bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of Learning from Country on teachers’ understandings of place and community: insights from the Culturally Nourishing Schooling project
Authors: Coombs David , Langdon Shanna , Jabir Zana , Burgess Cathie , Amazan Rose
Published: June 2024

In this paper, we present findings from the Culturally Nourishing Schooling (CNS) project data, collected during and after a series of experiential and immersive Learning from Country (LFC) activities with teachers working in New South Wales (NSW) schools in Australia. LFC is positioned as the critical first step in the CNS whole-school reform project, which seeks to improve Aboriginal and Torres Strait Islander students’ educational experiences and outcomes by developing teacher capacity to deliver culturally responsive curriculum and pedagogies. By centring Country and community, LFC, along with four other CNS strategies, encourages teachers to think, act and relate differently with respect to First Nations students, families, communities and the places and histories in which they are grounded. Drawing on Burgess et al.’s LFC framework, we found evidence of teachers: professing an ethical commitment to respecting and honouring local Aboriginal knowledges and knowledge holders; understanding the importance of connectedness and relational practices in their teaching; reflecting critically on their pre-existing ideas about Aboriginal students and communities and developing ‘place-consciousness’ or ‘Country consciousness’. We conclude that the LFC strategy is influencing the ways that teachers conceptualise and enact education in relation to Country and community, with the potential to deliver significant benefits to First Nations students, families and communities.
Salvia officinalis leaf extract-stabilized NiO NPs, ZnO NPs, and NiO@ZnO nanocomposite: Green hydrothermal synthesis, characterization and supercapacitor application
Authors: Zenkin Kübra , Durmuş Sefa , Emre Deniz , Bilici Ali , Yılmaz Selehattin
Published: June 2024

In this study, NiO nanoparticles (NiO NPs) and NiO@ZnO nanocomposite were synthesized for the first time using a Salvia officinalis (S. officinalis) extract-assisted hydrothermal process. The S. officinalis leaf extract served as a natural reducing and capping agent. The synthesized NiO NPs, ZnO NPs, and NiO@ZnO nanocomposite were thoroughly characterized using various techniques, including Fourier-transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–Vis), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), energy-dispersive spectrometry (EDS) mapping, vibrating sample magnetometer (VSM), and cyclic voltammetry (CV) analysis. The direct and indirect band gap energies of NiO NPs, ZnO NPs, and NiO@ZnO were found to be 3.00, 2.28, and 2.71 eV, and 2.63, 1.91, and 2.23 eV, respectively. The crystallite sizes were analyzed using PXRD spectra through Scherrer and Williamson–Hall (W–H) methods. TEM analysis revealed that the average particle sizes of NiO NPs, ZnO NPs, and NiO@ZnO were 16.0, 207.5, and 31.0 nm, respectively. The magnetic properties of all nanomaterials were assessed via the VSM technique. Specific capacitance (Cs) values, determined from CV voltammograms, were 196.8, 632.4, and 785 Fg-1 at a scan rate of 25 mVs-1 for NiO NPs, ZnO NPs, and NiO@ZnO, respectively. These findings suggest that the green-synthesized NiO@ZnO nanocomposite holds significant potential as a high-performance electrode material for supercapacitor applications.
Clinical and diagnostic characteristics of Hashimoto’s encephalopathy: a single-center, retrospective study
Authors: Lee Jung-Ju , Park Soo-Min , Park Kyung-Il , Kang Kyusik , Lee Woong Woo , Kim Byung Kun , Kim Yong Soo , Yoo Ilhan
Published: June 2024

Background and purpose

Diagnosing Hashimoto’s encephalopathy (HE) is challenging. In contrast to other types of autoimmune encephalitis, HE shows an excellent response to steroid treatment. We aimed to investigate the rates of antithyroid antibodies (ATAs) and probable HE in patients with unexplained mental dysfunction and compare the clinical characteristics between the good- and poor-outcome groups.

Methods

We retrospectively reviewed the medical records and electroencephalography (EEG) and neuroimaging findings of patients admitted to the Department of Neurology of our hospital from March 1, 2006, to February 28, 2023. Using our proposed diagnostic criteria for probable HE, we compared the clinical characteristics between the good- and poor-outcome groups. We also investigated the rates of ATA positivity and probable HE.

Results

In total, 198 patients exhibited altered mentation, rapidly progressive cognitive decline, or myoclonus. ATA tests were performed on 86 patients, and the detection rates of ATAs and probable HE were 29.1% and 25.6%, respectively. Of the 22 patients enrolled, the good- and poor-outcome groups comprised 19 and 3 patients, respectively. Clinical seizures occurred in seven patients. Nonconvulsive status epilepticus on EEG was observed in six patients, all of whom were intractable to antiepileptic drugs. Nineteen of 21 patients (90.5%) treated with immunosuppressants showed good outcomes.

Conclusions

HE is a rare clinical disorder, but not as rare as previously thought. When HE is suspected, steroids should be considered the first-line treatment. Early diagnosis and adequate treatment are critical to achieve good outcomes in HE.
Cadmium and lead impact on biological phosphorus removal: metal partition and adsorption evaluation in wastewater treatment processes
Authors: Quiroga-Flores R. , Alwmark C. , Hatti-Kaul R. , Önnby L. , Tykesson E.
Published: June 2024

Understanding the effect and partition of metals in wastewater treatment plants (WWTPs) can aid in designing processes to reduce metal emissions. This study focused on the effects of cadmium and lead, exposed alone (Cd or Pb) and in combination (Cd + Pb), on the enhanced biological phosphorus removal (EBPR) process at lab-scale. Parameters related to the metabolism of propionate, phosphorus (P), polyhydroxyalkanoates, extracellular polymeric substances (EPS) and enzyme activities were compared with those of a normal EBPR process. The effects induced by Cd included an incomplete uptake of propionate and poor P removal. Both Cd and Pb induced higher EPS production and altered the sludge settling properties; the effect of the former being more pronounced. Additionally, both Cd and Pb caused a lower content of phosphorus in the sludge but for different reasons. Cd affected the overall P removal by altering the P-uptake/release rates. Although Pb did not affect P removal, it formed P-containing complexes, likely resulting in less P available to the bacteria of the EBPR process. When present together, Cd and Pb exhibited synergistic effects. Regarding solubility, Cd remained soluble whereas Pb was mostly insoluble prior to starting the EBPR process. Consequently, Cd and Pb partitioned mainly to the effluent and sludge, respectively. To counteract this outcome, a treatment using adsorbents prior to the EBPR process was applied. However, as only soluble metals such as Cd can be effectively removed, only the effluent quality could be potentially improved. Stringent measures for metals such as Pb should be taken upstream WWTPs.
50 Years of Research on the Psychology of Sport Injury: A Consensus Statement
Authors: Tranaeus Ulrika , Gledhill Adam , Johnson Urban , Podlog Leslie , Wadey Ross , Wiese Bjornstal Diane , Ivarsson Andreas
Published: June 2024

Factors influencing sport injury risk, rehabilitation outcomes, and return to sport processes have been the focus in various research disciplines (sports medicine, psychology and sociology). One discipline, with over 50 years of scholarship, is the psychology of sport injury. Despite the research in this field, there is no evidence-based consensus to inform professional practice. The aim of this original and timely consensus statement is to summarise psychological sport injury research and provide consensus recommendations for sport practitioners seeking to implement psychological principles into clinical practice. A total of seven experts with extensive experience outlined the consensus objectives and identified three psychology of sport injury sub-domains: risk, rehabilitation and return to sport. The researchers, grouped in pairs, prepared initial drafts of assigned sub-domains. The group met in Stockholm, and the three texts were merged into a draft and revised in an iterative process. Stress responses are the strongest psychological risk factor for acute injuries. Intra- and interpersonal factors, as well as sociocultural factors, are demonstrated psychosocial risk factors for overuse injuries. Stress management and mindfulness interventions to prevent injuries have been successfully implemented. The rehabilitation process may influence athlete’s cognitive, emotional, and behavioural responses. Social support, mindfulness, acceptance-based practices, and cognitive-behavioural based intervention programs reduce negative reactions. Return to sport includes various stages and different trajectories. Returning athletes typically experience concerns regarding competence, autonomy, and relatedness. It is recommended that athletes focus on the physical, technical, and psychological demands of their sport as they progress to increasingly intense activities. Interdisciplinary collaboration (e.g., sports medicine and psychology) would be beneficial in enhancing clinical practice and improving athlete outcomes.
Constructing Built-In Electric Fields with Semiconductor Junctions and Schottky Junctions Based on Mo–MXene/Mo–Metal Sulfides for Electromagnetic Response
Authors: Zeng Xiaojun , Jiang Xiao , Ning Ya , Gao Yanfeng , Che Renchao
Published: June 2024

The exploration of novel multivariate heterostructures has emerged as a pivotal strategy for developing high-performance electromagnetic wave (EMW) absorption materials. However, the loss mechanism in traditional heterostructures is relatively simple, guided by empirical observations, and is not monotonous. In this work, we presented a novel semiconductor–semiconductor–metal heterostructure system, Mo–MXene/Mo–metal sulfides (metal = Sn, Fe, Mn, Co, Ni, Zn, and Cu), including semiconductor junctions and Mott–Schottky junctions. By skillfully combining these distinct functional components (Mo–MXene, MoS2, metal sulfides), we can engineer a multiple heterogeneous interface with superior absorption capabilities, broad effective absorption bandwidths, and ultrathin matching thickness. The successful establishment of semiconductor–semiconductor–metal heterostructures gives rise to a built-in electric field that intensifies electron transfer, as confirmed by density functional theory, which collaborates with multiple dielectric polarization mechanisms to substantially amplify EMW absorption. We detailed a successful synthesis of a series of Mo–MXene/Mo–metal sulfides featuring both semiconductor–semiconductor and semiconductor–metal interfaces. The achievements were most pronounced in Mo–MXene/Mo–Sn sulfide, which achieved remarkable reflection loss values of − 70.6 dB at a matching thickness of only 1.885 mm. Radar cross-section calculations indicate that these MXene/Mo–metal sulfides have tremendous potential in practical military stealth technology. This work marks a departure from conventional component design limitations and presents a novel pathway for the creation of advanced MXene-based composites with potent EMW absorption capabilities.
Misiurewicz polynomials and dynamical units, part II
Authors: Benedetto Robert L. , Goksel Vefa
Published: June 2024

Fix an integer $$d\ge 2$$

d
≥
2

. The parameters $$c_0\in \overline{\mathbb {Q}}$$

c
0

∈

Q
¯

for which the unicritical polynomial $$f_{d,c}(z)=z^d+c\in \mathbb {C}[z]$$

f

d
,
c

(
z
)

=

z
d

+
c
∈
C

[
z
]

has finite postcritical orbit, also known as Misiurewicz parameters, play a significant role in complex dynamics. Recent work of Buff, Epstein, and Koch proved the first known cases of a long-standing dynamical conjecture of Milnor using their arithmetic properties, about which relatively little is otherwise known. Continuing our work from a companion paper, we address further arithmetic properties of Misiurewicz parameters, especially the nature of the algebraic integers obtained by evaluating the polynomial defining one such parameter at a different Misiurewicz parameter. In the most challenging such combinations, we describe a connection between such algebraic integers and the multipliers of associated periodic points. As part of our considerations, we also introduce a new class of polynomials we call p-special, which may be of independent number theoretic interest.
Potentiality of Melatonin for Reinforcing Salinity Tolerance in Sorghum Seedlings via Boosting Photosynthetic Pigments, Ionic and Osmotic Homeostasis and Reducing the Carbonyl/Oxidative Stress Markers
Authors: Helal Nesma M. , Saudy Hani S. , Hamada Maha M. A. , El-Yazied Ahmed Abou , El-Gawad Hany G. Abd , Mukherjee Soumya , Al-Qahtani Salem Mesfir , Al-Harbi Nadi Awad , El-Sayed Salwa M. , Ibrahim Mohamed F. M.
Published: June 2024

Salinity stress has become a major threat to worldwide crop production. Exogenous melatonin (MT) has appeared as a promising treatment against salt stress in several plant species. However, MT effect on the tolerance of sorghum plants under different saline conditions (moderate and severe) remains ambiguous. This study was carried out to explore the impact of MT (0, 50, 100 and 200 µM) as a foliar application on sorghum seedlings grown under moderate and severe saline conditions using sodium chloride, NaCl (75 and 150 µM NaCl). Salinity treatments were applied as solution in sand medium in pots. The results demonstrated that rising salinity level negatively affected plant growth, photosynthetic pigments (chlorophylls and carotenoids), leaf water status and ionic homeostasis (sodium, potassium, and calcium ions). Applied-MT specifically at 100 or 200 µM enhanced the osmotic balance, cell membrane stabilizing and leaf relative water content. These effects were associated with an obvious restriction to the level of hydrogen peroxide, lipid peroxidation (malondialdehyde content) and methylglyoxal. Moreover, antioxidant activities of peroxidase, catalase, superoxide dismutase, and ascorbate peroxidase enzymes were modulated by MT treatments. Molecular docking modeling assessment illustrated top-ranked confirmations between MT and the target antioxidant enzymes. MT forms multiple hydrogen bonds with key amino acid residues for glycine (A: 162), tryptophan (A: 41), leucine (A: 165), tyrosine (A: 235) in the active site of ascorbate peroxidase. The alkyl interactions with leucine (A: 37), arginine (A: 38) and cysteine (A: 168) also contribute to its high affinity. Despite sorghum plant is commonly moderately tolerant to salinity stress, the results of this study confirmed its high sensitivity to a wide range of saline conditions at early growth stages. Melatonin spraying led to improvements in various morphological, physiological and biochemical mechanisms that harmonized together to confer stress resistance to salt-stressed sorghum seedlings.
Banana peels as a green bioadsorbent for removing metals ions from wastewater
Authors: Jahin Hossam S. , Khedr Alaa I. , Ghannam Hala E.
Published: June 2024

Bioadsorption using agricultural waste offers a promising approach for removing toxic metals from wastewater. This study explores the potential of chemically activated banana peels (BPs) as a green and cost-effective bioadsorbent for Cu(II) and Zn(II) removal. Fourier-transform infrared (FTIR) spectroscopy revealed the presence of functional groups like alcohols, phenols, and amino acids on activated BPs, potentially responsible for metal ion binding. Scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDS) confirmed the presence of cavities on the BPs surface and the existence of oxygen and potassium. The adsorption capacity of BPs was investigated under various conditions, including pH, contact time, sorbent dosage, metal concentration, and temperature. This study used Langmuir, Freundlich, Tempkin, and Dubinin–Radushkevich (D–R) isotherm models to describe the equilibrium results of Cu (II) and Zn (II) adsorption. The Langmuir isotherm model best described the adsorption process, suggesting monolayer coverage of metal ions on the BPs surface. Maximum adsorption capacities were 3.2 mg g−1 for Cu(II) and 2.8 mg g−1 for Zn(II), demonstrating the effectiveness of BPs in metal removal. Kinetic studies indicated pseudo-first-order (PFO) behavior for Cu(II) and pseudo-second-order (PSO) behavior for Zn(II) adsorption. Thermodynamic analysis revealed a spontaneous and exothermic process (negative Gibbes free energy (ΔG°) and enthalpy (ΔH°) with decreased randomness [negative entropy (ΔS°)] at the biosorption interface. Finally, the BPs sorbent was successfully applied to remove different metal ions from real wastewater samples collected from the El Wadi drain.
Associative Electron Detachment in Sprites
Authors: Malagón‐Romero A. , Luque A. , Shuman Nicholas S. , Miller Thomas M. , Ard Shaun G. , Viggiano Albert A.
Published: June 2024

The balance of processes affecting electron density drives the dynamics of upper‐atmospheric electrical events, such as sprites. We examine the detachment of electrons from negatively charged atomic oxygen (O−) via collisions with neutral molecular nitrogen (N2) leading to the formation of nitrous oxide (N2O). Past research posited that this process, even without significant vibrational excitation of N2, strongly impacts the dynamics of sprites. We introduce updated rate coefficients derived from recent experimental measurements which suggest a negligible influence of this reaction on sprite dynamics. Given that previous rates were incompatible with the observed decay of the light emissions from sprite glows, our findings support that glows actually result from electron depletion in sprite columns.
A Transmitted Subseasonal Mode of the Winter Surface Air Temperature in the Mid‐ and High‐Latitudes of the Eurasia and Contributions From the North Atlantic and Arctic Regions
Authors: Li Shiyue , Hu Haibo , Ren Xuejuan , Perrie William , Yang Xiu‐Qun , Yu Peilong , Mao Kefeng
Published: June 2024

A significant and striking seesaw pattern of winter surface air temperature (SAT) has emerged, featuring pronounced warming Arctic and cooling Eurasian (referred to as WACE). This study investigates the subseasonal SAT modes across the mid‐ and high‐latitudes of Eurasia and their possible mechanisms based on daily reanalysis data from 1979 to 2022. Our results reveal that Eurasian winter SAT exhibits two distinct subseasonal modes, characterized by a correlated southeastward propagation of temperature and geopotential height anomalies (GHAs) in the middle and lower troposphere. Notably, the subseasonal SAT anomalies with eight phases constrained by the hydrostatic equilibrium, originate from the GHAs in the Arctic stratosphere and then transfer to the East Asia. The sixth phase of the transmitted subseasonal SAT mode is proved to be the key transition phase from the WACE pattern to its counterpart. Further analysis indicates that the strength of the transmitted subseasonal SAT mode is controlled by the tripolar sea surface turbulent heat flux anomalies over the north Atlantic.
A Study on the Possible Brown Ocean Effect: Impacts of an Antecedent Tropical Cyclone on the Rapid Intensification of the 1999 Odisha Supercyclone
Authors: Vijay Deebak V. S. , Chandrasekar Anantharaman
Published: June 2024

Odhisa, a state of India, bore the disastrous consequences of two consequent Tropical Cyclones (TCs), TC 04B and TC 05B (Odisha 1999 supercyclone), which formed over the Bay of Bengal and experienced landfall in October 1999, with a time gap of fewer than two weeks, over the same region. It is suggested that the first TC, TC 04B, provided an “ocean‐like situation” over the coastal land region, thus delivering the appropriate land conditions that would facilitate the intensification of the following second tropical cyclone, TC 05B; a clear illustration of the “Brown Ocean effect.” Two Weather Research Forecasting (WRF) simulations were conducted, with the control and experimental runs differing solely in the following aspect: the initial cyclonic vortex corresponding to the first TC at the initial time was removed in the experimental run, whereas it was retained in the control run. Both simulations were analyzed to reveal the “Brown Ocean Effect” role. The experimental run result indicates that the minimum central sea level pressure of the second TC was 35 hPa higher than the second TC simulation in the control run. The heavy rainfall associated with TC 04B led to increased soil moisture conditions, providing the second TC (TC 05B) with the necessary conditions for its intensification by the “Brown Ocean Effect.” The results of this study appear to strongly suggest that the “Brown Ocean Effect” could provide one of the main reasons for the extraordinary intensities associated with the 1999 Odisha supercyclone.
Near‐Storm Environmental Relationships With Tropical Oceanic Convective Structure Observed During NASA CPEX and CPEX‐AW
Authors: Rodenkirch Benjamin D. , Rowe Angela K.
Published: June 2024

Deep tropical oceanic convection (TOC) is a prevailing component of the tropical atmosphere and plays a significant role in modulating global weather and climate. Despite its importance, prediction challenges remain, partly attributed to a lack of understanding of how TOC relates to its near‐storm environments. Prior studies suggest location‐dependent relationships between TOC structure and associated environments, necessitating targeted regional studies. The NASA 2017 Convective Processes Experiment (CPEX) and 2021 CPEX—Aerosols & Winds (CPEX‐AW) field campaigns collected high‐resolution measurements of convective storms and their environments in the Gulf of Mexico, Caribbean, and western Atlantic basins, providing a rare opportunity to investigate near‐storm environmental relationships with 3‐D TOC structure where in situ non‐tropical cyclone‐related deep TOC research is comparatively lacking. Collocated CPEX and CPEX‐AW airborne observations from the multi‐wavelength Airborne Precipitation Radar, Doppler Aerosol Wind Lidar, and dropsondes revealed large near‐storm environmental variability across TOC of similar convective type (i.e., isolated, organized) and within individual convective systems. However, trends still emerged amongst the large environmental variability. Horizontal TOC structure was most consistently linked to planetary boundary layer and mid‐tropospheric near‐storm environments, with organized TOC being associated with generally greater relative humidity (RH) and vertical speed shear than isolated TOC. TOC intensity was linked to upper tropospheric (i.e., above melting level) near‐storm environments, with isolated TOC intensity most consistently associated with upper tropospheric CAPE and organized TOC intensity associated with upper tropospheric RH. Mesoscale low‐level convergence was also linked to greater organized TOC intensity, motivating further research using these unique data sets.
Inorganic Nitrogen Gas‐Aerosol Partitioning in and Around Animal Feeding Operations in Northeastern Colorado in Late Summer 2021
Authors: Li En , Pierce Jeffrey R. , Juncosa Calahorrano Julieta F. , Sullivan Amy P. , Pollack Ilana B. , Roscioli Joseph R. , Caulton Dana R. , McCabe Megan E. , Jathar Shantanu H. , Fischer Emily V.
Published: June 2024

Ammonia (NH3) from animal feeding operations (AFOs) is an important source of reactive nitrogen in the US, but despite its ramifications for air quality and ecosystem health, its near‐source evolution remains understudied. To this end, Phase I of the Transport and Transformation of Ammonia (TRANS2Am) field campaign was conducted in the northeastern Colorado Front Range in summer 2021 and characterized atmospheric composition downwind of AFOs during 10 research flights. Airborne measurements of NH3, nitric acid (HNO3), and a suite of water‐soluble aerosol species collected onboard the University of Wyoming King Air research aircraft present an opportunity to investigate the sensitivity of particulate matter (PM) formation to AFO emissions. We couple the observations with thermodynamic modeling to predict the seasonality of ammonium nitrate (NH4NO3) formation. We find that during TRANS2Am northeastern Colorado is consistently in the NH3‐rich and HNO3‐limited NH4NO3 formation regime. Further investigation using the Extended Aerosol Inorganics Model reveals that summertime temperatures (mean: 23°C) of northeastern Colorado, especially near the surface, inhibit NH4NO3 formation despite high NH3 concentrations (max: ≤114 ppbv). Finally, we model spring/autumn and winter conditions to explore the seasonality of NH4NO3 formation and find that cooler temperatures could support substantially more NH4NO3 formation. Whereas NH4NO3 only exceeds 1 μg m−3 ∼10% of the time in summer, modeled NH4NO3 would exceed 1 μg m−3 61% (88%) of the time in spring/autumn (winter), with a 10°C (20°C) temperature decrease relative to the campaign.
Global Stratospheric Properties of Gravity Waves From 1 Year of Radio Occultations
Authors: Alexander P. , de la Torre A. , Schmidt T.
Published: June 2024

Gravity waves (GW) transport momentum flux (MF) and energy across the lower, middle and upper atmosphere. Global Navigation Satellite System (GNSS) radio occultation (RO) is one of the measuring techniques used onboard satellites to provide vertical temperature profiles with global and permanent coverage. These retrievals may be applied in the study of GW. Most of the analysis methods provide absolute GWMF but are missing its net direction. This happens because the procedures can deduce the orientation but not the propagation sign of GW and hence the full direction of MF. We apply here a method that allows the net calculation with four close in space and time RO soundings (quartets). We use about 10,000 daily retrievals from 1 March 2022 to 28 February 2023 to study the seasonal and latitudinal characteristics of net GWMF in the height interval from 20 to 35 km. About 600 quartets were found. The calculated zonal MF and drag exhibited negative minima at middle and high latitudes during winter in the Southern Hemisphere. This well‐known characteristic is usually mainly assigned to orographic sources. A similar intensity in zonal MF and drag is found during the same season at low latitudes. Meridional components are generally less significant. Besides finding the correct sign of the GWMF and the corresponding forcing on the mean flow, the quartets method also allows the determination of the horizontal and vertical wavelengths, the amplitude and sign of the vertical wave phase velocity and the intrinsic frequencies. The global statistics of these parameters are shown and each one exhibits a similar distribution shape across latitude bands. Large differences in the frequency of cases in vertical phase velocity sign appear only at low and high positive latitudes. The most even distribution of GW intrinsic frequency is found at low latitudes. We estimate that absolute MF calculations by methods assuming only upward GW propagation may produce a bias not larger than 40%. The increase of satellite measuring devices achieved in the last years due to the release of new missions led to a high spatial and temporal density of profiles that may allow the attainment of net GWMF climatologies over a seasonal time scale and about 4,000 km latitude bands but this performance may be even improved if the amount of retrievals continues to rise.
BaHys—A Bayesian Modeling Framework for Long‐Term Concentration‐Discharge Hysteresis: A Case Study on Chloride
Authors: Cairoli Maria , Souza Francisco , Stroomberg Gerard , Postma Geert , Buydens Lutgarde , Jansen Jeroen
Published: June 2024

Improving river water quality requires a thorough understanding of the relationship between constituent concentration and water discharge during runoff events (i.e., C‐Q hysteresis), which may be strongly non‐linear. Analysis of C‐Q hysteresis on large temporal scales provides unprecedented insights into event dynamics and long‐term concentration trends in surface and groundwater. Despite the increasing availability of time series data on water quality, there are still limited quantitative modeling frameworks that enable this analysis. Here, we combine Bayesian modeling and an existing mass balance to model long‐term C‐Q hysteresis dynamics in multi‐decade constituent concentration and water discharge time series. We focus on the case study of chloride and demonstrate that our model can simultaneously characterize the size and rotation of C‐Q hysteresis, and diffuse and low‐flow inputs to constituent concentration using only time‐series data from the river Rhine. Over 28 years of monitoring, we find that chloride exhibits a dominant clockwise dilution behavior that does not vary considerably under different hydro‐climatic conditions, hinting to similar mobilization mechanisms over time. We also show decreasing chloride concentrations in surface and groundwater, due to the cessation of mining activities in the Rhine. Our approach uses uncertainty estimates to show the range within which model parameter values lie, aiding decision‐makers in a robust assessment of river water quality. We conclude that Bayesian modeling of C‐Q hysteresis provides a powerful framework for investigating long‐term contamination dynamics that can be extended to several constituents to find factors controlling their export, ultimately suggesting mitigation measures for river contamination.
Impact of Depth‐Dependent Heterogeneity in Aquifers on the Response of Unsaturated‐Saturated Flow to Earth Tides
Authors: Wang Guoliang , Liang Xiuyu , Li Jiebiao , Wang Ju , Wang Chi‐Yuen
Published: June 2024

Heterogeneity is a natural characteristic of aquifers, which has a profound influence on groundwater flow and solute transport. However, the heterogeneity in an aquifer is difficult to characterize and its impact on groundwater response to Earth tides remains insufficiently explored. A common heterogeneity in thick aquifers is the decrease in porosity and hydraulic conductivity with depth. In the present study, we present an analytical model that includes this particular heterogeneity in both the unsaturated and saturated zones to explore its impact on the tidal response. Our results reveal that, as the hydraulic conductivity decays with depth, the amplitude ratio of the tidal response increases and its phase shift decreases, and the impact of the capillary zone on tidal responses is primarily restricted to the shallow region of the aquifer. Neglecting the decay of conductivity in the previous models would result in underestimation of the amplitude ratio and overestimation of the phase shift. The solutions are applied to the field data to effectively estimate the decay in conductivity with depth. This study highlights the importance of considering aquifer heterogeneity in the analysis of the response of saturated and unsaturated flow to Earth tides.
How the Ionosphere Responds Dynamically to Magnetospheric Forcing
Authors: Laundal K. M. , Hatch S. M. , Reistad J. P. , Ohma A. , Tenfjord P. , Madelaire M.
Published: June 2024

Ground magnetic field variations have been used to investigate ionospheric dynamics for more than a century. They are usually explained in terms of an electric circuit in the ionosphere driven by an electric field, but this is insufficient to explain how magnetic field disturbances are dynamically established. Here we explain and simulate how the ionosphere dynamically responds to magnetospheric forcing and how it leads to magnetic field deformation via Faraday's law. Our approach underscores the causal relationships, treating the magnetic field and velocity as primary variables (the B, v paradigm), whereas the electric field and current are derived, in contrast to the E, j paradigm commonly used in ionospheric physics. The simulation approach presented here could be used as an alternative to existing circuit‐based numerical models of magnetosphere‐ionosphere coupling.
Complex Martinique Intermediate‐Depth Earthquake Reactivates Early Atlantic Break‐Up Structures
Authors: Lindner Mike , Rietbrock Andreas , Bie Lidong , Gao Ya‐Jian , Goes Saskia , Frietsch Michael
Published: June 2024

Earthquakes that rupture several faults occur frequently within the shallow lithosphere but are rarely observed for intermediate‐depth events (70–300 km). On 29 November 2007, the Mw7.4 Martinique earthquake struck the Lesser Antilles Island Arc near the deep end of the Wadati‐Benioff‐Zone. The sparse regional seismic network of 2007 previously hampered a detailed examination of this unusually complex event. Here, we combine seismic data from different studies with regional moment tensor inversion results and 3D full‐waveform modeling. We show that the earthquake is a doublet consisting of dip‐slip and strike‐slip motion along two oblique structures, both activated under extensional stress along the strike of the slab. Comparison with tectonic reconstructions suggests that the earthquake ruptured along a re‐activated ridge‐transform segment of the subducted Proto‐Caribbean spreading ridge. The unprecedented resolution of the source process highlights the influence of pre‐existing structures on localizing slab deformation also at intermediate‐depth.
Kinetic‐Scale Current Sheets in the Solar Wind at 5 AU
Authors: Vasko I. Y. , Alimov K. , Phan T. D. , Mozer F. S. , Artemyev A. V.
Published: June 2024

We present statistical analysis of 16,903 current sheets (CSs) observed over 641 days aboard Ulysses spacecraft at 5 AU. We show that the magnetic field rotates across CSs through some shear angle, while only weakly varies in magnitude. The CSs are typically asymmetric with statistically different, though only by a few percent, magnetic field magnitudes at the CS boundaries. The data set is classified into about 90.6% non‐bifurcated and 9.4% bifurcated CSs. Most of the CSs are proton kinetic‐scale structures with the half‐thickness of non‐bifurcated and bifurcated CSs within respectively 200–2,000 km and 500–5,000 km or 0.5–5λp and 0.7–15λp in units of local proton inertial length. The amplitude of the current density, mostly parallel to magnetic field, is typically within 0.05–0.5 nA/m2 or 0.04–0.4JA in units of local Alfvén current density. The CSs demonstrate approximate scale‐invariance with the shear angle and current density amplitude scaling with the half‐thickness, and . The matching of the magnetic field rotation and compressibility observed within the CSs against those in ambient solar wind indicate that the CSs are produced by turbulence, inheriting its scale‐invariance and compressibility. The estimated asymmetry in plasma beta between the CS boundaries is shown to be insufficient to suppress magnetic reconnection through the diamagnetic drift of X‐line. The presented results will be of value for future comparative analysis of CSs observed at different distances from the Sun.
A Statistical Analysis of the Morphology of Storm‐Enhanced Density Plumes Over the North American Sector
Authors: Aa Ercha , Dzwill Patricia , Zhang Shun‐Rong , Erickson Philip J.
Published: June 2024

The storm‐enhanced density (SED) is a large‐scale midlatitude ionospheric electron density enhancement in the local afternoon sector, which exhibits substantial spatial gradients and thus can impose detrimental effects on modern navigation and communication systems, causing potential space weather hazards. This study has identified a comprehensive list of 49 SED events over the continental US and adjacent regions, by examining strong geomagnetic storms occurring between 2000 and 2023. The ground‐based Global Navigation Satellite System (GNSS) total electron content and data from a new TEC‐based ionospheric data assimilation system were used to analyze the characteristics of SED. For each derived SED events, we have quantified its morphology by employing a Gaussian function to parameterize key characteristics of the SED, such as the plume intensity, central longitude, and half‐width. A statistical analysis of SEDs was conducted for the first time to characterize their climatological features. We found that the SED distribution exhibits a higher peak intensity and a narrower width as geomagnetic activity strengthens. The peak intensity of SED has maximum values around the equinoxes in their seasonal distribution. Additionally, we observed a solar cycle dependence in the SED distribution, with more events occurring during the solar maximum and declining phases compared to the solar minimum. SED plumes exhibit a sub‐corotation feature with respect to the Earth, characterized by a westward drift speed between 50 and 400 m/s and a duration of 3–10 hr. These information advanced the current understanding of the spatial‐temporal variation of SED characteristics.
DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer
Authors: Dong Hongliang , Jia Weiyi , Meng Weijian , Zhang Rui , Qi Zhihong , Chen Zhuo , Xie Sophia , Min Jiang , Liu Liang , Shen Jie
Published: June 2024

Metabolic reprogramming has become increasingly important in tumor biology research. The glucose metabolic pathway is a major energy source and is often dysregulated in breast cancer. DAB2IP is widely reported to be a tumor suppressor that acts as a scaffold protein to suppress tumor malignancy in breast cancer. Interestingly, DAB2IP has also been found to be a potential regulator of glucose uptake; however, the exact mechanism remains unclear. In this study, we found that DAB2IP inhibited glucose uptake under hypoxia conditions in breast cancer cells by suppressing HIF-1α signals. Mechanically, DAB2IP interacted with the E3 ubiquitin ligase STUB1 via its PER domain, thus triggering STUB1 mediated HIF-1α ubiquitylation and degradation, and inhibit glucose metabolism and tumor progression. Deleting the PER domain abrogated the DAB2IP-related inhibitory effects on glucose uptake, intracellular ATP production, and lactic acid production in breast cancer cells. These findings elucidate the biological roles of DAB2IP in cancer-related glucose metabolism as well as a novel mechanism by which STUB1-driven HIF-1α ubiquitylated degradation is regulated in breast cancer.
Genetics of child aggression, a systematic review
Authors: Koyama Emiko , Kant Tuana , Takata Atsushi , Kennedy James L. , Zai Clement C.
Published: June 2024

Excessive and persistent aggressiveness is the most common behavioral problem that leads to psychiatric referrals among children. While half of the variance in childhood aggression is attributed to genetic factors, the biological mechanism and the interplay between genes and environment that results in aggression remains elusive. The purpose of this systematic review is to provide an overview of studies examining the genetics of childhood aggression irrespective of psychiatric diagnosis. PubMed, PsycINFO, and MEDLINE databases were searched using predefined search terms for aggression, genes and the specific age group. From the 652 initially yielded studies, eighty-seven studies were systematically extracted for full-text review and for further quality assessment analyses. Findings show that (i) investigation of candidate genes, especially of MAOA (17 studies), DRD4 (13 studies), and COMT (12 studies) continue to dominate the field, although studies using other research designs and methods including genome-wide association and epigenetic studies are increasing, (ii) the published articles tend to be moderate in sizes, with variable methods of assessing aggressive behavior and inconsistent categorizations of tandem repeat variants, resulting in inconclusive findings of genetic main effects, gene-gene, and gene-environment interactions, (iii) the majority of studies are conducted on European, male-only or male-female mixed, participants. To our knowledge, this is the first study to systematically review the effects of genes on youth aggression. To understand the genetic underpinnings of childhood aggression, more research is required with larger, more diverse sample sets, consistent and reliable assessments and standardized definition of the aggression phenotypes. The search for the biological mechanisms underlying child aggression will also benefit from more varied research methods, including epigenetic studies, transcriptomic studies, gene system and genome-wide studies, longitudinal studies that track changes in risk/ameliorating factors and aggression-related outcomes, and studies examining causal mechanisms.
Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer’s disease
Authors: Hofstra Bente M. , Kas Martien J. H. , Verbeek Dineke S.
Published: June 2024

There is growing evidence of a shared pathogenesis between Alzheimer’s disease and depression. Therefore, we aimed to further investigate their shared disease mechanisms. We made use of publicly available brain-specific eQTL data and gene co-expression networks of previously reported genetic loci associated with these highly comorbid disorders. No direct genetic overlap was observed between Alzheimer’s disease and depression in our dataset, but we did detect six shared brain-specific eQTL genes: SRA1, MICA, PCDHA7, PCDHA8, PCDHA10 and PCDHA13. Several pathways were identified as shared between Alzheimer’s disease and depression by conducting clustering pathway analysis on hippocampal co-expressed genes; synaptic signaling and organization, myelination, development, and the immune system. This study highlights trans-synaptic signaling and synaptoimmunology in the hippocampus as main shared pathomechanisms of Alzheimer’s disease and depression.
ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation
Authors: Licini Caterina , Morroni Gianluca , Lucarini Guendalina , Vitto Veronica Angela Maria , Orlando Fiorenza , Missiroli Sonia , D’Achille Gloria , Perrone Mariasole , Spadoni Tatiana , Graciotti Laura , Bigossi Giorgia , Provinciali Mauro , Offidani Annamaria , Mattioli-Belmonte Monica , Cirioni Oscar , Pinton Paolo , Simonetti Oriana , Marchi Saverio
Published: June 2024

Methicillin-resistant Staphylococcus aureus (MRSA) is the most common causative agent of acute bacterial skin and skin-structure infections (ABSSSI), one of the major challenges to the health system worldwide. Although the use of antibiotics as the first line of intervention for MRSA-infected wounds is recommended, important side effects could occur, including cytotoxicity or immune dysregulation, thus affecting the repair process. Here, we show that the oxazolidinone antibiotic linezolid (LZD) impairs wound healing by aberrantly increasing interleukin 1 β (IL-1β) production in keratinocytes. Mechanistically, LZD triggers a reactive oxygen species (ROS)-independent mitochondrial damage that culminates in increased tethering between the endoplasmic reticulum (ER) and mitochondria, which in turn activates the NLR family pyrin domain-containing 3 (NLRP3) inflammasome complex by promoting its assembly to the mitochondrial surface. Downregulation of ER-mitochondria contact formation is sufficient to inhibit the LZD-driven NLRP3 inflammasome activation and IL-1β production, restoring wound closure. These results identify the ER-mitochondria association as a key factor for NLRP3 activation and reveal a new mechanism in the regulation of the wound healing process that might be clinically relevant.
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival
Authors: Li Miaomiao , Huang Wenjing , Zhang Yuan , Du Yue , Zhao Shan , Wang Longhao , Sun Yaxin , Sha Beibei , Yan Jie , Ma Yangcheng , Tang Jinlu , Shi Jianxiang , Li Pei , Jia Lijun , Hu Tao , Chen Ping
Published: June 2024

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains largely elusive. In this study, we demonstrate that glucose deprivation, while not amino acid or serum starvation, transactivates the expression of DCAF1. This enhances the K48-linked polyubiquitination and proteasome-dependent degradation of Rheb, inhibits mTORC1 activity, induces autophagy, and facilitates cancer cell survival under glucose deprivation conditions. This study identified DCAF1 as a new cellular glucose sensor and uncovered new insights into mechanism of DCAF1-mediated inactivation of Rheb-mTORC1 pathway for promoting cancer cell survival in response to glucose deprivation.
Clathrin mediates membrane fission and budding by constricting membrane pores
Authors: Wei Lisi , Guo Xiaoli , Haimov Ehud , Obashi Kazuki , Lee Sung Hoon , Shin Wonchul , Sun Min , Chan Chung Yu , Sheng Jiansong , Zhang Zhen , Mohseni Ammar , Ghosh Dastidar Sudhriti , Wu Xin-Sheng , Wang Xin , Han Sue , Arpino Gianvito , Shi Bo , Molakarimi Maryam , Matthias Jessica , Wurm Christian A. , Gan Lin , Taraska Justin W. , Kozlov Michael M. , Wu Ling-Gang
Published: June 2024

Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, to form Ω-shape profiles and helix-forming proteins like dynamin to constrict Ω-profiles’ pores and thus mediate fission. Challenging this fundamental concept, we report that polymerized clathrin is required for Ω-profiles’ pore closure and that clathrin around Ω-profiles’ base/pore region mediates pore constriction/closure in neuroendocrine chromaffin cells. Mathematical modeling suggests that clathrin polymerization at Ω-profiles’ base/pore region generates forces from its intrinsically curved shape to constrict/close the pore. This new fission function may exert broader impacts than clathrin’s well-known coat-forming function during clathrin (coat)-dependent endocytosis, because it underlies not only clathrin (coat)-dependent endocytosis, but also diverse endocytic modes, including ultrafast, fast, slow, bulk, and overshoot endocytosis previously considered clathrin (coat)-independent in chromaffin cells. It mediates kiss-and-run fusion (fusion pore closure) previously considered bona fide clathrin-independent, and limits the vesicular content release rate. Furthermore, analogous to results in chromaffin cells, we found that clathrin is essential for fast and slow endocytosis at hippocampal synapses where clathrin was previously considered dispensable, suggesting clathrin in mediating synaptic vesicle endocytosis and fission. These results suggest that clathrin and likely other intrinsically curved coat proteins are a new class of fission proteins underlying vesicle budding and fusion. The half-a-century concept and studies that attribute vesicle-coat contents’ function to Ω-profile formation and classify budding as coat-protein (e.g., clathrin)-dependent or -independent may need to be re-defined and re-examined by considering clathrin’s pivotal role in pore constriction/closure.