bluuebunny/crossref_metadata_2025 huggingface dataset:
Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster
Authors: Lyu Yang , Promislow Daniel E. L. , Pletcher Scott D.
Published: June 2021

Aging arises from complex interactions among multiple biochemical products. Systems-level analyses of biological networks may provide insights into the causes and consequences of aging that evade single-gene studies. We have previously found that dietary choice is sufficient to modulate aging in the vinegar fly,Drosophila melanogaster. Here we show that nutrient choice influenced several measures of metabolic network integrity, including connectivity, community structure, and robustness. Importantly, these effects are mediated by serotonin signaling, as a mutation in serotonin receptor 2A (5-HT2A) eliminated the effects of nutrient choice. Changes in network structure were associated with organism resilience and increased susceptibility to genetic perturbation. Our data suggest that the behavioral or perceptual consequences of exposure to individual macronutrients, involving serotonin signaling through 5-HT2A, qualitatively change the state of metabolic networks throughout the organism from one that is highly connected and robust to one that is fragmented, fragile, and vulnerable to perturbations.
General theory and observation of Cherenkov radiation induced by multimode solitons
Authors: Eftekhar M. A. , Lopez-Aviles H. , Wise F. W. , Amezcua-Correa R. , Christodoulides D. N.
Published: June 2021

Advancements in computational capabilities along with the possibility of accessing high power levels have stimulated a reconsideration of multimode fibers. Multimode fibers are nowadays intensely pursued in terms of addressing longstanding issues related to information bandwidth and implementing new classes of high-power laser sources. In addition, the multifaceted nature of this platform, arising from the complexity associated with hundreds and thousands of interacting modes, has provided a fertile ground for observing novel physical effects. However, this same complexity has introduced a formidable challenge in understanding these newly emerging physical phenomena. Here, we provide a comprehensive theory capable of explaining the distinct Cherenkov radiation lines produced during multimode soliton fission events taking place in nonlinear multimode optical fibers. Our analysis reveals that this broadband dispersive wave emission is a direct byproduct of the nonlinear merging of the constituent modes comprising the resulting multimode soliton entities, and is possible in both the normal and anomalous dispersive regions. These theoretical predictions are experimentally and numerically corroborated in both parabolic and step-index multimode silica waveguides. Effects arising from different soliton modal compositions can also be accounted for, using this model. At a more fundamental level, our results are expected to further facilitate our understanding of the underlying physics associated with these complex “many-body” nonlinear processes.
Japanese carbon emissions patterns shifted following the 2008 financial crisis and the 2011 Tohoku earthquake
Authors: Long Yin , Yoshida Yoshikuni , Liu Qiaoling , Guan Dabo , Zheng Heran , Li Yuan , Gasparatos Alexandros
Published: June 2021

Unexpected events such as economic crises and natural disasters can have profound implications for energy systems and climate change mitigation efforts at different levels. Here we explore the national and regional carbon emission patterns (and their drivers) for the main economic sectors in Japan between 2007 and 2015, a period shaped by the 2008 financial crisis and the 2011 Tohoku Earthquake. Following the 2011 earthquake the previously decreasing regional emissions patterns started increasing in practically all regions except Hokkaido. This was mainly due to growing coal use particularly in the Kyushu, Chugoku and Kansai regions. Furthermore, most regions experienced shifts in the dominance of different drivers of emissions over time, with a stronger initial impact from economic effects after the 2008 financial crisis, followed by energy structure after the 2011 earthquake, and then by economic effects and energy intensity. These results offer a more nuanced understanding of how individual events can affect emissions at different periods and levels (national vs. regional) to inform the design of climate change mitigation strategies.
Giant photoluminescence enhancement in MoSe2 monolayers treated with oleic acid ligands
Authors: Tanoh Arelo O. A. , Alexander-Webber Jack , Fan Ye , Gauriot Nicholas , Xiao James , Pandya Raj , Li Zhaojun , Hofmann Stephan , Rao Akshay
Published: June 2021

Following our previous work on WS2 surface treatment with oleic acid (OA), we show that OA also greatly improves the optoelectronic characteristics of MoSe2. Optical and electronic measurements point to selenide vacancy passivation by OA ligands.
Correction: Determining the geographical origin of milk by multivariate analysis based on stable isotope ratios, elements and fatty acids
Authors: Xu Siyan , Zhao Chaomin , Deng Xiaojun , Zhang Runhe , Qu Li , Wang Min , Ren Shuo , Wu Hao , Yue Zhenfeng , Niu Bing
Published: June 2021

Correction for ‘Determining the geographical origin of milk by multivariate analysis based on stable isotope ratios, elements and fatty acids’ by Siyan Xu et al., Anal. Methods, 2021, DOI: 10.1039/d1ay00339a.
Energy storage electrochromic devices in the era of intelligent automation
Authors: Lu Zelin , Zhong Xiaolan , Liu Xueqing , Wang Jinliang , Diao Xungang
Published: June 2021

A catalog summary and capacity comparison of ECESDs.
Production of plant volatile terpenoids (rose oil) by yeast cell factories
Authors: Li Rongsheng , Wang Kou , Wang Dong , Xu Liping , Shi Yusong , Dai Zhubo , Zhang Xueli
Published: June 2021

A synthetic biology platform for the production of plant volatile terpenoids (rose oil) was established, which provides a promising approach for a sustainable source of important plant natural products.
Analyzing protein–protein interactions in rare cells using microbead-based single-molecule pulldown assay
Authors: Zhao Qirui , Shen Yusheng , Li Xiaofen , Tian Fang , Yu Xiaojie , Yobas Levent , Park Hyokeun , Duan Yuanyuan , Huang Pingbo
Published: June 2021

Protein complexes were captured by antibody modified agarose microbeads and detected by corresponding fluorophore-labeled antibodies. This assay is simple and highly sensitive for studying protein–protein interactions in rare cells.
Gas-sensing performance of BC3 nanotubes for detecting poisonous cyanogen gas: a periodic DFT approach
Authors: Rahimi Rezvan , Solimannejad Mohammad
Published: June 2021

An efficient sensor was produced to detect toxic cyanogen gas even in the presence of water, oxygen, and nitrogen molecules due to the significant sensitivity and selectivity of the desired BC3NTs.
Correction: Mononuclear copper(i) complexes of triphenylphosphine and N,N′-disubstituted thioureas as potential DNA binding chemotherapeutics
Authors: Khan Syed Ishtiaq , Ahmad Sajjad , Khan Inayat Ali , Badshah Amin , Rauf Muhammad Khawar , Patujo Jahangeer , Siddiq Muhammad Nasir , Kausar Samia , Altaf Ataf Ali
Published: June 2021

Correction for ‘Mononuclear copper(i) complexes of triphenylphosphine and N,N′-disubstituted thioureas as potential DNA binding chemotherapeutics’ by Syed Ishtiaq Khan et al., New J. Chem., 2021, 45, 8925–8935, DOI: 10.1039/D0NJ06182D.
Correction: Synthesis of heteroleptic phosphine–copper(i) complexes: fluorescence sensing and catalytic properties
Authors: Luo Chen-Lin , Hu Chu-Xing , Shang Ping , Wen Guan-Zhao , Zhu Jia-Jun , Xuan Ya-Hui , Xia Bang-Lian , Liu Yu-Chen , Jiang Zi-Hao , Dong Geng , Zhang Wei , Gui Liu-Cheng , Jiang Xuan-Feng
Published: June 2021

Correction for ‘Synthesis of heteroleptic phosphine–copper(i) complexes: fluorescence sensing and catalytic properties’ by Chen-Lin Luo et al., New J. Chem., 2021, 45, 8910–8917, DOI: 10.1039/D0NJ06095J.
Transforming electron-rich hetero-buckybowls into electron-deficient polycycles
Authors: Liu Zhe , Song Wenru , Yan Chaoxian , Liu Zitong , Zhang Hao-Li , Shao Xiangfeng
Published: June 2021

Oxidation of trichalcogenasumanenes (TCSs) with NO species results in the simultaneous formation of ortho-quinone and diester groups. This reaction enables the transformation of electron-rich TCSs into electron-deficient polycycles.
Palladium-catalyzed selective defluorinative arylation for the efficient stereospecific synthesis of (E)-β-fluoroacrylamides
Authors: He Shi-Yu , Yan Xiao-Wei , Tu Hai-Yong , Zhang Xing-Guo
Published: June 2021

A practical and efficient method for the synthesis of (E)-β-fluoroacrylamides was developed by the selective defluorinative arylation of trifluoropropanamides with arylboronic acids.
Hetero-oligomerization of Bacillus thuringiensis Cry1A proteins enhance binding to the ABCC2 transporter of Spodoptera exigua
Authors: Pinos Daniel , Joya Noelia , Herrero Salvador , Ferré Juan , Hernández-Martínez Patricia
Published: June 2021

The ATP binding cassette (ABC) transporters are membrane proteins that can act as putative receptors for Cry proteins from Bacillus thuringiensis (Bt) in the midgut of different insects. For the beet armyworm, Spodoptera exigua, ABCC2 and ABCC3 have been found to interact with Cry1A proteins, the main insecticidal proteins used in Bt crops, as well as Bt-based pesticides. The ABCC2 has shown to have specific binding towards Cry1Ac and is involved in the toxic process of Cry1A proteins, but the role of this transporter and how it relates with the Cry1A proteins is still unknown. Here, we have characterized the interactions between the SeABCC2 and the main proteins that bind to the receptor. By labeling the Cry1Aa protein, we have found that virtually all of the binding is in an oligomeric state, a conformation that allowed higher levels of specific binding that could not be achieved by the monomeric protein on its own. Furthermore, we have observed that Cry1A proteins can hetero-oligomerize in the presence of the transporter, which is reflected in an increase in binding and toxicity to SeABCC2-expressing cells. This synergism can be one of the reasons why B. thuringiensis co-expresses different Cry1 proteins that can apparently have similar binding preferences. The results from in vitro competition and ex vivo competition showed that Cry1Aa, Cry1Ab and Cry1Ac share functional binding sites. By using Cry1Ab–Cry1Ac chimeras, the presence of domain I from Cry1A proteins was revealed to be critical for oligomer formation.
A Ka‐band tunable LNA for MB‐OFDM application
Authors: Hosseini Seyed Alborz , Mohammad‐Taheri Mahmoud , Khosravi Ramin , Moradi Gholamreza
Published: June 2021

In this paper a novel tuneable LNA is presented. This LNA is designed with two separated structures which both of them utilize noise cancellation technique and some other approaches such as gain boosting and T‐transformer feedback. Each proposed LNA has two stages that the first stage is designed based on noise cancellation and the second stage uses common gate structure. The proposed LNA type (A) utilises the switched capacitance in the first stage to tune the centre frequency and a gain boosting in the second stage to increase the gain. The second proposed LNA type (B) has implemented the parallel networks to decrease the change in the gain values of the LNA in different channels. The T‐transformer approach is used in each parallel network to decrease the inductors value and improve the input matching. In the second stage, the negative feedback is also employed to control the bandwidth. The proposed LNA is simulated in ADS software with TSMC 130 nm CMOS technology and the layout is designed by Cadence. The LNA type (A) has 22.7 dB gain in 28.8 GHz and the noise figure of 2 dB. The IIP3 for this LNA is 0 dBm in 25.42 GHZ. For the LNA type (B), the gain and noise figure standard deviations are 0.25 and 0.057 respectively which shows minimum variations by frequency tuning. For this LNA, the maximum gain is 20.5 dB and the noise figure is 2 dB at 31.42 GHz. Finally the performances of the proposed LNAs have been compared with those of LNAs which have been recently published.
Research on drilling process technology and parameter optimization in soft coal seam
Authors: Wu Weizheng
Published: June 2021

Due to the low firmness coefficient of soft coal seam and the influence of formation pressure and in-situ stress, it is easy to cause hole collapse in bedding drilling, resulting in low hole forming rate and insufficient hole forming depth, so the drilling technology needs to be improved. This paper focuses on the study of hole forming technology and parameters of bedding drilling in soft coal seam. The research results show that: the key to improve the construction efficiency of bedding drilling in soft coal seam is to improve the slag removal ability of drilling engineering, and the drilling technology of spiral drilling and pressure air slag removal is conducive to improve the drilling depth and drilling effect. The hole forming process and parameters of spiral drilling and pressure air slag removal are systematically described. The drill pipe speed, the coal conveying capacity in the hole, the minimum wind speed of pressure air slag removal and the air supply pressure of slag removal are determined. It is of great practical significance to develop and improve the drilling technology of bedding hole drilling in soft coal seam to improve the gas drainage capacity of coal mine and the drilling depth and rate of bedding hole drilling in soft coal seam.
Diagnosis and Treatment of Unbalance about Power Plant Rotating Auxiliary Equipment
Authors: Shuai Zhang , Zhengfeng Wu , Changhao Wu
Published: June 2021

This paper introduces the characteristics of unbalanced fault and the handling method of rigid rotor unbalanced fault, and expounds the handling process of large fan unbalanced fault through two balancing cases, which can be used for reference to the fault analysis and handling of the unbalanced fault of power plant rotating auxiliary equipment.
Influence of Buoy Size on Accelerated Wave Power Generation Device
Authors: Chen Hu , Ji Zhifei , Hu Yusheng , Lin Min
Published: June 2021

This paper proposed a pulley-buoy accelerated wave energy linear power generation system, and the feasibility and effectiveness of this system were verified through experimental research. Compared with the traditional wave energy power generation system with three-stage energy conversion links, the pulley-buoy accelerated wave energy linear power generation system omits the intermediate energy transfer and conversion link, and realizes the direct gain of electric energy from the buoy movement caused by wave, and by introducing the pulley combination, the movement speed of the buoy is enlarged, the power generation of the linear power generation system is increased, thereby the wave energy conversion efficiency of the system is improved. Under laboratory conditions, a small-size pulley-buoy accelerated wave energy linear power generation system prototype and a swing-plate wave-making system were built to explore the effects of different buoy sizes on the power generation performance of the system. The test results show that within the research scope of this paper, increasing the size of the buoy can effectively increase the wave energy conversion efficiency of the system and improve the power generation performance of the accelerated wave energy power generation system. The research results in this paper provide useful experience for the practical application and efficient operation of wave energy power generation systems.
The evaluation of the thermal storage electric heating load adjustability
Authors: Jing Lu , Suxiu Li , Weizheng Kong
Published: June 2021

In recent years, in order to solve the environmental pollution problem caused by coal-fired heating in the heating area of north of china, electric heating has received extensive attention and has gradually been developed vigorously. Considering the building characteristics, outdoor temperature, indoor comfort and other factors, the building heat load adjustability model is established, and the heat storage device's load adjustability model considering the current operating status and heat storage capacity of the heat storage device is established, and the two are added together An evaluation model of the adjustability of regenerative electric heating users' load is obtained. This model not only considers the user comfort and the adjustment potential of the building where it is located, but also considers the adjustment potential of the heat storage device, which can more comprehensively and accurately evaluate the user load adjustment potential of thermal storage electric heating.
Research on Hand Action Pattern Recognition of Bionic Limb Based on Surface Electromyography
Authors: Yin Zihan
Published: June 2021

Hands are important parts of a human body. It is not only the main tool for people to engage in productive labor, but also an important communication tool. When the hand moves, the human body produces a kind of signal named surface electromyography (sEMG), which is a kind of electrophysiological signal that accompanies muscle activity. It contains a lot of information about human movement consciousness. The bionic limb is driven by multi-degree-freedom control, which is got by converting the recognition result and this can meet the urgent need of people with disabilities for autonomous operation. A profound study of hand action pattern technology based on sEMG signals can achieve the ability of the bionic limb to distinguish the hand action fast and accurately. From the perspective of the pattern recognition of the bionic limb, this paper discussed the human hand action pattern recognition technology of sEMG. By analyzing and summarizing the current development of human hand movement recognition, the author proposed a bionic limb schema based on artificial neural network and the improved DT-SVM hand action recognition system. According to the research results, it is necessary to expand the type and total amount of hand movements and gesture recognition, in order to adapt to the objective requirements of the diversity of hand action patterns in the application of the bionic limb.
Lifetime Prediction method of LED Light-emitting Device Based on Approximate Analysis
Authors: Wenting Cai , Sheng Li , Qinghui Meng , Haisong Huang
Published: June 2021

Compared with other light sources, LED light source has a longer service life and will not suddenly fail. Due to its high efficiency, energy saving and long life, LED has become the most popular light source at present. However, it is no longer considered to meet the application requirements, and the time that the light flux decays to this level is considered to be the life of the LED. This paper introduces the approximate method used to predict the lumen maintenance life of LED lamps. The experimental results obtained by the approximate method are compared with the TM-21 standard. Eventually, it is concluded that the approximate method provides more reliability information than the original TM-21 standard, and the obtained results are more reference, more accurate and more reliable.
Conductivity Variation during Irreversible Electroporation
Authors: Xu Chao , Yang Lei
Published: June 2021

Irreversible electroporation (IRE) is an emerging tumour ablation technique, which utilizes non thermoelectric pulse to ablate tumours. Compared with the common tumour treatment methods, e.g., surgery, chemotherapy and radiotherapy, IRE has advantages of short action time, no massive bleeding of tissue during ablation, avoiding heat sink effect, etc. However, the process of IRE will be affected by the distribution of E-field of the tissue. The major factors which affect E-field distribution are parameters of the electrical pulse and characteristics of the tissue, e.g., the conductivity of the tissue. We utilized the finite element analysis software COMSOL Multiphysics 5.4 to calculate the variation in liver tissue conductivity during IRE. In this study, there is a Low-Voltage High-Frequency (LVHF) pulse involves 3500 unipolar and bipolar pulses, and a High-Voltage Low-Frequency (HVLF) pulse involves eight unipolar and bipolar pulses. The results show that the conductivity change of the HVLF pulse is higher than that of the LVHF pulse due to the higher strength of E-field. The most important conclusion is that the LVHF pulse can only change the tissue conductivity near the electrode tip. The HVLF pulse will significantly change the conductivity in the tissue between the electrodes.
Mechanism and control strategy of ammonia and nitrous oxide during composting of municipal solid wastes
Authors: Yi-Xiao Chen , Yi-Ming Lu , Jin-Tao Mo , Jia-Jing Pan , Jun Zhang
Published: June 2021

Aerobic composting is an effective way to realize recycling of organic solid wastes. It is not only convenient for operation and management, but also can convert waste into organic fertilizer. However during the composting process, the nitrogen in the heap exists in the form of organic nitrogen, ammonium nitrogen, nitrate nitrogen and other forms and is transformed into each other. It is also a potential source of ammonia (NH3) and nitrous oxide (N2O), and it is closely related to the environmental problems such as haze pollution and greenhouse effect. Combining with the researches of domestic and foreign scholars, this paper summarizes the form transformation of nitrogen elements, the emission mechanism of NH3 and N2O, and the adjustment and control measures in the aerobic composting process of the organic solid wastes, and it prospects the research direction for aerobic composting of the organic solid wastes.
A method for determining unsaturated strength parameters in stability analysis of loess slope
Authors: Xi Yu , Guo Chao , Li JIachen , Zhang Yao , Yang Shasha
Published: June 2021

In recent years, with the rapid development of social economy and progress of human activities in loess area, the Loess Plateau become one of the areas with the most serious soil erosion and the most frequent occurrence of geological disasters in the world. Landslide, collapse, debris flow and ground subsidence are common geological disasters in the Loess Plateau, resulting in a more fragile ecological environment. Therefore, it is very important to accurately predict the stability of loess slope for engineering safety and ecological protection in loess region. But loess is a typical unsaturated soil. the formula of unsaturated strength is seldom used in practical applications. The reason is that the matric suction is difficult to measure. And it cannot be applied in engineering practice. In this paper, based on unsaturated soil shear strength formula of Fredlund, the direct shear test under different moisture content is conducted with the samples of Q1 loess. The effective cohesion and the effective internal friction angle are obtained. Through the matric suction test, the soil-water characteristic curve is plotted. Combined cohesion and matric suction, the strength parameters of unsaturated loess in formula of Fredlund can be informed.
Design of On-line Water Quality Monitoring System
Authors: Fenfang Tan
Published: June 2021

Water is the source of human life. However, a large amount of domestic sewage, industrial wastewater and agricultural wastewater produced in human production and life pollute the surface water, threatening normal production and life of people.In order to grasp the water quality fully, the temperature, PH. turbidity and conductivity sensors are adopted to collect various water quality parameters, and necessary software and hardware design of the on-line water quality' monitoring system is completed to provide a basis for subsequent water quality monitoring in various industries.
The Impacts of Social Security Expenditure on Rural Residents' Medical Consumption in Hubei Province
Authors: Mengyu Yan , Xi Yang
Published: June 2021

This paper analyzes the effect ofSocial Security Expenditure issued by Hubei Province on health services for the peasantry, and provides the evidences towards the integration process regarding medical insurances of the urban and the countryside.Based on the related economical data collected from countrysides area of Hubei province from 2003-2019, this paper utilizes the outcome of Cointegration and Granger Casual Relation Test to prove the relation from social security and employment fiscal expenditures and rural households’ annual per capita net income.Then the research adds the control variables to perform the examination on robustness. The study shows that the social security expenditure has a significant impact on rural residents' medical consumption.Considering that medical insurance is an important part of social security,we should ensure the steadiness of the further improvement achieved by system of health insurance,increase government financial investment and strengthen the construction of rural basic health and medical facilities.Hubei Province should improve the level of rural medical and health security, strengthen management, improve efficiency and improve mechanisms, and deepen the reform of the medical and health system.Therefore, the economical burden of rural residents brought by seeking medical treatment will be reduced in order to narrow the difference between the urban and the countryside which will further promote the equality in medical system.
A Case of Amyloidosis Cutis Dyschromica
Authors: Hongzhi Gu , Lian Zhang , Yan Xiao
Published: June 2021

The patient was a 56-year-old female. The whole body has brown patches for 16 years. Dermatological examination: brown patches were observed on the trunk and lower limbs, with scattered hypomigmentation patches and symmetrical distribution of skin lesions. Histopathology of the skin showed mild hyperkeratosis in the epidermis, focal liquefaction degeneration in the basal layer, masses of light red stained material in the dermal papilla, scattered or small patches of lymphocytes and tissue cell infiltration around capillaries in the superficial dermis, more pigmentophagocytes and positive methyl violet staining were observed. Diagnosis: cutaneous amyloidosis with abnormal pigmentation. The patient is still being followed up.
Snapshot of Schizophrenia: Current Knowledge and Prospects
Authors: Gao Ruixue
Published: June 2021

Schizophrenia is a widely known mental disorder that can cause severe life struggles if not being treated properly. According to its diagnose, patients suffer from delusions, hallucinations, and other disorders. For treatment, antipsychotics are commonly used, but their efficiency cannot be promised due to the lack of knowledge about this illness. In previous studies, scientists had suggested neuronal, genetic, epigenetic, and immunological factors. However, to fully understand the mechanism of schizophrenia, there is still a long way to go for understanding how these factors interact and induce dysfunction.
Therapeutic Effect of Yiqi Tongnao Decoction on Acute Cerebral Infarction of Qi Deficiency and Blood Stasis Type
Authors: Guo Jian , Ren Deqi , Chang Xuehui
Published: June 2021

The object is to explore the clinical effect of applying Yiqi Tongnao Decoction in the treatment of patients with acute cerebral infarction of Qi deficiency and blood stasis. In this study, patients in our hospital were taken as the main research objects, all of whom were patients with acute cerebral infarction of Qi deficiency and blood stasis type. The number of patients is 100. The study period is from January 2020 to January 2021. The 100 patients selected for this study are divided into two groups. One group is given conventional western medicine treatment as the control group, and the other group is given Yiqi Tongnao Decoction treatment as the experimental group, the therapeutic effects of the two groups of patients were compared and analyzed. The scores of various TCM syndromes of the experimental group were lower than those of the control group, and the scores of neurological deficit and blood viscosity after treatment were lower than those of the control group. The effective rate of treatment was 94.00%, which was higher than 78.00% of the control group. The adverse reaction rate of patients in the group was 6.00%, which was lower than that in the control group, and the differences in the data were statistically significant (P<0.05). The application of Yiqi Tongnao Decoction in patients with acute cerebral infarction of Qi deficiency and blood stasis type has significant clinical effects. It can improve the clinical symptoms of patients, reduce the incidence of adverse reactions, and has a positive significance in promoting the recovery of patients.
Analysis of the Association of Professional Sports with Athletes’ Cranial Nerve Dysfunction and Mental Health Problems
Authors: Yang Hanyun
Published: June 2021

This article discusses the association of professional sports with athletes’ cranial nerve dysfunction and mental health problems by conducting a literature review of the latest researches and theories. Professional or elite athletes, especially those in collision, combat and contact sports, are very likely to get multiple concussions or repeated traumatic brain injuries, which are often associated with cranial nerve dysfunction and chronic traumatic encephalopathy, resulting in various neurological impairments and diseases as well as mental health problems (e.g. depression and anxiety). In addition, other factors can also cause psychological problems among professional athletes, such as pre-competition stress and adverse life events. In order to improve the physical and mental health of professional or elite athletes, there should be more policies and measures to promote the early identification, treatment and prevention of psychopathology and other sequelae of brain trauma. Besides, a proper mechanism and system should be set up to enable those athletes to get aware of and seek suitable assistance when these dysfunctions and disorders occur.
Polio in Afghanistan: a systemic review on eradication interventions and challenges
Authors: Lin Yitong
Published: June 2021

After the Global Polio Eradication Initiative was established, the global incidence of polio decreased by 99 percent. However, from a global perspective, the number of polio cases in Afghanistan is still increasing, therefore more attention should be brought to the issue of polio eradication in Afghanistan. This article is set out to revisit and analyze the interventions and challenges of polio eradication in Afghanistan. Data in the article are obtained from various academic journals and official public health websites. After reviewing the research results of public health experts throughout the years, it is evident that despite using multiple intervention measures in the eradication process, more effort is needed to address the challenges that are specific to different areas of Afghanistan. In the recent future, more cases of polio are expected due to the COVID-19 pandemic. Therefore, public health workers must increase the intensity of polio surveillance in Afghanistan and ensure that there are sufficient vaccines in stock when house-to-house vaccination begins again.
Screening for hub genes and signaling pathways of CD8+ T cells in systemic lupus erythematosus using bioinformatics
Authors: Wu Yuefeng
Published: June 2021

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, which can damage multiple organs. The adaptive immune system, including CD8+ T cells, plays an essential role in this disease. However, the pathogenesis of SLE remains unclear, and there is a lack of effective diagnosis and treatment methods for SLE. In particular, there has been little research on SLE biomarkers, which have been widely studied and used in cancer diagnosis and treatment. In this study, bioinformatics tools were used to screen for hub genes and signaling pathways involving CD8+ T cells in patients with SLE. This is the first determination of metabolic abnormalities in SLE CD8+ T cells using bioinformatics pathway enrichment analysis. The PPI network and MCC algorithm identified SKP2 as a potential biomarker for SLE.
Factors of Cell Degeneration or Death caused by Mutant Tau Protein
Authors: Mikiko O
Published: June 2021

Tau protein is a microtubule associated protein mainly expressed in neurons. Under pathological conditions, Tau protein is abnormally hyperphosphorylated and separated from microtubules. Abnormal Tau aggregates form nerve fiber tangles, which are insoluble aggregates in the brain. It is due to the microtubule rupture caused by Tau protein dysfunction and it is associated with neurofibrillar degeneration in Alzheimer's disease.This paper studies several reports and research on the structure and function of Tau protein, the role of Tau protein in pathological diseases and its relationship with neurodegenerative diseases. This paper concludes that Tau protein has undergone abnormal modification and aggregation in many neurodegenerative diseases, but the specific type of Tau protein that causes neurotoxicity, as well as the pathogenesis of its phosphorylation and functional injury inducing nerve apoptosis, are still not fully understood. Various abnormal modifications of Tau protein occur under pathological conditions, and fatal cascade events occur at different stages of neuron apoptosis. Therefore, the causes and effects of cytotoxicity mediated by Tau protein are very complicated. Different or even opposite conclusions are sometimes drawn in Tau protein-mediated neurodegeneration studies. This may be due to differences in Tau protein type, gene mutation and protein expression level.
Effects of intraocular pressure and aspheric transition zone ablation profile on corneal biomechanics after conventional refractive surgery
Authors: Du Ruirui , Fang Lihua , Song Yinyu , Tao Xingming , Lin Luchao
Published: June 2021

Our Purpose is to study the effects of intraocular pressure (IOP) and aspheric transition zone (ATZ) on corneal biomechanics after pure hyperopia correction by using the finite element analysis (FEA). The values of IOP were changed, and 1-5# aspheric transition zones were designed in 1-5D hyperopia correction model. Simulate and calculate the wavefront aberration, stress and vertex displacement of cornea. The results show that with the increase of IOP and diopter, defocus increases positively and sphere increases negatively. Diopter and IOP have slight influence on coma. At 22mmHg, the maximum value of defocus was 1.367mm at 5D-1#, and the maximum value of sphere was -0.32mm at 5D-5#. IOP and diopter have great influence on the stress in the marginal region of the anterior corneal surface, and 1D-1 # has the maximum value at 22mmHg. With the increase of IOP and diopter, the vertex displacement of posterior corneal surface increased. The ATZ ablation profile has little effects on the wavefront aberration and displacement. We can draw a conclusion that refractive surgery destroys the physiological structure of cornea and has a great influence on the biomechanical properties of cornea. IOP plays an important role in maintaining the physiological structure of cornea.
Drug Resistance of Ocular Bacteria Considering Biofilm Mechanism
Authors: Liu Yutong , Xu Xuanrong
Published: June 2021

In order to further analyze the relationship between the coating mechanism of microorganisms and their drug resistance, a study of ocular bacterial drug resistance considering the coating mechanism of microorganisms was proposed. Firstly, the mechanism of drug resistance was analyzed, and on this basis, the experimental study was carried out. Staphylococcus aureus DH5 with RP4 was used as the control α( R) Objective to investigate the relationship between drug-resistant bacteria and coating mechanism in the cross genus conjugation system of Pseudomonas aeruginosa PAOi and donor bacteria. The conclusion is that: under the condition that the horizontal transfer of drug-resistant genes between transgeneric bacteria in biofilm is inhibited, the frequency of drug-resistant gene conjugation and transfer gradually decreases, and the inhibition of the formation of drug-resistant bacterial biofilm will directly lead to the decrease of bacterial drug resistance.
Exploring the Relationship between Gut Microbiota and Major Depressive Disorders
Authors: Tian Catherine
Published: June 2021

Major Depressive Disorder (MDD) is a psychiatric disorder accompanied with a high rate of suicide, morbidity and mortality. With the symptom of an increasing or decreasing appetite, there is a possibility that MDD may have certain connections with gut microbiota, the colonies of microbes which reside in the human digestive system. In recent years, more and more studies started to demonstrate the links between MDD and gut microbiota from animal disease models and human metabolism studies. However, this relationship is still largely understudied, but it is very innovative since functional dissection of this relationship would furnish a new train of thought for more effective treatment of MDD. In this study, by using multiple genetic analytic tools including Allen Brain Atlas, genetic function analytical tools, and MicrobiomeAnalyst, I explored the genes that shows both expression in the brain and the digestive system to affirm that there is a connection between gut microbiota and the MDD. My approach finally identified 7 MDD genes likely to be associated with gut microbiota, implicating 3 molecular pathways: (1) Wnt Signaling, (2) citric acid cycle in the aerobic respiration, and (3) extracellular exosome signaling. These findings may shed light on new directions to understand the mechanism of MDD, potentially facilitating the development of probiotics for better psychiatric disorder treatment.
Rapid antimicrobial susceptibility testing from positive blood cultures based on Stimulated Raman Scattering Imaging analysis
Authors: Sun Bo , Hong Weili , Wang Pu , kang xixiong
Published: June 2021

The existing identification (ID) and antimicrobial susceptibility testing (AST) method requires at least two to three days to detect blood infection, and a fast and accurate detection method is very necessary for sepsis patients or Intensive Care Unit (ICU) patients. Here, we describe a direct isolated bacteria from a positive blood culture bottle (PBCB), and rapid AST method by femtosecond stimulated Raman scattering (SRS) imaging of deuterium oxide (D2O) metabolism, which can determine the antimicrobial susceptibility of bacteria from PBCB in 5-6 hours. The positive blood culture sample is passed through a filter membrane and mixed with cell lysis, after through the centrifugal which can directly isolated bacterium in order to identification by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS), following by antibiotic susceptibility testing by SRS imaging within a day. Overall, this rapid and rapid process combination of MALDI-TOF MS and SRS imaging of deuterium oxide (D2O) metabolism can solve the direct identification and antibiotic susceptibility testing of pathogen in positive blood cultures.
The diagnostic value of four-dimensional ultrasound examination of perineum in the diagnosis of postpartum pelvic floor dysfunction
Authors: Wu Wenfang , Li MeiYuan , Wu Kanghong , Xu Yiyun , Cai Yan
Published: June 2021

Objective to explore the diagnostic value of perineal four-dimensional ultrasound (4D-US) in postpartum pelvic floor dysfunction (PFD) disease. 328 postpartum PFD patients diagnosed by clinical pelvic floor palpation from June 2018 to December 2020 were selected as the PFD group, and 328 patients without PFD were selected as the control group. All participants underwent perineal 4D-US, the indicators were statistically analyzed. The results showed that the LAT of left and right, LHLR, LHAP, LHA, resting state and holding the breath in the PFD group were higher than those in the control group, and the difference was statistically significant (P<0.05). From cervix to lower margin of pubic symphysis, bladder to lower margin of pubic symphysis of the pubic symphysis, and from the ampulla of the rectum to the lower margin of the pubic symphysis, the PFD group was larger than the control group, but the result of urethral rotation was reversed, and the difference was statistically significant (P<0.05). The morphologic features of the levator ani muscle and pelvic fissure can be detected early using 4D-US, which is a reliable technique that can be learned in a short period of time.
The evaluation of proliferation ability of cardiomyocytes in heart failure
Authors: Gao Mengzi
Published: June 2021

The proliferation ability of cardiomyocytes is always under a controversial situation, especially under some stress condition such as heart failure disease and external damages. Heat failure (HF) is a complex clinical syndrome that results from left ventricular myocardial dysfunction and contributes to dyspnea, fatigue and fluid retention. The proliferation ability is related to the cell cycles and lot of cell-cycle related genes are involved in the evaluation of proliferation ability of cardiomyocytes. RNA-seq is a quite common technique in evaluate the transcription expression pattern of genes in many studies. Here in our article we analyzed the existing RNA-seq dataset to evaluate the mRNA expression level of several genes which can be indicators of the activity of cell cycles. We found that the cyclin D2 which is a cell cycle activator is upregulated in dilated cardiomyopathy (DCM) disease, indicating that the proliferation ability may be higher in DCM heart. The results throw light on the proliferation research of adult cardiomyocytes.
Exploration of Academic Postgraduate Medical Training System in the Context of "Internet plus"
Authors: Huang Xiaoshan , Yin Longwu , Zhou Bilan , Liu Zhifang , Bao Meihua
Published: June 2021

Higher education in China has entered a new era of global quality improvement and innovation. The cultivation of innovative talents is crucial for the development of our higher education. Within the framework of "Internet plus", the culture of university medical graduates must deeply integrate information technology. In the present study, an "Internet plus" academic medical postgraduate training system was discussed. This system includes the establishment of the curriculum system, innovation capability training system and quality evaluation system. By making full use of modern informatics technology, the “Internet plus” system improved the the innovation capability and quality of postgraduates significantly.
Analysis of Oxoglaucine in the Treatment of Breast Cancer Based on Network Pharmacology and Bioinformatics
Authors: Chen Ting , Chen Haiyu , Zhang Liang , Zhou Bin , Yang Chao , Huang Xulong , Huang Bin
Published: June 2021

To explore the potential molecular mechanism of Oxoglaucine(OG) in the treatment of Breast Cancer(BC) based on network pharmacology and bioinformatics. TCMSP and SwissTargetPrediction databases search for OG Related targets, and GeneCards database finds all BC-related targets. Take the intersection of OG and BC as all potential targets that inhibit BC. All potential targets are topologically analyzed by Cytoscape 3.7.1 software, and finally the core target is obtained. The start analysisi function in the DAVID database performs bioinformatics analysis on all core targets, and further visualizes them with the help of R language tools. As a result, 104 potential targets were obtained, of which SRC, PIK3CA, EGFR, MTOR, ESR1, MAPK1, PTGS2, AR, and NOS3 were the main core targets. OG inhibits the occurrence of BC through Pathways in cancer, PI3K-Akt signaling pathway, Proteoglycans in cancer, ErbB signaling pathway, HIF-1 signaling pathway related pathways, mainly involving signal transduction, protein phosphorylation, negative regulation of apoptotic process, positive regulation of transcription from RNA polymerase II promoter, phosphatidylinositol-mediated signaling biological processes. This study initially reveals the molecular mechanism of OG inhibiting BC, which provides a reference for further research.
Experimental study on thiosulfate leaching of gold from a high copper gold concentrate
Authors: Yanbo Chen , Guanglin Qin , Guangsheng Li , Xingfu Zhu , Congquan Yu , Zhongbo Lu , Qiang Ji , Juntong Zhang , Chao Xu , Mingming Cai , Tengyue Gao
Published: June 2021

The conventional cyanide leaching process is used to extract gold from a high copper gold concentrate. Because the copper associated minerals consume sodium cyanide in large quantities, the cost of the reagents is high and the economic benefit is not ideal. At the same time, a large number of cyanide tail slag are produced, which brings a series of environmental problems. In order to solve the environmental problems caused by excessive sodium cyanide consumption and cyanogen slag, the feasibility of leaching gold by thiosulfate in copper ammonia system was studied. The gold leaching rate of thiosulfate was increased to more than 90% by using the direct thiosulfate leaching process and pretreatment thiosulfate leaching process, which was close to the gold leaching index of sodium cyanide at the production site.
Fast Evaluation Model of Surfactant Flooding Based on Modification Fractional Flow Theory
Authors: Cui Ye
Published: June 2021

At present, the numerical simulation of surfactant flooding is implemented by commercial software, which requires a lot of input data, resulting in slow calculation speed and heavy workload. So it was not suitable for surfactant flooding revovery evaluation in a large number of oilfields. This paper presents a fast evaluation model of surfactant flooding based on modification fractional flow theory. Viral expansion, interfacial tension calculation formula, and the relative permeability correction model are introduced to simulate the surfactant displacement mechanism. The simulation model is applied in a low permeability reservoir, and the simulation results are compared with the eclipse software results. Their results are similar, which show that this model presents certain reliability.
Study on recovery of copper and zinc from cyanide lean solution in a smelting company
Authors: Guanglin Qin , Guangsheng Li , Xingfu Zhu , Tengyue Gao , Yanbo Chen , Qiang Ji , Congquan Yu , Zhongbo Lu , Juntong Zhang , Chao Xu , Mingming Cai
Published: June 2021

In the process of cyanidation of gold concentrate from a smelting company, the content of copper and zinc in the liquid gradually increased. In production, acidizing process is used to treat the lean solution from high copper concentrate, and mixed products containing copper, zinc and other metals are produced. In this paper, the pH value of zinc precipitation is 6.0 and the pH value of copper precipitation is 3.0 through theoretical calculation and experiment. The separation of copper and zinc in the lean solution is realized successfully. The zinc product with grade of 42.97% and the copper product with grade of 58.33% are produced.
Modified preparation, and characteristic of vermiculite as catalysts support for catalytic pyrolysis
Authors: Wang Yiqian , Sun Zhipeng
Published: June 2021

Natural vermiculite, used as layered catalyst support, was modified with different chemical methods, such as acid treatment, introducing into Na+ and organic modification. The vermiculite-based catalysts were characterized by SEM, BET and XRD respect to their images, textures and structures. SEM results presented big pieced of lamellate vermiculite which had complete structure and piled tightly, and the expansion of layer of modified vermiculites. According to XRD results, it had been found that a characteristic peak appeared at 2° compared with natural vermiculite, and the spacing of layers of the modified samples increased obviously. These results corresponded with BET results which modified vermiculites had larger surface area and pore diameter than natural sample. It meant that modification was beneficial to broaden layered structure and modified vermiculites had the potential as catalyst support.