bluuebunny/crossref_metadata_2025 huggingface dataset:
Accelerated Electrons Transfer and Synergistic Interplay of Co and Ge Atoms (111 Crystal Plane) Activated by Anchoring Nano Spinel Structure Co2GeO4 onto Carbon Cloth Composite Electrocatalyst for Highly Enhanced Hydrogen Evolution Reaction
Authors: Chen Chen , Zhu Jiarui , Cheng Ting , Wu Fei , Xie Jun , He Dawei , Dai Youzhi , Zhang Xiao , Zhao Le , Wei Zhongsheng
Published: September 2024

The electrochemical hydrogen evolution reaction (HER) was considered to be a promising strategy for future clean energy. In this work, a composite electrocatalyst (designated as CGO36@CC) was synthesized through anchoring of nano spinel structure Co2GeO4 onto carbon cloth fibers and exhibited outstanding electrocatalytic performance for HERs in an alkaline medium. The characterization outcome established that, after 36 h of hydrothermal reaction, nano spinel structure Co2GeO4 particles (exposed abundant 111 crystal planes) were stably loaded onto a carbon cloth fiber surface, and this structural configuration facilitated the electrons transferring between each other. In addition, the electrochemical analysis revealed that the incorporation of nano spinel structure Co2GeO4 and carbon cloth significantly augmented the electrochemical activity value of the composite and efficiently enhanced the HER performance. Notably, the overpotential was merely 96 mV at 10 mA·cm−2 current density, and the Tafel slope was only 48.9 mV·dec−1. Moreover, CGO36@CC displayed remarkable catalytic activity and sustained HER catalytic stability. The theoretical catalytic prowess of CGO36@CC stemmed from the collaborative influence of germanium and cobalt atoms within the exposed 111 crystal plane of the Co2GeO4 molecular framework. The amalgamation of Co2GeO4 with carbon cloth fiber conferred upon the composite electrocatalyst both superior theoretical catalytic activity and enhanced electron transfer capability. This work provides a novel strategy for exploring a highly efficient composite electrocatalyst combined transition metal with carbon material to accelerate the HER activity.
Innovative Strategies for Liver Transplantation: The Role of Mesenchymal Stem Cells and Their Cell-Free Derivatives
Authors: Akabane Miho , Imaoka Yuki , Kawashima Jun , Endo Yutaka , Schenk Austin , Sasaki Kazunari , Pawlik Timothy M.
Published: September 2024

Despite being the standard treatment for end-stage liver disease, liver transplantation has limitations like donor scarcity, high surgical costs, and immune rejection risks. Mesenchymal stem cells (MSCs) and their derivatives offer potential for liver regeneration and transplantation. MSCs, known for their multipotency, low immunogenicity, and ease of obtainability, can differentiate into hepatocyte-like cells and secrete bioactive factors that promote liver repair and reduce immune rejection. However, the clinical application of MSCs is limited by risks such as aberrant differentiation and low engraftment rates. As a safer alternative, MSC-derived secretomes and extracellular vesicles (EVs) offer promising therapeutic benefits, including enhanced graft survival, immunomodulation, and reduced ischemia–reperfusion injury. Current research highlights the efficacy of MSC-derived therapies in improving liver transplant outcomes, but further studies are necessary to standardize clinical applications. This review highlights the potential of MSCs and EVs to address key challenges in liver transplantation, paving the way for innovative therapeutic strategies.
Effects of an 8-Week Active Play Intervention on Body Composition and Fundamental Motor Skills in Preschool Children
Authors: Spring Katherine E. , Lang Danielle , Pangelinan Melissa M. , Wadsworth Danielle D.
Published: September 2024

Objective: Examine the effect of an 8-week teacher-guided active play intervention on preschoolers’ body composition and fundamental motor skills. Methods: Participants were from two local preschool centers randomly assigned to either the intervention (n = 25, 3.91 ± 0.53 years) or the control group (n = 25, 3.69 ± 0.81 years). All measures were assessed at baseline (week 0), post-intervention (weeks 9–11), and follow-up (weeks 30–33). Bioelectrical Impedance assessed body composition (fat mass (FM) and fat-free mass (FFM)). The Peabody Developmental Motor Scales, Second Edition (PDMS-2) assessed fundamental motor skills (gross motor quartile (GMQ)). Results: A significant Group × Time interaction for GMQ at post-intervention (p = 0.03), with the intervention group scoring significantly higher on GMQ. A significant main effect of Time (p < 0.001) indicated that GMQ increased in both groups across the 33-week period. For FM, a significant main effect of Time at both post-intervention (p < 0.05) and follow-up testing (p < 0.001) indicated that participants increased FM over the 33-week period. Lastly, there was a significant main effect of Time for FFM at post-intervention (p = 0.003) and follow-up (p < 0.001). Interestingly, there was a significant Group × Time interaction (p < 0.05) at follow-up testing showing that FFM increased over time but significantly more for the control group. Conclusions: Results indicate that active play interventions might be a successful pathway to improve gross motor skills in young children. Further research is needed to understand the effect that active play interventions have on body composition in preschoolers.
The Microbiota in Children and Adolescents with Asthma
Authors: Casali Lucio , Stella Giulia Maria
Published: September 2024

The role of the respiratory microbiome has been deeply explored for at least two decades. Its characterization using modern methods is now well-defined, and the impacts of many microorganisms on health and diseases have been elucidated. Moreover, the acquired knowledge in related fields enables patient stratification based on their risk for disease onset, and the microbiome can play a role in defining possible phenotypes. The interplay between the lung and gut microbiomes is crucial in determining the microbial composition and immuno-inflammatory reaction. Asthma is still not a well-defined condition, where hyperreactivity and the immune system play important roles. In this disease, the microbiome is mostly represented by Proteobacteria, Streptococcus, and Veillonella, while Cytomegalovirus and Epstein–Barr viruses are the most prevalent viruses. A mycobiome may also be present. The passage from infancy to adolescence is examined by evaluating both the clinical picture and its relationship with possible variations of the microbiome and its effects on asthma. Otherwise, asthma is considered a heterogeneous disease that often starts in childhood and follows a particular personalized track, where adolescence plays a pivotal role in future prognosis. Under this point of view, the microbiota, with its possible variations due to many factors, both internal and external, can modify its composition; consequently, its inflammatory action and role in the immunological response has obvious consequences on the clinical conditions.
Free-Weight Resistance Training Enhances Core Muscle Strength but Does Not Translate to Improved Athletic Performance in Adolescent Canoe/Kayak Athletes
Authors: Lee Ting-Ting , Ko Bo-Jen , Chang Chu-Han , Cheng I-Shiung
Published: September 2024

Background/Objectives: While previous evidence has shown that using free weights for resistance training is a more practical approach to enhancing strength, there is a relatively low prevalence of free-weight resistance training among adolescent kayak/canoe athletes. Therefore, this study aims to assess the impact of free-weight resistance training on body composition and various performance factors among adolescent canoe/kayak athletes. Methods: Twenty-seven young sprint kayakers and canoeists (14 ± 1 years; 164 ± 7 cm; 56 ± 8 kg) completed this study. Following baseline assessments, athletes were randomly divided into two training groups: the free-weight resistance training group (FW) or the control group (C). The FW group underwent free-weight resistance training sessions twice weekly for 24 weeks. The C group maintained their regular bodyweight training sessions during the same timeframe. All participants performed both the pre- and post-training assessments for the following dependent variables: body composition, upper-body power, upper-body isometric muscle strength, isometric mid-thigh pull, core strength, countermovement jump, balance, anaerobic ability, and aerobic performance. Results: After 24 weeks of training, the free-weight resistance training group exhibited a significant increase in body weight (from 56 ± 5 kg to 58 ± 4 kg, p < 0.05) and improvements in the number of straight leg raise repetitions (from 23 ± 6 to 26 ± 4, p < 0.05) compared to the control group. However, the two groups observed no significant differences between upper-body isometric muscle strength, power, balance, and anaerobic/aerobic performance. Conclusions: A 24-week training duration might be insufficient for novice participants in resistance training. Future research should consider incorporating an adaptation period or a learning phase for movements before training, thereby enhancing the efficacy of free-weight resistance training in increasing strength.
Automated Measurements of Long Leg Radiographs in Pediatric Patients: A Pilot Study to Evaluate an Artificial Intelligence-Based Algorithm
Authors: van der Lelij Thies J. N. , Grootjans Willem , Braamhaar Kevin J. , de Witte Pieter Bas
Published: September 2024

Background: Assessment of long leg radiographs (LLRs) in pediatric orthopedic patients is an important but time-consuming routine task for clinicians. The goal of this study was to evaluate the performance of artificial intelligence (AI)-based leg angle measurement assistant software (LAMA) in measuring LLRs in pediatric patients, compared to traditional manual measurements. Methods: Eligible patients, aged 11 to 18 years old, referred for LLR between January and March 2022 were included. The study comprised 29 patients (58 legs, 377 measurements). The femur length, tibia length, full leg length (FLL), leg length discrepancy (LLD), hip–knee–ankle angle (HKA), mechanical lateral distal femoral angle (mLDFA), and mechanical medial proximal tibial angle (mMPTA) were measured automatically using LAMA and compared to manual measurements of a senior pediatric orthopedic surgeon and an advanced practitioner in radiography. Results: Correct landmark placement with AI was achieved in 76% of the cases for LLD measurements, 88% for FLL and femur length, 91% for mLDFA, 97% for HKA, 98% for mMPTA, and 100% for tibia length. Intraclass correlation coefficients (ICCs) indicated moderate to excellent agreement between AI and manual measurements, ranging from 0.73 (95% confidence interval (CI): 0.54 to 0.84) to 1.00 (95%CI: 1.00 to 1.00). Conclusion: In cases of correct landmark placement, AI-based algorithm measurements on LLRs of pediatric patients showed high agreement with manual measurements.
Effect of ZrO2 Particles on the Microstructure and Ultrasonic Cavitation Properties of CoCrFeMnNi High-Entropy Alloy Composite Coatings
Authors: Yin Danqing , Chang Junming , Wang Yonglei , Ma Ning , Zhao Junnan , Zhao Haoqi , Wang Meng
Published: September 2024

CoCrFeMnNi-XZrO2 (X is a mass percentage, X = 1, 3, 5, and 10) high-entropy alloy composite coatings were successfully prepared on 0Cr13Ni5Mo martensitic stainless steel substrates using laser cladding technology. The phase composition, microstructure, mechanical properties, and cavitation erosion behavior of the composite coatings under different contents of ZrO2 were studied. The mechanism of ZrO2 particle-reinforced cavitation corrosion resistance was studied using ABAQUS2023 finite element software. The results show that the phase structure of the composite coating organization is composed of FCC phase reinforced by ZrO2 phase. The addition of ZrO2 causes lattice distortion. The coatings have typical branch crystals and an equiaxed crystal microstructure. With the increase in ZrO2 content, the microhardness of the composite coatings gradually increases. When X = 10%, the coating’s microhardness reached 348 HV, which was 95.53% higher than the high-entropy alloys without ZrO2 added. Adding ZrO2 can prolong the incubation period of high-entropy alloys; the high-entropy alloy composite coating with 5 wt.% ZrO2 exhibited the best cavitation resistance, with a cumulative volume loss rate of only 15.74% of the substrate after 10 h of ultrasonic cavitation erosion. The simulation results indicate that ZrO2 can withstand higher stress and deformation in cavitation erosion, reduce the degree of substrate damage, and generate higher compressive stress on the coating surface to cope with cavitation erosion.
Collision Dynamics of One-Dimensional Bose–Einstein Condensates
Authors: Wirthwein Aaron , Haas Stephan , Chiow Sheng-wey
Published: September 2024

We study the collision dynamics of two Bose–Einstein condensates, with their dynamical wave functions modeled by a set of coupled, time-dependent Gross–Pitaevskii equations. In an effective one-dimensional system, we identify regimes characterized by the relationship between inter- and intra-atomic interactions and the initial configuration of the system, akin to the equilibrium phase diagram of two interacting Bose condensates. We consider a dynamical setup in which two wave packets are initially at rest, with a small separation about the center of an anisotropic harmonic trap. Upon release, we observe a rapid approach to dynamical equilibrium in the limits of very large and very small inter-particle repulsion, characterized by periodic transmission or reflection of the condensates as distinguishable units, whereas the intermediate, critical regime is characterized by extended transient dynamics, density fracturing, and dynamical mixing.
Density Functional Theory Study of Lanthanide Monoxides under High Pressure: Pressure-Induced B1–B2 Transition
Authors: Ferrari Sergio , Errandonea Daniel
Published: September 2024

Using density functional theory, we study the influence of hydrostatic pressure on the crystal structure of lanthanide monoxides, focusing on the monoxides formed by the fifteen elements of the lanthanide series, from La to Lu. Calculations are performed using two methods for the ambient pressure B1 (NaCl type) structure, the general gradient approximation (GGA) and the local density approximation (LDA). Through a systematic comparison with existent experimental data, we find that the first method agrees better with the experiments. In addition, considering other cubic structures previously reported for lanthanide monoxides, as B2 (CsCl type) and B3 (ZnS type), we explore the possibility of the occurrence of pressure-induced phase transitions. Based on the better accuracy of GGA to describe the B1 phase at ambient conditions, we exclusively use GGA for the high pressure study. We find, for the fifteen studied compounds, that, at ambient pressure, the B1 structure is the one with the lowest enthalpy, being therefore the most thermodynamically stable structure. We also determine that, at elevated pressures, all the studied compounds undergo a structural phase transition to the B2 phase. We finally establish the relationship between pressure and volume of the unit cell, along with the associated isothermal equation of state, determining the bulk modulus.
Influences of La2O3 Addition on Connectivity of Phase Compositions and Microstructural Evolution of Weld Slag
Authors: He Xiaoyu , Zhang Min , Lei Longyu , Li Yi
Published: September 2024

In this work, the influences of La2O3 addition on the connectivity of the glass network, phase compositions and microstructural evolution of weld slag were investigated through Raman spectrum, X-ray powder diffraction (XRPD), SEM and EBSD technologies. All experimental results indicated that La2O3 addition could modify the whole glass network’s connectivity and short-ordered units. According to the Raman spectrum, only 1 wt.% La2O3 addition resulted in the occurrence of a unique linking mode of Si-O and Al-O tetrahedrons that was assigned to feldspar phases (albite or anorthite). Further XRPD examination showed that the primary phases were albite and anorthite, which agreed with the Raman results. Moreover, enhanced linkage between Si-O and Al-O tetrahedrons needs a large amount Na+ to achieve electric neutrality. This repaired the connectivity of the slag network due to the lack of Na+. Additionally, the solubility of La2O3 in the slag matrix was limited to about 3 wt.%. Adding further La2O3 to this weld slag, the existence form of La2O3 retained its original status. Thus, La2O3 addition that exceeded 3 wt.% had little effect on the slag connectivity besides providing a phase interface. In conclusion, La2O3 addition in weld slag could promote the hardness and the formation of feldspar phases. Feldspar is an extremely fragile silicon aluminate crystal. The factors mentioned above caused the detachability to be enhanced when adding La2O3.
Real-World Treatment Patterns, Sequencing, and Outcomes in Patients with Locally Advanced or Metastatic Urothelial Carcinoma Receiving Avelumab First-Line Maintenance in the United States
Authors: Moon Helen H. , Kearney Mairead , Mahmoudpour Seyed Hamidreza , Ike Chiemeka , Morris Valerie , Rava Andrew , Kim Sonia , Sun Haiyan , Boyd Marley , Gomez Rey Gabriel
Published: September 2024

For patients with locally advanced/metastatic urothelial carcinoma (la/mUC), first-line (1L) treatment with platinum-based chemotherapy (PBC) followed by avelumab 1L maintenance (1LM) is a recommended therapy per treatment guidelines in patients without disease progression. However, contemporary real-world (rw) data among patients receiving this treatment are necessary to understand clinical outcomes and optimal treatment sequencing. This retrospective cohort study analyzed rw treatment patterns and clinical outcomes, including overall survival (rwOS) and progression-free survival (rwPFS), in patients with la/mUC receiving avelumab 1LM. From the Flatiron Health database, 214 patients who received avelumab 1LM following 1L PBC were included. From the start of avelumab 1LM, median rwOS was 23.8 months (95% CI: 18.2—not estimable [NE]) and median rwPFS was 5.1 months (95% CI: 4.1–7.0). A total of 96 patients received second-line (2L) therapy, with 53 receiving enfortumab vedotin (EV). From the start of 2L EV, median rwOS was 11.2 months (95% CI: 6.8—NE) and median rwPFS was 4.9 months (95% CI: 3.9–8.8). Treatment patterns and clinical outcomes in this study align with guidelines and outcomes observed in the JAVELIN Bladder 100 and EV-301 clinical trials and other rw studies, supporting the use of 1L PBC followed by avelumab 1LM and 2L EV for eligible patients.
Chemotherapy-Induced Alopecia by Docetaxel: Prevalence, Treatment and Prevention
Authors: Perez Aleymi M. , Haberland Nicole I. , Miteva Mariya , Wikramanayake Tongyu C.
Published: September 2024

Docetaxel is a commonly used taxane chemotherapeutic agent in the treatment of a variety of cancers, including breast cancer, ovarian cancer, prostate cancer, non-small cell lung cancer, gastric cancer, and head and neck cancer. Docetaxel exerts its anti-cancer effects through inhibition of the cell cycle and induction of proapoptotic activity. However, docetaxel also impacts rapidly proliferating normal cells in the scalp hair follicles (HFs), rendering the HFs vulnerable to docetaxel-induced cell death and leading to chemotherapy-induced alopecia (CIA). In severe cases, docetaxel causes persistent or permanent CIA (pCIA) when hair does not grow back completely six months after chemotherapy cessation. Hair loss has severe negative impacts on patients’ quality of life and may even compromise their compliance with treatment. This review discusses the notable prevalence of docetaxel-induced CIA and pCIA, as well as their prevention and management. At this moment, scalp cooling is the standard of care to prevent CIA. Treatment options to promote hair regrowth include but are not limited to minoxidil, photobiomodulation (PBMT), and platelet-rich plasma (PRP). In addition, a handful of current clinical trials are exploring additional agents to treat or prevent CIA. Research models of CIA, particularly ex vivo human scalp HF organ culture and in vivo mouse models with human scalp xenografts, will help expedite the translation of bench findings of CIA prevention and/or amelioration to the clinic.
A New Species of Cyprinid Genus Opsariichthys (Teleostei: Cyprinidae) from the Pearl River, Southern China †
Authors: Chen Jia-Bo , Li Ying-Tao , Zhou Jia-Jun , Li Cheng , Weng Guo-Xi , Lin Hung-Du , Wang Jun-Jie
Published: September 2024

A new cyprinid fish, Opsariichthys rubriventris sp. nov., is described from the Xizhijiang River, a tributary of the Pearl River basin in Huizhou City, Guangdong Province, southern China. The species is distinguished from all other congeners by the following combination of characters: predorsal scales 13–14; lower jaw projecting slightly beyond upper jaw; cheek with two mainly longitudinal rows of tubercles; and lower jaw, belly, pectoral fin, and anterior margin of anal fin in adult males being reddish-orange. The principal component analysis result of the morphological data indicated that O. rubriventris sp. nov. could be clearly distinguished fromfour other congeners. The phylogenetic analysis conducted in this study, utilizing both Maximum Likelihood (ML) and Bayesian Inference (BI) methods, supported the monophyly of the novel species O. rubriventris sp. nov. at the species level. Additionally, the genetic distance analysis revealed that O. rubriventris sp. nov. exhibits a genetic distance ranging from 0.14 to 0.16 with its congeneric species, further affirming its taxonomic status.
Comparison of Clinical Characteristics between Responders and Non-Responders to Hamstring Stretching in Individuals with Chronic Low Back Pain
Authors: Dobija Lech , Pereira Bruno , Dupeyron Arnaud , Coudeyre Emmanuel
Published: September 2024

Background/Objectives: Hamstring muscle (HM) flexibility is frequently compromised in people with chronic low back pain (CLBP), contributing to disability and leading to a less favorable recovery. In a previous article, we presented the results of a study on the immediate effect of passive HM stretching on flexibility in 90 people with CLBP. There was considerable variability in the changes after stretching. The objective of this supplementary analysis was to compare the clinical characteristics of individuals who experienced a significant improvement in flexibility with those who did not. Methods: We fixed a threshold of 7° to indicate an improvement in passive Straight Leg Raise (SLR) angle and differentiate between ‘Responders’ and ‘Non-responders’ regarding passive HM stretching. Results: Only body mass index differed between groups; it was significantly smaller in Responders (p = 0.007). The majority of Non-responders experienced workplace accidents, but this was of marginal difference compared to Responders (p = 0.056). Conclusions: Further studies should consider a broader clinical analysis with a larger sample size to understand which factors influence the HM stretching response in CLBP patients.
COVID-19 and Female Fertility: An Observational Prospective Multicenter Cohort Study: Upholding Reproductive Rights in Emergency Circumstances
Authors: Gullo Giuseppe , Lopez Alessandra , Loreto Carla , Cucinella Gaspare , La Verde Marco , Andrisani Alessandra , Burgio Sofia , Carotenuto Raffaela , Ganduscio Silvia , Baglio Giovanni , Billone Valentina , Perino Antonio , De Franciscis Pasquale , Marinelli Susanna
Published: September 2024

Objectives: Currently available research data points to COVID-19-related multi-organ system damage. This study aims to evaluate the impact of SARS-CoV-2 on the reproductive health, that is, plasma levels of FSH, LH, estradiol, AMH, and antral follicular count, of women undergoing level II ART techniques. Methods: This is a multicenter, prospective, and observational study by the reproductive medicine centers of Palermo’s Ospedali Riuniti Villa Sofia-Cervello Hospital and Vanvitelli University. From September 2022 to March 2024, 203 patients aged 24–43 were enrolled, all with diagnosed infertility and a history of SARS-CoV-2 infection. Symptomatic women, patients testing positive for HIV or other liver viruses, and patients with a history of ovarian cancer or who had taken gonadotoxic drugs were excluded. Plasma measurements of FSH, LH, estradiol, AMH, and antral follicular count were performed before and after infection. Results: The analysis accounting for the concentration of anti-Müllerian hormone (AMH) before and after COVID-19 infection shows an average concentration decrease from 1.33 ng/mL before SARS-CoV-2 infection to 0.97 ng/mL after infection. Average decrease after infection was −27.4%; average reduction of 1 follicle (95% CI: from −0.74 to −1.33) was reported following SARS-CoV-2 infection. Levels of E2 before and after SARS-CoV-2 infection did not vary significantly. Average FSH and LH levels before and after SARS-CoV-2 infection pointed to an increase. Conclusions: SARS-CoV-2 infection damages female reproductive health, causing significant reductions in AMH (−27.4%) and AFC (−1 antral follicle) values and an increase in FSH (+13.6%) and LH (+13.4%) values. No effect on E2 levels was reported. The pandemic has also affected the ability of infertile patients to access ART procedures, and that calls for a novel, updated blueprint designed to enhance our preparedness in the event that similar circumstances should occur again.
A Pilot Study of the Computerized Brief Smell Identification Test
Authors: Jiang Rong-San , Chiang Yi-Fang
Published: September 2024

Objectives: A self-administered Computerized Brief Smell Identification Test (cB-SIT) was developed recently to perform the olfactory identification test under computer control. The aim of this study was to evaluate the clinical applicability of the cB-SIT as compared with the traditional Brief Smell Identification Test (B-SIT). Methods: Sixty healthy volunteers with self-reported normal olfactory function, 30 hyposmic patients, and 30 anosmic patients were enrolled from June 2023 to May 2024. All enrolled participants received both B-SIT and cB-SIT in a random order to measure their odor identification ability. Thirty healthy volunteers took the second B-SIT and cB-SIT at least one week later. Results: The score was significantly different in both B-SIT and cB-SIT among healthy volunteers, hyposmic, and anosmic patients. The correct answer rate was significantly different in 10 items of the B-SIT and in 7 items of the cB-SIT among the three groups, but the post hoc test showed significant differences in correct answer rates between healthy volunteers and hyposmic patients in 7 items of both the B-SIT and cB-SIT. Test–retest results showed the score of the second B-SIT test was significantly higher than that of the first test, but the scores of the two tests of the cB-SIT were not significantly different. In the B-SIT, the lemon odorant had a higher correct answer rate in the second test than in the first test, but in the cB-SIT, the correct answer rate was not significantly different between the first and second tests in all 12 items. Conclusions: Our findings demonstrate that the cB-SIT was similar to the B-SIT and can be administered in the diagnosis of patients with olfactory dysfunction.
The Efficacy of Diagnostic Plaster Models in Orthodontic Diagnosis and Treatment Planning
Authors: Almudhi Abdullazez , Almohammad Iman , Alswayyed Sara , Eldwakhly Elzahraa , Almugairin Sarah
Published: September 2024

Background: The growing integration of digital technologies in orthodontics is shifting the orthodontic diagnosis and recordkeeping paradigm, replacing conventional plaster models with intraoral scanning and 3D photography. This study investigated the impact of orthodontic plaster models on orthodontic diagnosis and treatment planning decisions by orthodontists. Methods: Thirty-three orthodontists assessed six patients’ records with different malocclusion cases. Each case was assessed twice by each orthodontist evaluating a case: the first evaluation with digital records without diagnostic casts and the second evaluation with the added diagnostic orthodontic plaster model. Diagnostic and treatment plan decisions for each malocclusion case were compared with and without the aid of the diagnostic orthodontic plaster models to assess the plaster model’s impact on the treatment plan’s soundness. Results: Statistically insignificant differences were found for the diagnoses and treatment plans with or without the aid of orthodontic plaster models. Intraclass correlation coefficients revealed agreement among orthodontists for both evaluated situations (0.685; p < 0.0001). Plaster models were found to significantly influence orthodontists’ decisions about the need for surgical intervention (p = 0.026), but they did not significantly impact the overall malocclusion diagnostic classification nor the decision regarding the extent of treatment, whether comprehensive or limited (p = 0.146) and extraction versus non-extraction approaches (p = 0.266). Conclusions: These findings support the idea that digital record alternatives may be viable for orthodontic recordkeeping purposes. Within the limitations of this study, it can be concluded that the presence or absence of orthodontic plaster models does not significantly impact the orthodontic diagnosis or treatment planning process.
Evaluation of Diagnostic Performance of Three Commercial Interferon-Gamma Release Assays for Mycobacterium tuberculosis
Authors: Kutame Richard , Boateng Gifty , Adusi-Poku Yaw , Sorvor Felix , Antwi Lorreta , Agyemang-Bioh Florence , Ayensu Bright , Gyau-Boateng Vincent , Asiedu-Bekoe Franklin
Published: September 2024

Interferon-gamma release assays (IGRAs) have gained attention for the diagnosis of latent tuberculosis infection (LTBI) due to their higher specificity compared to the tuberculin skin test (TST). However, the IGRA’s performance varies across different populations. This study evaluated the diagnostic performance of three IGRAs (TBF-FIA, TBF-ELISA, and QFT-Plus) in Ghana, comparing them among individuals exposed and unexposed to MTB infection. Conducted in TB clinics across three regions, this prospective and cross-sectional study included healthy individuals with no known TB exposure (unexposed group) and patients with confirmed active TB (exposed group). Blood samples were tested using all three assays as per the manufacturers’ guidelines. The TBF-ELISA showed 3.4% higher sensitivity but 4.6% lower specificity compared to QFT-Plus. The TBF-FIA had sensitivity of 78.5–87.3% and specificity of 82.9–90.0%. These findings indicate that while the three IGRAs offer similar diagnostic accuracy, the variations in specificity and limited data on assays like TBF-FIA require further investigation.
Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography
Authors: Plekhanov Anton A. , Grechkanev Gennady O. , Avetisyan Elena A. , Loginova Maria M. , Kiseleva Elena B. , Shepeleva Anastasia A. , Moiseev Alexander A. , Sovetsky Alexander A. , Gubarkova Ekaterina V. , Anina Anastasia A. , Shutova Angelina M. , Gamayunov Sergey V. , Gelikonov Grigory V. , Zaitsev Vladimir Y. , Sirotkina Marina A. , Gladkova Natalia D.
Published: September 2024

Objectives: The most important phase in the endometrial pathologies diagnostics is the histological examination of tissue biopsies obtained under visual hysteroscopic control. However, the unclear visual diagnostics characteristics of subtle focal endometrial pathologies often lead to selection errors regarding suspicious endometrial lesions and to a subsequent false pathological diagnosis/underestimation of precancer or early-stage cancer. Methods: In this study, we investigate the potential of Multimodal Optical Coherence Tomography (MM OCT) to verify suspicious endometrial lesion regions before biopsy collection. We study the polarization (by cross-polarization OCT, CP OCT) and elastic (by compression OCT-elastography, C-OCE) properties of ex vivo endometrial tissue samples in normal conditions (proliferative and secretory phases to the menstrual cycle, atrophic endometrium) with endometrial hyperplasia (non-atypical and endometrial intraepithelial neoplasia) and endometrial cancer subtypes (low-grade, high-grade, clear cell and serous). Results: To the best of our knowledge, this is the first quantitative assessment of relevant OCT parameters (depth-resolved attenuation coefficient in co-[Att(co) values] and cross-[(Att(cross) values] polarizations and Young’s elastic modulus [stiffness values]) for the selection of the most objective criteria to identify the clinically significant endometrial pathologies: endometrial intraepithelial neoplasia and endometrial cancer. The study demonstrates the possibility of detecting endometrial pathologies and establishing optimal threshold values of MM OCT criteria for the identification of endometrial cancer using CP OCT (by Att(co) values = 3.69 mm−1, Sensitivity (Se) = 86.1%, Specificity (Sp) = 92.6%; by Att(cross) values = 2.27 mm−1, Se = 86.8%, Sp = 87.0%) and C-OCE (by stiffness values = 122 kPa, Se = 93.2%, Sp = 91.1%). The study also differentiates endometrial intraepithelial neoplasia from non-atypical endometrial hyperplasia and normal endometrium using C-OCE (by stiffness values = 95 kPa, Se = 87.2%, Sp = 90.1%). Conclusions: The results are indicative of the efficacy and potential of clinical implementation of in vivo hysteroscopic-like MM OCT in the diagnosis of endometrial pathologies.
Comparative Assessment of Pharyngeal Airway Dimensions in Skeletal Class I, II, and III Emirati Subjects: A Cone Beam Computed Tomography Study
Authors: AlAskar Sara , Jamal Mohamed , Khamis Amar Hassan , Ghoneima Ahmed
Published: September 2024

The aim of the current study was to evaluate the pharyngeal airway dimensions of individuals with different skeletal patterns in a cohort of the Emirati population. The specific aim was to assess the relationship between pharyngeal airway dimensions and anterior facial height in relation to different skeletal patterns. This retrospective study was conducted on a sample of 103 CBCT scans of adult Emirati subjects categorized into three groups according to their skeletal classification as indicated by the ANB angle: Class I (n = 35), Class II (n = 46), and Class III (n = 22). All CBCT scans were taken using an i-CAT CBCT imaging machine (Imaging Sciences, Hatfield, PA, USA). The age range of the patients was 19 to 68 years (62 women and 41 men). ANOVA, t-tests, Kruskal–Wallis, and Mann–Whitney tests were employed for comparing means among groups. The correlation coefficient was used to evaluate the association between variables. A p-value of less than 0.05 was considered statistically significant. This study revealed significant associations between various airway parameters and cephalometric measurements. Positive correlations were observed between nasal cavity volume and nasopharynx volume, as well as anterior facial height. Oropharynx volume exhibited positive correlations with hypopharynx volume and total airway volume, and negative correlations with overjet, ANB angle, and patient age. Hypopharynx volume correlated positively with total airway volume and the most constricted area of the airway (MCA). Total airway volume showed positive correlations with MCA and anterior facial height. MCA had negative correlations with ANB angle and patient age. Nasopharynx volume was significantly larger in the skeletal Class I group than in the Class II or Class III groups, while the other airway parameters showed no significant differences among the groups (p > 0.05). Several airway parameters showed a correlation with anterior facial height among the different skeletal patterns. Nasopharyngeal airway volume was significantly larger in the skeletal Class I group than in Class II and III groups in the studied sample.
Enhancing Unmanned Aerial Vehicle Path Planning in Multi-Agent Reinforcement Learning through Adaptive Dimensionality Reduction
Authors: Shi Haotian , Zhao Zilin , Chen Jiale , Zhou Mengjie , Liu Yang
Published: September 2024

Unmanned Aerial Vehicles (UAVs) have become increasingly important in various applications, including environmental monitoring, disaster response, and surveillance, due to their flexibility, efficiency, and ability to access hard-to-reach areas. Effective path planning for multiple UAVs exploring a target area is crucial for maximizing coverage and operational efficiency. This study presents a novel approach to optimizing collaborative navigation for UAVs using multi-agent reinforcement learning (MARL). To enhance the efficiency of this process, we introduce the Adaptive Dimensionality Reduction (ADR) framework, which includes Autoencoders (AEs) and Principal Component Analysis (PCA) for dimensionality reduction and feature extraction. The ADR framework significantly reduces computational complexity by simplifying high-dimensional state spaces while preserving crucial information. Additionally, we incorporate communication modules to facilitate inter-UAV coordination, further improving path planning efficiency. Our experimental results demonstrate that the proposed approach significantly enhances exploration performance and reduces computational complexity, showcasing the potential of combining MARL with ADR techniques for advanced UAV navigation in complex environments.
Simulating Weak Attacks in a New Duplication–Divergence Model with Node Loss
Authors: Zhang Ruihua , Reinert Gesine
Published: September 2024

A better understanding of protein–protein interaction (PPI) networks representing physical interactions between proteins could be beneficial for evolutionary insights as well as for practical applications such as drug development. As a statistical model for PPI networks, duplication–divergence models have been proposed, but they suffer from resulting in either very sparse networks in which most of the proteins are isolated, or in networks which are much denser than what is usually observed, having almost no isolated proteins. Moreover, in real networks, where a gene codes a protein, gene loss may occur. The loss of nodes has not been captured in duplication–divergence models to date. Here, we introduce a new duplication–divergence model which includes node loss. This mechanism results in networks in which the proportion of isolated proteins can take on values which are strictly between 0 and 1. To understand this new model, we apply strong and weak attacks to networks from duplication–divergence models with and without node loss, and compare the results to those obtained when carrying out similar attacks on two real PPI networks of E. coli and of S. cerevisiae. We find that the new model more closely reflects the damage caused by strong and weak attacks found in the PPI networks.
Design, Simulation and Performance of a CSI Converter for Grid-Connected or Islanded Microgrids with High Step-Up Capability in PV Applications
Authors: Di Stefano Roberto , Marignetti Fabrizio , Pellini Fabio
Published: September 2024

In the context of energy conversion from renewable sources to distribution grids (insulated or not), a converter is often required to transfer energy from a low voltage source towards three-phase grids. This paper presents the HW design, the simulation results, and the conversion performance of a CSI converter intended to interface low-voltage renewable sources to three-phase grids. The main focus of this paper is to obtain the best performance in terms of voltage increase towards the output stage while maximizing the conversion efficiency. In comparison with the currently used energy conversion systems for small photovoltaic systems, hereafter some solutions were adopted to level and maximize the energy flow from the source to the DC-link and improve the quality of current supplied in terms of harmonic distortion. The proposed system is composed of two conversion stages: the first, voltage-to-current, the second current-to-current via a three-phase CSI bridge modulated with the SVM technique. The stages are not completely decoupled from an electrical point of view; therefore, in order to mitigate the effects of these interactions, synchronization strategies have been adopted.
Manufacturing Strategies for a Family of Integrated Photovoltaic-Fuel Cell Systems
Authors: Ogbonnaya Chukwuma , Hegarty Grace
Published: September 2024

Integrated photovoltaic-fuel cell (IPVFC) systems have the potential to contribute to sustainable energy production for grid and off-grid applications. While there are studies focusing on fundamental science and designs for IPVFC systems, there are few studies that have focused on the manufacturability of IPVFC systems, which is certainly the pathway for the commercialisation of the systems. This study explores manufacturing strategies that can be considered for exploiting a family of eleven IPVFC systems. A survey and systems thinking approach were used to investigate the potential modularisation and supply chain management of the systems to achieve an optimal lean and agile manufacturing strategy. Results show that the Photovoltaic-Thermal-Separate Converter-Inverter-Battery System received 25% of the responses. The optimal manufacturing strategy depends on the overall business strategy of the firm. The 17% preference for System 1 was significant compared to four members of the family of IPVFC systems (Systems 2, 6, 8 and 9) that received only 2% of the responses, and there is a likelihood that the demand for System 1 will be among the top 42% of the total demand of all the systems. Overall, this study provides new insights into how the family of IPVFC systems can contribute to realising greater access to cleaner energy, by extension contributing to net-zero efforts using solar energy and solar hydrogen.
Assessing the Potential of Phase-Change Materials in Energy Retrofitting of Existing Buildings in a Mediterranean Climate
Authors: Stasi Roberto , Ruggiero Francesco , Berardi Umberto
Published: September 2024

The European Community has prioritized reducing energy consumption and improving energy efficiency in the building sector, along with ensuring increasingly high standards of thermal comfort, as key goals over recent decades. Given the impact of climate change, the rising frequency of extreme weather events, and the rapid shifts in peak demand during both winter and summer, buildings must efficiently respond to sudden and extreme temperature fluctuations while maintaining optimal indoor comfort. Phase-change materials (PCMs), which can adapt their thermophysical properties in response to external conditions, may offer a solution for enhancing building resilience to climate change. This paper evaluates the benefits of integrating various PCMs with plasterboard in the energy retrofit of a multi-family complex in a Mediterranean climate. The study examines the application of a PCM with a melting temperature of 25 °C at three different thicknesses (74.2 mm, 37.1 mm, and 20.8 mm) to external walls, ceilings, and both walls and ceilings simultaneously. Among the various applications, using the PCM on walls alone maximized heating savings as thickness increased (26.6%), while ceiling application maximized cooling energy savings (17.5%). Combined solutions offered the most balanced seasonal benefits, leading to the greatest overall energy reductions (24.1%).
Nano-Water-Alternating-Gas Simulation Study Considering Rock–Fluid Interaction in Heterogeneous Carbonate Reservoirs
Authors: Ko Seungmo , Park Hyeri , Jang Hochang
Published: September 2024

In carbonate reservoirs, nanoparticles can adhere to rock surfaces, potentially altering the rock wettability and modifying the absolute permeability. In the water-alternating-gas (WAG) process, the introduction of nanoparticles into the water phase, termed nano-water-alternating gas (NWAG), is a promising approach for enhancing oil recovery and CO2 storage. The NWAG process can alter rock wettability and absolute permeability through the adsorption of nanoparticles on the rock surface. This study investigated the efficiency of the NWAG method, which utilizes nanofluids in CO2-enhanced oil recovery (EOR) processes to simultaneously recover oil and store CO2 using 1D core and 3D heterogeneous reservoir models. The simulation results of the 1D core model showed that applying the NWAG method enhanced both oil recovery and CO2 storage efficiency by increasing to 3%. In a 3D reservoir model, a Dykstra–Parsons coefficient of 0.4 was selected to represent reservoir heterogeneity. Additionally, the capillary trapping of CO2 during WAG injection was computed using Larsen and Skauge’s three-phase relative permeability hysteresis model. A sensitivity analysis was performed using the NWAG ratio, slug size, injection period, injection cycle, and nanofluid concentration. The results confirmed an increase of 0.8% in oil recovery and 15.2% in CO2 storage compared with the conventional WAG process. This mechanism suggests that nanofluids can enhance oil recovery and expand CO2 storage, improving the efficiency of both the oil production rate and CO2 storage compared to conventional WAG methods.
Highly Stable Lattice Boltzmann Method with a 2-D Actuator Line Model for Vertical Axis Wind Turbines
Authors: Cacciali Luca , Hansen Martin O. L. , Rogowski Krzysztof
Published: September 2024

A 2-D Lattice Boltzmann Method, designed to ensure stability at high Reynolds numbers, is combined with an Actuator Line Model to compute the loads on a two-bladed vertical axis wind turbine. Tests on the kernel size at a high mesh resolution reveal that a size equal to half of the full chord length yields the most accurate results. The aerodynamic load solution is validated against a fully resolved Scale-Adaptive Simulation (SAS) output, demonstrating high correlation, and enabling an assessment of near wake and downstream effects. The model’s adaptability to various rotor operating conditions is confirmed through tests at high and low tip-speed ratios. Additionally, a Biot–Savart-based Vortex Model (VM) is employed for further comparison, showing good agreement with the Lattice Boltzmann output. The results indicate that the Highly Stable Lattice Boltzmann Method integrated with the Actuator Line Model enhances the accuracy of flow field resolution and effectively captures complex aerodynamic phenomena, making it a valuable tool for simulating vertical axis wind turbines.
Empowering Remote and Off-Grid Renewable Energy Communities: Case Studies in Congo, Australia, and Canada
Authors: Lemaire Julien , Castro Rui , Montemor Fátima
Published: September 2024

This paper aims to explore the feasibility of establishing self-sufficient electricity generation systems in off-grid remote communities using renewable energy sources. It provides an overview of current trends and developments in Renewable Energy Communities worldwide, with a focus on remote locations. To assess the technical feasibility, simulations were conducted using PVGIS for irradiation data and a load generator for energy consumption data. Different scenarios combining photovoltaic modules with lithium-ion battery systems were simulated using a dedicated optimization model developed in the PYTHON environment. The simulations aimed to size the entire system for three distinct locations: Congo, Australia, and Canada. The optimal number of PV modules determined for each location was 50 for Congo and 55 for Australia, and the battery system sizes were found to be 225 kWh and 150 kWh, respectively, admitting usual practices for the energy not supplied. The results obtained regarding Canada pointed to a system difficult to justify from an economic standpoint due to challenging weather conditions, namely, the existence of several consecutive days without irradiation.