bluuebunny/crossref_metadata_2025 huggingface dataset:
Frieden vermitteln auf neuem Terrain
Authors: Laufs Markus
Published: November 2023

This article presents the text of the instructions imparted by Cardinal Secretary of State Alderano Cybo to Luigi Bevilacqua, the apostolic nuncio and mediator at the multilateral peace congress of Nijmegen (1676–1679). It also offers a historical contextualization of the source, found in the Archivio Bevilacqua Ariosti in Bologna. The instructions reflect a change in Papal diplomacy, which remained active among the European powers even after the peace of Westphalia. By sending a nuncio into Protestant territory, Pope Innocent XI’s curia increasingly tended to integrate itself into the secularising diplomacy. During the peace negotiations, the Holy See tried to fulfil its ideal role as a padre comune, entailing strict impartiality between the conflicting Catholic parties. The orders regarding contacts with Protestant actors and interests are an example of the flexible dialogue of a normative text with the changing circumstances of 17th-century diplomatic practice. Although the wording reflects the intransigent tradition of the Holy See, the instructions show clear signs that the Protestant presence at the congress was handled pragmatically. On site, Bevilacqua even tried to go further and expand the recently established norm in favour of an effective interaction with Protestants, but ultimately failed.
Neue Forschungen zu Leonardo da Vinci als Ingenieur
Authors: Lohrmann Dietrich
Published: November 2023

Although the 500th anniversary of Leonardo’s death in 2019 produced a wealth of new publications, including a four-volume monograph by Carmen Bambach, annotated new editions and the first monograph on Leonardo as an engineer, the myriad problems posed by his scientific and technological legacy have by no means been resolved. Much remains to be done on the reconstruction of the numerous writings he announced or intended to write later. As regards major projects such as the drainage of the Pontine Marshes we should consider the extent to which Leonardo could truly have conceived the plans associated with him without the help of other experts. Leonardo’s claimed military ambitions when he left Florence for Milan in 1482 have been accepted in the newly published monographs, although a wealth of material from the following years indicates that he became familiar with military matters only much later. This is particularly true of the military qualifications Leonardo lists in his first letter to Ludovico Sforza. His famous letter dates to the year 1489 and not to Leonardo’s move from Florence to Milan in 1482.
On Ulam type of stability for stochastic integral equations with Volterra noise
Authors: Bishop Sheila A. , Iyase Samuel A.
Published: November 2023

This paper concerns the existence, uniqueness and stability of solutions of stochastic Volterra integral equations perturbed by some random processes. The obtained results extend, generalize and enrich the theory of stochastic Volterra integral equations in literature. Lastly, for illustration, we give an example that agrees with the theoretical analysis.
The crystal and molecular structure of 1-ferrocenyl-3,3-bis(methylthio)prop-2-en-1-one
Authors: Kumar Vedaant , May Kathleen L. , Lough Alan J. , Gossage Robert A.
Published: November 2023

The title compound 1-ferrocenyl-3,3-bis(methylthio)prop-2-en-1-one (1), a key intermediate in the synthesis of ferrocene-containing heterocycles, has been characterized by single-crystal X-ray diffraction. Compound 1 crystallizes in the monoclinic space group P21/c with 8 molecules in the unit cell. Unit cell parameters are 12.8159(10), 10.8121(9), and 20.8411(16) Å for a, b and c, respectively with β = 98.985(4)°. There are two distinct molecules in the asymmetric unit (A and B). Both molecules display a nearly eclipsed conformation with respect to the individual intramolecular cyclopentadienyl units in addition to close intramolecular contacts between the carbonyl O atom and one S atom of the bis-methylthiol functionality. Close intermolecular contacts involving A and B are noted with respect to S⋯H interactions between a thiol-S and the substituted Cp group in addition to C=O∙∙∙HC= interactions with the ene-moiety and a H atom located on one of the thiomethyl groups.
Paralog dispensability shapes homozygous deletion patterns in tumor genomes
Authors: De Kegel Barbara , Ryan Colm J
Published: November 2023

Genomic instability is a hallmark of cancer, resulting in tumor genomes having large numbers of genetic aberrations, including homozygous deletions of protein coding genes. That tumor cells remain viable in the presence of such gene loss suggests high robustness to genetic perturbation. In model organisms and cancer cell lines, paralogs have been shown to contribute substantially to genetic robustness—they are generally more dispensable for growth than singletons. Here, by analyzing copy number profiles of > 10,000 tumors, we test the hypothesis that the increased dispensability of paralogs shapes tumor genome evolution. We find that genes with paralogs are more likely to be homozygously deleted and that this cannot be explained by other factors known to influence copy number variation. Furthermore, features that influence paralog dispensability in cancer cell lines correlate with paralog deletion frequency in tumors. Finally, paralogs that are broadly essential in cancer cell lines are less frequently deleted in tumors than non‐essential paralogs. Overall, our results suggest that homozygous deletions of paralogs are more frequently observed in tumor genomes because paralogs are more dispensable.
Steroid profile in patients with breast cancer and in mice treated with mifepristone
Authors: Elía Andres , Saldain Leo , Lovisi Silvia , Martínez Vazquez Paula , Burruchaga Javier , Lamb Caroline A , Lüthy Isabel Alicia , Diez Federico , Homer Natalie Z M , Andrew Ruth , Rojas Paola , Lanari Claudia
Published: November 2023

Progesterone receptors (PRs) are biomarkers used as prognostic and predictive factors in breast cancer, but they are still not used as therapeutic targets. We have proposed that the ratio between PR isoforms A and B (PRA and PRB) predicts antiprogestin responsiveness. The MIPRA trial confirmed the benefit of 200 mg mifepristone, administered to patients with tumors with a high PRA/PRB ratio, but dose-ranging has not been conducted. The aim of this study was to establish the plasma mifepristone levels of patients from the MIPRA trial, along with the resultant steroid profiles, and compare these with those observed in mifepristone-treated mice using therapeutic schemes able to induce the regression of experimental mammary carcinomas with high PRA/PRB ratios: 6 mg pellets implanted subcutaneously, or daily doses of 12 mg/kg body weight. The plasma levels of mifepristone and other 19 plasma steroids were measured by liquid chromatography–tandem mass spectometry. In mifepristone-treated mice, plasma levels were lower than those registered in mifepristone-treated patients (i.e. day 7 after treatment initiation, pellet-treated mice: 8.4 ± 3.9 ng/mL; mifepristone-treated patients: 300.3 ± 31.7 ng/mL (mean ± s.d.; P < 0.001)). The increase in corticoid related steroids observed in patients was not observed in mifepristone-treated mice. The increase in progesterone levels was the most significant side effect detected in mifepristone-treated mice after 14 or 21 days of treatment, probably due to an ovarian compensatory effect not observed in postmenopausal patients. We conclude that in future clinical trials using mifepristone, the possibility of lowering the standard daily dose of 200 mg should be considered.
Teenager’s Resistance to Patriarchy in School: A Feminist Movement Representation on Moxie Film
Authors: Prasetya Adinda Angel Aulia Dewi , Oktafiyani Elve
Published: November 2023

PurposeThis research aimed to reveal the representation of patriarchy in school and teeanger's feminist movement on Moxie film. MethodThis qualitative research study employed a qualitative content analysis as the design of the research. The data from the film were selected, collected and analyzed using representation theory by Stuart Hall and feminism approach.Results/FindingsThe result showed that Moxie represented patriarchy in school by portraying female objectification, represive school regulation against female, patriarchy in student's reading material, male's achievement glorification, and supporting attitue towards patriarchal practices. Since the female students experienced various disadvantages, the film also represented their feminist movement through the publication of anonymous feminist magazine, the action of females speak up in the public, embracing lesbian identities, the action of visual protest symbolism and act of solidarity, the activism on social media, and the action of school vandalismConclusionThe female teenager in Rockport High School resisted patriarchy in school by representing different feminist movements based on their personal  experience and understanding of patriarchal practices and feminism
The Moral Concepts of Peta Kapanca Ceremony in Bima Community
Authors: Yono Yono , Sutisna Sutisna , Supriyanto Supriyanto , Amrin Amrin
Published: November 2023

PurposeThis article aimed to examine the moral concepts of peta kapanca ceremony as a tradition of the Bima people at every wedding ceremony.MethodThis study used an exploratory case study design which mainly depended so much on qualitative taken directly in the Bima Community of West Nusa Tenggara. The data collection applied observation, interviews and documentation and a literature study. In analyzing the data, it used classical hermeneutics and sociology. In addition, the study implemented data reduction, data presentation, and drawing conclusions stages of analysis.Results/findingsThe results showed that peta kapanca ceremony in the marriage of the Bima community had moral values, comprising how to worship Allah, how to behave and treat oneself and his family and how to behave and treat the society.ConclusionThe values contained in the peta kapanca are very relevant to the values in Islamic teachings. Thus, it is necessary for the Bima Regency government, community leaders, traditional leaders, and all levels of Bima society and the younger generation to increase awareness of the importance of preserving and caring for peta kapanca tradition and other local cultural traditions, so that they can grow and develop in line with the Islamic teachings and local wisdoms of Mbojo tribe in Bima.
Distribution and status of Posidonia oceanica meadows on the North-Western coast of Algeria
Authors: Bentaallah M. E. A. , Baghdadi D. , Cantasano N.
Published: November 2023

Posidonia oceanica is an endemic species of the Mediterranean Sea that in pristine coastal waters forms extensive meadows, which are, actually, exposed to natural and anthropogenic pressures, causing their regression throughout the basin. The aim of our study is to summarise and evaluate current knowledge about the characterisation of Posidonia oceanica along the Western Algerian coast, in order to provide new evidence about the distribution and health status this species. To realize our objectives, we combined extracted data from published articles, theses, results of project reports, in situ observations and laboratory analysis. The results show the presence of the meadows in fifteen coastal zones of Western Algeria, mainly located in shallow surface waters from 0.5 to 18 metres depth.The mean leaf length across all sites ranged from 153 to 667 mm. The mean number of leaves/shoot ranged between 4.7 ± 0.9 and 6.0 ± 0.5 leaves/shoot. Leaf length showed a highly significant difference between the cold and hot season. The data analysis shows that the leaf biometric values and the shoot densities of the P. oceanica are greater than those of Mediterranean samples although these measures tend to decrease deeply. The analyses carried out on structural features of P. oceanica show that the Western Algerian meadows are, globally, in good health status according to standardised scale. The available data on P. oceanica summarised in this article represent an important starting point to build effective plans for understanding levels of environmental threats and for supporting conservation strategies for these important ecosystems. Conversely, the limited information available on this seagrass along the Western Algerian costs only allows the description of some structural features, and permits us to draw overall conclusions on its general health status.
Thomas Kuhn's Science Paradigm
Authors: Fadilah Ai Aulia , Mulyana Mulyana , Ramadhan Ilham Naufal , Harianto Mahdia Nugraha
Published: November 2023

Thomas Kuhn's thinking in this case is used as an analytical knife to see the revolution in science and education in general. For Thomas Kuhn, the history of science is a starting point in studying fundamental issues in scientific epistemology because science is basically always marked by a strong scientific paradigm and revolution afterward. The purpose of this study is to find out the philosophical foundations of Thomas S. Kuhn's scientific paradigm. The method used is a qualitative approach by applying a descriptive-analytical method. The results of this study show that, according to Kuhn, a paradigm is a set of beliefs, values, methods, and practices that are widely accepted by the scientific community.
Clinical manifestations and expression of CD18 to guide the diagnosis of leukocyte adhesion deficiency type 1: Mexico experience
Authors: Fuentes-Lara Elma Isela , Arce-Estrada Gabriel Emmanuel , Bojalil-Cabildo Abner , Yamazaki-Nakashimada Marco Antonio , Espinosa-Padilla Sara Elva , Gamez-Gonzalez Luisa Berenise , Nideshda Ramirez-Uribe Rosa Mar�a , Saucedo-Ramirez Omar Josue , Berron-Ruiza Laura
Published: November 2023

Background: Leukocyte adhesion deficiency type 1 (LAD-1) is an inborn error of immunity characterized by a defect in leukocyte trafficking. Methods: Patients with clinical suspicion of LAD-1 were referred to our institution. Complete blood count and flow cytometric analysis, to identify the expression of CD18, CD11b, and the lymphocyte population phenotyping, were performed, and statistical analysis was completed. Results: We report clinical manifestations and immunological findings of six Mexican patients diagnosed with LAD-1. The diagnosis was based on typical clinical presentation, combined with laboratory demonstration of leukocytosis, and significant reduction or near absence of CD18 and its associated molecules CD11a, CD11b, and CD11c on leukocytes. We found atypical manifestations, not described in other countries, such as early-onset autoimmunity or infections caused by certain microorganisms. Conclusions: Patients with LAD-1 may present with atypical manifestations, making flow cytometry an indispensable tool to confirm the diagnosis. We present the first report of LAD-1 patients in a Latin American country.
Táticas de controle editorial à imprensa no Governo Bolsonaro: antigas e novas estratégias
Authors: Carvalho Guilherme
Published: November 2023

Propomos uma leitura atual de dados de organizações que indicam as estratégias adotadas pelo governo do presidente brasileiro Jair Messias Bolsonaro no que diz respeito à imprensa. Verificamos que as ações caracterizam-se pelas tentativas de estabelecer o controle editorial sobre jornalistas e jornais por meio de três recursos: o repasse cirúrgico de recursos públicos por meio de verbas publicitárias do governo, a judicialização dos conflitos com a imprensa e a descredibilização do trabalho jornalístico por meio de ataques públicos. O estudo aponta ainda uma condição histórica favorável ao exercício de práticas de controle e censura jornalística no Brasil, caracterizando particularmente a imprensa do país.
Effect of fragment size on growth and survival rate of Sarcophyton sp.
Authors: Dang Tran Tu Tram , Dao Thi Hong Ngoc , Nguyen Thi Nguyet Hue , Ho Son Lam , Dinh Truong An , Doan Van Than , Nguyen Truong Tan Tai , Do Hai Dang , Phan Kim Hoang , Tran Cong Thinh , Hua Thai An , Hoang Xuan Ben
Published: November 2023

The Sarcophyton sp. are very strong and dominant in many coral reef areas. Sarcophyton species are characterized by a distinct sterile stalk, a broad, flared, smooth, mushroom-shaped top, with a wide distribution and dominance in numerous coral reef areas extending from the Red Sea and eastern Africa to the western Pacific Ocean. They are cherished in marine aquariums for their diverse colors and adaptability. However, their excessive exploitation has significantly impacted resources and disrupted the balance of the soft coral biome that inhabits coral reefs. The objective of the current study was to assess the impact of fragment size (0.5 × 0.5; 1.0 × 1.0; 1.5 × 1.5; 2.0 × 2.0, and 2.5 × 2.5 cm) on survival rate, growth rate and time of attachment of coral Sarcophyton sp. in a closed seawater system. Each treatment involved three replicates with 20 cuttings per replicate, and the experimental period was 90 days. The experiment showed that the fragment size did not influence the growth rate of oral disc diameter, pedal disk diameter, and the time attachment of Sarcophyton sp. However, the size of the fragment affects the survival rate, height growth rate, and weight of Sarcophyton sp. colonies. These findings collectively suggest that the initial coral fragment size of 1.5 cm was suitable in laboratory conditions.
Reframing and Recontextualizing Maria Montessori’s 1915 California Visit
Authors: Parham Joel
Published: November 2023

Maria Montessori’s visit to California in 1915—her second visit to the United States—coincided with multiple events in the region: San Francisco’s Panama–Pacific International Exposition (PPIE), San Diego’s Panama–California Exposition (PCE), and the National Education Association of the United States (NEA) annual meeting in Oakland. Her visit also came at a time when the American Montessori movement was splintering, and the academic elite increasingly criticized her educational model. These circumstances made Montessori’s visit to California a potentially valuable opportunity to rekindle interest in Montessori education across the United States. Discussions of Montessori’s visit in 1915 have been framed around her training course and demonstration school at the PPIE. Based on information from primary sources (e.g., newspapers and archival materials), some of which have been overlooked, this article asserts that her visit to California had broader implications. While her eight months in California did have a positive impact on the growth of the Montessori movement, Montessori’s engagement with mainstream education had limited impact and it gave way to waning interest in Montessori education in the United States.
Computational Psychometrics: Near Future or Reality
Authors: Грачева Дарья , Тарасова Ксения
Published: November 2023

This book continues a series of books on the methodology of educational testing and assessment written by leading psychometricians and researchers in the field of educational assessment. Computational psychometrics is defined as the combination of computer science methods and psychometric measurement principles for analysing data obtained as a result of testing using technologically advanced test formats. The first part of the book discusses the changes that have occurred in teaching and educational assessment under the influence of digital technologies. The second part provides an overview of computational psychometric methods: from traditional psychometric models to machine learning technologies.

The material in the book can be useful to students and researchers in the field of psychometrics who are involved in the development, design and analysis of learning systems and measurements using complex test formats and data. The strength of the book is an electronic application containing the code of the R or Python programming environment for the methodological chapters.
DNA barcoding SOPs for the Darwin Tree of Life Project v1
Authors: Beasley Jordan
Published: November 2023

This collection of protocols describe the standard operating procedures for DNA barcoding in the Darwin Tree of Life project. The SOPs cover barcoding of macroalgae and marine protists, fungi and lichens at the Marine Biological Association, protists at the University of Oxford, plants and lichens at the Royal Botanic Gardens of Edinburgh and animals at the Natural History Museum of London.
CportucalensisOligoMediatedRecombineering v1
Authors: Tsypin Lev , K Newman Dianne , W Chen Allen , Saunders Scott
Published: November 2023

A protocol for introducing translational knockouts via oligo-mediated recombineering in C. portucalensis MBL.
CportucalensisElectrocompetentCells v1
Authors: Tsypin Lev , K Newman Dianne , W Chen Allen , Saunders Scott
Published: November 2023

Protocol to prepare electrocompetent Citrobacter portucalensis MBL cells.
Stereotaxic Injections v1
Authors: Meyerdirk Lindsay
Published: November 2023

This protocol details stereotaxic injections for any purpose, but in this case is primarily used for the injection of misfolded proteins.
Assessment of Changes in Trunk Parameters in Children with Scoliosis
Authors: Kamalova Shakhnoza Muzaffarovna  , Baymuradov Ravshan Rajabovich  , Temirova Nazokat Rustamovna  , Rasulova Mokhigul Matyokubovna
Published: November 2023

In this article, we examined the anthropometric data of the physical parameters of children with scoliosis under the age of 12. A total of 400 people of both sexes with asthenic, hypersthenic and normosthenic body types were under observation, divided into three age periods (newborns (the first 4 weeks after birth), the first period of childhood (3-7 years) and the second period of childhood (8-12 years). Physical indicators include body length and weight, gowdy circumference. Anthropometric studies of children were studied using a centimeter tape, the data obtained were statistically processed. In the statistical processing of the study data, the method of variational statistics was used with the calculation of the arithmetic mean (M), the error of the arithmetic mean (± m), the degree of reliable probability (P). The results of the study show that the curvature of the spinal column leads to the fact that the morphological parameters of different parts of the body become smaller compared to healthy children. In the first period of childhood, when these indicators were almost the same in both sexes, significant differences were found in the second period of childhood. Thus, it was found that during puberty, the lag of anthropometric indicators in children with scoliosis is aggravated in comparison with healthy children.
Socio-Economic Analysis of The Estuarine Fishermen Community Along The Nagavali and Vamsadhara Rivers in Andhra Pradesh, India
Authors: Sridhar Dumpala  , Vivek Chintada  , H Dhilleswara Rao  , Neredumilli Viswasanthi  , Srimanthula Srimadhuri  , Kakarlapudi Ramaneswari
Published: November 2023

This study conducted an analysis of the socio-economic conditions of fishermen in the estuarine regions of the Nagavali and Vamsadhara rivers in Andhra Pradesh, India. Over a period of two years from June 2012 to May 2014, data was collected to evaluate the livelihood and social status of the fishermen. The study is the first-ever documentation of this specific region. A wide range of data was collected from the study sites to analyze the socio-economic conditions of the fishermen. This included factors such as income generation, age distribution, housing, and literacy rates among the fishermen. It was found that fishing served as the primary source of income for the traditional fishermen, but they also engaged in various non-fishery related activities, which contributed significantly to their annual income. Based on the findings, it is recommended that the fishing profession be legalized and that settlements of traditional fishing communities be supported. These communities should be given priority in receiving necessary support from relevant stakeholders.
A Study on Attitude and Problems Faced by Teachers During Teaching in Corona Situation
Authors: Monu Sharma  , Rajani Chopra
Published: November 2023

The present study aimed to study the attitude and problems faced by teachers during teaching in corona situation. For collection the data survey method has been used. A total of 100 secondary level school teachers from Jaipur district have been selected as a sample of the study. Result showed that Majority of the teachers were agreeing with the statement that online teaching is the only way to teach students during this pandemic. The pandemic COVID-19 has shut the door of schools worldwide leaving no choice behind. Thus, each one fined online teaching easily accessible. It was found that online teaching is not an easy way to teach. There are so many technical (signal problem, availability of smart phone, electricity problem, knowledge of handling the apps as well as devices etc.) and psychological issues (non- interaction with all students, remedial teaching is not possible, speed of content delivery, lack of concentration etc.) faced by teachers and students as well.
Expression of dendrin, neurofilament and glial fibrillary acidic protein in the brain of the dogfish Scyliorhinus canicula L.
Authors: Restović Ivana , Vučemilo Marko , Obad Mia , Kević Nives , Kelam Nela , Racetin Anita , Bočina Ivana
Published: November 2023

Background and purpose: Dendrin is a brain and renal protein that is supposed to be involved in cytoskeletal modifications at the synapse and a part of the slit diaphragm and podocytes. Here, we aimed to investigate dendrin expression in dogfish brain since this newly discovered protein was never reported in fish. We compared the expression of dendrin to those of glial (GFAP) and neuronal (NF) proteins, which have already been described in the dogfish brain.
Materials and methods: Histological and immunofluorescent techniques were performed on tissue samples. The obtained data were statistically analyzed.
Results: Our results have shown that dendrin is expressed in all observed parts of the dogfish brain. In the forebrain, both observed parts (telencephalon and olfactory lobes) expressed dendrin. Regarding the percentage area of dendrin expression, it is expressed more in olfactory lobes than in the telencephalon. Compared with GFAP and NF expression, the expression of dendrin significantly differs in both parts of the forebrain. The highest dendrin expression was noticed in the midbrain. In dogfish midbrain, the difference in expression of dendrin in comparison to those of GFAP and NF was even more significant. The percentage area of dendrin expression in the hindbrain (cerebellum and medulla oblongata) was smaller than those in the forebrain and midbrain, contrary the percentage area of intermediate filaments GFAP and NF were significantly higher.
Conclusion: These results are the first report on dendrin expression in the dogfish brain opening the path for future studies on its role and function.
Croatian Microscopy Society 1983-2022
Authors: Poljuha Danijela
Published: November 2023

This paper provides a brief overview of the history of the Croatian Microscopy Society on the occasion of its 30th anniversary as an independent society and the 40th anniversary of its foundation. The overview chronologically details the period of the Society's work as the Section for Electron Microscopy of the Croatian Natural Science Society (1983-1992), followed by its independent activity first as the Croatian Society for Electron Microscopy (1992-2006) and finally as the Croatian Microscopy Society (2006-present). The review concludes with recent trends and policies in the Society's development. The review is an extended excerpt from the opening speech held by the Chair of the 4th Croatian Microscopy Congress and a member of the Society’s board, on the occasion of the Society's anniversary, May 18th 2022.
SEM and TEM investigations of materials at the Centre for Electron Microscopy and Microanalysis (CEMM)
Authors: Čeh Miran , Hreščak Jitka , Drev Sandra
Published: November 2023

Modern state-of-the-art electron microscopy (EM) techniques are among the most versatile and useful analytical methods for nondestructive morphological, structural, and chemical characterization of materials. Both, scanning electron microscopy techniques (SEM) and transmission electron microscopy techniques (TEM), in essence complementary analytical methods, are capable of providing insight into the surface morphology, structure and chemical composition of materials from micrometer range to sub-atomic range. The importance of electron microscopy techniques in materials science have been readily recognized by the researchers of the Jozef Stefan Institute very early after its foundation in 1949 which resulted in the purchase of the first transmission electron microscopy Carl Zeiss EM-8 already in 1954. During the following years many researchers and institute directors have put a lot of effort into building and developing EM research infrastructure at the institute with accompanying expertise.
Cerebral autoregulation and autonomic nervous system: A narrative review
Authors: Saini Prashant Kumar , Thomas Sheffy , Parakulangara Midhula
Published: November 2023

Cerebral autoregulation (CA) is the process through which the brain maintains a sufficient cerebral blood flow (CBF) despite varying cerebral perfusion pressure (CPP). When systemic BP varies, the cerebral vasculature's inherent CA protection mechanism works to maintain CBF stability. The autonomic nervous system (ANS), among other physiological pathways, may impact CA disturbances. Cholinergic and adrenergic nerve fibers innervate the cerebral vascular system. Several reasons, such as the complexity of the ANS and cerebrovascular interactions, measurement flaws, differences in methods used to evaluate the ANS concerning CBF, and experimental strategies that can or cannot shed light on the sympathetic control of CBF, the role of the ANS in regulating CBF is hotly debated. To comprehend the mechanisms underlying the reported crosstalk between the controls of the heart and the cerebrovascular system, one needs to define more precisely the frequency bands to compute spectral CA markers and develop models more in line with physiology to describe the behavior of CA; it may be helpful to study the involvement of the autonomic nervous system (ANS) on CA. The review investigates how the ANS affects CA, which could significantly impact diagnosing and treating pathological diseases.
A review on plants possesses anti tubercular activity
Authors: Prajapati Anil Kumar , Patil Pratiksha , Joshi Sneha
Published: November 2023

Tuberculosis is an infectious disease condition that mainly affects the lungs, and the responsible bacteria is . Over 4,000 people each day die from this disease, which also claims 1.2–1.5 million lives annually and has infected 1.7–2 billion individuals globally.

The literature review was conducted by studying the research papers and review articles concentrating on the traditional plants having “Antituberculosis activity or anti-mycobacterial activity”, in electronic databases like PubMed, Science Direct, Scopus, and Google Scholar.

The available synthetic therapy for tuberculosis treatment includes first-line treatment of five drugs namely “Isoniazid, Rifampicin, Ethambutol, Pyrazinamide, and Streptomycin. The synthetic drugs used in the treatment of tuberculosis result in hepatotoxicity and also cause resistance against bacteria, resulting in MDR TB and XDR TB. Plant-derived drugs have potent activity against tuberculosis bacteria also they give hepatoprotective activity, unlike the synthetic drugs with no resistance against the bacteria.

Medicinal plant products are good alternatives to allopathic medicine with fewer side effects and with less chances of resistance. Because polyherbal formulation act by different mechanisms to inhibit the growth of bacteria. More research is required to explore the plant-based treatment of TB.
Migration crisis under J. Biden administration: new trends
Authors: Kochegurov Dmitry
Published: November 2023

The article deals with the problem of the migration crisis in USA: consequences of liberal migration policy of J. Biden and actions of his administration to combat the crisis. The topic of hearings in Congress on the issue of security on the southwest border of USA is being raised. Particular attention is paid to the development of the situation after the end of the restrictions of Title 42. Based on the analysis, the author comes to the conclusion that the admission of illegal migrants to the country led to an unprecedented migration crisis, the Biden administration is not able to offer a comprehensive plan for overcoming the crisis, and therefore the initiative is gradually moving to Congress.
Atlantic solidarity of Germany: between the "restrictive policy" and the export of weapons to conflict zones
Authors: Khrishkevich Tatiana
Published: November 2023

The article analyzes the approaches of the German government to limiting the export of weapons to conflict zones. The article correlates the supply of military weapons of Germany and the United States. The increase in the volume of supplies to Ukraine confirms the commitment of the German government to Atlantic solidarity with the United States and NATO. Political principles, export legislation, the National Security Strategy of Germany, the draft Law on Arms Export Control, which offer restrictive approaches to the supply of lethal weapons to conflict zones, are not being implemented in practice. They are declarative documents.  The article analyzes the public and political discussion that has developed around the restrictions that should be introduced into the law on arms export control.
Liderazgo y desempeño organizacional en pequeñas y medianas empresas en Chile
Authors: Araya Pizarro Sebastián
Published: November 2023

El estudio analizó la relación entre los estilos de liderazgo y el desempeño organizacional en pequeñas y medianas empresas (pymes) de una economía emergente. Para ello, se encuestaron a 119 administradores de empresas del sector comercial de Chile (región de Coquimbo). Los datos se examinaron con la técnica de ecuaciones estructurales y el análisis de regresión lineal múltiple. Los hallazgos revelaron que solo el estilo de liderazgo transformacional resulta significativo para el desempeño organizacional. Particularmente, se halló que existe una relación positiva entre el liderazgo transformacional y los resultados financieros, estratégicos y de satisfacción. También se develó que todas las dimensiones de desempeño se relacionan directa y significativamente entre sí. Se concluye que el ejercicio de un liderazgo que promueve soluciones a los problemas de manera creativa y participativa, sobre la base del reconocimiento de las necesidades personales, capacidades y aspiraciones de los colaboradores, incide favorablemente en el desempeño organizacional.
Relative expression levels of growth hormone gene and growth rate in Indian major carp species
Authors: Sherzada Shahid , Nauman Sharif Muhammad , Ali Qurban , Khan Saeed Akram , Shah Tawaf Ali , El-Tabakh Mohamed A. M. , Aziz Tariq , Nabi Ghulam , Alharbi Metab , Albekairi Thamer H. , Alasmari Abdullah F
Published: November 2023

The phenomenon of growth is a leading factor for aquaculture success. The uneven growth of major Indian carps (Labeo rohita, Catla catla, and Cirrhinus mrigala) is a serious issue in fish culture from an economic point of view. The growth hormone (GH) gene is crucial for selection in commercially cultivated fish species for better growth and production. Indian major carp (L. rohita, C. catla, and C. mrigala) are commonly cultured in Pakistan. The GH expression was examined using qPCR to understand growth in fish species better. Muscle tissue samples (n=480) from 160 individuals of the same age were collected from three species (L. rohita, C. catla, and C. mrigala). Individuals were divided into two groups (high-weight and low-weight groups), cultured under normal conditions. The housekeeping gene β-actin validated GH expression in fast and slow-growing fishes from the same species. Results showed that GH expression varies across species and fish specimens that overweight their counterpart feature have higher GH expression. A selection for overweight fish in the aquaculture breeding systems is preferable as those fish could inherit their genomics to the future cohort, enhancing production, and commercial profit for farmers. Comprehensive research about different growth genes and the environmental aspects that influence fish growth is mandatory. No work has been reported regarding the growth gene analysis of fish from Pakistan. This report was Pakistan’s first and baseline study regarding growth analysis of main culturable fish species at the molecular level.
Complete Left Bundle Branch Block in Acute Coronary Syndrome with ST Segment Elevation: Epidemiological Features
Authors: ZOUZOU Hanane
Published: November 2023

Background: Complete left bundle branch in acute coronary syndrome with ST segment elevation is not common, but known as a sign of poor prognosis.
Several international studies had reported its incidence and related mortality, but its epidemiological data is lacking in Algeria.
Aims: The main objective of our study is the determination of the frequency of complete left bundle branch block in acute coronary syndrome with ST segment elevation, the secondary objective was the analysis of its predictive factors and related mortality.
Methods and materials:  In this prospective study, conducted in the cardiology department of Hussein Dey hospital (Algiers-Algeria), 467 patients with acute coronary syndrome with elevated ST segment (87 women and 380 men) were enrolled between 28 February 2014 and 16 July 2015. The average age is 60 ± 13 years; at admission, a Holter recorder was attached for continuous ECG monitoring during 48 hours.
Kruskal’s ANNOVA or H tests were used for comparison of quantitative variables, χ2 test or Fisher’s exact test, were used for qualitative variables, all tests were performed with 1st species risk of 5%.
Results:  The frequency of complete left bundle brunch block is 1.7 % (8 patients), CI 95%: [0.5%-2.9%], multivariate analysis identified the two independent predictors: diabetes type 1, and Angiotensin Receptor-Blockers as current treatment.
Despite the risk of mortality expressed by Hazard Ration (HR) is 4.7, but remains not significant: CI95%: [0.62-36], p = 0.134; however, the risk of ventricular fibrillation occurrence is high, with relative risk (RR) at 7.17, CI 95 %: [2.70-19.03], p = 0.007.
Conclusion: Complete left bundle brunch block is not common in acute coronary syndrome with elevated ST segment, its predictive factors according to our study are: Diabetes type 1 and Angiotensin Receptor-Blockers as current treatment.
The high-risk mortality in the left bundle brunch block group isn’t significant; however the risk of ventricular fibrillation occurrence is high.
Perspectivas sobre a inquisitorialidade no processo penal brasileiro: heranças do tecnicismo-fascista
Authors: Silveira Felipe Lazzari da
Published: November 2023

O presente artigo tem como escopo problematizar as raízes do autoritarismo no processo penal brasileiro, especificamente o legado do tecnicista-fascista e sua contribuição para a manutenção da estrutura processual vigente e da racionalidade que viabiliza o arbítrio no campo. Sua elaboração foi procedida mediante pesquisa histórica, através de revisão de bibliografia e de documentos pertinentes ao tema, sendo que os resultados da investigação estão estruturados em quatro tópicos, nos quais são analisados a construção dos paradigmas inquisitoriais; a forma como eles foram reaproveitados pela tradição jurídico-penal liberal e pelo positivismo criminológico e se consubstanciaram no tecnicismo-jurídico; o desenvolvimento da processualística fascista; e os pormenores da introdução da orientação tecnicista-fascista  no processo penal brasileiro e seus reflexos no atual contexto.
A inclusão escolar de crianças e adolescentes migrantes e na condição de refúgio, não-falantes do português: a barreira da linguagem e as demandas no processo de ensino-aprendizagem
Authors: Viana Custódio André , Cabral Johana
Published: November 2023

Este artigo tem por objetivo identificar as principais demandas, no processo de ensino-aprendizagem, pela barreira da linguagem, da inclusão escolar, no Brasil, de crianças e adolescentes migrantes e na condição de refugiados, não-falantes do português. A partir da contextualização do direito à educação no Brasil, apresentou-se a presença e a inclusão de crianças e adolescentes migrantes no âmbito escolar, para então, na terceira parte da pesquisa, identificar as principais demandas, no processo de ensino-aprendizagem. A metodologia utilizada foi o método de abordagem dedutivo, o método de procedimento monográfico e as técnicas de pesquisa bibliográfica e documental.
Direito de (trans)cender: o direito humano à identidade de gênero no âmbito do sistema interamericano de direitos humanos
Authors: Vilas Boas Taques João Daniel , Fachin Melina
Published: November 2023

A presente investigação, desenvolvida por meio do método lógico dedutivo, tem como objetivo analisar os limites e possibilidades de construção de um direito humano à identidade de gênero no âmbito do Sistema Interamericano de Direitos Humanos. Buscou-se demonstrar, em um primeiro momento, a situação precariedade imposta às pessoas trans na região da América Latina, privadas de direitos básicos. Após, objetivou-se analisar como os direitos da população LGBTQIA+ foram construídos no âmbito do sistema regional. Ao final, almejou-se demonstrar como é possível construir, com base nos direitos previstos na Convenção Americana de Direitos Humanos, um direito humano à identidade de gênero.
Direitos constitucionais, princípios formais e equilíbrio
Authors: Gavião Filho Anizio Pires
Published: November 2023

Esta pesquisa tem como objetivo abordar a função dos princípios formais na ponderação de princípios. A questão central a ser examinada é se os princípios formais podem ser ponderados em relação aos princípios materiais. Uma ponderação direta com os princípios materiais ou uma ponderação mista leva à subconstitucionalização. A resposta está no modelo epistêmico da ponderação. Os princípios formais exigem respeito às decisões do legislador tomadas no espaço de discricionariedade epistêmica. O resultado é que os princípios formais servem para determinar os limites da intensidade do controle da jurisdição sobre as decisões do legislador competente e democraticamente legitimado. Pesquisa desenvolvida sob o método bibliográfico comparativo.
Uma abordagem crítica à noção de verdade jurídico-penal a partir da análise da linguagem
Authors: Busato Paulo César , Dall'Agnol de Souza Eduardo Emanoel
Published: November 2023

Este trabalho analisa criticamente o uso da expressão verdade em matéria jurídico-criminal. A análise segue três etapas. Na primeira, apresenta-se a formação de uma pretensão de verdade em matéria penal. Na segunda, faz-se a crítica à verdade a partir de seus problemas intrínsecos e de seus usos em matéria penal. Na terceira etapa, mostra-se que a pretensão de verdade está diretamente ligada a uma lógica autoritária, incompatível com um Estado de direito democrático. Ao final, propõe-se o abandono da pretensão de verdade em matéria penal e sua substituição pela pretensão de justiça.
Global e tecnologia: reflexões sobre a ciência do direito e o modelo de jurista na era digital
Authors: Julios-Campuzano Alfonso de
Published: November 2023

A nossa era é marcada pela globalização, pela revolução tecnológica e pelo desenvolvimento vertiginoso das novas tecnologias de informação e comunicação. Nesta era digital e global, os parâmetros que estabeleceram o quadro das relações humanas em sentido lato e os modelos interpretativos da realidade foram drasticamente alterados. Assim, na segunda modernidade, estamos testemunhandoo surgimento de uma nova concepção de direito. O novo paradigma jurídico do Direito Global é delineado por três movimentos, deslocamentos ou traduções de elementos definidores do direito da primeira modernidade e da concepção do sistema jurídico em que se baseou, que determinam novas características que contribuem para reconfigurar a concepção do direito e do sistema jurídico e propor uma reconsideração cosmopolita da Ciência do Direito e do papel do jurista nesta mudança de época.
Os cursos de direito como espaços de produção e difusão do conhecimento
Authors: Francischetto Gilsilene Passon Picoretti
Published: November 2023

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Interwencje walutowe jako element polityki banków centralnych
Authors: Pszczółka Ireneusz
Published: November 2023

This paper discusses the issue of central banks intervene in foreign exchange markets in order to achieve a variety of overall economic targets. The main immediate objectives of this intervention are: to influence the level of the exchange rate; to dampen exchange rate volatility or supply liquidity to foreign exchange markets; and to influence the amount of foreign reserves. This paper focuses also on different channels of influence. The main stress was put on the analyses of the effectiveness of some examples of foreign exchange intervention conducted by some central banks, both form emerging and developed economies.
Pałac późnobizantyński i jego ceremoniał
Authors: Macrides Ruth
Published: November 2023

The main aim of this article is to draw researchers’ and readers’ attention to neglected and underestimated Byzantine source known as Pseudo-Kodinos. The fourteenth-century text which is one of two surviving ceremonial books from the Byzantine empire, next to “Book of Ceremonies”, includes the combination of hierarchical lists of court officials with protocols of ceremonies; a detailed description of the clothing used at court; an account of the functions of the court title holders, a description of the ceremonies of the year which take place both inside the palace and outside and much more. Based on that, the author of the article is trying to bring developments in ceremonial which occurred since tenth century and discussed the space in which ceremonial was performed. Without any archeological research the author depicts the Blachernai palace, its setup and structure, its buildings and chambers, and compares it with those of Great Palace. In the article can be also found description of most important ceremonies which were held in the Blachernai Palace such as Christmas or Epiphany. Finally the author answers questions why Michael VIII Palaeologus, establishing new dynasty in Constantinople, chose as a place of his residence the Blachernai Palace.
Władysław Strzemiński – seria kolaży „Moim przyjaciołom Żydom”. Doświadczenia wojny, żal i smutek
Authors: Jedlińska Eleonora
Published: November 2023

Celem niniejszego opracowania jest przedstawienie i pogłębiona
interpretacja unikalnego w dorobku Władysława Strzemińskiego
(1893–1952) i w ogóle historii sztuki, zespołu prac zatytułowanego
Moim przyjaciołom Żydom (1945/1946?). Moim zadaniem było wykazanie
jak na tle koncepcji awangardy artystycznych XX w., których
Strzemiński był głównym ideologiem i twórcą, kształtowały się
losy tego artysty, jego przyjaźni, fascynacji artystycznych, zaangażowania
w życie społeczne oraz jak – w obliczu wydarzeń II wojny
światowej i Zagłady – idealistyczne, niespełnione marzenia uległy
ostatecznemu, jak uważał, zniszczeniu. Podstawowym zadaniem
było dokonanie niejako nowej interpretacji cyklu poprzez skupienie
uwagi na kontekście historycznym, politycznym i społecznym,
które uwarunkowały powstanie cyklu dziesięciu kolaży.