bluuebunny/crossref_metadata_2025 huggingface dataset:
Changing the main chemical compounds of the tea leaf
Authors:   Kuban State Technological University, Krasnodar, Vasilieva A.N. , Tatarchenko I.I. ,   Kuban State Technological University, Krasnodar, Dubrovskaya I.A. ,   Kuban State Technological University, Krasnodar, Baranova Z.A. ,   Kuban State Technological University, Krasnodar
Published: August 2022

Chromatographic analysis of tea fatty acids was carried out on a hardware-software complex based on the Chromatek-Crystal 5000 chromatograph (Russia). In the composition of tea fatty acids, oleic acid (35.56%) accounts for the maximum amount, and palmitic (24.60%) and linoleic (21.74%) acids are contained in significant quantities. Organoleptic analyses determine the quality of tea according to five quality indicators: appearance, intensity of the infusion, aroma, taste, and color of the boiled leaf.
Advertising in the hospitality industry and modern methods of promoting hotel services
Authors:   Moscow State University of Sports and Tourism, Osmolovskaya О. , Umarova D. ,   Moscow State University of Sports and Tourism, Ushakov R. N. ,   Moscow State University of Sports and Tourism
Published: August 2022

The article shows the distinctive features of advertising in the hotel business, identified types of advertising in the industry. It is concluded that in order to create effective hotel advertising, it is necessary to be able to take into account the specifics of the industry and combine several aspects of such advertising into a single complex.
To the question of digitalization of hotel and tourist business in Russia
Authors:   Hotel Business and Tourism InstituteиPeoples’ Friendship University of Russia, Karpljuk M. , Bogomolova E. S. ,   Hotel Business and Tourism InstituteиPeoples’ Friendship University of Russia
Published: August 2022

This article discusses the process of digitalization, the introduction of innovative technologies in the structure of the hotel and tourism business, the main trends and advantages of digitalization, the main difficulties of transition to a digital environment. Particular attention is paid to the development of digitalization in the field of hospitality in Russia.
Impact of Management Information Systems on Hotel Management
Authors:   Damascus University, Syrian Arab Republic, Makhlouf Aghiad
Published: August 2022

This scientific study is aimed at determining the impact of management information systems and information technologies in general on management and work in a hotel in terms of productivity, in particular, since it explores the reality of the extent to which information systems are used in hotel enterprises and their impact on work and the extent to which they contribute to the improvement and application of management concepts, starting with planning, organization, control and their reflection on the production performance of the hotel.
Prospects for the development of ecological tourism in the Сrimea
Authors:   Moscow State University of Sports and Tourism, Zubareva A. I. , Tolmacheva K. V. ,   Moscow State University of Sports and Tourism, Ushakov R. N. ,   Moscow State University of Sports and Tourism
Published: August 2022

This article shows the current state and prospects of green tourism in the Crimea. Tourism is one of the main sectors of the economy that fills the budget of the Crimea. The development of rural, ecological and ethnographic types of tourism in the Crimea can solve many problems associated with the territorial, economic organization of leisure.
Importancia de las plataformas virtuales para la investigación de marketing en tiempos de COVID-19
Authors: Naranjo Bert Irina , Moscoso Merchán Marco , Andrade Sarmiento Bolívar
Published: August 2022

En una era marcada por la comunicación, la información y la incertidumbre, las plataformas digitales constituyen una herramienta de gran importancia en todos los ámbitos de la sociedad, en especial en el campo de la competitividad empresarial y el Marketing. Siendo los canales por excelencia para obtención de información relevante en función de la toma de decisiones acertadas. En el presente estudio se analizó el uso eficiente de las plataformas digitales aplicadas a la Investigación de Mercados en tiempos de pandemia. Se empleó la técnica de revisión bibliográfica y el análisis documental. Se seleccionaron dieciocho publicaciones científicas generadas en los últimos diez años evidencia las transformaciones tecnológicas sobre la vida humana, cambiando la forma de relacionarse, comerciar e interactuar. Concluyendo que la dinámica social generada a partir de la pandemia por el COVID-19 ha facilitado el camino a las empresas en la búsqueda de información y datos importantes para conocer el comportamiento de diversos fenómenos del entorno.
Oğuzeli Ağzında Kullanılan Deyimler Üzerine Bir İnceleme
Authors: GÜVEN Ömer , YALNIZ Asena
Published: August 2022

Deyimler, anlatıma canlılık ve akıcılık katmaları bakımından dilin söz varlığı içinde önemli bir yere sahiptir. Türkçe, deyimler bakımından zengin bir dildir. Orhun Yazıtlarından itibaren yazılı metinlerle takip edilebilen Türk dili, bu tarihî seyri içinde pek çok deyim üretmiştir. Bu deyimlerin kullanıldığı yerlerden biri de Türkiye Türkçesi ağızlarıdır. Türkiye Türkçesi ağızlarında kayda alınmayı bekleyen birçok deyim yapılan kısıtlı çalışmada tespit edilmiştir. Başta teknolojik gelişmeler olmak üzere pek çok nedenle ağızlarda yer alan söz varlığı yok olma tehlikesiyle karşı karşıyadır. Bu sebeple Türkiye Türkçesi ağızları ile ilgili söz varlığının tespiti ve kayıt altına alınması oldukça önemlidir. Bu çalışmada Oğuzeli ağzında kullanılan ancak standart Türkçede yer almayan deyimler ele alınmıştır. Oğuzeli ve köylerinden yapılan derlemeler ile tespit edilen deyimler üzerinde çeşitli tasnifler yapılmıştır. İlk olarak belirlenen deyimler Köken Bakımından ele alınmıştır. İkinci olarak deyimler Söz Dizimi ve Şekil Bilgisi Bakımından değerlendirilmeye tabi tutulmuştur. Son olarak ise Anlam Bakımından deyimlerin sınıflandırılması yapılmıştır. Bu sınıflandırma çalışmalarının ardından derlenen bütün deyimler alfabetik olarak sıralanmış ve deyimlerin anlamları verilmiştir.
Kahve Hakkında Yazılmış Manzum Bir Fetva Örneği
Authors: NALBAT Muhammet
Published: August 2022

Osmanlı toplumu kahve ile 16. yüzyılda tanışmıştır. Bu tanışma, uzun sürecek dinî ve toplumsal bir tartışmanın başlangıcı olmuştur. Osmanlı din âlimleri arasında, haram ya da helal kabul edilmesi noktasında uzun süre tartışılan kahve, bu yönüyle manzum fetvalara da konu olmuştur. Bu makalede, kahve hakkında yazılmış manzum bir fetva örneği incelenmiştir. Müellifi tam olarak tespit edilemeyen ancak Osmanlı ulemasının kahveye bakışını yansıtan bu manzume, manzum fetva geleneği içinde ele alınarak değerlendirilmiştir. Kahve hakkında genel bir bilginin verildiği “Giriş” bölümünden sonra makalenin “1. Bölüm”ünde, kahvenin Osmanlı toplumuna girişi ve ulemanın kahveye verdiği tepkiler irdelenmiştir. “2. Bölüm”de, Klasik Türk edebiyatı bağlamında manzum fetva geleneği genel hatları ile ele alınmıştır. Makalenin “3. Bölüm”ünde, bu yazıya konu olan Manzum Kahve Fetvası’nın yer aldığı yazma tanıtılmıştır. Daha sonraki bölümde, Manzum Kahve Fetvası, şekil ve muhteva bakımından incelenmiştir. Makalenin son bölümünde ise söz konusu fetvanın transkripsiyonlu metnine yer verilmiştir. Böylece kahve hakkında yazılmış bu manzum fetva örneği, araştırmacıların dikkatine sunulmuştur.
ÇOCUKLARDA BRUKSİZM İLE İSKELETSEL ANOMALİLER ARASINDAKİ İLİŞKİNİN SEFALOMETRİK ANALİZLER KULLANILARAK DEĞERLENDİRİLMESİ
Authors: TOPSAKAL Kübra Gülnur , SOLAK KOLCAKOGLU Kevser , AKSOY Merve
Published: August 2022

Bruksizm çocuklarda uyku veya uyanıklık halinde görülen, çiğneme kaslarındaki aşırı kontraksiyona bağlı olarak temporo mandibular eklem disfonksiyonuna ve dişlerde aşınmaya neden olabilecek parafonksiyonel bir alışkanlıktır. Bu çalışmanın amacı, bruksizmli çocukların iskeletsel ve dişsel malokluzyonları ile bruksizm arasındaki ilişkinin değerlendirilmesidir. Çalışmaya Erciyes Üniversitesi Diş Hekimliği Fakültesi’ne başvuran ve bruksizm tanısı alan yaşları 5 ile 14 arasında değişen toplam 25 hasta (10 erkek ve 15 kız) dahil edilmiştir. Çalışmaya katılan bruksizmli bireylerin yaş ortalaması 11.6±5.5 ay iken bu değerler erkekler için 10.5±4.9, kızlar için ise 11.3±2.9 dur. Temporomandibular eklem rahatsızlığı olanlar, sistemik rahatsızlığı olanlar, fasiyalasimetrisi bulunanlar, kraniofasiyal travma, cerrahi operasyon geçirenler ile medical ilaç tedavisi alanlar ise çalışmaya dahil edilmemiştir. Hastaların ağız içi muayenesi yapılarak over jet, over bite vemalokluzyon sınıflamaları yapılmıştır. Sefalometrik radyograflar kullanılarak yapılan açısal ve doğrusal ölçümler ise aynı araştırmacı tarafından bir ay ara ile iki kere ölçülmüş ve tanımlayıcı istatistikler yapılarak her bir parameter için ortalama ve standart sapma hesaplanmıştır. Çalışmanın sonucuna göre, mevcut limitasyonlar dahilinde, çalışmaya dahil olan bruksizmli hastaların Angle Sınıf I maloklüzyon gösterdiği, sagital ve vertical anomalileri ifade eden açısal ölçümlerin normal değer aralığında olduğu fakat alt yüz yüksekliği dışındaki diğer doğrusal ölçümlerin normal sınırların altında kaldığı tespit edilmiştir.
Photopolymerized 3D Printing Scaffolds with Pt(IV) Prodrug Initiator for Postsurgical Tumor Treatment
Authors: Zhang Qingfei , Wang Xiaocheng , Kuang Gaizhen , Yu Yunru , Zhao Yuanjin
Published: August 2022

Biomedical scaffolds have shown great success in postsurgical tumor treatment; their current efforts are focusing on eradicating residual tumor cells and circulating tumor cells and simultaneously repairing postoperative tissue defects. Herein, we report a novel photopolymerized 3D scaffold with Pt(IV) prodrug initiator to achieve the desired features for tumor comprehensive therapy. The Pt-GelMA scaffold was fabricated from the microfluidic 3D printing of methacrylate gelatin (GelMA) bioinks through a Pt(IV)-induced photocrosslinked process without any other additional photoinitiator and chemotherapeutic drug. Thus, the resultant scaffold displayed efficient cell killing ability against breast cancer cells in vitro and significantly inhibited the local tumor growth and distant metastases on an orthotopic postoperative breast cancer model in vivo. Besides, benefiting from their ordered porous structures and favorable biocompatibility, the scaffolds supported the cell attachment, spreading, and proliferation of normal cells in vitro; could facilitate the nutrient transportation; and induced new tissue ingrowth for repairing tissue defects caused by surgery. These properties indicate that such 3D printing scaffold is a promising candidate for efficient postoperative tumor treatment in the practical application.
Metallic Aluminum Suboxides with Ultrahigh Electrical Conductivity at High Pressure
Authors: Huang Tianheng , Liu Cong , Wang Junjie , Pan Shuning , Han Yu , Pickard Chris J. , Helled Ravit , Wang Hui-Tian , Xing Dingyu , Sun Jian
Published: August 2022

Aluminum, as the most abundant metallic elemental content in the Earth’s crust, usually exists in the form of alumina (Al
2
O
3
). However, the oxidation state of aluminum and the crystal structures of aluminum oxides in the pressure range of planetary interiors are not well established. Here, we predicted two aluminum suboxides (Al
2
O, AlO) and two superoxides (Al
4
O
7
, AlO
3
) with uncommon stoichiometries at high pressures using first-principle calculations and crystal structure prediction methods. We find that the
P4/nmm
Al
2
O becomes stable above ~765 GPa and may survive in the deep mantles or cores of giant planets such as Neptune. Interestingly, the Al
2
O and AlO are metallic and have electride features, in which some electrons are localized in the interstitials between atoms. We find that Al
2
O has an electrical conductivity one order of magnitude higher than that of iron under the same pressure-temperature conditions, which may influence the total conductivity of giant planets. Our findings enrich the high-pressure phase diagram of aluminum oxides and improve our understanding of the interior structure of giant planets.
Continued Increases of Gross Primary Production in Urban Areas during 2000–2016
Authors: Cui Yaoping , Xiao Xiangming , Dong Jinwei , Zhang Yao , Qin Yuanwei , Doughty Russell B. , Wu Xiaocui , Liu Xiaoyan , Joiner Joanna , Moore Berrien
Published: August 2022

Urbanization affects vegetation within city administrative boundary and nearby rural areas. Gross primary production (GPP) of vegetation in global urban areas is one of important metrics for assessing the impacts of urbanization on terrestrial ecosystems. To date, very limited data and information on the spatial-temporal dynamics of GPP in the global urban areas are available. In this study, we reported the spatial distribution and temporal dynamics of annual GPP during 2000–2016 from 8,182 gridcells (0.5° by 0.5° latitude and longitude) that have various proportion of urban areas. Approximately 79.3% of these urban gridcells had increasing trends of annual GPP during 2000-2016. As urban area proportion (%) within individual urban gridcells increased, the means of annual GPP trends also increased. Our results suggested that for those urban gridcells, the negative effect of urban expansion (often measured by impervious surfaces) on GPP was to large degree compensated by increased vegetation within the gridcells, mostly driven by urban management and local climate and environment. Our findings on the continued increases of annual GPP in most of urban gridcells shed new insight on the importance of urban areas on terrestrial carbon cycle and the potential of urban management and local climate and environment on improving vegetation in urban areas.
LITERARY FEATURES OF THE COMIC GENRE IN ARKADY AVERCHENKO’S WORKS DURING HIS EMIGRATION TO EUROPE
Authors: HOLOBORODKO Yurii
Published: August 2022

The article analyzes some aspects of life and features of the work of the worldfamous satirist writer of the beginning of the last century Arkady Averchenko at the last stage of his emigration – during his staying in Europe, in particular, in the Czech Republic. The themes and motives of the writer’s works of this period of emigration, the characteristics of the characters, the main means of creating comic, changing the ideological direction and content of his writing in accordance with changes in worldview and understanding of events in the world such as the socio-political situation in the Bolshevik Russia and drastic changes in the lives of emigrants, who were forced to start a new, rather difficult, life, arriving in Europe after the October coup of 1917. The genre peculiarities of the European period of Arkady Averchenko’s work of 1922 – 1925 are determined. Despite the general satirical orientation of the writer, his previous humorous aesthetics remains relevant in the creative work of the writer. Thus, the collection «Children» published in 1922 is marked by sensitivity in the depiction of child psychology. However, the leading style remains tragicomic, which best realizes the motive of troubles of emigrants abroad. It takes place in a general atmosphere of nostalgia and longing for the lost homeland, a reappraisal of values caused by social upheavals, and an understanding of Russia’s destruction. The article considers the scientific reception of worldview changes in the emigration period of A. Averchenko in the studies of foreign and native scholars, as well as the phenomena of his work as the main dominants of the continuation of literary and artistic traditions. The creative phenomenon of Averchenko’s prediction of the future was noted, in particular, predicting the foreign policy strategy of the Soviet state, which was set out to consist of the capture of other countries or uncivilized interference in their lives.
Comparative Evaluation of Lipofectamine and Dendrimer for Transfection of Short RNA Into Human T47D and MCF-10A Cell Lines
Authors: Jahanafrooz Zohreh , Bakhshandeh Behnaz , Shirzadi Erfan
Published: August 2022

Purpose: Non-viral transfection approaches are extensively used in cancer therapy. The future of cancer therapy lies on targeted and efficient drug/gene delivery. The aim of this study was to determine the transfection yields of two commercially available transfection reagents (i.e. Lipofectamine 2000, as a cationic lipid and PAMAM G5, as a cationic dendrimer) in two breast cell lines: cancerous cells (T47D) and non-cancerous ones (MCF-10A). Methods: We investigated the efficiencies of Lipofectamine 2000 and PAMAM G5 for transfection/delivery of a labeled short RNA into T47D and MCF-10A. In addition to microscopic assessments, the cellular uptakes of the complexes (fluorescein tagged-scrambled RNA with Lipofectamine or PAMAM dendrimer) were quantified by flow cytometry. Furthermore, the safety of the mentioned reagents was assessed by measuring cell necrosis through the cellular PI uptake. Results: Our results showed significantly better efficiencies of Lipofectamine compared to PAMAM dendrimer for short RNA transfection in both cell types. On the other hand, MCF-10A resisted more than T47D to the toxicity of higher concentrations of the transfection reagents. Conclusion: Altogether, our research demonstrated a route for comprehensive epigenetic modification of cancer cells and depicted an approach to efficient drug delivery, which eventually improves both short RNA-based biopharmaceutical industry and non-viral strategies in epigenetic therapy.
MicroRNAs and Periodontal Disease: Helpful Therapeutic Targets?
Authors: Palideh Abdolhakim , Vaghari-Tabari Mostafa , Nosrati Andevari Ali , Qujeq Durdi , Asemi Zatollah , Alemi Forough , Rouhani Otaghsara Hemmatollah , Rafieyan Sona , Yousefi Bahman
Published: August 2022

Periodontal disease is the most common oral disease. This disease can be considered as an inflammatory disease. The immune response to bacteria accumulated in the gum line plays a key role in the pathogenesis of periodontal disease. In addition to immune cells, periodontal ligament cells and gingival epithelial cells are also involved in the pathogenesis of this disease. miRNAs which are small RNA molecules with around 22 nucleotides have a considerable relationship with the immune system affecting a wide range of immunological events. These small molecules are also in relation with periodontium tissues especially periodontal ligament cells. Extensive studies have been performed in recent years on the role of miRNAs in the pathogenesis of periodontal disease. In this review paper, we have reviewed the results of these studies and discussed the role of miRNAs in the immunopathogenesis of periodontal disease comprehensively. miRNAs play an important role in the pathogenesis of periodontal disease and maybe helpful therapeutic targets for the treatment of periodontal disease.
The Long Journey of Extracellular Vesicles towards Global Scientific Acclamation
Authors: Pirisinu Marco
Published: August 2022

Extracellular vesicles (EVs) are a heterogeneous class of cell-derived vesicles that are responsible for eliciting a wide array of biological processes. After decades of intense investigation, the therapeutic potential of EVs will be finally explored in a series of upcoming clinical trials. EVs are rapidly changing the understanding of human physiology and will undoubtedly transform the field of medicine. The applicability of EVs as diagnostic biomarkers and treatment vectors has captured the attention of the scientific community and investors, facilitating the rapid progression of numerous EVs-based platforms. This mini-review provides an outline of the pioneering discoveries, and their respective significances, on progressing EVs toward clinical use. We focus the attention of the readers on several promising classes of EVs that hold major opportunities to translate in clinical practice. Market analysis and future challenges facing EVs-based therapies are also discussed.
Combined Treatment of Dendrosomal-Curcumin and Daunorubicin Synergistically Inhibit Cell Proliferation, Migration and Induce Apoptosis in A549 Lung Cancer Cells
Authors: Eslami Seyed Sadegh , Jafari Davod , Ghotaslou Abbas , Amoupour Moein , Asri Kojabad Amir , Jafari Rasool , Mousazadeh Navid , Tarighi Parastoo , Sadeghizadeh Majid
Published: August 2022

Purpose: Chemotherapy drugs used to treat lung cancer are associated with drug resistance and severe side effects. There have been rising demands for new therapeutic candidates and novel approaches, including combination therapy. Here, we aimed to investigate the combinatorial effect of a dendrosomal formulation of curcumin (DNC) and daunorubicin (DNR) on the A549 lung cancer cell line. Methods: We performed cytotoxicity, apoptosis, cell migration, colony-formation capacity, and gene expression analysis to interpret the mechanism of action for a combination of DNC and DNR on A549 cells. Results: Our results revealed that the combination of DNC and DNR could synergistically inhibit the A549 cells’ growth. This synergistic cytotoxicity was further approved by flow cytometry, migration assessment, colony-forming capacity and gene expression analysis. DNR combination with DNC resulted in increased apoptosis to necrosis ratio compared to DNR alone. In addition, the migration and colony-forming capacity were at the minimal range when DNC was combined with DNR. Combined treatment decreased the expression level of MDR-1, hTERT and Bcl-2 genes significantly. In addition, the ratio of Bax/Bcl2 gene expression significantly increased. Our analysis by free curcumin, dendrosomes and DNC also showed that dendrosomes do not have any significant cytotoxic effect on the A549 cells, suggesting that this carrier has a high potential for enhancing the curcumin’s biological effects. Conclusion: Our observations suggest that the DNC formulation of curcumin synergistically enhances the antineoplastic effect of DNR on the A549 cell line through the modulation of apoptosis/necrosis ratio, as well as Bax/Bcl2 ratio, MDR-1 and hTERT gene expression.
Effects of Turmeric Concentrate on Cardiovascular Risk Factors and Exercise-Induced Oxidative Stress in Healthy Volunteers; an Exploratory Study
Authors: Hajleh Maha Noordin Abu , Al-Dujaili Emad Abdol Sahib
Published: August 2022

Purpose: Evidence suggests that turmeric intake can improve antioxidant defense, blood pressure (BP), ageing and gut microbiota. The effects of turmeric concentrate (curcumin) intake on cardiovascular risk factors and exercise induced oxidative stress were investigated. Methods: A randomized placebo-controlled study was performed to assess the effects of turmeric extract in healthy volunteers before and after a 30 min exercise bout. Participants (n=22) were given either turmeric concentrate or placebo supplements. Anthropometry, BP, pulse wave velocity (PWV), biomarkers of oxidative stress, perceived exertion and lipid peroxidation were assessed. Results: In the turmeric group, the expected BP response to exercise following turmeric was blunted and the increase was not significant compared to basal values followed by a decrease in final BP and PWV values. There were no significant differences in all baseline parameters between the placebo and the curcumin groups (P>0.05). A significant increase was observed in urinary antioxidant power (P=0.031) and total polyphenol levels (P=0.022) post turmeric intervention. The distance ran by the participants taking turmeric was significantly longer (P=0.005) compared to basal value. Those who took the placebo did not show significant changes. Conclusion: Our study suggests that turmeric concentrate intake can reduce BP and improve antioxidant, anti-inflammatory status and arterial compliance. Turmeric may improve exercise performance and ameliorates oxidative stress. Larger studies are warranted to validate these findings and test more cardiovascular risk factors.
CD44 Suppression Improved the Chemosensitivity of HT-29 Colorectal Cancer Cells to 5-Fluorouracil and Inhibited Cell Migration
Authors: Najafi Souzan , Rahimi Zohreh , Mansoori Behzad , Mohammadi Ali , Mohammadnejad Fatemeh , Amini Mohammad , Mokhtazadeh Ahad , Asadzadeh Zahra , Chi-Shing Cho William , Baradaran Behzad
Published: August 2022

Purpose: CD44 plays a pivotal role through tumorigenesis by regulating cancer cell metastasis, stemness, and chemosensitivity and is considered a promising therapeutic target for human cancers, including colorectal cancer (CRC). Therefore, the present research aimed to examine the simultaneous therapeutic effect of CD44 silencing and 5-fluorouracil (5-FU) on in vitro tumorigenesis of CRC cells. Methods: CD44 expression was initially evaluated in TCGA datasets and CRC tissues. Furthermore, functional analysis was performed on HT-29 CRC cells overexpressing CD44. The cells were transfected with CD44 siRNA and then treated with 5-FU. Consequently, to explore the combination therapy effect on cell viability, migration, apoptosis, and chromatin fragmentation, we performed MTT assay, scratch assay, Annexin V/PI staining and DAPI staining assays, respectively. The spheroid and colony formation assays were further employed to investigate stemness features. The gene expression at protein and mRNA levels were explored using western blotting and qPCR. Results: Our findings illustrated that CD44 was significantly overexpressed in CRC tissues compared to normal samples. The suppression of CD44 considerably promoted the chemosensitivity of HT-29 cells to 5-FU by apoptosis induction. Also, the combination therapy led to overexpression of apoptotic genes, including P53, caspase-3, and caspase-9, as well as downregulation of AKT1 expression. Furthermore, CD44 suppression, separately or combined with 5-FU, hindered stemness properties in HT-29 cells via downregulation of Sox2 and Nanog expression. Besides, the combination therapy remarkably downregulated MMPs and suppressed CRC cell migration. Conclusion: Considering its involvement in chemosensitivity to 5-FU, CD44 could be suggested as a potential target for improving the efficiency of CRC chemotherapy.
Cooperative Treatment of Gastric Cancer Using B7-H7 siRNA and Docetaxel; How Could They Modify Their Effectiveness?
Authors: Bolandi Nadia , Khadem Ansari Mohammad Hassan , Rasmi Yousef , Baradaran Behzad
Published: August 2022

Purpose: Despite the high prevalence of gastric cancer (GC), drug resistance is a major problem for effective chemotherapy. B7-H7 is a novel member of the B7 superfamily and is expressed in most common cancers. However, the role of B7-H7 on the aggressiveness of GC and chemosensitivity has remained unknown. Therefore, this study was designed to assess the effect of B7-H7 suppression using small interference RNA (siRNA) in combination with docetaxel on GC cells. Methods: MTT test was applied to determine the IC50 of docetaxel and the combined effect of B7-H7 siRNA and docetaxel on the viability of the MKN-45 cells. To determine B7-H7, BCL-2, BAX, and caspase-3-8-9 genes expression, qRT-PCR was performed. Furthermore, flow cytometry was applied to evaluate apoptosis and the cell cycle status. Finally, to evaluate the effect of this combination therapy on migratory capacity and colony-forming ability, wound healing assay and colony formation test were employed, respectively. Results: B7-H7 suppression increased the chemo-sensitivity of MKN-45 cells to docetaxel. The expression of B7-H7 mRNA was reduced after using B7-H7 siRNA and docetaxel in MKN-45 GC cells. Also, B7-H7 suppression alongside docetaxel reduced cell migration and colony formation rate, arrested the cell cycle at the G2-M phase, and induced apoptosis by modulating the expression of apoptotic target genes. Conclusion: B7-H7 plays a significant role in the chemo-sensitivity and pathogenesis of GC. Therefore, B7-H7 suppression, in combination with docetaxel, may be a promising therapeutic approach in treating GC.
Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
Authors: Shaseb Elnaz , Ghaffary Saba , Garjani Alireza , Zoghi Elnaz , Maleki Dizaji Nasrin , Soltani Somaieh , Sarbakhsh Parvin , Somi Mohammad Hossein , Valizadeh Parya , Taghizadieh Ali , Faghihdinevari Masood , Varshochi Mojtaba , Naghily Behrooz , Bayatmakoo Zhinous , Saleh Parviz , Taghizadeh Sepehr , Haghdoost Mehdi , Owaysi Hamid , Ravanbakhsh Ghavghani Fatemeh , Tarzamni Mohammad Kazem , Moradi Rojin , Javan Ali Azar Fateme , Shabestari Khiabani Saeid , Ghazanchaei Ardavan , Hamedani Sana , Hatefi Shahabeddin
Published: August 2022

Purpose: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. Methods: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. Results: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (P=0.014) and 4.9% vs. 23.9% (P≤0.001), respectively). Admission time characteristics were the same for both groups except for diabetes and hyperlipidemia, which were significantly different between the two groups. Observations of naproxen consumption on endpoints, duration of hospitalization, and the levels of spO2 did not show any significant differences between the intervention and the control group. The adjusted OR for intubation in the intervention group versus the control group was 0.21 [95% CI, 0.04-0.99 (P=0.047)]. Conclusion: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.
The Northern kʻustak administrative units of the Sasanian Iran in 6th century CE
Authors: KHACHATRYAN Henrik
Published: August 2022

In the 6th century CE, the Sasanian empire was divided into four administrative units already during the second reign of Kavad I, however, it was during the time of Khosrov Anushirvan that these regions were transformed into the military-administrative units – kʻustaks, where the administrative power belonged to the padgospan and the military to the spahbed. The northern kʻustak or kʻust-i-Kapkoh was included the marzpanates: Armenia (divided into the three military-administrative units – Tanutirakan gund, Vaspurakan gund, Syunikʻ), Georgia, Albania and the šahrs: Adharbādhakān, Gīlān, Dlmunkʻ, Zanjān, Ghazvīn, Ṭabaristān and Ray. This paper reviews the administrative of the northern kʻustak based on the Classical Armenian, Arabic and Persian primary sources.
A Phytochemical Characterization and Screening Test of Simplisia and Sabrang Garlic (Eleutherine bulbosa (Mill.) Urb.) Tuber Extract
Authors: Yanti Fitri , Heni Kurniasari  , Josep N. Hutahaean
Published: August 2022

Sabrang onion (Eleutherine bulbosa (Mill.) Urb.) has been used for generations for various diseases such as breast and colon cancer, hypertension, diabetes mellitus, hypercholesterolemia and stroke. This study aims to determine the characterization and phytochemical screening of simplicia and sabrang onion bulb extract. Extracts were made by graded maceration using solvents based on their polarity levels, n-hexane, ethylacetate and ethanol as well as phytochemical screening and characterization of simplicia and extracts. The results of simplicia characterization, sabrang onion n-hexane extract (ENBS), sabrang onion ethylacetate extract (EEABS) and sabrang onion ethanol extract (EEBS) obtained water content of 8.64%, respectively; 4.98%; 8.27% and 9.11%; water soluble extract content of 8.52%; 1.12%; 9.51% and 72.19%; ethanol soluble extract content of 14.05%; 2.28%; 49.26% and 81.66%; total ash content 2.89%; 0.34%; 0.43% and 1.73% and the acid insoluble ash content is 0.59%; 0.06%; 0.07% and 0.20%. The results of the phytochemical screening of simplicia and extracts obtained groups of alkaloids, flavonoids, glycosides, saponins, anthraquinone glycosides, tannins and triterpenoids/steroids.
Midwife Care In Ny.R Family Planning With Implant Method In Mandiri Midwife Practice Sri Kurniawati
Authors: Wati Tri Suci Dewi , Indah Wahyuni
Published: August 2022

Efforts are being made to control the population and direct the mobility of the population to create a society that grows in balance with the family planning program (KB). A quality and prosperous small family can be planned by every family through the family planning program. Providing family planning midwifery care to Mrs. Implant acceptor using Varney's 7-step obstetric management. The case study used a descriptive method with the scope of patients being Kb implant acceptors, when it was carried out on June 3, 2021 to June 7, 2021 at PMB Sri Kurniawati according to midwifery science. On June 3, 2021 to June 7, 2021 Mrs. R has become an implant KB acceptor, the implant is installed well and the mother has received therapy. Family planning care is done by providing counseling to mothers about the contraceptives used so that Mrs. Rahayu decided to become a new acceptor of KB implants by signing the infoconsent that had been given to the mother for implant placement. After post-implant installation, the mother received KIE regarding post-implant family planning treatment.
Meningkatkan Pengetahuan Masyarakat Mengenai Pencegahan Hipertensi di RT 01, Desa Pojoksari, Kecamatan Rowosari, Kabupaten Kendal Tahun 2022
Authors: Widi hastuti Siti Kurnia , Afita Shafira Cahya , Rosyidah Rosyidah
Published: August 2022

Hipertensi merupakan salah satu masalah kesehatan terbesar di dunia. Hipertensi dapat muncul tanpa tanda dan gejala, sehingga penderita hipertensi tidak menyadari bahwa dirinya mengalami hipertensi dan tidak melakukan pengobatan. Salah satu hal yang dapat dilakukan agar seseorang mengetahui dirinya mengidap hipertensi atau tidak adalah dengan mengenali penyakit hipertensi terlebih dahulu. Berdasarkan diagnosis komunitas yang pernah dilakukan, hipertensi merupakan salah satu prioritas masalah yang harus diselesaikan di RT 01 RW 04 Desa Pojoksari, Kecamatan Rowosari, Kabupaten Kendal. Penyuluhan kesehatan dilakukan bertujuan untuk meningkatkan pemahaman masyarakat tentang pencegahan hipertensi, khususnya kepada orang dewasa sebagai sasaran yang rentan hipertensi. Penyuluhan kesehatan dilakukan dengan sasaran 20 peserta yang dilaksanakan di rumah warga di RT 01 Desa Pojok Sari, pada Tanggal 22 dan 24 Juni 2022 dari pukul 14.00 WIB hingga selesai. Kegiatan penyuluhan terdiri dari pretest, penyampaian materi, penyampaian leaflet dan Poster, sesi tanya jawab, dan posttest. Hasil kegiatan didapatkan hasil yaitu adanya peningkatan pengetahuan masyarakat yang diketahui melalui hasil pretest dan posttest. Hasil tersebut menunjukkan adanya peningkatan nilai rata-rata dan nilai minimum posttest dibandingkan  pretest, yaitu: nilai rata-rata pretest 68 dan posttest 91. Peningkatan juga terjadi pada nilai minimum pretest dan posttest, yaitu: nilai 40 menjadi 60
IMPLEMENTASI KEBIJAKAN BUMDES DALAM MENINGKATKAN PEREKONOMIAN MASYARAKAT MELALUI PENGELOLAAN SAMPAH DI DESA BANGUNREJO KABUPATEN KENDAL
Authors: Rizzal Firmanudin  , Maulida Putri Rahmawati  , Suprihatma
Published: August 2022

This research was conducted in Bangunrejo Village, Patebon District, Kendal Regency. This study aims to determine how the implementation of Village Owned Enterprises (BUMDes) policies in Bangunrejo Village, Kendal Regency. in the process of a good waste management unit and have carried out the correct procedures so that in the future they can turn the waste management unit into waste processing to improve the economy of the people of Bangunrejo Village. Therefore, research related to policy implementation at BUMDes Bangun Karya was carried out. This study uses Mariiee S. Grindle's theory of policy implementation, namely implementation which is influenced by two variables, namely the policy content variable (content) and the policy environment (context). The data collection techniques are observation and interviews which are then processed and analyzed qualitatively. In collecting interview data, it was carried out in Bangunrejo Village, Kendal Regency. The results of this study are: (1) the driving and inhibiting factors for the implementation of the BUMDes policy of the waste management unit are still constrained by the limited tools needed for good waste management in order to improve the community's economy (2) The role of the community is very important in the success of the BUMDes waste management unit so that can improve the economy of the community and village
IMPLEMENTASI E-GOVERNMENT DALAM PEMERINTAHAN KECAMATAN SEDAYU “SEDAYU SMART DISTRIC”
Authors: Ardiyati
Published: August 2022

The research have a purpose to analyze the implementation of e-government policies in Sedayu District government in the concept of "Sedayu Smart District". The study used a qualitative descriptive method by intering various government stakeholders in Sedayu District and the Communication and Information Agency of Bantul Regency. The research was also carried out by searching primary documents in the form of Sedayu sub-district government documents, and secondary documents in the form of news in various media. The study found that the implementation of Sedayu Smart District in the concept of "Jagoriko" was poorly planned, lacked coordination, lacked monitoring and evaluation. Implementation of policies is less institutionalized and dependent on the leadership so that it is less sustainable. The lack of policy implementation has led to the grand design of Bantul Smart City which refers to the 6 pillars of the target of e-government development in local government. Improvements need to be made in planning, coordinating, implementing, monitoring and evaluating Sedayu Smart District policies in order to remain sustainable. The concept of e-government in the administration of sub-district government in Bantul Regency is an innovation of each regional government organization
Deflection of Formula One Race Car Rear Wing using Numerical Simulations
Authors:   Department of Aerospace Engineering, Hindustan Institute of Technology and Science, Chennai (Tamil Nadu), India., Kumar V Sai Hemanth
Published: August 2022

Formula One is a track-based aerodynamic race between teams. In the design of motorsport cars, aerodynamics is crucial. When compared to the other race cars on the grid, the race car with the best aerodynamic performance performs well on the track and has a good lap time. The design of rear wing has significant influence on the performance of a race car as much of the downforce is provided by rear wing. Using structural and computational models, this paper tries to link the static and dynamic performance of a Formula 1 race car rear wing due to its deflection. Solidworks is used to design a rear wing model of an F-1 car, which is then transferred to Ansys. A speed of 300 kmph is considerd for the study as speed of F-1 cars range from 280 – 340 kmph on Straights. To determine the aerodynamic loadings on the model at 300 kmph, a fluid simulation is run in fluent. Turbulence model of Transition K- Kl- Omega was used. To determine deflection owing to the aerodynamic loads calculated, a structural analysis is performed in Ansys Static Structural. From structural analysis it is evident that deflection exists. Further computational simulations of deflected models about its center of gravity are performed to compare the effects of aeroelasticity of a race car’s rear wing. It is evident from the simulations that a 2 deflection in the wing resulted in a 3 % decrease in drag and a 4 % decrease in downforce which gives a higher performance gain in case of high-speed race cars.
Deep Learning Approach for Unmanned Aerial Vehicle Landing
Authors:   Research Scholar, Artificial Intelligence &  Robotics, College of Engineering, Pune (Maharashtra), India., Moholkar Utkarsh R , Patil Dipti D ,   Associate Professor, Department of Information  Technology, MKSSS’s Cummins College of Engineering for Women, Pune (Maharashtra), India., Kumar Vinod ,   Director, U.R. Rao Satellite Centre, Indian Space  Research Organization, Bengaluru (Karnataka), India, Patil Archana ,   Assistant Professor, Department of Computer  Engineering & Information Technology, College of Engineering, Pune (Maharashtra), India.
Published: August 2022

It is one of the biggest challenges to land an unmanned aerial vehicle (UAV). Landing it by making its own decisions is almost impossible even if progress has been made in developing deep learning algorithms, which are doing a great job in the Artificial Intelligence sector. But these algorithms require a large amount of data to get optimum results. For a Type-I civilization collecting data while landing UAV on another planet is not feasible. But there is one hack all the required data can be collected by creating a simulation that is cost-effective, time-saving, and safe too. This is a small step toward making an Intelligent UAV that can make its own decisions while landing on a surface other than Earth's surface. Therefore, the simulation has been created inside gaming engine from which the required training data can be collected. And by using that training data, deep neural networks are trained. Also deployed those trained models into the simulation and checked their performance
Disrupted access and success: Students’ transition to university in the time of Covid-19
Authors: Inglis Helen , Combrinck Celeste , Simpson Zach
Published: August 2022

The transition to university is complex and plays an essential role in determining students’ success in higher education. In South Africa and other global South contexts, students come from diverse backgrounds, and many have to cross what Boaventura de Sousa Santos calls an 'abyssal line'. Students in university in 2020 experienced an abrupt additional transition: to online learning, as universities responded to the Covid-19 pandemic. The current study investigates second-year engineering students' perceptions of the impact of the lockdown on their own studies, and their impressions of how first-year students might have felt this impact, through semi-structured, in-depth interviews. We sought to uncover the particular discourses that students draw on when describing what it was like to experience engineering study within a global pandemic. Throughout the student narratives, we identify a multiplicity of discourses around their identity as university students: as formed through connections with peers, lecturers, the university and the physical campus; as challenged by conflicting demands when studying at home; positioned as able to manage time and work; and vulnerable to threat from failure and the immutable force of online learning. We conclude with implications for universities and student success beyond the pandemic.
From micro to macro levels of practice: A showcase of a SoTL journey within and beyond classroom experiences
Authors: Mohd-Yusof Khairiyah , Samah Narina
Published: August 2022

Scholarship of Teaching and Learning (SoTL) is closely related to a teacher's journey of personal and professional growth, which initially occurs in the classroom. In higher education, where academics are recognised experts in their fields, SoTL activities are critical for translating educational principles into innovative practices that are consistent with the body of knowledge, thus significantly facilitating the learning process of students. When implemented consistently, two components of SoTL - reflective practice and practice dissemination - have the potential to accelerate growth not only at the micro (classroom) level, but also at the meso (institutional) and macro (national and international) levels. This article showcases a SoTL journey that began with a micro level practice in engineering classes and progressed into meso and macro level implementations. Beginning with student-centred learning approaches designed to assist students with classroom engagement, motivation enhancement and contextualised learning during a challenging course, the practice expanded into institutional-level experience-sharing sessions. This resulted in the development of structured training programmes and later, a centre of excellence. SoTL practice at the institutional level paved the way for national and international professional development training. This reflection showcases SoTL implementation at all three levels while demonstrating the potential for growth from one level to another leading to wide-ranging impacts both within and beyond the classroom.
No student left behind: ‘Pedagogies of comfort’ or ‘pedagogies of disruption’?
Authors: Samuel Michael
Published: August 2022

This article explores the lessons learnt from the short-term emergency remote teaching and learning (ERTL) approach adopted to tackle the continuation of the higher education (HE) academic programme during the COVID-19 pandemic. It first examines the primary goals of the official South African “No student left behind” (NSLB) campaign, which emphasises the agenda to address a social justice concern about students’ participation and access to HE. It reflects on recent research studies around this matter which tended to foreground technical and operational considerations. Instead, this article presents an alternate lens for shifting the discourse of HE, especially postgraduate studies, to activate deep, critical and autonomous engagement in teaching and learning. The theoretical model presented highlights staff and students working outside pedagogies of comfort and expanding into spaces of disrupting previous habituated pedagogies. The article draws on the reflective experiences of facilitating postgraduate education programmes: two PhD cohort programmes in Mauritius and South Africa (involving students who were schoolteachers and HE lecturers) and a Postgraduate Diploma in Higher Education Studies (involving students from rural university settings in South Africa). The data reveals that despite intentions to drive an alternative mode of critical, disruptive online modalities in curriculum delivery, students subtly pushed back towards working within the comfort zones of their previous conceptions of front-led, teacher-driven pedagogies. A disruptive pedagogy was not fully activated as students professed preferences to revert to the old routine agendas in pre-COVID times. This article argues that this constitutes a missed opportunity to learn from the ERTL era to inform alternative, more robust, critical pedagogies for the long term. The responses suggest that the HE system will continue to bifurcate disparities between those more willing to look to the past and those embracing a learning opportunity for the future.