bluuebunny/crossref_metadata_2025 huggingface dataset:
Effector memory CD8 T-cells as a novel peripheral blood biomarker for activated T-cell pediatric acute liver failure
Authors: Chapin Catherine A. , Burn Thomas M. , Diamond Tamir , Loomes Kathleen M. , Alonso Estella M. , Behrens Edward M.
Published: June 2023

A distinct phenotype of pediatric acute liver failure (PALF) has been identified, labeled activated T-cell hepatitis. These patients, previously included within the indeterminate group, have evidence of systemic immune activation and liver biopsy specimens with dense infiltration of CD8+ T-cells. We aimed to evaluate the peripheral blood T-cell phenotype in PALF patients with activated T-cell hepatitis compared to indeterminate cause. PALF patients with unknown etiology age 1–17 years were prospectively enrolled between 2017–2020. Within the unknown group, patients were classified as either activated T-cell hepatitis if they had a liver biopsy with dense or moderate CD8 staining and an elevated soluble interleukin-2 receptor level, or they were classified as indeterminate if they did not meet these criteria. Whole blood was collected for flow cytometry and T-cell phenotyping. Four patients with activated T-cell hepatitis and 4 patients with indeterminate PALF were enrolled. Activated T-cell hepatitis patients had significantly greater percentage of CD8 T-cells that were effector memory (TEM) phenotype compared to indeterminate PALF patients (median 66.8% (IQR 57.4–68.7) vs 19.1% (IQR 13.4–25.2), P = 0.03). In addition, CD8+ TEM cells in activated T-cell hepatitis patients were significantly more likely to be CD103 positive, a marker of tissue resident memory T-cells, compared to indeterminate PALF patients (median 12.4% (IQR 9.5–14.7) vs 4.7% (IQR 4.5–5.3), P = 0.03). We found patients with activated T-cell hepatitis can be identified by the unique pattern of increased percentage of peripheral blood effector memory CD8+ CD103+ T-cells. These findings will guide future studies exploring the T-cell phenotype for these patients and whether they may respond to directed immunosuppressive therapies.
Clinicians’, patients’ and carers’ perspectives on borderline personality disorder in Pakistan: A mixed methods study protocol
Authors: Hedemann Thea Lynne , Asif Muqaddas , Aslam Huma , Maqsood Aneela , Bukhsh Ameer , Kiran Tayyeba , Ahsan Umair , Shahzad Salman , Zaheer Juveria , Lane Steven , Chaudhry Nasim , Husain M. Ishrat , Husain M. Omair
Published: June 2023

Borderline Personality Disorder (BPD) is a condition characterised by significant social and occupational impairment and high rates of suicide. In high income countries, mental health professionals carry negative attitudes towards patients with BPD, find it difficult to work with patients with BPD, and even avoid seeing these patients. Negative attitudes and stigma can cause patients to fear mistreatment by health care providers and create additional barriers to care. Patients’ self-stigma and illness understanding BPD also affects treatment engagement and outcomes; better knowledge about mental illness predicts intentions to seek care. The perspectives of mental health clinicians and patients on BPD have not been researched in the Pakistani setting and likely differ from other settings due to economic, cultural, and health care system differences. Our study aims to understand the attitudes of mental health clinicians towards patients with BPD in Pakistan using a self-report survey. We also aim to explore explanatory models of illness in individuals with BPD and their family members/carers using a Short Explanatory Model Interview (SEMI). The results of this study are important as we know attitudes and illness understanding greatly impact care. Results of this study will help guide BPD-specific training for mental health clinicians who care for patients with BPD and help inform approaches to interventions for patients with BPD in Pakistan.
Impact of the implementation of Identification-Situation-Background-Assessment-Recommendation (ISBAR) tool to improve quality and safety measure in a lithotripsy and endourological unit
Authors: Gadea-Company Patricia , Casal Angulo Carmen , Hurtado Navarro Clara
Published: June 2023

Introduction

A lack of professional communication and collaboration may be one of the main causes of medication errors. The objective was to evaluate the results of the implementation of ISBAR as a communication and safety tool in a Lithotripsy and Endourologic Unit of a tertiary public hospital.

Methods

A total of 457 patients were included in a retrospective study from 2014 to 2019. Patients were divided into two groups: group A (357 patients) in which an endourological procedure was performed before march of 2018 (without the implementation of ISBAR tool) and Group B (100 patients) with the implementation of ISBAR tool. The inclusion criteria were patients accepted for surgical intervention by anaesthesiology Department and operated in the period of the study. The variables analysed included number of procedures, global, intraoperative and postoperative complications rate, urinary infection or sepsis, NPR (FMEA), percentage of suspended surgical patients and hospital stay.

Results

The postoperative complications showed no significant differences between groups, but a trend to diminishing was seen in the complication in the group B. The sepsis reduced its incidence and it was close to significant difference. The operative time was shorter in group B 119,11min (114,63–123,59) vs 115,11min (109,63–121,67) p = 0,3. The reduction in the main postoperative complication (sepsis) explained the lower hospital stay for group B. The severe adverse events detected were reduced completely.

Conclusions

ISBAR tool was an effective patient safety tool improving quality care. To provide safe patient care and improving quality is indispensable an effective communication flow.
A new method for estimating growth and fertility rates using age-at-death ratios in small skeletal samples: The effect of mortality and stochastic variation
Authors: Galeta Patrik , Pankowská Anna
Published: June 2023

The common procedure for reconstructing growth and fertility rates from skeletal samples involves regressing a growth or fertility rate on the age-at-death ratio, an indicator that captures the proportion of children and juveniles in a skeletal sample. Current methods derive formulae for predicting growth and fertility rates in skeletal samples from modern reference populations with many deaths, although recent levels of mortality are not good proxies for prehistoric populations, and stochastic error may considerably affect the age distributions of deaths in small skeletal samples. This study addresses these issues and proposes a novel algorithm allowing a customized prediction formula to be produced for each target skeletal sample, which increases the accuracy of growth and fertility rate estimation. Every prediction equation is derived from a unique reference set of simulated skeletal samples that match the target skeletal sample in size and assumed mortality level of the population that the target skeletal sample represents. The mortality regimes of reference populations are based on model life tables in which life expectancy can be flexibly set between 18 and 80 years. Regression models provide a reliable prediction; the models explain 83–95% of total variance. Due to stochastic variation, the prediction error is large when the estimate is based on a small number of skeletons but decreases substantially with increasing sample size. The applicability of our approach is demonstrated by a comparison with baseline estimates, defined here as predictions based on the widely used Bocquet-Appel (2002, doi: 10.1086/342429) equation.
A pilot-scale comparison between single and double-digest RAD markers generated using GBS strategy in sesame (Sesamum indicum L.)
Authors: Ruperao Pradeep , Bajaj Prasad , Subramani Rajkumar , Yadav Rashmi , Reddy Lachagari Vijaya Bhaskar , Lekkala Sivarama Prasad , Rathore Abhishek , Archak Sunil , Angadi Ulavappa B. , Singh Rakesh , Singh Kuldeep , Mayes Sean , Rangan Parimalan
Published: June 2023

To reduce the genome sequence representation, restriction site-associated DNA sequencing (RAD-seq) protocols is being widely used either with single-digest or double-digest methods. In this study, we genotyped the sesame population (48 sample size) in a pilot scale to compare single and double-digest RAD-seq (sd and ddRAD-seq) methods. We analysed the resulting short-read data generated from both protocols and assessed their performance impacting the downstream analysis using various parameters. The distinct k-mer count and gene presence absence variation (PAV) showed a significant difference between the sesame samples studied. Additionally, the variant calling from both datasets (sdRAD-seq and ddRAD-seq) exhibits a significant difference between them. The combined variants from both datasets helped in identifying the most diverse samples and possible sub-groups in the sesame population. The most diverse samples identified from each analysis (k-mer, gene PAV, SNP count, Heterozygosity, NJ and PCA) can possibly be representative samples holding major diversity of the small sesame population used in this study. The best possible strategies with suggested inputs for modifications to utilize the RAD-seq strategy efficiently on a large dataset containing thousands of samples to be subjected to molecular analysis like diversity, population structure and core development studies were discussed.
Spatial and temporal activity patterns among sympatric tree-roosting bat species in an agriculturally dominated great plains landscape
Authors: Fill Christopher T. , Allen Craig R. , Benson John F. , Twidwell Dirac
Published: June 2023

In agroecosystems, bats can provide a critical ecosystem service by consuming night-flying insect pests. However, many bats also face intense population pressures from human landscape modification, global change and novel diseases. To better understand the behavioral activity of different bat species with respect to space, time, habitat, and other bat species in this environment, we investigated species correlations in space and time over row crop agricultural fields. We used acoustic grids to document spatial and temporal co-occurrence or avoidance between bats and recorded eight species across the 10 field sites we sampled. All species significantly overlapped in two-dimensional space and displayed considerable temporal overlap during the night, yet often exhibited significantly different temporal activity patterns, suggesting fine scale partitioning behavior. Conversion of land to agriculture is likely to increase globally, making it critical to better understand how bat species interact with one another and the landscape to facilitate persistence in these human altered ecosystems.
Excursions in the Bayesian treatment of model error
Authors: Berliner L. Mark , Herbei Radu , Wikle Christopher K. , Milliff Ralph F.
Published: June 2023

Advances in observational and computational assets have led to revolutions in the range and quality of results in many science and engineering settings. However, those advances have led to needs for new research in treating model errors and assessing their impacts. We consider two settings. The first involves physically-based statistical models that are sufficiently manageable to allow incorporation of a stochastic “model error process”. In the second case we consider large-scale models in which incorporation of a model error process and updating its distribution is impractical. Our suggestion is to treat dimension-reduced model output as if it is observational data, with a data model that incorporates a bias component to represent the impacts of model error. We believe that our suggestions are valuable quantitative, yet relatively simple, ways to extract useful information from models while including adjustment for model error. These ideas are illustrated and assessed using an application inspired by a classical oceanographic problem.
Single and co-inoculum of endophytic bacteria promote growth and yield of Jerusalem artichoke through upregulation of plant genes under drought stress
Authors: Boonmahome Patcha , Namwongsa Junthima , Vorasoot Nimitr , Jogloy Sanun , Riddech Nuntavan , Boonlue Sophon , Mongkolthanaruk Wiyada
Published: June 2023

Helianthus tuberosus L. (Jerusalem artichoke) produce inulin, a type of fructan, which possesses several biotechnology applications, e.g., sugar syrup, prebiotics, fiber in diabetic food, enabling blood sugar and cholesterol reduction. Drought reduces inulin accumulation in the tubers of Jerusalem artichoke as the plants protect themselves from this stress by induction of stress gene responses, effecting growth reduction. Endophytic bacteria are promising candidates to promote plant growth and yield particularly under abiotic stress. Therefore, three endophytic bacteria with plant growth promoting properties were examined for their ability to improve Jerusalem artichoke growth and yield under both well-watered and drought conditions when inoculated individually or in combinations in pot experiments with 2 factorial random complete block design. The interactions of the endophytic bacteria and plant host determined the differential gene expression in response to drought as revealed by quantitative polymerase chain reaction. Single inoculum of the endophytic bacteria increased the height, weight, root traits, and harvest index of Jerusalem artichoke compared to co-inocula under both well-watered and drought conditions. However, the co-inocula of Rossellomorea aquimaris strain 3.13 and Bacillus velezensis strain 5.18 proved to be a synergistic combination leading to high inulin accumulation; while the co-inocula of B. velezensis strain 5.18 and Micrococcus luteus strain 4.43 were not beneficial when used in combination. The genes, dehydrin like protein and ethylene responsive element binding factor, were upregulated in the plants inoculated with single inoculum and co-inocula of all endophytic bacteria during drought stress. Moreover, the gene expression of indole-3-acetic acid (IAA) amido synthetase were up-regulated in Jerusalem artichoke inoculated with M. luteus strain 4.43 during drought stress. The fructan:fructan 1-fructosyltransferase (1-FFT) was also stimulated by the endophytic bacteria particularly in drought condition; the results of this study could explain the relationship between endophytic bacteria and plant host for growth and yield promotion under well-watered and drought conditions.
Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
Authors: Kim Hyeonjin , Hur Jihyun K. , Kwon Mina , Kim Soyeon , Zoh Yoonseo , Ahn Woo-Young
Published: June 2023

Previous literature suggests that a balance between Pavlovian and instrumental decision-making systems is critical for optimal decision-making. Pavlovian bias (i.e., approach toward reward-predictive stimuli and avoid punishment-predictive stimuli) often contrasts with the instrumental response. Although recent neuroimaging studies have identified brain regions that may be related to Pavlovian bias, including the dorsolateral prefrontal cortex (dlPFC), it is unclear whether a causal relationship exists. Therefore, we investigated whether upregulation of the dlPFC using transcranial current direct stimulation (tDCS) would reduce Pavlovian bias. In this double-blind study, participants were assigned to the anodal or the sham group; they received stimulation over the right dlPFC for 3 successive days. On the last day, participants performed a reinforcement learning task known as the orthogonalized go/no-go task; this was used to assess each participant’s degree of Pavlovian bias in reward and punishment domains. We used computational modeling and hierarchical Bayesian analysis to estimate model parameters reflecting latent cognitive processes, including Pavlovian bias, go bias, and choice randomness. Several computational models were compared; the model with separate Pavlovian bias parameters for reward and punishment domains demonstrated the best model fit. When using a behavioral index of Pavlovian bias, the anodal group showed significantly lower Pavlovian bias in the punishment domain, but not in the reward domain, compared with the sham group. In addition, computational modeling showed that Pavlovian bias parameter in the punishment domain was lower in the anodal group than in the sham group, which is consistent with the behavioral findings. The anodal group also showed a lower go bias and choice randomness, compared with the sham group. These findings suggest that anodal tDCS may lead to behavioral suppression or change in Pavlovian bias in the punishment domain, which will help to improve comprehension of the causal neural mechanism.
Machine learning-based predictive model for prevention of metabolic syndrome
Authors: Shin Hyunseok , Shim Simon , Oh Sejong
Published: June 2023

Metabolic syndrome (MetS) is a chronic disease caused by obesity, high blood pressure, high blood sugar, and dyslipidemia and may lead to cardiovascular disease or type 2 diabetes. Therefore, the detection and prevention of MetS at an early stage are imperative. Individuals can detect MetS early and manage it effectively if they can easily monitor their health status in their daily lives. In this study, a predictive model for MetS was developed utilizing solely noninvasive information, thereby facilitating its practical application in real-world scenarios. The model’s construction deliberately excluded three features requiring blood testing, specifically those for triglycerides, blood sugar, and HDL cholesterol. We used a large-scale Korean health examination dataset (n = 70, 370; the prevalence of MetS = 13.6%) to develop the predictive model. To obtain informative features, we developed three novel synthetic features from four basic information: waist circumference, systolic and diastolic blood pressure, and gender. We tested several classification algorithms and confirmed that the decision tree model is the most appropriate for the practical prediction of MetS. The proposed model achieved good performance, with an AUC of 0.889, a recall of 0.855, and a specificity of 0.773. It uses only four base features, which results in simplicity and easy interpretability of the model. In addition, we performed calibrations on the prediction probability and calibrated the model. Therefore, the proposed model can provide MetS diagnosis and risk prediction results. We also proposed a MetS risk map such that individuals could easily determine whether they had metabolic syndrome.
Disruption of corporate financialization and labor cost growth: Evidence from China’s new asset management rules
Authors: Liu Chuyuan
Published: June 2023

The new asset management rules in China bring financial institutions under a unified regulatory framework, aiming to curb regulatory arbitrage, control systemic risk, and improve financial stability. Exploiting the new-rules-induced exogenous shock that disrupts corporate financialization, this study finds that firms with ex ante higher degrees of financialization respond to the regulation by increasing labor costs. Management’s financial expertise and ownership concentration are mechanisms through which disruption of financialization affects corporate employment strategies. The impact of the new rules on labor costs is more pronounced for firms with lower bankruptcy risk, located in coastal cities, and experiencing intense industry competition. The findings imply an unintended spillover effect of financial regulation on the labor market in the form of labor cost growth.
Early warning model and prevention of regional financial risk integrated into legal system
Authors: Zhuang Yanyu , Wei Hua
Published: June 2023

In order to improve the laws and regulations of the financial system, in the construction of laws and regulations, the traditional financial risk Early Warning (EW) model is optimized. The financial prevention and control measures with legal protection are implemented to warn the financial risks, which plays an important role in the construction of the rule of law in the Financial Market (FM) and the establishment of financial risk prevention and control laws and regulations. This paper combines the deep learning model and the Markov regime Switching Vector Auto Regression (MS-VAR) model and constructs a regional financial risk EW model from the following aspects: macroeconomic operation EW indicators, regional economic risk EW indicators, regional financial institution risk EW indicators. The model is empirically researched and analyzed. The results show that the fluctuation trend of the macroeconomic pressure index in the time series is relatively large, and the overall fluctuation of the regional economic pressure index is small, and fluctuates around 0 in most periods. After the financial crisis, local governments stepped up their supervision of non-performing corporate and household loans. From 2011 to 2018, the non-performing loan ratio began to decline, and the overall fluctuation of the regional financial comprehensive stress index was small, fluctuating around 0. Due to the lack of legal regulation, from the perspective of the regional economy, the risk level is more likely to change from low risk to moderate risk, while the risk status is less likely to change from high risk to moderate risk. From the perspective of regional financial institutions, the probabilities of maintaining low risk and moderate risk are 0.98 and 0.97, respectively, which is stronger than maintaining the stability of high risk. From the perspective of the state transition of the regional financial risk composite index, the probability of maintaining low risk and high risk is 0.97 and 0.93, which is higher than maintaining the stability of medium risk. The Deep Learning (DL) regional financial risk EW MS-VAR model has strong risk prediction ability. The model can better analyze the conversion probability of regional financial risk EW index and has better risk EW ability. This paper enhances the role of legal systems in financial risk prevention and control. The regional financial risk EW model incorporating financial legal indicators can better describe the regional financial risk level, and the EW results are basically consistent with the actual situation. In order to effectively prevent financial risks and ensure the safety of the financial system, it is recommended that the government improve local debt management, improve financial regulations and systems, and improve the legislative level of financial legal supervision.
OntoTrek: 3D visualization of application ontology class hierarchies
Authors: Dooley Damion , Nguyen Matthew H. , Hsiao William W. L.
Published: June 2023

An application ontology often reuses terms from other related, compatible ontologies. The extent of this interconnectedness is not readily apparent when browsing through larger textual presentations of term class hierarchies, be it Manchester text format OWL files or within an ontology editor like Protege. Users must either note ontology sources in term identifiers, or look at ontology import file term origins. Diagrammatically, this same information may be easier to perceive in 2 dimensional network or hierarchical graphs that visually code ontology term origins. However, humans, having stereoscopic vision and navigational acuity around colored and textured shapes, should benefit even more from a coherent 3-dimensional interactive visualization of ontology that takes advantage of perspective to offer both foreground focus on content and a stable background context. We present OntoTrek, a 3D ontology visualizer that enables ontology stakeholders—students, software developers, curation teams, and funders—to recognize the presence of imported terms and their domains, ultimately illustrating how projects can capture knowledge through a vocabulary of interwoven community-supported ontology resources.
Higher operating theatre temperature during burn surgery increases physiological heat strain, subjective workload, and fatigue of surgical staff
Authors: Palejwala Zehra , Wallman Karen E. , Maloney Shane , Landers Grant J. , Ecker Ullrich K. H. , Fear Mark W. , Wood Fiona M.
Published: June 2023

Raising the ambient temperature of the operating theatre is common practice during burn surgeries to maintain the patient’s core body temperature; however, the effects of operating in the heat on cognitive performance, manual dexterity, and perceived workload of surgical staff have not been assessed in a real-world context. Therefore, the aim was to assess the real-time impact of heat during burn surgeries on staff’s cognitive function, manual dexterity, and perceptual measures (workload, thermal sensation, thermal comfort, perceived exertion, and fatigue) and physiological parameters (core temperature, heart-rate, fluid loss, and dehydration). Ten burn surgery staff members were assessed in CON (24.0±1.1°C, 45±6% relative humidity [RH]) and HOT (30.8±1.6°C, 39±7% RH) burn surgeries (average 150 min duration). Cognitive performance, manual dexterity, and perceptual measures were recorded pre- and post-surgery, while physiological parameters were recorded throughout surgery. HOT conditions did not significantly affect manual dexterity or cognitive function (p > .05), however HOT resulted in heat strain (increased heart-rate, core temperature, and fluid loss: p < .05), and increased subjective workload, discomfort, perceived exertion, and fatigue compared to CON conditions (p < .05). Cognitive function and manual dexterity were maintained in hot conditions, suggesting that operating in approximately 31°C heat is a safe approach for patient treatment. However, job burnout, which is positively correlated with perceived workload, and the impact of cumulative fatigue on the mental health of surgery staff, must be considered in the context of supporting an effective health workforce.
The methylglyoxal pathway is a sink for glutathione in Salmonella experiencing oxidative stress
Authors: Kant Sashi , Liu Lin , Vazquez-Torres Andres
Published: June 2023

Salmonella suffer the cytotoxicity of reactive oxygen species generated by the phagocyte NADPH oxidase in the innate host response. Periplasmic superoxide dismutases, catalases and hydroperoxidases detoxify superoxide and hydrogen peroxide (H2O2) synthesized in the respiratory burst of phagocytic cells. Glutathione also helps Salmonella combat the phagocyte NADPH oxidase; however, the molecular mechanisms by which this low-molecular-weight thiol promotes resistance of Salmonella to oxidative stress are currently unknown. We report herein that Salmonella undergoing oxidative stress transcriptionally and functionally activate the methylglyoxal pathway that branches off from glycolysis. Activation of the methylglyoxal pathway consumes a substantial proportion of the glutathione reducing power in Salmonella following exposure to H2O2. The methylglyoxal pathway enables Salmonella to balance glucose utilization with aerobic respiratory outputs. Salmonella take advantage of the metabolic flexibility associated with the glutathione-consuming methylglyoxal pathway to resist reactive oxygen species generated by the enzymatic activity of the phagocyte NADPH oxidase in macrophages and mice. Taken together, glutathione fosters oxidative stress resistance in Salmonella against the antimicrobial actions of the phagocyte NADPH oxidase by promoting the methylglyoxal pathway, an offshoot metabolic adaptation of glycolysis.
PROVISIONAL COMPLIANCE WITH THE JUDGMENT HANDED DOWN IN ACTION OF REMOVAL OF FAMILY POWER
Authors: Rueda Junior Edson Jacobucci , Sebastião de Oliveira José
Published: June 2023

Objectives: The research aims to analyze the possibility of placing the child or adolescent welcomed in a surrogate family, in the case of an injunction that suspends the family power or a sentence not yet finalized that extinguishes that power. In order to reach this objective, the evolution through which the family institution has passed, the institution of provisional compliance with a decision or sentence, the suspension and extinction of family power, from the point of view of personality rights, especially familiar coexistence will be analyzed.
Methodology: Through the hypothetical-deductive method, with research in the doctrine and jurisprudence, it will be verified that the placement of the child or adolescent in a new familiar nucleus, when its legal situation has not yet been defined, effectively meets the right to family life and above all the principle of human dignity.
Results: It will be concluded that, in addition to not finding an obstacle in the technical procedural aspect, the measure is appropriate to combat the negative effects of institutional fostering, in addition to meeting the best interests of the child and adolescent, thus effecting the right to family life.
REVISITANDO O CONSTITUCIONALISMO ESTADUNIDENSE: O SENTIDO DA CLÁUSULA CONSTITUCIONAL DO IMPEACHMENT ONTEM E HOJE
Authors: Megali Neto Almir
Published: June 2023

Contextualização do tema: A Constituição de 1988 conferiu importantes funções ao Poder Judiciário, que, a partir disso, passou a influenciar e a interferir na atuação dos demais Poderes. A cidadania também instigou a população a ser mais ativa e participativa na gestão do Estado e dessa forma houve um apelo popular para a democratização de processos deliberativos que pudessem abrir espaço para participação da sociedade. Diante da frustração com a representatividade de políticos democraticamente eleitos, a sociedade viu no Poder Judiciário uma forma de fazer valer seus direitos, de influenciar e até intervir nos demais poderes.
Objetivos: O trabalho analisa a correlação entre a Judicialização da política e a democracia deliberativa no Brasil apontando alguns determinantes para a expansão da participação popular através do Poder Judiciário.
Metodologia: A metodologia utilizada foi a hipotético-dedutiva através da análises de fontes secundárias que tratam a judicialização da política e a democracia deliberativa de maneira geral e também de maneira específica no contexto brasileiro.
Resultados: Foi possível concluir que a Judicialização da política e democracia deliberativa no Brasil se correlacionam à medida em que a expansão do Poder Judiciário, através de suas incumbências e mecanismos constitucionais, influencia e até intervém na atuação política dos demais poderes, abrindo espaço para que a população tenha maior acesso a este Poder.
REFLEXÕES SOBRE O “CASO PINHEIRO” À LUZ DO ESTADO DE DIREITO SOCIOAMBIENTAL BRASILEIRO
Authors: Dantas Juliana Jota
Published: June 2023

Contextualização do tema: O “Caso Pinheiro” tem sua origem na atividade de mineração e extração da Salgema realizada pela empresa Braskem no Estado de Alagoas e representa atualmente um dos maiores desafios para efetivação dos ditames do Estado de Direito Socioambiental vigentes no Brasil diante da ameaça de colapso do solo em região de grande densidade urbana na capital alagoana.
Objetivos: Busca-se apresentar o caso alçado pelo “Observatório Nacional sobre Questões Ambientais, Econômicas e Sociais de alta Complexidade e Grande Impacto e Repercussão” ao holofote nacional e apreciar a interação de instituições públicas e privadas na realização de acordos homologados judicialmente para proteção das vítimas, coletividades afetadas e dos interesses difusos da sociedade, refletindo méritos e dificuldades encontradas na utilização de métodos alternativos para solução de macrolitígios.
Metodologia: Tendo em vista que o estudo do caso pode servir ao paradigma para prevenção de desastres utiliza-se do método indutivo e da pesquisa exploratória, no esteio doutrinário e normativo.
Resultados: O acompanhamento do Caso Pinheiro tem o legado de oferecer à função socioambiental elementos para sua concretização, apontando para deveres que recaem sobre a exploração de recursos naturais e da produção econômica pautadas nos princípios do Estado de Direito Socioambiental.
A RESPONSABILIDADE CIVIL DOS AGENTES NOTARIAIS E DE REGISTRO: ENTRE A TEORIA E A PRÁXIS APÓS A FIXAÇÃO DO TEMA 777 FEITO PELO SUPREMO TRIBUNAL FEDERAL
Authors: Cazzaro Kleber , Bley Santos Rodrigo , Andrade Aline Rodrigues de
Published: June 2023

Contextualização do tema: A Constituição de 1988 atribuiu natureza sui generis à atividade notarial e registral visto se tratar de serviço público exercido em caráter privado. A peculiaridade da disciplina é demonstrada pelos diversos entendimentos a respeito do regime, com reflexo consolidado pela doutrina e jurisprudência do Supremo Tribunal Federal (STF). Neste ensaio estão abordados os aspectos gerais da atividade notarial e registral, a responsabilidade civil dos agentes delegados e a jurisprudência atual sobre o tema.
Objetivos: A pesquisa visa analisar o reflexo da Tese de Repercussão Geral n. 777 do STF, que fixou o sistema de responsabilização civil dos notários e registradores, para o cenário da prática jurídica atual.
Metodologia: Segue-se o método dedutivo de abordagem para a construção do texto.
Resultados: Conclui-se que o Estado responde, objetivamente, pelos atos dos notários e registradores que, no exercício de suas funções, causem danos a terceiros, cabendo ao Estado o dever de regresso contra o responsável, nos casos de dolo ou culpa. Essa é a regra que deve ser respeitada e aplicada aos casos concretos que advierem para julgamento do Poder Judiciário.
A EFETIVIDADE NO DIREITO TRIBUTÁRIO E O RECURSO À TUTELA PENAL PARA A SATISFAÇÃO DOS INTERESSES FINANCEIROS: UMA PERSPECTIVA PRAGMÁTICA SOBRE A CARACTERIZAÇÃO DA APROPRIAÇÃO INDÉBITA TRIBUTÁRIA À LUZ DO RHC 163.334/SC
Authors: De Jesus Diógenes Teófilo , Campelo Roberto Lima
Published: June 2023

Contextualização: O presente artigo aborda o tema da tomada de decisão judicial no Brasil. A problemática nesse âmbito surge a partir da constatação da ineficiência da dogmática jurídica tradicional para propor subsídios satisfatórios para a crítica da jurisprudência por parte da doutrina.
Objetivo: O objetivo deste artigo é o de trazer ao leitor novas formas de análise da decisão judicial, além daqueles métodos de interpretação trazidas pela doutrina tradicional e sistematizada no Século XVIII. O método proposto é o pragmatismo jurídico, contextualizado no âmbito da efetividade do Direito Tributário e dos limites ao poder de tributar do Estado, a partir do recurso à tutela penal. Tudo, com destaque aos atributos pragmatistas, à teoria da decisão judicial, ao princípio constitucional da proporcionalidade e à subsidiariedade do Direito Penal. 
Metodologia: Por meio de pesquisa qualitativa e revisão bibliográfica, coleta e análises de dados em repositórios de decisões judiciais, investigamos o repertório jurídico enquanto fator limitante à incidência da tutela penal, nos termos do inciso II, do art. 2º, da Lei 8.137/90 e do RHC 166.334/SC, decisão paradigmática do Supremo Tribunal Federal que deu nova interpretação ao comando legal que tipifica o crime de apropriação tributária, com repercussão tanto no Direito Penal quanto no Direito Tributário.
Resultados: A partir da análise de uma decisão paradigmática do Supremo Tribunal Federal, é possível concluir que os métodos tradicionais da dogmática jurídica são insuficientes para abarcar a complexidade textual e contextual da decisão judicial. Nesse sentido, necessária uma nova abordagem da jurisprudência para seja possível traçar novas bases jurídicas para uma análise crítica de como decidem os tribunais brasileiros. O pragmatismo jurídico parece um método conglobante e apto a realizar esse objetivo.
STANDARDS, REGRAS E O MODELO DE NORMATIZAÇÃO DAS COMPRAS PÚBLICAS: CONTRADIÇÕES DA PROPOSTA MINIMALISTA
Authors: Gomes Lucas Thevenard
Published: June 2023

Contextualização: Tem-se tornado cada vez mais comum criticar o formalismo da atual legislação brasileira sobre licitações, denunciar o excesso de especificidade de algumas de suas regras e alegar que um regime baseado em princípios, mais aberto e flexível poderia resolver alguns dos mais evidentes problemas das compras públicas no Brasil. Essa linha de argumentação, chamada de “minimalismo”, trouxe um ponto de ênfase para o problema da especificidade normativa do regime licitatório brasileiro.
Objetivo: O objetivo deste artigo é oferecer críticas teóricas à proposta minimalista destacando a importância de dimensões institucionais das contratações públicas omitidas no debate atual.
Metodologia: Análise dedutiva a partir de conceitos da literatura acadêmica sobre desenho normativo.
Resultado: Apresentamos 3 objeções à chamada “proposta minimalista”, concluindo que falta ao atual debate uma compreensão mais robusta das dinâmicas socioeconômicas e institucionais que acompanham as decisões públicas.
AS DEMANDAS MULTITUDINÁRIAS NA ATUAL SOCIEDADE DO CONSUMO: NECESSIDADE DE PRECEDENTES JUDICIAIS DEMOCRÁTICOS
Authors: Gomes de Santana Neto Hamilton
Published: June 2023

Contextualização do tema: No atual cenário da sociedade do consumo, os conflitos sociais tendem a aumentar exponencialmente. Rente a isso, as demandas consumeristas expressam, no mundo jurídico, o sentimento de judicialização da vida moderna. Em paralelo às demandas em massa, têm-se decisões repetitivas, precedentes judiciais que, apesar de técnicos, muitas das vezes se preocupam na métrica de solver a relação processual, mas não o conflito social em si.
Objetivos: Assim, objetiva-se evidenciar a importância da formação de tais precedentes de maneira democrática como ideia a conferir maior participação dos setores sociais, moldando o precedente para além da contenda processual, preocupando-se, pois, com o real cenário dos conflitos humanos.
Metodologia: Para tanto, a pesquisa valeu-se do método dedutivo, através da exposição de dados oriundos de Instituições oficiais sobre o cenário fático para, a partir daí, viabilizar reflexões e análises lógico-jurídicas por meio de temas relacionados na doutrina e jurisprudência.
Resultados: Ao final, chega-se à reflexão de que a construção dos precedentes judiciais, neste atual cenário de demandas repetitivas, pode ocorrer de maneira dialógica entre o Poder Judiciário e as diversas Instituições públicas e privadas como mecanismo de conferir maior legitimidade ao entendimento fixado.
Concentration of solutions for
(
N
,
q
)
-Laplacian equation with Trudinger–Moser nonlinearity
Authors: Wang Li , Wang Jun , Zhang Binlin
Published: June 2023

In this article, we consider the concentration of positive solutions for the following equation with Trudinger–Moser nonlinearity:

{

−

Δ
N

u
−

Δ
q

u
+
V
(
ε
x
)
(

|

u

|

N
−
2

u
+

|

u

|

q
−
2

u
)
=
f
(
u
)
,

x
∈

R

N

,

u
∈

W

1
,
N

(

R

N

)
∩

W

1
,
q

(

R

N

)
,

x
∈

R

N

,

where
V
is a positive continuous function and has a local minimum,
ε
>
0
is a small parameter,
2
≤
N
<
q
<
+
∞
,
f
is

C
1

with subcritical growth. When
V
and
f
satisfy some appropriate assumptions, we construct the solution

u

ε

that concentrates around any given isolated local minimum of
V
by applying the penalization method for the above equation.
Qualitative analysis of a mechanical system of coupled nonlinear oscillators
Authors: Moroșanu Gheorghe , Vladimirescu Cristian
Published: June 2023

In this paper we investigate nonlinear systems of second order ODEs describing the dynamics of two coupled nonlinear oscillators of a mechanical system. We obtain, under certain assumptions, some stability results for the null solution. Also, we show that in the presence of a time-dependent external force, every solution starting from sufficiently small initial data and its derivative are bounded or go to zero as the time tends to
+
∞
, provided that suitable conditions are satisfied. Our theoretical results are illustrated with numerical simulations.
First insight of the response of great scallops (

Pecten maximus) to drilling activities during the construction phase of an Offshore Wind farm (Saint Brieuc, France)
Authors: Retailleau Elie , Mathias Delphine , Chauvaud Arthur , Richard Gaëtan
Published: June 2023

There are still major gaps in our knowledge of how invertebrates react to the sounds and vibrations generated by the construction of Offshore Wind Farms (OWFs). With the recent development of such projects in the vicinity of scallop (Pecten maximus) areas in France, particular attention has been paid to this economically important species. In this context, we monitored the activity of 30 scallops during drilling operations associated with the construction of the Saint Brieuc OWF. Equipped with valvometers (Hall effect sensors), the scallopswere deployed at three distances from a drilling point (300, 600, and 3000m) for three weeks, covering the platform vessel installation and the drilling operations. Two acoustic measurement buoys were also deployed (400 and 3000m) to assess the exposure of the scallops to drilling noise. The valve opening data acquired revealed a circadian cycle associated with nocturnal activity (more open at night than during the day) for the majority of individuals (82%). The individuals monitored maintained this cycle throughout the drilling period, regardless of distance from the drilling point. However, an increase in the number of large-amplitude movements was identified for scallops located 300m from the drill ship during its installation. Although the interpretation of this observation is tricky, it shows that scallops were able to perceive the installation of the jack-up vessel up to 3 km, with their response decreasing over thedistance. Further studies involving additional measurements (seismic, particle movement, etc.) are needed to better understand the effect of these activities on this species.
MCNET
Authors: Tiwari Ansh , Trankatwar Sachin
Published: June 2023

Deep learning has emerged as a powerful approach in various domains, including biological network analysis. This paper investigates the advancements in computational techniques for inferring gene regulatory networks (GRNs) and introduces MCNET, a state-of-the-art deep learning algorithm. MCNET integrates multi-omics data to infer GRNs and extract biologically significant representations from single-cell RNA sequencing (scRNA-seq) data. By incorporating attention mechanisms and graph convolutional networks, MCNET captures intricate regulatory relationships among genes. Extensive benchmarking on diverse scRNA-seq datasets demonstrates MCNET’s superiority over existing methods in GRN inference, scRNA-seq data visualization, clustering, and simulation. Notably, MCNET accurately predicts gene regulations on cell-type marker genes in the mouse cortex, validated by epigenetic data. The introduction of MCNET paves the way for advanced analysis of scRNA-seq data and provides a powerful tool for inferring GRNs in a multi-omics context. Moreover, this paper addresses the integration of multiomics data in gene regulatory network inference, proposing MCNET as a method that efficiently analyzes and visualizes homogeneous gene regulatory networks derived from diverse omics data. The inference capability of MCNET is evaluated through extensive experiments with simulation data and applied to analyze the biological network of psychiatric disorders using human brain data.
The Disinformation Wars
Authors: Sheehan Helena
Published: June 2023

Helena Sheehan turns her incisive eye on the so-called anti-disinformation industry, and wondering whether the mainstream media is using a newfound interest in fact-checking, fake news, and disinformation studies to conceal deeper biases, ones that occlude the hidden ideologies deceiving much of the public.
Atrioventricular Nodal Ablation Is Not an Effective Treatment Strategy in Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Asaki S. Yukiko , Kessler David , Nayak Aarushi , Kim Jeffrey J. , Miyake Christina Y.
Published: June 2023

Catecholaminergic polymorphic ventricular tachycardia is a rare but lethal heritable arrhythmia syndrome associated with both atrial and ventricular arrhythmias. Treatment includes antiarrhythmics, sympathetic denervation, and implantable cardioverter-defibrillators. The use of atrioventricular nodal ablation as a treatment strategy to prevent ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia was not found in the literature. This report describes a teenager with a presenting rhythm of atrial and ventricular fibrillation and cardiac arrest. Her clinical arrhythmia was predominantly atrial dysrhythmias, which delayed her diagnosis of catecholaminergic polymorphic ventricular tachycardia. Before her diagnosis, she underwent atrioventricular nodal ablation in an effort to prevent ventricular arrhythmias, which was ultimately ineffective. This report highlights the importance of recognizing atrial arrhythmias in catecholaminergic polymorphic ventricular tachycardia and provides evidence that atrioventricular nodal ablation is not an effective treatment strategy for this disease.
Um histórico do processo de institucionalização da participação no Brasil e suas implicações para as políticas educacionais
Authors: Assis Tauã Carvalho , Gohn Maria Glória
Published: June 2023

Neste trabalho, problematizamos a trajetória de institucionalização da participação sociopolítica no Brasil e seus efeitos e implicações para a educação e para o campo das políticas educacionais. Para isso, recorremos à literatura e periodizamos essa relação em cinco momentos, assim identificados por diferentes características e distintos resultados para a educação. Concluímos que a participação na educação é sempre tensionada por diferentes atores e cenários, que ora promovem um avanço da institucionalização da participação, ora induzem a um recuo desse princípio na definição das políticas educacionais. Aponta-se ainda a dificuldade de transposição das políticas de governo rumo às políticas de estado e a consequente fragilidade do estatuto da participação na condução dos assuntos educacionais.
La política de lo educativo en el “Reggio Emilia Approach” 75 años después: Diálogos sobre la belleza del espacio escolar con Vea Vecchi, Maddalena Tedeschi y Carlotta Ferrozzi
Authors: Márquez-Román Ana , Soto Gómez Encarnación
Published: June 2023

Hablar de las escuelas de Reggio Emilia es hablar de un proyecto educativo, político, ético y estético que continúa con plena vigencia más de medio siglo después de su nacimiento. Bajo una concepción del espacio como "tercer educador", este proyecto ha repensado desde sus inicios el diseño de lugares bellos y promotores de aprendizajes creativos, críticos y relevantes. ¿Qué principios sustentan el diseño de estos lugares?, ¿qué se entiende por un espacio bello?, ¿de qué manera la investigación sobre el espacio puede transformar la realidad cotidiana en las escuelas? Este artículo recoge el diálogo contrastado de tres pensadoras referentes en el “Reggio Emilia Approach”: Vea Vecchi, Maddalena Tedeschi y Carlotta Ferrozzi. Sus testimonios ayudan a comprender la relevancia de un proyecto educativo vinculado a la comunidad y a una imagen de infancia como ciudadanía, donde la calidad del espacio se define por la calidad de las relaciones que este permite y activa. Relaciones que se promueven desde la reflexión compartida entre docentes y otros profesionales a través de procesos de documentación pedagógica que, a su vez, estimulan el desarrollo profesional de maestras y maestros.
Leprosy Control
Authors: Richardus Jan Hendrik , Pahan David , Johnson Roch Christian , Smith W Cairns S
Published: June 2023

Leprosy Control
The Eye in Leprosy
Authors: Bairappagari Mary Esther John , Thompson Kirsteen J , Daniel Ebenezer
Published: June 2023

The Eye in Leprosy
Co-morbidities in Patients with Hansen's Disease
Authors: Gardiner Bradley J , Machado Paulo RL , Ooi Winnie W
Published: June 2023

Co-morbidities in Patients with Hansen's Disease
Rehabilitation & Social Aspects: Introductory Overview
Authors: Saunderson Paul
Published: June 2023

Rehabilitation & Social Aspects: Introductory Overview
Surgical Aspects in Leprosy
Authors: Virmond Marcos , Joshua Jerry , Solomon Samuel , Duerksen Frank
Published: June 2023

Surgical Aspects in Leprosy
The Physiology of Mycobacterium leprae
Authors: Brennan Patrick J , Spencer John Stewart
Published: June 2023

The Physiology of Mycobacterium leprae