bluuebunny/crossref_metadata_2025 huggingface dataset:
Intrinsic and Extrinsic Control of Hepatocellular Carcinoma by TAM Receptors
Authors: Hedrich Viola , Breitenecker Kristina , Djerlek Leila , Ortmayr Gregor , Mikulits Wolfgang
Published: November 2021

Hepatocellular carcinoma (HCC) is the major subtype of liver cancer, showing high mortality of patients due to limited therapeutic options at advanced stages of disease. The receptor tyrosine kinases Tyro3, Axl and MerTK—belonging to the TAM family—exert a large impact on various aspects of cancer biology. Binding of the ligands Gas6 or Protein S activates TAM receptors causing homophilic dimerization and heterophilic interactions with other receptors to modulate effector functions. In this context, TAM receptors are major regulators of anti-inflammatory responses and vessel integrity, including platelet aggregation as well as resistance to chemotherapy. In this review, we discuss the relevance of TAM receptors in the intrinsic control of HCC progression by modulating epithelial cell plasticity and by promoting metastatic traits of neoplastic hepatocytes. Depending on different etiologies of HCC, we further describe the overt role of TAM receptors in the extrinsic control of HCC progression by focusing on immune cell infiltration and fibrogenesis. Additionally, we assess TAM receptor functions in the chemoresistance against clinically used tyrosine kinase inhibitors and immune checkpoint blockade in HCC progression. We finally address the question of whether inhibition of TAM receptors can be envisaged for novel therapeutic strategies in HCC.
Using Electronic Medical Records to Identify Potentially Eligible Study Subjects for Lung Cancer Screening with Biomarkers
Authors: Brown Lamorna , Agrawal Utkarsh , Sullivan Frank
Published: November 2021

Lung cancer screening trials using low-dose computed tomography (LDCT) show reduced late-stage diagnosis and mortality rates. These trials have identified high-risk groups that would benefit from screening. However, these sub-populations can be difficult to access and retain in trials. Implementation of national screening programmes further suggests that there is poor uptake in eligible populations. A new approach to participant selection may be more effective. Electronic medical records (EMRs) are a viable alternative to population-based or health registries, as they contain detailed clinical and demographic information. Trials have identified that e-screening using EMRs has improved trial retention and eligible subject identification. As such, this paper argues for greater use of EMRs in trial recruitment and screening programmes. Moreover, this opinion paper explores the current issues in and approaches to lung cancer screening, whether records can be used to identify eligible subjects for screening and the challenges that researchers face when using EMR data.
Bacterial Extracellular Vesicles in Gastrointestinal Tract Cancer: An Unexplored Territory
Authors: Amatya Sajeen Bahadur , Salmi Sonja , Kainulainen Veera , Karihtala Peeter , Reunanen Justus
Published: November 2021

Bacterial extracellular vesicles are membrane-enclosed, lipid bi-layer nanostructures that carry different classes of biomolecules, such as nucleic acids, lipids, proteins, and diverse types of small molecular metabolites, as their cargo. Almost all of the bacteria in the gut secrete extracellular vesicles to assist them in competition, survival, material exchange, host immune modulation, infection, and invasion. The role of gut microbiota in the development, progression, and pathogenesis of gastrointestinal tract (GIT) cancer has been well documented. However, the possible involvement of bacterial extracellular vesicles (bEVs) in GIT cancer pathophysiology has not been given due attention. Studies have illustrated the ability of bEVs to cross physiological barriers, selectively accumulate near tumor cells, and possibly alter the tumor microenvironment (TME). A systematic search of original published works related to bacterial extracellular vesicles on gastrointestinal cancer was performed for this review. The current systemic review outlines the possible impact of gut microbiota derived bEVs in GIT cancer in light of present-day understanding. The necessity of using advanced sequencing technologies, such as genetic, proteomic, and metabolomic investigation methodologies, to facilitate an understanding of the interrelationship between cancer-associated bacterial vesicles and gastrointestinal cancer is also emphasized. We further discuss the clinical and pharmaceutical potential of bEVs, along with future efforts needed to understand the mechanism of interaction of bEVs in GIT cancer pathogenesis.
Radionuclide-Based Imaging of Breast Cancer: State of the Art
Authors: Li Huiling , Liu Zhen , Yuan Lujie , Fan Kevin , Zhang Yongxue , Cai Weibo , Lan Xiaoli
Published: November 2021

Breast cancer is a malignant tumor that can affect women worldwide and endanger their health and wellbeing. Early detection of breast cancer can significantly improve the prognosis and survival rate of patients, but with traditional anatomical imagine methods, it is difficult to detect lesions before morphological changes occur. Radionuclide-based molecular imaging based on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) displays its advantages for detecting breast cancer from a functional perspective. Radionuclide labeling of small metabolic compounds can be used for imaging biological processes, while radionuclide labeling of ligands/antibodies can be used for imaging receptors. Noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualization of the overexpressed molecular markers in breast cancer, contributing to early diagnosis and better management of cancer patients. The rapid development of radionuclide probes aids the diagnosis of breast cancer in various aspects. These probes target metabolism, amino acid transporters, cell proliferation, hypoxia, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), gastrin-releasing peptide receptor (GRPR) and so on. This article provides an overview of the development of radionuclide molecular imaging techniques present in preclinical or clinical studies, which are used as tools for early breast cancer diagnosis.
Do BARD1 Mutations Confer an Elevated Risk of Prostate Cancer?
Authors: Stempa Klaudia , Wokołorczyk Dominika , Kluźniak Wojciech , Rogoża-Janiszewska Emilia , Malińska Karolina , Rudnicka Helena , Huzarski Tomasz , Gronwald Jacek , Gliniewicz Katarzyna , Dębniak Tadeusz , Jakubowska Anna , Lener Marcin , Tomiczek-Szwiec Joanna , Domagała Paweł , Suszynska Malwina , Kozlowski Piotr , Kluz Tomasz , Naczk Mariusz , Lubiński Jan , Narod Steven A. , Akbari Mohammad R. , Cybulski Cezary ,   on behalf of the Polish Hereditary Prostate Cancer Consortium
Published: November 2021

The current cancer testing gene panels tend to be comprehensive rather than site-specific. BARD1 is one of the genes commonly included in the multi-cancer testing panels. Mutations in BARD1 confer an increase in the risk for breast cancer, but it is not studied whether or not they predispose to prostate cancer. To establish if BARD1 mutations also predispose to prostate cancer, we screened BARD1 in 390 Polish patients with hereditary prostate cancer. No truncating mutations were identified by sequencing. We also genotyped 5715 men with unselected prostate cancer, and 10,252 controls for three recurrent BARD1 variants, including p.Q564X, p.R658C and p.R659=. Neither variant conferred elevated risk of prostate cancer (ORs between 0.84 and 1.15, p-values between 0.57 and 0.93) nor did they influence prostate cancer characteristics or survival. We conclude that men with a BARD1 mutation are not at elevated prostate cancer risk. It is not justified to inform men about increased prostate cancer risk in case of identification of a BARD1 mutation. However, a female relative of a man with a BARD1 mutation may benefit from this information and be tested for the mutation, because BARD1 is a breast cancer susceptibility gene.
Performance of Contrast-Enhanced Ultrasound in Thyroid Nodules: Review of Current State and Future Perspectives
Authors: Radzina Maija , Ratniece Madara , Putrins Davis Simanis , Saule Laura , Cantisani Vito
Published: November 2021

Ultrasound has been established as a baseline imaging technique for thyroid nodules. The main advantage of adding CEUS is the ability to assess the sequence and intensity of vascular perfusion and hemodynamics in the thyroid nodule, thus providing real-time characterization of nodule features, considered a valuable new approach in the determination of benign vs. malignant nodules. Original studies, reviews and six meta-analyses were included in this article. A total of 624 studies were retrieved, and 107 were included in the study. As recognized for thyroid nodule malignancy risk stratification by US, for acceptable accuracy in malignancy a combination of several CEUS parameters should be applied: hypo-enhancement, heterogeneous, peripheral irregular enhancement in combination with internal enhancement patterns, and slow wash-in and wash-out curve lower than in normal thyroid tissue. In contrast, homogeneous, intense enhancement with smooth rim enhancement and “fast-in and slow-out” are indicative of the benignity of the thyroid nodule. Even though overlapping features require standardization, with further research, CEUS may achieve reliable performance in detecting or excluding thyroid cancer. It can also play an operative role in guiding ablation procedures of benign and malignant thyroid nodules and metastatic lymph nodes, and providing accurate follow-up imaging to assess treatment efficacy.
Droplet Digital PCR for BCR–ABL1 Monitoring in Diagnostic Routine: Ready to Start?
Authors: Bochicchio Maria Teresa , Petiti Jessica , Berchialla Paola , Izzo Barbara , Giugliano Emilia , Ottaviani Emanuela , Errichiello Santa , Rege-Cambrin Giovanna , Venturi Claudia , Luciano Luigiana , Daraio Filomena , Calistri Daniele , Rosti Gianantonio , Saglio Giuseppe , Martinelli Giovanni , Pane Fabrizio , Cilloni Daniela , Gottardi Enrico M. , Fava Carmen
Published: November 2021

BCR–ABL1 mRNA levels represent the key molecular marker for the evaluation of minimal residual disease (MRD) in chronic myeloid leukemia (CML) patients and real-time quantitative PCR (RT-qPCR) is currently the standard method to monitor it. In the era of tyrosine kinase inhibitors (TKIs) discontinuation, droplet digital PCR (ddPCR) has emerged to provide a more precise detection of MRD. To hypothesize the use of ddPCR in clinical practice, we designed a multicentric study to evaluate the potential value of ddPCR in the diagnostic routine. Thirty-seven RNA samples from CML patients and five from healthy donors were analyzed using both ddPCR QXDxTMBCR-ABL %IS Kit and LabNet-approved RT-qPCR methodologies in three different Italian laboratories. Our results show that ddPCR has a good agreement with RT-qPCR, but it is more precise to quantify BCR–ABL1 transcript levels. Furthermore, we did not find differences between duplicate or quadruplicate analysis in terms of BCR–ABL1% IS values. Droplet digital PCR could be confidently introduced into the diagnostic routine as a complement to the RT-qPCR.
Phase I Dose-Escalation Trial of an Innovative Chemotherapy Regimen Combining a Fractionated Dose of Irinotecan Plus Bevacizumab, Oxaliplatin, 5-Fluorouracil, and Folinic Acid (bFOLFIRINOX-3) in Chemorefractory Metastatic Colorectal Cancer
Authors: Bellio Hélène , Bertaut Aurélie , Hervieu Alice , Zanetta Sylvie , Hennequin Audrey , Vincent Julie , Palmier Rémi , Bengrine-Lefevre Leila , Ghiringhelli François , Fumet Jean-David
Published: November 2021

The care of metastatic colorectal cancers is based on combination chemotherapies including 5-fluorouracil, oxaliplatin, irinotecan, and monoclonal antibodies targeting the epidermal growth factor receptor or vascular endothelial growth factor. The regimen is determined based on the patient’s molecular biology and general condition. Irinotecan bifractionation showed efficacy in chemorefractory patients in a previous study, FOLFIRI-3, but a desynchronized triplet has never been tested. The aim of bFOLFIRINOX-3 is to determine the safety, tolerance, and efficacy of a new regimen (FOLFIRINOX-3 bevacizumab) in chemorefractory patients. The aim of this study was to evaluate the safety and efficacy of FOLFIRINOX-3 bevacizumab in chemorefractory metastatic colorectal cancer (mCRC). A standard phase I, “3 + 3” design study was performed. The standard protocol comprised simplified FOLFOX 4 (folinic acid 400 mg/m2), 5-fluorouracil (a 400 mg/m2 bolus followed by 2400 mg/m2 for 46 h), oxaliplatin (85 mg/m2) and irinotecan (administered before and after 5-fluorouracil infusion), plus bevacizumab (5 mg/kg). In a “3 + 3” design, three different doses of irinotecan were tested: 60, 70 and 90 mg/m2. The primary endpoint was the maximum tolerable dose (MTD) of irinotecan. The secondary endpoints included the objective response (at 8 and 16 weeks) according to the RECIST 1.1 criteria and progression free survival. Thirteen patients were enrolled, and twelve patients were finally evaluated for dose-limiting toxicity (DLT). The dose level defined was 70 mg/m2 irinotecan. A total of three DLTs were observed (grade 3 diarrhea): two DLTs at the 90 mg/m2 dose level and one at the 70 mg/m2 dose level. The most frequently described adverse events were asthenia (93%), diarrhea (77%), nausea (62%) and peripheral sensory neuropathy (46%). The most frequent biological event was thrombopenia (54%). Regarding efficacy, among the 11 evaluable patients, no progression was observed at 8 weeks, and the partial response rate was 18.2%. At 16 weeks, a partial response rate of 27.3% was observed, and five patients had a stable disease. The new regimen of bFOLFIRINOX-3 with irinotecan at 70 mg/m2 was well tolerated. In chemorefractory patients, this protocol shows a high response rate.
The J2-Immortalized Murine Macrophage Cell Line Displays Phenotypical and Metabolic Features of Primary BMDMs in Their M1 and M2 Polarization State
Authors: Spera Iolanda , Sánchez-Rodríguez Ricardo , Favia Maria , Menga Alessio , Venegas Francisca C. , Angioni Roberta , Munari Fabio , Lanza Martina , Campanella Annalisa , Pierri Ciro L. , Canton Marcella , Castegna Alessandra
Published: November 2021

Macrophages are immune cells that are important for the development of the defensive front line of the innate immune system. Following signal recognition, macrophages undergo activation toward specific functional states, consisting not only in the acquisition of specific features but also of peculiar metabolic programs associated with each function. For these reasons, macrophages are often isolated from mice to perform cellular assays to study the mechanisms mediating immune cell activation. This requires expensive and time-consuming breeding and housing of mice strains. To overcome this issue, we analyzed an in-house J2-generated immortalized macrophage cell line from BMDMs, both from a functional and metabolic point of view. By assaying the intracellular and extracellular metabolism coupled with the phenotypic features of immortalized versus primary BMDMs, we concluded that classically and alternatively immortalized macrophages display similar phenotypical, metabolic and functional features compared to primary cells polarized in the same way. Our study validates the use of this immortalized cell line as a suitable model with which to evaluate in vitro how perturbations can influence the phenotypical and functional features of murine macrophages.
Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers
Authors: McFadden Melayshia , Singh Santosh Kumar , Oprea-Ilies Gabriela , Singh Rajesh
Published: November 2021

Ovarian cancer (OvCa) is a destructive malignancy due to difficulties in early detection and late advanced-stage diagnoses, leading to high morbidity and mortality rates for women. Currently, the quality treatment for OvCa includes tumor debulking surgery and intravenous platinum-based chemotherapy. However, numerous patients either succumb to the disease or undergo relapse due to drug resistance, such as to platinum drugs. There are several mechanisms that cause cancer cells’ resistance to chemotherapy, such as inactivation of the drug, alteration of the drug targets, enhancement of DNA repair of drug-induced damage, and multidrug resistance (MDR). Some targeted therapies, such as nanoparticles, and some non-targeted therapies, such as natural products, reverse MDR. Nanoparticle targeting can lead to the reversal of MDR by allowing direct access for agents to specific tumor sites. Natural products have many anti-cancer properties that adversely regulate the factors contributing to MDR. The present review displays the current problems in OvCa treatments that lead to resistance and proposes using nanotechnology and natural products to overcome drug resistance.
Uygur Destan Dünyasının Kadın Kahramanları
Authors: SOLMAZ Erhan
Published: November 2021

Anlatmaya dayalı edebî eserlerin önemli bir parçası olan kahraman, tahkiyeyi şekillendiren unsurların başında gelir. Kahraman, destanlarda merkezi bir rol oynar. Doğumu, ad alması, silah ve binit sahibi olması, mücadelesi ve nihayetinde de ölümü olağanüstülükler taşır. Kahramanın etrafında şekillenen bu safhalar aynı zamanda yaratıldığı ve mensubu olduğu toplumun insan, dünya, yaşam ve mücadele anlayışını yansıtır. Bir anlamda kahramanı çözümlemek demek, sadece yaratmanın yapısal çözümlemesini yapmak değil; aynı zamanda yaratıldığı toplumun kültürel kodlarını tanımlamak anlamına gelir. Bu bağlamda ele alındığında destanlar ve kahramanları; bu çalışma özelinde de bilhassa kadın kahramanlar, mensubu oldukları toplumun kadın algısını ve kadına karşı bakış açılarına dair de önemli veriler sunar. Bu verilerin değerlendirilmesi toplumların değişim ve dönüşüm süreçlerinin daha yakından tanınmasına olanak sağlar. Bunun yanında da destan gibi kahramanın idealize edildiği metinlerin toplum-insan ölçeğindeki yansımalarını göstermesi bakımından önemlidir.Temel amacımızın Uygur toplumunun ürettiği destanlardaki kadın kahramanların destanlardaki rollerini tespit etmek olduğu çalışmamızda toplumsal cinsiyet çıktısı yapılmamıştır. Bu çalışmada ilk olarak Uygur destan geleneğinden bahsedilecek, ardından da inceleme konusu olarak belirlediğimiz destanlardaki kadın kahramanlar metinlerdeki eylem alanlarına göre tasnif edilmiştir. Bununla birlikte kadın kahramanların destanlar içindeki eylemleri ve ait oldukları toplumdaki konumları çalışmada incelenmiş, sonuç bölümünde de elde edilen veriler ışığında değerlendirmelerde bulunulmuştur.
Presentación
Authors: Baez Mónica
Published: November 2021

A través de este nuevo volumen de la Revista de la Escuela de Ciencias de la Educación de la Facultad de Humanidades y Artes de la Universidad Nacional de Rosario, se renueva el compromiso de esta publicación con la construcción colectiva de saberes acerca de las múltiples dimensiones que constituyen al campo educativo. La transformación de los contextos sociales y educativos a los que ha conducido, entre otros factores, la pandemia- que difícilmente podemos considerar post- obliga a la reflexión conjunta de tópicos preexistentes pero que se han vuelto visibles y fundamentales: la desigualdad de oportunidades para acceder y permanecer en el sistema educativo, las tensiones y disrupciones generadas por políticas recientes que han fragilizado las posibilidades de alcanzar una educación de calidad para todos los sectores sociales, en particular aquellos históricamente excluidos del sistema educativo y con ello con escasas oportunidades de acceso al mundo laboral.
THE EFFECTIVENESS OF DIAZOPHIT APPLICATION IN DIFFERENT FERTILIZATION SYSTEMS AT CULTIVATION OF SPRING WHEAT
Authors: Khomenko G.V. , Berdnikov O.M. , Potapenko L.V. , Gapon O.G. , Lavska V.P.
Published: November 2021

It was established, that the increase of a grain yield of spring wheat at diazophit application makes about 8.6 up to 19,8 % depending on the fertilization system. Yield gain by the use of biopreparation was more cost efficient than from the use of mineral fertilizers. Energy efficiency of diazophit inoculation is the largest in the system with the minimal norm of mineral fertilizers. It had exceeded the control on 19,6 %.
ТHE ELABORATION OF SYSTEM OF COMPLEX USE OF THE MICROBIAL PREPARATIONS IN THE CHICKPEA CULTIVATION AGROTECHNOLOGY
Authors: Lesovoy N.M. , Parkhomenko A.L. , Didovich S.V. , Parkhomenko T.Y. , Chayka V.N.
Published: November 2021

It was established that the presowing seeds bacterization by complexofbiopreparations–Rhizobophyt,Phosphoenterin,Biopolycyde had increased the grain yield of chickpea cultivars Anthey, Budzhak, Pamyat on 1,5-6,0 c/ha (38,0-53,8 %) in comparison to monoinoculation in field experiments on the background of the introduced population of the chickpea rhizobacteria. For the first time was shown the efficiency of biological defense of chickpea from phytophage Liriomyza cicerina Rd. by entomopathogenic strains. Thus, strain В. thuringiensis 0376 had ensured the decrease of plants infection by phytophage Liriomyza cicerina and had increased the chickpea yield in average on 24,5- 98,5 %.
MIKROBIOLOGY IN AGRONOMISTS EDUCATION
Authors: Kanivets V.I. , Chernizki Yu.O.
Published: November 2021

The paper covers the most important issues in microbiology, knowledge of which is necessary for students of agronomics
BIOLOGICAL ACTIVITY OF COMPLEX PREPARATIONS OF MICROBIAL ORIGIN
Authors: Bova T.O. , Reshotko L.M.
Published: November 2021

Article presents the results of biological activity study of complex preparations of microbial origin. It was established that complex preparation created on basis the biocomplex of culture of pseudomonades and yeast manan possess strongly pronounced antiviral activity and stimulatory action on cellular link of animal immunity.
SOIL FUNGI AS BIOTIC FACTOR OF INFLUENCE ON PLANTS
Authors: Kopilov E.P.
Published: November 2021

The article renders the current point of view according to the role of soil molds in plant-microbe interractions. Elucidation of relationship between molds and plants can be scientific basic for elaboration the principles of symbiosis and plant-microbe associations functioning. Thus it opens the way both for creation new environmentally friendly
ORIENTATION OF BIOLOGICAL PROCESSES IN THE ROOT ZONE OF POTATO PLANTS UNDER THE INFLUENCE OF FERTILIZERS AND BIOLOGICAL PREPARATION
Authors: Volkohon V. V. , Zhurba M. A. , Dimova S. B. , Tokmakova L. M. , Volkohon K. I. , Protsenko O. I.
Published: November 2021

The paper covers the results of the orientation of different biological processes (nitrogen fixation, N2O and CO2 emissions) in the root zone of potato plants under the different fertilization systems in a field experiment in stationary experiment on leached black soils. The application of 40 t/ha of cattle manure was shown to be more environmentally beneficial (although with some caution, due to the high level of N2O emissions). The N40P40K40 dose of fertilizers was shown to be optimal, while the balance between environmental requirements and crop productivity shows the practicability of application of N80P80K80. High doses of fertilizers (N120P120K120) and organic mineral fertilization (40 t/ha manure + N80P80K80) had resulted in high levels of N2O and CO2 emissions and reduced nitrogen fixation activity. Application of biological preparation Biogran was shown to be efficient in the potato growing technology due to its proved ability to optimize the ecological condition of soils in agrocoenoses, increase productivity and improve the quality of potatoes.
BIOLOGICAL NITROGEN TRANSFORMATION IN AGROCENOSES OF POTATO AND PRODUCTIVITY OF CULTURE IN ORGANIC AGRICULTURE
Authors: Volkohon V. V. , Dimova S. B. , Volkohon K. I. , Horban V. P. , Zhurba M. A. , Shtanko N. P. , Lutsenko N. V. , Britan T. Yu.
Published: November 2021

The effect of organic fertilizers (cattle manure and lupine green manure), as well asmicrobial preparation Biohran on the dynamics of the activity process of nitrogen fixation andN2O emissions in the rhizosphere soil of potato plants, crop yield, and product quality have beeninvestigated. The use of manures stimulates activity of nitrogen fixation, but at the same time,accompanied by a significant loss of gaseous nitrogen compounds. The efficiency of Biohran bythis agrobackground is largely levelled. Lupine green manure stimulates nitrogenase activity,especially in combination with biopreparation. At the same time, there is a tendency to reducenitrous oxide emission. Organic fertilizers contributed to a reliable raise of potato yield. Biohranprovide productivity gains only on the background of green manure. Microbial preparationcontributed to the improvement of quality of production parameters by all studiedagrobackgrounds.
THE SPATIAL STRUCTURE OF GRAY FOREST SOIL BACTERIAL CENOSIS UNDER DIFFERENT CONDITIONS OF USE
Authors: Malynovska I. M.
Published: November 2021

Under the conditions of the stationary experiment (agrarian soils) and in the 22-year-old deposit areas, the state of microbiocenoses of individual horizons of gray forest soil: humusaccumulative (0–29 cm), illuvial (30–50 cm), transitional from illuvial horizon to solid (92– 110 cm) was studied. It was established that the quantity and physiological and biochemical activity of the microorganisms of the studied ecological-trophic groups, the intensity and direction of the mineralization processes are changing by the soil profile. The nature and extent of such changes significantly depends on the way the soil is used.
DIAZOTROPH ACTIVITY REGULATING STRATEGY UNDER THEIR INTRODUCTION IN AGROCENOSES
Authors: S. F. Kozar
Published: November 2021

Objective. Investigate approaches to managing the activity of soil diazotrophs and propose a strategy for its regulation. Methods. Theoretical, vegetation and field experiments, microbiological, gas chromatographic, mathematical and statistical. Results. The activity of beneficial soil microorganisms can change under the action of temperature, humidity, chemical compounds of various origin, and other microorganisms. It was established that, taking into account a significant variety of factors, it is necessary to develop a set of specific ways to increase the growth and functional activity of nitrogen-fixing bacteria, as well as their viability. It has been proved that the combination of diazotrophs forms an effective symbiotic leguminous-rhizobial system, which provides additional biological nitrogen in agrocenoses. At the same time, there was an increase in plant mass, chlorophyll content in the leaves, protein and oil content in the products. The combined use of diazotrophs increases the yield, in particular, soybeans by 9–16 % compared with inoculation by pure bacterial culture. Conclusion. Based on the analysis and generalization of the obtained research results, a strategy for regulating the activity of diazotrophs for their effective introduction into agrocenoses is proposed, which consists in combining bacteria of different species, selecting conditions for their co-cultivation and application upon stabilisation of the number of viable bacterial cells. The proposed strategy involves solving the problem by obtaining an inoculant, which is characterized by a high titre and a stable number of viable cells, which allows to obtain an effective nitrogen-fixing system. The strategy is tried-and-tested on the example of regulating the growth and functional activity of soybean nodule bacteria by combining diazotrophs of different species, substantiating the conditions of their co-cultivation and application to ensure positive interaction in the form of commensalism, as well as by regulating viability of diazotrophs by adding stabilisers to the medium.
INFLUENCE OF REGIMES OF USE AND FERTILIZATION OF SPONTANEOUSLY RENEWABLE SWARD ON THE COURSE OF SOIL MICROBIOLOGICAL PROCESSES
Authors: І. М. Malynovska , О. P. Soroka , М. М. Ptashnik , V. H. Kurhak
Published: November 2021

Objective. To study the state of the soil microbiocenosis of spontaneously renewable phytocoenosis of the 21st year of self-growth after the application of mineral fertilizers at the dose of N90P40K70 and the two-mow regime. Methods. Experimental-field, laboratory-analytical, microbiological, statistical. Results. Optimization of mineral nutrition of renewable phytocoenosis contributes to an increase in the number of microorganisms: ammonifiers 2.24 times, mineral nitrogen immobilizers — 1.39, denitrifiers — 3.19, nitrifiers — 1.71, cellulose-destructive — 1.64, actinomycetes — 1.17, micromycetes — 1.20, organophosphate mobilizers — 1.33 times. As a result of twomow regime of the use grass cenoses, the number of microorganisms in most of the studied groups does not change, except for denitrifiers, cellulose-destroying bacteria, micromycetes and organophosphate mobilizers. The use of mineral fertilizers leads to a slowdown of mineralization processes in the soil: pedotrophicity index decreases by 2.28 times, the coefficient of mineralization of nitrogen compounds — by 1.60 time, oligotrophicity — by 2.25 times, the activity of humus mineralization — by 1.65 times. Alienation of plant biomass has a negligible effect on the course of microbiological processes in the soil: pedotrophicity index increases by 18.2 %, oligotrophicity coefficient — by 3.63 %, nitrogen mineralization coefficient decreases by 6.6 %, humus mineralization activity — by 6.2 %. Conclusion. Lack of mineral elements in the soil of the fallow provokes the intensification of mineralization processes, and the optimization of mineral nutrition of phytocoenosis plants contributes to their slowing down. The decrease in the total biological activity and the increase in the phytotoxicity of the soil with the two-mow use of sward indicate the beginning of the processes of soil depletion.
THE INFLUENCE OF RHIZOBIUM GALEGAE STRAINS ON THE DEVELOPMENT OF PLANTS OF GALEGA OFFICINALIS AT FIRST AND SECOND YEAR OF CULTIVATION
Authors: Vorobey V.S. , Kovalevska T.M. , Rahmetov D.B.
Published: November 2021

The efficiency of inoculation of Galega officinalis by new strains of rhizobium allocated from nodules of the plant-owner was studied in conditions of field experience. Positive influence of bacterization of the plants by researching strains of nodule bacteria on the basic parameters of legume- rhizobial symbiosis as in the first and second year of vegetation of Galega officinalis is noted. Two strains R. galegae - Л-13 and Л-16 which promote increase in number nodules on roots of plants, activity symbiotic nitrogen fixation, contents of a chlorophyll in leaves of plants and productivity of Galega were selected by results of researches.
BIOINDICATION OF SOIL ECOLOGICAL CONSISTENCE
Authors: Sherstoboeva E. V. , Chabanjuk J.V. , Fedak L.I.
Published: November 2021

Comparative evaluation of virgin and agricultural soil with a minimal system of biological indexes discovered possibility of early diagnostic of soil ecological consistence.
ESTIMATION OF ASSOCIATION LEVEL BETWEEN VIRUSES AT MULTI-HOST INFECTING OF SOUR AND SWEET CHERRY ORCHARDS
Authors: Tryapitcyna N.V.
Published: November 2021

Statistical model for estimation of association level between viruses at multi-host infecting is offered. The association indexes of three pollen-born plant viruses for sweet and sour cherry crops are calculated and analysed.
Indirect NRDF for Partially Observable Gauss-Markov Processes with MSE Distortion: Complete Characterizations and Optimal Solutions
Authors: Stavrou Fotios , Skoglund Mikael
Published: November 2021

In this paper we study the problem of characterizing and computing the nonanticipative rate distortion function (NRDF) for partially observable multivariate Gauss-Markov processes with hard mean squared error (MSE) distortion constraints. For the finite time horizon case, we first derive the complete characterization of this problem and its corresponding optimal realization which is shown to be a linear functional of the current time sufficient statistic of the past and current observations signals. We show that when the problem is strictly feasible, it can be computed via semidefinite programming (SDP) algorithm. For time-varying scalar processes with average total MSE distortion we derive an optimal closed form expression by means of a dynamic reverse-waterfilling solution that we also implement via an iterative scheme that convergences linearly in finite time, and a closed-form solution under pointwise MSE distortion constraint. For the infinite time horizon, we give necessary and sufficient conditions to sure that asymptotically the sufficient statistic process of the observation signals achieves a steady-state solution for the corresponding covariance matrices and impose conditions that allow existence of a time-invariant solution. Then, we show that when a finite solution exists in the asymptotic limit, it can be computed via SDP algorithm. We also give strong structural properties on the characterization of the problem in the asymptotic limit that allow for an optimal solution via a reverse-waterfilling algorithm that we implement via an iterative scheme that converges linearly under a finite number of spatial components. Subsequently, we compare the computational time needed to execute for both SDP and reverse-waterfilling algorithms when these solve the same problem to show that the latter is a scalable optimization technique. Our results are corroborated with various simulation studies and are also compared with existing results in the literature.
Probability-Possibility Transformation under Perspective of Random-fuzzy Dual Interpretation of Unknown Uncertainty
Authors: Mei Wei , Li Gan , Xu Yan , Shi Lin
Published: November 2021

Information-preservation
is recognized as the only principle for probability-possibility transformation in
this work and the normalized transformation is the right method. This is based
on the viewpoint that the reason we can transfer probability and possibility is
that we believe the uncertainty being handled can be information-equivalently
described by both probability and possibility. That viewpoint is endorsed by
the random-fuzzy dual interpretation
of unknown uncertainty, which says that unknown uncertainty being estimated could be
interpreted as either randomness or fuzziness, depending on the available prior
information and the perspective of cognition and modeling. Information of uncertain
variable is defined in this work as its distribution. The suggested
information-preservation principle is different from Klir’s principle, which is
in fact an entropy-preservation principle. Then we investigated the problem of
information preservation and propagation in parallel probability-possibility
systems. By parallel, we mean the two uncertainty systems have the same priori
information. After uncertainty propagation the two parallel systems will
generally bifurcate, which means information preservation only holds locally
between the two parallel systems. This observation accords with our intuition
since probability and possibility use different normalizations as well as different
disjunctive operators, which makes them two different uncertainty systems
appropriate for randomness and fuzziness, respectively.
Integrated Magnetics, Insulation and Cooling Architecture for Slotless Electric Machines
Authors: Lee Dongsu
Published: November 2021

This paper proposes an integrated magnetics, insulation, and cooling architecture to improve the thermal performance of a high
frequency permanent magnet (PM) motor. The proposed architecture can be used for any motor topology to improve its thermal and
insulation performance. The proposed stator yoke design interleaves copper sheets between yoke core lamination to achieve better
thermal conduction from winding to heat sink. A ceramic winding holder is integrated into the armature to introduce a parallel thermal
conduction path from windings to the iron yoke and to provide additional insulation. The architecture is applied to a 300 kW slotless
PM synchronous motor consisting of an outer rotor Halbach PM array, slotless stator, and heatsink. 3D electromagnetic finite element
methods (FEM), 2D heat transfer FEM, and an analytical thermal circuit are used to analyze the architectures impact on torque
production, eddy currents, and thermal performance when compared to the baseline motor. Finally, a pole-pair prototype was built as
a proof-of-concept and to verify the performance benefits of the proposed architecture.
Etika Kenabian dalam Kehidupan Sosial Menurut Muhammad Abdul Aziz Al-Khuly Dalam Kitab Al-Adab Al-Nabawy
Authors: Rasyid Raihan
Published: November 2021

This study aim to explains prophetic ethics as an important issue in social life. For this reason, this study focuses on morality which is one of the main points of study in the book al-Adab an-Nabawy by Muhammad Abdul 'Aziz al-Khūly about prophetic ethics in social life. Through a literature study (Library Research) by exploring the meaning of hadith with techniques of classifying each hadith and focusing on hadith that examines prophetic ethics in the book of al-adab an-Nabawy, this study at least finds that prophetic ethics according to al-Khuly in social life includes good behavior, prohibition of prejudice, prohibition of spying, prohibition of envy, helping, controlling yourself from anger, making things easier and prohibiting making things difficult, prohibition of hurting neighbors and the obligation to respect guests, suggestions for greeting and not asking too many questions.
Evaluation of Milk Production and Milk Composition at Different Stages of Saanen Dairy Goats
Authors: Ibrahim Noor Syaheera , Ahmad Tajuddin Farida Hani
Published: November 2021

Milk is an important elements due to its high nutritious and balanced in human diet. In Asian, goat milk is the most consumed because of the unique taste, more nutritious than cow milk. However, milk production and composition values differ at every stage of lactation in goats. Thus, determining the highest milk production and producing the best quality goat milk is essential to satisfy the local market demands. The objective of the present study is to determine the milk yield and milk composition at different lactation stages and to evaluate the lactation curves in Saanen goats. The lactation stages can be categorized into three, early (less than 80 days), mid (80 – 140 days) and late (over 140 days) days in milk (DIM). In total, 90 milk samples were collected from 15 goats representing early (n=5), mid (n=5), and late (n=5) stages of lactation. The Saanen goats were raised under the same conditions, and milking was done early in the morning (9.00am).The milk yield from Saanen goats were collected and measured weekly at each stage of lactation. Milk samples were analyzed for fat, protein, solid non-fat, and lactose. Current result illustrated, there were significant different (p ˂ 0.05) among three stages of lactation in milk yield, solid non-fat, fat, protein and lactose. In terms of food regulation, the Saanen goats almost fully met the standard requirements for milk production and composition. In addition, this study also observes the lactation curves in Saanen goats and analyse the curve shapes and patterns. The average milk yields from three different stages develops a concave downward curve. The results indicated that mid yield increased from early to mid- lactation and decreased thereafter until the end of lactation.
Indigenous Perspectives on Community Service-Learning in Higher Education: An Examination of the Kenyan Context
Authors: VanLeeuwen Charlene A. , Weeks Lori E. , Guo-Brennan Linyuan
Published: November 2021

To understand community service-learning (CSL) in global contexts, an Indigenous perspective is needed to reflect the range of contextual and historical issues. Theoretical discussions of CSL generally reference theories of experiential and reflective learning; however, work in critical pedagogy and anti-colonial discourse can be utilized to generate a framework that embraces the breadth and depth of CSL in different regions. Extant research on CSL in Africa has found that student learning and development are influenced by pressures faced by the higher education system as well as historical and contextual issues encountered by students while engaged in CSL. As discussed in this article, incorporating an Indigenous perspective within existing theoretical frameworks can enable the development of models, pedagogical approaches, and practices that reflect needs of Kenyan communities. The authors present a rationale for further CSL research in Kenya to ensure culturally sensitive, theoretically sound, and non-exploitive CSL that fosters positive outcomes for students, partner organizations, communities, and higher education institutions.
Rise of Biobanking in the EU: Evidence from the Framework Programmes
Authors: Slušná Ľubica Kotorová , Balog Miroslav , Baláž Vladimír , Nemcová Edita , Filčák Richard , Jeck Tomáš , Antošová Martina
Published: November 2021

he topic of biobanking has been anchoring in the world and Europe as well. The biobanking field today is characterised by heterogeneous entities that could be classified according to many different categories. This article aims to outline the process of the gradual embedding of the field of biobanking in the European Union (EU) from the point of view of the number of high-quality international research projects related to biobanking or biobanks as such. To identify these research projects, data from the European Commission's (EC's) database on research and innovation projects financed from Framework Programmes (FPs) of the European Union and the Horizon programme were used. It was found that the number of research and innovation projects in which biobanks played an important role more than doubled between 1994 and 2021. The highest increase in the number of biobank-related research and innovation projects occurred between 2002 – 2006 and 2007 – 2013. Several leading countries, in terms of the number of biobank related research projects, emerged during the whole period. The main actors were all countries of western Europe, characterised mostly by above-average performance in indicators such as GDP per capita, Human Development Index (HDI) or Euro Health Consumer Index (EHCI).
Increased Employee Productivity with The Application of e-HRM
Authors: Wijayadne Devi Rahnjen
Published: November 2021

This research examines the role of e-HRM (electronic Human Resources Management) in improving employee productivity in higher education. The goal of this empirical study is to confirm and examine this e-HRM usage in higher education. Adaptive structuration theory (AST) is used, to understand the role of e-HRM in improving employee productivity. social factors and technological characteristics interact to affect group outcomes. AST argues that technology usage provides social structures to engage employees in social interaction that both enable and constrain human action within the firm. Research models are analyzed using linear regression and the result is indeed finding a positive effect of e-HRM usage on employee productivity that supports AST. E-HRM can help to streamline operational HRM activities; accelerate HR processes; improve communication between stakeholders include existed employees, potential employees, and management; reduce administrative tasks and HR staff headcount; and capture, create and transfer some HR knowledge more accurately and speedily for employee training and development. These advantages can help to increase employee productivity.
Pengaruh small sided game terhadap keterampilan teknik dasar passing dalam permainan futsal
Authors: Sugandi Gandi , Santosa Agus
Published: November 2021

Tujuan dalam penelitian ini adalah untuk mengetahui latihan small sided game dapat meningkatkan keterampilan teknik dasar passing dalam permainan futsal. Metode dalam penelitian ini adalah metode eksperimen. Desain penelitian ini adalah pre test post test control group design. Populasi dalam penelitian ini adalah seluruh siswa ekstrakulikuler di SMP Taruna Mandiri yang berjumlah 36 siswa. Teknik sampling dalam penelitian ini adalah total sampling. Maka sampel dalam penelitian ini adalah 36 siswa. Instrument penelitian ini menggunakan tes keterampilan teknik dasar passing-stoping. Hasil dari penelitian ini adalah menunjukkan bahwa nilai t hitung lebih besar dari pada t tabel (6.90 > 1.70) yang berarti bahwa small sided game memiliki pengaruh yang signifikan terhadap keterampilan gerak dasar passing dalam permainan futsal di SMP Taruna Mandiri. Kesimpulan penelitian ini yaitu penerapan variasi latihan berbentuk small sided game sangat cocok digunakan dalam olahraga futsal, terutama untuk meningkatkan keterampilan passing.
Otellere İlişkin Yorum Dışı Müşteri Geri Bildirimlerinin Analizi
Authors: TUNA Murat Fatih , AKDOĞAN Şükrü , KAYNAR Oğuz
Published: November 2021

Müşterilerden gelen geri bildirimlerin hızlı ve etkili biçimde değerlendirilmesi, müşterilerle uzun vadeli ilişkilerin kurulabilmesinin gerekliliklerinden biridir. Bu süreçte verimliliğin sağlanması, bilişim teknolojisinin etkin biçimde kullanılmasını zorunlu kılmaktadır. Karmaşık hizmet demetine sahip olan otel işletmeleri gerek konaklama rezervasyonu gerekse hizmet deneyimlerine ilişkin yorum ve değerlendirmeler elde edebilmek amacıyla çevrimiçi rezervasyon sitelerinden faydalanmaktadırlar. Bu çalışmada, yorum dışı müşteri verilerinden hareketle Antalya ilindeki otellere ilişkin hizmet algısının değerlendirilmesi amaçlanmıştır. Burada kullanılan yorum dışı veriler, müşteriler tarafından yorumlara eklenilen otel hizmet kalite kriterlerine yönelik memnuniyet ve tercihlerini belirten derecelendirmelerden ve müşteri bilgilerinden oluşmaktadır. Araştırma kapsamında toplamda 164 otele ait veri analiz edilmiştir. Araştırmadaki tüm hizmet kriterlerinde yurtdışından gelen müşterilerin, yurtiçinden gelen müşterilere göre daha memnun oldukları ortaya konulmuştur. Ayrıca konaklayanların genel memnuniyet ve hizmet memnuniyeti düzeyinin en yüksek ortalamaya sahip olduğu ayın Nisan ayı; uyku kalitesinden duyulan memnuniyetin en yüksek ortalamaya sahip olduğu ayın Aralık ve konum uygunluğundan duyulan memnuniyetin en yüksek ortalamaya sahip olduğu ayın Haziran olduğu saptanmıştır. Çevrimiçi rezervasyon sitelerinden elde edilen otel verilerinin analizi sayesinde, otel işletmelerinin yöneticilerinin hızlı, tutarlı ve maliyet etkin pazarlama kararları almalarının mümkün olabileceği düşünülmektedir.
New species of Labiobaetis Novikova & Kluge from Southeast Asia and New Guinea (Ephemeroptera, Baetidae)
Authors: Kaltenbach Thomas , Gattolliat Jean-Luc
Published: November 2021

Material collected between 2006 and 2016 in Borneo, Sulawesi, and New Guinea further increased our knowledge ofLabiobaetisNovikova & Kluge in these regions. Five species were previously reported from Borneo, two from Sulawesi, and 33 from New Guinea. Six new species have been identified using a combination of morphology and genetic distance (COI, Kimura 2-parameter), one species from Borneo (Brunei), one from Sulawesi, and four from New Guinea. They are described and illustrated based on their larvae and keys to the species of the relevant groups are provided. Additionally, new reports, a complementary description, and the COI sequence forL. dendrisetisKaltenbach & Gattolliat are presented. The distribution ofLabiobaetisin the Wallacea region is discussed based on the new findings. The total number ofLabiobaetisspecies worldwide is augmented to 153.