bluuebunny/crossref_metadata_2025 huggingface dataset:
Suppl. Fig. 18 from Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Authors: Penter Livius , Cieri Nicoletta , Maurer Katie , Kwok Marwan , Lyu Haoxiang , Lu Wesley S. , Oliveira Giacomo , Gohil Satyen H. , Leshchiner Ignaty , Lareau Caleb A. , Ludwig Leif S. , Neuberg Donna S. , Kim Haesook T. , Li Shuqiang , Bullinger Lars , Ritz Jerome , Getz Gad , Garcia Jacqueline S. , Soiffer Robert J. , Livak Kenneth J. , Wu Catherine J.
Published: November 2024

Mutational signatures of mitochondrial DNA (mtDNA) identified using ASAP-seq.
Suppl. Fig. 12 from Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Authors: Penter Livius , Cieri Nicoletta , Maurer Katie , Kwok Marwan , Lyu Haoxiang , Lu Wesley S. , Oliveira Giacomo , Gohil Satyen H. , Leshchiner Ignaty , Lareau Caleb A. , Ludwig Leif S. , Neuberg Donna S. , Kim Haesook T. , Li Shuqiang , Bullinger Lars , Ritz Jerome , Getz Gad , Garcia Jacqueline S. , Soiffer Robert J. , Livak Kenneth J. , Wu Catherine J.
Published: November 2024

Deconvolution of chimeric populations using mitochondrial DNA mutations and germline single nucleotide polymorphisms.
Supplementary Table 2 from Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes
Authors: Thibaud Santiago , Subaran Ryan L. , Newman Scott , Lagana Alessandro , Melnekoff David T. , Bodnar Saoirse , Ram Meghana , Soens Zachry , Genthe William , Brander Tehilla , Mouhieddine Tarek H. , Van Oekelen Oliver , Houldsworth Jane , Cho Hearn Jay , Richard Shambavi , Richter Joshua , Rodriguez Cesar , Rossi Adriana , Sanchez Larysa , Chari Ajai , Moshier Erin , Jagannath Sundar , Parekh Samir , Onel Kenan
Published: November 2024

SUPPLEMENTARY TABLE 2: PGV Classification and Allele Count by Cohort
Supplementary Figure 2 from Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes
Authors: Thibaud Santiago , Subaran Ryan L. , Newman Scott , Lagana Alessandro , Melnekoff David T. , Bodnar Saoirse , Ram Meghana , Soens Zachry , Genthe William , Brander Tehilla , Mouhieddine Tarek H. , Van Oekelen Oliver , Houldsworth Jane , Cho Hearn Jay , Richard Shambavi , Richter Joshua , Rodriguez Cesar , Rossi Adriana , Sanchez Larysa , Chari Ajai , Moshier Erin , Jagannath Sundar , Parekh Samir , Onel Kenan
Published: November 2024

SUPPLEMENTARY FIGURE 2: Overall Survival (OS) in PGV-A carriers vs non-carriers
Data from Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Authors: Penter Livius , Cieri Nicoletta , Maurer Katie , Kwok Marwan , Lyu Haoxiang , Lu Wesley S. , Oliveira Giacomo , Gohil Satyen H. , Leshchiner Ignaty , Lareau Caleb A. , Ludwig Leif S. , Neuberg Donna S. , Kim Haesook T. , Li Shuqiang , Bullinger Lars , Ritz Jerome , Getz Gad , Garcia Jacqueline S. , Soiffer Robert J. , Livak Kenneth J. , Wu Catherine J.
Published: November 2024

Abstract
Combined tracking of clonal evolution and chimeric cell phenotypes could enable detection of the key cellular populations associated with response following therapy, including after allogeneic hematopoietic stem cell transplantation (HSCT). We demonstrate that mitochondrial DNA (mtDNA) mutations coevolve with somatic nuclear DNA mutations at relapse post-HSCT and provide a sensitive means to monitor these cellular populations. Furthermore, detection of mtDNA mutations via single-cell assay for transposase-accessible chromatin with select antigen profiling by sequencing (ASAP-seq) simultaneously determines not only donor and recipient cells but also their phenotype at frequencies of 0.1% to 1%. Finally, integration of mtDNA mutations, surface markers, and chromatin accessibility profiles enables the phenotypic resolution of leukemic populations from normal immune cells, thereby providing fresh insights into residual donor-derived engraftment and short-term clonal evolution following therapy for post-transplant leukemia relapse. As throughput evolves, we envision future development of single-cell sequencing–based post-transplant monitoring as a powerful approach for guiding clinical decision-making.

Significance: mtDNA mutations enable single-cell tracking of leukemic clonal evolution and donor–recipient origin following allogeneic HSCT. This provides unprecedented insight into chimeric cellular phenotypes of early immune reconstitution, incipient relapse, and quality of donor engraftment with immediate translational potential for future clinical post-transplant monitoring and decision-making.
Data from Repurposing NAMPT Inhibitors for Germinal Center B Cell–Like Diffuse Large B-Cell Lymphoma
Authors: Scuoppo Claudio , Cai Bowen , Ofori Kenneth , Scholze Hanna , Kumar Rahul , D’Alessandro Angelo , Basso Katia , Pasqualucci Laura , Dalla-Favera Riccardo
Published: November 2024

Abstract
Diffuse large B-cell lymphoma (DLBCL) includes the activated B cell–like (ABC) and germinal center B cell–like (GCB) subtypes, which differ in cell of origin, genetics, and clinical response. By screening the subtype-specific activity of 211 drugs approved or in active clinical development for other diseases, we identified inhibitors of nicotinamide phosphoribosyl transferase (NAMPTi) as active in a subset of GCB-DLBCL in vitro and in vivo. We validated three chemically distinct NAMPTis for their on-target activity based on biochemical and genetic rescue approaches and found the ratio between NAMPT and PARP1 RNA levels was predictive of NAMPTi sensitivity across DLBCL subtypes. Notably, the NAMPT:PARP1 transcript ratio predicts higher antitumor activity in BCL2-translocated GCB-DLBCL. Accordingly, pharmacologic and genetic inhibition of BCL2 was potently synergistic with NAMPT blockade. These data support the inhibition of NAMPT as a therapeutically relevant strategy for BCL2-translocated DLBCLs.

Significance: Targeted therapies have emerged for the ABC subtype of DLBCL, but not for the GCB subtype, despite the evidence of a significant subset of high-risk cases. We identify a drug that specifically targets a subset of GCB-DLBCL and provide preclinical evidence for BCL2 translocations as biomarkers for their identification.
Supplementary Table S5 from Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer
Authors: Hayashi Hidetoshi , Nishio Makoto , Akamatsu Hiroaki , Goto Yasushi , Miura Satoru , Gemma Akihiko , Yoshino Ichiro , Misumi Toshihiro , Kijima Takashi , Takase Naoto , Fujita Masaki , Tasaka Sadatomo , Mouri Atsuto , Kondo Tetsuro , Takamura Kei , Kawashima Yosuke , Imaizumi Kazuyoshi , Iwasawa Shunichiro , Nakagawa Shintaro , Mitsudomi Tetsuya
Published: November 2024

Supplementary Table S5. Association between grade ≥3 irAEs and predictors of ICI effect a Mann–Whitney U Test. b Patients who had progression within 4 or 6 weeks after the initiation of treatment were excluded. Abbreviations: CRP, C-reactive protein; ICI, immune checkpoint inhibitor; IHC, immunohistochemical; irAE, immune-related adverse event; NLR, neutrophil-to-lymphocyte ratio; PD-L1, programmed death ligand-1; Q, quartile; SD, standard deviation.
Responsiveness of the Dermatology Life Quality Index and the Colombian Validated Version of the Skindex-29 in Scarring and Non-Scarring Alopecia
Authors: Sanchez Jurany , Mora Cristian , Mancilla Gener Alejandro , Sanclemente Gloria
Published: November 2024

Introduction: Alopecia is a frequent reason for consultation and is often associated with psychological, self-esteem, and quality of life (QoL) impact, particularly in women. To date, QoL assessment studies including all alopecia types are lacking. This study evaluated QoL and sensitivity to change of the Skindex-29 and the Dermatology Life Quality Index (DLQI) in these. Methods: This was an observational study with a longitudinal design, including two measurements over time and prospective data. It was carried out in four outpatient centers in Medellín, between 2023 and 2024. We included sociodemographic and clinical data, as well as the DLQI and Skindex-29 QoL questionnaires before and after treatment. Results: Participation of women was 51%; the most frequent types of alopecia were androgenic alopecia (52%), alopecia areata (AA) (19%), and telogen effluvium (TE) (9%). The alopecia types with the greatest impact on QoL (pretreatment) measured through the DLQI and the Skindex-29, respectively, were TE (10.29 [±9.32] and 40.39 [±32.04]), AA (9.27 [±9.13], and 33.91 [±26.47]), dissecting cellulitis (8.67 [±8.33] and 29.6 [±15.33]), and lichen planus pilaris (6.75 [±6.55] and 6.75 [±6.55]). Conclusion: The version validated in Colombia of the Skindex-29 and the Colombian Spanish version of the DLQI showed a moderate responsiveness when evaluating the QoL of patients with scarring and non-scarring alopecia, before and after starting specific treatment.
Clinical and Genetic Mechanisms in Patients with MC2R Deficiency Presenting with Early Puberty
Authors: Karakilic Ozturan Esin , Yavas Abali Zehra , Karaman Volkan , Poyrazoglu Sukran , Uyguner Zehra Oya , Darendeliler Feyza , Bas Firdevs
Published: November 2024

Introduction: Melanocortin receptor 2 (MC2R) in the adrenal cortex controls the hypothalamic-pituitary-adrenal axis. The melanocortin system, influenced by leptin, regulates GnRH neurons, crucial for puberty onset and fertility. This study evaluates early puberty in primary adrenal insufficiency (PAI) patients due to MC2R gene alterations. Methods: Seven patients with PAI (P1-P7) from five unrelated families, all presenting with early or precocious puberty, were included. MC2R deficiency diagnosis ranged from 1 day to 11 months. MKRN3, DLK1, KISS1, and KISS1R genes were analyzed using Sanger sequencing in four cases (P2, P4, P6, and P7). All clinical data were obtained retrospectively. Results: Puberty onset mean age was 8.6 years (7.4–9.5) in boys (P1, P2, P3, P7) and 8.5 years (7.4–9.5) in girls (P4, P5, P6). Tumor markers were negative; no adrenal rest or tumors were found. GnRH analogs were used for rapid puberty in P2, P3, P6. Final height in P1 and P2 was below target (−2.6 SDS, −0.7 SDS). Menarche occurred at 11 and 11.3 years in P4 and P5. No pathogenic variants were found. Conclusion: Genetic causes of early puberty were not identified. Elevated ACTH may stimulate kisspeptin neurons, triggering puberty. Close monitoring of these patients for pubertal development is recommended.
Removal of Meropenem and Piperacillin during Experimental Hemoadsorption with the HA380 Cartridge
Authors: Furukawa Taku , Lankadeva Yugeesh , Baldwin Ian , Ow Pei Chen Connie , Hood Sally , Schneider Antoine , Decosterd Laurent A. , May Clive N. , Bellomo Rinaldo
Published: November 2024

Introduction: Hemoadsorption can be used as adjunctive therapy for sepsis. However, there is limited evidence regarding its antibiotic removal. In this in vivo preclinical study, we aimed to evaluate the removal of meropenem and piperacillin with the HA380 hemoadsorption cartridge. Methods: Healthy adult sheep (n = 6) received 2 g of meropenem and 4 g of piperacillin intravenously for 30 min followed by hemoadsorption with a HA380 cartridge at a blood flow rate of 120 mL/min for 4 h. The sorbent-based removal ratio, clearance, and mass removal were calculated at multiple time points. Results: The sorbent-based removal ratio of meropenem decreased from 95.4% (SD 1.8) at 10 min to less than 20% at 4 h of hemoadsorption. Its cumulative sorbent-based mass removal was 386.6 mg (SD 78.8) over 4 h with 65.6% (SD 7.1) occurring in the first 60 min. In contrast, the sorbent-based removal ratio of piperacillin decreased more gradually from 98.4% (SD 0.6) at 10 min to 37.4% (SD 7.2) at 4 h. Its cumulative sorbent-based mass removal was 647.4 mg (SD 191.3) over 4 h with 63.4% (SD 4.2) occurring in the first 60 min. The overall sorbent-based clearance of piperacillin was significantly greater than meropenem (pgroup < 0.0001). Conclusion: Hemoadsorption with the HA380 cartridge removed meropenem and piperacillin throughout a 4-h period, with high clearances at the start. Our findings can be used to inform dosing decisions during hemoadsorption in septic patients, there may be the need to consider increasing the doses of these antibiotics by 15–25% to prevent underdosing.
The battle of learning modes: hybrid vs online learning in higher education
Authors: Ma'arif Mahmuda , Santoso Ridwan , Arif Dikdik Baehaqi , Nuryana Zalik
Published: November 2024

This study aims to compare the impact of hybrid learning and online learning on students' understanding of concepts at the college level. The type of research used in this study was a quasi-experimental control group design. This research data collection technique was obtained from 100 students who attended civic education lectures. The number of research samples was 100 students consisting of various study programs from the results of random sampling. Data was analyzed using independent sample t-test and paired sample t-test analysis techniques. The results indicate that hybrid learning is more effective in increasing students' understanding of material concepts. However, both types of learning have a significant impact on improving students' understanding of concepts. The findings of this research can be utilized to optimize Pancasila learning in higher education and provide comprehensive insights into the benefits of hybrid and online learning. The study concludes that hybrid learning, which combines face-to-face and online learning, is a highly effective form of learning in educational institutions. This is particularly relevant in the current global context, where educational institutions worldwide are grappling with the challenges posed by the COVID-19 pandemic.
Turn taking patterns, repair and adjacency pairs in an online interaction: a conversation analysis
Authors: Fatimah Nur , Widodo Pratomo , Andriyanti Erna
Published: November 2024

The present study analyzed the use of conversation analysis (CA) in online interaction. The aim of the study is to describe the patterns of turn taking, repair, and the adjacency pairs in the online conversation. Employing a qualitative research methodology, data were taken from an online conversation about how to learn English, taking place in YouTube between a professor of English language teaching and the host who is a professor of education. The conversation was mainly in Bahasa Indonesia. The data were first transcribed in Bahasa Indonesia and translated into English. The study found some structures of exchange in the communication and the patterns of turn taking, repairs and adjacency pairs evident from the analysis of conversation. There are some patterns of turn-taking and adjacency pairs along the online conversation. The turn constructional units vary in syntactical forms. In addition, both self-initiated and other initiated-self repairs occurred. The study drew the implication of CA to language teaching. CA contributes to language teaching in terms of offering not only the authentic real-life communication, but also the authentic spoken interaction which will encourage learners to be able to produce authentic utterances.
Employability model for students in increasing career opportunities
Authors: Binasari Erni Suci , Tentama Fatwa
Published: November 2024

The objective of this study was to create and develop an employability model, and the factors that influence be investigated in a proper environment. These students are working at STIE SBI Yogyakarta to determine the adequacy of the model's shape in considering the field-occurring factors. The population of this study was all active students at STIE SBI in Yogyakarta who are currently working. The sample in this study was 101 working STIE SBI students. The technique of sampling in this research used accidental sampling. The data collection instrument used a scale of employability, scale resilience, and the peer social support scale. Data analysis techniques in this study were carried out quantitatively. The analytical method used equation modeling partial least squares path modeling (SEM-PLS) 4.0 through testing the outer and inner models. This study's results were the formation of resilience and peer support models on the employability of working students who appropriate with empirical data. There is a positive and very significant effect of resilience on the employability of working students. The theoretical model formed in this study was an appropriate model that can be used as a valid model reference in developing employability variables.
Managing students’ learning interest in civics learning through a genially-based interactive multimedia
Authors: Arum Wahyu Sri Ambar , Khalilah Hana Naurah , Marini Arita , Yarmi Gusti , Safitri Desy , Dewiyani Leola
Published: November 2024

This study aims to create a Genially based interactive multimedia product to increase interest in learning civics among fifth-grade students. This research and development type uses the analyze, design, develop, implement, and evaluate (ADDIE) model. This study used three samples in the one-to-one stage, six in the small group stage, and 26 in the field test stage. This media produces media quality with a total score percentage of 88%, categorized as very feasible through media expert validation. This product also makes material quality with a total score percentage of 94%, classified as very feasible through content expert validation. The product effectiveness test through the N-Gain test obtained a total score percentage of 1%, which was included in the high category. This study concludes that Genially-based interactive multimedia effectively increases students' interest in civics.
Muara Takus Temple in the digital dimension: increasing historical understanding through augmented reality
Authors: Bunari Bunari , Isjoni Isjoni , Fikri Asyrul , Yuliska Yuliska
Published: November 2024

This research aims to investigate the impact of using augmented reality (AR) at Muara Takus Temple as a source of history learning for students' historical understanding. Experimental research methods were involved in this research. 88 secondary school students were used as samples. They were split into two groups, the experimental group and the control group, each of which had 44 randomly chosen participants. A history test and a questionnaire used for collecting data. Historical understanding data was analyzed using statistical analysis such as the t-test to compare differences between the experimental group and the control group. Data from the questionnaire was analyzed descriptively to identify user experience and satisfaction with the AR application. The computed t score of 6.21 is significantly higher than the 2.00 t table value. These findings indicate that the use of AR in history learning can increase student understanding and engagement. Apart from that, the use of AR also increases students' interest, motivation and interaction abilities and provides immersive experiences in history learning. This research confirms that AR has great potential to improve students' historical understanding while stimulating their interest, motivation, and interaction abilities in history subjects.
The scale of sincerity based on Kyai Haji Ahmad Dahlan's version for Islamic students: the Rasch analysis
Authors: Saputra Wahyu Nanda Eka , Handayani Trikinasih , Rohmadheny Prima Suci , Naini Rohmatus , Hartanto Dody , Santosa Hardi , Khairunnisa Dewi Afra , Risansyah Risma , Riati Hanan , Faturrahman Faturrahman
Published: November 2024

The students are urged to do something without expecting anything in return and only in the name of God. Every islamic student becomes something ideal if they can internalize and implement sincerity. Many people are willing to do something because of an ulterior motive. The importance of sincerity in humans is the background for developing a sincerity scale that measures personal sincerity. One of the figures who gave an example of sincere behavior was Kyai Haji (KH) Ahmad Dahlan, so the sincerity scale was adjusted to the character's sincere behavior. This scale consists of four indicators: having transcendental motives, the ability to control emotions, the absence of a sense of superiority, and being a servant of God. Two experts in Islamic psychometry tested KH Ahmad Dahlan's version of the sincerity scale. Besides that, construct validity involved 252 students. We employed Cohen's Kappa inter-rater reliability (IRR) coefficient and Rasch analysis as data analysis methods. The findings from Cohen's Kappa indicate that both experts concurred on the accuracy of the instrument's statement items. Additionally, the Rasch analysis reveals that the sincerity scale, based on KH Ahmad Dahlan’s version, is reliable, accurate, and fits well with the model.
An exploration of students’ creativity through a mixed-methods study in the classroom
Authors: Aziz Rahmat , Maimun Agus , Hamid Abdul , Masturin Masturin , Efiyanti Alfiana Yuli
Published: November 2024

Students’ creativity is a fundamental goal in education. The school has a strategic role in developing students’ creativity. This study elaborates on classroom activities to develop students’ creativity. The study used a mixed-method sequential explanatory design. Quantitative data were obtained from six hundred and one students from junior and senior high schools in East Java, Indonesia. Qualitative data were obtained from nine teachers. Descriptive and regression analysis techniques are used to analyse quantitative data, while thematic analysis is used to analyse qualitative data. The results show that the hypothesis is accepted. It means that classroom climate affects students’ creativity. The findings also showed three classroom activities for developing students’ creativity: rule, positive teaching and teacher support. Teachers’ ability to manage learning in the classroom affects the high level of students’ creativity.
Formation of media competence based on organization of project activities of future teachers within blended learning
Authors: Galustyan Olga V. , Vlasyuk Irina V. , Zhirkova Galina P. , Gamisonija Saida S. , Zhang Jingwei , Liu Siqi
Published: November 2024

The article is devoted to the problem of formation of media competence which is based on organization of project activities of future teachers within blended learning. Rapid development of digital technologies, expansion of wide public access to the content of various types (professional, educational, and entertainment) leads to the attraction of young people to social networks and Internet media resources. Application of modern media in education makes it possible to prepare highly qualified teachers who can solve professional problems effectively. Thus, the role of developing media competence of future teachers in the information society is increasing. The presented paper reveals the process formation of media competence based on organization of project activities of future teachers within blended learning which include creating educational media products. The results of experimental work of formation of media competence based on organization of project activities of future teachers within blended learning in control and experimental groups reveal that in the experimental group the level of media competence of future teachers is higher than in the control group, that proves the effectiveness of experimental work.
НАУКОВИЙ АНАЛІТИЧНИЙ ПОШУК ДОСЛІДЖЕННЯ ПРОБЛЕМ ПОШИРЕННЯ ГОСТРИХ РЕСПІРАТОРНИХ ЗАХВОРЮВАНЬ, ГРИПУ Т COVID-19 А COVID-19
Authors: Паничев В. О. , Сверстюк А. С. , Кучвара О. М. , Багрій-Заяць О. А. , Майхрук З. В.
Published: November 2024

Мета: аналіз за допомогою аналітичного пошуку джерел у наукометричній базі даних Scopus актуальності проблеми епідеміології і профілактики гострих респіраторних захворювань, грипу та COVID-19 в умовах воєнного стану.
Матеріали і методи. Пошуковим запитом з указаної теми в наукометричній базі Scopus за період 1993–2024 рр. знайдено 355 наукових праць. Проведено їх аналітичний огляд із розподілом за роками, країнами, університетами та науковцями світового рівня.
Результати. Незважаючи на військовий стан у країні, гострі респіраторні захворювання, грип та COVID-19 і надалі залишаються однією з найактуальніших медичних та соціальних проблем у силу здатності до їх швидкого епідемічного поширення навіть у теплий період року, появи нових генетичних варіантів вірусу SARS-COV-2, високої захворюваності, часто тяжкого клінічного перебігу та ризику розвитку небезпечних для здоров’я людини ускладнень, особливо в осіб вікового та медичного ризику, загострення хронічних хвороб і, як наслідок, летальності. Вказане підтверджується, зокрема, підвищенням захворюваності на COVID-19 у серпні місяці поточного року. Тому актуальними є аналітичний аналіз та розробка адекватних моделей для моніторингу, оцінки, епідемічної ситуації та своєчасного реагування на загрози розвитку епідемій із методами своєчасного впливу та запобігання поширенню захворювання. Актуальною є проблематика продовження спеціальних протиепідемічних заходів в умовах воєнного стану, що супроводжується міграцією населення, формуванням організованих колективів, проблемами доступу до своєчасної медичної допомоги на окремих територіях.
Висновок. За результатами аналітичного огляду в наукометричній базі Scopus питання епідеміології гострих респіраторних захворювань, грипу та COVID-19 у світі залишаються актуальними, зокрема найбільше досліджень із даної тематики проведено у провідних країнах світу: США, Великобританії, Австралії, Німеччині, Індії, Китаї та ін.
ЗБЕРЕЖЕННЯ ЗДОРОВʼЯ ІНСТРУКТОРІВ: ЯК ОПТИМІЗАЦІЯ РОБОТИ ПІДВИЩУЄ ЕФЕКТИВНІСТЬ ВІЙСЬКОВОЇ ПІДГОТОВКИ
Authors: Шацький В. В. , Березна С. О.
Published: November 2024

Мета: дослідження заходів з оптимізації роботи інструкторів з тактико-спеціальної підготовки, таких як перерозподіл навантаження, оптимізація режиму роботи і відпочинку, психологічна підтримка та соціальна активність.
Матеріали і методи. Проведено аналіз вітчизняних і закордонних досліджень щодо фізичного та психоемоційного стану інструкторів в умовах постійних і зростаючих викликів. Використано бібліосемантичний метод та системного аналізу.
Результати. У статті здійснено всебічний аналіз сучасних проблем, пов’язаних із фізичним, моральним та психічним здоров’ям інструкторів, і запропоновано конкретні заходи для їх поліпшення.
У статті розглянуто кілька ключових аспектів, що впливають на здоров’я інструкторів. По-перше, проаналізовано проблему надмірного фізичного навантаження, яке може призвести до фізичних травм та втоми. Запропоновано ефективні стратегії для оптимізації фізичної підготовки та розробки спеціалізованих тренувальних планів, які дозволять зменшити ризик травм і поліпшити загальний фізичний стан інструкторів.
По-друге, акцентовано увагу на моральному та психічному вигоранні, яке є наслідком постійного стресу і високих вимог. Запропоновано методи для профілактики та подолання вигорання, включаючи зміни у методичних підходах до тренувань, запровадження елементів гнучкого планування і впровадження нових технологій та інновацій у підготовці особового складу.
Також акцентується на необхідності впровадження комплексної психологічної підтримки. Наявність психологів або консультантів для роботи з інструкторами, регулярні тренінги з управління стресом, а також програми для розвитку навичок емоційної стійкості можуть суттєво допомогти в підтримці психічного здоровʼя. Окремо розглянуто важливість соціальної активності та взаємодії з родинами.
Висновки. У сучасних умовах збройних конфліктів ефективність підготовки військових значною мірою залежить від якості роботи інструкторів, які стикаються з надмірним фізичним і психологічним навантаженням. Оптимізація їхньої діяльності є критично важливою для підтримки високого рівня підготовки й забезпечення загальної ефективності навчального процесу.
From the Jordan to Mt. Ebal and Back
Authors: Segal Michael
Published: November 2024

This study explores the textual dynamics both within and between the law in Deut 27 and the narratives in Josh 3–4 and 8. It includes original analyses of: (a) the narrative of the Jordan crossing and its internal contradictions and ambiguities; (b) the internal rewriting and textual developments of the law in Deut 27:1–8; (c) the establishment of the altar in Josh 8:30–35 (MT), and its transfer to the Jordan crossing scene in 4QJosha; (d) the textual development of Deut 11:29–30; (e) the contribution of rabbinic literature towards elucidating the processes analyzed above; (f) the exegetical background of the so-called “Gerizim Composition” in SP, unrelated to sectarian concerns. These developments illustrate the dynamic interplay between literary history, transmission, and interpretation, and they underscore the fundamental importance of exegesis as a catalyst in these processes.
Conflicting Islamic Governmentality
Authors: Bekkaoui Hamza
Published: November 2024

In October 2021, Imam Mohamed Toujgani, a Moroccan who had resided in Belgium for nearly 40 years, was banned from the Schengen area for a decade. He was accused of espousing anti-Semitic views and having ties to Moroccan intelligence, posing a threat to societal harmony. This article critically examines the ban by putting it within the context of Europe’s securitisation of Islam. It explores Toujgani’s theological and social views, highlighting his promotion of dual belonging – a notion supported by the works of scholars such as Thijl Sunier on Islam in Europe. Employing Michel Pêcheux’s relational discursive approach, this study argues that Toujgani’s deportation risks deepening social divisions, potentially escalating conflicts rather than mitigating them.
Unique Structure of Co3O4 Nanomaterials for Superior Electrochemical Energy Storage Applications
Authors: Zhang Nailong , Gao Chao , Qiu Gang , Li Hongze
Published: November 2024

High specific capacitance, rapid charge–discharge kinetics, good cycle stability, scalability, and synthetic control are just a few of the many advantages that Co3O4 nanoflowers provide as electrode materials for supercapacitors. Based on the aforementioned
outstanding capabilities, Co3O4 nanoflowers are attractive options for a range of energy storage uses, such as grid-level energy storage, electric cars, portable devices, and renewable energy systems. Herein, Co3O4 nanoflowers as an electrode materials
exhibit outstanding electrochemical supercapacitance of 700 F/g at 15 A/g, with an exceptional 5000 cyclic stability and retention of 97.8%, rapid charge–discharge kinetics, excellent cycling stability and scalability. In order to facilitate the practical deployment of Co3O4
nanoflowers-based supercapacitors in real-world applications, ongoing research and development activities are concentrated on improving the performance and durability of these devices.
Artificial Hole Effect of YBa2Cu3O7–y Superconducting Bulk
Authors: Lee Sang-Heon
Published: November 2024

Previous studies showed that the superconducting properties of YBCO bulk could be improved by providing a path for oxygen diffusion into the crystal, made by drilling artificial holes in the bulk. Proposed in this paper is a process to provide artificial holes by forming holes by molding.
The gas formed from chemical reactions inside the superconducting bulk cannot escape because of highly viscose surrounding materials with high melting points. When holes are provided in the YBCO superconductor bulk, the holes can act as paths for the gas to escape, which would result in the
reduction of porosity. The levitation force of the superconductor due to the Meisner Effect was measured in the cooled condition without magnetism. The number and size of pores in the superconductor decreased as the surface area provided by the artificial holes in the superconducting bulk
increased. Both the magnetic levitation force and the trapped magnetic force measured at 77 K of the specimen with a 2.5 mm diameter hole were 135 N and 344 mT respectively, which were 16.8% higher than those of the specimen without a hole. The reasons for the higher magnetic levitation force
of the specimen with a hole seem that the single crystalline grain does not get disconnected because the density of porosity decreased due to the larger surface area, and that the efficiency of annealing improved because the area for oxygen to diffuse increased during annealing.
Characterization of Oxide Growth on Al–7mass%Mg Alloy Melts with Different Heating Rates
Authors: Ha Seong-Ho , Kim Bong-Hwan , Yoon Young-Ok , Lim Hyun-Kyu , Kim Shae K.
Published: November 2024

In this study, changes in the oxide growth behavior of Al–7mass%Mg alloy melts at different heating rates were investigated. The melted surfaces immediately after full melting showed no significant change, depending on the heating rate. After melt holding for 24 h, the surface
layers are thickly grown, and they become bumpy at the slowest heating rate. Cross-sections of the melts air-cooled after melt holding for 24 h showed coarse oxide clusters and significantly formed pores near the surfaces. Based on compositional analysis of the oxide clusters using a microscope,
oxygen contents in the oxide areas were higher than other constituent elements, indicating that the oxide clusters might contain a significant amount of gas. The compositions measured for the oxide clusters were located in the MgO–spinel–O2 region of the isothermal Al–Mg–O
ternary phase diagram at 700 ºC.
Structural, Morphological, and Photoluminescence Studies of Eco-Friendly Synthesized Allium sativum Extract Based Zinc Oxide Nanorods Inhibit HSA Glycation
Authors: Alsukaibi Abdulmohsen K. D. , Khan Mohd Wajid Ali , Al-Otaibi Ahmed , Mechi Lassaad , Alimi Fathi Rabeh , Alshammari Eida M. , Alshamari Asma K. , Sherwani Subuhi , Ahmed Faheem , Umar Ahmad
Published: November 2024

Glycation of blood proteins causing several physiological and immunological health complications, particularly in diabetes, cancer, and Alzheimer. Extensive research is underway for the potential inhibitory molecules that can successfully inhibit the glycation reactions. Research in
nanotechnology has diverse areas of research dealing with different branches of applied sciences. An enormous innovations and novel research applications are arising from nanoparticle (NP) based research. Zinc oxide nanorods (ZnO-NRs) has unique physicochemical properties exhibiting compatibility
with biomolecules. In this work, eco-friendly synthesis of garlic (Allium sativum) extract coated ZnO-NRs (G-ZnO-NRs) was reported. Various techniques were employed such as X-ray diffraction, Raman spectroscopy, and transmission electron microscopy to confirm stability, size, and shape
of the synthesized ZnO-NRs. Photoluminescence (PL) studies showed the presence of near band edge peak and defect related peaks. G-ZnO-NRs were used in several HSA structural and glycation experiments to understand their protein structure protection and antiglycation functions. Significant
antioxidant, free radical activities, and HSA structure protection were observed by G-ZnO-NRs as compared to the garlic extract alone. Similarly, G-ZnO-NRs showed significantly better results for inhibition in HSA browning, decrease in amyloid structure, and AGE pentosidine inhibition were
evident, as compared to the extract alone. Thus, a unique G-ZnO-NRs have potential to be used as an effective antiglycation therapeutic agents which may protect against diabetes and other glycation-related disorders. Further research in this direction might solve the puzzles for a growing
disease in Alzheimer. Additionally, the prepared ZnO nanorods in this work could be potentially used for future optoelectronics applications including LEDs.
Constructing Hybrid Structured NiCoP Nanowires for High Performance Electrocatalysts
Authors: Wang Hao , Zhang Qifan , Cheng Yijia , Miao Lihua
Published: November 2024

The advancement of energy conversion technologies relies heavily on the development of advanced electrode materials with high specific capacitance and superior electrocatalytic properties. Hybrid structured samples was prepared through a hydrothermal method. The as-obtained products
possess excellent catalytic performance. The NiCoP exhibit excellent OER activity with a low overpotential. The findings suggest that the NiCoP material shows significant potential for high-performance electrocatalytic water splitting applications. This not only establishes a basis for further
research and advancement of phosphide-based nanoelectrode materials but also opens up new avenues for advancing energy storage and conversion technologies.
High-Performance Supercapacitor Electrodes for Enhanced Energy Storage in Microelectronic Devices Using Facile Green Synthesis of CdO Nanoparticles
Authors: Vennila S. , Leelavathi C. , Balaprakash V. , Thangavel K. , Arun Kumar S. , Kalyana Sundar J. , Ramesh R. , Altameem Torki
Published: November 2024

Transition metal oxides are gaining popularity as an impressive material for energy storage applications due to their easy synthesis and environmental safety. In this work, we successfully synthesised cadmium oxide (CdO-CT) nanoparticles with Citron (CT) fruit peel extracted solution
and pure cadmium oxide CdO, and utilized as a high-capacity positive electrode for supercapacitor applications. The co-precipitation methodology was carried to synthesised CdO-CT nanoparticles were confirmed through the various physico-chemical techniques. Moreover, the charge storage activities
of the CdO-CT/NF electrode were analysed through various electrochemical techniques. The produced CdO-CT electrode exhibits increased capacitance and electrochemical stability, which might be impacted by green technology for providing electroactive surfaces during charge storage.
High throughput sequencing reveals alterations in B cell receptor repertoires associated with the progression of hepatic cirrhosis to hepatocellular carcinoma
Authors: Zhao Yingying , Wang Fengyan , Lei Xiaofei , Li Ziqiang , Cao Qiwei , Jiang Runze , Xu Changqing , Li Kun
Published: November 2024

Background:

Hepatocellular carcinoma (HCC) is developed as a consequence of chronic liver cirrhosis, and both diseases are difficult to diagnose and differentiate. Accurate noninvasive biomarkers for HCC and liver cirrhosis are urgently needed.

Methods:

Here we used high-throughput sequencing to characterize the B cell receptor (BCR) repertoires from 36 HCC tumor samples and 10 liver cirrhosis (LC) tissue biopsies to understand the immune alterations during hepatic carcinogenesis.

Results:

The principal components analysis (PCA) showed that the pattern of BCR in HCC was distinct from that in LC. As measured by Clonality and Shannon indexes, the diversity of BCR repertoire was significantly lower in HCC than in LC (P < 0.01).

Conclusion:

Our results corroborated that the BCR diversity and composition could be closely correlated with hepatic carcinogenesis. And BCR repertoire may be used to predict the progression of HCC and design targeting immunotherapy in the near future.
Homo sovieticus and the Neoliberal Legacy of Polish Dissent
Authors: Wciślik Piotr
Published: November 2024

Democratic backsliding in eastern Europe has been often cast in terms of the uncivility of local political culture inherited from the past. For the postwar period, the figure of homo sovieticus has embodied that inheritance, and its continued allure owes a lot to its dissident pedigree. This essay presents an intellectual history of the uses of that theme across the 1989 divide and questions its relevance today. The preoccupation with homo sovieticus signaled a neoliberal turn in addressing the dilemmas of democratic transition from Communism, which I analyze in reference to A. O. Hirschman’s typology of reactionary rhetoric. While Solidarity in 1980–1981 championed a vision of democratic citizenship in which social, political, and civil rights were mutually supportive and indivisible, after martial law these different rights came to be seen as conflicting and incompatible, and the theme of homo sovieticus proliferated as the indexical figure of that conflict. This new standpoint, which supported the neoliberal transition from Communism, brought about a critical reassessment of Solidarity’s legacy and a new understanding of the role of the dissident vanguard in the transition process, which I call pre-emptive Thermidorianism. It provided the glue that held together the liberal center, made up of self-professed neoliberals as well as the ex-revisionist Left, whose acquiescence to the neoliberal turn was instrumental. Pre-emptive Thermidorianism was disastrous both for the liberal center and for post-1989 political culture more broadly, and that is why homo sovieticus stands today as the self-defeating intellectual legacy of Polish dissent.
“Me? I’m No Revolution. I’m No Heroine.” Reconfiguring the Dissident in Contemporary Polish Theater
Authors: Nguyen Vu Thuc Linh
Published: November 2024

The figure of the dissident has become one of the key symbols of political opposition to Communism in Poland, with former dissidents playing a significant role in shaping the post-socialist and liberal order. While highly visible political struggles in polarized Poland have been foregrounded in confronting the Communist and dissident past, the seemingly less spectacular and more modest attempts at rethinking and reinterpreting the figure of the dissident that has emerged in contemporary Polish theater have gone almost unnoticed. This article examines how two contemporary theatrical plays engage with the polarized political discourse in Poland by problematizing the complex and gendered experience of dissidence. The artistic and political significance of the plays is elucidated against the backdrop of conservative and right-wing tendencies in the contemporary public sphere and artistic world that redefine the broader context within which Polish cultural producers operate. Zooming in on how these performances generate new representations and meanings of the anti-Communist political opposition, the article shows how the plays offer an occasion for rethinking and reinterpreting the figure of the dissident and its troubled legacy. As they explore the fields of tension that open up between individual political commitment and the relational and collective experience of dissidence, the plays make visible how the figure of the dissident has become a tool in remaking a Communist and post-socialist past and shaping a polarized present.
The value of cross-cutting skills - hiring managers’ views
Authors: Andrade Maureen Snow , Seeley Eugene , Miller Ronald Mellado
Published: November 2024

Employer-valued skills, which are not specific to a discipline but apply to all majors in higher education institutions, are often referred to as cross-cutting skills, soft skills, 21st century skills, or essential learning outcomes. Although research has ranked these skills in order of importance based on employer surveys, it has not examined statistical differences between individual skills or groupings of skills. The current study took a nuanced approach to understanding the value of cross-cutting skills based on hiring managers’ responses to a survey about hiring practices for entry-level positions. Findings ascertained the primary importance of a degree, and that conceptual, human, and technical skills are equal in importance, contrary to established theory. The study also found no statistical differences among top-rated skills identified in previous research but established differences in groupings of core and specialized skills. Sector differences were identified as well as changes in valued skills post-COVID.
Pelvic osteotomy for pelvic canal stenosis after malunion pelvic fractures in cats
Authors: Suzuki Ryoichi , Shimada Masakazu , Fukuda Hideyuki , Munakata Shuntaro , Kamijo Keiji , Yamaguchi Shinya , Hara Yasushi
Published: November 2024

Objectives

The aim of this study was to assess the efficacy of pelvic osteotomy and ventral fixation of the ischium using cortical screws and polymethylmethacrylate (PMMA) for feline pelvic canal stenosis (PCS) associated with malunion after conservative management of pelvic fractures.

Methods

Surgical pelvic enlargement was performed for PCS in six cats. The medical records, including information on the patients, surgical procedures, defecation and complications, were reviewed. The sacral index (SI) and colonic:lumbar:vertebral ratio (CLVR) were evaluated based on pre- and postoperative radiographs.

Results

This study included five castrated male cats and one spayed female cat. Postoperative improvements in constipation and defecatory difficulty were noted in all cases. The postoperative SI was significantly higher (mean 0.93, range 0.72–1.13) than the preoperative SI (mean 0.59, range 0.45–0.74) ( P <0.001). However, no statistically significant change was found in the CLVR preoperatively and up to 3 months postoperatively. A successful union of the ilium was observed, without implant failures. One case developed necrosis of the pubic surgical wound.

Conclusions and relevance

This study indicated the potential benefits of pelvic osteotomy and ventral fixation of the pelvic floor using screws and PMMA for achieving pelvic cavity enlargement in treating feline PCS associated with defecatory problems.
Hemorrhagic stroke in children
Authors: Askarova Azhar E. , Zhurkabayeva Bayan D.
Published: November 2024

Hemorrhagic stroke (HS) in childhood accounts for almost 50% of childhood strokes, is among the top ten causes of deaths, or determines lifelong disability. These facts form significant socio-economic and demographic problems. The purpose of this review is to analyze current knowledge about HS in children. The data on HS terminology are presented, taking into account the International Classification of Diseases 11 edition. Attention is paid to the epidemiology of HS in children, including the results of individual local studies. The risk factors of HS in children were studied with an analysis of the causal, pathophysiological mechanisms of HS of various etiologies. The ideas about the clinical manifestations of HS in children are described. The analysis of HS treatment in children was carried out with an emphasis on achievements in neurointensive therapy of the acute period of HS. This review also includes information on the outcomes of HS in children.
Nature nourishes the feeling of being - A walking interview study exploring the meaning of participation in nature-based activities for people living with dementia
Authors: Toubøl Annemarie G. , Clemmensen Trine Holt , Busted Laila M.
Published: November 2024

This study aims to explore the meaning of participating in nature-based activities as seen from the perspective of people living with dementia. Being in a natural environment in contrast to a constructed environment has not previously been investigated, even though several studies have shown that nature-based activities may impact people’s well-being, feelings of happiness, and a feeling of maintaining selfhood. A qualitative design was applied in this study, using walking-interviews to explore the meaning of participating in nature-based activities. Interviews have been conducted with 15 people with mild to moderate dementia in three municipalities. The analytical process using reflexive thematic analysis resulted in an overall theme that participation in nature-based activity nourishes the person by creating a feeling of having value as a person. Further, three subthemes were identified: Oasis for being, linking to the past, present, and future, and feeling capable. The findings of this study indicate that sensory stimulation when being in nature promotes embodied narratives and experiences, which contributes to the feeling of connecting to oneself, and to feeling valuable as a capable human being. This provides an important implication for practice that accessible nature-based activities may provide an overlooked opportunity to support self-identity for people living with dementia. However, it is time for a cultural and discursive shift in nature-based activities, where a delicate balance ensures that people living with dementia can derive inherent value from simply being in nature.