bluuebunny/crossref_metadata_2025 huggingface dataset:
TECNOLOGIAS ASSISTIVAS E FORMAÇÃO DOCENTE: O CASO DE ESCOLAS DE UMA REDE PÚBLICA FEDERAL DE ENSINO
Authors: Lima Letícia Aparecida Alves de , Pagnoncelli Vanessa , Silva Marcus Vinicius Gonçalves da
Published: August 2020

The approximation between knowledge and practice in Assistive Technologies (TA) in Brazilian schools is recent. Particularly, in the context of public schools, the application of TA in an inclusive education perspective is a new theme for the members of the Multifunctional Resource Rooms (SRMF), however, it is observed that there are policies and guidelines for AT to be implemented. In this context, the objective of this article is to analyze the perception of professionals working in the SRMF of schools in a federal public education network, belonging to the Colégio Militar do Brasil System, regarding the relevance of the use of TA and the continuing training of teachers in the area of inclusive education. Methodologically, the study has a qualitative and descriptive approach, and the collection of data obtained through a questionnaire prepared in Google Forms®, based on the classification of TA, by Sartoretto and Bersch (2018). The results show that the professionals who work in the SRMF of the schools surveyed have not yet appropriated the TA in an efficient way, as there is an underuse of these technologies due to the low number of trained teachers.
AS CONTRIBUIÇÕES DA EDUCAÇÃO A DISTÂNCIA PARA O DESENVOLVIMENTO LOCAL E REGIONAL: VISÃO DOS PROFISSIONAIS ATUANTES NOS POLOS DE APOIO PRESENCIAL
Authors: Gama Eloiza Ribeiro Lopes , Santos Marcelo Henrique Pereira dos , Duarte Francisco Ricardo , Rodrigues Luzia Coelho
Published: August 2020

This article aims to identify the Distance Education contributions as policy of expansion and democratization of higher education, under the focus of the view of Coordinators of Presential Support and Tutors and observe the contributions of the expansion of distance education courses for regional and local development in the states of Bahia and Pernambuco. To carry out this investigation, were selected four poles, located in the cities of Juazeiro / BA, Pintadas / BA, Ouricuri /PE and Trindade /PE. To collect data, we used the qualitative approach analysis. For the data collection process, it proceeded to the interviews with Pole Coordinators and Presential and Distant Tutors in the selected poles. In addition to these interviews, we used the survey of documentation and files (documents, spreadsheets and printed and digital records) of the Secretary of Distance Education of UNIVASF, in order to verify the locations and poles of graduates and locate Coordinators and Tutors. After this phase of collection, proceeded to the transcription of the interviews and document comparison, followed by analysis of collected data. Among the results, it highlights that the coordinators agreed that Distance Education has come to increase access to higher education and improving the lives of people. it stands out that still occur common difficulties revealed by them, among which the internet lack of quality and lack of support about the Pole maintenance with city managers. These results demonstrate the effective contribution of Distance Education, both in the training of graduates and for the local and regional development and show that this is a field still open to further investigations.
Advancing biodiesel production from microalgae Spirulina sp. by a simultaneous extraction–transesterification process using palm oil as a co-solvent of methanol
Authors: Pradana Yano Surya , Dewi Resti Nurmala , Di Livia Kanadya , Arisa Farida ,   Rochmadi, Cahyono Rochim Bakti , Budiman Arief
Published: August 2020

Microalgae have been considered as a potential candidate for biodiesel feedstock. Single-stage simultaneous extraction–transesterification process is proposed for simpler and more effective biodiesel conversion. In this study, the experiment of biodiesel production from microalgae Spirulina sp. was performed in a batch-stirred reactor using palm oil as a co-solvent of methanol and catalyzed by potassium hydroxide at a percentage of 1 wt% (w/w of palm oil). The effects of methanol–palm oil molar ratio, palm oil–microalgae weight ratio, and temperature on biodiesel yield were investigated. The results showed that the best biodiesel yield was 85.28% (99.01% of partial biodiesel yield from palm oil and 16.69% of partial biodiesel yield from dry microalgae), obtained at a methanol–palm oil molar ratio of 10:1, a palm oil–microalgae weight ratio of 5:1, and at a temperature of 60°C. Upon comparison, the overall yield increased by 34.59% (37.73% of partial biodiesel yield from palm oil and 13.00% of partial biodiesel yield from dry microalgae) than that of the two-stage (conventional) method. Single-stage simultaneous extraction–transesterification process also reduced the number of unsaturated fatty acid components in biodiesel that will lower the biodiesel quality.
Treatment of Parkinson’s disease using focused ultrasound with GDNF retrovirus-loaded microbubbles to open the blood–brain barrier
Authors: Wang Feng , Li Nana , Hou Ruanling , Wang Lu , Zhang Libin , Li Chenzhang , Zhang Yu , Yin Yaling , Chang Liansheng , Cheng Yuan , Wang Yongling , Lu Jianping
Published: August 2020

This study aims to prepare ultrasound-targeted glial cell-derived neurotrophic factor (GDNF) retrovirus-loaded microbubbles (M pLXSN-GDNF) to verify the properties of the microbubbles and to study the therapeutic effect of the GDNF retrovirus-loaded microbubbles combined with ultrasound (U) to open the blood–brain barrier (BBB) in a Parkinson’s disease (PD) model in rats, allowing the retrovirus to pass through the BBB and transfect neurons in the substantia nigra of the midbrain, thereby increasing the expression of GDNF. The results of western blot analysis revealed significant differences between U + MpLXSN-EGFP, U + M + pLXSN-GDNF, and M pLXSN-GDNF (P < 0.05) groups. After 8 weeks of treatment, the evaluation of the effect of increased GDNF expression on behavioral deficits in PD model rats was conducted. The rotation symptom was significantly improved in the U + MpLXSN-GDNF group, and the difference before and after treatment was significant (P < 0.05). Also, the content of dopamine and the number of tyrosine hydroxylase-positive (dopaminergic) neurons were found to be higher in the brain of PD rats in the U + M pLXSN-GDNF group than in the control groups. Ultrasound combined with GDNF retrovirus-loaded microbubbles can enhance the transfection efficiency of neurons in vivo and highly express the exogenous GDNF gene to play a therapeutic role in PD model rats.
nivel de aptitud cardiorrespiratoria y musculoesquelética presentan relación moderada significativa con la tensión arterial, composición corporal y glucemia en adolescentes mexicanos
Authors: Gómez-Gómez Eduardo , Arahujo-Beltrán Héctor David , Muñiz-Ramírez Luis Fernando , Pérez-Huitimea Ana Lilia , Andrade-Sánchez Adriana Isabel , Monroy-Llamas Alma Osiria
Published: August 2020

La aptitud cardiorrespiratoria (ACR) y la aptitud musculoesquelética (AME), según reportes, presentan deterioro entre la población adolescente a consecuencia del sedentarismo. Este estudio buscó establecer la relación del nivel de ACR y AME con los indicadores de salud adiposidad corporal, glucemia (Glu) y tensión arterial sistémica: sistólica (TAS) y diastólica (TAD); en adolescentes de 15 a 18 años. Participaron 44 hombres y 60 mujeres, estudiantes de bachillerato de Colima, México, con una edad de 17.1 ± 1.2 años. Mediante protocolo Tecumseh se evaluó la ACR y la AME con dinamometría, valorando la máxima tensión isométrica voluntaria en tres ejercicios: extensión de rodilla, extensión y flexión de codo, ajustados al área de corte transversal muscular. La TAS y TAD se determinó mediante tensiómetros de muñeca y se clasificó conforme a los rangos establecidos en la norma oficial mexicana NOM-030-SSA2-1999. El valor de Glu se obtuvo en muestra de sangre capilar colectada en tira reactiva determinación en glucómetro portátil, dos horas posteriores a la ingesta del medio día. El resultado se calificó conforme a la norma oficial mexicana NOM-015-SSA2-1994. Los análisis de regresión y estimación curvilínea indicaron que el nivel de ACR y AME presentan asociación a valores favorables a la salud en adiposidad corporal y masa muscular; en hombres, mayor desarrollo de la ACR y AME menores valores de tensión arterial sistémica.
Is the Rear Foot Elevated Split Squat Unilateral? An Investigation Into the Kinetic and Kinematic Demands
Authors: Helme Mark , Emmonds Stacey , Low Chris
Published: August 2020

Helme, M, Emmonds, S, and Low, C. Is the rear foot elevated split squat unilateral? An investigation into the kinetic and kinematic demands. J Strength Cond Res 36(7): 1781–1787, 2022—The purpose of the study was to determine the unilateral nature of the rear foot elevated split squat (RFESS). Specifically, the production of force by the rear leg was examined to better understand its role, if any, toward successful completion of the exercise. Male volunteers were recruited (n = 26, age = 23.8 ± 4.6 years, body mass = 88.1 ± 10.7 kg, and height = 1.79 ± 0.1 m), who were recreationally trained and engaged in a structured strength and conditioning program, including both bilateral and unilateral exercises, and had at least 2 years supervised training experience. Subjects participated in an incremental 5 repetition maximum protocol after familiarization. Kinetic data were recorded through 2 independent force plates, 1 integral to the floor and the second mounted on top of solid weightlifting blocks. Kinematic data were captured through 3-dimensional motion analysis. A total of 715 repetitions were analyzed, and the mean contribution of the lead foot to total vertical force production was 84.36 ± 3.6%. An almost certainly small positive correlation (rho = 0.25, confidence interval [CI] 0.18–0.33) was found between the percentage of force produced by the lead foot, with increasing exercise intensity. A most likely trivial, nonsignificant correlation (rho = −0.01, CI −0.09 to 0.06) with rear foot force production, representing the mass of the rear leg. Data from this study do not indicate that the rear foot contributes to the kinetic demands of the exercise and therefore suggests that the RFESS is a valid unilateral exercise.
Response of Muscle Damage Markers to an Accentuated Eccentric Training Protocol: Do Serum and Saliva Measurements Agree?
Authors: González-Hernández Jorge M. , Jiménez-Reyes Pedro , Cerón José J. , Tvarijonaviciute Asta , Llorente-Canterano Francisco J. , Martínez-Aranda Luis M. , García-Ramos Amador
Published: August 2020

González-Hernández, JM, Jiménez-Reyes, P, Cerón, JJ, Tvarijonaviciute, A, Llorente-Canterano, FJ, Martínez-Aranda, LM, and García-Ramos, A. Response of muscle damage markers to an accentuated eccentric training protocol: do serum and saliva measurements agree? J Strength Cond Res 36(8): 2132–2138, 2022—This study aimed (a) to examine the acute and delayed responses of 3 muscle damage biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) to an accentuated eccentric training protocol in serum, and (b) to explore the changes of these biomarkers in saliva and compare them with serum. Sixteen resistance-trained university students (10 men [age = 26.6 ± 4.8 years, full squat one repetition maximum [1RM] = 103.4 ± 14.4 kg] and 6 women [age = 22.7 ± 1.4 years, full squat estimated 1RM = 68.3 ± 10.5 kg]) completed an accentuated eccentric strength training protocol with the full squat exercise consisting of 8 sets of 10 repetitions against the 120% estimated 1RM load with 5 minutes of interset rest. The activity of muscle damage biomarkers (CK, AST, and LDH) was measured in serum and saliva before training (Pre), 24 hours after training (Post24), and 96 hours after training (Post96). In serum, lower values of the 3 muscle damage markers were observed at Pre compared to Post24 and Post96, whereas no significant differences were observed between Post24 and Post96 for any analyte. In saliva, there was a significant increase in men at Post96 compared with Pre in CK. The correlations between the measurements in serum and saliva ranged from trivial to small (r = −0.034 to 0.212). These results suggest that the measurement of muscle damage markers in serum and saliva do not provide the same information in the conditions of our study.
Optimization of Pig Positioning Method Based on Uniaxial Magnetoresistive Sensor
Authors: Xu Wei , Wei Minghui , Zhao Dandan , Zhang Peng , Liu Zhongxiang
Published: August 2020

Uniaxial magnetoresistive sensors based on the HMC1001 can realize acquisition, processing, and display of magnetic signals, with measurement error controlled to within 1 %, basically satisfying application requirements for positioning of the pig labeled with magnets. Given that the HMC1001 sensor has only one sensitive axis, to ensure real-time detection of the maximum magnetic fluctuation when the pig passes, according to the one-dimensional coordinate classical positioning method for uniaxial magnetic sensors, the horizontal east–west direction pipeline is first modeled, and the magnetic fluctuations in the horizontal and vertical directions are calculated. The results show that fluctuations in the vertical direction were slightly larger than those in the horizontal. For other angles between horizontal and vertical, the angle variable is introduced, and the comparison reveals that the magnetic fluctuation curve smoothly transitions from horizontal to vertical. The optimal detection attitude of the pipeline in any direction is then simulated by using the same method, revealing that the vertical magnetic value is the largest. Finally, related equivalent experiments are conducted, and the experimental curves are basically consistent with the simulations. Therefore, it can be concluded that the HMC1001 sensor should be installed perpendicular to the pipeline for optimal detection when positioning the pig.
Analysis of uranium ore concentrates for origin assessment
Authors: Varga Zsolt , Wallenius Maria , Mayer K. , Meppen M.
Published: August 2020

In this study the most important analytical methodologies are presented for the nuclear forensic investigation of uranium ore concentrates (yellow cakes). These methodologies allow to measure characteristic parameters which may be source material or process inherited. By the combination of the various techniques (e.g. infrared spectrometry, impurity content, rare-earth pattern and U, Sr and Pb isotope ratio analysis by mass spectrometry), the possible provenances of the illicit material can be narrowed down to a few options and its declared origin can be verified. The methodologies serve for nuclear forensic investigations as well as for nuclear safeguards, checking the consistency of information.
Dosimetry of cosmic radiation in the troposphere based on the measurements at the summit of Mt. Fuji
Authors: Yasuda H. , Yajima K. , Yoshida S.
Published: August 2020

Dose rate of cosmic-ray origin neutrons (abbreviated to “cosmic neutrons”) at aviation altitude was estimated based on the measurements at Mt. Fuji. Cosmic neutrons were measured in a facility of the Mt. Fuji Weather Station located at the summit of Mt. Fuji, the highest mountain in Japan (3776 m in altitude), in the summer of 2008 and 2009. The average of 1 cm ambient dose equivalent H*(10) for two measurements was verified by numerical model simulation and then used to empirically estimate the solar force field potential (FFP). The H*(10) rates at aviation altitude estimated from the measurements at Mt. Fuji were compared to those obtained in in-flight measurements onboard a civilian aircraft flying near Mt. Fuji at the time between the two measurements at the mountain. According to the results obtained, we expect that the empirical estimation based on the measurements at Mt. Fuji will work effectively for dosimetry of cosmic radiation in troposphere.
Precision measurements of the half-life of 196Au and 202Tl
Authors: Hirose K. , Kikunaga H. , Ohtsuki T.
Published: August 2020

The half-lives of 196Au and 202Tl have been precisely obtained by repeated measurements for 40 samples of 196Au and 16 samples of 202Tl using germanium detectors. The dead-time was corrected by the simultaneous detection of 662-keV γ rays from a reference source of 137Cs. The half-life value of 6.1451 ± 0.0013 (tot.) d, 0.35% shorter than the recommended value of ENSDF [1], has been obtained for 196Au. The error contains the statistical uncertainty and other random uncertainty. The half-life of 202Tl is determined to be 12.4706 ± 0.0055 (tot.) d with improved accuracy as compared to the latest measurement by a factor of 15.
Absorption spectra and cyclic voltammograms of uranium species in molten lithium molybdate–sodium molybdate eutectic at 550 ºC
Authors: Nagai T. , Uehara A. , Fukushima M. , Myochin M. , Fujii T. , Sato N. , Yamana H.
Published: August 2020

Absorption spectra of uranium species dissolved in molten lithium molybdate–sodium molybdate eutectic of 0.51Li2MoO4–0.49Na2MoO4 mixture at 550 ºC were measured by UV/Vis/NIR spectrophotometry, and their redox reactions were investigated by cyclic voltammetry. We found that the major ions of uranium species dissolved in the melt were uranyl penta-valent. After purging dry oxygen gas into the melt, penta-valent species were oxidized to the uranyl hexa-valent. In the cyclic voltammetry of the melt without uranium species, it was confirmed that the lithium-sodium molybdenum oxide compounds were deposited on the working electrode at the negative potential and the lithium molybdenum oxide compounds were deposited on the counter electrode at positive potential. When UO2 was dissolved into the melt, the reductive reaction of the uranium species was observed at the reductive potential of the pure melt. This suggests that the uranium species dissolved in the melts could be recovered as mixed uranium-molybdenum oxides by electrolysis.
Concentrations and activity ratios of 228Ra and 226Ra in surface seawater along the Pacific coast of Japan
Authors: Ohta T. , Mahara Y. , Kubota T. , Sato J. , Gamo T.
Published: August 2020

We measured the 228Ra/226Ra activity ratios in surface seawater along the Pacific coast of Japan at five ports around the island of Izu-Oshima (n = 29), at Atami in Sagami Bay (n = 13), and at Umizuri Park in Tokyo Bay (n = 14). We also conducted these measurements along a transect from the open Pacific Ocean across the Kuroshio to the mouth of Tokyo Bay (n = 7). The activity ratios decreased with increasing salinity of the sampling sites. The 228Ra/226Ra activity ratios in surface seawater along the coast gradually decreased after at the end of autumn and were lowest in winter and the beginning of spring. The surface salinity along the coast decreased from summer into autumn and increased from winter to the beginning of spring. The activity ratios decreased with the increase of salinity.

The variation in activity ratios at the three coastal sites is possibly caused by differing contributions of surface seawater from the Kuroshio and surrounding open ocean. The different patterns and ranges of variation in the 228Ra/226Ra activity ratios in surface seawater at Izu-Oshima, Atami, and Umizuri Park may reflect both the amount of water from the Kuroshio and vicinity, and the local bathymetry, because continental shelf sediment is the source of Ra isotopes in surface seawater.
Response of exposed bark and exposed lichen to an urban area
Authors: Cruz A. M. J. , Freitas M. C. , Verburg T. G. , Canha N. , Wolterbeek H. Th.
Published: August 2020

The aim of this study is to understand emission sources of chemical elements using biomonitoring as a tool. The selected lichen and bark were respectively Parmotrema bangii and Criptomeria japonica, sampled in the pollution-free atmosphere of Azores (Sao Miguel island), Portugal, which were exposed in the courtyards of 22 basic schools of Lisbon. The exposure was from January to May 2008 and from June to October 2008 (designated through the text as winter and summer respectively). The chemical element concentrations were determined by INAA. Conductivity of the lichen samples was measured. Factor analysis (MCTTFA) was applied to winter/summer bark/lichen exposed datasets. As emission sources, soil with anthropogenic contamination, a Se source, traffic, industry, and a sea contribution, were identified. In lichens, a physiological source based on the conductivity values was found. The spatial study showed contribution of sources to specific school positioning. Conductivity values were high in summer in locations as international Lisbon airport and downtown. Lisbon is spatially influenced by marine air mass transportation. It is concluded that one air sampler in Lisbon might be enough to define the emission sources under which they are influenced.
Detection limits of trace element analyses with the JAEA MPGA system
Authors: Murakami Y. , Oshima M. , Toh Y. , Kimura A. , Koizumi M. , Furutaka K. , Hatsukawa Y. , Kin T. , Hara K. Y. , Sushida K. , Taniguchi M. , Kojima N.
Published: August 2020

A multiple prompt gamma-ray analysis (MPGA) system was constructed at a cold neutron beam line of JRR-3 at Japan Atomic Energy Agency (JAEA). The system consists of 8 clover Ge detectors and BGO Compton suppressors. The detection limits for 41 trace elements with this system were determined. The MPGA system has low detection limits to elements such as B, Sc, Cd, Hg, Sm. We expect the MPGA system is a useful tool for analyses of toxic elements, heavy metals and rare-earth elements.
Electric field gradient at the 111Cd(←111In) site in Ga-doped ZnO
Authors: Sato W. , Ohkubo Y. , Itsuki Y. , Komatsuda S. , Minami D. , Kubota T. , Kawata S. , Yokoyama A. , Nakanishi T.
Published: August 2020

The time-differential perturbed angular correlation (TDPAC) method was applied to a study of the local environment at the 111Cd(←111In) probe nucleus introduced in 0.5 at. % Ga-doped ZnO. The TDPAC spectrum obtained at room temperature suggests that the doped Ga ions reside at the substitutional Zn site and they are locally associated in immediate proximity to the probe, reflecting strong attractive force between the probe and the dopants. The relative width of the magnitude of the electric field gradient produced at the probe nucleus shows that the doped Ga ion(s) adjacent to the probe is/are diversely distributed compared with doped In ion(s).
From Bio-waste to Bone Substitute
Authors: Ressler Antonia , Zadro Karla , Ivanković Hrvoje , Ivanković Marica , Cvetnić Matija , Antunović Maja , Gudelj Ana
Published: August 2020

Nanocomposite structure of the bone can be mimicked by chitosan/hydroxyapatite (CS/HAp) composite scaffold. Biological hydroxyapatite (HAp) contains various ions, which have a crucial role in bone growth. The aim of the present work was to synthesize biomimetic hydroxyapatite and prepare composite scaffolds based on chitosan, where HAp was synthesised from hen eggshells, seashells and cuttlefish bone. The powders were composed of nano-structured calcium deficient HAp and amorphous calcium phosphate (ACP). In the as-prepared powders, Sr2+, Mg2+ and Na+ ions were detected as a result of using biogenic precursor of Ca2+ ions. Highly porous CS/HAp structures have been prepared by freeze-gelation technique. The CS/HAp scaffolds have shown highly porous structure with very well interconnected pores and homogeneously dispersed HAp particles. The MTT assay of CS/HAp scaffolds has shown no toxicity, and the live/dead assay has confirmed good viability and proliferation of seeded cells.
Pubertal development and premature ovarian insufficiency in patients with APECED
Authors: Saari Viivi , Holopainen Elina , Mäkitie Outi , Laakso Saila
Published: August 2020

Objective:

To determine the natural course of pubertal development, growth during puberty, and development of POI in females with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also called autoimmune polyendocrine syndrome type I.

Design:

Longitudinal follow-up study.

Methods:

A national cohort of females with APECED aged ≥12 years were followed during 1965–2018. Attainment of adult height was defined when patients’ height increased less than 1 cm per year. Diagnosis of POI was based on delayed puberty or POI symptoms with amenorrhea, and/or FSH ≥40 IU/L.

Results:

Altogether 40 women with APECED were followed up to the average age of 37.3 (range: 14.6–61.9) years; 16 females (40%) were ≥ 40 years. Pubertal development started spontaneously in 34 patients and 29 had spontaneous menarche. POI developed in 28 patients (70%) at the median age of 16.0 years (range: 11.3–36.5), and in 20 of them (71%) before attaining adult height. In 11 cases puberty was induced or completed by hormonal therapy. Patients with POI were significantly shorter at menarche, but adult heights did not differ from non-POI females. Patients with POI had more often primary adrenocortical insufficiency (93% vs 58%, P = 0.017) and ovarian antibodies (81% vs 30%, P=0.003) compared to those with normal ovarian function (n = 12).

Conclusions:

POI developed in the majority of patients with APECED, often before or shortly after menarche. Timely commencement of hormonal replacement therapy is important to ensure optimal pubertal development and growth. The possibility of fertility preservation before development of POI in APECED patients should be further studied.
PREIMPLANTATION GENETIC TESTING: Single-cell technologies at the forefront of PGT and embryo research
Authors: Tšuiko Olga , Fernandez Gallardo Elia , Voet Thierry , Vermeesch Joris Robert
Published: August 2020

While chromosomal mosaicism in the embryo was observed already in the 1990s using both karyotyping and FISH technologies, the full extent of this phenomenon and the overall awareness of the consequences of chromosomal instability on embryo development has only come with the advent of sophisticated single-cell technologies. High-throughput techniques, such as DNA microarrays and massive parallel sequencing, have shifted single-cell genome research from evaluating a few loci at a time to the ability to perform comprehensive screening of all 24 chromosomes. The development of genome-wide single-cell haplotyping methods have also enabled for simultaneous detection of single-gene disorders and aneuploidy using a single universal protocol. Today, three decades later haplotyping-based embryo testing is performed worldwide to reliably detect virtually any Mendelian hereditary disease with a known cause, including autosomal-recessive, autosomal-dominant and X-linked disorders. At the same time, these single-cell assays have also provided unique insight into the complexity of embryo genome dynamics, by elucidating mechanistic origin, nature and developmental fate of embryonic aneuploidy. Understanding the impact of postzygotically acquired genomic aberrations on embryo development is essential to determine the still controversial diagnostic value of aneuploidy screening. For that reason, considerable efforts have been put into linking the genetic constitution of the embryo not only to its morphology and implantation potential, but more importantly to its transcriptome using single-cell RNA sequencing. Collectively, these breakthrough technologies have revolutionized single-cell research and clinical practice in assisted reproduction and led to unique discoveries in early embryogenesis.
De NovoAssembly of the Northern Cardinal (Cardinalis cardinalis) Genome Reveals Candidate Regulatory Regions for Sexually Dichromatic Red Plumage Coloration
Authors: Sin Simon Yung Wa , Lu Lily , Edwards Scott V
Published: August 2020

Northern cardinals (Cardinalis cardinalis) are common, mid-sized passerines widely distributed in North America. As an iconic species with strong sexual dichromatism, it has been the focus of extensive ecological and evolutionary research, yet genomic studies investigating the evolution of genotype–phenotype association of plumage coloration and dichromatism are lacking. Here we present a new, highly-contiguous assembly for C. cardinalis. We generated a 1.1 Gb assembly comprised of 4,762 scaffolds, with a scaffold N50 of 3.6 Mb, a contig N50 of 114.4 kb and a longest scaffold of 19.7 Mb. We identified 93.5% complete and single-copy orthologs from an Aves dataset using BUSCO, demonstrating high completeness of the genome assembly. We annotated the genomic region comprising the CYP2J19 gene, which plays a pivotal role in the red coloration in birds. Comparative analyses demonstrated non-exonic regions unique to the CYP2J19 gene in passerines and a long insertion upstream of the gene in C. cardinalis. Transcription factor binding motifs discovered in the unique insertion region in C. cardinalis suggest potential androgen-regulated mechanisms underlying sexual dichromatism. Pairwise Sequential Markovian Coalescent (PSMC) analysis of the genome reveals fluctuations in historic effective population size between 100,000–250,000 in the last 2 millions years, with declines concordant with the beginning of the Pleistocene epoch and Last Glacial Period. This draft genome of C. cardinalis provides an important resource for future studies of ecological, evolutionary, and functional genomics in cardinals and other birds.
Películas-voz: estéticas de no ficción decolonial en Barcelona
Authors: Gual Joan Miquel
Published: August 2020

La investigación decolonial estudia la configuración del mundo después del final de las colonias. Las diásporas globales, las relaciones norte-sur, la pervivencia de rastros coloniales en las antiguas metrópolis y colonias, la situación de dominio neocolonial impuesta por algunas multinacionales o las luchas de liberación contra este marco político son algunos de los temas recurrentes. De manera más importante para el texto que se presenta a continuación, esta rama de estudios también abarca la representación de los conflictos urbanos vinculados al sistema de fronteras. En el caso de Barcelona han aparecido un número significativo de títulos de no ficción caracterizados por algún tipo de alianza entre personas y colectivos locales y migrantes. Tales alianzas erigen una perspectiva crítica encarnada y situada que contribuye, desde el campo de la producción audiovisual, a la protesta en contra del racismo y el régimen de fronteras dentro de la propia ciudad. La función decolonial perseguida por los títulos de no ficción que se analizarán es la circulación de materiales, algunas veces de urgencia, que sirven para contraatacar los discursos hegemónicos criminalizadores y las múltiples invisibilizaciones de colectivos humanos racializados, fruto de fronteras que son herencia de un pasado colonial que en gran parte se mantiene vigente.
La complejidad de representar la vida en los límites a través de la obra documental de Yto Barrada
Authors: Santamaría Mesanza Zuriñe
Published: August 2020

La obra documental de Yto Barrada muestra la complejidad de la vida en los límites, de los migrantes que esperan el momento de cruzar y de los efectos de la frontera en la población local y en la propia ciudad. Y lo representa alejándose de cualquier cliché orientalista o exótico. Algunos teóricos han leído su obra como la representación de sujetos desubjetivizados. Sin embargo, basándonos en teorías de Ariella Azoulay, Judith Butler y Hannah Arendt, presentamos una lectura según la cual los sujetos y la propia ciudad de Tánger, en la obra de Yto Barrada, son visibilizados y representados como sujetos activos plenos de autonomía; y la memoria visual de la ciudad de Tánger y de la sociedad que la habita, es también recuperada y visibilizada.
Neologisms in Hungarian terms of quality assurance
Authors: Sólyom Réka
Published: August 2020

By employing a functional-cognitive frame, this paper, in which neologisms derived from English are analysed, focuses on the semantics of new Hungarian terms of quality assurance (quality management in general). Although the importance of unambiguous terms in scientific communication is often emphasised (Temmerman 2002: 211), it has been observed that the presence of conceptual metonymies and metaphors (Lakoff and Johnson 1980, Panther and Thornburg 2003, Kövecses 2015) also fosters understanding of technical languages. The author’s previous research in the field of the semantics of Hungarian neologisms (e.g. Sólyom 2014a, b, 2016) has also revealed that the presence of metonymies and metaphors has a significant impact upon the process of meaning construal. The present research assumes that various metonymic and metaphorical meanings occur in the semantics of novel Hungarian terms of quality assurance. To attest this, examples from a questionnaire filled by Hungarian quality engineers in 2018 will be analysed. Another question addressed in this paper is whether there is a mental reason for the fact that although there are colloquial Hungarian words and expressions for describing the processes of manufacturing, experts in the field do not use them, but rather employ neologisms with English roots. Indeed, this is how specialists distinguish technical terms from everyday expressions.
Treatment of Coronavirus Disease 2019: Shooting in the Dark
Authors: Tamargo Juan
Published: August 2020

The identification of effective interventions against the coronavirus disease 2019 (COVID-19) pandemic has become a health priority. The rational treatment of a disease is based on the knowledge of its pathophysiology, the identification of a therapeutic target and the confirmation of the efficacy and safety of the selected therapeutic intervention in randomised controlled trials. However, we are facing the COVID-19 pandemic without a clear understanding of the pathophysiology of the disease. As we are fighting against a viral infection, drugs previously developed or approved to treat other viral infections or that exhibit a broad-spectrum antiviral activity, anti-inflammatory drugs and drugs against cytokine storm are currently being tested. Unfortunately, the efficacy and safety of these medications remain uncertain, and some may increase the risk of cardiovascular complications in patients with COVID-19. Thus, at the present time, due to the lack of solid scientific data to support a therapeutic strategy, we truly are shooting in the dark with the treatment of COVID-19. We must wait for the results of ongoing randomised, controlled studies before the widespread adoption of these drugs. In the meantime, investigational anti-COVID-19 drugs should be used in hospitals or as part of clinical trials.
Desarrollo y validación de un método de cromatografía gaseosa para la determinación de mentol, salicilato de metilo, timol y ácido benzoico en solución antiséptica
Authors: Fonseca  Gola Antonio , Cordoví Velázquez Juan Manuel , Benítez Guerra Niurka , Fernández Cervera Mirna
Published: August 2020

Se desarrolló y validó un método por cromatografía gaseosa para la cuantificación simultánea de mentol (MT), salicilato de metilo (SM), timol (TM) y ácido benzoico (AB) en una solución antiséptica bucal. Se utilizó una columna DB-WAX y dietilenglicol como estándar interno. Se determinó la linealidad en un intervalo de concentraciones de 64,00 a 96,00 μg/mL (MT), 80,00 a 120,00 μg/mL (SM), 96,00 a 144,00 μg/mL (TM) y 48,00 a 72,00 μg/mL (AB), obteniendo coeficientes de correlación superiores a 0,999, y coeficientes de variación de los factores de respuestas de 1,18, 1,95, 3,52 y 1,48%, respectivamente. Se establecieron límites de detección de 0,51, 1,14, 3,34 y 1,402 ng/mL para el MT, SM, TM y AB, respectivamente, mientras los límites de cuantificación fueron de 1,45, 3,43, 9,73 y 4,36 ng/mL en cada caso. Los porcentajes de recuperación fueron de 100,03, 99,31, 99,92 y 100,12; con coeficientes de variación de 0,42%, 0,79%, 0,66% y 0,76% para cada caso. El método fue lineal, exacto, preciso y selectivo para la determinación de los analitos en el control de calidad.
Method to Obtain a Vector of Hyperparameters: Application in Bernoulli Trials
Authors: Torres Ome Llerzy Esneider , Tovar Cuevas Jose Rafael
Published: August 2020

The main diﬃculties when using the Bayesian approach are obtaining information from the specialist and obtaining hyperparameters values of the assumed probability distribution as representative of knowledge  external to the  data. In addition to the  fact  that  a large  part  of the  literature on this subject is characterized by considering prior conjugated distributions for the parameter of interest. An method is proposed  to ﬁnd the hyperparameters of a nonconjugated prior  distribution. The following  scenarios were considered for Bernoulli trials: four prior distributions (Beta, Kumaraswamy, Truncated Gamma   and   Truncated  Weibull) and four scenarios  for  the  generating process. Two necessary,  but not suﬃcient  conditions were  identiﬁed to ensure   the  existence of  a  vector of  values for  the  hyperparameter. The Truncated Weibull prior distribution performed the worst.  The methodology was  used  to estimate the  prevalence of two  transmitted sexually infections in an Colombian  indigenous community.
On Predictive Distribution of K-Inﬂated Poisson Models with and Without Additional Information
Authors: Sadeghkhani Abdolnasser , Ahmed S. Ejaz
Published: August 2020

This   paper   addresses  diﬀerent   approaches  in  ﬁnding   the   Bayesian predictive distribution of a random  variable from a Poisson  model that  can handle  count data  with an inﬂated  value  of K ∈ N, known as the KIP  model. We explore  how we can  use  other  source  of additional information to  ﬁnd such  an estimator. More speciﬁcally, we ﬁnd a Bayesian estimator of future density of random  variable Y1 , based  on observable X1  from the K1 IP(p1 , λ1 ) model, with and without assuming that  there exists  another random  variable X2 , from the K2 IP(p2 , λ2 ) model, independent of X1 , provided λ1  ≥ λ2 , and compare their  performance using  simulation method.
Respuesta agronómica y productiva de ocho variedades de arroz bajo condiciones de manejo agroecológico
Authors: Calero Hurtado Alexander , Pérez Díaz Yanery , González-Pardo Hurtado Yainier , Yanes Simón Lesly Analay , Olivera Viciedo Dilier , Peña Calzada Kolima , Pérez Rodríguez Anay
Published: August 2020

Los sistemas de arroz convencionales consumen grandes cantidades de agroquímicos y dan como resultado la contaminación de los agroecosistemas. Por lo tanto, deben desarrollarse sistemas de producción de arroz con ahorro de agroquímicos y alta eficiencia de uso de recursos. El objetivo del presente estudio fue evaluar el efecto agroproductivo de ocho variedades de arroz de ciclo medio en el aumento de la productividad del cultivo bajo condiciones de manejo agroecológico. La siembra de las variedades se realizó de forma manual, directa a voleo. Fueron evaluados los siguientes indicadores morfoproductivos, número de tallos fértiles por plantas, longitud de las plantas (cm), número de panículas por planta, número de granos por panículas, longitud de la panícula (cm), masa de 1000 semillas (g) y el rendimiento (t ha-1). Los resultados indicaron que las variedades de arroz IA-31 y ILP-5 presentaron el mejor desempeño agronómico y productivo. La agrupación de los cultivares mostró patrones de asociaciones entre los caracteres morfológicos y los cultivares. El estudio actual indicó que los rasgos fenológicos y productivos fueron útiles para la evaluación preliminar de las variedades y pueden usarse como un enfoque de amplio espectro para comparar la diversidad genética de los cultivares de arroz bajo condiciones agroecológicas.
Temperança de Tonus: agora vai ser assim contra a intolerância
Authors: Gomes Daniel de Oliveira
Published: August 2020

O presente artigo estuda a poesia de Leonardo Tonus. Este autor publicou recentemente seu livro “Agora vai ser assim” pela editora Nos (2018). Investigamos uma poesia que acusa a intolerância do presente a partir de um estilo bem mesclado e complexo. Procuramos uma relação com a figura da Temperança, do Tarot. Analisamos sua biografia, enquanto desterritorializado e, também, vários de seus versos. Recorremos, teoricamente, à geografia humana de Milton Santos; à sociologia da modernidade líquida de Zigmunt Bauman. Uma poesia altamente crítica que questiona a intolerância, o preconceito e a xenofobia dos tempos atuais.
Fake news e pós-verdade na construção do Neoconservadorismo no Brasil pós-2013 e os efeitos nas eleições de 2018
Authors: Azevedo Mauri de Castro , Lima Marcus Antônio Assis
Published: August 2020

A conjuntura política brasileira recente efetivou o recrudescimento do conservadorismo, especialmente no que diz respeito ao comportamento de uma parcela considerável da população que, ao abraçar ideias da extrema direita, contribuiu para levar o Brasil a uma situação obscurantista. Diante da relevância dessa temática na atualidade, este estudo tem por objetivo desenvolver uma discussão sobre o crescimento das ideias extremistas sob a influência das fake news na era da pós-verdade. Metodologicamente é conduzido pela abordagem qualitativa de caráter exploratório e descritivo, à luz dos preceitos teóricos encontrados em Marcondes Filho (1989), Tandoc, Lim e Ling (2017), Dunker (2017), Gomes (2018), Löwy (2015), Miguel (2018), Almeida (2018), Souza (2016) e Charaudeau (2016), e apresenta uma discussão sobre a intolerância política nas redes sociais virtuais durante as eleições presidenciais de 2018. Como resultado desse cenário e com base no referencial utilizado, verificamos que a extrema-direita utilizou o ódio como plataforma política para manipular a opinião pública. Com efeito, o País registrou uma reconfiguração do sentido da vida política nas instâncias de poder e cidadã.
(Diz)positivo para matar: uma análise sobre o discurso de ódio no Brasil contemporâneo
Authors: Amorim Marcelo Vinicius Costa , Fernandes Júnior Antônio
Published: August 2020

O presente artigo consiste em uma análise de enunciados, mobilizando o conceito de discurso pela perspectiva foucaultiana em conjunto com a releitura de Deleuze. Outrossim, buscamos um diálogo com as contribuições teóricas de Achille Mbembe e o conceito de necropolítica, para então endossar nossas discussões sobre os discursos de ódio e seus desdobramentos em nosso cotidiano. Por meio de uma seleção de publicações presente nas redes sociais, usamos o método arquegenealógico para possibilitar uma reflexão sobre questões concernentes à política e às relações humanas no cenário atual do Brasil. Operamos uma crítica a partir do discurso de ódio, que é vigente, merecendo, assim, devidas cautelas para se repensar os processos de subjetivação a ele correlatos.
Discursos de resistência à intolerância pela censura: o caso da propaganda do Banco do Brasil
Authors: Grigoletto Evandra , França Thiago Alves
Published: August 2020

O presente artigo se propõe a analisar a questão da intolerância pelo viés da censura, a partir da polêmica sobre uma peça publicitária do Banco do Brasil (BB) que teve sua exibição oficial impedida após avaliação negativa do presidente Jair Bolsonaro. Em nossas análises, a peça é retomada como condição de legibilidade e inteligibilidade dos discursos de resistência que circularam nas redes sociais dialogando com o veto da campanha do banco, e que são, também, nosso objeto de análise. Partindo da perspectiva teórico-metodológica da Análise do Discurso pecheuxtiana, observamos que o espaço virtual tem funcionado tanto como condição de produção do discurso intolerante, quanto como condição de produção de formas alternativas de resistência a esse discurso. As análises nos apontam para um funcionamento discursivo que coloca em jogo, de um lado, a intolerância pela censura e, de outro, as formas de resistência pela ironia.
Aquilo que não pode deixar de ser dito: o efeito de pré-construído do discurso machista
Authors: Tejada Bruna Vitória , Vinhas Luciana Iost
Published: August 2020

Este trabalho propõe-se a um gesto de interpretação assentado nos princípios teóricos da Análise de Discurso de tradição francesa. Com interesse particular na noção de pré-construído, elaborada por Paul Henry e desenvolvida por Michel Pêcheux, objetiva-se pesquisar como ele é reproduzido como um saber que todo mundo sabe, à revelia da formação discursiva com a qual o sujeito se identifica. Assim, o pré-construído é entendido como um saber universal; mesmo que o sujeito não se identifique com esse saber, ele pode invadir seu discurso. Atraídas pelas relações de gênero estabelecidas em nossa formação social, buscamos identificar irrupções do discurso hegemônico patriarcal sob a forma de pré-construídos em discursos tidos como subversivos. O corpus selecionado para análise é constituído por materialidades verbais e não verbais e foi coletado no site de rede social Facebook. Para a análise dos aspectos imagéticos, tem-se por base os estudos de Quevedo (2012), que vê na imagem efeitos similares aos do texto escrito.
Tonos intolerantes en discursos de grandes medios de comunicación brasileños: un estudio dialógico
Authors: Di Fanti Maria da Glória Corrêa , López-Muñoz Juan Manuel
Published: August 2020

Este artículo tiene como objetivo presentar un estudio dialógico de discursos con tonos intolerantes contra la presidenta Dilma Rousseff propagados por los grandes medios de comunicación brasileños en el momento del proceso de destitución. En concreto, se analizan enunciados verbo-visuales de la revista Isto É, del 06/04/2016, y del periódico Folha de S. Paulo, del 02/05/2016, observando las características de producción de tales discursos y la forma en que la destinataria se ve afectada por la intolerancia. Los resultados revelan que los tonos intolerantes, al mismo tiempo que se dirigen a una determinada víctima, presuponen un coro de apoyo que comparte unas mismas valoraciones y participa en la producción, recepción y circulación, fomentando la intolerancia y la polarización de la sociedad. Las reflexiones desarrolladas en el presente artículo destacan la importancia de la responsabilidad de los medios de comunicación de masas en el fomento del respeto por las diferencias, el compromiso activo crítico con los problemas sociales y el impulso del diálogo con el fin reorientar su coro de apoyo a la preservación de los valores democráticos, indispensables para enfrentar la crisis actual de intolerancia.
Discursos (In)tolerantes y Democracia Pluralista
Authors: López-Muñoz Juan Manuel , Di Fanti Maria da Glória Corrêa , Covatti Malcorra Bárbara Luzia
Published: August 2020

---
Politik Identitas dalam Pilkada DKI Jakarta Tahun 2017: Perspektif Pemikiran Politik Nurcholish Madjid
Authors: Fautanu Idzam , M Buhori , Gunawan Heri
Published: August 2020

Munculnya kasus penistaan agama, dan gerakan aksi damai 212 telah menjadi pembangkit semangat umat Islam untuk memilih pemimpin yang seagama disinyalir menjadi faktor utama penggerak terpilihnya Anies-Sandi sebagai Gubernur dan Wakil Gubernur DKI Jakarta dalam Pilkada tahun 2017. Fokus dan tujuan penelitian pada artikel ini adalah untuk melihat pemikiran–pemikiran politik Nurcholish Madjid dalam bangkitnya politik identitas pada Pilkada DKI 2017. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Adapun teknik pengumpulan datanya menggunakan observasi, wawancara mendalam dan teknik dokumentasi. Hasil penelitian menunjukkan bahwa politik identitas masyarakat Muslim DKI Jakarta dilandasi agama dan pada prinsipnya adalah suatu keniscayaan dalam budaya politik. Sementara corak politik identitas masyarakat Muslim DKI Jakarta dalam bentuk ukhuwah Islamiyah dan lebih kepada faktor budaya dan keagamaan. Diwujudkan dalam bentuk keaktifan dalam rangka mensukseskan kampanye, menggerakan masyarakat Muslim sebagai politik identitas dan mendukung kemenangan pasangan Anies-Sandi dalam Pilkada DKI Jakarta 2017.