bluuebunny/crossref_metadata_2025 huggingface dataset:
Suicide risk assessment and depressive symptoms among Spanish adolescent bully-victims: Evidence for the importance of emotional intelligence and sex
Authors: Quintana-Orts Cirenia , Rey Lourdes , Mérida-López Sergio , Extremera Natalio
Published: August 2022

The aim of this study is to explore a model examining how emotional intelligence (EI), sex, depressive symptoms and suicidal thoughts and behaviours (STB) may interact. The sample included 380 Spanish adolescent bully-victims (61.6% boys; mean age = 14.38 years). The results indicated that EI is a significant negative predictor of decreased STB and that this relation is fully mediated by depressive symptoms. This effect was moderated by sex, such that the mediation is stronger for girls compared to boys. The promotion of EI may be core in the development of prevention programmes for suicide, especially among female bully-victims.
Parenting interventions targeting early parenting difficulty: A scoping review
Authors: Bailey Sherryn , Hurley John , Plummer Karin , Hutchinson Marie
Published: August 2022

Parent and child wellbeing are reciprocal. Attentive, responsive parenting, is contingent on parental wellbeing. Insights into mechanisms of early parenting interventions that seek to improve parent and child outcomes are needed. This scoping review aimed to systematically map research reporting on parenting interventions for parents experiencing early parenting difficulty. A secondary aim was to synthesise existing research using a realist lens, to provide context, mechanism and outcome insights into elements of early parenting interventions. A systematic search was conducted across six databases within the publication period of 2010–2020, to identify evidence on interventions targeting early parenting difficulty. Using pre-determined inclusion criteria, fifteen studies were selected for review. Deductive reflexive thematic analysis identified three themes: conceptual disparities in early parenting difficulty, early parenting intervention diversity and an absence of theory to explain interventions or outcomes. Neither early parenting difficulty nor the theoretical basis for early parenting interventions were well defined. Identification of contexts, mechanisms and outcomes of early parenting interventions is a unique contribution of this study. These insights may be used to inform planning, implementation and evaluation activities to promote context-focused, early parenting interventions targeting a critical phase of child development.
Media crisis and its effects on digital journalism careers in Canada
Authors: Pereira Fábio Henrique
Published: August 2022

This article discusses how the evolution of media industry in Canada affects the construction of identities and careers in digital journalism. It is based on 17 in-depth interviews with professionals working in Canadian Anglophone and Francophone media. Based on an interactionist theoretical approach, this article underlines how journalists negotiate their career project in a scenario of precariousness and deterioration of the job market in Canadian journalism. In this regard it highlights the strategies of resistance and resilience adopted by some interviewees in contrast to the international discourses that aim to restructure their practices and identities. This results in a conservative approach to adapting to the professional identity in digital journalism – which in fact translates into segmentation and diversification of the status that comes with this profession.
A Prognostic Nomogram for Predicting Overall Survival in Patients With Small-Cell Carcinoma of the Uterine Cervix: A SEER Population-Based Study
Authors: Chen Yusha , Chen Jiancui , Lin Xiaoqian , Zheng Jinwen , Li Suyu , Zheng Xiangqin
Published: August 2022

Background: This study aimed to develop a prognostic model based on the Surveillance, Epidemiology, and End Results (SEER) database to predict the overall survival (OS) of small cell carcinoma of the uterine cervix (SmCC). Methods: Between 1975 and 2016, a total of 401 patients were included, and their comprehensive sociodemographic and clinicopathological characteristics were collected. Univariate and multivariate Cox regression models were used to screen for independent prognostic factors. The identified factors were used to conduct a nomogram for predicting the OS of SmCC. The performance of the nomogram was determined using area under the receiver operating characteristic curve (AUC), concordance index (C-index), calibration curve, and decision curve analysis (DCA) metrics. Results: The median survival time of all patients was about 24 months (95% confidence interval [95% CI] [1.50-2.17]). Age (hazard ratio [HR] = 1.693 for 45-59 vs 21-34, 95% CI [1.140-2.513], P = .009; HR = 2.836 for 60-92 vs 21-34, 95% CI [1.851-4.345], P < .001), positive nodes (HR = 2.384, 95% CI [1.437-3.955], P < .001), regional nodes number ≥12 (HR = 0.500, 95% CI [0.282-0.886], P = .018), and treatment method (HR = 0.409 for surgery vs no, 95% CI [0.267-0.628], P < .001; HR = 0.649 for chemotherapy vs no, 95% CI [0.478-0.881)], P = .006) were independent factors of OS. Young patients who had surgical resection or chemotherapy, negative lymph nodes, and regional lymph nodes ≥12 had a longer survival time. These clinical factors were utilized to construct a nomogram for predicting OS. The AUC and C-index were higher than 0.7, indicating the good discriminating ability of the nomogram. The calibrations were all around the 45-degree line, indicating excellent consistency between the prediction of the model and actual observations. The DCA plots supported the clinical utility of the nomogram. Conclusion: The constructed nomogram is expected to help predict the prognosis of SmCC and guide patient treatment.
FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer
Authors: Li Ting , Huang Silin , Yan Wei , Zhang Yu , Guo Qiang
Published: August 2022

Background: Forkhead box F2, a member of the Forkhead box transcription factor superfamily, plays an important role in several types of cancer. However, the mechanisms of Forkhead box F2 in the progression of colorectal cancer remain unclear. PRUNE2 is closely associated with prostate cancer, neuroblastoma, glioblastoma, and melanoma. The relationship between Forkhead box F2 and PRUNE2 in colorectal cancer remains unknown. Method: We investigated the effects of Forkhead box F2 upregulation on colorectal cancer cell behavior in vitro using Cell Counting Kit-8, colony formation, flow cytometry, Transwell, reverse transcription quantitative polymerase chain reaction and Western blot analyses. Nude mouse xenografts were established to investigate the effect of Forkhead box F2 upregulation on the growth of colorectal cancer cells. Dual-luciferase reporter assays were performed to confirm the Forkhead box F2 regulation of PRUNE2 transcription. A series of in vitro assays was performed in cells with Forkhead box F2 upregulation and PRUNE2 knockdown to elucidate the function and regulatory effects of Forkhead box F2 on PRUNE2 transcription in colorectal cancer. Results: Forkhead box F2 was downregulated in colorectal cancer tissues compared with adjacent tissues. Forkhead box F2 overexpression significantly suppressed the proliferation and invasion of colorectal cancer cells in vitro and in vivo. Moreover, Forkhead box F2 directly targeted PRUNE2 to promote its transcription in colorectal cancer cells. Furthermore, PRUNE2 mediated the Forkhead box F2-regulated proliferation and invasion of colorectal cancer cells. Additionally, we demonstrated a significant positive correlation between Forkhead box F2 and PRUNE2 mRNA levels in colorectal cancer tissues. Conclusion: These results indicated that Forkhead box F2 and PRUNE2 in combination may serve as a prognostic biomarker for colorectal cancer and that Forkhead box F2 upregulation inhibits the proliferation and invasion of colorectal cancer cells by upregulating PRUNE2.
Patient-Reported Outcome of Functional Cognition for Traumatic Brain Injury: Item-Level Psychometrics
Authors: Wen Pey-Shan , Waid-Ebbs Julia , Heaton Shelley , Velozo Craig
Published: August 2022

A patient-reported functional cognition measure that can bridge neuropsychological tests and ecological validity is lacking. The purpose of this study was to present the initial item-level psychometrics of a functional cognition item bank, the Functional Cognition–Patient-Reported Outcome (FC-PRO). Confirmatory factor analysis, Rasch analysis, and convergent validity were conducted to establish item-level psychometrics of the FC-PRO item bank. Four of the six domains met essential unidimensionality criteria; all domains met rating scale criteria; domains had relatively few misfitting items (3%–13%); person reliability (.8–.92), and person strata (2.97–4.29) were satisfactory; the domains showed convergent validity for five of six domains. The FC-PRO showed adequate initial item-level psychometrics for researchers/clinicians to measure specific functional cognitive domains in patients with traumatic brain injury (TBI). This study provides the foundation for the development of future short forms, computer adaptive tests, and keyform recovery maps of patient-reported functional cognition to facilitate clinical utilization.
Florida Trauma Responsive and Caring Environment: Exploratory Factor Analysis of a Staff and Youth Trauma-Informed Self-Assessment Tools in Juvenile Residential Programs
Authors: Sheppard Keller G.
Published: August 2022

Trauma exposure is pervasive among juvenile justice involved youth. A growing appreciation for the prevalence of trauma and the challenges it poses to successful treatment has prompted youth serving organizations to adopt policies and practices that are consistent with trauma-informed care (TIC). Despite increased interest in integrating TIC into service provision, research on various TIC initiatives and juvenile outcomes is severely underdeveloped. Presently there are no validated instruments that can measure TIC at the organizational level in criminal and juvenile justice settings. To address this gap, the present study evaluates the internal structure and psychometric properties of two self-assessment surveys—for youth and staff—intended to measure organizational-level TIC in Florida Department of Juvenile Justice residential commitment programs. Data from 2761 youth and 2781 staff survey responses from 59 programs demonstrates that these instruments possess strong psychometric properties capable of measuring several distinct aspects of organizational TIC in a juvenile justice setting.
When Faith Hurts: Clients’ Experience of the Therapeutic Relationship and a Counselor's way of Being on the Resolution of Religious and Spiritual Struggles
Authors: Campbell Mentanna
Published: August 2022

Unaddressed religious and spiritual struggles can lead to poor mental health, making identifying the pathways individuals take towards growth of great importance. This hermeneutical phenomenological study explored the lived experiences of individuals who sought counseling to address their religious and spiritual struggles, focusing on how the therapeutic relationship and the counselor's way of being influenced growth pathways, as these factors are most predictive of positive outcome. The researcher highlights key findings and elaborates on clinical implications.
Interoperability analysis via agent-based simulation
Authors: Pescatore Melissa , Beery Paul
Published: August 2022

This paper demonstrates an approach for the use of agent-based simulation, supported by model-based systems engineering products, to analyze interoperability. To demonstrate the approach, a representative maritime search-and-rescue (SAR) operation is simulated in the agent-based simulation program Map-Aware Non-Uniform Automata (MANA). The MANA SAR model is used to assess interoperability decisions at organizational, operational, and technical levels and to highlight dependencies between decisions at each level of interoperability. Analysis indicates that, within the MANA SAR model, organizational interoperability decisions have the largest impact on operational performance but that organizational challenges may be overcome with substantial investment at both the operational and technical levels of interoperability.
Fog, friction, and control in organized conflict: punctuated transitions to instability
Authors: Wallace Rodrick
Published: August 2022

We explore the effects of Clausewitzian fog and friction using a data rate theorem–based model of the phase transition from control to failure for inherently unstable systems that include, but are not limited to, the many possible modalities of organized conflict. Fog-and-friction challenge any and all cognitive structures facing dynamic patterns of threat or opportunity, whether control is manifested through an institution, a machine entity, or some composite. The fundamental nature of challenge appears independent of the degree of sophistication of those institutions, entities, or composites, and of the technical modalities employed. The dialog/Zweikampf of organized conflict is—and will remain—an intimate and most human enterprise. Implications for other existential threats of inherently unstable circumstance, like pandemic disease or climate change, are evident.
Virtual Heterotopias and the Contested Histories of Kowloon Walled City
Authors: May Lawrence
Published: August 2022

Hong Kong's Kowloon Walled City has found new life in videogames during the three decades since its demolition, taking on unstable and sometimes contradictory forms when reimagined through virtual architecture. At stake in these acts of memory are the historical discourses surrounding everyday life in Kowloon Walled City, its uncertain political and cultural status, and ongoing postcolonial debates concerning Hong Kong identity. I analyze Kowloon's Gate, Shenmue II, and Mr Pumpkin 2: Walls of Kowloon to uncover the contestation of the city's histories through the types of spaces Michel Foucault described as heterotopic: at once real and unreal, and existent and non-existent. This analysis reveals the fluid nature of cultural memory and historical discourse in videogame spaces, as well as how virtual spatiality and the past can be used together to understand and define the present.
Treatment of ruptured intracranial aneurysms using the novel generation of flow-diverters with surface modification: A systematic review and meta-analysis
Authors: Monteiro Andre , Khan Asham , Donnelly Brianna M , Kuo Cathleen C , Burke Samantha M , Waqas Muhammad , Housley Steven B , Cappuzzo Justin M , Davies Jason M , Snyder Kenneth V , Levy Elad I , Siddiqui Adnan H
Published: August 2022

Background

Surface modification of flow diverters (FDs) has been explored as a solution for reducing thrombotic risk of these devices, without necessarily using dual antiplatelet therapy (DAPT). If effective, this could pose a promising alternative for treatment of ruptured aneurysms not amenable to other modalities.

Methods

We performed a comprehensive search of PubMed, MEDLINE, and Embase databases following Preferred Reporting Items for Systematic reviews and Meta-analyzes guidelines. We included articles reporting use of surface-modified FDs for treatment of ruptured aneurysms. Demographics, subarachnoid hemorrhage (SAH) severity, aneurysm characteristics, devices used, periprocedural complications, angiographic outcomes, and mortality were extracted for sample size-based weighted analysis.

Results

Six studies comprising 59 patients with 64 aneurysms were included. Mean patient age was 56.6 ± 6.3 years and 60.6% (95% confidence interval [CI], 46.7–72.9%) were women. The anterior circulation was the location in 60.4% (95%CI, 45.5–73.5%) of aneurysms; 41.8% of the aneurysms were saccular (95%CI, 29.3–55.4%), 16.7% were fusiform (95%CI, 8.3–30.8%), 29.9% were dissecting (95%CI, 12.8–55.4%), 24.4% were blood-blister (95%CI, 15.2–36.7%), and 5.7% were mycotic (95%CI, 2–15.1%). Poor SAH grade was reported in 46.9% (95%CI, 33.3–60.9%). Adjunctive coiling was used in 33.2% (95%CI, 12.4–63.6%). Periprocedural thromboembolic and hemorrhagic complications occurred in 20% (95%CI, 7.1–45.1%) and 8.8% (95%CI, 3.7–19.5%), respectively. Complete occlusion was achieved in 76.4% (95%CI, 58.1–88.3%); no retreatments during follow-up were reported. Overall mortality was 15.1% (95%CI, 7.7–27.6%). There were no differences between single antiplatelet therapy (SAPT) and DAPT regimens with respect to periprocedural thromboembolic complications ( P = 0.09), hemorrhagic ( P = 0.834) complications, and mortality ( P = 0.312).

Conclusion

Surface-modified FD treatment of ruptured aneurysms resulted in high rates of thromboembolic complications and acceptable rates of hemorrhagic complications. A considerable proportion of aneurysms were nonsaccular. Rates of complete occlusion were high and retreatment were low. Importantly, no statistically significant difference was found between SAPT and DAPT with respect to complications and mortality.
Micro-snare retrieval as bail-out technique for a distally migrated WEB-device: A case report
Authors: Radu Răzvan Alexandru , Gascou Grégory , Derraz Imad , Cagnazzo Federico , Costalat Vincent
Published: August 2022

Intra-procedural intrasaccular device migration is an uncommon complication of endovascular treatment of wide-neck aneurysms. We report the case of a 52-years old Caucasian male who presented with a 3 × 3 mm posterior facing top of the basilar aneurysm in which treatment with WEB-SL (Woven EndoBridge-single layer) device was tempted. Inadvertent WEB migration in the right posterior cerebral artery occurred after detachment. Two retrieval attempts were performed using a combined technique with two different stent-retrievers and a 5-Fr distal access catheter. Upon WEBectomy attempt, the device rolled over the stents, and the passages were unsuccessful. The device was successfully removed using a microSnare, catching and retrieving it inside the 5-Fr distal access catheter. Micro-Snare is an effective bail-out technique to recover migrated intrasaccular WEB devices in cerebral arteries.
Repurposing Molnupiravir as a new opportunity to treat COVID-19
Authors: Paruchuri Sahithi , Yetukuri Koushik , Nadendla RamaRao
Published: August 2022

With the emergence of new and re-emerging viral diseases, scientists have been working to produce new medications with novel targets and pathways. The discovery of safe and efficacious antiviral medicines is critical due to the constant introduction of new virus types and short lifetime of protection. Since the outbreak, there have been significant efforts to repurpose existing and licensed medications for rapid human testing and possible emergency use authorizations. The exploration of surviving medications for new restorative motives is known as drug repurposing. It is a successful, rapid, and highly reliable alternative to traditional drug methods. COVID-19 is being treated using a number of repurposed and new medicines. Molnupiravir is a repurposed Covid-19 medicine that was specifically developed to cure influenza and is used to treat mild to moderately ill Covid-19 patients with high risk of becoming seriously ill. The importance of medication repurposing, as well as the regulatory procedure for repurposed pharmaceuticals and Emergency Use Authorization in the United States, are summarized in this article.
Analysis of certain samples of phenazine dyes from the Historical Dyestuff Collection of the Technical University Dresden by liquid chromatography–mass spectrometry
Authors: Reinke Oliver , Machill Susanne , Hartmann Horst
Published: August 2022

By means of liquid chromatography–mass spectrometry and other analytical methods, a variety of different samples of the phenazine dye Chrysaniline hosted in the Historical Dyestuff Collection of the Technical University Dresden and registered mostly under the trade name Phosphine have been analysed. It was found that all the dyes analysed are mixtures of compounds with different numbers of methyl groups at their phenazine core. They result, hence, from the oxidation of technical aniline that contained several amounts of isomeric toluidines and traces of dimethylanilines.
Effect of different set configurations on barbell trajectories during the power snatch
Authors: Nagatani Tsuyoshi , Haff G Gregory , Guppy Stuart N , Poon Wayne , Kendall Kristina L
Published: August 2022

This study aimed to investigate the effect of different set configurations on barbell trajectories during a series of power snatch sets. Ten strength-power athletes (height: 1.78 ± 0.09 m, body mass: 88.7 ± 14.3 kg, age: 28.9 ± 4.8 years) with at least 6 months of training experience performing the power snatch participated in this study. Each participant completed three experimental protocols as part of a randomized repeated measures design. The three protocols tested were a traditional, cluster, and ascending cluster set protocol where training loads were increased across the repetitions contained within each set. All protocols required each participant to perform the power snatch with three sets of five repetitions at an average load of 75% of one-repetition maximum. Three-dimensional barbell trajectories were recorded using a motion capture system during each set protocol. Participants maintained barbell trajectories within each set of both traditional and cluster protocols. This result indicates that higher intensities (>75% of one-repetition maximum) than those used in this study should be used when using cluster sets that are designed to maximize the benefits of cluster sets for maintaining barbell trajectories during a series of power snatch sets performed for five repetitions. Additionally, participants displayed an increased barbell loop at the first repetition during the ascending cluster protocol. Therefore, coaches should only use this programming strategy for highly trained athletes who have already developed proper weightlifting technique to avoid a suboptimal barbell trajectory during the power snatch training session.
Surviving on the frontline: Retail security guards and their self-protection behaviours
Authors: Koeppen Benjamin , Hopkins Matt
Published: August 2022

Despite the rapid expansion of private security guarding over the past 30 years, the reactions of guards to working in situations where violence is a constant possibility are seldom discussed. This article analyses how retail security guards respond to the threat of, and the actual experience of, violence through their adaptation of self-protection measures. We identify that a range of measures are adapted, broadly compromising of the ‘proactive’ that prepare guards for potential future confrontation and those described as ‘inactive’ where guards may use avoidance tactics or methods of withdrawal for their own safety. The article considers motivational factors that drive the adaptation of proactive and inactive measures and develops a novel explanatory framework outlining how fears around violence can generate both functional and dysfunctional forms of worry in security guards. Finally, some implications of these findings for the private security sector are outlined.
The impact of COVID-19 on the hot food takeaway planning regulatory environment: perspectives of local authority professionals in the North East of England
Authors: Moore HJ , Lake AA , O’Malley CL , Bradford C , Gray N , Chang M , Mathews C , Townshend TG
Published: August 2022

Aims:

Planning regulations have been used to prevent the over-proliferation of hot food takeaways, minimising the impact of local obesogenic environments. To help mitigate the effects of lockdown, the UK government introduced temporary changes in March 2020 to Planning Regulations for England, allowing food retailers to open for takeaway services beyond ‘ancillary’ level without needing to apply for planning permission through permitted development rights (PDR). Businesses are required to notify their local authority (LA) when they implement PDRs. To better understand the impact of regulations on the policy and practice of key professional groups, Public Health England commissioned Teesside University to undertake scoping research in the North East of England.

Methods:

A focus group and interviews were conducted with 15 professionals from 7 of 12 North East LAs. Professions included Planners, Public Health Leads, Environmental Health Officers and Town Centre Managers. Data were analysed using a codebook thematic analysis approach. An interpretation meeting with some participants was conducted.

Results:

LAs were not aware of most businesses notifying them of new regulation adherence despite taking up PDRs, but were considered low-priority with many lacking formal recording procedures. There were concerns about health consequences of the changes, and consensus relating to ongoing issues with capacity across all professional groups, largely due to the continuing pandemic and absence of a strategy out of temporary measures. Concerns existed around ensuring cessation of restaurants trading as takeaways, and hygiene inspections backlog. Many (personally) saw new takeaways as a lifeline, offering broader menus and preserving local economies.

Conclusion:

Lack of information around the number of restaurants/pubs using PDR to trade as takeaway services, ongoing capacity issues of LAs and, at the time, the absence of a strategy post regulation changes, meant there were high levels of uncertainty regarding the impacts of these temporary measures.
Incidence, causes, and predictors of unsuccessful decannulation following prolonged weaning
Authors: Ghiani Alessandro , Tsitouras Konstantinos , Paderewska Joanna , Milger Katrin , Walcher Swenja , Weiffenbach Mareike , Neurohr Claus , Kneidinger Nikolaus
Published: August 2022

Background:

Liberation from prolonged tracheostomy ventilation involves ventilator weaning and removal of the tracheal cannula (referred to as decannulation). This study evaluated the incidence, causes, and predictors of unsuccessful decannulation following prolonged weaning.

Methods:

Observational retrospective cohort study of 532 prolonged mechanically ventilated, tracheotomized patients treated at a specialized weaning center between June 2013 and January 2021. We summarized the causes for unsuccessful decannulations and used a binary logistic regression analysis to derive and validate associated predictors.

Results:

Failure to decannulate occurred in 216 patients (41%). The main causes were severe intensive care unit (ICU)-acquired dysphagia (64%), long-term ventilator dependence following weaning failure (41%), excessive respiratory secretions (12%), unconsciousness (4%), and airway obstruction (3%). Predictors of unsuccessful decannulation from any cause were age [odds ratio (OR) = 1.04 year−1; 95% confidence interval (CI), 1.02–1.06; p < 0.01], body mass index [0.96 kg/m2 (0.93–1.00); p = 0.027], Acute Physiology and Chronic Health Evaluation II (APACHE-II) score [1.05 (1.00–1.10); p = 0.036], pre-existing non-invasive home ventilation [3.57 (1.51–8.45); p < 0.01], percutaneous tracheostomies [0.49 (0.30–0.80); p < 0.01], neuromuscular diseases [4.28 (1.21–15.1); p = 0.024], and total mechanical ventilation duration [1.02 day−1 (1.01–1.02); p < 0.01]. Regression models examined in subsets of patients with severe dysphagia and long-term ventilator dependence as the main reason for failure revealed little overlapping among predictors, which even showed opposite effects on the outcome. The application of non-invasive ventilation as a weaning technique contributed to successful decannulation in 96 of 221 (43%) long-term ventilator-dependent patients following weaning failure.

Conclusion:

Failure to decannulate after prolonged weaning occurred in 41%, mainly resulting from persistent ICU-acquired dysphagia and long-term ventilator dependence following weaning failure, each associated with its own set of predictors.
A COVID Constellation: A Case of Transverse Myelitis and Acquired von Willebrand Syndrome
Authors: Mbonu Collins , Molokwu Nneka , Matelski Alexander
Published: August 2022

The coronavirus disease 2019 (COVID-19) pandemic revealed a myriad of postinfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequelae, many of which remain poorly understood. We describe a rare presentation of a patient developing 2 simultaneous COVID-19 sequelae: transverse myelitis and acquired von Willebrand syndrome (AVWS). There have been numerous published case reports of patients developing transverse myelitis after a diagnosis of COVID-19. However, none have described AVWS as an observed complication from SARS-CoV-2 infection. To our knowledge, this case report is the first to describe AVWS as a result of COVID-19 infection, suggesting that patients with a prior diagnosis of COVID-19 are susceptible to developing this rare bleeding disorder.
Arthroscopic Extensor Carpi Radialis Brevis Tenotomy and Debridement Versus Debridement Alone for Refractory Lateral Epicondylitis: Clinical and MRI Evaluation
Authors: Li Hong , Yang Xiang Dong , Xue XiaoAo , Zhang Qingguo , Ye Lingchao , Hua Yinghui , Zhou Xiaobo
Published: August 2022

Background:

Arthroscopic debridement of the extensor carpi radialis brevis (ECRB) tendon is a widely accepted procedure used in refractory lateral epicondylitis. However, residual pain occurs in some patients.

Purpose:

To investigate the clinical effectiveness of arthroscopic extended debridement (ECRB tenotomy and debridement) in the treatment of lateral epicondylitis.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Patients with refractory lateral epicondylitis were consecutively recruited for this study. They underwent traditional ECRB debridement (control group) or extended ECRB debridement (ED group) under arthroscopy. The Disabilities of the Arm, Shoulder and Hand (DASH) score, visual analog scale (VAS) for pain, and Mayo Elbow Performance Score (MEPS) were used to compare elbow function between the groups at 3, 6, and 12 months postoperatively. Magnetic resonance imaging (MRI) was also performed to evaluate pathology at 12 months.

Results:

A total of 69 patients participated in the study (33 patients in the ED group and 36 in the control group). After surgery, all patients showed improvement on all 3 outcome scores. Compared with the control group, the ED group had significantly better postoperative MEPS and VAS scores at 3 months ( P ≤ .001 for both) and 6 months ( P ≤ .03 for both) but similar values at 12 months. DASH scores between groups were similar at all time periods. At the 12-month follow-up, no patients in the ED group reported pain with strenuous work. Return-to-work (RTW) times were also shorter in the ED group compared with the controls (8 ± 4 vs 18 ± 8 weeks; P < .001). Postoperative MRI assessments revealed no high signal intensities on the lateral epicondyle in the ED group, while there was an increased internal signal intensity on the lateral epicondyle in 83% of the controls.

Conclusion:

Collectively, the extended ECRB debridement technique resulted in enhanced pain relief in the early postoperative period as well as providing faster RTW times compared with the traditional debridement technique. At 1 year follow-up, there were no differences in outcome measures between groups, but residual abnormal MRI findings were more common in the traditional debridement group.
Feasibility of Measuring Frailty and Patient-Reported Outcomes During and After Post-Acute Skilled Nursing Facility Rehabilitation
Authors: Shi Sandra , McCarthy Ellen P. , Mitchell Susan L. , Kim Dae Hyun
Published: August 2022

Functional status and quality of life are not routinely assessed after skilled nursing facility (SNF) discharge. We determined feasibility of measuring frailty among adults ≥65 years admitted to SNF after hospitalization, and post-discharge outcomes. We calculated a frailty index (non-frail [≤0.25], mild frailty [0.26–0.35], moderate [0.36–0.45], and severe [>0.45]). After SNF discharge, we conducted serial telephone interviews measuring ability to perform functional activities and Patient Reported Outcome Measurement Information System (PROMIS) scores. Overall of 68 screened patients, 42 were eligible, and 24 (57.1%) eligible patients were enrolled. Of these, 5 (20.8%) were admitted after elective hospitalizations, 17 (70.8%) were female, and 11 (45.8%) had moderate-to-severe frailty. Frailty was measured in all participants in a mean 32.1 minutes. At 90 days, a total of three participants died, and two were lost to follow-up. Post-discharge functional status varied by frailty, with moderate-to-severe frailty having persistent impairment and lower PROMIS scores (worse quality of life) compared to those with no or mild frailty (38.2 [13.7] vs. 47.3 [8.1] p = .04). Measuring frailty and quality of life in older patients admitted to SNF is feasible. Furthermore, measuring frailty may help identify those at particularly high risk of poor recovery and lower quality of life after discharge.
Visualizing Gendered Attitudes toward Same-Sex Sexual Behavior in China over a Decade
Authors: Zhou Yun
Published: August 2022

Scholars have documented increasing cooptation of the institution of heteronormative family by the Chinese state in recent years to maintain its authoritarian control. China’s marriage law and population policies, entrenching heteronormativity and rendering LGBTQ people invisible, define marriages as between women and men and promote “high-quality” childbearing only within such unions. Much public attention on LGBTQ issues in China has focused on closeted gay men marrying unsuspecting women, uncritically pitting LGBTQ rights against women’s rights in the narratives constructed. Against this backdrop, this project visualizes the gender dimension in Chinese public attitudes toward same-sex sexual behavior. Using all six waves of the China General Social Survey conducted in the 2010s, the visualization demonstrates an enduring intolerance toward same-sex sexual behavior among both Chinese men and women on one hand and illustrates the liberalizing effect of egalitarian gender role ideology on the other.
Who Do We Model? A Brief Report Comparing Different Sources of Normative Influence on Adolescent Bystander Intervention
Authors: Rizzo Andrew J. , Li Carrie K. W. , Banyard Victoria L. , Edwards Katie M.
Published: August 2022

Adolescence is a critical period of development in which various socializing relationships can play an important role in shaping behavior. This study examined adolescents’ bystander helping in relation to their perceived norms supporting intervention in dating and sexual violence situations across four different norm-referent groups. Survey questions asked about students’ bystander behavior and perceptions of bystander norms based on whether the norm was endorsed by friends, parents, teachers, and people in town. Paper-and-pencil surveys were completed during the school day by high school students ( N = 609) in three different towns in northern New England. We used multinomial logistic regression to compare the impact of different norms on bystander behavior. Friend- and parent-referent bystander norms were both individually associated with increased helping behaviors. Multivariate analysis found only friend-referent norms were significantly related to more frequent helping behaviors. The implications of these results can inform norms-based prevention programs for adolescents.
Construct validity of the school-implementation climate scale
Authors: Thayer Andrew J. , Cook Clayton R. , Davis Chayna , Brown Eric C. , Locke Jill , Ehrhart Mark G. , Aarons Gregory A. , Picozzi Elissa , Lyon Aaron R.
Published: August 2022

Background

Implementation climate is an organizational construct theorized to facilitate the adoption and delivery of evidence-based practices. Within schools, teachers often are tasked with implementing universal prevention programs. Therefore, they are ideal informants when assessing school implementation climate for initial and continuous implementation improvement efforts. The purpose of this study was to examine the construct validity (i.e., factor structure and convergent/divergent validity) of a school-adapted measure of strategic implementation climate called the School Implementation Climate Scale (SICS).

Methods

Confirmatory factor analyses of SICS data, collected from 441 teachers in 52 schools, were used to compare uncorrelated and correlated first-order factor models and a second-order hierarchical model. Correlations with other school measures were examined to assess SICS convergent and divergent validities.

Results

Results demonstrated acceptable internal consistency for each SICS subscale ( αs > 0.80 for all subscales) and construct validity of the hypothesized factor structure of the SICS with three new scales. The hierarchical second-order factor structure with eight first-order factors was found to best model the SICS data. Correlations with other school measures were in the expected direction and magnitude.

Conclusions

Results from this study provide psychometric evidence that supports the use of the SICS to inform the implementation research and practice in schools.

Plain Language Summary

Schools are busy trying to implement various universal programs and systems to help support kids in their growth. Beginning and sustaining these efforts is quite challenging, and there is need for tools and ideas to help those implementation efforts. One concept is implementation climate, which is broadly the school staff’s perception of the implementation support for a given practice. However, no measure currently exists to help schools assess their implementation climate. The goal of our study was to adapt a measure of implementation climate used in other settings to the school environment. We used feedback from educational experts to make changes and used various analyses to determine if the newly adapted measure was psychometrically sound. Findings suggest the new measure is usable to guide implementation efforts in schools.
Combined immunosuppression for acquired hemophilia A: CyDRi is a highly effective low-toxicity regimen
Authors: Simon Barbara , Ceglédi Andrea , Dolgos János , Farkas Péter , Gaddh Manila , Hankó László , Horváth Robert , Kaposi Ambrus , Magyar Lászlóné , Masszi Tamás , Szederjesi Attila , Wohner Nikolett , Bodó Imre
Published: August 2022

Acquired hemophilia A (AHA) is a rare severe autoimmune bleeding disorder with significant morbidity and mortality. Although critical for disease control, there is no consensus for the best immunosuppressive regimen. Most authors use steroids first line, followed by other agents for steroid failures. Upfront combined regimens offer the advantage of reduced steroid exposure and toxicity as well as increased efficacy. We retrospectively analyzed data from 32 patients with AHA treated on an identical such institutional protocol: cyclophosphamide 1000 mg on days 1 and 22, dexamethasone 40 mg on days 1, 8, 15, and 22, and rituximab 100 mg on days 1, 8, 15, and 22 (the regimen was termed CyDRi). All patients received at least 1 cycle of CyDRi. If necessary, CyDRi was repeated until remission, no sooner than day 43 of the previous cycle. Bleeding control was rapidly achieved. The median time for bleeding control was 15.5 days (range, 0-429 days; interquartile range, 2.5-29.5 days). Thirty-one (96.8%) of 32 patients achieved durable complete remission (CR); 29 (90.6%) of 32 patients were alive at last follow-up, all of them in CR. The median time to reach first CR was 77 days (range, 19-939 days; interquartile range, 31-115 days). Toxicity and side effects were acceptable and milder than those of commonly used, prolonged steroid therapies. In conclusion, the CyDRi regimen produced markedly higher CR rates and overall survival than currently used sequential regimens. Taken together, CyDRi proved to be an attractive option for the immunosuppression of elderly patients with AHA.
Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura
Authors: Izquierdo Cristina Pascual , Mingot-Castellano María Eva , Fuentes Ana E. Kerguelen , García-Arroba Peinado José , Cid Joan , Jimenez Maria Moraima , Valcarcel David , Gómez-Seguí Inés , de la Rubia Javier , Martin Paz , Goterris Rosa , Hernández Luis , Tallón Inmaculada , Varea Sara , Fernández Marta , García-Muñoz Nadia , Vara Míriam , Zarzoso Miguel Fernández , García-Candel Faustino , Paciello María Liz , García-García Irene , Zalba Saioa , Campuzano Verónica , Gala José María , Estévez Julia Vidán , Jiménez Gemma Moreno , López Lorenzo José Luis , Arias Elena González , Freiría Carmen , Solé María , Ávila Idrovo Laura Francisca , Hernández Castellet José Carlos , Cruz Naylen , Lavilla Esperanza , Pérez-Montaña Albert , Atucha Jon Ander , Moreno Beltrán María Esperanza , Moreno Macías Juán Ramón , Salinas Ramón , del Rio-Garma Julio
Published: August 2022

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX.
Experimental study on the embedment strength of smooth dowels inserted in cross-laminated timber narrow side
Authors: Long Weiguo , Ou Jiajia , Sun Xiaofeng , Huang Xinyue , He Minjuan , Li Zheng
Published: August 2022

The embedment properties of the dowel-type fasteners is a fundamental parameter that can determine the shear resisting performance of the connections utilized in cross-laminated timber (CLT) structures. To investigate the embedment strength of the smooth dowels inserted in CLT narrow side, totally 504 CLT embedment specimens were tested to evaluate the effects of the influencing factors on the embedment strength, which included the loading angle, the embedment angle, the embedment position, the diameter of the dowels, and the gaps between the lumbers. The existing predictive equations of the embedment strength were validated based on the experimental results, and modified empirical equations were proposed for a more accurate prediction on the average embedment strength. It is found that when the loading direction with a loading angle of 90 degree is parallel to the adhesive layer, for the dowels embedded in the core layer and for those embedded between layers, the average embedment strength decreases by 27.89% and by 33.61% with an increase of the diameter from 8 to 24 mm, respectively. When the loading direction is perpendicular to the adhesive layer, the average embedment strength of the smooth dowels with an embedment angle of 90 degree is 85.25–218.96% higher than that of the dowels with an embedment angle of 0 degree. Furthermore, almost no drop can be identified for the embedment strength of the dowels with an embedment angle of 0 degree when the gap exists in their embedment position. A more accurate prediction on the average embedment strength can be achieved based on the modified empirical equations.
Antioxidative properties of phenolic compounds and their effect on oxidative stress induced by severe physical exercise
Authors: Kruk Joanna , Aboul-Enein Basil Hassan , Duchnik Ewa , Marchlewicz Mariola
Published: August 2022

Extensive research has found strongly increased generation of reactive oxygen species, free radicals, and reactive nitrogen species during acute physical exercise that can lead to oxidative stress (OS) and impair muscle function. Polyphenols (PCs), the most abundant antioxidants in the human diet, are of increasing interest to athletes as antioxidants. Current literature suggests that antioxidants supplementation can effectively modulate these processes. This overview summarizes the actual knowledge of chemical and biomechanical properties of PCs and their impact as supplements on acute exercise-induced OS, inflammation control, and exercise performance. Evidence maintains that PC supplements have high potency to positively impact redox homeostasis and improve skeletal muscle's physiological and physical functions. However, many studies have failed to present improvement in physical performance. Eleven of 15 representative experimental studies reported a reduction of severe exercise-induced OS and inflammation markers or enhancement of total antioxidant capacity; four of eight studies found improvement in exercise performance outcomes. Further studies should be continued to address a safe, optimal PC dosage, supplementation timing during a severe training program in different sports disciplines, and effects on performance response and adaptations of skeletal muscle to exercise.
CRANet: a comprehensive residual attention network for intracranial aneurysm image classification
Authors: Zhao Yawu , Wang Shudong , Ren Yande , Zhang Yulin
Published: August 2022

Rupture of intracranial aneurysm is the first cause of subarachnoid hemorrhage, second only to cerebral thrombosis and hypertensive cerebral hemorrhage, and the mortality rate is very high. MRI technology plays an irreplaceable role in the early detection and diagnosis of intracranial aneurysms and supports evaluating the size and structure of aneurysms. The increase in many aneurysm images, may be a massive workload for the doctors, which is likely to produce a wrong diagnosis. Therefore, we proposed a simple and effective comprehensive residual attention network (CRANet) to improve the accuracy of aneurysm detection, using a residual network to extract the features of an aneurysm. Many experiments have shown that the proposed CRANet model could detect aneurysms effectively. In addition, on the test set, the accuracy and recall rates reached 97.81% and 94%, which significantly improved the detection rate of aneurysms.