bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Natural Scenes to Enhance our Understanding of the Cerebral Cortex's Role in Visual Search
Authors: Segraves Mark A.
Published: May 2023

Using natural scenes is an approach to studying the visual and eye movement systems approximating how these systems function in everyday life. This review examines the results from behavioral and neurophysiological studies using natural scene viewing in humans and monkeys. The use of natural scenes for the study of cerebral cortical activity is relatively new and presents challenges for data analysis. Methods and results from the use of natural scenes for the study of the visual and eye movement cortex are presented, with emphasis on new insights that this method provides enhancing what is known about these cortical regions from the use of conventional methods.
Fluorenone Decorated RGO Based Electrochemical Sensor for Rapid Detection of Chlorpyrifos in Vegetable and Soil Samples
Authors: Neha  , Kaur Ranjeet , Jyoti  , Rana Shweta , Kaur Navneet
Published: May 2023

A novel synthetically accessible electrochemical sensor has been developed for the detection of chlorpyrifos (CPS) at a very minimal level by utilizing a glassy carbon electrode (GCE) modified with RGO functionalized fluorenone derivative (RGO-NS). The structural and morphological aspects of the derived composite were assessed by FTIR, XRD, FESEM, DFT with in-depth electrochemical analysis. The fluorenone appended with distinct functionalities has supported the reversible redox reactions of CPS, thus, boosting the specificity of the sensor. The design of the electrochemical sensors involved functionalization of RGO possessing high adsorption capacity, which has further amplified the electrochemical sensitivity. The sensing response has been credited to the reduction associated with hydrogen ion which on addition of CPS gets quenched due to catalytic reaction between the two. The synergy has resulted in the low detection limit of 8.89 ng ml−1 for CPS along with reliable detection of CPS in soil samples without spiking. The framework has the excellent future prospects in the practical management of pernicious pesticides usually employed in agricultral fields and their residues on food products posing a serious danger to human health.
Water-Soluble Binders That Improve Electrochemical Sodium-Ion Storage Properties in a NaTi2(PO4)3 Anode
Authors: Zhang Yan , Grant Alex , Carroll Aoife , Gulzar Umair , Ferguson Matthew , Roy Ahin , Nicolosi Valeria , O’Dwyer Colm
Published: May 2023

Water-soluble binders are demonstrated to provide significantly better capacity, cycle life stability and rate response for NASICON-type NaTi2(PO4)3 Na-ion battery anodes during reversible sodiation compared to electrodes made using polyvinylidene difluoride-containing slurries. The role of carboxymethyl cellulose (CMC) binders on the physical structure and chemical interfacial reactions with sodium-poor NaTi2(PO4)3 are uncovered using electron microscopy and spectroscopy data and we show that a more stable NASICON NaTi2(PO4)3 structure is found from the desodiation process from compensation of sodium deficiencies in the NaTi2(PO4)3 by extra sodium from the CMC binder. When the binder comprises CMC and a styrene butadiene rubber (SBR) additive, the electrode delivers significantly better voltammetric and galvanostatic electrochemical response with a specific capacity of ∼120 mAh g−1 with capacity retention of 90.5% for 500 cycles at 0.2 C (1 C = 133 mAh g−1), and ∼54 mAh g−1 at 20 C. The durability of the electrode during cycling and the stability of the redox processes ensures a higher capacity, longer cycle life electrode which is important for sustainable materials development for Na-ion technologies.
S-Doped Graphene Oxide/N-Doped Graphene Oxide/PANI: A Triple Composite for High-Performance Supercapacitor Applications
Authors: Yasa Sezgin , Kumbasi Okyay , Arvas Melih Besir , Gencten Metin , Sahin Mutlu , Sahin Yucel
Published: May 2023

In this study, nitrogen doped graphene oxide(N-GO) and sulfur doped graphene oxide(S-GO) were produced in one step, and two of these prepared materials were converted into composite form with polyaniline(PANI). For the first time in the literature, triple composite electrode materials with two heteroatom doped graphene oxides and PANI were prepared for supercapacitors. In this context, heteroatom doped graphene oxides and PANI were characterized using spectroscopic and microscopic methods. With the ternary composites formed, anode and cathode electrode materials for coin cell type supercapacitors in asymmetrical form were characterized by electrochemical methods. The capacitive behavior of the prepared supercapacitors was investigated by cyclic voltammetry(CV) and electrochemical impedance spectroscopy(EIS) method. The change of capacitive behavior according to the number of cycles was determined by cyclic charge-discharge tests. With the electrode materials obtained with heteroatom doped graphene oxides/PANI composites, it reached the highest areal capacitance value of 79.7 mF.cm−2 at 10 mV.s−1 scan rate. The coin cell type asymmetric supercapacitors retained more than 100% of their initial specific capacitance at the end of the 1500 cycle.
Visual information following object grasp supports digit position variability and swift anticipatory force control
Authors: Bland Joshua T. , Davare Marco , Marneweck Michelle
Published: May 2023

Humans excel in dexterous object manipulation by precisely coordinating grasp points and fingertip forces, highlighted in scenarios requiring countering object torques in advance, e.g., lifting a teacup without spilling will demand a unique digit force pattern based on the grip configuration at lift onset. Here, we show that visual information following grasp contact, a critical and functionally relevant time point, supports digit position variability and swift anticipatory force control to achieve a dexterous motor goal.
Investigation of Gas Release from Recycled Plastic Shopping Bags during Melting at Low Temperatures
Authors: Eberhard Friederike Susette , Bowtell Leslie , Lenske Brian , Islam Md Mainul
Published: May 2023

Recycling plastic is an excellent way to reduce the environmental impact of its production and use. In a circular economy, recycling of recycled plastic is necessary. Most plastic bags are made of thermoplastic, like high-density polyethylene (HDPE) with a melting point of 130°C, and low-density polyethylene (LDPE). In contrast, recycled plastic bags are made up of many different unknown substances. In this study, the melting of used plastic bags containing 80% unknown recycled material was investigated. FTIR analysis showed that the bags consisted mainly of HDPE. The bags were melted at 160°C, 200°C, and 250°C for 30 min. GC-FID and HP-SPME GCMS analyses showed that the bags released flammable gases (methane, ethylene, and alkane/alkene hydrocarbons) but little acetylene. Aromatic and aliphatic hydrocarbons eluded from the bags at 10% of the gas volume at 250°C. Long-chain alkanes, mostly hexadecane, were the dominant compound, amounting to 28% at 160°C and increasing to 43% at 250°C. On the other hand, alkenes decreased with a rising temperature (23% at 160°C to 3% at 250°C), as they were transformed into alkanes. Methylated compounds, for example, methylated alkanes at 10%, were present at all temperatures. Methane and methylated compounds are released from plastic and contamination of the bags with organic matter. The bags released small amounts of toxic phthalates. The results show that melting recycled plastic bags for remoulding is promising if safety precautions that ensure sufficient ventilation are utilised.
Antidiabetic Medication Utilisation before and during Pregnancy in Switzerland between 2012 and 2019: An Administrative Claim Database from the MAMA Cohort
Authors: Gerbier Eva , Favre Guillaume , Maisonneuve Emeline , Ceulemans Michael , Winterfeld Ursula , Dao Kim , Schmid Christian P. R. , Jenkinson Stephen P. , Niznik Bartlomiej , Baud David , Spoendlin Julia , Panchaud Alice
Published: May 2023

Background. The incidence of diabetes mellitus (both pregestational and gestational) is increasing worldwide, and hyperglycemia during pregnancy is associated with adverse pregnancy outcomes. Evidence on the safety and efficacy of metformin during pregnancy has accumulated resulting in an increase in its prescription in many reports. Aims. We aimed to determine the prevalence of antidiabetic drug use (insulins and blood glucose-lowering drugs) before and during pregnancy in Switzerland and the changes therein during pregnancy and over time. Methods. We conducted a descriptive study using Swiss health insurance claims (2012-2019). We established the MAMA cohort by identifying deliveries and estimating the last menstrual period. We identified claims for any antidiabetic medication (ADM), insulins, blood glucose-lowering drugs, and individual substances within each class. We defined three groups of pattern use based on timing of dispensation: (1) dispensation of at least one ADM in the prepregnancy period and in or after trimester 2 (T2) (pregestational diabetes); (2) dispensation for the first time in or after T2 (GDM); and (3) dispensation in the prepregnancy period and no dispensation in or after T2 (discontinuers). Within the pregestational diabetes group, we further defined continuers (dispensation for the same group of ADM) and switchers (different ADM group dispensed in the prepregnancy period and in or after T2). Results. MAMA included 104,098 deliveries with a mean maternal age at delivery of 31.7. Antidiabetic dispensations among pregnancies with pregestational and gestational diabetes increased over time. Insulin was the most dispensed medication for both diseases. Between 2017 and 2019, less than 10% of pregnancies treated for pregestational diabetes continued metformin rather than switching to insulin. Metformin was offered to less than 2% of pregnancies to treat gestational diabetes (2017-2019). Conclusion. Despite its position in the guidelines and the attractive alternative that metformin represents to patients who may encounter barriers with insulin therapy, there was reluctance to prescribe it.
Optimization Technique for Renewable Energy Storage Systems for Power Quality Analysis with Connected Grid
Authors: Senthil Kumar R. , Acharyulu B. V. S. , Dhal P. K. , Adlakha Richa , Kumar Sonu , Saravanan C. , Shah Krishna Bikram
Published: May 2023

Power quality is the main problem with the power system network. Poor electricity quality may cause disruptions and financial challenges for consumers. Additionally, it could cause electronic gadgets to overheat, be damaged, or operate inadvertently. Transformers and other components of the power distribution system may also overheat and experience core saturation. This study investigates potential problems with the quality of the electricity in a photovoltaic linked power system. This paper suggests a new optimization method for day-ahead trading and control in DC microgrid power management (MG). The goal of the multiobjective optimization dispatch (MOOD) problem is to lower overall operational costs as well as the costs associated with power loss in efficient conservation systems and exhaust emission quantities such as nitrogen oxides, sulphur dioxide, and carbon dioxide. Using the weighted sum approach, the multiobjective optimization problem is reduced to a single optimization problem. The analytical hierarchy process (AHP) method is then used to calculate the weight coefficients while accounting for each objective function’s preferences. Power balancing, high levels of renewable energy penetration, the most effective scheduling of battery charging and discharging, control of load curtailment, and the technical limitations of the system are all taken into account when evaluating the system’s performance in both grid-connected and standalone operation modes. The ant lion optimizer (ALO) technique is taken into account to tackle MOOD, comparing the effectiveness of the proposed method to other well-known heuristic optimization techniques. The simulation’s results demonstrate how effectively the proposed strategy can address the coordinated control and optimization dispatch difficulties. They also found that operating the MG system economically in grid-connected mode can save overall costs by roughly 4.70% compared to doing it in independent mode.
Four-Channels High-Resolution Frequency Counter for QCM Sensor Array Using Generic FPGA XC6SLX9 Board
Authors: Triqadafi Adin O. , Zafirah Tyas N. , Dharmawan Hari A. , Sakti Setyawan P.
Published: May 2023

A frequency counter is essential for resonance-based sensors like quartz crystal microbalance. An electronic nose or tongue using a QCM sensor array requires a multichannel frequency counter to detect the frequency shift of the sensors simultaneously. The frequency counter’s resolution, precision, and sampling speed are important factors. Board size, energy consumption, and rapid deployment are also considered in the design. This work shows the development of an independent multichannel frequency counter using a commercial Xilinx Spartan 6 series XC6SLX9 board module and a microcontroller board. Both modules are general-purpose modules; therefore, there is no need for a printed circuit board design, resulting in a quick implementation: the use of FPGA results in a compact size and low energy consumption. The developed counter is designed based on a reciprocal counter utilizing the internal logic block of the FPGA. The FPGA module has a built-in 50 MHz TCXO clock and is the reference clock. The high-resolution timing of the counter is realized by multiplying the 50 MHz clock by 6 to reach 300 MHz. The multiplication utilizes the PLL modules in the FPGA. The high precision and accuracy of the counter are achieved by calibrating the timing clock to a 10 MHz rubidium oscillator. The data communication to the microcontroller is done via the SPI by implementing the SPI protocol in the FPGA. The resource is optimized by utilizing PLL and DSP blocks for the counter. Only 5% registers and 5% LUTs of the FPGA resource are used to build a four-channel frequency counter. The result shows that the counter can measure the frequency of incoming signals with a resolution of 0.033 Hz at 10 MHz with a sampling time of 1 second. The system has been tested to monitor the frequency changes of a QCM sensor array.
Long‐Term Clinical and Safety Outcomes of Canaloplasty Performed across All Grades of Glaucoma Severity
Authors: Patel Shamil , Reiss George
Published: May 2023

Purpose. To investigate the clinical effectiveness of canaloplasty performed with an ab interno technique using the iTrack microcatheter (Nova Eye Medical) in patients with mild‐moderate glaucoma as compared to severe glaucoma. Methods. This is a retrospective single‐center case series. Patients were preoperatively categorized as mild/moderate vs. severe glaucoma assessed using the mean deviation (MD) score and controlled group (baseline intraocular pressure (IOP) ≤18 mmHg) vs. uncontrolled group (>18 mmHg). All patients with glaucoma were eligible for recruitment except those who had undergone previous glaucoma surgery (with the exception of selective laser trabeculoplasty or SLT). Patients underwent canaloplasty via an ab interno surgical technique with or without phacoemulsification and were monitored for IOP, glaucoma medication usage, and surgical complications. Results. In total, 72 eyes were followed for 3.4 ± 0.5 years. Mean pre‐op IOP (mmHg) was 19.3 ± 7.7 in the standalone group (n = 9) and 18.5 ± 5.6 in the combined group (n = 63) (p = 0.38). At the last follow‐up, mean IOP reduced by 36% to 12.4 ± 4.4 (p = 0.02) in the standalone group and by 26% to 13.7 ± 4.8 in the combined group (p < 0.001). Mean pre‐op IOP (mmHg) was 18.6 ± 5.2 in the severe group (n = 24) and 18.6 ± 6.2 in the mild‐moderate group (n = 48) (p = 0.48). Mean IOP was 14.1 ± 6.3 (−24%; p < 0.001) and 13.3 ± 3.7 (−29%; p < 0.001), respectively, at the last follow‐up. Mean glaucoma medication usage decreased from 2.5 ± 0.9 to 2.1 ± 0.9 (−15%; p = 0.083) in the severe group and 2.3 ± 1.0 to 1.4 ± 1.3 (−40%; p < 0.001) in the mild/moderate group. There was one localized Descemet’s membrane detachment in the moderate group. Conclusion. iTrack canaloplasty achieved a statistically significant IOP reduction in mild‐moderate and severe eyes and was found to be an effective option for reducing IOP and medications in patients with mild‐moderate primary open‐angle glaucoma (POAG). In severe eyes, it has reduced IOP while the medications remained stable.
Modeling Cholera Epidemiology Using Stochastic Differential Equations
Authors: Iddrisu Wahab A. , Iddrisu Inusah , Iddrisu Abdul-Karim
Published: May 2023

In this study, we extend Codeço’s classical SI-B epidemic and endemic model from a deterministic framework into a stochastic framework. Then, we formulated it as a stochastic differential equation for the number of infectious individuals

I

t

under the role of the aquatic environment. We also proved that this stochastic differential equation (SDE) exists and is unique. The reproduction number,

R

0

, was derived for the deterministic model, and qualitative features such as the positivity and invariant region of the solution, the two equilibrium points (disease-free and endemic equilibrium), and stabilities were studied to ensure the biological meaningfulness of the model. Numerical simulations were also carried out for the stochastic differential equation (SDE) model by utilizing the Euler-Maruyama numerical method. The method was used to simulate the sample path of the SI-B stochastic differential equation for the number of infectious individuals

I

t

, and the findings showed that the sample path or trajectory of the stochastic differential equation for the number of infectious individuals

I

t

is continuous but not differentiable and that the SI-B stochastic differential equation model for the number of infectious individuals

I

t

fluctuates inside the solution of the SI-B ordinary differential equation model. Another significant feature of our proposed SDE model is its simplicity.
Morphology-Based Spell Checker for Dawurootsuwa Language
Authors: Gamu Dawit Tadesse , Woldeyohannis Michael Melese
Published: May 2023

Processing of textual information by using word-processing tools is extremely increased due to the presence of misspelled or erroneous words. In order to minimize these misspelled words from digital information, different spellchecker tools are needed. A plenty of works are performed in technological favored languages like English and European languages but not for an underresourced language like Dawurootsuwa. The primary idea behind a morphology-based spellchecker is to use a dictionary lookup approach with morphological properties of the language to reduce dictionary size while also handling word inflection, derivation, and compounding. Two distinct tests were carried out in this work to evaluate the performance of a morphology-based spellchecker: error detection and error correction. The Hunspell dictionary format was utilized to construct the root words in this study, which included a total of 5,000 root words and more than 2,500 morphological rules along with 3,156 unique words for testing. The experimental result showed the overall spell error detection performance of 90.4% and the overall spell error correction performance of 79.31%. Moreover, we are working further towards developing a real word spelling checker that incorporate more numbers of language rules.
Two Rare Diseases, One Patient: A Case Report of Mucormycosis and Granulomatous Polyangiitis
Authors: Aasia Batool Syeda , Kumari Usha , Surani Salim
Published: May 2023

Mucormycosis is a rare but fatal disease caused by a filamentous fungus involving the nose, paranasal sinuses, and brain. These organisms usually cause severe infections in immunocompromised individuals. Granulomatous polyangiitis (GPA), also known as Wegner’s granulomatosis, is a rare, aseptic necrotizing granulomatous vasculitis involving small and medium-sized vessels commonly affecting the nose, ears, lungs, and kidneys. The simultaneous occurrence of mucormycosis and GPA, two rare diseases, in the same patient is exceedingly rare. In this case study, we describe a 40-year-old woman who presented with manifestations of both GPA and mucormycosis. She was started with steroids and antifungal agents and achieved significant improvement.
Design of a Bandpass Filter with Mixed Electromagnetic Coupling Paths Using Vertical Split-Ring Resonators
Authors: Lim Jaehyuk , Yoo Hogeun , Lee Jaehoon
Published: May 2023

We propose bandpass filters (BPFs) with mixed electromagnetic coupling paths (MEMCPs) that comprise two coupled vertical split-ring resonators (VSRRs) and present the equivalent circuit models of the coupled VSRRs. We demonstrate that the dominant coupling modes for the top and bottom layers of the VSRRs are magnetic (M) and electric (E), respectively, and that M-dominant coupling is required for high-selectivity BPFs. BPFs with narrow and wide bandwidths were designed based on the generalized coupling matrix. The proposed BPFs were fabricated and measured, and it is verified that the proposed BPFs have high selectivity due to the transmission zeros and a small circuit footprint due to the vertical structure of resonators. The fabricated narrow- and wide-band BPFs have the fractional bandwidths of 3.62% and 5.81%, respectively, with the overall size of

0.29

λ

g

×
0.043

λ

g

.
A State‐of‐the‐Art Computer Vision Adopting Non‐Euclidean Deep‐Learning Models
Authors: Chowdhury Sakib H. , Sany Md. Robius , Ahamed Md. Hafiz , Das Sajal K. , Badal Faisal Rahman , Das Prangon , Tasneem Zinat , Hasan Md. Mehedi , Islam Md. Robiul , Ali Md. Firoj , Abhi Sarafat Hussain , Islam Md. Manirul , Sarker Subrata Kumar
Published: May 2023

A distance metric known as non‐Euclidean distance deviates from the laws of Euclidean geometry, which is the geometry that governs most physical spaces. It is utilized when Euclidean distance is inappropriate, for as when dealing with curved surfaces or spaces with complex topologies. The ability to apply deep learning techniques to non‐Euclidean domains including graphs, manifolds, and point clouds is made possible by non‐Euclidean deep learning. The use of non‐Euclidean deep learning is rapidly expanding to study real‐world datasets that are intrinsically non‐Euclidean. Over the years, numerous novel techniques have been introduced, each with its benefits and drawbacks. This paper provides a categorized archive of non‐Euclidean approaches used in computer vision up to this point. It starts by outlining the context, pertinent information, and the development of the field’s history. Modern state‐of‐the‐art methods have been described briefly and categorized by application fields. It also highlights the model’s shortcomings in tables and graphs and shows different real‐world applicability. Overall, this work contributes to a collective information and performance comparison that will help enhance non‐Euclidean deep‐learning research and development in the future.
Ethnobotanical Study on Wild Edible Plants in Metema District, Amhara Regional State, Ethiopia
Authors: Masresha Getinet , Melkamu Yirgalem , Walle Getnet Chekole
Published: May 2023

Wild edible plants are vital for the survival and sustainable livelihoods of rural people of Ethiopia. Thus, this study compiled wild edible plants, their use, threats, and management practices in Metema District, northwestern Ethiopia. Eight sample kebeles were selected purposively based on vegetation coverage and key informants availability. A total of 128 informants were selected using purposive and random sampling techniques. Data were collected using individual interviews, guided field walks, focus group discussion, and market surveys through semistructured questionnaires. Ethnobotanical data collected from the informants were summarized by descriptive statistics, and further verified by using informant consensus, preference, and direct matrix ranking. Knowledge difference among age and sex groups was evaluated by independent sample t-test. A total of 44 wild edible plant species distributed in 34 genera and 25 families were documented. Most (88.64%) of these plant species were found in the wild habitat. Fabaceae and Moraceae accounted for higher proportion of edible plant species. Trees were the dominant habit (59.09%). From the total recorded wild edible plants, 33 (75%) species were used as supplementary foods and 11 (25%) species were used during famine. Fruits were the most edible plant parts (66%) and raw fresh forms were the main conditions of consumption (81.8%). Diospyros abyssinica was the most cited (60.94%) and first ranked. Some edible species such as Adansonia digitata and Balanites aegyptiaca were marketable. Ziziphus spina-christi was found the most multipurpose wild edible plant species. Most of the species (33, 75%) were used as animal fodder followed with traditional medicines (25, 56.82%) and firewood (20, 45.45%). Tamarindus indica, Moringa stenopetala, Balanites aegyptiaca, Grewia ferruginea, Corchorus olitorius, and Cordia africana had nutraceutical values. Significant knowledge differences (

P
<
0.05

) were obtained among sexes and age groups of informants on the number of wild edible plant species they listed. As a result of their multiple roles, wild edible plants are threatened by various anthropogenic activities. Despite this, Metema District still supports good numbers of wild edible plants from which the poor inhabitants complement their basic needs by consuming and marketing them. For sustainable utilization, conservation, value addition, and market linkage practices shall be strengthened to improve the livelihoods of local people and sustainable forest management.
Key Elements Affecting the Library’s CFU Concentration in Taiwan
Authors: Chang Bang-Lee , Tien Han-Kuang , Lin Yong-Jun , Hsiao Gary Li-Kai
Published: May 2023

Public libraries are popular gathering places, so understanding the factors that contribute to colony-forming unit (CFU) concentrations and how to minimize them is essential. This study aimed to investigate the factors that affect CFU concentrations in a public library, using air sampling (Bioluminescent ATP-assay) and statistical analysis software (SPSS) to collect and analyze data. The findings indicated that the CFU concentration in the library was significantly influenced by the air quality surrounding the building, the number of library visitors, and the hygiene and health of both visitors and employees. Additionally, indoor temperature and humidity were found to be key factors affecting CFU concentration. These findings suggest the need for better ventilation and air filtration systems, as well as regular cleaning and disinfection in public libraries. Furthermore, research is recommended to investigate other potential factors that may impact indoor air quality in public spaces.
Workload-Aware WiNoC Design with Intelligent Reconfigurable Wireless Interface
Authors: Wang Qi , Ouyang Yiming , Huang Zhengfeng , Liang Huaguo
Published: May 2023

By introducing wireless interfaces in conventional wired routers or hubs, wireless network-on-chip (WiNoC) is proposed to relieve congestion pressure from high volume inter-subnet data transmission. Generally, processing elements on chip receive input data and return feedback through network interface, and data transmission function in Network-on-Chip (NoC) is completed by routers. Hubs equipped with wireless interface are fixed to certain wired routers. While wireless channels may not be fully utilized due to unbalanced workload and constant hub-router connection, e.g., certain nodes processing excess inter-subnet data traffic are far away from hubs. In this paper, we proposed a workload-aware WiNoC design with intelligent reconfigurable wireless interface to improve wireless resources utilization and mitigate congestion. Through multidimensional analysis of traffic flow, a 4-layer neural network is trained offline and applied to analyze workload in each tile, and return three most potential tiles for wireless interface reconfiguration to fully utilize wireless channel and lowing latency. We also implement a historical traffic information-based reconfigurable scheme for comparation. Evaluation results show that in an 8 × 8 hybrid mesh topology, the proposed scheme can achieve 10%–16% reduction in network latency and 5%–11% increment in network throughput compared with fixed-link hub-node connection scheme under several mixed traffic patterns.
Some Intuitionistic Cubic Fuzzy Muirhead Mean Operators with Their Application to Multicriteria Decision Making
Authors: Liu Yan , Yang Zhaojun , He Jialong , Yu Lijuan , Zhong Yuan
Published: May 2023

Intuitionistic cubic fuzzy sets (ICFSs), as a hybrid fuzzy set consisting of interval‐valued fuzzy sets and intuitionistic fuzzy sets, can deal with the uncertainty of information in decision problems more comprehensively. Muirhead mean (MM) operators can deal with the correlation between attributes in decision problems more realistically. However, there has been no research on MM operators under intuitionistic cubic fuzzy sets so far. In this study, some new operators are proposed under the intuitionistic cubic fuzzy set. It contains the intuitionistic cubic fuzzy MM (ICFMM) operator, intuitionistic cubic fuzzy weighted MM (ICFWMM) operator, intuitionistic cubic fuzzy dual MM (ICFDMM) operator, and intuitionistic cubic fuzzy dual weighted MM (ICFDWMM) operator. Their proof procedure, properties, and proof of properties are given. Two MCDM decision models based on ICFWMM and ICFDWMM operators are proposed, and the proposed decision models are applied to supplier selection, and the better reliability and accuracy of the proposed decision methods in this study are verified through comparative analysis with existing methods.
An Efficient Algorithm for Decomposition of Partially Ordered Sets
Authors: Badr Elsayed , EL-Hakeem Mohamed , El-Sharawy Enas E. , Ahmed Thowiba E.
Published: May 2023

Efficient time complexities for partial ordered sets or posets are well-researched field. Hopcroft and Karp introduced an algorithm that solves the minimal chain decomposition in O (n2.5) time. Felsner et al. proposed an algorithm that reduces the time complexity to O (kn2) such that n is the number of elements of the poset and k is its width. The main goal of this paper is proposing an efficient algorithm to compute the width of a given partially ordered set P according to Dilworth’s theorem. It is an efficient and simple algorithm. The time complexity of this algorithm is O (kn), such that n is the number of elements of the partially ordered set P and k is the width of P. The computational results show that the proposed algorithm outperforms other related algorithms.
Supplemental Table S1 from Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma
Authors: Kelly William , Diaz Duque Adolfo Enrique , Michalek Joel , Konkel Brandon , Caflisch Laura , Chen Yidong , Pathuri Sarath Chand , Madhusudanannair-Kunnuparampil Vinu , Floyd John , Brenner Andrew
Published: May 2023

Representativeness of Study Participants
Supplemental Figure S3 from Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma
Authors: Kelly William , Diaz Duque Adolfo Enrique , Michalek Joel , Konkel Brandon , Caflisch Laura , Chen Yidong , Pathuri Sarath Chand , Madhusudanannair-Kunnuparampil Vinu , Floyd John , Brenner Andrew
Published: May 2023

Overall Survival by Exosome (50-120nm N=24) Concentration Relative Change (< -0.01, > -0.01): p=0.57 [<-0.01: median=8.9, 95% CI 5.1 to 17.5, >-0.01: median=8.3 95% CI 4.0, 14.1]
Supplementary Video S1 from First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Authors: Duan Xiaojiang , Xia Lei , Zhang Zhuochen , Ren Yanan , Pomper Martin G. , Rowe Steven P. , Li Xuesong , Li Nan , Zhang Ning , Zhu Hua , Yang Zhi , Sheng Xinan , Yang Xing
Published: May 2023

40 min full dynamic Total-body PET imaging of healthy volunteers
Data from First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Authors: Duan Xiaojiang , Xia Lei , Zhang Zhuochen , Ren Yanan , Pomper Martin G. , Rowe Steven P. , Li Xuesong , Li Nan , Zhang Ning , Zhu Hua , Yang Zhi , Sheng Xinan , Yang Xing
Published: May 2023

AbstractPurpose:
Nectin-4 is an emerging biomarker for cancer diagnosis and therapy. Recently, enfortumab vedotin (EV) was approved by the FDA as the first nectin-4 targeting antibody–drug conjugate for treating advanced urothelial carcinoma (UC). A PET imaging method to noninvasively quantify nectin-4 expression level would potentially help to select patients most likely to respond to EV and predict the response.
Experimental Design:
In this study, we designed a bicyclic peptide-based nectin-4 targeting radiotracer 68Ga-N188. Initially, we performed preclinical evaluations of 68Ga-N188 in UC cell lines and xenograft mouse models. Next, we performed the translational study in healthy volunteers and a pilot cohort of patients with advanced UC on uEXPLORER total-body PET/CT.
Results:
In the preclinical study, 68Ga-N188 showed high affinity to nectin-4, specific uptake in a nectin-4(+) xenograft mouse model, and suitable pharmacokinetic and safety profiles. In the translational study, 2 healthy volunteers and 14 patients with advanced UC were enrolled. The pharmacokinetic profile was determined for 68Ga-N188, and the nectin-4 relative expression level in different organs was quantitatively imaged.
Conclusions:
A clear correlation between PET SUV value and nectin-4 expression was observed, supporting the application of 68Ga-N188 PET as a companion diagnostic tool for optimizing treatments that target nectin-4.
Figure S7 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

The western diet causes chronic pro-tumorigenic inflammation.
Figure S5 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

Single cell RNAsequencing following 4 days of dietary switch, or then switch back and comparison to pathways altered in stem cells by Ppargc1a genetic inactivation.
Supplementary Data from Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer
Authors: Adams Clare M. , Mitra Ramkrishna , Xiao Youcai , Michener Peter , Palazzo Juan , Chao Allen , Gour Jitendra , Cassel Joel , Salvino Joseph M. , Eischen Christine M.
Published: May 2023

Supplementary Materials and Methods, Tables S1-S3, Figures S1-S7
TABLE 3 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

Response
Figure S11 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Differential methylation analysis (C vs S).
Figure S1 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Collection and selection of tumor samples.
FIGURE 3 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Differential expression and methylation analysis (C vs. S). A, Heatmap and pathway overrepresentation analysis of differentially expressed genes between C and S (or undifferentiated) components of the 10 samples derived from the five selected CS tumors. Gene clustering method: Ward's; distance: Spearman. FDR: false discovery rate. B, Heatmaps of EMT and stemness pathways scores (left) and methylation level of EMT-related miRNAs (right). mRNA level: scaled TPM. Pathway scores: scaled ssGSEA scores. Methylation level: scaled beta-values.
Supplementary Table 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Authors: Terzo Esteban , Apte Shruti A , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: May 2023

Table showing the top 20 MYC gene targets with the highest positive charge density
A documentação histórica arquitetônica: conceitos historiográficos para a fragmentação do tempo
Authors: Mezalira Mariela , Moreira Daniel de Carvalho
Published: May 2023

A compreensão histórica arquitetônica exige múltiplos panoramas para transmissão do conhecimento acerca da conceituação e materialização da disciplina. A documentação por livros de história da arquitetura, possibilita leituras contemporâneas de registros, esboçando mudanças temporais conforme as narrativas documentadas fundamentam eventos, artefatos, genealogias e interpretações historiográficas arquitetônicas em multiplicidade de vozes autorais, enunciando diferentes composições e percepções do tempo. Intenções autorais buscam, nas construções narrativas, diferentes estratégias de seleção e divisão de passagens históricas em unidades arquitetônicas conforme teorias, discursos ou parâmetros. A fragmentação da continuidade histórica da arquitetura possibilita abordagem por uma série classificatória de conceitos historiográficos para estruturação do conteúdo da publicação no tempo. O artigo propõe a revisão, de caráter teórico, desse cenário na articulação narrativa arquitetônica documental.
Produção do espaço urbano na região de São José do Rio Preto 2000-2020: a terra como investimento
Authors: Rossi Marcela Vanessa Santos , Otero Estevam Vanale
Published: May 2023

Neste início de século as cidades brasileiras vêm sendo palco de intensa produção imobiliária, fato marcante nas cidades do interior paulista, especialmente as chamadas cidades médias. Diversos indicadores revelam uma produção em larga escala nesses territórios que ultrapassa as relações estabelecidas entre oferta e demanda, apontando, como procuraremos demonstrar, para o papel do espaço urbano enquanto escoadouro de capitais em busca de valorização. O artigo procura expor as lógicas por trás desse cenário, sobretudo a partir da análise da produção de lotes urbanizados, tomando como recorte de estudo São José do Rio Preto e municípios vizinhos, que apresentam números bastante expressivos em termos de novos parcelamentos.
Essa nova Lesboa
Authors: Curopos Fernando
Published: May 2023

Como no resto da Europa, no segundo quartel de Oitocentos, Portugal viu emergir a figura da lésbica, moldada pelo discurso médico e pelos incipientes estudos sobre sexologia. O discurso médico difundirá um certo número de clichês, em particular a ligação entre lesbianismo e prostituição. Mas, no caso português, é sobretudo nos salões da elite que se encontram as lésbicas, na maioria das vezes mulheres casadas, que também levam uma vida dupla. O tema ganhará uma nova configuração no final da Primeira Guerra Mundial após a publicação do romance de Victor Margueritte, La Garçonne, o qual terá uma certa influência em Aragão Paiva, o primeiro autor português a encenar a versão lésbica dos loucos anos 20.
Na estrada para o safismo: uma comparação entre Amar, gozar, morrer e Nova Sapho
Authors: Silva Ana Beatriz , Maia Helder Thiago
Published: May 2023

O presente artigo tem por objetivo efetuar uma análise comparativa entre os romances Amar, gozar, morrer (s/d), de autoria anônima, e Nova Sapho (1912), do Visconde de Villa-Moura, tendo como principal interesse analisar o caráter erótico, a enunciação da lesbianidade, as viagens e as damas de companhia. Para tanto, nos baseamos na crítica lésbica (SANTOS, 2005), em especialistas na literatura pornográfica (EL FAR, 2004; MENDES, 2017), uma vez que as duas obras podem ser pensadas a partir do diálogo com essa categoria, e nos ideais propostos pela medicina no final do século XIX (SILVA, 1895; KRAFFT-EBING, 1893), que tanto influenciaram a produção literária desse período.
Pedagogia, tutela e a insondável beleza do corpo
Authors: Ji Renan
Published: May 2023

O artigo busca delinear como a trama naturalista de Bom crioulo, romance escrito por Adolfo Caminha em 1895, desestabiliza aspectos do cientificismo e da objetividade da escola literária a que supostamente se filia. Na representação do triângulo amoroso entre os personagens Amaro, D. Carolina e Aleixo, vemos a presença de elementos fortemente figurativos, que revelam não apenas o desejo de tutela e as projeções dos dois primeiros sobre o jovem Aleixo, mas principalmente o caráter profundamente imaginário e insondável da beleza deste jovem.
Divinas Divas: entre a janela e o espelho
Authors: Garcia Wilton
Published: May 2023

Este artigo é uma leitura sobre o filme documentário Divinas Divas (2017) dirigido por Leandra Leal. Como pressuposto de estratégia discursiva, metaforicamente, o documentário explora estados alternativos de (inter)mediação entre a janela e o espelho no universo travesti: do palco ao cotidiano e vice-versa. Tal pressuposição tangencia a produção cultural de (inter)subjetividades acerca da diversidade, ao pontuar categorias de flexibilidade e transversalidade diluídas ao longo do texto. Em formato ensaio, a proposta de leitura expõe argumentos sincréticos (verbais, visuais e sonoros), ancorados por estudos contemporâneos, a contextualizar a dinâmica documental de testemunhos e depoimentos.
Conservation, Animal Wellbeing, and Indigenous Participation at an Elephant Sanctuary in Mondulkiri, Cambodia
Authors: Kopnina Helen , Baker Liv
Published: May 2023

This article focuses on the intersection of indigenous peoples, conservation, and elephant wellbeing in Cambodia. While social justice advocates emphasize the human cost of conservation in human-animal conflicts, those concerned with animal protection and rights have problematized the treatment of elephants. This critique stems from evidence that the human relationship to elephants, captive and wild, remains largely utilitarian or exploitive. In Cambodia, there is a record of wild Asian elephants coexisting with local communities, but more so a long history of elephants used for labor. This article discusses the possible areas of reconciliation between human and Asian elephant interests at a Mondulkiri elephant sanctuary in Cambodia, suggesting potential paths toward win-win scenarios for the local and indigenous people, as well as for the elephants and their habitats.
Sulla sua passione per l’ascolto (Περὶ τῆς αὐτοῦ φιληκοΐας): l’orazione 19 di Dione di Prusa
Authors: Bernardi Gianluigi
Published: May 2023

A short text by Dio of Prusa is analyzed, regarding the orator’s personal judgment on kitharōidia and the relationship it has with sophistic art and tragic literature as means of cultural dissemination. The article aims to propose a plausible interpretation of the text, on the one hand by examining the (few) data provided by critical studies, and on the other, especially, by making use of the author’s main research work, carried out by collecting all the passages of musical interest and ‘sound events’ contained in Dio’s speeches.
The rediscovery of Impatiens sigmoidea Hook. f. (Balsaminaceae) in Guizhou, China after more than 100 years
Authors: HUANG RONG-XIN , CHEN YI , HE BAI-QIU , LI MEI-JUN , DONG WEN-KE , BAI XIN-XIANG
Published: May 2023

Impatiens sigmoidea was described in 1908 by the eminent British plant taxonomist J. D. Hooker based on specimens collected by the French missionaries E. M. Bodinier et al. from Guizhou, China. However, there has been no other records since then. After years of concern, we rediscovered I. sigmoidea in one of its type localities, Gao-po Town, in 2018. A revised description, colour photographs and a provisional IUCN Red List assessment of this species are provided, along with discussions of its geographical distribution, ecology and morphological comparison with I. lasiophyton. The lectotype of I. sigmoidea is also designated here. The rediscovery provides an essential basis for enriching the botanical resources of the genus Impatiens.
Ferula ermenekense (Apiaceae), an interesting new species from Southern Anatolia in the eastern Mediterraenean Basin
Authors: SAĞIROĞLU MEHMET , DUMAN HAYRİ
Published: May 2023

Ferula ermenekense is described and illustrated as a new species from Karaman province in South Anatolia, Turkey. Ferula ermenekense is morphologically close to F. lycia, F. duranii and F. pisidica. In this study, the diagnostic morphological features, distribution, conservation status, habitat and ecological characteristics of the new species are discussed. Micromorphological characteristics of F. ermenekense, F. lycia, F. duranii and F. pisidica mericarps are also examined and compared by using LM and SEM analyses.
Arrojadoa flava (Cactaceae, Cactoideae), a new yellow flowered species from the Brazilian flora
Authors: GONZAGA DIEGO RAFAEL , LIEBSCH DIETER , ENGELS MATHIAS ERICH
Published: May 2023

Arrojadoa flava is described on the basis of living collections and herbarium specimens. The new species is considered endemic to the Brazilian Caatinga (Municipality of Ibitiara, Bahia State). Comments on its morphology in comparison with the similar taxa, as well as geographical distribution, phenology, habitat, conservation status, and original photographs are provided. In terms of conservation, it was assessed according to IUCN criteria as Data Deficient (DD).