bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of residue degradation of cypermethrin and chlorpyrifos in brinjal, tomato and cauliflower under supervised field trial
Authors: Ahmed Md Sultan , Hossain Prodhan Mohammad Dalower , Begum Afroza , Afroze Marina , Sarker Debasish
Published: October 2021

A study was carried out to detect and estimate the residue of cypermethrin and chlorpyrifos in brinjal, tomato and cauliflower using Gas Chromatography (GC) coupled with Electron Capture Detector (ECD) and Flame Thermionic Detector (FTD). Three supervised field trials were conducted and sprayed with the recommended dose of cypermethrin (1 ml/L of water) and chlorpyrifos (3 ml/L of water) in three vegetables by knapsack sprayer. Samples were collected at 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 days after spray (DAS). The quantity of cypermethrin residue was above EU-MRLs (Maximum Residue Limit set by European Union) up to 4 DAS with 0.538 mg/kg in cauliflower; 3 DAS with 0.508 mg/kg in brinjal and 0.695 mg/kg in tomato. The quantity decreased down 0.328-0.019 mg/kg in cauliflower (4-9 DAS); 0.098-0.012 mg/kg (4-7 DAS) in brinjal and 0.458-0.022 mg/kg (4-7 DAS) in tomato which were below EU-MRLs (0.5 mg/kg). The quantity of chlorpyrifos residue was above EU-MRLs up to 9 DAS with 0.012 mg/kg in cauliflower but in brinjal and tomato, the detected quantities were above EU-MRLs up to 7 DAS with 0.029 mg/kg and 0.017 mg/kg residue. No residue was detected from brinjal and tomato samples collected at 8 DAS. But in cauliflower, no residue was detected at 10 days after spray. So, brinjal, tomato and cauliflower can be harvested safely at 4 DAS and 5 DAS for cypermethrin and in case of chlorpyrifos it was 8 DAS in brinjal and tomato and 10 DAS in cauliflower.
Asian Australas. J. Biosci. Biotechnol. 2021, 6 (2), 60-67
The Use of Directing Technologies in the System of Additional Education
Authors: Elena Ivanovna Grigorieva , Marina Gennadievna Kruglova , Olga Fyodorovna Asatryan , Nina Alexandrovna Oparina , Galina Ivanovna Gribkova , Natalia Sergeevna Yushchenko
Published: October 2021

The study deploys various research methods. The theoretical methods include analysis, summarization, comparison, synthesis, and systematization of scientific and educational methodical literature to determine the current state of the problem under study. The empirical methods comprise purposeful observation, conversations, interviewing, questionnaire, and testing. In addition, a pedagogical experiment is conducted to test the experimental methods of using directing technologies in organizing the musical-pedagogical process in additional education institutions. Statistical methods are used in quantitative and qualitative processing of the study results, the objectivity of the results is tested using Pearson’s consistency criterion χ2.The need for the formation of a directing space of musical pedagogy as an important condition for improving the professional mastery of teachers in additional education is substantiated. The major directions for the implementation of directing technologies for the development of specialists’ competencies are revealed. The directing space created in the process of lessons and the demonstration of students’ achievements in performance contributes to students’ musical, aesthetic and spiritual, and moral development, the improvement of their performance skills, and the development of motivation for educational and creative and performance activity.
Effects of Exercise Therapy on Anxiety and Depression in Patients With Coronary Heart Disease: A Meta-Analysis of a Randomized Controlled Study
Authors: Wang Lina , Sun Yangli , Zhan Jie , Wu Zhiyuan , Zhang Peiming , Wen Xiaopeng , Ge Shuqi , Han Xu , Lu Liming
Published: October 2021

Objective: The purpose of this review was to evaluate the effect of exercise therapy on anxiety and depression symptoms in patients with coronary heart disease (CHD).

Methods: A systematic review of papers published between January 2000 and February 2021 was conducted. MEDLINE, Embase, the Cochrane Library and Web of Science were searched. Meta-analysis was used to compare the results of the included studies. Bias risk assessment was performed using the Cochrane Collaboration bias risk tool. If half or more of the seven items in Randomized controlled trials (RCTs) were low-risk, then the RCT was considered low-risk research; otherwise, it was high-risk. Statistical analyses were performed using RevMan version 5.3 and STATA version 12.0.

Results: We performed a meta-analysis of 11 randomized clinical studies including 771 subjects. Eight studies (73%) were of high quality. Compared with the control group, the exercise group showed a significant improvement in anxiety [standard mean difference (SMD) = −0.61; 95% confidence interval (CI): −0.86, −0.35]. The depression level in the exercise group was also significantly reduced (SMD = −0.48; 95% CI: −0.92, −0.04). Aerobic fitness and athletic endurance also improved [mean difference (MD) = 0.77; 95% CI: 0.58, 0.95; and MD = 20.69; 95% CI: 6.91, 34.46; respectively].

Conclusions: This meta-analysis suggests that exercise therapy may be effective in alleviating anxiety and depression symptoms in patients with coronary heart disease. Due to methodological weaknesses, rigorous research needs to be designed to further confirm the effectiveness of exercise therapy in improving the mental health of patients with coronary heart disease.

Systematic Review Registration:https://inplasy.com/projects/, identifier: INPLASY202160017.
Biomorphogenic Feedbacks and the Spatial Organization of a Dominant Grass Steer Dune Development
Authors: Bonte Dries , Batsleer Femke , Provoost Sam , Reijers Valérie , Vandegehuchte Martijn L. , Van De Walle Ruben , Dan Sebastian , Matheve Hans , Rauwoens Pieter , Strypsteen Glenn , Suzuki Tomohiro , Verwaest Toon , Hillaert Jasmijn
Published: October 2021

Nature-based solutions to mitigate the impact of future climate change depend on restoring biological diversity and natural processes. Coastal foredunes represent the most important natural flood barriers along coastlines worldwide, but their area has been squeezed dramatically because of a continuing urbanization of coastlines, especially in Europe. Dune development is steered by the development of vegetation in interaction with sand fluxes from the beach. Marram grass (Calamagrostis arenaria, formerlyAmmophila arenaria) is the main dune building species along most European coasts, but also in other continents where the species was introduced. Engineering of coastal dunes, for instance by building dunes in front of dikes, needs to be based on a solid understanding of the species’ interactions with the environment. Only quantitative approaches enable the further development of mechanistic models and coastal management strategies that encapsulate these biomorphogenic interactions. We here provide a quantitative review of the main biotic and physical interactions that affect marram grass performance, their interactions with sand fluxes and how they eventually shape dune development. Our review highlights that the species’ spatial organization is central to dune development. We further demonstrate this importance by means of remote sensing and a mechanistic model and provide an outlook for further research on the use of coastal dunes as a nature-based solution for coastal protection.
Dynamics of Nutrients and Colored Dissolved Organic Matter Absorption in a Wetland-Influenced Subarctic Coastal Region of Northeastern Japan: Contributions From Mariculture and Eelgrass Meadows
Authors: Isada Tomonori , Abe Hiroya , Kasai Hiromi , Nakaoka Masahiro
Published: October 2021

Coastal oceans interacting with terrestrial ecosystems play an important role in biogeochemical cycles. It is therefore essential to research land–ocean interactions for further understanding of the processes influencing nutrients dynamics in coastal areas. We investigated the seasonal and spatial distribution of nutrient concentrations and light absorption coefficients of colored dissolved organic matter (CDOM), non-algal particles (NAP), and phytoplankton in a wetland-influenced river–eelgrass meadows–coastal waters continuum in the protected and semi-enclosed coastal sea of Akkeshi-ko estuary (AKE) and Akkeshi Bay (AB), Japan from April 2014 to February 2015. The mixing dilution lines of the CDOM absorption coefficient at 355 nm [aCDOM(355)] relative to salinity predicted by two end-members between freshwater and coastal water showed conservative mixing in AB. Silicate concentrations were significantly correlated with salinity and aCDOM(355) in AB in each month except for December 2014. These results suggest that silicate and CDOM in AB primarily originates from wetland-influenced river discharge. However, samples collected from the eelgrass meadows of AKE, where mariculture is developed, showed non-conservative mixing of silicate concentrations and aCDOM(355) with salinity except for June 2014. Elevated phosphate concentrations, probably released from sediments, were also found in the eelgrass meadows of AKE, especially during summer. These results suggest that the metabolic activities of mariculture and seagrass ecosystem significantly contribute to the nutrient cycles and CDOM absorption in AKE and to the distinct water-mass systems inside and outside AKE. The relative absorption properties of NAP [aNAP(443)], phytoplankton [aph(443)], and aCDOM(443) showed that CDOM is the main factor affecting the light distribution in AKE. However, the relative absorption properties varied seasonally in AB because of spring and autumn phytoplankton blooms and ice cover during winter. Significant relationships were observed between the Secchi disk depth (ZSD), aNAP(443), and aCDOM(443). Chl a concentration and aph(443) were not good indicators for predicting ZSD in our study region. These results suggest that incorporating inherent optical properties and CDOM from mariculture and seagrass ecosystem into ecosystem models could improve predictions of light distribution along the freshwater–eelgrass–coastal waters continuum in optically complex coastal waters.
Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles
Authors: Gao Ning , Huang Zhihui , Xing Jianing , Zhang Siyi , Hou Jing
Published: October 2021

The adverse effects of microplastics (MPs) in aquatic environments have attracted increasing attention and posed health risks along with nanomaterials. Therefore, the toxic effects of polystyrene microplastics (PS-MPs) with different particle sizes (0.07, 0.7 and 7 μm) on zebrafish in the presence and absence of copper nanoparticles (Cu-NPs) were evaluated. The acute toxicity of MPs on zebrafish was 7 μm > 0.07 μm > 0.7 μm. Both 0.07 and 7 μm MPs acted on chromosomes and significantly affected cell cycle process by affecting palmitoyl hydrolase activity; while 0.7 μm MPs acted on extracellular space and significantly affected the activity of endopeptidase inhibitor to affect the cholesterol transport. And 0.07 and 7 μm MPs dominantly affected “cell cycle” pathway by inhibiting DNA replication, delaying the progression of S phase and G2/M phase, and affecting the accurate arrangement and separation of chromosomes; while the 0.7 μm MPs activated numerous platelets to aggregate and adhere in damaged parts, enhanced the coagulation function of platelets, and promoted the formation of fibrin clots, thus abnormally activating the “hemostasis” pathway. The presence of Cu-NPs significantly changed the toxicity-related pathways induced by 7 μm MPs from “cell cycle” into “hemostasis,” but not for the smaller-sized MPs (0.07 and 0.7 μm). The combined exposure of Cu-NPs and 7 μm MPs acted on the extracellular region and significantly affected cholesterol transport by affecting the activity of cholesterol transporters. This study provides theoretical insights for the health risks of MPs to aquatic species and even humans in the actual ecosystem.
Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
Authors: Ermel Aaron , Thyvalikakath Thankam Paul , Foroud Tatiana , Khan Babar , Srinivasan Mythily
Published: October 2021

Emerging concerns following the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) pandemic are the long-term effects of coronavirus disease (COVID)-19. Dysgeusia in COVID-19 is supported by the abundant expression of the entry receptor, angiotensin-converting enzyme-2 (ACE2), in the oral mucosa. The invading virus perturbs the commensal biofilm and regulates the host responses that permit or suppress viral infection. We correlated the microbial recognition receptors and soluble ACE2 (sACE2) with the SARS-CoV2 measures in the saliva of COVID-19 patients. Data indicate that the toll-like receptor-4, peptidoglycan recognition protein, and sACE2 are elevated in COVID-19 saliva and correlate moderately with the viral load.
Analysis of Correlation Between White Matter Changes and Functional Responses in Post-stroke Depression
Authors: Zhang Xuefei , Shi Yu , Fan Tao , Wang Kangling , Zhan Hongrui , Wu Wen
Published: October 2021

Objective: Post-stroke depression (PSD) is one of the most common neuropsychiatric symptoms with high prevalence, however, the mechanism of the brain network in PSD and the relationship between the structural and functional network remain unclear. This research applies graph theory to structural networks and explores the relationship between structural and functional networks.

Methods: Forty-five patients with acute ischemic stroke were divided into the PSD group and post-stroke without depression (non-PSD) group respectively and underwent the magnetic resonance imaging scans. Network construction and Module analysis were used to explore the structural connectivity-functional connectivity (SC-FC) coupling of multi-scale brain networks in patients with PSD.

Results: Compared with non-PSD, the structural network in PSD was related to the reduction of clustering and the increase of path length, but the degree of modularity was lower.

Conclusions: The SC-FC coupling may serve as a biomarker for PSD. The similarity in SC and FC is associated with cognitive dysfunction, retardation, and desperation. Our findings highlighted the distinction in brain structural-functional networks in PSD.

Clinical Trial Registration: https://www.clinicaltrials.gov/ct2/show/NCT03256305, NCT03256305.
Parkinson’s Disease Dementia: Synergistic Effects of Alpha-Synuclein, Tau, Beta-Amyloid, and Iron
Authors: Han Jiajun , Fan Yaohua , Wu Peipei , Huang Zifeng , Li Xinrong , Zhao Lijun , Ji Yichun , Zhu Meiling
Published: October 2021

Parkinson’s disease dementia (PDD) is a common complication of Parkinson’s disease that seriously affects patients’ health and quality of life. At present, the process and pathological mechanisms of PDD remain controversial, which hinders the development of treatments. An increasing number of clinical studies have shown that alpha-synuclein (α-syn), tau, beta-amyloid (Aβ), and iron are closely associated with PDD severity. Thus, we inferred the vicious cycle that causes oxidative stress (OS), due to the synergistic effects of α-syn, tau, Aβ, and, iron, and which plays a pivotal role in the mechanism underlying PDD. First, iron-mediated reactive oxygen species (ROS) production can lead to neuronal protein accumulation (e.g., α-syn andAβ) and cytotoxicity. In addition, regulation of post-translational modification of α-syn by iron affects the aggregation or oligomer formation of α-syn. Iron promotes tau aggregation and neurofibrillary tangles (NFTs) formation. High levels of iron, α-syn, Aβ, tau, and NFTs can cause severe OS and neuroinflammation, which lead to cell death. Then, the increasing formation of α-syn, Aβ, and NFTs further increase iron levels, which promotes the spread of α-syn and Aβ in the central and peripheral nervous systems. Finally, iron-induced neurotoxicity promotes the activation of glycogen synthase kinase 3β (GSK3β) related pathways in the synaptic terminals, which in turn play an important role in the pathological synergistic effects of α-syn, tau and Aβ. Thus, as the central factor regulating this vicious cycle, GSK3β is a potential target for the prevention and treatment of PDD; this is worthy of future study.
The Use of Supervised Learning Models in Studying Agonistic Behavior and Communication in Weakly Electric Fish
Authors: Pedraja Federico , Herzog Hendrik , Engelmann Jacob , Jung Sarah Nicola
Published: October 2021

Despite considerable advances, studying electrocommunication of weakly electric fish, particularly in pulse-type species, is challenging as very short signal epochs at variable intervals from a few hertz up to more than 100 Hz need to be assigned to individuals. In this study, we show that supervised learning approaches offer a promising tool to automate or semiautomate the workflow, and thereby allowing the analysis of much longer episodes of behavior in a reasonable amount of time. We provide a detailed workflow mainly based on open resource software. We demonstrate the usefulness by applying the approach to the analysis of dyadic interactions ofGnathonemus petersii. Coupling of the proposed methods with a boundary element modeling approach, we are thereby able to model the information gained and provided during agonistic encounters. The data indicate that the passive electrosensory input, in particular, provides sufficient information to localize a contender during the pre-contest phase, fish did not use or rely on the theoretically also available sensory information of the contest outcome-determining size difference between contenders before engaging in agonistic behavior.
Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders
Authors: Ruggiero Rafael Naime , Rossignoli Matheus Teixeira , Marques Danilo Benette , de Sousa Bruno Monteiro , Romcy-Pereira Rodrigo Neves , Lopes-Aguiar Cleiton , Leite João Pereira
Published: October 2021

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in executive and emotional functions. Neurophysiological studies have begun to unveil the dynamics of HPC-PFC interaction in both immediate demands and long-term adaptations. Disruptions in HPC-PFC functional connectivity can contribute to neuropsychiatric symptoms observed in mental illnesses and neurological conditions, such as schizophrenia, depression, anxiety disorders, and Alzheimer’s disease. Given the role in functional and dysfunctional physiology, it is crucial to understand the mechanisms that modulate the dynamics of HPC-PFC communication. Two of the main mechanisms that regulate HPC-PFC interactions are synaptic plasticity and modulatory neurotransmission. Synaptic plasticity can be investigated inducing long-term potentiation or long-term depression, while spontaneous functional connectivity can be inferred by statistical dependencies between the local field potentials of both regions. In turn, several neurotransmitters, such as acetylcholine, dopamine, serotonin, noradrenaline, and endocannabinoids, can regulate the fine-tuning of HPC-PFC connectivity. Despite experimental evidence, the effects of neuromodulation on HPC-PFC neuronal dynamics from cellular to behavioral levels are not fully understood. The current literature lacks a review that focuses on the main neurotransmitter interactions with HPC-PFC activity. Here we reviewed studies showing the effects of the main neurotransmitter systems in long- and short-term HPC-PFC synaptic plasticity. We also looked for the neuromodulatory effects on HPC-PFC oscillatory coordination. Finally, we review the implications of HPC-PFC disruption in synaptic plasticity and functional connectivity on cognition and neuropsychiatric disorders. The comprehensive overview of these impairments could help better understand the role of neuromodulation in HPC-PFC communication and generate insights into the etiology and physiopathology of clinical conditions.
Clinical Implication of Caloric and Video Head Impulse Tests for Patients With Enlarged Vestibular Aqueduct Presenting With Vertigo
Authors: Li Ming , Leng Yangming , Liu Bo
Published: October 2021

Background: By examining the clinical features and results of video head impulse test (vHIT) and caloric tests in patients with enlarged vestibular aqueduct (EVA) presenting with vertigo, we aimed to investigate the function of angular vestibulo-ocular reflex (VOR) and its clinical implications.

Methods: Nine patients with EVA manifesting with vertigo were enrolled. The medical history, audiological examination, imaging, and the results of the caloric test and the vHIT were analyzed.

Results: Of the nine patients with EVA (eight bilateral and one unilateral case), five were pediatric cases. All 17 ears exhibited sensorineural hearing loss (SNHL). Enlarged vestibular aqueduct patients can present with recurrent (seven cases) or single (two cases) vertigo attack, trauma-induced (two cases), or spontaneous (seven cases) vertigo. Diminished caloric responses were observed in 77.8% (7/9) of the patients (four cases unilaterally and three bilaterally), while unilateral abnormal vHIT results in 11.1% (1/9) patients. Abnormal caloric and normal horizontal vHIT responses were found in 66.7% (6/9) of EVA patients.

Conclusions: Vestibular manifestations in EVA are diverse. Enlarged vestibular aqueduct patients with vertigo can present with a reduced caloric response and normal horizontal vHIT, and this pattern of angular VOR impairment was also found in other hydropic ear diseases.
Prevalence and Prognostic Value of Malnutrition Among Elderly Cancer Patients Using Three Scoring Systems
Authors: Zhang Qi , Qian Liang , Liu Tong , Ding Jia-Shan , Zhang Xi , Song Meng-Meng , Wang Zi-Wen , Ge Yi-Zhong , Hu Chun-Lei , Li Xiang-Rui , Tang Meng , Wang Kun-Hua , Barazzoni Rocco , Song Chun-Hua , Xu Hong-Xia , Shi Han-Ping ,   Investigation on Nutrition Status and Its Clinical Outcome of Common Cancers (INSCOC) Group
Published: October 2021

Background: Malnutrition is common in patients with cancer and is associated with adverse outcomes, but few data exist in elderly patients. The aim of this study was to report the prevalence of malnutrition using three different scoring systems and to examine the possible clinical relationship and prognostic consequence of malnutrition in elderly patients with cancer.

Methods: Nutritional status was assessed by using controlling nutritional status (CONUT), the prognostic nutritional index (PNI), and the nutritional risk index (NRI). Quality-of-life (Qol) was assessed during admission by using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30. Performance status (PS) was assessed by using the Eastern Cooperative Oncology Group (ECOG) classification. The relationship between nutritional status and overall survival and Qol were examined.

Results: Data were available for 1,494 elderly patients with cancer (63.65% male), the mean age was 70.76 years. According to the CONUT, NRI, and PNI, 55.02, 58.70, and 11.65% patients were diagnosed with malnutrition, respectively. Worse nutritional status was related to older, lower BMI, lower hand grip strength, and more advanced tumor stage. All malnutrition indexes were correlated with each other (CONUT vs. PNI, r = −0.657; CONUT vs. NRI scores, r = −0.672; PNI vs. NRI scores, r = 0.716, all P < 0.001). During a median follow-up of 43.1 months, 692 (46.32%) patients died. For patients malnourished, the incidence rate (events-per-1,000person-years) was as follows: CONUT (254.18), PNI (429.91), and NRI (261.87). Malnutrition was associated with increased risk for all-cause mortality (adjust HR [95%CI] for CONUT: 1.09 [1.05–1.13], P < 0.001; PNI: 0.98[0.97–0.99], P < 0.001; NRI: 0.98 [0.98–0.99], P < 0.001). All malnutrition indexes improved the predictive ability of the TNM classification system for all-cause mortality. Deterioration of nutritional status was associated with deterioration in Qol parameters and immunotherapeutic response (P < 0.001).

Conclusions: Malnutrition was prevalent in elderly patients with cancer, regardless of the assessment tools used, and associated with lower Qol and the immunotherapy response.
Application of Mass Spectrometry in Pancreatic Cancer Translational Research
Authors: Ge Peng , Luo Yalan , Chen Haiyang , Liu Jiayue , Guo Haoya , Xu Caiming , Qu Jialin , Zhang Guixin , Chen Hailong
Published: October 2021

Pancreatic cancer (PC) is one of the most common malignant tumors in the digestive tract worldwide, with increased morbidity and mortality. In recent years, with the development of surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, and the change of the medical thinking model, remarkable progress has been made in researching comprehensive diagnosis and treatment of PC. However, the present situation of diagnostic and treatment of PC is still unsatisfactory. There is an urgent need for academia to fully integrate the basic research and clinical data from PC to form a research model conducive to clinical translation and promote the proper treatment of PC. This paper summarized the translation progress of mass spectrometry (MS) in the pathogenesis, diagnosis, prognosis, and PC treatment to promote the basic research results of PC into clinical diagnosis and treatment.
Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
Authors: Zhang Li , Xu Zhongju , Jiang Tao , Zhang Jialu , Huang Pinxian , Tan Jiaqi , Chen Gan , Yuan Man , Li Zhuo , Liu Haibin , Gao Dengfeng , Xiao Lianbo , Feng Hui , Xu Jiatuo , Xu Hongxi
Published: October 2021

Equus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safety of Ejiao in blood-deficient patients. A total of 210 participants were recruited and randomly allocated into the placebo control group and Ejiao-treated group (6 g/day). The primary outcomes on the efficacy of Ejiao included traditional Chinese medicine symptom scores, blood indicators, and SF-36. The secondary outcomes were changes in fireness and safety evaluation. Results showed that Ejiao treatment for 8 weeks had significantly improved dizziness symptoms. Among the tested 24 blood biochemical parameters, the hematocrit and red blood cell numbers decreased in the placebo control group, but decreased significantly less in the Ejiao treatment group. The white blood cell and neutrophil counts increased in the Ejiao group but were within the normal range. In addition, the quality of life improved as the scores in SF-36 domains were significantly higher in the Ejiao group. At the same time, there was no significant change in the fire–heat symptoms score or other safety parameters. Considering all these, our study showed that Ejiao has a promising effect in women suffering from blood deficiency without obvious adverse effects.
Stomatal Lineage Control by Developmental Program and Environmental Cues
Authors: Han Soon-Ki , Kwak June M. , Qi Xingyun
Published: October 2021

Stomata are micropores that allow plants to breathe and play a critical role in photosynthesis and nutrient uptake by regulating gas exchange and transpiration. Stomatal development, therefore, is optimized for survival and growth of the plant despite variable environmental conditions. Signaling cascades and transcriptional networks that determine the birth, proliferation, and differentiation of a stomate have been identified. These networks ensure proper stomatal patterning, density, and polarity. Environmental cues also influence stomatal development. In this review, we highlight recent findings regarding the developmental program governing cell fate and dynamics of stomatal lineage cells at the cell state- or single-cell level. We also overview the control of stomatal development by environmental cues as well as developmental plasticity associated with stomatal function and physiology. Recent advances in our understanding of stomatal development will provide a route to improving photosynthesis and water-stress resilience of crop plants in the climate change we currently face.
Assessing Compassion in Korean Population: Psychometric Properties of the Korean Version of Sussex-Oxford Compassion Scales
Authors: Kim Jiyoung , Seo Jang-Won
Published: October 2021

A newly developed scale, the Sussex-Oxford Compassion Scale (SOCS) measures compassion for others and the self-based on an empirically supported five-elements definition of compassion: (a) recognizing suffering; (b) understanding the universality of suffering; (c) feeling for the person suffering; (d) tolerating uncomfortable feelings; and (e) motivation to act/acting to alleviate suffering. This study aimed to validate a Korean version of SOCS in a Korean adult sample. We administered the Sussex-Oxford Compassion Scale for Others (SOCS-O), the Sussex-Oxford Compassion Scale for the Self (SOCS-S), and other self-report measures of mindfulness, self-compassion, compassionate love, wellbeing, interpersonal reactivity, and mental health problems to analyze their psychometric properties. The findings support the five-factor hierarchical structure for the SOCS-O and SOCS-S, and as well as both scales’ adequate psychometric properties of measurement invariance, interpretability, internal consistency, floor/ceiling effects, and convergent/discriminant validity.
Individualizing Representational Similarity Analysis
Authors: Levine Seth M. , Schwarzbach Jens V.
Published: October 2021

Representational similarity analysis (RSA) is a popular multivariate analysis technique in cognitive neuroscience that uses functional neuroimaging to investigate the informational content encoded in brain activity. As RSA is increasingly being used to investigate more clinically-geared questions, the focus of such translational studies turns toward the importance of individual differences and their optimization within the experimental design. In this perspective, we focus on two design aspects: applying individual vs. averaged behavioral dissimilarity matrices to multiple participants' neuroimaging data and ensuring the congruency between tasks when measuring behavioral and neural representational spaces. Incorporating these methods permits the detection of individual differences in representational spaces and yields a better-defined transfer of information from representational spaces onto multivoxel patterns. Such design adaptations are prerequisites for optimal translation of RSA to the field of precision psychiatry.
“A Piece of Sanity in the Midst of Insane Times”: Girls on the Run Programming to Promote Physical Activity and Psychosocial Well-Being During the COVID-19 Pandemic
Authors: Weiss Maureen R. , Kipp Lindsay E. , Riley Allison
Published: October 2021

Afterschool programs have the potential to promote social, emotional, and physical health outcomes among youth participants. The positive youth development (PYD) framework argues that acquiring desirable attitudes and behaviors occurs when skill-building opportunities are explicitly provided within a safe and supportive climate guided by caring, competent, and compassionate instructors. Girls on the Run (GOTR) is a PYD program that uses running, motor skills, and other physical activities as a platform for promoting positive psychosocial outcomes and life skills learning among elementary- and middle school-aged girls. The onset of the COVID-19 pandemic challenged GOTR to modify lessons, coach training, and program delivery (in-person, virtual, or hybrid) to accommodate public health guidelines. The purpose of this study was to assess caregivers' and coaches' perceptions of program effectiveness in light of these changes. Following the Fall 2020 season, caregivers (n = 1,617) and coaches (n = 991) from 1,077 teams and 39 councils completed an online survey about program experiences. Both stakeholder groups positively rated program impact regardless of delivery mode, although in-person mode was rated higher for satisfaction with the end-of-season event. Thematic analysis of open-ended responses revealed that caregivers and coaches identified increased physical activity opportunities and life skills learning as well as improved social, psychological, and emotional development as a result of participating. Both stakeholders noted GOTR provided a sense of normalcy during this time of great need. Findings using mixed methods provide evidence of program effectiveness and recommendations for youth programming during challenging times.
South African Consumer Adoption of Plant-Based and Cultivated Meat: A Segmentation Study
Authors: Szejda Keri , Stumpe Moritz , Raal Ludwig , Tapscott Claire E.
Published: October 2021

The purpose of this study was to assess the likelihood of consumer adoption of plant-based and cultivated meat in South Africa as a pathway to a healthy, sustainable, and equitable food supply. We recruited a large sample of South Africans representative across age (18–61), gender, race, and income to participate in an online survey. Participants responded to a range of measures including adoption indicators, estimated yearly intake, motivators for purchasing, desired product characteristics, preferred species, and sociodemographics. We found a high degree of openness to both products. For plant-based meat, 67% were highly likely to try and 59% were highly likely to purchase. For cultivated meat, 60% were highly likely to try and 53% were highly likely to purchase. The highest acceptance was amongst the younger generations: 60% of born-frees, 62% of millennials, and 53% of Gen X were highly likely to purchase plant-based meat and 55% of born-frees, 55% of millennials, and 46% of Gen X were highly likely to purchase cultivated meat. For the general population, we observed that future meat intake was estimated to be split equally among the three meat categories (conventional, cultivated, and plant-based). We found early adopters (those highly likely to purchase) to be quite similar in attitudinal and sociodemographic characteristics in comparison to the general population. The study findings suggest that both plant-based and cultivated meat could be viable market-based options for improving the food system in South Africa, as consumers across all segments of society, and especially amongst the younger population, indicated broad acceptance.
Globally Optimizing QAOA Circuit Depth for Constrained Optimization Problems
Authors: Herrman Rebekah , Treffert Lorna , Ostrowski James , Lotshaw Phillip C. , Humble Travis S. , Siopsis George
Published: October 2021

We develop a global variable substitution method that reduces n-variable monomials in combinatorial optimization problems to equivalent instances with monomials in fewer variables. We apply this technique to 3-SAT and analyze the optimal quantum unitary circuit depth needed to solve the reduced problem using the quantum approximate optimization algorithm. For benchmark 3-SAT problems, we find that the upper bound of the unitary circuit depth is smaller when the problem is formulated as a product and uses the substitution method to decompose gates than when the problem is written in the linear formulation, which requires no decomposition.
Social Entrepreneurship Education: A Combination of Knowledge Exploitation and Exploration Processes
Authors: Ndou Valentina
Published: October 2021

It is widely accepted that entrepreneurship education has become a key development priority for coping with uncertainty and for addressing various social, economic, and technological concerns related to health, living conditions, education systems, employment, and economic growth. In recent times we have witnessed a proliferation of Entrepreneurship Education (EE) programs and initiatives with the aim to promote the creation of new skills, competencies, and capabilities to deal with a wide range of social issues and for creating new societal. The COVID-19 pandemic situation has introduced radical challenges to the society and has impacted significantly, especially the process of entrepreneurial competencies, skills and attitudes development. This paper aims to provide insights into knowledge mechanisms and learning strategies that have been activated for the effective creation of entrepreneurship competencies. We have based our evaluation on an exploratory analysis of 10 program studies that deliver social entrepreneurship education. The paper presents elements of originality under two perspectives: it proposes a framework with the main patterns characterizing social entrepreneurship education (SEE), and it argues that the creation of an entrepreneurship mindset and competencies is an evolutionary process that combines dynamic knowledge exploitation and exploration mechanisms.
Image Generation of Tomato Leaf Disease Identification Based on Adversarial-VAE
Authors: Wu Yang , Xu Lihong
Published: October 2021

The deep neural network-based method requires a lot of data for training. Aiming at the problem of a lack of training images in tomato leaf disease identification, an Adversarial-VAE network model for generating images of 10 tomato leaf diseases is proposed, which is used to expand the training set for training an identification model. First, an Adversarial-VAE model is designed to generate tomato leaf disease images. Then, a multi-scale residual learning module is used to replace single-size convolution kernels to enrich extracted features, and a dense connection strategy is integrated into the Adversarial-VAE networks to further enhance the image generation ability. The training set is expanded by the proposed model, which generates the same number of images by training 10,892 images of 10 leaves. The generated images are superior to those of InfoGAN, WAE, VAE, and VAE-GAN measured by the Frechet Inception Distance (FID). The experimental results show that using the extension dataset that is generated by the Adversarial-VAE model to train the Resnet identification model could improve the accuracy of identification effectively. The model proposed in this paper could generate enough images of tomato leaf diseases and provide a feasible solution for data expansion of tomato leaf disease images.
Irrigation Induced Salinity and Sodicity Hazards on Soil and Groundwater: An Overview of Its Causes, Impacts and Mitigation Strategies
Authors: Mohanavelu Aadhityaa , Naganna Sujay Raghavendra , Al-Ansari Nadhir
Published: October 2021

Salinity and sodicity have been a major environmental hazard of the past century since more than 25% of the total land and 33% of the irrigated land globally are affected by salinity and sodicity. Adverse effects of soil salinity and sodicity include inhibited crop growth, waterlogging issues, groundwater contamination, loss in soil fertility and other associated secondary impacts on dependent ecosystems. Salinity and sodicity also have an enormous impact on food security since a substantial portion of the world’s irrigated land is affected by them. While the intrinsic nature of the soil could cause soil salinity and sodicity, in developing countries, they are also primarily caused by unsustainable irrigation practices, such as using high volumes of fertilizers, irrigating with saline/sodic water and lack of adequate drainage facilities to drain surplus irrigated water. This has also caused irreversible groundwater contamination in many regions. Although several remediation techniques have been developed, comprehensive land reclamation still remains challenging and is often time and resource inefficient. Mitigating the risk of salinity and sodicity while continuing to irrigate the land, for example, by growing salt-resistant crops such as halophytes together with regular crops or creating artificial drainage appears to be the most practical solution as farmers cannot halt irrigation. The purpose of this review is to highlight the global prevalence of salinity and sodicity in irrigated areas, highlight their spatiotemporal variability and causes, document the effects of irrigation induced salinity and sodicity on physicochemical properties of soil and groundwater, and discuss practical, innovative, and feasible practices and solutions to mitigate the salinity and sodicity hazards on soil and groundwater.
Optimization and Experiment of Straw Back-Throwing Device of No-Tillage Drill Using Multi-Objective QPSO Algorithm
Authors: Xu Hongbo , Hu Zhichao , Zhang Peng , Gu Fengwei , Wu Feng , Song Wanli , Wang Chunci
Published: October 2021

Reducing operation energy consumption is the development demand of conservation tillage equipment. In order to solve the problems of high power consumption and the easy blockage of the no-tillage drill under full straw retention, the key parameters of the straw back-throwing device were optimized in this study. The Box–Behnken central combination test method was used to analyze the influence of the impeller rotating speed, feed quantity and cross-sectional area of the throwing pipe on the specific power consumption and throwing speed, the mathematical models of which were built with the aid of the least square method. In addition, the mathematical models were optimized by using a multi-objective quantum behaved particle swarm optimization (QPSO) with an improved target weighting coefficient. The optimization results indicated that, when the impeller rotating speed was 2287 r/min, the feed quantity was 1.1 kg/s and the cross-sectional area of the throwing pipe was 506.997 cm2, the specific power consumption and throwing speed by the models were 7528 m2/s2 and 11.73 m/s, respectively. The models were verified by comparing the optimization results with the measured data in the simulation filed tests, which proved that the multi-objective QPSO algorithm was feasible to optimize the working and structural parameters of the straw back-throwing device of the no-tillage drill under full straw retention. The results provide references for the parameter optimization of similar no-tillage drills under straw retention.
The Productivity of Cassava (Manihot esculenta Crantz) in Kagoshima, Japan, Which Belongs to the Temperate Zone
Authors: Yabuta Shin , Fukuta Tamami , Tamaru Shotaro , Goto Keita , Nakao Yoshihiro , Khanthavong Phanthasin , Ssenyonga Peter , Sakagami Jun-Ichi
Published: October 2021

The cultivation period of cassava in Kagoshima, Japan, which belongs to the temperate zone, is limited by the low temperature in winter. To maximize productivity under this limited period, investigations were conducted on the gas exchange rate and production structure relating to light utilization in a plant community of cassava grown under different nitrogen fertilization conditions. Fertilization either at planting or three months after planting significantly increased stomatal conductance in the upper canopy and root dry weight compared to the control. In addition, the dry matter distribution to stem and root dry matter rate of initial fertilization treatment were significantly higher, and the dry matter distribution to root of the latter fertilization treatment tended to be higher than that of the control. However, light transmittance at 80 cm below the top of the canopy was almost the same as that at the ground surface, which was a common tendency among the treatments. In conclusion, it was revealed that the effects of fertilization on yield were mainly the increase in the gas exchange rate of individual leaves and the change of dry matter distribution rather than an improvement in light transmittance.
Comparative Assessment of Effectiveness of Alternative Genotyping Assays for Characterizing Carotenoids Accumulation in Tropical Maize Inbred Lines
Authors: Sayadi Maazou Abdoul-Raouf , Gedil Melaku , Adetimirin Victor O. , Meseka Silvestro , Mengesha Wende , Babalola Deborah , Offornedo Queen Nkem , Menkir Abebe
Published: October 2021

The development of maize varieties with increased concentration of Provitamin A (PVA) is an effective and affordable strategy to combat vitamin A deficiency in developing nations. However, the considerably high cost of carotene analysis poses a major challenge for maize PVA biofortification, prompting the use of marker-assisted selection. Presently, two types of genotyping with PVA trait-linked functional markers have been developed and extensively used in breeding programs. The two systems are low throughput gel-based genotyping and genotyping with Kompetitive Allele-Specific PCR (KASP) single nucleotide polymorphism (SNPs) markers. Although the KASP SNPs genotyping was developed to replace the gel-based genotyping, studies have not been conducted to compare the effectiveness of the KASP SNPs markers with the gel-based markers. This study was conducted to assess the carotenoid content of 64 tropical PVA biofortified maize inbred lines containing temperate germplasm in their genetic backgrounds and screen them with both gel-based and KASP markers of PSY1, LCYE and crtRB1 genes. Many of the 64 inbred lines had PVA concentrations surpassing the 15 µg/g provitamin A breeding target set by the HarvestPlus Challenge Program. Favorable alleles of crtRB1, crtRB1 and the KASP SNPs markers were detected in 25 inbred lines with high PVA concentrations. Inbred lines with the favorable alleles of LCYE had the highest concentrations of non-PVA carotenoids, whereas those with the favorable alleles of crtRB1 had high levels of PVA carotenoids. Data from the sequenced region of LCYE revealed one SNP in the first intron that clearly differentiated the high and low β-carotene maize inbred lines. The results of our study demonstrate that the automated KASP SNPs markers can replace the gel-based genotyping for screening a large number of early generation maize inbred lines for PVA content.
Spatial Distribution of Available Trace Metals in Four Typical Mediterranean Soils: The Caia Irrigation Perimeter Case Study
Authors: Telo da Gama José , Loures Luis , López-Piñeiro António , Nunes José Rato
Published: October 2021

There is a small sample of edaphic geochemistry studies over large geographic areas, especially studies that consider major reference soil groups (RSG) that evaluate both native concentrations of elements and anthropogenically contaminated soils in agricultural settings, considering the long-term effect of agricultural practices on landscape sustainability. In this study, four RSGs were analyzed for the available trace elements Ni, Cr, Cd, Pb, Cu, Mn, and Zn, including other edaphic properties from 2002 to 2012. The main objectives were to assess the range of concentrations of the selected elements in the four typical Mediterranean soils, Cambisols, Luvisols, Calcisols, and Fluvisols, with heavy anthropogenic input (HAI) and compare them to minimal anthropogenic input (MAI). For MAI, the background levels of Pb, Ni, Cd, and Cr were highest in Calcisols, differing from those of Cambisols, Luvisols, and Fluvisols (p < 0.01), Cu is highest both in Calcisols and Luvisols while Mn is higher in Cambisols and Fluvisols (p < 0.05). The background concentration of Zn was the same in all RSGs (p > 0.05). For HAI, the reference levels of Pb, Ni, Cd, Mn, and Cr were highest in the Calcisols, and Cu was high in all RSGs except Fluvisols, while Zn presented the lowest concentrations in the Luvisol RSG, with all these results considering a confidence interval of 95%. Predictive maps for the sampled elements, as well as the edaphic bioavailability, are provided. This environmental impact assessment suggests that the land use is departing from sustainable ecosystem service development and that territorial management practices, with conservation goals in mind, should be adopted.