bluuebunny/crossref_metadata_2025 huggingface dataset:
BIOCHEMICAL AND MICROBIOLOGICAL CHARACTERIZATION OF TRADITIONAL ROMANIAN FERMENTED DRINKS - SOCATA AND BORȘ - A REVIEW
Authors: CONSTANTIN Ecaterina Andreea , CONSTANTINESCU-ARUXANDEI Diana , MATEI Florentina , SHAPOSHNIKOV Sergey , OANCEA Florin
Published: July 2023

Fermented beverages are products that involve biochemical changes during the microaerophilic processes under the action of microorganisms and their secreted enzymes. Food fermentations include four main processes: lactic fermentation, alcoholic fermentation, acetic fermentation (which is an aerobic process) and alkaline fermentation. In this paper we aim to review the studies carried out on two Romanian traditional non-dairy fermented beverages which have not benefited of the attention they deserve, such as elderflower (Sambucus nigra) fermented drink (socata) and sour liquid soup seasoning (borș). These drinks are derived from a sweetened infusion of elder flowers (socata) and wheat bran (borș) that are fermented by consortia of microorganisms. Socata was shown to be fermented by consortia of yeast and lactic acid bacteria (LAB). Borș is produced by fermentation with heterofermentative LAB. These traditional fermented beverages are characterized as a source of probiotics. Previous research has demonstrated that both are a rich source of bioactive/antioxidant flavonoids and phenolic acids, minerals and vitamins. Several techniques are used for the determination of the bioactive compounds and antioxidant activity, such as the determination of individual phenolic compounds using HPLC, determination of total phenolic content using Folin- Ciocalteu reagent, determination of ABTS and DPPH radical cation scavenging activity, determination of ferric reducing antioxidant power (FRAP) assay.
Current Situation of Adipose-Derived Stem Cells Treatments for Knee Ostheoarthritis and Hypothesis for a New Protocol Based on Cryoconservation and Multiple Injections of Mechanically Fragmented Adipose Tissue Extracts
Authors: Rucci M. , Onorato F. , Formica M. , Ferracini R.
Published: July 2023

Osteoarthritis (OA) is a widespread degenerative joint disease. The knee arthroplasty has represented for about 40 years the main treatment option, when pain and functional decrease became unbearable for the patient. The knee arthroplasty represents a challenging surgical operation, in which, based on current data available, about 20% of the patients are left totally or partially unsatisfied with the clinical result. A recent therapeutic alternative for mild-to-moderate grade OA (Kellgren-Lawrence grade II to III) in order to delay (or ultimately avoid) the need for prosthetic surgery, is a treatment with Adipose-Derived Stem Cells (or ADSCs). The safety and efficacy in terms of functional improvement, cartilage repair and inflammation reduction were already reported for OA treatment through a single intra-articular injection of Micro-Fragmented Autologous Fat Tissue (M-FAT), which is known to be rich in ADSCs. This efficacy period appears to be ranging from several months to a few years. Research has shown that the effect of single-dose M-FAT treatment, despite being evident in most cases, is not statistically uniform among the studies now available. This is also due to different treatment protocols, that leave to every research group the ultimate choice of preparation methods, rules and exclusion criteria. It is possible, because of this, to hypothesize a new kind of treatment protocol based on a single surgical harvesting operation. The extract would then need to be cryopreserved and administered multiple times over a several-years period. We hope, thanks to the subsequent injections of purified extract, to prolong and boost the effect of the treatment. We tried to elaborate, based on our experience in the field, a new protocol for this multi-injection treatment. This protocol is going to be applied to a small number of patients and evaluated over time, to elaborate the actual benefit from a treatment like this.
Evaluation of Pulmonary Functions by Spirometry after Stereotactic Body Radiotherapy in Lung Tumors
Authors: Marin Alexandra , Cahuayme Abraham , Albiac Mónica , Vizcay Enar , Cristau Josep , Pijoan Xavier , Sagredo Jordi
Published: July 2023

Introduction: To evaluate changes in pulmonary function by spirometry after stereotactic body radiotherapy (SBRT). Methods: A single-center, retrospective study was performed which analyzed lung function after SBRT from January 1, 2015 to January 31, 2020. Eligible patients were ≥18 years of age, with early-stage lung cancer or lung metastases ≤5 cm and Karnofsky performance status (KPS) >70. Patients were excluded if they had a history of non-infectious pneumonitis or interstitial lung disease. Clinical cases were discussed in a multidisciplinary tumor board, and the patients were classified as surgically resectable but medically inoperable. Mixed-effects models were used to evaluate changes in forced expiratory volume in 1 (FEV1), forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO) at 3, 6, 12, and 24 months after SBRT. Results: Fifty-two patients underwent SBRT. Median follow-up spirometry post-SBRT was 12 months (range, 12-24). No significant differences were observed during the first year in both liters and the percentage of predicted FEV1 evolution. A gain of 5.9% [95% CI, 2.3; 9.6 percent (p=0.0014)] was beheld after 24 months post-SBRT. Although, no significant difference has been viewed when we analyze it in liters with an FEV1 value 24 months post-SBRT of 1.57 liters [95% CI, 1.56; 1.59 liters (p=0.848)]. There are no differences when we analyze FVC evolution according to liters during the first two years post treatment. Finally, no differences were observed when analyzing DLCO evolution according to percentage or as ml/min/kPa. Conclusions: SBRT in primary lung tumors or pulmonary metastases does not negatively influence pulmonary function assessed by spirometry at least in the first two years after treatment.
GENETIC PREDISPOSITION TO CANCER: REPORT OF THE FIRST CASE IN PERU OF THE 657DEL5 VARIANT IN THE NBN GENE
Authors: Meza-Garcia Karoll , Castro-Mujica Maria , Marlar Riley , Ziegler-Rodriguez Gonzalo
Published: July 2023

Background: Breast cancer has well known genetic mutations affecting the DNA-damage repair mechanism and predispose for the development of the disease. The heterozygous pathogenic variants found in the NBN gene has been linked to a higher likelihood of developing cancer; Methods: clinical description of 3 cases and review of the literature; Results: We describe a family cluster of 3 sisters affected by different cancer types. One of them had a breast cancer associated to the 657del5 pathogenic variant in the NBN gene and was handled with breast conserving therapy. Another had bilateral breast cancer and the third one had endometrial cancer; Conclusions: Breast cancer associated with the 657del5 pathogenic variant in the NBN gene has been described in various publications, mainly in populations other than Peru.
Health Literacy in Children and Adolescents: A Review of the State of the Art
Authors: Rubio Maria , Blay Carles
Published: July 2023

Health literacy has been defined as the ability of people to access quality health information and apply it, making appropriate decisions in the process of health and a correct use of health services. Despite the large body of literature produced since the first studies of this topic on the adult population, there is less scientific documentation regarding children and adolescents. The research team conducted a literature review of health literacy in children and adolescents; as well as the role of digital health literacy and other divides in the health status of this specific group of the population. The results of the literature review showed that health literacy is crucial to obtain a good physical, emotional and cognitive development. It is also related with the acquisition of healthy behaviors and lifestyles. The level of health literacy depends on many factors such as personal health status, the existence of health problems or diseases; as well as socio-economic status, cultural, social, and demographic determinants of health, among other variables. These aspects at the family level, friends, and school life, moreover, influence children and adolescents. In this group of the population, health status and healthy lifestyles are not only influenced by the level of individual (or parental) health literacy, but also by the social context in which the child or youth is immersed. In addition, these variables related to socio-economic and cultural factors are associated with the existence of gaps or divides in certain groups. In this scenario, an adequate conceptualization of health literacy during childhood and adolescence is necessary when designing appropriate interventions and policies for this group of the population. In order to achieve this, it is necessary to define what we mean by health literacy and how we are going to measure it. In summary, it is important not to focus only on an individual perspective; on the contrary, it is necessary to understand health literacy in the context where children and youth live and develop, as well as their interactions with the health, educational and social system. Further research is needed to explore more in depth the importance of health literacy in children and adolescence.
Predictive Modeling of Metabolomics data for the Identification of Biomarkers in Chronic Kidney Disease
Authors: Sheetal Ambulge , Reddy Ambati , Arora Pooja , Puri Veena , Bharatam Prasad
Published: July 2023

Chronic kidney disease is a specific type of Kidney Disease in which, a gradual loss of Kidney Function over a period of 3-30 months is noticeable. Early detection is imperative to prevent this catastrophic event and initiate treatment that may mitigate renal injury. Metabolomics data in Chronic Kidney Disease carries a lot of information about biomarkers. However, it is not clear which of these biomarkers are significant, biostatistical analysis of metabolomics data might provide the clues. In this work, an attempt has been made to find novel biomarkers that may be responsible for causing Chronic Kidney Disease by employing bioinformatics and advanced computational tools. The Chronic Kidney Disease data of the patients (in stages 3 and 4) was selected and data was segregated based on renal and cardiovascular parameters. The study consisted 441 patients and 293 metabolites. Subsequently the identification of top metabolites (as biomarkers) was carried out using statistical methods like t-test, Principal component analysis and partial least square analysis. Nine biomarkers were identified from these statistical analyses i.e Galacturonic acid, p-cresol, L-serine, L-glutamine, Lactose, 2-O-Glycerol-.alpha.-d-galactopyranoside, hexa-TMS, Butanoic acid, 2,4-bis[(trimethylsilyl)oxy]-, trimethylsilyl ester, Pseudo uridine penta-tms and Myo-inositol. The Reactivity of identified metabolites was confirmed by using quantum chemistry calculations in Gaussian software. Heat Map was constructed to find out the variations in concentrations of biomarkers in healthy and CKD patients and the showed the higher concentrations of L-serine, Galacturonic acid , L-glutamine and lower concentrations of Pseudo uridine penta-tms, Butanoic acid, 2,4-bis[(trimethylsilyl)oxy]-, trimethylsilyl ester , 2-O-Glycerol-.alpha.-d-galactopyranoside, hexa-TMS , Myo-inositol , p-cresol , Lactose in Death Patients. The biological significance of identified top metabolites has been evaluated by identifying the metabolic pathways in which the metabolites are involved. The metabolites which were found to be toxic are pseudouridine, L-glutamine, and galactouronic acid as per the previous reported literature. The Variations in concentration of these metabolites are responsible for the Death of patient with Chronic Kidney Disease.
Current Evidence for the Involvement of Hypogonadism and Modulation of Steroid Receptors in Prostate Carcinoma
Authors: Popoola Olayiwola , Samuel Titilola , Popoola Mayowa , Akinsola Simisola , Magbagbeola Olubunmi , Akinloye Oluyemi
Published: July 2023

Prostate cancer (PCa) is the most prevalent cancer in the Nigerian male population, similar to other black populations. It is postulated that exposure to endogenous or environmental steroids prompts prostatic mediated changes via steroid receptors as well as a decrease in the androgen/estrogen ratio and aging. Thereby contributing to prostatic carcinogenesis and disease progression. This study is aimed to determine the plasma levels of testosterone, 17β-estradiol as well as the pattern of expression of steroid receptors in subjects with prostate cancer, benign prostatic hyperplasia, and controls. Study participants are made up of a total of 195 consented volunteers consisting of 65 Prostate cancer (PCa) and 65 benign prostatic hyperplasia (BPH) treatment naïve participants and 65 apparently healthy subjects as controls. Anthropometric data were measured using standard methods and biochemical parameters determined by enzyme-linked immunosorbent assay (ELISA). The gene expression is quantified by Real-Time PCR with PerfeCTa SYBR Green SuperMix on CFX96 Bio-Rad, USA. The results of this study showed increased levels of 17β-estradiol, total androgen receptor (AR) and estrogen receptor-beta (Erβ) in prostate cancer participants compared with controls (P<0.05). A Significant reduction in plasma levels of testosterone in prostate cancer subjects compared with BPH and controls was observed (P<0.001). The plasma levels of androgen receptors were significantly increased in PCa and BPH participants (p<0.05). We observed a positive correlation between ERβ levels and PSA levels in the PCa group (r=0.32, p=0.02). There was a differential expression of AR, ESR1 and ESR2 in the studied group. This study shows hypogonadism and an increased 17β-estradiol, ERβ, and AR levels in subjects with prostate cancer. This data suggests that modulation of these hormones and their receptors may be associated with initiation and progression of prostate cancer and could be valuable in the interpretation of PSA kinetics and stratification of cases after screening.
Methods of Postural Assessment used in Hyperkyphotic Elders: A Narrative Review
Authors: Kumar Sunil , Singla Deepika , Chhugani Manju
Published: July 2023

Background and objective: Aging is a natural process and associated changes in posture, mainly at the spine lead to complications in functional independence and quality of life. The aim of this review is to identify existing measuring tools used to measure hyperkyphotic posture in the elderly population. Methods: Electronic databases were searched from January 2001 to December 2021, with different combinations of keywords, “thoracic kyphosis” or “hyperkyphosis” or “kyphotic posture” or hyperkyphotic posture” or “flexed posture” or “spinal curve” and “assessment”, “measurement” or “instrument” or “equipment” and “elderly” or “older adults” or “elders”. Studies were selected based on inclusion and exclusion criteria. Results: Four thousand one hundred sixty-six studies were obtained from electronic databases. After the removal of 3227 duplicate studies, twenty-six relevant studies were selected from 939 unique studies. Radiographic measurement, Flexicurve ruler, Debrunner kyphometer, Gravity-dependent inclinometer, occiput to wall distance (OTW), tragus to wall distance (TWD), and spinal mouse were used for hyperkyphotic measurement. The radiographic method and Flexicurve showed very high reliability. The block method and flexicurve are widely used methods for assessing hyperkyphotic posture in older adults. Conclusion: Postural assessment methods showed variability in defining criteria for hyperkyphosis in the elderly population. Flexicurve and block methods can be used as non-invasive methods for the early detection of hyperkyphosis. In the future, more measurement tools should be developed for the measurement of kyphosis, that are cost-effective, with excellent reliability and validity.
Virtual Acceptance and Commitment Therapy (vACT) For Youth with Chronic Illnesses: A Case Report
Authors: N. E. Mahrer , V. S. Sommer , D. I. Berman , N Ngo , J. I. Gold
Published: July 2023

Youth with chronic medical conditions need accessible and effective mental health interventions to address high levels of disruption in their psychological, social, and emotional development. Acceptance and Commitment Therapy (ACT) is an empirically supported psychotherapy based on behavioral interventions that combines the principles of Relational Frame Theory and Mindfulness. ACT has been shown to be effective in populations of youth with various chronic conditions. As telehealth use has increased, ACT has been administered virtually on an individual level to adults and adolescents with chronic conditions, including chronic pain and Type II diabetes. However, few studies have incorporated a group-based element to the virtual delivery of ACT, which may be more accessible, cost-effective and may have additional therapeutic value in the form of peer connection and cohesion. To investigate the potential benefits of a virtual group model, we developed a web-based virtual ACT (vACT) group intervention for youth with chronic illness aged 14-21. The 6-week virtual group consisted of 1.5-hour sessions that each focused on a unique ACT concept: acceptance, values, mindfulness, cognitive defusion, experiential avoidance, and willingness/commitment. Additionally, the sessions included exercises to engage group members and teach skills. Baseline, post-, and follow-up data were collected on stress, mental health, functional outcomes, and satisfaction from one participant, “Kasey”, a 14-year-old Latina adolescent with comorbid Type I diabetes, depression, and anxiety. This case report details the procedures for the vACT group, discusses the barriers, and provides examples and recommendations for future administration of the group model. The report also describes Kasey’s experience during the group and presents quantitative/qualitative data supporting her improvement. Kasey’s perceived stress declined across sessions, while her anxiety sensitivity and depressive symptoms improved from the moderate range to the mild range, with sustained improvements at follow-up. Additionally, Kasey reported improvements in her peer relations with sustained improvements at follow-up, which was initially a significant concern. This case report provides promising preliminary data for the virtual administration of a group-based ACT intervention. We hope that clinicians can use this approach to provide evidence-based services that can reach a wider range of youth with chronic illnesses who may not otherwise have access to care and/or are estranged from their peers.
Late-stage Attentional Bias towards Food Cues Varies According to Weight Status
Authors: Wheeler Nicholas , Colella Jordan , Anderson III Robert , McFee Kylie , Flack Kyle
Published: July 2023

The Current food environment has become increasingly obesogenic, with rates of obesity and related conditions continually rising. Advertisements for energy-dense foods are abundant and promote unhealthy eating behaviors by capitalizing on one’s attentional bias towards food cues, a cognitive process resulting from the sensitization of highly reinforcing food. A heightened awareness towards food cues may promote overconsumption of energy-dense foods. The current study employed novel eye-tracking methodology to capture sustained, or late-stage, attentional bias towards food cues. Late-stage attentional bias is the aspect of attentional bias under conscious control and likely more prone to modification compared to initial/ early-stage attentional bias, which reflects automatic processes. The present study hypothesized late-stage attentional bias towards food cues is greater among individuals classified as overweight/obese than those classified as normal weight. Thirty (30) participants classified as overweight/obese (BMI >25) and 47 classified as normal weight (BMI <25) were assessed for late-stage attentional bias towards food cues, conceptualized as the percentage of time fixated on food cues when both food and neutral images were presented during a food-specific visual probe procedure task. Percentage of time fixated on food cues was 51.25 ± 1.27 (mean + SE) among individuals classified as overweight to obese while those classified as normal weight had a percent fixation of 47.26 ± 0.87 (P=0.03). In conclusion, individuals classified as overweight to obese have greater late-stage attentional bias towards food cues. This establishes an important factor influencing energy intake that may be modified in future clinical trials.
Newer Perspectives in Anesthesiology: A Philatelic Based Review
Authors: Krishnamurti Chandrasekhar , Mehdi Zohra , Chandrasekhar Vijayalakshmi
Published: July 2023

Over the past decade, the practice of anesthesiology had become inextricably dependent upon technology. Anesthetics were first discovered, then made increasingly safe, and now, more precise and efficient, all due to tremendous advances in monitoring and delivery technology. Telemedicine has revolutionized medicine and preoperative evaluations and teaching are being done via teleconference and zoom meetings. Patient monitoring has become noninvasive, and closed-loop anesthesia delivery systems are making anesthetic administration very precise and safe. Next-generation technology and innovations will eliminate human errors entirely.
UCP2 Upregulation Increases Fra-1 Expression and S-phase Cell Population without Decreasing Apoptosis during Skin Cell Transformation
Authors: Zhao Yunfeng , Sreedhar Annapoorna , Zhang Chunjing , Jacquet Noel
Published: July 2023

Upregulation of uncoupling protein 2 (UCP2) is considered a prosurvival mechanism for cancer cells. This prosurvival function is thought to be mediated by UCP2’s uncoupling activity which reduces the production of superoxide in the mitochondria. However, exactly how highly expressed UCP2 regulates cell proliferation, cell cycle, and cell death during the early stage of tumorigenesis has not been studied thoroughly. For this purpose, we generated UCP2 stably overexpressed JB6 Cl-41 cells (a skin cell transformation model) and performed studies to answer the above questions. Our results demonstrated that UCP2 overexpression enhanced cell proliferation, activation of the oncoprotein Fra-1, anchorage-independent growth, 3D spheroids growth, and glucose uptake during skin cell transformation. Next, our results demonstrated that UCP2 overexpression resulted in marked decreases in the proportion of the cells in the G1 phase and an increase of cells in the S phase of the cell cycle, which was accompanied by increased expression of Cyclin E and Cdk2. Lastly, UCP2 overexpression did not enhance or suppress apoptosis during skin cell transformation, as indicated by Annexin V and active caspase 3/7 staining. Taken together, these data suggest that UCP2 upregulation mainly enhances the Fra-1 oncogenic pathway which drives cell proliferation, without inhibiting apoptosis during skin cell transformation.
Advancements and Challenges in Breast Cancer: A Comprehensive Review
Authors: Sonalika Soumya , Mishra Sushree , Mahapatro Subhashree , Sahoo Devasmita
Published: July 2023

Introduction: Breast cancer is a global health concern, accounting for significant morbidity and mortality among women. The fragile ill prepared healthcare systems in low- & middle-income countries need to address these challenges find solutions with their limited resources. Objectives: Through a critical examination of the literature, this article aims to contribute to a better understanding of breast cancer and to stimulate further research in this field. Methods & Analysis: This review article provides an in-depth analysis of the current state of breast cancer research, focusing on advancements in diagnosis, treatment, and prevention, as well as the challenges and future directions. Conclusion: Emerging technologies, such as AI, 3D bioprinting, and nanotechnology, hold promise for addressing the challenges like management of metastatic disease, global disparities in outcomes, and the need for a better understanding of breast cancer etiology and revolutionizing breast cancer care.
The influence of visible light within the solar spectrum: How damaging is it to human skin and is it accounted for in sun protection measures?
Authors: Smith David
Published: July 2023

Public health messages clearly state the risks of solar radiation and how the risk can be mitigated. This is supported by the availability of creams that effectively block out the ultraviolet component of solar radiation. Why then does the incidence of skin cancer and particularly melanoma remain so disturbingly high in Caucasian populations? Almost all organisms on the planet have had to adapt to the presence of solar radiation since the beginning of evolutionary time. There are beneficial effects as well as risks in exposure, not the least of which is that it is the ultimate energy source for living species. We need to re-examine attitudes and exposure patterns with an appreciation that some exposure is essential for good health. A balance needs to be found between benefits and risks. This can only be done by understanding that there are a range of wavelengths of light with different effects rather than a focus solely on the adverse effects of the ultraviolet component.
A Review of Factors Influencing Anxiety and Depression in Persons with Multiple Sclerosis during the COVID-19 Pandemic
Authors: McLaughlin Patricia , Odom Laura , Zagon Ian
Published: July 2023

Patients with multiple sclerosis have been subjected to extra levels of stress during the COVID-19 pandemic when they were singled out by governmental regulatory agencies as sufficiently immune-compromised persons that should be in the first group to receive the untested, new COVID-19 vaccine. The designation of these persons in such a high-risk group compounded their anxiety and depression. Early in the disease in 2020-2021, little was known about the disease, the vaccine, or whether their disease-modifying therapies for multiple sclerosis were subjecting them to more immunomodulatory suppression. This review is not comprehensive of all articles written on COVID-19 and multiple sclerosis, but selectively looks at research on COVID-19 and use of low-doses of naltrexone as treatment. Specific causes for anxiety and depression are discussed in light of evidence that suggests that the length of disease, rather than age, sex, or therapy leads to more anxiety. Low-dose naltrexone in combination with other disease-modifying therapies, or alone, reduced the perceived levels of anxiety. These data suggest that clinicians may want to prescribe low-dose naltrexone for early-stage multiple sclerosis patients.
Various applications of chlorhexidine as an antimicrobial agent in dentistry: A review
Authors: Verma Tanisha , Grover Naman , Malhotra Saiyam
Published: July 2023

Chlorhexidine is a broad spectrum antimicrobial agent, which has been into used in the dental practice as a major anti plaque agent. Chlorhexidine not only shows the property of substantivity, but due to its broad spectrum of antimicrobial property, it is used in various oral diseases. Different uses of chlorhexidine are, prime most is as a major antiplaque agent, it can be used as a root canal irrigant during the process of root canal treatment, it can be used in the prevention of the dental caries as it results in the suppression of the streptococcus mutans in the oral cavity. It helps in the prevention of the secondary infection from the apthous ulcers as well as from the alveolar osteitis, it can also be prescribed to the patient suffering from denture stomatitis, show promising results also as an anti fungal agent. The use of chlorhexidine mouth wash is not recommended for long term use, as it results in discoloration, so to over come this disadvantage of the chlorhexidine a new formulation with properties of anti discoloration is preferred in case for long term use of the chlorhexidine, and this new system with property of anti discoloration shows promising results in every manner.
Artificial intelligence in forensic odontology – A review
Authors: Ahmed Osama , Saleem Saleh Abdul , Khan Aquib Ali , Daruwala Sana , Pettiwala Anam
Published: July 2023

Revolutionary advancements in dentistry have been brought about by robotic advancements that mimic the functions of the human brain. Over an extended period, both dental and medical documentation has undergone computerization, with cloud servers serving as reliable backups. These records have played a crucial role in identifying victims of major catastrophes such as the World Trade Centre disaster and the Indian Ocean tsunami. Often, in these cases, the bodies are severely damaged and unidentifiable, except for the remaining teeth and the resilient jawbone, which exhibit remarkable resistance to harsh conditions. These elements have proven to be vital in the process of identifying disaster victims. To conduct the present review, extensive online research was performed using databases such as Google Scholar, PubMed, Medline, and IEEE Xplore, up until December 2022.
Isolated gingival overgrowths: Case report
Authors: Sharma Ankita , Chauhan Shailandra , Sinha Aditya , Sharma Satendra
Published: July 2023

It is considered that the pyogenic granuloma is a frantic tissue reaction to local irritation or damage. These lesions usually appear as a single nodule or sessile papule with a smooth or lobulated surface. These are available in a range of sizes ranging from a few millimetres to many centimetres. Pyogenic granuloma of the oral cavity is said to affect the gingiva 75% of the time. It may appear extraterrestrially on occasion. We present a case of Pyogenic granuloma in a 22-year-old man's lower jaw, which is a common location for this lesion.
From scalpels to algorithms: The next step in surgical advancement
Authors: Shetti Akshaya Narayan , Ashokan Bhaskaran , Hivre Mangesh , Jayanthi D.  , Mustilwar Rachita G , Kant Krishan
Published: July 2023

The field of surgery has come a long way since the days of sharpened stones and crude instruments. Today, medical professionals rely on a range of high-tech tools and technologies to perform a wide variety of procedures, from routine operations to life-saving treatments. As surgical technology continues to advance, many experts believe that algorithms will play an increasingly important role in the operating room of the future. Algorithms, which are sets of mathematical instructions that help computers solve complex problems, can be used in a number of ways to enhance the surgical process. For example, they can be used to create virtual simulations of surgical procedures, allowing medical professionals to practice and perfect their techniques in a safe and controlled environment. Algorithms can also be used to analyze patient data, providing doctors with valuable insights into the best ways to approach a particular case. Another area where algorithms are expected to make a big impact is in the field of robotics. Robotic systems can be programmed to perform complex surgical procedures with greater precision and accuracy than is possible with human hands alone. In addition, robots can be equipped with algorithms that help them make real-time decisions during a procedure, ensuring that the patient receives the best possible care. Overall, the integration of algorithms into the surgical process represents a major step forward in the field of medicine.
The intersection of pharmacology and dentistry: A comprehensive overview of pharmacotherapeutics
Authors: Shetti Akshaya Narayan , Shenoy Shailesh , Pasha Zameer , Rajendiran Suresh , Ahmed Syed Owais , Kant Krishan
Published: July 2023

Pharmacotherapy is an essential component of dental practice to manage pain, prevent infections, and maintain oral health. Analgesics such as non steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly used to manage pain during and after dental procedures. Antibiotics are prescribed to treat and prevent infections, but their use should be limited to reduce the risk of antibiotic resistance. Local anesthetics provide safe and effective pain relief during dental procedures. Fluorides are used to prevent tooth decay and strengthen tooth enamel. Dental healthcare providers should evaluate each patient's individual needs and medical history to determine the most appropriate pharmacotherapy. Patient education on the proper use of medications and potential side effects is also important. By incorporating pharmacotherapy as part of a comprehensive dental care plan, patients can experience a more comfortable and successful dental experience.
Dietary phytochemicals and cancer chemoprevention
Authors: Sheikh Abid Ali , Arora Amar , Chauhan Neha
Published: July 2023

The goal of cancer chemotherapy is to prevent or slow the growth of tumors by using various Biological or natural agents. Epidemiological and pre-clinical data indicate that phytochemicals can influence cell proliferation and cell cycle regulation, are typically involved in multiple signaling pathways that are frequently disrupted during tumour initiation, proliferation, and propagation, strengthen the host immune system, and make cancer cells more susceptible to cell-damaging agents. Only a small subset of these medicines have undergone clinical testing, and the results of those trials have been inconsistent, despite favorable outcomes from Experimental investigation. Recognizing the impact of these dietary changes may inspire easy and affordable solutions to improve health globally as the global rate of cancer continues to rise. In this article, we provide a summary of the information on a few phytochemicals with a particular focus on the clinical data demonstrating these compounds' effectiveness in populations at significant risk.
Analytical method development and validation of UV-visible spectrophotometric method for the estimation of CNS stimulant drug in bulk
Authors: Khan Saba , Shaikh Mohd Anas , Shaikh Nehal , Agnihotri Jaya
Published: July 2023

A simple, rapid, accurate, economical and precise UV/VIS method has been developed and validated. Choices of a common solvent were essential so various solvent ranges including methanol, ethanol, acetonitrile, and 0.1 N HCL, and various concentrations ranges of various buffers were analyzed. Hence 0.1 N HCL was selected as a solvent for the proposed method. Caffeine showed maximum absorbance at 273nm.Drug obey Beer Lambert’s law in the concentration range of 3-18 μg/mL for Caffeine. The LOD and LOQ were found to be 0.5476 μg/mL and 1.6594 μg/mL for Caffeine. The method was quantitatively evaluated in terms of linearity, precision, precision, LOD, LOQ and recovery. The method is simple, convenient and suitable for the analysis of Caffeine in bulk drugs.
Financial Development and Human Development in Nigeria
Authors: Afolabi Mutiu Adeniyi , Akanbi Bosede , Olayinka Onifade Emmanuel
Published: July 2023

This study examines the relationship between financial development indicators and human development in Nigeria from 1990-2019. It investigates the effect of broad money supply/Gross Domestic Product (GDP) on Human development; it examines the impact of credit supply/GDP on human development and assesses the link between market capitalization and human development. The study employs expo-facto research design and Autoregressive Distributed Lag to examine the relationship between Financial Development and Human Development. Previous studies in Nigeria had focused on financial development and economic growth, financial deepening and economic growth. Therefore, this study is a response to the dearth of relevant empirical studies on financial development and human development in Nigeria. From the results, the long run net effect of broad money supply/GDP on human development is negligible and positive. M2/GDP in Nigeria only account for the extent of monetization rather than financial intermediation. The long run net effect of credit supply/GDP on human development is negligible and positive. The long-run effect of M2/GDP, CPS/GDP are statistically significant but has no power to substantially influence human development in Nigeria. The study suggests that banks should effectively perform their intermediation roles and effort should be made by the policy makers to widen/broaden the Nigeria capital market activity. Policy makers should concentrate on financial system and their roles for effective money supply and credit supply while implementing economic policies.
Isolasi dan Uji Aktivitas Selulolitik Bakteri Asal Limbah Bagas
Authors: Dewi Chusniasih  , Erma Suryanti  , Erina Safitri
Published: July 2023

Bagasse is one of the by-products of granulated sugar industries or processed beverages that become waste in the environment. The bagasse will be overgrown by cellulolytic bacteria that produce cellulase enzymes. This study aims to isolate, characterize, and measure bacterial cellulase activity qualitatively and quantitatively. The research phase included isolation and characterization of bacteria, qualitative cellulase activity test, preparing standard curves and bacterial growth curves, crude extract cellulase production, constructing standard glucose curves, quantitative enzyme activity tests, and data analysis. Six isolates with macroscopic characteristics varied in color, elevation, margins, and colony shape; three bacillus isolates, one short bacillus isolate, and two cocci isolates were obtained. All isolates showed positive test results of amylum, triple sugar iron agar, and catalase; five citrate-positive isolates, and three motile-positive isolates. From the cellulase qualitative test, two bacterial isolates had the highest cellulolytic index, namely AT1 (1.79) and BAW3 (1.72) on 0.5% CMC media. The quantitative cellulase test results of the two selected isolates were 0.01176 U/mL for AT1 and 0.01170 U/mL for BAW3, both of which are still classified as low degradation capabilities.

 

Keywords: cellulase activity, cellulolytic index, Sugarcane waste
Respons Fisiologis Sapi Pedaging terhadap Pengabutan Air Menggunakan Sprinkler Water
Authors: Santoso Koekoeh , Tarigan Aldo Febriano , Komariah
Published: July 2023

Indonesia is facing the problem of low productivity of cattle. To increase the productivity of cattle producer, it can actually be done by relocating the cattle to the comfort zone by observing the physiological response. The purpose of this research is to evaluate the effects of misting cattle’s environment by using water sprinkler on the physiological response and the microclimate of the cattle’s shed. The design used was a paired T-test for physiological and microclimate response variables with 5 replications and a completely randomized design to determine the difference between body surface temperatures. The observations were conducted before water misting and after water misting. The results showed that treatment of misting water in the afternoon significantly decreased (P<0.05) the variables of cage temperature, humidity, temperature humidity index, rectal temperature, respiratory rate, and heart rate. Water misting in the afternoon in cattle produced a good effect on all physiological response variables.
 
Keywords: beef cattle, pen microclimate, physiological responses, water sprinkler
Structural Equation Model - Parsial Least Square Faktor-Faktor yang Memengaruhi Penjualan Coffee Shop Bacarito Kopi di Kota Padang
Authors: Sumardi Vilda Ayuni , Syarfi Ira Wahyuni , Analia Devi
Published: July 2023

This study aims to analyze the factors that affect sales of coffee shop Bacarito Kopi in Padang City. The research method used is a survey method. Consumers who are used as respondents are determined by accidental sampling with a total of 70 respondents. The data were obtained through interview guides and distributing questionnaires using a likert scale. The data analysis used is descriptive qualitative and quantitative analysis. Based on the research results, it is known that in carrying out sales activities, Bacarito Kopi has paid attention to controlled environmental factors, namely aspects of the marketing mix, consisting of price, promotion, place or distribution, and product quality. Other efforts made by Bacarito Kopi in conducting sales activities are improving the company’s performance by providing optimal service to the consumers, innovating to survive during intense competition, and expanding the market by opening business branches, and utilizing distribution intermediaries to expand the market. Based on the tests conducted on the research variables using the SEM-PLS analysis method with smartPLS software, it shows that the factors that have a significant effect on the sales of coffee shop Bacarito Kopi in Padang City are the seller’s ability (X1), competition (X2), product quality (X3), price (X4), and promotion (X5).

 

Keywords: sales, marketing mix, coffee, bacarito kopi
Inventarisasi Jenis Tumbuhan Paku di Hutan Watumbolo, Kabupaten Sumba Barat Daya
Authors: Rafael Andriani , Daud Yanti , Hungu Octaviani
Published: July 2023

Indonesia is a tropical country that has high plant biodiversity. One of the plant groups that are rich in species are ferns. Ferns still exist until now and estimated at 10.000 species, which 3.000 species are grown out in Indonesia. Watumbolo forest is located in South West Sumba, with the average temperature ranges from 21-34°C, therefore the varians types of plants grow well in this forest, including ferns. The aim of this study was to identify the types of ferns found in the Watumbolo forest. Observations were also made on environmental conditions which included: air temperature, light intensity, soil moisture, and soil pH. This research was conducted using descriptive exploration method. The results obtained 18 species of ferns, namely: Asplenium nidus, Gleichenia linearis, Blechnum orientale, Davallia denticulata, Nephrolepis biserrata, Drynaria quercifolia, Drymoglossum piloselloides, Drynaria parishii, Nephrolepis hirsutula, Angiopteris evecta, Cyclosorus interruptus, Christella subpubescens, Lygodium microphyllum, Lygodium palmatum, Schizaea digitata, Selaginella plana, Lycopodium cernuum, and Psilotum nudum. Therefore, the results of temperature measurements in Watumbolo forest were between 22-28°C, air humidity 56-70%, light intensity 1069lux-6116lux, soil pH 7, and soil moisture 70-72%.

 

Keywords: ferns, South West Sumba, Watumbolo Forest
Peranan Teknologi Proses Pengolahan Pangan dalam Penurunan Alergenisitas Kerang-kerangan: Meta-analisis
Authors: Alia Andi Nadya Tita , Palupi Nurheni Sri , Giriwono Puspo Edi
Published: July 2023

Shellfish is widely consumed globally, one of the main reasons is because it contains good nutrition for health. The increased consumption also leads to adverse health problems such as food allergy. Food allergy is hypersensitivity reaction of the immune system caused by consumption or exposure to food. Various food processing methods has been proven to alter shellfish allergenicity with different effectiveness. This study aims to determine the most effective processing method to reduce shellfish allergenicity through meta-analysis. In total of 19 articles were obtained using PRISMA diagram, with publication year range 2006-2020. Data were analyzed to determine Standardized Mean Difference (SMD) with 95% confidence interval. Moist heating, high hydrostatic pressure, irradiation, and ultrasound processing have significant effect (p < 0,05) in reducing shellfish allergenicity. Meanwhile, boiling and roasting processing did not have a significant effect. Based on the results of the meta-analysis, high hydrostatic pressure is the most effective method in reducing shellfish allergenicity because it has the highest effect size value with -7,25 (95% CI: -9,11 s.d. -5,4; p < 0,00001).

 

Keywords: allergenicity, food processing, meta-analysis, shellfish
Determinan Terpilih untuk Kualitas Air Embung pada Lahan Tadah Hujan di Karanganyar, Jawa Tengah
Authors: Achmad Adi Surya Sustama  , Komariah Komariah , Lukito Arwa Farida , Sumani Sumani , Dwi Priyo Ariyanto  , Widyatmani Sih Dewi
Published: July 2023

Water conservation is needed to overcome the shortage of irrigation water through harvesting rainwater on rainfed land using small farm reservoir. Intensive agricultural activities cause a reduction in land resources which disrupts hydrological functions (water quantity and quality). This study aims to determine the selected parameters for small farm reservoir water quality and identify water quality based on irrigation water standards according to FAO (1994) and PP No. 82 of 2001. The research was conducted from March to December 2014 in Karanganyar Regency, Central Java Province. This study used a descriptive exploratory survey method with purposive sampling. Water quality data was analyzed using Principal Components Analysis (Multivariate Test) MINITAB 16 to determine the main components as the selected determinants. Furthermore, based on the results of the PCA analysis, 5 variables were obtained whose eigenvalue proportions met the main criteria, including DHL of 0.467; SAR of 0.542; pH of 0.538; Actual Savings Ratio (ASR) of 0.662; and water-air temperature deviation of 0.612. Furthermore, a match is made between the selected determinant measurement data and the water quality standard. The results of matching to the selected determinants for water quality in the reservoir have met the water quality standards for irrigation based on FAO (1994) and Government Regulation no. 82 (2001). The soil characteristics of the catchment area also affect water quality because in rainwater harvesting, surface runoff in the catchment area will flow and be accommodated by the small farm reservoir.

 

Keywords: water quality, small farm reservoir, PCA, water conservation, rainfall harvesting
The effect of docking defects on a metal-dielectric shielded waveguide in the EHF frequency range
Authors: Krutskikh Vladislav V. , Ushkov Andrey N. , Chernikov Anton I. , Zavitaev Denis O. , Mirzoyan Artavazd E.
Published: July 2023

Background. To improve the accuracy of navigation and radar systems, functional nodes of the EHF wavelength range are used. At the same time, an increase in the operating frequency increases the requirements for the accuracy of manufacturing and docking devices. Analysis of the propagation of electromagnetic waves, subject to the presence of defects in the waveguide paths, will allow determining sufficient manufacturing accuracy and evaluating physical processes in an irregular area. Aim. The aim of this work was to study the effect of sharp irregularities on the characteristics of the digital twin of a broadband shielded dielectric waveguide operating in the frequency range from 90 to 100 GHz. Methods. Using a numerical experiment, two variants of irregularity were investigated. They are presented in the form of displacement of sections of shielded dielectric waveguides in the vertical and horizontal planes. Results. According to the values of the transfer characteristic of the waveguide path, the regularities of the attenuation of the electromagnetic wave energy from the magnitude of the irregularity are revealed and the permissible manufacturing accuracy is proposed. Conclusion. To solve the problems of sewerage of weak signals, the authors recommend using a non-jointed manufacturing technology.