bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative chloroplast genome analysis of four Hippophae rhamnoides subspecies and its phylogenetic analysis
Authors: Wang Ruoqiong , Wang Xiangjie , Liu Zhihong , Han Youzhi , Xie Qing
Published: June 2023

Sea buckthorn(Hippophae rhamnoides), a hardy deciduous shrub of the family Elaeagnaceae, grows wild at high altitudes in Asia and Europe and is known for its great nutritional, medicinal and ecological value. In this study, the chloroplast genomesof four H. rhamnoidessubspecies, H. rhamnoides subsp. mongolica ‘wulanshalin’, H. rhamnoides subsp. caucasia, H. rhamnoides subsp. sinensis ‘wucixiong’, and H. rhamnoides subsp. yunnanensis, were characterized. The results showed that the genome length of these four subspecies ranged from 157,436 bp to 157,822 bp, with a typical quadripartite structure. Comparing the genome structure of these four subspecies, it was found that the chloroplast genomes were relatively conserved, retaining the same gene order. The annotation contained a total of 132 genes in each chloroplast genomes genome, with 86 protein-coding genes, 38 tRNA genes, and 8 rRNA genes. This study identified 14 highly differentiated regions and 423 simple sequence repeats loci, which can be used as potential molecular markers for H. rhamnoides. Meanwhile, Phylogenetic analysis showed that all Hippophae taxa were clustered in the same group and formed a sister clade with Elaeagnus taxa supported by Bayesian posterior probabilities. Among Hippophae taxa, H. gyantsensis, H. neurcar and H. salicifolia were grouped together, but H. tibetana was clustered with H. rhamnoide and the other six H. rhamnoide subspecies. The findings of this research will be useful for further studies on resource protection and the taxonomic classification of sea buckthorn.
Design of a Compound Reconfigurable Terahertz Antenna based on Graphene
Authors: Jin Zhao , Rong Yu , Yu JingDong , Wu Fei
Published: June 2023

In this paper, a terahertz dipole antenna with compound reconfigurability is designed, which possesses the capability of controlling frequency, radiation pattern, and polarization state. A capacitive load loop (CLL) made of graphene-metal composite material is applied around a pair of mutually orthogonal graphene-based dipole antennas. By controlling the bias voltage, the surface conductivity of graphene is adjusted, enabling compound reconfigurability. The graphene strips on the CLL provide a high degree of freedom for the radiation characteristics of the antenna. By adjusting the combination of chemical potentials of graphene, the operating frequency of the antenna can be reconfigured within the range of 1.40 THz to 1.84 THz. Moreover, it is possible to control the antenna to achieve directional radiation with four beams (0°, 90°, 180°, 270°) in the XOY plane at 1.75 THz, and ranging from 1.68 THz to 1.81 THz, it can be reconfigured to achieve controllable RHCL or LHCL.
Central projections from Johnston´s Organ in the locust: axogenesis and brain neuroarchitecture
Authors: Boyan George , Williams Leslie , Ehrhardt Erica
Published: June 2023

Johnston´s Organ (JO) acts as an antennal auditory organ across a spectrum of insect species and its axons universally project to the brain. In the locust, this pathway is present at mid-embryogenesis but the process of fasciculation involved in constructing it has not been investigated. Terminal projections into the fine neuropilar organisation of the brain also remain unresolved, information essential for providing insights into the neural circuitry mediating JO-mediated behavior and its evolutionary aspects. In our study here, we employ both neuron-specific and axon-specific labels to show that the pathway to the brain of the locust is built in a stepwise manner during early embryogenesis as processes from JO cell clusters fasciculate first with one another, and then with the two tracts constituting the pioneer axon scaffold of the antenna. A comparison of fasciculation patterns confirms that projections from cell clusters of the JO stereotypically associate with only one axon tract according to their location in the pedicel, consistent with a topographic plan. At the molecular level, all neuronal elements of the JO pathway to the brain express the lipocalin Lazarillo, a cell surface epitope we have shown regulates axogenesis in the primary axon scaffold and may also do so during fasciculation of JO projections to the brain. Central projections from JO first contact the primary axon scaffold of the mid-embryonic brain in the mechanosensory region of the antennal lobe but terminate in the protocerebrum. Examination of the neuroarchitecture of the adult brain reveals these terminals lie among the processes of premotor interneurons known to regulate flight behavior.
European and American Grapevines were Successfully Recovered from GFkV and GLRaV-1,2,3 Viruses by a Modified Thermotherapy and Shoot Tip Culture
Authors: SAĞLAM Hayri , SAĞLAM Özlem ÇALKAN , GÜLER Emrah , AKBAŞ Birol , GÜNER Üftade
Published: June 2023

The purpose of this study was to look into the use of thermotherapy and shoot tip culture to disinfect grapevines from Grapevine fanleaf nepovirus (GFLV), Grapevine fleck virus (GFkV), and Grapevine leafroll closterovirus (GLRaV) -1,-2,-3, all of which are required for certified sapling production. The GFkV, GLRaV-1,2,3-infected grapevine scions were taken from the initial testing and put into 10-liter plastic containers. They were rooted, and saplings were grown from them. The grapevines were then treated to a modified thermotherapy treatment for 40 days, which included 8 hours of darkness at 60–70% relative humidity and 32°C temperature and 16 hours of light (4000–5000 lux) at 60–70% relative humidity and 40°C temperature. The experimental materials were treated to shoot tip culture procedures after thermotherapy. At the end of the acclimation, all materials were tested again. At the conclusion of the testing procedures, the entire factory was virus-free. The survival rates of the grapevines differed, with 41B rootstock having a 100% survival rate and the rest having at least one survived plant out of six. When paired with rapid multiplication through in-vitro propagation, the proposed thermotherapy approach used in this study has a high potential for virus-free grapevine sapling propagation.
Disabled-2: a protein up-regulated by high molecular weight hyaluronan has both tumor suppressor and tumor promoting roles in ovarian cancer
Authors: Price Zoe K , Lokman Noor A , Sugiyama Mai , Koya Yoshihiro , Yoshihara Masato , Oehler Martin K , Kajiyama Hiroaki , Ricciardelli Carmela
Published: June 2023

Objective: Although the pro-tumorigenic functions of hyaluronan (HA) are well documented in ovarian cancer, there is limited information on the effects of different molecular weight HA. The aim of this study was to analyse the effects of different molecular weight HA on ovarian cancer cells overexpressing Notch3 intracellular domain (NICD3, stem cell associated protein).
Methods: Mass spectrometry analysis of spheroids from ES-2 cells overexpressing NICD3 (ES-2-Rv-NICD3) with wild type ES-2 (ES-2:ES-2-Rv-NICD3, 1:3) treated with 27kDa, 183kDa or 1000kDa HA identified a novel protein regulated by high molecular weight HA (HMW-HA), disabled-2 (DAB2). Correlations between DAB2 and patient prognosis and pro-tumorigenic signatures were assessed in online databases. DAB2 was assessed by immunohistochemistry in a tissue microarray cohort of high grade serous ovarian carcinoma (HGSOC) and matching tissues following relapse. Gain-of-function lentiviral methods were employed in A2780 and OVCAR3 ovarian cancer cells to determine the effect of DAB2 on cell survival, spheroid formation, gene expression, cell motility and invasion in vitro and in vivousing the chick chorioallantoic membrane (CAM) assay.
Results: HMW-HA (1000kDa) enhanced spheroid formation of ES-2:ES-2-Rv-NICD3 cells. Mass spectrometry identified DAB2 was upregulated 5.2 fold in HMW-HA treated ES-2:ES-2-Rv-NICD3 spheroids. Online database analysis showed DAB2 was downregulated in ovarian cancer compared to normal ovarian tissue but increased in metastatic compared to primary ovarian tumors. High DAB2 expression was associated with poor patient outcome and positively correlated with EMT markers. Stromal DAB2 immunostaining was significantly increased in matched tissues at relapse compared to diagnosis and associated with reduced survival. Furthermore, DAB2 protein co-localised with macrophage marker (CD68) in HGSOC tissues. In OVCAR3 but not A2780 cells, DAB2 overexpression enhanced carboplatin resistance and reduced cell motility and invasion in vitro. DAB2 overexpression reduced OVCAR3 and A2780 cell survival and in vivoinvasion in the CAM assay.
Conclusions: Our findings highlight that DAB2 has both tumor suppressive and pro-tumorigenic functions in ovarian cancer
Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving CAR T-cell therapy
Authors: Poutón Nicol García , Ortiz-Maldonado Valentín , Peyrony Oliver , Chumbita Mariana , Aiello Tommaso Francesco , Monzo Patricia , Lopera Carlos , Alcalde Pedro Puerta , Magnano Laura , Martinez-Cibrian Nuria , Pitart Cristina , Juan Manel , Delgado Julio , Larrea Carlos Fernández , Soriano Álex , Urbano-Ispizua Álvaro , Garcia-Vidal Carolina
Published: June 2023

Background: We described the real-life epidemiology and causes of infections on the different therapy phases in patients with haematological malignancies undergoing chimeric antigen receptor (CAR) T-cells directed towards CD19+ or BCMA+ cells.
Methods: All consecutive patients receiving CAR T-cell therapy at our institution were prospectively followed-up. We performed various comparative analyses of all patients and subgroups with and without infections.
Results: 91 adults mainly received CAR T-cell therapy for acute leukemia (53%) and lymphoma (33%). We documented a total of 77 infections in 47 (52%) patients, 37 (48%) during the initial neutropenic phase and 40 (52%) during the non-neutropenic phase. Infections during the neutropenic phase were mainly due to bacterial (29, 78%): catheter infections (11 [38%] cases), endogenous source (5 [17%]), and Clostridiodes difficile (5 [17%]). Viral and fungal infections accounted for 14% and 8% of infections. Those patients receiving corticosteroids after CAR T-cell therapy had a higher risk of endogenous infection (100% vs 16%; p=0.006). During the non-neutropenic phase, bacterial infections remained very frequent (24, 60%), mainly with catheter source (8, 33%). Respiratory tract infections were common (17, 43%), frequently caused by viruses (14, 82%). There were no documented differences in patients with and without infections in this phase.
Conclusions: Infections after CAR T-cell therapy were frequent. During the neutropenic phase, it is essential to prevent nosocomial infections and balance the use of antibiotics to lower endogenous bacteraemia and Clostridial infection rates. It is also mandatory to improve preventive strategies for viral respiratory tract infections in later therapy phases.
Image encryption system based on a novel simultaneous permutation and diffusion framework utilizing modified Josephus traversing
Authors: Le Zhen , Chen Huang , Cai Shuting , Xiong Xiaoming , Huang Linqing
Published: June 2023

This paper proposes a novel image encryption system based on a new simultaneous permutation and diffusion framework utilizing modified Josephus traversing (SPDMJT). Firstly, SPDMJT utilizes the reverse scanning method to perform encryption process, guaranteeing the ergodicity of scrambling. Secondly, the diffusion is embedded into the Josephus traversing, preventing attackers from targeting the scrambling and diffusion phases separately. Thirdly, in order to enhance permutation effect, modified Josephus traversing employs a dynamic scrambling method where the scrambling scheme of the current pixel depends on the value of the previous diffused pixel. Moreover, SPDMJT adopts plaintext correlation both in scrambling and diffusion operation, which strikes a balance between ciphertext sensitivity and plaintext sensitivity, offering resistance against chosen-plaintext attacks (CPA), noise attacks and data loss. Simulation results show that the proposed algorithm has high encryption efficiency and can withstand various common attacks.
Emotional Eating – Elusive or Evident? Integrating Laboratory, Psychometric and Daily Life Measures
Authors: Schnepper Rebekka , Blechert Jens , Arend Ann-Kathrin , Yanagida Takuya , Reichenberger Julia
Published: June 2023

Purpose: Emotional eating (EE) refers to eating in response to (negative) emotions. Evidence for the validity of EE is mixed: some meta-analyses find EE only in eating disordered patients, others only in restrained eaters, which suggest that only certain subgroups show EE. Furthermore, EE measures from lab-based assessments, ecological momentary assessment (EMA), and psychometric measures often diverge. This paper tested whether the covariance of these three different EE methods can be modeled through a single latent variable (factorial validity), and if so, how this variable would relate to restrained eating (construct validity), Body-Mass-Index (BMI), and subclinical eating disorder symptomatology (concurrent validity).
Methods: 102 non-eating disordered female participants with a wide BMI range completed EE measures from three methods: psychometric questionnaires, a laboratory experiment (craving ratings of food images in induced neutral vs. negative emotion) and EMA-questionnaires (within-participant correlations of momentary negative emotions and momentary food cravings across nine days). Two measures for each method were extracted and submitted to confirmatory factor analysis.
Results: A one-factor model provided a good fit. The resulting EElat factor correlated positively with subclinical eating disorder symptoms and BMI but not with restrained eating.
Conclusion: The one-factor solution shows that the EE construct can validly be assessed with three different methods. Individual differences in EE are supported by the data and are related to eating and weight problem symptomatology but not to restrained eating. This supports learning accounts of EE and underscores the relevance of the EE construct to physical and mental health.
Counting algorithms with phase sensitive detection for hover and S turn of aircraft flight
Authors: Chen Moli , Wei Xunkai , Wang Hao , Jiang Zhenhe
Published: June 2023

Hover and S turn of an aircraft can be characterized by flight yaw angle, but the yaw angle signal in actual fly parameters is not only non-stationary and non- ergodic, but also often appears violent mutations and weak fluctuations, which makes it difficult to work out service environment spectra related to the numbers of hovering and S-turning training times. This article develops intelligent counting algorithms for the numbers of hovers and S turns based on yaw angle data that from fly parameters. Using the median-crossing de redundant function of Phase Sensitive Detection (PSD) and analyzing the characteristics of 360° hovering fly parameters, a counting algorithm for the number of hovers during a flight profile is presented. Using the split-half function of PSD, a triangle layering algorithm about yaw angle signal is developed to count the number of S turns during a flight profile, where the signal of each sublayer is segmented into the median-crossing intervals so as to eliminate the redundant median-crossing marks from the previous layer. Compared with the artificial means, the counting results of flight example show that the intelligent algorithms presented are effective.
Multicenter preclinical analysis of tenecteplase versus alteplase
Authors: Correa-Paz Clara , Pérez-Mato María , Bellemain-Sagnard Mathys , González-Domínguez Marco , Marie Pauline , Pérez-Gayol Lara , López-Arias Esteban , Pozo-Filíu Lucia , López-Amoedo Sonia , Bugallo-Casal Ana , Alonso-Alonso Mª Luz , Candamo-Lourido María , Santamaría-Cadavid María , Arias-Rivas Susana , Rodríguez-Yañez Manuel , Iglesias-Rey Ramón , Castillo José , Vivien Denis , Rubio Marina , Campos Francisco
Published: June 2023

Recombinant tissue plasminogen activator (rtPA/Alteplase) remains the gold standard thrombolytic drug for acute ischemic stroke. However, new rtPA-derived molecules such as Tenecteplase (TNK) with longer plasmatic half-life, practical delivery advantages as a fast, single bolus and increased fibrin binding have been developed. In spite of the recommendations on the bi-directionality of the basic/clinical research relationship, TNK is being tested in clinical trials without a preclinical basis on its toxicity and efficacy. In this study, toxicities of rtPA and TNK were evaluated on endothelial, astrocytes and neuronal culture; and efficacy was independently tested by two research centres in a thromboembolic model of ischemic stroke in mice. Both therapies were tested after early (20 and 30 min) and late administration (4 and 4.5 h) of ischemia onset. rtPA and TNK did not affect the viability of the endothelial cells or astrocytes. In neuronal cultures, rtPA, but not TNK, increased cell death at 24 h by itself. A single bolus dose of TNK showed an infarct volume reduction similar to that obtained after the perfusion of rtPA. TNK has a therapeutic window similar to rtPA and loses its beneficial effect when administered late. Early administration of TNK decreases the risk of haemorrhagic transformations compared to rtPA, but not when it is administered as a late treatment. These two independent preclinical studies support the use of TNK as a promising reperfusion alternative to rtPA treatment, mainly due to lower neurotoxicity and risk of haemorrhagic transformation when administered early after stroke onset.
Answer Me: Pictorial Interrogation on Categorized Queries
Authors: Shahapure Nagamani , V Sahana , M Rekha P
Published: June 2023

The recent years have witnessed massive development in the fields of computer vision, object recognition, and natural language processing (NLP). Artificial Intelligence (AI) applications use NLP to provide the computer with facilities, such as question-answering models. An extension of this method is to integrate NLP with computer vision to perform the Visual Question Answering (VQA) mission, which is to construct systems that can respond to image questions in natural language. In this paper, the application of Convolutional Neural Network (CNN) for the image Question Answering (QA) task is proposed. The proposed CNN provides an end-to-end framework with convolutional architectures for learning not only the image and question representations, but also their inter-modal interactions to produce the answer. More specifically, this model consists of three CNNs: image CNN to encode the image content, sentence CNN to compose the words of the question, and multimodal convolution layer to learn their joint representation for the classification in the space of candidate answer words.
Lagrange radial basis functions collocation method for boundary value problems in 1D
Authors: Arfaj Kawther Al , Levesly Jeremy
Published: June 2023

This paper introduces the Lagrange collocation method with radial basis functions (LRBF) as a novel approach for solving 1D partial differential equations. Our method addresses the trade-off principle, a key challenge in standard RBF collocation methods, by maintaining the accuracy and convergence of the numerical solution while improving stability and efficiency. We prove the existence and uniqueness of the numerical solution for specific differential operators, such as the Laplacian operator, and for positive definite RBFs. Additionally, we introduce a perturbation to the main matrix, developing the perturbed LRBF method (PLRBF) which allows for the application of Cholesky decomposition, significantly reducing the condition number of the matrix to its square root, resulting in the CPLRBF method. In return, this enables us to choose a large value for the shape parameter without compromising stability and accuracy, provided the perturbation is carefully selected. By doing so, highly accurate solutions can be achieved at an early level, significantly reducing CPU time. Furthermore, to overcome stagnation issues in the RBF collocation method, we combine LRBF and CPLRBF with multilevel techniques and get the Multilevel PLRBF (MuC-PLRBF). We illustrate the stability, accuracy, convergence, and efficiency of the presented methods in numerical experiments with a 1D Poisson equation. Although our approach is presented for 1D, we expect to extend it to higher dimensions in future work.
The Effect of Congruent Tibial Inserts in Total Knee Arthroplasty: A Network Meta- analysis of Randomized Controlled Trials
Authors: Tsai Yen-Lin , Tsai Sung Huang Laurent , Lin Chia-Han , Lin Chun-Ru , Hu Chih-Chien
Published: June 2023

Objective
This study aims to determine whether modern ultracongruent tibial inserts are associated with different outcomes in Total Knee Arthroplasty (TKA).
Background
Ultracongruent fixed-bearing (UCFB) and medial congruent fixed-bearing (MCFB) inserts have been known to be effective in total knee arthroplasty with patient satisfaction. Nonetheless, no supporting evidence to date exists to rank the clinical outcomes of these various congruent inserts in TKA.
Methods
We searched for PubMed, Embase, The Cochrane Central Register of Controlled Trials, Web of Science, and Scopus up to May 15, 2022. We selected studies involving an active comparison of UCFB or MCFB in TKAs. We performed a network meta-analysis (NMA) of randomized controlled trials (RCTs) and compared different congruent inserts. We ranked the clinical outcomes by SUCRA score with the estimate of the best treatment probability. Our primary outcomes were revision rates and radiolucent lines. Secondary outcomes were functional scores, including the range of motion (ROM), the Knee Society Score (KSS), Oxford Knee Score (OKS), and WOMAC.
Results
18 RCTs with 1793 participants were obtained. The MCFB performed similar revision rates as CRFB and PSRP. CRFB and UCFB had the lowest radiolucent lines. UCFB and MCFB had the best OKS score overall.
Conclusions
The ranking probability for better clinical outcomes in congruent inserts demonstrated the superiority of congruent tibial inserts, including UCFB and MCFB. UCFB may be associated with improved postoperative functional outcomes. However, integrating future RCTs for high-level evidence is necessary to confirm these findings.
Inversion of Rayleigh Wave Dispersion Curves Via BP Neural Network and PSO
Authors: Luo Yijian
Published: June 2023

Rayleigh wave is widely applied in engineering exploration and geotectonic research. While how to reconstruct the corresponding geological information via Rayleigh wave is the critical process and difficulty. This paper presents an inversion method of Rayleigh wave dispersion curves based on BP neural network and PSO. In this work, a sample set that referring to the actual stratum distribution is firstly generated. Then, BP neural network is adopted to train the nonlinear mapping relationship between the dispersion curves and the shear wave velocity of each stratum. The trained BP neural network can quickly output a predicted value with rationality but poor precision, which can be utilized as the initial model of PSO inversion. PSO will then be adopted to further optimize the inversion result on the basis of BP neural network prediction. The combination of BP neural network and PSO aims at overcoming the defects of BP neural network that unable to carry out continual optimization and the slow optimization of PSO in the absence of reasonable initial solution. Finally, the effectiveness of the proposed algorithm is verified by a series of synthetic models and an active-source Rayleigh wave experiment carried out in a new railway project from Baotou, Inner Mongolia to Yinchuan, Ningxia.
Impact of vaccination strategies on the spread of COVID-19 pandemics: A mathematical modelling approach
Authors: Khoshnaw Sarbaz H. A. , Abdulrahman Kawther Yusuf , Mustafa Arkan N.
Published: June 2023

Mathematical models with computational simulations are useful tools for analyzing the spread and control of COVID-19 disease. In this study, we develop the previous models of COVID-19 pandemics. The vaccination compartment and its reaction rates are considered. Some key computational simulations and sensitivity analysis are applied on the model. Accordingly, three techniques of sensitivity analysis are discussed to compute the local sensitivities between model states and parameters. In addition, the basic reproduction number 𝑅0 is calculated for the model equilibrium points. The elasticity between the basic reproduction number, and the model parameters is also calculated. Furthermore, the daily real data of vaccinated cases in the United Kingdom from 15th March, 2021 to 31st December, 2021 are used. Results based on sensitivity analysis show that vaccination rate, contact tracing, rapid testing are the most important parameters to reduce the basic reproduction number. This helps international efforts to reduce the number of infected individuals from the disease. Another novelty in this work is that there is a good fit between the real data and model results. The model results will provide further control strategies and help local efforts to control this disease more effectively widely.
Survival benefit for HPV+ OPSCC patients with dominant serum IgA over IgG antibodies against HPV16 L1
Authors: Weiland Thomas , Zgubic Jakob , Brcic Luka , Thurnher Dietmar
Published: June 2023

Background
Although the therapy response of HPV-positive oropharyngeal carcinomas (OPSCC) is known to be significantly better compared to HPV-negative tumors, about 25% of them will have a recurrence within the first 5 years after therapy. Therefore, it is of great scientific interest to find relevant biomarkers to identify subgroups with a poorer prognosis. In this prospective observational study, we examine for the first time the behavior of HPV-L1 antibody subclasses IgA, IgG, and IgM in HPV-positive OPSCC patients under therapy.
Material and Methods
The study cohort included patients with HPV-positive OPSCCs from the Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz. Serum samples were collected before and during tumor-specific therapy and follow-up. They were analyzed for the presence of HPV-L1 antibody (AB) subclasses IgA, IgM, and IgG using an HPV-L1-specific immuno-assay. In addition, a PCR-based HPV-DNA detection and subtyping from the tumor tissue was performed. Statistical analysis included Chi2- and Kruskal-Wallis-H-Test for significance testing. Correlation between two ordinal sizes has been tested using Spearmen-Rho.
Results
Altogether, 34 patients with a mean age of 63.5 years and a mean follow-up of 55 months were included. The most common L1-AB-subclass pattern was characterized by IgG > > IgA > IgM (13 cases) without significant fluctuation. The second most common pattern was IgG > IgA > IgM (6 cases). In 5 cases an antibody pattern of IgA > IgG > IgM while in 4 cases IgG = IgA > IgM was seen. Three out of 4 recurrences had previously shown an increase in IgG antibodies. Patients with excessive IgG levels tended to have higher tumor stages. IgA dominance at diagnosis was associated with better disease-free survival.
Conclusions
In this prospective longitudinal observational study, we show for the first time the behavior of HPV-L1 antibody subclasses IgA, IgG, and IGM in HPV-positive OPSCC patients under therapy. IgA dominance at diagnosis was associated with better disease-free survival, whereas a higher IgG/IgA ratio correlated with higher tumor stages. In three recurrent tumors, an increase in the IgG AB level could be shown beforehand. HPV-L1 AB-subclass detection might be of use for future risk stratification in HPV-pos. OPSCC patients.
Smart Anonymity: A Mechanism for Recommending Data Anonymization Algorithms Based on Data Profiles for IoT Environments.
Authors: Neves Flavio , Souza Rafael , Lima Wesley , Raul Wellison , Bonfim Michel , Garcia Vinicius
Published: June 2023

The Internet of Things (IoT) has grown rapidly in recent years. However, coupled with a large number of devices and the huge volume of data generated by these devices, an impasse arises: the privacy of the data of IoT device users. The goal of this research is to propose a solution that recommends which data anonymization algorithm is the most suitable for the dataset according to its characteristics. Among the contributions of this research, we can highlight the creation of metrics for classifying IoT data. Using the metrics to create two Ontologies that use Description Logic for classification of IoT data. The use of Description Logic brings as positive points the verification of inconsistency and discovery of new facts to validate data. The evaluation results demonstrate that the use of the proposed approach brings benefits for user privacy.
Detect Melanoma Skin Cancer Using An Improved Deep Learning CNN Model With Improved Computational Costs
Authors: Ganesh Gourav Ganesh , Somasundaram K Somasundaram
Published: June 2023

Melanoma cancer has been considered as one of the most deadliest cancer. Melanoma is a highly malignant form of skin cancer that originates from melanocytes, the cells responsible for producing skin pigment. It is characterized by the uncontrolled proliferation of abnormal cells, which have the potential to invade surrounding tissues and spread to distant parts of the body. In this work, we aim to classify the skin disease into 7 classes. Our objective is to propose a deep learning CNN model to improve the accuracy of melanoma detection by customizing the number of layers in the network architecture and activation functions followed by reducing the computational cost. A comparitive study is made between the improved model and the use of pre-trained Models like Resnet, DenseNet, Inception, VGG and DenseNet-II which has been giving impeccable accuracy. The HAM10000 dataset is used for research and we have got better results for the proposed model. Also, graphical results have been obtained for the same.
Identifying Cuproptosis-Related Hub Genes and Their Clinical Significance in Tumors
Authors: Gao Hui , Lv Liqiong , Lan YanDan
Published: June 2023

The freshly detected Cuproptosis is a novel form of tumor cell death whose role in pan-cancer is still not completely unintelligible. Methods: We analyzed and assessed the Cuproptosis-related genes (FDX1, LIPT1, DLD, LIAS, DLAT, PDHA1, PDHB, MTF1, GLS and CDKN2A) conversion through the STING database and Sytoscpy software, performed functional enrichment analysis and identified the Hub genes. We extracted the expression data of Hub gene in tumor through TGCA and UCSC database, and analyzed its clinical prognosis. The cancer single-cell state atlas (CSEA) database was used to evaluate the effect of Hub genes on tumor phenotype in single cell lines. Finally, we analyzed the Hub genes mutation and evaluated its correlation with tumor immune infiltration. Results: DLD and LIAS were identified as the Hub genes of Cuproptosis, which have the same CCM score. Mutation analysis revealed that the expression of Hub genes is steady in pan-cancer, DLD and LIAS have been identified as tumor suppressor genes or oncogenes in different tumors. ROC curve analysis showed that DLD and LIAS had a very high predictive effect on survival and prognosis in LAML, and DLD also had a very high predictive effect in the other 4 tumor types. Through the expression of Hub gene in single cell lines, we found that DLD and LIAS displayed significant inhibitory and facilitative effects in different phenotypes of different tumors. Lastly, we explored the relationship between Hub genes and immune infiltration, and found that DLD was substantially associated with immune infiltration of 23 different tumors, and LIAS was significantly associated with immune infiltration of 31 different tumors. Conclusion: We preliminarily evaluated the effect of Cuproptosis on pan-cancer through the hub gene of Cuproptosis, suggesting that copper death has different effects in different tumors.
Investigating impostorism among undergraduate medical students at Sultan Qaboos University: a questionnaire-based study
Authors: Lawati Abdullah Al , Wahaibi Anas Al , Kharusi Fatma Al , Chan Moon Fai , Sinawi Hamed Al
Published: June 2023

Background:
Imposter syndrome (IS) is a psychological pattern where successful individuals fail to recognize their achievements and often attribute them to good luck and timing. The presence of Imposter syndrome among medical students is gaining more attention, with studies reporting a strong association with burnout phenomenon, anxiety, and depression.
Objectives:
This study sought to determine the prevalence of IS among Omani medical students and classify the levels of severity among the sample.
Methodology:
This was a cross-sectional, observational study conducted at a public university in Muscat, Oman. The Clance Impostor Phenomenon Scale (CIPS), a validated publicly available questionnaire, was used to determine whether students exhibited impostorism and, if so, its severity. Students who scored 63 or higher in the CIPS were classified as impostors.
Results:
A total of 276 students participated (M 34%, F 66%), of which 144 (52.2%) were found to have Impostor Syndrome with 12.7% exhibiting severe impostorism.
Conclusion:
The results show that IS present in significant frequencies among medical students; further studies are needed to address this problem.
Rhizome Segments Form Shoots, Whereas Leaf Cuttings Form Shoots and Rhizomes in Eucodonia ‘Adele’ Treated with Benzyladenine
Authors: Geneve Robert L. , Dutton Shari , Baloh Anna G. , Nosarzewski Marta
Published: June 2023

Eucodonia ‘Adele’ initiates seasonal shoot growth from a scaly rhizome. Larger rhizome segments (>2.5 cm) produced shoots at a greater percentage compared with smaller rhizome segments. Shoots produced on larger segments were initiated sooner and had a longer length. However, when shoot formation efficiency was calculated as the number of potential shoots per original stock rhizome, smaller rhizome segments were more efficient, producing three to four times as many shoots. Rhizome segments (2.5 cm) soaked overnight in benzyladenine (BA) produced three to four times more shoots per rhizome (four shoots) compared with untreated or water-soaked rhizomes (0.3 and 0.7 shoot, respectively). The scaly rhizome consists of a central stem-like core surrounded by numerous leaf-like scales. Scales appear to be storage leaf tissue based on anatomy and presence of numerous amyloplasts. New shoots initiate as axillary shoots formed from the central core at the scale attachment. Isolated individual scales also have the capacity for adventitious shoot formation, but only form in about 25% of isolated scales. Leaf cuttings were capable of producing adventitious shoots, roots, and rhizomes. Untreated petiole and lamina cut leaf cuttings formed approximately three rhizomes per leaf cutting compared with less than one adventitious shoot per leaf cutting. Benzyladenine-treated leaf cuttings did not show an increase in rhizome initiation, but soaking lamina cut leaf cuttings in water or BA increased shoot formation to ∼1.5 shoots per cutting. This work with isolated rhizome segments and leaf cuttings presents efficient systems for regenerating rhizomes that can be used to produce stock plants for a stem cutting system for Eucodonia ‘Adele’ as a seasonal pot plant.
The use of stem cells and 3D bioprinting of pancreatic islets in the treatment of type 1 diabetes mellitus: history and perspectives
Authors: Bulgakova S. V. , Dolgikh Y. A. , Treneva E. V. , Sharonova L. A. , Kosareva O. V. , Kurmaev D. P.
Published: June 2023

Type 1 diabetes mellitus (DM) is a disease characterized by hyperglycemia due to an absolute insulin deficiency caused by autoimmune destruction of insulin-producing β-cells. The disease occurs at a young age, is characterized by a labile course, a tendency to ketoacidosis and leads to the development of vascular complications that contribute to disability and early death of patients. To date, insulin therapy is the only treatment for type 1 diabetes. However, this method of treatment is not perfect. Patients need to adjust their diet, conduct frequent glycemic control and multiple injections of insulin. In this regard, the search for more effective methods of treating type 1 diabetes continues. The transformation of stem cells as a potential source of αand β-cells and their transplantation to the patient seems promising. However, it is not enough to simply obtain α- and β-cells from any stem cell. An important role is played by the interaction between the cells of the pancreatic islets. Currently, attempts are being made to develop functional in vitro models of pancreatic islets in which the cellular microenvironment would be completely preserved. The possibility of culturing and monitoring cells in a permeable three-dimensional microenvironment has been demonstrated. Combining different types of cells with each other in biologically suitable protein hydrogels allows the formation of spatial tissue systems. Cell microvascularization is also important, which is critical for adequate glucose homeostasis. 3D bioprinting can help ensure proper cell distribution in the scaffold and help reduce hypoxia through vascularization. 3D bioprinting technology will solve the  problems of  creating a  natural environment for  pancreatic islets with extracellular matrix and vasculature, since this technology will help to create organs in fully controlled conditions in vitro. However, this technology is still developing and further research is required in this direction.
Impact of Conservation Processes on the Lipid Profile and Immunological Factors IL-10 and TGF-β1 in Whey Separated from Discarded Human Milk
Authors: Alves Eloize , Castro Matheus , Saqueti Bruno , Manin Luciana , Alencar Josiane , Zacarias Joana , Bruni Andressa , Madrona Grasiele , Visentainer Jeane , Cristianini Marcelo , Santos Oscar , Visentainer Jesui
Published: June 2023

Reuse made by the separation of whey can reduce the waste of human milk. However, the authors are not aware of the literature on treatments in human whey, made available by pasteurization holder, freeze-drying, spray drying, and high hydrostatic pressure. In this context, the present study applied treatments to human whey and evaluated their lipid and immunological quality. Among the results, a different formation in the triacylglycerol profile was evidenced after the application of spray drying and high hydrostatic pressure, while pasteurization and freezedrying presented ion intensity close to the control human whey. In addition, pasteurization proved to be adequate for lipid nutritional quality and transformation factor-β1 (TGF-β1) concentration, while an increase in interleukin-10 (IL-10) levels was promoted, between 73 and 80%, after freeze-drying, spray drying, and high hydrostatic pressure. Through the principal component analysis, it is noteworthy that the processes presented divergences in terms of the effects caused, with similarity only between pasteurization and freeze-drying in the composition of fatty acids. However, it was observed that all processes were able to maintain the nutrients. Nevertheless, it is relevant to consider individual characteristics presented and the interest in the desired quality, which can be promising as a complementary product to infant feeding.
Herbal Medicines - A Fruitful Approach to Periodic Illness
Dysmenorrhoea: Evidence-based Review
Authors: Bansal Keshav , Sharma Sachin , Bajpai Meenakshi
Published: June 2023

Dysmenorrhea (menstrual or periodic pain) is a discomfort that occurs during painful
periods. It is the first and most prominent reason for female lower abdominal pain. Most adolescent
girls consider it a curse due to the periodic occurrence of painful cramps and bleeding. The
pathogenesis of painful periods is most likely because of increased prostanoids, notably prostaglandins,
produced by the cyclooxygenase pathway (PGs). Misuse of synthetic medications leads
to the development of medication resistance and deposits toxic residues in the body; thus, there is
a critical need for safe and effective alternatives. In recent decades, herbal treatment approaches
have found extensive applications in the treatment of various ailments. Herbal therapies are an
alternate source, which include several bioactive chemicals, and recent improvements in our understanding
of the value of herbal therapy methods have caused a sharp rise in their production.
The main focus of this review was to study herbal treatment options; the recent studies conducted
on herbal therapies and various experimental investigations on dysmenorrhea and herbal therapy
methods have been studied, and randomized controlled trials and animal models have been discussed
describing the anti-inflammatory properties of some potential herbal medicines that can be
used as treatment options for dysmenorrhoea. This review aimed to present herbal treatments that
can be used as alternative traditional synthetic medications and oral hormonal contraceptives in the
treatment of painful menstruation.
Conclusion and Future Scope
Authors: Dhaliwal Balwinder S. , Pattnaik Suman , Pattnaik Shyam Sundar
Published: June 2023

The conclusion drawn from the research work presented in the book, with
some recommendations for future work, is presented in this chapter. 
Research and development of a standardized STEM classroom operation process with integrated smart technologies to meet the requirements of the 2018 general education program in Vietnam
Authors: Thuy Le Thi Ngoc , Tinh Tran Trung , Yen Nguyen Thi Hai , Trang Nguyen Thi Huyen
Published: June 2023

The article focuses on the research and development of a standardized STEM (Science, Technology, Engineering, and Mathematics) lab operating procedure, integrating smart technologies in Vietnamese secondary schools to meet the requirements of the 2018 national curriculum. The aim of this study is to create an effective, diverse, and engaging STEM learning environment for students. The research aims to identify and design a standardized STEM lab operating procedure that aligns with the requirements of the 2018 curriculum. The study employs a theoretical research approach to understand international standards and principles of STEM lab design. During the research process, relevant literature, textbooks, and previous studies on STEM and the integration of smart technologies in education were explored and analyzed. The standards of the 2018 curriculum were also examined to gain a clear understanding of its requirements for implementing STEM in secondary schools. Based on the theoretical research and standards, the STEM lab operating procedure was designed and developed. The procedure includes steps such as defining STEM learning objectives, selecting and implementing appropriate smart technologies, designing STEM activities, and evaluating the effectiveness of the procedure.
A produção científica sobre capacitismo na educação básica: Uma revisão integrativa de literatura
Authors: De Mamann Ferreira Simone , Gesser Marivete , Letícia Kempfer Böck Geisa , Carvalho Leandro Gabriel
Published: June 2023

Esta pesquisa visa caracterizar o modo como o capacitismo é reproduzido na educação básica e identificar contribuições para a construção de práticas educativas anticapacitistas. Os dados foram obtidos por meio de um estudo de revisão integrativa que abrangeu artigos científicos e ensaios teóricos publicados em periódicos internacionais e nacionais entre 2009 e 2020. As bases de dados utilizadas para o levantamento das publicações foram: Social Sciences Citation Index (Web of Science), Elsevier (Scopus), Scientific Eletronic Library Online (SciELO) e Educational Resources Information Centre (ERIC). A análise foi realizada por meio de um protocolo estruturado pelo(s) autore(s), contendo características mais gerais dos artigos e da análise de conteúdo (Bardin, 2004). As categorias emergentes a partir da coleta de dados foram: 1) reprodução do capacitismo na educação básica; 2) capacitismo como uma experiência interseccional; e 3) contribuições para práticas educativas anticapacitistas na educação básica. Concluiu-se que o capacitismo está presente nos planejamentos das atividades e nos currículos escolares e produz como efeito a manutenção de diversas barreiras que obstaculizam o acesso ao conhecimento e a participação de estudantes com deficiência na educação básica. Assim, a proposição e implementação de práticas educativas anticapacitistas é necessária e urgente para a garantia do direito à educação dessa população. Torna-se imprescindível que o capacitismo seja inserido como uma temática a ser discutida nas formações docentes bem como na composição da produção do conhecimento para maior disseminação do conceito na sociedade.
Isolasi Dan Identifikasi Mikoriza Yang Berasosiasi Dengan Akar Acriopsis Javanica, Bulbophyllum Angustifolium, Dan Dendrobium Flafensen Di Kebun Raya Baturraden
Authors: Ria Dewi Dili Hastuti Ria Dewi Dili Hastuti , Lili Sugiyarto Lili Sugiyarto , Anna Rahmawati Anna Rakhmawati
Published: June 2023

Anggrek merupakan tanaman hias yang banyak digemari pecinta tanaman, karena bentuk bunga dan daunnya unik.Kebun Raya Baturraden merupakan sarana konservasi tumbuhan hutan, salah satunya adalah konservasi anggrek hutan.Biji-biji anggrek hanya terdiri dari embrio dibungkus oleh lapisan testa dan tidak mengandung endosperm.Sehingga biji anggrek sulit atau bahkan tidak mampu untuk berkecambah. Oleh sebab itu dalam proses perkecambahan, perkembangan dan pertumbuhan anggrek memerlukan infeksi hifa fungi yang dikenal dengan  istilah mikoriza anggrek (orchid mycorrhiza). Tujuan penelitian untuk mengetahui genus jamur mikoriza yang berasosiasi pada akar anggrek Acriopsis javanica, Bulbophyllum angustifolium, dan Dendrobium flafensen di Kebun Raya Baturraden, mengetahui persentase kepadatan infeksi mikoriza pada akar anggrek epifit, mengetahui bagian jaringan akar yang umum ditempati jamur mikoriza, dan mengetahui faktor lingkungan dan ketinggian tempat terhadap keberadaan genus mikoriza.Metode yang digunakan yaitu pengambilan sampel akar anggrek epifit dengan metode transek, pengamatan fungi mikoriza menggunakan metode pemanasan akar dengan KOH dan freehand sections, isolasi dan identifikasi jamur mikoriza berdasarkan buku Identifications of Mikoriza dan INVAM.Hasil penelitian menunjukkan spora FMA pada akar tanaman anggrek di Kebun Raya Baturraden didominasi oleh genus Glomus sp, diikuti Rhizoctonia sp, Sclerocytis sp, dan Gigaspora  sp. Persentase kepadatan infeksi mikoriza tidak merata pada setiap jaringan akar. Bagian akar yang paling umum ditempati mikoriza adalah jaringan korteks.Faktor lingkungan berpengaruh terhadap keberadaan genus mikoriza, tetapi ketinggian tempat tidak berpengaruh terhadap keberadaan genus mikoriza pada jaringan akar anggrek. Kata Kunci : Anggrek Epifit, Mikoriza Anggrek, Kebun Raya Baturraden
STRUKTUR KOMUNITAS ARTHROPODA DI TANAH PERMUKAAN GUA JLAMPRONG, GUNUNGKIDUL
Authors: Azizah Dila Novianti Azizah Dila Novianti , Tien Aminatun Tien Aminatun , Triatmanto Triatmanto
Published: June 2023

Penelitian ini bertujuan untuk mengetahui keanekaragaman dan struktur komunitas arthropoda di tanah permukaan Gua Jlamprong, Gunungkidul. Tiga sampel tanah diambil sebanyak 2,5 kg per sampel di tiap zona, kemudian diekstraksi dan arthropoda terekstraksi kemudian diidentifikasi. Faktor abiotik juga diukur di semua zona. Hasilnya adalah di tiga zona indeks diversitasnya rendah. Di zona terang teridentifikasi 11 ordo arthropoda dan 215 individu dengan ordo yang mendominasi Coleoptera dan Acari. Di zona remang, teridentifikasi 5 ordo dan 37 individu dengan ordo yang mendominasi adalah Polydesmidan dan Acari, dan di zona gelap teridentifikasi 6 ordo dn 121 individu dengan Acari yang mendominasi. Keberadaaan jumlah individu tiap ordo juga tidak merata di tiap zona sehingga indeks kemerataannya rendah.Kata kunci: Gua Jlamprong, arthropoda, tanah permukaan, struktur komunitas, keanekaragaman