bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Coherence of Strict Finitism
Authors: Alesander Auke
Published: September 2022

Strict finitism is the position that only those natural numbers exist that we can represent in practice. Michael Dummett, in a paper called Wang's Paradox, famously tried to show that strict finitism is an incoherent position. By using the Sorites paradox, he claimed that certain predicates the strict finitist is committed to are incoherent. More recently, Ofra Magidor objected to Dummett's claims, arguing that Dummett fails to show the incoherence of strict finitism. In this paper, I shall investigate whether Magidor is successful in preventing Dummett from proving the incoherence of strict finitism. Though not all the counterarguments Magidor presents are successful, she does in the end manage to corner Dummett. There remains an opportunity for Dummett to insist on the incoherence of strict finitism, but this is a very small opening. The final conclusion of this paper is that Dummett cannot logically prove the incoherence of strict finitism, even though a limited chance for success remains.
Beyond A-Theory and the Block Universe: A non-circular derivation of "before", change, and the local arrow of time
Authors: Saudek Daniel
Published: September 2022

This article proposes a "third way" in the philosophy of time beyond A-theory and the block universe, in which time is understood as a purely local phenomenon. It does so by starting with simple metaphysical assumptions about substances and their properties. Based on these assumptions, the notions of "before", of change, and of time as local quantification of change can be derived non-circularly, i.e. without invoking temporal concepts. I then proceed to prove the irreversibility of local time by showing that the propositional content of the local past cannot be changed, since this would imply a contradiction, whereas that of the future can. Time's familiar asymmetric character, in particular the difference between the fixed past and the open or \branching" future, is therefore a non-illusory but purely local phenomenon. Such a model requires no past-present-future distinction valid for the entire cosmos, and is therefore consistent with special and general relativity.
The Determinable-Based Account of Metaphysical Indeterminacy and Vague Identity
Authors: Bĕlohrad Radim
Published: September 2022

This paper focuses on Jessica Wilson's determinable-based account of metaphysical indeterminacy and its relationship to the concept of vague identity. The determinable-based account comprises a distinction between meta-level and object-level accounts of metaphysical indeterminacy. I first argue that the distinction cannot be clearly applied to some theories. In particular, I argue that even though Wilson categorizes the constitution account of metaphysical indeterminacy as a meta-level account, from one perspective it can be defensibly regarded as an object-level account, because it is bound to posit genuinely indeterminate states of affairs and provides an explanation of boundary indeterminacy that is structurally analogous to the explanation provided by Wilson's object-level account. This interim conclusion is important, because it has been argued that the constitution account, when applied to some more complex types of boundary indeterminacy, cannot avoid commitment to vague identity, in spite of the declarations of some of its proponents. The ultimate goal of this paper is to argue that, contrary to Wilson's claims, the determinable-based account must embrace vague identity too.
Why Moral Epistemology is Not Just Epistemology Applied to Moral Beliefs
Authors: Ravish Sushruth , Joshi Chaitanya
Published: September 2022

The current discourse on moral epistemology (ME), has hardly paid any attention to the question concerning the demarcation of the domain of ME within epistemology. Neither is the subject matter of ME considered unique, nor is the methodology adopted in its investigations considered distinct. We attempt to show in this paper that this omission does not restrict itself to a mere taxonomical oversight but rather leads to certain deeper conceptual concerns. We argue that a casual and porous understanding of the subject matter of ME is the result of conflating moral beliefs and justification with non-moral beliefs and justification. If ME doesn't merit a clear demarcation within epistemology, then the very legitimacy of ME is brought under a cloud, thereby threatening the distinction between ethics and epistemology. We believe G. E Moore foresaw this predicament and our interpretation of his work could offer a possible solution.
Construction of special soliton solutions to the stochastic Riccati equation
Authors: Navickas Zenonas , Timofejeva Inga , Telksnys Tadas , Marcinkevicius Romas , Ragulskis Minvydas
Published: September 2022

A scheme for the analytical stochastization of ordinary differential equations (ODEs) is presented in this article. Using Itô calculus, an ODE is transformed into a stochastic differential equation (SDE) in such a way that the analytical solutions of the obtained equation can be constructed. Furthermore, the constructed stochastic trajectories remain bounded in the same interval as the deterministic solutions. The proposed approach is in a stark contrast to methods based on the randomization of solution trajectories and is not focused on the analysis of martingales. This article extends the theory of Itô calculus by directly implementing it into analytical schemes for the solution of differential equations based on the generalized operator of differentiation. The efficacy of the presented analytical stochastization techniques is demonstrated by deriving stochastic soliton solutions to the Riccati differential equation. The presented semi-analytical stochastization scheme is relevant for the investigation of the global dynamics of different biological and biomedical processes where the variation interval of the stochastic solution is predetermined by the rationale of the model.
FromSer Focalizadorand Contrast to the Presuppositional [Verb+Ser+X] Construction in Spanish
Authors: Moya-Chaves Deyanira Sindy
Published: September 2022

This study uses a corpus of conversational speech to describe a structure in Spanish previously known asSer Focalizador(‘Focalizing Be’, hereafter [Verb+Ser+X]). In this structure, the verbser‘to be’ appears after the main verb of the clause. Its function has traditionally been described as indicating what comes after in the sentence as the marked focus. However, by examining how the [Verb+Ser+X] is used in talk-in-interaction it is found that a more particular construction has the function of marking counter-argumentation – i.e., canceling some background inference (presupposition or implicature) – by making the second member of a contrastive pair more clearly contrastive, and establishing a structural distinction which has the pragmatic and contextualeffectof contrast. I call this particular construction presupposition canceling [(NEGclause)(pero ’but’)Verb+Ser+X]. The description provided here is also founded on identifying the linguistic contexts that favor the use of the [Verb+Ser+X], by treating it as a variant of the simple clause with a complement whereserwas absent in the verbal phrase, but could have been present. The analysis of variation provides evidence for the presuppositional [Verb+Ser+X] to be variably conditioned by a propositional X, and by the co-occurrence of previous negation and of the adversative conjunctionpero‘but’. The analysis also offers an operationalization of contrast in conversational data, as well as a definition of the variable context for a pragmatic construction such as the [Verb+Ser+X].
The Syntactic and Discourse Properties of Second Person Singular Forms of Address inPaisaSpanish
Authors: Restrepo-Ramos Falcon , Denbaum-Restrepo Nofiya
Published: September 2022

In this study we examine the linguistic complexity and lexical properties of the discourse associated with second person singular forms of address (2PS) in the Spanish spoken in Medellín, Colombia. This Spanish variety exhibits the use of a tripartite system of 2PS, in whichvoseo,tuteo, andustedeoare used, and sometimes interchanged, according to sociopragmatic factors. By means of a discourse completion task (DCT), 672 responses were collected from 38 informants. Data was parsed and tagged using UDPipe to train an annotation Spanish model. Syntactic and lexical properties were extracted automatically in Python. Results revealed the syntactic properties and the existence of collocations significantly associated with each 2PS. The discourse associated withvosdiffers in terms of the predicate structure, DCT response length, pragmatic function, and use of colloquial speech markers. Results of this work shed further light on the variable use of 2PS in this intriguing Spanish dialect.
Was it a Syro-Ephraimite War?
Authors: Shtaimetz Yaniv
Published: September 2022

2Kings 16:5 describes a siege, laid by Rezin king of Aram-Damascus and Peqah son of Remalia king of Israel, on the Judean capital Jerusalem in the days of Ahaz son of Jotham king of Judah. This siege is known in the research literature as the ›Syro-Ephraimite war‹, named so after the two allies who joined forces against Judah: Aram-Damascus, located in Syria, and Israel, whose power base is traditionally identified with the central hill country of Mount Ephraim. The aim of this short paper is to question the appropriateness of the name given to this war and specifically the power structure it represents. It does so by examining regional power relations and the local Israelite power structure at the time, as well as relevant terminological conventions. This examination sheds new light on Israel’s power base at the time, and produces two more suitable options for naming this biblical event, by identifying the real political power structure and by bringing Judah into the picture.
Was machte Onan mit seinem Sperma? Zur Deutung von

w
e
šiḥ(h)et in Genesis 38,9
Authors: Tropper Josef
Published: September 2022

According to the traditional understanding of Genesis 38:9, whenever Onan would perform the duties of Levirate marriage with Tamar, he would let his sperm »be ruined.« The central verbal form reads: wešiḥ(h)et. In the present contribution this translation is called into question. It will be argued that wešiḥ(h)et here is not to be derived from √šḥt
(1) »to ruin,« but from a different root, namely √šḥt
2 »to let flow, to spurt« (corresponding to the Akkadian šaḫātu »to flow [away], to rinse, to wash«). The text would therefore simply state that Onan ejaculated his sperm onto the ground so as not to impregnate Tamar (coitus interruptus). Should this interpretation be correct, the far-reaching reception history of the text, including the prohibition of any form of »Onanism,« would have to be reassessed.
Subacute thyroiditis post viral vector vaccine for COVID-19
Authors: Casey Caoimhe , Higgins Tom
Published: September 2022

Subacute thyroiditis is an inflammatory disorder of the thyroid gland that has previously been described following viral illnesses and occasionally post vaccination such as influenza vaccine. 2021 was a revolutionary year for the development of SARS-CoV-2 vaccinations with multiple different vaccines now available. There are increasing numbers of case reports of thyroiditis following these vaccinations. We report a case of a 50-year-old female who developed subacute thyroiditis 6 days post ChAdOx1 nCoV-19 vaccine (AZD1222 produced by AstraZeneca Vaxzevria). The initial thyrotoxic phase was followed by overt hypothyroidism. This resolved spontaneously within 5 months without levothyroxine replacement. We hope that our case will add to the growing literature of cases of thyroiditis occurring after multiple different types of SARS-CoV-2 vaccination and create awareness of this rare but treatable adverse effect. We also review the literature on the proposed mechanisms behind this adverse effect.

Learning points

Subacute thyroiditis is an inflammatory disorder of the thyroid gland that can occur after a viral illness or vaccination against certain infections.

Subacute thyroiditis is a rare adverse effect that has been reported to occur after different types of SARS-CoV-2 vaccinations.

Subacute thyroiditis post vaccination is relatively straightforward to manage, with some patients requiring non-steroidal anti-inflammatory drugs and beta-blockers, while more severe cases may require corticosteroid therapy. This adverse effect should not dissuade vaccination use at a population level.

There are many postulated mechanisms for the development of subacute thyroiditis following vaccination including the presence of the ACE-2 receptor for SARS-CoV-2 on the thyroid gland, an inflammatory/immune response as is seen in COVID-19 infection itself and molecular mimicry between SARS-CoV-2 spike protein and healthy thyroid antigen.
Combined SPINK1 mutations induce early-onset severe chronic pancreatitis in a child with severe obesity
Authors: Abass Maha Khalil , Al Shamsi Aisha , Jan Iftikhar , Masalawala Mohammed Suhail Yasin , Deeb Asma
Published: September 2022

The most frequent causes of pancreatitis classically have been known to be gallstones or alcohol. However, genetics can also play a key role in predisposing patients to both chronic and acute pancreatitis. The serine protease inhibitor Kazal type 1 (SPINK 1) gene is known to be strongly associated with pancreatitis. Patients with these underlying genetic mutations can have severe diseases with a high morbidity rate and frequent hospitalization. We report an Arab girl who presented with acute pancreatitis at the age of 7 years progressing to recurrent chronic pancreatitis over a few years. She had severe obesity from the age of 4 years and developed type 2 diabetes at the age of 12. She had a normal biliary system anatomy. Genetic analysis showed that she had combined heterozygous mutations in the SPINK1 gene (SPINK1, c.101A>G p.(Asn34Ser) and SPINK1, c.56-37T>C). Her parents were first-degree cousins, but neither had obesity. Mother was detected to have the same mutations. She had type 2 diabetes but never presented with pancreatitis. This case is the first to be reported from the Arab region with these combined mutations leading to recurrent chronic pancreatitis. It illustrates the importance of diagnosing the underlying genetic mutation in the absence of other known causes of pancreatitis. Considering the absence of pancreatitis history in the mother who did not have obesity but harboured the same mutations, we point out that severe obesity might be a triggering factor of pancreatitis in the presence of the mutations in SPINK1 gene in this child. While this is not an assumption from a single patient, we show that not all carriers of this mutation develop the disease even within the same family. Triggering factors like severe obesity might have a role in developing the disease.

Learning points

Acute recurrent pancreatitis and chronic pancreatitis are uncommon in children but might be underdiagnosed.

Biliary tract anomalies and dyslipidaemias are known causative factors for pancreatitis, but pancreatitis can be seen in children with intact biliary system.

Genetic diagnosis should be sought in children with pancreatitis in the absence of known underlying predisposing factors.

SPINK1 mutations can predispose to an early-onset severe recurrent pancreatitis and acute pancreatitis.
The association between serum concentration of thyroid hormones and thyroid cancer: a cohort study
Authors: Kim Tae-Hwan , Lee Mi Yeon , Jin Sung Min , Lee Sang Hyuk
Published: September 2022

The impact of serum thyroid hormone levels on thyroid cancer risk is unclear. Some studies reported that elevated thyroid-stimulating hormone (TSH) is associated with higher risk for incidence of thyroid cancer, but other studies reported no relationship. We conducted a large cohort study in 164,596 South Korean men and women who were free of thyroid cancer at baseline and underwent health examination with hormone levels of thyroid function. A parametric proportional hazard model was used to evaluate the adjusted hazard ratio (HR) and 95% CI. During 2,277,749.78 person-years of follow-up, 1280 incident thyroid cancers were identified (men = 593, women = 687). Among men, the multivariable-adjusted HR (95% CI) for thyroid cancer comparing low levels of TSH with normal levels of TSH was 2.95 (1.67–5.23), whereas the corresponding HR (95% CI) in women was 1.5 (0.88–2.55). High levels of free T4 and free T3 were also associated with incident thyroid cancer in both men and women. In clinical implication, overt hyperthyroidism is associated with thyroid cancer in both men and women. Within the euthyroid range, the highest tertile of TSH was associated with a lower risk of thyroid cancer than the lowest TSH tertile and the highest FT4 tertile was associated with a higher risk of thyroid cancer than the lowest FT4 tertile in both men and women. Our finding indicates that low levels of TSH and high levels of FT4, even within the normal range, were associated with an increased risk of incident thyroid cancer.
Ionic liquid-assisted isolation of lignin from lignocellulose and its esterification with fatty acids
Authors: Lee Eun-Ah , Kim Jeong-Ki , Bandi Rajkumar , Dadigala Ramakrishna , Han Song-Yi , Kwon Gu-Joong , Gwon Jaegyoung , Youe Won-Jae , Park Ji-Soo , Park Chan-Woo , Kim Nam-Hun , Lee Seung-Hwan
Published: September 2022

Ionic liquids (ILs) have been widely used for lignocellulose fractionation and lignin isolation. However, the effect of IL treatment on lignin structure has been less explored. This study aimed to explore the chemical structure of lignin isolated by widely used imidazolium based ILs and compare it with the well-known milled wood lignin structure (MWL). Four types of ILs were used, and the effects of the treatment conditions on the isolated lignin (ILL) characteristics were evaluated. As the treatment temperature was increased from 60 to 140 °C, the ILL yield increased, whereas the molecular weight and hydroxyl group content decreased. Among the ILs, [EMIM]Ac produced the highest lignin yield (5.28%), and the ILL obtained had the lowest hydroxyl content (1.27 mM/g) and a molecular weight (Mw) of 29,500 g/mol. Esterification of the ILL isolated with [EMIM]Ac was performed using three fatty acid chlorides, octanoyl chloride (C8), lauroyl chloride (C12), and palmitoyl chloride (C16), to extend its applicability. The effects of esterification on the characteristics of ILL were evaluated, and successful esterification was confirmed using Fourier transform infrared and nuclear magnetic resonance spectroscopies.
My Child Is Sick!
Authors: Schmitt Barton D.
Published: September 2022

Prevent unnecessary calls to your office when you share the wisdom of My Child Is Sick! with your parents. The well-organized chapters, condition-specific charts, and clear advice will empower parents to make the right decisions when confronted by common childhood illnesses. Dr. Schmitt's proven guidelines will help parents figure out whether to treat their child at home, call the doctor, or head to the emergency department. Available for purchase at https://www.aap.org/my-child-is-sick-3rd-edition-paperback/
Confixal word-formation rows with the suffix -ment
Authors: Dotsenko Olena
Published: September 2022

This article presents a detailed analysis of the structure of five confixal word-formation rows with the suffix -ment from the synchronous point of view and with the help of the applicative generative model. The confixal word-formation rows are studied in terms of their homogeneity and heterogeneity, complexity and depth. Some theoretical notions such as “word-formation row”, “confix”, “circumfix”, “derivational suffix” and “applicative generative model” are discussed. The paper outlines different interpretations of the origin of the suffix -ment. The article is mainly aimed at analyzing the structure of confixal word-formation rows rather than describing their semantic features.
Cuidados de enfermagem aos recém-nascidos submetidos a fototerapia em unidades neonatais: um protocolo de scoping review.
Authors: Andrade Anny Suelen Dos Santos , Machado Luciara Silva , Silva Valéria Gomes Fernandes da , Oliveira Lahelya Carla De Andrade , Souza Nilba Lima de
Published: September 2022

Objetivo: Mapear a produção do conhecimento sobre os principais cuidados de enfermagem realizados aos recém-nascidos submetidos a fototerapia em unidades neonatais.

Método: Trata-se de um protocolo de revisão de escopo, realizado de acordo com a metodologia do Joanna Briggs Institute e checklist do Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), seguindo as seguintes etapas: seleção da questão de pesquisa; busca por estudos relevantes; seleção dos estudos; extração e análise dos dados; e, agrupamento, resumo e apresentação dos resultados. Para identificar os documentos as seguintes bases de dados bibliográficas serão pesquisadas: Medical Literature Analysis and Retrievel System Online, Cumulative Index to Nursing & Allied Health Literature, Web of Science, SciVerse Scopus, Base de Dados de Enfermagem, Literatura Latino-Americano e do Caribe em Ciências da Saúde, Scientific Electronic Library Online, Cochrane Library, Catálogo de Teses e Dissertações da Capes e Google Acadêmico. O resultado do fluxo de seleção, desta etapa metodológica, será apresentado em forma de figura, conforme o Preferred Reporting Items for Systematic Reviews and Meta-Analyses. 

Resultados: O mapeamento dos dados permitirá o agrupamento dos cuidados além de evidenciar a necessidade destes para os recém-nascidos submetidos à fototerapia.

Conclusão: Espera-se salientar a indispensabilidade dos cuidados de enfermagem a este público e reforçar a necessidade de educação continuada aos profissionais.
Relação entre tempo de cuidado e necessidades de familiares cuidadores de idoso em cuidados paliativos.
Authors: Santos  Jacilene Santiago do Nascimento Trindade dos , Alves Manuela Bastos , Baptista Simone Conceição Oliveira , Andrade Magna Dos Santos , Silva Richardson Augusto Rosendo da , Silva Rudval Souza da
Published: September 2022

Objetivo: verificar a relação entre o fator tempo dispensado na prestação dos cuidados e as principais necessidades do familiar cuidador de pessoas idosas hospitalizadas e em cuidados paliativos.

Método: estudo descritivo de corte transversal e abordagem quantitativa, realizado com 205 familiares cuidadores de pessoas idosas em cuidados paliativos num hospital de grande porte de uma capital do Nordeste brasileiro. A coleta de dados ocorreu entre os meses de agosto e outubro de 2019 utilizando-se de um questionário validado que contemplou dados sociodemográficos, o tempo de cuidados e 21 perguntas relacionadas as necessidades humanas básicas. Foi usado o teste qui quadrado para verificar a relação entre os aspectos de cada uma das dimensões (física, emocional, social e espiritual) e o tempo de cuidado considerando-se como estatisticamente significante um p-valor ≤ 0,05.

Resultados: Os cuidadores familiares apresentaram elevados percentuais de necessidades relacionadas ao controle emocional, resolução de conflitos consigo mesmo, dificuldade em sair de casa, fazer planos e poder realizá-los e suprimir suas demandas econômico-financeiras associadas ao maior tempo gasto no acompanhamento do ente querido.

Conclusões: os resultados deste estudo fornecem um perfil das principais necessidades do familiar cuidador, ficando evidente que esse cuidador necessita de suporte, por parte da equipe de saúde, no sentido de desenvolver estratégias para seu controle emocional, minimizar os conflitos consigo próprio, rever suas demandas pessoais e manter a rotina de atividades de lazer, além de sentir-se bem para realizar planos futuros.
Associação entre qualidade de vida e consumo de substâncias psicoativas entre estudantes de grupos de ancestralidade do continente africano.
Authors: Damasceno Rudson Oliveira , Alves Jeorgia Pereira , Casotti Cezar Augusto , Boery Eduardo Nagib , Rosa Randson Souza , Boery Rita Narriman Silva de Oliveira
Published: September 2022

Objetivo: analisar a associação entre Qualidade de Vida e consumo de substâncias psicoativas em alunos de ancestralidade do continente africano.

Método: pesquisa epidemiológica, descritiva, comparativa e de delineamento transversal, realizada entre os meses de agosto e novembro de 2017, com adolescentes matriculados em uma escola afro-brasileira localizada na região nordeste. O procedimento amostral adotado foi o aleatório simples. Para a coleta de dados, foi utilizado formulário sociodemográfico; um inquérito sobre Qualidade de Vida (WHOQOL-bref) e outro sobre consumo de substâncias psicoativas (DUSI - Drug Use Screening Inventory). O teste U de Mann-Whitney não paramétrico foi usado para comparar os grupos.

Resultados: a mostra foi composta por 203 escolares, destes, 123 (60,3%) eram do sexo feminino, 108 (53,2%) estavam na faixa etária de 16 a 19 anos e 157 declaravam-se negros (77,3%). Já para o uso de drogas, 101 (49,8%) adolescentes relataram usar ao menos uma droga lícita ou ilegal. O álcool foi a droga mais usada, total de 88 estudantes. Os adolescentes que relatam uso de substâncias psicoativas no último mês apresentaram menor escore de Qualidade de Vida em nossos domínios físico (p<0,05), psicológico (p<0,05) e ambiental (p<0,05).

Conclusão: o consumo de substâncias lícitas e ilícitas mostrou-se como um ponto de grande importância para a qualidade de vida dos adolescentes de ancestralidade do continente africano e para a percepção de aspectos relacionados ao contexto que estão inseridos.
Análisis de datos acelerográficos de Costa Rica para la generación de modelos de atenuación: periodo 1998 a 2021
Authors: Schmidt-Díaz Víctor , Esquivel-Salas Luis C.
Published: September 2022

Los modelos de atenuación de las ondas sísmicas se obtienen a partir de datos aceleográficos y representan uno de los insumos más importantes para los estudios de amenaza sísmica, la cual es fundamental para el diseño de estructuras y sistemas sismorresistentes cada vez más eficientes. En vista de que el registro de nuevos sismos aporta información sumamente valiosa para actualizar dichos modelos y estudios, es necesario que ambos se revisen y se replanteen con cierta periodicidad. En este trabajo se desarrolla un análisis descriptivo de datos acelerográficos registrados en estaciones de Costa Rica hasta el año 2021, como base para el posterior desarrollo de modelos de atenuación para el país. La investigación está motivada por el gran número de datos acelerográficos registrados en los últimos 11 años, gracias a la densificación de la red de instrumentos que administra el Laboratorio de Ingeniería Sísmica de la Universidad de Costa Rica. Esto hace que, en el momento actual, se disponga de una base de datos acelerográficos suficientemente amplia y robusta, para poder generar ecuaciones de predicción del movimiento fuerte, conocidas como GMPEs (del inglés Ground motion prediction equations) que representen la atenuación en los tres regímenes tectónicos presentes en el país: cortical, subducción interfase y subducción intraplaca. En esta etapa de la investigación se analizan un total de 3192 registros asociados a 245 sismos, obtenidos después de aplicar una serie de filtros de selección sobre una base de datos compuesta inicialmente por 3981 registros. El análisis ha consistido en obtener las distribuciones del número de eventos y del número de registros en función de la magnitud, profundidad, régimen tectónico y tipo de suelo en la estación de registro, clasificando éste siguiendo los criterios del Código Sísmico de Costa Rica (CFIA, 2010). Entre los principales resultados de esta investigación, que condicionarán los rangos de aplicabilidad de los modelos que se desarrollen posteriormente, se destacan (1) la identificación de una escasez de registros en condiciones de suelo duro o roca (S1), así como de magnitudes altas a distancias hipocentrales cortas y de magnitudes bajas a distancias largas.; (2) el rango de distancias hipocentrales de los registros disponibles es (5-300 km) para sismos corticales, (15-300 km) para subducción interfase y (40-400 km) para subducción intraplaca. Finalmente, se estimaron dos medidas de distancia para fuentes extendidas, denominadas de ruptura, R RUP, y de Joyner y Boore, R J&B, empleadas cuando la ruptura no puede considerarse como puntual. Dichas distancias se han calculado a partir de las distancias para fuentes puntuales, epicentral e hipocentral, R EPI e R HYPO respectivamente, siguiendo la metodología propuesta por Thompson y Worden (2018).
Crop-land suitability analysis using geographic information system and remote sensing
Authors: Ramu Penki , Sai Santosh B. , Chalapathi K.
Published: September 2022

Food, water, and energy scarcity threaten India's future, and they must be addressed first. To meet the country's ever-increasing population needs, agricultural productivity must be expanded. For the crop-land suitability, we have studied an area of about 6,539 km2 in Vizianagaram district. The majority of the land is used for paddy agriculture (Kharif). The crop-land suitability has been evaluated based on the different parameters identified in that study area. “Remote sensing (RS)” and “geographic information system (GIS)” were combined for the crop-land suitability using nine parameters. The slope, elevation, rainfall, soil texture, lithology, groundwater, land use–land cover (LULC), TWI, and land surface temperature are the primary criteria used to determine the crop-land suitability in the Vizianagaram district (AP). Thematic maps were created using Landsat 8 images and SRTM DEM images from USGS Earth Explorer. Based on these maps and the influence of these parameters, we may assign weights to the parameters and then rank them, the Analytic Hierarchy Process (AHP) allowing us to identify which area is more suitable for good crop productivity and which is not. In this study, the soils are divided into four categories: low suitability, moderate suitability, high suitability, and extremely high suitability. The suitability index is found to be in the range of 0–55.2%, which indicates the lack of outstanding agricultural lands in the sudy region.
Mometasone furoate nasal spray in Italian children with seasonal allergic rhinitis: a comprehensive assessment
Authors: Indolfi Cristiana , Dinardo Giulio , Rosaria Umano Giuseppina , Klain Angela , Contieri Marcella , Decimo Alberto , Decimo Fabio , Ciprandi Giorgio , Del Giudice Michele Miraglia
Published: September 2022

Objective: Seasonal allergic rhinitis (SAR) is a common disease of childhood and is characterized by type 2 inflammation, bothersome symptoms, and impaired quality of life (QoL). Intranasal corticosteroids are effective medications in managing SAR. In addition, mometasone furoate nasal spray (MFNS) is a well-known therapeutic option. However, the literature provided no data about the effects of MFNS in European children with SAR. Thus, this study addressed this unmet requirement.
Methods: MFNS was compared to isotonic saline. Both treatments were prescribed: one drop of spray per nostril, twice a day, for 3 weeks. Nasal cytology, total symptom score (TSS), visual analogic scale concerning the parental perception of severity of symptoms, and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline, after 7 and 21 days, and 1 month after discontinuation.
Results: MFNS significantly reduced eosinophil and mast cell counts, improved QoL, and relieved symptoms, as assessed by doctors and perceived by parents. These effects persisted over time, even after discontinuation. Both treatments were safe and well-tolerated.
Conclusions: The present study documented that a 3-week MFNS treatment was able to significantly dampen type 2 inflammation, improve QoL, and reduce severity of symptoms in Italian children with SAR, and was safe.
The Adverse Cardiovascular Effects of Bruton Tyrosine Kinase Inhibitors on the Mouse Model
Authors: Patel Dev
Published: September 2022

Bruton Tyrosine Kinase (BTK) inhibitors have revolutionized the treatment of several hematologic malignancies. However, treatment of cancers such as Chronic Lymphocytic Leukemia (CLL) with BTK inhibitors has led to many adverse cardiovascular side effects. These side effects include atrial fibrillation (AF), myocardial fibrosis, and left atrial enlargement. In this study, a mouse model was used in order to see if the cardiovascular side effects caused by BTK inhibitors resolved upon discontinuation of treatment. Echocardiograms, electrophysiology studies, and histology analyses were utilized in order to determine if these side effects were resolved. Our results showed that while there was a decrease in the adverse cardiovascular effects after recovery there was still a significant difference in phenotypes between the control and experimental groups.
The Mystery of Evil and the Hiddenness of God: Understanding Mystery in Christian Theodicy
Authors: Liu Sophia
Published: September 2022

Mysterium iniquitatis, the “mystery of evil,” constitutes the unresolved theological, philosophical, and pastoral debates over the pervasion of evil and suffering that contradicts a world under the providence of the omnipotent, omniscient, and benevolent God of Christianity. At the same time, the idea of mystery not only characterizes the conundrum of evil but also the hiddenness of God that formulates the relationship between creature, creator, and the pervasion of suffering that spans Christian scriptural and theological thought. The paper aims to construct a comparative exegesis of three works concerned with the meaning and significance of mystery in Christian theodical thought. Explicating the Grand Inquisitor from Fyodor Dostoevsky’s The Brothers Karamazov, the paper begins with highlighting a cynical view of mystery as a tool for the authority of liturgical institutions that ultimately offers no pastoral consolation within the framework of Christian theology. Then, drawing on Karen Kilby’s critique of Post-Enlightenment theodicy and its shortcoming in understanding the creator and the divine and Gustav Gutiérrez’s idea of divine love and gratuitousness, I propose understanding mystery as a destabilizing opening in the practice of theodicy that constellates ways to engage theologically with the mystery of the divine and translating it into an ethical understanding of, instead of a justification for, the pervasion of evil and injustice.
Management of Patients with Thyroid-Associated Ophthalmopathy: Role of Spectral Domain Optical Coherence Tomography
Authors: DAGDELEN Kenan , MUZ Ömer Ersin
Published: September 2022

AIM: To demonstrate the changes in optic nerve head (ONH), retinal nerve fiber layer (RNFL) and macula in patients with thyroid-associated ophthalmopathy (TAO) by spectral domain optical coherence tomography (SD-OCT).

METHODS: We included forty-one eyes of 41 patients with a diagnosis of TAO and forty-eight eyes of 48 age- and sex-matched healthy subjects (control group) from June 2016 to July 2018. The ONH parameters, RNFL and macular thicknesses in the nine macular quadrants according to ETDRS were measured with SD-OCT. Proptosis level was determined by Hertel exophthalmometer. Clinical activity score (CAS) according to the European Group of Graves' Orbitopathy (EUGOGO) guidelines was determined in all patients.

RESULTS: Superior, inferior and average RNFL thicknesses were significantly lower in the TAO group compared to the control group (p < 0.05). Optic disc area was significantly larger in the TAO group. Outer quadrant macular thicknesses and average macular thickness were significantly lower in the TAO group (p < 0.05). CAS had a weak correlation with RNFL thickness and average macular thickness.

CONCLUSION: Alterations in RNFL thicknesses and macular thicknesses according to ETDRS template can be detected before the development of ocular symptoms in patients with TAO. OCT is a convenient, non-invasive tool for the evaluation and follow-up of macular structural changes. Patients can be diagnosed at an early stage prior to the development of functional damage. However, the low number of studies investigating this subject and the conflicting findings of existing studies necessitate further studies.
Metodologias ativas de aprendizagem utilizando modelo didático como ferramenta educacional para estudar interações moleculares em membranas e matriz extracelular
Authors: Da Matta Luciana Duarte Martins , Ferreira Veronica Danielle Santos , Lima Rayana Vanessa da Costa , Medeiros Mateus Vinícius dos Santos , Silva do Nascimento Jéssika Karoline , Filgueira Luciana Guimarães Alves , Souza Giulianna Paiva Viana de Andrade
Published: September 2022

Os assuntos membrana e matriz extracelular são de difícil compreensão por parte dos alunos, assim, o objetivo deste trabalho foi estimular os alunos a confeccionar as moléculas constituintes da membrana e da matriz extracelular e a montar um modelo didático a partir delas. A metodologia proposta consistiu em separar a turma em grupos em que, cada grupo, seria responsável pela confecção e exposição para a sala das moléculas (Lipídeos de membrana, integrinas, fibronectina, colágeno, elastina, laminina, ácido hialurônico e proteoglicanos). As moléculas foram apresentadas à turma e os grupos, juntos, montaram a membrana e a matriz apontando a localização das moléculas e suas possíveis interações. Todos os grupos criaram suas moléculas de acordo com as especificações dadas e interagiram positivamente durante a montagem do modelo didático. Consideramos que a atividade atingiu seus objetivos pela construção de um modelo didático facilmente utilizável para a compreensão de tais assuntos.
Criação de animações stop motion como estratégia para o estudo do transporte de substâncias através da membrana celular no ensino médio
Authors: De Melo Camila Coelho , Morelli Karina Alessandra
Published: September 2022

O ensino de biologia celular, como o conteúdo de transporte de substâncias através da membrana celular, apresenta complexidade devido à sua natureza microscópica, o que exige um grau elevado de abstração por parte dos estudantes do Ensino Médio. Assim, é importante que novas abordagens e metodologias que auxiliem a visualização e a compreensão destes temas abstratos sejam incorporadas. As tecnologias digitais de informação e comunicação (TDIC), como animações stop motion, instrumentalizam o ensino lúdico, contribuindo para a aprendizagem, além de permitir a formação de um ambiente propício à discussão de vários temas científicos. Diante disso, o presente trabalho teve por objetivo produzir uma Sequência Didática com estudantes do Ensino Médio de uma escola estadual do município de Santo Antônio de Pádua/RJ, abordando propriedades e a importância da membrana celular e seus mecanismos de transporte por meio de animações stop motion. Os próprios estudantes construíram moldes simbolizando a membrana, fotografaram e editaram os vídeos, criando a ilusão de movimento, o que facilitou a aprendizagem desses processos biológicos. A atividade auxiliou os estudantes na compreensão do conteúdo, além de gerar maior interesse, entusiasmo durante as aulas e engajamento entre os mesmos, evidenciando a importância da utilização das TDICs, principalmente em assuntos considerados abstratos.
Development and use of puzzle and board games to complement the learning of biochemistry at university
Authors: Soares Caio Correia de Almeida , Araújo Márjory Lima Holanda
Published: September 2022

Biochemistry is an important area of knowledge for biology-based courses, although constantly the students face difficulties regarding the integral comprehension of issues involving biomolecules and metabolism. This scenario comprises an opportunity to adopt active methodologies such as playful classes. Thereby, this work aims to develop and apply a puzzle and a board game of Questions and Answers about biochemistry. These games were based on biomolecules and metabolism contents and were designed to offer a robust number of interactions possible between players to game and players to players. The games were named Bioquease Biomoléculas and Bioquease Metabolismo. They were applied to two classes of biochemistry (n=29), in which the students filled out survey forms to evaluate the games. The results showed that the questions of the game were related to what was learned in class, the difficulty was coherent with the one from the classes, the dynamics of the games were easy to comprehend, and the knowledge obtained was satisfactory, which comprise good alternatives to complement biochemistry classes.
As verticalidades e horizontalidades no Território do Rádio no Vale do Taquari/RS
Authors: Brandt Grazielle Betina , Fedrizzi Diogo Daroit , Felippi Ângela Cristina Trevisan
Published: September 2022

Nesse artigo trazemos o rádio para o centro do debate sobre a temática que aproxima a comunicação e o desenvolvimento regional. Encontramos nos conceitos de verticalidades e horizontalidades de Milton Santos a abordagem teórico-analítica para realizar esse estudo. O objetivo é identificar as verticalidades e horizontalidades que se concretizam no território usado do rádio no Vale do Taquari, no Rio Grande do Sul, especificamente, no processo de distribuição espacial das emissoras comerciais com outorga nessa região. No campo teórico-metodológico, os conceitos de território usado, as verticalidades e horizontalidades dialogam com os estudos da Economia Política da Comunicação (EPC), tendo respaldo ainda na Geografia da Comunicação. A pesquisa se caracteriza pela sua abordagem qualitativa. A partir das análises verifica-se que os vetores de verticalidades se sobressaem na ocupação espacial do território do rádio no Vale do Taquari, inicialmente, a partir da ação de forças exógenas e, num segundo momento, com movimentações dentro do próprio território, ocasionando a formação de redes e a concentração de propriedade.
Entre modernização e obsolescência: a trajetória da Companhia Telefônica Catarinense (1927-1969)
Authors: Goularti Filho Alcides
Published: September 2022

O objetivo desse artigo é analisar a trajetória da Companhia Telefônica Catarinense (CTC) dentro da formação econômica de Santa Catarina no processo de integração do sistema nacional de telecomunicações. A trajetória da CTC será analisada combinando dois movimentos: a modernização e a obsolescência da sua capacidade de expansão comercial e produtiva, que envolve desde a fundação da empresa, em 1927, até sua estatização, em 1969. Para analisar esse período dividimos a trajetória da CTC em quatro momentos: a) modernização extensiva e contínua (1927-1943); b) obsolescência forçada e temporária (1943-1947); c) modernização intensiva e limitada (1947-1961); e d) obsolescência irreversível e insolvência financeira (1961-1969). O texto está dividido em três tópicos. Iniciamos com uma introdução que aborda as comunicações em Santa Catarina e define as categorias de análise. Em seguida, o tópico formação, expansão e estatização da CTC apresenta os momentos de modernização e obsolescência. Por fim, temos as considerações finais que sintetiza o movimento geral da estatização da telefonia em Santa Catarina.
[Un]performing voice: Simnikiwe Buhlungu/Euridice Zaituna Kala
Authors: Gentric Katja
Published: September 2022

Two unspectacular interventions, performed in central Johannesburg by Simnikiwe Buhlungu and Euridice Zaituna Kala, evidence the performativity of voice in public space. Addressing the unheard in contemporary society, they operate a shift in the way language is put to use (Cassin 2018). In paradoxical reciprocity, the action of [un]hearing comes to signify a fine-tuned form of informed and involved listening capable of bringing to the fore that which ordinarily goes by unheard or remains stifled. An "accented" way of speaking for example is inflected, shows situatedness, indicates individuated thought patterns (Coetzee 2013). This form of speech carries the legacy of historical exchange between languages and the power relations involved. It bears recognition of the multiple languages involved in the totality of any act of speech. Given current global concerns, it seems indispensable to caution that language identity cuts two ways: it is simultaneously a marker of belonging and a means of singling out those who do not belong. Side-stepping identity-politics, protesting discriminations based on language proficiency, the two interventions suggest self-transforming labour where the reader or listener may potentially perform an activist interruption of the [un]heard.
The Proficiency and Opinions of the Pre-service Primary Teachers in Performing Hands-on Science Experiments
Authors: AKTAŞ İdris
Published: September 2022

It is a challenge to carry out science lessons with experiments both in the conditions that emerged with the COVID-19 pandemic and in schools where there is a shortage of laboratories and materials. This study aims to examine the proficiency and opinions of pre-service primary teachers (PPTs) pertaining to performing hands-on science experiments with simple tools. This case study was carried out with 47 PPTs selected according to the convenient sampling method. Data sources included video recordings of the experiments performed by the PPTs over ten weeks and an open-ended questionnaire. The videos were analyzed with the analytical rubric and presented with descriptive statistics. The open-ended questions were analyzed with content analysis. Results showed that PPTs are sufficient for choosing suitable simple tools for experiments and for applying the experiments gradually, extensively, and correctly, while they need to develop in explaining the concepts and information correctly. In addition, the majority of the PPTs stated that they did not have any difficulties whilst performing the experiments, they could perform science experiments with simple tools, the experiments would reflect positively on the learning outcomes of the students, and they could conduct science lessons with experiments using simple tools and alternative materials, even if there is no laboratory in the school. Future studies should focus on increasing the proficiency of PPTs to give scientific explanations for experiments.
Среднее профессиональное образование в России: ресурс для развития экономики и формирования человеческого капитала
Authors: Дудырев Федор , Анисимова Ксения , Артемьев Игорь , Бондаренко Наталья , Мальцева Вера , Крайчинская Светлана , Рожкова Ксения , Романова Ольга , Травкин Павел , Шабалин Алексей , Шугаль Николай
Published: September 2022

В докладе представлен обзор текущего состояния и трендов развития среднего профессионального образования в России. Динамика спроса на СПО, карьерные перспективы выпускников колледжей и их заработная плата, распространение демонстрационного экзамена, совершенствование инфраструктуры, использование «цифровых» инструментов в условиях противодействия COVID-19 анализируются на основе широкого круга источников: результатов Мониторинга экономики образования НИУ ВШЭ, Мониторинга качества подготовки кадров, данных образовательной статистики и др. Приоритетные направления развития системы СПО, реализуемые в рамках национального проекта «Образование», рассматриваются в контексте выполнения Указа Президента Российской Федерации от 21 июля 2020 г. No 474 «О национальных целях развития Российской Федерации на период до 2030 года».