bluuebunny/crossref_metadata_2025 huggingface dataset:
The operation of Troyanov - Trendelenburg in the modern minimally invasive approach to the treatment of varicose disease with endovenous laser photocoagulation
Authors: Akhadov R A , Sazonov A B , Sizenko V V , Khubulava G G
Published: July 2021

Despite the widespread and active introduction of new minimally invasive technologies in clinical phlebology, the Troyanov - Trendelenburg operation today is an important step in the extensive complex of various methods of surgical treatment of varicose veins of the lower extremities. This intervention can be performed under local anesthesia with minimal trauma and excellent cosmetic results. The leading position in the treatment of chronic venous diseases currently takes endovenous laser photocoagulation, the implementation of which is being offered now even to patients with complicated and advanced forms of the disease. The combination of Troyanov - Trendelenburg operation and laser thermocoagulation can significantly reduce the risk of downward recanalization of the great saphenous vein, as well as eliminate side effects and complications that occur during traction of the vein. To eliminate technical errors in the course of ligation of great saphenous vein in the area of sapheno-femoral anastomosis under local infiltration anesthesia and to simplify the detection of the target vessel, especially in obese patients with severe subcutaneous fat, we have developed a method for performing Troyanov - Trendelenburg, which decreases the time of the surgical treatment of the mouth section is up to 10-15 min; the risk of possible complications is reduced. In addition, this treatment does not increase the bed-day and recovery periods. It was concluded that the use of a laser beam at the end of the working part of the fiber, previously carried out under ultrasound control directly into the area where the great saphenous vein falls into the deep system, as a visual guide, greatly facilitates the search for the main saphenous vein, especially in obese patients. The operation of Troyanov -Trendelenburg allows you to process all branches of the Delbe beam and eliminate the continued progression of thermally induced thrombosis proximal to the anastomosis, and therefore possible pulmonary thromboembolism from the large subcutaneous vein subjected to laser coagulation.
Development of nomograms to assess the risk of clinical outcome
Authors: Korneenkov A A , Kuzmin S G , Dergachev V B , Borisov D N
Published: July 2021

A methodology is presented for developing nomograms for assessing and stratifying the risk of a clinical outcome based on the created virtual data set using the R software environment. The virtual data set included input numerical and factor variables (variable types correspond to the R software documentation) and outcome. For quantitative variables, descriptive statistics were calculated at all levels of the outcome variable, and mosaic diagrams were constructed for factor variables. As a model that describes the association of input variables with the outcome, a logistic regression model was used. A bootstrap method was applied to validate and evaluate the model performance. The calculated validity indicators showed an acceptable discriminatory ability of the predictive model. The statistical calibration demonstrated the proximity of the model’s calibration curve to the ideal calibration curve. Based on the logistic regression coefficients, a nomogram was constructed using which the risk value of a specific outcome was calculated for each subject (patient). It is shown that with the help of the presented technique it is possible to stratify patients effectively by the risk of an adverse outcome, thus adequately altering the diagnosis and treatment tactics. The use of a nomogram greatly simplifies risk assessment and can be used in paper form as a supplement to the patient examination protocol. The article contains the codes of the R programming language with explanations.
The role of subclinical hypothyroidism in lipid metabolism disorders
Authors: Volkova A R , Dygun O D , Galkina O V , Belyakova L A , Bogdanova E O
Published: July 2021

Subclinical hypothyroidism is common in general practice. The clinical significance of latent thyroid dysfunction has not yet been determined. The parameters of lipid metabolism and oxidative stress were studied in patients suffering from subclinical hypothyroidism between the ages of 18 and 50 years. They had a level of thyroid stimulating hormone ≥4 mIU/l, the level of free thyroxine was normal. The control group consisted of healthy individuals with thyroid-stimulating hormone level of 0,4-2,4 mIU/l. Thyroid status, thyroid peroxidase antibodies, lipid profile, malondialdehyde-modified low-density oxidized lipoproteins, antibodies to low-density oxidized lipoproteins, homocysteine were determined for all individuals. With the repeated determination of thyroid-stimulating hormone in 16,8% patients spontaneous recovery of thyroid-stimulating blood hormone level was observed, which was associated with lower values of thyroid-stimulating hormone and the absence of thyroid peroxidase antibodies. In the group of patients with thyroid stimulating hormone levels ≥7 mIU/l, the total cholesterol level was significantly (p=0,02) higher than in the control group. In patients with elevated values of malondialdehyde-modified oxidized low-density lipoprotein, thyroid stimulating hormone level of ≥7 mIU/l was more frequently detected. A negative correlation was found between the level of IgG antibodies to low-density oxidized lipoproteins and the concentration of free thyroxin. In the control group, the correlation was found between the concentration of IgG antibodies to low-density oxidized lipoproteins and the level of thyroid-stimulating hormone. In the group of subclinical hypothyroidism, the concentration of homocysteine was significantly (p=0,01) higher in men. In patients with subclinical hypothyroidism, more often hyperhomocysteinemia was detected compared with the control group. The results suggest that subclinical hypothyroidism is associated with initial changes in the metabolism of lipids and homocysteine.
Т- lymphocytes - «censorial» cells of immune system
Authors: Moskalev A V , Gumilevskiy B Yu , Apchel A V , Tsygan V N
Published: July 2021

The characteristic of population Т-lymphocytes is presented. The variety of effects of these cells is connected with presence of many subpopulations which name small subpopulations helper T-lymphocytes: Тh1, Тh2, Тh3, Тh9, Тh17, Тh22. Mechanisms of activation of these cells and their role in development of mechanisms of the adaptive immune answer, and also possible variants of development of immune dysfunctions and an immune pathology are described. However, the leading part is allocated to the characteristic regulatory T-lymphocytes. From all subpopulations regulatory lymphocytes subpopulation CD4+CD25+high-Т-lymphocytes. Regulatory function autoimmunity а from these cells is most well investigated is shown already at early age. Given subpopulЫation Т-lymphocytes is capable to render suppressor influence on various types immunocompetent the cells providing functioning both congenital, and got immunity. Very important role in functioning CD4+CD25+high-Т-lymphocytes belongs transcriptional to factor FoxP3. It is established, that FoxP3 renders negative effect on activation of T-cells, possibly, owing to oppression efferent functions interleukin 2. Suppressor the effect of these cells is not limited to the T-cells specific to self-antigens. Their influence extends on all microenvironment lymphocytes. Regulatory function CD4+CD25+high-Т-lymphocytes is carried out by means of rendering cytotoxic effect on a cell-target by means of perforins, granzyme A and CD18 without participation of a Fas-receptor. CD4+CD25+high-Т-lymphocytes can render suppressor effect through production transforming growth the factor and expression him on a membrane of a cell. Except for these cells are described Тh3-lymphocytes and inducible regulatory cells. Effects which they cause, are connected with production transforming growth the factor, interleukins 4 and 10. The given biological functions lead to oppression of production of antibodies plasmacytes and modulate presenter activity of macrophages and dendritic cells.
Diagnosis and prevention of infectious complications of acute pancreatitis
Authors: Ivanusa S Yu , Lazutkin M V , Chebotar A V
Published: July 2021

Based on the analysis of domestic and foreign literature, promising and most frequently used methods of diagnosis and prevention of infectious complications of acute pancreatitis are highlighted. The literature increasingly raises the question of the insufficient efficiency of the study of the concentration of C-reactive protein and procalcitonin samples and suggests new markers of systemic infection. The interest of experts in recent years turned to the study of CD64-neutrophil index, which showed a number of advantages over the previously mentioned methods of diagnosis of infectious complications of acute pancreatitis. Presepsin is actively investigated from humoral markers of inflammation. In prospective studies, he also showed high sensitivity and specificity in the diagnosis of pancreatogenic infection. Approaches to the study of the cultural composition of flora in the developed infectious complications have changed. Gas chromatography - mass spectrometry and matrix associated laser desorption/ionization combined with time-of-flight separation and ion detection mass spectrometry are successfully used in this field. From the methods of prevention of infectious complications of acute pancreatitis actively investigated the effectiveness of minimally invasive surgical techniques, selective intestinal decontamination, alternative routes of administration of drugs. In this area, the latest trend is the most popular, which is confirmed by publications on the effectiveness of endarterial and endolymphatic administration of antibiotics and other drugs. Unsolved problems of accurate prediction, prevention, timely diagnosis of infectious complications of acute pancreatitis justifies the urgency of the problem and the need for further comprehensive research in this area.
Unique transcriptome features of pea (Pisum sativum L.) lines with differing responses to beneficial soil microorganisms
Authors: Afonin Alexey M. , Gribchenko Emma S. , Zorin Evgeny A. , Sulima Anton S. , Romanyuk Daria A. , Zhernakov Alexander I. , Shtark Oksana Yu. , Akhtemova Gulnar A. , Zhukov Vladimir A.
Published: July 2021

BACKGROUND: Garden pea (Pisum sativum L.) possesses the ability to form beneficial symbioses with various soil microorganisms. However, different pea cultivars, genotypes, and lines gain more or less benefit from these interactions, so the trait named efficiency of interaction with soil microorganisms (EIBSM) was suggested to describe this phenomenon. The molecular mechanisms underlying the manifestation of the EIBSM trait are not properly studied, and only few works focusing on plant responses to combined microbial preparations have been published to date.
METHODS: Eight pea lines previously described as contrasting in manifestation of the EIBSM trait were grown in pots with soil under combined inoculation with nodule bacteria and arbuscular mycorrhizal fungi, and the transcriptome profiles of the whole root systems of the plants were investigated using 3'MACE RNA sequencing.
RESULTS: The relatedness of the lines inferred from the analysis of transcripts SNVs (Single Nucleotide Variants) corresponded to the manifestation of the EIBSM trait: three high-EIBSM lines and three low-EIBSM lines formed two distinct clusters. Thus, the gene expression profiles were compared between these two clusters, which enabled identification of transcriptome signatures characteristic for each group. The lines previously described as high-EIBSM have lower symbiotic activity, and the expression levels of pathogen response genes were elevated compared to the lines with low EIBSM.
CONCLUSION: This result suggests that the mechanism of high interaction efficiency may be connected to stricter host control of symbionts, allowing such plants to expend less on the symbioses.
“Listen to the Masters!”: An Old Uyghur Maitreya Praise
Authors: Zieme Peter
Published: July 2021

The veneration of Maitreya is one of the important specifics of Old Uyghur Buddhism. There are numerous praises expressing the fervent wish to meet Maitreya, the Buddha of the future. Many of these praises are written in quatrains with strophic alliteration. In this paper, three fragments of the Serindia Collection of the Institute of Oriental Manuscripts of the Russian Academy of Sciences (IOM, RAS) are published. Of special interest are some probable references to Chan Buddhism.
The Concept of “Contemporary Place Names” in the Tibetan Translation of the Da Tang Xiyu Ji
Authors: Takata Tokio
Published: July 2021

The Da Tang Xiyu ji (Тhe Great Tang Records on the Western Regions) was translated into Tibetan by the Mongolian scholar Gombojab (Mgon-po-skyabs) of the Qing dynasty (16441912), using the original Chinese text of the Qianlong Tripitaka, also called the Dragon Tripitaka. In the manuscript copy kept at Otani University (Kyoto), interlinear explanatory notes of the contemporary place names are found. The notes on the Central Asian place names might reflect the new geographical knowledge that Chinese society obtained after Qianlongs campaigns against the Dzungars. In the present paper, the author discusses some of these notes. As the notes are not accurate and contain much misunderstanding, it is hard to use them as research sources. Nevertheless, they reveal the scope of knowledge of the time and deserve attention.
A Unique Manuscript of the Shibanid Epoch from the Fund of the Center of the Written Heritage of Tajikistan
Authors: Dodkhudoeva Lola N.
Published: July 2021

The article introduces the results of a preliminary study of the unique work, the Manaqib al-khulafa (The Virtues/Excellences of the Caliphs) compiled by Qawam ad-Din Muhammad al-Husaini alSanaujiradi al-Ziyaratgahi al-Harawi in 997/1588. This is a response to the protest message of the Shiites of Herat, who survived the siege and capture of the city by the Sunnis the Shibanid troops. The Manaqib recreates the early stages of the history of Islam before the split caused by the difference in the understanding of principles of the supreme political power (elective or hereditary) transfer and reveals the virtues of the four righteous caliphs. Fragments of the Quran and hadiths cited in the treatise present irrefutable evidence of the Sunnis superiority over Shiism. The treatise is an excellent example of polemical literature of bitter ideological struggle between two orthodoxies Sunni and Shiite and contains valuable information on the religious and political history of Eurasia in the premodern period.
Sistem Keamanan Model Sidik Jari (Digital Key Security) Menggunakan Pemrograman Arduino Pada Sepeda Motor
Authors: Pratomo Danang Yugo
Published: July 2021

Abstract: The fingerprint-type digital key model driving safety system offers an accurate security system in minimizing motorcycle units from potential theft crimes that are rampant. This study aims to develop a security system for a fingerprint model on a motorcycle using the arduino-based prototype development method. The test was carried out to determine the results of the arduino programming configuration on the board with a fingerprint scanner. Research results: 1) the design processed using the Arduino application shows that done compiling means that the configuration is successful. 2) The fingerprint scanning test results show that the ignition of the starter is faster when the palm of the finger is dry; that is, the average is activated 2.31 seconds. 3) The result of detection on unknown finger will be activate the alarm. Keywords: Security system, Fingerprint, Arduino application
Penguatan Pendidikan Karakter Siswa SD Melalui Pembiasaan pada Pembelajaran Jarak Jauh
Authors: Widayat Kevinna Risqy Agma , Akbar Sa’dun , Nawawi Imam
Published: July 2021

Abstract: This research focuses on PPK (Strengthening Character Education) activities through habituation in distance learning and to interpreting the role of habituation in the context of PPK (Strengthening Character Education) in distance learning at SDN Kotalama 1 Kota Malang. In order for the results of this study to be more accurate, the researchers used mixed methods. The approach used is a quantitative approach and a qualitative approach. The results of this study are the role of PPK (Strengthening Character Education) activities through habituation in distance learning that is not maximal in seeing the attitudes and behavior of students directly. The role of PPK through habituation in distance learning, namely as a controller and introduction to various daily activities at home for students. The implementation of PPK through habituation is carried out every morning before learning activities begin.

Abstrak: Penelitian ini berfokus pada kegiatan PPK (Penguatan Pendidikan Karakter) melalui pembiasaan pada pembelajaran jarak jauh dan bertujuan untuk memaknai peranan pembiasaan dalam konteks PPK (Penguatan Pendidikan Karakter) pada pembelajaran jarak jauh di SDN Kotalama 1 Kota Malang. Agar hasil penelitian ini menjadi lebih akurat maka peneliti menggunakan metode penelitian campuran atau mixed methods. Pendekatan yang digunakan yaitu pendekatan kuantitatif dan pendekatan kualitatif. Hasil penelitian ini yaitu peranan kegiatan PPK (Penguatan Pendidikan Karakter) melalui pembiasaan pada pembelajaran jarak jauh kurang maksimal dalam melihat sikap dan perilaku peserta didik secara langsung. Peranan PPK melalui pembiasaan pada pembelajaran jarak jauh yaitu sebagai pengontrol dan pengenalan berbagai kegiatan sehari-hari di rumah bagi peserta didik. Pelaksanaan PPK melalui pembiasaan dilaksanakan setiap pagi sebelum kegiatan pembelajaran dimulai, guru memberikan kegiatan melalui grup whatsapp dan peserta didik mengirimkan bukti berupa foto atau video saat melaksanakan kegiatan PPK kepada guru.
Analisis Dampak Negatif Penggunaan Smartphone pada Pembelajaran Daring Ditinjau dari Perilaku Anak Kelas V SD
Authors: Wulandari Soniya Putri , Umayaroh Siti , Mahanani Putri
Published: July 2021

Abstract: This study is aimed to discover the negative impacts on the use of smartphone in children, their causing factors, and the means to minimalize them. This study used a qualitative research method with case study research type. The result of this study showed that the negative impacts of the use smartphone were: (1) addicted to play smartphones, (2) less discipline, (3) frequently told lies, (4) slower in understanding the lesson, and (5) influence on their behaviors. Factors that caused those negative impacts were (1) little supervision and limitation on the use of smartphones from parents, (2) the parents always obey all the students wishes, (3) addicted to online games , and (4) influence from the students’ environment. The means that can be done in order to minimize the negative impacts were (1) the teachers should give the clear schedule of online learning (2) the parents should give time limitation on the use of smartphones, and (3) the parents monitor the applications that used by the students.

Abstrak: Penelitian ini bertujuan untuk mengetahui dampak negatif penggunaan smartphone pada anak, faktor penyebab timbulnya dampak negatif tersebut, serta upaya meminimalisir timbulnya dampak negatif dari penggunaan smartphone pada anak. Penelitian ini menggunakan metode penelitian kualitatif dengan jenis penelitian studi kasus. Hasil penelitian ini menjelaskan bahwa dampak negatif dari penggunaan smartphone yaitu: (1) kecanduan bermain smartphone, (2) menurunnya kedisiplinan siswa, (3) siswa menjadi sering berbohong, (4) lambat dalam  menerima pembelajaran, dan (5) mempengaruhi perilaku siswa. Faktor yang menyebabkan timbulnya dampak negatif tersebut yaitu: (1) kurangnya pengawasan, pendampingan, dan pembatasan penggunaan smartphone dari orangtua, (2) orangtua selalu menuruti segala keinginan siswa, (3) kecanduan game online, dan (4) pengaruh dari lingkungan bermain siswa. Upaya yang telah dilakukan untuk meminimalisir timbulnya dampak negatif yaitu: (1) guru memberikan jadwal pembelajaran daring yang jelas, (2) orangtua memberi batasan waktu dalam penggunaan smartphone, dan (3) orangtua memantau aplikasi yang digunakan oleh siswa.
Aggregatibacter actinomycetemcomitans- A periodontopathogen
Authors: B Ashwath , Vadhana D Adline , V Anitha , M Shanmugam
Published: July 2021

is a gram-negative oral pathobiont that is associated with severe form of periodontitis. This bacterium has various virulence factors which enables the bacterium to colonize the oral cavity, invade and evade the host defences. Leukotoxin and cytolethal distending toxin are the important virulence factors that causes periodontal destruction. Periodontal infections with seems to be refractory to conventional therapy and systemic antibiotics. Hence, leukotoxin represents an ideal anti-virulence target and inhibition of its immunosuppressive activity would eliminate the colonization advantage provided to the bacteria by the toxin.

This review provides a comprehensive update of with an emphasis on its virulence factors leukotoxin and cytolethal distending toxin and its role in periodontal destruction and recent developments in the management.
Soft tissue rejuvination by botox in dentistry: A review
Authors: Sachdeva Bharat , Bansal Mansi , Khatri Manish , Puri Komal , Rehan Mohd.
Published: July 2021

In this era, the passion to look beautiful has evolved various new technologies to enhance and improve the physical appearance of people. There are many medical and dental conditions, which do not have complete treatment modalities in conventional ways. Botox is emerging as one such popular treatment to improve the facial appearance. Botox can enhance aesthetics and is used therapeutically in other medical conditions. The Botox is a minimally invasive technique and may prove out to be an attractive alternative to surgery in some cases
The Pivot Roadmap: From Dreams to Reality
Authors: Khoury Fares
Published: July 2021

The objective of this report is to present an actionable programme to bring initial moonshot ideas into fully accomplishable projects, ready to be deployed. It comprises three parts. The first part, namely Section 2, provides a background and development avenues for three broad domains of Caribbean economies, namely electric vehicles, digital transformation, and tourism. The second part breaks down the realisation of moonshot ideas into steps using a comprehensive roadmap, which lays out, in sequential point-by-point form, how to steer the coherent long-term deployment of moonshot ideas into concrete actionable projects. Sections 3.1 (From Dreams to Deployment) and 3.2 (Overview of Sequential Tasks by Stakeholder Category) present this in detail. Finally, in the third part, Sections 3.3 and 3.4 define and illustrate the roadmap of moonshot ideas identified during the PIVOT Event. In elaborating these two sections, key emphasis was put on the tasks to be conducted during the preparedness phase (Phase 2 of the roadmap). The conclusion summarizes all dimensions of the roadmap into three illustrations, one for each domain, depicting all nine moonshots from the PIVOT Event.
A Contribuição da Odontologia no Diagnóstico e Manejo da Síndrome de Sturge-Weber: Relato de dois Casos
Authors: Rodrigues Bruno Teixeira Gonçalves , Nunes Lucas Alberto dos Santos , Almeida Flávia Souza Pereira de Jesus , Freire Nathália De Almeida , Israel Mônica Simões
Published: July 2021

Objetivo: O objetivo deste estudo foi relatar dois casos de pacientes do sexo feminino com diagnóstico de síndrome de Sturge-Weber (SSW), suas principais manifestações clínicas orais e maxilofaciais e tratamento odontológico. Relato de caso: Caso 1. Paciente do sexo feminino, 30 anos, encaminhada à Clínica de Estomatologia da Universidade Estadual do Rio de Janeiro para avaliação de lesão avermelhada difusa no rosto e na boca. Durante o exame clínico, foram detectadas manchas de vinho do porto (MVP) no lado direito da face e descoloração intraoral sugestiva de SSW. Como a paciente não referia sintomas, foi encaminhada a uma equipe de neurologia para investigar alterações no sistema nervoso central (SNC). Caso 2. Uma mulher de 19 anos foi encaminhada para avaliação de um sangramento gengival com duração de 5 meses na mucosa alveolar mandibular e maxilar direita. O exame extraoral mostrou a presença de MVP no lado direito do rosto. Ao exame intraoral, a hiperplasia gengival causou má oclusão, deposição de placa e sangramento grave. O diagnóstico de SSW foi estabelecido devido a esses achados. A paciente foi encaminhada para tratamento periodontal. Conclusão: Dessa forma, é essencial que o dentista tenha conhecimento das manifestações clínicas dessa síndrome, a fim de realizar seu diagnóstico e propor o tratamento correto
ІНВЕСТИЦІЙНІ РІШЕННЯ НА РИНКУ КРИПТОВАЛЮТ ТА ЇХНІЙ ВПЛИВ НА ФІНАНСОВУ БЕЗПЕКУ КРАЇНИ
Authors: Слобода Лариса , Родіонова Евеліна
Published: July 2021

Обгрунтовано вплив інвестиційної складової на фінансову безпеку країни в умовах діджиталізації інвестиційних рішень у період COVID-19, розвинено зміст інвестиційної безпеки з позиції зміни форм інвестиційного капіталу, що раніше спрямовувався в модернізацію виробництва, а сьогодні інвестується в цифрову валюту, дозволяючи швидко отримувати прибуток. Доведено, що такий перелив капіталу створює істотну загрозу фінансовій безпеці країн, а віртуальна форма реалізації інвестиційного потенціалу створює ризики стабільності державних фінансів.

Проведено аналіз тенденцій ринку криптовалют з урахуванням регуляторного аспекту і способів входження приватних інвесторів на ринок віртуальних інвестицій. Визначено перелік загроз фінансовій безпеці країни у сфері реалізації інвестиційних рішень із криптовалютами на основі децентралізованих фінансових платформ. Доведено, що в середньостроковому періоді, крім загрози стрімкого зниження вартості самих активів, це також зумовлює ймовірнсть браку продуктивних інвестицій у реальних сектор національної економіки, зокрема через внутрішні інвестиції громадян країни. Запропоновано взаємовигідну інтеграцію централізованих і децентралізованих фінансів у сфері інвестиційних рішень на основі виведення численних проєктів криптоінфраструктури в легальне поле і надання їм дозволу взаємодіяти з традиційними постачальниками фінансових послуг, здійснювати трансфер інновацій і знань з урахуванням нових цифрових бізнес-моделей.
TRADUÇÃO E ADAPTAÇÃO TRANSCULTURAL DO INSTRUMENTO EVALUATION OF SIDERAIL USAGE
Authors: Cristina Brasil Ferreira Teresa , Ferreira Santana Rosimere , Gomes do Carmo Thalita , Veríssimo de Souza Márcia , Alfradique de Souza Priscilla
Published: July 2021

Objetivo: traduzir e adaptar transculturalmente o instrumento Evaluation of Siderail Usage para a língua portuguesa do Brasil. Método: pesquisa metodológica de tradução e adaptação transcultural de um instrumento em quatro etapas. Resultados: na primeira etapa foram realizadas duas traduções; na segunda, foi realizada uma reunião consensual com duas tradutoras e as autoras do estudo para discutir discrepâncias e gerar uma versão síntese; na terceira etapa, a versão síntese foi retrotraduzida para o inglês por duas tradutoras para se verificar a equivalência com a versão original; e na quarta etapa, um comitê de 25 juízes profissionais da área de saúde analisaram a versão síntese. Os resultados demostraram um Índice de Validade de Conteúdo do instrumento de 0,97 e um Coeficiente de Validade de Conteúdo de 0,93. Conclusão: a tradução e adaptação do instrumento Evaluation of Siderail Usage para a língua portuguesa do Brasil apresentou bons índices de validade do conteúdo.

Descritores: Leito. Quedas. Segurança do Paciente. Restrição Física
IMPACTO DA SUPERVISÃO CLÍNICA EM ENFERMAGEM NA AVALIAÇÃO E INTERVENÇÃO NO AUTOCUIDADO
Authors: Rocha Inês , Carvalho António Luís , Pinto Cristina Barroso , Rodrigues Agostinho , Rocha Vânia
Published: July 2021

Objetivo: avaliar concordância, relacionada ao grau de dependência no autocuidado, entre pesquisador, enfermeiros e prontuários antes e após implementação do Modelo SafeCare e avaliar as intervenções de enfermagem relativas ao autocuidado prescritas, antes e após implementação do Modelo SafeCare. Método: estudo quase experimental. Para coleta dos dados, em 2017 e 2019, utilizou-se instrumento de avaliação do autocuidado antes e após implementação do Modelo de supervisão clínica em enfermagem (SafeCare). Resultados: participaram 216 pacientes. A concordância entre pesquisador e enfermeiros aumentou do pré-teste para o pós-teste nos autocuidados higiene (k=0,79), alimentar-se (k=0,73) e posicionar-se (k=0,79). Nas intervenções de enfermagem, verificou-se existência de concordância entre todos os avaliadores no pós-teste, ao contrário do pré-teste em que não existiu concordância na intervenção “incentivar o autocuidado: higiene” entre pesquisador e enfermeiros/prontuários. Conclusão: a concordância entre formulários preenchidos pelos grupos individualmente aumentou significativamente na maioria dos autocuidados avaliados e das intervenções prescritas após implementação do Modelo SafeCare.

Descritores: Enfermagem. Supervisão de Enfermagem. Autocuidado. Diagnóstico de Enfermagem. Qualidade da Assistência à Saúde.
Epigenetic Modifications of Host Genes Induced by Bacterial Infection
Authors: Parhamfar Maryam , Rezaei Marzieh
Published: July 2021

Introduction: Epigenetic mechanisms regulate expression of the genome to generate various cell types during development or coordinate cellular responses to external stimulus. While epigenetics is of fundamental importance in eukaryotes, it plays a different role in bacteria. This article uncovers the most important recent data on how bacteria can alter epigenetic marks and can also contribute to and/or result to various diseases. In this review article, Sciencedirect, PubMed, Scopus, Google Scholar databases were used for finding the relevant studies. Research has shown that bacteria can affect the chromatin structure and transcriptional program of host cells by influencing diverse epigenetic factors (i.e., histone modifications, DNA methylation, chromatin-associated complexes, and RNA splicing factors). Therefore, bacterial-induced epigenetic deregulations may affect host cell function either to host defense or to allow pathogen persistence. Hence, pathogenic bacteria can be considered as potential epimutagens able to reshape the epigenome that their effects might leading to cellular dysfunctions, which influenced immunity and might be at the origin of unexplained diseases and this caused presentation or contributed to the development of pathological changes.
Conclusion: Epigenetic modifications during development and in response to environmental factors contribute to phenotypic variability and susceptibility to a number of diseases, including infectious diseases, cancers, metabolic and autoimmune disorders.
Comparative study of pulse oximetry, physical examination and echocardiography results in the diagnosis of congenital heart defects in neonates in the first 24 hours of life
Authors: Amiri Simkouii Fatemeh , Jamshidi Maryam , Behjati Ardakani Mostafa , Toosi Farzaneh , Alipour Mohammad Reza , Namayandeh Seyedeh Mahdieh
Published: July 2021

Introduction: Congenital heart disease is the most common congenital anomaly. About 50% of Neonates with congenital heart disease are asymptomatic in the first few days of life and are not diagnosed on initial examination. Pulse oximetry is a non-invasive method that can show the percentage of oxygen saturation in the blood and congenital heart disease.
Methods: This was a descriptive cross-sectional study and the sampling method was census. Echocardiography was performed for all neonates with spo2 less than 95% and also neonates who were diagnosed with a problem by a cardiologist. After collecting the samples, the results obtained from pulse oximetry, physical examination and echocardiography were analyzed using SPSS software version 16 and statistical tests of Kolmogorov-Smirnov normality and Spearman correlation. Was investigated.
Results: In pulse oximetry evaluation, 1.9% of neonates had spo2 (arterial oxygen saturation) less than 95%. 1.7% of neonates had heart problems in physical examination and 2.12% of neonates had heart problems in echocardiography. The highest correlation between pulse oximetry and echocardiography was 0.917.
Conclusion: Considering the diagnostic importance of congenital heart diseases and their impact on a person's life, it is recommended that pulse oximetry be added to physical examinations at birth as a screening method for heart disease.
VERBAL AGGRESSION IN THE COMMENTS OF THE SOCIAL NETWORK FACEBOOK
Authors: Malysheva Mariia
Published: July 2021

The article is devoted to the study of verbal aggression in the Ukrainian-language network discourse. The aim of the study was to analyze the manifestations of verbal aggression in the comments of Facebook users, which involved solving the following tasks: to define the concept of verbal aggression, to analyze comments on social network as a special genre of network discourse, to identify language markers of verbal aggression in comments. The comments of Ukrainian-speaking users of the social network Facebook were analyzed and the language means of realizing verbal aggression were singled out. The main concepts of researchers on the concept of verbal aggression and verbal aggression are interpreted as conflicting behavior of speakers, expressed through language, among which are analyzed lexical, morphological, syntactic and graphic.
FUNCTIONING OF TOKEN-QUANTITATIVES OF THE THEMATIC GROUP WATER OBJECTS WITH SEMANTICS OF MULTIPLICITY IN THE STRUCTURE OF POETIC DISCOURSE
Authors: Semenenko Oleksandra
Published: July 2021

The article analyzes the structural and semantic features of the functioning in the poetic speech of the token-quantitatives of the thematic group of water objects with metaphorized meaning ‘many people, something’ in the indecomposable quantitative noun phrases. Peculiarities of interaction of paradigmatic and syntagmatic aspects of functioning of token-quantitatives of the function of indefinite quantification of thematic group of water objects, establishment of semantic environment of these indefinite- quantitative quantitatives, ie their realized semantic valence in combination with actualizers of this value It is proved that contextually carriers of quantitative semantics can become noun tokens ponds, floodplain, vortex. They do not have codified LSV to denote a large number, but under certain discursive conditions acquire such an ability. By frequency of use belong to the periphery.
Postgraduate Internationalisation in Brazil
Authors: McManus Concepta , Baeta Neves Abilio Afonso , Oliveira Cyntia , De Oliveira Castro Henrique
Published: July 2021

Understanding the current state of the Internationalisation of postgraduate courses in Brazil was essential to serve as a basis for constructing effective policies in funding agencies. It also helps to understand the capacity of the higher education institution to carry out more effective strategic planning and internationalisation plans. This study looks at replies to a Brazilian national funding agency (CAPES) questionnaire on Internationalisation within Higher Education Institutes in Brazil, based on the postgraduate experience. Results showed that Internationalisation is based on mobility with little comprehensive thinking on its role towards academic achievement within the Postgraduate Programs realities, beyond the mobile individual.  English language skills need to be improved. While most institutions have offices that treat this theme, they lack an active engagement with the postgraduate programs and strategic planning, seen as vital for almost all institutions.  Resources are necessary to build infrastructure and capacitate lecturers and staff to this end.
CEO Capability and CEO Arrogance
Authors: Magdalena Renna , Dananjaya Yanuar
Published: July 2021

This study aims to see the effect of the CEO Capabilities and CEO Arrogance to fraudulent financial statements indication. The study used a sample of all manufacturing companies from 2017 to 2019. In accordance with the sample selection, there are 162 manufacturing companies that meet the sample criteria. In this study using multiple linear regression test. This study uses secondary data for the 2017-2019 annual report.

Based on the results that have been tested, CEO capability as a respected party (CEO Age), CEO capability as the person who knows the most about the company (CEO Tenure) and CEO arrogance as a person who has political connections (CEO Political Connection) have an influence on the indication of fraudulent financial statements. Furthermore, the hypothesis of CEO Capability in Accounting/finance knowledge (CEO Education), CEO arrogance in the form of narcissism (CEO PIC) and CEO arrogance as company founder (Founder CEO) have no influence on indications of fraudulent financial statements.
Estrategia de restauración ambiental en la cuenca sur del río Manzanares de Madrid
Authors:   Universidad Rey Juan Carlos, Ajuriaguerra Escudero Miguel Ángel , Ramírez Saiz Alba ,   Universidad Rey Juan Carlos
Published: July 2021

La cuenca sur del río Manzanares en Madrid experimenta un proceso de restauración ambiental englobado dentro del proyecto Parque Lineal. Este está suponiendo una mejora sustancial en la calidad de vida de los ciudadanos próximos al río de los Distritos de Usera y Villaverde. No obstante, estas mejoras se contraponen con la sensación de abandono institucional que experimentan los vecinos de los barrios interiores, viéndose alejados de las mejoras de regeneración ambiental del Manzanares. El objetivo de este artículo es identificar las problemáticas principales relacionadas con la accesibilidad, la usabilidad y la salubridad del Parque Lineal. Además, se exponen las acciones necesarias para alcanzar una propuesta estratégica integral que favorezca la consolidación del distrito mediante elementos de infraestructura verde que faciliten las relaciones de movilidad y usabilidad entre las áreas interiores y el perímetro de la restauración ambiental del Manzanares.
Influencias asiáticas en la búsqueda del confort en el periodo colonial chileno: de la alfombra al estrado
Authors: Baros Townsend Mauricio Alejandro
Published: July 2021

En las sobrias casas coloniales chilenas e hispanoamericanas se destacaba una pieza de mobiliario de uso diario: el estrado, un objeto que tendría su origen en la textilatría que surgió tempranamente en el Asia Central y en la cultura islámica y cuyo mayor exponente fue la alfombra, la cual realizó un camino al mundo europeo a través del comercio flamenco. Este trabajo pretende demostrar el origen oriental del estrado, a través de su tránsito asiático y luego europeo hasta hacer su arribo en América, y también destacar el rol social que adquirió al constituirse en un mobiliario esencialmente femenino dentro del espacio de la casa colonial chilena.
Metadiscourse in Academic Written and Spoken English: A Comparative Corpus-Based Inquiry
Authors: Vasheghani Farahani Mehrdad
Published: July 2021

This paper reports on a comparative study performed in the field of Corpus Linguistics. The objective of the research was to analyze the distributional pattern of interactive and interactional metadiscourse features in two modes of academic spoken and written English. For this reason, a list of metadiscourse characteristics was gathered. By using the Sketch engine software, all the words were scrutinized in the corpus and their concordance lines were analyzed one by one in both corpora (British Academic Written English Corpus and British Academic Spoken English Corpus). As the data can show, in both corpora, the general propensity of the authors was towards the interactive metadiscourse features. In addition, in the written corpus, the transitions and endophoric markers were used more often; while in the spoken, endophoric markers and transitions were the most frequently applied metadiscourse features. In the interactional metadiscourse features, hedges and self-mentions were the most frequent in the written form; whereas in the spoken, self-mentions and boosters were used moe often.
Word-final /ɔ̃/ in Greater Poland Polish: A Cumulative Context Effect?
Authors: Kaźmierski Kamil , Szlandrowicz Marta
Published: July 2021

An empirical corpus-based study of the likelihood of realizing the Polish nasal vowel /ɔ̃/ word-finally as [ɔm] (i.e. of 'nasal stopping') is presented. The goal was to verify whether the phenomenon exhibits a cumulative context effect, with words typically occurring in an environment favoring a particular phonetic variant showing higher rates of that variant regardless of environment. The results show that nasal stopping is more likely before stop-initial words than before words beginning in other sounds, if there is no intervening pause. Results with regard to the hypothesis that words typically followed by stops will show higher likelihood of nasal stopping, however, remain inconclusive.
Written Languaging and Engagement with Written Corrective Feedback: The Results of Reflective Teaching
Authors: Falhasiri Mohammad
Published: July 2021

For corrective feedback (CF) to contribute to second language (L2) development, some cognitive processes need to be completed. Learners need to notice and comprehend the CF, reflect on and deeply process it, and finally integrate it into their interlanguage (Gass, 1997). Written languaging (WL), which requires learners to explicitly explain to themselves why they have received CF, has been proposed as a technique which can stimulate deep cognitive processing of the written CF. In an effort to improve learners’ writing accuracy, I adopted WL, whereby upon receiving online direct corrections, learners typed their selfexplanations regarding the underlying reasons for their writing mistakes. Then, I engaged in systematic reflection and journaling during a 10-week semester to critically analyze the affordances and limitations of WL. The conclusion, drawn from my perceptions of the usefulness of WL originating from my journal writing, is that WL has the potential to not only facilitate learning for students but also can provide teachers with a rich description of learners’ cognitive and affective engagement with CF. Some recommendations are made for better implementation of this instructional technique.  

Pour que la rétroaction corrective (RC) contribue au développement de la langue seconde (L2), des processus cognitifs doivent se produire. Les apprenants doivent remarquer et comprendre la RC, y réfléchir, la traiter profondément et pour finir, l’intégrer dans leur interlangue (Gass, 1997). La mise en langue écrite (MLE), qui exige des apprenants qu’ils s’expliquent à eux-mêmes de façon explicite pourquoi ils ont reçu de la RC, a été proposée comme une technique qui peut stimuler le traitement cognitif profond de la RC écrite. Dans le but d’améliorer la précision de la rédaction des apprenants, j’ai adopté la MLE, où, lorsqu’ils recevaient les corrections directes en ligne, les apprenants tapaient leurs propres explications sur les raisons pour lesquelles ils avaient commis des erreurs écrites. Ensuite, je me suis employé à réfléchir systématiquement et à tenir un journal pendant les 10 semaines que durait le semestre, afin d’analyser de façon critique les opportunités et les limitations de la MLE. La conclusion, tirée de mes perceptions de l’utilité de la MLE puisées dans mon journal, est que la MLE a non seulement le potentiel de faciliter l’apprentissage des apprenants, mais peut aussi fournir aux enseignants une riche description de l’engagement cognitif et affectif des apprenants eu égard à la RC. Des recommandations sont faites pour une meilleure mise en œuvre de cette technique d’enseignement.
Ingreso de aerolíneas low cost al mercado peruano y su impacto en las aerolíneas comerciales tradicionales de rutas nacionales, años 2015-2018
Authors:   , Camasca Jeremías Giovanna Arsenia , Medina Molina María Jimena
Published: July 2021

Esta investigación titulada “Ingreso de aerolíneas low cost al mercado peruano y su impacto en las aerolíneas comerciales tradicionales de rutas nacionales, años 2015-2018” tiene como objetivo analizar el efecto de las aerolíneas low cost con respecto a las tradicionales. Actualmente, estas últimas están ingresando al Perú con varias rutas nacionales, lo cual tiene como finalidad obtener una mayor participación en el mercado. Sin embargo, las aerolíneas tradicionales se mantienen en constantes cambios con su modelo de negocio para seguir compitiendo. La investigación se divide en cinco capítulos: En el Capítulo I se presenta el marco teórico y se explican los conceptos básicos, tales como las estructuras de mercado; las estrategias de fijación de precios; conceptos aeronáuticos; concepto de low cost; principales aerolíneas del Perú; ingreso de low cost (caso Perú) y costeo y tarifas de low cost. En el Capítulo II del plan de investigación se formula la problemática de la investigación, hipótesis y objetivos. En el Capítulo III que corresponde a la metodología de investigación, se detallan los tipos de investigación e instrumentos a utilizar. En el Capítulo IV del desarrollo de la investigación, se analiza la información cualitativa y cuantitativa. En el Capítulo V se presentan los análisis de resultados y se realiza el análisis de los instrumentos, concluyendo con la validación de la hipótesis general y específicas basados en los resultados obtenidos del análisis de correlación y entrevistas a especialistas. Finalmente, las conclusiones para todos aquellos que deseen analizar el impacto de las aerolíneas low cost.
Modelo de aseguramiento de calidad para los procesos de desarrollo de software de las Pymes
Authors:   , Aranibar Villegas Bryan Christhofer , Mendez Cartolin Johanna Liseth
Published: July 2021

Actualmente las Pequeñas y Medianas Empresas (Pymes) son de gran importancia en la economía, representando más del 90 % del total de empresas, generando entre el 60 y 70 por ciento del empleo a nivel mundial (ONU, 2017), y en particular en la industria software. Hoy en día, el uso de software es un recurso indispensable, sin embargo, todavía siguen subsistiendo grandes problemas durante su proceso de desarrollo debido al poco enfoque que se le da a la calidad durante la elaboración de un software. Esto se debe a que los modelos de calidad de procesos en este sector fueron orientadas a grandes empresas, por lo que adaptarlas a las pymes resulta difícil, debido a que conlleva una gran inversión en dinero, tiempo y recursos (Grados, 2015), que lo hace inaccesible. Como propuesta de solución se propone un modelo de aseguramiento de calidad para ayudar a las pymes a mejorar sus procesos de desarrollo de software, basado en el ciclo de Deming para la mejora continua y en las buenas prácticas del CMMI y la ISO 12207. El modelo propuesto se adapta a cualquier metodología de desarrollo y es fácil de implementar. El modelo fue probado en un proyecto dentro de una Pyme desarrolladora de software cuyos resultados fueron una mejor estabilidad y definición de requerimientos ya que estos no sufrieron modificaciones ni mostraban ambigüedad, una mejor construcción de software ya que las funcionalidades fueron probadas con éxito, mayor cobertura y madurez de pruebas y una menor densidad de defectos.