bluuebunny/crossref_metadata_2025 huggingface dataset:
Seeding the Self-Assembly of DNA Origamis at Surfaces
Authors: Cao Huan , Abel Gary R. , Gu Qufei , Gueorguieva Gloria-Alexandra V. , Zhang Yehan , Nanney Warren A. , Provencio Eric , Ye Tao
Published: December 2019

Unlike supramolecular self-assembly methods that can organize many unique components into designer shapes in a homogeneous solution (e.g., DNA origami), only relatively simple, symmetric structures consisting of a few unique components have been self-assembled at solid surfaces. As the self-assembly process is confined to the surface/interface by mostly nonspecific attractive interactions, an open question is how these interfacial interactions affect multicomponent self-assembly. To gain a mechanistic understanding of the roles of surface environment in DNA origami self-assembly, here we studied the oligonucleotide-assisted folding of a long single-stranded DNA (ssDNA scaffold) that was end-tethered to a dynamic surface, which could actively regulate the DNA-surface interactions. The results showed that even weak surface attractions can lead to defective structures by inhibiting the merging of multiple domains into complete structures. A combination of surface anchoring and deliberate regulation of DNA-surface interactions allowed us to depart from the existing paradigm of surface confinement via nonspecific interactions and enabled DNA origami folding to proceed in a solution-like environment. Importantly, our new strategy retains the key advantages of surface-mediated self-assembly. Moreover, surface-anchored oligonucleotides could sequence-specifically initiate the growth of DNA origamis of specific sizes and shapes. Our work opens up new opportunities for encoding information into a surface and expressing the information into complex DNA surface architectures for potential nanoelectronics and nanophotonics applications. In addition, our new approach to surface confinement may facilitate the 2D self-assembly of other molecular components, such as proteins, as maintaining conformational freedom may be a general challenge in the self-assembly of complex structures at surfaces.
Metabolomics Analysis Reveals Both Plant Variety and Choice of Hormone Treatment Modulate Vinca Alkaloid Production in Catharanthus Roseus.
Authors: Fraser Valerie , Philmus Benjamin , Megraw Molly
Published: December 2019

The medicinal plant Catharanthus roseusproduces numerous secondary metabolites of interest for the treatment of many diseases—most notably for the terpene indole alkaloid (TIA) vinblastine, which is used in the treatment of leukemia and Hodgkin’s lymphoma. Historically, methyl jasmonate (MeJA) has been used to induce TIA production, but in the past, this has only been investigated in either whole seedlings, cell culture, or hairy root culture. In this work, we investigate the induction capabilities of MeJA and ethylene, a different phytohormone, in both the shoots and roots of two varieties of C. roseus. Using LCMS and RT-qPCR, we demonstrate the importance of variety selection, as we observe markedly different induction patterns of important TIA precursor compounds. Additionally, both phytohormone choice and concentration have significant effects on TIA biosynthesis. Finally, our study suggests that several early-induction pathway steps as well as pathway-specific genes are likely to be transcriptionally regulated. Our findings highlight the need for a complete set of ’omics resources in commonly used C. roseus varieties.
Aza-BODIPY Platform: Towards an Efficient Water-Soluble Bimodal Imaging Probe for MRI and Near-Infrared Fluorescence
Authors: Flores Oceane , Pliquett Jacques , Abad Galan Laura , Lescure Robin , Denat Franck , Maury Olivier , Pallier Agnès , Bellaye Pierre-Simon , Collin Bertrand , Même Sandra , Bonnet Celia S. , Bodio Ewen , Goze Christine
Published: December 2019

In this study, an original aza-BODIPY system comprising two Gd3+ complexes has been designed and synthesized for magnetic resonance imaging/optical imaging application, by functionalization of the boron center. This strategy enabled to obtain a positively-charged bimodal probe, which displays an increased water-solubility, optimized photophysical properties in the near-infrared region, and very promising relaxometric properties. The absorption and emission wavelengths are 705 and 741 nm respectively, with a quantum yield of around 10 % in aqueous media. Moreover, the system does not produce singlet oxygen upon excitation, which would be toxic for tissues. The relaxivity obtained is high at intermediate fields (16.1 mM-1.s-1 at 20 MHz and 310 K) and competes with that of bigger or more rigid systems. A full relaxometric and 17O NMR study and fitting of the data using the Lipari-Szabo approach showed that this high relaxivity can be explained by the size of the system and the presence of some small aggregates. These optimized photophysical and relaxometric properties highlight the potential use of such systems for future bimodal imaging studies.
Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds
Authors: Grill Matthias , Patt Melanie , Odermatt Alex
Published: December 2019

Anabolic androgenic steroids (AAS) are frequently used either clinically, by athletes, or for body shaping due to their muscle building and performance enhancing properties. AAS misuse is associated with cardiovascular diseases, mood changes and endocrine issues. Despite the recognition of the severe adverse effects of AAS misuse, the underlying molecular mechanisms are insufficiently understood. Selective androgen receptor modulators (SARMs) are supposed to diminish the adverse androgenic AAS effects while maximizing anabolic effects. In order to obtain androgen receptor modulating compounds of high purity for mechanistic in vitro investigations, this study summarizes protocols of optimized chemical synthesis for five AAS and two SARMs.
Investigation of Au SAMs Photoclick Derivatization by PM-IRRAS
Authors: Workentin Mark , Lagugné-Labarthet François , Legge Sidney
Published: December 2019

In this work we present a clean one-step process for modifying headgroups of self-assembled monolayers (SAMs) on gold using photo-enabled click chemistry. A thiolated, cyclopropenone-caged strained alkyne precursor was first functionalized onto a flat gold substrate through self-assembly. Exposure of the cyclopropenone SAM to UV-A light initiated the efficient photochemical decarbonylation of the cyclopropenone moiety, revealing the strained alkyne capable of undergoing the interfacial strain-promoted alkyne-azide cycloaddition (SPAAC). Irradiated SAMs were derivatized with a series of model azides with varied hydrophobicity to demonstrate the generality of this chemical system for the modification and fine-tuning of the surface chemistry on gold substrates. SAMs were characterized at each step with polarization-modulation infrared reflection-absorption spectroscopy (PM-IRRAS) to confirm successful functionalization and reactivity. Furthermore, to showcase the compatibility of this approach with biochemical applications, cyclopropenone SAMs were irradiated and modified with azide-bearing cell adhesion peptides to promote human fibroblast cell adhesion, then imaged by live cell fluorescence microscopy. Thus, the “photoclick” methodology reported here represents an improved, versatile, catalyst-free protocol that allows for a high degree of control over the modification of material surfaces, with applicability in materials science as well as biochemistry.
D3R Grand Challenge 4: Blind Prediction of Protein-Ligand Poses, Affinity Rankings, and Relative Binding Free Energies
Authors: parks conor , Gaieb Zied , Chiu Michael , Yang Huanwang , Shao Chenghua , Walters W. Patrick , Jansen Johanna M. , McGaughey Georgia , Lewis Richard A. , Bembenek Scott D. , Ameriks Michael K. , Mirzadegan Tara , Burley Stephen K. , Amaro Rommie , Gilson Michael
Published: December 2019

The Drug Design Data Resource (D3R) aims to identify best practice methods for computer aided drug design through blinded ligand pose prediction and affinity challenges. Herein, we report on the results of Grand Challenge 4 (GC4). GC4 focused on proteins beta secretase 1 and Cathepsin S, and was run in an analogous manner to prior challenges. In Stage 1, participant ability to predict the pose and affinity of BACE1 ligands were assessed. Following the completion of Stage 1, all BACE1 co-crystal structures were released, and Stage 2 tested affinity rankings with co-crystal structures. We provide an analysis of the results and discuss insights into determined best practice methods.
Non-Covalent Interactions Atlas Benchmark Data Sets: Hydrogen Bonding
Authors: Řezáč Jan
Published: December 2019

The Non-Covalent Interactions Atlas project (www.nciatlas.org) aims to cover a wide range of non-covalent interactions with a new generation of benchmark data sets. This paper presents the first two data sets focused on hydrogen bonding: HB375, featuring neutral systems, and IHB100 for ionic H-bonds. Both data sets are complemented by ten-point dissociation curves (HB375x10, IHB100x10). The interaction energies are extrapolated to the CCSD(T)/CBS limit from calculations in large basis sets. The paper also summarizes the design principles that will be used to construct the subsequent data sets in the series. The testing of DFT-D methods on the HB375 set has revealed interesting, previously unnoticed issues. The application of the new data to the testing and parameterization of semiempirical QM methods is also discussed.
Building Attention and Edge Convolution Neural Networks for Bioactivity and Physical-Chemical Property Prediction
Authors: Withnall Michael , Lindelöf Edvard , Engkvist Ola , Chen Hongming
Published: December 2019

We introduce Attention and Edge Memory schemes to the existing Message Passing Neural Network framework for graph convolution, and benchmark our approaches against eight different physical-chemical and bioactivity datasets from the literature. We remove the need to introduce a priori knowledge of the task and chemical descriptor calculation by using only fundamental graph-derived properties. Our results consistently perform on-par with other state-of-the-art machine learning approaches, and set a new standard on sparse multi-task virtual screening targets. We also investigate model performance as a function of dataset preprocessing, and make some suggestions regarding hyperparameter selection.
Political Ideology and Organisational Espousal: A Political-Historical Analysis of Dr. John Garang De Mabior’s “New Sudan Vision”
Authors: Garang Kuir ë
Published: December 2019

The Sudan People’s Liberation Movement and Army (SPLM/A) has for decades presented a “New Sudan” as its “vision.” But SPLM/A’s official ideology was socialism and its vision a united secular and socialist Sudan. With time, this vision became “New Sudan” and its presumptive guiding ideology became “The New Sudan Vision” (NSV) without any official institutionalisation of this NSV. In fact, “NSV” does not appear in the Movement’s founding manifesto until the revision of the manifesto in 2008 when NSV was incoherently included. I argue, therefore, that the New Sudan Vision was not really an SPLM/A political ideology but John Garang’s ideology. Besides, its immediate disappearance in South Sudan after the death of John Garang and the overwhelming vote for independence was an unequivocal rejection of NSV by the South Sudanese.
Evolution and changes of tourism in Macedonia in the post-socialist period (1991–2018)
Authors: Iliev Dejan
Published: December 2019

The study provides a historical and contextual analysis of the evolution of tourism in Macedonia. The time scope is defined as the period between 1991 and in 2018. The study investigates the tourism development in Macedonia in the post-socialist period of the country, using the Butler (1980) Tourist Area Life Cycle (TALC) model as an analytical tool. The model provides a framework to explain the complex processes of the development and changes in tourism in the country over the years. For this purpose, an analysis of secondary data sources is implemented to find the changes in the evolutionary stages of tourism development. The findings show that tourism in Macedonia is in a stage of development, and that it has not yet reached the consolidation stage. Lastly, the study offers a better understanding of how tourism in Macedonia is changing in the complex post-socialist period.
Mapeando os Estudos de Novas Mídias no Brasil
Authors: Simões Paula Guimarães , França Vera Regina Veiga , Oliveira Ana Karina , Lima Laura Antônio , Sepulveda Lucas Afonso , Barroso Lívia , Afonso Maria Lúcia , Lopes Suzana , Lobato Maíra , Basílio Paulo , Bontempo Clara , Pereira Samuel
Published: December 2019

A proposta do artigo é identificar autoras/es e teorias utilizadas/os como referência por pesquisadoras/es da área de Novas Mídias no Brasil. O corpus selecionado inclui 100 artigos da Compós durante o período de 2006 a 2015. Essa apresentação específica faz parte de uma pesquisa mais ampla que almeja apreender as teorias contemporâneas que alicerçam o campo da Comunicação no país. A análise destaca a ênfase das pesquisas na questão da técnica, associada ao poder, buscando compreender o papel das novas tecnologias na configuração da sociedade, da subjetividade dos indivíduos, de seus processos cognitivos.Palavras-chave: Teorias da Comunicação, Epistemologia da Comunicação, Novas Mídias.
Beco das Artes: Festas, imaginários e ambiências subversivas na cidade do Rio de Janeiro.
Authors: Fernandes Cíntia Sanmartin , La Rocca Fabio , Barroso Flávia Magalhães
Published: December 2019

A partir das considerações de que a festa: a) é historicamente uma paisagem urbana; b) imputa à rua novos comportamentos e usos sociais; c) apresenta a transição de uma paisagem cotidiana para uma festiva, propondo certa ruptura; d) carrega em si um possível caráter transgressor mediado pela ambiência noturna, o presente artigo tem como objetivo analisar as experiências festivas noturnas de rua a partir de práticas subversivas que se intensificaram nos últimos 5 anos na cidade do Rio de Janeiro, especificamente no Beco das Artes. Para tanto, nos alicerçamos nas teorias e metodologias da percepção, dos sentidos e do imaginário social.
Rock no Rio Vermelho Afetos e territorialidades em Salvador
Authors: Farias Daniel , Filho Jorge Cardoso
Published: December 2019

Este artigo apresenta e interpreta práticas de rock desenvolvidas em Salvador, no bairro do Rio Vermelho, a partir de uma chave de leitura que articula engajamentos afetivos aos territórios ocupados e apropriados por integrantes da cultura rock. O estudo é focalizado em três práticas específicas: o Rock no Vacachorro, evento que ocorreu no Largo de Santana, mais conhecido como Largo da Dinha; o Bate Papo Saco de Vacilo, na casa de show Bardos e Bardos, e o Faça Você Mesma, no Mercadão C.C. São apresentados os afetos que se expressam nessas práticas, as formas de engajamento dos integrantes e construções de territorialidades diversas no bairro do Rio Vermelho
Una propuesta incluyente, hacia la comprensión oral de estudiantes ciegos y videntes
Authors: Calderón Peña Ludivia , Linares Cortés Leydy Yicela , Garcí­a Orjuela Erly Mercedes
Published: December 2019

Frente a la educación inclusiva, el presente artí­culo propone determinar el efecto que tiene una propuesta pedagógica y didáctica mediada por los principios y pautas del Diseño Universal para el Aprendizaje (DUA), para promover el fortalecimiento de la comprensión oral en estudiantes ciegos y videntes del colegio OEA IED, sede B. Desde una perspectiva cualitativa de investigación acción-pedagógica, este estudio indaga sobre el efecto de la propuesta pedagógica diseñada con base en los Lineamientos de Ciencias Naturales y Educación Ambiental, desde el tema "Los animales". Se desarrollaron cinco interacciones mediadas por los principios del DUA, que corresponden a: múltiples formas de representación, de expresión y de implicación, conduciendo a que los estudiantes vivencien cada actividad, bajo la óptica de la percepción multisensorial. El estudio se realiza con 32 estudiantes videntes y uno ciego, pertenecientes al curso 102. En un cuestionario inicial se evidencia la dificultad en comprensión oral, literal e inferencial; posterior a la implementación de la propuesta, se observa en el cuestionario final un avance significativo en los procesos de comprensión de todos los estudiantes y, especialmente, en el niño ciego congénito. Como resultado, se confirma la importancia de una educación inclusiva, haciendo énfasis en el estudiante ciego quien, por su discapacidad, requiere de apoyos para garantizar el acceso a la información y al aprendizaje frente a la comprensión, posibilitando experiencias en las diferentes áreas curriculares para todos los estudiantes y promoviendo el aprendizaje colaborativo.
La reunión como herramienta de gestión del desarrollo educacional
Authors: Saavedra Castellanos Andrés
Published: December 2019

El artí­culo aborda las bases teóricas de la reunión. Su novedad radica en la presentación de los elementos a tener en cuenta para convertirla en una herramienta de gestión del desarrollo educacional. En tal sentido, se definen los niveles de participación que tienen lugar en las reuniones, según el tipo y forma de realización. Unido a ello, se precisan las relaciones que deben establecerse entre participación, potenciación de competencias profesionales y acuerdos. Este trabajo es producto de la experiencia del autor en la dirección de proyectos de investigación, asesorí­as y capacitaciones desarrolladas con docentes y directivos en Cuba y Latinoamérica. Es un punto de vista que se pone a consideración de investigadores, docentes, especialistas y profesionales para su debate y discusión.
A Decorated Jar of the Byzantine Period in the Museo Egizio, Turin (Suppl. 15626)
Authors: Incordino Ilaria , Facchetti Federica
Published: December 2019

The article analyses a previously unpublished painted jar from the Byzantine Period discovered by Ernesto Schiaparelli at Asyut, possibly in 1911, and presently kept at the Museo Egizio, Turin (S. 15626). The distinctive female figure represented on the upper half of the body of the vessel is rather rare in the Byzantine repertoire. The author compares it with similar figures found on different supports and in different contexts. Notably, she highlights parallels with painted pottery from the monastery of Abba Nefer the Hermit at Manqabad, as well as in pottery assemblages from Kellia, Saqqara, Esna, Tebtynis, Deir el Bachit (West Thebes), and especially towns in Middle Egypt such as Amarna (Kom el-Nana), El-Ashmunein, Antinoopolis and Wadi Sarga. The probably non-religious female figure may be an instance of the well-known tendency in Byzantine Egypt to draw on the Hellenistic repertoire, especially in depictions of figures of prosperity and good luck, which would have been easily recognizable by both Christians and pagans.

ملخص البحث:

حلل المقالة إناء ملون لم يتم نشره من قبل ويعود إلى العصر البيزنطي، إكتشفه إرنستو سكياباريلي في أسيوط، على الأرجح في عام 1911، محفوظ حالياً في المتحف المصري بتورينو (S. 15626). الشكل الأنثوي المميز المعروض في النصف العلوي من جسم الإناء نادر جداً ضمن مجموعات أعمال العصر البيزنطي. يقارن المؤلف الشكل الموجود على الجزء العلوي من الإناء بأشكال متشابهة موجودة على أدوات مختلفة. تجدر الإشارة إلى أن الشكل يُبرز أوجه التشابه مع الفخار الملون بدير الناسك أبو نفر في منقباد، وكذلك في مجموعات فخارية موجودة في منطقة كيليا وسقارة وإسنا وتبتنيس ودير البشت (غرب طيبة)، وبشكل خاص في مدن مصر الوسطى مثل العمارنة (كوم النعناع) والأشمونين وانطيونوبوليس ووادي سرجة. ربما يكون شكل الشخصية الأنثوية غير الديني مثالاً على النزعة المعروفة في مصر البيزنطية من خلال الإرتكاز على مجموعة أعمال العصر الهلنستي، لا سيما في تصوير أشكال الرخاء والحظ السعيد التي كان يمكن التعرف عليها بسهولة لكلٍ من المسيحيين والوثنيين.
Formación del discurso en salud mental en la primera mitad del siglo XX
Authors: Mojica Perilla Mónica , Cadena Afanador Laura Del Pilar
Published: December 2019

La formación del discurso en salud mental durante la primera mitad del siglo XX tiene en el Movimiento de Higiene Mental y en el Comité Nacional de Higiene Mental sus principales influencias. Como depositarios de un estilo de pensamiento biomédico, los dos entes mencionados tomaron la vocería en el campo de la salud mental, el cual para la época bajo estudio adolecía de una clara diferenciación conceptual. Con el objeto de comprender la influencia que ejerció este estilo de pensamiento en la formación del discurso en salud mental durante la primera mitad del siglo XX, se desarrollo una revisión de literatura de la época, empleando para tal fin una propuesta teórica que combinó el análisis del discurso de Michel Foucault y la sociología del conocimiento de Ludwik Fleck. Los resultados evidencian una hegemonía del estilo de pensamiento biomédico para abordar la salud mental, representada principalmente en el empleo de la prevención como estrategia de trabajo; de igual forma se constató que fueron los médicos, psiquiatras y salubristas de la época quienes asumieron para sí, como colectivo de pensamiento, la autoridad para hablar y actuar sobre la salud mental de la población, relegando a un segundo plano otros colectivos de pensamiento.[Mojica-Perilla M, Cadena-Afanador LP. Formación del discurso en salud mental en la primera mitad del siglo XX. MedUNAB 2014; 16(3):118-126]
Analisis Kinerja Keuangan dengan Metode Economic Value-Added pada Studi Kasus Perusahaan Subsektor Pertambangan Minyak dan Gas Bumi yang Terdaftar di Indeks Saham Syariah Indonesia (ISSI)
Authors: Fatmasari Endah , Dwiyanto Bambang Sugeng
Published: December 2019

Oil and gas are non-renewable natural resources, whick means they can be exhausted within a certain periode of time, if no new reserves of oil and natural gas resources are found. Energy, especially oil and gas, is very limited amount, but the world’s needs for oil and gas are currently increasing, so making investments in the oil and gas mining subsector will be an attractive choice for investors. World demand of oil and gas increases, while the limited its availability in each country has caused fluctuations in its exports and imports. They face a difficult assessment of the company performance in this subsector. Therefore, we need an analysis of the financial performance in oil and gas mining subsector companies as a tool to assess how the performance of the in this area. Economic value-added (EVA) method is one of the right measurement tools to assess the performance of companies in the mining sector. The aim of this study is to determine the financial performance of companies by using the EVA (economic value-added) method in the oil and gas subsector companies listed on the ISSI (Indonesian Sharia Stock Index) in period 2013-2017. The calculation of EVA value of a company is preceded by determining the value of Net Operating Profit After Tax (NOPAT), Weighted Average Cost of Capital (WACC), capital charges (CC), and invested capital (IC) from data that has been collected in the secondary sources. Four companies in oil and gas mining subsector listed on the Indonesia Sharia Stock Index (ISSI) were analyzed in this research. The results showed that two companies have positive EVA, while rest of two companies have positive and negatif EVA in certain years. A positive EVA means that there is an economic added-value to the company.
Feminismo de Estado pós 2016: o contexto importa?
Authors: Belançon Milena Cristina
Published: December 2019

A ocupação de cargos na burocracia estatal foi um repertório de interação ativado por diversos movimentos sociais brasileiros, principalmente a partir da redemocratização, para que políticas públicas fossem colocadas em pauta no Estado. O movimento feminista foi um grande entusiasta desse repertório, logrando resultados bastante interessantes para se pensar a relação entre movimento social e Estado, e constitui o objeto deste trabalho. A partir de um levantamento histórico acerca da institucionalização do movimento feminista, recuperamos alguns instrumentos analíticos sugeridos para se abordar o contexto político. Desse modo, buscamos traçar uma sistematização de contribuições recentes, que foram demandadas pela realidade brasileira para medir o que não é apenas conjuntural e perene, mas também os resultados que perduram ao longo do tempo.
Mulheres pomeranas em movimento
Authors: Ulrich Claudete Beise , Koeler Edineia , Foerste Erineu
Published: December 2019

O artigo objetiva refletir sobre o protagonismo de mulheres pomeranas em movimentos sociais de transformação no município de Santa Maria de Jetibá, estado do Espírito Santo, partindo de uma problemática básica: em quais movimentos as mulheres pomeranas estão envolvidas e como a atuação delas constitui-se em desafio coletivo para elas mesmas e para todo Povo Tradicional Pomerano, que se encontra há 160 anos em terras capixabas? O artigo situa historicamente a chegada dos/as pomeranos./as nas terras capixabas. Aponta, então, para o protagonismo das mulheres pomeranas, através das narrativas de Selene e Gisela, no fortalecimento da luta coletiva por direito ao uso sustentável da terra, a partir da agricultura orgânica e agroecológica, objetivando saúde, alimentação saudável e uma educação que considere a cultura camponesa pomerana.
Hashtagit merkityksien rakentajina suomenkielisissä Instagram-päivityksissä
Authors: Rosenberg Jutta
Published: December 2019

This article examines ways in which Finnish Instagram users employ hashtags in their posts. Hashtags are not used only to link posts with the same tag together but also to guide readers ́ interpretations. The research material consists of 1,500 Instagram posts by private Instagram users with open accounts who have written their updates mainly in Finnish language. Findings indicate that the Finnish users employ hashtags 1) as topic tags, to highlight the subject and theme of the post; 2) as additions, to provide the necessary information for the interpretation of the post; and 3) as evaluative meta comments regarding the emotions connected with the post, the values of the writer and the tone of the post. The study has implications for the understanding of everyday construction of meaning in social media.
Kieltenopetus vuosiluokilla 1–3: Miten oppilaat siihen suhtautuvat ja mitä tuloksia sillä saavutetaan puolen vuoden opiskelun aikana?
Authors: Inha Karoliina , Huhta Ari
Published: December 2019

As of January 2020, all Finnish pupils are to start their foreign language studies in the first grade. This study examined the effects of early language teaching by comparing pupils in grades 1, 2 and 3. The pupils had started studying English in August 2017 and had all had roughly the same number of English lessons by the time of the study in early 2018. The study examined pupils’ attitudes towards English and studying English as well as how pupils use English in their free time. Pupils also self-assessed their English skills and completed vocabulary and text segmentation tasks. The results show that the pupils had an overall positive attitude towards English and language learning. Analyses of pupils’ language skills and extramural use of English revealed statistically significant differences between 1st, 2nd and 3rd graders. Findings and their possible explanations are discussed.
REFLECTIVE THINKING STRATEGIES FOR DEVELOPING EFL LITERARY READING SKILLS AND METACOGNITIVE READING AWARENESS
Authors: Alian Eman Mahmoud
Published: December 2019

The present study is aimed at examining the effect of reflective thinking strategies on developing literary reading skills and metacognitive reading awareness of the EFL student teachers. The study adopted the quasi-experimental design. One experimental group of 40 major English students at the third-year Faculty of Education, Zagazig University in Egypt, participated in the study. The treatment conducted in fourteen sessions through teaching King Lear drama by Shakespeare. The utilized instruments included a literary reading test that was developed and used as a pre-post test and a metacognitive reading awareness scale, which was also designed by the researcher and approved by the jury members. Parametric statistical calculations have used for data analysis through the SPSS program. Results revealed that reflective thinking had a positive effect on developing literacy reading skills and metacognitive reading awareness of the EFL student teachers.
DYSFUNCTIONAL SEMANTIC ROLE OF LANGUAGE IN LITERARY TEXTS: A CASE STUDY ON HAROLD PINTER’S MOUNTAIN LANGUAGE
Authors: Saeed Yadgar Faeq , Muhammed Areen Ahmed
Published: December 2019

Language and literature are two inseparable subjects, one of which cannot be fully functional with the absence of the second part. This article shows the dysfunction of semantics in Harold Pinter’s Mountain Language. For many years, scholars and linguists work separately on different cases regarding literary texts or linguistics obstacles. From this paper, a new path will be saved for future references and works to bring both cases together and show their roles on one another. Moreover, literary works pay less attention to grammatical rules and plenty of dysfunctional languages can be examined and seen. In addition, several external factors can be the obstacle of using functional and accurate language use semantically and systematically. Moreover, political or social violence have become major points in many literary topics in the modern era. This study deals with theoretical aspects of society starting from family up to community and government. Additionally, the absence of semantics in the language of this drama is not neglected arbitrarily; whilst, there is a loop of violence. There are some basic theories related to the topic that this paper will examine. It includes the theory of Grice’s maxims (Gricean maxims) and the role of semantics when it comes to politics and power.  Finally, the paper alienates all the curtains and shows the role of power, gender differences, class status, and diversity on language use in many areas.
ANGUISH IN ALEXANDER DUMAS’ NOVEL THE COUNT OF MONTE CRISTO
Authors: Hidayati Hidayati , Arifuddin Arifuddin , Z. Zainab M , Aflina Aflina
Published: December 2019

The research is conducted based on the novel The Count of Monte Cristo, written by a French writer Alexander Dumas. The focus goes to anguish experienced by the protagonist of the novel, Edmond Dante, a young and handsome sailor with a brilliant prospects in career making him plunged into life of anguish. He is arrested for no reason, sent to jail with inhuman treatment. Descriptive qualitative method is applied to reveal that literary works are mirrors of all the occurrences in society. This is in line with the sociology of literature also implemented here as the approach to further analysis of the subject matters having three aspects to be used as a literary research guidelines: social contexts of the author, already showed by the author, literature as the reflection of society, revealed through the text tending to social reality and functions of literature as entertainer or remodel of society, exposed through the responses of the readers. The results show that the novel contains anguish subdivided into Non-procedural Arrest and Inhuman Imprisonment covering the whole study.
Application Design of the Medicines Usage Prediction Based on Backpropagation Neural Network Method and PHP
Authors: Dharmaadi I Putu Arya , Sasmita Gusti Made Arya
Published: December 2019

The development of information technology makes many organizations utilizing it in their business process. For example, hospitals use certain information systems in medicine management. We observe that most medicines applications do not provide the drug usage prediction feature so that this situation causes the hospital staff being difficult in providing enough medicines. Therefore, in this experimental research, we developed an application in the form of a simple design for helping the hospitals in predicting daily medicine usage. This application also provides medicines stock management and doctor diagnosis features. The Brainy library is used to facilitate implementing the backpropagation neural network method in PHP programming language. We choose PHP because this server script is widely used in information system development. We demonstrated that the mock-up as the result of this development is able to work properly. For further study, we suggest expanding this mock-up become a full hospital information system that covers many functions in medical centers.
Análisis de Sensibilidad aplicado a modelos de crecimiento urbano basados en autómatas celulares de estructura irregular
Authors: Urgilez Clavijo Andrea , Gómez Delgado Montserrat , Barreira González Pablo
Published: December 2019

En el presente trabajo se aplica un Análisis de Sensibilidad (AS), como parte de un proceso de validación, sobre un modelo de simulación del crecimiento urbano basado en Autómatas Celulares (AC) de estructura irregular (MUGICA, Model for Urban Growth simulation using an Irregular Celular Automata). Este modelo ha sido desarrollado para simular el crecimiento urbano de tres municipios pertenecientes a un importante corredor urbano-industrial (Corredor del Henares) localizado en la zona central peninsular de España. Si bien la metodología utilizada en este trabajo ya ha sido aplicada en modelos basados en una estructura raster, se pretende comprobar su viabilidad en un modelo de estructura irregular como MUGICA, el cual emplea la parcela catastral como unidad de referencia. El objetivo es explorar el grado de influencia de cada uno de los factores en los resultados del modelo, de manera individual y en sus diferentes combinaciones. Para ello se realiza una eliminación sucesiva de los factores con el fin de evaluar si la ausencia de uno o varios de ellos supone una alteración significativa de los resultados. Los resultados muestran, en primer lugar, la viabilidad de la aplicación de esta metodología en este tipo de entorno irregular. Por otro lado, se ha podido constatar la gran influencia de los factores accesibilidad y aptitud en el desarrollo de suelo urbano, como sería de esperar en un modelo de estas características.
Análisis del conocimiento ecológico tradicional y factores socioculturales sobre huertos familiares en el Altiplano Central Mexicano
Authors: García Flores José Carmen , Gutiérrez Cedillo Jesús Gastón , Balderas Plata Miguel Ángel , Juan Pérez José Isabel
Published: December 2019

El objetivo fue analizar mediante investigación participativa el conocimiento ecológico tradicional y los factores socioculturales asociados con los huertos familiares en tres localidades rurales del Altiplano Central Mexicano. Las etapas metodológicas fueron: Estudio del conocimiento ecológico tradicional sobre huertos familiares; Análisis de las prácticas de manejo como expresiones del conocimiento local; y Análisis de los factores socioculturales y ambientales vinculados con el conocimiento. El enfoque participativo propició la interpretación y discusión colectiva de información acerca del conocimiento, las prácticas de manejo, el uso de las plantas, así como la valoración sociocultural de estos agroecosistemas. El conocimiento ecológico tradicional sobre huertos familiares es resultado de la experiencia empírica de las personas a lo largo de su vida como campesinos, en él están intrínsecamente relacionadas la comprensión social, cultural y ambiental del entorno. Los conocimientos aplicados en el manejo de estos agroecosistemas favorecen el aprovechamiento de las especies y brindan diversos beneficios, por esta razón en el ámbito científico la investigación destaca la importancia del conocimiento ecológico tradicional. Se concluye que a partir de los conocimientos locales, las personas interrelacionan condiciones de su contexto para el mantenimiento de los huertos familiares y la adaptación de la agrobiodiversidad.
Movilidad residencial en la Región Metropolitana de Córdoba, 2005-2010
Authors: Molinatti Florencia
Published: December 2019

El objetivo de este trabajo es analizar la movilidad residencial dentro de la Región Metropolitana de Córdoba, particularmente los cambios de municipio de residencia en el período 2005-2010. Los datos provienen del Censo Nacional de Población, Hogares y Vivienda 2010 y se utiliza la información sobre el municipio de residencia habitual y en una fecha fija anterior y se calculan tasas de ingresos y egresos a los diferentes municipios que componen la región, como así también tasas netas de movilidad residencial, según el tamaño de población y la distancia respecto del centro metropolitano. También se estima la intensidad de la movilidad residencial de acuerdo a las características de los individuos y hogares que protagonizaron dichos desplazamientos. Los municipios de menor tamaño y ubicados a una distancia intermedia exhiben las mayores tasas netas de movilidad residencial, y la mayor intensidad se registra entre los adultos de entre 30 y 39 años con mayores niveles educativos y en los niños de 5 a 9 años, que residen en hogares que se encuentran en la etapa inicial de la conformación del nuevo hogar familiar. Los resultados obtenidos dan cuenta del importante papel que tiene la movilidad residencial en la configuración de la nueva dinámica socio-territorial de la región.
Dinámicas recientes de la población en municipios rurales de la Axarquía malagueña con elevada presencia de extranjeros (2003/2017).
Authors: Natera Rivas Juan José , Batista Zamora Ana Esther
Published: December 2019

La inmigración extranjera recibida por 22 pequeños municipios rurales de la comarca malagueña de la Axarquía ha sido determinante en la evolución de sus contingentes poblacionales en el periodo 2003/2017. Se trata de una inmigración mayoritariamente proveniente de la Unión Europea, envejecida, y asimilable al grupo de inmigrantes con motivaciones básicamente residenciales. A partir de la información obtenida de la Estadística del Padrón Continuo, con un nivel de desagregación espacial correspondiente a la entidad de población, mostramos cómo las dinámicas de distribución espacial son diferentes según el grupo de población considerado: aumento de la dispersión espacial de los españoles entre 2013 y 2017 –con mantenimiento de la situación entre 2013 y 2017; incremento de la concentración de los extranjeros provenientes de la Unión Europea en el periodo 2003/2013, y desconcentración relativa entre 2013 y 2017.
Значимость поддержания водородного показателя в организме коров для профилактики метаболических нарушений и повышения молочной продуктивностиодуктивности
Authors: Луговой Михаил Михайлович , Азарнова Татьяна Олеговна , Подольников Валерий Егорович , Луговая Инесса Сергеевна
Published: December 2019

Реакция среды рубца коров — важный показатель, который определяет динамику ферментативных процессов, образование метаболитов, их всасывание и использование в организме. Определена взаимосвязь между молочной продуктивностью коров и уровнем pH кормов и мочи. Для выявления признаков ацидоза изучено значение pH в силосной и сенажной траншеях в одном из колхозов Калужской области. Для обнаружения физиологических закономерностей течения биохимических процессов в организме измерены значения pH мочи у 40 подопытных животных, а также уровень среднесуточной продуктивности по результатам контрольной дойки. Коровы, получавшие «не кислый» силос (pH 4,22) и сенаж (pH 4,96) имели физиологически нормальное значение водородного показателя в моче (среднесуточная молочная продуктивность — 21,95 ± 0,94 кг). Коровы, получавшие корм с более кислым значением pH, уровень которого на 10,7 % был ниже (среднесуточная молочная продуктивность —19,35 ± 0,98 кг), имели признаки хронического ацидоза. Снижение молочной продуктивности в этой группе на 24,1 % является следствием алиментарных метаболических заболеваний. Снижение pH мочи является диагностическим методом для выявления признаков хронического ацидоза в организме коров. Предложены меры профилактики алиментарных нарушений обмена веществ у молочных коров.
The impact of performance analysis on the financial management and control at public universities in Bosnia and Herzegovina Federation
Authors: Čergić Fuad , Kozarević Emira
Published: December 2019

Organizations in today’s extremely competitive environment need to devote significant time, energy as well as human and financial resources to the measurement of their efficiency, in order to increase their profit, reduce costs, better plan their assets and manage their budgets, as well as to improve budget controls and risk assessment. Therefore, they need performance models, including the Balanced Scorecard. Primarily intended for profit organizations, the Balanced Scorecard is today used in the public sector, as well. This paper presents the research into the utilization of the Balanced Scorecard in the public sector, examining whether the performance of higher education institutions may be improved by the design and utilization of the Balanced Scorecard model.
The effect of corporate social disclosure practice on reporting quality
Authors: Dropulić Ivana , Čular Marko
Published: December 2019

This research is striving to provide an insight into the importance of Corporate Social Responsibility (CSR) for the insurance sector while aiming to examine various corporate social responsibility initiatives undertaken by insurance companies in Croatia. There is a broad range of potential benefits from CSR for insurance companies such as long-term sustainability and profitability, yet only several research studies on CSR practices have thus far been conducted on the insurance sector. Hence, the purpose of this research is to determine the level of CSR reporting for insurance and reinsurance companies in Croatia and its impact on reporting quality. The empirical research is based on online reporting of six aspects of corporate social responsibility to determine Corporate Social Disclosure Index (CSDI). Reporting quality is measured with Disclosure Quality Index of annual report (DQI) which is structured in five phases. This research includes all 24 insurance and reinsurance companies in Croatia and the research findings show that all insurance and reinsurance companies in Croatia publish information at least concerning two aspects of CSR. It was found that they are the most transparent regarding the human resources aspect of CSR activities and the least transparent concerning environmental aspect of CSR activities. The overall level of CSR disclosure for insurance sector in Croatia is quite low, so we can conclude that insurance and reinsurance companies in Croatia do not have a high level of CSR online disclosure. Considering the issue of reporting quality, insurance and reinsurance companies have an average quality of annual report (AR), measured by DQI of annual report. According to research findings, CSR reporting on the Internet is positively associated with DQI which leads to the conclusion that more socially responsible insurance and reinsurance companies provide annual reports of a more superior quality. Business and society interact and exert a mutual influence through their specific objectives and goals. Consequently, the link between business and society is indisputable. Companies, as one of the key segments of a society, can achieve a number of economic benefits, such as superior business results and considerable competitive advantage if they implement CSR and if they provide high quality information through their annual reports. Moreover, society benefits from socially responsible companies as it enjoys better care both for its own well-being and for that of the environment.
The importance of partnerships in supply chains
Authors: Kmetec Anja , Rosi Bojan , Mlaker Kač Sonja
Published: December 2019

The article deals with an overview of various theories and studies examining the concepts of partnerships, relationships and strategic alliances. We present various perspectives and theories dealing with these concepts, in connection and interdependence with the supply chain and the supply chain management. In conclusion, we try to establish a model to become the basis for our further study of strategic alliances and their strengths.
Dynamics of urban population in Ukraine at beginning of 21 century
Authors: Kobzyak R.
Published: December 2019

The change of number of Ukrainian cities’ population was analyzed on the basis of statistical data of Ukrainian census in 2001 and data of State Statistical Committee of Ukraine. There was discovered the difference of movements’ index of Ukrainian cities’ population. The groups of cities’ were marked by the change of their inhabitants’ quantity. The distribution of Ukrainian regions was done on the basis of annual index of population’s movement. Key words: change of number, movements’ index, cities.
Genesis and evolution of sod-podzol soils with underling compact carbonates
Authors: Saliuk M.
Published: December 2019

Modern researches of genetic nature of sod-podzol soils with underling carbonates are considered in the article. They are erected to evolutional row from rendzina to sod-podzol soils and forming soils on the layer of water-glacial with were put on carbonates rocks. Key words: genesis, evolution, sod-podzol, soils, carbonic rocks.
The hotel industry in Lviv: modern trends of progress
Authors: Stetsyuk O.
Published: December 2019

The hotel industry of Lviv region and the main tourist centre of the Western region of Ukraine – Lviv are investigated. The basic indicators of development of hotel services in Lviv area is analyzed during 2000-2009. The main stream of improvement of the regional hotel industry is expected, including for successful carrying out of the European Football Championship in 2012. Key words: hotel industry, tourist infrastructure, hotel, hotel services, quantity of visitors, capacity of hotels, coefficient of capacity of the enterprises, the European Football Championship.
Ethnofestival tourism the Lviv Region: thematic structure and spatialtemporal characteristics of the organization
Authors: Topornycka M.
Published: December 2019

The ethnofestivals in the Lviv Region have been systematized on the thematic approach. The spatial-temporal characteristics of the ethnofestival tourism in the region have been descibed. The specific recommendations for future development and promoting of festival tourism in Lviv Region have been proposed. Key words: ethnic tourism, ethnofestival, ethnofestival tourism, festivals classification, geography of ethnofestival tourism.
DINÁMICAS DEL PRECIO DEL SUELO DE LA CIUDAD DE RESISTENCIA (CHACO-ARGENTINA). APROXIMACIONES A UNA LÓGICA FRAGMENTARIA
Authors: Galvaliz Sebastián A.
Published: December 2019

El siguiente artículo da cuenta de las primeras aproximaciones en la lógica del mercado de suelo urbano (MSU) en el Área Metropolitana del Gran Resistencia (AMGR); la configuración de precios en base a la localización y la relación del mismo con la configuración de las ciudades actuales. Se tomará como área testigo un sector del Nor-Este de la ciudad de Resistencia-Chaco
INSTRUMENTOS DE LA POLITICA DE ORDENAMIENTO AMBIENTAL DEL TERRITORIO. UN ESTUDIO DEL MARCO NORMATIVO EN LA ARGENTINA CONTEMPORÁNEA. PI 18C004 SGCyT UNNE
Authors: Romagnoli Venettia , Fogar Sandra
Published: December 2019

El presente trabajo tiene como principal propósito difundir el proceso de formulación y objetivos, como así también los primeros avances de un proyecto de investigación acreditado por la Secretaria General de Ciencia y Técnica de la UNNE, denominado “Instrumentos de la política de ordenamiento ambiental del territorio. Un estudio del marco normativo en la argentina contemporánea”, que tiene por objetivo generar un avance en la producción de conocimiento e iniciar acciones de vinculación y retroalimentación entre las actividades de formación de posgrado e investigación, proponiendo como lugar específico de trabajo dentro de la Facultad de Arquitectura y Urbanismo de la UNNE, a la MGATU