bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Community Economic Resilience in Response to Earthquakes in Jailolo Sub-District, North Maluku
Authors: Febriyanti Febriyanti , Martini Santi , Hidajah Atik Choirul , Dwirahmadi Febi
Published: June 2021

Background: The earthquake that hit the Jailolo sub-district in 2015 caused massive damage and loss. This catastrophic event affected not only impacted the local government's economy but also affected many communities, households and individuals living in these communities. Purpose: Aim of this study is to assess the economic resilience of communities in the Jailolo sub-district in response to earthquakes. Methods: This research was based on a descriptive observational study and employed a survey method to assess the economic resilience of communities in the Jailolo sub-district. The study was conducted in five villages, namely Tedeng, Payo, Saria, Matui, and Buku Maadu. The cut-off point for each indicator was classified as very high criteria (>1.05), high (0.95–1.05), moderate (0.85–0.94), low (0.74–0.84), and very low (≤0.73). Results: The proportion of community home ownership was found to be 100% (Resilience Factor Index (RFI)=1.67). The proportion of community work was 33.75% (RFI=0.68). The proportion of dual-income sources of communities in the Jailolo sub-district was 50.89% (RFI=1.02). The proportion of community income that exceeded the provincial minimum wage (PMW) was 8.71% (RFI=0.10). Based on the results of these indicators, the economic resilience of people in the Jailolo sub-district, which was obtained by considering the average RFI of each indicator, was 0.86. Conclusion: Community economic resilience in the Jailolo sub-district was found to be in the medium category. The highest and lowest resilience factors resulted from home ownership and income, respectively.
Isolation of Dermatophytes from Infected Stray Dogs in Selangor, Malaysia
Authors: Ridzuan P.M , Proveen K. , Siti-Arffah Kamarulzaman
Published: June 2021

Background: Dermatophytosis is one of the most common skin diseases that affects cats and dogs. Geographic factors play an important role in determining prevalence, showing high rates of prevalence in warm and humid environments. Purpose: The aim of this study was to determine the macroscopic and microscopic identification of different types of dermatophytes present on stray dogs. Methods: The design of this study was laboratory-based research. Each sample was collected from an infection site (nail, hair, or skin) that was identified by conducting a physical examination of a stray dog that was infected with fungi. The skin scraping, nail clipping, and fur cutting samples were collected from infected dogs and then cultured on Sabouraud Dextrose Agar (SDA). The cultures were incubated at 26°C for five weeks. The isolates of fungi were then examined macroscopically and microscopically. The Lactophenol Cotton Blue (LPCB) staining technique was used for fungi morphology identification. Results: Overall, the most common type of dermatophytes that affected the dogs were Trichophyton spp. (64.70%), Aspergillus spp. (10.10%), Microsporum spp. (7.20%), and Curvularia spp. (5.60%). Conclusion: This study revealed the most common dermatophyte infections found on stray dogs in Selangor, Malaysia. This study can assist investigators in understanding the prevalence of the dermatophyte burden in stray dogs and help prevent further complication, such as the spread of illness, especially zoonotic infection.
Associated Risk of Death from Covid-19 Infection in Patients with Hypertensive Co-Morbidities
Authors: Widyasari Nina , Basuki Hari , Wahjuni Chatarina Umbul
Published: June 2021

Background: The COVID-19 pandemic caused by the SARS-CoV-2 virus has left infected patients with comorbidities in severe and deadly conditions. Hypertension is a non-communicable disease (NCD) and is one of the most common comorbidities observed in COVID-19 patients. Purpose: This study aims to understand the relationship between hypertension and the risk of death through COVID-19. Method: The study employed a systematic review of journals. Journals and articles related to hypertension and COVID-19 were collected and analyzed. The inclusion criteria was COVID-19 articles pertaining to hypertensive patients, and the exclusion criteria was articles that did not use English as well as those that did not display full text. Result: Hypertension is a multifactorial disease. The presence of hypertension is often not realized by the sufferer. A COVID-19 infection can worsen the condition of the person and can cause damage to vital organs. The use of antihypertensive drugs of the angiotensin-converting enzyme inhibitor (ACEI) and the angiotensin receptor blocker (ARB) groups can be continued to be administered to hypertensive patients. There should be no cause for concern for these patients to develop COVID-19 infections by taking these drugs. Conclusion: The risk of developing hypertension is that it can cause organ damage and lead to various complications. The SARS-CoV-2 infection in people with hypertension as a comorbidity, could worsen the condition of the individual until death occurs. Thus, hypertension management is necessary to properly minimize the severity.
Use of Beds in The Event of a Scabies Infection in Boarding Schools
Authors: Sembodo Tjatur , Karyadini Hesti Wahyuningsih , Sanna Yusti Nur Aisyah
Published: June 2021

Background: Research on scabies in boarding schools has been widely carried out, however, the nature of transmission has not yet been analyzed. The transmission can occur due to the risk of direct contact when using shared beds. Purpose: This study aims to analyze the risk of bed usage in the event of a scabies infection in boarding schools. Methods: This study adopted a case-control design method. The independent variable was the use of beds, including using a shared bed and using one's own bed. The dependent variable was scabies, which was determined on the basis of the diagnostic criteria set for scabies. The sample size was 60 students, who had lived for at least four weeks in boarding schools. The sample comprised two groups: the group that used a shared bed (30 students) and the group that used their own beds (30 students). A non-probability sampling method was employed to record data. The data was collected by using a scabies checklist. Direct examinations and interviews were conducted at the Fathul Huda Demak and the Selamat Kendal boarding schools in February 2020. Statistical tests were carried out using chi-square analysis. Results: This study revealed the risk of developing scabies when a shared bed was used, with p=0.00 (p<0.05); OR=7.67; and 95%CI= 2.42–24.25. Conclusion: Students who used a shared bed in boarding schools were at 7.67 times the risk of developing scabies compared to students who used their own beds.
FORMULASI SOFT CHEWY COOKIES BEBAS GLUTEN DAN KASEIN BERBASIS KOMBINASI MOCAF DAN TEPUNG MILLET PUTIH UNTUK ANAK AUTISM SPECTRUM DISORDER
Free Gluten and Free Casein Soft Chewy Cookies Formulation with Combination of MOCAF and White Millet Flour Based for Children with Autism Spectrum Disorder

Authors: Prasetyo Kirana Dwiyanti , Atmaka Dominikus Raditya
Published: June 2021

Children with Autism Spectrum Disorder (ASD) have to eat a gluten-free casein-free diet due to their special condition. Casein is protein that contained in milk and milk-based product which are source of calcium. Their special condition make children with ASD have a low bone-mass than other children. Modifi ed Cassava Flour (MOCAF) and white millet fl our are free gluten food sources which have rich calcium that is needed to increase nutrient quality in soft chewy cookies. This study was aimed to determine the eff ect of MOCAF fl our and white millet fl our combination on acceptability and nutritional value of free gluten and free casein soft chewy cookies. This study was true experimental study with complete randomized design. This study used un-trained panelist including ASD children(7–11 years old (25 panelists) and their parents (25 panelists). There were 4 formulas in this study consisted of 1 control formula (F0) based on 100% wheat fl our, and 4 treatment formulas which were combination of MOCAF fl our and white millet fl our with a percentage ratio of combination F1 (0%:100%) ; F2 (50%:50%) ; and F3 (75%:25%). Kruskal Wallis statistical test results showed there were signifi cant diff erences of aroma, color, texture, and taste between each formula. Result of acceptability and nutritional value showed F3 as the best formula. Each 60 g soft chewy cookies F3 contains 176,4 mg of calcium which fulfi ll 18% of calcium adequacy for 7–11 year old children. Gluten-free casein-free soft chewy cookies with combination of MOCAF and white millet fl our are suitable as an alternative snack for ASD children.
O acesso à medicamentos: aspectos da judicialização da saúde
Authors: Hawerroth Maria da Graça Lepre , Sonoda Lucas Yuji , Andrade Raquel Dully , Santos Jaqueline Silva , Maia Maria Ambrosina Cardoso
Published: June 2021

Introdução: a judicialização da saúde é um fenômeno mundial, ético-filosófico e social em crescimento, que impacta de forma negativa nas finanças públicas e demonstra as mazelas do sistema de saúde. Objetivo: realizar uma revisão da literatura acerca da judicialização da saúde em que os insumos requisitados são medicamentos. Revisão de literatura: foi realizada uma revisão narrativa da literatura nas bases de dados Pubmed, Medline e Lilacs, abordando artigos publicados nos últimos 10 anos que abordassem a judicialização do acesso a medicamentos. Retornaram a busca 354 resultados e após os critérios de inclusão e exclusão, foram analisadas 27 publicações. Discussão: considerando a utilização da via judicial para acesso a medicamentos, os estudos apontam diversos desdobramentos, como o impacto financeiro, aspectos éticos e sociais, utilização de serviços públicos e privados, presença de medicamentos em listas oficiais de distribuição, além do aumento explosivo do número de casos relatados nos últimos anos. Conclusão: a judicialização da saúde apresenta discussões paradoxais quanto ao seu impacto negativo e a necessidade de atualização das listas oficiais de medicamentos.
History of the teaching profession in the memories of standard teachers of the alto Sertão Paraíbano between the decades of 1970 to 1980
Authors: Alves Rozilene Lopes de Sousa , Souza Renilfran Cardoso de
Published: June 2021

The history of Brazilian education has been the subject of research to analyze problems and perspectives that affect the analysis of problems and perspectives linked to the structuring and consolidation of the Brazilian educational system. Under this prism, the present work has as general objective, to understand the development of the teaching profession through stories and memories of normalist teachers, who acted, in the teaching in the Primary Education, in schools of the Sertão Paraibano (1970 and 1980). The research assumes the theoretical foundations on History, Memory, History of Brazilian Education and methodological procedures of qualitative research, with attention to data collection approaches through the history of oral expression, added by documentary research. The study will contribute to the characterization, discussion of the conceptions of Education and Society and their relationship on the constitution of the teaching identity, based on listening, writing and analysis of thematic oral histories of the collaborating teachers.
Formative experiences: methodological findings of training processes performed during the Covid-19 pandemic
Authors: Nunes Everton de Almeida , Santos Júnior Gilson Pereira dos , Carregosa Dean Lima
Published: June 2021

The pandemic has significantly impacted societies' ways of living around the world, reconfiguring everyday practices, including educational ones. Teachers had to become researchers open to experimentation with methodologies and technologies present in digital cultures and the formative experiences of the period became fertile fields of research for education. In this article, we share the methodological didactic findings found in the training process entitled "Use of Digital Interfaces for the Development of Pedagogical Practices in Times of Ubiquity", conducted by members of the Research Group on Education and Digital Cultures (E-CULT) at the Federal University of Sergipe in partnership with CESAD (UFS). It is a qualitative research with methodological approach in Research-Training in Cyberculture and dialogues with the foundations of multi-referentiality and complexity. The main methodological findings, which we analyze analytically, are: "Deconstruction of Hierarchies", "Insertion of Playfulness" and "Relay of Protagonism".
PARENTAL RESPONSIBILITY OF CHILDREN CRIME IN INDONESIAN CRIMINAL ADAT LAW
Authors: Fardiansyah Ahmad Irzal , Suseno Sigid , Rukmini Mien , Sulistiani Lies
Published: June 2021

Children who are in conflict with the law cannot be separated from the responsibilities of parents as the first party in the child's environment. The relationship between parents and children is a harmonized relationship from a strong emotional connection on the basis of blood relations. This situation makes parents unable to release and be released responsibility for their children's behavior. When children are faced with the law, policies to take over the responsibility of supervising children from parents, by denying that parents actually have the opportunity to deal with the problems of children who are dealing with the law are more often chosen. Even though the responsibility is transferred from the parents, they will find it difficult to rebuild the relationships they previously had with their children. This connection shows that parents also play a role when their children commit criminal acts indirectly
A conceptual framework for integrated management of Post-Natural Disasters Recovery (PNDR) projects
Authors: Bahmani Homa , Zhang Wei
Published: June 2021

Following the increasing rate of natural disasters, more attention is being paid to post-natural disaster reconstruction projects. However, from the perspective of project management, these projects show a significant degree of differences from the regular construction projects. Although some progress has been made on this topic, further research is needed to smooth pathways for the management of Post-Natural Disaster Recovery (PNDR) projects. This paper provides a management framework for PNDR projects throughout the qualitative analysis of the research's selected resources. The resources identified by applying inclusion and exclusion criteria in academic online platforms have been coded by NVivo 2020, and corresponding groups have been made for PNDR life-cycle and project stages. An integrated management framework has been put forward throughout the simultaneous application of the research's suggested life-cycle and project stages for PNDR projects. The most significant observation of this study is the necessity of applying a continuous life-cycle to address projects' long-term goals and provide an experience-based database for the management of next natural disasters. The significant role of planning in the entire life-cycle of PNDR projects, recognition of the tasks that need to be handled continuously during entire PNDR projects, the necessity of simultaneous consideration of tangible and intangible recovery outcomes are the other findings of this study. Recognition of reconstruction as part of the bigger system, named recovery, also stressed the necessity of considering the recovery project as a whole.
Southwestern ponderosa pine forest patterns following wildland fires managed for resource benefit differ from reference landscapes
Authors: Donager Jonathon James , Meador Andrew Joel Sánchez , Huffman David William
Published: June 2021

Context. Managers aiming to utilize wildland fire to restore southwestern ponderosa pine landscapes require better understanding of forest cover patterns produced at multiple scales. Restoration effectiveness of wildland fires managed for resource benefit can be evaluated against natural ranges of variation.Objectives. We describe landscape patterns within reference landscapes, including restored and functioning ponderosa pine forests of northern Arizona, and compare them to wildland fires managed for resource benefit. We make comparisons along a gradient of extents and assess the effects of scale on landscape differences.Methods. Using Sentinel-2 imagery, we classified ponderosa pine forest cover and calculated landscape metrics across a gradient of landscape extent within reference and managed landscapes. We used non-parametric tests to assess differences. We used random forest models to assess and explore which landscape metrics were most importance in differentiating landscape patterns.Results. Managed wildfire landscapes were significantly different from reference landscapes for most metrics and extents (15 ha to 840 ha). Landscape type (managed vs. reference) became increasingly differentiable with scale, with area and aggregation metrics being the most informative. Classification models increased in accuracy despite fewer observations with increasing scale.Conclusions. Wildland fires managed for resource benefit in ponderosa pine forests of northern Arizona are not producing landscape patterns consistent with reference landscapes likely due to predominance of low-severity burning and minimal resulting changes in overstory structure. Differences become more pronounced with increasing landscape size and suggest small-scale heterogeneity and mid - and large-scale homogeneity within each landscape type.
In vitro evaluation and molecular docking analysis of potential anticancer compounds from Annona muricata L.
Authors: Nalini Pichai , Ibrahim Kalibulla Syed , Brindha Durairaj
Published: June 2021

Annona muricata L. is widely distributed in tropical and subtropical regions around the world. Traditionally this plant has been used as a medicine for multiple ailments including cancer. The present study focussed on the anticancer activities of hydroethanolic extracts of leaves of A. muricata L. on Dalton’s Lymphoma Ascites (DLA) cell line in comparison with standard drug doxorubicin. Cytotoxicity studies have indicated that the phytoconstituents of A. muricata have the ability to selectively target cancer cells (IC50 = 185.585 µg/ml), whereas minimal or negligible cytotoxic effects were observed on normal cells. Gas Chromatography - Mass Spectrometry data revealed the presence of 16 phytoconstituents comprising mainly alkaloids and phenolic compounds. Pharmacokinetic profiling and molecular docking studies using the phytoconstituents were performed in order to gain a better understanding of the putative mechanisms of action leading to the development of improved and affordable therapies.
A virtual machine migration policy for multi-tier application in cloud computing based on game theory
Authors: Tran Hung Cong , Bui Khiet Thanh , Ho Hung Dac , Vu Vu Tran
Published: June 2021

Cloud computing technology provides shared computing which can be accessed over the Internet. When cloud data centers are flooded by end-users, how to efficiently manage virtual machines to balance both economical cost and ensure QoS becomes a mandatory work to service providers. Virtual machine migration feature brings a plenty of benefits to stakeholders such as cost, energy, performance, stability, availability. However, stakeholder's objectives are usually conflicted with each other. Also, the optimal resource allocation problem in cloud infrastructure is usually NP-Hard or NP-Complete class. In this paper, the virtual migration problem is formulated by applying game theory to ensure both load balance and resource utilization. The virtual machine migration algorithm, named V2PQL, is proposed based on Markov Decision Process and Q-learning algorithm. The results of the simulation demonstrate the efficiency of our proposal which are divided into training phase and extraction phase. The proposed V2PQL policy has been benchmarked to the Round-Robin policy in order to highlight their strength and feasibility in policy extraction phase.
Knowledge Vector Representation of Three Dimensional Convex Polyhedrons and Reconstruction of Medical Images using Knowledge Vector
Authors: Rani Shilpa , Lakhwani Kamlesh , Kumar Sandeep
Published: June 2021

Three-dimensional image construction and reconstruction play an important role in various applications of the real world in the field of computer vision. In the last three decades, researchers are continually working in this area because construction and reconstruction is an important approach in medical imaging. Reconstruction of the 3D image allows us to find the lesion information of the patients which could offer a new and accurate approach for the diagnosis of the disease and it adds a clinical value. Considering this, we proposed novel approaches for the construction and reconstruction of the image. First, the novel construction algorithm is used to extract the features from an image using syntactic pattern recognition. The proposed algorithm is able to extract in-depth features in all possible directions and planes and also able to represent the 3D image into a textual form. These features vector is nothing but a string that consists of direction and length information in syntactic form. For the identification of syntactic grammar, a real 3D clay model was made and identified the different possible patterns in the image. According to the domain knowledge, in a 3D image, a pixel could be present in 26 possible directions and we incorporated all possible directions in the proposed algorithm. In the same way, for the reconstruction of the image novel algorithm is proposed. In this algorithm, the knowledge vector has been taken as an input and the algorithm is able to reconstruct a 3D image. Reconstruction allows us to explore the internal details of the 3D images such as the size, shape, and structure of the object which could take us one step ahead in the field of medical image processing. Performances of the proposed algorithms are evaluated on five medical image dataset and the datasets are collected from Pentagram research institute, Hyderabad and results are outperformed in real-time. The accuracy of the proposed method is 94.78% and the average execution time is 6.76 seconds which is better than state of art methods.
Spotted Hyena Optimization and Simulated Annealing-based NLOS Nodes Localization Scheme for Improving Warning Message Dessimination in VANETs
Authors: S.B Lenin , Tamilarasan Narayana Samy
Published: June 2021

An accurate localization technique is considered as the significant entity in Vehicular Ad hoc Networks (VANETs) for facilitating emergency message data transmission in diversified critical safety applications. In VANETs, the system of global positioing is generally used for estimating the position of the vehicles in the network for attaining neighborhood awareness in the event of warning message dissemination. However, the existence of green foliages, buildings, indoor parking lots and urban streen canyons introduces NLOS situation that introduces unwanted errors that crumbles the degree of data dissemination in emergency situations. In this paper, Spotted Hyena and Simulated Annealing Optimization Algorithm (SHSAOA)-based positioning scheme was proposed for precise estimation of NLOS nodes. İt included the advantages of improved simulated annealing (SA) integrated into SHOA for establishing better balance between the process of exploitation and exploration in the search space. This positioning approach generated candidate solutions by deriving the merits of the trajectory-based charateristics of SA throughout the algorithmic development process in order to improve the local optimization process. This proposed SHSAOA utilized the distance infotmation that are associated with the vehicle trajectory, number of vehicles and error in distance information for assessing the precise location of the NLOS nodes in the network. The simulation results of the proposed SHSAOA scheme confirmed minimized localization error with maximized accuracy in transmission, warning message transmission rate, channel utilization degree and neighborhood awareness degree with different vehicular density and NLOS nodes.
Effects of High Flow Nasal Cannula on the Coordination between Swallowing and Breathing in Postextubation Patients, a Randomized Crossover Study
Authors: Rattanajiajaroen Pornpan , Kongpolprom Napplika
Published: June 2021

Background: Timing of swallows in relation to respiratory phases is associated with aspiration events. Oxygen therapy possibly affects the timing of swallows, which may alter airway protective mechanisms.Objectives: To compare the coordination between swallowing and respiration during water infusion in post-extubation patients using high flow nasal oxygen(HFNO) with the coordination in those using low flow nasal oxygen(LFNO).Methods: We conducted a randomized controlled crossover study in post-extubation patients. The patients extubated within 48 hours were randomly assigned into two groups, namely HFNO and LFNO. The eligible patients in each group received either HFNO with FiO2 35%, flow 50 LPM and temperature 34˚ C or LFNO 5 LPM for 5 minutes. The coordination between swallowing and respiration was observed during continuous infusion of 10 ml of water in one minute for three times. Respiratory phases and swallowing were monitored using ECG-derived respiratory signals and submental EMG, respectively. The swallowing frequency and timing of swallows in relation to respiratory phases were recorded. The coordination between swallowing and respiration was classified into 4 patterns, namely I ,E ,I-E and E-I swallows. (I; inspiration and E; expiration) Subsequently, after the 5 minute washout period, the patients were switched to receive the other type of oxygen therapy with the same procedure. Wilcoxon Signed Ranks Test was used for statistical analysis.Results: A total of 22 patients with the mean age of 55.8 years were enrolled into the study. The major indication for invasive mechanical ventilation was pneumonia with the median duration of endotracheal intubation of 2.5 days. The median of total swallowing numbers (three minutes) were 18.5 in the HFNO period and 21 in the LFNO period (p = 0.158). The most common swallowing pattern was E swallow. The patients using HFNO had higher numbers of E-swallow pattern (74.3% in HFNO vs 67.6% in LFNO; p = 0.048) and lower numbers of I-swallow pattern (14.3% in HFNO vs 23.1% in LFNO; p = 0.044). The numbers of other swallowing patterns were not different between 2 groups.Conclusions: Compared with LFNO, HFNO significantly increased the E-swallow and decreased the I- swallow in post-extubation patients. The findings indicated that HFNO might reduce the risk of aspiration during the post-extubation period.
Evaluation of Prediction Effect of Perfusion Index for Supraclavicular Brachial Plexus Block in Children
Authors: Wang Jinxu , Deng Lingli , Xu Aijun
Published: June 2021

Background: Pulse perfusion index (PI) is a reflection of blood perfusion. It has been reported that PI can be used to evaluate the effect of nerve block, but currently it is mostly focused on awake adults. In pediatric general anesthesia, it has been reported that PI can evaluate the effect of sacral block, but there is a lack of relevant research on the effect of brachial plexus blocks (BPB).Methods/Design: This is a mono-center, prospective, single-blinded, randomized controlled trial (RCT). 104 children aged 1 month to 12 years who undergo upper limb surgery will be enrolled in this study. According to anesthesia induction and maintenance medication, they will be divided into propofol group and sevoflurane group. Record the PI values of the index finger and little finger on the blocked and non-blocked sides of supraclavicular brachial plexus block (SCB) in all children. First, analyze the two groups of patients with complete blockage respectively, and observe whether the PI values of the index finger and the little finger have the same changes by comparing the baseline values. Secondly, the cases of failed or partial block will be analyzed to understand the relationship between the PI values of the index and little fingers. Thirdly, a comparative analysis of nerve block cases in the sevoflurane and propofol groups will find that PI in what kind of general anesthesia can better judge the effect of SCB in children. So as to provide a theoretical basis for PI to estimate the effect of SCB under general anesthesia in children.Discussion: After sevoflurane or propofol administration, changes in PI after BPB may exist in different situations at different periods. PI values in the blocked and non-blocked sides may vary with the metabolism of anesthetics. The surgery time is about 1h or so and the effects of nerve block still exist, so the PI value changes on the blocking side and the contralateral side can basically rule out the influence of general anesthetics on the PI value. Trial registration: ClinicalTrials.gov NCT04216823. Registered on 15 July, 2020.
Radiomics Methods to Differentiate Metastasis and Primary Lung Cancer of Breast Cancer Patients in PET/CT
Authors: Zhou Xinglu , Peng Yunsong , Li Yingci , Zhang Jiarui , Liu Tianyi , Jiang Huijie , Zheng Jian
Published: June 2021

Purpose：Positron emission tomography (PET) with integrated computed tomography (PET/CT) is a whole-body imaging method providing information the entire body. When it was used in staging breast cancer patients, quite a few patients were found to have a second primary lung cancer(PLC), which was has few distinguishing features from breast cancer metastasis(MBC). Therefore, based on CT, LDCT and PET images, combined with pathological features, we established radiomics models to distinguish between MBC and PLC.Methods：We retrospectively collected CT, LDCT, and PET images, and pathology features of 100 breast cancer patients, including 60 metastases of breast cancer(MBC) and 40 primary lung cancers(PLC). The two radiologists manually drew a region of interest around the whole visible tumor in consensus. Python 3.8 and Pyradiomics toolkit are used to extract features from CT, LDCT, and PET. The linear discriminant analysis (LDA) classifier was used to build the radiomics model. The receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to evaluate the classification performance.Results：Total 12, 13, and 9 features were selected from the CT, LDCT, and PET respectively. The model based on the LDCT and PET obtained the same highest AUC (0.9479). The combination with CT and pathology features showed a highest AUC of 0.9583 with a sensitivity of 1.000 and a specificity of 0.8333. Conclusion：Overall, the results are encouraging that radiomics models based on CT, LDCT and PET can differentiate between MBC and PLC pathological features could significantly improve the AUC and ACC of CT model.
Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature
Authors: Muñoz-Ortiz Juliana , Charry-Sánchez Jesús David , Bechara-Arango Isabella , Blanco-Becerra Mariana , Talero-Gutiérrez Claudia , Gomez-Suarez Marcela , de-la-Torre Alejandra
Published: June 2021

Background: Down syndrome (DS) is a chromosomal anomaly that is characterized by an extra chromosome 21. Ophthalmological manifestations have a high prevalence in patients with DS.Purpose: To review the scientific evidence and estimate the prevalence of ophthalmological manifestations in the pediatric population with DS.Data Sources: Electronic databases including MEDLINE, Cochrane Library, EMBASE, ScienceDirect, and LILACS.Study Eligibility Criteria: Published observational studies with available and original data were included. Articles were excluded if the study design was a review, letter to the editor, case report, case series, or systematic review and if the subjects had ophthalmological manifestations secondary to other conditions.Participants and Interventions: Pediatric and adolescent population with DS and with ophthalmological evaluation.Study Appraisal and Synthesis Methods: A data collection form was designed in Excel. Five reviewers extracted relevant details about the design and results of each study. The quality of the studies was assessed by applying the tools of systematic reviews of prevalence and incidence of the Joanna Briggs Institute. We calculated the weighted prevalence of ophthalmological manifestations, considering only the studies reporting the measurement of each manifestation.Results: Twenty-two articles (from 15 countries, published during 1994–2020) were included in the present systematic review. Ocular manifestations were observed in 85% of the studied pediatric and adolescent populations with DS. The most frequent ones were slanting fissures, oblique fissures, epicanthus, and epiblepharon.Conclusion: The ocular manifestations in the pediatric and adolescent population with DS are varied, and some can irreversibly affect visual development. Screening of the pediatric population with DS should be conducted from the first months of age and continued annually.Systematic Review Registration Number: PROSPERO ID CRD42019127717
Handwashing Adherence and the Trajectory of COVID-19 Pandemic: Findings from 14 Countries
Authors: Szczuka Zofia , Abraham Charles , Baban Adriana , Brooks Sydney , Cipolletta Sabrina , Danso Ebrima , Dombrowski Stephan U. , Gan Yiqun , Gaspar Tania , Matos Margarida Gaspar , Griva Konstadina , Jongenelis Michelle , Keller Jan , Miah Mohammad Abdul Awal , Morgan Karen , Peraud William , Quintard Bruno , Shah Vishna , Schenkel Konstantin , Scholz Urte , Schwarzer Ralf , Siwa Maria , Szymanski Kamil , Taut Diana , Tomaino Silvia C. M. , Vilchinsky Noa , Wolf Hodaya , Luszczynska Aleksandra , Ma Jinjin , Knoll Nina
Published: June 2021

Background: The COVID-19 pandemic has affected people’s engagement in health behaviors, especially those that protect individuals from SARS-CoV-2 transmission, such as handwashing/sanitizing. Associations between the pandemic’s trajectory and engagement in the protective behavior of handwashing are unclear. This study investigated whether adherence to the World Health Organization’s (WHO) handwashing guidelines is associated with (i) total cases of COVID-19 morbidity/mortality accumulated since the onset of the pandemic, (ii) recent cases (country-level COVID-19 morbidity/mortality in the 14 days prior to data collection), (iii) increases/acceleration in recent cases (country-level COVID-19 morbidity/mortality in the previous 14 days minus cases recorded 14-28 days earlier), and (iv) stringency of the national containment-and-health policies (in the 7 days prior to data collection).Methods: The observational study (#NCT04367337) enrolled 6,064 adults residing in Australia, Canada, China, France, Gambia, Germany, Israel, Italy, Malaysia, Poland, Portugal, Romania, Singapore, and Switzerland. Data on cross-situational handwashing adherence were collected via an online survey (March–July 2020). Individual data were matched with the WHO daily reports of COVID-19 and indices of containment-and-health policies. Country-level human development index and sociodemographic variables were controlled.Results: Multilevel regression models indicated that as the total cases of COVID-19 morbidity and mortality grew higher, handwashing adherence decreased. As increases in recent cases of COVID-19 morbidity and mortality occurred, handwashing adherence increased. Higher levels of containment-and-health policy index were associated with lower handwashing.Conclusions: Research investigating protective behaviors should account for indicators of fluctuations of COVID-19 morbidity/mortality, besides accounting for time since the beginning of the pandemic.Trial Registration: Clinical Trials.Gov, #NCT04367337, first registration date: 29/04/2020
A New Sight In The Key Prognosis-Related Proto-Oncogene FYN In Hepatocellular Carcinoma Based On WCGNA Hub-Gene Screening Strategy
Authors: Huang Chenkai , Zhou Juanjuan , Nie Yuan , Guo Guihai , Wang Anjiang , Zhu Xuan
Published: June 2021

Background: Hepatocellular Carcinoma (HCC) is the third deadly cancer worldwide. More breakthroughs are needed in the clinical practice of liver cancer, and new treatment strategies are required to carry out to benefit patients. This study aims to screen out other significant differences in genes associated with LIHC and analyze its prognostic value further. Methods: Here, we use the TCGA-LIHC database and the profiles of GSE25097 from GEO to explore the differential co-expression genes in HCC tissues compared with para-tumor (or healthy) tissues. Then, we utilized WGCNA to screen out differential co-expression genes. Finally, we explored the function of FYN in HCC cells and xenograft tumor models.Results: We identified ten hub genes in the protein-protein interaction (PPI) network, but only three (COLEC10, TGFBR3, and FYN) of them seem to have a close-related to the prognosis. The expression of FYN was negatively correlated with the prognosis of HCC patients. The xenograft model showed that overexpression of FYN could significantly inhibit malignant tumor behaviors and promote tumor cell apoptosis.Conclusion: Thus, FYN may be central to the development of LIHC and maybe a novel biomarker for clinical diagnosis and treatment.
Development and Validation of a One-Step RT-qPCR Assay for Identifying Common Fusion Gene Transcripts Associated with the Prognosis of Mexican Children with B-Lineage Acute Lymphoblastic Leukemia
Authors: Mejía-Aranguré Juan Manuel , Mata-Rocha Minerva , Rangel-López Angelica , Núñez-Enríquez Juan Carlos , Jiménez-Hernández Elva , Morales-Castillo Blanca Angélica , Sánchez-Escobar Norberto , Sepúlveda-Robles Omar Alejandro , Bravata-Alcántara Juan Carlos , Nájera-Cortés Alan Steve , Pérez-Saldivar María Luisa , Flores-Lujano Janet , Duarte-Rodríguez David Aldebarán , de Anda Norma Angélica Oviedo , Verson Carmen Alaez , Martín-Trejo Jorge Alfonso , Campo-Martínez María de Los Ángeles Del , Muñoz-Medina José Esteban , González-Bonilla César Raúl , Cueto Maria de los Angeles Hernandez , Medina-Sansón Aurora , Amador-Sánchez Raquel , Peñaloza-González José Gabriel , Torres-Nava José Refugio , Espinosa-Elizondo Rosa Martha , Cortés-Herrera Beatriz , Flores-Villegas Luz Victoria , Merino-Pasaye Laura Elizabeth , Solís-Labastida Karina Anastacia , Velázquez-Aviña Martha Margarita , Santillán-Juárez Jessica Denisse , Gurrola-Silva Alma , García-Velázquez Alejandra Jimena , Echáurregui Gabriela Alicia Hernández , Rosas-Vargas Haydeé
Published: June 2021

The aims of the present study were to optimize the detection of common fusion gene transcripts associated with childhood B-ALL prognosis through the development and validation of a one-step RT-qPCR assay and to identify the prevalence of these genes in a cohort of pediatric patients attended in public hospitals in Mexico City. The one-step RT-qPCR assay was sensitive, specific, easy to use, fast and cost efficient. The standard curves were linear, with amplification efficiencies between 97-107%; coefficients of variation were 2.1-3.0% in reproducibility and 2.6-3.8% in repeatability, with agreement between two different laboratories. The prevalence of fusion gene transcripts was ETV6-RUNX1, 10.3%; TCF3-PBX1, 7.5%; BCR-ABL1p190, 3.6%; and KMT2A-AFF1, 2.8%. The prevalence of the ETV6-RUNX1 fusion was low, consistent with the findings in Hispanics. The KMT2A-AFF1 fusion was not exclusively present in infants, as we also found it in patients 4-16 years of age, in whom it was related to a poor prognosis. TCF3-PBX1 patients were associated with an intermediate outcome. The present study highlights the importance of the detection of common genetic fusions in Mexican children with ALL, taking into account that some have molecular subtypes associated with a poor prognosis.
Research on a Dynamic Equilibrium Mechanism of Core Layer Interests in the Mobile Medical Platform Business Ecosystem
Authors: Shenghua Zheng , Shijie Wang , Jue Chen
Published: June 2021

In recent years, with the development of the mobile Internet, big data and cloud computing, by aggregating platform ecological resources, mobile medical platforms such as the one operated by Ding Xiang Yuan have played an irreplaceable role in improving efficiency, optimizing resource allocation and promoting the transformation and upgrading of the medical industry. Despite this, most of the domestic mobile medical platforms in China still experience problems, such as an immature business model, stagnation of the interaction of knowledge and information among platform members, and weak platform competitiveness. Based on a review of platform and commercial ecosystems, this paper, by using the evolutionary game method and simulation, analyses the evolutionary stability strategy of operators, partners and users in the core layer of the platform during pre-flow and post-flow periods of a mobile medical platform; this study thereby constructs a benefit dynamic equilibrium model of a platform business ecosystem under the optimal decisions made by all parties involved in the platform. The research helps reveal the inherent law of the development of mobile medical platforms and provides recommendations for policy-making and strategy formulation in building an appropriate business ecosystem and achieving sustainable development in mobile medical platforms.
Optimal Load Balancing in Cloud using ANFIS and MGWO based Polynomial Neural Network
Authors: Chourasia Uday , Silakari Sanjay
Published: June 2021

In recent years, cloud computing provides a spectacular platform for numerous users with persistent and alternative varying requirements. Here providing an appropriate service is considered a major challenge in the heterogeneous environment. In the cloud environment, security and service availability are the two most significant factors during the data encryption process. In order to provide optimal service availability, it is necessary to establish a load balancing technique that is capable of balancing the request from diverse nodes present in the cloud. This paper aims in establishing a dynamic load balancing technique using the APMG approach. Here in this paper, we integrated adaptive neuro-fuzzy interference system-polynomial neural network as well as memory-based grey wolf optimization algorithm for optimal load balancing. The memory-based grey wolf optimization algorithm is employed to enhance the precision of ANFIS-PNN and to maximize the locations of the membership functions respectively. In addition to this, two significant factors namely the turnaround time and CPU utilization involved in optimal load balancing scheme are evaluated. In addition to this, the performance evaluation of the proposed MG-ANFIS based dynamic load balancing approach is compared with various other load balancing approaches to determine the system performances.
Phase II Feasibility Study of Adjuvant Chemotherapy With Docetaxel/Cisplatin/S-1 Followed By S-1 For Stage III Gastric Cancer
Authors: Hirahara Noriyuki , Matsubara Takeshi , Kaji Shunsuke , Yamamoto Tetsu , Hyakudomi Ryoji , Takai Kiyoe , Ishitobi Kazunari , Uchida Yuki , Tajima Yoshitsugu
Published: June 2021

BackgroundTo evaluate the feasibility, safety, and efficacy of postoperative adjuvant chemotherapy with docetaxel/cisplatin/S-1 (DCS) following S-1 therapy in patients with stage III gastric cancer after curative gastrectomy.Methods Patients with stage III gastric cancer who underwent D2 gastrectomy were enrolled. Adjuvant chemotherapy was initiated within 8 weeks of gastrectomy. The first cycle of chemotherapy consisted of S-1 monotherapy (day 1–14), followed by a 7-day rest period. Cycles 2 and 3 consisted of the following: S-1 (day 1–14) administration, followed by a 14-day rest period, and an intravenous infusion of cisplatin and docetaxel on days 1 and 15. After 2 cycles, S-1 was administered for up to 1 year.Results Thirty patients were enrolled between 2013 and 2017. Febrile neutropenia of grade 3 or higher was the most common hematological toxicity with 4 patients (13.3%). Other hematological toxicities of grade 3 or higher were as follows: neutropenia in 3 (10.0%), leukopenia in 3 (10.0%), and anemia in 2 (6.7%). Most frequent non-hematological toxicity of grade 3 was anorexia (n=4, 13.3%) and general fatigue (n=3, 10.0%); no grade 4 non-hematological toxicities were observed. Twenty-five patients (83.3%) completed 2 cycles of DCS treatment and 18 (60.0%) completed subsequent S-1 treatment for 1 year. The relative dose intensity of docetaxel and cisplatin was 0.86 and that of S-1 was 0.88. Conclusion The DCS regimen can be acceptable as an adjuvant chemotherapy and offers an effective postoperative treatment option for stage III gastric cancer patients.Trial registration number: UMIN000012785 Date of registry: 08/01/2014
The Effect of Transactional Analysis Training On Emotional Intelligence In Health Professions Students
Authors: Yean Seow Hui , Wu Mabel Huey Lu , Mohan Mandakini , Mamat Norul Hidayah binti , Kutzsche Hildegunn Ellinor , Pau Allan Kah Heng
Published: June 2021

BackgroundWe evaluated the effect of psycho-educational training in emotional intelligence (EI) and transactional analysis (TA) (TEITA) on EI in health professions undergraduates, post-training and at 1-month follow-up. MethodsA total of 34 participants participated in the study where 17 participants were in TEITA group and another 17 were in control group. A quasi-experimental nonrandomised, controlled cohort was conducted, in which participants in TEITA group were introduced to EI and TA concepts on a weekly basis for four weeks, at 90 minutes each time, and provided with opportunities for experiential sharing of emotions and coping mechanisms experienced in the previous week. Both TEITA and control groups received weekly EI and TA reading materials. All completed the 16-item Wong and Law EI Scale at baseline and post-training. Training group also completed the questionnaire at 1-month follow-up. Wilcoxon Signed Ranks and Mann Whitney tests were used to analyse within group and between group changes in EI scores. ResultsBaseline EI scores in TEITA group were lower than control group. On completion of TEITA, EI scores in TEITA group increased, and differences were not detected between groups. Within TEITA group, paired increases in all domains were statistically significant, whereas in the control group, paired increase was only detected in the domain addressing regulations of emotion (ROE). Pre to post-training increases in EI scores were statically significantly greater in TEITA compared to control groups. At the 1-month follow-up, EI were sustained. ConclusionThe psycho-educational training based on EI and TA is effective in enhancing EI in health professions students. Future research should investigate the effect of such training on observable inter-personal and socio-economic behaviours.
The Complete Chloroplast Genome and Characteristics Analysis of Musa basjoo Siebold
Authors: Liu Fenxiang , Movahedi Ali , Yang Wenguo , Xu Dezhi , Jiang Chuanbei , Xie Jigang , Zhang Yu
Published: June 2021

Musa basjoo Siebold is an ornamental plant often seen in gardens and farmhouses. It can also be used as a kind of Chinese herbal medicine. The decoct soup of its pseudo stem can help relieve the heat. Its pseudo stem and leaves are diuretic. The decoct soup of its dried flower can treat cerebral hemorrhage. Its root can be decocted together with ginger and licorice to cure gonorrhea and diabetes. The chloroplast genome study on Musa basjoo Siebold is rarely seen. This paper showed that the length of the chloroplast genome Musa basjoo Siebold was 172,322 bp, with 36.45% GC content. Musa basjoo Siebold included a large single-copy region of 90,160 bp, a small single-copy region of 11,668 bp, and a pair of inverted repeats of 35,247 bp. Comparing the genomic structure and sequence data of closely related species, we revealed the conserved gene order of the IR and LSC/SSC regions, which provided a very inspiring discovery for future phylogenetic research. Overall, this study is the first time an evolutionary tree of the genus Musa species has been constructed with the complete chloroplast genome sequence. We can see that there is no obvious multi-branching in the genus, and Musa basjoo Siebold, and Musa itinerans are the closest relatives.