilização de ferramentas de gestão para alcançar melhores resultados nos processos e custos relacionados ao transporte de mercadorias de uma empresa. Neste artigo são observados os modais rodoviário e hidroviário, perante análises de custos de modal e de acordo com os resultados foram realizadas comparações entre o cenário real e um cenário proposto. Os resultados apontam a importância do uso de ferramentas teóricas para a melhor escolha de modal de transporte.
AVALIAÇÃO DA REDE DE HIDRANTES NA CIDADE DE SÃO CARLOS-SP EM RELAÇÃO A EXPANSÃO URBANA, DENSIDADE POPULACIONAL E AGENTES DE INCÊNDIOS
Authors: Bizerra Rafael Cavalcanti , Segantine Paulo Cesar Lima
Published: March 2018

O número de ocorrências de incêndios tem aumentado ano a ano em várias cidades brasileiras e grande parte destes sinistros é destrutiva e causa mortes. Um dos principais fatores responsáveis pelos resultados negativos relacionados a incêndios é a quantidade insuficiente de hidrantes instalados nas cidades, uma vez que a expansão da malha urbana e os assentamentos da população ocorrem mais rapidamente que a instalação destes equipamentos. Este estudo avalia a distribuição da rede de hidrantes na cidade de São Carlos-SP em relação a agentes de incêndio alocados na cidade e o adensamento populacional. Analisa também a relação entre expansão da malha urbana, crescimento populacional e a presença dos hidrantes, com a finalidade de estimar o crescimento das áreas de potencial risco. Os resultados permitem concluir que a cidade de São Carlos-SP apresenta insuficiência de hidrantes em relação a quantidade indicada pela instrução técnica estadual, que a rede instalada cobre apenas um terço da malha urbana e que apenas parte da população urbana é atendida pelo raio de cobertura destes equipamentos.
Intracoronary versus intravenous adenosine to assess fractional flow reserve: a systematic review and meta-analysis
Authors: Gili Sebastiano , Barbero Umberto , Errigo Daniele , De Luca Giuseppe , Biondi-Zoccai Giuseppe , Leone Antonio Maria , Iannaccone Mario , Montefusco Antonio , Omedé Pierluigi , Moretti Claudio , D’Amico Maurizio , Gaita Fiorenzo , D’Ascenzo Fabrizio
Published: March 2018

Aims

Intravenous infusion of adenosine is the reference method to measure fractional flow reserve (FFR). Intracoronary boluses are often used because of time and convenience, but their effectiveness has yet to be assessed.

Methods

We conducted a systematic review and meta-analysis of prospective studies directly comparing intravenous and intracoronary adenosine administration for FFR measurement. FFR values and prevalence of functionally critical lesions obtained with the different methods of adenosine administration were compared.

Results

Twelve studies evaluating 781 lesions from 731 patients were included (63.7 years, 25.5% women, median FFR 0.82). FFR values were significantly lower with intravenous adenosine than with intracoronary adenosine [mean difference 0.01, 95% confidence interval (CI) 0.00–0.02, P = 0.005], even if no significant differences were observed when only high doses of intracoronary adenosine (≥150 μg) were considered. The prevalence of functionally critical lesions did not significantly differ between intracoronary and intravenous adenosine. Concerning the use of different doses of intracoronary adenosine, low doses (≤60 μg) were associated with higher FFR values (mean difference 0.02, 95% CI 0.01–0.03, P < 0.001) and fewer functionally critical lesions (OR 0.57, 95% CI 0.40–0.81, P = 0.002) compared with high doses. Meta-regression analysis did not show any significant interaction between the way of adenosine administration and main clinical features. Intracoronary adenosine was associated with a higher incidence of atrioventricular blocks, whereas angina and/or systemic symptoms were more frequent with intravenous adenosine.

Conclusion

Intracoronary adenosine might be as effective as intravenous adenosine to measure FFR, provided that adequate doses are used. Intracoronary adenosine represents a valuable alternative to intravenous adenosine whenever appropriately administered.
TÁC ĐỘNG CỦA MỤC TIÊU PHÁT TRIỂN TRONG BÁO CÁO CHÍNH TRỊ TẠI ĐẠI HỘI 19 ĐẢNG CỘNG SẢN TRUNG QUỐC ĐẾN CHÍNH SÁCH ĐỐI NGOẠI ĐỐI VỚI VIỆT NAM
Authors: Anh Nguyen Ngoc
Published: March 2018

Nghiên cứu tiến hành phân tích các mục tiêu phát triển Trung Quốc được thể hiện trong Báo cáo Chính trị tại Đại hội lần thứ 19 Đảng Cộng sản Trung Quốc và tác động của các mục tiêu này đến chính sách đối ngoại của Trung Quốc đối với Việt Nam. Nghiên cứu chỉ ra rằng các mục tiêu này sẽ có cả tác động tích cực và tiêu cực đến chính sách đối ngoại của Trung Quốc đối với Việt Nam với chiều hướng và mức độ tùy thuộc vào nhận thức, mục tiêu và hành vi gia tăng quyền lực của Trung Quốc. Trong tình huống như vậy, quan hệ giữa Việt Nam và Trung Quốc sẽ phụ thuộc nhiều vào phản ứng của phía Việt Nam.
NHỮNG ĐẶC TRƯNG TRONG SÁNG TÁC TRUYỆN NGẮN CỦA NHÀ VĂN AI CẬP YUSUF IDRIS
Authors: Hanh Nguyen Thi Hong
Published: March 2018

Nhà văn Yusuf Idris (1927-1991) được coi là một trong những người tiên phong đặt nền móng cho sự phát triển truyện ngắn hiện đại ở Ai Cập nói riêng và Ả rập nói chung. Những tác phẩm của ông đã mở ra cánh cửa mới cho văn đàn đất nước, ảnh hưởng đến nhiều tác giả trẻ ở thế hệ sau. Vì vậy, việc nghiên cứu những đặc trưng trong các sáng tác truyện ngắn của tác giả này đóng vai trò quan trọng trong quá trình tìm hiểu dòng chảy phát triển văn học hiện đại ở khu vực Ả rập. Trong giới hạn cho phép, bài viết này sẽ tập trung khảo sát bốn đặc trưng chính, nổi bật trong các tác phẩm truyện ngắn của nhà văn Yusuf Idris, đó là: mâu thuẫn giữa tầng lớp giàu - nghèo, nông thôn - đô thị; biểu tượng im lặng; biểu tượng không gian khép kín và sự sử dụng sinh ngữ Ả rập Ai Cập.
Pengembangan Metode Pengelolaan Risiko Kecelakaan Lalu Lintas
Authors: Gaspar Don , Malkhamah Siti , Suparma Latif Budi
Published: March 2018

Kurangnya kapasitas sumber daya terbukti menjadi kendala pengelolaan risiko kecelakaan. Walaupun demikianpenelitian-penelitian terdahulu menunjukkan bahwa sebagian besar faktor penyebab dan pemicu kecelakaanmasih dianalisis secara terpisah, sementara skema pengelolaan risiko terpadu sangat terbatas. Tujuan studiini adalah untuk mengembangkan skema pengelolaan risiko kecelakaan lalu lintas terpadu. Pengembangannyadidasarkan pada hasil investigasi terhadap substansi pengelolaan berbagai pola pengelolaan risiko kecelakaanyang ada. Ditemukan bahwa 1) variabel yang dipakai dalam proses analisis risiko harus tidak saja mengakomodirfactor penyebab dan pemicu kecelakaan melainkan juga variabel-variabel penjelasnya. 2) untuk meminimalkanaspek ketidakpastian dalam metode analisis risiko, penentuan periode, durasi maupun lokasi survai harusdisesuaikan dengan kebutuhan kontekstual di lapangan 3) diperlukan upaya pengembangan skema pengelolaanrisiko kecelakaan yang lebih sesuai dengan mengintegrasikan pengaruh tiap variabel terkait secara menyeluruhdan proporsional. Selain itu, model Jarak Pandang Henti direkomendasikan untuk digunakan dalam analisisrisiko kecelakaan.
Penelitian Kebutuhan Fasilitas Kapal Penumpang yang Responsif Gender di Pelabuhan Balikpapan
Authors: Kusumaning Utami Tri , Chairunnisa Chairunnisa
Published: March 2018

Penyelenggaraan angkutan laut penumpang oleh PT PELNI dengan meninjau adanya perbedaan kebutuhan pengguna jasa transportasi pada penggunaan ruang aktivitas, dimana penumpang perempuan dan laki-laki memiliki kebutuhan yang berbeda, perilaku perjalanan yang berbeda, dan berbagai tingkat akses maka perlu dilakukan analisis lebih jauh terkait kondisi penyelenggaraan penumpang pada saat ini melalui pendekatan analisis kebutuhan gender. Penelitian  ini dilaksanakan dalam rangka untuk meningkatkan kenyamanan dan keamanan  pelayanan angkutan laut penumpang, khususnya  fasilitas-fasilitas pada kapal penumpang yang dapat dikelompokan  berdasarkan responsif gender, sehingga kegiatan ini diharapkan dapat menjadikan rekomendasi dalam rangka meningkatkan pelayanan angkutan laut khususnya kapal penumpang. Metode penelitian yang digunakan adalah metode kuantitatif dan kualitatif.  Instrumen penelitian kuantitatif adalah kuesioner, sedangkan instrumen penelitian kualitatif adalah wawancara mendalam, dan observasi. Analisis data secara kuantitatif dengan menggunakan CSI, sedangkan analisis data kualitatif dengan menginterprestasikan hasil data . Permasalahan pemenuhan fasilitas berdasarkan kebutuhan gender terutama terjadi pada saat kapal mengangkut penumpang dalam  kondisi padat penumpang (melebihi kapasitas), karena 4 indikator (keselamatan, kenyamanan, keamanan, dan kemudahan) tidak sesuai harapan dan standar pelayanan minimum untuk 5 fasilitas kapal yakni akomodasi, keselamatan, medis dan sanitari, ruang publik, dan komunikasi.
Pengaruh Promosi dan Harga terhadap Keputusan Membeli Tiket Maskapai Penerbangan Lion Air Rute Lampung-Jakarta
Authors: Subekti Sitti
Published: March 2018

Penelitian ini dilakukan untuk mengetahui pengaruh promosi, harga dan layanan terhadap keputusan membeli tiket penerbangan Lion Air Rute Lampung-Jakarta. Terdapat 3 (tiga) hipotesis yang diuji dalam penelitian ini. Penelitian dilakukan terhadap 101 sampel penumpang pesawat dari maskapai Lion Air di Bandar Udara Radin Inten II Lampung. Metode pengambilan sampel menggunakan metode Slovin. Data primer yang berasal dari  kuesioner  yang disebar kepada 101 penumpang Lion Air. Pengujian kualitas data dilakukan dengan uji reliabilitas dan validitas. Data primer dianalisis dengan menggunakan analisis regresi berganda. Uji asumsi klasik yang terdiri dari uji normalitas residual, multikolinearitas, heterokedastisitas dan autokorelasi juga dilakukan pada model regresi. Uji t dan uji F dilakukan untuk menguji hipotesis penelitian. Hasil penelitian menunjukkan bahwa seluruh data reliabel/andal dan valid untuk digunakan. Model regresi yang digunakan memenuhi syarat dalam pengujian asumsi klasik. Promosi dan harga memiliki nilai t hitung sebesar 3,987 dan 5,518 dengan tingkat signifikansi 0.00 (kurang dari taraf nyata 5%) sehingga dapat disimpulkan bahwa dengan tingkat kepercayaan 95% pengaruh promosi dan harga terhadap keputusan membeli tiket penerbangan signifikan. Nilai F hitung sebesar 78,508 dengan signifikansi p-value sebesar 0.00 yang lebih kecil dari taraf nyata 5%, artinya dengan tingkat kepercayaan 95% terdapat pengaruh bersama-sama (simultan) yang signifikan antara variabel promosi dan harga terhadap keputusan membeli tiket maskapai penerbangan Lion Air Rute Lampung-Jakarta. Penelitian selanjutnya dapat dilakukan dengan (1) menambahkan variabel lainnya misalnya kualitas pelayanan, (2) memilih sampel penelitian dari maskapai penerbangan lain, (3) membedakan kelas penerbangan bisnis atau ekonomi dan (4) pengambilan sampel pada waktu peak season.
Analisa Komparatif Pengaruh Pertambahan Panjang dan Lebar Kapal Terhadap Lightweight
Authors: Hardjono Soegeng
Published: March 2018

Penentuan ukuran utama kapal khususnya pada dimensi panjang (Lpp) dan lebar (B) kapal pada tahap preliminary design mempunyai pengaruh yang signifikan terhadap perubahan nilai Lwt, biaya produksi dan harga kapal. Hal ini kerap menjadi bahan diskusi serius antara owner dan designer. Untuk mengetahui seberapa besar perubahan Lwt yang terjadi akibat perubahan panjang dan lebar kapal, maka perlu dilakukan penelitian terhadap berat Lwt akibat perubahan panjang dan lebar kapal untuk kapal dengan panjang <100meter menggunakan sistem konstruksi melintang dan kapal >100 meter dengan sistem konstruksi memanjang dengan metode analisa statistik melalui formula regresi polynomial. Hasil analisa menunjukkan bahwa pertambahan Lwt akibat pertambahan dimensi lebar kapal (B) per meter lebih besar bila dibandingkan pertambahan Lwt akibat pertambahan dimensi panjang kapal (Lpp) yaitu 30% berbanding 12% untuk kapal<100m dan 21% berbanding 17% untuk kapal>100m. Pertambahan Lwt 30% lebih besar dari 12% disebabkan kapal dengan Lpp<100 m menggunakan konstruksi sistem melintang yang mempuyai berat struktur lebih besar untuk panjang kapal yang sama.
Kajian Penataan Parkir di Badan Jalan Kota Cirebon
Authors: Puspitasari Reni , Mudana I Ketut
Published: March 2018

Kegiatan parkir di badan jalan merupakan salah satu aktifitas yang dapat mengganggu kinerja jalan karena akan berpotensi menimbulkan kemacetan apabila tidak tertata dengan baik. Hal serupa juga terjadi  di beberapa ruas jalan Kota Cirebon. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik parkir di badan jalan kota cirebon sehingga dapat temukan pemecahan masalah terkait aktifitas parkir di badan jalan. Metode yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Pendekatan deskriptif digunakan untuk menggambarkan kondisi eksisting yang ada di lapangan. Selanjutnya pendekatan kuantitatif dilakukan mengukur karakteristik parkir. Pengamatan di lapangan diperlukan untuk mendapatkan karakteristik parkirnya. Hasil penelitian menunjukkan bahwa permintaan ruang parkir untuk sepeda motor masih memenuhi kapasitas parkir yang tersedia untuk lokasi pengamatan Jl. Siliwangi dan Jl. Kanoman. Sedangkan untuk Jl. Karang Getas dan Jl. Pekiringan sudah melebihi kapasitas parkir yang tersedia. Untuk parkir mobil sudah melebihi kapasitas parkir yang tersedia, kecuali di ruas Jl Siliwangi, permintaan ruang parkir masih memenuhi kapasitas parkir yang ada.
PENGARUH AKRUAL DAN KEPEMILIKAN MANAJERIAL TERHADAP RISIKO LITIGASI
Authors: Purwanti Ari
Published: March 2018

This study aims to investigate the effect of accruals on the occurrence of litigation risk. The higher accruals made by managers are thought to cause high litigation risks as well. Therefore, in this study will also see the effect of managerial ownership on the occurrence of litigation risk. Using a sample of consumer goods industries that often experience litigation, testing is done on 37 companies from 2012 until 2016. The results of this study proves that by using multiple regression, developed hypothesis proved that accruals and managerial ownership have a significant positive effect on litigation risk.
B2 agonist (Salbutamol) modulate skin wound healing processes
Authors: M. Mahmood Fahim , B. Sahib Hayder , W. Qassim Khalid
Published: March 2018

Wound healing is a complex physiological and dynamic process required the coordination of numerous cell types and biological processes to regenerate damaged tissue and initiate repair which is dependent on a number of inter-related factors. This study was aimed to demonstrate whether the ?2 receptor has role in wound healing and angiogenesis. A murine wild-type (in vivo), excisional skin wound model was done to demonstrate that activation of ?2AR delay wound repair, twenty-four male albino mice were used to investigate the effect of the drug on experimental wound healing grossly, histo-pathologically and immune-histochemically compared with vehicle-only controls. The results showed that the rate of wound healing was significantly slower in salbutamol group than in control group (P
Unshared gamma frailty model in Tuberculosis patients
Authors: D Catherine Rexy , G Mokesh Rayalu , C Ponnuraja
Published: March 2018

A natural of survival analysis associated the modelling of time-to-failure, consider the time until death or failure. The frailty model could be a random effect unobserved information, wherever the random effect an increasing, impact of baseline hazard function. The frailty model provides a convenient way to introduce random effects, accounts for further variability from unobserved factors, and heterogeneity into models for survival information. This text planned to analyze the frailty gamma distribution has been active to the parameter distribution acting as Weibull, log logistic and log normal distributions with a naturally incidental variable so as to diagnose the prognostic cause that effect the infectious disease patients for survival time. Information analysis is performed victimization STATA software package.

Keyword: Frailty model; Parametric Distribution; Gamma frailty model -2LL; Tuberculosis Patients
Editorial
Authors: Rosal Marta Alves
Published: March 2018

É com imensa alegria que apresentamos a primeira edição da revista científica do HU-UFPI, concebida com a intenção de contribuir na tomada de decisões e atualizações dos profissionais da área da saúde. A concretização deste projeto foi graças ao trabalho conjunto da equipe da GEP – Gerência de Ensino e Pesquisa do HU-UFPI e da administração superior da UFPI – Universidade Federal do Piauí, uma conquista que muito nos orgulha, pois demonstra uma das importantes funções destas instituições que é a valorização e a promoção da pesquisa científica.
PREVALÊNCIA DE APENDICECTOMIAS E ANÁLISE DOS HISTOPATOLÓGICOS EM HOSPITAL DE URGÊNCIAS DE TERESINA
Authors: Monteiro Marina Stela de Sousa , Reinaldo Gustavo Cavalcante
Published: March 2018

INTRODUÇÃO: A apendicite aguda é a causa mais comum de dor abdominal que necessita de intervenção cirúrgica no mundo. É causada pela obstrução do lúmen apendicular por hiperplasia dos folículos linfoides de origem infecciosa, obstrução mecânica (fecalitos, ascaris, bário, corpos estranhos) ou tumores. A apendicectomia é o tratamento padrão-ouro. OBJETIVO: Estimar a prevalência de apendicectomias em hospital de urgência de Teresina e analisar os histopatológicos. MÉTODO: Trata-se de um estudo quantitativo, descritivo e retrospectivo realizado no Hospital de Urgência de Teresina a partir do livro cirúrgico e banco de dados da instituição em busca dos histopatológicos realizados entre janeiro e junho de 2014. RESULTADOS: Foram realizadas 5987 cirurgias, sendo 298 apendicectomias (4,98%), destas 187 (62,8%) era do sexo masculino e 111 (37,2%) sexo feminino. O histopatológico mais prevalente foi apendicite supurada com 119 casos (45,4%). CONCLUSÃO: A apendicite aguda é comum nos serviços de urgência, sendo a apendicectomia um procedimento com alta prevalência. A análise histopatológica dos casos estudados confirma essa doença e seu caráter benigno.
Globalizazioa eta nazionalismoa: Euskal Nazio Askapenerako Mugimenduaren kasua
Authors: Etxebarria Respaldiza Eki
Published: March 2018

Globalizazio-prozesuak eta nazio-estatuaren krisiak gizarte-mugimenduen diskurtsoetan eragina izan duten bezala, nazionalismoen bilakaera ere eragin dute, Mendebaldeko zenbait eskualderen sezesio-prozesuen berpizkundea ekarriz. Ildo horretan, nazionalismoen diskurtsoaren eboluzioa gertatu da, mugimendu global berrien «demokrazia erradikal»aren ideian kokatuz. Garapen hori Euskal Nazio Askapenerako Mugimenduaren kasuan ere gertatu da, eta «klase-gatazka» edo «iraultza» bezalako kontzeptuak indarra galtzen joan diren heinean, «demokrazia» edo «erabakitzeko eskubidea» diskurtsoaren erdigunean kokatzera pasatu dira. Hori dela-eta, euskal nazionalismo erradikalaren paradigma berri baten aurrean gaude orain, negoziazio-fasetik eraikuntza nazionalera salto eginez, izaera iraultzailetik demokratikora pasatu dena, eta ezker postmaterialistaren ideiak bereganatu dituena.
Peran Kompetensi Sosial pada Orangtua yang Memiliki Anak Autis di Kota Bandung
Authors: Pandin Destalya Anggrainy Mogot
Published: March 2018

Penelitian ini bertujuan untuk memperoleh gambaran mengenai kompetensi sosial pada orangtua yang memiliki anak autis di kota Bandung. Kerangka pemikiran yang mendasari penelitian ini adalah teori kompetensi sosial dari Rubin & Rose Krasnor (1992). Metode penelitian yang digunakan adalah rancangan penelitian non-eksperimental dengan metode deskriptif. Subjek dalam penelitian ini adalah orangtua anak autis di kota Bandung yang berjumlah 100 orang. Instrumen yang digunakan adalah kuesioner Kompetensi Sosial dengan reliabilitas 0.960. Hasil penelitian ini adalah terdapat orangtua yang memiliki anak autis memiliki kompetensi sosial dengan kategori tinggi yakni sebanyak 54 orang, sedangkan 46 orang lainnya memiliki kompetensi sosial dengan kategori rendah. Tinggi-rendahnya kompetensi sosial yang dimiliki oleh orangtua yang memiliki anak autis tersebut tidak terlepas dari kedua dimensi yang terdapat dalam kompetensi sosial, yaitu pemecahan masalah interpersonal (social problem solving), dan keterlibatan dalam interaksi sosial (social engagement). Berdasarkan hasil penelitian ini, peneliti mengajukan saran kepada orangtua anak autis agar memiliki pemahaman secara mendalam mengenai kompetensi sosialnya, sehingga mereka dapat dengan tepat menentukan apa yang sebaiknya mereka lakukan ketika berada pada situasi yang menekan, terutama di lingkungan sekitarnya. Selain itu juga, peneliti mensarankan kepada pihak sekolah agar dapat memberikan support kepada orangtua anak autis dalam memahami kondisi anak mereka sehingga dengan demikian dapat meningkatkan kemampuan kompetensi sosial pada orangtua anak autis tersebut dalam menghadapi lingkungan di sekitarnya.
Pengaruh Kecemasan Berolahraga terhadap Motivasi Berprestasi Atlet Bulutangkis Remaja di Klub J Jakarta
Authors: Clarasasti Evelin Intan , Jatmika Devi
Published: March 2018

Badminton is the largest contributor to Indonesia's sports achievements in the international arena. High achievement motivation necessary for athletes to be able to maximize the achievement. However, there are problems of anxiety experienced by adolescent athletes PB Jaya Raya Jakarta. The purpose of this study was to assess the effect of anxiety to the achievement motivation in adolescent atheletes in PB Jaya Raya Jakarta. This study uses quantitative methods with the type of causal comparative research. The study involved 158 adolescents who have been through the assessment stage of self-criticism with an age range of 15-21 years. Characteristics of the subjects in this study, namely young men and women athletes, aged 12-18 years, and active to practice. Data can be obtained using the research instrument which are then analyzed using SPSS 17. Researcher looked at the effect of self-concept on the purchase intention by using simple linear regression techniques. The analysis results, showing that the anxiety have a significant influence on the achivement motivation. The effect from self-concept by 23,3%, so there are 76.7% other factors that influence. Therefore, it is advisable to adolescent badminton athletes in order to better control the anxiety in the match and more motivated to achievement.