bluuebunny/crossref_metadata_2025 huggingface dataset:
Pray to the Archive: Abstracting History in Zanzibar
Authors: Kara Taushif
Published: May 2020

This article explores the problem of reading architecture as archive, with specific reference to the built environment on the island of Zanzibar. The architecture of Stone Town – Zanzibar's urban centre – is often marshalled by scholars as clear evidence of the island's complex and layered histories. This reading, however, tends to lament an erstwhile Indian Ocean cosmopolitanism at odds with both the Zanzibari past and present. In this article, I trace the contours of the island's divergent political and architectural histories and demonstrate how an archival view of architecture can obscure the very past it seeks to recover. I illustrate this tension through one particular case study: the Khoja Jamatkhana in the heart of Stone Town. I then consider the possible futures of archival readings by exploring the limits of both formal analysis and historical context through the work of contemporary artist Zarina Bhimji. If the Jamatkhana points to the restrictive capacity of archival readings of architecture, Bhimji's work opens up the archive itself as a site of abstraction, bringing into sharp relief the intricate relationship between space and history.
Records of Dispossession: Archival Thinking and UNESCO's Nubian Campaign in Egypt and Sudan
Authors: Carruthers William
Published: May 2020

This article discusses the creation of architectural and archaeological archives in newly independent Egypt and Sudan during the International Campaign to Save the Monuments of Nubia, organized by UNESCO (The United Nations Educational, Scientific and Cultural Organization). This initiative took place in the contiguous border regions of Egyptian and Sudanese Nubia from 1960 until 1980 in response to the building of the Aswan High Dam. Contingency in these archives demonstrates the necessity of acknowledging the (post-) colonial social and historical conditions in which they were produced. UNESCO's campaign sought to record ancient remains that would be submerged by the High Dam's floodwaters. During the campaign, UNESCO set up 'documentation centres' that helped codify what knowledge about Nubian architecture/archaeology might be archive-worthy, producing index cards dedicated to this purpose in Egypt (concentrating on monuments) and Sudan (centring on archaeological sites). This practice – echoed by other organizations involved in the work – was often purposefully forgetful of contemporary Nubia, whose material traces were also soon to be flooded. Nevertheless, such practices rendered visible other unauthorised histories of Nubia that subverted archival knowledge production: histories of local involvement with the campaign and now-submerged Nubian settlements. This article therefore argues that it is not only possible, but also ethically imperative, to repurpose the Nubian campaign's archives towards the acknowledgement of erased Nubian histories.
Illite crystallinity index an indicator of physical weathering of the Sediments of the Tista River, Rangpur, Bangladesh
Authors: Saha Sudip , H. M. Selim Reza A. , Kanti Roy Mrinal
Published: May 2020

The Tista River is a tributary of the Brahmaputra River. The deposits that exposed along the both banks of the Tista River are characterized mainly by sand, sand laden with gravel and pebble with minor amounts of silt and clay. The X-ray Diffraction (XRD) of the clay sized sediments of the Tista River reveals that illite (and/or mica), chlorite, kaolinite, quartz and feldspar are the principal mineral constituents. The minor to trace amounts of lavendulan, glauconite lepidolite, enstatite, sekaninaite and ferrierite minerals were identified in the investigated area. Illite constitutes 36% of the total minerals of the Tista River basin. The values of the illite crystallinity index varies from 0.228 to 0.345, indicating that the illites are relatively well crystallized and derived from the mechanical weathering of pre-existing rocks. The presence of illite and kaolinite suggests their derivation from the crystalline rocks that contain feldspar and mica, as well as from the pre-existing soils and sedimentary rocks. Glauconite forms in the sediments of continental shelf in the marine environment. The accessory minerals like enstatite, sekanianite and ferrierite are derived from basic igneous rocks. The dissolution of copper arsenate mineral, lavendulan might be a source of arsenic in the sediments of the study area.
REFORMASI BIROKRASI PADA LINGKUNGAN PERADILAN AGAMA DI INDONESIA
Authors: Ibrahim Malik
Published: May 2020

This article describes the development and change of Religious court in Indonesia as a fruit of bureaucratic reform in the period of Reformation era. Concentrating on the reformation of the institution, human resource, and infrastructure, this article argues that the bureaucratic reformation of Religious Court has brought about some positive impact to the Religious Court of Indonesia. The Religious Court becomes more independent and professional. Its professionalism is indicated by the on time process of the court, the increasing quality of human resources, and better infrastructure. Meanwhile, its independency is strengthened by the implementation of one roof system which put the Religious Court merely under the coordination of Supreme Court of the Republic of Indonesia.Artikel ini berupaya mendeskripsikan perubahan yang terjadi di lingkungan  Peradilan Agama (PA) melalui Program Reformasi Birokrasi yang dilaksanakan pada era Reformasi dengan fokus kajian tentang perbaikan layanan dan manajemen  dari aspek kelembagaan, sumber daya manusia, struktur organisasi, sarana dan prasarana, kesejahteraan aparat  serta peraturan perundangan yang mengatur tentang PA.  Tulisan ini menunjukkan bahwa hasil dari reformasi birokrasi di lingkungan PA telah menjadikan PA sebagai sebuah lembaga yang lebih professional dan mandiri. Profesionalitas PA ditujukan dengan meningkatnya ketepatan waktu dalam proses peradilan, sumber daya manusia yang semakin berkualitas dan perbaikan sarana dan prasarana PA. Sedangkan kemandirian PA ditunjukkan dengan system peradilan satu atap dengan menempatkan kedudukan PA langsung di bawah Mahkamah Agung.
PANDANGAN TOKOH MASYARAKAT MUSLIM BONE TERHADAP PENGGUNAAN ALAT KONTRASEPSI MODERN SEBAGAI UPAYA MENGURANGI TINGKAT KELAHIRAN
Authors: , Samsidar
Published: May 2020

Family planning is one of the government programs aiming to decrease the rapid population growth rate in Indonesia. This paper examines the views of Bone Regency Muslim community leaders on the use of modern contraceptives as an effort to reduce birth rates. Primary data was obtained by interviews and secondary data obtained from the Bone Regency Population and Family Planning Control Institute (P2KB). The results showed that there were differences opinions of Muslim community leaders on the contraception. Some argued that the use of modern contraception is forbiden because it is not in line with the law of God. The rest had an opinion that family planning has some benefits. Therefore  the use of the contraception is not prohibited as long as it does not change God's creation.Salah satu program pemerintah yang dipopulerkan untuk menekan laju pertumbuhan penduduk yang pesat adalah Keluarga Berencana. Tulisan ini mengkaji tentang pandangan tokoh masyarakat muslim Kabupaten Bone mengenai penggunaan alat kontrasepsi modern sebagai upaya mengurangi tingkat kelahiran. Sumber data primer dari wawancara dan data sekunder bersumber dari Lembaga Pengendalian Penduduk dan Keluarga Berencana (P2KB) Kabupaten Bone. Data diolah secara kualitatif, dengan pendekatan normatif. Hasil penelitian menunjukkan bahwa terdapat perbedaan pandangan dari tokoh masyarakat muslim terhadap kontrasepsi. Sebagian berpendapat bahwa penggunaan alat kontrasepsi tidak diperbolehkan karena bertentangan dengan sunnatullah. Sedangkan yang lain berpendapat bahwa penggunaan alat kontrasepsi untuk mengatur kelahiran lebih mendatangkan manfaat, lebih lagi bagi orang miskin. Oleh karena itu, penggunaan alat kontrasepsi tidak bertentangan dengan hukum Islam, selama alat kontrasepsi tersebut tidak merubah ciptaan Tuhan.
YUDISIALISASI DAN LIMITASI HUKUM ISLAM: CERAI TALAK DI PENGADILAN AGAMA DI LOMBOK
Authors: Nasir Mohamad Abdun , Sunardi Heru
Published: May 2020

Male repudiation (cerai talak) at religious courts reveals important changes in contemporary practice of Islamic law in Indonesia. This paper addresses two salient features of repudiation, namely judicialization and limitation. Based on empirical studies at the religious courts in Lombok, this study gathered the data on repudiation through observation, interview and documentation. The data shows changing practice and meaning of Islamic marital dissolution due to judicialization, that is an administrative and bureaucratic processes of legal settlement at religious courts. Upon the introduction and application of modern codification of Islamic law, such as the Compilation of Islamic Law (Kompilasi Hukum Islam/KHI) enacted by Presidential Decree No. 1/1991 and Religious Judicature Act No. 7/1989 at religious courts, the influence of fiqh on Islamic divorce has diminished significantly. Such application not only creates judicialization but also causes limitation on the number of male repudiation, outnumbered by female-initiated divorce (cerai gugat). Talak, which is male domain under the conception of fiqh, is now a contested terrain by legal actors, such as men (husbands), women (wives) and judges. Consequently, judicialization of talak has reduced not only male power but also its practice at the religious courts.Cerai talak di pengadilan agama mencerminkan perubahan-perubahan penting dalam penerapan hukum Islam kontemporer di Indonesia. Artikel ini membahas dua fenomena mengemuka praktik talak, yaitu yudisialisasi dan limitasi. Berangkat dari penelitian empiris di pengadilan agama di Lombok dengan metode pengumpulan data melalui observasi, wawancara dan dokumentasi, penelitian ini meyingkap pergeseran pemaknaan dan praktik talak kontemporer. Hal ini disebabkan oleh yudisialisasi, yaitu proses administrasi dan birokratiasasi penyelesaian perkara di pengadilan agama. Pasca diperkenalkannya kodifikasi hukum keluarga Islam, seperti Kompilasi Hukum Islam melalui Instruksi Presiden No. 1/1991 maupun Undang-undang Peradilan Agama No. 7/1989, pengaruh fikih dalam hukum perceraian Islam berkurang secara signifikan seiring dengan pemberlakuan kodifikasi di pengadilan agama. Implikasinya bukan saja pada yudisialisasi, akan tetapi juga limitasi talak, yakni terbatasnya perkara cerai talak dibanding cerai gugat. Talak yang dalam norma fikih menjadi domain kuasa suami yang hampir mutlak, kini dalam praktiknya di pengadilan agama menjadi wilayah yang dikontestasikan oleh para aktor hukum, baik suami, istri maupun hakim sehingga berdampak pada limitasi talak, baik dari segi kuantitas perkara maupun kuasa suami dalam penyelesaian cerai talak.
LEFT: LOCAL EDGE FEATURES TRANSFORM
Authors: Tikhomirova T. A. , Fedorenko G. T. , Nazarenko K. M. , Nazarenko E. S.
Published: May 2020

To detect point correspondence between images or 3D scenes, local texture descriptors, such as SIFT (Scale Invariant Feature Transform), SURF (Speeded-Up Robust Features), BRIEF (Binary Robust Independent Elementary Features), and others, are usually used. Formally they provide invariance to image rotation and scale, but this properties are achieved only approximately due to discrete number of evaluable orientations and scales stored into the descriptor. Feature points preferable for such descriptors usually are not belong to actual object boundaries into 3D scenes and so are hard to be used into apipolar relationships. At the same time, linking the feature point to large-scale lines and edges is preferable for SLAM (Simultaneous Localization And Mapping) tasks, because their appearance are the most resistible to daily, seasonal and weather variations.In this paper, original feature points descriptor LEFT (Local Edge Features Transform) for edge images are proposed. LEFT accumulate directions and contrasts of alternative strait segments tangent to lines and edges in the vicinity of feature points. Due to this structure, mutual orientation of LEFT descriptors are evaluated and taken into account directly at the stage of their comparison. LEFT descriptors adapt to the shape of contours in the vicinity of feature points, so they can be used to analyze local and global geometric distortions of a various nature. The article presents the results of comparative testing of LEFT and common texture-based descriptors and considers alternative ways of representing them in a computer vision system.
ALGORITHM OF CROSS LANGUAGE FUZZY SEARCH BASED ON HASH-VECTORS FOR AUTOMATIC COMPARISON OF PERSONAL NAMES
Authors: Vakhromova E. Yu. , Beketova I. V. , Gerasimenko A. A. , Goremychkin V. I. , Krivoshlyapov V. P.
Published: May 2020

The algorithm of cross language fuzzy search based on hash vectors for automatic matching of personal names is proposed. In the response mode for an input request, names in Latin spelling and a given value for the similarity measure, the algorithm determines the set of output Cyrillic names contained in the database of the information search system. The principal feature of the proposed algorithm is the rejection of the direct translation of personal names. Instead, the hashing mechanism of personal names is used, followed by mapping them into the same hidden vector space where the computational procedures of the decision-making system are built. In the process of research, it was solved a number of actual intermediate tasks. Thus, the decomposition algorithms of the explored database, the generation and clustering of the dictionary of basic morphemes are an instrument that is of independent value in solving the problem of automatically translating names from a foreign language, the translation rules of which are unknown – the socalled generalized transcription. After mapping names into a vector space, the matching operation is reduced to assessing the similarity between vectors. As a measure of similarity, several quantities were considered in the study. The most convenient measure of similarity is the cosine similarity, the critical value of which was obtained by plotting the FMR (False Match Rate) and FNMR (False Non-Match Rate) graphs. The developed algorithm is universal with respect to the languages used, that is, it does not depend on a specific alphabet. In the practical implementation of the developed algorithm, a series of experimental studies was carried out using a database containing more than 2.5 million names.
CLASSIFICATION OF NETWORK PROTOCOLS WITH APPLICATION OF MACHINE LEARNING METHODS AND FUZZY LOGIC ALGORITHMS IN TRAFFIC ANALYSIS SYSTEMS
Authors: Ermakov R. N.
Published: May 2020

This paper presents a new effective approach to analyzing network traffic in order to determine the protocol of information exchange. A brief description of the structure of the algorithm for classifying network packets by belonging to one of the known network protocols is given. To define the protocol, the principle of high-speed one-packet classification is used, which consists in analyzing the information transmitted in each particular packet. Elements of behavioral analysis are used, namely, the transition states of information exchange protocols are classified, which allows to achieve a higher level of accuracy of classification and a higher degree of generalization in new test samples. The topic of the article is relevant in connection with the rapid growth of transmitted traffic, including malicious traffic, and the emergence of new technologies for transmitting and processing information. The article analyzes the place of traffic analysis systems among other information security systems, describes the tasks that they allow to solve. It is shown that when recognizing the internal state in which a particular protocol may be in the process of information exchange at the handshake stage, a classifier of network packets of the application level can be useful. To classify network packets, we used fuzzy logic algorithms (Mamdani model) and machine learning methods (neural network solutions based on logistic regression). The paper presents 4 stages of developing a network packet classifier – monitoring and collecting packet statistics of the most famous network traffic protocols, preprocessing primary packet statistics, building a classifier for network packets and testing. The test results of the constructed software module capable of identifying network protocols for information exchange are demonstrated.
The effect on the psychological perception of exercise in female inmates
Authors: Köse Elif , Yerlisu Lapa Tennur
Published: May 2020

The aim of this study is to identify the psychological perception levels of the female inmates in Antalya Type-L Closed Penitentiary Institution and then to determine the effect of exercise on such perceptions. This is an experimental study with weak experimental design. Study sample consists of a total of 121 female prisoners; 32 in the experimental group, 43 in control group 1 and 46 in the control group 2. The data collection tools used in this study are Physical Activity Readiness Questionnaire for determining the physical activity levels of the individuals, Psychological Well-Being Scale, Beck Depression Inventory and State-Trait (STAI) Anxiety Inventory for identifying their psychological perceptions. T-Test, One-Way Analysis of Variance and LSD analysis -a Post-Hoc test- were used for data analysis. Consequently, the psychological perception levels of the female inmates before and after exercise were examined as per the groups they participated and the results revealed that there was no statistically significant difference among the depression, anxiety and psychological well-being levels of those inmates, who participated in the exercises. However, there was a significant increase on the depression levels in the control groups 1 and 2. In conclusion, it can be said that exercise plays an important role in protecting the psychological perceptions of the incarcerated individuals.
School counselors’ opinions, knowledge and competencies on substance addiction
Authors: Çetinkaya Yıldız Evrim
Published: May 2020

In this study, school counselors’ opinions, knowledge and competencies on substance addiction were investigated. Three hundred and forty school counselors participated in the study. Findings stated that, school counselors consider substance addiction as a problem in Turkey. It was found out that the participants' level of knowledge about how to communicate with addicted students and their parents is relatively higher than their level of knowledge about substance abuse and addiction treatment. In addition, the findings indicated that participants considered themselves as more competent on implementing preventive studies and assessing addicted students but they found themselves less competent in subjects related to substance addiction. Lastly, the results revealed that school counselors with professional experience between six to ten years have been found to report significantly higher level of knowledge and competence in some items than school counselors with fewer and more seniority.

​Extended English summary is in the end of Full Text PDF (TURKISH) file.

 

Özet

Bu çalışmada okul psikolojik danışmanlarının madde bağımlılığı konusundaki görüşleri, bilgileri ve yeterlikleri araştırılmıştır. Araştırmaya üç yüz kırk psikolojik danışman katılmıştır. Bulgular psikolojik danışmanların Türkiye’de madde bağımlılığını bir sorun olarak gördüklerini ortaya koymuştur. Psikolojik danışmanların madde bağımlılığı olan öğrenciye ve öğrencinin velisine nasıl yaklaşılması gerektiği ile ilgili bilgi düzeylerinin madde bağımlılığı ve bağımlılık tedavisi ile ilgili bilgi düzeylerinden daha iyi olduğu tespit edilmiştir. Psikolojik danışmanların koruyucu önleyici çalışmalar yapma, bağımlı öğrencileri tespit etme ve sigara bağımlısı öğrencilerle çalışma konularında kendilerini daha yeterli gördükleri ancak uyuşturucu madde ve alkol bağımlılığı ile ilgili konularda çalışma konusunda kendilerini daha az yeterli gördükleri belirlenmiştir. Son olarak, altı ile on yıl arasında kıdemi olan psikolojik danışmanların madde bağımlılığı ile ilgili rapor ettikleri bazı bilgi ve yeterliklerinin daha az ve daha fazla kıdemli meslektaşlarının rapor ettikleri bilgi ve yeterlik düzeylerinden anlamlı derecede daha yüksek olduğu ortaya çıkmıştır.
Integrated transcriptome and microRNA profiles analysis reveals molecular mechanisms underlying the consecutive monoculture problem of Polygonatum odoratum
Authors: Chen Yong , Liu Zhi , Tu Naimei , Hu Yihong , Jin Chenzhong , Luo Yucai , Liu Aiyu , Zhang Xianwen
Published: May 2020

Polygonatum odoratum is a historically traditional Chinese medicine plant. However, the consecutive monoculture problem (CMP) widespread in other Chinese medicine limiting their cultivation on a large scale. In this study, the physiological data showed the adverse effect of CMP on the growth of P. odoratum under the consecutive cropping (CC) compared with the first cropping (FC). Then the high-throughput sequencing of miRNA and mRNA libraries of leaves and roots from FC and CC P. odoratum plants identified 671 differentially expressed genes (DEGs) and 184 differentially expressed miRNAs and revealed that the DEGs and target genes of the miRNAs were mainly involved in starch and sucrose metabolism, phenylpropanoid and brassinosteroid biosynthesis. The KEGG analysis revealed that the DEGs between CC and FC roots were enriched in the plant-pathogen interaction pathway. This study provided the expression regulation of genes related to CMP of P. odoratum but also suggested that CMP may result in the serious damage of pathogens to roots and cause the slow growth in the consecutive cropping plants.
Comprehensive hematological reference intervals in a healthy adult male population
Authors: Ghazizadeh Hamideh , Kathryn Bohn Mary , Kardagh Polus Ranan , Abdulkarimi Rahim , Mahdavizadeh Vahid , Ghaffarian Zirak Roshanak , Kamel Khodabandeh Atieh , Zare-Feyzabadi Reza , Timar Ameneh , Mohammadi-Bajgiran Maryam , Oladi Mohammad Reza , Esmaily Habibollah , Sharifan Payam , Sahranavard Toktam , Kazemi Elham , Ekhteraee Toosi Mansoureh Sadat , Taghizadeh Niloofar , Najar Sedgh Doust Fatemeh , Ferns Gordon A. , Adeli Khosrow , Ghayour-Mobarhan Majid
Published: May 2020

Reference intervals (RIs) are important tools for improving medical decision-making. Hematology reference values can be influenced by important covariates such as genetic and environmental factors, rendering it essential to define RIs for specific populations. Therefore, we aimed to establish accurate and robust RIs for hematological markers in a healthy adult male Iranian population. This cross-sectional study was conducted in a population of 723 males aged 20-60 years old. Hematological parameters were routinely measured using a Sysmex auto analyser system (KX-21 N). The quality of assays was monitored using commercial quality control samples. The nonparametric rank method, as recommended by the Clinical and Laboratory Standards Institute (CLSI) guidelines, was used to calculate the 2.5th and 97.5th percentiles as the lower and upper reference limits, respectively. Of the 12 hematological parameters assessed, only mean platelet volume (MPV) demonstrated significant age-specific differences, requiring two partitions from 20 to 35 years (8.7-12.2 fL) and 35 to 65 years (8.5-11.5 fL). The remaining hematological parameters (e.g. leukocyte, erythrocyte, and platelet parameters) could be defined by one age range. This study established RIs for 12 routinely used hematological parameters in a healthy male population living in the northeastern region of Iran. Established RIs differed from those previously reported by other cohorts, highlighting the importance of population-specific RIs.
Expression levels of blood platelet and C-reactive protein in patients with severely pneumonic and their predictive values for efficacy
Authors: Li Lihong , Ren Baozhong , Guo Jian , Zhang Zhicang , Cai Yuxing , Yin Jie
Published: May 2020

This paper aims to detect the expression levels of blood platelet (PLT) and C-reactive protein (CRP) in severely pneumonic patients and analyze their correlation. For this purpose, eighty-one severely pneumonic patients were retrospectively selected as an observation group and 106 healthy people as a control group. Pretreatment and post-treatment expression levels of PLT and CRP, their predictive values for efficacy, and correlation of PLT, CRP, and PSI scores in observation group after treatment were analyzed. Before treatment, the expression level of PLT in the observation group was higher than the control group (P< 0.05). In the observation group, the expression level of PLT after treatment was significantly lower than that before treatment (P< 0.05). Before treatment, the expression level of CRP in the observation group was higher than the control group (P< 0.05). In the observation group 1) the pretreatment PLT expression level was higher than that in the control group; 2) the post-treatment PLT expression level was significantly lower than that in the pretreatment one; 3) the pretreatment CRP expression level was higher than that in the control group; and 4) the post-treatment CRP expression level was significantly lower than the pretreatment one (All P-values< 0.05). Based upon the efficacy, the observation group was divided into an effective group and an invalid group. The post-treatment expression levels of PLT and CRP in the effective group were lower than those in the invalid group (P< 0.05). Based upon the ROC curve, the area under curves (AUC) of PLT, CRP, and joint detection were 0.843, 0.864, and 0.886, respectively. When the cut-off point was > 0.579, the best specificity and sensitivity were 98.44 and 70.59%, respectively. According to the Pearson test, positive correlations existed between PLT and CRP, between PLT and PSI scores, and between CRP and PSI scores. In conclusion, the expression levels of PLT and CRP in severely pneumonic patients might be used to evaluate the efficacy and conducive to detection of the disease, which have high application values in clinic.
Rubimaillin suppresses proliferation, migration and invasion of prostate cancer cells via the Notch-1/MMP signaling pathway
Authors: Cai Fangzhen , Guo Shuxin , Huang Sihuai , Li Jianwei , Liu Wenbin
Published: May 2020

This study was aimed to explore the effect of Rubimaillin on the survival, migration, and invasion of prostate cancer cell lines DU145 and PC3, and its mechanism. CCK-8 method was used to detect the effects of different concentrations of rubs (0, 5, 10, 20, 40 and 80 Î¼M) on the activity of DU145 cells and PC3 cells. Transwell cell lab test was used to detect the migration and invasion of cells. Western blot was used to detect Notch-1, MMP-2, MMP-9 and Hes-1 protein levels. The CCK-8 assay showed that Rub inhibited the activity of Du145 and PC3 cells in a concentration dependent manner. When the concentration reached 40 Î¼M, the inhibition reached the maximum. After Rub intervention, the migration and invasion ability of Du145 and PC3 cells decreased significantly, while the expression levels of Notch-1, MMP-2, MMP-9 and Hes-1 protein decreased significantly. Rub can inhibit the growth, migration and invasion of prostate cancer cell line DU145 and PC3. The mechanism may be related to the inhibition of Notch-1, MMP-2, MMP-9 and Hes-1 by Rub.
Effect of miR-124 on PI3K/Akt signal pathway in refractory epilepsy rats
Authors: Wang Ruili , An Xuelin , Zhao Shuzhi
Published: May 2020

This research aimed to investigate the effect of miR-124 on the PI3K/Akt signaling pathway in refractory epilepsy rats. Ten healthy SD rats were selected as a control group, thirty-six successfully established model rats were randomly divided into the model group, mir-124-agomir, mir-124-antagomir, mir-124-agomir+ LY294002 group (combined group), with 9 rats in each group. PI3K or (and) Akt expressions were intervened respectively. The changes in attack latency and cognitive function were observed, and the correlation among miR-124, PI3K, Akt, and attack latency was analyzed. Up-regulation of the level of miR-124 could increase the seizure interval of rats (P< 0.05), improve the cognitive function of rats (P< 0.05), and promote the expression of PI3K, AKT. The level of miR-124, PI3K, Akt was positively correlated with the latent time of seizures in rats, and the level of miR-124 was positively correlated with the level of PI3K, Akt (P< 0.05). In conclusion, miR-124 can play a protective role in temporal lobe epilepsy by promoting PI3K/Akt signaling pathway, including the protection of cognitive function, which may be a potential target for clinical treatment of intractable epilepsy in the future.
Effect of glutamine on the immune function of paclitaxel intervention in ovarian cancer mice
Authors: Wang Li , Li Yanfen , Wang Juan
Published: May 2020

To analyze the effect of amide Valley on the immune function of ovarian cancer mice treated with paclitaxel. Fifty SPF female BALB/c mice were selected as experimental subjects, and the mice were divided into five groups, namely normal control group, tumor control group, paclitaxel group, glutamine group and combined intervention group, with 10 mice in each group. Except for the normal control group, the other 40 mice were all subjected to ovarian cancer modeling. After modeling, the tumor control group mice were injected with saline at a dose of 25 mg/kg; the mice in the paclitaxel group were given a dose of 25 mg/kg. Intraperitoneal injection of paclitaxel; mice in the glutamine group were intraperitoneally injected with glutamine at a dose of 25 mg/kg; mice in the joint intervention group were intraperitoneally injected with glutamine and paclitaxel at a dose of 25 mg/kg once daily. The normal control mice did not receive any treatment. Observe and compare the status of the five groups of mice and regularly measure the quality of the mice; after 2 weeks of treatment, the CD3+, CD4, CD4+, CD8, CD8+ of the T lymphocyte subsets of each group of mice were detected by flow cytometry calculate the ratio of CD4 / CD8. The tumor formation rate of mouse ovarian cancer was 95% (38/40). The hair color, diet, excretion and activity of mice in the normal control group were normal, while the hair of the remaining four groups of ovarian cancer mice was sparse and dull compared with those in the normal control group, and the diet was decreased and the action was retarded. By measuring the body mass of mice at a regular time, we found that before treatment, the body mass of the other four groups of ovarian cancer mice increased significantly (P< 0.05) because of the tumor body compared with the normal control group mice; after treatment, compared with the other ovarian cancer mice group, the body mass of the combined intervention group mice decreased significantly, the difference was statistically significant (P< 0.05), suggesting that the tumor body was reduced. Compare with normal control mice, CD3+, CD4, and CD4 / CD8 of other ovarian cancer mice groups were significantly decreased, and CD8+ was significantly increased, the differences were statistically significant (P< 0.05); There was no significant difference in the levels of CD3+, CD4+, CD4 / CD8, and CD8+ between the tumor control group and the paclitaxel group (P> 0.05). Paclitaxel does not improve the immunity of patients during the treatment of ovarian cancer. Glutamine is effective immunomodulation. By regulating paclitaxel-treated ovarian cancer mice, it can simultaneously treat ovarian cancer, significantly improve the immune function of ovarian cancer mice, thereby improving the anti-tumor ability, and provide the possibility of significantly improving the body's immunity of ovarian cancer patients. Clinical research and long-term prognosis still need to be confirmed by further studies.
Inhibition characteristics of biofilm structure of Staphylococcus aureus
Authors: Zhang Liping , Jin Mingxiao , Sun Meng
Published: May 2020

Different extracts have different effects on the biofilm structure of Staphylococcus aureus, and the biofilm structure of Staphylococcus aureus will produce different inhibition reactions. In this study, different experimental reagent extracts were used to analyze the inhibition characteristics of Staphylococcus aureus biofilm structure. The inhibition characteristics of bacterial biofilm structure were obtained by using the same bacteria species and the same experimental environment. The results showed that the chloroform extract had a good inhibitory effect on the biofilm structure, which could effectively inhibit the formation of biofilm; the acetic acid extract had an impact on the formation of biofilm, which was destructive to the biofilm; the petroleum ether extract had no effect on the formation of biofilm, that is, it had no inhibitory effect.
Expression of miR-93-5p in patients with esophageal carcinoma and its relationship with the curative effect and prognosis of radiotherapy
Authors: Chen Lingzhi , Fan Xinhua , Wang Xiangming , Wu Xianhua
Published: May 2020

This study aimed to investigate the expression of miR-93-5p in esophageal carcinoma-patients and its relationship with the curative effect and prognosis of radiotherapy. 102 patients with esophageal carcinoma treated in Yiwu Central Hospital from May 2013 to July 2015 were considered as the experimental group, and 89 healthy people for physical examination during the same period were selected as the control group. The expression of miR-93-5p in the serum of the two groups was compared. Based on the mean expression of miR-93-5p in serum, esophageal carcinoma patients were divided into high expression and low expression groups. Then the relationship between clinical-pathological characteristics and the expression of miR-93-5p was analyzed. The curative effect of radiotherapy in patients with esophageal carcinoma was evaluated, and the relationship between the expression of miR-93-5p, the curative effect of radiotherapy and the 3-year survival rate in patients with esophageal carcinoma was analyzed. The expression of miR-93-5p in the serum of the experimental group was significantly higher than that of the control group (P< 0.05); there was a significant correlation between the expression of miR-93-5p and pathological stage (P< 0.05). The expression of miR-93-5p in the effective radiotherapy group was significantly lower than that in the ineffective radiotherapy group (P< 0.05). ROC curve showed that the sensitivity and specificity of miR-93-5p in predicting radiotherapy response of esophageal carcinoma were 88.57 and 64.69% respectively, AUC was 0.864 (95%CI:0.791~0.936), P< 0.001; the 3-year survival rate of low expression group was significantly higher than that of high expression group (P< 0.05). In Conclusion, the expression of miR-93-5p was high in esophageal carcinoma patients, and the higher the expression, the worse the curative effect of radiotherapy and the worse the prognosis, which may be a new predictor of radiotherapy effect and prognosis in patients with esophageal carcinoma.
Microarray analysis of preterm preeclampsia
Authors: Liu Huina , Yu Junjie , Yuan Wenjing , Shi Huirong , Guan Wenli
Published: May 2020

Premature preeclampsia is the second cause of maternal mortalities around the world. To investigate its potential driving mechanism(s), we constructed a multi-regulatory-mediated preeclampsia dysfunction module. Through combining differential expression analysis, co-expression analysis, and enrichment analysis, we obtained 23 sets of preeclampsia expression disorder modules in the disease, which involve the modular aggregations of 3016 genes. The modules were subjected to be analyzed for GO and KEGG paths for enrichment analysis. Based on these pivotal regulators, it is possible to manipulate the essential parts of the modular subnetwork and study their cooperative acts to mediate the driving mechanism of the preeclampsia. Simultaneously, they mainly cause the onset of the disease through the regulation of the apoptotic signaling pathway, down-regulation of an inflammatory response and retinol metabolism. This may present a potential driving mechanism for the disease. The predictor analysis of the regulators showed a series of non-coding RNAs that have potentially significant regulatory effects on the disease, including miR-182-5p, miR-200b-3p, miR-23a-3p, miR -429, miR-590-3p, and transcription factors. These pivotal regulators might mediate the potential driving processes. Based on a comprehensive multivariate analysis, we found a possible driving mechanism in which significant pivotal regulators were used as distinct functional segments in the preterm preeclampsia-driven process.
Grain productive efficiency of soybean plants under lactofen application
Authors: Da Rosa Willian Pelisser , Caverzan Andreia , Chavarria Geraldo
Published: May 2020

Adverse factors cause a decrease in the productive potential of crops. For soybean [(Glycine max (L.) Merrill], the excessive growth is a factor that results in plants with low effective efficiency. Thus, plants with an architecture that favours greater interception of solar radiation and deposition of pesticides tend to be more productive. The objective of this study is to evaluate the different application of lactofen, which is used as a growth inhibitor, improve the productive efficiency of soybeans by increasing the biological activity of the leaves. The study was conducted in the field with soybean cultivars NA 5909 RG and BMX Potência RR. The experiment followed a randomized complete block design with four treatments and five replicates: T1: control; T2: application of 140 g a.i ha-1 of lactofen in phenological stage V3; T3: application of 140 g a.i ha-1 of lactofen in phenological stage V6; and T4: application of 70 g a.i ha-1 of lactofen in phenological stage V3 + 70 g a.i ha-1 of lactofen in phenological stage V6. The interception of photosynthetically active radiation in the lower layer increased in all treatments. Lactofen application increased the percent area covered and the number of phytosanitary products spray droplets per cm² in the middle and lower layers of the plants. The lower third of the plants experienced the greatest effect of the treatments with regard to the number of pods, grains and grain weight, with treatment T2 presenting significant increases. The use of lactofen as a growth inhibitor at the beginning of pod development in soybean caused changes to plant architecture and root development, consequently enhanced the productive efficiency of the plant, primarily due to increased grain production in the lower layer. Future research using lactofen in different phenological stages and cultivars may provide more insights in to the performance of this growth inhibitor in soybean.
Factors affecting Chinese university students’ intention to continue using virtual and remote labs
Authors: Zhang Mu-Hua , Su Chien-Yuan , Li Yan , Li Yan-Yan
Published: May 2020

Recently, virtual and remote labs (VRLs) have been developed to support students in conducting experiments in engineering and science education. However, little is known about the students’ intentions to continue using VRLs and their satisfaction with the experience. This study proposed an extended model embedded within the expectation confirmation model and two variables concerning flow experience (time distortion and focused attention) to predict Chinese university students’ satisfaction with and intention to continue using VRLs. A structural equation modelling technique based on covariance was conducted to evaluate survey questionnaire responses received from 238 students at a university located in central China. The results demonstrated that satisfaction was the most crucial determinant of the students’ intention to continue using VRLs, followed closely by perceived usefulness. Confirmation played an indirect role in predicting students’ intentions to continue using VRLs via satisfaction and perceived usefulness. Students’ flow experience while performing virtual experiments played a positive and direct role in confirming their expectations of VRLs.
Characterizing Compatibility of Crumb Rubber Modified Asphalt by Customized Drainage Method
Authors: Li Jin , Wang Jiayu , Xiao Feipeng , Amirkhanian Serji N.
Published: May 2020

The poor compatibility between crumb rubber (CR) and asphalt matrix always brought difficulties to the engineering application of CR modified (CRM) asphalt. The compatibility in CRM asphalt was universally characterized by storage stability test at a macroscale. Actually, the term “compatibility” was introduced to describe the “level of interaction” between the asphalt and polymers in polymer modified asphalt. Therefore, in this study, the compatibility in CRM asphalt (i.e., the level of asphalt-rubber interaction) was newly characterized by removing the CR particles in the CRM binder through a customized drainage process and quantifying the difference between drained asphalt and base asphalt. In practical terms, the changes in the rheological properties and chemical composition of binder relative to base asphalt were measured by dynamic shear rheometer and gel permeation chromatography, respectively. Based on this novel characterization, it was found that smaller CR particles tended to possess greater compatibility with asphalt, and the asphalt with a higher percentage of light fractions was expected to be more compatible with CR particles. On the other hand, the result of the conventional hot tube test found the storage stability mainly depended on the size and content of CR particles. Furthermore, a strong statistical correlation between the novel characterizations (i.e., changes in rheology and chemistry of binder) and the common characterization (i.e., storage stability) was found, and its essential cause was discussed. Therefore, this novel characterization could provide another reliable and simple way to evaluate the compatibility in CRM asphalt.
OLERICULTURA E AGRICULTURA FAMILIAR: RELAÇÃO ENSINO-EXTENSÃO UNIVERSITÁRIA NO OESTE CATARINENSE
Authors: Silva Vanessa Neumann , Bilini Adriana , Munarini Geovani , Junior Dirceu Ferri
Published: May 2020

A Olericultura é uma atividade de grande importância para propriedades de agricultura familiar. Contudo, observa-se que grande parte dos olericultores familiares, tem pouco acesso à extensão rural, realizada por agências governamentais. Desta forma, a extensão universitária tem papel essencial, não somente pelos benefícios que traz ao ensino-aprendizagem, mas por cumprir seu papel na comunidade local. Considerando o exposto, ações de extensão vem sendo realizadas, em propriedades de Agricultura Familiar que possuem foco na produção de hortaliças, na disciplina de Olericultura, do curso de Agronomia, da Universidade Federal da Fronteira Sul. As ações descritas nesse trabalho foram realizadas nos anos de 2017 e 2018. Durante a disciplina, em cada ano, a turma foi dividida em grupos de trabalho, e cada um desses destinado a uma propriedade familiar. Foram realizadas visitas nas propriedades e levantados dados como: histórico, sistemas de produção, culturas produzidas, caracterização do solo, água e recursos naturais, mão-de-obra e formas de comercialização dos produtos. A partir dos levantamentos, os discentes elaboraram projetos técnicos, com sugestões para resolução dos problemas indicados pelos agricultores, com enfoque em métodos sustentáveis. Ao final de cada período de trabalho, realizou-se uma dinâmica, com apresentação das propostas para os agricultores e uma roda de conversa e discussão, sobre a viabilidade de implantação das mesmas. Observou-se resultados promissores, no processo de ensino-aprendizagem dos discentes, obtidos na troca de experiências com os agricultores, assim como a contemplação das necessidades de extensão rural aos agricultores.
Ocupações de leitura em espaços de crise
Authors: Alves Izandra , Branchi Natália , Fernandes Naíma De Sousa
Published: May 2020

Este relato de experiência a partir de práticas extensionistas objetiva explanar acerca de um projeto de leitura denominado “Ocupações de leitura em espaços de crise”, que atua em lugares que são carentes de atividades que envolvam tais práticas. Através de manifestações artísticas, textos verbais e não verbais, chás literários, contação de histórias e rodas de conversa, pretendemos contribuir para a ressignificação dos participantes das ações que voltam o olhar para seus interiores e (re) descobrirem-se como pessoas importantes para os outros e para si mesmos. Como aporte teórico, valemo-nos dos estudos de Michèle Petit e Jorge Larrosa a fim de discutirmos de que maneira, e até que ponto, as experiências com a leitura podem contribuir para a (trans) formação de cada um.
NÚCLEOS DE PRÁTICA JURÍDICA DOS CURSOS DE GRADUAÇÃO EM DIREITO: DO ESTÍMULO À JUDICIALIZAÇÃO A UMA PROPOSTA DE INCLUSÃO
Authors: Filpo Klever Paulo Leal , Emmerick Rulian , Miguens Marcela Siqueira
Published: May 2020

Trata-se de um relatório de atividades de extensão desenvolvidas no Núcleo de Prática Jurídica (NPJ) Instituto Três Rios da UFRRJ, situado no interior do Estado do Rio de Janeiro, associadas ao ensino e à pesquisa. O texto tem duplo objetivo: (1) explicitar uma perspectiva extensionista sobre as atividades de prática jurídica no âmbito dos cursos de Direito, voltadas para a inclusão, à luz das diretrizes curriculares que tratam dessa matéria, e (2) relatar experiências extensionistas em curso no âmbito desse NPJ. Metodologicamente, o texto contém a análise de textos normativos referentes à prática jurídica associada à descrição das atividades de extensão desenvolvidas pelos autores do texto em conjunto com alunos bolsistas e voluntários. Pretende-se fomentar o debate sobre o papel do NPJ e a ampliação das atividades extensionistas nos cursos de Direito.
EXTENSÃO, PESQUISA E CURRÍCULO: A TRAJETÓRIA DA LIBRAS NA UNIVERSIDADE FEDERAL DO MATO GROSSO
Authors: Lord Lucio Jose Dutra , Maiolini Sergio Pereira
Published: May 2020

Este estudo analisa o processo de implementação da Língua Brasileira de Sinais, Libras, na Universidade Federal do Mato Grosso (UFMT), iniciando pela oferta mediante cursos de extensão universitária, passando pela realização de projeto de pesquisa com interface em extensão, e depois se consolidando como disciplina no currículo de cursos de licenciatura e bacharelado. O objetivo do estudo foi investigar o processo histórico pelo qual se deu a implantação da Libras nessa instituição de educação superior para conhecer os avanços e identificar as limitações nessa modalidade de educação inclusiva. A metodologia utilizada foi a revisão da literatura, a análise da legislação, o estudo de documentos internos da universidade e a coleta de dados mediante entrevistas. Os dados coletados indicam que o ingresso da Libras no âmbito da UFMT se deu a partir de duas frentes: um interna, por demandas identificadas pelos docentes; outra externa na medida em que a legislação passou a estabelecer a obrigatoriedade da disciplina nos currículos das licenciaturas. Como conclusão são identificados aspectos que, ao limitarem o ensino/aprendizagem dessa língua, influenciam para uma inclusão parcial dos deficientes auditivos. Como alternativa a esse diagnóstico, o estudo defende a relevância das atividades de extensão como alternativa e como processo indissociável do ensino e pesquisa para a melhoria da formação na educação superior.