bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergency Response Time and Its Determinants in the Quick Response Team in Surabaya, Indonesia
Authors: Fahmy Dhio Wardhana Fahmy Dhio Wardhana
Published: October 2023

Introduction: The response time in handling prehospital emergencies has not been fully optimal so that people still complain about it. Appropriate response time will reduce mortality and morbidity rates so that patient satisfaction can be met. The aim of this study was to describe the emergency response time and its determinants in the Quick Response Team (it is called “Tim Gerak Cepat”) Surabaya.
 Methods: This research was a descriptive research design with a cross sectional approach. The population of the study were all nurses in Tim Gerak Cepat (TGC) at the Integrated Command Post Surabaya totaling 126 nurses and a sample of 96 respondents were taken by purposive sampling. The variables were abilities, skills, education, emergency training, length of service, and motivation of nurses as well as the response time in handling emergencies. Collecting data using a questionnaire and presented in descriptive analytics.
 Results: The research results showed that the majority of respondents had high abilities (90.6%) and skills (93.8%). The majority of respondents had achieved a third diploma (D3) in nursing (82.3%) and had undergone basic emergency training (88.5%). Furthermore, more than half of the respondents had worked for more than 3 years (68.7%) and showed moderate motivation (51%). In general, the majority of respondents had a response time of ≤ 8 minutes (79.2%).
Conclusion: Nurses at TGC Surabaya actually have a good response time. This is supported by high capacity and skills in emergency situations, as well as educational background, including emergency training. But nurses still need to increase self-motivation. Further research can explore further what are the priority determining factors for emergency response time, especially in Surabaya as the 2nd largest city in Indonesia, in order to assist the government in making the best setting and organization at TGC Surabaya.
Tantangan Konservasi Alam Di Kalimantan Timur Di Tengah Eksploitasi Hutan, 1967-1998
Authors: Khoiruddin Muhammad
Published: October 2023

The nature conservation in East Kalimantan in 1967-1998 has been the focused of this study. After the 1967 to 1998 is the period of the massive conservation of Kalimantan natural forest, especially in the East Kalimantan that destroys natural forest extensively. The damage does not only affect the forest cover, but also threaten the habitat of various important animals. In the middle of the forest exploitation, the East Kalimantan nature conservation has been growing since the late 1970s. The objective of the research is explaining the development of East Kalimantan nature conservation area and its challenges in the vortex of forest exploitation. The historical approach is applied to compile and elaborate problems historically consisting of four stages, namely heuristics, criticism, interpretation, and historiography. The results show the New Order economic development policies significantly affect the emergence of threats to nature conservation in East Kalimantan. In the late 1970s, the growth of conservation area in the East Kalimantan natural forest was lagging due to the previous forest exploitation that ran for decade since 1967. Continuous forest exploitation since 1967 has fragmented conservation areas and created various threats that bear challenges to nature conservation efforts. The emerging threats include conflicts of flora and fauna, encroachment and tenurial conflicts, as well as illegal logging and mining.
Improving Collaborative Ability and Learning Achievement in Mathematics Through the Project-Based Learning (PjBL) Model Using Diagram Image Media for Class VI Students of SD Negeri Purwoharjo Academic Year 2021/2022
Authors: Ritartini
Published: October 2023

This research aims to improve students' collaboration skills and learning achievement in class VI mathematics, SD Negeri Purwoharjo for the 2021/2022 academic year through the application of the project-based learning (PjBL) learning model. This type of research is Classroom Action Research which was conducted over two cycles with each cycle consisting of 2 meetings. The subjects in this study were fifth-grade students at SD Negeri Purwoharjo, which consisted of 5 students. Data collection techniques in this study through observation. The study results showed an increase in students' collaboration skills, where in cycle I, an average score was obtained of 3.18 with a percentage of 79.44% and in cycle II an average value was obtained of 3.47 with a percentage of 86.81%. While the results of student learning achievement data also showed an increase, this is evident in the first cycle of students who fulfilled the Minimum Completeness Criteria obtained an average value of 60%, and in the second cycle students who fulfilled the Minimum Completeness Criteria obtained an average value of 100%. Therefore, the application of the project-based learning (PjBL) learning model can increase the collaboration abilities and learning achievements of students in mathematics class VI at SD Negeri Purwoharjo for the 2021/2022 academic year.
Improving Learning Outcomes and Motivation Theme VI Sub Theme 2 Using the Problem-Based Learning Learning Model for Grade IV Students at SD Negeri Banjarsari Samigaluh 2021/2022 Academic Year
Authors: Lestari Puji
Published: October 2023

This study aims to improve student learning outcomes and motivation by using the problem-based learning (PBL) model in theme VI, sub-theme 2 class IV of SD Negeri Banjarsari Samigaluh for the 2021/2022 academic year. This type of research is Classroom Action Research which was carried out for 2 cycles, each cycle consisting of 2 meetings. The subjects in this study were fourth-grade students at SD Negeri Banjarsari Samigaluh, totaling 8 students consisting of 6 boys and 2 girls. Data collection techniques in this study used observation and then the data were analyzed descriptively and presented in tabular form. The results obtained in this study showed a significant increase in student learning outcomes, wherein the first cycle students who met the Minimum Completeness Criteria obtained an average score of 4.5 with a percentage of 56.25% while in the second cycle of the participants students who meet the Minimum Completeness Criteria obtain a score of 7.5 with a percentage of 93.75%. In cycle I to cycle II it is known that the learning outcomes of students have increased by 36.50%. As for the observational data on students' learning motivation objects also showed a significant increase, where in cycle I an average value was obtained of 3.6 with a percentage of 71.19% and in cycle II an average value was obtained of 4.3 with a percentage of 85.20%. This shows that from cycle I to cycle II, students' learning motivation increased by 14.01%. Therefore, it can be concluded that the application of the problem-based learning (PBL) learning model to theme VI, sub-theme 2 can improve the learning outcomes and motivation of fourth-grade students at SD Negeri Banjarsari Samigaluh in the 2021/2022 academic year.
Self-Worth of Social-Political Activists: Theoretical Framework and Systematic Review
Authors: Jusfayana Yuthika , Hudiyana Joevarian
Published: October 2023

Activists are dedicated individuals who endeavor to create a substantial and significant influence on pivotal social issues. Their endeavors are propelled by a multitude of diverse factors, including aspects such as social identity, perceptions of fairness, efficacy, and other relevant considerations. These factors lead them to engage in a process of internalization within the collective group they are part of, shaping their sense of self-worth. However, the motivation to achieve self-worth is not always the predominant focus in existing study. Therefore, this study aimed to explained the context of activists’ self-worth through the framework of the Quest for Significance (QFS) theory, employing a systematic literature review method. The systematic literature review follows the Preferred Reporting Items for Systematic and Meta-analysis (PRISMA) protocol, utilizing keywords such as “political activism,” “personal significance,” “fulfilling life activism,” “meaningful activist,” and “activist experience.” The platforms searched include Google Scholar, Springer Nature, Taylor & Francis, and Sage Journal. During the screening stage, journals that met the criteria related to social-political activism and the activation processes of the QFS (significance gain and significance loss) were carefully selected. The study identified key theme concerning the self-worth of activists, such as the role of activism as a coping mechanism, the positive outcomes of activism, the impact of relationships on activist, and challenges inherent in activism.
A Cancer-Specific Monoclonal Antibody against HER2 for Breast Cancers
Authors: Suzuki Hiroyuki , Kaneko Mika K , Kato Yukinari
Published: October 2023

Overexpression of human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers is an important target for monoclonal antibody (mAb) therapy such as trastuzumab. All therapeutic mAbs, including anti-HER2 mAbs, exhibit adverse effects probably due to the recognition of antigens expressed in normal cells. Therefore, tumor-selective or specific mAbs have been desired to reduce adverse effects. In this study, we provide a strategy for the selection of cancer-specific mAb against HER2. We screened more than 200 of anti-HER2 mAbs obtained by our laboratory and established a novel cancer-specific anti-HER2 antibody, H2Mab-250 (IgG1, kappa). H2Mab-250 reacted with HER2-positive breast cancer BT-474 and SK-BR-3 cells. Importantly, H2Mab-250 never showed reactivity to non-transformed normal epithelial cells (HaCaT and MCF 10A) and immortalized normal epithelial cells in flow cytometry. In contrast, most anti-HER2 mAbs including H2Mab-119 (IgG1, kappa) reacted with both cancer and normal epithelial cells. The epitope mapping revealed that H2Mab-250 recognized the domain VI of HER2 and the Trp614 mainly contributes to the recognition by H2Mab-250. In immunohistochemical analysis, H2Mab-250 exhibited a superior reactivity to HER2-positive breast cancer section compared to H2Mab-119. Importantly, H2Mab-250 never showed any reactivity to normal tissues by immunohistochemical analysis. The strategy to select cancer-specific mAbs would contribute to the development of novel antibodies and modalities for cancer therapy.
Quantification of hs-Troponin Level and Global Longitudinal Strain among Critical COVID-19 Patients with Myocardial Involvement
Authors: Alsagaff Mochamad Yusuf , Kusuma  Wardhani Louisa Fadjri , Nugraha Ricardo Adrian , Putra Tony Santoso , Khrisna Bagus Putra Dharma , Al-Farabi Makhyan Jibril , Gunadi Ruth Irena , Azmi Yusuf , Budianto Christian Pramudita , Fagi Rosi Amrilla , Luthfah Nadya , Subagjo Agus , Oktaviono Yudi Her , Lefi Achmad , Dharmadjati Budi Baktijasa , Pikir Budi Susetyo , Alkaff Firas Farisi
Published: October 2023

Myocardial involvement among critical patients with coronavirus disease 2019 (COVID-19) has a worse outcome. The occurrence of an imbalance in oxygen supply results in the release of pro-inflammatory cytokines which leads to increased ventilation support requirement and increase risk of mortality. Our aim was to evaluate the association between hs-Troponin I level and global longitudinal strain as evidence of myocardial involvement among critical COVID-19 patients. Methods. We performed prospective cohort study from February 1st – July 31st, 2021 at Dr. Soetomo General Hospital, Surabaya as referral center for COVID-19 care. Of the 65 critical COVID-19 included, 41 (63.1%) were men, with a median (interquartile range) age of 51.0 years (20.0-75.0).Subjects were recruited according to WHO criteria for severe COVID-19 and CDC criteria for myocarditis. All subjects recruited were examined using echocardiography to measure global longitudinal strain (GLS) and blood samples were taken to measure hs-Troponin. Subjects were then followed to assess their needs for mechanical ventilation and in-hospital mortality. Severe COVID-19 subjects with cardiac injury were associated with an increased need for intubation (78.5%) and an increased incidence of myocarditis (50.8%). There was an association between the use of intubation and the risk of mortality in patients (66.7% vs. 33.3%, p-value <0.001). Both reduced GLS and increased hs-troponin are associated with increased myocarditis (p-value <0.001 and 0.004 respectively). Reduced GLS is associated with higher mechanical ventilation needs (12.17 + 4.79 vs.15.65 + 4.90, p-value 0.02) and a higher mortality rate (11.36 + 4.64 vs. 14.74 + 4.82; p-value 0.005). Increased hs-troponin is associated with higher mechanical ventilation needs (25.33% vs. 3.56%, p-value 0.002) and a higher mortality rate (34.57% vs. 5.76%, p-value 0.002). Compared with contemporary controls, critical COVID-19 patients with myocardial involvement and elevated cardiac troponin level are associated with higher mechanical ventilation needs and a higher mortality rate.
Antiviral Efficacy of Heparan Sulfate and Enoxaparin Sodium against SARS-CoV-2: An In-Vitro/in-Silico Model
Authors: Fuochi Virginia , Furnari Salvatore , Floresta Giuseppe , Patamia Vincenzo , Zagni Chiara , Drago Filippo , Rescifina Antonio , Furneri Pio Maria
Published: October 2023

SARS-CoV-2 attachment and entry inside mammalian cells is mainly mediated by human angiotensin-converting enzyme 2 (ACE2) and its interaction with spike protein. However, it is well known that spike protein also interacts with other molecules like glycosaminoglycans (GAG), e.g., heparan sulfate (HS) or Enoxaparin (EX), which are linear, anionically charged polysaccharides known for their biological activities. The mode of action of these two polysaccharides is to bind spike protein to block the interaction with ACE2 receptors. This study aimed to assess a model capable of confirming the activity of these GAGs in both the wild-type strain of SARS-CoV-2 and its variants, such as the highly variable BA.2.86. This was achieved by combining in silico modeling with in vitro determination using BacMam technology. The results showed the antiviral activity of HS and EX both in vitro and through the in-silico analysis, reconciling conflicting findings from recent studies on the cellular entry of SARS-CoV-2. In conclusion, it is possible to highlight the ability of these molecules to circumvent the high variability of SARS-CoV-2, providing valuable insights into intervention strategies targeting cell entry mechanisms and establishing a safe in vitro model.
Assessing the Tourism City from an ES Perspective: The Evaluation of Tourism Service in Liyang, China
Authors: Fan Xiangnan , Cheng Yuning
Published: October 2023

Tourism is an important industry that promotes national economic and social progress. All-for-one tourism is a new concept of regionally coordinated development that uses the tourism industry as an engine to boost resource integration, industrial integration, and social sharing. Tourism service is the main embodiment of cultural ecosystem services for all-for-one tourism cities. Taking Liyang in China as an example, this paper used a combination of GIS spatial analysis and big data text mining to evaluate the tourism service from three aspects: the quality of tourism resources, the comprehensiveness of tourism service facilities, and the satisfaction of tourists. The results show that (1) the tourism service is better in the northwestern and eastern areas of the city, while it is lower in the northeastern and southwestern parts; (2) the hotspot areas should focus on improving the tour routes, the transport capacity, and excessive charges; the cold spot areas should work on ecological restoration and creating new tourism attractions by combining the local industries; (3) rural tourism integrating agriculture and visitation should be highlighted as a key growth point to improve the city’s tourism service function.
Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders Through the Gut-Brain Axis
Authors: Liwinski Timur , Lang Undine E. , Brühl Annette B. , Schneider Else
Published: October 2023

Research conducted on individuals with depression reveals that major depressive disorders (MDDs) coincide with diminished levels of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the brain, as well as modifications in the subunit composition of the primary receptors (GABAA receptors) responsible for mediating GABAergic inhibition. Furthermore, there is substantial evidence supporting the significant role of GABA in regulating stress within the brain, which is a pivotal vulnerability factor in mood disorders. Although there is substantial evidence indicating that GABA may be affecting GABA receptors in peripheral tissues, there is comparatively less evidence supporting its direct action within the brain. Emerging evidence highlights that GABA may exert beneficial effects on the brain and psyche through the gut-brain axis. GABA is readily available and approved as a food supplement in many countries. While GABA enjoys wide consumer acceptance in Eastern Asian markets, with many consumers reporting favorable effects on stress regulation, mood, and sleep, rigorous independent research is still largely lacking. Basic research, coupled with initial clinical findings, makes GABA an intriguing neuro-nutritional compound deserving of clinical studies in individuals with depression and other psychological problems.
Assessing the Impact and Sustainability of Community Development Initiatives in Awgbu, Anambra State (2015-2023)
Authors: CHUKWUDI CELESTINA EKENE , Owoh Emeka Emmanuel
Published: October 2023

This study assesses the impact and sustainability of community development initiatives in Awgbu, Anambra State, spanning from 2015 to 2023. Using qualitative research methods, including interviews with key informants from the Awgbu community and government personnel. The observatory method is also applied which helped the researcher to see activities executed in the community. The research investigates the specific contributions of the Awgbu community to the overall development of Anambra State, how the community has benefitted from state government initiatives, and the extent to which the community responds to government requests and initiatives. The study also explores challenges in the relationship between the state government and Awgbu in terms of community development initiatives and offers recommendations for enhancing this relationship. The findings reveal that the Awgbu community has made significant contributions to the development of Anambra State, particularly in areas such as security, education, and infrastructure. The community has actively responded to government calls, participating in initiatives like the Choose Your Project Initiative (CYPI) and vigilante groups, thus fostering a positive and mutually beneficial relationship with the state government. However, challenges such as leadership crises and communication gaps exist, hindering the community's progress. Recommendations include improving community leadership, enhancing communication, and promoting peace to ensure sustainable community development. This research contributes to a deeper understanding of the dynamics between communities and government in achieving sustainable development and highlights the importance of collaborative efforts for positive outcomes. The findings have managerial and policy implications for both local communities and governments seeking to enhance community development initiatives and foster mutually beneficial relationships.
Continuous Super-Resolution of Climate Data Using Time-aware Implicit Neural Representation
Authors: Wang Yang , Karimi Hassan A. , Jia Xiaowei
Published: October 2023

Accurate climate data at fine spatial resolution are essential for scientific research and the development and planning of crucial social systems, such as energy and agriculture. Among them, sea surface temperature plays a critical role as the associated El Niño-Southern Oscillation (ENSO) is considered a significant signal of global interannual climate system. In this paper, we propose an implicit neural representation-based interpolation method with temporal information (T_INRI) to reconstruct climate data of high spatial resolution, with sea surface temperature as the research object. Traditional deep learning models for generating high-resolution climate data are only applicable to fixed resolution enhancement scales. In contrast, the proposed T_INRI method is not limited to the enhancement scale provided during the training process and its results indicate that it can enhance low-resolution input by arbitrary scale. Additionally, we discuss the impact of temporal information on the generation of high-resolution climate data, specifically, which month the low-resolution sea surface temperature data is from. Our experimental results indicate that T_INRI is advantageous over traditional interpolation methods under different enhancement scales, and the temporal information can improve T_INRI performance for a different calendar month. We also examined the potential capability of T_INRI in recovering missing grid value. These results demonstrate that the proposed T_INRI is a promising method for generating high-resolution climate data and has significant implications for climate research and related applications.
Frost Heaving Behavior and Enhancement Approaches of Cement-Based Grout Materials under Freeze-Thaw Conditions
Authors: Wei Yongfeng , Dou Hui , Gao Jiangtao , Su Run , Ma Shengjun
Published: October 2023

In the seasonally frozen regions, during the grouting of prestressed bridge ducts in low-temperature environments, incompletely cured grout materials undergo volumetric changes due to the freeze-thaw cycling, resulting in structural cracks along the prestressing ducts of the bridge, thereby diminishing the bridge's operational lifespan. To investigate the frost heaving characteristics of grout materials under freeze-thaw cycles and propose potential enhancements, this study was devised to conduct frost heaving stress tests on grout materials. Through this research, we gained insights into how various additives affect the frost heaving stress characteristics of grout materials under freeze-thaw cycles. Incorporating analyses of free water content, setting time, compressive strength, as well as macroscopic examinations such as XRD and SEM, this study delves into the mechanisms for enhancing frost heaving characteristics of grout materials. Furthermore, it proposes a research approach that utilizes multiple admixtures to improve the frost heaving properties of grout materials. Through frost heaving stress tests and other macroscopic experiments, the study investigates the influence of these combined admixtures on frost heaving stress in grout materials and elucidates the underlying improvement mechanisms. The results indicate that reducing the water-cement ratio, incorporating calcium formate, sulfoaluminate cement, air-entraining agents, and carbamide all have a positive impact on mitigating frost heaving stress in grout materials. However, the improvement mechanisms differ, and employing a single measure alone is insufficient to effectively reduce frost heaving stress while meeting performance criteria such as compressive strength, setting time, and flowability. Free water content emerges as a crucial indicator determining the magnitude of frost heaving stress in grout materials, with 11.5% of free water content representing the critical threshold for frost heaving in grout materials. Utilizing composite admixtures can simultaneously decrease free water content, lower the freezing point of free water, and alleviate frost heaving deformation, resulting in more efficient reduction of frost heaving stress. When the admixture content reaches 9.9%, frost heaving stress is eliminated, and the comprehensive performance parameters including compressive strength, setting time, and flowability meet the specified requirements.
355 nm Nanosecond Ultraviolet Pulsed Laser Annealing Effects on Amorphous In-Ga-ZnO Thin Film Transistors
Authors: Park Sang Yeon , Choi Younggon , Seo Yong Hyeok , Kim Hojun , Lee Dong Hyun , Truong Phuoc Loc , Jeon Yongmin , Yoo Hocheon , Kwon Sang Jik , Lee Daeho , Cho Eou-Sik
Published: October 2023

An ultraviolet (UV) nanosecond pulsed laser with a wavelength of 355 nm was applied to anneal amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFT) at various laser beam powers ranging from 0 to 280 mW. Laser irradiation was selectively carried out on the a-IGZO channel area using the beam scanning method after the a-IGZO TFT was formed through indium-tin oxide (ITO) electrode patterning and a subsequent lift-off process. After laser annealing, negative shifts in the threshold voltages and enhanced on-currents were observed at laser-beam powers ranging from 54 to 120 mW. No meaningful parameters were investigated for laser beams higher than 200 mW. By extracting the energy band gap and work function of a-IGZO from the transmittance and ultraviolet photoelectron spectroscopy (UPS) results, the ITO electrode/a-IGZO channel energy band structures were established under different laser annealing conditions, and the electron injection mechanism from the ITO to the a-IGZO channel was analyzed and optimized at a laser beam power of 120 mW. The results show that the electrical characteristics of the a-IGZO TFTs can be improved without any heat damage to the substrate because of the selective annealing process.
Fatigue Analysis on Wheels with Finite Element Method using Solidworks Software
Authors: Nasrullah Hamid , Yuvenda Dori , Efendi Adhan , Jatmoko Dwi , Hasiffurozi Hasiffurozi
Published: October 2023

Most of the damage to Vleg cars was caused by material fatigue. The objectives of the fatigue analysis on Xenia 2011 car wheels with the Finite Element Method using Solidworks are: 1) Knowing the fatigue analysis process on car wheels, 2) Knowing the results of the fatigue analysis on car wheels. The research method used is the Finite Element Method (FEM) method; the re-search steps include model data retrieval from the Wheel code, 3D model creation process, static simulation process according to SAE J 328 standard, mesh variations, fatigue simulation, and finally, standardization of results fatigue simulation regarding the SAE J 328 standard. The re-sults of the fatigue analysis on the Xenia 2011 car wheels obtained an age of 1000,000 cycles when compared with the minimum average of SAE J 328 of 600,000 cycles, this product design is clas-sified as a high cycle, which means it will experience a prolonged failure, and this design has a maximum alternating stress value of 627.4702 MPa, a strain of 0.007105, a displacement of 7.148 mm and a SOF of 0.087890 with a load factor used of 2.5, so overall this Xenia car can be loaded with a load of 1775 kg, if it is more than that, then Wheels will experience cracking.
Processing Accuracy of Microwave Photonic Signal Processors Based on Microcombs as a Function of Different Input Signal Waveforms
Authors: Moss David
Published: October 2023

Microwave photonic (MWP) signal processors, which process microwave signals based on photonic technologies, bring advantages intrinsic to photonics such as low loss, large processing bandwidth, and strong immunity to electromagnetic interference. Optical microcombs can offer a large number of wavelength channels and compact device footprints, which make them powerful multi-wavelength sources for MWP signal processors to realize a variety of processing functions. In this paper, we experimentally demonstrate the capability of microcomb-based MWP signal processors to handle diverse input signal waveforms. In addition, we quantify the processing accuracy for different input signal waveforms, including Gaussian, triangle, parabolic, super Gaussian, and nearly square waveforms. Finally, we analyze the factors contributing to the difference in the processing accuracy among the different input waveforms, and our theoretical analysis well elucidates the experimental results. These results provide a guidance for microcomb-based MWP signal processors when processing microwave signals of various waveforms.
PREDICTING THE RISK OF ADVERSE OUTCOME AMONG PATIENTS WITH COVID-19 HOSPITALIZED IN AN INFECTIOUS DISEASE HOSPITAL
Authors:   Astrakhan State Medical University, KALASHNIKOV EVGENY S. , SERDYUKOV ANATOLY G. ,   Astrakhan State Medical University, POLUNINA EKATERINA A. ,   Astrakhan State Medical University
Published: October 2023

Introduction. The identification of predictors of mortality in COVID-19 remains one of the primary directions among all studies devoted to this topic. The search and selection of the most sensitive prognostic tools is the basis for improving the prognosis in patients with COVID-19 and for the proper allocation of health resources. Aim. The aim is to develop a prognostic model for assessing the risk of an adverse outcome in the first two days in patients with COVID-19 hospitalized in an infectious diseases hospital. Material and Methods: the clinical and anamnestic data of 148 patients with an unfavorable (fatal) outcome in the first two days after hospitalization and 364 patients with a favorable outcome up to 10 bed days were analyzed. Statistical analysis was carried out using the StatTech v. 2.8.8 program (developed by Stattech OOO, Russia). Results and discussion. According to the results of our study, the following predictors were included in the prognostic model: age, male gender, degree of respiratory failure, type 2 diabetes mellitus, obesity, arterial hypertension and coronary heart disease. Under the influence of a set of predictors, the risk of an unfavorable outcome in patients with COVID-19 increased in male patients by 1.1 times, with an increase in age by 1 year by 1.1 times, in the presence of grade 2 respiratory failure by 5.9 times, grade 3 respiratory failure by 17.4 times, type 2 diabetes by 1.1 times, obesity by 1.4 times, arterial hypertension by 1.8 times, coronary heart disease by 3.7 times. Conclusion. The obtained prognostic model for assessing the risk of an adverse outcome in patients with COVID-19 has good prognostic abilities, its sensitivity and specificity were 76.5% and 77.8%, respectively. The resulting model can help optimize the prediction of outcome in hospitalized patients with COVID-19
SPA AND RESORT POSSIBILITIES IN REPRODUCTIVE HEALTH RECOVERY IN PATIENTS WITH EARLY GESTATIONAL LOSSES
Authors:   Altai State Medical University, YAVORSKAYA SVETLANA D. , REMNEVA OLGA V. ,   Altai State Medical University, CHERNOVA ANASTASIYA E. ,   Altai State Medical University, DMITRIENKO KSENIYA V. ,   Altai State Medical University, PETROV ANDREY V. ,   Spa and Resort «Altai Castle»? Altai Region, GREBTSOV IVAN V. ,   Altai Regional Oncological Hospital
Published: October 2023

Introduction. Early pregnancy loss is still an unresolved problem in obstetric and gynecology. The pathogenesis is based on the comorbidity of pathological factors such as subclinical hormonal, immune, psychoneurotic disorders and endometrial pathology. It requires complex rehabilitation pregnancy planning programs for such patients. Aim. Aim of research is to optimize treatment and rehabilitation measures in patients with the history of early pregnancy lost using the Belokurikha’s spa and resort clusters. Material and methods. 79 patients with early reproductive lost history underwent a course of medical and rehabilitation treatment in the «Altai Castle» spa and resort (Belokurikha, Altai Region). Complex spa treatment included climatotherapy and combination of various methods: balneo-, peloid-, physiotherapy and a prolonged course of herbal medicine. Results and discussion. Women with a history of early pregnancy loss had significant improvement in physical and mental health, ultrasound chronic endometritis markers were decreased. The first year onset pregnancy occurred in 70.9% after rehabilitation and most of them (92.8%) delivered at term. Proposed rehabilitation program is highly efficient due to the multidirectional potentiating action of natural factors that have powerful immunomodulatory, anti-inflammatory and regenerating effects. Conclusion. A complex rehabilitation program for patients with a history of early pregnancy lost in Belokurikha’s spa and resort with a prolonged course of herbal medicine helps to make rapid psychosomatic and reproductive health recovery.
PROSPECTS FOR THE SEARCH AND DEVELOPMENT OF NEW ORIGINAL PHARMACEUTICAL SUBSTANCES - DERIVATIVES OF USNINIC ACID EXTRACTED FROM LICHENS (REVIEW)
Authors:   Northern State Medical University, KRYLOV ILYA AL. , SHERSTENNIKOV NIKOLAY V. ,   Northern State Medical University, KUBASOVA ELENA D. ,   Northern State Medical University, KORELSKAYA GALINA V. ,   Northern State Medical University, KUBASOV ROMAN V. ,   Northern State Medical University, GRZYBOWSKI ANDREY M. ,   Northern State Medical University, LENINA JULIANA AL. ,   Northern State Medical University, KARAMAN SERGEY AL. ,   Northern State Medical University
Published: October 2023

Relevance: scientific and practical interest in usninic acid and its derivatives is increasing every year. This is due to their rather high biological activity, effectiveness in the treatment of many pathological conditions. In addition, usninic acid is contained in significant volumes in plant raw materials, primarily in ubiquitous lichens. The process of its extraction from plants is relatively simple and economically favorable. The purpose of the work was to conduct a narrative review of the prospects for the practical (pharmaceutical) use of usninic acid. Materials for research. For literature analysis, we performed search from the international databases Web of Science, Scopus, PubMed, as well as the domestic library system eLibrary. Results. Usnic acid in certain doses and combinations with other components has a toxic effect. These properties can be widely used in the treatment of infectious diseases (which is relevant due to the increasing resistance of microorganisms to drugs). Cytotoxic and genotoxic effects can be purposefully applied in the treatment of oncological neoplasms. The positive results of experimental studies, both in vitro and in vivo, proved the prospects for the development of new original pharmaceutical substances based on usninic acid derivatives obtained from lichens. It is concluded that lichens can be considered a unique natural supplier of biologically active components, primarily usninic acid. Its use is warranted for therapeutic and prophylactic purposes and requires the search and development of new pharmacological agents.
Effect of government role and human resource competence on level of success of small and medium enterprises in East Java province with business performance as mediation variable
Authors: Al Idrus Salim , Abdussakir Abdussakir , Al Idrus Shofiyah , Supriyanto Achmad Sani , Ahmar Ansari Saleh , Kamaluddin Kamaluddin
Published: October 2023

The objective of this research is to reveal the effect of government role and human resource competence on level of success of SMEs in East Java Province with business performance as mediation variable. Using quantitative research, causal relationship across variables is ensured through SEM-PLS method. Sampling technique is purposive random sampling with 130 SMEs used as sample. Data collection technique is using questionnaire. The results of research show that government role and human resource competence affect level of success of SMEs in East Java Province; and business performance is the mediation variable to the effect of government role and human resource competence on level of success of SMEs in East Java Province.
Pengaruh tingkat kewaspadaan terhadap konservatisme akuntansi
Authors: Koeswanto Michelle Angeline , Feliana Yie Ke , Eriandani Rizky
Published: October 2023

Penerapan konservatisme dalam pelaporan keuangan berperan penting bagi badan usaha dalam menghadapi ketidakpastian di lingkungan bisnis yang dinamis. Penelitian ini bertujuan untuk mengetahui pengaruh ketidakpastian lingkungan bisnis berdasarkan tingkat kewaspadaan terhadap konservatisme akuntansi. Tingkat kewaspadaan dibedakan menjadi dua, yaitu alert dan inert. Penelitian menggunakan 849 sampel badan usaha sektor non-keuangan yang terdaftar di BEI periode 2019-2021. Pengolahan data menggunakan moderated regression analysis. Hasil penelitian menunjukkan bahwa perusahaan alert atau perusahaan dengan ketidakpastian lingkungan bisnis yang tinggi justru kurang konservatif. Sebaliknya, inert dengan tingkat ketidakpastian lingkungan rendah lebih konservatif. Perusahaan alert dengan kesiapan menghadapi perubahan kondisi cenderung lebih agresif dalam pelaporan, dan kemungkinan lebih memilih mengungkapkan faktor risiko ketidakpastian dibanding melaporkan secara konservatif. Implikasi hasil penelitian menunjukkan bahwa ketidakpastian lingkungan bisnis berdasarkan tingkat kewaspadaan berpengaruh terhadap konservatisme.
Analisis moderasi inklusi keuangan pada pengaruh platform terhadap minat penggunaan pinjaman online
Authors: Prajogo Uke , Rusno Rusno
Published: October 2023

The aim of this research is to analyze the moderation of financial inclusion on the influence of platforms on interest in using online loans. The research sample was 50 SMEs who were members of ABM Preneur using a stratified random sampling technique. The research results show that H1 is supported but H2 is not supported. So the platform has a significant positive effect on interest in using online loans. However, financial inclusion does not moderate the influence of the platform on interest in using online loans.
Investment decision analysis on sustainable renewable energy policy: Literature review
Authors: Maria Maria Magdalena Bate'e , Fachruddin Khaira Amalia
Published: October 2023

This paper discusses sustainable renewable energy policies. The method used in this paper is a descriptive method that collects data from various sources literature studies and previous research. The results of the literature review show that the development of renewable energy in the European Union has three clusters dividing the share of renewable energy and the degree of dependency on energy imports based on the country. In Pakistan, the government has been designing a renewable energy policy since 2006 to supply sustainable energy to all consumers. In Nigeria, the electricity crisis and the need to reduce greenhouse gases spurred the development of renewable energy. Denmark has moved to wind power sources by increasing the share of renewable energy in the domestic electricity supply. The government encourages local ownership in the renewable energy sector, and many neighborhoods are connected to district heating systems that use renewable energy such as biomass. Increased investment in renewable energy technology will aid in addressing global energy concerns and hastening the transition to a low-carbon economy.
Literature study of millennial leadership concepts to find new perspectives on leadership styles
Authors: Kusumawati Berlianingsih , Masduki Uki , Utami Sulistyo Seti , Dahlan Dede , Maryama Siti
Published: October 2023

The leadership style was born driven by the assumption that the previous leadership style is no longer relevant if applied to today's millennial generation. This research is the first step to discovering millennial leadership styles that are difficult to find in previous literature. This study will use the literature review methodology to identify a range of theories that are pertinent to the issue under study. Data obtained from the Proquest and Google Scholar databases. The keywords leadership, leadership, leadership style, and millennial worker are used. We'll take the relevant article and analyze it, the article written between 2010–2022. This study find indicators of millennial leadership style based on the needs and characteristics of the millennial generation. There are eighteen indicators of millennial leadership style based on studies.
Çok Boyutlu Ölçekleme Analizi ile Avrupa Birliği Ülkelerinin ve Türkiye’nin Sürdürülebilir Kalkınma Düzeylerinin Karşılaştırılması
Authors: VEYSİKARANİ Dilek
Published: October 2023

Sürdürülebilir kalkınma, beşerî ve ekonomik gelişmeler, siyasi yapılar, nüfus ve refah seviyesi gibi önemli kalemler arasındaki ilişkilere yönelik farkındalığa çözüm olmak için oluşturulmuş bir kavramdır. Bertelsmann Stiftung ve Sürdürülebilir Kalkınma Çözümleri Ağı’nın her yıl düzenli olarak hazırlayıp yayınladığı Sürdürülebilir Kalkınma Hedefleri Raporu, devletlerin sürdürülebilir kalkınma hedeflerine ulaşmak ve mevcut düzeylerini değerlendirmek için yapılan bir araştırmadır. İlgili araştırma raporu, 2030 yılına kadar ülkelerin, gerçekleştirmeleri öngörülen sürdürülebilir kalkınma hedeflerinde öncelik olarak hangi sorunu yer vermeleri konusunda bilgi vermektedir. Bu doğrultuda çalışmanın temel amacı 17 hedeften oluşan Sürdürülebilir Kalkınma Hedefleri Endeksi’nin teorik olarak incelenmesi ve Covid-19 salgınından önce ve sonra meydana gelen değişimlerin istatistiksel yöntemler ile değerlendirilmesidir. Çalışmada, Çok Boyutlu Ölçekleme Analizi kullanılarak Avrupa Birliği üyesi ülkeler ve Türkiye için hesaplama yapılmıştır. Analizde, Covid-19 pandemisi öncesi için 2019 yılı verileri, Covid-19 pandemisi sonrası 2022 yılı verileri kullanılmıştır. Araştırmada hem ülkeler hem de sürdürülebilir kalkınma hedefleri endeksine ait olan değişkenler benzerliklerine göre ayrı ayrı incelenmiştir. Değişkenler arasında en belirgin olarak öne çıkan hedefler yoksulluk ile savaşma, kaliteli yaşam ve toplumsal cinsiyet eşitliği gibi sosyo-ekonomik hedefler olmuştur. Ülkeler arasında analiz yapıldığında pandemi öncesi ve sonrasında en belirgin ve öncü olan ülkeler dünya ekonomisinde önemli yere sahip olan Avusturya, Danimarka, Finlandiya, İsveç ve Lüksemburg olarak belirlenmiştir.
100. Yılda Türk Sağlık Sistemi Deneyimleri
Authors: ÇAM Sıddıka , YELSİZ Muazzez , EKE Erdal
Published: October 2023

Sağlık sistemleri hem birey ve toplum sağlığı hem de devletlerin gelişmişlik düzeyi açısından önem arz etmektedir. Günümüzde pek çok gösterge üzerinden değerlendirilebilen sağlık sistemleri, başta örgütsel ve finansal yapısı olmak üzere çok sayıda parametre üzerinden mukayese edilebilmektedir. Cumhuriyetin ilan edilmesiyle birlikte Türk sağlık sistemi, yeniden şekillendirilmiş ve günümüze kadar günün koşullarına da bağlı olarak değişen ve dönüşen bir özelliğe sahip olmuştur. Bu noktadan yola çıkılarak kurgulanan bu çalışma, Türkiye’nin yüzüncü yılında Türk sağlık sisteminin yüz yıllık serüveninin betimlenmesini amaçlamıştır. Nitel araştırma yönteminin benimsendiği çalışmada, “Türk sağlık sistemi” fenomeninin derinlemesine incelenmesi amacıyla nitel araştırma desenlerinden fenomenoloji deseni kullanılmıştır. Bununla birlikte çalışma kapsamında doküman incelemesi ve görüşme tekniğinden faydalanılmıştır. Bu doğrultuda yönetim, örgütlenme, hizmet sunumu ve finansman boyutlarında Türk sağlık sisteminin geçmişten bugüne gelişimi ile yüz yıllık süreçteki kırılma noktaları araştırılmıştır. Çalışmada geçmişteki sağlık sitemine dair deneyimlerin aktarılabilmesi amacıyla katılımcılar belirlenirken “50 yaş ve üstü olma” kriteri benimsenmiş, bu amaçla da amaçlı örnekleme yöntemlerinden maksimum çeşitlilik örneklemesi kullanılmıştır. Çalışma sonucunda yönetim boyutu 9 alt tema, örgütlenme boyutu 4 alt tema, hizmet sunumu boyutu 8 alt tema, finansman boyutu ise 12 alt tema altında analiz edilerek Türk sağlık sisteminin 100 yıllık süreci detaylarıyla birlikte incelenmiş ve ortaya konulmuştur.
Using delta channel width to estimate paleodischarge in the rock record: geometric scaling and practical sampling criteria
Authors: Prasojo Octria Adi , van Yperen Anna E. , Hoey Trevor B. , Owen Amanda , Williams Richard
Published: October 2023

Quantifying paleodischarge from geological field observations remains a key research challenge. Several scaling relationships between paleodischarge and channel morphology (width, depth) have been developed for rivers and river deltas. Previous paleodischarge scaling relationships were based on discharge–catchment-area scaling and an empirical flow-velocity estimate (e.g., the Chézy equation, the Manning equation) multiplied by channel cross-sectional area to derive discharge. In deltas, where marine (wave, tide) energy causes bidirectional flow in distributary-channels, the available paleodischarge scaling relationships are not applicable due to their unidirectional-flow assumption. Here, the spatial variability of distributary-channel widths from a database of 114 global modern river deltas is assessed to understand the limit of marine influence on distributary-channel widths. Using measured 6,213 distributary-channel widths, the median channel widths of distributary-channels for each delta were correlated with bankfull discharge for river-, tide- and wave-dominated deltas, the latter two including the effect of bidirectional flow. Statistically significant width–discharge scaling relationships are derived for river- and wave-dominated deltas, with no significant relationships identified for tide-dominated deltas. By reverse bootstrapping the channel widths measured from modern deltas, the minimum number of width measurements needed to apply width–discharge scaling relationships to ancient deltaic deposits is estimated as 3 and 4 for the upstream parts of river- and wave-dominated deltas, respectively, increasing to 30 in the downstream parts of river-dominated deltas. These estimates will guide sedimentological studies that often have limited numbers of distributary-channel widths exposed in the rock record. To test the reliability of these alternative width–discharge scaling relationships in the rock record, paleodischarges were estimated for the well-studied Cretaceous lower Mesa Rica Sandstone Formation, USA. Comparison of these results with the more complex Chézy-derived method suggests that these new scaling relationships are accurate. Hence, it is proposed that the scaling relationships obtained from modern deltas can be applied to the rock record, requiring fewer, and easier-to-measure, data inputs than previously published methods.
La identidad cultural y el ecoturismo bajo un enfoque de género:
Authors: Ruíz Alvarado Inés , Coll-Ramis Miquel Àngel , Ponce Castañeda Verónica Milagros , Torres-Sovero Claudia
Published: October 2023

La comunidad nativa Ese’ Eja de Infierno y su alianza con la empresa privada ha significado una intervención de un turismo sostenible en comunidad. A lo largo de veinte años se ha tejido una relación entre esta comunidad y Rainforest, que ha permitido el desarrollo del ecoturismo en la zona. A partir del covid-19 y el confinamiento, nuevas amenazas tomaron la comunidad y debilitaron su gestión en el proyecto de ecoturismo Posada Amazonas. El presente artículo propone un avance sobre el proyecto de investigación que aborda identidad cultural, género y ecoturismo en la comunidad nativa de Infierno bajo un enfoque de género. El artículo que presentamos es un primer resultado de una investigación interdisciplinaria situada en los estudios de culturales, la psicología y biología con entrevistas a líderes mujeres de la comunidad nativa Infierno y líderes de la comunidad Palma Real, utilizando el método participativo en talleres a jóvenes adolescentes y niñas y niños. El estudio evidencia la participación de la comunidad en el desarrollo del ecoturismo, la participación de mujeres líderes en el desarrollo de la comunidad, así como una preocupación por la pérdida de la lengua ese’ eja por parte de jóvenes y adolescentes. Al mismo tiempo, plantea cómo el acercamiento de la comunidad Palma Real a Infierno podría ser clave para el desarrollo del ecoturismo y el rescate de la lengua ese’ eja.