bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Automated Means of Content Analysis of Data from Geoinformation Networks to Study the Accessibility of Landscaping Facilities
Authors: Nizomutdinov Boris Abdullochonovich , Kazak Vladimir Andreevich , Begen Petr Nikolayevich
Published: February 2022

The article presents a method developed by the authors to assess the accessibility of urban improvement facilities for low-mobility groups of the population based on the analysis of text data from social networks and the socio-psychological well-being of city residents. The object of the study was the profiles of landscaping objects in Google Maps located in the Petrogradsky district of St. Petersburg, 25 urban landscaping objects (parks, gardens, squares) were selected. During the study, the total number of comments for each improvement object was determined, reviews were analyzed, reviews were identified that describe the impressions and experiences of elderly and low-mobility groups, and the tonality of these messages was evaluated. The analysis of the reviews showed that the comments contain information from low-mobility groups of the population describing the problems of improvement facilities, in particular accessibility. The conclusion is made about the great potential that can be extracted from the use of automated data collection from geoinformation social systems. Findings show that overlapping data from Google Maps enriches the analysis that would previously have relied on a single source.
Maisonneuve Fractures of the Ankle
Authors: Bartoníček Jan , Rammelt Stefan , Tuček Michal
Published: February 2022

» Maisonneuve fractures (MFs), originally described as subcapital (high) fibular fractures with additional injury to the anterior and interosseous tibiofibular ligaments, display a variable injury pattern, ranging from stable to highly unstable fractures.

» The high incidence of associated fractures of the posterior malleolus, the medial malleolus, and the anterolateral distal tibia (the “anterior malleolus”) as well as the variable position of the fibula in the fibular notch (FN) warrant preoperative examination via computed tomography (CT).

» The main goal of treatment is anatomic reduction of the distal fibula into the FN, which requires prior reduction of displaced posterior malleolar fractures, if present, to restore the integrity of the FN.

» Open reduction of the distal fibula into the FN and fixation with 2 transsyndesmotic screws or fixation with a screw(s) and suture-button implant, under direct vision, on the lateral aspect of the ankle joint and anterior tibiofibular alignment are preferred over closed reduction to avoid sagittal or rotational malpositioning, which is associated with an inferior outcome.

» Intra- or postoperative 3D CT visualization is essential for assessment of the accuracy of the reduction of the distal fibula into the FN.
Idiopathic Toe-Walking in Children and Adolescents
Authors: Freiman Halle D. , Mensah Curtis , Codrington Jason , Frick Steven L.
Published: February 2022

» Idiopathic toe-walking is a diagnosis of exclusion.

» The natural history of idiopathic toe-walking has not been studied in many children; we identified only 1 prospective study. Of children without equinus contractures who were toe-walking before the age of 5.5 years, 59% had spontaneous resolution of toe-walking by 5.5 years of age, and 79%, by the age of 10 years.

» Adverse consequences of toe-walking into adulthood have not been reported, but may exist, and further research is needed to define and clarify.

» If parents desire treatment to resolve their child’s toe-walking, surgical lengthening of the Achilles tendon is the treatment with the highest chance of success and lowest relapse rate, and thus far, no complications have been reported in any surgical series.
ANALYSIS OF THE QUALITY PARAMETER AND THE FATTY ACID CONTENT FROM THE FOUR OF INDONESIAN CONSUMED NUTS
Authors: Maulana Indra Topik , Deviani Tiara , Nurulfikri Alfiah
Published: February 2022

Consumption of nuts is known to have a variety of health benefits. Nutritional contents in the nuts are needed, especially in order to provide healthy food. Nuts are rich in protein, carbohydrates, fiber, fatty acids, and bioactive compounds. There are four types of beans that are commonly consumed by Indonesian people, namely soybeans [Glycine max (L.) Merr], green beans [Vigna radiata (L.) Wilezek], peas (Pisum sativum L.), and red beans (Phaseolus vulgaris L). The purposes of this study were to produce data on the content of secondary metabolites, the value of quality parameters, and data on fatty acid content in four types of nuts. A series of research phases have been conducted including phytochemical screening, analysis of quality parameters, and analysis of fatty acid content using gas chromatography-mass spectroscopic methods (GCMS). The results showed that the four types of beans contained alkaloids and essential oils, and some of them contained flavonoids, tannins, saponins, and polyphenols. Analysis of quality parameters showed that the content of polar compounds was higher than the semi-polar and non-polar compounds. The largest yield of fatty oil was produced from soybeans (3.83%) followed by peas (1.25%), green beans (0.57%), and kidney beans (0.44%). The oils from the all both contained palmitic acid, LA, and stearic acid. Only green bean and red bean oil contained omega-3, namely ALA, in the amounts respectively 20.37% and 40%. Meanwhile, soybean and peanut oil contained LA 36.71% and 35.53% respectively.
COVID-19 UNCERTAINTY AND MONETARY POLICY RESPONSES: EVIDENCE FROM EMERGING MARKET ECONOMIES
Authors: Prabheesh K.P. , Juhro Solikin M. , Harun Cicilia Anggadewi
Published: February 2022

This paper examines the effectiveness of monetary policy transmission in emerging economies during the COVID-19 outbreak. Using data from 14 emerging economies severely affected by the pandemic and the autoregressive distributed lag approach to cointegration, the study examines the effectiveness of monetary policy in affecting output, inflation, and credit. The study finds that: (1) In most economies, the monetary policy transmission to inflation is weakened due to the uncertainty created by the COVID-19 pandemic; (2) in a few economies, the transmission is found to be effective in stabilizing credit and output; and (3) the outbreak of the COVID-19 pandemic induced economic agents to follow a “cautionary” or “wait and see” approach.
Bourneville-Pringle disease (Tuberous Sclerosis Complex - TSC) with bilateral renal angiomyolipoma and an epitheloid monomorf angiomyolipoma (EM-AML) in a 43-year- old female, a case report
Authors: Mate Kinga , Márványkövi Fanni , Vrecenár László , Zóber Tamás , Buzogány István , Beöthe Tamás
Published: February 2022

Background: The Bourneville Pringle disease, also called tuberous sclerosis complex (TSC) is a rare genetic disorder with dominant autosomal inheritance. It is a rare neurocutaneous disorder, which can affect numerous internal organs, for example the kidney(s), the heart, and the lungs. The formation of multiple hamartomas is causing the multiorgan systemic involvement. Case presentation: A 43-year-old patient presents with tuberous sclerosis, an autosomal dominant inherited neurocutaneous disorder which variably affects different organs, among them the kidneys. During follow-up the abdominal computer tomography (CT) showed bilateral angiolipomatosis (AML) and a fat-poor mass with a different solid aspect on the left side. A fat-poor AML can be a challenge to diagnose. It is vital to exclude malignancy to decide on further management. A CT guided biopsy was performed. The results showed an atypical renal angiomyolipoma, a rare monomorph, epitheloid type. A genetic examination was performed, which showed a mutation of the TSC2 genes. Conclusions: The Bourneville Pringle disease is a rare genetic, neurocutaneous disease, which can affect multiple organs by the formation of hamartomas, including renal manifestation as AML. In case of radiological findings of a fat poor CT component AML it is essential to keep in mind the possibility of a rare monomorph epitheloid AML and if there is any doubt, it is crucial to exclude malignancy by using biopsy. A fat-poor AML can be a challenge to diagnose. It is vital to exclude malignancy, to take the size of the kidney AML in consideration, the high risk of potentially massive hemorrhage to decide on further management.
Low-Value Recyclable Waste Regeneration in China: High-Efficiency Automatic Sorting Method and Experimental Research
Authors: Ji Tianchen , Fang Huaiying , Zhang Rencheng , Yang Jianhong , Fan Lulu , Li Jiantao
Published: February 2022

The municipal domestic waste (MDW) generated in China is increasing year by year, but the waste that has been regenerated is very little. In order to efficiently sort low-value recyclable waste (LVRW), which is the largest recyclable part of MDW, we designed and manufactured a machine vision pneumatic sorting equipment with waste recognition accuracy higher than 92%. Furthermore, an automated sorting method combining Mechanical sorting, near-infrared (NIR) sorting and machine vision sorting was developed specifically for MDW sorting. In field applications, the entire automated production line we built divides MDW (100%) into six types (37.7%) of single material waste and three types (33%) of composite waste, which is very beneficial to the recycling of resources in the future.
Dynamics of SAR-CoV2 Viral Load Decline and Antibody Responses in COVID-19 Patients
Authors: Auewarakul Prasert , Sirihongthong Thanyaporn , Boonarkart Chompunuch , Jitobaom Kunlakanya , Phakaratsukul Supinya , Wongsawat Ekkarat , Nimitvilai Sireethorn , Suputtamongkol Yupin
Published: February 2022

This study describes changes in the viral RNA, viable virus shedding and host immune response in COVID-19 patients. Samples showed a large variation of viral load which declined rapidly in the first week and gradually afterward. Most cases with persistent positive of viral RNA (approximate 80%) did not indicate shedding of viable virus. Some cases with undetectable specific antibody (9 from 26 cases) were viral culture positive. These indicate that delaying of immune response may result in persistent shedding of viable virus. High viral load and negative neutralizing antibody may be used as markers to identify such individuals.
Is there a causal relationship between the consequences of preoperative weight control using orlistat-based intervention and the result after one-anastomosis gastric bypass? A retrospective study
Authors: Lo Hung Chieh , Hsu Shih-Chang
Published: February 2022

BackgroundControversies remain regarding the position of preoperative weight control. Orlistat, which shares a mechanism of restricting dietary fat absorption with gastrointestinal bypass procedures, has long been widely used for weight management. The aim was to assess the mutual relationship between the results of preoperative weight control with orlistat and surgical outcomes after one-anastomosis gastric bypass (OAGB).MethodsThe medical records of all consecutive patients with body mass index (BMI) ≥ 42.5 kg/m2 who underwent primary OAGB from 2014 to 2020 were retrospectively reviewed. Orlistat was routinely suggested for this subgroup and prescribed 10-14 days preceding surgery. Patients were stratified into weight reduction (Group 1) and weight gain (Group 2) groups. The variables assessed included the correlation of pre- and postoperative weight change up to 3 years postoperatively and 30-day surgical outcomes.ResultsAmong 55 patients who fulfilled the inclusion criteria and were compliant with treatment, 35 (64%) patients lost a median of 2.0 kg, in contrast to a median weight gain of 2.9 kg in Group 2. Group 1 had a significantly higher BMI (48.9 kg/m2 vs. 44.6 kg/m2; p= 0.003) at the last clinic visit and included more females (54% vs. 25%) than Group 2. There was a trend of reduced surgical duration (107 min vs. 140 min; p= 0.109), with no difference in 30-day complications. Weight loss percentages between groups were not different at 24 months.ConclusionPreoperative weight loss with orlistat reduced the operation time but did not affect weight loss at 2 years.
Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia
Authors: Ouyang Hui , Gao Xuguang , Zhang Jun
Published: February 2022

Background The underlying mechanism of muscle atrophy in sarcopenia is still not fully understood; BCAT1 isocitrate dehydrogenase-1 encodes an evolutionarily conserved cytoplasmic aminotransferase for glutamate and branched-chain amino acids (BCAAs), thus constituting a regulatory component of cytoplasmic amino and keto acid metabolism. In human gliomas carrying wild-type isocitrate dehydrogenase-1, BCAT1 promotes cell proliferation through amino acid catabolism. Hence, the goals of this study were to unravel the potential role of BCAT1 expression in muscle atrophy and to explore the mechanisms underlying this process.MethodsWe first measured BCAT1 expression by RT-qPCR and western blotting in murine and cellular models of muscle atrophy. To understand how the BCAT1-driven changes sustained muscle cell growth, we analyzed ROS levels and activation of the mTORC1/S6K1 pathway in muscle cells. Furthermore, we performed CCK8 assays and fluorescence staining to evaluate growth rate of cells and ROS levels. Finally, we verified that depletion of BCAT1 impairs the growth rate of muscle cells and increases ROS levels, indicating that muscle atrophy resulted from the downregulation of the mTORC1/S6K1 pathway. Data were analyzed by two-tailed unpaired Student’s t-test or Mann-Whitney U test for two groups to determine statistical significance. Statistical analyses were performed using GraphPad Prism version 6.0 and SPSS 16.0 software.ResultsBCAT1 expression level in skeletal muscles was lower in murine and cellular models of sarcopenia than in the control groups. BCAT1 knockdown not only suppressed the growth of muscle cells but also increased the production of ROS. Impaired cell growth and increased ROS production was rescued by co-introduction of an shRNA-resistant BCAT1 cDNA or addition of the mTORC1 stimulator MYH1485. Muscle cells with BCAT1 knockdown featured lower mTORC1 and S6K1 phosphorylation (pS6K1) than NT muscle cells. Addition of either shRNA-resistant BCAT1 cDNA or MYH1485 rescued the suppression of cell growth, increase in ROS production, and decrease in pS6K1. ConclusionsThe BCAA catabolic enzyme BCAT1 is essential for the growth of muscle cells. BCAT1 expression contributes to sustained growth of muscle cells by activating mTOR signaling and reducing ROS production.
Replacement of sodium silicate-based alkali activator by rice husk ash in geopolymer production
Authors: Chokkha Siriwan , Ayawanna Jiratchaya , Poowancum Anurat
Published: February 2022

Rice husk ash was used as an active-SiO2 source for the production of low-cost metakaolin based geopolymer. For cost reduction, active-SiO2 from husk ash was used as an alternative Na2SiO3 activator replacement. The starting materials such as metakaolin, husk ash and NaOH with SiO2/Al2O3 ratios of 1.58 - 1.95 were studied and calculated by XRF results. The fast hardening of geopolymer from husk ash occurred after curing at room temperature for 24 hrs. The strength of all samples was enhanced by increasing the amount of active-SiO2 from husk ash. The geopolymer from husk ash with SiO2/Al2O3 ratio of 1.95 showed high compressive strength with a value of 25 MPa. The production cost of geopolymer from husk ash was decreased with the value of 84.78%. Husk ash is an alternative natural active-SiO2 for replacing Na2SiO3 activator in the geopolymer manufacturing process, indicating a decrease in the cost of the process.
Interaction between 694nm red (ruby) laser photons and a static magnetic field – evidence for charge and mass of the photon
Authors: Haywood Rachel
Published: February 2022

Photons are described by particle and wave theories. It is accepted photons do not possess mass, charge nor are deflected by a magnetic field. A 2005 review concluded photon mass was mathematically feasible, but lacked experimental evidence [1]. During electron-spin-resonance experiments, hair containing melanin was 694 nm laser-irradiated. An ‘off-resonance’ at laser-firing was observed in a time-scan at constant magnetic field, whilst monitoring laser-induced radical formation [2]. It was hypothesised coherent photons interacted with the field, suggesting charge, magnetism and mass. The radical g-value was invariant in successive field-scans, although the hair melted. Melanin in the solid state in hair, does not exhibit temperature-dependent paramagnetism [3]. 2.2 – 3.6 x 1019 photons in 6 – 10 J were calculated to be absorbed, and a mean 72% ‘off resonance’ signal-drop determined from the time-scan, translates to a field-shift of 4 G or 4 x 10-4 T. If the pulse is a point charge (Nphoton .qphoton) with Nphoton the photon number and qphoton the charge per photon, then from the Biot-Savart equation qphoton can be calculated from 0.0004.(Nphoton x 29.98/r2)-1, where r is 1 m, and is 3.6 – 6.1 x 10-25 coulombs. The calculated collision photon : electron charge (q/e) approaches 3 x 10-6. If qphoton is extrapolated for photons moving in air/space by a ‘dilution factor’ of 106 then q/e would be 10-13 and comparable to laboratory-based measurements of 10-14-10-17. The observation and calculations suggest photons are charged; discrepancies in the measured values reflect differences in photon speed at the point of measurement.[1] Liang-Cheng Tu, Jun Luo and George T Gillies. The Mass of the Photon. Rep. Prog Phys 2005: 68; 77-130.[2] Rachel M. Haywood and Claire Linge. Differences in Production of Melanin Radicals by 694 nm Ruby Laser and UVA Radiation. Lasers Surg Medicine 2004: 35; 77-83.[3] Shiu-Shin Chio, James S. Hyde and Roger C. Sealy. Temperature-Dependent Paramagnetism in Melanin Polymers. Arch Biochem Biophys 1980: 199; 133-139.
Changes of cardiac magnetic resonance T1 and ECV values in healthy adults of different sex and age
Authors: Huang Shumei , Zhang Meng , Yu Kanghui , Li Chunlong , Lan Zhihong , Feng Ying , Lin Shiqi , Ma Xiaofen , Wu Yunfan , Jiang Guihua
Published: February 2022

[Background] The correlation between T1 and ECV value and myocardial fibrosis has been confirmed, and many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and sex.[Methods] We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. [Results] Under 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only sex (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while sex (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. [Conclusions] T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.
Standardized Reporting and Quantification of Whole-Body MRI findings in Children with Chronic Non-Bacterial Osteomyelitis Treated with Pamidronate
Authors: Andreasen Caroline Marie , Klicman Rikke Fuglsang , Herlin Troels , Hauge Ellen Margrethe , Jurik Anne Grethe
Published: February 2022

ObjectivesTo test a modified radiological index for non-bacterial osteitis (mRINBO) used for standardized reporting and quantification of whole-body MRI (WBMRI) findings in children with chronic non-bacterial osteomyelitis (CNO) receiving pamidronate therapy.MethodsWBMRI was assessed in 18 children with CNO at baseline and after receiving pamidronate therapy for one year. Parameters of interest were: number and anatomic site of radiologically active bone lesions (RAL), size of RAL, extramedullary affection, spinal involvement and changes in mRINBO, which includes both the number and maximal size of RAL (RALmax) in addition to extramedullary and chronic changes. ResultsAt the time of diagnosis, the mean age of the children was 9.8 (sd, 8.7-10.9) years and 11/18 were females. The number of RALs per patient decreased from median [interquartile range] 4.5 [3-8] to 3 [2-5] RALs per patient (p=0.02) and extramedullary inflammatory changes regressed. Sixty-one percent of all RALs occurring at baseline resolved and three children became without active inflammatory lesions by WBMRI. However, the median size of RALs did not change when taking new lesions occurring in 7/18 children into account, but RALmax decreased significantly from 39 [29-45] mm at baseline to 28 [20-40] mm (p<0.01) at year-one with a concomitant decrease of mRINBO from a median of 5 [4-7] to 4 [3-5] (p=0.05).ConclusionsmRINBO decreased during pamidronate therapy and mRINBO may be a potential scoring method to quantify changes in radiological disease activity in children with CNO. Further studies are needed to test feasibility and validity of mRINBO.
Promoting health and social equity through family navigation to prevention and early intervention services: a proof of concept study
Authors: Waid Jeffrey , Tomfohrde Olivia , Kutzler Courtney
Published: February 2022

Background. Health and social inequality are associated with multiple adverse childhood experiences including poverty, mental illness, substance abuse, and child maltreatment. While effective interventions currently exist for many health and social problems, large segments of the population experience barriers accessing needed services. In alignment with broader public health efforts to reduce health and social inequality in one state in the U.S.A., the current study describes the development and formative evaluation of a brief, low cost, portable model of prevention-oriented family service navigation called Navigate Your Way. Methods. Caregivers of children experiencing significant unmet health or social service needs were recruited to the study. Participants completed an initial and closing telephone interview which included measures of past and current family health and social service utilization, service barriers, parenting stress, and child internalizing/externalizing behaviors. Between interviews participants created a family service plan and received 10 weeks of telephone and web-mediated family navigation, at which time process and fidelity of implementation data were collected. Frequency and descriptive statistics are provided for participant demographic characteristics, service barriers, intervention engagement, and primary and secondary study outcomes. Paired samples t-tests examined changes in study outcomes between initial and closing telephone interviews. Results. Thirty two caregivers enrolled, twenty-nine completed the study. The age range was 20-59 (M=39.5, SD=10.0). The majority identified as female (96.9%, n=31), racial/ethnic minority (56.2%, n=18), and reported an average 10 barriers to care (M=10.4, SD=4.1). The most frequently reported service needs were mental health care (n=26), housing (n=11), food security (n=8), and health insurance (n=8). The mean duration of intervention delivery was 83 days (M=82.7, SD=9.0, range=74-105). Most participants (82.8%, n=24) were connected to one or more health or social services. Caregivers reported significant improvements to youth internalizing behaviors (M=-1.0, SD=2.5, t(26)=2.1, d=2.5, p=.05) and high levels of overall satisfaction with the navigation approach. Conclusion. Telephone and web-mediated service navigation is a feasible and practical approach to supporting families in rapidly connecting to health and social care. Future research investigating the efficacy and implementation of Navigate Your Way in routine settings is indicated.
The Effect of Crystalloid Co-Loading on Circulatory Stability During General Anaesthesia Induction in ASA II/III Patients for Major Abdominal Surgery: A Randomized Controlled Trial
Authors: Kos Darjan , Kamenik Mirt , Dinevski Dejan
Published: February 2022

BackgroundWe studied the effect of crystalloid co-loading with simultaneous infusion of vasopressor phenylephrine on circulatory stability during general anaesthesia induction with propofol in ASA II/III patients. We analysed the postinduction phase because circulatory instability is most prevalent in this period and more prominent in multimorbid patients. Prevention rather than treatment might be a better strategy to avoid complications associated with even short periods of instability.Methods46 ASA II/III patients were randomly assigned to two treatment groups. During the induction, the control group received an infusion of phenylephrine only and the test group received the same phenylephrine regimen and also a crystalloid co-load. Cardiac index (CI), mean arterial pressure (MAP), stroke volume index (SVI), systemic vascular resistance index (SVRI), stroke volume variation (SVV) and heart rate (HR) were recorded for 18 minutes and the dynamics of change between groups analysed.ResultsCI decreased in both groups after the induction but less in the test group, almost reaching statistical significance (p=0,052). MAP also decreased more in the control group; however, not reaching statistical significance. HR decreased in both groups, significantly more in the test group (p=0,041). SVRI almost identically increased in both groups. SVI decreased in the control group, whereas it significantly increased after initial decrease in the test group (p=0,006). SVV slowly decreased under 10% in the test group and increased over 10% in the control group.ConclusionsOur results show that phenylephrine combined with crystalloid co-loading enables better circulatory stability than phenylephrine alone.Trial registrationThe study was registered on 15th of March 2017 at ISRCTN registry: http://www.isrctn.com/ISRCTN46293288 and was retrospectively registered.Clinical trial number is ISRCTN46293288.
Clinical features and immunophenotypes of double-hit diffuse large B-cell lymphoma
Authors: Wu Cheng-Han , Gau Jyh-Pyng , Teng Chieh-Lin Jerry , Shih Yu-Hsuan , Su Yu-Chen , Wang Ren-Ching , Chen Tsung-Chih
Published: February 2022

Double-hit (DH) genetics induces a reduction in the complete remission (CR) and, consequently, in poor overall survival (OS) in diffuse large B-cell lymphoma (DLBCL) patients. Unfortunately, DH identification is time-consuming. Here, we retrospectively reviewed 92 newly diagnosed DLBCL patients and stratified them into the DH (n = 14) and non-DH groups (n = 78). The clinical features and treatment outcomes were compared between the two groups, and clinical parameters were employed to predict DH genetics. The results revealed that the DH group had a higher percentage of bulky disease than the non-DH group (64.3% vs. 28.2%; p = 0.013). More patients in the DH group tested positive for double expresser (DE) (50.0% vs. 21.8%; p = 0.044). Conversely, the CR rates in these groups were not significantly different (50.0% vs. 60.3%; p = 0.672). The three-year OS rates of patients with and without DH were 28.6% and 49.7%, respectively (p = 0.008). Importantly, DH genetics (HR: 6.19; 95% CI: 1.59–24.07; p = 0.009), advance stage (HR: 9.24; 95% CI: 1.34–63.63; p = 0.024), and a high uric acid level (HR: 1.24; 95% CI: 1.00–1.54; p = 0.046) were correlated with a high mortality rate. Furthermore, by combining DE and the bulky disease, a specificity of 89.7% for DH prediction was achieved. In summary, DH genetics, not DE immunopositivity, is a poor prognostic factor for newly diagnosed DLBCL. A combination of bulky disease and a positive DE immunophenotype could facilitate DH genetics prediction in newly diagnosed DLBCL patients.
Simplified Model for Pre-Code RC Column exposed to Fire Followed by Earthquake
Authors: Ioannou Ioanna , Rossetto Tiziana , Rush David , Melo José
Published: February 2022

The behaviour of pre-code RC columns in sequence of fire and earthquake is not well understood and can be critical in case of buildings which experienced fire and are either unrepaired or poorly repaired when exposed to an earthquake. This study proposes a framework on how to construct a simplified model to assess the post-fire cyclic behaviour of such columns. Emphasis is given to the development of simplified material models which can be used to describe the performance of the confined concrete, as its post-fire behaviour is not well studied. The model’s performance is validated against the experimental results of a square, non-seismically designed RC column. Three scenarios are considered. The reference scenario, where the column is exposed only to cyclic loading. In the other two, the column is firstly exposed to an ISO-834 time-temperature curves in a furnace of 30min and 90min duration and after it cooled down, it is then exposed to cyclic loading. The results showed that simplified material models can be used to capture the post-fire cyclic behaviour of an RC column, built without seismic design. It was also found that the confined model adopted played an important role after the peak strength is reached.
Salvage Surgeries for Splanchnic Artery Aneurysms after Failed Endovascular Therapies: Cases Series
Authors: Lin Yi-Chun , Liao Tzu-Chi , Jeng Long-Bin , Yang Horng-Ren , Hsu Chung-Ho , Lin Wei-Ching , Wu Ching-Feng , Yeh Chun-Chieh
Published: February 2022

IntroductionEndovascular therapies are the first-line treatment for splanchnic aneurysms. However, after failed endovascular therapies or giant aneurysms with mass effects, appropriate management for splanchnic aneurysms remained inconclusive.MethodA retrospective review was performed for consecutive patients (from 2019 to 2021) who underwent salvage surgeries following failed endovascular therapies for splanchnic artery aneurysms. Salvage operations included total aneurysmectomy with end-to-end vascular reconstruction and partial aneurysmectomy with directly closing bleeders from the intraluminal space of the aneurysms.ResultFour patients received salvage surgeries for three false aneurysms of the celiac or superior mesenteric arteries and a true aneurysm of the common hepatic artery. The causes of failed endovascular therapies included coil migration, insufficient space for safely deploying the endovascular stent or persistent mass effect from the thrombosed giant aneurysm. Mean hospital stay was five days (range, 3-7 days), with 0% of morbidity and mortality rate and 100% of symptoms improvement. During the follow-up period (mean, 8.75 months; range, 4-15 months), one patient suffered a small residual asymptomatic celiac artery aneurysm (8 mm in diameter) and was treated conservatively due to underlying liver cirrhosis.ConclusionSurgical management is a feasible, effective, and safe alternative for splanchnic aneurysms undergoing failed endovascular therapies.
Stat-3 Signaling Role in an Experimental Model of Nephropathy Induced by Doxorubicin.
Authors: Santos Thabata , Pereira Gabriel , Perez Ricardo , Coutinho Anna , Pereira Halisson , Silva Debora , Lima Marcelo , Dias Fernando , Almeida Danilo , Pereira Rafael
Published: February 2022

Focal Segmental Glomerulosclerosis (FSGS) is one of the most frequent glomerulopathies, and is considered a public health problem worldwide. FSGS is characterized by glomerular loss mainly due to inflammation and collagen fibers deposition. STAT-3 is a transcription factor associated with cell differentiation, migration and proliferation. Its activation occurs in response to several growth factors and cytokines. In renal cells, STAT-3 has been related with disease progression. Considering this perspective, the present study evaluated the involvement of STAT-3 in an experimental model of FSGS induced by Doxorubicin (DOX). First, we described a novel FSGS model in Swiss mice that after DOX administration showed typical signs of kidney dysfunction like higher proteinuria. Since there were no studies of ADM nephropathy model in heterogeneous mice, we were the first to evaluate the model in this lineage. Control animals treated with STAT-3 inhibitor (STATTIC) presented lower levels of albumin/creatinine ratio, glycosuria e proteinuria while DOX-injected mice showed higher levels. After analyzing some molecules involved in the STAT-3 signaling pathway, it was observed that STAT-3 blockade decreased levels of STAT-3, IL-6 and IL-6R, which remained elevated in DOX-administrated mice. Moreover, we detected that SOCS-3 (a regulator of STAT family) was up-regulated only in STATTIC-treated mice. Finally, histopathological analyzes showed that DOX-treated group had a significant increase in a tubulointerstitial fibrosis and tubular necrosis, which were not identified in both control and STATTIC groups. Thus, our results indicate that STAT-3 can have an important role in experimental FSGS induced by DOX and further studies are encouraged.
Association of Serum Uric Acid and Blood Pressure: A Cross-Sectional Study in A Working Population in China
Authors: Qian Hang , Mei Aihua , Xu Hao , Chen Jishun , Zhou Xintao , Li Yunpeng , Min Xinwen , Yang Handong , Li Xiulou , Yang Jingning , Zhong Jixin , Jiang Xueqiang , Li Dongfeng , Chen Jun
Published: February 2022

Objective: The aim of this study was to evaluate the independent relationship between Serum uric acid (SUA) and blood pressure. Methods: A cross-sectional study was conducted based on a sample of 6035 employees (3605 males and 2430 females). Multivariable regression analysis was performed to identify the association between risk factors for metabolic disorders and hypertension. Results: The SUA levels were closely and independently related to hypertension even after adjusting for age, sex, lipids and glucose. Conclusions: We verified that uric acid was associated with hypertension independent of other metabolic risk factors and that the presence of other risk factors with uric acid had an additive effect on blood pressure.
Insensitive cation effect on single-atom Ni catalyst allows selective electrochemical conversion of captured CO2 in universal media
Authors: Kim Jae Hyung , Jang Hyunsung , Choi Woong , Yun Hyewon , Lee Eun Chong , Kim Dongjin , Kim Ji Won , Lee Si Young , Hwang Yun Jeong
Published: February 2022

The direct electroconversion of captured CO2 is attracting attention as an alternative to the current energy-demanding CO2 separation processes. In conventional capturing media, the reaction inevitably takes place in the presence of bulky ammonium, leading to steric hindrance and low CO selectivity. Here, for the first time, we present a single atom Ni catalyst (Ni–N/C) exhibits superior activity for the electroconversion of captured CO2, without the need for additives. In a CO2-captured monoethanolamine-based electrolyte, Ni–N/C achieves a notably high CO selectivity of 64.9% at −50 mA cm−2 integrated with a membrane electrode assembly. We also propose that Ni–N/C demonstrates weak cation sensitivity to the CO2 reduction reaction, maintaining high CO production activity in various capturing solutions, while Ag shows a gradual decrease depending on the bulkiness of the amine. These trends provide insights into selective catalyst design for the electroconversion of captured CO2 in universal media.
Prognostic Implications of the Predominant Histologic Subtype in Stage I Lung Adenocarcinoma: Lack of Association with Overall Survival Based on Multi-Aspect Survival Analyses
Authors: Lee Jong Hyuk , Kim Hyungjin , Park Chang Min , Jeon Yoon Kyung , Chung Doo Hyun , Kim Young Tae , Goo Jin Mo
Published: February 2022

We aimed to investigate the prognostic role of the predominant histologic subtype classification of lung adenocarcinoma in the era of the eighth-edition staging system. A total of 587 patients with stage I adenocarcinomas (lepidic, n=46; acinar/papillary, n=484; solid/micropapillary, n=57) were assessed. The prognostic value of this subtype classification for overall survival (OS) was investigated with three multivariable analyses adjusted for the eighth-edition clinical T category and radiologic nodule type: the adjusted log-rank test, multivariable Cox hazard regression, and multivariable mixture cure model to evaluate long-term and short-term prognostic associations separately. In the adjusted log-rank test for pairwise comparisons, no evidence was found for differences in OS among the subtype classifications (p>.05). The histologic subtype was not an independent prognostic factor in either the Cox regression analysis (hazard ratio [HR] of acinar/papillary subtypes: 3.03; 95% confidence intertval [CI]: 0.4-22.59; p=0.28; HR of solid/micropapillary subtypes: 2.78; 95% CI: 0.34-22.37; p=.34) or the mixture cure model (cure probability model; odds ratio: 1.06 [95% CI: 0.38-2.95; p=.91]; failure time distribution model; HR: 0.94 [95% CI: 0.36-2.44; p=.89]). The prognostic implication of the predominant histologic subtype classification is not clear for stage I lung adenocarcinoma in the eighth-edition staging system.
Complications and Owner Satisfaction Associated with Limb Amputation in Cats: 59 cases (2007-2017)
Authors: Wagner John R. , DeSandre-Robinson Dana M. , Moore George E. , Loughin Catherine A. , Simons Micha C.
Published: February 2022

Background:Limb amputation may be recommended in domestic cats following a severe injury or disease. The purpose of the study was to report the signalment, the complications, recovery outcome, owner satisfaction and expectations of domestic cats following limb amputation. Results:Medical records of 3 specialty hospitals were reviewed for cats that received a single limb amputation in a 10 year period (2007-2017). These cat owners were contacted, and 59 owners completed surveys, comprising the study population. The most common reasons for limb amputation were neoplasia (54.2%, 32/59), traumatic injury (40.7%, 24/59), bone or joint infection (3.4%, 2/59), and thromboembolism (1.7%, 1/59). Thirty-four cats (57.6%) had postoperative complications. Of the fifty-nine surveys, 52.5% reported minor complications and 5.1% reported major complications. There were no differences in postoperative complication rates for thoracic versus pelvic limb amputations. All owners reported either excellent (77.9%, 46/59), good (20.3% 12/59), or fair (1.7%, 1/59) satisfaction with the procedure. Based on their previous experiences, 84.7 % (50/59) of owners would elect limb amputation if medically warranted for another pet. The remaining 15.3% of owners which would not elect limb amputation again had experienced death of their pet with a median survival time of 183 days. Conclusion:Owners reported a positive satisfaction when considering complications, recovery outcome, and expectations. This study can be used by veterinarians to guide cat owners in the decision making process of limb amputation.
Construction and validation of an m6A RNA methylation regulator prognostic model for early-stage clear cell renal cell carcinoma
Authors: Zhang Yushi , Wang Zhan , Zhang Mingxin , Seery Samuel , Zheng Guoyang , Wang Wenda , Zhao Yang , Wang Xu
Published: February 2022

Background: N6-methyladenosine (m6A) is the most common type of RNA methylation and is thought to participate in various biological and pathological processes, specifically in the regulation of tumorigenesis and metastasis. However, the exact prognostic role of m6A methylation regulators in early-stage clear cell renal cell carcinoma (ccRCC) is currently unknown.Purposes: To construct a prognostic model consisting of m6A RNA methylation regulators in early stage ccRCC and assess the reliability of the signature by proteomics. Additionally, we also explored the relationship between the prognostic model and tumor infiltrating immune cells within the tumor microenvironment.Materials and methods: Gene mutation and RNA sequencing data of 19 m6A methylation regulators for early-stage ccRCC patients were extracted from The Cancer Genome Atlas (TCGA) database with the corresponding clinical information. Univariate and multivariate Cox regression analysis were applied to construct a prognostic model and the proteomic data was used to validate the result. The correlations with the prognostic model and tumor infiltrating immune cells were assessed using Spearman rank correlation analysis. Results: 192 early stage ccRCC gene mutation data as well as 261 RNA sequencing data with relative clinical data were extracted from the TCGA. The overall mutation frequency of the 19 m6A RNA methylation regulators was relatively low with 4.69%. The transcriptome data showed that 11 genes were differentially expressed between cancer tissues and relatively normal tissues. Survival analysis highlighted four specific genes as having a significant influence on overall survival. An established model with four genes demonstrated the best predictability for early-stage ccRCC. After integrating clinical characteristics into the multivariate analysis, the model remained effective at predicting ccRCC prognosis. Spearman rank analysis suggested several tumor infiltrating immune cells like dendric cells, CD4+ cells, CD8+ T cells and macrophages were significantly correlated with the model. Proteomic data analysis showed that all the genes used to construct the model were differentially expressed in paired ccRCC tissues. Conclusion: A novel m6A methylation regulators-based prognostic signature was established and validated using a proteomic approach. In addition, the model was significantly correlated with multiple infiltrating immune cells in tumor microenvironment.
Individual and food environment determinants of Mediterranean diet adherence among Lebanese adults: a cross-sectional study
Authors: Khoury Veronique El , Malakieh Roubina , Boumosleh Jocelyne Matar , Obeid Cecile , Jaalouk Doris
Published: February 2022

Background: Many studies revealed positive health impacts of the Mediterranean diet (MD) especially on metabolic disorders. Conversely, information about determinants of adherence to the MD are limited. This study aims to examine the individual and environmental determinants of MD adherence among adults in Lebanon. Methods: A cross-sectional study was carried out during July 2021 among a convenient sample of 326 Lebanese adults. Data from participants were collected via an online survey developed by study researchers, that is composed of 3 well-structured questionnaires: a) background questionnaire; b) Perceived Nutrition Environment Measures Survey in the Mediterranean Context (NEMS-P-MED), and c) 14-item Mediterranean Diet Adherence Screener (14-MEDAS). Results: Mean MD score in the total sample was 7.59±2.22, reflecting moderate-to-fair MD adherence. Older age and having a regular routine of physical activity emerged as significant independent determinants of better MD adherence. Equally, availability of whole wheat pasta, rice or flour and fish at home and perceived importance of availability of easy to cook foods at food stores showed significant positive association, while healthy food availability, and in- store characteristics had no association with MD adherence score. Conclusion: Future public health interventions aiming at promoting MD adherence among young adults in Lebanon shall take account of availability of healthy food at home alongside individual factors such as meal preparation skills and regular physical activity.
Serum RANKL, OPG and Vitamin D in children with systemic lupus erythematosus
Authors: Hao Sheng , Zhang Jing , Huang Bingxue , Feng Dan , Niu Xiaoling , Huang Wen-Yan
Published: February 2022

Indroduction: SLE is an autoimmune multisystem disease. Glucocorticoid is an irreplaceable medication for SLE. Glucocorticoid and inflammation impact bone remodeling by OPG/RANKL/RANK signal system, which could lead to osteoporosis. Our aim is to clarify the expression of RANKL/OPG in children with SLE, and to preliminarily explore the changes of bone metabolism related indexes in children with SLE. Methods: Serum RANKL and OPG of 40 children with SLE and healthy children were detected by ELISA, while 25(OH)VitD3 was detected routinely. Clinical data of children with SLE were recorded, including gender, age, height, weight, BMI, duration of the disease, accumulated dose of glucocorticoid, and correlation analysis was conducted with RANKL, OPG and 25(OH)VitD3. Results: Serum RANKL concentration in SLE group was significantly higher than health group (9.82±7.20 vs. 6.80±4.35 pg/ml, P<0.05), and the concentrations of OPG and 25(OH)VitD3 in serum were significantly lower than health group (156.34±57.33 vs. 189.16±68.70 pg/ml and 43.66±31.27 vs. 59.04±21.56 mmol/L, P<0.05). Serum RANKL in children with SLE was positively correlated with the duration of SLE, accumulated dose of GC(r=0.593, 0.727, P<0.05). And it was negatively correlated with serum OPG and 25(OH)VitD3 (r=-0.601, -0.469, P<0.05). In addition, serum OPG and 25(OH)VitD3 concentrations were inversely correlated with accumulated dose of GC (r=-0.66, -0.508, P<0.05). Conclusion: Low levels of vitamin D3 and bone metabolic abnormalities were found in children with SLE under the condition of disease remission, while serum RANKL expression was elevated, OPG expression was reduced. These changes associated with the duration of SLE, accumulated dose of GC. In the case of exclusion of disease activity, GC and other factors may be involved in the occurrence and development of abnormal bone metabolism through RANKL/OPG.
The training effects of a continuing education program on nurses’ knowledge and attitudes to palliative care: a cross sectional study
Authors: Chen Xian , Zhang Yuxi , Arber Anne , Huo Xiaorong , Liu Jin , Sun Cuihua , Yuan Ling , Wang Xuemei , Wang Dan , Wu Jinfeng , Du Junjie
Published: February 2022

Background: Most nurses in China have not been trained to take care of end-of-life patients appropriately due to lack of educational resources and insufficient training. A palliative care program was launched by the Jiangsu Nursing Association (JNA training program) and to identify gaps in palliative care training. The main aims of this study were to evaluate the training effects of the JNA training program on nurses’ knowledge and attitudes to palliative care. Methods: A cross-sectional study was conducted with 10 048 registered nurses in all regions of Jiangsu. All participants completed an online questionnaire using the Chinese version of The Palliative Care Quiz for Nursing (PCQN-C) and the Frommelt Attitude Toward Care of the Dying scale (FATCOD-B-C). A propensity score matched analysis was performed between the nurses who had attended the JNA training program and whose who hadn’t.Results: The average score of PCQN-C among all nurses was 8.79, while the mean score of the FATCOD-B-C was 103.62. Those participants who attended the JNA training program had significantly better scores than those who did not. Propensity score matching analysis showed that the palliative care training program failed to improve nurses’ knowledge in psychosocial and spiritual care or their attitudes towards the necessity of family support although there was positive impact on other aspects of palliative care.Conclusions: Knowledge of palliative care among Chinese nurses remains low. Training programs may improve general knowledge and attitudes to palliative care. However, important aspects of knowledge such as communication skills, family support, and psychosocial aspects of care, are missing. These gaps should be filled in future palliative care training programs targeting nurses with oriental culture background.