bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between delayed invasive blood pressure monitoring and all-cause mortality in intensive care unit patients with sepsis: a retrospective cohort study
Authors: Xiao Li , Shen Pu , Han Xue , Yu Yi
Published: November 2024

Purpose

Haemodynamic management is essential in sepsis management. Invasive blood pressure (IBP) monitoring is the gold standard for blood pressure (BP) assessment. Here, we identified the most advantageous time frame for IBP monitoring to mitigate adverse outcomes in patients with sepsis.

Methods

We included data on patients with sepsis from the Medical Information Mart for Intensive Care IV database. The primary endpoints comprised 28-and 90-day mortality rates, whereas secondary endpoints were acute kidney injury (AKI) rates and continuous renal replacement therapy (CRRT) requirement. To confirm our findings’ robustness, we performed multivariable Cox regression and logistic regression models, augmented by propensity score matching (PSM).

Results

Of 18,326 patients hospitalised for sepsis, 9,056 (49.42%) and 9,270 (50.58%) were included in the early and delayed IBP-monitoring groups, respectively. Our multivariable Cox regression models revealed 20 and 21% significant increases in 28-and 90-day mortality in the delayed IBP monitoring group, respectively [hazard ratios (95% confidence intervals) = 1.20 (1.11–1.31) and 1.21 (1.12–1.31), respectively; both p < 0.001]. Moreover, significant increases were noted in AKI, CRRT and mechanical ventilation requirement risks in the delayed IBP monitoring group [odds ratios (95% confidence intervals) = 1.44 (1.34–1.56), 1.50 (1.26–1.78) and 1.79 (1.67–1.92), respectively; both p < 0.001]. PSM further confirmed the validity of our findings. Delayed IBP monitoring prolonged intensive care unit (ICU) stay without extending vasopressor use duration.

Conclusion

Prolonged delay in IBP monitoring (≥3 h) may increase mortality risks in ICU patients with sepsis. Nevertheless, early IBP monitoring may reduce AKI, CRRT and mechanical ventilation requirement risks and shorten ICU stay. However, these results warrant further validation through randomised controlled trials.
α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality
Authors: Yatomi Taisuke , Tomasi Dardo , Tani Hideaki , Nakajima Shinichiro , Tsugawa Sakiko , Nagai Nobuhiro , Koizumi Teruki , Nakajima Waki , Hatano Mai , Uchida Hiroyuki , Takahashi Takuya
Published: November 2024

Local and global functional connectivity densities (lFCD and gFCD, respectively), derived from functional magnetic resonance imaging (fMRI) data, represent the degree of functional centrality within local and global brain networks. While these methods are well-established for mapping brain connectivity, the molecular and synaptic foundations of these connectivity patterns remain unclear. Glutamate, the principal excitatory neurotransmitter in the brain, plays a key role in these processes. Among its receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is crucial for neurotransmission, particularly in cognitive functions such as learning and memory. This study aimed to examine the association of the AMPAR density and FCD metrics of intraregional and interregional functional centrality. Using [11C]K-2, a positron emission tomography (PET) tracer specific for AMPARs, we measured AMPAR density in the brains of 35 healthy participants. Our findings revealed a strong positive correlation between AMPAR density and both lFCD and gFCD-lFCD across the entire brain. This correlation was especially notable in key regions such as the anterior cingulate cortex, posterior cingulate cortex, pre-subgenual frontal cortex, Default Mode Network, and Visual Network. These results highlight that postsynaptic AMPARs significantly contribute to both local and global functional connectivity in the brain, particularly in network hub regions. This study provides valuable insights into the molecular and synaptic underpinnings of brain functional connectomes.
Masculinities in a feminist pedagogy: lessons for transformative gender and agriculture training
Authors: Mwiine Amon Ashaba , Mangheni Margaret Najjingo , Asiimwe Elizabeth , Businge Martha , Shimali Fred , Sanya Losira Nasirumbi
Published: November 2024

Masculinities and femininities are closely interconnected with men and women farmers’ everyday lives; hence critical reflection on these interconnections should be central in gender training in agriculture. While a focus on men and masculinities is crucial for sustainable transformation of deep-rooted gender norms and practices that limit the attainment of gender equality, there are insufficient empirically tested pedagogical models for this purpose. We share a case study, the Gender Responsive Researchers Equipped for Agricultural Transformation (GREAT) model, which incorporates masculinities in a feminist pedagogy. We use external monitoring, evaluation, and learning data for two case study courses that integrate gender in plant breeding, seed systems, and agronomy to demonstrate the efficacy of integrating the concept of masculinity and reflections on male farmers’ expectations, behaviors, and practices within a feminist approach to gender training. We conclude that feminist pedagogical practices offer insights into how gender training can integrate a masculinities perspective to move beyond divisive and narrow gender polarities towards addressing masculine norms that often hinder the attainment of gender transformation.
Beneficial Impact of Vaccination Against SARS-CoV-2 on the Mental Health of IPF Patients
Authors: Tomos Ioannis , Papaioannou Andriana I. , Daniil Zoe I. , Dimeas Ilias E. , Kirgou Paraskevi , Gogali Athena , Tatsis Konstantinos , Papanikolaou Ilias , Tzilas Vasilios , Tzouvelekis Argyrios , Tsiri Panayiota , Steiropoulos Paschalis , Ntolios Pachalis , Xyfteri Areti , Antoniou Katerina , Symvoulakis Emmanouil , Haritou Aggeliki , Maniati Maria , Kolilekas Lykourgos , Antonogiannaki Elvira-Markella , Apollonatou Vasiliki , Kallieri Maria , Samaras Kostas , Loukides Stylianos , Karakatsani Anna , Bouros Demosthenes , Manali Effrosyni , Papiris Spyros
Published: November 2024

Background: Depression and anxiety represent significant comorbidities in idiopathic pulmonary fibrosis (IPF) patients, affecting their quality of life. The COVID-19 pandemic has had an uneven impact on global mental health. The Hospital Anxiety and Depression Scale (HADS) constitutes a validated tool to identify anxiety disorders and depression. The aim of this multicentre study was to evaluate the effect of COVID-19 vaccination on depression and anxiety in IPF patients. Methods: Consecutive IPF patients (median 73.5 years) who are regularly followed-up with were included in the study. Demographics, functional, and clinical were recorded. The HADS score was calculated before and one month after vaccination against COVID-19 in all participants. A Wilcoxon signed ranks test was conducted. Results: A total of 180 IPF patients (median 73.5 years) were included in the study. Among them, 145 patients (81%) received antifibrotic treatment. A significant reduction in HADS, both in anxiety and depression scales, was observed one month after vaccination against SARS-COV-2), independent of age, smoking, lung function impairment, and prior history of depression (p < 0.01). Conclusions: A higher Hospital Anxiety and Depression Scale score was detected before vaccination against COVID-19. It seems that vaccination also offered a beneficial effect on depression and anxiety in IPF patients, independent of age, smoking, lung function impairment, and prior history of depression.
The Origins of Engineered Biomaterials: NSF-Funded, University of Washington Engineered Biomaterials (UWEB)
Authors: Ratner Buddy D.
Published: November 2024

The University of Washington Engineered Biomaterials (UWEB) Engineering Research Center (ERC) was funded from 1996 to 2007 by the U.S. National Science Foundation. The mission of UWEB was to advance biomaterials by integrating modern biology with materials science. UWEB specifically focused on the healing and integration of medical implants. UWEB teamed biologists, physicians, engineers, and industry and demonstrated three paths that might advance biomaterials so they could seamlessly integrate and heal in the body. The three primary lines of investigation were precision porous scaffolds, super-non-fouling surfaces, and the control of matricellular proteins. The UWEB program set the groundwork for the modern field of immunoengineering. Also, UWEB invested significantly in training scientists/engineers who could freely integrate advances in biological sciences, state-of-the-art materials science, and medical technology. This historical summary of the UWEB program demonstrates that federal investment in interfacing forefront fields can yield dividends with benefits for society and the economy.
Unbiased Method to Determine Articular Cartilage Thickness Using a Three-Dimensional Model Derived from Laser Scanning: Demonstration on the Distal Femur
Authors: Campanelli Valentina , Hull Maury L.
Published: November 2024

Measuring articular cartilage thickness from 3D models developed from laser scans has the potential to offer high accuracy. However, this potential has not been fulfilled, since generating these models requires that the cartilage be removed, and previous methods of removal have led to systematic errors (i.e., bias) due to changes in the overall dimensions of the underlying bone. The objectives were to present a new method for removing articular cartilage, quantify the bias error, and demonstrate the method on the distal (i.e., 0° flexion) and posterior (i.e., 90° flexion) articular surfaces of example human femurs. The method consisted of creating a 3D articular cartilage model from high-accuracy (i.e., precision = 0.087 mm) laser scans before and after cartilage removal using dermestid beetles to remove the cartilage. Fiducial markers were used to minimize errors in registering surfaces generated from the two laser scans. To demonstrate the method, the cartilage thickness was computed in distal and posterior subregions of each femoral condyle for three example cadaveric specimens. The use of dermestid beetles did not introduce measurable bias, and the previously reported precision achieved in 3D cartilage models with the laser scanner was 0.13 mm. For the different subregions, the cartilage thickness ranged from 1.5 mm to 2.0 mm. A method of imaging by means of laser scanning, cartilage removal by means of dermestid beetles, and 3D model registration by means of fiducial markers ensured that cartilage thickness on the articular surface of the long bones of the knee was determined with negligible bias and a precision of 0.13 mm. With this method, the potential to measure cartilage thickness with high accuracy based on 3D models developed from laser scans can be fully realized.
Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
Authors: Lucia Umberto , Grisolia Giulia , Ponzetto Antonio , Deisboeck Thomas S.
Published: November 2024

Background: Inflammation is caused by an excess of Sodium ions inside the cell. This generates a variation in the cell’s membrane electric potential, becoming a steady state from a thermodynamic viewpoint. Methods: This paper introduces a thermodynamic approach to inflammation based on the fundamental role of the electric potential of the cell membrane, introducing an analysis of the effect of heat transfer related to the inflammation condition. Results: The direct proportionality between the reduction in temperature and the increase of Na+ outflow may ameliorate the inflammation cascade. Conclusions: Based on these ion fluxes, we suggest the consideration of a ‘companion’ electromagnetic therapeutic wave concept in support of the present anti-inflammatory treatment.
Magnesium Membrane Shield Technique for Alveolar Ridge Preservation: Step-by-Step Representative Case Report of Buccal Bone Wall Dehiscence with Clinical and Histological Evaluations
Authors: Blašković Marko , Butorac Prpić Ivana , Aslan Serhat , Gabrić Dragana , Blašković Dorotea , Cvijanović Peloza Olga , Čandrlić Marija , Perić Kačarević Željka
Published: November 2024

Background/Objectives: Despite the increased use of new resorbable magnesium membranes, there are no reported cases or studies on the use of resorbable magnesium membranes in combination with bone grafts for alveolar ridge preservation (ARP) in cases with severe buccal bone wall dehiscence. This case report aimed to evaluate the effectiveness of the magnesium membrane shield technique in conjunction with bone grafting for ARP, assessing both clinical outcomes and histological bone regeneration. Methods: A 44-year-old female patient presented with a vertical fracture on tooth 24 (FDI Notation System) accompanied with complete destruction of the buccal bone wall. The treatment plan included tooth extraction, ARP using a combination of anorganic bovine bone and autologous bone grafting, and the application of a magnesium membrane as a shield to the pre-existing buccal wall. Six months post-procedure, a bone biopsy was taken from the implant site using a trephine bur. Results: Clinical and radiological evaluations six months after the procedure demonstrated sufficient bone volume for implant placement. Additionally, in the next three months, soft tissue conditioning with a provisional crown resulted in an aesthetically and functionally satisfactory outcome. Histological analysis of the bone biopsy revealed well-formed new bone in direct contact with residual biomaterial, with no signs of inflammation. Osteocytes were clearly visible within the newly formed bone matrix, indicating successful bone maturation. Active osteoblasts were observed along the bone-biomaterial interface, suggesting ongoing bone remodeling and integration. Additionally, histomorphometric evaluation revealed 47% newly formed bone, 32% soft tissue, and 19% residual biomaterial. Conclusions: This case demonstrates the potential of the magnesium shield technique as an ARP technique in cases with severe buccal wall dehiscence. The technique yielded satisfactory clinical outcomes and promoted successful bone regeneration, as confirmed by histological analysis.
Re-Examination of the Sel’kov Model of Glycolysis and Its Symmetry-Breaking Instability Due to the Impact of Diffusion with Implications for Cancer Imitation Caused by the Warburg Effect
Authors: Satarić Miljko V. , Nemeš Tomas , Tuszynski Jack A.
Published: November 2024

We revisit the seminal model of glycolysis first proposed by Sel’kov more than fifty years ago. We investigate the onset of instabilities in biological systems described by the Sel’kov model in order to determine the conditions of the model parameters that lead to bifurcations. We analyze the glycolysis reaction under the circumstances when the diffusivity of both ATP and ADP reactants are taken into account. We estimate the critical value of the model’s single compact dimensionless parameter, which is responsible for the onset of reaction instability and the system’s symmetry breaking. It appears that it leads to spatial inhomogeneities of reactants, leading to the formation of standing waves instead of a homogeneous distribution of ATP molecules. The consequences of this model and its results are discussed in the context of the Warburg effect, which signifies a transition from oxidative phosphorylation to glycolysis that is correlated with the initiation and progression of cancer. Our analysis may lead to the selection of therapeutic interventions in order to prevent the symmetry-breaking phenomenon described in our work.
Benchmark Investigation of SARS-CoV-2 Mutants’ Immune Escape with 2B04 Murine Antibody: A Step Towards Unraveling a Larger Picture
Authors: Kapusta Karina , McGowan Allyson , Banerjee Santanu , Wang Jing , Kolodziejczyk Wojciech , Leszczynski Jerzy
Published: November 2024

Even though COVID-19 is no longer the primary focus of the global scientific community, its high mutation rate (nearly 30 substitutions per year) poses a threat of a potential comeback. Effective vaccines have been developed and administered to the population, ending the pandemic. Nonetheless, reinfection by newly emerging subvariants, particularly the latest JN.1 strain, remains common. The rapid mutation of this virus demands a fast response from the scientific community in case of an emergency. While the immune escape of earlier variants was extensively investigated, one still needs a comprehensive understanding of how specific mutations, especially in the newest subvariants, influence the antigenic escape of the pathogen. Here, we tested comprehensive in silico approaches to identify methods for fast and accurate prediction of antibody neutralization by various mutants. As a benchmark, we modeled the complexes of the murine antibody 2B04, which neutralizes infection by preventing the SARS-CoV-2 spike glycoprotein’s association with angiotensin-converting enzyme (ACE2). Complexes with the wild-type, B.1.1.7 Alpha, and B.1.427/429 Epsilon SARS-CoV-2 variants were used as positive controls, while complexes with the B.1.351 Beta, P.1 Gamma, B.1.617.2 Delta, B.1.617.1 Kappa, BA.1 Omicron, and the newest JN.1 Omicron variants were used as decoys. Three essentially different algorithms were employed: forced placement based on a template, followed by two steps of extended molecular dynamics simulations; protein–protein docking utilizing PIPER (an FFT-based method extended for use with pairwise interaction potentials); and the AlphaFold 3.0 model for complex structure prediction. Homology modeling was used to assess the 3D structure of the newly emerged JN.1 Omicron subvariant, whose crystallographic structure is not yet available in the Protein Database. After a careful comparison of these three approaches, we were able to identify the pros and cons of each method. Protein–protein docking yielded two false-positive results, while manual placement reinforced by molecular dynamics produced one false positive and one false negative. In contrast, AlphaFold resulted in only one doubtful result and a higher overall accuracy-to-time ratio. The reasons for inaccuracies and potential pitfalls of various approaches are carefully explained. In addition to a comparative analysis of methods, some mechanisms of immune escape are elucidated herein. This provides a critical foundation for improving the predictive accuracy of vaccine efficacy against new viral subvariants, introducing accurate methodologies, and pinpointing potential challenges.
Assessment of Pudding Formulations Using Lyophilized Apricot, Plum, and Plum–Apricot Powders: Texture, Bioactivity, and Sensory Quality
Authors: Popova Aneta , Doykina Pavlina , Mihaylova Dasha , Dimitrova-Dimova Maria
Published: November 2024

The food sector is constantly responding to consumers’ increased demands concerning healthy nutrition and beneficial ingredients. This study presented the development of three pudding alterations using lyophilized fruit (apricots, plum–apricots, and plums) powders. The same concentrations of fruit powder fully substituted the sugar in each formulation. The results showed that each new formulation formed a thick gel consistency and had full water-holding capacity at 24 h of storage. The color differed according to the established CIE-lab data. The lightness varied from 42.57 ± 1.97 (pudding formulation using plum powder) to 81.91 ± 1.18 (control sample). The total soluble solids and titratable acidity showed that the control sample was different from each new formulation. The water activity was similar in all studied samples varying from 0.978 ± 0.003 to 0.989 ± 0.001, and the plum and plum–apricot formulations had a pH near the control samples, at 6.54 and 7.23, respectively. The antioxidant activity, total polyphenol content, and total flavonoid content were also evaluated. The ABTS assay revealed the highest results compared to the other three applied methods. The sensory evaluation showed that it is necessary to further improve the recipes for better consumer perception.
Effect of Dietary Olive Leaf Integration on Qualitative Characteristics of Sheep Cheese During Ripening
Authors: Contò Michela , Rinaldi Simona , Contò Giacomo , Sagrafoli Daniele , Boselli Carlo , Giacinti Giuseppina , Failla Sebastiana
Published: November 2024

Olive leaf by-products may be an important feed source for ruminants in the Mediterranean area, due to their nutritional value and high levels of functional metabolites. Additionally, their use can enhance the environmental and economic sustainability of the productions. To evaluate the effect of olive leaf supplementation on the fatty acid profile of sheep cheese, two farms with Comisana breed sheep with free access to pasture and fedwith 300 g/head/day of concentrate were considered. One farm supplemented the feed with clover hay ad libitum (NOL) and the other farm replaced hay with olive leaves (OLI) in the autumn period. Cheese analyses were performed at 15, 30, and 60 days of ripening. Saturated fatty acids were lower in OLI cheese than NOL cheese, while MUFA and PUFA n-3 and n-6 were higher in OLI cheese. Myristic acid (C14:0) and palmitic acid (C16:0) were lower in OLI cheese compared to NOL (8.31% vs. 8.90% and 21.52% vs. 24.95%, respectively), while oleic acid (C18:1 cis-9) was higher in OLI cheese (20.66% vs. 18.78%). Also, CLA cis-9 trans-11 (0.98% vs. 0.84%), and other isomers were higher in OLI cheese. Health indexes, such as the thrombogenic and atherogenic index, were lower in OLI than in NOL cheese (1.96 vs. 2.38 and 1.69 vs. 2.05, respectively) showing the improvement in the health quality of cheese due to olive leaf integration in directly on farm sheep feeding.
Diabetic Ketoacidosis as a Debut and Immune-Mediated Complication Caused by Pembrolizumab: Case Report
Authors: Pacichana Julian Andrés , Osorio Luis Miguel , Restrepo Katherine , García Andres Felipe , Rivas Giovanna , Liscano Yamil
Published: November 2024

Background/Objectives: Diabetic ketoacidosis (DKA) is an acute and potentially life-threatening complication characterized by the accumulation of ketone bodies in the blood, primarily occurring in patients with type 1 diabetes and occasionally in those with type 2 diabetes under certain conditions. DKA presents with symptoms such as polyuria, polydipsia, polyphagia, and, in severe cases, mental status changes. Identifying the triggering factor is crucial to prevent complications and effectively manage this medical emergency. Methods: This report describes the case of a 58-year-old male patient with stage IIIb nodular melanoma, diagnosed in November 2022. Results: After receiving five cycles of pembrolizumab, the patient developed de novo DKA, presenting with blurred vision, asthenia, adynamia, polyuria, and polydipsia. He was admitted to the emergency department with a blood glucose level of 764 mg/dL, confirming hyperglycemia and metabolic acidosis. He was transferred to the intensive care unit for fluid resuscitation and insulin infusion. After adequate clinical evolution and meeting the criteria for DKA resolution, possible autoimmune endocrinopathies secondary to immunotherapy were considered. Due to this complication, the oncological treatment was changed. Finally, the patient was discharged with the need to continue insulin therapy and oral hypoglycemic agents, along with thyroid hormone supplementation. Conclusions: The novelty of this case lies in the presentation of DKA as an immune-mediated complication induced by pembrolizumab, highlighting the importance of closely monitoring patients receiving immune checkpoint inhibitors to detect and manage emerging autoimmune endocrinopathies. It is essential to adjust oncological treatment according to the patient’s response and promptly manage autoimmune endocrinopathies to improve clinical outcomes and the patient’s quality of life.
A Hybrid Quantum-Classical Model for Stock Price Prediction Using Quantum-Enhanced Long Short-Term Memory
Authors: Kea Kimleang , Kim Dongmin , Huot Chansreynich , Kim Tae-Kyung , Han Youngsun
Published: November 2024

The stock markets have become a popular topic within machine learning (ML) communities, with one particular application being stock price prediction. However, accurately predicting the stock market is a challenging task due to the various factors within financial markets. With the introduction of ML, prediction techniques have become more efficient but computationally demanding for classical computers. Given the rise of quantum computing (QC), which holds great promise for being exponentially faster than current classical computers, it is natural to explore ML within the QC domain. In this study, we leverage a hybrid quantum-classical ML approach to predict a company’s stock price. We integrate classical long short-term memory (LSTM) with QC, resulting in a new variant called QLSTM. We initially validate the proposed QLSTM model by leveraging an IBM quantum simulator running on a classical computer, after which we conduct predictions using an IBM real quantum computer. Thereafter, we evaluate the performance of our model using the root mean square error (RMSE) and prediction accuracy. Additionally, we perform a comparative analysis, evaluating the prediction performance of the QLSTM model against several other classical models. Further, we explore the impacts of hyperparameters on the QLSTM model to determine the best configuration. Our experimental results demonstrate that while the classical LSTM model achieved an RMSE of 0.0693 and a prediction accuracy of 0.8815, the QLSTM model exhibited superior performance, achieving values of 0.0602 and 0.9736, respectively. Furthermore, the QLSTM outperformed other classical models in both metrics.
Microchannel Heat Sinks—A Comprehensive Review
Authors: Ghani Usman , Wazir Muhammad Anas , Akhtar Kareem , Wajib Mohsin , Shaukat Shahmir
Published: November 2024

An efficient cooling system is necessary for the reliability and safety of modern microchips for a longer life. As microchips become smaller and more powerful, the heat flux generated by these chips per unit area also rises sharply. Traditional cooling techniques are inadequate to meet the recent cooling requirements of microchips. To meet the current cooling demand of microelectromechanical systems (MEMS) devices and microchips, microchannel heat sink (MCHS) technology is the latest invention, one that can dissipate a significant amount of heat because of its high surface area to volume ratio. This study provides a concise summary of the design, material selection, and performance parameters of the MCHSs that have been developed over the last few decades. The limitations and challenges associated with the different techniques employed by researchers over time to enhance the thermal efficiency of microchannel heat sinks are discussed. The effects on the thermal enhancement factor, Nusselt number, and pressure drop at different Reynold numbers in passive techniques (flow obstruction) i.e., ribs, grooves, dimples, and cavities change in the curvature of MCHSs, are discussed. This study also discusses the increase in heat transfer using nanofluids and how a change in coolant type also significantly affects the thermal performance of MCHSs by obstructing flow. This study provides trends and useful guidelines for researchers to design more effective MCHSs to keep up with the cooling demands of power electronics.
Historical Evolution and Current Developments in Building Thermal Insulation Materials—A Review
Authors: Klemczak Barbara , Kucharczyk-Brus Beata , Sulimowska Anna , Radziewicz-Winnicki Rafał
Published: November 2024

The European Climate Law mandates a 55% reduction in CO2 emissions by 2030, intending to achieve climate neutrality by 2050. To meet these targets, there is a strong focus on reducing energy consumption in buildings, particularly for heating and cooling, which are the primary drivers of energy use and greenhouse gas emissions. As a result, the demand for energy-efficient and sustainable buildings is increasing, and thermal insulation plays a crucial role in minimizing energy consumption for both winter heating and summer cooling. This review explores the historical development of thermal insulation materials, beginning with natural options such as straw, wool, and clay, progressing to materials like cork, asbestos, and mineral wool, and culminating in synthetic insulators such as fiberglass and polystyrene. The review also examines innovative materials like polyurethane foam, vacuum insulation panels, and cement foams enhanced with phase change materials. Additionally, it highlights the renewed interest in environmentally friendly materials like cellulose, hemp, and sheep wool. The current challenges in developing sustainable, high-performance building solutions are discussed, including the implementation of the 6R principles for insulating materials. Finally, the review not only traces the historical evolution of insulation materials but also provides various classifications and summarizes emerging aspects in the field.
Optimizing Energy Renovation in Building Portfolios: Approach and Decision-Making Platform
Authors: Castagna Marco , Somova Olga , Pozza Cristian , De Michele Giuseppe , Garzia Federico , Antonucci Daniele , Pernetti Roberta
Published: November 2024

The building sector contributes significantly to energy consumption and greenhouse gas emissions, with many buildings being energy inefficient. In response, the European Green Deal promotes improving energy efficiency to support decarbonization goals. However, managing energy consumption and integrating data from multiple sources presents challenges, especially for large building portfolios. This study introduces a novel methodology designed to optimize energy renovation strategies, balancing technical, financial, and maintenance considerations. The methodology is implemented in CERPlan 1.0, a web-based decision-support platform that combines data on building energy performance, renovation costs, and maintenance needs. Through simulations, CERPlan 1.0 helps decision-makers prioritize retrofit interventions based on economic criteria while leveraging synergies between energy improvements and regular maintenance. Application of this methodology to real estate portfolios reveals opportunities to enhance cost-effectiveness and energy savings. The results show that integrating maintenance into renovation planning reduces payback times and allows for more comprehensive renovation strategies. The conclusions highlight CERPlan 1.0’s potential to improve decision-making, making building renovations more efficient and sustainable.
Multi-Criteria Optimization of the Paper Production Process Using Numerical Taxonomy Methods: A Necessary Condition for Predicting Heat and Electricity Output in a Combined Heat and Power (CHP) System
Authors: Polek Daria , Niedoba Tomasz , Jamróz Dariusz
Published: November 2024

The subject of this study is the optimization of the paper production process in one of Poland’s leading paper mills. In addition to its primary objective of paper production, the company generates heat and electricity for internal consumption and external clients, including the local municipality. Surplus energy may be sold on the power exchange; however, this requires forecasting the quantity of energy to be sold 24 h in advance, which introduces an element of uncertainty. Production stoppages, often caused by random events such as paper breakage, force a power decrease in the CHP system, further complicating energy forecasting. To minimize the occurrence of such events, numerical taxonomy methods were employed to determine the optimal screen speed (Vs) and winding speed (Vn) for two paper machines, based on the type and weight of the paper produced. This analysis utilized detailed daily data collected by the company over the period 2015–2020. The findings contribute to minimizing the occurrence of paper roll tearing, thereby reducing the risk of inaccurate forecasts of the energy and heat produced by the CHP system. Furthermore, the methodology employed in this study may be effectively applied to other optimization problems in industrial processes.
Efficiency Ranking of Photovoltaic Microinverters and Energy Yield Estimations for Photovoltaic Balcony Power Plants
Authors: Krauter Stefan , Bendfeld Jörg
Published: November 2024

The market for microinverters is growing, especially in Europe. Driven by rising electricity prices and an easing in legislation since 2024, the number of mini-photovoltaic energy systems (mini-PVs) being installed is increasing substantially. Indoor and outdoor studies of microinverters have been carried out at Paderborn University since 2014. In the indoor lab, conversion efficiencies as a function of load have been measured with high accuracy and ranked according to Euro and CEC weightings; the latest rankings from 2024 are included in this paper. In the outdoor lab, energy yields have been measured using identical and calibrated crystalline silicon PV modules; until 2020, measurements were carried out using 215 Wp modules. Because of increasing PV module power ratings, 360 Wp modules were used from 2020 until 2024. In 2024, the test modules were upgraded to 410 Wp modules, taking into account the increase from 600 W to 800 W of inverter power limits, which is suitable for simplified operation permission (“plug-in”) in many European countries within a homogenised legislation area for such mini-photovoltaic energy systems or “balcony power plants”. This legislation for simplified operation also covers overpowered mini-plants, although the maximum AC output remains limited to 800 W. Presently, yield assessments are being carried out in the outdoor lab, which will take at least a year to be valid and comparable. Kits consisting of PV modules, inverters, and mounting systems are also being evaluated. Yield rankings sometimes differ from efficiency rankings due to the use of different MPPT algorithms with different MPP approach speeds and accuracies. To accelerate yield assessment, we developed a novel, simple formula to determine energy yield for any module and inverter configuration, including overpowered systems. This is a linear approach, determined by just two coefficients, a and b, which are given for several inverters. To reduce costs, inverters will be integrated into the module frame or the module terminal box in the future.
Effect of Ultra-High-Pressure Treatment on Gastrodia elata Blume: Drying Characteristics, Components, and Neuroprotective Activity
Authors: Dong Hongjing , Liu Shuang , Wang Xinming , Li Meng , Perumpuli Arachchige Buddhika Niroshie , Wang Xiao
Published: November 2024

Gastrodiae Rhizoma (GE), a popular food in China, is stored and consumed after steaming, which can lead to the degradation of active substances and a decrease in its quality. Therefore, this study explored the potential application of ultra-high-pressure (UHP)-assisted hot air drying in improving the quality of GE. The results indicated that UHP pre-treatment could preserve the original cross-sectional color of GE and increase the degrees of freedom of water in GE samples. Compared with traditional steaming pre-treatment (18 h), UHP pre-treatment at 500 MPa significantly shorted the time (10 h) required for the GE samples to reach drying equilibrium. Meanwhile, the UHP-assisted hot air drying method (60 °C) could reduce the activity of β-D-glucosidase and avoid the degradation of active substances. Finally, UHP pre-treatment improved the neuroprotective activity in vivo. Overall, UHP-assisted hot air drying could improve the quality of GE samples. This study provides a simple method for improving the quality of GE samples and offers a reference for subsequent research on the influence of UHP on GE.
Children’s Diets and Planetary Health: A Study in Wroclaw, Poland, and Sydney, Australia
Authors: Orkusz Agnieszka , Bogueva Diana
Published: November 2024

Meals served to children should not only satisfy hunger and taste preferences but also be nutritionally adequate. Nutrition in early childhood is critical, as children spend a significant portion of their day in kindergarten or preschool, making these settings key contributors to their overall dietary intake. With the rising prevalence of nutrition-related health conditions among children, early interventions are essential for developing and establishing lifelong healthy eating habits. This study assessed the nutritional value and quality of children’s diets in two distinct settings: kindergartens in Wroclaw, Poland, and preschools in Sydney, Australia, evaluating their alignment with the planetary health diet. The research analysed 10-day menu cycles from five kindergartens in Wroclaw and the contents of lunchboxes from five preschools in Sydney’s Upper North Shore area. A total of 100 menus were reviewed in Poland, while 100 children’s lunchboxes were assessed in Australia. Different analytical methods were employed: the Diet 6D software program for the Polish menus and the Food Consumption Score for the Australian lunchboxes. Both methods revealed dietary imbalances, such as excessive intake of protein, vitamin A, salt, and sugar, alongside deficiencies in calcium, vitamin C, and vitamin D. The study concluded that children’s diets should adhere to nutritional guidelines, meeting both Polish and Australian standards, and align with the principles of the planetary health diet. To achieve this, nutritional education is essential for kindergarten staff in Poland, while targeted educational interventions are needed for parents and children in both Poland and Australia, promoting health and environmental sustainability through better nutrition.
Weight Status Change from Birth to Childhood and High Blood Pressure in Childhood
Authors: Liu Ziqi , Yang Lili , Zhao Min , Yu Yongfu , Xi Bo
Published: November 2024

Background: While both high birth weight and childhood overweight/obesity have been associated with a heightened risk of high blood pressure (BP) during childhood, the association between weight status change from birth to childhood and the risk of high BP has not been fully explored. This study aimed to investigate how changes in weight status from birth to childhood influence the development of high BP in childhood. Methods: The data for this study were obtained from the baseline survey of the Huantai Childhood Cardiovascular Health Cohort Study, which included 1237 children aged 6 to 11. Children with a birth weight under 2500 g or a body mass index (BMI) below the fifth percentile for their age and sex during childhood were excluded. Based on birth weight (high birth weight [>4000 g] vs. healthy [≤4000 g]) and childhood weight status (overweight [including obesity] vs. healthy weight), participants were categorized into four groups: consistently healthy weight, weight decrease, weight increase, and consistently excess weight. Results: Compared to children who maintained a healthy weight from birth to childhood, higher odds of childhood high BP was observed among those with consistently excess weight (odds ratio [OR] = 2.73, 95% confidence interval [CI] = 1.46–5.12) and those with a weight increase (OR = 2.77, 95% CI = 1.91–4.02). In contrast, children with a weight decrease did not exhibit significantly higher odds of childhood high BP (OR = 0.94, 95% CI = 0.36–2.45). Conclusion: Children who become overweight in childhood or who consistently had excess weight from birth were at higher risk of childhood high BP. However, the risk of high BP in childhood may be mitigated or eliminated in individuals with high birth weight who achieve a healthy weight by childhood.
Chlorogenic Acid Alleviates Inflammation and Fibrosis in a Murine Model of Bleomycin-Induced Systemic Sclerosis: A Histological Analysis
Authors: Velázquez-Enríquez Juan Manuel , Mendoza-Crisostomo Roxana Clarivel , Reyes-Jiménez Edilburga , Santos-Álvarez Jovito Cesar , Ramírez-Hernández Alma Aurora , González-García Karina , Arellanes-Robledo Jaime , Vásquez-Garzón Verónica Rocío , Baltiérrez-Hoyos Rafael
Published: November 2024

Background/Objectives: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by cutaneous and visceral fibrosis, vascular alterations, and a persistent inflammatory response. Despite advances in understanding the pathogenic mechanisms underlying SSc, current therapeutic options remain limited. Chlorogenic acid (CGA) is a polyphenol widely distributed in plants and has shown antioxidant, anti-inflammatory, and antifibrotic properties. However, its therapeutic potential in SSc has not been investigated yet. Methods: A model of SSc was established by administering bleomycin (BLM) at 100 U/kg to CD1 mice via an osmotic minipump. After fourteen days of BLM administration, CGA (60 mg/kg) was intragastric administered on consecutive days until day 20. On day 21, all mice were sacrificed. The effect of CGA was histologically evaluated by hematoxylin and eosin and Masson’s trichrome staining. Results: CGA treatment significantly attenuated dermal fibrosis in the BLM-induced mice model of SSc by reducing histopathological damage, including increased dermal thickness, inflammation, collagen deposition, and SSc-associated pulmonary fibrosis. Conclusions: The evidence shows that CGA attenuates BLM-induced SSc in a mice model and strongly suggests that CGA may be a promising compound for the treatment of SSc.
Comparison of Multiple Methods for Supraglacial Melt-Lake Volume Estimation in Western Greenland During the 2021 Summer Melt Season
Authors: Rowley Nathan , Rancher Wesley , Karmosky Christopher
Published: November 2024

Supraglacial melt-lakes form and evolve along the western edge of the Greenland Ice Sheet and have proven to play a significant role in ice sheet surface hydrology and mass balance. Prior methods to quantify melt-lake volume have relied upon Landsat-8 optical imagery, available at 30 m spatial resolution but with temporal resolution limited by satellite overpass times and cloud cover. We propose two novel methods to quantify the volume of meltwater stored in these lakes, including a high-resolution surface DEM (ArcticDEM) and an ablation model using daily averaged automated weather station data. We compare our methods to the depth-reflectance method for five supraglacial melt-lakes during the 2021 summer melt season. We find agreement between the depth-reflectance and DEM lake infilling methods, within +/−15% for most cases, but our ablation model underproduces by 0.5–2 orders of magnitude the volumetric melt needed to match our other methods, and with a significant lag in meltwater onset for routing into the lake basin. Further information regarding energy balance parameters, including insolation and liquid precipitation amounts, is needed for adequate ablation modelling. Despite the differences in melt-lake volume estimates, our approach in combining remote sensing and meteorological methods provides a framework for analysis of seasonal melt-lake evolution at significantly higher spatial and temporal scales, to understand the drivers of meltwater production and its influence on the spatial distribution and extent of meltwater volume stored on the ice sheet surface.
Unhealthy Lifestyle Contributes to Negative Mental Health and Poor Quality of Life in Young University Students
Authors: Caamaño-Navarrete Felipe , Saavedra-Vallejos Esteban , Guzmán-Guzmán Iris Paola , Arriagada-Hernández Carlos , Fuentes-Vilugrón Gerardo , Jara-Tomckowiack Lorena , Lagos-Hernández Roberto , Fuentes-Merino Paola , Alvarez Cristian , Delgado-Floody Pedro
Published: November 2024

Background: A negative lifestyle is reported to be related to poor mental health and quality of life (QOL). However, there is little information on this in university students. The objective of the present study was to investigate the association between mental health (i.e., anxiety, depression symptoms and stress), QOL, SWLS and lifestyle parameters (i.e., PA, sleep duration, ST and food habits) among Chilean university students and then to determine the differences in mental health, QOL, SWLS and lifestyle parameters according to gender. Methods: This cross-sectional study included a total of 211 university students (128 females and 83 males) aged 18–28 years. Mental health, QOL and lifestyle were measured through validated questionnaires. Results: Bad food habits (lowest score in the food survey) were linked to anxiety (2.3 [0.22–4.36], p = 0.03), depressive symptoms (3.75 [1.54–5.9], p = 0.001) and stress (2.24 [0.31–4.17], p = 0.023). Furthermore, <6 h of sleep was related to poorer mental health (13.5 [7.6–19.5], p = 0.001), anxiety (4.2 [2.0–6.4], p < 0.001), depressive symptoms (5.5 [3.2–7.9], p < 0.001) and stress (3.8 [1.8–5.9], p < 0.001). In addition, ≥4 h of ST was linked positively to negative mental health (8.3 [2.86–13.7], p = 0.003), depressive symptoms (3.45 [1.47–5.4], p = 0.001) and anxiety (3.2 [1.05–5.4], p = 0.004). Non-physical activity was related to the scores for anxiety (2.6 [0.20–5.0], p = 0.030), depression (2.7 [0.009–5.3], p = 0.049) and stress (2.4 [0.12–4.7], p = 0.039). Conclusions: this study showed that unhealthy lifestyle factors (i.e., insufficient sleep, lack of PA and prolonged ST) were strongly associated with poorer mental health and QOL in university students. These findings highlight the importance of addressing these aspects of lifestyle in intervention and health promotion programs aimed at young university students in order to improve their mental health and overall QOL.
Comfort Care Needs of Allogeneic Stem Cell Transplant Survivors: Lived Experience
Authors: Bacalhau Lúcia , Pontífice-Sousa Patrícia
Published: November 2024

Introduction: Allogeneic Stem Cell Transplantation (ASCT) and, consequently, the chronicity associated with this life event have a growing prevalence and a significant impact on the life and daily life of each person who experiences it. It is necessary to reflect on the care needs of this group of vulnerable people. Comfort is a concern, and its improvement is a desired outcome of healthcare. To achieve this, it is necessary to know the needs of the people who are the focus of care. Aim: This paper aims to understand the needs of comfort care in the lived experience of comfort for survivors of ASCT. Methodology: Qualitative approach using van Manen’s phenomenology of practice. We uncovered the phenomenon through phenomenological interviews, which integrated narratives and illustrative episodes that reflected the lived experience of 20 survivors. Participants in the study were people who had undergone allogeneic hematopoietic progenitor cell transplantation, who were monitored on an outpatient basis and who met the following conditions: (i) were over 18 years old; (ii) had undergone SCT at least 3 months previously; (iii) had no evidence of disease relapse; (iv) were able to express themselves verbally, providing information relevant to the study, as well as expressing emotions and feelings. Descriptions of lived experiences were collected from participants between July 2020 and May 2021. In the phenomenological reflection on the lived descriptions, we followed the “stages” epoché, reduction, and vocative. Results: The following themes emerged from the ASCT survivor’s lived experience of comfort related to comfort care needs: continuous follow-up, reference nurse, information, assistance in adapting to the new self, mental health intervention, spiritual support, adaptation to changes in sexuality, physical rehabilitation, and job reintegration. Conclusion: This study reveals the importance of continuous follow-up for ASCT survivors. Survivors experience major changes in their lives in the long term and require a response from health professionals to find comfort in their daily lives.