bluuebunny/crossref_metadata_2025 huggingface dataset:
AGRICULTURA DIGITAL E A SUSTENTABILIDADE NO CAMPO: STATUS ATUAL E TENDÊNCIAS
Authors: Da Silva Júnior Afonso Henrique , Leal Tarcísio Wolff , Müller Júlia de Oliveira Martins , De Oliveira Carlos Rafael Silva , De Oliveira Patrícia Viera
Published: October 2024

A produção sustentável de alimentos e a digitalização do campo estão cada vez mais interligadas, no qual a tecnologia vem desempenhando um papel importante na busca por sistemas agrícolas mais eficientes e ambientalmente responsáveis. A produção sustentável de alimentos se refere a práticas agrícolas que minimizam os impactos negativos ao meio ambiente, promovem o equilíbrio e a manutenção do solo e preservam os recursos naturais. Neste sentido, a digitalização do campo desempenha um papel crucial. Nos últimos anos, a aplicação de tecnologias avançadas no campo está se tornando recorrente, por exemplo, o uso de drones e de sensores. A presença de tecnologia avançada na lavoura vem possibilitando a coleta de dados mais precisa e em tempo real sobre o solo, as plantas, as condições climáticas e outras variáveis relevantes. Essas informações possibilitam ao agricultor uma tomada de decisão mais assertiva e estratégica em relação ao manejo das culturas. Diante desse cenário, o objetivo deste trabalho de revisão foi abordar a relação entre a produção sustentável de alimentos e a transformação digital no campo, discutindo os benefícios, os desafios, as tendências e os exemplos de tecnologias inovadoras que estão revolucionando o campo. Além disso, pesquisas relevantes dos últimos anos sobre a produção sustentável de alimentos e a aplicação de tecnologias na agricultura foram apresentadas. Para o desenvolvimento deste artigo de revisão foram realizadas buscas nas principais bases científicas utilizando inúmeras palavras-chave (Produção Sustentável de Alimentos; Transformação Digital no Campo; Tecnologias Habilitadoras; Inteligência Artificial, Big Data Aplicado na Lavoura; Agricultura Sustentável; Agricultura Orgânica; Eficiência na Produção de Alimentos; Agricultura 4.0; e Agroflorestas).
Exploring Oral Immunotherapeutics in Oncology: Uses, Side Effects Novel Approaches, Challenges, and Future Prospects
Authors: Sandhu Kalya Ahmad , Yameen Asawar , Zafar Naima , Ali Hira , Abid Usama , Raza Mishkaat
Published: October 2024

Immunotherapy is a medical intervention in which certain immune system components are used to combat disease. Usually, immunotherapy works by helping the body fight off the offending substance by modifying it as well as boosting the immune system. Biologic therapy or biotherapy are additional terms for certain forms of immunotherapy. Different advances and novel approaches have been studied such as cancer vaccines, immune checkpoint inhibitors, monoclonal antibodies, etc. Oral immunotherapeutics are used in a variety of solid tumors and hematological malignancies but still, these immunotherapeutics have their own limitations and adverse effects. Management of these side effects and optimization of therapeutic benefits remains a challenge. Moreover, challenges such as patient selection, dose optimization, and medication resistance are major issues that hinder the widespread use of oral immunotherapeutics. However, the future of oral immunotherapy in oncology seems to be promising due to the new advancements and research done. New advancements hold the potential to revolutionize cancer therapy.
Pregled stočarske proizvodnje i aktualnih mjera poljoprivredne politike
Authors: Mikuš Ornella , Kovačićek Tihana , Jež Rogelj Mateja
Published: October 2024

Der kroatische Viehzuchtsektor ist durch ein niedriges Produktivitätsniveau und mangelnde Wettbewerbsfähigkeit gekennzeichnet. Darüber hinaus wurde nach dem EU-Beitritt Kroatiens die Zahl der Sauen um 30 % reduziert, was sich auf den Rückgang der Schweinefleischproduktion auswirkte. Auch die Rindfleischproduktion ging um rund 10 % zurück. Der größte Produktionsrückgang wurde in der Milchviehzucht verzeichnet, was sich in einem starken Rückgang der Zahl der Milchkühe um 35 % gegenüber dem Jahr 2012, also vor dem EU-Beitritt, widerspiegelt. In dem Viehzuchtsektor wurde nur bei der Geflügelfleischproduktion ein Wachstum und bei der Eierproduktion Stabilität verzeichnet. Ab 2020 wird der Viehzuchtsektor durch die COVID-19-Krankheit und den Krieg in der Ukraine mit einer hohen Inputpreisinflation konfrontiert. Ab 2023 kommt als weiteres Problem die Afrikanische Schweinepest hinzu, die den Handel mit lebenden Tieren und Fleisch beeinträchtigt. Die Produktion von Schafen und Ziegen hat in den letzten zehn Jahren zugenommen und ist in erster Linie eine zusätzliche Einnahmequelle für die Wirtschaft. Kroatien produziert nicht genügend tierische Erzeugnisse für seinen Bedarf und gleicht dies durch den Import von lebenden Tieren, Fleisch und Milch aus. Die Produkte, die wir exportieren, werden in der Regel in Form von Rohstoffen ohne Wertschöpfung ausgeführt, während wir komplexere und teurere Produkte importieren. Der größte Teil der Produktion in der Viehwirtschaft ist in hohem Maße von öffentlichen Einkommenssubventionen abhängig, die nicht zu Verbesserungen in diesem Sektor führen. Die Agrarpolitik im Zeitraum 2023-2027 ist bestrebt, die wirtschaftlichen, sozialen, ökologischen und klimatischen Probleme des Sektors auf nachhaltige Weise zu lösen. Ziel dieser Arbeit ist es, die Situation des Viehzuchtsektors auf der Grundlage der wichtigsten statistischen Indikatoren von 2013 bis 2022 zu beschreiben und agrarpolitische Maßnahmen zur Verbesserung des Sektors vorzustellen.
Mikrobiološke opasnosti u proizvodnji spontano fermentiranih kobasica od mesa divljači
Authors: Mrkonjić Fuka Mirna , Odorčić Valentina , Maslov Bandić Luna , Tanuwidjaja Irina
Published: October 2024

Tradicionalne, spontano fermentirane kobasice od mesa divljači zauzimaju važno mjesto u gastronomiji različitih kultura i naroda u Europi i svijetu. U Republici Hrvatskoj proizvode se na brojnim malim obiteljskim gospodarstvima, prateći tradicionalne recepture i postupke, te su prepoznate i cijenjene kao visoko kvalitetan proizvod specifičnih senzornih osobina. Međutim, budući da se proizvode bez upotrebe starter kultura i često u varijabilnim uvjetima proizvodnje (temperatura i vlaga), mikrobiološka ispravnost krajnjeg proizvoda može biti kompromitirana, čemu značajno doprinose i faktori povezani s načinom odstrijela životinja i obrade mesa. Mikrobiološke opasnosti povezane s proizvodnjom tradicionalnih, spontano fermentiranih kobasica od mesa divljači uključuju različite patogene mikroorganizme poput Enterobacteriaceae, Escherichia coli, Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, Clostridium botulinum i drugi, te toksične produkte njihovog metabolizma poput biogenih amina i mikotoksina. Standardizacija proizvodnje i upotreba visokokvalitetnih sirovina ključni su za dobivanje zdravstveno ispravnog proizvoda ujednačenih svojstava. Uz to, iznimno je važno pridržavati se higijenskih standarda tijekom lova i evisceracije životinja, kao i tijekom proizvodnje, obrade i čuvanja kobasica od mesa divljači.
Interindividual Similarity of the Spatial Organization of the EEG: an Ontogenetic Study
Authors: Panasevich Е. А. , Tsitseroshin M. N.
Published: October 2024

In this study took part 39 adult subjects, 28 children 12 years old, 21 children 8–9 years old, 26 children 5–6 years old and 19 newborns. In each age group, the coefficient of interindividual similarity (CIS) of the spatial organisation of the electroencephalogram (EEG) was calculated using Pearson's crosscorrelation algorithm. Results reveal high level of interindividual similarity of spatial structure of EEG distant connections. Both in adults and children CIS exceeded 0.80. In women, compared with men, a significantly higher level of interindividual similarity of the spatial organization of the EEG was revealed for all studied combinations of EEG connections. The obtained data shows that relative stability in ontogenesis of the spatial structure of dynamic activity of the cortex is apparently provided mainly through determined by a genotype distant intra- and interhemispheric interconnections that forming certain morfofunctional “skeleton” of neocortex. The functionally specific interactions realizable across more plastic “local chains” of near intercortical interrelations are carried out on basis of the dynamic activity of the brain hemispheres that ordered by means of such “global” interactions. Such system organization of intercortical interactions can provide both safety of individual properties of personality and the ability of the brain to effectively adapt to various influences of environment at phenotype formation in ontogenesis.
Characteristics of Human Postactivation Effect of Skeletal Muscles Using Spectral and Non-Linear Parameters of the Surface Electromyogram
Authors: Meigal A. Yu. , Peskova A. E. , Sklyarova A. S. , Gerasimova-Meigal L. I.
Published: October 2024

Postactivation effect (PAE, postactivation phenomenon) is a specific type of involuntary muscle tone (tonic automatism) which is generated in the “tonogenic” structures of the brain, presumably without the “sensory copy” and “motor command” mechanisms. In this regard, the electromyogram (EMG) signal of PAE may have a simpler temporal signal structure compared to PAE-inducing voluntary activity. The purpose of this work is to characterize the temporal structure and complexity of surface EMG (sEMG) of the human deltoid and biceps brachii muscles using fractal (D) and correlation dimensions (Dc). It was found that in deltoid muscles the value of D was 1.78–1.81 both during PAE and voluntary effort (p 0.05). Dc (approximately 4.0–4.2) also did not differ between PAE and voluntary effort, although the average frequency of the sEMG spectrum during PAE was 15–16 Hz (p 0.05) higher compared to voluntary effort. In biceps brachii muscles, the D value was 1.8 during PAE and 1.62 during voluntary effort (p 0.05). Dc values did not differ between PAE and voluntary contraction (4–4.8). Thus, despite the supposed difference in the central organization of PAE and voluntary effort, the temporal structure of their sEMG did not differ, indicating that isometric voluntary effort and involuntary tone in the form of PAE share a common principle of sEMG signal generation. At the same time, the differences in the frequency of the sEMG spectrum indicate that the organization of sEMG signal during PAE is specific on the level of the motoneuron pool.
The Effect of Long-Term Physical Disability and Aging on Extracellular Matrix Biogenesis in Human Skeletal Muscle
Authors: Kurochkina N. S. , Lednev E. M. , Orlova M. A. , Vigovskiy M. A. , Zgoda V. G. , Vavilov N. E. , Vepkhvadze T. F. , Makhnovskii P. A. , Grigorieva O. A. , Boroday Y. R. , Philippov V. V. , Vyssokikh M. Yu. , Efimenko A. Yu. , Popov D. V.
Published: October 2024

Physical inactivity and aging cause significant impairments in the functionality and mechanical properties of skeletal muscles, as well as remodeling of the extracellular matrix (ECM). We aimed to study the effect of long-term inactivity and age on the biogenesis of ECM in skeletal muscle. For quantitative mass spectrometry-based proteomic analysis and RNA sequencing, biopsy samples were taken from m. vastus lateralis in 15 young healthy volunteers, 8 young and 37 elderly patients with long-term primary osteoarthritis of the knee/hip joint – which is a model for studying the effects of inactivity on muscles. We detected 1022 mRNAs and 101 ECM and associated proteins (matrisome). An increase in the expression of two dozen highly abundant matrisome proteins, specific to elderly and young patients (in relation to young healthy people), was detected; however, changes in the expression of mRNA encoding matrisome regulators (enzymatic regulators and secreted proteins) were similar. Comparison with previous proteomic and transcriptomic data showed that the changes in the matrisome that we described differed markedly from the changes caused by aerobic physical training in young healthy people, in particular, in the expression of the dominant ECM proteins and, especially, in the expression of mRNA of ECM enzymatic regulators and secreted proteins. Comparison of the changes in the expression profiles of these regulatory genes may be useful for identifying pharmacological targets for the prevention of adverse changes/activation of ECM biogenesis under various pathological conditions/physical training.
Rock art in the stone age of Gobustan: an archaeologist’s view
Authors: Amirkhanov Hizri A.
Published: October 2024

Gobustan is home to a large group of archaeological sites and many thousands of rock images dating from the Upper Palaeolithic to the Middle Ages. Due to its extraordinary scientific and artistic significance, the Gobustan complex is included in the UNESCO World Cultural Heritage List. This paper focuses on rock images dating back to the Stone Age. An attempt is made to systematize petroglyphs, taking into account their types, artistic styles, techniques of their creation, and themes of the images. The author considers relative dating and correlation of the distinguished styles with Gobustan sites of various stages of the Stone Age. Based on the analysis, style 1 of the region’s petroglyphs is dated from the first half of the Upper Palaeolithic (no later than 25–24 kya). Style 2 is synchronized with Mesolithic sites, and styles 3a and 3b are dated, with a certain degree of conditionality, from the Neolithic and Chalcolithic.
Window Glass of a Medieval Church at the Village of Veseloye Near Adler
Authors: Armarchuk Ekaterina A. , Kuzina Inna N.
Published: October 2024

Frequent finds from the excavations of a Christian church of the late 9th–11th century AD at the village of Veseloye (Greater Sochi) include fragments of unpainted and coloured window glass made by blowing in the disks shape, mostly, of 18 cm diameter. By the design of their edges, discs are divided into two types – one with a loop-shaped edge and one with a slightly thickened straight or slightly raised edge, and by the type of surface – smooth ones and those decorated with relief “optical” decor. A review of finds of medieval window glass over a wide area shows that finds from the Veseloye church fit into this array typologically and chronologically, which can be explained by the common technology of manufacturing this highly demanded glass product. In further research, it will be necessary to find out where window glass was produced for the churches of medieval Abkhazia and the Greater Sochi region.
New group of glazed Anatolian Pottery from the Ottoman fortress of Azak
Authors: Gusach Irina R.
Published: October 2024

The article introduces a new group of glazed pottery of Anatolian production from the archaeological studies of different years (1962, 2004, 2020) on the territory of the former Ottoman fortress of Azak in the North-Eastern Azov Region. Among the finds, there are 20 fragments of open shaped vessels (bowls, plates) and one fragment of the lid which originate from redeposited cultural layer of the site dated back to the late Middle Ages – Modern period. Close analogies can be found on the Crimean peninsula in the materials from the excavations in Sudak, Aluston, Cembalo, Mangup, Partenit, Biyuk-Lambat (Maly Mayak), and Chufut-Kale where they are generally dated by the last quarter of 15th–17th century AD, as well as in South-Western Georgia (Gonio fortress in Adjara) and on the Taman Peninsula (the Taman fortified settlement) in the cultural layer of the 16th–17th centuries AD. Production centre for this group of Ottoman pottery has not yet been established. The group got its conventional name ‘thick-walled bichrome bowls’ due to the dominant archaeological remains of thick-walled bowls with the characteristic decor style in the Crimea.
ВИКОРИСТАННЯ ГЕНЕРАТИВНОГО ШТУЧНОГО ІНТЕЛЕКТУ ДЛЯ АНАЛІЗУ ДАНИХ
Authors: ВАЙС Тімея , ОНИЩАК Назарій , ПОЛОВКО Іван , ШАРКАДІ Маріанна
Published: October 2024

У 2022 році розпочався новий етап розвитку штучного інтелекту. Багато компаній почали публікувати свої напрацювання та методології у цій сфері. Бурхливий розвиток дав можливість автоматизувати багато процесів рутинних справ у різних сферах життя та діяльності. Не стала винятком і сфера науки про дані та їхній аналіз. Актуальність задачі полягає у тому, щоб показати, що штучний інтелект є корисним у використанні для завдань аналізу даних. Завдяки цьому інструменту можна поглянути на задачу з іншої точки зору. В ході роботи завдяки генеративному штучному інтелекту було обрано набір даних, який зміг підібрати датасет так, щоб можна було розкрити метод кластеризації, прогнозування, а також ансамблевий метод машинного навчання. Дане дослідження показує, що використання штучного інтелекту є корисним, допомагає та дає поради щодо створення та ходу розробки коду.
Perubahan Karakteristik Kimia Selai Ubi Ungu terhadap Pemberian Variasi Bubur Nanas
Authors: Aprilliani Fenny , Rahayu Wiwik Endah
Published: October 2024

Selai merupakan produk makanan berupa pasta yang terbuat dari buah, sayuran atau umbi-umbian yang dihancurkan menjadi bubur dengan penambahan gula, asam, bahan pengental, serta bahan tambahan pangan yang diijinkan. Ubi ungu merupakan komoditas yang dapat dikembangkan menjadi selai. Substitusi bubur nanas dilakukan untuk meningkatkan cita rasa pada selai yang diproduksi. Tujuan pengujian ini yaitu untuk mengkaji pengaruh variasi substitusi bubur nanas terhadap karakteristik kimia selai. Metode yang digunakan yaitu Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dengan 3 kali ulangan. Perlakuan yang dilakukan yaitu substitusi bubur buah nanas yang terdiri dari P0 (0%), P1 (35%), P2 (40%) dan P3 (45%) dengan 3 kali pengulangan. Pengolahan data menggunakan ANOVA, yang dilanjutkan dengan Uji DNMRT taraf signifikan 5%. Hasil penelitian menunjukkan substitusi bubur buah nanas yang berbeda memberikan pengaruh yang nyata terhadap karakteristik kimia selai. Perlakuan terbaik dihasilkan dari sampel P3 dengan kandungan substitusi nanas sebesar 45% dengan karakteristik kadar air: 38,98±0,47d, pH: 4,29±0,01a, TPT: 8,00±0,10d%, TAT: 2,13±0,11d%, dan Vitamin C: 119,68±0,00d mg/100g.
Bidirectional ventricular tachycardia as a complication of uncontrolled digoxin intake: case report
Authors:   Russian University of Medicine, Moscow, Russian Federation, Peterburgsky D.V. ,   A.S. Puchkov Ambulance and Emergency Medical Care Station, Moscow, Russian Federation, Sinitsyn E.A. ,   Russian University of Medicine, Moscow, Russian Federation,   Research Institute of Pulmonology of the Russian Federal Medical Biological Agency, Moscow, Russian Federation, Smolyakova E.V. ,   Russian University of Medicine, Moscow, Russian Federation, Zykov K.A. ,   Russian University of Medicine, Moscow, Russian Federation,   Research Institute of Pulmonology of the Russian Federal Medical Biological Agency, Moscow, Russian Federation
Published: October 2024

Cardiac glycosides (CG) are one of the first drug groups that have been used in the treatment of cardiac diseases for more than 200 years. Despite this, their use is still a matter of dispute and constant discussion within the medical community. It is known that CG increases the myocardial contractility, slows down conduction in the atrioventricular node, which helps delaying the heart rate and improves systemic hemodynamics in atrial fibrillation (AF) during heart failure. Despite this, CG has not been a first-line drug for a long time. Among CGs, digoxin is used as the most studied drug in many clinical studies. Taking digoxin is commonly associated with the development of adverse events such as bradycardia, ventricular extrasystole, nausea, vomiting. One of the most dangerous side effects of CG is considered to be a pro-arrhythmogenic effect, in particular, their ability to provoke ventricular tachycardia. The authors present a case study of rare bidirectional ventricular tachycardia in a 78-year-old female patient with a persistent AF during long-term uncontrolled digoxin intake. Analyzing this case, the authors conclude that more careful follow-up of long-term digoxin intake is necessary to exclude the development of its side effects. KEYWORDS: case study, bidirectional ventricular tachycardia, atrial fibrillation, cardiac glycosides, digitalis toxicity. FOR CITATION: Peterburgsky D.V., Sinitsyn E.A., Smolyakova E.V., Zykov K.A. Bidirectional ventricular tachycardia as a complication of uncontrolled digoxin intake: case report. Russian Medical Inquiry. 2024;8(7):386–390 (in Russ.). DOI: 10.32364/2587-6821-2024-8-7-2.
Asymptomatic hyperuricemia effect on the course, outcomes and comorbid conditions in systemic lupus erythematosus. Modern view of the problem
Authors:   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation, Musiychuk M.M. , Gaydukova I.Z. ,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation,   Clinical Rheumatological Hospital No. 25, St. Petersburg, Russian Federation, Inamova O.V. ,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation,   Clinical Rheumatological Hospital No. 25, St. Petersburg, Russian Federation, Aparkina A.V. ,   V.I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation, Rebrov A.P. ,   V.I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation
Published: October 2024

The considerable prevalence of asymptomatic hyperuricemia (HU) in the general population underscores the need for an in-depth investigation into its impact on the progression of various diseases, including rheumatological and comorbid conditions. This literature review elucidates the association between HU and systemic lupus erythematosus (SLE) and examines the pathogenetic and clinical foundations for implementing urate-lowering therapy in individuals with concurrent HU and SLE. It has been demonstrated that elevated serum uric acid (UA) levels correlate with an increased risk of pulmonary hypertension, stroke, arterial hypertension, hyperlipidemia, and metabolic syndrome. The mechanisms through which HU contributes to renal damage are explored independently, highlighting the challenges in ascertaining the primary etiology of renal disorder. Although direct interventional studies validating the necessity of urate-lowering therapy in patients with SLE, HU, and comorbidities (particularly cardiovascular diseases) are not currently available, there is substantial evidence supporting the beneficial impact of UA level normalization on cardiovascular outcomes. Given the negative impact of elevated UA levels on comorbid conditions that crucially influence the life expectancy of SLE patients (such as cardiovascular disease and chronic kidney disease), lifelong management of UA levels is advisable for individuals with SLE. KEYWORDS: systemic lupus erythematosus, hyperuricemia, comorbidity, metabolic syndrome, comorbid conditions, urate-lowering therapy. FOR CITATION: Musiychuk M.M., Gaydukova I.Z., Inamova O.V., Aparkina A.V., Rebrov A.P. Asymptomatic hyperuricemia effect on the course, outcomes and comorbid conditions in systemic lupus erythematosus. Modern view of the problem. Russian Medical Inquiry. 2024;8(7):391–399 (in Russ.). DOI: 10.32364/2587-6821-2024-8-7-4.
Matrix metalloproteinases are a promising therapeutic target for the osteoarthritis treatment
Authors:   Bashkir State Medical University, Ufa, Russian Federation, Tyurin A.V. , Gaydukova I.Z. ,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation, Akhiyarova K.E. ,   Bashkir State Medical University, Ufa, Russian Federation, Galina I.I. ,   Bashkir State Medical University, Ufa, Russian Federation, Khusainova R.I. ,   Bashkir State Medical University, Ufa, Russian Federation,   National Medical Research Center of Endocrinology, Moscow, Russian Federation
Published: October 2024

Osteoarthritis (osteoarthrosis) is one of the most common pathologies of the musculoskeletal system, primarily among the elderly, who present typical clinical symptoms such as joint pain, swelling, stiffness and motion limitation. This can lead to a decrease in physical activity and quality of life, in addition to increasing the socio-economic burden on patients and society as a whole. According to data from 2017, more than 303 million people worldwide suffer from osteoarthritis, which makes this disease socially significant. Consonant to modern concepts, osteoarthritis is a joint disease characterized by cellular stress and degradation of the extracellular matrix resulting from macro/micro-injuries that activate pathological adaptive restorative responses, including pro-inflammatory pathways of the immune system. A long-term research period into the pathogenesis of this disease did not allow the development of treatment and prevention techniques that would completely solve the problem of osteoarthritis high incidence. Currently, a pertinent research area is the investigation of this disease phenotypes with particular emphasis on phenotypes associated with inflammation and connective tissue metabolism. An urgent task is to identify the factors regulating these conditions, namely pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukins 1, 6, 18 and catabolism enzymes — matrix metalloproteinases (MMPs), since they can become potential new therapy targets. Most MMPs, including MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13 and MMP-14, are involved in the metabolism of the extracellular matrix and the associated destruction of articular cartilage in osteoarthritis. This article is devoted to determining the role of inflammatory mediators, MMPs in the osteoarthritis pathogenesis and reviewing new pathogenetically justified treatment options for this disease. KEYWORDS: osteoarthritis, inflammation, matrix metalloproteinases, therapy targets, connective tissue. FOR CITATION: Tyurin A.V., Gaydukova I.Z., Akhiyarova K.E., Galina I.I., Khusainova R.I. Matrix metalloproteinases are a promising therapeutic target for the osteoarthritis treatment. Russian Medical Inquiry. 2024;8(7):400–405 (in Russ.). DOI: 10.32364/2587-6821-2024-8-7-5.
Сase of multi-focal osteonecrosis with secondary osteoarthritis and glucocorticoid-induced osteoporosis in an adult patient with juvenile-onset systemic lupus erythematosus — risk factors and modern treatment tactics
Authors:   North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation, Gaydukova I.Z. ,   Clinical Rheumatological Hospital No. 25, St. Petersburg, Russian Federation, Musiychuk M.M. ,   Clinical Rheumatological Hospital No. 25, St. Petersburg, Russian Federation, Bombina M.V. ,   Clinical Rheumatological Hospital No. 25, St. Petersburg, Russian Federation, Aparkina A.V. ,   V.I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation, Petukhova A.A. ,   North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation, Filonenko E.P. ,   North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation, Inamova O.V. ,   North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation,   Clinical Rheumatological Hospital No. 25, St. Petersburg, Russian Federation, Rebrov A.P. ,   V.I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation
Published: October 2024

The article presents the case analysis concerning the successful therapeutic treatment of multiple osteonecrosis in an adult female patient with the juvenile form of systemic lupus erythematosus (SLE), including an analysis of the risk factors for their development. A comprehensive approach, including limiting axial load on the hip joints, the use of bisphosphonates, teriparatide, nonsteroidal anti-inflammatory drugs (NSAIDs), and disease-modifying osteoarthritis drugs, resulted in pain reduction, slowing of structural progression of femoral head changes, and improved functional status of the patient. Disease-modifying treatment of osteoarthritis was conducted with alternating injectable and oral medications. The success in treating osteonecrosis in this female patient was also enabled by the adjustment of basic SLE therapy and the reduction of prednisone dosage to 1.25 mg/day. This case serves as a vivid illustration of what is referred to as "complicated comorbidity.» The comprehensive approach allowed for achieving sustained positive outcomes, thus postponing surgical intervention in a physically active young female patient. KEYWORDS: systemic lupus erythematosus, SLE, aseptic necrosis, risk factors, osteoarthritis, osteoporosis, basic therapy of osteoarthritis, DMOAD, bisphosphonates, glucocorticoids. FOR CITATION: Gaydukova I.Z., Musiychuk M.M., Bombina M.V., Aparkina A.V., Petukhova A.A., Filonenko E.P., Inamova O.V., Rebrov A.P. Сase of multi-focal osteonecrosis with secondary osteoarthritis and glucocorticoid-induced osteoporosis in an adult patient with juvenile- onset systemic lupus erythematosus — risk factors and modern treatment tactics. Russian Medical Inquiry. 2024;8(7):406–412 (in Russ.). DOI: 10.32364/2587-6821-2024-8-7-6.
Generalized pustular psoriasis and psoriatic spondyloarthritis: therapeutic options in real clinical practice
Authors:   St. Petersburg State University Hospital, St. Petersburg, Russian Federation, Vasilenko E.A. , Tarasova D.S. ,   St. Petersburg State University Hospital, St. Petersburg, Russian Federation, Maksimova M.D. ,   St. Petersburg City Skin and Venereological Dispensary, St. Petersburg, Russian Federation, Samigullina R.R. ,   North West State Medical University named after I.I.Mechnikov, St. Petersburg, Russian Federation, Raznatovskiy K.I. ,   North West State Medical University named after I.I.Mechnikov, St. Petersburg, Russian Federation, Mazurov V.I. ,   North West State Medical University named after I.I.Mechnikov, St. Petersburg, Russian Federation
Published: October 2024

Generalized pustular psoriasis (GPP) represents one of the most severe and challenging variants of psoriasis to manage. The global literature primarily documents isolated clinical instances of GPP coexisting with peripheral arthritis, while the occurrence of spondyloarthritis in these patients remains exceedingly rare. This article compiles and analyzes clinical data and treatment guidelines for managing GPP in conjunction with psoriatic spondyloarthritis (PSpA) from various international sources. It also examines recent publications regarding the development, administration, and efficacy of novel targeted therapies. In addition to existing literature, the author shares personal experience in the effective treatment of a GPP patient with concurrent PSpA using a genetically engineered biological drug (GEBD), specifically the interleukin-17 inhibitor netakimab. Administering advanced therapeutic strategies like GEBD is recommended, especially in cases where conventional therapies with basic anti-inflammatory and non-steroidal anti-inflammatory drugs prove ineffective. Owing to the paucity of extensive multicenter studies and absence of GPP registries of patients with PSpA, the formulation of interdisciplinary treatment algorithms remains a critical challenge for both dermatovenerologists and rheumatologists. KEYWORDS: generalized pustular psoriasis, psoriatic spondyloarthritis, psoriasis, genetically engineered biological therapy, interleukin-17 inhibitors, netakimab. FOR CITATION: Vasilenko E.A., Tarasova D.S., Maksimova M.D., Samigullina R.R., Raznatovskiy K.I., Mazurov V.I. Generalized pustular psoriasis and psoriatic spondyloarthritis: therapeutic options in real clinical practice. Russian Medical Inquiry. 2024;8(7):413–420 (in Russ.). DOI: 10.32364/2587-6821-2024-8-7-7.
The Impact of Leadership Practices on the Adoption of Digital Transformation: The Moderating Role of Organizational Culture in Jordanian Manufacturing Sector
Authors: Khalayleh Wiam , Rohaida Siti , Al-Khazaleh Suhaib Mohammed
Published: October 2024

This study investigates how organizational culture influences the relationship between leadership practices and digital transformation, as well as the impact of digital leadership practices on the adoption of digital transformation inside organizations. Using a quantitative approach, data from numerous firms reveal that achieving digital transformation necessitates effective leadership, with specific leadership components such as communication, strategic planning, digital leadership, and continuous improvement being crucial. The findings show that, depending on how effectively organizational culture fits with leadership initiatives, it can either facilitate or delay digital change. The study underlines the importance of purposeful investments in leadership development and cultural alignment for successful digital disruption management. While emphasizing the importance of cultivating an innovative culture and giving leaders with practical insights.
The Effect of Risk Perception and Online Trust on Purchase Intention in E-Commerce
Authors: Ikhlash Muhamammad , Linda Khori Rahma
Published: October 2024

Research on the factors influencing online trust in e-commerce has been limited in recent years. Therefore, this study is a rigorous investigation that aims to first understand the main factors that affect online trust and, second, to find out the impact of online trust on risk perception, attitude, and purchase intention. The study applies a quantitative approach method and collects primary data by filling out questionnaires from 100 respondents who have experience shopping through e-commerce applications. The sampling technique uses the purposive sampling method, ensuring a representative sample. Data collection was carried out by distributing questionnaires, and then the data was processed using SmartPLS version 4.0 to test instruments and hypotheses. The findings of this study, based on a robust methodology, show that perceived size has a significant positive effect on online trust, perceived reputation has a significant positive effect on online trust, online trust has a significant positive effect on risk perception, online trust has a significant positive effect on attitude, Risk perception has a significant positive effect on attitude, risk perception does not affect purchase intention, attitude has a significant positive effect on purchase intention, and online trust does not affect purchase intention.
Exploring the Relationship Between Business Strategy and Project Management Tools and Techniques: A Case Study in the Marketing Industry
Authors: Herzing Ian M.
Published: October 2024

Project management tools and techniques (PMTT) have been understudied in marketing. This research explored PMTT alignment with business strategy in a marketing agency via a qualitative case study. Data collection involved a focus group, questionnaires, and interviews examining how PMTT influence schedules, quality, budgets, and clients. Analysis revealed selection and use of PMTT is driven by strategic emphasis on agility, cost- efficiency, and client needs. Findings confirmed PMTT’s role in meeting timelines and budgets while ensuring quality. A proposed matrix connects PMTT with strategy. Though a single case, the study provides templates to match PM toolkits to business strategy. Further research can build on the strategic and contingency insights regarding adaptable PMTT use. Overall, findings advance practical relevance through strategy-linked PMTT customization suited to this project-focused creative context.
Investigating the Impact of Digital Leadership Dimensions on Service Economics Dimensions: An Empirical Study of Service Ministries in the Kingdom of Saudi Arabia
Authors: Abdulrahman Badreldin Mohamed Ahmed , Mohammed Sanaa Mostafa
Published: October 2024

This study examines the influence of various aspects of digital leadership (such as digital culture, visionary planning, system design, empowering leadership, employee development, innovation, persuasion, and knowledge) on different dimensions of service economics (including innovative economic ideas, efficient use of economic resources, leadership behaviors, and economic learning) within service ministries in the Kingdom of Saudi Arabia. We used a quantitative technique to collect data from a sample of 475 workers involved in service ministries via the use of a survey questionnaire. We conducted a thorough study of the data using the method of multiple regression analysis. The findings indicate that the different components of digital leadership have a significant and advantageous impact on the variables associated with service economics. The research determined that digital culture, innovation, and employee professional development are the main characteristics that have a major impact on digital leadership. This study contributes to the current literature by providing empirical evidence on the relationship between digital leadership and service economics. Additionally, it offers practical suggestions for service ministries in Saudi Arabia to enhance their service economics via the implementation of effective digital leadership methods. Nevertheless, the study is subject to many limitations, including its cross-sectional design and its narrow emphasis on a particular environment. It is recommended that future research endeavors address these constraints.
Commercial Diplomacy and Internationalization of SMEs: A Scoping Review
Authors: Alsuwaidi Fatima , Raziq Muhammad , Batool Uzma
Published: October 2024

The purpose of this study is to synthesize information about the possible advantages of SME internationalization. The primary question driving this scoping review is: What is the extent to which field of commercial diplomacy has identified its potential to benefit the SMEs, specifically in their internationalization efforts? We do have done a scoping review adhering to a five-step methodology, and extensively reviewing the relevant studies. A systematic literature review was conducted using electronic databases with predefined inclusion-exclusion criteria. 191 articles were screened, yielding 19 relevant studies for final analysis. Our review not only offers a comprehensive analysis of the current research on the relationship between CD and SME internationalization, but also identifies key themes. While doing so, this study sheds light on significant findings, on-going debates, and identifies research gaps that need future exploration. The study’s theoretical and practical implications are also discussed. The role of SMEs in economic growth and innovation is crucial in the context of globalization. Nevertheless, SMEs have several internal and external challenges throughout their process of internationalization. Despite the established significance commercial diplomacy plays in the internationalization efforts of SMEs, centre of attention remains on large organization and their facilitation. While the current body of research mostly focuses on the economic consequences of internationalization for bigger companies, it remains limited on SMEs.
Going the Extra Mile: What Drives Employee Voluntarism in Public Sector Organizations?
Authors: Saud Jenna , Rice John Lewis
Published: October 2024

This research intends to investigate the impact of employee age and innovative work climate on the relationship between supportive supervisory roles and employee acts of voluntarism. Using a large cross-sectional survey of the Australian Public Service we find that the influence of supportive supervisors on employees’ acts of voluntarism and extra role behaviors at work is higher amongst younger employees. This indicates that younger employees are more likely to engage in acts of voluntarism as a result of supportive supervisory roles. Findings also indicate that innovative work climate accentuates the relationship between supportive supervisory behaviors and acts of voluntarism. Employees who experience high levels of innovative work climate and high levels of support from supervisors tend to display higher levels of voluntarism and extra role behaviors at work. These findings have several theoretical and practical implications.
Developing Green Marketing Strategies: A Comprehensive Analysis of Consumer Behaviour and Business Practices
Authors: Mansour Ahmad , Al-Ahmed Hind , Deek Anan , Alshaketheep Khaled , Al-Ma'aitah Mohammad , Asfour Bara , Alshurideh Muhammad
Published: October 2024

The purpose of this research is to examine the relationship between green marketing communication techniques, consumer behaviour patterns, and business organisations’ practices by employing both qualitative and quantitative methodologies. A hypothesized quantitative survey with 500 consumers and a qualitative case study of leading organisations to assess modern tendencies and approaches were carried out. The quantitative analysis shows that 70% of the consumers take environmental concern while purchasing products, but only 45% are ready to pay the premium price for green products. Moreover, there is a low level of confidence in green claims where only 30% of the consumers are confident that firms have sincere intentions about the statements they make. An analysis of Nike, Starbucks, and Toyota, Apple, and Microsoft organizations shows that they incorporate different strategies in supply chain management, carbon footprint, corporations’ responsibility, and customer relations. Some of these firms focus on the promotion of the company’s transparency, product sourcing based on an ethical approach, encouragement of the use of renewables, as well as community involvement in fulfilling sustainable objectives. Thus, the study also stresses the importance of clarity within communication channels and information reliability for the development of consumers’ trust. It defines factors like the cost and every person’s doubt or disbelief in what is green that prevents an extensive use of green products. Altogether, this research contributes useful knowledge for companies wanting to implement suitable green marketing initiatives that would be appealing to eco-aware consumers. It is clear that implementing corporate practice according to the customer expectation and practicing transparency would not only increase the brand value but also the customer loyalty and which in longer runs would also help in supporting and implementing sustainable development goals across the world.
Metode Pengumpulan Data Debit Air Pada Saluran Distribusi Air PDAM Makassar Berbasis IoT
Authors: Imran Andi , Nurul Azizah  , Gunawan Zain Satria , Zulhajji  , Ajiatmo Dwi
Published: October 2024

Water is an important resource for human survival as well as various economic sectors. PDAM is responsible for providing water supply to the community. One of the major challenges faced in managing water supply is the problem of water loss or leakage. This research aims to overcome this problem by designing an innovative method to collect water discharge data on the distribution channel of PDAM Makassar using Internet of Things (IoT) technology. This method uses the ESP32-CAM to take images of the water meter on the main pipe and save it to a database. Optical Character Recognition (OCR) technology is used to convert the image into text that can be processed. The test results show that the average error in meter readings is 0.215% with an average accuracy rate of 98%. Overall the system works well in reading digital meters and is reliable in monitoring water consumption visually and in real-time. Thus, this method can be an effective solution in detecting water leaks and improving the efficiency of water supply management by PDAMs, as well as saving resources and operational costs.
Pengaruh Penambahan Transformator Sisip pada Trafo Distribusi 200 kVA Kayu Merah Kabupaten Fakfak
Authors: Yulianto La Elo  , Lembang Naomi , Tianotak Siti
Published: October 2024

Permasalahan ketenagalistrikan di Kabupaten Fakfak bukan hanya terjadi oleh akibat terbatasnya pasokan listrik yang disalurkan oleh PLN, namun juga terjadi akibat proses distribusi listrik ke Masyarakat. Salah satu masalah yang seringkali terjadi adalah presentasi penggunaan tranformator yang telah melebihi dari ketentuan PLN yang mana pembebanan normal transformator adalah 60 % - 80%. Penyulang Danaweria merupakan salah satu penyulang yang seringkali mendapat keluhan dari konsumen Listrik PLN di Kabupaten Fakfak dimana sampai mengakibatkan terjadinya pemadaman listrik oleh PLN. Jika hal ini terus dibiarkan, maka tentu akan mengakibatkan kerusakan pada gardu distribusi yang akan merugikan pihak PLN sebagai penyedia  dan masyarakat sebagai konsumen listrik. Melalui pemasangan transformator sisipan, diharapkan dapat mengurangi beban pada gardu distribusi dengan memindahkan beban ke gardu sisipan. Dalam penelitian ini akan mengkaji terkait pemasangan transformator sisipan untuk mengurangi beban pada gardu distribusi FFK 058, 200kVA Penyulang Danaweria di PT. PLN (Persero) ULP Fakfak, dengan memindahkan sebagian beban ke transformator sisipan 100 kVA. Setelah pemasangan trafo sisipan, beban puncak siang hari dari trafo FFK 058, 200 kVA diperoleh presentase pembebanan sebesar 35,4% dari sebelumnya sebesar 61,07%. Sedangkan pada malam hari, presentase pembebanan sebesar 55,7 % dari sebelumnya 98,23%.  Hasil tersebut menunjukan presentasi pembebanan dalam keadaan normal sesuai ketentuan PLN
TINGKAT MUTU HEDONIK BEKASEM IKAN NILA PADA LAMA FERMENTASI YANG BERBEDA
Authors: Junianto  , Elyzha Adhinda Nurr , Marsyal Muhammad Guntur , Hardianto Putra Ananda Nurrafi Feryansyah
Published: October 2024

Fish is an economical food source and offers a more affordable alternative compared to beef and chicken. One of the commodities suitable as an inexpensive, easily found, and cultivated food with high protein value is tilapia. However, tilapia is perishable if not handled quickly or stored at low temperatures. To extend the shelf life of tilapia, processing is needed to maintain both the shelf life and the quality of the product, one of which is through fermentation. One traditional fermentation method frequently used by the people of South Sumatra is Bekasam. This study aims to determine the effect of the fermentation duration of Bekasam tilapia on its preference level or hedonic quality. Observations were made on days 3, 5, 7, 8, and 9 with organoleptic and hedonic tests on those days. The method used in this research is an experimental method. Non-parametric data from the organoleptic tests were analyzed using the Friedman test, followed by ANOVA. The parameters tested included pH, appearance, aroma, taste, and texture of Bekasam tilapia. The results showed that Bekasam tilapia with 3 days of fermentation provided the best results with a pH of 6.40, and the preference scores for appearance, taste, aroma, and texture were 5.00c, 4.33c, 5.91c, and 6.47c, respectively
ANALISA ANTRIAN PELAYANAN KESEHATAN PADA POLI UMUM PUSKESMAS X KOTA DUMAI DENGAN SIMULASI PROMODEL
Authors: Azmi  , Wetri Febrina  , Elisa Hafrida  , Trisna Mesra  , Fitra Fitra
Published: October 2024

Penelitian ini bertujuan untuk menganalisis sistem antrian dan kinerja pelayanan kesehatan di Puskesmas X Kota Dumai dengan menggunakan simulasi komputer melalui Software Promodel. Fokus utama adalah pada loket pendaftaran, poli umum, dan tempat pengambilan obat, yang sering mengalami antrian panjang dan menjadi indikator penting dalam menilai kualitas layanan. Metodologi penelitian berorientasi pada pengembangan dan analisis sistem dengan menggunakan simulasi karena fluktuatifnya jumlah pasien yang datang setiap harinya, begitu pula dengan waktu pelayanan yang bervariasi untuk setiap pasien. Hasil simulasi menunjukkan bahwa waktu kedatangan pasien dan waktu pelayanan di setiap lokasi memiliki dampak signifikan terhadap durasi antrian dan kepuasan pasien. Berdasarkan hasil simulasi, ditemukan bahwa loket pendaftaran dan apotek merupakan dua area kritis yang memerlukan evaluasi dan peningkatan kinerja. Khususnya, disarankan penambahan satu petugas di loket pendaftaran dan satu petugas di apotek untuk mengurangi waktu tunggu dan meningkatkan efisiensi layanan.
 
Kata kunci: Antrian, Promodel, Puskesmas