bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of INTACT (INcisionless TArgeted Core Tissue) biopsy procedure for perinatal autopsy
Authors: Shelmerdine S. C. , Hutchinson J. C. , Ward L. , Sekar T. , Ashworth M. T. , Levine S. , Sebire N. J. , Arthurs O. J.
Published: July 2019

Objectives

To determine the feasibility and tissue yield of a perinatal incisionless ultrasound‐guided biopsy procedure, the INcisionless Targeted Core Tissue (INTACT) technique, in the context of minimally invasive autopsy.

Methods

Cases of perinatal death in which the parents consented for minimally invasive autopsy underwent postmortem magnetic resonance imaging and an INTACT biopsy procedure, defined as needle biopsy of organs via the umbilical cord, performed under ultrasound guidance. In each case, three cores of tissue were obtained from seven target organs (both lungs, both kidneys, heart, spleen and liver). Biopsy success was predefined as an adequate volume of the intended target organ for pathological analysis, as judged by a pathologist blinded to the case and biopsy procedure.

Results

Thirty fetuses underwent organ sampling. Mean gestational age was 30 weeks (range, 18–40 weeks) and mean delivery‐to‐biopsy interval was 12 days (range, 6–22 days). The overall biopsy success rate was 153/201 (76.1%) samples, with the success rates in individual organs being highest for the heart and lungs (93% and 91%, respectively) and lowest for the spleen (11%). Excluding splenic samples, the biopsy success rate was 150/173 (86.7%). Histological abnormalities were found in 4/201 (2%) samples, all of which occurred in the lungs and kidneys of a fetus with pulmonary hypoplasia and multicystic kidney disease.

Conclusions

Incisionless ultrasound‐guided organ biopsy using the INTACT procedure is feasible, with an overall biopsy success rate of over 75%. This novel technique offers the ideal combination of an imaging‐led autopsy with organ sampling for parents who decline the conventional invasive approach. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
Synthesis and Characterization of the Manganese Hydroxide Halides Mn(OH)X (X = Br, I) and Crystal Structure of trans‐MnBr2·4H2O
Authors: Falkowski Viktoria , Zeugner Alexander , Isaeva Anna , Wurst Klaus , Ruck Michael , Huppertz Hubert
Published: July 2019

The pale‐pink, hygroscopic compounds Mn(OH)X (X = Br, I) were obtained by high‐pressure synthesis in a Walker‐type multianvil apparatus. They crystallize in the space group P21/c with a = 640.48(3), b = 698.80(3), c = 615.54(2) pm, β = 110.30(1)° at 183(1) K (X = Br), and a = 686.18(3), b = 713.08(3), c = 637.18(3) pm, β = 109.51(1)° at 150(1) K (X = I). The crystal structures are isotypic to Cu(OH)Cl and consist of edge‐sharing distorted Mn(OH)3X3 octahedra arranged in sheets parallel to the bc‐plane. Spin‐polarized scalar‐relativistic DFT+U calculations predict an intrinsic magnetic insulating state (ca. 3.5 eV bandgap) that is proximate to frustration. Calculated effective magnetic moments equal to 4.34 μB/f.u. for Mn(OH)Br and 4.33 μB/f.u. for Mn(OH)I. FT‐IR spectroscopy confirmed interlayer hydrogen bonding. As a side result of the experiments, the compound trans‐MnBr2·4H2O was obtained. It crystallizes in the space group Cmcm with a = 438.64(2), b = 1167.84(6), and c = 730.95(4) pm.
Climate-Smart Potatoes
Authors: Reay Dave
Published: July 2019

For a long time, Europe, North America and the former Soviet Union were the powerhouses of world potato growing. Since the 1960s, though, production in Asia, Africa and Latin America has more than quadrupled, and China and India between them now grow over one-third of the enormous 350 million tonne global potato harvest. Every tonne of raw chips has a carbon footprint of just under a tonne of greenhouse gas emissions. Each year in the UK, we discard some 320,000 tonnes that could have been eaten. This veritable mountain of dumped potatoes represents an annual climate penalty of well over 80,000 tonnes of greenhouse gas emissions. Drought is a major risk for many growers, as few in the UK use irrigation, and the viable area of rain-fed potatoes could shrink to 5 per cent of its current extent as droughts intensify in twenty-first-century Britain. Diseases such as late blight also pose a big threat for growers around the world. A combination of disease and drought-resistant varieties, along with irrigation, soil management and greater farm nutrient efficiency can deliver much greater resilience and more secure yields, while driving down emissions.
Conclusion
Authors: Reay Dave
Published: July 2019

Just one day’s food and drink has together travelled over 40,000 miles and encompassed a wide array of climate change risks and responses. Their carbon footprints also ranged widely, with milk, chicken and fried food standing out as the biggest overall, but with tea and coffee having very high emissions for each gram actually consumed. On-farm emissions and those from storage and cooking dominate life-cycle emissions for most foods. All face threats from climate change, with many smallholders around the world facing the prospect of losing their livelihoods altogether as impacts intensify. Every food and drink examined, however, has a raft of climate-smart responses available that could boost resilience and yields, and lower emissions. Engaging with stakeholders, especially the people who produce our food, and taking local contexts into account when designing and applying solutions for food in a changing climate is the fundamental take-home message.
Climate-Smart Orange Juice
Authors: Reay Dave
Published: July 2019

Our daily glass of orange juice has travelled a long way to the breakfast table. Travel is part of its carbon footprint, but growing the oranges in the first place dominates emissions. Each glass has a total footprint of around 200 grams. In the UK we waste approximately 50,000 tonnes of orange juice each year—reducing household waste and improving the efficiency of water and fertiliser use on farms stand out as ways to cut the carbon footprint of orange juice. Growers in Brazil and the US are battling citrus greening disease and those in Florida have been devastated by frost damage in the past. In the future, climate change is set to bring greater pest and disease risks alongside drought and heat-stress issues. Strategies such as irrigation, soil moisture management and biological pest control all emerge as potentially powerful climate-smart solutions, but for some orange farmers abandoning orange growing altogether may be the only long-term answer.
Climate-Smart Tea
Authors: Reay Dave
Published: July 2019

Tea is second only to water as the world’s most popular drink. Total production has grown to around 5 million tonnes a year, with the industry as a whole valued at $20 billion. Its carbon footprint totals 25 grams of emissions per comforting cup, mainly the energy used to boil water. In the UK almost 60,000 tonnes is wasted each year simply because too much was made or it went cold before we could drink it. Tea plants face climate risks from flood, drought and heat, as well as from increases in disease and pest attack, such as the already highly damaging tea mosquito bug. The use of agroforestry, soil management and carefully planned drainage can all help increase resilience to severe weather impacts. New tea varieties also offer the chance to increase disease resistance. Moving cultivation to new areas is likely to be the only option in some areas as the climate envelop for tea shifts further in the coming decades
Climate-Smart Milk
Authors: Reay Dave
Published: July 2019

Global average milk consumption per person now tops 100 kilograms a year. In the US and across much of Europe we put away well over double this average. Some 700 million tonnes is produced worldwide annually with the UK being a net exporter of milk products and boasting a dairy herd numbering almost two million cows. Cows are a major source of the powerful greenhouse gas methane. Each litre of fresh milk we purchase is responsible for the equivalent of 3 kilograms of greenhouse emissions—over half a kilogram per standard glass. Milk is one of the most wasted foods in the UK at 290,000 tonnes each year. Reduced wastage by households is therefore central to reducing milks carbon footprint. On farms, improved animal health can provide major emissions benefits, as can alterations in feed. Higher temperatures pose a risk to yields and may increase milk spoilage. Fodder quality is also likely to be reduced in a future climate while some major diseases like Blue Tongue could benefit from warming and changing rainfall patterns.
Climate-Smart Chocolate
Authors: Reay Dave
Published: July 2019

Ghana, Ivory Coast and Indonesia are the major cocoa producers, with smallholder farmers in West Africa being responsible for around 60 per cent of global supply. Each year in the UK alone we consume around 500,000 tonnes of chocolate as bars and drinks, in cakes and biscuits. The average 40-gram bar of milk chocolate will carry with it a carbon footprint of around 200 grams. In the UK an estimated 18,000 tonnes of chocolate and sweets are wasted each year, responsible for around 90,000 tonnes of greenhouse gas emissions. High temperatures and drought can have severe impacts on cocoa yields, with Ghana likely to see suitable areas for cocoa pushed south as more northern areas become drier and hotter. Diseases like cocoa swollen shoot virus are already a major concern with around 300 million trees thought to be infected. Rehabilitation and renovation of existing cocoa plantations is at the heart of building resilience to climate change and securing the millions of livelihoods that depend on cocoa.
Climate-Smart Chicken
Authors: Reay Dave
Published: July 2019

In the 1960s average yearly consumption of poultry meat stood at just over 3 kilograms per person on the planet. By the 1990s this had more than tripled, and by 2030 we are each predicted to be eating the equivalent of 17 kilograms of poultry meat a year (over 120 million tonnes worldwide). For every kilogram of chicken produced, up to 5 kilograms of greenhouse gas is emitted. Within this, producing the chicken feed is the main culprit at about three-quarters of the total. Each year in UK households, we waste 110,000 tonnes of chicken meat. In the developed world most chicken is produced under controlled conditions, so heat stress risks under a changing climate should be minimal. However, cooling capacities, transport systems and housing densities all need to be adapted as the risk of more extreme heat events increases. In the developing world chickens may be more exposed to severe weather impacts, but they also represent a useful way to enhance incomes and food security where resilient and higher-yielding varieties are made available.
Deep learning–based prediction model of occurrences of major adverse cardiac events during 1-year follow-up after hospital discharge in patients with AMI using knowledge mining
Authors: Kim Young Joong , Saqlian Muhammad , Lee Jong Yun
Published: July 2019

Traditional regression-based approaches do not provide good results in diagnosis and prediction of occurrences of cardiovascular diseases (CVD). Therefore, the goal of this paper is to propose a deep learning–based prediction model of occurrence of major adverse cardiac events (MACE) during the 1, 6, 12 month follow-up after hospital admission in acute myocardial infarction (AMI) patients using knowledge mining. We used the Korea Acute Myocardial Infarction Registry (KAMIR) dataset, a cardiovascular disease database registered in 52 hospitals in Korea between 1 January, 2005, and 31 December, 2008. Among 14,885 AMI patients, 10,813 subjects in age from 20 to 100 years with the 1-year follow-up traceability without coding errors were finally selected. For our experiment, the training/validation/test dataset split is 60/20/20 by random sampling without replacement. The preliminary deep learning model was first built by applying training and validation datasets and then a new preliminary deep learning model was generated using the best hyperparameters obtained from random hyperparameter grid search. Lastly, the preliminary prediction model of MACE occurrences in AMI patients is evaluated by test dataset. Compared with conventional regression-based models, the performances of machine/deep learning–based prediction models of the MACE occurrence in patients with AMI, including deep neural network (DNN), gradient boosting machine (GBM), and generalized linear model (GLM), are also evaluated through a matrix with sensitivity, specificity, overall accuracy, and the area under the ROC curve (AUC). The prediction results of the MACE occurrence during the 1, 6, and 12-month follow-up in AMI patients were the AUC of DNN (1 M 0.97, 6 M 0.94, 12 M 0.96), GBM (0.96, 0.95, 0.96), and GLM (0.76, 0.67, 0.72) in machine learning–based models as well as GRACE (0.75, 0.72, 0.76) in regression model. Compared with previous models, our deep learning–based prediction models significantly had the accuracy of 95% or higher and outperformed all machine learning and regression-based prediction models. This paper was the first trial of deep learning–based prediction model of the MACE occurrence in AMI clinical data. We found that the proposed prediction model applied different risk factors except the attribute “age” by using knowledge mining and directly used the raw data as input.
Tensions Between Ethics and the Law: Examination of a Legal Case by Two Midwives Invoking a Conscientious Objection to Abortion in Scotland
Authors: Fleming Valerie , Frith Lucy , Ramsayer Beate
Published: July 2019

This paper examines a legal case arising from a workplace grievance that progressed to being heard at the UK’s Supreme Court. The case of Doogan and Wood versus Greater Glasgow and Clyde Health Board concerned two senior midwives in Scotland, both practicing Roman Catholics, who exercised their perceived rights in accordance with section 4(1) of the Abortion Act not to participate in the treatment of women undergoing abortions. The key question raised by this case was: “Is Greater Glasgow and Clyde Health Board entitled to require the midwives to delegate, supervise and support staff in the treatment of patients undergoing termination of pregnancy?” The ethical issues concerning conscientious objection to abortion have been much debated although the academic literature is mainly concerned with the position of medical practitioners rather than what the World Health Organization terms “mid-level professionals” such as midwives. This paper examines the arguments put forward by the midwives to justify their refusal to carry out tasks they felt contravened their legal right to make a conscientious objection. We then consider professional codes, UK legislation and church legislation. While the former are given strong weighting the latter was been ignored in this case, although cases in other European countries have been prevented from escalating to such a high level by the intervention of prominent church figures. The paper concludes by stating that the question put to the courts remains as yet unanswered but offers some recommendations for future policy making and research.
Spectral structure of the Neumann–Poincaré operator on tori
Authors: Ando Kazunori , Ji Yong-Gwan , Kang Hyeonbae , Kawagoe Daisuke , Miyanishi Yoshihisa
Published: July 2019

We address the question whether there is a three-dimensional bounded domain such that the Neumann–Poincaré operator defined on its boundary has infinitely many negative eigenvalues. It is proved in this paper that tori have such a property. It is done by decomposing the Neumann–Poincaré operator on tori into infinitely many self-adjoint compact operators on a Hilbert space defined on the circle using the toroidal coordinate system and the Fourier basis, and then by proving that the numerical range of infinitely many operators in the decomposition has both positive and negative values.
Analysis of births, abortions and maternal mortality in adolescents in Ecuador from 2013 to 2016
Authors: García Mónica , Acurio María Luciana Armijos , Sotomayor Ruth Jimbo , Sanchez Xavier , Guijarro Susana
Published: July 2019

Introduction:

Adolescent pregnancy is associated to school desertion, violence, termination of pregnancy under suboptimal conditions, obstetric complications and other consequences that can put the woman's quality of life at risk and of those that surround her. The purpose of this study is to describe the situation and tendencies of adolescent pregnancies, abortions and maternal deaths between 2013 and 2016 in Ecuador.

Methods:

This cross-sectional study uses secondary data from national Ecuadorian vital statistics reports of adolescents between 10 and 19 years old. The data sources used register all the births, deaths and hospital discharges in the country at both public and private health establishments. We performed a descriptive analysis of qualitative and quantitative variables.

Results:

Ecuador has approximately 1.5 million female adolescents that gave birth to 256,561 newborns between 2013 and 2016, resulting in an average annual birth rate in early adolescence of 13.9 live births per 1000 and in late adolescence of 86.6 per 1000 live births.

The number of registered abortions among adolescents between 2013 and 2016 was of 19,214. The estimated annual abortion rate in late stage adolescents is 6.3 abortions per 1000 women between 15 and 19. The estimated abortion ratio for this same age group is 72.9 per 1000 live births.

Of all the adolescents that gave birth, 84.9% self-identified as mestiza, while 71.9% of Ecuador's general population identifies as such. Only 7% of the general population in Ecuador self-identifies as indigenous, while 21.6% of pregnancies come from this population. Out of all adolescents that gave birth, 57.4% of those aged 17 and over; 43% of those between 14 and 16 and 96.7% of adolescents from 10 to 13, completed the level of education for their age. There were 81 maternal deaths among this group. The maternal mortality rate for late stage adolescents is of 7.72 per 100,000.
Characteristics and etiologies of short stature in children
Authors: Essaddam Leïla , Kallali Wafa , Cherifi Emna , Guedri Rahma , Mattoussi Nadia , Fitouri Zohra , Becher Saayda Ben
Published: July 2019

Background:

Short stature is a common reason for referral to pediatric endocrinology clinics. It may be a manifestation of a pathological condition requiring early treatment. The aim of this study was to describe the characteristics and etiologies of short stature among children referred to the pediatric endocrinology clinic of the main pediatric tertiary care center in Tunisia.

Methods:

Retrospective and descriptive study in the endocrinology unit of children referred for short stature between January 2012 and December 2016. Data on the patients' medical history, physical findings, laboratory tests, bone age and chromosomal analysis were collected.

Results:

470 children (266 males and 204 females) were referred during that period. 214 (45.5%) had normal height, and 80.8% of them were referred by general practitioners. The other 256 children (54.5%) had a confirmed short stature (mean age :7.2 years, mean height: -2.77 SDS). Endocrinological causes were the most common(43% GHD, 4% hypothyroidism) followed by intrauterine growth retardation IUGR (24%), genetic syndromes (8.4%), chronic pediatric diseases (7.8%), skeletal dysplasia (6.2%), normal variant of short stature (5%), and psychosocial deprivation (1.2%). Among non-endocrine causes, Turner syndrome was the most common genetic syndrome (4.4%), achondroplasia the main skeletal dysplasia (4%) and celiac disease the main chronic disease (3.4%).

Conclusions:

ST is largely overestimated in our country. Therefore, it is important to insist on adequate measurement and analysis of growth parameters to avoid unnecessary investigations. GHD and IUGR were the most common causes. Celiac disease, though frequent in Tunisia, is not a common cause of short stature.
When the Problem Became the Solution
Authors: Shemesh Ari , Al-Shafai Laila , Krings Timo , Margolin Edward
Published: July 2019

We present a unique case where a young man developed subtle cavernous sinus thrombosis (CST) due to underlying hypercoagulable state. He also had coexisting frontal lobe brain dural arteriovenous fistula (bdAVF). After CST developed, venous drainage from the optic nerve was redirected into the frontal lobe which was already under high venous pressure because of preexisting bdAVF. This caused backflow of venous blood into the optic nerve causing massive persistent optic nerve head swelling. Presumed acute venous hypertension event within bdAVF caused frontal mass effect presenting as seizure leading to thrombosis of bdAVF.
Undulatory and oscillatory swimming
Authors: Smits Alexander J.
Published: July 2019

Theory and modelling remain central to improving our understanding of undulatory and oscillatory swimming. Simple models based on added mass can help to give great insight into the mechanics of undulatory swimming, as demonstrated by animals such as eels, stingrays and knifefish. To understand the swimming of oscillatory swimmers such as tuna and dolphins, models need to consider both added mass forces and circulatory forces. For all types of swimming, experiments and theory agree that the most important velocity scale is the characteristic lateral velocity of the tail motion rather than the swimming speed, which erases to a large extent the difference between results obtained in a tethered mode, compared to those obtained using a free swimming condition. There is no one-to-one connection between the integrated swimming performance and the details of the wake structure, in that similar levels of efficiency can occur with very different wake structures. Flexibility and viscous effects play crucial roles in determining the efficiency, and for isolated propulsors changing the profile shape can significantly improve both thrust and efficiency. Also, combined heave and pitch motions with an appropriate phase difference are essential to achieve high performance. Reducing the aspect ratio will always reduce thrust and efficiency, but its effects are now reasonably well understood. Planform shape can have an important mitigating influence, as do non-sinusoidal gaits and intermittent actuation.
Turbulent temperature fluctuations in a closed Rayleigh–Bénard convection cell
Authors: Wang Yin , He Xiaozhou , Tong Penger
Published: July 2019

We report a systematic study of spatial variations of the probability density function (PDF) $P(\unicode[STIX]{x1D6FF}T)$ for temperature fluctuations $\unicode[STIX]{x1D6FF}T$ in turbulent Rayleigh–Bénard convection along the central axis of two different convection cells. One of the convection cells is a vertical thin disk and the other is an upright cylinder of aspect ratio unity. By changing the distance $z$ away from the bottom conducting plate, we find the functional form of the measured $P(\unicode[STIX]{x1D6FF}T)$ in both cells evolves continuously with distinct changes in four different flow regions, namely, the thermal boundary layer, mixing zone, turbulent bulk region and cell centre. By assuming temperature fluctuations in different flow regions are all made from two independent sources, namely, a homogeneous (turbulent) background which obeys Gaussian statistics and non-uniform thermal plumes with an exponential distribution, we obtain the analytic expressions of $P(\unicode[STIX]{x1D6FF}T)$ in four different flow regions, which are found to be in good agreement with the experimental results. Our work thus provides a unique theoretical framework with a common set of parameters to quantitatively describe the effect of turbulent background, thermal plumes and their spatio-temporal intermittency on the temperature PDF $P(\unicode[STIX]{x1D6FF}T)$.
Flow instabilities in the wake of a circular cylinder with parallel dual splitter plates attached
Authors: Wang Rui , Bao Yan , Zhou Dai , Zhu Hongbo , Ping Huan , Han Zhaolong , Serson Douglas , Xu Hui
Published: July 2019

In this paper, instabilities in the flow over a circular cylinder of diameter $D$ with dual splitter plates attached to its rear surface are numerically investigated using the spectral element method. The key parameters are the splitter plate length $L$, the attachment angle $\unicode[STIX]{x1D6FC}$ and the Reynolds number $Re$. The presence of the plates was found to significantly modify the flow topology, leading to substantial changes in both the primary and secondary instabilities. The results showed that the three instability modes present in the bare circular cylinder wake still exist in the wake of the present configurations and that, in general, the occurrences of modes A and B are delayed, while the onset of mode QP is earlier in the presence of the splitter plates. Furthermore, two new synchronous modes, referred to as mode A$^{\prime }$ and mode B$^{\prime }$, are found to develop in the wake. Mode A$^{\prime }$ is similar to mode A but with a quite long critical wavelength. Mode B$^{\prime }$ shares the same spatio-temporal symmetries as mode B but has a distinct spatial structure. With the exception of the case of $L/D=0.25$, mode A$^{\prime }$ persists for all configurations investigated here and always precedes the transition through mode A. The onset of mode B$^{\prime }$ occurs for $\unicode[STIX]{x1D6FC}>20^{\circ }$ with $L/D=1.0$ and for $L/D>0.5$ with $\unicode[STIX]{x1D6FC}=60^{\circ }$. The characteristics of all the transition modes are analysed, and their similarities and differences are discussed in detail in comparison with the existing modes. In addition, the physical mechanism responsible for the instability mode B$^{\prime }$ is proposed. The weakly nonlinear feature of mode B$^{\prime }$, as well as that of mode A$^{\prime }$, is assessed by employing the Landau model. Finally, selected three-dimensional simulations are performed to confirm the existence of these two new modes and to investigate the nonlinear evolution of the three-dimensional modes.
Incidental finding of mastoid opacification in computed tomography imaging of the asymptomatic paediatric population
Authors: Placanica T , Anderson S
Published: July 2019

Background

Acute mastoiditis is a clinically diagnosed suppurative infection of the mastoid air cells and is the most common complication of acute otitis media. Opacification of the mastoid air cells is a commonly reported radiological finding and patients are often erroneously diagnosed with acute mastoiditis when this is present.

Objectives

This study aimed to quantify incidental findings of mastoid opacification in the asymptomatic paediatric population and contribute to the epidemiological data.

Method

A retrospective cohort study was conducted of all paediatric patients who underwent relevant computed tomography imaging for a non-otological indication.

Results

Data were collected from 767 patients in total. Mastoid opacification was reported in 82 patients. The prevalence was highest in patients aged zero to one year (n = 25, prevalence = 20.3 per cent), followed by those aged two to three years (n = 17, prevalence = 19.5 per cent).

Conclusion

Mastoid opacification is a common incidental finding in the asymptomatic paediatric population, with prevalence rates between 5 per cent and 20 per cent depending on age. The prevalence peaks in patients aged zero to four years (19–20 per cent) and is inversely correlated with increasing age.
Long-term outcomes of ossiculoplasty using bone cement
Authors: Demir B , Binnetoglu A , Sahin A , Derinsu U , Batman Ç
Published: July 2019

Objective

This study aimed to evaluate the long-term results of ossiculoplasty using bone cement.

Method

Forty patients (24 females and 16 males; mean age: 34.1 ± 11.8 years; range, 9–54 years) with chronic otitis media with perforation but without cholesteatoma who had undergone incudostapedial rebridging ossiculoplasty using bone cement were evaluated retrospectively. Pre-operative and post-operative audiograms were evaluated. Bone conduction, air conduction and air–bone gaps were calculated according to international guidelines.

Results

There was a mean reduction in pre-operative and post-operative air conduction (12.30 ± 11.98 dB), and this result was significant (p = 0.0001). There was a mean reduction in pre-operative and post-operative bone conduction (4.30 ± 6.69 dB), and this result was significant (p < 0.0001). The pre-operative air–bone gap was 27.65 dB and decreased to 19.65 dB during follow-up (p = 0.0001). No adverse reactions or complications were observed.

Conclusion

Bone cement is reliable for the repair of incudostapedial-joint defects.
Modeling Ocean Eddies on Antarctica's Cold Water Continental Shelves and Their Effects on Ice Shelf Basal Melting
Authors: Mack Stefanie L. , Dinniman Michael S. , Klinck John M. , McGillicuddy Dennis J. , Padman Laurence
Published: July 2019

Changes in the rate of ocean‐driven basal melting of Antarctica's ice shelves can alter the rate at which the grounded ice sheet loses mass and contributes to sea level change. Melt rates depend on the inflow of ocean heat, which occurs through steady circulation and eddy fluxes. Previous studies have demonstrated the importance of eddy fluxes for ice shelves affected by relatively warm intrusions of Circumpolar Deep Water. However, ice shelves on cold water continental shelves primarily melt from dense shelf water near the grounding line and from light surface water at the ice shelf front. Eddy effects on basal melt of these ice shelves have not been studied. We investigate where and when a regional ocean model of the Ross Sea resolves eddies and determine the effect of eddy processes on basal melt. The size of the eddies formed depends on water column stratification and latitude. We use simulations at horizontal grid resolutions of 5 and 1.5 km and, in the 1.5‐km model, vary the degree of topography smoothing. The higher‐resolution models generate about 2–2.5 times as many eddies as the low‐resolution model. In all simulations, eddies cross the ice shelf front in both directions. However, there is no significant change in basal melt between low‐ and high‐resolution simulations. We conclude that higher‐resolution models (<1 km) are required to better represent eddies in the Ross Sea but hypothesize that basal melt of the Ross Ice Shelf is relatively insensitive to our ability to fully resolve the eddy field.
The Challenge of Machine Learning in Space Weather: Nowcasting and Forecasting
Authors: Camporeale E.
Published: July 2019

The numerous recent breakthroughs in machine learning make imperative to carefully ponder how the scientific community can benefit from a technology that, although not necessarily new, is today living its golden age. This Grand Challenge review paper is focused on the present and future role of machine learning in Space Weather. The purpose is twofold. On one hand, we will discuss previous works that use machine learning for Space Weather forecasting, focusing in particular on the few areas that have seen most activity: the forecasting of geomagnetic indices, of relativistic electrons at geosynchronous orbits, of solar flares occurrence, of coronal mass ejection propagation time, and of solar wind speed. On the other hand, this paper serves as a gentle introduction to the field of machine learning tailored to the Space Weather community and as a pointer to a number of open challenges that we believe the community should undertake in the next decade. The recurring themes throughout the review are the need to shift our forecasting paradigm to a probabilistic approach focused on the reliable assessment of uncertainties, and the combination of physics‐based and machine learning approaches, known as gray box.
Sediments in Agricultural Reservoirs Act as Sinks and Sources for Nutrients over Various Timescales
Authors: Shaughnessy A.R. , Sloan J.J. , Corcoran M.J. , Hasenmueller E.A.
Published: July 2019

Reservoirs along rivers have the potential to act as nutrient sinks (e.g., denitrification and sedimentation) or sources (e.g., decomposition and redox changes), potentially reducing or enhancing nutrient loads downstream. This study investigated the spatial and temporal variability of water and lakebed sediment chemistry for an agricultural reservoir, Carlyle Lake (Illinois, U.S.), to assess the role of sediments as nutrient sinks or sources. Samples were collected across the reservoir over a 2‐year period. We measured N‐ and P‐species in water at the sediment‐water interface, in sediment porewaters, and loosely bound to sediment exchange sites. Total N, total P, total C, organic matter, Fe, Mn, and grain size were measured in bulk sediments. We observed a strong gradient in sedimentary total N, total P, total C, organic matter, and metals along the reservoir, with the lowest concentrations at the river mouth and the highest concentrations near the dam. Additionally, we did a long‐term nutrient mass balance using historical water quality data for streams entering and exiting the reservoir and the reservoir itself. Mass balance calculations showed that Carlyle Lake, on average, removed 2,738 Mg N/year and released 121 Mg P/year over the multidecadal observation period. While N was consistently removed from the system over time, P was initially stored in, but later released from, the reservoir. The subsequent release of legacy P from the reservoir led to higher outgoing, compared with incoming, P loads. Thus, reservoirs in intensively managed landscapes can act as sinks for N but sources for P over decadal timescales.
Anomalous Trapping of Low Pitch Angle Electrons by Coherent Whistler Mode Waves
Authors: Kitahara M. , Katoh Y.
Published: July 2019

Chorus emissions composed of coherent whistler mode waves are responsible for pitch angle scattering of energetic electrons. This scattering is closely related to energetic electron precipitation into the atmosphere, contributing to pulsating auroras. Conventionally, energetic electrons are considered to satisfy the cyclotron resonance condition over the energy range of a few to tens of kiloelectron volts and are scattered toward the loss cone by waves. However, previous simulation studies indicate that low pitch angle electrons tend to be scattered away from the loss cone by coherent whistler mode waves. We examine the mechanism of anomalous trapping at low pitch angles, deriving a particle equation with low pitch angle assumptions. An additional term that is conventionally neglected represents the Lorentz force caused by the wave magnetic field and the parallel particle velocity. Therefore, due to the large v‖×Bw Lorentz force, low pitch angle electrons satisfying the cyclotron resonant condition are scattered away from the loss cone and effectively trapped by waves. We perform test particle simulations in a one‐dimensional dipole magnetic field with a whistler mode wave model and reproduce the anomalous trapping of electrons. The simulation results show that the majority of electrons at high and moderate pitch angles are scattered toward low pitch angle regions while low pitch angle electrons are strongly scattered toward high pitch angle regions. Consequently, a coherent chorus element produces a bump in the electron pitch angle distribution.
Separation and Quantification of Ionospheric Convection Sources: 2. The Dipole Tilt Angle Influence on Reverse Convection Cells During Northward IMF
Authors: Reistad J. P. , Laundal K. M. , Østgaard N. , Ohma A. , Thomas E. G. , Haaland S. , Oksavik K. , Milan S. E.
Published: July 2019

This paper investigates the influence of Earth's dipole tilt angle on the reverse convection cells (sometimes referred to as lobe cells) in the Northern Hemisphere ionosphere during northward IMF, which we relate to high‐latitude reconnection. Super Dual Auroral Radar Network plasma drift observations in 2010–2016 are used to quantify the ionospheric convection. A novel technique based on Spherical Elementary Convection Systems (SECS) that was presented in our companion paper (Reistad et al., 2019, https://doi.org/10.1029/2019JA026634) is used to isolate and quantify the reverse convection cells. We find that the dipole tilt angle has a linear influence on the reverse cell potential. In the Northern Hemisphere the reverse cell potential is typically two times higher in summer than in winter. This change is interpreted as the change in interplanetary magnetic field‐lobe reconnection rate due to the orientation of the dipole tilt. Hence, the dipole tilt influence on reverse ionospheric convection can be a significant modification of the more known influence from vswBz. These results could be adopted by the scientific community as key input parameters for lobe reconnection coupling functions.
On the Contribution of Dipolarizing Flux Bundles to the Substorm Current Wedge and to Flux and Energy Transport
Authors: Birn J. , Liu J. , Runov A. , Kepko L. , Angelopoulos V.
Published: July 2019

Bursty bulk flows and dipolarizing flux bundles within them play an important role in the transport of mass, energy, and magnetic flux in the magnetotail. On the basis of an magnetohydrodynamic simulation of magnetotail reconnection and dipolarization, we investigate the contribution of individual bursts and flux transport events to the buildup of the substorm current wedge, as well as to the earthward transport of magnetic flux and energy. Individual events, defined by increased flow speed (flow bursts), increased cross‐tail electric field, or increased (or increasing) magnetic field Bz, are found to be closely related but not identical. Multiple individual magnetic flux transport events collectively contribute to tailward and azimuthal expansion of dipolarization in the inner tail and to an increase of total field‐aligned currents toward or away from the ionosphere. In contrast, the current closure across midnight, estimated from the surface currents at the inner (earthward) boundary of the simulation box, was found to remain only a fraction (∼10% or 0.2 MA) of the total Region 1 current into to ionosphere. The simulation showed dipolarization everywhere earthward of the near‐Earth x‐line, amounting to ∼2.3 ×108 Wb, commensurate with substorm estimates. This can appear at a satellite in various ways, through either classical earthward transport and pileup (outward moving accumulation) or lateral (azimuthal) or tailward (vortical or recoiled) convective motion of dipolarized flux tubes, or a combination of these.
Pressure Gradients Driving Ion Transport in the Topside Martian Atmosphere
Authors: Hamil O. , Cravens T. E. , Rahmati A. , Connerney J. E. P. , Andersson L.
Published: July 2019

Magnetic and thermal pressure gradient forces drive plasma flow in the topside ionosphere of Mars. Some of this flow can contribute to ion loss from the planet and thus affect atmospheric evolution. MAVEN measurements of the magnetic field, electron density, and electron temperature, taken over a 3‐year time period, are used to obtain averaged magnetic and thermal pressures in the topside ionosphere versus altitude, solar zenith angle, and latitude. Magnetic pressures are several times greater than thermal pressures for altitudes greater than about 300 km; that is, the plasma beta is less than one. The total pressure increases with altitude in the ionosphere and decreases with increasing solar zenith angle. Using these pressure patterns in the dayside ionosphere to estimate the pressure gradient force in the fluid momentum equation, we estimate horizontal day‐to‐night plasma flow speeds of a few kilometers per second near 400 km.
On the Momentum Transfer From Polar to Equatorial Ionosphere
Authors: Tu Jiannan , Song Paul
Published: July 2019

During space weather events, a large amount of energy and momentum from the solar wind inputs into the ionosphere‐thermosphere. A critical question is that if the solar wind‐magnetosphere interaction drives only the open field region in the polar caps, how the solar wind energy and momentum are transmitted to the low latitude and equatorial ionosphere. This important issue has been studied over decades and is still poorly understood, impeding space weather forecasting ability. Here we use our newly developed 2.5‐D ionosphere‐thermosphere simulation model that self‐consistently solves the density, velocity, and temperature for electrons, multiple ion and neutral species, and electromagnetic fields to study this challenging problem. The focus of the present study is on the prompt response of the ionosphere to a convection disturbance from the polar magnetosphere. The longer time scale responses caused by the neutral winds from the polar caps will be the topic of future studies. We show that the momentum is transferred from polar to equatorial ionosphere predominately by fast magnetosonic waves, and propagation of perturbations from the source region experiences delay, damping, and substantial reflection, and the ionosphere/thermosphere behaves like a low‐band‐pass filter. The finding from this study sheds new insight onto coupling processes within the magnetosphere‐ionosphere system.
Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration
Authors: Park Junghyun , Jun Eun Kyoung , Son Daryeon , Hong Wonjun , Jang Jihoon , Yun Wonjin , Yoon Byung Sun , Song Gwonhwa , Kim In Yong , You Seungkwon
Published: July 2019

Alopecia, one of the most common chronic diseases, can seriously affect a patient’s psychosocial life. Dermal papilla (DP) cells serve as essential signaling centers in the regulation of hair growth and regeneration and are associated with crosstalk between autocrine/paracrine factors and the surrounding environment. We previously demonstrated that amniotic fluid–derived mesenchymal stem cell–conditioned medium (AF-MSC-CM) accelerates hair regeneration and growth. The present study describes the effects of overexpression of a reprogramming factor, Nanog, on MSC properties, the paracrine effects on DP cells, and in vivo hair regrowth. First, we examined the in vitro proliferation and lifespan of AF-MSCs overexpressing reprogramming factors, including Oct4, Nanog, and Lin28, alone or in combination. Among these factors, Nanog was identified as a key factor in maintaining the self-renewal capability of AF-MSCs by delaying cellular senescence, increasing the endogenous expression of Oct4 and Sox2, and preserving stemness. Next, we evaluated the paracrine effects of AF-MSCs overexpressing Nanog (AF-N-MSCs) by monitoring secretory molecules related to hair regeneration and growth (IGF, PDGF, bFGF, and Wnt7a) and proliferation of DP cells. In vivo studies revealed that CM derived from AF-N-MSCs (AF-N-CM) accelerated the telogen-to-anagen transition in hair follicles (HFs) and increased HF density. The expression of DP and HF stem cell markers and genes related to hair induction were higher in AF-N-CM than in CM from AF-MSCs (AF-CM). This study suggests that the secretome from autologous MSCs overexpressing Nanog could be an excellent candidate as a powerful anagen inducer and hair growth stimulator for the treatment of alopecia.
Reduced P53 levels ameliorate neuromuscular junction loss without affecting motor neuron pathology in a mouse model of spinal muscular atrophy
Authors: Courtney Natalie L. , Mole Alannah J. , Thomson Alison K. , Murray Lyndsay M.
Published: July 2019

Spinal Muscular Atrophy (SMA) is a childhood motor neuron disease caused by mutations or deletions within the SMN1 gene. At endstages of disease there is profound loss of motor neurons, loss of axons within ventral roots and defects at the neuromuscular junctions (NMJ), as evidenced by pathological features such as pre-synaptic loss and swelling and post-synaptic shrinkage. Although these motor unit defects have been widely described, the time course and interdependancy of these aspects of motor unit degeneration are unclear. Recent reports have also revealed an early upregulation of transcripts associated with the P53 signalling pathway. The relationship between the upregulation of these transcripts and pathology within the motor unit is also unclear. In this study, we exploit the prolonged disease timecourse and defined pre-symptomatic period in the Smn2B/− mouse model to perform a temporal analysis of the different elements of motor unit pathology. We demonstrate that NMJ loss occurs prior to cell body loss, and coincides with the onset of symptoms. The onset of NMJ pathology also coincides with an increase in P53-related transcripts at the cell body. Finally, using a tamoxifen inducible P53 knockout, we demonstrate that post-natal reduction in P53 levels can reduce NMJ loss, but does not affect other aspects of NMJ pathology, motor neuron loss or the phenotype of the Smn2B/− mouse model. Together this work provides a detailed temporal description of pathology within motor units of an SMA mouse model, and demonstrates that NMJ loss is a P53-dependant process. This work supports the role for P53 as an effector of synaptic and axonal degeneration in a die-back neuropathy.
Poly (rC) binding protein 2 interacts with VP0 and increases the replication of the foot-and-mouth disease virus
Authors: Li Dan , Zhang Jing , Yang Wenping , He Yanchun , Ru Yi , Fu Shaozu , Li Lulu , Liu Xiangtao , Zheng Haixue
Published: July 2019

Foot-and-mouth disease virus (FMDV) causes a highly contagious and debilitating disease in cloven-hoofed animals, which leads to devastating economic consequences. Previous studies have reported that some FMDV proteins can interact with host proteins to affect FMDV replication. However, the influence of the interactions between FMDV VP0 protein and its partners on FMDV replication remains unknown. In this study, we found that the overexpression of poly (rC) binding protein 2 (PCBP2) promoted FMDV replication, whereas the knockdown of PCBP2 suppressed FMDV replication. Furthermore, PCBP2 can interact with FMDV VP0 protein to promote the degradation of VISA via the apoptotic pathway. Further studies demonstrated that FMDV VP0 protein enhanced the formation of the PCBP2-VISA complex. Ultimately, we found that the degradation of VISA was weaker in PCBP2-knockdown and FMDV VP0-overexpressing cells, or FMDV VP0-knockdown cells than in the control cells. Summarily, our data revealed that the interaction between PCBP2 and VP0 could promote FMDV replication via the apoptotic pathway.
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
Authors: Gracia Mélanie , Theis Sophie , Proag Amsha , Gay Guillaume , Benassayag Corinne , Suzanne Magali
Published: July 2019

Epithelial−mesenchymal transition (EMT) is an essential process both in physiological and pathological contexts. Intriguingly, EMT is often associated with tissue invagination during development; however, the impact of EMT on tissue remodeling remain unexplored. Here, we show that at the initiation of the EMT process, cells produce an apico-basal force, orthogonal to the surface of the epithelium, that constitutes an important driving force for tissue invagination in Drosophila. When EMT is ectopically induced, cells starting their delamination generate an orthogonal force and induce ectopic folding. Similarly, during mesoderm invagination, cells undergoing EMT generate an apico-basal force through the formation of apico-basal structures of myosin II. Using both laser microdissection and in silico physical modelling, we show that mesoderm invagination does not proceed if apico-basal forces are impaired, indicating that they constitute driving forces in the folding process. Altogether, these data reveal the mechanical impact of EMT on morphogenesis.