bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge Graph Decision Transformer:Conditional sequence decision-making model for Offline RL integrated with knowledge graph
Authors: He Shan , Lu Zhaoyang
Published: June 2024

Decision Transformer is one of the representative algorithms in the field of offline reinforcement learning for conditional sequence modeling. It can learn from past decisions and predict future action strategies, performing well in most tasks. However, recent research indicates its limitations in concatenating different trajectory segments, meaning it struggles to utilize suboptimal trajectories effectively. This paper combines Decision Transformer with knowledge graph link prediction, leveraging the strengths of both methods to enhance decision-making in complex environments. While Decision Transformer provides a robust framework for handling sequential data, knowledge graph link prediction offers structured representations of entity relationships and predicts potential links between entities, allowing the model to infer unobserved state transitions. By integrating knowledge graph predictions into the Decision Transformer model, we can enhance decision accuracy by leveraging additional contextual and relational information. This synergy enables more effective utilization of available data and better adaptation to diverse scenarios. Through experiments and evaluations, we have demonstrated the effectiveness of this integration approach in improving the performance of offline reinforcement learning models across various tasks and domains.
Mechanism of Rhubarb and Agastache rugosa in the treatment of renal cell carcinoma based on network pharmacology and experimental validation
Authors: Li Jiaqing , Yuan Ling , Zhang Lei , Jiang Wenjie , Jiao Taiqiang , Yang Niu , Dou Hongli , Nan Yi
Published: June 2024

Purpose Network pharmacology and molecular docking were uesd to forecast the related effect targets and potential signal pathways of Rhubarb and Agastache rugosa in curing renal cancer. Methods Searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) to screen the effective ingredients and targets of Rhubarb and Agastache rugosa, the differential genes related to renal cancer were obtained by searching GEO database. Construct the regulatory networks and protein-protein interaction(PPI) networks using Cytoscape 3.9.1 software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were analyzed based on Metascape database, the gene set was analyzed by GSEA. The active components and core genes were molecular docked, and the core genes were analyzed for clinical correlation and immune infiltration. Finally, in order to verify the results of network pharmacological analysis, we performed cell experiments with 786-O cells and ACHN cells in vitro. Results The top six core genes, EGFR, HSP90AA1, MMP9, KDR, CA9, and LDHA, were identified by network pharmacological analysis; and Rhubarb and Agastache rugosa was predicted to play a role in the PI3K/Akt/mTOR pathway through central carbon metabolism in cancer. Cellular experiments showed that Rhubarb and Agastache rugosa restrained the proliferation of 786-O and ACHN cells, induced apoptosis, arrested the cell cycle, and reduced the colony forming ability of cells. qRT-PCR results showed that the expression of core targets of EGFR, HSP90AA1, MMP9, KDR, CA9, and LDHA were significantly down-regulated. Western blot results showed that the protein expression levels of EGFR, p-PI3K, PI3K, p-Akt/Akt, and p-mTOR/mTOR were significantly down-regulated. Discuss The core targets in the effective components of Rhubarb and Agastache rugosa may be to inhibit the development and proliferation of renal carcinoma cells through the PI3K/Akt/mTOR pathways.
Low temperature exposure decreases Cry1Ac insecticidal endotoxin content in cotton seeds
Authors: Chen Yuan , Dong Shu , Dai Yuyang , Zhang Xiang , Chen Dehua , Chen Yinglong , Liu Zhenyu
Published: June 2024

Background
Sudden temperature drops, resulting from extreme weather events, often occur during the boll-setting period of cotton in Xinjiang, China, causing decreased expression of Bacillus thuringiensis (Bt) insecticidal proteins in cotton bolls. The precise threshold temperatures and durations that lead to significant changes in Cry1Ac endotoxin levels under low temperatures remain unclear. To address this, we investigated the effects of different temperatures and stress durations on Cry1Ac endotoxin levels in cotton bolls. In 2020–2021, two Bt transgenic cotton cultivars, conventional Sikang1 and hybrid Sikang3, were selected as experimental materials. Various low temperatures (ranging from 16 to 20°C) with different durations (12h, 24h and 48h) were applied during the peak boll-setting period.
Results
As the temperature decreased, the Cry1Ac endotoxin content in the boll shell, fiber, and seed exhibited a declining trend. Moreover, the temperature causing a significant change in Cry1Ac endotoxin content increased with the prolonged duration of low-temperature stress. Among the components of cotton bolls, seeds were most affected by low-temperature stress, with the threshold temperature for a significant reduction in Cry1Ac endotoxin content ranging from 17°C to 19°C. Correlation analysis indicated that low temperatures led to a decrease in protein synthesis capacity and an increase in degradation ability, resulting in reduced Cry1Ac endotoxin content. Pathway analysis revealed that both amino acid and peptidase had significant negative effects on Cry1Ac endotoxin content.
Conclusion
In summary, when the daily average temperature was ≤ 19°C, implementing cultural practices to reduce free amino acid content and peptidase activity could serve as effective cold defense strategies for Bt cotton production.
Balanced Iterative Reduction and Clustering Using Hierarchies (BIRCH) methods to Prioritize and reduce Test Suites
Authors: Prabhakar Prajith , Venkatesh Yokesh , Prasanth A , Sathish N
Published: June 2024

Throughout testing, there is an abundance of duplicate test cases to ensure that the new code will not impact the program that has previously been tested with every possible combination. Essential as it may be, software testing may be expensive, especially when test cases are not based on real-world events. By combining state-of-the-art Balanced Iterative Reducing and Clustering Using Hierarchies (BIRCH) techniques with the Fruit Fly optimization (FFO) methodology, we can use fewer test cases to reduce challenging time while still providing accurate results and making effective use of resources. BIRCH does away with the original data points and instead creates clustered summaries from them. The BIRCH-FFO clustering method produced a full test suite with full path coverage while significantly reducing the number of experimental cases.
Energy efficient clustering routing algorithm based on improved FCM
Authors: Sun Qian , Meng Xiangyue , Zhao Zhiyao , Xu Jiping , Zhang Huiyan , Wang Li , Yu Jiabin , Liu Guoxin
Published: June 2024

Wireless sensor networks (WSNs) play a crucial role in the Internet of Things (IoT). The sensor nodes(SNs) in WSNs are powered by batteries, making energy efficiency and network lifetime key issues in WSNs research. Cluster-routing algorithms are a focal point for addressing energy efficiency challenges. Selecting cluster heads (CHs) based on clustering algorithms can reduce the energy consumption of SNs and enhance overall network stability and sustainability. This paper introduces a method for selecting the number of clusters (\({N_C}\)) and CHs based on fuzzy clustering. The fuzzy C-means (FCM) clustering algorithm requires pre-setting the number of clusters, with no inclusion of CHs information in the output after running the algorithm. The number of clusters and selection of CHs were determined using the elbow rule and scoring criteria for CHs selection. The performance of the network under different monitoring areas is simulated and analyzed in this paper. Experiments demonstrate that the proposed algorithm outperforms existing algorithms in terms of network energy consumption and lifetime.
Knockdown of lncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration
Authors: Hu Xiuwen , Zeng Fanfei , Chen Ziyu , Hu Kuan , Chen Qingsong , Xia Yun , Yang Hongyu
Published: June 2024

Hand–arm vibration syndrome (HAVS) is caused by long-term exposure to hand-transmitted vibration (HTV), and its pathogenesis has not been elucidated fully. We explored the molecular mechanism of HAVS and provided clues and a theoretical basis for the early prevention and treatment of HAVS. After vibration, samples were collected from the plasma of human workers, plasma of rat tails, and human umbilical vein endothelial cells (HUVECs). ELISAs were used to measure the expression of vasoactive factors. Cell Counting Kit-8 and electron microscopy were used to detect cell damage. Flow cytometry was employed to detect apoptosis. Real-time reverse transcription-polymerase chain reaction was used to measure the expression of long non-coding RNAs (lncRNAs). Western blotting was used to measure the expression of apoptosis-related proteins. Vibration could cause cell damage, apoptosis, and changes in the expression vasoactive factors and lncRNAs. The lncRNA maternally expressed gene 3 (MEG3) had a significant regulatory effect on cell damage, apoptotic proteins, and vascular regulatory factors in the HUVEC damage induced by vibration, as shown by the further decrease in viability and aggravation of injury after knockdown of MEG3 expression in HUVECs treated with vibration. Expression of vasoactive factors and apoptosis-related proteins was changed after interfering with MEG3 expression. In conclusion, vibration can affect the expression of vasoactive factors and lncRNA, and cause damage to vascular endothelial cells. MEG3 may be involved in the inflammatory damage to vascular endothelial cells induced by vibration.
Usangu rainfall variability analysis: Unveiling spatio-temporal trend, distribution and concentration of rainfall in a semi-arid region
Authors: Kavishe Rosemary , Mulungu Deogratias , Alexander Augustina
Published: June 2024

Rainfall unpredictability in semi-arid climates affects the quality and quantity of water available for socioeconomic activities, ecological maintenance and developmental projects. Understanding rainfall characteristics such as trend, distribution, and concentration is important for managing water resources and planning to mitigate impacts from rainfall uncertainty. This study was conducted in the Usangu catchment located in a semi-arid environment with three competing users agricultural land upstream, and the National Park and hydropower plant. A multidisciplinary approach that integrated statistical methods, hydrological analysis and geographic information system (GIS) tools was used to unveil a spatio-temporal trend and variability of annual rainfall in Usangu. The results indicated a significant trend for all stations except Mafinga station. The highest decrease was at Kimani (S=-6.13) and the highest increase at Matamba (S = 2.93). There is a distinct distribution of rainfall between the highlands (800-1,200 mm/year) and lowlands (500–800 mm/year). Rainfall is concentrated in short periods indicated by higher precipitation concentration index (PCI) values ranging from (18.8 to 23.6). There is less dispersion of rainfall at station N based on the coefficient of variation (CV = 17.1%) and high dispersion at Kimani (CV = 33.6%) but the majority of the catchment experienced consistent rainfall patterns. According to the standardised anomaly index (SAI), oftentimes the catchment experienced normal conditions (32 years out of 42 years) which accounts for 77%. Also, extreme drought conditions are more dominant in the lowlands than in the highlands. The results of this study are useful for long-term planning of water resources utilization in Usangu.
Nitrophenyl-Group-Containing Heterocycles. 2. Synthesis, Characterization, Anticancer Activity, Apoptotic Induction and Cell Cycle Arrest of Some New 5,6,7,8-Tetrahydro-isoquinolines Bearing 2-Nitrophenyl Group
Authors: Saddik Abdelreheem A. , Bakhite Etify A. , Hassanien Reda , Farhan Nasser , Sayed Eman M. , Sharaky Marwa
Published: June 2024

In this work 7-Acetyl-4-cyano-1, 6-dimethyl-6-hydroxy-8-(2-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2H)-thione compound 2 was synthesized and used as starting materials. Subsequently, Compounds 3–7 were produced through its reaction with ethyl iodide, ethyl chloroacetate, chloroacetonitrile, and chloroacetaldehyde. Additionally, compound 2 and 2-chloroacetamide were heated in ethanol with sodium acetate trihydrate present, resulting in the formation of 3-Substituted methylthio-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles 9a–d, respectively. Similarly, compounds 2 and N-(1-naphthyl)-2-chloroacetamide reacted to produce high yields of the equivalent N-(1-naphthyl)-(5,6,7,8-tetrahydroiso-quinolin-3-ylthio)acetamides 9e. Compounds 9a–e were cyclized into their 10a and d. Using elemental analysis and spectral data (FT-IR, 1H NMR, and 13C NMR). All newly synthesized compounds were described. The anticancer activity of the produced compounds was also assessed against eight cell lines at one spot concentration and one normal human skin fibroblast cell line HSF. Then determine the IC50 of our drugs against two specific cell lines using various doses. Compound 3 is the most effective chemical against HEGP2, according to our research. Compound 9c was also the most effective compound against HCT116. For generally, the tested substances showed moderate anticancer activity, according to the data. The effects of compound 3 on the proliferation of HEGP2 cell lines were then investigated using an apoptotic Annexin V-FITC assay and flow cytometry. Compound 3 increased the HEGP2 cell line's apoptosis by 50 times and caused cell cycle arrest at the G2/M phase.
Usefulness of accounting information systems for small business profitability in South Africa: A systematic literature review
Authors: Freddy Aliamutu Kansilembo , Vitalis Mkhize Msizi
Published: June 2024

Accounting information systems are an important instrument in the hands of administrators seeking to maintain a competitive edge in the face of fast technological innovation, having the knowledge, and demanding expectations from customers and business owners. The objective of the study is to investigate the empirical literature pertaining to accounting information systems and companies. This study uses a systematic literature review method to provide responses to the research issue, and the bulk of the research was conducted in industrialized economies where computerized accounting system approaches were widely adopted. The selected method of inquiry consists of the following phases: study choice, development of both inclusion and exclusion guidelines, research designation, quality of research assessment, data collection, and data compilation. Based on the paper’s findings, most small businesses fail to implement accounting information systems in their operations, resulting in low-efficiency levels because of the difficulty of preserving company information records. Furthermore, this systematic literature review adds to the prior literature in three ways: (1) it indicates the usefulness of accounting information systems; (2) it expresses the suggestions that might be implemented to boost the accounting information system; and (3) it describes the research gaps that require to be filled to encourage an improved adoption of accounting information systems for small business profitability.
Implementing Character Education Based on Local Wisdom in a Public Islamic Elementary School
Authors: Mansur Mansur , Sholeh Makherus
Published: June 2024

This study centers on implementing Character Education based on Local Wisdom at Public Islamic Elementary School 4 Banjar. It highlights the indispensable role of educators in imparting character values to students through local culture and wisdom. The research aims to grasp how Character Education based on local wisdom is practiced at Public Islamic Elementary School 4 Banjar Sungai Lulut and the factors that either facilitate or hinder its implementation. Employing a qualitative approach with a descriptive method, the study examines the activities and execution of Character Education based on local wisdom, involving teachers and students as research subjects. Data collection techniques encompass observation, interviews, and documentation, while data analysis involves data reduction, presentation, and conclusion. The findings demonstrate that the school effectively integrates local wisdom into Character Education through activities such as adopting the 5S culture (smile, greeting, greeting, politeness, and politeness), religious practices, sports, and scouting, all contributing to student character development. Supportive factors such as adequate facilities, the active role of teachers, parental involvement, and the inclusion of character education in the school curriculum further enhance the implementation. Conversely, inhibiting factors such as students' lack of awareness and insufficient facilities and infrastructure present challenges to the process. These findings hold practical implications for educators, researchers, and policymakers interested in character education and implementing local wisdom in elementary schools.
Classification of Clove Leaf Blister Blight Disease Severity Using Pre-trained Model VGG16, InceptionV3, and ResNet
Authors: Pramesti Putri Ayu , Supriyadi Muhamad Rodhi , Alfin Muhammad Reza , Noveriza Rita , Wahyuno Dono , Manohara Dyah , Melati  , Miftakhurohmah  , Warman Riki , Hardiyanti Siti , Asnawi
Published: June 2024

Clove is one of the precious plants produced in Indonesia. Clove has many benefits for humans, but clove cultivation often experiences problems due to disease attacks, including Leaf Blister Blight Disease(CDC). The handling of CDC disease is carried out based on the severity of the symptoms that can be seen on the affected leaves. This research was conducted to obtain a CDC disease classification model, so appropriate treatment can be carried out. This study used the pre-trained VGG16, InceptionV3, and ResNet models for classification. VGG16 got the highest average accuracy of 96.7%. Aside from that, k-fold cross validation improved the model's accuracy.
Promising approaches to noninvasive diagnosis of subclinical cardiovascular toxicity of chemotherapy
Authors: Khardikova Elena M. , Meshcherina Natalia S. , Mikhailenko Tatiana S. , Leontieva Tatiana S.
Published: June 2024

Objective: to present data on available modern methods of diagnosis of subclinical cardiovascular toxicity of chemotherapy. Modern strategies of treatment of cancer allow to stable remission and increase life expectancy of patients, the success of which is balanced by increased mortality of cancer patients due to the development of side effects of chemotherapy, the most prognostically significant of which are cardiovascular complications. Early diagnosis of cardiovascular toxicity in cancer patients is a “new” priority for collaboration of oncologists and cardiologists, as the development or progression of an already existing heart disease has a significant impact on the duration and quality of life of cancer patients. This review, at the current level of development of medical science, presents methods of diagnosis and monitoring of subclinical cardiovascular toxicity against the background of chemotherapy. Use for the diagnosis of subclinical cardiotoxicity such modern methods of visualization as two- and three-dimensional echocardiography, echocardiography with the definition of global longitudinal deformation of the myocardium - spectrum-tracking echocardiography, myocardial work, magnetic resonance tomography, definition of diastolic dysfunction allows to identify manifestations of cardiovascular toxicity in earlier terms, thereby affecting the prognosis and quality of life in cancer patients receiving chemotherapy treatment.
Transassassinatos, vidas precárias e necropolítica
Authors: Amarante Nascimento Vinícius
Published: June 2024

Esta pesquisa procurou analisar, a partir de dados fornecidos pela Associação Nacional de Travestis e Transexuais (ANTRA), os homicídios cometidos contra mulheres transexuais e travestis no Brasil no ano de 2022. Destaca-se que mulheres transexuais e travestis possuem uma identidade de gênero feminina que se difere daquela que lhes foi atribuída no registro civil como masculina. Por buscarem viver na sociedade  com sua identidade autopercebida, acabam sofrendo com inúmeras formas de preconceito e discriminação na instância familiar, escolar, laboral, para ter acesso a saúde e a direitos básicos, ficando passíveis da violência transfóbica, já que, só no ano de 2022 foi contabilizado pela ANTRA, especificamente, o número de 130 assassinatos de mulheres transexuais e travestis no Brasil. Esta pesquisa teve como método procedimental, o bibliográfico e documental e como objetivo principal analisar os mecanismos necropolíticos na sociedade que operam a morte física e simbólica de mulheres transexuais e travestis.
OS IMPACTOS NAS ATIVIDADES DE GERAÇÃO DE RENDA EM HABITAÇÃO SOCIAL
Authors: Martins Bruna Cristina , Barbosa Villa Simone
Published: June 2024

Os projetos de Habitação Social (HS) apresentam tipologias padronizadas em todo o Brasil, oferecendo moradias pouco resilientes aos impactos frequentemente percebidos. A moradia social é ofertada de forma precária, pouco compatível com as demandas da vida cotidiana e moderna de seus moradores, não prevendo principalmente reformas e, tampouco, espaço para atividades de renda. Sendo assim, verifica-se nesses espaços domésticos a frequente sobreposição de atividades do cotidiano e de geração renda de seus moradores. No Brasil, é muito comum em bairros populares encontrar HS com modificações e adaptações realizadas pelos próprios moradores para abrigar atividades de serviço e/ou comércio nas casas. Nesse sentido, constata-se uma lacuna de pesquisas relacionadas às atividades de geração de renda em HS. Este artigo tem como objetivo principal apresentar parte dos resultados obtidos na pesquisa de mestrado ‘Adaptação e reforma da habitação  social para renda: Análises para intervenções mais resilientes’ do Programa de Pós-Graduação em Arquitetura e Urbanismo e Design da Universidade Federal de Uberlândia-MG1. A pesquisa foi baseada no Design Science Research (DSR) e utilizou-se como Estudo de Caso dois conjuntos populares enquadrados na Faixa 1 do Programa Minha Casa Minha Vida (PMCMV) na cidade de Uberlândia-MG. Foram realizadas Pesquisa de Campo a partir dos estudos de observação, aplicação de Avaliação Pós-Ocupação (APO) e análise comparativa. Os estudos objetivaram levantamento e análise da ocorrência da geração de renda nas HS estudadas e puderam verificar os impactos sofridos, evidenciando a baixa resiliência no ambiente construído.
Focus
Authors: Van Vlastuin W.
Published: June 2024

N.a.v.:
Michael Allen (red.), The New Cambridge Companion to Christian Doctrine (Cambridge: Cambridge University Press, 2023) $ 26.21 (ISBN9781108840446).
Antibacterial Activity of Green Meniran Extract (Phyllanthus niruri Linn) on The Growth of Salmonella typhimurium
Authors: Nafisah Aulia Erta , Octavia Bernadetta , Lestari Endang Gati
Published: June 2024

Salmonella typhimuriumis a bacterium that causes digestive infections, gastroenteritis, and food poisoning, psickcaused byBacterial infection is a health problem in developing countries, including Indonesia. Green meniran (Phyllanthus niruri L.), is a herbaceous plant containing flavonoids, alkaloids, saponins, and tannins which have antibacterial activity which is expected to suppress the development of Salmonella sp. The aim of the study was to determine the ability of green meniran extract as an antibacterial to inhibit the growth of Salmonella typhimurium bacteria. The study used a completely randomized factorial design consisting of two factors, namely extract concentrations of 5%, 10%, 20%, 40%, 80%, equipped with a positive control (chloramphenicol) and negative control (aquades), as well as the age of the inoculum of the bacterial growth phase. Testing the antibacterial activity using the Kirby-Bauer disc diffusion method. The results showed that green meniran extract had antibacterial activity against the growth of Salmonella typhimurium bacteria. Concentrations of 5%, 10%, 20%, 40%, and 80% produced inhibition zone diameters of 6.7 mm, 8.5 mm, 9.9 mm, 12 mm, and 14.6 mm, respectively. The concentration of 80% green meniran extract is effective in inhibiting the growth of Salmonella typhimurium bacteria with an antibacterial effectiveness value of 58.95%.
Investment Feasibility and Strategic Development Scenarios of Yogyakarta-Bawen Toll Road
Authors: Danubroto Radyo Wijoyo , Malkhamah Siti , Amrozi Muhammad Rizka Fahmi
Published: June 2024

This study examines the feasibility of the investment in the Yogyakarta-Bawen toll road project by analyzing traffic conditions, expenditure costs, toll revenues, and investment value. Simulation using PTV Visum shows a significant increase in the volume-to-capacity ratio (VCR) on the national road sections around the toll road until 2061. The modeling result also indicates that the operation of the toll road reduces traffic loads on several surrounding national road sections with a decrease in VCR. The analysis results reveal a negative net present value (NPV) amounting to -Rp.506,560,648,100, and an internal rate of return (IRR) of 11.49% is under the discount rate (12.03%). In the tariff adjustment scenario, the project shows an IRR of 12.48% with an NPV of Rp 575,501 million, and the payback period (PBP) is achieved after 16 years. In the concession adjustment scenario, the IRR is 12.12% with an NPV of Rp 123,461 million, and the PBP is achieved after 17 years. Meanwhile, the tariff and concession adjustment scenario show an IRR of 12.48% with an NPV of Rp 652,033 million, and the PBP is achieved after 16 years. Based on the investment feasibility evaluation, the recommended best strategy is tariff adjustment. This strategy allows for an optimal increase in toll revenue and investment returns. It is expected that the Yogyakarta-Bawen toll road project can achieve better investment feasibility and provide long-term benefits to investors, road users, and the overall community.
Landslide Mitigation at The Bagong Dam Abutment, Trenggalek District
Authors: Hilmawan Gilang Bobby , Sriyana Ignatius
Published: June 2024

Landslides occurred continuously from July 2022 until July 2023, disrupting the construction of the Bagong Dam abutment. Geologically, the foundation of the Bagong Dam consists of a fairly thick colluvial layer, which is prone to landslides. So, the analysis of landslide mitigation at the Bagong Dam abutment is needed. The slope stability analysis carried out by Fellenius and Bishop method, then the slope modeling was carried out using Geostudio software. The analysis results on the existing slopes produced a safety factor of 0.987 (1.07) for the Fellenius method and 1.042 (1.07) for the Bishop method. These safety factors indicate that the existing slope is unstable and slope failure is likely to occur. In the first alternative countermeasure analysis, the slope safety factors for the cross-section of the dam at STA 0+625 were 1.715 for upstream and 1.338 for downstream; at STA 0+641, 1.321 upstream and 1.306 downstream; and for the longitudinal section of the dam, 1.525. All these safety factors greater than 1.25, indicating that the slope is stable. In the second alternative countermeasure, the slope safety factors obtained for the cross-section of STA 0+641 were 1.362 for upstream and 1.386 for downstream, and 1.657 for the longitudinal section. These safety factors are also greater than 1.25, which indicates the slope is in stable condition. The additional cost for implementing the first alternative countermeasure is 73.9 million, while for the second alternative is 35.7 million. So that, the second alternative countermeasure is the best choice by the multi-criteria decision-making analysis results.
Peran Ayah (Fathering) terhadap Pengasuhan Balita
Authors: Suciawati Dewinta Tri , Sari Hera Ratna , Dewi Leni Puspita , Huriyah Fauziyah Syarifatul , Gandana Gilar
Published: June 2024

Seorang ayah yang berpartisipasi aktif dalam mengasuh anak memberikan kontribusi fisik, emosional, dan kognitif sehingga keterlibatan ayah dalam pengasuhan anak usia dini itu sangatlah penting. Tujuan dari penelitian ini yaitu untuk dapat melihat dan mengetahui peran ayah terhadap pengasuhan balita yang berada.  Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif dengan menggunakan kuesioner. Responden dalam penelitian ini adalah 20 ayah yang memiliki anak usia 1-5 tahun dan berada di wilayah Priangan Timur, Kab. Pangandaran, dan Ciamis. Hasil analisis data menunjukkan bahwa keterlibatan ayah dalam pengasuhan dapat dilakukan dengan cara menonton televisi dan berjalan-jalan, bermusyawarah dengan istri terkait permasalahan anak, memberikan contoh, dan memantau tumbuh kembang anak. Implkasi hasil penelitian ini dapat menjadi referensi bagi ayah untuk tetap terlibat dalam pengasuhan.
Tingkat Kesadaran Masyarakat Dalam Menjaga Lingkungan Di Era Pandemi Covid – 19 Di Kelurahan Warugunung, Kota Surabaya
Authors: Islamiyah Nurul Qur'ani , Ni'amah Mazida , Susanto Muhamad Azmi Dwi , Fitriah Nur Aini
Published: June 2024

Kesadaran masyarakat terhadap kondisi lingkungan sekitarnya masih sangat kurang, dikarenakan banyak masyarakat yang belum mengerti akan pentingnya menjaga lingkungan. Oleh sebab itu, banyak masyarakat yang masih membuang sampah tidak pada tempatnya, sehingga banyak limbah rumah tangga yang mencemari lingkungan. Pandemi Covid-19 merupakan salah satu momentum yang dapat menjadikan masyarakat Kelurahan Warugunung menjadi lebih mengenal lingkungan sekitar dan berpotensi besar untuk meningkatkan kesadaran masyarakat dalam menjaga lingkungannya. Penelitian ini menggunakan metode observasi lapangan untuk pengambilan data primer berupa kuesioner atau susunan pertanyaan yang diajukan kepada responden, dan pengambilan data sekunder diambil dari studi literature berupa dokumen tertulis maupun elektronik. Objek penelitian ini adalah seluruh warga di Kelurahan Warugunung yang memiliki range usia antara 15-50 tahun. Pengambilan sampel menggunakan rumus slovin dengan menghitung jumlah sampel minimal pada sebuah populasi dengan jumlah  besar. Upaya menjaga lingkungan disekitar rumah yang dilakukan masyarakat Kelurahan Warugunung dengan perilaku-perilaku sederhana seperti membuang sampah pada tempatnya, upaya pengolahan sampah, serta bercocok tanam, diketahui total dari keseluruhan tingkat kesadaran masyarakat dari tertinggi hingga terendah didapatkan sebanyak 55% melakukan, kedua didapatkan 27% meningkat, sedangkan pada urutan ketiga sebanyak 14% tidak melakukan, dan terakhir didapatkan 4% menurun.
Pengaruh gaya kepemimpinan terhadap pengambilan keputusan di desa Banjarbendo Kabupaten Sidoarjo
Authors: Ningrum Widya Lestiana , Sukmana Hendra
Published: June 2024

Penelitian ini memiliki tujuan untuk menggambarkan dan menganalisis dampak dari gaya kepemimpinan terhadap pengambilan keputusan di desa banjarbendo kabupaten sidoarjo. Penelitian ini menerapkan metode kuantitatif dalam pendekatannya untuk menganalisis data dalam bentuk angka-angka dan kemudian mengolahnya melalui perhitungan dan skor, serta melakukan analisis statistik untuk membuktikan hubungan antara variabel-variabel yang diamati Menganalisis dari dua tabel yang mencakup indikator gaya kepemimpinan dan kemampuan pengambilan keputusan Pengumpulan data melibatkan penggunaan data primer yang diperoleh dari penduduk desa Banjarbendo yang kemudian dijadikan responden menggunakan rumus slovin setelah melakukan perhitungan sehingga peneliti menyesuaikan sebanyak 377 responden dan untuk menguji data yang ada peneliti menggunakan uji validitas dan uji reabilitas untuk mengetahui hasil dari variabel gaya kepemimpinan dan pengambilan keputusan.Penelitian ini menunjukkan bahwa responden memberikan penilaian positif secara keseluruhan terhadap gaya kepemimpinan dan kemampuan pengambilan keputusan pemimpin mereka. Kemampuan mengendalikan emosi, tanggung jawab, dan kreativitas adalah indikator yang dinilai tertinggi. Namun, terdapat beberapa aspek yang mendapatkan penilaian lebih rendah, seperti kemampuan komunikasi dan gaya manajemen. Penelitian ini memberikan pandangan penting bagi pemimpin desa dalam mengembangkan keterampilan kepemimpinan dan kemampuan pengambilan keputusan yang lebih baik guna mencapai tujuan organisasi dalam memajukan Desa Banjarbendo.Kata kunci : gaya kepemimpinan; kemampuan pengambian keputusan; persepsi; pemimpin
Development of Leadership Skills in Medical Education: Protocol for a Scoping Review (Preprint)
Authors: Chubaci Eliana Fazuoli , Costa Carlos Dario da Silva , Santos Neto Martins Fideles dos , dos Santos Emerson Roberto , Engel Ana Maria Rita Pedroso Vilela Torres de Carvalho , Costa Ana Caroline dos Santos , Silva Taisa Morete da , Cristóvão Helena Landin Gonçalves , Quitério Alex Bertolazzo , Lima Alba Regina de Abreu , Brienze Vânia Maria Sabadoto , Fácio Jr Fernando Nestor , André Júlio César
Published: June 2024

BACKGROUND

Leadership is recognized as an essential competency in health care and science, being central for professionals to face health challenges. Few physicians feel prepared to serve as leaders in the health care environment, and few receive training in the leadership skills needed to be successful. Teaching leadership skills together with extensive, longitudinal, clinical education in an authentic and nurturing environment can effectively develop students for leadership in medicine. Studies on the subject still do not show the best way to implement it in medical education, and an updated review is necessary.

OBJECTIVE

The aim of this study is to identify the types of available evidence on the teaching of leadership skills in undergraduate courses in the health area, analyze them, determine knowledge gaps, and disseminate the research results.

METHODS

This is a scoping review that will consider studies on leadership skills in medical and health undergraduate courses. Primary studies published in English, Spanish, and Portuguese since 2019 will be considered. The search will be performed in 8 databases, and reference lists will be searched for additional studies. Duplicates will be removed, and 2 independent reviewers will examine the titles, abstracts, and full texts of the selected studies. Data extraction will be performed using a tool developed by the researchers.

RESULTS

The scoping review is currently in progress. The preliminary database search has been completed, yielding a total of 1213 articles across multiple databases. The next stages, including deduplication, title and abstract screening, and full-text review, are scheduled to be completed by December 2024. Data extraction and analysis are expected to be finalized by March 2025, with the final report anticipated to be ready for submission by June 2025.

CONCLUSIONS

This scoping review on leadership in the medical curriculum can significantly contribute to the literature by organizing and synthesizing the available evidence on teaching leadership skills in undergraduate courses in the health area. Furthermore, by analyzing evidence and identifying knowledge gaps, the study can provide valuable insights to develop more efficient and comprehensive medical education programs, thus preparing students to take on leadership roles in the complex environment of health care.

CLINICALTRIAL

Open Science Framework YEXKB; https://osf.io/yexkb

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/62810
G-CBT for Reducing Depression Symptoms in Individuals from Dysfunctional Family
Authors: Pramadani Arti , Retnowati Sofia
Published: June 2024

Individuals from dysfunctional family have various risks of mental health deterioration including depression. To solve this family problem actually it is the best to conduct family therapy to the family. But unfortunately not all dysfunctional family are willing to cooperate in family therapy. Therefore individual therapy is considered important to protect individual of dysfunctional family from depression. The aim of this research is to examine the effectivity of Gratitude Cognitive Behavior Therapy in reducing depressive simptoms in individuals from dysfunctional family. Method used in this research is single case quasy experiment with A-B-A design. Findings from this research tells us that G-CBT is efective in reducing depression in individuals from dysfunctional family. Participants get some positive effect of this intervention including wider perspective, ability to see other points of view, appreciate every positive little thing, acknowlede one’s strenght, and increase sense of gratitude to God.
Pelatihan Daring PLANS untuk Meningkatkan Kematangan Karier pada Siswa SMA Kelas XI
Authors: Ardhana Sephia Fitri , Ardiyanti Difa
Published: June 2024

Salah satu fenomena menarik yang terus diteliti pada siswa SMA adalah kurangnya kematangan karier, yang berakibat pada siswa merasa tertekan dengan tuntutan akademis dibidang yang kurang sesuai dengan dirinya sehingga memunculkan perasaan salah memilih jurusan dan berakhir dengan drop out. Oleh karena itu, siswa diberikan pelatihan daring PLANS untuk meningkatkan kematangan kariernya. Penelitian ini menggunakan jenis eksperimen kuasi untreated control group design with dependent pretest and posttestsamples dengan metode kuantitatif menggunakan dua alat ukur kematangan karier, yaitu skala sikap (r=0,859) dan tes kompetensi (r=0,615). Subjek penelitian berjumlah 18 siswa dengan skor kematangan karier sedang dan rendah. Teknik analisis yang digunakan adalah non-parametrik tes, yaitu uji Wilcoxon. Bedasarkan hasil analisis didapatkan nilai signifikansi skala sikap 0,008 (p<0,05) dan nilai signifikansi tes kompetensi 0,007 (p<0,05) menunjukkan adanya perubahan nilai skala sikap dan tes kompetensi yang signifikan dari skor pretest ke posttest antara kelompok eksperimen dan kontrol. Kesimpulannya adalah pelatihan daring PLANS dapat meningkatkan kematangan karier pada siswa SMA kelas XI.
Analisis Tingkat Akurasi Metode Pendeteksian Plagiarisme Ide dengan menggunakan Yake dan Sentence Transformer
Authors: Rahma Salsabila Laily , Taufiq Umar
Published: June 2024

Penggunaan Artificial Intelligence dengan teknik unsupervised learning dapat berguna dalam pendeteksian plagiarisme ide karena dapat mengidentifikasi kemiripan dan perbedaan antara dokumen teks tanpa memerlukan data berlabel atau pelatihan khusus. Plagiarisme ide melibatkan penyisipan ringkasan dari satu dokumen teks ke dalam dokumen teks lainnya, sehingga membuatnya sulit terdeteksi menggunakan metode pendeteksian plagiarisme standar. Metode yang dikembangkan dalam penelitian ini bertujuan untuk mengatasi permasalahan masalah dalam deteksi plagiarisme ide. Penelitian ini mengembangkan metode untuk deteksi plagiarisme ide dan menguji tingkat akurasi level dokumen dari metode yang dikembangkan. Metode yang dikembangkan ini menggunakan pendekatan baru dengan memanfaatkan library Python yang mengimplementasikan AI pada teknik unsupervised learning yaitu metode Yake sebagai algoritma pengekstrak kata kunci dan Sentence Transformer sebagai algoritma untuk menghitung kemiripan teks pada dataset PAN. Plagiarism Analysis, Authorship Identification, and Near-Duplicate Detection (PAN) adalah kumpulan data yang bersifat public dan secara khusus dikembangkan untuk penelitian dalam bidang pendeteksian plagiarisme. Dataset PAN yang digunakan dalam penelitian ini adalah dataset PAN13-14 summary obfuscation dengan sebuah ground truth yang menjadi acuan dalam pengukuran akurasi dari metode yang dikembangkan. Hasil penelitian menunjukkan bahwa metode Sentence Transformer dengan Yake pada threshold 0.1 memiliki akurasi tertinggi untuk kategori Plagiarized dengan nilai F-score pada dataset testing dan dataset training secara berturut-turut adalah 0.3175 dan 0.3217, sementara metode Sentence Transformer dengan threshold 0.6 memiliki akurasi tertinggi untuk kategori Non Plagiarized dengan nilai F-score pada dataset testing dan dataset training secara berturut-turut adalah 0.8905 dan 0.8907.
Developing Therapies for C3 Glomerulopathy
Authors: Nester Carla , Decker Dima A. , Meier Matthias , Aslam Shakil , Bomback Andrew S. , Caravaca-Fontán Fernando , Cook Terence H. , Feldman David L. , Fremeaux-Bacchi Veronique , Gale Daniel P. , Gooch Ann , Johnson Sally , Licht Christoph , Mathur Mohit , Pickering Matthew C. , Praga Manuel , Remuzzi Giuseppe , Selvarajah Viknesh , Smith Richard J. , Tabriziani Hossein , van de Kar Nicole , Wang Yaqin , Wong Edwin , Mistry Kirtida , Lim Mark , Portillo Cesia , Balogun Seyi , Trachtman Howard , Thompson Aliza
Published: June 2024

Randomized clinical trials are underway to evaluate the efficacy of novel agents targeting the alternative complement pathway in patients with C3 glomerulopathy (C3G), a rare glomerular disease. The Kidney Health Initiative convened a panel of experts in C3G to (1) assess the data supporting the use of the prespecified trial end points as measures of clinical benefit and (2) opine on efficacy findings they would consider compelling as treatment(s) of C3G in native kidneys. Two subpanels of the C3G Trial Endpoints Work Group reviewed the available evidence and uncertainties for the association between the three prespecified end points—(1) proteinuria, (2) eGFR, and (3) histopathology—and anticipated outcomes. The full work group provided feedback on the summaries provided by the subpanels and on what potential treatment effects on the proposed end points they would consider compelling to support evidence of an investigational product's effectiveness for treating C3G. Members of the full work group agreed with the characterization of the data, evidence, and uncertainties, supporting the end points. Given the limitations of the available data, the work group was unable to define a minimum threshold for change in any of the end points that might be considered clinically meaningful. The work group concluded that a favorable treatment effect on all three end points would provide convincing evidence of efficacy in the setting of a therapy that targeted the complement pathway. A therapy might be considered effective in the absence of complete alignment in all three end points if there was meaningful lowering of proteinuria and stabilization or improvement in eGFR. The panel unanimously supported efforts to foster data sharing between academic and industry partners to address the gaps in the current knowledge identified by the review of the end points in the aforementioned trials.
Analysis of the Communication Path of Ideological and Political Education for College Students Empowered by Smart Media
Authors: Zhang Yihan
Published: June 2024

As a crucial part of the entire education system, the dissemination of ideological and political education determines the success or failure of educational quality through its actual effectiveness. The arrival of the new media era has changed the way information is disseminated, reshaped the communication path and mode, and had a profound impact on the value choices and ideological behavior of college student audiences. Facing the group of young college students, the communication environment in the era of intelligent media is a new development space, creating opportunities for the dissemination of ideological and political education. In the face of changes in information dissemination methods and behavioral characteristics of college students, it is of great significance to explore innovative paths for the dissemination of ideological and political education in universities through the empowerment advantages of intelligent media.
Application and Exploration of Artificial Intelligence in Teaching and Learning in Private Colleges and Universities
Authors: Wang Peilian , Xie Hui
Published: June 2024

The rapid advancement of artificial intelligence technology across various sectors has sparked profound transformation in the field of education, particularly in the realms of pedagogy and administration within private higher education institutions. The discourse delves into the specific applications of AI educational aids in both classroom instruction and post-class learning, encompassing intelligent tutoring systems, virtual laboratories, and personalized learning recommendation systems, among others. Furthermore, it addresses the utilization of AI-driven question-answering systems, automated homework grading systems, and speech recognition technology. In terms of educational administration, it investigates the integration of intelligent student information systems, learning trajectory tracking systems, as well as course resource recommendation systems and teaching evaluation systems. The aim of the article is to furnish educators with valuable insights to enhance teaching quality and administrative efficiency, thereby promoting the intelligent development of private higher education institutions.
Profilaxis pre-exposición de VIH en hombres que tienen sexo con otros hombres y su influencia en otras enfermedades de transmisión sexual: una revisión bibliográfica
Authors: Vázquez-Gómez Silvia , Vázquez-Gómez Lorena
Published: June 2024

Introducción:
La profilaxis pre-exposición (PrEP) es una nueva estrategia de prevención contra la infección del virus de la inmunodeficiencia humana (VIH).

Objetivo:
Evaluar si el empleo de la PrEP aumenta el riesgo de adquirir otras infecciones de transmisión sexual (ITS) bacterianas en hombres que tienen sexo con otros hombres (HSH) con alto riesgo de adquirir la infección por VIH.

Metodología:
Fue realizada una búsqueda exhaustiva de artículos empleando las bases de datos PubMed, Scopus y Web of Science.

Resultados:
Entre los HSH usuarios de PrEP se produce un aumento en la incidencia de ITS bacterianas, debido en parte, a la realización de pruebas de ITS y VIH más asiduamente en comparación con otras poblaciones. Se determinó la presencia de una compensación del riesgo durante la PrEP.

Conclusión:
Los HSH pueden experimentar un aumento en la incidencia de ITS bacterianas durante el empleo de la PrEP en comparación al periodo previo sin tratamiento. La percepción de protección provoca que se minusvalore el riesgo de contraer otras ITS en las relaciones sexuales. La práctica de sexo anal sin preservativo y el sexo con múltiples parejas destacan como factores que aumentan el riesgo de adquirir ITS entre los usuarios de PrEP.
Analisis indeks glikemik snack bar berbahan dasar beras hitam dan kacang merah
Authors: Ayunandha Harentya , Sofyaningsih Mira , Safitri Debby Endayani
Published: June 2024

Consumption of snacks with high sugar and low fiber content can cause degenerative diseases at a young age. The purpose of this study was to formulate black rice which was converted into brood and red beans in the form of a snack bar that has a low glycemic index. This study used a completely randomized design with one red bean substitution treatment factor with levels of F0 (0%), F1 (10%), F2 (20%) and F3 (30%). The determination of the best snack bar uses an organoleptic test with semi-trained panelists and a food glycemic index test using the iAUC method. The results showed that the 30 g serving weight of the snack bar contained 140 kcal of energy, 4 g of fat, 2 g of protein, 22 g of carbohydrates, and 2 g of dietary fiber. In addition, the black rice and red bean snack bar has a glycemic index of 35.91% and a glycemic load of 7.9 which is included in the low category. Based on the blood glucose response curve, it shows that the snack bar of black rice and red beans causes glucose levels to tend to be stable and hypoglycemia after 2 hours of blood glucose sampling.