bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of prognostic immune-related lncRNA signature predicting the overall survival for colorectal cancer
Authors: Li Jianxin , Han Ting , Wang Xin , Wang Yinchun , Chen Xuan , Chen Wangsheng , Yang Qingqiang
Published: January 2023

Long non-coding RNA (lncRNA) is an important regulator of gene expression and serves a fundamental role in immune regulation. The present study aimed to develop a novel immune-related lncRNA signature to assess the prognosis of patients with colorectal cancer (CRC). Transcriptome data and clinical information of patients with CRC were downloaded from The Cancer Genome Atlas (TCGA) and UCSC Xena platforms. Immune-related mRNAs were extracted from the Molecular Signatures Database (MSigDB), and the immune-related lncRNAs were identified based on correlation analysis. Then, univariate, Lasso and multivariate Cox regression were applied to construct an immune-related lncRNA signature, and CRC patients were divided into high- and low-risk groups according to the median risk score. Finally, we evaluated the signature from the perspectives of clinical outcome, clinicopathological parameters, tumor-infiltrating immune cells (TIICs), immune status, tumor mutation burden (TMB) and immunotherapy responsiveness. In total, 272 immune-related lncRNAs were identified, five of which were applied to construct an immune-related lncRNA signature. The signature divided patients with CRC into low- and high-risk groups, the prognosis of patients in the high-risk group were significantly poorer than those in low-risk group, and the results were further confirmed in external validation cohort. Furthermore, the high-risk group showed aggressive clinicopathological characteristics, specific TIIC and immune function status, and low sensitivity to immunotherapy. The immune-related lncRNA signature could be exploited as a promising biomarker for predicting the prognosis and immune status of patients with CRC.
Pharmaceutical toxicity is a common pattern of inpatient acute poisonings in Birjand City, East of Iran
Authors: Naseri Kobra , Kiani Zahra , Sajadi Zakieh Sadat , Mehrpour Omid , Javadmoosavi Seyed Yoosef , Forouzanfar Fatemeh , Sadeghi Mahmood
Published: January 2023

Information on the pattern of acute poisonings in hospitals of Birjand city, Iran, is limited. This study aimed to address this knowledge gap by examining the admissions in a major poisoning center in eastern Iran. This cross-sectional study included patients admitted to the Imam Reza Hospital in Birjand over 12 months. Medical records of the poisoned patients were reviewed, and the study variables were used for data analysis. During the study period, 534 cases of acute poisonings were evaluated. The patient's ages ranged from 12 to 84 years, with a high rate of poisonings between 15 and 35 years. The female predominance in poisoning cases was 52.1%. Most cases of poisonings occurred in spring, and the common route of exposure was oral (93.1%). The incidence of poisoning in married couples, uneducated patients, and residents of urban areas was 56.5%, 90.1%, and 74.6%, respectively. Patients with a previous medical history experienced addiction and psychiatric disorders. Intentional poisoning accounted for 23.4% of acute poisoning cases referred to the hospital in the current study. The main groups of toxicants were pharmaceutical products (48.1%), narcotics (25.8%), chemical products (10.1%), envenomation (7.1%), and alcohol (1.7%). The mean hospital stay was 2.5 ± 3.0 days, and the final treatment outcome was complete recovery, except for one patient intoxicated by warfarin and alprazolam. Our results indicate that the high toxicity cases were related to pharmaceutical product and opioids abuse, especially methadone (8.4%), alprazolam (7.9%), clonazepam (7.5%), and acetaminophen (9.9%) taken orally and more commonly happened at home. Due to the high rate of deliberate poisonings, especially among young adults and students, monitoring drug distribution and exceptional attention to mental health should be seriously considered by national health authorities to prevent suicide attempts.
Expression and significance of IL-6 and IL-8 in canine mammary gland tumors
Authors: Ren Xiaoli , Fan Yuying , Shi Dongmei , Liu Yun
Published: January 2023

Mammary gland tumors are the most common malignant diseases which seriously threaten the health of women and female dogs. There is a lack of an effective tumor marker which can effectively assist in the early diagnosis, and prognosis of mammary gland tumors in veterinary clinical medicine. IL-6, and IL-8 as immunosuppressive factors may stimulate tumor cells growth, contribute to loco-regional relapse and metastasis that might be utilized as a marker for immunity status and monitoring of the course of tumor. The present study aimed to investigate the expression of serum/tissue IL-6, IL-8 and IL-10 in canine mammary gland tumors using Enzyme linked immunosorbent assay(ELISA), Western blot and Immunohistochemistry assay(IHC) to determine whether it is associated with tumor progression. The results showed that levels of IL-6, IL-8 and IL-10 in serum were higher in malignant tumor group than that in benign tumor and control group; the expression levels of IL-6 and IL-8 were significantly elevated in grade III than in grade I and II and was related to metastasis. Likewise, IL-6 and IL-8 were also highly expressed in malignant tumor tissues. Elevated expression of IL-6 was associated with histopathological grade and metastases in malignant tumors. Moreover, high expression of IL-6 occurred in the Basal-like subtypes whereas high expression of IL-8 occurred in the Luminal B subtypes. The results of this study indicated that changes of IL-6 and IL-8 in the tumor microenvironments were closely related to the diseases status and may be used as a potential diagnostic or biomarker in canine mammary gland tumors.
Experimental validation of proton boron capture therapy for glioma cells
Authors: Shtam Tatiana , Burdakov Vladimir , Garina Alina , Garaeva Luiza , Tran Nhan Hau , Volnitskiy Andrey , Kuus Eva , Amerkanov Dmitry , Pack Fedor , Andreev Georgy , Lubinskiy Andrey , Shabalin Konstantin , Verlov Nicolay , Ivanov Evgeniy , Ezhov Victor , Lebedev Dmitry , Konevega Andrey L.
Published: January 2023

Proton boron capture therapy (PBCT) has emerged from particle acceleration research for enhancing the biological effectiveness of proton therapy. The mechanism responsible for the dose increase was supposed to be related to proton-boron fusion reactions (11B + p → 3α + 8.7 MeV). There has been some experimental evidence that the biological efficiency of protons is significantly higher for boron-11-containing prostate or breast cancer cells. The aim of this study was to evaluate the sensitizing potential of sodium borocaptate (BSH) under proton irradiation at the Bragg peak of cultured glioma cells. To address this problem, cells of two glioma lines were preincubated with 80 or 160 ppm boron-11, irradiated both at the middle of 200 MeV beam Spread-Out Bragg Peak (SOBP) and at the distal end of the 89.7 MeV beam SOBP and assessed for the viability, as well as their ability to form colonies. Our results clearly show that BSH provides for only a slight, if any, enhancement of the effect of proton radiation on the glioma cells in vitro. In addition, we repeated the experiments using the Du145 prostate cancer cell line, for which an increase in the biological efficiency of proton irradiation in the presence of sodium borocaptate was demonstrated previously. The data presented add new argument against the efficiency of proton boron capture therapy when based solely on direct dose-enhancement effect by the proton capture nuclear reaction, underlining the need to investigate the indirect effects of the secondary alpha irradiation depending on the state and treatment conditions of the irradiated tissue.
Ionomics-metabolome association analysis as a new approach to the impact of dietary copper levels in suckling piglets model
Authors: Zhang Feng , Yao Wen , Ji Xu , Liu Xiaodan , Jin Erhui
Published: January 2023

Ionomics-metabolomics association analysis is a novel method to elucidating the potential mechanisms underlying the effects of dietary copper on the overall health parameters of suckling piglets model. Few studies have elucidated the relationship between the changes of ionic and metabolic homeostasis responses to dietary copper level. The growth performance data was obtained from 180 suckling piglets which access to different copper levels: 6 (low copper diet, LC), 20 (control diet, CON), and 300 (high copper diet, HC) mg·kg−1 copper (based on diet, supplementation from CuSO4), and offered ad libitum from d 14 until weaning at 40 d of age. Dietary high level copper (300 mg·kg−1) increased the ADG and ADFI during d 14 to 28 of piglets. Six elements (Mg, Na, K, P, Cu, and Mn) concentrations significantly changes in hair among the three treatment diets. The significant increased concentrations of Na and K, and decreased concentration of Mg and Mn in 300 mg·kg−1 than 20 mg·kg−1 copper diet was observed. In current study, with the increase in copper level from 20 to 300 mg·kg−1 in diet, the correlation between hair Na, K and Cu, Mn, Zn vanish. Hair Na and K were positively correlated with serum total antioxidant capacity (T-AOC) and negatively correlated with tumor necrosis factor-α (TNF-α). The hair Cu was negatively correlated with serum malondialdehyde (MDA), total bile acid (TBA). The fecal Cu was positively correlated with serum growth hormone (GH). The results suggested that the average daily gain (ADG) in 6 mg·kg−1 copper diet and the average daily feed intake (ADFI) in 20 mg·kg−1 copper diet were decreased than 300 mg·kg−1 copper diet during d 14 to 28 and the ADG was decreased in 6 and 20 mg·kg−1 copper diets in d 29 to 40 of piglets. Dietary 20 mg·kg−1 copper maintain ion homeostasis due to increase the number of positive correlations between macroelements-microelements in hair and serum. Significantly changed Na, K, Mg, Mn and Cu concentrations in hair can reflect the adverse effects of dietary 300 mg·kg−1 copper of suckling piglets. We believe our results may benefit people to gain a better understanding of the ion interactions and metabolic homeostasis of heavy metal elements that are critical to human and animal health.
Analysis of docosahexaenoic acid hydroperoxide isomers in mackerel using liquid chromatography–mass spectrometry
Authors: Kusumoto Ibuki , Kato Shunji , Nakagawa Kiyotaka
Published: January 2023

Docosahexaenoic acid (DHA) is mostly esterified in food and is easily oxidized by exposure to heat or light. Hydroperoxide positions of DHA mono-hydroperoxide (DHA;OOH) provide information on oxidation mechanisms (e.g., radical- or singlet oxygen oxidation), yet direct identification of esterified DHA;OOH isomers has not been achieved. We previously accomplished the direct analysis of free DHA;OOH isomers with liquid chromatography-mass spectrometry (LC–MS/MS). In this study, we developed an LC–MS/MS method for direct analysis of esterified DHA;OOH based on our previous study. The developed method was capable of distinguishing esterified DHA;OOH isomers in raw- and oxidized mackerel. The result suggested that radical oxidation of esterified DHA can progress even in refrigeration. Different transitions were observed depending on the oxidation mechanism and lipid class. The analytical method and insights obtained in this study would be valuable to further understand and effectively prevent DHA oxidation in food products.
Seismic performance of steel-reinforced concrete-filled rectangular steel tubes after exposure to non-uniform fire
Authors: Han Yi , Bao Yan-Hong
Published: January 2023

In actual engineering, non-uniform fire boundary circumstances including single-sided fire, neighboring or related two-sided fire, and three-sided fire, are created due to the varying placements of the columns. In this paper, the seismic performance of SRCFST members subjected to non-uniform fire was investigated by the method of finite element simulation. First of all, the P-Δ curve, ductility coefficient, stiffness, and energy dissipation of the members following non-uniform fire were investigated. As the number of fire surfaces decreases, the maximum overfire temperature at the center of the section decreases, damage decreases, stiffness degradation decreases, and energy dissipation capacity increases. Next, the load distribution of each component in the SRCFST member was calculated using a three-sided fire as an example, the results show that steel tubes play the most dominant role in the seismic performance after fire, followed by steel sections and concrete the least. Last, a parametric study of the key variables influencing the ductility coefficient was carried out.
Computational fluid dynamics comparison of prevalent liquid absorbents for the separation of SO2 acidic pollutant inside a membrane contactor
Authors: Cao Yan , Taghvaie Nakhjiri Ali , Ghadiri Mahdi
Published: January 2023

In recent years, the emission of detrimental acidic pollutants to the atmosphere has raised the concerns of scientists. Sulphur dioxide (SO2) is a harmful greenhouse gas, which its abnormal release to the atmosphere may cause far-ranging environmental and health effects like acid rain and respiratory problems. Therefore, finding promising techniques to alleviate the emission of this greenhouse gas may be of great urgency towards environmental protection. This paper aims to evaluate the potential of three novel absorbents (seawater (H2O), dimethyl aniline (DMA) and sodium hydroxide (NaOH) to separate SO2 acidic pollutant from SO2/air gaseous stream inside the hollow fiber membrane contactor (HFMC). To reach this goal, a CFD-based simulation was developed to predict the results. Also, a mathematical model was applied to theoretically evaluate the transport equations in different compartments of contactor. Comparison of the results has implied seawater is the most efficient liquid absorbent for separating SO2. After seawater, NaOH and DMA are placed at the second and third rank (99.36% separation using seawater > 62% separation using NaOH > 55% separation using DMA). Additionally, the influence of operational parameters (i.e., gas and liquid flow rates) and also membrane/module parameters (i.e., length of membrane module, hollow fibers’ number and porosity) on the SO2 separation percentage is investigated as another highlight of this paper.
TeV/m catapult acceleration of electrons in graphene layers
Authors: Bonţoiu Cristian , Apsimon Öznur , Kukstas Egidijus , Rodin Volodymyr , Yadav Monika , Welsch Carsten , Resta-López Javier , Bonatto Alexandre , Xia Guoxing
Published: January 2023

Recent nanotechnology advances enable fabrication of layered structures with controllable inter-layer gap, giving the ultra-violet (UV) lasers access to solid-state plasmas which can be used as medium for electron acceleration. By using a linearly polarized 3 fs-long laser pulse of 100 nm wavelength and 10$$^{21}$$

21

W/cm$$^2$$

2

peak intensity, we show numerically that electron bunches can be accelerated along a stack of ionized graphene layers. Particle-In-Cell (PIC) simulations reveal a new self-injection mechanism based on edge plasma oscillations, whose amplitude depends on the distance between the graphene layers. Nanometre-size electron ribbons are electrostatically catapulted into buckets of longitudinal electric fields in less than 1 fs, as opposed to the slow electrostatic pull, common to laser wakefield acceleration (LWFA) schemes in gas-plasma. Acceleration then proceeds in the blowout regime at a gradient of 4.79 TeV/m yielding a 0.4 fs-long bunch with a total charge in excess of 2.5 pC and an average energy of 6.94 MeV, after travelling through a graphene target as short as 1.5 $$\upmu $$
μ
m. These parameters are unprecedented within the LWFA research area and, if confirmed experimentally, may have an impact on fundamental femtosecond research.
Associations between oral health status and risk of fractures in elder adults
Authors: Hong Seok Woo , Lee JunYeop , Kang Jeong-Hyun
Published: January 2023

Oral health condition, bone mineral density, skeletal muscle mass, fall, fracture, and frailty seem to be strongly interconnected. This study aimed to investigate associations between probability of osteoporotic fractures and oral health in the elderly. In total, 2322 Korean subjects from the 2008—2009 Korea National Health and Nutritional Examination Survey aged over 65 years were included. The 10-year probabilities of major and hip fractures were calculated using the Fracture Risk Assessment (FRAX) tool. Data on anthropometry, skeletal bone mineral density, sociodemographic characteristics, physical activity, individual history of fractures and falls, parental history of osteoporosis, number of teeth, metabolic syndrome, the Decayed, Missing, and Filled permanent Teeth index, and Community Periodontal Index (CPI), were collected. Participants were classified into three groups based on FRAX score for major osteoporotic fractures. A multivariate linear regression analysis was conducted to analyze associations between FRAX scores and oral health-related factors, adjusting for confounding factors. BMI, presence of metabolic syndrome, number of teeth, dental patterns, and CPI score showed significant differences among three groups in males and females. Results from multivariate linear regression analysis demonstrated significant relationships between total tooth number and probabilities of fracture in male and female elderly. The interdisciplinary approach for handling osteoporosis and sarcopenia including dentists, physicians is necessary to facilitate a better quality of life in the elderly.
Combined oceanic and atmospheric forcing of the 2013/14 marine heatwave in the northeast Pacific
Authors: Chen Huan-Huan , Wang Yuntao , Xiu Peng , Yu Yi , Ma Wentao , Chai Fei
Published: January 2023

An unprecedented warm sea surface temperature (SST) anomaly event, namely, the Blob, occurred in the northeast Pacific during the winter (October–January) of 2013/2014, causing substantial economic and ecological impacts. Here, we explore the driving forces of the Blob from both atmospheric and oceanic perspectives and show that the Blob primarily resulted from weak wintertime cooling due to the reduced air-sea heat flux transfer from the ocean to the atmosphere and the reduced horizontal advection of cold water in the upper ocean. Both mechanisms were attributed to an anomalous high-pressure system over the study region. Specifically, the anomalous air-sea heat flux, which was dominated by turbulent heat flux anomalies, was mainly induced by the increased air temperature (i.e., with a contribution of approximately 70%) and the weakened wind speed associated with the high-pressure system. The reduced horizontal heat advection was mainly due to the weakened winds acting on the ocean temperature meridional gradient. Using a regional ocean numerical model with different experimental runs, we evaluated the contributions of air temperature and wind drivers to the Blob at both the surface and subsurface of the ocean. The Blob was absent when the model was forced by climatology-air-temperature. Both the SST and integrated ocean heat content (OHC, 0–150 m) decreased, and the mixed layer depth (MLD) was deeper than that in the control run forced by real atmospheric conditions. In the climatology-winds experiment, obvious warm anomalies still existed, which were similar to but weaker than the control run. The SST (OHC) and MLD values in the climatology-winds run were between those of the climatology-air-temperature run and the control run. Compared to former studies that attribute the formation of the Blob to an anomalous air-sea heat flux and horizontal advection mainly induced by reduced winds, our study demonstrates that anomalous warm air temperatures played a more important role in its formation.
Making machine learning matter to clinicians: model actionability in medical decision-making
Authors: Ehrmann Daniel E. , Joshi Shalmali , Goodfellow Sebastian D. , Mazwi Mjaye L. , Eytan Danny
Published: January 2023

Machine learning (ML) has the potential to transform patient care and outcomes. However, there are important differences between measuring the performance of ML models in silico and usefulness at the point of care. One lens to use to evaluate models during early development is actionability, which is currently undervalued. We propose a metric for actionability intended to be used before the evaluation of calibration and ultimately decision curve analysis and calculation of net benefit. Our metric should be viewed as part of an overarching effort to increase the number of pragmatic tools that identify a model’s possible clinical impacts.
A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients
Authors: Peters Lauren A. , Friedman Joshua R. , Stojmirovic Aleksandar , Hagen Jacob , Houten Sander , Dodatko Tetyana , Amaro Mariana P. , Restrepo Paula , Chai Zhi , Rodrigo Mora J. , Raymond Holly A. , Curran Mark , Dobrin Radu , Das Anuk , Xiong Huabao , Schadt Eric E. , Argmann Carmen , Losic Bojan
Published: January 2023

Previous studies have conducted time course characterization of murine colitis models through transcriptional profiling of differential expression. We characterize the transcriptional landscape of acute and chronic models of dextran sodium sulfate (DSS) and adoptive transfer (AT) colitis to derive temporal gene expression and splicing signatures in blood and colonic tissue in order to capture dynamics of colitis remission and relapse. We identify sub networks of patient-derived causal networks that are enriched in these temporal signatures to distinguish acute and chronic disease components within the broader molecular landscape of IBD. The interaction between the DSS phenotype and chronological time-point naturally defines parsimonious temporal gene expression and splicing signatures associated with acute and chronic phases disease (as opposed to ordinary time-specific differential expression/splicing). We show these expression and splicing signatures are largely orthogonal, i.e. affect different genetic bodies, and that using machine learning, signatures are predictive of histopathological measures from both blood and intestinal data in murine colitis models as well as an independent cohort of IBD patients. Through access to longitudinal multi-scale profiling from disease tissue in IBD patient cohorts, we can apply this machine learning pipeline to generation of direct patient temporal multimodal regulatory signatures for prediction of histopathological outcomes.
The development of an electropolymerized, molecularly imprinted polymer (MIP) sensor for insulin determination using single-drop analysis
Authors: Zidarič Tanja , Majer David , Maver Tina , Finšgar Matjaž , Maver Uroš
Published: January 2023

Step-by-step development of the MIP-SPCE sensor to determine insulin.
Synthesis of multi-module low density lipoprotein receptor class A domains with acid labile cyanopyridiniumylides (CyPY) as aspartic acid masking groups
Authors: Neumann Kevin , Vujinovic Alex , Kamara Saidu , Zwicky André , Baldauf Simon , Bode Jeffrey W.
Published: January 2023

Single and multi-module low density lipoprotein receptor class A domains (LA modules) were synthesized with new acid labile cyanopyridiniumylides (CyPY) as aspartic acid monomers, which do not form aspartimides during solid phase peptide synthesis.
Generation and reaction of alanyl radicals in open flasks
Authors: Tatunashvili Elene , Maloney Callan J. , Chan Bun , McErlean Christopher S. P.
Published: January 2023

The generation and Giese-type reaction of alanyl radicals under metal-free reaction conditions is described.
The copper-catalyzed oxidative radical process of site selective C–N bond cleavage in twisted amides: batch and continuous-flow chemistry
Authors: Govindan Karthick , Chen Nian-Qi , Chen Hsing-Yin , Hsu Sodio C. N. , Lin Wei-Yu
Published: January 2023

Copper-superoxo radical activation in twisted amides which mediates the aerobic oxidative process to produce primary amides by selective C–N bond cleavage in batch and continuous-flow method.
Slow magnetic relaxation in a homoaxially phosphine oxide coordinated pentagonal bipyramidal Dy(iii) complex
Authors: Kalita Pankaj , Ahmed Naushad , Moorthy Shruti , Béreau Virginie , Bar Arun Kumar , Kumar Pawan , Nayak Prakash , Sutter Jean-Pascal , Singh Saurabh Kumar , Chandrasekhar Vadapalli
Published: January 2023

Synthesis, structural characterization and combined experimental and theoretical magnetic properties of a new homoaxially phosphine oxide coordinated pentagonal bipyramidal complex, [(LN3O2Ph)DyIII(Cy3PO)2]·[BPh4] are reported.
A nitrosyl iron complex with 3.4-dichlorothiophenolyl ligands: synthesis, structures and its reactions with targets – carriers of nitrogen oxide (NO) in vivo
Authors: Pokidova Olesya V. , Novikova Veronika O. , Emel'yanova Nina S. , Kormukhina Alexandra Yu. , Kulikov Alexander V. , Utenyshev Andrey N. , Lazarenko Vladimir A. , Ovanesyan Nikolai S. , Starostina Arina A. , Sanina Natalya A.
Published: January 2023

Albumin, mucin and oxyhemoglobin act as carriers of the newly synthesized nitrosyl iron complex [Fe2(SC6H3Cl2)2(NO)4] and participate in its transformation.
Fate, uptake and gut toxicity of two colloidal silver products in mice: how micro X-ray fluorescence, micro X-ray absorption spectroscopy and near-infrared spectroscopy provide new insights in food nanotoxicology
Authors: Gillois Kevin , Rivard Camille , Levasseur-Garcia Cecile , Bezirard Valerie , Terrisse Helene , Leonard Renaud , Robbe-Masselot Catherine , Maguin Emmanuelle , Richard Mathias L. , Theodorou Vassilia , Ropers Marie-Helene , Mercier-Bonin Muriel , Robert Herve
Published: January 2023

Silver biodistribution and gut toxicity of two different colloidal silver products were evaluated in mice after oral exposure. Biophysics-based methodologies provided novel insights into (nano)silver uptake, fate and toxicological effects.
Evolution of singlet oxygen in peroxymonosulfate activation: a review
Authors: Dong Chencheng , Yi Qiuying , He Juhua , Xing Mingyang , Zhang Jinlong
Published: January 2023

Given that sulfate-radical-based advanced oxidation processes (SR-AOPs) have attracted great attention in recent years, PMS activation has been reckoned to be an alternative method to the Fenton process in environmental remediation.
Raw milk kefir: microbiota, bioactive peptides, and immune modulation
Authors: Baars Ton , van Esch Betty , van Ooijen Luuk , Zhang Zuomin , Dekker Pieter , Boeren Sjef , Diks Mara , Garssen Johan , Hettinga Kasper , Kort Remco
Published: January 2023

In this study we compared raw milk kefir to heated milk kefir and identified unique characteristics of raw milk kefir, including additional bacteria and yeasts, a higher peptide diversity, and a suppression of a food-allergic immune response.
Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice
Authors: Liu Jianming , Yang Na , Yi Xingcheng , Wang Guoqiang , Wang Cuizhu , Lin Hongqiang , Sun Liwei , Wang Fang , Zhu Dongdong
Published: January 2023

Ginsenoside Rg3 has a protective effect against AR. The gene-metabolite network that played the main role in AR mice under Rg3 treatment has been explored by the integrated metabolomic and transcriptomic strategy.
A novel sustainable PHA downstream method
Authors: Mondal Suchintan , Syed Usman T. , Gil Cátia , Hilliou Loic , Duque Anouk F. , Reis Maria A. M. , Brazinha Carla
Published: January 2023

A proposed greener approach for extraction of PHAs in comparison to methods using hazardous solvent.
Electrochemical radical–polar crossover diesterification of alkenes with carboxylic acids
Authors: Tan Yu-Fang , Yang Dan , Zhao Ya-Nan , Lv Jin-Feng , Guan Zhi , He Yan-Hong
Published: January 2023

An electrochemical method for the direct synthesis of 1,2-diester derivatives from abundant and readily available olefins and carboxylic acids is described. The method is clean and highly atom- and step-economical.
Recent progress in metal–organic frameworks (MOFs) for electrocatalysis
Authors: Li Cha , Zhang Hao , Liu Ming , Lang Fei-Fan , Pang Jiandong , Bu Xian-He
Published: January 2023

Recent progress of metal–organic framework (MOF) based catalysts in the electrocatalytic hydrogen evolution reaction, hydrogen oxidation reaction, oxygen evolution reaction, oxygen reduction reaction and nitrogen reduction reaction is summarized.
Recent progress in nucleic acid detection with CRISPR
Authors: Liu Frank X. , Cui Johnson Q. , Wu Zhihao , Yao Shuhuai
Published: January 2023

Critical development of CRISPR-based diagnostics coupled with nucleic acid amplification and amplification-free techniques; various purposes of CRISPR diagnostics including determination, quantification, multiplexed and point-of-care diagnostics.
Microporous poly- and monocrystalline diamond films produced from chemical vapor deposited diamond–germanium composites
Authors: Sedov Vadim , Martyanov Artem , Popovich Alexey , Savin Sergey , Sovyk Dmitry , Tiazhelov Ivan , Pasternak Dmitrii , Mandal Soumen , Ralchenko Victor
Published: January 2023

Microwave plasma assisted chemical vapor deposition was used for the formation of diamond–germanium composite films. By selective removal of the Ge phase, a series of porous polycrystalline and single-crystal diamond films and membranes were obtained.
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly
Authors: Suthar Jugal , Alvarez-Fernandez Alberto , Osarfo-Mensah Esther , Angioletti-Uberti Stefano , Williams Gareth R. , Guldin Stefan
Published: January 2023

In this work, we are investigating the impact of tailoring the active sites of a biosensor surface to mirror lateral analyte feature sizes, here extracellular vesicles. We relate enhanced sensitivity to reduced steric effects and provide guidelines for future design.
Competitive electronic effect of ligand substitution over the role of metal ions (Ni and Co) on unusual amine–imine interconversion in conjugated amine–ene–imine ligands
Authors: Bag Jayanta , Das Surajit , Mukherjee Souvik , Ghosh Prasanta , Pal Kuntal
Published: January 2023

Competitive required electron donating effect either from aryl group or metal–imine moiety could facilities the 1,5-proton transfer in the unusual amine–imine inter-conversion of conjugated amine–ene–imine ligands.
Novel (E)-3-(1-substituted-1H-indazol-5-yl)-N-hydroxypropenamides as histone deacetylase inhibitors: design, synthesis and structure–activity relationships
Authors: Doan Minh Sang , Park Eun Jae , Anh Duong Tien , Dung Do Thi Mai , Quang-Bao Le , Hai Pham-The , Oanh Dao Thi Kim , Tung Truong Thanh , Na Ik Ho , Kwon Joo Hee , Kang Jong Soon , Han Sang-Bae , Hai Dinh Thi Thanh , Nam Nguyen-Hai
Published: January 2023

Two series of N-hydroxybenzamides showed excellent HDAC inhibition and cytotoxicity against three human cancer cell lines, including SW620, PC3, and MDA-MB-231.
Treatment of glyphosate wastewater by Zr-amino bi-functionalized worm-like mesoporous silica absorbents
Authors: Xu Caili , Xia Ting , Li Ping , Yin Jianfei , Chen Liu , Chen Sufang , Chi Ru’an , Han Qingwen , Luo Xiaogang , Lyu Renliang
Published: January 2023

Low-cost HECMS was prepared to adsorb glyphosate by interaction between amino and glyphosate, and ligation between Zr4+ and P–O.
A highly efficient visible-light-driven photocatalytic fuel cell with ZnIn2S4/PANI/TiO2/Ti photoanode for simultaneous degradation of rhodamine B and electricity generation
Authors: Mou Jiaxin , Xu Yunlan , Zhong Dengjie , Chang Haixing , Li Jun , Xu Chunzi , Wang Hui , Shen Hongyu
Published: January 2023

The synergy effect realizes the rapid separation of photogenerated carriers and ultimately improves the photoelectric conversion efficiency of PFC.
Unprecedented Ir(iii) cationic complexes based on tridentate tetrazolate ligands: synthesis, photophysics and encapsulation in SiO2 nanoparticles
Authors: Troya José , Quesada-Moreno María Mar , Jiménez Juan-Ramón , Herrera Juan Manuel
Published: January 2023

Ir(iii) complexes derived from 2-(tetrazole-5-yl)-1,10-phenanthroline (phenttz) were prepared. The complex [Ir(tpy)(phenttz)]2+ was embedded within silica nanoparticles and its emissive properties improved.
The volatile chemistry of orchid pollination
Authors: Perkins James , Hayashi Tobias , Peakall Rod , Flematti Gavin R. , Bohman Björn
Published: January 2023

Orchids are amongst the most diverse of all plant families, and produce a wide array of volatile compounds for pollinator attraction.
Carrier separation in type-II quantum dots inserted in (Zn,Mg)Te/ZnSe nanowires
Authors: Baranowski Piotr , Szymura Małgorzata , Kaleta Anna , Kret Sławomir , Wójcik Maciej , Georgiev Rosen , Chusnutdinow Sergij , Karczewski Grzegorz , Wojtowicz Tomasz , Tomasz Baczewski Lech , Wojnar Piotr
Published: January 2023

Quantum dots consisting of an axial Zn0.97Mg0.03Te insertion inside a large-bandgap Zn0.9Mg0.1Te nanowire core coated with two radial shells: ZnSe/Zn0.9Mg0.1Te. The interface between dot and ZnSe shell is characterized by type-II band alignment.
Recent achievements toward the development of Ni-based layered oxide cathodes for fast-charging Li-ion batteries
Authors: Zhang Yuxuan , Kim Jae Chul , Song Han Wook , Lee Sunghwan
Published: January 2023

This review enhances a fundamental understanding of the degradation mechanisms of Ni-based layered cathodes under fast-charging conditions from atomic to electrode scales. Design strategies for enhancing fast-charging performance are also suggested.
Asp-containing actinomycin and tetracyclic chromophoric analogues from the Streptomyces sp. strain S22
Authors: Zhao Wanzhu , Wang Guangfei , Guo Lin , Wang Jingmin , Jing Congcong , Liu Ben , Zhao Feng , Zhang Shumin , Xie Zeping
Published: January 2023

First Asp-containing actinomycin and two unusual tetracyclic chromophoric analogues with potent cytotoxic and antibacterial activities from marine-derived Streptomyces sp. strain S22.
New long-wavelength D–π-A–π-D chalcone photoinitiator for visible light polymerization with photobleaching and biocompatibility properties
Authors: Gao Yanyang , Qu Jinqing
Published: January 2023

Four chalcones with excellent light absorption properties and biocompatibility have been designed and synthesized for visible light polymerization.
Luminescent (metallo-supramolecular) cross-linked lanthanide hydrogels from a btp (2,3-bis(1,2,3-triazol-4-yl)picolinamide) monomer give rise to strong Tb(iii) and Eu(iii) centred emissions
Authors: Hegarty Isabel N. , Bradberry Samuel J. , Lovitt June I. , Delente Jason M. , Willis-Fox Niamh , Daly Ronan , Gunnlaugsson Thorfinnur
Published: January 2023

The synthesis and study of the lanthanide luminescent 2,3-bis(1,2,3- triazol-4-yl)picolinamide (btp) based hydrogels F1 and F2 is described where Tb(iii) or Eu(iii) are also used to crosslink the btp units within the polymers.
DES: their effect on lignin and recycling performance
Authors: Li Penghui , Zhang Zihui , Zhang Xiaoxue , Li Kongyan , Jin Yongcan , Wu Wenjuan
Published: January 2023

Deep eutectic solvents (DES) are the most common method for pre-treating lignocellulose in the extraction and degradation of lignin. The development and application of efficient methods of DES recovery can significantly reduce the cost of biomass refining.
CuO nanorod arrays by gas-phase cation exchange for efficient photoelectrochemical water splitting
Authors: Zheng Zhi , Morgan Mikhail , Maji Pramathesh , Xia Xiang , Zu Xiaotao , Zhou Weilie
Published: January 2023

CuO nanorod arrays were synthesized by a novel gas-phase cation exchange method using ZnO nanorod arrays as the template, demonstrating promising photoelectrochemical water splitting performance.
The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination
Authors: Dong Pei , Li Ruomeng , He Shizhen , Zhang Qingqing , Shang Jinhua , Jiang Yuqian , Liu Xiaoqing , Wang Fuan
Published: January 2023

A compact and clamped CHA-control-HCR (CCH) circuitry system, specifically for amplified multi-microRNA imaging, is developed to precisely distinguish cancer cells from normal cells.
Effects of network junctions and defects on the crystallization of model poly(ethylene glycol) networks
Authors: Ohira Masashi , Nakagawa Shintaro , Sampei Ryotaro , Noritomi Takako , Sakai Takamasa , Shibayama Mitsuhiro , Li Xiang
Published: January 2023

While junction points drastically delay the crystallization of polymeric materials, network defects affect little.
An artificial neural network using multi-head intermolecular attention for predicting chemical reactivity of organic materials
Authors: Yoo Jaekyun , Kim Byunghoon , Lee Byungju , Song Jun-hyuk , Kang Kisuk
Published: January 2023

A new type of artificial neural network to predict the reaction rate constant from two molecular structures. An explainable model was constructed using the multi-head intermolecular attention technique.
High thermoelectric performance in entropy-driven Ge1−2x−yPbxSnxSbyTe
Authors: Das Animesh , Acharyya Paribesh , Das Subarna , Biswas Kanishka
Published: January 2023

An ultrahigh zT of 2.5 at 723 K is achieved in an entropy driven Ge0.84Pb0.025Sn0.025Sb0.11Te sample showing a promising output power density (PDmax) of ∼590 mW cm−2 at ΔT = 448 K in a fabricated double leg device.
Controlling the density of storable charge of surface faradaic layers on Fe2O3 photoanodes for solar rechargeable devices
Authors: Jiang Dongjian , Sun Xiao , Xue Mengfan , Wang Pin , Yao Yingfang , Luo Wenjun , Zou Zhigang
Published: January 2023

The density of storable charge (DOSC) is introduced as the number of charges stored in a surface faradaic layer of a semiconductor, and it can be used to describe the charge transfer kinetic process in semiconductor/electrolyte interfaces.
Re-entrant relaxor ferroelectric behaviour in Nb-doped BiFeO3–BaTiO3 ceramics
Authors: Yang Ziqi , Wang Bing , Brown Thomas , Milne Steven J. , Feteira Antonio , Wohninsland Andreas , Lalitha K. V. , Li Yizhe , Hall David A.
Published: January 2023

Re-entrant relaxor ferroelectric behaviour is identified in BiFeO3–BaTiO3 ceramics, yielding anomalous thermal variations in structural distortion and functional properties.
Facile synthesis of hyperbranched Eu-MOF structures for the construction of a CsPbBr3/Eu-MOF composite and its application as a ratiometric fluorescent probe
Authors: Lai Wenwei , Wu Chuanli , Han Xiuxun
Published: January 2023

A ratiometric fluorescence probe fabricated by encapsulating CsPbBr3 in the three-dimensional hyperbranched Eu-MOF structure exhibits remarkable sensitivity, good linearity, and high selectivity for DMF detection.
2D self-assembly ofo-OPE foldamers for chiroptical barcoding
Authors: López-Sicilia Irene , Ortuño Ana M. , Reine Pablo , Otero Dario , Martín-Romero María T. , Camacho Luis , Álvarez de Cienfuegos Luis , Orte Angel , Giner-Casares Juan J. , Miguel Delia , Cuerva Juan M.
Published: January 2023

2D films of enantiopure stapledo-OPEs have been used to develop a CPL-barcoding system free of photoselection artifacts. The use of both enantiomers makes the system easier and safer to read.
Inflammatory processes involved in NASH-related hepatocellular carcinoma
Authors: Cannito Stefania , Dianzani Umberto , Parola Maurizio , Albano Emanuele , Sutti Salvatore
Published: January 2023

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide. In the recent years nonalcoholic fatty liver disease (NAFLD) is becoming a growing cause of HCCs and the incidence of NAFLD-related HCCs is expected to further dramatically increase by the next decade. Chronic inflammation is regarded as the driving force of NAFLD progression and a key factor in hepatic carcinogenesis. Hepatic inflammation in NAFLD results from the persistent stimulation of innate immunity in response to hepatocellular injury and gut dysbiosis as well as by the activation of adaptive immunity. However, the relative roles of innate and adaptive immunity in the processes leading to HCC are still incompletely characterized. This is due to the complex interplay between different liver cell populations, which is also strongly influenced by gut-derived bacterial products, metabolic/nutritional signals. Furthermore, carcinogenic mechanisms in NAFLD/NASH appear to involve the activation of signals mediated by hypoxia inducible factors. This review discusses recent data regarding the contribution of different inflammatory cells to NAFLD-related HCC and their possible impact on patient response to current treatments.
Prevalence of Cognitive Impairment and Its Association With Hearing Loss Among Adults Over 50 Years of Age: Results From a Population-Based Survey in Santiago, Chile
Authors: Tamblay Natalia , Boggs Dorothy , Huidobro Barbara , Tapia-Mora Daniel , Anabalon Katherine , Delgado Carolina , Polack Sarah , Bright Tess , Torrente Mariela C.
Published: January 2023

Purpose:

The purpose of this study was to estimate the prevalence of cognitive impairment and explore its association with hearing loss and other sociodemographic and clinical risk factors, using an objective measurement of hearing levels, in adults over 50 years of age.

Method:

A population-based survey was completed in Santiago, Chile between December 2019 and March 2020. Participants were screened for cognitive impairment using the Short Chilean Mini-Mental State Examination and hearing levels were assessed with tonal audiometry (hearTest). Data on demographic, socioeconomic, and clinical characteristics were collected.

Results:

A total of 538 persons completed the assessment. The prevalence of cognitive impairment in the 50+ population was 9.3% (95% confidence interval [CI] [5.8, 14.7]). Cognitive impairment was significantly higher in individuals with any level of hearing loss (odds ratio [
OR
] = 2.19, 95% CI [1.00, 4.80], adjusted for age, sex, education, socioeconomic position [SEP], and head trauma). Subjects with hearing loss and who reported any use of hearing aids (16% of the sample) had a lower risk of cognitive impairment (
OR
of nonusers 3.64, 95% CI [1.00, 13.28], adjusted for age, sex, education, SEP, and head trauma).

Conclusion:

Strategies for addressing cognitive impairment should further explore the integration of early diagnosis of hearing loss and the regular use of hearing aids.
Multisource localization based on angle distribution of time–frequency points using an FOA microphone
Authors: Tao Liang , Jia Maoshen , Li Lu , Wang Jing , Xiang Yang
Published: January 2023

Multisource localization occupies an important position in the field of acoustic signal processing and is widely applied in scenarios, such as human‐machine interaction and spatial acoustic parameter acquisition. The direction‐of‐arrival (DOA) of a sound source is convenient to render spatial sound in the audio metaverse. A multisource localization method in a reverberation environment is proposed based on the angle distribution of time–frequency (TF) points using a first‐order ambisonics (FOA) microphone. The method is implemented in three steps. 1) By exploring the angle distribution of TF points, a single‐source zone (SSZ) detection method is proposed by using a standard deviation‐based measure, which reveals the degree of convergence of TF point angles in a zone. 2) To reduce the effect of outliers on localization, an outlier removal method is designed to remove the TF points whose angles are far from the real DOAs, where the median angle of each detected zone is adopted to construct the outlier set. 3) DOA estimates of multiple sources are obtained by postprocessing of the angle histogram. Experimental results in both the simulated and real scenarios verify the effectiveness of the proposed method in a reverberation environment, which also show that the proposed method outperforms reference methods.
Smooth commutation of brushless DC motor by model‐free predictive current control without back‐EMF estimation
Authors: Moradpour Reza , Tavakoli Abdolreza
Published: January 2023

This study presents a new predictive control approach for brushless DC (BLDC) motor to smooth its commutation process. The proposed predictive control method is applied to the BLDC motor's equivalent DC current. Therefore, this method utilises only one prediction equation, which means less calculation than the standard predictive control schemes. Here, the equivalent DC current equation is defined according to the model‐free control theory to remove the back‐EMF voltage estimation from the control system. In consequence, the proposed predictive DC current control (DC‐PCC) has a smooth commutation. Because of applying the model‐free theory, both commutation and non‐commutation periods of the BLDC motor have similar dynamic equations. Hence, one simple prediction equation can be utilised for both periods. Besides, the proposed method has less computational burden due to using only one prediction equation and removing the back‐EMF estimation process. To validate the proposed model‐free DC‐PCC, experimental tests are performed, and the results are discussed in this research.
Medical image blind super‐resolution based on improved degradation process
Authors: Shao Dangguo , Qin Li , Xiang Yan , Ma Lei , Xu Hui
Published: January 2023

Clinical diagnosis has high requirements for the resolution of medical images, but most existing medical images super‐ resolution (SR) methods are performed under a known or specific degradation kernel. However, the difference between the actual degradations and their assumed degradation kernels results in a severe performance drop for the advanced SR methods in real applications. This paper proposes a medical image blind super‐resolution model (Med‐BSR) based on an improved degradation process to handle this issue. The model makes each of the degradation factors in medical image blind SR, such as blur, noise, and downsampling, more complex and practical. Specifically, the authors use the random select/combine strategy to randomly arrange and combine the type and order of each degradation factor, which significantly expands the degradation space. The authors also improved the loss function of the primary enhanced super‐resolution generative adversarial networks (ESRGAN) network. The extensive experimental results demonstrate that the authors’ designed model can accurately restore the natural degradation process, which can reconstruct high‐quality SR medical images. It also has a good generalization ability to realistic images simultaneously.