bluuebunny/crossref_metadata_2025 huggingface dataset:
Autologous blood patch treatment of patients with hard-to-heal wounds: a prospective cohort study
Authors: Andersen Jesper Winkler , Dashnaw Birgit , Hoegh Annette
Published: July 2022

Objective:

To describe the effect of autologous blood patch (3CP, Reapplix, Denmark) treatments as a supplement to standard care among patients with hard-to-heal wounds in an outpatient multidisciplinary wound centre (MWC).

Method:

The 3CP is an autologous leukocyte- and platelet-rich fibrin patch, which is applied directly into the wound bed. Patients with a wound duration >6 weeks and an unsatisfactory outcome following standard care were considered. Weekly administration of the autologous blood patch was carried out and the wound size was measured using a picture-based area calculation program at three timepoints (first contact with the MWC, initiation of the autologous blood patch treatment and at the end of the autologous blood patch treatment). The effect was followed for one year or until healing.

Results:

From June 2016 to September 2019, 36 patients were included. The median age was 63.5 years (interquartile range (IQR): 58–70), and 14 patients were female (38.9%) and 22 were male (61.1%). Median wound duration pre-autologous blood patch was 21.5 weeks (IQR: 11.1–50.0) and median treatment time was 3.4 weeks (IQR: 1.6–5.3). Half of the patients (50%, 18/36) healed in <20 weeks, 30.6% (11/36) healed in 20–52 weeks and 19.4% (7/36) did not heal within a year. There was a significant difference between the mean wound area (±standard deviation) at the start of autologous blood patch treatment and the area at the end: 2.85±3.71cm2 versus 1.65±2.37cm2, respectively (p=0.0017). Treatment was stopped prematurely for 5/36 patients (reasons included wound infection, major amputation, procedure discomfort or withdrawal without reason).

Conclusion:

Among MWC patients with hard-to-heal wounds not responding to standard care, autologous blood patch treatment as a supplement to standard wound care expedited wound healing.
A novel activated-zinc antiseptic solution effective against MRSA and Pseudomonas aeruginosa: a pig model
Authors: Hill Derek L , Pinger Cody , Noland Erica L , Morton Kevin , Hunt Alessandra M Agostinho , Pensler Elizabeth , Cantu Sarah , Attar Paul S , Siddiqi Ahmed
Published: July 2022

Objective:

The purpose of this study was to investigate the antimicrobial efficacy of a novel activated zinc solution against meticillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa after one hour, and to evaluate any untoward effect of the solution on local wound tissue at 24 hours after solution exposure in a pig wound model.

Method:

A pathogen-free, commercially raised, Yorkshire-cross female pig was acquired 12 days prior to the procedure. Within one week prior to the procedure, a small loopful of test bacteria, Pseudomonas aeruginosa (pig-isolate) and MRSA (ATCC-6538), were streaked and cultured on a non-selective agar. Full-thickness wounds (n=24) were created and evenly divided into three groups: control wounds (exposed to bacteria but untreated, n=8); wounds treated with Compound 1 (n=8), and wounds treated with Compound 2 (n=8). All wounds were dressed and monitored for one hour and 24 hours.

Results:

After one hour, the wounds treated with Compound 1 and Compound 2 had a mean recoverable total bacteria of 2.8 log colony forming units (CFUs) and 3.5 logCFUs, respectively. After one hour, the wounds treated with Compound 1 and Compound 2 had a mean recoverable MRSA of 2.3 logCFUs and 1.6 logCFUs, respectively (p=0.009). After one hour, the wounds treated with Compound 1 and Compound 2 had a mean recoverable Pseudomonas aeruginosa of 0.3 logCFUs and 0.0 logCFUs, respectively (p=0.000). After 24 hours of exposure to Compound 1 and Compound 2, there was no statistically significant increased necrosis (p=0.12, p=0.31, respectively) or neutrophilic infiltrate (Compound 2, p=0.12) when compared with control wounds.

Conclusion:

The novel activated-zinc compound used in this study demonstrated a 99.5–99.9% reduction in total bacteria, a 99.9–99.98% reduction in MRSA, and 100% eradication of Pseudomonas aeruginosa one hour after exposure. This novel solution may provide another significant tool to treat and/or prevent wound infections.
Zopiclone
Authors: Rees Sharon
Published: July 2022

In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #zopiclone
Prescribing in alcohol use disorders
Authors: Robertson Deborah
Published: July 2022

Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
New professional guidance for independent prescribers
Authors: Winter George
Published: July 2022

With the release of the Royal Pharmaceutical Society's new guidance ‘expanding prescribing scope of practice’, George Winter looks at how non-medical prescribers are perceived by the public and the ethics of their prescribing
Review on Pharmacology of Atropine, Clinical Use and Toxicity
Authors: Aldossary Sara A.
Published: July 2022

Extracts of the deadly nightshade plant, Atropa belladonna, contain a naturally occurring amine, Atropine, which is isolated from Atropa belladonna and other nightshade plants (Solanaceae). The plants are used for making a wide range of drugs. Drug absorption via the mucosal membrane of the stomach is extremely low because the acid gastric contents. Atropine is a prescription pharmaceutical used to treat the symptoms of decreased heart rate (bradycardia). Atropine is also used to suppress salivation and bronchial secretions before to surgery. Atropine can be used on its own or in combination with other drugs. Anticholinergic, Antispasmodic Agents are the class of medications that include Atropine. Toxic side effects include ventricular fibrillation (VF), as well as hypotension (hyperventilation), convulsions (delirium), hallucinations (delirium), convulsions (delirium), delirium (delirium), and excitation (excitation) in the elderly. Except in levels often used for preanesthetic treatment, atropine is generally contraindicated in individuals with glaucoma, pyloric stenosis, or prostatic hypertrophy. In this review the history and pharmacolog of atropine will be discussed in details. In addition to medical uses of this drug and contraindications.
“This work that we're doing is bigger than ourselves”: A qualitative study with community‐based birth doulas in the United States
Authors: Kett Paula M. , van Eijk Marieke S. , Guenther Grace A. , Skillman Susan M.
Published: July 2022

Context

Community‐based birth doulas support pregnant women, transgender men, and gender non‐binary individuals during the perinatal period and provide essential services and expertise that address health inequities, often taking on additional roles to fill systemic gaps in perinatal care in the United States (US). Despite the benefits that community‐based birth doulas provide, there is little research exploring the work‐related conditions and stressors community‐based doulas experience. To address this gap, we examined the work experiences, related stressors, and stress management strategies of individual community‐based birth doulas.

Methods

In this qualitative, descriptive study we conducted 18 interviews in March through June 2021 with individuals who self‐identified as community‐based doulas working in underserved communities in the US. We analyzed the interviews for themes, which we defined and finalized through team consensus.

Results

The doulas reported engaging in specific strategies in their work to address perinatal inequities. They also described facing several work‐related stressors, including witnessing discrimination against clients, experiencing discrimination in medical environments, and struggling with financial instability. To mitigate these stressors and job‐related challenges, interviewees reported they relied on doula peer support and reconnected with their motivations for the work.

Conclusions

Community‐based doulas provide essential services and expertise which address inequities and systemic gaps in perinatal care. However, as they work to improve perinatal health, doulas themselves are providing equity work amidst an inequitable system and with insufficient political or financial support. Increased compensation and systemic support which acknowledges the breadth of services provided is needed to strengthen and sustain this critical part of the perinatal workforce.
High efficiency echelle gratings for the far ultraviolet
Authors: Kruczek Nicholas , Miles Drew M. , Fleming Brian , McEntaffer Randall , France Kevin , Grisé Fabien , McCandliss Stephan
Published: July 2022

Modern grating manufacturing techniques suffer from inherent issues that limit their peak efficiencies. The anisotropic etching of silicon facilitates the creation of custom gratings that have sharp and atomically smooth facets, directly addressing these issues. We describe work to fabricate and characterize etched silicon echelles optimized for the far ultraviolet (FUV; 90–180 nm) bandpass. We fabricate two echelles that have parameters similar to the mechanically ruled grating flown on the Colorado High-resolution Echelle Stellar Spectrograph sounding rocket. We demonstrate a 42% increase in peak order efficiency and an 83% decrease in interorder scatter using these gratings. We also present analysis on where the remaining efficiency resides. These demonstrated FUV echelle improvements benefit the faint source sensitivity and high resolution performance of future UV observatories.
Smart Managed Freight Fleet: Ein automatisiertes und vernetztes Flottenmanagement in einem föderierten Datenökosystem
Authors: Heinbach Christoph , Gösling Henning , Meier Pascal , Thomas Oliver
Published: July 2022

Das starke Wachstum des E‑Commerce stellt bedeutende Herausforderungen an die Betreiber von Fahrzeugflotten, um den kostenintensiven Fahrzeugeinsatz in einem digital getriebenen Transportmarkt zu optimieren. Innovative Fahrzeug- und Datentechnologien bieten dabei neue Möglichkeiten für die serviceorientierte Gestaltung digitaler Ökosysteme mit weiteren Stakeholdern durch cloudbasierte Infrastrukturen. Bei genauerer Betrachtung der Transportkette wurde ein durchgehendes, automatisiertes und vernetztes Flottenmanagement in einem gemeinsamen Datenraum bisher nicht realisiert. In diesem Beitrag stellen die Autoren das Konzept „Smart Managed Freight Fleet“ vor, das im Rahmen des vom BMWK geförderten Konsortialprojekts „GAIA-X 4 ROMS“ (Remote Operation for Automated and Connected Mobility Services) entwickelt werden soll. Dazu zeigen die Autoren zunächst die bestehenden Informations- und Fahrzeugtechnologien für ein vernetztes Flottenmanagement auf. Anschließend wird ein innovativer multiagentenbasierter Flottenmanagementansatz beschrieben, der insbesondere Telematik-gestützte „intelligente Wechselbrücken- und Trailer (iWT)“ mit neuartigen „autonom navigierenden Paketstationen (ANP)“ auf der ersten bzw. letzten Meile verknüpft. Ein sicherer und souveräner Datenaustausch zwischen den Akteuren, Softwareagenten und weiteren Diensten wird dabei durch ein Gaia-X-konformes Datenökosystem erfolgen. Im Anschluss werden die hieraus entstehenden wissenschaftlichen und praktischen Implikationen für ein datenbasiertes Flottenmanagement beschrieben. Abschließend gibt der Artikel einen Ausblick auf die nächsten Entwicklungsschritte zur Gestaltung frei nutzbarer Flottenmanagementdienste in einem interoperablen Datenökosystem.
Reduction in DALYs lost due to soil-transmitted helminthiases and schistosomiasis from 2000 to 2019 is parallel to the increase in coverage of the global control programmes
Authors: Montresor Antonio , Mwinzi Pauline , Mupfasoni Denise , Garba Amadou
Published: July 2022

Preventive chemotherapy interventions for the control of soil-transmitted helminthiases (STH) and schistosomiasis scaled up from a global coverage level of around 5% in the year 2000 to a coverage that surpassed 60% in the year 2019. The present paper analyses the concomitant reduction in the number of disability-adjusted life years (DALYs) lost due to STH and schistosomiasis during the same period, from 6.3 to 3.5 million DALYs. The cumulative gain during the 19-year period was estimated at over 26 million DALYs. Given the low cost of the intervention, our study suggests that deworming for STH and schistosomiasis is one of the most cost-effective public health interventions.
Disseminating implementation science: Describing the impact of animations shared via social media
Authors: Sykes Michael , Cerda Lucia , Cerda Juan , Finch Tracy
Published: July 2022

Background

Dissemination is an under-researched activity that is important to researchers and funders and may have a role in creating conditions for implementation. We aim to study the impact of two animations shared via social media upon dissemination.

Methods

We developed two short animations to increase the awareness of healthcare positional leaders of work undertaken to enhance a much-used implementation intervention. We measured both how frequently the related articles were accessed, and engagement with the research team, before and after the intervention. We analysed variation over time using statistical process control to identify both trend and periods of significant change.

Results

We found evidence that the animation increased how frequently the articles were accessed, with a significant increase (p = <0.01) during the two weeks after release of each animation. One animation was associated with an increase in positional leaders’ engagement with the research team.

Conclusions

Animations shared via social media can enhance dissemination. We describe lessons from the work to develop the intervention and support calls for work to increase the understanding and adoption of effective dissemination interventions. Our findings provide support for further work using randomised study designs.
Post-remission outcomes in AML patients with high hyperleukocytosis and inaugural life-threatening complications
Authors: Fodil Sofiane , Chevret Sylvie , Rouzaud Camille , Valade Sandrine , Rabian Florence , Mariotte Eric , Raffoux Emmanuel , Itzykson Raphael , Boissel Nicolas , Sébert Marie , Adès Lionel , Zafrani Lara , Azoulay Elie , Lengliné Etienne
Published: July 2022

Introduction

Patients with hyperleukocytic (HL) acute myeloid leukemia (AML) are at higher risk of early death. Initial management of these patients is challenging, not fully codified and heterogenous. Retrospective studies showed that several symptomatic measures might decrease early death rate but long-term data are scarce. We aimed to analyze whether the therapeutic measures carried out urgently at diagnosis may influence the outcome among HL AML patients having achieved who survived inaugural complications.

Methods

We retrospectively reviewed all medical charts from patients admitted to Saint-Louis Hospital between January, 1st 1997 and December, 31st 2018 with newly diagnosed AML and white blood cell (WBC) count above 50x109/L. Outcome measures were cumulative incidence of relapse (CIR), treatment-related mortality (TRM) defined as relapse-free death, and overall survival. Univariate and multivariate analyses were performed using Cox proportional hazards models.

Results

A total of 184 patients with HL AML in complete remission (CR) were included in this study. At 2 years after CR. 62.5% of patients were alive, at 5 years, cumulated incidence of relapse was 55.8%. We found that every therapeutic measure, including life-sustaining therapies carried out in the initial phase of the disease, did not increase the relapse risk. The use of hydroxyurea for more than 4 days was associated with a higher risk of relapse. At the end of the study, 94 patients (51.1%) were still alive including 23 patients out of 44 aged less than 60 yo that were able to return to work.

Conclusion

We show that the use of emergency measures including life sustaining therapies does not come at the expense of a higher risk of relapse or mortality, except in the case of prolonged use of hydroxyurea. Patients with HL AML should be able to benefit from all available techniques, regardless of their initial severity.
Comparative analysis of wavelet transform filtering systems for noise reduction in ultrasound images
Authors: Vilimek Dominik , Kubicek Jan , Golian Milos , Jaros Rene , Kahankova Radana , Hanzlikova Pavla , Barvik Daniel , Krestanova Alice , Penhaker Marek , Cerny Martin , Prokop Ondrej , Buzga Marek
Published: July 2022

Wavelet transform (WT) is a commonly used method for noise suppression and feature extraction from biomedical images. The selection of WT system settings significantly affects the efficiency of denoising procedure. This comparative study analyzed the efficacy of the proposed WT system on real 292 ultrasound images from several areas of interest. The study investigates the performance of the system for different scaling functions of two basic wavelet bases, Daubechies and Symlets, and their efficiency on images artificially corrupted by three kinds of noise. To evaluate our extensive analysis, we used objective metrics, namely structural similarity index (SSIM), correlation coefficient, mean squared error (MSE), peak signal-to-noise ratio (PSNR) and universal image quality index (Q-index). Moreover, this study includes clinical insights on selected filtration outcomes provided by clinical experts. The results show that the efficiency of the filtration strongly depends on the specific wavelet system setting, type of ultrasound data, and the noise present. The findings presented may provide a useful guideline for researchers, software developers, and clinical professionals to obtain high quality images.
Bombyx mori Vps13d is a key gene affecting silk yield
Authors: Zhao Luochao , Sun Xia , Wang Xueyang , Qin Sheng , Kong Yunhui , Li Muwang
Published: July 2022

Bombyx mori is an important economic insect, its economic value mainly reflected in the silk yield. The major functional genes affecting the silk yield of B. mori have not been determined yet. Bombyx mori vacuolar protein sorting-associated protein 13d (BmVps13d) has been identified, but its function is not reported. In this study, BmVps13d protein shared 30.84% and 34.35% identity with that of in Drosophila melanogaster and Homo. sapiens, respectively. The expressions of BmVps13d were significantly higher in the midgut and silk gland of JS (high silk yield) than in that of L10 (low silk yield). An insertion of 9 bp nucleotides and two deficiencies of adenine ribonucleotides in the putative promoter region of BmVps13d gene in L10 resulted in the decline of promoter activity was confirmed using dual luciferase assay. Finally, the functions of BmVps13d in B. mori were studied using the CRISPR/Cas9 system, and the mutation of BmVps13d resulted in a 24.7% decline in weight of larvae, as well as a 27.1% (female) decline and a 11.8% (male) decline in the silk yield. This study provides a foundation for studying the molecular mechanism of silk yield and breeding the silkworm with high silk yield.
Panobinostat in combination with bortezomib and dexamethasone in multiply relapsed and refractory myeloma; UK routine care cohort
Authors: Maouche Nadjoua , Kishore Bhuvan , Bhatti Zara , Basu Supratik , Karim Farheen , Sundararaman Sharadha , Collings Freya , Tseu Bing , Leary Heather , Ryman Noel , Reddy Udaya , Vallance Grant D. , Kothari Jaimal , Ramasamy Karthik
Published: July 2022

The combination of panobinostat, bortezomib and dexamethasone (PanBorDex) is available as a treatment option for relapsed refractory multiple myeloma (RRMM) based on the PANORAMA-1 trial which investigated this triplet in early relapse. In routine clinical care, PanBorDex is used primarily in later relapses and is commonly administered in attenuated dosing schedules to mitigate the treatment-related toxicity. We set out to evaluate efficacy and safety outcomes with PanBorDex later in the disease course and evaluate the role of attenuated dosing schedules. This was a retrospective evaluation of patients treated in routine clinical practice between 2016–2019 across seven heamatology centres in the UK; patients who received at least one dose of PanBorDex were eligible for inclusion. The dosing schedule of panobinostat (10mg, 15mg or 20mg, twice or three times a week) and bortezomib (0.7mg/m2, 1mg/m2 or 1.3mg/m2 once or twice weekly) was as per treating physician choice. Patients received treatment until disease progression or unacceptable toxicity. The primary outcome is response rates according to IMWG criteria. Key secondary endpoints include progression-free survival (PFS) and overall survival (OS). Other secondary endpoints include rates of adverse events according to CTCAE criteria. In total, 61 patients were eligible for inclusion and received PanBorDex primarily as ≥5th line of treatment. One third of patients received PanBorDex at full dose, for the remaining two thirds, treatment was given in reduced dose intensities. The overall response rate was 44.2%, including 14.7% very good partial response (VGPR) rates; 68.8% of patients derived clinical benefit with stable disease or better. The median PFS was 3.4 months; non-refractory patients and those who achieved VGPR benefited from prolonged PFS of 11.4 months and 17.7 months, respectively. The median OS was 9.5 months. The triplet was associated with 45% and 18% incidence of grade 3–4 thrombocytopenia and diarrhea, respectively.
Cilostazol effectiveness in reducing drug-coated stent restenosis in the superficial femoral artery: The ZERO study
Authors: Miura Takashi , Miyashita Yusuke , Hozawa Koji , Doijiri Tatsuki , Kato Tamon , Hayakawa Naoki , Hashizume Naoto , Nakano Masatsugu , Ikeda Uichi , Kuwahara Koichiro ,   on behalf of the ZERO Investigators
Published: July 2022

Purpose

Drug-eluting stents (DESs) play an important role in endovascular therapy (EVT) for femoropopliteal (FP) lesions. Cilostazol improves patency after bare-metal nitinol stent (BNS) implantation for femoropopliteal lesions. This study aimed to establish whether cilostazol is effective in improving the patency of DESs and determine whether BNS or DESs with or without cilostazol are more effective in improving the 12-month patency after EVT for FP lesions.

Materials and methods

In this prospective, open-label, multicenter study, 85 patients with symptomatic peripheral artery disease due to de novo FP lesions were enrolled and treated with DESs with cilostazol from eight cardiovascular centers between April 2018 and May 2019. They were compared with 255 patients from the DEBATE SFA study, in which patients were randomly assigned to the BNS, BNS with cilostazol, or DES groups. The primary endpoint was the 12-month patency rate using duplex ultrasound (peak systolic velocity ratio < 2.5). This study was approved by the ethics committee of each hospital.

Results

The 12-month patency rates for the BNS, BNS with cilostazol, DES, and DES with cilostazol groups were 77.6%, 93.1%, 82.8%, and 94.2%, respectively (p = 0.007). The 12-month patency rate was higher in the DES with cilostazol group than in the DES group (p = 0.044). In small vessels, the DES with cilostazol group had a higher patency rate than the DES group (100.0% vs. 83.4%, p = 0.023).

Conclusions

DES with cilostazol showed better patency than DES alone. Cilostazol improved patency after EVT with DES in FP lesions and small vessels.

Clinical trial registration

University Hospital Medical Information Network Clinical Trials Registry (no. UMIN 000032473).
Sleep quality and associated factors among adult hypertensive patients attending a chronic follow up care clinic in northwest Amhara regional state referral hospitals, Northwest Ethiopia
Authors: Ayanaw Teshale , Temesgen Mahlet , Azagew Abere Woretaw , Ferede Yohannes Mulu
Published: July 2022

Introduction

Sleep plays an essential role in every individual’s life since it contributes greatly to their well-being and health. Poor sleep quality is one of the most common consequences of hypertension (HTN), which is a leading public health problem. In Ethiopia, it is the main health concern among hypertension patients. Thus, in the study area, there is limited information regarding the investigation of sleep quality among hypertension patients. Therefore, this study aimed to assess sleep quality and associated factors among adult hypertensive patients attending a chronic follow up care clinic in northwest Amhara regional state referral hospitals, Northwest Ethiopia.

Methods

An institution-based cross-sectional study was conducted among adult HTN patients from March 15/2021 to May 15/2021 in Northwest Amhara Regional State Referral Hospitals. A systematic random sampling method was used to select the study participants. A face-to-face interviewer-administered questionnaire with chart review was used. The Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality was used in this study. A binary logistic regression was used to see the association between dependent and independent variables. Variables having a p-value < 0.05 with a 95% CI were considered statistically significant in the multivariable logistic regression analysis.

Results

In this study, 563 hypertensive patients were included, with a response rate of 96.9%. The overall prevalence of poor sleep quality was 37.7% (95% CI: 33.4%–41.6%). Female gender (AOR = 2.55, 95% CI: 1.55–4.18), age ≥ 65 years (AOR = 4.07, 95% CI: 2.07–7.97), overweight (BMI) ≥ 25 kg/m2 (AOR = 1.68, 95% CI: 1.06–2.65), WHO stage II hypertension (AOR = 1.78, 95% CI:1.01–3.12), poor physical activity (AOR = 2.39, 95% CI:1.41–4.05), participants who had depression (AOR = 2.03,95% CI:1.24–3.34) and participants who had anxiety (AOR = 1.89, 95% CI: 1.16–3.03) were factors associated with poor sleep quality.

Conclusions

In this study, more than one-third of the study participants had poor sleep quality. Female gender, age ≥ 65 years, overweight (BMI) ≥ 25 kg/m2, stage II hypertension, physical inactivity, depression, and anxiety were all associated with poor sleep quality. Managing depression and anxiety disorders, encouraging physical activity, and providing health education about weight loss are all necessary for HTN patients.
Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
Authors: Sakamoto Teruhisa , Makinoya Masahiro , Sunaguchi Teppei , Goto Keisuke , Morimoto Masaki , Murakami Yuki , Miyatani Kozo , Hanaki Takehiko , Shishido Yuji , Kihara Kyoichi , Matsunaga Tomoyuki , Yamamoto Manabu , Tokuyasu Naruo , Fujiwara Yoshiyuki
Published: July 2022

The aim of this study is to investigate the prognostic significance of geriatric nutritional risk index (GNRI) at the time of recurrence in patients with recurrent pancreatic cancer, and the relationship between GNRI and skeletal muscle mass for survival outcomes after recurrence. This study enrolled 77 patients who developed postoperative recurrence. The skeletal muscle mass index (SMI) was used in this study. The patients were divided into a high-GNRI group (n = 36) and a low-GNRI group (n = 41) for the GNRI, and were divided into a high-SMI group (n = 38) and a low-SMI group (n = 39) for SMI. The 2-year post-recurrence overall survival of patients in the high-GNRI group was significantly longer than that of patients in the low-GNRI group (P = 0.001). No significant difference for the 2-year post-recurrence OS curves between the high-SMI group and the low-SMI group was observed (P = 0.125). Upon stratifying the patients with high GNRI or low GNRI according to SMI, There was no significant difference in the 2-year post-recurrence OS curves between the patients with both high GNRI and high SMI and the patients with high GNRI and low SMI (P = 0.399). Similarly, There was no significant difference in the 2-year post-recurrence OS curves between the patients with low GNRI and high SMI and the patients with both low GNRI and low SMI (P = 0.256). Multivariate analysis revealed that the GNRI at the time of recurrence was an independent prognostic risk factor in patients with recurrent pancreatic cancer (P = 0.019). The GNRI at the time of recurrence is useful for predicting the prognosis in patients with recurrence pancreatic cancer. Skeletal muscle mass at the time of recurrence is not contributed to predict post-recurrence survival of patients with recurrent pancreatic cancer.
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection
Authors: Nahas Kamal L. , Connor Viv , Scherer Katharina M. , Kaminski Clemens F. , Harkiolaki Maria , Crump Colin M. , Graham Stephen C.
Published: July 2022

Herpes simplex virus-1 (HSV-1) is a large, enveloped DNA virus and its assembly in the cell is a complex multi-step process during which viral particles interact with numerous cellular compartments such as the nucleus and organelles of the secretory pathway. Transmission electron microscopy and fluorescence microscopy are commonly used to study HSV-1 infection. However, 2D imaging limits our understanding of the 3D geometric changes to cellular compartments that accompany infection and sample processing can introduce morphological artefacts that complicate interpretation. In this study, we used soft X-ray tomography to observe differences in whole-cell architecture between HSV-1 infected and uninfected cells. To protect the near-native structure of cellular compartments we used a non-disruptive sample preparation technique involving rapid cryopreservation, and a fluorescent reporter virus was used to facilitate correlation of structural changes with the stage of infection in individual cells. We observed viral capsids and assembly intermediates interacting with nuclear and cytoplasmic membranes. Additionally, we observed differences in the morphology of specific organelles between uninfected and infected cells. The local concentration of cytoplasmic vesicles at the juxtanuclear compartment increased and their mean width decreased as infection proceeded, and lipid droplets transiently increased in size. Furthermore, mitochondria in infected cells were elongated and highly branched, suggesting that HSV-1 infection alters the dynamics of mitochondrial fission/fusion. Our results demonstrate that high-resolution 3D images of cellular compartments can be captured in a near-native state using soft X-ray tomography and have revealed that infection causes striking changes to the morphology of intracellular organelles.
escenarios tangerinos de Mariano Fortuny y de Francisco Lameyer
Authors: Carbonell i Pallarés Jordi Àngel
Published: July 2022

El artículo es una aproximación a las obras gráficas de Mariano Fortuny que representan Tánger. Se identifica el tema de un número determinado de dibujos y se precisa la fecha de ejecución de algunos de ellos. Dichas creaciones se comparan con las del Álbum de dibujos de tema africano de Francisco Lameyer, mostrando las diferencias en los planteamientos de ambos artistas ante el trabajo del natural y el itinerario visual por los espacios tangerinos que llamaron su atención.
Darwinian functional biology
Authors: Ginnobili Santiago
Published: July 2022

One of the most important things that the Darwinian revolution affects is the previous teleological thinking. In particular, the attribution of functions to various entities of the natural world with explanatory pretensions. In this change, his theory of natural selection played an important role. We all agree on that, but the diversity and heterogeneity of the answers that try to explain what Darwin did exactly with functional biology are overwhelming.In this paper I will try to show how Darwin modified previous functional biology. For pre-Darwinian naturalists did not hesitate to attribute functions in which, for example, the traits of one species were in the service of other species.I will try to show that this has consequences on the discussion regarding the nature of functional language. I will try to show that the main approaches, the systemic and the etiological, do not adequately account for these changes and therefore do not account for the way functional biology regulates the kind of legitimate functions.I will outline a possible new solution to this problem: appropriate functional attributions in Darwinian functional biology could be regulated by a theory or a set of laws that provide the criteria for determining its fundamental concepts.
Inductive risk: does it really refute value-freedom?
Authors: Dressel Markus
Published: July 2022

The argument from inductive risk is considered to be one of the strongest challenges for value-free science. A great part of its appeal lies in the idea that even an ideal epistemic agent—the “perfect scientist” or “scientist qua scientist”—cannot escape inductive risk. In this paper, I scrutinize this ambition by stipulating an idealized Bayesian decision setting. I argue that inductive risk does not show that the “perfect scientist” must, descriptively speaking, make non-epistemic value-judgements, at least not in a way that undermines the value-free ideal. However, the argument is more successful in showing that there are cases where the “perfect scientist” should, normatively speaking, use non-epistemic values. I also show that this is possible without creating problems of illegitimate prescription and wishful thinking. Thus, while inductive risk does not refute value-freedom completely, it still represents a powerful critique of value-free science.
"Truth" and "Law" in Russian Legal Consciousness: Conservative and Theological Motives
Authors: Vasiliev Anton , Zelenin Yuri
Published: July 2022

The article analyses the problem of correlation between the categories of "truth" and "law" in Russian legal consciousness. The authors focus on the study of this issue mainly on the example of Russian conservative thought, justifying it by the fact that of all the theories of legal understanding only conservative legal ideology was able to express the traditional perception of law for the Russian legal consciousness. It was conservative legal scholars who drew attention to the fact that the essence of law in Russian culture is determined by the traditional worldview, which was formed back in the V-IX centuries and continues to dominate at present. It is noted that traditionally Russian legal consciousness in contrast to the European is characterized by such features as syncretistic unity of religious, moral and legal principles, united by the ideal of Pravda; the prevalence of internal, conscientious over external, formal legal side of law; lack of tangible influence of Roman law on the Russian legal tradition to the beginning of XX century. The priority of the ideals of collegiality, social service and duties; the prevalence of customary, unwritten law, expressing the people's ideals of truth, conscience, and justice. Based on the works of Hilarion, I.S. Peresvetov, I.T. Pososhkov, A.S. Khomyakov, I.S. and K.S. Aksakovs, I.V. Kirievsky, I.A. Ilyin, A.I. Solzhenitsyn, they come to the conclusion that the tradition of distinguishing law and law, pravda (grace, conscience) and formal jurisprudence is deeply rooted in Russian national culture. However, disobedience to external, positive law was justified by conservatives only under the condition of the spirit of law - the provision of religious and moral pravda. Morover, following the "letter of the law" only leads in specific legal situations to an unjust and immoral legal solution.
Negative Aspects of Using the Concept of "Empire" to Determine the Geopolitical Nature of the Russian State
Authors: Nasyrov Rafail
Published: July 2022

The purpose of the article is to reveal the negative aspects of using the term "empire" to characterize the Russian state and determine its geopolitical  nature. The research is based on  the achievements of a linguistic turn in socio-humanitarian studies, which have not yet been adequately taken into account in legal science. Leximes, as units of a particular language, do not simply denote certain phenomena of the surrounding world, but function as peculiar entities that determine the horizons of a native speaker, a particular picture of the world including value preferences and attitudes. It is recognized that  in social communication don’t function abstract definitions, but rather concepts that predetermine the real content of discourse. Attention is drawn to the fact that in modern scientific and public discourse there is a process of revival of the term "empire" in the positive sense of the word. But the foreign term "empire" and the corresponding concept "empire" are not relevant to Russia, because they do not reflect the actual history of the emergence and formation of the Russian state. In the chronological framework of the New Age and Modern History, it is proposed to introduce a fundamental difference between colonial empires and territorial powers. On the one hand,  it will be objective to say about the British and Russian empires  that they used to have a vast territory with a populations that were diverse in ethnic, religious and cultural aspects. But, on the other hand, in form and essence, these were different territorial and political entities. In the course of deliberately obscuring this difference, a political myth was created about Russia as a "prison of peoples", which, unfortunately, was accepted by the majority of the domestic intelligentsia. In relation to the issue of ratio between the concepts of "empire" and "state" the conclusion has been made about the need to overcome the compiling-imitative style of Russia's development, which should be manifested in a more careful attitude to the development of a system of scientific and legislative terms that define the nature of Russian society and the state.
On the Definition of Doping and Сriminal Liability for its Use
Authors: Tydykova Nadezhda , Kovalenko Ekaterina
Published: July 2022

The article covers the study of the concept of “doping” in Russian law and international acts. The importance of this issue for both domestic and international legislation is recognized. Both scientific and legislative definitions of the concept under study are given and analyzed. The authors come to the conclusion that the existing criticism of current definitions, as well as the constant development of technologies, require research to formulate new relevant concepts. Two corpora delicti have been studied, both of them established criminal liability for certain actions performed with substances and by means of methods prohibited for use in sports. Through criticism of the elements of these offenses, the authors prove that in order to form a correct and uniform practice of their application, it is necessary to make a number of changes to the studied offenses. The criticism of the elements of the object and the victim in the studied corpora delicti is analyzed. It is noted that the characteristics of the subject of these crimes pose difficulties for qualification due to the uncertainty of its characteristics. At present, it is possible to formulate specific proposals in regards to  special subjects only in terms of probabilistic assumptions and recommendations, since there is no established judicial practice. It is also noted that the issue of differentiating criminal liability for the actions under study, depending on the presence or absence of qualifying factors is premature. A proposal was made to supplement one of the corpora with new qualifying factors. An assessment is made of the proposals of other authors on improving the dispositions of the studied norms, determining their place in the Criminal Code of the Russian Federation and supplementing the current Criminal Code of the Russian Federation with a new corpus delicti that encroaches on similar social relations.
Rentolog Electric Water Technology
Authors: ojugbani onyeka
Published: July 2022

When water is supplied to the tank, the water flows into a region, the region is blocked by an arc as in your conventional dam, the pressure of the water will increase, the arc opens and the pressure reduces. According to Bernoulli principle, the lower the pressure increases the speed of the fluid(water) and higher the pressure, the speed (velocity) reduces. The water speed is maintained by Pascal principle, which states the fluid at a point or region is evenly distributed . The flow to a region of empty space , gravity and magnetic field of the magnet pull it towards the turbine as in the mountain fall. As the water turns the turbine , Faraday law of magnetic field will occur. a small electric current will be supplied to the coil and the rotor which strengthens the electricity and supplies it to the battery, and your home. The water will flow back to the tank passing through the non-return valve to continue the thermodynamic flow equation. This process conserves energy and requires minimum electricity to operate and also it is efficient. The body of the RET system is made of an insulator to prevent escape of electricity.
POTENSI DESA DAN STRATEGI PENERAPAN EKONOMI ISLAM DALAM PENGELOLAAN BISNIS BUMDES
Authors: Ash-Shiddiqy Muhammad
Published: July 2022

This research departs from the not yet optimal role of the BUMDes institution as a village business driver that carries a social mission and commercial mission in the three villages that are the objects of this research, namely Rompo Village, Karumbu Village and Rupe Village. From this, the two main problems to be answered are what is the potential that can be managed for the development of BUMDes business units and how is the strategy for implementing Islamic economics (sharia) in managing BUMDes business. To answer these problems, the researcher uses two analyzes as a theoretical framework, village potential analysis, and SWOT analysis (Strengths, Weaknesses, Opportunities, and Threats). The results of the research analysis are the potential business sectors that deserve to be developed are businesses in the real sector (agriculture, livestock and fisheries), trade, tourism, and agro-industry sectors. While the results of the SWOT analysis recommend (a) S-O Strategy; The BUMDes Business management approach uses Islamic principles with a business unit management strategy based on the real sector and business units of Islamic microfinance institutions. (b) W-O Strategy, HR development strategy and entrepreneurship (c) S-T Strategy, Islamic economic implementation strategy. (d) W-T Strategy; Build awareness and motivation to work and be alliance with Islamic concepts, Instill values ​​of concern for local village products, Increase participation of business actors and Develop several business lines
PENANGANAN SAMPAH RUMAH TANGGA MELALUI BUDIDAYA LARVA BLACK SOLDIER FLY (BSF) DI TPS 3R TIRTO ASRI PADUKUHAN MRISI, KELURAHAN TIRTONIRMOLO, KABUPATEN BANTUL
Authors: Fajria Nisa , Ayyub Kamal Hidayatullah  , Alfine Alfarizhi  , Muhamad Faisal Madani  , Rinto Hermawan  , Syaifana Adilla Ali  , Inas Nur Faizah
Published: July 2022

Dependence on imports of animal feed makes the price of animal feed expensive. On the other hand, feed costs are known to account for 70%-80% of the total production costs. This condition causes the production efficiency to be low. Utilization of alternative protein sources whose availability is abundant and does not compete with human food needs, is one of the promising solutions to optimize production efficiency. Various types of insects have the potential to be used to produce useful biomass, but the ones that have begin to be studied are the larvae of the Black Soldier Fly (BSF) or Hermetia illucens, the maggot/larvae of the house fly (Musca domestica) and the hongkong caterpillar. KKN (Community Service Program) members analyzed “Mrisi” for the cultivation of BSF larvae from looking for seeds, making a place for BSF larvae, mini experiments and distributing the harvest to the community. The BSF larvae cultivation program in Mrisi is proceeding as planned. TPS Tirto Asri has great potential in the process of cultivating BSF larvae. Good initial planning will result in good production too.
Moins Trois
Authors: De Raedt Nele , Pytowski Yoel
Published: July 2022

Résumé. Ce partage d'expérience à propos d'une installation artistique, réalisée de septembre à décembre 2021 dans le cadre de MAGMA la 10e Triennale d'art contemporain d'Ottignies–Louvain-la-Neuve, met en évidence plusieurs questions : Comment concilier dans un même projet artistique les finalités d'une chercheuse en architecture et d'un artiste visuel ? L'installation traduit-elle seulement des résultats de la recherche, ou possède-t-elle un rôle plus actif dans un projet, qui se définit comme recherche-création ? L'association de la recherche en architecture et de l'installation artistique génère-t-elle plutôt de nouvelles connaissances ou plutôt de nouvelles questions ?

Abstract. This shared experience in the creation of an art installation for MAGMA, the 10th Triennial of contemporary art of Ottignies-Louvain-la-Neuve, from September to December 2021, highlights several questions: How can the aims of a researcher in architecture and a visual artist be combined in one artistic project? Does the installation merely translate research results, or does it have a more active role in projects combining research with creation ? Does the combination of architectural research and artistic installation generate new knowledge, or rather new questions?
Situaciones de discapacidad de las víctimas del conflicto armado residentes en Montería
Authors: Negrete Doria Eduardo Felipe
Published: July 2022

Este artículo de resultado, tiene como objetivo determinar las estrategias jurídicas y políticas del Gobierno Municipal de Montería para implementar mecanismos de rehabilitación y reparación integral de las víctimas en situación de discapacidad. La metodología, obedece a un estudio descriptivo y cuantitativo con recolección de información documental, de carácter etnográfico con aplicación de encuestas y entrevistas aplicadas a 16 personas, cuatro de ellas como prueba piloto, más cuatro exmilitares y ocho víctimas residentes en la ciudad, cuya información permite identificar un incremento de la población que exige atención pronta para disminuir sus necesidades básicas insatisfechas que ameritan claridad sobre la implementación de los mecanismos gubernamentales usados. Se adoptó la teoría de la justicia de Jhon Rawls, en cuanto coadyuva la tesis del bienestar general e inclusión social por parte del estado dentro del marco de la justicia transicional, en un contexto, que obliga a revisar los mecanismos de cumplimiento de compromisos internacionales y nacionales establecidos en las normativas y principios del derecho internacional público que imponen la necesidad de la reinversión y redistribución de los recursos, concluyendo que en el caso particular hacen falta adelantar unas políticas integrales de atención a las víctimas con especial situación.