bluuebunny/crossref_metadata_2025 huggingface dataset:
Temsil Maliyetleri ve Finansal Kısıtlar: Borsa İstanbul Metal Ana Endeksi Firmaları Üzerine Bir Uygulama
Authors: TOPALOĞLU Emre Esat
Published: October 2019

Çalışmada, temsil
maliyetlerinin finansal kısıtlara olan etkisini ortaya çıkarmak amaçlanmıştır.
Bu doğrultuda Borsa İstanbul Metal Ana Endeksi’nde devamlı olarak faaliyet
gösteren 12 firmanın 2008-2017 dönemindeki verileri, statik ve dinamik panel
veri analizleri ile incelenmiştir. Çalışmada, firma
yöneticileri ile firmaya borç verenler arasında ortaya çıkan temsil maliyetleri
ile finansal kısıt arasında istatistiksel olarak anlamlı ve negatif ilişki
tespit edilirken, yöneticiler - hissedarlar arasında ve hissedar - borç
verenler arasında ortaya çıkan temsil maliyetleri ile finansal kısıt arasında
ise istatistiksel olarak anlamlı bir ilişki tespit edilememiştir. Dolayısıyla,
BIST Ana Metal Endeksinde faaliyet gösteren firmaların finansal kısıtlar ile
karşı karşıya kalmamak ya da finansal kısıtları minimize edebilmek için
yönetici ile borç verenler arasında oluşabilecek temsil maliyetlerini dikkate
almaları gerekmektedir.
Tuhfe-i Hattâtîn’de Hat Sanatını Ele Alan Şiirler
Authors: GÜNEŞ Özlem
Published: October 2019

On sekizinci yüzyılda İstanbul’da yaşayan Müstakimzâde
Süleyman Sâdeddin Efendi ömrünü ilme tahsis etmiş önemli bir şahsiyettir. Eserlerinden
Tuhfe-i Hattâtîn, hattatları konu alan bir biyografi kitabıdır. Çalışmanın
amacı, Tuhfe-i Hattâtîn’de yer alan hattat şairlerin şiirlerini,
özellikle “hat”tı ele alan manzumelerini incelemektir. Böylelikle sanat,
edebiyat, mimari, iktisat, düşünce, teoloji ve ahlak gibi çeşitli alanlardaki
temsil edici eserlerin, İslam medeniyetinin kurucu kaynağı olan Kur’an
üzerinden nasıl sentezlendiğini, bu kaynağa yapılan atıfları, sanat dallarının
birbirleriyle kurdukları ilişkileri özellikle hat-şiir / hattat-şair bağlamında
ele almaktır.
Endüstri 4.0 ve Eğitim: Bir Türkiye Perspektifi
Authors: ÖZEN Hamit
Published: October 2019

İnsanlık
sanayi devrimin dördüncüsüne bilişim teknolojileri ve endüstri faaliyetlerinin
bir araya getirilmesiyle girmektedir. Bu yeni çağın adı Endüstri 4.0 çağıdır. Bu
çağın çıkışına neden olan faktör eğitimin entelektüel kapasitesi yüksek, bütün
ve parçalar arasındaki ilişkileri ifade edebilen bireyler yetiştirmesidir. Bu
çalışmanın amacı Türkiye’nin Endüstri 4.0 kapasitesine yönelik bir analiz yapmak
ve bazı sosyal ve ekonomik dinamiklere yönelik önerilerde bulunmaktır. Bunun
için Türkiye ile bazı Ekonomik İşbirliği ve Kalkınma Örgütü (OECD) ülkelerinin
ve bazı gelişmekte olan ülkelerin demografik ve ekonomik, insan sermayesi,
eğitim, politik ve rekabet edebilirlik göstergeleri tartışılmıştır. Sonuç
olarak Türkiye’de Endüstri 4.0 çağını karşılayabilecek temel göstergelerin OECD
ülkelerinden daha düşük düzeyde olduğu, eğitimin de çağın ihtiyaçlarını
karşılamaktan uzak olduğu sonucuna ulaşılabilir.
Turist Güvenliğinin Risk Azaltma Davranışı, Tavsiye Ve Tekrar Ziyaret Etme Niyeti Üzerindeki Etkisi: İstanbul’u Ziyaret Eden İranlı Turistler Üzerine Bir Araştırma
Authors: SERT Ayşe Nevin
Published: October 2019

Turist
güvenliği turizmin gelişimi açısından önemli bir kavramdır. Turistlerin
güvenlik algıları ve bu algılardan kaynaklı davranışlarının anlaşılması
gerekmektedir. Çalışmada İstanbul’a gelen İranlı turistlerin İstanbul ile
ilgili güvenlik algıları ve bu algılara bağlı olarak oluşan risk azaltma
davranışları incelenmiştir. Ekim-Kasım, 2018 tarihlerinde İstanbul’u ziyaret
eden 389 İranlı turiste yüz yüze anket uygulanmıştır. Yapılan çalışmada
algılanan güvenliğin risk azaltma davranışı, tavsiye etme ve tekrar ziyaret
etme niyeti üzerinde etkili olduğu bulgulanmıştır. Risk azaltma davranışlarıyla
ilgili olarak İranlı turistlerin özellikle potansiyel bir kurban durumuna
düşebilecekleri durumlardan kaçındıkları ve çevrelerinde olup bitenlere karşı
uyanık oldukları görülmüştür. Bekar, tatile yalnız çıkanlar, gelir seviyesi yüksek,
45-49 yaş aralığındaki kişilerin güvenlik algılarının yüksek olduğu tespit
edilmiştir
Rehberlik Öğretmenlerinin Bireyselleştirilmiş Eğitim Programı (BEP) Biriminin İşleyişine İlişkin Görüşleri
Authors: YAZICIOĞLU Tansel
Published: October 2019

Bu
araştırma, okullarda oluşturulan Bireyselleştirilmiş Eğitim Programı (BEP)
Geliştirme Birimlerinin işleyişine yönelikrehberlik öğretmenlerinin görüşlerinin
belirlenmesi amacıyla yapılmıştır. Araştırmada nitel araştırma yöntemlerindengörüşmeye
dayalı tümevarım analiz modeli kullanılmıştır. Araştırmanın çalışma grubunu 2018-2019
eğitim-öğretim yılında çalışmaya katılmayı gönüllü olarak katılmayı kabul eden
14 rehberlik öğretmeni oluşturmuştur. Araştırma Ankara İli Çankaya İlçesi’nde
yürütülmüştür. Araştırmanın verileri yarı-yapılandırılmış görüşmeler yoluyla
toplanmıştır. Ayrıca öğretmenlerin genel bilgilerini elde etmek amacıyla
demografik bilgi formu hazırlanmıştır. Araştırmanın sonuçları okullarda BEP
birimlerinin oluşturulduğunu ancak amacına yönelik işlemediğini ortaya
koymuştur. Araştırma sonuçları ayrıca BEP geliştirme birimlerinin daha çok
rehberlik öğretmenlerin sorumluluğunda yürütüldüğünü, ekip üyelerinin işbirliği
içinde hareket etmediklerini göstermiştir.
Üniversite Gençliğinin Değerlerinin Farklılaşan Yönleri: Değerler ve Dindarlık İlişkisi Bugün Bizlere Ne Anlatıyor?
Authors: AKSAN Gamze , ALTUNSU SÖNMEZ Özlem
Published: October 2019

Üniversite gençliğinin değerleri
üzerine ülkemizde 1980’li yıllardan itibaren yapılan çalışmalar; dindarlığa ve
manevi yaşama ilişkin ifadeler ile bireyci, hazcı ve maddi değerlere yönelik
ifadelerin gruplandığı faktörler arasında negatif yönlü bir ilişkinin
varlığından bahsetmektedir. Güncel çalışmalardan biri, üniversite gençliğinde maddi
ve manevi değerler arasında daha öncekilerin aksine pozitif yönlü bir ilişki bulgulamıştır.
Bu durum günümüzde gençliğin haz, hırs, imaj gibi uyarıcı değerlerle dindarlığı
da içeren geleneksel değerleri benzer biçimde algıladığını işaret etmektedir.Bu
farklı anlamak amacıyla bu çalışmada, gençliğin içsel ve dışsal dini yönelim
düzeyleri ölçülerek değerler ve dindarlık arasındaki ilişki daha derinlemesine
ele alınmıştır. Araştırma Selçuk Üniversitesinde 2019 yılında öğrenim gören 1194
kişi ile gerçekleştirilmiş ve değer alt boyutları ile dindarlık arasında
yönelim farkı olmaksızın pozitif yönlü bir ilişikli tespit edilmiştir. Bu durum
bize üniversite gençliğinin değerlerinde ciddi bir değişim olduğunu göstermektedir.
Evaluation of positive serological screening test rates in blood donors with ABO and Rh type blood groups
Authors: Eren Canan
Published: October 2019

Background: Blood transfusion is a life-saving method in emergencies. However, it also carries the risk of pathogen transmission, which is called transfusion transmitted infections (TTIs). All donated blood samples were screened for hepatitis B surface antigen (HBsAg), anti-hepatitis C virus antibody (anti-HCV), anti-human immunodeficiency virus antigens (anti-HIV½) and syphilis using Venereal Disease Research Laboratory (VDRL) test.

This study was designed and carried out to determine the seroprevalences of TTIs among blood donors with different ABO and Rh blood groups. Identification of a relation between different blood groups and TTIs was anticipated.

Methods: All blood donors data obtained from the Blood Center of Marmara University Pendik Training and Research Hospital between January 2013 and October 2018 are analyzed retrospectively. Serum samples were examined for HBsAg, anti-HCV, anti-HIV½, and VDRL.

Results: HBsAg and anti-HIV½ positivity positivity rates were not statistically different according to ABO blood groups (p>0.05). Anti-HCV positivity rates are partially statistically significant (p<0.05). While the incidence of anti-HCV in patients with AB Rh (+) cases was significantly higher than that of 0 Rh (+), A Rh (+) and AB Rh (+) groups, no significant difference was found for the other analyzed blood groups (p>0.05). VDRL positivity rates did not differ significantly (p>0.05). Seropositive cases, as reported by Rh type blood group; HBsAg, anti-HCV, anti-HIV½, and VDRL positivity rates were not statistically significant (p>0.05).

Conclusions: No significant relationship was found among TTIs and ABO and Rh type blood groups. For blood transfusion safety, screening tests should always and carefully be performed.
Adherencia a la estrategia minuto de oro en sala de partos de una institución de segundo nivel, de Cali (Colombia), junio-agosto de 2017: estudio de corte transversal
Authors: Moreno-Reyes Sandra Patricia , Calvo-Bolaños Paola Andrea , Cruz-Mosquera Freiser Eceomo , Cubides-Munévar Ángela Mayerly , Estupiñán-Pérez Víctor Hugo
Published: October 2019

Objetivo: determinar la adherencia global y por componentes a la estrategia minuto de oro en médicos que atienden recién nacidos en una entidad de mediano nivel de complejidad. Materiales y métodos: estudio de corte transversal; se incluyeron recién nacidos vivos de partos vaginales espontáneos atendidos por médicos pediatras, ginecólogos o internos en sala de partos de un hospital universitario de la ciudad de Cali, Colombia, en el 2017. Se excluyeron fetos con malformaciones congénitas mayores, gemelares y con menos de 34 semanas de edad gestacional. Muestreo sistemático. Tamaño muestral: 150 recién nacidos. Se evaluaron las características basales de los recién nacidos y sus madres, y la adherencia a la estrategia minuto de oro y sus componentes. Se hizo análisis descriptivo. Resultados: la adherencia al minuto de oro en médicos pediatras fue del 65,6 % (IC 95 %: 53,8-78,4), en ginecobstetras, de 33,33 % (IC 95 %: 4,3-77,7), y en médicos internos, de 75,3 % (IC 95 %: 64,8-85,1). La menor frecuencia se dio en la colocación del gorro al recién nacido, 64,90 % (IC 95 %: 56,7-72,4), y poner al bebé piel a piel sobre la madre, 65 % (IC 95 %: 55,9-74,4); la mayor frecuencia se presentó en cubrir al recién nacido con paños calientes, 98,6 % (IC 95 %: 95,3-99,8), y la ventilación con presión positiva en los casos en los que no había respuesta a la estimulación inicial, 100 % (IC 95 %: 30-100). Conclusiones: los resultados obtenidos sobre el grado de adherencia de los profesionales sugieren la necesidad de realizar procesos continuos de educación y evaluación sobre la aplicación de esta estrategia de reconocida efectividad en las instituciones que ofrecen el servicio de atención de partos.
Coking coals of the Arctic zone of Russia
Authors: Vyalov Vladimir I. , Gurevich Alexandr B. , Volkova Galina M. , Skiba Darya A. , Shishov Evgeny P. , Chernyshev Artem A.
Published: October 2019

Rational and cost-effective development of the richest hydrocarbon resources of the Arctic region of Russia is impossible without the resumption of solid fuel production. On the Arctic coast of Russia there is the largest base of coking coals of valuable ranks, which requires the study and active development in the framework of the overall strategy of development of fuel and energy resources of the Russian North and, in general, the fuel and energy complex of the country. The most valuable in quality and properties deposits and basins of coking coals of the Arctic zone of Russia are considered. Among them are the Taimyr, Tunguska, Zyryanka and Bering basins. The features of coal-bearing, matter-petrographic composition and quality, the basic properties of coal of basins and promising fields, their resource and geological characteristics are given. Recommendations for their further study are given, the prospects of their development and transportation of coal along the Northern Passage are discussed.
Impact of Reduced Fluoroquinolone Use on Clostridioides difficile Infections Resulting From the Fluoroquinolone-Resistant Ribotype 027 Strain in a Veterans Affairs Medical Center
Authors: Redmond Sarah N. , Silva Sandra Y. , Wilson Brigid M. , Cadnum Jennifer L. , Donskey Curtis J.
Published: October 2019

Background: Fluoroquinolone restriction has been proposed as a control measure for Clostridioides difficile infection (CDI) outbreaks associated with fluoroquinolone-resistant ribotype 027 strains. However, relatively few reports of fluoroquinolone restriction interventions have evaluated the impact on C. difficile strain types and fluoroquinolone resistance.Methods: In a hospital and affiliated long-term care facility (LTCF), antimicrobial stewardship and environmental cleaning interventions were implemented between 2009 and 2018, and C. difficile isolates during this period (~20 per year) were ribotyped and tested for fluoroquinolone resistance by moxifloxacin minimum inhibitory concentrations (MICs). Pearson’s correlation coefficient was used to assess the association between use of fluoroquinolones and the percentage of CDI cases due to the 027 strain over time.Results: Between 2009 and 2018, prescribing of fluoroquinolones to inpatients decreased by 43%, coinciding with significant reductions in the healthcare-associated CDI rates in the hospital and LTCF and a decline in the percentage of C. difficile isolates that were ribotype 027 from 70% to 10%. Ninety-five percent of ribotype 027 and 6% of non-027 isolates were moxifloxacin resistant. Hospital fluoroquinolone use was strongly correlated with the incidence of hospital-associated CDI (r = 0.79, 95% confidence interval, 0.31-0.95), but LTCF fluoroquinolone use was not correlated with LTCF-associated CDI (r = 0.29, 95% confidence interval, -0.43-0.77). During the study period, there were statistically significant downward trends in the use of penicillins, intravenous vancomycin, carbapenems, and clindamycin.Conclusion: Our results provide support for fluoroquinolone restriction as a control measure for CDI outbreaks due to fluoroquinolone-resistant 027 strains, but also highlight the need for randomized trials as factors such as reduction in other antibiotic classes and improved cleaning may also impact CDI rates.
RNA Isolation of Dengue Virus Type 2 with Different Precipitation Solvents : Methanol, Chloroform, and 2-Isopropanol.
Authors: Untoro Yovilianda Maulitiva , Sucipto Teguh Hari , Setyawati Harsasi , Churrotin Siti , Amarullah Ilham Harlan , Wardhani Puspa , Aryati Aryati , Ueda Shuhai , Soegijanto Soegeng
Published: October 2019

Dengue virus distributed in tropical and subtropical regions in the world. DENV viruses are transmitted between humans primarily by Aedes aegypti and Aedes albopictus mosquitoes and are endemic in most areas in which the vectors occur. Four serotypes of dengue virus are DENV-1, DENV-2, DENV-3 and DENV-4. DENV-2 is comprised of six genotypes. Ethanol precipitation is a commonly used technique for concentrating and de-salting nucleic acids (DNA or RNA) preparations in aqueous solution. RNA isolation by combining Guanidinium thiocyanate and phenol reported has been reported. In this report, we investigated RNA isolation from DENV-2 using QIAamp Mini Kit with 2-Isopropanol, Methanol, Chloroform precipitation solvent. Electrophoregram showed DNA band as  the result of RNA isolation with methanol and 2-isopropanol are produced quite well. Dna band of the of RNA isolation with chloroform solvent has the lowest intensity than methanol and 2-isopropanol. This study showed that methanol and 2-isopropanol  can used as precipitation solvent for isolating RNA.
SYNTHESIS AND CHARACTERIZATION OF CASSAVA PEEL CARBON ACTIVATED USING ZnCl2¬
Authors: Setiyoningsih Luki Aprilliya
Published: October 2019

In this study, to determine the characteristics of charcoal from the manufacture using a modification tool, and to determine the effect of system density variation. Activated charcoal is made through several stages namely, dehydration, carbonization and activation. The use of the modifikation at the carbonization stage will result in different activated charcoal. The activation proses used in chemical activation by immersing the charcoal in a ZnCl2 activator solution. The charcoal massa period used is 1:1 with the charcoal massa : the activator period. Comparison of the massa used to produce increased system density of 2%, 4%. 6%, 8%, and 10%. The activation time used in accordance with the previous study was 8 hours. The active charcoal made using the modified means is obtained for the optimum 2% effect of system density at 8 hours of activation time. Characteristic values obtained at 2% system density were 3.67% moisture content, ash content 13.5%, iod absorption 277 mg / g, and density 0.31 g / mL.Keyword:activated charcoal, modifiers, chemical activation
DEKOLORISASI AIR LIMBAH PENGOLAHAN GURITA MENGGUNAKAN METODE AOT(ADVANCE OXIDATION TREATMENT) DENGAN REAGEN FENTON
Authors: Supriyanto Ganden , Nisak R Khoirun , Abdulloh Abdulloh
Published: October 2019

ABSTRACT This research aims to determine the effectiveness of Advance Oxidation Treatment (AOT) method with the use of Fenton reagent in decolorization of octopus canning wastewater’s red colour. The use of Fenton reagent (H2O2 and Fe2+) will produce hydroxyl radicals (∙OH) that will oxidize the red colour so the octopus canning wastewater to be colourless and safe to discharged into the environment. Determination of octopus canning wastewater's decolorization is done by determining the change of red color's intensity using Pt/Co scale. The main parameter in determining the decolorization of octopus canning wastewater using Advanced Oxidation Treatment (AOT) with Fenton reagent are time, concentration of Fe2+, concentration of H2O2, and pH. The maximum decolorization of octopus canning wastewater was reached at following condition rarely 55 minutes, with Fe2+ concentration of 42,86 ppm, H2O2 concentration of 85,71 ppm, and pH 4. With a capacity of red color’s decolorization is 49,08 %. Key words : Advance Oxidation Treatment (AOT), decolorization, Fenton reagent    ABSTRAK Penelitian ini bertujuan untuk mengetahui efektifitas metode Advance Oxidation Treatment  (AOT)  dengan menggunaan reagen Fenton dalam mendekolorisasi warna merah yang terdapat dalam air limbah pengolahan gurita. Penggunaan reagen Fenton (H2O2 dan Fe2+) akan menghasilkan radikal hidroksil (∙OH) yang bisa menghilangkan warna merah yang terdapat di dalam limbah sehingga limbah menjadi tidak berwarna dan aman untuk dibuang ke lingkungan. Penentuan dekolorisasi air limbah pengolahan gurita dilakukan dengan menentukan perubahan intensitas warna merah menggunakan skala Pt/Co. Parameter utama yang digunakan dalam metode Advance Oxidation Treatment  (AOT) adalah waktu, konsentrasi Fe2+, konsentrasi H2O2, dan pH. Hasil optimum dari dekolorisasi air limbah pengolahan gurita adalah pada waktu 55 menit, konsentrasi Fe2+ 42,86 ppm, konsentrasi H2O2 85,71 ppm, dan pH 4. Dengan kapasitas dekolorisasi warna merah sebesar 49,08 %. Kata kunci  : Advance Oxidation Treatment  (AOT), dekolorisasi, reagen Fenton
SUHU DAN WAKTU HIDROTERMAL DALAM SINTESIS ZSM-5 DARI METAKAOLIN
Authors: Hartati Hartati , Widati Alfa Akustia , Purwaningsih Aning , Kristanti Alfinda Novi , Rohmah Anik Fathur
Published: October 2019

AbstrakSintesis ZSM-5 dilakukan dari metakaolin terdealuminasi tanpa penambahan templat organik. Sintesis dilakukan melalui pengaturan suhu hidrotermal mulai suhu 120oC, 150o, dan 170oC. Hasil sintesis dikarakterisasi dengan difraktometer sinar-X , spektrometer FTIR, dan adsorpsi/desorpsi nitrogen. Pengaturan suhu hidrotermal pada 120oC selama 24 jam belum menghasilkan ZSM-5, sedangkan sintesis pada suhu 150oC selama 24 jam diperoleh hasil ZSM-5 dengan kristal yang cukup baik. Hidrotermal pada 170o tetap dapat membentuk ZSM-5 dengan pengotor mordenit dan kurang kristalin dibandingkan sintesis pada 150oC. Kata kunci: AbstrakSintesis ZSM-5 dilakukan dari metakaolin terdealuminasi tanpa penambahan templat organik. Sintesis dilakukan melalui pengaturan suhu hidrotermal mulai suhu 120oC, 150o, dan 170oC. Hasil sintesis dikarakterisasi dengan difraktometer sinar-X , spektrometer FTIR, dan adsorpsi/desorpsi nitrogen. Pengaturan suhu hidrotermal pada 120oC selama 24 jam belum menghasilkan ZSM-5, sedangkan sintesis pada suhu 150oC selama 24 jam diperoleh hasil ZSM-5 dengan kristal yang cukup baik. Hidrotermal pada 170o tetap dapat membentuk ZSM-5 dengan pengotor mordenit dan kurang kristalin dibandingkan sintesis pada 150oC. Kata kunci: ZSM-5, metakaolin, terdealuminasi, tanpa templat, pengaturan suhu dan waktu Abstract             Synthesis of ZSM-5 is carried out from dealuminated metakaolin without the addition of organic template. The synthesis is done by setting the hydrothermal temperature from 120oC, 150oC, and 170oC. The results were characterized by an X-ray diffractometer, FTIR spectrometer, and nitrogen adsorption / desorption. Hydrothermal temperature setting at 120oC for 24 hours has not produced ZSM-5, while the synthesis at 150oC for 24 hours was obtained ZSM-5 with good crystals. Hydrothermal at 170 °C can still form ZSM-5 with mordenite impurities and less crystalline than synthesis at 150 °C. Keywords: ZSM-5, dealuminated metakaolin, without organic  templates, temperature and time settings Abstract             Synthesis of ZSM-5 is carried out from dealuminated metakaolin without the addition of organic template. The synthesis is done by setting the hydrothermal temperature from 120oC, 150oC, and 170oC. The results were characterized by an X-ray diffractometer, FTIR spectrometer, and nitrogen adsorption / desorption. Hydrothermal temperature setting at 120oC for 24 hours has not produced ZSM-5, while the synthesis at 150oC for 24 hours was obtained ZSM-5 with good crystals. Hydrothermal at 170 °C can still form ZSM-5 with mordenite impurities and less crystalline than synthesis at 150 °C. Keywords: ZSM-5, dealuminated metakaolin, without organic  templates, temperature and time settings
4-ETOKSI-3-METOKSIFENOL DAN METIL-3,4-DIHIDROKSIBENZOAT, DUA SENYAWA TURUNAN FENOLIK DARI EKSTRAK ETIL ASETAT KULIT UMBI GADUNG (Dioscorea hispida Dennst) DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT
Authors: Aminah Nanik Siti , Kristanti Alfinda Novi , Labibah Qonitah , Firdausyah Ana , Takaya Yoshiaki
Published: October 2019

Two phenolic compoundnamely 4-ethoxy-3-methoxyphenol and methyl-3,4-dihydroxybenzoic have been isolated fromDioscorea hispida Dennst. The isolation of phenolic compounds was done by maceration methods using methanol, followed by partition with n-hexane and ethyl acetate. The process of separation and purification used various chromatography techniques including vacuum liquid chromatography, column chromatography, and radial chromatography. The structure of isolated compounds were determined by spectroscopic methods including UV-Vis, IR, 1D and 2D NMR. The ethyl acetate extract was evaluated for DPPH free radical scavenging activity assay. The IC50of ethyl acetate extract was 415 ppm. The result of this assay indicated that ethyl acetate extract has a potential as an antioxidant.  Keywords: Dioscorea hispida Dennst, Dioscoreaceae, phenolic, 4-ethoxy-3-methoxyphenol, methyl-3,4-dihydroxybenzoic, and antioxidant
BIODEGRADASI ZAT WARNA ACID ORANGE 7 MENGGUNAKAN ENZIM JAMUR TIRAM PUTIH (PLEUROTUS OSTREATUS)
Authors: Amiruddin Achmad , Hasri Hasri , Sudding Sudding
Published: October 2019

Synthetic dyes is most be usedin the textile industry because it is stable, easy to obtain, and cheap,the waste, however,is difficult to degrade, so it can cause contaminants in the waters and disrupt the aesthetics of water bodies. One of the alternative and environmentally-friendly methods that can be used to degrade dyestuff waste prior to discharge into the waters is by utilizing microorganisms as degrading agents. Therefore, this study aims to determine the ability of P.ostreatus fungus enzymes in degrading acid orange dyes 7 based on the variation of degradation time. The results showed that P.ostreatus fungus enzyme was able to degrade the orange acid 7 until 59.36%  Keywords: degradation, acid orange 7, white oyster mushroom (P.ostreatus)
SKOPOLETIN SUATU SENYAWA FENILPROPANOID DARI EKSTRAK ETIL ASETAT UMBI UBI JALAR (Ipomoea batatas L.)
Authors: Aminah Nanik Siti , Isma Choirotul , Kristanti Alfinda Novi
Published: October 2019

AbstrakTelah berhasil diisolasi senyawa golongan fenil propanoid  dengan nama “skopoletin” dari ekstrak etil asetat  umbi Ubi Jalar (Ipomoea batatas L.). Ekstraksi senyawa fenolik dilakukan dengan metode maserasi menggunakan pelarut metanol, dilanjutkan partisi menggunakan n-heksana dan etilasetat. Pemurnian dilakukan dengan kromatografi kolom gravitasi dan ktomatografi radial menghasilkan senyawa golongan fenil propanoid. Struktur skopoletin diidentifikasi berdasarkan data spektrum UV, 1D dan 2D NMR.Kata kunci : fenil propanoid, skopoletin, dan Ipomoea batatas L. AbstractPhenylpropanoid group compound has been isolated as “scopoletin” from ethylacetate extract of tuber flesh Sweet potatoes (Ipomoea batatas L.). Extraction of phenolic compound was done by maceration method using methanol solvent, then partition with n-hexana and  ethylacetate, respectively. The process of purification using various chromatographic techniques yielded compound of phenylpropanoid group. Structure of scopoletin is identified based on UV, 1D, and 2D NMR spectra.Keyword  : phenyl propanoid, scopoletin, dan Ipomoea batatas L.
ISOLATION AND IDENTIFICATION OF SECONDARY METABOLITES OF BLACK BETEL (Piper betle L. var Nigra)
Authors: Junairiah Junairiah , Ni’matuzahroh Ni’matuzahroh , Zuraidassanaaz Nabilah Istighfari , Sulistyorini Lilis
Published: October 2019

AbstractPiper betle L. var Nigra commonly known as black betel have a potential as drug raw materials. The leave of black betel  can be used to resist bleeding so as to accelerate the healing of wounds on the skin, sputum, other uses are for epistaxis, as well as for dialysis, asthma, bronchitis, cough, and high blood pressure. Many uses of black betel leaves make it interesting to learn its metabolites compounds by phytochemical screening. So, this research aimed  to isolate and identificate secondary metabolites of Piper betle L. var Nigra. This research used three kind of organic solvents, there were methanol, ethyl acetate, and n-hexane. Several screening tests were used to isolate and identificate the phytochemical compound, including screening of alkaloids, terpenoids/steroids, flavonoids, polyphenols, tannins, and saponins. The results showed that methanol extract of black betel leaves contained of alkaloids, terpenoids/steroid, flavonoids, polyphenols and tannins compounds. The ethyl acetate extract of black betel leaves contained of terpenoids/steroid, flavonoids and tannins compounds. The n-hexane extract of black betel leaves contained of terpenoids/steroid. The methanol extract of Piper betle L. var Nigra contained more secondary metabolites than n-hexane and ethyl acetate extracts. Keywords : methanol ; Phytochemical screening ; Piper betle L. var Nigra.
Evaluasi Pemberian Unsur Hara Besi pada Kandungan Asam Amino dan Mineral dalam Biji Jagung
Authors: Saprudin Deden , Palupi Citra Ajeng , Rohaeti Eti
Published: October 2019

Evaluasi pemberian pupuk nanomagnetit (Fe3O4) 25 ppm dan pupuk komersial Fe-kelat 250 ppm terhadap kandungan nutrisi dalam biji jagung seperti kandungan proksimat, asam amino, serta mineral telah dilakukan. Asam amino ditentukan menggunakan kromatografi cair kinerja tinggi (KCKT) dan mineral ditentukan menggunakan spektrofotometri serapan atom (SSA). Pengolahan data melalui uji anova satu arah untuk membandingkan kedua jenis perlakuan. Perlakuan Fe-kelat 250 ppm dapat meningkatkan kandungan total asam amino 32% dan total mineral 86%. Begitupun perlakuan nanomagnetit 25 ppm juga terbukti meningkatkan kandungan total asam amino sebesar 18% dan total mineral 29% pada biji jagung secara signifikan jika dibandingkan dengan kontrol berdasarkan uji anova.
PEMURNIAN PARSIAL EKSTRAK KASAR SELULASE BACILLUS CIRCULANS DENGAN METODA PENGENDAPAN ASETON
Authors: Sabilla Iqbal Achmad , Susanti Evi
Published: October 2019

AbstrakTujuan penelitian ini adalah untuk mengetahui tingkat kemurnian hasil pengendapan ekstrak kasar selulase Bacillus circulans pada berbagai kejenuhan aseton;   pengaruh waktu pengendapan terhadap tingkat kemurnian hasil pengendapan pada kejenuhan aseton optimum; dan stabilitas waktu penyimpanan fraksi optimum pada suhu 0°C selama 0,1,4 dan 7 hari.Aktivitas selulase diukur berdasarkan kenaikan kadar gula pereduksi yang dihasilkan pada substrat kertas Whatman no 1. Penentuan kadar gula pereduksi menggunakan metode Somogy-Nelson. Kadar protein ditentukan dengan metode Lowry. Tingkat kemurnian enzim merupakan perbandingan aktivitas spesifik enzim setelah pemurnian dengan sebelum pemurnian.Tingkat kemurnian hasil pengendapan ekstrak kasarBacillus circulans mengalami peningkatan pada kejenuhan aseton ( 33 %), (41,1 %) dan (50 %) kemudian menurun pada kejenuhan (60 %) dan (67 %). Fraksi yang aktivitas spesifik tertinggi adalah pada tingkat kejenuhan aseton 50 %, dengan tingkat kemurnian rata-rata 63,61 ± 0,141 kali ekstrak kasar dan perolehan protein kembali rata-rata 76,85 ± 7,99 %. Waktu pengendapan tidak berpengaruh terhadap tingkat kemurnian hasil pengendapan ekstrak kasar selulase Bacillus circulans pada kejenuhan aseton optimum.Selulase hasil pengendapan dengan aseton memiliki stabilitas yang kurang baik pada suhu ± 0°C karena menurun sebesar 41,1 % pada hari pertama dan 88,2 % pada hari ketujuh setelah penyimpanan. Kata kunci: selulase, Bacillus circulans, pengendapan, aseton.    AbstractThe aims of this study were to determine the purity level of precipitations of  cellulases of Bacillus circulans at various saturation of acetone; the effect of precipitation time on the purity level of the precipitations at optimum acetone saturation; and the stability of the storage time of the optimum fraction at 0 ° C for 0,1,4 and 7 days. The activity of cellulase was measured based on the increased of reducing sugar levels produced from hydrolysed of Whatman paper as substrate. The reducing sugar levels were determined with  the Somogy-Nelson method. Protein levels are determined with the Lowry method. The purity level of the enzyme is a comparison of specific enzyme activity after and before purification. The purity level of precipitations of cellulose of Bacillus circulans has increased in saturation of acetone (33%), (41.1%) and (50%) then decreases in saturation (60%) and (67%). The highest cellulase specific activity fraction was at 50% acetone saturation level, with an average purity level of 63.61 ± 0.141 times crude extract and yield protein recovery an average of 76.85 ± 7.99%. The precipitation time did not affect the purity level of the precipitations at optimum acetone saturation. The precipitations had low storage stability at ± 0 oC because its cellulase activity decreased by 41.1% on the first day and  88.2 % on the seventh day after storage The keywords: cellulose, Bacillus circulans, precipitation, aceton
What Drives Stock Market Performance of Banks / Universal Banks? A Critical Examination of Literature
Authors: Dayag Antonio Jaramillo , Trinidad Fernando L.
Published: October 2019

Universal banks combine commercial loan services and public deposit functions with investment, and other services such as home and auto financing, mutual funds, pension and insurance to name a few. The importance of universal banks have been recognized in emerging economies, and its growth spur economic growth and development of many countries in the world. Most universal banks are listed in stock exchanges, and as financial intermediaries, not only these banks expand their already wide portfolios but they allow more global investors into the fold, almost like a foreign direct investor, the difference only is, the investor don’t have to leave the home country. Since these banks are considered to be among the key players in stock markets, and this study seeks to understand what factors drive their performance in stock exchange so that global investors be aided in making investment decisions on universal banks.
PRODUÇÃO DE SERAPILHEIRA SOB PLANTIO DE HÍBRIDOS DE Eucalyptus, ALIANÇA DO TOCANTINS - TOCANTINS
Authors: Teixeira Paulo Ricardo , Souza Rômullo Quirino de , Camargo Marilia Oliveira , Tavares Rodrigo de Castro , Souza Priscila Bezerra de
Published: October 2019

O objetivou-se verificar a produção de serapilheira sob dois plantios E. urocam e E. urograndis, inseridos no domínio Cerrado, Aliança do Tocantins – TO. O estudo foi desenvolvido na fazenda Nossa Senhora Parecida, Aliança do Tocantins – TO, sob as coordenadas 11”21’53 S e 49”02’54 O. Foram instalados aleatoriamente em cada um dos plantios dez coletores de 1 x 1 m. Os coletores foram sustentados por estacas com 0,80 m de altura do solo, os quais foram monitorados mensalmente durante o período de maio 2015 a abril de 2016. As amostras coletadas foram secas e separadas em frações de folha e material lenhoso. A produção média de serapilheira total entre os dois plantios apresentou-se bem variável com uma produção anual de 3274,5 kg ha-1 no plantio de E. urocam e de 3523 kg ha-1 no plantio de E. urograndis. A fração mais representativa da serapilheira total encontrada nos dois plantios estudados foi composta por folhas, que perfazem 51,2% do total de material depositado nos coletores enquanto que a fração material lenhoso contribuiu com 48,8%. Em ambos os plantios o maior aporte de folhas ocorreu no período de maior precipitação (maio, novembro e dezembro de 2015 e janeiro a abril de 2016).
COMMUNITY-BASED EDUCATION PROGRAM ON KNOWLEDGE AND SELF-EFFICACY OF TYPE 2 DIABETES MELLITUS’ PATIENTS IN BANDUNG
Authors: Sari Citra Windani Mambang , Yamin Ahmad , Santoso Mochmad Budi
Published: October 2019

Introduction. Type 2 Diabetes Mellitus was a chronic disease have complicated. Amount of patient Type 2 Diabetes Mellitus (DM) was increased. Knowledge and self-efficacy is mainly important for self-care behavior. The purpose of this study was aimed to examine knowledge, and self-efficacy among patients with Type 2 DM in Bandung, Indonesia. Methods. The research was a quasi-experimental with pre and posttest control group. Sixty two type 2 DM were recruited from 8 working area Primary Health Centers in Bandung who have diagnosed DM, using purposive sampling technique. Knowledge questionnaire from Michigan Diabetes Research and Training Center’s Brief Diabetes Knowledge Test, Self-efficacy were measured by the developed Stanford Patients Education Research Center. Both of questionnaires comprised five dimensions: nutrition, sport and activity, drugs and glucose monitoring. Patients of in intervention group received 2 weeks Diabetes Mellitus education program be given healthcare workers. Techniques used in this program consisted of community-based education, goal setting, follow-up and face-to-face interview. Data were analyzed by independent t-test. Results. There are significantly different of knowledge and self-efficacy after community-based education program in intervention (M = 9.26, SD = 2.8 ; M = 53.26, SD = 10.50) and control group (M = 7.39, SD = 2.4; M = 36.74, SD = 4.49).  This study revealed that community-based education program significantly improved self-efficacy (p=0.000) but not improved for knowledge (p=0.180). Conclusion. These findings indicated that Knowledge and Self-efficacy of type 2 Diabetes Mellitus patients in Bandung required improvement. Therefore, further study regarding the effective in improving knowledge and self-efficacy type 2 Diabetes Mellitus is extremely needed.
Mosquito Nests Eradication through Monitoring the Mosquito Larva (Jumantik) by School Children in Preventing the Dengue Hemorrhagic Fever
Authors: Jafar Nuurhidayat , Fadilah Nur , Malasari Silvia , Sangkala Moh Syafar , Setyawati Andina , Wahyuni Andi
Published: October 2019

Background: Dengue Hemorrhagic Fever (DHF) is still a major health problem in Indonesia. Community participation is a key component of DHF control. The group of schoolchildren is part of a group of people who can play a strategic role, considering the number is very much around 20% of the population. Through this Jumantik, the elementary school children are trained as a mosquito larva (jumantik) in their school. Objective: Establishment of larva monitoring group (Jumantik) and implementation of mosquito nest eradication activity at home and at school Method: A community service activity is conducted by recruiting and providing the training for Jumantik School Children and the teachers. Before the training, the students were given with the pre-test. After the training, the students followed the post-test and were given the mosquito eradication kit to undertake the mosquito larva monitoring at school and home. Result: As much as nine elementary students and three teachers were formed as jumantik volunteers from three different elementary schools namely Malewang, Palleko and Pangembang . The result of pre-test of 9 students, the average score of 8.67 (maximum points 15) with the highest score 11 and the lowest score 6. While the post test results obtained an average value of 11, 89 with the highest value 14 and the lowest value 10. The forms of activity for this program were: establishment of Jumatik school children, distribution of mosquito eradication kit, distribution of leaflet and stickers as the media of health promotion, provision of certificate of training of Jumantic school children and the teachers, the establishment of Plan of Action (POA) of the program and the production of second-hand good products. Conclusion and Suggestion: There are six activities that was implemented in this community service activity. It is suggested that the school to carry out routine activities according to the POA that has been agreed and the community health center can supervise the activity undertaken by the Jumantik school children. Keywords: Jumantik, Dengue Hemorrhagic Fever, school children, mosquito eradication
Effect Of Long Term Inhaled Corticosteroid Therapy On Adrenal Suppression, Growth And Bone Health In Children With Asthma
Authors: Anuradha K W D A , Prematilake G L D C , Batuwita B A U I , Kannangoda KASR , Hewagamage U S , Wijeratne S , Lankatilake Kantha , de Silva KSH
Published: October 2019

Abstract
Background
Inhaled corticosteroids(ICS) are the most effective treatment for children with persistent asthma .However adverse effects of ICS on Hypothalamo Pituitary Adrenal (HPA) axis, growth and bone metabolism are a concern. Hence the primary objective of this study was to describe the effects of long term inhaled corticosteroid therapy (ICS) on adrenal function, growth and bone health in children with asthma in comparison to an age and sex matched group of children with asthma who were not on long term ICS. .Describing the association between the dose of ICS and duration of therapy on the above parameters were secondary objectives.
Method
Seventy children with asthma on ICS and 70 controls were studied. Diagnosis of asthma in selected patients was reviewed according to the criteria laid down by GINA 2018 guidelines .The estimated adult heights were interpreted relative to their Mid Parental Height (MPH) range. Serum calcium, alkaline phosphatase and vitamin D levels were analyzed in both groups and cortisol value at 30 minutes following a low dose short synacthen test was obtained from the study group. The average daily dose of ICS (Beclamethasone) was categorized as low, medium and high (100-200, 200-400, >400 ug /day) respectively according to published literature.
Results
Heights of all children were within the MPH range. There was no statistically significant difference in the bone profiles and vitamin D levels between the two groups (Ca: p=0.554, vitamin D: p=0.187) but vitamin D levels were insufficient (<50 nmol/l) in 34% of cases and 41% of controls. Suppressed cortisol levels were seen in 24%. Doses of ICS were low, medium and high in 56%, 32% and 12% of children respectively. The association between adrenal suppression with longer duration of therapy (p<0.01) and with increasing dose of ICS (p<0.001) were statistically significant.
Conclusion
ICS had no impact on the growth and bone profiles but its dose and duration were significantly associated with adrenal suppression.
Key Words- Asthma, Inhaled corticosteroids, Growth, Adrenal suppression, Bone Metabolism, Vitamin D
Youth StepCare: A pilot study of an online screening and recommendations service for depression and anxiety among youth patients in general practice.
Authors: Parker Belinda , Achilles Melinda Rose , Subotic-Kerry Mirjana , O'Dea Bridianne
Published: October 2019

Background: General Practitioners (GPs) are ideally placed to identify and manage emerging mental illness in young people, however, many report low levels of confidence in doing so. A web-based universal screening service delivered via a mobile tablet, Youth StepCare, was developed to assist GPs in identifying depression and anxiety symptoms in youth patients. The service also provided evidence-based treatment recommendations and fortnightly monitoring of symptoms. The current study assessed the feasibility and acceptability of delivering the Youth StepCare service in Australian general practices. Methods: A 12-week uncontrolled trial was undertaken between August 2018 and January 2019 in two general practices in NSW, Australia. The service was offered to all youth patients aged 14-17 years who visited their participating GP during the screening period alongside their parent or guardian. Youth patients reported the presence of depressive and anxiety symptoms using the self-report Patient Health Questionnaire-9 and the Generalised Anxiety Disorder Questionnaire-7. New cases were defined as those who were experiencing symptoms and were not currently visiting their GP, nor had previously sought help for mental health issues. Feasibility and acceptability of the service among GPs and practice staff was assessed using a battery of questionnaires. Results: Five GPs and 6 practice staff participated in the trial. A total of 46 youth patients were approached and 28 consented to participate. Of these, 19 completed the screener (67.9%). Nine reported symptoms of anxiety or depression, two of which were new cases (22.2%). GPs and practice staff were satisfied with the service, reporting that there was a need for the service, and that they would use it again. Conclusions: The Youth StepCare service appears to be a useful tool for identifying youth with unidentified symptoms of mental illness that can be easily embedded into general practice. Further research would benefit from exploring the factors affecting initial GP uptake and a larger trial is required to determine the efficacy of the service on young people’s symptom reduction.
Latent Dirichlet Allocation in Predicting Clinical Trial Terminations
Authors: Geletta Simon , Follett Lendie , Laugerman Marcia R
Published: October 2019

Background : This study used natural language processing (NLP) and machine learning (ML) techniques to identify reliable patterns from within research narrative documents to distinguish studies that complete successfully, from the ones that terminate. Recent research findings have reported that at least ten percent of all studies that are funded by major research funding agencies terminate without yielding useful results. Since it is well-known that scientific studies that receive funding from major funding agencies are carefully planned, and rigorously vetted through the peer-review process, it was somewhat daunting to us that study-terminations are this prevalent. Moreover, our review of the literature about study terminations suggested that the reasons for study terminations are not well understood. We therefore aimed to address that knowledge gap, by seeking to identify the factors that contribute to study failures.

Method : We used data from the clinicialTrials.gov repository, from which we extracted both structured data (study characteristics), and unstructured data (the narrative description of the studies). We applied natural language processing techniques to the unstructured data to quantify the risk of termination by identifying distinctive topics that are more frequently associated with trials that are terminated and trials that are completed. We used the Latent Dirichlet Allocation (LDA) technique to derived 25 “topics” with corresponding sets of probabilities, which we then used to predict study-termination by utilizing random forest modeling. We fit two distinct models – one using only structured data as predictors and another model with both structured data and the 25 text topics derived from the unstructured data.

Results : In this paper, we demonstrate the interpretive and predictive value of LDA as it relates to predicting clinical trial failure. The results also demonstrate that the combined modeling approach yields robust predictive probabilities in terms of both sensitivity and specificity, relative to a model that utilizes the structured data alone.

Conclusions : Our study demonstrated that the use of topic modeling using LDA significantly raises the utility of unstructured data in better predicating the completion vs. termination of studies.
VES-13 Role to Identify Limited Life Expectancy in Older Adults in Primary Care Settings
Authors: Assis Danilo Lopes , Chagas Virginia Oliveira , Santos Helton Saulo Bezerra dos , Suemoto Cláudia Kimie , Santana Alfredo Nicodemos Cruz
Published: October 2019

Background: Population aging is a phenomenon that represents a challenge to the health systems, especially to settings with limited economic resources. In this scenario, it is essential to perform adequate screening, diagnostic, and therapeutic approaches to reduce health vulnerability. To investigate, for the first time, the potential role of Vulnerable Elders Survey (VES-13) to identify older adults with Limited Life Expectancy (LLE) (defined as estimated 10-year mortality risk ≥ 50%) in Primary Health Care (PHC) settings. Methods: This cross-sectional study was performed in all PHC units in Jatai (Brazil) from July to December 2018. The sample size of 407 elderly individuals was obtained considering an older population (≥60 years old) of 10,853, a 50% prevalence, a 5% margin of error, a 95% confidence level, and 10% of possible losses. Participants answered a questionnaire about sociodemographic and clinical characteristics, including the VES-13 (a tool to identify health vulnerability) and the Suemoto index (an index to estimate 10-year mortality risk for community-dwelling older adults). We tested the association between LLE and VES-13, using multiple logistic regression analysis. In addition, we investigated the discrimination of the VES-13 in identifying individuals with LLE using the area under the receiver operator characteristic curve (AUROC). Results: The mean age was 68.9 ± 6.6yo, and 58% were women. The mean score of VES-13 was 2.0 ± 2.2, the mean score of Suemoto index was 31.5 ± 21.1%, and 17.2% had LLE. The VES-13 was associated with LLE (OR=1.57; p=<0.0001). Moreover, a VES-13 score ≥2 points was able to discriminate LLE (AUROC=0.764 (95%CI=0.078-0.820); sensitivity 81%). Conclusion: VES-13was able to identify older adults with LLE in PHC settings. Thus, the VES-13 could play a role in detecting older adults that would not benefit from screening (e.g., colorectal cancer) and strict control of chronic diseases (e.g., diabetes). However, other longitudinal studies are needed to confirm the role of VES-13 in identifying older adults with LLE, before the VES-13 can be adopted in routine clinical practice decisions in PHC, since we used a prediction model to identify LLE.