bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of blood extraction and ecophysiological experiments on stress in adult males of Liolaemus attenboroughi
Authors: Duran Fernando , Medina Marlin S. , Ibargüengoytía Nora R. , Boretto Jorgelina M.
Published: September 2024

Stress during laboratory experiments can affect the outcomes of ecophysiological studies. The serum corticosterone concentration (CORT), the leukocyte profile, heterophil/lymphocyte ratio (H/L), and the presence of blood endoparasites were analyzed as a proxy of stress and immunological state in adult males of the lizard Liolaemus attenboroughi, endemic to Patagonia, Argentina. The results of the ecophysiological variables (preferred temperature, running speed, locomotor endurance, and body condition index, BCI) were analyzed in relation to stress indicators obtained from blood samples taken at three different times: at capture, and on the third and seventh days in the laboratory. Males at capture showed a high percentage of lymphocytes and heterophils and a low of basophils, monocytes, and eosinophils. Haemogregorina-type endoparasites have been recorded in the genus Liolaemus for the first time. The proportion of infected males remained stable during captivity; however, these males showed higher CORT levels, increased percentages of basophils, and decreased percentages of lymphocytes. There was a significant increment in CORT and H/L, and a decrease in BCI during laboratory experiments, compared with baseline values at capture. The performance was not related to the CORT or the repeated blood sampling. The BCI decreased, possibly due to energy reserve mobilization caused by acute stress. This study shows that blood extraction and ecophysiological experiments over 7 days have a minor effect on the stress indicators used.
Desafios e oportunidades para a política de saúde
Authors: Oliveira Vanessa Elias de , Coelho Vera Schattan , Levi Maria Luiza
Published: September 2024

Objetivo: Analisar os desafios e caminhos para a política municipal de saúde.
Estado da arte: A despesa pública com saúde vem se mantendo em patamar inferior ao necessário para o funcionamento do SUS em condições aceitáveis, e sua distribuição é desigual. Além disso, políticas importantes na área foram desestruturadas nos últimos governos federais e só agora começam a ser reconstruídas. Esse cenário traz desafios à gestão pública dos municípios.
Originalidade: A partir da reconstrução do desenvolvimento da política de saúde nos anos recentes em relação a aspectos como desigualdades territoriais, regionalização e financiamento do SUS, o artigo propõe caminhos para o aprimoramento das políticas públicas municipais em saúde.
Impactos: O artigo colabora para o aprimoramento de políticas públicas locais baseadas em evidências, a partir da ênfase em aspectos como a importância da melhor articulação federativa e a reflexão sobre como construir melhores capacidades estatais locais em saúde, inclusive em temas emergentes.
Políticas públicas e desafios para a gestão local
Authors: Abrucio Fernando Luiz , Grin Eduardo
Published: September 2024

Existem 5.569 municípios no Brasil, o que não é nada trivial, considerando que no federalismo brasileiro os governos locais são dotados de ampla autonomia garantida constitucionalmente. Conforme a Constituição Federal (CF/88), a organização político-administrativa da Federação compreende a União, os estados, o Distrito Federal e os municípios, todos autônomos entre si, conforme o artigo 1º, gerando um pacto indissociável1. O município é uma unidade integrante do sistema federativo e não está subordinado a nenhum nível superior de governo, como costuma ser a regra na maioria das federações, a exemplo dos Estados Unidos, México, Argentina e Canadá, onde municípios são criações dos estados ou das províncias.
THE ARTISTIC ACTIVITY OF THEOPHANES ΤΗΕ CRETAN IN WESTERN THESSALY AND THE EMERGENCE OF THE ‘‘CRETAN SCHOOL’’ OF PAINTING IN OTTOMAN GREECE
Authors: Vapheiades Konstantinos
Published: September 2024

One of the leading Cretan artists of the sixteenth century, whose production has not been thoroughly and critically examined yet, was Theophanes Strelitzas. The following article will expand our knowledge of his prolific artistic activity under monastic patronage in West Thessaly, already known from the katholikon of the Monastery of St. Nicholas Anapausas. In the first place, unpublished icons which pertain to Theophanes’s artistic idiom will be presented from ecclesiastical collections of the wider region. Based on this evidence, the article will raise questions concerning the emergence of the ‘‘Cretan School’’ of painting in Ottoman Greece. This discussion aims at a critical questioning of the prevailing art historical narrative on the Cretan style’s dissermination in Thessaly and continental Greece in general.
Experiences Using Media Health Claims to Teach Evidence-Based Practice to Healthcare Students: A Mixed Methods Study
Authors: Elvsaas Ida-Kristin Orjasaeter , Myrhaug Hilde Tinderholt , Garnweidner-Holme Lisa , Kasper Jürgen , Dahlgren Astrid , Molin Marianne
Published: September 2024

Background A multifaceted and interactive teaching approach is recommended for achieving proficiency in evidence-based practice, with critical thinking considered vital for connecting theory and practice. In this context, we advocate the strategic use of health claims in the media to promote critical thinking, complemented by a blended learning approach and a group exam. Method We conducted a convergent mixed methods study, including a cross-sectional survey with structured and open-ended questions as well as focus group interviews, at Oslo Metropolitan University, during the 2020-2021 academic year. Participants were bachelor’s students in healthcare. We employed a blended learning approach, combining digital learning resources, teaching in critical assessment of health claims and evidence-based practice, and a concurrent group exam assignment centered around media health claims. The outcome measures included students’ experiences integrating health claims into evidence-based practice teaching and their experiences with teaching approaches and the group exam. Results Out of 465 participants, 136 (29.2%) responded to the structured questions in the survey. In response to the open-ended questions within the survey, 109 (80.1%) of the respondents shared positive experiences about the course, while 98 (72%) suggested improvements. Additionally, 25 students participated in focus group interviews. Synthesizing the results, we found that students viewed the inclusion of health claim assessment as a useful entry point for learning evidence-based practice. In addition, the students identified both the blended learning design and the group exam as contributors to a positive perception of learning outcomes from the course. Conclusions Based on student feedback, integrating critical reflection on media health claims into evidence-based practice education, alongside a blended learning approach and a group exam, may be beneficial in teaching evidence-based practice to bachelor’s healthcare students. However, further rigorous study designs are needed to objectively assess the effect of the course on learning outcomes. Registration DOI 10.5281/zenodo.6985449
Collaborative Policymaking: a qualitative systematic review of advice for policymakers
Authors: Cairney Paul , Toomey Claire
Published: September 2024

Background Complex policy problems are not amenable to simple solutions by a few powerful policy actors in one central government. They require collaboration across government and between actors inside and outside of government. However, this requirement for collaboration is no guarantee of collective action. Further, it is difficult to know how to collaborate effectively. We searched the academic and grey literature for advice on how to foster collaborative policymaking. Methods We conducted a qualitative systematic review (2024) of peer reviewed journal articles (Web of Science) and grey literature reports (Policy Commons). Each article or report had to inform advice on collaborative policymaking. We used an immersive and inductive approach to identify key themes and relate the results to well-established insights from policy theories. Results 86 texts meet the inclusion criteria (49 Web of Science, 37 Policy Commons). Most provide broad definitions of collaborative policymaking, which are similar to definitions of collaborative governance (and connected aims such as policy co-creation). Many assert or assume that greater collaboration, across and inside/outside of government, will improve policymaking and policy. Few individual studies give advice on how to collaborate effectively, but they combine to identify common features of collaboration. Conclusions We synthesise the available advice to identify five main features of collaborative policymaking: plan and prepare to collaborate, such as by designing rules and allocating resources; create a sense of collective purpose, such as by setting a boundary around the collaboration and co-producing a common vision; foster creative methods to visualise collaboration and design policy; create new forums to supplement formal collaboration; and clarify the roles and skills essential to each collaborative task.
An assessment of variation in quality of hypertension guidelines across income settings using the AGREE II tool
Authors: Philip Richu , Janssen Carolina , Jose Arun , Beaney Thomas , Clarke Jonathan
Published: September 2024

Background Hypertension affects over one billion people worldwide, posing a significant global health burden. Clinical practice guidelines could play a key role in guiding healthcare providers in improving hypertension management. However, how the quality of hypertension CPGs differs across country income settings is not well understood. This study aims to explore variation in the quality of hypertension CPGs, comparing low-, middle-, and high-income countries, using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool. Methods A Medline and grey literature search was conducted to identify hypertension CPGs in English from every country from January 2012 to September 2022. Two reviewers independently assessed and scored each CPG against the AGREE II tool. Results were described and the Kruskal-Wallis test was used to test for statistically significant difference in the domain scores across country income groups. Results Forty-three CPGs were included for analysis from across income settings. Guidelines from HICs scored higher in four out of the six domains. The highest scoring domain was 4: “clarity and presentation” (median score 83%), the lowest scoring was domain 6 “editorial independence” (median score 0%). Statistically significant differences between income settings were observed for domain 3 “rigour of development” (p <0.001), domain 4 “clarity and presentation” (p = 0.03) and domain 6 “editorial independence” (p = 0.04). Conclusions Whilst some variation exists in guideline quality across country income levels, the greatest degree of variation exists across the domains of the AGREE II tool. Global efforts to improve the quality of hypertension guidelines should focus on the transparent statement of editorial independence of guideline committees and apply rigorous replicable methods in the authoring of guidelines. Establishing national and international communities of practice to collaborate across income settings may reduce duplication of resource, allow for shared learning and promote the development of high-quality hypertension CPGs.
The genome sequence of barren brome, Bromus sterilis L. (Poaceae)
Authors: Christenhusz Maarten J. M. ,   Royal Botanic Gardens Kew Genome Acquisition Lab,   Plant Genome Sizing collective,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: September 2024

We present a genome assembly from an individual Bromus sterilis (the barren brome; Streptophyta; Magnoliopsida; Poales; Poaceae). The genome sequence has a total length of 2,677.90 megabases. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 523.28 kilobases and 136.96 kilobases, respectively. Gene annotation of this assembly on Ensembl identified 29,147 protein-coding genes.
The genome sequence of the Bindweed Bent-wing moth, Bedellia somnulentella (Zeller, 1847)
Authors: Hammond James , Roman Maldonado Irene Fabiola ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: September 2024

We present a genome assembly from an individual female Bindweed Bent-wing moth, Bedellia somnulentella (Arthropoda; Insecta; Lepidoptera; Bedelliidae). The genome sequence has a length of 549.00 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the W and Z sex chromosomes. The mitochondrial genome has also been assembled and is 16.62 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,959 protein-coding genes.
The genome sequence of the European conger eel, Conger conger (Linnaeus, 1758)
Authors: Adkins Patrick , Brittain Rachel , Harley Joanna , Modepali Vengamanaidu ,   Marine Biological Association Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: September 2024

We present a genome assembly from an individual Conger conger (the European conger eel; Chordata; Actinopteri; Anguilliformes; Congridae). The genome sequence spans 1,136.40 megabases. Most of the assembly is scaffolded into 19 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 18.86 kilobases in length.
SOME BIOLOGICAL AND ECOLOGICAL FEATURES OF HYPODERMA LATREILLE, 1818 IN TAVUSH REGION OF ARMENIA
Authors: Grigoryan Valery V. , Shcherbakov Oleg V. , Abrahamyan Viktor V. , Yeribekyan Spartak V. , Grigoryan Liana H.
Published: September 2024

Background. Cattle hypodermosis is a chronic parasitic disease (entomosis) that occurs as a result of parasitizing the larvae of warble flies in the body of animals. Disease is common in more than 55 countries of the world, causing great economic damage. It is considered as a parasitic disease with a certain zoonotic potential.
Purpose. To conduct research on biological and ecological features of the warble flies that determines certain epidemiological traits of the caused pathology in Tavush Region of Armenia.
Materials and methods. The observations were carried out in Tavush Region, and the experiments were carried out at the Research Center for Veterinary Medicine and Veterinary Sanitary Expertise at the Armenian National Agrarian University.  The warble flies marked with stain, were released at a distance of 0.5 to 1.5 km from livestock farms with subsequent search and trapping of insects, located on pastures and on the skin of animals. Generally, 275 warble flies were released. Warble fly activity was evaluated visually counting the comparative number of flying insects at the fixed point per minute at different times of the day, as well as animal anxiety state caused by warble flies was identified. Statistical processing of experimental data was performed by means of “Vassart.net” online calculator.
Results. Female warble flies Hypoderma bovis flew up to 12.1 km, while female warble flies H. lineatum did it up to 8.6 km. Females of H. bovis and H. lineatum demonstrated various spatial and circadian flying activity that depends on season, and altitude above the sea level. Spring generation of warble flies is more resistant to low air temperatures compared to the summer generation. Mild and humid summers, as well as an increase in the number of animals, contribute to an increase in the population of warble flies, while high temperature and high soil moisture contribute to the mass death of warble fly pupae developing in the ground.
Conclusion. The research data cited in the article, detect the presence of a wide range of biocenotic factors that determine the epidemiology of cattle hypodermosis in the Tavush region of the Republic of Armenia. Cattle hypodermosis control plan was designed based on the results of the research, as well as natural and climatic conditions of Tavush region. Pasture prevention activities and periodic treatment of the cattle with insecticides were emphasized.
FEATURES OF THE PIGMENT APPARATUS OF THE PHOTOSYNTHETIC SYSTEM OF ELMS AND GLEDICHIAS IN FOREST AMELIORATION AND PROTECTIVE AFFORESTATION
Authors: Kuzmin Petr A. , Krylov Pavel A.
Published: September 2024

Background. Woody plants within southern Russia are impacted by drought, which leads to changes in their living conditions. The living condition depends on the work of the pigment apparatus of the photosynthetic system and leaf mesostructure. The purpose of this work was to reveal the functioning features of the pigment apparatus of the photosynthetic system and the structural organization in Ulmus laevis, Ulmus parvifolia, and Gleditsia triacanthos leaves.
Result. The study revealed new species-specific features of the leaf pigment apparatus of the photosynthetic system and the structural organization in "healthy and weakened" plants under stress conditions.
Methods. The vital condition of trees was evaluated by visual analysis of crown parameters according to the V.A. Alekseeva’s method. Quantitative data were processed using the Statistica 12.0 program.
Conclusion. During the analysis of genes and their products, the effect on the work of the pigment apparatus of the photosynthetic system was shown in normal and under stress. In this regard, it is necessary to further search for DNA markers of these genes and their degree of expression involved in the mechanisms of adaptation to adverse environmental factors. The study of the leaf pigment apparatus of the photosynthetic system and the structural organization in woody plants can be used to obtain new genotypes with economically valuable features, bioindication, and selection of optimal regimes for their cultivation.
Acknowledgments. The research was carried out within the state assignment of the Ministry of Science and Higher Education of the Russian Federation, No. FNFE-2022-0009 "Search for selection and valuable genetic material to create new genotypes of woody shrubs by molecular breeding methods" and No. FNFE-2022-0022 "Search and management of expression patterns of forest and cultivated plant genes responsible for adaptation to unfavorable environmental factors and productivity".
GRAIN YIELD AND SIDERAL MASS OF FIELD CROPS IN CROP ROTATIONS OF THE LOWER VOLGA REGION
Authors: Seminchenko Elena V.
Published: September 2024

Background. For the first time in the abiotic conditions of the Lower Volga region on light chestnut soils, new methods of biologization of soil fertility preservation and specialized field crop rotations based on the replacement of pure steam with sideral steam with little–studied crops for green fertilizer – biennial yellow clover, oats and phacelia were developed and studied; the structure of sown areas includes cultures of various biological groups, including cereals, legumes, oilseeds, rowed and perennial legumes; in addition to siderates, organic fertilizers are used in the form of straw and crop –root residues of cultivated crops.
The purpose of the work is the influence of pure and sideral steam on the yield of field crops
Materials and methods. The study of the influence of sideral masses on the yield of grain crops in field crop rotations in the conditions of the Lower Volga region.
Results. According to the conducted research, it has been established that biologized crop rotations are the first major stage in the transition to organic farming in the Volgograd region. The best option for the soils of the dry-steppe zone of chestnut subzones of light chestnut soils of the Lower Volga region is a four-field biologized field crop rotation and a five-field crop rotation with sideral steam (donnik).
Conclusion. Data analysis showed that the best indicators of winter wheat yield were obtained for pure and sideral (sweet clover) pairs - 1.8 t/ha, chickpeas for the predecessor winter wheat in the five–field crop rotation - 0.87 t/ha and spring barley for the predecessor chickpeas – 1.48 t/ha.
THE INFLUENCE OF MULTICOMPONENT WINTER WHEAT SEED PROTECTANTS ON ITS PRODUCTIVITY AND QUALITY
Authors: Gulidova Valentina A. , Shchuchka Roman V. , Zubkova Tatyana V. , Zakharov Vyacheslav L.
Published: September 2024

We studied combined suspension compositions prepared by liquid-phase mechanical treatment based on the fungicides difenoconazole, tebuconazole, imazalil, fludioxanil, thiabendazole, prochloraz, sedoxan and the insecticides thiamethoxam, imidacloprid, plant growth regulators Enershanse, which showed a wide range of biological activity in field conditions. It was established that the main indicators of the quality of the final product - the nature of the grain, the amount of protein and gluten, glassiness, and the quality of gluten - depended on the fungicidal and insecticidal effects on the phytosanitary condition of winter wheat crops. All studied drugs had a protective effect. They contributed to the disinfection of winter wheat seeds from seed and soil pathology and harmful insects of the early period of plant development. It was found that for effective treatment of winter wheat seeds, it is best to use insectofungicidal preparations containing several components of different chemical classes. It was found that pre-sowing treatment of winter wheat seeds with a suspension composition of thiamethoxam + sedaxan + fludioxonil + tebuconazole in the form of Vibranse Integral, suspension concentrate provided the greatest increase in grain yield by 0.49 t/ha (7.3%) with a control yield of 6.74 t/ha. The use of this drug ensures a particularly high protein content in the grain (16.07%) and gluten (36.8%) of the first quality group. We have established diverse positive effects of the drug Vibranse Integral, manifested in enhancing the growth processes of the root system due to the presence of the sedaxane molecule, the purpose of which is aimed at the formation of a healthy and well-developed root system, increasing the stress resistance of plants to abiotic factors, and the manifestation of a good protective effect in relation to soil and seed infections. We determined the lowest, relative to other studied drugs, yield (6.17 t/ha) from the use of a suspension composition of thiamethoxam (262.5 g/l) + difenoconazole (25 g/l) + fludioxonil (25 g/l (Celest Top), but the grain was of high quality. All other seed protectants occupied an intermediate position between the above-mentioned drugs.
SPRING WHEAT IN THE DRY CLIMATE OF THE LOWER VOLGA REGION OF RUSSIA
Authors: Solonkin Andrey V. , Sukhareva Elena P. , Belikina Anna V.
Published: September 2024

Background. The growing of spring wheat in arid conditions is a difficult task because the biological characteristics of the crop and its demands on moisture reserves. The need for sowing spring wheat in the spring is dictated by the possible death of winter grains in winter.
Purpose. To determine the most adaptive varieties of spring wheat with high yield and good quality for cultivation in the dry climate of the Lower Volga region of Russia.
Methods. To achieve this goal, an environmental test of spring wheat varieties was carried out by us; the harvest results were processed by analysis of variance. To characterize weather conditions, the hydrothermal coefficient was calculated according to T.G. Selyaninov. An analysis of the ability of varieties to adapt to local climatic conditions was carried out using the coefficient of adaptability, stress resistance and compensatory ability of varieties. The graph was constructed and statistical data processing was carried out in Microsoft Excel 2008.
Result. As a result of the research work, it was established that on average over three years of research, the highest yield of spring wheat was in the following varieties: Saratovskaya 73 -1.65 t/ha, Kamyshinskaya 3 - 1.32 t/ha, Bezenchukskaya 205 - 1, 4 t/ha. Processing of spring wheat harvest data are used by dispersion analysis made it possible to determine that the gross harvest of the crop is largely influenced by meteorological conditions, up to 42.0%, the choice of variety is about 19.7%, and agrotechnological and other environmental factors are 38.2%. It can be noted that spring soft wheat in the conditions of the Lower Volga region is capable of producing grain yields of good quality with large grains from 31.2 to 36.4 g of 1000 grains.
Analysis of indicators of the level of resistance to drought conditions shows that the most stress-resistant varieties are: Zinaida - 0.06 t/ha, Kamyshinskaya 3 - 0.24 t/ha, Albidum 188 - 0.24. The varieties that have the highest genetic flexibility in the conditions of the Lower Volga region are: Saratovskaya 73 - 1.72 t/ha, Bezenchukskaya 205 - 1.5 t/ha and Kamyshinskaya 3 - 1.32 t/ha. The spring wheat varieties Bezenchukskaya 205 have the highest responsiveness to changes in crop growth conditions - 0.12, Dobrynya is in second place - 0.14, Albidum is in third place, Kamyshinskaya 3 - 0.15. The adaptability coefficient is higher than 1 in the varieties Albidum 188, Kamyshinskaya 3, Saratovskaya 73, Prokhorovka, Zinaida.
Conclusion.  The varieties Saratovskaya 73 and Kamyshinskaya 3 are distinguished by yield, stress tolerance, genetic adaptability to dry climate.
Intangible cultural heritage in practice Between appreciation and appropriation
Authors: Czerwińska Kinga
Published: September 2024

This text deals with selected issues related to the use of cultural heritage undertaken from the position of stakeholders. Theoretical considerations are based on selected examples of craft skills used in safeguarding intangible heritage. The lively activity of dissemination and promotion of these skills is largely linked to the implementation of the 2003 UNESCO Convention on the Safeguarding of the Intangible Cultural Heritage and the consequent creation of the National List of Intangible Cultural Heritage. In particular, the text analyses aspects of the nomination process of heritage bearers and the outcomes of such a role. More broadly, the article highlights issues related to the boundary between cultural heritage appreciation and appropriation, as well as heritage management and community empowerment.
From Hair-Pulling to Trichobezoars and Rapunzel Syndrome: A Comprehensive Review of Trichotillomania
Authors: Rosińska Kamila , Łojewska Julia Natalia , Janicka Ewelina Justyna , Perko Agnieszka , Rosiński Mateusz , Niedźwiedzka Monika , Bochenek Oliwia , Koper Mateusz
Published: September 2024

Introduction: Trichotillomania (TTM) is an obsessive-compulsive disorder characterized by the uncontrollable pulling of hair from various parts of the body, most commonly from the scalp, eyebrows, and eyelashes. Clinical manifestations of TTM include patchy alopecia, uneven hair shaft growth, and characteristic changes visible in trichoscopy, such as the presence of black dots, twisted hairs, split ends, and hairs shaped like exclamation marks.
The etiology of TTM is complex and involves genetic, neurological, and psychological factors. In some patients, TTM co-occurs with trichophagia, leading to the formation of trichobezoars in the gastrointestinal tract. In extreme cases, such as Rapunzel Syndrome, bezoars can lead to intestinal obstruction.
Treatment for TTM is multifaceted and includes both psychotherapeutic and pharmacological interventions.
Objective: The objective of this study is to provide a comprehensive review of trichotillomania (TTM), with a particular focus on its clinical symptoms, etiology, diagnostics, and treatment methods. The aim is to understand this obsessive-compulsive disorder, its impact on patients' lives, and its connections to serious complications such as trichobezoars and Rapunzel Syndrome.
Materials and Methods: The study utilized analyses of scientific research, review articles, and reports concerning trichotillomania (TTM), trichobezoars, trichophagia, and Rapunzel Syndrome. It is primarily based on data from PubMed, Google Scholar, Cochrane Library, and studies published between 2000 and 2024, focusing on the diagnostics, etiology, and treatment of TTM and related disorders.
Conclusions: The purpose of this study is to provide a comprehensive review of the current knowledge on trichotillomania, including its clinical symptoms, etiology, diagnostics, and treatment methods, while considering serious complications such as trichobezoars and Rapunzel Syndrome.
Hair Graying: Mechanisms, Prevention, and Innovative Treatment Strategies – literature review
Authors: Do Monika Kienanh , Kazimierska Karolina , Zaliwska Dominika , Kraszkiewicz Adrianna , Paduszyńska Natalia , Gonciarz Marta Justyna , Adamiec Dominika Karolina , Dąbrowska Anna , Kamińska Monika Anna , Czach Magdalena
Published: September 2024

Hair graying, or canities, is a complex biological process characterized by the progressive loss of hair pigment, often leading to aesthetic and psychological concerns. This review delves into the multifactorial nature of hair graying, examining the underlying biochemical and physiological mechanisms. Key contributors include oxidative stress, genetic and environmental factors, and disturbances in melanogenesis and signaling pathways such as Notch and Kit. Our extensive literature review from PubMed, involving 33 scientifically rigorous papers, explores the efficiency of various strategies aimed at delaying or preventing hair graying. We highlight the roles of antioxidants, lifestyle modifications, and advanced therapeutic approaches like genetic therapy and liposome delivery systems. Additionally, we explore the impact of diet and UV protection, among other factors, on maintaining hair pigmentation. This review underscores the intricate interplay of biochemical processes in hair graying and sheds light on promising interventions for managing this natural yet often unwelcome sign of aging.
Conservative treatment of adolescent idiopathic scoliosis (AIS): A narrative review of current evidence and implications for clinical practice
Authors: Błachnio Klaudia , Kopciał Szymon , Piecuch Dawid , Hańczyk Edyta
Published: September 2024

Introduction and purpose: Adolescent idiopathic scoliosis (AIS) is characterized by lateral curvature, vertebral rotation, and disruption of physiological curvature of the spine with the Cobb angle ≥10°. AIS affects 1-3% of children aged 10-16 years, representing the most common form of idiopathic scoliosis. Diagnosis of AIS is by exclusion and can be suspected based on Adams forward bend test and scoliometer. Untreated AIS can lead to serious consequences, such as progression of the deformity, back pain, reduced respiratory and cardiovascular function. The aim of this review is to update overview of conservative treatment options.
Description of the state of knowledge: AIS treatment guidelines from the Scoliosis Research Society (SRS) and the Scientific Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) advocate for observation, bracing, or surgery depending on curve severity, with a focus on avoiding spinal fusion when possible. Additionally, SOSORT recommends scoliosis-specific physiotherapy exercises for smaller curves or as an adjunct to bracing. Conservative treatment aims to prevent curve progression, manage respiratory and spinal complications, and improve quality of life.
Conclusions: AIS can significantly impair the physical and psychosocial well-being of young patients, with potential long-term consequences extending into adulthood Individualized treatment plans and patient/parent education are crucial for optimal outcomes. Schroth exercises are superior to Core Stabilization (CS) exercises in reducing Cobb angle, trunk rotation and improving spinal mobility, cosmetic trunk deformities and quality of life. CS exercises are more effective in increasing peripheral muscle strength, reducing pain and correcting vertebral rotation.
Experimental Success in Marburg Virus Vaccination
Authors: Dydyk Martyna , Nowak Aleksandra
Published: September 2024

The Marburg virus (MRV), classified within the Filoviridae family, was initially identified in 1967, precipitating Marburg virus disease (MARV), a severe and often fatal hemorrhagic fever. With its pronounced infectiousness, high mortality rate, and proclivity for epidemic outbreaks, MARV stands as a formidable public health menace. Despite extensive sporadic outbreaks and its designation as a priority disease, the quest for efficacious drugs or vaccines against MRV remains an ongoing challenge. Nonetheless, the relentless pursuit of scientific inquiry, augmented by the innovative application of immunoinformatics, is propelling forward vaccine development endeavors. Current vaccine candidates, spanning from VSV-based formulations to virus-like particle vaccines, exhibit encouraging outcomes in preclinical and clinical evaluations, boasting notable efficacy and safety profiles. Furthermore, the exploration of multivalent vaccine strategies, designed to target a spectrum of hemorrhagic fever viruses, holds promise in fortifying pandemic preparedness efforts. Immunoinformatics assumes a pivotal role in this context, offering predictive insights into vaccine candidate selection and optimization, thereby facilitating expedited development tailored to diverse demographic cohorts. The integration of computational modeling techniques into vaccine development paradigms represents a transformative avenue for effectively controlling MRV outbreaks on a global scale. Sustained collaboration and continued research endeavors are imperative to fully harness the potential of these advancements in confronting the formidable challenge posed by the lethal Marburg virus and safeguarding global public health.
Semaglutide: A revolution in the treatment of obesity and prevention of cardiovascular disease
Authors: Bilska Wiktoria , Żydek Ada , Ciułek Urszula , Paduch-Jakubczyk Wiktoria , Dubińska Michalina , Zduńczyk Wiktoria , Dobosz Anna
Published: September 2024

Introduction and Objective: Obesity represents a significant public health concern in the 21st century, with a substantial burden of disease attributable to its complications, including type 2 diabetes, hypertension, and cardiovascular disease. The objective of this review is to evaluate the efficacy and safety of semaglutide, a GLP-1 receptor agonist, in the treatment of obesity and its impact on cardiometabolic risk factors.
The Review and Methods: This review is based on an analysis of the scientific literature, including meta-analyses and clinical trials. The PubMed, Scopus and Web of Science databases were searched for publications up to 2023.
Abridged Description of the State of Knowledge: The efficacy of semaglutide in reducing body weight in patients with obesity is supported by evidence from clinical trials. Its mechanism of action includes the delay of gastric emptying and the reduction of hunger. The drug has been demonstrated to exert a beneficial effect on the lipid profile and blood pressure, thereby reducing the risk of cardiovascular disease. The adverse effects, which are primarily gastrointestinal in nature, are typically mild and resolve with treatment.
Summary: Semaglutide represents a promising therapeutic option for obese patients, offering an effective means of reducing body weight and improving cardiometabolic parameters. However, further studies are required to evaluate the long-term effects of this therapy and its application in different patient populations.
Keywords: Semaglutide, obesity, weight reduction, GLP-1, cardiometabolic risk factors, drug treatment.
Prywatna książka? O materialnej postaci dziennika wojennego Andrzeja Bobkowskiego
Authors: Nowak Maciej
Published: September 2024

Artykuł poświęcony jest interpretacji dziennika Andrzeja Bobkowskiego z lat 1939–1946 w ujęciu biograficznym, wspomaganym materialną analizą filologiczną. Oznacza to, że wybrane zagadnienia zostały omówione w kontekście ewolucji świadomości pisarskiej autora, z uwzględnieniem jego aktywności pozapisarskiej, co znajduje odbicie w podejściu do materialnych nośników zapisów, sposobu, w jaki są one traktowane, oraz aplikowanych strategii redakcyjnych. Służy to podkreśleniu ścisłego oraz poniekąd zwrotnego charakteru relacji między praktyką piśmienną a sferą biograficzną. W centrum uwagi badacza znajdują się oznaki „literackości” czy też „książkowości” nadawane przez Bobkowskiego jego dziennikowi. Na podstawie analiz tych oznak, zarówno o charakterze materialnym, jak i treściowym, badacz stawia tezę o intencjonalnym przekształcaniu prywatnej serii zapisów w całość, którą nazywa „prywatną książką”.
Leopolda Buczkowskiego zapiski wojenne. Kilka uwag z perspektywy edytora
Authors: Libich Maciej
Published: September 2024

Artykuł stanowi rekapitulację problemów, z jakimi musi zmierzyć się edytor zapisków wojennych Leopolda Buczkowskiego (1905–1989). Autor szkicu, inspirując się teoriami z zakresu antropologii literatury i krytyką genetyczną, omawia materialne i pozatekstowe aspekty notatek czasu okupacji, które jego zdaniem domagają się odzwierciedlenia w edycji. Podejmuje też krytykę dotychczasowych opracowań dzienników Buczkowskiego, zwracając uwagę na niewystarczające zainteresowanie edytorów takimi kwestiami jak materiały piśmiennicze, którymi posługiwał się Buczkowski. Wreszcie wspomina o pomijanym dotąd przez badaczy maszynopisie utworu Buczkowskiego pod tytułem Rafał Bajc, postulując uwzględnienie go jako kontekstu dla wojennych zapisków.
Leona Getza utrwalanie codzienności (ze szczególnym uwzględnieniem albumu „Dąbie 1918–9”)
Authors: Wierzejska Jagoda
Published: September 2024

Artykuł stanowi analizę memuarów płynnie przechodzących w dziennik – a w szczególności specyficznego rysownika o cechach diariusza i wspomnienia – autorstwa ukraińskiego malarza i grafika Leona Getza. Oba memuary stanowią bezcenne źródło wiedzy na temat losów artysty. Ponadto dają wgląd w bliską mu formę (także materialną) utrwalania codzienności. Getz w obu memuarach narrację słowną łączył z dokumentami, zdjęciami i rysunkami wykomponowanymi w tekst. Wymienione dokumenty osobiste stanowią niezbędny kontekst do przedstawienia szczególnego dzieła Getza, jakim jest album Dąbie 1918–9. Składają się nań rysunki – portrety ludzi, sceny rodzajowe i szkice zagospodarowania przestrzeni – opatrzone datami dziennymi, podpisami autora, krótkimi notatkami i/lub wpisami portretowanych osób. Zostały wykonane „na różnych przypadkowych papierach” podczas pobytu artysty w obozie internowania w Dąbiu, do którego trafił w 1919 roku. Po wyjściu z obozu Getz zebrał rysunki, nakleił je na kartony i przygotował dla nich „futerał oprawny w płótno”. Praca ta, zasadniczo rzecz ujmując, jest rysownikiem. Daty dzienne i zapiski towarzyszące rysunkom nadają jednak rysownikowi cechy dziennika i świadczą o celu, jaki przyświecał autorowi, a jakim było utrwalenie opresyjnej codzienności obozu. Opracowanie całości post factum zbliża natomiast rysownik do wycyzelowanego wspomnienia i czyni zeń dzieło sztuki. Między rysownikiem, dziennikiem a memuarem; między przypadkowym papierem a zdobną oprawą – na takim pograniczu sytuuje się charakterystyczna dla Getza forma „zapisywania” świata, także świata wojny, w tym przypadku polsko-ukraińskiej w latach 1918–1919.
„[…] człowiek bez wiadomości gorzej niż bez chleba” – epistolarna rozmowa Zofii Kossak z mężem (1939–1940)
Authors: Nowak Małgorzata , Truszkowski Artur
Published: September 2024

Artykuł stanowi omówienie Listów do Oflagu – fragmentu korespondencji Zofii Kossak kierowanej do jej męża, Zygmunta Szatkowskiego, prowadzonej na początku II wojny światowej. Analizowany materiał to archiwalny zbiór ponad stu listów przechowywanych obecnie w Szwajcarii, na który składa się korespondencja Zofii Kossak i innych członków jej rodziny do obozu jenieckiego, gdzie przebywał Szatkowski. Korespondencja stanowi dokument osobisty, rodzinny oraz społeczny, obrazujący okupacyjną rzeczywistość.
Autorzy artykułu ukazują, jaki wpływ na korespondencję Kossak i Szatkowskiego miały wojenne regulacje prawne. Dowodzą także, że listy Kossak zawierają dodatkową, oprócz dosłownej, treść ukrywaną przed cenzurą. Omówiono tematykę listów, w której na pierwszy plan wysuwa się troska o podstawowy byt uwięzionego męża, relacje z życia rodziny oraz wsparcie emocjonalne. Korespondencja obejmowała także kwestie logistyczne, jak zaopatrzenie jeńca i finanse rodziny.
Artykuł analityczny uzupełnia publikacja czternastu listów z omawianego zbioru. Jest to pierwsza odsłona korespondencji rodzinnej Zofii Kossak, która do tej pory nie była publikowana. Tekst listów został zmodernizowany pod względem interpunkcji i pisowni.
Politykier Jerzy Kłosiński ocenia Profesora Artura Hutnikiewicza
Authors: Obremski Krzysztof
Published: September 2024

Bardzo krytyczna i tylko wycinkowa recenzja książki Jerzego Kłosińskiego Mistrz – profesor Artur Hutnikiewicz. Najważniejszy zarzut: kompetencje literaturoznawcze autora pozostają co najwyżej umiarkowane; zarazem jego nieskrywane zaangażowanie polityczne sprawia, że staje się on politykierem.
Informacje o Autorach
Authors: Markuszewska Agnieszka
Published: September 2024

Informacje o Autorach.
Emptiness in a Human Soul: Simone Weil’s Anthropology
Authors: Gurczyńska-Sady Katarzyna
Published: September 2024

Pustka w duszy człowieka. Antropologia Simone Weil
Artykuł stanowi próbę wyinterpretowania, na podstawie pism Simone Weil, koncepcji ludzkiej duszy. Obraną metodą jest zestawienie uwag o charakterze ontologicznym i teologicznym, czyli tych dotyczących świata i Boga, aby na ich tle ukazać tezę mówiąca o tym, że dusza ludzka by się wyzwolić powinna stać się pusta. W związku z tym poruszone zostają klasyczne dla teologii problemy: te dotyczące bytu (jego stworzenia, istoty, przeznaczenia), te dotyczące prawdy (jej rozumienia i poznania) oraz te dotyczące dobra (rozpatrywana jest kwestia sposobu życia, które pozwala zbliżyć się do Boga). Relacyjne ujęcie człowieka – w związku z Bogiem i światem odnosi się w pierwszym rzędzie do średniowiecznej tradycji chrześcijańskiej ujmującej człowieka w odniesieniu do Boga i stworzonego przezeń świata. W ten sposób zostaje zrekonstruowana oryginalna koncepcja człowieka, który nie tylko jest stworzeniem Bożym, ale bierze udział w cyklicznym pojawianiu się i znikaniu świata.
Kontynuacja nauczania Jan Pawła II o małżeństwie i rodzinie w myśli Angela Scoli
Authors: Krupka Aneta
Published: September 2024

Angelo Scola wskazuje na istotny wpływ, jaki na papieskie nauczanie mają wcześniejsze dzieła filozoficzne i literackie Wojtyły. Kardynał wykorzystuje także teologię ciała do interpretacji synodów o rodzinie, które odbyły się za pontyfikatu papieża Franciszka. Zwraca przy tym uwagę, że współczesne magisterium powinno być interpretowane w ciągłości nauczania. Dla teologii małżeństwa i rodziny ważne jest, aby ideał przedstawiony przez Jana Paweł II został przełożony na język duszpasterskiej praktyki. Zdaniem Scoli nie da się tego zrobić, bez odnowienia integralnej wizji sakramentów oraz bez integralnego pogłębiania teologii sakramentu małżeństwa. Dopiero taka wizja może być właściwie przełożona na język wymagań prawnych i moralnych.
Building bridges. contemporary perspectives on gender, sexuality and international human rights law
Authors: Barbosa Isabel , Nardi Francesca , Reingold Rebecca , Vela Estefanía , Martínez Coral Catalina , Martínez Carmen Cecilia , Casas Lidia , Correa Sara , Novoa Tamara , Ramm Alejandra , Peralta Ramón María Susana , Salazar Londoño Ana , Turizo Vanegas José Elías , De La Cadena Silvia De La Paz , Sánchez Robinson , Davis Lisa , Bradley Danny , Arango Olaya Mónica , Parra Vera Oscar , Franco Franco F. Antonio , Cahier Laura , Céspedes-Báez Lina M. , Jaramillo Ruíz Felipe , Ospina Ana María , Benavides Vanegas Farid Samir , Ego Rebecca , Ullman Chelsea , Popa Raluca , Ellsberg Mary , Chiongson Rea Abada , Skylar Wynn Deviyani Dixit , Savoca Truzzo Florencia
Published: September 2024

Este libro incluye una colección de ensayos escritos por académicos, activistas y profesionales que reflexionan sobre avances y desafíos críticos en las áreas de género y sexualidad, y sus vínculos con el derecho internacional y los derechos humanos. Las feministas han intervenido durante mucho tiempo para promover los derechos de las mujeres, la igualdad sustancial y la erradicación de la violencia de género utilizando el derecho internacional como una herramienta importante, a través de acciones políticas y el litigio de casos ante los sistemas universales y regionales de derechos humanos y otras estrategias. La comunidad LGBTIQ+ también ha inyectado una perspectiva queer al derecho internacional. Por ello, en este volumen, una diversidad de académicos y activistas discuten cuestiones fundamentales del derecho internacional y las exploran desde una perspectiva feminista, queer o de género y de derechos humanos. Los ensayos promueven una rica discusión sobre temas críticos como los relacionados con la discriminación interseccional, la violencia contra las mujeres y las personas LGBTIQ+, los derechos sexuales y reproductivos y los desafíos para proteger los derechos humanos en situaciones de conflicto armado y contextos de crisis.
Isolated gastric Crohn's disease: a growing tendency
Authors: Nahas Rebal , Khoury Chakib , Dib Emanuel Youssef , Karam Karam , Fiani Elias
Published: September 2024

Isolated gastric Crohn's disease (IGCD) is a rare manifestation of Crohn's disease confined to the stomach, unlike its more common forms that primarily affect the ileum and colon. We report the case of a 25-year-old female presenting with a one-month history of epigastric discomfort and nausea, with no other significant gastrointestinal or systemic symptoms. Upper endoscopy revealed an aphthous ulceration on the greater curvature of the stomach, with biopsies showing non-caseating granulomas consistent with Crohn's disease. The diagnosis of IGCD was confirmed through a positive ASCA test and negative p-ANCA test, alongside the absence of ileal and colonic involvement. The patient was treated with prednisone for acute symptom management, followed by infliximab for long-term maintenance. Follow-up evaluations showed no significant relapse episodes. This case highlights the diagnostic challenges and management strategies for IGCD, emphasising the need for further research to optimise treatment protocols and improve long-term outcomes.