bluuebunny/crossref_metadata_2025 huggingface dataset:
GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes
Authors: del Olmo-Garcia María Isabel , Merino-Torres Juan Francisco
Published: April 2018

Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting treatment. Among all the drugs available, the compounds known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) appear to be not just innocuous in terms of CVD but indeed to be beneficial. GLP-1 RA actions not only translate on an improvement of well-known cardiovascular risk factors such as glycaemic control, dyslipidaemia, weight, or arterial hypertension but also might show benefits on endothelial function, coronary ischaemia, and heart failure. On the other hand, recent clinical trials aimed at studying cardiovascular episodes have been conducted with GLP-1 RAs. Only liraglutide and semaglutide have shown superiority in cardiovascular benefit compared with placebo. Although many of the mechanisms by which liraglutide and semaglutide produce a cardiovascular benefit are still unknown it would be desirable for these benefits to be incorporated into the therapeutic algorithms routinely used in clinical practice. The purpose of this review is to explore GLP-1 RA actions not only in cardiovascular risk factors (glucose, weight, and hypertension) but also the possible effects on established cardiovascular disease.
Good Manufacturing Practices and Microbial Contamination Sources in Orange Fleshed Sweet Potato Puree Processing Plant in Kenya
Authors: Malavi Derick Nyabera , Muzhingi Tawanda , Abong’ George Ooko
Published: April 2018

Limited information exists on the status of hygiene and probable sources of microbial contamination in Orange Fleshed Sweet Potato (OFSP) puree processing. The current study is aimed at determining the level of compliance to Good Manufacturing Practices (GMPs), hygiene, and microbial quality in OFSP puree processing plant in Kenya. Intensive observation and interviews using a structured GMPs checklist, environmental sampling, and microbial analysis by standard microbiological methods were used in data collection. The results indicated low level of compliance to GMPs with an overall compliance score of 58%. Microbial counts on food equipment surfaces, installations, and personnel hands and in packaged OFSP puree were above the recommended microbial safety and quality legal limits. Steaming significantly (P<0.05) reduced microbial load in OFSP cooked roots but the counts significantly (P<0.05) increased in the puree due to postprocessing contamination. Total counts, yeasts and molds, Enterobacteriaceae, total coliforms, andE. coliandS. aureuscounts in OFSP puree were 8.0, 4.0, 6.6, 5.8, 4.8, and 5.9 log10cfu/g, respectively. In conclusion, equipment surfaces, personnel hands, and processing water were major sources of contamination in OFSP puree processing and handling. Plant hygiene inspection, environmental monitoring, and food safety trainings are recommended to improve hygiene, microbial quality, and safety of OFSP puree.
Dental Student Skills in Matching Radiographs for Forensic Identification and in Forensic Knowledge
Authors: Sivaneri Mona , Wiener R. Constance , Shockey Alcinda K. Trickett , Waters Christopher
Published: April 2018

Purpose and Objectives. Dental and dental hygiene curricula must meet the core competencies established by the American Dental Association Commission on Dental Accreditation. As a result, there is limited time to expose students to the research and knowledge associated with additional important topics, such as dental forensics. The purpose of this research is to assess dental forensic knowledge and dental forensic radiographic skills of dental students. Methods. Ten radiographs of extracted permanent maxillary molars were exposed. One of the teeth was heat-altered to 600°F (315.6°C) for 15 minutes and then was radiographed. The 11 radiographs were presented to 152 dental students who were asked to match the radiograph of the heat-altered tooth to the original radiograph of that tooth. Students were also asked to respond to a 10-question survey about dental forensic knowledge. Results. Most (92.1%) students matched the heat-altered tooth’s radiograph with the original radiograph. Five survey questions had at least 70% of the respondents with correct responses. There were no statistically significant differences by dental class status or sex. Conclusion. Although dental students were competent in matching radiographs, there remains a need for more knowledge about dental forensics.
Damage Features of Altered Rock Subjected to Drying‐Wetting Cycles
Authors: Qin Zhe , Chen Xuxin , Fu Houli
Published: April 2018

An abandoned open pit was used as a tailing pond for a concentrating mill, with the height of the water surface subject to cyclic fluctuation. The effects of drying and wetting cycles on the mechanical parameters of pit rock were tested. Interactions of the hydrochemical environment, due to the dissolution of tailings, and drying and wetting cycles caused degradation of mechanical properties in the rock. It was found that uniaxial compressive strength and elastic modulus decreased as the number of dry/wet cycles increased. The quantitative relationship between the mechanical parameters and the number of dry/wet cycles was indicated by an exponential function. In addition to uniaxial testing, cohesion and the internal friction angle were determined through triaxial testing. The shear strength index deteriorated under the drying and wetting cycles. The hydrochemical environment also negatively affected the mechanical parameters. Potential effects between drying and wetting cycles and slope displacement were analyzed by on‐site monitoring. The results show that the displacement increased because of the drying and wetting cycles, which may lead to sudden failure of the slope.
Data-Driven Modeling of a Commercial Photovoltaic Microinverter
Authors: Abbood Hayder D. , Benigni Andrea
Published: April 2018

We present a data-driven modeling (DDM) approach for static modeling of commercial photovoltaic (PV) microinverters. The proposed modeling approach handles all possible microinverter operating modes, including burst mode. No prior knowledge of internal components, structure, and control algorithm is assumed in developing the model. The approach is based on Artificial Neural Network (ANN) and Fast Fourier Transform (FFT). To generate the data used to train the model, a Power Hardware in the Loop (PHIL) approach is applied. Instantaneous inputs-outputs data are collected from the terminals of a commercial PV microinverter at time domain. Then, the collected data are converted to the frequency domain using Fast Fourier Transform (FFT). The ANNs that are the core of the DDM are developed in frequency domain. The outputs of the ANNs are then converted back to time domain for validation and use in system level simulation. The comparison between measured and simulated data validates the performance of the presented approach.
Ultrasound-Guided Intervention for Treatment of Trigeminal Neuralgia: An Updated Review of Anatomy and Techniques
Authors: Allam Abdallah El-Sayed , Khalil Adham Aboul Fotouh , Eltawab Basma Aly , Wu Wei-Ting , Chang Ke-Vin
Published: April 2018

Orofacial myofascial pain is prevalent and most often results from entrapment of branches of the trigeminal nerves. It is challenging to inject branches of the trigeminal nerve, a large portion of which are shielded by the facial bones. Bony landmarks of the cranium serve as important guides for palpation-guided injections and can be delineated using ultrasound. Ultrasound also provides real-time images of the adjacent muscles and accompanying arteries and can be used to guide the needle to the target region. Most importantly, ultrasound guidance significantly reduces the risk of collateral injury to vital neurovascular structures. In this review, we aimed to summarize the regional anatomy and ultrasound-guided injection techniques for the trigeminal nerve and its branches, including the supraorbital, infraorbital, mental, auriculotemporal, maxillary, and mandibular nerves.
Effects of Number of Repetitions and Number of Hours of Shaping Practice during Constraint-Induced Movement Therapy: A Randomized Controlled Trial
Authors: Abdullahi Auwal
Published: April 2018

Background. Constraint-induced movement therapy (CIMT) is effective in improving motor outcomes after stroke. However, its existing protocols are resource-intensive and difficult to implement. The aim of this study is to design an easier CIMT protocol using number of repetitions of shaping practice.Method. The study design was randomized controlled trial. Participants within 4 weeks after stroke were recruited at Murtala Muhammad Specialist Hospital. They were randomly assigned to groups A, B, C, and D. Group A received 3 hours of traditional therapy. Groups B, C, and D received modified CIMT consisting of 3 hours of shaping practice per session, 300 repetitions of shaping practice in 3 sessions, and 600 repetitions of shaping practice in 3 sessions per day, respectively, and constraint for 90% of the waking hours. All treatment protocols were administered 5 times per week for 4 weeks. The primary outcome was measured using upper limb Fugl-Meyer assessment, while the secondary outcome was measured using motor activity log, Wolf Motor Function Test, and upper limb self-efficacy test at baseline, 2 weeks, and 4 weeks after intervention.Result. There were 48 participants 4 weeks after intervention. The result showed that there was no significant difference between groups at baseline(p>0.05). Within-group improvements attained minimal clinically important difference (MCID) in modified CIMT and 300 repetitions and 600 repetitions groups.Conclusion. Number of repetitions of shaping practice significantly improved motor function, real-world arm use, and upper limb self-efficacy after stroke. Therefore, it seems to be a simple alternative for the use of number of hours.Trial Registration. This trial is registered with Pan African Clinical Trial Registry (registration number:PACTR201610001828172) (date of registration: 21/10/2016).
Application of DICM on Similar Material Simulation Experiment for Rock‐Like Materials
Authors: Kong Hailing , Wang Luzhen , Gu Guoqing , Xu Bing
Published: April 2018

The digital image correlation method (DICM) has been applied to similar material simulation experiments for rock‐like materials, to overcome the weakness of traditional measurements, for example, data discontinuous. In this paper, the movement and fracturing process of the overlying strata during excavation are observed and studied, and the distributions of stress, strain, and deformation in the overlying strata are obtained based on similar material simulation. The DICM is applied to improve the testing method and to optimize the discontinuity of testing points; of course, the difference of rock deformation in the overlying strata during excavation is considered. Full‐field deformation and strain are analyzed by the DICM. To verify the accuracy of the DICM, results obtained from the DICM, numerical simulation and similar material simulation, are compared. The DICM can reflect the characteristics of locality and randomness of rock‐like materials more real than numerical simulation, and comparing with similar material simulation, it can directly reproduce the movement and fracturing process of the overlying strata during full‐field excavation. It shows that, the DICM is entirely feasible to using in the large scale full‐field deformation measurement on complex rock structure, and it is of theoretical importance for testing for rock‐like materials.
Analysis of Electromagnetic Propagation from MHz to THz with a Memory-Optimised CPML-FDTD Algorithm
Authors: Rodríguez-Sánchez A. , Couder-Castañeda C. , Hernández-Gómez J. J. , Medina I. , Peña-Ruiz S. , Sosa-Pedroza J. , Enciso-Aguilar M. A.
Published: April 2018

FDTD method opened a fertile research area on the numerical analysis of electromagnetic phenomena under a wide range of media and propagation conditions, providing an extensive analysis of electromagnetic behaviour like propagation, reflection, refraction, and multitrajectory phenomena. In this paper, we present an optimised FDTD-CPML algorithm, focused in saving memory while increasing the performance of the algorithm. We particularly implement FDTD-CPML method at high frequency bands, used in several telecommunications applications as well as in nanoelectromagnetism. We show an analysis of the performance of the algorithm in single and double precision, as well as a stability of the algorithm analysis, from where we conclude that the implemented CPML ABC constitutes a robust choice in terms of precision and accuracy for the high frequencies herein considered. It is important to recall that the CPML ABC parameters provided in this paper are fixed for the tested range of frequencies, that is, from MHz to THz.
An Intervention Target for Myocardial Fibrosis: Autophagy
Authors: Lu Chunmiao , Yang Yusong , Zhu Yaping , Lv Shichao , Zhang Junping
Published: April 2018

Myocardial fibrosis (MF) is the result of metabolic imbalance of collagen synthesis and metabolism, which is widespread in various cardiovascular diseases. Autophagy is a lysosomal degradation pathway which is highly conserved. In recent years, research on autophagy has been increasing and the researchers have also become cumulatively aware of the specified association between autophagy and MF. This review highlights the role of autophagy in MF and the potential effects through the administration of medicine.
In Situ Miniaturised Solid Phase Extraction (m-SPE) for Organic Pollutants in Seawater Samples
Authors: Abaroa-Pérez B. , Sánchez-Almeida G. , Hernández-Brito J. J. , Vega-Moreno D.
Published: April 2018

Solid phase extraction (SPE) is a consolidated technique for determining pollutants in seawater samples. The current tendency is to miniaturise systems that extract and determine pollutants in the environment, reducing the use of organic solvents, while maintaining the quality in the extraction and preconcentration. On the other hand, there is a need to develop new extraction systems that can be fitted to in situ continual monitoring buoys, especially for the marine environment. This work has developed a first model of a low-pressure micro-SPE (m-SPE) for persistent organic pollutants (POPs) that can be simply applied to in situ monitoring in the marine environment. This system reduces the volumes of sample and solvents required in the laboratory in comparison with conventional SPE. In the future, it could be used in automated or robotic systems in marine technologies such as marine gliders and oceanographic buoys. This system has been optimised and validated to determine polycyclic aromatic hydrocarbons (PAH) in seawater samples, but it could also be applied to other kinds of persistent organic pollutants (POPs) and emerging pollutants.
Detection of HER2 through Antibody Immobilization Is Influenced by the Properties of the Magnetite Nanoparticle Coating
Authors: Villegas-Serralta Enrique , Zavala Oscar , Flores-Urquizo Israel Alejandro , García-Casillas Perla E. , Chapa González Christian
Published: April 2018

Considerable effort has been focused on improving the control of size, shape, and surface modifications to detect proteins. The purpose of this study was to compare the efficiencies of aminosilane-coated magnetite (As-M) nanoparticles (NPs), dextran-coated magnetite nanoparticles (Dx-M), and bare nanoparticles for conjugating single-chain variable fragment antibodies (scFvs) with the aim of detecting the human epidermal growth factor receptor 2 (HER2) protein. Dx-M and As-M NPs were characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, and Raman spectroscopy. Dx-M and As-M were conjugated with a monoclonal scFv for active targeting of the HER2 antigen. Aminosilane surface coating enhanced the scFv conjugation efficiency over twofold compared to that of the dextran-coated magnetite NPs for the detection of HER2 proteins.
Regulatory T Lymphocytes in Periodontitis: A Translational View
Authors: Alvarez Carla , Rojas Carolina , Rojas Leticia , Cafferata Emilio A. , Monasterio Gustavo , Vernal Rolando
Published: April 2018

Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy. In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the ex vivo and in vivo manipulation of the Treg compartment. Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies. Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.
Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
Authors: Chu Fengna , Shi Mingchao , Lang Yue , Shen Donghui , Jin Tao , Zhu Jie , Cui Li
Published: April 2018

The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). The etiology of MS is not clear, and it should involve both genetic and extrinsic factors. The extrinsic factors responsible for predisposition to MS remain elusive. Recent studies on MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have found that gastrointestinal microbiota may play an important role in the pathogenesis of MS/EAE. Thus, gut microbiome adjustment may be a future direction of treatment in MS. In this review, we discuss the characteristics of the gut microbiota, the connection between the brain and the gut, and the changes in gut microbiota in MS/EAE, and we explore the possibility of applying microbiota therapies in patients with MS.
Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis
Authors: Fondjo Linda Ahenkorah , Sakyi Samuel Asamoah , Owiredu William K. B. A. , Laing Edwin Ferguson , Owiredu Eddie-Williams , Awusi Ebenezer Kwesi , Ephraim Richard K. D. , Kantanka Osei Sarfo
Published: April 2018

Background. Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status. Oestrogen decline during menopausal stages promotes hypovitaminosis D. However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked. This study assessed vitamin D status among pre- and postmenopausal T2DM women and determined its association with glycemic control and influence of lifestyle habits on hypovitaminosis D.Methods. This cross-sectional study was conducted at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Structured questionnaires were administered to 192 T2DM women; blood samples were collected for estimation of 25(OH) D and insulin using ELISA. Fasting blood glucose (FBG), lipid profile, glycated haemoglobin (HbA1c), and calcium were measured. Statistical analyses were performed using Graphpad Prism 6.Results. The prevalence of vitamin D inadequacy was 92.2%. Hypovitaminosis D was more prevalent among the postmenopausal T2DM women (63.8% versus 58.2%). Hypovitaminosis D significantly associated with insulin [R2=0.01760,p=0.0008], HbA1c [R2=0.3709,p=<0.0001], and FBG [R2=0.3465,p=0.0001] in only the postmenopausal women.Conclusion. Vitamin D deficiency is prevalent in pre- and postmenopausal T2DM but higher among postmenopausal women. Adequate vitamin D levels in both groups were associated with improved glucose control while hypovitaminosis D in the postmenopausal women was related to poorer glucose control. Vitamin D screening should be incorporated into management plan for T2DM to serve as an early tool for prevention of vitamin D deficiency.
Optimal Payments to Connected Depositors in Turbulent Times: A Markov Chain Approach
Authors: Csercsik Dávid , Kiss Hubert János
Published: April 2018

We propose a discrete time probabilistic model of depositor behavior which takes into account the information flow among depositors. In each time period each depositors’ current state is determined in a stochastic way, based on their previous state, the state of other connected depositors, and the strategy of the bank. The bank offers payment to impatient depositors (those who want to withdraw their funds) who accept or decline them with certain probability, depending on the offered amount. Our principal aim is to see what are the optimal offers of the bank if it wants to keep the expected chance of a bank run under a certain level and minimize its expected payments, while taking into account the connection structure of the depositors. We show that in the case of the proposed model this question results in a nonlinear optimization problem with nonlinear constraints and that the method is capable of accounting for time‐varying resource limits of the bank. Optimal offers increase (a) in the degree of the depositor, (b) in the probability of being hit by a liquidity shock, and (c) in the effect of a neighboring impatient depositor.
Effect of Japanese Kampo Medicine Therapy for Menopausal Symptoms after Treatment of Gynecological Malignancy
Authors: Yoshimura Akihiko , Sawada Kenjiro , Sasano Tomoyuki , Kuroda Hiromasa , Kozasa Katsumi , Nakatsuka Erika , Nakamura Koji , Hashimoto Kae , Mabuchi Seiji , Kimura Tadashi
Published: April 2018

Loss of ovarian function by the treatment for gynecological malignancy results in a drastic decrease of estrogen causing physical and mental symptoms. The purpose of this study is to evaluate the effect of Japanese Kampo Kamikihito (KKT) and Kamishoyosan (KSS) on menopausal symptoms in gynecological cancer patients. Patients who had menopausal symptoms after gynecologic malignancy treatment were enrolled and randomly divided into a KKT or a KSS group. Kupperman Menopausal Index (KI) questionnaires were obtained before tumor treatment, at baseline, and at 4 and 8 weeks. Changes in KI scores and severity of each symptom were evaluated. A total of 33 patients were enrolled: 18 in the KKT group and 15 in the KSS group. The KI scores significantly decreased at 4 and 8 weeks compared with baseline in both groups. Although no significant difference was found in change in KI scores between the KKT and KSS groups, efficacy showed some differences. Both KKT and KSS were effective for insomnia, vertigo, and palpitation. KSS was also effective for vasomotor symptoms and arthralgia/myalgia. In conclusion, both KKT and KSS were effective for menopausal symptoms in patients after gynecological tumor treatment. Tailor-made Kampo therapy may contribute to improve patients’ physical and mental symptoms.
A Review of the Literature of Surgical and Nonsurgical Treatments of Invasive Squamous Cells Carcinoma
Authors: Potenza Concetta , Bernardini Nicoletta , Balduzzi Veronica , Losco Luigi , Mambrin Alessandra , Marchesiello Anna , Tolino Ersilia , Zuber Sara , Skroza Nevena , Proietti Ilaria
Published: April 2018

Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with Malpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC usually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive forms of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes. Treatment options for invasive cSCCs include both surgical and nonsurgical options. The therapeutic choice depends on several factors, such as anatomic location, risk factors for tumor recurrence, age, and health status of the patient. This review aims to provide an overview of the current evidence on therapeutic surgical and nonsurgical management of invasive cSCC.
Advances on the BRAF Front in Colorectal Cancer
Authors: Janku Filip
Published: April 2018

Summary: Colorectal cancer with BRAFV600E mutation can be effectively treated with combination approaches involving inhibition of BRAF, MEK, and EGFR proteins. However, activation of the MAPK pathway, often due to emergence of previously undetected molecular alterations, ultimately leads to adaptive therapeutic resistance. Novel combination strategies combining inhibition of BRAF, ERK, and EGFR can be used to prevent MAPK pathway–driven resistance and warrant further investigation. Cancer Discov; 8(4); 389–91. ©2018 AACR.

See related article by Corcoran et al., p. 428.

See related article by Hazar-Rethinam et al., p. 417.
Re(de)fining Innate Lymphocyte Lineages in the Face of Cancer
Authors: Chou Chun , Li Ming O.
Published: April 2018

Innate lymphocytes play critical roles in maintaining tissue homeostasis and integrity of the host at steady state and during pathogenic insults. The successive identification of new innate lymphocyte subsets has revealed an incredible diversity within the family. While this heterogeneous population can be grouped based on their cytotoxic potential into exclusively cytokine-producing helpers and cytolytic killers, the exact developmental relationships between the subsets are not fully understood. The former group is enriched at mucosal surfaces, whereas innate lymphocytes with cytotoxic potential can be identified in a wider array of tissues, including tumors. Although their cytotoxicity suggests an antitumor role, the nature of tumor-elicited innate lymphocyte responses has only begun to be investigated, and the identities of participating subsets still remain contentious. In this review, we provide a brief overview of innate lymphocyte biology, review the current knowledge on their ontogeny, and discuss their roles in tumor immunosurveillance. Cancer Immunol Res; 6(4); 372–7. ©2018 AACR.
Rulers and Dividers: A Technology of Design
Authors: Luscombe Philip
Published: April 2018

Rulers and dividers are both tools that enable the discovery and definition of distances. While similar in their capabilities, however, there is a fundamental difference in the nature of the two tools. A ruler may be used to specify distances according to standardized systems of measurement (for example, inches or millimetres), whereas dividers are used to define proportional relationships. This paper compares the techniques associated with the two tools, in an approach that draws on the theory of extended mind (the idea that cognition is distributed across both people and things) to demonstrate how we might better understand the ways techniques can steer, support, or potentially compromise processes of design.
Probable Maximum Precipitation: Its Estimation and Uncertainty Quantification Using Bivariate Extreme Value Analysis
Authors: Ben Alaya M. A. , Zwiers F. , Zhang X.
Published: April 2018

Probable maximum precipitation (PMP) is the key parameter used to estimate the probable maximum flood (PMF), both of which are important for dam safety and civil engineering purposes. The usual operational procedure for obtaining PMP values, which is based on a moisture maximization approach, produces a single PMP value without an estimate of its uncertainty. We therefore propose a probabilistic framework based on a bivariate extreme value distribution to aid in the interpretation of these PMP values. This 1) allows us to evaluate estimates from the operational procedure relative to an estimate of a plausible distribution of PMP values, 2) enables an evaluation of the uncertainty of these values, and 3) provides clarification of the impact of the assumption that a PMP event occurs under conditions of maximum moisture availability. Results based on a 50-yr Canadian Centre for Climate Modelling and Analysis Regional Climate Model (CanRCM4) simulation over North America reveal that operational PMP estimates are highly uncertain and suggest that the assumption that PMP events have maximum moisture availability may not be valid. Specifically, in the climate simulated by CanRCM4, the operational approach applied to 50-yr data records produces a value that is similar to the value that is obtained in our approach when assuming complete dependence between extreme precipitation efficiency and extreme precipitable water. In contrast, our results suggest weaker than complete dependence. Estimates from the operational approach are 15% larger on average over North America than those obtained when accounting for the dependence between precipitation efficiency and precipitable water extremes realistically. A difference of this magnitude may have serious implications in engineering design.
The Effect of Hydrometeors on MSU/AMSU Temperature Observations over the Tropical Ocean
Authors: Pahlavan Hamid A. , Fu Qiang , Wallace John M.
Published: April 2018

The temperature of Earth’s atmosphere has been monitored continuously since late 1978 by the Microwave Sounding Unit (MSU) and the Advanced Microwave Sounding Unit (AMSU) flown on polar-orbiting weather satellites. It is well known that these measurements are affected by the scattering and emission from hydrometeors, including cloud water, precipitation, and ice particles. In this study the hydrometeor effects on MSU/AMSU temperature observations are investigated by comparing satellite-observed temperature of the middle troposphere (TMT) with synthetic TMT constructed using temperature fields from ECMWF Interim [ERA-Interim (ERA-I)]. Precipitation data have been used to estimate how much of the difference between these two TMT fields is due to hydrometeor contamination effects. It is shown that there exists a robust linear proportionality between TMT deficit (i.e., the measured TMT minus the synthetic TMT) and precipitation at individual grid points in monthly mean fields. The linear correlation is even stronger in the annual mean and seasonally varying climatology and also in the spatial pattern of ENSO-related anomalies. The linear regression coefficient obtained in all of these analyses is virtually identical: −0.042 K (mm day−1)−1. The channel that senses lower-tropospheric temperature (TLT) is more sensitive to precipitation than the TMT channel: the regression coefficient is −0.059 K (mm day−1)−1. It is shown that correcting the TMT or TLT monthly anomalies by removing the hydrometeor contamination does not significantly influence estimates of tropical mean temperature trends, but it could affect the pattern of temperature trend over the tropical oceans.
Evolution of GLM-Observed Total Lightning in Hurricane Maria (2017) during the Period of Maximum Intensity
Authors: Fierro Alexandre O. , Stevenson Stephanie N. , Rabin Robert M.
Published: April 2018

Total lightning data obtained from the Geostationary Lightning Mapper (GLM) were analyzed to present a first glimpse of relationships with intensity variations and convective evolution in Hurricane Maria (2017). The GLM has made it possible, for the first time, to analyze total lightning within a major hurricane for a long period, far from ground-based detection networks. It is hoped that these observations could enlighten some of the complex relationships existing between intensity fluctuations and the distribution of electrified convection in these systems.

Prior to rapidly intensifying from a category 1 to category 5 storm, Maria produced few inner-core flashes. Increases in total lightning in the inner core ( r ≤ 100 km) occurred during both the beginning and end of an intensification cycle, while lightning increases in the outer region (100 < r ≤ 500 km) occurred earlier in the intensification cycle and during weakening. Throughout the analysis period, the largest lightning rates in the outer region were consistently located in the southeastern quadrant, a pattern consistent with modeling studies of electrification within hurricanes. Lightning in the inner core was generally tightly clustered within a 50-km radius from the center and most often found in the southeastern portion of the eyewall, which is atypical. Bootstrapped correlation statistics revealed that the most robust and systematic relationship with storm intensity was obtained for inner-core lightning and maximum surface wind speed. A brief comparison between flash rates from GLM and a very low-frequency ground-based network revealed that not all lightning peaks are seen equally, with hourly flash-rate ratios between both systems sometimes exceeding two orders of magnitude.
Validation of Mountain Precipitation Forecasts from the Convection-Permitting NCAR Ensemble and Operational Forecast Systems over the Western United States
Authors: Gowan Thomas M. , Steenburgh W. James , Schwartz Craig S.
Published: April 2018

Convection-permitting ensembles can capture the large spatial variability and quantify the inherent uncertainty of precipitation in areas of complex terrain; however, such systems remain largely untested over the western United States. In this study, we assess the capabilities of deterministic and probabilistic cool-season quantitative precipitation forecasts (QPFs) produced by the 10-member, convection-permitting (3-km horizontal grid spacing) NCAR Ensemble using observations collected by SNOTEL stations at mountain locations across the western United States and precipitation analyses from PRISM. We also examine the performance of operational forecast systems run by NCEP including the High Resolution Rapid Refresh (HRRR) model, the NAM forecast system with a 3-km continental United States (CONUS) nest, GFS, and the Short-Range Ensemble Forecast system (SREF). Overall, we find that higher-resolution models, such as the HRRR, NAM-3km CONUS nest, and an individual member of the NCAR Ensemble, are more deterministically skillful than coarser models, especially over the narrow interior ranges of the western United States, likely because they better resolve topography and thus better simulate orographic precipitation. The 10-member NCAR Ensemble is also more probabilistically skillful than 13-member subensembles composed of each SREF dynamical core, but less probabilistically skillful than the full 26-member SREF, as a result of insufficient spread. These results should help guide future short-range model development and inform forecasters about the capabilities and limitations of several widely used deterministic and probabilistic modeling systems over the western United States.
The Relationship Between Self-Control and Friendship Conflict: An analysis of Friendship Pairs
Authors: Boman John H. , Mowen Thomas J. , Castro Erin D.
Published: April 2018

While Gottfredson and Hirschi’s general theory of crime is one of the most empirically tested theories of deviance, the theory offers hypotheses that range far beyond how self-control should affect behavior. This study is broadly focused on how self-control operates between friends by considering how the general theory’s main construct relates to friendship conflict. Using a large dyadic dataset, three-level hybrid item-response models regress the actor’s proclivity to experience conflict with the friend onto measures of the actor’s self-control, the friend’s self-control, and an interaction between the self-control estimates. Results demonstrate that the actor’s and the friend’s self-control both significantly relate to friendship conflict, as the theory would expect. However, the actor’s and friend’s levels of self-control do not interact.
Biomechanics of Immediate Postextraction Implant Osseointegration
Authors: Yuan X. , Pei X. , Zhao Y. , Li Z. , Chen C.H. , Tulu U.S. , Liu B. , Van Brunt L.A. , Brunski J.B. , Helms J.A.
Published: April 2018

The aim of this study was to gain insights into the biology and mechanics of immediate postextraction implant osseointegration. To mimic clinical practice, murine first molar extraction was followed by osteotomy site preparation, specifically in the palatal root socket. The osteotomy was positioned such that it removed periodontal ligament (PDL) only on the palatal aspect of the socket, leaving the buccal aspect undisturbed. This strategy created 2 distinct peri-implant environments: on the palatal aspect, the implant was in direct contact with bone, while on the buccal aspect, a PDL-filled gap existed between the implant and bone. Finite element modeling showed high strains on the palatal aspect, where bone was compressed by the implant. Osteocyte death and bone resorption predominated on the palatal aspect, leading to the loss of peri-implant bone. On the buccal aspect, where finite element modeling revealed low strains, there was minimal osteocyte death and robust peri-implant bone formation. Initially, the buccal aspect was filled with PDL remnants, which we found directly provided Wnt-responsive cells that were responsible for new bone formation and osseointegration. On the palatal aspect, which was devoid of PDL and Wnt-responsive cells, adding exogenous liposomal WNT3A created an osteogenic environment for rapid peri-implant bone formation. Thus, we conclude that low strain and high Wnt signaling favor osseointegration of immediate postextraction implants. The PDL harbors Wnt-responsive cells that are inherently osteogenic, and if the PDL tissue is healthy, it is reasonable to preserve this tissue during immediate implant placement.
Structural Determinants and Children’s Oral Health: A Cross-National Study
Authors: Baker S.R. , Foster Page L. , Thomson W.M. , Broomhead T. , Bekes K. , Benson P.E. , Aguilar-Diaz F. , Do L. , Hirsch C. , Marshman Z. , McGrath C. , Mohamed A. , Robinson P.G. , Traebert J. , Turton B. , Gibson B.J.
Published: April 2018

Much research on children’s oral health has focused on proximal determinants at the expense of distal (upstream) factors. Yet, such upstream factors—the so-called structural determinants of health—play a crucial role. Children’s lives, and in turn their health, are shaped by politics, economic forces, and social and public policies. The aim of this study was to examine the relationship between children’s clinical (number of decayed, missing, and filled teeth) and self-reported oral health (oral health–related quality of life) and 4 key structural determinants (governance, macroeconomic policy, public policy, and social policy) as outlined in the World Health Organization’s Commission for Social Determinants of Health framework. Secondary data analyses were carried out using subnational epidemiological samples of 8- to 15-y-olds in 11 countries ( N = 6,648): Australia (372), New Zealand (three samples; 352, 202, 429), Brunei (423), Cambodia (423), Hong Kong (542), Malaysia (439), Thailand (261, 506), United Kingdom (88, 374), Germany (1498), Mexico (335), and Brazil (404). The results indicated that the type of political regime, amount of governance (e.g., rule of law, accountability), gross domestic product per capita, employment ratio, income inequality, type of welfare regime, human development index, government expenditure on health, and out-of-pocket (private) health expenditure by citizens were all associated with children’s oral health. The structural determinants accounted for between 5% and 21% of the variance in children’s oral health quality-of-life scores. These findings bring attention to the upstream or structural determinants as an understudied area but one that could reap huge rewards for public health dentistry research and the oral health inequalities policy agenda.
Discrimination, Harassment, and Gendered Health Inequalities: Do Perceptions of Workplace Mistreatment Contribute to the Gender Gap in Self-reported Health?
Authors: Harnois Catherine E. , Bastos João L.
Published: April 2018

This study examines the extent to which discrimination and harassment contribute to gendered health disparities. Analyzing data from the 2006, 2010, and 2014 General Social Surveys ( N = 3,724), we ask the following: (1) To what extent are perceptions of workplace gender discrimination and sexual harassment associated with self-reported mental and physical health? (2) How do multiple forms of workplace mistreatment (e.g., racism, ageism, and sexism) combine to structure workers’ self-assessed health? and (3) To what extent do perceptions of mistreatment contribute to the gender gap in self-assessed health? Multivariate analyses show that among women, but not men, perceptions of workplace gender discrimination are negatively associated with poor mental health, and perceptions of sexual harassment are associated with poor physical health. Among men and women, perceptions of multiple forms of mistreatment are associated with worse mental health. Gender discrimination partially explains the gender gap in self-reported mental health.
Antisocial Personality Disorder With or Without Antecedent Conduct Disorder: The Differences Are Psychiatric and Paraphilic
Authors: DeLisi Matt , Drury Alan J. , Caropreso Daniel , Heinrichs Tim , Tahja Katherine N. , Elbert Michael J.
Published: April 2018

Antisocial personality disorder (ASPD) requires a childhood diagnosis of conduct disorder (CD); however, some adult offenders are nevertheless diagnosed with ASPD without antecedent CD. The current study used a population of federal correctional clients to examine psychiatric and paraphilic conditions that potentially differentiate these offenders. Attention deficit hyperactivity disorder (ADHD) was associated with a 120% increased likelihood of ASPD with prior CD, but a 75% reduced likelihood of ASPD without CD. Bipolar I disorder was associated with a 328% increased likelihood, frotteurism conferred a 311% increased likelihood, and sexual sadism conferred a 1,033% increased likelihood of ASPD without CD. The findings provide specificity to the heterogeneous ASPD population and help to clarify its equifinality. Implications for correctional practice are that prior psychiatric diagnoses and paraphilic disorders can help to understand the development of serious criminal behavior occurring among adult offenders even if they lacked CD.
Buzz and Pipelines: Knowledge and Decision-Making in a Global Business Services Precinct
Authors: Ville Simon , Wright Claire
Published: April 2018

This paper provides a historical analysis of an urban services district through its examination of the Melbourne wool trade precinct in the 1920s. It is a study of both a local and global community whose social and spatial interaction facilitated large-scale trade of a complex commodity that has rarely been examined. Geographic mapping of the local and global connections of the precinct has been combined with archival evidence. It reveals the “buzz” of the Melbourne precinct, created by local social and professional connections among wool brokers and buyers. “Pipelines” to wool growing and textile regions were developed through overseas branches of firms, with global knowledge exchanged through correspondence, telegraph, and migration. These features shaped the progress of the trade, facilitating improvements in its infrastructure and in the ability of Melbourne’s wool brokers and buyers to fulfill their role as intermediaries in the global supply chain for this complex commodity.
Duality and Fallibility in Practices of the Self: The ‘inclusive subject’ in diversity training
Authors: Brewis Deborah N.
Published: April 2018

The concept of ‘inclusion’ has been gaining ground in a field known as equality and diversity work. Scholars have begun to both theorise what this concept means as a normative goal and to critically examine how it is mobilised in organisational practice. This paper contributes to the latter conversation by asking what comes to count as ‘doing inclusion’ at the level of the individual. I examine the practices of diversity training in United Kingdom organisations, in which diversity practitioners seek to transform their trainees into people who will act inclusively toward others, asking: Who is the ‘inclusive subject’ that is being constructed – imagined, sought and legitimised – through diversity training? What are the conditions of possibility that shape the emergence of this subject? And what are the possibilities that this subject affords to marginalised groups struggling for recognition within organisations? The analysis mobilises Foucault’s notions of power/knowledge, discipline, and practices of the self to describe and discuss the performance of inclusive subjectivity in the context of diversity training in the UK. The practices described are found to be facilitated by two key forms of knowledge about how the subject is characterised: duality and fallibility. The discussion of these two forms of knowledge leads us to consider the relations of both discipline and freedom that take place in diversity training.
Full-Scale Performance Evaluations of Various Wire-Backed Nonwoven Silt Fence Installation Configurations
Authors: Whitman J. Blake , Zech Wesley C. , Donald Wesley N. , LaMondia Jeffrey J.
Published: April 2018

Silt fences have long been a key component for controlling construction stormwater runoff; nonetheless, many silt fence installations fail to perform in the field as intended. Silt fences are temporary sediment control measures used to retain sediment by impounding runoff and allowing for sedimentation on-site, while simultaneously discharging stormwater runoff at a controlled rate. This study evaluated the performance of eight alternative configurations of the Alabama Department of Transportation (ALDOT) standard wire-backed, nonwoven silt fence. Standard installation parameters associated with the ALDOT silt fence include (1) 32-in. (81.3-cm) high fence, (2) 0.95 lb/ft (1.4 kg/m) support T-post, and (3) 10 ft (3.0 m) T-post spacing. Throughout the series of configurations tested, these standard parameters were varied individually and jointly in efforts to improve overall performance. Variations to the standard parameters include (1) 24-in. (61.0-cm) high fence, (2) 1.25 lb/ft (1.9 kg/m) support T-post, (3) 5 ft (1.5 m) T-post spacing, and (4) trench offsetting. Performance analyses were conducted on each configuration and results were evaluated to determine the best overall configuration to enhance the in-field performance of the ALDOT silt fence. Ultimately, the offset 24 in. (61.0 cm) fence with 1.25 lb/ft (1.9 kg/m) T-post spaced 5 ft (1.5 m) on-center resulted in the best overall improvement, retaining an average of 93% of sediment and deflection of only 0.18 ft (0.004 m) over the course of three simulated storm events.