bluuebunny/crossref_metadata_2025 huggingface dataset:
Heterogeneous Responses to Changes in Inhibitory Synaptic Strength in Networks of Spiking Neurons
Authors: Li H. Y. , Cheng G. M. , Ching Emily S. C.
Published: February 2022

How does the dynamics of neurons in a network respond to changes in synaptic weights? Answer to this question would be important for a full understanding of synaptic plasticity. In this article, we report our numerical study of the effects of changes in inhibitory synaptic weights on the spontaneous activity of networks of spiking neurons with conductance-based synapses. Networks with biologically realistic features, which were reconstructed from multi-electrode array recordings taken in a cortical neuronal culture, and their modifications were used in the simulations. The magnitudes of the synaptic weights of all the inhibitory connections are decreased by a uniform amount subjecting to the condition that inhibitory connections would not be turned into excitatory ones. Our simulation results reveal that the responses of the neurons are heterogeneous: while the firing rate of some neurons increases as expected, the firing rate of other neurons decreases or remains unchanged. The same results show that heterogeneous responses also occur for an enhancement of inhibition. This heterogeneity in the responses of neurons to changes in inhibitory synaptic strength suggests that activity-induced modification of synaptic strength does not necessarily generate a positive feedback loop on the dynamics of neurons connected in a network. Our results could be used to understand the effects of bicuculline on spiking and bursting activities of neuronal cultures. Using reconstructed networks with biologically realistic features enables us to identify a long-tailed distribution of average synaptic weights for outgoing links as a crucial feature in giving rise to bursting in neuronal networks and in determining the overall response of the whole network to changes in synaptic strength. For networks whose average synaptic weights for outgoing links have a long-tailed distribution, bursting is observed and the average firing rate of the whole network increases upon inhibition suppression or decreases upon inhibition enhancement. For networks whose average synaptic weights for outgoing links are approximately normally distributed, bursting is not found and the average firing rate of the whole network remains approximately constant upon changes in inhibitory synaptic strength.
Neonatal Feeding Tube Colonization and the Potential Effect on Infant Health: A Review
Authors: Parker Leslie A. , Magalhães Marina , Desorcy-Scherer Katelyn , Torrez Lamberti Monica , Lorca Graciela L. , Neu Josef
Published: February 2022

Background

Infants in the neonatal intensive care unit (NICU) often require feeding tubes (FT) for weeks to months. Because FTs are in near constant contact with human milk and/or formula, rapid and extensive bacterial growth is possible. Due to their immature immunologic and gastrointestinal (GI) systems, infants may be at significant health risk due to FT colonization. In adults, length of time FTs remain in place (dwell time) affects the degree of colonization and biofilm formation which is important in infants whose tubes remain in place up to 30 days.

Objective

The purpose of this review was to describe and summarize the evidence regarding FT bacterial colonization in infants and identify gaps needing further investigation.

Methods

Medline, CINAHL, and Embase databases were searched for clinical and/or laboratory-based observational and randomized controlled studies investigating the presence of bacteria in neonatal FTs.

Results

This review of 10 studies found evidence that neonatal FTs may contain high quantities of potentially pathogenic and antibiotic resistant bacteria and longer dwell times may increase the bacterial load. Furthermore, evidence suggests FT colonization may be nosocomial in origin and contribute to adverse infant health. Feeding tubes are an unrecognized source of bacterial colonization which may increase morbidity in premature infants and thus the presence of bacteria in FTs is an important area of investigation in the nutritional care of vulnerable infants in the NICU.

Implications

Further appropriately powered studies which are clinically based, use appropriate analyses, and control for potential covariates are necessary to make clinical recommendations.
An Up-To-Date Investigation Into the Correlation Between Proton Pump Inhibitor Use and the Clinical Efficacy of Immune Checkpoint Inhibitors in Advanced Solid Cancers: A Systematic Review and Meta-Analysis
Authors: Liu Chaoxing , Guo Huaijuan , Mao Haiyan , Tong Jiandong , Yang Mengxue , Yan Xuebing
Published: February 2022

Background

Although immune checkpoint inhibitors (ICIs) have revolutionized the current anticancer therapies, a considerable proportion of patients are found to hardly benefit from these drugs. Accumulating studies have demonstrated that concomitant proton pump inhibitor (PPI) use may affect the clinical efficacy of ICIs; however, their results are inconsistent. In this study, based on updated evidence, we aimed to perform a meta-analysis to clarify the prognostic significance of PPI use in advanced solid cancer patients receiving ICI therapy.

Methods

Eligible literature was searched using PubMed, Cochrane Library, Web of Science, EMBASE, and other network resources before July 2021. Clinical outcome was evaluated using overall survival (OS) and progression-free survival (PFS). The correlation of PPI use with OS or PFS was determined based on hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

A total of 17 studies enrolling 9,978 ICI-treated cancer patients were included in our meta-analysis. The global analysis demonstrated that PPI use was significantly correlated with worse OS [HR = 1.29 (1.10–1.50)] instead of PFS [HR = 1.19 (0.98–1.44)] in solid cancer patients receiving ICI therapy. In a subgroup analysis, the negative correlation of PPI use with ICI efficacy was significant in patients with non-small cell lung cancer [PFS, HR = 1.27 (1.10–1.47)] and urothelial carcinoma [OS, HR = 1.55 (1.31–1.84), PFS, HR = 1.52 (1.13–2.06)] and mixed cohorts containing multiple cancer types [OS, HR = 1.40 (1.16–1.69)], while an opposite result was observed in the PFS of patients with melanoma [HR = 0.48 (0.25–0.90)]. Moreover, the unfavorable prognostic impact of PPI use was also significant in patients over 65 years old [OS, HR = 1.28 (1.05–1.55), PFS, HR = 1.32 (1.12–1.56)] or those receiving anti-PD-1 [OS, HR = 1.37 (1.04–1.79)] or anti-PD-L1 therapies (OS, HR = 1.49 (1.30–1.69), PFS, HR = 1.34 (1.20–1.50). Finally, PPI use was significantly correlated with a worse prognosis in patients receiving PPIs 30 days before and/or after ICI initiation (OS, HR = 1.38 (1.18–1.62), PFS, HR = 1.23 (1.06–1.43)).

Conclusion

Although our global analysis revealed PPI use was not correlated with the PFS of ICI-treated patients, considering the results of our subgroup analysis, PPIs should be still cautiously used shortly before or during ICI therapy. Furthermore, more clinical validations and related mechanism investigations are of great necessity to clarify the clinical correlation of PPI use with ICI efficacy.

Systematic Review Registration

[https://www.crd.york.ac.uk/prospero/], PROSPERO [No. CRD42021243707].
Predicting Distant Metastasis in Young-Onset Colorectal Cancer After Surgery: A Retrospective Study
Authors: Cheng Jie , Lao Yao-Jia , Wang Qian , Huang Kai , Mou Juan-Li , Feng Jia-Hui , Hu Fan , Lin Meng-Lu , Lin Jun
Published: February 2022

Background

Although overall colorectal cancer (CRC) cases have been declining worldwide, there has been an increase in the incidence of the CRC among individuals younger than 50 years old, which is associated with distant metastasis (DM) and poor prognosis.

Methods

Young-onset CRC patients’ postoperative data were collected from the Surveillance, Epidemiology, and End Results (SEER) database between January 2010 and December 2015. Data from the SEER database were divided into early stage and advanced stage according to whether chemoradiotherapy was recommended in the guidelines. Independent risk factors for DM were explored by using univariate and multivariate logistic regression separately. A predictive model was established and presented as nomogram in the training set of advanced stage. The model was internally verified in testing set and externally validated in a cohort of 145 patients from Zhongnan Hospital of Wuhan University. The accuracy, reliability, and clinical application value were assessed using the receiver operating characteristic curve (ROC), the area under the curve (AUC), calibration curve, and decision curve analysis (DCA), respectively. Different risk subgroups of DM were classified according to the scores of the nomogram in the training set of advanced stage.

Results

A total of 5,584 patients were eligible and enrolled in our study in which 1,277 were in early stage and 4,307 in advanced stage. Preoperative CEA positive was found to be an independent predictor of DM in early stage. Multivariate logistic regression analysis showed that tumor size, degree of differentiation, T stage, N stage, preoperative CEA, and whether radiation or chemotherapy performed were independent risk factors for DM (all, p < 0.05) in advanced stage. Great accuracies were achieved in our nomogram with AUC of 0.801 in training set, 0.811 in testing set, and 0.791 in the validation cohort, respectively. Calibration curves and DCA in internal validation and external validation both showed good stability and clinical utility values.

Conclusions

Preoperative CEA positive was a significant predictor of DM for young-onset CRC patients. A novel nomogram containing clinical and pathological features was established for predicting DM of advanced CRC in patients younger than 50 years old. This tool may serve as an early alert for clinicians to DM and make better clinical treatment regimens.
Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing
Authors: Yin Hua , Hong Mei , Deng Jun , Yao Lan , Qian Chenjing , Teng Yao , Li Tingting , Wu Qiuling
Published: February 2022

Background

Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignant tumor with poor prognosis. However, accurate prognostic stratification factors are still unclear.

Methods

Data from 90 adult T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients were collected. The association of gene mutations detected by next-generation sequencing and clinical characteristics with the outcomes of T-ALL/LBL patients were retrospectively analyzed to build three novel risk stratification models through Cox proportional hazards model.

Results

Forty-seven mutated genes were identified. Here, 73.3% of patients had at least one mutation, and 36.7% had ≥3 mutations. The genes with higher mutation frequency were NOTCH1, FBXW7, and DNMT3A. The most frequently altered signaling pathways were NOTCH pathway, transcriptional regulation pathway, and DNA methylation pathway. Age (45 years old), platelet (PLT) (50 G/L), actate dehydrogenase (LDH) (600 U/L), response in D19-BMR detection, TP53 and cell cycle signaling pathway alterations, and hematopoietic stem cell transplantation (HSCT) were integrated into a risk stratification model of event-free survival (EFS). Age (45 years old), white blood cell (WBC) count (30 G/L), response in D19-BMR detection, TP53 and cell cycle signaling pathway alterations, and HSCT were integrated into a risk stratification model of overall survival (OS). According to our risk stratification models, the 1-year EFS and OS rates in the low-risk group were significantly higher than those in the high-risk group.

Conclusions

Our risk stratification models exhibited good prognostic roles in adult T-ALL/LBL patients and might guide individualized treatment and ultimately improve their outcomes.
Health-Related Quality of Life in Children With Kaposiform Hemangioendothelioma
Authors: Dai Shiyi , Yang Kaiying , Qiu Tong , Zhou Jiangyuan , Zhang Xuepeng , Chen Siyuan , Li Lizhi , Ji Yi
Published: February 2022

Background and Objective

Kaposiform hemangioendothelioma (KHE) is a rare, aggressive and borderline vascular tumor mainly occurring in infants and children. The aim of this study was to determine the health-related quality of life (HRQOL) in children with KHE.

Measures

A total of 91 children with KHE participated in this cross-sectional study. The HRQOL was assessed by the age-specific Pediatric Quality of Life Inventory Version 4.0 (PedsQL™ 4.0) Infant Scales, Family Information Form (FIF), Family Impact Module (FIM) and Generic Core Scales (GCS). For comparison, demographically matched healthy children were recruited as a control group. The main outcome measure of HRQOL was analyzed in the two groups. We determined related factors that influenced the HRQOL in children with KHE and their parents by using a stepwise multiple regression analysis.

Results

The study found that the scores of each item in the family impact module (FIM) were lower than 75, which suggesting that KHE can make the parents of patients in a state of poor quality of life. The scores of physiological and psychosocial domains in all age groups of patients with KHE were lower than those of normal children (P < 0.01). Activity dysfunction is the factor influencing the physiological function score of all-age patients. KMP is the factor influencing the psychosocial function score of all-age patients.

Conclusions

The findings presented here suggest that patients with KHE have a poor HRQOL. KMP and activity dysfunction are risk factors for poor HRQOL in patients with KHE. However, lesion size, lesion location and education level of the mother and father were not related to the HRQOL.
Artificial Intelligence–Assisted Bone Age Assessment to Improve the Accuracy and Consistency of Physicians With Different Levels of Experience
Authors: Wang Xi , Zhou Bo , Gong Ping , Zhang Ting , Mo Yan , Tang Jie , Shi Xinmiao , Wang Jianhong , Yuan Xinyu , Bai Fengsen , Wang Lei , Xu Qi , Tian Yu , Ha Qing , Huang Chencui , Yu Yizhou , Wang Lin
Published: February 2022

Background

The accuracy and consistency of bone age assessments (BAA) using standard methods can vary with physicians' level of experience.

Methods

To assess the impact of information from an artificial intelligence (AI) deep learning convolutional neural network (CNN) model on BAA, specialists with different levels of experience (junior, mid-level, and senior) assessed radiographs from 316 children aged 4–18 years that had been randomly divided into two equal sets-group A and group B. Bone age (BA) was assessed independently by each specialist without additional information (group A) and with information from the model (group B). With the mean assessment of four experts as the reference standard, mean absolute error (MAE), and intraclass correlation coefficient (ICC) were calculated to evaluate accuracy and consistency. Individual assessments of 13 bones (radius, ulna, and short bones) were also compared between group A and group B with the rank-sum test.

Results

The accuracies of senior, mid-level, and junior physicians were significantly better (all P < 0.001) with AI assistance (MAEs 0.325, 0.344, and 0.370, respectively) than without AI assistance (MAEs 0.403, 0.469, and 0.755, respectively). Moreover, for senior, mid-level, and junior physicians, consistency was significantly higher (all P < 0.001) with AI assistance (ICCs 0.996, 0.996, and 0.992, respectively) than without AI assistance (ICCs 0.987, 0.989, and 0.941, respectively). For all levels of experience, accuracy with AI assistance was significantly better than accuracy without AI assistance for assessments of the first and fifth proximal phalanges.

Conclusions

Information from an AI model improves both the accuracy and the consistency of bone age assessments for physicians of all levels of experience. The first and fifth proximal phalanges are difficult to assess, and they should be paid more attention.
Biological Functions of Strigolactones and Their Crosstalk With Other Phytohormones
Authors: Wu Fenghui , Gao Yinping , Yang Wenjing , Sui Na , Zhu Jianping
Published: February 2022

Phytohormones are small chemicals critical for plant development and adaptation to a changing environment. Strigolactones (SLs), carotenoid-derived small signalling molecules and a class of phytohormones, regulate multiple developmental processes and respond to diverse environmental signals. SLs also coordinate adjustments in the balance of resource distribution by strategic modification of the plant development, allowing plants to adapt to nutrient deficiency. Instead of operating independently, SL interplays with abscisic acid, cytokinin, auxin, ethylene, and some other plant phytohormones, forming elaborate signalling networks. Hormone signalling crosstalk in plant development and environmental response may occur in a fully concerted manner or as a cascade of sequential events. In many cases, the exact underlying mechanism is unclear because of the different effects of phytohormones and the varying backgrounds of their actions. In this review, we systematically summarise the synthesis, signal transduction, and biological functions of SLs and further highlight the significance of crosstalk between SLs and other phytohormones during plant development and resistance to ever-changing environments.
Modulation of Cross-Language Activation During Bilingual Auditory Word Recognition: Effects of Language Experience but Not Competing Background Noise
Authors: Fricke Melinda
Published: February 2022

Previous research has shown that as the level of background noise increases, auditory word recognition performance drops off more rapidly for bilinguals than monolinguals. This disproportionate bilingual deficit has often been attributed to a presumed increase in cross-language activation in noise, although no studies have specifically tested for such an increase. We propose two distinct mechanisms by which background noise could cause an increase in cross-language activation: a phonetically based account and an executive function-based account. We explore the evidence for the phonetically based account by comparing cognate facilitation effects for three groups of native English listeners (monolinguals, late (L2) learners of Spanish, and heritage Spanish speakers) and four noise conditions (no noise, speech-shaped noise, English two-talker babble, and Spanish two-talker babble) during an auditory lexical decision task in English. By examining word recognition in the dominant language, the role of language control mechanisms is minimized, and by examining three different types of competing noise, the role of energetic vs. informational masking can be assessed. Contrary to predictions, we find no evidence that background noise modulates cross-language activation; cognate facilitation is constant across the four noise conditions. Instead, several indices of word recognition performance are found to correlate with aspects of linguistic experience: (1) The magnitude of the cognate facilitation effect is correlated with heritage listeners’ self-ratings of Spanish proficiency; (2) Overall noise deficits are marginally larger for heritage listeners with lower English vocabulary scores; (3) Heritage listeners’ Spanish self-ratings predict their magnitude of informational masking; (4) For all bilinguals, the degree of masking incurred in both English and Spanish two-talker babble is correlated with self-reported daily exposure to Spanish; and (5) The degree of masking incurred by Spanish babble is correlated with Spanish vocabulary knowledge. The results enrich our understanding of auditory word recognition in heritage speakers in particular and provide evidence that informational masking is most subject to modulation due to variation in linguistic experience. It remains to be seen whether cross-language activation is modulated by noise when the target language is the less dominant one.
A Study on China’s Tobacco Taxation and Its Influencing Factor on Economic Growth
Authors: Zhao Shuang
Published: February 2022

Tobacco is a significant product providing considerable economic benefits to countries worldwide, while its increased consumption causes health and socio-economic losses for smokers and non-smokers. This paper constructs a decomposition system of tobacco taxation: the population aging factor is included in the influencing factors of personal tax, and personal tax revenue is regarded as the product of tax structure, macro tax burden, regional economy, reciprocal aging, and the elderly population. This article conducts an empirical study on the relationship between taxation and economic growth. The estimated coefficients of business tax and corporate income tax are significant at the significance level of 0.1, with a consumption tax and time-variable coefficients reporting a 0.02 level of significance. The T statistic value and the explanatory degree of the variables involved in the model to the explained variables are also very high, reaching more than 95%. We find that increasing the macro tax burden negatively impacts economic growth. Therefore, the study suggests that for fostering the industry’s economic growth, the country needs to ensure the optimal macro tax burden of 17.5%, with different types of taxes influencing economic growth. Personal tax reform should pay attention to the phenomenon of aging, adjust the tax structure to increase personal tax income, provide policy support and guarantee for the elderly labor force, and encourage the re-employment of silver-haired people to alleviate the adverse impact of aging on taxation.
A Systematic and Comparative Review of Behavior Change Strategies in Stress Management Apps: Opportunities for Improvement
Authors: Alhasani Mona , Mulchandani Dinesh , Oyebode Oladapo , Baghaei Nilufar , Orji Rita
Published: February 2022

Stress is one of the significant triggers of several physiological and psychological illnesses. Mobile health apps have been used to deliver various stress management interventions and coping strategies over the years. However, little work exists on persuasive strategies employed in stress management apps to promote behavior change. To address this gap, we review 150 stress management apps on both Google Play and Apple's App Store in three stages. First, we deconstruct and compare the persuasive/behavior change strategies operationalized in the apps using the Persuasive Systems Design (PSD) framework and Cialdini's Principles of Persuasion. Our results show that the most frequently employed strategies are personalization, followed by self-monitoring, and trustworthiness, while social support strategies such as competition, cooperation and social comparison are the least employed. Second, we compare our findings within the stress management domain with those from other mental health domains to uncover further insights. Finally, we reflect on our findings and offer eight design recommendations to improve the effectiveness of stress management apps and foster future research.
Cost-Effectiveness of Sequential Teriparatide/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China
Authors: You Ruxu , Liu Jinyu , Ke Lei , Yu Guangyi , Zhang Yu , Mori Takahiro
Published: February 2022

Objective

We aimed to assess the cost-effectiveness of sequential teriparatide/zoledronic acid relative to zoledronic acid monotherapy for postmenopausal osteoporotic women in China.

Methods

A previously validated Markov microsimulation model was updated to examine the cost-effectiveness of daily subcutaneous teriparatide for 2 years followed by annual intravenous zoledronic acid for 3 years (sequential teriparatide/zoledronic acid), compared with zoledronic acid monotherapy for 3 years in Chinese women with postmenopausal osteoporosis at ages 65, 70, 75, and 80 from the health care payer perspective.

Results

The incremental cost-effectiveness ratios (ICERs) (US dollars [$] per quality-adjusted life-year [QALY]) of sequential teriparatide/zoledronic acid vs. zoledronic acid monotherapy was $173,223/QALY at age 65 years, which was much higher than the pre-determined willingness-to-pay (WTP) threshold of $ 31,512/QALY, and the results were similar at other ages. In one-way sensitivity analyses, the two most impactful parameters were the cost of teriparatide and the residual effects of the medications included in this study. Sequential teriparatide/zoledronic acid became cost-effective at age 80 with the cost of teriparatide reduced by 50%. Without the residual effect, the ICER increased to $257,982/QALY. Probabilistic sensitivity analyses shown that the probabilities of zoledronic acid monotherapy being cost-effective were 100% at a WTP of $31,512/QALY.

Conclusions

Among Chinese women with postmenopausal osteoporosis, sequential teriparatide/zoledronic acid was not cost-effective unless the cost of teriparatide was reduced by 50% only for the participants over 80 years.
Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in Kazakhstan: Findings From Large Study
Authors: Orazumbekova Binur , Issanov Alpamys , Atageldiyeva Kuralay , Berkinbayev Salim , Junusbekova Gulnara , Danyarova Laura , Shyman Zhanmedet , Tashmanova Akmaral , Sarria-Santamera Antonio
Published: February 2022

Type 2 diabetes mellitus (T2DM) is a serious public health problem. A large proportion of patients with T2DM are unaware of their condition. People with undiagnosed T2DM are at a greater risk of developing complications, whereas prediabetes has an elevated risk of becoming T2DM. The aim of this study is to estimate the prevalence of impaired fasting glucose (IFG), undiagnosed and prior-diagnosed T2DM in Kazakhstan. A cross-sectional study was conducted in four geographically remote regions using the WHO STEP survey instrument. The status of T2DM of 4,753 participants was determined using the WHO diagnostic criteria based on fasting plasma glucose (FPG) level. As a result, the survey-weighted prevalence of IFG was 1.9% (95% CI 1.1%; 3.5%) and of T2DM was 8.0% (95% CI 3.8; 15.9). A total of 54% of T2DM have been newly diagnosed with T2DM. Being 55–64 years old (OR = 2.71, 95% CI 1.12; 6.60) and having lowered HDL-C level (OR = 3.72, 95% CI 1.68; 8.23) were found to be independent predictors for IFG. Being older than 45 years, a female (OR = 0.57, 95% CI 0.39; 0.83), having high waist circumference, was associated with newly diagnosed T2DM. Whereas, the age older than 45 years, high waist circumference, and family history of diabetes (OR = 2.42, 95% CI 1.64; 3.54) were associated with preexisting T2DM. This study shows a high prevalence of IFG and a high proportion of newly diagnosed T2DM in Kazakhstan. A series of risk factors identified in the study may be used to strengthen appropriate identification of IFG or undiagnosed patients in healthcare settings to deliver either preventive or therapeutic interventions aimed to reduce the incidence of T2DM or the delay of their complications. Further longitudinal studies are needed to confirm these associations in our population.
Increasing Trends in Mental Health Problems Among Urban Chinese Adolescents: Results From Repeated Cross-Sectional Data in Changsha 2016–2020
Authors: Wu Zhipeng , Wang Biao , Xiang Zhibiao , Zou Zhulin , Liu Zhening , Long Yicheng , Chen Xudong
Published: February 2022

This study performed a repeated cross-sectional analysis to explore possible trends in mental health problems among Chinese adolescents over the years of 2016–2020. A total of 2,837 different seventh-grade students were surveyed in three waves from a junior high school in Changsha city, Hunan province in China (978 in 2016, 949 in 2019, and 910 in 2020) using the Mental Health Inventory of Middle School Students (MMHI-60). The results showed that obsessive-compulsive tendencies, interpersonal sensitivity, depression, anxiety, academic stress, and emotional disturbance problems were significantly increased in surveyed adolescents from 2016 to 2020. Moreover, positive rates of most of these problems were significantly higher in females than males, and were significantly increased in only females. These results highlight the importance of focusing on mental health problems among urban Chinese adolescents, especially among girls.
Dual Energy CT Physics—A Primer for the Emergency Radiologist
Authors: Odedra Devang , Narayanasamy Sabarish , Sabongui Sandra , Priya Sarv , Krishna Satheesh , Sheikh Adnan
Published: February 2022

Dual energy CT (DECT) refers to the acquisition of CT images at two energy spectra and can provide information about tissue composition beyond that obtainable by conventional CT. The attenuation of a photon beam varies depends on the atomic number and density of the attenuating material and the energy of the incoming photon beam. This differential attenuation of the beam at varying energy levels forms the basis of DECT imaging and enables separation of materials with different atomic numbers but similar CT attenuation. DECT can be used to detect and quantify materials like iodine, calcium, or uric acid. Several post-processing techniques are available to generate virtual non-contrast images, iodine maps, virtual mono-chromatic images, Mixed or weighted images and material specific images. Although initially the concept of dual energy CT was introduced in 1970, it is only over the past two decades that it has been extensively used in clinical practice owing to advances in CT hardware and post-processing capabilities. There are numerous applications of DECT in Emergency radiology including stroke imaging to differentiate intracranial hemorrhage and contrast staining, diagnosis of pulmonary embolism, characterization of incidentally detected renal and adrenal lesions, to reduce beam and metal hardening artifacts, in identification of uric acid renal stones and in the diagnosis of gout. This review article aims to provide the emergency radiologist with an overview of the physics and basic principles of dual energy CT. In addition, we discuss the types of DECT acquisition and post processing techniques including newer advances such as photon-counting CT followed by a brief discussion on the applications of DECT in Emergency radiology.
Head and Gaze Orientation in Hemispheric Image Viewing
Authors: Kangas Jari , Špakov Oleg , Raisamo Roope , Koskinen Olli , Järvenpää Toni , Salmimaa Marja
Published: February 2022

Head mounted displays provide a good platform for viewing of immersive 360° or hemispheric images. A person can observe an image all around, just by turning his/her head and looking at different directions. The device also provides a highly useful tool for studying the observer’s gaze directions and head turns. We aimed to explore the interplay between participant’s head and gaze directions and collected head and gaze orientation data while participants were asked to view and study hemispheric images. In this exploration paper we show combined visualizations of both the head and gaze orientations and present two preliminary models of the relation between the gaze and the head orientations. We also show results of an analysis of the gaze and head behavior in relation to the given task/question.
Grooming-Related Concerns Among Companion Animals: Preliminary Data on an Overlooked Topic and Considerations for Animals' Access to Health-Related Services
Authors: McDonald Shelby E. , Sweeney Jessica , Niestat Laura , Doherty Colleen
Published: February 2022

Grooming is an essential health maintenance activity that is fundamental to the welfare of many companion animals. Despite the potentially serious consequences of inadequate grooming for pets and their caregivers, few studies have examined the role of access to pet grooming services and supplies in promoting and maintaining companion animal health and welfare. The goal of this paper was 2-fold: (1) To provide preliminary findings demonstrating the scope of grooming and matting concerns among animals served by a large, non-profit animal welfare organization and (2) to provide a call for research to guide effective prevention of and responses to grooming-related omissions of care. We retrospectively extracted data from five American Society for the Prevention of Cruelty to Animals (ASPCA) programs serving the New York City area: ASPCA Animal Hospital (AAH), Community Medicine (CM), One ASPCA Fund, ASPCA-NYPD (New York City Police Department) Partnership, and the Community Engagement (CE) Program. The prevalence of grooming–related concerns was relatively consistent across all three veterinary service programs (AAH: 6%; CM: 4%; One ASPCA Fund: 6%). Thirteen percent of the ASPCA-NYPD Partnership's cruelty cases involved general hair matting concerns and/or strangulating hair mat wounds (93% were long-haired dog breed types). Five percent of CE cases received grooming-related supplies to support pet caregivers' in-home grooming capabilities. Our findings underscore the need to understand the scope of grooming-related concerns among animals served by veterinarians and other community programs to improve animals' access to health-related services.
The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
Authors: Santamarina Aline Boveto , Moraes Ruan Carlos Macêdo , Nehmi Filho Victor , Murata Gilson Masahiro , de Freitas Jéssica Alves , de Miranda Danielle Araujo , Cerqueira Anderson Romério Azevedo , Costa Soraia Katia Pereira , Ferreira Ana Flávia Fernandes , Britto Luiz Roberto , de Camargo Juliana Alves , Rodrigues de Oliveira Daniela , de Jesus Flavia Neto , Otoch José Pinhata , Pessoa Ana Flávia Marçal
Published: February 2022

The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-β, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPARγ coactivator 1 α (Pgc-1α), interleukin-6 (Il-6), and interleukin-10 (Il-10) gene expression were augmented, while hepatic steatosis decreased and liver parenchyma was recovered. The glutathione-S-transferase activity status was found to be modulated by the supplement. We discovered that the new nutraceutical was able to improve insulin resistance and hepatic steatosis mainly by regulating IL-6, IL-10, and Pgc-1α gene expression.
The Non-Specific Drp1 Inhibitor Mdivi-1 Has Modest Biochemical Antioxidant Activity
Authors: Bordt Evan A. , Zhang Naibo , Waddell Jaylyn , Polster Brian M.
Published: February 2022

Mitochondrial division inhibitor-1 (mdivi-1), a non-specific inhibitor of Drp1-dependent mitochondrial fission, is neuroprotective in numerous preclinical disease models. These include rodent models of Alzheimer’s disease and ischemic or traumatic brain injury. Among its Drp1-independent actions, the compound was found to suppress mitochondrial Complex I-dependent respiration but with less resultant mitochondrial reactive oxygen species (ROS) emission compared with the classical Complex I inhibitor rotenone. We employed two different methods of quantifying Trolox-equivalent antioxidant capacity (TEAC) to test the prediction that mdivi-1 can directly scavenge free radicals. Mdivi-1 exhibited moderate antioxidant activity in the 2,2′-azinobis (3-ethylbenzothiazoline 6-sulfonate) (ABTS) assay. Half-maximal ABTS radical depletion was observed at ~25 μM mdivi-1, equivalent to that achieved by ~12.5 μM Trolox. Mdivi-1 also showed antioxidant activity in the α, α-diphenyl-β-picrylhydrazyl (DPPH) assay. However, mdivi-1 exhibited a reduced capacity to deplete the DPPH radical, which has a more sterically hindered radical site compared with ABTS, with 25 μM mdivi-1 displaying only 0.8 μM Trolox equivalency. Both assays indicate that mdivi-1 possesses biochemical antioxidant activity but with modest potency relative to the vitamin E analog Trolox. Future studies are needed to evaluate whether the ability of mdivi-1 to directly scavenge free radicals contributes to its mechanisms of neuroprotection.
Are the Currently Available Elastography Methods Useful in the Assessment of Chronic Kidney Disease? A Systematic Review and a Meta-Analysis
Authors: Maralescu Felix-Mihai , Chiodan Milena , Sircuta Alexandru , Schiller Adalbert , Petrica Ligia , Bob Flaviu
Published: February 2022

Background: We require an quantitative imaging technique for the diagnosis and assessment of chronic kidney disease (CKD). Renal elastography has been widely used in recent years in different studies; however, the results across them are not consistent and, as a result, we conducted a meta-analysis of the published literature on this topic. Methods: The databases of PubMed, Medscape, Medline were searched for all studies published in English from 2010 until November 2021 that evaluated kidney shear wave speed (SWS) by elastography in patients with CKD. Trial design, methodological information, patient characteristics, interventions, results, and outcome data were all collected from each study according to a set protocol. Results: We found 37 publications, yet only 18 studies that utilized point shear wave elastography (Virtual Touch Quantification—VTQ system) were compared because the values achieved using different types of elastography are not evaluable. Finally, 1995 attendees (1241 patients with CKD versus 781 healthy subjects as the control group) were included. When comparing mean values of kidney SWS between studies we found increased heterogeneity Q = 513.133; DF = 10; p < 0001, I2 (inconsistency) = 98.12% (95% CI for I2 97.52–98.57%). With a standardized mean difference of −0.216, patients with CKD have a lower kidney SWS than healthy controls. A positive association between kidney SWS and eGFR was also discovered across the presented studies, with a pooled correlation coefficient of 0.38 (Z = 10.3, p < 0.001), Q = 73.3, DF = 5, p < 000.1, I2 = 93.18% (95% CI for I2 87.86 to 96.18). The pooled area under the ROC curve for kidney SWS to predict chronic kidney disease was 0.831 (95% CI, p < 0.001), Q = 28.32, DF = 6, p = 0.0001, I2 = 78.8% (95% CI for I2 56.37 to 89.72). In the four articles that used the Elast-PQ method, the data presented were insufficient for statistical analysis: area under the curve (AUC) values are used to compare distinct characteristics (differentiating kidney SWS between mildly and moderately impaired kidneys, between non-diabetic/prediabetic/diabetic patients, or kidney SWS between the CKD and control group), therefore not being suitable for further evaluation. Conclusions: The results show that patients with CKD have a lower kidney SWS than healthy controls. However, the number of studies involving renal elastography that have been published is limited and show an increased heterogeneity. Further research is needed to determine which factors actually influence kidney SWS in CKD patients and, as a result, to specify the role and indication of renal elastography in clinical practice.
Least-Squares Reverse Time Migration in Imaging Domain Based on Global Space-Varying Deconvolution
Authors: Li Bo , Sun Minao , Xiang Chen , Bai Yingzhe
Published: February 2022

The classical least-squares migration (LSM) translates seismic imaging into a data-fitting optimization problem to obtain high-resolution images. However, the classical LSM is highly dependent on the precision of seismic wavelet and velocity models, and thus it suffers from an unstable convergence and excessive computational costs. In this paper, we propose a new LSM method in the imaging domain. It selects a spatial-varying point spread function to approximate the accurate Hessian operator and uses a high-dimensional spatial deconvolution algorithm to replace the common-used iterative inversion. To keep a balance between the inversion precision and the computational efficiency, this method is implemented based on the strategy of regional division, and the point spread function is computed using only one-time demigration/migration and inverted individually in each region. Numerical experiments reveal the differences in the spatial variation of point spread functions and highlight the importance to use a space-varying deconvolution algorithm. A 3D field case in Northwest China can demonstrate the effectiveness of this method on improving spatial resolution and providing better characterizations for small-scale fracture and cave units of carbonate reservoirs.
The Static and Dynamic Analyses of Drivers’ Gaze Movement Using VR Driving Simulator
Authors: Chung Jiyong , Lee Hyeokmin , Moon Hosang , Lee Eunghyuk
Published: February 2022

Drivers collect information of road and traffic conditions through a visual search while driving to avoid any potential hazards they perceive. Novice drivers with lack of driving experience may be involved in a car accident as they misjudge the information obtained by insufficient visual search with a narrower field of vision than experienced drivers do. In this regard, the current study compared and identified the gap between novice and experienced drivers in regard to the information they obtained in a visual search of gaze movement and visual attention. A combination of a static analysis, based on the dwell time, fixation duration, the number of fixations and stationary gaze entropy in visual search, and a dynamic analysis using gaze transition entropy was applied. The static analysis on gaze indicated that the group of novice drivers showed a longer dwell time on the traffic lights, pedestrians, and passing vehicles, and a longer fixation duration on the navigation system and the dashboard than the experienced ones. Also, the novice had their eyes fixed on the area of interests straight ahead more frequently while driving at an intersection. In addition, the novice group demonstrated less information at 2.60 bits out of the maximum stationary gaze entropy of 3.32 bits that a driver can exhibit, which indicated that their gaze fixations were concentrated. Meanwhile, the experienced group displayed approx. 3.09 bits, showing that their gaze was not narrowed on a certain area of interests, but was relatively evenly distributed. The dynamic analysis results showed that the novice group conducted the most gaze transitions between traffic lights, pedestrians and passing vehicles, whereas experienced drivers displayed the most transitions between the right- and left-side mirrors, passing vehicles, pedestrians, and traffic lights to find more out about the surrounding traffic conditions. In addition, the experienced group (3.04 bits) showed a higher gaze transition entropy than the novice group (2.21 bits). This indicated that a larger entropy was required to understand the visual search data because visual search strategies changed depending on the situations.
HSVNet: Reconstructing HDR Image from a Single Exposure LDR Image with CNN
Authors: Lee Min Jung , Rhee Chi-hyoung , Lee Chang Ha
Published: February 2022

Most photographs are low dynamic range (LDR) images that might not perfectly describe the scene as perceived by humans due to the difference in dynamic ranges between photography and natural scenes. High dynamic range (HDR) images have been used widely to depict the natural scene as accurately as possible. Even though HDR images can be generated by an exposure bracketing method or HDR-supported cameras, most photos are still taken as LDR due to annoyance. In this paper, we propose a method that can produce an HDR image from a single arbitrary exposure LDR image. The proposed method, HSVNet, is a deep learning architecture using a Convolutional Neural Networks (CNN) based U-net. Our model uses the HSV color space that enables the network to identify saturated regions and adaptively focus on crucial components. We generated a paired LDR-HDR image dataset of diverse scenes including under/oversaturated regions for training and testing. We also show the effectiveness of our method through experiments, compared to existing methods.
Circular RNA ITCH: An Emerging Multifunctional Regulator
Authors: Su Kaixin , Yi Qiao , Dai Xiaohan , Liu Ousheng
Published: February 2022

In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target.
Corpuscular Fragility and Metabolic Aspects of Freshly Drawn Beta-Thalassemia Minor RBCs Impact Their Physiology and Performance Post Transfusion: A Triangular Correlation Analysis In Vitro and In Vivo
Authors: Anastasiadi Alkmini T. , Arvaniti Vasiliki-Zoi , Paronis Efthymios C. , Kostomitsopoulos Nikolaos G. , Stamoulis Konstantinos , Papassideri Issidora S. , D’Alessandro Angelo , Kriebardis Anastasios G. , Tzounakas Vassilis L. , Antonelou Marianna H.
Published: February 2022

The clarification of donor variation effects upon red blood cell (RBC) storage lesion and transfusion efficacy may open new ways for donor–recipient matching optimization. We hereby propose a “triangular” strategy for studying the links comprising the transfusion chain—donor, blood product, recipient—as exemplified in two cohorts of control and beta-thalassemia minor (βThal+) donors (n = 18 each). It was unraveled that RBC osmotic fragility and caspase-like proteasomal activity can link both donor cohorts to post-storage states. In the case of heterozygotes, the geometry, size and intrinsic low RBC fragility might be lying behind their higher post-storage resistance to lysis and recovery in mice. Moreover, energy-related molecules (e.g., phosphocreatine) and purine metabolism factors (IMP, hypoxanthine) were specifically linked to lower post-storage hemolysis and phosphatidylserine exposure. The latter was also ameliorated by antioxidants, such as urate. Finally, higher proteasomal conservation across the transfusion chain was observed in heterozygotes compared to control donors. The proposed “triangularity model” can be (a) expanded to additional donor/recipient backgrounds, (b) enriched by big data, especially in the post-transfusion state and (c) fuel targeted experiments in order to discover new quality biomarkers and design more personalized transfusion medicine schemes.