bluuebunny/crossref_metadata_2025 huggingface dataset:
A estratégia de incorporação dos critérios de compras públicas sustentáveis em uma universidade federal
Authors: Silveira Glaucia Bambirra , Oliveira Keilla Dayane Da Silva , Silva Artur Leonardo Imamura Ferreira da , Santos Isabel Cristina dos
Published: December 2020

Objetivo: Relatar quais as estratégias e intervenções desenvolvidas na implantação dos critérios de sustentabilidade nas compras públicas realizadas no âmbito da instituição de ensino superior brasileira.Metodologia: A pesquisa possui abordagem qualitativa do tipo exploratório, com a aplicação da técnica de observação participante e análise documental, ocorridas entre março de 2015 a março de 2020.Originalidade/Relevância: Esse trabalho contribui para a discussão sobre o processo de implementação das compras públicas sustentáveis e as estratégias utilizadas para maior eficiência.Resultados: Os principais resultados indicaram que a Universidade Federal do ABC (UFABC) está em fase avançada de implementação dos critérios de compras sustentáveis, que ocorrem de forma institucionalizada e em obediência às normas públicas de aquisições e contratações promulgadas pelo Poder Público Federal, inclusive com a aceitação e o envolvimento dos servidores da universidade.Contribuições/ implicações: A experiência da UFABC contribui para a disseminação do conhecimento sobre as etapas percorridas por uma instituição de ensino público na implementação dos critérios de sustentabilidade nas compras públicas.
A teoria dos stakeholders no Brasil: produção acadêmica no período de 2014 a 2019
Authors: Menezes David Curtinaz , Vieira Diego Mota , Santos Andersson Pereira dos
Published: December 2020

Objetivo: Analisar o perfil da produção recente sobre Teoria dos Stakeholders nos periódicos nacionais.Método: Revisão de literatura, na qual foram selecionados 271 artigos publicados, entre 2014 e 2019, em 92 periódicos do estrato superior do Qualis/CAPES em Administração e áreas afins. Originalidade/Relevância: O conhecimento acerca do referido perfil auxilia os pesquisadores a visualizarem aspectos metodológicos e conceituais a partir dos quais o tema está sendo discutido, contribuindo para a definição de uma agenda de pesquisa.Resultados: A RBGN, a RAUFSM e a RIAE são os periódicos de referência. A maioria dos estudos adota uma abordagem teórico-empírica e possui natureza qualitativa, sendo a pesquisa documental e a entrevista os instrumentos de coleta de dados mais utilizados. A análise de conteúdo foi a técnica de análise de dados mais aplicada. A definição de Stakeholder de Freeman e o modelo de análise de Mitchell, Agle e Wood são os mais empregados. A pesquisa sobre o tema é crescentemente colaborativa, bem como foi possível constatar a validação das Leis de Bradford e Zipf, mas não a de Lotka. Portanto, é possível identificar um grupo de periódicos mais devotos ao tema e os termos que apresentam maior frequência nos artigos pesquisados. Entretanto, não foi possível comprovar que uma larga proporção da literatura foi produzida por um pequeno número de autores. Contribuições teóricas/metodológicas: Foram identificadas lacunas na literatura e tendências, como o diálogo entre a Teoria de Stakeholder e a geração de valor, que foram objeto da agenda de pesquisa sugerida.
Can I confidently guess who you are? Personality and intelligence perception in online dating
Authors: von Andrian-Werburg Maximilian T. P. , Adler Dorothea C. , Schwab Frank , Schwarz Sascha , Lange Benjamin P.
Published: December 2020

We conducted two computer-mediated speed dating studies to evaluate personality perception based on language use in online dating and analyzed the data with Bayesian statistics. In each study, participants first reported mating-relevant personality traits (Big Five, sociosexual orientation) and we assessed their intelligence (N1 = 186, N2 = 618). Subsequently, we conducted computer-mediated speed dating sessions at our laboratory (n1 = 56, n2 = 94). After the first chat, participants rated their chat partner on the constructs mentioned above (i.e., personality and intelligence). Linguistic patterns in the chats were analyzed using LIWC. In both studies, consistent evidence showed that online daters systematically rated partners with higher IQ and extraversion scores as more intelligent and extraverted above chance. We also derived different linguistic cues as potential mediators from earlier studies. Empirical evidence proved very strongly against mediation based on such linguistic cues. Hence, although people are able to make correct inferences about the personality and intelligence of potential mates in the dynamic setting of speed dating, it remains unclear which cues they rely on.
Long Term Effects of Juvenile Correctional Confinement
Authors: Erickson Gina , Schaefer Shelly
Published: December 2020

Justice-involved adolescents face significant roadblocks in the transition to adulthood when they navigate this period while simultaneously re-entering the community after a period of confinement. This study investigates how confinement disrupts psychosocial development across the transition to adulthood using data from the National Longitudinal Study of Adolescent Health to compare psychological well-being and psychosocial development for youth confined before age 18, those arrested before age 18 but not confined, and those with no criminal justice involvement in adolescence. Findings show significantly lower levels of psychological well-being for confined youth compared to all other youth. Females who were confined during adolescence were especially low levels of psychological well-being in young adulthood. Subsequently, confined youth have lower levels of educational and employment attainment in young adulthood. Results suggest the need for juvenile facilities to incorporate programming that builds psychosocial skills and well-being.
A report of successful management with simvastatin plus ezetimibe in alopecia areata
Authors: Arellano Javier , Carrasco Carolina , García Carolina
Published: December 2020

Alopecia areata is a common type of non-scarring alo¬pecia. Although the exact pathogenesis remains elusive, alopecia areata is thought to have a multifactorial etiology described as an interplay of genetic predisposition and environmental exposures. In patients with genetic susceptibility, stress, infection, and microtrauma have been documented to decrease immunosuppressive cytokines that generally maintain the hair follicle's immune privilege. There is currently no curative therapy for alopecia areata, although some treatments can induce hair growth in a percentage of patients. It has been postulated that simvastatin reestablishes the immune privilege, and ezetimibe would provide an immunomodulatory and anti-inflammatory effect. We report a case of a 23 years-old woman with alopecia areata successfully treated with simvastatin/ezetimibe.
International business and management in pandemic-related conditions
Authors: Stojadinović-Jovanović Sandra , Krstić Bojan , Marković Milan
Published: December 2020

The aim of the paper is to give the insight into international business and management in pandemic-related conditions in the first half of 2020. The subject of the paper is the analysis of the impact of the initial pandemic wave on the conditions in which international business and management take place and the risks to which companies are exposed, the ways they react to these conditions regarding the business ventures they give up or undertake, as well as the possibilities of how to cope with the current pandemic conditions. Therefore, the paper consists of three parts which analyze each of these aspects. In the pandemic-related conditions, full of unknowns and declining trends of almost all economic indicators, managers have a significant and additional responsibility to consider all relevant aspects and act accordingly making possibilities to mitigate the effects of a pandemic and to get through it.
Who are the pupils with low scores on achievement tests in TIMSS research: Comparative analysis
Authors: Đerić Ivana , Đević Rajka , Malinić Dušica
Published: December 2020

This paper focuses on the fourth-grade elementary school pupils who achieved low scores on the TIMSS test in mathematics and natural sciences. In order to examine certain characteristics of these pupils, two research questions were posed: (1) What makes the low-achieving pupils in Serbia different from other pupils from the same sample in terms of personal and family characteristics? (2) Do the low-achieving pupils from Serbia, Croatia, and Slovenia differ at the level of personal, family, teaching, and school characteristics? The data were analyzed in two subsamples. One subsample included only the pupils from Serbia (N = 4036), while the other referred to the low-achieving pupils from three compared countries (N = 1876). The research results indicate that in Serbia, the low-achieving pupils differ significantly from other pupils in terms of some individual and family characteristics - they attended preschool institutions in a smaller number and spent less time in them, were less prepared for starting elementary school, were absent more frequently from school, and had less educated parents. There are also noticeable differences between our low-achieving pupils and their peers from the region who achieved similar results. For example, the pupils from Serbia had less educated parents and a smaller number of those who had professional occupations, fewer educational resources for learning at home, but they showed greater mathematical self-confidence and had a more pronounced experience of belonging to their school. The key implications of this research have been highlighted and its advantages and limitations pointed out.
On vocabulary learning strategies among students of foreign languages
Authors: Stanojević Slađana , Petrović Ana
Published: December 2020

Adequate and purposeful use of vocabulary is one of the primary goals of the process of learning and teaching a foreign language, given that the success in building language competence largely depends on it. Vocabulary learning strategies, as a diverse set of techniques focused on overcoming the various problems that arise when learning words, can help students to achieve this complex goal in the easiest and fastest way possible. While some strategies can be applied spontaneously, teaching practice and research (Oxford, 1990; Gu and Johnson, 1996; Schmitt, 1997; Fan, 2003; Šikmanović, 2013) indicate that students are often unaware of the breadth of the range of strategies at their disposal. The main goal of the research presented in this paper is to provide an insight into the attitudes of students of foreign languages towards the use of vocabulary learning strategies, as well as to examine the interrelationships between their attitudes and the perceived use of the strategies. The research was conducted by using a questionnaire on a sample of 47 respondents, and the results showed a significantly developed awareness of students about the usefulness of vocabulary learning strategies, which does not fully correspond to the recorded patterns of using the strategies. It was observed that students use social strategies the least, while they most often use determination and memorisation strategies, but they consider the cognitive and metacognitive types of strategies to be the most useful.
Sustainability of budget principles and procedures
Authors: Pešić Helena , Miljković Miloš
Published: December 2020

The topicality of the topic, something that has been given importance in recent years and its presence in everyday communication has stimulated its analysis. The paper will present an analysis of the sustainability of budget principles and budget procedures, using data analysis methods, by presenting and describing in detail all budget principles (principle of budget unity, completeness, accuracy, budget balance, specialization, duration, clarity and publicity) as and the procedures (budgeting, budgeting, execution and control of the budget) that the budget goes through.
Termination of the contract under FIDIC: The perspective of Bosnia and Herzegovina
Authors: Gagula Almir , Meškić Zlatan
Published: December 2020

FIDIC Forms of Contract in recent years are often used for regulation of rights and obligations of the investors and the contractors on the construction projects in Bosnia and Herzegovina, in particular in construction of the highways, railways and dams. Majority of the projects is finalized without significant disputes between the parties. However, in certain cases disputes between the parties escalate in such magnitude that one of the parties decides to terminate the contract. Due to severity of the financial consequences of the termination, it is necessary to emphasise interplay between the Laws on Obligations in Bosnia and Herzegovina and FIDIC Forms. A careful approach to the issue of the termination could prevent complicated and expensive arbitral proceedings.
Personal scope of arbitration agreements in Serbian law
Authors: Grušić Uglješa
Published: December 2020

This article deals with the personal scope of arbitration agreements in Serbian law and covers issues of terminology, applicable law, form of the arbitration agreement and determination of persons covered by the arbitration agreement. The judgments of the Supreme Court of Cassation in Prev 58/2016 and Prev 37/2018 are criticed. The article reaches two general conclusions. First, the departure from the UNCITRAL Model Law in Article 13 of the Serbian Law on Arbitration has led to unpredicted problems and an unacceptable interpretation of Article 13, according to which this provisions lays down a numerus clausus of the grounds on which an arbitration agreement can be held to be coveringnon-signatories. Second, Serbian courts have not shown that they are up to the task of establishing a favourable environment for the development of arbitration in Serbia.
Behavioral characteristic of deaf and hard of hearing students and students of typical development in the educational process
Authors: Mijatović Svetlana , Radovanović Vesna
Published: December 2020

Introduction. In addition to family, school has an irreplaceable role in the development and behavior of children, because it it is a place of social interaction between students, students and teachers, as well as other adults, which differs significantly from the interaction within immediate and extended family. Objectives. This research aimed to determine and describe the behavior of deaf and hard of hearing children and children of typical development in different school situations. Methods. The sample consisted of 52 lower elementary school students, 7 to 11 years of age, divided into two groups - group A with 26 deaf and hard of hearing students, and group B with 26 students of typical development. With regard to gender, the sample consisted of 34 (65.4%) male students and 18 (34.6%) female students. The Questionnaire for assessing the behavior of younger school children was used in this research. Results. The results of the research showed that there were statistically significant differences between deaf and hard of hearing students and students of typical development in class behavior: with regard to the place where they sat (ch2 = 19.57, df = 8, rc = .52, p = .01), and attention during lessons (ch2 = 16.70, df = 8, rc = .49, p = .03); during recess: with regard to playing (ch2 = 20.13, df = 8, rc = .52, p = .01); or with regard to authority: when they addressed teachers (ch2 = 7.06, df = 8, rc = .49, p = .03), received orders (ch2 = 27.58, df = 8, rc = .58, p = .001) and praise (ch2 = 27.84, df = 8, rc = .59, p = .001). Age, gender, school success, and the type of amplification in deaf and hard of hearing students did not prove to be factors that significantly affected student behavior. Conclusion. More extensive research on personal (degree of hearing loss, language competence), family (parent-child dyad) and social factors (inclusive and non-inclusive education), would explain some of the unknowns related to the behavior of deaf and hard of hearing students.
The significance of balneotherapy for the reduction of pain in elderly patients with the cervical syndrome
Authors: Cvijanović Jelena , Devečerski Gordana
Published: December 2020

Introduction/Aim: Neck pain is one of the most common musculoskeletal conditions, which is experienced by two thirds of world population at some stage in life. It can be associated with degenerative changes, psychosocial factors, sedentary way of life, reduced physical activity and stress. The aim of this study is to examine the significance of balneotherapy for the reduction of pain in elderly persons with moderately severe pain caused by cervical syndrome. Methods: Ten men and fifty-two women aged 61 to 80 years, who experienced a moderately severe pain caused by the cervical syndrome and who did not have contraindications for the application of balneotherapy and kinesitherapy, were included in this panel study. A Visual Analogue Scale (VAS) was used to measure the intensity of pain before and after balneotherapy and kinesitherapy. Results: There was no significant difference between men and women regarding age and propagation of cervical pain. After ten days of therapy, the pain stopped in around one-third of examinees, who experienced a moderately severe cervical pain and who used the thermal mineral bath with and without exercises. In every other examinee with the moderately severe intensity of cervical pain, this pain stopped after ten days of using thermal mineral water that reached ⅔ of the bathtub, and in one-third of examinees who used the thermal mineral pool and who exercised. A significantly better effect in pain elimination was achieved after the thermal mineral bath with water that filled ⅔ of the bathtub (p = 0.001) and the thermal mineral pool with exercises (p = 0.009) than after thermal mineral bath with water that filled ½ of the bathtub. It was not determined whether there was a significant difference regarding the reduction of cervical pain after the application of thermal mineral bath with ⅔ of water in the bathtub and after the use of the thermo-mineral pool with exercises. Conclusion: Balneotherapy takes an important place in the reduction of pain in elderly persons with a moderately severe pain caused by the cervical syndrome. However, more detailed research is needed to explore the significance of balneotherapy and kinesitherapy for the reduction of pain caused by cervical syndrome, especially if population aging is taken into consideration.
Challenges and opportunities for human geography: A few remarks
Authors: Ira Vladimír , Matlovič René
Published: December 2020

n the long-term development of human geography we can observe a tendency to combine ideas from an intradisciplinary debate and those imported from outside the discipline. It is profoundly influenced by a number of impulses from the rapidly changing world. This paper provides a brief survey of challenges for human geography setting them within the context of paradigmatic development and economic, social, cultural, environmental, political, and technological changes. It briefly focuses on the debates of human geographers what their discipline could or should study in the near future and how it could be done. Part of the paper is devoted to a few reflections of authors from the Visegrad Four countries concentrating attention to further direction of human geography. Human geography is unlikely to be characterised by a mono-paradigm dominance in the next few decades, but a discussion on how to find a common base for the integration of paradigms in geography is likely to continue. Changing hierarchical structures, significant modernization processes, as well as local, regional and global changes influencing space-time behavioural patterns of humans can be expected among the main sources of inspiration for the human geographic research.
Lichenometric curve for the southern slope of the Tatra Mountains (Slovak Tatras)
Authors: Kędzia Stanisław , Hreško Juraj , Bugár Gabriel
Published: December 2020

This paper presents the first lichenometric curve of Rhizocarpon geographicum for the southern slope of the Tatra Mts (Slovak Tatras). The curve was developed based on measurements carried out in the years 2018-2019. The curve was constructed using measurement results from 9 objects of known time of origin, situated in the Tatra Mts. at an altitude of 1,250-1,900 m a.s.l. On each of them, the diameter of the 5 largest thalli was measured. Their average diameter was assigned an age value and then the lichen factor was calculated and a classical lichenometric curve was developed, as well as a modified curve taking into account the effect of altitude on the rate of thallus growth. The lichen factor is in the range between approx. 34.5 mm/100 years at 1,900 m a.s.l. and 44 mm/100 years at 1,250 m a.s.l. No significant differences were found in the rate of thallus growth between the southern and northern slopes of the Tatra Mts.
L’insostenibile leggerezza della sostenibilità: i limiti dell’attuale ecopolitica
Authors: Capurso Isabella , Tolusso Emiliano , Marini Andrea , Bonardi Luca
Published: December 2020

‘Sustainability’ is a ubiquitous term within the political agenda worldwide. The common recognition of such concept has its roots in the Seventies and is the outcome of a cultural process which integrates the ‘limits to the (capitalistic) growth’ in its paradigm. Notwithstanding, the consistency between ‘sustainability’ as a concept and its expected contents is doubtful. A trustful approach towards the technical domain, together with the incorporation of ‘sustainability’ within the market mechanisms, have largely weakened the opportunity for the concept to be disruptive on a political level, locally and globally. The relevant distance between ‘sustainability’ as a term and its actual contents is the object of the present proposal. The underlying ambiguity of the ‘Sustainable Development Goals’ will be provided as a case-study for our critical review.
Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
Authors: Orlando Krystal Ann , Douglas Amber K , Abudu Aierken , Wang Yemin , Tessier-Cloutier Basile , Su Weiping , Peters Alec , Sherman Larry S , Moore Rayvon , Nguyen Vinh , Negri Gian Luca , Colborne Shane , Morin Gregg B , Kommoss Friedrich , Lang Jessica D , Hendricks William PD , Raupach Elizabeth A , Pirrotte Patrick , Huntsman David G , Trent Jeffrey M , Parker Joel S , Raab Jesse R , Weissman Bernard E
Published: December 2020

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays in SCCOHT tumorigenesis, we performed integrative multi-omic analyses in SCCOHT cell lines +/- BRG1 reexpression. BRG1 reexpression induced a gene and protein signature similar to an epithelial cell and gained chromatin accessibility sites correlated with other epithelial originating TCGA tumors. Gained chromatin accessibility and BRG1 recruited sites were strongly enriched for transcription-factor-binding motifs of AP-1 family members. Furthermore, AP-1 motifs were enriched at the promoters of highly upregulated epithelial genes. Using a dominant-negative AP-1 cell line, we found that both AP-1 DNA-binding activity and BRG1 reexpression are necessary for the gene and protein expression of epithelial genes. Our study demonstrates that BRG1 reexpression drives an epithelial-like gene and protein signature in SCCOHT cells that depends upon by AP-1 activity.
Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain
Authors: Allaway Kathryn C , Muñoz William , Tremblay Robin , Sherer Mia , Herron Jacob , Rudy Bernardo , Machold Robert , Fishell Gordon
Published: December 2020

The basal forebrain cholinergic system projects broadly throughout the cortex and constitutes a critical source of neuromodulation for arousal and attention. Traditionally, this system was thought to function diffusely. However, recent studies have revealed a high degree of spatiotemporal specificity in cholinergic signaling. How the organization of cholinergic afferents confers this level of precision remains unknown. Here, using intersectional genetic fate mapping, we demonstrate that cholinergic fibers within the mouse cortex exhibit remarkable laminar and regional specificity and that this is organized in accordance with cellular birthdate. Strikingly, birthdated cholinergic projections within the cortex follow an inside-out pattern of innervation. While early born cholinergic populations target deep layers, late born ones innervate superficial laminae. We also find that birthdate predicts cholinergic innervation patterns within the amygdala, hippocampus, and prefrontal cortex. Our work reveals previously unappreciated specificity within the cholinergic system and the developmental logic by which these circuits are assembled.
Memoria de la dictadura, hibridez y ambigüedad en La dimensión desconocida, de Nona Fernández
Authors: Carrasquer Luna
Published: December 2020

El presente artículo investiga la relación entre la hibridez genérica y la memoria de la dictadura en la novela La dimensión desconocida (2016) de Nona Fernández. El artículo argumenta que los géneros literarios de autoficción, docuficción y crónica facilitan la representación y la recuperación de la memoria individual y colectiva. El análisis narratológico demuestra que, alternando la ficción con los rasgos autobiográficos, documentales y cronísticos, se reconstruye la memoria individual fragmentada de la narradora, que completa sus recuerdos mediante la imaginación, y la memoria colectiva de la dictadura chilena, que se pretende ampliar y rescatar del olvido.
Wor1‐regulated ferroxidases contribute to pigment formation in opaque cells of Candida albicans
Authors: Dai Baodi , Xu Yinxing , Gao Ning , Chen Jiangye
Published: December 2020

Candida albicans is a harmless commensal resident in the human gut and a prevalent opportunistic pathogen. A key part of its commensalism and pathogenesis is its ability to switch between different morphological forms, including white‐to‐opaque switching. The Wor1 protein was previously identified as a master regulator of white‐to‐opaque switching in mating type locus (MTL) homozygous cells. The mechanisms by which the dark color of the opaque colonies is controlled and the pimpled surface of opaque cells is formed remain unknown. Candida albicans produces melanin pigment in vitro and during infection. However, the molecular mechanism underlying the regulation of melanin production is unclear. In this study, we demonstrated that ferroxidases (Fets) function as pigment multicopper oxidases and regulate the production of dark‐pigmented melanin in opaque cells. The FET genes presented distinct regulation patterns in response to different extracellular stimuli. In YPD (1% yeast extract, 2% peptone and 2% dextrose)‐rich medium, four of the five FET genes were up‐regulated by Wor1, especially at the human body temperature of 37 °C. In minimal medium with low ammonium concentrations, all five FET genes were up‐regulated by Wor1. However, at high ammonium concentrations, some FET genes were down‐regulated by Wor1. Wor1‐up‐regulated Fets contributed to dark pigment formation in opaque colonies, but not to the elongated shape of these opaque cells. Increased melanin externalization was associated with the pimpled surface of the opaque cells. Melanized C. albicans cells were more resistant to fungal clearance. Deletion of the five FET genes completely blocked melanin production in opaque cells and resulted in the generation of white elongated ‘opaque’ cells. In addition, the up‐regulated Fets are important for defense against oxidant attacks. The functional diversity of Fets may reflect the multiple strategies of C. albicans to rapidly adapt to diverse host niches.
Incorporation of citizens' opinions into the process of earthquake ruins maintenance: A case study of the Great East Japan earthquake ruins in Miyagi Prefecture
Authors: Nishisaka Ryo , Furuya Katsunori
Published: December 2020

The Great East Japan Earthquake struck in March 2011, causing a huge tsunami on the northeastern coast of Japan. In the disaster area, there has been a movement to preserve the damaged structures as earthquake ruins. In this study, the characteristics of establishing consensus were investigated by clarifying how the earthquake ruins have been preserved and removed, and how the opinions of citizens were accounted for in the process of maintaining these sites. The study focused on 21 earthquake ruins in Miyagi Prefecture, which were the closest to the epicenter. We extracted 30 elements from the earthquake ruins maintenance process and created labels for them. From these, we prepared time‐series charts and flowcharts and discussed the relation between entities and citizens' opinions regarding the maintenance process. We clarified four stages pertaining to the preserved ruins and found four types of relationships between the major opinions and treatment decisions. Furthermore, the periods following the earthquake were divided into three phases: pioneering, deliberation, and implementation. Consequently, we suggested that citizens' opinions, coupled with expert advice, could be used to help establish consensus in an incremental manner when making administrative decisions.
Probing Membrane Protein Association Using Concentration‐Dependent Number and Brightness
Authors: Paul Michael D. , Rainwater Randall , Zuo Yi , Gu Luo , Hristova Kalina
Published: December 2020

We introduce concentration‐dependent number and brightness (cdN&B), a fluorescence fluctuation technique that can be implemented on a standard confocal microscope and can report on the thermodynamics of membrane protein association in the native plasma membrane. It uses transient transfection to enable measurements of oligomer size as a function of receptor concentration over a broad range, yielding the association constant. We discuss artifacts in cdN&B that are concentration‐dependent and can distort the oligomerization curves, and we outline procedures that can correct for them. Using cdN&B, we characterize the association of neuropilin 1 (NRP1), a protein that plays a critical role in the development of the embryonic cardiovascular and nervous systems. We show that NRP1 associates into a tetramer in a concentration‐dependent manner, and we quantify the strength of the association. This work demonstrates the utility of cdN&B as a powerful tool in biophysical chemistry.
Tuning Photoinduced Electron Transfer in POM‐Bodipy Hybrids by Controlling the Environment: Experiment and Theory
Authors: Toupalas Georgios , Karlsson Joshua , Black Fiona A. , Masip‐Sánchez Albert , López Xavier , Ben M'Barek Youssef , Blanchard Sébastien , Proust Anna , Alves Sandra , Chabera Pavel , Clark Ian P. , Pullerits Tönu , Poblet Josep M. , Gibson Elizabeth A. , Izzet Guillaume
Published: December 2020

The optical and electrochemical properties of a series of polyoxometalate (POM) oxoclusters decorated with two bodipy (boron‐dipyrromethene) light‐harvesting units were examined. Evaluated here in this polyanionic donor‐acceptor system is the effect of the solvent and associated counterions on the intramolecular photoinduced electron transfer. The results show that both solvents and counterions have a major impact upon the energy of the charge‐transfer state by modifying the solvation shell around the POMs. This modification leads to a significantly shorter charge separation time in the case of smaller counterion and slower charge recombination in a less polar solvent. These results were rationalized in terms of Marcus theory and show that solvent and counterion both affect the driving force for photoinduced electron transfer and the reorganization energy. This was corroborated with theoretical investigations combining DFT and molecular dynamics simulations.
Tensile properties of cristobalite‐filled epoxy resin
Authors: Naito Keishi , Yoshida Michiyuki , Adachi Yoshihide , Kawai Katsuma , Sakurada Osamu , Yashiro Kisaragi
Published: December 2020

The effect of raising and lowering the temperature on the tensile properties of cristobalite spherical particle‐filled epoxy resin (CPTCL/EP) was investigated, and the fabrication of cristobalite fiber and its fiber‐reinforced plastic (FRP) was attempted. For the CPTCL/EP, the process of raising the temperature above the temperature at which the coefficient of thermal expansion of cristobalite suddenly changes (220°C) and then lowering the temperature to room temperature degraded the matrix and caused tensile residual stress in the matrix; however, interfacial adhesion between the matrix and filler improved. In other words, the tensile strength of CPTCL/EP was not reduced by this process, but rather improved. In contrast, the tensile strength of cristobalite fiber‐filled EP (CFIBER/EP) was significantly lower than the theoretical value owing to cracks in the fiber caused by dunting during fabrication of the fiber. Thus, the fabrication method needs to be further improved.
Electoral system, corporate political donation, and carbon emission intensity: Cross‐country evidence
Authors: Muttakin Mohammad Badrul , Mihret Dessalegn Getie , Rana Tarek
Published: December 2020

We examine the association between a country's electoral system and greenhouse gas (GHG) emission intensity of firms and explore whether this association is influenced by corporate political donation. The study draws on the neo‐pluralist theory of power in society to examine how possible corporate influence in the electoral systems relates to corporate environmental performance. Using a cross‐country panel dataset, we find that companies operating in countries using majoritarian electoral systems (MAJ), where corporations have a relatively low influence on election outcomes, are associated with lower GHG emission intensity than those in proportional electoral systems, after controlling for macro‐economic factors and variations in firm characteristics. Further, our findings show that corporate political donation positively moderates the association between MAJ and GHG emission intensity. Our results suggest that corporations are likely to utilise political donations as a component of business strategy to ease the regulatory actions of the state on companies. The results are robust to alternative variable measurements and tests of sensitivity.
Impact of human papillomaviruses (HPV) on recurrence rate and malignant progression of sinonasal papillomas
Authors: Paehler vor der Holte Anja , Fangk Inger , Glombitza Sabine , Wilkens Ludwig , Welkoborsky Hans J.
Published: December 2020

Sinonasal papillomas are characterized by their potential for frequent recurrences and malignant progression. Currently, the role of human papillomavirus (HPV) infection in sinonasal papillomas is unclear. A study was conducted to elucidate the impact of HPV infection on recurrence and malignant progression of sinonasal papillomas. One hundred and seven patients with 151 tumors could be examined. One hundred and one patients suffered from benign papilloma, mostly inverted papillomas (IP); six patients suffered from carcinomas in situ and squamous cell carcinomas (SCC) ex‐IP. Recurrent IP were more often HPV‐positive than non‐recurrent tumors (38.8% vs. 60%–65%). Low‐risk (LR) HPV infection (especially HPV 6) increased the risk of tumor recurrences (p = 0.0385 andp = 0.0556, respectively). IP and oncocytic papillomas (both lesions are known for their malignant potential) were more often high‐risk (HR) HPV‐positive (15.5% and 16.7%) than fungiform papilloma (which usually does not progress to carcinoma). CIS and SCC ex‐IP displayed higher HPV rates than benign IP (83.3% vs. 38.8%), especially higher rates of HR‐HPV (66.7% vs. 23.8%,p = 0.0415). Data from this study endorse the hypothesis that recurrence of sinonasal papillomas is promoted by LR‐HPV infection and that malignant progression of IP is promoted by HR‐HPV infection.
Efficient Incorporation of Clickable Unnatural Amino Acids Enables Rapid and Biocompatible Labeling of Proteins in Vitro and in Bacteria
Authors: Hadar Dagan , Gelkop Sigal , Vaserman Livne , Amiram Miriam
Published: December 2020

Site‐specific incorporation of unnatural amino acids (uAAs) bearing a bioorthogonal group has enabled the attachment – typically at a single site or at a few sites per protein – of chemical groups at precise locations for protein and biomaterial labeling, conjugation, and functionalization. Herein, we report the evolution of chromosomal Methanocaldococcus jannaschii tyrosyl‐tRNA synthetase (aaRS) for the alkyne‐bearing uAA, 4‐propargyloxy‐l‐phenylalanine (pPR), with ∼30‐fold increased production of green fluorescent protein containing three instances of pPR compared with a previously described M. jannaschii‐derived aaRS for pPR, when expressed from a single chromosomal copy. We show that when expressed from multicopy plasmids, the evolved aaRSs enable the production – using a genomically recoded Escherichia coli and the non‐recoded BL21 E. coli strain – of elastin‐like polypeptides (ELPs) containing multiple pPR residues in high yields. We further show that the multisite incorporation of pPR in ELPs facilitates the rapid, robust, and nontoxic fluorescent labeling of these proteins in bacteria. The evolved variants described in this work can be used to produce a variety of protein and biomaterial conjugates and to create efficient minimal tags for protein labeling.
The Perturbed Free‐Energy Landscape: Linking Ligand Binding to Biomolecular Folding
Authors: Abdelsattar Abdallah S. , Mansour Youssef , Aboul‐ela Fareed
Published: December 2020

The effects of ligand binding on biomolecular conformation are crucial in drug design, enzyme mechanisms, the regulation of gene expression, and other biological processes. Descriptive models such as “lock and key”, “induced fit”, and “conformation selection” are common ways to interpret such interactions. Another historical model, linked equilibria, proposes that the free‐energy landscape (FEL) is perturbed by the addition of ligand binding energy for the bound population of biomolecules. This principle leads to a unified, quantitative theory of ligand‐induced conformation change, building upon the FEL concept. We call the map of binding free energy over biomolecular conformational space the “binding affinity landscape” (BAL). The perturbed FEL predicts/explains ligand‐induced conformational changes conforming to all common descriptive models. We review recent experimental and computational studies that exemplify the perturbed FEL, with emphasis on RNA. This way of understanding ligand‐induced conformation dynamics motivates new experimental and theoretical approaches to ligand design, structural biology and systems biology.
Structural Manipulation of Layered TiS2 to TiS3 Nanobelts through Niobium Doping for High‐Performance Supercapacitors
Authors: Sajedi‐Moghaddam Ali , Mayorga‐Martinez Carmen C. , Vaghasiya Jayraj V. , Alduhaish Osamah , Sofer Zdenek , Pumera Martin
Published: December 2020

Unraveling the influence of incorporating transition metal elements on layered transition metal chalcogenides for energy storage application remains a challenge. Herein, niobium (Nb)‐doped layered titanium disulfide (TiS2) is applied to generate novel compounds Ti1−xNbxS2 (x=0.05, 0.1 and 0.20). Interestingly, TiS3 nanobelts are formed in the resulting materials, which is proven by systematic morphological and structural characterization. It has been found that Nb‐doped TiS2 compounds demonstrate superior electrochemical capacitive activity, reaching up to a 63.2 % increase in gravimetric capacitance in 1 M Na2SO4 electrolyte compared with that of the Nb‐free TiS2. This remarkably enhanced capacity behavior is attributed to Nb doping resulting a structural transition of Layered TiS2 to TiS3 nanobelts.
Analytical Ultracentrifugation (AUC): An Overview of the Application of Fluorescence and Absorbance AUC to the Study of Biological Macromolecules
Authors: Edwards Garrett B. , Muthurajan Uma M. , Bowerman Samuel , Luger Karolin
Published: December 2020

The biochemical and biophysical investigation of proteins, nucleic acids, and the assemblies that they form yields essential information to understand complex systems. Analytical ultracentrifugation (AUC) represents a broadly applicable and information‐rich method for investigating macromolecular characteristics such as size, shape, stoichiometry, and binding properties, all in the true solution‐state environment that is lacking in most orthogonal methods. Despite this, AUC remains underutilized relative to its capabilities and potential in the fields of biochemistry and molecular biology. Although there has been a rapid development of computing power and AUC analysis tools in this millennium, fewer advancements have occurred in development of new applications of the technique, leaving these powerful instruments underappreciated and underused in many research institutes. With AUC previously limited to absorbance and Rayleigh interference optics, the addition of fluorescence detection systems has greatly enhanced the applicability of AUC to macromolecular systems that are traditionally difficult to characterize. This overview provides a resource for novices, highlighting the potential of AUC and encouraging its use in their research, as well as for current users, who may benefit from our experience. We discuss the strengths of fluorescence‐detected AUC and demonstrate the power of even simple AUC experiments to answer practical and fundamental questions about biophysical properties of macromolecular assemblies. We address the development and utility of AUC, explore experimental design considerations, present case studies investigating properties of biological macromolecules that are of common interest to researchers, and review popular analysis approaches. © 2020 The Authors.
Offer on‐campus family housing to attract, support parenting students
Authors: McCarthy Claudine
Published: December 2020

One in five college students are actively raising children, but most of them don't have the same opportunities as nonparenting students, according to Autumn R. Green, Ph.D., a research scientist studying higher education access for student parents at the Wellesley Centers for Women at Wellesley College. That's because most colleges and universities don't offer housing that allows student parents to live with their children on campus, she explained.
COVID‐19 is the only issue that will matter in 2021
Authors: Hodges Dawn Z.
Published: December 2020

Every year, it's common to see articles in December or January talking about the issues in higher education for the coming year. For 2021, there's only one issue: COVID‐19. The pandemic is impacting every aspect of higher education, including technology, curriculum, learning, grades, COVID‐19 testing, campus safety, mental health, enrollment, mergers, closures, layoffs, and fundraising.
The students doth protest too much? Manage campus protests during pandemic
Authors: Lyerly Eric
Published: December 2020

The pandemic has created challenges for campus leadership, ranging from the profound, such as transitions to virtual learning, to the routine, such as increasing access to hand sanitizer.
Understand how to protect student privacy, public health during pandemic
Authors: Javanshir Leila , Rice David
Published: December 2020

Institutions of higher education face the difficult challenge of balancing student privacy with public health concerns presented by the COVID‐19 pandemic.
Copper‐catalyzed [3+2+1] Annulation of Anthranils with Phenylacetaldehydes: Synthesis of 8‐Acylquinolines
Authors: Shi Kai , Zhu Hao , Ren Fei , Liu Shuang , Song Yingying , Li Wei , Zou Liang‐Hua
Published: December 2020

A Cu0‐catalyzed protocol is proposed for the synthesis of 8‐acylquinolines through a [3+2+1] annulation starting from anthranils and phenylacetaldehydes. This protocol is of particular interest in preparing 8‐aldehyde quinolines, which have been hard to access so far. Both AgOTf and dioxygen played an important role in the reaction. C3‐heterocycle or phenylethylene substituted anthranils could also be employed in the reaction. An interesting esterification of aldehyde was observed.
Is short‐term antidepressant treatment effective and safe in bipolar depression? Results from an observational multicenter study
Authors: Tundo Antonio , Musetti Laura , Del Grande Claudia , de Filippis Rocco , Proietti Luca , Cambiali Erika , Franceschini Caterina , Dell'Osso Liliana
Published: December 2020

Objectives

To investigate the short‐term effectiveness and the short‐term and long‐term safety of acute antidepressant (AD) treatment of bipolar depression in a naturalistic setting.

Methods

Patients with bipolar (n = 86) or unipolar (n = 111) depression were consecutively recruited and treated with AD (combined with mood stabilizer [MS] and/or second‐generation antipsychotics in bipolar depression). Exclusion criteria were mixed depression, high mood instability, previous predominantly mixed depression (both bipolar and unipolar depression), rapid cycling course and previous switch AD‐emerging (bipolar depression).

Results

After 12 weeks of treatment, no difference was found in remission, response and improvement rates between bipolar and unipolar depression. Concerning short‐term safety, switching and suicidality did not differ significantly between the two groups, and no suicide attempt was observed. Concerning long‐term safety, patients with bipolar depression had a significant reduction of depressive and total recurrences during the year of follow‐up, compared to the year before entering the study, without significant changes in (hypo)mania and mixed depression recurrences, and suicide rates.

Conclusions

Acute AD treatment of bipolar depression is effective in the short‐term and safe in the short‐ and long‐term, when administered in combination with MSs and/or second‐generation antipsychotics, with a low risk of switch, mixed depression and cycle acceleration.
Inside Cover
Authors: Guermonprez Cyprien , Declercq Lieve , Decaux Géraldine , Grimaud Jean‐Alexis
Published: December 2020

Physical and chemical cellular stimulation combined in a unique home‐use device provides an effective and long‐lasting skin care regime for extrinsic skin aging prevention. The innovative principle relies on potentiating the effect of active ingredients contained in a topical serum with visible and near infrared photons to prevent extrinsic skin aging.

Further details can be found in the article by Cyprien Guermonprez, Lieve Declercq, Géraldine Decaux, and Jean‐Alexis Grimaud (e202000230).

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Inside Cover
Authors: Milanesi Alessio , Magni Giada , Centi Sonia , Schifino Gioacchino , Aluigi Annalisa , Khlebtsov Boris N. , Cavigli Lucia , Barucci Andrea , Khlebtsov Nikolai G. , Ratto Fulvio , Rossi Francesca , Pini Roberto
Published: December 2020

Cross‐polarised optical coherence tomography is a promising technique to reveal certain pathologic conditions in tissue. However, endoscopic devices with flexible small probes to detect diseased areas intraoperatively barely exist. We present an extension of a commercially available swept‐source OCT system. Applying a common‐path probe, the polarisation of reference and sample arm does not need to be further balanced. Due to a depolariser, the system is independent of the inputpolarisation.

Further details can be found in the article by Katharina Blessing, Judith Schirmer, Gargi Sharma, and Kanwarpal Singh. (e202000135).

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