bluuebunny/crossref_metadata_2025 huggingface dataset:
Cybersecurity Attack Detection using Gradient Boosting Classifier
Authors: Kumar N. Chaitanya , Sabeena Jasmine
Published: December 2023

In the rapidly evolving digital landscape, cybersecurity attacks have become increasingly sophisticated, posing monumental threats to organi- zations and individuals alike. Among the myriad of cyber threats, our focus in this paper is on detecting anomalies indicative of potential cy- ber attacks, specifically targeting network traffic. Detecting these attacks promptly and accurately is not just a technical challenge but a necessity to ensure data integrity, user trust, and operational continuity. This paper presents a comprehensive approach to detect such cybersecurity anoma- lies using the Gradient Boosting Classifier, a machine learning algorithm renowned for its predictive prowess. Our proposed solution encompasses advanced data preprocessing techniques, meticulous feature engineering, and rigorous model evaluation metrics. The applications of such a detec- tion system are vast, spanning across sectors like finance, healthcare, and e-commerce, acting as a bulwark against data breaches and unauthorized intrusions. The paper outlines our methodology, from data acquisition and preprocessing to modeling and evaluation, providing a blueprint for effective cyber attack detection.
Weaning protocol to reduce mechanical ventilation time in children admitted to pediatric intensive care units: Protocol for a Systematic Review and Meta-Analysis
Authors: Almeida Suzana Cristina , Souza Rayany Cristina , Azevedo Ingrid Guerra , Silva Ivanízia Soares da , Azevedo Vivian Mara Gonçalves de Oliveira
Published: December 2023

Background
Invasive Mechanical ventilation (IMV) is necessary for most Pediatric Intensive Care Units (PICU) patients. Although it is a complex process, weaning should be performed as soon as possible due to the adverse effects of IMV. This review aims to identify whether the use of a weaning protocol in a PICU, compared to usual care, can reduce the duration of IMV, length of stay in the PICU, mortality, and adverse events in children.
Methods
The strategy review and selective reports were developed using the population, intervention, comparison, outcome, and study design (PICOS) format. PUBMED, EMBASE, CINHAL, Web of Science, Cochrane Central Register of Controlled Trials, International Clinical Trials Registration Platform, and gray literature will be systematically searched for randomized controlled trials (RCTs). The studies’ methods should have been compared to protocol and nonprotocol weaning in children older than 28 days and younger than 18 years old, assisted at the PICU, and mechanically ventilated through an endotracheal tube. The risk of bias will be evaluated using the Cochrane Risk of Bias Tool for Randomized Trials. A meta-analysis will be conducted to compare the differences in the outcomes if at least two studies are sufficiently homogeneous concerning participants, interventions, and outcome measures. Subgroup analyses will also be performed looking for protocol type, indication for IMV, clinical condition, and age group differences.
Discussion
The results will synthesize the weaning protocol in a PICU and compare it to usual care to provide information to guide the pediatric intensivist therapist in weaning children from mechanical ventilation.
Systematic review registration: PROSPERO CRD42023399650.
A molecular T-pentomino for separating BTEX hydrocarbons
Authors: MacGillivray Leonard , Hartwick Christopher , Reinheimer Eric
Published: December 2023

The development of methods to separate molecules (e.g., petrochemicals) are exceedingly important industrially, particularly to purify fuels and polymer precursors.1 A common approach for separations is to crystallize an organic molecule that acts as a host by either providing an enforced covalent cavity (intrinsic cavity) or that packs inefficiently (extrinsic cavity).2 Here we report a self-assembled molecule with a shape that is highly biased to completely enclosed space and, thereby, pack efficiently yet has the property of hosting and allowing for the separation of BTEX hydrocarbons (i.e., benzene, toluene, ethylbenzene, xylenes).1 The components of the host are held together by N→B bonds and form a diboron assembly with a molecular shape that conforms to a T-shaped pentomino.3 A T-pentomino is a polyomino, which is a plane figure that tiles a plane without cavities and holes, and we show the T-shaped molecule to crystallize into one of six limited polymorphic structures for T-pentomino tiling.4 The separations of the BTEX hydrocarbons occur at mild conditions while rejecting similarly shaped aromatics such as xylene isomers, thiophene, and styrene. Our observation on the structure and tiling of the host to conform to a T-pentomino allows us to develop a theory on how novel synthetic molecules that mimic the structures and packing of polyominoes3 can be synthesized and - quite counterintuitively - developed into a system of hosts with cavities used for selective and useful separations.
Mechanical and morphological properties of cellulose nanocrystals synthesized from industrial hemp agro-waste
Authors: Heacock Jesse A. , Sun Yu , Li Yan Vivian
Published: December 2023

The rapid increase of industrial hemp growth in the US has resulted in a significant increase of hemp agro-waste, suggesting a need of counteracting the increasing agro-waste and promoting sustainable farming practice. One attractive solution is to treat hemp agro-waste with ammonium persulfate (APS), resulting in cellulose nanocrystals (CNCs) which are biofriendly and environmental-friendly alternatives to petroleum-based materials. However, most existing work on CNC extraction focuses on other cellulose sources such as cotton, wheat, and rice. There has been a lack of work on hemp, particularly hemp agro-waste using APS treatment. In this study, the one-step treatment was followed by purification to remove impurities and hence to colloidally stabilize CNCs in aqueous solutions. The resulting CNCs had an average length of 190 nm and average height of 4 nm. The mechanical analysis of individual CNCs using Force-Distance Spectroscopy suggested a Young’s modulus of 2.19 ± 0.15 GPa, maximum loading force of 6.29 ± 0.09 nN, and adhesion energy of 1.57 ± 1.12e-16 J. No statistical differences between purified and unpurified CNCs were found in Young’s modulus and maximum loading forces measurements, suggesting the impurities had minimum impact on mechanical strength. The results highlight hemp agro-waste as a valuable resource and the one-step APS treatment as an eco-friendly and efficient method to produce CNCs.
Causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study
Authors: He Nan , Li Guangzhao , Zhang Shenghuan , sheng kai
Published: December 2023

Background
As one of the most common gastrointestinal disorders, recent study has shown that dysfunction in the gut microbiota might lead to constipation. However, the causality between the gut microbiota and constipation is unclear.
Methods
Genome-Wide Association Studies (GWAS) used to obtain the summary-level data of constipation through IEU OpenGWAS database, and constipation was used as outcome. In addition, MiBioGen was used to gain the summary data of gut microbiota, including Ruminiclostridium 9, Intestinibacter, Anaerotruncus, Butyricimonas and Hungatella, which were used as exposure factors. Univariable Mendelian randomization (MR) analysis was used to evaluate the causality of gut microbiota on constipation. In briefly, Inverse-variance weighted (IVW) method was regarded as a main method to estimate the causality of gut microbiota and constipation, and supplemented by other four methods, including MR-egger, Weighted median, Simple mode and Weighted mode. Finally, funnel plot, heterogeneity test, horizontal pleiotropy test and leave-one-out test were used to evaluate the reliability of MR results.
Results
Ruminiclostridium 9 and Intestinibacter were causally associated with constipation and were the protective factors for constipation based on the MR analysis of IVW. The causal odds ratio (OR) values of Ruminiclostridium 9 and Intestinibacter were 0.75 (95% confidence interval (CI) 0.73–0.78; P < 0.001) and 0.89 (95% CI 0.86–0.93; P < 0.001) for constipation. Moreover, Anaerotruncus, Butyricimonas and Hungatella were also causally associated with constipation but were the risk factors for constipation. The OR values of Anaerotruncus, Butyricimonas and Hungatella were 1.08 (95% CI 1.02–1.13; P = 0.007), 1.07 (95% CI 1.01–1.13; P = 0.015), 1.03 (95% CI 1.00-1.06; P = 0.037) respectively. Furthermore, validation by funnel plot, heterogeneity test and horizontal pleiotropy test showed that MR results were reliable.
Conclusion
Ruminiclostridium 9, Intestinibacter, Anaerotruncus, Butyricimonas and Hungatella were identified as causalities of constipation, which provided a basis for understanding pathology of constipation and new insights into prevention and treatment.
Comprehensive pan-cancer analysis reveals clinical and immunological significance of ATP7A as a potential biomarker in hepatic carcinoma
Authors: Teng Luojun , Zhao Ruinan , Wang Weishan , Yao Guoxiang
Published: December 2023

Copper death has emerged as a potent tool in clearing cancer cells. The ATPase Copper Transporting Alpha (ATP7A) plays a pivotal role in in maintaining intracellular copper ion homeostasis, yet a comprehensive pan-cancer analysis of its molecular function and clinical relevance remains elusive. In this study, we systematically examined the expression levels of ATP7A across various malignancies using data from the TCGA database, delving into its expression patterns, prognostic significance, potential regulatory impact on the immune microenvironment, as well as its association with tumor mutation burden and microsatellite instability in a pan-cancer context. Our investigation revealed downregulation of ATP7A in colon cancer, ovarian cancer, and pancreatic carcinoma, while observing upregulation in liver hepatocellular carcinoma, lung adenocarcinoma, and glioblastoma. Furthermore, heightened expression of ATP7A was found to be linked to poorer prognosis in Kidney renal clear cell carcinoma and Brain Lower Grade Glioma. Notably, ATP7A demonstrated a positive correlation with immune scores in LGG, and conversely, exhibited a negative correlation with immune scores in bladder urothelial carcinoma, breast invasive carcinoma, lung squamous cell carcinoma, and thyroid carcinoma. Leveraging Cibersortx software for the calculation of immune cell infiltration scores using global gene expression profiles of patients, we observed a strong association between ATP7A expression levels and the abundance of tumor-infiltrating immune cells. Additionally, our analysis unveiled significant correlations between ATP7A expression and PDL1 expression, tumor mutation burden (TMB), and microsatellite instability (MSI), suggesting its potential as a biomarker for immune checkpoint blockade (ICB) therapy. In summary, our study presents an encompassing pan-cancer analysis of ATP7A, providing a foundational framework for ATP7A-based precision medicine strategies.
Pharmacovigilance study of Rucaparib based on the FDA Adverse Event Reporting System(FAERS)
Authors: Fangying Si , Ying Xue , Xiaojing Lu , Zhao Yin , zhang Du Shu
Published: December 2023

Rucaparib was approved for the treatment of ovarian and prostate cancers. The aim of the study was to assess rucaparib-related adverse events (AEs) through data mining using the US Food and Drug Administration Adverse Event Reporting System (FAERS).We analyzed adverse event (AE) reports in the FAERS between 2016 Q4 and 2022 Q2. Disproportionality analyses were performed during data mining to quantify the signals of rucaparib-related AEs. Of 13,638,847 reports collected from the FAERS database, 7436 reports of rucaparib related AEs were identified . A total of 95 preferred terms (PTs) with significant disproportionality in 11 system organ classes (SOCs) were retained. Unexpected significant AEs, such as small intestinal obstruction, intestinal mass, intestinal obstruction, decreased glomerular filtration rate, have been also reported. The median time-to-onset of rucaparib-associated AEs was 32 days (interquartile range [IQR], 15–88 days). Time-to-onset of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) were 525 and 522.5 days, for photosensitivity reaction and sunburn, time-to-onset were 44 and 62 days, and for neuropathy peripheral and taste disorder, time-to-onset were 49.5 and 60.5 days. Our study identified potential new AE signals that might provide important support for clinical monitoring of rucaparib, supporting its rational use in clinical practice.
Balancing Privacy and Explainability in Federated Learning
Authors: Teixeira Rafael , Almeida Leonardo , Rodrigues Pedro , Corona Julio , Antunes Mário , Aguiar Rui L.
Published: December 2023

As we advance towards future generations of communication networks, such as 6G, Artificial Intelligence (AI) and Machine Learning (ML) will assume an increasingly pivotal role in network optimization, management, and operation. In this context, the pursuit of reliability in ML models has emerged as a highly active area of research. Explainable AI (XAI) is an essential tool to unravel the underlying mechanisms of network behaviour, enabling a deeper understanding of the decisions made by black-box models in future-generation networks. This paper investigates the impact of Federated Learning (FL) on explainability by evaluating the correlation between the feature importance derived from models trained using four different FL approaches and the model trained using a conventional single-host approach. The analysis utilizes two publicly available datasets, two XAI metrics, and two correlation metrics. The findings reveal a high correlation between FL and single-host trained models in three of the four FL approaches, suggesting that some FL approaches failed to capture similar patterns.
Impact of directly acting-antivirals and behavior change due to the COVID 19 pandemic on HCV micro-elimination in MSM in Germany
Authors: Ingiliz Patrick , Lutz Thomas , Schewe Knud , Baumgarten Axel , Krznaric Ivanka , Mauss Stefan , Christensen Stefan , Bickel Markus , Schmidt Axel Jeremias , Sabranski Michael , He Feng , Jain Sonia , Martin Nastasha Kaleta , Rockstroh Jürgen K. , Boesecke Christoph
Published: December 2023

Introduction
Directly-acting antivirals (DAA) are the cornerstone to reach HCV elimination. In men who have sex with men (MSM) with HIV coinfection, recently acquired HCV infection (RAHCV) is common. Sexual practices and reinfection rates may hamper micro-elimination despite high treatment rates.
Methods
The cohort included MSM with RAHCV from 2014 to 2021. The patients’ demographic, clinical, behavioral, and laboratory data were documented, as well as treatment and reinfection outcomes.
Results
237 men with RAHCV were included, 216 (91%) were PLWH. Median age was 46 years (IQR: 39–52), median CD4 count was 660/mm3 (IQR: 527–835).
The annual incidence of RAHCV remained between 0.28% and 0.43%, but dropped to 0.02% in 2021 during the onset of the COVID-pandemic almost reaching micro-elimination. The reinfection incidence was 15.5 per 100 patient-years (95%-CI: 12.6-18.8), reinfection was associated with use of crystal methamphetamine (p=0.032) and ketamine (p=0.042). 31.3% had multiple reinfections, four reinfections occurred in PrEP users.
Conclusions
High treatment and cure rates did not lead to HCV elimination. A change in sexual behavior, potentially imposed by COVID-19 restrictions, led to micro-elimination in the NoCo cohort. As RAHCV is prevalent in HIV-positive and -negative MSM, surveillance is necessary to consolidate elimination goals.
How to customize Common Data Models for rare diseases: an OMOP-based implementation and lessons learned
Authors: Ahmadi Najia , Zoch Michele , Guengoeze Oya , Facchinello Carlo , Mondorf Antonia , Stratmann Katharina , Musleh Khader , Erasmus Hans-Peter , Tchertov Jana , Gebler Richard , Schaaf Jannik , Frischen Lena , Nasirian Azadeh , Dai Jiabin , Henke Elisa , Tremblay Douglas , Srisuwananuk Andrew , Bornhäuser Martin , Röllig Christoph , Eckardt Jan-Niklas , Middeke Jan Moritz , Wolfien Markus , Sedlmayr Martin
Published: December 2023

Background
Given the geographical sparsity of Rare Diseases (RDs), assembling a cohort is often a challenging task. Common Data Models (CDM) can harmonize disparate sources of data that can be the basis of decision support systems and artificial intelligence-based studies, leading to new insights in the field. This work is sought to support the design of large-scale multi-center studies for rare diseases.
Methods
In an interdisciplinary group, we derived a list of elements of RDs in three medical domains (endocrinology, gastroenterology, and pneumonology) according to specialist knowledge and clinical guidelines in an iterative process. We then defined a RDs data structure that matched all our data elements and built Extract, Transform, Load (ETL) processes to transfer the structure to a joint CDM. To ensure interoperability of our developed CDM and its subsequent usage for further RDs domains, we ultimately mapped it to Observational Medical Outcomes Partnership (OMOP) CDM. We then included a fourth domain, hematology, as a proof-of-concept and mapped an acute myeloid leukemia (AML) dataset to the developed CDM.
Results
We have developed an OMOP-based rare diseases common data model (RD-CDM) using data elements from the three domains (endocrinology, gastroenterology, and pneumonology) and tested the CDM using data from the hematology domain. The total study cohort included 61,697 patients. After aligning our modules with those of Medical Informatics Initiative (MII) Core Dataset (CDS) modules, we leveraged its ETL process. This facilitated the seamless transfer of demographic information, diagnoses, procedures, laboratory results, and medication modules from our RD-CDM to the OMOP. For the phenotypes and genotypes, we developed a second ETL process. We finally derived lessons learned for customizing our RD-CDM for different RDs.
Discussion
This work can serve as a blueprint for other domains as its modularized structure could be extended towards novel data types. An interdisciplinary group of stakeholders that are actively supporting the project's progress is necessary to reach a comprehensive CDM.
Conclusion
The customized data structure related our RD-CDM can be used to perform multi-center studies to test data-driven hypotheses on a larger scale and take advantage of the analytical tools offered by the OHDSI community.
Young children’s mental well-being in vulnerable South African settings: qualitative insights for Mazi Umntanakho co-design
Authors: Draper Catherine E , Cook Caylee J , Ankrah Elizabeth A , Beltran Jesus A , Cibrian Franceli L , Johnson Jazette , Lakes Kimberley D , Mofid Hanna , Williams Lucretia , Hayes Gillian R
Published: December 2023

As part of the co-design process for the development of the Mazi Umntanakho (‘know your child’) digital tool, this study aimed to capture community perspectives of the risks and protective factors for social emotional development and mental health of young children in vulnerable South Africa settings, through the lens of the nurturing care framework. Twenty focus group discussions (n = 154, 97% female) were held with staff of community-based organisations (CBOs) and community health worker (CHW) programmes in urban and rural sites from four geographical regions. Data was analysed thematically, and grouped according to components of nurturing care (responsive caregiving, safety and security, good health, adequate nutrition, opportunities for early learning) and risk and protective factors. Risks far outweighed protective factors, and the most dominant theme identified was risks associated with responsive caregiving from CBO and CHW perspectives. These related to caregivers’ attitudes, knowledge, beliefs, behaviours, and challenges not conducive to the provision of responsive caregiving. The most common risk to safety and security was substance abuse, along with economic challenges, neglect, abuse and violence. Basic needs not being met was the main risk to adequate nutrition and good health, followed by insufficient services. Limited resources and caregivers’ limited education and literacy were risks to early learning. These findings highlight the urgent need to mitigate risks and amplify protective factors for the social emotional development and mental health of young children in South Africa. It is critical that these are considered within the contextual realities of vulnerable communities.
CFD-FEM simulation of water entry of aluminium flat stiffened plate structure considering the effects of hydroelasticity
Authors:   School of Civil Engineering and Transportation, South China University of Technology, Jiao Jialong
Published: December 2023

In this paper, the slamming loads and structural response of an aluminium flat stiffened-plate structure during calm water entry considering the hydroelasticity effects are studied by a partitioned CFD-FEM two-way coupled method. The target structure is simplified as one segment of an idealized ship grillage structure, comprising flat plate and stiffeners. The typical numerical results are analyzed such as vertical displacement, velocity, acceleration, impact loads, and structural stress of the flexible flat bottom grillage structure considering the hydroelasticity effect and air cushion effect in different free fall height conditions. Drop test results of the same structure and other existing numerical simulation data by both coupled and uncoupled solutions in the literature are used for comparison with the present numerical simulation results. This study provides a practical means to simulate the slamming behaviour and structural response of ship structures, which is useful for predicting ship hull stiffened panel loads and related structural design.
Commonality in Liquidity: Evidence from Emerging Asian Actively-Managed Equity Funds
Authors:   Faculty of Business Administration, Sukkur IBA University, 65200 Sukkur, Sindh, Pakistan, Kumar Suresh , Nor Eliza ,   School of Management, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia, Azman Nik Hadiyan Nik ,   School of Management, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia, Ali Hyder ,   Faculty of Business Administration, Sukkur IBA University, 65200 Sukkur, Sindh, Pakistan
Published: December 2023

In this study, a set of common factors of liquidity that had previously been recorded at the equity security level is examined for its effect on inter and intra-market liquidity variations in equity funds in emerging Asian markets. Cross-market liquidity co-movement between the fund’s portfolio and the market portfolio, which typically measures systematic liquidity risk and market integration, is the liquidity commonality for mutual funds. This research builds on Wang Jianxin’s study in 2013 by including market liquidity, return and volatility as common factors of liquidity, and the partial R2 of the common factors reveals each factor’s contribution. We find that emerging Asian countries share 24.14% of the intra-market liquidity commonality between funds and equity markets, and market liquidity is tied to such relationship. Emerging Asian region share 2.76% of inter-market liquidity commonality and regional market return and volatility majorly contribute to this liquidity commonality. The significance of domestic financial markets is evidenced by the wide disparity in liquidity commonality between domestic and regional markets.
Therapeutic Application of Honey Against Ige-Mediated Type 1 Hypersensitivity Reactions: A Systematic Review
Authors: Quitain Daphne Michaella D , Balasolla Ma. Jenina B , Barber Danielle Krisha S , Cainglet Rencel Shane J , Colorico Junnela F , Escantilla Allyna Kristel R , Palomeno Aira , Quiambao Kristine Claire M , Antig Luis Dominick B
Published: December 2023

In contemporary times, the use of traditional remedies is still evident. One of the primary items foremost emphasized today is honey. Aside from its natural sweetener capacity, modern science highlights its potential therapeutic capabilities, including anti-inflammatory and immunoregulatory properties in different Type I Hypersensitivity conditions. This systematic review analyzed nine credible experimental studies to objectify different types of honey and its application and effect in different Type I Hypersensitivity clinical manifestations. The abundance of evidence granting IgE mediated disorders which includes Allergic Asthma, Vernal Keratoconjunctivitis, Allergic Fungal Rhinosinusitis, Allergic Rhinitis, and Atopic Dermatitis in both preclinical and clinical analysis revealed honey to be a contributing factor in suppressing different clinical manifestations of the associated conditions. The systematic review can evaluate and categorize the potential therapeutic capabilities of honey in different IgE-mediated Type I Hypersensitivity Reactions, thus, enabling a comprehended integration towards assisting the application within the clinical setting.
Do underwriting profit factors affect general insurance firms’ profitability in South Africa?
Authors: Sthembiso Msomi Thabiso
Published: December 2023

This research paper examines the correlation between underwriting profit factors and the overall profitability of publicly traded general insurance companies operating in South Africa. The study analyzed a sample of 36 insurers, considering their quantifiable markets and accessible financial data from 2008 to 2019. Employing signal correlation analysis, the investigation explored the associations between various financial indicators and Return on Assets (ROA). The results revealed negative correlations between ROA and the logarithms of total investment (TI), shareholder funds (SF), and underwriting profits (UWP), with correlation coefficients of –0.4500, –0.3365, and –0.4050, respectively. These findings indicate that as TI, SF, and UWP increase, there is a tendency for ROA to decrease for general insurance companies in South Africa. Furthermore, a positive relationship was observed between the earning-asset ratio and ROA. This suggests that as the earning-asset ratio rises, the ROA of general insurance firms in South Africa tends to improve, indicating a potentially favorable impact on profitability. The significant findings of this study emphasize the importance of prioritizing effective risk management practices within insurance firms. By implementing these measures, such as minimizing the likelihood of claims and ensuring accurate reflection of assumed risks in premium charges, insurance companies can maintain positive underwriting profit. This, in turn, has the potential to enhance their overall profitability.
How is agricultural water efficiency affected by the digital economy? Insights from China
Authors: Chang Ming , Li Fei , Lin Songwei , Zhang Jinhao , Shi Hongxu
Published: December 2023

With the continued advancement of digital technology, the digital economy will gradually become the primary economic form in the future, having a profound impact on a variety of industries, including agriculture. Agriculture is a major source of global water use, and efficient water use in agriculture is critical to coping with water scarcity and ensuring food security. This study used publicly available data from 30 Chinese provinces from 2006 to 2017 to estimate the relationship between the digital economy and agricultural water use efficiency using the systematic generalized method of moments technique. According to the findings, a 1% increase in the digital economy indicator is associated with a 0.053% increase in agricultural water use efficiency. In addition, the digital economy improves agricultural water usage efficiency through three mediating channels: structural effect, scale effect, and spillover effect. For the digital economy and agricultural water use efficiency to develop in tandem, the Chinese government should strive to strengthen the development of the digital economy and work on the intermediate channels demonstrated in this study.
Study on the treatment of corn alcohol wastewater by the internal circulation anaerobic reactor
Authors: Ji Junlin , Xu Guoqin , Yang Hong , Liu Jing , Wang Changmei , Yin Fang , Zhang Wudi , Hao Shumei
Published: December 2023

To comprehensively assess the efficacy of employing the internal circulation (IC) anaerobic reactor for corn alcohol wastewater treatment and investigate its feasibility, this study focused on anaerobic digestion parameters, energy balance, and the composition of the prokaryotic microbial community. During the operation of the reactor, the hydraulic retention time was progressively reduced from 4.8 to 1.6 days while achieving an average organic loading rate of 12.46 kg chemical oxygen demand (COD)/(m3·d). Moreover, the removal rate of COD exceeded 98%, and the energy balance (ΔE) reached 10.29 kJ/g fed COD. The initial manifestation of organic acidosis in the reactor was a decline in gas production, which is primarily caused by propionic acid accumulation. The subsequent analysis revealed a high diversity of prokaryotes in granular sludge, with the predominant archaea primarily involved in methane production through the acetic acid pathway. The IC anaerobic reactor shows exceptional performance in treating corn alcohol wastewater by optimizing its operating conditions. Energy balance analysis confirmed the feasibility of the process. The findings of this study may offer valuable insights for optimizing control strategies and engineering applications.
Ultraprecise weight feed at batching of nanopowder materials
Authors: Kai Jian Ding
Published: December 2023

In the article the current ways and the equipment for batching of powder шmaterials are considered. On the basis of an estimation of volume feeders accuracy authors revealed a necessity of use instead of them weight feeders: vibratory feeders or feeders of a suspension of powders in gas. There is perspective to use of feeders of suspensions of powders in gases for batching of ultra tiny portions of powders.
Reforming the pension system due to changes in life expectancy
Authors: Shermukhamedova Shirin Amonullaevna , Kuzieva Maftuna Khusenovna
Published: December 2023

This article discusses the impact of demographic aging of the population in developed countries on their economies. The coefficients for assessing the financial condition of the pension system are given. The level of participation of the population in pension provision is considered to assess the effectiveness and sustainability of the pension system. The contributions to pension insurance in the system of compulsory state insurance are analyzed.
Diagnóstico de infecção pelo HIV/aids entre adolescentes: reflexões sobre as intervenções de enfermagem
Authors: Octaviano Júnior Ademir , Menezes Jefferson Ubirajara de Moraes , Pena Larissa Elisa de Oliveira , Silva Suelem Regina da , Melo Laercio Deleon de , Taroco Felipe Eduardo
Published: December 2023

Introdução: objetivou-se refletir sobre as intervenções do enfermeiro frente a adolescentes com diagnóstico de infecções pelo HIV/Aids. Visando o alcance do objetivo proposto em resposta a questão de pesquisa, optou-se pela realização de um estudo descritivo, de cunho teórico reflexivo. Materiais e Métodos: foram pré-selecionados, 89 artigos, dos quais, na etapa de pré-seleção, foram excluídos 81 por não responderem às questões de investigação. Na etapa de seleção foram secionadas 26 obras, que foram lidos na íntegra por todos os autores em busca dos contributos de cada um deles a esta síntese reflexiva. Resultados e Discussões: a síntese do conhecimento científico foi organizada e apresentada sobre a forma de análise reflexiva na perspectiva da enfermagem em dois blocos temáticos, a saber: 1) Contextualização da Infecção pelo HIV/Aids entre adolescentes e seu processo de enfrentamento e; 2) Assistência integral de enfermagem a adolescentes: promoção da saúde, prevenção de infecções sexualmente transmissíveis e ações de cuidado frente à infecção por HIV/aids. Considerações Finais: o enfermeiro é essencial na execução de estratégias de diagnóstico precoce, prevenção e controle de infecções sexualmente transmissíveis a nível primário de saúde. Dentre as ações e intervenções de enfermagem cabe destacar o seu papel educativo e à necessidade de que este processo educativo seja inclusivo e inovador e atrativo aos adolescentes com a inclusão de tecnologias acessíveis a estes.
Palavras-Chave: Enfermagem em Saúde Pública; Adolescente; Infecções Sexualmente Transmissíveis; Infecções por HIV; Síndrome da Imunodeficiência Adquirida; Saúde Pública.
Metodologia ativa no ensino de enfermagem: relato de experiência, integração entre discentes ingressantes e concluintes
Authors: Loureiro Lucrécia Helena , Pinto Maria de Fátima da Rocha , Sepp Valquíria Jorge , Balbino Carlos Marcelo , Oliveira Aline Viviane  de
Published: December 2023

Objetivou-se relatar a experiência envolvendo alunos ingressantes e alunos concluintes em atividade interdisciplinar, utilizando o ambiente virtual de aprendizagem e a sala de aula tradicional, por meio da associação de metodologias ativas, ferramentas digitais, criatividade e trabalho em equipe. Este estudo tratou-se de um relato de experiência com a utilização de uma Metodologia Ativa de Ensino, desenvolvida em duas disciplinas de um curso de graduação em enfermagem de um Centro Universitário, a qual ocorreu em junho de 2022, em sala de aula em formato presencial, simultaneamente com os em outra sala de aula em formato remoto. Participaram das atividades docentes e discentes, que através de um torneio de jogos de perguntas e respostas utilizando metodologias ativas. Após a realização da atividade proposta o docente responsável que ministra as disciplinas relatou sua experiência e as impressões percebidas no transcorrer da aplicação da metodologia ativa, tendo seu relato transcrito, analisado e categorizado em etapas. Os resultados mostram o desenvolvimento de uma série de habilidades de comunicação, colaboração, pensamento crítico, criatividade, inovação, aprendizagem em pares e gamificação, nas quais os estudantes atuaram como agentes transformadores. Concluiu-se que estimular o raciocínio lógico, o pensamento crítico, a criatividade para a resolução de problemas com o manejo de novas tecnologias que requerem organização, concentração, significa desenvolver aprendizado participativo, comunicação e inteligência emocional.
Palavras-chave: Avaliação Educacional; Educação em Enfermagem; Métodos de Ensino; Ensino-Aprendizagem; Indústria 4.0.
Telessaúde no cuidado primário à saúde de ribeirinhos
Authors: Lima Ananda Miranda de , Faria Magda Guimarães de Araujo , Pacheco Fádia Carvalho
Published: December 2023

Objetivou-se identificar ações de telessaúde realizadas para efetivação do cuidado primário a saúde de população ribeirinha. Trata-se de revisão de escopo conduzida de acordo com as premissas do Joanna Briggs Institute e registrado no portal Open Science Framework. Definiu-se como questão de revisão: "Quais as ações de telessaúde são realizadas para efetivação do cuidado primário a saúde de população ribeirinha?" Os critérios de elegibilidade estão associados às publicações disponíveis para consulta na íntegra com abordagens metodológicas qualitativas, quantitativas, mistas, reflexões, editoriais, diretrizes, manuais e políticas. Não haverá restrições geográficas ou temporais. As buscas ocorrerão nas bases EMBASE, MEDLINE via PUBMED, Scopus, Web of Science e CINAHL e nos Portais: Periodicos CAPES e Regional da Biblioteca Virtual de Saúde. Os dados serão apresentados de forma descritiva e a primeira representação será por meio da utilização do fluxograma PRISMA. Posteriormente,  será apresentado quadro sinóptico com os principais achados. Espera-se que esta revisão consiga sumarizar as formas de influência da telessaude no atendimento à população ribeirinha, seja na assistência direta ou na melhora da resolubilidade das equipes de saúde. Acredita-se que esta análise poderá auxiliar a construção de ações mediadas por TICs e estimulará a criação de políticas públicas de saúde e educação.
Palavras-Chave: Atenção Primária a Saúde; População Ribeirinha; Telessaúde.
114 dias de UTI, 4 dias de Cuidados Paliativos: urge conversarmos sobre cuidado, vida e morte
Authors: Werner Suellen Vidal , Chagas Magda de Souza
Published: December 2023

Introdução: O Cuidado Paliativo (CP) é uma abordagem que visa atenuar as dores e melhorar a qualidade de vida, podendo e devendo ser ofertado desde o diagnóstico de uma doença crônica, configurando uma série de cuidados com o usuário-paciente/família, incluindo tratamentos para aliviar a dor, suporte emocional, assistência religiosa e acompanhamento psicológico. No tratamento paliativo significa ser cuidado de modo amplo/abrangente, com atenção aos aspectos físicos, emocionais e sociais. O objetivo desse artigo é relatar a experiência de acompanhar uma usuária/paciente durante os últimos 4(quatro) dias de vida, tendo a mesma permanecido internada na UTI durante 114 dias. Metodologia: Relato de experiência com uso de narrativas elaboradas a partir de vivência revisitada e as reflexões que surgiram no espaço de trabalho. O cenário foi uma UTI de um hospital público da região Serrana do Rio de Janeiro. Discussão: Sobre o momento para iniciar e fazer uso do CP, tendo como referência seus 4(quatro) pilares, que são: comunicação eficaz, controle dos sintomas, apoio à família e trabalho em equipe multidisciplinar. Assim como, melhorar a qualidade de vida, na sustentação da autonomia, manutenção da dignidade e o máximo de conforto possível. Considerações: a experiência resultou em reflexões sobre o tipo de cuidados ofertados e o que tem sido denominado CP. Na equipe multidisciplinar, resultou em rounds com discussões, questionamento sobre o tempo e o momento em que deve ser iniciado o CP ao longo das internações. Foi pactuado que usuários/pacientes em situações similares serão precocemente avaliados e a família incluída no processo.
Palavras-Chave: Cuidados Paliativos; Equipe Multiprofissional; Unidades de Terapia Intensiva; Narrativa.
Telemonitoramento neonatal, durante a internação e no pós alta: revisão integrativa
Authors: Uema Roberta Tognollo Borotta , Pereira Jennifer Martins , Santos Fernanda Pereira dos , Rodrigues Thamires Fernandes Cardoso da Silva , Ichisato Sueli Mutsumi Tsukuda , Radovanovic Cremilde Aparecida Trindade
Published: December 2023

Introdução: a prematuridade é um dos assuntos mais preocupantes dentro do contexto que envolve a saúde materno-infantil e a saúde pública. Considerando a fragilidade da população neonatal e o longo período de hospitalização logo após o nascimento, entende-se que o processo de alta neste contexto pode contar com ajuda de alguns instrumentos, dentre eles o telemonitoramento. Frente a isso, o estudo teve por objetivo identificar na literatura científica o uso do telemonitoramento como estratégia de cuidado durante à internação e após a alta hospitalar do neonato prematuro. Método: trata-se de uma revisão integrativa realizada utilizando-se a questão norteadora: Como o telemonitoramento é utilizado como estratégia de acompanhamento durante e após alta hospitalar do neonato prematuro? A coleta de dados ocorreu entre abril e julho de 2022 com os descritores: Telemonitoramento, Nascimento prematuro e Continuidade da Assistência ao Paciente, organizados pelo operador booleano AND nas bases de dados: Biblioteca Virtual em Saúde, Pubmed, Embase, Science Direct, Scopus e Web of Science. Resultados: do total de 1582 artigos 32 foram selecionados. Quatro foram excluídos por não estarem disponíveis na íntegra e 14 não respondiam a pergunta de pesquisa. A amostra final foi composta por 14 artigos que demonstraram que o telemonitoramento pode ser utilizado para fornecer informações durante a internação, e na alta hospitalar, é aplicado via telefônica, por e-mail e mensagens de aplicativo a fim de se tornar uma rede de apoio. Conclusão: o telemonitoramento no contexto neonatal pode ser uma estratégia de cuidado no ambiente hospitalar e no processo de alta. 
Palavras-chave: Telemonitoramento; Nascimento Prematuro; Revisão; Continuidade da Assistência ao Paciente.
Assistência Multidisciplinar ao pré-natal na atenção primária com acadêmicos de enfermagem, odontologia e medicina: relato de experiência
Authors: Vargas Fabiana Ramos , Silva Thiago Nogueira , Moccellin Marcia Cristina , Estrada Luciana Chagas Duque , Monteiro Samyama , Tavares Claudia Mara de Melo , Tavares Marilei de Melo
Published: December 2023

Introdução: Relatar a experiência de assistência multidisplicinar ao pré-natal na atenção primária com acadêmicos de enfermagem, odontologia e medicina por meio do processo de cuidado continuado. Materiais e Métodos: Trata-se de um estudo descritivo, com abordagem qualitativa, na modalidade de relato de experiência, proveniente da vivência em unidade de saúde da Atenção Primária a partir da análise sobre a assistência multiprofissional no pré-natal. Resultados: A experiência na assistência pré-natal aproxima as áreas de odontologia, medicina e enfermagem com a rotina de atendimento vivenciada na unidade por meio de uma rotatividade envolvendo preceptoria-ensino. Discussão: A garantia de atendimento com qualidade e o estabelecimento de vínculo entre a mulher, estudantes e profissionais de saúde são quesitos importantes para a humanização da assistência e favorecem a adesão e a permanência das gestantes no serviço de atenção ao pré-natal. Considerações Finais: Assim, é imprescindível e necessária a atuação multiprofissional na assistência pré-natal, ainda no âmbito da atenção primaria, com maior resolutividade, efetividade e humanização.

Palavras-Chave: Cuidado Pré-Natal; Atenção Primária à Saúde; Equipe de Saúde.
Setembro Amarelo: A campanha influencia no número de casos de auto-agressões no Rio de Janeiro?
Authors: Lopes Silva Yasmim , Avraham Ribas Laura , Rodrigues Neves Thaís , Bardela de Oliveira Julia , De Matos Costa de Menezes Manuela , Antonio Mendonça Marcos
Published: December 2023

Sendo uma das principais causas de morte entre jovens de 15 a 29 anos, o suicídio é um tema que vem ganhando cada vez mais atenção das instituições de ensino, dos agentes da saúde e da grande mídia. Ademais, a campanha Setembro Amarelo se populariza mais a cada ano, com a intenção de promover a conscientização sobre o tema e prevenção do suicídio. Portanto, com o intuito de analisar o impacto real que a campanha Setembro Amarelo obteve na comunidade, este estudo usou o Teste T de Student para comparar as médias mensais de notificações por lesões autoprovocadas no período de 2015 e 2020 no estado do Rio de Janeiro presentes no banco de dados do Departamento de Informática do Sistema Único de Saúde (DATASUS). Na análise do material foi observado que ocorreu uma diferença significativa entre a média de notificações no mês anterior ao início da ação pública em relação ao mês seguinte, que foi estatisticamente maior. O fato gera o questionamento sobre as informações compartilhadas na grande mídia durante o mês de setembro, mesmo que bem intencionadas, terem o efeito contrário ao desejado, aumentando o número de autoagressões. Com isso, ressalta-se a importância da reformulação das estratégias incorporadas por esta ação em saúde a fim de garantir o objetivo proposto e efetividade da campanha.
Sobrevida de pacientes com Carcinoma Colorretal e Metástase Peritoneal após Cirurgia Citorredutora associada à HIPEC.
Authors: Nogueira Sant'Ana Giovana , De Siqueira Braga Ariane Luiza , Alves Tostes Maria Cecília , Moreira Vieira Louise , Capute Neto Luiz
Published: December 2023

O câncer colorretal é o terceiro mais frequente em mulheres e o quarto em homens da população brasileira, além disso há tendência cada vez maior à mortalidade. Novos estudos mostram o aumento de sobrevida desses pacientes com quimioterapia intraperitoneal hipertérmica (HIPEC) em associação à cirurgia citorredutora. A base de dados consultada foi a National Library of Medicine – PubMed, com os descritores “Colorectal Neoplasms”, “Metastasis”, “Peritoneal Neoplasms”, “HIPEC” e “Survival”, utilizando o operador booleano “AND”. Foram incluídos artigos em inglês, com ensaios clínicos (“Clinical trial”), controlado e randomizado (“randomized controlled trial”), publicados nos últimos 10 anos. Após a avaliação dos critérios de inclusão e exclusão, mantiveram-se 6 artigos. A administração de medicações quimioterápicas via intraperitoneal hipertérmica mostrou impacto na continuidade do câncer colorretal, de suas complicações e metástases, sendo essa um recurso no tratamento quando há indicações. Todos os artigos analisados inseriram apenas àqueles com índice de carcinomatose peritoneal baixo ou moderado, a maioria apontou pequena melhora na taxa de sobrevida nos últimos 5 a 10 anos. A HIPEC gerou aumento na sobrevida dos pacientes portadores de Câncer Colorretal e metástase peritoneal. Porém, os dados para essa avaliação ainda são escassos, variáveis e incomparáveis, justificando a necessidade de maiores investigações em estudos prospectivos.

Palavras-chave: Neoplasias Colorretais; Metástase; Neoplasias Peritoneais; HIPEC; Sobrevida.
Antissépticos pré-operatórios na cirurgia cesariana nos últimos dez anos: uma revisão integrativa
Authors: Reis Pinheiro de Souza Eduardo , Da Silva de Castro Lucas , Kevin Soares de Lima Bruno , Drumond Guelber Arthur , Cristine de Almeida Costa Monique , Alexandre Terra Passos Márcio
Published: December 2023

A operação cesariana possui uma enorme importância na atualidade, mas, apesar dos grandes avanços científicos nos últimos dez anos, a incidência de infecção do sítio cirúrgico ainda preocupa a comunidade médica. Nesse sentido, destacam-se os estudos de assepsia no centro cirúrgico, em especial a antissepsia vaginal e os agentes químicos mais utilizados. Analisou-se de forma comparativa dados que abrangem tanto a eficácia quanto efeitos adversos dos principais antissépticos relativos a esse procedimento, principalmente a clorexidina e a iodo povidona. Dessa forma, foram pesquisados artigos no banco de dados do Pubmed com as seguintes diretrizes: “cesárea”, “antissépticos” e “infecções”. A pesquisa foi realizada com base em artigos publicados de 2014 até 2023 e, após os critérios de inclusão e exclusão, selecionaram-se 5 estudos. Ao avaliar o conjunto de informações relativas ao tema desta revisão, notou-se um ligeiro aumento na redução de infecções do sítio cirúrgico com a clorexidina, embora ainda seja discutível se tal valor tem importância clínica. Logo, levando em consideração a correta profilaxia antibiótica e o cumprimento adequado dos tempos cirúrgicos, o profissional de saúde tem papel fundamental na redução da taxa de infecções, endometrites ou febre pós-operatórias em gestantes. Por esse motivo, a comparação entre os meios antissépticos não deve se sobrepor a conduta ética do médico. 

Palavras-chave: cesárea; antissépticos; infecções.
Câncer de Cabeça e Pescoço:
Authors: Waskevicz Leticia , Waskevicz Camila , Americh Stering do Nascimento Victoria
Published: December 2023

O Câncer de Cabeça e Pescoço (CCP) que atinge o trato gastrointestinal superior, o qual os principais fatores de risco são o papilovírus humano (HPV), consumo de álcool e cigarro, além de questões genéticas. Essa doença pode afetar a saúde física, emocional e psicológica dos pacientes. Assim, o objetivo deste artigo é compilar e esclarecer aspectos sobre o diagnóstico e qualidade de vida referentes ao câncer de cabeça e pescoço. A metodologia é a revisão bibliográfica, qualitativa e descritiva da literatura, por meio de estudos localizados na Biblioteca Virtual em Saúde, em que foram selecionados 18 artigos. Dessa maneira, pode-se verificar que o controle dos fatores de risco é essencial para a minimizar os casos da doença, assim como o diagnóstico precoce é imprescindível para que o tratamento seja eficaz e o paciente tenha maior qualidade de vida.

 

Palavras-Chave: Detecção Precoce de Câncer; Neoplasias de Cabeça e Pescoço; Diagnóstico; Qualidade de Vida Relacionada à Saúde.