bluuebunny/crossref_metadata_2025 huggingface dataset:
Skull Base Osteomyelitis and Long Term Outcome
Authors: Basaran Seniha , Evlice Oguz , Benli Aysun , Simsek-Yavuz Serap , Çağatay Atahan , Öncül Oral , Özsüt Halit , Eraksoy Haluk
Published: August 2021

Objective: Skull base osteomyelitis (SBO) is a rare, life-threatening infection and frequently followed and treated by otolaryngologists previously. In this study, we analyzed the diagnosis, treatment and long-term outcomes of SBO from the perspective of infectious diseases and clinical microbiology (IDCM).

Methods: Hospitalized patients with SBO between 2012-2019 were evaluated retrospectively. Epidemiological, clinical, laboratory data of the patients were recorded. The patients who recovered with and without sequelae were compared.

Results: The mean age of 16 SBO cases was 66 years, 75% of them were male and 87.5% had diabetes mellitus (DM). Cranial nerve and vascular/dural involvement were present in 75% and 56.3% of them, respectively. The most common isolated microorganism were P. aeruginosa, staphylococci and Candida spp. 81.2%, 43.7%, and 56% of the patients received anti-pseudomonal antibiotics, additional glycopeptide and additional antifungal drugs, respectively. The sequelae rate was 46.7% in a 24-month follow-up. Hypertension (p=0.041), duration of complaints (p=0.003), bilateral involvement of skull base (p=0.001), vascular thrombosis/inflammation or dural involvement (p=0.007), previous surgical intervention (p=0.041) and elevated ESR at the end of treatment (p=0.014) were defined as risk factors for permanent sequelae. There was no in-hospital mortality. 

Conclusions: SBO mainly affects older male patients with DM and causes significant sequelae in half of them. In the cases unresponsive to anti-pseudomonal agents, the addition of antifungal therapy empirically may provide a clinical response. Permanent sequelae are more common in cases with delayed diagnosis/treatment, bilateral, vascular or dural involvement, and elevated ESR at the end of treatment.  ESR can be used to determine the treatment response and duration. The follow-up and treatment of SBO cases by IDCM with the support of experienced surgeons may contribute to the positive clinical results.
Perempuan Subaltern Dunia Ketiga Dalam Tinjauan Teori Feminisme Poskolonial Gayatri Chakravorty Spivak
Authors: Suryawati Indah , Seran Alexander , Sigit Ridzki Rinanto
Published: August 2021

Istilah subaltern dihadirkan sebagai sinonim kaum proletar. Gayatri Spivak menekankan   pentingnya   melihat   mekanisme hegemonik yang tidak  disadari  mengenai  penggunaan atribut kata subaltern. Mereka berada dalam wacana  hegemonik  yang  berarti  ada  semacam manipulasi secara tidak sadar atas apa yang mereka lakukan. Dalam kajian  teoritis  Spivak,  kelompok  subaltern  adalah  kelompok  yang suaranya selalu direpresentasikan, sementara representasi hanyalah alat untuk menuju dominasi nyata. Oleh karena itu, masyarakat yang tertekan dan terjajah (subaltern), harus berbicara, harus mengambil inisiatif, dan menggelar aksi atas suara mereka yang terbungkam. Karena kekuasaan kolonial terus dipertahankan dalam dan melalui discourse (wacana) yang berbeda-beda. Sebagai kritikus feminis poskolonial Gayatri Spivak terus menerus menantang pemikiran kontemporer Barat dengan menunjukkan betapa wacana-wacana dan praktik-praktik kelembagaan dan budaya dominan telah secara konsisten mengecualikan dan meminggirkan kaum jelata (subaltern), terutama perempuan subaltern. Fokusnya pada sejarah perempuan subaltern dan kritiknya terhadap proyek subaltern telah secara radikal menantang cara identitas politik dikonseptualisasikan dalam banyak pemikiran kontemporer. Penekannya pada kemampuan kaum subaltern untuk berbicara.
ESTIMATION OF THE POWDER-ACTUATED SHEAR CONNECTORS TESTS
Authors:   JSC «NITS «Stroitelstvo» Research Center of Construction, Konin D.V.
Published: August 2021

The shear connector design should be executed according to the SP 266.1325800.2016. For the different typed of welded connectors are there analytic dependences, which could be used for shear connection strength estimation. The design code also allows to use powder-actuated Z-shape shear connectors. Their bearing capacity should be proved by tests according to the GOST R 58336-2018. Inasmuch the GOST doesn't consist the test estimation approach, the authors offer the method. For the test estimation methods the test results of 15 series specimen had been used. The results were compared with estimation according to the European standard for the verification.
DIFFERENTIAL EQUATIONS OF EQUILIBRIUM OF IDEALLY ELASTOPLASTIC CONTINUOUS MEDIUM FOR PLANE ONE-DIMENSIONAL DEFORMATION IN APPROXIMATION OF CLOSING EQUATIONS BY BIQUADRATIC FUNCTIONS
Authors:   The Penza state university of architecture and construction, Bakushev S.V.
Published: August 2021

The present article considers the construction of differential equations of equilibrium of geometrically and physically nonlinear ideally elastoplastic in relation to shear deformations of continuous medium under conditions of one-dimensional plane deformation, when the diagrams of volumetric and shear deformation are approximated by biquadratic functions. The construction of physical dependencies is based on calculating the secant moduli of volumetric and shear deformation. When approximating the graphs of the volumetric and shear deformation diagrams using two segments of parabolas, the secant shear modulus in the first segment is a linear function of the intensity of shear deformations; the secant modulus of volumetric expansion-contraction is a linear function of the first invariant of the strain tensor. In the second section of the diagrams of both volumetric and shear deformation, the secant shear modulus is a fractional (rational) function of the shear strain intensity; the secant modulus of volumetric expansion-compression is a fractional (rational) function of the first invariant of the strain tensor. Based on the assumption of independence, generally speaking, from each other of the volumetric and shear deformation diagrams, five main cases of physical dependences are considered, depending on the relative position of the break points of the graphs of the diagrams volumetric and shear deformation. On the basis of received physical equations, differential equations of equilibrium in displacements for continuous medium are derived under conditions of plane one-dimensional deformation. Differential equations of equilibrium in displacements constructed in the present article can be applied in determining stress and strain state of geometrically and physically nonlinear ideally elastoplastic in relation to shear deformations of continuous medium under conditions of plane one-dimensional deformation, closing equations of physical relations for which, based on experimental data, are approximated by biquadratic functions.
THE METHOD OF FICTITIOUS REACTIONS IN THE MODELING OF THE CONTACT SURFACE ON THE EXAMPLE OF FLANGED CONNECTIONS.
Authors:   Volgograd state technical University, Kharlanov V.L. , Kharlanova S.V. ,   Volgograd state technical University
Published: August 2021

An iterative method for calculating flanged connections in the finite element formulation is proposed. The essence of the proposed method is to separate the contact problem into a separate localized process that depends only on the initial distribution of forces from the main load on the flange connection. In the initial matrix of stiffness of unrelated bodies, a binding matrix of contact with elements of high rigidity is added. The calculation is performed in two phases: the first phase determines the movement of the actual loads on the second, through a vector of dummy reactions, iterative specified voltage at the contact surfaces. The results obtained by the proposed method are compared with the experimental results and with the approximate calculation method.
El uso del foro virtual y su relación con el autoconcepto académico en estudiantes de Posgrado
Authors:   Universidad Privada Norbert Wiener, Merino Garcia Marcos Emilio
Published: August 2021

Los últimos avances tecnológicos han generado un gran impacto en el desarrollo de las sociedades en todo el mundo, a ello, sumado los últimos acontecimientos ya conocidos, referentes al aislamiento y distanciamiento social por causa de la pandemia del virus SARS: CoV-2 que origina la enfermedad Covid-19, y a las medidas de salud pública que incluyen el confinamiento social, han obligado a la población en general a hacer uso de las Tecnologías de la información y la comunicación (TIC), para migrar hacia lo virtual y conseguir que el desempeño de sus actividades cotidianas no se vean afectadas por los actuales cambios. El ámbito educativo no ha sido la excepción, y con la suspensión de las clases presenciales, los sistemas de enseñanza y aprendizaje han dado un giro hacia el uso de las nuevas herramientas virtuales, así como también de los recursos digitales, como el uso de los foros virtuales, para el logro de sus objetivos académicos y el acoplamiento de las nuevas tendencias en torno a la educación a distancia.
Two new species of plume moths (Lepidoptera: Pterophoridae) from Atacama Desert (Chile)
Authors: Ustjuzhanin Petr , Kovtunovich Vasily , Pototski Aleksander , Nupponen Kari , Haverinen Risto , Streltzov Alexander
Published: August 2021

Two new species of plume moths from Atacama Desert, Chile, are described: Lioptilodes karinupponeni Ustjuzhanin, Kovtunovich & Pototski sp. nov. and Hellinsia haverineni Ustjuzhanin, Kovtunovich & Pototski sp. nov.
Psychological intervention in breast cancer pathology
Authors:   Faculty of Psychology and Educational Sciences, University of Bucharest, Romania, IORDĂCHESCU Diana-Antonia , PAICA Corina-Ioana ,   Faculty of Psychology and Educational Sciences, University of Bucharest, Romania, VLADISLAV Elena-Otilia ,   Faculty of Psychology and Educational Sciences, University of Bucharest, Romania, GICĂ Corina ,   “Filantropia” Clinical Hospital, Bucharest, Romania, BOTEZATU Radu ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PANAITESCU Anca Maria ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, CIOBANU Anca Marina ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PELTECU Gheorghe ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, GICĂ Nicolae ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Breast cancer is an extremely important public health issue for doctors. Health professionals draw attention to the importance of early detection of the disease, so that treatment becomes effective. The experience of the disease can be extremely shocking and devastating for women. Studies show that women diagnosed with breast cancer experienced prolonged emotional difficulties during the year following diagnosis. This article proposes a review of some important methods and techniques used in the psychotherapy of breast cancer patients, such as: art therapy, cognitive-behavioral stress management, mindfulness-based stress reduction, acceptance and commitment therapy, compassion focused therapy and experiential psychotherapy. This paper is a review based on information from the literature. The analysis was limited to articles and guides in English published between January 1 and June 1 2021, on PubMed, ScienceDirect and Google Scholar, using the following keywords: breast cancer, women, depression, distress, anxiety, mental health, psychotherapy, interventions, treatment. In this review we discuss the characteristics of breast cancer pathology, the psycho-emotional effects and the interventions needed to optimize quality of life. The psychotherapeutic approaches presented draw attention to the fact that psychological interventions are part of the complementary procedures to the treatment in the pathology of breast cancer and can improve the quality of life of pacients.
Hypertensive disorders in twin pregnancy
Authors:   “Filantropia” Clinical Hospital, Bucharest, Romania, DUMINICĂ-TURCU Ana , GICĂ Nicolae ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, CIMPOCA-RAPTIS Brînduşa Ana ,   “Filantropia” Clinical Hospital, Bucharest, Romania, CIOBANU Anca Marina ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, GICĂ Corina ,   “Filantropia” Clinical Hospital, Bucharest, Romania, BOTEZATU Radu ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PELTECU Gheorghe ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PANAITESCU Anca Maria ,   “Filantropia” Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Hypertensive disorders such as gestational hypertension, preeclampsia, eclampsia and HELLP syndrome are one of the most common pregnancy-associated entities that imply substantial maternal-fetal mortality and morbidity. When hypertensive disorders are associated with a multiple pregnancy, the outset is established sooner, with a rapid evolution and a more severe development. Although, the pathophysiology of hypertensive disorders is not fully understood, there are several risk factors that could be identified. A multiple pregnancy implies additional risks due to specific features: larger or multiple placentas, failure of the uteroplacental unit to uphold the natural development of multiple fetuses or elevated risk of abnormal placental site. Hypertensive disorders include complications that are common for both single and multiple pregnancies, complications such as kidney failure, liver dysfunction, neurological or hematological malfunction, among others. Maternal features, including mean arterial blood pressure, uterine artery pulsatility index and blood levels of PAPP-A and/or PlGF could be determined at an early age and used as screening methods.
HISTORICAL ASPECTS IN CENTRAL VESTIBULAR SYNDROME
Authors:   “Grigore Alexandrescu” Emergency Clinical Hospital for Children, Bucharest, Toader Miorita , Oprea Alina ,   “Grigore Alexandrescu” Emergency Clinical Hospital for Children, Bucharest, Draghici Mircea ,   Dentirad Hospital, Ploiesti, Osman Andrei ,   Regional Clinical Hospital, Craiova, Mogoanta Carmen ,   University of Medicine and Pharmacy, Craiova
Published: August 2021

Central vestibular syndromes raise many challenges through their differential diagnosis. Throughout the last two centuries the advent of medical technologies provided new insights into the underlying pathophysiological mechanisms. The first studies date back in 1824 when Flourens researched the physiology of the labyrinth. As a result of the incomplete knowledge on the anatomy of central vestibular structures, the cerebellum was initially incriminated for the vestibular syndromes. First similarities between labyrinth related symptoms and cerebellum disorders were investigated by Babinski in 1913. Eventually, vestibular signs were also attributed to cerebellar peduncles lesions. The article outlines a chronological systematization of the steps taken throughout time in establishing the features of central vestibular syndrome.
INFLUENCE OF PRE-SYMPTOMATIC AND SYMPTOMATIC STAGES OF PARKINSON’S DISEASE AND ITS TREATMENT UPON CHANGES OF VARIABILITY OF CARDIAC RHYTHM
Authors:   Bakulev Scientific Center of Cardiovascular Surgery, Moscow, Mamalyga M.L. , Mamalyga L.M. ,   Department of Anatomy and Human and Animal Physiology of Institute Biology and Chemistry of Moscow State University of Education, Moscow
Published: August 2021

The aim of the study was to determine the influence of pre-symptomatic and symptomatic stages of Parkinson’s disease and its treatment on the cardiac disorders in C57BL/6 mice. Materials and methods. Investigations were carried out on C57BL/6 male mice. Degeneration of dopaminergic neurons were created by the neurotoxin. In freely moving animals in online regime a 24-hour ECG recording using wireless telemetry system ML880B106 was conducted. After completing studies animals was injected L-dopa (a precursor of dopamine synthesis). All the animals underwent repeated study of HRV. Results. The disbalance of autonomic heart regulation develops already in the pre-symptomatic stage of Parkinson’s disease. The early symptomatic stage is accompanied by the aggravation of heart dysfunction due to the shift of the autonomic balance towards the increase of sympathetic and decrease of parasympathic effect on the heart. Coronary disorders concomitant to Parkinson’s disease increase a risk of life threatening arrhythmia and sudden death syndrome not only in the early symptomatic stage but also in the pre-symptomatic stage. Conclusions. L-dopa effectively restores the structure of heart rate and prevents the risk of life threatening arrhythmia only in the pre-symptomatic stage of disease.
AQP-4 AND ITS ROLE IN MAINTAINING THE HYDRIC BALANCE IN THE BRAIN
Authors:   Department of Physiopathology II, The Experimental Medicine and Fundamental Research  Laboratory, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Popescu Elena-Silvia , Pirici Daniel ,   Department of Research Methodology, University of Medicine and Pharmacy of Craiova, Romania, Zurac Sabina Andrada ,   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, Bucharest, Ion Daniela Adriana ,   Department of Physiopathology II, The Experimental Medicine and Fundamental Research  Laboratory, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Aquaporins are a vast family of channel proteins whose main role is the bidirectional transport, depending on the osmotic gradient, of water across the lipid membranes, which have low permeability for this solvent. The aquaporins are also involved in the lipid metabolism, the cell proliferation and migration processes, the transport of glycerol, neuroexcitation and epithelial fluids secretion, having numerous roles such as ensuring the water transport in the central nervous system, the production of CSF, aqueous humor and saliva, epithelial hydration, urine concentration and nervous impulse transmission. Up to now, in mammals there have been identified 13 types of aquaporins, each of them annotated from 0 to 12 (Aqp 0 – Aqp 12). Of these, aquaporin-4 (AQP-4) – located in the astroglia - is the most abundant aquaporin in the brain. Although this type of aquaporin is also present inside the brain parenchyma, especially in the astroglial processes lining the neuronal synapses, AQP-4 is mainly located in the astroglial end-feet adjacent to the ependymocyes or endothelial cells, where its main role is to ensure the bidirectional transport of water between the astroglia and the cerebrospinal fluid (CSF) or blood vessels. The presence of AQP-4 on the surface of astroglial processes promotes, in the initial stages of ischemia, the formation of the cytotoxic oedema, but has a protective role against vasogenic oedema. This review aims to describe the roles of AQP-4, and especially the role that this protein has in maintaining the hydric balance in the brain.
ANTIOXIDANT EFFECT OF FLAVONOIDS IN NEURODEGENERATIVE DISEASES
Authors:   Department of Pathophysiology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Bulboaca Adriana E. , Bolboaca Sorana S. ,   Department of Medical Informatics and Biostatistica, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Stanescu Ioana C. ,   Department of Neurology and Pediatric Neurology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Sfrangeu Carmen A. ,   Department of Pathophysiology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Bulboaca Angelo C. ,   Department of Neurology and Pediatric Neurology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca
Published: August 2021

The investigation of the mechanisms that leads to neuronal apoptosis is under investigation all over the world. The enhancement of oxidative stress in brain neurons is one of the most important pathophysiological mechanism associated with neurodegeneration. The antioxidant effect of flavonoids can be one important mechanism for modulation of neuronal apoptosis in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. In addition to their influence on the cerebral blood flow, flavonoids interact with signalization cascades that lead to the inhibition of neuronal death by oxidative stress apoptosis and thus promote neuronal survival and synaptic plasticity. Acting on the intracellular antioxidant mechanisms the flavonoids can become a balance regulator for production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Addition of antioxidant effect of flavonoids to dietary components can constitute an adjuvant therapy for delaying the neurodegenerative processes. The aim of this paper was to review the antioxidant effects of flavonoids in Alzheimer’s and Parkinson’s diseases.
DOUBLE SERO-NEGATIVE MYASTHENIA GRAVIS ASSOCIATED WITH THYMIC HYPERPLASIA AND AUTOIMMUNE THYROIDITIS IN A YOUNG PATIENT
Authors:   Department of Neurology, Emergency Clinical Hospital, Sibiu, Catana Maria-Gabriela , Cuibus Liliana Cristina ,   Department of Neurology, Emergency Clinical Hospital, Sibiu, Dan Andreea ,   Department of Neurology, Emergency Clinical Hospital, Sibiu, Roman-Filip Corina ,   Department of Neurology, Emergency Clinical Hospital, Sibiu,   “Lucian Blaga” Unversity, Sibiu
Published: August 2021

Myasthenia gravis is an autoimmune disorder affecting the postsynaptic neuromuscular junction. Clinically it evolves with fluctuating muscle weakness. In 13-22% of the reported cases, another autoimmune disorder is associated. We report the case of a 21 years old woman presenting at 4 months after delivrence, global muscle weakness, dysphonia, dysartria and dysphagia. Biological tests reveal: AchR antibodies and anti-MUSK antibodies – negative, TSH 4,68 μIU/ml (normal range: 0,4-4 μIU/ml), FT4 0,785 ng/dl (normal range: 0,89-1,76 ng/dl), anti thyroglobulin antibodies 183,01 IU/mL (normal range: <4,11 IU/mL), Chest CT – thymic hyperplasia and EMG – decremental response at repetitive stimulation. It is established the diagnosis: myasthenia gravis Osserman stage IIb. After treatment with acetylcholine esterase inhibitors and corticosteroids the patient`s symptomathology has improved.
SURPRISING GENOTYPE EXPRESSED AS A COMMON LIMB-GIRDLE MUSCULAR DYSTROPHY
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Cozma Liviu , Barsevschi Maria ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Mitu Cristina ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Bastian Alexandra ,   Anatomical Pathology Laboratory, “Colentina” Clinical Hospital, Bucharest, Popescu Bogdan Ovidiu ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest,   Department of Molecular Medicine, “Victor Babes” National Institute of Pathology, Bucharest
Published: August 2021

Limb-girdle muscular dystrophies (LGMDs) comprise a phenotypical spectrum of muscular dystrophies with a high degree of genotypical variability. We describe the case of a 56-year-old male with a history and clinical picture sugestive for LGMD with skeletal and cardiologic involvement. Histopathological examination shows a severe dystrophic picture and geneting testing revealed a unique never reported genotype association: a homozygous variant in the DES gene, associated with myofibrillar myopathy type 1 and LGMD2R, as well as a heterozygous variant in the CRYAB gene, associated with myofibrillar myopathy type 2, both of which could be responsible for the clinical picture.
CORRELATIONS BETWEEN ARTERIAL HYPERTENSION AND DIABETIC RETINOPATHY IN PATIENTS WITH TYPE II DIABETES
Authors:   Spitalul Universitar de Urgenţă, Bucureşti, Stana Daniela , Dascălu Ana Maria ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Ungureanu Emil ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Gherase Alexandra-Ioana ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Ardeleanu Ioana Sonia ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti,   Institutul Naţional pentru Sănătatea Mamei şi Copilului „Alessandrescu-Rusescu“, Bucureşti, Şerban Dragoş ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: August 2021

Diabetic retinopathy is a well-known complication of diabetes, a major cause of vision loss worldwide. Purpose. The present study investigates the correlation between hypertension and evolution of diabetic retinopathy in patients with type II diabetes. Materials and methods. We conducted a prospective study between June and December 2016, on 24 patients hospitalized in Ophthalmology Clinic, Emergency University Hospital Bucharest, with AO: diabetic retinopathy and arterial hypertension under medical treatment. Patients were evaluated at baseline, 2 months, 4 months and 6 months through comprehensive eye examination and measuring the value of blood pressure (BP). Comparative data were analyzed in patients with compensated hypertension (BP<150 mmHg) and subcompensated hypertension (BP> = 150 mmHg). Results. Of the 24 patients, 15 had values offset BP (group A) and 9 associated hypertension subcompensated (group B). In group A proportion of patients (at baseline) with diabetic retinopathy absent or nonproliferative was higher than patients in group B (47% vs. 22%, p = 0.052995019518117). Patients in group B had a higher tendency to record an evolution of diabetic retinopathy (in group B, 55.55% of patients had a progression, and in group A, only 26.66%). Conclusions. Incomplete therapeutic control of hypertension may affect the retinal microvasculature impacting the progression of diabetic retinopathy. Maintaining a strict control of systolic BP of permanent value bellow 140 mmHg should be part of the patient management guide of the diabetic patient in order to prevent ophthalmic complications with major risk of vision loss.
DIASTOLIC DYSFUNCTION – NEGATIVE PROGNOSTIC FACTOR IN PATIENTS WITH HEPATIC CIRRHOSIS
Authors:   Spitalul Clinic Judeţean de Urgenţă, Universitatea de Medicină şi Farmacie, Craiova, Mihailovici Alexandru , Buşe Maria ,   Spitalul Clinic Judeţean de Urgenţă, Craiova, Donoiu Ionuţ ,   Disciplina Cardiologie, Universitatea de Medicină şi Farmacie, Craiova, Istrătoaie Octavian ,   Disciplina Cardiologie, Universitatea de Medicină şi Farmacie, Craiova, Tudoraşcu Diana ,   Disciplina Medicină Internă, Universitatea de Medicină şi Farmacie, Craiova, Gheonea Dan Ionuţ ,   Disciplina Medicină Internă, Gastroenterologie, Universitatea de Medicină şi Farmacie, Craiova
Published: August 2021

Objectives. To evaluate the left ventricular diastolic function in patients with cirrhosis and to establish its relation to the degree of severity of liver disease as well as to biological markers of cardiac dysfunction. Methods. We included 72 patients diagnosed with liver cirrhosis in different degrees of disease progression. Cardiac parameters were evaluated by two-dimensional echocardiography and color Doppler. Results. In terms of diastolic echocardiographic function, 26 patients had normal diastolic function, 36 had grade 1 diastolic dysfunction, 8 had grade 2 dysfunction, and 2 patients had grade 3. Diastolic dysfunction was unrelated to age, gender and etiology of cirrhosis. Of all the echocardiographic parameters, left ventricular hypertrophy, right cavity dimensions, E wave deceleration time, left atrial volume were significantly higher in patients with diastolic dysfunction, correlated with the severity of cirrhosis. Significantly elevated NT-proBNP and TnI were seen among the patients with diastolic dysfunction. Conclusions. The present study shows that although diastolic dysfunction is common in cirrhosis, it is usually incipient and most often correlates with the severity of the liver disease (Child-Pugh class).
ORAL HEALTH IN CYSTIC FIBROSIS
Authors:   Departamentul Medicina mamei şi copilului, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, Anton-Păduraru Dana-Teodora , Marin Angelica Cristina ,   Spitalul de Urgenţă pentru copii „Sf. Maria“, Iaşi, Bizim Delia Andreia ,   Spitalul de Urgenţă pentru copii „Sf. Maria“, Iaşi, Drochioi Ana-Simona ,   Departamentul Medicina mamei şi copilului, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi
Published: August 2021

Cystic fibrosis (CF) is a very complex disease that raises significant health and social problems, being considered internationally an important public health problem. Known as a multi-organ disease that affects the following organs: salivary glands, lung, digestive tube, liver, pancreas, kidneys, reproductive organs, CF also has an impact on the oral health (structural abnormalities, abnormalities of the teeth eruption, damage to the enamel, accumulation of tartar, gingivitis, cavities, malocclusions, oropharyngeal candidiasis). The authors show the main implications of the disease at teeth level.
NUTRITIONAL AND BEHAVIOURAL PECULIARITIES OF THE POPULATION IN THE GENESIS OF DIGESTIVE DISEASES
Authors:   Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ Chişinău, Republica Moldova, Sabău David , Friptuleac Grigore ,   Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ Chişinău, Republica Moldova
Published: August 2021

Background. Digestive diseases, the third leading cause of death in Romania (4.9% of total deaths in 2010), are responsible for the annual loss of about 77 persons/100,000 population in 2009-2010, increasing compared to 2005. The large share these diseases have in pathology, high potential disabling of some of them, their interactions with environmental factors and food require their knowledge in early stages, treatment and prevention of complications. Aims. Aim of this study are to estimate the particularities of nutrition and the health of people with diseases of the digestive system, highlighting behavioral risk factors and preventive measures development in Cluj County. Methods. There were established two study groups, each made up of 255 people, including 1st lot that includes people taking one of the Cluj County digestive diseases known, and the 2nd lot that is being made of the population compared to the same county that have not been diagnosed diseases of the digestive tract. Results. In the study there were identified and prioritized key digestive disorders diagnosed in the group of subjects who are established in a particular period in Gastroenterology Clinic of Cluj Napoca. They determine relations between morbidity by diseases of the digestive and behavioral risk factors and they were developing preventive measures determining the impact of behavioral risk factors in the onset and development of diseases of the gastrointestinal tract. Conclusions. 1. In the conducted study found that digestive pathology had a wide representation among the investigated subjects, including all segments of the digestive tract. 2. At all digestive pathologies studied could not detect a single factor, each being able pathology could be assigned several factors (food, behavioral, environmental etc.). 3. Food factor can be considered as the predominant factor in the onset, maintenance or aggravation of digestive pathologies studied. 4. In the conducted study it was established as risk factors (along with the food) also smoking, alcohol consumption, a family history and even some vitamin deficiencies. 5. Extended studied digestive pathology is found distributed in proportions relative to the geographic areas studied area of Cluj County. On the regions, distribution percentages are so close that differences are considered unsignificant (North East – 22%, 23% – Northwest, Southwest - 29% and Southeast - 26%).
ENDOSCOPIC TREATMENT FOR UPPER GI BLEEDING. REVALIDATION OF FORREST CLASSIFICATION
Authors:   University Hospital, Bucharest, EL-KHATIB Ahed , Alius Catalin ,   University Hospital, Bucharest, Serban Dragos ,   University Hospital, Bucharest
Published: August 2021

Despite rapid advances in endoscopic treatments and the development of updated and evidence based guidelines, morbidity and mortality in upper gastrointestinal bleeding (UGIB) remains high. A recent study conducted in a tertiary centre on 80 consecutive patients with UGIB demonstrated that lower doses of Adrenaline 1:10000 and diathermy were superior to high doses of Adrenaline injections only, but failed to reduce the mortality rates, despite a reduction in the need for transfusion, second look and surgical interventions. We believe that comorbid conditions have greater influence on survival rates in patients with UGIB than the achievement of immediate haemostasis and we attribute a paramount importance to rapid and correct resuscitation of the bleeding patient prior to any endoscopic assessment.
CORRELATIONS OF THE USUAL BLOOD PARAMETERS WITH THE INCIDENCE OF DENTAL CARIES IN A GROUP OF PATIENTS WITH CHRONIC ALCOHOLIC HEPATITIS
Authors:   Disciplina Fiziologie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Bădiţa Daniela G. , Stănescu Iulia I. ,   Disciplina Fiziologie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Balcangiu-Stroescu Andra E. ,   Disciplina Fiziologie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Calenic Bogdan ,   Disciplina Biochimie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Tănăsescu Maria-Daniela ,   Disciplina Medicină Internă I şi Nefrologie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti,   Clinica de Nefrologie, Spitalul Universitar de Urgenţă, Bucureşti, Răducu Laura ,   Clinica de chirurgie plastică şi microchirurgie reconstructivă, Spitalul Clinic de Urgenţă „Prof. Dr. Agrippa Ionescu“, Bucureşti, Nimigean Victor ,   Disciplina Anatomie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Piperea-Şianu Dan ,   Disciplina Fiziologie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: August 2021

Objectives. To investigate the correlations between the frequency of dental caries, assessed as cariogenic index, and a series of blood parameters in patients diagnosed with chronic hepatitis of alcoholic etiology. Materials and method. The study was conducted on a total of 25 patients diagnosed with chronic hepatitis of alcoholic etiology. The following blood parameters were determined: blood count (erythrocyte count, total hemoglobin, hematocrit, mean red blood cell volume, mean red blood cell hemoglobin, mean erythrocyte hemoglobin concentration), platelet count, white blood cell count (leukocyte count, neutrophils ratio, lymphocytes ratio, monocytes ratio, eosinophils ratio, basophils ratio) and glucose, urea and creatinine concentrations. Results. The mean values were: cariogenic index 1.8±0.96, erythrocytes 4.66±0.51x106/mm3, total hemoglobin concentration 14.67±1.26 g/dL, hematocrit 44.45±3.75%, mean erythrocyte volume 95.6±6.03 fL, mean erythrocyte hemoglobin 31.6±1.86 pg, mean erythrocyte hemoglobin concentration 33.01±1.02 g/dL, platelet count 2.7±0.61x105/mm3, leukocytes 8,812±2,065.66/mm3, neutrophils ratio 63.32±8.75%, lymphocytes ratio 26.32±8.48 %, monocytes ratio 7.99±2.02 %, eosinophils ratio 1.87±1.6%, basophils ratio 0.5±0.31%, glycemia 91.52±8.38 mg/dL, urea concentration 32.12±8.44 mg/dL and creatinine 0.92±0.19 mg/dL. Conclusions. We have been able to establish statistically significant correlations between the cariogenic index and total hemoglobin, hematocrit, mean erythrocyte hemoglobin concentration and glycemia.
PREVALENCE OF COLONIC POLYPOIDAL COLONIC FORMATIONS IN A REVERSE ENDOSCOPIC STUDY. THE EXPERIENCE OF A SINGLE CLINICAL CENTER
Authors:   Spitalul Clinic CF1 Witting, Bucureşti, Alexandru Septimiu ,   Şcoala Doctorală Domeniul Medicină, IOSUD Universitatea „Titu Maiorescu“, Bucureşti, Ungureanu Florin Dan ,   Spitalul Clinic CF1 Witting, Bucureşti,   Şcoala Doctorală Domeniul Medicină, IOSUD Universitatea „Titu Maiorescu“, Bucureşti,   Facultatea de Medicină, Universitatea „Titu Maiorescu“, Bucureşti, Moldovan Cosmin ,   Spitalul Clinic CF1 Witting, Bucureşti,   Şcoala Doctorală Domeniul Medicină, IOSUD Universitatea „Titu Maiorescu“, Bucureşti,   Facultatea de Medicină, Universitatea „Titu Maiorescu“, Bucureşti
Published: August 2021

Objectives. The present study has highlighted the number of tumoral protruzive formations found overall, in a sample of a population that is targeted at a hospital for a varied symptomatology study with patients admitted in the hospital, and not on a lot presumed healthy (without clinical symptoms), as in the case of screening. Material and method. The research was conducted as observational longitudinal study, on a 2000 investigations performed on patients hospitalised in the Witting Clinical Hospital between January 2009 and January 2017. Results. A number of patients out of 2000 colonoscopies were found with 594 tumor formations; of these, 148 have been identified (24.9%) cases of colon cancer 446 75%) and formations (of type polypoid. Conclusions. The study was able to identify more parameters with statistical significance, such as the number of colonoscopies which has varied in relation to the sex of the subjects investigated, the age of patients with colorectal cancer on age levels. The study also show that both sexes cancer occurs at a higher age than the occurrence of polyps, which suggests that early detection of polyps and resection can stop their malignization. Distribution of poliypectomies in relation to the type and degree of polyp malignization varied not statistically significant for both unique and multiple polyps, the maximum frequency being recorded at low dysplasia. Note that in the case of singular polyp, frequency of polyps with high-grade dysplasia was double compared to that recorded for multiple polyps (9% vs. 4%).
ABDOMINAL OR VAGINAL ROUTE FOR GENITAL PROLAPSE TREATMENT. ARGUMENTS PRO AND AGAINST THE USE OF MESH
Authors:   Department of Obstetrics and Gynecology. Breast Center. “Fichtelgebirge” Klinikum. Marktredwitz, Bayern, Germany, Ionescu Olivia , Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology. Breast Center. “Fichtelgebirge” Klinikum. Marktredwitz, Bayern, Germany,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Saba Nahedd ,   Department of Obstetrics and Gynecology, “Polizu” Clinical Hospital, Bucharest,   “Alessandrescu-Rusescu” National Institute of Mother and Child Health, Bucharest, Banceanu Gabriel ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest,   Department of Obstetrics and Gynecology, “Polizu” Clinical Hospital, Bucharest,   “Alessandrescu-Rusescu” National Institute of Mother and Child Health, Bucharest
Published: August 2021

Perhaps one of the most challenging part of surgical treatment of genital prolapse is the surgical planning and its associated aspects such as the approach- vaginal, abdominal or laparoscopi/robotic, the concomitant performance of a hysterectomy and other prophylactic measures – salpingo-oophorectomy or prophylactic salpingectomy and, not least, the benefits of using a mesh for reestablishing the anatomical position of the prolapsed organs. Certainly, every decision on surgery should be individualized on every women taking into account the particularity of the pelvic pathologic – the grade of the genital prolapse according to the Pelvic Organ Prolapse Quantitation (POP-Q) system, the type of prolapse compartment and whether isolated or associated with other types of prolapse-, the risk of intra- and perioperative complications, mesh-associated risk as well as the risk of recurrence, the impact of the surgical treatment on the sexual activity of the women and certainly also the women’s expectations from the surgical treatment. In this review we aimed to present the general aspects which must be considered when it comes to the decision on a non-conservative treatment of the genital prolapse with regard to the advantages and disadvantages of the abdominal, vaginal and laparoscopic route and to the benefits and limits of using a mesh.
PROTECTIVE FACTORS AGAINST DEPRESSION IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE WITH CRITICAL LIMB ISCHEMIA
Authors:   Department of Medical Psychology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Diaconescu Liliana Veronica , Diaconescu Ion ,   Department of Vascular Surgery, “Prof. Dr. C.C. Iliescu” Emergency Institute for Cardiovascular Diseases, Bucharest
Published: August 2021

Introduction. The aim of the study was to assess the extent to which psychosocial factors (social support and coping strategies) may have a protective role against depression in patients with peripheral arterial disease (PAD). Methods. The design of the study was transversal and included 37 patients with PAD with critical ischemia (32 men, 5 women, mean age = 62.41). They were administered Center for Epidemiologic Studies Depression Scale, Duke-UNC Functional Social Support Questionnaire and COPE inventory. Results. Depressive symptoms were found at 28.6% of the patients. There were low scores of perceived social support at 32.4% of the patients. Depression correlated (p<.001) positively with mental disengagement (r=.791), denial (r=.672), behavioral disengagement (r=.760), restraint (r=.075) and negatively with social support (r= -.879) and positive reinterpretation (r=-.844), active coping (r=-.776), use of emotional support (r=-.624). Discussion. PAD patients experience depression. Is highlighted the buffer role of social support and of active coping strategies in facing a chronic disease. Conclusions. Recognition and evaluation for depression in patients with PAD followed by identifying psychosocial interventions may be useful in improving outcomes of these patients.
THE CORRELATION BETWEEN SERUM VITAMIN D LEVELS AND CUTANEOUS INVOLVEMENT IN METABOLIC SYNDROME
Authors:   Carol Davila University of Medicine and Pharmacy, Bucharest, Stănescu Ana Maria Alexandra , Grăjdeanu Ioana Veronica ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Bejan Gabriel Cristian ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Iancu Mihaela Adela ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Appiah Ekua Asafoaba ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Peagu Răzvan ,   Carol Davila University of Medicine and Pharmacy, Bucharest,   University Emergency Hospital Bucharest, Matei Dumitru ,   Carol Davila University of Medicine and Pharmacy, Bucharest,   Alessandrescu- Rusescu" INSMC, Bucharest
Published: August 2021

Aims. The rising global trend of metabolic syndrome cases has increased the problems associated with decreasing serum vitamin D levels and the likelihood of cutaneous involvement. This research was aimed at determining the prevalence of metabolic syndrome, the distribution of its components and correlation the between serum vitamin D levels and possible skin involvement in the patients. Materials and methods. The study of Romanian citizens was conducted between 2010 and 2017, involved mainly urban dwellers with a median age of 18. The parameters measured included physical examination and fasting blood tests. The criteria of the International Diabetes Federation (IDF) was used for the metabolic syndrome diagnosis. The serum 25 (OH) D levels were based on the laboratory reference values and the severity of psoriasis was calculated according to the BSA score. Results. The total number of participants in the study was 634, of which 36% were diagnosed with metabolic syndrome, with a 59% prevalence of females. The distribution of the components of the metabolic syndrome was: 100% increased waist circumference (mandatory component for diagnosis), hyperglycaemia 53.7%, low HDL cholesterol 44.9%, triglyceride increase 26.4%, high blood pressure 21.6%. Low serum vitamin D levels were found at 54.6%. Psoriasis showed 46.2% of all those with metabolic syndrome. Conclusion. After thorough analysis of the data, it can be concluded that there is a relationship between the presence of metabolic syndrome and serum vitamin D, the latter being mostly low in the studied group. The more the components of metabolic syndrome are present, the lower the vitamin D serum level. The presence of psoriasis can aggravate metabolic syndrome components and vitamin D serum decline. Further studies can determine whether serum vitamin D normalization can bring improvements in metabolic syndrome components.
Iraqi License Plate Detection and Segmentation based on Deep Learning
Authors: Abbass Ghida , Marhoon Ali
Published: August 2021

Nowadays, the trend has become to utilize Artificial Intelligence techniques to replace the human's mind in problem solving. Vehicle License Plate Recognition (VLPR) is one of these problems in which the computer outperforms the human being in terms of processing speed and accuracy of results. The emergence of deep learning techniques enhances and simplifies this task. This work emphasis on detecting the Iraqi License Plates based on SSD Deep Learning Algorithm. Then Segmenting the plate using horizontal and vertical shredding. Finally, the K-Nearest Neighbors (KNN) algorithm utilized to specify the type of car. The proposed system evaluated by using a group of 500 different Iraqi Vehicles. The successful results show that 98% regarding the plate detection, and 96% for segmenting operation.
Spor Kulüplerine Devam Eden Zihinsel Engelli Bireylere Sahip Ebeveynlerin Spordan ve Spor Kulüplerinden Beklentilerinin Karşılanma Düzeyleri
Authors: ILKIM Mehmet , ÖZOĞLU Fatma , KALAYCI Metin Can , PAKTAŞ Yakup , KESKİN Muzaffer Toprak
Published: August 2021

Araştırmanın amacı spor kulüplerine devam eden zihinsel engelli bireylere sahip ebeveynlerin spordan ve spor kulüplerinden beklentilerinin karşılanma düzeylerini çeşitli değişkenler açısından incelemektir. Araştırma tarama modelinde olup, uygun örnekleme yöntemi kullanılmıştır. Araştırmanın evrenini Malatya’da spor kulüplerine devam eden zihinsel engelli bireylere sahip ebeveynler oluştururken, örneklemini ise spor kulüplerine devam eden zihinsel engelli bireye sahip 62 ebeveyn oluşturmuştur. Veri toplama aracı olarak araştırmacıların hazırladığı Demografik Değişkenler Bilgi Formu ve Bingöl (2010) tarafından geliştirilen Spor Merkezlerinden Beklentilerin Karşılanma Düzeyi Ölçeği” kullanılmıştır. Verilerin normallik dağılımı Kolmogorov-Smirnov Normallik Testi ile, bağımsız gruplar arası farklılıklar bağımsız örneklem t-testi ve tek yönlü varyans analizi ile tespit edilmiştir. Değerlendirmede; ebeveynlerin Spor Merkezlerinden Beklentilerin Karşılanma Düzeyi Ölçeği’nden elde ettikleri ölçek toplam madde puan ortalama değerlerine göre %80±3 oranında beklentilerinin karşılandığı, yaş, cinsiyet, eğitim durumu, sahip olunan zihinsel engelli bireylerin ne kadar süredir spor kulüplerine devam etme durumu ve spor kulüplerinde her seansta ne kadar süre geçirdikleri durumu değişkenlerine göre ise spor merkezlerinden beklentilerin karşılanma düzeyi değerlerinin anlamlı bir farklılık göstermediği belirlenmiştir. Sonuç olarak; Malatya kentindeki spor kulüplerine devam eden zihinsel engelli bireylere sahip ebeveynlerin spordan ve spor kulüplerinden beklentilerinin yüksek oranda karşılandığı söylenebilir.