bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular phenotype of bronchial asthma in combination with arterial hypertension
Authors: Брагина Е.Ю. , Гончарова И.А. , Фрейдин М.Б. , Жалсанова И.Ж. , Гомбоева Д.Е. , Бушуева О.Ю. , Полоников А.В. , Назаренко М.С. , Панасенко А.В. , Пузырёв В.П.
Published: December 2020

В работе изучены ассоциации однонуклеотидных полиморфных вариантов (SNPs), связанных с количественными изменениями экспрессии (eQTL) генов TLR4, CAT, IL10, ADRB2, CST3, ICAM1, IRF6, NFKB1, PNP, SELL, SPP1, SMC2, SERPINA1, IL2RB, HSPA4, FOS, NT5C2, BHLHE40 у пациентов с бронхиальной астмой, артериальной гипертензией и их сочетанием. В результате установлены ассоциации с развитием астмы в сочетании с артериальной гипертензией для аллелей, генотипов и гаплотипов, образованных отдельными SNP генов TLR4, CAT, ANG и RNASE4, отличающихся от SNP, ассоциированных с «изолированными» астмой и артериальной гипертензией.

Associations of eQTL SNPs of the TLR4, CAT, IL10, ADRB2, CST3, ICAM1, IRF6, NFKB1, PNP, SELL, SPP1, SMC2, SERPINA1, IL2RB, HSPA4, FOS, NT5C2, BHLHE40 genes with bronchial asthma, arterial hypertension and the comorbidity of these diseases were studied. As a results association of alleles, genotypes, and haplotypes formed by individual SNPs of TLR4, CAT, ANG, and RNASE4 genes with comorbidity of asthma and hypertension have been established which differ from SNPs associated with “isolated” asthma and arterial hypertension.
Study of polymorphisms and the methylation status of genes involved in glucocorticosteroid metabolism in patients with asthma and healthy individuals
Authors: Федорова Ю.Ю. , Карунас А.С. , Савельева О.Н. , Гималова Г.Ф. , Мурзина Р.Р. , Гатиятуллин Р.Ф. , Эткина Э.И. , Хуснутдинова Э.К.
Published: December 2020

Проведен поиск генетических и эпигенетических маркеров риска развития бронхиальной астмы (БА) и чувствительности к терапии глюкокортикостероидами (ГКС) у индивидов русской, татарской и башкирской этнической принадлежности. Установлено, что полиморфные варианты генов, участвующих в метаболизме ГКС (NR3C1, CRHR1, GLCCI1, ТBXT, FBXL7), влияют на особенности развития и течения БА. При анализе статуса метилирования гена глюкокортикоид-индуцированного транскрипта 1 GLCCI1 обнаружен повышенный уровень метилирования промоторной области гена GLCCI1 у больных БА.

The search for genetic and epigenetic markers of the risk asthma and sensitivity to glucocorticosteroid therapy (GCs) in Russians, Tatars and Bashkirs was performed. It was established that polymorphic variants of genes involved in the metabolism of GCs (NR3C1, CRHR1, GLCCI1, TBXT, FBXL7) affect the features of the development and course of asthma. An analysis of the methylation status of the glucocorticoid-induced transcript 1 GLCCI1 gene revealed an increased level of methylation of the promoter region of the GLCCI1 gene in asthma patients.
Characterization of genomic imbalance in patients with balanced chromosomal rearrangements and abnormal phenotypes
Authors: Миньженкова М.Е. , Маркова Ж.Г. , Гусева Д.М. , Маркова Т.В. , Демина Н.А. , Семенова Н.А. , Бессонова Л.А. , Васильева Т.А. , Дадали Е.Л. , Шилова Н.В.
Published: December 2020

Идентификация причин формирования аномалий развития у пациентов со сбалансированными хромосомными перестройками на сегодняшний день является актуальным и не в полной мере изученным направлением в цитогенетической практике, требующим разработки уникального подхода с использованием современных молекулярно-генетических технологий. Целью данного исследования явилась этиологическая диагностика геномного дисбаланса у пациентов со сбалансированными хромосомными перестройками и аномалиями развития. 20 пациентов с аномальным фенотипом и сбалансированными хромосомными перестройками, выявленными при стандартном кариотипировании, были обследованы методами хромосомного микроматричного анализа (ХМА) и FISH. Геномный дисбаланс (CNV) обнаружен в 13 случаях из 20, что составило 65%. Использование ХМА позволило установить, что в 69,2% случаев носительства сбалансированных хромосомных перестроек причиной аномального фенотипа являлось наличие микроделеций/микродупликаций, ассоциированных с точками разрывов при перестройках, а в 20,8% случаев наблюдались микроделеции/микродупликации на хромосомах, не задействованных в аберрациях. Несмотря на то, что ХМА позволил выявить причины аномалий развития в большинстве случаев, 7 пациентам (35%) не удалось установить окончательный молекулярно-цитогенетический диагноз. Более того, у некоторых пациентов выявленные CNVs не полностью отражают генотип-фенотип корреляцию, что требует проведения дополнительных молекулярно-генетических исследований. При отсутствии геномного дисбаланса при ХМА, а также при неполной генотип-фенотип корреляции, диагностика этиологии аномалий развития и патологического фенотипа должна быть продолжена молекулярными методами более высокого разрешения.

Identification of genomic imbalances in cases with balanced chromosomal rearrangements and abnormal phenotype is a current trends in cytogenetics practice, requiring the development of unique approach using modern molecular genetic technologies. The aim of this study is diagnostics etiologies of the abnormal phenotype in patients with balanced chromosomal rearrangements. We report the investigations results of 20 patients with abnormal phenotype and balanced chromosomal rearrangements by conventional cytogenetic analysis. Genomic imbalances by microarray studies detected in 13 of 20 cases (65%). Most of CNVs was microdeletion or microduplication at a rearrangement breakpoint (69.2%) and 20.8% microdeletion/microduplication in other chromosomes.
Possibility of using various D.melanogaster lines in genotoxicological studies
Authors: Неупокоева О.В. , Воронова О.Л. , Чурин А.А.
Published: December 2020

Исследована индукция мутаций цисплатином у самок дрозофил, несущих маркерные мутации yellow, white, singed в одной хромосоме, при скрещивании с самцами дикого типа Canton-S.

The induction of cisplatin mutations was studied in female Drosophila carrying yellow, white, singed marker mutations on the same chromosome when crossed with wild-type males Canton-S.
Genotoxic properties of some organophosphate pesticides
Authors: Егорова О.В. , Илюшина Н.А. , Аверьянова Н.С. , Кара Л.А. , Демидова Ю.В. , Масальцев Г.В. , Прокофьев Е.А. , Ревазова Ю.А.
Published: December 2020

С использованием теста Эймса и микроядерного теста in vivo на эритроцитах млекопитающих изучена генотоксичность некоторых фосфорорганических пестицидов, применяемых в сельском хозяйстве. Технические продукты хлорпирифоса и диазинона не проявляли генотоксичности ни в условиях in vitro, ни in vivo. Выявлены слабые мутагенные эффекты диметоата на штаммах бактерий. Некоторые технические продукты глифосата, диметоата, а также пиримифос-метил индуцировали цитогенетические нарушения у мышей линии CD-1. Наблюдаемые эффекты in vivo были низкими даже на уровне максимальных переносимых доз, поэтому все исследованные фосфорорганические пестициды могут быть отнесены к 3 или 4 классам опасности по критерию «мутагенность» согласно принятой в Российской Федерации классификации.

The genotoxicity of some organophosphate pesticides applied in agriculture was studied using the Ames test and the mammalian erythrocyte micronucleus test in vivo. Technical grade active ingredients (TGAI) of chlorpyrifos and diazinon did not show genotoxicity either in vitro or in vivo. The weak mutagenic effects of dimethoate were revealed with bacterial strains. Some TGAIs of glyphosate, dimethoate, and pyrimifos-methyl induced cytogenetic abnormalities in CD-1 mice. The observed effects in vivo were low even at the maximum tolerated doses. Therefore, according to the pesticide hygienic classification adopted in the Russian Federation all studied organophosphate pesticides can be assigned a 3 or 4 class of hazard upon the criterion “mutagenicity”.
The effect of ADAMTS1, RBFOX2, THBS1 and WHSC1 gene expression on the formation of a radiation-induced cellular response
Authors: Савченко Р.Р. , Васильев С.А. , Фишман В.С. , Сухих Е.С. , Грибова О.В. , Старцева Ж.А. , Мурашкина А.А. , Дорофеева А.В. , Шункова Д.М. , Лебедев И.Н.
Published: December 2020

Проведен анализ выживаемости клеток, оценка уровня фокусов белков репарации ДНК и частоты радиационно-индуцированных микроядер в условиях дифференциальной экспрессии генов ADAMTS1, RBFOX2, THBS1 и WHSC1 в модельных системах in vitro и в лимфоцитах периферической крови человека. Полученные результаты указывают на потенциальную возможность использования уровня экспрессии данных генов для выявления индивидов с повышенной радиочувствительностью.

In this study, we investigated the cell survival, the DNA repair foci level and the radiation-induced micronuclei frequency in the model systems in vitro and in the human peripheral blood lymphocytes with differential expression of ADAMTS1, RBFOX2, THBS1 and WHSC1 genes. The results indicate the potential opportunity of using these genes expression level to identify the individuals with increased radiosensitivity.
Еffect of different antioxidant drug on the level of dna-damage and redox potential of cells of spermatogenous tissue
Authors: Боровская Т.Г. , Вычужанина А.В. , Григорьева В.А. , Камалова С.И. , Кривова Н.А. , Заева О.Б.
Published: December 2020

Изучено влияние мексидола, дигидрокверцитина, диборнола и пара-тирозола на количество ДНК-повреждений и редокс-потенциал в клетках тестикулярной ткани крыс. Установлено, что в условиях ДНК-повреждений клеток сперматогенной ткани все исследуемые соединения, кроме мексидола, снижали в клетках число разрывов ДНК и оказывали нормализующее действие на их редокс-потенциал. Наибольшая терапевтическая активность выявлялась у дигидрокверцетина.

The effect of mexidol, dihydroquercetin, dibornol and paratyrosol on the amount of DNA damage and the redox potential in rat testicular tissue cells was studied. It was established, that all studied compounds, except mexidol, reduced the number of DNA breaks in the cells and had a normalizing effect on their redox potential under the conditions of DNA damage to spermatogenic tissue cells. The highest therapeutic activity was detected in dihydroquercetin.
Blocking Lithium Dendrite Growth in Solid-State Batteries with an Ultrathin Amorphous Li-La-Zr-O Solid Electrolyte
Authors: Sastre Jordi , Futscher Moritz H. , Pompizi Lea , Aribia Abdessalem , Priebe Agnieszka , Overbeck Jan , Stiefel Michael , Tiwari Ayodhya N. , Romanyuk Yaroslav E.
Published: December 2020

Lithium garnet Li7La3Zr2O12 (LLZO) electrolyte is a potential candidate for the development of solid-state batteries with lithium metal as high-capacity anode. But ceramic LLZO in the form of pellets or polycrystalline films can still suffer from lithium dendrite penetration because of surface and bulk inhomogeneities and grain boundaries with non-negligible electronic conductivity. In contrast, the amorphous phase of LLZO (aLLZO) possesses a grain-boundary-free microstructure with moderate ionic conductivity (10-7 S cm-1) and high electronic insulation (10-14 S cm-1), which in the form of thin coatings can offer resistance to lithium dendrite growth. We explore the electrochemical properties and applications of aLLZO ultrathin films prepared by sputtering deposition. The defect-free and conformal nature of the films enables microbatteries with an electrolyte thickness as low as 70 nm, which withstand charge-discharge at 0.2 mA cm-2 for over 500 cycles. In Li/aLLZO/Li symmetric cells, plating-stripping at current densities up to 3.2 mA cm-2 shows no signs of lithium penetration. Finally, we show that the application of aLLZO as a coating on LLZO ceramic pellets significantly impedes the formation of Li dendrites.
Brain Tumor Discovery Using Image Preprocessing
Authors: Prem Jacob T  , Polakam Sukanya  , Thatiparthi Madhavi
Published: December 2020

The segmentation of attractive reverberation images assumes a critical job in therapeutic fields since it removes the required territory from the picture. Generally, there is no unique methodology for the segmentation of the picture. Tumour division from MRI information is a critical tedious manual undertaking performed by therapeutic specialists. In this paper, the Brain Cancer prediction System has been detailed. The framework utilizes PC based methods to recognize tumor squares and classify the tumour utilizing Artificial Neural Network. The picture preparing strategies, for example, histogram evening out, picture division, picture improvement, and highlight extraction, have been produced for the location of the cerebrum tumor in the MRI pictures of the malignant growth Detected patients. This paper focuses around another and exceptionally acclaimed algorithm for mind tumor division of MRI scan image by ANN and SVM algorithms to analyze precisely the locale of malignant growth as a result of its straightforwardness and computational proficiency. The MATLAB output will be shown in pc and furthermore observe the yield to insert framework utilizing wired communication. To the best of our insight into the zone of therapeutic big data analytics, none of the current work concentrated on the two data types. Contrasted with a few runs of the typical algorithms, the computation precision of our proposed algorithm achieves 94.8% with an assembly speed, which is quicker than that of the Decision tree disease hazard prediction.
Effects of long-term continuous monocropping on community structure and abundance of Pseudomonas spp. in cucumber rhizosphere
Authors: Gao H. , Rahman M. K. , Qiao P.L. , Wu F.Z. , Zhou X.G.
Published: December 2020

We grew cucumber in pots in greenhouse for 9-successive cropping cycles and analyzed the rhizosphere Pseudomonas spp. community structure and abundance by PCR-denaturing gradient gel electrophoresis and quantitative PCR. Results showed that continuous monocropping changed the cucumber rhizosphere Pseudomonas spp. community. The number of DGGE bands, Shannon-Wiener index and Evenness index decreased during the 3rd cropping and thereafter, increased up to the 7th cropping, however, however, afterwards they decreased again. The abundance of Pseudomonas spp. increased up to the 5th successive cropping and then decreased gradually. These findings indicated that the structure and abundance of Pseudomonas spp. community changed with long-term cucumber monocropping, which might be linked to soil sickness caused by its continuous monocropping.
PERAN PENGGUNAAN ANGGARAN DALAM PERUSAHAAN YANG MENGALAMI PERUBAHAN STRATEGIS
Authors: Sinarasri Andwiani
Published: December 2020

Organisasi yang berada dalam ketidakpastian lingkungan yang tinggi mendorong mereka untuk lebih ekstensif menggunakan sistem pengendalian strategik yang bertujuan untuk mempertahankan integrasi strategi. Simons (1987) menggambarkan bahwa interactive controls digunakan karena adanya ketidakpastian strategi dan mendukung manajemen untuk mengawasi timbulnya ancaman dan kesempatan. Sistem pengendalian akuntansi manajemen (termasuk proses penganggaran) memfasilitasi adaptasi terhadap faktor eksternalitas dengan cara memediasi antara ancaman dan kesempatan eksternal dengan organizational functioning (strategi atau struktur). Oleh karena itu, perusahaan diharapkan secara proaktif memformulasikan, merumuskan dan menyesuaikan strategi pasar sesuai dengan kondisi lingkungan (ancaman dan kesempatan). Hal ini diperkuat oleh Porter (1980) yang berpendapat bahwa perusahaan harus menyelaraskan strategi bisnis dengan kondisi lingkungan.Anggaran merupakan karakteristik utama sistem pengendalian akuntansi manajemen yang digunakan oleh manajemen sebagai sarana pengkoordiniran dan penyampaian prioritas-prioritas strategis, dan bersama-sama dengan sistem penghargaan, seringkali digunakan untuk memperkuat komitmen manajemen tingkat bawah terhadap prioritas-prioritas tersebut. Kata Kunci : Anggaran, perubahan strategi, kinerja perusahaan
Peran Akuntan Dalam Mewujudkan Unqualified Opinion Laporan Keuangan Pemerintah Daerah (LKPD) di Indonesia
Authors: Muhsin -
Published: December 2020

Kemampuan daerah mengelola uang negara, baik uang dari pusat maupun yang bersumber dari daerah itu, semakin hari malah semakin memburuk. Kenyataan tersebut secara ga,blang bisa kita ketahui dari makin sedikitnya laporan keuangan pemerintah daerah (LKPD) yang mendapatkan opini wajar tanpa pengecualian (WTP) dari badan pemeriksa keuangan (BPK). Opini Wajar Tanpa Pengecualian (WTP) tahun 2005, sebanyak 21 LKPD atau (6%) dari 350 LKPD, tahun 2006 sebanyak 4 LKPD atau (1%) dari 461 LKPD atau (3%) dari 434 LKPD. Semua itu menunjukkan dengan sangat terang-benderang, betapa rendahnya kompetensi daerah dalam mengelola keuangan negara. Dalam lima tahun terakhir, transfer dana APBN ke daerah meningkat lebih dari dua kali lipat, dari Rp 150,5 triliun pada 2005 menjadi Rp 309,8 triliun pada RAPBN 2010 Apakah yang akan terjadi bila jumlah uang negara yang harus dikelola terus membengkak, tetapi sebaliknya kemampuan untuk mengelolanya semakin merosot.Kata kunci : LKPD, unqualified opinion
KEY SUCCESS FACTOR GOOD GOVERNMENT GOVERNANCE SERTA PENGARUHNYA TERHADAP KINERJA PEMERINTAH (Survey pada Pemerintah Kabupaten Gunungkidul)
Authors: Lestiawan Handi Yuniar , Jatmiko Bambang
Published: December 2020

In this era, local government performance in Indonesia is weak because there are many abuse of authority everywhere, like corruption, collusion, and nepotism. Each of local government should apply the principles of good government governance in the government environtment, this is to improve performnace of local government. In this research good government governance principle contain transparancy, accountability, residents particpation, fairness, and responsibility. The purpose of this research is analyze dan explain the empirical evidence about the influence of transparancy, accountability, residents participation, fairness, and responsibility to the performance of local government. This research use primary data. Primary data derived from quistionnaire which share to employee of local government in Gunungkidul. This research involve 100 sample’s. The sample is determined by Slovin sampling method. Sample in this research derived from the employee of local government and Gunungkidul’s residents. Analitycal method use multiple regression. The result of this research is transparancy, accountability, and residents participation don’t have influence to the performance of local government, but fairness and responsibility have a positive and significant influence to the performance of local government.Keyword: Good Government Governance, performance of local government.
INDEPENDENSI, KOMITMEN ORAGNISASI, GAYA KEPEMIMPINAN, DAN PEMAHAMAN GOOD GOVERNACE TERHADAP KINERJA AUDITOR
Authors: . Sriyanto , Arifah Dista Amalia
Published: December 2020

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DESAIN E-BOOK DENGAN SOFTWARE FLIPBOOKMAKER UNTUK PEMBELAJARAN MATA KULIAH AKUNTANSI KEUANGAN DI STEKOM SEMARANG
Authors: Kholifah Siti
Published: December 2020

Tujuan penelitian ini adalah untuk mengembangkan produk e-book untuk pembelajaran mata kuliah akuntansi keuangan yang valid. Penelitian ini merupakan penelitian Research and Development. Penelitian pengembangan ini menggunakan modifikasi model 4D menjadi 3D dengan tahap define  (pendefinisian), design (perencanaan), dan development (pengembangan). E-book dengan software flopbookmaker terlebihdahulu dilakukan uji validasi oleh ahli media, ahli materi dan juga angket tanggapan mahasiswa. Diperoleh rata-rata penilaian validasi ahli materi 85,2%, validasi ahli media 89,2%, penilaian tanggapan mahasiswa 85,2%, Jadi media E-book layak digunakan dengan kategori sangat baik. Kata Kunci: Pengembangan, e-book, akuntansi keuangan
FAKTOR-FAKTOR YANG MEMPENGARUHIKEMAUAN MEMBAYAR PAJAK WAJIB PAJAK UKM
Authors: Kristiana Ida , Wibowo Agung S R. Ery
Published: December 2020

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang  mempenagruhi  wajib  pajak  UKM untuk membayar pajak. Penelitian ini menggunakan tiga variabel bebas yaitu pengetahuan dan pemahamanperpajakan, persepsi sistem perpajakan, dan kualitas pelayanan fiskus. Sedang variabel terikat dalam penelitianini adalah kemauan membayar pajak. Teknik sampling yang digunakan adalah teknik convenience  denganjumlah responden sebanyak 83 orang. Seluruh responden memiliki usaha dan terdaftar  pada  Dinas  KoperasiDan UKM di Kota Semarang. Analisis dalam penelitian ini menggunakan  analisis  linier  berganda  denganSPSS  17.0.  Hasil  analisis  menunjukkan  bahwa  variabel  pengetahuan   dan   pemahaman  perpajakan,persepsi sistem perpajakan, dan kualitas pelayanan fiskus memiliki pengaruh positis signifikan terhadap kemauan membayar pajak.
PENGARUH LATAR BELAKANG PENDIDIKAN, PENGETAHUAN AKUNTANSI PEMILIK, DAN UKURAN USAHA KECIL MENENGAH (UKM) TERHADAP PENERAPAN SAK-ETAP DI KOTA SEMARANG
Authors: Ari Prakoso Yogi , Sinarasri Andwiani , Sukesti Fatmasari
Published: December 2020

This research aims to prove evidence on the influence of owner’s educational background, owner’saccounting knowledge, and size of business towards the implementation of SAK ETAP on SMEs located inSemarang City used  quantitative method by using primary data. Used 83 samples with determination used theslovin formula. In this research used IBM SPSS for Windows 23 with three independent variables are owner’s educational background, owner’s accounting knowledge, and size of business and the implementation of SAKETAP as the dependent variable. The testing data used instrument test to consist of validity test and reliabilitytest, classic assumption test which consist of normality test, multikolinierity test, heteroskedastisity test, andautocorrelation, together with hypotesys test which covers f-test and t-test. The results show that the owner’s educational background do positive and not significantly effect on the implementation of SAK ETAP, owner’s accounting knowledge do positive and significantly effect on theimplementation of SAK ETAP, and size of business do positive and significantly effect on the implementationon the SAK ETAP partially, and taken tog ether simultaneously test do positive and significantly effect on theimplementation of SAK ETAP.
PENGARUH UKURAN PERUSAHAAN, DEBT DEFAULT, DISCLOSURE, OPINI AUDIT TAHUN SEBELUMNYA, DAN PERTUMBUHAN PERUSAHAAN TERHADAP PENERIMAAN OPINI AUDIT GOING CONCERN (PADA PERUSAHAAN MANUFAKTUR INDUSTRI DASAR DAN KIMIA DI BURSA EFEK INDONESIA TAHUN 2013-2017)
Authors: Rosiana Putri Yudia , . Hardiwinoto , . Alwiyah
Published: December 2020

Penelitian ini bertujuan untuk menguji pengaruh ukuran perusahaan, debt default, disclosure, opiniaudit tahun sebelumnya dan pertumbuhan perusahaan terhadap opini audit going concern pada perusahaanmanufaktur dalam bidang industri dasar dan kimia yang terdaftardi Bursa Efek Indonesia (BEI) 2013-2017.Sampel yang digunakan dalam penelitian ini adalah perusahaan manufaktur dalam bidang industri dasar dankimia yang terdaftardi Bursa Efek Indonesia berdasarkan kriteria yang telah ditetapkan.  Metode samplingyang digunakan adalah purposive sampling dan 30 data terpilih sebagai sampel, serta pengujian hipotesisdalam penelitian ini menggunakan analisis regresi berganda. Hasil penelitian ini menunjukan bahwa variabelindependen ukuran perusahaandanopini audit tahun sebelumnya secara parsial berpengaruh signifikan, tetapivariabel independen debt default, disclosure  dan pertumbuhan perusahaan tidak berpengaruh signifikanterhadap opini audit going concern. Dan hasil uji koefisien determinasi menunjukan angka sebesar 0,441, halini mengindikasikan bahwa secara simultan variabel independen ukuran perusahaan, , debt default,disclosure, opini audit tahun sebelumnya dan pertumbuhan perusahaan mampu menjelaskan variabeldependen opini audit going concern sebanyak 44,1% sedangkan sisanya sebesar 55,9% dijelaskan olehvariabel lain.
ARTERIAL HYPERTENSION AND COMORBIDITY (REVIEW)
Authors:   Samarkand State Medical Institute of the Republic of Uzbekistan, Agababyan Irina , Ziyadullaev Shukhrat , Ismailov Jamshid
Published: December 2020

Today, hypertension is considered by many authors within the framework of the manifestation of the metabolic syndrome. It has been established that in persons with hypertension in 60% of cases, various variants of MS are found. In addition, hypertension is a factor that reduces the quality of life of patients, especially those with comorbid pathology
THE CASES OF COMBINATION WITH ALLERGIC DISEASES AMONG A FAMILY WITH FAMILY-BRONCHIAL ASTHMA
Authors:   Samarkand State Medical Institute of the Republic of Uzbekistan, Okboev Toshpulat
Published: December 2020

A retrospective analysis of the medical history was carried out in 49 families of patients with bronchial asthma who were hospitalized in the Department of Pulmonology and Allergology SamGMO in 2010-2012.
ON ORTHOGONALIZATION OF BOUBAKER POLYNOMIALS
Authors: Khoso Nazeer Ahmed
Published: December 2020

In this work, we explore some unknown properties of the Boubaker polynomials. The orthogonalization of the Boubaker polynomials has not been discussed in the literature. Since most of the application areas of such polynomial sequences demand orthogonal polynomials, the orthogonality of the Boubaker polynomials will help extend its theareas of application. We investigate orthogonality of classical Boubaker polynomials using Sturm-Liouville form and then apply the Gram-Schmidt orthogonalization process to develop modified Boubaker polynomials which are also orthogonal. Some classical properties, like orthogonality and orthonormality relation and zeros, of the modified Boubaker polynomials, have been proved. The contributions from this study have an impact on the further application of modified Boubaker polynomials to not only the cases where classical polynomials could be used but also in cases where the classical ones could not be used due to orthogonality issue.
LATTICE BOLTZMANN PSEUDO-POTENTIAL MODELLING OF MULTIPHASE DROPLET PHENOMENA
Authors: Darmastono Thomas Ken , Jalaali Bahrul
Published: December 2020

The multiphase modeling of a droplet in a multiphase system is considered becoming a fundamental problem in fluid dynamics. A complex understanding of droplet behavior is critical to reveal a deeper insight into a more complex multiphase system. Droplet behavior studies are necessary to obtain a better understanding of solving multiphase problems in both the science and industrial aspect. The droplet behavior is characterized by a non-dimensional number such as the Eötvös number. In this study, numerical simulation was performed using the Lattice Boltzmann method. Parametric studies of Eötvös number was done. The parametric study of the Eo number is obtained using LBM. Based on the results obtained, it is concluded that the gravitational force influences the downwards rate of the droplet. Furthermore, the shape of the droplet during falling was depended on the Eo number as well. The higher Eo number means higher gravitational force, hence the velocity of the droplet is increasing as well as the reaction force of surface tension. This study is beneficial to give a deeper explanation of multiphase phenomena as well as contribute to the modeling of multiphase phenomena using an alternative numerical method of LBM.
A Midlife Dream: Bodily and Spiritual Integrity
Authors: NAZLIPINAR SUBAŞI Muzaffer Derya
Published: December 2020

Through centuries, the patriarchal construction of women’s bodies as disobedient, uncontrollable and as an evil source of disruption to the social order has formed the misogynist system that silences women’s voices and ignores their bodily experiences. Captivated in that system, women have been estranged from their bodies and from their sexualities, and in time, they acquire a split identity and self-understanding as they are merely considered silent and passive objects of male desire. Nevertheless, believing that the female body is an important site of struggle and resistance against the patriarchal structures, and an indispensable medium also through which a woman can articulate her repressed and ignored desire, Erendiz Atasü adopts to depict independent female characters in her works that experience their sexuality as an expression of power and free will. Considering those issues concerning women/women’s bodies and basing its argument on the theories of de(con)structing the phallocentric discourses, this study analyzes one of Atasü’s most sexually explicit works, A Midlife Dream, to unveil and question the relationship between female body and sexuality as well as proving that spiritual and sexual integrity is obtained merely through full body awareness.
Albert Camus’da Saçma Kavramı- Sisifos’u Mutlu Düşünmek
Authors: AYDINALP Esra Başak
Published: December 2020

İki dünya savaşına tanıklık eden Albert Camus’nün 1940’lı yıllarda kaleme aldığı Sisifos Söyleni yirminci yüzyılda modern insanlık durumunun “uyumsuzluğunu” ve insan varoluşunun çağlardan beri süregelen “saçmalığını ” ele alan en önemli denemelerinden biridir. Bu eserde Camus yaşamın anlamını, dünyanın insan karşısındaki kayıtsızlığı, bu kayıtsızlığın yarattığı uyumsuzluk, yabancılaşma ve anlamsızlık hissinin başkaldırı ile aşılmasını ele alır. Bu çalışmada amaç Albert Camus’nün Sisifos Söyleni’nde bütün detayları ile tanımladığı saçma kavramını derinlemesine incelemektir. Albert Camus, Sisifos Söyleni’nde yaşam/ölüm ikilemi arasında kalan insanın varoluş çabasını sorgular. Bu sorgulama dahilinde ölümlülüğü karşısında insanın yaşama uğraşının anlamsızlığı saçma kavramı ve duygusu ile açıklanır. Etik bir açıdan Camus, modern insanın yaşam deneyiminde kendisini sürekli tekrar eden, amaçsız ve tekdüze varoluş şeklinin neden olduğu uyumsuzluk halinin, insanın kendine yabancılaşmasının; direniş ve başkaldırı ruhu ile nasıl mutlu bir varoluş olarak tasarlanabileceğini Sisifos Söyleni’nde uyumsuz kahramanın yaşama azmi ve tutkusu ile örnekler.
Novel Flexible Piezoresistive Sensor based on 2D Ti3C2Tx MXene
Authors: Sobolciak Patrik , Sadasivuni Kishor Kumar , Tanvir Aisha , Krupa Igor
Published: December 2020

Stretchable and wearable strain-sensing devices are appropriate for motion detection, biomedical monitoring, human-machine interaction. These pressure sensors are working based on numerous electrophysical phenomena's such as piezoelectric, capacitive and piezoresistive reactions towards mechanical stretching. Piezoresistive sensors are highly favored due to their features like high sensitivity, fast response, easy fabrication and low energy requirement. They are generally fabricated using a suitable polymeric matrix and electrically conductive fillers, such as graphite, graphene or carbon nanotubes. MXenes are a relatively new family of (2D) transition metal carbides, nitrides or carbonitrides, produced by the selective chemical etching of “A” from MAXphases, where M is a transition metal, A is a group IIIA or IVA element and X is C or N. These nanomaterials are first reported in 2011 by the Gogotsi and Barsoum groups. These materials have received tremendous attention from the scientific community due to their excellent physiochemical properties, electrical conductivity and hydrophilicity. Herein, we report the preparation, characterization and piezoresistive individualities of semiconductive, electrospun mats composed of copolyamide 6, 10 and Ti3C2Tx. We observed that the relative resistance of the sensor increased with an increase in the Ti3C2Tx content, and the materials with higher electrical conductivity showcased a significantly higher sensitivity to applied pressure until reaching the percolation limit (font size can be increased).
Soil Respiration Variation under the Canopy of Dominant Tree Species across different seasons in Temperate Forest
Authors: Rawat Monika
Published: December 2020

Soil respiration is defined as the production of carbon dioxide when soil organisms are active. It is an important process in the ecosystem and has direct influence on climate change. Therefore understanding it under different vegetation types is an essential goal in soil science. The major sources which effect the soil respiration rate are plant roots, the rhizosphere, microbes and soil fauna and these sources are control by various factors like temperature, moisture, nutreint content and oxygen in the soil. Soil respiration rate is important for understanding soil biological activity, nutrient cycling, soil microbial biomass, soil organic matter and its decomposition.Therefore soil respiration was studied under the canopy of ten dominant tree species of temperate forest. Our study determined that highest soil respiration was under the canopy of Eunonymous pendulus (EP) i.e. 20.01 μmolm−2 s−1 and across season it was high during the rains.
Modern concepts of the osteogenic potential of mesenchymal stem cells and the creation of bioengineering structures for bone tissue repair
Authors: Zhernasechanka H. A.
Published: December 2020

The following review summarizes the latest studies on in vitro osteogenic mesenchymal stem cell differentiation and selection of scaffolds that can maintain the viability and functional activity of these cells for bone tissue repair. In the last time, there have been investigated a lot of issues such as the stimulation and development osteogenic differentiation of MSCs, the growth factors – inducers of osteogenesis in MSCs, the creation of 3D constructions of cells in different scaffolds. A deeper understanding of the osteogenic differentiation mechanisms can result in the novel therapeutic opportunities of bone disease treatment. Special attention is given to materials for scaffold designs and template–cell interactions, which is of great importance for the structuring and functioning of an engineered tissue.
Cekaman Severe Drought Stress Influences the Success of Madura Tangerine Flower InductionKekeringan Berat Mempengaruhi Keberhasilan Induksi Bunga Jeruk Keprok Madura
Authors: Rahayu Resa Sri , Poerwanto Roedhy , Efendi Darda , Widodo Winarso Drajad
Published: December 2020

Induksi bunga jeruk keprok di luar musim melalui cekaman kekeringan merupakan salah satu upaya memenuhi ketersediaan buah jeruk keprok sepanjang tahun. Tingkat cekaman kekeringan yang dapat menginduksi bunga memiliki ambang batas tertentu sehingga cekaman yang terlalu berat dapat mempengaruhi keberhasilan induksi bunga. Penelitian ini bertujuan membuktikan bahwa cekaman kekeringan yang terlalu berat dapat mempengaruhi keberhasilan induksi bunga jeruk keprok dataran rendah varietas Madura. Penelitian dilaksanakan di Kebun Percobaan Tajur PKHT-IPB dengan ketinggian ± 300 mdpl dari bulan Maret-Oktober dan dirancang dengan Rancangan Acak Kelompok (RAK) satu faktor yaitu tingkat cekaman kekeringan dengan tiga taraf: tanpa cekaman kekeringan sebagai kontrol (pengairan rutin dengan 100% kadar air kapasitas lapang), cekaman kekeringan 50% kadar air kapasitas lapang (tanpa pengairan sampai 50% kadar air kapasitas lapang) dan cekaman kekeringan 40% kadar air kapasitas lapang (tanpa pengairan sampai 40% kadar air kapasitas lapang). Hasil penelitian menunjukkan bahwa kadar air 50% dan 40% dari kapasitas lapang tidak menginduksi bunga jeruk keprok Madura yang dibuktikan dengan kadar giberelin yang sangat tinggi. Kadar air 50% dan 40% dari kapasitas lapang terlalu rendah sehingga tanaman mengalami cekaman kekeringan berat dan mengganggu proses induksi bunga. Cekaman kekeringan berat tersebut ditandai dengan potensial air daun dan tanah yang tinggi, kadar prolin daun tinggi, kerapatan stomata menurun, dan daun menggulung.

Kata kunci: jeruk keprok dataran rendah, kadar air kapasitas lapang, luar musim, Rancangan Acak Kelompok (RAK), rewatering
A Historical and Mathematical Study on Continuum - Focusing on the Composition and Infinite Division -
Authors:   The Korea Society Of Educational Studies In Mathematics, Baek Seungju , Choi Younggi
Published: December 2020

This study conducted historical and mathematical analyses of the composition of continuum and infinite division. Regarding the results of the historical analysis, first, it can be seen that mathematicians struggled with the problems related to Zeno’s “paradox of plurality” in the composition and infinite division of the continuum. Second, historically, infinite small appeared frequently. Third, the problem of continuum, which was a geometric problem, was not explained by geometry alone, and mathematical answers to this problem became possible after the straight line became homomorphic with the real set, following the arithmetization of mathematics. Through mathematical analysis, Zeno's “paradox of plurality”, which includes questions about the composition and infinite division of a continuum, could be explained depending on the uncountability of real numbers and the countable additivity of Lebesgue measure.
In addition, it was confirmed that it is inappropriate to divide a straight line to a point. The historical and mathematical analyses of this study suggest that students may have cognitive difficulties when dealing with the composition and infinite division of a continuum in relation to area, volume, and integral in school mathematics. The continuum is a concept closely related to the limit and calculus of school mathematics, and the historicalㆍ mathematical analysis of this study could serve as a foundation for teaching and learning plans of limits and calculus.
Investigating the Possibility of Performing Algebraic Generalization Based on the Analysis of Problem Solving on Near/Far Generalization of 6th Graders
Authors:   The Korea Society Of Educational Studies In Mathematics, Lim Miin , Chang Hyewon
Published: December 2020

Students who have learned arithmetic in elementary mathematics would learn algebra in middle schools in earnest. So, the transition from arithmetical thinking to algebraic thinking is an important success factor for algebra learning. Therefore, in this study, 64 sixth graders solved the problems of near generalization and far generalization concerning the generalization of some figure patterns. Subsequently we analyzed their problem solving. As a result of the analysis, several cases of students having difficulties in performing algebraic generalization were identified. Through the discussion of the research results, several pedagogical implications were drawn to support the transition from arithmetical thinking to algebraic thinking in elementary school students.
Audit of the effect of non-nasal specific scoring on the Postoperative SNOT22 questionnaire
Authors: Samir Gendy
Published: December 2020

The Sino-nasal outcome test (SNOT22) has been widely adopted in clinical practice and has been declared as the most suitable sinonasal outcome scoring system. It is simple disease specific encompassing 22 symptoms reflecting health burden of the rhino- logical patients. Each item quantifies symptoms severity from 0(no problem) to 5 (worst symptom). The sum of each item results in a maximum score of 110. High score indicates poor outcome.
Premature ovarian insufficiency in children: Etiology, clinical management and treatment
Authors: Ke Yuan , Chunlin Wang
Published: December 2020

Premature ovarian insufficiency (POI) is a rare disease, especially in children and adolescents. It was previously called premature ovarian failure (POF). It can be manifested as delayed puberty, primary or secondary amenorrhea that occurred before the age of 40 years with no less than two abnormal serum sex hormones (low estrogen and high gonadotropin). It is reported that the incidence rate is 1% at the age of 40 years and 0.01% at the age of 20 years. Although the disease usually occurs in middle-aged and elderly women, clinical practice in recent years has shown that it has also been found in adolescents and even children. It is generally believed that the etiology of POI includes genetic factors, immune factors, and iatrogenic factors. So far, several genetic mutations that may cause POI have been found clinically, but the etiology of 90% of POI is still unknown. In recent years, the incidence of POI in children and adolescents has increased, and there are more urgent requirements for its early diagnosis, treatment, and clinical management. Based on this, this article will mainly review the research progress of the etiology, treatment, and clinical management of POI in children and adolescents.
Improving the Methodology for Calculating the Average Turnover of Gondola Cars of an Iron and Steel Plant
Authors: Popov A. T. , Khmelev A. S.
Published: December 2020

The average daily mileage of a wagon, its productivity and turnover determine the level of efficiency of rolling stock use. The car turnover is calculated and normalized not only for the fleet as a whole, but also for each type of rolling stock, for a particular region and road, depending on the nature of the transportation work. Accelerating car turnover increases its productivity and increases profit of an operator company. At the same time, its decrease negativ ely affects the capacity of the infrastructure, entails an increase in the cost of shunting and train work, which means that it will increase the cost of transportation. In modern conditions, turnover is determined for each participant in transportation in accordance with his area of responsibility. For an iron and steel plant, the use of an optimal methodology for recording the time spent by a wagon on its tracks allows us to adequately assess this important quality indicator, as well as to monitor its change as a result of introduction of new technologies for transport maintenance of workshops, reconstruction of station layout and optimization of the transportation process. The objective of the study is to improve the methodology for determining car turnover on access roads of a metallurgical enterprise for universal rolling stock in the context of dual operations. The authors use general scientific methods, mathematical methods, comparative analysis. This article presents the main provisions of the methodology, which will allow determining turnover of gondola cars subject to a single or dual operations in the form of a single indicator which is average weighted car turnover.
The Concept of Development and Implementation of High-Speed Transport
Authors: Alexeev V. M. , Vaganov A. V. , Katina M. V.
Published: December 2020

The article discusses the issues of implementation and organization of high-speed transport. The objective of the article is to consider possible options for implementing highspeed (HS) motion systems using the principle of magnetic levitation, which will ensure high speeds for delivery of goods and carrying people over long distances. To achieve this objective, it is necessary to develop an engine and technical solutions for design of HS rolling stock, make decisions on energy supply infrastructure and the HS track, address safety issues and new control systems considering the state of the infrastructure and its design elements. The article discusses several options for implementation of high-speed transport systems, differing in the power supply system, current collection and track based on the magnetic levitation approach. An original approach is proposed in implementation of magnetic levitation transport using the technology of electromagnetic guns designed to implement traction forces of a magnetic levitation vehicle. The advantage of this approach is that it opens the possibility of maneuvering for the vehicle while driving. This allows to abandon switch turnouts, now significantly limiting the use of magnetic levitation transport. A mathematical model describing interaction of an electromagnetic gun and supermagnets located on the track is considered. In constructing the model, methods of the theory of electromagnetic field and interaction of magnetic bodies were used, and when constructing a model of interaction of rolling stock with a magnetic track, methods of mathematical algebra and the Cauchy theorem were used. The article discusses various principles of organization of movement using the magnetic levitation for urban, suburban, and intercity transport.
Comparison of Forecasting Methods for Intercity Passenger Flows for Various Modes of Transport
Authors: Makutsky N. A. , Fadeev M. S. , Chistyakov P. A.
Published: December 2020

The article is devoted to methodological features of forecasting intercity passenger flows under the conditions of transformation of the transport system of Russia, namely, the emergence of a new type of rail transport which is high-speed rail. The objective of the article is to present the authors’ methodology for forecasting passenger flows and to prove its higher efficiency relative to the methods used in Russia today. The article considers the historical aspect of forecasting passenger flows, analyzes strengths and weaknesses of existing approaches to forecasting and modelling passenger flows. The authors argue that it is impossible to simulate the number of trips with changes in transportation parameters only on the basis of patterns identified by retrospective data series (the most common approach to forecasting passenger flows in Russia). The article proposes an alternative methodology based on the calculation of passenger’s total costs of a trip, which depend on cost of travel, loss of time, frequency of departure of vehicles and their comfort, as well as considering the dynamics of key social-economic indicators. The technique allows minimizing measurement errors arising from the lack of primary information about some types of passenger transport, as well as calculating the induced demand for trips arising as a result of improved transportation characteristics. The authors identified and expressed in quantitative terms the main factors of redistribution of passenger flows to newly introduced types of transport. The article discusses the experience of forecasting passenger flow according to the proposed method at the example of four itineraries where movement of high-speed trains of Lastochka type started. The forecasted results are compared with the actual volumes of transportation, on the basis of which conclusions are drawn about the effectiveness of the forecasting method and its applicability in modern realities of the Russian transport system. The advantages and disadvantages of the proposed approach to forecasting passenger traffic, as well as the possibilities of its implementation and further development in Russia are identified.