bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic search for photoacoustic marker using automated transrectal ultrasound
Authors: Wu Zijian , Moradi Hamid , Yang Shuojue , Song Hyunwoo , Boctor Emad M. , Salcudean Septimiu E.
Published: October 2023

Real-time transrectal ultrasound (TRUS) image guidance during robot-assisted laparoscopic radical prostatectomy has the potential to enhance surgery outcomes. Whether conventional or photoacoustic TRUS is used, the robotic system and the TRUS must be registered to each other. Accurate registration can be performed using photoacoustic (PA markers). However, this requires a manual search by an assistant [IEEE Robot. Autom. Lett 8, 1287 (2023).10.1109/LRA.2022.3191788]. This paper introduces the first automatic search for PA markers using a transrectal ultrasound robot. This effectively reduces the challenges associated with the da Vinci-TRUS registration. This paper investigated the performance of three search algorithms in simulation and experiment: Weighted Average (WA), Golden Section Search (GSS), and Ternary Search (TS). For validation, a surgical prostate scenario was mimicked and various ex vivo tissues were tested. As a result, the WA algorithm can achieve 0.53°±0.30° average error after 9 data acquisitions, while the TS and GSS algorithm can achieve 0.29∘±0.31∘ and 0.48°±0.32° average errors after 28 data acquisitions.
Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling
Authors: Padilla-Banks Elizabeth , Jefferson Wendy N. , Papas Brian N. , Suen Alisa A. , Xu Xin , Carreon Diana V. , Willson Cynthia J. , Quist Erin M. , Williams Carmen J.
Published: October 2023

Tissue development entails genetically programmed differentiation of immature cell types to mature, fully differentiated cells. Exposure during development to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of endometrial adenocarcinoma that results from brief developmental exposure to an estrogenic chemical, diethylstilbestrol (DES), to determine causative factors. Single-cell RNA sequencing (scRNAseq) and spatial transcriptomics of adult control uteri revealed novel markers of uterine epithelial stem cells (EpSCs), identified distinct luminal and glandular progenitor cell (PC) populations, and defined glandular and luminal epithelium (LE) cell differentiation trajectories. Neonatal DES exposure disrupted uterine epithelial cell differentiation, resulting in a failure to generate an EpSC population or distinguishable glandular and luminal progenitors or mature cells. Instead, the DES-exposed epithelial cells were characterized by a single proliferating PC population and widespread activation of Wnt/β-catenin signaling. The underlying endometrial stromal cells had dramatic increases in inflammatory signaling pathways and oxidative stress. Together, these changes activated phosphoinositide 3-kinase/AKT serine-threonine kinase signaling and malignant transformation of cells that were marked by phospho-AKT and the cancer-associated protein olfactomedin 4. Here, we defined a mechanistic pathway from developmental exposure to an endocrine disrupting chemical to the development of adult-onset cancer. These findings provide an explanation for how human cancers, which are often associated with abnormal activation of PI3K/AKT signaling, could result from exposure to environmental insults during development.
Identification of the regulatory circuit governing corneal epithelial fate determination and disease
Authors: Smits Jos G. A. , Cunha Dulce Lima , Amini Maryam , Bertolin Marina , Laberthonnière Camille , Qu Jieqiong , Owen Nicholas , Latta Lorenz , Seitz Berthold , Roux Lauriane N. , Stachon Tanja , Ferrari Stefano , Moosajee Mariya , Aberdam Daniel , Szentmary Nora , van Heeringen Simon J. , Zhou Huiqing
Published: October 2023

The transparent corneal epithelium in the eye is maintained through the homeostasis regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on epidermal keratinocytes for renewal. Despite their cellular similarities, the precise cell fates of these two types of epithelial stem cells, which give rise to functionally distinct epithelia, remain unknown. We performed a multi-omics analysis of human LSCs from the cornea and keratinocytes from the epidermis and characterized their molecular signatures, highlighting their similarities and differences. Through gene regulatory network analyses, we identified shared and cell type-specific transcription factors (TFs) that define specific cell fates and established their regulatory hierarchy. Single-cell RNA-seq (scRNA-seq) analyses of the cornea and the epidermis confirmed these shared and cell type-specific TFs. Notably, the shared and LSC-specific TFs can cooperatively target genes associated with corneal opacity. Importantly, we discovered that FOSL2, a direct PAX6 target gene, is a novel candidate associated with corneal opacity, and it regulates genes implicated in corneal diseases. By characterizing molecular signatures, our study unveils the regulatory circuitry governing the LSC fate and its association with corneal opacity.
Integration of pan-cancer multi-omics data for novel mixed subgroup identification using machine learning methods
Authors: Khadirnaikar Seema , Shukla Sudhanshu , Prasanna S. R. M.
Published: October 2023

Cancer is a heterogeneous disease, and patients with tumors from different organs can share similar epigenetic and genetic alterations. Therefore, it is crucial to identify the novel subgroups of patients with similar molecular characteristics. It is possible to propose a better treatment strategy when the heterogeneity of the patient is accounted for during subgroup identification, irrespective of the tissue of origin. This work proposes a machine learning (ML) based pipeline for subgroup identification in pan-cancer. Here, mRNA, miRNA, DNA methylation, and protein expression features from pan-cancer samples were concatenated and non-linearly projected to a lower dimension using an ML algorithm. This data was then clustered to identify multi-omics-based novel subgroups. The clinical characterization of these ML subgroups indicated significant differences in overall survival (OS) and disease-free survival (DFS) (p-value<0.0001). The subgroups formed by the patients from different tumors shared similar molecular alterations in terms of immune microenvironment, mutation profile, and enriched pathways. Further, decision-level and feature-level fused classification models were built to identify the novel subgroups for unseen samples. Additionally, the classification models were used to obtain the class labels for the validation samples, and the molecular characteristics were verified. To summarize, this work identified novel ML subgroups using multi-omics data and showed that the patients with different tumor types could be similar molecularly. We also proposed and validated the classification models for subgroup identification. The proposed classification models can be used to identify the novel multi-omics subgroups, and the molecular characteristics of each subgroup can be used to design appropriate treatment regimen.
Measurement of radioactivity in soils of Karamjal and Harbaria mangrove forest of Sundarbans for establishment of radiological database
Authors: Siraz M. M. Mahfuz , A. M. Jubair , Alam M. S. , Rashid Md. Bazlar , Hossain Z. , Khandaker Mayeen Uddin , Bradley D. A. , Yeasmin S.
Published: October 2023

This work presents the first in-depth study of soil radioactivity in the mangrove forest of Bangladesh part of the Sundarbans. It used HPGe gamma-ray spectrometry to measure the amount of natural radioactivity in soil samples from Karamjal and Harbaria sites of the world’s largest mangrove forest. The activity concentrations of most of the 226Ra (14±2 Bqkg-1 to 35±4 Bqkg-1) and 232Th (30±5 Bqkg-1 to 50±9 Bqkg-1) lie within the world average values, but the 40K concentration (370± 44 Bqkg-1 to 660±72 Bqkg-1) was found to have exceeded the world average value. The evaluation of radiological hazard parameters revealed that the outdoor absorbed dose rate (maximum 73.25 nGyh-1) and outdoor annual effective dose (maximum 0.09 mSvy-1) for most samples exceeded the corresponding world average values. The elevated concentration of 40K is mainly due to the salinity intrusion, usage of fertilizers and agricultural runoff, and migration of waste effluents along the riverbanks. Being the pioneering comprehensive research on the Bangladesh side of the Sundarbans, this study forms a baseline radioactivity for the Sundarbans before the commissioning of the Rooppur Nuclear Power Plant in Bangladesh.
Placental characteristics and neonatal weights among women with malaria-preeclampsia comorbidity and healthy pregnancies
Authors: Lwamulungi Everett , Qureshi Zahida , Obimbo Moses , Ogutu Omondi , Cheserem Eunice , Kosgei Rose J. , Walong Edwin , Inyangala Dennis , Nyakundi George G. , Ndavi Patrick M. , Osoti Alfred O. , Ondieki Diana K. , Pulei Anne N. , Njoroge Anne , Masyuko Sarah , Wachira Cyrus M.
Published: October 2023

Background

Malaria and preeclampsia are leading causes of maternal morbidity and mortality in sub-Saharan Africa. They contribute significantly to poor perinatal outcomes like low neonatal weight by causing considerable placental morphological changes that impair placental function. Previous studies have described the effects of either condition on the placental structure but the structure of the placenta in malaria-preeclampsia comorbidity is largely understudied despite its high burden. This study aimed to compare the placental characteristics and neonatal weights among women with malaria-preeclampsia comorbidity versus those with healthy pregnancies.

Methodology

We conducted a retrospective cohort study among 24 women with malaria-preeclampsia comorbidity and 24 women with healthy pregnancies at a County Hospital in Western Kenya. Neonatal weights, gross and histo-morphometric placental characteristics were compared among the two groups.

Results

There was a significant reduction in neonatal weights (P<0.001), placental weights (P = 0.028), cord length (P<0.001), and cord diameter (P<0.001) among women with malaria-preeclampsia comorbidity compared to those with healthy pregnancies. There was also a significant reduction in villous maturity (P = 0.016) and villous volume density (P = 0.012) with increased villous vascularity (P<0.007) among women with malaria-preeclampsia comorbidity compared to those with healthy pregnancies.

Conclusion

Placental villous maturity and villous volume density are significantly reduced in patients with malaria-preeclampsia comorbidity with a compensatory increase in villous vascularity. This leads to impaired placental function that contributes to lower neonatal weights.
Integrated care in patients with atrial fibrillation- a predictive heterogeneous treatment effect analysis of the ALL-IN trial
Authors: Trinks-Roerdink Emmy M. , Geersing Geert-Jan , van den Dries Carline J. , Hemels Martin E. W. , Rienstra Michiel , van Gelder Isabelle C. , van Smeden Maarten , van Klaveren David , Kent David M. , Rutten Frans H. , van Doorn Sander
Published: October 2023

Introduction

Integrated care is effective in reducing all-cause mortality in patients with atrial fibrillation (AF) in primary care, though time and resource intensive. The aim of the current study was to assess whether integrated care should be directed at all AF patients equally.

Methods

The ALL-IN trial (n = 1,240 patients, median age 77 years) was a cluster-randomized trial in which primary care practices were randomized to provide integrated care or usual care to AF patients aged 65 years and older. Integrated care comprised of (i) anticoagulation monitoring, (ii) quarterly checkups and (iii) easy-access consultation with cardiologists. For the current analysis, cox proportional hazard analysis with all clinical variables from the CHA2DS2-VASc score was used to predict all-cause mortality in the ALL-IN trial. Subsequently, the hazard ratio and absolute risk reduction were plotted as a function of this predicted mortality risk to explore treatment heterogeneity.

Results

Under usual care, after a median of 2 years follow-up the absolute risk of all-cause mortality in the highest-risk quarter was 31.0%, compared to 4.6% in the lowest-risk quarter. On the relative scale, there was no evidence of treatment heterogeneity (p for interaction = 0.90). However, there was substantial treatment heterogeneity on the absolute scale: risk reduction in the lowest risk- quarter of risk 3.3% (95% CI -0.4% - 7.0) compared to 12.0% (95% CI 2.7% - 22.0) in the highest risk quarter.

Conclusion

While the relative degree of benefit from integrated AF care is similar in all patients, patients with a high all-cause mortality risk have a greater benefit on an absolute scale and should therefore be prioritized when implementing integrated care.
Seasonal and environmental dynamics of intra-urban freshwater habitats and their influence on the abundance of Bulinus snail host of Schistosoma haematobium in the Tiko endemic focus, Mount Cameroon region
Authors: Wepnje Godlove Bunda , Peters Marcell K. , Green Adeline Enjema , Nkuizin Tingmi Emparo , Kenko Daniel Brice Nkontcheu , Dzekashu Fairo F. , Kimbi Helen Kuokuo , Anchang-Kimbi Judith Kuoh
Published: October 2023

Urogenital schistosomiasis (UGS) caused by Schistosoma haematobium is endemic in the South West Region of Cameroon. An understanding of the abundance and distribution of the Bulinus snail, intermediate host can inform strategic snail control programmes at a local scale. This study investigated seasonal dynamics and environmental factors influencing occurrence and abundance of freshwater snail intermediate hosts in Tiko, a semi-urban endemic focus in the Mount Cameroon area. A longitudinal malacological field survey was conducted between December 2019 and December 2020 in the Tiko municipality. Snails were collected for one year monthly at 12 different human water contact sites along a stretch of the Ndongo stream using a standardized sampling technique. Freshwater snails were identified using shell morphological features. In addition, water temperature, pH, electrical conductivity, total dissolved solutes, salinity, water depth, width and flow velocity were measured, and vegetation cover as well as substrate type were determined. Bayesian regression models were used to identify the main environmental factors affecting the occurrence and abundance of Bulinus intermediate host. In total, 2129 fresh water snails were collected during the study period. Physa (51.4%) was the most abundant genus followed by Melanoides (28.6%) then, Bulinus (15.5%), Lymnaea (4.2%), Indoplanorbis (0.2%) and Potadoma (0.1%). Seasonality in abundance was significant in Bulinus sp as well as other genera, with greater numbers in the dry season (peaks between December and February). Water temperature, a rocky or sandy substrate type associated positively with Bulinus sp, meanwhile a higher water flow rate and medium vegetation negatively influenced the snail intermediate host population. These findings underscore the importance of timing behavioural and snail control interventions against schistosomiasis as well as increase vigilance of other trematode diseases in the study area. The continuous spread of planorbid snail hosts is a major concern.
The prevalence of age-related macular degeneration and osteoporosis in the older Polish population: Is there a link?
Authors: Budnik Agnieszka , Palewski Marcin , Michnowska-Kobylińska Magdalena , Lisowski Łukasz , Łapińska Magda , Stachurska Zofia , Szpakowicz Anna , Konstantynowicz Jerzy , Kamiński Karol , Konopińska Joanna
Published: October 2023

Background

Age-related macular degeneration is the primary cause of irreversible blindness in developed countries, whereas the global prevalence of osteoporosis–a major public health problem–is 19.7%. Both diseases may coincide in populations aged >50 years, leading to serious health deterioration and decreased quality of life.

Objectives

This study aimed to analyze the relationship between age-related macular degeneration and osteopenia, defined as decreased bone mineral density, in the Polish population.

Methods

Participants were derived from the population-based Bialystok PLUS Study. Randomized individuals were stratified into two groups, those with age-related macular degeneration (AMD-1 group) or without age-related macular degeneration (AMD-0 group). Using a cutoff value of −1.0 to identify low bone mass, participants with femoral bone mineral density T-scores above −1.0 were assigned to the normal reference, and those with T-scores below −1.0 were assigned to the osteopenia category. Among 436 Caucasian participants aged 50–80 years (252 women, 184 men), the prevalence of age-related macular degeneration was 9.9% in women and 12.0% in men. Decreased bone mineral density based on T-scores was observed in 36.9% of women and in 18.9% of men. Significant differences in femoral bone mineral density between the AMD-0 and AMD-1 groups were detected only in men (mean difference [95% confidence interval] = 0.11 (0.02; 0.13); p = 0.012 for femoral bone mineral density, and 0.73 [0.015; 0.94]; p = 0.011 for the femoral T-score). No associations were observed between bone mineral density and age-related macular degeneration in women.

Conclusion

Decreased femoral bone mineral density may be associated with a higher risk of age-related macular degeneration in men, but a causal link remains unclear.
Metastatic Colon Cancer Presenting as Gallbladder Perforation: Highlighting the Diagnostic Challenges and Clinical Implications
Authors: Nagpal Sagar , Khattak Taif , Pokhriyal Sindhu C. , Nisar Salma , Daoud Amro , Goenka Puneet
Published: October 2023

Gallbladder perforation is an uncommon occurrence that demands prompt surgical intervention, typically observed in the context of acute cholecystitis. In this article, we present an extraordinary case of gallbladder gangrene and perforation, originating from metastasis of colon cancer. The patient's presentation included an incidental discovery of colon cancer, which was indicated by histopathology of the gall bladder. This case report aims to shed light on the intricate relationship between gallbladder pathology and metastatic colon cancer, emphasizing the need for vigilant evaluation and comprehensive management strategies.
Shades, Voice and Mobility: Afar pastoralist and Rift Valley communities (re)interpreting literacy and linguistic practices
Authors: Heugh Kathleen
Published: October 2023

In this paper, narrative data from remote communities in Ethiopia reveal in intimate ways how ‘linguistic citizenship’ (Stroud 2001) is claimed and exercised to resist educational decisions which are insensitive to the rhythms of pastoral or rural life. Even where communities are distant from the discourses and resources of the centre, individuals and community spokespersons express powerful views which resonate with contemporary global and local concerns of linguistic diversity, literacy and migration. While conventional representations suggest that such communities lack agency and voice, are require externally delivered aid and to be ‘spoken for’, this article reveals a matrix of articulate positions on language/s, literacy/ies and participation in both primary school and adult education. Amongst the challenges of (re)interpretation for the researcher is a discordant intersection of fluid temporal and spatial positions of researcher and respondent, simultaneously translocal and transnational. Agitated shifts in time and space recast shades and voice for both respondent and researcher. This paper raises questions for research procedures and interpretation of narrative accounts of literacy(ies), linguistics and educational practices on the margins. In particular, the discussion suggests that an understanding of and sensitivity towards the linguistic citizenship of informants as well as the multilayered positions of the researcher, including the researcher’s own linguistic citizenship, offer productive theoretical and methodological approaches to ethnographic research.
Il com(pro)messo fiorentino, ou la bottega comme espace de négociations
Authors: Cindrić Lola
Published: October 2023

Jusqu’en 1806, la production en marqueterie de pierres à Florence – la capi- tale historique de cet artisanat pour l’Europe – était le monopole de la manufacture grand-ducale fondée en 1588 par Ferdinand I er de Médicis. Mais à la levée de cette res- triction, un réseau d’ateliers indépendants initié par d’anciens employés de la manufac- ture se développa tout au long du siècle et perdure encore aujourd’hui. Dépourvus de mécènes et contraints par la nécessité de s’auto-financer, ces ateliers xsprivés (appelés botteghe) ont dû adapter la pratique de leur artisanat et les manières de le promouvoir pour le rendre rentable. Les artisans recourent alors à des négociations entre ce qui faisait jusqu’ici les canons de leur art et les exigences du marché dans lequel ils doivent s’insérer. Cet article propose d’analyser ces choix d’ordre technique, commeWrcial et rhétorique qui ont conditionné la production en marqueterie de pierres à Florence tout au long du XIXe siècle.
Phytochemical Screening and Evaluation of Antioxidant, Antidiabetic, and Antimicrobial Potential of Bergenia ligulata
Authors: Rani Sushila , Puri Richa , Boora Pooja , Qasim Abul
Published: October 2023

Bergenia ligulata, locally known as “Pashanbheda,” belongs to the family Saxifragaceae and is a perennial herb with a short and thick stem. This plant has numerous medicinal properties including antioxidant, antidiabetic, antibacterial, and anti-inflammatory properties. The qualitative and quantitative analysis shows that the rhizome of this plant contains various phytochemical constituents. Qualitative analysis shows that it contains phenols, flavonoids, tannins, terpenoids, alkaloids, steroids, carbohydrates, and glycosides. Thirty- two bioactive compounds were identifiedduring GC-MS analysis. Dihydro-3-methylene-5-methyl-2-furanon, Stigmast-5-en-3-ol, 9-Octadecenamide(Z), 6,9-Octadecadienoic acid, methyl ester, 9,12-Octadecadienoic acid (Z, Z)-, methyl compounds have antioxidant, antibacterial and anti-inflammatory activities. The total phenol and flavonoid content from the quantitative analysis revealed a significant amount of phenol i.e., 67.1±0.02*6mg/g, and flavonoid content i.e., 89.11±0.01* mg/g. In vitro, antioxidant activities were estimated by diphenyl-1-picrylhydrazyl assay showing the highest % inhibition of 47.24±0.06* for plant extract and 41.63±0.057* for standard respectively. The in vitro, antidiabetic activitieswere estimated by alpha-amylase inhibition assay showing the highest % inhibition of 67.14±0.05* at 250 μg/ ml for methanolic plant extract and 61.42±0.01* at 250 μg/ ml for standard and in vitro antibacterial potential were detected by using Agar well diffusion process. The anti-bacterial action was found maximum in aqueous plant extract against staphylococcus aureus bacteria.
Organic Farming in India and its Way Forward
Authors: Krithika N , Jain Rishabh , Sharma Monika , Mishra Rajeev Kumar
Published: October 2023

India is home to 30% of the world’s organic growers and is likely to expand in the coming years. The solutionto the issues of sustainability, global warming, land degradation and food security is Organic Farming, which is seen as a sign of dynamic change for the agricultural industry. Organic Farming discards the use of synthetic fertilizers and promotes sustainable agricultural practices. Organic Farming holds immense potential to revive the degrading state of the agricultural sector in the world by offering environmental benefits, quality products and conserving non-renewable resources. It is a promising alternative to conventional farming and is expanding quickly. Organic Farming is gaining worldwide attention with 2.30 million hectares of land being used for the purpose. It helps to reduce greenhouse gas (GHG) emissions and improves soil fertility, boosting productivity and crop health. Organic Farming can also be used for land reclamation purposes. The aim of the present study is to examine the development of Organic Farming in India and globally, as well as identify any potential barriers to its implementation.
New measurement approaches to identifying spatial concentrations of poor and low-income households in German city regions
Authors: Fina Stefan , Schmitz Julian , Weck Sabine , Pfaffenbach Carmella , Dobusch Diane
Published: October 2023

The question of whether 21st-century urbanization dynamics are leading to a suburbanization of poverty in Western city regions has been on the agenda of spatial researchers and housing policymakers for over a decade now. Persistent reurbanization trends are putting increased pressure on inner-city housing markets, resulting in affordability problems for low-income households. Evidence from the US and the UK shows that financing mechanisms in the real estate sector were severely disrupted in the aftermath of the financial crisis in 2009 and subsequent years, with many households losing their homes and being forced to move. Though social security systems and social housing policies generally have a moderating effect, they vary widely across Western countries. Against this background, this paper presents three spatial observation methods tailored to the spatial analysis of poverty concentrations in Germany. The methods are based on three popular conceptualizations of poverty: material poverty, relative poverty, and the concept of neighbourhood deprivation. The main novelty presented in this paper is a cold-spot analysis of purchasing power in 33 city regions using interactive map visualizations and complemented by socioeconomic indicators. Expert feedback verifies the validity of the approach which addresses a ‘blind spot’ in assessing poverty in Germany, where many low-income households are increasingly exposed to risks of poverty despite not qualifying for social benefits.
THE EFFECT OF COMPETITIVENESS AND EFFICIENCY ON THE ADDED VALUE OF THE COPRA INDUSTRY (ISIC 10421) IN INDONESIA
Authors: APRIANI DEASSY , Putri Gita Yulia , Teguh Muhammad , Robiani Bernadette
Published: October 2023

Industry copra in Indonesia still not yet get attention in a manner specifically by the government so that causing export copra experience that level fluctuate. So from that importance role performance in the industry copra in development a country and for fulfil need society. This study aims to find out the competitiveness, level of efficiency and the influence of competitiveness and efficiency on the added value of the copra industry (ISIC 10421) in Indonesia. The type of data used is secondary data obtained from the Central Statistics Agency and UN  Comtrade related to the copra industry in the 2011-2020 period.  This research, using competitiveness analysis with the Revealed Comparative Advantage method, and multiple linear regression. The results showed that variable competitiveness of Indonesia has the strength of competitiveness and comparative induction in the copra industry, as evidenced by the calculation of the method Revealed Comparative Advantage which has a value of 27.36. The efficiency of the copra industry is fairly inefficient with the average level of efficiency obtained is 0.83. Meanwhile, variable competitiveness and efficiency have a positive and significant effect on the added value of the copra industry.
PERANCANGAN SLAVE ARM-MANIPULATOR ROBOT 6-DOF DENGAN REMOTE CENTER OF MOTION MEKANIK BERBASIS INVERSE KINEMATICS
Authors: Fadzillah Hanafi , Setiawan Iwan , Sumardi Sumardi
Published: October 2023

Penelitian mengenai robot bedah di dalam dunia medis menjadi salah satu penelitian yang cukup populer karena manfaatnya dalam MIS (Minimal Invasive Surgery). Pembedahan ini memungkinkan pasien untuk mengalami sayatan kecil dalam pembedahan sehingga pasien tidak mengalami pendarahan berlebih dan cepat sembuh dari opname. Oleh karena itu, pada penelitian ini dibahas mengenai perancangan manipulator robot 6 DOF (Degree of Freedom) dengan RCM (Remote Center of Motion) Mekanik. RCM mekanik memungkin rod end effector robot bergerak dengan mempertahankan satu titik statis yang di dalam dunia medis disebut trocar point. Dengan adanya RCM ini, beban sistem kendali robot dapat dikurangi dan titik trocar yang didapatkan tetap. Differential inverse kinematics yang memanfaat Matriks Jacobian digunakan sebagai sistem kendali robot. Karena metode differential inverse kinematics merupakan metode yang iteratif, algoritma trajectory planning dirancang untuk menyatu dengan metode inverse kinematic. Posisi end effector yang didapatkan melalui metode kendali ini memiliki error maksimum rata-rata sebesar 36 mm dengan hasil trajectory planning yang halus menyerupai respon sistem orde 1.
PERENCANAAN RANCANGAN KONSTRUKSI DAN JARINGAN DISTRIBUSI 20 KV BARU DI KAWASAN INDUSTRI SEGAYUNG BATANG
Authors: Haryadi Irzi Rifa'i Mufti , Karnoto Karnoto , Santoso Imam
Published: October 2023

Jaringan distribusi tenaga listrik merupakan bagian dari sistem tenaga listrik setelah jaringan transmisi dan sebelum disalurkan ke pelanggan. Seiring pesatnya kemajuan teknologi dan kebutuhan listrik dari berbagai sektor salah satunya sektor industri, membuat pasokan listrik mengalami banyak permintaan. PT. PLN UP3 Pekalongan menerima permintaan dari Kawasan Industri Segayung Batang yang berlokasi di Jalan Raya Bandar-Tulis, Area Sawah, Posong, Kec. Tulis, Kab. Batang, Jawa Tengah. Permintaan kebutuhan listrik dengan daya 20 MW dan dibutuhkan 2 penyulang baru untuk mensuplai daya tersebut. TLS06 dan TLS07 merupakan jaringan baru yang akan direncanakan berdasarkan Standar Perusahaan Listrik Negara (SPLN). Perencanaan jaringan terbagi menjadi dua 2 rute, panjang jaringan rute 1 yaitu ±4900 meter dan panjang jaringan rute 2 yaitu ±6200 meter. Penghantar yang dipakai pada perencanaan jaringan ini menggunakan NFAAXSEY-T mm2 untuk semua rute dan menggunakan tiang beton panjang 14 meter dengan kekuatan tiang 500 daN untuk tiang awal dan 350 daN untuk tiang lainnya. Rute pada perencanaan jaringan distribusi 20 kV yang efisien berdasarkan konstruksi dan biaya yang mengacu pada harga satuan standar (HSS) PT. PLN Distribusi Jawa Tengah dan DIY yaitu rute pengganti 1 dengan biaya investasi sebesar Rp. 4.303.242.550.
Fused filament fabricated PEEK based polymer composites for orthopaedic implants: a review
Authors: Sankar Sathishkumar , Paulraj Jawahar , Chakraborti Prasun
Published: October 2023

Additive manufacturing has become a cutting-edge technique to produce biomaterials for various clinical applications. Recent investigations have shown their significance and highlighted their future requirements. Many additive manufacturing technologies are mostly related to manufacturing polyether ether ketone (PEEK) based implants. Among them, fused filament fabrication (FFF) or fused deposition modelling (FDM) is the preferred method. Specifically, FFF builds complex scaffolds for tissue engineering and customized implants, which are not achievable with traditional fabrication methods. PEEK is a rigid, tissue-compatible, lightweight polymer with good wear characteristics and a long implant life. In general, PEEK has many valuable properties and the potential to solve many medical problems, especially orthopaedic implantation. This paper provides a brief study that gives an overview of PEEK-based biomaterials for FFF-based orthopaedic procedures, materials evolution, recent advancements, and the current research progress is also addressed systematically.
Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
Authors: Thapa Tika Bahadur , Pokhrel Sushant , Lamichhane Anit , Singh Vinay Kumar , Shrestha Ojaswee , Sapkota Manisha , Khanal Puspa Raj
Published: October 2023

Identifying and appropriately managing urinary tract infections (UTIs) among chronic kidney disease (CKD) patients are essential to reduce further disease complications and economic burden. Hence, this study aims to determine the prevalence of UTIs among CKD patients and study the antibiogram of the bacterial isolates. Four hundred eighty-two clean catch midstream urine samples were collected from CKD patients during the study period. The samples were cultured, and bacteria were isolated using standard microbiological techniques. Antibiotic susceptibility testing was performed by the Kirby–Bauer disc diffusion method following the Clinical and Laboratory Standards Institute guidelines. Of the 482 CKD patients, 15.8% were culture positive, and the majority was elderly aged group population. Most bacterial isolates were Escherichia coli 50%, followed by Pseudomonas aeruginosa 15.80%, Enterococcus species 15.80%, and Klebsiella pneumoniae 11.84%. The majority of bacteria were found to be resistant to beta-lactam antibiotics, ampicillin (94.67%), ceftriaxone (89.04%), cefotaxime (87.5%), and ceftazidime (84.0%), while polymyxin, colistin, vancomycin, meropenem, and imipenem were the most sensitive antibiotics. In our study, higher levels of antibiotic resistance were observed among urinary isolates. Therefore, our findings suggest clinicians to choose better antibiotic options to treat UTIs among CKD patients.
Artificial intelligence approach to analyze SIMS profiles of11B,31P and75As in n- and p-type silicon substrates: experimental investigation
Authors: Filali Walid , Boubaaya Mohamed , Garoudja Elyes , Lekoui Fouaz , Abdellaoui Ibrahime , Amrani Rachid , Oussalah Slimane , Sengouga Nouredine
Published: October 2023

In this work, we report an effective approach based on an artificial intelligence technique to investigate the secondary ions mass spectroscopy (SIMS) profiles of boron, phosphorus and arsenic ions. Those dopant ions were implanted into n- and p-type (100) Silicon substrate using the ion implantation technique with energy of 100 and 180 keV. Annealing treatment was conducted at various temperatures ranging from 900 to 1030 °C for 30 min. The doping profile parameters such as the activation energy, diffusion coefficient, junction depth, implant dose, projected range and standard deviation were determined using particle swarm optimization (PSO) algorithm. The efficiency of this strategy was experimentally verified by the fitting between both real measured SIMS profile and predicted ones. In addition, a set of simulated doping profiles was generated for different annealing time to prove the ability of this approach to accurately estimate the above parameters even when changing the experimental conditions.
KI-koordinierte Kollaboration zwischen Mensch und Roboter
Authors: A. Metzler Yannick , Renker Johanna , Zickerick Bianca , Dreger Felix , Karthaus Melanie , Rinkenauer Gerhard
Published: October 2023

In diesem Beitrag werden zusammenfassend erste Erkenntnisse aus dem zurzeit laufenden EU-Horizon Projekt FELICE beschrieben. Am Beispiel einer Montagefertigungslinie werden Technologien entwickelt, um die Mensch-Roboter-Kollaboration in hochflexiblen Arbeitssystemen mithilfe koordinierender und steuernder Vernetzung durch künstliche Intelligenz effizient und ergonomisch zu gestalten. Außerdem werden Aspekte diskutiert, die es bei der Einführung solcher Systeme in Organisationen aus der Perspektive einer gelungenen Integration aller Stakeholder zu berücksichtigen gilt.
EVANGÉLICOS E POLÍTICA ELEITORAL NA AMÉRICA LATINA
Authors: Oliveira Sávio Silva de
Published: October 2023

Resenha. Em “Evangélicos e Política Eleitoral na América Latina”, Taylor Boas examina a participação eleitoral dos evangélicos na América Latina e o marcante ativismo político que tem moldado a identidade do segmento religioso nos últimos anos.
Democracy in Zuhud Concept: Politics of Articulation of Truth of Gus Mus’ Intelligence Practice in the 2015 NU Congress
Authors: Khoiron Khoiron , Santoso Purwo , Irawanto Budi
Published: October 2023

This study describes intellectuality as a practice of contesting truth in offering alternative truths aside from the existing truth. This paper aimed to describe how the truth regime is articulated by the subject of knowledge and a political agent, namely Ahmad Mustofa Bisri, in the 2015 NU Congress. At that moment, Gus Mus’ practice of articulating truth by refusing the position of ‘rais aam’ was political. This study questioned how the regime of truth was articulated amid the power contest at the 2015 NU Congress. This study argued that, amid the practice of contesting truth, at the same time, there is a politics of value and idea articulation carried out by an individual who occupies a position as part of the intellectual. It is at the political level of the articulation of truth that novelty is described in this study. This study produced truths using text and context-based discourse analysis methods, including: 1). dismissing ‘hubbud dunya’, 2). fostering ‘mind’ and ‘morality’, and 3). it is strengthening ‘legawing ati’ in dedication. In contrast, the above markers are marker moments that reinforcer the primary marker, namely the regime of zuhud, articulated by Gus Mus by self-regulation (subject position) as ‘ a student’ related to elements of discourse antagonism—the term of ‘kiai’ related to the position of rais aam.
Research Trend on E-democracy Publications: A Bibliometric Analysis
Authors: Syahputri Gusti Chairunnisa Adinda , Suhermanto Dedik Fitra , Roziqin Ali , Nafi'ah Binti Azizatun
Published: October 2023

The e-democracy system that continues to change and develop every year is an exciting topic to continue to be studied. Since the massive development of information and communication technology, research related to e-democracy is now a trend carried out by scholars. The article aims to evaluate the e-democracy research trend through bibliometric analysis techniques in two decades (2001-2020). This article uses a bibliometric analysis with applied VOSviewer to provide researchers with describing data and Gephy software to map network classification. Countries in Europe and the Americas dominate the research and implementation of the e-democracy system through a smaller approach, namely, e-government. This article found nine main clusters of 306 articles that have been coming from different countries, affiliates, and authors. This clusterization mapping was helpful for future researchers in developing and discussing their research on the study of e-democracy.
Political Parties and Women’s Representation in the Indonesian Parliament 2009-2019
Authors: Ruriana Alvinda Putri , Fahadayna Adhi Cahya , Tawakkal George Towar Ikbal
Published: October 2023

As the transmission belt linking people's aspirations to the government, the political party has a crucial role in preparing actors to become candidates for people's representatives. Since the enactment of affirmative policies both in elections and internal parties, the number of women in parliament has never met the 30% quota as expected. During the ten years from 2009 to 2019, the number of women in the House of Representatives (Dewan Perwakilan Rakyat, DPR) seats only ranged from 17-20 percent. This article examines the influence of political parties' characteristics on women's representation in the Indonesian parliament in the 2009-2019 period. This research uses four party characteristics by Sundström Stockemer as variables that will be analyzed through linear regression models. The research results show that the vote size variable is the only variable significantly influencing women's representation in parliament. The estimated trend of women's representation in parliament shows an increase in the upcoming 2024 elections. However, it is still far from the target of 30%. Hence, it needs a progressive affirmative policy in the form of reserved seats to encourage proportionality in the policy-making forum.
Reproductive Justice-Informed Care for Stis, Contraception, and Abortion in Pediatrics
Authors: Karbeah J’Mag , Hassan Asha , Hardeman Rachel
Published: October 2023

As comprehensive contraceptive counseling has become the standard of care within pediatrics, new questions and concerns about patients’ ages and abilities to make reproductive choices have arisen. It is important for pediatric health professionals, who often shape individuals’ relationships with the health care system throughout their life course, to understand how racism affects the reproductive and sexual health care experience of minoritized youth. The reproductive justice framework highlights the necessity for reproductive autonomy for adolescents and emerging adults and aligns with the idea of bodily autonomy that pediatric health professionals already recognize. However, connecting the need for bodily autonomy with understanding the impacts of historical and current racialized coercion, exploitation, and disenfranchisement on health care delivery is necessary.

Keywords: reproductive justice, sexual and reproductive health, contraceptive care
The Role of Racism in Child and Adolescent Injuries
Authors: Hoffman Benjamin D.
Published: October 2023

Unintentional injuries are the leading cause of youth mortality in the United States, with an average of more than 6,000 children and youth between the ages of 1 and 18 dying annually. Although pediatric health professionals have noted improvement in some areas, such as infant sleep-related death and motor-vehicle occupant fatalities, the injury epidemic persists. As with many epidemics, the risk is more significant for minoritized communities, often resulting from structural inequity and racism.

Keywords: unintentional injury, racism, youth
The Impact of Interactions with Law Enforcement On the Health of Racially Minoritized Youth
Authors: Jindal Monique , Corley Alexandra M. S.
Published: October 2023

Police contact is a critical determinant of health. Racial disparities persist in police contact, resulting in health inequities for people from minoritized groups, including death. Children and adolescents are not exempt from interactions with the police because they may be secondarily exposed to law enforcement through their caregivers, passively surveilled within their neighborhoods, and even directly subjected to contact with border patrol agents, school resource officers, and community police. Pediatric and adolescent health professionals should be well versed in policing as a potential source of trauma for children, adolescents, and their families. They should advocate for evidence-based interventions that reduce exposure to police contact.

Keywords: police contact, law enforcement, trauma
Social Determinants of Health and the Invisible Ubiquity of Racism: A Driving Force of Health Inequities and the Way Forward
Authors: Thornton Rachel L. J.
Published: October 2023

Pediatric clinical and population health efforts are increasingly focused on the social determinants of health, the political, economic, social, and environmental conditions in which children grow, learn, live, and play, which can lead to lifelong impacts on health and well-being. For pediatric health professionals seeking to advance child health equity, understanding disparate social conditions within the context of racism as a structural force is critical. This chapter examines how health care delivery, medical education, access to economic opportunity, and essential goods and services are distributed in our local communities, states, and nation. Equipped with this knowledge, pediatric health professionals can address urgent unmet social needs among their patient populations.

Keywords: child health equity, social determinants of health, racism, health
Pediatric and Adolescent Research On Race and Racism
Authors: Coyne-Beasley Tamera , Svetaz María Verónica
Published: October 2023

The increase in hate crimes over the past decade, combined with centuries of social and racial injustice, has catalyzed an urgency for scientists to examine what the authors describe as the racism research gap: the unacceptable lack of research on effective interventions and best practices to promote resiliency and address racism as a social determinant of health (SDOH), an adverse childhood experience, and a source of chronic stress among children and adolescents. Scientific research will be critical for developing evidence-based effective interventions to mitigate the impacts of racism and its resultant health disparities. More importantly, dismantling racism will require a comprehensive, multi-sector, interdisciplinary, and life course approach across all levels of the socio-ecological framework with a focus on the SDOH.

Keywords: adolescent, research, racism
The Effect of ESG on Customer Attitude: A Focus on the Mediation Effect of Sustainability
Authors:   The Korea International Trade Research Institute, An Chang-Hyun
Published: October 2023

Purpose - The purpose of this study is to analyze the mediating effect of sustainability in the relationship between ESG and customer attitude.
Design/Methodology/Approach - To analyze the reliability and validity of research variables such as ESG, sustainability, and customer attitude included in the conceptual research model of this study, EFA and CFA analyses were performed, and possible mediating effects in the relationship between ESG and customer attitude were verified. A structural equation model and Sobel test were performed to verify the research model and its possibilities.
Findings - As a result of surveying 300 consumers on ESG activities, the following research results were obtained. First, environment had the most significant positive effect on environmental sustainability, followed by social sustainability and economic sustainability, in that order. Second, while society had a significant positive effect on economic sustainability and social sustainability, it did not have a significant effect on environmental sustainability. Third, governance had the most significant positive effect on social sustainability, followed by economic sustainability and environmental sustainability, in that order. Fourth, economic sustainability had the most significant positive effect on customer value, followed by customer value in order of social sustainability and environmental sustainability.
Research Implications - This study found that sustainability acts as a mediating effect in the relationship between ESG activities and customer value. In particular, environmental sustainability, economic sustainability, and social sustainability played a mediating role in the relationship between environment, governance, and customer value. In contrast, economic sustainability and social sustainability played a mediating role in the relationship between society and customer attitudes, while environmental sustainability did not play a mediating role.
Tarihsel Anlatıda Kadının Side Turizmindeki Yeri: Bir Devrin Hikayesi
Authors: TOKER Arzu , KAYA Songül Çilem
Published: October 2023

Bu çalışma kapsamında Cumhuriyet Tarihi boyunca kadının Side turizmindeki yerini belirlemek amaçlanmaktadır. Turizmde kadın emeğinin durumunu anlamak bir araştırma gündemi olarak güncelliğini her zaman korumaktadır. Küresel turizmde işgücünün yarısından fazlasını kadınların karşıladığı düşünüldüğünde, kadın ve turizm ilişkisinin araştırılması önem taşımaktadır. Bu araştırmada da Türkiye turizminin en önemli bölgelerinden biri olan Side’de tarihsel süreçte kadının turizmdeki yeri anlaşılmaya çalışılmıştır. Bu amaçla 2012-2015 yılları arasında Anadolu Üniversitesi Turizm Fakültesi tarafından gerçekleştirilen Türkiye Turizmi Sözlü Tarih Projesi çerçevesinde Side’de yapılan görüşme metinlerinin deşifrelerinden oluşan dokümanlar incelenmiş ve katılımcı anlatıları kronolojik bir akışla sunulmuştur. Araştırmanın sonuçları, Side turizminin kabul sürecinin kendi tarihsel bağlamı içerisinde özgün nitelikler taşıdığını, turizmi kabul sürecinde kültürün etkili olduğunu, Side turizminin öncülüğünü kadınların yaptığını göstermiştir. Ayrıca turizmin kitleselleşmesinin, kadınların sektördeki konumlarını değiştirdiği de ulaşılan sonuçlar arasındadır.