bluuebunny/crossref_metadata_2025 huggingface dataset:
Ernesto Benedicto Ottoni e a construção da carreira médica: entre leituras, práticas e produção do conhecimento (1841-1881)
Authors: Abreu Jean Luiz Neves
Published: August 2023

RESUMO O artigo busca reconstituir a trajetória do médico Ernesto Benedicto Ottoni, entre 1841 e 1881. Personagem pouco reconhecido pela historiografia, sua biografia, contudo, traz elementos relevantes para uma reflexão sobre a carreira médica no século XIX. A proposta se insere na perspetiva de outros estudos que, a partir de casos particulares, contemplam as diversas formas de inserção dos médicos na sociedade imperial. Pretende-se mostrar os recursos que esse médico mobilizou para construir seus espaços de atuação, os quais envolviam tanto o reconhecimento acadêmico, como o exercício de funções junto ao Estado e relações familiares e sociais, aspectos inerentes ao exercício da profissão médica do período.
Erich Auerbach e a apologia das ações modestas
Authors: Reis Patrícia
Published: August 2023

RESUMO Este artigo analisa os primeiros estudos de Erich Auerbach sobre Dante Alighieri, produzidos na década de 1920, de modo a salientar as rivalidades teóricas e políticas que atravessavam o ambiente acadêmico em que ele estava inserido. Dentre as tendências interpretativas que se estabeleceram após a Primeira Guerra Mundial sublinha-se a busca pela relevância atual da Divina comédia para a sociedade alemã. Por um lado, essa inclinação fundamentou leituras ufanistas e racialistas de Dante, e por outro, embasou a defesa da unidade da cultura europeia que, em alguma medida, seu poema permitiria vislumbrar. Os textos de Auerbach situam-se no segundo grupo, posto que, nos versos dantescos, para além da orientação teórica de sua reflexão sobre a literatura, ele teria encontrado o sentido do seu envolvimento no mundo enquanto filólogo europeu.
A revista S. Paulo (1936): fotomontagem e propaganda política na década de 1930
Authors: Coelho George Leonardo Seabra
Published: August 2023

RESUMO Este artigo apresentará o ideário do Movimento Bandeira e a composição imagética da revista S. Paulo (1936). Nosso objetivo será discutir como o ideário desse movimento político-cultural foi utilizado como estratégia discursiva para compor a visualidade do referido órgão publicitário. Para apresentarmos essa apropriação, faremos a exposição das formas como a produção cafeeira, a cidade de São Paulo e o “mito bandeirante” foram trabalhados visualmente nesse periódico. Consideramos que a leitura da revista S.Paulo será de extrema relevância, uma vez que apresentaremos a interação entre o ideário do Movimento Bandeira e os usos políticos das fotomontagens. Com a análise, esclareceremos os meios pelos quais o corpo editorial da revista lançou mão da fotografia e da fotomontagem para transmitir uma mensagem política.
Más allá del “silencio” y del “mito del silencio”: Hannah Arendt, lo dicho y lo decible sobre el Holocausto en la posguerra (1945-1963)
Authors: Bevilacqua Gilda
Published: August 2023

RESUMEN En este trabajo abordaremos la cuestión de lo dicho y lo decible sobre el Holocausto en el marco del “discurso social” hegemónico de posguerra, analizando, primero, dos posturas contrapuestas: la del “silencio” y la del “mito del silencio”. Luego, presentaremos la categoría “alertadores de incendio” de Enzo Traverso, para matizarlas y destacar cómo el campo de lo decible estaba condicionado tanto por la coyuntura socio-política como por las formas discursivas dominantes; y, finalmente, desarrollaremos el caso de Hannah Arendt, inscripto en dicha categoría, atendiendo los cambios en su producción sobre los crímenes nazis (1945-1963), en el contexto de su marco investigativo en Estados Unidos, para mostrar cómo lo decible se cristaliza, hasta que irrumpen nuevos discursos, nuevas disputas.
Notes on Jerzy Grotowski and Maud Robart’s Researches on Afro-diasporic Chants
Authors: Matricardi Luciano
Published: August 2023

ABSTRACT This paper discusses the transcultural investigations conducted by Jerzy Grotowski on traditional AfroDiasporic chants. Based on some notes on the collaboration with the Haitian artist Maud Robart, it argues that these investigations were not aimed at the expropriation of traditional performative knowledge, the emptying of its meanings or the aestheticization of its forms. In its political dimension, as it seeks to delineate, it was a work that had the potential to relativize the usual modes of perception of the individual, especially the modern and western one, towards what could be called a ‘decolonization of the self’.
A CONCEPÇÃO CÍVICO-MILITAR DE EDUCAÇÃO INTEGRAL E(M) TEMPO INTEGRAL
Authors: Silva Bruno Adriano Rodrigues da
Published: August 2023

RESUMO O artigo sustenta que está em curso na política educacional brasileira uma concepção cívico-militar de educação integral e(m) tempo integral proveniente do governo de Jair Messias Bolsonaro (2019–2022) que estabeleceu diretrizes para o desenvolvimento do Programa Nacional das Escolas Cívico-Militares. Recorremos ao historicismo como método, para situar a educação integral e(m) tempo integral, e à revisão bibliográfica e análise documental, para em primeiro lugar ter um entendimento geral sobre o objeto, o referido programa, e em segundo identificar informações factuais (norteadas pelo que aqui argumentamos) em legislações e reportagens veiculadas na grande rede que evidenciaram a concepção cívico-militar de educação integral e(m) tempo integral em curso, percebendo também, a título de um exemplo prático, os primeiros movimentos de uma escola do município do Rio de Janeiro (RJ).
Magnesium thermophosphates from the Maicuru complex as sources of P and Mg in maize production
Authors: Castro Cesar de , Costa Marcondes Lima da , Firmano Ruan Francisco , Guardani Roberto , Silva George Rodrigues da
Published: August 2023

Abstract The objective of this work was to investigate changes in soil chemical characteristics, phosphorous concentrations in maize leaves, and the agronomic efficiency (AE) of magnesium thermophosphates produced from rocks of the Maicuru complex in the Brazilian Amazon Basin, in comparison with triple superphosphate (TSP). The thermophosphates consisted of a mixture of raw material from apatite, dunite, and quartz sandstone from Maicuru, aiming to adjust the contents of P, Mg, and Si. The mixture was melted, ground, and subjected to the analysis of solubility, chemical characteristics, and granulometry. The experiment consisted of two rates of dolomitic lime (0 and 2.4 Mg ha-1), three rates of P (20, 60, and 100 mg kg-1 soil), and four sources of P (TSP and three Mg thermophosphates), as well as of two control treatments, with and without lime. Three replicates were carried out per treatment in pots containing plants of the BR 5107 maize hybrid. Phosphorous concentration was determined in maize leaves at 45 days after sowing. The Mg thermophosphates showed a high AE and a higher neutralizing effect with the application of lime, which improved soil chemical characteristics and AE. The thermophosphates obtained from rocks of the Maicuru complex can be an alternative P fertilizer in maize production.
Análisis de la competencia digital de futuros profesionales de la educación en tiempos de pandemia
Authors: Magaña Ernesto Colomo , Méndez Vicente Gabarda , Ariza Andrea Cívico , Monzonís Nuria Cuevas
Published: August 2023

Resumo La pandemia ha conllevado cambios sustanciales en diferentes ámbitos, incluido el educativo. En este supuso, entre otras cosas, el cambio de una modalidad presencial a una modalidad en línea o híbrida en la educación superior, convirtiendo a la tecnología en el medio necesario para continuar con el proceso formativo. La competencia digital del alumnado se convertía, de manera directa, en una pieza clave del propio proceso, una cuestión especialmente relevante en el caso de los futuros docentes, llamados a desarrollar no solamente sus propias destrezas, sino también las del alumnado. Bajo esta perspectiva, este artículo trata de analizar la evolución de la competencia digital del alumnado del Grado en Educación Primaria y Pedagogía de la Universidad de Málaga a raíz del cambio de modalidad motivado por la pandemia. Se atiende, de manera específica, al sexo y la titulación como posibles variables condicionantes del nivel de habilidades tecnológicas. Se utiliza para ello un cuestionario validado orientado de manera explícita a evaluar el nivel de competencia digital de futuros docentes con un enfoque cuasiexperimental de pretest-postest. Los resultados muestran que sí hay una evolución en las destrezas tecnológicas del alumnado, siendo los hombres y, específicamente aquellos estudiantes que habían cursado previamente alguna asignatura con contenidos de tecnología de la Información y la Comunicación (TIC), quienes muestran un mayor nivel de competencia digital.
Arboviruses: Transmission and Host Resistance
Authors: Anwar Sidra , Ahmed Bilal , Qadir Muhammad Imran
Published: August 2023

In this review, there is a complete description of the classes of arboviruses, their evolutionary process, virus characterization, disease transmission methods; it also describes about the vectors involved in transmission and their mood of transmission, both biologically as well as non-biologically and, about host, the resistance mechanism in host, and artificial methods of preventing those viral transmissions. Arboviruses transmitted to hosts by some vectors such as mosquitoes, ticks, etc. The virus replicates in the host can be prevented by some host resistance mechanisms like RNA interference (RNAi), which degrade virus RNA by its antiviral activity, insect repellents, IGRs, and PI technology.
A Scoping Review to Assess Risk of Fracture Associated with Anxiolytic Medications
Authors: Dallman Johnathan , Aldag Levi , Klass Amanda , Hadley Morgan , Clary Steven , Tarakemeh Armin , Zackula Rosey , Morey Tucker , Vopat Bryan
Published: August 2023

Introduction. Recent research has focused on evaluating the impact of pharmalogical sources on fracture risk. The purpose of this study was to review the literature on anxiolytic medications that may be associated with an increased risk of fracture.

Methods. A search was conducted in MEDLINE and Embase databases to identify primary clinical studies of patients who sustained a fracture while prescribed anxiolytic medications and were published prior to July 2021. Anxiolytics defined by ATC Class N05B, beta blockers, and zolpidem were included. The search terms consisted of variations of the following: (“Psychotropic Drugs” or MeSH terms) AND (“Fracture” or MeSH terms). 

Results. Of 3,213 studies, 13 (0.4%) met inclusion criteria and were evaluated. Fractures associated with benzodiazepine were reported in 12 of 13 studies; the highest risk occurred in patients aged 60 years and older, RR=2.29, 95% CI (1.48-4.40). The ATC Class N05B showed an increased fracture risk for those < 55 years of age that differed by sex: for men RR=5.42, 95% CI(4.86-6.05) and for women it was RR=3.33, 95% CI (3.03-3.66). Zolpidem also showed an increase fracture risk, RR=2.29, 95% CI(1.48-3.56), but only during the first 4 weeks of treatment. A relative risk of 0.77, 95% CI(.72-.83) was observed for beta blockers.

Conclusions.  Fractures are a mainstay of traumatic injuries and are accompanied by economical, physiological, and psychological hardship. Fortunately, with proper assessment and prophylactic measures, fracture risk can be reduced dramatically. Anxiolytic medications have been described widely to increase fracture risk, such as benzodiazepines  in 60+ year old patients, and ATC Class N05B Anxiolytics increased fracture risk of RR=5.42, 95% CI (4.86-6.05) in 55+ year old men and  in 55+ year old women. Yet, some studies showed that at low doses, nitrazepam lowered fracture risk. Other anxiolytic medications, such as zolpidem and beta blockers, also showed a decrease in fracture risk; however, only one study has been published on each of these medications. Ultimately, this scoping review helped to illuminate the inconsistency of anxiolytic fracture risk assessment while simultaneously illustrating the necessary steps to guide future research.
Redes sociales y crisis humanitarias
Authors: Torres-Toukoumidis Ángel , De-Santis Andrea
Published: August 2023

Doblegarnos a pensar que no existen o jactarse en polarizaciones insulsas es el discurso más reducido e insensato. Las crisis humanitarias están presentes y son incómodas. Por ello, esta vez, en un ejercicio de sistematización pero también de reflexión, los jóvenes de 2do ciclo de la carrera de Comunicación de la Universidad Politécnica Salesiana-sede Cuenca, se atrevieron a romper paradigmas y a profesionalizar su escritura dentro del campo de la investigación participando en la segunda entrega de esta colección. En la primera participaron estudiantes de 8vo ciclo y se concentraron en los medios digitales, analizando los casos de Haití, Honduras, Venezuela, Rusia-Ucrania, y Siria (Torres Toukoumidis et al., 2022). No obstante, esta vez, un curso que apenas comenzaba a conocer el amplio mundo de la investigación, asumieron la responsabilidad de profundizar sobre las redes sociales y su relación con las crisis humanitarias.
Determination of Amino acid Profile and Some Characteristics of Collagen Extracted from Skin and Bone of Luciobarbus esocinus (Heckel, 1843)
Authors: GÖÇER Mustafa , YANAR Yasemen , AYDIN Muhsin
Published: August 2023

Acid soluble collagens (ASC) from bone (ASC-B) and skin (ASC-S) of mangar (Luciobarbus esocinus (Heckel, 1843) were extracted, characterized, and their amino acid profiles were determined. To best of our knowledge, the current study is the first research that used this species as a source of collagen. Both ASC-S and ASC-B from mangar skin and bone contained glycine as the major amino acid and high amounts of proline, hydroxyproline, alanine, and glutamic acid. On the basis of dry weight, yields of ASC-S and ASC-B were 9.38 and 3.71%, respectively. Furthermore, fourier transform infrared spectroscopy proved that both collagens were integrated and native. Additionally, the results of XRD demonstrated that both of the collagens reserved their helical structures. The screened collagens had prominent absorptions at 230 nm by UV-Vis spectra. Additionally, the SEM studies have shown that both ACS-S and ASC-B have porous and fibrous nature. According to the UV–Vis and FTIR results, extracted collagens were characterized as type I collagen based on their amino acid composition. According to the obtained results, the collagen isolated from mangar can potentially be an alternative source of vertebrate collagens for use in the diet and other industries such as medical and pharmaceutical industries.
AKCİĞER KONTÜZYON HACMİ: GERÇEKTEN BİLİYOR MUSUNUZ?
Authors: TULAY Cumhur Murat , SAĞLAM GÜRMEN Ekim
Published: August 2023

Amaç

Pulmoner kontüzyon, künt göğüs travmasının en yaygın

komplikasyonlarından biridir. Bir hekimin pulmoner

kontüzyonun boyutunu ve gerçek miktarını belirlemesi

bazen çok zordur. Çalışmanın amacı bilgisayarlı

tomografi görüntüleri üzerinde Cavalieri prensibi ile

manuel planimetri yöntemini kullanarak doğru pulmoner

kontüzyon hacmini ölçmektir.

Gereç ve Yöntem

Çalışma “Acil Tıp Kliniğine”, akciğer kontüzyonu ile

başvuran 76 hasta üzerinde yapıldı. Hasta verileri retrospektif

olarak tarandı ve akciğer kontüzyonu olan

hastaların bilgisayarlı tomografi görüntüleri akciğer

kontüzyon hacmini hesaplamak için incelendi. Tüm

akciğer kesitlerinde ölçüm yapıldıktan sonra, sistemik

randomize örnekleme ile 6-8-10 kesitte akciğer

kontüzyon hacmi hesaplandı. Kontüzyon hacmi iki

bağımsız gözlemci tarafından manuel planimetri yöntemi

kullanılarak hesaplandı.

Bulgular

Tüm kesit ölçümlerinden elde edilen ortalama kontüzyon

hacmi %34.23 ± 17.56 idi. Kontüzyon hacmi 6 kesit

ölçümünde %27,98±15,05, 8 kesitte %30,66±16,07

ve 10 kesitte %32,47±16,97 idi. Bland Altman grafiklerini

incelediğimizde 10 kesitten elde edilen ortalama

farkın 6 ve 8 kesit ölçümlerine göre daha küçük olduğu

ve güven aralığının daha dar olduğu görülmektedir.

Dolayısıyla 10 kesit ölçümünün yaklaşık %95 doğruluk

oranı ile tüm akciğer kontüzyon ölçümlerine en

yakın değerlendirmeyi verdiğini söyleyebiliriz.

Sonuç

Akciğer kontüzyon hacmi, BT'de tüm akciğer alanı

ölçümü olmaksızın sistematik rastgele örnekleme ile

manuel planimetri yöntemi kullanılarak yüksek gözlemciler

arası ve gözlemci içi uyum ile objektif olarak

değerlendirilebilir.
MAGNETIC RESONANCE CHOLANGIO PANCREATICOGRAPHY (MRCP) DETECTION OF WHETHER THE JUNCTION OF THE CYSTIC DUCT TO THE COMMON BILE DUCT IS ASSOCIATED WITH THE DEVELOPMENT OF GALLSTONES AND/OR CHOLECYSTITIS
Authors: KARAKAŞ Levent , ULUKENT Suat Can , KAYA Mehmet Fatih , YILDIZ Eren Ozan , YÜNLÜEL Emir Mehmet , GÜRKAN Okan
Published: August 2023

Objective

The development of gallstones and stone-induced

inflammatory processes depends on a number of

biological factors. Knowledge of the predisposing

factors for both the development of stones and their

inflammation is important in predicting, monitoring,

and treating the disease and managing subsequent

complications. The aim of our study was to determine

whether the length of the cystic duct (CD), the level

and direction of the junction of the cystic duct with

the common hepatic duct (CHD) are associated with

cholecystitis and cholelithiasis.

Material and Method

This retrospective study included 172 patients

who underwent MRCP between January 2017 and

December 2020. A 1.5 Tesla MR device (Signa HDI,

General Electric, Milwaukee, WI, USA) was used with

an HD 8-channel body array coil. The findings were

analyzed using SPSS version 23 software.

Results

The level at which the CD merged with the main CHD

was not significantly correlated with the development

of calculi and/or cholecystitis (p>0.05). Similarly, there

was no significant correlation between the direction of

the CD opening into the CHD and the development

of calculi and/or cholecystitis (p>0.05).Of 27 (15.7%)

cases with CD length less than 2 cm, 3(11.1%) had

only stones, 8 (29.6%) had cholecystitis and 16

(59.2%) were normal. Of 88 (51.2%) cases between

2 and 4 cm, 43 (48.8%) had only calculi, 19 (21.5%)

had cholecystitis with calculi and 26 (29.5%) were

normal. Of 57 (33.1%) patients with cystic duct longer

than 4 cm, 31 (54.3%) had only stones, 16 (28%)

had cholecystitis and 10 (17.5%) were normal. As

CD length increased, the frequency of stone and/or

cholecystitis increased (p
Are Emotions Valueceptions or Responses to Values? Husserl’s Phenomenology of Affectivity Reconsidered
Authors: Delamare Alexis
Published: August 2023

How are we able to experience values? Two sides are competing in contemporary literature: ‘Meinongians’ (represented notably by Christine Tappolet) claim that axiological properties are apprehended in emotions, while ‘Hildebrandians’ (represented in particular by Ingrid Vendrell Ferran) assert that such experiences of value (or valueceptions) are accomplished in special ‘value feelings’, and that emotions are only responses to these felt values. In this paper, I study the Husserlian viewpoint on this issue. I reveal that, contrary to what almost all scholars have assumed so far, Husserl’s position is not reducible to Meinong’s and must on the contrary be regarded as an innovative and stimulating approach that helps unifying the two standard frameworks. It indeed recognizes (with Hildebrandians) the existence of non-emotional value feelings, while maintaining (with Meinongians) that originary axiological experiences are necessarily emotional.
Electron microscopy (EM) analysis of LRRK2-Nanotube assembles v1
Authors: Wang Xinbo
Published: August 2023

This protocol details methods for the analysis of LRRK2-Nanotube assembles by negative stained EM and Cryo-EM.
In vitro GTPase activity v1
Authors: Wang Xinbo
Published: August 2023

This protocol details methods for the in vitro GTPase activity testing of purified LRRK2.
DIMPLE library generation and assembly protocol v1.1 v2
Authors: Macdonald Christian
Published: August 2023

This is a protocol for generating and QCing mutagenic libraries using the DIMPLE protocol. This version is updated to include expanded descriptions of QC and to clarify certain steps.
The (Re)Industrialised Waterfront as a “Fluid Territory”: The Case of Lisbon and the Tagus Estuary
Authors: Costa João Pedro , Andrade Maria J. , Dal Cin Francesca
Published: August 2023

If delta and estuary areas are observed under the perspective of a double system of dynamic infrastructures, the object of parallel “water/urbanisation” processes, the interface spaces become key nodes. In this perspective, port and waterfront areas can be described as spaces of mediation. The article argues that in the case of Lisbon and the Tagus, as possibly in several other port cities, these edge spaces can be described as “fluid territories.” The pre-eminent characteristic of “fluid territories” is that they are not permanent, neither in space nor time. These areas present accelerated transformations, less defined boundaries, and an increased spatial and management complexity. Moreover, “fluid territories” also mediate (a) the culture-natural environment, with human action appropriating the natural system through infrastructure and urbanisation, and (b) the industrialised economic estuary, with its continuous updating. To demonstrate this hypothesis, two samples of Lisbon’s riverfront are observed, recording its constant variability over the last 200 years of industrialisation, emphasising the “fluidity” of the mediating spaces. The understanding of the “fluid” characteristic of water/land mediation spaces is relevant for the present. Being dynamic and regularly reinventing spaces, spatial planning, public space, and architectural design processes in “fluid territories” should increasingly seek adaptability, flexibility, and openness to change. In the climatic context of continuous uncertainty combined with the need to make room for infrastructure, rethinking mediation areas through the lens of the theoretical concept of the “fluid territory” enables the implementation of urban transformation processes consistent with contemporary challenges.
Antimicrobial activity of the complement system
Authors: Egorova Ekaterina V. , Krenev Ilia A. , Oborin Nikita N. , Berlov Mikhail N.
Published: August 2023

The complement system plays a key role in homeostasis and defense against pathogens. The antimicrobial activity of serum against Gram-negative bacteria is usually attributed to the action of the membrane attack complex. However, there is increasing evidence that some other components of the complement system and the products of its activation are also capable of direct killing of both Gram-negative and Gram-positive bacteria. In the course of complement activation, anaphylatoxins C3a, C4a, C5a are produced, which, in addition to their main function, can exhibit a bactericidal effect and disrupt the bacterial membrane. Recent studies have shown that in fish, complement factors D, I, as well as a Ba fragment of factor B, are able to neutralize pathogens. The triggering and amplification of complement usually occurs on the surface of pathogen cells, so the local production of antimicrobial components can potentially make a significant contribution to their elimination. The aim of this review is to outline the role of individual complement members in the elimination of pathogens through direct antibiotic action. The problem of antimicrobial protection in the context of therapeutic complement inhibition is considered.
Immunohistochemical study of human pineal vessels
Authors: Sufieva Dina A. , Fedorova Elena A. , Yakovlev Vladislav S. , Grigorev Igor P.
Published: August 2023

BACKGROUND: The pineal gland is a neuroendocrine organ located in the epithalamic area of the brain. By using the melatonin, a pineal hormone, the pineal gland synchronizes the work of the internal physiological systems of the body with the circadian light-darkness cycle. Melatonin is synthesized in pinealocytes, the endocrine cells of the pineal gland, and secreted into the bloodstream. However, the structural features of the blood vessels in the pineal gland are still not well understood.
AIM: The purpose of this study was to elucidate the intraorgan localization and immunohistochemical pattern of the blood vessels of the pineal gland of human, which had not been previously studied.
MATERIALS AND METHODS: In the research, immunohistochemistry methods were applied using two selective markers of blood vessels, the antibodies to von Willebrand factor and type IV collagen. Von Willebrand factor is expressed selectively in endothelial cells that form blood vessels, including small capillaries, while type IV collagen is inherent to the basement membrane that separates the vascular endothelium from the underlying tissue.
RESULTS: The immunohistochemical reaction to both markers clearly visualize the blood vessels of the human pineal gland, which in both cases were observed mainly in the connective tissue septa (trabeculae), or, in the absence of a regular lobular structure, in the connective tissue layers. In lobules surrounded by connective tissue trabeculae and containing a large number of densely packed pinealocytes, von Willebrand factor- and type IV collagen-immunoreactive structures were very rare, and in many cases were not observed. The found phenomenon of distribution of blood vessels in the human pineal gland is described for the first time.
CONCLUSIONS: Since blood vessel markers with well-proven selectivity were used, the results obtained with their usage can be considered reliable; this gives grounds with a high degree of probability to assert that the majority of pinealocytes in the human pineal gland do not have direct contact with blood vessels and, accordingly, cannot secrete melatonin directly into the bloodstream. On the basis of the results obtained, a hypothesis is proposed that the hormone secretion from pinealocytes into blood vessels is mediated by astroglial cells.
The molecular mechanisms of drug resistance of glioblastoma. Part 3. Differentiation and apoptosis of glioblastoma cells
Authors: Chernov Alexander N. , Galimova Elvira S. , Shamova Olga V.
Published: August 2023

Glioblastomas are one of the most malignant and frequent human tumors, characterized by rapid growth, metastasis, resistance to therapy and the formation of relapses. The formation of multidrug resistance mechanisms in glioblastomas cells is often combined with inhibition of cell death and differentiation pathways and prevents an increase in the effectiveness of therapy in this group of patients. The review examines the relationship of molecular mechanisms of multidrug resistance with differentiation and apoptosis of glioblastomas with an emphasis on identifying new targets among proteins, microRNAs, suppressor genes, and oncogenes.
Rifampisin Dirençli Mycobacterium tuberculosis Kompleks Suşları Üzerine Benzimidazolyum Tuzlarının Antimikobakteriyel Etkinliğinin Araştırılması
Authors: İNCİ Yaren , KIZILYILDIRIM Suna , KÖKSAL Fatih , MUHAMMED Muhammed Tılahun , AKKOÇ Senem
Published: August 2023

Çalışmada, Sağlık Bakanlığı Adana Bölge Tüberküloz Laboratuvarı’na gönderilen klinik örneklerden izole edilen rifampisin dirençli tüberküloz suşları ile referans suş M. tuberculosis H37Rv üzerine benzimidazol çekirdeği içeren 3 farklı bileşiğin ((S1): 1-(N-metilftalimid)-3-benzilbenzimidazolyum bromür, (S2): 1-(N-metilftalimid)-3-(4-metilbenzil) benzimidazolyum bromür, (S3): 1-(N-metilftalimid)-3-(naftalen-1-ilmetil) benzimidazolyum bromür) antimikobakteriyel aktivitesinin tespiti amaçlandı. Benzimidazol türevi bileşiklerinin rifampisin dirençli 35 klinik M. tuberculosis ve H37Rv suşlarında antimikobakteriyel aktiviteleri in vitro şartlarda BACTEC MGIT 960 sistemi kullanılarak test edildi. Ayrıca, antimikobakteriyel etkili bileşiklerin olası etkileşimleri moleküler doking ile incelendi. Çalışma sonucunda sadece S2 bileşiğinin yalnız M. tuberculosis H37Rv suşuna karşı antimikobakteriyel aktivite gösterdiği, rifampisin dirençli M. tuberculosis suşlarına karşı aktivitesinin olmadığı belirlendi. S1 ve S3 bileşiklerinin ise hem klinik hem de referans suşa karşı antimikobakteriyel aktivitesi tespit edilemedi. Moleküler doking sonuçları S2’nin InhA ile bağlandığını ve onu inhibe ederek antimikobakteriyel etkisini gösterebileceği ortaya çıkardı. Sonuç olarak S2 bileşiğinin tüberküloz tedavisinde yeni ajan olarak sunulabilir ancak daha kapsamlı çalışmaların yapılmasına da ihtiyaç duyulmaktadır.
El derecho de los migrantes rescatados en el mar que soliciten protección internacional a no ser internados
Authors: Girón-Reguera Emilia
Published: August 2023

In recent years, the amount of rescues of migrants arrived to the Mediterranean Sea and the Canarian Islands in watercrafts has increased. With it, controversy has surrounded their internment when they request asylum. This paper studies the regulation of internment by European legislation as interpreted by the European Court of Justice in its pronouncement of June 25, 2020. The analysis shows that the deprivation of liberty constitutes an exceptional and subsidiary measure, since migrants can only be detained if reasons for detention listed in art. 8.3 of the Reception Directive are present, and provided that there are no other alternative measures, less burdensome for the right to personal liberty. In addition, a guarantee model is adopted, which establishes support for the interned applicants and conceives that the right to asylum is undermined with their internment in penitenciary or custody centres whose purpose is to proceed with their return or expulsion. The jurisprudential doctrine included in the analysed judgement reinforces the protection of migrants rescued at sea, enshrining their right not to be interned when they request international protection and, therefore, the obligation of receiving countries to facilitate access to the asylum procedure and, during their processing, give them a dignified accomodation. The commented judgement delves into the growing tendency to approach migration processes from a humanizing perspective.
La recepción de los estándares internacionales frente a la respuesta del estado colombiano en relación con la protección del derecho a la salud de la población migrante
Authors: Pinilla-Rubiano Sarah-Juliana
Published: August 2023

The objective of this article is to analyze the extent to which international standards regarding the protection of the right to health of the migrant population have been received and implemented by the Colombian State in response to the significant influx of Venezuelan migrants resulting from the ongoing crisis. For such purposes, we will review the normative provisions issued by the Colombian government. In addition, we will examine some of the judicial rulings through which the Constitutional Court has guaranteed the right to health to the migrant population. We will also analyze the existing international standards for the protection of the right to health, considering if these have been taken into consideration, both in the legal norms pertaining the increase in the presence of Venezuelan people in Colombian territory and in the Constitutional Court’s rulings. We will analyze these instruments within the timeframe of 2015 to the present, which encompasses the time of the return of many Colombian citizens from Venezuela due to the State crisis that broke out in the neighboring country, which generated an increase in migration. This analysis of standards, judicial decisions (national and international) and regulatory provisions will enable us assess the extent to which the Colombian State has fulfilled its obligation to safeguard the human rights of the migrant population, specifically in terms of the right to health.
Necesidades básicas insatisfechas en los cinco mayores países receptores de migrantes venezolanos
Authors: Lechuga-Cardozo Jorge-Isaac , Sánchez-Gómez Juan-Sebastián
Published: August 2023

The study was aimed at linking theoretically poverty and Venezuelan migration, understanding impoverishment as the dissatisfaction of the basic needs of immigrants in receiving societies. It was framed in an interpretative, non-experimental and transactional methodology, and the data mining technique was used in the 5 main receiving countries of Venezuelan migrants: Brazil, Colombia, Chile, Ecuador and Peru. Besides, the case of the Venezuelan community in Latin America and the Caribbean is presented as a spatial reference. The results showed that unsatisfied basic needs could indeed be an impoverishment factor for the emigrant. Therefore, we concluded that the accommodation, water, health, education and integration sectors, which are related to the dimensions of housing, economic dependency and services, represent half of each of the receiving country’s budget for migrants in 2020. Thus, to prevent Venezuelan migrants and refugees from falling into poverty, it is necessary that there be greater state intervention in the receiving countries, to satisfy these basic needs and thus achieve greater social and labor integration, allowing them better living conditions. in host societies.
Imaginarios sociales sobre población migrante de venezolanos en la escuela. Un análisis desde la bioética social
Authors: Narváez-Lozano José , Gómez-Bustamante Edna
Published: August 2023

This study aims to describe the social imaginaries about the Venezuelan migrant population at school in two public institutions in the city of Cartagena, from the analysis of social bioethics. Through an in-depth interview and a survey, an approach was made to the participants to analyze and describe the social imaginaries about this population. These, according to our findings, still produce discrimination and rejection, especially because of the socioeconomic aspect, despite the different inclusion policies, and the projects in democratic education and values. From these findings, we concluded that it is necessary to continue to reinforce the project in democracy education and values to reduce the rejection actions towards this social group.
La fotoelicitación y el filminuto: técnicas de investigación con niños, niñas y adolescentes migrantes y refugiados
Authors: Feo-Ardila Diana , Espinel-Rubio Gladys , Hernández-Suarez Cesar
Published: August 2023

The instruments and techniques of social and qualitative research for the collection of information, particularly when dealing with children and adolescents in situations of vulnerability, are diverse and particularly aimed at the analysis of drawings, the application of tests and interviews. However, this article identifies the possibilities of using audiovisual production techniques: photo-elicitation and film clips, as instruments for approaching the subjectivities, perceptions, knowledge and attitudes towards the context, identity and culture of children and adolescents who have lived through the experience of forced migration and refuge. With this in mind, we studied the inhabitants of the municipality of Gramalote, displaced by a natural disaster and living in a temporary shelter in Colombia; Afro-descendants internally displaced by the armed conflict in Colombia, resettled in a neighbourhood in Bogotá, and Sahrawi refugees living in the Tindouf camp in Algeria. We stablished that, when noticing the use of cameras, video cameras and mobile phones, the participation of the children and adolescents was decisive, open and spontaneous. During the creative production process within the framework of the photo-elicitation, communication was fluid; as a consequence they managed to provide deep information about their situation, along with manifesting their feelings and making them public without exposure. In addition to expressing the information required for the research, they were able to develop ICT-mediated communicative competences with the film clips, which meant the process had a double result.
Migrantes y nacionales en extraedad: derecho a la educación 2022
Authors: Villa-Guardiola Vera , Rojas-Álvarez María , Fernández-Urueta Lilia , Cianci-Viana Joel
Published: August 2023

Education as a human right enables the realization of other rights and sustainable development. As a fundamental and social right, it generates personal autonomy and progress in the social, economic and democratic spheres. That is the theme of this research, which is linked to the project “Characteristics of the access to the right to education of nationals and migrants in first and second grade of primary school in the Official Educational Institutions of Malambo in 2022”. We took as a starting point the international human rights law and the social reality to propose the objective of describing the conditions provided by the municipality of Malambo to guarantee the right of access to education for over age nationals and migrants in first and second grade in 2022. Out of a mixed research of concurrent execution and descriptive scope, we obtained information through database searches, interviews and questionnaires. The research was conducted in Colombia, a unitary Republic, which outlines the national educational guidelines from the Ministry of Education. The results showed that there is a lack of a national policy that provides a flexible education program for nationals and migrants in first and second grade, which affects the enjoyment of the right to education and its dimensions of availability and accessibility. It is necessary to accompany educational institutions to strengthen the dimensions of adaptability and acceptability. It is concluded that the State infringes the rights of those who deserve special protection by excluding them from the educational system.
La movilidad transfronteriza venezolana en la producción académica: ¿quiénes y qué dice la ciencia?
Authors: Castellanos-Cortes Omaira , Arévalo-Robles Gabriel
Published: August 2023

This article presents the main research findings on scientific production on Venezuelan migration between 2014 and 2021. Using the bibliometric analysis method to observe the global state of science on Venezuelan cross-border mobility, the research measured scientific production with quantitative indicators and analyzed its content with qualitative indicators to identify the main thematic tendencies on what was investigated in a wide set of disciplinary fields. Finally, it discusses the qualitative results showing the gaps and challenges involved in consolidating the lines of research on Venezuelan migration.
Foreign language teachers living and learning in affinity spaces
Authors: Jerez-Rodríguez Sonia , Díaz-Borja Gustavo
Published: August 2023

This qualitative case study delves into the dynamics of three English language teachers living and learning within affinity spaces (AS). To capture comprehensive insights, the research used in-depth interviews and video recorded observations of interactions in AS. The analysis was conducted using Nvivo software for coding and categorizing the collected information. The findings of this study unveil the participants’ active involvement in various AS, with social networks and video games emerging as the most prevalent ones. While individual passions played a role in shaping the content shared, the teachers’ professional interests also significantly influenced the nature of their contributions. Within these affinity spaces, teachers engaged using new literacies, which enabled them to foster social interactions on topics of personal or professional interest, facilitating communication and collaboration, and even assuming different roles. In conclusion, the findings highlight a consistent and enthusiastic engagement of teachers within AS, emphasizing the potential these spaces hold for the evolving nature of education in the learners continue to navigate this landscape, the outcomes offer a valuable roadmap for harnessing the power of AS to foster meaningful learning experiences, authentic communication, and innovative teaching practices among English language teachers.
Analyzing the Influence of Organizational Culture on Co-worker Identity: A Case Study within the Marine Services Sector
Authors: Morelos-Gómez José , Amaris-Puello Lina , Magdaniel-Socarrás Yina
Published: August 2023

This research exhibits the results of the analysis of the corporate culture of a Maritime Services’, company dedicated to the provision of services related to maritime transportation. The use of the deductive method made it possible to reach the objective of describing and obtaining the analysis of its corporate culture through the model of the thirteen dimensions of Zapata, Rodríguez, and Sánchez (2008) using a descriptive and qualitative type of research. Consequently, it was identified that
the company functions as an open system and through a process of internalization and externalization. It has painstakingly forged its unique identity by melding together elements that have evolved since its inception with seamlessly integrated components that have been added progressively over the years.
Untold Stories: Reclaiming Histories of Marginalized Scientists From Archives
Authors: Montana Katherine O. , Kim Rebekah , Quesada-Khoury Karim , Basas Racqyl , Garcia Gabriella , Richardson-Beatty Marion , Voong Viva , Esposito Lauren A.
Published: August 2023

No abstract available.
Promoção a saúde do idoso: experiência de um grupo de cuidados fomentado por residentes multiprofissionais
Authors: Fontenele Allana Rhamayana Bonifácio , Fontenele Kerolayne De Castro , Cunha Kayron Rodrigo Ferreira , Varela Danielle Souza Silva
Published: August 2023

O presente artigo tem como objetivo descrever a experiência de residentes com a criação de um grupo de cuidados e de promoção à saúde para idosas em uma unidade básica de saúde no interior do Piauí. Trata-se de uma pesquisa descritiva, do tipo relato de experiência. Para coleta dos dados foram utilizadas as técnicas de observação participante, produção sistemática de atas sobre os encontros do grupo. Os encontros foram realizados quinzenalmente, conduzidos pela equipe de residentes. A cada encontro foi abordada uma temática de saúde relevante com outras atividades de prevenção de agravos à saúde. Os idosos se tornaram mais resilientes, aprenderam a lidar mais com as adversidades. Consideramos que durante esse percurso conseguimos prevenir um leque de doenças, dentre elas ansiedade e depressão. Também ficou evidente que a educação em saúde em grupo de convivência trouxe resultados efetivos na promoção da qualidade de vida das pessoas que integraram o estudo.
O ESTRANHO E O ORIENTE: HORIZONTES DA HERMENÊUTICA DA COEXISTÊNCIA COTIDIANA DE MARTIN HEIDEGGER
Authors: Marques Rodrigues Bráulio , Pinheiro Braga Arnin Rommel
Published: August 2023

Já em Ser e Tempo (1927), Martin Heidegger enuncia como a tarefa do pensamento que corresponde a um modo de pensar que deve partir do diálogo imediato com outros, promovendo uma abertura cognitiva e hermenêutica que exercita uma nova forma de enxergar no pensamento. O objeto de interpretação neste trabalho é o poema O estranho, de Max Martins, no qual se busca enxergar como se dá essa relação com o outro onde o estranhamento pode ser característico de um encontro com a diferença e com a projeção da constituição ontológica do ente, onde o oriente, ou o orientalismo, pode ser abordado em uma dimensão figurativa, ou seja, na representação de um outro idealizado que surge do esvaziamento discursivo do caráter histórico do Dasein (ser-aí). A fundamentação será baseada em Ser e Tempo da e na leitura heideggeriana da Retórica de Aristóteles como hermenêutica do ser-aí no convívio cotidiano com os outros.
O PRINCIPIO DE FRATERNIDADE EM DESAFIO À MODERNIDADE LÍQUIDA
Authors: Barbosa  Souza Charles Alberto
Published: August 2023

O presente artigo tem como objetivo relatar a necessidade do príncipio da fraternidade na modernidade líquida de Bauman em dialogo com Buber. Nessa linha de pensamento, pensou-se que o direito seria uma descrição precisa e linear dos acontecimentos sociais; entretanto, os fatos da vida na modernidade parecem não seguir essa lógica, pois há nele um dinamismo que transcende esse controle racional. Desta vez, o momento começa a modelar uma disciplina esquecida com base em uma plausibilidade teórica que tende a consolidar premissas irmãs. O percurso teórico desta pesquisa articula- se na lógica do método dedutivo, com tipos de pesquisa qualitativa e técnicas de pesquisa bibliográfica. Em conclusão, este estudo fornece um diagnóstico informado da fraternidade retratada em vários aspectos da modernidade líquida, a fim de promover a ambiguidade do princípio da fraternidade
REFLEXÕES FENOMENOLÓGICAS E HERMENÊUTICAS SOBRE O CONCEITO DE “CORPO PRÓPRIO” DE HUSSERL E O ENVELHECIMENTO NA ATUALIDADE
Authors: Pantoja de Souza Christiane
Published: August 2023

O presente artigo é uma reflexão sobre o envelhecimento hoje, entendendo que neste momento coincidem a maior longevidade da população e um contexto ideológico de busca da “juventude para sempre”. Tal contexto é caracteristicamente midiático, fortemente marcado pelo consumo e contribui decisivamente para a soberania da imagem a partir do imperativo da constante busca pela aparência de juventude, através de grande quantidade e diversidade de produtos a serem consumidos. Para trabalhar o tema, foram utilizados textos de alguns autores que tratam sobre envelhecimento e corporeidade, destacando-se o autor Le Breton e sua percepção da incidência das transformações da técnica sobre o corpo. Dialogamos com os autores a partir do ponto de vista fenomenológico e hermenêutico do conceito Husserliano de “Corpo Próprio”.
Oxidative Stress Mediates the Association between Thyroid Dysfunction and Breast Cancer
Authors: Mahmood Maira , Mushtaq Mazhar , Malik Aamenah , Khurshid Rukhshan , Aamir Faiza , Javed Arham
Published: August 2023

BACKGROUND: Breast Cancer (BC) and thyroid dysfunction are commonly observed ailments in females, and two may occur synchronously. The present study was conducted to find the role of oxidative stress and its association with thyroid dysfunction and BC.METHODS: In this cross-sectional study, 288 and 100 subjects were included in case and control groups, respectively. Serum samples were obtained from consented subjects. Thyroid profile, thyroid antibodies, antioxidant and oxidant profiles, as well as cathepsin S (CTSS), prolactin, and estradiol levels were estimated using specific enzyme-linked immunosorbent assay kits. The data was analyzed using independent Student's t-test and Pearson correlation test.RESULTS: BC cases had higher levels of thyroid antibodies and thyroid stimulating hormone than controls. Prolactin and estradiol levels were also deranged in the case group. Higher oxidative stress biomarkers were evident in the case group; 8-hydroxy-2'-deoxyguanosine (8-OHdG), a DNA damage marker, increased concomitantly. Correlation analysis showed a positive correlation between the antioxidant (catalase) and the oxidant (8-OHdG) levels. Furthermore, the higher level of CTSS in BC cases than in the controls is the hallmark of this study, demonstrating the pathogenesis and progression of the disease.CONCLUSION: Results suggest the mediating role of oxidative stress in the association between thyroid dysfunction and BC. It concludes that the parameters assessed in this study could be indicative of disease progression and metastasis in BC as well as thyroid dysfunction.KEYWORDS: breast cancer, thyroid, oxidant, antioxidant, ROS