bluuebunny/crossref_metadata_2025 huggingface dataset:
Classroom collaborations
Authors: Reeves Andrew
Published: October 2019

Purpose

This study aims to explore co-learning classes, a novel approach to leveraging universities’ capacity to contribute to the local sustainable development agenda whilst enhancing students’ learning. These participatory classes were piloted within a UK university masters’ module focussed on action for sustainability. The classes sought to combine knowledge exchange, reflection and social network development by bringing together students and community stakeholders.

Design/methodology/approach

The classes were run as a series of five free events, each focussed on sustainability issues relevant for local practitioners. These were either regular timetabled sessions opened up to the public or additional on-campus public events. Attendance was either face-to-face or online. Evaluation was based upon participation data, written feedback and module leader’s post-event reflections.

Findings

The classes successfully secured participation from diverse community members, including local government staff, voluntary sector workers and interested individuals. Both students and community stakeholders valued the participatory format, linkages of theoretical and practical knowledge and diversity of attendees.

Research limitations/implications

Findings are based upon a small-scale pilot study. Further research using a wider range of contexts is required to enhance understanding of the co-learning approach.

Practical implications

This paper highlights some key practical issues to consider if employing co-learning approaches in other contexts, including using inclusive language, aligning with students’ motivations and choosing appropriate focal event topics.

Originality/value

Opening up participatory university classes for the public to attend as co-learners is a rarely used approach and has little coverage in academic literature. This small-scale study therefore has value by highlighting some of the potential impacts, strengths and limitations of this approach.
The communicative processes of attempted political persuasion in social media environments
Authors: Kim Bumsoo , Barnidge Matthew , Kim Yonghwan
Published: October 2019

Purpose

The purpose of this paper is to investigate the process by which social media news use leads individuals to engage in attempted political persuasion, examining the mediating roles of cognitive elaboration, political knowledge, political efficacy and political interest.

Design/methodology/approach

The study relies on a nationally representative two-wave online survey collected before the 2016 US Presidential Election. Serial mediation is tested using the PROCESS macro.

Findings

The study finds significant indirect effects of social media news use on political persuasion via cognitive elaboration, political knowledge, political efficacy and political interest.

Research limitations/implications

Causal inferences should be made with caution. While the measurement of cognitive elaboration is based on prior literature, it is a complex mental process that could be measured more directly in future research.

Social implications

The findings imply that social media news use contributes to a potentially discursive environment in which cross-cutting views may drive argumentation. Thus, the study sheds light on how social media contribute to persuasive political conversation.

Originality/value

The study applies the O-S-R-O-R model to political persuasion and highlights the processes of reflection, understanding and elaboration that convert news use into attempted persuasion.
User-generated content (UGC) misclassification and its effects
Authors: Rajamma Rajasree K. , Paswan Audhesh , Spears Nancy
Published: October 2019

Purpose

User-generated content (UGC), e.g. YouTube videos on social media, is all around us. These UGCs are primarily demonstrational and/or informational in their execution format. However, viewers could easily misclassify the UGCs and that may be detrimental to the focal product in the UGC. This study aims to investigate this phenomenon.

Design/methodology/approach

The study uses an online survey (N= 459). The respondents were randomly exposed to one of the two UGCs – informational or demonstrational – and then responded to questions measuring their attribution and their purchase intention towards the focal product in the UGC.

Findings

Results indicate that about 20% of the respondents misclassified the type of UGC. Further, UGC characteristics such as vicarious experience, transparency and connectedness significantly enhance purchase intention, especially for demonstrational videos; demonstrational UGC, when correctly perceived yield the most favorable results; and misclassification does suppress these relationships.

Research limitations/implications

This study contributes to the theory and practice by linking the viewer evaluation of UGC on various evaluative dimensions (i.e. vicarious experience, connectedness, transparency and perceived risk), purchase intention towards the focal product in the UGC and correct or incorrect classification of the UGC format (demonstrational or informational). This study adds to the knowledge base about UGC by highlighting some of the pitfalls when viewers misclassify the UGC format and emphasizes the importance of a match between the content of the UGC and the perceptions and expectations associated with the medium on which it is uploaded. Like any other research, this study too has its limitations. It has only looked at a few possible variables that would predict the purchase intention in the context of the complex and rich phenomenon of UGC. Future studies should look at other sources of misclassification.

Practical implications

Given the ubiquitous nature of social media and their role in consumer decision-making, the findings of this study have serious practical implications. The results of the study highlight steps to be taken by both creators and marketers to improve effectiveness of UGCs.

Social implications

While this study does not focus on the social aspects of UGCs, it is not difficult to imagine the phenomenon of UGC misclassification, either as a mistake or deliberately induced and its social implications. Fake news seems to be not uncommon.

Originality/value

Even though the impact of consumer-to-consumer information exchange and UGC on consumers’ brand attitude and purchase intention is well recognized, there is limited research on this topic. Further, to the best of the authors’ knowledge, this study is the first to explicitly examine the concept of misclassification and corresponding issues in the context of UGCs.
Volatility dynamics of Malaysian listed property companies within the Asian public property markets by using a switching regime approach
Authors: Zekri Mohammad Muzzammil , Razali Muhammad Najib
Published: October 2019

Purpose

This paper aims to examine the dynamic of volatility of Malaysian listed property companies within pan-Asian public property markets based on different volatility perspective over the past 18 years, especially during the global financial crisis (GFC).

Design/methodology/approach

This study uses several statistical methods and formulas for analysing the dynamic of volatility of Malaysian listed property companies such as exponential generalised autoregressive conditional heteroscedasticity (EGARCH) and Markov-switching (MS) EGARCH. The MS-EGARCH model provides new insights on the volatility dynamics of Malaysian listed property companies compared to conventional volatility modelling techniques, particularly EGARCH. Additionally, this paper will analyse the volatility movement based on three different sub-periods such as pre-GFC, GFC and post-GFC.

Findings

The findings reveal that the markets perform differently under different volatility conditions. Moreover, the application of MS-EGARCH provides a different view on the volatility dynamics compared to the conventional EGARCH model, as MS-EGARCH provides more comprehensive findings, especially during extreme market conditions.

Originality/value

This study contributes to the literature on the dynamics of Malaysian listed property companies within pan-Asian countries, as the approach for assessing the volatility performance based on different volatility conditions is less explored by previous researchers.
Revisiting product classification to examine content marketing practices
Authors: Miliopoulou Georgia-Zozeta
Published: October 2019

Purpose

The purpose of this paper is to investigate how the degree of investment and involvement attributed to specific product categories, affect content marketing plans and practices on the Web and social media.

Design/methodology/approach

This is a conceptual paper based on the classification proposed by Morton and Devine (1985) on the axes of investment and involvement. The author uses secondary research evidence from both academic and industry sources to document content marketing trends in the US and the EU markets and allocates such trends using the semiotic square.

Findings

The findings indicate that products in each quadrant follow similar practices regarding content publishing, campaign planning and community management.

Research limitations/implications

Further research may test this model empirically and assess its merits in different markets.

Practical implications

Managers can use this model for content planning, considering category-related opportunities and limitations. The model may also serve as a teaching tool to familiarize students with older research and its potential contribution in current settings.

Originality/value

By applying an old model in the current US/EU context, this paper helps document and understand content marketing practices, paving the way toward their optimization.
Strength reduction factors for S355 to S500 steel grades under steady-state and transient-state heating
Authors: Hanus Francois , Caillet Nicolas , Gaillard Sylvain , Vassart Olivier
Published: October 2019

Purpose

This paper aims to describe coupon tests performed at elevated temperatures on S355 to S500 steel grades and comparison of test results with previous research studies and current EN 1993-1-2 material laws. The objective is to state if these steel grades satisfy to the current material laws and if the scope of application of these laws could be extended to S500 grades.

Design/methodology/approach

Two experimental programmes were launched to investigate the behaviour of S460M and S500M steel grades developed for hot-rolled sections. The first research programme was focussed on a comparison between S355 and S460 grades, where the second experimental programme was focussed on the recently developed S500M steel grade. The latter one comprised steady-state tests, transient-state tests and two large-scale beam tests.

Findings

Results of steady-state and transient-state tests correlate well with the reduction factors defined in EN 1993-1-2, currently limited to S460 grade. On the basis of this study, the scope of EN 1993-1-2 applies to S500 grades. For steady-state tests, the testing procedure (with and without acceleration after Rp0,2) led to noticeable differences. Transient-state tests, which are not standardised up to now, have been performed considering 5 K/min and 10 K/min constant heating rates. The slowest rate leads to lower strengths as creep effects are more significant. However, all the results are in line with EN 1993-1-2 material law. Importance should be given to the reference yield strength of steel at ambient temperature.

Originality/value

The revision of EN 1993-1-2 is on-going and this piece of work provides a contribution for extending the scope of application of material law of steel under fire conditions.
Understanding employee sabotage while serving refugees: the case of Syrian refugees in Turkey
Authors: Kabadayi Sertan
Published: October 2019

Purpose

Service providers can potentially play a critical role in responding to the global refugee crisis. However, recent evidence suggests that local service employees’ negative and inappropriate behavior is hindering efforts to alleviate the problems faced by refugees. As a response to the call to action to engage with the global refugee crisis in service context and adopting the transformative service research perspective, this paper aims to understand service employees’ motivations to engage in sabotage when they interact with refugees in service settings.

Design/methodology/approach

This paper focuses on the case of Syrian refugees in Turkey as a context. Using a netnographic study, this study analyzes comments by Turkish service employees in different social media groups and newspapers’ online platforms to reveal the motivations of those employees to engage in sabotage behavior.

Findings

The findings of this study revealed employees use five emerging themes as potential motivations to justify their sabotage behavior when serving refugees: perceived scarcity of resources, perceived fairness, perceived identity mismatch, perceived role of government and perceived role of other nations.

Research limitations/implications

The findings of this study have implications for service organizations, communities and governments to manage, change and even remove some of those perceptions that lead to employee sabotage resulting in increased suffering of refugees.

Originality/value

To the best of the author’s knowledge, this is the first study to examine the employee sabotage behavior in the context of serving refugees.
The quintuple helix innovation model and brain circulation in central, emerging and peripheral countries
Authors: De la Vega Hernández Iván Manuel , Barcellos de Paula Luciano
Published: October 2019

Purpose

The quintuple helix innovation model allows exploring the sustainable development of countries from the perspective of the capabilities that each of them possesses in terms of highly qualified personnel in science and technology. In addition, their distribution among the actors (helices) and the global mobility of this type of people are examined. The purpose of this paper is to dimension and characterise the research structures of the central, emerging and peripheral countries; to estimate the demand and mobility of scientists and technologists in the three selected countries; and to establish whether the concept of brain circulation applies to each of these types of countries.

Design/methodology/approach

The approach of the work is bibliometric and scientometric. In the first step, two theoretical frameworks were built. In the second step, indicators to measure the overall migration were developed and identified. In the third step, data from previous research were used, and data from Peru were added using the same methodology to be able to compare the three types of countries.

Findings

The study shows that the same terminology cannot be used globally to analyse the mobility of scientists in today’s world, despite technological advances because there is no critical mass in peripheral countries.

Originality/value

This study shows that the concept of brain circulation cannot be applied equally to all countries, because those that do not have critical mass lose capabilities, despite the existence of information and communication technologies.
Comparative analysis of range sensors for the robust autonomous navigation – a review
Authors: Singh Ravinder , Nagla Kuldeep Singh
Published: October 2019

Purpose

The purpose of this research is to provide the necessarily and resourceful information regarding range sensors to select the best fit sensor for robust autonomous navigation. Autonomous navigation is an emerging segment in the field of mobile robot in which the mobile robot navigates in the environment with high level of autonomy by lacking human interactions. Sensor-based perception is a prevailing aspect in the autonomous navigation of mobile robot along with localization and path planning. Various range sensors are used to get the efficient perception of the environment, but selecting the best-fit sensor to solve the navigation problem is still a vital assignment.

Design/methodology/approach

Autonomous navigation relies on the sensory information of various sensors, and each sensor relies on various operational parameters/characteristic for the reliable functioning. A simple strategy shown in this proposed study to select the best-fit sensor based on various parameters such as environment, 2 D/3D navigation, accuracy, speed, environmental conditions, etc. for the reliable autonomous navigation of a mobile robot.

Findings

This paper provides a comparative analysis for the diverse range sensors used in mobile robotics with respect to various aspects such as accuracy, computational load, 2D/3D navigation, environmental conditions, etc. to opt the best-fit sensors for achieving robust navigation of autonomous mobile robot.

Originality/value

This paper provides a straightforward platform for the researchers to select the best range sensor for the diverse robotics application.
BDNF‐TrkB pathway mediates antidepressant‐like roles of H2S in diabetic rats via promoting hippocampal autophagy
Authors: Liu Hai‐Yao , Wei Hai‐Jun , Wu Lin , Liu Su‐Mei , Tang Yi‐Yun , Zou Wei , Wang Chun‐Yan , Zhang Ping , Tang Xiao‐Qing
Published: October 2019

Hydrogen sulfide (H2S) plays antidepressant‐like roles in diabetic rats. However, the underlying mechanisms remain unclear. Brain‐derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high‐affinity tropomysin‐related kinase B (TrkB) receptor. Autophagy also is implicated in modulation of depression. Previous work confirmed the modulatory roles of H2S in BDNF protein expression and autophagy. Thus, in this study, we explored whether the BDNF‐TrkB pathway mediates the antidepressant‐like effects of H2S in diabetic rats and whether this process is achieved via promoting hippocampal autophagy. We demonstrated that H2S upregulated the expressions of BDNF and p‐TrkB proteins in the hippocampus of streptozotocin (STZ)‐induced diabetic rats. K252a (an inhibitor of BDNF‐TrkB pathway) reversed the antidepressant‐like roles of H2S, as evidenced by the tail suspension, forced swimming, novelty suppressed feeding, and elevated plus‐maze tests. Furthermore, K252a abolished H2S‐promoted hippocampal autophagy in diabetic rats, as evidenced by a decrease in the number of autolysosome, downregulation of Beclin‐1 (a regulator of autophagy in the early stage of the formation of autophagosomal membranes and its level is positively correlated with autophagic activity) expression, and upregulation of P62 (a substrate of autophagic degradation and its level is inversely correlated with autophagic activity) expression, in the hippocampus of rats co‐treated with NaHS and STZ. Taken together, these data indicated that the BDNF‐TrkB pathway mediates the antidepressant‐like roles of H2S in diabetic rats by enhancing hippocampal autophagy.
The controversy around the concept of archetypes
Authors: Hogenson George B.
Published: October 2019

The paper reviews the course of the controversy surrounding Jung's theory of archetypes beginning in the mid 1990s and continuing to the present. Much of this controversy was concerned with the debate between the essentialism of the evolutionary position of Anthony Stevens as found in his 1983 bookArchetypes: A Natural History of the Self, and the emergence model of the archetypes proposed in various publications by Hogenson, Knox and Merchant, among others. The paper then moves on to a consideration of more recent developments in theory, particularly as derived from an examination of the philosopher Gilles Deleuze, who introduces Bergson's somnambulistic unconscious into the discussion of Jung's theories. It is suggested that this largely unexamined influence on Jung may provide answers to some of the unanswered questions surrounding his theorizing. The paper concludes by suggesting that the notion of the somnambulistic unconscious may resemble Atmanspacher's argument for a dual‐aspect monism interpretation of Jung.
Comments on the 2018 IAAP Conference on Archetype Theory: defending a non‐reductive biological approach
Authors: Goodwyn Erik
Published: October 2019

During the course of the 2018 IAAP conference, a criticism of Jung’s idea of the archetype as inherited predisposition was raised that involved examining a number of dreams and visions and assessing them through developments in genetics and neuroscience. From this comparison it was argued that archetypes cannot be inherited and could more reasonably be argued to derive from early experiences. In this essay, the author responds by showing how this conclusion is flawed due to being based on reductive errors. An alternative, non‐reductive but inherited and biological position on the archetype is defended.
A dynamic systems approach to the feeling toned complex
Authors: Krieger Nancy M.
Published: October 2019

A review of Jung’s writing on the ‘feeling‐toned complex’ shows that he considered it to comprise independent, split‐off, psychic elements. Modern advances in scientific thinking and technology, namely Dynamic Systems Theory and neuro‐imaging, allow us to better define and explore this psychic phenomenon. Considering the constellation of the complex as a hierarchy of dynamic systems allows for a prediction of the timing of brain activity. This has been confirmed by two independent studies using fMRI and QEEG while administering the Word Association Experiment, the tool Jung used to investigate brain/psychic functioning over a century ago. Using as a framework the stages of the constellation of a complex viewed as a hierarchy of dynamic systems, I review the neuro‐imaging studies reported by Petchkovsky et al. (2013, 2017) and Escamilla et al. (2018), concluding that quantitative theoretical predictions and experimental results are in agreement within an order of magnitude. The change in attention caused by the constellation of the complex can also be conceived as the switching from a default neuro‐network, a startle response activating executive functioning in the frontal cortex of either the ego‐complex or an autonomous complex.
Basic needs and complexes: similarities between feeling‐toned complexes, emotional schema and affective states
Authors: Meier Isabelle
Published: October 2019

The aim of this paper is to examine feeling‐toned complexes from a developmental psychological perspective. From this perspective feeling‐toned complexes emerge when basic needs are not met. A very similar theory is put forward by Jeffery Young in his Schema Therapy (Young, Klosko, & Weishaar 2005). His basic needs concept, developed on the basis of empirical research, covers four basic needs which are: attachment, autonomy, and self‐worth, as well as play and spontaneity. My proposition is to deal with this conceptual view from a Jungian perspective insofar as we can integrate the four basic needs, however adding a fifth: the basic need for meaning in the theory of feeling‐toned complexes. Emotional schemas and feeling‐toned complexes are then comparable patterns. The strengths and weaknesses of Analytic Psychology compared to Jeffrey Young's schema therapy are further discussed. The foundation of the feeling‐toned complexes on unmet basic needs lends itself to including a further reference, namely Jaak Panksepp’s neuroscientific findings. Panksepp formulates seven basic affective systems which I discuss first, then I focus on what could be gained from the basic needs concept and finally I turn to the feeling‐complex in an attempt to integrate neuroscientific findings into complex theory.
Psychodynamic Psychotherapy Process Research: A quick ride through what you should know about process (research)
Authors: Buchholz Michael B.
Published: October 2019

This paper gives an overview of psychoanalytic process research, which brings to light the complexity of psychotherapy sessions. This complexity is so rich that many instruments intended to make the process measurable failed in the past because they initially used a strategy of complexity reduction. This method however did not help to further our understanding of the complexity involved. Three former presidents of the Society for Psychotherapy Research (Stiles, Hill, Elliot 2015) decided to solve the following equivalence paradox: many therapies work successfully though they all follow different theories, produce a heterogeneity of processes and often enough a misfit between what theories maintain to be a good process and their realization in the treatment room. As theories are often compared to maps, a driver would wonder which route to take. But therapists‐as‐drivers go undaunted ‐ and nevertheless achieve their goals together with their patients. Norcross and Wampold (2018) found that good therapists invent new therapies with every new patient. They hypothesize that it is because of conversation. This is in accord with the 3 former presidents’ proposal to return to detailed single case analyses including the micro‐analytic power of conversation analysis of which a few insights are outlined in this article.
Ambiguity and contradiction: the outlines of Jung’s dialectics
Authors: Pylkkö Pauli
Published: October 2019

This essay explores Jung’s thinking strategies, argumentation patterns, and concept formation processes, and reveals how they distinguish his work from normal present‐day science. Jung doesn’t much appreciate the law of noncontradiction, which is a cornerstone of classical logic, and he doesn’t refrain from using openly ambiguous theoretical terms. It will be pointed out that not only specific archetypes, but the notion of archetype itself, as well as other of Jung’s theoretical notions (energy, including libidinal energy, polarity, integration, wholeness, instinct, symbol, and so on), are consciously ambiguous and thus potentially contradictory. It is shown that this kind of dialectic research strategy and related contradiction‐tolerant and ambiguity‐tolerant methods connect his work to Post‐Kantian German Idealism, Schelling’s and Schopenhauer’s philosophy in particular. However, it was Hegel who, in his Science of Logic, presented a systematic overview of such dialectic principles of reasoning, which were, in the 19th century, widely applied by German philosophers, theologians, and other scholars. Unfortunately, Jung decided not to study Hegel, but, instead, wrote derogatorily of his work. It will be argued that a Jungian who wants to be conscious of her own argumentation strategies and methods of concept formation should study Hegel’s complex and sophisticated dialectical logic. In addition, it is suggested that Jungian depth psychology might help us to amend the phenomenological deficits of Hegel’s system by providing it with a primal experiential source. This is needed because Hegel’s Geist, due to its intellectual emphasis, is a self‐conscious conceptual totality which advances progressively from stage to stage by guiding itself with the help of dialectical reason (Vernunft). It will be shown that if enriched with a proper kind of experiential givenness, which includes the Jungian unconsciousness (with libidinal energy, instincts, and archetypes), Hegelian metaphysics would be able to embrace a seriously aconceptual or preconceptual dimension. Aconceptual experience, which is, for Jung, mainly the instinctual layer of archetypes, remains essentially inaccessible, not only for normal scientific concepts, but for the concepts of any form of dialectics as well.
How Can I Manage Thrombocytopenia in Hemodialysis Patient? A Review
Authors: Guo Qiaoyan , Lou Yan , Liu Lihua , Luo Ping
Published: October 2019

Hemodialysis (HD) is the most important treatment for patients with end‐stage renal disease (ESRD). Thrombocytopenia is a potential treatment complication related to dialysis. Under normal circumstances, the platelet count would slightly decrease within the first hour of HD, but get restored towards the end of procedure. In most patients, the platelet count can be maintained within the normal range, and the occurrence of thrombocytopenia is relatively rare in clinical practice. Therefore, the possibility of thrombocytopenia in HD patients is often ignored. Moreover, thrombocytopenia might be misdiagnosed and mistreated. At present, almost all articles on the subject, apart from some case reports, focus on pseudothrombocytopenia and heparin‐induced thrombocytopenia. In this review, we summarized various underlying causes, mechanisms, and diagnostic approaches to thrombocytopenia in HD patients. The review aims to provide a guide for clinicians interested in the causes and adequate treatment of thrombocytopenia.
Comparative advantage and agricultural trade
Authors: Donaldson Dave
Published: October 2019

This article is based on a transcript of the Leonard K. Elmhirst Memorial Address, delivered at the 30th International Conference of Agricultural Economists in Vancouver, Canada, on July 29, 2018. The presentation provided an overview of work that I have done recently on comparative advantage and its role in agricultural trade patterns and trade‐driven changes in welfare. Two topics are addressed: (a) the static gains from intranational agricultural trade due to comparative advantage; and (b) how trade might mitigate consumption losses and food insecurity from changes in agricultural productivity caused by drought and climate change.
Can improved agricultural technologies spur a green revolution in Africa? A multicountry analysis of seed and fertilizer delivery systems
Authors: Ariga Joshua , Mabaya Edward , Waithaka Michael , Wanzala‐Mlobela Maria
Published: October 2019

Sub‐Saharan Africa faces low agricultural productivity amid a confluence of trends that include rapid population growth, climate change, and the rise of the middle class. To raise productivity, governments—in partnership with donors and development organizations—have launched numerous initiatives to encourage the development of sustainable and competitive agricultural input markets. Despite these efforts, markets remain underdeveloped in most countries and access to affordable seeds and fertilizers remains a major challenge for smallholder farmers. This paper explores evidence from recent multicountry analyses of input delivery systems to assess the possibility of a Green Revolution in Africa. It describes use and adoption levels, challenges, policy and regulatory issues, and investments needed to expand smallholder access to these productivity‐enhancing agricultural technologies.
Inflammatory bowel disease: estimates from the global burden of disease 2017 study
Authors: Piovani Daniele , Danese Silvio , Peyrin‐Biroulet Laurent , Bonovas Stefanos
Published: October 2019

Background

Inflammatory bowel disease (IBD) is a significant health problem in the industrialised world, currently increasing in developing countries. Understanding the global burden of IBD is important to tackle increasing disease occurrence.

Aim

To investigate the GBD (Global Burden of Disease) 2017 Study Database summarising and critically evaluating the global burden of IBD

Methods

We presented age‐standardised prevalence estimates, disability‐adjusted life years (DALYs) and its components: years lived with disability (YLDs) and years of life lost (YLLs) due to premature mortality. We reported these measures from 1990 to 2017 and stratified by region, socio‐demographic index (SDI), gender and age group.

Results

The latest IBD prevalence and burden estimates varied widely across regions, and were particularly elevated in high‐SDI countries. Despite an increasing prevalence from 1990 to 2017 (+6%), the IBD burden decreased (DALYs −12%). This decrease was driven by IBD‐associated premature mortality (YLLs −26%). This measure represented a high share of disease burden in low‐SDI countries (86% of DALYs), whereas disability constituted the predominant component in high‐SDI countries (71%) in 2017. Disease burden decreased particularly in children (DALYs −39% and YLLs −52%). In the last 10 years, however, prevalence plateaued in middle‐ to high‐SDI countries and steeply increased in low‐SDI countries.

Conclusions

These findings highlight significant improvements in IBD care in the last three decades, particularly in children. The global burden of IBD and premature mortality have progressively decreased. The increase in disease frequency observed in developing countries is worrying, especially considering the high associated premature mortality in these areas.
Spatiality, belonging and citizenship in the age of migration in contemporary China
Authors: Kochan Dror
Published: October 2019

While internal migration in contemporary China ascribes a great change to urban China's demographic composition, social structures and economic development trajectories, it is yet to restructure the formal definitions of urban identity and belonging, which are still dominated by the household registration system (hukou). The paper suggests that as a result of changes in the political, economic, demographic and social contexts within which China's internal migration develops, there emerge a crucial need to re‐examine the crude forms of determining identity and belonging, questioning the addressing of spatiality within the existing mechanisms (such as hukou system or the shiminhua discourse). To do so, the paper argues that the existing de‐territorialisation of the migration experience has to be replaced with a more nuanced understanding of how spatial practices and conceptualisations shape migrants’ experiences, as it is becoming imperative to develop a new framework that is more sensitive to migrants’ lived process of identification and belonging, especially as these traverse multiple geographies and spatial scales. This close engagement with migrants’ spatiality can then be used as a base from which to engage with a more complex view of migrants’ spatial and social relatedness, as well as the development of their urban belonging and identity.
Genetic insight into cytochrome P450 in Chinese from the Chinese Millionome Database
Authors: Qi Guangzhao , Han Chao , Sun Ya , Zhou Yubing
Published: October 2019

Genetic variations of cytochrome P450 (CYP) influence the inter‐individual differences in drug response. Here, we collected 8682 variants of 57 CYP genes and cytochrome P450 oxidoreductase (POR) from a large‐scale sequencing project in Chinese, Chinese Millionome Database (CMDB). In addition, 52 294 variants from the Genome Aggregation Database (gnomAD) had been simultaneously identified and analysed. Rare variants with a variant allele frequency (VAF) < 0.01 comprised 41.4% (3594/8682) of identified variations in the CMDB, while 98.1% (51 320/52 294) in the gnomAD were rare. Out of 8682 variants in the CMDB, 66.9% (5808/8682) were in introns and only 4.3% (377/8682) were missense variants. In contrast, 36.2% (18 929/52 294) variants in the gnomAD were missense. The common alleles with a VAF over 0.1 were found in CYP1A2*1C, CYP1A2*1F, CYP2C19*2, CYP2D6*2, CYP2D6*10, CYP3A5*3 and CYP4F2*3, with a VAF of 0.161, 0.6, 0.27, 0.274, 0.678, 0.92 and 0.233, respectively. The growing number of genetic variations in CYP genes as more genomes are sequenced would increase the power to predict drug metabolism and response based on the genotype of the particular individual.
Weakening and eastward shift of the tropical Pacific Walker circulation during the Last Glacial Maximum
Authors: Tian Zhiping , Jiang Dabang
Published: October 2019

The annual and seasonal changes in the tropical Pacific Walker circulation (PWC) during the Last Glacial Maximum (LGM) are investigated using all available numerical experiments from the Paleoclimate Modelling Intercomparison Project Phases 2 and 3. Compared to the preindustrial period, the annual mean of the PWC intensity weakened by an average of 0.96×1014 kg2 m−2 s−1 or 15%, and both the western edge and centre of the PWC cell shifted eastward by an average of 9° and 8°, respectively, as obtained from the ensemble mean of the 16 models used for analysis during the LGM. Those changes were closely linked with an overall weakening of the equatorial Indo‐Pacific east–west sea‐level pressure difference and low‐level trade winds over the equatorial west/central Pacific. On the seasonal scale, the LGM PWC generally weakened and shifted eastward throughout the seasons of year. In response to the LGM's large ice sheets and lower atmospheric greenhouse gas concentrations, large‐scale uneven surface cooling in the Northern Hemisphere led to an increased (a decreased) land–sea thermal contrast in boreal cold (warm) seasons. These induced decreases in the North Asian and African monsoon rainfall and hence suppressed a large‐scale thermally direct east–west circulation in the two seasons. As a result, the LGM PWC weakened and shifted eastward in both boreal cold and warm seasons, which jointly contributed to the weakening and eastward shift of the annual mean PWC.
Nutraceuticals as modulators of gut microbiota: Role in therapy
Authors: Quigley Eamonn M.M.
Published: October 2019

As our knowledge of the various roles of the gut microbiota in the maintenance of homeostasis grows and as we learn how a disrupted microbiota may contribute to disease, therapeutic strategies that target our microbial fellow‐travellers become ever more attractive. Most appealing are those interventions that seek to modify or supplement our diet through the addition of nutraceuticals. We now know that our diet, whether in the short or long term, is a major modifier of microbiota composition and function. Of the various nutraceuticals, two categories, prebiotics and probiotics, have received the greatest attention in basic research and product development. While our understanding of the impacts of prebiotics and probiotics on the indigenous microbiota and host biology have been described in great detail in vitro and in animal models, the clinical literature leaves much to be desired. While many claims have been made, few are supported by high quality clinical trials.

Linked Articles

This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
Fungal evolution: diversity, taxonomy and phylogeny of the Fungi
Authors: Naranjo‐Ortiz Miguel A. , Gabaldón Toni
Published: October 2019

The fungal kingdom comprises a hyperdiverse clade of heterotrophic eukaryotes characterized by the presence of a chitinous cell wall, the loss of phagotrophic capabilities and cell organizations that range from completely unicellular monopolar organisms to highly complex syncitial filaments that may form macroscopic structures. Fungi emerged as a ‘Third Kingdom’, embracing organisms that were outside the classical dichotomy of animals versus vegetals. The taxonomy of this group has a turbulent history that is only now starting to be settled with the advent of genomics and phylogenomics. We here review the current status of the phylogeny and taxonomy of fungi, providing an overview of the main defined groups. Based on current knowledge, nine phylum‐level clades can be defined: Opisthosporidia, Chytridiomycota, Neocallimastigomycota, Blastocladiomycota, Zoopagomycota, Mucoromycota, Glomeromycota, Basidiomycota and Ascomycota. For each group, we discuss their main traits and their diversity, focusing on the evolutionary relationships among the main fungal clades. We also explore the diversity and phylogeny of several groups of uncertain affinities and the main phylogenetic and taxonomical controversies and hypotheses in the field.
Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer
Authors: Imaizumi Ken , Suzuki Toshihiro , Kojima Motohiro , Shimomura Manami , Sakuyama Naoki , Tsukada Yuichiro , Sasaki Takeshi , Nishizawa Yuji , Taketomi Akinobu , Ito Masaaki , Nakatsura Tetsuya
Published: October 2019

Chemoradiotherapy (CRT) is the standard neoadjuvant therapy for locally advanced rectal cancer (RC). However, neoadjuvant chemotherapy (NAC) also shows favorable outcomes. Although the immunological environment of RC has been thoroughly discussed, the effect of NAC on it is less clear. Here, we investigated the immunological microenvironment, including T cell infiltration, activation, and topological distribution, of resected RC tissue after neoadjuvant therapies and evaluated the correlation between T cell subsets and patient prognosis. Rectal cancer patients (n = 188) were enrolled and categorized into 3 groups, namely CRT (n = 41), NAC (n = 46), and control (surgery alone; n = 101) groups. Characterization of residual carcinoma cells and T cell subsets in resected tissues was performed using multiplex fluorescence immunohistochemistry. The densities of total and activated (Ki67high) T cells in tissues after NAC, but not CRT, were higher than in control. In both CRT and NAC groups, patients presenting with higher treatment effects showed aggressive infiltration of T cell subsets into carcinomas. Multivariate analyses of pathological and immunological features and prognosis revealed that carcinoma Ki67highCD4+ T cells after CRT and stromal Ki67highCD8+ T cells after NAC are important prognostic factors, respectively. Our results suggest that evaluation of T cell activation with Ki67 expression and its tumor localization can be used to determine the prognosis of advanced RC after neoadjuvant therapies.
Sleep Facilitates Coping: Moderated Mediation of Daily Sleep, Ethnic/Racial Discrimination, Stress Responses, and Adolescent Well‐Being
Authors: Wang Yijie , Yip Tiffany
Published: October 2019

Using a daily diary design and actigraphy sleep data across 2 weeks among 256 ethnic/racial minority adolescents (Mage = 14.72; 40% Asian, 22% Black, 38% Latinx; 2,607 days), this study investigated how previous‐night sleep (duration, quality) moderated the same‐day associations between ethnic/racial discrimination and stress responses (rumination, problem solving, family/peer support seeking) to predict daily well‐being (mood, somatic symptoms, life satisfaction). On days when adolescents experienced greater discrimination, if they slept longer and better the previous night, adolescents engaged in greater active coping (problem solving, peer support seeking), and subsequently had better well‐being. Adolescents also ruminated less when they slept longer the previous night regardless of discrimination. Findings highlight the role of sleep in helping adolescents navigate discrimination by facilitating coping processes.
A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild‐to‐moderate asthma
Authors: Ortega Hector , Fitzgerald Mary , Raghupathi Kartik , Tompkins Cindy‐ann , Shen Jinshan , Dittrich Karen , Pattwell Caroline , Singh Dave
Published: October 2019

Background

GB001 is an oral antagonist of the prostaglandin D2 receptor that may inhibit recruitment and activation of airway eosinophils, reducing airway inflammation.

Objective

To assess GB001 safety, efficacy and pharmacokinetics from a Phase 2 study and explore the association between type 2 biomarkers (fractional exhaled nitric oxide and blood eosinophils) and asthma control markers following GB001 administration.

Methods

A randomized, placebo‐controlled, double‐blind study evaluating 36 patients with mild‐to‐moderate atopic asthma. Patients receiving fluticasone propionate ≤500 mcg/day or equivalent were randomized (2:1) to GB001 (30 mg) or placebo once daily for 28 days. Safety, pharmacokinetics, forced expiratory volume in 1 second, asthma control questionnaire and rescue medication use were assessed. Clinical outcomes were analysed post hoc by baseline fractional exhaled nitric oxide (<35 and ≥35 ppb) and blood eosinophil (<250 and ≥250 cells/µL) subgroups.

Results

GB001 was well tolerated and rapidly absorbed with a 14.5‐hour terminal half‐life. Overall, GB001 demonstrated greater improvement relative to placebo in forced expiratory volume in 1 second at Day 28 (102 mL [95% CI: −110, 314]). Greater effects on forced expiratory volume in 1 second were observed in the high baseline fractional exhaled nitric oxide and blood eosinophil subgroups (207 mL [95% CI: −283, 698];133 mL [95% CI: −422, 687], respectively). These effects were observed as early as Day 2 (229 mL [95% CI: −170, 628]; 163 mL [95% CI: −223, 550] for the high baseline fractional exhaled nitric oxide and blood eosinophil subgroups, respectively) and were sustained through treatment completion.

Conclusion and clinical relevance

GB001 was well tolerated, with the estimated half‐life supporting once‐daily (QD) dosing. GB001 may have a rapid and sustained effect on lung function, particularly in patients with type 2 phenotype. Further studies are needed to confirm these findings.
Neutrophil proteases degrade autoepitopes of NET-associated proteins
Authors: de Bont C M , Eerden N , Boelens W C , Pruijn G J M
Published: October 2019

Neutrophils can form neutrophil extracellular traps (NETs) to capture microbes and facilitate their clearance. NETs consist of decondensed chromatin decorated with anti-microbial proteins. Here, we describe the effect of neutrophil proteases on the protein content of NETs. We show that the neutrophil serine proteases degrade several neutrophil proteins associated with NETs. Interestingly, the anti-bacterial proteins associated with NETs, such as myeloperoxidase, calgranulin B and neutrophil elastase (NE), seem to be less susceptible to proteolytic degradation than other NET proteins, such as actin and MNDA. NETs have been proposed to play a role in autoimmune reactions. Our data demonstrate that a large number of the autoepitopes of NET proteins that are recognized by autoantibodies produced by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients are also removed by the proteases. In conclusion, neutrophil serine proteases have a major impact on the NET proteome and the proteolytic changes of NET-associated proteins may counteract autoimmune reactions to NET components.
Mothering and everyday life during and in the aftermath of domestic violence among women with immigrant backgrounds in Norway
Authors: Hauge Mona‐Iren , Kiamanesh Parvin
Published: October 2019

This paper focuses on how immigrant women experience and negotiate their everyday life with children prior to and after leaving a violent partner. Twenty‐three women staying at domestic violence and abuse shelters with their children were interviewed about their experiences with assistance services and their everyday life with their children. At the time of the interviews, most of the women were legally separated or divorced and were either living in or in touch daily with shelters. In this paper, we look at some of the challenges that women face when exposed to violence in a relationship that involves children. Being exposed to violence from a partner raises a number of economic, practical, and emotional concerns, both prior to and after leaving. For the mothers in our study, maintaining a regular routine is key to making the children feel safe in an unpredictable setting. For many, economic dependence on the partner is replaced with economic dependence on assistance services after leaving the partner. Services must recognize that providing help to mothers who have left a violent partner constitutes more than just practical support but is crucial for mothers' ability to re‐establish a predictable everyday life with their children.