bluuebunny/crossref_metadata_2025 huggingface dataset:
New Perspectives on the Effect of Dandelion, Its Food Products and Other Preparations on the Cardiovascular System and Its Diseases
Authors: Olas Beata
Published: March 2022

Cardiovascular diseases (CVDs) have been the leading cause of death for over 20 years. The main causative factors are believed to be high cholesterol, obesity, smoking, diabetes, and a lack of physical activity. One of the most commonly used treatments is a combination of anticoagulant and antithrombotic therapy; however, it often causes unwanted side effects. The European Society of Cardiology, therefore, recommends a prophylactic strategy, including a varied diet rich in fruits, vegetables, and medicinal plants; all of which are sources of natural compounds with antiplatelet, anticoagulant, or antioxidant activities, such as phenolic compounds. One such plant with multidirectional health-promoting effects and a rich source of secondary metabolites, including phenolic compounds, is dandelion (Taraxacum officinale). The present mini-review presents the current state of knowledge concerning the effects of dandelion consumption on the cardiovascular system and CVDs based on various in vitro and in vivo trials; it discusses the value of dandelion as a food product, as well as extracts and pure compounds, such as chicoric acid, which can be obtained from the various plant organs. The paper also sheds new light on the mechanisms involved in this activity and describes the cardioprotective potential of dandelion products and preparations.
Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study
Authors: Vasto Sonya , Di Gaudio Francesca , Raso Maria , Sabatino Leo , Caldarella Rosalia , De Pasquale Claudio , Di Rosa Luigi , Baldassano Sara
Published: March 2022

Diabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and among them molybdenum is an essential component. There are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis but recent studies in humans suggest that molybdenum could exert hypoglycemic effects. The present study aims to assess if consumption of lettuce biofortified with molybdenum influences glucose homeostasis and whether the effects would be due to changes in gastrointestinal hormone levels and specifically Peptide YY (PYY), Glucagon-Like Peptide 1 (GLP-1), Glucagon-Like Peptide 2 (GLP-2), and Gastric Inhibitory Polypeptide (GIP). A cohort of 24 people was supplemented with biofortified lettuce for 12 days. Blood and urine samples were obtained at baseline (T0) and after 12 days (T2) of supplementation. Blood was analyzed for glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity, PYY, GLP-1, GLP-2 and GIP. Urine samples were tested for molybdenum concentration. The results showed that consumption of lettuce biofortified with molybdenum for 12 days did not affect beta cell function but significantly reduced fasting glucose, insulin, insulin resistance and increased insulin sensitivity in healthy people. Consumption of biofortified lettuce did not show any modification in urine concentration of molybdenum among the groups. These data suggest that consumption of lettuce biofortified with molybdenum improves glucose homeostasis and PYY and GIP are involved in the action mechanism.
Anti-Inflammatory and Analgesic Effects of Schisandra chinensis Leaf Extracts and Monosodium Iodoacetate-Induced Osteoarthritis in Rats and Acetic Acid-Induced Writhing in Mice
Authors: Lee Yun Mi , Son Eunjung , Kim Seung-Hyung , Kim Dong-Seon
Published: March 2022

In this study, we aimed to determine the anti-inflammatory and antinociceptive activities of Schisandra chinensis leaf extracts (SCLE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, an acetic acid-induced mouse model of writhing, and a monosodium iodoacetate (MIA)-induced rat model of osteoarthritis (OA). In LPS-stimulated RAW264.7 cells, a 100 µg/mL dose of SCLE significantly reduced the production of nitric oxide (NO), interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and prostaglandin E2 (PGE2). Acetic acid-induced writhing responses in mice that quantitatively determine pain were significantly inhibited by SCLE treatment. In addition, SCLE significantly decreased the MIA-induced elevation in OA symptoms, the expression levels of pro-inflammatory mediators/cytokines and matrix metalloproteinases, and cartilage damage in the serum and joint tissues. Our data demonstrated that SCLE exerts anti-osteoarthritic effects by regulating inflammation and pain and can be a useful therapeutic candidate against OA.
Telenutrition: Changes in Professional Practice and in the Nutritional Assessments of Italian Dietitian Nutritionists in the COVID-19 Era
Authors: Gnagnarella Patrizia , Ferro Yvelise , Monge Taira , Troiano Ersilia , Montalcini Tiziana , Pujia Arturo , Mazza Elisa
Published: March 2022

The COVID-19 pandemic has brought about various restrictions around the world, and its impact on healthcare has been enormous: RDNs have had to shift from in-person interactions with clients to telenutrition consultations, encountering obstacles. We designed the first survey to investigate the changes in RDN practices related to telenutrition provision after the onset of the pandemic through an online survey in Italy. Four hundred and thirty-six responses were analyzed. Before the pandemic, only 16% of Italian RDNs provided telenutrition; this percentage increased significantly up to 63% (p < 0.001). Among patients, the lack of interest in accessing telenutrition (30.9%) and the Internet (16.7%) were the most frequently reported barriers. Among RDNs, one of the main obstacles was their inability to conduct nutritional evaluation or monitoring activities (24.4%). Our survey indicated that increased adoption of telenutrition can be a valid, safe alternative to face-to-face visits. Telenutrition was mainly used by young RDNs (20–39 years) with fewer years of professional experience (0–20 years) and master’s degrees. Remote nutrition can enable RDNs to maintain normal workloads and provide patients with uninterrupted access to nutritional healthcare. It is important that RDNs using telemedicine resources possess the ability to provide high-quality, efficient, and secure services using evidence-based guidance.
The Influence of Intracellular Glutathione Levels on the Induction of Nrf2-Mediated Gene Expression by α-Dicarbonyl Precursors of Advanced Glycation End Products
Authors: Zheng Liang , van Dongen Katja C. W. , Bakker Wouter , Miro Estruch Ignacio , Rietjens Ivonne M. C. M.
Published: March 2022

α-Dicarbonyl compounds, particularly methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), are highly reactive precursors for the formation of advanced glycation end products (AGEs). They are formed in vivo and during food processing. This study aimed to investigate the role of intracellular glutathione (GSH) levels in the induction of Nrf2-mediated gene expression by α-dicarbonyl compounds. The reactions between α-dicarbonyl compounds (MGO, GO, and 3-DG) and GSH were studied by LC-MS in a cell-free system. It was shown that these three α-dicarbonyl compounds react instantaneously with GSH, with the GSH-mediated scavenging decreasing in the order MGO > GO > 3DG. Furthermore, in a cell-based reporter gene assay MGO, GO, and 3-DG were able to induce Nrf2-mediated gene expression in a dose-dependent manner. Modulation of intracellular GSH levels showed that the cytotoxicity and induction of the Nrf2-mediated pathway by MGO, GO and 3-DG was significantly enhanced by depletion of GSH, while a decrease in Nrf2-activation by MGO and GO but not 3-DG was observed upon an increase of the cellular GSH levels. Our results reveal subtle differences in the role of GSH in protection against the three typical α-dicarbonyl compounds and in their induction of Nrf2-mediated gene expression, and point at a dual biological effect of the α-dicarbonyl compounds, being reactive toxic electrophiles and -as a consequence- able to induce Nrf2-mediated protective gene expression, with MGO being most reactive.
Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
Authors: Marie Solène , Hernández-Lozano Irene , Le Vée Marc , Breuil Louise , Saba Wadad , Goislard Maud , Goutal Sébastien , Truillet Charles , Langer Oliver , Fardel Olivier , Tournier Nicolas
Published: March 2022

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. 99mTc-mebrofenin imaging was performed in rats after the injection of lipopolysaccharide (LPS). Changes in transporter expression were assessed using quantitative polymerase chain reaction of resected liver samples. Moreover, the particular impact of pharmacokinetic drug–drug interactions in the context of endotoxemia was investigated using rifampicin (40 mg/kg), a potent inhibitor of hepatocyte transporters. LPS increased 99mTc-mebrofenin exposure in the liver (1.7 ± 0.4-fold). Kinetic modeling revealed that endotoxemia did not impact the blood-to-liver uptake of 99mTc-mebrofenin, which is mediated by organic anion-transporting polypeptide (Oatp) transporters. However, liver-to-bile and liver-to-blood efflux rates were dramatically decreased, leading to liver accumulation. The transcriptomic profile of hepatocyte transporters consistently showed a downregulation of multidrug resistance-associated proteins 2 and 3 (Mrp2 and Mrp3), which mediate the canalicular and sinusoidal efflux of 99mTc-mebrofenin in hepatocytes, respectively. Rifampicin effectively blocked both the Oatp-mediated influx and the Mrp2/3-related efflux of 99mTc-mebrofenin. The additive impact of endotoxemia and rifampicin led to a 3.0 ± 1.3-fold increase in blood exposure compared with healthy non-treated animals. 99mTc-mebrofenin imaging is useful to investigate disease-associated change in hepatocyte transporter function.
Targeting Viral Ion Channels: A Promising Strategy to Curb SARS-CoV-2
Authors: Singh Anamika , Arkin Isaiah T.
Published: March 2022

SARS-CoV-2 is the etiological agent COVID-19, one of the most impactful health crises afflicting humanity in recent decades. While research advances have yielded several treatment and prevention options, the pandemic is slow to abate, necessitating an expansion of our treatment arsenal. As a member of the coronaviridae, SARS-CoV-2 contains several ion channels, of which E and 3a are the best characterized. Since ion channels as a family are excellent drug targets, we sought to inhibit both viroporins as a means to curb infectivity. In a previous targeted study, we identified several blockers to each channel from an extensive drug repurposing library. Herein, we examined the ability of said compounds on the whole virus in cellulo. Gratifyingly, many of the blockers exhibited antiviral activity in a stringent assay examining protection from viral-driven death. In particular, darapladib and flumatinib, both 3a blockers, displayed potent antiviral activity. Furthermore, appreciable synergism between flumatinib and several E blockers was identified in a concentration regime in which the compounds are present in human plasma following oral administration. Taken together, targeting ion channels represents a promising approach to both augment and complement our antiviral arsenal against COVID-19.
Mechanisms, Pathophysiology and Current Immunomodulatory/Immunosuppressive Therapy of Non-Infectious and/or Immune-Mediated Choroiditis
Authors: Papasavvas Ioannis , Tugal-Tutkun Ilknur , Herbort Carl P.
Published: March 2022

Non-infectious choroiditis comprises immune-mediated diseases resulting from diverse pathophysiological mechanisms. These conditions are sub-divided into two main groups, (1) diseases of the choriocapillaris and (2) diseases of the choroidal stroma. The purpose of this study is to expose the pathophysiology of the most common diseases of both these groups and recommend the optimal immunomodulatory/immunosuppressive therapy of each analyzed condition based on literature data and data from our own centers. Material and Methods: Narrative review. In the group of choriocapillaritis entities or primary inflammatory choriocapillaropathies (PICCPs) including multiple evanescent white dot syndrome (MEWDS), acute posterior multifocal placoid pigment epitheliopathy (APMPPE), idiopathic multifocal choroiditis (MFC) and serpiginous choroiditis (SC), as well as secondary choriocapillaritides including acute syphilitic posterior multifocal placoid chorioretinitis (ASPMPC) and tuberculosis-related SC (TB-SC), were analyzed. In the group of stromal choroidites, HLA-A29 birdshot retinochoroiditis (BRC) and Vogt-Koyanagi-Harada (VKH) disease were included. For each entity a literature search, in the PubMed database, on treatment was performed and analyzed and the therapeutic attitudes of our own centers were presented. Management of immune-mediated choroiditis implies vigorous immunosuppressive therapy given in a prompt and prolonged fashion in most of these entities.
Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3-f]quinoline Derivatives
Authors: Chaudhary Chhabi Lal , Ko Seungyun , Lee Chaerim , Kim Yerin , Jung Chanhyun , Hyun Soonsil , Kwon Youngjoo , Kang Jong-Soon , Jung Jae-Kyung , Lee Heesoon
Published: March 2022

With the several targets of cancer treatment, inhibition of DNA topoisomerase activity is one of the well-known focuses in cancer chemotherapy. Here, we describe the design and synthesis of a novel series of pyrazolo[4,3-f]quinolines with potential anticancer/topoisomerase inhibition activity. Forty newly designed pyrazolo[4,3-f]quinoline derivatives were synthesized via inverse imino Diels–Alder reaction. The antiproliferative activity of the synthesized derivatives was initially measured in the human NUGC-3 cancer cell line. Then, the selected compounds 1B, 1C, 1M, 2A, 2D, 2E, 2F, and 2R with higher activity among tested compounds were screened against six cancer cell lines, including ACHN, HCT-15, MM231, NCI-H23, NUGC-3, and PC-3. The results demonstrated that the compounds 1M, 2E, and 2P were most effective in all cancer cell lines exhibiting GI50 below 8 µM. Among them, 2E showed an equivalent inhibition pattern of topoisomerase IIα activity to that of etoposide, positive control at a 100 µM dose.
Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model
Authors: Pavic Aleksandar , Stojanovic Zoran , Pekmezovic Marina , Veljović Đorđe , O’Connor Kevin , Malagurski Ivana , Nikodinovic-Runic Jasmina
Published: March 2022

Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we encapsulated Nys and AmB in medium chain length polyhydroxyalkanoates (mcl-PHA) microspheres (7–8 µm in diameter). The obtained formulations have been validated for antifungal activity in vitro against a panel of pathogenic fungi including species of Candida, Aspergillus, Microsporum and Trichophyton genera and toxicity and efficacy in vivo using the zebrafish model of disseminated candidiasis. While free polyenes, especially AmB, were highly toxic to zebrafish embryos at the effective (MIC) doses, after their loading into mcl-PHA microspheres, inner organ toxicity and teratogenicity associated with both drugs were not observed, even at 100 × MIC doses. The obtained mcl-PHA/polyene formulations have successfully eradicated C. albicans infection and showed an improved therapeutic profile in zebrafish by enhancing infected embryos survival. This approach is contributing to the antifungal arsenal as polyenes, although the first broad-spectrum antifungals on the market are still the gold standard for treatment of fungal infections.
Anti-Candida Properties of Gossypium hirsutum L.: Enhancement of Fungal Growth, Biofilm Production and Antifungal Resistance
Authors: de Lima Luciene Ferreira , Andrade-Pinheiro Jacqueline Cosmo , Freitas Maria Audilene , da Silva Adriely Idalina , Fonseca Victor Juno Alencar , da Silva Taís Gusmão , da Silva Josefa Carolaine Pereira , de Lima Rosilaine Honorato , Sales Débora Lima , Neves Rejane Pereira , de Brito Edy Sousa , Ribeiro Paulo Riceli Vasconcelos , Canuto Kirley Marques , Coutinho Henrique Douglas Melo , Siyadatpanah Abolghasem , Kim Bonglee , Morais-Braga Maria Flaviana Bezerra
Published: March 2022

(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC–QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC–QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts.
Design, Physicochemical Characterization, and In Vitro Permeation of Innovative Resatorvid Topical Formulations for Targeted Skin Drug Delivery
Authors: Ruiz Victor H. , Encinas-Basurto David , Sun Bo , Eedara Basanth Babu , Dickinson Sally E. , Wondrak Georg T. , Chow H. -H. Sherry , Curiel-Lewandrowski Clara , Mansour Heidi M.
Published: March 2022

Nonmelanoma skin cancers (NMSCs) are the most common malignancies worldwide and affect more than 5 million people in the United States every year. NMSC is directly linked to the excessive exposure of the skin to solar ultraviolet (UV) rays. The toll-like receptor 4 (TLR4) antagonist, resatorvid (TAK-242), is a novel prototype chemo preventive agent that suppresses the production of inflammation mediators induced by UV exposure. This study aimed to design and develop TAK-242 into topical formulations using FDA-approved excipients, including DermaBaseTM, PENcreamTM, polyethylene glycol (PEG)-400, propylene glycol (PG), carbomer gel, hyaluronic acid (HA) gel, and Pluronic® F-127 poloxamer triblock copolymer gel for the prevention of skin cancer. The physicochemical properties of raw TAK-242, which influence the compatibility and solubility in the selected base materials, were confirmed using X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), hot-stage microscopy (HSM), Raman spectroscopy, and attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopic analysis. The permeation behavior of TAK-242 from the prepared formulations was determined using Strat-M® transdermal diffusion membranes, and 3D cultured primary human-derived epidermal keratinocytes (EpiDermTM). Despite TAK-242′s high molecular weight and hydrophobicity, it can permeate through reconstructed human epidermis from all formulations. The findings, reported for the first time in this study, emphasize the capabilities of the topical application of TAK-242 via these multiple innovative topical drug delivery formulation platforms.
Advances on Solid-State Vortex Laser
Authors: Zhang Zhichao , Hai Lan , Fu Shiyao , Gao Chunqing
Published: March 2022

Vortex beams (VBs) are structured beams with helical wavefronts carrying orbital angular momentum (OAM) and they have been widely used in lots of domains, such as optical data-transmission, optical tweezer, quantum entanglement, and super-resolution imaging. The ability to generate vortex beams with favorable performance is of great significance for these advanced applications. Compared with extra-cavity schemes, such as spatial light modulation, mode conversion, and others which transform other modes into vortex modes, solid-state vortex lasers can output vortex beams directly and show advantages including a compact structure, high robustness, easy to integrate, and low cost. In this review, we summarize intra-cavity generation approaches to vortex beams in solid-state lasers. Our work on 1.6μm eye-safe vector vortex lasers is also introduced.
Mechanical Properties of Amide Functionalized CNT/NBR at Different Temperatures: A Molecular Dynamics Study
Authors: Ji Longcheng , Chen Lijia , Lin Li , Wang Shijie
Published: March 2022

A comprehensive study on the mechanical properties of a pure carbon nanotube (PCNT)/nitrile butadiene rubber (NBR) composite and an amide-functionalized carbon nanotube (CONH2–CNT)/nitrile butadiene rubber (NBR) composite was carried out using molecular dynamics (MDs) simulations at different temperatures. The effects of temperature on the mechanical properties, fractional free volume (FFV), MSD, dipole autocorrelation function, number of hydrogen bonds of PCNT composites, and functionalized CNT composites were analyzed and compared, and the pull-out behavior of the composites under different condition temperatures was simulated. The enhancement mechanism of the interface interaction between the functionalized carbon nanotubes and the NBR matrix was explained from an atomic point of view. The results show that, due to the existence of hydrogen bonds, higher interfacial binding energies were formed between PCNT and NBR, and FFVs and MSDs were restricted at each temperature, with the mechanical properties of the composites being improved by 5.02–25.93%.
Desiccation Cracking Behavior of Sustainable and Environmentally Friendly Reinforced Cohesive Soils
Authors: Izzo Michael Z. , Miletić Marta
Published: March 2022

Desiccation cracking of cohesive soils is the development of cracks on the soil surface as a result of a reduction in water content. The formation of desiccation cracks on the cohesive soil surface has an undesirable impact on the mechanical, hydrological, and physicochemical soil properties. Therefore, the main aim of this study is to experimentally and numerically investigate eco-friendly soil improvement additives and their effect on the desiccation cracking behavior of soils. Improvement of soil crack resistance was experimentally studied by conducting desiccation cracking tests on kaolin clay. Biopolymer xanthan gum and recycled carpet fibers were studied as potential sustainable soil improvement additives. In addition, image processing was conducted to describe the effect of an additive on the geometrical characteristics of crack patterns. The results show that the soil improvement additives generally enhanced the soil strength and reduced cracking. Furthermore, a hydro-mechanical model was developed to predict the moisture transfer and onset of desiccation cracks in plain and amended kaolin clays. Data obtained show that the inception of the desiccation cracking and radial displacements were delayed in the improved soil specimens, which is in agreement with the experimental data.
Physical, Mechanical and Perforation Resistance of Natural-Synthetic Fiber Interply Laminate Hybrid Composites
Authors: Mohd Bakhori Siti Nadia , Hassan Mohamad Zaki , Mohd Bakhori Noremylia , Jamaludin Khairur Rijal , Ramlie Faizir , Md Daud Mohd Yusof , Abdul Aziz Sa’ardin
Published: March 2022

Natural and synthetic fibres have emerged in high demand due to their excellent properties. Natural fibres have good mechanical properties and are less expensive, making them a viable substitute for synthetic fibers. Owing to certain drawbacks such as their inconsistent quality and hydrophilic nature, researchers focused on incorporating these two fibres as an alternative to improve the limitations of the single fibre. This review focused on the interply hybridisation of natural and synthetic fibres into composites. Natural fibres and their classifications are discussed. The physical and mechanical properties of these hybrid composites have also been included. A full discussion of the mechanical properties of natural/synthetic fibre hybrid composites such as tensile, flexural, impact, and perforation resistance, as well as their failure modes, is highlighted. Furthermore, the applications and future directions of hybrid composites have been described in details.
A Heating-Assisted Direct Ink Writing Method for Preparation of PDMS Cellular Structure with High Manufacturing Fidelity
Authors: Xu Kang , Li Dongya , Shang Erwei , Liu Yu
Published: March 2022

In response to the fact that most of the current research on silicone 3D printing suffers from structure collapse and dimensional mismatch, this paper proposes a heating-assisted direct writing printing method for commercial silicone rubber materials for preparing silicone foam with enhanced fidelity. In the experimental processes, the effects of substrate temperature, printing pressure, and printing speed on the filament width were investigated using a controlled variable method. The results showed the following: (1) the diameter of silicone rubber filaments was positively correlated with the printing pressure and substrate temperature, but negatively correlated with the printing speed; (2) the filament collapse of the large filament spaced foams was significantly improved by the addition of the thermal field, which, in turn, improved the mechanical properties and manufacturing stability of the silicon foams. The heating-assisted direct writing process in this paper can facilitate the development of the field of microelectronics and the direct printing of biomaterials.
Effects of Thermal Aging on Molar Mass of Ultra-High Molar Mass Polyethylene Fibers
Authors: Tsinas Zois , Orski Sara V. , Bentley Viviana R. C. , Gonzalez Lopez Lorelis , Al-Sheikhly Mohamad , Forster Amanda L.
Published: March 2022

Ultra-high molar mass polyethylene (UHMMPE) is commonly used for ballistic-resistant body armor applications due to the superior strength of the fibers fabricated from this material combined with its low density. However, polymeric materials are susceptible to thermally induced degradation during storage and use, which can reduce the high strength of these fibers, and, thus, negatively impact their ballistic resistance. The objective of this work is to advance the field of lightweight and soft UHMMPE inserts used in various types of ballistic resistant-body armor via elucidating the mechanisms of chemical degradation and evaluating this chemical degradation, as well as the corresponding physical changes, of the UHMMPE fibers upon thermal aging. This is the first comprehensive study on thermally aged UHMMPE fibers that measures their decrease in the average molar mass via high-temperature size exclusion chromatography (HT-SEC) analysis. The decrease in the molar mass was further supported by the presence of carbon-centered free radicals in the polyethylene that was detected using electron paramagnetic resonance (EPR) spectroscopy. These carbon-centered radicals result from a cascade of thermo-oxidative reactions that ultimately induce C–C ruptures along the backbone of the polymer. Changes in the crystalline morphology of the UHMMPE fibers were also observed through wide-angle X-ray diffraction (WAXS), showing an increase in the amorphous regions, which promotes oxygen diffusion into the material, specifically through these areas. This increase in the amorphous fraction of the highly oriented polyethylene fibers has a synergistic effect with the thermo-oxidative degradation processes and contributes significantly to the decrease in their molar mass.
Use of ImageJ Software for Assessment of Mechanical Damage to Starch Granules
Authors: Boruczkowski Tomasz , Boruczkowska Hanna , Drożdż Wioletta , Miszczak Marta , Leszczyński Wacław
Published: March 2022

This study attempted to assess the influence of mechanical forces on potato, tapioca, wheat, rice, and maize starch granules. For this purpose, we used digital analysis of microscopic images of starch granules before and after starch grinding using ImageJ software. Additionally, we studied the influence of temperature on the size and shape of starch granules by drying the starches for 30 min at 60 °C. Our results indicate that mechanical forces very rarely cause damage to starch granules, such as breaking or cracking. In most cases, the action of mechanical forces results only in smoother shape of starch granules and their shrinking, linked with rising temperature. Results of this study show that ImageJ software can be successfully used to assess starch granule size and shape.
Detailed Characterization of a Fully Additive Covalent Bonded PCB Manufacturing Process (SBU-CBM Method)
Authors: Acharya Sarthak , Sattar Shahid , Chouhan Shailesh Singh , Delsing Jerker
Published: March 2022

To bridge the technology gap between IC-level and board-level fabrications, a fully additive selective metallization has already been demonstrated in the literature. In this article, the surface characterization of each step involved in the fabrication process is outlined with bulk metallization of the surface. This production technique has used polyurethane as epoxy resin and proprietary grafting chemistry to functionalize the surface with covalent bonds on an FR-4 base substrate. The surface was then metalized using an electroless copper (Cu) bath. This sequential growth of layers on top of each other using an actinic laser beam and palladium (Pd) ions to deposit Cu is analyzed. State-of-the-art material characterization techniques were employed to investigate process mechanism at the interfaces. Density functional theory calculations were performed to validate the experimental evidence of covalent bonding of the layers. This manufacturing approach is capable of adding metallic layers in a selective manner to the printed circuit boards at considerably lower temperatures. A complete analysis of the process using bulk deposition of the materials is illustrated in this work.
Assessment of Natural Zeolite Clinoptilolite for Remediation of Mercury-Contaminated Environment
Authors: Nuić Ivona , Gosar Mateja , Ugrina Marin , Trgo Marina
Published: March 2022

The soil at ancient roasting sites in the surroundings of the Idrija mine (Slovenia) is highly contaminated with mercury. To assess the impact of mercury on groundwater by infiltration and find an eco-friendly remediation method, the leaching of mercury from the soil containing 1347 mg Hg/kg, followed by sorption of the total leached mercury on cost-effective natural zeolite (NZ) clinoptilolite, was performed. The leaching of soil in ultrapure water of pHo = 3.00–11.46 after 24 h resulted in the total leached mercury concentration in the range 0.33–17.43 µg/L. Much higher concentrations (136.9–488.0 µg/L) were determined after the first few hours of leaching and were high above the maximum permissible level in water for human consumption. The NZ showed very good sorption of the total leached mercury, with a maximum removal efficiency of 94.2%. The leaching of mercury in presence of the NZ resulted in a significant decrease of the total leached mercury (1.9–20.3 µg/L compared to 12.8–42.2 µg/L), with removal efficiencies up to 90.5%, indicating immobilization of mercury species. The NZ has a great potential for economically viable remediation of mercury-contaminated environment. However, efforts should be made in the further study of mercury leachability to reduce the mercury concentration in water to acceptable levels.
Study of Variational Inference for Flexible Distributed Probabilistic Robotics
Authors: Damgaard Malte Rørmose , Pedersen Rasmus , Bak Thomas
Published: March 2022

By combining stochastic variational inference with message passing algorithms, we show how to solve the highly complex problem of navigation and avoidance in distributed multi-robot systems in a computationally tractable manner, allowing online implementation. Subsequently, the proposed variational method lends itself to more flexible solutions than prior methodologies. Furthermore, the derived method is verified both through simulations with multiple mobile robots and a real world experiment with two mobile robots. In both cases, the robots share the operating space and need to cross each other’s paths multiple times without colliding.
The Optimal Phenological Phase of Maize for Yield Prediction with High-Frequency UAV Remote Sensing
Authors: Yang Bin , Zhu Wanxue , Rezaei Ehsan Eyshi , Li Jing , Sun Zhigang , Zhang Junqiang
Published: March 2022

Unmanned aerial vehicle (UAV)-based multispectral remote sensing effectively monitors agro-ecosystem functioning and predicts crop yield. However, the timing of the remote sensing field campaigns can profoundly impact the accuracy of yield predictions. Little is known on the effects of phenological phases on skills of high-frequency sensing observations used to predict maize yield. It is also unclear how much improvement can be gained using multi-temporal compared to mono-temporal data. We used a systematic scheme to address those gaps employing UAV multispectral observations at nine development stages of maize (from second-leaf to maturity). Next, the spectral and texture indices calculated from the mono-temporal and multi-temporal UAV images were fed into the Random Forest model for yield prediction. Our results indicated that multi-temporal UAV data could remarkably enhance the yield prediction accuracy compared with mono-temporal UAV data (R2 increased by 8.1% and RMSE decreased by 27.4%). For single temporal UAV observation, the fourteenth-leaf stage was the earliest suitable time and the milking stage was the optimal observing time to estimate grain yield. For multi-temporal UAV data, the combination of tasseling, silking, milking, and dough stages exhibited the highest yield prediction accuracy (R2 = 0.93, RMSE = 0.77 t·ha−1). Furthermore, we found that the Normalized Difference Red Edge Index (NDRE), Green Normalized Difference Vegetation Index (GNDVI), and dissimilarity of the near-infrared image at milking stage were the most promising feature variables for maize yield prediction.
A Two-Branch Convolutional Neural Network Based on Multi-Spectral Entropy Rate Superpixel Segmentation for Hyperspectral Image Classification
Authors: Mu Caihong , Dong Zhidong , Liu Yi
Published: March 2022

Convolutional neural networks (CNNs) can extract advanced features of joint spectral–spatial information, which are useful for hyperspectral image (HSI) classification. However, the patch-based neighborhoods of samples with fixed sizes are usually used as the input of the CNNs, which cannot dig out the homogeneousness between the pixels within and outside of the patch. In addition, the spatial features are quite different in different spectral bands, which are not fully utilized by the existing methods. In this paper, a two-branch convolutional neural network based on multi-spectral entropy rate superpixel segmentation (TBN-MERS) is designed for HSI classification. Firstly, entropy rate superpixel (ERS) segmentation is performed on the image of each spectral band in an HSI, respectively. The segmented images obtained are stacked band by band, called multi-spectral entropy rate superpixel segmentation image (MERSI), and then preprocessed to serve as the input of one branch in TBN-MERS. The preprocessed HSI is used as the input of the other branch in TBN-MERS. TBN-MERS extracts features from both the HSI and the MERSI and then utilizes the fused spectral–spatial features for the classification of HSIs. TBN-MERS makes full use of the joint spectral–spatial information of HSIs at the scale of superpixels and the scale of neighborhood. Therefore, it achieves excellent performance in the classification of HSIs. Experimental results on four datasets demonstrate that the proposed TBN-MERS can effectively extract features from HSIs and significantly outperforms some state-of-the-art methods with a few training samples.
Influence of Topographic Shading on the Mass Balance of the High Mountain Asia Glaciers
Authors: Wang Rongjun , Ding Yongjian , Shangguan Donghui , Guo Wanqin , Zhao Qiudong , Li Yaojun , Song Miao
Published: March 2022

Most studies attribute the glacier mass balance within High Mountain Asia (HMA) to climate change, ignoring the influence of its complex terrain. Knowledge of the influence of this complex terrain is crucial for understanding the spatial variability in its mass balance. However, there is a lack of any systematic assessment of this influence across HMA. Therefore, in this study, we used the glacier outlines and raster data (SRTM DEM, slope and aspect) to calculate the topographic shading of all 97,965 glaciers within HMA during the ablation period, which is regarded as a major index of the influence of complex terrain on the mass balance. The results showed that 27.19% of HMA glacier area was subjected to topographic shading, and regional differences were significant with respect to both their altitudinal and spatial distributions. The topographic shading contributed to the protection of the smallest glaciers from solar illumination. Furthermore, we found a significant correlation between the topographic shading and mass balance in these small north-facing glaciers. However, these small glaciers were most prevalent in the north-facing orientation, especially in West Kunlun, East Kunlun, Inner Tibet Plateau and Qilian Shan, where shading was found to increase with decreases in the glacier area. This indicates that complex terrain can affect the spatial distribution of the mass balance by altering the solar illumination pattern.
Characterization and Removal of RFI Artifacts in Radar Data via Model-Constrained Deep Learning Approach
Authors: Tao Mingliang , Li Jieshuang , Su Jia , Wang Ling
Published: March 2022

Microwave remote sensing instruments such as synthetic aperture radar (SAR) play an important role in scientific research applications, while they suffer great measurement distortion with the presence of radio frequency interference (RFI). Existing methods either adopt model−based optimization or follow a data−driven black−box learning scheme, and both have specific limitations in terms of efficiency, accuracy, and interpretability. In this paper, we propose a hybrid model−constrained deep learning approach for RFI extraction and mitigation by fusing the classical model-based and advanced data-driven method. Considering the temporal-spatial correlation of target response, as well as the random sparsity property for time−varying interference, a joint low−rank and sparse optimization framework is established. Instead of applying the iterative optimization process with uncertain convergency, the proposed scheme approximates the iterative process with a stacked recurrent neural network. By adopting this hybrid model−constrained deep learning strategy, the original unsupervised decomposition problem is converted to a supervised learning problem. Experimental results show the validity of the proposed method under diverse RFI scenarios, which could avoid the manual tuning of model hyperparameters as well as speed up the efficiency.
A New Method for Quantitative Analysis of Driving Factors for Vegetation Coverage Change in Mining Areas: GWDF-ANN
Authors: Li Jun , Qin Tingting , Zhang Chengye , Zheng Huiyu , Guo Junting , Xie Huizhen , Zhang Caiyue , Zhang Yicong
Published: March 2022

Mining has caused considerable damage to vegetation coverage, especially in grasslands. It is of great significance to investigate the specific contributions of various factors to vegetation cover change. In this study, fractional vegetation coverage (FVC) is used as a proxy indicator for vegetation coverage. We constructed 50 sets of geographically weighted artificial neural network models for FVC and its driving factors in the Shengli Coalfield. Based on the idea of differentiation, we proposed the geographically weighted differential factors-artificial neural network (GWDF-ANN) to quantify the contributions of different driving factors on FVC changes in mining areas. The highlights of the study are as follows: (1) For the 50 models, the average RMSE was 0.052. The lowest RMSE was 0.007, and the highest was 0.112. For the MRE, the average value was 0.007, the lowest was 0.001, and the highest was 0.023. The GWDF-ANN model is suitable for quantifying FVC changes in mining areas. (2) Precipitation and temperature were the main driving factors for FVC change. The contributions were 32.45% for precipitation, 24.80% for temperature, 22.44% for mining, 14.44% for urban expansion, and 5.87% for topography. (3) Over time, the contributions of precipitation and temperature exhibited downward trends, while mining and urban expansion showed positive trajectories. For topography, its contribution remains generally unchanged. (4) As the distance from the mining area increases, the contribution of mining gradually decreases. At 200 m away, the contribution of mining was 26.69%; at 2000 m away, the value drops to 17.8%. (5) Mining has a cumulative effect on vegetation coverage both interannually and spatially. This study provides important support for understanding the mechanism of vegetation coverage change in mining areas.
Acoustic Emission Source Location Using Finite Element Generated Delta-T Mapping
Authors: Yang Han , Wang Bin , Grigg Stephen , Zhu Ling , Liu Dandan , Marks Ryan
Published: March 2022

One of the most significant benefits of Acoustic Emission (AE) testing over other Non-Destructive Evaluation (NDE) techniques lies in its damage location capability over a wide area. The delta-T mapping technique developed by researchers has been shown to enable AE source location to a high level of accuracy in complex structures. However, the time-consuming and laborious data training process of the delta-T mapping technique has prevented this technique from large-scale application on large complex structures. In order to solve this problem, a Finite Element (FE) method was applied to model training data for localization of experimental AE events on a complex plate. Firstly, the FE model was validated through demonstrating consistency between simulated data and the experimental data in the study of Hsu-Nielsen (H-N) sources on a simple plate. Then, the FE model with the same parameters was applied to a planar location problem on a complex plate. It has been demonstrated that FE generated delta-T mapping data can achieve a reasonable degree of source location accuracy with an average error of 3.88 mm whilst decreasing the time and effort required for manually collecting and processing the training data.
Caring for Worldviews in Early Childhood Education: Theoretical and Analytical Tool for Socially Sustainable Communities of Care
Authors: Raivio Magdalena , Skaremyr Ellinor , Kuusisto Arniika
Published: March 2022

Societies of today are becoming increasingly pluralistic. This applies also to the diversity of values and worldviews in Swedish early childhood education and care (ECEC). Still, in the increasingly secular contexts, societal hegemony often fails to include children’s home religions and worldviews in the actions and understandings aiming towards inclusiveness. We argue that it is of critical importance to also include the plurality of worldviews in the educational perception of “the whole child” in the care and education taking place in ECEC. The purpose of this article is to connect the discussions in the fields of intercultural and interreligious education, in particular those dealing with the diversity of religions and worldviews, to discussions on care and social sustainability in ECEC. The UN Agenda 2030 for Sustainable Development promotes inclusive and equitable education, and the Convention on the Rights of the Child states children’s right to freedom of religion and a concern for the spiritual, moral, and social development. Our previous findings have illustrated the importance of religions and worldviews in the intercultural work within early childhood education, both empirically and conceptually, and as part of the moral core of teaching. This article employs feminist and postcolonial ethics of care as a theoretical lens in elaborating on the three key notions: social sustainability, care, and worldviews. Several discursive challenges that ECEC teachers in Sweden face in their work, to enhance social sustainability by supporting the child’s well-being and sense of belonging in the ECEC, have been outlined. To conclude, we bring forth a theoretical and analytical tool for the understanding, researching, and planning of socially sustainable communities of care.
Interpolated Stand Properties of Urban Forest Parks Account for Posted Facial Expressions of Visitors
Authors: Yu Fei , Deng Jianfeng , Ding Xiaogang , Ma Hongyan
Published: March 2022

Posted facial expressions on social networks have been used as a gauge to assess the emotional perceptions of urban forest visitors. This approach may be limited by the randomness of visitor numbers and park locations, which may not be accounted for by the range of data in local tree inventories. Spatial interpolation can be used to predict stand characteristics and detect their relationship with posted facial expressions. Shaoguan was used as the study area where a tree inventory was used to extract data from 74 forest stands (each sized 30 m × 20 m), in which the range was increased by interpolating the stand characteristics of another 12 urban forest parks. Visitors smiled more in parks in regions with a high population or a large built-up area, where trees had strong trunks and dense canopies. People who displayed sad faces were more likely to visit parks located in regions of hilly mountains or farmlands, where soils had a greater total nitrogen concentration and organic matter. Our study illustrates a successful case in using data from a local tree inventory to predict stand characteristics of forest parks that attracted frequent visits.