bluuebunny/crossref_metadata_2025 huggingface dataset:
Metodologia da pesquisa em competência em informação
Authors: Silva Carlos Robson Souza da , Teixeira Thiciane Mary Carvalho , Pinto Virginia Bentes
Published: December 2019

As pesquisas relacionadas à temática levaram à proliferação de modelos de Competência em Informação, utilizados como quadro de referência, para aplicação em outras pesquisas ou na prática bibliotecária. Tendo isso em vista, questiona-se: quais foram os modelos de Competência em Informação utilizados como quadro de referência em dissertações e teses defendidas em Programas de Pós-Graduação em Ciência da Informação, no período de 2014 a 2018? O presente trabalho tem como objetivo geral: identificar os modelos de Competência em Informação utilizados com mais frequência na pesquisa sobre Competência em Informação no Brasil. E como objetivos específicos: a) apresentar um panorama da pesquisa brasileira sobre Competência em Informação; b) apresentar as principais tendências na produção de teses e dissertações sobre Competência em Informação no Brasil; c) realizar uma revisão sistemática da pesquisa brasileira em nível de Mestrado e Doutorado em Ciência da Informação entre 2014-2018.  Trata-se de uma pesquisa exploratória, de abordagem qualitativa, que utiliza como método de pesquisa bibliográfica a revisão sistemática dos resultados obtidos em levantamento realizado na Biblioteca Digital de Teses e Dissertações (BDTD) do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT). Conclui apontando para o fato de que os modelos de Competência em Informação são tidos como essenciais para o desenvolvimento da pesquisa sobre a temática e servem como fundamentação teórica e metodológica para a crítica, a interpretação e aplicação de conceitos e métodos sobre Competência em Informação.
Efeitos de sentidos de “palavras de amizade e boa vontade”
Authors: Tinoco João Paulo Machado , Guerra Vania Maria Lescano
Published: December 2019

Propomo-nos estudar o processo da constituição identitária do sujeito indígena como articulado na Carta do Cacique Seattle (1854), a fim de apreender os efeitos de sentidos de intolerância e preconceito. Para tal, faz-se necessário a crítica do estudo das relações de saber/poder (FOUCAULT, 2014), da perspectiva discursivo-desconstrutiva de Guerra (2017) e da concepção de lugar Geoistórico de Nolasco (2013). Nossa hipótese de pesquisa é que a Carta, examinada como um monumento, possibilita-nos a exumação de histórias locais e memórias veladas, silenciadas pelo saber hegemônico. A análise nos permite dizer que o indígena não se enquadra ao que é esperado pelo “homem branco” em relação à terra e a maneira de viver, em consequência, os saberes aos quais o povo indígena está atrelado são desqualificados.
A violência urbana nas narrativas de telejornais e a construção do inimigo
Authors: Oliveira Graziele Rodrigues de
Published: December 2019

O artigo reflete sobre o legado colonialista no Brasil e o apagamento das questões sociais nas narrativas de telejornais sobre violência urbana. No Brasil a criminalidade é tratada pelo Estado de forma emergencial e se revela como artifício para o controle social e punição aos mais pobres (FOUCAULT, [1987] 2009). Para tanto, foram selecionados dois materiais de telejornais da Rede Globo sobre arrastões em áreas nobres da cidade do Rio de Janeiro. A metodologia de análise consiste na intersecção entre a perspectiva bourdiana e foucaultiana, com base na ideia de que a reprodução do discurso dominante no tempo-espaço naturaliza o problema da marginalização social. As considerações finais desta análise apontam para a atuação dos telejornais na promoção do ódio e na construção do Outro como inimigo.
Deriva, cartografia e intervenção
Authors: Hirao Hélio , Chaparim Matheus Alcântara Silva
Published: December 2019

O artigo aborda a prática da deriva situacionista e a produção de cartografias psicogeográficas como procedimentos metodológicos para o reconhecimento, intervenção e preservação do Patrimônio Urbano e Arquitetônico de uma pequena cidade do interior do oeste paulista, Regente Feijó. Relata-se uma experiência de ensino desenvolvida com alunos do quarto ano de arquitetura e urbanismo da UNESP, em 2017, na qual as possibilidades de intervenção projetual ocorreram simultaneamente com a experimentação das ambiências e atmosferas do centro histórico estudado. Assim, essa abordagem evidencia outro olhar para a preservação patrimonial, ao ativar e potencializar as práticas espaciais existentes e estimular que novas apropriações apareçam.
Por uma teoria do sujeito intervalar na experiência com a tela escura
Authors: Venera José Isaías
Published: December 2019

Neste artigo, desenvolve-se a noção de sujeito intervalar a partir das experiências contemporâneas com os dispositivos móveis de acesso à internet. A investigação inicia com uma imagem que circulou nas redes sociais da internet durante os protestos de junho de 2013, por meio da qual são feitas relações, sobretudo, com outras duas imagens de dois períodos históricos, sendo uma analisada por Michel Foucault (1999) e outra por Gilles Deleuze (2007). O modo como Foucault e Deleuze se apropriam de obras de arte para investigar a formação de novos campos de visibilidade permite também a análise sobre a emergência de uma outra relação com as imagens e com a qual é desenvolvida a noção de sujeito intervalar.
Narrativas na cidade em álbuns fotográficos
Authors: Silva Cristina Maria da , Braga Francisco Felipe Pinto
Published: December 2019

Abordamos as narrativas sobre o Poço da Draga na cidade de Fortaleza-CE a partir de álbuns fotográficos. Partimos das discussões de Certeau (2009); Gagnebin (2006); Assmann (2011) e Bruno (2013; 2014). O Grupo de Estudos e Pesquisas Rastros Urbanos por meio do projeto de extensão “Fotobiografias: a Fortaleza que se Encontra em Acervos Fotográficos Pessoais”, desenvolve trabalhos que objetivam mostrar e socializar essas outras narrativas sobre a cidade. O Poço da Draga está localizado em uma área de grande especulação imobiliária próxima à praia de Iracema, e sofre constantemente com a pressão do poder público e privado para que seus habitantes sejam removidos. Por meio de visitas aos habitantes desse lugar, escutamos suas histórias e conhecemos suas memórias. As fotografias nos permitem conhecer essas biografias individuais e relacioná-las com a biografia coletiva da cidade, repensando as reflexões sobre antropologia urbana, bem como abrem um espaço vivo e potente para uma ação de extensão universitária.
Espaço urbano e subversão queer
Authors: Pagnan Redson
Published: December 2019

Neste artigo, pretendo discutir as relações estabelecidas entre gênero, sexualidade e espaço urbano, a partir da prática discursiva intersemiótica de Linn da Quebrada. Pretendo, também, refletir sobre os lugares de resistência que corpos considerados desviantes ocupam subvertendo o valor inicial do espaço urbano, ou seja, ressignificando um status arquitetônico/urbanístico. Assim, fugindo dos padrões naturalizados de gênero e sexualidade passam a viver uma experiência diferente nas cidades, entre centro e periferia, entre lugares e não-lugares, reinventando a cidade com características que ela nunca teve ou jamais imaginou ter. Para esta análise, utilizo um recorte do corpus de minha pesquisa: a canção “Bomba pra Caralho” – como exemplar de produção discursiva do espaço canônico musical (cf. MAINGUENEAU, 2006). Na análise, utilizo o arcabouço teórico e metodológico da Análise do Discurso de linha francesa; reflexões sobre a relação entre o corpo e a cidade vindas da filosofia, sociologia e da arquitetura; além de pressupostos das teorias Queer, para pensar gênero e sexualidade para além da perspectiva dos binarismos, historicamente e discursivamente construídos, que orientam (performam) as práticas dos sujeitos, inclusive no campo da arquitetura e urbanismo.
REVOLUSI MENTAL ALA NABI KHIDIR TERHADAP NABI MUSA
Authors: Syauqani Syamsu
Published: December 2019

Indonesia is currently being hit by a multi-dimensional crisis ranging from economic, moral, to a crisis of self-confidence. Indonesia filters that can fortify its people and even become a soft field for the spread of moral viruses, including drugs, pornography, and value-free media. So President Joko Widodo sparked a term of the mental revolution in 2014. Mental revolution as a movement of change is concerned with the mind, attitude, and character that occurs in humans. This mental revolution aims to change human attitudes and character. Therefore, the perfection of this Qur'anic guidance becomes a reference to be used as a solution in every dynamic of human problems including mental revolution. In this research, the story of the Prophet Khidir and Musa was one of the models in applying the mental revolution.
Microbiological Methods to Detect Intestinal Carriage of Highly-resistant Microorganisms (HRMO) in Humans and Livestock in the i-4-1-Health Dutch-Belgian Cross-border Project
Authors: Kluytmans-van den Bergh Marjolein , Lammens Christine , Perales Selva Natascha , Verhulst Carlo , Buiting Anton , Leroux-Roels Isabel , Saegeman Veroniek , Savelkoul Paul , Schuermans Annette , Veenemans Jacobien , van der Vegt Dewi , Willemsen Ina , Wintermans Bas , Goossens Herman , Kluytmans Jan
Published: December 2019

The i-4-1-Health project is a One Health project on the prevalence and spread of antimicrobial resistance in the human and veterinary domain in the Dutch-Belgian cross-border region. This paper describes the main components of the laboratory protocol that was developed to standardise the microbiological methods used for the detection of intestinal carriage of highly-resistant microorganisms.
Jodoh di Ujung Jempol: Tinder sebagai Ruang Jejaring Baru
Authors: Kusumaningtyas Amelinda Pandu , Hakim Azinuddin Ikram
Published: December 2019

Tinder has become part of youth life in Indonesia and challenging the conventional and traditional way of courtship. The increasing of communication technology has an impact to change the way we communicate each other, a lifestyle, and a values in romance relationship. Tinder is one of products from the technology of media in the network societies. This case study research was conducted to understand how Tinder change Indonesian youth’s courtship experience. We interviewed 3 young Tinder users from different background with diverse experience. Through this study we found five interesting findings: (1) Tinder has contributed to the decrease of parents role in courtship, (2) Tinder has simplified the conceptnof relationship, (3) Ttinder is a safe space for marginalized youth to express themselves, (4) Tinder is a part of arena for network society, and (5) Tinder is surrounded with various stigma from general public.
The Dissemination of Multidrug Resistance (MDR) and Extensively Drug Resistant (XDR) among Uropathogenic E. coli (UPEC) Isolates from Urinary Tract Infection Patients in Babylon Province, Iraq
Authors: Et al. Al-Hasnawy
Published: December 2019

Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. So, the growth of Uropathgenic Escherichia coli (UPEC) isolates with Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) profiles that thwart therapy for (UTIs) has been detected and has straight squeezed costs and extended hospital stays. This study aims to detect MDR- and XDR-UPEC isolates. Out of 42 UPEC clinical isolates were composed from UTI patients. The bacterial strains were recognized by standard laboratory protocols. Susceptibility to antibiotic was measured by the standard disk diffusion method Out of 42 Uropathogenic E. coli, 37 (88.09%) were found to be MDR while 5 isolates (11.90%) were XDR. The present study concluded high prevalence of uropathogenic Escherichia coli (UPEC) with Multidrug-resistant (MDR) isolated from urinary tract infection in Babylon province – Iraq.
Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives
Authors: Et al. Khammas
Published: December 2019

Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound  ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4), Reaction of 5-(P-dimethyl amine benzene)-2-amino-1,3,4- oxadiazole in the presence of potassium carbonate anhydrous to yield new  compound (N-(2- aminoacetyl-5-(P-dimethyl amine benzene )-1,3,4-oxadiazoles-2-yl)(A30) and Azo compound (N-(5-(Azo-2-hydroxy-5-amino benzene)-1,3-Diazol-2yl)Allopurinol(A46). The structure of prepared compounds were confirmed by (FT-IR) technique and their physical properties. The synthesized compounds were tested for cytotoxicity, Xanthine oxidase inhibition, and antioxidant activity.
Spectrophotometric Determination of Mesalazine in Pharmaceutical Preparations by Oxidative Coupling Reactions with m-Aminophenol and 2,6- Dihydroxybenzoic Acid
Authors: Et al. Aziz
Published: December 2019

Tow simple, rapid and sensitive spectrophotometric methods for the determination of mesalazine in pharmaceutical preparations have been carried out. The proposed methods depend on oxidative coupling reaction of mesalazine with m-aminophenol in the existence of N-bromosuccinamide in alkaline medium (method A) and 2,6-dihydroxybenzoic acid in the existence of sodium metaperiodate in basic medium (method B) to produce colored products , show highest absorptions at 640 (nm) and 515 (nm), alternately. Beer’s law was consistent in concentrations extent of 1.25-30 and 0.5-12.5 (µg.mL-1) with molar absorptivity of 0.36×104 and 0.77×104 L.mol-1.cm-1, alternately. The limits of detection (LOD) were 0.0144 and 0.0829   µg.mL-1, while limits of quantitation (LOQ) were 0.0483 and 0.2766 (µg.mL-1), alternately. The suggested methods have been applied successfully to the determination of mesalazine in its pharmaceutical preparations as tablets and suppositories.
Effect of the Dielectric Barrier Discharge Plasma on the Optical Properties of CDS Thin Film
Authors: Jebur Eman Kadum
Published: December 2019

Cadmium sulphide CdS films with 200 nm have been prepared by thermal evaporation technique on glass substrate at substrate room temperature under vacuum of 10-5mbar.In this paper, the effect of Dielectric Barrier Discharge plasma on the optical properties of the CdS film. The prepared films were exposed to different time intervals (0, 3, 5, 8) min. For every sample, the Absorption A, absorption coefficient α , energy gap Eg ,extinction coefficient K and dielectric constant ε were studied. It is found that the energy gap were decreased with exposure time, and absorption , Absorption coefficient, refractive index, extinction coefficient,  dielectric constant increased with time of exposure to the plasma. Our study considers the first investigation of the effect of cold atmospheric plasma on the optical properties of CdS film.
Grado de microfiltración en sellantes dentales usados en premolares con dos tratamientos de superficie dental
Authors: Herrera-Cuadros SF , Albites-Achata U
Published: December 2019

OBJETIVO: Comparar in vitro el grado de microfiltración de los sellantes en premolares humanos con la técnica de aire abrasivo y ameloplastía como preparación de superficie. METODOLOGÍA: Se realizó un estudio in vitro en premolares humanos, se agruparon en 3 grupos de 25 piezas: Control, ameloplastía con fresa de fisura y aire abrasivo con partículas de aluminio de 110µm. Se realizó la preparación  de superficie de acuerdo al grupo y se aplicaron los sellantes dentales, se termociclaron 500 ciclos (5° y 55°C) por 30 segundos en las temperaturas mínima y máxima, posteriormente fueron sumergidos durante 24 horas en azul de metileno al 1%, seccionados bucolingualmente y evaluados en un estereomicroscopio a 16x. Se usó la prueba chi cuadrado a un nivel de significancia de 0.05.  RESULTADOS: En el grupo control se observó que 7 (28%) no filtraron, 9 (36%) filtraron menos de 500µm y 9 (36%) más de 500µm. En el grupo preparado con ameloplastía con fresa de fisura, 6(24%) no filtraron, 7 (28%) filtraron menos de 500µm, y 12 (48%) filtraron más de 500um. Finalmente, en la técnica con aire abrasivo, 3 (12%) no filtraron, 7 (28%) filtraron menos de 500µm, y 15 (60%) filtraron más de 500µm. No hubo asociación significativa p= 0.482 CONCLUSIÓN: El grado de microfiltración de sellantes en premolares no está asociado con la técnica de preparación de superficie, sin embargo se observó menor microfiltración en el grupo control seguido de ameloplastia y finalmente de aire abrasivo.
Efecto del tiempo de grabado con ácido fosfórico al 37.5% sobre la superficie de esmalte haciendo uso de agentes cementantes autoadhesivos.
Authors: Ascurra Francia Liliana , Saravia-Rojas M A
Published: December 2019

OBJETIVO: Comparar la resistencia traccional de resina compuesta adherida a la superficie del esmalte de bovino en diferentes intervalos de tiempos de 15 y 30 segundos haciendo uso de ácido grabador  en tres agentes cementantes autoadhesivos y un grupo control. MATERIALES Y MÉTODOS: Fueron utilizados treinta y cinco incisivos inferiores sanos de bovino menor de 3 años, los cuales fueron divididos aleatoriamente en siete grupos correspondientes a cada cemento autoadhesivo y tiempo de grabado ácido: RelyX U200 (3M) (grupo U15”) (grupo U30”), Bis Cem (BISCO)(grupo B15”)(grupo B30”), MaxCem Elite (KERR)(grupo M15”)(grupo M30”), RelyX Ultimate (3M)(grupo UL) se procedió a la cementación con los bloques de resina compuesta como se indica el protocolo previo grabado ácido del esmalte de 15 y 30 segundos para cada cemento . Los especímenes de 1 mm2 de área transversal (n = 30 por grupo) se almacenaron en agua destilada por 24 horas a 36 °C. La prueba de microtensión se realizó haciendo uso del Microtensile Tester (Bisco). Para el análisis estadístico se utilizaron las pruebas de Kruskal Wallis y U Mann Whitney (p<0.05). RESULTADOS: El grupo U 30” presentó una resistencia promedio de 24.82 (±3.80) MPa; el U 15”, 23.40 (±5.80 ) MPa, el M30”,30.86 (±9.85) MPa, el M15”, 28.29 (±2.02) MPa, el B 30”, 17.42(±3.49) MPa, el B15”,17.63 (±3.61) MPa, y el UL, 31.53 (±6.39 ) MPa, encontrando diferencia significativa entre ellos (p < 0.001) a través del análisis de Kruskal Wallis . CONCLUSIÓN: El cemento Relyx Ultimate obtuvo el valor más alto de resistencia traccional encontrándose diferencias estadísticamente significativas con todos cementos autoadhesivos. No se encontraron diferencias estadísticamente significativas al comparar los dos tiempos de grabado ácido de 15 y 30 seg. en esmalte entre los grupos de cementos autoadhesivos, al cabo de 24 horas.
Resistencia de unión entre dientes de bovino y cerámica feldespática utilizando tres cementos fotoactivados para carillas. Estudio in vitro
Authors: Quispe-Palomino S E , Saravia-Rojas M A , Saravia-Rojas M A
Published: December 2019

OBJETIVO: Comparar in vitro la resistencia de unión entre dientes de bovino y cerámica feldespática utilizando loscementos fotoactivados para carillas (Choisse II, Variolink N, Relyx Ultimate).MATERIALES Y MÉTODOS: El grupo de estudio estuvo conformado por 3 grupos; un grupo control y 2 gruposexperimentales distribuidos aleatoriamente y determinados mediante la fórmula para comparar promedios; con 120especímenes en total, n= 30 especímenes por grupo; se utilizaron tres agentes cementantes: Relyx Ultimate (3M ESPE),Choise II (BISCO), Variolink N (IVOCLAR). Con los agentes autoadhesivos se procedió a la cementación como indica elprotocolo para cada cemento. Los especímenes de 1 mm2 de área transversal, se obtuvieron con una máquina de cortestipo IsoMet y se almacenaron en agua destilada por 24 horas a 36 °C. La prueba de microtensión se realizó haciendouso del Microtensile Tester (Bisco). Para el análisis estadístico se utilizaron las pruebas de ANOVA y Tukey (p=0.05).RESULTADOS: El grupo Variolink N presentó una resistencia promedio de 18.42 ± 3,40 MPa; el Relyx Ultimate 18.42± 5,32 MPa, y el Choise II 11.92 ± 4,32 MPa, encontrando diferencia significativa entre ellos (p < 0.001) a través delanálisis de ANOVA.CONCLUSIÓN: No existe diferencia significativa ente los cementos Variolink N y Relyx Ultimate, pero ambos fueronsuperiores significativamente al cemento Choisse II al cabo de 24 horas.
Resistencia a la flexión de resinas acrílicas termopolimerizables usadas en la fabricación de prótesis totales
Authors: Martínez-Huacho N. C.
Published: December 2019

OBJETIVO: Evaluar la resistencia flexural de cuatro resinas acrílicas termopolimerizables utilizadas en la fabricación deprótesis totales.METODOLOGÍA: Se elaboraron 42 láminas de 3mm de espesor, 60mm de largo y 10mm de ancho, fueron todas procesadasde acuerdo a las indicaciones del fabricante, así como estandarizadas con un calibrador pie de rey electrónico; pulidas yabrillantadas de una sola cara y luego almacenadas en agua destilada a temperatura ambiente por dos semanas. Finalmentefueron sometidas a pruebas de flexión sobre el émbolo de carga de 500 Kg a una velocidad de 5mm ± 1 mm/min. Los resultadosse evaluaron con las pruebas de ANOVA y Tukey (p<0.001).RESULTADOS: La que alcanzó mayor resistencia flexural fue la resina acrílica EZ CRIL con un promedio de 94.36 ± 5.53MPa, VIPICril PLUS (VIPI) y Triplex Hot (Ivoclar) alcanzaron valores de 89.17 ±7.06 MPa y 87.85 ± 8.67 Mpa respectivamente,la que obtuvo menores resultados fue la resina acrílica IVOCAP con un promedio de 81.34 ± 5.72 MPa. Se encontródiferencia estadísticamente significativa, evaluada mediante la prueba de ANOVA (p<0.001). Mediante la prueba de comparacionesMúltiples de Tukey se encontró que los únicos dos grupos que muestran diferencias significativas son el grupo deIVOCAP y EZ CRIL con un valor de p < 0.001,CONCLUSIÓN: La resina acrílica Ez Cril (New Stetic) presentó mayor resistencia Flexural en comparación con las otrasresinas acrílicas; sin embargo todas las resinas acrílicas evaluadas alcanzaron valores superiores a los que la norma ISO 1567recomienda.
Evaluación de la resistencia a la erosión ácida de dos ionómeros de vidrio utilizados en la técnica restaurativa atraumática (TRA), modificados con un antibiótico
Authors: Torres M. G. , Mendoza T. R. , Guerrero I. J. , Yamamoto N. J.
Published: December 2019

RESUMENEn el presente estudio se evaluó la resistencia a la erosión ácida de dos ionómeros de vidrio de restauración, adicionados conciprofloxacino al 2%, ya que la sinergia que tiene este con otras sustancias lo hace una sal adecuada para el estudio y puedeser utilizado en la técnica restaurativa atraumática.OBJETIVO: Evaluar la resistencia a la erosión ácida del ionómero de vidrio adicionado con ciprofloxacino al 2%, según loslineamientos de la norma 96 de la ADA.MATERIALES Y MÉTODOS: Se utilizaron dos marcas comerciales de ionómero de vidrio GC Gold Label 2® y KetacTMMolar Easymix®, conformando cuatro grupos: El grupo control que fueron los ionómeros de restauración convencionales, yel grupo de estudio al que se le adicionó ciprofloxacino al 2%.RESULTADOS: Fueron evaluados mediante el análisis de varianza ANOVA de una vía y se observó que en la comparaciónentre los dos grupos, no hubo diferencia estadísticamente significativa (p>0.005).CONCLUSIÓN: La adición del ciprofloxacino al 2% no altera la resistencia a la erosión ácida de los ionómeros de vidriopara restauración, y puede considerarse un material para ser utilizado en la técnica TRA en estudios posteriores.
Espacio biológico: invasión, preservación y protocolos de acción en periodoncia y odontología restauradora
Authors: Zurita-Santisteban E. , Matta-Valdivieso E. , Salinas-Pietro E.
Published: December 2019

El concepto de “espacio biológico” ha sido ampliamente descrito por periodoncistas y odontólogos generales. Se denomina “espacio biológico” a la unión dentogingival que está constituida por el epitelio de unión y el tejido conectivo de inserción de la encía. Cuando se habla de “espacio biológico” no sólo se debe pensar en la longitud de la inserción gingival, sino que se debe relacionar con el grosor de la encía, el biotipo periodontal y la profundidad del surco gingival, puesto que todos estos parámetros se integran, y deben ser tomados en cuenta para comprender de manera exacta la morfología del tejido gingival supracrestal. La variabilidad de dimensiones de los componentes epitelial y conectivo que existe entre individuos, e incluso dentro del mismo individuo, es otro factor que debe ser considerado. El mantenimiento de una relación correcta de los tejidos periodontales con los márgenes de las restauraciones depende, además de la óptima adaptación de la restauración, también de la ausencia de invasión del espacio biológico, que es ocupado por los tejidos blandos presentes en la unión dentogingival. Estas invasiones llevan a complicaciones como la inflamación gingival, pérdida de hueso alveolar y recesiones gingivales. Esta revisión discute el concepto de “espacio biológico”, su relación con la salud periodontal, la odontología restauradora y su importancia en el mantenimiento de una restauración a largo plazo
Hallazgo radiológico incidental: cóndilo bífido, calcificación de ligamento estilohioideo y torus mandibular. Reporte de caso
Authors: Laquihuanaco-Coarita G. M. , Rodríguez-Cárdenas Y. A. , Ruíz-Mora G. A.
Published: December 2019

El presente reporte de caso describe un hallazgo radiológico incidental simultáneo de cóndilo bífido, calcificación de ligamentoestilohioideo y torus mandibular. Un estudio radiológico de rutina para fijación de implantes óseointegrados en unamujer de 56 años en el Centro de Diagnóstico por Imágenes de Lima–Perú, con imágenes panorámica y tomografía computarizadade haz cónico (TCHC), permitió encontrar incidentalmente alteraciones morfológicas unilaterales del cóndilomandibular y apófisis estiloides derechos, además de un torus mandibular lingual bilateral.
Hemorragia masiva con riesgo mortal por activación de inhibidores de la coagulacion posterior a cirugía ortognática. Un reporte de caso
Authors: Barona-Terán J.
Published: December 2019

La corrección de las desarmonías dentofaciales mediante osteotomías de los huesos maxilares se denomina cirugía ortognática,y es una práctica muy común dentro de la cirugía máxilofacial. Son técnicas que se encuentran perfectamenteprotocolizadas y a las que se llega después de una preparación ortodóncica previa, en la gran mayoría de los casos. Lascomplicaciones transoperatorias o postoperatorias son un riesgo inherente en cualquier cirugía, y entre las más problemáticasse encuentras las hemorragias postoperatorias, que pueden originarse por hipertensión, ligaduras de vasos noadecuadas, fístulas arteriovenosas, entre otras.Se reporta el caso de un paciente de 18 años de edad, que fue sometido a cirugía ortognática bimaxilar, él cuál una semanadespués presentó sangrado masivo a través de la boca, y epistaxis de aproximadamente 3.5 litros. Se describe elmanejo de la emergencia y el diagnóstico establecido por hematología de anticuerpos contra los factores de coagulación.
Traumatismo Dental con Complicación Radicular: Reporte de caso
Authors: Moreno-Medina M. , Rodríguez-Hidalgo A.
Published: December 2019

Las fracturas de la raíz también llamadas intra alveolares radiculares, son aquellas que afectan a la dentina, al cemento y lapulpa, se caracterizan por presentar patrones complejos de curación, debido al deterioro de la pulpa, el ligamento periodontal,la dentina y el cemento. La mayoría de estas fracturas se producen por un golpe directo contra el suelo, un cuerpo extrañoque incida sobre el diente o accidentes automovilísticos y deportivos. En el presente artículo se describe el tratamiento yseguimiento a 2 años 4 meses del caso de una niña de 10 años de edad que después de un traumatismo fue sometida a untratamiento no adecuado, que le causaba mucho dolor, radiográficamente se observó la ausencia del tercio apical en el diente21 y una movilidad grado III del mismo. Se modificó el tratamiento prolongando la vida del diente en boca.
Comités
Authors: Científica del Sur Estomatología
Published: December 2019

Comités
Digitized Uncertainty Handling of Pore Pressure and Mud-Weight Window Ahead of Bit: North Sea Example
Authors: Lothe Ane E. , Cerasi Pierre , Aghito Manuel
Published: December 2019

A digitized workflow from predrill pore-pressure modeling with a Monte Carlo approach until update of the pressure prognosis while drilling from (for example) sonic or resistivity data is described. The approach has the potential to reduce the uncertainty in the predicted mud-weight window ahead of the bit.

For the 3D pressure modeling, a basin modeling software is used, where the pressure compartments in the study area are defined by faults interpreted from seismic. Pressure generation and dissipation are calculated for the study area over millions of years, as the basin was subsiding and compaction was taking place. Key input parameters such as minimum horizontal stress, vertical stress, and frictional coefficients for failure criteria are varied. The output is pore-pressure profiles along the planned well path, with uncertainties.

The work presented in this paper was carried out on a North Sea data set. The results show that the uncertainty in the pore pressures will highly influence the uncertainty span in both the fracture gradient and the collapse gradient. Representing the mud-weight window in terms of the most likely collapse and fracturing curve, with corresponding minimum and maximum pore-pressure-derived limits on each side, makes for a more realistic prediction. It presents the uncertainty in the result in a simple visual form, using a “traffic light” approach.

While drilling, log data will automatically be used to update the pressure and mud-weight prognosis ahead of bit. The digital updated prognosis can help the drilling crew in decision making during drilling campaigns.
Evaluating the Performance of Surfactants in Enhancing Flowback and Permeability after Hydraulic Fracturing through a Microfluidic Model
Authors: Liang Tianbo , Xu Ke , Lu Jun , Nguyen Quoc , DiCarlo David
Published: December 2019

Hydraulic fracturing can create a large fracture network that makes hydrocarbon production from low-permeability reservoirs economical. However, water can invade the rock matrix adjacent to the created fractures and generate water blockage that impairs production. Using surfactants as fracturing-fluid additives is a promising method to enhance the fluid flowback, and thus mitigate the water blockage caused by invasion. It is imperative to understand how surfactants work during the fracturing and production stages, so as to maximize their effectiveness in production enhancement. In this study, an experimental investigation is conducted using a “chipflood” sequence that simulates fluid invasion, flowback, and hydrocarbon production from hydraulically fractured reservoirs. All experiments are conducted in a 2.5D glass micromodel that provides direct observation of in-situ phase changes when different Winsor types of microemulsions formed in the porous medium. The results provide direct evidence of the impact of the matrix–fracture interaction as well as water removal when surfactants are used. They further elucidate why surfactants under different Winsor-type conditions perform differently in mitigating the water blockage. This helps to clarify the screening criteria for optimizing flowback surfactant in hydraulic fracturing.
Emergence delirium and intranasal dexmedetomidine premedication in pediatric anesthesia: a retrospective study in plastic surgery
Authors: Palma Alessandra Di , Maldarelli Federica , Cimino Antonietta , Zama Mario , Picardo Sergio Giuseppe
Published: December 2019

Background Dexmedetomidine is increasingly used in the treatment of emergency delirium (ED) in pediatric patients. However, further evidence on its use in pediatric anesthesia and on potential differences in the reduction of ED according to patient’s age and type of anesthesia is required. Moreover, whether dexmedetomidine influences time of discharge from the surgical area remains unclear. We evaluated whether intranasal dexmedetomidine is effective in decreasing the incidence of ED in 106 children who had anesthesia for plastic surgery undergoing general or combined anesthesia at different ages. We also assessed if this drug has an impact on time to discharge from the surgical area. Methods In total, 106 children, aged 2–10 years, were enrolled in this retrospective study. Among them, 50 have been premedicated with dexmedetomidine (dexmedetomidine group); the remaining 56 patients served as controls (control group). The incidence of ED was evaluated according to the use of dexmedetomidine premedication, age and type of anesthesia (general vs combined). The length of anesthesia and duration of staying in the surgical area were also analyzed. Results Three patients who received dexmedetomidine premedication showed ED (6%), compared with 43 patients in the control group (77%; p<0.05). This lower incidence of ED was also present when stratifying patients according to the type of anesthesia or age. We observed no significant difference between the dexmedetomidine group and control group in terms of discharge from surgical area. Conclusions Premedication with dexmedetomidine is associated with decreased incidence of ED, regardless of patients’ age or type of anesthesia and without seemingly increasing the timing of discharge after surgery.
Development and validation of a predictive model for composite adverse outcomes in primary postpartum haemorrhage in a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe.
Authors: Ngwenya Solwayo
Published: December 2019

BackgroundPrimary postpartum haemorrhage remains an important cause of maternal mortality and morbidity globally. It is difficult to predict. There are very few predictive models on composite adverse outcomes on postpartum haemorrhage that are available in the literature. The aim of this study was to develop and validate multivariable predictive model to assist clinicians in decision-making after a diagnosis of postpartum haemorrhage is made, and to prevent the development of composite adverse outcomes.MethodsThis was a retrospective cross-sectional study that covered the period from 1 July 2016 to 30 November 2019, at Mpilo Central Hospital. The study included participants that had a diagnosis of postpartum haemorrhage within 24 hours of delivery at Mpilo Central Hospital. The independent variables included socio-demographic factors, laboratory tests, clinical outcomes, causes and the management of PPH. The outcome of interest for this research was composite adverse outcome in PPH. Predictor variables that had a p<0.2 from the bivariate correlations analyses were considered for the multivariable stepwise backward logistic regression. Performance of the model was assessed with a calibration slope. Discrimination ability was evaluated using the area under curve of the receiver operating characteristic (AU ROC). Internal validation of the model was assessed using bootstrap method. ResultsThe final predicted probability model for composite adverse maternal outcomes was; logit (logarithm of the odds) (pi) = 0.141 + (2.35 x 10-1 x blood loss) + (-1.18 x 10-1 x platelets) + (0.57 x 10-1 x parity) + (2.27 x 10-1 x ruptured uterus).The model was well calibrated. The discrimination ability of the model was excellent. The AU ROC curve was 0.890 (95% CI 0.830-0.949, p<0.0001). Internal validation was by bootstrapping, and the model was still a good fit for the data with a p<0.0001.ConclusionsA predictive model for composite adverse outcomes in PPH was developed. It had a good discriminatory ability, with an AU ROC of 0.890 (95% CI 0.830-0.949). This predictive model for composite adverse outcomes could help clinicians to be alerted to which women with PPH are most likely to develop composite adverse outcomes thereby preventing maternal deaths.
Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review
Authors: Sutiman Natalia , Koh Janine Cynthia , Watt Kevin , Hornik Christoph , Murphy Beverly , Chan Yoke Hwee , Lee Jan Hau
Published: December 2019

BACKGROUNDTo identify alterations in pharmacokinetics in children on extracorporeal membrane oxygenation (ECMO), identify knowledge gaps and inform future clinical pharmacology studies.METHODSWe systematically searched the following databases from earliest publication until November 2018: MEDLINE, CINAHL and EMBASE, using a controlled vocabulary and keywords related to: “ECMO”, and “pharmacokinetics”, “pharmacology”, “drug disposition”, “dosing” and “pediatrics”. Inclusion criteria were: study population aged <18 years, supported on ECMO for any indications, receiving any medications while on ECMO and reported pharmacokinetics data. Clearance and/or volume of distribution (Vd) values were extracted from the included studies.RESULTS41 studies (total patients=574) evaluating 23 drugs met the inclusion criteria. The most common drugs studied were anti-microbials (n=13), and anticonvulsants (n=3). 28 studies (68%) were conducted in children < 1 year of age. 33 studies (80%) were conducted without intra-study comparisons to non-ECMO controls. Increase in Vd attributable to ECMO was demonstrated for 9 (56%) drugs: cefotaxime, gentamicin, piperacillin/tazobactam, fluconazole, micafungin, levetiracetam, clonidine, midazolam and sildenafil (range: 23-345% increase relative to non-ECMO controls), which may suggest the need for higher initial dosing. Decreased Vd was reported for 2 drugs: acyclovir and ribavirin (50 and 69%, respectively). Decreased clearance was reported for gentamicin, ticarcillin/clavulanate, bumetanide and ranitidine (range: 26-95% decrease relative to non-ECMO controls). Increased clearance was reported for caspofungin, micafungin, clonidine, midazolam, morphine and sildenafil (range: 25-455% increase relative to non-ECMO controls).CONCLUSIONSThere were substantial pharmacokinetic alterations in 70% of drugs studied in children on ECMO. However, studies evaluating pharmacokinetic changes of many drug classes, and those that allow direct comparisons between ECMO and non-ECMO patients, are still lacking. Systematic evaluation of pharmacokinetic alterations of drugs on ECMO that incorporate multi-drug opportunistic trials, physiologically based pharmacokinetic modeling, ex-vivo studies and other methods are necessary for definitive dose recommendations.
Lung-heart pressure index is a risk factor for acute respiratory distress syndrome (ARDS): A machine learning and propensity score-matching study.
Authors: Yu Xue-Shu , Pan Xiao-Jun , Chen Zhi-Qiang , Hu Yu-Feng , Shu Jie , Xu Shun-Yao , Zhang Xian-Wei , Jiang Hao , Chen Wen-Jing , Ye Yin-Cai , Pan Jingye
Published: December 2019

Background Ventilator-induced lung injury (VILI) and haemodynamic instability play vital roles in acute respiratory distress syndrome (ARDS). The principle of driving pressure (DP) is the response to “volutrauma”, and the mean arterial pressure (MAP) is a haemodynamic systemic manifestation. In this study, we explored a novel lung-heart pressure index (LHPI) based on DP and MAP and explored its prognostic value in patients with ARDS.Methods This is a retrospective study based on the MIMIC-III database. ARDS patients who had undergone mechanical ventilation for more than 48 hours were selected through structured query language. The focus of the study was whether a high LHPI was associated with 30-day mortality and whether its predictive power was better than that of DP and mechanical power (MP). We used random forest, propensity-score matching, and logistic regression to test our hypothesis.Results A total of 448 ICU ARDS patients were enrolled. The mortality rate of ARDS patients was 29.02%. The LHPI was more important than DP and MP in the random forest. A significant adverse effect of high LHPI on 30-day mortality was observed in the high-LHPI group compared to the effect observed in the low-LHPI group (OR=1.86, 95% CI 1.08–3.26, p =0.027). More importantly, LHPI was significantly better than DP (NRI=0.054, 95% CI (0.014-0.094), P=0.008; IDI=0.011, 95% CI (0.002-0.019), P=0.014) and MP (NRI=0.061, 95% CI (0.001-0.122), P=0.049; IDI=0.047, 95% CI (0.022-0.071), P<0.001) in predicting mortality.Conclusions The study showed that the LHPI was a powerful prognostic indicator of 30-day mortality in ARDS patients, and its predictive discrimination was better than that of DP and MP. Further experimental trials are needed to investigate whether adjusting treatment decisions according to the LHPI will significantly improve clinical outcomes.
Image quality in telehealth: challenges in developing countries
Authors: Chowdhury Avijit , Hafeez-Baig Abdul , Gururajan Raj , McCubbin Amanda , Sharif Mirza Akmal
Published: December 2019

The purpose of this paper is to explore the underlying challenges in the telehealth environment in India and Pakistan that impede the delivery of high-quality images between a patient and health care professional. An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding image quality, which is used for the diagnosis and treatment. This cross-sectional qualitative study used semi-structured interviews with healthcare professionals in both India and Pakistan. The interviews were analyzed using a thematic analysis, which revealed three major themes. These themes being: ICT infrastructure and connectivity, high-quality images were produced by trained technicians in an organized telemedicine set-up; and image quality can be degraded by multiple transmissions. Findings indicate that in both countries the main underlying challenge is the lack of consistency in the network infrastructure between urban, rural and remote areas. Additionally, training patients to use hand-held devices to take high-quality images future could hold the key to improving the reliability and consequently the quality of images transmitted between patients and health care professionals.
ToxoGRA15II promote macrophages polarization against Hepatic carcinoma by targeting TRAF6
Authors: Cai Yihong , Yu Yanxia , Wang Yanling , Zhang Yuan , Yu Li , Sheng Jilong
Published: December 2019

Background: There is increasing evidence that tumor-associated macrophages play an important role in the development of tumors. The more macrophages, the faster the tumors develop. On the one hand, studies have shown that the dense granule protein molecule of Toxoplasma gondii (ToxoGRA15II) tends to induce the differentiation of classically activated macrophages (M1). GRA15II can also induce M2 reversal polarized to M1. Promote the occurrence of Th1 immune response.Methods: Here, we constructed LV-gra15Ⅱ, which was transferred to M1-like and/or M2-like macrophages. Furthermore, we injected LV-gra15Ⅱ by vein into tumor bearing C57BL/6 mice.Results: We found that M2-like macrophages could be polarized to M1-like macrophages, inducing NO, IL12, TNF-αexpression. Mechanistically, ToxoGRA15Ⅱ activate NF-κB signaling pathway by binding to TRAF6. Additionally, LV-gra15Ⅱ promoted p65 nuclear translocation to polarize TAM to M1-like macrophages and induce IFN-γ,TNF-α,IL12, NO expression, inhibiting tumor growth. Subsequently, ToxoGRA15Ⅱ has a role in cancer pathway and metabolism.Conclusions: Taken together, these findings could lead to the development of immunotherapy strategies to tumor, due to ToxoGRA15Ⅱ as polypeptide effector molecule of T.gondii and non-toxicity to mammalians.
Identifying Potential Markers for Monitoring Progression to Ovarian Cancer Using Plasma Label-free Proteomics
Authors: Wang Wenjie , Xie Hongyu , Xia Bairong , Zhang LiuChao , Wang Ce , li kang , Hou Yan
Published: December 2019

PurposeCancer antigen 125 (CA125) is considered to have high sensitivity but poor specificity for ovarian cancer. New biomarkers utilized to early detect and monitor the progression of ovarian cancer patients are critically needed. Methods A total of 80 patients including 16 early stage, and matched with 17 late stage, 23 benign ovarian tumor (BOT) and 24 uterine fibroid (UF) patients were utilized to perform plasma proteomics analysis using isobaric tag for relative and absolute quantitation (iTRAQ) method to identify differential diagnostic proteins of ovarian cancer patients. A validation set of 9 early stage, 11 late stage, 17 BOT and 16 UF collected by an independent cohort of samples with the same matching principles was examined to confirm the expressed levels of differential expression proteins by ELISA analysis. Results CRP and ARHGEF 11 were identified as potential diagnostic biomarkers of ovarian cancer. Results of area under the curve (AUC) analysis suggested that combination of diagnostic proteins and CA125 achieved a much higher diagnostic accuracy compared with CA125 alone (AUC values: 0.98 versus 0.80), especially improved the specificity (0.97 versus 0.77). In addition, elevated plasma CRP levels were associated with increased risk of ovarian cancer. Conclusions Current study found that plasma protein CRP was an indicator for monitoring the progression of ovarian cancer. Combination of plasma protein biomarkers with CA125 could be utilized to early diagnose of ovarian cancer patients. Keywords ovarian cancer, proteomics, diagnosis, progression, CRP
LncRNA NCRNA00173 is down-regulated in pediatric osteosarcoma and suppresses cell metastasis of osteosarcoma cells through regulating PI3k/Akt pathway
Authors: Zhao Zhongquan , Chen Jiechao , Xia Dezhi
Published: December 2019

Background: Osteosarcoma (OS) is a primary malignant tumor with high mortality and disability rate in childhood and adolescent, whereas the influence of LncRNA00173 (NCRNA00173) on pediatric OS progression is not obvious yet. Therefore, this study aimed to investigate the expression of NCRNA00173 in pediatric OS and its effect on OS progression. Methods: In our study, qRT-PCR was adopted to test the NCRNA00173 expression in 40 pairs of pediatric OS tissues and OS cell lines. Kaplan-Meier method and Cox proportional hazard model were performed to analyze the prognosis of pediatric OS patients. The cell proliferation, apoptosis, migration and invasion of U2OS and HOS cells were test by MTT assay, flow cytometry, wound-healing, and transwell assay, respectively. The protein expression levels of PI3K/Akt pathway were measured by western blot. In addition, tumor growth in nude mice was also detected. Results: The expression of NCRNA00173 was down-regulated and relevant with poor prognosis in pediatric OS. Overexpression of NCRNA00713 inhibited cell proliferation, migration and invasion, as well as accelerated cell apoptosis in U2OS and HOS cells. Overexpression of NCRNA00713 suppressed tumor growth in nude mice. The protein expression of p-PI3K and p-Akt were remarkedly decreased in U2OS and HOS cells after transfection with NCRNA00173. In addition, 740 Y-P (PI3K/Akt pathway activator) eliminated the impact of NCRNA00173 in HOS. Conclusions: NCRNA00173 was down-regulated in pediatric OS and suppressed metastasis of OS cells by regulating PI3k/Akt pathway.