bluuebunny/crossref_metadata_2025 huggingface dataset:
Uno strumento per l'osservazione dell'alleanza terapeutica nelle terapie di coppia e familiari: il SOFTA-o. Validazione italiana
Authors: Porcedda Lucia
Published: March 2023

L'obiettivo del presente articolo è quello di presentare i risultati dello studio di validazione italiana del SOFTA-o (System for Observing Family Therapy Alliances; Friedlander et al., 2006), uno strumento osservativo utile per la valutazione dell'Alleanza Terapeutica (AT) nelle terapie congiunte, familiari e di coppia. Tale strumento si basa sull'osservazione dei comportamenti correlati all'AT raggrup- pati in quattro macro-dimensioni: Coinvolgimento nel Processo Terapeutico, Connessione Emotiva con il Terapeuta, Sicurezza nel Sistema Terapeutico e Sen- so di uno Scopo Condiviso all'interno della Famiglia. Il SOFTA-o rappresenta uno strumento utile a scopi di ricerca, di formazione dei giovani terapeuti fami- liari e di supervisione clinica. Al fine di evidenziare le potenzialità dello strumen- to nella prassi clinica, la parte finale del presente studio si focalizzerà su alcuni esempi di applicazione pratica.
Linee di cura. La mobilità biografica nello spazio del Terzo Settore
Authors: D’ascenzio Anna
Published: March 2023

Nel paper si analizzerà il professionista della cura come un attore sociale che agisce all'interno del Terzo settore. L'attore occupa uno spazio di riproduzione sociale storicizzato da rapporti di forza, alleanze di status, conflitti di ruolo ed economie di scala, in un campo di trasformazioni sociali. In tale spazio, pratiche e retoriche sono da mettere in relazione alla più complessa questione antropolo-gica del dono. Nel testo si proverà a definire qualitativamente il grado di irriflessività/riflessività nella professione di cura (di per sé soggetto relazionale) come dialettica della vulnerabilità tra il richiedente cura e l'operatore sociale. Come già scritto da Pierre Bourdieu rispetto alla formazione dell'habitus, l'agente sociale risulta essere l'effetto di una complessa combinazione di capitali (economici, culturali e relazionali) in un campo economico. Nel nostro caso, egli è oggetto di habitus ma anche di un apriori giuridico definito come Politique de la Ville. La sintetica espressione indica, anche nel caso italiano, una forma di sovranità statuale, geograficamente localizzata, generata della riscrittura del Titolo V nella Costituzione italiana (2001) e dell'elaborazione della Legge 328/2000. Nel testo si proverà a spiegare che entrambi i dispositivi, oltre a con-tribuire alla fine dei Trente Glorieuses, partecipano al diverso funzionamento dello Stato sociale, ma anche alla diversa definizione professionale dell'operatore. Il soggetto/oggetto di tale traiettoria professionale agisce ed è agito dalla norma, all'interno di un processo non lineare e asimmetrico. Un pro-cesso che non gli assicura un posizionamento sociale solido. Metodologicamente, la figura dell'operatore sarà indagata come esito di una traiettoria biografica ordinata da uno status vulnerabile correlato a polisemici ruoli di dipendenza e creatività. .
"Valore di legame" e contrasto alla povertà. Welfare di comunità nel centro storico di Palermo
Authors: Chiodo Emanuela , Coco Antonella
Published: March 2023

L'articolo presenta un caso di studio sul welfare di comunità condotto nell'ambito di una più ampia ricerca sulla povertà e sugli interventi di contrasto ai fenomeni d'impoverimento delle famiglie a Palermo. L'analisi proposta si svi-luppa nel solco della direttrice teorica sui legami sociali come fonte di protezio-ne e riconoscimento sociale per famiglie, individui e comunità. Indipendentemen-te dalla distanza dal centro urbano, le periferie sociali si caratterizzano per la presenza di molteplici fattori di fragilità e disagio sociale e da una debolezza in termini di strutture di opportunità. Nel centro storico di Palermo, il quartiere dell'Albergheria è interessato da si-tuazioni di povertà e di erosione della cittadinanza. Vulnerabilità ed esclusione sociale sono generate dalla non esigibilità di diritti fondamentali, come il lavoro, la casa, l'istruzione, l'accesso alle cure sanitarie. Allo stesso tempo, il quartiere è caratterizzato da un'intensa vivacità per la presenza di numerose organizzazioni di terzo settore che, su più fronti, si impegnano nel contrasto alla povertà e nella costruzione di legami sociali tramite risorse di social support. L'articolo esplora: qual è l'idea di comunità che esse propongono e che ispira gli interventi messi in campo; qual è il contributo generativo delle iniziative di protezione attivate? La molteplicità di attori sociali intercettati con la ricerca ha dato vita a reti di col-laborazione volte alla valorizzazione delle risorse della comunità e alla promo-zione del suo benessere. La presenza di queste reti di prossimità supportiva ha favorito anche una importante risposta solidale durante la pandemia, in seguito all'emergenza sanitaria e al suo impatto sulla vita degli abitanti.
Emerging Duties: Protecting Canadians’ Human Rights Abroad
Authors: Orange Jennifer
Published: March 2023

In Canada (Prime Minister) v. Khadr, the Supreme Court of Canada ruled that the principle of comity should be limited in situations where Canadian officials acting abroad have violated an international human right of a Canadian citizen. In such instances, the Charter applies. In this paper, the author argues that recent international law developments, including the Responsibility to Protect doctrine and its new conception of « sovereignty as responsibility », challenge the prerequisite of Canadian state involvement in the breach. The principle of comity should not be used as a barrier to remedial action for international human rights violations. Section 7 of the Charter should now be interpreted to include the right of Canadians to the protection of their government when their rights are being violated by a foreign state. This right must have internal limits; that is, there must be proportionality between the required governmental response and the harm caused to the Canadian abroad.

Dans l’arrˆet Canada (Premier ministre) c. Khadr, la Cour suprˆeme du Canada a d´eclar´e que le principe de la courtoisie devrait ˆetre restreint dans les situations o`u des responsables canadiens en mission `a l’´etranger ont viol´e un droit fondamental de la personne reconnu en droit international d’un citoyen canadien. Dans de tels cas, la Charte s’applique. Dans cet article, l’auteure soutient que de r´ecents d´eveloppements en droit international, notamment le concept de la responsabilit´e de prot´eger et la nouvelle conception de la « souverainet´e en tant que responsabilit´e », remettent en question l’exigence d’une participation de l’Etat ´ canadien dans la violation. Le principe de la courtoisie ne devrait pas devenir un empˆechement aux mesures correctrices dans les cas de violation des droits internationaux de la personne. L’article 7 de la Charte devrait maintenant s’interpr´eter de fa¸con `a inclure le droit des Canadiens `a ˆetre prot´eg´es par leur gouvernement lorsque leurs droits sont viol´es par un Etat ´ ´ etranger. Ce droit devrait comprendre des limites internes, c’est-`a-dire qu’il devrait y avoir un lien de proportionnalit´e entre l’action gouvernementale requise et le pr´ejudice caus´e au Canadien situ´e `a l’´etranger 
The Work that Remains: Continuing the Reconciliation Work of Legal Tribunals through Museums
Authors: Orange Jennifer
Published: March 2023

There is no substitution for seeing something with your own eyes. Attending the Woodland Cultural Centre and touring the Mohawk Institute added an indelible texture to the TRC Workshop and to my thoughts about the long-term work of truth and reconciliation. Seeing the physical space where children were held, abused, and some killed, and meeting and listening to the experiences of survivors has brought an urgency to my work that no amount of reading these histories in books and journals could ever do. Even though I had attended the Truth and Reconciliation Commission of Canada event in Montreal in 2013 and listened to dozens of people testify about their experiences in residential schools, there was something different about being in the very place where the children had lived. While I can empathize with the desire of some student-survivors to destroy the physical buildings where such widespread harm was inflicted, as an outsider I gained a new level of understanding from seeing the space, and I hope that these buildings will be preserved so that generations of people may also do so. 
Elon Musk’s Twitter Blue fiasco: Governments need to better regulate how companies use trademarks
Authors: Mogyoros Alexandra
Published: March 2023

[First paragraphs]: "Until recently, Twitter’s blue checkmark logo was (for better or worse) a trusted mark of authenticity. But under the façade of democratizing the platform, Elon Musk allowed the blue checkmark to be purchased by anyone — with unsurprisingly chaotic results.

Impersonators soon made use of the blue checkmark, with negative consequences for those brands, companies and public figures who had their Twitter accounts impersonated."

Article also appeared in the National Post.
Barton jury instructions may raise racial prejudice
Authors: Franks Scott
Published: March 2023

The Supreme Court of Canada’s recent ruling is a reminder of the need to go beyond normative ideals of “reconciliation” and challenge foundational beliefs about the justice system for Indigenous people. 
Enhancing Climate Adaptation through the Paris Agreement Market Approaches: Opportunities for COP 25 and Beyond
Authors: Campbell-Duruflé Christopher
Published: March 2023

This article analyses the draft modalities for the two market approaches to implementing the Paris Agreement, which will be negotiated at the Conference of the Parties in Santiago de Chile in December 2019 and possibly beyond. The author starts by arguing that emissions trading through the International Transfer of Mitigation Outcomes and the Sustainable Development Mechanism may have a variety of impacts on climate adaptation by communities in both transferring and acquiring states. He then identifies the provisions of the draft modalities that are directly and indirectly relevant to the market-adaptation nexus. The author argues that these provisions offer limited potential to hold Parties accountable for the actions taken to protect and enhance adaptive capacity. He shows that more work is needed to ensure that any safeguards adopted are translated into the everyday practice of Parties and stakeholders, and identifies specific instances where greater clarity and specificity are needed.
Recycling performance of softwood and hardwood unbleached kraft pulps for packaging papers
Authors: Simões Rogério M.S. , Ferreira Catarina I.A. , Pires FIlipa , Martins Margarida , Ramos Ana , Sousa António P.M. , Pinto Paula C.R. , Jorge Ricardo
Published: March 2023

The scope of this work is to evaluate the recyclability potential of hardwood and softwood unbleached kraft pulps, leading to a sound basis for comparison and even to support a decision about fibers according to the performance achieved. The influence of successive recycling cycles (up to 10 cycles) on the fiber morphology, pulp suspension drainability, water retention capacity, and handsheet mechanical properties were studied for Eucalyptus globulus and Pinus sylvestris unbleached kraft pulps. The performance of these pulps as linerboard and corrugating medium for packaging was also evaluated. The requirements for brown kraftliner and for high performance recycled fluting grades is preserved for E. globulus pulp during all 10 recycling cycles, evidenced by the moderate decrease of burst index and crush resistance index and by the short-span compression index, whereas the P. sylvestris pulp loses this rating after the second cycle. These results strongly support the higher performance of E. globulus pulp for recycling as compared with softwood kraft pulp from the perspective of packaging papers.
SPEECH PRODUCTION IN ENGLISH BY STUDENTS WITH HEARING IMPAIRMENT: AN ACOUSTIC PHONETIC APPROACH
Authors: Anggraeni Diana , Lubis Donal Fernado , Wulansari Dini
Published: March 2023

Children with special needs have taken wider attentions in research, especially in finding solutions of how to improve their abilities in communication. The purpose of this research is to identify the challenges and barriers in speech production in English by students with hearing impairments in Pangkalpinang City. Investigation and documentation were the main stages in collecting data. The data were studied using a descriptive method with a qualitative approach. Based on the foundation of phonetic theory by Collins and Mess (2019) regarding speech production and the character of children with hearing impairment by Dennis Fry, this research is aimed at analyzing the sounds produced by children with special needs. Experimental observation using the Praat voice analyzer was carried out on students with three types of disabilities: students with vision impairment, hearing impaired, and mental or intellectual disability. The observation results showed that students with hearing impairments (partial and total deafness) were the main concern as their abilities in perceiving and producing speech gave them opportunities to communicate in English despite the barriers, they had to face in pronouncing the words. As conclusion, students with hearing impairment both partial and total deafness produced their speech based on other vocal tracts due to their disability, and certain treatment in speech production should be suggested especially the phonemes involving internal articulators, including alveolar, velar, post-alveolar and nasal sounds. Proximities made in speech showed possibilities to refine their pronunciation.
ILLEGAL ABORTION IN INDONESIAN MEDIA: A CONTENT ANALYSIS
Authors: Susiati Susiati , Udasmoro Wening , Saktiningrum Nur
Published: March 2023

Abortion is a complex issue. On the one hand, abortion is an illegal act according to positive law and is prohibited by religion in Indonesia. On the other hand, abortion is a shortcut to solving unwanted pregnancies by married and unmarried couples. This study aims to see how the media frames news about illegal abortion, how positive law regulates this act and what the triggers doing illegal abortion. This research is qualitative research with a content analysis approach. The results of the study show that the media tends to be neutral by not taking sides between the perpetrators and the victims. This research also reveals the fact that the high demand of the Indonesian people for an illegal abortion service is at least triggered by two things, the legal system, and social norms applied in Indonesia. The legal system prohibiting abortion in Indonesia is incapable to prevent and provide a deterrent effect against perpetrators of abortion criminalization. In addition, Indonesian society’s system of social norms is very sensitive to immoral cases, such as pregnancy out of wedlock. As a result, many pregnant women who are out of wedlock choose to hide their pregnancies and then secretly carry out illegal abortions
THE TEXTUAL THEME POTRAYED ON THE TALKS OF EDUCATION IN THE INDONESIAN TEDX: A SYSTEMIC FUNCTIONAL LINGUISTICS APPROACH
Authors: Nugraha Danang Satria
Published: March 2023

This study sought to describe education-related conversations or talks of education (TE) from a systemic functional linguistics (SFL) perspective, focusing on how textual themes were deployed by speakers. TEDx talk, a reliable online source, was chosen as the source for the data used to support this study. The analysis’s validated data was the transcription of an education-related speech. Documentation, transcription, and in-depth textual fragmentation were the three primary techniques utilized during data processing and analysis. This study demonstrates, based on its findings, that the textual theme was not utilized in all portions of speech; it was the type of theme for which the speaker was required to provide further information. Despite the limitations of performance, a particular construction and functionalization have been applied to the textual theme. There were phrasal and clausal formulations of textual themes, as well as their role within multiple themes
MORPHOSYNTACTIC ABILITIES IN CHILD WITH INTELETUAL DISABILITIES: CASE STUDY
Authors: Pambayun Kumaralalitya Wisnu , Subiyanto Agus
Published: March 2023

The case study in this study used a subject named KH with mild intellectual disability which was seen through the subject's morphosyntactic abilities. In this study using the assessment method to determine the ability of KH in morphology and syntax when speaking in everyday life. The researcher asked KH to tell KH's daily activities and was asked to retell from the available pictures. From this research it can be concluded that KH in making sentences is capable and in accordance with sentence elements such as Subj-Pred-Obj-Ket-Conj. But in terms of morphological abilities, KH more often uses Pred with basic words in the sentences that are spoken than with affixed verbs. So that in that case it can cause confusion of meaning
صورة الجمهورية الإسلامية الإيرانية في الصحافة العراقية المستقلة
Authors: حسن حسام حبيب , دبخ وداد غازي
Published: March 2023

يصنف هذا البحث من ضمن البحوث الوصفية، إذ اعتمد الباحث على المنهج المسحي واستخدام أداة تحليل المضمون وأداة الملاحظة كما تحدد مجتمع البحث بالصحافة العراقية المستقلة التي تمثلت بصحف (الزمان، الدستور، المدى)، وقد اعتمد الباحث أسلوب الحصر الشامل للأعداد الصادرة ضمن المدة الزمنية من (1/10/2019ـ 31/1/2020).

وقد بينت نتائج البحث أن تدخل إيران في شؤون العراق الداخلية كانت من أبرز مكونات رسم الصورة التي تسعى الصحف العراقية المستقلة الى رسمها عن الجمهورية الإسلامية الإيرانية.
CNS Aspergillosis
Authors: Asif Dewan Shamsul , Akther Sumiya , Salam Safwat Binte , Rahman Siddiqui Md Mahmudur , Chowdhury Tasnim Haque
Published: March 2023

Cerebral aspergillosis has the tendency to occur in immune-compromised patients. Less commonly, immune-competent individuals can be affected, with neuroimaging findings being difficult to interpret. A surgical excision with aggressive antifungal therapy is required for a proper management. This case report describes an immune-competent patient with cerebral aspergillosis that presented radiologically as a suspicious mass to be diagnosed pathologically and excised surgically.

AKMMC J 2021; 12(2): 107-112
Dry Matter and Pod Yield of French Bean Varieties As Influenced by Various Nitrogen Application
Authors: Moniruzzaman M , Khatoon R
Published: March 2023

Nitrogen (N) requirement of French bean (Phaseolus vulgaris L.) in Bangladesh is not yet determined. The present study has evaluated the performance of French bean varieties and nitrogen rates through a field experiment conducted at the research field of Plant Physiology Section of Horticulture Research Centre, Bangladesh Agricultural Research Institute (BARI) during rabi seasons of 2016- 17 and 2017-18). The experiment was set up with frenchbean varieties BARI Jharshim-1 and BARI Jharshim-2 and N rates viz., 0, 75, 100, 125 and 150 kg N/ha arranged in a randomized complete block design, with three replications. The variety BARI Jharshim-1 treated with 150 kg N/ha produced the highest in respect of shoot dry matter yield (879.65 g/m2), number of pods/plant (29.70), weight of pods/plant (147.20 g) and green pod (marketable) yield of 19.48 t/ha); in contrast, lower yield and yield attribute was obtained with BARI Jharshim-2 with 125 kg N/ha. Pods of both varieties showed appreciable amounts of protein, vitamin-C and vitamin-A when N was fertilized at 125 followed by 150 kg/ha.

Bangladesh J. Agril. Res. 46(4): 425-433, December 2021
Perception About Household Decision-Making Process on Obtaining Maternal Health Services Among the Employed Women of Dhaka City
Authors: Hossain A H M Kishowar , Dana Gaylan Peyari Tarannum
Published: March 2023

Reducing maternal morbidity and mortality and ensuring maternal and new-born health have been one of the central goals of healthcare system in Bangladesh. In that connection care during and after pregnancy, especially antenatal and delivery, is critical to monitor the status of pregnancy both for mother as well as for expected new-born baby. The role of women’s decision-making in reproductive health is crucial one. This study intends to understand the role of household decision-making in obtaining maternal health services- its patterns access and reasons by using qualitative methods. The approaches are employed to explain woman’s decision-making process to utilize the service facilities. The findings of the study illustrate that decision-making processes should be understood and recognized in a wider social environment and as a multifaceted process that is closely tangled with local belief systems and social relationships. Combined knowledge of social images, women’s requirements and expectations can play an important role in confirming broader and more effective coverage of maternal healthcare, health authorities and to those in charge of maternal care services.
Social Science Review, Vol. 38(2), December 2021 Page 105-116
Fertility Preservation in Patients with Endometrial Cancer
Authors: Topçu Hasan Onur , Oskovi Zeynep Aslı , Meydanlı Mehmet Mutlu
Published: March 2023

Endometrial carcinoma (EC) is the most common gynaecological cancer, with 2-14% of cases occurring in women <40 years of age. When considering the increase in the delay of pregnancy in developing countries, the incidence of EC in nulliparous women is likely to increase. Younger women with EC have a chance to preserve their fertility due to the probability of being diagnosed with early-stage and low- grade endometrioid carcinomas. However, it should be noted that the most important step of fertility preservation in patients with EC is patient selection. The appropriate clinical criteria should include: a) well-differentiated histology; b) absence of myometrial invasion; c) absence of extrauterine or pelvic and pre-aortic lymphatic spread; and d) absence of synchronous ovarian tumour. There is no consensus regarding endometrial suppression therapy or the follow-up period for fertility preservation in women with EC. Therefore, this review aims to evaluate the current literature.
Sperm Motility and Viability: Overview of the Cellular and Physiological Aspects That Support These Functions
Authors: Sati Leyla , Huszar Gabor
Published: March 2023

This review briefly summarises the cellular and physiological aspects of sperm motility (SM) and viability from the point of view of male fertility/infertility. We discuss the SM patterns and maturation processes during the epididymal transit, including the effects of seminal plasma proteins, and while moving through the female reproductive tract. In connection with SM and viability, the oxidative stress, the mitochondrial markers of SM and related predictive value of the proportion of motile sperm, and the effect of male age on sperm function are reviewed within the current literature. Furthermore, some of the potential techniques to determine molecules involved in sperm motion are presented. Other key points are sperm maturation and the markers of sperm maturity, including sperm-hyaluronic acid binding and DNA integrity, as well as the proportion of hyaluronic acid-bound sperm with respect to sperm morphology and tyrosine phosphorylation. Finally, proteins regulating SM and assessment approaches of sperm viability are pointed out in this review.
Creepy Little Girl
Authors: Macfarlane Karen E.
Published: March 2023

The Creepy Little Girl is a subset of the Gothic Child and as such, she works differently from the evil child or the monstrous child in contemporary Gothic. Unlike the contradictions inherent in representations of the evil child whose presence is disruption and destruction, or the monstrous child who is dangerous, the Creepy Little Girl serves as a function of the Gothic: she is that figure through which the narrative is unsettled and the Gothic intrudes. The Creepy Little Girl is defined by her hypergendered position in the narratives in which she appears: as both ‘little’ and very much as ‘girl’. The little girl's presence in contemporary gothic narratives destabilises the familiar, the domestic, and the cute and that is the basis for the gothic unease that she engenders.
Troubled Boundaries: Corporeal and Territorial Transgression in Hunger (Steve McQueen, 2008) and ’71 (Yann Demange, 2015)
Authors: Wynne-Walsh Rebecca
Published: March 2023

The legacy of the Troubles is still patently visible in Ireland. This period has never been absent from contemporary national discourse and, in fact, exists in living memory for the majority of the Irish. Brexit and the passing of Nobel Peace Prize laureate John Hume in August 2020 have only reinvigorated discussions on the Troubles, the IRA, and the Northern Irish peace processes, in which Hume was a central figure. This article presents a critical approach to the Troubles within a Gothic framework. This mode has long articulated anxieties engendered by the irresolvability of contested histories, territories and memories. I argue that the films Hunger and ’71 use gothic narrative structures and motifs to negotiate the emotionally and ideologically loaded Northern Irish conflict. Formally, the Gothic comes to the fore in each film's preoccupation with the unspoken and the visually untrustworthy. Both films rely on fractured chronologies and flashbacks to re-present lingering Northern Irish personal and collective traumas. I position Hunger and ’71 as essential components of an ongoing process of trauma negotiation in regards to the deep-set cultural wounds of the Troubles.
Edukasi Pengobatan Sendiri (Swamedikasi) Siswa/Siswi Sekolah Menengah Kejuruan “Bina Nusa Mandiri” Jakarta Timur
Authors: Chusun Chusun , Poppy Indrianti , Nuha Nabila
Published: March 2023

Vocational High School students are a group of people who are growing up and need knowledge about self-medication which, if done correctly, can assist the government in improving public health status. Self-medication Education Activities at Vocational High School "Bina Nusa Mandiri" - Jakarta, implemented in class XII, Multi Media major with 32 students is a new thing, even though most of the students at the time of brain storming had have done self-medication. Before starting the education the participants were given a Pretest questionnaire for 10 minutes and continued with education which was delivered orally using power point media followed by questions and answers. After the questions and answers were finished, the resource person also made a quiz, with questions about self-medication and prizes were given to participants who could answer correctly
FORMULASI SEDIAAN SABUN CAIR EKSTRAK LIDAH BUAYA (Aloe vera L.)
Authors: Mahayuni Made Galih Dwi , Putra I Gusti Ngurah Agung Windra Wartana , Wintariani Ni Putu
Published: March 2023

Skin is the external part of body which protects internal organs from external interference, such as bacteria, viruses, cold air, hot sun, exposure to UV radiation, pressure, etc. Maintain clean skin is an important thing to do to prevent skin diseases. The way to keep our skin clean is use a mild soap which is good for the skin. Soap is one of the preparations commonly used in daily life. The ingredients of liquid soap are made up of surfactants, thickeners, preservatives and pH regulators. The presence of surface-active agents in soap is important for cleansing the dirt from the skin. Thickeners are important in the soap to obtain the required viscosity of the formulation.

The aim of this study was to determine the characteristics of aloe vera (Aloe Vera L.) liquid soap. This type of research is an experimental study with a completely randomized design. The formula will be tested for physical and chemical properties which include organoleptic tests, viscosity tests, specific gravity tests, foam stability tests, and pH tests. Aloe vera liquid soap in all formulas has physical and chemical characteristics that meet the standards where the viscosity values obtained are 2616-4188 cP, specific gravity 1.067-1.082, foam resistance 61-70%, and pH 6.1-7
ANALISIS DESKRIPTIF TERKAIT PENGETAHUAN PENGGUNAAN ANTIBIOTIK PADA WARGA RW 009 KELURAHAN DUREN SAWIT PERIODE MEI-JUNI 2022
Authors: Fidia Fachdiana , Tuahuns Farida , Niode Harum Andini Putri
Published: March 2023

Infectious diseases remain one of the world's public health concerns, particularly in developing countries. Excessive and inappropriate antibiotics use can lead to the emergence of bacterial resistance and increase the economic burden of health care; additionally. According to a preliminary survey conducted on residents of 009 Community Unit, Duren Sawit Sub-district aged 17-65 in January 2022, it demonstrated that 60% residents believed that antibiotics could treat fever and could be purchased without a prescription 40%. This research aimed to describe the knowledge of antibiotic use in the residents of 009 Community Unit, Duren Sawit Village. The study employed a descriptive quantitative type, where data collection was performed using a questionnaire. This research comprised 237 respondents, who were selected employing the proportional random sampling technique and required the inclusion criteria. The study’s findings indicated that out of 237 respondents, 99 individuals (42%) had good comprehension, 88 individuals (37%) had sufficient comprehension, and 50 individuals (21%) had inadequate comprehension. In summary, suppose described in each indicator, the level of public knowledge for the three indicators was as follows:  118 respondents (50%) have a good understanding of the meaning of antibiotics,104 respondents (44%) have a good understanding of the use of antibiotics, and 140 respondents (59%) had a good understanding of the undesirable effects of the use of antibiotics. The 4 most consumed antibiotics were Amoxicillin (55.7%), Fg Troches (14.3%), Cefixime (8.4%) and Azithromycin (8.4%). While the dose of taking antibiotics ranges from 1x to 4x a day, depends on the type of antibiotics.
PROFIL PENGETAHUAN PENDUDUK TERHADAP OBAT GENERIK, MEREK DAN PATEN
Authors: Rissa Mexsi Mutia , Puspita Nabila Ayu
Published: March 2023

Republic of Indonesia Law Number 36 of 2009 states that medicine is a combination of ingredients, including biological products that are used to affect or investigate physiological systems or pathological conditions in the framework of establishing a diagnosis, prevention, cure, recovery, health promotion and contraception for humans. Generic drugs are drugs whose patents have expired, so all pharmaceutical companies can produce them without the need to pay for patents. Branded drugs are drugs that are marketed under certain trade names registered by the manufacturer. Patented drugs are drugs that have just been produced and marketed by a pharmaceutical company that has had patents for 20 years. The purpose of this study was to determine the profile of the population's knowledge of generic drugs, branded drugs, and patent drugs. The descriptive observational research method by collecting primary data through questionnaires. The results of the study showed that 45 respondents (64.70%) had enough knowledge and 25 respondents (35.70%) had less knowledge. This shows that the profile of the population's knowledge of generic drugs, branded drugs, and patent drugs is considered quite good. The conclusion of this study is that the population's knowledge profile of generic drugs, branded drugs, and patented drugs is included in the sufficient category, namely 64.70%.
KANDUNGAN BORAKS PADA PENTOL BAKSO DI KECAMATAN BALONGBENDO KABUPATEN SIDOARJO DENGAN METODE SPEKTROFOTOMETRI
Authors: Sari Adinda Puspita , Setyawati Herni , Zaenudin Djelang
Published: March 2023

Sodium  Tetraborate, also known as Borax, is a chemical compound which is a derivative of metal boron gas (B), used as an antifungal compound, wood preservative, and an antiseptic compound in cosmetics. The use of Borax as a preservative in food has been banned by the government. The purpose of this study was to help and remove the levels of borax found in meatball bulbs. Sampling was determined in Balongbendo District, Sidoarjo Regency. Analysis of the content of Borax compounds in meatball bulbs was carried out qualitatively using the flame method and the tumeric paper test. Quantitative test using the UV-Vis Spectrophotometer method. Based on the results of an analysis of 60 samples of meatball bulbs sold in Balongbendo District, Sidoarjo Regency, 1 sample was positively identified as containing a Borax compound with an average level of 0.162 ppm.
Effects of topical fluoride application on oral microbiota in young children with severe dental caries
Authors: Yang Zhengyan , Cai Ting , Li Yueheng , Jiang Dan , Luo Jun , Zhou Zhi
Published: March 2023

While the effect of fluoride on severe early childhood caries (S-ECC) is clear, knowledge of how it influences the oral microbiota and the consequential effects on oral health is limited. In this cohort study, we investigated the changes introduced in the oral ecosystem before and after using fluoride varnish in 54- to 66-month-old individuals (n=90: 18 children were sampled at 5 different time points). 16S rDNA was amplified from bacterial samples using polymerase chain reaction, and high-throughput sequencing was performed using Illumina MiSeq platforms. Many pronounced microbial changes were related to the effects of fluoride varnishing. The health-associated Bacteroides and Uncultured_bacterium_f_Enterobacteriaceae were enriched in the saliva microbiome following treatment with fluoride varnishing. Co-occurrence network analysis of the dominant genera showed that different groups clearly showed different bacterial correlations. The PICRUSt algorithm was used to predict the function of the microbial communities from saliva samples. The results showed that starch and sucrose metabolism was greater after fluoride use. BugBase was used to determine phenotypes present in microbial community samples. The results showed that Haemophilus and Neisseria (phylum Proteobacteria) was greater before fluoride use. We conclude that the changes in oral microbiology play a role in fluoride prevention of S-ECC.
Conjunctival sac microbiome in anophthalmic patients: Flora diversity and the impact of ocular prosthesis materials
Authors: Zhao Hejia , Chen Yanjun , Zheng Yixu , Xu Jing , Zhang Chenyu , Fu Min , Xiong Ke
Published: March 2023

Purpose

To explore the changes of bacterial flora in anophthalmic patients wearing ocular prosthesis (OP) and the microbiome diversity in conditions of different OP materials.

Methods

A cross-sectional clinical study was conducted, involving 19 OP patients and 23 healthy subjects. Samples were collected from the upper, lower palpebral, caruncle, and fornix conjunctiva. 16S rRNA sequencing was applied to identify the bacterial flora in the samples. The eye comfort of each OP patient was determined by a questionnaire. In addition, demographics information of each participant was also collected.

Results

The diversity and richness of ocular flora in OP patients were significantly higher than that in healthy subjects. The results of flora species analysis also indicated that in OP patients, pathogenic microorganisms such as Escherichia Shigella and Fusobacterium increased significantly, while the resident flora of Lactobacillus and Lactococcus decreased significantly. Within the self-comparison of OP patients, compared with Polymethyl Methacrylate (PMMA), prosthetic material of glass will lead to the increased colonization of opportunistic pathogens such as Alcaligenes, Dermabacter and Spirochaetes, while gender and age have no significant impact on ocular flora.

Conclusions

The ocular flora of OP patients was significantly different from that of healthy people. Abundant colonization of pathogenic microorganisms may have an important potential relationship with eye discomfort and eye diseases of OP patients. PMMA, as an artificial eye material, demonstrated potential advantages in reducing the colonization of opportunistic pathogens.
Pains and portends: A collaborative autoethnography of engineering faculty navigating gendered cultures
Authors: Miller Callie A. , Castaneda Daniel I. , Alemán Melissa Wood
Published: March 2023

This mediated collaborative autoethnography uses reproduced dialogue, poetic inquiry, and composite, fictionalized narratives to story the gendered experiences of two instructional faculty teaching a coordinated engineering class and working in an undergraduate engineering program at a large public university. The contrasting, gendered narratives of the engineering faculty storied in this paper illuminate several themes: (1) discourses of gendered relational labor (masculinized savior vs. feminized emotional work); (2) gendered experiences of invisibility (not being heard or recognized for expertise) and hypervisibility (as a woman in engineering); and (3) the discounting and attempted diminishment of gendered issues in organizational settings. While self-reflexive and dialogic practices embodied in this autoethnography reveal the transformative possibility of accomplices in disrupting gendered relations of power and activating social change from within, those practices alone are insufficient to trouble the masculine culture of engineering. Authentic change demands that these practices be joined with structural, organizational changes in order to reconcile disparate, gendered experiences in engineering cultures, lest the exodus of women from masculine-dominant engineering fields persist unabated.
Association of red cell distribution width with the risk of 3-month readmission in patients with heart failure: A retrospective cohort study
Authors: Gu Fang , Wu Han , Jin Xiaoli , Kong Cheng , Zhao Wenyan
Published: March 2023

Background

In recent years, red cell distribution width (RDW) has been found to be associated with the prognosis of patients with heart failure (HF) in Western countries. However, evidence from Asia is limited. We aimed to investigate the relationship between RDW and the risk of 3-month readmission in hospitalized Chinese HF patients.

Methods

We retrospectively analyzed HF data from the Fourth Hospital of Zigong, Sichuan, China, involving 1,978 patients admitted for HF between December 2016 and June 2019. The independent variable in our study was RDW, and the endpoint was the risk of readmission within 3 months. This study mainly used a multivariable Cox proportional hazards regression analysis. Smoothed curve ﬁtting was then used to assess the dose-response relationship between RDW and the risk of 3-month readmission.

Results

In the original cohort of 1,978 patients with HF (42% male and 73.1% aged ≥70 years), 495 patients (25.0%) were readmitted within 3 months after discharge. Smoothed curve ﬁtting showed a linear correlation between RDW and the risk of readmission within 3 months. In the multivariable-adjusted model, every 1% increase in RDW was associated with a 9% increased risk of readmission within 3 months (hazard ratio = 1.09, 95% confidence interval: 1.00–1.15; P < 0.005).

Conclusions

A higher RDW value was significantly associated with a greater risk of 3-months readmission in hospitalized patients with HF.
Prevalence of diabetes in the USA from the perspective of demographic characteristics, physical indicators and living habits based on NHANES 2009-2018
Authors: Fang Ling , Sheng Huafang , Tan Yingying , Zhang Qi
Published: March 2023

Objective

To determine differences in DM in the U.S. population according to demographic characteristics, physical indicators and living habits.

Methods

23 546 participants in the 2009 to 2018 National Health and Nutrition Examination Survey (NHANES) who were 20 year of age or older and not pregnant. All analyses used weighted samples and considered the stratification and clustering of the design. Specific indicators include length of leg (cm), BMI (kg/cm2), TCHOL (mg/dL), fasting plasma glucose (mg/dL) and comparison of means and the proportion of participants with DM.

Results

The prevalence of DM in the USA has been rising modestly in the past decade, and were consistent and robust for the observed differences in age, sex, and ethnicity. Compared with white participants, black participants and Mexican-American were both more likely (P<0.001) to have diabetes: 14.6% (CI, 13.6% to 15.6%) among black participants, 10.6% (CI, 9.9% to 11.3%) among white participants, and 13.5% (CI, 11.9% to 15.2%) among Mexican-American participants. The prevalence of diabetes is increasing with age, males peaked around the 60s, and women around the 70s. The overall mean leg length and TCHOL was lower in diabetics than in non-diabetics (1.07 cm, 18.67 mg/dL, respectively), while mean BMI were higher in diabetics than in non-diabetics (4.27 kg/cm2). DM had the greatest effect on decline of TCHOL in white participants (23.6 mg/dL), less of an effect in black participants (9.67 mg/dL), and the least effect in Mexican-American participants (8.25 mg/dL). Notably, smoking had great effect on percent increment of DM in whites (0.2%), and have little effect on black and Mexican-Americans.

Conclusions

DM is more common in the general population than might be clinically recognized, and the prevalence of DM was associated to varying degrees with many indicators of demographic characteristics, physical indicators, and living habits. These indicators should be linked with medical resource allocation and scientific treatment methods to comprehensively implement the treatment of DM.
Revisiting artificial intelligence diagnosis of hepatocellular carcinoma with DIKWH framework
Authors: Shen Xiaomin , Wu Jinxin , Su Junwei , Yao Zhenyu , Huang Wei , Zhang Li , Jiang Yiheng , Yu Wei , Li Zhao
Published: March 2023

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high morbidity and fatality rate. Traditional diagnostic methods for HCC are primarily based on clinical presentation, imaging features, and histopathology. With the rapid development of artificial intelligence (AI), which is increasingly used in the diagnosis, treatment, and prognosis prediction of HCC, an automated approach to HCC status classification is promising. AI integrates labeled clinical data, trains on new data of the same type, and performs interpretation tasks. Several studies have shown that AI techniques can help clinicians and radiologists be more efficient and reduce the misdiagnosis rate. However, the coverage of AI technologies leads to difficulty in which the type of AI technology is preferred to choose for a given problem and situation. Solving this concern, it can significantly reduce the time required to determine the required healthcare approach and provide more precise and personalized solutions for different problems. In our review of research work, we summarize existing research works, compare and classify the main results of these according to the specified data, information, knowledge, wisdom (DIKW) framework.
Spatial and Multilevel Analysis of Unscheduled Contraceptive Discontinuation in Ethiopia: Further analysis of 2005 and 2016 Ethiopia Demography and Health Surveys
Authors: Tamirat Koku Sisay , Nigatu Solomon Gedlu , Tesema Getayeneh Antehunegn , Sisay Malede Mequanent , Tessema Zemenu Tadesse
Published: March 2023

Background

Unscheduled discontinuation of contraceptives is a public health problem among women of reproductive age. Particularly, it is associated with unwanted pregnancies that lead to maternal and child mortality, but little is known about the spatial distribution of the problem. Therefore, this study aims to assess the spatial distribution and associated factors of unscheduled contraceptive discontinuation in Ethiopia.

Method

This study used secondary data from the Ethiopia Demography and Health Survey (EDHS) data of 2005 and 2016. The study population was women who used contraceptives in the preceding 5 years before the survey. A total of 2,327 and 3,858 eligible women were included in the final analysis of the 2005 and 2016 EDHS, respectively. For the spatial analysis, both the 2005 and the 2016 EDHS data were analyzed using ArcGIS version 10.7, while for multilevel regression analysis, the 2016 EDHS data were used. The final model reported an adjusted odds ratio (AOR) with a 95% confidence interval (CI), and a p-value of 0.05 was used to declare statistical significance.

Result

This study revealed that unscheduled discontinuation of contraceptives varied geographically, and hotspots were detected in the central, north, and eastern parts of Ethiopia. Moreover, diploma and higher education (AOR = 1.40; 95% CI: 1.01–1.95), urban residence (AOR = 1.37; 95% CI: 1.08–1.72), history of termination of pregnancy (AOR = 1.47; 95% CI: 1.14–1.94), married women (AOR = 10.79; 95% CI: 6.98–16.69), separated/divorced women (AOR = 1.54: 95% CI: 1.07–2.30), —two to four number of children (AOR = 1.46; 95% CI: 1.15–1.84), and involvement in the decision-making process of contraceptive use (AOR = 39.26; 95% CI: 28.84–53.45) were all factors associated with unscheduled discontinuation of contraceptives.

Conclusion

This study revealed that unscheduled discontinuation of contraceptive distribution was significantly clustered in the central, north, and eastern parts of Ethiopia, as found in two surveys. The magnitude of this discontinuation increased from 2005 to 2016. The finding underscores that further interventions such as the availability of multiple mixed methods and improvement in women's decision-making ability in the choice of contraceptive methods and utilization are needed in hotspot areas of Ethiopia.
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells
Authors: Masle-Farquhar Etienne , Jeelall Yogesh , White Jacqueline , Bier Julia , Deenick Elissa K. , Brink Robert , Horikawa Keisuke , Goodnow Christopher Carl
Published: March 2023

Introduction

Germline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell lymphomas (PTCL) adult T cell leukemia/lymphoma (ATL), cutaneous T cell lymphoma (CTCL) and Sezary Syndrome. Despite their frequent acquisition by PTCL, the T cell-intrinsic effects of CARD11 GOF mutations are poorly understood.

Methods

Here, we studied B and T lymphocytes in mice with a germline Nethyl-N-nitrosourea (ENU)-induced Card11M365K mutation identical to a mutation identified in DLBCL and modifying a conserved region of the CARD11 coiled-coil domain recurrently mutated in DLBCL and PTCL.

Results and discussion

Our results demonstrate that CARD11.M365K is a GOF protein that increases B and T lymphocyte activation and proliferation following antigen receptor stimulation. Germline Card11M365K mutation was insufficient alone to cause B or T-lymphoma, but increased accumulation of germinal center (GC) B cells in unimmunized and immunized mice. Card11M365K mutation caused cell-intrinsic over-accumulation of activated T cells, T regulatory (TREG), T follicular (TFH) and T follicular regulatory (TFR) cells expressing increased levels of ICOS, CTLA-4 and PD-1 checkpoint molecules. Our results reveal CARD11 as an important, cell-autonomous positive regulator of TFH, TREG and TFR cells. They highlight T cell-intrinsic effects of a GOF mutation in the CARD11 gene, which is recurrently mutated in T cell malignancies that are often aggressive and associated with variable clinical outcomes.