bluuebunny/crossref_metadata_2025 huggingface dataset:
Medicinal Species of The Genus Croton (Euphorbiaceae): a Worldwide View on the Dynamics and Evolution of Scientific Production
Authors: Nogueira Micaella Lima , Fava Wellington Santos , Correia Jonas Benevides , De Araújo Rildo Vieira , Martins Romildo Camargo , Dos Santos Adriana Bilar Chaquime , Magalhães Filho Fernando Jorge Corrêa , Da Costa Reginaldo Brito
Published: January 2024

Objective: the present study aimed to gather scientific information on a worldwide level about publications on the Croton genus, with the identification of the main medicinal species, their bioactive compounds and medicinal uses, using information published in journals and different and complementary references in the area of applied botany, supporting research with species of this genus.
 
Theoretical framework: Croton genus is one of the largest of the Euphorbiaceae family and contains approximately 1,300 species, many of which used in traditional medicine for treating stomach disease, abscess, inflammation, and malaria. The use of bibliometric surveys has been developing for years, grouping information and aiding decision-making in all areas, especially human health and environmental sciences.
 
Method: Web of Science platform was used to obtain data, we compiled the documents found considering various information. For the analysis, the Bibliometrix package from the RStudio software was used, as well as the IRAMUTEQ software.
 
Results and conclusion: mapping of scientific production recorded 64 species in the 354 papers found, in investigation or confirmation of medicinal potential. The main bioactivities examined were the anti-inflammatory, antimicrobial, antioxidant, antinociceptive, anticancer, and antimalaria actions.
 
Research implications: Brazil stood out in the following aspects: number of publications, collaborations, and affiliations with active research about the genus, which can be attributed to the genus’ degree of endemism in this country.
Originality/value: this unprecedented study constitutes relevant support for future research involving the bioactive potential of new Croton species and even other plants of popular medicinal use.
Performance of Common Bean Cultivated in Succession to Cover Crops
Authors: Araújo Érica de Oliveira , Freitas Diogo de Souza , Catânio Jose Vanor Felini , Viana Filho Luís Antônio Bento , Guimarães Emily Gomes
Published: January 2024

Purpose: The present research aims to evaluate the biomass production and nutrient uptake by different cover crops, as well as to verify the effects of straw on bean productivity.
 
Method: The experimental design was completely randomized, consisting of sowing beans on straw four cover crops (Crotalaria ochroleuca, Pigeon pea, Mucuna gray and Lab-lab) + control, with five replications.
 
Results and conclusion: The Pigeon pea species has great potential for dry matter production and ability to absorb and accumulate phosphorus in the leaves in full bloom. The straw of the species Crotalaria ochroleuca, Pigeon pea and Mucuna cinza contributed significantly to the productivity of common bean cultivated in succession, as well as represent an alternative to reduce the dependence on synthetic fertilizers and increase the sustainability of agricultural systems.
 
Implications of the research: The search for maintaining or increasing crop production through the adoption of conservation practices with emphasis on the cultivation of cover crop species is emphasized as an efficient strategy for nutrient cycling, improving soil health and increasing productivity with sustainability assumptions.
 
Originality/value: The results obtained in this study are relevant to the scientific community, contributing to the training of educators and development of students, especially in the area of agricultural and environmental sciences, serving as a scientific basis for the regional technological process.
Specialized Educational Service as a Means of Enhancementing the Right to Access and Permanence of People With Disabilities at School
Authors: Araujo Anágila Alves Ferreira
Published: January 2024

Purpose: Within this theme, the objective was to analyze the history of special education, going from the distant past to the present, presenting the evolution of this type of teaching, its perspectives and interpretations, as well as identifying the main legal norms that discuss rights of students with disabilities.
 
Theoretical background: It concerns the school inclusion of students with disabilities based on the insertion of the specialized educational service room in the school environment.
 
Methodology: It is inferred that a qualitative study was developed using documentary and bibliographical research.
 
Results and conclusion: Through this research, it was concluded that individuals with disabilities are being gradually inserted into school spaces thanks to actions promoted by the State, however there are still many actions to be done so that inclusion school is fully manifested.
 
Research implications: The study advances in verifying Specialized Educational Assistance as a fundamental tool to realize the right to inclusive education, ensuring that people with disabilities have access, participation and effective permanence in the school environment.
 
Originality/value: It is expected that this work can bring great contributions to the topic covered, considering that the subject is little discussed despite its great relevance to the area of law, education and society in general.
Geodiversity Hotspots in Itabirito
Authors: Leite Frederico Arthur Souza , Castro Paulo de Tarso de Amorim , Da Silva Rodrigo Florencio
Published: January 2024

Objectives: The objective of this work is to establish the Geodiversity Index for the municipality of Itabirito. It is expected to identify Geodiversity Hotspots, priority areas for conservation.
 
Theoretical Framework: The literature review addressed geological resources, geodiversity and geoconservation of the Iron Quadrangle. Currently, the relevance of geodiversity is growing among scientific journals, research groups and government programs.
 
Method: As a methodology, based on a bibliographical review of scientific works to determine the Geodiversity Index, and collection of secondary data on the physical environment of Itabirito, a grid polygon was created in the QGIS software, measuring 250x250m. To define the degree of influence of each of the variables considered, the Analytic Hierarchy Process method was used. Next, maps were created for each of the six variables as well as for the Geodiversity Index.
 
Results and conclusion: The result of the Analytic Hierarchy Process method obtained a consistency rate of 3.7% to determine the weights of each adopted variable. Then the equation can be established to determine the Itabirito Geodiversity Index.
 
Implications of the research: Exactly in areas that presented high to very high IGD, geodiversity hotspots can be determined. The mapping and analyzes carried out confirm that the municipality of Itabirito has regions considered Geodiversity Hotspots.
 
Originality/Value: This work contributes significantly to the knowledge of the geodiversity of the municipality of Itabirito. The establishment of the IGD for the Itabirito territory is relevant to guide the creation of mechanisms to promote geoconservation and geotourism.
UTICAJ SPOLJAŠNJIH I UNUTRAŠNJIH FAKTORA MOTIVACIJE NA ZADOVOLJSTVO POSLOM
Authors: Ignjatović Zorana
Published: January 2024

Predmet istraživanja ovog rada jeste analiza uticaja unutrašnjih i spoljašnjih faktora motivacije na zadovoljstvo poslom. Pored toga, prikazan je značajna motivacija odnosno uloga motivacije u poslovnom okruženju kao i teorije motivacije. Značajan deo rada posvećen je stilovima rukovođenja i njihovom značaju i utiču na zaposlene i motivaciju. Definisano je šta je zadovoljstvo poslom i koji su to faktori koji imaju uticaj na zadovoljstvo poslom.
ANALIZA I UNAPREĐENJE SKLADIŠTA I PROCESA SKLADIŠTENJA U KOMPANIJI MARBO PRODUCT DOO
Authors: Vajagić Nemanja
Published: January 2024

U radu su obrađene teorijske osnove iz oblasti logistike, skladišta, skladišnog poslovanja i sistema za upravljanje i unapređenje skladištem, pri čemu je fokus bio na kompaniji Marbo Product doo
PUTOVANJE KROZ NIGDINU
Authors: Stojadinović Nikola
Published: January 2024

Master umetnički rad Putovanje kroz nigdinu ispituje i istražuje fenomen putovanja kroz nepoznat, neizvestan prostor. Govoreći o putovanju ovde ne govorimo o unapred planiranom putovanju kroz neki fizički prostor ili stvarni svet, ovde govorimo o oniričkom putovanju, putovanju u unutrašnji svet samog putnika - putnika sanjara. Ovde se radi, dakle, o oniričkom iskustvu - budnom sanjarenju, zadiranju u užareno središte bića. Međutim, kako i sami snovi svoje uporište imaju u stvarnosti, tako je i ovo putovanje prožeto nitima stvarnosti. Ishod istraživanja je umetničko delo scenskog dizajna, višemedijska prostorna instalacija realizovana u prostoru kompleksa stare Ranžirne stanice, gde se intmini, unutrašnji svet snova konačno sudario sa stvarnim, opipljivim svetom.
ENHANCING INTRUSION DETECTION SYSTEM ON NODEMCU WITH ENSEMBLE VOTING
Authors: Alamsyah Nur
Published: January 2024

As part of the Internet, a NodeMCU becomes a vulnerability to cyber-attack, so the intrusion detection system (IDS) against cyber-attack on the NodeMCU becomes a poignant research challenge. Several studies have applied several machine learning techniques for IDS on NodeMCU; however, there is a research opportunity to improve the performance of existing models. This research aims to increase the IDS performance on NodeMCU with ensemble voting. We hypothesize the realization of how the implementation of an IDS in NodeMCU. Then we obtain and observe a dataset from Kaggle. The dataset comprises five attacks: misconfiguration, DDoS, probe, scanning, and MiTM. Then we design the detection with ensemble voting consisting of a decision tree and a random forest. We benchmark our proposed solution with decision trees and random forest performance. This study uses several test metrics, including , , , and .The test results show that the decision tree has better Precision in predicting misconfiguration attacks and scan attacks than random forests. On the other hand, the random forest has better in predicting normal data, DDoS attacks, probe attacks, and MiTM attacks. In terms of , ensemble voting has the best performance, which is , compared to the decision tree and random forest, which are and , respectively. We conclude that by assembling a decision tree in the random forest with ensemble voting, random forest performance can improve.
أثر التصنيع الهجين في تصميم وتحسين عمليات الانتاج من خلال تبني سلسلة التجهيز الهجينة: دراسة استطلاعية لآراء عينة من العاملين في معمل اسمنت بادوش- التوسيع
Authors: حاجم ياسر مولود , محمود عبدالله عبدالله
Published: January 2024

هدفت الدراسة بصورة اساسية إلى تحديد تأثير التصنيع الهجين بأبعاده الفرعية في تصميم وتحسين عمليات الإنتاج من خلال تبني سلسلة التجهيز الهجينة، على مستوى معمل سمنت بادوش التوسيع، وتتجسد مشكلة الدراسة بإثارة مجموعة من الأسئلة أهمها، هل تتبنى إدارة المعمل المبحوث أبعاد المتغير المستقل (التصنيع الهجين) وأبعاد المتغير التابع (تصميم وتحسين عمليات الانتاج)؟ ولغرض تحقيق أهداف الدراسة والإجابة عن أسئلتها، أعتمد الباحث المنهج الوصفي وفي ضوئه تم تصميم الاستبانة بوصفها أداة رئيسة في جمع البيانات، إذ تم توزيع (314) استبانة على عينة من العاملين في معمل سمنت بادوش، وبعد المعالجة الإحصائية للبيانات، توصلت الدراسة إلى عدد من النتائج كان من أهمها إن اهتمام وسعي ادارة المعمل عينة الدراسة بتعزيز تأثير التصنيع الهجين في تصميم عمليات الإنتاج من خلال تبني سلسلة التجهيز الهجينة على المستوى الميداني من شأنه أن يحسن مستوى ابعاد تصميم وتحسين عمليات الإنتاج بصورة أفضل، فضلا عن أهم التوصيات والمتمثلة بحرص إدارة المعمل على العمل باستراتيجية عدم التلاقي (التأجيل)، للفصل بين العمليات الانتاجية عن طريق تأخير بعض النشاطات الإنتاجية المهمة لحين استلام طلبات الزبائن، ثم اكمال عملية الإنتاج، بهدف تقليل المخزون والإسراع بتلبية طلبات الزبائن.
دور الشفافية الاستراتيجية في تعزيز الصحة التنظيمية: دراسة تحليلية لعدد من الكليات في جامعة تكريت
Authors: محمد صباح صابر , حسين احمد على
Published: January 2024

هدفت الدراسة إلى تحليل العلاقة بين الصحة التنظيمية والشفافية الاستراتيجية في عدد من كليات جامعة تكريت، ولتحقيق هدف الدراسة والإجابة عن أسئلة مشكلتها تم استخدام المنهج الوصفي التحليلي والاستبانة كأداة رئيسية للدراسة في جمع البيانات وتحليلها، وتمثلت عينة الدراسة  بالقيادات الادارية والتدريسيين كذلك الموظفين العاملين في كليات ميدان الدراسة والمتمثلة بكلية(الهندسة، الإدارة والاقتصاد، كلية التربية للعلوم الصرفة، كلية التربية، كلية الآداب، كلية العلوم السياسية، كلية التربية البدنية وعلوم الرياضة وكلية العلوم الإسلامية.           وقام الباحث بتوزيع 250 استبانة على القيادات الادارية والتدريسيين والموظفين للميدان المبحوث، وكان المسترد منها 182 استبانة جميعها صالحة للتحليل، وبنسبة 72.8٪، وتم تحليل البيانات باستخدام البرنامج الإحصائي (SPSS-Ver-22)، لاستخراج النتائج الإحصائية.    وتوصلت الدراسة إلى مجموعة من الاستنتاجات أهمها: أظهرت نتائج اختبار الفرضيات وجود علاقة ارتباط وتأثير ذات دلالة إحصائية بين المتغيرين (الشفافية الاستراتيجية والصحة التنظيمية)، وبين كل بُعد من أبعاد الشفافية الاستراتيجية على الصحة التنظيمية، كما قدمت الدراسة عددًا من التوصيات من أهمها: توصي الدراسة الاهتمام بإرساء ثقافة الشفافية الاستراتيجية في جامعة تكريت، وخلق بيئة داعمة لها قائمة على أساس الوضوح والتعاون، من خلال مشاركة المعلومات للعاملين والأفكار التي تساهم في بناء الشفافية الاستراتيجية.
دور استراتيجيات الموارد البشرية في تحقيق الرضا الوظيفي بتوسيط الثقافة التنظيمية: دراسة استطلاعية لآراء عينة من العاملين في دائرة صحة صلاح الدين
Authors: إبراهيم مقداد فاضل , يونس جومانة
Published: January 2024

هدفت الدراسة إلى التعرف على تطبيق استراتيجيات الموارد البشرية من وجهة نظر العاملين في دائرة صحة صلاح الدين والتعرف على تطبيق الرضا الوظيفي للعاملين. تم استخدام المنهج الوصفي التحليلي في تحليل البيانات واختبار الفرضيات، وتقييم دور استراتيجيات الموارد البشرية في تحقيق الرضا الوظيفي بتوسيط الثقافة التنظيمية، حيث تم استخدام استبانة لجمع البيانات، وكان مجتمع الدراسة جميع العاملين في دائرة صحة صلاح الدين وتم اختيار عينة عشوائية متمثلة بــ (90) شخص من العاملين في الدائرة المبحوثة.
          توصلت الدراسة إلى نتائج مهمة وكان أهمها، وجود أثر ذو دلالة إحصائية عند مستوى الدلالة (a≤0.05) لاستراتيجيات الموارد البشرية والتي تتمثل بـــــ (استراتيجية تخطيط الموارد البشرية، استراتيجية التوظيف، استراتيجية التدريب والتطوير) على الرضا الوظيفي والثقافة التنظيمية في دائرة صحة صلاح الدين.
دور بعض متغيرات السياسة النقدية في استقرار سعر الصرف في العراق للمدة (2004-2021)
Authors: جياد سرى محمد , حمد حسين عبد الرزاق
Published: January 2024

هدفت الدراسة إلى تحليل أثر بعض متغيرات السياسة النقدية (عرض النقد الواسع (M2) ومبيعات نافذة العملة الاجنبية) على سعر صرف الدينار العراقي، خلال المدة (2004-2021) وبالاعتماد على منهجية التحليل القياسي.
          وتوصلت الدراسة إلى مجموعة من النتائج أهمها أن المعروض النقدي (عرض النقد الواسع) كان متزايداً خلال مدة الدراسة نتيجة لزيادة الانفاق الحكومة من جهة وضعف سياسة التعقيم النقدي من قبل السلطات النقدية من جهة أخرى وبالتالي فأن استمرار زيادة المعروض النقدي انعكس سلبياً في خفض قيمة الدينار العراقي من جهة ورفع معدلات التضخم من جهة اخرى، وإن سعر صرف الدينار العراقي يتأثر بجملة من العوامل أهمها؛ التقلبات الحاصلة في الايرادات النفطية من الدولار، فضلاً عن التقلبات الحاصلة في مبيعات نافذة العملة الأجنبية والتي عادة ما تنخفض بسبب انخفاض الايرادات النفطية من الدولار، فضلاً عن تغيرات سعر الصرف الرسمي المتبع من قبل البنك المركزي العراقي.
          فيما أوصت الدراسة بأنه يجب على السلطات النقدية (البنك المركزي العراقي) اتباع سياسة نقدية معقمة للزيادة الحاصلة في مناسيب السيولة النقدية من أجل الحفاظ على العملة المحلية وتجنت حدوث حالات التضخم غير المرغوب فيها والتي تنعكس سلبياً على العراق من الناحية الاقتصادية والاجتماعية.
أثر تطور القطاع المصرفي على النمو الاقتصادي في العراق للمدة (2004-2021)
Authors: سلو جاسم أحمد , علي نزير ياسين
Published: January 2024

يعد القطاع المصرفي من أهم العوامل التي تؤثر على النمو الاقتصادي والتنمية المستدامة في أي بلد، حيث يقوم بتوفير التمويل والخدمات المالية للقطاعات الإنتاجية والاستهلاكية، ويسهم في تحقيق الاستقرار المالي والنقدي. وفي ظل التحديات التي تواجه العراق في مجالات مختلفة فقد احتلت البنوك والمؤسسات المالية المركز الرئيسي في النظام المالي العراقي. لذلك، يتجاوز أهمية التطور المصرفي إلى الأبعاد الاقتصادية الأوسع، حيث يعتبر قطاع المصارف عاملاً أساسياً في تحقيق الاستقرار الاقتصادي وتعزيز النمو المستدام، لكن على الرغم من ذلك يعاني القطاع المصرفي في العراق من عدة مشكلات وضعفات تحول دون تحقيق إمكاناته الكاملة، وتشمل هذه المشكلات قلة التغطية المصرفية للسكان، وضعف التمويل للمشاريع الصغيرة والمتوسطة، وانخفاض مستوى التطور التكنولوجي والابتكار في الخدمات المصرفية. وتهدف هذه الدراسة إلى قياس أثر تطور القطاع المصرفي على النمو الاقتصادي في العراق خلال الفترة من 2004 إلى 2021 باستخدام نموذج ARDL، وتحديد أهم التحديات التي تواجه تطور هذا القطاع، وإبداء بعض التوصيات لتحسين أدائه.
دور ممارسات إدارة الاحتواء العالي في الحد من التنمر في مكان العمل (دراسة تحليلية لآراء عينة من العاملين في مديرية صحة صلاح الدين)
Authors: عبد الكريم علي أحسان , عبد الله انيس احمد
Published: January 2024

أهم الأهداف: هدفت الدراسة الحالية إلى التعرف على دور ممارسات إدارة الاحتواء العالي في الحد من ظاهرة التنمر في مكان العمل في مديرية صحة صلاح الدين.
منهج البحث: تبنت الدراسة المنهج (الوصفي التحليلي) والذي يعد أحد أهم مناهج البحث العلمي وأكثرها شيوعا، ويعود السبب في ذلك إلى المرونة والشمولية البحثية الكبيرة التي يوفرها هذا المنهج، إذ إنه يمكن الباحث من تشخيص ودراسة الواقع على نحو أكثر دقة.
أدوات جمع البيانات: استخدمت الدراسة الحالية أداة (الاستبانة) كـــأداة رئيسية لجمــــع البيانات والمعلومات حول مشـكلة الدراسة.
عينة الدراسة: استخدمت الدراسة الحالية (المدراء والعاملين) في مديرية صحة صلاح الدين، إذ تم توزيع (250) استمارة على العينة في المديرية المبحوثة.
الأدوات الإحصائية المستخدمة: تم اعتماد اثنين من البرامج الاحصائية (SPSS V22) و(AMOS V20) ذات المعولية في التطبيق تم إجراء التحليل الإحصائي على البيانات التي تم جمعها وفق استمارة الاستبيان وحسب الأساليب الإحصائية الملائمة لكل اختبار.
اهم النتائج: اتضح من نتائج الدراسة الميدانية الدور المهم للمتغير المستقل ممارسات إدارة الاحتواء العالي في الحد أو السيطرة على المتغير التابع وهو التنمر في مكان العمل.
أهم المقترحات: أهمية استقطاب العاملين الذين يمتلكون مقومات وخصائص ممارسات إدارة الاحتواء العالي للحد من الظواهر السلبية التي تعمل على تحطيم المنظمة ومن هذه السلوكيات التنمر في مكان العمل.
أثر بعض المتغيرات الاقتصادية الزراعية على قيمة الإنتاج الحيواني في العراق دراسة قياسية باستخدام نموذج الانحدار الذاتي الموزع للإبطاء الزمني (ADRL) للمدة (1990-2021)
Authors: عيدان الجرجري طه محمد , لطيف الدوري باسم فاضل
Published: January 2024

يهدف البحث إلى التعرف على أهم المتغيرات الاقتصادية الزراعية التي لها تأثير على اتجاهات قيمة الإنتاج الحيواني في العراق، وتكمن أهمية البحث من خلال توضيح علاقة وقدرة المتغيرات الاقتصادية الزراعية على دعم وتصحيح الاختلالات والتشوهات التي تصيب قيمة الإنتاج الحيواني في العراق للمدة (1990-2021)، باستخدام نموذج الانحدار الذاتي ذي الابطاء الموزع، واستخلصت البحث مجموعة من النتائج لعل أهمها: وجود علاقة تكامل مشترك بين متغيرات البحث في المدى الطويل، وارتباط المتغيرات (اعداد الحيوانات الحية، كمية الحيوانات المذبوحة وكمية الاعلاف) بعلاقة ايجابية وذات معنوية إحصائية مع قيمة الانتاج الحيواني في العراق في الاجل الطويل، اما كمية اللقاحات فكانت لها تأثير معنوي سالب على قيمة الانتاج الحيواني في العراق. وخرج البحث بجملة من المقترحات ومن أهمها: ضرورة العمل على تنمية الثروة الحيوانية عن طريق الاسراع بتأهيل القطاع الخاص والمؤسسات الكبيرة التي تعمل في مجالات الانتاج الحيواني "حقول الدواجن، محطات تربية الابقار" ودعم الطب البيطري من خلال توفير المختبرات المتطورة واللقاحات لمواجهة الامراض التي تصيب الحيوانات وتزيد من انتاجيتها.
نموذج برنامج تدقيق لتدقيق معاملات العملات المشفرة
Authors: حسين علي آية طه , محمد جميل سنان زهير
Published: January 2024

تُعدّ العملات المشفرة من التطورات الحالية والمستقبلية المهمة إذ إن هذه الأهمية أدت إلى قيام دراسات عدة لها ولكن لم تكن هنالك دراسة صريحة لبيان إجراءات التدقيق بوصفه موضوع معاصر ومستقبلي، ومن هنا جاءت هذه الدراسة للبحث في وضع إجراءات برنامج التدقيق الخاصة في تدقيق معاملات العملات المشفرة.
          يهدف البحث إلى بيان أهمية وضع إجراءات خاصة لتدقيق عمليات المحاسبة عن العملات المشفرة في ظل معايير التدقيق الدولية، وتقديم برنامج تدقيق للعملات المشفرة، وهو ما يُعدّ الهدف الرئيسي للبحث.
          ولتحقيق أهداف البحث والإجابة عن أسئلته، قام الباحثان بإتباع المنهج الاستنباطي التحليلي في الجانب النظري، وتم إعداد الجانب العملي (نموذج برنامج تدقيق) بالاعتماد على ما هو مطلوب من قبل المنظمات المهنية وما توصلت له الأبحاث الأخيرة في هذا المجال. وقد توصل البحث إلى العديد من الاستنتاجات، كان أهمها أن هناك إجراءات معينة لتدقيق معاملات العملات المشفرة وعلى مراقب الحسابات إتباعها لتقديم معلومات مفيدة لأصحاب المصالح للمساعدة في التنبؤ وتقييم كفاءة وفاعلية الإدارة، وكذلك الهدف الأبرز وهو المساعدة في عرض القوائم المالية بصورة عادلة لاتخاذ القرارات الملائمة. وأوصى الباحثان بضرورة قيام المنظمات المهنية بإصدار معيار أو تفسيرات تختص بمعالجة مشكلات التدقيق عن العملات المشفرة، وأوصى كذلك بتعزيز الجوانب المعرفية للأكاديميين والمهنيين فيما يتعلق بموضوعات العملات المشفرة.
Cloud service for differential diagnosis and personalized treatment of inflammatory heart diseases
Authors: Shalfeeva Elena Arefyevna , Petryaeva Margarita Vyacheslavovna , Okun Dmitry Borisovich , Fedorishchev Leonid Aleksandrovich , Kovalev Roman Igorevich , Gribova Valeria Viktorovna
Published: January 2024

Исследуется автоматизация проведения полного цикла диагностики и
дифференциальной диагностики воспалительных заболеваний сердца и
назначения персонифицированного лечения. Методом исследования является
формирование декларативных баз знаний и объясняющего свои результаты
решателя по единой онтологии. Онтологический решатель интерпретирует
формализованные знания при получении сведений о новом медицинском случае
(пациенте).

Описаны общие принципы разработки и концептуальная архитектура
интеллектуального сервиса с декларативными знаниями. Сформированы
информационные компоненты для воспалительных заболеваний сердца и
программные компоненты для полного цикла диагностики и дифференциальной
диагностики, персонифицированного лечения. Указаны источники знаний и
проведено тестирование на случаях из практики, описанных в литературе.
Приведено обоснование выбора технологий и алгоритмов, выявлены и
сформулированы требования к программному комплексному сервису, шаги
по разработке всех компонентов.

Сервис поддержки принятия диагностических решений со свойствами
объяснимого искусственного интеллекта в кардиологии реализован на
медицинском портале облачной платформы IACPaaS. Платформа позволяет
масштабировать предложенное решение и обеспечивает доступ практикующих
врачей со свободной регистрацией для экспериментов в реальных
ситуациях.
The impact of the industrial special economic zone “Lipetsk” on socio-economic processes of the region
Authors: Nadtochiy Yu. B. , Zhukovskii A. D.
Published: January 2024

The processes of economic development of the Russian regions nowadays represent a deep practical interest in the professional community, which requires further study and observation in dynamics. Due to natural and artificial circumstances and reasons, the regions of the country are developed extremely unevenly. There are no actual systematisation of the economic development of the federal subjects management and territorial clusterisation according to their development indicators. The Lipetsk region historically and today is also no exception. The region is part of the Central Federal District and a significant industrial centre here. More than 18 years ago the industrial special economic zone (hereinafter referred to as ISEZ) “Lipetsk” was created. The Lipetsk region is one of the first regions among various investment ratings in terms of quality and volume of investments, as well as among implemented investment projects, involving domestic and foreign capital. The purpose of this study is to determine the impact of the activities of the ISEZ “Lipetsk” on the socio-economic processes of the region and to study the possibilities of assessing such an impact.
Development of the industrial sector in the Russian regions − cluster analysis
Authors: Nikolaev A. A.
Published: January 2024

In the course of the study, a cluster analysis of Russian regions was performed based on characteristics associated with industrial and economic development. As a result, it was established that there is a direct correlation between the level of industrial production and general indicators of economic well-being of the regions such as gross regional product (hereinafter referred to as GRP) and GRP per capita. Within the framework of the cluster analysis, on the basis of above mentioned characteristics, the regions were divided into three groups. The most numerous of them is the group of regions with the lowest level of development. This is primarily due to the uneven distribution of natural resources throughout the country, when a small number of regions have faster development of the mining sector compared to others. Although it is worth noting that the development of the manufacturing industry also has a significant impact on economic well-being. Therefore, the first group, consisting of the most successful regions in terms of economic and industrial indicators, included not only oil-producing and capital regions, but also large industrial centres such as Tatarstan, Sverdlovsk and Chelyabinsk regions. A qualitative analysis of the results showed the success of the current cluster analysis of Russian regions. Only a few uncharacteristic values of indicators were noted which have significant differences for their cluster groups. This mainly applies to oil-producing regions where the level of the extractive sector development is too high compared to the rest of the regions of its group. Although, in general, regarding the sum of indicators, these regions were classified into a specific cluster.
Monitoring of national projects in Russia and risks associated with their implementation
Authors: Stroev V. V. , Kuznetsov N. V.
Published: January 2024

National projects developed in accordance with the national development goals of Russia allow us to implement key tasks for socio-economic development of the country, as well as welfare of its population. Evaluation of performance indicators and control points at all stages of national projects functioning allows to determine the need for operational management decisions at local, regional, and federal levels. In the conducted research, the monitoring implementation of national projects in Russian system has been considered. The assessment of key risks and possible threats to national projects implementation has been performed out, as well as possible ways to solve problems proposed. The main documents that regulate national projects execution, the mechanism and structure of national projects monitoring have also been studied. Traditional theoretical research methods were used in the article, including system analysis and synthesis, as well as inductive and deductive approaches that made it possible to evaluate the “Electronic Budget” – a unified state integrated information system for public finance management of Russia, as well as a separately functioning system based on the “Center for Information Technology and Systems of Executive Authorities named after A.V. Starovoitov” called “Information system for monitoring national projects and programmes in the social sphere”. The analysis results obtained allowed us to conclude the key problems and errors in the process of monitoring national projects implementation in Russia and to make suggestions for their elimination.
Gravitational model: analysis of mutual trade of the Eurasian Economic Union countries
Authors: Zhilkin O. N. , Balashova S. A. , Abramova A. A.
Published: January 2024

This study presents the aggregative data analysis concerning foreign trade of the Eurasian Economic Union (hereinafter referred to as EAEU) countries. A gravity model of the foreign trade in several modifications between 2011 and 2019 (the period before the COVID-19 pandemic) was applied. On the basis of the conducted research it was discovered how fast the impact of the distance factor between foreign economic partners decreases with consideration to the time factor. Also those industries and spheres of activity were identified where the factor may be the least important or where the model is not applicable at all. Besides, the authors gave recommendations to include additional factors in the gravitational model if it is applied for analysis and forecasting of foreign trade with border states or states that are not part of the EAEU.
Development of methodology for assessing the effectiveness of tax control types
Authors: Kolesnikova E. N.
Published: January 2024

There are two purposes of the study, the results of which are summarised in this article: to systematise modern approaches of assessing the effectiveness of certain tax control forms and to develop proposals for optimising ways to identify the most effective of them. The conclusions made in the article about the change in the determinants that condition the effectiveness of tax control allowed us to justify the need for transformation of approaches to its assessment. The risk-oriented approach proposed by the author to assess the effectiveness of certain tax control types differs from existing views and has not been proposed or considered in the scientific literature before. It focuses on a comparative assessment of the rate of change in the number of taken measures and the results of tax control. Conclusions made on the basis of the implementation of the risk-based approach to assess effectiveness of various tax control forms confirm the conclusions made during the application of quantitative and coefficient methods. However, they are less laborious to obtain results and more visual.
The system of investment and construction project management as a component of the company’s sustainable development
Authors: Astafyeva O. E. , Sianin S. V.
Published: January 2024

Investment and construction companies that have adopted the principles of sustainable development need to transform the project management system accordingly. The article discusses the integration of sustainable development in the management system of investment and construction projects. For this purpose, an analysis of scientific works in this area was conducted. During the study, the correspondence of adaptive management to the concept of sustainable development was revealed. As a result, the certain project management tools (Impact Map, management tasks assignment matrix / RACI (responsible, accountable, consult, inform), kanban board, DMAIC concept (define, measure, analyse, improve, control), Lean Six Sigma, business model canvas for sustainability) were compared with the mechanisms for integration of sustainable development (the definition of sustainable development activities, commitment action log, acceptance (consideration) of complaints, the improvement of sustainable development implementation in investment and construction projects and determination of sustainable development results in reporting). As a result, the problems of accounting and tracing at all stages of sustainable development requirements, as well as the problems of formation of correspondence reporting, were solved.
Credit factor of investment development of the Russian economy under sanctions
Authors: Loginov B. B.
Published: January 2024

We need to prevent a “drawdown” of the Russian economic growth as a result of a large-scale outflow of foreign and domestic capital from the Russian economy under the influence of a repeated increase in sanctions pressure of the West since the beginning of the special military operation of the Russian Federation in Ukraine in 2022. Thus the regulatory authorities, responsible for credit and investment policy, should pay primary attention to measures that support bank lending for the purpose of investment development. It is the source of investment financing in our country that is key for the corporate sector which is not organisationally connected with the state. It is the source that is today’s subject to the greatest destabilising influence of external and internal factors. Firstly, foreign bank loans which were previously five times greater than other forms of foreign capital in replenishing fixed assets, have decreased significantly. Secondly, lenders from the East were unable to replace the “lost” volumes of Western loans and creditors, among which the American ones even rose from the 4th to the 2nd place by March 2023 due to reduced total volumes. Thirdly, in the list of Western sectoral sanctions, measures to break credit connections were the very first and still remain the most painful for the Russian business. Finally, the excessively high interest rate used by the Central Bank to cool currency profiteers and accelerated inflation even aggravates the problem of a compressed credit base for investment in capital stock.
Components of the quality of education differentiation: new reality of human capital formation
Authors: Ivanov S. Yu. , Ivanova D. V. , Tazov P. Yu.
Published: January 2024

The article discusses the key areas that determine the social differentiation caused by the discrepancy between the educational services market and the labour market. Based on the social statistics data and the results of sociological research the reasons influencing the formation of professional trajectories of young people are investigated and the content of human capital within the framework of the institute of education is analysed. The authors paid special attention to the analysis of the institute which in modern society reproduces the needs of the economic system and strengthens social differentiation, allows an individual to make a holistic choice on the basis of the available educational potential. At the same time, the market of educational services is considered in conditions when supply and demand are separated in time. The search for balance in this market is the result of cooperation between social partners and the efforts of the state.
Assessment of the innovation activity of the industry by the manufacturability level
Authors: Kudryavtseva S. S. , Shinkevich M. V. , Kharitonov D. V.
Published: January 2024

The relevance of the study is related to the need to activate innovation in the context of socio-economic and geopolitical challenges that the Russian economy faces. In the innovative economy, the labour costs and physical capital are reduced, and the share of intellectual capital in the first-cost of created products increases. There is a rapid growth in the productivity of production factors while their first-cost decreases. All this suggests that we need to study innovation processes in relation to the manufacturability level of production as a system characteristic that describes the type of a particular production. The authors present the structure of production types by the level of manufacturability and types of economic activity that form them. The specificity of the innovation activity of the industry is indicated according to the level of production manufacturability. The comparative characteristic of innovation activity of this phenomenon on various levels is also given.
The digital maturity of the Russian metallurgical industry: drivers and growth challenges in the new geopolitical environment. Part I. Assessment of the innovation potential of digital transformation
Authors: Prokhorova I. S. , Ustinov V. S. , Elkhova A. V.
Published: January 2024

The article examines the problems on implementing the strategy of digital transformation of industries in the Russian economy based on the metallurgical industry that determines the economic growth opportunities of the three industrial sectors which form the largest part of gross domestic income. The subject of the study is the level of digital maturity of metallurgical companies under economic sanctions. The purpose of the study is to determine the current level of digitalisation of metallurgical companies and to form the directions for possible development of digital technologies in the context of anti-Russian sanctions. The methodology of the study is based on system, indicative, comparative and statistical methods of analysis. The first part of the study is devoted to a comprehensive assessment of the industry’s digital maturity and identification of key trends in business digitalisation to characterise its innovation potential as a major resource provider in the Russian industry. A system of indicators for assessing digital maturity based on variable methodologies is considered a criterion for assessing innovation potential of digital business transformation. The results of the analysis show that the metallurgy complex has sufficient growth potential for business digital maturity and refers to the drivers of digitalisation.
Features of implementation of catering enterprises strategies in modern conditions (on the example of Russian largest cities)
Authors: Sedelnikov V. M.
Published: January 2024

The article is devoted to the study of catering enterprises strategy implementation in the conditions of economic crisis situations of 2020–2022. In particular, the article highlights the foreign scientists’ points of view regarding the definition of the “strategy implementation” concept, and the process approach to the definition is provided as a fundamental one. The scientific novelty lies in the fact that on the basis of the study key catering market trends for the period 2020–2022 were identified. The following main statistical indicators were used: the turnover of catering in the Russian entities and per capita, the number of places in catering enterprises and the availability of catering enterprises per 1,000 population. It was concluded that apart from the ongoing post-coronavirus trends, such as ensuring a high level of quality and safety of manufactured products, changing the supply chains, delivery of finished goods and takeaway format, in modern conditions, consumers are becoming more economical and rational in their expenses and are trying to optimise their budget. In 2022 and 2023, the following trends remain: establishment of  interaction between catering enterprises and consumers, personalisation of clients, support of positive “word of mouth” and establishment of partnerships with local suppliers of  products and ingredients to ensure supply stability. An assessment of catering enterprises strategy implementation with consideration to the influence of the identified trends is emphasised as a direction for further research.
Preparation and characterization of transferable encapsulated dye-sensitized solar cells
Authors: Hartwich Patrick , Raghu Swathi Naidu Vakamulla , Müller Maurice , Pritzel Christian , Haring Bolívar Peter , Killian Manuela S.
Published: January 2024

The increasing demand for sustainable energy as a means to combat the impact of climate change is addressed via a novel concept in the present work. Herein, the development of encapsulated dye-sensitized solar cells, canonically “solar capsules”, for photovoltaic applications on alternative surfaces, such as facades, is presented. The solar capsule assembly houses all components necessary for photovoltaic energy conversion, enclosed within a semiconductor nanotubular array, making them truly unique in their construction. This capsule-style unit enables an easy transfer and draft onto a wide range of materials and surfaces for photovoltaic functionalization and applications. This type of dye-sensitized solar cell typically consists of transferred solar capsules and two additional electrodes. The design and construction of solar capsules have high economic viability as they can seamlessly be up-scaled using commercially established techniques such as anodization and subsequent functionalization. This work demonstrates a working model of such a capsule by fabricating TiO2 nanotubes that are functionalized via facile dip- and spin-coating techniques in a wet lab at ambient conditions. These prototype solar capsules are characterized in bulk and are thoroughly investigated at the nanoscale for information on the chemical distribution of the constituents, as they may be influenced during the manufacturing process.
Giant Band Degeneracy via Orbital Engineering Enhances Thermoelectric Performance from Sb2Si2Te6 to Sc2Si2Te6
Authors: Dou Wenzhen , Spooner Kieran , Kavanagh Seán , Zhou Miao , Scanlon David O.
Published: January 2024

The complex interrelationships among thermoelectric parameters mean that a priori design of high-performing materials is difficult. However, band engineering can allow the power factor to be optimized through enhancement of the Seebeck coefficient. Herein, using layered Sb2Si2Te6 and Sc2Si2Te6 as model systems, we comprehensively investigate and compare their thermoelectric properties by employing density functional theory combined with semiclassical Boltzmann transport theory. Our simulations reveal that Sb2Si2Te6 exhibits superior electrical conductivity compared to Sc2Si2Te6 due to lower scattering rates and more pronounced band dispersion. Remarkably, despite Sb2Si2Te6 exhibiting a lower lattice thermal conductivity, the introduction of Sc-d orbitals dramatically increases conduction band degeneracy in Sc2Si2Te6, yielding a significantly improved Seebeck coefficient relative to Sb2Si2Te6. As a result, Sc2Si2Te6 is predicted to achieve an extraordinary dimensionless figure of merit (ZT) of 3.51 at 1000 K, which significantly surpasses the predicted maximum ZT of 2.76 for Sb2Si2Te6 at 900 K. This work suggests that engineering band degeneracy through compositional variation is an effective strategy for improving the thermoelectric performance of layered materials.
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation
Authors: Haas Brittany , Lim Ngiap-Kie , Jermaks Janis , Gaster Eden , Guo Melody , Malig Thomas , Werth Jacob , Zhang Haiming , Toste F. Dean , Gosselin Francis , Miller Scott , Sigman Matthew
Published: January 2024

Methods to access chiral sulfur (VI) pharmacophores are of interest in medicinal and synthetic chemistry. We report the desymmetrization of unprotected sulfonimidamides via asymmetric acylation with a cinchona-phosphinate catalyst. The desired products are formed in excellent yield and enantioselectivity with no observed bis-acylation. A data science-driven approach to substrate scope evaluation was coupled to high throughput experimentation (HTE) to facilitate statistical modeling in order to inform mechanistic studies. Reaction kinetics, catalyst structural studies, and density functional theory (DFT) transition state analysis elucidated the turnover-limiting step to be the collapse of the tetrahedral intermediate and provided key insights into the catalyst-substrate structure-activity relationships responsible for the origin of enantioselectivity. This study offers a reliable method for accessing enantioenriched sulfonimidamides to propel their application as pharmacophores and serves as an example of the mechanistic insight that can be gleaned from integrating data science and traditional physical organic techniques.
Theoretical Photoelectron Spectroscopy of Metal-Metal Quintuple Bonds: Relativity-Driven Reordering of Frontier Orbitals
Authors: Ghosh Abhik , Conradie Jeanet
Published: January 2024

A recent reinvestigation of the gas-phase photoelectron spectra of Group 6 metal-metal quadruple-bonded complexes with scalar-relativistic DFT calculations showed that common exchange-correlation functionals reproduce the lowest ionization potentials in a semiquantitative manner. The finding encouraged us to undertake a DFT study of metal-metal quintuple bonds in a set of bisamidinato complexes with the formula MI2[HC(NR)2]2 (M = Cr, Mo, W; R = H, Ph, 2,6-iPr2C6H3) and idealized D2h symmetry. Scalar-relativistic OLYP/STO-TZ2P calculations indicated significant shifts in valence orbital energies among the three metals, which translate to lower first ionization potentials, higher electron affinities, and lower HOMO-LUMO gaps for the W complexes, relative to their Cr and Mo counterparts. These differences are largely attributable to substantially larger relativistic effects in the case of tungsten relative to its lighter congeners.
A frontier-orbital view of the initial steps of lytic polysaccharide monooxygenase reactions
Authors: Wieduwilt Erna Katharina , Lo Leggio Leila , Donovan Hedegård Erik
Published: January 2024

Lytic polysaccharide monooxygenases (LPMOs) are copper enzymes that oxidatively cleave the strong C-H bonds in recalcitrant polysaccharides, thereby playing a crucial role in biomass degradation. Recently, LPMOs have also been shown to be important for several pathogens. It is well established that the Cu(II) resting state of LPMOs is inactive, and the electronic structure of the active site needs to be altered to transform the enzyme into an active form. Whether this transformation occurs due to substrate binding or due to a unique priming reduction has remained speculative. Starting from four different crystal structures of the LPMO LsAA9 with well-defined oxidation states, we use a frontier molecular orbital approach to elucidate the initial steps of the LPMO reaction. We give an explanation for the requirement of the unique priming reduction and analyse electronic structure changes upon substrate binding. We further investigate how the presence of the substrate could facilitate an electron transfer from the copper active site to an H2O2 co-substrate. Our findings could help to control experimental LPMO reactions.
Innovative Virtual Screening of PD-L1 Inhibitors: The Synergy of Molecular Similarity, Neural Networks, and GNINA Docking
Authors: To Van-Thinh , Phan Tieu-Long , Doan Bao-Vy Ngoc , Nguyen Phuoc-Chung Van , Nguyen Dong-Nghi Hoang , Le Quang-Huy Nguyen , Nguyen Hoang-Huy , Trinh The-Chuong , Truong Tuyen Ngoc
Published: January 2024

Immune checkpoint inhibitors have garnered significant attention in oncological research over recent years. A plethora of studies have elucidated that inhibitors targeting the Programmed Death-Ligand 1 (PD-L1) play a pivotal role in circumventing the evasion mechanisms of cancer cells against the immune system. This study aimed to develop an integrated screening model combining an Artificial Neural Network (ANN), Molecular Similarity (MS) assessments, and GNINA 1.0 molecular docking, targeting PD-L1 inhibitors. A database of 2044 substances with known PD-L1 inhibitory activity was compiled from Google Patents and used to enhance molecular similarity evaluations and train the machine learning model. For retrospective validation of the docking procedure, the human PD-L1 protein, with the Protein Data Bank (PDB) ID: 5N2F, was employed as a control. In this phase of the study, 15,235 compounds from the DrugBank database were subjected to a series of screening processes: initially through medicinal chemistry filters, followed by MS assessments, the ANN model, and culminating with molecular docking using GNINA 1.0. The decoy generation yielded promising outcomes, evidenced by an AUC-ROC 1NN value of 0.52 and Doppelganger scores with a mean of 0.24 and a maximum of 0.346, indicating a high resemblance of the decoys to the active set. For MS, the AVALON emerged as the most effective fingerprint for similarity searching, demonstrating an Enrichment Factor (EF) of 1% at 10.96%, an AUC-ROC of 0.963, and an optimal similarity threshold of 0.32. The ANN model demonstrated superior performance in cross-validation, achieving an average precision of 0.863±0.032 and an F1 score of 0.745±0.039, outperforming both the Support Vector Classifier (SVC) and Random Forest (RF) models, albeit not significantly. In external validation, the ANN model maintained its superiority with an average precision of 0.851 and an F1 score of 0.790. GNINA 1.0, employed for molecular docking, was validated through redocking and retrospective control, achieving an AUC of 0.975, with a critical cnn_pose_score threshold of 0.73. From the initial 15,235 compounds, 128 were shortlisted using the MS and ANN models. Further screening through GNINA 1.0 identified 22 potential candidates, among which (3S)-1-(4-acetylphenyl)-5-oxopyrrolidine-3-carboxylic acid emerged as the most promising, with a cnn_pose_score of 0.79, a PD-L1 inhibitory probability of 70.5%, and a Tanimoto coefficient of 0.35.