bluuebunny/crossref_metadata_2025 huggingface dataset:
Materials Informatics: Statistical Modeling in Material Science
Authors: Yosipof Abraham , Shimanovich Klimentiy , Senderowitz Hanoch
Published: August 2016

Material informatics is engaged with the application of informatic principles to materials science in order to assist in the discovery and development of new materials. Central to the field is the application of data mining techniques and in particular machine learning approaches, often referred to as Quantitative Structure Activity Relationship (QSAR) modeling, to derive predictive models for a variety of materials‐related “activities”. Such models can accelerate the development of new materials with favorable properties and provide insight into the factors governing these properties. Here we provide a comparison between medicinal chemistry/drug design and materials‐related QSAR modeling and highlight the importance of developing new, materials‐specific descriptors. We survey some of the most recent QSAR models developed in materials science with focus on energetic materials and on solar cells. Finally we present new examples of material‐informatic analyses of solar cells libraries produced from metal oxides using combinatorial material synthesis. Different analyses lead to interesting physical insights as well as to the design of new cells with potentially improved photovoltaic parameters.
Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla
Authors: Clarke William T. , Robson Matthew D. , Neubauer Stefan , Rodgers Christopher T.
Published: August 2016

Purpose

We present a new Bloch‐Siegert four Angle Saturation Transfer (BOAST) method for measuring the creatine kinase (CK) first‐order effective rate constant kf in human myocardium at 7 tesla (T). BOAST combines a variant of the four‐angle saturation transfer (FAST) method using amplitude‐modulated radiofrequency pulses, phosphorus Bloch‐Siegert
‐mapping to determine the per‐voxel flip angles, and nonlinear fitting to Bloch simulations for postprocessing.

Methods

Optimal flip angles and repetition time parameters were determined from Monte Carlo simulations. BOAST was validated in the calf muscle of two volunteers at 3T and 7T. The myocardial CK forward rate constant was then measured in 10 volunteers at 7T in 82 min (after 1H localization).

Results

BOAST
values were 0.281 ± 0.002 s−1 in the calf and 0.35 ± 0.05 s−1 in myocardium. These are consistent with literature values from lower fields. Using a literature values for adenosine triphosphate concentration, we computed CK flux values of 4.55 ± 1.52 mmol kg−1 s−1. The sensitive volume for BOAST depends on the B1 inhomogeneity of the transmit coil.

Conclusion

BOAST enables measurement of the CK rate constant in the human heart at 7T, with spatial localization in three dimensions to 5.6 mL voxels, using a 10‐cm loop coil. Magn Reson Med 78:20–32, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Gradient polymer networks formed by photopolymerization with self‐floating polysiloxane‐containing nanogel
Authors: Chen Cong , Han JunYi , Sun Fang
Published: August 2016

Polysiloxane‐containing nanogels can be used as a fast, convenient and environmentally friendly method to control gradient photopolymerization and to obtain gradient polymer network because of its self‐floating feature. The chain length of polysiloxane is a key factor that influences the self‐floating capability of the polysiloxane‐containing nanogel. This paper reports a series of nanogels compositions synthesized with methacrylate‐modified polysiloxanes with different chain lengths, urethane dimethacrylate (UDMA) and isobornyl methacrylate (IBMA) at a molar ratio of 10:20:70 in the presence of a thiol chain transfer agent. The effect of polysiloxane chain length on self‐floating capability of the nanogel and gradient polymer network was researched. The results show that polysiloxane chain length is the main driving force for the self‐floating capability of the nanogels. The nanogel with long polysiloxane chain length exhibits good self‐floating capability in the monomer–polymer matrix because of the lower surface tension of polysiloxane. Furthermore, the gradient polymer network containing the nanogel with long polysiloxane chain length presents lower dispersion surface energy and greater hardness and thermostability. Copyright © 2016 John Wiley & Sons, Ltd.
Photo‐enhanced catalytic activity of spray‐coated Cu2SnSe3 nanoparticle counter electrode for dye‐sensitised solar cells
Authors: Ananthakumar Soosaimanickam , Li Xuan , Anderson Ann‐Louise , Yilmaz Pelin , Dunn Steve , Babu Sridharan Moorthy , Briscoe Joe
Published: August 2016

Cu2SnSe3 nanoparticles are synthesised using oleylamine as both a solvent and capping agent and spray coated to form dye‐sensitised solar cell (DSSC) counter electrodes (CEs) using earth‐abundant elements. The film requires annealing at only 400 °C in nitrogen, which is a lower temperature than previous reports of both Cu2SnSe3and Cu2ZnSnSe4 films, also avoiding the use of Se gas. The composition and phase of the material is confirmed to be kesterite Cu2SnSe3. DSSCs using Cu2SnSe3 CEs give a power conversion efficiency of 4.87%, compared to 5.35% when using Pt. Electrochemical impedance spectroscopy indicates that the performance of the Cu2SnSe3 CE is enhanced under illumination, leading to a drop in the charge transfer resistance. This illumination‐induced enhancement of the catalytic activity provides a novel mechanism for the enhancement of CE performance in DSSCs.

magnified image

Photo‐excitation of the nanostructured Cu2SnSe3 counter electrode provides a higher overpotential for electrolyte reduction, giving improved catalytic performance.
Mass spectrometry based strategy for studies of binding sites and structural changes of cisplatin binding to myoglobin
Authors: Liu Huan , Zhang Ningbo , Cui Meng , Liu Zhiqiang , Liu Shuying
Published: August 2016

Rationale

It is of great significance to investigate the interaction of the metallodrug cisplatin (cis‐[PtCl2(NH3)2]) with myoglobin for understanding of the mechanism of action of cisplatin and the overexpression of myoglobin in tumor cells.

Methods

The reactions of cisplatin and myoglobin were incubated under different conditions. A mass spectrometry (MS)‐based strategy combining full proteolysis and limited proteolysis was developed for comprehensive studies of cisplatin‐myoglobin interaction.

Results

The binding sites of cisplatin on myoglobin were identified as Trp14, His64, His81, His113 and His116 using electrospray ionization multiple‐stage tandem mass spectrometry (ESI‐MSn) without liquid chromatography (LC) separation. The relative abundances of digested peptides from platinated myoglobin were obviously higher than those from native samples by limited proteolysis.

Conclusions

An alternative and simple approach was developed to successfully monitor conformational changes of myoglobin induced by cisplatin binding using an ESI‐MS‐based quantification method combined with limited proteolysis. Meanwhile, His64 was firstly found to coordinate to platinum, which was likely to affect hydrogen bonds with the oxygen in the heme group. Copyright © 2016 John Wiley & Sons, Ltd.
Consumer desire for control as a barrier to new product adoption
Authors: Faraji‐Rad Ali , Melumad Shiri , Johar Gita Venkataramani
Published: August 2016

This research examines the relationship between desire for control and acceptance of new products. We hypothesize that desire for control—the need to personally control outcomes in one's life—acts as a barrier to new product acceptance. Three experiments provide support for this hypothesis. This effect holds when desire for control is high as a dispositional trait (Studies 1 and 3) and when it is situationally induced (Study 2). We also identify an intervention to increase new product acceptance based on the idea that new products threaten one's sense of control. Specifically, framing new products as potentially enhancing one's sense of control increases acceptance of new products by those high in desire for control (Study 3). This finding offers some evidence for the underlying process and helps guide managerial actions.
Partner Relationships and Health: Marital Quality and Health Among Peri-Urban Ethiopian Couples
Authors: John Neetu A. , Seme Assefa , Tsui Amy O.
Published: August 2016

The linkages between marital relationship quality (MRQ) and health are well established in the West, although mutual spousal influence on each other is underexplored. In the sub-Saharan African context, despite continued health challenges and changing marital structures, this research has been neglected. This study examined the influence of spousal MRQ domains — such as trust, commitment and conflict resolution — on each other's self-reported health over time, using two waves of data from 725 couples in peri-urban Ethiopia using the Actor Partner Interdependence Model. Although MRQ and self-rated health measures of wives and husbands were associated, these relationships were complex and gendered. While the wife's health rating had a positive influence on the husband's relationship quality, the husband's health ratings were negatively associated with the wife's relationship quality. Expanding knowledge on the role of spousal influence can broaden understanding of couple mechanisms that potentially promote positive health behaviours and protect the health of spouses in different settings.
The Chemical Composition of the Galactic Bulge and Implications for its Evolution
Authors: McWilliam Andrew
Published: August 2016

At a bulge latitude ofb= −4°, the average [Fe/H] and [Mg/H] values are +0.06 and +0.17 dex, roughly 0.2 and 0.7 dex higher than the local thin and thick disk values, respectively, suggesting a large bulgeeffective yield, perhaps due to efficient retention of supernova ejecta.

The bulge vertical [Fe/H] gradient, at ~ 0.5 dex/kpc, appears to be due to a changing mixture of sub-populations (near +0.3 dex and −0.3 dex and one possibly near −0.7 dex) with latitude. At solar [Fe/H], the bulge [Al/Fe] and [α/Fe] ratios are ~ +0.15 dex. Below [Fe/H] < ![CDATA[$ ~ −0.5 dex, the bulge and local thick disk compositions are very similar; but the measured [Mg/Fe], [⟨SiCaTi⟩/Fe], [La/Eu] and dramatic [Cu/Fe] ratios suggest higher SFR in the bulge. However, these composition differences with the thick disk could be due to measurement errors and non-LTE effects.

Unusual zig-zag trends of [Cu/Fe] and [Na/Fe] suggest metallicity-dependent nucleosynthesis by core-collapse supernovae in the Type Ia supernova time-delay scenario.

The bulge sub-population compositions resemble the local thin and thick disks, but at higher [Fe/H], suggesting a radial [Fe/H] gradient of − $0.04]] > to − 0.05 dex/kpc for both the thin and thick disks. If the bulge formed through accretion of inner thin and thick disk stars, it appears that these stars retained vertical scale heights characteristic of their kinematic origin, resulting in the vertical [Fe/H] gradient and [α/Fe] trends seen today.
Religious Symbols, Multiculturalism and Policy Attitudes
Authors: Stolle Dietlind , Harell Allison , Soroka Stuart , Behnke Jessica
Published: August 2016

Multicultural policy is an increasingly salient, and contested, topic in both academic and public debate about how to manage increasing ethnic diversity. In spite of the longstanding commitment to multiculturalism policy in Canada, however, we have only a partial understanding of public attitudes on this issue. Current research tends to look at general attitudes regarding diversity and accommodation–rarely at attitudes towards specific multicultural policies. We seek to (partly) fill this gap. In particular, we focus on how support for multiculturalism policy varies across benefit types (for example, financial and other) and the ethnicity/religiosity of recipient groups. Using a unique survey experiment conducted within the 2011 Canadian Election Study (CES), we examine how ethnic origin (Portuguese vs. Turkish) and religious symbols (absence and presence of the hijab) influence support for funding of ethno-religious group activities and their access to public spaces. We also explore whether citizens’ general attitudes toward cultural diversity moderate this effect. Results provide important information about the state of Canadian public opinion on multiculturalism, and more general evidence about the nature, authenticity and limits of public support for this policy.
Strategies of plankton occupation by polychaete assemblages in a subtropical estuary (south Brazil)
Authors: Nogueira Júnior Miodeli , Maria de Oliveira Verônica
Published: August 2016

Polychaete abundance and assemblage structure were analysed from 144 zooplankton samples taken in eight seasonal campaigns between October 2007 and November 2008 on Babitonga Bay estuary (south Brazil). A total of 16 taxa were found, classified in three categories: (i) larvae (five taxa) dominated byLoimiasp. (Terebellidae) (up to 59 ind 100 m−3); (ii) syllid epitokes (three taxa) dominated byProcerasteasp.2 (up to 11 ind 100 m−3) andMyrianidasp. (up to 6 ind 100 m−3); and (iii) adults of typically benthic species (eight taxa) which were only occasionally sampled in low densities (<1 ind 100m−3). Larvae dominated mostly during spring and summer in the outer sector of the estuary, while syllid epitokes peaked during winter with higher abundances in the inner sector. The assemblage dynamics match the seasonal and spatial changes in the environmental conditions of the estuary. Descriptive variables explained 49.5% of the polychaetes variance according to Redundancy Analysis. Rainfall, temperature and salinity were the variables most influencing the assemblage, with rainfall and temperature regulating seasonal, and mostly salinity regulating spatial patterns, similar to meroplanktonic populations from both temperate and tropical latitudes. Dominant species had different hydrographic preferences,Loimiasp. was more abundant in warmer (>23°C) and saltier (>25) waters,Magelona papillicornislarvae were more abundant in saltier waters with intermediate temperatures (22–23°C), and the syllids were more common and abundant on lower temperatures (<20°C). In addition we highlight the occurrence of several benthic taxa suspended in the water column, probably due to bottom disturbance.
Tracing ancient evolutionary divergence in parasites
Authors: TINSLEY RICHARD C. , TINSLEY MATTHEW C.
Published: August 2016

For parasitic platyhelminths that generally lack a fossil record, there is little information on the pathways of morphological change during evolution. Polystomatid monogeneans are notable for their evolutionary diversification, having originated from ancestors on fish and radiated in parallel with tetrapod vertebrates over more than 425 million years (My). This study focuses on the genusPolystomoidesthat occurs almost worldwide on freshwater chelonian reptiles. Morphometric data show a major divergence in structural adaptations for attachment; this correlates with a dichotomy in micro-environmental conditions in habitats within the hosts. Species infecting the urinary tract have attachment organs with large hamuli and small suckers; species in the oro-nasal tract differ fundamentally, having small hamuli and large suckers. Zoogeographical and molecular evidence supports ancient separation of these site-specific clades: a new genus is proposed –Uropolystomoides– containing urinary tract species distinct fromPolystomoides sensu strictoin oro-nasal sites. Aside from differences in attachment adaptations, body plans have probably changed little over perhaps 150 My. This case contrasts markedly with polystomatids in other vertebrate groups where major morphological changes have evolved over much shorter timescales; the chelonian parasites show highly stable morphology across their global distribution over a long period of evolution, exemplifying ‘living fossils’.
Thermodynamic properties of thermonuclear fuel in inertial confinement fusion
Authors: Brandon V. , Canaud B. , Temporal M. , Ramis R.
Published: August 2016

Hot-spot path in the thermodynamic space $({\rm \rho} R,T_{\rm i} )_{{\rm hs}} $ is investigated for direct-drive scaled-target family covering a huge interval of kinetic energy on both sides of kinetic threshold for ignition. Different peak implosion velocities and two initial aspect ratios have been considered. It is shown that hot spot follows almost the same path during deceleration up to stagnation whatever the target is. As attended, after stagnation, a clear distinction is done between non-, marginally-, or fully igniting targets. For the last, ionic temperature can reach very high values when the thermonuclear energy becomes very high.
Continuous mobility of mobile robots with a special ability for overcoming driving failure on rough terrain
Authors: Xu He , Gao X. Z. , Xu Yan , Wang Kaifeng , Yu Hongpeng , Li Zhen , Alipour Khalil , Ani Ozoemena Anthony
Published: August 2016

For wheeled mobile robots moving in rough terrains or uncertain environments, driving failure will be encountered when trafficability failure occurs. Continuous mobility of mobile robots with special ability for overcoming driving failure on rough terrain has rarely been considered. This study was conducted using a four-wheel-steering and four-wheel-driving mobile robot equipped with a binocular visual system. First, quasi-static force analysis is carried out to understand the effects of different driving-failure modes on the mobile robot while moving on rough terrain. Secondly, to make the best of the rest of the driving force, robot configuration transformation is employed to select the optimal configuration that can overcome the driving failure. Thirdly, sliding mode control based on back-stepping is adopted to enable the robot achieve continuous trajectory tracking with visual feedback. Finally, the efficacy of the presented approach is verified by simulations and experiments.
Referential vs. non-referential null subjects in Middle Norwegian
Authors: Kinn Kari
Published: August 2016

This paper investigates the relationship between referential and non-referential null subjects in Middle Norwegian. It argues that overt, non-referential subjectdetarose before the loss of referential null subjects, contrary to the predictions of much previous work. A diachronic analysis compatible with the empirical findings is sketched out.
Initial views from the Digital Panopticon: Reconstructing Penal Outcomes in the 1790s
Authors: Ward Richard , Williams Lucy
Published: August 2016

The criminal justice system of eighteenth- and nineteenth-century England has been likened to a corridor of connected rooms or stage sets. At each stage in the judicial process—from detection and apprehension through to trial, sentencing, and punishment—decisions were made that might remove the accused from the system entirely, or propel that person further along the process into a number of possible outcomes. That decision making (including the identity of the decision makers and the criteria upon which their decisions were based) has been the subject of much historical study. Less attention has been given to the individual experiences—the singular journeys—of the accused through this labyrinthine process. This is in large part because of the inherent evidential and methodological difficulties of reconstructing judicial pathways and the wider criminal lives of offenders. As Tim Hitchcock and Robert Shoemaker note, the archives of criminal justice were created to manage the bureaucracy of prosecution and punishment, not to reveal the criminal's navigation of that system. Tracing an individual offender's journey through the judicial process (and that person's life beyond) therefore entails piecing together fragments spread almost randomly across hundreds of thousands of pages.
Mass Opinion and Immigration Policy in the United States: Re-Assessing Clientelist and Elitist Perspectives
Authors: Levy Morris , Wright Matthew , Citrin Jack
Published: August 2016

We argue that widely accepted elitist and “clientelist” models of immigration policy in the United States unduly minimize popular pressure on policy-making. These models portray majority opinion in ways that fail to recognize divergence between the public’s abstract goals for immigration policy and its support for the concrete policy changes needed to achieve them. As a result, they obscure many important instances in which immigration policy accords with public preferences despite counter-pressure from elites and organized lobbies. We demonstrate this point by identifying and explaining gaps between generalized attitudes and beliefs about specific policies in the domains of both legal and illegal immigration, showing that status quo legal admissions policies are not starkly at odds with majority preferences and that, contrary to interpretations of most commercial polling on the topic, majorities reject specific aspects of legalization programs that organized lobbies insist on as components of a “grand bargain” to overhaul an immigration system widely viewed as “broken.” Appreciating the nuance in mass opinion toward immigration policy helps explain policy stagnation that confounds elitist models and suggests that forging ahead with immigration reform will require persuading the public and not only successful bargaining among elites and interest groups.
The Koch Network and Republican Party Extremism
Authors: Skocpol Theda , Hertel-Fernandez Alexander
Published: August 2016

Presidential election years attract attention to the rhetoric, personalities, and agendas of contending White House aspirants, but these headlines do not reflect the ongoing political shifts that will confront whoever moves into the White House in 2017. Earthquakes and erosions have remade the U.S. political terrain, reconfiguring the ground on which politicians and social groups must maneuver, and it is important to make sure that narrow and short-term analyses do not blind us to this shifting terrain. We draw from research on changes since 2000 in the organizational universes surrounding the Republican and Democratic parties to highlight a major emergent force in U.S. politics: the recently expanded “Koch network” that coordinates big money funders, idea producers, issue advocates, and innovative constituency-building efforts in an ongoing effort to pull the Republican Party and agendas of U.S. politics sharply to the right. We review the major components and evolution of the Koch network and explore how it has reshaped American politics and policy agendas, focusing especially on implications for right-tilted partisan polarization and rising economic inequality.
Recruitment by Petition: American Antislavery, French Protestantism, English Suppression
Authors: Carpenter Daniel
Published: August 2016

Why do petitions flourish when they are often denied if not ignored by the sovereigns who receive them? When activists seek to build political organizations in network-rich but information-poor environments, petitioning as institutional technology facilitates recruitment. A petition’s signatory list identifies and locates individuals sympathetic to its prayer and expresses to other citizens who and how many agree with the prayer. Three historical moments—the explosion of antislavery petitioning in the antebellum United States, the emergence of Protestantism in sixteenth-century France, and England’s suppression of petitioning after the Restoration Settlement of 1660—provide vivid demonstrations of the theory. A recruitment-based theory implies that petition drives mobilize as much as they express, that well-established groups and parties petition less frequently, and that the most important readers of a petition are those asked to sign it. The petition’s recruitment function complements, but also transforms, its function of messaging the sovereign. Contemporary digital petitioning both routinizes and takes its force from the petition’s embedded recruitment technology.
Voter Mobilization, Experimentation, and Translational Social Science
Authors: Green Donald P. , Gerber Alan S.
Published: August 2016

Field experiments on voter mobilization enable researchers to test theoretical propositions while at the same time addressing practical questions that confront campaigns. This confluence of interests has led to increasing collaboration between researchers and campaign organizations, which in turn has produced a rapid accumulation of experiments on voting. This new evidence base makes possible translational works such asGet Out the Vote: How to Increase Voter Turnoutthat synthesize the burgeoning research literature and convey its conclusions to campaign practitioners. However, as political groups develop their own in-house capacity to conduct experiments whose results remain proprietary and may be reported selectively, the accumulation of an unbiased, public knowledge base is threatened. We discuss these challenges and the ways in which research that focuses on practical concerns may nonetheless speak to enduring theoretical questions.
A Discussion of Stephen Macedo’s Just Married: Same-Sex Couples, Monogamy and the Future of Marriage
Authors: Barclay Scott
Published: August 2016

On June 26, 2015, the U.S. Supreme Court ruled, in Obergefell v. Hodges, that the Fourteenth Amendment of the U.S. Constitution forbids legal discrimination against same-sex marriage. The decision sent shock waves throughout the country, with both supporters and opponents regarding it as signal of dramatic shifts in public opinion and a revolutionary development on the road to sex-gender equality. Just two days earlier, on June 24, 2015, Stephen Macedo’s Just Married: Same-Sex Couples, Monogamy, and the Future of Marriage was published. Macedo has always worked at the intersection of legal theory, normative theory, and public policy, and Just Married offers a nuanced liberal democratic defense of marriage equality with striking resonance in light of Obergefell. We have thus invited a range of scholars on LGBT rights, and LGBT politics more generally, to comment on his book.
A Discussion of Richard Flacks and Nelson Lichtenstein's The Port Huron Statement: Sources and Legacies of the New Left’s Founding Manifesto
Authors: Ackelsberg Martha , Shanley Mary L.
Published: August 2016

The Port Huron Statement was one of the most important manifestos of the New Left in the United States. A foundational statement of the theme of “participatory democracy,” the text had an important influence on post-1960s politics and, arguably, on post-1960s political science. The recent publication of a new edition of the Statement is an occasion for reflection on its importance. And so we have invited a distinguished cast of political scientists shaped by the events of the sixties to comment on the impact of the Statement on their own way of envisioning and practicing political science.
A Discussion of Richard Flacks and Nelson Lichtenstein's The Port Huron Statement: Sources and Legacies of the New Left’s Founding Manifesto
Authors: Connolly William E.
Published: August 2016

The Port Huron Statement was one of the most important manifestos of the New Left in the United States. A foundational statement of the theme of “participatory democracy,” the text had an important influence on post-1960s politics and, arguably, on post-1960s political science. The recent publication of a new edition of the Statement is an occasion for reflection on its importance. And so we have invited a distinguished cast of political scientists shaped by the events of the sixties to comment on the impact of the Statement on their own way of envisioning and practicing political science.
Naming Rites for Naming Wrongs: What We Talk about When We Talk about Woodrow Wilson
Authors: Strolovitch Dara Z. , Crowder Chaya Y.
Published: August 2016

Woodrow Wilson is the only American political scientist to have served as President of the United States. In the time between his political science Ph.D. (from Johns Hopkins, in 1886) and his tenure as president (1913–21), he also served as president of Princeton University (1902–10) and president of the American Political Science Association (1909–10). Wilson is one of the most revered figures in American political thought and in American political science. The Woodrow Wilson Award is perhaps APSA’s most distinguished award, given annually for the best book on government, politics, or international affairs published in the previous year, and sponsored by the Woodrow Wilson Foundation at Princeton University.

Wilson has also recently become the subject of controversy, on the campus of Princeton University, and in the political culture more generally, in connection with racist statements that he made and the segregationist practices of his administration. A group of Princeton students associated with the “Black Lives Matter” movement has demanded that Wilson’s name be removed from two campus buildings, one of which is the famous Woodrow Wilson School of Public and International Affairs (see Martha A. Sandweiss, “Woodrow Wilson, Princeton, and the Complex Landscape of Race,”http://www.thenation.com/article/woodrow-wilson-princeton-and-the-complex-landscape-of-race/). Many others have resisted this idea, noting that Wilson is indeed an important figure in the history of twentieth-century liberalism and Progressivism in the United States.

A number of colleagues have contacted me suggesting thatPerspectivesought to organize a symposium on the Wilson controversy. Although we do not regularly organize symposia around current events, given the valence of the controversy and its connection to issues we have featured in our journal (see especially the September 2015 issue on “The American Politics of Policing and Incarceration”), and given Wilson's importance in the history of our discipline, we have decided to make an exception in this case. We have thus invited a wide range of colleagues whose views on this issue will interest our readers to comment on this controversy. —Jeffrey C. Isaac, Editor.
Education and Transparency: Changes in Campus Iconography
Authors: Pinderhughes Dianne
Published: August 2016

Woodrow Wilson is the only American political scientist to have served as President of the United States. In the time between his political science Ph.D. (from Johns Hopkins, in 1886) and his tenure as president (1913–21), he also served as president of Princeton University (1902–10) and president of the American Political Science Association (1909–10). Wilson is one of the most revered figures in American political thought and in American political science. The Woodrow Wilson Award is perhaps APSA’s most distinguished award, given annually for the best book on government, politics, or international affairs published in the previous year, and sponsored by the Woodrow Wilson Foundation at Princeton University.

Wilson has also recently become the subject of controversy, on the campus of Princeton University, and in the political culture more generally, in connection with racist statements that he made and the segregationist practices of his administration. A group of Princeton students associated with the “Black Lives Matter” movement has demanded that Wilson’s name be removed from two campus buildings, one of which is the famous Woodrow Wilson School of Public and International Affairs (see Martha A. Sandweiss, “Woodrow Wilson, Princeton, and the Complex Landscape of Race,” http://www.thenation.com/article/woodrow-wilson-princeton-and-the-complex-landscape-of-race/). Many others have resisted this idea, noting that Wilson is indeed an important figure in the history of twentieth-century liberalism and Progressivism in the United States.

A number of colleagues have contacted me suggesting that Perspectives ought to organize a symposium on the Wilson controversy. Although we do not regularly organize symposia around current events, given the valence of the controversy and its connection to issues we have featured in our journal (see especially the September 2015 issue on “The American Politics of Policing and Incarceration”), and given Wilson's importance in the history of our discipline, we have decided to make an exception in this case. We have thus invited a wide range of colleagues whose views on this issue will interest our readers to comment on this controversy. —Jeffrey C. Isaac, Editor.
Transforming Silence into an Active, Present Awareness: What to do about Wilson’s Legacy
Authors: Shaw Todd
Published: August 2016

Woodrow Wilson is the only American political scientist to have served as President of the United States. In the time between his political science Ph.D. (from Johns Hopkins, in 1886) and his tenure as president (1913–21), he also served as president of Princeton University (1902–10) and president of the American Political Science Association (1909–10). Wilson is one of the most revered figures in American political thought and in American political science. The Woodrow Wilson Award is perhaps APSA’s most distinguished award, given annually for the best book on government, politics, or international affairs published in the previous year, and sponsored by the Woodrow Wilson Foundation at Princeton University.

Wilson has also recently become the subject of controversy, on the campus of Princeton University, and in the political culture more generally, in connection with racist statements that he made and the segregationist practices of his administration. A group of Princeton students associated with the “Black Lives Matter” movement has demanded that Wilson’s name be removed from two campus buildings, one of which is the famous Woodrow Wilson School of Public and International Affairs (see Martha A. Sandweiss, “Woodrow Wilson, Princeton, and the Complex Landscape of Race,” http://www.thenation.com/article/woodrow-wilson-princeton-and-the-complex-landscape-of-race/). Many others have resisted this idea, noting that Wilson is indeed an important figure in the history of twentieth-century liberalism and Progressivism in the United States.

A number of colleagues have contacted me suggesting that Perspectives ought to organize a symposium on the Wilson controversy. Although we do not regularly organize symposia around current events, given the valence of the controversy and its connection to issues we have featured in our journal (see especially the September 2015 issue on “The American Politics of Policing and Incarceration”), and given Wilson's importance in the history of our discipline, we have decided to make an exception in this case. We have thus invited a wide range of colleagues whose views on this issue will interest our readers to comment on this controversy. —Jeffrey C. Isaac, Editor.
Municipal solid waste composting: Application as a tomato fertilizer and its effect on crop yield, fruit quality and phenolic content
Authors: Ribas-Agustí Albert , Seda Marta , Sarraga Carmen , Montero Juan I. , Castellari Massimo , Muñoz Pere
Published: August 2016

Composting is an appealing way to reutilize the organic fraction of municipal solid waste (MSW). Beyond the obvious advantage of reducing urban waste, the use of MSW compost in agriculture entails other potential benefits, such as reducing the amount of mineral fertilizer applied to the field and providing a potentially higher quality alternative. However, some concerns may arise from its use, such as crop yield and quality alterations. This work studied the effect of fertilizing with compost obtained from the organic fraction of MSW, on crop yield, crop quality and phenolic content of tomato fruit. Experiments were conducted in the Barcelona area, usingSolanum lycopersicumL., var. ‘Penjar’, a popular regional tomato. Compared with the use of mineral fertilizer (M), fertilization with MSW compost alone (C) or combined with mineral fertilizer (C + M) had no significant effect on tomato fruit quality characterized by weight, diameter or Brix, nor was there a significant effect on total phenolic content. In contrast, the C treatment altered the phenolic profile by enhancing a kaempferol derivative, and caused a 43 and 48% yield reduction compared with the C + M and M treatments, respectively. Overall, composted MSW + mineral fertilizer appeared to be the best strategy for the reutilization of MSW in tomato culture, as it did not compromise crop yield or fruit quality.
Gender and Causal Concepts: Implications for Comparative Theory Building
Authors: Mazur Amy , Spierings Niels
Published: August 2016

Clear conceptualization should be at the core of every comparative study. Gender scholars have a long history of challenging the public/private divide in conventional notions of the political and laying bare the gendered or androcentric character of established concepts such as welfare states (Sainsbury 2008), war (Goldstein 2001), work (Spierings 2015), or democracy (Paxton 2008; Walby 2009). This criticism often focuses on descriptive and normative meanings (see Goertz 2006, 3). It is descriptive where concepts seek to describe units of analysis such as countries and their levels of democracy and normative because the criticism shows how concepts legitimize androcentric practices. Comparative scholars, however, tend to go one step beyond descriptive comparisons; we seek to explain cross-national variation—for example, why certain countries are democratic, why certain welfare state policies are implemented, or why war occurs. This relates to the relatively new notions of “causal concepts” (Goertz 2006) and the “causal relationship guideline” (Goertz and Mazur 2008).
Homage to the ‘H’ in developmental origins of health and disease
Authors: Rosenfeld C. S.
Published: August 2016

Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.
An Overview of Sri Lanka’s Bilateral Investment Treaties: Status Quo and Some Insights into Future Modifications
Authors: PATHIRANA Dilini
Published: August 2016

Sri Lanka is the first country against which a foreign investor has had recourse to international arbitration based on the dispute settlement clause in a bilateral investment treaty (BIT). This was the case ofAAPL v. Sri Lanka.Since then, the country has been challenged twice before the International Centre for Settlement of Investment Disputes (ICSID), while its latest encounter was in the case ofDeutsche Bank AG v. Sri Lanka. In the intervening years between these two cases, Sri Lanka maintained silence and failed to alter its BITs in a global context where the conventional attitude on international investment agreements (IIAs) is being increasingly reconsidered. This paper provides an overview of Sri Lanka’s BITs, which highlights the urgency of reconsidering the country’s investment treaty-making practice. It suggests some modifications to align the country’s investment treaty-making practice with international investment law (IIL) developments.
Commodity Flows, Diaspora Networking, and Contested Agency in the Eastern Indian Ocean c. 1000–1500
Authors: Hall Kenneth R.
Published: August 2016

Recent revisionist approaches to early pre-1500 eastern Indian Ocean history draw from and cross-reference epigraphic, archaeological, art historical, literary, cultural, textual, shipwreck, and a variety of other primary and secondary sources as these document the evolution of Southeast Asia from roughly 300 to 1500, before significant European regional presence became a factor. This study's focus is the transitional importance of c. 1000–1500 Indian Ocean international maritime trade and transit from the South Asian shorelines of the Bay of Bengal to the South China and Java Seas, which is conceived to have temporarily produced an inclusive eastern Indian Ocean zone of contact. In this then ‘borderless’ region there were a variety of meaningful contacts and material, cultural, and knowledge transfers that resulted in synthesis of Indian, Chinese, Middle Eastern, and Southeast Asian cultures and populations made possible by enhanced international maritime trade connections before European presence became a factor, a period often dated from the fall of Melaka to the Portuguese in 1511.
T‐cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases
Authors: McKinney Eoin F , Smith Kenneth GC
Published: August 2016

During acute viral infection CD8 T cells rapidly expand before contracting down to a persistent memory population that confers long‐lasting immunity. However when the antigen persists, such as during chronic viral infection, a dysfunctional process termed ‘exhaustion’ limits the antiviral response, facilitating ongoing viraemia and poor clinical outcome. CD8 T‐cell exhaustion was originally identified in lymphocytic choriomeningitis virus infection of mice; however, new evidence has shown that exhaustion is associated with the control of a wide range of human chronic inflammatory states, including chronic viral infection, autoimmunity and cancer. Consequently, an understanding of the mechanisms controlling exhaustion during chronic infection may also indicate new strategies for controlling other chronic inflammatory diseases. In particular, the success of immune checkpoint blockade as a form of cancer immunotherapy has prompted renewed efforts to understand how T‐cell immunity to chronic antigenic stimulation might similarly be measured or modulated in autoimmune diseases. Here we summarise the mechanisms controlling T‐cell exhaustion and how they relate to the control of autoimmune responses, providing a future perspective on measuring or manipulating exhaustion to personalise therapy.
Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain
Authors: Wang Yu-Chuan , Chin Ko-Hsin , Tu Zhi-Le , He Jin , Jones Christopher J. , Sanchez David Zamorano , Yildiz Fitnat H. , Galperin Michael Y. , Chou Shan-Ho
Published: August 2016

C-di-GMP is a bacterial second messenger regulating various cellular functions. Many bacteria contain c-di-GMP-metabolizing enzymes but lack known c-di-GMP receptors. Recently, two MshE-type ATPases associated with bacterial type II secretion system and type IV pilus formation were shown to specifically bind c-di-GMP. Here we report crystal structure of the MshE N-terminal domain (MshEN1-145) from Vibrio cholerae in complex with c-di-GMP at a 1.37 Å resolution. This structure reveals a unique c-di-GMP-binding mode, featuring a tandem array of two highly conserved binding motifs, each comprising a 24-residue sequence RLGxx(L/V/I)(L/V/I)xxG(L/V/I)(L/V/I)xxxxLxxxLxxQ that binds half of the c-di-GMP molecule, primarily through hydrophobic interactions. Mutating these highly conserved residues markedly reduces c-di-GMP binding and biofilm formation by V. cholerae. This c-di-GMP-binding motif is present in diverse bacterial proteins exhibiting binding affinities ranging from 0.5 μM to as low as 14 nM. The MshEN domain contains the longest nucleotide-binding motif reported to date.
TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma
Authors: Jung Joonil , Lee Joon Sang , Dickson Mark A. , Schwartz Gary K. , Le Cesne Axel , Varga Andrea , Bahleda Rastilav , Wagner Andrew J. , Choy Edwin , de Jonge Maja J. , Light Madelyn , Rowley Steve , Macé Sandrine , Watters James
Published: August 2016

In tumours that harbour wild-type p53, p53 protein function is frequently disabled by the mouse double minute 2 protein (MDM2, or HDM2 in humans). Multiple HDM2 antagonists are currently in clinical development. Preclinical data indicate that TP53 mutations are a possible mechanism of acquired resistance to HDM2 inhibition; however, this resistance mechanism has not been reported in patients. Utilizing liquid biopsies, here we demonstrate that TP53 mutations appear in circulating cell-free DNA obtained from patients with de-differentiated liposarcoma being treated with an inhibitor of the HDM2–p53 interaction (SAR405838). TP53 mutation burden increases over time and correlates with change in tumour size, likely representing selection of TP53 mutant clones resistant to HDM2 inhibition. These results provide the first clinical demonstration of the emergence of TP53 mutations in response to an HDM2 antagonist and have significant implications for the clinical development of this class of molecules.
Large polarization-dependent exciton optical Stark effect in lead iodide perovskites
Authors: Yang Ye , Yang Mengjin , Zhu Kai , Johnson Justin C. , Berry Joseph J. , van de Lagemaat Jao , Beard Matthew C.
Published: August 2016

A strong interaction of a semiconductor with a below-bandgap laser pulse causes a blue-shift of the bandgap transition energy, known as the optical Stark effect. The energy shift persists only during the pulse duration with an instantaneous response time. The optical Stark effect has practical relevance for applications, including quantum information processing and communication, and passively mode-locked femtosecond lasers. Here we demonstrate that solution-processable lead-halide perovskites exhibit a large optical Stark effect that is easily resolved at room temperature resulting from the sharp excitonic feature near the bandedge. We also demonstrate that a polarized pump pulse selectively shifts one spin state producing a spin splitting of the degenerate excitonic states. Such selective spin manipulation is an important prerequisite for spintronic applications. Our result implies that such hybrid semiconductors may have great potential for optoelectronic applications beyond photovoltaics.
Refuting the hypothesis that the acquisition of germ plasm accelerates animal evolution
Authors: Whittle Carrie A. , Extavour Cassandra G.
Published: August 2016

Primordial germ cells (PGCs) give rise to the germ line in animals. PGCs are specified during embryogenesis either by an ancestral mechanism of cell–cell signalling (induction) or by a derived mechanism of maternally provided germ plasm (preformation). Recently, a hypothesis was set forth purporting that germ plasm liberates selective constraint and accelerates an organism’s protein sequence evolution, especially for genes from early developmental stages, thereby leading to animal species radiations; empirical validation has been claimed in vertebrates. Here we present findings from global rates of protein evolution in vertebrates and invertebrates refuting this hypothesis. Contrary to assertions of the hypothesis, we find no effect of preformation on protein sequence evolution, the evolutionary rates of early-stage developmental genes, or on species diversification. We conclude that the hypothesis is mechanistically implausible, and our multi-faceted analysis shows no empirical support for any of its predictions.