bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMULASI DAN UJI EFEKTIVITAS KRIM ANTIBAKTERI EKSTRAK DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP BAKTERI Staphylococcus aureus
Authors: Majid Nurul S , Yamlean Paulina V. Y. , Citraningtyas Gayatri
Published: April 2021

ABSTRACT Jackfruit leaves contain saponins, flavonoids and tannins. Which are know to have antibacterial compounds. The purpose of this study is to make cream of jackfruit leaf extract with a concentration of 5%, 10% and 15% and test the quality of preparations of  jackfruit leaf extract cream and  there is antibacterial effectiveness against Staphylococcus aureus bacteria. The method used is the ethanol extract of Jackfruit leaves by formulating it as an M/A type cream. The results showed the cream of  jackfruit leaf extract fulfilled all the physical stability tests of the cream and in the antibacterial testing of cream of Jackfruit leaf extract could inhibit the effectiveness of Staphylococcus aureus bacteria. As concluded, the Jackfruit leaf extract Conclusions obtained by jackfruit leaf extract can be formulated as a cream with a concentration of 5%, 10% and 15%, and cream preparations meet the cream quality test parameters, for testing the effectiveness of antibacterial to the biggest inhibition zone Staphylococcus aureus is 10.5 mm at 15% concentration. Keywords: Jackfruit leaves, cream antibacterial, Staphylococcus aureus. ABSTRAK Daun Nangka memiliki kandungan saponin, flavonoid dan tannin yang berperan sebagai senyawa antibakteri. Tujuan penelitian ini yaitu membuat krim ekstrak daun Nangka dengan konsentrasi 5%, 10% dan 15%, menguji mutu  dan efektivitas antibakteri krim ekstrak daun Nangka terhadap bakteri Staphylococcus aureus. Metode yang digunakan yaitu ekstrak etanol daun Nangka dengan memformulasikan sebagai krim dengan tipe M/A. Hasil penelitian menunjukkan krim ekstrak daun Nangka memenuhi semua uji kestabilan fisik krim dan dalam pengujian antibakteri krim ekstrak daun Nangka dapat menghambat efektivitas bakteri Staphylococcus aureus. Kesimpulan yang diapat ekstrak daun Nangka dapat diformulasikan sebagai krim dengan konsentrasi 5%, 10% dan 15%, dan  sediaan krim memenuhi parameter uji kualitas krim, untuk pengujian efektivitas antibakteri terhadap Staphylococcus aureus zona hambat terbesar yaitu 10,5 mm pada konsentrasi 15%. Kata kunci: Daun Nangka, krim antibakteri, Staphylococcus aureus.
ISOLASI DAN UJI ANTIBAKTERI DARI BAKTERI YANG BERASOSIASI DENGAN SPONS Phyllospongia lamellose SERTA IDENTIFIKASI SECARA BIOKIMIA
Authors: Lempoy Sela S , Lolo Widya A , Yamlean Paulina V. Y.
Published: April 2021

ABSTRACT Sponges are one source of producing bioactive components from the sea. Bacteria Symbiosis with sponges are thought to have the potential to produce bioactive compounds that have been isolated from sponges. One of the potential of bioactive compounds which have been found and developed from sponges was antibacterial. The aim of this study was to determine the antibacterial activity of bacteria associated with Phyllospongia lamellose sponges against pathogenic bacteria namely Staphylococcus aureus and Esherichia coli and then proceed with identification of biochemistry in isolates which showed the greatest inhibitory activity. Three isolates of sponges symbiont bacteria were obtained through the isolation and purification stage which were then followed by testing of antibacterial activity with paper disk diffusion method. The antibacterial test results showed the diameter of the inhibitory zone against Staphylococcus aureus, were: SL1(8.67 mm), SL2 (9.33 mm) and SL3(9.00 mm) categorized as medium. Whereas the inhibiotion zone shown on Esherichia coli bacteria is also classified as medium, were: SL1(9.67 mm), SL2 (9.00 mm) and SL3 (9.33 mm). The three isolates continued to the identification stage biochemically. Each isolation was assumed as follows: Desulfotomaculum (SL1), Brochothrix (SL2) and Sulfidobacillus (SL3). Keyword         :Phyllospongia lamellose, isolation, biochemically identification ABSTRAK Spons merupakan salah satu sumber penghasil komponen bioaktif yang berasal dari laut. Bakteri yang bersimbiosis dengan spons diduga memiliki potensi dalam menghasilkan senyawa-senyawa bioaktif yang telah diisolasi dari spons. Potensi senyawa bioaktif yang telah ditemukan dan dikembangkan dari spons salah satunya ialah sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari bakteri yang berasosiasi dengan spons Phyllospongia lamellose terhadap bakteri patogen yakni Staphylococcus aureus dan Escherichia coli dan kemudian dilanjutkan dengan identifikasi secara biokimia pada isolat yang menunjukkan daya hambat terbesar. Diperoleh 3 isolat bakteri simbion spons melalui tahap isolasi dan purifikasi yang kemudian dilanjutkan dengan pengujian aktivitas antibakteri melalui metode difusi kertas cakram. Hasil uji antibakteri menunjukkan diameter zona hambat terhadap bakteri Staphylococcus aureus yaitu: SL1(8.67 mm), SL2(9.33 mm) dan SL3 (9.00 mm) termasuk dalam kategori sedang. Sedangkan zona hambat yang ditunjukkan terhadap bakteri Escherichia coli juga tergolong kategori sedang yaitu: SL1(9.67 mm), SL2(9.00 mm) dan SL3 (9.33 mm). Ketiga isolat dilanjutkan ke tahap identifikasi secara biokimia. Masing-masing isolat diduga sebagai berikut: Desulfotomaculum (SL1), Brochothrix (SL2) dan Sulfidobacillus (SL3). Kata kunci          :Phyllospongia lamellose, isolasi, identifikasi biokimia.
UJI ANTIMIKROBA EKSTRAK DAN FRAKSI TUNIKATA Didemnum molle TERHADAP PERTUMBUHAN Escherichia coli, Staphylococcus aureus, DAN Candida albicans YANG DIKOLEKSI DI SELAT LEMBEH BITUNG
Authors: Pitoy Novia A. , Yudistira Adithya , Wewengkang Defny S.
Published: April 2021

ABSTRACTTunicate Didemnum molle is a marine biota that has bioactive components that can be used as raw material for medicines. This study aims to determine the antimicrobial activity of extracts and fractions of Didemnum molle on microbial growth of Escherichia coli, Staphylococcus aureus and Candida albicans. The sample was extracted by maceration using ethanol and fractionated using, n-hexane, chloroform and methanol. Antimicrobial activity was tested using the disc diffusion test method (Kirby and Bauer). Ethanol extract of Didemnum molle inhibited the growth of microbes of Staphylococcus aureus (8.12 mm) and Candida albicans (9.00 mm). Chloroform fraction inhibited the growth of Staphylococcus aureus (9.10 mm), Escherichia coli (10.00 mm) and Candida albicans (9.65 mm). While the methanol fraction is only able to inhibit microbial growth of Candida albicans (10.00 mm). The hexane fraction shows no activity against all test microbes. Keywords : Tunikata Didemnum molle, antimicrobial, Escherichia coli, Staphylococcus   aureus, Candida albicans.                                                                                                     ABSTRAKTunikata Didemnum molle merupakan biota laut yang memiliki komponen bioaktif yang dapat dimanfaatkan sebagai bahan baku obat-obatan. Penelitian ini bertujuan untuk mengetahui aktivitas antimikroba dari ekstrak dan fraksi tunikata Didemnum molle terhadap pertumbuhan mikroba Escherichia coli, Staphylococcus aureus dan Candida  albicans. Sampel diekstraksi dengan cara maserasi menggunakan etanol dan difraksinasi menggunakan, n-heksan, kloroform dan metanol. Aktivitas antimikroba diuji menggunakan metode disc diffusion test (Kirby dan Bauer). Ekstrak etanol Didemnum molle menghambat pertumbuhan mikroba Staphylococcus aureus (8,12 mm) dan Candida albicans (9,00 mm). Fraksi kloroform menghambat pertumbuhan mikroba Staphylococcus aureus (9,10 mm), Escherichia coli (10,00 mm) dan Candida albicans (9,65 mm). Sementara fraksi metanol hanya mampu menghambat pertumbuhan mikroba Candida albicans (10.00 mm). Fraksi heksan tidak menunjukkan aktivitas terhadap semua mikroba uji. Kata Kunci : Tunikata Didemnum molle, antimikroba, Escherichia coli, Staphylococcus aureus, Candida albicans.
UJI EFEK ANTELMINTIK EKSTRAK ETANOL DAUN PINANG YAKI (Areca vestiaria) TERHADAP CACING GELANG (Ascaris lumbricoides) SECARA IN VITRO
Authors: Roring Tirza , Simbala Herny E. I. , De Queljoe Edwin
Published: April 2021

ABSTRACT Pinang Yaki (Areca vestiaria) is an endemic species of Sulawesi palm, which has unique characteristics that have been used as medicine , to treat various. Ethanol extracts of pinang yaki leaves contains tannin compounds that can inhibit the work of enzymes, interfere with digestive metabolic processes, and damage the worm cell membrane. This study aims to determine the anthelmintic effect of ethanol extract of pinang yaki leaves obtained from the Tomohon area against roundworms (Ascaris lumbricoides). The sample was extracted by maceration method using ethanol solvent. The test used ethanol extracts f pinang yaki leaves with a concentration of 5%, 10%, and 20%, respectively. The worms were incubated at a temperature of 37ºC, and examined for 24 hours at 6 hour intervals. The number of lysis worms and paralysis was recorded every 6 hours and the data were analyzed using the Kruskal Wallis test and continued using the Mann Whitney test. The results showed an anthelmintic effect of ethanol extracts of pinang yaki leaves on roundworms (Ascaris lumbricoides) in vitro.Keywords         : Anthelmintic, Ethanol extracts of areca leaf, Areca vestiaria, Ascaris lumbricoides  ABSTRAK Pinang Yaki (Areca vestiaria) merupakan jenis palem endemik Sulawesi yang memiliki karakteristik yang unik telah dimanfaatkan sebagai obat, untuk mengobati berbagai penyakit. Ekstrak etanol daun pinang yaki mengandung senyawa tanin yang dapat menghambat kerja enzim, mengganggu proses metabolisme pencernaan, serta merusak membran sel cacing. Penelitian ini bertujuan untuk mengetahui adanya efek antelmintik dari ekstrak etanol daun pinang yaki yang diperoleh dari daerah Tomohon terhadap cacing gelang (Ascaris lumbricoides). Sampel diekstraksi dengan metode maserasi menggunakan pelarut etanol. Metode penelitian ini ialah eksperimen laboratorium dengan desain post test only control group. Pengujian menggunakan ekstrak etanol daun pinang yaki dengan konsentrasi 5%, 10%, dan 20%. Cacing diinkubasi pada suhu 37ºC, dan diteliti selama 24 jam dengan interval waktu 6 jam. Jumlah cacing lisis dan paralisis dicatat setiap 6 jam dan selanjutnya data dianalisis menggunakan uji Kruskal Wallis dan dilanjutkan menggunakan uji Man Whitney. Hasil penelitian menunjukkan adanya efek antelmintik dari ekstrak etanol daun pinang yaki terhadap cacing gelang (Ascaris lumbricoides) secara in vitro. Kata kunci      : Antelmintik, Ekstrak Etanol Daun Pinang Yaki, Areca vestiaria, Ascaris lumbricoides
AKTIVITAS ANTIMIKROBA EKSTRAK ETIL ASETAT JAMUR LAUT YANG DIISOLASI DARI ORGANISME LAUT SPONS Phylospongioa lamellosa YANG DIAMBIL DARI PERAIRAN DESA TUMBAK, KECAMATAN PUSOMAEN, KABUPATEN MINAHASA TENGGARA TERHADAP MIKROBA Staphylococcus aureus, Escherichia coli, dan Candida albicans
Authors: Tumiwa Priscila Irene , Yudistira Adithya , Wewengkang Defny S.
Published: April 2021

ABSTRACT Sponges are multi-cell marine invertebrates whose tissue and organ functions are very simple which live in coral reef ecosystems. Sponges are known to produce bioactive compounds because of their symbiotic relationships with microorganisms so that they have the potential to be developed in the field of medicine including as an antimicrobial. This study aims to determine whether the fungus associated with Phyllospongia lamellose sponge taken from the waters of, Southeast Minahasa Regency has antimicrobial activity. This research includes sampling, isolation and fungal inoculation, fermentation, extraction with acetone and then fractionated with ethyl acetate solvent,dried until it gets crude extracts and is carried out as well as antimicrobial testing against Staphylococcus aureus, Escherichia coli, and Candida albicans. Antimicrobial activity was obtained from inhibitory zones formed around the paper disk against the test microbes. From the results of the study concluded that the fungus associated with the Phyllospongia lamellose sponge has antimicrobial activity against the bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans. Keywords: Phyllospongia lamellose sponge, Antimicrobial, Stapylococcus aureu, Escherichia coli, Candida albicans. ABSTRAK Spons merupakan invertebrata laut multi sel yang fungsi jaringan dan organnya sangat sederhana yang hidup pada ekosistem terumbu karang. Spons diketahui menghasilkan senyawa bioaktif karena adanya hubungan simbiotik dengan mikro organisme sehingga berpotensi untuk dikembangkan dalam bidang pengobatan diantaranya sebagi antimikroba. Penelitian ini bertujuan untuk mengetahui apakah jamur yang berasosiasi dengan spons Phyllospongia lamellose yang diambil dari perairan Desa Tumbak, Kecamatan Posumaen, Kabupaten Minahasa Tenggara memiliki aktivitas antimikroba. Penelitian ini meliputi kegiatan pengambilan sampel spons Phyllospongia lamellose, isolasi dan inokulasi jamur yang berasosiasi dengan spons, fermentasi, ektraksi dengan aseton kemudian difraksinasi dengan pelarut etil asetat, dikeringkan hingga mendapat ekstrak kasar dan dilakukan serta pengujian antimikroba terhadap bakteri Staphylococcus aureus, Escherichia coli, dan jamur Candida albicans. Aktivitas antimikroba didapatkan dari zona hambat yang terbentuk disekitaran cakram kertas terhadap mikroba uji. Dari hasil penelitian disimpulkan bahwa jamur yang berasosiasi dengan spons Phyllospongia lamellose memiliki aktivitas antimikroba terhadap bakteri Staphylococcus aureus, Escherichia coli, dan jamur Candida albicans. Kata Kunci : Spons Phyllospongia lamellose, Antimikroba, Stapylococcus aureu, Escherichia coli, Candida albicans.
AKTIVITAS ANTIMIKROBA DARI EKSTRAK DAN FRAKSI ORGANISME LAUT SPONS Stylissa carteri YANG DIKOLEKSI DARI PERAIRAN SELAT LEMBEH KOTA BITUNG
Authors: Watupongoh Cavieta C. A. , Wewengkang Defny S. , Rotinsulu Henki
Published: April 2021

ABSTRACTSponge is a multi-cell marine biota whose tissue and organ functions are very simple. Sponges have considerable potentially in producing active compounds that can be used in the pharmaceutical world. This study aimed to determine the presence of antimicrobial activity from extracts and fractions of the Stylissa carteri Sponge on against the microbes of Staphylococcus aureus, Escherichia coli, and Candida albicans. The extraction process was carried out by maceration using ethanol solvent, and fractionation was carried out using methanol, n-hexane and chloroform solvents. Antimicrobial activity was carried out by disk diffusion agar method. The results showed that the crude ethanol extracts and methanol fractions of the Stylissa carteri sponge actively inhibited the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans microbes. Keywords: Stylissa carteri, antimicrobial, Staphylococcus aureus, Escherichia coli, Candida albicans.  ABSTRAKSpons merupakan biota laut multi sel yang fungsi jaringan dan organnya sangat sederhana. Spons memiliki potensi cukup besar dalam  menghasilkan senyawa aktif yang dapat digunakan dalam dunia farmasi. Penelitian ini bertujuan untuk menentukan adanya Aktivitas Antimikroba dari ekstrak dan fraksi Spons Stylissa carteri terhadap mikroba Staphylococcus aureus, Escherichia coli, dan Candida albicans. Dilakukan proses ekstraksi dengan cara maserasi terhadap sampel menggunakan pelarut etanol, dan dilakukan fraksinasi menggunakan pelarut metanol, n-heksan dan kloroform. Aktivitas antimikroba dilakukan dengan metode difusi agar. Hasil penelitian menunjukkan bahwa ekstrak kasar dan fraksi metanol dari spons Stylissa carteri aktif menghambat pertumbuhan mikroba Staphylococcus aureus, Escherichia coli, dan Candida albicans.  Kata Kunci : Stylissa carteri, antimikroba, Staphylococcus aureus, Escherichia coli, Candida albicans.
FORMULASI DAN EFEK ANTIBAKTERI MASKER PEEL-OFF EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphlococcous epidermidis
Authors: Daimunon Regita , Yamlean Paulina V. Y. , Jayanto Imam
Published: April 2021

ABSTRACT Kersen leaf (Muntingia calabura L.) contains flavonoids, saponins and tannins, which could inhibit bacterial activity. This study aimed to formulate, evaluate, and to test the effectiveness of antibacterial preparations for the Kersen leaf ethanol extracts mask.  This study uses the experimental method by testing the parameters of the physical evaluation requirements for the masker. Physical evaluation of preparations included organoleptic test, homogeneity test, pH test, scattering power test, dry time test, sticky test and cycling test, all tests were carried out before and after cycling test. The results of the preparation study meet the requirements of physical evaluation before the cycling test but after the cycling test is is not in accordance to the requirements for the preparation of the peel-off mask. The antibacterial test of mask peel-off ethanol extract of Kersen's leaves on Staphylococcus epidermidis bacteria produced a moderate inhibition. So it can be concluded that the ethanol extracts of Kersen leaves at a concentration of 20%.  can be formulated as a peel-off mask that is physically stable and has moderate antibacterial activity.Keywords: Kersen, Peel-off mask, Antibacterial, Staphlococcous epidermidis ABSTRAK Daun Kersen (Muntingia calabura L.) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri.  Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan masker peel-off ekstrak etanol daun Kersen. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik masker peel-off. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu sediaan mengering, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test namun setelahnya tidak sesuai dengan persyaratan sediaan masker peel-off. Penelitian uji antibakteri masker peel-off ekstrak etanol daun Kersen pada bakteri staphylococcus epidermidis menghasilkan daya hambat yang sedang. Dapat disimpulkan pada kosentrasi 20% ekstrak etanol daun Kersen dapat diformulasi sebagai sediaan masker peel-off yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang .Kata kunci : Kersen, Masker peel-off, Antibakteri, Staphlococcous  epidermidis
UJI EFEK ANTIPIRETIK EKSTRAK ETANOL DAUN MIANA(COLEUS SCUTELLARIOIDES [L]) BENTH PADA TIKUS PUTIH JANTAN GALUR WISTAR (RATTUS NORVEGICUS)
Authors: Benjamin Sri Gentari , Yudistira Adithya , Rotinsulu Henki
Published: April 2021

ABSTRACTThis study aims to determine the antipyretic effect of miana leaves extract (Coleus scutellariodes L Bent) in white male rats strain wistar. The subjects of this study were 15 white male rats, which were divided into 5 groups, namely the negative control group (1% CMC), the positive control group (Paracetamol), and the treatment group (miana leaf extracts). This type of research is a laboratory experiment, which carried out on the test animals based on a Completely Randomized Design (CRD) by testing the antipyretic effect carried out by administering the DPT-Hb vaccine. The observed response was in the form of data retrieval related to rat temperature after 2 hours of DPT-hb vaccine administration. Body temperature measurements were carried out before administering the vaccine, then successively at the 30th, 60th, 90th, and 120th minutes, respectively. The results showed miana leaf extracts at a dose of 25 mg, 50 mg and 75 mg had an antiperetic effect in white male rats but the dose 75mg provides the most effective antipyretic effect. Thus it can be concluded that the ethanol extracts of miana leaves has an antipyretic effect in white male rats, which were induced orally.  Keywords: Antipyretics, Miana Leaves, Male White Rat. ABSTRAK Penelitian ini bertujuan untuk mengetahui Efek Antipiretik Ekstrak daun Miana (Coleus scutellariodes [L] Bent) pada Tikus Putih Jantan Galur Wistar. Subjek penelitian ini ialah 15 ekor tikus putih jantan yang dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif (CMC 1%), kelompok kontrol positif (Parasetamol), dan kelompok perlakuan (ektrak daun miana).Jenis penelitian ini ialah eksperimental laboratorium yang akan dilakukan pada hewan uji berdasarkan Rancangan Acak Lengkap (RAL) dengan pengujian efek antipiretik dilakukan dengan cara memberikan vaksin DPT-Hb. Respon yang diamati yaitu berupa pengambilan data terkait suhu tikus setelah 2 jam pemberian vaksin DPT-hb. Pengukuran suhu tubuh dilakukan sebelum pemberian Vaksin, kemudian berturut-turut pada menit ke-30, 60, 90, dan 120. Hasil penelitian menunjukan ekstrak daun Miana dengan dosis 25 mg, 50 mg dan 75 mg memiliki efek antiperetik pada tikus putih jantan namun dosis 75 mg memberikan  efek antipiretik yang paling efektif. Dengan demikian dapat disimpulkan bahwa ekstrak daun miana memiliki efek antipiretik pada tikus putih jantan yang di induksi secara oral.  Kata kunci : Antipiretik, Daun Miana, Tikus Putih Jantan
PENGARUH PENAMBAHAN ASAM BENZOAT TERHADAP PERTUMBUHAN RAGI DAN KADAR ALKOHOL PADA FERMENTASI KULIT NANAS (Ananas comosus L.) LOKAL
Authors: Astuti Feni P. , Datu Olvie S. , Tallei Trina E.
Published: April 2021

ABSTRACTPineapple skin (Ananas comosus L.) has good nutritional value. Pineapple waste that has not been used will cause environmental problems, and therefore one of the utilization of pineapple waste by fermentation. The addition of benzoic acid is done so that the fermentation product is not alcoholic. The aim of this study was to evaluated the effect of addition benzoic acid on yeast growth and alcohol content on the fermentation of pineapple skin (Ananas comosus L.). Fermentation was carried out for 7 days by adding some concentrations of benzoic acid and measured total acid, alcohol content, pH, and yeast growth on media Saboroud Dextrose Agar (SDA). Results of the study showed that the added fermentation concentration of 0.05%; 0.1% and 0.2% benzoic acid have lower alcohol content and yeast amount compared with fermentation using 0% benzoic acid, so concluded there is an effect of the addition of benzoic acid on yeast growth and alcohol content. Keywords: Pineapple, Benzoic Acid, Alcohol, Yeast.   ABSTRAKKulit buah nanas (Ananas comosus L.) memiliki nilai gizi yang baik. Limbah buah nanas yang belum dimanfaatkan akan menimbulkan masalah lingkungan, maka dari itu salah satu pemanfaatan limbah buah nanas dengan cara fermentasi. Penambahan asam benzoat dilakukan agar produk fermentasi tidak bersifat alkoholik. Penelitian ini bertujuan mengevaluasi pengaruh penambahan asam benzoat terhadap kadar alkohol dan pertumbuhan ragi pada fermentasi kulit nanas (Ananas comosus L.). Fermentasi dilakukan selama 7 hari dengan menambahkan beberapa konsentrasi asam benzoat kemudian diukur total asam, kadar alkohol, pH, serta pertumbuhan ragi pada media Saboroud Dextrose Agar (SDA). Hasil penelitian menunjukan bahwa fermentasi yang ditambahkan konsentrasi 0,05%; 0,1% dan 0,2% asam benzoat memiliki kadar alkohol dan jumlah ragi yang lebih rendah dibandingkan dengan fermentasi yang menggunakan 0% asam benzoat, sehingga disimpulkan terdapat pengaruh penambahan beberapa konsentrasi asam benzoat terhadap pertumbuhan ragi dan kadar alkohol. Kata Kunci : Nanas, Asam Benzoat, Alkohol, Ragi.
FORMULASI SEDIAAN PERONA PIPI KOMBINASI EKSTRAK ETANOL UBI JALAR UNGU (Ipomoea batatas L.) DAN BUNGA KANA MERAH (Canna coccinea Mill.) DALAM BENTUK STICK
Authors: Manik Grace Dien , Edy Hosea J. , Suoth Elly J.
Published: April 2021

ABSTRACT Purple Sweet Potato (Ipomoea batatas L.) and Red Cana Flower (Canna coccinea Mill.) contain natural dyes (anthocyanins) which are used as an alternative natural dyes as well as natural antioxidants. This study aims to make and discover the physical evaluation of blusher preparations using natural dyes in a combination of Purple Sweet Potato extract and Red Cana Flower with a concentration of 15%: 15%, 15%: 20 %, 20%: 20%. This research used laboratory experimental methods. The results of the physical properties test showed that the resulting preparations gave a light purple to purplish pink color, had a distinctive odor of pafrum oleum rose, had a soft texture, all preparations had a homogeneous composition, the ph value of the preparations ranged from 6.00 – 6.45, the best polish at concentrations dye 20%: 20%, for 14 days of observation the color on all preparations did not change with light, and the most preferred preparations by researcher are those with dye concentrations of 20%: 20%. It shows that it can be concluded that a combination of ethanol extract of Purple Sweet Potato and Red Cana Flower. Can be used as a natural dye in blush preparations. Keywords:  Ipomoea batatas L., Canna coccinea Mill., Blusher. ABSTRAK  Ubi Jalar Ungu (Ipomoea batatas L.) dan Bunga Kana Merah (Canna coccinea Mill.) mengadung pewarna alami (antosianin) yang digunakan sebagai zat pewarna alami alternatif mapun sebagai antioksidan alami. Penelitian ini bertujuan untuk membuat serta mengetahui evaluasi fisik sediaan perona pipi dengan memanfaatkan pewarna alami pada kombinasi ekstrak Ubi Jalar Ungu dan Bunga Kana Merah dengan konsentrasi 15%:15%, 15%:20% dan 20%:20%. Penelitian ini menggunakan metode eksperimental laboratorium. Hasil pengujian sifat fisik menunjukan bahwa sediaan yang dihasilkan memberikan warna ungu muda hingga merah muda keunguan, bau khas parfum oleum rose, teksturnya lembut, semua sediaan memiliki susunan yang homogen, nilai pH sediaan berkisar 6,00 - 6,45, polesan terbaik pada konsentrasi zat warna 20%:20%, selama 14 hari pengamatan warna pada semua sediaan tidak mengalami perubahan terhadap cahaya, dan sediaan yang paling disukai oleh panelis adalah sediaan dengan konsentrasi zat warna 20%:20%. Dengan demikian dapat disimpulkan bahwa kombinasi ekstrak etanol Ubi Jalar Ungu dan Bungu Kana Merah dapat digunkan sebagai pewarna alami dalam sediaan perona pipi. Kata kunci: Ipomoea batatas L., Canna coccinea Mill., Perona pipi
Driven dynamics of a two-dimensional incommensurate interface
Authors: Kawaguchi Takaaki
Published: April 2021

Sliding dynamics of a two-dimensional incommensurate lattice on a substrate lattice with a periodic potential is studied using numerical simulations. This lattice system is a simplified model of nanoscale experimental devices such as the friction force microscope and the surface force apparatus. In the present system, when a misfit angle between the principal directions of lattices exists and the interatomic interaction between lattices is strong, the lattice is pinned and its structure is modulated complicatedly. Even in sliding states the effect of the modulation is highly affected, and the sliding of the lattice takes place in a certain direction which may not be parallel to the direction of the external driving force. This is due to the formation of flow channels accompanied by confining barriers in the transverse direction to the sliding motion. The directions of flow channels obviously reflect the pinned lattice structures in the stationary state. In such sliding states pinning behavior in the direction transverse to the flow channels is observed.
Polarization control of ScAlN, ZnO and PbTiO3 piezoelectric films: application to polarization-inverted multilayer bulk acoustic wave and surface acoustic wave devices
Authors: Yanagitani Takahiko , Takayanagi Shinji
Published: April 2021

Polarization-inverted multilayers are promising for application in bulk acoustic wave (BAW) resonators, BAW transformers, surface acoustic wave (SAW) devices and nonlinear optics crystals (NLOs). However, is difficult to obtain a polarization-inverted multilayer by a conventional polarization control technique using a buffer layer. Recently developed ion beam-induced polarization inversion film growth is attractive for multilayer fabrication. Low-energy ion beam irradiation (several hundred electron volts) during film growth enables the growth of polarization-inverted (0001)/(000

1

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) c-axis normal ZnO, AlN and ScAlN piezoelectric films. These structures excite a thickness extensional mode (longitudinal wave). In contrast, high-energy ion beam irradiation (300–3000 eV) induces c-axis parallel film growth which allows the fabrication of c-axis horizontal inversion ZnO and AlN multilayers. These structures are suitable for thickness shear mode (TSM) film bulk acoustic resonators (FBARs), TSM liquid sensors and out-of-plane NLOs. This review introduces the unusual polarization inversion film growth induced by ion beams and its applications. On the other hand, a (001)/(00

1

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) polarization-inverted layer can be obtained using ferroelectric films. This paper also provides the result of external electric field-induced polarization inversion of PbTiO3 epitaxial films.
Prediction of Heart Stroke using A Novel Framework – PySpark
Authors: B Chitluri Sai Harish , vamsi G gnana krishna , akhil G jaya phani , sravan J n v hari , chowdary V mounika
Published: April 2021

Heart diseases are one of the most challenging
problems faced by the Health Care sectors all over the world.
These diseases are very basic now a days. With the expanding
count of deaths because of heart illnesses, the necessity to build up
a system to foresee heart ailments precisely. The work in this
paper focuses on finding the best Machine Learning algorithm for
identification of heart diseases. Our study compares the precision
of three well known classification algorithms, Decision Tree and
Naïve Bayes, Random Forest for the prediction of heart disease by
making the use of dataset provided by Kaggle. We utilized various
characteristics which relate with this heart diseases well, to find
the better algorithm for prediction. The result of this study
indicates that the Random Forest algorithm is the most efficient
algorithm for prediction of heart disease with accuracy score of
97.17%.
Decision Support System for an Art University
Authors: Vecherskaya Svetlana E.
Published: April 2021

A prototype of an automated decision support system
for creative universities has been developed, which will allow
assessing the achievements particularly talented students and
identifying the needs in the learning process in order to help
organize the educational process in accordance with identified
capabilities. Use of a decision support system based on the
Bayesian classifier is suggested which will allow to evaluate
factors contributing to the progress in teaching students
particular techniques, and in perspective to assess the possible
resources that will be required to make changes to the learning.
The list of specific performance indicators is given. The system
should contribute to the formation of the learning plan, taking
into account the capabilities of both a group art workshop as a
whole, and special needs of an individual to develop, if necessary
an individual approach.
LINGUAL BRAKE ANALYSIS AND EVALUATION IN CHILDREN IN THE AMAZON FACULTY - IAES
Authors: Fonseca Vieira Darlemcris da , Pedroso Matos Anselmo Junio
Published: April 2021

The lingual brake is an important structure for the musculoskeletal growth of the baby's jaws, inuencing the act of sucking, speaking and feeding.
There is an alteration called ankyloglossia (Ankylos: Linked and Glossa: Tongue), dened as a congenital malformation that alters mobility and
lingual function. Brake change occurs when a portion of the tissue that should have suffered apoptosis during embryonic development remains on
the underside of the tongue, restricting its movement. The lingual brake is formed by a connective tissue rich in elastic bers, lined with nonkeratinized stratied paved epithelium, containing adipose cells, muscle bers and blood vessels. Any anatomical or functional brake deciency
can have an impact on functions based on their severity. Its diagnosis is not difcult, as it is very visible and can be done through the "Tongue Test".
Surgical removal of the brake is necessary when it causes gingival retraction, diastema, hindering orthodontic, speech therapist, prosthetic and
aesthetic treatment. It is advisable to wait for the individual's growth process, especially between 6 months and 6 years of life. The treatment
performed for this anomaly is the frenectomy, which consists in the complete removal of the brake insert. The objective of the present study was to
conduct a research that evaluated the lingual brake of children, and the need for surgical treatment at the pediatric dentistry clinic at Amazon
Faculty - IAES through a questionnaire. It was a cross-sectional, descriptive and observational study, which evaluated the lingual brake of children.
Data were analyzed quantitatively and qualitatively using the statistical data program. The software used for data analysis was Epi Info version
7.2.2.6 for windows. It was concluded that of the 50 lingual brakes evaluated, 14% presented alteration, with a preference for females. It was clear
the need for an early diagnosis, besides the need for a multidisciplinary team
DIFFERENT SURGICAL OPTIONS IN MANAGEMENT OF LOWER THIRD LEG DEFECTS
Authors: Pathak Ajay Kumar , Awasthi Pragati , Sweta Sweta , Adhikary Souvik
Published: April 2021

Background: The reconstruction of traumatic soft tissue defects in the distal third of the leg is one of the most challenging problems in lower limb
surgery. Among the most widely used techniques direct closure, skin grafting, local aps, pedicled ap and free ap are worthy of note. Usually, the
low mobility of the surrounding skin does not make a direct closure possible. Aim: Different surgical options in management of lower third leg
defects.Material and method: The study was conducted from JANUARY2018 to December 2019, in the Department of Plastic & Reconstructive
Surgery Institute of Post Graduate Medical Education and Research (IPGME&R) and SSKM Hospital, KOLKATA. Result: 70 patients admitted
to the Department of Plastic & Reconstructive Surgery and referred patients from Department of General Surgery &Orthopaedic Surgery,
IPGME&R and SSKM Hospital, KOLKATA. We found that 30(42.9%) patients were female and 40(57.1%) patients were male. The mean age
(mean± s.d.) of patients was 38.2286 ± 18.4651 years. Conclusion: Fasciocutaneous aps may represent a good alternative to the free aps in the
areas were other local reconstructive procedures are not possible
THE PREVALANCE OF PERIPHERAL ARTERIAL DISEASE IN LONG STANDING ASYMPTOMATIC SHOP-WORKERS BETWEEN THE AGE GROUP OF 35-45 YEARS USING OSCILLOMETRIC TECHNIQUE: A PILOT STUDY
Authors: Navalkar Shrineel , Ghumatkar Mayuri , Kumar Ajay
Published: April 2021

Background: Peripheral arterial disease is a type of irreversible cell injury to the tissue. Prolonged standing is associated with many health
affections related to MSK injury, psychology, mental stress and cardiovascular disease such as DVT. Assessing Ankle-brachial index by
Osscilometric technique is an easy, useful tool for screening the population for the prevalence of PAD. This study aims to identify prevalence of
PAD in long standing workers using ABI with Osscilometric technique.
Method: In this study, 20 long standing workers were selected according to the selection criteria, the participants were installed in a quiet room, or
sitting for at least 5 min before measurement. Measurement of systolic pressures of the four limbs were taken in all patients.3 cycles of
measurement (right arm, right ankle, left ankle, left arm) were repeated.
Results: In our study, prevalence was found to be 23%, out of which 15% were having mild PAD, 8% having moderate PAD. Out of 20 individuals,
14 individuals had a normal score ABI, 6 individuals were found to have lower score- all 6 having bilateral in involvement. 2 of them having
moderate and mild involvement in respective lower extremities.
Conclusion: Our study concluded that standing for long period has a considerable impact on lower limb blood circulation, and intervention can be
made to prevent the circumstances.
Recomendações aos pacientes submetidos a cirurgia bariátrica em relação à imunização contra o COVID-19
Authors: Benito Linconl Agudo Oliveira , Lima Rosana da Cruz , Karnikowski Margô Gomes de Oliveira , Silva Izabel Cristina Rodrigues da
Published: April 2021

A obesidade (CID 10: E-66) se constitui enquanto doença crônica proveniente do acúmulo de tecido adiposo, relacionada ao índice de massa corporal (IMC) igual ou superior de 30, multifatorial, e também, com interação à fatores comportamentais, culturais, genéticos, metabólicos, sociais, econômicos e políticos.1,2 Segundo dados fornecidos pela Organização Mundial da Saúde (OMS) desde o ano de 1975, o problema da obesidade e da obesidade mórbida quase que triplicou em todo o mundo e, em 2016, cerca de 1,9 bilhão de pessoas adultas, que já se encontravam na faixa etária igual ou superior a 18 anos, estariam mais propensas a serem diagnosticadas com essa enfermidade.
Cuidados de Enfermagem a um Adolescente com Necrólise Epidérmica Tóxica: Relato de Caso
Authors: Paulo Gabriela Maria Lara de , Silva Ana Caroliny da , Margarida Mykaella Cristina Araujo , Colares Carlos Matheus Pierson , Pereira Thainara Lorraine Costa e Silva , Xavier Lais Lara Silva , Melchior Lorena Morena Rosa
Published: April 2021

Objetivo: Relatar a assistência de enfermagem diante do caso de um adolescente com diagnóstico de Necrólise Epidérmica Tóxica (NET) internado em uma Unidade de Terapia Intensiva de Queimados. Método: Trata-se de um relato de caso sobre as intervenções de enfermagem realizadas em um adolescente com diagnóstico de NET, internado por um mês em 2020 na Unidade de Terapia Intensiva de Queimados de Goiás. As informações foram coletadas do prontuário do paciente. Resultados: Apresentamos práticas clínicas para auxiliar no manejo de pacientes com NET. O caso apresentado teve um desfecho positivo. Conclusão: Os cuidados de enfermagem são essenciais para o prognóstico positivo do paciente. Nesse caso, a enfermagem atuava principalmente no cuidado de feridas, administração de medicamentos, laserterapia e vigilância para prevenção de infecções.
Descritores: Necrólise Epidérmica Tóxica; NET; Cuidados de enfermagem; Queimadura.
Double-View Matching Network for Few-Shot Learning to Classify Covid-19 in X-ray images
Authors: Szűcs Gábor , Németh Marcell
Published: April 2021

The research topic presented in this paper belongs to small training data problem in machine learning (especially in deep learning), it intends to help the work of those working in medicine by analyzing pathological X-ray recordings, using only very few images. This scenario is a particularly hot issue nowadays: how could a new disease for which only limited data are available be diagnosed using features of previous diseases? In this problem, so-called few-shot learning, the difficulty of the classification task is to learn the unique feature characteristics associated with the classes. Although there are solutions, but if the images come from different views, they will not handle these views well. We proposed an improved method, so-called Double-View Matching Network (DVMN based on the deep neural network), which solves the few-shot learning problem as well as the different views of the pathological recordings in the images. The main contribution of this is the convolutional neural network for feature extraction and handling the multi-view in image representation. Our method was tested in the classification of images showing unknown COVID-19 symptoms in an environment designed for learning a few samples, with prior meta-learning on images of other diseases only. The results show that DVMN reaches better accuracy on multi-view dataset than simple Matching Network without multi-view handling.
Segmentation of MRI images to detect multiple sclerosis using non-parametric, non-uniform intensity normalization and support vector machine methods
Authors: Moghadasi Mohammad , Fazekas Gabor
Published: April 2021

Multiple sclerosis (MS) is an inflammatory, chronic, persistent, and destructive disease of the central nervous system whose cause is not yet known but can most likely be the result of a series of unknown environmental factors reacting with sensitive genes. MRI is a method of neuroimaging studies that results in better image contrast in soft tissue. Due to the unknown cause of MS and the lack of definitive treatment, early diagnosis of this disease is important. MRI image segmentation is used to identify MS plaques. MRI images have an image error that is often called non-uniform light intensity. There are several ways to correct non-uniform images. One of these methods is Nonparametric Non-uniform intensity Normalization (N3). This method sharpens the histogram. The aim of this study is to reduce the effect of bias field on the MRI image using N3 algorithm and pixels of MRI images clustered by k-means algorithm. The dimensionality of the data is reduced by Principal Component Analysis (PCA) algorithm and then the segmentation is done by Support Vector Machine (SVM) algorithm. Results show that using the proposed system could diagnose multiple sclerosis with an average accuracy of 93.28%.
JURIDICAL REVIEW HATE SPEECH Law No. 11 YEAR 2008 JUNCTO Law No. 19 OF 2016 CONCERNING ELECTRONIC INFORMATION AND TRANSACTIONS IN PROVIDING COMMUNICATION ETHICS EDUCATION IN SOCIAL MEDIA
Authors: Ida Ayu Putu Anggie Sinthiya
Published: April 2021

Social media is an online media, which makes it easy for us to communicate openly; social media is able to shift conventional mass media in spreading the news. Through social media everyone gets an expression space that is free and easy to communicate, free to express, criticize and share on social media. But in its journey social media provides a space of freedom that transcends boundaries and strikes norms and ethics. Now the easier it is for someone to do hate speech in the form of provocation, incitement, or insult to other individuals or groups in terms of various aspects such as race, color, ethnicity, gender, disability to sexual orientation, citizenship and religion on social media. The legal rules regarding hate speech are regulated in Article 310 and 311 of the Criminal Code and Law Number 40 of 2008 Law Number 11 of 2008. Building good ethics on social media is the rule of law that social media users can know and understand the limitations in communicating on social media so as to create good, polite, responsible and civilized communication ethics
REGULATION OF LAND OWNERSHIP FOR FOREIGN CITIZENS IN INDONESIA FROM AGRARIAN LAW PERSPECTIVE
Authors: Yanto Nur Hairul Hari , Nasarudin Muhammad
Published: April 2021

In the agrarian system, Article 21 paragraph 1 of the Basic Agrarian Law states that only Indonesian citizens have property rights. One of the examples of ownership rights is the right to land ownership or those that may have a relationship with the earth and space without differentiating between men and women as well as fellow Indonesian citizens, both native and descendants.
THE REVITALIZATION OF THE INDONESIAN LEGAL SYSTEM IN THE ORDER OF REALIZING THE IDEAL STATE LAW
Authors: Fauzia Ana , Hamdani Fathul , Octavia Deva
Published: April 2021

It can be called that the dynamics of national and state life in Indonesia are increasingly being tested by the same problem. For example, an outbreak of judicial corruption from the time to time, which was never ending. Law enforcers who are echoed as honorable professions, but on the other hand, these are exacerbated by the corrupt behavior of those professions. The sale and purchase of a case is no longer viewed as taboo, indeed it just looks like proper. Which means, it is a kind of a sign that the various legal regulations that normatively regulate the entire judicial process are ultimately unable to overcome the judicial corruption. The main objective of this research focuses on analysis related to efforts to revitalize the legal system in order to create an ideal rule of law as stated by Lawrance Friedman in his book namely "The Legal System: A Social Science Perspective". In this research, the method used is normative juridical using statutory, conceptual and historical approaches. The results of the research present an idea which is divided into three according to the three elements in the formation of a rule of law according to Lawrance Friedman, namely legal substance, legal structure, and legal culture. With regard to legal substance, the author provides the idea of a judicial preview as a method of validating the constitutionality of laws. Then related to the legal structure, the author provides ideas related to efforts to build morality and professionalism of law enforcement officials. Meanwhile, in terms of legal culture, the author provides ideas related to efforts to build a legal culture in society that is aware of the law and the constitution.
PENGEMBANGAN MODUL PEMBELAJARAN TEMATIK PJOKTEMA DIRIKU PADA PESERTA DIDIK KELAS 1 SD DI KECAMATAN BULELENG
Authors: Komang Agus Indrayasa  , I Putu Panca Adi  , Ni Putu Dwi Sucita Dartini
Published: April 2021

Penelitian ini bertujuan untuk mengembangkan modul pembembelajaran tematik PJOK tema diriku pada peserta didik kelas 1 SD di Kecamatan Buleleng. Jenis penelitian ini adalah penelitian pengembangan. Prosedur pengembangan modul pembelajaran tematik PJOK menggunakan model Borg & Gall hanya sampai tahap 5 yaitu tahap penelitian dan pengumpulan informasi, tahap perencanaan, tahap, mengembangkan bentuk pendahuluan produk, tahap uji lapangan persiapan, dan tahap revisi produk utama. Langkah validasi modul pembelajaran tematik PJOK mengadopsi  model Borg & Gall yaitu: uji lapangan persiapan dan peneliti menambahkan uji ahli isi dan uji ahli media agar penelitian lebih signifikan. Teknik analisis data yang digunakan yaitu deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa validasi modul pembelajaran PJOK ditinjau dari aspek isi oleh ahli isi adalah sangat baik dengan presentase 91,76%. Ahli media berada pada kualifikasi baik dengan presentase 83,33%. Hasil uji lapangan persiapan dari peserta didik memperoleh presentase 96,84% dan guru PJOK memperoleh presentase 96,85% berada pada pada kualifikasi sangat baik. Berdasarkan hasil penelitian disimpulkan bahwa modul pembelajaran tematik PJOK tema diriku pada kelas 1 SD di Kecamatan Buleleng layak digunakan ditinjau dari uji ahli isi, uji ahli media dan uji lapangan persiapan. Penelitian ini diharapkan dapat dieksperimenkan untuk mengetahui efektivitas dari modul pembelajaran tematik PJOK.
PENGARUH PEMBERIAN REINFORCEMENT DAN LATIHAN MENTAL IMAGERY TERHADAP HASIL BELAJAR ROLL DEPAN DI KELAS V SDN BUNAJIH 1 LABANG MADURA
Authors: Ahmat Sainuddin  , Harwanto  , Abd Cholid
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian reinforcement dan latihan mental Imagery terhadap hasil belajar roll depan pada siswa kelas V SDN Bunajih 1 Labang Madura. Subyek dalam penelitian ini yaitu dilakukan pada kelas V yang berjumlah 18 siswa. Selanjutnya dibagi menjadi dua kelompok dengan cara ordinal pairing. Kelompok 1 sebanyak 9 siswa mendapat perlakuan pemberian reinforcement dan latihan mental Imagery Kelompok 2 sebanyak 9 siswa mendapat perlakuan pemberian reinforcement pada siswa kelas V di SDN Bunajih 1 Labang Madura. Hasil dari penelitian ini menunjukkan bahwa terdapat pengaruh pemberian reinforcement terhadap keterampilan roll depan pada siswa kelas V SDN Bunajih 1 Labang Madura yang dibuktikan sebagai berikut thitung > ttabel atau nilai thitung 3,796 > nilai ttabel 1,860 atau 0,005 < 0,05. Untuk pengaruh latihan mental imagery terhadap keterampilan roll depan pada siswa kelas V SDN Bunajih 1 Labang Madura yaitu thitung > ttabel atau nilai thitung 1,915 > nilai ttabel 1,860 atau 0,042 < 0,05, maka ada pengeruh latihan mental imagery terhadap keterampilan roll. Pada perbedaan pemberian reinforcement dan latihan mental Imagery terhadap hasil belajar roll depan yaitu thitung > ttabel atau nilai thitung 2,195 > nilai ttabel 2,119 atau 0,043 < 0,05 maka, ada perbedaan pemberian reinforcement dan latihan mental Imagery terhadap hasil belajar roll.