bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing multiple infection control measures in a nursing home setting: a simulation study
Authors: Li Haomin , Sewell Daniel K. , Herman Ted , Pemmeraju Sriram V. , Segre Alberto M. , Miller Aaron C. , Polgreen Philip M. ,   for the CDC MInD-Healthcare Group
Published: March 2024

Objective:

Compare the effectiveness of multiple mitigation measures designed to protect nursing home residents from infectious disease outbreaks.

Design:

Agent-based simulation study.

Setting:

Simulation environment of a small nursing home.

Methods:

We collected temporally detailed and spatially fine-grained location information from nursing home healthcare workers (HCWs) using sensor motes. We used these data to power an agent-based simulation of a COVID-19 outbreak using realistic time-varying estimates of infectivity and diagnostic sensitivity. Under varying community prevalence and transmissibility, we compared the mitigating effects of (i) regular screening and isolation, (ii) inter-resident contact restrictions, (iii) reduced HCW presenteeism, and (iv) modified HCW scheduling.

Results:

Across all configurations tested, screening every other day and isolating positive cases decreased the attack rate by an average of 27% to 0.501 on average, while contact restrictions decreased the attack rate by an average of 35%, resulting in an attack rate of only 0.240, approximately half that of screening/isolation. Combining both interventions impressively produced an attack rate of only 0.029. Halving the observed presenteeism rate led to an 18% decrease in the attack rate, but if combined with screening every 6 days, the effect of reducing presenteeism was negligible. Altering work schedules had negligible effects on the attack rate.

Conclusions:

Universal contact restrictions are highly effective for protecting vulnerable nursing home residents, yet adversely affect physical and mental health. In high transmission and/or high community prevalence situations, restricting inter-resident contact to groups of 4 was effective and made highly effective when paired with weekly testing.
Case of Digna Ochoa & Family Members v. Mex. (Inter-Am. Ct. H.R.)
Authors: de la Vega Connie
Published: March 2024

This case addressed irregularities in the investigation of the death of Digna Ochoa y Plácido on October 19, 2001. The petition alleged that her death occurred in the context of harassment and attacks against human rights defenders in Mexico. The Inter-American Commission of Human Rights (the Commission) found that the state was responsible for violations of rights related to judicial protection and judicial guarantees under Articles 8(1) and 25 and personal integrity under Article 5 of the American Convention on Human Rights (ACHR).
Turbulent wake characteristics for a circular cylinder in proximity to a moving wall
Authors: Jiang Hongyi , Ju Xiaoying , Guo Zhen , Wang Lizhong
Published: March 2024

This study investigates the scenario of flow past a circular cylinder in proximity to a moving wall (or equally a body translating in still fluid parallel to a stationary wall). Fifty high-fidelity three-dimensional direct numerical simulations are performed over a parameter space of turbulent Reynolds numbers (Re) of 300 to 1000 combined with gap-to-diameter ratios (G/D) of 0.2 to 3. The flow, hydrodynamic and turbulence characteristics over the (Re, G/D) parameter space are examined in detail. Small-scale rib-like mode B structures and alternate vortex shedding are observed for all cases. The streamwise location for the vortex shedding (quantified by the wake recirculation length Lr) varies strongly with both Re and G/D. The variation of Lr with Re and G/D can be explained by the spanwise circulation

$\varGamma_z$

fed into the wake, where the variation trends of Lr and

$\varGamma_z$

are inversely correlated. The variations of the mean drag and fluctuating lift coefficients are also governed by the variations in Lr and

$\varGamma_z$

. The total kinetic energy in the wake region reduces drastically as G/D reduces below 0.8, which is contributed collectively by (i) reduction in the strength of the shed vortices, (ii) downstream movement of the location of vortex shedding and (iii) associated delayed generation of streamwise vortices. The present results on a moving wall also help to explain several flow and hydrodynamic characteristics reported in the literature for a stationary wall, because the moving wall eliminates the complex wall boundary layer and retains a ‘clean’ near-wall effect.
Firm performance feedback and organizational impression management: The moderating role of CEO overconfidence
Authors: Dadanlar Hazel H. , Vaswani Manisha M. , Al-Shammari Marwan , Banerjee Soumendra Nath
Published: March 2024

We propose that while positive performance feedback is positively related to firm sentiment, negative performance feedback is negatively associated with the firm sentiment. Additionally, overconfident Chief Executive Officers (CEOs) will improve the positive relationship between positive performance feedback and firm sentiment and reduce the negative relationship between negative performance feedback and firm sentiment. Using 7,182 firm-year observations for the 2004−2017 period, we show that positive performance feedback positively affects firm sentiment, and negative performance feedback negatively influences firm sentiment. We also found that higher levels of CEO overconfidence will minimize the negative impact of negative performance feedback on firm sentiment. Our research extends the current discourse on organizational impression management (proxied by firm sentiment) and CEO overconfidence research as we provide a nuanced relationship between firm performance feedback and organizational impression management. Our findings have theoretical and practical implications for corporate governance leaders and shareholders.
The immediate integration of semantic selectional restrictions of Chinese social hierarchical verbs with extralinguistic social hierarchical information in comprehension
Authors: Shi Yajiao , Zhou Tongquan , Zhao Simin , Sun Zhenghui , Zhu Zude
Published: March 2024

Social hierarchical information impacts language comprehension. Nevertheless, the specific process underlying the integration of linguistic and extralinguistic sources of social hierarchical information has not been identified. For example, the Chinese social hierarchical verb 赡养, /shan4yang3/, ‘support: provide for the needs and comfort of one’s elders’, only allows its Agent to have a lower social status than the Patient. Using eye-tracking, we examined the precise time course of the integration of these semantic selectional restrictions of Chinese social hierarchical verbs and extralinguistic social hierarchical information during natural reading. A 2 (Verb Type: hierarchical vs. non-hierarchical) × 2 (Social Hierarchy Sequence: match vs. mismatch) design was constructed to investigate the effect of the interaction on early and late eye-tracking measures. Thirty-two participants (15 males; age range: 18–24 years) read sentences and judged the plausibility of each sentence. The results showed that violations of semantic selectional restrictions of Chinese social hierarchical verbs induced shorter first fixation duration but longer regression path duration and longer total reading time on sentence-final nouns (NP2). These differences were absent under non-hierarchical conditions. The results suggest that a mismatch between linguistic and extralinguistic social hierarchical information is immediately detected and processed.
Italian women workers and women activists between home and factory: the struggle against labour precarity (1950s–1970s)
Authors: Betti Eloisa
Published: March 2024

From a gender historical perspective, labour precarity constitutes a long-term phenomenon. Women's work represents a privileged observatory to understand how instability and precarity also characterised the cycle of economic and industrial expansion of the 1950s and 1960s. The article compares the conditions of female factory workers with those of home-based workers, a traditionally invisible category of workers, who between the 1960s and 1970s promoted demonstrations and protests with the support of trade unions, women's associations and local institutions. Changes in the subjectivity of women workers and homeworkers, whose demands often came together and gave rise to joint protests, not only became part of broader discussions on the relationship between industrial crisis and precariousness, but also generated discourses on specific forms of work that are now central to debates on flexible/precarious work such as part-time work.
Photographing Sites of Nazi Violence, 1933–1945
Authors: Crew David
Published: March 2024

By far the greatest number of photographs of Nazi sites of violence were taken by the perpetrators. Some Jews did work as official photographers in the ghettoes, but during deportations, in the camps and extermination centers, and at the sites of mass shootings, only Gestapo officers, SS men and women, or other authorized personnel were officially permitted to use cameras. In the Mauthausen concentration camp, for example, as Lukas Meissel explains in his contribution to the excellent collection of essays,Fotografien aus den Lagern des NS-Regimes. Beweissicherung und ästhethische Praxis, “only members of the so-calledErkennungsdienst(identification department) were allowed to take photographs.”1These photographs “do not reflect the reality of the camp” (45). They seldom confront us directly with Nazi violence. Instead, these pictures offer (false) images of frictionless operations, visual testimony to the efficiency of the perpetrators, usually meant to impress their superiors.
Evidence of distribution overlap between Atlantic and Baltic grey seals
Authors: Galatius Anders , Olsen Morten Tange , Allentoft-Larsen Marc , Balle Jeppe Dalgaard , Kyhn Line Anker , Sveegaard Signe , Teilmann Jonas
Published: March 2024

Grey seals from both the Atlantic and Baltic Sea subspecies are recovering from dramatic declines and recolonising former ranges, potentially leading to overlapping distributions and an emerging subspecies transition zone in Kattegat between Denmark and Sweden. The two subspecies have asynchronous moulting and pupping seasons. We present aerial survey data from 2011 to 2023 in Danish Kattegat during the Atlantic subspecies' moulting (March–April) and pupping (December–January) seasons, as well as the Baltic subspecies' moulting season (May–June). During the Atlantic subspecies' peak moulting season, 82% of the grey seals were recorded north of the island of Læsø (N57°18′, E11°00′). In contrast, during the Baltic moulting season in those years, only 9% of the grey seals were recorded here. This indicates a predominance of Atlantic grey seals in the north and Baltic grey seals in central and southern Kattegat. In 2022 and 2023, three pups were recorded around Læsø during early January, which coincides with the pupping season of northern Wadden Sea grey seals. Previously, pups have been recorded in the same locations during the Baltic pupping season, which demonstrates overlapping breeding ranges. Grey seals are known to have plasticity in the timing of pupping indicated by a west to east cline of progressively later pupping in the eastern North Atlantic. Historical sources document that the Baltic pupping season in Kattegat was earlier than it has been in recent years. Thus, the expanding ranges may be associated with convergence of Atlantic and Baltic subspecies' pupping seasons and potential hybridisation in this emerging transition zone.
Overcoming a stigmatic past: National Central University students in Nanjing, China, and the politics of wartime history
Authors: Henshaw Jonathan
Published: March 2024

The Japanese empire’s occupation of China during the Second World War left a complex and bitter legacy in postwar Chinese society. This article examines the occupation and its legacies at the grassroots, taking university students in Nanjing as a case study in occupation history and ‘bottom-up’ wartime commemoration. These young people, who studied at National Central University (NCU) under the Japanese-backed Reorganized National Government of Wang Jingwei, organized three protest movements between 1940 and 1945, defying puppet authorities, Japanese forces, and, after the war, the returning Chongqing Nationalist government, as they campaigned against corruption, opium sales, and discriminatory treatment over their status as ‘bogus students’ who supposedly received Japanese ‘enslavement education’ from a collaborationist regime. In the 1980s, after decades of marginalization under the People’s Republic of China, these former protestors began holding reunions, documenting their experiences, and campaigning for recognition from Nanjing University, which eventually recognized them as alumni. Drawing primarily on privately printed alumni memoirs and commemorative volumes, this article positions the protests in the history of youth activism in Nanjing. That NCU students were able to rehabilitate themselves was due to their own organizational prowess and a sympathetic reception from the leadership of a cash-strapped Nanjing University, though the interests of fellow alumnus Jiang Zemin and the Communist Party-state still set the parameters of historical memory. In this, the example of the Nanjing students complicates the top-down role of the state, as described in much previous scholarship on Chinese wartime commemoration, in producing politically motivated nationalist narratives of wartime history.
The molecular epidemiology of hepatitis E virus genotype 3 in Canada
Authors: Borlang Jamie , Murphy Donald , Harlow Jennifer , Osiowy Carla , Nasheri Neda
Published: March 2024

Autochthonous hepatitis E virus (HEV) infection is increasingly reported in industrialized countries and is mostly associated with zoonotic HEV genotype 3 (HEV-3). In this study, we examined the molecular epidemiology of 63 human clinical HEV-3 isolates in Canada between 2014 and 2022. Fifty-five samples were IgM positive, 45 samples were IgG positive and 44 were IgM and IgG positive. The majority of the isolates belong to the subtypes 3a, 3b, and 3j, with high sequence homology to Canadian swine and pork isolates. There were a few isolates that clustered with subtypes 3c, 3e, 3f, 3h, and 3g, and an isolate from chronic infection with a rabbit strain (3ra). Previous studies have demonstrated that the isolates from pork products and swine from Canada belong to subtypes 3a and 3b, therefore, domestic swine HEV is likely responsible for the majority of clinical HEV cases in Canada and further support the hypothesis that swine serve as the main reservoirs for HEV-3 infections. Understanding the associated risk of zoonotic HEV infection requires the establishment of sustainable surveillance strategies at the interface between humans, animals, and the environment within a One-Health framework.
Interorganizational Knowledge Transfer in Mass Gatherings: Exploring the Health and Safety Stakeholders’ Perceptions Participating in the Athens Marathon
Authors: Bistaraki Angeliki , Stefanopoulos Nikos
Published: March 2024

Introduction:

Mass gatherings (MGs) usually represent significant challenges for the public health and safety sector of the host cities. Organizing a safe and successful mass event highly depends on the effective collaboration among different public and private organizations. It is necessary to establish successful coordination to ensure that all the key stakeholders understand their respective roles and responsibilities. The inconsistency between the variety of participating agencies because of their different culture can result in delays in decision making. Interorganizational knowledge transfer can improve the success of the event; however, knowledge transfer among professionals and agencies in MGs is not well-documented.

Objective:

This study used the 2018 Athens Marathon as the empirical setting to examine how interorganizational knowledge transfer was perceived among the multiple public health and safety professionals during the planning stage of the event.

Methods:

Data comprised 18 semi-structured, in-depth interviews with key informants, direct observations of meetings, and documentary analysis. Open coding and thematic analysis were used to analyze the data.

Results:

Findings indicated that sharing the acquired knowledge was a necessary and challenging step to create an enabling collaborative environment among interacting organizations. Experiential learning was identified as a significant factor, which helped promote joint understanding and partnership work. Informal interpersonal exchanges and formal knowledge transfer activities facilitated knowledge sharing across organizational boundaries, helping to break down silos.

Conclusion:

Interorganizational knowledge transfer is a necessary step to achieve joint understanding and create an environment where interaction among agencies can be more effective. The study findings can be beneficial for organizers of marathons and other mass sporting events to support valuable interorganizational collaboration and conduct a safe event.
Breastfeeding moderates the association of maternal pre-pregnancy nutritional status with offspring body composition at 30 years
Authors: Horta Bernardo L. , Coca Kelly P. , Desai Mina , Dias Mariane S. , B. Jaccottet Manoella , Ross Michael G.
Published: March 2024

Maternal pre-pregnancy body mass index is positively associated with offspring obesity, even at adulthood, whereas breastfeeding decreases the risk of obesity. The present study was aimed at assessing whether breastfeeding moderates the association of maternal pre-pregnancy body mass index with offspring body composition at adulthood, using data from 3439 subjects enrolled in a southern Brazilian birth cohort. At 30 years of age, maternal pre-pregnancy body mass index was positively associated with offspring prevalence of obesity, abdominal obesity, as well as body mass index and fat and lean mass index. Breastfeeding moderated the association of maternal pre-pregnancy obesity with offspring adiposity at 30 years of age. For those breastfed<6 months, body mass index was 4.13 kg/m2 (95% confidence interval: 2.98; 5.28) higher among offspring of obese mothers, in relation to offspring of normal weight mothers, whereas among those breastfed≥6 months the magnitude of the difference was small [2.95 kg/m2 (95% confidence interval: 1.17; 4.73)], p-value for interaction = 0.03. Concerning obesity, among those who had been breastfed < 6 months, the prevalence of obesity was 2.56 (95% confidence interval: 1.98; 3.31) times higher among offspring of obese mothers. On the other hand, among those who were breastfed ≥ 6 months, the prevalence of obesity was 1.82 (95% confidence interval: 1.09; 3.04) times higher among offspring of obese mothers. Therefore, among overweight mothers breastfeeding for more than 6 months should be supported, as it may mitigate the consequences of maternal overweight on offspring body composition.
Control of multiple-herbicide-resistant waterhemp (Amaranthus tuberculatus) with acetochlor-based herbicide mixtures in corn
Authors: Symington Hannah E. , Soltani Nader , Kaastra Allan C. , Hooker David C. , Robinson Darren E. , Sikkema Peter H.
Published: March 2024

Waterhemp is a summer annual, broadleaf weed with high fecundity, short seed longevity in the soil, and wide genetic diversity. Populations have evolved resistance to five herbicide modes of action (Groups 2, 5, 9, 14, and 27), which are present across southern Ontario; this has increased the challenge of controlling this competitive weed species in corn, the most important grain crop produced worldwide and the highest-value agronomic crop in Ontario. Acetochlor is a Group 15 soil-applied residual herbicide that has activity on many grass and broadleaf weeds but has yet to be registered in Canada. The objective of this study was to ascertain whether mixtures of acetochlor with flumetsulam, dicamba, atrazine, isoxaflutole/diflufenican, or mesotrione + atrazine applied preemergence would increase the control of multiple-herbicide-resistant (MHR) waterhemp in corn. Five field trials were conducted between 2022 and 2023. No corn injury was observed. Acetochlor applied alone controlled MHR waterhemp 97% 12 wk after application (WAA). All herbicide mixtures controlled MHR waterhemp similarly at ≥98% 12 WAA; there were no differences among herbicide mixtures. Flumetsulam, dicamba, and atrazine provided lower MHR waterhemp control than all other herbicide treatments and did not reduce density or biomass. Acetochlor reduced waterhemp density 98%, while the acetochlor mixtures reduced density similarly at 99% to 100%. This study concludes that the acetochlor mixtures evaluated provide excellent waterhemp control; however, control was not greater than acetochlor alone. Herbicide mixtures should be used as a best management practice to mitigate the evolution of herbicide resistance.
Molybdenum Isotope Fingerprinting of Microbial Sulfate Reduction in Seep Carbonate Rocks
Authors: Jia Zice , Hu Yu , Bayon Germain , Peckmann Jörn , Wang Xudong , Gong Shanggui , Li Jie , Roberts Harry H. , Chen Duofu , Feng Dong
Published: March 2024

Understanding the interaction between molybdenum (Mo) and organic matter during microbial sulfate reduction is critical for the use of Mo to reconstruct marine redox conditions throughout Earth's history. However, little is known about Mo isotope fractionation and how it relates to organic matter remineralization during microbial sulfate reduction. Here, we report Mo abundances and isotopic (δ98Mo) compositions for bulk‐rock, non‐lithogenic and sequentially extracted fractions, including carbonate (carb), pyrite, and organic matter (OM), of seep carbonate rocks. Our data indicate that the difference between δ98Mocarb and δ98MoOM (Δ98Mocarb‐OM) displays significant variability in the studied samples, ranging between 0.72 and 1.01‰. Remarkably, the obtained Δ98Mocarb‐OM values indicate correlative trends with stable carbon isotope ratios and bulk abundances of (a) total organic carbon, (b) Mo, and (c) pyrite in seep carbonates, which we interpret as reflecting sustained adsorption of isotopically light Mo onto organic matter during enhanced sulfate reduction. On this basis, we put forward the concept that Δ98Mocarb‐OM of authigenic carbonate rocks can be used as a measure of the intensity of sulfate reduction and for reconstructing past interactions between Mo and organic matter in marine sediments.
Whistler‐Mode Waves Inside Short Large‐Amplitude Magnetic Field Structures: Characteristics and Generation Mechanisms
Authors: Bai Shi‐Chen , Shi Quanqi , Shen Xiao‐Chen , Tian Anmin , Zhang Hui , Guo Ruilong , Wang Mengmeng , Degeling Alexander W. , Bu Yude , Zhang Shuai , Ma Xiao
Published: March 2024

Short large‐amplitude magnetic structures (SLAMS) frequently appear near the bow shock. Inside steepening SLAMS, whistler‐mode waves are coherently generated at their leading edges. These waves are crucial for electron dynamics, energy conversion and magnetic reconnection near the shock. Nevertheless, the characteristics and generation of the whistler‐mode waves inside SLAMS are still unclear. In this study, we conducted a statistical analysis of whistler‐mode waves within SLAMS near the Earth's bow shock to investigate their properties and generation mechanisms. We found that these waves are mainly excited by electron temperature anisotropy with 99% of them falling below the nonlinear resonant threshold. The combination of a low background magnetic field and intense steepening at SLAMS' leading edge makes it the main source region of whistler‐mode waves and may induce the nonlinear resonance of whistler‐mode waves.
Enhanced Mineral Preservation Rather Than Microbial Residue Production Dictates the Accrual of Mineral‐Associated Organic Carbon Along a Weathering Gradient
Authors: Zhu Erxiong , Liu Zongguang , Ma Lixiao , Luo Jianing , Kang Enze , Wang Ya , Zhao Yunpeng , Jia Juan , Feng Xiaojuan
Published: March 2024

Mineral preservation and microbial residue production are vital for the accumulation of mineral‐associated organic carbon (MAOC) in soils. However, their relative importance and interactive effects remain unclear. Here MAOC content and composition are analyzed in tandem with soil mineral and microbial attributes along a weathering gradient on a volcanic soil sequence. We find that MAOC content increases with increasing mineral weathering states, accompanied by increasing microbial contribution to MAOC. Mineral attributes rather than microbial physiological traits are strongly related to MAOC contents, suggesting that weathering‐enhanced mineral preservation capacity overrides microbial residue production in governing MAOC accumulation by increasing reactive minerals. Furthermore, mineral attributes have a strong interactive effect with microbial traits on MAOC accumulation and composition, likely related to increasing fungal abundance in the microbial community with increasing weathering. These findings highlight that mineral weathering may effectively boost persistent SOC in synergy with microbial conversion in the long term.
Academic performance in moderately and late preterm children in the United States: are they catching up?
Authors: Lock Nicole E. , DeBoer Mark D. , Scharf Rebecca J. , Miller Sarah E.
Published: March 2024

Objective

To determine whether preterm birth of 32–36 6/7 weeks gestation affected school performance from kindergarten through fifth grade.

Study design

We assessed 14350 term infants and 1195 32–36 6/7 weeks gestation infants followed in the Early Childhood Longitudinal Study Kindergarten 2011 cohort for classroom performance in kindergarten-fifth grade. Multivariable regression was performed for comparisons, and data were weighted to be representative of the US population.

Results

Children born 35–36 6/7 weeks gestation had no significant difference in their academic scores or performance, while 32–34 6/7 weeks’ children had lower academic scores and teacher performance scores when compared to term children. Children born between 32 and 36 6/7 weeks gestation had higher odds of individualized education plan needs and had learning disability diagnoses compared to term children.

Conclusions

Children born between 32 and 34 6/7 weeks gestation have poor school performance compared to term children. Children born between 32 and 36 6/7 weeks gestation are at risk for learning disabilities and likely benefit from continued support and services to improve achievement throughout school.
The impact of adult neurogenesis on affective functions: of mice and men
Authors: Alonso Mariana , Petit Anne-Cécile , Lledo Pierre-Marie
Published: March 2024

In most mammals, new neurons are not only produced during embryogenesis but also after birth. Soon after adult neurogenesis was discovered, the influence of recruiting new neurons on cognitive functions, especially on memory, was documented. Likewise, the late process of neuronal production also contributes to affective functions, but this outcome was recognized with more difficulty. This review covers hypes and hopes of discovering the influence of newly-generated neurons on brain circuits devoted to affective functions. If the possibility of integrating new neurons into the adult brain is a commonly accepted faculty in the realm of mammals, the reluctance is strong when it comes to translating this concept to humans. Compiling data suggest now that new neurons are derived not only from stem cells, but also from a population of neuroblasts displaying a protracted maturation and ready to be engaged in adult brain circuits, under specific signals. Here, we discuss the significance of recruiting new neurons in the adult brain circuits, specifically in the context of affective outcomes. We also discuss the fact that adult neurogenesis could be the ultimate cellular process that integrates elements from both the internal and external environment to adjust brain functions. While we must be critical and beware of the unreal promises that Science could generate sometimes, it is important to continue exploring the potential of neural recruitment in adult primates. Reporting adult neurogenesis in humankind contributes to a new vision of humans as mammals whose brain continues to develop throughout life. This peculiar faculty could one day become the target of treatment for mental health, cognitive disorders, and elderly-associated diseases. The vision of an adult brain which never stops integrating new neurons is a real game changer for designing new therapeutic interventions to treat mental disorders associated with substantial morbidity, mortality, and social costs.
The congenital hearing phenotype in GJB2 in Queensland, Australia: V37I and mild hearing loss predominates
Authors: Kriukelis Rebecca , Gabbett Michael T. , Beswick Rachael , McInerney-Leo Aideen M. , Driscoll Carlie , Liddle Karen
Published: March 2024

GJB2 was originally identified in severe, non-syndromic sensorineural hearing loss (SNHL), but was subsequently associated with mild and moderate SNHL. Given the increasing utilisation of genetic testing pre-conceptually, prenatally, and neonatally, it is crucial to understand genotype-phenotype correlations. This study evaluated the nature and frequency of GJB2 variants in an Australian paediatric population with varying degrees of SNHL ascertained through newborn hearing screening. Audiograms from individuals with GJB2 variants and/or a GJB6 deletion (GJB6-D13S11830) were retrospectively reviewed (n = 127). Two-thirds were biallelic (homozygous/compound heterozygous) for pathogenic/likely pathogenic variants of GJB2 and/or GJB6 (n = 80). The most frequent variant was c.109 G > A, followed by c.35delG and c.101 T > C. Compared to biallelic carriage of other GJB2 variants, c.109 G > A positive individuals (homozygous/compound heterozygous) were more likely to have mild HL at their initial and latest audiograms (p = 0.0004). Biallelic carriage of c.35delG was associated with moderately-severe or greater SNHL at both initial and latest audiograms (p = 0.007). The c.101 T > C variant presented with milder SNHL and U-shaped audiograms (p = 0.02). In this agnostically identified cohort, mild SNHL predominated in GJB2/GJB6 carriers in contrast to previous studies targeting individuals with significant loss. Consequently, c.109 G > A, associated with milder phenotypes, was the most frequent. This study provides valuable data to support prognostic confidence in genetic counselling.
Competence for neural crest induction is controlled by hydrostatic pressure through Yap
Authors: Alasaadi Delan N. , Alvizi Lucas , Hartmann Jonas , Stillman Namid , Moghe Prachiti , Hiiragi Takashi , Mayor Roberto
Published: March 2024

Embryonic induction is a key mechanism in development that corresponds to an interaction between a signalling and a responding tissue, causing a change in the direction of differentiation by the responding tissue. Considerable progress has been achieved in identifying inductive signals, yet how tissues control their responsiveness to these signals, known as competence, remains poorly understood. While the role of molecular signals in competence has been studied, how tissue mechanics influence competence remains unexplored. Here we investigate the role of hydrostatic pressure in controlling competence in neural crest cells, an embryonic cell population. We show that neural crest competence decreases concomitantly with an increase in the hydrostatic pressure of the blastocoel, an embryonic cavity in contact with the prospective neural crest. By manipulating hydrostatic pressure in vivo, we show that this increase leads to the inhibition of Yap signalling and impairs Wnt activation in the responding tissue, which would be required for neural crest induction. We further show that hydrostatic pressure controls neural crest induction in amphibian and mouse embryos and in human cells, suggesting a conserved mechanism across vertebrates. Our work sets out how tissue mechanics can interplay with signalling pathways to regulate embryonic competence.
Local origin of excitatory–inhibitory tuning equivalence in a cortical network
Authors: Duszkiewicz Adrian J. , Orhan Pierre , Skromne Carrasco Sofia , Brown Eleanor H. , Owczarek Eliott , Vite Gilberto R. , Wood Emma R. , Peyrache Adrien
Published: March 2024

The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields of excitatory neurons are often finely tuned to encoded features, but the principles governing the tuning of inhibitory neurons remain elusive. In this study, we recorded populations of neurons in the mouse postsubiculum (PoSub), where the majority of excitatory neurons are head-direction (HD) cells. We show that the tuning of fast-spiking (FS) cells, the largest class of cortical inhibitory neurons, was broad and frequently radially symmetrical. By decomposing tuning curves using the Fourier transform, we identified an equivalence in tuning between PoSub-FS and PoSub-HD cell populations. Furthermore, recordings, optogenetic manipulations of upstream thalamic populations and computational modeling provide evidence that the tuning of PoSub-FS cells has a local origin. These findings support the notion that the equivalence of neuronal tuning between excitatory and inhibitory cell populations is an intrinsic property of local cortical networks.
The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions
Authors: Chen Changwan , Altafi Mahsa , Corbu Mihaela-Anca , Trenk Aleksandra , van den Munkhof Hanna , Weineck Kristin , Bender Franziska , Carus-Cadavieco Marta , Bakhareva Alisa , Korotkova Tatiana , Ponomarenko Alexey
Published: March 2024

Innate behaviors meet multiple needs adaptively and in a serial order, suggesting the existence of a hitherto elusive brain dynamics that brings together representations of upcoming behaviors during their selection. Here we show that during behavioral transitions, possible upcoming behaviors are encoded by specific signatures of neuronal populations in the lateral hypothalamus (LH) that are active near beta oscillation peaks. Optogenetic recruitment of intrahypothalamic inhibition at this phase eliminates behavioral transitions. We show that transitions are elicited by beta-rhythmic inputs from the prefrontal cortex that spontaneously synchronize with LH ‘transition cells’ encoding multiple behaviors. Downstream of the LH, dopamine neurons increase firing during beta oscillations and also encode behavioral transitions. Thus, a hypothalamic transition state signals alternative future behaviors, encodes the one most likely to be selected and enables rapid coordination with cognitive and reward-processing circuitries, commanding adaptive social contact and eating behaviors.
Exploring urban land surface temperature using spatial modelling techniques: a case study of Addis Ababa city, Ethiopia
Authors: Eshetie Seyoum Melese
Published: March 2024

Urban areas worldwide are experiencing escalating temperatures due to the combined effects of climate change and urbanization, leading to a phenomenon known as urban overheating. Understanding the spatial distribution of land surface temperature (LST) and its driving factors is crucial for mitigation and adaptation of urban overheating. So far, there has been an absence of investigations into spatiotemporal patterns and explanatory factors of LST in the city of Addis Ababa. The study aims to determine the spatial patterns of land surface temperature, analyze how the relationships between LST and its factors vary across space, and compare the effectiveness of using ordinary least squares and geographically weighted regression to model these connections. The findings showed that the spatial patterns of LST show statistically significant hot spot zones in the north-central parts of the study area (Moran’s I = 0.172). The relationship between LST and its explanatory variables were modelled using ordinary least square model and thereby tested if there is spatial dependence in the model using the Koenker (BP) Statistic.The result revealed non-stationarity (p = 0.000) and consequently geographically weighted regression was employed to compare the performance with OLS. The research has revealed that, GWR (R2 = 0.57, AIC = 1052.1) is more effective technique than OLS (R2 = 0.42, AIC = 2162.0) for studying the relationship LST and the selected explanatory variables. The use of GWR has improved the accuracy of the model by capturing the spatial heterogeneity in the relationship between land surface temperature and its explanatory variables. The relationship between LST and its explanatory variables were modelled using ordinary least square model and thereby tested if there is spatial dependence in the model using the Koenker (BP) Statistic. The result revealed non-stationarity ((p = 0.000) and consequently geographically weighted regression was employed to compare the performance with OLS. The research has revealed that, GWR (R2 = 0.57, AIC = 1052.1) is more effective technique than OLS (R2 = 0.42, AIC = 2162.0) for studying the relationship LST and the selected explanatory variables. The use of GWR has improved the accuracy of the model by capturing the spatial heterogeneity in the relationship between land surface temperature and its explanatory variables. Consequently, Localized understanding of the spatial patterns and the driving factors of LST has been formulated.
New coordinated drive mode switching strategy for distributed drive electric vehicles with energy storage system
Authors: Oubelaid Adel , Kakouche Khoudir , Belkhier Youcef , Khosravi Nima , Taib Nabil , Rekioua Toufik , Bajaj Mohit , Rekioua Djamila , Tuka Milkias Berhanu
Published: March 2024

High performance and comfort are key features recommended in hybrid electric vehicle (HEV) design. In this paper, a new coordination strategy is proposed to solve the issue of undesired torque jerks and large power ripples noticed respectively during drive mode commutations and power sources switching. The proposed coordinated switching strategy uses stair-based transition function to perform drive mode commutations and power source switching’s within defined transition periods fitting the transient dynamics of power sources and traction machines. The proposed technique is applied on a battery/ supercapacitor electric vehicle whose traction is ensured by two permanent magnet synchronous machines controlled using direct torque control and linked to HEV front and rear wheels. Simulation results highlight that the proposed coordinated switching strategy has a noteworthy positive impact on enhancing HEV transient performance as DC bus fluctuations were reduced to a narrow band of 6 V and transient torque ripples were almost suppressed.
An adenosine derivative promotes mitochondrial supercomplexes reorganization and restoration of mitochondria structure and bioenergetics in a diethylnitrosamine-induced hepatocellular carcinoma model
Authors: García-Carrillo Rosendo , Molina-Pelayo Francisco A. , Zarate-Lopez David , Cabrera-Aguilar Alejandro , Ortega-Domínguez Bibiana , Domínguez-López Mariana , Chiquete-Félix Natalia , Dagnino-Acosta Adan , Velasco-Loyden Gabriela , Chávez Enrique , Castro-Sánchez Luis , de Sánchez Victoria Chagoya
Published: March 2024

Hepatocellular carcinoma (HCC) progression is associated with dysfunctional mitochondria and bioenergetics impairment. However, no data about the relationship between mitochondrial supercomplexes (hmwSC) formation and ATP production rates in HCC are available. Our group has developed an adenosine derivative, IFC-305, which improves mitochondrial function, and it has been proposed as a therapeutic candidate for HCC. We aimed to determine the role of IFC-305 on both mitochondrial structure and bioenergetics in a sequential cirrhosis-HCC model in rats. Our results showed that IFC-305 administration decreased the number and size of liver tumors, reduced the expression of tumoral markers, and reestablished the typical architecture of the hepatic parenchyma. The livers of treated rats showed a reduction of mitochondria number, recovery of the mtDNA/nDNA ratio, and mitochondrial length. Also, IFC-305 increased cardiolipin and phosphatidylcholine levels and promoted hmwSC reorganization with changes in the expression levels of hmwSC assembly-related genes. IFC-305 in HCC modified the expression of several genes encoding elements of electron transport chain complexes and increased the ATP levels by recovering the complex I, III, and V activity. We propose that IFC-305 restores the mitochondrial bioenergetics in HCC by normalizing the quantity, morphology, and function of mitochondria, possibly as part of its hepatic restorative effect.
Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study
Authors: You Yanwei , Chen Yuquan , Liu Ruidong , Zhang Yangchang , Wang Meiqing , Yang Zihao , Liu Jianxiu , Ma Xindong
Published: March 2024

Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting healthy aging. This study aims to (i) identify the sleep duration trend in US adults; (ii) investigate the relationship between sleep duration and phenotypic age; and (iii) explore the role of exercise in this relationship. Phenotypic age as a novel index was calculated according to biomarkers collected from US adults based on the National Health and Nutrition Examination Survey (NHANES). Sleep information was self-reported by participants and discerned through individual interviews. The principal analytical method employed was weighted multivariable linear regression modeling, which accommodated for the complex multi-stage sampling design. The potential non-linear relationship was explored using a restricted cubic spline (RCS) model. Furthermore, subgroup analyses evaluated the potential effects of sociodemographic and lifestyle factors on the primary study outcomes. A total of 13,569 participants were finally included in, thereby resulting in a weighted population of 78,880,615. An examination of the temporal trends in sleep duration revealed a declining proportion of individuals with insufficient and markedly deficient sleep time since the 2015–2016 cycle. Taken normal sleep group as a reference, participants with extreme short sleep [β (95% CI) 0.582 (0.018, 1.146), p = 0.044] and long sleep [β (95% CI) 0.694 (0.186, 1.203), p = 0.010] were both positively associated with phenotypic age using the fully adjusted model. According to the dose–response relationship between sleep duration and phenotypic age, long sleep duration can benefit from regular exercise activity, whereas short sleep duration with more exercise tended to have higher phenotypic age. There is an inverted U-shaped relationship between short and long sleep durations and phenotypic age. This study represents an important step forward in our understanding of the complex relationship between sleep and healthy aging. By shedding light on this topic and providing practical exercise recommendations for promoting healthy sleep habits, researchers can help individuals live longer, healthier, and more fulfilling lives.
Effects of different nitrogen applications and straw return depth on straw microbial and carbon and nitrogen cycles in paddy fields in the cool zone
Authors: Liu Lin , Cheng Ming , Jin Jingyi , Fu Minjie
Published: March 2024

Straw is an important source of organic fertilizer for soil enrichment, however, the effects of different nitrogen(N) application rates and depths on straw decomposition microorganisms and carbon and nitrogen cycling under full straw return conditions in cool regions of Northeast China are not clear at this stage. In this paper, we applied macro-genome sequencing technology to investigate the effects of different N application rates (110 kg hm−2, 120 kg hm−2, 130 kg hm−2, 140 kg hm−2, 150 kg hm−2) and depths (0–15 cm, 15–30 cm) on straw decomposing microorganisms and N cycling in paddy fields in the cool zone of Northeast China. The results showed that (1) about 150 functional genes are involved in the carbon cycle process of degradation during the degradation of returned straw, of which the largest number of functional genes are involved in the methane production pathway, about 42, the highest abundance of functional genes involved in the citric acid cycle pathway. There are 22 kinds of functional genes involved in the nitrogen cycle degradation process, among which there are more kinds involved in nitrogen fixation, with 4 kinds. (2) High nitrogen application (150 kg hm−2) inhibited the carbon and nitrogen conversion processes, and the abundance of straw-degrading microorganisms and nitrogen-cycling functional genes was relatively high at a nitrogen application rate of 130 kg hm−2. (3) Depth-dependent heterogeneity of the microbial community was reduced throughout the vertical space. At 71 days of straw return, the nitrogen cycling function decreased and some carbon functional genes showed an increasing trend with the increase of straw return depth. The nitrogen cycle function decreased with the increase of straw returning depth. The microbial community structure was best and the abundance of functional genes involved in the nitrogen cycling process was higher under the conditions of 0–15 cm of returning depth and 130 kg hm−2 of nitrogen application.
Analysis and comparative study of a deterministic mathematical model of SARS-COV-2 with fractal-fractional operators: a case study
Authors: Kubra Khadija Tul , Ali Rooh , Alqahtani Rubayyi Turki , Gulshan Samra , Iqbal Zahoor
Published: March 2024

In this paper, we investigate a fractal-fractional-order mathematical model with the influence of hospitalized patients and the impact of vaccination with fractal-fractional operators. The respective derivatives are considered in the Caputo, Caputo Fabrizio, and Atangana–Baleanu senses of fractional order $$ \alpha $$
α
and fractal dimension $$ \tau $$
τ
. For the proposed problem, some results regarding basic reproduction number and stability are given. Using the next-generation matrix approach, we have investigated the global and local stability of several types of equilibrium points. We provide a detailed analysis of the existence and uniqueness of the solution. Moreover, we fit the model with the real data of Pakistan from June 01, 2020, till March 24, 2021. Then, we use the fractal-fractional derivative to find a numerical solution for the model. MATLAB software is used for numerical illustration. Graphical presentations corresponding to different parameteric values are given as well.