bluuebunny/crossref_metadata_2025 huggingface dataset:
The Neonatal QRS Complex and Its Association with Left Ventricular Mass
Authors: Molin Julie , Hartmann Joachim , Pærregaard Maria Munk , Thygesen Caroline Boye , Sillesen Anne-Sophie , Raja Anna Axelsson , Vøgg Ruth Ottilia Birgitta , Iversen Kasper Karmark , Bundgaard Henning , Christensen Alex Hørby
Published: December 2023

To evaluate QRS complex features during the first month of life and the association with echocardiographic measurements of left ventricular mass in neonates. Prospective cohort study of neonates with electrocardiography (ECG) and echocardiography performed during the first month of life. Left ventricular mass index (LVMI) was determined by echocardiography and the correlation with electrocardiographic markers of LVMI outliers (≥ 98th percentile) were analyzed. We included 17,450 neonates (52% boys; median age at examination 11 days) and found an increase in median QRS duration and LVMI during the first month of life (54 vs. 56 ms and 24.7 vs. 28.6 g/m2 at days 0–4 and 25–30, respectively; both p < 0.001). All investigated ECG features (QRS duration, QRS area in V1/V6, maximum amplitudes of S-V1/R-V6, and the Sokolow–Lyon voltage product) showed no to low correlation with LVMI, resulting in low sensitivities (0–9.0%), but high specificities (97.2–98.1%), and area under the curve values close to the identity line (0.49–0.61) for identifying LVMI outliers. Adjustment of outlier definition for LVMI and threshold for QRS features had no significant effect on sensitivity. We present reference values for QRS complex features and their association with LVMI in neonates from a large, unselected, population-based cohort. The QRS complex gradually evolved during the first month of life but had a low correlation with LVMI. Our results indicate a poor diagnostic value of using ECG features to identify LVMI outliers in neonates.

Trial Registry Copenhagen Baby Heart, NCT02753348, https://clinicaltri-als.gov/ct2/show/NCT02753348?cond=Copenhagen+Baby+Heart&draw=2&rank=1, deidentified individual participant data will not be made available.
Prediction of disease severity in COPD: a deep learning approach for anomaly-based quantitative assessment of chest CT
Authors: Almeida Silvia D. , Norajitra Tobias , Lüth Carsten T. , Wald Tassilo , Weru Vivienn , Nolden Marco , Jäger Paul F. , von Stackelberg Oyunbileg , Heußel Claus Peter , Weinheimer Oliver , Biederer Jürgen , Kauczor Hans-Ulrich , Maier-Hein Klaus
Published: December 2023

Objectives

To quantify regional manifestations related to COPD as anomalies from a modeled distribution of normal-appearing lung on chest CT using a deep learning (DL) approach, and to assess its potential to predict disease severity.

Materials and methods

Paired inspiratory/expiratory CT and clinical data from COPDGene and COSYCONET cohort studies were included. COPDGene data served as training/validation/test data sets (N = 3144/786/1310) and COSYCONET as external test set (N = 446). To differentiate low-risk (healthy/minimal disease, [GOLD 0]) from COPD patients (GOLD 1–4), the self-supervised DL model learned semantic information from 50 × 50 × 50 voxel samples from segmented intact lungs. An anomaly detection approach was trained to quantify lung abnormalities related to COPD, as regional deviations. Four supervised DL models were run for comparison. The clinical and radiological predictive power of the proposed anomaly score was assessed using linear mixed effects models (LMM).

Results

The proposed approach achieved an area under the curve of 84.3 ± 0.3 (p < 0.001) for COPDGene and 76.3 ± 0.6 (p < 0.001) for COSYCONET, outperforming supervised models even when including only inspiratory CT. Anomaly scores significantly improved fitting of LMM for predicting lung function, health status, and quantitative CT features (emphysema/air trapping; p < 0.001). Higher anomaly scores were significantly associated with exacerbations for both cohorts (p < 0.001) and greater dyspnea scores for COPDGene (p < 0.001).

Conclusion

Quantifying heterogeneous COPD manifestations as anomaly offers advantages over supervised methods and was found to be predictive for lung function impairment and morphology deterioration.

Clinical relevance statement

Using deep learning, lung manifestations of COPD can be identified as deviations from normal-appearing chest CT and attributed an anomaly score which is consistent with decreased pulmonary function, emphysema, and air trapping.

Key Points

• A self-supervised DL anomaly detection method discriminated low-risk individuals and COPD subjects, outperforming classic DL methods on two datasets (COPDGene AUC = 84.3%, COSYCONET AUC = 76.3%).

• Our contrastive task exhibits robust performance even without the inclusion of expiratory images, while voxel-based methods demonstrate significant performance enhancement when incorporating expiratory images, in the COPDGene dataset.

• Anomaly scores improved the fitting of linear mixed effects models in predicting clinical parameters and imaging alterations (p < 0.001) and were directly associated with clinical outcomes (p < 0.001).
Interdecadal change of Tibetan Plateau vortices during the past 4 decades and its possible mechanism
Authors: Lin Zhiqiang , Guo Weidong , Ge Jun , Yao Xiuping , Su Dongsheng
Published: December 2023

The Tibetan Plateau vortices (TPVs) are mesoscale weather systems active at the near-surface of the Tibetan Plateau (TP), which are one of the major precipitation-producing systems over the TP and its surrounding areas. TPVs mainly occur in the warm season from May to September. In this paper, we investigated the interdecadal change of TPVs in the warm seasons of 1979–2020 with the six widely used reanalysis datasets. A significant change of the TPVs frequency appears around the mid-1990s, associated with less TPVs during 1979–1995 and more TPVs during 1996–2020, which is constant among the multiple reanalysis datasets. The abrupt change of TPVs is caused by a transition of the Atlantic Multi-decadal Oscillation (AMO) from a cold phase to a warm phase in the mid-1990s. The shift of AMO leads to a silk-road pattern-like wave train and a spatially asymmetric change of tropospheric temperature. It modifies the intensity of the subtropical westerly jet and the TP heating, leading to the interdecadal change of TPV activities.
Relationships between diet and gut microbiome in an Italian and Dutch cohort: does the dietary protein to fiber ratio play a role?
Authors: Tagliamonte Silvia , Puhlmann Marie-Luise , De Filippis Francesca , Guerville Mathilde , Ercolini Danilo , Vitaglione Paola
Published: December 2023

Purpose

To investigate the relationships between the habitual diet, the protein to fiber ratio (P/F), and the gut microbiome in one Italian and one Dutch cohort of healthy subjects consuming an omnivore diet.

Methods

The Italian cohort included 19 males (M_IT, BMI 25.2 ± 0.72 kg/m2, age 25.4 ± 0.96 years) and 20 females (F_IT, BMI 23.9 ± 0.81 kg/m2, age 23.8 ± 0.54 years); the Dutch cohort included 30 females (F_NL, BMI: 23.9 ± 0.81 kg/m2, age: 23.8 ± 0.54 years). Individual diets were recorded through Food Frequency Questionnaires and analyzed to assess the nutrient composition. Gut microbiome was assessed in fecal samples.

Results

M_IT consumed higher levels of proteins than F_NL and F_IT, whereas dietary fiber intake did not differ among groups. Data showed that consumption of plant protein to animal protein (PP/AP) and PP to total proteins ratio can determine a differentiation of F_NL more than the absolute amount of dietary fiber. Conversely, the protein to fiber (P/F) and AP to total proteins better characterized M_IT. M_IT harbored the highest abundance of proteolytic microorganisms and the lowest microbial gene richness. Conversely, F_NL had more fiber-degrading microorganisms like Bacteroides thetaiotaomicron, Bacteroides xylanisolvens, Roseburia sp., Coprococcus eutactus and Parabacteroides along with the highest number of genes encoding carbohydrate-active enzymes and gene richness. It was predicted that by each unit decrease in the P/F a 3% increase in gene richness occurred.

Conclusion

Study findings suggested that dietary P/F, rather than the absolute amount of dietary fiber, could contribute to the shaping of the microbiome towards a more proteolytic or fiber-degrading gut ecosystem.

ClinicalTrials.gov Identifier NCT04205045—01-10-2018, retrospectively registered.

Dutch Trial Register NTR7531—05-10-2018.
Comparison of two swept-source optical coherence tomography devices, a Scheimpflug camera system and a ray-tracing aberrometer in the measurement of corneal power in patients with cataract
Authors: Ma Shan , Gao Rongyu , Sun Jing , Yang Jun , Wen Kai , Chen Xiteng , Zhao Fangyu , Xu Xinyan , Tian Fang
Published: December 2023

Purpose

To assess the differences and similarities in the corneal curvature obtained by two swept-source optical coherence tomography (SS-OCT) devices, Scheimpflug imaging system and one ray tracing aberrometer in patients with cataracts. Moreover, this study aimed to compare the differences in posterior corneal (PK), total corneal (TK) and true net power (TNP) measurements among the IOLMaster 700, CASIA2, and Pentacam.

Methods

A total of 200 eyes of 200 patients (116 female, 58%) were enrolled in this study, with a mean age of 65.9 ± 9.5 years. The flattest (Kf), steepest (Ks), and mean cornal powers (Km), J0, and J45 were obtained using two SS-OCT-based biometric devices, one rotating camera system and one ray-tracing aberrometer. The PK, TK and TNP values were also measured using these devices. To evaluate the differences and similarities between the devicves, the Friedman test, Pearson correlation coefficient (r), intraclass coefficient correlation (ICC) and Bland‒Altman plots with 95% limits of agreement (LoA) were used, and boxplots and stacked histograms were generated to describe the distributions of the data.

Results

There were no significant differences between the IOLMaster 700 and Pentacam for any of the keratometry values. Additionally, there were no significant differences between the IOLMaster 700 and iTrace in evaluating J0 and J45. Bland‒Altman plots revealed relatively wide LoA widths, almost larger than 1 diopter for the keratometry values and almost larger than 0.5 diopter for J0 and J45 values among the four devices. In terms of PK and TK values, significant differences and low ICCs were found among the three devices.

Conclusions

Although strong correlations and good agreement were found among the IOLMaster700, CASIA2, Pentacam and iTrace for Kf, Ks, Km and J0, J45, it seems that the measurements should not be used interchangeably because of the wide LoA widths and the presence of significant differences among the devices. Similarly, due to significant differences and low ICCs, the PK, TK and TNP values obtained by IOLMaster 700, CASIA2, and Pentacam should not be used interchangeably.
Prospective analysis of the attendance behaviour of the participants of a facilitated support group for patients after allogeneic hematopoietic cell transplantation
Authors: Geeck Karsten , Kreil Sebastian , Hausmann Michaela , Hofmann Wolf-Karsten , Heidenreich Daniela , Klein Stefan A.
Published: December 2023

Purpose

Support groups might help survivors of allogeneic hematopoietic cell transplantations (HCT) to cope with medical, psychological, and social challenges. The aim of this project was (1) to establish a facilitated post-HCT support group and (2) to assess the participation behaviour.

Methods

From 11/2013 until 7/2017, all adult patients who had received a HCT at our centre were invited to participate in a professionally facilitated support group. The format of the group was unstructured without any rules regarding regular attendance. The attendance was prospectively minuted by the facilitator. Reasons for non-attendance were assessed by a survey.

Results

During the observation period, 53 group meetings were scheduled. Nine meetings were cancelled because of low attendance. Altogether 23 different patients (F: n=10; M: n=13) and 10 spouses (F: n=9; M: n=1) participated. Median participation was 5 [range 2–11]. With respect to all HCT patients who had the theoretical opportunity to attend, the mean participation rate was 7%. Thirteen patients and four spouses attended more than one meeting. The median count of participations among those participants was 8 [2-32]. The median interval from the first until the last participation was 16 months. The main reason reported for non-participation was the effort to get to the venue of the support group.

Conclusions

To our knowledge, this is the first analysis on the attendance behaviour of the participants of a support group for HCT survivors. The results provide guidance for the organization of future support groups and indicate what participation rates can be expected and how they might be increased.
Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity
Authors: Seebacher Werner , Hoffelner Michael , Belaj Ferdinand , Kaiser Marcel , Mäser Pascal , Saf Robert , Pferschy-Wenzig Eva-Maria , Weis Robert
Published: December 2023

Tetrahydropyridin-4-ylidene salts with benzyl and dibenzyl substitution showed good antiprotozoal activity. This paper reports the synthesis of analogues with longer side chains. They were investigated for their antiprotozoal activities as well as for their cytotoxicity using microplate assays. The most active compounds showed activity against Trypanosoma brucei rhodesiense in concentrations < 0.06 µM. A series of compounds was active against Plasmodium falciparum NF54 in low nanomolar concentration and exhibited outstanding selectivity. The influence of substitution pattern and chain length on the antiprotozoal potencies were analyzed and structure–activity relationships were given. New compounds were characterized by FT-IR, HRMS, and NMR spectroscopy.

Graphical abstract
DB-BERT: making database tuning tools “read” the manual
Authors: Trummer Immanuel
Published: December 2023

DB-BERT is a database tuning tool that exploits information gained via natural language analysis of manuals and other relevant text documents. It uses text to identify database system parameters to tune as well as recommended parameter values. DB-BERT applies large, pre-trained language models (specifically, the BERT model) for text analysis. During an initial training phase, it fine-tunes model weights in order to translate natural language hints into recommended settings. At run time, DB-BERT learns to aggregate, adapt, and prioritize hints to achieve optimal performance for a specific database system and benchmark. Both phases are iterative and use reinforcement learning to guide the selection of tuning settings to evaluate (penalizing settings that the database system rejects while rewarding settings that improve performance). In our experiments, we leverage hundreds of text documents about database tuning as input for DB-BERT. We compare DB-BERT against various baselines, considering different benchmarks (TPC-C and TPC-H), metrics (throughput and run time), as well as database systems (PostgreSQL and MySQL). The experiments demonstrate clearly that DB-BERT benefits from combining general information about database tuning, mined from text documents, with scenario-specific insights, gained via trial runs. The full source code of DB-BERT is available online athttps://itrummer.github.io/dbbert/.
Interpretation of hydrogeochemistry of the Upper Freshwater Molasse (Obere Süßwassermolasse) in the Munich area (Bavaria, Germany) using multivariate analysis and three-dimensional geological modelling
Authors: Kiecak Aleksandra , Huch Jan , Albarrán-Ordás Alberto , Chavez-Kus Lilian , Zosseder Kai
Published: December 2023

Intense use of groundwater in urban areas requires appropriate monitoring, which in turn necessitates proper data management with employment of increasingly sophisticated statistical methods and mapping tools. An example of such an urban area with intensive use of groundwater is the study area of GeoPot Project, namely Munich (Germany) and its surroundings. The aim of the presented study was to provide a description of the hydrogeochemical characteristics of the aquifers occurring in the Quaternary and Upper Freshwater Molasse (German: Obere Süßwassermolasse – OSM) sediments and to further improve the understanding of interactions between the aquifers. The focus was put on the identification of hydrochemical facies, the chemical signatures of different water types, an understanding of occurring processes, and spatial relationships between the aquifers. In order to deal with hydrogeochemical data generated for this study, as well as with data coming from existing external databanks (e.g. BIS-BY), a methodology of quality assurance was developed. The analytical methods focused on multivariate statistics. To enhance the interpretation of the obtained clusters, a recently developed three-dimensional geological model was used for better understanding and presentation. It was found that in the study area, deeper aquifer systems represent the most distinct hydrogeochemical signature of the Na–HCO3 water type. In the remaining clusters, a transition from deeper (alkaline) to shallow (alkaline-earth) groundwater can be observed. The results of the study can be utilized for improved, sustainable groundwater management.
Neurosurgical treatment and outcome patterns in patients with meningioma in South Moravian region—a population-based study
Authors: Duba Miloš , Mrlian Andrej , Rošková Ivana , Smrčka Martin , Fadrus Pavel , Duba Jaroslav , Hrdý Ondřej , Al Tukmachi Dagmar
Published: December 2023

Introduction

Meningiomas are usually slow-growing tumours, constituting about one third of all primary intracranial tumours. They occur more frequently in women. Clinical manifestation of meningiomas depends on their location, tumour size and growth rate. In most cases, surgical treatment is the procedure of choice. The success of this treatment is, however, associated with the radicality of the resection. Radiotherapy represents an additional or alternative treatment modality. Gamma knife surgery is another notable treatment method, especially in small and/or slow-growing tumours in eloquent areas or in elderly patients.

Material and methods

Authors describe their experience with the diagnosis, treatment and outcome of the patients with meningioma (n = 857). Furthermore, they also assess the postoperative morbidity/mortality and recurrence rate.

Results and conclusions

In view of the benign histology of meningiomas, the success of the treatment largely depends (besides the tumour grading) on the radicality of the resection. The emphasis is also put on appropriate follow-up of the patients. In certain patients, the watch and wait strategy should be also considered as a suitable treatment method.
Investigation of both thermal parameters and applications of closed-cell plastic thermal insulation foams with building energetic aspects
Authors: Lakatos Ákos , Csontos Máté , Csík Attila
Published: December 2023

Nowadays, if one wants to renovate or build a building, the question of thermal insulation is an essential construction process. Polyurethane is a key thermal insulation material that belongs to plastic foams. It can be applied as a spread or board heat-insulating material. Its thermal insulation properties are superior compared to polystyrene, but still a bit neglected. In this article, we would like to perform thermal investigations executed on a new type of polymeric foam such as polyisocyanurate. We will present acceptably low thermal conductivity (~ 0.022 W m-1 k-1), raised specific heat capacity (~ 1400 J kg-1 K-1) and calorimetric (bomb and differential) measurement results completed with optical microscopic images. Moreover, scanning electron microscopic analysis and X-ray diffractometry will be also presented. The results will be used for cost calculations applied by buildings and will show justified reasons for its application based on structural measurements too. The results are extremely encouraging.
Discrepancies among equations to estimate the glomerular filtration rate for drug dosing decision making in aged patients: a cross sectional study
Authors: Castel-Branco M. Margarida , Lavrador Marta , Cabral Ana C. , Pinheiro Adriana , Fernandes Joana , Figueiredo Isabel Vitória , Fernandez-Llimos Fernando
Published: December 2023

Background

Patients often require adjustments to drug doses due to impaired renal function. Glomerular filtration rate (GFR) estimation using various equations can result in discrepancies, potentially leading to different dose adjustment recommendations.

Aim

To determine the clinical significance of discrepancies observed between different equations used to estimate GFR for drug dose adjustments in a real-world group of patients over 65 years in primary care.

Method

The Cockcroft–Gault (CG), Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Berlin Initiative Study 1 equations were applied to estimate GFR in a group of patients over 65 years old attending a primary care center. Results were compared using Bland–Altman plots, and limits of agreement (LoA) and overall bias were calculated. Regression analyses were conducted to identify the null difference GFR and the slope of differences for each pairwise comparison.

Results

A total of 1886 patients were analyzed. Differences between patient-adjusted and body surface area (BSA)-normalized versions of the equations were not clinically relevant for dose adjustments, with LoAs below 20 mL/min. However, discrepancies among the original versions of several equations presented LoAs over 30 mL/min. Greater differences were found between CG and MDRD or CKD-EPI equations.

Conclusion

Clinically relevant differences in GFR estimation were observed among different equations, potentially impacting drug dose adjustments. However, discrepancies were not considered significant when comparing patient-adjusted and BSA-normalized versions of the equations, particularly for patients with BSA close to the average.
Promoting explicit instruction of strategies for self-regulated learning: evaluating a teacher professional development program in primary education
Authors: Sins Patrick , de Leeuw Renske , de Brouwer Jaap , Vrieling-Teunter Emmy
Published: December 2023

Self-regulated learning (SRL) is crucial to students’ learning. SRL is characterized by students taking initiative, showing perseverance and adaptively regulating their learning. Teachers play an essential role in promoting and fostering this process. However, several studies have shown that in primary education explicit instruction of SRL strategies barely takes place. Given the relevance of SRL for learning and preparing students for the knowledge society of the 21st century, it is of crucial importance that teachers in primary education learn how they can improve their students’ SRL. In the present study, we implemented a professional development program (iSELF) in which primary teachers were trained and coached in promoting and fostering their students’ SRL. The extent to which iSELF contributed to teachers’ explicit instruction of SRL strategies was evaluated in a quasi-experimental pre-test-post-test design using video-based classroom observations. Thirty teachers from fourteen different primary schools participated in this study and were assigned to either a control (twelve teachers) or an experimental group (eighteen teachers). Results indicate that in both conditions explicit SRL strategy instruction is rare. However, explicit instruction of SRL strategies is significantly higher in the experimental group on the post-test compared to the control group showing that teachers do benefit from learning about explicit SRL instruction.
Long-term variability of the MERRA-2 radiation budget over Poland in Central Europe
Authors: Markowicz Krzysztof M. , Okraska Igor , Chiliński Michał T. , Makuch Przemysław , Nurowska Katarzyna , Posyniak Michał A. , Rozwadowska Anna , Sobolewski Piotr , Zawadzka-Mańko Olga
Published: December 2023

This paper discusses the radiation budget and its temporal variability over Poland. The data analysis is based on the MERRA-2 reanalysis for the years 1980–2020. During the last four decades, the enhancement of climate warming has been observed, which coincides with the changes in the radiation budget. Positive and statistically significant trends at the top of the atmosphere (TOA; 0.7 ± 0.2 W/m2/10 year) and on the Earth’s surface (1.5 ± 0.2 W/m2/10 year) radiation budget (net downward flux) are mainly a consequence of changes in the amount of aerosol and greenhouse gases (GHG). According to MERRA-2, the AOD during this period decreased by − 0.19 (at 550 nm), which is 87% of the long-term (1980–2021) mean value (0.22). The reduction of AOD is due mainly to the decline of non-absorbing sulfate particles, which leads to a reduction of single-scattering albedo (SSA) by − 0.008 per decade and Angstrom exponent (AE) by − 0.06 per decade (both trends statistically significant). On the other hand, the GHG concentration increased by 4.9%/10 year and 3%/10 year, respectively, for CO2 and CH4. The total column of water vapor increased (1.3%/10 year), while ozone decreased (− 1%/10 year). Despite the fact that cloud cover and cloud optical depth (COD) decreased (− 1.8%/10 year and − 1.0%/10 year), the impact of cloud on temporal variability radiation budget is small. It can be explained by nearly compensated shortwave (SW) cooling and longwave (LW) heating effects. During the analysis period, near-surface air temperature increased by 2.0 °C. The estimated increase in SW net surface radiation (7.9 W/m2) leads to climate warming by 0.8 °C, which is a consequence mainly of the reduction of aerosol (0.4 °C) and cloud cover (0.2 °C). The impact of the change of SW radiation on air temperature is more pronounced during the warm season, while during the cold, air temperature change is controlled mainly by the variability of air mass advection.
Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
Authors: Ma Yunyun , Wang Lei , He Jing , Ma Xueping , Wang Jingjing , Yan Ru , Ma Wanrui , Ma Huiyan , Liu Yajuan , Sun Hongqian , Zhang Xiaoxia , Jia Shaobin , Wang Hao
Published: December 2023

Silver nanoparticles (AgNP) are the dominant nanomaterials in commercial products and the medical field, but the widespread occurrence of AgNP has become a global threat to human health. Growing studies indicate that AgNP exposure can induce vascular endothelial toxicity by excessive oxidative stress and inflammation, which is closely related to cardiovascular disease (CVD), but the potential intrinsic mechanism remains poorly elucidated. Thus, it has been crucial to control the toxicological effects of AgNP in order to improve their safety and increase the outcome of their applications.

Multiple researches have demonstrated that sodium selenite (Se) possesses the capability to counteract the toxicity of AgNP, but the functional role of Se in AgNP-induced CVD is largely unexplored. The aim of this study was to explore the potential protective effect of Se on AgNP-induced vascular endothelial lesion and elucidate the underlying mechanisms. An in vivo model of toxicity in animals was established by the instillation of 200 µL of AgNP into the trachea of rats both with (0.2 mg/kg/day) and without Se treated. In vitro experiments, human umbilical vein endothelial cells (HUVECs) were incubated with AgNP (0.3 µg/mL ) and Se for a duration of 24 h. Utilizing transmission electron microscopy, we observed that the internalization of AgNP-induced endothelial cells was desquamated from the internal elastic lamina, the endoplasmic reticulum was dilated, and the medullary vesicle formed. Se treatment reduced the levels of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), inhibited the release of pro-inflammatory cytokines (specifically tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6), improved endothelial cell permeability, integrity, and dysfunction, and prevented damage to the aortic endothelium caused by AgNP. Importantly, we found that Se showed the capacity against AgNP with biological functions in guiding the intracellular reactive oxygen species (ROS) scavenging and meanwhile exhibiting anti-inflammation effects. Se supplementation decreased the intracellular ROS release and suppressed NOD-like receptor protein 3 (NLRP3) and nuclear factor kappa-B (NF-κB) mediated inflammation within AgNP-intoxicated rats and HUVECs. The anti-oxidant stress and anti-inflammatory effects of Se were at least partly dependent on nuclear factor erythroid 2-related factor 2 (Nrf2). Overall, our results indicated that the protectiveness of Se against AgNP-induced vascular endothelial toxicity injury was at least attributed to the inhibition of oxidative ROS and pro-inflammatory NF-κB/NLRP3 inflammasome by activating the Nrf2 and antioxidant enzyme (HO-1) signal pathway.
Deep learning to develop zero-equation based turbulence model for CFD simulations of the built environment
Authors: Calzolari Giovanni , Liu Wei
Published: December 2023

This study aims to improve the accuracy and speed of predictions for thermal comfort and air quality in built environments by creating a coupled framework between computational fluid dynamics (CFD) simulations and deep learning models. The coupling approach is showcased by the development of a data-driven turbulence model. The new turbulence model is built using a deep learning neural network, whose mapping structure is based on a zero-equation turbulence model for built environment simulations, and is coupled with the CFD software OpenFOAM to create a hybrid framework. The neural network is a standard shallow multi-layer perceptron. The number of hidden layers and nodes per layer was optimized using Bayesan optimization algorithm. The framework is trained on an indoor environment case study, as well as tested on an indoor office simulation and an outdoor building array simulation. Results show that the deep learning based turbulence model is more robust and faster than traditional two-equation Reynolds average Navier-Stokes (RANS) turbulence models, while maintaining a similar level of accuracy. The model also outperforms the standard algebraic zero-equation model due to its superior ability to generalize to various flow scenarios. Despite some challenges, namely the mapping constraint, the limited training dataset size and the source of generation of training data, the hybrid framework demonstrates the viability of the coupling technique and serves as a starting point for future development of more reliable and advanced models.
Asymptotic Behavior of Solutions to Difference Equations of Neutral Type
Authors: Nockowska-Rosiak Magdalena , Migda Janusz
Published: December 2023

We present sufficient conditions for the existence of a solution x to an equation $$\begin{aligned} \Delta ^m(x_n-u_nx_{n-k})=a_nf(x_{n-\tau })+b_n, \end{aligned}$$

Δ
m

(

x
n

-

u
n

x

n
-
k

)

=

a
n

f

(

x

n
-
τ

)

+

b
n

,

which is “close” to a given solution y to the linear homogeneous equation of neutral type $$\Delta ^m(y_n-\lambda y_{n-k})=0$$

Δ
m

(

y
n

-
λ

y

n
-
k

)

=
0

, where $$\lambda $$
λ
is the limit of the sequence u. Closeness of solutions to above equations is understood as $$x_n-y_n=\textrm{o}(\omega _n)$$

x
n

-

y
n

=
o

(

ω
n

)

, where $$\omega $$
ω
is a given nonincreasing sequence with positive values. Moreover, we establish under which conditions for a given solution x to $$\Delta ^m(x_n-u_nx_{n-k})=a_nf(x_{n-\tau })+b_n$$

Δ
m

(

x
n

-

u
n

x

n
-
k

)

=

a
n

f

(

x

n
-
τ

)

+

b
n

and a given nonincreasing sequence with positive values $$\omega $$
ω
there exists a polynomial sequence $$\varphi $$
φ
of degree less than m such that $$x_n=\varphi (n)+\textrm{o}(\omega _n)$$

x
n

=
φ

(
n
)

+
o

(

ω
n

)

. Presented conditions strongly depend on $$\lambda $$
λ
.
Lack of microbiological awareness on the ward as a key factor for inappropriate use of anti-infectives: results of a point prevalence study and user satisfaction survey in a large university hospital in Austria
Authors: Kern Jan Marco , Berger Karoline , Lechner Arno Michael , Porsche Ulrike , Wallner Markus , Past Eva Maria
Published: December 2023

Purpose

Although diagnostic stewardship issues in clinical microbiology harbor an optimization potential for anti-infective consumption, they are only marginally addressed in antimicrobial stewardship (AMS) programs. As part of an AMS point prevalence (PPS) survey we therefore aimed to gain a more dynamic view on the microbiological awareness within therapeutic regimens. By examining whether initial microbiological sampling was performed and in which way microbiological results were incorporated into further treatment considerations we sought to find out to what extent these points determine the appropriateness of treatment regimens.

Methods

PPS was performed at the University Hospital Salzburg (1524 beds) in May 2021. Relevant data was determined from the patient charts and the appropriateness of anti-infective use was assessed using predefined quality indicators. Six months after the PPS, a questionnaire was administered to clinicians to obtain information on the use of microbiological findings and their relevance in the clinic.

Results

Lack of microbiological awareness in the clinical setting proved to be the key reason for an overall inadequate use of anti-infectives (35.4% of cases rated as inadequate), ahead of the aspects of dose (24.1%), empirical therapy (20.3%) and treatment duration (20.2%). This was particularly the case for broad-acting agents and was most evident in urinary tract infections, skin and soft tissue infections, and pneumonia. The results of the questionnaire indicate a discrepancy between the physicians surveyed and the routine clinical setting.

Conclusion

A high potential in improving the use of anti-infectives in hospitals seems to lie in a strong emphasis on microbiological diagnostic stewardship measures.
The Epistemological Asymmetry of Framing “Woman” via US Women's Rights Pioneers
Authors: Bickell Lauren
Published: December 2023

Nineteenth-century US social activist contemporaries Elizabeth Cady Stanton, Susan B. Anthony, and Sojourner Truth are memorialized as women's rights pioneers. White activists Elizabeth Cady Stanton and Susan B. Anthony cemented a generational canon. Black activist Sojourner Truth anticipated the eventual crystallization of intersectionality. These figures’ historical proximity underscores the high epistemological and political stakes of claiming gendered categories, namely via “woman” as a mark of aggrievement. I link concepts of intersectionality, epistemic agency, epistemic resources, and social movement framing to examine how “woman” is asymmetrically categorized. To this end, I perform a textual analysis of memorialized documents: “Declaration of Sentiments” (1848) by Elizabeth Cady Stanton, “Declaration of Rights of the Women of the United States” (1876) by Susan B. Anthony, and “Ain't I a Woman?” (1851) by Sojourner Truth. Elizabeth Cady Stanton and Susan B. Anthony frame “woman” as a single-axis and vertical category, ultimately deferring to the seeming preeminence of the US nation-state. By contrast, Sojourner Truth frames “woman” as a multi-axis and horizontal category by synthesizing her feminist consciousness, lived experience of enslavement, and personal religiosity. This article revisits key memorialized events by utilizing a conceptual toolkit that interlaces feminist and social epistemology with social movement theory.
Healthcare-based food assistance programmes in the United States: a scoping review and typology
Authors: Rudel Rebecca K. , Byhoff Elena , Strombotne Kiersten L. , Drainoni Mari-Lynn , Greece Jacey A.
Published: December 2023

This scoping review aimed to identify the breadth of healthcare-based food assistance programmes in the United States and organize them into a typology of programmes to provide implementation guidance to aspiring food assistance programmers in healthcare settings. We searched PubMed, Cochrane, and CINAHL databases for peer-reviewed articles published between 1 January 2010 and 31 December 2021, and mined reference lists. We used content analysis to extract programmatic details from each intervention and to qualitatively analyse intervention components to develop a typology for healthcare institutions in the United States. Eligible articles included descriptions of patient populations served and programmatic details. Articles were not required to include formal evaluations for inclusion in this scoping review. Our search resulted in 8706 abstracts, which yielded forty-three articles from thirty-five interventions. We identified three distinct programme types: direct food provision, referral, and voucher programmes. Programme type was influenced by programme goals, logistical considerations, such as staffing, food storage or refrigeration space, and existence of willing partner CBOs. Food provision programmes (n 13) were frequently permanent and leveraged partnerships with community-based organisations (CBOs) that provide food. Referral programmes (n 8) connected patients to CBOs for federal or local food assistance enrollment. Voucher programmes (n 14) prioritised provision of fruits and vegetables (n 10) and relied on a variety of clinic staff to refer patients to months-long programmes. Healthcare-based implementers can use this typology to design and maintain programmes that align with the needs of their sites and patient populations.
Various topological complexities of small covers and real Bott manifolds
Authors: Brahma Koushik , Naskar Bikramaditya , Sarkar Soumen , Sau Subhankar
Published: December 2023

In this paper, we compute the LS-category and equivariant LS-category of a small cover and its real moment angle manifold. We calculate a tight lower bound for the topological complexity of many small covers over a product of simplices. Then we compute symmetric topological complexity of several small covers over a product of simplices. We calculate the LS one-category of real Bott manifolds and infinitely many small covers.
Total and segmental phase angle in a cohort of hospitalised patients with COVID-19: mortality prediction and changes throughout hospitalisation
Authors: Estrada-Moya Fernando , González-Garay Alejandro G. , Flores-López Adriana , Serralde-Zúñiga Aurora E.
Published: December 2023

Body composition and phase angle (PhA) have been used to predict mortality in multiple diseases. However, little has been studied regarding segmental measurements, which could potentially help assess subtle changes in specific tissue segments. This study aimed to identify the total PhA cut-off point associated with mortality risk and changes in body composition within a week of hospitalisation in non-critical hospitalised patients with COVID-19. A cohort study was conducted where patients underwent to a complete nutritional assessment upon admission and after seven days, and followed up until hospital discharge or death. A receiver operating characteristic curve was constructed to determine the PhA cut-off point, and the Kaplan–Meier estimator was used to determine survival analysis. Segmental and complete body compositions on admission and after 7 d were compared. We included 110 patients (60 men) with a mean age of 50·5 ± 15·0 years and a median BMI of 28·5 (IQR, 25·6–33·5) kg/m2. The median length of hospital stay was 6 (IQR, 4–9) d, and the mortality rate was 13·6 %. The PhA cut-off point obtained was 4°, with significant differences in the survival rate (P < 0·001) and mortality (HR = 5·81, 95 % CI: 1·80, 18·67, P = 0·003). Segmental and whole-body compositions were negatively affected within one week of hospitalisation, with changes in the approach by the graphical method in both sexes. Nutritional status deteriorates within a week of hospitalisation. PhA < 4° is strongly associated with increased mortality in non-critical hospitalised patients with COVID-19.
Systems approaches to public service delivery: methods and frameworks
Authors: Mansoor Zahra , Williams Martin J.
Published: December 2023

Researchers and practitioners are increasingly embracing systems approaches to deal with the complexity of public service delivery and policy evaluation. However, there is little agreement on what exactly constitutes a systems approach, conceptually or methodologically. We review and critically synthesize systems literature from the fields of health, education, and infrastructure. We argue that the common theoretical core of systems approaches is the idea that multi-dimensional complementarities between a policy and other aspects of the policy context are the first-order problem of policy design and evaluation. We distinguish between macro-systems approaches, which focus on the collective coherence of a set of policies or institutions, and micro-systems approaches, which focus on how a single policy interacts with the context in which it operates. We develop a typology of micro-systems approaches and discuss their relationship to standard impact evaluation methods as well as to work in external validity, implementation science, and complexity theory.
Geninka and Slavery: Jesuit Casuistry and Tokugawa Legislation on Japanese Bondage (1590s–1620s)
Authors: Ehalt Rômulo
Published: December 2023

Based on Japanese and Portuguese sources, this paper aims at recovering local categories of bondage in order to identify mechanisms by which people were subjected to bonded labour in early modern Japan. The analysis focuses on crossing local forms of bondage, here referred to as genin, and the processes of subjecting individuals to this condition, the so-called called geninka, with the European notion of slavery and enslavement. Local forms of subjection to bondage are drawn from the analysis of early seventeenth-century Tokugawa legislation dedicated to the suppression of human trafficking networks. These documents use a number of labels such as genin, hōkōnin, wakatō, chūgen, hikan, and komono, all references to people subjected to various forms of bondage. At the same time, a crucial debate among members of the Society of Jesus in India offers the opportunity to scrutinise the application of the historical and legal European concept of slavery and enslavement to Japan, a region beyond the secular authority of colonial empires. Ultimately, slavery reveals itself as one of the many categories used by early modern actors to interpret and regulate labour arrangements in the budding Christian communities created by missionaries in the Iberian world.
FBi-RRT: a path planning algorithm for manipulators with heuristic node expansion
Authors: Xiao Guangzhou , Zhang Lixian , Wu Tong , Han Yuejiang , Ding Yihang , Han Chengzhe
Published: December 2023

This paper is concerned with the problem of collision-free path planning for manipulators in multi-obstacle scenarios. Aiming at overcoming the deficiencies of existing algorithms in excessive time consumption and poor expansion quality, a path planning algorithm named Fast Bi-directional Rapidly-exploring Random Tree (FBi-RRT) with novel heuristic node expansion is proposed, which includes a selective-expansion strategy and a vertical-exploration strategy. The selective-expansion strategy is designed to guide the selection of the nearest-neighbor node to avoid the repeated expansion failure, thereby shortening the overall planning time. Also, the vertical-exploration strategy is developed to regulate the expansion direction of the collision nodes to escape from the obstacle space with less blindness, thus improving the expansion quality and further reducing time cost. Compared with previous planning algorithms, FBi-RRT can generate a feasible path for manipulators in a drastically shorter time. To validate the effectiveness of the proposed heuristic node expansion, FBi-RRT is conducted on a 6-DOF manipulator and tested in five scenarios. The experimental results demonstrate that FBi-RRT outperforms the existing methods in time consumption and expansion quality.
Ultrastructural study:in vitroandin vivodifferentiation of mice spermatogonial stem cells
Authors: Bashiri Zahra , Movahedin Mansoureh , Pirhajati Vahid , Asgari Hamidreza , Koruji Morteza
Published: December 2023

Mouse testicular tissue is composed of seminiferous tubules and interstitial tissue. Mammalian spermatogenesis is divided into three stages: spermatocytogenesis (mitotic divisions) in which spermatogonial stem cells (SSCs) turn into spermatocytes, followed by two consecutive meiotic divisions in which spermatocytes form spermatids. Spermatids differentiate into spermatozoa during spermiogenesis. Various factors affect the process of spermatogenesis and the organization of cells in the testis. Any disorder in different stages of spermatogenesis will have negative effects on male fertility. The aim of the current study was to compare thein vitroandin vivospermatogenesis processes before and after transplantation to azoospermic mice using ultrastructural techniques. In this study, mice were irradiated with single doses of 14 Gy60Co radiation. SSCs isolated from neonatal mice were culturedin vitrofor 1 week and were injected into the seminiferous tubule recipient’s mice. Testicular cells of neonatal mice were cultured in the four groups on extracellular matrix-based 3D printing scaffolds. The transplanted testes (8 weeks after transplantation) and cultured testicular cellsin vitro(after 3 weeks) were then processed for transmission electron microscopy studies. Our study’s findings revealed that the morphology and ultrastructure of testicular cells after transplantation andin vitroculture are similar to those ofin vivospermatogenesis, indicating that spermatogenic cell nature is unalteredin vitro.
Influence of improved antenatal detection on the outcomes of complete atrioventricular block diagnosed in fetal-neonatal life and childhood periods – a single-centre experience in South Wales for 55 years
Authors: Duman Derya , Tunca Sahin Gulhan , Stuart Graham , Walsh Mark , Caputo Massimo , Parry Andrew , Beattie Bryan , Conner Christine , Uzun Orhan
Published: December 2023

Objective:

This study aimed to analyse the influence of improved antenatal detection on the course, contemporary outcomes, and mortality risk factors of the complete atrioventricular block during fetal-neonatal and childhood periods in South Wales.

Methods:

The clinical characteristics and outcomes of complete atrioventricular block in patients without structural heart disease at the University Hospital of Wales from January 1966 to April 2021 were studied. Patients were divided into two groups according to their age at diagnosis: I-fetal-neonatal and II-childhood. Contemporary outcomes during the post-2001 era were compared with historical data preceding fetal service development and hence earlier detection.

Results:

There were 64 patients: 26 were identified in the fetal-neonatal period and the remaining 38 in the childhood period. Maternal antibodies/systemic lupus erythematosus disease (anti-Ro/Sjögren’s-syndrome-related Antigen A and/or anti-La/Sjögren’s-syndrome-related Antigen B) were present in 15 (57.7%) of the fetal-neonatal. Fetal/neonatal and early diagnosis increased after 2001 with an incidence of 1:25000 pregnancies. Pacemaker implantation was required in 34 patients, of whom 13 were diagnosed in the fetal-neonatal group. Survival rates in cases identified before 2001 were at 96.3% (26/27), whereas it was 83.8% (31/37) in patients diagnosed after 2001 (P > 0.05). Other mortality risk factors comprised a lower gestational week at birth, maternal antibodies, and an average ventricular heart rate of < 55 bpm.

Conclusions:

Fetal diagnosis of complete atrioventricular block is still portends high fetal and neonatal mortality and morbidity despite significantly improved antenatal detection after 2001. Pacemaker intervention is needed earlier in the fetal-neonatal group. Whether routine antenatal medical treatment might alter this outcome calls for further prospective multicentre studies.