bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor metastásico en tejido blando a nivel del sacro secundario a carcinoma de células claras de riñón. Reporte de caso
Authors: O’Farril-Anzures Ricardo , Llamas-Ceras Martha Leticia , Pulido-López Ricardo Alberto , Romero-Sánchez Jorge Adrián
Published: August 2023

Introducción. El cáncer de riñón es la undécima neoplasia maligna más común en los Estados Unidos Mexicanos. El carcinoma de células claras de riñón (CCR) es considerado la estirpe más frecuente y representa el 2-3 % de todos los cánceres a nivel mundial. En el contexto de la enfermedad metastásica, por lo general se identifica un tumor renal primario y las metástasis se localizan en pulmón, hueso, hígado, cerebro y, raramente, en tejidos blandos. Los pacientes con metástasis a tejidos blandos no tienen síntomas en las etapas iniciales y generalmente se identifican sólo cuando las lesiones aumentan de tamaño o durante el estudio de la pieza de resección quirúrgica. Caso clínico. Se presenta el caso de una paciente en la séptima década de la vida, con una metástasis en tejidos blandos de la región sacra, de 10 años de evolución posterior a una nefrectomía secundario a CCR. Resultados. Hallazgos clínicos e imagenológicos de un tumor bien delimitado. Se realizó resección quirúrgica de la lesión, bajo anestesia regional, con extirpación completa. Conclusión. Se recomienda que los pacientes con un sitio metastásico resecable y solitario sean llevados a resección quirúrgica con márgenes libres, como fue el caso de nuestra paciente, por su fácil acceso y ser una lesión única. En el CCR, además de su tratamiento quirúrgico inicial, es indispensable una estrecha vigilancia con examen físico e imágenes transversales, para detectar la presencia de metástasis y con ello evitar tratamientos tardíos.
Tumor de cuerpo carotídeo en adolescente. Reporte de un caso
Authors: Miranda-Palta Rodrigo , Matamoros-Plaza Catalina , Araya Rodrigo , Cabané-Toledo Patricio
Published: August 2023

Introducción. Los paragangliomas del cuerpo carotídeo son neoplasias infrecuentes y representan el 0,6 % de los tumores de cabeza y cuello. La edad de presentación promedio es la quinta década de vida. El objetivo de este artículo fue describir un caso de paraganglioma del cuerpo carotídeo en una adolescente.
Caso clínico. Se presenta el caso de una paciente adolescente con paraganglioma de cuerpo carotídeo derecho, de 5x3x3 cm, Shamblin III. Se analizaron la historia clínica, los exámenes diagnósticos, la técnica quirúrgica utilizada y su evolución correspondiente. La información fue obtenida a partir de la ficha clínica, previa autorización por consentimiento de los padres de la paciente.
Resultados. Se hizo resección quirúrgica completa y reparo vascular con injerto de vena safena invertida, con evolución favorable y permeabilidad completa del puente vascular, sin secuelas.
Conclusión. Este caso podía corresponder a un tumor de etiología familiar, dada su edad temprana de presentación. Se hizo necesario complementar su estudio con imágenes y objetivar el compromiso vascular asociado para la planificación quirúrgica. En estos pacientes, la complejidad de su localización y el compromiso vascular del tumor requiere de un equipo multidisciplinario, con cirujanos de cabeza y cuello y cirujanos vasculares para un resultado exitoso.
Dilemma to Dominance: Decoding the Evolution of the Indian Pharmaceutical Industry - A Case Study
Authors: Anushree Bose  , Dr. Rajesh K. Pandey
Published: August 2023

The Indian pharmaceutical industry has undergone a significant evolution, transitioning from a domestically-focused sector to a global powerhouse. Initially, Indian pharmaceutical companies primarily catered to domestic healthcare needs. However, with the implementation of economic reforms in the 1990s, the industry witnessed rapid growth and expanded into international markets. The Indian pharmaceutical industry has experienced a remarkable transformation, establishing itself as a global leader in the production and export of generic drugs. The industry has demonstrated superior growth performance, making it one of the fastest-growing sectors worldwide. Productivity levels and innovation play a significant role in determining competitiveness, and the Indian pharmaceutical industry has shown impressive capabilities in these areas. Government policies have been instrumental in driving the industry's self-sufficiency and internationalization. The establishment of public sector pharmaceutical enterprises and the introduction of intellectual property regulations, pricing control, and research and development (R&D) support have propelled the industry's growth.

This case study aims to provide an in-depth analysis of the journey of the Indian pharmaceutical industry, exploring its growth, challenges, and the dilemma it faces in balancing innovation and affordability. By examining the sector's perspective, challenges, and identified dilemmas, this case study aims to equip readers with a comprehensive understanding of the industry. The case delves into the journey and challenges faced by the Indian pharmaceutical industry. It investigates the industry's growth, the perspective of Indian pharmaceutical companies, the challenges they encounter, and the identified dilemmas. The case also provides teaching notes and objectives to enhance the readers' knowledge and decision-making skills within the pharmaceutical industry.
Investment Project Selection with Multi Criteria Decision Making Techniques in FMCG Industry
Authors: Özge YIKICI  , Tijen Över ÖZÇELİK
Published: August 2023

In today's our modern world, where rivalry is increasing from day to day and technological developments are advancing very fast, decision-making processes are becoming more difficult. Especially for companies, investment projects are a critical decision-making problem due to their huge budgets and their impact on the company. Therefore, making decisions by utilizing scientific methods is of the essence for companies.
Related in the thesis, it is determined to select the most optimum project for the company to invest in a leading company in the FMCG sector based on a project selection problem with 5 main criteria, 8 sub-criteria and 5 alternatives.
In problem solving, AHP, which is the most widely utilized method for weighting criteria in the literature, and TOPSIS, VIKOR, which are the most typically used methods in project selection in the literature, and ARAS method, which is rarely used, were used to address the project selection problem. Since ARAS method studies are impreplance in the literature, it is purposed to fill gap in this thesis is supported by Fuzzy AHP and Fuzzy TOPSIS procedures. In the thesis, it was make firm that the ARAS method, which is scarce used in the literature, works in harmony with the widely used AHP, TOPSIS and VIKOR procedures.
With this work;
It is forecast that companies can use these mathematical methods to enable decision making in cases involving many criteria and alternatives.
This application in the FMCG sector, where project selection decisions are frequently made, has brought a academic approach to investment project selection problems.
The use of AHP, BAHP in project criteria weighting; TOPSIS, Fuzzy TOPSIS, VIKOR and ARAS methodologies in project selection has make a help to the literature and proved that the methods work in concord with one together. It is estimated that these mathematical modeling can be used in particular decision-making trouble of the company.
Telenursing Applications in Treatment Compliance among Patients with Mental Disorders
Authors: Mamnuah Mamnuah , Trihidayat Noorwahyu , Isnaeni Yuli
Published: August 2023

Background: Treatment adherence is one of the problems in the treatment of patients with mental disorders. Telenursing is a part of telemedicine that plays an important role in providing modern nursing care, improving the quality of care, and accessing services quickly. Purpose: To describe the use of telenursing in medication adherence in patients with mental disorders. Methods: Literature review searches were conducted on PubMed, Wiley, and Google scholar. The search strategy used the keywords "telenursing" OR "telehealth" AND Medication Adherence" AND "Mental disorder". The inclusion criteria are the article uses a Randomized Control Trial design, the article does not limit the place or location, published in the last 5 years (2017-2021), in English and free full text. While the exclusion criteria are qualitative research, mixed-method, journal review/systematic review, published under 2017, the title and abstract do not match. Results: Four articles matched the inclusion criteria and topics. From four articles, it was found that the application of telenursing in mental disorders uses TIPS (Telephone Intervention Problem Solving), LEAN (Lay health supporters, E-platform, Award, and iNtegration), cellular applications such as WhatsApp, WeChat, Telegram, Line. Conclusion: With a smartphone application, it can provide a signal, reminder, or education, in overcoming forgetting or not wanting to take medicine or forgetting to control schedules and can be adjusted to resource and geographical conditions. The use of telenursing can help people with mental disorders to increase their belief in the importance of treatment, increase treatment adherence, reduce the length of hospital stay.
Effects of Complementary Alternative Medicine on Hyperemesis Gravidarum: A Systematic Review
Authors: Kundarti Finta Isti , Titisari Ira , Rahayu Dwi Estuning
Published: August 2023

Background: Nausea and vomiting of pregnancy (NVP) is a common problem for pregnant women. Many pregnant women are worried about the side effects of pharmacological therapy, thus encouraging them to use non-pharmacological therapy. Researchers have recently paid particular attention to complementary medicine methods for the treatment of NVP. With regard to the high prevalence of NVP as well as the adverse effects of chemicals on the mother and fetus of the drug, this study focused on assessing the safety and efficacy of different non-pharmacological methods in eliminating NVP. This systematic review was carried out to assess the safety and efficacy of different non-pharmacological methods in eliminating NVP. Methods: This study used a systematic review method by conducting a literature search through the PubMed database, Cochrane library, Science direct, Proquest, and Google Scholar with publication years starting January 2011 and January 2021. Results: A total of ten articles were selected as part of the final sample according to the inclusion criteria. Of the 10 articles, 2 were about the use of ginger, 3 were about Acupuncture-moxibustion, 2 were about psychotherapy, one was about Progressive muscle relaxation, and 2 were about psychoeducation. Studies have shown a positive effect on NVP reduction; however, no side effects were reported. Conclusion: According to the results of this review, most of the methods used are effective in reducing the incidence of NVP, among which ginger and P6 acupressure can be recommended more reliably.
Effect of Childbirth Education Program on Maternal Anxiety: A Randomized Controlled Trial Using Roy's Adaptation Model
Authors: Suryaningsih Endang Koni , Gau Meei-Ling , Kao Chien-Huei , Liu Chieh-Yu , Kuo Su-Yu , Liaw Jen-Jiuan
Published: August 2023

Background: Globally, 5.1 - 37.5 % of mothers suffer from anxiety during pregnancy due to adaptation problems. Childbirth education could enhance knowledge and skills to help mothers prepares to cope with adaptation. However, in Indonesia, the manner program provided following nursing theory as a framework has been absent.
Objective: To test the effectiveness of childbirth education program based on Roy's Adaptation Model on maternal anxiety
Methods: A randomized controlled trial using a computer random allocation block to allocate participants from five health centers in Yogyakarta has been performed. Pregnant women in the experimental group received a modified childbirth education program in four consecutive weeks comprised of lecturing, counseling, brainstorming, and practicing some essential skills for cope adaptation. A self-developed questionnaire was used to assess the demographic data set, Pregnancy-Related Anxiety Questionnaire-Revised was completed to measure the maternal anxiety during pregnancy. An independent t-test and ANCOVA were used to analyze the data. 
Results: A total of 87 pregnant women were analyzed (experimental, n= 52, control, n=35), with a mean age of 23. 92 (SD = 1.89), and 29.14 (SD = 2.10), respectively. After the intervention, the score of maternal anxiety had significantly lower in the experimental group compared with the control group (p < .001). In the T-test analysis, the demographic variables were not related to maternal anxiety.
Conclusion: Based on the findings, a modified childbirth education program focus on adaptation change based on nursing theory was effective to decrease maternal anxiety during pregnancy. However, what  the participant perceived in the prenatal education program is one of the salient limitations in this study.
Content: A Possible Key to Consciousness
Authors: Clark Thomas W
Published: August 2023

A first order of business in explaining consciousness is to make sure it’s consciousness that’s being explained. I argue that there are two essential features of consciousness needing explanation: qualitativeness – the sensory feel of experience – and subjectivity: that experiences exist only for the conscious subject. These constitute what’s called phenomenal consciousness or phenomenality. I argue that we should be realists, not illusionists, about phenomenality, even if this poses explanatory difficulties for standard science. Although some advise that we should focus on the structure of experience in relation to its neural correlates, I suggest that the primary explanandum confronting theories of consciousness is not its structure, nor its associated functions, but its qualitative and subjective nature. The bulk of the paper defends what I call the content hypothesis as an approach to explaining phenomenality. Getting a fix on the nature of representational content may be key to understanding both subjectivity and qualitativeness. Content, although real, is not available to observation as are its physically instantiated vehicles; thus, understanding the qualities of experience as a species of content may help account for its subjectivity. Qualitativeness itself might be understood as an entailment of a representational system’s need for basic content items – epistemic primitives – that are not themselves objects of representation. Basic sensory qualities can be construed as the content of such primitives. Progress in understanding the functional and ontological status of content, as for example in the predictive processing paradigm, may suggest why, as a matter of representational necessity, systems like ourselves host conscious experience.
A Bayesian hierarchical modeling approach of person and item features that contribute to response bias
Authors: Lima-Costa Ariela Raissa , Franco Víthor Rosa , Araujo Bruno Bonfá , Zuchetto Samanta Romanin , Hauck-Filho Nelson
Published: August 2023

Traditionally, extreme responding has been recognized as a bias in which individuals tend to select the highest or lowest response categories on self-report items, regardless of item content. This bias is believed to occur independently of the desirability of the trait or state described in the item statement. However, little effort has been made to empirically test this assumption. In this study, we propose a novel approach to control for both extreme (ERS) and socially desirable responding (SDR) in self-report questionnaires. We considered judges' ratings of item social desirability to control for SDR by employing Bayesian hierarchical and joint modeling. We also considered the effect of ERS to be multiplicative rather than additive, assuming a noncompensatory role to ERS. The advantage of this approach is mostly computational. Overall, our results indicate that modeling the impact of ER improved the model fit on measures of affect and pathological traits. However, contrary to expectations, our analysis did not indicate any substantive influence of social desirability on items’ difficulty. In conclusion, our findings favor the perspective of both ER and social desirability as true traits rather than merely nuisance factors, evidence that our approach may assist researchers in gaining a deeper understanding of response biases in self-report items.
A Computational Method to Reveal Psychological Constructs from Text Data
Authors: Herderich Alina , Freudenthaler H. Harald , Garcia David
Published: August 2023

When starting to formalize psychological constructs, researchers traditionally rely on two distinct approaches: The quantitative approach, which defines constructs as part of a testable theory based on prior research and domain knowledge often deploying self-report questionnaires, or the qualitative approach, which gathers data mostly in the form of text and bases construct definitions on exploratory analyses. Quantitative research might lead to an incomplete understanding of the construct, while qualitative research is limited due to challenges in the systematic data processing, especially at large scale. We present a new computational method that combines the comprehensiveness of qualitative research and the scalability of quantitative analyses to define psychological constructs from semi-structured text data. Based on structured questions, participants are prompted to generate sentences reflecting instances of the construct of interest. We apply computational methods to calculate embeddings as numerical representations of the sentences, which we then run through a clustering algorithm to arrive at groupings of sentences as psychologically-relevant classes. The method includes steps for the measurement and correction of bias introduced by the data generation, and the assessment of cluster validity according to human judgment. We demonstrate the applicability of our method on an example from emotion regulation. Based on short descriptions of emotion regulation attempts collected through an open-ended situational judgment test, we use our method to derive classes of emotion regulation strategies. Our approach shows how machine learning and psychology can be combined to provide new perspectives on the conceptualization of psychological processes.
Working memory supports rapid talker and accent accommodation: An individual differences investigation
Authors: McLaughlin Drew Jordan , Teuscher Grace , Baese-Berk Melissa , Van Engen Kristin J.
Published: August 2023

Under multi-talker listening conditions, listeners appear to rapidly accommodate variability in speaker productions. However, evidence indicates that this trial-to-trial accommodation incurs a processing cost and is amplified by accent differences among talkers. The present study investigated how individual listener differences in working memory capacity and attentional control may predict the degree of processing costs (as measured by response time and accuracy) incurred by trial-to-trial switches in English talkers of first language (L1) American accent and second language (L2) Mandarin Chinese accent. Listeners completed a dual-task experiment with a primary listening task and secondary non-linguistic task as well as measures of working memory capacity (the Word Auditory Recognition and Recall Measure) and attentional control (the Trail Making Test and a Stroop Test). Results indicated that, on trials with a talker switch, listeners with smaller working memory capacities were slower to respond to the secondary task and had poorer recognition accuracy for the primary task. The measures of attentional control did not predict switching costs, but Stroop test scores did interact with the accent manipulation such that listeners with better attentional control had better overall recognition accuracy for L2 accent. Working memory capacity, on the other hand, did not predict differences in recognition accuracy between the L1 and L2 accent conditions. We conclude that working memory plays a critical role in supporting rapid (trial-to-trial) talker and accent accommodation. Attentional control appears to support processing of L2 accent more generally, but may not be critical for rapid accommodation. We discuss implications for active control and auditory streaming frameworks of speech processing.
The attribution of two items from the collection of D.G. Messerschmidt in the museum collection of the MAE RAS
Authors:   Peter the Great Museum of Anthropology and Ethnography (the Kunstkamera) of the Russian Academy of Sciences, Yemelina Olga
Published: August 2023

Dr. Daniel Gottlieb Messerschmidt by decree of Peter the Great undertook a seven-year journey (1719–1727) to Siberia with the aim of comprehensive scientific study of the region. The Siberian collections including a collection of antiquities entered the Museum in 1728. Some of the collections of D.G. Messerschmidt were damaged in the fire of the Kunstkamera in 1747, the remaining ones were redistributed to different museums. At present time the drawings from Messerschmidt’s work “Sibiria perlustrata” and a catalog of watercolor drawings of the artifacts stored in the Kunstkammer made at the Academy of Sciences in the 1730s–1740s are used as sources for the study of archaeological objects. The article discusses the experience of attribution of two items from the collection of D.G. Messerschmidt. The analysis of the images in Messerschmidt’s work “Sibiria perlustrata” and catalog 1730–1740 during the preparation of the exhibition “Kunstkamera of Peter the Great, or the Tower of Knowledge” were used as a proxy sources to select the closest archaeological artifacts to the Messerschmidt originals. Among others are two small Turkic stirrups from the collection MAE No 1575. The collection consists of undocumented artifacts received by MAE in different time. Size, visual similarity and other characteristics made it possible to intensifier the stirrups from the collection MAE No 1575 as belonging to the Messerschmidt collection.
Policing, Lethal Force, and the Struggle for Equal Treatment: The Doug Purvis Memorial Lecture
Authors: Gillezeau Rob
Published: August 2023

La présente allocution, la conférence à la mémoire de Doug Purvis, présentée en juin 2022 à l’occasion du 56e congrès annuel de l’Association canadienne d’économie, se penche sur l’évolution de l’utilisation de la force mortelle au cours du siècle dernier et les vagues de protestation en réponse à cette violence. Elle se concentre en particulier sur les facteurs de causalité sous-jacents à l’augmentation rapide du nombre de décès de civils dans les années 1960-1970 et après 2008. S’agissant de la première période, les principaux facteurs de causalité sont la négociation collective, la militarisation et probablement le rôle croissant du gouvernement fédéral dans l’application de la loi, alors que l’augmentation de la diversité contribue à atténuer ces facteurs. En ce qui concerne le pic de violence policière après 2008, cette contribution analyse les causes potentielles, en particulier la militarisation, l’engagement civil croissant et la polarisation, ainsi qu’un large éventail de politiques d’atténuation. En ce qui a trait au rôle des protestations, les soulèvements contre la violence policière dans les années 1960 et 1970 ont entraîné des coûts communautaires importants, une diminution du soutien politique à la réforme de la police et une augmentation des niveaux de violence policière à l’encontre des civils. En revanche, les manifestations du mouvement « Black Lives Matter » d’aujourd’hui conservent un appui solide du public et entraînent une baisse significative de l’utilisation de la force mortelle. Cette allocution se termine par une discussion sur les options politiques et les recommandations à l’intention des gouvernements, des services de police et des manifestants dans le but de réduire l’utilisation de la force létale aux États-Unis et au Canada.
Identification and Portraits of Open Access Journals Based on Open Impact Metrics Extracted from Social Activities
Authors: Wei Quan , Mingkun Wei , Danyang Li , Savage Russell
Published: August 2023

This article focuses on open impact metrics extracted from social media activities that demonstrate the identification and portraits of open access journals based on these alternative forms of open impact metrics. The research sample consists of open access journals from Scopus, with open impact metrics retrieved from Altmetric.com . The open impact metrics extracted from social activities established that an evaluation system based on altmetrics can better reflect the portraits of open access journals than traditional citation-based metrics. This study finds that open access journals strengthen international academic communication and cooperation, build cross-border and cross-regional knowledge-sharing projects, realize the knowledge of interdisciplinary sharing and exchange, and, most importantly, provide a one-stop service for readers. This research indicates that through the use of open impact metrics, it is possible to identify the portraits of open access journals, thus providing a new method to construct and reform open access journal evaluation systems.
Determining Sexual Development and Size at Sexual Maturity of Sardinella tawilis and its Implications on Management
Authors: Pardo Kristyl Ckaye , Ticzon Victor , Camacho Ma. Vivian
Published: August 2023

Reproductive biology is important in formulating management interventions for fish stocks. Limits on catch size are established based on the identified size at first sexual maturity of the target fish species, which can be accurately determined through histological analysis of gonads. The study investigated the reproductive characteristics of the endangered Sardinella tawilis and determined the size at first sexual maturity based on histological analysis. Between 2017 and 2018, 312 fish samples with different lengths were collected in Taal Lake's northern and southern basins. The length-weight relationship of S. tawilis shows that the species exhibits negative allometric growth. Female S. tawilis, characterized by larger sizes, are significantly more abundant in our catches than male individuals (mean sex ratio p<0.05) and exhibit an asynchronous oocyte development. Histological analysis of gonads showed that the size at sexual maturity for both male and female S. tawilis were at 75 to 79 mm FL, which was smaller than the reported size at sexual maturity based on morphological analysis. Smaller average and maximum lengths, as well as the size at first sexual maturity, could suggest that S. tawilis has experienced growth overfishing and a slowly degrading lake environment through time. Results highlighted the importance of ensuring that immature S. tawilis can enter sexual maturity and contribute to the population through reproduction. It is also highly recommended that the size of S. tawilis to be targeted by fisheries are individuals above 100 mm FL, which exhibited the highest proportion of spawning capable individuals.
Phenotypic Variability in Dorsal-fin Rays of Rachycentron canadum
(Linnaeus, 1766) from Western, Visayas, Philippines
Authors: Cabebe-Barnuevo Roxanne , Penuela Dianne Frances , Mediodia Dominique , Babaran Ricardo , Malay Maria Celia
Published: August 2023

Cobia, Rachycentron canadum, is the only species in the family of Rachycentridae. Cobia is typically characterized as having 26–33 dorsal-fin rays. However, an investigation of specimens collected from Western Visayas waters revealed a wider variation in dorsal-fin ray count than previously reported, with some specimens having 35–36 dorsal-fin rays. Suspecting a possible cryptic species, we compared the mitochondrial cytochrome oxidase subunit 1 (COI) sequence for specimens with 35–36 dorsal-fin rays with those having the more typical 26–33 dorsal-fin rays. The sequences revealed no genetic differences between the two morphs. Morphometric measurements and meristic counting likewise found no significant differences. This is the first report of phenotypic variability in the dorsal-fin rays in Cobia. As a result of the phenotypic and genotypic characterization presented in this work, fisheries scientists and ichthyologists will be more aware of the existence of phenotypic variability in Cobia.
How is Mediation Integrated into the Dispute Resolution System of Civil Cases in Hungary?
Authors: Harsági Viktória
Published: August 2023

The article deals with the integration of mediation into the Hungarian justice system, with particular attention to its historical aspects, the connection between litigation and mediation and the conditions for becoming a mediator, as well as the two types of mediation.
Dampak Social Media Marketing dan Online Customer Review dalam Meningkatkan Purchase Intention melalui Customer’s Trust pada Pengguna Produk Ms Glow
Authors: Oktaviana Annisa , Saputra Murry Harmawan , Rahmawati Fitri
Published: August 2023

Pertumbuhan ekonomi yang seiring dengan perkembangan teknologi menjadikan internet sebagai salah satu media yang digemari masyarakat. Internet memudahkan proses komunikasi dan periklanan yang bertujuan untuk mengajak orang atau konsumen agar tertarik untuk membeli produk yang ditawarkan melalui jejaring media sosial. Salah satu strategi untuk meningkatkan minat beli adalah dengan social media marketing dan online customer review sehingga terciptanya customer’s trust dan akan berdampak pada purchase intention. Tujuan dari penelitian ini adalah untuk menguji pengaruh social media marketing dan online customer review terhadap purchase intention melalui customer’s trust. Sampel pada penelitian ini adalah 125 konsumen MS Glow di Purworejo. Pengambilan sampel menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan menggunakan kuesioner dan analisis menggunakan hierarchical regression analysis. Hasil penelitian ini menunjukkan bahwa social media marketing dan online customer review berpengaruh positif dan signifikan terhadap purchase intention, social media marketing dan online customer review berpengaruh positif dan signifikan terhadap trust. Kemudian customer’s trust berpengaruh positif dan signifikan terhadap purchase intention. Selain itu, social media marketing dan online customer review berpengaruh positif dan signifikan terhadap purchase intention yang dimediasi oleh customer’s trust, dalam hal ini berupa mediasi sebagian (partial mediation).
Clinical case of late diagnosis of hereditary microspherocytosis
Authors:   Republic Clinical Hospital, KUNST M. A. , KOSTERINA А. V. ,   Kazan State Medical University, ISKHAKOVA N. V. ,   Kazan State Medical University
Published: August 2023

Hereditary spherocytosis is a congenital hemolytic anemia, with an autosomal dominant type of inheritance, characterized by a violation of the structure of the erythrocyte membrane (microspherocytosis), increased osmotic fragility of erythrocytes, excessive destruction in the vasculature of the spleen, with a pronounced favorable response to splenectomy. Excessive destruction of red blood cells leads to anemia, reticulocytosis, hyperbilirubinemia (due to the indirect fraction) followed by cholelithiasis. The factor that aggravates the course of microspherocytosis is folate deficiency, which can appear both in people with limited nutrition and in pregnant women.
A case of acute myocardial infarction in a young patient with a newly diagnosed nephrotic syndrome
Authors:   Kazan State Medical University, MAKSUDOVA A. N. , KHALFINA T. N. ,   Kazan State Medical University, NURULLINA G. I. ,   Kazan State Medical University, FAKHRUTDINOVA O. YU. ,   Republic Clinical Hospital, ISLAMOVA G. M. ,   Republic Clinical Hospital, KHIDIYATOVA A. F. ,   Kazan State Medical University, LEVINA S. M. ,   Kazan State Medical University, KOKORINA YU. A. K ,   Kazan State Medical University
Published: August 2023

Thromboembolic complications in nephrotic syndrome (NS) are frequently encountered in the practice of a nephrologist and in many cases determine the course and outcome of diseases. The article presents a clinical case of acute ST-segment elevation myocardial infarction with Q tooth of posterior basal, lateral localization in a 36-year-old patient with a newly diagnosed nephrotic syndrome. In the young patient without a history of cardiovascular risk factors, coronary angiography revealed signs of progressive atherosclerotic stenosis of the coronary arteries, and the cause of MI was thrombotic occlusion of the enveloping branch of the left coronary artery. This clinical case required a more detailed study; the examination revealed a set of factors that led to MI in this young patient.
Clinical case of infliximab induction in a patient with Crohn’s disease and acute new coronavirus infection
Authors:   Kazan State Medical University, MUKHAMETOVA D. D. , BODRYAGINA E. S. ,   Kazan State Medical University, ODINTSOVA A. KH. ,   Republic Clinical Hospital, KUPKENOVA L. M. ,   Kazan State Medical University, SHAFIKOVA D. F. ,   Kazan State Medical University, FONTENELLE B. M. ,   Kazan State Medical University, ABDULGANIEVA D. I. ,   Kazan State Medical University
Published: August 2023

The article presents a clinical case of a new coronavirus infection in a patient with CD. The onset of the viral infection occurred during severe exacerbation of CD, what led to induction of infliximab therapy. The difficulty of managing patients with COVID-19 and immunoinflammatory diseases is discussed.
Sharpe’s syndrome: from basic anti-inflammatory therapy to genetically engineered biological drugs
Authors:   Kazan State Medical University, SHAPOREVA K. R. , LAPSHINA S. A. ,   Kazan State Medical University, SUKHORUKOVA E. V. ,   Republic Clinical Hospital, GARAEVA A. R. ,   Kazan State Medical University, ABDRAKIPOV R. Z. ,   Republic Clinical Hospital, ABDULGANIEVA D. I. ,   Kazan State Medical University
Published: August 2023

This article presents a clinical case of a patient with a mixed connective tissue disease. The clinical picture in the debut was polymorphic, the patient had arthritis, skin lesions, general inflammation, myopathy, Raynaud’s syndrome, dysphagia, angio-neurotic edema. The immunological panel reflected the presence of antibodies characteristic of autoimmune diseases (antinuclear antibodies, antibodies to ribonucleoprotein, antimitochondrial antibodies, antibodies to cytoplasmic antigen SS-B). Glucocorticosteroids (GCS), immunosuppressive drugs (metatrexate, sulfasalazine, hydroxychloroquine, azathioprine) were used as starting therapy, but the disease progressed. Pulse therapy of GCS and plasmapheresis did not give a positive result. We used Rituximab, because the pathogenesis of the disease was characterized by the activation of B-cells. Currently, two infusions have been performed, positive dynamics has been noted. Thus, the therapy of mixed connective tissue disease creates many diagnostic and therapeutic problems in clinical practice.
Clinical case of subcutaneous calcification in a patient with dermatomyositis
Authors:   Kazan State Medical University, SHAFIGULLINA A. A. , KIRILLOVA E. R. ,   Kazan State Medical University, SUKHORUKOVA E. V. ,   Republic Clinical Hospital, ABDRAKIPOV R. Z. ,   Republic Clinical Hospital
Published: August 2023

The article presents a clinical case of a patient with subcutaneous calcification. Deposits of calcium salts in the skin and subcutaneous fat can be a manifestation of a number of diseases. The article describes the characteristics of the clinical course of the disease and the laboratory and instrumental diagnostic methods. Judging by the dynamics of changes in the skin and subcutaneous fat, the presence of an immuno-inflammatory disease in the anamnesis, slow progression against the background of immunosuppressive therapy, the diagnosis was made: low activity dermatomyositis (as an outcome of juvenile dermatomyositis) with lesions of skin and muscles in the anamnesis. It should be noted that subcutaneous calcification is more characteristic for juvenile dermatomyositis.
Hydromyelia: evolution of ideas and diagnostic criteria
Authors:   Kazan State Medical University, MENDELEVICH E. G. , KURBANOVA A. A. ,   City Clinical Hospital No. 7
Published: August 2023

The article presents a review of literature devoted to a variant of cavity formation in spinal cord — hydromyelia. The authors review the history of studying the issue referring to the central canal expansion and list the main theories of hydromyelic cavities formation based on anatomical ideas about the central canal structure and functioning. The review describes the criteria of hydromyelic cavities diagnosis, clinical and MR-tomographic course of hydromyelia. In addition, cases of hydromyelia combination with other pathological conditions are presented.
Etiological and pathogenetic mechanisms of forming muscle dystonias
Authors:   Kazan State Medical University, MUNASIPOVA S. E. , ZALYALOVA Z. A. ,   Kazan State Medical University, TEREKHOVA A. A. ,   Kazan State Medical University
Published: August 2023

This article discusses the issues of muscular dystonia pathogenesis that are relevant to modern medicine, as well as the possibility of using the pathogenetic concept as a substrate to supplement the classification criteria. Reviewing the international publications on etiopathophysiology, genetics and classification, the article summarizes the main mechanisms for the occurrence of a pathological process at different levels of the nervous system. Despite the frequent clinical similarity of the symptoms of various forms of muscular dystonia, these symptoms may be the result of dysfunction of completely different genetic and neurophysiological mechanisms. The article focuses on the importance of studying the etiological and pathogenetic mechanisms and their further implementation in clinical practice in order to develop more accurate treatment techniques aimed at eliminating the specific causes of the development of specific forms of muscular dystonia.
Drug-induced lupus erythematosus
Authors:   Family Health LLC, KHADIEVA E. I. , YAKUPOVA S. P. ,   Kazan State Medical University, ABDRAKIPOV R. Z. ,   Republic Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, ZHURAVLEVA N. V. ,   I.N. Ulyanov Chuvash State University
Published: August 2023

This article presents a clinical case in which a patient observed by neurologists with a diagnosis of neuropathy and treated with anticonvulsants and antidepressants developed new clinical manifestations and laboratory changes characteristic of systemic lupus erythematosus. A clinical version emerged that the neurological changes were the disease onset, followed by the development of the remaining clinical and laboratory symptoms (the diagnosis fully met the 2019 EULAR criteria — a score of 16 points, 10 points are sufficient to make a diagnosis). However, after a very short and low-dose therapy with methylprednisolone and hydroxychloroquine and withdrawal of anticonvulsants, there was a rapid recovery of specific antibodies and improvement of clinical symptoms, which allowed assuming drug-induced lupus erythematosus in this patient. Currently, the list of drugs that can cause this problem includes more than 100 drugs.
Screening diagnostics of posture in persons involved in rhythmic gymnastics according to computer-optical topography
Authors:   Kazan State Medical University, BIKCHURIN N. M. , TAKHAVIEVA F. V. ,   Kazan State Medical University, RADCHENKO O. R. ,   Kazan State Medical University, AKISHIN E. M. ,   Republic Clinical Hospital
Published: August 2023

The purpose — to study the features of posture in persons involved in rhythmic gymnastics according to computer optical topography (COT) in three planes. Material and methods. Screening examination of posture by computer optical topography in 253 girls involved in rhythmic gymnastics (mean age 14.1 ± 1.7 years). The control group consisted of students of a comprehensive school not involved in sports — 57 girls (average age — 15.04 ± 1.5). Results. A high proportion of persons with posture disorders and spinal deformity was revealed both in the group of female gymnasts and in the comparison group: 86.16% and 85.95%, respectively. When assessing the horizontal and sagittal plane, disorders are more frequent among gymnasts. Posture disorders in the frontal plane are more common in persons not involved in rhythmic gymnastics. Significant differences were noted in the sagittal plane, where posture disorders were significantly more common in female gymnasts — in 55.74% compared to the control group — 40.35% (φemp = 2.094; α ≤ 0.05), and a subnormal variant was detected in 35.57% of gymnasts, while in the control group this value is significantly higher — 50.87% (φemp = 2.114; α ≤ 0.05). Conclusion. The use of COT allows for timely screening and diagnosis of the spine in order to develop preventive measures in youth sports.
Biodex diagnostic complex for prevention of injuries in athletes
Authors:   Kazan State Medical University, BORISOVA A. V. , TAKHAVIEVA F. V. ,   Kazan State Medical University, BUTOVSKY M. S. ,   Kazan State Medical University
Published: August 2023

The purpose — to determine the strength of thigh muscles with maximum muscle workout of extension and flexion in football players of a youth football league. Material and methods. The study group included 60 athletes of a youth football league aged 14–17 y. o. They were examined on a Biodex 4 Pro robotic complex, flexion and extension of knee joints alternately at a speed of 60 º/sec and 180 º/sec. Results. The greatest deficit between the lower extremities was found when the knee joint was extended at 60 °/sec and amounted to 19.33%. When the knee joint was flexed at 60 °/sec, the deficit between the limbs was 10.4, which is acceptable, but requires correction. When bending the knee joint at a speed of 180 °/sec, the deficit of muscle strength was 12%, which is also an additional risk factor for injury when working for «endurance». When bending at a speed of 180 °/sec, the deficit was minimal and amounted to 4.3%, which is a variant of the norm. Conclusion. In young football players, the maximum deficit of muscle strength was observed between the extremities with maximum muscle workout in extension by 60 °/sec and by 180 °/sec, which is an additional risk factor for getting muscle damage in the hip and injuries to the capsule-ligamentous apparatus of the knee joint, both when working in the gym and on the field when performing specific work. The research showed that this assessment method is objective and can be used to develop prophylaxis measures and in rehabilitation programs for football players.
Features of cognitive functions in patients with essential tremor
Authors:   Kazan State Medical University, ZALYALOVA Z. A. , MUNASIPOVA S. E. ,   Kazan State Medical University, ERMAKOVA M. M. ,   Kazan State Medical University
Published: August 2023

Essential tremor (ET) is the most common movement disorder, the main manifestation of which is progressive postural-kinetic tremor of the extremities, the pattern most often involving the hands. According to the latest classification, 2 different groups of patients with essential tremor are distinguished: patients with tremor (ET) and patients in whose clinic there are additional symptoms in addition to tremor (ET-plus syndrome, ET-P). The purpose was to identify and compare cognitive impairment in patients with essential tremor and essential tremor plus syndrome. Material and methods. A prospective study of 41 patients with essential tremor was performed at the Center for Movement Disorders and Botulinum Therapy of the Republic of Tatarstan using clinical, anamnestic and statistical methods for collecting and analyzing data. Results. Patients of both groups were comparable in terms of the disease duration, the frequency of family cases occurrence, and gender. While changes in cognitive functions are heterogeneous in different groups, ET-P patients show changes in visual-spatial functions, speech and short-term memory, which forms an amnestic type of intellectual impairment. The heterogeneity of the clinic of ET-P patients may indicate the involvement of various brain structures, in addition to the cerebellum, in the pathophysiological process.
Spontaneous hematomas in hospital patients with new coronavirus infection
Authors:   Republic Clinical Hospital, PLOTNIKOV M. V. , MAKSIMOV A. V. ,   Republic Clinical Hospital, TEREGULOV A. YU. ,   Republic Clinical Hospital, MULLAKHMETOV R. M. ,   Republic Clinical Hospital
Published: August 2023

Treatment of the new coronavirus infection (NCVI) is associated with high risks of hemorrhagic complications. This is due to the use of anticoagulants to prevent coagulopathy and thrombotic complications, which are the most frequent and severe complications of NCVI. The article presents the results of a retrospective analysis of 80 cases of spontaneous hematomas in patients with NCVI who were treated in a temporary infectious diseases hospital of the Republic of Clinical Hospital. Verification of the diagnosis was carried out using clinical data, ultrasound diagnostics, and computed tomography. The mean age of the patients was 62.4 ± 14.47 years. The most common localizations of spontaneous hematoma were: abdominal wall — 31.3%, retroperitoneal hematoma — 26.3%, chest hematoma — 16.3%, lower or upper limb — 8.8%, neck — 3.8%, combined hematomas — 5%. The number of small hematomas was 87.5%, large – 12.5%. The highest incidence of spontaneous hematomas (74%) and mortality (22%) was recorded in the group of patients receiving therapeutic doses of anticoagulants. X-ray endovascular diagnosis of the source of bleeding and its embolization was performed in 15 patients. The use of therapeutic doses in patients with NCVI is accompanied by a high risk of developing spontaneous hematomas and, as a result, increases the risk of death. X-ray endovascular embolization of spontaneous hematomas is an effective and safe method of treatment in patients with NCVI.
MRI morphometric analysis of patients with Chiari malformation type 1 without small posterior cranial fossa
Authors:   Republic Clinical Hospital, FAIZUTDINOVA А. Т. , BOGDANOV E. I. ,   Kazan State Medical University
Published: August 2023

Chiari malformation type 1 (СМ1) without a small posterior cranial fossa is a poorly studied variant of the «spectrum of classical primary СМ1», requiring careful differentiation with secondary forms of cerebellar ectopia. An MRI morphometric study was carried out in 59 patients with clinical symptoms of СМ1 (29 with syringomyelia) with ectopia of the cerebellar tonsils of 3 mm or more, a tight cisterna magna, the length of Clivus and Supraocciput of 40 mm or more. The comparison group consisted of 60 patients with classical СМ1 (30 with syringomyelia), and the control group consisted of 30 healthy subjects. As a result of the study, the features of bone phenotype of the pathology in question were revealed, and their pathogenetic role was discussed. The main features of the bone phenotype of clinically symptomatic CM1 without short bones and without signs of secondary cerebellar ectopia, along with the large size of the clivus, supraocciput and the volume of the posterior cranial fossa, are a decrease in the extra-bone part of the posterior cranial fossa, a sharpening of the angle of the bottom, or «funnel» of the posterior cranial fossa, narrowing of the anterior cerebrospinal spaces of the foramen magnum and a decrease in the anteroposterior diameter of the spinal canal at C2 and C6 levels.