bluuebunny/crossref_metadata_2025 huggingface dataset:
КУЛЬТУРОТВОРЧИЙ ПОТЕНЦІАЛ ВИКОНАВСЬКОЇ ДІЯЛЬНОСТІ ПРОФЕСОРА Є. БОГОСЛОВСЬКОГО
Authors: Badalov Oleg
Published: April 2023

Мета статті – вивчення виконавської діяльності Є. Богословського як піаніста-соліста, концертмейстера та організатора культурно-просвітницьких заходів у контексті культуротворчих процесів кінця ХІХ – першої третини ХХ століть, зокрема на Чернігівщині. Методологію дослідження складають історико-хронологічний метод – для з’ясування хронотопу виконавської діяльності митця; джерелознавчий та логіко-узагальнюючий – для опрацювання архівних фондів Є. Богословського, вивчення друкованих видань з метою формування джерельної бази дослідження та систематизації отриманих результатів. Наукова новизна статті полягає у введенні до наукового обігу невідомих архівних матеріалів, на підґрунті яких вперше досліджено виконавську діяльність Є. Богословського, як чинник культуротворення та форму взаємодії митця із соціумом. Висновки. Доведено значний культуротворчий потенціал виконавської діяльності Є. Богословського, що спричинила появу та розвиток мистецьких феноменів кінця XIX – першої третини ХХ ст. як на Чернігівщині, так і за її межами. Завдяки співпраці з Керзінським гуртком і «Будинком Пісні», митець брав участь у реалізації двох напрямків музичного просвітництва: змістовному та формотворчому. З’ясовано, що важливим чинником розвитку культурного простору Чернігівщини, де Є. Богословський у 1896–1935 рр. виконував функції безумовного лідера, стало створення ним лекцій-концертів просвітницького спрямування. Участь у цих заходах чернігівських музикантів поряд зі столичними артистами підвищувала мистецький рівень творчих сил регіону, що вплинуло на професіоналізацію музичного руху Чернігівщини (заснування музичних класів, музичного училища) та пожвавило концертну роботу. Значний культуротворчий потенціал, закладений Є. Богословським на Чернігівщині напередодні Другої світової війни, обумовив швидке відродження музичного життя регіону у повоєнні роки, завдяки діяльності його учнів.
ДУЕТИ ДЛЯ ЯНЦИНЯ ТА ФОРТЕПІАНО В СУЧАСНІЙ КИТАЙСЬКІЙ МУЗИЦІ: ТЕОРЕТИКО-ВИКОНАВСЬКИЙ ПОГЛЯД
Authors: Xiaoxi Liu
Published: April 2023

У статті розглянуто особливості дуетів для янциня та фортепіано сучасних китайських композиторів Ван Се та Ван Даньхуна. Визначено, що камерно-інструментальна творчість є відносно новою жанровою нішею в китайській музиці. Встановлено, що подібне сполучення китайських традиційних тембрів з фортепіано демонструє синтез ознак західної та східної музики, що призводить до оригінальних результатів. Мета статті полягає у виявленні жанрово-стилістичних, структурних та виконавських особливостей творів «Падаючі квіти. Ніч» Ван Се та Рапсодії Ван Даньху в контексті проблем сучасної китайської камерно-фортепіанної музичної творчості. Методологія дослідження поєднує системний підхід (при вивченні творів китайських композиторів як частини жанрового поля світової камерної музики), метод смислового аналізу музичного тексту (при визначенні сталих семантичних одиниць тексту творів), структурно-функціональний аналіз (вивчення творів з точки зору композиційної цілісності) та метод аналізу інтерпретаційних версій. Наукова новизна статті полягає у введенні до музикознавчого обігу музичних творів, що раніше не вивчалися, та у визначенні композиційних та смислових особливостей дуетів для фортепіано з традиційними народними інструментами китайських авторів. Висновки. Створюючи дуети для янциня та фортепіано, китайські композитори намагаються знайти індивідуальну творчу стратегію. Працюючи з урахуванням новітніх тенденцій світової музики, китайські композитори залишаються вірними національним традиціям. Незважаючи на те, що їхні твори зазнають впливу сучасних технік композиції (полістилістика, мінімалізм, оригінальні прийоми звуковидобування) та вписуються в поле західних культурно-естетичних принципів, вони не поступаються інтонаційним та композиційним зв’язком з традиційною китайською музикою. Таким чином композиторам вдається створювати камерно-інструментальні дуети, в яких наявною є ідея стильового синтезу, що дозволяє їм посідати чинне місце у світовому концертному просторі.
ВОКАЛЬНИЙ ЦИКЛ Е. ШОССОНА НА ВІРШІ М. МЕТЕРЛІНКА «ТЕПЛИЦІ»: ВЗАЄМОДІЯ ХУДОЖНІХ СВІТІВ
Authors: Milanina Alyona
Published: April 2023

Вокальна лірика – це той жанр, якому Ернест Шоссон довіряє свої найбільш інтимні і глибокі переживання. В його творчості музика покликана виражати душевний світ людини і очищати людські душі співчуттям. Слово – носій ідеї, думки, яку наповнює почуттям музика. Музика вступає в тісний союз з поезією, при цьому, якість, як і змістовність поезії, відіграють вирішальну роль у її виборі. Вокально-поетичний цикл «Теплиці» видатних митців Е. Шоссона - М. Метерлінка максимально насичений символікою, що проймає як вербальні, так і музичні ряди, завдяки чому виникає своєрідний живописно-поетично-музичний код, або правила трансформації значень та сенсів у знаки, які ми прочитуємо як меседж авторів (поетів та композитора), що створили подібні тексти. Тому мета наукової статті – розкрити механізми взаємодії музичних, вербальних, візуальних складових у прогресі їх синтезу в композиції «Теплиці». Методи презентованого наукового дослідження: інтермедіальний, семіотичний, компаративний та структурно-функціональний. Наукова новизна – вперше методологія і методика інтермедіального аналізу використовується на матеріалі відомого вокального циклу Е. Шоссона «Теплиці». Висновки. У добре знаному вокальному циклі «Теплиці» Е. Шоссон та М. Метерлінк художньо виразно висвітлена природа людського стану за допомогою символізму в поезії, музиці та кольорі. У репрезентованій науковій роботі представлена кольорова гама твору, з якої стає абсолютно зрозуміло як поступово змінюється настрій головного героя композиції: від одухотвореної надії на краще (№ 1, № 2) через розчарування та відчай (№ 3, № 4) до покори та безмежного сподівання на Бога. У дослідженні наголошується, що для поета й композитора символізм стає тим винятково унікальним «інструментом» мистецтва, який в завуальованій формі максимально точно репрезентує екзистенційні глибини людської душі.
Comparative Analysis of Root System Architectural Traits In Genotypes of Vigna Radiata L. And Vigna Mungo L.
Authors: Ravi Prakash Reddy Bana Venkata , Dikshit Harsh Kumar , Aski Muraleedhar S , Mishra Gyan Prakash
Published: April 2023

Investigation of root system architecture (RSA) has a huge potential to support the crop improvement under suboptimal nutrient and water conditions. The present study was carried out using eight genotypes of each mungbean and urdbean for comparative analysis of RSA traits among the genotypes. Presence of significant variations and medium to high heritability was observed for RSA traits. The genotypes KM 12-29 followed by PUSA 9072 among the mungbean genotypes and LBG 623 followed by PU 11-14 among the urdbean genotypes showed higher proportion of RSA traits. The higher percentage distribution of root traits was observed under diameter intervals in the order of 0-0.5 > 0.5-1.0 > 1.0-1.5 > 1.5-2.0 >> 2.0 mm in both mungbean and urdbean genotypes. Thus, the study shows the clear depiction and comparison of RSA traits among mungbean and urdbean genotypes, which can be exploited for cultivar development in future breeding programmes.
Bangladesh J. Bot. 52(1): 61-69, 2023 (March)
Effects of Different Irrigation Regimes and Genotypes on Yield Contributing Parameters of Potato (Solanum Tuberosum L.) Under Chhattisgarh, India
Authors: Rangare Smita Bala , Rangare NR , Patel Deepti , Singh Uma
Published: April 2023

The field experiment was conducted at the Horticultural Research Farm, College of Agriculture, Indira Gandhi Krishi Vishwavidyalaya, Raipur, Chhattisgarh, India during Rabi 2018-19 in Split plot Design with four level of irrigation regimes and four potato genotypes. The irrigation treatments were allotted in the main plot while, potato genotypes allotted in the sub-plots. At 75 days after planting (DAP) and 90 days after planting (DAP), the various yield contributing parameters were affected significantly by the different irrigation regimes except the plant emergence and number of shoots/plant. The number of shoots/plant, number of total leaves/plant, fresh weight of tubers/plant (g), total number of tuber/plant and harvest index (%) were significantly affected by the different irrigation regimes and potato genotypes. The plant with irrigation at 25 mm cumulative pan evaporation (CPE) produced the maximum plant height, number of shoots/plant, number of total leaves/plant, number of tubers/plant, fresh weight/plant and harvest index at 75 DAP and 90 DAP, respectively. The potato genotype AICRP-P-38 gave the highest fresh weight of tuber/ plant, number of tubers/plant and harvest index at 75 DAP and 90 DAP, respectively.
Bangladesh J. Bot. 52(1): 211-216, 2023 (March)
Mapeamento Cartográfico das Pesquisas em Biotecnologia apresentadas no ENPEC
Authors: Ernst Daniela Carolina , Santos Marlene Guevara dos , Maciel Fábio Luís , Kern Ana Lúcia , Costa Carolina Farias da , Mallmann Maria Carolina Ernst , Loeser Bruna Gabrielle
Published: April 2023

A biotecnologia está cada vez mais presente entre os cotidianos e oferece várias possibilidades de aplicação em nossas vidas. Torna-se imperativo entender como ela está sendo abordada na Educação Científica. O presente trabalho busca compreender os âmbitos que envolvem as pesquisas em Biotecnologia apresentadas no Encontro Nacional de Pesquisa em Ensino de Ciências (ENPEC) revisando desde sua primeira edição em 1997, o que totalizam 11 edições do evento. Para o levantamento foi considerada a palavra Biotecnologia entendo sua complexidade e a processualidade que lhe são inerentes. Defendemos a abordagem dos modos de transição, intervocálicos e intermediários, tendo a cartografia como uma perspectiva rizomática e possibilidade de operador metodológico. As publicações foram exploradas através de linhas que perpassaram os títulos, palavras-chave e os resumos, de forma a acompanhar os fluxos de trabalhos publicados no ENPEC que relacionam o tema da Biotecnologia. Organizamos nosso mapa de informações por ano de publicações; programas de pós-graduação estão pesquisando/escrevendo sobre o tema e autoria. Constatamos com preocupação que o tema é incipiente na área, tendo número reduzido de 10 trabalhos que abordaram a biotecnologia. Defendemos assim, que mais pesquisas são necessárias para investigar e divulgar suas possibilidades para discutir incertezas científicas e interdisciplinaridade no Ensino de Ciências.
Assistência de enfermagem no transporte intra-hospitalar do paciente grave: recomendações legais frente às evidências atuais
Authors: Santos Douglas Vargas dos , Claudino Wendel Oroski , Gonçalves Roberto Leonardo , Puerari Rodrigo , Pola Paula dos Santos
Published: April 2023

Objetivo: Este estudo teve como objetivo descrever o transporte intra-hospitalar como prática de ação de continuidade aos cuidados intensivos ao paciente, relacionando-as às atividades desempenhadas pelo enfermeiro. Métodos: Trata-se de um estudo de revisão integrativa, com busca nas bases de dados LILACS, BDEnf e SciELO. Foram analisados sete artigos na íntegra onde se pôde evidenciar que com o planejamento prévio das etapas do transporte intra-hospitalar torna-se possível minimizar o impacto dos eventos adversos ao paciente transportado em conformidade com a resolução no 376/2011COFEN. Conclusão: Nos estudos analisados não foram encontradas referencias especificas quanto à atuação do Enfermeiro durante o processo do transporte propriamente dito. É necessário que novos estudos sejam realizados a fim de validar na prática a real função do enfermeiro e a importância de sua presença durante todas as etapas complexas e minuciosas que envolvem o transporte intra-hospitalar de forma a contribuir para a qualidade na assistência e segurança do paciente.
HYDROGELS: ONE STOP SOLUTION FOR WATER SCARCITY
Authors:   UAS, Dharwad, KN, Kumar Behera Alok , Patnaik Subhashree , Ranjan Behera Soumya ,   JNKVV, Jabalpur, MP,   PSBVB, Bolpur, WB
Published: April 2023

The growing world is leading to face many unavoidable problems like poverty, climate change, pollution, pandemic etc. Due to increase in the green house gases we could see the melting of ice in Green Island. GHGs entrap the long wave reflected radiations which leads to the increase in the global temperature. Due to this, we could observe the erratic rain fall patterns which cause water scarcity and drought. Consequent crop loss is observed in the arid and semiarid regions due to scanty rainfall in the recent years. So, there is a need of alternative means to conserve the water and to improve water use efficiency (WUE). The topic of super absorbent hydrogels comes in here to bridge the gap. These are having swelling property which holds a huge of amount of water and supplies water and nutrient for a prolonged period of time to the crop roots. In this chapter, the use and importance of hydrogels are well presented and detected clearly for the better understanding.
Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions
Authors: Weggen Jan Tobias , Seidel Janik , Bean Ryan , Wendeler Michaela , Hubbuch Jürgen
Published: April 2023

The manufacturing of antibody-drug conjugates (ADCs) involves the addition of a cytotoxic small-molecule linker-drug (= payload) to a solution of functionalized antibodies. For the development of robust conjugation processes, initially small-scale reaction tubes are used which requires a lot of manual handling. Scale-up to larger reaction vessels is often knowledge-driven and scale-comparability is solely assessed based on final product quality which does not account for the dynamics of the reaction. In addition, information about the influence of process parameters, such as stirrer speed, temperature, or payload addition rates, is limited due to high material costs. Given these limitations, there is a need for a modeling-based approach to investigate conjugation scale-up. In this work, both experimental kinetic studies and computational fluid dynamics (CFD) conjugation simulations were performed to understand the influence of scale and mixing parameters. In the experimental part, conjugation kinetics in small-scale reaction tubes with different mixing types were investigated for two ADC systems and compared to larger bench-scale reactions. It was demonstrated that more robust kinetics can be achieved through internal stirrer mixing instead of external mixing devices, such as orbital shakers. In the simulation part, 3D-reactor models were created by coupling CFD-models for three large-scale reaction vessels with a kinetic model for a site-specific conjugation reaction. This enabled to study the kinetics in different vessels, as well as the effect of process parameter variations in silico. Overall, it was found that for this conjugation type sufficient mixing can be achieved at all scales and the studied parameters cause only deviations during the payload addition period. An additional time-scale analysis demonstrated to aid the assessment of mixing effects during ADC process scale-up when mixing times and kinetic rates are known. In summary, this work highlights the benefit of kinetic models for enhanced conjugation process understanding without the need for large-scale experiments.
Free-aldehyde neutralized and oligohyaluronan loaded bovine pericardium with improved anti-calcification and endothelialization for bioprosthetic heart valves
Authors: Liu Yuhong , Chen Chunyang , Lu Ting , Liu Sixi , Wu Zhongshi , Tang Zhenjie
Published: April 2023

The number of patients with valvular heart disease is increasing yearly, and valve replacement is the most effective treatment, during which bioprosthetic heart valves (BHVs) are the most widely used. Commercial BHVs are mainly prepared with glutaraldehyde (Glut) cross-linked bovine pericardial or porcine aortic valves, but the residual free aldehyde groups in these tissues can cause calcification and cytotoxicity. Moreover, insufficient glycosaminoglycans (GAGs) in tissues can further reduce biocompatibility and durability. However, the anti-calcification performance and biocompatibility might be improved by blocking the free aldehyde groups and increasing the GAGs content in Glut-crosslinked tissues. In our study, adipic dihydrazide (ADH) was used to neutralize the residual free aldehyde groups in tissues and provide sites to blind with oligohyaluronan (OHA) to increase the content of GAGs in tissues. The modified bovine pericardium was evaluated for its content of residual aldehyde groups, the amount of OHA loaded, physical/chemical characteristics, biomechanical properties, biocompatibility, and in vivo anticalcification assay and endothelialization effects in juvenile Sprague-Dawley rats. The results showed that ADH could completely neutralize the free aldehyde groups in the Glut-crosslinked bovine pericardium, the amount of OHA loaded increased and the cytotoxicity was reduced. Moreover, the in vivo results also showed that the level of calcification and inflammatory response in the modified pericardial tissue was significantly reduced in a rat subcutaneous implantation model, and the results from the rat abdominal aorta vascular patch repair model further demonstrated the improved capability of the modified pericardial tissues for endothelialization. Furthermore, more α-SMA+ smooth muscle cells and fewer CD68+ macrophages infiltrated in the neointima of the modified pericardial patch. In summary, blocking free-aldehydes and loading OHA improved the anti-calcification, anti-inflammation and endothelialization properties of Glut-crosslinked BHVs and in particularly, this modified strategy may be a promising candidate for the next-generation of BHVs.
Efficacy of left subclavian artery revascularization strategies during thoracic endovascular aortic repair in patients with type B dissection: A single-center experience of 105 patients
Authors: Wu Xiangyang , Li Yongnan , Zhao Yinglu , Zhu Yilin , Wang Shixiong , Ma Qi , Liu Debin , Gao Bingren , Wei Shilin , Wang Weifan
Published: April 2023

Background

Left subclavian artery (LSA) revascularization during thoracic endovascular aortic repair (TEVAR) is necessary to reduce postoperative complications in patients with Stanford type B aortic dissection and an insufficient proximal anchoring area. However, the efficacy and safety of different LSA revascularization strategies remain unclear. Here, we compared these strategies to provide a clinical basis for selecting an appropriate LSA revascularization method.

Methods

In this study, we included 105 patients with type B aortic dissection who were treated using TEVAR combined with LSA reconstruction in the Second Hospital of Lanzhou University from March 2013 to 2020. They were divided into four groups according to the method used for LSA reconstruction, namely, carotid subclavian bypass (CSB; n = 41), chimney graft (CG; n = 29), single-branched stent graft (SBSG; n = 21), and physician-made fenestration (PMF; n = 14) groups. Finally, we collected and analyzed the baseline, perioperative, operative, postoperative, and follow-up data of the patients.

Results

The treatment success rate was 100% in all the groups, and CSB + TEVAR was the most commonly used procedure in emergency settings compared with the other three procedures (P < 0.05). The estimated blood loss, contrast agent volume, fluoroscopic time, operation time, and limb ischemia symptoms during the follow-up were significantly different in the four groups (P < 0.05). Pairwise comparison among groups indicated that the estimated blood loss and operation time in the CSB group were the highest (adjusted P < 0.0083; P < 0.05). The contrast agent volume and fluoroscopy duration were the highest in the SBSG groups, followed by PMF, CG, and CSB groups. The incidence of limb ischemia symptoms was the highest in the PMF group (28.6%) during the follow-up. The incidence of complications (except limb ischemia symptoms) during the perioperative and follow-up periods was similar among the four groups (P > 0.05) The median follow-up time of CSB, CG, SBSG, and PMF groups was significantly different (P < 0.05), and the CSB group had the longest follow-up.

Conclusion

Our single-center experience suggested that the PMF technique increased the risk of limb ischemia symptoms. The other three strategies effectively and safely restored LSA perfusion in patients with type B aortic dissection and had comparable complications. Overall, different LSA revascularization techniques have their advantages and disadvantages.
Evaluation of early left-sided cardiac reverse remodeling under combined therapy of sacubitril-valsartan and spironolactone compared with angiotensin-converting enzyme inhibitors and spironolactone
Authors: Sacharczuk Wioletta , Dankowski Rafał , Ożegowski Stefan , Rojna Maciej , Szyszka Andrzej
Published: April 2023

We aimed to compare therapies of sacubitril/valsartan + spironolactone (S/V + S) with angiotensin-converting enzyme inhibitors + spironolactone (ACEI + S) on the left-sided cardiac reverse remodeling (L-CRR). The second objective was to analyze the usefulness of GLS and LVEF in response to therapy.

Methods

78 patients (mean age 63.4 years, 20 females) with symptomatic heart failure with reduced ejection fraction were randomized to groups of equal numbers, i.e., 39 patients, and started on therapy of S/V + S or ACEI + S. Second evaluations were made after 6–8 weeks of therapy.

Results

GLS changed from −7.4% to −9.4% (18% improvement) in both arms equally. More than 50% of patients, initially with very severe systolic dysfunction (GLS > −8%), were reclassified to severe (GLS −8% to −12%). LVEF did not improve in any of the groups. The quality of life measured by MLHFQ and walking distance by 6-MWT increased. Positive correlations between GLS and 6MWT (r = 0.41, p = 0.02) and GLS and MHFLQ (r = 0.42, p = 0.03) were found. The S/V + S subgroup demonstrated improvements in LVEDV (Δ16.7 vs. 4.5 ml), E/e ratio (Δ 2.8 vs. 1.4), and LAVI (Δ 9.4 vs. 8.4 ml/m2) as compared to ACEI + S.

Conclusion

GLS, unlike LVEF, detects early changes in LV systolic function after 6–8 weeks of combined therapy, i.e., SV + S and ACE + S. GLS is more useful than LVEF in assessing early response to treatment. The effect of S/V + S and ACEI + S on LV systolic function was comparable, but the improvement in diastolic function as expressed by E/e’, LAVI, and LVEDV was more pronounced with S/V + S.
The incidence and risk factors of perioperative cardiac complications in noncardiac major surgery in high-altitude areas: A prospective trial in Tibet autonomous region, China
Authors: Zhu Qianmei , Duan Hanyu , Liu Zijia , Li Yi , Zhang Yuelun , Labaciren  , Shen Le , Huang Yuguang
Published: April 2023

Background

The risk of perioperative cardiac complications (PCCs) in patients living in high-altitude areas may increase with more adverse clinical outcomes due to the special geographical environment, which has not yet been studied. We aimed to determine the incidence and analyze risk factors for PCCs in adult patients undergoing major noncardiac surgery in the Tibet Autonomous Region.

Methods

This prospective cohort study enrolled resident patients from high-altitude areas receiving major noncardiac surgery in Tibet Autonomous Region People's Hospital in China. Perioperative clinical data were collected, and the patients were followed up until 30 days after surgery. The primary outcome was PCCs during the operation and within 30 days after the surgery. Logistic regression was used to build the prediction models for PCCs. A receiver operating characteristic (ROC) curve was used to evaluate the discrimination. A prognostic nomogram was constructed to generate a numerical probability of PCCs for patients undergoing noncardiac surgery in high-altitude areas.

Results

Among the 196 patients living in high-altitude areas involved in this study, 33 (16.8%) suffered PCCs perioperatively and within 30 days after surgery. Eight clinical factors were identified in the prediction model, including older age (P = 0.028), extremely high altitude above 4,000 m (P = 0.442), preoperative metabolic equivalent (MET) < 4 (P = 0.153), history of angina within 6 months (P = 0.037), history of great vascular disease (P = 0.073), increased preoperative high sensitivity C-reactive protein (hs-CRP) (P = 0.072), intraoperative hypoxemia (P = 0.025) and operation time >3 h (P = 0.043). The area under the curve (AUC) was 0.766 (95% confidence interval: 0.785–0.697). The score calculated from the prognostic nomogram predicted the risk of PCCs in high-altitude areas.

Conclusion

The incidence of PCCs in resident patients living in high-altitude areas who underwent noncardiac surgery was high, and the risk factors included older age, high altitude above 4,000 m, preoperative MET < 4, history of angina within 6 months, history of great vascular disease, increased preoperative hs-CRP, intraoperative hypoxemia, and operation time >3 h. The prognostic nomogram of this study could help to assess the PCCs for patients in high-attitude areas undergoing noncardiac surgery.

Clinical Trial Registration

ClinicalTrials.gov ID: NCT04819698.
Investigating interactive methods in remote chestfeeding support for lactation consulting professionals in Brazil
Authors: de Souza Jessica , Calsinski Cinthia , Chamberlain Kristina , Cibrian Franceli , Wang Edward Jay
Published: April 2023

Objective

Lactation consultants (LCs) positively impact chestfeeding rates by providing in-person support to struggling parents. In Brazil, LCs are a scarce resource and in high demand, risking chestfeeding rates across many communities nationwide. The transition to remote consultations during the COVID-19 pandemic made LCs face several challenges to solve chestfeeding problems due to limited technical resources for management, communication, and diagnosis. This study investigates the main technological issues LCs have in remote consultations and what technology features are helpful for chestfeeding problem-solving in remote settings.

Methods

This paper implements qualitative investigation through a contextual study (n=10) and a participatory session (n=5) to determine stakeholders’ preferences for technology features in solving chestfeeding problems.

Findings

The contextual study with LCs in Brazil characterized (1) the current appropriation of technologies that help during consultations, (2) technology limitations that affect LCs’ decision-making, (3) challenges and benefits of remote consultations, and (4) cases that are easy and difficult to solve remotely. The participatory session brings LCs’ perceptions on (1) components for an effective remote evaluation, (2) preferred elements by professionals when providing remote feedback to parents, and (3) feelings about using technology resources for remote consultations.

Conclusion

Findings suggest that LCs adapted their methodologies for remote consultations, and the perceived benefits of this modality show interest in continuing to provide remote care as long as more integrative and nurturing applications are offered to their clients. We learned that fully remote lactation care might not be the main objective for overall populations in Brazil, but as a hybrid mode of care that benefits parents by having both modalities of consultations available to them. Finally, remote support helps reduce financial, geographic, and cultural barriers in lactation care. However, future research must identify how generalized solutions for remote lactation care can be, especially for different cultures and regions.
Wavelet analysis and consensus algorithm-based fault-tolerant control for smart grids
Authors: Han Yunlong
Published: April 2023

In this paper, the voltage and frequency regulation problems are investigated for smart grids under the influence of faults. To solve those problem, a wavelet analysis and consensus algorithm-based fault-tolerant control scheme is proposed. Specifically, the wavelet analysis technique is introduced to determine whether there exist faults or not in the smart grids. Then, a distributed fault estimator is designed to estimate the attack signals. Based on this estimator state, a distributed fault-tolerant controller is designed to compensate for the faults. It is theoretically shown that the developed method can achieve the voltage regulation and frequency objectives. Finally, a smart grid with four distributed generations is constructed in MATLAB/Simulink for simulation to validate the effectiveness.
Citizens’ perception of the role of urban nature-based solutions and green infrastructures towards climate change in Italy
Authors: Sturiale Luisa , Scuderi Alessandro , Timpanaro Giuseppe
Published: April 2023

Climate change in recent years is shaping society’s habits and life in large cities, then it will be necessary to plan and design nature-based urban solutions to meet different interests and needs. To enable this approach between cities, urban green spaces and climate change, sustainable and resilient urban growth models are needed, planned with the contribution of citizens as priority stakeholders. Citizens perceive and attribute value to Green Infrastructures (GIs), albeit in relation to different socio-economic and environmental variables, the assessment of which has only recently been addressed in specific research. This research analysed citizens’ perceptions of GIs in combating the effects of the climate change. In particular, it revealed the degree of awareness of climate change, the value attributed to GIs and, finally, the willingness to pay to contribute to the maintenance of GIs in the city. The survey was carried out in the city of Catania (Italy), through the administration of questionnaires to a sample of residents (n = 500). The results show that the citizens involved perceive GIs as strategic elements of the quality of urban life, although they are not always aware of their positive impact on climate change. Interest in the co-management of GIs was higher in the case of crowdfunding. An integrated two-step methodological scheme was applied (divided in two phases, univariate and multivariate statistical analysis), which proved effective in analysing the different needs perceived by citizens. This approach could become a useful tool for planning GIs, especially in the current context in which cities are facing challenges related to climate change and changing societal needs. Understanding citizens’ views will be strategic in directing public investments towards GIs that can improve the quality of life in the urban ecosystem.
Chronic heat stress induces the expression of HSP genes in the retina of chickens (Gallus gallus)
Authors: Bastaki Nasmah K. , Albarjas Taybha A. , Almoosa Fatma A. , Al-Adsani Amani M.
Published: April 2023

Introduction: Chronic heat stress during summer is a major challenge imposed by global warming. Chickens are more sensitive to heat stress than mammals because they lack sweat glands. Thus, chickens are more susceptible to heat stress during summer than other seasons. Induction of heat shock protein (HSP) genes is one of the primary defense mechanisms against heat stress. Tissue-specific responses exhibited by different classes of HSPs upon exposure to heat stress have been reported previously in different tissues including the heart, kidney, intestine, blood, and muscle, but not in the retina. Therefore, this study aimed to investigate the expression levels of HSP27, HSP40, HSP60, HSP70, and HSP90 in the retina under chronic heat stress.

Methods: This study was conducted during the summers of 2020 and 2021 in Kuwait. Chickens (Gallus gallus) were divided into control and heat-treated groups and sacrificed at different developmental stages. Retinas were extracted and analyzed by using Real Time quantitative Polymerase Chain Reaction (RT-qPCR).

Results: Our results from the summer of 2021 were similar to that from the summer of 2020, regardless of whether GAPDH or RPL5 was used as a gene normalizer. All five HSP genes were upregulated in the retina of 21-day-old heat-treated chickens and stayed upregulated until 35 days of age, with the exception of HSP40, which was downregulated. The addition of two more developmental stages in the summer of 2021 showed that at 14 days, all HSP genes were upregulated in the retina of heat-treated chickens. In contrast, at 28 days, HSP27 and HSP40 were downregulated, whereas HSP60, HSP70, and HSP90 were upregulated. Furthermore, our results showed that under chronic heat stress, the highest upregulation of HSP genes was seen at the earliest developmental stages.

Discussion: To the best of our knowledge, this is the first study to report the expression levels of HSP27, HSP40, HSP60, HSP70, and HSP90 in the retina under chronic heat stress. Some of our results match the previously reported expression levels of some HSPs in other tissues under heat stress. These results suggest that HSP gene expression can be used as a biomarker for chronic heat stress in the retina.
Adjunctive therapeutic effects of micronutrient supplementation in inflammatory bowel disease
Authors: Wu Yanrui , Liu Chuan , Dong Weiguo
Published: April 2023

Growing evidence suggests that micronutrient status may have some impact on the course of inflammatory bowel disease (IBD). However, micronutrient deficiencies are easily overlooked during the treatment of IBD patients. There have been many studies on micronutrient supplementation, in which several clinical trials have been conducted targeting vitamin D and iron, but the current research is still preliminary for other vitamins and minerals. This review provides an overview of the adjunctive therapeutic effects of micronutrient supplementation in IBD, to summarize the available evidence, draw the attention of clinicians to micronutrient monitoring and supplementation in patients with IBD, and also provide some perspectives for future research directions.
Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC
Authors: Shi Jihang , Li Guangya , Liu Lulu , Yuan Xiandun , Wang Yafei , Gong Ming , Li Chonghui , Ge Xinlan , Lu Shichun
Published: April 2023

Objectives

The exhausted CD8+T (Tex) cells are a unique cell population of activated T cells that emerges in response to persistent viral infection or tumor antigens. Tex cells showed the characteristics of aging cells, including weakened self-renewal ability, effector function inhibition, sustained high expression of inhibitory receptors including PD-1, TIGIT, TIM-3, and LAG-3, and always accompanied by metabolic and epigenetic reprogramming. Tex cells are getting more and more attention in researching immune-related diseases and tumor immunotherapy. However, studies on Tex-related models for tumor prognosis are still lacking. We hope to establish a risk model based on Tex-related genes for HCC prognosis.

Methods

Tex-related GEO datasets from different pathologic factors (chronic HBV, chronic HCV, and telomere shortening) were analyzed respectively to acquire differentially expressed genes (DEGs) by the ‘limma’ package of R. Genes with at least one intersection were incorporated into Tex-related gene set. GO, KEGG, and GSEA enrichment analyses were produced. Hub genes and the PPI network were established and visualized by the STRING website and Cytoscape software. Transcription factors and targeting small molecules were predicted by the TRUST and CLUE websites. The Tex-related HCC prognostic model was built by Cox regression and verified based on different datasets. Tumor immune dysfunction and exclusion (TIDE) and SubMap algorithms tested immunotherapy sensitivity. Finally, qRT-PCR and Flow Cytometry was used to confirm the bioinformatic results.

Results

Hub genes such as AKT1, CDC6, TNF and their upstream transcription factor ILF3, Regulatory factor X-associated protein, STAT3, JUN, and RELA/NFKB1 were identified as potential motivators for Tex. Tex-related genes SLC16A11, CACYBP, HSF2, and ATG10 built the HCC prognostic model and helped with Immunotherapy sensitivity prediction.

Conclusion

Our study demonstrated that Tex-related genes might provide accurate prediction for HCC patients in clinical decision-making, prognostic assessment, and immunotherapy. In addition, targeting the hub genes or transcription factors may help to reverse T cell function and enhance the effect of tumor immunotherapy.
Overcoming tide-related challenges to successful regional and coastal ocean modeling
Authors: Byun Do-Seong , Choi Byoung-Ju , Hart Deirdre Erin
Published: April 2023

Rapidly growing ocean data availability is fueling the establishment of new regional and coastal ocean models and operating systems, while growing global climate disruption necessitates robust long-term simulations of regional and coastal ocean processes and hazard risks. This work explains, for the first time together in one place, solutions for overcoming three fundamental, tide-related technical challenges in regional and coastal ocean modeling: (1) automatic generation of tidal harmonic forcings from coarser tidal constant databases; (2) perpetual generation of interannual tidal predictions inside hydrodynamic models, such as in the Regional Ocean Modeling System (ROMS); and (3) producing ocean model harmonic constant forcing data using tide models. A modified tidal prediction code (set_tides.F) for continuous multi-decadal simulations in ROMS is also provided as a practical solution to the second challenge, while the complete suite of techniques explained herein allows researchers to avoid tide-related errors in establishing regional and coastal ocean models and operation systems, and to harmonically analyze their output data.
Feasibility of submerged floating tunnel with polygonal cross-sections — investigation from a viewpoint of submarine slide hazards
Authors: Fan Ning , Hu Yixuan , Wu Hao , Li Xiaobing , Jiang Jianxiong , Xie Jiacheng
Published: April 2023

Recently, submerged floating tunnels have generated a lot of interest due to their unique cross-water traffic benefits. However, the destructive threat of submarine slide hazards was not fully considered in the design scheme of submerged floating tunnels, in particular to the feasibility of applying various cross-section forms on land to submerged floating tunnels under that hazard influence. This study mainly investigates the load effect of submerged floating tunnels with polygonal cross-sections (comprising three types: square, hexagon, and octagon) under the impact of submarine slides, via a computational fluid dynamics (CFD) approach. Results show that the impact forces produced by submarine slides on submerged floating tunnels are significant (e.g., submarine slides with a velocity of 4 m/s may produce a force level near 1×105 N/m), where the horizontal impact force components should be given priority consideration based on the general working environment of submerged floating tunnels. Compared with typical circle tunnels, polygonal tunnels suffer higher impact forces, and the polygonal types with fewer edges show a greater impact force. Finally, a simplified force evaluation approach for the submerged floating tunnel with polygonal cross-sections is proposed for guiding the relevant engineering design.
Long COVID: Is there a kidney link?
Authors: Garrett Raymond E. , Palacio Carlos H. , Bar-Or David
Published: April 2023

Metabolic causes such as altered bioenergetics and amino acid metabolism may play a major role in Long COVID. Renal-metabolic regulation is an integral part of these pathways but has not been systematically or routinely investigated in Long COVID. Here we discuss the biochemistry of renal tubular injury as it may contribute to Long COVID symptoms. We propose three potential mechanisms that could be involved in Long COVID namely creatine phosphate metabolism, un-reclaimed glomerular filtrate and COVID specific proximal tubule cells (PTC) injury-a tryptophan paradigm. This approach is intended to allow for improved diagnostics and therapy for the long-haul sufferers.
Docetaxel-induced cognitive impairment in rats can be ameliorated by edaravone dexborneol: Evidence from the indicators of biological behavior and anisotropic fraction
Authors: Liu Ping , Liu Hai , Wei Lijun , Shi Xun , Wang Wei , Yan Shengxiang , Zhou Wenya , Zhang Jiangong , Han Suxia
Published: April 2023

Objective

This study aimed to investigate the effect of Edaravone Dexborneol (ED) on impaired learning and memory in docetaxel (DTX)-treated rats using cognitive behavior assessments and magnetic resonance diffusion tensor imaging (DTI).

Materials and methods

In total, 24 male Sprague–Dawley rats were divided into control, low-dose DTX (L-DTX) model, and high-dose DTX(H-DTX) model groups, with eight rats in each group, numbered 1–8. The rats were intraperitoneally injected with 1.5 mL of either normal saline (control group), or 3 mg/kg and 6 mg/kg DTX (L-DTX and H-DTX groups, respectively), once a week for 4 weeks. The learning and memory abilities of each group were tested using a water maze. At the end of the water maze test, rats 1–4 in each group were treated with ED (3 mg/kg, 1 mL), and rats 5–8 were injected with an equal volume of normal saline once a day for 2 weeks. The learning and memory abilities of each group were evaluated again using the water maze test, and the image differences in the hippocampus of each group were analyzed using DTI.

Results

(1) H-DTX group (32.33 ± 7.83) had the longest escape latency, followed by the L-DTX group (27.49 ± 7.32), and the Control group (24.52 ± 8.11) having the shortest, with the difference being statistically significant (p < 0.05). (2) Following ED treatment, compared to rats treated with normal saline, the escape latency of the L-DTX (12.00 ± 2.79 vs. 10.77 ± 3.97, p < 0.05), and the H-DTX (12.52 ± 3.69 vs. 9.11 ± 2.88, p < 0.05) rats were significantly shortened. The residence time in the target quadrant of H-DTX rats was significantly prolonged (40.49 ± 5.82 vs. 55.25 ± 6.78, p < 0.05). The CNS damage in the L-DTX rats was repaired to a certain extent during the interval between the two water maze tests (28.89 ± 7.92 vs. 12.00 ± 2.79, p < 0.05). (3) The fractional anisotropy (FA) value of DTI in the hippocampus of rats in the different groups showed variable trends. After treatment with ED, though the FA values of most areas in the hippocampus of rats in L-DTX and H-DTX groups were higher than before, they did not reach the normal level.

Conclusion

ED can ameliorate the cognitive dysfunctions caused by DTX in rats by improving the learning and memory impairment, which is reflected in the recovery of biological behavior and DTI indicators of the hippocampus.
UPS: Opportunities and challenges for gastric cancer treatment
Authors: Yang Hang , Ai Huihan , Zhang Jialin , Ma Jie , Liu Kangdong , Li Zhi
Published: April 2023

Gastric cancer remains the fourth most frequently diagnosed malignancy and the fifth leading cause of cancer-related mortality worldwide owning to the lack of efficient drugs and targets for therapy. Accumulating evidence indicates that UPS, which consists of E1, E2, and E3 enzymes and proteasome, plays an important role in the GC tumorigenesis. The imbalance of UPS impairs the protein homeostasis network during development of GC. Therefore, modulating these enzymes and proteasome may be a promising strategy for GC target therapy. Besides, PROTAC, a strategy using UPS to degrade the target protein, is an emerging tool for drug development. Thus far, more and more PROTAC drugs enter clinical trials for cancer therapy. Here, we will analyze the abnormal expression enzymes in UPS and summarize the E3 enzymes which can be developed in PROTAC so that it can contribute to the development of UPS modulator and PROTAC technology for GC therapy.
Combined systemic immune-inflammatory index and prognostic nutritional index predict outcomes in advanced non-small cell lung cancer patients receiving platinum-doublet chemotherapy
Authors: Fan Ruiyun , Chen Ying , Xu Guopeng , Pan Wen , Lv Yantian , Zhang Zhongwei
Published: April 2023

Background

Systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) could evaluate the therapeutic efficacy and prognosis in different tumors. However, no studies investigated the SII-PNI score to predict outcomes in non-small cell lung cancer (NSCLC) patients treated with platinum-doublet chemotherapy. The aim of this study was to investigate the SII-PNI score in predicting outcomes in non-small cell lung cancer (NSCLC) patients treated with platinum-doublet chemotherapy.

Materials and methods

Our study retrospectively analyzed clinical data from 124 patients with advanced NSCLC receiving platinum-doublet chemotherapy. The SII and PNI were calculated based on peripheral blood cell counts and serum albumin, and the optimal cut-off values were determined using receiver operating characteristic (ROC). All patients were divided into three groups according to the SII-PNI score. The association between the SII-PNI score and the clinicopathological characteristics of the patients was examined. The Kaplan-Meier and Cox regression models were used to assess progression-free survival (PFS)and overall survival (OS).

Results

There was no significant correlation between SII, PNI at baseline and chemotherapy response in patients with advanced NSCLC (p>0.05). However, after receiving 4 cycles of platinum-doublet chemotherapy, the SII of the SD group (p=0.0369) and PD group (p=0.0286) was significantly higher than that of the PR group. At the same time, the PNI of the SD group (p=0.0112) and the PD group (p=0.0007) was significantly lower than that of the PR group. The PFS of patients with SII-PNI scores of 0, 1, and 2 were 12.0, 7.0, and 5.0 months, and the OS of patients with SII-PNI scores of 0, 1, and 2 were 34.0, 17.0, and 10.5 months, respectively. There was statistical significance among the three groups (all p <0.001). Multivariate analyses showed that the chemotherapy response of progressive disease (PD) (HR, 3.508; 95% CI, 1.546-7.960; p=0.003) and SII-PNI score of 2 (HR, 4.732; 95% CI, 2.561-8.743; p < 0.001) were independently associated with a shorter OS. The uses of targeted drugs (HR, 0.543; 95% CI, 0.329-0.898; p=0.017) and immune checkpoint inhibitors (HR, 0.218; 95% CI, 0.081-0.584; p=0.002) were protective factors for OS in patients with NSCLC.

Conclusion

Compared with baseline parameters, the correlation between SII, PNI after 4 cycles of chemotherapy and the chemotherapy effect was more significant. The SII-PNI score after 4 cycles of chemotherapy is an effective prognostic biomarker for advanced NSCLC patients treated with platinum-doublet chemotherapy. Patients with a higher SII-PNI score had a worse prognosis.