bluuebunny/crossref_metadata_2025 huggingface dataset:
Tuboovarian Abscess Treatment Outcomes at an Academic Safety Net Hospital in Los Angeles, California
Authors: Lee Samantha Guinevere , Novatt Hilary , Sripras Intira , Nguyen Brian T.
Published: March 2022

Purpose: To identify patient factors associated with medical management failure and hospital readmission among patients admitted with a diagnosis of tuboovarian abscess at a public hospital in Los Angeles, California. Methods: We conducted a retrospective chart review of admissions for tuboovarian abscess from January 2014 through August 2019, describing treatment plans and their subsequent outcomes. Patient factors associated with failure of medical management, as defined by requiring image-guided drainage or surgery, and hospital readmission were identified via bivariate analyses, using Chi-square, Fisher’s exact, and Wilcoxon signed-rank tests as appropriate. Factors independently linked to failure of medical management were determined via logistic regression. Results: We treated 147 patients with tuboovarian abscess over 5 years, comprised primarily of Hispanic/Latinx (74%; n=109/147) women, median age 39 (range: 18-70) years. The median abscess size was 6.3cm (range: 4.8-8.0). Only 16% (n=23/147) who initially received parenteral antibiotic therapy failed medical management. Factors independently and positively linked to parenteral antibiotic failure included elevated white blood cell count (aOR 1.17; 95%CI 1.04-1.32) and abscess size (aOR 1.07; 95%CI 1.04-1.10). No tuboovarian abscesses under 5.5 centimeters required procedural intervention when treated with parenteral antibiotics alone. We identified rehospitalizations among 13.6% (n=20/147) of patients; no factors were significantly linked to rehospitalization.Conclusions: Tuboovarian abscesses were successfully treated with medical management in more than 80% of cases. Early procedural intervention for tuboovarian abscesses greater than 5.5 centimeters in diameter may help to avoid short and long-term morbidities.
Comparing Molecular Biomarker Testing With Immunohistochemical Staining In Predicting Response To Neoadjuvant Therapy In Breast Cancer
Authors: Behairy Mahmoud Abdel-Ghany , Gabal Samia Mohmed , Metenawy Wafaa Hasan El , Kasem Loay Mohamed , Abel-Salam Lubna omar
Published: March 2022

Background: Breast cancer (BC) is the most common cancer type among women world-wide and the major cause of cancer deaths. Many factors affect the prognosis and treatment of BC such as histological grading, staging, as well as the biological markers: Estrogen receptor (ER), Progesterone receptor (PR), HER2 and Ki67. Immunohistochemistry (IHC) remains the corner stone in determining ER, PR, HER2 and Ki67 status for breast cancers, however limitations still exist concerning analytic validity & interpretation. mRNA expression assays can provide an alternative innovative method for measuring these biomarkers. The Xpert Breast Cancer STRAT4 Assay is an in vitro diagnostic test for the determination of overexpression or non-overexpression of ER, PR, HER2 and Ki67 mRNA isolated from 10% neutral buffered FFPE invasive breast tissue.Objectives: Comparing results (concordance) of IHC of ER, PR, Ki67 and Her2 with mRNA gene expression analysis results by STRAT4 for each of the biomarkers tested on the same sample blocks & correlating the results of IHC with the clinico-pathologic parameters of the tumours and clinical outcome of patients. Materials and methods: One hundred BC tissue sections were collected from needle biopsies specimens & were evaluated for expression of the four biomarkers (ER, PR, KI67, Her-2) using IHC and the same blocks were sectioned and tested for mRNA gene expression by the Xpert breast cancer STRAT4 for the same markers. Results: Concordance rate between mRNA expression and IHC was 96% for ER, 94.7% for PR, 93% for HER-2, 97.9% for Ki67, with Kappa measurement showing strong to perfect agreement in the 4 parameters (all > 80%).Conclusion: The study reveals high concordance between central IHC and mRNA measurements of the four main breast cancer biomarkers. STRAT4 can provide an effective modality for standardized results for breast cancer patients.
Padua Prediction Score was Inappropriate for Venous Thromboembolism Risk Assessment in Acute Medical Inpatients: A Cohort Study
Authors: Yang Suqiao , Zhang Yixiao , Jiao Xiaojing , Liu Jiayu , Wang Wei , Kuang Tuguang , Gong Juanni , Li Jifeng , Yang Yuanhua
Published: March 2022

Background
Padua Prediction Score (PPS) still lacks of effectively external validation in Chinese population. To assess the accuracy of PPS to predict venous thromboembolism (VTE) risk in acute medical inpatients, and to compare the predictive value with Caprini risk assessment model (RAM).
Methods
This consecutive cohort study included acute internal medicine inpatients in Beijing Institute of Respiratory Medicine, Beijing, China from January to August 2019. The PPS and Caprini RAM were assessed for all the patients. The occurrence rate of VTE predicted by PPS and Caprini RAM was compared using Chi-squared test. Discrimination was evaluated by the area under curve using the Delong tests. Reclassification parameters were also used to compare the PPS's clinical utility with that of the Caprini RAM.
Results:
A total of 1647 inpatients of internal medicine were retrospectively registered. The overall incidence of VTE during hospitalization was 13.2%. The incidence of VTE in low-risk patients was 6.5% assessed by PPS, which was significantly higher than that by Caprini RAM (2.6%, p < 0.001). The area under the receiver operating characteristic curve (ROC) for PPS and Caprini RAM was 0.747 (95%CI, 0.725–0.768) and 0.773 (95%CI, 0.752–0.793), respectively (p = 0.0453). Based on the best cut-off, the specificity of the PPS appeared higher than that of the Caprini RAM (82.45 vs 60.07, p < 0.001), but its sensitivity was lower (59.45 vs 83.87, p < 0.001). Compared with Caprini RAM, the net reclassification index was estimated at 0.094 (p = 0.016) and integrated discrimination improvement was 0.037 (p = 0.098) by PPS. The ROC curve of the Caprini RAM and PPS in the subgroup of patients without pharmacological prophylaxis during their hospitalization was 0.776 of the Caprini RAM, which was significantly higher than that of the PPS (p = 0.005).
Conclusions
PPS seems inappropriately to predict VTE risk in acute internal medicine inpatients. It has limitations not only in the performance of identifying “VTE high-risk” patients, but also in the ability of discrimination. An accurate, widely applicable, validated RAM for prediction of the VTE risk needs to be further constructed in Chinese hospitalized medical patients.
A hierarchical spatial Durbin model (HSDM): An application to regional production efficiency in Europe
Authors: Márquez Alejandro Almeida , Hernández Julián Ramajo
Published: March 2022

Expanding the recent spatial econometrics literature on hierarchical models of , this work proposes an extension of the autoregressive spatial hierarchical model (HSAR) to a Durbin spatial hierarchical model (HSDM) that allows taking into account the spillovers produced in the independent variables.For this, the proposed model is estimated to analyze the production function of 263 European regions nested in 28 different countries for years 2000, 2007 and 2014. The results seem to indicate that the proposed model produces results similar to the HSAR model or improves them taking into account the influence that capitaland employment levels may have in other regions. Furthermore, this model allows analyzing the process of regional and national spillovers and, country influence on the regions.
Expression of mRNAs for DNA-methyltransferases and Histone Deacetylases in Granulosa Cells and Follicular Fluid of Women Undergoing in vitro Fertilization
Authors: Farkas Balint , Szalai Sarolta , Bódis Jozsef , Varjas Timea , Varnagy Akos , Godony Krisztina , Szenczi Agnes , Sulyok Endre
Published: March 2022

Background: Gene products involved in reproduction frequently undergo post-transcriptional modifications by DNA methylation and histone acetylation. The aim was to assess the predictive value of gene expression levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in patients treated with in vitro fertilization (IVF). In a prospective, l clinical study 31 consecutive patients with male (n=17) or female (n=14) infertility diagnoses were enrolled. Granulosa cells (GCs) and follicular fluid (FF) were obtained at the oocytes retrieval during IVF. mRNA levels of DNMT1, DNMT3a, DNMT3b and HDAC5, HDAC6 were measured in GCs and FF by quantitative RT-PCR using ROCHE Lightcycler 480. The outcome measures were the number of oocytes retrieved, mature oocytes and viable embryos, as well as chemical and clinical pregnancy.Results: It was demonstrated that genes for DNMTs and HDACs could be detected in nearly equal amount in GC and FF, however, only the DNMT3a transcript in FF correlated with that in GC (r=0.478, p<0.033). Moreover, FF DNMT3a was significantly higher in the pregnant (N=9) than in the non-pregnant (N=22) patients (p<0.016), and HDAC6 in GC was significantly related to the number of oocytes retrieved (r=0.413, p<0.026), MII oocytes (r= 0.383, p<0.040) and viable embryos (r=0.413, p<0.025).Conclusions: In our clinical setting the expression of mRNA for FF DNMT3a and for GC HDAC6 has the potential to assess IVF outcome.
Dexmedetomidine Attenuates Hyperalgesia Induced By Brachial Plexus Root Avulsion By Restoring The GLT-1 Function Via PKA Signaling
Authors: Xu Xiaoying , Ren Zhiheng , Tang Ying , Zilundu Prince L. M. , Zhou Yingying , Li Wenfu , Hou Jiawei , Fu Yixin , Mai Yunlin , Huang Yu , Liaquats Zaara , Cheng Xiao , Ye Jiang-Hong , Zhou Li-Hua , Fu Rao
Published: March 2022

Background: Chronic neuropathic pain often occurs with unclear mechanisms after brachial plexus root avulsion (BPRA) injuries. Emerging evidence suggests that the maladaptation of spinal glial glutamate transporter GLT-1 causes extracellular glutamate accumulation, contributing to central sensitization of chronic pain. Dexmedetomidine (DMET), an α2-adrenergic receptor (α2AR) agonist, widely used in the clinic as a sedative and analgesic drug, has been shown to inhibit glial activation. This study assessed DMET effects on BPRA induced pain and the possible involvement of GLT-1 regulation. Methods: The right C8 and T1 roots were avulsed to establish a lower trunk BPRA injury rat model and LPS-induced activation of rat primary cultured astrocytes. Then we used the molecular and behavioral assay combined with pharmacological manipulation to test the hypothesis that DMET attenuates the pain and neuroinflammation through restoring the GLT-1 function via PKA signaling.Results: The mechanical allodynia and thermal hyperalgesia appeared and reached the peak at 1-day post-injury (dpi) and persisted for at least 28 dpi. Notably, BPRA enhanced phosphorylated PKA levels, reduced GLT-1 expression, and caused an imbalance between anti- and proinflammatory cytokines in the affected spinal segments. Acute systemic or local DMET administration, at the un-sedative doses, demonstrated an analgesic effect. Moreover, a 3-days intrathecal DMET treatment ameliorated hyperalgesia and allodynia of BPRA injured rats by attenuating PKA phosphorylation, IL-1β, and IL-6, while restoring the levels of GLT-1, IL-4, and IL-10 in the spinal cord. Significantly, intrathecal administration of the selective PKA inhibitor H89 mimicked, but the PKA activator 8-Br-cAMP blocked DMET’s effects. Conclusion: Overall, these results suggest that PKA inactivation mediates DMET's analgesic effect for the pain induced by BPRA injury through the recovery of GLT-1 function.
Analysis of complex chromosomal rearrangements using a combination of current molecular cytogenetic techniques
Authors: He Ping , Wei Xiaoni , Xu Yuchan , Huang Jun , Tang Ning , Yan Tizhen , Yang Chuanchun , Lu Kangmo
Published: March 2022

Background
Using combined fluorescence in situ hybridization (FISH) and high-throughput whole genome sequencing (WGS) molecular cytogenetic technology, we aim to analyze the junction breakpoints of complex chromosome rearrangements (CCR) that were difficult to identify by conventional karyotyping analysis and further characterize the genetic causes of recurrent spontaneous abortion.
Results
By leveraging a combination of current molecular techniques including chromosome karyotype analysis, FISH and WGS, we were able to fully characterize the extremely complex chromosomal abnormalities in this patient with recurrent spontaneous abortions. Here, we demonstrated that combining these current established molecular techniques is an effective and efficient workflow to identify the structural abnormalities of complex chromosomes and locate the rearrangement of DNA fragments.
Conclusions
In conclusion, leveraging results from multiple molecular and cytogenetic techniques can provide the most comprehensive genetic analysis for genetic etiology research, genetic diagnosis and genetic counseling for patients with recurrent spontaneous abortion and embryonic abortion.
Surveillance of Russell Body Inflammation of the Digestive Tract: A Case Report and Review of Literature
Authors: Luo Shuai , Huang Xiang , Li Yao , Wang Jinjing
Published: March 2022

Introduction: Russell body inflammation of the digestive tract (RBIDT) is a rare chronic inflammation of the digestive tract mucosa that commonly presents as Russell body gastritis (RBG). This disease is usually associated with Helicobacter pylori (HP) infection. However, it can also occur in individuals without HP infection and with specific immune profiles, as seen in HIV and hepatitis C infections. The aetiology and pathogenesis of this disease remain controversial. Given the rarity of the disease and the diversity of the immunophenotypes, there is a high probability of misdiagnosis.Case Presentation: A male patient with RBG and HP infection was included in this study. The case of RBG with an unusual morphology of Mott cells that mimics stamped ring cells.Endoscopy performed during the follow-up revealed regression of the lesion 1 week after anti-HP treatment.Conclusion: A case of RBG with a high likelihood of misdiagnosis of signet ring cell carcinoma (SRC) has been reported in this study along with a review of the relevant literature and an overview of RBIDT.
Topdressing N fertilization on productivity and nutritional status of common bean crop
Authors: Clemente Junia Maria , Coser Thais Rodrigues , Sales Harley , Fariña Pedro Ruben Viera , Aquino Leonardo Angelo de
Published: March 2022

The present study aimed to compare sources and doses of N on productivity, nutritional status and commercial quality of bean (Phaseolus vulgaris) crop. The treatments consisted of the following N doses: 60, 90 and 110 kg N/ha. The sources were YaraLiva Nitrabor (390, 585 and 715 kg ha-1) and Urea (130, 195 and 240 kg ha-1). Both sources and doses were applied before or after 15 mm irrigation. In case of fertilizers application after 15 mm irrigation, 1 mm of water was applied after application only to lightly soak granules, which was called “drizzle”, simulating a low-intensity rain after fertilizer application. The experiment was designed as randomized block with four replications in a factorial scheme (2x3x2) + 1, during 113 days with sowing on 06/25/2018 and harvest on 10/18/2018. BRS Estilo was the cultivar used in this study. Application of calcium nitrate in moist soil followed by drizzle provide gains around 5.48 kg of bean per kg of topdressing N, while urea provides gains of 2.22 kg of bean per kg of topdressing N
Genetic variability, heritability and genetic advance of soybean (Glycine max)
genotypes based on yield and yield-related traits
Authors: Mofokeng Maletsema Alina
Published: March 2022

The success of breeding programme relies on the variability present in the breeding material. Selection is also effective when there is significant amount of genetic variability among the individuals in a population. The study aimed at assessing genetic variability, heritability and genetic advance among yield and yield components of soybean genotypes. Eighty-two genotypes maintained at the Agricultural Research Council-Grain Crops were planted in an alpha lattice design, replicated twice in Potchefstroom and Brits in South Africa in 2017/18 growing season. Five plants per genotype were selected and yield and yield related traits were measured. Data were analysed through analysis of variance and genetic parameters were estimated. The results showed highly significant differences among the genotypes based on days to flowering, branch number per plant, hundred seed weight, pod weight per plant, pod length, seed number per plant, seed number per pod and grain yield. Heritability of yield and yield components were ranged from 5.9% to 100%. The most heritable traits were hundred seed weight (100 %), days to flowering (64.13 %) and seed number per pod (67.37%). The genotypic variance ranged from 0.3% to 33% while the phenotypic variation ranged from 1.5% to 44%. The phenotypic and genotypic coefficient of variations was high for grain yield, medium for days to flowering and lowest for hundred seed weight. The phenotypic coefficient of variations (PCV) was higher than genotypic coefficient of variation (GCV) for all characters indicating the influence of environmental factors. The expected genetic advance was high for most of the traits, medium for seed number per pod and hundred seed weight and low for pod number per plant. The expected genetic advance as percent of mean was variable and high for all traits. There was vast variation observed among the soybean genotypes evaluated based on the yield and yield related traits
Plant growth promoting rhizobacteria enhance the ratoon productivity of sugarcane
Authors: Lonhienne Chanyarat Paungfoo- , Watanarojanaporn Nantida , Petersen Ian , Jaemsaeng Ratchaniwan , ard Peeraya Klomsa- , Sriroth Klanarong
Published: March 2022

Less than half of the applied chemical fertiliser in intensive cropping systems is utilised by the target crops, with the remaining nutrients contributing to environmental pollution. Reducing the pollution derived from inefficient use of chemical fertilisers has enormous importance for agriculture. Recently, studies have shown that plant growth promoting rhizobacteria (PGPR) Paraburkholderia sp. SOS3 along with a combination of organic and chemical fertilisers, can offer a viable avenue to enhance sugarcane growth while reducing the concentration of chemical fertilisers. Here, we further investigated the effects of adding PGPR with combined organic and chemical fertilisers on sugarcane ratoon productivity (i.e. the second-year ratoon crop). The ratoon crop regenerated from sugarcane fertilised with the chemical-organic fertilisation in the first year, with or without PGPR (4 replicates), was grown in industry-standard practice in the second year. The results show that PGPR inoculation during the initial planting strongly promotes the growth of the ratoon sugarcane in the second year without reapplication of the PGPR. These findings show the high potential of using PGPR along with a combination of organic and chemical fertilisers for improving ratoon crop productivity in sugarcane.
Production of round wood from planted forests and price of pulp and paper and other forestry purposes in southern Brazil
Authors: Oliveira Gustavo Silva , Junior Romano Timofeiczyk , Loper Ailson Augusto , Neto Pedro José Steiner , Alves Ricardo Ribeiro
Published: March 2022

The aim of the study is to analyze the production of round wood from planted forests and the price of pulp and paper and other forestry purposes in southern Brazil, from 2000 to 2019. In this study, we worked with historical series from secondary data collected from the Brazilian Institute of Geography and Statistics IBGE, referring to the produced and traded quantity in forestry (m³), forestry production value (one thousand dollars) and price ($/m³), obtained through the ratio between the production value and the respective produced quantities in each year. The silviculture production value (PV) is a derived variable calculated by the weighted average of quantity and average current price paid to the producer (m³), according to the harvest and commercialization periods of each product. The price evolution (P) was separated according to purpose and obtained through the quotient between the production value and respective quantities produced in each year. The trend models were estimated, in which annual growth rates of the real price and produced quantity were calculated for the two roundwood purposes in the evaluated period. Then, we sought to fit the results according to the possibilities of shift of the supply and demand curves. The results indicate that pulp and paper presented positive rates of produced quantity and price, of 5.8775 and 1.3704, respectively. The nomenclature for other purposes had a positive rate for the produced quantity (4.1929) and a negative rate for price (-0.3203). Thus, logwood for pulp and paper showed a dominant shift in the demand curve to the right, showing a rising market, while for other purposes, there was a dominant shift in supply to the right, corroborating the concept of positive variation in quantity and a negative variation in price. Given these results, it is important to highlight that the study refers to one federative unit in Brazil, which signals the recommendation that other similar studies be carried out in other states to better understand the impact of production and price of these purposes on the Brazilian market
Modification of soybean plant architecture through growth regulators and population variation
Authors: Rosa Willian Pelisser da , Caverzan Andréia , Chavarria Geraldo
Published: March 2022

An important limitation to increased soybean [Glycine max (L.) Merr.] grain yield is excessive plant growth. The use of growth regulators and population adjustment is imperative for the management of soybean. This study aimed to evaluate whether lactofen, used as a growth regulator, and a reduction in plant population affected the architecture of soybean and increased its production efficiency. The study was carried out under field conditions during the 2017–2018 and 2018–2019 seasons. The experimental design was in completely randomised blocks with five treatments and five replications: T1 (control), T2 (application of 140 g a.i. ha−1 of lactofen at phenological stage V3), T3 (application of 140 g a.i. ha−1 of lactofen at phenological stage V6), T4 (plant population 20% lower than recommended) and T5 (plant population 40% lower than recommended). The plant height, the number of nodes, the number of branches, stem diameter, and the internode distance were affected by lactofen application at stage V3. Lactofen use at stage V3 also increased the coverage percentage and the number of droplets per square centimetre of phytosanitary products. The interception of solar radiation was higher with lactofen application at stage V3 and that treatment provided the highest yield. Therefore, the use of lactofen as a growth regulator improves soybean grain yield. A reduction in plant population had the greatest effect on grain number and weight. Plant density should be maintained as recommended to avoid a decrease in grain yield
Do chemical and nutritional compounds change during the storage of Jabuticaba (Plinia cauliflora)?
Authors: Silva Aline Priscilla Gomes da , Spricigo Poliana Cristina , Campos Fernanda Bueno , Oliveira Aline Gomes de , Freitas Thais Pádua de , Jacomino Angelo Pedro
Published: March 2022

Jabuticaba (Plinia cauliflora) is a native Brazilian Atlantic Rainforest fruit tree. Its fruits are purplish berries with a short shelf life, due to fermentative processes that begin shortly after harvest. Recently, commercial jabuticaba exploitation has intensified, justifying the application of postharvest technologies. In this context, this study aimed to evaluate the chemical characteristics and nutraceutical compounds of “ponhema” jabuticabas stored at room and cold temperatures. Chemical analyzes (soluble solids (SS), titratable acidity (TA), pH, soluble sugars, soluble pectins and pectinamethylesterase (PME) activity), and nutraceutical compounds (total anthocyanins (TA), yellow flavonoids (YF), total phenolic compounds (TFC)) were performed. A completely randomized experimental design was applied. Analyzes were performed every 2 days, at days 0, 2, 4 for the room temperature (25° C) assay and at days 0, 2, 4 and 6 for the cold temperature (13° C) experiment. Fruits stored under cold temperature presented lower acetaldehyde and ethanol contents, as well as high soluble sugar, total anthocyanin, and total phenolic compound levels. Fruits stored at room temperature displayed marked wilting and fermentation on the fifth day of storage, preventing their consumption after this period. Fruits presented a shelf-life gain of up to two days when stored at cold temperature, displaying better characteristic maintenance, such as soluble solids, titratable acidity, pH and soluble sugars, which were verified by the acetaldehyde and ethanol tests. Total anthocyanin and phenolic compound levels were higher in fruits stored at cold temperature
Assessment of yield and quality of quinoa accessions grown in Ferralsols following seasonal difference
Authors: Minh Nguyen Van , Nguyen Tinh Van
Published: March 2022

The quinoa accession varieties have been cultivated in Vietnam in recent decades. The initial results indicate that these varieties have well adapted to Vietnam’s climate, even better than some of their mother areas. However, further evaluation of the impact of the seasonal region on quinoa growth and development is necessary for a tropical country like Vietnam. Therefore, this study aimed to analyze the yield and quality of quinoa accession varieties planted on Ferralsolsl in the Dak Lak province of Vietnam in three distinct seasons. Ten quinoa accession varieties include Leucan Boldo, Riobamba, 27 - 6R, EDK – 4, 59 – ALC, ISLUGA, Atlas, Cahuil, Moradas and Haiwan were examined. Field experiments were conducted based on the Randomized Complete Block Design (RCBD) in triplicated repeat. Various plant agronomical traits including plant height, branch number, the total number of the main bunch, length of the bunch, number of grains per bunch, grains weight, as well as the contents of protein, and starch were investigated. Finally, the biological and practical productivity of ten quinoa accessions was determined. In general, the obtained results showed that the quinoa varieties are grown from January to April 2020 (Season 1) had higher quality and yield than those grown in other seasons. Collectively, the variety Atlas showed the highest-quality indexes including agronomical traits such as approximately 37 branches per plant or its bunch length was around 27 cm, and its practical productivity was 22.2 quintals per hectare follow by the Moradas, Cahui, and Haiwan varieties. Taken together, our data indicated that the correlation of the seasonal factor in Dak Lak province of Vietnam is different for each quinoa variety
Compulsory insurance within the framework of the Bank of Russia's Mortgage Regulation Concept
Authors: Жукова О.В.
Published: March 2022

Банком России, во исполнение поручения Президента РФ от 02.04.2020 № Пр-612 о принятии мер по снижению полной стоимости ипотечных жилищных кредитов, одной из составляющих которой являются расходы на страхование, разработана «Концепция регулирования ипотечного страхования». Суть «Концепции» заключается в том, что, после внесения изменений в федеральный закон, страхователем будет выступать не заёмщик-залогодатель, а банк-кредитор выгодопреобретатель или ипотечный агент. Заёмщик должен будет ежемесячно погашать дополнительно 1,0% от суммы кредита в порядке компенсации расходов банка на страхование

The Bank of Russia, pursuant to the instruction of the President of the Russian Federation No. Pr-612 dated 02.04.2020 on taking measures to reduce the full cost of mortgage housing loans, one of the components of which is insurance costs, has developed a «Concept for regulating mortgage insurance», which has been discussed at the level of the professional community, and is currently in the Government of the Russian Federation. The «concept» concerns insurance accompanying the pledge of immovable property arising on the basis of the federal law (mortgage by virtue of the Law) dated 16.07.1998 No. 102-FZ «On Mortgage (pledge of real estate)» and by virtue of the mortgage agreement, as well as personal life and health insurance of the borrower, the essence of which is that, after amendments to the federal law, the policyholder will not be the borrower-mortgagor, but the lender-beneficiary bank or mortgage agent. This is another step towards housing affordability, as the amount of the first lump-sum payment when applying for a mortgage loan and subsequent annual deductions decreases, since the borrower will have to pay insurance premiums in installments for the entire period of the mortgage insurance contract as a percentage, depending on the amount of the mortgage loan.
The use of modern trends in the use of information technologies in improving the efficiency of the agricultural and industrial complex of the north caucasus federal district
Authors: Балиянц К.М. , Дохолян С.В.
Published: March 2022

Цифровое развития АПК региона возможно на основе изучения зарубежного опыта и опыта передовых регионов РФ, выявления препятствий и условий для его активного внедрения в хозяйствах. Основными направлениями, способствующими развитию цифровизации АПК региона выделены: подготовка и переподготовка кадрового состава агросферы региона среднего и высшего звена, развитие широкополосного интернета и сотовой связи в сельской местности, доступное финансовое обеспечение инновационных проектов в АПК, налоговые и кредитные льготы для предприятий внедряющих новые технологии.

Digital development of the agro-industrial complex of the region is possible on the basis of studying foreign experience and the experience of advanced regions of the Russian Federation, identifying obstacles and conditions for its active implementation in farms. The main directions contributing to the development of digitalization of the agro-industrial complex of the region are: training and retraining of the personnel of the agro-sphere of the region of middle and senior management, the development of broadband Internet and cellular communications in rural areas, affordable financial support for innovative projects in the agro-industrial complex, tax and credit benefits for enterprises implementing new technologies. Agro-industrial complex, digital development of the region, North Caucasus Federal District.
The system-forming role of the Arctic cluster in the developmentof the economy of the North of Russia(on the example of the Murmansk region)
Authors: Лычкина Л.С. , Хаценко Е.С.
Published: March 2022

Представленная статья посвящена оценке состояния и перспективам развития кластерных инициатив, как основе пространственного развития Арктической зоны Российской Федерации; сделан анализ стратегического развития и направлений кластерной политики циркумополярных регионов и произведена оценка кластерного потенциала перспективных отраслей Арктической зоны РФ.

The presented article is devoted to the theoretical and legal aspects of the formation of the economic policy of the Russian Arctic, the creation and regulation of the Arctic economic cluster.
Mechanical activation of zirconium with a degradable polymer in various atmospheres
Authors: Титова В.А. , Рева В.П.
Published: March 2022

В статье рассмотрены механохимические процессы, реализуемые в результате механоактивации циркония совместно с деструктируемым полимером при использовании различных рабочих атмосфер. Рассмотрен фазовый состав порошковых материалов.

The article discusses the mechanochemical processes realized as a result of mechanical activation of zirconium with a degradable polymer using different working atmospheres. The phase composition of powder materials is considered.
Deadbeat two-vector model predictive current control for open-winding primary permanent-magnet linear motor
Authors: Tang Hongyu , Sha Ou , Yang Zhenli , Xu Dezhi
Published: March 2022

The structure of open-winding motor fed by the dual-inverter can increase the winding terminal voltage of the primary permanent-magnet linear motor (PPMLM). So, it is an effective method to improve the thrust performance of the PPMLM. Based on the detailed derivation of the mathematical model of the open-winding PPMLM and the in-depth analysis of the space voltage vector distribution characteristics of the dual-inverter, a deadbeat two-vector model predictive current control (MPCC) model is proposed in this paper. First, the optimal vector of the inverter 1 is determined by judging the position of the large sector. Second, two optimal vectors of the inverter 2 is determined by judging the position of the small sector. Finally, the duty cycle of the two optimal vectors of the inverter 2 is calculated to realize the proposed deadbeat two-vector MPCC algorithm. Compared with the traditional model predictive torque control (MPTC) and MPCC strategies, the proposed algorithm has the advantages of lower current harmonics (lower 34 % and 44 % under rated conditions, respectively) and better thrust performance (higher 77 % and 61 % under rated conditions, respectively) as well as lower computational complexity. Simulation and experimental results show that the proposed two-vector MPCC has good steady-state and dynamic performances, which can reduce the current harmonics and thrust ripple, and thus improve the motor drive performance compared with the traditional method.
Evaluation of four bias correction methods and random forest model for climate change projection in the Mara River Basin, East Africa
Authors: das Priyanko , Zhang Zhenke , Ren Hang
Published: March 2022

This study evaluates the performance of four bias correction methods based on CORDEX (coordinated regional climate downscaling experiment) domain six regional climate models (RCMs) at the Mara River Basin. A suitable bias correction method was considered to develop the future climate scenario. The performance of bias correction methods was evaluated by various statistical metrics based on the historical period and revealed that the distribution mapping (DM) techniques have strong performance under the different climatic conditions. The effectiveness of the DM method is found to be better at capturing the coefficient of variation and standard deviation of observed rainfall and temperature. Therefore, this study considers the future climate (2026–2095) from bias-corrected RCMs output using DM techniques. The results from bias-adjusted RCMs show an increase of rainfall (+118.3%) and temperature (+2.91) in the future climate under Representative Concentration Pathways (RCPs) 2.6, 4.5 and 8.5. In addition, this study tested the random forest (RF) method to determine the capacity of each bias-corrected RCMs for reproducing the future rainfall and temperature under the RCP 4.5 and RCP 8.5 scenario. The results demonstrate that the RF can reproduce the climate variable with its average correlation (R2) of 0.93 for rainfall and 0.95 for temperature.
Measurements of boron concentration from rivers in northern Basrah Governorate using SSNTDs
Authors: Algrifi Mostafa A. , Salman Thaer M.
Published: March 2022

Consumption of boron-contaminated food and drinking water poses several health risks to consumers. As a result, the boron content in food particles must be measured. Drinking water samples were obtained from several locations in northern Basrah, Iraq, for this investigation. The Solid State Nuclear Track Detector (SSNTDs) technique was used to examine the obtained water samples to identify boron levels. Boron levels were found to range from 0.28 ppm in Al Alwa (Al Qurnah) (tap water) to 1.85 ppm in Oil Street. This study's findings were compared to international standard values and previously published research. These findings may be utilized by the Iraqi government to develop guidelines to decrease radioactive contamination of drinking water in Basrah. The 41 surface water samples tested in this study had boron levels that were lower than the international standard limits. As a result, the boron level in Basrah's drinking water is normal. However, there is a chance that boron contamination will become a serious concern shortly. As a result, additional research is required in the future.
MPTP as a Molecular Paradigm for Neurodegeneration. A Review of its Connections with Relevant Molecules
Authors: Vidaluc Jean-Louis
Published: March 2022

The parkinsonian neurotoxin MPTP was reviewed with special interest in its structural features including close analogs and its biological connections with relevant molecules able to reverse or protect against its neurotoxic effects. Thus, some fifty efficient molecules displaying structural diversities and affinities towards a number of receptors with variable known implications in neurodegenerative diseases or in the neurotoxicity of MPTP, were highlighted.
The Epidermal Growth Factor Receptor Family of Tyrosine Kinases and Cancer: Can An Atypical Exemplar Be A Sound Therapeutic Target?
Authors: Bridges A. J.
Published: March 2022

Epidermal Growth Factor (EGF) receptor was the first peptide growth hormone receptor found to contain an intracellular tyrosine kinase. It is frequently used to exemplify the properties of the whole family of receptor
tyrosine kinases. Much work has been done on EGFr to elucidate the mechanisms of activation
of RTKs, and their coupling to downstream signaling processes. The type I RTKs consist of four closely related RTKs, and a bewildering number of ligands. The number of ligands is not typical for RTKs, but the discovery that this family can form signaling-competent heterodimers as well as homodimers may explain this abundance. The type I RTKs are almost ubiquitous in solid neoplasias, as 90% of clinical samples express at least one family member, and at least 60% of tumours overexpress at least one of the receptors or cognate growth factors. Overexpression correlates with poor prognosis and shorter survival times. The high prevalence suggests that type I RTKs may activate more transforming signaling pathways that most other RTKs. Both the high prevalence, and the importance of the EGFr family to the transformed phenotype, suggest that inhibition of their signaling will have therapeutic utility. This has been investigated by finding blocking antibodies for the ligand binding domains of the receptors, enzyme inhibitors for the tyrosine kinases of the family and inhibitors of downstream signaling. The enzyme inhibitor approach has led to small molecule enzyme inhibitors of great potency and selectivity for the EGFr tyrosine kinase.
Myocardial Protection with the ATP-Sensitive Potassium Channel Openers
Authors: Atwal Karnail S.
Published: March 2022

The ATP-sensitive potassium channel (KArP) openers (e.g., Cromakalim) were originally developed for the treatment of hypertension, primarily due to their potent peripheral vasodilating properties. However, the clinical studies have failed to demonstrate any advantage of these compounds over the more established antihypertensive agents. Experimen­ tal studies have shown that the KArP openers may be effective for the treat­
ment of a variety of diseases (asthma, urinary incontinence, ischemia etc.) besides
hypertension. However, their clinical utility is limited due to lack of tissue selectivity. We have shown that KArP openers have direct cardioprotective properties which do ,!lOt require contribution from vasodilation. However, the first generation agents offer a narrow window of safety for the treatment of myocardial ischemia due to their potent peripheral vasodilating properties which can compromise the tissue already at risk. Our efforts to find cardioprotective KArP openers with a lower degree of vasorelaxant potency relative to the first generation agents have resulted in the identification of a new class of agents (5). Their structure-activity relationships for antiischemic activity and efficacy in vivo are summarized in this review. The structure-activity studies show that an electron withdrawing group at C6 of the benzopyran ring, a gem-dimethyl at C2, a trans-hydroxyl at C3, an sp3 carbon at C3/C4 and an aryl ring attached to the nitrogen of the cyanoguanidine moiety are required for antiischemic activity. The mechanism of action of these compounds appear to involve opening of the KArP as structurally distinct KATP blockers abolish the cardioprotective effects of these compounds. Unlike the first generation compounds (e.g., cromakalim), the more selective KATP openers can be administered iv to observe antiischemic efficacy. The mechanism of antiischemic activity of KArP openers does not appear to involve the sarcolemmal KArP as their antiischemic activity is independent of action potential shortening. Progress at understanding the molecular mechanism of action of KArP openers and opportunities for future research are also discussed in this article.
Phytocompounds from the Medicinal and Dietary Plants: Multi-target Agents for Cervical Cancer Prevention and Therapy
Authors: Shoaib Shoaib , Islam Najmul , Yusuf Nabiha
Published: March 2022

Cervical cancer is the fourth leading cause of cancer death among women worldwide. Due to cervical cancer's high incidence and mortality, there is an unmet demand for effective diagnostic, therapeutic, and preventive agents. At present, the preferred treatment strategies for advanced metastatic cervical cancer include surgery, radiotherapy, and chemotherapy. However, cervical cancer is gradually developing resistance to chemotherapy, thereby reducing its efficacy. Over the last several decades, phytochemicals, a general term for compounds produced from plants, have gained attention for their role in preventing cervical cancer. This role in cervical cancer prevention has garnered attention on the medicinal properties of fruits and vegetables. Phytochemicals are currently being evaluated for their ability to block proteins involved in carcinogenesis and chemoresistance against cervical cancer. Chemoresistance to cancer drugs like cisplatin, doxorubicin, and 5-fluorouracil has become a significant limitation of drug-based chemotherapy. However, the combination of cisplatin with other phytochemicals has been identified as a promising alternative to subjugate cisplatin resistance. Phytochemicals are promising chemo-preventive and chemotherapeutic agents as they possess antioxidant, anti-inflammatory, and anti-proliferative potential against many cancers, including cervical cancer. Furthermore, the ability of the phytochemicals to modulate cellular signaling pathways through up and down regulation of various proteins has been claimed for their therapeutic potential. Phytochemicals also display a wide range of biological functions, including cell cycle arrest, apoptosis induction, inhibition of invasion, and migration in cervical cancer cells. Numerous studies have revealed the critical role of different signaling proteins and their signaling pathways in the pathogenesis of cervical cancer. Here, we review the ability of several dietary phytochemicals to alter carcinogenesis by modulating various molecular targets.
Antiviral Compounds Based on Natural Astragalus polysaccharides (APS): Research and Foresight in the Strategies for Combating SARS-CoV-2 (COVID-19)
Authors: Rafieian-Kopaei Mahmoud , Aleebrahim-Dehkordi Elahe , Heidari-Soureshjani Ehsan , Aryan Alisam , Ganjirad Zahra , Soveyzi Faezeh , Hoseinsalari Afsaneh , Derisi Mohamad Mehdi
Published: March 2022

Today, finding natural polymers with desirable properties for use in various industries is one of the critical axes of research in the world. Polysaccharides are a group of natural polymers that have various applications in the pharmaceutical industry. The attachment of monosaccharides forms polysaccharides through glycosidic bonds that are widely found in various sources, including plants. Genus Astragalus belongs to the Fabaceae family. Plants belonging to this genus have different polysaccharides. Astragalus polysaccharides (APS) have attracted a great deal of attention among natural polymers because they are non-toxic, biodegradable, and biocompatible. Currently, APS have great drug potential for curing or treating various diseases. Due to the different biological activities of polysaccharides, including Astragalus, this study has investigated the chemical structure of APS, reporting on the antiviral and anti-inflammatory activities as well as stimulation of cytokine secretion by these polysaccharides. Also, in this study, the pharmaceutical approaches of APS compounds, as a natural, new and inexpensive source, have been discussed as suitable candidates for use in pharmaceutical formulations and preparation of new drugs to control COVID-19 infection
Synthesis and Anticancer Activities of Novel Bis-chalcones Incorporating
the 1,3-diphenyl-1H-pyrazole Moiety: In Silico and In Vitro Studies
Authors: Mohamed Magda F. , Sroor Farid M. , Elsayed Shahinda E. , Mahrous Karima F. , Mageed Lamiaa , Hanafy Mahmoud Khaled , Ibrahim Sherif A. , Elwahy Ahmed H. M. , Abdelhamid Ismail A.
Published: March 2022

A new series of bis-chalcones 5-10 has been prepared by the condensation reaction of one
equivalent of bis(acetophenones) 3a-f with two equivalents of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde
4. The newly prepared compounds 5-10 have been fully characterized and evaluated as in vitro anticancer
agents against a panel of human cancer cell lines A431, A549, PC3, and a normal human skin
fibroblast BJ1.

Aims:

The current work is designed to explore the anti-cancer activity of novel bis-chalcones incorporating
a 1,3-diphenyl-1H-pyrazole moiety.

Background:

Chalcones represent one of the most important organic compounds that have been attracting
the interest of many researchers in drug discovery.

Objective:

The present study was carried out to explore anti-cancer activity of novel bis-chalcones incorporating
a 1,3-diphenyl-1H-pyrazole moiety as in vitro and in silico studies.

Materials and Methods:

We used the condensation reaction to prepare bis-chalcones incorporating 1,3-
diphenyl-1H-pyrazole moiety. The MTT Assay, Anti-cancer activity, Gene expression, DNA Fragmentation,
DNA Damage, and Molecular docking were investigated.

Results:

Compounds 5 and 9 were found to be the most promising compounds in the prepared series with
IC50 (50.3 and 50.1 μg/ml, respectively) against epidermoid cancer cell line A431 compared to doxorubicin
as a reference drug.

Conclusion:

All of these results showed that chalcones 5 and 9 have promising anti-cancer properties
without cytotoxic effect, which could make them a promising active component for further studies.
Novel S-Mercaptotriazolebenzothiazole-Based Derivatives as Antimicrobial
Agents: Design, Synthesis, and In Vitro Evaluation
Authors: Alqahtani Alaa M. , El-Din Asmaa G. Safi , Abdou Randa , Amin Ali H. , Arab Hany H. , Abdelazeem Ahmed H.
Published: March 2022

Background:

The search for novel antimicrobial agents effective against the emerging resistant
pathogenic microorganisms to the currently used drugs is a substantial need. Herein, a novel series of
compounds bearing a benzothiazolotriazole scaffold was synthesized and evaluated as potential antimicrobial
agents against a panel of gram +ve, gram -ve bacteria, and fungi species.

Methods:

The new compounds were synthesized via hybridization between the benzothiazolotriazole
scaffold and thiadiazole ring or various substituted aromatic moieties using the tethering technique in
drug discovery.

Results:

The in vitro results revealed that these compounds have significant antifungal activity rather than
antibacterial potential due to their high similarity with tricyclazole. Compound 7b bearing bromo-phenyl
moiety was the most potent derivative with an MIC value of 8 μg/mL against Candida albicans and Penicillium
chrysogenum.

Conclusion:

Collectively, benzothiazolotriazole-based derivatives are good antifungal leads and should
be further actively pursued to expand treatment options for systemic and topical fungal infections.