bluuebunny/crossref_metadata_2025 huggingface dataset:
Possibilidades de percepção: arte brasileira e multisensorialidade
Authors:   Universidade Federal do Rio de Janeiro, Fonseca Ludimilla Alvarenga
Published: June 2023

O presente artigo configura o projeto de pesquisa que virá a ser desenvolvido durante o Mestrado em História e Crítica da Arte da Escola de Belas Artes da Universidade Federal do Rio de Janeiro. O projeto tem como objeto de estudo as produções artísticas baseadas em diferentes possibilidades perceptivas, que não necessariamente a visão. Ou seja, obras que apelam para diferentes órgãos do sentido, sobretudo aquelas que apelam especificamente para o olfato e o paladar (e as relações espontâneas entre sensações de caráter diverso, como, por exemplo, ocorre na sinestesia). Ao explorar a multisensorialidade, estas produções trazem à tona novos sentidos interpretativos para as realidades e contextos nos quais as exposições e o público estão inseridos.
SCIENTIST VISION TO FACE THE DYNAMIC OF GLOBAL CHANGE IN THE MISSION TO BUILD A CIVILIZATION OF KNOWLEDGE
Authors: Suwardana Hendra
Published: June 2023

Ilmu pengetahuan menempati posisi sentral sekaligus krusial di alam semesta ini. Tidak hanya dalam konteks tataran epistemologis, tapi juga dituangkan dalam teks kitab suci agama manapun tentang urgensinya manusia berilmu menggunakan akal fikirannya. Hal ini bisa disebut merupakan suatu suatu pengejah-wantaan dari konsepsi ontologis yang dimanifestasikan dalam bentuk praksis berfikir. Oleh karena itu, ilmu tidak bisa dari suatu institusi milik golongan tertentu, khususnya kaum aristokrasi (ilmuwan), tapi para aktivitas manusia dimuka bumi mempunyai tanggungjawab yang sama terutama untuk mengetahui diri dan alam sekitarnya. Atas kesadaran ini bahwa hakikat ilmu pengetahuan itu inovasi berupa pengetahuan akan teknologi dan informasi, maka sepantasnya piranti ini mampu menyelamatkan bumi dalam keberlanjutannya bukan justru malah mebahayakan masa depan penghuninya. Kesemuanya stack holder penghuni planet bumi merupakan satu rangkaian yang tidak terpisahkan dalam peranannya memenuhi kebutuhan kehidupannya. Sedangkan teknologi hanyalah alat piranti untuk memudahkan memenuhi kebutuhan bahkan keinginannya. Pada titik ini, khususnya ilmuwan mempunyai tanggungjawab peran yang lebih vital dalam berkonstribusi terhadap sesuatu yang bernilai dan pada ranah ini masuk wilayah aksiologis yang didalamnya terdapat masyarakat global yang saling terikat dan tidak bersekat sebagai subyek maupun objek yang riil baik secara nyata materi maupun immateri. Pola relasi tersebut dapat dilakukan dengan cara mengkonstruksi mind set absolute relation yang kongkrit baik secara implicit maupun eksplisit bagi manusia dalam membangun perdabannya dengan peradaban ilmu pengetahuan.

Kata kunci: Ilmu Pengetahuan, Ilmuwan, Filsafat Ilmu dan Peradaban.
ADOLESCENT’S KNOWLEDGE ABOUT THE RISK OF EARLY MARRIAGE RELATED TO ATTITUDE OF PREVENTING EARLY MARRIAGE IN KECAMATAN PARE KABUPATEN KEDIRI
Authors: RATNA FETI WULANDARI  , NURIN FAUZIYAH  , RATIH KUSUMA WARDHANI
Published: June 2023

Early marriage is a marriage that occur at the age of 18 years old. In 2020, early marriage was 19.26%. The population of women aged 10 years old and over who have ever been married carried out their first marriage at the age of less than 17 years old. The purpose of this study is how the relationship between adolescent’s knowledge about the risk of early marriage and the attitude of efforts to prevent early marriage. The research design method used cross sectional and the measuring instrument was a questionnaire. The independent variable is the knowledge of adolescents about the risk of early marriage while the dependent variable in this study is the attitude of efforts to prevent early marriage. The subjects were teenagers in Kecamatan Pare who had a girlfriend or had been in a relationship. The research sample was 300 respondents and the sampling technique is snowball. Data analysis using Spearman correlation test. The results showed that r = 0.237, sig (p) = 0.000, which means that there is a relationship between adolescent knowledge about the risk of early marriage and the attitude of efforts to prevent early marriage.
Keywords:         Knowledge, Early Marriage, Attitude, Adolescent
HIGH RISK PREGNANCY IN WOMEN WITH PREVIOUS C-SECTION AND SHORT INTERVAL PREGNANCY: CASE REPORT
Authors: Koerniawan Sekar Putri Kirana , Jayanti Ratna Dwi , Fitriana Farida
Published: June 2023

The main risk in pregnancies occur at 4T (too many, too young, too old, and too close birth spacing). The distance between the previous delivery and the next pregnancy and the previous method of delivery are two of the many other factors that affect the condition of the mother and the fetus that will be born later. This case report aims to analyze the effect of spacing between the last child and history of previous births on the outcome of the mother and her baby. This report describes data on pregnant women participating in the Continuity of Care (CoC) program. The results show that the outcomes obtained by the mother in this second delivery are within normal limits. However, this does not mean the possibility for pregnancies that are not planned properly to cause events that are detrimental to the mother and fetus are none.
A Puzzling Religious Inscription from Medieval Tuscany: Simbology and Interpretation
Authors: Vicari Stefano , Perono Cacciafoco Francesco
Published: June 2023

At the entrance of some churches in Tuscany (Italy), the reproduction of an apparently undecipherable inscription can be found. At least from the 18th century, this epigraphic puzzle has originated a debate on its interpretation. This study proposes a hypothesis based on the Latin alphabet used in texts contemporary to the churches where the inscription is reproduced and a possible interpretation of the message consistent with the official religious doctrine. The proposed deciphering is extended to the full text, including some signs that were previously considered as geometric forms or a specific elaboration of letters not attested in other contemporary documents.
Non-Destructive Analysis for Phosphorus Content in the Fruit of‘Huangguan’ Pear Based on Near-Infrared Spectroscopy
Authors: Li Liangjun , Fang Jing , Zhang Hanhan , Li Chen , Xu Jing , Jia Bing , Heng Wei , Ye Zhenfeng , Jin Xiu , Liu Li
Published: June 2023

'Huangguan' pear has significant social and economic value, and phosphorus, as one of the three main mineral elements of plants, has an irreplaceable effect on the normal growth of 'Huangguan' pear trees. The objective of this study was to predict the content of phosphorus in the pulp and peel of ‘Huangguan’ pears nondestructively and conveniently by using near-infrared spectroscopy (900–1700 nm) technology. First, twelve algorithms are used to preprocess the original spectral data, and the partial least squares regression algorithm and the gradient boosting regression tree algorithm are used to build a full-band prediction model based on the original spectral data and the processed spectral data. The characteristic wavelengths were extracted using genetic algorithms, followed by establishing a characteristic wavelength prediction model. The prediction accuracy of the models was evaluated according to the coefficient of determination R² and the relative analysis error RPD. The study found that the best prediction model for predicting phosphorus content in the pulp of 'Huangguan' pear was MSC-GA-PLSR, which had R²=0.843 and RPD=1.857 in the modelling set and R²=0.989 and RPD=7.041 in the prediction set. The best prediction model for predicting phosphorus content in the peel of ‘Huangguan’ pear was SG+SNV+FD-GA-PLSR, which had R²=0.991 and RPD=7.470 in the modelling set and R²=0.974 and RPD=4.414 in the prediction set, and the effect was good and met expectations. The results demonstrated that near-infrared spectroscopy could successfully achieve nondestructive detection of phosphorus content in the pulp and peel of 'Huangguan' pears.
Vibration and Aerodynamic Analysis and Optimization Design of a Test Centrifuge
Authors: Deng Chun-yan , He Li-dong , Tan Zhi-fu , Jia Xing-yun
Published: June 2023

Taking a certain type of test centrifuge as the research object, the finite element model of the test centrifuge is established, the vibration characteristics and aerodynamic performance of the test centrifuge are analyzed, and the structural optimization design of the test centrifuge is carried out. In this paper, the load is applied according to the actual working condition of a certain type of test centrifuge. The vibration of the mounting seat of the test centrifuge is analyzed and the structure of the mounting seat is optimized. After optimization, the vibration of the mounting seat is 77.38 % lower than that of the original mounting seat. Then, the aerodynamic analysis of the test centrifuge is carried out. The analysis results show that the test centrifuge moves more smoothly under the whole package shell and the steady flow shell, and the resistance decreases and the shaft load decreases. Finally, the steady flow shell of the test centrifuge is optimized. The analysis shows that the increase of the width of the steady flow shell can reduce the resistance coefficient, which is helpful to the stability of the test centrifuge during operation and reduces the unbalanced response of the system caused by air resistance.
Real-Time Exploration on Buildup Dynamics of Diode-Pumped Passively Mode-Locked Nd:YVO4 Laser with SESAM
Authors: Cheng Pi-Wen , Hsu Yu-Hsin , Wei-Chang Xiu , Liang Hsing-Chih , Chen Yung-Fu
Published: June 2023

The buildup dynamics of diode-pumped passively mode-locked solid-state laser is thoroughly explored by the real-time measurement with temporal sampling rate up to 40 GHz. A concise cavity is developed to ensure the transient dynamics purely arising from the gain medium and saturable absorber. Experimental results reveal that the laser output in the buildup process exhibits numerous passively Q-switched pulses followed with a damped relaxation oscillation prior to the stable mode locking. Furthermore, it is confirmed that the laser output has already displayed single clean mode-locked pulses inside the first several Q-switched envelopes before stepping into the stage of relaxation oscillation. The present real-time exploration is expected to provide important information for practical applications with temporal modulation of the pump intensity.
A Greener Approach to Spinach Farming: Drip Nutrigation with Biogas Slurry Digestate
Authors: Yadav Rashmi , Sudhishri Susama , Khanna Manoj , Lal Khajanchi , Dass Anchal , Kushwaha Hari Lal , Bandyopadhyay Kalikinkar , Suman Archna , Singh Anupama , Singh Rajiv Kumar , Singh Raj
Published: June 2023

To achieve higher crop yields and maintain environmental conservation, it becomes imperative to adopt novel agricultural methods that improve both the quantity and quality of produce. The above study focused on investigating the effectiveness of integrated use of biogas slurry (BS) and inorganic nutrigation on spinach growth and nutrient uptake through drip irrigation. Under field conditions and using a split plot design, spinach was cultivated with seven different treatments: biogas slurry nutrigation (BSN) (T1), integrated inorganic + organic nutrigation: 40% Recommended dose of fertilizer (RDF) +BSN (T2), 60% RDF +BSN (T3), 80% RDF +BSN(T4), 100% RDF(T5), slurry broadcasting (SB) (T6), and control(T7). The results showed that spinach grown with T4 80% RDF +BSN exhibited optimum plant height and leaf count compared to spinach under other treatments and was at par with T5 100% RDF for crop parameters. T5 treated plants demonstrated the longest roots, followed by T4 treated plants. The biomass produced by T4 was at par with T5 in the first (T4= 4.60 tonha-1, T5 =4.67 tonha-1) and second harvesting(T4= 6.69 tonha-1, T5 =6.89 tonha-1).In terms of macronutrient content in spinach leaves, significant differences were found only for nitrogen (N),potassium (K), while the phosphorus contents were not significantly influenced. Incorporating biogas slurry into the soil modifies microbial enzyme activities, specifically dehydrogenase and phosphatase. Normally, alkaline phosphatase shows greater activity than acidic phosphatase, but the addition of biogas slurry equalized the enzymatic activity of both, establishing a harmonized enzymatic profile. Fertilizing spinach with integrated Biogas slurry nutrigation + inorganic nutrigation not only improves growth and development to a similar extent as inorganic fertilizer but also enhances the nutrient content of the spinach, contributes to environmental preservation, and reduces production costs.
Genetic Diversity of Weedy Rice and Its Potential Application as a Novel Source of Disease Resistance
Authors: Osakina Aron , Jia Yulin
Published: June 2023

Weeds that infest crops are a primary factor limiting agricultural productivity world-wide. Weedy rice, also called red rice, has experienced independent evolutionary events through gene flow from wild rice relatives and de-domestication from cultivated rice. Each evolutionary event supplied/equipped weedy rice with competitive abilities that allowed it to thrive with cultivated rice and severely reduce yields in rice fields. Under-standing how competitiveness evolves is important not only for noxious agricultural weed management but also for the transfer of weedy rice traits to cultivated rice. Molec-ular studies of weedy rice using simple sequence repeat (SSR), restriction fragment length polymorphism (RFLP) and whole genome sequence have shown great genetic variations in weedy rice population globally. These variations are evident both at whole genome and at single allele level, including Sh4 (shattering), Hd1 (heading and flower-ing), and Rc (pericarp pigmentation). The goal of this review is to describe the genetic diversity of current weedy rice germplasm and the significance of weedy rice germplasm as a novel source of disease resistance. Understanding these variations, es-pecially at an allelic level, is also crucial as individual locus that control important traits can be of great target to rice breeders.
Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study
Authors: Tanaka Kazunari , Tsuji Kunihiko , Hiraoka Atsushi , Tada Toshifumi , Hirooka Masashi , Kariyama Kazuya , Tani Joji , Atsukawa Masanori , Takaguchi Koichi , Itobayashi Ei , Fukunishi Shinya , Ishikawa Toru , Tajiri Kazuto , Ochi Hironori , Toyoda Hidenori , Ogawa Chikara , Nishimura Takashi , Hatanaka Takeshi , Kakizaki Satoru , Shimada Noritomo , Kawata Kazuhito , Naganuma Atsushi , Kosaka Hisashi , Matono Tomomitsu , Kuroda Hidekatsu , Yata Yutaka , Ohama Hideko , Tada Fujimasa , Nouso Kazuhiro , Morishita Asahiro , Tsutsui Akemi , Nagano Takuya , Itokawa Norio , Okubo Tomomi , Arai Taeang , Yokohama Keisuke , Nishikawa Hiroki , Imai Michitaka , Koizumi Yohei , Nakamura Shinichiro , Iijima Hiroko , Kaibori Masaki , Hiasa Yoichi , Kumada Takashi
Published: June 2023

Aim: This study was to evaluate the predictive value of tumor marker (TM) score in patients with hepatocellular carcinoma (HCC) treated with Atezolizumab plus Bevacizumab (Atez/Bev) as a first-line chemotherapy.
Materials/Methods: From September 2020 to December 2022, 371 HCC patients treated with Atez/Bev, in whom alpha-fetoprotein (AFP), fucosylated AFP (AFP-L3) and des gamma-carboxy prothrombin (DCP) were measured at introducing Atez/Bev. Elevations of AFP (≥100 ng/ml), AFP-L3 (≥10%), and DCP (≥100 mAU/ml) were treated as positive, and the number of positive tumor marker was summed up and used as the previously proposed TM score. Hepatic reserve function was assessed with modified albumin-bilirubin grade (mALBI). Predictive values for prognosis were evaluated, retrospectively.
Results:
TM score 0 was in 81 (21.8%), score 1 in 110 (29.6%), score 2 in 112 (29.9%), and score 3 in 68 (18.3%), respectively. Median overall survival (OS) was not applicable [NA] (95% CI NA-NA), 24.0 months (95% CI 17.8-NA), 16.7 months (95% CI 17.8-NA) and NA (95%CI 8.3-NA) for TM scores 0, 1, 2 and 3, respectively (p<0.001). Median progression free survival (PFS) was also 16.5 months (95% CI 8.0-not applicable [NA]), 13.8 months (95% CI 10.6-21.3) and 7.7 months (95% CI 5.3-8.9), 5.8 months (95%CI 3.0-7.6), respectively (p<0.001). OS was stratified well in mALBI 1/2a as well as in mALBI 2a/2b. Whereas, PFS was well stratified in mALBI 2a/2b, while not in mALBI 1/2a.
Conclusion: The TM score was a simple and useful prognostic marker in HCC patients treated with Atez/Bev.
Functional Characteristics of Diverse PAX6 Mutations Associated With Isolated Foveal Hypoplasia
Authors: Matsushita Itsuka , Izumi Hiroto , Ueno Shinji , Hayashi Takaaki , Fujinami Kaoru , Tsunoda Kazushige , Iwata Takeshi , Kiuchi Yoshiaki , Kondo Hiroyuki
Published: June 2023

Autosomal dominant isolated foveal hypoplasia (FVH1) is a rare condition of foveal hypoplasia (FH) that lacks any other ocular manifestations. FVH1 is associated with hypomorphic mutations in the PAX6 gene. We report our findings in 17 patients with PAX6 mutations associated with FVH1 or FH with aniridia and corneal opacities. Patients with three mutations, p.V78E, p.V83F and p.R128H, in the C-terminal subdomain of the paired domain (CTS) consistently had severe FH. Luciferase assays indicated that the transcriptional activities of these mutations were significantly reduced comparable to that with truncation mutation of p.G65Rfs*5. Patients with p.P20S in the N-terminal subdomain of the paired domain, and a patient with p.N365K in the proline-serine-threonine-rich domain (PSTD) had mild FH. A patient with p.Q255L in the homeodomain had severe FH. The P20S and Q255L mutants did not affect the transcriptional activity. Mutant N365K had a retained DNA binding activity but a reduced transcriptional activity due to a low PSTD transactivation. These findings demonstrated that mutations associated with FVH1 underlie a functional divergence between DNA binding ability and transcriptional activity. Broadly distributed mutations in the PAX6 gene, not limited to the CST region, were responsible for FVH1.
Stripping Model for Short GRBs: the Impact of Nuclear Data
Authors: Yudin Andrey , Kramarev Nikita , Panov Igor , Ignatovskiy Anton
Published: June 2023

We investigate the impact of incoming nuclear data on the predictions of the neutron star (NS) stripping model for short gamma-ray bursts. The main area to which we pay attention is the NS crust. We show that the uncertain properties of the NS equation of state can significantly influence the stripping time tstr, the main dynamical parameter of the model. Based on the known time delay (tstr≈1.7s) between the peak of the gravitational wave signal GW170817 and the detection of gamma photons from GRB170817A, we obtain new restrictions on the nuclear matter parameters, in particular, the symmetry energy slope parameter: L<114.5MeV. In addition, we study the process of nucleosynthesis in the outer and inner crusts of a low-mass NS. We show that the nucleosynthesis is strongly influenced by both the incoming nuclear data and the equation of state of the NS matter.
Malaria Elimination in Africa: Rethinking Strategies for P. vivax and Lessons From Botswana
Authors: Quaye Isaac K. , Aleksenko Larysa , Paganotti Giacomo M. , Peloewetse Elias , Haiyambo Daniel H. , Ntebela Davies , Oeuvray Claude , Greco Beatrice
Published: June 2023

The global malaria community has picked up the theme of malaria elimination in greater than 90 % of the world’s population in the next decade. The recent reports of P. vivax in all sub-Saharan Africa, including Duffy negative individuals, threaten the efforts to achieve elimination. This is not only in view of strategies that are tailored only to P. falciparum elimination, but also due to currently revealed biological characteristics of P. vivax concerning the relapse patterns of hypnozoites and conservation of a large biomass at cryptic sites in the bone marrow and spleen. A typical scenario has been observed in Botswana from the period between 2008 to 2018, which palpably projects how P. vivax could endanger efforts at malaria elimination where the two parasites co-exist. The need for the global malaria community, NMPs, funding agencies and relevant stakeholders to engage in a forum to discuss and recommend clear pathways for sub-Saharan Africa regarding malaria elimination including P. vivax, is warranted.
Preeclampsia and the Antiphospholipid Syndrome
Authors: Mayer-Pickel Karoline , Nanda Manurishi , Gajic Maja , Cervar-Zivkovic Mila
Published: June 2023

Antiphospholipid syndrome (APS) is characterized by venous or arterial thrombosis and/or adverse pregnancy outcome in the presence of persistent laboratory evidence of antiphospholipid antibodies (aPL).
Preeclampsia (PE) complicates about 10-17% of pregnancies with APS. However, only early onset PE (< 34 weeks of gestation) belongs to the clinical criteria of APS.
The similarities in the pathophysiology of early onset PE and APS emphasize an association of these two syndromes. Overall, both are the result of a defective trophoblast invasion and decidual transformation at early gestation.
Women with APS are at increased risk for prematurity; the reasons are mostly iatrogenic due to placental dysfunction, such as PE or FGR.
Interestingly, women with APS have also an increased risk for preterm delivery, even in the absence of FGR and PE and therefore not indicated but spontaneous.
The basic treatment of APS in pregnancy is low-dose-aspirin and low-molecular- weight-heparin. Nevertheless, up to 20-30% of women develop complications at early and late gestation despite basic treatment. Several additional treatment options have been proposed, with Hydroxychloroquine (HCQ) being one of the most efficient.
Additionally, nutritional interventions, such as intake of vitamin D have shown promising beneficial effects. Curcumin, due to its antioxidant and anti-inflammatory properties, might be considered as additional intervention as well.
Antioxidants in a Morning Cup: Molecular Insights on Coffee Components
Authors: Hernández-Ayala Luis Felipe , Pérez-González Adriana , Reina Miguel , Guzmán-López Eduardo Gabriel , Galano Annia
Published: June 2023

Coffee is not only a delicious beverage but also an important dietary source of natural antioxidants. We live in an oxidative world where it is impossible to avoid pollution, stress, food additives, radiation, and other sources of oxidants that eventually lead to severe health disorders. Fortunately, there are chemicals in our diet that counteract the hazards posed by the reactive species that trigger oxidative stress. They are usually referred to as antioxidants; some of them can be versatile compounds that exert such a role in various ways. This review summarizes, from a chemical point of view, the antioxidant effects of relevant molecules found in coffee. Their ways of action and trends in activity are analyzed, considering the data gathered so far from both theory and experiments. The influence of the media and pH in aqueous solution, and structure-activity relationships are discussed. The protective role of the explored compounds is examined. A particular section is devoted to derivatives of some coffee components, and another one to their bioactivity. Hopefully, the information provided here will promote further investigations into the amazing chemistry contained in our morning cup.
Pattern Analysis of Galectin 1, 3, and 9 Serum Levels in Breast Cancer
Authors: Funkhouser Avery , Shuster Hayden , Martin Julie , Edenfield W. Jeffery , Blenda Anna
Published: June 2023

Galectins have been shown to have roles in cancer progression via contributions to angiogenesis, metastasis, cell division, and evasion of immune destruction. This study analyses galectin-1, -3, and -9 serum concentrations in breast cancer patients by enzyme-linked immunosorbent assay (ELISA) against the characteristics of the patient and tumor such as stage, molecular subtype, and receptor expression. Galectin-9 was found to be statistically significantly increased in HER2 enriched tumors as well as being reduced in patients with hormone receptor positive tumors and increased in patients with HER2 amplified tissues. Galectin-1 was found to be statistically significantly increased in the serum of patients who had undergone hormonal, immunotherapy, or chemotherapy. These findings provide insight as to the changes in galectin levels during cancer progress, response to treatment and molecular phenotype. These findings are valuable in the further understanding of the relationships of galectin and tumor biology and can inform future research on therapeutic targets for galectin inhibitors and the utility of galectin biomarkers.
Smartphone-Based Electrochemical Biosensor for On-Site Nutritional Quality Assessment of Coffee Blends
Authors: D’Agostino Cristine , Chillocci Claudia , Polli Francesca , Surace Luca , Simonetti Federica , Agostini Marco , Brutti Sergio , Mazzei Franco , Favero Gabriele , Zumpano Rosaceleste
Published: June 2023

This work aimed to develop an easy-to-use smartphone-based electrochemical biosensor to quickly assess coffee blend's total polyphenol (Phs) content at industrial and individual level. The device is based on a commercial carbon-based screen-printed electrode (SPE) modified with multi-walled carbon nanotubes (CNTs) and gold nanoparticles (GNPs). At the same time, the biotransducer, Laccase from Trametes versicolor, TvLac, was immobilized on the sensor surface by using glutaraldehyde (GA) as cross-linking agent. The platform was electrochemically characterized to ascertain the influence of the SPE surface modification on its performance. The working electrode (WE) surface morphology characterization was obtained by scanning electron microscopy (SEM) and Fourier-transform infrared (FT-IR) imaging. All the measurements were carried out with a micro-potentiostat Sensit Smart by PalmSens connected to a smartphone. The developed biosensor provided a sensitivity of 0.12 μA/μM, a linear response ranging from 5 to 70 μM, and a lower detection limit (LOD) of 2.99 μM. Afterwards, the biosensor was tested for quantifying the total Phs content in coffee blends, evaluating the influence of both the variety and the roasting degree. The smartphone-based electrochemical biosensor performance has been validated though the Folin-Ciocâlteu standard method.
Multi-sensor Based Occupancy Prediction in a Multi-zone Office
Building with Transformer
Authors: Qaisar Irfan , Sun Kailai , Zhao Qianchuan , Xing Tian , Yan Hu
Published: June 2023

Buildings are responsible for approximately 40% of the world’s energy consumption and 36% of the total carbon dioxide emissions. Building occupancy is essential, enabling Occupant-Centric Control for zero emissions and decarbonization. Although existing machine learning and deep learning methods for building occupancy prediction have achieved remarked progress, their analyses remain limited when applied to complex real-world scenarios. Besides, there is a high expectation for Transformer algorithms to predict building occupancy accurately. Therefore, this paper presents an Occupancy Prediction Transformer network (OPTnet). We fuse and feed multi-sensor data (building occupancy, indoor environmental conditions, HVAC operations) into a Transformer model to forecast the future occupancy presence in multiple zones. We perform experimental analysis and compare it to different occupancy prediction methods (e.g., Decision Tree, Long Short-Term Memory networks, Multi-layer perceptron) and diverse time horizons (1,2,3,5,10,20,30mins). The performance metrics (e.g., Accuracy and Mean Squared Error) are employed to evaluate the effectiveness of prediction algorithms. Our OPTnet method achieves superior performance on our experimental two-week data compared to existing methods. The improved performance signifies its potential to enhance HVAC control systems and energy optimization strategies. We will make the code publicly available at https://github.com/kailaisun/occupancy-prediction-binary to promote transparency and reproducibility.
HCS-Splice: A High-Content Screening Method to Advance the Discovery of RNA Splicing-Modulating Therapeutics
Authors: Covello Giuseppina , Siva Kavitha , Adami Valentina , Denti Michela Alessandra
Published: June 2023

Nucleic acid therapeutics are witnessing an impressive acceleration in recent years. They work through multiple mechanisms of action, including downregulation of gene expression and modulation of RNA splicing. While several drugs based on the former mechanism have been approved, few target the latter, despite the promise of RNA splicing modulation. To improve our ability to discover novel RNA splicing-modulating therapies, we developed HCS-Splice, a robust cell-based High-Content Screening (HCS) assay. By implementing the use of a two-colour (GFP/RFP) fluorescent splicing reporter plasmid, we developed a versatile, effective, rapid, and robust high-throughput strategy for the identification of potent splicing-modulating molecules. The HCS-Splice strategy can also be used to functionally confirm splicing mutations in human genetic disorders or to screen drug candidates. As a proof-of-concept, we introduced a dementia-related splice-switching mutation in Microtubule-Associated Protein Tau (MAPT) exon 10 splicing reporter. We applied HCS-Splice to the wild-type and mutant reporters and measured the functional change in exon 10 inclusion. To demonstrate the applicability of the method to cell-based drug discovery, HCS-Splice was used to evaluate the efficacy of an exon 10-targeting siRNA, which was able to restore the correct alternative splicing balance.
A Genetic Algorithms Enhanced Sensor Marks Selection Algorithm For Advanced Photolithography Process
Authors: Magklaras Aris , Panagiotis Alefragkis , Gogos Christos , Valouxis Christos , Birbas Alexios
Published: June 2023

In photolithography process, nanometer level precise, wavefront aberration models enable the machine to be able to meet the overlay (OVL) drift and critical dimension (CD) specifications. Software control algorithms take as input these models and correct any expected wavefront imperfections before reaching the wafer. In such way a near optimal image is exposed on the wafer surface. Optimizing the parameters of these models though, involves several time costly sensor measurements which reduce the throughput performance, in terms of exposed wafers per hour, of the machine. In that case, photolithography machines come across the trade-off between throughput and quality. Therefore one of the most common Optimal Experimental Design (OED) problems in photolithography machines (and not only) is how to choose the minimum amount of sensor measurements that will provide the maximum amount of information. Additionally, each sensor measurement corresponds to a point on the wafer surface and therefore we must measure uniformly around the wafer surface as well. In order to solve this problem, we propose a Sensor Marks Selection Algorithm which exploits Genetic Algorithms. The proposed solution first selects a pool of points that qualify as candidates to be selected in order to meet the uniformity constraint. Then, the point that provides the maximum amount of information, quantified by the Fisher based criteria of G, D and A-Optimality, is selected and added to the measurement scheme. This process though is considered "greedy", and for this reason Genetic Algorithms (GA) are exploited to further improve the solution. By repeating in parallel the "greedy" part several times we get an initial population that will be the input to our GA. This meta-heuristic approach outperforms the "greedy" approach significantly. The proposed solution is applied in a real life semiconductors industry use case and achieves interesting industry and academical results as well.
Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and are Predictive of Response in Locally Advanced Rectal Cancer
Authors: Lim Stephanie H , Chua Wei , Ng Weng , Ip Emilia , Marques Tania M , Tran Nham T , Gama-Carvalho Margarida , Asghari Ray , Henderson Christopher , Ma Yafeng , De Souza Paul , Spring Kevin J.
Published: June 2023

Locally advanced rectal cancer (LARC) has traditionally been treated with trimodality therapy consisting of neoadjuvant radiation +/- chemotherapy, surgery and adjuvant chemotherapy. There is currently a clinical need for biomarkers to predict treatment response and outcomes, especially during neoadjuvant therapy. Liquid biopsy in the form of circulating tumour cells (CTCs) and circulating nucleic acids in particular microRNAs (miRNA) are novel, highly stable and clinically relevant regulators of disease. We studied a prospective cohort of 52 patients with LARC, and obtained samples at baseline, during treatment, and post-treatment. We enumerated CTCs during chemoradiation at these three time-points, using the IsofluxTM CTC Isolation and detection platform. We then subjected the isolated CTCs to miRNA expression analyses, using a panel of 106 miRNA candidates. We identified CTCs in 73% of patients at baseline, and numbers fell during treatment and miRNA expression profiles also changed during treatment. Between baseline and during treatment (week 3) time-points three microRNAs (hsa-miR-95, hsa-miR-10a and hsa-miR-16-1*) were highly differentially expressed. Importantly, hsa-miR-19b-3p and hsa-miR-483-5p were found to correlate with good response to treatment. The latter (hsa-miR-483-5p) was also found to be differentially expressed between good responders and poor responders. They represent potential predictive biomarkers and a potential miRNA-based treatment strategy. In this study, we demonstrate that CTCs are present and can be isolated in the non-metastatic early stage cancer setting, and their associated miRNA profiles can potentially be utilized to predict treatment response.
The Application of Tunable Magnetic Devices in Electrical Power Systems with Adaptive Feature
Authors: Gwóźdź Michał
Published: June 2023

The work focuses on the possibility of application of tunable magnetic devices in electrical power systems with adaptive features. The idea underlying this type of operation, which depends on interaction with magnetic fluxes in a quassi-linear range of magnetic core characteristics, is a new approach to the design of magnetic elements. The suitable examples of adaptive electrical power systems can be devices for improving the quality of electricity. When used in compensators of reactive power or both reactive and distortion power, tunable magnetic devices offer much wider possibilities for the compensation, compared to “standard“ solutions, involving compensators based on fixed inductors. Nevertheless, the application of the proposed device in electrical systems such as is only an example of its possible implementations in the area of electrical power. In this work the following issues are covered: exemplary solution of an adaptive ‘passive’ compensator, rules for the operation of tunable magnetic device, and results investigation of the laboratory model of an electrical system based on such device.
Hypersensitivity Test of Insect-Carried Bacteria in Chilli Crop at Banyumas Regency
Authors: Suroto Agus , Mugiastuti Endang , Tarjoko Tarjoko , Oktaviani Eka , Bahrudin Muhammad
Published: June 2023

As a horticultural crop with high economic and cultural values, the productivity of chili (Capsicum annum L.) fluctuates from time to time. This is influenced by changes in weather and climate which lead to the low resistance of chili plants to pests and diseases. Climate change can affect the existence of pests and diseases in plants and even reduce yields between 10-28% on a global scale. Bacteria, in association with plants, can be both pathogenic and non-pathogenic. While pests tend to have a negative relationship with plants because they can cause damage to plants. Banyumas Regency (Central Java) is one of the districts that contribute to the supply of chili which is important to increase production. This study aims to distinguish pathogenic and non-pathogenic bacteria, which are carried by insects in chili planting fields in 3 (three) endemic locations for pest attacks, namely Sumbang, Sokaraja, and Karanglewas Districts. The research was conducted from March to November 2021. As many as 83.33% of the total grown isolates did not show hypersensitive reactions while the others showed positive results. However, further research needs to be carried out for further research (characterization, identification, and other potential of the isolated insect-borne bacteria).
Research on a Typical Casing Failure during Drilling of Cement Plugs in Ultradeep Wells
Authors: Ding Liangliang , Chen Wenkang , Han Chuanjun , Geng Hailong , Zhang Qiang
Published: June 2023

Among the casing failures in 46 ultradeep wells in a particular block, 11 ultradeep wells had the same casing failure forms occur during the drilling of cement plugs. The casing failure forms are local bending deformation and local internal pressure damage, which eventually led to a local burst failure of the casing in the 11 typical ultradeep wells. Therefore, a casing strength checking model is established to investigate the primary reasons for the local burst failure of the casing and the local burst failure mechanism of the casing. A case study is performed on casing in typical ultradeep wells with force conditions to evaluate the safety state of the casing and make necessary recommendations to improve its safety. The obtained results indicate that an abnormally high dogleg (AHD), a decrease in the temperature at the bottom of the casing, and an annulus trap space are the characteristics of typical ultradeep wells, and the local burst failure of the casing is caused by the coupled superposition impact of a decrease in the annulus pressure buildup (APB), the casing temperature effect, and the magnification effect of the casing bending stress. The safety factor of the casing can be increased by changing the operation parameters and the material properties of the casing. To address the casing failure problems during the drilling of cement plugs in typical ultradeep wells, the protection and monitoring of the seal quality of the cement sheath should be improved to avoid expansion of the well diameter and formation of the annulus trap space. The casing strength and the injection temperature of the drilling fluid can be increased, and the drilling fluid displacement can be decreased.
Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer
Authors: Zhang Yonghui , Du Tongde , Liu Na , Wang Juan , Zhang Lingqiang , Li Chaonan , Zhang Xin , Wu Bo , Zhang Jinghao , Cui Chun-Ping , Li Hongchang , Jiang Wenli , Zhang Yubing , Zhang Yuting , Li Peiyu
Published: June 2023

The ubiquitin-proteasome system (UPS) controls protein turnover, and its dysfunction contributes to human diseases including cancer. Deubiquitinating enzymes (DUBs) remove ubiquitin from proteins to maintain their stability. Inhibition of DUBs could induce the degradation of selected oncoproteins and has therefore become a potential therapeutic strategy for cancer. The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer. Here, we report a small-molecule inhibitor of OTUD3 (named OTUDin3) by computer-aided virtual screening and biological experimental verification. OTUDin3 exhibited pronounced antiproliferative and proapoptotic effects by inhibiting deubiquitinating activity of OTUD3 in non-small-cell lung cancer (NSCLC) cell lines. Moreover, OTUDin3 efficaciously inhibited growth of lung cancer xenografts in mice. In summary, our results support OTUDin3 as a potent inhibitor of OTUD3, the inhibition of which may be a promising therapeutic strategy for NSCLC.
Comparison of 2-octyl Cyanoacrylate and N-octyl Cyanoacrylate Topical Skin Adhesives for Wound Closure after Ankle Fracture Surgery: A Prospective Randomized Trial
Authors: Park Young Hwan , Son Sei Wool , Han Sang Roc , Kim Hak Jun
Published: June 2023

To date, only a few clinical studies have investigated the differences between 2-octyl cyanoacrylate and n-octyl cyanoacrylate topical skin adhesives (TSAs). This study aimed to compare the outcomes of the two TSAs for wound closure after ankle fracture surgeries. Fifty-six patients were randomized to receive either a 2-octyl or n-octyl cyanoacrylate TSA. At 3 and 6 months after surgery, wound cosmetic outcomes were assessed using the Hollander wound evaluation scale (HWES), and patient satisfaction for wound cosmesis was assessed using the visual analog scale (VAS) and 5-item Likert scale. Functional outcomes at 6 months after surgery were assessed using the Olerud–Molander ankle score (OMAS). Fifty-five patients completed the study protocol. Within the follow-up period, no differences were found between the two groups in terms of HWES, VAS, 5-item Likert scale, and OMAS. 2-octyl cyanoacrylate TSA and n-octyl cyanoacrylate TSA were comparable options for wound closure after ankle fracture surgeries in terms of wound cosmesis, patient satisfaction, and functional outcome.
A 3-Layered Nonlinear Process Monitoring Strategy with a Novel Fault Diagnosis Approach
Authors: Mishra Bhagwan Kumar , Das Anupam
Published: June 2023

The article proposes the development of a layered process monitoring strategy based on Multi- Block Kernel Principal Component Analysis (MBKPCA). MBKPCA aids in the development of a distributed process monitoring strategy by taking into account the nonlinear relationships existing amongst the measured characteristics. A distributed process monitoring strategy stratifies the proposed process into a multi-layered structure comprising of blocks, sub-blocks etc. In this article an MBKPCA based monitoring strategy was devised for a Wire Rod Manufacturing Facility (WRMF) of an Integrated Steel Plant (ISP). The proposed monitoring strategy stratified the entire process into 3 layers, with the first layer comprising the manufacturing stages, the next layer comprising the sub-stages and the third layer comprising the characteristics to be monitored within the respective sub-stages. The detection of the fault was carried out with the aid of Kernel Principal Component Analysis (KPCA) score based Hotelling T2 chart. Fault detection was followed by Fault Diagnosis, for which new Fault Diagnostic Statistics were proposed which took into account the contribution of the main and the auxiliary characteristics. The study also proposed the concept of Cumulative Percent Contribution Ratio (CPCR) to limit the number of parameters (stages/sub-stages/characteristics) that needs to be retained in fault diagnosis.
Evaluation of graded recession of inferior oblique muscle for correction of different grades of V-pattern strabismus
Authors: sokeer Shaimaa H. , Ali Ahmed L. , Arafa El Sayed S. , Awara Amr M. , Shafik Heba M.
Published: June 2023

Background: V pattern identification is essential for a proper surgical management. Graded recession is a very logical approach to treat inferior oblique overaction (IOOA). The aim is to evaluate the efficacy of graded recession of inferior oblique muscle for correction of different grades of V pattern.
Methods:
Forty patients from 3 to 18 years old with V pattern strabismus and primary IOOA were evaluated by prism cover test to assess the grade of IOOA and amplitude of V-pattern. Graded recession of IO muscle depends on the amplitude of the V-pattern and degree of IOOA. Eight mm recession for amplitude 7.5° to 10° and mild IOOA (10° or +1) ,10 mm recession for amplitude 11°- 15° and moderate IOOA (11° -15 °or +2) and maximum recession for amplitude more than 15 °and marked IOOA (³ 15 ° or +3). Simultaneous correction of the horizontal deviation was performed. Follow up after I week,1 month ,3 month and 6-month.
Results:
The mean age of the study patients was 9 ± 4.261. Twenty patients (50%) had V-pattern esotropia, 12 (30%) exotropia, 4 (10%) orthotropic and four (10%) had Dissociated vertical deviation (DVD). Four cases 10% were of grade 1, 20 cases 50% grade 2 and 16 cases 40% were of grade 3. Of eighty eyes, 66 eyes 82.5% were fully corrected with no residual IOOA, and 14 eyes 17.5% were under corrected. V-pattern was corrected in 28 cases 70% and only 12cases 30% had residual V-pattern grade 1.
Conclusions:
Graded Recession of IO muscle is an effective technique for eliminating IOOA and can be graded according to the grade of IOOA, 8-mm recession for +1 overaction, 10-mm for +2 overaction, and 14-mm (maximum recession) for +3 overaction. The grade of IOOA correlates with the amplitude of V-pattern. The amount of recession correlates with preoperative IOOA and grade of V-pattern with frequent undercorrections obtained by the standard 8 mm recession. A +2 overaction merits a 10-mm recession of the inferior oblique. A +3 or +4 overaction merits a 14-mm maximal recession.
Clinical features and change in incidence of acute acquired comitant esotropia: a 15-year single-center study in South Korea
Authors: Kim Ju Mi , Shin Jeonghwa , Lee Young Ho , Lee Yeon-Hee
Published: June 2023

Background/Objectives: We investigated the clinical features and change in incidence of AACE in South Korea.Subjects/Methods: This study reviewed the medical records of new patients who visited the Strabismus and Pediatric Ophthalmology Clinic (clinic of YHL) from January 1, 2007, to December 31, 2021. Patients with AACE or intermittent exotropia (IXT) were eligible for inclusion in the study. Clinical features were retrieved, including age at onset, angle of deviation, refractive errors, neuroimaging findings, and treatment outcomes. For each year, the proportion of new AACE patients among all new patients who visited the clinic, and the ratio of new AACE patients to new intermittent exotropia (IXT) patients, were analyzed to estimate the incidence of AACE.Results Overall, 59 patients were included in the study. The mean age of the patients was 24.7 ± 9.3 years; the incidence of AACE was highest in teenagers and young adults. The proportion of new AACE among all new patients showed increasing trend and it was statistically significant. (Linear regression analysis, R2 = 0.778, p < 0.001). There was also a significantly increasing trend in the ratio of new AACE patients to new IXT patients (R2 = 0.803, p < 0.001).Conclusions A new type of AACE, distinct from the classic types, is increasingly common in South Korea; this increasing incidence also appears to be a global phenomenon. Large-scale investigations are needed to define the exact clinical features, incidence, and pathophysiology of this new type of AACE.