bluuebunny/crossref_metadata_2025 huggingface dataset:
A single-center retrospective comparison of pT1 substaging methods in bladder cancer
Authors: Kläger Johannes , Koeller Maximilian C. , Oszwald André , Wasinger Gabriel , D’Andrea David , Compérat Eva
Published: September 2024

Substaging of T1 urothelial cancer is associated with tumor progression and its reporting is recommended by international guidelines. However, it has not been integrated in risk stratification tools and there is no agreement on the best method to use for its reporting. We aimed to investigate the applicability, interobserver variability, and prognostic value of histological landmark based and micrometric (aggregate linear length of invasive carcinoma (ALLICA), microscopic vs. extensive system, Rete Oncologica Lombarda (ROL) system) substaging methods. A total of 79 patients with the primary diagnosis of T1 urothelial cancer treated with conventional transurethral resection and adjuvant BCG therapy between 2000 and 2020 at the Medical University of Vienna were included. The anatomical and metrical substaging systems were evaluated using agreement rate, Cohen’s kappa, Kendall’s tau, and Spearman rank correlation. Prognostic value for high-grade recurrence or T2 progression was evaluated in uni- and multivariable analysis. Applicability and reproducibility were good to moderate and varied between substaging methods. Obstacles are mainly due to fragmentation of samples. Anatomical substaging was associated with progression in univariable and multivariable analysis. In our cohort, we could only identify anatomical landmark–based substaging to be prognostic for T2 progression. A major obstacle for proper pathological assessment is fragmentation of samples due to operational procedure. Avoiding such fragmentation might improve reproducibility and significance of pathological T1 substaging of urothelial cancer.
Optihybrid: a modified firebug swarm optimization algorithm for optimal sizing of hybrid renewable power system
Authors: Abd El-Sattar Hoda , Kamel Salah , Hashim Fatma A. , Sabbeh Sahar F.
Published: September 2024

In areas where conventional energy sources are unavailable, alternative energy technologies play a crucial role in generating electricity. These technologies offer various benefits, such as reliable energy supply, environmental sustainability, and employment opportunities in rural regions. This study focuses on the development of a novel optimization algorithm called the modified firebug swarm algorithm (mFSO). Its objective is to determine the optimal size of an integrated renewable power system for supplying electricity to a specific remote site in Dehiba town, located in the eastern province of Tataouine, Tunisia. The proposed configuration for the standalone hybrid system involves PV/biomass/battery, and three objective functions are considered: minimizing the total energy cost (COE), reducing the loss of power supply probability (LPSP), and managing excess energy (EXC). The effectiveness of the modified algorithm is evaluated using various tests, including the Wilcoxon test, boxplot analysis, and the ten benchmark functions of the CEC2020 benchmark. Comparative analysis between the mFSO and widely used algorithms like the original Firebug Swarm Optimization (FSO), Slime Mold Algorithm (SMA), and Seagull Optimization Algorithm (SOA) demonstrates that the proposed mFSO technique is efficient and effective in solving the design problem, surpassing other optimization algorithms.
Long-term outcomes of sentinel lymph node navigation surgery for early-stage cervical cancer
Authors: Togami Shinichi , Furuzono Nozomi , Mizuno Mika , Yanazume Shintaro , Kobayashi Hiroaki
Published: September 2024

Background

Sentinel lymph node navigation surgery, which identifies the sentinel lymph node in early cervical cancers and omits systemic pelvic lymphadenectomy in cases where no lymph node metastasis is present, has recently gained attention. However, there are few reports on lymph node recurrence and the long-term outcomes of cervical cancer surgery performed using sentinel lymph node navigation surgery. In this study, we aimed to evaluate the long-term outcomes of sentinel node navigation surgery for early-stage cervical cancer.

Methods

One hundred thirty-eight patients with cervical cancer were enrolled. Sentinel lymph nodes were identified by injecting 99 m Technetium-labeled phytate and indocyanine green into the uterine cervix. Surgery and survival outcomes were also analyzed.

Results

The median age and body mass index of the patients were 40 years (20–78) and 21.7 kg/m2 (16.5–50.4), respectively. Open surgery, laparoscopic surgery, and robotic surgery were performed in 77 (56%), 53 (38%), and 8 (6%) patients, respectively. The overall and bilateral detection rates of the sentinel lymph node were 100% and 94%, respectively. Only one case (0.7%) exhibited lower extremity lymphedema, and pelvic lymphocele was observed in three cases (2.2%). Four cases (3%) experienced recurrence over a median follow-up of 57.5 months (range, 2–115 months), with five-year recurrence-free and overall survival rates of 97% and 97.3%, respectively.

Conclusions

Our results demonstrate that sentinel node navigation surgery may be safe and effective for early-stage cervical cancer.
Clinical outcomes of first-line combination therapy with immune checkpoint inhibitor for metastatic non-clear cell renal cell carcinoma: a multi-institutional retrospective study in Japan
Authors: Yoshimura Akihiro , Kato Taigo , Nakai Yasutomo , Tsujihata Masao , Toyoda Shingo , Sato Mototaka , Matsuzaki Kyosuke , Nakata Wataru , Takao Tetsuya , Inoguchi Syunsuke , Okuda Yohei , Yamamichi Gaku , Ishizuya Yu , Yamamoto Yoshiyuki , Hatano Koji , Kawashima Atsunari , Takada Shingo , Inoue Hitoshi , Nishimura Kensaku , Miyake Osamu , Fujita Kazutoshi , Nakayama Masashi , Nishimura Kazuo , Nonomura Norio
Published: September 2024

Background

In metastatic clear cell renal cell carcinoma (ccRCC), recent studies have shown promising efficacy of immune checkpoint inhibitor (ICI) combination therapy. However, there are insufficient evidences about clinical efficacy and safety of ICI combination therapy in metastatic non-ccRCC (nccRCC).

Methods

We retrospectively investigated 44 patients treated with nivolumab plus ipilimumab (ICI + ICI group) or anti-PD-1/PD-L1 inhibitor plus tyrosine kinase inhibitors (TKI) (ICI + TKI group), and assessed clinical efficacy in both groups.

Results

Of all patients, overall response rate and disease control rate for ICI combination treatments were 36.3% and 75%, respectively. The median progression-free survival (PFS) and overall survival (OS) was 8.8 and 23.9 months, respectively. Multivariate analysis revealed that the presence of liver metastasis significantly affected worse PFS and OS (p = 0.035 and p = 0.049). Importantly, PFS and OS seemed similar in ICI + ICI group and ICI + TKI group (p = 0.778 and p = 0.559). Although the discontinuation rate of the combination therapy due to adverse effects in patients aged ≥ 75 years was significantly higher compared to that in patients aged < 75 years (45% versus 12%, p = 0.017), there were no significant differences in PFS and OS between two groups (p = 0.290 and p = 0.257, respectively).

Conclusion

This study confirms clinical benefit of ICI combination therapy for metastatic nccRCC patients in real-world settings. Furthermore, the effectiveness of combination therapy was comparable between patients aged < 75 and those ≥75 years with respect to clinical prognosis.
Evaluation under loading detects medial meniscus extrusion in patients with reconstructed anterior cruciate ligament and restricted knee extension
Authors: Ishii Yosuke , Nakamae Atsuo , Akinori Nekomoto , Hashizume Takato , Okinaka Riko , Sugimoto Miharu , Matsumura Kohei , Ishikawa Masakazu , Takahashi Makoto , Adachi Nobuo
Published: September 2024

Purpose

Some patients who undergo anterior cruciate ligament (ACL) reconstruction experience abnormal mechanical stress in the meniscus. Medial meniscal extrusion (MME) is reflected in the pathological condition of the meniscus, which expands owing to repetitive mechanical stress. Thus, the effect of the reconstructed ACL on increasing MME under weight-bearing conditions remains unclear. This study investigated the effect of ACL reconstruction on meniscal extrusion under non-weight-bearing and weight-bearing conditions.

Methods

Seventeen patients who underwent unilateral ACL reconstruction (ACL group) and 20 age-matched healthy volunteers (control group) were enrolled. Ultrasonography was performed in the supine, standing, and walking positions in preoperative and postoperative ACL patients. MME during walking was evaluated based on the dynamic behavior of extrusion, and kinetic and kinematic data were synchronously obtained. Moreover, the ACL group underwent magnetic resonance imaging (MRI) evaluation at two points: preoperatively and 12 months postoperatively, and the ultrasound findings were compared.

Results

MME in the supine position measured using both ultrasonography and MRI was not significantly different preoperatively and postoperatively in the ACL group. However, postoperative MME and dynamic behavior of extrusion under standing and walking conditions were significantly higher than those in the preoperative state (dynamic behavior: 0.9 ± 0.4 mm preoperatively, 1.2 ± 0.4 mm postoperatively). Moreover, the deficits in knee extension during walking persisted postoperatively and were significantly higher than those in the control group.

Conclusion

MME in patients with ACL reconstruction including meniscus repair was different under mechanical stress compared to the non-weight bearing condition.
BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition
Authors: Pervushin N. V. , Nilov D. K. , Pushkarev S. V. , Shipunova V. O. , Badlaeva A. S. , Yapryntseva M. A. , Kopytova D. V. , Zhivotovsky B. , Kopeina G. S.
Published: September 2024

The development of drug resistance reduces the efficacy of cancer therapy. Tumor cells can acquire resistance to MDM2 inhibitors, which are currently under clinical evaluation. We generated RG7388-resistant neuroblastoma cells, which became more proliferative and metabolically active and were less sensitive to DNA-damaging agents in vitro and in vivo, compared with wild-type cells. The resistance was associated with a mutation of the p53 protein (His193Arg). This mutation abated its transcriptional activity via destabilization of the tetrameric p53-DNA complex and was observed in many cancer types. Finally, we found that Cisplatin and various BH3-mimetics could enhance RG7388-mediated apoptosis in RG7388-resistant neuroblastoma cells, thereby partially overcoming resistance to MDM2 inhibition.
Carboxymethylation of viscose and cotton fibers: comparisons of water retention and moisture sorption
Authors: Bogner Paul , Schlapp-Hackl Inge , Hummel Michael , Bechtold Thomas , Pham Tung , Manian Avinash P.
Published: September 2024

The aim of the work was to compare the water retention and moisture sorption of viscose (CV) and cotton (Co) fibers carboxymethylated from aqueous media, in presence of NaOH, with sodium monochloroacetate. It was shown previously that under the same treatment conditions, the degree of carboxymethylation was higher in CV and so was the depth within fiber structures to which the carboxymethylation reactions occurred. It was also shown previously, that in terms of their capacity for sorption of a cationic dye (methylene blue), the Co performed better than CV. In this work, the same fibers were tested for their water retention and moisture sorption propensities. The two were sensitive both to the degree of carboxymethylation and the inherent properties of fibers (accessibility, degree of swelling, hornification). But the moisture sorption levels were less sensitive to the degree of carboxymethylation and more to inherent fiber properties whereas the reverse was observed for water retention. In contrast to the prior observations with dye sorption, CV performed better than Co in both moisture sorption and water retention. The poor performance of CV in dye sorption was attributed to the greater depth of carboxymethylation within the fibers that hindered dye permeation, but the same feature was observed to result in better performance (water retention) or not to hinder performance (moisture sorption). These observations highlight the contrasting effects that may arise, of a given set of treatment parameters (fiber type, alkali level in treatment), on efficacy of the product performance.
Population genetic structure and range limits of Prostanthera cineolifera (Lamiaceae), a vulnerable shrub with a patchy distribution
Authors: Palsson Ruth L. , Telford Ian R. H. , Bruhl Jeremy J. , Andrew Rose L.
Published: September 2024

Integrating molecular data is essential for clarifying the distributions and genetic structures of species that have histories of misidentification and misapplication of names. There has been confusion about the species limits of the Vulnerable Prostanthera cineolifera with respect to morphologically similar specimens in the Hunter Valley, New South Wales, Australia and morphologically dissimilar specimens in the Lower Hawkesbury Valley, New South Wales, and from north-eastern New South Wales. To test the species limits of P. cineolifera, and related taxa, specimens were collected from across the range and augmented with herbarium specimens. We used morphometric analysis of 18 morphological characters across 51 samples. Using the DArTseq reduced representation sequencing platform, 4010 single-nucleotide polymorphisms (SNPs) across 110 individuals were recovered for molecular analysis. Both morphological and molecular analyses produced three concordant clusters (A) P. cineolifera, (B) a group sharing similarities with P. sp. Hawkesbury (B.J.Conn 2591), and (C) a group allied with P. lanceolata and P. ovalifolia. These results indicate that the specimens form north-eastern New South Wales are more likely to be P. lanceolata, not P. cineolifera, and that specimens from the Lower Hawkesbury are of an undescribed species with the phrase name P. sp. Hawkesbury (B.J.Conn 2591). Within P. cineolifera there was pronounced genetic differentiation among populations. Little evidence of inbreeding was observed, but the newly recognised, more isolated populations had the lowest genetic diversity. This study provides new information about the range of the species and its genetic structure that informs the conservation priorities for this species.
Perceptions versus performance: Assessing teacher learning in asynchronous online professional development
Authors: Li Jingxian , Copur-Gencturk Yasemin
Published: September 2024

Teacher learning in asynchronous online professional development (PD) is often measured by self-reported instruments, despite uncertainties regarding teachers’ accuracy in their self-assessment of learning. This study explored whether teachers’ self-reported gains in content knowledge for teaching aligned with those measured by direct assessments. Through quantitative analyses of data collected from 57 middle school mathematics teachers who participated in a fully asynchronous online PD program, we found no significant correlation between teachers’ self-reported knowledge gains and those measured by direct assessments. Additionally, we examined the role of teachers’ use of self-regulated learning (SRL) strategies, namely organization, elaboration, and monitoring, in their learning from the PD program by conducting linear regression analyses. Our results indicated that teachers who frequently monitored their understanding of the PD content demonstrated greater gains in their content knowledge as measured by direct assessments. However, none of the SRL strategies predicted the accuracy of teachers’ self-assessments of knowledge gains from the asynchronous online PD program. These findings raise concerns about relying solely on self-reported instruments to capture teachers’ learning in asynchronous online PD programs, and they emphasize the need for more robust and accurate outcome measures in the asynchronous online learning context.
AI-Related Threats to Information Sovereignty and Challenges for Research Ethics
Authors: Skulmowski Alexander
Published: September 2024

Unnoticed by most, some technology corporations have changed their terms of service to allow user data to be transferred to clouds and even to be used to train artificial intelligence systems. As a result of these developments, remote data collection may in many cases become impossible to be conducted anonymously. Researchers need to react by reconsidering their mode of data collection, raising awareness, and expanding informed consent to ensure information sovereignty. Considerations for data sharing are discussed.
Software product line testing: a systematic literature review
Authors: Agh Halimeh , Azamnouri Aidin , Wagner Stefan
Published: September 2024

A Software Product Line (SPL) is a software development paradigm in which a family of software products shares a set of core assets. Testing has a vital role in both single-system development and SPL development in identifying potential faults by examining the behavior of a product or products, but it is especially challenging in SPL. There have been many research contributions in the SPL testing field; therefore, assessing the current state of research and practice is necessary to understand the progress in testing practices and to identify the gap between required techniques and existing approaches. This paper aims to survey existing research on SPL testing to provide researchers and practitioners with up-to-date evidence and issues that enable further development of the field. To this end, we conducted a Systematic Literature Review (SLR) with seven research questions in which we identified and analyzed 118 studies dating from 2003 to 2022. The results indicate that the literature proposes many techniques for specific aspects (e.g., controlling cost/effort in SPL testing); however, other elements (e.g., regression testing and non-functional testing) still need to be covered by existing research. Furthermore, most approaches are evaluated by only one empirical method, most of which are academic evaluations. This may jeopardize the adoption of approaches in industry. The results of this study can help identify gaps in SPL testing since specific points of SPL Engineering still need to be addressed entirely.
Novel and classical methods similarly describe variation in territory size among males in Neotropical poison frogs with contrasting reproductive and behavioral strategies
Authors: Betancourth-Cundar Mileydi , Amézquita Adolfo , Cadena Carlos Daniel
Published: September 2024

Territoriality is a form of social dominance concerning the use of space that ensures the territory owner primary access to critical resources. The territory is defended with visual displays, advertisement calls, physical attacks, or chemical signals. The territory is frequently estimated by mapping locations where an animal is observed engaging in territorial behavior or by tracking. However, these approaches may over- or underestimate the areas defended. Thus, the use of approaches explicitly determining defended areas is critical to properly characterize the territory. Intrusion experiments can elicit a response in territory holders, allowing one to characterize their aggressive responses; however, the aggressive response depends on the species. We describe an approach to experimentally estimate the territory size using playback experiments in a species that exhibits a stereotypical phonotactic response: the nurse frog, Allobates aff. trilineatus and develop a new behavioral index that allows assessing territory size in response to playbacks for a species with non-stereotyped phonotactic response: the endangered Lehmann’s poison frog, Oophaga lehmanni. We conducted 772 playback experiments on 18 males of A. aff. trilineatus, and 222 on nine males of O. lehmanni. We analyzed the results of playback experiments with three different area estimators regularly used to estimate space use and evaluated whether these estimates are correlated. The shape and size of territories varied among individuals and estimators in both species. Although we found that the absolute size of the territory depends on the method used, estimates were strongly correlated, meaning that different estimators similarly describe variation in territory size among males. Choosing an analysis method may not be particularly important for studying the characteristics of territoriality over space and time but using a systematic and standardized experimental approach that also incorporates the particularities of the aggressive response of each species is essential to understand the evolution of space use by poison frogs and other territorial species.
Anisotropic thermoelectric power in single crystalline Mg1-xAlxB2 compounds
Authors: Toliński Tomasz , Oganisian Karen , Karpiński Janusz , Rogacki Krzysztof
Published: September 2024

The thermoelectric power of single crystalline Mg1−xAlxB2 compounds is measured and analyzed along the main crystallographic directions (ab-plane and c-axis direction). It is shown that the classical model of thermoelectric power with phonon drag and diffusion terms provides satisfactory explanation of the temperature dependence of the Seebeck parameter S(T). Agreement of S(T) with the study of resistivity is achieved with some variation of the Debye temperature being a model-sensitive parameter. Presence of positive and negative charge carriers is observed and competing contributions of the π and σ bands are discussed.
Diatom dynamics during the last six centuries in Lake Odensjön: a new varved sediment record from southern Sweden
Authors: Silvester Ethan L. , Ljung Karl , Bindler Richard , Hertzman Hanna , Lodi Giulia , Hammarlund Dan
Published: September 2024

Varved lake sediments offer valuable insight into past environmental conditions with high temporal resolution and precise chronological control. A combination of diatom and geochemical analyses of the recently deposited sediments of Odensjön, a small dimictic lake in southern Sweden, shows alternating light and dark laminae composed of greater amounts of biogenic silica and organic matter, respectively. As confirmed by independent radiometric dating and Pb pollution data, and supported by scanning electron microscopy of individual laminae, these features represent ongoing deposition of biogenic varves. Corresponding diatom and geochemical data obtained from a 92-cm long freeze core provide evidence of substantial lake-ecosystem dynamics during the last six centuries, related mainly to variations in light penetration and wind shear driven by human-induced changes in catchment vegetation. The diatom assemblage of Odensjön’s varved sediments is dominated by planktonic species, primarily Asterionella formosa, Fragilaria saxoplanktonica and Discostella lacuskarluki during periods of forest cover, while increased catchment openness from the mid-1500s to the late 1800s led to increased abundance of Lindavia comensis. Long-term variations in climate and land use, mediated through changing length of the ice-cover season and nutrient input, respectively, probably contributed to the observed trends, as well as to variations in the appearance and visibility of the varve record across the sampled sediment sequence. Odensjön represents the southernmost varved sediment record in Fennoscandia documented to date, offering potential to study the effects of various types of external forcing on its sensitive lacustrine ecosystem since the Late Weichselian deglaciation. In the present study, we investigated the possibility of assessing the local impacts of two major, historically documented volcanic events, Laki 1783–84 and Tambora 1815, which are known to have affected European societies. Although the mildly alkaline waters of the lake are well buffered and hence relatively resilient to volcanic acid deposition, a minor response to the Laki eruption may be recorded in the diatom stratigraphy.
Theoretical calculation methods of stable bearing capacity for thin-walled shells with corrosion and variable temperature
Authors: Liu Cheng Huijuan , Lacidogna Giuseppe
Published: September 2024

Thin-wall shells (steel plates, steel cylindrical shells, steel spherical shells, etc.) are widely used in many engineering fields such as construction, machinery, chemical industry, navigation, and aviation because of their light weight and high strength. Their failure modes under static pressure or impact dynamic load are mostly buckling instability, and the failure is very sudden, often causing structural failure or even catastrophic accidents without obvious symptoms. In this framework, the significance of this paper is that it considers the influence of external environment corrosion on steel shells' bearing capacity using plate and shell classical stability theory, and investigates the stable bearing capacity of thin-wall steel shells in view of corrosion impact. By this approach, a theoretical calculating method for the time-varying stable bearing capacity of plate and shell thin-walled steel members under the simultaneous action of corrosion and temperature changes is obtained, providing a useful theory for complex engineering practices such as corrosion and temperature changes, including fire actions. Noted that for this method with no analytical solution found, its numerical solutions are given in the appendixes.
Exprimer la dynamique spatiale par l’utilisation de l’adjectif grave et ses équivalents polonais dans les textes de loi
Authors: Śliwa Dorota
Published: September 2024

Starting from the observation that the construction of vague reference in legal texts is intended by the legislator, we examine the intensifier adjective grave linked to linguistic vagueness. The aim is to define the meanings of grave and the role of the noun it qualifies, and to identify Polish equivalents in comparable and parallel legal texts. After mentioning studies on vagueness and vague reference, we analyse definitions that indicate two meanings: ‘importance’ and ‘consequence. The ‘cause-consequence’ relationship becomes central to the study of the categories of intensifiable nouns and grave meanings. The Polish equivalents prove that it is polysemous and that the place of the N in the logical relation must be taken into account.
Are Cities Decisive for Life Satisfaction? A Structural Equation Model for the European Population
Authors: Nicolás-Martínez Catalina , Pérez-Cárceles María Concepción , Riquelme-Perea Prudencio José , Verde-Martín Carmen María
Published: September 2024

The growth of cities is an unstoppable phenomenon that began in the last century and will undoubtedly be one of the challenges of the current century. It is not only a question of urbanization; its implications and consequences extend to the economy, society, culture and the environment. The capacity of cities as engines of change and progress cannot be questioned, and its consequences will alter the lives of their citizens, who will search, in a more liquid world, for the best places to live. Therefore, this study aims to examine the influence of perception of urban quality (PUQ) and social trust and security (STS) on the life satisfaction (LS) of European citizens to find out if these variables are essential for the population living in Europe. The data were selected from the European Urban Audit survey, which covers 40,597 people living in 80 European cities. The analysis in this study is carried out at the city level. The partial least squares structural equation modelling approach was applied to verify the hypotheses. The findings reveal a positive correlation between PUQ and STS with LS, with STS being a mediator between PUQ and LS. These results underline that improving the perception of the urban environment can significantly increase well-being, contributing more than 70% to citizens' life satisfaction. This multidisciplinary analysis highlights the importance of considering various urban dimensions in planning and public policies to foster prosperous and satisfactory urban development.
Revolutionizing Waste Management: Solidification of Landfill Leachates Using Alkali-Activated Slag
Authors: Sithole Thandiwe , Jobodwana Lisakhanya , Magedi Felicia
Published: September 2024

Landfill leachate is a highly hazardous effluent characterized by a high concentration of recalcitrant pollutants, presenting a significant environmental challenge. This study investigated the solidification of landfill leachate contaminants using sodium hydroxide-activated Granulated Blast Furnace Slag (GBFS). The stability of the resulting geopolymer was evaluated through unconfined compressive strength and leaching tests. Optimal curing conditions were identified as 7 days at a sodium hydroxide concentration of 12 M, achieving an unconfined compressive strength of 45.738 MPa at a liquid-to-solid ratio of 15%. A linear relationship was observed between the liquid-to-solid ratio and flow workability, with maximum flow workability evidenced by an average diameter of 242 mm at a liquid-to-solid ratio of 0.25. However, a minimum liquid-to-solid ratio of 0.15 was necessary to obtain a workable mortar. The produced geopolymers were characterized using X-ray Fluorescence (XRF) for mineralogical analysis, Scanning Electron Microscopy (SEM) for morphological examination, and the Toxicity Characteristic Leaching Procedure (TCLP) for leaching tests. The findings demonstrated the successful solidification of landfill leachate using GBFS geopolymer. The leachability tests revealed that the geopolymer did not release metals in concentrations exceeding the allowable limits set by the United States Environmental Protection Agency (USEPA), indicating effective encapsulation of the pollutants within the geopolymer matrix. Furthermore, the resultant geopolymer brick is eco-sustainable and can be classified as a green construction material.
The roles that students’ ethnicity and achievement levels play in teachers’ choice of learning materials in online teaching: evidence from two experimental studies
Authors: Schlag Sabine , Glock Sabine
Published: September 2024

Research has shown that, in general, students are treated differently on the basis of their achievement levels and ethnicity. Such differential treatment might also result in the administration of different learning materials, and so far, not much is known about how teachers choose these materials for different students. In two vignette studies, we investigated which student factors influence teachers’ choice of materials. In Study 1, preservice teachers were asked to choose between an easy or difficult instructional video with the same content in response to vignettes that differed by students’ ethnic minority or majority background. In Study 2, preservice teachers could choose between text or video materials with the same content. The student descriptions varied systematically in achievement (high vs. low) and ethnic background (minority vs. majority). The results of Study 1 showed that ethnic minority background students were significantly more often given the easy video than ethnic majority background students. In Study 2, the results showed that student achievement was the crucial factor. Low-achieving students were given the video significantly more often, whereas high-achieving students were more often given the text. Both studies provide initial insights into how teachers’ material choice might be influenced by student characteristics.
How can the Social Family Climate Contribute to Emotional Intelligence in Preventing Suicidal Ideation and Promoting Life Satisfaction Among Adolescents?
Authors: Peláez-Fernández María Angeles , Mérida-López Sergio , Yudes Carolina , Extremera Natalio
Published: September 2024

While findings have documented the association between emotional intelligence, life satisfaction, and suicidal ideation among adolescents, few studies have investigated the moderating effect of family climate on the association. This study examined the moderating effect of family cohesion, expressiveness, and conflict on the relationships between emotional intelligence, life satisfaction, and suicidal ideation among Spanish adolescents. A total of 2,722 adolescents aged 12 to 18 (Mage = 14.11, SD = 1.42, 52.8% girls) formed the sample. The interaction effects were significant, with family conflict mitigating the effects of emotional intelligence on life satisfaction, and family cohesion and expressiveness strengthening the effects of emotional intelligence on suicidal ideation. These findings provide additional evidence for the protective role of family cohesion and expressiveness in adolescent suicidal ideation, and the harmful role of family conflict in adolescent wellbeing. The results imply that enhancing family cohesion and expressiveness and reducing family conflict may be a promising way to boost the link between emotional intelligence and life satisfaction and to prevent suicidal ideation among adolescents.
Occurrence and epidemiological consequences of Erysiphe neolycopersici on tomato plants in Mauritius
Authors: Lebeda Aleš , Lobin Kanta Kumar , Mieslerová Barbora , Křivánková Tereza , Kitner Miloslav
Published: September 2024

Leveillula taurica has until recently been believed to be the causal pathogen of powdery mildew of tomatoes in Mauritius. However, in the year 2022, another powdery mildew species was detected on tomatoes under culture in various tomato growing localities of the island. Based on morphological comparison and molecular analysis, its identity was confirmed as Erysiphe neolycopersici (anam. Pseudoidium neolycopersici). This species has a worldwide distribution causing severe epidemics mainly on greenhouse tomatoes. There is evidence of the rapid spread of this pathogen during 2022–2023 causing serious infection of all tomato cultivars in greenhouse culture in Mauritius. The origin of these infections and its epidemiological consequences are discussed.
Geodiversification: The Evolution of Geodiversity Through Time
Authors: Stojilković Borut , Gray Murray
Published: September 2024

Geodiversity has gained significant attention in the last three decades due to various research endeavouring to bridge the gap between geo- and biodiversity. This paper points at yet another parallel between the two disciplines: just as biodiversity expansion (i.e. biodiversification) can be evaluated through time, geodiversity change can also be observed on a timescale and referred to as ‘geodiversification’. The paper firstly reviews the biodiversification definition and some of its major events including the Cambrian explosion and Great Ordovician Biodiversification Event (GOBE) and suggests that being palaeontological, these can also be regarded as geodiversification events. In relation to that, the paper defines geodiversification and provides examples of important geodiversification events in the Earth’s history and some local-scale examples. The results show that major biodiversification events can occur due to the evolution of geodiversity.
A Study on Microstructural Evolution and Corrosion Behavior of Ti36-Al16-V16-Fe16-Cr16 High-Entropy Alloy Fabricated via Spark Plasma Sintering Technology
Authors: Uyor Uwa O. , Popoola Abimbola P. I. , Popoola Olawale M.
Published: September 2024

This study focused on the synthesis of Ti36-Al16-V16-Fe16-Cr16 high-entropy alloys (HEAs) through spark plasma sintering to ascertain their corrosion resistance performance. Varied sintering temperatures, ranging from 700 to 1100 °C were employed to discern their impact on the alloy's characteristics. The fabricated HEAs underwent characterization using scanning electron microscopy and X-ray diffraction. A potentiodynamic polarization measurement was employed to compare the electrochemical properties of HEAs sintered at different temperatures in sulfuric and chloride aggressive media. The study outcomes indicate that the HEA sintered at 1000 °C exhibited superior corrosion resistance compared to other HEAs at other temperatures. This study contributes valuable insights into the nuanced relationship between sintering temperature, microstructure, and corrosion resistance of Ti36-Al16-V16-Fe16-Cr16 HEAs.
Mindfulness-Based Intervention for Schoolteachers: Comparison of Video-Conferencing Group with Face-to-Face Group
Authors: Chan Winnie W. L. , Wu Ka Chun , Li Shirley X. , Tsang Kitty K. Y. , Shum Kathy K. , Kwan Hong Wang , Su Michael R. , Lam Shui-fong
Published: September 2024

Objectives

The COVID-19 pandemic has brought substantial mental health challenges as well as significant changes in the delivery of clinical care and interventions, such as switching from traditional face-to-face to online mode. This study aimed to compare the effectiveness and the course experience of a video-conferencing mindfulness-based intervention (MBI) with that delivered face-to-face.

Method

Schoolteachers (N = 170) were randomly assigned to face-to-face group (n = 94) and video-conferencing group (n = 76) for an 8-week MBI. The schoolteachers’ well-being, including psychological distress, insomnia, perceived stress, mindfulness, positive and negative affect, and life satisfaction, was measured before and after the MBI. Attendance, treatment fidelity, home practice compliance, and program acceptability were collected after the MBI. Qualitative feedback from the two groups was also collected to explore the differences in participants’ subjective experiences.

Results

Both face-to-face and video-conferencing formats of MBI resulted in better general mental health, more positive affect, and higher life satisfaction, as well as significantly lower levels of insomnia, stress, and negative affect. Observed improvement was comparable between face-to-face and video-conferencing MBI. The two groups also showed comparable adherence, intervention fidelity, and program acceptability. Qualitative results showed that while video-conferencing MBI might be weaker in group process, it provided better accessibility for participants.

Conclusions

This study supported the effectiveness and feasibility of video-conferencing MBIs, which are highly accessible for teachers in need of mental health support. Further research exploring enhancements to the group process in video-conferencing MBIs may further improve the effectiveness of online programs.

Preregistration

This study is not pre-registered.
Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications
Authors: Kocaaga Banu , Bagimsiz Gamze , Alev Ibrahim Avni , Miavaghi Mehran Aliari , Sirkecioglu Ahmet , Batirel Saime , Guner Fatma Seniha
Published: September 2024

The development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by pH changes. These films are composed of MIL-101(Fe) particles and pectin polymers. MIL-101(Fe) was chosen for its high surface area, stability in aqueous environments, and biocompatibility, ensuring low toxicity to normal cells. MIL-101(Fe)-embedded-pectin hydrogels were synthesized and characterized using Fourier-transformed infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometry, particle size analysis, and goniometry. Rheological analysis assessed the hydrogels’ viscoelastic behavior, and UV-spectrophotometry was utilized for drug loading and release studies. The hydrogels exhibited shear-thinning properties, enhancing shape adaptability and recovery, crucial for wound-dressing applications. Controlled drug release was achieved by maintaining the PC solution’s pH between 8.2 and 9.8 during the drug-loading step. The hydrogel film’s impact on wound healing was evaluated through an in vitro wound healing assay, and cytotoxicity was assessed using a WST-1 cell proliferation assay with human dermal fibroblast cells. Results demonstrated that pectin composites enhance cell viability and support fibroblast cell migration without adverse effects, indicating their potential for effective wound healing applications. This study highlights the potential of MIL-101(Fe)-embedded-pectin hydrogels in advancing wound care technology.

Graphical Abstract

MIL-101(Fe)-embedded pectin film as wound dressing
Capturing the unobservable in AI development: proposal to account for AI developer practices with ethnographic audit trails (EATs)
Authors: Wu Yung-Hsuan
Published: September 2024

The prevalence of artificial intelligence (AI) tools has inspired social studies researchers, ethicists, and policymakers to seriously examine AI’s sociopolitical and ethical impacts. AI ethics literature provides guidance on which ethical principles to implement via AI governance; AI auditing literature, especially ethics-based auditing (EBA), suggests methods to verify if such principles are respected in AI model development and deployment. As much as EBA methods are abundant, I argue that most currently take a top-down and post-hoc approach to AI model development: Existing EBA methods mostly assume a preset of high-level, abstract principles that can be applied universally across contexts; meanwhile, current EBA is only conducted after the development or deployment of AI models. Taken together, these methods do not sufficiently capture the very developmental practices surrounding the constitution of AI models on a day-to-day basis. What goes on in an AI development space and the very developers whose hands write codes, assemble datasets, and design model architectures remain unobserved and, therefore, uncontested. I attempt to address this lack of documentation on AI developers’ day-to-day practices by conducting an ethnographic “AI lab study” (termed by Florian Jaton), demonstrating just how much context and empirical data can be excavated to support a whole-picture evaluation of AI models’ sociopolitical and ethical impacts. I then propose a new method to be added to the arsenal of EBA: Ethnographic audit trails (EATs), which take a bottom-up and in-progress approach to AI model development, capturing the previously unobservable developer practices.
The entangled human being – a new materialist approach to anthropology of technology
Authors: Puzio Anna
Published: September 2024

Technological advancements raise anthropological questions: How do humans differ from technology? Which human capabilities are unique? Is it possible for robots to exhibit consciousness or intelligence, capacities once taken to be exclusively human? Despite the evident need for an anthropological lens in both societal and research contexts, the philosophical anthropology of technology has not been established as a set discipline with a defined set of theories, especially concerning emerging technologies. In this paper, I will utilize a New Materialist approach, focusing particularly on the theories of Donna Haraway and Karen Barad, to explore their potential for an anthropology of technology. I aim to develop a techno-anthropological approach that is informed and enriched by New Materialism. This approach is characterized by its relational perspective, a dynamic and open conception of the human being, attention to diversity and the dynamics of power in knowledge production and ontology, and an emphasis on the non-human. I aim to outline an anthropology of technology centered on New Materialism, wherein the focus, paradoxically, is not exclusively on humans but equally on non-human entities and the entanglement with the non-human. As will become clear, the way we understand humans and their relationship with technology is fundamental for our concepts and theories in ethics of technology.
Spatial and Temporal Analysis of Severe Fever with Thrombocytopenia Syndrome in Anhui Province from 2011 to 2023
Authors: Chu Xiu-Jie , Song Dan-Dan , Chu Na , Wu Jia-Bing , Wu Xiaomin , Chen Xiu-Zhi , Li Ming , Li Qing , Chen Qingqing , Sun Yong , Gong Lei
Published: September 2024

Objective

To analyze the spatial autocorrelation and spatiotemporal clustering characteristics of severe fever with thrombocytopenia syndrome(SFTS) in Anhui Province from 2011 to 2023.

Methods

Data of SFTS in Anhui Province from 2011 to 2023 were collected. Spatial autocorrelation analysis was conducted using GeoDa software, while spatiotemporal scanning was performed using SaTScan 10.0.1 software to identify significant spatiotemporal clusters of SFTS.

Results

From 2011 to 2023, 5720 SFTS cases were reported in Anhui Province, with an average annual incidence rate of 0.7131/100,000. The incidence of SFTS in Anhui Province reached its peak mainly from April to May, with a small peak in October. The spatial autocorrelation results showed that from 2011 to 2023, there was a spatial positive correlation(P < 0.05) in the incidence of SFTS in all counties and districts of Anhui Province. Local autocorrelation high-high clustering areas are mainly located in the south of the Huaihe River. The spatiotemporal scanning results show three main clusters of SFTS in recent years: the first cluster located in the lower reaches of the Yangtze River, the eastern region of Anhui Province; the second cluster primarily focused on the region of the Dabie Mountain range, while the third cluster primarily focused on the region of the Huang Mountain range.

Conclusions

The incidence of SFTS in Anhui Province in 2011–2023 was spatially clustered.
Climate Change Projections for Stroke Incidence in Taiwan: Impact of 2 °C and 4 °C Global Warming Level
Authors: Wu Wei-Te , Kono Miku , Lee Chuan-Pin , Chang Yu-Yin , Yang Yao-Hsu , Lin Ching-Chun , Liu Tzu-Ming , Li Hsin-Chi , Chen Yung-Ming , Chen Pau-Chung
Published: September 2024

Objectives

This study aimed to establish the exposure-lag-response effect between daily maximum temperature and stroke-related emergency department visits and to project heat-induced stroke impacts under global warming levels (GWL) of 2 °C and 4 °C.

Methods

Stroke-related emergency department visits in Taiwan from 2001 to 2020 were identified using the National Health Insurance Research Database (NHIRD). The study population consisted of 1,100,074 initial stroke cases matched with 2,200,148 non-stroke controls. We employed Distributed Lag Nonlinear Models (DLNM) in a case-crossover study to investigate the association between temperature and stroke. Generalized Estimating Equations (GEE) models with a Poisson function were used to correlate high-temperature exposure with annual stroke incidence rates. Projections were made under two global warming scenarios, GWL 2.0 °C and 4.0 °C, using Coupled General Circulation Model (GCMs). Baseline data from 1995 to 2014 were transformed for spatial distribution at the township level. Geographic Information System (GIS) spatial analysis was performed using Quantum GIS 3.2.0 software.

Results

DLNM exposure-lag-response effect revealed that daily maximum temperature exceeding 34 °C significantly increased the risk of stroke-related emergency department visits, particularly for ischemic stroke. Under the 2 °C GWL scenario, the frequency of days with temperatures surpassing 34 °C is projected to rise substantially by the median year of 2042, with a further increase to 92.6 ± 18.0 days/year by 2065 under the 4 °C GWL scenario. Ischemic stroke showed the highest increase in temperature-related incidence rates, notably rising from 7.80% under the GWL 2 °C to 36.06% under the GWL 4 °C. Specifically, the annual temperature-related incidence rate for ischemic stroke is expected to increase significantly by 2065. Regions such as Taichung, Hsinchu, Yilan, and Taitung demonstrated pronounced changes in heat-related ischemic stroke incidence under the GWL 4 °C.

Conclusions

The findings emphasize the importance of addressing temperature-related stroke risks, particularly in regions projected to experience significant temperature increases. Effective mitigation strategies are crucial to reduce the impact of rising temperatures on stroke incidence and safeguard public health.