bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer
Authors: Wu Jinfeng , Wei Yongbao , Li Tao , Lin Le , Yang Zesong , Ye Liefu
Published: March 2022

Introduction: DNA methylation regulates gene transcriptional functions in the pathogenesis of malignant diseases. In prostate cancer, several tumor suppressors are known to be tumor specifically methylated. Methods: In this study, 450K methylation data and mRNA expression data were accessed from The Cancer Genome Atlas-Prostate Adenocarcinoma database and analyzed bioinformatically. Methylation-specific PCR was used to examine the methylation condition in AOX1 promoter. qRT-PCR was applied to measure the mRNA expression of AOX1. Western blot was employed to detect the expressions of AOX1 and the EMT associated proteins. Transwell and scratch healing assays were used to examine the invasive and migratory abilities of the prostate cancer cells respectively. Results: AOX1 was lowly expressed and hypermethylated in the prostate cancer tissues and cells. Also, AOX1 was downregulated at protein level in prostate cancer cells. Knocking down AOX1 could promote cell migration and invasion in the prostate cancer cells. By using a DNA methylation inhibitor, 5-AzadC was found to promote the expression of AOX1 and reverse the promoting effects of short interfering RNA against AOX1 on cell migration and invasion. Conclusion: This study suggested that DNA methylation and low AOX1 level might be biomarkers for prostate cancer.
Implementation of Empowerment Strategy Model for Urban Poor Based on Market Needs at The Public Vocational Training Center (BBPLK) Semarang
Authors: Ilyas Ilyas , Mulyono Sungkowo Edy , Malik Abdul , Larasati Namira Putri , Loretha All Fine
Published: March 2022

During Covid 19 pandemic, poverty is tremendously raising and expanding across the country, worsened the economic sector in almost every region in Indonesia, including in Semarang, Central Java. According to the number of residents living in Semarang, 79,058 people experienced an economic weakening in 2021. Based on the problem above, it can be concluded that there is a need for a community empowerment strategy model that is appropriate to market needs. This study reveals the implementation of a strategy model for empowering the urban poor based on market needs in the non-formal education carried out by BBPLK Semarang. This study uses a qualitative approach. The subjects of the research were 5 trainees and instructors. The technique of data collection was done by interview, observation, and documentation. To test the validity of the data, this study used technical triangulation. Data were analyzed using descriptive qualitative. This process put 3 activities, namely, (1) data reduction, (2) data presentation, and (3) drawing conclusions or verification. The community empowerment model implemented at BBPLK uses a strategy model for empowering the urban poor based on market needs. The stages of community empowerment are carried out through the awareness stage, the skill transformation stage, and the intellectual and innovative ability improvement stage. A common obstacle that occurs in BBPLK Semarang is the lack of instructors. BBPLK Semarang is still not being able to hold their instructors, so they need help from other parties such as a Private vocational training center in Semarang. Moreover, the most influential factor is the intention of the training participants themselves and the people who are reluctant to follow the training at BBPLK Semarang.
Twenty-Four Month Results of Tack-Optimized Balloon Angioplasty Using the Tack Endovascular System in Below-the-Knee Arteries
Authors: Adams George L. , Lichtenberg Michael , Wissgott Christian , Schmidt Andrej , Tarra Trisha , Matricardi Shannon , Geraghty Patrick J.
Published: March 2022

Purpose:

To report 24 month safety and efficacy of the Tack Endovascular System for treatment of post-percutaneous transluminal angioplasty (PTA) infrapopliteal dissections in patients with critical limb-threatening ischemia (CLTI).

Materials and Methods:

The Tack-Optimized Balloon Angioplasty (TOBA) II below-the-knee (BTK) study was a prospective, multicenter, single-arm evaluation of the Tack Endovascular system for post-PTA infrapopliteal dissection repair. Patients with Rutherford Clinical Category (RC) 3 to 5 and a post-PTA dissection(s) of the BTK arteries were enrolled. The 30 day primary safety endpoint was a composite of major adverse limb events (MALE) and all-cause perioperative death (POD). The primary effectiveness endpoint was a composite of MALE at 6 months and 30 day POD. Outcomes were assessed as observational endpoints at 24 months.

Results:

Tack-Optimized Balloon Angioplasty II BTK enrolled 233 patients; all patients had a post-PTA dissection(s) and received ≥1 Tack implant (range, 1–16). Mean age was 74.4±10.0 years and 67.4% were men. Most patients had CLTI (RC 3: 16.3%; RC 4/5: 83.7%). Mean target lesion length was 80±49 mm. Moderate to severe calcium was present in 89 (35.8%) lesions and total occlusions were present in 118 (47.6%) lesions. Kaplan-Meier freedom from MALE at 24 months + POD at 30 days was 92.2% and 24 month freedom from clinically-driven target lesions revascularization was 73.6%. Kaplan-Meier target limb salvage was 95.7% and amputation-free survival was 75.4%. Improvements in functional status and quality of life were observed through 24 months.

Conclusion:

The TOBA II BTK study demonstrated sustained safety and efficacy through 24 months in patients treated for post-PTA dissection(s) of BTK lesions.

Clinical Trial Registration:

ClinicalTrials.gov identifier NCT02942966.
Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation
Authors: Valko Luca , Baglyas Szabolcs , Podmaniczky Eszter , Prohaszka Zoltan , Gal Janos , Lorx Andras
Published: March 2022

Background

With the growing practice of home mechanical ventilation, there is a need to identify biological markers for adequate follow-up. Red cell distribution width (RDW) is a promising candidate because it is convenient, objective and may reflect treatment effect over a long period of time. The aim of this study was to explore the possible role of RDW as a marker for home mechanical ventilation in real-life, unselected chronic respiratory patient populations.

Methods

First, we identified characteristic RDW values for mixed case, unselected chronic respiratory failure and home mechanical ventilated patients through retrospective review within our institutional database. Next, we conducted a prospective observational study to identify RDW changes during the first six months of optimized home mechanical ventilation treatment. Adult patients starting home mechanical ventilation were included. Factors affecting RDW change during the first 6 months of treatment were analysed.

Results

RDW was elevated in both chronic respiratory failure and home mechanical ventilation patients compared to healthy individuals in the retrospective review. In the prospective study of 70 patients, we found that 55.4% of patients starting home mechanical ventilation have abnormal RDW values which are reduced from 14.7 (IQR = 13.2–16.2)% to 13.5 (IQR = 13.1–14.6)% during the first 6 months of HMV treatment (p < 0.001). RDW improvement correlates with improvement in self-reported health-related quality of life and sleepiness scale scores, as well as physical functional status during the same time frame. RDW proved to be a comparable marker to other parameters traditionally used to evaluate treatment efficacy.

Conclusions

RDW is elevated in chronic respiratory failure patients and is significantly reduced in the first six months of optimized home mechanical ventilation. Although further research is needed to verify if RDW change reflects outcome and how comorbidities influence RDW values, our results suggest that RDW is a promising marker of home mechanical ventilation efficacy.

Trial registration This study was approved by and registered at the ethics committee of Semmelweis University (TUKEB 250/2017 and TUKEB 250-1/2017, 20th of December 2017 and 1st of October 2019).
Genetic differentiation of grain, fodder and pod vegetable type cowpeas (Vigna unguiculata L.) identified through single nucleotide polymorphisms from genotyping-by-sequencing
Authors: Wu Xingbo , Cortés Andrés J. , Blair Matthew W.
Published: March 2022

The species Vigna unguiculata L. (Walp), commonly known as cowpea, is a multi-purpose legume that has been selected into three subspecies that are divided into grain, fodder and pod (yardlong bean) types. However, genetic bases for distinctions are not well understood. The purpose of this study was to apply genotyping-by-sequencing (GBS) and current reference genome for V. unguiculata to distinguish three subspecies and identify signatures of divergence. The collection of 130 accessions included 128 cultivated from: 1) ssp. cylindrica, fodder type; 2) ssp. sesquipedalis, pod vegetable type; and 3) ssp. unguiculata, grain type. Two wilds genotypes from spp. dekindtiana and spp. pubescens, were used to anchor phylogeny. A total of 11,083 highly informative single nucleotide polymorphisms (SNPs) were discovered. Wild accessions showed distinct genetic fingerprints and were separated from cultivated subspecies. Principal component analysis showed closer relationship between ssp. unguiculata and ssp. cylindrica compared to ssp. sesquipedalis. Relative differentiation of cultivated subspecies (with Fixation Index, FST) indicated the existence of discrete signatures of selection. This work clarifies the population structure, phylogeny, and domestication of cultivated cowpeas. Furthermore, significant genetic differences between grain and pod vegetable types can provide valuable information for future breeding in three cowpea groups.
The effect of Aloe vera ethanolic extract in preventing ischemic-reperfusion injury during long bone fracture healing after tourniquet application: An animal study
Authors: Huwae Thomas Erwin Christian Junus , Hidayat Mohamad , Sujuti Hidayat , Ratnawati Retty
Published: March 2022

Background: Tourniquet is a common instrument used in Orthopedics field to reduce blood loss, providing a better operating field. One of the deleterious effects of tourniquet is ischemic-reperfusion injury, which occurs after deflation of the tourniquet. One of the possible ways to mitigate ischemic-reperfusion injury is by administrating antioxidants to reduce oxidative stress. Natural ingredients like Aloe vera are well known for its antioxidant and anti-inflammatory activities. This experimental study was conducted by fracturing the tibia of male Wistar strain rats (Rattus norvegicus) and administering Aloe vera gel orally as antioxidant.

Method: A total of 18 rats were used in this study, divided into 6 groups. The first group was the control group, that included rats with fractured tibia not receiving torniquet and aloe vera treatment. The second and third groups were rats with fracture, who received torniquet application for one hour and two hours respectively without aloe vera treatment. The rest were the treatment groups, the rats with factures were given different dosages of Aloe vera extract: 40 mg/kg bodyweight (BW), 60 mg/kg BW, and 80 mg/kg BW. Three hours after administration, the tourniquet was inflated for two hours, followed by its deflation. The tibia was harvested to examine levels of superoxide dismutase (SOD), Malondialdehyde (MDA), and Bone morphogenetic protein 7 (BMP-7), and callus diameter, and osteoblast numbers were evaluated.

Result: Administration of Aloe vera extract reduced the oxidative stress parameters (SOD and MDA). Tourniquet application decreased the osteoblast cell count and callus diameter, and administration of Aloe vera extract increased both variables close to the control value (p<0.05).

Conclusion: The result of this study suggests that Aloe vera extract could be used to ameliorate ischemic-reperfusion injury.
Sedentary behaviour levels in adults with an intellectual disability: a systematic review and meta-analysis
Authors: Lynch Louise , McCarron Mary , McCallion Philip , Burke Eilish
Published: March 2022

Background: Sedentary behaviour (SB), which is characterised by low levels of energy expenditure, has been linked to increased cardio-metabolic risks, obesity and mortality, as well as cancer risk. No firm guidelines are established on safe levels of SB. Adults with an intellectual disability (ID) have poorer health than their counterparts in the general population with higher rates of multi-morbidity, inactivity, and obesity. The reasons for this health disparity are unclear however it is known that SB and overall inactivity contribute to poorer health. There is no clear picture of the levels of SB among individuals with ID therefore SB levels in this vulnerable population need to be examined. The aim of this systematic review is to investigate the prevalence of sedentary behaviour in adults with an ID.  

Methods: The PRISMA-P framework was applied to identify high quality articles. An extensive search was carried out in four databases and grey literature sources . In total, 1,972 articles were retrieved of which 48 articles went forward for full review after duplicate removal and screening by title and abstract. The National Institute of Health’s quality assessment tools were used to assess article quality. Two reviewers independently assessed each article. An excel spreadsheet was created to guide the data extraction process. The final review included 25 articles. A meta-analysis was completed using REVMAN.  

Results: Different SB assessment types were identified in studies. These included steps, time, questionnaires, and screen time. Studies were heterogeneous. Observed daily steps per individual ranged from 44 to above 30,000, with an average of approximately 6,500 steps. Mean daily time spent in SBs was more than 60% of available time, with observed screen time of more than 3 hours. 

Conclusion: There is a high prevalence of SB in adults with an intellectual disability. 

 [Registration no: Index CRD42020177225].
Research and practice in IS: insights from medicine that might contribute to overcoming the relevance deficit in the IS domain
Authors: Carvalho João Álvaro
Published: March 2022

During the ICIS 2018 conference, in San Francisco, two interesting panels addressed themes related to the recurrent debate within the IS domain about the relevance of IS research. One panel - Seeking Public Intellectuals in the Information Systems Discipline: Towards an Impact and Engagement Agenda - discussed the influence (or lack of) of the IS research community on public policies and on public opinion in what concerns problems that affect the society. The other panel - the Senior Scholar Panel - focused on the relationship between IS research and IS professional practice. The perception, by IS academics, that IS research is of little relevance for IS practitioners was addressed once more. These are two different dimensions of the relevance of IS research. Both are important to a pivotal domain in the modern society that creates scholarly knowledge crucial to understanding, influencing and leading the transformations that society is undergoing. Those dimensions are also critical if IS seeks to become a “vibrant, socially relevant and influential” domain as recently mentioned by Hassam and Mathiassen [1]. This article focuses on the relationship between IS research and IS professional practice. I share the view of those that consider that the IS domain encompasses both, an academic facet and a practical facet. The two facets are interdependent and demand forms of collaboration between academics and practitioners that are only perceptible within an overarching view of scientific knowledge and of its production and use. This article aims at proposing such a view. A main feature of the proposed view is that it involves distinguishing among different types of scientific knowledge and different modes of doing research. In particular, it involves emphasizing a form of research that is overlooked in IS - clinical research. Insights from the medicine domain are used to illustrate the place of clinical research and its role in connecting researchers and practitioners.
A comparison of project control standards based on network analysis
Authors: Perrier Nathalie , Benbrahim Salah-Eddine , Pellerin Robert
Published: March 2022

Project control is a crucial function in project management. Over the years, several best practice standards have been developed to assist project managers in improving project control. The objective of this paper is to compare three prominent best practice models of PMBOK, PRINCE2, and the AACE framework with respect to the core processes of project control. Network analysis is used to achieve this objective. The results show that influential and linkage processes, such as Control quality, Review the stage status, Forecasting, and Change management have the most significant impacts on the complexity of the project control function. This work has the potential to help rethink the project control function by creating a more global view of the most central and critical processes for project control, from which enhancement in the ability to control the project can be drawn.
Rapidly Evolving Technologies and Startup Exits
Authors: Bowen Donald E. , Frésard Laurent , Hoberg Gerard
Published: March 2022

This paper examines startups’ positioning within technological cycles. We use patent text to measure whether innovation pertains to a technological area that is rapidly evolving or stable. We show that innovation in rapidly evolving areas (i.e., early in the cycle) substitute for existing technologies, whereas innovation in stable areas (i.e., later in the cycle) complement them. Our new measure is distinct from existing characterizations of innovation and is economically important. We find that startups in rapidly evolving areas tend to exit via initial public offering, thus remaining independent, consistent with technological substitution. In contrast, startups in stable areas tend to sell out, consistent with technological complementarity and synergies.

This paper was accepted by Gustavo Manso, finance.

Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4362 .
First year pre-registration nursing student perceptions of community nursing roles: a thematic analysis
Authors: Lavery Joanna , Henshall Carmel
Published: March 2022

Nursing is the largest qualified professional workforce in the UK, with TV programmes, films, books and other media sources frequently informing the general public's views of nursing roles. This study examines first year pre-registration nursing students' perceptions of community nursing roles, using a qualitative design and questionnaire. Participants included pre-registration nursing students from a university in north west England: a mean of 240 and 68.5% across all questions. Of those invited, 267 were adult nursing students; 53 were mental health nursing students; and 30 were child nursing students. Data were collected using an online questionnaire across two groups and analysed thematically. Four questions were considered relating to students' knowledge of community nursing. Results uncovered knowledge gaps, and community roles were perceived to be less dynamic than secondary care roles, correlating to clinical tasks and popularised media sources. Results provided insight into student nurse perceptions, offering an understanding from which to construct a more inclusive, community-focused nursing curriculum.
Incoherent broadband cavity-enhanced absorption spectroscopy for sensitive measurement of nutrients and microalgae
Authors: Zhang Haodong , Luo Jing , Hou Saimei , Xu Zhanpeng , Evans Julian , He Sailing
Published: March 2022

Incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS) can achieve sensitive measurements at trace concentrations for liquid phase marine samples. The IBBCEAS system consists of a cavity-enhancement module (CEM) and a transmission hyperspectral module (THM). The CEM has cavity-enhancement factors up to 78 at 550 nm. Measurements were obtained over a wide wavelength range (420–640 nm) with a halogen lamp, and the optical cavity was formed by two concave highly reflective mirrors (

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at 550 nm corresponds to a limit of detection for nutrients of 780 pM. The spectral resolution of the THM is 3 nm in the wavelength range of 400 to 750 nm. We performed the IBBCEAS measurements for biological and chemical substances, including nutrients, microalgae, and Cy5 dye. The concentrations of nutrients in a deionized water environment and artificial seawater environment were measured at nanomolar levels; the concentration of microalgae phaeocystis was detected with

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, and fluorescence substances such as Cy5 dye could be measured at 0.03 mg/L. Experimental results show that the IBBCEAS system has the capability for sensitive measurements of biological and chemical substances and has strong potential for in situ ecological marine environmental monitoring function.
Multifaceted anapole: from physics to applications [Invited]
Authors: Masoudian Saadabad Reza , Huang Lujun , Evlyukhin Andrey B. , Miroshnichenko Andrey E.
Published: March 2022

The optical anapole state resulting from interference of the electric and toroidal moments is of much interest due to its nonradiating nature. Interference of optical modes supported by a diverse range of Mie-resonant structures has found many applications, such as in biosensors and optical communication. This review provides an overview of the recent progress of anapole states in photonics. After a brief historical background, a complete mathematical description is presented. It allows one to clearly demonstrate and identify the existence of anapole states and highlight their fundamental properties. Then, we focus on the excitation of anapoles in photonics and discuss the relation to other states, such as bound states in the continuum. Finally, we discuss a series of advances that uncover the anapole potential in various applications, from nonlinear photonics and lasing to optical communication and sensing.
Ribavirin for treating Lassa fever: A systematic review of pre-clinical studies and implications for human dosing
Authors: Salam Alex P. , Duvignaud Alexandre , Jaspard Marie , Malvy Denis , Carroll Miles , Tarning Joel , Olliaro Piero L. , Horby Peter W.
Published: March 2022

Ribavirin is currently the standard of care for treating Lassa fever. However, the human clinical trial data supporting its use suffer from several serious flaws that render the results and conclusions unreliable. We performed a systematic review of available pre-clinical data and human pharmacokinetic data on ribavirin in Lassa. In in-vitro studies, the EC50 of ribavirin ranged from 0.6 μg/ml to 21.72 μg/ml and the EC90 ranged from 1.5 μg/ml to 29 μg/ml. The mean EC50 was 7 μg/ml and the mean EC90 was 15 μg/ml. Human PK data in patients with Lassa fever was sparse and did not allow for estimation of concentration profiles or pharmacokinetic parameters. Pharmacokinetic modelling based on healthy human data suggests that the concentration profiles of current ribavirin regimes only exceed the mean EC50 for less than 20% of the time and the mean EC90 for less than 10% of the time, raising the possibility that the current ribavirin regimens in clinical use are unlikely to reliably achieve serum concentrations required to inhibit Lassa virus replication. The results of this review highlight serious issues with the evidence, which, by today standards, would be unlikely to support the transition of ribavirin from pre-clinical studies to human clinical trials. Additional pre-clinical studies are needed before embarking on expensive and challenging clinical trials of ribavirin in Lassa fever.
Reduced trolling on Russian holidays and daily US Presidential election odds
Authors: Almond Douglas , Du Xinming , Vogel Alana
Published: March 2022

Russian trolls generally supported the Trump campaign and were particularly active on Twitter 2015-2017. We find that trolling fell 35% on Russian holidays and to a lesser extent, when temperatures were cold in St. Petersburg. Exogenous variation in trolling by day allows us to considerindirectly-affected political behaviors in the US—outcomes that are less traceable via tweet sharing but potentially more important to policymakers than the direct dissemination previously studied. As a case in point, we describe reduced form evidence that Russian holidays affected daily trading prices in 2016 election betting markets. This response is consistent with successful Russian interference in support of Trump.
Distillation of Sound: Dub and the Creation of Culture
Authors: Abbey Eric
Published: March 2022

Distillation of Sound traces the beginnings of dub music in Jamaica and how the culture is distilled throughout the world. It focuses on the analysis of some of the most famous full-length albums of dub music and how the engineers, producers and musicians created a new sound that changed the way that people heard music.
Polymorphism of leptin gene (single nucleotide polymorphisms c.73T>C) and its association with body weight and body measurements in Madura cattle
Authors: Kuswati Kuswati , Furqon Ahmad , Septian Wike Andre , Susilawati Trinil
Published: March 2022

Background and Aim: Madura cattle is local cattle in Indonesia. This cattle hasphenotypic variations in growth traits. This study aimed to identify leptin (LEP) gene polymorphism exon 2 associated with body measurements in Madura cattle.

Materials and Methods: We recorded body weight (BW) and body measurements of 51 Madura cattle aged 1-4 years in Waru District, Madura. The LEP gene genotyping was conducted using the polymerase chain reaction-restricted fragment length polymorphism method with AciI restriction enzyme.

Results: A 267 bp DNA fragment of the LEP gene was successfully amplified using a pair of primers. This study revealed three genotypes (TT, TC, and CC) and two alleles (T and C). The frequencies of TT, TC, and CC genotypes were 0.275, 0.45, and 0.275, respectively, whereas the frequencies of T and C alleles were 0.500 and 0.500, respectively. The c.73T>C mutation was significantly associated with BW, body length (BL), and chest girth (CG) (p<0.05). Among all genotypes, the TC had the highest BW, BL, and CG.

Conclusion: Conclusively, LEP gene polymorphism (c.73T>C) exon 2 was polymorphic and associated with body measurements, especially BW, BL, and CG.
Views of Piano Teachers Regarding the Piano Education Process in Amateur Music Education Institutions
Authors: Karan Ezgi , Yokus Hamit
Published: March 2022

This research aims to evaluate the piano education process in private education institutions in Amateur Music Education that provide private music education in line with the opinions of piano teachers. The research study group consists of piano teachers working in the institutions affiliated to the Ministry of National Education in the province of Antalya, Muratpasa, in the Fall Semester of the 2020-2021 Academic Year. The research is a case study. The research data were obtained with the semi-structured interview form created by the researchers and analyzed descriptively. As a result of the research, it was found that piano teachers usually work with preschool and elementary school students, especially with beginners and middle school students. Some piano teachers work with students preparing for conservatories, art high schools and special examinations of pedagogical faculties. Research has shown that the most important expectations of piano lessons are primarily from parents. It has been determined that piano teachers generally adopt a "middle-do" position-based education approach, and they prefer the show-and-make method within the framework of teaching method. In addition to these, they used more than one method together instead of a single method in their education processes; in the selection of repertoire, they take into account the expectations and orientations of the students; It was determined that the majority of the teachers did not have sufficient knowledge about learning strategies, they did not use learning strategies consciously in the education process, and they rewarded the students more in order to increase their motivation.
Crisis of the Early Modern Period, Caravaggism, and the Rise of Gallery Painting
Authors: Dedić Nikola
Published: March 2022

In this essay, the emergence of Caravaggist naturalism has been analyzed at the intersection of two historical configurations. The first was a macro-process, an epochal crisis that the Reformation brought with it. The Reformation turn caused a comprehensive crisis of legitimacy that manifested itself in all spheres of life in Western culture: from religion to politics and to the status of images. The most important element of this early modern paradigm was the gradual formation of a new episteme (or system of knowledge organization) that can be defined as postclassical or modern. The classical episteme implied a fixed, stable, and static relationship between images, i.e. phenomena and words, i.e. discourse. The modern episteme was the moment of disintegration of this static worldview, when the organic connection between things and words, the visible and the sayable, came into danger and even a complete discrepancy. The second process took place on the micro-level and was related to the social structuring of Rome at the end of the 16th century, when there was an obvious gap between the “official” policy of the Church and the taste of high aristocratic circles; from this structuring arose the difference between the “official” art of the Counter-Reformation (which nurtured the aesthetics of the altarpiece) and the “unofficial” art, intended for the art market and consumption in a semi-private or completely profane social setting. The once unquestionable space of religion was thus split into the “micro-spaces” of politics and art, with their own special systems of legitimization.
Anton Vlatković (1725.? – Grobnik, 1785.): nepoznati slikar djelatan u Rijeci i Primorju i njegova obitelj
Authors: Vlaše Antonella , Kudiš Nina
Published: March 2022

Utemeljitelj obitelji lokalno vrlo uglednih drvorezbara i slikara, aktivne u Rijeci i na području Hrvatskog primorja, bio je Mihovil Zierer (? – Grobnik, 28. travnja 1739.). On je imao tri sina i dvije kćeri: najstariji sin, Anton Florentin, bio je svećenik i kanonik zborne crkve grada Grobnika, Josip je bio graditelj orgulja – organifex, dok je Fran bio drvorezbar poput oca. Mihovilova starija kći zvala se Marijana i bila je udana za riječkog slikara kranjskog podrijetla Ivana Krstitelja Fayenza (Višnja Gora, 1690. – Rijeka, 8. rujna 1768.), a najmlađa je kći Elizabeta iz svojeg prvog braka, s izvjesnim Vlatkovićem, imala sina Antona (1725.? – Grobnik, 1785.) koji je također bio slikar. Njegov je opus do sada bio u potpunosti nepoznat, a u ovom mu se radu pripisuju sljedeća djela: Sv. Luka slika Bogorodicu (župna crkva Sv. Luke, Rukavac), Sv. Ivan Krstitelj propovijeda u pustinji (crkva Sv. Marije od Porta, Bakar), Bolesnik moli svete Kuzmu i Damjana za ozdravljenje (crkva Sv. Kuzme i Damjana, Sv. Kuzam) i vjerojatno Sv. Aja (dominikanski, nekad augustinski, samostan Sv. Jeronima u Rijeci).
Eficiencia técnica del frijol caupí (Vigna unguiculata L. Walp) en la Región Caribe de Colombia
Authors: Martínez-Reina Antonio Maria , Cordero-Cordero Carina Cecilia , Tofiño-Rivera Adriana Patricia
Published: March 2022

Introducción. Dentro de los sistemas de producción de la economía campesina en la Región Caribe, el frijol caupí (Vigna unguiculata L. Walp) es importante dada su calidad nutricional. Hay pocos estudios sobre la asignación de factores de producción por parte del productor. Objetivo. Analizar y determinar la eficiencia de la producción de frijol caupí en las regiones productoras del Caribe de Colombia. Materiales y métodos. Entre 2018 y 2020 se llevó a cabo el estudio en el que se utilizó la información aplicada a 31 unidades productivas de frijol caupí en los departamentos de Córdoba, la Guajira y el Cesar, en una muestra seleccionada al azar mediante el método de muestreo aleatorio simple. A la muestra se aplicó una encuesta estructurada sobre datos de insumos usados en la producción como mano de obra, semilla, fertilizante. Se calcularon las estadísticas descriptivas, medidas de dispersión, análisis de correlación, regresión y para efectos de evaluar la eficiencia y aporte de cada factor a la producción, se formuló un modelo econométrico tipo Cobb Douglas. Resultados. Se generó información sobre la contribución de cada factor a la producción, donde se destaca la semilla y el fertilizante como los de mayor aporte. Conclusión. El agricultor, fue eficiente por cuanto se evidenció una relación directa entre el aumento de los insumos y las cantidades producidas, además, la brecha tecnología es estrecha del orden del 8 %, con rendimientos a escala creciente por la relación directa entre el aumento de los insumos y el aumento del producto.
Exogenous application of agmatine improves water stress and salinity stress tolerance in turnip (Brassica rapa L.)
Authors: JALAL Rewaa S. , ABULFARAJ Aala A.
Published: March 2022

This study was carried out to determine the consequence of foliar application of agmatine (0 and 0.5 mM), on growth, physiological and biochemical traits, and yield of turnip (Brassica rapa L.) plants grown under water stress or salt stress conditions. The effect of three irrigation regimes (100%, 80% and 40% of field capacity) and three salt concentrations (0, 100 and 200 mM NaCl) on turnip plants grown in pots under greenhouse conditions were studied.  Water deficit developed at 40% Field capacity (FC) and salinity stress, especially at 200 mM, resulted in signiﬁcant decreases in all growth parameters when compared to control plants (100% FC) including root length and diameter as well as shoot weights per plant. Water stress and high salt stress negatively affected most physiological and biochemical characteristics such as total chlorophyll, photosynthetic rate, stomatal conductance, and transpiration rate. Water use efficiency (WUE) increased under 80% FC or 100 mM NaCl. Antioxidant enzymes activity, catalase and peroxidase and glutathione reductase, increased with water stress and salt stress. Foliar application of agmatine seemed to alleviate the adverse effects of water stress and salt stress on turnip. Alleviating harmful effects of salt stress and enhancing water stress tolerance by agmatine was associated with improving leaf gas exchange, antioxidant enzymes and protein profile.
Introduction pages
Authors: SESTRAS Radu E.
Published: March 2022

The papers published in Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Issue 4, Volume 49, 2021 represent new exciting researches in different topics of life science, respectively in plant science, horticulture, agronomy and crop science. Among the interesting articles we invite you to find news about: Trehalose induced drought tolerance in plants: physiological and molecular responses; Taxonomy, distribution, epidemiology, disease cycle and management of brown rot disease of peach (Monilinia spp.); Promoter activity analysis and transcriptional profile of Ginkgo biloba 1-Deoxy-D- Xylulose 5-Phosphate reductoisomerase gene (GbDXR) under abiotic stresses; Identifying strawberry DOF family transcription factors and their expressions in response to crown rot; Analysis of codon usage pattern in Lonicera × heckrottii ‘Gold Flame’ based on chloroplast genome; Biofortification with copper nanoparticles (Nps Cu) and its effect on the physical and nutraceutical quality of hydroponic melon fruits; Effect of gibberellin, nano-nutrition with titanium, zinc and iron on yield and some physiological and qualitative traits of white beans; Seasonal variation of arbuscular mycorrhizal fungi in ecotone forests of the northern region of Brazilian Amazonia.
Phosphatidylcholine content in soybean: Genetic variability and the effect of growing year
Authors: ANSHU Aseem K. , KUMAR Vineet , RANI Anita , TAYALKAR Trupti , PARMAR Hamendra S.
Published: March 2022

Information on the genetic variability of phosphatidylcholine (PC) content in soybean (Glycine max L.) is scanty. In the present investigation, estimation of PC content in 408 soybean accessions from 15 countries revealed a range of 2.04-8.80 mg/g soy flour, thereby exhibiting about 4.3-fold genetic variation. Both high (> 8.00 mg/g soy flour) and low PC (< 4.50 mg/g soy flour) genotypes identified in 2018 were raised in 2019 to investigate the effect of growing year on PC content in soybean seeds. Effect of growing year and genotype × growing year interaction on PC content was found to be significant (p < 0.05). Results suggested that higher average minimum temperature during the seed filling stage may increase PC content. Mapping populations developed from high and low PC genotypes from diverse genetic background may be used for identifying genomic regions underlying biosynthesis of PC in soybean seeds.
Protective role of glycine and kolaviron on lipopolysaccharide-induced alterations of raw U937 cells and U937-derived macrophages
Authors: OKOKO Tebekeme , NDONI Solomon A.
Published: March 2022

The effect of glycine and kolaviron on lipopolysaccharide-induced U937 cell damage and activation of U937-derived macrophages was studied. U937 cells were incubated with either glycine or kolaviron or both for 24 h before exposure to lipopolysaccharide. Cell viability and production of reactive oxygen species (ROS) were later assessed. In the other experiment, the U937 cells were transformed to the macrophage form using phorbol 12-myristate 13-acetate and incubated with or without glycine or kolaviron or both before exposure to lipopolysaccharide. Production of TNF-α, IL-1, IL-6 and NO were later assessed. The expression of the antioxidant enzymes- superoxide dismutase (SOD) and catalase (CAT) was also evaluated via reverse transcription polymerase chain reaction (RT PCR). It revealed that lipopolysaccharide caused significant cell death and production of reactive oxygen species that was reduced by glycine and kolaviron. Glycine and kolaviron also reduced lipopolysaccharide-mediated secretion of TNF-α, IL-1, IL-6 and NO in U937-derived macrophages. In some cases, pre-incubation of cells with both glycine and kolaviron was better than the individual responses. Glycine and kolaviron also reduced lipopolysaccharide-induced alterations in the expression of SOD and CAT (p<0.05). The study shows that both glycine and kolaviron (either separately or in combination) reduced lipopolysaccharide-mediated alterations in U937 cells and U937-derived macrophages.
Effect of calcium nitrate treatment on reduction of berry shattering in ‘Cheongsoo’ grape cultivars
Authors: PARK Young-Sik , LEE Je-Chang , KIM Joo-Hyun , JEONG Haet-Nim , HEO Jae-Yun
Published: March 2022

This study was conducted to examine the effect of calcium nitrate (CaNO3) on berry shattering in and the fruit characteristics of the ‘Cheongsoo’ grape cultivar. The rate of berry shattering was reduced regardless of CaNO3 concentration when the detachment force of the abscission zone at the stalk-berry junction increased. When 0.8% CaNO3 was treated, the berry shattering rate decreased by approximately 40% compared to the control; this was the lowest value. Furthermore, fruit quality declined and side effects were not observed following the CaNO3 treatment although fruit firmness also increased by 57% compared to the control. These results indicate that treatment with CaNO3 can contribute to stable production of ‘Cheongsoo’ grapes.
STUDYING A MOVEMENT UP CLOSE: GRASSROOTS ENVIRONMENTALISM
Authors: Staggenborg Suzanne
Published: March 2022

Qualitative fieldwork methods, particularly participant observation, afford a close-up look at the dynamics of social movements, allowing researchers to directly observe processes such as strategic decision making and the creation of social movement communities. Extended fieldwork allows us to see how movements and organizations change over time. This article reports on the value of long-term participant observation in a study of grassroots environmentalism in Pittsburgh. I show how the method increases our understanding of how and why people get involved in the movement; the importance of tactics in mobilization; and the challenges of organizing and developing strategy in movement organizations. The study compares organizations that vary by structure and ideology and points to the importance of looking at the multiple and lasting impacts of movement actions and campaigns. The article also notes some of the difficulties of fieldwork, the desirability of team research and multimethod studies, and suggestions for future research.
Toppling of a Trona Pinnacles Spire following the Mw 5.5 Ridgecrest Aftershock of June 2020
Authors: Donnellan Andrea , Garcia-Suarez Joaquin , McPhillips Devin , Asimaki Domniki , Goulet Christine , Meng Xiaofeng , Devine Savannah , Lyzenga Gregory
Published: March 2022

The 2019 Mw 7.1 Ridgecrest California earthquake rupture passed within 4 km of the Trona Pinnacles, a large group of tufa rock pillars. Reconnaissance following the Ridgecrest mainshock documented fresh damage to several of the Pinnacles. Repeated aerial photogrammetric surveys also documented damage during subsequent aftershocks. Here, we describe the photogrammetric data with emphasis on a specific rock spire that toppled during an Mw 5.5 aftershock. We calculate the volumes of the intact spire and of its subsequent debris. To explore the utility of the pinnacles as fragile geologic features for constraining past earthquake shaking intensity, we calculate the quasi static, horizontal acceleration required to break the spire at its base. We also examine the response of this feature to observed shaking using a dynamic model of the spire. In this case, we find that the quasi-static estimate provides a conservative maximum constraint on fragility. The dynamic model of the spire suggests that shaking during the Mw 7.1 mainshock likely generated tensile stresses in excess of the spire’s bulk strength, thereby making it vulnerable to collapse in subsequent aftershocks.
La migración ¿derecho o flagelo social?
Authors: De León Vargas Georgina , Estarita Soto Angie Camila , Orozco Rodríguez Mayerli
Published: March 2022

Hablar de la migración como un movimien-to social, económico y político, es un asunto que concierne a todos, en Colombia desde 1950 se comenzó a manifestar el desarrollo de este fenómeno en cantidades incalcula-bles, que ha afectado en mayor grado la di-mensión interna de los países receptores en distintas áreas de desarrollo.
Fuel Cell Co-generation and PCS Control for Suppressing Frequency and Voltage Fluctuation due to PV Power
Authors: Yamamoto Shuhei , Mitani Yasunori , Watanabe Masayuki , Satake Akihiro , Ushifusa Yoshiaki
Published: March 2022

The purpose of this study is to control active power of fuel cell co-generation system and reactive power of power conditioning system to suppress frequency fluctuation in power system and voltage fluctuation in distribution system caused by variation of photovoltaic power. The governor-free control for fuel cell co-generation system is applied to reduce frequency fluctuation in power system. A method which controls power fluctuation in distribution system for power conditioning system is applied to reduce voltage fluctuation. The authors reveal the effectiveness of the method by a simulation model. The results suggest that fuel cell co-generation system and power conditioning system work to reduce each targeted fluctuation.
An Examination of Private Real Estate Developers’ Perspectives on Effectiveness of Government Support to the Ghanaian Housing Industry
Authors: Afrane Ebenezer , Ariffian Bin Bujang Ahmad
Published: March 2022

The centric role of housing in socio-economic development of nations makes many governments across the world play significant direct or indirect role in improving the housing industries for national development. Nonetheless, some governments, particularly in developing countries, have reduced their support for the housing industry to the creation of an enabling environment as a result of advised from World Bank. This appears to be failing due to economic challenges. Consequently, the entire Ghanaian housing sector has been left to private developers, who have very limited capacity to address the country's rising housing deficit, among other challenges. The purpose of this study is to make suggestions to the government to consciously improve its assistance to private real estate developers to help them in overcoming the challenges they face in the housing industry. The study was quantitative and made use of a survey questionnaire that was designed after reviewing relevant literature. Fifty-two (52) registered members of Ghana Real Estate Developers with offices were purposively sampled, and the data collected was analysed by SPSS v20 using descriptive statistics: cross-tabulations (correlation matrix) and frequencies. The findings revealed that the government's support to private real estate developers in housing development was inadequate. As a result of the affordability issues, private developers are discouraged from investing in housing for low to middle income households. Therefore, the study concluded that government commitment to the housing industry is critical, including streamlining the land tenure system, establishing land banking, assisting in the provision of infrastructure development, and assisting them in mortgage financing schemes.
Hair loss from scalp among women: Does serum levels of iron, cobalamin and folic acid matter?
Authors: Sharanappa Preetham , B N Sandhyalakshmi
Published: March 2022

Hair fall from the scalp is a common complaint by females attending a dermatologist’s out-patient clinic. The most common cause is telogen effluvium and the most common pattern is chronic diffuse non-scarring hair fall from the scalp.

The aim of our study was to analyze deficiency status and correlate hemoglobin, ferritin, cobalamin, folic acid in females of reproductive age group.

This is a descriptive study was conducted in the DVL department of a tertiary care medical college hospital between 2018-2019. Clinical and demographic data were collected and hemoglobin, ferritin, cobalamin, folic acid levels were investigated.

A total of 85 patients were studied. Mean Hemoglobin was found at 11.92 g/dl and Anemia was recorded at 59.32%. Ferritin levels were lower than normal in 90% of the cases. Folate levels were in the normal range in the majority of our cases. Cobalamin was deficient in 50% of our patients.

Ferritin and cobalamin levels were better indicators than hemoglobin levels alone in assessing chronic nonscarring hair loss from the scalp in females of reproductive age group.