bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychological anxiety, professional performance, and the impact of the COVID-19 pandemic: A study of healthcare providers at the University of Jordan Hospital
Authors: Alsmeheen Fadia Aied , Al Ghazawat Areen , Al Talahin Fatima
Published: August 2023

The profound ramifications of the COVID-19 pandemic have notably affected the health sector, posing a threat to the global healthcare system. Amid these challenges, this study examines the impact of the pandemic on the psychological and somatic domains of healthcare providers. Specifically, it evaluates the psychological anxiety levels and professional performance of healthcare providers at the University of Jordan Hospital, while investigating the correlation between anxiety and performance. The study, encompassing a sample of 211 individuals, introduces scales for measuring psychological anxiety and professional performance. Findings reveal a medium level of psychological anxiety and professional performance. A negative correlation emerges between anxiety and performance scores. Gender, age, and experience exhibit no statistically significant impact on anxiety or performance. The study underscores the need for experimental research in psychological health and life management, contributes a novel cognitive dimension to understanding psychological anxiety, and sheds light on factors shaping professional performance.
SPECTACULAR ISLAND TOURISM IN PULAU AMAN, PENANG MALAYSIA: THE VISITORS’ PERSPECTIVE
Authors: Abdul Latip Normah , Umar Mohd Umzarulazijo , Karim Rehmat , Yusoh Mohamad Pirdaus , Hua Ang Kean , Johnes Johan , Rashid Rahmah
Published: August 2023

Island tourism initiative plays a significant role in uplifting economic activity for the island and local people. The equilibrium point of view between service providers and visitors is essential. Therefore, visitors’ perspective is crucial in understanding the need and requirement for establishment in tourist spots, including islands. This study examines visitors' perception of the study area through 3 main elements: activity, social and physical, comfortable, and natural beauty. The research design uses a descriptive analysis approach that uses a 5-point Likert scale, namely strongly agree (SA), agree (A), not sure (NS), disagree (D) and strongly disagree (SD). As for research analysis, the study used the SPSS program and specifically focused on frequency, mean, mode, median and level of agreement as to expected output. Preliminary findings indicate that visitors strongly agree that the area has the potential to be developed as a top tourism spot with minor improvement facilities and eco-tourism products.
SUSTAINABLE URBAN PARK: A CASE STUDIES OF TAMAN AWAM TELUK LIKAS, KOTA KINABALU, SABAH. MALAYSIA
Authors: Abdul Latip Normah , Umar Mohd Umzarulazijo , Yusoh Mohamad Pirdaus , Mansur Kasim , Hua Ang Kean , Hussin Rosazman , Datu Nordin Dayang Siti Noorafidah
Published: August 2023

Urban Park is a manifest of healthy images surrounding the city and indicating policy the local authority implements. The studies purposely to measures the level of satisfaction in visitors toward the current condition of the study area as an urban recreational park. A descriptive research approach was used on 187 respondents in the study area. A Satisfaction Index Analysis (SIA) was imposed to see the level of visitor satisfaction with the environment, facilities and amenities provided. Preliminaries’ finding indicates that most respondents were satisfied with the facilities and amenities provided in the study area. Whereby for the SIA analysis from 29 variables, info signage with 0.9401 (excellence) is the highest, and oppositely the lowest is debris collection centre at 0.6086 (fair). The finding demonstrates that the local authority's facilities and amenities are sustained towards visitors to the area.
ISSUES, CHALLENGES AND STRATEGIES IN PROMOTING HIGH POTENTIAL TOURISM SPOTS AND PRODUCTS IN PERAK TENGAH
Authors: Mohamad Muhammad Rijal , Abdul Rahman Norainah , Abdullah Kamariah , Rahmat Arina , Ahmad Aizazi Lutfi , Isa Mohd Ismail , Omar Fatin Nabilah
Published: August 2023

The promotion of tourism sector is vital to ensure all existing and new potential areas can be explored successfully. This paper highlights the issues, and challenges in promoting the tourism sector in Perak Tengah. The promotional activities should be organized by all stakeholders which are inclusive of all relevant agencies and local operators. This study applied a qualitative approach through interviews conducted with all relevant agencies to examine the real issues of tourism sector and the development of future enhancements efforts in encouraging and stimulating the tourism sector in Perak Tengah.
Effect of surface morphology and interfaces on longitudinal phonon thermal conductivity in Ge(001) and Si/Ge(001) thin-film structures
Authors: Khamets A. L.  , Safronov I. V.  , Filonov A. B.  , Migas D. B.
Published: August 2023

In this work the method of non-equilibrium molecular dynamics was used to study the longitudinal phonon thermal transport at 300 K in nanoscale homogenous Ge(001) and layered Si/Ge(001) thin films with p(2x1) surface reconstruction along different directions. The appearance of thermal transport anysotropy in the films under consideration, which is due to both the surface morphology and sharp Si/Ge interfaces, has been established. For the direction when the dimers and Si-Ge bonds at the interface lie in a plane parallel to the direction of the heat flow, the lowest thermal conductivity is observed (~5-18 W/(m·K) in the range from ~1 to 27 nm). It is shown that for films with thicknesses of more than 13 nm for all directions, layered films have a lower thermal conductivity compared to homogenous ones. In this case, the role of the surface morphology and interfaces is reduced to different degrees of phonon localization and compensation for more heat-conducting Si layers, respectively. Keywords: thermal conductivity, molecular dynamics, Si/Ge thin-film, surface, interfaces.
A Digital Gaming Intervention to Strengthen the Social Networks of Older Dutch Adults: Mixed Methods Process Evaluation of a Digitally Conducted Randomized Controlled Trial
Authors: Janssen Jeroen , Châtel Bas , Den Heijer Nora , Tieben Rob , Deen Menno , Corten Rense , Peeters Geeske , Olde Rikkert Marcel
Published: August 2023

Background

Digital loneliness interventions for older adults are promising, yet conclusive evidence is lacking due to a lack of randomized controlled trials (RCTs) and difficulties with recruitment. Process evaluation of performed RCTs is essential to inform future interventions. Still, it is rarely carried out, resulting in an overly optimistic view of the impact of eHealth interventions on loneliness in older adults and options to conduct such research entirely remotely.

Objective

We describe a mixed methods process evaluation of a digitally conducted RCT assessing the effectiveness of a mobile social gaming app to facilitate meaningful social interactions in older adults.

Methods

We analyzed the questionnaire and game data of the RCT participants to evaluate recruitment and onboarding, intervention adherence, and intervention acceptability. The RCT participants were allocated either to the main group of older adults (aged 65 years or older) or the side group (aged between 18 and 64 years). The side group used networking to play with the older adults. We also conducted 6 post-RCT evaluation interviews and 1 focus group with a total of 4 RCT participants and 5 welfare organization representatives that aided in RCT recruitment.

Results

In total, 371 people aged 18 years or older signed up for the RCT, of which 64% (238/371) were aged 65 years or older. Of the total sample, 20% (76/371) installed the app and signed informed consent, showing a large dropout during onboarding. The high number of questions was a relevant barrier for participants. Both questionnaire and gameplay adherence were low. Participants indicated that the games elicited contact and a feeling of togetherness and proposed challenging and competitive games with increasing difficulty levels. They suggested focusing on enjoying the games rather than administering questionnaires.

Conclusions

Conducting a remote digital trial of a social gaming intervention for older adults is a great challenge. Remote recruitment and informed consent acquisition may often not result in sufficient participation. Personal engagement with fellow participants and researchers might be essential for adherence and enjoyment. Future digital gaming interventions should start with small-scale studies with in-person contact, repeated instructions, and fewer questionnaires.
Digital Transformation in the Diagnostics and Therapy of Cardiovascular Diseases: Comprehensive Literature Review (Preprint)
Authors: Stremmel Christopher , Breitschwerdt Rüdiger
Published: August 2023

BACKGROUND

The digital transformation of our health care system has experienced a clear shift in the last few years due to political, medical, and technical innovations and reorganization. In particular, the cardiovascular field has undergone a significant change, with new broad perspectives in terms of optimized treatment strategies for patients nowadays.

OBJECTIVE

After a short historical introduction, this comprehensive literature review aimed to provide a detailed overview of the scientific evidence regarding digitalization in the diagnostics and therapy of cardiovascular diseases (CVDs).

METHODS

We performed an extensive literature search of the PubMed database and included all related articles that were published as of March 2022. Of the 3021 studies identified, 1639 (54.25%) studies were selected for a structured analysis and presentation (original articles: n=1273, 77.67%; reviews or comments: n=366, 22.33%). In addition to studies on CVDs in general, 829 studies could be assigned to a specific CVD with a diagnostic and therapeutic approach. For data presentation, all 829 publications were grouped into 6 categories of CVDs.

RESULTS

Evidence-based innovations in the cardiovascular field cover a wide medical spectrum, starting from the diagnosis of congenital heart diseases or arrhythmias and overoptimized workflows in the emergency care setting of acute myocardial infarction to telemedical care for patients having chronic diseases such as heart failure, coronary artery disease, or hypertension. The use of smartphones and wearables as well as the integration of artificial intelligence provides important tools for location-independent medical care and the prevention of adverse events.

CONCLUSIONS

Digital transformation has opened up multiple new perspectives in the cardiovascular field, with rapidly expanding scientific evidence. Beyond important improvements in terms of patient care, these innovations are also capable of reducing costs for our health care system. In the next few years, digital transformation will continue to revolutionize the field of cardiovascular medicine and broaden our medical and scientific horizons.
Artificial Intelligence–Based Consumer Health Informatics Application: Scoping Review (Preprint)
Authors: Asan Onur , Choi Euiji , Wang Xiaomei
Published: August 2023

BACKGROUND

There is no doubt that the recent surge in artificial intelligence (AI) research will change the trajectory of next-generation health care, making it more approachable and accessible to patients. Therefore, it is critical to research patient perceptions and outcomes because this trend will allow patients to be the primary consumers of health technology and decision makers for their own health.

OBJECTIVE

This study aimed to review and analyze papers on AI-based consumer health informatics (CHI) for successful future patient-centered care.

METHODS

We searched for all peer-reviewed papers in PubMed published in English before July 2022. Research on an AI-based CHI tool or system that reports patient outcomes or perceptions was identified for the scoping review.

RESULTS

We identified 20 papers that met our inclusion criteria. The eligible studies were summarized and discussed with respect to the role of the AI-based CHI system, patient outcomes, and patient perceptions. The AI-based CHI systems identified included systems in mobile health (13/20, 65%), robotics (5/20, 25%), and telemedicine (2/20, 10%). All the systems aimed to provide patients with personalized health care. Patient outcomes and perceptions across various clinical disciplines were discussed, demonstrating the potential of an AI-based CHI system to benefit patients.

CONCLUSIONS

This scoping review showed the trend in AI-based CHI systems and their impact on patient outcomes as well as patients’ perceptions of these systems. Future studies should also explore how clinicians and health care professionals perceive these consumer-based systems and integrate them into the overall workflow.
Effect of a mobile health app on initiating antihypertensive medications in patients with untreated hypertension (Preprint)
Authors: Matsumura Koichiro , Nakagomi Atsushi , Yagi Eijiro , Yamada Nobuhiro , Funauchi Yohei , Kakehi Kazuyoshi , Yoshida Ayano , Kawamura Takayuki , Ueno Masafumi , Nakazawa Gaku , Tabuchi Takahiro
Published: August 2023

BACKGROUND

Few effective tools have been identified that facilitate the initiation of antihypertensive medications in patients with untreated hypertension.

OBJECTIVE

To determine whether a mobile health (mHealth) application facilitates the initiation of antihypertensive medications in patients with untreated hypertension.

METHODS

We analyzed a large, longitudinal, integrated database mainly comprising middle-aged, working people and their families. The database contained health checkup data, health insurance claims data, and mHealth app data. The mHealth app, kencom, is used to manage daily life logs (i.e. weight, number of steps) and to provide health information tailored to customers. Patients with untreated hypertension were defined using the baseline health checkup data. A multivariable logistic regression analysis was performed to examine the association between use of the mHealth app and the initiation of antihypertensive medications.

RESULTS

Among 50 803 eligible patients (mean age, 49 years; 78 % male) with a median follow-up period of 3.0 years. The rate of initiation of antihypertensive medication was 23.4 % vs. 18.5 % (p < 0.0001), which was significantly higher in the mHealth application group (n = 14 879) than in the non-user group (n = 35 924). Multivariable analysis revealed that usage of the mHealth app was associated with initiated antihypertensive medications (odds ratio 1.43, 95 % confidence interval 1.36–1.50).

CONCLUSIONS

In patients with untreated hypertension, the use of the mHealth app, which was not dedicated to hypertension treatment, was associated with the initiation of antihypertensive medications.

CLINICALTRIAL
Utilization of Sugar Palm (Arenga pinnata) Dreg in Biodegradable Plastic Processing
Authors: Pranoto Yudi , Hermawati Budi Ariyani , Supartono Wahyu , Pamungkas Agung Putra
Published: August 2023

Bioplastics are made from biomass sources that can be decomposed naturally in a relatively short time compared to plastics produced from synthetic polymers plastic. Sugar palm dregs are a promising source for bioplastics due to their abundance and renewability, and they do not compete with human needs. Sugar palm dregs contain enough crude fiber (41.66%) to produce strong bioplastics. Chitosan and glycerol are added to improve the performance of bioplastics. The responses observed included tensile strength, elongation at break, young modulus, thickness, biodegradability, and water vapor permeability. This study aims to determine the factors’ effect on the response parameters and find the optimal multiresponse combination to fabricate sugar palm dreg-based bioplastics. The experimental design was determined using Taguchi method, and multiresponse analysis was carried out using the Grey Relational Analysis approach. The results show that adding sugar palm dreg increased the tensile strength, Young modulus, and thickness of bioplastics but decreased the elongation at break. Adding chitosan affected the water vapor permeability, and glycerol increased the biodegradation percentage of bioplastics. The optimal combination of sugar palm dreg bioplastic was 3 grams of sugar palm dreg, 2 grams of chitosan, and 3 grams of glycerol. The combination resulted in a tensile strength of 1.46 MPa, 24.49 of elongation at break, 6.08 MPa of young modulus, 0.28 mm of thickness, 100% of biodegradation, and 0.61 g.mm/kPa.hour.m2. The results show that sugar palm dreg bioplastic is potential as future food packaging.
Microencapsulation of Sweet Potato Leaf (Ipomoea Batatas L.) Extract With Different Concentrations of Glucomannan Konjac and Maltodextrin Using Spray Drying Method
Authors: Sari Novi Indah Permata , Harmayani Eni , Santoso Umar
Published: August 2023

A large amount of phenolic compounds in sweet potato leaves are a potential source of antioxidants. However, polyphenol is sensitive under certain food processing, thereby needs innovation such as microencapsulation to maintain its stability. This study aimed to determine the encapsulation efficiency and characterization of microencapsulation of sweet potato leaf extract using maltodextrin (10% and 20%) combined with Konjac glucomannan (0.5%; 0.75% and 1%). The method used was spray drying using 120 oC inlet temperature. The result showed that the total phenolic compound of sweet potato leaves was 685.06 GAE mg/g extract. The antioxidant activity of sweet potato leaf extract with the DPPH method was 52.80% with an IC50 value of 26.73 ppm. The highest antioxidant activity of the microencapsulated powder sample (10% maltodextrin: 0.75% glucomannan) was 66.84% at a concentration of 100 ppm which had the greatest percent encapsulation efficiency (89.91%).The particle size distribution showed that encapsulated sweet potato leaf extract has a micro-size of around 0.296 µm (78.3%) with good homogeneity of the particle size which can be seen from the Pdi value of 0.304. Therefore, encapsulated sweet potato leaf with 0,75% glucomannan and 10% maltodextrin has the highest encapsulation efficiency and good characteristic.
Effect of Temperature Storage on Chemical Properties of Lokio Leaves (Allium chinense G Don)
Authors: Kumalasari Dianita , Supriyadi Supriyadi , Ningrum Andriati
Published: August 2023

Lokio (Allium chinense G Don) is widely used as seasoning in cooking because it contains amino acids that contribute to taste. Lokio is easily damaged during physical and chemical storage, affecting its quality. The study aims to determine the chemical changes of lokio leaves during storage. This study used a randomized design group with 3 temperature treatments, namely room temperature (30 ⁰C), air conditioning (20 ⁰C), and refrigerator (10 ⁰C). Weight loss was tested using a digital scale, color was tested using a chromameter, water content was tested using thermogravimetry, fat using Soxhlet, protein using Kjeldal, and ash using a muffle furnace. Reducing sugars were tested using the DNS method, amino acids using HPLC, and volatile compounds using GC MS Headspace. The data was analyzed using ANOVA then continued with Duncan test if the treatment has a significant difference (p < 0.05). In the room temperature treatment, the best treatment was obtained for 2 days of storage, AC storage for 4 days, and refrigerator temperature for 14 days of storage. Of all the best treatments for each storage temperature, the best treatment was obtained in the storage treatment using AC temperature (20 ⁰C) for 4 days. The treatment found that Lokio has a water content of 92.247%, fat of 2.47%, protein of 19.05%, ash of 14.20%, carbohydrates of 64.28%, and reducing sugar of 11.24 mg/ml. The major volatile compound content of the total storage is trimethyl sulfide and glutamic acid is the most amino acid in lokio leaves.
Ameliorative Synergistic Effect of Honey and MO on Lead-Induced Alteration of Biochemical and Haematological Indices in Clarias gariepinus
Authors: Ayandiran Tolulope , Akintola Adebola , Kehinde Busuyi David , Adijat Ogundola , Olatunde Fawole , Peter Akwu Bala , Akinniyi Akitunde , Kolade Folorunso
Published: August 2023

Lead confers deleterious damage to the cells and it is necessary to explore further and develop a more effective way to ameliorate lead toxicity. This study aims to investigate how honey and Moringa oleifera (MO) can synergistically provide a more effective way to ameliorate lead toxicity. Groups of ten fish (Clarias gariepinus) were given Pb (0.30 g) and supplemented feed (T1) containing both honey (5 g) and MO (5 g). Others received pb (0.30 g) and supplemented feed (T2) containing either honey (10 g) or (T3) containing MO (10 g). Finally, hematological and biochemical analysis were conducted and a decline in the hematological parameters was observed. Also, the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, creatinine, and malondialdehyde (MDA) significantly increased while glutathione (GSH) and superoxide dismutase (SOD) reduced in the group given lead only. However, these biochemical indices and hematological parameters are greatly restored in the group that received both honey and MO compared to the group that received either honey or MO. The findings of this study reveal that co-administration of both honey and MO synergistically damages caused by lead-induced toxicity better.
Leadership Style, Work Motivation, Work Stress, and Employee Performance: a Case Study of a Hospital
Authors: Hakim Adi Lukman , Faizah Erna Nur , Mas'adah Ninik , Widiatmoko Fajar Rizki
Published: August 2023

Introduction/Main Objectives: Employees are tools for achieving corporate objectives. Employees must be able to view, monitor, and comprehend the condition given the importance of leadership in the workplace. The management of human resources in medical industry is expected to enhance their job to achieve the goals, but the reality revealed their attempts fall far of what is requested for sustaining it. Background Problems: Using scientific means, the researchers attempted to answer the following research questions, namely: 1) Does leadership style have a significant impact on employee performance at the hospital industry? 2) Does work motivation have a significant impact on employee performance at the hospital industry? 3) Does job stress have a significant effect on employee performance at the hospital industry? Novelty: This research was conducted in contextual (implementation of leadership style, work motivation and work stress hospital industry). In addition, the results contribute to demonstrate how closely related the two lines of inquiry are. Research Methods: The survey consists of questionnaires, interviews, and observations of the target sample. Data were analyzed using descriptive analysis and multiple regression analysis. Finding/Results: Employee success is significantly impacted by a leader's approach in medical industry. Employee success benefits positively from work drive, and job stress has a substantial effect on employee success. Overall, at same time a leadership styles, motivation and occupational stress has a favorable and impact important influence work in a hospital of hospital industry. Conclusion: Whatever leadership style a leader chooses, they must be mindful of the behavior of their work and relationships. There are several limitations to this latest study. Future researchers may therefore apply different leadership styles to different situations.
Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy
Authors: Kang Yuqi , Xu Boyang , Shi Sufang , Zhou Xujie , Chen Pei , Liu Lijun , Li Yebei , Leng Yueqi , Lv Jicheng , Zhu Li , Zhang Hong
Published: August 2023

Background

IgA nephropathy is the most common primary GN worldwide, with dominant deposition of IgA and co-deposits of complement component 3 (C3). Phenotypes and progression of IgA nephropathy varies among different ethnic populations, while patients with IgA nephropathy from Asia showed more severe clinical phenotypes, active kidney lesions, and rapid progression. Our previous genome-wide association study identified complement factor H (CFH) variant rs6677604, tightly linked with the deletion of CFH-related protein 3 and CFH-related protein 1 genes (ΔCFHR3-1), as IgA nephropathy susceptible variant, and additionally revealed its effect on complement regulation in IgA nephropathy.

Methods

To further explore the effect of rs6677604 on IgA nephropathy progression, here we enrolled a Chinese IgA nephropathy cohort of 1781 patients with regular follow-up for analysis. The rs6677604 genotype was measured, and the genotype-phenotype correlation was analyzed using the t test, the chi-squared test, or the nonparametric test, and the association between rs6677604 genotype or mesangial C3 deposition and IgA nephropathy prognosis was analyzed using Kaplan–Meier analysis and Cox regression.

Results

We found that patients with rs6677604-GG genotype had a stronger intensity of mesangial C3 deposition than those with the rs6677604-AA/AG genotype. Patients with IgA nephropathy who had stronger intensity of C3 deposition manifested with more severe clinical and pathological manifestations, including lower eGFR and higher Oxford-M/S/T/C (mesangial hypercellularity, endocapillary cellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy, and crescent) scores. In the survival analysis, stronger intensity of mesangial C3 deposition, but not rs6677604-GG genotypes, was associated with poor long-term kidney outcome in IgA nephropathy.

Conclusions

We found that in Chinese patients with IgA nephropathy, variant rs6677604 was associated with mesangial C3 deposition, and mesangial C3 deposition, but not rs6677604, was associated with IgA nephropathy severity and progression.
RAPP Lab Outcomes
Authors: Johannes Kretz  , Ivar Grydeland  , Evelyn Buyken  , Carla Conti  , Stella Louise Goeke  , Theodore Parker  , Sybille Fraquelli
Published: August 2023

RAPP Lab was a three-year EU-funded research project supported by the ERASMUS+ programme "Strategic Partnerships". RAPP stands for "Reflection based Artistic Professional Practice". The project took forward through a series of multi-national encounters described as Labs.

RAPP Lab explored how the reflective methodologies of Artistic Research empower musicians to creatively respond to the economic-cultural environment with which they are confronted. The project brought together the Artistic Research expertise of seven partner institutions in six different European states:

Association Européenne des Conservatoires – AEC Bruxelles, Belgium
Conservatorio di Musica Santa Cecilia Rome, Italy
Eesti Muusika- ja Teatriakadeemia Tallinn, Estonia
Hochschule für Musik und Tanz Köln, Cologne, Germany (as Coordinator)
mdw – Universität für Musik und darstellende Kunst Wien, Vienna, Austria
Norges musikhøgskole, NMH Oslo, Norway
Orpheus Instituut Ghent, Belgium
Importance of pure chemicals in investigations of cross sensitivity. Cross
Authors: Agrup G , Fregert S , Ovrum P.
Published: August 2023

No abstract available
Alcohol dermatitis.
Authors: Fregert S , Groth O , Hjorth N , Magnusson B , Rorsman H Ovrum
Published: August 2023

No abstract available
Anticomplementary reactions and their relation to some auto-immune phenomena in
Authors: Lassus A , Förström L , Piha HJ , Kiistala U
Published: August 2023

No abstract available
Pyoderma gangrenosum with systemic L.E
Authors: K. Olson
Published: August 2023

No abstract available
Hypersensitivity to secondary alcohols
Authors: S Fregert , O Groth , B Gruvberger , B Magnusson , H Mobacken , H. Rorsman
Published: August 2023

No abstract available
Occurrence and distribution of neuropeptides in the human skin. An immunocytochemical and immunochemical study on normal skin and blister fluid from inflamed skin
Authors: Wallengren J , Ekman R  , Sundler F
Published: August 2023

The content and distribution of substance P (SP), somatostatin, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) in human skin were investigated. Radioimmunoassay was performed on pooled tissue samples from several regions (fingers, toes, axillas and thighs) and on tissue fluid from spontaneous blisters on inflamed skin. Immunocytochemical localization showed all peptides examined except somatostatin to be present in nerve fibers. Nerve fibers storing SP and CGRP, which were found to coexist, were mostly present as free nerve endings in the superficial part of dermis and in epidermis. SP/CGRP fibers were most abundant in fingers and toes. VIP fibers and NPY fibers were localized in the deeper parts of dermis around blood vessels and acini of sweat glands. Also fibers containing these neuropeptides were most common in fingertips and toes. VIP occurred in relatively high amounts also in skin from axilla whereas NPY in this region was below detection limit. Immunoreactive somatostatin was found in low concentrations in tissue extracts and was not present in amounts sufficient for reliable immunostaining. Fluid from spontaneous blisters on inflamed skin contained detectable amounts of all neuropeptides.
Histological and immunological features of primary Kaposi´s sarcoma: evaluation before and after chemotherapy
Authors: Brambilla L , Boneschi V  , Pigatto PD , Finzi AF  , Marinig C , Renoldi P , Fiorini GF.
Published: August 2023

Forty-one patients with primary Kaposi´s sarcoma (KS) have been evaluated clinically, histologically and immunologically at the time of diagnosis. There was no correlation between histological and immunological features. Moreover, the disease did not appear to be related to particular HLA phenotypes. The T4/T8 ratio was augmented. Leu 7+ cells were also significantly increased. The last 15 patients who received chemotherapy were recently reevaluated after treatment and an increase in B lymphocytes was observed. We also observed that spindle-shaped cells (SSC), which appear later in the histopathological course of the disease, disappear first during chemotherapy, concomitantly with the increase in B cells. We conclude that the course of the disease appears to be controlled by the host´s immune response, though there is no clear correlation between histological and immunological evolution. Several immunological features differentiating it from AIDS associated KS have been found.
An in vitro human skin model for assaying topical drugs against dermatophytic fungi
Authors: Kligman AM , McGinley KJ  , Foglia A
Published: August 2023

A shortened modification of Dittmar´s in vitro human skin assay reliably predicts the efficacy of topical antifungals against ringworm fungi. Cadaver skin was treated with the test agents for 4 or 24 h. After heat separation of the epidermis for one minute at 60 degrees C, the undersurface was point inoculated with a spore suspension of T. mentagrophytes. In untreated skin fluffy, 3 mm colonies develop after 4 to 5 days of incubation. Effective fungistats produce complete inhibition of growth. Commercial formulations of the imidazoles, tolnaftate and ciclopirox were highly effective. Haloprogin, undecylenate, and hydroxyquinoline in proprietary form were inactive. There was a high correspondence between in vitro and in vivo effectiveness. The method should be useful for screening new antifungals and for optimal selection of vehicles.
Substrate specific sulfatase activity from hair follicles in recessive X-linked ichthyosis
Authors: Dijkstra AC , Vermeesch-Markslag AM  , Vromans EW , Happle R  , Van de Kerkhof PC , Zwanenburg B , Vos F , Vermorken AJ.
Published: August 2023

Recessive X-linked ichthyosis (RXLI) has its biochemical basis in a defect of the enzyme steroid sulfatase. Since several studies have reported a simultaneous deficiency of arylsulfatase C and steroid sulfatase it has been hypothesized that both enzymes are identical. In human hair follicles, however, hydrolytic activity for 4-methylumbelliferone sulfate, the substrate for arylsulfatase C, is found, while dehydroepiandrosterone sulfate is not hydrolyzed at all. These findings suggested the possible existence of two different enzymes. In the present paper structure-activity studies and molecular energy calculations are used for the demonstration that the remaining sulfatase activity in hair follicles of RXLI patients can be explained on the basis of the assumption that the enzyme has not lost its total function but has become less efficient.
Neutrophil function in psoriasis: effects of retinoids
Authors: Coble BI , Dahlgren C  , Molin L , Stendahl O
Published: August 2023

The present investigation focused on the oxidative response of polymorphonuclear neutrophil leukocytes in psoriasis, in particular pustular psoriasis and how this response was affected by different retinoid compounds. In the active phase of pustular psoriasis, the neutrophil chemiluminescence response to the chemotactic peptide f-met-leu-phe and to phorbol myristate acetate was enhanced and correlated to the development of pustules, whereas cells from psoriasis vulgaris patients showed normal chemiluminescence response. Retinoids, particularly tretinoin (= retinoic acid) and isotretinoin caused a pronounced inhibition of the chemiluminescence response only in primed neutrophils in vivo and in vitro, whereas etretinate and the metabolite Ro 10-1670 was less inhibitory. Retinoic acid furthermore inhibited the Fc-mediated phagocytosis, but did not affect C3bi-mediated phagocytosis. These data suggest that the antiinflammatory effect of retinoids may operate by affecting neutrophil activation and function.
The heterogeneity of tumours associated with epidermodysplasia verruciformis
Authors: Sandbank M , Hodak E  , Rotem A , Ben-David E
Published: August 2023

A patient with epidermodysplasia verruciformis also had lesions of seborrheic keratosis, irritated seborrheic keratosis, and intraepidermal and invasive squamous cell carcinoma as well as infiltrating squamous cell carcinoma associated with eccrine poroma. Electron microscope studies revealed intranuclear virus particles. Immunoperoxidase studies using rabbit anti-bovine papilloma virus serum showed a positive reaction.
Isotretinoin treatment of rosacea
Authors: Turjanmaa K , Reunala T.
Published: August 2023

Twenty patients with severe rosacea were treated with isotretinoin for 3-6 months. Six patients initially received 1.0 mg/kg and 14 patients 0.5 mg/kg of isotretinoin. The response was good or excellent in all patients and the papulopustular lesions in particular cleared promptly. Patients receiving 1.0 mg/kg of isotretinoin experienced more side-effects and the dose had to be lowered in five of the six patients. Seventeen of the 20 patients had no relapses during a follow-up of one year showing that isotretinoin has a long-lasting favourable effect in rosacea.
Multicultural Competence as a Teacher’s Metacognition to Achieve a Positive School Climate
Authors: Dyankova Gergana , Nikolova Simona
Published: August 2023

Our modern times are marked by socio-economic and cultural processes whose effects are rapidly crossing national borders and creating a global community for which multiculturalism is no longer just a concept but a social reality. As a key tool for its harmonization, intercultural education is determined, which provides conditions for interaction between cultures and prepares multicultural individuals. There is a need for the teacher to acquire the appropriate intercultural readiness and competence to enable her to posit the climate in the classroom. At the same time, there is a lack of research on the psychological climate in culturally mixed classrooms, characteristic of most schools today. The aim of the study is to investigate the importance of teachers’ “intercultural readiness” factors for achieving a positive psychological climate in a multicultural educational environment. The research instrument synthesizes questionnaires on the classroom, on the organization of the educational environment and on the psychological climate and adapts them to the level of primary school education. The sample consisted of 95 teachers from Attica in Greece. The data were analyzed with the statistical package SPSS and one-way ANOVA was applied. The research assumption is confirmed that universities preparing pedagogical specialists are responsible for developing master’s degree programs in intercultural education or courses for additional professional qualification with a focus on the formation of intercultural competence as a teacher’s metacognition.
Implementasi Program Merdeka Belajar-Kampus Merdeka di SD Negeri 07 Balingka
Authors: Wulandari Ratna Rosima , Ananda Azwar , Piliang Hasrul , Indrawadi Junaidi
Published: August 2023

This article aims to describe the implementation of the Teaching Campus Program Batch 1 Merdeka Belajar – Kampus Merdeka (MBKM) at SD Negeri 07 Balingka. The type of research used in this research is descriptive qualitative. The determination of informants in this study used a purposive sampling technique using data collection techniques including observation, interviews and documentation studies. Test the validity of the data in this study using data triangulation techniques. The data obtained were analyzed using data analysis techniques including data collection, data reduction, data presentation and drawing conclusions. The results showed that in the implementation of the Kamous Mengajar program Batch 1 at SD Negeri 07 Balingka there were stages in implementing the teaching campus namely the coordination stage, the observation stage, the planning stage, the activity program implementation stage and the reporting stage. In implementation, there are program activities including academic application, administrative application, application of technology adaptation and non-academic application. he reporting stage employed assessment instruments such as self-assessment, field supervisor assessment, teacher assessment, and peer assessment. During implementation there are supporting factors, namely good and clear communication, coordination and socialization. Meanwhile, the obstacles starting from the coordination stage to the reporting stage were lecture schedules that collided with campus teaching and the MBKM system had errors. The limitation of this study is that it does not show the inhibiting factors from the school side.
Fenomena Perilaku Moral Siswa Selama Daring di SMA Negeri 2 Solok Selatan
Authors: Salsabillah Nadya , Moeis Isnarmi , Fatmariza Fatmariza , Indrawadi Junaidi
Published: August 2023

This article aims to elucidate the various forms of student moral behavior observed during online learning, as well as to identify the underlying factors influencing such behavior both in the context of online learning and during the transition back to traditional classroom settings. The study explores diverse manifestations of student moral conduct, encompassing levels of honesty, discipline, and politeness. Employing a qualitative research design with a descriptive approach, data was collected at SMA N 2 Solok Selatan using purposive sampling for informant selection. The data gathering techniques encompassed interviews, documentation studies, and post-observation analysis. To ensure data validity, triangulation of sources was performed, and data was subsequently analyzed through collection, reduction, presentation, and conclusion stages. Findings revealed instances of student dishonesty during online learning, including plagiarism in friend's assignments, copying answers from the internet, and deceptive behavior towards parents. Additionally, students exhibited reduced politeness in their communication with teachers. The research also highlighted influential factors contributing to student moral behavior, attributing challenges in adjusting to the online learning system to both parents and teachers. The impact of this adaptation was observed in students' moral conduct during the transition back to conventional learning, manifesting as difficulty in completing assignments and a lack of self-confidence in offline learning settings.
Statistical data on crankshaft deflections of marine diesel engine
Authors: Vyazankin Vitaliy Valer'evich , Mamontov Victor Andreevich
Published: August 2023

The results of the study of crankshafts that have received a deflection during operation are presented. The reasons for the appearance of the curvature of the longitudinal axis and the consequences to which this defect may lead are considered. According to the analysis of statistical data obtained from enterprises engaged in engine repair, an increase in defects of residual deformation of deflections was noted. The necessity of collecting and systematizing cases of curvature of the longitudinal axis above the permissible value is determined. The conditions for preparing shafts for defecation have been clarified. Attention is drawn to the need to take into account the results of previous measurements and the total operating time of the engine when laying the shaft approved for further operation. The object of the study is the crankshaft of the diesel engine 6 CHN 31.8/33, used in water transport as the main marine engine. Measurements of the radial runout of twenty shafts that received deflection were made. The dependence of the measurement error on the radius of the shaft neck is established. A histogram of the frequency distribution of deflections of the crankshaft frame necks depending on the repair size number is constructed and the dependence of the deflection frequency on the repair size number is illustrated. The maximum deflection of the crankshaft of 4.10 mm with an allowable deflection of 0.03 mm is fixed. The values of deflections of diesel shafts are analyzed, their dependence on the number of the repair size and the number of the frame neck on which the deflection occurred. The frequency and significant increase in the magnitude of the deflection arrow on the fourth frame neck were noted. The necessity of using the obtained statistical data on deflections for the scientific substantiation of the technology of correction of diesel krancshafts is determined.
Comparative analysis of mathematical descriptions and pulse-width modulation methods
Authors: Gus'kov Vladimir Olegovich , Lavin Andrey Viktorovich
Published: August 2023

The article considers the mathematical description and comparison of the most common methods of pulse-width modulation (PWM) for a three-phase voltage inverter, namely vector PWM, PWM with third harmonic premodulation and classical PWM. In contrast to the classical mathematical description of PWM, a description is presented that is close to the implementation of modulation using modern microcontroller technology. The classic representation of PWM is based on comparing two signals. In this representation, the modulation pulse occurs at the moment when the modulating function is greater in value than the reference signal. When implementing PWM by a microcontroller, the pulse is placed within the period symmetrically with respect to the middle of the interval, while the pulse width is determined by the average value of the voltage modulating function. With a different mathematical description of PWM, the pulse is located differently within the modulation interval. There are presented the results of modeling and compares the mathematical descriptions of PWM methods according to the criterion of minimum dispersion of the current flowing in the load. As a result of the comparison, it was revealed that the same, differently described PWM algorithm gives different results. A comparison of vector PWM with a modified vector PWM was made. The modification consists in applying a dynamic pulse shift algorithm in such a way as to obtain a minimum of current dispersion in the load. Comparison of PWM methods was carried out at different frequencies of the reference signal; a static RL circuit was used as a load when simulating a three-phase voltage inverter. The results obtained allow us to recommend a pulse shift algorithm for implementing PWM in voltage inverters operating at relatively low PWM frequencies. Minimization of the current dispersion makes it possible to obtain improved energy and vibration-noise characteristics of the electric drive.
Multi-Criteria Problems of Energy Consumption in Buildings Considering Technical and Economic Indices
Authors: Jumintono J. , Salim Mohammed Abdulkreem , Lin Ming-Hung , Alshalal Mohammed Hayder , Ali Muneam Hussein , Braiber Hassan Taher
Published: August 2023

This study focuses on economic modelling of the energy consumption in buildings considering controllable appliances scheduling in stand-alone electrical grids. The economic modelling is implemented via coordination of the energy generation of the renewable energies with controllable appliances by using demand shifting strategy (DSS). On the other side, uncertainty and stochastic modelling of the renewable energies are considered in the optimal coordination. Also, optimal coordination is modelled by multi-criteria problems of the technical and economic indices. Solving of the multi-criteria problem is done by fuzzy and augmented epsilon-constraint methods. To investigate the effectiveness of the proposed model, it is applied on a 25-node test system through defining two scenarios. The obtained results show that modelling the optimal coordination to supply the demand of the grid can increase the efficiency of the system.
Kein Wachstum ist auch keine Lösung: Eine Kritik an Degrowth- und Postwachstumsansätzen
Authors: Lindner Fabian
Published: August 2023

In the face of climate change and other ecological problems, the degrowth and post-growth approaches are gaining more and more supporters. However, these growth-critical approaches have many problems. While the critique of growth is justified in many areas, the contraction or stagnation of production is associated with negative social and political consequences, as it would most likely lead to massive distributional conflicts. Moreover, a shrinking or stagnating GDP could make the necessary decarbonisation of the economy more difficult, because the investment required for decarbonisation would be much harder to implement in such an economy than in a growing economy.
Zeit, die Details einer besseren Elementarschadenversicherung zu diskutieren
Authors: Groß Christian , Wagner Gert G.
Published: August 2023

Damage to residential buildings caused by natural disasters will increase as climate change progresses. However, in Germany not all buildings are insured against it. This article gives an overview on the current debate in Germany on how to improve the common state of insurance. We present new empirical evidence on the acceptance of natural disaster insurances and outline the key parameters that should be subject to regulation. This includes the types of natural disasters that should typically covered by such an insurance, the level of the deductible to be paid by the household, state support for paying off the deductible, ways to deal with risk clusters that single insurers might face, as well as the specification of a stop-loss threshold to cap the insurers’ financial risks.