bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Concepts in the Molecular Mechanisms and Management of
Diabetic Neuropathy by Pharmacotherapeutics and Natural Compounds
Authors: Shivam  , Gupta Asheesh Kumar , Kumar Sushil
Published: March 2024

:

One of the most crippling effects of diabetes mellitus is diabetic neuropathy, which can
cause discomfort, loss of movement, and even amputation. Diabetic neuropathy manifests in a variety
of ways, ranging from pain to death. Diagnosing diabetic neuropathy can be challenging since
it often goes unnoticed for many years following the onset of diabetes. In addition to oxidative
stress in neurons, hyperglycemia activates a number of metabolic pathways that are important
sources of damage and possible targets for treatment in diabetic neuropathy. Downstream metabolic
cascades caused by prolonged hyperglycemia include activation of protein kinase C, increased
production of advanced glycation end products, excessive release of cytokines, increased oxidative
stress, and injury to peripheral nerves. Despite the fact that these metabolic anomalies are considered
the main cause of diabetes-related microvascular issues, the diverse mechanistic processes of
neuropathy are characterized by organ-specific histological and biochemical features. Although the
symptoms of diabetic neuropathy can be treated, there are few options to correct the underlying
problem. Diabetic neuropathy exerts a tremendous financial, psychological, and physical burden on
society, emphasizing the need for efficient and focused treatment. The major goal of this review is
to shed light on the multiple mechanisms and pathways that contribute to the onset of diabetic neuropathy
and to provide readers with a comprehensive understanding of emerging therapeutic strategies
to postpone or reverse various forms of diabetic neuropathy. The article discusses available
medications and provides the latest guidelines for the treatment of pain and distal symmetric polyneuropathy,
including diabetic autonomic neuropathy, which may help the patients control pain
well and assess alternatives for treatment that might be more successful in preventing or delaying
the course of a disease.
WITHDRAWN: Exploring The Diverse Therapeutic Potentials of
Synthetic Analogues of Keto-terpenoids (+) Carvone: A Future Scaffold
Authors: Srivastava Snigdha , Sinha Reema , Kaushik Rahul , Kurmi Rajan Kumar
Published: March 2024

The article has been withdrawn at the request of the authors of the journal "Central Nervous System Agents in Medicinal
Chemistry" as a conflict has arisen among the authors in adding another author at the later stage of publication.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Nanomedicine: A New Frontier in Alzheimer’s Disease Drug Targeting
Authors: Pathak Kalyani , Ahmad Mohammad Zaki , Saikia Riya , Pathak Manash Pratim , Sahariah Jon Jyoti , Kalita Parimita , Das Aparoop , Islam Md Ariful , Pramanik Pallab , Tayeng Dubom , Abdel-Wahab Basel A.
Published: March 2024

:

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder affecting elderly individuals,
characterized by progressive cognitive decline leading to dementia. This review examines
the challenges posed by anatomical and biochemical barriers such as the blood-brain barrier
(BBB), blood-cerebrospinal fluid barrier (BCSFB), and p-glycoproteins in delivering effective
therapeutic agents to the central nervous system (CNS) for AD treatment.

:

This article outlines the fundamental role of acetylcholinesterase inhibitors (AChEIs) and
NMDA(N-Methyl-D-Aspartate) receptor antagonists in conventional AD therapy and highlights
their limitations in terms of brain-specific delivery. It delves into the intricacies of BBB and pglycoprotein-
mediated efflux mechanisms that impede drug transport to the CNS. The review further
discusses cutting-edge nanomedicine-based strategies, detailing their composition and mechanisms
that enable effective bypassing of BBB and enhancing drug accumulation in brain tissues.

:

Conventional therapies, namely AChEIs and NMDA receptor antagonists, have shown limited efficacy
and are hindered by suboptimal brain penetration. The advent of nanotechnology-driven therapeutic
delivery systems offers promising strategies to enhance CNS targeting and bioavailability,
thereby addressing the shortcomings of conventional treatments.

:

Various nanomedicines, encompassing polymeric and metallic nanoparticles (MNPs), solid lipid nanoparticles
(SLNs), liposomes, micelles, dendrimers, nanoemulsions, and carbon nanotubes, have
been investigated for their potential in delivering anti-AD agents like AChEIs, polyphenols, curcumin,
and resveratrol. These nanocarriers exhibit the ability to traverse the BBB and deliver therapeutic payloads
to the brain, thereby holding immense potential for effective AD treatment and early diagnostic
approaches. Notably, nanocarriers loaded with AChEIs have shown promising results in preclinical
studies, exhibiting improved therapeutic efficacy and sustained release profiles.

:

This review underscores the urgency of innovative drug delivery approaches to overcome barriers
in AD therapy. Nanomedicine-based solutions offer a promising avenue for achieving effective
CNS targeting, enabling enhanced bioavailability and sustained therapeutic effects. As ongoing research
continues to elucidate the complexities of CNS drug delivery, these advancements hold
great potential for revolutionizing AD treatment and diagnosis.
Nutritional Health Connection of Algae and its Pharmaceutical Value as Anticancer and Antioxidant Constituents of Drugs
Authors: Mirza Saima Shahzad , Akbar Sidra , Ijaz Muhammad Umar , Morowvat Mohammad Hossein , Ishaque Ayesha , Fatima Kalsoom
Published: March 2024

The marine environment is one of the major biomass producers of algae and
seaweed; it is rich in functional ingredients or active metabolites with valuable nutritional
health effects. Algal metabolites derived from the cultivation of both microalgae and
macroalgae may positively impact human health, offering physiological, pharmaceutical
and nutritional benefits. Microalgae have been widely used as novel sources of bioactive
substances. Bioactive polymers extracted from algae, such as algal fucans, Galatians, alginates
phenolics, carotenoids, vitamin B12, and peptides possess antioxidant, anticoagulant,
antimicrobial, antiviral, anti-inflammatory, anti-allergy, anticancer, and hypocholesterolemic
properties. It emphasizes that using marine-derived compounds with bioactive
properties as functional food ingredients may help promote human health and prevent
chronic diseases. Utilizing bioactive compounds has demonstrated notable advantages in
terms of effectiveness more than conventional treatments and therapies currently in use
which is also proven from different patents about algal applications in different fields.
Despite the availability of numerous microalgae-derived products catering to human
health and nutrition in the market, there remains a lack of social acceptance and awareness
regarding the health benefits of microalgae. Hence, this review aims to offer a comprehensive
account of the current knowledge on anticancers, antioxidants, commercially
available edible algal products and therapeutics isolated from algae.
An Experimental Investigation of Process Optimization of EDM for Newly Developed Aluminium Metal Matrix Composites
Authors: Kumar Jatinder , Singh Gurpreet , Kumar Santosh
Published: March 2024

The aim of this investigation is to investigate the contribution of controllable
input parameters (viz. pulse on times, peak currents) on the performance of two newly
developed MMCs (Al-8.5%SiC-1.5%Mo and Al-7%SiC-3%Mo). Both the metal
matrix composites were fabricated using the stir-casting method. Thereafter, various
tests such as microhardness test, tensile test, and porosity analysis of the newly
developed composite were performed. To carry out the machining trials, an L18
orthogonal array (OA) was chosen. Optimization of the machining process was
performed according to Taguchi analysis followed by grey relational analysis (GRA).
The results showed that with increasing weight fraction of the molybdenum
particulates, microhardness and density of the composites increase with a small
reduction in the tensile strength. In addition, pulse on time is the most contributing
parameter among others to obtain optimal process performance. The optimum setting
of input variables suggested by GRA to obtain optimal responses is a molybdenum
composition of 3%, Pulse on time of 70 µs, and a peak current of 9A. Based on the
interaction plot, it is evident that process performance measures of EDM depend on
controllable input parameters.
Barriers and facilitators to evidence-based practice adoption among healthcare practitioners
Authors: Aishammari Yousef Fehaid Hawas , Alharbi Mudi Naif , Alanazi Huda Fawaz , Aldhahawi Bandar Khulaif , Alshammari Fahad Mohammed , Alsuwaydan Rawaf Hussain , Alenezi Saad Ghanem , Alshammari Bandar Awad , Alshammari Rikan Mashan , Alshammari Brahim Madhour , Jabal Afnan Mohammed Bin
Published: March 2024

This research investigates the barriers and facilitators influencing the adoption of evidence-based practice (EBP) among healthcare practitioners. A comprehensive review of existing literature was conducted to identify key factors impacting the integration of EBP into clinical practice. Barriers such as time constraints, lack of resources, and resistance to change were identified, alongside facilitators including organizational support, education, and access to evidence-based resources. Understanding these factors is crucial for developing strategies to promote the widespread adoption of EBP in healthcare settings, ultimately enhancing the quality and effectiveness of patient care.
CHRESTOMATY OF THE TREATMENT OF INGUINAL HERNIA
Authors: Куравська Юлія Сергіївна , Honchar M.G. , Kuchirka Y.M. , Melnyk I.V. , Churpiy I.K. , Fedoryka R.Ya. , Mishchuk V.V. , Dyakiv M.V.
Published: March 2024

Хірургічне лікування пахвинних гриж на сьогодні не має альтернативи. Операції з цього приводу за частотою посідають перше місце серед планових хірургічних втручань як у нашій країні, так і за кордоном. Це зумовлює медичну й соціальну значущість проблеми.

        У статті проведений історичний екскурс розвитку лікування пахових гриж, починаючи з древніх часів і до сьогодення.

       Підсумок досягнень медицини в лікуванні гриж схематично окреслив Оганес Зардарян (2019):

Авіцена, який жив приблизно на початку ХI століття, запропонував застосовувати аускультацію для диференціальної діагностики грижі й гідроцеле.

Уільям Саличет, який жив в 1250 році, був прихильником збереження яєчка при герніотомії.

Роланд з Парми у 1383 році запропонував вправляти защемлені грижі хворим лежачи на спині з незначно піднятим догори тазом.

Гай де Шауляк, який проживав у XIV столітті, автор книги «Chirugia Magna», помітив різницю між пахвинною і стегновою грижами. Він, так само як і Роланд, вірив у ручне вправлення грижі в положенні Тренделенбурга.

Габріель Фаллопій – відомий анатом, який вивчав жіночу статеву систему і описав фаллопієві труби, внаслідок спостережень відзначив високу розповсюдженість гриж у співаків і монахів.

Лоренц Гейстер, який проживав в Амстердамі у XVIII столітті, зробив перший опис прямої пахвинної грижі.

Петрус Кампер з Лейдена приблизно в той же час, що і Гейстер, описав ретельну хірургічну анатомію пахвинної грижі і поверхневий листок, який з передньої стінки безпосередньо переходить у відповідну фасцію стегна, промежини і в м’язову оболонку – фасція Кампера.

Франц Гессельбах описав зв’язку, яка отримала його ім’я, а також трикутник – місце виходу прямих пахвинних гриж.

У середині XIX століття брати Мейо запропонували спосіб операції пупкових гриж шляхом утворення дуплікатури апоневрозу в горизонтальному напрямку.

У той же час український хірург Кирило Михайлович Сапежко запропонував свій метод створення дуплікатури у вертикальному напрямку з накладанням поодиноких, а не П-подібних швів.

           Звичайно, це не повний перелік досягнень медицини за тисячоліття, але він дає певне уявлення про розвиток хірургії пахвинних гриж у світі.

        Висновки.

Важливим етапом подальшого розвитку хірургії пахвинних гриж є експериментальна розробка і впровадження у клінічну практику синтетичних та алопластичних матеріалів, застосування яких дозволить значно знизити відсоток рецидивів.

На сучасному етапі хірургії гриж, починаючи з 80-х років ХХ століття, підхід до лікування став диференційованим у кожному конкретному випадку, а методикою алопластики пахових гриж, яка стала «золотим стандартом», володіють практично всі хірурги сьогодення.
Impacto de las clases virtuales en la salud mental de la población pediátrica durante la pandemia de COVID-19 en septiembre-diciembre 2021
Authors: Jimenez Cedano Missel Maria , Gomez Guzman Paola Alejandra , Cepeda Marte Jenny , Morillo Zuleika
Published: March 2024

Introducción: El COVID-19 ha afectado la salud mental de la población pediátrica. Con la transición a la virtualidad, se han identificado posturas positivas y negativas. Debido a la diferencia de características sociodemográficas que posee la República Dominicana, es necesario describir el efecto de dichos cambios en la salud mental dentro de este contexto.
Objetivo: Evaluar el efecto de las clases virtuales en la salud mental de los pacientes pediátricos.
Metodología: Se utilizó el cuestionario de capacidades y dificultades en los pacientes que asistieron a consulta general. Se asignó una puntuación con la escala de puntuación estandarizada y se analizaron los resultados en gráficos de frecuencia y pruebas de correlación de spearman.
Resultados: Existe una frecuencia del 10,4% (n=34) de alto riesgo de desarrollar algún trastorno psiquiátrico. Se observaron correlaciones débiles entre menor edad y trastorno de conducta, r(365) = -0,111, p = 0,034, y sexo masculino y cualquier trastorno pediátrico, r(365) = -0,131, p = 0,012. Hay una incidencia de 51,5% de síntomas físicos. Un 45.5% y un 30.2% identificó mejores e iguales calificaciones.
Conclusión: Es necesario investigar los efectos identificados agregando la evaluación de especialistas para mayor precisión de los hallazgos observados.
Determinantes del estado de vacunación infantil: abordando la brecha de equidad en República Dominicana-2019
Authors: Colomé-Hidalgo Manuel , Herrera Demian , Brea Del Castillo José , Carrasco Sánchez Cecilia María , Dauhajre Pimentel Mariana F. , Jurcev Savicevic Anamarija , Ramírez Issael
Published: March 2024

Introducción: Las desigualdades amenazan el progreso del país hacia la equidad y la cobertura de vacunación infantil. Siendo la cobertura inferior a la meta del 90% de la Organización Mundial de la Salud.
Objetivo: Identificar los determinantes sociales y las desigualdades en el estado de vacunación infantil en República Dominicana, 2019.
Métodos: Se realiza un análisis basado en la Encuesta de Indicadores Múltiples por Conglomerados. Incluyendo una muestra ponderada de 1674 niños de 12-23 meses. Se calcula la regresión logística multinomial para identificar factores asociados a la vacunación. Adoptando p<0,05 para significación estadística. Utilizando una razón de probabilidades ajustada con intervalo de confianza del 95%. Empleando HEAT 4.0 para medir desigualdades y SPSS.23 para gestión y análisis de datos.
Resultados: La edad media de los niños fue 17,4±3,5 meses. El 33% de ellos estaban completamente vacunados. La cobertura fue significativamente menor entre hijos de madre sin educación [AOR= 7,27; IC95%= 2,98–17,74]. La mayor cobertura se concentra en niños con altos niveles de educación y riqueza.
Conclusión: Para lograr una cobertura de vacunación completa y equitativa, las intervenciones de salud pública deben diseñarse para satisfacer las necesidades de grupos de alto riesgo.
Evaluation of the White Garden Snail (Theba pisana) Mucus Slime for its Efficacy as an Antimicrobial Agent
Authors: Alarfaj Khuzama , Almatroudi Ahmad , Alrumaihi Faris , Rahmani Arshad Hussain , Khan Amjad Ali , Mohamed Hamid G. , Khan Masood Alam , Alalawi Shaden Abdullah , Alkhorayef Nada , Allemailem Khaled
Published: March 2024

The escalation of environmental pathogenic microorganisms and disregard of public hygiene practices have resulted in the emergence of various skin infections within communities. Recent investigations have proposed that diverse snail mucus compositions may possess antimicrobial properties. Therefore, it is imperative to conduct further research to elucidate specific antibacterial characteristics inherent in the mucus of White Garden snail (Theba pisana). This study aimed to evaluate antibacterial activity of Theba pisana mucus extract against selected ATCC bacterial strains being Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and MRSA. The assessment involved comparing antimicrobial activity of the mucus extract to various broad-spectrum antibiotics. The susceptibility of bacterial isolates to snail mucus secretions was assessed using agar well diffusion method on Muller Hilton Agar plates. After incubation at 37°C for 24 hours, various concentrations of snail slime including 100%, 75%, 50%, and 25% were applied. The findings reported that E. faecalis exhibited highest activity, with zone of inhibition measuring 24 mm, followed by K. pneumonia and S. aureus (16 mm), MRSA (14 mm), and E. coli (12 mm). However, at concentration of 25%, mucus extract exhibited effect only against E. faecalis. Moreover, the antimicrobial activity of several tested antibiotics demonstrated similarity to that of the mucus extract. Therefore, it revealed that secretions of T. pisana mucus may possess the potential to act as a source of antibacterial agents. This may become as an alternative agent to costly synthetic antibacterial compounds. However, further studies are required to exploit the mucus secretion in addressing the issue of antibiotic resistance.
ARTICLE ABOUT THE RELEVANCE OF INVOLVING YOUTH IN THE PROCESS OF URBAN SPACE DEVELOPMENT
Authors:   Vologda Scientific Center of the Russian Academy of Sciences, Zhdanova Angelina
Published: March 2024

The study is aimed at studying the importance of including youth in the formation and development of a comfortable urban environment. The research was carried out using textual content analysis of existing youth participation practices, as well as statistical data and regulatory documents. The concept of youth, its characteristics and life values have been studied. It is concluded that in the Vologda region there are no youth organizations directly involved in the development of urban space
ORGANIZATION OF LEGAL EDUCATION IN THE POST-SOVIET PERIOD (90S – 2000S)
Authors:   Bryansk State Academician I.G. Petrovski University, Zadorin Maxim
Published: March 2024

The article examines the organization of legal education in the post-Soviet period, from the 90s to the 00s. The fall of the socialist system and the emergence of new states led to changes in the educational sphere, including in the field of legal education. The article analyzes the key changes and challenges faced by educational institutions during this period. As a result of the study, the main trends in the organization of legal education were identified, such as the revision of curricula and programs, the integration of international human rights standards into national educational programs, as well as the active introduction of interactive teaching methods. The importance of strengthening interaction between educational institutions, government bodies and society to create the best conditions for legal education is analyzed. In addition, the article discusses changes in the content of education: from the formation of new curricula to the introduction of advanced teaching methods and new approaches to assessing educational outcomes. An important part of the article is also a discussion of the significance of the development of civil society and the formation of respect for human rights and freedoms through the education system in the post-Soviet context. Overall, the article provides an overview of the key changes and challenges that legal education has faced in the post-Soviet period and discusses the importance of these processes for the development of society as a whole.
DEMOGRAPHIC PROBLEM IN RUSSIA AND WAYS TO SOLVE IT, ADDITIONAL MEASURES TO SUPPORT LARGE FAMILIES
Authors:   Bryansk State Academician I.G. Petrovski University, Rodina Tatiana , Zabugina Anna ,   Bryansk State Academician I.G. Petrovski University, Usyakov Roman ,   Bryansk State Academician I.G. Petrovski University
Published: March 2024

This article is devoted to the characterisation of one of the urgent problems of our time, the demographic problem. In this article, we will explore the demographic problem in depth and focus on the important role that maternity capital plays in solving this problem. We will also propose ideas and strategies that can help strengthen the demographic situation in Russia and ensure a sustainable future for the country. A definition of the concept of "large family" is given to determine the most effective additional measures to support large families. Part of the work is based on analysing and clarifying the instruments of additional state support for large families in Russia, taking into account the social and demographic situation. It is concluded that it is necessary to develop and implement additional measures of support for large families to overcome the trend of depopulation in Russia.
Environmental sustainability and operational performance in the road freight sector
Authors: Mlambo Munyaradzi , Mageto Joash , Thaba Sebonkile
Published: March 2024

Road freight plays a pivotal role in the movement of goods from the point of production to the point of consumption. Transportation of freight by road is associated with high operational costs which increases cost of landed goods. The use of trucks is associated with greenhouse gas (GHG) emissions and congestion especially in urban areas. The trucking industry dominates freight movement in many countries including South Africa, necessitating the need to improve its operational performance. While researchers argue that implementation of environmentally sustainable practices (ESP) by trucking firms is likely to influence operational performance (OP), the actual effect is unknown. The purpose of this study was to investigate the effect of ESPs on OP among trucking firms. A survey of 124 trucking firms was conducted and the data was analysed using canonical correlation analysis. The ESPs identified were energy efficiency, driver behaviour, and advanced technology. The results revealed that there is an inverse relationship between ESPs and OP, with advanced technology being a major contributing practice to the relationship. Limited funding was identified as a major inhibitor to the implementation of ESPs among the trucking enterprises. This study informs managers of trucking enterprises that the implementation of environmentally sustainable practices would not likely result in higher operational performance, as such, they should implement the practices as a social good as opposed to for profits. The study investigated a complex phenomenon in an important sector of the economy in South Africa and provide some policy directions.
Sustainable logistics and passenger transport in smart cities
Authors: Prokopenko Olha , Prause Gunnar , Bielialov Taliat , Jarvis Marina , Holovanenko Mykola , Kara Inna
Published: March 2024

The rapid growth of urban populations, coupled with the imperatives of decarbonization and the relentless march of urbanization, has thrust modern cities into a crucible of multifaceted challenges. In response, the Smart City concept has emerged as a shared paradigm for addressing these urban complexities. This transformative approach touches upon various facets of urban life, encompassing areas such as the economy, education, and governance. Among these, logistics stands out as a pivotal component of the Smart City framework, necessitating innovative and sustainable solutions. This article delves into the intricate nexus between sustainable logistics systems and the evolution of the Smart City concept. Drawing from both qualitative and quantitative research methodologies, including multivariate analysis, the study synthesizes data from primary sources collected during a series of European projects conducted from 2020 to 2023, in addition to secondary data sources. A central inquiry revolves around the symbiotic relationship between e-commerce dynamics and the sustainability of smart city logistics solutions. The findings of this investigation illuminate a compelling correlation between the profitability of logistics enterprises and the key indicators of logistics development underpinning smart cities. By unveiling these interdependencies, this research contributes to our understanding of how sustainable logistics and passenger transport systems are pivotal to the ongoing development of smart cities, offering valuable insights for urban planners, policymakers, and industry stakeholders alike.
Analysis of corporate management risks in the work of logistics enterprises
Authors: Maharram Quliyev Vaqif , Agamamed Abbasova Sevinj , Shaban Aliyeva Mehriban , Robert Samedova Elnara , Aziz Mammadova Manzar
Published: March 2024

Relevance of the problem. Complexity in the global supply chain increase the risks that enterprises are exposed to, including logistics. Purpose of the article. The article analyzes the corporate management risks of logistics enterprises. Methods. The article used the method of statistical groupings and statistical tables, the game theory method, the matrix game method. Main results. The study substantiates an algorithm for the analysis of corporate management risks of using blockchain technologies in the activities of logistics companies when concluding smart contracts, certifying new types of transportation, and integrating cryptocurrency for delivery payments. Examples of choosing an economic strategy for managing the risks of a logistics company using the criteria of maximax, Laplace, Wald, Savage, Bayesian, Hurwicz were elaborated. Referring to the relevant calculations, it was determined that the most often recommended strategy was “the certification of new types of logistics services”. It was determined that this strategy will contribute to minimizing the logistics company's risks associated with the implementation of blockchain technology through ensuring the competitive position through innovation. Practical relevance. The findings can be useful for managers of logistics companies in practical implementation and use of blockchain technologies as well as in risk management. It is expedient to focus the further research prospects onto the integration of blockchain technology with modern logistics companies’ ERP systems in the further developing the Logistics 4.0 concept.
The constructivist approach as a concept of active learning and teaching of optimization processes at technical universities
Authors: Lascsakova Marcela
Published: March 2024

As we move toward a more competitive global economy, the demand for highly qualified people to create and manage more efficient logistics systems, such as flows and management of materials or information, human flows, and supply chains, increases. Without logistics, the commercial world would grind to a halt. Businesses depend on logistics professionals to keep production and delivery moving forward which makes logistics education crucial. Companies expect their future employees to gain practical information, and to master what they are learning. Students must know how to apply what they learn. This is a reason why increasing importance is attributed to the constructivist approach to teaching and learning in university education. Through experiments or simulation of processes, and group work based on previous experience and knowledge, students better uncover the laws of phenomena. By actively engaging in the learning process, deeper and long-term applicable knowledge about the studied processes is acquired. The goal of this article is to implement the constructivist approach in the education of operational research and logistics at technical universities.
Efektivitas Model Pembelajaran Missouri Mathematics Project (MMP) Terhadap Kemampuan literasi Matematika Siswa Ditinjau dari Self-Efficacy
Authors: Setyowati Elis , Nurcahyo Adi
Published: March 2024

Indonesia merupakan negara dengan kemampuan literasi matematika tergolong rendah. Perbaikan model pembelajaran merupakan suatu tindakan yang dapat dilakukan untuk meningkatkan kemampuan literasi matematika siswa. Pendekatan pembelajaran Missouri Mathematics Project (MMP) termasuk pendekatan pembelajaran yang dinilai efektif meningkatkan kemampuan literasi matematika. Selain hal tersebut, self-efficacy merupakan faktor lain yang dapat mempengaruhi kemampuan literasi matematika siswa. Tujuan dari penelitian ini yaitu untuk mengetahui efektivitas model pembelajaran Missouri Mathematics Project (MMP) terhadap literasi matematika siswa ditinjau dari self-efficacy. Penelitian ini menggunakan pendekatan penelitian kuantitatif dengan metode kuasi eksperimen. Instrumen penelitian menggunakan essay tes dan kuesioner. Uji hipotesis menggunakan uji Anova Dua Jalan Sel Tak Sama. Hasil penelitian diperoleh Fhitung = 0,106 < Ftabel = 4,001 yang berarti H0 diterima. Hal tersebut berarti baik model pembelajaran konvensional maupun model pembelajaran Missouri Mathematics Project (MMP) siswa dengan kategori self-efficacy tinggi memiliki kemampuan literasi matematika lebih unggul dibandingkankan dengan siswa kategori self-efficacy sedang ataupun rendah. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh model pembelajaran Missouri Mathematics Project (MMP) dan self-efficacy terhadap literasi matematika siswa.
SOSIALISASI UPAYA PREVENTIF PENYEBARAN CORONAVIRUS DISEASE 2019 (COVID-19) di SMAN 15 MUARO JAMBI
Authors: Sitanggang Hendra Dhermawan , Kalsum Ummi , Wisudariani Evy
Published: March 2024

Coronavirus Disease 2019 (COVID-19) is still a global public health problem. However, Indonesia has decided to conduct Face-to-face Learning in the learning process. Schools need to implement strict health protocols to prevent the spread of COVID-19 in the school. Schools (teachers and education personnel) have an essential role in monitoring and ensuring the implementation of health protocols. Therefore, socialization about preventing the spread of Coronavirus Disease 2019 (COVID-19) must be done at SMAN 15 Muaro Jambi Regency. The target of the socialization was teachers and education staff at SMAN 15 Muaro Jambi Regency. The Pondok Meja Health Center and the community service team delivered the socialization material using lecture and discussion methods. This activity also measures knowledge before and after socialization. Data were analyzed univariate and bivariate using the Wilcoxon test. Seventeen teachers and education staff attended the socialization activity. The results showed that respondents' average level of knowledge before socialization was 7.94, with a standard deviation of 0.899, and after socialization was 8.35, with a standard deviation of 1.455. The Wilcoxon test showed no difference in the respondents' knowledge before and after socialization. However, there was an increase in the average level of knowledge before and after, from 7.94 to 8.35. Through this socialization, it is hoped that schools can improve the implementation of COVID-19 prevention efforts in schools during face-to-face learning.
PEMBERDAYAAN SANTRI SEBAGAI PEER EDUCATOR DALAM PERILAKU HIDUP BERSIH DAN SEHAT DI PONDOK PESANTREN IRSYADUL IBAD
Authors: Sari Puspita , Nasution Helmi Suryani , Sayuti Solihin
Published: March 2024

Adolescence is a transition period from childhood to adulthood, this triggers the emergence of complex health problems in adolescents as a result of the risky behavior they engage in. Technological progress in the world is very rapid, including in Indonesia, with rapid technological developments, adolescent problems in Indonesia are also developing. There are positive things and also negative things in various big cities in Indonesia, around 20 to 30 percent of teenagers admit to having had sex. Youth Posyandu is a form of Community Resource Health Effort (UKBM) which is managed and organized by, by, for and with the community including teenagers in implementing health development to improve the health status and healthy living skills of teenagers. The aim of establishing adolescent health cadres is to provide a platform to facilitate adolescent health needs. The aim of this community service is to increase the role of teenagers in planning, implementation and evaluation, as well as creating a forum for coaching and understanding the importance of a healthy lifestyle. The method used is education about clean and healthy living behavior and training. This service was carried out at the Irsyadul Ibad Islamic boarding school with a target number of 35 students. Activities are carried out with a pre-test stage, an education and discussion implementation stage and an evaluation stage with a post-test. PkM activities with pre-test scores obtained with a comparison mean score between pre-test and post-test was 1.50. There were also 27 (76%) respondents whose knowledge increased, 6 (17%) respondents whose knowledge remained unchanged and 3 (7% ) respondents whose knowledge decreased. The results of the bivariate analysis test with the Wilcoxon T-Test on Pre-test and Post-Test respondents. The results of data testing show a p value = 0.000 <0.05, so it can be concluded statistically that there is a significant difference in knowledge between knowledge before and after training
Kajian Yuridis Putusan Mahkamah Konstitusi Nomor 91/PUU-XVIII/2020 Tentang Undang-Undang Cipta Kerja
Authors: Hirma Hirma , Syamsir Syamsir
Published: March 2024

Penelitian ini bertujuan 1) untuk mengetahui alasan Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja menjadi inkonstitusional bersyarat, 2) untuk mengetahui Implikasi hukum terhadap Putusan Mahkamah Konstitusi Nomor 91/PUU-XVIII/2020 tentang Undang-Undang Cipta Kerja. Metode penelitian yang digunakan adalah tipe penelitian yuridis normatif. Hasil penelitian menunjukan bahwa 1) Dalam Putusan Mahkamah Konstitusi Nomor 91/PUU-XVIII/2020, Mahkamah Konstitusi memutuskan bahwa UU Cipta Kerja dinyatakan cacat secara formil, dan dinyatakan inkonstitusional bersyarat karena tidak memenuhi prosedur pembentukan UU sebagaimana diatur dalam UU P3 khususnya berkaitan dengan kewenangan lembaga negara, teknik pembentukan, teknis penulisan, asas pembentukan peraturan dan partisipasi masyarakat, 2) implikasi hukum terhadap putusan tersebut bahwa pemerintah dan DPR harus melakukan perbaikan terhadap UU Cipta Kerja dalam jangka waktu 2 tahun pasca putusan dibacakan, jika perbaikan tersebut tidak selesai, demi kepastian hukum. Seluruh ayat, pasal, maupun undang-undang yang dicabut dengan keberlakuan UU No. 11 Tahun 2020 tentang Cipta Kerja dinyatakan berlaku kembali, serta dalam waktu perbaikan, UU Cipta Kerja masih berlakua dan tidak diperbolehkan membentuk peraturan pelaksana ataupun mengambil kebijakan strategis berdasarkan UU Cipta Kerja sampai dengan tenggang waktu yang ditentukan.
IMPLEMENTASI PERATURAN DAERAH KOTA JAMBI TENTANG PENYELENGGARAAN KEPARIWISATAAN DALAM PERTANGGUNGJAWABAN KESELAMATAN PENUMPANG
Authors: Marivick Jefri , Putra Firmansyah
Published: March 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis tentang Implementasi Terhadap Peraturan Daerah Kota Jambi Nomor 15 Tahun 2017 Tentang Penyelenggaraan Kepariwisataan Dalam Pertanggungjawaban Keselamatan Penumpang dengan adanya kejadia kecelakaan ketek hias yang terjadi di kawasan wisata danau sipin pada tanggal 22 februari 2022. Penelitian ini merupakan penelitian empiris dengan pendekatan perundang-undangan dan konseptual yang disusun secara deskripstif untuk menghasilkan solusi berdasarkan permasalahan yang dikaji. Pasal 49 huruf c dan d Pasal 53 huruf d bahkan secara jelas mengatur bahwa setiap pengusaha yang menyelenggarakan usaha wisata harus memberikan kenyamanan, keramanan, perlindungan keamanan dan keselamatan wisatawan. Akan tetapi setelah dilakukan penelitian para pengemudi ketek hias masih ada yang tidak mengikuti aturan tersebut dan masih ada oknum pengemudi ketek hias yang memuatkan penumpang ketek hias melebihi kapasitas maksimal ketek hias.Kata Kunci: Kepariwisataan, Ketek Hias, dan Keselamatan Penumpang
IMPLIKASI PENGATURAN SISTEM PROPOSIONAL PEMILU TERHADAP PENYELESAIAN SENGKETA PEMILU DPR DAN DPRD DI INDONESIA
Authors: Eriton Muhammad
Published: March 2024

Pemilihan Umum di Indonesia sebelum Pemilu tahun 2024 ini telah dilaksanakan sebanyak duabelas kali Pemilu. Pimpinan DPR RI menyoroti usulan perubahan sistem pemilu yang akan digunakan pada Pemilu 2024. Salah satu bentuk sengketa Pemilu adalah sengketa penghitungan suara yang diperoleh peserta Pemilu,oleh karena itu tertarik untuk mengkaji lebih lanjut mengenai implikasi pengaturan sistem Proposional yang digunakan pada Pemilu di Indonesia terhadap PHPU. Teori yang digunakan pada penelitian ini adalah Demokrasi dan legal standing. Penelitian ini merupakan penelitian yuridis normatif. Kesimpulannya adalah (1) terdapat dua jenis sistem di dalam sistem proporsional yaitu sistem proporsional terbuka dan sistem proporsional tertutup.Pemberian legal standing bagi calon anggota DPR dan DPRD dalam perkara PHPU sejak dikeluarkannya PMK Nomor 2 Tahun 2018. (1) di indonesia pernah menggunakan kedua sistem Proposional. Melalui Undang-Undang Nomor 12 Tahun 2003, sistem proporsional tertutup diganti dengan sistem proporsional terbuka dan terus dipakai. dengan adanya peraturan MK nomor 2 tahun 2018 akan menambah kekuatan peran partai politik dalam Perselisihan Hasil Pemilihan Umum Anggota DPR dan DPRD. Saran nya adalah Sistem Proposional tertutup akan mengurangi bahkan meniadakan sengketa PHPU yang diajukan oleh perseorangan. Dan Pemberian Pemberian legal standing haruslah dikembalikan ke Partai Politik saja
ANALISIS YURIDIS KEWENANGAN SEKRETARIS DAERAH DALAM PENYELENGGARAAN PEMERINTAHAN DAERAH BERDASARKAN PERATURAN PERUNDANG-UNDANGAN
Authors: Ripaldi Riyan , Priskap Ridham
Published: March 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis kewenangan Sekretaris Daerah pada tingkat Kabupaten dalam penyelenggaraan Pemerintahan Daerah berdasarkan Peraturan Perundang-Undangan. Adapaun rumusan masalah dalam penelitian ini adalah 1). Bagaimana Pengaturan Kewenangan Sekretaris Daerah Kabupaten Dalam Penyelenggaran Pemerintahan Daerah? 2). Bagaimana Bentuk Kewenangan Sekretaris Daerah Kabupaten Dalam Penyelenggaraan Pemerintahan Daerah?. Metode penelitian ini adalah penelitian hukum normatif dengan menggunakan pendekatan peraturan perundang-undangan, pendekatan konseptual. Dari penelitian yang dilakukan dapat ditarik kesimpulan bahwa pengaturan kewenangan Sekretaris Daerah tidak berada pada satu simpul peraturan perundang-undangan melainkan terdapat dalam banyak peraturan perundang-undangan baik secara horizontal maupun vertikal dan kewenangan tersebut diatur di dalam peraturan pelaksana dari Undang Nomor 23 Tahun 2014 tentang Pemerintahan Daerah dan Undang Nomor 5 Tahun 2014 tentang Aparatur Sipil Negara. Pada peraturan perundang-undangan tersebut tidak disebutkan secara eksplit bahwa Sekretaris Daerah mempunyai kewenangan, melainkan menggunakan istilah kata seperti pejabat berwenang dan lain sebagainya. Kedudukan Sekretaris Daerah Kabupaten adalah sebagai Perangkat Daerah yang bertugas membantu Kepala Daerah Kabupaten (Bupati) dalam penyelenggaraan pemerintahan daerah. Kewenangan Sekretaris Daerah Kabupaten diperoleh dengan cara atribusi, delegasi dan mandat,akan tetapi substansi kewenangan tersebut masih sangat sempit dan terbatas. Terkait dengan bentuk kewenangan yang dimiliki oleh Sekretaris Daerah karena kedudukannya bertugas utama sebagai pembantu Kepala Daerah maka dalam banyak hal kewenangan tersebut berupa kewenangan mandat serta secara subtsansi sangat terbatas dari kekuasaan Sekretaris Daerah atas kewenangan tersebut, selain itu juga karena berkedudukan dibawah dan bertanggung jawab langsung kepada Kepala Daerah maka sumber kewenangan lahir dari dua cara yaitu berupa Peraturan Kepala Daerah dan Surat Keputusan Kepala Daerah.
PENGAKUAN DAN PERLINDUNGAN MASYARAKAT HUKUM ADAT BERDASARKAN PERATURAN PERUNDANG- UNDANGAN
Authors: Aldi Muhammad , Putra Firmansyah
Published: March 2024

Penelitian ini bertujuan untuk  mengetahui dan menganalisis bagaimana bentuk pengakuan dan perlindungan masyarakat hukum adat berdasarkan dengan peraturan perundang-undangan republik indonesia. Adapun yang menjadi perumusan masalah dalam penulisan skripsi ini adalah bagaimana pengaturan masyarakat hukum adat sistem hukum indonesia? Dan bagaimana Kedudukan Hukum (Legal Standing) Masyarakat Hukum Adat di Indonesia ? Metode penelitian penulisan skripisi ini adalah Penelitian Ini Merupakan Penelitian Yuridis Normatif yaitu penelitian terhadap norma-norma hukum, asas-asas hukum dan sistematika hukum yang berhubungan dengan sistem ketatanegaraan Indonesia.  Hasil penelitian ini adalah negara mengakui eksistensi masyarakat hukum adat di negara republik indonesia, hal ini jelas tercantum didalam Undang-Undang Dasar Negara Republik Indonesia Tahun 1945. Lebih tepatnya tercantum didalam Pasal 18B Ayat (2) Undang-Undang Dasar Negara Republik Indonesia. Namun sampai saat ini belum ada Undang-Undang yang secara khusus mengatur masyarakat hukum adat. Sehingga sampai saat ini entitas masyarakat hukum adat masih dalam keadaan yang belum jelas kedudukan hukumnya terutama di sistem tata hukum negara republik Indonesia. Dan persoalan pokok yang sampai saat ini masih menjadi perbincangan adalah mengenai peristilahan yang digunakan peraturan perundang-undangan untuk mendefinisikan masyarakat hukum adat yang belum mendapat penjelahan mengenai istilah masyarakat hukum adat tersebut. Masyarakat hukum adat selama ini belum dilindungi secara optimal oleh konstitusi republik indonesia. belum optimalnya pengakuan dan perlindungan masyarakat hukum adat ini mengakibatkan tidak tercapainya kesejahteraan bagi masyarakat hukum adat dan munculnya konflik di masyarakat hukum adat sehingga dapat menimbulkan ancaman stabillitas keamanan nasional.
Implementasi Pembentukan Peraturan DPRD Provinsi Jambi Berdasarkan Peraturan Pemerintah Nomor 12 Tahun 2018
Authors: Saputra M.Reza , Ansorullah Ansorullah
Published: March 2024

Abstract
This research aims 1) to find out and analyze the mechanism for forming DPRD Regulations in the Jambi Province DPRD after the enactment of Government Regulation Number 12 of 2018; 2) to find out and analyze the obstacles faced in the formation of Jambi Province DPRD regulations after the enactment of Government Regulation Number 12 of 2018. The research method used is empirical juridical research type. The results of the research show that the mechanism for forming DPRD regulations is based on Government Regulation Number 12 of 2018 concerning Guidelines for Preparing DPRD Rules and Regulations, that the absence of a mechanism for forming DPRD Regulations in the Jambi Province DPRD Regulations has had knock-on impacts. Based on temporary observations, the Jambi Provincial DPRD has not yet drafted a DPRD Regulation on the Code of Ethics as mandated by Article 63 of Government Regulation Number 12 of 2018. All members of the Jambi Provincial DPRD understand their function as forming legal products for the Jambi Provincial DPRD, but not all members understand how to form and draft legal products for the Jambi Province DPRD. And all the preparation of legal products for the Jambi Province DPRD is assisted by expert staff.
Keywords: Implementation, Establishment of DPRD Regulations, and Provinsi     Jambi.
Abstrak
Penelitian ini bertujuan 1) untuk mengetahui dan menganalisis mekanisme pembentukan Peraturan DPRD pada DPRD Provinsi Jambi sesudah berlakunya Peraturan Pemerintah Nomor 12 Tahun 2018; 2) untuk mengetahui dan menganalisis kendala-kendala yang dihadapi dalam pembentukan peraturan DPRD Provinsi Jambi sesudah berlakunya Peraturan Pemerintah Nomor 12 Tahun 2018. Metode penelitian yang digunakan adalah  tipe penelitian yuridis empiris. Hasil penelitian menunjukkan bahwa  mekanisme pembentukan peraturan DPRD berdasarkan Peraturan Pemerintah Nomor 12 Tahun 2018 Tentang Pedoman Penyusunan Tata Tertib DPRD bahwa tidak adanya pengaturan mekanisme pembentukan Peraturan DPRD dalam Peraturan DPRD Provinsi Jambi menimbulkan dampak ikutan. Berdasarkan pengamatan sementara, DPRD Provinsi Jambi sampai saat belum menyusun Peraturan DPRD tentang Kode Etik sebagaimana diamanatkan Pasal 63 Peraturan Pemerintah Nomor 12 Tahun 2018 Semua anggota DPRD Provinsi Jambi mengerti tentang fungsinya sebagai pembentuk produk hukum DPRD Provinsi Jambi, tetapi tidak semua anggota paham bagaimana membentuk dan meyusun produk hukum DPRD Provinsi Jambi. Dan semua penyusunan produk hukum DPRD Provinsi Jambi dibantu oleh staf ahli.
Kata kunci: Implementasi, Pembentukan Peraturan Dprd, Provinsi Jambi.
CONTAINING AN ISLAND: CORONAVIRUS (COVID-19) OUTBREAK IN PERHENTIAN ISLANDS, TERENGGANU STATE OF MALAYSIA, IN 2021
Authors: Abd Wahab Amer Taufek , Samsury Siti Fatimah , Awang Hafizuddin , Yaacob Effah Leiylena , Daud Arfizah Ahmad , Ishak Muhammad Solehuddin , Alias Nur Almas , Ghazali Nor Hafizah , Abdullah Ahmad Hanif , Abd Rahman Mohd Anuar , Embong Kasemani
Published: March 2024

Background: The spread of COVID-19 was inevitable and has not spared small and isolated communities, including the community of Perhentian Island in Besut District, Terengganu. Managing clusters in small islands can be difficult, given the limited resources. This study explores the characteristics of COVID-19 cases and the experience of outbreak containment at Perhentian Island.
THE ASSOCIATION BETWEEN ORGANIZATIONAL PSYCHOSOCIAL FACTORS WITH MUSCULOSKELETAL DISORDERS AMONG NURSES AT TERTIARY UNIVERSITY HOSPITAL
Authors: Baharudin Faiz , Isahak Marzuki , Abdul Majid Hazreen
Published: March 2024

Introduction: Musculoskeletal disorders (MSDs) was found to be high among nurses especially those working in the hospital. One of the risk factors of MSDs is psychosocial factors apart from physical and ergonomic factors. However, limited study was found specifically looking at this association among nurses working at tertiary university hospital especially in Malaysia. Hence, the objective of this study is to assess the association between organizational psychosocial risk factors with MSDs among nurses working at tertiary university