bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation of Sequential Ligandrol (LGD-4033) Metabolite Levels in Routine Anti-Doping Urine Samples Detected with or without Other Xenobiotics
Authors: Kwiatkowska Dorota , Wicka Mariola , Grucza Krzysztof , Konarski Patryk , Drapała Aleksandra , Kaliszewski Paweł
Published: September 2023

Ligandrol, also known as LGD-4033, belongs to the group of selective androgen receptor modulators (SARMs). Ligandrol was first included in the WADA Prohibited List in 2018. This work presents a method that allows for the detection and identification of ligandrol and its metabolite in athletes’ urine and in dietary supplements by means of ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). Samples were prepared according to an approach involving acid hydrolysis and double liquid–liquid extraction (LLE). Furthermore, due to the lack of reference material for ligandrol metabolites, the urine collected from the control excretion study was analyzed. The presented method is appropriate to monitor ligandrol and its metabolites. The samples collected for doping control purpose contained multiple metabolites, which may potentially rule out the hypothesis of ingesting a single 1 µg or 10 µg dose only. Another aspect to take into account is that ligandrol can be applied together with SARMs, steroids, and GHSs. This will also affect the substances’ metabolism and elimination. It is also worth noting that dietary supplements may contain ligandrol as an official ingredient or as a contaminant. The described method may be usefully applied by other anti-doping or toxicological laboratories.
Nanoscale Ion-Exchange Materials: From Analytical Chemistry to Industrial and Biomedical Applications
Authors: Matczuk Magdalena , Ruzik Lena , Keppler Bernhard K. , Timerbaev Andrei R.
Published: September 2023

Nano-sized ion exchangers (NIEs) combine the properties of common bulk ion-exchange polymers with the unique advantages of downsizing into nanoparticulate matter. In particular, being by nature milti-charged ions exchangers, NIEs possess high reactivity and stability in suspensions. This brief review provides an introduction to the emerging landscape of various NIE materials and summarizes their actual and potential applications. Special attention is paid to the different methods of NIE fabrication and studying their ion-exchange behavior. Critically discussed are different examples of using NIEs in chemical analysis, e.g., as solid-phase extraction materials, ion chromatography separating phases, modifiers for capillary electrophoresis, etc., and in industry (fuel cells, catalysis, water softening). Also brought into focus is the potential of NIEs for controlled drug and contrast agent delivery.
Investigation of 29 Antimicrobial Compounds in Soil Using Newly Developed UHPLC-MS/MS Method
Authors: Gbylik-Sikorska Małgorzata , Gajda Anna , Felipe-Sotelo Monica , Caniça Manuela , Cabal-Rosel Adriana , Tenson Tanel , Kořínková Marta , Arbo Krõõt , Kisand Veljo , Rab Gerhard , Brandtner Martin
Published: September 2023

While the prudent and reasonable use of veterinary antimicrobial agents in food-producing animals is necessary, researchers over the decades have shown that these antimicrobial agents can spread into the environment through livestock manure and wastewater. The analysis of the occurrence of antimicrobial compounds in soil samples is of a great importance to determine potential impacts on human and animal health and the environment. In this study, an affordable, rugged and simple analytical method has been developed for the determination of twenty-nine antimicrobial compounds from five different classes (tetracyclines, fluoro(quinolones), macrolides, sulfonamides and diaminopirimidines). Liquid–liquid extraction (LLE) with extract filtration combined with ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) was the best strategy for the simultaneous determination of all analytes. The developed method was validated according to the Commission Implementing Regulation (EU) 2021/808. The limit of detections (LODs) ranged from 0.5 to 2.0 µg/kg, while the limit of quantitation (LOQ) was established at 1.0 to 20.0 µg/kg. The developed method was successfully applied for the determination of antimicrobial residues in one hundred and eighteen soil samples obtained from four European countries (Austria, Czech Republic, Estonia and Portugal). Doxycycline in the concentration levels of 9.07 µg/kg–20.6 µg/kg was detected in eight of the analysed samples. Samples were collected from areas where natural fertilizers (swine or cow manure) were applied. Our method can be efficiently used to monitor anti-microbial compounds in soil samples.
Synthesis, Antifungal, and Antibacterial Activities of Novel Benzoylurea Derivatives Containing a Pyrimidine Moiety
Authors: An Jiansong , Lan Wenjun , Fei Qiang , Li Pei , Wu Wenneng
Published: September 2023

To explore more efficient and less toxic antibacterial and antifungal pesticides, we utilized 2,6-difluorobenzamide as a starting material and ultimately synthesized 23 novel benzoylurea derivatives containing a pyrimidine moiety. Their structures were characterized and confirmed by 1H NMR, 13C NMR, 19F NMR, and HRMS. The bioassay results demonstrated that some of the title compounds exhibited moderate to good in vitro antifungal activities against Botrytis cinerea in cucumber, Botrytis cinerea in tobacco, Botrytis cinerea in blueberry, Phomopsis sp., and Rhizoctonia solani. Notably, compounds 4j and 4l displayed EC50 values of 6.72 and 5.21 μg/mL against Rhizoctonia solani, respectively, which were comparable to that of hymexazol (6.11 μg/mL). Meanwhile, at 200 and 100 concentrations, the target compounds 4a–4w exhibited lower in vitro antibacterial activities against Xanthomonas oryzae pv. oryzicola and Xanthomonas citri subsp. citri, respectively, compared to those of thiodiazole copper. Furthermore, the molecular docking simulation demonstrated that compound 4l formed hydrogen bonds with SER-17 and SER-39 of succinate dehydrogenase (SDH), providing a possible explanation for the mechanism of action between the target compounds and SDH. This study represents the first report on the antifungal and antibacterial activities of novel benzoylurea derivatives containing a pyrimidine moiety.
Therapeutic Effects of Baicalin on Diseases Related to Gut–Brain Axis Dysfunctions
Authors: Hu Qichao , Hou Shuyu , Xiong Baoyi , Wen Yueqiang , Wang Jundong , Zeng Jinhao , Ma Xiao , Wang Fang
Published: September 2023

The gut–brain axis is an active area of research. Several representative diseases, including central nervous system disorders (Alzheimer’s disease, Parkinson’s disease, and depression), metabolic disorders (obesity-related diseases), and intestinal disorders (inflammatory bowel disease and dysbiosis), are associated with the dysfunctional gut–brain axis. Baicalin, a bioactive flavonoid extracted from Scutellaria baicalensis, is reported to exert various pharmacological effects. This narrative review summarizes the molecular mechanisms and potential targets of baicalin in disorders of the gut–brain axis. Baicalin protects the central nervous system through anti-neuroinflammatory and anti-neuronal apoptotic effects, suppresses obesity through anti-inflammatory and antioxidant effects, and alleviates intestinal disorders through regulatory effects on intestinal microorganisms and short-chain fatty acid production. The bioactivities of baicalin are mediated through the gut–brain axis. This review comprehensively summarizes the regulatory role of baicalin in gut–brain axis disorders, laying a foundation for future research, although further confirmatory basic research is required.
Optical Lines in Europium and Terbium-Activated Yttrium Tantalate Phosphor: Combined Experimental and Group-Theoretical Analysis
Authors: Nazarov Michael , Tsukerblat Boris
Published: September 2023

The rare-earth ions in crystals such as terbium (YTaO4:Tb3+) and europium (YTaO4:Eu3+)-activated yttrium tantalate phosphors have a number of attractive features that predetermine their crucial role in practical application in contemporary optoelectronic devices. In this article, we employ the group-theoretical arguments aimed to reveal the group-theoretical classification of the crystal field levels and selection rules for the allowed optical transition between the crystal field components of Tb3+ and Eu3+ of the low symmetry crystal field in the activated yttrium tantalate phosphors. We also establish possible polarization rules for the lines corresponding to the allowed transitions. We deduce the symmetry-assisted results for the selection rules in the optical transitions accompanied by the absorption/emission of the vibrational quanta. The selection rules for the vibronic satellites of the zero-phonon lines are expected to be useful for the identification of the lines in the spectra of rare-earth ions with a weak vibronic coupling. The results of the low-temperature measurements of photoluminescence under the 325 nm excitation are in compliance with the group-theoretical analysis. The aim of the paper is to establish symmetry-assisted results that are the background of the quantitative crystal field theory based on the quantum-mechanical consideration.
Why Realisms about Fiction Must (and Can) Accommodate Fictional Properties
Authors: Kroon Frederick , Oppenheimer Paul
Published: September 2023

The topic of fictional objects is a familiar one, the topic of fictional properties less so. But it deserves its own place in the philosophy of fiction, if only because fictional properties have such a prominent role to play in science fiction and fantasy. What, then, are fictional properties and how does their apparent unreality relate to the unreality of fictional objects? The present paper explores these questions in the light of familiar debates about the nature of fictional objects.
Nonlocal Soft Plasmonics in Planar Homogeneous Multilayers
Authors: Ramesh Narayan Preethi , David Christin
Published: September 2023

Plasmonics is the study of resonant oscillations of free electrons in metals caused by incident electromagnetic radiation. Surface plasmons can focus and steer light on the subwavelength scale. Apart from metals, plasmonic phenomena can be observed in soft matter systems such as electrolytes which we study here. Resonant charge oscillations can be induced for ions in solution, however, due to their larger mass, they are plasmon-active in a lower frequency regime and on a larger wavelength scale. Our investigation focuses on spatial confinement which allows increasingly strong charge interactions and gives rise to nonlocality or spatial dispersion effects. We derive and discuss the nonlocal optical response of ionic plasmons using a hydrodynamic two-fluid model in a planar homogeneous three-layer system with electrolyte-dielectric interfaces. As in metals, we observe the emergence of additional longitudinal propagation modes in electrolytes which causes plasmonic broadening. Studying such systems enables us to identify and understand plasmonic phenomena in biological and chemical systems.
Functionalized Chiral Twisted Optical Fibers: A Review
Authors: Zhang Yifan , Li Boyao , Huang Tianrong , Zhou Guiyao , Liang Yaoyao
Published: September 2023

With an increase in the volume of information exchange and perception, the demands for intelligent, miniaturized, and integrated optical devices for information acquisition are also increasing. As the core component of optical networks for transmitting information, further optimization of their structural characteristics to generate richer optical characteristics and apply them to information exchange and optical field control has become a key research hotspot. The introduction of chiral twist characteristics has led to new phenomena and applications in optical field transmission and the transformation of traditional optical fibers or microstructured optical fibers (MOF). Therefore, this review mainly begins with the principle of chiral optical fibers, introduces their preparation and latest application scenarios, and finally discusses their potential future development prospects.
Using Plant Functional Traits to Define the Biomass Energy Potential of Invasive Alien Plant Species
Authors: Ceriani Alex , Dalle Fratte Michele , Agosto Gustavo , Montagnoli Antonio , Cerabolini Bruno Enrico Leone
Published: September 2023

The eradication of invasive alien plant species (IAPS) is mandatory worldwide, but the resulting biomass is still considered waste. The energy use of biomasses obtained from IAPS eradication may represent ecological and economic benefits, creating synergies with restoration projects. We evaluated whether the growth forms and functional types identified using the functional space of 63 IAPS corresponded to a possible bioenergy use through multivariate analysis techniques. We extracted leaf and nutrient traits and Grime’s CSR plant strategies from an existing database. We calculated the carbon-to-nitrogen ratio (C:N) and gross heating value (GHV) as indicators of biochemical or thermal processes, respectively. For 10 species, we measured the above-ground biomass C:N and GHV (including leaves, stems and branches) and correlated them with those of leaves and with plant adaptive strategies. We identified four groups of IAPS indicative of the main trade-offs between plant economics and size variation, which respectively correlated with C:N and GHV. Herbaceous IAPS were better suited to biochemical processes, and woody IAPS to thermal ones. Overall, Grime’s CSR strategies were the best tool to define the IAPS bioenergy potential. In the long term, competitive and ruderal IAPSs can represent a reusable feedstock until their complete eradication.
Combined Remediation towards Cadmium–Arsenic-Contaminated Soil via Phytoremediation and Stabilization
Authors: Zhang Chenxu , Wu Jiamei , Cao Jian
Published: September 2023

Using a phytoremediation technique for soil remediation usually takes many years, which increases the risk that heavy metals spread into the environment during the project period. Currently, the combined remediation technique (phytoremediation and stabilization) is known as the solution to reduce this risk. In this study, the combined remediation of cadmium–arsenic-contaminated soil via phytoremediation and stabilization was studied. The pot experiment was carried out using modified fly ash (MFA) and solid waste material (steel slag (SS): pyrolusite (PY): ferrous sulfide (FS) = 1:2:8) as stabilization materials and Bidens pilosa as the accumulative plant. The characteristics of B. pilosa, including its water content, biomass, root length, plant height, and heavy metal content, were obtained after harvesting, and the reduction rate of the bioavailability of Cd and As and their physico-chemical properties, including the pH, Eh, and Ec values of the soil, were also measured. The remediation effect was evaluated according to the above indexes, and the mechanism of combined remediation was studied through the FTIR, XRD, and XPS analyses. These experiments have shown that adding an appropriate amount of MFA can enhance the absorption of heavy metals by plants in the soil and reduce the bioavailability of heavy metals in contaminated soil. In addition, the mechanism study revealed that Cd2+/Cd(OH)+ was easily adsorbed on Si-OH and MnOOH, while AsO43− was more easily adsorbed on Fe-OH and Al-OH.
Analysis of Status Quo of Research on Heavy Metals in Rivers and Lakes Based on Bibliometrics
Authors: Wang Shuhang , Zhang Yaran , Fu Zhenghui , Shi Dong , Wang Yuanyi , Yang Dianhai , Che Feifei
Published: September 2023

Heavy metal pollution in rivers and lakes arising due to rapid economic development has been extensively studied by various countries due to its direct impact on ecological health and human well-being. However, there is a lack of comprehensive and systematic reviews addressing the current research status of this subject. In this study, we conducted a visual metrological analysis of the literature from 2001 to 2021 using the Web of Science (WoS) and China National Knowledge Infrastructure (CNKI) citation databases. The results show that studies conducted in other countries initially outnumbered those in China; after 2010, China emerged as the foremost contributor. Furthermore, both the WoS and CNKI databases indicate active engagement of Chinese researchers through a significant proportion of published papers on metal research, with prominent contributions coming from institutions such as the Chinese Academy of Sciences (CAS) and University CAS. Nevertheless, Chinese research institutions still have relatively low total paper citation numbers and have yet to establish themselves as key players in international scientific research efforts. Additionally, core authors from different countries share substantial similarities in their research directions and focuses. Consistent research hotspots regarding heavy metals in rivers and lakes were identified across both databases, including heavy metal pollution, adsorption, human activities, water quality, and sediment.
Teacher Resilience and Coping with Teacher Stress in Vocational Schools
Authors: Barnová Silvia , Gabrhelová Gabriela , Krásna Slávka , Hasajová Lívia , Barna Denis
Published: September 2023

The aim of the proposed study is to present the partial results of research activities focused on vocational school teachers’ resilience realized within the grant project IGA003DTI/2022. The present study aims to examine the existence of associations between teacher resilience and years of teaching experience. The research sample consisted of 474 vocational school teachers in Slovakia. The level of their teacher resilience was measured by The Connor–Davidson Resilience Scale CD-RISC-25SLOVAK. The scale measures seven dimensions—Hardiness, Coping, Adaptability/Flexibility, Meaningfulness/Purpose, Optimism, Regulation of emotion and cognition, and Self-Efficacy. The findings confirmed the existence of associations between teacher resilience and years of teaching experience as novice teachers and teachers with ten or fewer years of teaching experience achieved lower scores in the scale than their more experienced colleagues. Although we are aware of the limits of the research study given the size and composition of the sample, the findings suggest that years of teaching experience can be considered an important variable from the aspect of teacher resilience and it is important to pay increased attention especially to novice teachers’ well-being and building their resilience, e.g., by providing guidance through developing effective coping strategies. As there are a lack of available data on vocational school teachers’ resilience, the present findings have the potential to broaden the existing knowledge and have implications for further research.
Beyond Disciplinary Constraints: Designing Transdisciplinary Research and Collaboration in Real-World Laboratories
Authors: Kofler Ingrid
Published: September 2023

Topics related to sustainable development are at the forefront of current local and global debates, involving social, economic, and political perspectives. To address these complex and interconnected challenges, it is necessary to think and act beyond disciplinary and field-specific boundaries. Participating in project work, research, experiments, and designing social transformation processes are at the core of transdisciplinary research and methods, such as Real-World Laboratories. This means that all participants are involved in co-designing, co-producing, and co-disseminating the project from the beginning. In these participatory processes, a systematic evaluation and evidence of the transdisciplinary process is often difficult to show even though it would be important to improve scalability and the transferability of the process. Using the example of the Tiny Fop Mob, a Real-World Laboratory on wheels, we wanted to understand how to evaluate transdisciplinary research thinking within the project team and demonstrate how systematic evaluation is crucial in participatory research. Findings show that there is a need to reflect on context-specific and team-oriented strategies during the planning and the beginning of the project.
Perceptions and Acceptance of Artificial Intelligence: A Multi-Dimensional Study
Authors: Gerlich Michael
Published: September 2023

In this comprehensive study, insights from 1389 scholars across the US, UK, Germany, and Switzerland shed light on the multifaceted perceptions of artificial intelligence (AI). AI’s burgeoning integration into everyday life promises enhanced efficiency and innovation. The Trustworthy AI principles by the European Commission, emphasising data safeguarding, security, and judicious governance, serve as the linchpin for AI’s widespread acceptance. A correlation emerged between societal interpretations of AI’s impact and elements like trustworthiness, associated risks, and usage/acceptance. Those discerning AI’s threats often view its prospective outcomes pessimistically, while proponents recognise its transformative potential. These inclinations resonate with trust and AI’s perceived singularity. Consequently, factors such as trust, application breadth, and perceived vulnerabilities shape public consensus, depicting AI as humanity’s boon or bane. The study also accentuates the public’s divergent views on AI’s evolution, underlining the malleability of opinions amidst polarising narratives.
Universality in the Exact Renormalization Group: Comparison to Perturbation Theory
Authors: Gaite José
Published: September 2023

Various formulations of the exact renormalization group can be compared in the perturbative domain, in which we have reliable expressions for regularization-independent (universal) quantities. We consider the renormalization of the λϕ4 theory in three dimensions and make a comparison between the sharp-cutoff regularization method and other more recent methods. They all give good results, which only differ by small non-universal terms.
Factors Affecting COVID-19 Vaccine Acceptance among Pregnant Women: A Cross Sectional Study from Abha City, Saudi Arabia
Authors: Habbash Asma Saad , Siddiqui Aesha Farheen
Published: September 2023

Background: Pregnant women can get infected with COVID-19 with serious sequelae to them and their fetus. Concerns about COVID-19 vaccination safety to mothers and babies, and doubts about its effectiveness, have hindered vaccine acceptance throughout the COVID-19 crisis. The objective of the current investigation was to estimate COVID-19 acceptance rates among pregnant women in Abha city, Aseer region, Saudi Arabia, and determine its clinical and demographic correlates. Method: Descriptive questionnaire-based cross-sectional survey of a sample of pregnant women attending regular antenatal care services in Abha. We used backward stepwise multiple logistic regression analysis to evaluate the predictability of vaccine acceptance in terms of baseline clinical and demographic factors. Results: The survey included 572 pregnant women. The prevalence of acceptance of COVID-19 vaccine was high (93.7%; 95%CI: 91.7–95.7%). University graduates and women with a later gestational age were more likely to accept vaccination (OR = 6.120, p = 0.009), (t = 2.163, p = 0.036), respectively. Confidence in vaccine safety was associated with better acceptance (OR = 3.431, p = 0.001). Conclusions: The acceptance rate for vaccination among pregnant women in Abha, Saudi Arabia, is higher compared to international rate. However, our results indicate that confidence in vaccine safety was associated with better acceptance. Hence, vaccine safety was the overarching predictor for harboring positive attitudes towards it. Public health policies should capitalize on such positive attitudes and aim for total coverage of pregnant women with COVID-19 vaccination including booster dosages.
Sending a Message: Use of mRNA Vaccines to Target the Tumor Immune Microenvironment
Authors: Ramirez Fabiola , Zambrano Angelica , Hennis Robert , Holland Nathan , Lakshmanaswamy Rajkumar , Chacon Jessica
Published: September 2023

While cancer immunotherapies have become central to treatment, challenges associated with the ability of tumors to evade the immune system remain significant obstacles. At the heart of this issue is the tumor immune microenvironment, the complex interplay of the tumor microenvironment and the immune response. Recent advances in mRNA cancer vaccines represent major progress towards overcoming some of the challenges posed by deleterious components of the tumor immune microenvironment. Indeed, major breakthroughs in mRNA vaccine technology, such as the use of replacement nucleotides and lipid nanoparticle delivery, led to the vital success of mRNA vaccine technology in fighting COVID-19. This has in turn generated massive additional interest and investment in the platform. In this review, we detail recent research in the nature of the tumor immune microenvironment and in mRNA cancer vaccines and discuss applications by which mRNA cancer vaccines, often in combination with various adjuvants, represent major areas of potential in overcoming tumor immune microenvironment-imposed obstacles. To this end, we also review current mRNA cancer vaccine clinical trials.
Water Masses of the Mediterranean Sea and Black Sea: An Overview
Authors: Poulos Serafeim E.
Published: September 2023

This overview presents the different water masses present in the various primary and secondary marine regions of the Mediterranean Sea and Black Sea, providing information on their main physical characteristics (i.e., temperature, salinity, density), the water depths at which they have been observed and the processes involved in their formation. There is a characteristic difference in the overall hydrology of the Mediterranean Sea compared to the Black Sea, in terms of the number and characteristics of water masses and their formation processes, although they form a single (integrated) marine system. This difference is explained by the limited communication between the two seas through the Sea of Marmara and its straits (the Dardanelles and Bosporus) and by the fact that the Mediterranean Sea is a condensation basin while the Black Sea is a dilution basin; therefore, the deficit of water in the former is compensated by the inflow of Atlantic waters, while the surplus in the latter outflows to the Aegean Sea. In total, 21 different water masses have been identified in the Mediterranean Sea (excluding the Straits of Gibraltar and the Sea of Marmara) compared to the 5 water masses identified in the Black Sea (excluding the Sea of Azov). This large number of water masses is attributed to coastal morphology (i.e., presence of straits) and submarine relief (i.e., deep basin separated by shallow sills) and different formation processes.
Optimization of energy saving of an industrial and warehouse real estate enterprise
Authors:   Production and warehouse complex Baza Big, Russia, Republic of Tatarstan, Bondareva I.G.
Published: September 2023

The material is devoted to the application of methods and tools of lean production at industrial and warehouse facilities and, in particular, the issue of using modern technologies in warehouses to reduce energy consumption costs and minimize the harmful contribution to the environment is considered.
Relationship between mothers' and children's attitudes with and without ADHD toward elementary school and homework
Authors: Cavenaghi Anna , Hébert Élizabeth , Monnier Juliette , Roy-Côté Frédérique , Ross Gabrielle , Baril André-Ann , Scavone Geneviève
Published: September 2023

Attitude toward school predicts performance in school. Understanding the factors influencing a child’s attitude towards school is important, especially in children with an Attention Deficit Hyperactivity Disorder (ADHD) who face difficulties at school. The relationship between children’s attitude, perceived by their mother, and their mother’s attitude toward school and homework will be examined. This study includes a group of 45 children with a diagnosis of ADHD (M = 9.42 year; 12 girls) and a group of 45 children without diagnoses (M = 9.42 year; 15 girls). The child’s perceived attitude toward school and homework was significantly associated with the mother’s attitude toward homework in both groups without (r = .46 and .78) and with ADHD (r = .43 and .58). A lower frequency of ADHD and a mother of older age distinguished children with a positive attitude toward school. The practical benefits are then discussed.
DEVELOPMENT OF SCIENTIFIC AND METHODOLOGICAL PRINCIPLES FOR MEASURING THE ECONOMIC SECURITY
Authors:   Mariupol State University, Karpenko О.
Published: September 2023

The article is devoted to the research of the scientific and methodological principles for measuring the economic security level. The author focuses attention on the features and elements of the estimation process, and the relationships between different elements. The article forms a system of interrelationships between estimation elements: estimation direction – nature (type) of estimation – estimation tools – security assessment results. The article contains a comprehensive approach to the assessment of economic security developed by the author, which includes a combination of different focuses of assessing the elements of the economic security system at different hierarchical levels (global, regional and national), namely the assessment of the global security environment through the analysis of threats and risks; multi-criteria assessment of countries' positions in the global economic environment; comparative analysis of regional security complexes; assessment of the foreign trade component in the system of economic security, analysis of national features of the countries’ economic security system. The developed approach allows to obtain a comprehensive vision of the features economic security system of the national economies operating in conditions of rapid transformations of the global environment. To assess threats and risks, it is proposed to use a survey procedure using the questionnaire method, which will allow to obtain an expert assessment of the factors of the security environment. Such a questionnaire may include a previously formed list of risks and threats of various nature and contain open questions, which allowed the involved experts to add other factors not taken into account or omitted in the given list. The peculiarity is that experts need to evaluate each risk or threat according to such evaluation criteria as the probability of occurrence, the strength of the influence on the socio-economic development security, the period of potential impact on the security level, which will allow to provide a quantitative dimension to the threats and risks and rank them by value. Key words: security, economic security, estimation process, security environment, threat, risk.
TYPES AND MECHANISM OF DEVELOPMENT AND IMPLEMENTATION OF ORGANIZATIONAL CULTURES: THE EXPERIENCE OF MULTINATIONAL AND UKRAINIAN COMPANIES AND CURRENT TRENDS OF HR MANAGEMENT IN THE CONDITIONS OF WAR
Authors: Shymanovska-Dianych L. M. , Lozova O. V. , Barybina Ya. O. , Shymanovska V.L. ,   Poltava University of Economics and Trade,   Poltava University of Economics and Trade,   Poltava University of Economics and Trade,   Educational and Scientific Institute of Correspondence and Distance Learning
Published: September 2023

The purpose of this article is the development of theoretical and methodological provisions regarding the typology and formation of the organizational culture of enterprises and organizations and the development of proposals for its implementation in the activities of Ukrainian enterprises in modern conditions. Research methodology. The goal set in the article was achieved using the following research methods: logical generalization and scientific abstraction, structural analysis, analytical method. The results. The process of developing and improving organizational culture does not stop at domestic enterprises even during the war. On the contrary, the war significantly changed the values of companies, strengthened corporate social responsibility, not only wages became important for employees, but also a sense of belonging to the company, unity of the team and understanding that everyone in the company works for a common goal. The types and mechanism of development and implementation of organizational cultures are outlined. The experience of multinational and Ukrainian companies is summarized. Modern trends in HR management in wartime conditions at domestic enterprises have been determined. Practical significance of research results. Increasing the efficiency of Ukrainian enterprises, especially in wartime, requires a serious attitude to such a management element as organizational culture, taking into account the latest trends in personnel management. The practical use of the proposed theoretical and applied approaches will allow to raise the level of organizational culture in multinational and Ukrainian companies, to improve its development process and the mechanism of implementation at the enterprise. Key words: organizational culture, multinational company, types of organizational culture, mechanism of implementation of organizational culture, war, challenges, crisis, values.
Data Framework for Retrieving Failure Information from Earlier Plant Engineering Projects
Authors: Egel Robert , Karch Sabrina , Kuhlenkötter Bernd , Lüder Arndt
Published: September 2023

Failures in context of industrial production are not only a burden and a main reason for committee and rework but can also be a chance. When failures occur within organizations, several authors and publications have pointed out the opportunities that come with them. Through failures, an organization gets the possibility to improve corresponding processes and avoid future mistakes preventively. This is especially true for manufacturing companies. Their customers trust that products are of a continuously high quality. In addition, these companies are facing enormous challenges, for example a higher product variety or an increasing product and production plant complexity. In times of limited human and financial resources, these challenges have a huge influence on the transfer of failure information. Often, companies (are forced to) have a structured process for how to handle failures within the organization, but fail to transfer the important information gained from them to a parallel plant or to a future project. Therefore, the aim of this paper is to present a framework, which allows retrieving earlier failures at the early stage of the plant engineering phase. This serves as a basis for the further development of a supporting system in the FertiRob project. To ensure transferability in industrial practice, the framework is explained using a real-life application demonstrator. In addition, an adjusted Why-Not-Analysis with (industry) project partners is conducted. This analysis shows that there are points that need to be considered in further development while the basic implementation is possible.
Great Resignation and Quiet Quitting as Post-pandemic Dangers to Knowledge Management
Authors: Zieba Krzysztof
Published: September 2023

COVID-19 pandemic aftermaths include the emergence of new tendencies, such as the Quiet Quitting, and continuation of trends such as the Great Resignation, both of which have multiple knowledge-related impacts on individual, organizational and even national level. The aim of this paper is to show the mechanisms behind the Quiet Quitting and the Great Resignation from individual and organizational perspectives. Understanding them is the first step to developing remedies and building business resilience. The paper uses systems thinking approach to analyse the phenomena of the Quiet Quitting. Causal loop diagrams are used to show the mechanisms behind those tendencies, their antecedents and the impact they have on several aspects of business operation and management. The Quiet Quitting and the Great Resignation are multifaceted phenomena and pose several knowledge-related dangers to organizations, including disturbed knowledge flows, knowledge loss, diminished efficiency, lost informal friendship networks, and knowledge leakage to competition. Causal loop diagram indicates that complicated relations between various elements may produce surprising and unexpected outcomes. It presents also opportunities to use leverage points in order to substantially reduce negative outcomes. The paper is of a conceptual nature. In order to transform causal loop diagrams into full systems thinking models extensive data is required. Hence this paper is intended as a basis for further research. The understanding of mechanisms behind the Great Resignation and the Quiet Quitting is crucial for managers trying to develop strategies that would tackle those problems. The papers shows what leverage points can be used to mitigate risks of their adverse impact on business organizations. The Great Resignation and the Quiet Quitting are often perceived as results of the COVID-19 pandemic, yet data suggest they remain strong also in the post-pandemic business reality. The paper offers a holistic approach to those phenomena using individual and organisational perspectives. It provides important insights into their nature, which can be useful to numerous stakeholders, including knowledge workers, managers and business owners.
THE EFFECT OF INTELLECTUAL CAPITAL ON SUSTAINABLE GROWTH MODERATED BY THE GREEN INNOVATION STRATEGY
Authors: Kawilarang Medeleen Florencia , Daromes Fransiskus E. , Tangke Paulus
Published: September 2023

This research investigates the effect of intellectual capital on sustainable growth and investigates the moderating role of green innovation strategy in the relationship between intellectual capital and sustainable growth. This research collected 20 companies based on purposive sampling of all non-financial companies on the Indonesia Stock Exchange (IDX) period 2017-2020. The results show that intellectual capital has a negative and significant effect on sustainable growth. The findings also show that green innovation strategy is able to moderate the relationship between intellectual capital and sustainable growth. This research recommends positive values ​​in the green innovation strategy to control intellectual capital in order not to threaten the company's sustainability.
THE EFFECT OF ORGANIZATIONAL CULTURE, INTERNAL AUDIT, AND WHISTLEBLOWING SYSTEM ON FRAUD PREVENTION DURING THE COVID-19 PANDEMIC AT PT DWIMANUNGGAL KARYA INDONESIA
Authors: Awanis Lainun , Rini Dina Dwi Oktavia
Published: September 2023

This study aims to determine the effect of organizational culture, internal audit, and whistleblowing system on fraud prevention during the covid-19 pandemic at PT Dwimanunggal Karya Indonesia Sidoarjo. The method used in this research is quantitative method with primary data obtained from the distribution of questionnaires measured using a likert scale. This study uses a saturated sampling technique so that the entire population is used as a research sample with a total of 40 company’s employees as respondents. The analytical method used in this study is multiple linear regression analysis and the program used to analyze the data is using SPSS Statistics 26. The results show that organizational culture has no effect on fraud prevention during the covid-19 pandemic, internal audit has no effect on fraud prevention during the covid-19 pandemic, while the whistleblowing system has an effect on fraud prevention during the covid-19 pandemic.
OPTIMAL USING PORTFOLIO DIVERSIFICATION MULTI AGENT METHOD IN THE CAPITAL MARKET
Authors: Jaya Asri , Alnur Fitri Handayani , Muchran Muchriana
Published: September 2023

This study aims to apply the multi agent method in order to help investorspredict stock prices by reducing risk when investing. This is based on the behaviorof investors when making decisions in investing in the capital market in consideringthe risks that my occur if they do not manage their portpolios properly. It is knowthat there are 3 papular indicators associated with the multi agent method namelySMA, RSI, dan BB which are used to find out recommendations for stocks to beinvested. Based on the multi agent method, with a population of shares listed inthe LQ-45 index in the period 2019 tp 2021, and sample selection using thepurposive sampling by obtaining 38 samples of stocks with secondary dataobtained from stocks that consistently always exist in the LQ-45 index in the studyperiod totaling 12 samples. The results of the study indicate that there are 3 stocksthat have good portpolios and are also not good for investment. The 3 shares,namely BTPS, BBTN have recommended shares for sale. While ADRO has goodstock recommendations to buy and can be proven by opening tha profitsapplication so that the final results made are real and can be proven.
Tax Morality Moderates Self Assessment System and Money Ethics on Tax Evasion Measures at KPP Pratama Makassar Selatan
Authors: Azhar Fahria , Tenriwaru Tenriwaru , Arifin Arifin
Published: September 2023

The purpose of this research is to examine the relationship between the Self Assessment System Money Ethics and Tax Morality in relation to Tax Evasion at the South Makassar Primary Tax Office. The population in this study consists of individual taxpayers registered at the South Makassar Primary Tax Office, totaling 159,626 individual taxpayers. The sample size for this study was determined using the Slovin formula, resulting in a sample of 100 taxpayers. This study employs a field research method. The statistical method used to test hypotheses involves the use of the partial least square (PLS) approach. The results of the analysis indicate that self assessment system and money ethics simultaneously have a positive and significant influence on tax evasion, while morality as a moderator weakens the impact of self assessment system and money ethics on tax evasion. Recommendations from this study include: 1) for future researchers, it is suggested to include more other independent variables that could influence tax evasion behavior. 2) future researchers are encouraged to use additional data analysis tools. 3) future studies are expected to have a broader range of respondents in their sampling.
Rancang Bangun dan Pengaruh Susunan Pisau Setengah Helix pada Mesin Pencacah Limbah Sayur
Authors: Nugraha Nurcahya , Pramana Tunggul
Published: September 2023

Limbah sayur adalah sisa sayuran yang layu dan membusuk. Biasanya limbah sayur cenderung hanya menjadi sampah yang berujung di tempat pembuangan. Sampah-sampah tersebut masih mengandung kadar air yang tinggi dan memiliki potensi untuk dimanfaatkan sebagai pakan ternak atau pupuk kompos. Namun terdapat kendala dalam pemanfaatannya, kendala utama dalam pemanfaatan limbah sayur yang akan dijadikan sebagai pakan ternak adalah ukuran limbah sayur yang masih cenderung terlalu besar sehingga tidak dapat dimanfaatkan langsung sebagai pakan ternak. Oleh karena itu, diperlukan teknologi yang dapat mempermudah proses pencacahan. Salah satu teknologi pencacah yang tepat untuk memanfaatkan limbah sayur adalah mesin pencacah limbah sayur. Mesin pencacah limbah sayur dirancang menggunakan poros horizontal dan digerakkan oleh motor listrik AC dengan daya 1 hp. Digunakan mekanisme pulley dan belt untuk mereduksi putaran dan mentransmisikan daya dari motor ke pisau pencacah. Pada mesin pencacah ini digunakan susunan pisau setengah helix dan susunan sejajar. Pada mesin ini dilakukan pengujian untuk mengetahui kelebihan pemilihan pola susunan pisau setengah helix dibandingkan dengan pola susunan pisau sejajar, serta untuk mengetahui kapasitas pencacahan yang dimiliki oleh mesin. Pada penelitian ini dilakukan percobaan menggunakan kecepatan putar 1800 rpm. Mesin pencacah dengan susunan pisau setengah helix memiliki kapasitas pencacahan sebesar 231,4 kg/jam, lebih besar dibandingkan dengan susunan pisau sejajar.

Kata kunci: mesin pencacah, limbah sayur, pisau helix
Modern possibilities of pharmacotherapy in a patient with type 2 diabetes mellitus in combination with chronic heart failure
Authors: Voronenko O.S. , Brynza M.S. , Kolomytseva I.M.
Published: September 2023

To analyze the pharmacotherapy of patients with heart failure (HF) who have undergone implantation of a pacemaker, depending on the presence of concomitant type 2 diabetes mellitus (DM) and the effectiveness of implantation. A retrospective analysis of prescriptions for 203 patients with HF who had pacemaker implants was performed using frequency analysis. Pacemaker implantation was considered successful in terms of an increase in the end-diastolic volume of the left ventricle by 15% after 12 months after operation. Before and after implantation of pacemakers, patients received angiotensin-converting enzyme inhibitors, renin-angiotensin blockers, anti-arrhythmic drugs, diuretics, statins, antiplatelet / anticoagulants. A good response to pacemaker implantation made it possible to reduce the need for prescribing diuretics, antiarrhythmics, and to reduce the daily dose of diuretics. Prescribing dapagliflozin to compensate for the level of glycemia was associated with more frequent achievement of a good response to pacemaker, improvement in the course of heart failure. The main directions of pharmacotherapy of patients with HF who have undergone pacemaker implantation meet modem requirements. The additional prescription of secondary metabolic dmgs with unproven efficacy leads to polypharmacy, a decrease of dmgs prescriptions with proven efficacy.

Keywords: heart failure, pacemaker, diabetes mellitus, pharmacotherapy, dapagliflozin.
Kalabalık Yönetimi: Sportif Karşılaşmalarda (Futbol) Meydana Gelen İzdihamlar Üzerine Bir Literatür Taraması
Authors: SAĞ KARA Fulya , YILDIRIM Gül Özlem
Published: September 2023

Dünyada futbol maçları başta olmak üzere toplu olarak gerçekleşen tüm sportif karşılaşmalarda, aşırı kalabalığın yol açtığı izdiham başta olmak üzere yangınlar, şiddet, terörizm gibi birçok tehlikeli durum yaşanmakta ve sonucunda da çok sayıda insan yaralanmakta ya da hayatını kaybetmektedir. Bu çalışmada yöntem olarak konu ile ilgili yapılmış çalışmalar taranmış ve uluslararası bir veri tabanı olan EM-DAT’tan çalışmanın verileri alınmıştır. Bu veriler 1900-2023 yılları arasında “futbol, stadyum ve futbol stadyumu” anahtar kelimeleri ile sınırlandırılmış ve futbol stadyumlarında meydana gelen karşılaşmalarda yaşanan olaylar ile toplam ölümler ve etkilenenlerle ilgili bilgiye yer verilmiştir. Sonuç olarak geçmişten günümüze kadar stadyumlarda futbol karşılaşmaları sırasında kalabalığa bağlı olarak çok fazla sayıda izdiham yaşanmıştır. Futbol stadyumları insanların eğlence amaçlı bulundukları yerler olduğundan dolayı, futbol karşılaşmasının gerçekleştiği stadyumlarındaki risklerin ortaya koyulabilmesi oldukça önemlidir. Kalabalık olarak gerçekleşen tüm etkinliklerde kalabalığın güvenli bir şekilde yönetilebilmesi için, kalabalık yönetim planı oluşturulmalıdır. Kalabalık yönetim planının oluşturulması ile kalabalıktan kaynaklanan risklerin yönetilmesi sağlanacaktır.
Pengaruh Brand Personality terhadap Loyalitas Nasabah Pengguna Aplikasi LIVIN by MANDIRI pada PT BANK MANDIRI (PERSERO) TBK
Authors: Pracoyo Antyo , Malona Cecilia
Published: September 2023

The purpose of this research is to determine the dimension of Responsibility, Agility, Courage, Simplicity, and Emotionally on Brand Personality which have a significant influence on customer loyalty using Livin by Mandiri application at PT. Bank Mandiri (Persero) Tbk. Data obtained from 241 respondents who are customers of PT. Bank Mandiri (Persero) Tbk. The results show that from 5 variables there are 3 of them that give a positive influence and 2 other variables do not have an effect on customer loyalty. The Responsibility variable, Courage variable, and Emotionaly variable have a positive influence on customer loyalty, while the Agility variable and Simplicity variable have no positive effect on customer loyalty.