bluuebunny/crossref_metadata_2025 huggingface dataset:
P‐16.1: Study of Active Matrix Circuits Design for Micro‐LED displays and Visible Light Communications
Authors: Li Weizeng , Tong Caiyu , Liu Xinyi , Wang Ruoning , Liu Zhaojun
Published: October 2019

Because Micro‐LED is the current‐driven device, there are usually two types of the matrix driving circuit, passive matrix driving circuit, and active matrix driving circuit. Comparing these two driving circuits, the active driving circuit can achieve better brightness uniformity, higher contrast and lower contrast. Therefore, most of Micro‐LEDs use active matrix driving circuit. In this paper, a study of active matrix circuit design for Micro‐LED displays and beyond display applications such as visible light communication will be reported. The pixel circuit integrates two parts of VLC together, the emitter and the receiver. When the LED is on, it can work as the emitter of VLC. When the LED is off, the photodetector can work as the receiver of the VLC. This can offer more varieties of the application, such as face‐to‐face data transmission, under‐screen fingerprint identification and so on.
P‐16.6: Capacitance Simulation of OGM Touch Screen and its Influencing Factors
Authors: Pang Bin , Guo Zongjie , Xie Xiaodong , Xu Zouming
Published: October 2019

In this paper, the mutual capacitance of OGM capacitive touch screen is simulated, and the influence of various design parameters on the mutual capacitance of OGM touch screen is studied. First, the effect of the thickness of insulating layers on the capacitance is investigated. Then, the influence of the channel width and the cutting mode of metal mesh on the capacitance is discussed, and the relationship between the mutual capacitance and the equivalent cross area between Tx and Rx electrodes is further derived. Finally, the touch sensitivity of our OGM patterns is verified. Through the summary of the influencing factors on mutual capacitance, it can provide reference for subsequent product development to meet the growing market demand.
Ga‐Based Liquid Metal Micro/Nanoparticles: Recent Advances and Applications
Authors: Song Hyunsun , Kim Taekyung , Kang Seohyun , Jin Haneul , Lee Kwangyeol , Yoon Hyo Jae
Published: October 2019

Liquid metals are emerging as fluidic inorganic materials in various research fields. Micro‐ and nanoparticles of Ga and its alloys have received particular attention in the last decade due to their non toxicity and accessibility in ambient conditions as well as their interesting chemical, physical, mechanical, and electrical properties. Unique features such as a fluidic nature and self‐passivating oxide skin make Ga‐based liquid metal particles (LMPs) distinguishable from conventional inorganic particles in the context of synthesis and applications. Here, recent advances in the bottom‐up and top‐down synthetic methods of Ga‐based LMPs, their physicochemical properties, and their applications are summarized. Finally, the current status of the LMPs is highlighted and perspectives on future directions are also provided.
Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts
Authors: Ahola-Olli Ari V. , Mustelin Linda , Kalimeri Maria , Kettunen Johannes , Jokelainen Jari , Auvinen Juha , Puukka Katri , Havulinna Aki S. , Lehtimäki Terho , Kähönen Mika , Juonala Markus , Keinänen-Kiukaanniemi Sirkka , Salomaa Veikko , Perola Markus , Järvelin Marjo-Riitta , Ala-Korpela Mika , Raitakari Olli , Würtz Peter
Published: October 2019

Aims/hypothesis

Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults.

Methods

NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finnish observational cohorts (baseline age 24–45 years). Associations between baseline metabolites and risk of developing diabetes during 8–15 years of follow-up (392 incident cases) were adjusted for sex, age, BMI and fasting glucose. Prospective metabolite associations were also tested with fasting glucose, 2 h glucose and HOMA-IR at follow-up.

Results

Out of 229 metabolic measures, 113 were associated with incident type 2 diabetes in meta-analysis of the four cohorts (ORs per 1 SD: 0.59–1.50; p< 0.0009). Among the strongest biomarkers of diabetes risk were branched-chain and aromatic amino acids (OR 1.31–1.33) and triacylglycerol within VLDL particles (OR 1.33–1.50), as well as linoleic n-6 fatty acid (OR 0.75) and non-esterified cholesterol in large HDL particles (OR 0.59). The metabolic biomarkers were more strongly associated with deterioration in post-load glucose and insulin resistance than with future fasting hyperglycaemia. A multi-metabolite score comprised of phenylalanine, non-esterified cholesterol in large HDL and the ratio of cholesteryl ester to total lipid in large VLDL was associated with future diabetes risk (OR 10.1 comparing individuals in upper vs lower fifth of the multi-metabolite score) in one of the cohorts (mean age 31 years).

Conclusions/interpretation

Metabolic biomarkers across multiple molecular pathways are already predictive of the long-term risk of diabetes in young adults. Comprehensive metabolic profiling may help to target preventive interventions for young asymptomatic individuals at increased risk.
Rationalizing predictably irrational choices: the social capital synthesis
Authors: Robison Lindon J. , Oliver Jeffrey R.
Published: October 2019

This paper presents a synthesis of the main characteristics of neoclassical, behavioral, and socioeconomic models. The main characteristics of this synthesis is that it includes social capital-produced relational goods whose value and meaning depend on their connections to people. We contrast relational goods with commodities. Then, we examine whether the synthesis can resolve some of the sometimes conflicting explanations and predictions of economic exchange models. Finally, we apply the synthesis to rural development and find it provides useful explanations and recommendations.
Stabilizing diode laser to 1 Hz-level Allan deviation with atomic spectroscopy for Rb four-level active optical frequency standard
Authors: Chang Pengyuan , Zhang Shengnan , Shang Haosen , Chen Jingbiao
Published: October 2019

We achieve a compact ultra-stable 420 nm blue diode laser system by immediately stabilizing the laser on the hyperfine transition line of Rb atom. The Allan deviation of the residual error signal reaches 1 Hz-level Allan deviation within 1 s averaging time, and the fractional frequency Allan deviation is$$1.4\times 10^{-15}/\sqrt{\tau }$$1.4×10-15/τ, which shows the best result of frequency-stabilized lasers based on the atomic spectroscopy without Pound–Drever–Hall (PDH) system. The signal-to-noise ratio of the atomic spectroscopy is evaluated to be 3,000,000 from the Allan deviation formula, which is the highest record, to the best of our knowledge. The frequency noise suppression characterization is demonstrated and the maximal noise suppression can be near 40 dB at 6 Hz. As a good candidate of pumping source, the ultra-stable 420 nm diode laser is successfully used in our Rb four-level active optical frequency standard system. The method can be easily extended to other wavelengths ultra-stable lasers with a Allan deviation of$$10^{-15}$$10-15level retaining an atomic reference with low cost and low complexity while in the absence of an expensive and complicated PDH system.
Asian water tower evinced in total column water vapor: a comparison among multiple satellite and reanalysis data sets
Authors: Zhao Yin , Zhou Tianjun
Published: October 2019

The total column water vapor (TCWV) over the Tibetan Plateau (TP) is one important indicator of the Asian water tower, and the changes in the TCWV are vital to the climate and ecosystem in downstream regions. However, the observational data is insufficient to understand the changes in the TCWV due to the high elevation of the TP. Satellite and reanalysis data can be used as substitutes, but their quality needs to be evaluated. In this study, based on a homogenized radiosonde data set, a comprehensive evaluation of the TCWV over the TP derived from two satellite data sets (AIRS-only and AIRS/AMSU) and seven existing reanalysis data sets (MERRA, MERRA2, NCEP1, NCEP2, CFSR, ERA-I, JRA55) is performed in the context of the climatology, annual cycle and interannual variability. Both satellite data sets reasonably reproduce the characteristics of the TCWV over the TP. All reanalysis data sets perform well in reproducing the annual mean climatology of the TCWV over the TP (R = 0.99), except for NCEP1 (R = 0.96) and NCEP2 (R = 0.92). ERA-I is more reliable in capturing the spatial pattern of the annual cycle (R = 0.94), while NCEP1 shows the lowest skill (R = 0.72). JRA55 performs best in capturing the features of the interannual coherent variation (EOF1, R = 0.97). The skill-weighted ensemble mean of the reanalysis data performs better than the unweighted ensemble mean and most of the single reanalysis data sets. The evaluation provides essential information on both the strengths and weaknesses of the major satellite and reanalysis data sets in measuring the total column water vapor over the TP.
Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer
Authors: Golob-Schwarzl Nicole , Wodlej Christina , Kleinegger Florian , Gogg-Kamerer Margit , Birkl-Toeglhofer Anna Maria , Petzold Johannes , Aigelsreiter Ariane , Thalhammer Michael , Park Young Nyun , Haybaeck Johannes
Published: October 2019

Background

Gallbladder cancer (GBC) is a rare neoplasia of the biliary tract with high mortality rates and poor prognosis. Signs and symptoms of GBC are not specific and often arise at late stage of disease. For this reason, diagnosis is typically made when the cancer is already in advanced stages, and prognosis for survival is less than 5 years in 90% of cases. Biomarkers to monitor disease progression and novel therapeutic alternative targets for these tumors are strongly required. Commonly, dysregulated protein synthesis contributes to carcinogenesis and cancer progression. In this case, protein synthesis directs translation of specific mRNAs, and, in turn, promotes cell survival, invasion, angiogenesis, and metastasis of tumors. In eukaryotes, protein synthesis is regulated at its initiation, which is a rate-limiting step involving eukaryotic translation initiation factors (eIFs). We hypothesize that eIFs represent crossroads in the development of GBC, and might serve as potential biomarkers. The study focus was the role of eIF6 (an anti-association factor for the ribosomal subunits) in GBC.

Methods

In human GBC samples, the expression of eIF6 was analyzed biochemically at the protein (immunohistochemistry, immunoblot analyses) and mRNA levels (qRT-PCR).

Results

High levels of eIF6 correlated with shorter overall survival in biliary tract cancer (BTC) patients (n = 28). Immunohistochemical data from tissue microarrays (n = 114) demonstrated significantly higher expression levels of eIF6 in GBC compared to non-neoplastic tissue. Higher eIF6 expression on protein (immunoblot) and mRNA (qRT-PCR) level was confirmed by analyzing fresh frozen GBC patient samples (n = 14). Depletion of eIF6 (using specific siRNA-mediated knockdown) in Mz-ChA-2 and TFK-1 cell lines inhibited cell proliferation and induced apoptosis.

Conclusion

Our data indicates that eIF6 overexpression plays a major role in the translational control of GBC, and indicates its potential as a new biomarker and therapeutic target in GBC.
Axial loading during MRI reveals insufficient effect of percutaneous interspinous implants (Aperius™ PerCLID™) on spinal canal area
Authors: Hjaltadottir Hrafnhildur , Hebelka Hanna , Molinder Caroline , Brisby Helena , Baranto Adad
Published: October 2019

Purpose

To evaluate the effect on the spinal canal at the treated and adjacent level(s), in patients treated for lumbar spinal stenosis (LSS) with percutaneous interspinous process device (IPD) Aperius™ or open decompressive surgery (ODS), using axial loading of the spine during MRI (alMRI).

Materials

Nineteen LSS patients (mean age 67 years, range 49–78) treated with IPDs in 29 spine levels and 13 LSS patients (mean age 63 years, range 46–76) operated with ODS in 22 spine levels were examined with alMRI pre- and 3 months postoperatively. Radiological effects were evaluated by measuring the dural sac cross-sectional area (DSCSA) and by morphological grading of nerve root affection.

Results

For the IPD group, no DSCSA increase was observed at the operated level (p = 0.42); however, a decrease was observed in adjacent levels (p = 0.05). No effect was seen regarding morphological grading (operated level: p = 0.71/adjacent level: p = 0.94). For the ODS group, beneficial effects were seen for the operated level, both regarding DSCSA (p < 0.001) and for morphological grading (p < 0.0001). No changes were seen for adjacent levels (DSCSA; p = 0.47/morphological grading: p = 0.95). Postoperatively, a significant difference between the groups existed at the operated level regarding both evaluated parameters (p < 0.003).

Conclusions

With the spine imaged in an axial loaded position, no significant radiological effects of an IPD could be detected postoperatively at the treated level, while increased DSCSA was displayed for the ODS group. In addition, reduced DSCSA in adjacent levels was detected for the IPD group. Thus, the beneficial effects of IPD implants on the spinal canal must be questioned.

Graphic abstract

These slides can be retrieved under Electronic Supplementary Material.
How do drivers merge heavy goods vehicles onto freeways? A semi-structured interview unveiling needs for communication and support
Authors: Dreger Felix A. , de Winter Joost C. F. , Happee Riender
Published: October 2019

Freeway merging of heavy goods vehicles (HGV) is a safety–critical manoeuvre. However, at present, it is largely unknown how HGV drivers perceive and execute the merging manoeuvre, and how current advanced driver support and automation systems (ADAS) contribute. We performed semi-structured in-depth interviews with 15 HGV drivers to assess their visual and cognitive processes while merging, interactions with other road users, and attitudes towards ADAS as a basis for future support and automation system design. Results show that the reported execution of merging varies substantially between drivers. Drivers reported reliance on courtesy of other traffic but stated that car drivers are often causing conflicts, whereas other HGV drivers are more cooperative. Current ADAS were perceived as useful in general, with remarks about misuse and abundance of systems. We recommend the introduction of driver support and automation systems which facilitate cooperative behaviour and support effective communication.
VLA observations of 20 FR II radio sources at 8.4 GHz
Authors: Fernini Ilias
Published: October 2019

We report the last observational paper of hot spots for 20 Fanaroff-Riley class II (FR II) sources. These sources are part of a large sample of 98 FR II to study the unification scheme of FR II radio galaxies (RGs) and quasars (QSRs) using the hotspots (HSs) location and morphology. High-resolution VLA observations at 8.4 GHz were conducted for the whole sample. The investigation of HSs properties in FR II radio sources is essential for a better understanding of the dynamics related to the objects and their impact on the surrounding environment. HSs were classified into edged and recessed types, where the former is located at a radio lobe’s outer edge, and the latter is embedded within the lobe. The present sub-sample contains 12 RGs and 8 QSRs. Radio contour maps for each source were presented using the VLA in its A and B configurations. In total, we have identified 18 HSs for these 20 radio sources. The 12 RGs possess 8 edged HSs and 2 recessed HSs. The 8 QSRs possess 6 edged HSs and 2 recessed HSs. Out of the 14 edged HSs, RGs and QSRs possess $\sim57\%$∼57% and $\sim43\%$∼43%, respectively. A thorough morphological discussion of the 20 sources with their HSs is presented in the present work.
A Drought Adaptation Management System for Groundwater Resources Based on Combined Drought Index and Vulnerability Analysis
Authors: Al Adaileh Haitham , Al Qinna Mohammed , Barta Károly , Al-Karablieh Emad , Rakonczai János , Alobeiaat Adel
Published: October 2019

Water scarcity is one of the largest global risks in terms of potential impact over the next decade as it affects every continent is manifested by partial or no satisfaction of expressed demand, economic competition for water quantity or quality, disputes between users, irreversible depletion of groundwater, and negative impacts on the environment. Jordanian water crises are exacerbating all of the time due to increased water demands derived from high population growth, sudden fluxes of refugees, economic development, and increased frequency of drought events. These forces stress the urgent need to develop drought adaptation planning based on vulnerability mapping correlated to prolonged weather events. The objective of this research is thus to generate a drought vulnerability map with an emphasis on the severity and probability of drought occurrence, and to propose adaption measures based on groundwater sector impact chain analysis by incorporating numerical scorings for exposure, sensitivity, and adaptive capacities at groundwater basin and Jordanian district levels. Drought impacts on groundwater basins were investigated based on measurements of severity and probability of drought occurrence, and drought exposure over the whole country computed by means of a combined drought index (CDI) that included the precipitation drought index, temperature drought index, and vegetation drought index from 1980 to 2017. Results indicated that drought in Jordan is characterised by a temporal and spatial variability regarding probability and severity. The most prolonged drought events range from mild to moderate, with long periods of exposure that may extend for up to 13 consecutive years. Due to high groundwater basin sensitivity and low adaptive capacity, the groundwater systems in Jordan are fragile and highly vulnerable to drought impacts, being subject to either reduction in quantity and/or deterioration in quality over time. The most vulnerable groundwater basins are the Azraq and Dead Sea regions, while Disi and Yarmouk are also highly vulnerable groundwater basins based on the weak enforcement of transboundary agreements. The proposed drought risk management system based on this research includes proactive and contingency plans enabled by policies and legal frameworks at the national level to ensure sustainable water resilience and governance.
Transformation by Fire: Changes in Funerary Customs from the Early Agricultural to Early Preclassic Period among Prehispanic Populations of Southern Arizona
Authors: Cerezo-Román Jessica I. , Watson James T.
Published: October 2019

We examine the changes in funerary rituals from the Early Agricultural period (2100 BC–AD 50) to the Early Preclassic period (AD 475–750) and how these changes concurrently reflect changes in social relationships between the dead, their families, and the community. The predominant mortuary ritual in the Early Agricultural period was inhumation, possibly emphasizing a variety of identity intersections of the dead and the mourners in the treatment of the body while creating collective memories and remembrances through shared ways of commemorating the dead. An innovation in funerary practices in the form of secondary cremation appeared in the Early Agricultural period and was slowly but broadly adopted, representing new social dynamics within the society. Thereafter, secondary cremation became the main funeral custom. During the Early Preclassic period, the variation in body position and the type and quantity of objects found with individuals decreased. It is possible that the vehicle for displaying different identity intersections changed and was not placed in the body, per se, as much as in previous periods. However, the transformation characteristics of these funeral rituals and the increase in community investment could have fostered the building or reinforcing of stronger social ties that highlighted a “collective identity.”
Policy entrepreneurship and the influence of the transnational financial industry in the EU reform of securitization
Authors: Montalbano Giuseppe
Published: October 2019

According to most of the literature available so far, international and European cross-border banks and investments firms are considered the primary beneficiaries of the CMU and related revitalization of securitization. Nevertheless, an in-depth analysis of the transnational financial industry lobbying and influence, in the light of the final agreement on the securitization reform package, is still missing. This paper intends to fill this gap in the story by assessing if, and to what extent, the alleged industry beneficiaries played an active role in shaping the regulatory agenda within the CMU project and its related outcomes. An in-depth analysis of corporate lobbying in the securitization reform is thus provided, by looking at the interactions between structural and political contextual factors in shaping private/public coalitions along the different stages of the EU policy-making process. As it is argued here, the policy entrepreneurship of the European securitization industry has been the key factor to explain the emergence of the EU regulatory approach and its legislative outcomes.
Assessing research participant preferences for receiving study results
Authors: Cook Sarah , Mayers Stephanie , Goggins Kathryn , Schlundt David , Bonnet Kemberlee , Williams Neely , Alcendor Donald , Barkin Shari
Published: October 2019

Introduction:

Dissemination of results to research participants is largely missing from the practices of most researchers. Few resources exist that describe best practices for disseminating information to this important stakeholder group.

Methods:

Four focus groups were conducted with a diverse group of individuals. All participants were part of a Patient-Centered Outcomes Research Institute-funded survey study. Focus groups aimed to identify participants’ preferences about receiving research results and their reactions to three different dissemination platforms.

Results:

Four focus groups with 37 participants were conducted, including: (1) adults with one comorbidity, at least a college education, and high socioeconomic status (SES); (2) adults with one comorbidity, less than a college education, and lower SES; (3) adults with low health literacy and/or numeracy; and (4) Black or African American adults. Participants discussed their preferences for research results delivery and how each of the platforms met those preferences. This included information needs as they relate to content and scope, including a desire to receive both individual and aggregate results, and study summaries. Email, paper, and website were all popular avenues of presentation. Some desired a written summary, and others preferred videos or visual graphics. Importantly, participants emphasized the desire for having a choice in the timing, frequency, and types of results.

Conclusion:

Research participants prefer to receive research results, including study impact and key findings, disseminated to them in an engaging format that allows choice of when and how the information is presented. The results encourage new standards whereby research participants are considered a critical stakeholder group.
Model-based systems engineering in modular design
Authors: Albers Albert , Bursac Nikola , Scherer Helmut , Birk Clemens , Powelske Jonas , Muschik Sabine
Published: October 2019

Modular design allows to reduce costs based on scaling effects. However, due to strong alternating effects between the resulting modules and products, methods and tools are required that enable engineers to use specific views in which the respective information can be linked and retrieved according to the situation. Within the scope of this paper, the model-based systems engineering (MBSE) approach is used to model the complex real-world problem of vehicle modular kits. The aim is to investigate the potentials in this context, how modular kits and products can be efficiently modeled and finally how MBSE can support modular design. In order to investigate this in detail, two extensive studies are carried out in a company over a period of three years. The studies show that modular kits lead to an increased complexity of development. Across industries and companies, the demand for reference product models is shown, which facilitate the unification of inhomogeneous partial models and serve as a knowledge repository for the development of future product generations. On this basis, a framework is derived which enables the reuse of large proportions of the product models of previous product generations. This framework is evaluated on the basis of five case studies.
The AristotelianTheosin Hegel'sPhilosophy of Mind
Authors: Plevrakis Ermylos
Published: October 2019

Although Hegel does not pass up the opportunity to express his deep admiration for specific aspects of the Aristotelian notion of God, he is not interested in giving a concrete account of its systematic significance for hisPhilosophy of Mindas a whole. In this article, I seek to take an overarching perspective on both the Aristotelian God and the Hegelian mind. By contrast to the common practice of focusing on Hegel's interpretation of Aristotle in hisLectures on the History of Philosophy, I first examine the Aristotelian text itself and then focus on Hegel'sEncyclopaedia Philosophy of Mind, in order to explore the coincidence between the two conceptions from a systematic point of view. With regard to Aristotle, I argue that ‘God’ represents the conceptual vanishing point of his philosophy at which all philosophical sciences appear to converge. With regard to Hegel, I show that it is precisely such conceptual convergence of all philosophical sciences that constitutes both the starting and ending points of thePhilosophy of Mind. The result is a novel meta-scientific and non-theistic conception of ‘God’ that provides the means not only to re-evaluate the systematic relation between Hegel and Aristotle but also to reconsider the character, content and aim of speculative philosophy in general.
Vegetation classification enables inferring mesoscale spatial variation in plant invasibility
Authors: Li Yue M. , Stauffer Brett , Malusa Jim
Published: October 2019

Large-scale control of invasive plants can benefit strongly from reliable assessment of spatial variation in plant invasibility. With this knowledge, limited management resources can be concentrated in areas of high invasion risk. We assessed the influence of spatial environments and proximity to roads on the invasibility of African mustard (Brassica tournefortiiGouan) over the 280,000-ha Barry M. Goldwater Range West in southwestern Arizona, USA. We used presence/absence data ofB. tournefortiiacquired from a vegetation classification project, in which lands were mapped to the level of vegetation subassociations. Logistic regression models suggested that spatial environments represented by the subassociations, not proximity to roads, represented the only factor significantly explainingB. tournefortiipresence. We then used the best model to predictB. tournefortiiinvasibility in each subassociation. This prediction indicates management strategy should differ between the western part and the central to eastern part of the range. The western range is a large spatial continuum with intermediate to high invasion risk, vulnerable to an untethered spread ofB. tournefortii. Controlling efforts should focus on preventing existing local populations from further expansion. The central and eastern ranges are a mosaic varying strongly in invasion risk. Control efforts can take advantage of natural invasion barriers and further reduce connectivity through removal of source populations connected with other high-risk locations via roads and other dispersal corridors. We suggest our approach as one effective way to combine vegetation classification and plant invasion assessment to manage complex landscapes over large ranges, especially when this approach is used through an iterative prediction–validation process to achieve adaptive management of invasive plants.
WHEN THE KING CAME DOWN TO SUMER: THE ROYAL SOJOURN OF SAR-KALI-SARRĒ AND THE COURT OF AKKAD
Authors: Kraus N. L.
Published: October 2019

At some point early on during his reign, Sar-kali-sarrē, made a journey to Sumer. The occasion was so momentous that an entire year was named in commemoration of the excursion. This paper investigates the evidence for that royal visitation, with special attention given to the administrative documents that record the king's sojourn at Girsu. The investigation also considers the rationale for the king's decision to make an expedition to Sumer and asserts that Sar-kali-sarrē may have undertaken the journey in order to begin his building works at the Ekur in Nippur. In addition, the paper identifies some of the highest officials of the Akkadian court who traveled with the king. These individuals are significant because they are usually conspicuous in administrative documents, and as such their presence can establish prosopographic synchronisms between Sargonic archives.
3Rs as part of preclinical neuropsychiatric translational crisis, and ARRIVE guidelines as part of solution
Authors: Alstrup Aage Kristian Olsen , Sonne Christian
Published: October 2019

Objective:

The ongoing translational and reproducibility crisis dominates preclinical research today as results from animal studies often disappoint when transferred to human clinical studies. This problem is especially relevant in the field of brain diseases and translational neuropsychiatry.

Methods:

Here, we discuss if the 3R concept could be part of the translational crisis.

Results:

The focus has been on the second R, which is to reduce the variation between the experimental animals, so that the number of animals per study can be reduced. However, the risk of obtaining false results has also increased. We, therefore, recommend that researchers use a broader perspective as also suggest by Russell and Burch who founded the 3Rs when considering the 3R concept, which involves the translational aspects described in detail in their 3R book from 1959.

Conclusion:

This may together with systematic reviews and well-designed and well-performed animal studies and accurate reporting of the results indeed contribute to solving the translational crisis in preclinical research.
Religiosity, Nationalism, and Anti-Jewish Politics in Palestine and Poland: Islamic and Catholic Pilgrimages during the Interwar Era
Authors: Polak-Springer Peter
Published: October 2019

This study in comparative global history sheds light on a largely ignored forum for the politics of transition from monarchical empire to nation-state in the Middle East and Central Europe—religious festivals at sacred shrines. It compares the role of key pilgrimage festivals at politically important sacred shrines: (1) the Islamic Nabi Musa (Prophet Moses) pilgrimage to the Haram esh-Sharif and Nabi Musa Tomb near the Dead Sea in Mandatory Palestine and (2) various Catholic pilgrimages to Jasna Góra in Częstochowa in interwar Poland. The author demonstrates how these events served as sacred forums for secular politics, where various political factions contested their partisan ideas of the nation, which included the elite nationalism of Grand Mufti of Jerusalem Hajj Amin al-Husseini and the Catholic-Endecja nationalism of Polish clerical leaders. Moreover, I examine the role of these pilgrimage festivals in some of the major conflicts afflicting their respective areas, such as Arab–Jewish violence and hostility in Palestine and wars for borders as well as anti-minority sentiment, especially anti-Semitism, in Poland.
‘The want of a proper Gardiner’: late Georgian Scottish botanic gardeners as intermediaries of medical and scientific knowledge
Authors: HICKMAN CLARE
Published: October 2019

Often overlooked by historians, specialist gardeners with an expert understanding of both native and exotic plant material were central to the teaching and research activities of university botanic gardens. In this article various interrelationships in the late Georgian period will be examined: between the gardener, the garden, the botanic collection, the medical school and ways of knowing. Foregrounding gardeners’ narratives will shed light on the ways in which botanic material was gathered and utilized for teaching and research purposes, particularly for medical students, as well as highlighting the importance of the garden as a repository of botanic material for the classroom. In this way, the blurred lines between art and science, skill and scholarly activity, and shared pedagogic practices between botany and anatomy will be revealed.
Adverse childhood experiences and adult mood problems: evidence from a five-decade prospective birth cohort
Authors: Selous Camilla , Kelly-Irving Michelle , Maughan Barbara , Eyre Olga , Rice Frances , Collishaw Stephan
Published: October 2019

Background

Retrospectively recalled adverse childhood experiences (ACEs) are associated with adult mood problems, but evidence from prospective population cohorts is limited. The aims of this study were to test links between prospectively ascertained ACEs and adult mood problems up to age 50, to examine the role of child mental health in accounting for observed associations, and to test gender differences in associations.

Methods

The National Child Development Study is a UK population cohort of children born in 1958. ACEs were defined using parent or teacher reports of family adversity (parental separation, child taken into care, parental neglect, family mental health service use, alcoholism and criminality) at ages 7–16. Children with no known (n = 9168), single (n = 2488) and multiple (n = 897) ACEs were identified in childhood. Adult mood problems were assessed using the Malaise inventory at ages 23, 33, 42 and 50 years. Associations were examined separately for males and females.

Results

Experiencing single or multiple ACEs was associated with increased rates of adult mood problems after adjustment for childhood psychopathology and confounders at birth [2+ v. 0 ACEs – men: age 23: odds ratio (OR) 2.36 (95% confidence interval (CI) 1.7–3.3); age 33: OR 2.40 (1.7–3.4); age 42: OR 1.85 (1.4–2.4); age 50: OR 2.63 (2.0–3.5); women: age 23: OR 2.00 (95% CI 1.5–2.6); age 33: OR 1.81 (1.3–2.5); age 42: OR 1.59 (1.2–2.1); age 50: OR 1.32 (1.0–1.7)].

Conclusions

Children exposed to ACEs are at elevated risk for adult mood problems and a priority for early prevention irrespective of the presence of psychopathology in childhood.
A Belmont Report for Animals?
Authors: FERDOWSIAN HOPE , JOHNSON L. SYD M , JOHNSON JANE , FENTON ANDREW , SHRIVER ADAM , GLUCK JOHN
Published: October 2019

Human and animal research both operate within established standards. In the United States, criticism of the human research environment and recorded abuses of human research subjects served as the impetus for the establishment of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, and the resulting Belmont Report. The Belmont Report established key ethical principles to which human research should adhere: respect for autonomy, obligations to beneficence and justice, and special protections for vulnerable individuals and populations. While current guidelines appropriately aim to protect the individual interests of human participants in research, no similar, comprehensive, and principled effort has addressed the use of (nonhuman) animals in research. Although published policies regarding animal research provide relevant regulatory guidance, the lack of a fundamental effort to explore the ethical issues and principles that should guide decisions about the potential use of animals in research has led to unclear and disparate policies. Here, we explore how the ethical principles outlined in the Belmont Report could be applied consistently to animals. We describe how concepts such as respect for autonomy and obligations to beneficence and justice could be applied to animals, as well as how animals are entitled to special protections as a result of their vulnerability.
THE MODAL LOGIC OF SET-THEORETIC POTENTIALISM AND THE POTENTIALIST MAXIMALITY PRINCIPLES
Authors: HAMKINS JOEL DAVID , LINNEBO ØYSTEIN
Published: October 2019

We analyze the precise modal commitments of several natural varieties of set-theoretic potentialism, using tools we develop for a general model-theoretic account of potentialism, building on those of Hamkins, Leibman and Löwe [14], including the use of buttons, switches, dials and ratchets. Among the potentialist conceptions we consider are: rank potentialism (true in all larger
$V_\beta $
), Grothendieck–Zermelo potentialism (true in all larger
$V_\kappa $
for inaccessible cardinals
$\kappa $
), transitive-set potentialism (true in all larger transitive sets), forcing potentialism (true in all forcing extensions), countable-transitive-model potentialism (true in all larger countable transitive models of ZFC), countable-model potentialism (true in all larger countable models of ZFC), and others. In each case, we identify lower bounds for the modal validities, which are generally either S4.2 or S4.3, and an upper bound of S5, proving in each case that these bounds are optimal. The validity of S5 in a world is a potentialist maximality principle, an interesting set-theoretic principle of its own. The results can be viewed as providing an analysis of the modal commitments of the various set-theoretic multiverse conceptions corresponding to each potentialist account.
MATHEMATICAL RIGOR AND PROOF
Authors: HAMAMI YACIN
Published: October 2019

Mathematical proof is the primary form of justification for mathematical knowledge, but in order to count as a proper justification for a piece of mathematical knowledge, a mathematical proof must be rigorous. What does it mean then for a mathematical proof to be rigorous? According to what I shall call the standard view, a mathematical proof is rigorous if and only if it can be routinely translated into a formal proof. The standard view is almost an orthodoxy among contemporary mathematicians, and is endorsed by many logicians and philosophers, but it has also been heavily criticized in the philosophy of mathematics literature. Progress on the debate between the proponents and opponents of the standard view is, however, currently blocked by a major obstacle, namely, the absence of a precise formulation of it. To remedy this deficiency, I undertake in this paper to provide a precise formulation and a thorough evaluation of the standard view of mathematical rigor. The upshot of this study is that the standard view is more robust to criticisms than it transpires from the various arguments advanced against it, but that it also requires a certain conception of how mathematical proofs are judged to be rigorous in mathematical practice, a conception that can be challenged on empirical grounds by exhibiting rigor judgments of mathematical proofs in mathematical practice conflicting with it.
DISTANCES BETWEEN FORMAL THEORIES
Authors: KHALED MOHAMED , SZÉKELY GERGELY , LEFEVER KOEN , FRIEND MICHÈLE
Published: October 2019

In the literature, there have been several methods and definitions for working out whether two theories are “equivalent” (essentially the same) or not. In this article, we do something subtler. We provide a means to measure distances (and explore connections) between formal theories. We introduce two natural notions for such distances. The first one is that of axiomatic distance, but we argue that it might be of limited interest. The more interesting and widely applicable notion is that of conceptual distance which measures the minimum number of concepts that distinguish two theories. For instance, we use conceptual distance to show that relativistic and classical kinematics are distinguished by one concept only.
Compact UWB monopole antenna with reconfigurable band-notch characteristics
Authors: Han Liping , Chen Jing , Zhang Wenmei
Published: October 2019

A compact ultra-wideband (UWB) monopole antenna with reconfigurable band-notch characteristics is demonstrated in this paper. It is comprised of a modified rectangular patch and a defected ground plane. The band-notch property in the WiMAX and WLAN bands is achieved by etching an open-ended slot on the radiating patch and an inverted U-shaped slot on the ground plane, respectively. To obtain the reconfigurable band-notch performance, two PIN diodes are inserted in the slots, and then the notch-band can be switched by changing the states of the PIN diodes. The antenna has a compact size of 0.47 λ1 × 0.27 λ1. The simulated and measured results indicate that the antenna can operate at a UWB mode, two single band-notch modes, and a dual band-notch mode. Moreover, stable radiation patterns are obtained.
Dynamics of arbuscular mycorrhizal fungi in relation to root colonization, spore density, and soil properties among different spreading stages of the exotic plant threeflower beggarweed (Desmodium triflorum) in aZoysia tenuifolialawn
Authors: Han Xiaoge , Xu Changchao , Wang Yutao , Huang Dan , Fan Qiang , Xin Guorong , Müller Christoph
Published: October 2019

Weed invasion is a prevailing problem in modestly managed lawns. Less attention has been given to the exploration of the role of arbuscular mycorrhizal fungi (AMF) under different invasion pressures from lawn weeds. We conducted a four-season investigation into aZoysia tenuifoliaWilld. ex Thiele (native turfgrass)–threeflower beggarweed [Desmodium triflorum(L.) DC.] (invasive weed) co-occurring lawn. The root mycorrhizal colonizations of the two plants, the soil AM fungal communities and the spore densities under five different coverage levels ofD. triflorumwere investigated.Desmodium triflorumshowed significantly higher root hyphal and vesicular colonizations than those ofZ. tenuifolia, while the root colonizations of both species varied significantly among seasons. The increased coverage ofD. triflorumresulted in the following effects: (1) the spore density initially correlated with mycorrhizal colonizations ofZ. tenuifoliabut gradually correlated with those ofD. triflorum. (2) Correlations among soil properties, spore densities, and mycorrhizal colonizations were more pronounced in the higher coverage levels. (3) Soil AMF community compositions and relative abundances of AMF operational taxonomic units changed markedly in response to the increased invasion pressure. The results provide strong evidence thatD. triflorumpossessed a more intense AMF infection thanZ. tenuifolia, thus giving rise to the altered host contributions to sporulation, soil AMF communities, relations of soil properties, spore densities, and root colonizations of the two plants, all of which are pivotal for the successful invasion ofD. triflorumin lawns.
Dietary intake of tryptophan tied emotion-related impulsivity in humans
Authors: Javelle Florian , Li Descartes , Zimmer Philipp , Johnson Sheri L.
Published: October 2019

Abstract. Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system. Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. Objective: The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Methods: Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Results: Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r =  –.502, p < . 010, and (lack-of) Follow-Through scores, r =  –.407, p < . 050. Conclusion: Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits. It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.
Math Homework Purpose Scale
Authors: Sun Meilu , Du Jianxia , Xu Jianzhong
Published: October 2019

Abstract. The present study evaluated the psychometric properties of the Math Homework Purpose Scale (MHPS). After randomly splitting the sample ( N = 854) into two subsamples ( n = 427 and n = 427), we carried out exploratory factor analysis (EFA) on subsample 1 and confirmatory factor analysis (CFA) on subsample 2. The Kaiser-Meyer Olkin value of .88 indicated that EFA was appropriate for subsample 1. EFA results showed that a three-factor solution explained 72.2% of the variance. All ten of the MHPS items loaded quite substantially on three factors labeled Academic, Self-Regulatory, and Approval-Seeking. CFA results further showed that the MHPS was composed of three factors: Academic, Self-Regulatory, and Approval-Seeking. From this adequate level of measurement invariance, we further examined the latent mean difference across gender for the entire sample. Our findings showed no statistically significant mean differences in Academic, Self-Regulatory, and Approval-Seeking across gender. In addition, the HMPS was found to have adequate alpha reliability coefficients and omega coefficients. Concerning the validity evidence of the MHPS, Academic, Self-Regulatory, and Approval-Seeking purposes were positively correlated with homework effort, homework completion, and math achievement. The present study provides solid evidence that the MHPS is a reliable and valid measurement of math homework purposes.