bluuebunny/crossref_metadata_2025 huggingface dataset:
TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4 (NLR Family CARD Domain Containing Protein 4) Inflammasome Related Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in Ischemic Stroke
Authors: Deng Yiming , Li Zeyan , Sun Xuan , Ma Ning , Song Ligang , Chen Duanduan , Gao Feng
Published: April 2023

Background:

Neuroinflammation plays extremely crucial roles in the neurological damage mediated by ischemic stroke. TRIM29 (tripartite motif containing 29) has previously been proposed to contribute to the regulation of innate immunity, however, the effect of TRIM29 on ischemic stroke induced neurodegenerative processes and neuroinflammation still largely unexplored. In the current article, we aimed to investigate the function and the precise mechanisms of TRIM29 in ischemic stroke.

Methods:

Middle cerebral artery occlusion mice model and oxygen-glucose deprivation cell model were established as in vivo and in vitro models of ischemic stroke. Quantitative real-time polymerase chain reaction (PCR), Western blot, and ELSIA were used to detect the expression levels of TRIM29, cytokines, and marker proteins. Immunofluorescence assay was performed to examine the extent of cell death. Different truncations were generated, and coimmunoprecipitation assays were used to confirm the protein interaction. Ubiquitination assay was performed to detect the ubiquitination levels.

Results:

We found that the cerebral ischemia-reperfusion induced injury was aggravated in TRIM29 knockout mice after middle cerebral artery occlusion operation as well as the increased neurological deficits score. TRIM29 expression was also found to be up-regulated upon middle cerebral artery occlusion or OGD administration, and loss of TRIM29 promoted the apoptosis and pyroptosis of neurons and microglial cells induced by middle cerebral artery occlusion or OGD, consistent with the enhanced proinflammatory mediators production and activation of NLRC4 (NLR [NOD-like receptor] family CARD [caspase recruitment domain] domain containing protein 4) inflammasome. Furthermore, we observed that TRIM29 interacted with NLRC4 directly and promoted the K48-linked polyubiquitination of NLRC4, lead to the proteasomal degradation of NLRC4.

Conclusions:

In conclusion, for the first time, we revealed the role of TRIM29 in ischemic stroke and illustrated the direct relationship between TRIM29 and NLRC4.
Vascular Risk Predicts Plasma Amyloid β 42/40 Through Cerebral Amyloid Burden in
Apolipoprotein E
ε4 Carriers
Authors: Sapkota Shraddha , Erickson Kelsey , Fletcher Evan , Tomaszewski Farias Sarah E. , Jin Lee-Way , DeCarli Charles ,   for the Alzheimer’s Disease Neuroimaging Initiative*
Published: April 2023

Background:

Understanding the neurobiological underpinnings between established multimodal dementia risk factors and noninvasive blood-based biomarkers may lead to greater precision and earlier identification of older adults at risk of accelerated decline and dementia. We examined whether key vascular and genetic risk impact the association between cerebral amyloid burden and plasma aβ (amyloid β) 42/40 in nondemented older adults.

Methods:

We used nondemented older adults from the UCD-ADRC (University of California, Davis-Alzheimer’s Disease Research Center) study (
n
=96) and Alzheimer’s Disease Neuroimaging Initiative (
n
=104). Alzheimer’s Disease Neuroimaging Initiative was examined as confirmatory study cohort. We followed a cross-sectional design and examined linear regression followed by mediation analyses. Vascular risk score was obtained as the sum of hypertension, diabetes, hyperlipidemia, coronary artery disease, and cerebrovascular disease.
Apolipoprotein E
(
APOE
) ε4+ risk was genotyped, and plasma aβ42 and aβ40 were assayed. Cerebral amyloid burden was quantified using Florbetapir-PET scans. Baseline age was included as a covariate in all models.

Results:

Vascular risk significantly predicted cerebral amyloid burden in Alzheimer’s Disease Neuroimaging Initiative but not in the UCD-ADRC cohort. Cerebral amyloid burden was associated with plasma aβ 42/40 in both cohorts. Higher vascular risk increased cerebral amyloid burden was indirectly associated with reduced plasma aβ 42/40 in Alzheimer’s Disease Neuroimaging Initiative but not in UCD-ADRC cohort. However, when stratified by
APOE
ε4+ risk, we consistently observed this indirect relationship only in
APOE
ε4+ carriers across both cohorts.

Conclusions:

Vascular risk is indirectly associated with the level of plasma aβ 42/40 via cerebral amyloid burden only in
APOE
ε4+ carriers. Nondemented older adults with genetic vulnerability to dementia and accelerated decline may benefit from careful monitoring of vascular risk factors directly associated with cerebral amyloid burden and indirectly with plasma aβ 42/40.
The Computations Underlying Religious Conversion: A Bayesian Decision Model
Authors: Rigoli Francesco
Published: April 2023

Inspired by recent Bayesian interpretations about the psychology underlying religion, the paper introduces a theory proposing that religious conversion is shaped by three factors: (i) novel relevant information, experienced in perceptual or in social form (e.g., following interaction with missionaries); (ii) changes in the utility (e.g., expressed in an opportunity to raise in social rank) associated with accepting a new religious creed; and (iii) prior beliefs, favouring religious faiths that, although new, still remain consistent with entrenched cultural views (resulting in the phenomenon of syncretism). From the theory, a multifactorial picture of conversion emerges. Based on which factor is primarily engaged in each case, a classification of different types of conversion can be derived, with a remarkable fit with empirical literature. The theory offers a description of the processes underlying religious conversion and, highlighting the links among apparently incompatible previous views, it reconciles these views within a unifying framework.
Morphology of the larvae of Sandracottus femoralis Heller, 1934, and S. mixtus (Blanchard, 1843) and phylogenetic comparison with other known Aciliini (Coleoptera: Dytiscidae, Dytiscinae)
Authors: ALARIE YVES , MICHAT MARIANO C. , SHAVERDO HELENA , HÁJEK JIŘÍ
Published: April 2023

We describe the larvae of the diving-beetle genus Sandracottus Sharp, 1882 based on S. femoralis Heller, 1934 and S. mixtus (Blanchard, 1843). We include detailed morphometric and chaetotaxic analyses of the cephalic capsule, head appendages, legs, terminal abdominal segment and urogomphi in order to discover useful characters for distinguishing Sandracottus larvae from those of other known Aciliini (Coleoptera: Dytiscidae, Dytiscinae). A provisional parsimony analysis based on larval characteristics of seven Aciliini species in four genera (Acilius Leach, 1817, Graphoderus Dejean, 1833, Sandracottus, Thermonectus Dejean, 1833) was conducted using the program TNT. A clade grouping Eretini and Aciliini stands out as the most strongly supported in this analysis. The tribe Aciliini finds itself monophyletic with also very good support. Our analysis, however, failed to depict any clear phylogenetic relationships within the Aciliini although each of the four genera studied emerged from our study as morphologically distinct.
Integrative redescription of the sucking millipede genus Dawydoffia Attems, 1953, with a description of a new species and a transfer to the family Hirudisomatidae (Diplopoda, Polyzoniida)
Authors: WESENER THOMAS , MORITZ LEIF , AKKARI NESRINE
Published: April 2023

The type species of the monotypic Polyzoniida genus Dawydoffia Attems, 1953, D. kalonota Attems, 1953 from Vietnam, is redescribed based on type material. A second species of the genus, D. siphonocryptida n. sp., is described from Laos based on scanning electron microscopy, micro-computed tomography and molecular barcoding. The species of Dawydoffia are among the shortest and widest of the Polyzoniida, and resemble in habitus those of the Siphonocryptida genus Siphonocryptus Pocock, 1894, both having pleurites that are completely fused to the tergites. Dawydoffia was previously placed in the family Siphonotidae Cook, 1895, but can be identified as a member of the Holarctic Hirudisomatidae Silvestri, 1896 based on the following morphological characters: the uplifted posterior margins of the tergites, the collum covering part of the head, the position of the male gonapophysis or pseudopenis, the retracted telson, and the ozopores situated close to the tergal margin. However, both Dawydoffia species have a slender paronychium, a character previously known only from the Siphonotidae, but also documented here for Hirudisoma roseum (Victor, 1839). A slight redefinition of the Polyzoniida families is provided. The two Dawydoffia species differ in their coloration, as well as in their somatic and gonopodal characters.
Visualizing Uncertainty in Hurricane Forecasts with Animated Risk Trajectories
Authors: Witt Jessica K. , Labe Zachary M. , Warden Amelia C. , Clegg Benjamin A.
Published: April 2023

Hurricane forecasts are often communicated through visualizations depicting the possible future track of the storm. The cone of uncertainty (COU) is a commonly used visualization, but the graphic is prone to misinterpretation such as thinking only locations contained within the cone’s boundary are at risk. In this study, we investigated the utility of conveying hurricane forecast tracks using a set of animated icons, each representing an instance of a possible storm path. We refer to this new visualization as animated risk trajectories (ARTs). We measured nonexperts’ perception of risk when viewing simplified, hypothetical hurricane forecasts presented as ARTs or COUs. To measure perception of risk for each visualization type, we designed experiments to have participants make decisions to evacuate individual towns at varying distances from the most likely forecast path of a storm. The ARTs led to greater risk perception in areas that fell beyond the cone’s boundaries. Nonexperts’ interpretation of risk was impacted by the visual properties of the ARTs, such as the distribution of the icons, including their density, and whether the distribution was unimodal or bimodal. This supports the suggestion that ARTs can have value in communicating spatial–temporal uncertainty.

Significance Statement

Because of the inherent uncertainties in weather forecasts and emergency management planning, communicating hurricane risk to the public is a unique challenge for decision-makers. Our study investigated the effect of conveying uncertainty in hurricane forecast tracks using a distribution of animated icons [animated risk trajectories (ARTs)], which correspond to potential hurricane tracks that evolve over time. This visualization was compared with a simplified cone-of-uncertainty graphic, such as those used by the National Hurricane Center. We found that ARTs offered flexibility in conveying information about hurricane risk, such as the magnitude of the risk via the number of icons and the location of the risk via the distribution of icons.
Message or Messenger? Source and Labeling Effects in Authoritarian Response to Protest
Authors: Arnon Daniel , Edwards Pearce , Li Handi
Published: April 2023

Authoritarian regimes in the 21st century have increasingly turned to using information control rather than kinetic force to respond to threats to their rule. This paper studies an often overlooked type of information control: strategic labeling and public statements by regime sources in response to protests. Labeling protesters as violent criminals may increase support for repression by signaling that protests are illegitimate and deviant. Regime sources, compared to more independent sources, could increase support for repression even more when paired with such an accusatory label. Accommodative labels should have opposing effects—decreasing support for repression. The argument is tested with a survey experiment in China which labels environmental protests. Accusatory labels increase support for repression of protests. Regime sources, meanwhile, have no advantage over non-governmental sources in shifting opinion. The findings suggest that negative labels de-legitimize protesters and legitimize repression while the sources matter less in this contentious authoritarian context.
Quantifying lies in medical expert assessment
Authors: Golstein Marc A
Published: April 2023

Although lying is ubiquitous and present in all fields, there are very few medical references dealing with this subject. The aim of this study is to quantify and qualify lying in medical expert assessment. It is a retrospective study of 32 medical expert assessment cases, separated into two groups. The first analyses 16 people who were the subject of a judicial expert assessment. The second concerns a mandated consultant for insurances or mediation. The results appear to be influenced, essentially, in both groups, by the presence of an initial false diagnosis which is itself the main reason for the medical expert assessment, and by psychiatric disorders requiring treatment with psychotropic drugs. Intentional fraud appeared to be in the minority.
Characterizing fabric shape retention by sequential image analysis
Authors: Zhang Pengfei , Huang Zining , Zhou Qiantong , Wang Lei , Pan Ruru , Fei Yanna , Gao Weidong
Published: April 2023

Fabric shape retention is one of the most important attributes of fabrics that can influence the quality of the end use product. In this paper, we present a computer vision-based method to analyze the sequential images, which records the dynamic change of a deformed fabric, to model the recovery process, and extract the features of the recovery curve to characterize the shape retention after the deformation. Image processing and the perceptual hash algorithm were used to convert the measurements of a fabric shape variable at different times into Hamming distance points. The recovery function of the fabric shape was formed by fitting the Hamming distance points with exponential function, and three new shape retention indexes, that is, the average slope, the abscissa of the inflation point, and the radius of curvature at the inflation point, were defined based on the recovery function. The experiment showed that the shape retention of 12 fabric samples after deformation could be effectively distinguished by the new indexes. This paper also discussed the relationships between the new indexes and the transitional measurements indicating the fabric shape retention.
Health-related quality of life of women with breast cancer being treated with hormone therapy: A scoping review
Authors: Corpes Erilaine de F , Yanez Romel J V , Silva Denise M da , Leite Kauane M , Martins Milena C T , Vieira Milena M , Santos Cristina P R S dos , Fernandes Ana F C , Castro Régia C M B
Published: April 2023

Objective

To map the evidence available in the literature on the health-related quality of life of women with breast cancer using hormone therapy.

Data sources

This review followed the Joanna Briggs Institute methodological recommendations and Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews reporting guidelines. Searches were performed in nine databases using descriptors, synonyms and keywords; grey literature was also included. The review protocol was registered with the Open Science Framework under doi: http://doi.org/10.17605/OSF.IO/347FM . Inclusion criteria were established according to the Population, Concept, and Context strategy. The selection of studies was performed by two independent reviewers with the aid of RAYYAN software and disagreements were resolved by a third reviewer. The main information from the included articles was grouped into textual categories and presented by means of a narrative synthesis.

Data Summary

A total of 5419 records were identified, of which 42 studies fully met the eligibility criteria. Most were multicenter studies (42.9%) and randomized controlled trials (62%). Most studies addressed anastrozole (39.5%), letrozole (34.2%), and tamoxifen (26.3%), which were studied alone or in combination. The most widely used health-related quality-of-life assessment tool was the EORTC-QLQ-C30. The concomitant use of hormone therapy and cyclin-dependent kinase inhibitors 4 and 6 showed improvement in health-related quality of life.

Conclusion

In recent years there has been an increase in studies focused on health-related quality of life, and the evidence pointed to relevant information on health-related quality of life and the use of endocrine therapy, tamoxifen in combination with aromatase inhibitors, as well as aromatase inhibitor alone and the use of cyclin-dependent kinase 4 and 6.
Patterns and predictors of antidepressant prescribing among adults with cancer and depression in ambulatory care settings in the United States
Authors: Vadiei Nina , Le Alexander , Lopez Alfredo , Ponciano Anael , Smiley Desiree
Published: April 2023

Objective

Despite depression being a common comorbidity among adults with cancer, limited literature is available regarding pharmacologic depression treatment patterns and predictors in this population. This study aims to examine patterns and predictors of antidepressant prescribing among adults with cancer and depression in ambulatory care settings in the United States (US).

Methods

This retrospective, cross-sectional study utilized data collected from the 2014 to 2015 National Ambulatory Medical Care Survey (NAMCS). The study sample consisted of adults (age ≥ 18 years) with cancer and depression (unweighted N = 539; weighted N = 11,361,000). A multivariable logistic regression analysis was used to adjust for individual-level factors to identify predictors of antidepressant prescribing.

Results

Most patients were adults aged ≥ 65 years, female, and non-Hispanic whites. Thirty-seven percent of the study sample received antidepressant treatment. Multivariable logistic regression analysis revealed that race/ethnicity, physician specialty, and number of medications were significantly associated with receiving antidepressant(s). For example, non-Hispanic whites were two-and-half times more likely to receive an antidepressant [OR 2.43, 95% confidence interval 1.13–5.23] compared to other race/ethnic groups. Every unit increase in the number of prescribed medications increased the likelihood of receiving an antidepressant by 6% (OR 1.06, 95% CI: 1.01–1.11).

Conclusion

Among adults with a comorbid cancer and depression diagnosis and a recorded U.S. ambulatory care visit in 2014–2015, 37% received antidepressant treatment. This suggests most patients with cancer and depression do not receive pharmacologic treatment for depression. Future studies are needed to investigate the impact of antidepressant treatment on health outcomes in this patient population.
Influence of Non-uniform Parameter of Bolt Joint on Complexity of Frequency Characteristics of Cylindrical Shell
Authors: Tang Qiansheng , She Houxin , Li Chaofeng , Wen Bangchun
Published: April 2023

Bolt connection is one of the main fixing methods of cylindrical shell structures. A typical bolted connection model is considered as a tuned system. However, in the actual working conditions, due to the manufacturing error, installation error and uneven materials of bolts, there are always random errors between different bolts. To investigate the influence of non-uniform parameters of bolt joint, including the stiffness and the distribution position, on frequency complexity characteristics of cylindrical shell through a statistical method is the main aim of this paper. The bolted joints considered here were simplified as a series of springs with random features. The vibration equation of the bolted joined cylindrical shell was derived based on Sanders’ thin shell theory. The Monte Carlo simulation and statistical theory were applied to the statistical analysis of mode characteristics of the system. First, the frequency and mode shape of the tuned system were investigated and compared with FEM. Then, the effect of the random distribution and the random constraint stiffness of the bolts on the frequency and mode shape were studied. And the statistical analysis on the natural frequencies was evaluated for different mistuned levels. And some special cases were presented to help understand the effect of random mistuning. This research introduces random theory into the modeling of bolted joints and proposes a reference result to interpret the complexity of the modal characteristics of cylindrical shells with non-uniform parameters of bolt joints.
Pre-research on Enhanced Heat Transfer Method for Special Vehicles at High Altitude Based on Machine Learning
Authors: Li Chunming , Sun Xiaoxia , Gao Hongyang , Zhang Yu
Published: April 2023

The performance of an integrated thermal management system significantly influences the stability of special-purpose vehicles; thus, enhancing the heat transfer of the radiator is of great significance. Common research methods for radiators include fluid mechanics numerical simulations and experimental measurements, both of which are time-consuming and expensive. Applying the surrogate model to the analysis of the flow and heat transfer in louvered fins can effectively reduce the computational cost and obtain more data. A simplified louvered-fin heat transfer unit was established, and computational fluid dynamics (CFD) simulations were conducted to obtain the flow and heat transfer characteristics of the geometric structure. A three-factor and six-level orthogonal design was established with three structural parameters: angle θ, length a, and pitch Lp of the louvered fins. The results of the orthogonal design were subjected to a range analysis, and the effects of the three parameters θ, a, and Lp on the j, f, and JF factors were obtained. Accordingly, a proxy model of the heat transfer performance for louvered fins was established based on the artificial neural network algorithm, and the model was trained with the data obtained by the orthogonal design. Finally, the fin structure with the largest JF factor was realized. Compared with the original model, the optimized model improved the heat transfer factor j by 2.87%, decreased the friction factor f by 30.4%, and increased the comprehensive factor JF by 15.7%.
CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study
Authors: Cai Nan , Li Cunren , Gu Xianfang , Zeng Wenfeng , Zhong Jiawei , Liu Jingfeng , Zeng Guopeng , Zhu Junxing , Hong Haifeng
Published: April 2023

Background

Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population.

Methods

The study included 1,872 hypertensive patients and 1,110 controls. The genotypes ofCYP2C19rs4244285 and rs4986893 of all individuals were detected and analyzed.

Results

The genotype and allele distributions ofCYP2C19rs4244285 were significantly different between hypertension group and control group. TheCYP2C19*1/*1 genotype was the most predominant among the subjects (40.8%), followed by theCYP2C19*1/*2 genotype (40.5%). The percentage ofCYP2C19*1, *2, and *3 allele was 64.2%, 30.8%, and 5.0%, respectively. The proportion of intermediate metabolizers (IM) (49.3% vs. 42.9%), poor metabolizers (PM) (14.3% vs. 8.9%) (P < 0.001), andCYP2C19*2 allele (33.8% vs. 25.7%,P < 0.001) in hypertension group was significantly higher than that in control group. Multivariate logistic regression (adjusted for gender, age, smoking, and drinking) indicated thatCYP2C19*1/*2, *1/*3, and *2/*2 genotypes may increase susceptibility to hypertension. And theCYP2C19IM genotype (IM vs. EM: OR 1.514, 95% CI: 1.291–1.775,P < 0.001), PM genotype (PM vs. EM: OR 2.120, 95% CI: 1.638–2.743,P < 0.001), IM + PM genotypes (IM + PM vs. EM: OR 1.617, 95% CI: 1.390–1.882,P < 0.001) may increase risk of hypertension.

Conclusions

CYP2C19loss-of-function (IM, PM genotypes) is independent risk factor for hypertension susceptibility. Specifically, the risk genotypes includeCYP2C19*1/*2, *1/*3, and *2/*2.
Factors affecting the immunogenicity of influenza vaccines in human
Authors: Xu Qiuyi , Wei Hejiang , Wen Simin , Chen Jiamin , Lei Yuxuan , Cheng Yanhui , Huang Weijuan , Wang Dayan , Shu Yuelong
Published: April 2023

Background

The influenza viruses pose a threat to human health and medical services, and vaccination is an important way to prevent infection. However, the effectiveness of influenza vaccines is affected by various aspects. This study aimed to explore factors related to the immune response to influenza vaccines.

Methods

The study was conducted from September 2019 to September 2021, and a total of 593 volunteers were recruited from the Center for Disease Control and Prevention in 3 provinces in China. The hemagglutination inhibition assay was used to measure antibody levels. The Chi-square test, multivariable logistic regression analysis, and sum-rank test were used to analyze the factors associated with influenza vaccine immune response.

Results

The Chi-square test showed that seroconversion rates and response rate were associated with age group, vaccination history, chronic conditions, the frequency of colds, and region (P < 0.05). The multivariable logistic regression analysis showed that age was an important factor that affected participants’ seroconversion rates for A/H1N1, A/H3N2, B/Victoria, and response status (18–64 vs. ≤5: OR = 2.77, P < 0.001; ≥65 vs. ≤5: OR = 0.38, P = 0.01; 18–64 vs. ≤5: OR = 2.64, P = 0.03). Vaccination history was also an affecting factor for A/H1N1, B/Victoria, and response status (yes vs. no: OR = 0.4 / 0.44 / 0.25, P < 0.001). The frequency of colds and chronic conditions were also affecting factors for participants’ seroconversion rates and response levels to different degrees. The sum-rank test showed that the fold changes for A/H1N1, B/Victoria, and B/Yamagata were associated with age group and vaccination history (P < 0.01). The fold changes for A/H3N2 were associated with the frequency of colds (P < 0.05), and those for B/Victoria were associated with gender and chronic conditions (P < 0.05).

Conclusions

Vaccination history, age, health condition, and frequency of colds were important factors affecting the seroconversion rate of the influenza vaccine in human. There is a need for developing optimized vaccination strategies for vulnerable groups to improve the efficacy of influenza vaccines in human.
Nocardia caishijiensis infection: a case report and review of the literature
Authors: Malaguez Webber Fabricio , Nachiappan Arun , Lau Freddy Duarte , Costello Christie , Zane Saul
Published: April 2023

Background

Nocardia caishijiensis is a rare soil actinomycete first described in Anhui province, China, in 2003. There has been only one reported instance of human infection caused by this species in the current literature.

Case presentation

We present a case of pulmonary nocardiosis caused by Nocardia caishijiensis in a fifty-two-year-old man with human immunodeficiency virus infection and concomitant use of high-dose dexamethasone for cervical myelopathy, treated successfully with amikacin and thrimetroprim-sulfametoxazole, antibiotic resistance pattern was obtained, although interpretation may be limited.

Conclusion

To our knowledge, this is the first reported case of Nocardia caishijiensis infection in humans in North America and the second one in the literature, this pathogen should be recognized as a potentially rising etiology of nocardiosis, especially in solid organ transplant recipients. This has a rising importance as the survival for solid organ recipients continue to rise with advance in transplant medicine leading to increased life expectancy in this particularly susceptible group.
Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review
Authors: Chen Ning-Xin , Wang Ming-Liang , Wang Hai-Xing , Zeng Meng-Su
Published: April 2023

Objective

The purpose of this study was to evaluate the CT and MRI findings, clinicopathologic features, and differential diagnosis of Sclerosing angiomatoid nodular transformation (SANT).

Methods and materials

Seven men and seven women with pathological diagnoses of SANT were included in this retrospect study. Patients underwent at least one radiological examination before surgery. The number, shape, margin, size, attenuation, signal intensity, homogeneity, and enhancing pattern of the lesion were evaluated by two abdominal radiologists independently. Immunohistochemistry reports were available for 11 patients. The immunoreactivity to the vascular markers CD8, CD31, and CD34 was assessed.

Results

The 14 SANT patients (7 men, 7 women; mean age, 43.5 years; age range, 24–56 years) presented with a single lesion and showed no specific clinical symptoms. Among 14 patients, 12 patients underwent MR scan, 5 patients underwent CT scan and 3 patients underwent PET-CT. On CT, all 5 lesions showed hypodensity on non-contrast images and spoke-wheel enhancing pattern after contrast administration, and calcification was observed. On T2WI, 10 cases(83.3%)showed hypointensity and 2 cases (16.7%) showed hyperintensity with central hypointensity. On T1WI, 10 cases (83.3%) were isointense and 2 cases (16.7%) were slightly hypointense. 10 cases (83.3%) showed hypointensity on DWI and 2 cases (16.7%) showed slightly hyperintensity on DWI. After contrast administration, all 12 lesions showed progressive enhancement. 18 F-fluorodeoxyglucose (FDG) uptake in the tumor was seen in all three cases that underwent PET-CT. The maximum standardized uptake value (SUVmax) was 4.5, 5.1, and 3.8 respectively.

Results

Apart from the progressive spoke-wheel enhancing pattern, DWI and ADC findings will add value to the diagnosis of SANT.
Texting for life: a mobile phone application to connect pregnant women with emergency transport and obstetric care in rural Nigeria
Authors: Okonofua Friday , Ntoimo Lorretta , Johnson Ermel , Sombie Issiaka , Ojuolape Solanke , Igboin Brian , Imongan Wilson , Ekwo Chioma , Udenigwe Ogochukwu , Yaya Sanni , Wallis Anne B. , Adeniran Joy
Published: April 2023

Background

Difficulty in transportation to access skilled providers has been cited repeatedly as a major barrier to utilization of emergency obstetric care in Nigeria.

Objective

The objective of this paper is to describe the design, implementation, and outcomes of a mobile phone technology aimed at rapidly reaching rural Nigerian women who experience pregnancy complications with emergency transportation and access to providers.

Method

The project was implemented in 20 communities in two predominantly rural Local Government Areas (LGAs) of Edo State, in southern Nigeria, as part of a larger implementation project aimed at improving the access of rural women to skilled pregnancy care. The digital health innovation named Text4Life, allowed women to send a brief message from their mobile phone to a server linked to Primary Health Care (PHC) facilities and to access pre-registered transport owners. Pregnant women were registered and taught to text short messages to a server from their mobile phones or those of a friend or relative when they experience complications.

Results

Over 18 months, 56 women out of 1620 registered women (3.5%) texted the server requesting emergency transportation. Of this number, 51 were successfully transported to the PHC facilities, 46 were successfully treated at the PHC, and five were referred to higher-level care facilities. No maternal deaths occurred during the period, while four perinatal deaths were recorded.

Conclusion

We conclude that a rapid short message sent from a mobile phone to a central server and connected to transport providers and health facility managers is effective in increasing the access of pregnant women to skilled emergency obstetric services in rural Nigeria.
Clinical benefit of subsequent chemotherapy after drug-induced interstitial lung disease in pancreatic cancer patients: a multicenter retrospective study from Japan
Authors: Irie Hiroki , Suzuki Rei , Okubo Yoshinori , Asama Hiroyuki , Konno Naoki , Noguchi Yuki , Watanabe Ko , Shibukawa Goro , Imamura Hidemichi , Takagi Tadayuki , Sugimoto Mitsuru , Sato Yuki , Nakamura Jun , Kato Tsunetaka , Hashimoto Minami , Yanagita Takumi , Hikichi Takuto , Ohira Hiromasa
Published: April 2023

Purpose

Drug-induced interstitial lung disease (ILD) is not a rare adverse event in the current chemotherapy strategy for pancreatic ductal adenocarcinoma (PDAC). Thus, we aimed to find the optimal management for PDAC patients with a history of ILD induced by a gemcitabine-based regimen.

Methods

We conducted a multicenter retrospective study. The primary endpoint was the overall survival (OS) of patients who underwent either S-1 monotherapy or FOLFOX after the onset of ILD. Toxicity data was also analyzed in the 2 groups.

Results

Twenty-four patients were diagnosed with ILD and 17 patients who received subsequent chemotherapy were enrolled in the study. Among 17 patients who were managed with subsequent chemotherapy after recovering from ILD, we did not observe significant difference in OS between S-1 and FOLFOX (290.0 days vs. undefined, p = 0.39). Relapse of drug-induced ILD was not observed in all cases during the course. Overall, severe adverse events (CTCAE Grade 3 or 4) were observed in 3 patients (23.1%) in S-1 treatment group and 1 patient (25.0%) in FOLFOX treatment group (p = 0.93).

Conclusions

S-1 monotherapy and FOLFOX are comparable as the subsequent chemotherapy after gemcitabine-based chemotherapy-induced ILD in unresectable PDAC.
Elemental profiles in distant tissues during tumor progression
Authors: Salles Samella , Salles Rebecca , Pavão Mauro S. G. , Cardoso Simone C. , Stelling Mariana P.
Published: April 2023

Background

Essential elements have functions in tumor progression by promoting protumoral cellular processes, such as proliferation, and migration, among others. Obtaining an understanding of how these elements relate to tumor progression processes is of great importance for research. Elemental profile studies in distant tissues, which can be modulated by tumor cells to promote metastasis, have not been sufficiently investigated. The main goal of this study is to evaluate multielemental distribution during tumor progression, focusing on tumor tissue and distant tissues that may be affected.

Methods

Tumor progression in vivo was simulated by inoculating C57BL/6 mice with Lewis Lung Carcinoma (LLC) cells. Samples of the primary tumor and distant tissues were collected during 5 weeks of tumor progression for the control and experimental (tumor-bearing) groups. The biological samples were analyzed using the synchrotron radiation X-Ray fluorescence technique. Data on the concentration of P, S, K, Ca, Mn, Fe, Cu, and Zn in the samples were obtained and statistically analyzed to evaluate the distribution of the elements during tumor progression in the primary tumor as well as distant tissues.

Results

It was possible to observe significant changes in the concentrations’ distribution of P, S, K, Ca, Mn, Fe, and Cu in distant tissues caused by the presence of tumor cells. It was also possible to detect a greater similarity between tumor tissue (which has the lung as tissue of origin) and a tissue of non-origin, such as the liver, which is an unprecedented result. Moreover, changes in the distributions of concentrations were detected and studied over time for the different tissues analyzed, such as primary tumor, liver and lung, in Control and Tumor groups.

Conclusions

Among other results, this paper could explore the modulation of distant tissues caused by the presence of a primary tumor. This could be achieved by the evaluation of several elements of known biological importance allowing the study of different biological processes involved in cancer. The role of essential elements as modulators of the tumor microenvironment is a relevant aspect of tumor progression and this work is a contribution to the field of tumoral metallomics.
First-line atezolizumab/durvalumab plus platinum–etoposide combined with radiotherapy in extensive-stage small-cell lung cancer
Authors: Li Lijuan , Yang Dan , Min Yanmei , Liao Anyan , Zhao Jing , Jiang Leilei , Dong Xin , Deng Wei , Yu Huiming , Yu Rong , Zhao Jun , Shi Anhui
Published: April 2023

Background

Immunotherapy has made significant advances in the treatment of extensive-stage small-cell lung cancer (ES-SCLC), but data in combination with radiotherapy are scarce. This study aims to assess the safety and efficacy of chemoimmunotherapy combined with thoracic radiotherapy in patients with ES-SCLC.

Methods

This single-center retrospective study analyzed patients with ES-SCLC who received standard platinum–etoposide chemotherapy combined with atezolizumab or durvalumab immunotherapy as induction treatment, followed by consolidative thoracic radiotherapy (CTRT) before disease progression in the first-line setting. Adverse events during radiotherapy with or without maintenance immunotherapy and survival outcomes were assessed.

Results

Between December 2019 and November 2021, 36 patients with ES-SCLC were identified to have received such treatment modality at one hospital. The number of metastatic sites at diagnosis was 1–4. The biological effective dose of CTRT ranged from 52 to 113 Gy. Only two patients (6%) developed grade 3 toxic effect of thrombocytopenia, but none experienced grade 4 or 5 toxicity. Four patients developed immune-related pneumonitis during the induction treatment period but successfully completed later CTRT. The rate of radiation-related pneumonitis was 8% with grades 1–2 and well tolerated. The median progression-free survival (PFS) was 12.8 months, but the median overall survival (OS) was not determined. The estimated 1-year OS was 80.2% and 1-year PFS was 53.4%.

Conclusions

Immunotherapy combined with CTRT for ES-SCLC is safe and has ample survival benefit.
Efficacy and safety of transurethral resection of bladder tumour combined with chemotherapy and immunotherapy in bladder-sparing therapy in patients with T1 high-grade or T2 bladder cancer: a protocol for a randomized controlled trial
Authors: Yang Xiangwei , Zhang Shiqiang , Cui Yajiao , Li Yamei , Song Xinyue , Pang Jun
Published: April 2023

Background

Bladder cancer is the tenth most common cancer worldwide. For patients with T1 high-grade or T2 bladder cancer, radical cystectomy is recommended. However, radical cystectomy is associated with various complications and has a detrimental impact on the quality of life. Bladder-sparing therapy has been widely explored in patients with muscle-invasive bladder cancer, and whether a combination of transurethral resection of bladder tumour (TURBT) with chemotherapy and immunotherapy shows definite superiority over TURBT plus chemotherapy is still a matter of debate. The aim of this study is to investigate the efficacy and safety of TURBT combined with chemotherapy and immunotherapy in bladder-sparing therapy in patients with T1 high-grade or T2 bladder cancer who are unwilling or unsuitable to undergo radical cystectomy.

Methods

An open-label, multi-institutional, two-armed randomized controlled study will be performed with 86 patients with T1 high-grade or T2 bladder cancer meeting the eligibility criteria. Participants in the experimental group (n = 43) will receive TURBT combined with chemotherapy (GC: gemcitabine 1000 mg/m2 on the 1st day and the 8th day, cisplatin 70 mg/m2 on the 2nd day, repeated every 21 days) and immunotherapy (toripalimab 240 mg on the 5th day, repeated every 21 days), and those in the control group (n = 43) will receive TURBT plus chemotherapy (GC). The primary outcome is pathological response, and the secondary outcomes include progression-free survival, overall survival, toxicities, and quality of life.

Discussion

To the best of our knowledge, this is the first study to evaluate the efficacy and safety of TURBT combined with GC regimen and toripalimab in bladder-sparing therapy in patients with T1 high-grade or T2 bladder cancer. The expected benefit is that the combination of TURBT with chemotherapy and immunotherapy would be more effective than TURBT plus chemotherapy without compromising the quality of life and increasing the toxicity.

Trial registration

ChiCTR2200060546, chictr.org.cn, registered on June 14, 2022.
Bacillary layer detachment with malignant choroidal tumors: a case series
Authors: Fouad Yousef Ahmed , Salman Abdelrahman Gaber , Ashour Doaa Maamoun , Elkady Mohamed Sabry , Abdel-khalek Noha , Nowara Mohamed , Ebeid Weam Mohamed
Published: April 2023

Purpose

To study the incidence and characteristics of bacillary layer detachment (BALAD) occurring with the two most common choroidal malignancies, choroidal metastasis and choroidal melanoma.

Methods

A retrospective multicentric record analysis. Eyes with a diagnosis of choroidal melanoma or choroidal metastasis that had good-quality fundus photography and spectral domain optical coherence tomography (OCT) scans of the macular and tumor regions allowing for delineation of the retinal layers were included for analysis. Qualitative image evaluation was done by two independent graders for the presence, location, and OCT features of BALAD, as well as any associated intraretinal or subretinal fluid. Demographic and clinical data were also retrieved.

Results

Of the 11 eyes with choroidal metastasis and 7 eyes with choroidal melanoma that were included in the final analysis, 6 (54.5%) and 1 (14.3%) had BALAD, respectively. The BALAD co-localized with the subretinal fluid in all cases and with the intraretinal fluid in 1/3 cases (33.3%), was foveal in location in 3 eyes (42.9%), was overlying the tumor in 6 eyes (85.7%), and varied in number and size. Reflectivity within the BALAD was consistently higher than the vitreous and adjacent subretinal fluid, and discernable suspended hyperreflective particles were noted in 5 eyes (71.4%).

Conclusion

BALAD is relatively common with choroidal metastasis. The OCT features described supplement our recognition of this new entity.
The association between fasting plasma glucose variability and incident eGFR decline: evidence from two cohort studies
Authors: Deravi Niloofar , Sharifi Yasaman , Koohi Fatemeh , Zadeh Seyed Saeed Tamehri , Masrouri Soroush , Azizi Fereidoun , Hadaegh Farzad
Published: April 2023

Background

Glycemic variability (GV) is developing as a marker of glycemic control, which can be utilized as a promising predictor of complications. To determine whether long-term GV is associated with incident eGFR decline in two cohorts of Tehran Lipid and Glucose Study (TLGS) and Multi-Ethnic Study of Atherosclerosis (MESA) during a median follow-up of 12.2 years.

Methods

Study participants included 4422 Iranian adults (including 528 patients with T2D) aged ≥ 20 years from TLGS and 4290 American adults (including 521 patients with T2D) aged ≥ 45 years from MESA. The Multivariate Cox proportional hazard models were used to assess the risk of incident eGFR decline for each of the fasting plasma glucose (FPG) variability measures including standard deviation (SD), coefficient of variation (CV), average real variability (ARV), and variability independent of the mean (VIM) both as continuous and categorical variables. The time of start for eGFR decline and FPG variability assessment was the same, but the event cases were excluded during the exposure period.

Results

In TLGS participants without T2D, for each unit change in FPG variability measures, the hazards (HRs) and 95% confidence intervals (CI) for eGFR decline ≥ 40% of SD, CV, and VIM were 1.07(1.01–1.13), 1.06(1.01–1.11), and 1.07(1.01–1.13), respectively. Moreover, the third tertile of FPG-SD and FPG-VIM parameters was significantly associated with a 60 and 69% higher risk for eGFR decline ≥ 40%, respectively. In MESA participants with T2D, each unit change in FPG variability measures was significantly associated with a higher risk for eGFR decline ≥ 40%.Regarding eGFR decline ≥ 30% as the outcome, in the TLGS, regardless of diabetes status, no association was shown between FPG variability measures and risk of eGFR decline in any of the models; however, in the MESA the results were in line with those of GFR decline ≥ 40%.Using pooled data from the two cohorts we found that generally FPG variability were associated with higher risk of eGFR decline ≥ 40% only among non-T2D individuals.

Conclusions

Higher FPG variability was associated with an increased risk of eGFR decline in the diabetic American population; however, this unfavorable impact was found only among the non-diabetic Iranian population.
Heterogeneous uptake of 18F-FDG and 18F-PSMA-1007 PET/CT in lung cancer and lymph node metastasis
Authors: Hu Yuan , Wang Peng , Dai Wenli
Published: April 2023

Background

PSMA PET/CT has shown excellent results in imaging of prostate cancer. However, some nonprostatic malignancies can also demonstrate 18 F-PSMA uptake, including primary lung cancer. 18 F-FDG PET/CT is widely employed in initial staging, response to therapy and follow-up assessment for lung cancer. Here we present an interesting case report on the different patterns of PSMA and FDG uptake between primary lung cancer and metastatic intrathoracic lymph node metastases in a patient with concurrent metastatic prostate cancer.

Case presentation

A 70-year-old male underwent 18 F-FDG PET/CT and 18 F-PSMA-1007 PET/CT imaging due to suspicion primary lung cancer and prostate cancer. The patient eventually was diagnosed with non-small cell lung cancer (NSCLC) with mediastinal lymph node metastases and prostate cancer with left iliac lymph node and multiple bone metastases. Interestingly, our imaging revealed different patterns of tumor uptake detected on 18 F-FDG and 18 F-PSMA-1007 PET/CT in primary lung cancer and lymph node metastases. The primary lung lesion showed intense FDG uptake, and mild uptake with 18 F-PSMA-1007. Whereas the mediastinal lymph node metastases showed both intense FDG and PSMA uptake. The prostate lesion, left iliac lymph node, and multiple bone lesions showed significant PSMA uptake and negative FDG uptake.

Conclusion

In this case, there was a homogeneity of 18 F-FDG intense uptake between LC and metastatic lymph nodes, but a heterogeneity in 18 F-PSMA-1007 uptake. It illustrated that these molecular probes reflect the diversity of tumor microenvironments, which may help us understand the differences of the tumor response to treatment.
Uretero-neocystostomy: a retrospective comparison of open, laparoscopic and robotic techniques
Authors: Ramesmayer Christian , Pallauf Maximilian , Gruber Ricarda , Kunit Thomas , Oswald David , Lusuardi Lukas , Mitterberger Michael
Published: April 2023

Background

Uretero-neocystostomy (UNC) is the gold-standard for distal-ureter repair. Whether the surgery should be conducted minimally invasive (laparoscopic (LAP), robotic RAL)) or open remains unanswered by the literature.

Methods

Retrospective analysis of surgical outcome of patients treated with UNC for distal ureteral stenosis (January 2012 - October 2021). Patient demographics, estimated blood loss (EBL), surgical technique, operative time, complications and length of hospital stay (LOS) were recorded. During the follow-up period, patient underwent renal ultrasound and kidney function tests. Success was defined as relieve of symptoms or no findings of obstruction needing urine drainage.

Results

60 patients were included (9 RAL, 25 LAP, 26 open). The different cohorts were similar of age, gender, American Society of Anesthesiologists (ASA) score, body-mass index and history of prior treatment of the ureter. No intraoperative complications were detected in all groups. There was no conversion to open surgery in the RAL group, whereas one was found in the LAP arm. Six patients had a recurrent stricture, but with no significant difference between the cohorts. EBL was not different between the groups. LOS was significantly lower in the RAL + LAP group compared to open (7 vs. 13 days, p = 0.005) despite significantly longer operating times (186 vs. 125.5 min, p = 0.005).

Conclusion

Minimal invasive UNC, especially RAL, is a feasible and safe surgical method and provides similar results in terms of success rates in comparison to open approach. A shorter LOS could be detected. Further prospective studies need to be done.