bluuebunny/crossref_metadata_2025 huggingface dataset:
Macronutrient Intake in Adults Diagnosed with Metabolic Syndrome: Using the Health Examinee (HEXA) Cohort
Authors: Park Hyerim , Kityo Anthony , Kim Yeonjin , Lee Sang-Ah
Published: December 2021

Macronutrient intake is important in the prevention and management of metabolic syndrome (MetS). This study aimed to evaluate total energy and macronutrient intake of participants diagnosed with MetS at recruitment of the health examinees (HEXA) cohort, considering the plant and animal sources of each macronutrient. We included 130,423 participants aged 40–69 years for analysis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated to evaluate the intake of macronutrients stratified by gender. Energy and macronutrient intake were estimated by linking food frequency questionnaire data to the Korean food composition database, and were calculated separately for plant and animal foods. Low energy (men: OR = 0.95, 95% CI: 0.92–0.98; women: OR = 0.97, 95% CI: 0.95–0.99), and fat intake (men: OR = 0.93, 95% CI: 0.90–0.96; women: OR = 0.80, 95% CI: 0.77–0.83) were observed. Only postmenopausal women had lower intake of total energy (OR = 0.95, 95% CI: 0.92–0.97), whereas low fat intake was observed in all women (OR = 0.80, 95% CI: 0.77–0.83). For carbohydrate intake, the OR were 1.14 (95% CI: 1.08–1.22) and 1.17 (95% CI: 1.08–1.27) among women in their 50s and 60s, respectively. Protein intake was low (OR = 0.90, 95% CI: 0.86–0.95; and OR = 0.88, 95% CI: 0.82–0.94) among women in their 50s and 60s, respectively. High intake of plant carbohydrates in women (OR = 1.16, 95% CI: 1.12–1.20), and plant protein in both genders (OR = 1.09, 95% CI: 1.05–1.13) were observed, but low intake of total energy, fat, and animal-source carbohydrates in both genders was also observed. Fat intake was low regardless of food source. In conclusion, high consumption of plant-source macronutrients, and low consumption of animal-source macronutrients was observed in Korean adults diagnosed with MetS. Attention should be directed to plant sources of carbohydrates and proteins when designing population interventions for metabolic syndrome reduction in Korea.
Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT
Authors: Zhang Man , Ye Lili , Cheng Chuanjing , Shen Fukui , Niu Lin , Hou Yuanyuan , Bai Gang
Published: December 2021

Mounting evidence has shown that single-targeted therapy might be inadequate to achieve satisfactory effects. Thus, drug combinations are gaining attention as they can regulate multiple targets to obtain more beneficial effects. Heat shock protein 90 (HSP90) is a molecular chaperone that assists the protein assembly and folding of client proteins and maintains their stability. Interfering with the interaction between HSP90 and its client proteins by inhibiting the latter’s activity may offer a new approach toward combination therapy. The HSP90 client protein AKT plays an important role in the inflammatory response syndrome caused by infections. In this study, the dietary flavone baicalein was identified as a novel inhibitor of HSP90 that targeted the N-terminal ATP binding pocket of HSP90 and hindered the chaperone cycle, resulting in AKT degradation. Combining baicalein with genipin, which was extracted from Gardenia jasminoides, could inhibit the pleckstrin homology domain of AKT, significantly increasing the anti-inflammatory effects both in vitro and in vivo. This synergistic effect was attributed to the reduction in AKT expression and phosphorylation. Thus, elucidating the mechanism underlying this effect will provide a new avenue for the clinical application and development of synergistic anti-inflammatory drugs.
Breakfast Habits and Associations with Fruit and Vegetable Intake, Physical Activity, Sedentary Time, and Screen Time among Swedish 13–14-Year-Old Girls and Boys
Authors: Helgadóttir Björg , Baurén Hanna , Kjellenberg Karin , Ekblom Örjan , Nyberg Gisela
Published: December 2021

This study explored whether breakfast habits were associated with intake of fruits and vegetables, minutes in moderate-to-vigorous physical activity (MVPA), minutes spent sedentary, and screen time among adolescents. Cross-sectional data were collected among 13–14-year-old boys and girls (n = 1139). Breakfast habits and screen time were determined via questionnaire, fruit and vegetable intake were determined through dietary recall, and physical activity and sedentary time were determined via accelerometers. Multilevel mixed models and general estimation equation models were applied. Almost 40% of participants skipped breakfast at least one day of the week. Participants with irregular breakfast habits on weekdays had lower fruit and vegetable consumption by 26.7 g (95% CI = −49.3, −5.9) while irregular breakfast habits during the whole week were associated with higher levels of screen time (OR = 1.5, 95% CI = 1.1, 2.1) compared to regular breakfast habits. Girls with irregular breakfast habits on weekdays had 7.7 min more sedentary time (95% CI = 0.8, 15.7) than girls with regular breakfast habits, while the opposite was found in boys (β = −13.3, 95% CI = −25.3, −2.6)). No significant associations were found for MVPA. Regular breakfast habits should be encouraged, as they might contribute to a higher intake of fruit and vegetables and are associated with lower levels of screen time, although further studies are necessary to establish causation.
Iodine: Its Role in Thyroid Hormone Biosynthesis and Beyond
Authors: Sorrenti Salvatore , Baldini Enke , Pironi Daniele , Lauro Augusto , D’Orazi Valerio , Tartaglia Francesco , Tripodi Domenico , Lori Eleonora , Gagliardi Federica , Praticò Marianna , Illuminati Giulio , D’Andrea Vito , Palumbo Piergaspare , Ulisse Salvatore
Published: December 2021

The present review deals with the functional roles of iodine and its metabolism. The main biological function of iodine concerns its role in the biosynthesis of thyroid hormones (THs) by the thyroid gland. In addition, however, further biological roles of iodine have emerged. Precisely, due to its significant action as scavenger of reactive oxygen species (ROS), iodine is thought to represent one of the oldest antioxidants in living organisms. Moreover, iodine oxidation to hypoiodite (IO−) has been shown to possess strong bactericidal as well as antiviral and antifungal activity. Finally, and importantly, iodine has been demonstrated to exert antineoplastic effects in human cancer cell lines. Thus, iodine, through the action of different tissue-specific peroxidases, may serve different evolutionarily conserved physiological functions that, beyond TH biosynthesis, encompass antioxidant activity and defense against pathogens and cancer progression.
HER2 Aberrations in Non-Small Cell Lung Cancer: From Pathophysiology to Targeted Therapy
Authors: Vathiotis Ioannis A. , Charpidou Andriani , Gavrielatou Niki , Syrigos Konstantinos N.
Published: December 2021

While human epidermal growth factor receptor 2 (HER2) aberrations have long been described in patients with non-small cell lung cancer (NSCLC), they have only recently been effectively targeted. Unlike patients with breast cancer, NSCLC patients can harbor either HER2-activating mutations or HER2 amplification coupled with protein overexpression. The latter has also been the case for patients with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). As preclinical data continue to accumulate, clinical trials evaluating novel agents that target HER2 have produced promising preliminary results. Here, we review existing data on HER2 aberrations in NSCLC. Starting from HER2 biology in normal and disease processes, we summarize discrepancies in HER2 diagnostic assays between breast cancer and NSCLC. Finally, to dissect the therapeutic implications of HER2-activating mutations versus gene amplification and/or protein overexpression, we present data from prospective clinical trials that have employed distinct classes of agents to target HER2 in patients with NSCLC.
Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid
Authors: Pflégr Václav , Maixnerová Jana , Stolaříková Jiřina , Pál Adrián , Korduláková Jana , Trejtnar František , Vinšová Jarmila , Krátký Martin
Published: December 2021

The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and synthesized more lipophilic esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid, obtained from antitubercular drug isoniazid, with various alcohols, phenols and thiols, including several drugs, using carbodiimide-mediated coupling. Nineteen new esters were evaluated as potential antimycobacterial agents against drug-sensitive Mycobacterium tuberculosis (Mtb.) H37Rv, Mycobacterium avium and Mycobacterium kansasii. Selected derivatives were also tested for inhibition of multidrug-resistant (MDR) Mtb., and their mechanism of action was investigated. The esters exhibited high activity against Mtb. (minimum inhibitory concentrations, MIC, from ≤0.125 μM), M. kansasii, M. avium as well as MDR strains (MIC from 0.25, 32 and 8 µM, respectively). The most active mutual derivatives were derived from 4-chloro/phenoxy-phenols, triclosan, quinolin-8-ol, naphthols and terpene alcohols. The experiments identified enoyl-acyl carrier protein reductase (InhA), and thus mycobacterial cell wall biosynthesis, as the main target of the molecules that are activated by KatG, but for some compounds can also be expected adjunctive mechanism(s). Generally, the mutual esters have also avoided cytotoxicity and are promising hits for the discovery of antimycobacterial drugs with improved properties compared to parent isoniazid.
Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System
Authors: Verkhovskii Roman , Ermakov Alexey , Sindeeva Olga , Prikhozhdenko Ekaterina , Kozlova Anastasiia , Grishin Oleg , Makarkin Mikhail , Gorin Dmitry , Bratashov Daniil
Published: December 2021

Drug carriers based on polyelectrolyte microcapsules remotely controlled with an external magnetic field are a promising drug delivery system. However, the influence of capsule parameters on microcapsules’ behavior in vivo is still ambiguous and requires additional study. Here, we discuss how the processes occurring in the blood flow influence the circulation time of magnetic polyelectrolyte microcapsules in mouse blood after injection into the blood circulatory system and their interaction with different blood components, such as WBCs and RBCs. The investigation of microcapsules ranging in diameter 1–5.5 μm allowed us to reveal the dynamics of their filtration by vital organs, cytotoxicity, and hemotoxicity, which is dependent on their size, alongside the efficiency of their interaction with the magnetic field. Our results show that small capsules have a long circulation time and do not affect blood cells. In contrast, the injection of large 5.5 μm microcapsules leads to fast filtration from the blood flow, induces the inhibition of macrophage cell line proliferation after 48 h, and causes an increase in hemolysis, depending on the carrier concentration. The obtained results reveal the possible directions of fine-tuning microcapsule parameters, maximizing capsule payload without the side effects for the blood flow or the blood cells.
The Effect of Zn-Substitution on the Morphological, Magnetic, Cytotoxic, and In Vitro Hyperthermia Properties of Polyhedral Ferrite Magnetic Nanoparticles
Authors: Fizesan Ionel , Iacovita Cristian , Pop Anca , Kiss Bela , Dudric Roxana , Stiufiuc Rares , Lucaciu Constantin Mihai , Loghin Felicia
Published: December 2021

The clinical translation of magnetic hyperthermia (MH) needs magnetic nanoparticles (MNPs) with enhanced heating properties and good biocompatibility. Many studies were devoted lately to the increase in the heating power of iron oxide MNPs by doping the magnetite structure with divalent cations. A series of MNPs with variable Zn/Fe molar ratios (between 1/10 and 1/1) were synthesized by using a high-temperature polyol method, and their physical properties were studied with different techniques (Transmission Electron Microscopy, X-ray diffraction, Fourier Transform Infrared Spectroscopy). At low Zn doping (Zn/Fe ratio 1/10), a significant increase in the saturation magnetization (90 e.m.u./g as compared to 83 e.m.u./g for their undoped counterparts) was obtained. The MNPs’ hyperthermia properties were assessed in alternating magnetic fields up to 65 kA/m at a frequency of 355 kHz, revealing specific absorption rates of up to 820 W/g. The Zn ferrite MNPs showed good biocompatibility against two cell lines (A549 cancer cell line and BJ normal cell line) with a drop of only 40% in the viability at the highest dose used (500 μg/cm2). Cellular uptake experiments revealed that the MNPs enter the cells in a dose-dependent manner with an almost 50% higher capacity of cancer cells to accommodate the MNPs. In vitro hyperthermia data performed on both cell lines indicate that the cancer cells are more sensitive to MH treatment with a 90% drop in viability after 30 min of MH treatment at 30 kA/m for a dose of 250 μg/cm2. Overall, our data indicate that Zn doping of iron oxide MNPs could be a reliable method to increase their hyperthermia efficiency in cancer cells.
Preparation and Optimization of Garlic Oil/Apple Cider Vinegar Nanoemulsion Loaded with Minoxidil to Treat Alopecia
Authors: Rizg Waleed Y. , Hosny Khaled M. , Elgebaly Samar S. , Alamoudi Abdulmohsin J. , Felimban Raed I. , Tayeb Hossam H. , Alharbi Majed , Bukhary Haitham A. , Abualsunun Walaa A. , Almehmady Alshaimaa M. , Khallaf Rasha A.
Published: December 2021

Alopecia areata is a scarless, localized hair loss disorder that is typically treated with topical formulations that ultimately only further irritate the condition. Hence, the goal of this study was to develop a nanoemulsion with a base of garlic oil (GO) and apple cider vinegar (APCV) and loaded with minoxidil (MX) in order to enhance drug solubilization and permeation through skin. A distance coordinate exchange quadratic mixture design was used to optimize the proposed nanoemulsion. Span 20 and Tween 20 mixtures were used as the surfactant, and Transcutol was used as the co-surfactant. The developed formulations were characterized for their droplet size, minoxidil steady-state flux (MX Jss) and minimum inhibitory concentration (MIC) against Propionibacterium acnes. The optimized MX-GO-APCV nanoemulsion had a droplet size of 110 nm, MX Jss of 3 μg/cm2 h, and MIC of 0.275 μg/mL. The optimized formulation acquired the highest ex vivo skin permeation parameters compared to MX aqueous dispersion, and varying formulations lacked one or more components of the proposed nanoemulsion. GO and APCV in the optimized formulation had a synergistic, enhancing activity on the MX permeation across the skin membrane, and the percent permeated increased from 12.7% to 41.6%. Finally, the MX-GO-APCV nanoemulsion followed the Korsmeyer–Peppas model of diffusion, and the value of the release exponent (n) obtained for the formulations was found to be 1.0124, implying that the MX permeation followed Super case II transport. These results demonstrate that the MX-GO-APCV nanoemulsion formulation could be useful in promoting MX activity in treating alopecia areata.
Controlled and Local Delivery of Antibiotics by 3D Core/Shell Printed Hydrogel Scaffolds to Treat Soft Tissue Infections
Authors: Akkineni Ashwini Rahul , Spangenberg Janina , Geissler Michael , Reichelt Saskia , Buechner Hubert , Lode Anja , Gelinsky Michael
Published: December 2021

Soft tissue infections in open fractures or burns are major cause for high morbidity in trauma patients. Sustained, long-term and localized delivery of antimicrobial agents is needed for early eradication of these infections. Traditional (topical or systemic) antibiotic delivery methods are associated with a variety of problems, including their long-term unavailability and possible low local concentration. Novel approaches for antibiotic delivery via wound coverage/healing scaffolds are constantly being developed. Many of these approaches are associated with burst release and thus seldom maintain long-term inhibitory concentrations. Using 3D core/shell extrusion printing, scaffolds consisting of antibiotic depot (in the core composed of low concentrated biomaterial ink 3% alginate) surrounded by a denser biomaterial ink (shell) were fabricated. Denser biomaterial ink (composed of alginate and methylcellulose or alginate, methylcellulose and Laponite) retained scaffold shape and modulated antibiotic release kinetics. Release of antibiotics was observed over seven days, indicating sustained release characteristics and maintenance of potency. Inclusion of Laponite in shell, significantly reduced burst release of antibiotics. Additionally, the effect of shell thickness on release kinetics was demonstrated. Amalgamation of such a modular delivery system with other biofabrication methods could potentially open new strategies to simultaneously treat soft tissue infections and aid wound regeneration.
Multifunctional Gelatin/Chitosan Electrospun Wound Dressing Dopped with Undaria pinnatifida Phlorotannin-Enriched Extract for Skin Regeneration
Authors: Ferreira Carolina A. M. , Januário Adriana P. , Félix Rafael , Alves Nuno , Lemos Marco F. L. , Dias Juliana R.
Published: December 2021

The similarities of electrospun fibers with the skin extracellular matrix (ECM) make them promising structures for advanced wound dressings. Moreover, infection and resistance in wounds are a major health concern that may be reduced with antibacterial wound dressings. In this work, a multifunctional wound dressing was developed based on gelatin/chitosan hybrid fibers dopped with phlorotannin-enrich extract from the seaweed Undaria pinnatifida. The intrinsic electrospun structure properties combined with the antimicrobial and anti-inflammatory properties of phlorotannin-enrich extract will enhance the wound healing process. Electrospun meshes were produced by incorporating 1 or 2 wt% of extract, and the structure without extract was used as a control. Physico-chemical, mechanical, and biological properties were evaluated for all conditions. Results demonstrated that all developed samples presented a homogenous fiber deposition with the average diameters closer to the native ECM fibrils, and high porosities (~90%) that will be crucial to control the wound moist environment. According to the tensile test assays, the incorporation of phlorotannin-enriched extract enhances the elastic performance of the samples. Additionally, the extract incorporation made the structure stable over time since its in vitro degradation rates decreased under enzymatic medium. Extract release profile demonstrated a longstanding delivery (up to 160 days), reaching a maximum value of ~98% over time. Moreover, the preliminary antimicrobial results confirm the mesh’s antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus. In terms of biological characterization, no condition presented cytotoxicity effects on hDNF cells, allowing their adhesion and proliferation over 14 days, except the condition of 2 wt% after 7 days. Overall, the electrospun structure comprising phlorotannins-enriched extract is a promising bioactive structure with potential to be used as a drug delivery system for skin regeneration by reducing the bacterial infection in the wound bed.
Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission
Authors: Monchaux De Oliveira Camille , De Smedt-Peyrusse Véronique , Morael Jennifer , Vancassel Sylvie , Capuron Lucile , Gaudout David , Pourtau Line , Castanon Nathalie
Published: December 2021

Depressive disorders are a major public health concern. Despite currently available treatment options, their prevalence steadily increases, and a high rate of therapeutic failure is often reported, together with important antidepressant-related side effects. This highlights the need to improve existing therapeutic strategies, including by using nutritional interventions. In that context, saffron recently received particular attention for its beneficial effects on mood, although the underlying mechanisms are poorly understood. This study investigated in mice the impact of a saffron extract (Safr’Inside™; 6.25 mg/kg, per os) on acute restraint stress (ARS)-induced depressive-like behavior and related neurobiological alterations, by focusing on hypothalamic–pituitary–adrenal axis, inflammation-related metabolic pathways, and monoaminergic systems, all known to be altered by stress and involved in depressive disorder pathophysiology. When given before stress onset, Safr’Inside administration attenuated ARS-induced depressive-like behavior in the forced swim test. Importantly, it concomitantly reversed several stress-induced monoamine dysregulations and modulated the expression of key enzymes of the kynurenine pathway, likely reducing kynurenine-related neurotoxicity. These results show that saffron pretreatment prevents the development of stress-induced depressive symptoms and improves our understanding about the underlying mechanisms, which is a central issue to validate the therapeutic relevance of nutritional interventions with saffron in depressed patients.
Identification of microRNAs Responding to Aluminium, Cadmium and Salt Stresses in Barley Roots
Authors: Kuang Liuhui , Yu Jiahua , Shen Qiufang , Fu Liangbo , Wu Liyuan
Published: December 2021

Plants are frequently exposed to various abiotic stresses, including aluminum, cadmium and salinity stress. Barley (Hordeum vulgare) displays wide genetic diversity in its tolerance to various abiotic stresses. In this study, small RNA and degradome libraries from the roots of a barley cultivar, Golden Promise, treated with aluminum, cadmium and salt or controls were constructed to understand the molecular mechanisms of microRNAs in regulating tolerance to these stresses. A total of 525 microRNAs including 198 known and 327 novel members were identified through high-throughput sequencing. Among these, 31 microRNAs in 17 families were responsive to these stresses, and Gene Ontology (GO) analysis revealed that their targeting genes were mostly highlighted as transcription factors. Furthermore, five (miR166a, miR166a-3p, miR167b-5p, miR172b-3p and miR390), four (MIR159a, miR160a, miR172b-5p and miR393) and three (miR156a, miR156d and miR171a-3p) microRNAs were specifically responsive to aluminum, cadmium and salt stress, respectively. Six miRNAs, i.e., miR156b, miR166a-5p, miR169a, miR171a-5p, miR394 and miR396e, were involved in the responses to the three stresses, with different expression patterns. A model of microRNAs responding to aluminum, cadmium and salt stresses was proposed, which may be helpful in comprehensively understanding the mechanisms of microRNAs in regulating stress tolerance in barley.
Numerical Study of Customized Artificial Cornea Shape by Hydrogel Biomaterials on Imaging and Wavefront Aberration
Authors: Ma Yu-Chi , Hsieh Chang-Tsung , Lin Yu-Hsiang , Dai Chi-An , Li Jia-Han
Published: December 2021

The blindness caused by cornea diseases has exacerbated many patients all over the world. The disadvantages of using donor corneas may cause challenges to recovering eye sight. Developing artificial corneas with biocompatibility may provide another option to recover blindness. The techniques of making individual artificial corneas that fit the biometric parameters for each person can be used to help these patients effectively. In this study, artificial corneas with different shapes (spherical, aspherical, and biconic shapes) are designed and they could be made by two different hydrogel polymers that form an interpenetrating polymer network for their excellent mechanical strength. Two designed cases for the artificial corneas are considered in the simulations: to optimize the artificial cornea for patients who still wear glasses and to assume that the patient does not wear glasses after transplanting with the optimized artificial cornea. The results show that the artificial corneas can efficiently decrease the imaging blur. Increasing asphericity of the current designed artificial corneas can be helpful for the imaging corrections. The differences in the optical performance of the optimized artificial corneas by using different materials are small. It is found that the optimized artificial cornea can reduce the high order aberrations for the second case.
Rice Husk Ash-Based Geopolymer Binder: Compressive Strength, Optimize Composition, FTIR Spectroscopy, Microstructural, and Potential as Fire-Retardant Material
Authors: Mohd Basri Mohd Salahuddin , Mustapha Faizal , Mazlan Norkhairunnisa , Ishak Mohd Ridzwan
Published: December 2021

Compressive strength is an important property in construction material, particularly for thermal insulation purposes. Although the insulation materials possess high fire-retardant characteristics, their mechanical properties are relatively poor. Moreover, research on the correlation between fire-retardant and compressive strength of rice husk ash (RHA)-based geopolymer binder (GB) is rather limited. In addition, previous studies on RHA-based GB used the less efficient one-factor-at-a-time (OFAT) approach. In understanding the optimum value and significant effect of factors on the compressive strength, it was deemed necessary to employ statistical analysis and a regression coefficient model (mathematical model). The objective of the study is to determine the effect of different material behavior, namely brittle and ductile, on the compressive strength properties and the optimum material formulation that can satisfy both compressive strength and fire-retardant properties. The factors chosen for this study were the rice husk ash/activated alkaline solution (RHA/AA) ratio and the sodium hydroxide (NaOH) concentration. Compressive strength and fire-retardant tests were conducted as part of the experiments, which were designed and analyzed using the response surface methodology (RSM). The microstructure of geopolymer samples was investigated using a scanning electron microscope (SEM). Results showed that RHA/AA ratio was highly significant (p < 0.000) followed by NaOH concentration (p < 0.024). When the RHA/AA ratio was at 0.7 to 0.8 and the NaOH concentration was between 12 and 14 M, high compressive strength above 28 MPa was recorded. Optimum compressive strength of approximately 47 MPa was achieved when the RHA/AA ratio and NaOH concentration were 0.85 and 14 M, respectively. Brittle samples with low Si/Al ratio of 88.95 were high in compressive strength, which is 33.55 MPa, and showed a high degree of geopolymerization. Inversely, ductile samples showed low compressive strength and degree of geopolymerization. Water content within the geopolymer binder had a major effect on its fire-retardant properties. Semi-ductile GB showed the best fire-retardant properties, followed by semi-brittle and brittle GB. Using RHA as an aluminosilicate source has proven to be a promising alternative.
Charge Storage and Solar Rechargeable Battery Devices Based on Electrodes Electrochemically Modified with Conducting Polymer Nanowires
Authors: Ramírez Andrés Mauricio , Gacitúa Manuel Alejandro , Díaz Fernando Raúl , del Valle María Angélica
Published: December 2021

In this work, the use of nanostructured conducting polymer deposits on energy-storing devices is described. The cathode and the anode are electrochemically modified with nanowires of polypyrrole and poly(3,4-ethylenedioxythiophene), respectively, prepared after the use of a mesoporous silica template. The effect of aqueous or ionic liquid medium is assayed during battery characterization studies. The nanostructured device greatly surpasses the performance of the bulk configuration in terms of specific capacity, energy, and power. Moreover, compared with devices found in the literature with similar designs, the nanostructured device prepared here shows better battery characteristics, including cyclability. Finally, considering the semi-conducting properties of the components, the device was adapted to the design of a solar-rechargeable device by the inclusion of a titanium oxide layer and cis-bis(isothiocyanate)-bis(2,2′-bipyridyl-4,4′-dicarboxylate) ruthenium (II) dye. The device proved that the nanostructured design is also appropriate for the implementation of solar-rechargeable battery, although its performance still requires further optimization.
Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair
Authors: Neto Ana S. , Pereira Patrícia , Fonseca Ana C. , Dias Carla , Almeida Mariana C. , Barros Inês , Miranda Catarina O. , de Almeida Luís P. , Morais Paula V. , Coelho Jorge F. J. , Ferreira José M. F.
Published: December 2021

The present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers—poly(ε-caprolactone) (PCL) or poly(ester urea) (PEU)—loaded with an antibiotic drug, Rifampicin (RFP). The amounts of RFP incorporated into the PCL and PEU-coated scaffolds were 0.55 ± 0.04 and 0.45 ± 0.02 wt%, respectively. The in vitro drug release profiles in phosphate buffered saline over 6 days were characterized by a burst release within the first 8h, followed by a sustained release. The Korsmeyer–Peppas model showed that RFP release was controlled by polymer-specific non-Fickian diffusion. A faster burst release (67.33 ± 1.48%) was observed for the PCL-coated samples, in comparison to that measured (47.23 ± 0.31%) for the PEU-coated samples. The growth inhibitory activity against Escherichia coli and Staphylococcus aureus was evaluated. Although the RFP-loaded scaffolds were effective in reducing bacterial growth for both strains, their effectiveness depends on the particular bacterial strain, as well as on the type of polymer coating, since it rules the drug release behavior. The low antibacterial activity demonstrated by the BCP-PEU-RFP scaffold against E. coli could be a consequence of the lower amount of RFP that is released from this scaffold, when compared with BCP-PCL-RFP. In vitro studies showed excellent cytocompatibility, adherence, and proliferation of human mesenchymal stem cells on the BCP-PEU-RFP scaffold surface. The fabricated highly porous scaffolds that could act as an antibiotic delivery system have great potential for applications in bone regeneration and tissue engineering, while preventing bacterial infections.
Suberinic Acids as a Potential Feedstock for Polyol Synthesis: Separation and Characterization
Authors: Rizikovs Janis , Godina Daniela , Makars Raimonds , Paze Aigars , Abolins Arnis , Fridrihsone Anda , Meile Kristine , Kirpluks Mikelis
Published: December 2021

Global sustainability challenges prompt the world to modify its strategies and shift from a fossil-fuel-based economy to a bio-resources-based one and to the production of renewable biomass chemicals. Depolymerized suberinic acids (SA) were considered as an alternative resource to develop bio-polyols that can be further used in polyurethane (PU) material production. Birch (Betula pendula) outer bark was used as a raw material to obtain the SA, extracted with ethanol, and depolymerized with potassium hydroxide ethanol solution. By acidifying the filtrate to pH 5.0, 3.0, and 1.0 and drying it at 50 °C and 130 °C, 12 different SA potential feedstocks were obtained and characterized using chemical (total phenolics content, solubility in DMSO, acid, hydroxyl, and saponification number) and instrumental analytical methods (GC-MS, SEC-RID, DSC, and FTIR). Several bio-polyols were synthesized from the SA sample acidified to pH 1 and dried at 130 °C. Acid number and hydroxyl number values, the apparent viscosity and moisture content were measured. It was concluded that SA have a high enough saponification and acid value to investigate the polyol synthesis route via the esterification reaction. Moreover, SA had OH groups in their structure, which can be exploited for PU material development. The majority of SA compounds had relatively low molecular weight with <1300 Da that are suited for bio-polyol synthesis applied for rigid PU foam development. The synthesized bio-polyols had high hydroxyl number values necessary for bio-polyols to be used for rigid PU foam production.
The Thermo-Oxidative Behavior of Cotton Coated with an Intumescent Flame Retardant Glycine-Derived Polyamidoamine: A Multi-Technique Study
Authors: Forte Claudia , Alongi Jenny , Beduini Alessandro , Borsacchi Silvia , Calucci Lucia , Carosio Federico , Ferruti Paolo , Ranucci Elisabetta
Published: December 2021

Linear polyamidoamines (PAAs) derived from the polyaddition of natural α-amino acids and N,N′-methylene bis(acrylamide) are intumescent flame retardants for cotton. Among them, the glycine-derived M-GLY extinguished the flame in horizontal flame spread tests at 4% by weight add-on. This paper reports on an extensive study aimed at understanding the molecular-level transformations of M-GLY-treated cotton upon heating in air at 300 °C, 350 °C and 420 °C. Thermogravimetric analysis (TGA) identified different thermal-oxidative decomposition stages and, coupled to Fourier transform infrared spectroscopy, allowed the volatile species released upon heating to be determined, revealing differences in the decomposition pattern of treated and untreated cotton. XPS analysis of the char residues of M-GLY-treated cotton revealed the formation of aromatic nanographitic char at lower temperature with respect to untreated cotton. Raman spectroscopy of the char residues provided indications on the degree of graphitization of treated and untreated cotton at the three reference temperatures. Solid state 13C nuclear magnetic resonance spectroscopy (NMR) provided information on the char structure as a function of the treatment temperature, clearly indicating that M-GLY favors the carbonization of cotton with the formation of more highly condensed aromatic structures.
Numerical Study of the Effect of Thixotropy on Extrudate Swell
Authors: Spanjaards Michelle , Peters Gerrit , Hulsen Martien , Anderson Patrick
Published: December 2021

The extrusion of highly filled elastomers is widely used in the automotive industry. In this paper, we numerically study the effect of thixotropy on 2D planar extrudate swell for constant and fluctuating flow rates, as well as the effect of thixotropy on the swell behavior of a 3D rectangular extrudate for a constant flowrate. To this end, we used the Finite Element Method. The state of the network structure in the material is described using a kinetic equation for a structure parameter. Rate and stress-controlled models for this kinetic equation are compared. The effect of thixotropy on extrudate swell is studied by varying the damage and recovery parameters in these models. It was found that thixotropy in general decreases extrudate swell. The stress-controlled approach always predicts a larger swell ratio compared to the rate-controlled approach for the Weissenberg numbers studied in this work. When the damage parameter in the models is increased, a less viscous fluid layer appears near the die wall, which decreases the swell ratio to a value lower than the Newtonian swell ratio. Upon further increasing the damage parameter, the high viscosity core layer becomes very small, leading to an increase in the swell ratio compared to smaller damage parameters, approaching the Newtonian value. The existence of a low-viscosity outer layer and a high-viscosity core in the die have a pronounced effect on the swell ratio for thixotropic fluids.
Prioritization of Challenges for the Effectuation of Sustainable Additive Manufacturing: A Case Study Approach
Authors: Alsaadi Naif
Published: December 2021

Additive manufacturing (AM) is gaining significant importance, as demand for customized products is increasing nowadays. AM is one of the disruptive technologies of Industry 4.0, which can reduce waste generation, enabling sustainability. The adoption of sustainable practices in the manufacturing sector is due to the need of the current scenario to minimize harmful emissions and for human wellbeing. In this regard, AM technologies are integrated with sustainable manufacturing concepts to contribute toward sustainable AM (SAM), with various benefits from the design, manufacturing, use, and EoL perspectives. Still, many sustainability issues are associated with AM processes, namely limited speed and the uncertain performance of fabricated parts. From this viewpoint, it is essential to analyze the challenges associated with adopting SAM practices. This article presents identification and analysis of the potential challenges associated with adopting SAM practices. Fifteen SAM challenges have been identified from the literature survey and analyzed using the “Gray Technique for Order of Preference by Similarity to Ideal Solution” (G-TOPSIS) approach. The priority order of the challenges has been identified. The study identified that “training towards SAM benefits” and “limited materials recycling potential” were the significant challenges in adopting SAM practices in the manufacturing sector. The present study will help industry practitioners, decision makers, and researchers effectively analyze the challenges associated with SAM for its effective implementation. Researchers can utilize the findings of the study for establishing the guidelines for the adoption of SAM.
A Multi-Criteria Decision-Making Approach to Evaluate Different UVC/H2O2 Systems in Wastewater Treatment
Authors: Cunha Isadora Luiza Climaco , Vieira Jose Geraldo Vidal , Kulay Luiz
Published: December 2021

High azoxystrobin (AZO), difenoconazole (DFZ), and imidacloprid (IMD) pesticide removal rates in sixteen bench-scale experiments concerning tomato washing water treatment were obtained through a UVC/H2O2 advanced oxidative process. Experimental conditions ([H2O2]0) and irradiance (EUVC) were optimized for higher degradation rates (pseudo-first-order reaction). To consider both economic aspects and environmental impacts when defining the treatment technology, as well as technological requirements, this study applied a multi-criteria decision-making method (MCDM) to assess and differentiate similar UVC/H2O2 process configurations. This allowed for the identification of the cheapest experimental arrangement with the lowest associated environmental impacts, coupled to the highest degradation rate (kIMD). After consulting experts to determine the importance of the applied criteria and measuring alternative performances, experiment E7 ([H2O2]0 = 43.5 mg L−1; EUVC = 15.0 W m−2; kIMD = 0.236 s−1) was determined as meeting the three criteria in a balanced manner. Although E7′s technological performance regarding degradation rate did not achieve the best individual result, it presented the lowest impacts and costs among the analyzed series, although alternatives are sensitive to decision-maker priorities. This study considered different factors of a process displaying potential industrial applications still in the design stage to achieve a more efficient and balanced solution.
Performance Evaluation of Solar Power Plants: A Review and a Case Study
Authors: Makkiabadi Mahmoud , Hoseinzadeh Siamak , Taghavirashidizadeh Ali , Soleimaninezhad Mohsen , Kamyabi Mohammadmahdi , Hajabdollahi Hassan , Majidi Nezhad Meysam , Piras Giuseppe
Published: December 2021

The world’s electricity generation has increased with renewable energy technologies such as solar (solar power plant), wind energy (wind turbines), heat energy, and even ocean waves. Iran is in the best condition to receive solar radiation due to its proximity to the equator (25.2969° N). In 2020, Iran was able to supply only 900 MW (about 480 solar power plants and 420 MW home solar power plants) of its electricity demand from solar energy, which is very low compared to the global average. Yazd, Fars, and Kerman provinces are in the top ranks of Iran, with the production of approximately 68, 58, and 47 MW using solar energy, respectively. Iran also has a large area of vacant land for the construction of solar power plants. In this article, the amount of electricity generation using solar energy in Iran is studied. In addition, the construction of a 10 MW power plant in the city of Sirjan is economically and technically analyzed. The results show that with US$16.14 million, a solar power plant can be built in the Sirjan region, and the initial capital will be returned in about four years. The results obtained using Homer software show that the highest maximum power generation is in July.
The Strategy of Universal-Design Thinking in Architecturally Innovative Product Development
Authors: Gao Chenhui , Lin Kai-Chieh , Wu Zheng-Yi
Published: December 2021

Universal design, as an important concept in product development, has been gradually implemented in various industries and firms, but most of the applications are aimed at the incremental innovation of product design. However, considering the differentiation of product types, the design factors are varied and not precise, which makes it difficult to effectively implement the existing universal-design principles in specific product designs when facing architecturally innovative product development, which leads to an increasing amount of time and resources. This study, with an umbrella stand as an example, proposes to design a new universal-design scale by combining the attributes of the umbrella stand, the existing universal-design principles and the usability principles at the beginning of the design. Then, through interviews and user surveys, cluster analysis is used to screen the products and refine the design factors. In addition, with the Quantification Type I, the universal-design principles and design factors are matched effectively in order to obtain the weight differences of the product design factors and eliminate unsuitable design factors, in order to guide product design. Finally, the universal umbrella-stand-design case is completed for verification. The results show that the universal umbrella stand has been significantly improved in the evaluation of universal-design principles. In the future design, architecturally innovative products with inaccurate design factors can also use this process to complete the design and development of the target product, and to significantly enhance the universal-design evaluation of the product.
Cultural Hybridization in Christian China: The Art of Cloisonné at The Service of God
Authors: Parada López de Corselas Manuel , Vela-Rodrigo Alberto A.
Published: December 2021

The usual conception of traditional Chinese art tends to forget the existence of a rich cultural legacy of Christian origin that has been reflected in the manufacture of ritual objects for the convert communities and European missionaries in China. Among the most used techniques, cloisonné stands out, with important liturgical or decorative pieces treasured by missionaries and collectors, many of them in Western museums today. This work tries to make an approximation to some of those ritual objects used by the Christian Chinese communities that reflect the great influence that the Western artistic models had in the conception of art as a result of the cultural hybridization between both worlds.
Karst Collapse Risk Zonation and Evaluation in Wuhan, China Based on Analytic Hierarchy Process, Logistic Regression, and InSAR Angular Distortion Approaches
Authors: Hu Jiyuan , Motagh Mahdi , Wang Jiayao , Qin Fen , Zhang Jianchen , Wu Wenhao , Han Yakun
Published: December 2021

The current study presents a detailed assessment of risk zones related to karst collapse in Wuhan by analytical hierarchy process (AHP) and logistic regression (LR) models. The results showed that the LR model was more accurate with an area under the receiver operating characteristic (ROC) curve of 0.911 compared to 0.812 derived from the AHP model. Both models performed well in identifying high-risk zones with only a 3% discrepancy in area. However, for the medium- and low-risk classes, although the spatial distribution of risk zoning results were similar between two approaches, the spatial extent of the risk areas varied between final models. The reliability of both methods were reduced significantly by excluding the InSAR-based ground subsidence map from the analysis, with the karst collapse presence falling into the high-risk zone being reduced by approximately 14%, and karst collapse absence falling into the karst area being increased by approximately 6.5% on the training samples. To evaluate the practicality of using only results from ground subsidence maps for the risk zonation, the results of AHP and LR are compared with a weighted angular distortion (WAD) method for karst risk zoning in Wuhan. We find that the areas with relatively large subsidence horizontal gradient values within the karst belts are generally spatially consistent with high-risk class areas identified by the AHP- and LR-based approaches. However, the WAD-based approach cannot be used alone as an ideal karst collapse risk assessment model as it does not include geological and natural factors into the risk zonation.
Testing Accuracy of Land Cover Classification Algorithms in the Qilian Mountains Based on GEE Cloud Platform
Authors: Yang Yanpeng , Yang Dong , Wang Xufeng , Zhang Zhao , Nawaz Zain
Published: December 2021

The Qilian Mountains (QLM) are an important ecological barrier in western China. High-precision land cover data products are the basic data for accurately detecting and evaluating the ecological service functions of the QLM. In order to study the land cover in the QLM and performance of different remote sensing classification algorithms for land cover mapping based on the Google Earth Engine (GEE) cloud platform, the higher spatial resolution remote sensing images of Sentinel-1 and Sentinel-2; digital elevation data; and three remote sensing classification algorithms, including the support vector machine (SVM), the classification regression tree (CART), and the random forest (RF) algorithms, were used to perform supervised classification of Sentinel-2 images of the QLM. Furthermore, the results obtained from the classification process were compared and analyzed by using different remote sensing classification algorithms and feature-variable combinations. The results indicated that: (1) the accuracy of the classification results acquired by using different remote sensing classification algorithms were different, and the RF had the highest classification accuracy, followed by the CART and the SVM; (2) the different feature variable combinations had different effects on the overall accuracy (OA) of the classification results and the performance of the identification and classification of the different land cover types; and (3) compared with the existing land cover products for the QLM, the land cover maps obtained in this study had a higher spatial resolution and overall accuracy.