bluuebunny/crossref_metadata_2025 huggingface dataset:
Phosphorylation of cysteine string protein-α up-regulates the frequency of cholinergic waves via starburst amacrine cells
Authors: Chen Ching-Feng , Wo Rita R. , Huang Chien-Ting , Cheng Tzu-Lin , Lu Juu-Chin , Wang Chih-Tien
Published: May 2022

During the first postnatal week in rodents, cholinergic retinal waves initiate in starburst amacrine cells (SACs), propagating to retinal ganglion cells (RGCs) and visual centers, essential for visual circuit refinement. By modulating exocytosis in SACs, dynamic changes in the protein kinase A (PKA) activity can regulate the spatiotemporal patterns of cholinergic waves. Previously, cysteine string protein-α (CSPα) is found to interact with the core exocytotic machinery by PKA-mediated phosphorylation at serine 10 (S10). However, whether PKA-mediated CSPα phosphorylation may regulate cholinergic waves via SACs remains unknown. Here, we examined how CSPα phosphorylation in SACs regulates cholinergic waves. First, we identified that CSPα1 is the major isoform in developing rat SACs and the inner plexiform layer during the first postnatal week. Using SAC-specific expression, we found that the CSPα1-PKA-phosphodeficient mutant (CSP-S10A) decreased wave frequency, but did not alter the wave spatial correlation compared to control, wild-type CSPα1 (CSP-WT), or two PKA-phosphomimetic mutants (CSP-S10D and CSP-S10E). These suggest that CSPα-S10 phosphodeficiency in SACs dampens the frequency of cholinergic waves. Moreover, the level of phospho-PKA substrates was significantly reduced in SACs overexpressing CSP-S10A compared to control or CSP-WT, suggesting that the dampened wave frequency is correlated with the decreased PKA activity. Further, compared to control or CSP-WT, CSP-S10A in SACs reduced the periodicity of wave-associated postsynaptic currents (PSCs) in neighboring RGCs, suggesting that these RGCs received the weakened synaptic inputs from SACs overexpressing CSP-S10A. Finally, CSP-S10A in SACs decreased the PSC amplitude and the slope to peak PSC compared to control or CSP-WT, suggesting that CSPα-S10 phosphodeficiency may dampen the speed of the SAC-RGC transmission. Thus, via PKA-mediated phosphorylation, CSPα in SACs may facilitate the SAC-RGC transmission, contributing to the robust frequency of cholinergic waves.
Public pensions and low-income dynamics in Canada
Authors: El-Attar Mayssun , Fonseca Raquel
Published: May 2022

This paper focuses on individuals over 50 and shows that considering persistence and low-income dynamics is essential for understanding poverty. We use administrative data for Canada from the Longitudinal and International Study of Adults. The paper shows that poverty for seniors is highly persistent and strongly depends on lifetime earnings. We show that beginning to receive a public pension implies a higher probability of exit from poverty. Public pensions thereby help to explain the lower overall incidence of poverty among the elderly. These results are confirmed in a dynamic probit model, which allows controlling for individuals' unobserved heterogeneity and state dependence. While public pensions do not eliminate poverty among older adults, they help to alleviate it by reducing persistence and increasing exit for those who are most at risk.
Opioid withdrawal syndrome developing after long-term administration of naldemedine
Authors: Ishida Mayumi , Uchida Nozomu , Yabuno Akira , Hasegawa Kosei , Mizunuma Naoki , Takahashi Takao , Onishi Hideki
Published: May 2022

Objective

One of the side effects of opioid administration is opioid-induced constipation (OIC). To address this side effect, the oral peripheral μ opioid receptor antagonist naldemedine was developed. As this drug does not cross the blood–brain barrier, it is thought that it does not lead to opioid withdrawal syndrome (OWS) with central nervous system symptoms.

Methods

Here, we report a cancer patient who presented with symptoms centered round anxiety and irritation 4 months after administration of naldemedine for OIC and who was diagnosed with OWS after close investigation.

Results

The patient was a 65-year-old female who had surgery for stage IB endometrial cancer 4 years previously, but experienced recurrence involving the pelvis 2 years later. Medical narcotics were used to control pain, but naldemedine was started to control subsequent constipation. When naldemedine-related OWS was suspected and the administration of naldemedine discontinued, the above symptoms disappeared within two days, and no recurrence was observed thereafter.

Significance of the results

For patients receiving naldemedine, it is necessary to consider the possibility of OWS regardless of the period of administration in order to maintain patient quality of life.
Eye movement desensitization and reprocessing (EMDR) and mediative behavioral therapy for the treatment of suffocation related post-traumatic stress disorder (PTSD) in amyotrophic lateral sclerosis (ALS): A case report
Authors: Oudman Erik , Baert Jill C.M.
Published: May 2022

Objective

Eye movement desensitization and reprocessing (EMDR) is an established treatment for post-traumatic stress disorders (PTSD). Some patients diagnosed with amyotrophic lateral sclerosis (ALS) experience PTSD following choking or suffocation in the course of progressive loss of the ability to breathe. Although a loss of breathing functions in ALS is relatively common, there are currently no studies available on treatment for the fear of choking following advanced ALS.

Methods

In this case study, we describe the positive effects of EMDR, an evidence-based form of trauma therapy, in a 48-year-old female, suffering from advanced ALS. As the consequence of ALS, she was not able to speak or breath independently, but could communicate through a speech-generating device. She experienced panic attacks, flashbacks, nightmares, and severe anxiety after her tracheostomy jammed, and she almost suffocated.

Results

Mediative treatment was started by instructing the care staff to respond neutrally with step-by-step instructions following tracheostomy jam, resulting in significantly less panic attacks and flashbacks. EMDR was initiated two weeks later, and resulted in full remittance of the trauma symptomatology.

Significance of the results

The present case study suggests that symptoms of PTSD, namely the strong fear of suffocation, can be successfully treated by means of mediative behavioral therapy combined with EMDR.
Ocean Ventilation Controls the Contrasting Anthropogenic CO2 Uptake Rates Between the Western and Eastern South Atlantic Ocean Basins
Authors: Gao Hui , Cai Wei‐Jun , Jin Meibing , Dong Changming , Timmerman Amanda H. V.
Published: May 2022

The South Atlantic Ocean is an important region for anthropogenic CO2 (Canth) uptake and storage in the world ocean, yet is less studied. Here, after an extensive sensitivity test and method comparison, we applied an extended multiple linear regression method with six characteristic water masses to estimate Canth change or increase (ΔCanth) between 1980s and 2010s in the South Atlantic Ocean using two meridional transects (A16S and A13.5) and one zonal transect (A10). Over a period of about 25 years, the basin‐wide ΔCanth was 3.86 ± 0.14 Pg C decade−1. The two basins flanking the Mid‐Atlantic Ridge had different meridional patterns of ΔCanth, yielding an average depth‐integrated ΔCanth in the top 2000 m of 0.91 ± 0.25 mol m−2 yr−1 along A16S on the west and 0.57 ± 0.22 mol m−2 yr−1 along A13.5 on the east. The west‐east basin ΔCanth contrasts were most prominent in the tropical region (0–20°S) in the Surface Water (SW), approximately from equator to 35°S in the Subantarctic Mode Water (Subantarctic Mode Water (SAMW)), and all latitudes in the Antarctic Intermediate Water (AAIW). Less ΔCanth in the eastern basin than the western basin was caused by weaker ventilation driven by SAMW and AAIW formation and subduction and stronger Antarctic Bottom Water (AABW) formation in the former than the latter. In addition to the spatial heterogeneity, Canth increase rates accelerated from the 1990s to the 2000s, consistent with the overall increase in air‐sea CO2 exchange in the South Atlantic Ocean.
Magnetic Signatures of the 15 January 2022 Hunga Tonga–Hunga Ha'apai Volcanic Eruption
Authors: Schnepf N. R. , Minami T. , Toh H. , Nair M. C.
Published: May 2022

On 15 January 2022, at around 04:00 UTC, the submarine volcano Hunga Tonga‐Hunga Ha'apai explosively erupted. We examine data from 10 Pacific Ocean geomagnetic observatories and process the data using both high pass filters and cross‐wavelet analyses to enable evaluating the time‐frequency characteristics of the magnetic signals across the Pacific region. At the Western Samoa observatory (API), magnetic signals of 3–8 min period, and visible in both vertical and horizontal fields, arrived at ∼04:44 UTC. The observatories at Chichijima Island (CBI) and Easter Island (IPM) both had local magnetic signatures concurrent with the eruption's water wave arrival and period ranges from, respectively, 13–93 and 5–100+ min. At CBI and IPM, the magnetic signal may be due to both the eruption's tsunami water wave and atmospheric/ionospheric sources. Our results suggest that the magnetic signatures from the eruption are identifiable and may be further separated in future studies.
Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enteroviruses in lake water
Authors: Corre Marie-Hélène , Bachmann Virginie , Kohn Tamar
Published: May 2022

Enteroviruses are ubiquitous contaminants of surface waters, yet their fate in presence of microbial congeners is poorly understood. In this work, we investigated the inactivation of Echovirus-11 (E11) and Coxsackievirus-A9 (CVA9) by bacteria isolated from Lake Geneva. Incubation of E11 or CVA9 in biologically active lake water caused inactivation of 2- and 4-log10, respectively, within 48 h. To evaluate the antiviral action of individual bacterial species, we isolated 136 bacterial strains belonging to 31 genera from Lake Geneva. The majority of isolates (92) induced decay of at least 1.5-log10 of CVA9, whereas only 13 isolates induced a comparable inactivation on E11. The most extensive viral decay was induced by bacterial isolates producing matrix metalloproteases (MMPs). Correspondingly, the addition of a specific MMP inhibitor to lake water reduced the extent of inactivation for both viruses. A lesser, though significant protective effect was also observed with inhibitors of chymotrypsin-like or trypsin-like proteases, suggesting involvement of serine proteases in enterovirus inactivation in natural systems. Overall, we demonstrate the direct effect of bacterial proteases on the inactivation of enteroviruses and identify MMPs as effective controls on enteroviruses’ environmental persistence.
Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review
Authors: Zheng Carmen Jiamin , Van Drunen Sarah , Egorova-Brumley Natalia
Published: May 2022

The relationship between pain and depression is thought to be bidirectional and the underlying neurobiology ‘shared’ between the two conditions. However, these claims are often based on qualitative comparisons of brain regions implicated in pain or depression, while focused quantitative studies of the neurobiology of pain-depression comorbidity are lacking. Particularly, the direction of comorbidity, i.e., pain with depression vs. depression with pain, is rarely addressed. In this systematic review (PROSPERO registration CRD42020219876), we aimed to delineate brain correlates associated with primary pain with concomitant depression, primary depression with concurrent pain, and equal pain and depression comorbidity, using activation likelihood estimation (ALE) meta-analysis. Neuroimaging studies published in English until the 28th of September 2021 were evaluated using PRISMA guidelines. A total of 70 studies were included, of which 26 reported stereotactic coordinates and were analysed with ALE. All studies were assessed for quality by two authors, using the National Institute of Health Quality Assessment Tool. Our results revealed paucity of studies that directly investigated the neurobiology of pain-depression comorbidity. The ALE analysis indicated that pain with concomitant depression was associated with the right amygdala, while depression with concomitant pain was related primarily to the left dorsolateral prefrontal cortex (DLPFC). We provide evidence that pain and depression have a cumulative negative effect on a specific set of brain regions, distinct for primary diagnosis of depression vs. pain.
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice
Authors: Yan Meiling , Li Yun , Luo Qingmao , Zeng Wenru , Shao Xiaoqi , Li Lun , Wang Qing , Wang Dongwei , Zhang Yue , Diao Hongtao , Rong Xianglu , Bai Yunlong , Guo Jiao
Published: May 2022

Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been suggested to contribute to the pathogenesis of cardiovascular diseases. However, whether cGAS-STING is involved in the development of DCM has not been established. Our study aimed to determine the role of cGAS-STING in the initiation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome-induced cardiac pyroptosis and chronic inflammation during the pathogenesis of DCM. C57BL/6J mice were preinjected with adeno-associated virus 9 (AAV9) intravenously via the tail vein to specifically knock down myocardial STING. After four weeks, mice with myocardium-specific knockdown of STING received injections of streptozotocin (STZ; 50 mg/kg) and a high-fat diet to induce diabetes. Measurements included echocardiography, immunohistochemical analyses, wheat germ agglutinin (WGA) staining, and western blotting. Here, we showed that the cGAS-STING signaling pathway was activated in diabetic hearts, which was indicated by the increased phosphorylation of TANK-binding kinase 1 (TBK1) and interferon (IFN) regulatory factor 3 (IRF3), leading to the activation of the NLRP3 inflammasome in the hearts of diabetic mice and proinflammatory cytokine release into serum. Moreover, STING knockdown via adeno-associated virus-9 (AAV9) in diabetic mouse heart alleviated cardiac pyroptosis and the inflammatory response, prevented diabetes-induced hypertrophy, and restored cardiac function. Mechanistically, we showed that palmitic acid (PA)-induced lipotoxicity impairs mitochondrial homeostasis, producing excessive mitochondrial reactive oxygen species (mtROS), which results in oxidative damage to mitochondrial DNA (mtDNA) and its release into the cytoplasm while switching on cGAS-STING-mediated pyroptosis in cardiomyocytes, thereby worsening the progression of diabetic cardiomyopathy. Our study demonstrated that activation of the cGAS-STING pathway caused by mitochondrial oxidative damage and mtDNA escape induced by free fatty acids promoted pyroptosis and proinflammatory responses in cardiomyocytes in a NLRP3 inflammasome-dependent manner, thus promoting myocardial hypertrophy during the progression of DCM.
Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits
Authors: Choudhury Ananyo , Brandenburg Jean-Tristan , Chikowore Tinashe , Sengupta Dhriti , Boua Palwende Romuald , Crowther Nigel J. , Agongo Godfred , Asiki Gershim , Gómez-Olivé F. Xavier , Kisiangani Isaac , Maimela Eric , Masemola-Maphutha Matshane , Micklesfield Lisa K. , Nonterah Engelbert A. , Norris Shane A. , Sorgho Hermann , Tinto Halidou , Tollman Stephen , Graham Sarah E. , Willer Cristen J. ,   AWI-Gen study,   H3Africa Consortium, Hazelhurst Scott , Ramsay Michèle
Published: May 2022

Genetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a sub-Saharan-African GWAS for lipid traits in the population cross-sectional AWI-Gen cohort (N = 10,603) we report a novel LDL-C association in theGATBregion (P-value=1.56 × 10−8). Meta-analysis with four other African cohorts (N = 23,718) provides supporting evidence for the LDL-C association with theGATB/FHIP1Aregion and identifies a novel triglyceride association signal close to theFHITgene (P-value =2.66 × 10−8). Our data enable fine-mapping of several well-known lipid-trait loci includingLDLR, PMFBP1andLPA. The transferability of signals detected in two large global studies (GLGC and PAGE) consistently improves with an increase in the size of the African replication cohort. Polygenic risk score analysis shows increased predictive accuracy for LDL-C levels with the narrowing of genetic distance between the discovery dataset and our cohort. Novel discovery is enhanced with the inclusion of African data.
Observation of spin-current striction in a magnet
Authors: Arisawa Hiroki , Shim Hang , Daimon Shunsuke , Kikkawa Takashi , Oikawa Yasuyuki , Takahashi Saburo , Ono Takahito , Saitoh Eiji
Published: May 2022

The interplay among magnetization and deformation of solids has long been an important issue in magnetism, the elucidation of which has made great progress in material physics. Controlling volume and shapes of matter is now indispensable to realizing various actuators for precision machinery and nanotechnology. Here, we show that the volume of a solid can be manipulated by injecting a spin current: a spin current volume effect (SVE). By using a magnet Tb0.3Dy0.7Fe2 exhibiting strong spin-lattice coupling, we demonstrate that the sample volume changes in response to a spin current injected by spin Hall effects. Theoretical calculation reflecting spin-current induced modulation of magnetization fluctuation well reproduces the experimental results. The SVE expands the scope of spintronics into making mechanical drivers.
Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy
Authors: Wang Fei , Chen Ying , Rao Weidong , Ackermann Lutz , Wang Shun-Yi
Published: May 2022

Disulfides are widely found in natural products and find a wide range of applications in life sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on oxidative couplings of two sulfur containing compounds. This strategy has many side reactions and other shortcomings. Herein, we describe the reductive nickel-catalyzed cross-electrophile coupling of unactivated alkyl bromides with symmetrical alkyl- and aryltetrasulfides to form alkyl-alkyl and aryl-alkyl unsymmetrical disulfides. This approach for disulfide synthesis is practical, relies on easily available, unfunctionalized substrates, and is scalable. We investigated the mechanism of this transformation and found that the tetrasulfide compound does not selectively break the central S–S bond, but regio-selectively generates trisulfide intermediates.
Neural sampling machine with stochastic synapse allows brain-like learning and inference
Authors: Dutta Sourav , Detorakis Georgios , Khanna Abhishek , Grisafe Benjamin , Neftci Emre , Datta Suman
Published: May 2022

Many real-world mission-critical applications require continual online learning from noisy data and real-time decision making with a defined confidence level. Brain-inspired probabilistic models of neural network can explicitly handle the uncertainty in data and allow adaptive learning on the fly. However, their implementation in a compact, low-power hardware remains a challenge. In this work, we introduce a novel hardware fabric that can implement a new class of stochastic neural network called Neural Sampling Machine (NSM) by exploiting the stochasticity in the synaptic connections for approximate Bayesian inference. We experimentally demonstrate an in silico hybrid stochastic synapse by pairing a ferroelectric field-effect transistor (FeFET)-based analog weight cell with a two-terminal stochastic selector element. We show that the stochastic switching characteristic of the selector between the insulator and the metallic states resembles the multiplicative synaptic noise of the NSM. We perform network-level simulations to highlight the salient features offered by the stochastic NSM such as performing autonomous weight normalization for continual online learning and Bayesian inferencing. We show that the stochastic NSM can not only perform highly accurate image classification with 98.25% accuracy on standard MNIST dataset, but also estimate the uncertainty in prediction (measured in terms of the entropy of prediction) when the digits of the MNIST dataset are rotated. Building such a probabilistic hardware platform that can support neuroscience inspired models can enhance the learning and inference capability of the current artificial intelligence (AI).
Translaminar recurrence from layer 5 suppresses superficial cortical layers
Authors: Onodera Koun , Kato Hiroyuki K.
Published: May 2022

Information flow in the sensory cortex has been described as a predominantly feedforward sequence with deep layers as the output structure. Although recurrent excitatory projections from layer 5 (L5) to superficial L2/3 have been identified by anatomical and physiological studies, their functional impact on sensory processing remains unclear. Here, we use layer-selective optogenetic manipulations in the primary auditory cortex to demonstrate that feedback inputs from L5 suppress the activity of superficial layers regardless of the arousal level, contrary to the prediction from their excitatory connectivity. This suppressive effect is predominantly mediated by translaminar circuitry through intratelencephalic neurons, with an additional contribution of subcortical projections by pyramidal tract neurons. Furthermore, L5 activation sharpened tone-evoked responses of superficial layers in both frequency and time domains, indicating its impact on cortical spectro-temporal integration. Together, our findings establish a translaminar inhibitory recurrence from deep layers that sharpens feature selectivity in superficial cortical layers.
Activation of Xist by an evolutionarily conserved function of KDM5C demethylase
Authors: Samanta Milan Kumar , Gayen Srimonta , Harris Clair , Maclary Emily , Murata-Nakamura Yumie , Malcore Rebecca M. , Porter Robert S. , Garay Patricia M. , Vallianatos Christina N. , Samollow Paul B. , Iwase Shigeki , Kalantry Sundeep
Published: May 2022

XXfemale andXYmale therian mammals equalize X-linked gene expression through the mitotically-stable transcriptional inactivation of one of the two X chromosomes in female somatic cells. Here, we describe an essential function of the X-linked homolog of an ancestral X-Y gene pair,Kdm5c-Kdm5d, in the expression of Xist lncRNA, which is required for stable X-inactivation. Ablation ofKdm5cfunction in females results in a significant reduction in Xist RNA expression.Kdm5cencodes a demethylase that enhancesXistexpression by converting histone H3K4me2/3 modifications into H3K4me1. Ectopic expression of mouse and humanKDM5C, but not the Y-linked homologKDM5D, inducesXistin male mouse embryonic stem cells (mESCs). Similarly, marsupial (opossum)Kdm5cbut notKdm5dalso upregulatesXistin male mESCs, despite marsupials lackingXist, suggesting that the KDM5C function that activatesXistin eutherians is strongly conserved and predates the divergence of eutherian and metatherian mammals. In support, prototherian (platypus)Kdm5calso inducesXistin male mESCs. Together, our data suggest that eutherian mammals co-opted the ancestral demethylase KDM5C during sex chromosome evolution to upregulateXistfor the female-specific induction of X-inactivation.
Effects of Alzheimer’s genetic risk scores and CSF biomarkers in de novo Parkinson’s Disease
Authors: Lee Young-gun , Jeong Seong Ho , Park Mincheol , Kang Sung Woo , Baik Kyoungwon , Jeon Seun , Lee Phil Hyu , Sohn Young Ho , Ye Byoung Seok
Published: May 2022

Coexisting Alzheimer’s disease (AD) pathology is common in Parkinson’s disease (PD). However, the implications of genetic risk scores (GRS) for AD have not been elucidated in PD. In 413 de novo PD and 195 healthy controls from the Parkinson’s Progression Marker Initiative database, the effects of GRS for AD (GRS-AD) and PD (GRS-PD) on the risk of PD and longitudinal CSF biomarkers and clinical outcomes were explored. Higher GRS-PD and lower baseline CSF α-synuclein were associated with an increased risk of PD. In the PD group, GRS-AD was correlated positively with CSF p-tau/Aβ and negatively with CSF α-synuclein. Higher GRS-PD was associated with faster CSF p-tau/Aβ increase, and GRS-AD and GRS-PD were interactively associated with CSF α-synuclein. In the PD group, higher GRS-AD was associated with poor visuospatial function, and baseline CSF p-tau/Aβ was associated with faster cognitive decline. Higher GRS-PD was associated with better semantic fluency and frontal-related cognition and motor function given the same levels of CSF biomarkers and dopamine transporter uptake. Taken together, our results suggest that higher GRS-AD and CSF p-tau/Aβ, reflecting AD-related pathophysiology, may be associated with cognitive decline in PD patients.
Mechanisms of peripheral levodopa resistance in Parkinson’s disease
Authors: Beckers Milan , Bloem Bastiaan R. , Verbeek Marcel M.
Published: May 2022

Parkinson’s disease (PD) is an increasingly common neurodegenerative condition. The disease has a significant negative impact on quality of life, but a personalized management approach can help reduce disability. Pharmacotherapy with levodopa remains the cornerstone of treatment, and a gratifying and sustained response to this treatment is a supportive criterion that argues in favor of an underlying diagnosis of PD. Yet, in daily practice, it is not uncommon to encounter patients who appear to have true PD, but who nevertheless seem to lose the responsiveness to levodopa (secondary non-responders). Some patients may even fail to respond altogether (primary non-responders). Here, we address how two mechanisms of “peripheral resistance” may underlie this failing response to levodopa in persons with PD. The first explanation relates to impaired bowel motility leading to secondary bacterial overgrowth, and more specifically, to the excessive bacterial production of the enzyme tyrosine decarboxylase (TDC). This enzyme may convert levodopa to dopamine in the gut, thereby hampering entry into the circulation and, subsequently, into the brain. The second explanation relates to the systemic induction of the enzyme aromatic l-amino acid decarboxylase (AADC), leading to premature conversion of levodopa into dopamine, again limiting the bioavailability within the brain. We discuss these two mechanisms and focus on the clinical implications, potential treatments and directions for future research.
Using machine learning to predict COVID-19 infection and severity risk among 4510 aged adults: a UK Biobank cohort study
Authors: Willette Auriel A. , Willette Sara A. , Wang Qian , Pappas Colleen , Klinedinst Brandon S. , Le Scott , Larsen Brittany , Pollpeter Amy , Li Tianqi , Mochel Jonathan P. , Allenspach Karin , Brenner Nicole , Waterboer Tim
Published: May 2022

Many risk factors have emerged for novel 2019 coronavirus disease (COVID-19). It is relatively unknown how these factors collectively predict COVID-19 infection risk, as well as risk for a severe infection (i.e., hospitalization). Among aged adults (69.3 ± 8.6 years) in UK Biobank, COVID-19 data was downloaded for 4510 participants with 7539 test cases. We downloaded baseline data from 10 to 14 years ago, including demographics, biochemistry, body mass, and other factors, as well as antibody titers for 20 common to rare infectious diseases in a subset of 80 participants with 124 test cases. Permutation-based linear discriminant analysis was used to predict COVID-19 risk and hospitalization risk. Probability and threshold metrics included receiver operating characteristic curves to derive area under the curve (AUC), specificity, sensitivity, and quadratic mean. Model predictions using the full cohort were marginal. The “best-fit” model for predicting COVID-19 risk was found in the subset of participants with antibody titers, which achieved excellent discrimination (AUC 0.969, 95% CI 0.934–1.000). Factors included age, immune markers, lipids, and serology titers to common pathogens like human cytomegalovirus. The hospitalization “best-fit” model was more modest (AUC 0.803, 95% CI 0.663–0.943) and included only serology titers, again in the subset group. Accurate risk profiles can be created using standard self-report and biomedical data collected in public health and medical settings. It is also worthwhile to further investigate if prior host immunity predicts current host immunity to COVID-19.
Spatiotemporal characteristics of ground microtremor in advance of rockfalls
Authors: Yang Yi-Rong , Lee Tzu-Tung , Wang Tai-Tien
Published: May 2022

Identifying cliffs that are prone to fall and providing a sufficient lead time for rockfall warning are crucial steps in disaster risk reduction and preventive maintenance work, especially that led by local governments. However, existing rockfall warning systems provide uncertain rockfall location forecasting and short warning times because the deformation and cracking of unstable slopes are not sufficiently detected by sensors before the rock collapses. Here, we introduce ground microtremor signals for early rockfall forecasting and demonstrate that microtremor characteristics can be used to detect unstable rock wedges on slopes, quantitatively describe the stability of slopes and lengthen the lead time for rockfall warning. We show that the change in the energy of ground microtremors can be an early precursor of rockfall and that the signal frequency decreases with slope instability. This finding indicates that ground microtremor signals are remarkably sensitive to slope stability. We conclude that microtremor characteristics can be used as an appropriate slope stability index for early rockfall warning systems and predicting the spatiotemporal characteristics of rockfall hazards. This early warning method has the advantages of providing a long lead time and on-demand monitoring, while increasing slope stability accessibility and prefailure location detectability.
Regression-based gap-filling methods show air temperature reductions and wind pattern changes during the 2019 total eclipse in Chile
Authors: Hammann Arno C. , MacDonell Shelley
Published: May 2022

Singular disruptive events like solar eclipses affect the measured values of meteorological variables at the earth’s surface. To quantify such an impact, it is necessary to estimate what value the parameter would have taken had the event not occurred. We design and compare several methods to perform such an estimate based on longer observational timeseries from individual meteorological surface stations. Our methods are based on regularised regressions (including a Bayesian variant) and provide both a point an associated error estimate of the disruptive event’s impact. With their help, we study the effect of the total solar eclipse of July 2nd, 2019, in the Coquimbo Region of Chile, on near-surface air temperatures and winds. The observational data used have been collected by the meteorological surface station network of the Centro de Estudios Avanzados en Zonas Áridas (CEAZA). Most stations inside the eclipse’s umbra registered a temperature drop of 1–2 $$^{\circ }$$

∘

C, while the most extreme estimated temperature drop surpassed 6 $$^{\circ }$$

∘

C. The presence of an ‘eclipse cyclone’ can neither be proven nor refuted. Application of the regression methods to other comparable problems like volcanic eruptions, forest fires, or simply gap filling of observational data, are conceivable.
The nasal microbiome of predicting bronchopulmonary dysplasia in preterm infants
Authors: Xu Yanping , Huang Yeqing , Shen Zhen , Shi Liping
Published: May 2022

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity and may cause substantial long-term disabilities. To characterize and compare the nasal swabs microbiome of early stage in premature infants and determine whether microbial diversity or composition in the nostrils associated with BPD disease. We performed a prospective observational cohort design. Preterm neonates less than or equal to 30 weeks of gestation were recruited from NICU, Children's Hospital, Zhejiang University School of Medicine from 2019 to 2020. Sterile foam swabs were collected from anterior nares at 1 and 3 weeks of postnatal age. We used PCR amplification and 16S rDNA sequencing. Neonatal demographic data including gestational age, birth weight, medication administration history and discharge outcomes were recorded. A total of 49 nasal swab samples were collected from 28 premature infants. Thirteen infants with BPD and 15 controls were finally involved in the study. Birth weights ranged from 700 to 1550 g. Gestational age ranged from 252/7 to 30. We found increased in the expression of Prevotella and decreased of Caulobacter in BPD group at both times. Prevotella and Caulobacter were correlated with the severity of BPD (Spearman r = 0.551, r = − 0.545; P = 0.00005, 0.00006; respectively). Receiver operating characteristic analysis showed that the area under characteristic curve of Caulobacter model at first week reached 0.821 and Prevotella model at third week was 0.796. Moreover, microbial functional prediction analysis revealed that ABC-type transports were distinctively changed in BPD group. In summary, the use of non-invasive nasal swabs of microbiome to explore the pathophysiology in BPD is a compelling method worthy continuing to expand and research.
Modern aridity in the Altai-Sayan mountain range derived from multiple millennial proxies
Authors: Churakova-Sidorova Olga V. , Myglan Vladimir S. , Fonti Marina V. , Naumova Oksana V. , Kirdyanov Alexander V. , Kalugin Ivan A. , Babich Valery V. , Falster Georgina M. , Vaganov Eugene A. , Siegwolf Rolf T. W. , Saurer Matthias
Published: May 2022

Temperature and precipitation changes are crucial for larch trees growing at high-elevation sites covered by permafrost in the Altai-Sayan mountain range (ASMR). To contextualize the amplitude of recent climate fluctuations, we have to look into the past by analyzing millennial paleoclimatic archives recording both temperature and precipitation. We developed annually resolved 1500-year tree-ring cellulose chronologies (δ13Ccell, δ18Ocell), and used these new records to reconstruct the variability in local summer precipitation and air temperature. We combined our new local reconstructions with existing paleoclimatic archives available for the Altai. The data show a strong decreasing trend by ca. 49% in regional summer precipitation, along with a regional summer temperature increase towards the twenty-first century, relative to the preceding 1500 years. Modern dry conditions (1966–2016 CE) in the ASMR are the result of simultaneous summer warming and decreased precipitation. Our new reconstructions also demonstrate that climate change in the ASMR is much stronger compared to the global average.
Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury
Authors: Huang Ruyi , Nikooyan Ali A. , Moore Lisa D. , Zdunowski Sharon , Morikawa Erika , Sierro Tiffany , Sayenko Dimitry , Gad Parag , Homsey Tali , Le Timothy , Madhavan Meghna A. , Abdelshahid Marina , Abdelshahid Martina , Zhou Yan , Nuwer Mark R. , Sarrafzadeh Majid , Edgerton V. Reggie , Leiter James C. , Lu Daniel C.
Published: May 2022

Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical spinal cord stimulation (tSCS), with or without systemic serotonergic treatment with buspirone (busp), could improve hand function in individuals with severe hand paralysis following SCI, we assessed ten subjects in a double-blind, sham-controlled, crossover study. All treatments—busp, tSCS, and the busp plus tSCS—reduced muscle tone and spasm frequency. Buspirone did not have any discernible impact on grip force or manual dexterity when administered alone or in combination with tSCS. In contrast, grip force, sinusoidal force generation and grip-release rate improved significantly after 6 weeks of tSCS in 5 out of 10 subjects who had residual grip force within the range of 0.1–1.5 N at the baseline evaluation. Improved hand function was sustained in subjects with residual grip force 2–5 months after the tSCS and buspirone treatment. We conclude that tSCS combined with training improves hand strength and manual dexterity in subjects with SCI who have residual grip strength greater than 0.1 N. Buspirone did not significantly improve the hand function nor add to the effect of stimulation.
Perceptually motivated loss functions for computer generated holographic displays
Authors: Yang Fan , Kadis Andrew , Mouthaan Ralf , Wetherfield Benjamin , Kaczorowski Andrzej , Wilkinson Timothy D.
Published: May 2022

Understanding and improving the perceived quality of reconstructed images is key to developing computer-generated holography algorithms for high-fidelity holographic displays. However, current algorithms are typically optimized using mean squared error, which is widely criticized for its poor correlation with perceptual quality. In our work, we present a comprehensive analysis of employing contemporary image quality metrics (IQM) as loss functions in the hologram optimization process. Extensive objective and subjective assessment of experimentally reconstructed images reveal the relative performance of IQM losses for hologram optimization. Our results reveal that the perceived image quality improves considerably when the appropriate IQM loss function is used, highlighting the value of developing perceptually-motivated loss functions for hologram optimization.
Optimization of DMD-based independent amplitude and phase modulation by analysis of target complex wavefront
Authors: Georgieva Alexandra , Belashov Andrey V. , Petrov Nikolay V.
Published: May 2022

The paper presents the results of a comprehensive study on the optimization of independent amplitude and phase wavefront manipulation which is implemented using a binary digital micromirror device. The study aims to investigate the spatial resolution and quantization achievable using this approach and its optimization based on the parameters of the target complex wave and the modulation error estimation. Based on a statistical analysis of the data, an algorithm for selecting parameters (carrier frequency of binary pattern and aperture for the first diffraction order filtering) that ensures the optimal quality of the modulated wavefront was developed. The algorithm takes into account the type of modulation, that is, amplitude, phase, or amplitude-phase, the size of the encoded distribution, and its requirements for spatial resolution and quantization. The results of the study will greatly contribute to the improvement of modulated wavefront quality in various applications with different requirements for spatial resolution and quantization.
Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity
Authors: Chen Pei-Ying , Kang Eugene Yu-Chuan , Chen Kuan-Jen , Ling Xiao Chun , Chang Yin-Hsi , Wang Nan-Kai , Liu Laura , Chen Yen-Po , Hwang Yih-Shiou , Lai Chi-Chun , Wu Wei-Chi
Published: May 2022

There has been limited research regarding the status of foveal hypoplasia and the characteristics of the optical components of the eye in patients with familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP). In this retrospective cohort study, patients were classified into five groups: patients with stage 1 and 2 FEVR (FEVR group), patients with ROP who received treatment (treated ROP group), patients with ROP who did not receive treatment (untreated ROP group), patients without ROP who had been born preterm (preterm group), and healthy patients who had been born at term (full-term group). Visual acuity, refractive error, characteristics of the optical components, and features of the fovea were compared. In total, 179 eyes from 100 patients were included. Patients in the FEVR group had the highest degrees of myopia (p < 0.001). The axial length of patients in the FEVR group was significantly longer than that of patients in the treated and untreated ROP, preterm, and full-term groups (p < 0.001, p < 0.001, p = 0.001, and p = 0.003, respectively). Patients in the FEVR group had a higher proportion of grade 4 foveal hypoplasia and thinner foveae than those in the other groups (p < 0.001). Patients with FEVR had significantly greater myopic change than patients with ROP; the significantly longer axial length of the FEVR group might be the reason for the greater myopic change and lesser macular thickness. Patients in the FEVR group had more foveal hypoplasia than those in the other groups.
Design and evaluation of 3D-printed auxetic structures coated by CWPU/graphene as strain sensor
Authors: Choi Hyeong Yeol , Shin Eun Joo , Lee Sun Hee
Published: May 2022

A strain sensor characterized by elasticity has recently been studied in various ways to be applied to monitoring humans or robots. Here, 4 types of 3D-printed auxetic lattice structures using thermoplastic polyurethane as raw material were characterized: truss and honeycomb with positive Poisson's ratio and chiral truss and re-entrant with negative Poisson's ratio. Each structure was fabricated as a flexible and stable strain sensor by coating graphene through a dip-coating process. The fabricated auxetic structures have excellent strength, flexibility, and electrical conductivity desirable for a strain sensor and detect a constant change in resistance at a given strain. The 3D-printed auxetic lattice 4 type structures coated with CWPU/Graphene suggest potential applications of multifunctional strain sensors under deformation.
A statistical shape model of soleus muscle morphology in spastic cerebral palsy
Authors: Bin Ghouth Salim G. , Williams Sian A. , Reid Siobhan L. , Besier Thor F. , Handsfield Geoffrey G.
Published: May 2022

This study investigated morphological characteristics of the soleus muscle in cerebral palsy (CP) and typically developing (TD) cohorts using a statistical shape model and differentiated dominant features between the two cohorts. We generated shape models of CP and TD cohorts to characterize dominant features within each. We then generated a combined shape model of both CP and TD to assess deviations of the cohorts’ soleuses from a common mean shape, and statistically analysed differences between the cohorts. The shape models revealed similar principal components (PCs) with different variance between groups. The CP shape model yielded a distinct feature (superior–inferior shift of the broad central region) accounting for 8.1% of the model’s cumulative variance. The combined shape model presented two PCs where differences arose between CP and TD cohorts: size and aspect ratio of length–width–thickness. The distinct appearance characteristic in the CP model—described above—may implicate impaired muscle function in children with CP. Overall, children with CP had smaller muscles that also tended to be long, thin, and narrow. Shape modelling captures dominant morphological features of structures, which was used here to quantitatively describe CP muscles and further probe our understanding of the disease’s impact on the muscular system.
Nature and happiness in an individualist and a collectivist culture
Authors: Svoray Tal , Dorman Michael , Abu-Kaf Sarah , Shahar Golan , Gifford Robert
Published: May 2022

According to the attention restoration theory, exposure to nature (ETN) renews one's capacity to focus attention, which decreases cognitive fatigue and therefore may increase positive emotions. Indeed, natural settings have been associated with high prevalence of happy facial expressions (HFE). However, how universal the association is, remains unclear. We explored the ETN-HFE association in Boston, US, representing a less collectivistic culture, and Yokohama, Japan, representing a more collectivistic one. Evidence from satellite images and social network data, using geoinformatics and statistical tools, revealed that individuals from both societies exhibited more happiness when they were photographed in more natural settings. These associations varied with temporal variations expressed through weekly and annual effects. In addition, we found that the presence of others was also associated with prevalence of HFE in natural settings at Yokohama and Boston but the relation was significantly stronger in Boston. Despite some relatively minor differences between the countries, these results support the universality of the association between ETN and HFE.
Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor
Authors: Ramírez-Moya Julia , Wert-Lamas León , Acuña-Ruíz Adrián , Fletcher Alice , Wert-Carvajal Carlos , McCabe Christopher J. , Santisteban Pilar , Riesco-Eizaguirre Garcilaso
Published: May 2022

Thyroid cancer is the most common primary endocrine malignancy in adults and its incidence is rapidly increasing. Long non-coding RNAs (lncRNAs), generally defined as RNA molecules longer than 200 nucleotides with no protein-encoding capacity, are highly tissue-specific molecules that serve important roles in gene regulation through a variety of different mechanisms, including acting as competing endogenous RNAs (ceRNAs) that ‘sponge’ microRNAs (miRNAs). In the present study, using an integrated approach through RNA-sequencing of paired thyroid tumor and non-tumor samples, we have identified an interactome network between lncRNAs and miRNAs and examined the functional consequences in vitro and in vivo of one of such interactions. We have identified a likely operative post-transcriptional regulatory network in which the downregulated lncRNA, SPTY2D1-AS1, is predicted to target the most abundant and upregulated miRNAs in thyroid cancer, particularly miR-221, a well-known oncomiRNA in cancer. Indeed, SPTY2D1-AS1 functions as a potent tumor suppressor in vitro and in vivo, it is downregulated in the most advanced stages of human thyroid cancer, and it seems to block the processing of the primary form of miR-221. Overall, our results link SPTY2D1-AS1 to thyroid cancer progression and highlight the potential use of this lncRNA as a therapeutic target of thyroid cancer.