bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world usage and effectiveness of recombinant factor IX Fc in haemophilia B from the B-SURE study in France
Authors: Chambost Hervé , Repessé Yohann , Genre-Volot Fabienne , Desprez Dominique , Castet Sabine Marie , Vanderbecken Stéphane , Zidi Meriem , Gandossi Corinne , Nüesch Eveline , Palmborg Helena , Santagostino Elena ,   for the B-SURE Study Group
Published: January 2025

Background:

More real-world data are needed to complement existing phase III studies on the efficacy and safety of recombinant factor IX Fc fusion protein (rFIXFc) in people with haemophilia B.

Objectives:

We report final data from the B-SURE study, evaluating the real-world usage and effectiveness of rFIXFc in France.

Methods:

Previously treated patients (all ages/severities) received on-demand or prophylactic rFIXFc during B-SURE. Annualised bleeding rate (ABR), injection frequency (IF) and factor consumption (FC) were prospectively evaluated for patients on rFIXFc prophylaxis (primary endpoints). Six months of retrospective factor IX (FIX) data were collected for comparison; patients with ⩾3 months of treatment pre- and post-switch to rFIXFc were analysed.

Design:

B-SURE was a 24-month, prospective, non-interventional, real-world study across haemophilia treatment centres in France.

Results:

Ninety-one male patients enrolled across 21 centres (34% <18 years, 89% severe haemophilia B). Eighty-four patients received prophylaxis at rFIXFc initiation; mean prospective observation period was 21.5 months. Sixty-eight of 84 patients had prior FIX prophylaxis; on rFIXFc prophylaxis, these patients achieved low median ABR (1.2), IF (47.45 injections/year) and mean FC (2844 IU/kg/year). Compared with previous FIX, mean ABR was reduced by 40% ( n = 63); mean IF and FC were reduced by 38.20 injections/year and 1008 IU/kg/year ( n = 57). In patients with prior FIX on-demand ( n = 15), mean ABR reduced by 84% on rFIXFc prophylaxis ( n = 14), mean IF reduced by 2.13 injections/year and mean FC increased by 381.8 IU/kg/year ( n = 15). Most physicians and patients were satisfied/highly satisfied with rFIXFc prophylaxis. rFIXFc was well tolerated with no new safety concerns.

Conclusion:

Findings support the safety and effectiveness of rFIXFc, with reduced IF and FC while maintaining/improving bleed protection. Trial registration: NCT03655340.
Plain Language Summary of Publication: The ProLOGUE study investigating brodalumab in people with plaque psoriasis
Authors: Imafuku Shinichi , Ohata Chika , Honma Masaru , Saeki Hidehisa , Mizutani Yoko , Miyagi Takuya , Murotani Kenta , Kanai Yasumasa
Published: January 2025

What is this summary about?

This summary describes the results of the ProLOGUE study, which tested the effects of brodalumab in Japanese people with plaque psoriasis using outcomes mostly reported by the study participants.

What happened in the study?

Seventy-three adults with plaque psoriasis received brodalumab for 48 weeks. Doctors reported the effects of brodalumab on the extent and severity of psoriasis, while study participants reported its effects on health-related quality of life, overall health status, psoriasis severity, itch, skin pain, anxiety and depressive symptoms, sleep, general activity, work productivity and income loss, and how satisfied they were with brodalumab as a treatment.

What were the results?

Before receiving brodalumab, study participants reported that psoriasis symptoms, particularly itching and depressive symptoms, greatly impacted them and affected their ability to take part in daily activities, work effectively, and earn an income. Brodalumab improved the extent and severity of psoriasis according to doctors, and improved health-related quality of life, overall health status, most psoriasis symptoms, general activity, work productivity, and income loss according to study participants. Brodalumab was also considered an effective, convenient, and beneficial treatment by study participants. Although brodalumab treatment was associated with improvements in the objective (doctor-assessed) measures of symptoms (Psoriasis Area and Severity Index (PASI) scores), some study participants felt their health-related quality of life was still affected by psoriasis, with itching the most troublesome remaining symptom.

What do the results mean?

Brodalumab effectively treats psoriasis. However, doctors and patients have different views on the effects of treatment; therefore, patients’ concerns should be taken into consideration when deciding on a treatment plan.

Trial registration: You can read more about the ProLOGUE study on the following website: Japan Registry of Clinical Trials ( https://jrct.niph.go.jp/en-latest-detail/jRCTs031180037 ; jRCTs031180037). The study was conducted from October 2017 to March 2020. It is completed and there are no plans for follow-up studies.
Vibrations of concrete beams under far-field blasts: A comparative study of two continuum-based approaches
Authors: Fayadh Omer K , Farhan Raad S , Kurdi Nahidh H
Published: January 2025

Existing methods for analysing concrete beams under blast loads are predominantly numerical or simplified analytical models with a single degree of freedom. In this paper, two novel continuum-based approaches are presented to address this gap. The first approach, while analytically elegant, relies on assuming a uniform crack distribution. This unrealistic distribution produced results quite in disagreement with experiment. That limited its application to benchmarking purposes. The second approach, a more sophisticated implicit central difference method, incorporates a more realistic crack pattern approximation. This method was validated against experimental data for far-field and near-field blast scenarios, demonstrating good agreement with experiment. Numerical experimentation revealed the significant impact of the crack distribution on the maximum displacement of the beam. The results given by the first analytical approximation demonstrated that the maximum vibration amplitudes obtained when such unrealistic spatial distributions of cracks are assumed would hover around a tenth of the real ones. However, the second method, with its realistic crack modelling, closely captured the observed experimental behaviour, offering a reliable and efficient tool for the analysis of concrete beams under blast loads.
Is there a risk of esketamine misuse in clinical practice?
Authors: Roncero Carlos , Merizalde-Torres Milton , Szerman Néstor , Torrens Marta , Vega Pablo , Andres-Olivera Pilar , Javier Álvarez Francisco
Published: January 2025

In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years. As the S-enantiomer of ketamine, esketamine’s dosing guidelines and strict medical supervision stem from prior research on ketamine’s use in depression and history as a recreational drug. Despite initial concerns, long-term clinical studies have not documented instances of abuse, misuse, addiction or withdrawal, and the same was found in case reports or subsamples of high-risk populations with comorbidities such as substance use disorder or alcohol use disorder. Esketamine has proven to be safe and well tolerated without fostering new-onset substance use in vulnerable groups. Real-world studies reinforced these observations, reporting no adverse events (AEs) related to pharmacological interactions of esketamine with any other substance, and no new-onset drug or alcohol misuse, craving, misuse or diversion of use. Reports of esketamine craving remain rare, with only one case report documented in 2022. Most drug-related AEs reported in pharmacovigilance databases are those identified in the product’s technical data sheet and with known reported frequency. More importantly, no register of illicit acquisition of esketamine or its tampering for obtaining ketamine or other altered products was found in our search. Overall, our review confirms esketamine’s safety across diverse patient populations, reassuring its responsible use and the scarcity of reports of abuse or misuse since its introduction to the market.
Revolutionizing film commerce: The emergence of streaming platforms
Authors: Singh Guninder Pal , Kumar Abhishek , Rastogi Saumya
Published: January 2025

The case explores the impact of on-demand streaming platforms on film production, distribution, and consumption. It discusses how the business models and the film value chain have transformed, specifically the idea of the theatrical window and viewers’ preferences. It also discusses how algorithms identify and reach new audience segments across the globe, significantly broadening the reach. Access to newer audience segments gives assurance of market potential both for studios to tap into newer markets and for the creatives to experiment with new content forms and subjects. Through the lens of Tyler, a film studio executive looking to produce films suited to the Indian film market, the case helps understand portfolio selection based on risk and reward. This is based on several factors related to content, distribution, actors, and genres. Tyler wants to capitalize on these nuances to identify an audience-film fit for his studio’s foray into the Indian film industry.
Phage therapy in the management of respiratory and pulmonary infections: a systematic review
Authors: Sarkodie-Addo Patience , Osman Abdul-Halim , Aglomasa Bill Clinton , Donkor Eric S.
Published: January 2025

Background:

Lower respiratory tract infections (LRTIs) pose a significant threat to global health, causing more than 2 million deaths worldwide. This menace is intensified by the alarming increase in drug resistance, which limits the availability of effective antibiotics for bacterial respiratory infections. Consequently, there is an urgent demand for alternative therapeutic options. Phage therapy (PT) has re-emerged as a promising therapeutic approach and as an adjunct to antibiotic treatment.

Objective:

This systematic review synthesises the application of PT for LRTIs in humans, providing unified and updated data on the evaluation of the safety and efficacy of PT for LRTIs.

Design:

Systematic review.

Data sources and methods:

Following the PRISMA guidelines, a comprehensive search strategy was carried out (spanning January 2000 – February 2024) in four databases: PubMed, Scopus, ScienceDirect and Web of Science to retrieve published records of PT for LRTIs in humans only. The reference list of each included study was evaluated for possible inclusion of other relevant articles.

Results:

Among the 18 records that fulfilled the inclusion criteria, 70 patients were administered PT. Microbiologically, 71.42% ( n = 50/70) of the patients improved; with either the eradication of the pathogen or a decrease in bacterial load, whilst 15.71% ( n = 11/70) did not record any improvement. About 5.71% (n = 4/70) recorded a partial/incomplete improvement, whilst 7.14% ( n = 5/70) of the patients microbiological outcomes were unspecified. Clinically, up to 74.29% ( n = 52/70) of the patients improved, whilst 10.00% ( n = 7/70) of the patients showed no improvement. Another 2.86% ( n = 2/70) recorded partial/incomplete improvement, whilst 12.86% ( n = 9/70) were uncategorized. Phage titres that yielded positive outcomes ranged from 105 to 1012 PFU/mL. Studies that achieved a substantial phage titre at the site of infection frequently observed notable improvements. Regarding the safety of PT, 77.78% ( N = 14/18) of the studies did not record any adverse effects after PT was administered, whilst 16.66% ( n = 3/18) of the studies reported adverse effects.

Conclusion:

Based on recently published data originating mainly from observational studies, PT has shown considerable efficacy and safety in the treatment of LRTIs. However, there is a lack of uniform methodologies and protocols across different PT cases in the management of LRTIs. Consequently, there is a need for additional clinical studies to establish standardised pharmacokinetic elements and an overall protocol for PT. By doing so, we can fully unlock the potential of PT in effectively managing clinical bacterial infections, including LRTIs.
Experiences and overall impact reported by people living with obesity: results from a multinational study
Authors: Artime Esther , Khare Swarna , Zimner-Rapuch Sarah , Redig Josefine , Flannery Caragh , Higgins Victoria , Leith Andrea , Mortimer Ashley , Halpern Bruno , Alfaris Nasreen
Published: January 2025

Objectives:

To explore the impact of obesity on clinical outcomes, health-related quality of life, emotional well-being, and work productivity in people/patients with obesity across six countries by body mass index and the presence of complications.

Methods:

Adelphi Real World Obesity Disease Specific Programme™ captured data related to physicians and their consulting people/patients with obesity on a weight management program or anti-obesity medication in Brazil, Canada, China, Japan, Kingdom of Saudi Arabia, and the United Arab Emirates from April to December 2022. Physicians reported data for up to eight qualifying people/patients with obesity. People/patients with obesity voluntarily completed outcome measures: 36-Item Short Form Health Survey, emotional well-being, and Work Productivity and Activity Impairment.

Results:

Of 1506 people/patients with obesity, 58% were female (mean ± standard deviation age: 41 ± 12.7 years; body mass index: 32.3 kg/m2 ± 7.7 kg/m2). Overall, 82% had ⩾1 complication (median and interquartile range: 2.0 (1.0–3.0)). People/patients with obesity struggled with weight for a mean ± SD of 64.1 ± 86.6 months with a median (interquartile range) of 3.0 (2.0–5.0) weight-loss attempts. Mean ± standard deviation 36-Item Short Form Health Survey scores for people/patients with obesity above the obesity threshold showed impairment in general health (42.3 ± 11.5), social functioning (44.3 ± 9.2), role-emotional (46.0 ± 9.3), and mental health (45.7 ± 9.6). People/patients with obesity with complications showed similar impairment. People/patients with obesity reported bother/embarrassment about their weight, with 72% worried about future weight gain. Work productivity and activity impairment scores among people/patients with obesity above the obesity threshold showed impairment in activity (36%), overall work (34%), and presenteeism (31%). Findings were similar for people/patients with obesity with complications.

Conclusion:

Results suggest that obesity alongside the presence of complications negatively impacts health-related quality of life, emotional well-being, and work productivity, reinforcing the need for comprehensive interventions for this complex health issue.
Middle meningeal artery embolization for chronic subdural hematoma in a young patient with antiphospholipid syndrome: A case report
Authors: Aagaard Kristoffer Ambeck , Einarsson Halldór Bjarki , Novrup Hans Værum Gram
Published: January 2025

Chronic subdural hematoma is a common condition in neurosurgical practice. It is usually treated by burr-hole surgery. Patients with coagulopathies such as antiphospholipid syndrome, are at increased risk of complications, and careful consideration of the patient’s specific risk of both bleeding and thromboembolic complications must guide medical management. We present the case of a 34-year-old who presented to the neurosurgical department with a chronic subdural hematoma. She had a medical history of triple-positive antiphospholipid syndrome, lupus, and mechanical aortic valve replacement due to Libman-Sacks endocarditis. It was considered of high risk to proceed with traditional burr-hole surgery, so instead embolization of the middle meningeal artery was performed. Postoperatively the patient gradually improved, and a scan at 6 months showed complete regression of the hematoma. She later presented with a contralateral subdural hematoma, which was also successfully treated with middle meningeal artery embolization. Unfortunately, she suffered from an intracerebral hemorrhage shortly afterward, which was treated conservatively by careful management of her anticoagulant therapy. She has now made a full recovery at 4 months follow-up.
Seminoma Diagnosed by Multicancer Detection Testing: A Case Report
Authors: Gilman Elizabeth A. , Ghosh Aditya K. , Seegmiller Sara , Croghan Ivana T. , Hurt Ryan T.
Published: January 2025

A 67-year-old male with positive signals for neuroendocrine and head/neck cancer on a commercially available multicancer detection test underwent an extensive negative diagnostic workup at a local hospital. Referred to our medical center for advanced imaging and endoscopic procedures ultimately led to the diagnosis of an early-stage seminoma with eventual orchiectomy. This case highlights challenges in evaluating positive multicancer detection results, emphasizing the need for a broader understanding of how to interpret these testing results to fully evaluate complex cases, as well as the need for protocolized follow-up approaches to a positive multicancer detection test.
Mucinous tubular and spindle cell carcinoma of the kidney: Clinical, imaging and pathological features
Authors: Oliveira João , Viloria Alejandra , Abreu Simão , Pereira Pedro , Martins-Silva Carlos , Silva João , Antunes Lopes Tiago
Published: January 2025

Background:

Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) is a rare variant of Renal Cell Carcinoma (RCC). MTSCC has been regarded as an indolent subtype of RCC conveying a good prognosis. However, recently some cases of MTSCC have been described presenting or evolving with metastasis, showing an aggressive behaviour. We aim to describe MTSCC clinical characteristics, treatment, prognosis and survival.

Methods:

We retrospectively reviewed all cases of MTSCC diagnosed at our institution from 1 January 2008 to 31 December 2022. Electronic health records were reviewed, and data were retrieved and analysed. This study was approved by our institution’s ethics committee. Data confidentiality was assured.

Results:

We identified eight cases of MTSCC among the 15 years of the study timeframe diagnosed in our hospital. The median age at diagnosis was 59 years (range = 32–80 years), and half of the patients were women (n = 4; 50%). In six (75%) of the patients, presentation was incidental, while the remaining two presented with flank pain. One patient had metastasis at presentation, while the remaining cases were localised at the time of diagnosis. Six patients were submitted to radical nephrectomy: four by open approach and two by transperitoneal laparoscopic approach. Two patients were submitted to a partial nephrectomy by an open approach. Mean (SD) postoperative haemoglobin drop was 2.18 (1.12) g/dL. Median follow-up was 36.5 months (range = 2–157). During the study timeframe, no other patients were diagnosed with local recurrence or distant metastasis. Two patients died during follow-up: the one that was metastatic at diagnosis died due to disease progression 2 months after surgery and another died due to a competitive disease (acute lower limb ischaemia).

Conclusion:

MTSCC is a rare variant of RCC that, despite being initially regarded as an indolent disease with good prognosis, might harbour an aggressive behaviour and grim prognosis.

Level of evidence:

2b
Assessing the acceptability of a sleep-targeted digital intervention among geriatric inpatients: A preliminary study
Authors: Chanteclair Alex , Lartigau Marion , Salles Nathalie , Coelho Julien , Pécune Florian , Philip Pierre , Champeville Clément
Published: January 2025

Background

Sleep complaints are a major concern for the aging population. Insomnia affects quality of life, and is associated with unfavorable geriatric outcomes. Digital technologies offer promising perspectives to assess and support various health conditions, including for the older adults. Among them, the KANOPEE app, a smartphone-based virtual autonomous conversational agent, has been validated in general adult population for insomnia assessment and behavioral interventions. This research primarily aimed to assess the acceptability of the KANOPEE application for evaluating insomnia in older adults. The secondary objective aimed to identify the determinants influencing the acceptability of the app.

Methods

This cross-sectional study included geriatric department inpatients aged 70 or older, undergoing a standardized interview with the app, addressing sleep complaints. Acceptability was assessed using the Acceptability E-Scale (AES) and ECA Trust Questionnaire (ETQ). Sociodemographic and geriatric data were collected for multivariate linear regression analysis to assess determinants of acceptability scores.

Results

Fifty inpatients were included (mean age: 85.8 years, men: 48%), 40% declaring a novice level of familiarity with technology. Insomnia Severity Index mean score was of 8.2, with significant clinical insomnia for 12%. The KANOPEE app showed good acceptability on AES and ETQ scales (respectively 22/30 and 18/24). Familiarity with technology increased credibility in the app (β = 1.5, CI [0.1, 2.9]). Acceptability increased with multimorbidity score (β = 1.5, CI [0.1, 2.2]), and decreased with hearing impairment (β = 1.5, CI [−10.6, −2.8]). Higher depression score decreased trust in the app (β = −0.7, CI [−0.9, −0.4).

Conclusion

This preliminary investigation confirms that older adults can use autonomous virtual agent based applications to quantify their sleep complaints. Understanding and tailoring the unique needs of older users are paramount for successful digital interventions. Further research is needed to confirm these preliminary findings and assess the broader impact of digital apps in a larger sample.
eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models
Authors: Karim Ayesha , Alromema Nashwan , Malebary Sharaf J , Binzagr Faisal , Ahmed Amir , Khan Yaser Daanial
Published: January 2025

Objective

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by various genetic and environmental factors. Currently, there is no definitive clinical test, such as a blood analysis or brain scan, for early diagnosis. The objective of this study is to develop a computational model that predicts ASD driver genes in the early stages using genomic data, aiming to enhance early diagnosis and intervention.

Methods

This study utilized a benchmark genomic dataset, which was processed using feature extraction techniques to identify relevant genetic patterns. Several ensemble classification methods, including Extreme Gradient Boosting, Random Forest, Light Gradient Boosting Machine, ExtraTrees, and a stacked ensemble of classifiers, were applied to assess the predictive power of the genomic features. TheEnsemble Model Predictor for Autism Spectrum Disorder (eNSMBL-PASD) model was rigorously validated using multiple performance metrics such as accuracy, sensitivity, specificity, and Mathew's correlation coefficient.

Results

The proposed model demonstrated superior performance across various validation techniques. The self-consistency test achieved 100% accuracy, while the independent set and cross-validation tests yielded 91% and 87% accuracy, respectively. These results highlight the model's robustness and reliability in predicting ASD-related genes.

Conclusion

The eNSMBL-PASD model provides a promising tool for the early detection of ASD by identifying genetic markers associated with the disorder. In the future, this model has the potential to assist healthcare professionals, particularly doctors and psychologists, in diagnosing and formulating treatment plans for ASD at its earliest stages.
Assessing the costs and savings of telemedicine: Insights from the consolidated framework for implementation research
Authors: Ivanova Julia , Shah Beju , Foote Carrie , Cummins Mollie R.
Published: January 2025

Cost reduction is an often-cited reason to use telemedicine. In assessing telemedicine's cost and value, providers often turn to published cost analyses in the scientific literature for guidance. In this commentary on existing telemedicine cost analysis literature, we discuss the generalizability of these analyses and identify the Consolidated Framework for Implementation Research framework to help assess the applicability of a given cost analysis using inner- and outer-setting constructs. Outer-setting factors—location, practice type, and specialty—can substantially affect telemedicine cost and value, as can the implementation setting. While the body of evidence shows telemedicine may often reduce costs, there is still a need for robust cost analyses to guide implementation decisions as telemedicine becomes a mainstay of healthcare provision. Along with a call for more cost research, we ultimately argue that providers should consider a more holistic, value-based approach to determining when and how telemedicine implementation could benefit healthcare delivery.
Banana Populism: Exploring the Emotionally Engaging, Authentic, and Memeable Rhetoric of Populist Visual Communication
Authors: Szebeni Zea , Hartikainen Ilana , Schmalenberger Sophie , Cole Michael
Published: January 2025

This study conceptualizes “banana populism,” a novel analytical framework to examine how whimsical imagery functions in in contemporary populism. Banana populism utilizes the ordinary—exemplified by the banana—for its ubiquity, inherent humor, and absurdity, transforming these elements into powerful political tools. These articulations effectively mainstream extreme ideologies, invite affective investment from broad publics, and delineate antagonistic frontiers by employing familiar cultural symbols and everyday objects, such as military attire or MAGA hats. Such performative elements not only enhance the authenticity of populist leaders but also make their messages more accessible and emotionally engaging, increasing their appeal and relatability. Furthermore, the memetic nature of banana populism underlines its adaptability and potency on social media, where these performances become part of a participatory and dynamic political discourse. This framework shows how seemingly innocuous visual articulations can profoundly impact political communication and identity formation in contemporary political landscapes.
Twitter (X) and the Commercial Determinants of Health: Characterizing the Most Amplified, Influential, and Connected Voices Driving Twitter Discourse About Tobacco Regulatory Policy From September 2019 to July 2021
Authors: Silver Nathan A. , Feng Miao , Kierstead Elexis C. , Tran Hy , Binns Steven , Emery Sherry , Schillo Barbara A.
Published: January 2025

Tobacco content on Twitter (X) generally opposes regulation. Although a near real-time data source of the public’s response to prominent events heightens the allure of extrapolating public sentiment from Twitter content, tobacco policy sentiment on the platform may be more indicative of industry-affiliated top users. We examined 2 years of tobacco policy discussion on Twitter (X) at the user level ( N = 3,159,807 posts) from September 2019 to July 2021. We sampled the 100 most followed, amplified (retweets), influential (H index), and connected (betweenness centrality) users at three different time periods: pre-COVID (September 2019 to February 2020), COVID lockdown (March 2020 to March 2021), and post vaccine rollout (April to July 2021) to characterize top users. The Louvain method was used to partition users into communities based on retweet behavior. The 100 most amplified users received between 48% and 71% of all retweets across time periods, with e-cigarette advocates dominating the most amplified (64.7%), influential (38.4%) and connected users (42.1%). The vast majority of interaction took place in communities dominated by e-cigarette advocates, but only reaching 2.5% to 8.2% of users. We identified 58 tobacco policy top users who had 1,000 or more total retweets and were among the top 100 for any of our influence metrics at more than one time period. Among top users, 50 were e-cigarette advocates, and 24 had quantifiable ties to the tobacco industry. Practitioners and researchers should be wary of mischaracterizing industry public relations on social media as public sentiment.
The Associations Between Sleep Duration and Various Metabolic Health Indices Among Adults in the United States: A Multivariate Analysis of Variance (MANOVA) Using National Health and Nutrition Examination Survey (NHANES) 2021 to 2023 Dataset
Authors: Feng Shuo , Park Jeong-Hui , Zhang Qiyue , Ma Ping , Lee Jung-Min , Shin Jong Cheol
Published: January 2025

Objective:

This study explores the associations between various sleep durations and metabolic health indices, including systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol levels, high-density lipoprotein (HDL) cholesterol, and waist circumference.

Methods:

Data from the National Health and Nutrition Examination Survey (NHANES) 2021 to 2023, were analyzed. MANOVA and Bonferroni-adjusted ANOVAs were conducted to examine the relationships between sleep duration (sleep deprivation (≤5 h), short sleep (5-7 h), recommended sleep (7-9 h), and long sleep (>9 h)) and metabolic health indices.

Results:

MANOVA revealed significant group differences between sleep duration and metabolic health indices, with Wilks’ Lambda (Λ) = .98, F (3, 5095) = 4.26, P < .001. Compared to recommended sleep duration, both sleep deprivation and short sleep were associated with higher DBP ( Ps < .01) and waist circumference ( Ps < .001), and lower HDL levels ( Ps < .05) Long sleep was associated with lower HDL levels ( P < .01) and lower total cholesterol ( P < .01).

Conclusion:

The study highlights the detrimental associations of both sleep deprivation and short sleep with metabolic health, such as elevated blood pressure and waist circumference, and lowered HDL cholesterol. Long sleep may also negatively impact metabolic health by reducing HDL.
Resilient Leadership and People-Oriented Company Culture in Hospitality: The case of Das Achental Resort in Germany
Authors: Cavelzani Alessandro , Bloyd Nikolai
Published: January 2025

This business case enlightens two key topics: the resilient leadership, and the people-oriented company culture, with specific regard to the hospitality and tourism sector. It provides managers, leaders and business school students in tourism and hospitality with actionable research-based knowledge, reflecting on how leadership could more effectively cope with adversities at the workplace. Secondly, this case study provides also an actionable research-based knowledge about the benefits for companies to adopt a clear and shared organizational culture and company identity.
Occupational Health Nurse Understand the USPFTS (2024) Breast Cancer Screening Guidelines for Average-Risk Workers
Authors: Cadet Myriam Jean , Demezier Isaac Bayard
Published: January 2025

Breast cancer screening helps detect cancer at an early stage. Occupational health nurses must understand the importance of screening to deliver safe care. This article highlights the USPFTS (2024) guidelines on breast cancer screening for average-risk workers.
Measuring Psychopathology in Daily Life
Authors: Wright Aidan G. C. , Ringwald Whitney R. , Zimmermann Johannes
Published: January 2025

Conceptualization and assessment of psychopathology is shifting away from discrete diagnoses to basic dimensions and processes. However, this transition is mostly supported by cross-sectional research, focusing on between-persons differences despite psychopathological processes being conceptualized at the within-persons level. This lack of within-persons research complicates efforts to conceptualize psychopathology as a complex system of interacting domains. We developed a broad inventory of psychopathology suitable for studying within-persons processes in daily life and between-persons differences in those processes. We evaluated the within- and between-persons hierarchical structure of 27 psychopathology constructs and their correlates in a sample ( N = 300) of mixed community and outpatient participants who provided daily ratings (number of days: M = 12.9). Results supported within- and between-persons structures representing key domains of psychopathology (Internalizing, Detachment, Antagonism, Disinhibition, and Anankastia). The inventory (in long and brief formats) appears suitable for studying psychopathology in intensive longitudinal studies. We make all data and code freely available ( https://osf.io/su3gf/ ).
High Modified 5 Factor Frailty Index is Associated With Worse PROMs and Decreased Return to Activities After 1 or 2 Level MI-TLIF
Authors: Subramanian Tejas , Shahi Pratyush , Hirase Takashi , Korsun Maximilian , Zhang Joshua , Kim Eric , Kwas Cole , Kaidi Austin C. , Boddapati Venkat , Song Junho , Asada Tomoyuki , Mai Eric , Simon Chad , Araghi Kasra , Amen Troy B. , Vaishnav Avani , Tuma Olivia , Zhao Eric , Singh Nishtha , Allen Myles , Bay Annika , Sheha Evan , Lovecchio Francis C. , Dowdell James E. , Qureshi Sheeraz A. , Iyer Sravisht
Published: January 2025

Study Design

Retrospective cohort study.

Objective

Frailty is defined as a state of minimal “physiologic reserve.” The modified 5 factor frailty index (mFI-5) is a recently proposed metric for assessing frailty and has been previously studied as a predictor of morbidity and mortality. However, its utility in predicting postoperative patient reported outcomes (PROMs) and return to activities remains understudied.

Methods

This is a retrospective cohort study of patients undergoing 1 or 2 level minimally invasive transforaminal lumbar interbody fusion queried from a prospectively maintained multi-surgeon registry. Comorbidities including hypertension, congestive heart failure, diabetes, chronic obstructive pulmonary disease, and functional status were utilized to calculate the mFI-5. Patients were separated into 3 cohorts, “non-frail,” “moderately frail” or “severely frail” based on their mFI-5. Patient outcomes were compared between the cohorts.

Results

392 patients were included of which 227 patients were non-frail, 134 were moderately frail, and 31 were severely frail. Frail patients had longer operative time ( P = 0.002), greater estimated blood loss ( P = 0.038). Despite similar preoperative PROMs, at a longer term follow up, frail patients also had worse PROM scores for ODI ( P = 0.009), VAS-back ( P = 0.028), and VAS-leg ( P = 0.004). Frail patients had worse preoperative ( P = 0.017) and postoperative ( P < 0.001) SF-12 PCS. At 1-year, frail patients had lower rates of fusion ( P = 0.002). Frail patients also demonstrated lower rates of returning to work ( P = 0.018), returning to driving ( P = 0.027), and discontinuation of narcotics ( P = 0.004).

Conclusion

Frail patients as measured by the mFI-5 index demonstrated worse postoperative outcomes following 1 or 2 level MI-TLIF. Careful patient selection and preoperative optimization may be especially important in frail patients.
Nutritional status of patients with nemaline myopathy and related congenital myopathies in Finland: A pilot study
Authors: Lehtokari Vilma-Lotta , Similä Minna , Tammepuu Marianne , Isohanni Pirjo , Auranen Mari , Hiekkala Sinikka , Wallgren-Pettersson Carina , Strang-Karlsson Sonja
Published: January 2025

Background

The muscle weakness in patients with nemaline myopathy (NM) and related disorders (NMR) often affects the muscles used for eating and dining, and some scientific evidence of poorer nutritional status of patients with myopathy exists. However, comprehensive research on the nutritional status of persons with NM or NMR has not been done.

Objectives

Our aim was to conduct a comprehensive cross-sectional pilot study among adult Finnish patients with NM or NMR to investigate their food consumption, nutrient intakes, selected nutrient-related laboratory parameters in blood, and self-assessed functioning of dining and eating and of the gastrointestinal tract. We also aimed to test the suitability of the methods selected.

Methods

The methods included a questionnaire to investigate eating-related functioning, a food frequency questionnaire, food records, and laboratory analyses from blood samples.

Results

Of 32 invited patients, 20 returned the survey and food frequency questionnaire. Food records were returned by 17, and blood samples were obtained from 16. Food consumption as well as nutrient and energy intake were highly variable between the individuals. Low energy intakes, low consumption of healthy foods, such as fruits, vegetables, and whole grains as well as low intakes of vitamin D, calcium, dietary fiber, vitamin C, folate, and iron were observed. Low nutrient intakes were seen especially in non-ambulatory participants, who also reported challenges in eating and dining related functioning. The laboratory parameters did not indicate severe undernourishment in any of the participants.

Conclusions

Evaluation of food consumption and nutrient intakes were needed to find patients with risk of undernourishment. The results underline the importance of monitoring adequate intake of calcium and vitamin D in this group of patients, especially because of the immobility-induced risk of osteoporosis. Non-ambulatory patients reported more challenges in eating and dining. This, however, did not determine the nutritional status of the patient.
Building a Broad Partnership: The Evolution of Armenia–UAE Relations
Authors: Ghahriyan Mushegh
Published: January 2025

This article aims to examine the relations between the Republic of Armenia and the United Arab Emirates. Using statistical data, official statements, archival materials, and other relevant sources, it discusses the motives of the Republic of Armenia and the United Arab Emirates for developing bilateral relations, analyzes factors impacting those relations, and evaluates the dynamics of their relationships. It employs a multifactor analytical framework that delves into the nuances of bilateral relations and discusses bilateral cooperation in four areas—political ties, economic cooperation, security and defense, and domestic factors and perceptions. They are analyzed in the context of both states’ international environment and foreign policy priorities. The study finds that the two states have consistently grown and broadened their relations, particularly in economic cooperation. On the other hand, this partnership lacks depth and strategic engagement.
From “places that don’t matter” to peripheralization: A geographical approach to understanding the spatialities of the far right
Authors: Mullis Daniel
Published: January 2025

Based on qualitative research in the district of Frankfurt-Riederwald, where the far-right Alternative for Germany (AfD) has been successful in recent years, this paper confronts the mostly quantitatively oriented studies on the spatialities of the far right. For this purpose, peripheralization is introduced as a concept that leads beyond the dominant notion of left-behind places. The concept of peripheralization allows for a relational integration of the economic, individual and emotional dimensions of social reality, rather than understanding them as separate or even competing aspects, and thus provides an understanding of complex, spatialized political formations. Moreover, the concept helps to understand that both the periphery and the center are products of power relations and that both are equally important for the articulation of far-right politics.
E-curating: Evolution of Exhibition Curation in the Digital Age
Authors: Nair Anjchita B.
Published: January 2025

As the landscape of art, museum and exhibitions has evolved, the new visitor’s expectation from an exhibition has also changed significantly. The access and availability of content has resulted in inundating and overwhelming the audience making the curator a mediator who facilitates a meaningful and relevant experience. Even with funding and resource constraints, the opportunities afforded by digital technologies have redefined how a curator discovers, selects and showcases the thematic material. With respect to interpretation, communication and circulation of content as well, digital tools have helped us move beyond traditional methods. This article looks at three different exhibitions with completely different approaches to curation to look at how digital tools have been utilized to make the exhibition experience unique and meaningful for a varied set of audiences. We further explore how different mediums and formats can be used in unusual combinations to make the visitor experience new and exciting. Apart from tangible artforms on display, how digital tools help showcase intangible cultural heritage and their interconnections are also explored. Looking beyond the narrative of creation of virtual museums or AR/VR experiences in the cultural landscape, this article attempts to highlight the digital pathways using simple technological solutions that can enhance the curatorial experience. It demonstrates how the democratization process with digital tools is manifold, in consumption, creation as well curation of art, culture and heritage.
Not Another Post Hoc Paper: A New Look at Contrast Analysis and Planned Comparisons
Authors: Granziol Umberto , Rabe Maximilian , Gallucci Marcello , Spoto Andrea , Vidotto Giulio
Published: January 2025

Before conducting statistical analyses, scholars and researchers often have specific hypotheses about differences between groups of means. Their hypotheses are frequently tested by applying post hoc comparisons with statistically significant simple or interaction effects. With the exception of exploratory studies, using post hoc comparisons can increase Type I error rates and decrease statistical power. A well-known solution involves planning comparisons before the study. However, the coding of such planned comparisons can be difficult to understand and implement, especially for customized comparisons and interaction effects. In this tutorial, we aim to reduce such difficulties by examining all the possible types of planned comparisons, even the customized ones, for both main and interaction effects. In this tutorial, a Shiny App coded in R and called “appRiori” is presented. appRiori is coded to help in understanding both the logic behind the planned comparisons and the way to interpret them when a model is tested. By using empirical examples on reproducible data, we explain how to code any default planned comparison executable in R. Moreover, through some features of appRiori, the customization of planned comparisons is shown, even on interaction effects, such as the possibility of creating customized contrast through click-and-drop menus. For each step, the R code related to the planned comparison is provided. Implications and fields of use of planned comparisons and appRiori are discussed.
An Inception-Cohort Study Quantifying How Many Registered Studies Are Publicly Shared
Authors: Ensinck Eline N. F. , Lakens Daniël
Published: January 2025

We quantified how many studies registered on the OSF up to November 2017 are performed but not shared after at least 4 years. Examining a sample of 169 registered research studies, we found that 104 (61.5%) were publicly shared. We estimate that 5,316 out of 9,172 (58%) registered studies on the OSF are publicly shared. Researchers use registries to make unpublished studies public, and the OSF policy to open registrations after a 4-year embargo substantially increases the number of studies that become known to the scientific community. In responses to emails asking researchers why studies remained unpublished, logistical issues (e.g., lack of time, researchers changing jobs) were the most common cause, followed by null results and rejections during peer review. Our exploratory study shows that a substantial amount of studies that researchers perform remain unpublished.
Effectiveness and safety of eptinezumab in anti-CGRP(R) mAbs-naïve and mAbs-non responders’ patients: A retrospective observational study
Authors: Bellotti Alessia , Podella Caterina , Sarchielli Paola
Published: January 2025

Background and Aim

Eptinezumab is a quarterly intravenous infusion monoclonal antibody (mAb) with high affinity for calcitonin gene related peptide (CGRP) and a long-lasting mechanism of action. In our retrospective observational study, we sought to investigate the effectiveness and safety of eptinezumab both in mAbs-naïve and mAbs-non responders’ patients.

Methods

We collected clinical data from electronic charts of 30 migraineurs who underwent six months of eptinezumab treatment; 18 patients had never undergone mAbs-prophylaxis (G1) while 12 had been non-responders to erenumab/galcanezumab (G2). Monthly Headache Days (MHDs), MIDAS, HIT6 and ASC scores were recorded before eptinezumab (T0) and thereafter every three months. Patients were considered responders whenever MHDs reduction was >50% at six months (T2).

Results

Overall, 25 out of 30 patients (15 in G1 and 10 in G2) were eptinezumab responders (83.3%). Headache frequency (MHDs) at T0 was 12.4 in G1 and 17.0 in G2, while at T2 it was 7.1 in G1 and 8.0 in G2 (p-value < 0.0001). Significant reductions in MIDAS, HIT6 and ASC scores were also observed. No safety concerns were registered.

Conclusions

Based upon our retrospective observational study, eptinezumab might be effective and safe also for those migraineurs who resulted being non-responders to other anti-CGRP(R) mAbs.
State-of-the-art research and corresponding industrial perspective for the use of textured surfaces in machining applications
Authors: Mishra Sarvesh Kumar , J Ilamparithi , Ghosh Sudarsan , Aravindan Sivanandam
Published: January 2025

The subject of surface texturing has been one of the most sought and rigorously researched domains of interest for the research community in the manufacturing field for a few decades. The reason for this is the potential applications of surface texturing techniques in various sectors of manufacturing and services. One of the foremost applications where surface texturing has proven to be highly beneficial is cutting tool manufacturing. There are several other applications of surface texturing like fabrication of aerospace and marine structures where the research is still not well established. Unlike these applications, surface texturing in metal cutting has been established and documented by researchers to a level to get the process implemented in practical industry use cases. The present work critically assesses the work related to surface texturing in metal cutting for tools (cutting tools, drills, milling tools, etc.) that have highlighted the influence of surface texturing on performance improvement. Various manufacturing techniques used to create surface textures and their underlying mechanisms for performance improvement have been discussed. The synergistic effects coupled with the benefits of employing texturing with coatings/ lubrication/ cooling have also been critically analyzed over a wider range of process parameters and work material combinations. Furthermore, the existing finite element (FE) models for textured surfaces have been discussed to identify the ease/complexity of the simulation to achieve the advantages of texturing and their practical validity.