bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Cerebral Amyloid Pathology Based on Plasma Amyloid and Tau Related Markers
Authors: Chen Ting-Bin , Lin Kun-Ju , Lin Szu-Ying , Lee Yi-Jung , Lin Yi-Cheng , Wang Chen-Yu , Chen Jun-Peng , Wang Pei-Ning
Published: October 2021

Background and Purpose:Pyroglutamate-modified β-amyloid peptide (AβpE) is crucial for AD pathophysiological process. The potential associations of plasma AβpEand total tau (t-tau) with brain Aβ burden and cognitive performance remain to be clarified.

Methods:Forty-six subjects with unimpaired cognition, mild cognitive impairment, or very mild dementia were enrolled. Plasma levels of AβpE3−40, t-tau, and Aβ42 were quantified by immunomagnetic reduction (IMR) assays. We analyzed individual and combined biomarker correlations with neuropsychological scores and Aβ positivity determined by18F-florbetapir positron emission tomography (PET).

Results:Both plasma AβpE3−40levels and AβpE3−40/t-tau ratios correlated negatively with short-term memory and global cognition scores, while correlating positively with PET standardized uptake value ratios (SUVRs). Among the biomarkers analyzed, the combination of AβpE3−40in a ratio with t-tau had the best discriminatory ability for Aβ PET positivity. Likewise, logistic regression analysis showed that AβpE3−40/t-tau was a highly robust predictor of Aβ PET positivity after controlling for relevant demographic covariates.

Conclusion:Plasma AβpE3−40/t-tau ratios correlate with cognitive function and cerebral Aβ burden. The suitability of AβpE3−40/t-tau as a candidate clinical biomarker of AD pathology in the brain should be examined further in larger studies.
Fusion Genes Altered in Adult Malignant Gliomas
Authors: You Gan , Fan Xing , Hu Huimin , Jiang Tao , Chen Clark C.
Published: October 2021

Malignant gliomas are highly heterogeneous brain tumors in molecular genetic background. Despite the many recent advances in the understanding of this disease, patients with adult high-grade gliomas retain a notoriously poor prognosis. Fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets to date. Understanding the gene fusions and how they regulate oncogenesis and malignant progression will contribute to explore new approaches for personalized treatment. By now, studies on gene fusions in gliomas remain limited. However, some current clinical trials targeting fusion genes have presented exciting preliminary findings. The aim of this review is to summarize all the reported fusion genes in high-grade gliomas so far, discuss the characterization of some of the most popular gene fusions occurring in malignant gliomas, as well as their function in tumorigenesis, and the underlying clinical implication as therapeutic targets.
Treatment of the Carotid In-stent Restenosis: A Systematic Review
Authors: Huang Hao , Wu Lingshan , Guo Yinping , Zhang Yi , Zhao Jing , Yu Zhiyuan , Luo Xiang
Published: October 2021

Background and Purpose: In-stent restenosis (ISR) after carotid artery stent (CAS) is not uncommon. We aimed to evaluate therapeutic options for ISR after CAS.

Methods: We searched PubMed and EMBASE until November 2, 2020 for studies including the treatment for ISR after CAS.

Results: In total, 35 studies, covering 1,374 procedures in 1,359 patients, were included in this review. Most cases (66.3%) were treated with repeat CAS (rCAS), followed by percutaneous transluminal angioplasty (PTA) (17.5%), carotid endarterectomy (CEA) (14.3%), carotid artery bypass (1.5%), and external beam radiotherapy (0.4%). The rates of stroke & TIA within the postoperative period were similar in three groups (PTA 1.1%, rCAS 1.1%, CEA 1.5%). CEA (2.5%) was associated with a slightly higher rate of postoperative death than rCAS (0.7%, P = 0.046). Furthermore, the rate of long-term stroke & TIA in PTA was 5.7%, significantly higher than rCAS (1.8%, P = 0.036). PTA (27.8%) was also associated with a significantly higher recurrent restenosis rate than rCAS (8.2%, P = 0.002) and CEA (1.6%, P < 0.001). The long-term stroke & TIA and recurrent restenosis rates showed no significant difference between rCAS and CEA.

Conclusions: rCAS is the most common treatment for ISR, with low postoperative risk and low long-term risk. CEA is an important alternative for rCAS. PTA may be less recommended due to the relatively high long-term risks of stroke & TIA and recurrent restenosis.
Better Screening Value of Sylvian Fissure Ratio on Cognitive Decline Among Female Compared to Male: An Observational Study in Elderly Patients With Cerebral Small Vessel Disease in Soochow
Authors: Qin Yiren , Ai Dannan , Jordan Ashly E. , Guo Xiaoning , Li Tan , Diao Shanshan , Zhao Hongru , Liu Yang , Xue Qun , Wang Yueju , Fang Qi
Published: October 2021

Background: Cognitive decline (CD) occurs frequently in elderly patients with cerebral small vessel disease (CSVD). In China, elderly patients are more likely to enter healthcare in community hospitals where no magnetic resonance imaging (MRI) is available. This study aimed to explore the screening value of Sylvian fissure ratio (SFR) on CD and compare its gender difference from community-transferred patients.

Methods: We performed a single-center, observational study (collected between April 1, 2016, and March 1, 2019) to evaluate the association between Montreal Cognitive Assessment (MoCA) and SFR in 203 eligible community-transferred patients. Baseline characteristics of patients were collected during hospitalization. Multiple linear regression analyses were used to estimate the effect of variables on MoCA, and interactions between select variables were analyzed in different models. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminative effect of SFR to severe CD.

Results: We identified that a meaningful SFR cutoff of 0.05 had important screening value (likelihood ratio test, p = 0.067) on CD. The ratio had a lower screen value in males when compared to females (adjusted β, −5.54; 95% CI, −8.78 to −2.30 vs. adjusted β, −1.01; 95% CI, −2.84 to 0.82). The gender difference was further verified by ROC curve analysis, in which this discriminative effect was more potent in females (from 0.878 to 0.948) compared to males (from 0.838 to 0.837).

Conclusion: An SFR of 0.05 may be more useful to distinguish CD in female patients with CSVD than male patients in whom the syndrome is suspected clinically.
Alterations in Electroencephalography Theta as Candidate Biomarkers of Acute Cannabis Intoxication
Authors: Richard Christian D. , Poole Jared R. , McConnell Marissa , Meghdadi Amir H. , Stevanovic-Karic Marija , Rupp Greg , Fink Abigail , Schmitt Rose , Brown Timothy L. , Berka Chris
Published: October 2021

The trend toward cannabis legalization in the United States over the past two decades has unsurprisingly been accompanied by an increase in the number of cannabis users and use patterns that potentially pose wider risks to the public like driving under the influence. As such, it is becoming increasingly important to develop methods to accurately quantify cannabis intoxication and its associated impairments on cognitive and motor function. Electroencephalography (EEG) offers a non-invasive method for quantitatively assessing neurophysiological biomarkers of intoxication and impairment with a high degree of temporal resolution. Twelve healthy, young recreational cannabis users completed a series of neurocognitive tasks with concurrent EEG acquisition using the ABM STAT X24 EEG headset in a within-subject counterbalanced design. The 1-h testbed consisted of resting state tasks and tests of attention and memory. Spectral densities were computed for resting state tasks, and event-related potentials (ERPs) were obtained for the attention and memory tasks. Theta band power (3–5 Hz) was decreased during cannabis intoxication compared to placebo during resting state tasks, as were average P400 and late positive potential (LPP) amplitudes during attention and memory tasks. Cannabis intoxication was also associated with elevated frontal coherence and diminished anterior–posterior coherence in the Theta frequency band. This work highlights the utility of EEG to identify and quantify neurophysiological biomarkers from recordings obtained during a short neurocognitive testbed as a method for profiling cannabis intoxication. These biomarkers may prove efficacious in distinguishing intoxicated from non-intoxicated individuals in lab and real-world settings.
Deep Learning Radiomics to Predict PTEN Mutation Status From Magnetic Resonance Imaging in Patients With Glioma
Authors: Chen Hongyu , Lin Fuhua , Zhang Jinming , Lv Xiaofei , Zhou Jian , Li Zhi-Cheng , Chen Yinsheng
Published: October 2021

Objectives

Phosphatase and tensin homolog (PTEN) mutation is an indicator of poor prognosis of low-grade and high-grade glioma. This study built a reliable model from multi-parametric magnetic resonance imaging (MRI) for predicting the PTEN mutation status in patients with glioma.

Methods

In this study, a total of 244 patients with glioma were retrospectively collected from our center (n = 77) and The Cancer Imaging Archive (n = 167). All patients were randomly divided into a training set (n = 170) and a validation set (n = 74). Three models were built from preoperative MRI for predicting PTEN status, including a radiomics model, a convolutional neural network (CNN) model, and an integrated model based on both radiomics and CNN features. The performance of each model was evaluated by accuracy and the area under the receiver operating characteristic curve (AUC).

Results

The CNN model achieved an AUC of 0.84 and an accuracy of 0.81, which performed better than did the radiomics model, with an AUC of 0.83 and an accuracy of 0.66. Combining radiomics with CNN will further benefit the predictive performance (accuracy = 0.86, AUC = 0.91).

Conclusions

The combination of both the CNN and radiomics features achieved significantly higher performance in predicting the mutation status of PTEN in patients with glioma than did the radiomics or the CNN model alone.
Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer
Authors: Chen Jiayu , Jin Ying , Li Siyi , Qiao Cui , Peng Xinxin , Li Yan , Gu Yu , Wang Wei , You Yan , Yin Jie , Shan Ying , Wang Yong-Xue , Qin Meng , Li Hongyue , Cai Yan , Dong Yu , Peng Siying , Pan Lingya
Published: October 2021

To generate robust patient-derived xenograft (PDX) models for epithelial ovarian cancer (EOC), analyze the resemblance of PDX models to the original tumors, and explore factors affecting engraftment rates, fresh cancer tissues from a consecutive cohort of 158 patients with EOC were collected to construct subcutaneous PDX models. Paired samples of original tumors and PDX tumors were compared at the genome, transcriptome, protein levels, and the platinum-based chemotherapy response was evaluated to ensure the reliability of the PDXs. Univariate and multivariate analyses were used to determine the factors affecting the engraftment rates. The engraftment success rate was 58.23% (92/158) over 3–6 months. The Ki-67 index and receiving neoadjuvant chemotherapy can affect the engraftment rate in primary patients. The PDX models generated in this study were found to retain the histomorphology, protein expression, and genetic alteration patterns of the original tumors, despite the transcriptomic differences observed. Clinically, the PDX models demonstrated a high degree of similarity with patients in terms of the chemotherapy response and could predict prognosis. Thus, the PDX model can be considered a promising and reliable preclinical tool for personalized and precise treatment.
Gaultheria leucocarpa var. yunnanensis for Treating Rheumatoid Arthritis—An Assessment Combining Machine Learning–Guided ADME Properties Prediction, Network Pharmacology, and Pharmacological Assessment
Authors: Wang Xiuhuan , Sun Youyi , Ling Ling , Ren Xueyang , Liu Xiaoyun , Wang Yu , Dong Ying , Ma Jiamu , Song Ruolan , Yu Axiang , Wei Jing , Fan Qiqi , Guo Miaoxian , Zhao Tiantian , Dao Rina , She Gaimei
Published: October 2021

Background: Dianbaizhu (Gaultheria leucocarpa var. yunnanensis), a traditional Chinese/ethnic medicine (TC/EM), has been used to treat rheumatoid arthritis (RA) for a long time. The anti–rheumatic arthritis fraction (ARF) of G. yunnanensis has significant anti-inflammatory and analgesic activities and is mainly composed of methyl salicylate glycosides, flavonoids, organic acids, and others. The effective ingredients and rudimentary mechanism of ARF remedying RA have not been elucidated to date.

Purpose: The aim of the present study is to give an insight into the effective components and mechanisms of Dianbaizhu in ameliorating RA, based on the estimation of the absorption, distribution, metabolism, and excretion (ADME) properties, analysis of network pharmacology, and in vivo and in vitro validations.

Study design and methods: The IL-1β–induced human fibroblast-like synoviocytes of RA (HFLS-RA) model and adjuvant-induced arthritis in the rat model were adopted to assess the anti-RA effect of ARF. The components in ARF were identified by using UHPLC-LTQ-Orbitrap-MSn. The quantitative structure–activity relationship (QSAR) models were developed by using five machine learning algorithms, alone or in combination with genetic algorithms for predicting the ADME properties of ARF. The molecular networks and pathways presumably referring to the therapy of ARF on RA were yielded by using common databases and visible software, and the experimental validations of the key targets conducted in vitro.

Results: ARF effectively relieved RA in vivo and in vitro. The five optimized QSAR models that were developed showed robustness and predictive ability. The characterized 48 components in ARF had good biological potency. Four key signaling pathways were obtained, which were related to both cytokine signaling and cell immune response. ARF suppressed IL-1β–induced expression of EGFR, MMP 9, IL2, MAPK14, and KDR in the HFLS-RA .

Conclusions: ARF has good druggability and high exploitation potential. Methyl salicylate glycosides and flavonoids play essential roles in attuning RA. ARF may partially attenuate RA by regulating the expression of multi-targets in the inflammation–immune system. These provide valuable information to rationalize ARF and other TC/EMs in the treatment of RA.
Quality Control of Glehniae Radix, the Root of Glehnia Littoralis Fr. Schmidt ex Miq., Along its Value Chains
Authors: Chen Yuan , Lei Lujing , Bi Yaqiong , Jiang Linlin , Guo Wenfang , Wang Jianhua , Li Minhui
Published: October 2021

Glehniae Radix (GR) is one of the major medicinal materials in China. The global demand for GR, especially in Asian countries, is constantly increasing, and the supply of wild medicinal materials falls short of the demand. Previous studies have shown that the production and processing modes of different value chains (VCs) impact the quality of medicinal materials. After 4 years of field and market research, this study includes interviews with stakeholders in the VCs, integrates different types of VCs, and further analyzes the VCs. GR characteristics were also assessed; the length and upper-middle diameter of the collected samples were measured, and the effective components of the samples were determined to rank the GR samples according to their quality. The effective components were further analyzed by the K-means clustering method. Concomitantly, the local price (the sales price of the place where the medicinal materials are produced) and market price (the sale price of medicinal materials in the market) of GR in Chifeng, Inner Mongolia, and Anguo, Hebei, were documented, and the ARIMA (Autoregressive Integrated Moving Average) method was used to predict the GR price. Ten VCs are summarized in this article. The results showed that the income of the staff at the beginning of the VC is inadequate. Regarding GR origin, Inner Mongolia GR showed higher quality than that of other areas. As a result, the price of medicinal materials is relatively high, which corresponds to the market price of the survey. The forecast results showed that the market price of GR would increase slightly in the future, which could provide reference for the selection of medicinal materials cultivation in the future. Through the study, it was found that the vertical integration in the VCs of GR could guarantee not only the benefit of the growers but also the traceability of the medicinal materials, which further guarantees the quality of the medicinal materials. However, the complex relationship between the cultivation area and the quality of the medicinal materials is not clear, which should be addressed in future research.
A Review on Drug Delivery System for Tumor Therapy
Authors: Liu Guoxiang , Yang Lina , Chen Guang , Xu Fenghua , Yang Fanghao , Yu Huaxin , Li Lingne , Dong Xiaolei , Han Jingjing , Cao Can , Qi Jingyu , Su Junzhe , Xu Xiaohui , Li Xiaoxia , Li Bing
Published: October 2021

In recent years, with the development of nanomaterials, the research of drug delivery systems has become a new field of cancer therapy. Compared with conventional antitumor drugs, drug delivery systems such as drug nanoparticles (NPs) are expected to have more advantages in antineoplastic effects, including easy preparation, high efficiency, low toxicity, especially active tumor-targeting ability. Drug delivery systems are usually composed of delivery carriers, antitumor drugs, and even target molecules. At present, there are few comprehensive reports on a summary of drug delivery systems applied for tumor therapy. This review introduces the preparation, characteristics, and applications of several common delivery carriers and expounds the antitumor mechanism of different antitumor drugs in delivery carriers in detail which provides a more theoretical basis for clinical application of personalized cancer nanomedicine in the future.
Multi-Chromophore Dyes for Improving Light Stability of Electro-Fluidic Displays
Authors: Deng Yong , Ye Dechao , Guo Yuanyuan , Zhou Guofu , Jiang Hongwei
Published: October 2021

Electro-fluidic display (EFD) is a new reflective display based on electrowetting phenomenon which is applied to the outdoor billboard. Organic dyes are the most important materials for the color gamut and reliability of the EFD devices, which are always synthesized based on mono-chromophore dye in previous work. In this paper, we report our research on azopyrazolone as the chromophore to construct a polychromic macromolecular dye system. The light stability and photo-electric properties of these new dyes are researched detailed. It is found that the light stability of multi-chromophore dyes and backflow properties are much better than corresponding mono-chromophore dye.
Blood Adenosine Increase During Apnea in Spearfishermen Reinforces the Efficiency of the Cardiovascular Component of the Diving Reflex
Authors: Marlinge Marion , Chefrour Mohamed , Billaut François , Zavarro Marion , Rostain Jean-Claude , Coulange Mathieu , Guieu Régis , Joulia Fabrice
Published: October 2021

The physiopathology consequences of hypoxia during breath-hold diving are a matter of debate. Adenosine (AD), an ATP derivative, is suspected to be implicated in the adaptive cardiovascular response to apnea, because of its vasodilating and bradycardic properties, two clinical manifestations observed during voluntary apnea. The aim of this study was to evaluate the adenosine response to apnea-induced hypoxia in trained spearfishermen (SFM) who are used to perform repetitive dives for 4–5 h. Twelve SFM (11 men and 1 woman, mean age 41 ± 3 years, apnea experience: 18 ± 9 years) and 10 control (CTL) subjects (age 44 ± 7 years) were enrolled in the study. Subjects were asked to main a dry static apnea and stopped it when they began the struggle phase (average duration: SFM 120 ± 78 s, CTL 78 ± 12 s). Capillary blood samples were collected at baseline and immediately after the apnea and analyzed for standard parameters and adenosine blood concentration ([AD]b). Heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressures were also recorded continuously during the apnea. During the apnea, an increase in SBP and DBP and a decrease in HR were observed in both SFM and CTL. At baseline, [AD]b was higher in SFM compared with CTL (1.05 ± 0.2 vs. 0.73 ± 0.11 μM, p < 0.01). [AD]b increased significantly at the end of the apnea in both groups, but the increase was significantly greater in SFM than in controls (+90.4 vs. +12%, p < 0.01). Importantly, in SFM, we also observed significant correlations between [AD]b and HR (R = −0.8, p = 0.02), SpO2 (R = −0.69, p = 0.01), SBP (R = −0.89, p = 0.02), and DBP (R = −0.68, p = 0.03). Such associations were absent in CTL. The adenosine release during apnea was associated with blood O2 saturation and cardiovascular parameters in trained divers but not in controls. These data therefore suggest that adenosine may play a major role in the adaptive cardiovascular response to apnea and could reflect the level of training.
Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1
Authors: Mollah Md. Mahi Imam , Choi Hyong Woo , Yeam Inhwa , Lee Je Min , Kim Yonggyun
Published: October 2021

Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect homolog of HMGB1. In this study, a DSP1 (Se-DSP1) encoded in Spodoptera exigua, a phytophagous insect, was characterized, and its potential role in immune response was explored. Upon bacterial challenge, Se-DSP1 was localized in the nucleus and released into the hemolymph. The released Se-DSP1 could mediate both cellular and humoral immune responses by activating eicosanoid biosynthesis. Salicylic acid could bind to Se-DSP1 with a high affinity. The immune responses of S. exigua were significantly interrupted by SA feeding. Larvae reared on tomatoes with high endogenous SA levels became more susceptible to entomopathogens. Taken together, these results suggest a tritrophic defensive role of plant SA against phytophagous insects.
Probing Light-Dependent Regulation of the Calvin Cycle Using a Multi-Omics Approach
Authors: Yu King Hing Nathaphon , Aryal Uma K. , Morgan John A.
Published: October 2021

Photoautotrophic microorganisms are increasingly explored for the conversion of atmospheric carbon dioxide into biomass and valuable products. The Calvin-Benson-Bassham (CBB) cycle is the primary metabolic pathway for net CO2 fixation within oxygenic photosynthetic organisms. The cyanobacteria, Synechocystis sp. PCC 6803, is a model organism for the study of photosynthesis and a platform for many metabolic engineering efforts. The CBB cycle is regulated by complex mechanisms including enzymatic abundance, intracellular metabolite concentrations, energetic cofactors and post-translational enzymatic modifications that depend on the external conditions such as the intensity and quality of light. However, the extent to which each of these mechanisms play a role under different light intensities remains unclear. In this work, we conducted non-targeted proteomics in tandem with isotopically non-stationary metabolic flux analysis (INST-MFA) at four different light intensities to determine the extent to which fluxes within the CBB cycle are controlled by enzymatic abundance. The correlation between specific enzyme abundances and their corresponding reaction fluxes is examined, revealing several enzymes with uncorrelated enzyme abundance and their corresponding flux, suggesting flux regulation by mechanisms other than enzyme abundance. Additionally, the kinetics of 13C labeling of CBB cycle intermediates and estimated inactive pool sizes varied significantly as a function of light intensity suggesting the presence of metabolite channeling, an additional method of flux regulation. These results highlight the importance of the diverse methods of regulation of CBB enzyme activity as a function of light intensity, and highlights the importance of considering these effects in future kinetic models.
Evaluation of Mental Load of Drivers in Long Highway Tunnel Based on Electroencephalograph
Authors: Yang Yanqun , Feng Yang , Easa Said M. , Zheng Xinyi
Published: October 2021

In recent years, the mileage of the tunnels has substantially increased with the rapid highway construction that led to increasing highway tunnels. Most studies on tunnel accidents have mainly focused on the external environments, such as tunnel structure, traffic volume, and lighting. In addition, although many studies on mental load of drivers have been conducted for public roads, such studies for highway tunnels have been limited. In this study, three scenarios with different front vehicle speeds (60, 45, and 30 km/h) in a two-lane long tunnel (one lane in each travel direction) were evaluated using a driving simulator. The experiment involved 24 participants (14 men and 10 women) with an average age of 25.8 years and an average experience of 3.2 years. The electroencephalogram (EEG) technology was used to collect the leading EEG indicators during the driving simulation of the scenarios: α, β, and θ waves and the wave ratio, (α + θ)/β. According to the β-wave energy measurements, the alertness of drivers was the lowest at 45 km/h after adapting to the tunnel environment, indicating that the drivers were more comfortable at this speed. This preliminary finding should help in determining the speed limit in this type of tunnel.
Design Training and Creativity: Students Develop Stronger Divergent but Not Convergent Thinking
Authors: Xia Tiansheng , Kang Mengxia , Chen Meng , Ouyang Jia , Hu Fei
Published: October 2021

Design training programs that teach creativity often emphasize divergent thinking (generation of ideas) more than convergent thinking (evaluation of ideas). We hypothesized that training would lead to more both types of creativity, but especially divergent thinking. Three groups of university students (N=120;n=40 in each group) were recruited to participate: senior design students (graduate students with at least 4years of design training as undergraduates); junior design students (undergraduates in their first year of design training); and undergraduate students in majors unrelated to design. The students completed three tasks in a classroom setting to assess divergent thinking (Alternate Uses Task), convergent thinking (Remote Associates Task), and nonverbal abstract reasoning (Raven’s Progressive Matrices Test). The results of one-way ANOVAs showed that as expected, senior design students significantly outperformed junior design students and non-design majors in divergent thinking. However, contrary to expectations, senior design students had significantly lower scores than the non-design group on convergent thinking; the junior design students’ scores fell in the middle but were not significantly different from either of the other groups. There were no group differences in nonverbal abstract reasoning. These findings suggest that design training significantly improves students’ ability to generate ideas but does not improve, or may even hinder, their ability to evaluate whether the ideas are useful for the task at hand. The results have implications for developing a research-based curriculum in design training programs.
The Positive Side of Maximization: Linking Maximization Tendency With Meaning in Life Through Time Perspectives
Authors: Ma Min , Zhao Na , Zhang Li
Published: October 2021

The negative influence of maximization on well-being, that is, the maximization paradox, has received increased attention. However, few studies have shown the link between maximization tendency and meaning in life, which is one type of well-being, and no empirical literature has examined the mechanisms between them. We conducted an online survey in China to test the relationship between maximization tendency and meaning in life. Participants (N=2,987) were invited to report their maximization, time perspective, meaning in life, and other control variables and demographic variables. Multi-mediation path analysis was adopted in the data analysis. The results revealed that maximization was positively associated with meaning in life, which confirmed the positive aspect of the maximization tendency. Further analyses indicated that the time perspectives of past-positive and future mediated the positive relationship between maximization and meaning in life. In contrast, a present-fatalistic time perspective was a suppressor in the positive relationship. Our findings suggest that the maximization tendency has a positive aspect rather than the overall maximization paradox. An important means of elevating meaning in life is to encourage the time perspective of past-positive and future-oriented and reduce the present-fatalistic time perspective.
Does Implicit Self-Reference Effect Occur by the Instantaneous Own-Name?
Authors: Yaoi Ken , Osaka Mariko , Osaka Naoyuki
Published: October 2021

Self-reference effect (SRE) is defined as better recall or recognition performance when the materials that are memorized refer to the self. The SRE paradigm usually requires participants to explicitly refer items to themselves, but some researchers have found that the SRE also can occur for implicitly self-referenced items. Few studies though have investigated the effect of self-related stimuli without awareness. In this study, we presented self-related (participants’ names) or other (other’s names or nouns) stimuli for a very short time between masks and then explicitly presented subsequent trait adjectives to participants. Recognition performance showed no significant differences between the own-name and the other two conditions in Experiment 1 that had random-order conditions. On the other hand, the result of Experiment 2 that had block-order conditions and greater prime stimuli suggests that SRE can occur as a result of the instantaneous stimulus: Subjects who showed better memory performance also had relatively high recognition of the trait adjectives that they viewed after their instantaneously presented own-name. This effect would show that self-representation can be activated by self-related stimuli without awareness and that subsequent items are unconsciously referenced to that self-representation.
The Emotional Effect of Background Music on Selective Attention of Adults
Authors: Nadon Éva , Tillmann Barbara , Saj Arnaud , Gosselin Nathalie
Published: October 2021

Daily activities can often be performed while listening to music, which could influence the ability to select relevant stimuli while ignoring distractors. Previous studies have established that the level of arousal of music (e.g., relaxing/stimulating) has the ability to modulate mood and affect the performance of cognitive tasks. The aim of this research was to explore the effect of relaxing and stimulating background music on selective attention. To this aim, 46 healthy adults performed a Stroop-type task in five different sound environments: relaxing music, stimulating music, relaxing music-matched noise, stimulating music-matched noise, and silence. Results showed that response times for incongruent and congruent trials as well as the Stroop interference effect were similar across conditions. Interestingly, results revealed a decreased error rate for congruent trials in the relaxing music condition as compared to the relaxing music-matched noise condition, and a similar tendency between relaxing music and stimulating music-matched noise. Taken together, the absence of difference between background music and silence conditions suggest that they have similar effects on adult’s selective attention capacities, while noise seems to have a detrimental impact, particularly when the task is easier cognitively. In conclusion, the type of sound stimulation in the environment seems to be a factor that can affect cognitive tasks performance.
Comparing the Self-Reported Personality Disorder Traits and Childhood Traumatic Experiences Between Patients With Schizophrenia Vs. Major Depressive Disorder
Authors: Zhao Nan , Shi Dianhong , Huang Juan , Chen Qiuying , Wang Qiang
Published: October 2021

Introduction: Personality disorder (PD) and childhood traumatic experience (CTE) are well- recognized risk factors for the development of schizophrenia (SZ) and major depressive disorder (MDD). The relationship between CTE and PD is extremely close, and both conditions can affect subsequent psychiatric disorders. Little is known about the differences of these factors in patients with SZ and those with MDD.

Materials and Methods: A total of 1,026 outpatients participated in the study, including 533 (51.9%) with SZ and 493 (48.1%) with MDD who were sequentially sampled. The PD traits were assessed using the Personality Diagnostic Questionnaire Fourth Edition Plus (PDQ-4+). The Child Trauma Questionnaire Short Form (CTQ-SF) was used to assess childhood adversities. The scores and associations of PDQ-4+ and CTQ-SF between patients with SZ and those with MDD were compared.

Results: The MDD group exhibited more PD traits and more childhood emotional neglect than the SZ group. In patients with MDD, the correlation between PD traits and CTE was significantly higher than that in patients with SZ. Patients with SZ vs. those with MDD showed different PD traits and CTE. The schizotypal and antisocial PD traits, as well as sexual abuse and physical neglect CTE, were significantly related to SZ. In contrast, the borderline, narcissistic and avoidant PD traits, and emotional abuse/neglect CTE were significantly associated with MDD.

Discussion: These findings indicated a robust relationship between CTE and PD traits. Moreover, patients with SZ or MDD, have different interactive patterns. Both CTE and PD traits have the potential to be premorbid risk factors that could be targeted for preventative interventions.
Cardiovascular Risk Awareness and Calculated 10-Year Risk Among Female Employees at Taibah University 2019
Authors: Qasem Surrati Amal M. , Mohammedsaeed Walaa , Shikieri Ahlam B. El
Published: October 2021

Cardiovascular diseases (CVD) are the most common cause of death and disability worldwide. Saudi Arabia, one of the middle-income countries has a proportional CVD mortality rate of 37%. Knowledge about CVD and its modifiable risk factors is a vital pre-requisite to change the health attitudes, behaviors, and lifestyle practices of individuals. Therefore, we intended to assess the employee knowledge about risk of CVD, symptoms of heart attacks, and stroke, and to calculate their future 10-years CVD risk. An epidemiological, cross-sectional, community-facility based study was conducted. The women aged ≥40 years who are employees of Taibah University, Al-Madinah Al-Munawarah were recruited. A screening self-administrative questionnaire was distributed to the women to exclude those who are not eligible. In total, 222 women met the inclusion criteria and were invited for the next step for the determination of CVD risk factors by using WHO STEPS questionnaire: It is used for the surveillance of non-communicable disease risk factor, such as CVD. In addition, the anthropometric measurements and biochemical measurements were done. Based on the identified atherosclerotic cardiovascular disease (ASCVD) risk factors and laboratory testing results, risk calculated used the Framingham Study Cardiovascular Disease (10-year) Risk Assessment. Data were analyzed using GraphPad Prism 7 software (GraphPad Software, CA, USA). The result showed the mean age of study sample was 55.6 ± 9.0 years. There was elevated percentage of obesity and rise in abdominal circumference among the women. Hypertension (HTN) was a considerable chronic disease among the participants where more than half of the sample had it, i.e., 53%. According to the ASCVD risk estimator, the study participants were distributed into four groups: 63.1% at low risk, 20.2% at borderline risk, 13.5% at intermediate risk, and 3.2% at high risk. A comparison between these categories based on the CVD 10-year risk estimator indicated that there were significant variations between the low-risk group and the intermediate and high-risk groups (P = 0.02 and P = 0.001, respectively). The multivariate analysis detected factors related to CVD risk for women who have an intermediate or high risk of CVD, such as age, smoking, body mass index (BMI), unhealthy diet, blood pressure (BP) measurements, and family history of CVD (P < 0.05). The present study reports limited knowledge and awareness of CVD was 8.6 that is considered as low knowledge. In conclusion, the present study among the university sample in Madinah reported limited knowledge and awareness of CVD risk. These findings support the need for an educational program to enhance the awareness of risk factors and prevention of CVD.
Recurrent Neural Network and Reinforcement Learning Model for COVID-19 Prediction
Authors: Kumar R. Lakshmana , Khan Firoz , Din Sadia , Band Shahab S. , Mosavi Amir , Ibeke Ebuka
Published: October 2021

Detection and prediction of the novel Coronavirus present new challenges for the medical research community due to its widespread across the globe. Methods driven by Artificial Intelligence can help predict specific parameters, hazards, and outcomes of such a pandemic. Recently, deep learning-based approaches have proven a novel opportunity to determine various difficulties in prediction. In this work, two learning algorithms, namely deep learning and reinforcement learning, were developed to forecast COVID-19. This article constructs a model using Recurrent Neural Networks (RNN), particularly the Modified Long Short-Term Memory (MLSTM) model, to forecast the count of newly affected individuals, losses, and cures in the following few days. This study also suggests deep learning reinforcement to optimize COVID-19's predictive outcome based on symptoms. Real-world data was utilized to analyze the success of the suggested system. The findings show that the established approach promises prognosticating outcomes concerning the current COVID-19 pandemic and outperformed the Long Short-Term Memory (LSTM) model and the Machine Learning model, Logistic Regresion (LR) in terms of error rate.
Solving the Large-Scale TSP Problem in 1 h: Santa Claus Challenge 2020
Authors: Mariescu-Istodor Radu , Fränti Pasi
Published: October 2021

The scalability of traveling salesperson problem (TSP) algorithms for handling large-scale problem instances has been an open problem for a long time. We arranged a so-called Santa Claus challenge and invited people to submit their algorithms to solve a TSP problem instance that is larger than 1 M nodes given only 1 h of computing time. In this article, we analyze the results and show which design choices are decisive in providing the best solution to the problem with the given constraints. There were three valid submissions, all based on local search, including k-opt up to k = 5. The most important design choice turned out to be the localization of the operator using a neighborhood graph. The divide-and-merge strategy suffers a 2% loss of quality. However, via parallelization, the result can be obtained within less than 2 min, which can make a key difference in real-life applications.
Previous Extrapulmonary Malignancies Impact Outcomes in Patients With Surgically Resected Lung Cancer
Authors: Lee Hsin-Ying , Hsieh Min-Shu , Liao Hsien-Chi , Chen Pei-Hsing , Chiang Xu-Heng , Tsou Kuan-Chuan , Tsai Tung-Ming , Chuang Jen-Hao , Lin Mong-Wei , Hsu Hsao-Hsun , Chen Jin-Shing
Published: October 2021

Background: As the overall survival of patients with cancer continues to improve, the incidence of second primary malignancies seems to be increasing. Previous studies have shown controversial results regarding the survival of patients with primary lung cancer with previous extrapulmonary malignancies. This study aimed to determine the clinical picture and outcomes of this particular subgroup of patients.

Materials and Methods: We included 2,408 patients who underwent pulmonary resection for primary lung cancer at our institute between January 1, 2011 and December 30, 2017 in this retrospective study. Medical records were extracted and clinicopathological parameters and postoperative prognoses were compared between patients with lung cancer with and without previous extrapulmonary malignancies.

Results: There were 200 (8.3%) patients with previous extrapulmonary malignancies. Breast cancer (30.5%), gastrointestinal cancer (17%), and thyroid cancer (9%) were the most common previous extrapulmonary malignancies. Age, sex, a family history of lung cancer, and preoperative carcinoembryonic antigen levels were significantly different between the two groups. Patients with previous breast or thyroid cancer had significantly better overall survival than those without previous malignancies. Conversely, patients with other previous extrapulmonary malignancies had significantly poorer overall survival (p < 0.001). The interval between the two cancer diagnoses did not significantly correlate with clinical outcome.

Conclusion: Although overall survival was lower in patients with previous extrapulmonary malignancies, previous breast or thyroid cancer did not increase mortality. Our findings may help surgeons to predict prognosis in this subgroup of patients with primary lung cancer.
Benefit of Bovine Viral Diarrhoea (BVD) Eradication in Cattle on Pestivirus Seroprevalence in Sheep
Authors: Huser Andrea Franziska , Schär Jessica Grace , Bachofen Claudia , de Martin Elena , Portmann Jasmine , Stalder Hanspeter , Schweizer Matthias
Published: October 2021

Bovine viral diarrhoea virus (BVDV) and Border disease virus (BDV) are closely related pestiviruses of cattle and sheep, respectively. Both viruses may be transmitted between either species, but control programs are restricted to BVDV in cattle. In 2008, a program to eradicate bovine viral diarrhoea (BVD) in cattle was started in Switzerland. As vaccination is prohibited, the cattle population is now widely naïve to pestivirus infections. In a recent study, we determined that nearly 10% of cattle are positive for antibodies to BDV. Here, we show that despite this regular transmission of BDV from small ruminants to cattle, we could only identify 25 cattle that were persistently infected with BDV during the last 12 years of the eradication program. In addition, by determining the BVDV and BDV seroprevalence in sheep in Central Switzerland before and after the start of the eradication, we provide evidence that BVDV is transmitted from cattle to sheep, and that the BVDV seroprevalence in sheep significantly decreased after its eradication in cattle. While BDV remains endemic in sheep, the population thus profited at least partially from BVD eradication in cattle. Importantly, on a national level, BVD eradication does not appear to be generally derailed by the presence of pestiviruses in sheep. However, with every single virus-positive cow, it is necessary to consider small ruminants as a potential source of infection, resulting in costly but essential investigations in the final stages of the eradication program.
Biological Control of Plant Diseases in Changing Environment
Authors: Dubey Mukesh
Published: October 2021

Excessive pesticide application for plant disease control can result in environmental and health-related problems [...]
Effects of Corn Stalks and Urea on N2O Production from Corn Field Soil
Authors: Wu Kaikuo , Zhang Zhe , Feng Liangshan , Bai Wei , Feng Chen , Song Yuchao , Gong Ping , Meng Yue , Zhang Lili
Published: October 2021

Returning corn stalks to the field is an important and widely used soil management practice which is conducive to the sustainable development of agriculture. In this study, the effects of corn stalks and urea on N2O production in corn field soil were investigated through a 21-day incubation experiment. This study showed that increasing amounts of urea added to soil with a history of corn cultivation leads to increasing overall N2O emissions, by increasing both the intensity and the duration of emissions. Although N2O production was affected primarily by urea-derived NH4+-N and NO3−-N, its main source was native soil nitrogen, which accounted for 78.5 to 94.5% of N2O. Returning corn stalk residue to the field reduced the production of N2O, and the more urea was applied, the stronger the effect of corn residue on reducing N2O emissions. Combining the application of corn stalks and urea could reduce the concentration of NH4+-N and NO3−-N derived from urea, and then reduce the substrate required for N2O production in nitrification and denitrification processes. In addition, the combined application of corn stalks and urea could effectively inhibit the abundance of key N2O-producing genes AOA amoA, nirS and nirK.
Identification of Thermophilic Aerobic Sporeformers in Bedding Material of Compost-Bedded Dairy Cows Using Microbial and Molecular Methods
Authors: Giambra Isabella J. , Jahan Yeasmin , Yin Tong , Engel Petra , Weimann Christina , Brügemann Kerstin , König Sven
Published: October 2021

Compost-bedded pack barns (CBP) are of increasing interest in dairy farming due to their positive effect on animal welfare. The temperature and the moisture content of the bedding material characterising the composting process can promote the growth of thermophilic aerobic sporeformers (TAS). Therefore, the aim of this study was to determine CBP bedding material characteristics, such as moisture content and temperature, and to determine TAS species. The dilution, the heat inactivation of all non-TAS species and the incubation of 13 bedding samples from four CBP groups resulted in a mean TAS amount over all samples of 4.11 log10 cfu/g bedding material. Based on the subsequent sequencing of parts of the 16S rRNA-gene of 99 TAS colonies, the TAS species Aneurinibacillus thermoaerophilus, Bacillus licheniformis, Geobacillus thermodenitrificans, Laceyella sacchari, Thermoactinomyces vulgaris and Ureibacillus thermosphaericus were identified. The moisture content of the bedding material, the relative humidity above the bedding material and the sampling season significantly affected the amount of TAS. The moisture content or relative humidity above the bedding material significantly influenced the concentration of Ureibacillus thermophaericus or Laceyella sacchari. Consequently, an optimal CBP management including a dry lying surface and an optimal composting process will contribute to a moderate microbial, especially TAS amount, and TAS species distribution.
Research on the Organic Binders in Archaeological Wall Paintings
Authors: Casoli Antonella
Published: October 2021

Wall painting realized using organic binders is the oldest form of parietal painting and precedes the birth of the affresco by about 20,000 years. This paper reports the results obtained from the main studies in the field of archaeological wall paintings. The attention was paid to the study of organic binders used for the application of the color, as well as on the instrumental techniques chosen to obtain such information. Different techniques can be used for the study of organic material in archeological paintings: non-destructive techniques, which can be applied directly in situ without sampling, and laboratory micro-invasive techniques for a more in-depth characterization. Among these, the chromatographic techniques represent a potential tool to acquire as much information as possible about chemical composition of binders.