bluuebunny/crossref_metadata_2025 huggingface dataset:
Tracking of transplanted neural stem cells labeled with superparamagnetic iron oxide in ischemic stroke
Authors: Bai Ying , Zhou Zhongqiu , Zang Fengchao , Shen Ling , Zhang Yuan , Leng Shuo , Wang Guangtian , Han Bing
Published: December 2022

Clinical treatments for ischemic stroke are limited. At present, neural stem cell (NSC) therapy is considered a promising method for treating ischemic stroke. However, the behavior of transplanted NSCs remains ambiguous. Herein, we report the feasibility of superparamagnetic iron oxide labeling for long-time magnetic resonance imaging to track transplanted NSCs in a transient middle cerebral artery occlusion model. According to our studies, in vivo monitoring of transplanted NSCs during ischemic stroke in the current work may provide another insight into the tracking strategy of transplanted NSCs, thereby advancing NSC-based therapy toward clinical application.
Assignment of Rights Under a Simple Partnership Agreement: Search For the Optimal Model
Authors:   Alexeev Private Law Research Centre under the President of the Russian Federation, Goreva Anastasiya A.
Published: December 2022

The article discusses the main peculiarities of assignment of rights under a simple partnership agreement. Due to the lack of direct regulation of the assignment of rights under a simple partnership agreement, a position has been formed in judicial practice, according to which the assignment of rights is possible only with the consent of all the partners. The author criticizes this position and finds arguments against it in German law, the history of legal regulation a simple partnership agreement in Russia and the current legislation. The analysis allows us to find the optimal model of assignment of rights under a simple partnership agreement.
Microbial Based 'Cradle-to-Cradle' Approach to Attain Sustainable Development Goals of Food and Water Security, Good Health and Well Being without Crossing the Planetary Boundaries
Authors: Kaur Simrat , Diwan Fatema , Reddersen Brad
Published: December 2022

Our planet is facing a wide range of inevitable and unprecedented changes such as, the water and food scarcity to the natural calamities, namely flooding, droughts and rising sea levels. All these global challenges had been addressed through the Sustainable Development Goals (SDGs) drafted by the general assembly of the United Nations. In light of the current population growth, it is difficult to attain the sustainable development using conventional and non-renewable natural resources by remaining within the planetary boundaries of Earth. In order to maintain the environment and ecological integrity, the utilization of renewable living natural resources such as microbes become inevitable. Due to their roles in geo physio-chemical processes and bioenergy transformations, microbes allow 'cradle-to-cradle' model of development using wastewater as a renewable resource. The circular wastewater economy is the sole sustainable method to achieve the SDGs of providing clean water and the sanitation to address the issue of water insecurity. The review presents an inter-connected overview on the roles and functions performed by the prokaryotic (bacteria) and eukaryotic (algae and fungi) microorganisms, which are crucial for attaining the environment sustainability within the planetary boundaries. Apart from the environmental roles of microbes, the review also highlights the importance of human-microbe interactions (gut microbiome) and edible microbial species (algae and fungi) which are essential for developing sustainable future alternatives to human nutrition, well being and prevention of diseases.
THE EFFECT OF MOTIVATION, WORK DISCIPLINE AND WORK EXPERIENCE ON THE PERFORMANCE OF STAFF AT PRIMA INDONESIA UNIVERSITY
Authors: Faris Salman , Prasetya Syauqi Ari
Published: December 2022

This study aims to determine the effect of Motivation, Work Discipline and Work Experience to Work Performance of UNPRI's staff by partially or simultaneously. This research are conducted to UNPRI's staff. The population in this research are the staff of UNPRI. Data collection methods in this study were questionnaires. The sampling technique used is the Random Sampling technique. Determination of the number of samples in this research using the Slovin formula with an error level of 5% so as to obtain a sample of 148 staff from the total population of 234 staff at UNPRI. Analysis prerequisite test uses validity, reliability test. Data analysis techniques using descriptive analysis, multiple correlation analysis, multiple regression analysis and coefficient of determination with calculations using SPSS version 20.0. Research results sourced from data processing show a positive relationship between the variables of Motivation, Work Discipline and Work Experience to Work Performance of UNPRI's Staff. From the analysis it was found that partially the influence of Motivation, Work Discipline and Work Experience to Work Performance of UNPRI's Staff each amounted to 13,8%; 9,7% dan 15,4%. Simultaneously the effect of Motivation, Work Discipline and Work Experience on the performance of UNPRI's Staff was 38.90% and the rest was influenced by other variables not proposed in this study.
THE INFLUENCE OF MOTIVATION, SUPERVISION AND LEADER-MEMBER EXCHANGE (LMX) ON EMPLOYEE PERFORMANCE WITH TURNOVER INTENTION AS AN INTERVENING VARIABLE AT PT BANK MESTIKA DHARMA, TBK PEMATANG SIANTAR CITY
Authors: Nitalia Nitalia , Butarbutar Marisi , Efendi Efendi
Published: December 2022

Hasil peneltiian dapat disimpulkan sebagai berikut: 1. Motivasi sudah baik, pengawasan sudah baik, leader member exchange sudah baik, turnover intention sudah rendah dan kinerja karyawan sudah baik. 2. Motivasi, pengawasan, leader member exchange berpengaruh negatif dan signfikan terhadap turnover intention baik secara simultan maupun parsial kemudian turnover intention berpengaruh negatif dan signifikan terhadap kinerja karyawan. 3. Terdapat hubungan antara variabel bebas dimana terdapat hubungan yang rendah antara motivasi dengan pengawasan kemudian terdapat hubungan yang sedang antara pengawasan dengan leader member exchange dan terdapat hubungan yang sedang antara motivasi dengan leader member exchange. Terdapat hubungan antara variabel bebas dan terikat, terdapat hubungan yang kuat antara motivasi dengan turnover intention. Hubungan yang kuat antara pengawasan dengan turnover intention. Hubungan yang kuat antara leader member exchange dengan turnover. Hubungan yang sangat kuat antara motivasi, pengawasan, leader member exchange dengan turnover intention. Hubungan yang sangat kuat antara turnover intention dengan kinerja karyawan. 4. Hasil uji hipotesis H0 ditolak, artinya motivasi, pengawasan dan leader member exchange berpengaruh negatif signfikan terhadap turnover intention baik secara simultan maupun parsial. The research results can be summarized as follows: 1. Motivation is good, Supervision is good, leader-member exchange is good, the turnover intention is low and employee performance is good. 2. Motivation, Supervision, leader member exchange have a negative and significant effect on turnover intention both simultaneously and partially then turnover intention has a negative and significant effect on employee performance. 3. There is a relationship between the independent variables with a low relationship between motivation and Supervision, a moderate relationship between Supervision and leader-member exchange, and a moderate relationship between motivation and leader member exchange. There is a relationship between the independent and dependent variables, there is a strong relationship between motivation and turnover intention. There is a strong relationship between supervision and turnover intention. There is a strong relationship between leader member exchange and turnover. There is a strong relationship between motivation, Supervision, leader member exchange and turnover intention. There is a very strong relationship between turnover intention and employee performance. 4. The results of the H0 hypothesis test are rejected, meaning that motivation, Supervision and leader member exchange significantly negatively affect turnover intention simultaneously and partially.
Pollen morphology and flower visitors of Leiotulus aureus (Sm.) Pimenov & Ostr. (Apiaceae)
Authors: Mačukanović-Jocić Marina , Stešević Danijela , Rančić Dragana , Šundić Miloje
Published: December 2022

The pollen grains of Leiotulus aureus (syn. Malabaila aurea (Sm.) Boiss.) were examined by light and scanning electron microscopy in order to contribute to the taxonomical and melissopalynological studies of the species. Flower visitors have also been observed and analyzed aiming at clarifying some pollination aspects including the species contribution to the bee pasture. The pollen grains of L. aureus are isopolar, radially symmetrical, medium to large in size, tricolporate and perprolate. They are slightly equatorially constricted with obtuse polar caps and triangular in polar view. The sculpturing pattern is rugulate–microperforate. With regard to flower visitors, the following pollination types occurred: melittophily, myophily and sapromyophily and cantharophily. Some insects attracted by L. aureus cannot be considered pollinators but casual visitors. The flowers were the most frequently visited by honey bees during the midday.
Identifikasi Pulau-Pulau Di Provinsi DKI Jakarta Berdasarkan Gazeter Indonesia Unsur Rupabumi Wilayah Laut Tahun 2021
Authors: Yulius Yulius , Lesmana Salim Hadiwijaya , Ramdhan Muhammad
Published: December 2022

Identifikasi pulau-pulau dilakukan pada wilayah Kabupaten Kepulauan Seribu dan Kotamadya Jakarta Utara Provinsi DKI Jakarta. Jakarta adalah kota pesisir yang memiliki area berbentuk pulau di wilayah Utaranya. Pulau-pulau ini merupakan aset daerah yang harus dijaga keberadaannya. Pulau dapat berfungsi sebagai sumberdaya ekologis yang memberikan jasa lingkungan kepada wilayah sekitarnya. Pengambilan data pulau dilakukan dengan cara penelusuran data sekunder. Data pulau terdiri dari dua macam, yaitu pulau yang berpenduduk dan pulau yang tidak berpenduduk. Penelitian ini akan mencoba mengidentifikasi pulau-pulau yang terdaftar di dalam Gazeter Republik Indonesia Unsur Rupabumi Wilayah Laut tahun 2021. Tujuannya adalah memberikan informasi kepada khalayak umum tentang jumlah pulau terkini, kemudian memberikan rekomendasi kepada pihak terkait untuk melakukan upaya konservasi pulau-pulau tersebut. Hal ini penting dilakukan agar pulau-pulau tersebut tidak tenggelam. Identifikasi yang dilakukan berhasil mengindentifikasi 113 pulau yang terdaftar namanya dalam daftar pulau Gazeter Republik Indonesia Unsur Rupabumi Wilayah Laut tahun 2021 dengan 99 pulau tidak berpenduduk dan 14 pulau yang mempunyai penduduk.
Social-emotional Education in Local Heritage
Authors: Fuentes Moncada Leonel
Published: December 2022

Social-emotional learning is a tendency in education and must be accounted for in all areas of study. Heritage education cannot ignore this reality and must include and its planning and delivery effective strategies to implement and promote social-emotional competencies. The following work, proves patrimonial visits are an innovative approach towards coping with emotions in society. The activity proposed and studied in this investigation demonstrated the opportunities for integer learning during these experiences are real and cause a significant impact in students and society. This study demonstrated the most relevant aspects to consider in patrimonial visits.
Recursos de la locución radiofónica aplicables en la comunicación de divulgación en arqueología
Authors: San Martín González Francisco Javier
Published: December 2022

Los museos han perdido visitantes como consecuencia de la COVID-19 y la ciudadanía sigue creyendo que la ciencia es aburrida. En este contexto de crisis, examinamos, mediante técnicas de análisis de contenido, la presencia de la arqueología en programas de radio y estudiamos los recursos lingüísticos que hacen a la comunicación capaz de emocionar, aumentado las posibilidades de éxito de la divulgación científica. Concluimos que la escasez de equipo humano cualificado en comunicación de la ciencia y experto en recursos para hacerla más atractiva, puede poner en peligro la recuperación de los museos como centros de ocio, cultura y conocimiento.
Intrusos procesionales
Authors: Sánchez Guzmán Rubén , Fernández Paradas Antonio Rafael
Published: December 2022

En este trabajo estudiaremos la presencia de imágenes hagiográficas que se pueden considerar ajenas al ciclo de la Pasión de Cristo en las procesiones penitenciales españolas a lo largo de la historia, deteniéndonos fundamentalmente en aquellas que por méritos propios han sido merecedores de presidir un paso procesional en solitario.
Resiliencia urbana en pandemia por COVID-19 y lecciones aprendidas post pandemia
Authors: Arana Velarde Freddy , Uribe Hinostroza Marilú , Casas Vásquez María Cristina
Published: December 2022

El contexto de Pandemia inesperado y letal por Presencia de COVID-19 ocurrido en el presente milenio, pone en evidencia que la humanidad no estaba preparada para tamaño acontecimiento. El presente artículo evidencia que las ciudades como sistemas de hábitat humano, son precarios a nivel de organización, ordenamiento urbano, confort y seguridad; acompañado por entidades públicas y privadas ineficientes en la gestión urbana. En este contexto, el artículo expone el caso de la ciudad metropolitana de Huancayo, cuyas condiciones de ordenamiento urbano y resiliencia a la situación de emergencia vivida fue precaria y altamente ineficiente para responder a la emergencia.
actantes históricos en Ships in bottles de Neil Curry
Authors: Álvarez Castaño Emilio José
Published: December 2022

Los poemas históricos de Ships in Bottles de Neil Curry ofrecen una oportunidad de hacer una reflexión sobre la posible vigencia de la teoría del gran hombre. Contrasta la desconsideración que dicha aportación de Carlyle tiene en la actualidad con su seguimiento en otros campos, como los negocios o la política. En el caso de la poesía, los poemas seleccionados hacen ver de qué manera los grandes actantes de la historia conviven con las personas que hacen la microhistoria.
maternidad y el sistema de representación de la cultura cómica popular
Authors: Bogas Ríos María José
Published: December 2022

El presente texto es una investigación cualitativa de carácter exploratorio con método analítico-sintético y enfoque narratológico para indagar en las representaciones sobre la maternidad y el cuerpo gestante en el contexto de la cultura cómica popular a través de las dos primeras temporadas de la serie de Netflix, Emily en París. Los principales hallazgos son que la maternidad se inscribe en los márgenes tanto geográficos como discursivos del relato romántico amoroso dado en el paradigma representacional dominante de Francia y que el cuerpo gestante es representado a través de los rasgos del cuerpo grotesco presente en la cultura cómica popular.
Electronic literature as part of english literature
Authors: De Gregorio Robledo Yolanda
Published: December 2022

This essay introduces an approach to teach electronic literature in English Studies students; first introduces to the students what electronic literature is, that is, its main features, goals and genres. Secondly, it provides examples of women writers and their importance in the development of this kind of literature. Thirdly, it shows two electronic literary works written by women that may be part of the course’s core readings. This article dives into and breaks apart these literary texts through an introduction and a close reading of them.
documentación de teatro: el registro audiovisual de espectáculos teatrales
Authors: Linares Ávila Carlos
Published: December 2022

El presente trabajo analiza la labor de difusión del patrimonio escénico que lleva a cabo el Centro de Investigación y Recursos de las Artes Escénicas de Andalucía (CIRAE) a través de las videograbaciones disponibles en Elektra, el Archivo Digital de las Artes Escénicas de Andalucía. Para ello se analiza una muestra de 84 videograbaciones siguiendo una metodología cuantitativo-descriptiva. Los resultados del análisis muestran carencias relevantes en el fondo documental videográfico del archivo. Así, la investigación concluye una serie de puntos de mejora en la labor de difusión videográfica del patrimonio escénico andaluz llevada a cabo por el CIRAE.
Severini y la internacionalización de Valori Plastici
Authors: Mañero Cerutti Sofía
Published: December 2022

De entre todos los fascículos de la revista Valori Plastici llama la atención su número II-III. Mientras que la revista siempre se caracterizó por poner el foco en Italia, estenúmero se centra en el arte cubista francés. Se propone aquí como objetivo defender,mediante una metodología documental que aporta los documentos inéditosconsultados en el Archivio del 900’(MART), que fue precisamente Severini el encargado de realizar ese fascículo y que con ello instauró un corto período de relaciones entrelos artistas vinculados a los Valori Plastici y él mismo, con interesantes consecuencias para la comunicación entre los ámbitos artísticos italiano y francés.
Estudio del largometraje animado de la leyenda de La Llorona
Authors: Pomaquero-Yuquilema Mayra , Furió-Vita Dolores , López Izquierdo María Ángeles
Published: December 2022

Desde sus inicios, el cine estuvo fuertemente ligado con la literatura a partir de las adaptaciones de novelas, la divulgación del patrimonio literario, el análisis de la subjetividad, la teoría de los géneros, la aplicación de las categorías de la narratología para el estudio de las especificaciones fílmicas, entre muchos otros. Este estudio toma dos relatos literarios y los compara a través de orientaciones metodológicas y teóricas de la narratología con la versión animada de La Leyenda de la Llorona, para determinar similitudes y diferencias. Asimismo, analiza ciertos elementos del lenguaje cinematográfico que tienen concordancia con las obras literarias para entender que los vuelve diferentes y específicos.
Competencia digital del profesorado universitario
Authors: Cisneros-Barahona Andrés , Marqués Molías Luis , Samaniego Erazo Nicolay , Uvidia Fassler María , Castro-Ortiz Wilson , Rosas-Chávez Pablo
Published: December 2022

Se realizó una revisión sistemática de la literatura localizada en Scopus sobre la competencia digital (CD) del profesorado universitario; con ayuda de la metodología PRISMA y operadores se delimitó la investigación a través de tesauros de Eric. Los autores/entidades españolas resaltan en la temática, existen esfuerzos orientados al diseño, validación y aplicación de rúbricas a nivel mundial. Los abordajes predominantemente son cuantitativos. La investigación fortalece el entendimiento sobre la CD, existe un efecto positivo otorgado por las CD docentes en la formación de estudiantes, se requiere desarrollar planes de formación y emprender esfuerzos similares en otras bases de datos científicas.
Artificial intelligence in oncology: areas of application, prospects and limitations
Authors: Кульбакин Денис , Чойнзонов Евгений , Толмачев Иван , Стариков Юрий , Старикова Елена , Каверина Ирина
Published: December 2022

Современная медицина и онкология, в частности, находятся в шаге от широкого внедрения искусственного интеллекта в повседневную врачебную практику. В статье описаны наиболее удачные проекты, демонстрирующие участие искусственного интеллекта в диагностике и прогнозировании течения онкологических заболеваний. Проанализированы существующие системы принятия врачебных решений, включающие модули диагностики онкологических заболеваний на основе нейронных сетей. Впервые показаны ограничения применения искусственного интеллекта в онкологии и описаны способы их преодоления. Методы искусственного интеллекта доказали свою эффективность при анализе изображений (рентгеновских снимков, гистологических срезов) и могут применяться для поддержки принятия врачебных решений. Огромный массив накопленных знаний о молекулярно-биологической природе опухолей находит практическое применение для назначения лечения и прогноза течения заболевания за счет обработки алгоритмами машинного обучения. Искусственный интеллект может стать ключом к повышению эффективности оказания медицинской помощи при онкологических заболеваниях.
Melanoma, molecular and genetic aspects of etiopathogenesis: classification, epidemiology, risk factors, braf and nras mutations
Authors: Казубская Татьяна , Мехеда Лариса , Трофимов Евгений , Фомина Лилия Яшаровна , Харкевич Галина , Белышева Татьяна , Козлова Валентина , Сорокина София , Фридман Марина
Published: December 2022

Меланома относится к злокачественным опухолям со склонностью к раннему метастазированию и высокой смертностью, несмотря на современные возможности лечения. Развитие молекулярно-генетических технологий позволило выявить сложный мутационный состав, показавший внутриопухолевую микрогетерогенность меланомы, приводящий к трудности её лечения. Идентифицировано множество связанных с меланомой соматических и герминальных мутаций в генах, ряд которых, так называемые «драйверные гены», вероятнее всего включаются в опухолевую прогрессию и являются основными в молекулярной классификации меланомы. В обзоре представлены эпидемиологические,  клинические и патологические характеристики меланомы, проведен анализ факторов риска и генетических изменений в генах BRAF, NRAS, KIT, NF1, RAC1 для разных форм меланомы в зависимости от источника первичной опухоли (кожа, слизистые оболочки, оболочки глаза). Обсуждаются разнообразные онкогенные изменения в невусах и подтипах меланомы, связанных и не связанных с солнечной экспозицией. Приводятся данные о герминальных и соматических мутациях в генах CDKN2A, BAP1, TERT, MITF и др., обнаруженных в меланоме, анализ которых позволяет дополнить знания о причинных механизмах возникновения заболевания.
Oncological safety of oncoplastic surgery in breast cancer patients
Authors: Омарова Джанет , Зикиряходжаев Азизжон , Усов Федор , Хугаева Фатима , Дуадзе Илона , Босиева Алана , Куприянов Петр , Решетов Игорь , Каприн Андрей
Published: December 2022

Цель. Оценить онкологическую безопасность выполнения онкопластических резекций (ОПР) молочных желез у больных раком молочной железы.
Материалы и методы. Проведено ретропроспективное когортное контролируемое клиническое исследование с включением 400 больных раком молочной железы 0-IIIC стадий, которым с 2013 по 2020 годы выполнено органосохраняющие операции: онкопластические (n=200) и классические радикальные резекции (n=200).
Результаты. Группы проанализированы в соответствии с клиническими и патоморфологическими параметрами: достоверно значимые различия обнаружены при анализе менструального статуса, возраста, размера опухоли, ширины ближнего края резекции (p<0,05). Медиана наблюдения составила 49 месяцев. Частота рецидивирования после ОПР и классических органосохраняющих операций (ОСО) составила 8% и 2% соответственно (p=0,006). Шансы рецидива в группе классических ОСО были ниже в 4,261 раза по сравнению с группой ОПР (ОШ=0,235; 95% ДИ: 0,077-0,715). Статистически значимых различий в частоте прогрессирования и летальных исходов между двумя исследуемыми группами не выявлено. Показатели пятилетней выживаемости без локорегионального рецидива составили 91% и 97% в группах ОПР и классических ОСО соответственно. Достоверно значимых различий в общей и безрецидивной  выживаемости в группах не выявлено. Проанализировано влияние клинико-патоморфологических показателей на частоту рецидивирования. Факторами неблагоприятного прогноза явились отсутствие экспрессии рецепторов эстрогена и прогестерона (p<0,001), гормональной (p<0,001) и лучевой терапии (p=0,012), наличие низкодифференцированнанного рака (рG3=0,024), тройной негативный и нелюминальный Her2/neu-позитивный тип опухоли (p<0,001). Частота рецидивирования была выше при сохраненном менструальном статусе пациенток (р=0,004). Пациентки с диагностированным местным рецидивом были значимо моложе (р=0,001).
Выводы. Различий между показателями общей и безрецидивной выживаемости после ОПР и классических ОСО не выявлено. При планировании органосохраняющего хирургического лечения необходим индивидуализированный подход с учетом неблагоприятных прогностических факторов. Для изучения вопроса частоты рецидивирвания после онкопластических резекций требуется выполнение крупных клинических исследований.  
Ключевые слова: рак молочной железы, органосохраняющие операции, онкопластические резекции, радикальные резекции, рецидивы, безрецидивная выживаемость, факторы прогноза.
Capmatinib in patients with MET-positive advanced non-small cell lung cancer: analysis of the Russian cohort in the Geometry mono-1 study
Authors: Орлов Сергей , Мусаелян Арам , Кочесокова Джульетта , Одинцова Светлана , Загребин Федор , Тюрин Владислав , Майдин Михаил , Дегтярев Алексей , Имянитов Евгений
Published: December 2022

Введение. Капматиниб во II фазе исследования Geometry mono-1 продемонстрировал высокую противоопухолевую активность у пациентов с распространенным НМРЛ с мутацией в 14 экзоне гена MET (METex14), а также контролируемый профиль безопасности.
Цель. Оценка эффективности и безопасности капматиниба в российской подгруппе пациентов исследования Geometry mono-1.
Материалы и методы. В исследовании Geometry mono-1 пациенты распределены в зависимости от статуса MET (амплификация либо мутация METex14) и линии терапии. В российской подгруппе были включены пациенты, которым проводилось лечение капматинибом в качестве терапии первой и второй линии с мутацией METex14. Капматиниб назначался в дозе 400 мг два раза в сутки. В качестве первичной конечной точки использовалась частота объективных ответов (ЧОО) со стороны опухоли и частота клинической пользы (ЧКП), а ключевыми вторичными точками были продолжительность ответа, выживаемость без прогрессирования заболевания (ВБП), общая выживаемость (ОВ) и профиль безопасности.
Результаты. В анализ было включено 13 пациентов (4 мужчины и 9 женщин) в возрасте от 59 до 82 лет с метастатическим НМРЛ с мутацией METex14., что сопоставимо с демографическими характеристиками в общей популяции исследования Geometry mono-1. У пациентов, получавших капматиниб в 1 линии (n=6), ЧОО составила 50% (95% ДИ 11,8 – 88,2%) и ЧКП – 100% (95% ДИ 60,7 – 100,0%), а во 2 линии (n=7): ЧОО равна 14,3% (95% ДИ 0,4 – 57,9%), а ЧКП – 71,4% (95% ДИ 29,0 – 96,3%). Медиана длительности ответа независимо от линии терапии составила 5,7 месяцев (95% ДИ 2,2 – 21,2 месяца). Медиана ВБП при назначении капматиниба в 1 линии составила 21,3 месяца (95% ДИ 5,6 – 25,1 месяц), а во 2 линии– 3,5 месяца (95% ДИ 0,9 – 36,8 месяцев). Медиана ОВ в зависимости от линии терапии была следующей: в 1 – 21,3 месяца (95% ДИ 9,9 – 51,5 месяцев), а во 2– 24,6 месяцев (95% ДИ 0,9 – 36,8 месяцев). Наиболее частыми нежелательными явлениями (НЯ), обусловленными лечением, были периферические отеки (69,2%), гипокальциемия (53,8%), увеличение креатинина (46,2%); большинство из них- 1/2 степени токсичности.
Заключение. В российской популяции также был отмечен высокий ответ на лечение капматинибом, терапия сопровождалась хорошей переносимостью. Не выявлено каких-либо неожиданных НЯ.
Artificial intelligence in the diagnosis of benign skin tumors in pediatric patients. Neural network integration into a mobile app
Authors: Хабарова Рина , Кулева Светлана
Published: December 2022

Введение. Десятилетие назад искусственный интеллект (ИИ), в частности нейронные сети (НС), как диагностическая опция в практике врача казался лишь отдаленной перспективой. На сегодняшний день применение ИИ во всех сферах клинической и фундаментальной медицины является все более востребованным и ежедневно совершенствующимся подходом.
Цель исследования. Разработка НС и ее обучение распознаванию четырех типов доброкачественных меланоцитарных новообразований кожи, интеграция искусственного интеллекта в мобильное приложение.
Материал и методы. 600 пациентам детского возраста были проведены клиническое и дерматоскопическое исследования новообразований кожи. У части пациентов (n=65) элементы были удалены и патоморфологически верифицированы. В 43% (n=28) был выявлен дермальный невус, в 33,8% (n=22) ― сложный невус, в 10,8% (n=7) ― пиогенная гранулема, в 6,2% (n=4) ― невус Шпиц, по 3,1% (n=2) были вариантами голубой невус и меланома кожи. Семь пациентов с пиогенными гранулемами и 2 с меланомой были исключены из тестовой выборки во время обучения НС. В обучающей выборке была проведена аугментация, тем самым, база была увеличена с 600 до 1800 изображений. НС написана на языке программирования Python с использованием фрэймворка для машинного обучения TensorFlow 2.0. Архитектура сети основана на предварительно обученной модели «EfficientNet B7» с применением парадигмы «обучения с учителем».
Результаты. После периода обучения на тестовой когорте достигнута 83 % точность распознавания четырех типов меланоцитарных невусов. Несмотря на ограниченную выборку, чувствительность метода в зависимости от класса новообразования составила 100% (голубой невус), 73% (сложный невус), 93% (дермальный невус) и 75% (невус Шпиц), специфичность ― 98, 94, 82 и 98% соответственно. Помимо разработки и обучения искусственный интеллект интегрирован в мобильное приложение «KIDS NEVI», что обеспечило практическое применение метода.
Заключение. ИИ в качестве вспомогательного метода диагностики меланоцитарных новообразований кожи у детей и подростков продемонстрировал высокий потенциал. Несмотря на ограниченную выборку, в настоящем исследовании представлены большие достижения в информативности данной диагностической методики.
Opportunities for antitumor drugs replacement
Authors: Имянитов Евгений , Проценко Светлана , Семиглазова Татьяна
Published: December 2022

Выбор оптимальной тактики лекарственного лечения для онкологических пациентов зависит не только от сведений о потенциальной клинической эффективности тех или иных фармакологических субстанций, но и от целого ряда сопутствующих нюансов, в частности, перечня зарегистрированных медицинских показаний, стоимости препаратов и их фактической доступности. В случае невозможности использования общепринятых лекарственных схем возникает необходимость поиска альтернативных, схожих по эффективности способов лечения. В данной работе рассматриваются примеры потенциальной взаимозаменяемости противоопухолевых препаратов, а также обсуждаются возможности уменьшения стоимости терапии без ущерба для её клинической эффективности.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENDAPATAN UMKM PADA MASA PANDEMI COVID-19 TAHUN 2021
Authors: Rapii Muhammad , Riswanto Agus , Febriani Lia
Published: December 2022

At the global economic level, the Covid-19 pandemic has provided a very significant impact on the country's domestic economy and the existence of Small and Medium Micro Business (SMEs). The Organisation for Economic Co-operation and Development (OECD) stated that the pandemic has implications for the threat of a major crisis marked by the cessation of production activities in many countries, the reduction of public consumption, loss of cosumer confidence, and  stock crash which ultimately leads to uncertainty. This study aims to determine: (1) the effect of social distancing of income, (2) the effect of raw material prices of income, (3) the effect of technology of income, (4) the effect of consumption of income. This study was a causal research. The subjects were SMEs in the village of Sikur Induk as many as 50 SMEs. The sampling method was used Non Probability sampling technique. The technique of collecting data was used questionaires. Validity and reliability tests conducted on 50 people. Data analysis technique was used multiple linear regression. The results of this study indicated that(1) there is a negative the effect of social distancing of  income. Proved by a regression the value of t is greather than t table (-2,198 -2,014), (2) There is a positive effect of raw material prices of income. Proved by a regression the value of t is greather than t table (2,136 2,014), (3) there is a positive effect of technology of  income. Proved by a regression the value of t is greather than t table (3,708 2,014), (4) there is a negative effect of consumption of income. Proved by a regression the value of t is greather than t table (-2,863 -2,014), (5) there is a positive influence of social distancing, raw material prices, technology, and consumption of income. Proved by a regression the value of F is greather than F table (9,367 2,58).
SURVEI TINGKAT PEMAHAMAN MAHASISWA TERHADAP EKONOMI KREATIF
Authors: Nursita Lisa , Nurhalisyah Nurhalisyah , S Maghfira , Salma Andi
Published: December 2022

Penelitian ini bertujuan untuk mengetahui tingkat pemahaman terhadap konsep ekonomi kreatif. Ekonomi kreatif diharapkan dapat menjadi tulang punggung perekonomian Indonesia dimasa depan. Metode penelitian ini menggunakan pendekatan kuantitatif dengan jumlah sampel 98 mahasiswa Fakultas Tarbiyah dan Keguruan Universitas Islam Negeri Alauddin Makassar. Teknik pengumpulan data penelitian ini menggunakan angket melalui google form yang sebelumnya telah di uji validitas dan reliabilitas. Instrumen dibuat dengan menggunakan Skala Guttman dan Skala Likert. Adapun teknik analisis data yang digunakan dalam penelitian ini adalah metode survei yang hasilnya kemudian dikategorisasi. Hasil penelitian ini menunjukkan bahwa pemahaman konsep ekonomi kreatif pada mahasiswa Fakultas Tarbiyah dan Keguruan Universitas Islam Negeri Alauddin Makassar tergolong kategori sedang. Dapat dikatakan pencapaian pemahaman konsep ekonomi kreatif belum maksimal, maka diperlukan upaya untuk meningkatkan pemahaman mahasiswa dalam rangka menggerakkan minat berwirausaha yang kreatif.
Comparative Analysis of English and Japanese Compounds with a Somatic Component Derived from Phraseological Units
Authors:   Vladimir State University, Basova Tat’yana A.
Published: December 2022

The article focuses on cross-level products of phraseological derivation – English and Japanese compound words with a somatic component ‒ and analyses their structure. The issue of word boundaries in both languages is raised as there are various ways to set boundaries between phraseological units and their lexical derivatives depending on the understanding of the issue, especially regarding N + N and Adj + N units in English and N + no + N units in Japanese. The problem of the so-called open compounds in English is investigated, and two types of units that bear relation to this category are identified: 1) units, originally idioms, that have lost almost all signs of structural separateness, 2) units that were derived from idioms and allow three spellings (separate, hyphenated and closed), but have no phraseological past of their own. In Japanese, via analysing kinodoku (‘unfortunate’) and oku no te (‘trump card’) the signs of possessive compound lexicalization are explained. The main word-forming, morphological and phonetic features of such lexemes in both languages are found, i.e. common word-orming models: compounding, compounding in combination with affixation, and lexicalization of full phrases including function words. Moreover, Japanese derivatives manifest some unique characteristics: phonetic changes according to rendaku, compression of idiom-based compounds with a second noun component which limits their length to 4 moras, and the existence of lexemes derived from communicative phraseological units, namely, proverbs.
Spatial Organization of Gas Resources Development on the Arctic Shelf of the Russian Federation
Authors:   Luzin Institute for Economic Studies — Subdivision of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”, Shchegolkova Asya A.
Published: December 2022

Being strategic, the Arctic shelf is a region with an extremely low level of exploration. The undiscovered hydrocarbon resources on the Russian Arctic shelf exceed 90%. The long-term development of strategic programs and projects for the development of gas production on the shelf are constrained by insufficient technical accessibility of industrial development, as well as the difficulty of assessing the actual volume of initial potential oil and gas resources. The reproduction of free gas reserves has been assessed, the level of parity between production and growth of explored reserves has been determined. The state of the gas resources of the Arctic shelf was studied taking into account localization in oil and gas regions, which allowed to make a conclusion about the degree of exploration of the resource base and to identify the basis for the gas potential. The factors restraining the development of offshore projects were identified and analyzed. It was determined that offshore projects should be presented to investors with more attractive operational, technological and economic indicators than alternative onshore projects. The lack of tested methods for the development of hydrocarbons at superdeep depths under severe ice conditions does not allow to fully assessing the economic efficiency of offshore gas projects in the Arctic. It is concluded that within the resource base of Arctic offshore fields, it is necessary to allocate the static (probabilistic) potential of hydrocarbon resources of the Arctic region. The need to transform the Arctic foreign policy is identified.
PENGARUH SUPERVISI KEPALA SEKOLAH DAN KOMPETENSI PEDAGOGIK GURU TERHADAP KINERJA GURU SMKN 2 BALIKPAPAN
Authors: Pps Jurnalpps , ÔÇÄ Rusjanto , Prasetyo Indra , Hartati C. Sri
Published: December 2022

The study was conducted to determine the effect of principal supervision on teacher performance and the effect of pedagogic competence on teacher performance. In addition, to determine the simultaneous effect of principal supervision and pedagogic competence on teacher performance. The population of this study was 80 teachers of SMKN 2 Balikpapan as a sample taken according to the number of teachers in SMKN 2 Balikpapan. The results showed (1) there was a positive and significant effect of principal's supervision on performance (2) there was a positive and significant influence of teacher pedagogical competence on teacher performance (3) there was a positive and significant influence of principal's supervision and teacher's pedagogic competence on teacher performance. This shows that all the variables of the principal's supervision and the teacher's pedagogic competence have a significant simultaneous effect on the teacher's performance at SMKN 2 Balikpapan.
ANALISIS PENGARUH MOTIVASI, KOMITMEN DAN GAYA KEPEMIMPINAN KEPALA MADRASAH TERHADAP KINERJA GURU MADRASAH ALIYAH AL KAUTSAR PANDAAN KABUPATEN PASURUAN
Authors: Pps Jurnalpps , Suyuthi Akhmad Subhan , Prasetyo Indra , Indrawati Mei
Published: December 2022

The purpose of this study was to test the motivation, commitment and leadership style on the performance of Madrasah Aliyah Al Kautsar teachers partially and simultaneously. The population in this study were all teachers with a total of 31 respondents, and was a census sampling study. The results showed that either partially or simultaneously the variables of motivation, commitment and leadership style had a significant influence on the performance of Madrasah Aliyah Al Kautsar Pandaan teachers. In an effort to improve the performance of Madrasah Aliyah Al Kautsar teachers, it is by increasing motivation, commitment and leadership style, as well as evaluating performance results and providing awards for teachers.
UPAYA PENINGKATAN PROFESIONALISME GURU SMP IT AL AZHAR BOARDING SCHOOL BALIKPAPAN KALIMANTAN TIMUR
Authors: Pps Jurnalpps , Rochimi M. Abdurachman , Utari Woro
Published: December 2022

This study was to determine the professionalism of teachers and work culture and teacher performance at SMP IT Al Azhar Boarding School. It also aims to find out the school's efforts in improving the professionalism of SMP IT Al Azhar Boarding School teachers and to find out the supporting and inhibiting factors in increasing the professionalism of SMP IT Al Azhar Boarding School teachers. In this study there were 29 people as informants consisting of the Principal, Deputy Principal and all teachers of SMP IT Al Azhar Boarding School. This research was conducted at SMP IT AL Azhar Pondok Pesantren Balikpapan, East Kalimantan. The results of this study indicate that there are several supporting and inhibiting factors in efforts to increase teacher professionalism at SMP IT AL Azhar Balikpapan, all of which are part of the process towards an advanced school.
KONSEP IDEOLOGI POLITIK DALAM AL-QUR‘AN
Authors: Masyhuri Ahmad Ari
Published: December 2022

The political ideology in the Qur'an is a set of ideologies that believe that Islam should be a guideline for all aspects of human life, social, economic, political, cultural, and personal life. Also, the political ideology in the Qur'an can be seen from the basic principles that guide the development of a political system. The basic principles mentioned above include the obligation to realize the unity and integrity of the ummah, the obligation to hold deliberations in resolving problems, the obligation to carry out mandates and establish laws fairly, the obligation to obey Allah and the Prophet and Ulil Amri, resolving conflicts, maintaining state sovereignty, the obligation to prioritize peace rather than hostility, the obligation to increase vigilance in the field of defense and security, and the obligation to keep promises. This research method uses a qualitative type of literature review research. Sources of data are taken from literature reviews such as; relevant journals, books and references. The results of the study state that interactions that have religious connections and state ideology can strengthen the life of the nation and state in the form of creating an attitude of community tolerance, creating harmony, unity and unity and helping each other. The interaction of Pancasila ideology in the universal values of political ideology in the Qur'an can be studied in the five Pancasila precepts, namely Belief in One Almighty God, Just and Civilized Humanity, Indonesian Unity, Democracy Led by Wisdom in Deliberation/representation, and Justice. Social Services for All Indonesian People, is a reflection of the verses in the Al-Qur'an, that Pancasila is a political sub-ideology and the embodiment of Islamic teachings that originate from the Al-Qur'an.
Studi Pencemaran Tanah Sebagai Bahan Pengayaan Topik Teknologi Ramah Lingkungan untuk Siswa SMP
Authors: Widia Gusti  , Noni Noviana  , Rita Sartika  , Lia Anggraini  , Andika Pradipta  , Henny Johan
Published: December 2022

Lingkungan sebagai tempat tinggal dan berinteraksi bagi makhluk hidup, juga sebagai penyedia sumber daya yang dapat mendukung kesejahteraan masyarakat. Aktivitas manusia dalam pengelolaan lingkungan kurang memperhatikan kebersihan dan kurangnya kepedulian dapat menimbulkan masalah lingkungan. Salah satu akibatnya terjadi pencemaran tanah. Pencemaran ini dapat memberikan dampak buruk kepada makhluk hidup terutama kesehatan. Sehingga perlu untuk membekalkan sikap literasi lingkungan. Peran pendidik dalam hal ini bisa dengan mengintegrasikan konteks pencemaran dan pengelolaan lingkungan kedalam topik pembelajaran. Penelitian ini dilakukan dengan observasi langsung di lapangan untuk memperoleh data kuantitatif pencemaran tanah terhadap beberapa objek di Kota Bengkulu. Kemudian dilakukan metode deskriptif untuk mengumpulkan referensi terkait pengitegrasian topik dalam pengayaan sesuai dengan KD pembelajaran. Integrasi dalam pembelajaran IPA yang diharapkan dapat membekalkan literasi lingkungan kepada siswa. Berdasarkan hasil observasi, sumber pencemaran tanah yang paling umum adalah tumpukan sampah yang berasal dari limbah rumah tangga, aktivitas perdagangan/pasar, dan rumah industri. Konten pembelajaran yang dapat diintegrasikan pada pembelajaran mengarah pada pengaplikasian teknologi ramah lingkungan dalam pengelolaan sampah. Metode landfill merupakan salah satu teknologi ramah lingkungan yang menerapkan teknologi tepat guna dalam pengelolaan sampah di TPA.
Improvement of Manufacturing Industry Work Environment Using Signage: Root Industry
Authors: Oh Kyungjin , Lee Nayoung , Chung Daekwon , Woo Jinho , Shin Haeyeon , Kim Hunseop , Lee Ho Seong , Kim San , Moon SangJun , Chu Won-Shik
Published: December 2022

Small and Medium-sized Enterprises (SMEs) in Korea are faced with developments and improvements due to the 4th Industrial Revolution. Adopting new technologies into the enterprise and improving safety in the factory were the main issues for all SMEs in Korea. For that working environment would play the most important role in the industry. In this study, the ‘working environment improvement model’ based on signage was applied to SMEs (root enterprises), and its usability was evaluated. The evaluation index consisted of five categories: ‘Visualization (number, color, compartment),’ ‘5S (sort, set in order, shine, standardize, sustain),’ ‘Safety (fire, hazard/hazardous substance, health and facility, electricity, safety (education)),’ ‘Management system (production, quality, logistics, safety/environment (cognition)),’ and ‘Leadership & Strategy (management's will and strategy).’ Six enterprises in four different root industries were evaluated based on the evaluation index by applying the working environment improvement model. They assessed the satisfaction of the model (before and after). Satisfaction increased across all indicators, and the need and usability of the workplace improvement model were positive, but there were also some limitations in its application.
Uniqueness of the Legacy of the Munich Central Collecting Point of the Defeated Germany (1945–9)
Authors: Soloshenko Viktoriia
Published: December 2022

The article highlights that the problem of restitution of cultural valuables lost in connection with World War II has been a matter of concern for humanity for many decades. Most European countries have no choice but to address such issues in order to move on from those tragic pages of history and discern crucial lessons for the future.
The author reveals that the territories of European countries suffered such an unprecedented and total relocation of objects of culture, equivalents of which are hardly present in the recent history of European civilisation. It is proven that the issue of defending, preserving, and reclaiming cultural valuables stolen by the Nazis at the onset of and throughout World War II has been reinvented by German society. The paper highlights Germany’s considerable experience in overcoming the burden of the past.
The article analyses the history of the creation and operation of the Munich Central Collecting Point. It outlines the interaction between American and German fellow art experts in the employ of Munich Central Institute of Art, which was overall positive. The author accentuates the problem of cultural valuables, which in the wake of World War II ended up scattered across the world, having been trafficked from Germany, Austria, Poland, Ukraine, etc., transported, or otherwise permanently lost. The contractual framework enabling the protection of cultural heritage is outlined, and the cases of recovery and restitution of cultural valuables transported or lost during World War II are showcased. The central problems impeding or limiting such recovery and restitution are discovered. Finally, the author analyses the German experience of recent decades in recovery and restitution of lost or illegally trafficked works along with the significance of that experience to Ukraine.
Keywords: Munich Central Collecting Point, Germany, totalitarian past, Nazi policy, cultural valuables, restitution.