bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Calcium Chloride Crosslinking Solution Concentration on the Long-Term Cell Viability of 16HBE14o- Human Bronchial Cells Embedded in Alginate-Based Hydrogels
Authors: Wood Nathan , Doria Esther I. , Rahman Taieba Tuba , Li Wanhe , Pei Zhijian , Qin Hongmin
Published: January 2025

In this preliminary study, the long-term effects of calcium chloride crosslinking concentration on viability of 16HBE14o- human bronchial epithelial cells embedded in alginate-extracellular matrix (ECM) or alginate–methylcellulose–ECM hydrogels have been investigated. There is currently a limited understanding regarding the effects of crosslinking solution concentration on lung epithelial cells embedded in hydrogel. Furthermore, the effects of calcium chloride concentration in crosslinking solutions on other cell types have not been reported regarding whether the addition of viscosity and stiffness tuning agents such as methylcellulose will alter the responses of cells to changes in calcium chloride concentration in crosslinking solutions. While there were no significant effects of calcium chloride concentration on cell viability in alginate–ECM hydrogels, there is a decrease in cell viability in alginate–methylcellulose–ECM hydrogels crosslinked with 300 mM calcium chloride crosslinking solution. These findings have implications in the maintenance of 16HBE14o- 3D cultures with respect to the gelation of alginate with high concentrations of ionic crosslinking solution.
Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning
Authors: Batzikosta Areti , Moraitou Despina , Steiropoulos Paschalis , Papantoniou Georgia , Kougioumtzis Georgios A. , Katsouri Ioanna-Giannoula , Sofologi Maria , Tsolaki Magda
Published: January 2025

Background/Objectives: The study examined the relationships between specific Theory-of-Mind (ToM) dimensions, cognitive planning, and sleep duration in aging adults. Methods: The sample included 179 participants, comprising 46 cognitively healthy individuals, 75 diagnosed with amnestic Mild Cognitive Impairment (aMCI), and 58 with non-amnestic (naMCI). The mean age of the participants was 70.23 years (SD = 4.74), with a mean educational attainment of 12.35 years (SD = 3.22) and gender distribution of 53 men and 126 women. ToM assessment included tasks measuring the understanding and interpretation of non-literal speech, proverbs and metaphors, as well as an emotion-recognition test. For cognitive planning, a Tower Test was utilized. Sleep duration was measured using actigraphy. Results: We identified significant differences in various ToM tasks’ performance between the groups, particularly in non-literal speech tasks and third-order ToM stories. The HC group consistently outperformed both MCI groups in these tasks, with aMCI showing higher performance than naMCI. Mediation analysis applied to examine potential direct and indirect effects of sleep duration on ToM tasks indicated that total sleep time had significant indirect effects through cognitive planning—mainly as rule violation total score—on specific ToM aspects. Hence, besides the effects of MCI pathologies and especially of naMCI, sleep duration seems also to be associated with ToM performance in aging via specific executive functioning decrements. Conclusions: The findings underscore the social implications of ToM deficits due to MCI and/or sleep duration decrease, particularly in naMCI older adults, as they can seriously impair their social interactions. Targeted interventions could improve emotional understanding, communication, and overall quality of life.
Parametric Analysis of Steel Studs to Reduce Thermal Bridges in Light Steel Framing Construction Systems
Authors: Langner Marcelo , Soares Thais A. , Figueiredo António , Almeida Ricardo M. S. F. , Vicente Romeu
Published: January 2025

Thermal bridges significantly affect the thermal performance of light steel framing systems due to the high thermal conductivity of steel. The objective of this study is to identify modifications on the steel profiles to reduce heat flux and improve the thermal resistance of both single- and double-layer wall panels. Three approaches were analyzed: (i) slotted steel studs, (ii) integration of less-conductive materials into the web section, and (iii) modifications to web geometry. A numerical model was calibrated based on experimental data and used to perform dynamic simulations with different configurations. Results show that incorporating less-conductive materials, such as rigid polyamide, achieved a heat flux reduction of up to 98%, while optimized slotted patterns reduced heat flux by up to 90%. The results also demonstrated that all web modifications effectively reduced heat flux through the wall, with approaches (i) and (ii) showing the greatest impact. The shape of the slots also has an important impact on the heat flux. The most effective strategy for enhancing the thermal performance of the steel studs was the use of a less-conductive material.
Vibration-Based Damage Prediction in Composite Concrete–Steel Structures Using Finite Elements
Authors: Cedeño-Rodríguez Mario D. , Yanez Sergio J. , Saavedra-Flores Erick I. , Guzmán Carlos Felipe , Pina Juan Carlos
Published: January 2025

The prediction of structural damage through vibrational analysis is a critical task in the field of composite structures. Structural defects and damage can negatively influence the load-carrying capacity of the beam. Therefore, detecting structural damage early is essential to preventing catastrophic failures. This study addresses the challenge of predicting damage in composite concrete–steel beams using a vibration-based finite element approach. To tackle this complex task, a finite element model to a quasi-static analysis emulating a four-point pure bending experimental test was performed. Notably, the numerical model equations were carefully modified using the Newton–Raphson method to account for the stiffness degradation resulting from material strains. These modified equations were subsequently employed in a modal analysis to compute modal shapes and natural frequencies corresponding to the stressed state. The difference between initial and damaged modal shape curvatures served as the foundation for predicting a damage index. The approach effectively captured stiffness degradation in the model, leading to observable changes in modal responses, including a reduction in natural frequencies and variations in modal shapes. This enabled the accurate prediction of damage instances during construction, service, or accidental load scenarios, thereby enhancing the structural and operational safety of composite system designs. This research contributes to the advancement of vibration-based methods for damage detection, emphasizing the complexities in characterizing damage in composite structural geometries. Further exploration and refinement of this approach are essential for the precise classification of damage types.
Immune Gene Expression Profiling in Individuals with Turner Syndrome, Graves’ Disease, and a Healthy Female by Single-Cell RNA Sequencing: A Comparative Study
Authors: Sim Soo Yeun , Baek In-Cheol , Cho Won Kyoung , Jung Min Ho , Kim Tai-Gyu , Suh Byung-Kyu
Published: January 2025

Turner syndrome (TS) can be determined by karyotype analysis, marked by the loss of one X chromosome in females. However, the genes involved in autoimmunity in TS patients remain unclear. In this study, we aimed to analyze differences in immune gene expression between a patient with TS, a healthy female, and a female patient with Graves’ disease using single-cell RNA sequencing (scRNA-seq) analysis of antigen-specific CD4(+) T cells. We identified 43 differentially expressed genes in the TS patient compared with the healthy female and the female patient with Graves’ disease. Many of these genes have previously been suggested to play a role in immune system regulation. This study provides valuable insights into the differences in immune-related gene expression between TS patients, healthy individuals, and those with autoimmune diseases.
Comparative Assessment of Biomass and Power-to-Gas Processes Integrated with Different Electricity-Driven Gasification Technologies
Authors: Song Guohui , Cui Xiaobo , Wang Liang , Wei Zheng
Published: January 2025

To develop a biomass and power-to-gas (BPtG) process for renewable electricity storage and sustainable synthetic natural gas (SNG) production, this work investigated five BPtG processes integrated with different electricity-driven gasification technologies based on simulation data. These processes were evaluated for SNG composition and yield, life-cycle energy and exergy efficiencies, life-cycle carbon emissions, and the equivalent unit production cost. The results show that the energy and exergy efficiencies of SNG from those processes range between 53.1 and 58.6% and 36.4 and 41.1%, respectively. Based on the energy allocation method, the carbon emissions without and with CO2 capture ranges from 22.0 to 34.8 and from −43.4 to −17.6, respectively, in gCO2e/MJSNG. These BPtG processes can produce low-carbon SNG and even achieve negative carbon emissions with CO2 capture. Both feedstock and electricity costs have significant influences on the profitability of the processes. The BPtG process integrated with resistance heating gasification, plasma-assisted gasification, and moderate water electrolysis are recommended for their compromise of multi-perspective performances. This paper provided the orders of the five processes based on these indicators and recommendations for different applicable scenarios.
Probing Functional Thin Films with Grazing Incidence X-Ray Scattering: The Power of Indexing
Authors: Smilgies Detlef-M.
Published: January 2025

Grazing incidence small- and wide-angle X-ray scattering (GISAXS, GIWAXS) has been widely applied for the study of functional thin films, be it for the characterization of nanostructured morphologies in block copolymers, nanocomposites, and nanoparticle assemblies, or for the packing and orientation of aromatic molecules or conjugated polymers. Solution-processed thin films are typically uniaxial powders, with a specific crystallographic plane oriented parallel to the substrate surface while ordered domains assume random orientations laterally. The convenient GISAXS/GIWAXS scattering geometry facilitates obtaining complete information about thin film structure as well as the ability to study samples in well-defined sample environments, as controlled by temperature, exposure to solvent vapor and drying, or coating processes. Moreover, with suitable X-ray sources and detectors, information about the ordering kinetics and phase transitions can be obtained down to the millisecond scale. The scattering geometry and an interactive graphical tool to index such scattering patterns will be discussed here. Furthermore, it will be demonstrated that proper indexing of the X-ray scattering patterns can provide deep insight into thin film structure–property relationships and the kinetics of structure formation. Recent examples of nanostructures and molecular organization in thin films will be discussed, as well as self-assembly processes leading to such structures.
Unified Analysis of Viscoelasticity and Viscoplasticity Using the Onsager Variational Principle
Authors: Cho Kwang Soo
Published: January 2025

This study is the application of the Onsager variational principle to viscoelasticity and viscoplasticity with the minimization of the assumptions which are popularly used in conventional approaches. The conventional approaches assume Kröner–Lee decomposition, incompressible plastic deformation, flowing rule, stress equation and so on. These assumptions have been accumulated by many researchers for a long time and have shown many successful cases. The large number of successful assumptions leads to the conjecture that the mechanics can be described with a smaller number of assumptions. This paper shows that this conjecture is correct by using the Onsager variational principle.
Affective Computing for Learning in Education: A Systematic Review and Bibliometric Analysis
Authors: Yuvaraj Rajamanickam , Mittal Rakshit , Prince A. Amalin , Huang Jun Song
Published: January 2025

Affective computing is an emerging area of education research and has the potential to enhance educational outcomes. Despite the growing number of literature studies, there are still deficiencies and gaps in the domain of affective computing in education. In this study, we systematically review affective computing in the education domain. Methods: We queried four well-known research databases, namely the Web of Science Core Collection, IEEE Xplore, ACM Digital Library, and PubMed, using specific keywords for papers published between January 2010 and July 2023. Various relevant data items are extracted and classified based on a set of 15 extensive research questions. Following the PRISMA 2020 guidelines, a total of 175 studies were selected and reviewed in this work from among 3102 articles screened. The data show an increasing trend in publications within this domain. The most common research purpose involves designing emotion recognition/expression systems. Conventional textual questionnaires remain the most popular channels for affective measurement. Classrooms are identified as the primary research environments; the largest research sample group is university students. Learning domains are mainly associated with science, technology, engineering, and mathematics (STEM) courses. The bibliometric analysis reveals that most publications are affiliated with the USA. The studies are primarily published in journals, with the majority appearing in the Frontiers in Psychology journal. Research gaps, challenges, and potential directions for future research are explored. This review synthesizes current knowledge regarding the application of affective computing in the education sector. This knowledge is useful for future directions to help educational researchers, policymakers, and practitioners deploy affective computing technology to broaden educational practices.
Simulation and Economic Benefit Analysis of Carburetor Combined Transport in Winter at a Liquefied Natural Gas Receiving Station
Authors: Cao Song , Luan Tao , Zuo Pengliang , Si Xiaolei , Xie Pu , Guo Yingjun
Published: January 2025

In the winter, a certain LNG receiving terminal operates exclusively with the submerged combustion vaporizer (SCV). However, due to the high operational costs associated with the SCV, a new combined operation scheme utilizing both the SCV and the open rack vaporizer (ORV) has been proposed. First, models for the SCV and ORV gasification units were developed in Aspen HYSYS and validated using actual operational parameters. Next, the relationship between the seawater inlet–outlet temperature difference and the minimum seawater flow rate for the ORV was determined, and an optimized seawater pump operation strategy, considering LNG export volumes, was formulated. Additionally, the relationship between the SCV fuel gas flow rate and LNG export volume was analyzed, and a comparison was made between the operating costs of SCV running independently and the combined SCV-ORV operation under winter conditions. The results of the combined operation experiments indicated that at a seawater inlet–outlet temperature difference of 3 °C, the joint operation mode could save costs by 70–77%; at 2.5 °C difference, it saves 60–67%; at 2 °C difference, it saves 45–50%; at 1.5 °C difference, it saves 35–38%; and at 1 °C difference, it saves 20–23%. This approach achieves optimized economic performance for LNG terminal operations.
Functional Involvement of Melatonin and Its Receptors in Reproductive Regulation of the Marine Teleost, Large Yellow Croaker (Larimichthys crocea)
Authors: Liang Xudong , Wang Jixiu , Huang Baoyi , Yuan Haojie , Ren Yucheng , Wu Chenqian , Wang Tianming , Yang Jingwen
Published: January 2025

Melatonin is a critical regulator of biological rhythms across organisms, transducing light signals into neuroendocrine signals that facilitate reproductive regulation in response to environmental cues. However, the precise mechanisms through which melatonin regulates reproduction in fish require further investigation. In this study, we employed molecular and organizational biological techniques to examine the expression patterns of melatonin and its five receptor subtypes (LcMTNR1A1, LcMTNR1A2, LcMTNR1B1, LcMTNR1B2, and LcMTNR1C) in various tissues of the large yellow croaker (Larimichthys crocea). Our results revealed significant expression of all receptors in the pituitary and testes, with distinct gender differences, including a lack of expression in the ovary. Moreover, our data indicate that melatonin and its receptors are primarily expressed during stage III, highlighting their role in sexual maturity. Enzyme- linked immunosorbent assay (ELISA) results further demonstrated that in vitro melatonin incubation in the brain of L. crocea influenced gonadotropin-releasing hormone (GnRH) and testosterone secretion in a dose-dependent manner, suggesting actions beyond the classical hypothalamic–pituitary–gonadal (HPG) axis. Overall, our findings provide new evidence supporting the role of the melatonin system in reproductive regulation in marine teleosts.
Tamarind (Tamarindus indica L.) Components as a Sustainable Replacement for Pork Meat in Frankfurter Sausages
Authors: Passos Rafael Sepúlveda F. Trevisan , de Sousa Camila Cristina A. , da Silva Mauricio C. A. , Herrero Ana M. , Ruiz-Capillas Claudia , Cavalheiro Carlos Pasqualin
Published: January 2025

Five types of frankfurters were formulated: a control without tamarind (T0) and four samples using 5% tamarind pulp paste (PT5), seeds (ST5), peel (CT5), and a blend of all of them (PSCT5), replacing the same portion of meat. The inclusion of tamarind components led to a reduction in the moisture and protein content of the reformulated frankfurters. In terms of mineral composition, CT5 showed the highest (p < 0.05) calcium content. Additionally, ST5 and CT5 treatments demonstrated the lowest processing loss values. The pH was lower in the PT5 treatment (p < 0.05). Incorporating tamarind components reduced the lightness (L*) of the frankfurters, resulting in darker sausages. However, ST5 exhibited greater redness (a*), while higher yellowness (b*) values were observed in PT5 and CT5 treatments (p < 0.05). Texture analysis revealed no differences (p > 0.05) in hardness and chewiness between T0 and PT5; however, ST5 exhibited the highest values for these parameters (p < 0.05). No variation in the conformational order of the lipid acyl chains due to the incorporation of tamarind compounds was observed related to physical entrapment of these compounds in the frankfurter matrix. Both T0 and PT5 were well accepted by consumers, and scores higher than 7 were observed for overall acceptability and purchase intention. The study demonstrated that incorporating tamarind components, especially pulp paste (PT), is a viable alternative for replacing lean pork meat in frankfurters, improving the sustainable aspects of frankfurter production.
Development of an Operational Map for the 3D Printing of Phytosterol-Enriched Oleogels: Rheological Insights and Applications in Nutraceutical Design
Authors: De Salvo María Itatí , Palla Camila , Cotabarren Ivana M.
Published: January 2025

Three-dimensional (3D) printing attracts significant interest in the food industry for its ability to create complex structures and customize nutritional content. Printing materials, or inks, are specially formulated for food or nutraceuticals. These inks must exhibit proper rheological properties to flow smoothly during printing and form stable final structures. This study evaluates the relationship between rheological properties and printability in phytosterol-enriched monoglyceride (MG) oleogel-based inks, intended for nutraceutical applications. Key rheological factors, including gelation temperature (Tg), elastic (G′) and viscous (G″) modulus, and viscosity (µ) behavior with shear rate (γ˙), were analyzed for their impact on flow behavior and post-extrusion stability. Furthermore, this study allowed the development of an operation map to predict successful printing based on material µ and Tg. Oleogels (OGs) were prepared with high-oleic sunflower oil (HOSO) and 10 wt% MG, enriched with phytosterols (PSs) at concentrations between 0 and 40 wt%. While higher PS content generally led to an increase in both Tg and µ, the 10 wt% PS mixture exhibited a different behavior, showing lower Tg and µ compared to the 0 wt% and 5 wt% PS mixtures. The optimal PS concentration was identified as 20 wt%, which exhibited optimal properties for 3D printing, with a Tg of 78.37 °C and µ values ranging from 0.013 to 0.032 Pa.s that yielded excellent flowability and adequate G′ (3.07 × 106 Pa) at room temperature for self-supporting capability. These characteristics, visualized on the operational map, suggest that 20% PS OGs meet ideal criteria for successful extrusion and layered deposition in 3D printing.
Short-Time High-Oxygen Pre-Treatment Delays Lignification of Loquat (Eriobotrya japonica Lindl.) During Low-Temperature Storage
Authors: Kou Runlei , Peng Mengfei , Zheng Jiaxuan , Hou Shuangdi , Ma Linyuan , Liu Xia
Published: January 2025

Lignification often occurs during low-temperature storage in loquat fruit, leading to increased firmness and lignin content, water loss, and changes in flavor. As induced stress factors, short-time high-oxygen pre-treatment (SHOP) can initiate resistant metabolism and regulate the physicochemical qualities during fresh fruit storage. However, the effect of SHOP on the lignification and quality of loquat has been reported less. In the present study, loquat fruit was immersed in oxygen concentrations of 70%, 80%, and 90% for 30 min before being stored at 4 ± 1 °C. The results showed that the 80% SHOP samples had lower lignin accumulation and firmness, showing reductions of 23.1% and 21.1% compared to the control at 50 days. These effects were associated with the inhibition of the activities of lignin synthesis-related enzymes, including phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4CL), cinnamyl alcohol dehydrogenase (CAD), and peroxidase (POD). Meanwhile, 80% SHOP improved the antioxidant enzyme system and maintained the structural integrity of the cells. Furthermore, SHOP retained the color and suppressed decay and weight loss and the decline in the soluble solids content (SSC) and titratable acidity (TA). As a convenient and cheap physical approach, SHOP is a promising technology for delaying lignification by regulating lignin synthesis in loquat storage.
Synchronization in Public Transportation: A Review of Challenges and Techniques
Authors: Kapica Daniel , Melnikova Yulia , Naumov Vitalii
Published: January 2025

Performing synchronization in public transport is one of the most challenging tasks that transport managers perform when organizing the processes of passenger servicing. Many variables characterizing existing public transport lines should be considered in the final timetable; in addition, the complexity of the transportation system, the variability in transport demand, and the stochasticity of the servicing process both in time and space have a significant influence on the result of synchronization. The synchronization problem in real-world applications does not have an exact solution, so in practice, a variety of techniques were developed to achieve a rational solution in a reasonable time. In our paper, we classify existing approaches to solving the problem of public transport synchronization, describe the essence of the most promising methods, and study their popularity based on the most recent scientific publications. As the result of our research, we show the most promising directions for the future development of synchronization methods and their application in public transportation.
A Review of Long-Lasting Activities of the Central Engine of Gamma-Ray Bursts
Authors: Gendre Bruce
Published: January 2025

Gamma-ray bursts are known to display various features on top of their canonical behavior. In this short review, we will describe and discuss two of them: the ultra-long gamma-ray bursts, which are defined by an extreme duration of their prompt phase, and the plateau phase, which is defined by a steady phase of large duration at the start of the afterglow. We will review the main properties of those two phenomena, and will discuss their possible origin, in light of the standard fireball model of gamma-ray bursts. A final section will discuss the future missions, which could bring new evidence to the study of those objects.
The Beneficial Role of Polysaccharide Hydrocolloids in Meat Products: A Review
Authors: Bao Hanxiao , Wang Yuxi , Huang Yue , Zhang Yuhao , Dai Hongjie
Published: January 2025

Polysaccharide hydrocolloids have garnered increasing attention from consumers, experts, and food processing industries due to their advantages of abundant resources, favorable thickening properties, emulsification stability, biocompatibility, biodegradability, and high acceptance as food additives. This review focuses on the application of polysaccharide hydrocolloids and their beneficial roles in meat products by focusing on several commonly used polysaccharides (i.e., cellulose, chitosan, starch, sodium alginate, pectin, and carrageenan). Firstly, the recent advancements of polysaccharide hydrocolloids used in meat products are briefly introduced, along with their structure and potential application prospects. Then, the beneficial roles of polysaccharide hydrocolloids in meat products are comprehensively summarized and highlighted, including retarding lipid and protein oxidation, enhancing nutritional properties, improving texture and color quality, providing antibacterial activity, monitoring freshness, acting as a cryoprotectant, improving printability, and ensuring security. Finally, the challenges and opportunities of polysaccharide hydrocolloids in meat products are also introduced.
Examining Deep Learning Pixel-Based Classification Algorithms for Mapping Weed Canopy Cover in Wheat Production Using Drone Data
Authors: Oppong Judith N. , Akumu Clement E. , Dennis Samuel , Anyanwu Stephanie
Published: January 2025

Deep learning models offer valuable insights by leveraging large datasets, enabling precise and strategic decision-making essential for modern agriculture. Despite their potential, limited research has focused on the performance of pixel-based deep learning algorithms for detecting and mapping weed canopy cover. This study aims to evaluate the effectiveness of three neural network architectures—U-Net, DeepLabV3 (DLV3), and pyramid scene parsing network (PSPNet)—in mapping weed canopy cover in winter wheat. Drone data collected at the jointing and booting growth stages of winter wheat were used for the analysis. A supervised deep learning pixel classification methodology was adopted, and the models were tested on broadleaved weed species, winter wheat, and other weed species. The results show that PSPNet outperformed both U-Net and DLV3 in classification performance, with PSPNet achieving the highest overall mapping accuracy of 80%, followed by U-Net at 75% and DLV3 at 56.5%. These findings highlight the potential of pixel-based deep learning algorithms to enhance weed canopy mapping, enabling farmers to make more informed, site-specific weed management decisions, ultimately improving production and promoting sustainable agricultural practices.
On the Ionosphere–Atmosphere–Lithosphere Coupling During the 9 November 2022 Italian Earthquake
Authors: Piersanti Mirko , D’Angelo Giulia , Recchiuti Dario , Lepreti Fabio , Cusano Paola , De Lauro Enza , Carbone Vincenzo , Ubertini Pietro , Falanga Mariarosaria
Published: January 2025

In the last decades, the scientific community has been focused on searching earthquake signatures in the Earth’s atmosphere, ionosphere, and magnetosphere. This work investigates an offshore Mw 5.5 earthquake that struck off the Marche region’s coast (Italy) on 9 November 2022, with a focus on the potential coupling between the Earth’s lithosphere, atmosphere, and magnetosphere triggered by the seismic event. Analysis of atmospheric temperature data from ERA5 reveals a significant increase in potential energy (Ep) at the earthquake’s epicenter, consistent with the generation of Atmospheric Gravity Waves (AGWs). This finding is further corroborated by the MILC analytical model, which accurately simulates the observed Ep trends (within 5%), supporting the theory of Lithosphere–Atmosphere–Ionosphere–Magnetosphere coupling. The study also examines the vertical Total Electron Content (vTEC) and finds notable fluctuations at the epicenter, exhibiting periodicities (7–12 min) characteristic of AGWs and traveling ionospheric disturbances. The correlation between ERA5 observations and MILC model predictions, particularly in temperature deviations and Ep distributions, strengthens the hypothesis that earthquake-generated AGWs impact atmospheric conditions at high altitudes, leading to observable ionospheric perturbations. This research contributes to a deeper understanding of Lithosphere–Atmosphere–Ionosphere–Magnetosphere coupling mechanisms and the potential for developing reliable earthquake prediction tools.
What Makes a Quality Lifestyle Coach? A Theoretical Model Based on the Real-World Context of Delivering the National Diabetes Prevention Program
Authors: Madrigal Lillian H. , Manders Olivia C. , Kadir Mumta , Piper Sarah A. , Weber Mary Beth , Blais Linelle M.
Published: January 2025

Background/Objectives: Lifestyle coaches are integral to delivery of the National Diabetes Prevention Program (DPP); however, few studies have explored the role of the lifestyle coach in relation to participant success. This study aimed to develop a conceptual model of the factors that contribute to lifestyle coach performance and success. Methods: A cross-sectional qualitative study including 82 semi-structured interviews with National DPP staff and participants between June 2020 and February 2022. Results: Based on the analysis of the interviews, the developed model illustrates how central to coach success are the intrinsic qualities they bring to the role, the quality of their training and preparation for the lifestyle coach role, and the mechanization of their qualities and training through their program delivery. Around this focal relationship revolve four other factors that together or independently affect lifestyle coach success: organization influences; external influences; program participants; and evaluation and feedback. Conclusions: Health coaching can be an incredibly powerful tool in behavior change. This model provides insight into how coaching can impact participant outcomes and can be used by other health promotion programs who use the coach model.
Cardiac Contractility Modulation Therapy in a Transplant Candidate Patient with Advanced Heart Failure to Improve Cardiac Function and Restore Sinus Rhythm
Authors: Rodio Giovanna , Ludovico Marilisa , Angelini Alessio , Alfeo Maria , Andrenucci Dennis , Pugliese Giovanni , Luvera Walter , Luzzi Giovanni
Published: January 2025

Cardiac Contractility Modulation (CCM) is an electrical therapy based on an implantable device. This device is approved for patients with heart failure with reduced ejection fraction (HFrEF). Randomized clinical trials and thousands of described cases and studies have shown how CCM can improve exercise tolerance, quality of life, re-hospitalization for HF, and cardiac function by reverse left ventricular modelling. In this case report, we describe a patient candidate for a cardiac transplant based on dilated cardiomyopathy with severe LV dysfunction and narrow QRS. The patient had frequent heart failure-related hospitalizations, despite the optimal medical therapy. The strategy was to adopt the Cardiac Contractility Modulation (CCM) therapy while waiting for a cardiac transplant. During a consultation on all prospective therapy options, the patient refused the LVAD therapy, and was more confident in adopting a less invasive device therapy like CCM. This strategy had a very fast and beneficial impact on the patient’s health; the CCM improved heart failure symptoms, hemodynamics flow and cardiac functionality. Moreover, after a relatively short time, the patient went from persistent AF to Sinus Rhythm, although he started with a severe bi-atrial dilatation. These parameters were stable during an extended follow-up of 18 months.
Design and Construction of the Real Felipe Fortress of Callao: Analysis of the Military Treatise and Layout Using Photogrammetry and GIS
Authors: Celis-Estrada Diego Javier , Rodriguez-Navarro Pablo , Gil-Piqueras Teresa
Published: January 2025

Peru constituted the most important Viceroyalty of the Spanish Empire in South America, with the Port of Callao controlling the South Pacific trade routes. Although it was safe in its infancy, Callao suffered coastal attacks leading to its fortification. However, on 28 October 1746, an earthquake and tidal wave devastated the port, leading to its relocation and the construction of the Real Felipe Fortress of Callao, the South Pacific’s most significant fortification. The fortress was based on 18th century military conceptions adapted to the specific conditions of the coastal lands of the Peruvian Viceroyalty, such as the lack of stone, the use of adobe, and the frequent earthquakes. This research sought to identify the architectural theories influencing its design, the adaptations necessary for its coastal location, and the underlying mathematical and military concepts. Photogrammetry based techniques and a geographic information system (GIS) were used for georeferencing historical planimetry, along with the analysis of historical documents. This allowed us to reconstruct the original design and make evident how European ideas were adjusted to the particularities of the American territory, thus contributing to the improvement of knowledge about Spanish military architecture in America.
Glazed Pottery Throughout the Middle and Modern Ages in Northern Spain
Authors: Alonso-Olazabal Ainhoa , Quirós Castillo Juan Antonio , Zuluaga Maria Cruz , Ortega Luis Ángel
Published: January 2025

A total of forty samples of medieval and modern glazed pottery from northern Spain were studied. Chemical and microstructural analyses of the glazes were performed by scanning electron microscopy coupled with electron dispersive spectroscopy (SEM-EDX), while the chemical composition of the pottery bodies and slips were determined by X-ray Fluorescence (XRF). The glazes studied come from the Santa Barbara Hill site (Tudela), the Treviño Castle site (Treviño), the Vega workshop (Burgos) and the Torrentejo village (Labastida) and correspond to transparent glazes and opaque white glazes. Transparent glazes were lead glazes with variable PbO content. Opaque white glazes were lead-tin and lead–alkaline–tin glazes. The glaze was mainly applied to a pre-fired body made of local clays, but the glazes of the Santa Barbara Hills pottery (Tudela) were applied to raw bodies. The microstructure of the interfaces indicates a single firing process for the glazed pottery from Tudela and a double firing process in the rest of the sites. Some correlation are identified between the use of specific clays to produce different glaze colours. White opaque glazes are applied to calcium-rich clays. Similarly, calcium-rich clays were used to produce dark green transparent glazes, while clays and slips aluminium–rich were used to produce light green and light honey glazes. Iron was also identified as the main colouring agent, although copper was also used. The white glazes were opacified by the addition of cassiterite and sometimes quartz and feldspar. The glazed pottery was mainly of local origin, but the identification of some non-local pottery at all sites suggests a pottery trade.
Workplace Health and Wellbeing in Small and Medium Sized Enterprises (SMEs): A Mixed Methods Evaluation of Provision and Support Uptake
Authors: Lloyd Nigel , Smeeton Nigel , Freethy Imogen , Jones Julia , Wills Wendy , Dennington-Price Abi , Jackson John , Brown Katherine
Published: January 2025

Today’s challenging times highlight the need for workplaces to support employee wellbeing. Workplaces can offer a means to improve employee wellbeing and promote health initiatives. However, small and medium-sized enterprises (SMEs) are less likely than larger organizations to engage with workplace wellbeing initiatives or offer wellbeing provision. This study, conducted in an urban area in central England, explores SME engagement with local government workplace wellbeing provision, and barriers and facilitators to SME engagement, SME implementation of wellbeing provision, and employee uptake. A mixed-methods design was used. Quantitative data were collected via a survey of 103 SMEs and qualitative data from three focus groups with stakeholders involved in promoting SME engagement with wellbeing support (n = 9) and 16 in-depth interviews with SME representatives (n = 8) and employees (n = 8). Quantitative data were analyzed using the chi-squared, Fisher’s exact and Mann-Whitney U tests, and multivariable logistic regression. Qualitative data were analyzed using framework analysis. Findings highlighted several interrelated factors acting as barriers and facilitators to SME engagement with wellbeing initiatives, SME-provided wellbeing provision, and employee uptake. The study provides valuable insights for policymakers, public health teams, and SME leaders on improving provision of and engagement with wellbeing programs. Trust, awareness, knowledge, and communication are highlighted as important prerequisites of optimal provision and engagement.
Insights into the Corrosion Inhibition Performance of Plant Extracts of Different Genera in the Asteraceae Family for Q235 Steel in H2SO4 Medium
Authors: Chu Tian-Shu , Mai Wen-Jie , Li Hui-Zhen , Wei Bo-Xin , Xu Yu-Qing , Liao Bo-Kai
Published: January 2025

Nowadays, the development of plant extracts as corrosion inhibitors to protect metals from corrosion is a popular research direction. However, given the vast diversity of plant species in nature, it is imperative to explore effective methods to improve screening efficiency in order to quickly identify the corrosion inhibition potential of plants. In this work, a new strategy for developing plant-extracted eco-friendly corrosion inhibitors based on the family and genus of plants is proposed. Three plants of different genera in the Asteraceae family, including Artemisia argyi extract (AAE), Chrysanthemum indicum extract (CIE), and Centipeda minima extract (CME), were selected and successfully prepared as novel corrosion inhibitors for Q235 steel in a sulfuric acid solution. The corrosion inhibition behavior and corresponding mechanism were systematically investigated by using some electrochemical tests (open circuit potential, potentiodynamic polarization, and electrochemical impedance spectroscopy) and surface characterizations (Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy). The experimental results illustrated that the main components of the three extracts were similar and that when combined with KI as mixed-type corrosion inhibitors, they could dramatically slow down the metal corrosion rate. The maximum value of the corrosion inhibition efficiency reached 96.29%, 96.50%, and 97.52%, respectively, at 200 mg/L and could increase to 98.64%, 97.65%, and 99.06%, respectively, with a prolonged immersion time. A synergistic effect exists between the three plant extracts and KI, leading to the firm adsorption of the three plant extract molecules onto a Q235 steel surface, thereby forming a robust protective film. This work demonstrated that plants of different genera in the Asteraceae family possessed similar corrosion inhibition capabilities, providing a novel way to select potential corrosion inhibitors from numerous plants based on family and genus classification.
Combined Transcriptomics and Metabolomics Uncover the Potential Mechanism of Plant Growth-Promoting Rhizobacteria on the Regrowth of Leymus chinensis After Mowing
Authors: Yuan Ting , Ren Weibo , Zhang Jiatao , Mahmood Mohsin , Fry Ellen L. , Meng Ru
Published: January 2025

Mowing significantly influences nutrient cycling and stimulates metabolic adjustments in plants to promote regrowth. Plant growth-promoting rhizobacteria (PGPR) are crucial for enhancing plant growth, nutrient absorption, and stress resilience; however, whether inoculation with PGPR after mowing can enhance plant regrowth capacity further, as well as its specific regulatory mechanisms, remains unexplored. In this study, PGPR Pantoea eucalyptus (B13) was inoculated into mowed Leymus chinensis to evaluate its effects on phenotypic traits, root nutrient contents, and hormone levels during the regrowth process and to further explore its role in the regrowth of L. chinensis after mowing. The results showed that after mowing, root nutrient and sugar contents decreased significantly, while the signal pathways related to stress hormones were activated. This indicates that after mowing, root resources tend to sacrifice a part of growth and prioritize defense. After mowing, B13 inoculation regulated the plant’s internal hormone balance by reducing the levels and signal of JA, SA, and ABA and upregulated the signal transduction of growth hormones in the root, thus optimizing growth and defense in a mowing environment. Transcriptomic and metabolomic analyses indicated that B13 promoted nutrient uptake and transport in L. chinensis root, maintained hormone homeostasis, enhanced metabolic pathways related to carbohydrates, energy, and amino acid metabolism to cope with mowing stress, and promoted root growth and regeneration of shoot. This study reveals the regenerative strategy regulated by B13 in perennial forage grasses, helping optimize resource utilization, increase yield, and enhance grassland stability and resilience.
Risk Factors for Coronary Events After Robotic Hybrid Off-Pump Coronary Revascularization
Authors: Dokollari Aleksander , Bacchi Beatrice , Sicouri Serge , Cabrucci Francesco , Bonacchi Massimo , Spragan Danielle , Wertan Mary Ann C. , Ghorpade Nitin , Kjelstrom Stephanie , Montone Georgia , Yamashita Yoshiyuki , Ramlawi Basel , Sutter Francis
Published: January 2025

Objectives: The impact of long-term complications after robotic hybrid coronary revascularization (HCR), including persistent angina, repeat revascularization, and myocardial infarction (MI), remains limited. This study aims to determine the risk factors for coronary events after robotic HCR and their time-varying effects on outcomes. Methods: We identified all consecutive patients who underwent robotic HCR at our institution. Baseline characteristics were explored as possible risk factors for angina, MI, and repeat revascularization with stents at any time during the follow-up. Results: A total of 875 patients (mean age 71.1 ± 11.1 years) were included. After a median follow-up of 3.32 years (IQR 1.18–6.34 years), angina occurred in 134 patients (15.3%), repeat revascularization with stents in 139 patients (15.8%), and MI in 36 patients (4.1%). The hazard rates for all outcomes increased with follow-up time, with a notable early rise around two years of follow-up for angina and, to a lesser extent, repeat revascularization. The risk factors were the lack of radial artery graft use, black race, diabetes, obesity, chronic obstructive pulmonary disease, low ejection fraction <50%, severe left main coronary artery stenosis (>50%), and more than three-vessel disease. Conclusions: Optimization of modifiable periprocedural risk factors may positively impact long-term prognosis in patients undergoing robotic HCR.
Senear–Usher Syndrome or Coexistence of SLE with Pemphigus Vulgaris—A Case Report with Literature Review
Authors: Kutwin Magdalena , Kądziela Marcelina , Stein Tomasz , Kraska-Gacka Marzena , Woźniacka Anna , Żebrowska Agnieszka
Published: January 2025

Senear–Usher syndrome, or pemphigus erythematosus (PE), is a rare autoimmune disorder characterized by the coexistence of features from both lupus erythematosus (LE) and pemphigus foliaceus (PF). We describe a 41-year-old patient initially diagnosed with cutaneous and then systemic lupus erythematosus (SLE), who after a few years developed new skin lesions: erythematous and erosive eruptions partially covered by crusts located on the trunk and flaccid blisters on the extremities. Direct immunofluorescence of perilesional skin revealed deposits of IgG in the intercellular space of the epidermis and granular deposits of C3 at the dermo–epidermal junction. Additional testing, revealing autoantibodies against the intercellular space of the epidermis, and direct immunofluorescence (DIF) examination allowed a diagnosis of pemphigus vulgaris coexisting with lupus. Further, DIF study revealed granular deposits of immunoglobulin G (IgG) in the intercellular spaces of the epidermis and granular deposits of the C3 along the basement membrane. Clinical appearance led to suspicion of Senear–Usher syndrome. in this patient. This case report explores the diagnostic challenges posed by the patient’s overlapping symptoms and immunological findings, suggesting an infrequent manifestation of Senear–Usher syndrome or a combination of SLE and pemphigus vulgaris. The case highlights the complexity of chronic inflammatory skin diseases and the need for tailored treatment approaches in such cases. Despite temporary improvement, the patient experienced relapses. We performed a descriptive literature review of the case reports of PE published in the last 24 years and prepared a summary of the characteristics, emphasizing the importance of proper recognition, clinical features, and treatment of this uncommon syndrome.
Classifying Low Back Pain Through Pain Mechanisms: A Scoping Review for Physiotherapy Practice
Authors: Tedeschi Roberto , Giorgi Federica , Platano Daniela , Berti Lisa
Published: January 2025

Background: Low back pain (LBP) is a leading cause of disability worldwide, often driven by distinct pain mechanisms: nociceptive, neuropathic, and central sensitization. Accurate classification of these mechanisms is critical for guiding effective, targeted treatments. Methods: A scoping review was conducted following the Joanna Briggs Institute methodology and reported according to PRISMA-ScR guidelines. A comprehensive literature search was performed in MEDLINE, Cochrane CENTRAL, Scopus, PEDro, and Web of Science. Eligible studies included adults with LBP and focused on clinical criteria for classifying pain mechanisms. Data on study methods, population characteristics, and outcomes were extracted and synthesized. Results: Nine studies met the inclusion criteria. Nociceptive pain was characterized by localized symptoms proportional to mechanical triggers, with no neurological signs. Neuropathic pain was associated with burning sensations, dysaesthesia, and a positive neurodynamic straight leg raise (SLR) test. Central sensitization featured widespread pain, hyperalgesia, and disproportionate symptoms. Tools such as painDETECT, DN4, and the Central Sensitisation Inventory (CSI) were validated for neuropathic and central sensitization pain. Central sensitization and neuropathic pain were linked to greater disability and psychological distress compared to nociceptive pain. Conclusions: This review aims to provide a historical perspective on pain mechanism classifications and to explore how previous frameworks have influenced current diagnostic concepts in physiotherapy practice. By synthesizing key clinical criteria used to differentiate between nociceptive, neuropathic, and central sensitization pain, this review proposes a practical framework to improve the accuracy of pain classification in clinical settings.