bluuebunny/crossref_metadata_2025 huggingface dataset:
Mass production of Telenomus remus Nixon with an artificial diet and with leaves of Ricinus communis L., and its practical use in the control of the fall armyworm Spodoptera frugiperda (J.E. Smith)
Authors: Wurst Francisco Ferrer , Aguilar Jorge Salas
Published: April 2024

Mass production of Telenomus remus (Nixon) (Hymenoptera: Scelionidae) through artificial and natural diets for biological of the fall armyworm Spodoptera frugiperda (J.E.Smith) is discussed. The diet based on R. communis leaves, is less expensive since does not need high cost materials and other devices, one limitation is to produce high numbers of parasitoids related to the high need of leaves. Good effectiveness of T. remus has been recorded, when used at a rate of 6000-8000 individuals/ha/release, obtaining a high level of control and economic benefits.
Організації азербайджанської діаспори та стратегічні напрями їх діяльності
Authors: Мамедова Парвана
Published: April 2024

Влада діаспор зазвичай починається з першої хвилі еміграції, коли люди залишають свою батьківщину і осідають в інших країнах. В результаті цього розширюється спільнота людей, які зберігають свою культуру, мову, звичаї і традиції.

Протягом цього часу вважалось, що діаспорою формуються розгалужені мережі і соціальна структура. Члени діаспори часто використовують зв'язки зі своєю батьківщиною, наприклад, через благодійні організації, культурні обміни або підприємництво.

Важливою частиною становлення діаспори є її вплив на суспільно-політичну ситуацію як на батьківщині, так і в заміському проживанні. Діаспора може активно впливати на політику, зміни, освіту і культуру як у своїй батьківщині, так і за її межами. Таким чином, підтримується діаспора – це тривалий процес, який включає в себе безліч аспектів, таких як соціокультурна адаптація, збереження і передача культурної спадщини, підтримання зв'язків і мереж, активний вплив на суспільно-політичне життя.

Актуальність цієї статті обумовлена значним внеском азербайджанської діаспори в різні сфери суспільного життя, як всередині країни, так і за її межами.

Метою даного дослідження є аналіз стратегічних напрямків діяльності азербайджанської діаспори і механізмів їх застосування для зміцнення зв'язків з Батьківщиною, збереження і просування культурної спадщини, а також захисту інтересів співгромадян за кордоном. У статті розглядається роль діаспори в економічному, культурному та політичному розвитку Азербайджану, а також її вплив на суспільно-політичні процеси.

Результати дослідження. Азербайджанська діаспора виникла в різні періоди часу, починаючи з XIX століття. Вона складається з різних груп мігрантів і біженців, які покинули Азербайджан через політичні конфлікти, економічну кризу, війни та інші складні обставини.

Найбільші спільноти азербайджанської діаспори сформувалися в різні періоди і знаходяться в таких країнах, як Туреччина, Іран, Німеччина, США, Франція, Великобританія, Канада, Ізраїль, Грузія, Україна та ін.

Дана інформація дозволяє зробити висновки про величезний потенціал азербайджанської діаспори в реалізації загальнонаціональних інтересів і подальшому розвитку країни.
Політична доктрина лібертаріанства
Authors: Тетяна Гончарук-Чолач , Гурик Мирослава , Ковтун Ігор
Published: April 2024

Актуальність. Лібертаріанство, з його фокусом на особистій свободі та обмеженні влади, дійсно може бути привабливим для тих, хто цінує свою автономію. Воно надає індивідумам більше контролю над їхнім життям і стверджує, що держава повинна мінімізувати своє втручання в особисті справи. Водночас, важливо зазначити, що існує широкий спектр поглядів у межах лібертаріанства, і різні люди можуть мати різні підходи до конкретних питань.

Відтак, метою дослідження є розгляд характерних рис розвитку та впливу лібертаріанства на сучасний світ.

Результати. У статті з’ясовано основні принципи ідеології лібертаріанства, які базуються на поєднанні політичних свобод та автономії, при цьому наголошуючи на добровільних об’єднаннях, свободі виборів та індивідуалізмові. Суть цієї ідеології полягає у тому, що вона скептично  відноситься до публічної влади, але при цьому стоїть на опозиційній платформі по відношенню до існування економічної та політичної систем.

Висновки. Незважаючи на існування різноманітних шкіл лібертаріанства, які відрізняються один від одного різними поглядами щодо функцій державної та приватної влади, всі вони закликають до обмеження або розпуску соціальних інститутів. Лібертаріанство від самого свого початку в різних країнах отримувало втілення на тих чи інших ділянках життя, завдяки величезним зусиллям великої кількості активістів, діяльність яких сприяла тому, щоб світ став кращим, справедливішим, вільнішим і т.д., саме через це ідеї лібертаріанства сьогодні набирають своєї популярності. Ми підкреслюємо, що багато впливових політичних лідерів часто звертаються до ідей лібертаріанства у своїй діяльності, використовуючи їх в організації суспільно-політичного життя своїх громадян для покращення їх добробуту.
Are first responders interested in psychedelics? Assessing previous use, interest, and willingness to participate in psychedelic-assisted therapy
Authors: Brodie Sonia M. , Stunden Chelsea , Olson Jay A. , Artenie Despina Z. , Karapareddy Venugopal , D'Arcy Ryan C.N.
Published: April 2024

Background and aims

First responders such as firefighters and police officers often experience traumatic events as part of their work. As a result, they are more likely to have mental health issues such as post-traumatic stress disorder, depression, and anxiety compared to the general population. Psychedelic-assisted therapy has emerged as a promising avenue to alleviate these issues, but little is currently known about first responders' interest in, and barriers to, these treatments. Here, we aimed to document first responders' attitudes towards LSD-assisted therapy and previous use of psychoactive drugs.

Methods

We recruited 102 participants through mailing lists of first responders' unions. Respondents were typically male firefighters in western Canada; others were police officers, paramedics, and military personnel across Canada and the United States. They were asked about their attitudes towards LSD- and marijuana-assisted therapies, previous psychiatric diagnoses, psychosocial impairments, and substance use.

Results

Respondents showed higher rates of distress and illicit drug use compared to the general population. Of those who sought professional treatment, a minority reported that the treatment had helped them. The respondents were generally interested in taking part in therapy or research involving LSD or marijuana. The setting (e.g., at home vs. a clinic), therapist presence, and drug dose were commonly reported to influence this participation.

Conclusions

First responders may particularly benefit from psychedelic therapy given their high interest in psychedelic drugs and high rates of treatment-relevant disorders. Better understanding the needs of this population will help inform future clinical trials and psychedelic therapies.
A Fastidious Frugality
Authors: Henisch Bridget
Published: April 2024

A study of various heroines in the fiction of Charlotte Brontë attend to food and housekeeping -- with respect fastidiousness and attention to detail.
Functional Broth
Authors: Peterson Don
Published: April 2024

The author explores the synergies between slow cooked broths and dry-aged or wet-aged ferments. Examples include borscht, Korean haejangguk and Japanese misoshiru. The synergy produces unami.
The Lack of Evidence Regarding the Existence of Classical Roman Pasta
Authors: Arney Noah
Published: April 2024

This article examines the evidence for and against the existence of pasta in classical roman cuisine.
The Charlie Cart Project
Authors: Federman Carolyn
Published: April 2024

The author describes working with Alice Waters on food advocacy and education. The Edible Schoolyard Project, a nonprofit organization started by Waters (and still active in 2024), developed and supports the Edible Schoolyard, a 1.5-acre (1/2 hectare) organic garden and kitchen classroom at a public middle school in Berkeley, California, where students learn to plant, harvest, and prepare fresh produce as part of their academic day. Unlike any programme of its time, the Edible Schoolyard got the whole country talking about food education, and alerted many including the author to the value of using cooking as a vehicle for learning. This led to her Charlie Cart project.
Cooks and their Books
Authors: Lawrence-Francis Rhiannon
Published: April 2024

A brief survey of the Cookery Collection at the University of Leeds which is of national importance to researchers, as a prelude to a special exhibition on cookery held in 2017.
Dinner Down Under, 1874
Authors: Clarke Marcus
Published: April 2024

This is a reprint of a journalistic article by the Australian novelist Marcus Clarke that first appeared in the Melbourne Weekly Times in February 1874. It is a satirical account of a suburban dinner.
Peter Brears: Traditional Food in Cumbria
Authors: Dart Jesse
Published: April 2024

Peter Brears: Traditional Food in Cumbria: Bookcase, Carlisle, 2017: 412 pp., hardback, £20.00.
Sarah Moss: Spilling the Beans. Eating, Cooking, Reading and Writing in British Women’s Fiction, 1770–1830
Authors: Dart Jesse
Published: April 2024

Sarah Moss: Spilling the Beans. Eating, Cooking, Reading and Writing in British Women’s Fiction, 1770–1830: Manchester University Press, 2011; 202 pp., paperback; £15.99.
Colman Andrews: The British Table: A New Look at the Traditional Cooking of England, Scotland and Wales
Authors: Perkins Blake
Published: April 2024

Colman Andrews: The British Table: A New Look at the Traditional Cooking of England, Scotland and Wales: Abrams, 2016: 328 pp., hardback, £30.00.
APLICACIÓN DEL WEB SCRAPING Y EL ANÁLISIS AUTOMATIZADO A LOS MERCADOS DE DIVISAS Y DE ACCIONES
Authors: Rincón-Torres Andrey Felipe , Cortés-Cataño Carlos Felipe , Acevedo-Pabón Oscar Leonardo
Published: April 2024

Este trabajo es parte de un proyecto en el que estudiantes del semillero de investigación en Ciencia de Datos del Politécnico Grancolombiano fueron entrenados en técnicas de web scraping y modelado de datos de mercados. Los mercados elegidos fueron el de intercambio de divisas (FOREX) y el de acciones de la Bolsa de Valores de Colombia (BVC). Usando programación en lenguaje Python, y una serie de librerías especializadas, los semilleristas lograron la extracción, limpieza y consolidación de datos automática con completa exactitud, sin presentar datos faltantes. Además, los semilleristas lograron desarrollar aplicaciones que permiten el análisis automático con el propósito de recomendar estrategias de trading algorítmico. Esto último está particularmente avanzado en el caso del mercado FOREX, pues ya se ha desarrollado un algoritmo predictivo que promete generar ganancias.
Mobiliario Sostenible
Authors: Ulloa-Romero Claudia Andrea , Díaz-Avendaño Gina Paola , Garcia-Díaz Diana Marcela
Published: April 2024

La necesidad del ser humano que se encuentra cada vez más en situación de vulnerabilidad por los desastres naturales y los cambios ambientales que vive el planeta han dado origen a este proyecto que busca a través del cartón un material amigable con el medio ambiente, diseñar un sistema de refugio, descanso, privacidad y protección para momento de emergencia de corta duración, teniendo en cuenta que nuestro país está en un lugar donde existen tiempos prolongados de lluvias, se encuentra ubicado en una zona de constantes temblores, donde existe peligro de deslizamiento de tierras, inundaciones y derrumbes, se ve necesario el diseño que de un refugio que permita a diferentes familias poder refugiarse mientras son trasladadas a un lugar más estable, teniendo en cuenta esta situación y aprovechando la posibilidad que nos permite el diseño de intervenir en estos espacios donde la labor es requerida y la concientización social se hace más palpable, entendido también que al interior de este proceso creativo intervienen aspectos importantes a tener en cuenta como los factores que afectan o impactan el medio ambiente a lo largo de las distintas fases del ciclo de vida, los materiales empleados para su producción, la modularidad de sus formas para optimizar el espacio, su transporte y distribución a lo largo del país y su reutilización o disposición final como parte del ciclo sostenible.
L.E.O.
Authors: Gómez-Zuluaga Yessica Alexandra , Villada-Gil María Isabel
Published: April 2024

Este trabajo tiene como objetivo analizar la influencia de didácticas aplicadas para potenciar el deseo de saber alrededor de las habilidades: Lectura, Escritura y Oralidad (L.E.O.) en los estudiantes de los diversos programas académicos de la Institución Universitaria Politécnico Grancolombiano, durante los primeros semestres. Se concibe, desde el aprendizaje experiencial, aprendizaje basado en la resolución de problemas (ABRP). A partir, de un diseño de investigación cualitativo y se orientó desde la técnica taller de investigación y co-creación, desde un paradigma hermenéutico interpretativo; se realizaron (24) Talleres de creación, durante (4) semestres académicos (2021-2022). Los hallazgos resaltan el desarrollo de espacios dialógicos para la problematización de aspectos asociados a los procesos de enseñanza-aprendizaje en los estudiantes frente a las habilidades L.E.O. y la emergencia de generar espacios formativos permanentes y abiertos que permitan asegurar la continuidad, la autoevaluación de la estrategia y nuevos saberes profesionales relacionados con la lectura, escritura y oralidad, por medio del Semillero/Taller L.E.O.
Complicaciones postquirúrgicas de reemplazo de válvula aórtica en personas de mediana edad: una revisión exploratoria de literatura
Authors: Linares Sebastian , Agredo Johan , Camacho Juan Pablo , Cubides Angela , Carvajal Alejandro Botero
Published: April 2024

Introducción: Las Enfermedades Cardiovasculares (ECV) son la principal causa mundial de muerte, y cobran la vida de aproximadamente 18 millones de personas cada año, el 80% de ellas en países de ingresos bajos y medios . Decimos que es la intervención con mayor dificultad por su compuesto anatómico cardiaco y vascular. Su lesión sería sumamente peligrosa porque comprometería el sistema circulatorio y respiratorio, lo cual generaría un agravamiento del paciente o su fallecimiento. Por eso la OMS en el 2016 calculó el número de muertes atribuidas a enfermedades cardiovasculares para Colombia en 83.987, sumado a las complicaciones postquirúrgicas derivadas de ellas. Las causas que afectan al corazón y especialmente la válvula aórtica van desde una dificultad circulatoria hasta una falla mecánica, por lo que sabemos que cada año mueren más personas por enfermedades cardiovasculares (ECV) que por cualquier otra causa. Lo que significa la alta necesidad y demanda de una intervención quirúrgica, la cual es indispensable para salvaguardar la vida de los pacientes, por esta razón nos preguntamos ¿cuáles son las complicaciones postquirúrgicas de una cirugía de reemplazo de válvula aórtica en personas de mediana edad en el primer semestre post cirugía?
Objetivo: Identificar los tipos de complicaciones postquirúrgicas de reemplazo de válvula aórtica en personas de mediana edad en el primer semestre post cirugía
Metodología: Protocolo PRISMA para revisiones exploratorias de literatura y su extensión para revisiones exploratorias de literatura. Se evaluó la calidad metodológica con PEDro, y se extrajeron de forma independiente las características de los estudios.
Resultado: 28 estudios incluidos en la revisión, con puntuaciones entre 6 y 9, de calidad metodológica buena y excelente. Las complicaciones postquirúrgicas más frecuentes fueron: reintervención quirúrgica, hemorragias post cirugía, trombosis o tromboembolismo.
Conclusión: Las complicaciones por reemplazo de válvula aortica son frecuentes entre la población de mediana edad.
CORPORATE SOCIAL RESPONSIBILITY: BIBLIOMETRIC ANALYSIS OF SCIENTIFIC PRODUCTION IN THE FIRST TWO DECADES OF THE 21ST CENTURY
Authors: Borges Marcio Silva , Santos Luana de Oliveira
Published: April 2024

This study aims to conduct a bibliometric research on the evolution of scientific production in the field of corporate social responsibility (CSR) with a time frame from 2000 to 2023 in the Scopus database, identifying the main publications, authors, and relevance of the topic, thus contributing to the theoretical development of CSR in Brazil and Latin America. The bibliometric review used an of the quantitative approach with a descriptive scope by analyzing and mapping the scientific production on CSR through a descriptive analysis of the main publications on the topic. The research universe comprised all publications indexed in the Scopus database in the period from 2000 to 2023, which constituted the amount of 19,171 articles. This research contributes to expanding the studies on CSR, which is still in the process of development in Latin America and Brazil, where further studies on CSR are needed. The analysis results show an increase from 68 articles in 2000 to 2,432 articles in 2023.
Strategien der Bewältigung von Todesangst im Roman "Was man von hier aus sehen kann" Mariana Lekys
Authors: Garlikowska Aneta
Published: April 2024

Die Todesangst gehört zu den am meisten verbreiteten Emotionen in der heutigen Gesellschaft. Im Beitrag werden ausgewählte Aspekte der Todesangst und ihre Wahrnehmung im psychologischen und soziokulturellen Kontext angesprochen und anhand des Romans Was man von hier aus sehen kann von Mariana Leky genauer beleuchtet, wobei dem Zusammenhang zwischen magischem Denken und der Todesangst besondere Aufmerksamkeit gewidmet wird. Ziel des Beitrags ist es, die Strategien der gedanklichen Verarbeitung und der Bewältigung von Todesangst am Beispiel des analysierten Romans zu veranschaulichen.
The final opening of the heavy door
Authors: Małczyński Bartosz
Published: April 2024

This review is dedicated to the ten-volume edition of the Dzieła zebrane [Collected Works] of Tymoteusz Karpowicz, a significant Polish poet, playwright, literary and cultural scholar. It emphasises the scope and high quality of the editorial work carried out by Jan Stolarczyk in collaboration with Joanna Roszak. The text also synthetically discusses the content of the subsequent volumes published between 2011 and 2023, with a particular focus on the tenth volume Eseje, poezja, publicystyka, wywiady [Essays, Poetry, Journalism, Interviews], which concludes the complete edition.
Do “dizer” ao “mentir” - os verbos dicendi no discurso da imprensa sobre o Poder Executivo entre 2019 e 2022
Authors: Venturini Maria Cleci , Ribas Ellen Taborda
Published: April 2024

Objetiva-se, neste espaço de dizer, analisar o discurso da imprensa sobre declarações do sujeito que ocupou a Presidência da República entre 2019 e 2022, com vistas a responder à questão: como a imprensa reportou essas falas e que efeitos de sentido foram produzidos? Mobiliza-se como base metodológica a Análise de Discurso de linha francesa para trabalhar com os verbos dicendi das matérias jornalísticas, apreendendo-se mudanças no decorrer de quatro anos, à medida que os ataques à imprensa se intensificaram.
O Brasil tem um enorme passado pela frente...
Authors: Da Silva Daltoé Andréia
Published: April 2024

Partimos do 31 de março do primeiro ano de governo do ex-Presidente do Brasil, para tratar das divergências em torno da “comemoração” desta data. Diante da polêmica em torno deste caso em específico, que virou contenda jurídica, objetivamos investigar de que modo a história da Ditadura está permanentemente em disputa, o papel da grande mídia nesse processo e se estes sentidos inscrevem-se num projeto de sociedade capitalista-neoliberal que atende a interesses político-econômicos dominantes.
Como e por que a abordagem formal em multimodalidade é fundamental para o letramento computacional e transmidiático?
Authors: Barbosa Prado Jan Alyne
Published: April 2024

Resumo: Central para a abordagem formal em multimodalidade é a definição de modo semiótico, que combina três níveis interdependentes: o substrato material, as características técnicas organizadas em eixos de descrição (estrutura) e o nível da semântica do discurso. O narrador computacional mapeia regularidades formais de um artefato/situação comunicativa e demonstra a formalização de uma semântica para o discurso multimodal, a fim de construir novas hipóteses sobre a coerência do discurso em diferentes níveis de detalhe. O trabalho empreendido é situado tanto em termos de aproveitamento das tecnologias disponíveis, quanto de desenvolver maneiras de organizar dados multimodalmente complexos. O movimento metodológico é desenvolver camadas abstratas de anotação que nos permitam avançar sobre as propriedades de dados mensuráveis para interpretações e caracterizações em termos de narrativas e estratégias, sob o desafio de chegar aos significados dos padrões, em vez de apenas encontrar padrões.
A Monstruosidade na Representação da catedral em Notre-Dame de Paris: écfrases arquitetônicas
Authors: Alves de Oliveira Ambrosio Bruna , Ramazzina-Ghirardi Ana Luiza
Published: April 2024

Este artigo analisa a representação da catedral de Notre-Dame em Notre-Dame de Paris, de Victor Hugo, a partir da temática da monstruosidade (Cohen, 2000 e Gil, 2000). Para isso, adota-se a teoria da Intermidialidade, considerando a relação entre as mídias, analisadas à luz de Elleström (2017; 2021), a partir de écfrases arquitetônicas (Vieira, 2017). Dessa forma, considerando o romance como literatura gótica (REIS, 2019), busca-se identificar como a monstruosidade constitui um aspecto definidor da representação ecfrástica da catedral, uma mídia arquitetônica, na narrativa do texto literário.
Species delimitation using multiple sources of evidence from the Pinus strobiformis-Pinus ayacahuite Species Complex
Authors: Ortíz-Martínez Alfredo , Ornelas-García Claudia Patricia , Moo-Llanes David Alejandro , Piñero Daniel , Pérez de la Rosa Jorge Alberto , Peláez Pablo , Moreno-Letelier Alejandra
Published: April 2024

Background: The Trans-Mexican Volcanic Belt (TMVB) in central Mexico is characterized by peaks of high altitude and geologic instability. In this zone, Pinus strobiformis and Pinus ayacahuite form a contact zone with Pinus veitchii. The taxonomical circumscription of white pines in Central Mexico has been unstable, especially regarding the status of P. veitchii.

Questions: What are the species boundaries of the montane Mexican white pines species complex? Is Pinus veitchii a hybrid or an independently evolving lineage?

Studied species: Pinus strobiformis, Pinus veitchii and Pinus ayacahuite species complex.

Study site and dates: United States of America and Mexico from 2003 to 2022.

Methods: We performed multivariate analyses on 10 morphological characters and characterized the climatic niche divergence and the genetic differentiation using SNPs.

Results: Our results showed that P. veitchii is morphologically similar to P. strobiformis, but does not have intermediate morphological values with P. ayacahuite. The ecological niche differentiation was not significant.  Genetic analyses showed P. veitchii as an independent lineage with evidence of admixture with P. ayacahuite, suggesting a gene flow but not a hybrid origin.

Conclusions: Two of the three lines of evidence support three independent lineages. Environmental information showed niche conservatism, morphology and genetic structure showed differentiation of all three taxa, with a greater morphological similarity between P. strobiformis and P. veitchii, and genetic analyses recovered evidence of introgression, suggesting a complex demographic history in the Trans Mexican Volcanic Belt.
Plonowanie i jakość nasion łubinu żółtego oraz jego wpływ następczy w warunkach stosowania konwencjonalnej uprawy roli i wieloletnich uproszczeń uprawowych
Authors: Faligowska Agnieszka
Published: April 2024

Aim of study. The main aim of the study was to determine the influence of three soil tillage systems (conventional, reduced, and direct sowing) on the development, yield, sowing value, feed value and economic effect of yellow lupin cultivation. In addition, the research included assessment of the influence of the tillage system and diversified nitrogen fertilization on the yield of winter wheat and winter rape as well as the influence of yellow lupin as a forecrop. Material and methods. Between 2012 and 2017 field experiments were conducted at the Research Station in Złotniki, Poznań University of Life Sciences, Poland. The experiments were two-factorial trials in a split-plot design in four replications. The first factor was the soil tillage system (conventional, reduced, direct sowing). The other factor in the experiments on winter wheat and rape was nitrogen fertilization at doses of 0, 60, 120, and 180 kg N·ha−1. Summary. During the growing season the development of yellow lupin depended on the weather conditions most. There were no significant differences between the conventional and reduced tillage systems in: the plant density, LAI, the dry mass of roots and nodules, the number of flowers on the main stem and branches per plant, the number of flowers shed, the height of plants, the number of pods and seeds per plant, the seed yield and protein efficiency. Conventional tillage ensured the highest income and the lowest costs of seed production. The experiment showed that the yield of winter wheat cultivated after yellow lupin was about 1.2 t·ha−1 (19.3%) greater than the yield of winter wheat cultivated after winter rape. The optimal dose of nitrogen fertilization for winter wheat was 120 kg N·ha−1. The dose of 180 kg N·ha−1 did not increase the winter wheat yield significantly, as compared with the dose of 120 kg N·ha−1. In comparison with the conventional tillage system the reduced tillage system and direct sowing decreased the yield of winter rape by about 12.0% and 47.7%, respectively. The highest yield of winter rape was obtained after the application of 180 kg N·ha−1.
Корпоративные университеты России – 2023
Authors: Катькало Валерий , Шумкова Наталья , Волков Дмитрий
Published: April 2024

Настоящая книга является уникальным справочно-аналитическим изданием о популяции российских корпоративных университетов по состоянию на 2023 г. Его открывает ряд аналитических статей об актуальных аспектах работы корпоративных университетов. Далее представлен анализ результатов второй волны исследования становления и развития этих корпоративных университетов, проводимого с 2022 г. Высшей школой бизнеса НИУ ВШЭ, в том числе составлены портреты 51 корпоративного университета ведущих компаний и правительств субъектов Российской Федерации, ответившего на вопросы структурированной анкеты. Кроме того, в книгу включены материалы о Втором Форуме лидеров корпоративного обучения России. Данное справочно-аналитическое издание предназначено для руководителей и специалистов корпоративных университетов, функций управления персоналом компаний, руководителей и преподавателей вузов и бизнес-школ, а также для широкого круга профессиональных менеджеров и всех, кто интересуется современными концепциями и методами корпоративного обучения и развития талантов в конкурентоспособных организациях.
Development of ultra HPLC analytical method for pymetrozine residues in rice
Authors: Devaki Kayam , Paramasiva I , Sreelakshmi CH , MuraliKrishna T , KiranKumar K , Harathi PN , Venkateswarlu U , Sarada Jayalakshmi Devi R
Published: April 2024

Ultra HPLC-based analytical method analytical method was developed for the analysis of pymetrozine residues in different rice matrices. Chromatography separation was carried out in XR-ODS II: 150mm X 2.0mm, 5µm column in the mobile phase of water and methanol (60:40), and the resultant chromatograms were detected in a Photodiode Array (PDA). The retention time for pymetrozine neat standard and also matrix match standards was arrived at 4.00 min ± 0.5 min. The pymetrozine at the concentrations of 0.01, 0.05, 0.10, 0.25, 0.50, 0.75, and 1.00 µg/ml and the calibration curve of y = 2E+07x + 19188 obtained with a goodness of fit (R²) 0.995. The samples were extracted using the AOAC QuEChERS method with slight modifications. The harvest time residues for the different rice matrices were below the tolerance limit of pymetrozine. The residues of pymetrozine at 7, 15, and 30 days after the rice harvest in paddy seed, single-polished, double-polished rice, bran, and dehulled rice were not detected. From the developed analytical method, the residues of pymetrozine can be detected in different rice matrices.
Sifat Kimia, Fisik dan Sensori Kerupuk Pangsit pada Berbagai Konsentrasi Tepung Tulang Ikan Tenggiri
Authors: Disyacitta Citra , Astuti Sussi , Susilawati Susilawati , Koesoemawardani Dyah
Published: April 2024

Pengolahan tulang ikan tenggiri menjadi tepung dapat diaplikasikan pada produk pangan. Keunggulan tepung tulang ikan tenggiri adalah mengandung protein dan kalsium yang cukup tinggi. Penelitian bertujuan mengetahui sifat fisik, kimia, dan sensori kerupuk pangsit pada berbagai konsentrasi tepung tulang ikan tenggiri dan mengetahui konsentrasi tepung tulang ikan tenggiri terbaik. Analisis data menggunakan Rancangan Acak Kelompok Lengkap (RAKL) empat ulangan.  Enam taraf tepung tulang ikan tenggiri yaitu 0%, 5%, 10%, 15%, 20% dan 25%, dianalisis Anara dan uji Beda Nyata Jujur (BNJ) 5%.  Perlakuan penambahan 10% tepung tulang ikan tenggiri adalah perlakuan terbaik dengan kadar air 3,20%, kadar abu 2,55%, kadar kalsium 0,14%, daya kembang 16,38%,  tekstur renyah, warna kuning, rasa dan penerimaan keseluruhan disukai.  Hasil penelitian menunjukkan potensi tepung tulang ikan tenggiri sebagai sumber kalsium untuk meningkatkan nilai gizi kerupuk pangsit.
Adaptive Reuse of High-Rise Buildings for Housing: A Study of Istanbul Central Business District
Authors: Aydemir Ayşe Zeynep , Akın Tomris
Published: April 2024

The abrupt shift to remote work due to the Covid-19 pandemic increased vacant office spaces globally, especially in high-rent central business districts (CBDs). These vacant office spaces offer the potential for conversion into housing, addressing the shortage of affordable housing in central areas. Additionally, this topic presents a unique experimental ground for architecture students. This study focuses on the Istanbul CBD as a case study, examining the historical developments that led to a rise in office vacancy rates and housing inequality, and exploring the potential for adaptive reuse of these vacant office buildings. A key focus of this study is to underline the pedagogical value of adaptive reuse, highlighting how such projects can inspire more diverse and equitable housing models, fostering experimental and sustainable design approaches. It systematically evaluates the outcomes of a 4th-year architectural design studio that focuses on the adaptive reuse of the Tat Towers in the Istanbul CBD, a structurally vacant high-rise office building, and asks: How does the context of adaptive reuse enable a different design approach, and, potentially, new spatial norms and standards to emerge, and how might this hold a pedagogical value for architecture education? Following these questions, the article discusses how norms and standards are not only culturally but also typologically contextual, and how the students have explored how norms and standards might change, outlining new design approaches to adaptive reuse.
Stem cell exosomes in the pathophysiology of cardiovascular diseases
Authors: Rudoy Andrei S. , Moskalev Alexander V.
Published: April 2024

This study focused on the current state of the therapeutic potential of extracellular vesicles, which depends on the methods of their isolation and composition and the characteristics of the vesicular and nonvesicular components. Myocardial damage, particularly as a result of acute myocardial infarction, leads to irreversible death of cardiomyocytes and sarcomeres and ultimately to heart failure. The adult heart has limited regenerative capacity; therefore, stimulation of endogenous repair and regenerative potentials using cell therapy has potential. Moreover, the benefit from the injection of stem cells and progenitor cells into the damaged myocardium is mediated by the factors they secrete. In particular, exosomes, nanosized secreted extracellular vesicles of endosomal origin, have become key signaling organelles in intercellular communication and are currently considered key regenerative components of the secretome of stem and progenitor cells. Exosomes released from cardiac embryonic and mesenchymal stem cells, resident stem and progenitor cells (including a specific subgroup of cardiosphere cells), induced pluripotent stem cells, and cardiomyocytes isolated from these cells have cardioprotective, immunomodulatory, and reparative abilities. The use of exosomes in the targeted transport of drugs in lipid-like nanocontainers and extracellular vesicles is another promising area. Because artificial drug carriers, including liposomes and lipid-based nanoparticles, are limited by potential toxicity, immunogenicity, and inability to target specific organs, exosomes hold good promise as potential drug carriers. Compounds can be transported both inside exosomes and on their surface. Secreted extracellular vesicles, particularly exosomes, can be considered a key functional component of the secretome of stem cells and cardiogenic progenitor cells (mesenchymal stem cells, endogenous cardiac progenitor cells, cardiospheres, bone marrow embryonic stem cells, and bone marrow induced pluripotent stem cells). They have demonstrated therapeutic efficacy in preclinical models in the study of cardiovascular pathology.
Current state and prospects for the development of the domestic pharmaceutical industry
Authors: Miroshnichenko Yuri V. , Perfiliev Alexander B. , Shcherba Maria P. , Enikeeva Rimma A. , Ovchinnikov Dmitrii V. , Kostenko Natalya L. , Rodionov Evgeniy O.
Published: April 2024

The main stages of the development of the Russian medical and pharmaceutical industry in 2010 are presented in the context of the dominance of large foreign companies producing medicines and medical devices in the pharmaceutical market. This reflects the political and economic restrictive measures illegally taken against Russia by the European Union, the United States of America, and some other unfriendly countries and has influenced the dynamics of the development of the medical and pharmaceutical industry in our country. To harmonize approaches to the production and quality control of medicines, this paper presents the stages of large-scale reforms on the transition of the Russian pharmaceutical industry to standards of good manufacturing practice and the implementation of state programs aimed at modernizing the industrial segment of the pharmaceutical industry. As part of the improvement of the standardization system of medicines, the study also presents the characteristics of the XIII, XIV, and XV editions of the State Pharmacopoeia of the Russian Federation published during the study period, in the development of which employees of the Military Medical Academy named after S.M. Kirov participated. The role and purpose of the creation of the developed Pharmacopoeia of the Eurasian Economic Union, approved by the Board of the Eurasian Economic Commission, is also reflected in this paper. This article describes the phased implementation of federal target programs, state programs, and other strategic plans and measures of nonfinancial support from the state, which have significantly expanded competencies in the field of development and production of medicines and medical devices and increased their output during the period analyzed. The development of medicines and increasing their production volumes with the help of pharmaceutical clusters, which acted as the “locomotives” of the industry, and various projects in establishing the production of innovative medical products with the help of the Industrial Development Fund, which increased the investment attractiveness of these sectors of the national economic complex, played an important role. The results revealed the essence of the changes concerning the revival of the activities of industrial pharmacies, considering a personalized approach to the treatment of patients. The study also presents an assessment of the Pharmaceutical industry Development Strategy for the period up to 2030.
Application of a mixed type of optimization in the implementation of pharmaceutical development of a dosage form of eye drops based on oligohexamethyleneguanidine hydrosuccinate
Authors: Shatalov Denis O. , Akhmedova Diana A. , Ivanov Ivan S. , Kirillova Daria D. , Koroleva Yulia A. , Minenkov Dmitry S. , Kedik Stanislav A.
Published: April 2024

This study focused on the implementation of the stages of pharmaceutical development of a dosage form of eye drops based on the branched oligohexamethylene guanidine hydrosuccinate according to discrete and continuous optimization, followed by risk assessment and process validation. Experimental samples were developed, critical process and quality parameters were identified, technological characteristics were measured, parameters were normalized, a forecast was made, confirmatory experiments were conducted, the optimal composition was identified, risks in the production of eye drops were assessed, and partial validation was performed. During the implementation of the stages of pharmaceutical development of eye drops based on branched oligohexamethylene guanidine hydrosuccinate, three optimization cycles (discrete and continuous) were carried out, and the optimal ratio of active and auxiliary components was justified based on the results (branched oligohexamethylene guanidine hydrosuccinate 0.05%, polyvinyl alcohol 1%, phosphate-buffered saline 20%, sodium chloride 0.45%, and purified water up to 100%). After reviewing the technological process considering risk analysis, critical points were identified, and partial validation was performed, and the positive results verified and confirmed the optimal choice at this stage of pharmaceutical development. In general, a mixed type of optimization (discrete and continuous) can be used to implement pharmaceutical developments of eye drops based on branched oligohexamethylene guanidine hydrosuccinate, which is confirmed by a series of experiments and risk assessment, and the partial validation verified the data obtained. Thus, pharmaceutical development is a complex and time-consuming process, and limited functionality does not always allow quick identification of the optimal composition of a drug. As an effective solution for implementing the stages of pharmaceutical development, mathematical modeling methods and various types of optimization can be applied.
Experience of using alloplant biomaterial in the treatment of congenital aortic pathology
Authors: Mirolyubov Leonid M. , Nurmeev Ildar N.
Published: April 2024

The article is devoted to the analysis of the first clinical application of alloplant biomaterial in cardiac surgery for the treatment of congenital heart defects. Alloplant technology— processing of cadaver material— was developed by Professor E.R.Muldashev in the late 1970s for the needs of ophthalmic surgery and has proven itself to be the best. Taking into account the extensive positive experience in ophthalmic surgery, we jointly created an alloplant from the pulmonary artery, aorta, and then from the vena cava for use in the surgical treatment of congenital heart defects, including in children of the first year of life. The article presents the results of treatment of a small group of patients with similar diagnoses and a long follow-up period.
Dimensiones socioculturales de los efectos del abandono escolar en la situación social juvenil
Authors: Lira-Aguirre Francisco-Antonio , Cordero-Hidalgo Aixchel , Chaparro-Medina Paola-Margarita
Published: April 2024

Introducción: El presente artículo consiste en una revisión teórica sobre el abandono escolar en la Educación Media Superior y sus efectos en la situación social juvenil. Objetivo: Elaborar una revisión sistematizada de investigaciones que aborden los efectos del abandono escolar en la situación social de la población juvenil en el nivel de bachillerato. Metodología: Se realizó una sistematización bibliográfica-metodológica de investigaciones teóricas y empíricas en el campo educativo en México y otros países de Latinoamérica. A través de una matriz comparativa se contrastaron: enfoques, perspectivas teóricas, resultados, efectos, contrapuntos y distinciones. De esta manera, se categorizaron cinco dimensiones socioculturales como consecuencias del abandono escolar en las juventudes. Estas dimensiones son: económica-laboral, vulnerabilidad social, adultocentrismo, procesos delictivos y normas sociales de género. Se consideraron 86 productos de investigación. Resultados: Los resultados demuestran efectos sociales negativos en todas las dimensiones referidas, particularmente, se revelan el desempleo juvenil, la pérdida de oportunidades laborales, los rotulados sociales o estigmatizaciones, discriminación, bajas expectativas de futuro, ausencia de movilidad social, influencia de las actividades adultocéntricas, maternidad y paternidad juvenil, adscripción de los jóvenes al crimen organizado, segregación ocupacional por género, desafiliación académica, entre otras. Conclusiones: El mayor aporte de la investigación fue visibilizar los principales efectos negativos de la deserción e identificar las distintas aristas con un mayor grado de detenimiento en factores socioculturales. Resulta necesaria la reconceptualización, reinvención y transformación del nivel bachillerato, con el propósito de retener a los estudiantes en las escuelas y generar opciones formativas para la participación activa en el plano social de las juventudes en México y Latinoamérica. En la actualidad, los procesos formativos juveniles son de significativa importancia para el presente y futuro de una sociedad humanista y solidaria.
The Rubber Band Man: An Unexpected Reason for Breathing Difficulty
Authors: Vomer Rock , York Emma , Memon Sara , Pujalte George
Published: April 2024

A 73-year-old male presented to his physician with difficulty breathing. The patient described a nagging inability to take a deep breath, and his wife noted what appeared to be a mass on his back, that she believed had gotten bigger. He had a notable family history of soft tissues masses in numerous family members. Physical examination revealed non-painful, soft, and movable masses along the inferior edges of both scapulae, consistent with elastofibroma. Pulmonary function testing and cardiac evaluation revealed normal results. The masses remained stable in size across repeat Magnetic Resonance Imaging and were managed conservatively due to their non-impeding nature and lack of cosmetic concerns. This case highlights the importance of considering elastofibroma in patients with soft tissue masses, the significance of their physical symptomatology and the decision-making process involved in selecting appropriate management strategies based on individual patient characteristics and clinical presentations.
Multifaceted Regulation of Neural Stem Cell Fate in the Developing Brain
Authors: Uotsu Takanobu , Nakashima Kinichi , Nakashima Kinichi , Katada Sayako
Published: April 2024

Stem cells are the source of diverse cell types, and therefore their fate decisions are tightly regulated by multiple layers of controls in each tissue. Without a doubt, the brain is one of the most complex and highly functional tissues, as we now know more than 70 million neurons and even more non-neuronal cells are distributed across dozens of cortical areas in the mouse cerebral cortex, and a single region of cortex contains more than 40 cell types. These diverse neuronal cells emerge from initially homogeneous neural stem cells during embryonic development. In the course of differentiation, neural stem cells undergo cellular division to produce daughter cells with new cellular identities, during which epigenetic and transcriptional regulations determine their fate. Recent advances in the field of neural stem cell biology have revealed that not only epigenetic regulators and transcription factors but also specialized intracellular organelles regulate many aspects of stem cell functions and fate choices, and therefore it is timely to review the mechanisms of sophisticated changes of the properties of neural stem cells during development and how they impact the function of the daughter cells.
Achieving the unachievable: the development of a large-scale interprofessional education workshop for first-year health professional students. Developing a large-scale interprofessional education workshop
Authors: Bloomfield Jacqueline , Diggele Christie , Frotjold Astrid , Schneider Carl , Howard Rosa , Roberts Christopher , Lane Stuart
Published: April 2024

he need for interprofessional education within healthcare education is widely accepted, yet healthcare educators continue to grapple with the challenges associated with integrating authentic interprofessional learning activities within curricula. Timetabling conflicts, shortage of teaching spaces, geographical separation, the need for educator training, varying assessment needs, lack of organisational commitment, and suboptimal attitude by faculties towards Interprofessional Education, continue to be identified as barriers making it seemingly unachievable by many. We describe an introductory Interprofessional Education workshop that was successfully delivered to over 2600 first-year health students across 13 health disciplines at an Australian university, demonstrating how as a team of interprofessional educators we achieved the unachievable, successfully overcoming many of the obstacles to IPE. We outline the importance of authentic learning activities constructively aligned to learning outcomes and assessment, and the necessity of student, early facilitator, and faculty engagement, to overcome logistical and practical challenges. Finally, we discuss the changes to the workshop necessitated COVID-19, and future challenges and directions.
A Brief Introduction to Microhaplotypes and their Uses
Authors: Kidd Kenneth , Podini Daniele
Published: April 2024

Microhaplotypes are genetic markers that are short DNA sequences, typically consisting of two or more single nucleotide polymorphisms (SNPs) sufficiently close molecularly (<300 basepairs) that their alleles are inherited together from parent to child. Microhaplotypes can be considered a special class of haplotypes, “micro” because they extend for only a few dozens of basepairs, not thousands of basepairs. The advantage of microhaplotypes is that, with massively parallel sequencing of a small segment, the phase is known. Microhaps have been shown to be highly informative in demonstrating uniqueness of DNA profiles and in determining the biogeographic ancestry of an individual. Tests of biologic relationships, such as paternity tests, can be done with microhaplotypes. Deconvolution of DNA mixtures is an area in which microhaplotypes appear to be especially promising. This brief introductory review presents the scientific background for the development of microhaplotypes as a new type of genetic marker and examples of some of the recent applications.