bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect Of Technology Characteristics In The Continued Use Of Charity Crowdfunding Platforms Through Trust And User Satisfaction
Authors: Almuntaha Eska , Rahmawati Nur
Published: June 2023

This research's objective is to examine the effect of technological characteristics on trust and satisfaction in using a charity crowdfunding platform so that the user will reuse the platform. The use of technology in excellent and sustainable online donation fundraising requires the fulfilment of technological characteristics. A study by Bhattacherjee (2001)) stated that continued use influences information technology's success. Another significant area in information systems research is user satisfaction because it is an essential factor in measuring the use and success of an information system (Bailey and Pearson, 1983; Ives et al., 1983; Doll and Torkzadeh, 1988; Delone and McLean, 1992 in Roca et al., 2006). This study used the purposive sampling method and tested the hypothesis using the Structural Equation Model (SEM). This research proves that trust affects the satisfaction of using a charity crowdfunding platform, but not with technological characteristics. Meanwhile, users' satisfaction influences continued use but not trust.

Keywords: Technology Characteristics, Continued Use, User Satisfaction, User Trust, Charity Crowdfunding Platform.
The Influence Of Political Connections And Capital Intensity Ratio On Effective Tax Rate: Moderated by Profitability
Authors: Fresti Wulandari Fanneisa , Lutfi Ardhani
Published: June 2023

The objective of the research was to determine dan analyze the influence of political connection dan capital intensity ratio on effectivetax rate as a moderating variable on profitability. The research method used is a quantitative method with sampling using purposivesampling. The research sample is 72 mining sector company data listed on the Indonesia Stock Exchange for the 2018-2021 period. The research analysis uses path analysis with the help of the SEM-PLS 3.3 application The results of the study show that political connections affect the effective tax rate. The capital intensity ratio does not affect the effective tax rate. While profitability can moderate political connections and profitability are not able to moderate the capital intensity ratio on the effective tax rate. This research is expected to contribute to providing input dan an overview regarding tax avoidance so that it can help stakeholders such as the government to make decisions dan policies on tax regulations that will be applied.
TANGKAP KELONG SEBAGAI KEARIFAN LOKAL DALAM MENINGKATKAN KEHIDUPAN SOSIAL EKONOMI MASYARAKAT PULAU SERAYA
Authors: Yanti Fitri , Sinar Sinar
Published: June 2023

Tujuan penelitian ini adalah untuk mengetahui tangkap Kelong sebagai kearifan lokal dalam meningkatkan kehidupan social ekonomi masyarakat yang ada di Pulau Seraya Kelurahan Batu Legong Kecamatan Bulang Kota Batam. Jenis penelitian ini adalah kualitatif deskriptif. Data penelitian diperoleh dari wawancara, observasi, dokumentasi Analisis data dilakukan melalui wawancara dengan informan diantaranya nelayan, tokoh masyarakat, perangkat desa dan masyarakat. Teknik analisis data menggunakan model interaktif dari Miles and Huberman yaitu data reduction (reduksi data), data display (pengajian data), dan concluston drawing/verification. Temuan penelitian ini menjelaskan bahwa Tangkap Kelong yang ada di Pulau Seraya Kelurahan Batu Legong Kecamatan Bulang Kota Batam merupakan kearifan local daerah ini yang mempunyai keunikan terutama dari pelaksanaan dan peralatannya. Tangkap Kelong hanya dilaksanakan pada saat tahun baru imlek dan berlangsung selama 1 minggu dengan 2 sampai 3 tarikan dan diikuti dengan acara kenduri. Tangkap kelong ini dapat mempengaruhi kehidupan sosial ekonomi masyarakat, diantaranya semakin meningkatnya rasa kebersamaan dalam bentuk gontong royong, meningkatnya pendapatan sehingga kehidupan masyarakat di Pulau Seraya lebih sejahtera.
HASAN TIRO: SEJARAH ACEH SEBAGAI PIJAKAN IDEOLOGI DALAM ACEH MERDEKA
Authors: Sari Monika
Published: June 2023

Aceh merupakan salah satu derah yang mendapatkan otonomi khusus dari Pemerintah Pusat. Aceh dengan sejarah panjangnya yang menjadikan Aceh sebagai wilayah yang makmur secara sumber daya Alam terutama lada. Letak yang strategis dan memiliki daya pikat dalam hal perdagangan menjadikan Aceh sebagai Bandar perdagangan Internasional yang banyak dikunjungi oleh para pedagang asing baik dari Cina, Gujarat, India, Arab dan lain sebagainya. Hal ini menjadikan Aceh sebagai wilayah yang memiliki tingkat multikulturalisme yang tinggi dalam kehidupan sosialnya. Namun ada beberapa factor yang menjadikan ketidakpusan Aceh terhadap Pemerintah Pusat. Hasan Tiro bangkit menjadi tokoh yang menggerakan Aceh Merdeka (GAM). Metode penelitian ini menggunakan metode studi literature. Dengan menggunakan berbagai literature untuk menelaah pemikiran Hasan Tiro dalam Ideologi Gerakan Aceh Merdeka (GAM). Hasil penelitian yakni Pertama, Kesadaran masyarakat bahwa Aceh dalam sejarah adalah sebuah negara berdaulat jauh sebelum Indonesia ada. Kekuasaan Aceh meliputi hampir seluruh Sumatera dan negara Malaysia sekarang ini. Kekuasaan yang demikian besar sungguh tidak layak diturunkan menjadi hanya sebagai sebuah daerah dalam negara lain. Kedua, timbulnya penentangan terhadap Jakarta. Menurut masyarakat Aceh, sinkronisasi pemikiran Hasan Muhammad di Tiro sesuai dengan kondisi Aceh. Potensi alam dan kekhasan budaya Aceh dikhianati oleh Jakarta
Pengaruh Return On Equity, Debt to Equity Ratio, Debt to Equity Ratio, Earning Per Share Terhadap Harga Saham
Authors: Onoyi Nona Jane , Yantri One , Windayati Diana Titik
Published: June 2023

This research aims to determine the effect of Return On Equity, Debt to Equity Ratio, Net Profit Margin, Earning Per Share on Stock Prices in LQ45 companies listed on the Indonesia Stock Exchange for the 2016-2019 period. The research method uses a quantitative approach. The data used in this research is secondary data. The sample selectionis done by purpose sampling obtained 31 samples of companies. The results showed that partially ROE and EPS variables had a significant effect on stock prices. While the DER and NPM variables partially have no significant effect on stock prices. Simultaneously ROE, DER, NPM and EPS variables have a significant effect on stock prices.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUTUSAN NASABAH
Authors: Juhardi Juhardi , Susanti Ervin Nora
Published: June 2023

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis pengaruh faktor-faktor yang mempengaruhi terhadap keputusan nasabah. Teknik yang digunakan adalah metode survei, teknik pengumpulan data dalam penelitian ini dilakukan dengan menggunakan kuisioner dengan skala Likert. Populasi penelitian adalah nasabah priorotas Bank Syariah Indonesia KCP Batu Aji sebanyak 96 nasabah. Sampel sebanyak 26 responden, dengan Teknik sampling sensus. Hasil penelitian Pelayanan berpengaruh signifikan terhadap keputusan nasabah. Produk berpengaruh tidak signifikan terhadap keputusan nasabah. Promosi berpengaruh signifikan terhadap keputusan nasabah. Pelayanan, Produk, dan Promosi berpengaruh signifikan terhadap keputusan nasabah.
PENGARUH KOMITMEN, PRODUKTIVITAS, ORGANIZATION CITIZENSHIP BEHAVIOR, DAN PELATIHAN TERHADAP KINERJA PERSONIL
Authors: Rahman Sarif , Nasrul Herni Widiyah , Tarigan Petra Paulus
Published: June 2023

Tujuan penelitian ini untuk mengetahui dan menganalisis pengaruh Komitmen, Produktivitas, Organization Citizenship Behavior, dan Pelatihan Terhadap Kinerja Personil Polsek Tanjungpinang Barat. Sampel yang digunakan dalam penelitian ini berumlah 30 orang. Pertanyaan diberikan dengan menggunakan Koesioner yang didistibusikan melalui Purposive sampling dengan menggunakan metode analisis data yang diguakan adalah uji validitas, uji reliabilitas, uji asumsi klasik, dan analisis regresi berganda. Hasil penelitiannya adalah komitmen berpengaruh positif dan signifikan terhadap kinerja personil, produktivitas berpengaruh positif dan signifikan, organization citizenship behavior berpengaruh terhadap kinerja personil, pelatihan berpengaruh positif dan signifikan terhadap kinerja personil, komitmen, produktivitas, organization citizenship behavior, dan pelatihan terhadap kinerja personil.
ANALISIS MANAJEMEN RESIKO KEUANGAN BUMN TERHADAP PERTUMBUHAN LABA
Authors: Fitri Hyuliana , Oktavianti Oktavianti
Published: June 2023

Penelitian ini dilakukan untuk mengetahui dan menganalisis: (1) Retun  On Equity (ROE) berpengaruh terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (2) Return  On Investment (ROI) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (3) Cash Ratio berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (4) Current Ratio berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (5) Collection Periods (CP) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (6) Perputaran Persediaan (PP) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (7) Total Asset Turn Over (TATO) berpengaruh terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (8) Total Modal Sendiri terhadap Total Aset (TMS thd TA) berpengaruh terhadap terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018 (9) Return  On Equity, Return  On Investment, Cash Ratio, Current Ratio, Collection Periods, Perputaran Persediaan, Total Asset Turn Over, dan Total Modal Sendiri terhadap Total Aset secara simultan berpengaruh terhadap Pertumbuhan Laba perusahaan BUMN periode 2014-2018.
PENGARUH PROMOSI DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN
Authors: Sutrayani Sutrayani , Anggraini Dini
Published: June 2023

Penelitian ini bertujuan untuk menilai seberapa besar pengaruh Promosi dan Harga Terhadap Keputusan Pembelian. Jenis penelitian yang digunakan adalah penelitian explanatory kuantitatif. Data yang diolah adalah hasil dari penyebaran kuesioner kepada pelanggan PT. Kumala Celebes Motor Mazda Makassar.Teknik analisis data yang digunakan dalam penelitian ini adalah regresi linear berganda. Untuk menjelaskan deskripsi penelitian yang berkaitan dengan hipotesis dengan menggunakan analisis: Uji Validitas, Uji Reliabilitas, Uji t (Parsial). Berdasarkan hasil analisis data untuk uji signifikansi uji t menunjukkan bahwa variabel Promosi (X1) dan Harga (X2) secara parsial berpengaruh positif dan signifikan terhadap Keputusan Pembelian Konsumen Pada PT. Kumala Celebes Motor Mazda Makassar.
PENGARUH GREEN PRODUCT TERHADAP MINAT BELI ULANG KONSUMEN MELALUI GREEN ADVERTISING
Authors: Handoko Harry , Arifin Ahmad
Published: June 2023

Penelitian ini dilakukan untuk menguji pengaruh Green Product Reusable Color Changing Cups terhadap minat beli ulang konsumen Starbucks melalui Green Advertising yang ada di akun Instagram @starbucksindonesia. Metode penelitian yang digunakan adalah metode penelitian deskriptif kuantitatif dan analisis jalur melalui kuesioner yang dibagikan kepada 80 responden yang merupakan followers Instagram @starbucksindonesia yang menggunakan Reusable Color Changing Cups di Sahid Sudirman Center. Hasil penelitian menunjukan bahwa Green Product berpengaruh positif terhadap minat beli ulang yang dimediasi oleh Green Advertising di Instagram @starbucksindonesia. Starbucks harus terus mempertahankan Green Product yang diusung dan ditunjang untuk terus berinovasi dalam menghasilkan produk yang berkualitas dan ramah lingkungan, didukung juga dengan iklan yang menarik konsumen melalui media yang potensial, seperti Instagram.
PENYUSUNAN ANALISIS JABATAN DAN ANALISIS BEBAN KERJA PADA SEKSI PENANGANAN FAKIR MISKIN PEDESAAN DI DINAS SOSIAL PROVINSI SULAWESI SELATAN
Authors: F. Tonapa Jessica , Az-zahra Malik Reinita
Published: June 2023

Terdapat sebuah kekeliruan dalam Analisis jabatan dan analisis beban kerja pada Dinas Sosial Provinsi Sulawesi Selatan. Analisis jabatan dan analisis beban kerja juga masih menggunakan format lama. Berdasarkan permasalahan tersebut, maka penelitian ini bertujuan untuk menyempurnakan analisis jabatan dan analisis beban kerja melalui rancangan sesuai dengan Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Nomor 1 Tahun 2020 pada Seksi Penanganan Fakir Miskin Pedesaan di Dinas Sosial Provinsi Sulawesi Selatan. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif. Metode analisis data yang digunakan adalah reduksi data, penyajian data, dan verifikasi data. Hasil penelitian ini adalah karya analisis jabatan dan analisis beban kerja yang memuat 17 (tujuh belas) butir informasi jabatan dibuat dengan berdasarkan pada Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Republik Indonesia Nomor 1 Tahun 2020 tentang Pedoman Analisis Jabatan dan Analisis Beban Kerja.
INOVASI DESAIN KEMASAN PRODUK RUMAH MAKAN BONELO
Authors: Muhammad Ashar , Kalsum Ummi
Published: June 2023

Industri kuliner saat ini berkembang pesat di Indonesia salah satunya rumah makan yang mudah ditemui dengan berbagai hidangan makanan dan minuman.  Semakin berkembang bisnis rumah makan menyebabkan tingginya tingkat persaingan menuntut rumah makan melakukan inovasi agar mampu bertahan dalam dunia bisnis. Desain kemasan merupakan strategi yang dapat digunakan perusahaan untuk bersaing dalam dunia bisnis. Rumah Makan (RM) Bonelo merupakan salah satu rumah makan yang ada di Kota Makassar. RM Bonelo memiliki permasalahan pada kemasan produk yang dimana kemasan makanannya kurang menarik dan gampang rusak sehingga pada penelitian menghasilkan output sebuah inovasi desain kemasan produk. Pada penelitian ini menggunakan metode kualitatif dengan metode pengumpulan wawancara dan observasi. Dengan adanya inovasi kemasan produk pada kemasan RM Bonelo dapat meningkatkan penjualan dan keuntungan.
Applications of evidence synthesis in chemical health risk assessment
Authors:   , Scholten Bernice Jannigje Wilhelmina
Published: June 2023

This thesis aimed to combine all available evidence within and across evidence streams, i.e. evidence synthesis, to strengthen chemical risk assessment. The evidence considered was published data of the following evidence streams: epidemiologic studies, molecular epidemiology studies, animal studies and mechanistic assays. For the purpose of evidence synthesis, advanced statistical and biological informed tools and approaches were used including meta-analysis, meta-regression, text mining, systematic reviews, systems biology, physiological based kinetic (PBK) models, and Bayesian inference. Most work performed in this thesis is on two exemplary data rich chemicals: benzene and diisocyanates. The case-studies of this thesis illustrate that human biomonitoring studies can be a valuable source of information for both enhancing exposure assessment and hazard characterization. Tooling such as text mining and network visualization tools can help to make evidence identification for hazard identification more efficient. And evidence from human (epidemiology and biomonitoring) and animal studies can also be combined together, but this does require a large number of assumptions. The chapters in this thesis demonstrate that a wide range of interdisciplinary approaches are required to be able to integrate data, for it to become optimally useful for chemical risk assessment. The methods and tooling in this thesis are mostly applied to chemicals for which a large amount of data is known. In the Discussion chapter of this thesis, suggestions are given for approaches that can be used for chemicals for which only little information is known, possibly in conjunction with the new scientific approaches described in the other Chapters of this Thesis.
Novel Transcatheter Approaches to Tricuspid Regurgitation
Authors: Fouarge Noémie
Published: June 2023

AT the European Association of Percutaneous Cardiovascular Interventions (EuroPCR) Congress 2023 in Paris, France, a pertinent session dove into novel transcatheter approaches to valvular heart disease, including tricuspid regurgitation (TR) and aortic stenosis. Experts from different institutions across the world explored a range of novel devices to treat these conditions.
Classification of the Usage of Digital Supporters in Marriage Migrant Females and the Comparison of Their Characteristics
Authors:   The Korean Society of Culture and Convergence, Ko Myoungjee
Published: June 2023

The purpose of this study is to classify latent classes according to the use of digital assistants by married migrant women, identify the influencing factors of each latent class, and compare the level of social capital and digital informatization for each class. As a result of LPA, it was classified into three types: 'high-utilization group', 'middle-utilization group', and 'low-utilization group'. In addition, as factors affecting the latent classes using R3STEP, age, education level, regional size, duration of residence, and country of origin variables were affected. As a result of examining whether there was a difference in the level of social capital and digital informatization between each type through DU3STEP, there was a significant difference in social capital in all three groups, and the level of digital informatization was different between the low-utilization group and the rest of the groups. This study is significant in that it provides a basis for clearly recognizing the factors affecting the digital information gap of marriage migrant women and establishing appropriate policies.
The Effect of Comprehensive Thinking Tendency, Perceived Usefulness, and Artificial Intelligence Ethical Risk Perception on Attitude and Intention to Use Artificial Intelligence Technology
Authors:   The Korean Society of Culture and Convergence, Guo Juntao , Jun Jong Woo
Published: June 2023

This study verifies AI attitudes and usage intentions through three levels of thinking tendency, usefulness, and AI ethical risk perception. The results show that the three variables have a positive impact on AI attitudes, and AI ethical risk perception has a positive impact on use intention. And confirmed the mediation effect of attitude. Provide theoretical and practical significance for the future development of artificial intelligence.
Suicide and Violent Behavior in Psychotic Inpatients
Authors: Vijayen Jayatamarai , Hui Koh Ong , Siddiq Amer
Published: June 2023

Introduction: This study compares the association between psychosis, suicide, and violent behavior in patients admitted and discharged from the psychiatric ward. Methods: This study used a cross-sectional design. The experimental study was done with all the psychotic patients fulfilling the inclusion criteria upon admission and discharge from a teaching hospital in Malaysia. The study was conducted for a duration of five months from March to July 2022. Psychotic patients with various diagnoses based on the DSM-5 were interviewed. PANSS score was used upon admission and discharge to look at the severity of psychosis. Suicide behavior was assessed using SBQ-R while violent behavior was assessed using MOAS. Sample size consist of 100 consecutive psychotic patients. Results: Suicide behavior was noted to be present in patients no matter the severity of psychosis. Upon discharge, even after the improvement of psychosis, patients were still at risk of suicide behavior. Violent behavior was noted to be present in most of the patients in the PANSS group (except for the moderately ill patients) no matter the severity of psychosis. However, upon discharge from the psychiatric ward, we can see that all patients went home not having violent behavior. This concludes that, when psychosis improves, the risk of having violent behavior reduces. Conclusions: Further exploration on the reasons of why suicide behavior persists in psychotic patients has to be done by clinicians. It is dangerous for clinicians to make assumptions that psychotic patients presenting with suicide behavior are solely due to the psychosis.
Clinical Characteristics of Outpatient Adolescents Undergoing Ongoing Psychotherapy in a Greek Tertiary Hospital from June 2016 to December 2019
Authors: Voultsos P , Tsamadou E , Demertzi E
Published: June 2023

Background: Adolescents with mental disorders often have difficulty engaging in ongoing treatment. Dropout from treatment is common.

Aim: This paper aims to explore the clinical characteristics of a cohort of adolescents with mental disorders who were stably and actively undergoing psychotherapy over a relatively long period of time (for at least four months).

Method: A purposive single-center cross-sectional cohort survey was conducted from June 2016 to December 2019. The sample of the study (N=50) was recruited from the Child and Adolescent Psychiatry outpatient setting of a large tertiary hospital of Thessaloniki, the second largest city in Greece. An intelligence test (Wechsler Intelligence Scale for Children, WISC III) and a self-report measure of depression (Beck Depression Inventory, BDI II) were used. All the participants underwent a rigorous clinical assessment of their mental health status in both initial and ongoing psychotherapy. The initial diagnosis was reconfirmed during the course of therapy. Mental disorders were defined and diagnosed using the ICD-10 (1992) (International Classification of Diseases).

Results: The largest percentage of adolescents (44.9%) were found to suffer from mood (affective) disorders, while 20.4% suffered from neurotic disorders. We also found high prevalence of pessimism (32.7%), reduction of energy (28.6%) and difficulty in concentration (32.7%). A total of 22.4% of adolescents reported sleep disorders. A limited interest in sex was noted, which was in contrast with international and Greek data, where interest and experimentation around sex seems to preoccupy a high percentage of adolescents. Furthermore, sleep disorders, either as a symptom of an underlying disease or as an independent clinical condition, seem to preoccupy adolescents, and this may be a motive for them to seek treatment.

Conclusion: For the most part, the findings of this study were consistent with the findings of prior studies; however, previous studies did not exclusively include adolescents engaging in ongoing psychotherapy. As we identified some inconsistencies with prior studies related to interest in sex and sleep disorders, further research is recommended for the investigation of possible correlations between these findings and ongoing psychotherapy engagement rates. Note, however, that the findings in this study are not representative of adolescents in Greece due to the fact that the used sample was not representative.
LEGAL CONSEQUENCES OF CHILDREN OUTSIDE OF MARRIAGE AFTER CONSTITUTIONAL COURT DECISION NUMBER 46/PUU-VIII/2010
Authors: Hamid Asrul , Fakhyadi Defel
Published: June 2023

Civil Code, Law Number 1 of 1974 concerning Marriage, and the Compilation of Islamic Law (KHI)is a legal rule that regulates the regulation of children outside of marriage and KHI is specifically for people who are Muslim. Therefore, the Constitutional Court Decision Number 46/PUU-VIII/2010 concerning the position of children out of wedlock is stipulated as a solution so that there is no legal dualism in society. The Constitutional Court's decision was determined when Aisyah Moechtar submitted a judicial review to the Constitution Court about constitutionality of Article 2 paragraph (2) and Article 43 paragraph (1) of Law no. 1 of 1974 concerning Marriage. This happens because of the legal meaning of the phrase "born out of wedlock," so that there are multiple interpretations of the position and legal this consequences. Research method is normative juridical research using statutory approach to then conducted in-depth analysis. With the issuance of the decision of the Constitutional Court, children out of wedlock have a civil relationship with their mother, their father and father's family if it can be proven by science and technology. It should be understood that the illegitimate child referred to in the decision is an illegitimate child resulting from a religiously legal marriage (siri marriage) but is not recorded in state documents and does not apply to illegitimate children resulting from adultery so that the clear legal consequences.
IMPLEMENTATION OF SANCTIONS AGAINST THE PERFORMERS OF THE GIAM BIOSPHERE DESTROYER IN SIAK DISTRICT
Authors: S. Dalimunthe Budiman
Published: June 2023

Based on Article 50 of Law Number 41 of 1999 concerning Forestry, it is regulated that everyone is prohibited from encroaching on forest areas and cutting down trees in forest areas. The enactment of Law Number 18 of 2013 concerning Prevention and Eradication of Forest Destruction has further strengthened the legal basis for forest protection in Indonesia. Based on Article 12 of Law Number 18 of 2013 concerning Prevention and Eradication of Forest Destruction, it is regulated that everyone is prohibited from cutting trees in forest areas. However, in 2017, the Riau Regional Police succeeded in uncovering a case of illegal logging that occurred inside the Giam Siak Kecil-Bukit Batu Biosphere Reserve in Siak Regency. The method used in this research is sociological law research. The application of sanctions against perpetrators of forest destruction of the Giam Biosphere in Siak Regency based on Law Number 41 of 1999 concerning Forestry and Law Number 18 of 2013 concerning Prevention and Eradication of Forest Destruction has not been optimal. The community cannot be blamed for forest encroachment and tree cutting inside the Giam Siak Kecil-Bukit Batu Biosphere Reserve in Siak Regency because the Giam Siak Kecil-Bukit Batu Biosphere Reserve before it became a state-protected biosphere reserve was where the community lived. The Giam Siak Kecil-Bukit Batu Biosphere Reserve in Siak Regency has been inhabited and managed by the community for generations to meet the needs of daily life. There are two efforts made to prevent the destruction of the Giam Siak Kecil-Bukit Batu Biosphere Reserve forest, namely preventive efforts and repressive efforts. In addition, the concept of implementing administrative sanctions as primum remedium and the principle of strict liability offered in Law Number 32 of 2009 concerning Environmental Protection and Management is part of sustainable development efforts.
IMPLEMENTATION OF COLLECTION OF NAD LOANS THROUGH AUCTION ON LIABILITY RIGHTS AS GUARANTEE IN PT. BPD SUMATERA BARAT
Authors: Khair Umul , Ramadhona Ana , Rosman Edi
Published: June 2023

Basically, the granting of credit facilities can be done by anyone, as long as the person concerned has the ability to do so, through a loan agreement between the lender (creditor on the one hand) and the loan recipient (debtor on the other). However, in practice, the debtor always agrees to the loan agreement by the creditor even though the interest is very high. In order to guarantee the interests of the bank, the debtor is required to provide a guarantee/collateral to the bank PT. BPD West Sumatra is one of the banks that implement auctions as a way of resolving non-performing loans. The Bank will submit an auction to be executed by the State Property and Auction Service Office (KPKNL). So the procedure for settling bad loans through auctions at PT. BPD West Sumatra for example at Bank Nagari Payakumbuh Branch has complied with other banking regulations guided by the Regulation of the Minister of Finance in particular Article 6 and Article 20, as well as Regulation of the Minister of Finance No. 106/PMK.06/2013 concerning Amendments to the Regulation of the Minister of Finance No. 93/PMK.06/2010 concerning Instructions for Implementation of Auctions, and the object of Collateral that can be processed for auction is collateral that has been installed with Mortgage through the Office of the State Assets and Auction Service (KPKNL).
LEGAL LIABILITY ON ADMINISTRATIVE TORT: RECENT REGULATION PERSPECTIVE
Authors: Sisma Muhammad Farizka , Adlhiyati Zakki
Published: June 2023

The development of judicial power brings some changes. One is the evolution of administrative law related to the object of administrative dispute, which embraces factual action. Thus, the administrative tort was also affected by this change. This writing aims to understand the government's liability on the administrative tort and the regulation of onrechtmatige overheidsdaad before and after the enactment of Law Number 30/2014 on government administration. The legal research method reveals that the government's liability on administrative tort is based on the origin of the authority (attribution, delegation, or mandate). Initially, the administrative tort done by the government was regulated by the article of 1365 Civil Law, but in 2014 it was also stipulated in the Government Administration Law. In addition, The Law of Government administration broadens the limitation of administrative decisions and makes the administrative court legally able to examine the administrative tort.
INSTALLATION OF ELECTRONIC DETECTION DEVICES ON PERSONS OF SEXUAL VIOLANCE AGAINST CHILDRENS (PROBLEMATICS AND SOLUTIONS)
Authors: Alifa Virgie Kesfian , Harefa Beniharmoni
Published: June 2023

Act No. 17 of 2016 pertaining to the PERPU No. 1 of 2016 pertaining to the second amendment to the Law No. 23 of 2002 on Child Protection is being considered as the number of cases of sexual violence against children increases annually. Therefore, it is necessary to increase the penalties for those who sexually assault children. Government Regulation 70 of 2020 regulates using electronic detection devices as a secondary penalty. However, since their enactment until now, there has been no judge's decision determining the other party's liability for the installation of this electronic detection device. This is due to the fact that the regulation itself contains numerous flawed instruments. This study aims to identify the problems and potential solutions associated with installing electronic detection devices on perpetrators of sexual violence against children. This research leads to an examination of normative legal law, with data gathered through document studies. PP 70/2020's rules for the application of the installation of electronic detectors contain a number of flaws with respect to a number of instruments, as revealed by the research results. This issue will then be compared to the regulations of several countries that have implemented it, such as the Netherlands, England, and the United States so that a solution can be found to apply penalties for the installation of electronic detection devices, specifically how to operate the device using GPS technology and the form of the tool in the form of an electronic bracelet attached to the leg of the perpetrator of sexual harassment against children.
A constelação sensível do imaginário das ambiências urbanas
Authors: La Rocca Fabio
Published: June 2023

O artigo traz uma reflexão sobre como pensar a cidade contemporânea e seus espaços: seus fragmentos significativos e sensíveis. Para tanto, investiga-se “como” a cidade é e se apresenta, e de que maneira posicionamos nosso olhar em uma estratégia de ontologia do presente. O “como” acompanha o pensamento e a observação em profundidade, trata-se de um situacionismo metodológico que se opõe ao pensamento a priori. Desde uma perspectiva da ontologia da atualidade, a análise nos permite dizer o que se experimenta no aqui e agora da existência. Enfim, o imaginário das ambiências urbanas pode ser tido como um efeito de percepção da cidade, que não pode ser separada do real, pois dela fazem parte efeitos, partes e atmosferas.
miR-9 utilizes precursor pathways in adaptation to alcohol in mouse striatal neurons
Authors: Mead Edward Andrew , Wang Yongping , Patel Sunali , Thekkumthala Austin P. , Kepich Rebecca , Benn-Hirsch Elizabeth , Lee Victoria , Basaly Azra , Bergeson Susan , Siegelmann Hava T. , Pietrzykowski Andrzej Zbigniew
Published: June 2023

microRNA-9 (miR-9) is one of the most abundant microRNAs in the mammalian brain, essential for its development and normal function. In neurons, it regulates the expression of several key molecules, ranging from ion channels to enzymes, to transcription factors broadly affecting the expression of many genes. The neuronal effects of alcohol, one of the most abused drugs in the world, seem to be at least partially dependent on regulating the expression of miR-9. We previously observed that molecular mechanisms of the development of alcohol tolerance are miR-9 dependent. Since a critical feature of alcohol action is temporal exposure to the drug, we decided to better understand the time dependence of alcohol regulation of miR-9 biogenesis and expression. We measured the effect of intoxicating concentration of alcohol (20 mM ethanol) on the expression of all major elements of miR-9 biogenesis: three pri-precursors (pri-mir-9-1, pri-mir-9-2, pri-mir-9-3), three pre-precursors (pre-mir-9-1, pre-mir-9-2, pre-mir-9-3), and two mature microRNAs: miR-9-5p and miR-9-3p, using digital PCR and RT-qPCR, and murine primary medium spiny neurons (MSN) cultures. We subjected the neurons to alcohol based on an exposure/withdrawal matrix of different exposure times (from 15 min to 24 h) followed by different withdrawal times (from 0 h to 24 h). We observed that a short exposure increased mature miR-9-5p expression, which was followed by a gradual decrease and subsequent increase of the expression, returning to pre-exposure levels within 24 h. Temporal changes of miR-9-3p expression were complementing miR-9-5p changes. Interestingly, an extended, continuous presence of the drug caused a similar pattern. These results suggest the presence of the adaptive mechanisms of miR-9 expression in the presence and absence of alcohol. Measurement of miR-9 pre- and pri-precursors showed further that the primary effect of alcohol on miR-9 is through the mir-9-2 precursor pathway with a smaller contribution of mir-9-1 and mir-9-3 precursors. Our results provide new insight into the adaptive mechanisms of neurons to alcohol exposure. It would be of interest to determine next which microRNA-based mechanisms are involved in a transition from the acute, intoxicating effects of alcohol to the chronic, addictive effects of the drug.
GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma
Authors: Klein Martin , Dijoux Eleonore , Cheminant Marie-Aude , Intes Laurent , Bouchaud Grégory
Published: June 2023

Background

Asthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen species (ROS), play a major role. Superoxide dismutases (SODs) are enzymes that constitute the first line of defense against ROS. Melon SOD-gliadin, which is known as GliSODin®, is commonly used as a nutritional supplement that has proven antioxidant properties.

Objectives

In this study, we evaluated the efficacy and mechanism of action GliSODin® in the treatment of allergic asthma.

Methods

House dust mite (HDM)-induced asthmatic mice were orally exposed to GliSODin®, and airway hyperresponsiveness, lung inflammation,in vitroT-cell polarization,in vivoT-cell reactivation, and blood immunoglobulin were investigated.

Results

GliSODin® reduced airway hyperresponsiveness, lung innate and adaptive immune response, and HDM-specific IgE production. Coculturing CD4+ T-cell with HDM-sensitized dendritic cells and GliSODin® reduced T-cell polarization into Th2 and Th17 cells. Moreover, adoptively transferred CD4+ T cells from asthmatic mice exhibited a reduced reactivation of Th2 and Th17 cells following stimulation with HDM plus GliSODin®.

Conclusion

GliSODin® abrogates asthma features and reduces CD4+ T-cell polarization and reactivation. Taken together, these data suggest that GliSODin® could be used for the management of asthma symptoms.
Case report: Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2
Authors: Su Ying , Ran Chun-Qiong , Liu Zhe-Long , Yang Yan , Yuan Gang , Hu Shu-Hong , Yu Xue-Feng , He Wen-Tao
Published: June 2023

Background: Stickler syndrome (SS) is a group of hereditary collagenopathies caused by a variety of collagen and non-collagen genes. Affected patients have characteristic manifestations involving ophthalmic, articular, craniofacial and auditory disorders. SS is classified into several subtypes according to clinical and molecular features. Type 3 SS is an ultra-rare disease, known as non-ocular SS or otospondylomegaepiphyseal dysplasia (OSMED) with only a few pathogenic COL11A2 variants reported to date.

Case presentation: A 29-year-old Chinese male was referred to our hospital for hearing loss and multiple joint pain. He presented a phenotype highly suggestive of OSMED, including progressive sensorineural deafness, spondyloepiphyseal dysplasia with large epiphyses, platyspondyly, degenerative osteoarthritis, and sunken nasal bridge. We detected compound heterozygous mutations in COL11A2, both of which were predicted to be splicing mutations. One is synonymous mutation c.3774C>T (p.Gly1258Gly) supposed to be a splice site mutation, the other is a novel intron mutation c.4750 + 5 G>A, which is a highly conservative site across several species. We also present a review of the current known pathogenic mutation spectrum of COL11A2 in patients with type 3 SS.

Conclusion: Both synonymous extonic and intronic variants are easily overlooked by whole-exome sequencing. For patients with clinical manifestations suspected of SS syndrome, next-generation whole-genome sequencing is necessary for precision diagnosis and genetic counseling.
Regulation of T cell differentiation and function by long noncoding RNAs in homeostasis and cancer
Authors: Erber Julia , Herndler-Brandstetter Dietmar
Published: June 2023

Long noncoding RNAs (lncRNAs) increase in genomes of complex organisms and represent the largest group of RNA genes transcribed in mammalian cells. Previously considered only transcriptional noise, lncRNAs comprise a heterogeneous class of transcripts that are emerging as critical regulators of T cell-mediated immunity. Here we summarize the lncRNA expression landscape of different T cell subsets and highlight recent advances in the role of lncRNAs in regulating T cell differentiation, function and exhaustion during homeostasis and cancer. We discuss the different molecular mechanisms of lncRNAs and highlight lncRNAs that can serve as novel targets to modulate T cell function or to improve the response to cancer immunotherapies by modulating the immunosuppressive tumor microenvironment.
Monitoring immunomodulation strategies in type 1 diabetes
Authors: Krishnamurthy Balasubramanian , Lacorcia Matthew , Kay Thomas W. H. , Thomas Helen E. , Mannering Stuart I.
Published: June 2023

Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease. Short-term treatment with agents targeting T cells, B cells and inflammatory cytokines to modify the disease course resulted in a short-term pause in disease activity. Lessons learnt from these trials will be discussed in this review. It is expected that effective disease-modifying agents will become available for use in earlier stages of T1D. Progress has been made to analyze antigen-specific T cells with standardization of T cell assay and discovery of antigen epitopes but there are many challenges. High-dimensional profiling of gene, protein and TCR expression at single cell level with innovative computational tools should lead to novel biomarker discovery. With this, assays to detect, quantify and characterize the phenotype and function of antigen-specific T cells will continuously evolve. An improved understanding of T cell responses will help researchers and clinicians to better predict disease onset, and progression, and the therapeutic efficacy of interventions to prevent or arrest T1D.
Cost-effectiveness of therapeutic infant formulas for cow's milk protein allergy management
Authors: Suratannon Narissara , Prapansilp Panote , Srinarongsook Athitaya , Tanpowpong Pornthep , Chatchatee Pantipa , Pongpirul Krit
Published: June 2023

Cow's milk protein allergy (CMPA) is children's most common food allergy. Therapeutic infant formulas for CMPA lead to symptom-free and potentially benefit early tolerance induction and reducing the allergic march in non-breastfed babies. This study assessed the cost-effectiveness of CMPA management with different therapeutic infant formulas in Thailand, which may reflect situations in developing countries throughout Asia. An analytic decision model was developed to simulate the occurrence of eczema, urticaria, asthma, rhinoconjunctivitis, or being symptom-free in infants with CMPA over 36 months. Extensively hydrolyzed casein formula with added probiotic Lacticaseibacillus rhamnosus (previously Lactobacillus rhamnosus) strain GG (EHCF+LGG), extensively hydrolyzed whey formula (EHWF), soy protein-based formula (SPF), and amino acid formula (AAF) were compared from the healthcare payer perspective. The results from a prospective cohort study were used for comparative effectiveness measures, while local experts were interviewed to estimate the healthcare resource used in the management of CMPA. The costs of healthcare resources were obtained from standard, publicly available sources. The direct medical cost of CMPA management was lowest for EHCF+LGG (USD 1,720), followed by SPF (USD 2,090), EHWF (USD 2,791), and AAF (USD 7,881). Compared with other formulas, EHCF+LGG was expected to save USD 370 (SPF), USD 1,071 (EHWF), and USD 6,161 (AAF) in the total cost of CMPA management over 36 months. In conclusion, EHCF+LGG was the most cost-effective strategy for managing non-breastfed infants with CMPA. This strategy was associated with more children developing immune tolerance to cow's milk and being symptom-free, contributing to overall cost-saving potential.
Transarterial chemoembolization for advanced hepatocellular carcinoma without macrovascular invasion or extrahepatic metastasis: analysis of factors prognostic of clinical outcomes
Authors: Kim Ji Hoon , Kim Jin Hyoung , Yoon Hyun-Ki , Ko Gi-Young , Shin Ji Hoon , Gwon Dong Il , Ko Heung-Kyu , Chu Hee Ho , Kim Seong Ho , Kim Gun Ha , Kim Yonghun , Aljerdah Shakir
Published: June 2023

Objectives

To evaluate the safety and efficacy of TACE and factors predicting survival in patients with advanced hepatocellular carcinoma (HCC) without macrovascular invasion (MVI) or extrahepatic spread (EHS).

Methods

This single-center retrospective study included 236 treatment-naïve patients who underwent TACE as first-line treatment for advanced HCC without MVI or EHS between January 2007 and December 2021.

Results

Following TACE, the median overall survival (OS) was 24 months. Multivariate Cox regression analyses revealed that tumor number ≥4 (risk point: 3), maximal tumor size >10 cm (risk point: 2), Child–Pugh class B (risk point: 2), alpha-fetoprotein (AFP) concentration ≥400 ng/mL (risk point: 2), and presence of HCC rupture (risk point: 2) were risk factors significantly associated with OS. The expected median OS among patients with <2, 2–4, and 5–9 risk points were 72, 29, and 12 months respectively. The major complication rates were significantly lower in patients with maximal tumor size ≤10 cm than in those with maximal tumor size >10 cm (4% [5/138] vs 21% [21/98], p = 0.001).

Conclusion

TACE may be safe and effective in selected patients with advanced HCC without MVI or EHS, with a median OS of 24 months. Patients with limited tumor burden, compensated liver function, absence of HCC rupture, and favorable biologic markers may benefit the most from TACE. TACE is not recommended for patients with huge HCCs (>10 cm) because of its high rate of major complications (21%).
Differential contributions of two domains of NAI2 to the formation of the endoplasmic reticulum body
Authors: Choi Yun Ju , Geem Kyoung Rok , Kim Jitae , Lee Dong Wook
Published: June 2023

The endoplasmic reticulum (ER) serves essential functions in eukaryotic cells, including protein folding, transport of secretory proteins, and lipid synthesis. The ER is a highly dynamic organelle that generates various types of compartments. Among them, the ER body is specifically present in plants in the Brassicaceae family and plays a crucial role in chemical defense against pathogens. The NAI2 protein is essential for ER body formation, and its ectopic overexpression is sufficient to induce ER body formation even in the leaves of Nicotiana benthamiana, where the ER body does not naturally exist. Despite the significance of NAI2 in ER body formation, the mechanism whereby NAI2 mediates ER body formation is not fully clear. This study aimed to investigate how two domains of Arabidopsis NAI2, the Glu-Phe-Glu (EFE) domain (ED) and the NAI2 domain (ND), contribute to ER body formation in N. benthamiana leaves. Using co-immunoprecipitation and bimolecular fluorescence complementation assays, we found that the ND is critical for homomeric interaction of NAI2 and ER body formation. Moreover, deletion of ED induced the formation of enlarged ER bodies, suggesting that ED plays a regulatory role during ER body formation. Our results indicate that the two domains of NAI2 cooperate to induce ER body formation in a balanced manner.
Phylogenomics and plastome evolution of Indigofera (Fabaceae)
Authors: Zhou Sheng-Mao , Wang Fang , Yan Si-Yuan , Zhu Zhang-Ming , Gao Xin-Fen , Zhao Xue-Li
Published: June 2023

Introduction

Indigofera L. is the third largest genus in Fabaceae and includes economically important species that are used for indigo dye-producing, medicinal, ornamental, and soil and water conservation. The genus is taxonomically difficult due to the high level of overlap in morphological characters of interspecies, fewer reliability states for classification, and extensive adaptive evolution. Previous characteristic-based taxonomy and nuclear ITS-based phylogenies have contributed to our understanding of Indigofera taxonomy and evolution. However, the lack of chloroplast genomic resources limits our comprehensive understanding of the phylogenetic relationships and evolutionary processes of Indigofera.

Methods

Here, we newly assembled 18 chloroplast genomes of Indigofera. We performed a series of analyses of genome structure, nucleotide diversity, phylogenetic analysis, species pairwise Ka/Ks ratios, and positive selection analysis by combining with allied species in Papilionoideae.

Results and discussion

The chloroplast genomes of Indigofera exhibited highly conserved structures and ranged in size from 157,918 to 160,040 bp, containing 83 protein-coding genes, 37 tRNA genes, and eight rRNA genes. Thirteen highly variable regions were identified, of which trnK-rbcL, ndhF-trnL, and ycf1 were considered as candidate DNA barcodes for species identification of Indigofera. Phylogenetic analysis using maximum likelihood (ML) and Bayesian inference (BI) methods based on complete chloroplast genome and protein-coding genes (PCGs) generated a well-resolved phylogeny of Indigofera and allied species. Indigofera monophyly was strongly supported, and four monophyletic lineages (i.e., the Pantropical, East Asian, Tethyan, and Palaeotropical clades) were resolved within the genus. The species pairwise Ka/Ks ratios showed values lower than 1, and 13 genes with significant posterior probabilities for codon sites were identified in the positive selection analysis using the branch-site model, eight of which were associated with photosynthesis. Positive selection of accD suggested that Indigofera species have experienced adaptive evolution to selection pressures imposed by their herbivores and pathogens. Our study provided insight into the structural variation of chloroplast genomes, phylogenetic relationships, and adaptive evolution in Indigofera. These results will facilitate future studies on species identification, interspecific and intraspecific delimitation, adaptive evolution, and the phylogenetic relationships of the genus Indigofera.