bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase Contrast MR as Non-Invasive Tool in the Diagnosis of Benign Intracranial Hypertension
Authors: Nocetti L. , Mantovani A. , Vallone S. , Costi T. , Carpeggiani P. , Pinna G.
Published: April 2015

Idiopathic intracranial hypertension (IIH) is characterized by an increased intracranial pressure in the absence of expansive lesions or cerebrospinal fluid (CSF) circulation obstructions. Its physiopathology is still not fully understood. The diagnosis is currently established on clinical grounds (Dandy criteria) along with an invasive measurement of CSF dynamic parameters through the infusion test. This study compares the invasive pressure measurements with the biomechanical CSF parameters derived from a phase-contrast MR protocol to evaluate the accuracy and reliability of the phase-contrast MR protocol.
How to Distinguish between Venous and Arterial Strokes and Why?
Authors: Semenov S. , Moldavskaya I. , Shatokhina M. , Semenov A. , Barbarash L.
Published: April 2015

Cerebral venous infarct is considered to be rare (0–5% of all strokes). In some cases venous infarcts with no specific signs on conventional CT or MR study are not diagnosed due to incomplete examination. A venous infarct more often (63%) than an arterial (15%) infarct is accompanied by hemorrhage (primary or secondary in the early period) and a high risk of hemorrhage should be a contraindication to intravenous thrombolysis. Consequently, the definition of the kind of a stroke should lead to different therapeutic tactics. Using MR and CT angiographic and perfusion techniques in the urgent examination of patients with an infarct, considering time necessary for the “time window”, can lead to exact diagnosis and fewer complications.
Tuberculosis Simulating Brain Tumour
Authors: Chaudhry U.R. , Farooq M. , Rauf F. , Bhatti S.K.
Published: April 2015

The purpose of the study is to highlight the varied presentation of tuberculosis (TB) simulating a brain tumour. Headache and seizures are becoming frequent presenting complaints without any history of tuberculosis. The study comprises 1200 patients of both sexes with ages ranging from ten to sixty years. CT scan and MRI brain control with and without contrast medium were the investigations performed in these cases. In some patients Electroencephalography (EEG), cerebral angiography (DSA) and spectroscopy were also performed. The final diagnosis of tuberculosis was made on the basis of craniotomy, stereotactic and burr hole biopsies with histopathology in most of the cases. Forty per cent of the patients were followed up for eight months. They were put on anti-tuberculosis treatment with symptomatic and anti-epileptic drugs. The incidence was 544 and 757 per 100,000 in Africa and Indo Pakistan respectively. The male to female ratio was 1:1. Tuberculosis, especially with CNS involvement, is not only common in immunosuppressed patients in our setting, but TB has been and remains an important public health problem. TB may involve the CNS either as meningitis or as parenchymal granulomas or abscesses. Patients with brain TB usually present with fever, multiple cranial nerve involvement and occasional behavioural changes. CSF findings remain non specific in most cases. The most common sites are the cerebral hemisphere and basal ganglion in adults and the cerebellum in children. Tuberculosis has unique findings on brain CT and MRI. Cortical and subcortical locations are typical whereas the brain stem is a less common site. Tuberculosis lesions are usually solitary but multiple in 10% to 35% of cases. In spite of all these facts some cases of brain TB still need aggressive neurointervention to reach the final diagnosis of brain TB. Tuberculosis in the CNS may manifest in many different ways. So one should always include tuberculosis in the differential diagnosis in the etiology of delayed onset epilepsy and acute on chronic headache. In case of a discrepancy between clinical manifestations and CT/MRI findings, one can always anticipate tuberculous lesion in the brain.
Dual-Acquisition Extracranial Computed Tomographic Angiography-Enhanced Neck Computed Tomography before Transoral Laser Microsurgery in Head and Neck Cancer Patients
Authors: Weindling S.M. , Salassa J.R. , Casler J.D. , Chellini D.L.
Published: April 2015

Transoral laser microsurgery (TLM) is an alternative surgical technique for piecemeal endoscopic resection of mucosal-based aerodigestive tract tumors. Though uncommon, potentially catastrophic postoperative bleeding may occur with this technique secondary to vascular injury along invasive tumor inner margins. We describe our preliminary results using a preoperative dual-acquisition extracranial computed tomographic angiography (CTA)-enhanced neck computed tomographic (CT) imaging and postprocessing protocol developed to improve visualization of mucosal-based head and neck tumors and adjacent arterial branches with the objective of facilitating TLM surgery and reducing secondary bleeding complications. Twenty patients with known head and neck cancers anticipated for TLM resection were selected for a dual-acquisition CTA-CT scanning and postprocessing protocol. The mucosal-based pharyngeal tumors and peritumoral vessel enhancement were compared on matched CTA and enhanced neck CT axial images. Operative reports and clinical notes were retrospectively reviewed to identify patients in whom the TLM surgical approach was altered or changed to conventional open surgery as a result of presurgical CTA-CT findings. Enhancement of peritumoral vasculature was almost uniformly superior (19 of 20 patients) on extracranial CTA compared with enhanced neck CT images. In six candidates for TLM surgery (30%), CTA findings resulted in a change in surgical approach to improve intraoperative peritumoral vascular control. In this small pilot series, primary tumor-peritumoral vessel relationships delineated by the addition of extracranial CTA to preoperative enhanced neck CT frequently impacted the surgical approach and facilitated TLM planning.
Neurocysticercosis Mimicking Brain Tumor
Authors: Vasiljević-VučKović V. , Medenica S. MilošEvić , Grujičić D.
Published: April 2015

Neurocysticercosis together with brain tumors is one of the leading causes of seizures in the developing world. In Western Europe NCC is rare and a high degree of physician awareness is necessary for diagnosis.
Clinico-Radiologic Profile of Spinal Cord Multiple Sclerosis in Adults
Authors: Bag A.K. , Patel B.N. , Osman S. , Roberson G.H.
Published: April 2015

MRI is extremely useful for the assessment of initial disease burden and to identify the dissemination of the multiple sclerosis (MS) in time and space. Though MRI of the spinal cord is not used to establish the diagnosis of MS, spinal cord is frequently involved in this disease and there has been increasing emphasis of the spinal imaging in making clinical decision in the management of MS. We undertook a retrospective study of patients with diagnosed MS: 1) to identify radiologic pattern of spinal cord involvement in MS and 2) to correlate radiologic findings with clinical presentation. We reviewed radiologic records from 2004 to 2009 of patients with abnormal T2 signal intensity of the spinal cord with radiologic concern of demyelinating disease. Patients in this cohort who met the Revised McDonald MS Diagnostic Criteria were included in this study. 166 patients were included in the study. There was preference for cervical spinal cord particularly posterior aspect of the spinal cord. Enhancement of the lesions was rare (4.1%). Mean lesion length was 18.2 mm. The average number of lesions per patient was 2.04. Sensory symptoms were predominating and most of the patients had relapsing-remitting course. Patients with sensory symptoms, bladder and bowel involvement and motor symptoms had almost equally distributed lesions among anterior, posterior and central spinal cord. However, all of the patients presented with posterior column signs and gait abnormality had involvement of the posterior spinal cord. Radiologic manifestation of spinal cord MS is extremely variable and can involve the entire length of the spinal cord. Clinical symptoms may or may not be associated with radiologic presentation of the lesions.
Axial Loaded Imaging of the Lumbar Spine 18 Years Later. Is it Still a Valuable Examination?
Authors: Cartolari R.
Published: April 2015

This paper reviews experience with 12100 Axial Loader (AL) studies of the lumbar spine both in CT and in MRI 18 years after the development of axial loaded CT and MRI. The Axial Loader device is described together with the CT and MR acquisitions. Disc, intersomatic and articular facet changes are described with a breakdown of the classification of abnormalities as elementary or complex dynamic modifications.
Spinal Arachnoid Cyst as an Infrequent Cause of Spinal Cord Compression
Authors: Gómez E. , Quiles A.M. , Pedraza S.
Published: April 2015

Spinal arachnoid cysts are rare lesions that may produce symptoms by compressing the spinal cord or nerve roots. MRI is essential for diagnosing this entity. We retrospectively reviewed the medical charts, radiological examinations, and follow-up data of four adults with spinal arachnoid cysts diagnosed in our center over a two-year period (2007-2009). All cysts were located in the thoracic spine. Three were dorsolateral to the spinal cord and one was ventral. Most had multiple septa but one had a single septum. Cyst size varied greatly; one cyst extended through eight vertebral bodies. One patient treated expectantly died of cardiovascular problems one year after the cyst was diagnosed. The other three patients underwent laminectomy and cyst fenestration; two had clinical and imaging signs of relapse after surgery. One of the patients with a relapsed cyst worsened clinically, developing syringomyelia and requiring reintervention with shunting to the subarachnoid space. The outcome of the operation was good in the case of the single septum. Spinal arachnoid cyst is uncommon. Its diagnosis is complex because the symptoms are unspecific and the imaging findings are subtle. Spinal arachnoid cyst should be included in the differential diagnosis of chronic paraparesis. Imaging plays an essential role in the diagnosis, follow-up and management of spinal arachnoid cysts.
Imaging Artifacts in MRI Simulators
Authors: Carrasco S. , Huete I. , Zunino R.
Published: April 2015

Artifactual images are created in the process of imaging. They are images that distort reality, i.e. they do not correspond to the image but they arise from them and are false. This paper describes image artifacts in MR that can lead to misdiagnosis, analyzes their causes and reviews the most common imaging artifacts.
mild® Lumbar Decompression for the Treatment of Lumbar Spinal Stenosis
Authors: Schomer D.F. , Solsberg D. , Wong W. , Chopko B.W.
Published: April 2015

More than 1.2 million people are undergoing treatment for lumbar spinal stenosis (LSS) in the United States. Yet, therapeutic options for these patients are limited to either conservative treatments or highly invasive surgeries. A new image-guided interlaminar decompression procedure, mild®, offers significant relief for many of these patients by debulking dorsal element hypertrophy while preserving structural stability. mild can be performed without general anesthesia and offers a short recovery period. A meta-analysis of four clinical patient series from multiple institutions in the United States evaluated over 250 patients for safety and clinical efficacy of the mild procedure. Clinical efficacy was evaluated at baseline and at three-month follow-up using validated patient reported outcomes (PRO) instruments including the ten-point Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI). Acute safety and patient outcomes was compared to the Spine Patient Outcomes Research Trial (SPORT). No device or procedure-related serious adverse events (SAEs) have been recorded with the mild procedure. Outcome metrics for patients treated with mild demonstrated statistically significant symptomatic improvement over baseline. When compared to open surgery, mild efficacy results compare favorably, and complication rates are much lower. mild is a safe and effective procedure that decompresses LSS in a minimally invasive manner while preserving the structural stability of the spine.
Percutaneous Treatment of Lumbar Intervertebral Disc Hernias with Discogel
Authors: Pardatscher K. , Volpentesta G. , Bombardieri C. , Giaquinta A.
Published: April 2015

A new percutaneous technique for the treatment of the backache and sciatica related to the lumbar disc herniation was applied in 34 patients at 40 levels. The technique is easy, safe, efficacious and without complications. In particular it is useful for the diagnosis and treatment of the underestimated “internal disc disruption” syndrome.
Classification of Non-Aneurysmal Subarachnoid Haemorrhage: CT Correlation to the Clinical Outcome
Authors: Nayak S. , Kunz A.B. , Kieslinger K. , Ladurner G. , Killer M.
Published: April 2015

To propose a new computed tomography (CT)-based classification system for nonaneurysmal subarachnoid haemorrhage (SAH), which predicts patients' discharge clinical outcome and helps to prioritize appropriate patient management. A 5-year, retrospective, two-centre study was carried out involving 1486 patients presenting with SAH. One hundred and ninety patients with nonaneurysmal SAH were included in the study. Initial cranial CT findings at admission were correlated with the patients' discharge outcomes measured using the Modified Rankin Scale (MRS). A CT-based classification system (type 1 e 4) was devised based on the topography of the initial haemorrhage pattern. Seventy-five percent of the patients had type 1 haemorrhage and all these patients had a good clinical outcome with a discharge MRS of 1. Eight percent of the patients presented with type 2 haemorrhage, 62% of which were discharged with MRS of 1 and 12% of patients had MRS 3 or 4. Type 3 haemorrhage was found in 10%, of which 16% had good clinical outcome, but 53% had moderate to severe disability (MRS 3 and 4) and 5% were discharged with severe disability (MRS 5). Six percent of patients presented with type 4 haemorrhage of which 42% of the patients had moderate to severe disability (MRS 3 and 4), 42% had severe disability and one-sixth of the patients died. Highly significant differences were found between type 1 (1a and 1b) and type 2 (p 1/4 0.003); type 2 and type 3 (p 1/4 0.002); type 3 and type 4 (p 1/4 0.001). Haemorrhages of the type 1 category are usually benign and do not warrant an extensive battery of clinical and radiological investigations. Type 2 haemorrhages have a varying prognosis and need to be investigated and managed along similar lines as that of an aneurysmal haemorrhage with emphasis towards radiological investigation. Type 3 and type 4 haemorrhages need to be extensively investigated to find an underlying cause.
Endovascular Treatment of Distal Cerebral Aneurysms
Authors: Prstojevic B. , Samardzic M. , Vukasinovic I.
Published: April 2015

Distal cerebral aneurysms are difficult to treat. Endovascular treatment (EVT) although challenging, in many cases allows sparing of the parent artery. If a deconstructive approach is necessary, EVT enables hyperselective catheterization with sacrificing only the branch on which aneurysm is located. Consequently much of the surrounding arterial circulation is spared. We describe our series of endovascularly treated distal cerebral aneurysms in 2009. This is a retrospective review of seven consecutive patients (five women) with eight distal cerebral aneurysms (four ruptured) who underwent embolization in 2009. Patient ages ranged from 44 to 69 years. Aneurysm size distribution was: seven small (0-10 mm) and one large (11-24 mm). Two aneurysms required a deconstructive approach. Embolization was performed with coils in six cases, and with liquid embolic material Onyx in two cases. Endovascular treatment was successful in all cases. Immediate angiograms revealed complete occlusion in six aneurysms, none with neck remnants, and incomplete occlusion in two aneurysms. On first follow-up (3-6 month) obtained in six patients, five aneurysms showed stabile occlusion, and one recanalization due to coil impaction. None of the patients died. One patient had neurological deficit GOS (Glasgow Outcome Scale) score three caused by parent artery occlusion, which gradually improved to GOS score 4. EVT is safe and effective technique for distal cerebral aneurysms.
Intracranial Perianeurysmal Cyst: Still a Dilemma
Authors: Galdamez M. Martinez , Lorente P. Saura , Rico A. Palomera , Pérez-Higueras A.
Published: April 2015

Intracranial perianeurysmal cysts constitute an extremely rare entity with very few cases reported in the literature. These cysts present an unknown mechanism of formation and clinical significance. Several theories based on isolated cases have been proposed, without drawing a clear conclusion. It is also unknown if follow-up with imaging techniques is required or which is the most appropriate treatment. We describe an atypical case handled with a satisfactory outcome after endovascular treatment, suggesting the importance of hydrodynamic forces as the key factors in the mechanism of formation. We believe that this case can help in future analysis of this rare entity.
Eosinophilic Granuloma Presenting as Post-Traumatic Scalp Hematoma with Epidural Hemorrhage
Authors: Pawar R.V. , Hagiwara M. , Milla S. , Wisoff J. , George A.E.
Published: April 2015

Langerhans cell histiocytosis (LCH) encompasses a range of clinical presentations. Pure osseous involvement is referred to as eosinophilic granuloma (EG), whereas systemic involvement can either be classified as Hand-Schuller-Christian disease or Letterer-Siwe syndrome. It is estimated that of the total incidence of LCH (0.5 per 100,000 children per year in the United States), nearly 70% are categorized as EG 1. We describe a case of clinically occult calvarial eosinophilic granuloma brought to medical attention only after a traumatic event led to scalp and epidural hemorrhage at the site of the lesion. Osseous EG initially presents as a painful or tender mass, at times even mimicking osteomyelitis. Computed tomography (CT) reveals a lytic lesion with beveled edges. Magnetic resonance (MR) imaging is often non-specific, but usually demonstrates a marrow-replacing process that is T1 hypointense, T2 hyperintense, with homogenous enhancement. The complex MR imaging findings in our case provided a unique perspective regarding the presentation of EG. Once pathology established eosinophilic granuloma, skeletal survey confirmed the lesion was solitary, despite a compelling history of present illness.
Evaluation of Spinal Vascular Malformations Using 64-Slice CT-Angiography
Authors: Medenica S. MilošEvić , Prstojević B. , VučKović V.
Published: April 2015

Spinal vascular malformations are rare but they pose a great risk of disability for patients. Although spinal DSA is the gold standard in the diagnostic evaluation of these vascular anomalies, it is an invasive, technically complicated and time-consuming method. The purpose of this report is to add to the knowledge of CT angiography as a non-invasive method that may become an alternative diagnostic tool in the imaging of spinal vascular anomalies.
Atypical Presentation of Coarctation of Aorta Mimicking a Spinal Vascular Malformation
Authors: Yalavarthy A. , Chandrasekhar A. , Rajeswaran R. , Raja A.
Published: April 2015

Coarctation of the aorta accounts for about 8% of all congenital heart diseases. It usually presents in infancy or later in the third decade depending on its severity. It has a wide spectrum varying from an asymptomatic presentation to cardiac and extracardiac manifestations with neurological complications. Coarctation presenting as a spinal complication is extremely rare. We describe a case of coarctation detected on magnetic resonance imaging (MRI) in a 40-year-old man with an uncommon presentation mimicking a spinal arteriovenous malformation (AVM). To our knowledge, coarctation presenting with a spinal manifestation, resembling an AVM is rare, and has not been reported to date.
A Case of Primitive Trigeminal Artery-Cavernous Fistula: Embolization, Complications and Strategy
Authors: Qingle Z. , Yong C. , Xiaofeng H. , Yanhao L.
Published: April 2015

A 22-year-old man with primitive trigeminal artery-cavernous fistula was admitted to our hospital. Embolization with Guglielmi detachable coils and microcoils was attempted on the fistula from the internal carotid artery. The last microcoil was incorrectly released to the basilar artery through the primitive trigeminal artery. The misplaced microcoil was eventually retrieved by goose-neck snare. There was no related complication in the follow-up period.
1H MR Spectroscopy of Meningiomas at 3.0T: The Role of Glutamate-Glutamine Complex and Glutathione
Authors: Crisi G.
Published: April 2015

Proton magnetic resonance spectroscopy (1H MRS) has been used extensively for the characterization of the intracranial meningiomas. A major emphasis is placed on identification of an alanine (Ala) content within these tumors. Less attention is given to other metabolites such as glutamine and glutamate (Glx). Our objective was to assess the incidence and the relevance of the Glx content in meningiomas, to evaluate their usefulness versus Ala in the diagnosis of intracranial meningiomas and to indicate a potential role of other biochemical compounds such as glutathione (GSH). We performed a retrospective review of the 1H MRS spectra at 3.0T of 16 intracranial meningiomas in 16 consecutive patients with newly diagnosed tumors. All meningiomas were evaluated with single- voxel 1H MRS at short echo time using an automatic quantitation of the metabolites by linear combination model (LCModel) fitting. Detailed analysis of the spectra showed that the Glx content was a more common result (100%) than the Ala content (44%). The Glx content can be considered in high concentrations within these tumors resulting in overall levels comparable to normal brain values (P > 0.2). A glutathione (GSH) spectrum was added to the LCModel basis set in six meningiomas and in all of them a GSH peak was detected at 2.95 ppm (100%). Other metabolites such as guanidinoacetate (Gua) were detected in six meningiomas (38%) and this was not reported previously. Our data indicate that Glx and GSH are far more likely to be biochemical predictors than Ala in the 1H MRS evaluation of intracranial meningiomas. The significance of Gua as another potential marker of the meningioma cell metabolism needs to be further investigated.
Abnormal Cholesterol is Associated with Prefrontal White Matter Abnormalities among Obese Adults: A Diffusion Tensor Imaging Study
Authors: Cohen J.I. , Cazettes F. , Convit A.
Published: April 2015

The brain is the most cholesterol-rich organ in the body. Although most of the cholesterol in the brain is produced endogenously, some studies suggest that systemic cholesterol may be able to enter the brain. We investigated whether abnormal cholesterol profiles correlated with diffusion-tensor-imaging-based estimates of white matter microstructural integrity of lean and overweight/obese (o/o) adults. Twenty-two lean and 39 obese adults underwent magnetic resonance imaging, kept a three-day food diary, and had a standardized assessment of fasting blood lipids. The lean group ate less cholesterol-rich food than o/o although both groups ate equivalent servings of food per day. Voxelwise correlational analyses controlling for age, diabetes, and white matter hyperintensities, resulted in two significant clusters of negative associations between abnormal cholesterol profile and fractional anisotropy, located in the left and right prefrontal lobes. When the groups were split, the lean subjects showed no associations, whereas the o/o group expanded the association to three significant clusters, still in the frontal lobes. These findings suggest that cholesterol profile abnormalities may explain some of the reductions in white matter microstructural integrity that are reported in obesity.
An Orbital Lymphoma Involving the Pterygopalatine and Infratemporal Fossae
Authors: Conte G. , D'Amore A. , Viglianesi A. , Chiaramonte R. , Puzzo L. , Caltabiano R. , Lanzafame S. , Pero G. , Chiaramonte I.
Published: April 2015

Lymphoma is the most common malignant orbital tumor. We describe the imaging features of diffuse orbital follicular lymphoma with extension into the pterygopalatine fossa and infratemporal fossa without bony infiltration.
Prediction of Conversion from Mild Cognitive Impairment to Alzheimer Disease Based on Bayesian Data Mining with Ensemble Learning
Authors: Chen R. , Young K. , Chao L.L. , Miller B. , Yaffe K. , Weiner M.W. , Herskovits E.H.
Published: April 2015

Prediction of disease progress is of great importance to Alzheimer disease (AD) researchers and clinicians. Previous attempts at constructing predictive models have been hindered by undersampling, and restriction to linear associations among variables, among other problems. To address these problems, we propose a novel Bayesian data-mining method called Bayesian Outcome Prediction with Ensemble Learning (BOPEL). BOPEL uses a Bayesian-network representation with boosting, to allow the detection of nonlinear multivariate associations, and incorporates resampling-based feature selection to prevent over-fitting caused by undersampling. We demonstrate the use of this approach in predicting conversion to AD in individuals with mild cognitive impairment (MCI), based on structural magnetic-resonance and magnetic-resonance–spectroscopy data. This study includes 26 subjects with amnestic MCI: the converter group (n = 8) met MCI criteria at baseline, but converted to AD within five years, whereas the non-converter group (n = 18) met MCI criteria at baseline and at follow-up. We found that BOPEL accurately differentiates MCI converters from non-converters, based on the baseline volumes of the left hippocampus, the banks of the right superior temporal sulcus, the right entorhinal cortex, the left lingual gyrus, and the rostral aspect of the left middle frontal gyrus. Prediction accuracy was 0.81, sensitivity was 0.63 and specificity was 0.89. We validated the generated predictive model with an independent data set constructed from the Alzheimer Disease Neuroimaging Initiative database, and again found high predictive accuracy (0.75).
Early Diffusion-Weighted Imaging Findings in Hypoxic-Anoxic Injury
Authors: Von Fischer N. , Eng H. Yee , Vagal A.
Published: April 2015

Anoxic brain injury can lead to death or permanent neurological defects involving memory, personality, vision, and language. It is well established that magnetic resonance imaging (MRI), specifically diffusion-weighted imaging (DWI), allows for earlier and more accurate diagnosis than computed tomography for this type of insult. Here we describe three cases of diffuse cerebral anoxia in which conventional MRI in the early subacute phase demonstrated near normal findings and abnormalities were most evident on DWI and apparent diffusion coefficient maps. The cases presented are unique and instructive as these abnormalities could be mistakenly interpreted as normal due to their uniform and symmetric appearance.
Cerebral Thromboembolism: Value of Susceptibility-Weighted Imaging in the Initial Diagnosis of Acute Infarction
Authors: Mamlouk M.D. , Tsai F.Y. , Drachman D. , Stradling D. , Hasso A.N.
Published: April 2015

Susceptibility-weighted imaging (SWI) is commonly used to diagnose cerebral hemorrhage, calcification, and other T2* lesions. Its role in the detection of cerebral thromboemboli has been suggested for emboli of the anterior division of the middle cerebral artery (MCA). The purpose of our study was to determine SWI's accuracy and sensitivity in detection of all sites of cerebral thromboemboli, not just MCA emboli. Two neuroradiologists retrospectively reviewed consecutive MRI brain examinations with SWI for cerebral thromboemboli in 100 patients with clinical suspicion for stroke determined by the NIH Stroke Scale (NIHSS) score. FLAIR, MRA, CT, and catheter angiography were reviewed for thromboemboli in the same patients. Thromboembolic sites included: the internal carotid artery (ICA) terminus, anterior MCA, posterior MCA, any other cerebral artery, or if not present. The exclusion criteria included: no magnetic resonance angiogram (MRA) or catheter angiogram for comparison, lack of restricted diffusion, lacunar infarcts, and the presence of massive hemorrhage. The accuracy, sensitivity, and specificity of each imaging modality were determined. Twenty-four patients were excluded based on the aforementioned criteria. Cerebral thromboemboli were identified in 35 of the remaining 76 patients. Of the 35 patients with thromboemboli, 30 were identified on SWI. FLAIR detected 22/35 emboli, MRA 30/33, CT 18/35, and catheter angiography 12/12. The accuracies for SWI, FLAIR, and CT were 97%, 84%, and 74%, respectively. The sensitivities for SWI, FLAIR, and CT were 85%, 61%, and 52%, respectively. The specificities for SWI, FLAIR, and CT were 100%, 98%, and 93%, respectively. There is an adjunctive role of SWI to identify cerebral thromboemboli in patients with acute infarction. SWI is superior to FLAIR and CT, and complementary to MRA and catheter angiography in emboli detection. This study supports SWI detection of MCA emboli, but also emphasizes its utility in emboli detection of other arteries based on a high accuracy and sensitivity.
Brain Metastases from Different Primary Carcinomas: An Evaluation of DSC MRI Measurements
Authors: Zhang H. , Zhang G. , Oudkerk M.
Published: April 2015

This study evaluated the roles of different dynamic susceptibility contrast magnetic imaging (DSC MRI) measurements in discriminating between brain metastases derived from four common primary carcinomas. Thirty-seven patients with brain metastases were enrolled. Relative cerebral blood volume (rCBV), cerebral blood flow (rCBF) and relative mean transit time (rMTT) in both tumor and peritumoral edema were measured. Metastases were grouped by their primary tumor (lung, gastrointestinal, breast and renal cell carcinoma). DSC MRI measurements were compared between groups. Mean rCBV, rCBF, rMTT in tumor and peritumoral edema of all brain metastases (n=37) were 2.79 ± 1.73, 2.56 ± 2.11, 1.21 ± 0.48 and 1.05 ± 0.53, 0.86 ± 0.40, 1.99 ± 0.41, respectively. The tumoral rCBV (5.26 ± 1.89) and rCBF (5.32 ± 3.28) of renal metastases were greater than those of the other three metastases (P<0.05). The tumoral rMTT (1.58 ± 0.77) of breast metastases was statistically greater than that (0.96 ± 0.31) of gastrointestinal metastases (P=0.013). No statistical difference was found between peritumoral rCBV, rCBF and rMTT (P>0.05). Evaluating various DSC MRI measurements can provide complementary hemodynamic information on brain metastases. The tumoral rCBV, rCBF and likely rMTT can help discriminate between brain metastases originating from different primary carcinomas. The peritumoral DSC MRI measurements had limited value in discriminating between brain metastases.
Congenital X-linked Stapes Gusher Syndrome in an Infant
Authors: Muttikkal T.J. Eluvathingal , Nicolasjilwan M.
Published: April 2015

Congenital X-linked deafness with stapes gusher is a rare, but well-known clinical entity with characteristic radiological features. Recognition of these findings is important as it changes the treatment course and precludes stapedectomy, which if done can lead to stapes gusher in these patients. We present the case of a nine-month-old male infant with hearing loss. CT scan showed typical radiological features of X-linked stapes gusher syndrome. In addition, the superior semicircular canals appeared dehiscent which could be due to immature ossification or less likely due to defective development as part of the disease. To the best of our knowledge this is the youngest patient prospectively identified by imaging in the English medical literature.
Childhood Ataxia with Cerebral Hypomyelination Syndrome: A Variant of Patient with Early Childhood Onset Related to EIF2B3 Mutation
Authors: Perfetto F. , Stoppino L.P. , Calì A. , Milillo P. , Grilli G. , Vinci R. , Macarini L.
Published: April 2015

Childhood ataxia with central nervous system hypomyelination (CACH) syndrome is an autosomal recessive transmitted leukodystrophy characterised by early childhood onset and acute deterioration following febrile illnesses or head trauma. We describe the case of a child with early onset of CACH syndrome. He presented with cerebellar ataxia beginning around two years of age with mild mental retardation. MRI showed diffuse white matter signal changes with thinning of the corpus callosum.
A Simple and Fast Method of 3D Registration and Statistical Landmark Localization for Sparse Multi-Modal/Time-Series Neuroimages Based on Cortex Ellipse Fitting
Authors: Volkau I. , Puspitasari F. , Ng T.T. , Prakash K.N. Bhanu , Gupta V. , Nowinski W.L.
Published: April 2015

Existing methods of neuroimage registration typically require high quality scans and are time-consuming. We propose a simple and fast method which allows intra-patient multimodal and time-series neuroimage registration as well as landmark identification (including commissures and superior/inferior brain landmarks) for sparse data. The method is based on elliptical approximation of the brain cortical surface in the vicinity of the midsagittal plane (MSP). Scan registration is performed by a 3D affine transformation based on parameters of the cortex elliptical fit and by aligning the MSPs. The landmarks are computed using a statistical localization method based on analysis of 53 structural scans without detectable pathology. The method is illustrated for multi-modal registration, analysis of hemorrhagic stroke time series, and ischemic stroke follow ups, as well as for localization of hardly visible or not discernible landmarks in sparse neuroimages. The method also enables a statistical localization of landmarks in sparse morphological/non-morphological images, where landmark points may be invisible.
Atlas-Based Classification of Hyperintense Regions from MR Diffusion-Weighted Images of the Brain: Preliminary Results
Authors: Bilello M. , Lao Z. , Krejza J. , Hillis A.E. , Herskovits E.H.
Published: April 2015

The study of subjects with acquired brain damage in a specific location is important in exploring human brain function. Description of lesion locations within and across subjects is a crucial methodological component that usually involves the distinction of normal from damaged tissue (lesion segmentation) in relation to lesion locations in terms of a standard anatomical reference space (lesion mapping). Our study provides an atlas-based, computer-aided methodology for classification of hyperintense regions on diffusion-weighted images of the brain, representing either ischemic lesions or susceptibility artifacts. We applied a leave-one-out method of cross-validation that computed probabilistic atlases of true lesions and artifacts, based on training data. Our approach accurately classifies lesions and artifacts, but leaves a significant number of regions unclassified, due to the relatively small number of training samples. An initial segmentation step based on a larger sample of data sets is required to automate discrimination of lesions and artifacts.
Presurgical Identification of the Central Sulcus Using GE EPI Sequences in Combination with 3D Reconstruction is a Useful and Easy Technique for Functional Identification of the Sensorimotor Cortex
Authors: Lüttich A. , Parrilla G. , Espinosa M. , Zamarro J. , Larrea J.A. , Moreno A.
Published: April 2015

Functional magnetic resonance imaging (fMRI) is a noninvasive neuroimaging technique that enables the visualization of vascular changes originating in the cortex on the execution of a simple motor task. We aimed to assess the usefulness of sensorimotor fMRI using echo-planar imaging (EPI) techniques and assess its clinical usefulness in the identification of the central sulcus. We studied 32 candidates for neurosurgery who had centrally located space-occupying lesions with fMRI using EPI images with blood oxygen level-dependent (BOLD) gradient-echo (GE) sequences acquired on a 1.5T scanner while patients repeatedly opened and closed their hands. Statistical activation images (t images) corresponding to the movements of the right and left hands were compared using cancellation analysis. Three-dimensional reconstruction of the cranium and brain of each patient showed the relative position of the expansive lesion and of non-damaged cortical tissue. Reproducible and selective functional sensorimotor activation was observed in 32 patients. Validation was carried out by intraoperative mapping in 19 patients. Based on intraoperative confirmation data we assumed that functional MR imaging (fMRI) is a valid method for identifying the motor cortex. Nevertheless, a limitation to our study is that not all the patients received invasive cortical stimulation. It is also relevant to indicate that fMRI and intraoperative procedures coincide in the sulcus identified as the sensorimotor cortex. Neurological examination did not reveal postoperative motor/sensitive deterioration in the remaining patients. fMRI using GE EPI sequences in combination with three-dimensional reconstruction is a useful and easy technique for functional identification of the sensorimotor cortex.
Endovascular Management of Direct Carotid-Cavernous Sinus Fistulas
Authors: Lv X. , Li Y. , Yang X. , Jiang C. , Wu Z.
Published: April 2015

To evaluate the single-centre experience with endovascular management of direct carotid-cavernous sinus fistulas (DCCF). Between November 2008 and November 2010, a total of 14 patients (11 males) with direct carotid-cavernous sinus fistula underwent 16 transarterial treatment sessions. The patient files and angiograms were analysed retrospectively. Clinical signs and symptoms included exophthalmos [n=12, (85.7%)], pulsatile tinnitus [n=9, (64.3%)], cranial nerve III or VI palsy [n=2, (14.3%)], and impaired vision [n=1, (7.1%)]. Angiography revealed in addition cortical drainage in five patients (35.7%). Transarterial embolization was performed using detachable balloon in nine sessions (56.2%), detachable coils in three sessions (18.8%) and a combination with Onyx in four sessions (25%). Complete interruption of the arteriovenous shunt was achieved in all patients. There was a tendency for ocular pressure-related symptoms to resolve rapidly, while cranial nerve palsy and diplopia improved slowly (7.1%) or did not change (7.1%). The patient with visual impairment recovered within the first two weeks after endovascular treatment. After complete interruption of the arteriovenous shunt, two (12.5%) recurrences were observed in balloon treatment and retreatment was given. Transarterial management is a highly efficient and safe treatment in DCCFs. In the majority of patients a significant and permanent improvement in clinical signs and symptoms can be achieved.
Low-Dose Brain Computer Tomography Sensitivity: A Comparative Study with a Conventional Technique
Authors: Aprile I. , Ottaviano I. , Buono E. , Di Renzo A. , Fiaschini P. , Ottaviano P.
Published: April 2015

A comparative study between brain conventional computed tomography (CT) examinations and low-dose examinations was performed. The aim of the work was to show if a low-dose technique can be used instead of a standard one. Forty patients with 51 brain lesions were studied with both techniques. The low-dose technique was optimized with mAs reduction to obtain a 25% dose reduction compared to standard acquisitions. Even if images have a poor signal-to-noise ratio, the low-dose technique visualized all the lesions disclosed by conventional examination except three chronic vascular lacunar infarcts. In conclusion, the low-dose technique can be adopted instead conventional CT scans in selected cases.
Cervical Chordoma
Authors: Conforti R. , Taglialatela G. , Rinaldi F. , Quaranta E. , Cirillo M. , Paolisso G. , Cirillo S.
Published: April 2015

Chordomas are rare and aggressive tumors derived from notochordal remnants, usually arising in the axial skeleton. The most frequently reported anatomic distribution of chordoma is 50% sacral, 35% spheno-occipital and 15% spinal. We describe the case of an elderly lady presenting with progressive dysphagia, headache and neck pain. We found an expansile mass extending from C1 to C3. While running the diagnostic plan we considered a variety of lesions possibly involving the cervical spine. Biopsy revealed the mass was a chordoma.
Primary Skull Osteosarcoma: MDCT Evaluation and Histopathological Correlation in Two Cases
Authors: Gangadhar K. , Santhosh D.
Published: April 2015

Osteosarcomas are typically long bone tumors and rarely affect the skull, with most articles reporting single cases. As elsewhere in the body, these lesions may be classified as primary or secondary, chiefly post-Paget and post-radiation therapy. We describe two cases of primary osteosarcoma of skull one presenting with cerebellar symptoms and another with giant skull swelling. Complete evaluation with 64 slice CT and histopathological correlation was carried out.
Stable Neurocutaneous Melanosis in a Ten-Year-Old Boy with Controlled Partial-Complex Seizures
Authors: El Beltagi A.H. , Fahmy H. , Nasef N. , Norbash A. , Abdalla D.
Published: April 2015

Neurocutaneous melanosis (NCM) is a rare neuroectodermal dysplasia that includes both central nervous system (CNS) and integumentary melanocytic abnormalities. NCM can present with varied clinical and imaging findings, classically presenting with large melanocytic nevi involving the posterior axial trunk region. We describe a case with predominant small non-scalp and non posterior axial-trunk nevi, which nevertheless demonstrated typical CNS imaging findings. Our case clinically presented with epilepsy that was controlled by medical treatment. The patient also demonstrated motor developmental delay, and an otherwise stable course.
Spinal Subarachnoid Hemorrhage Mimicking an Acute Abdomen
Authors: Neto L. , Guedes M. Moura , Campos J.
Published: April 2015

A 39-year-old woman with a history of systemic lupus erythematosum developed an acute abdomen. An intestinal ischemia was suspected and an exploratory laparotomy was performed. No abnormalities were found during surgery and five days later the patient was transferred to our institution. On admission, the patient presented a distended abdomen and paraparesis. The spinal tap showed hemorrhagic CSF and the MRI a subacute subarachnoid hemorrhage (SAH) of the dorsal-lumbar spine. Two days later, the patient suffered an episode of sudden headache. The CT scan revealed an acute SAH at the posterior fossa and digital subtraction angiography a dissection of the right V4 segment. Spinal subarachnoid hemorrhage is a rare syndrome particularly when associated with dissecting aneurysms of the intracranial segment of the vertebral artery. SSAH should be considered early in the differential diagnosis of any case with sudden back or abdominal pain of unknown etiology, even in the absence of neurological deficits.
Spontaneous Ruptured Cavernous Aneurysm Treated by Stenting and Embolization in a Young Patient
Authors: Viglianesi A. , Chiaramonte R. , Messina M. , Conte G. , D'Amore A. , Serra A. , Grillo C. , Chiaramonte I.
Published: April 2015

We describe a case of endovascular management of a ruptured aneurysm of the intracavernous portion of the left internal carotid artery with sphenoid extension. The exclusive use of coils to embolize the aneurysm in acute and young patients offers the advantage of avoiding both pre-implant antiplatelet therapy and long-term anticoagulant therapy required after stent or vascular plug placement, but it is complicated by the non-negligible risk of recurrence. Indeed, the only secure method to treat ruptured aneurysms of the intracavernous portion of the internal carotid artery is to use coils in the first stage to stop the haemorrhage without antiplatelet therapy and to use stents in the second narrow stage to prevent revascularization.
Coils and Onyx Embolization of Traumatic Carotid-Cavernous Fistula Caused by an Intradural Internal Carotid Artery Pseudoaneurysm
Authors: Zhao P. , Liu L. , Jiang C. , Jiang P. , Yang X.
Published: April 2015

A rare case of traumatic carotid-cavernous fistula caused by an intradural internal carotid artery pseudoaneurysm arising from the intradural internal carotid artery is described. The presentation was similar to that of carotid-cavernous fistulae, with ocular pain, chemosis and proptosis being the common symptoms. The patient was successfully treated by transarterial coil and Onyx-34 embolization. A 40-year-old man presented with severe injury, including multiple fractures of ribs, clavicle scapula and blind left eye. He gradually recovered and was discharged after intensive treatment in a local hospital. But about 70 days after discharge, his left eye became gradually chemotic and he felt a pulsatile bruit in his left ear. A CT scan and DSA confirmed a large intradural pseudoaneurysm and the associated carotid-cavernous fistula. Angiography revealed a fistula between the intradural aneurysm and the cavernous sinus. The origin of the aneurysm was above the posterior communicating artery. The aneurysm was successfully obliterated with detachable coils and Onyx-34 with the protection of a Hyperglide balloon. Subsequent studies demonstrated no flow through the fistula and good opacification of the ipsilateral internal cerebral artery system. Intradural pseudoaneurysm associated with carotid-cavernous fistula is a rare sequel of trauma. It may be treated successfully with the use of transarterial coil and Onyx embolization.
Passing the Thrombus in Endovascular Treatment of Acute Ischemic Stroke: Do We Penetrate the Thrombus?
Authors: Mordasini P. , Brekenfeld C. , Fischer U. , Arnold M. , El-Koussy M. , Schroth G. , Mattle H.P. , Gralla J.
Published: April 2015

Mechanical thrombectomy is increasingly applied during the treatment of acute stroke. Various devices have been advocated with different sites of force effect at the thrombus. The purpose of this study was to evaluate the angiographic route of passing systematically and therefore to assess the site of deployment of mechanical devices in correlation to the thrombus in interventional stroke treatment. Twenty-one consecutive patients with endovascular treatment for acute ischemic stroke with 26 passing procedures were evaluated prospectively. Occlusion site was the M1-segment in 17 cases (65.4%), ICA termination in five cases (19.2%), M2-segment in two cases (7.7%), the A2-segment in one case (3.8%) and basilar artery in one case (3.8%). On angiographic images the microwire and microcatheter passage was evaluated by illustrating the entry point and course across the occlusion site in relation to the thrombus in different projections and in correlation to the recanalisation result. Results were correlated to the origin of the thrombi according to the TOAST criteria. In all cases the point of entry to the occlusion site was delineated laterally to the thrombus in at least one projection. The course of the wire across the occluded segment in relation to the thrombus was found to be laterally in 22 procedures (84.6%). In the majority of M1-occlusions (12/17, 70.6%) the passage was found in the cranial aspect of the thrombus. In four procedures (15.4%) angiograms in different projections did not unequivocally confirm a passage laterally to the thrombus. The route of passing the thrombus was independent of thrombus origin according to the TOAST criteria. In the majority of cases the complete route of passing the occlusion site was visualized angiographically. Entrance of the microwire and microcatheter at proximal surface of the thrombus takes place laterally to the thrombus and accordingly the passage takes place between the thrombus and the vessel wall independent of thrombus origin. A penetration of the thrombus was not observed. This route of passing has implications on deployment and transmission of force in relation to the thrombus in mechanical approaches and consequently on the development of retrieval devices.