bluuebunny/crossref_metadata_2025 huggingface dataset:
Classification of methods for fixing brake checks in the shoes of the brake lever transmission of freight cars
Authors:   Irkutsk State Transport University (ISTU), Treskin S. V.
Published: August 2024

The article is devoted to ensuring reliable fixation of brake checks in the shoes of the brake lever transmission of freight cars. It is shown that mainly the loss of brake checks occurs when unloading freight cars with car dumpers. The reason for the loss of brake checks is the imperfection of the way the brake pad is connected to the shoe. The scientific works, which present the designs of the brake check, brake shoe and pads, are analyzed, the advantages and disadvantages of such designs are considered. The author of the article proposes a classification of methods to prevent the loss of brake checks, improving the connection of the shoe to the shoe by upgrading the basic design of the brake check, as well as upgrading the brake check using a spring lock.
Classifi cation of measuring instruments and test facilities on railway transport (a study of diagnostic devices for brakes tests and trials)
Authors:   Ural State University of Railway Transport, Antropova Tatyana A.
Published: August 2024

The paper considers measuring instruments and test facilities used on railway transport. The classification of various diagnostic devices used for acceptance of wagon brakes and testing of trains is analyzed. Conclusions are drawn based on the results of the analysis.
O LUGAR DO INTELECTUAL OUVINTE NO MOVIMENTO SURDO BRASILEIRO: REFLEXÕES A PARTIR DE UMA EXPERIÊNCIA SINGULAR
Authors: Regina Maria de Souza  , Gallo Danilo Altenfelder Colussi
Published: August 2024

O presente trabalho colocará em questão a possibilidade de ouvintes e surdos participarem de um movimento político que demanda, ao pesquisador ouvinte, uma posição ética radical: a de participar das ações necessárias para fazer virem à tona os anseios políticos e históricos de distintas comunidades surdas afiliadas à Federação Nacional de Educação de Surdos (FENEIS - Brasil). Para o desenvolvimento das reflexões que serão realizadas, os autores se inspirarão em Michel Foucault, Derrida e Noam Chomsky para discutir a presença do intelectual em movimentos sociais que militam por conquistas de direitos de um grupo ao qual ele próprio não pertence. No trato específico das demandas dos movimentos surdos serão trazidas as contribuições realizadas por pesquisadores surdos em um livro organizado pelas pesquisadoras e militantes surdas Gladis Perlin e Mariane Stumpf (2012).
TERMINOGRAFIA DAS CIÊNCIAS BIOLÓGICAS EM LÍNGUA BRASILEIRA DE SINAIS (LIBRAS)NA PRODUÇÃO DIDÁTICA
Authors: Fontes Gisele de Souza , Witchs Pedro Henrique
Published: August 2024

O artigo discute sobre a terminografia das Ciências Biológicas em língua brasileira de sinais (Libras) a partir da produção didática. Para tanto, com base na Linguística Aplicada Indisciplinar e nos estudos do léxico de línguas de sinais, analisa 10 materiais compreendidos entre 2005 e 2021, identificados como livros, glossários, dicionários, manuais e guias didáticosque contêm termos em Libras relacionados com a Biologia. Identifica-se que o material apresenta diferenças estruturais e que nenhuma das produções inclui definições ou explicações conceituais em Libras embora apresentem termos nessa língua. Além disso, observa-se que a tradução em Libras de termos da Biologia, mais recentemente, resulta de trocas linguísticas na Educação Básica, de modo que algumas produções são motivadas no contexto escolar da educação de surdos. A partir dessa discussão, espera-se contribuir com o avanço das compreensões sobre a produção de materiais didáticos comprometidos com a aprendizagem envolvendo línguas de sinais nas últimas décadas.
Spontaneous Intracranial Hemorrhage in a 34-Year-Old Male Patient Related to Hypertensive Emergency
Authors: Nurmalasari Mifta , Widodo Djoko
Published: August 2024

Highlight:

Unhealthy lifestyles are believed to be cause of hypertension at a young age.
Untreated hypertension increases cardiovascular disease morbidity and mortality.
The incidence of intracranial hemorrhage associated with hypertension is approximately 60%. It commonly occurs in the deep brain structure, which is considered to have a poor clinical outcome.

 
ABSTRACT
Introduction: The incidence of hypertension is currently moving toward younger ages. It’s thought that an unhealthy lifestyle serves as a trigger. Hypertension can increase morbidity and mortality related to cardiovascular disease, even at a young age. This case report is intended to report the incidence of spontaneous intracranial hemorrhage in a 34-year-old male patient during a hypertensive emergency. Case: A 34-year-old male patient was rushed to the emergency unit at midnight due to a sudden decrease in consciousness. Headaches and seizures occurred before admission. The patient denied having any history of head trauma. The patient’s habits included excessive caffeine consumption, frequent late-night sleeping, and extensive smoking. At the time of admission, the patient’s vital signs indicated a poor clinical condition: GCS E1V1M1, BP 212/118 mm/Hg, deep irregular rapid breathing, sometimes followed by periodic apnea, RR 28 breath/minute, HR 111 beat/minute, SpO2 50%, T 36.8°C, which gradually developed hyperthermia. Both eyes had constricted and fixed pupils; the light reflexes were negative. A neurological examination revealed the body’s left lateralization. The head CT scan without contrast indicated hemorrhage in the right intracerebral, midbrain, pons, intraventricular, and subarachnoid areas, with estimated total volume of about 31 ml. Conservative treatment was chosen due to the bleeding location in the deep brain structure of GCS 3, which was considered to have a poor outcome. Conclusion: Hypertension in the younger age group is commonly associated with unhealthy lifestyles, which increase morbidity and mortality related to cardiovascular disease.
Chemotherapy-Induced Peripheral Neuropathy: Pathophysiology, Diagnosis, and Treatment
Authors: Justitia Ica , Dewi Putri Krishna Kumara , Fauzi Yanuar Rahmat , Hunaifi Ilsa
Published: August 2024

Highlight:

Chemotherapy induces neurotoxicity through DNA crosslink, impaired calcium homeostasis, mitochondrial damage, increased reactive oxygen species, pro-inflammatory cascade, axon degeneration, and programmed cell death.
CIPN has a primary impact on the sensory neuron.
CIPN is diagnosed based on the patient's history, chemotherapy history, and neurologic examination. Some pharmacological and non-pharmacological treatments are hypothesized to reduce CIPN symptoms, but only duloxetine is recommended.

 
ABSTRACT
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common and severe neurological side effect of many commonly used chemotherapy agents. It affects more than 60% of cancer patients. Approximately 30%–40% of patients have persistent symptoms five months or longer after stopping treatment. Even years after completing chemotherapy, some patients still experience CIPN symptoms. CIPN increases the annual cost of healthcare, leads to detrimental dose reduction and even cessation of treatment, and severely affects cancer survivors’ quality of life. Chemotherapy induces neurotoxicity through a variety of mechanisms that lead to neuronal cell damage or cell death. This mechanism of neurotoxicity varies depending on the specific agent. CIPN is characterized predominantly by sensory axonal peripheral neuropathy. Motor and autonomic symptoms may appear, but less frequently. To diagnose CIPN, a thorough patient's history and neurological examination are required. The current approach to CIPN management focuses on managing the symptoms of neuropathic pain and reducing or stopping the chemotherapy agent when CIPN manifests. There is no proven or advised prophylaxis therapy for CIPN. The point of this review was to talk about how some commonly used chemotherapy agents (such as platinum-based compounds, taxanes, vinca alkaloids, bortezomib, and thalidomide) cause CIPN, how to diagnose it, and the newest treatments that are available.
Profile of Meningioma Patients at Dr. Soetomo General Academic Hospital
Authors: Valeryna Natasha , Ardiansyah Djohan , Susanto Joni , Utomo Sri Andreani
Published: August 2024

Highlight:

Meningioma, the most common primary brain tumor, is typically found in women aged 40-49 years old.
Meningiomas can show distinctive characteristics on clinical, radiological, and histopathological examinations.
There were significant differences in histopathological grading between male and female patients, as well as between homogenous and heterogenous contrast enhancement.

 
ABSTRACT
Introduction: Meningioma is an intracranial extracranial tumor that arises from arachnoid cells. It is reported to be the most common primary brain tumor (39%). Meningioma is diagnosed based on clinical and radiological findings, but a definitive diagnosis requires histopathology examination. However, the clinical, radiological, and histopathological profile of meningioma is rarely studied in Indonesia. Objective: This study aimed to identify the clinical, radiological, and histopathological profile of meningioma patients at Dr. Soetomo General Academic Hospital Surabaya from 2017 to 2021. Methods: This was a retrospective observational study with a cross-sectional design using secondary data collected from electronic medical records at Dr. Soetomo General Academic Hospital Surabaya in 2017-2021. Results: A total of 256 patients were included in this study. The majority of the patients in this study were female (83.98%), aged 40-49 years old (43.36%), and mostly had the clinical symptom of headache (35.94%). Meningiomas were mostly WHO grade I (85.16%), with a transitional subtype (44.92). Based on the Kruskal-Wallis test, there were differences in histopathological grading between male and female patients (p = 0.000), as well as between homogenous and heterogenous tumor enhancement (p = 0.027). However, there were no differences in histopathological grading between the dural tail findings (p = 0.181) and hyperostosis findings (p = 0.135). Conclusion: Meningioma was found to be more common in females than in males, with the peak occurring in 40-49 years old. The most prevalent clinical symptom was headache, and convexity was the most common location for these tumors, most of which were larger than 3 cm. The majority of meningiomas were WHO grade I with transitional subtype.
The Profile of Navy Military Students with Superficial Fungal Foot Infections : A Descriptive Study
Authors: Medisika Dhea , Prakoeswa Cita Rosita Sigit , Sawitri Sawitri , Hidayati Afif Nurul , Utomo Budi , Rahmadewi  , Agung Jeffrey , Ervianty Evy
Published: August 2024

Background: Superficial fungal foot infection is an infectious disease caused by dermatophyte, Candida spp., and mold. Risk factors are thought due to poor personal hygiene, frequent used of closed shoes, and high physical activity. Purpose: Investigate the profile and the risk factors of superficial fungal foot infections in military students. Methods: This is a cross-sectional study. Inclusion criteria for this study were navy military students with lesions on their feet. Result: This study involved 194 students as the populations with 97 students as the sample of the study. The average age were 17-25 years old, and male students being the major. Erythema and scale were found in the plantar and interdigital pedis. Students with good personal hygiene were 81 students among 97 students (83,5%). Wearing closed shoes for > 8 hours were found in 72 students among 97 students (74.2%). Most of the students exhibit a high physical activity with an average score of 26,880 MET minutes/week. Positive KOH 20% and cultures were found in 30 students (30.9%). Negative KOH 20% and positive culture were found in 27 students (27.8%). Positive KOH 20% and negative cultures were found in 9 students (9.3%). Negative KOH 20% and negative fungal culture results were found in 31 students (31,9%). Mold was the predominant fungal type. Conclusion: The students had good personal hygiene. The average wears closed shoes for >8 hours. Mold was the predominant fungal type in this study.
The Relationship Between Diet and Body Mass Index with Events of Acne Vulgaris among Medical Students
Authors: Bunga Yeheskiel Holoaino , Manuputty Amanda Gracia , Asmin Elpira , Lestaluhu Santi Aprilian , Djuhastidar Tando Yudhie
Published: August 2024

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit characterized by clinical features such as comedones, papules, pustules, and nodules that affect social and psychological functions. Foods containing carbohydrates with a high glycemic index can trigger acne vulgaris. Consumption of fatty foods, chocolate, milk, nuts, and cheese can stimulate the recurrence of acne vulgaris. Objective: This study aims to determine the relationship between dietary habits and body mass index (BMI) and the incidence of acne vulgaris among students of the Faculty of Medicine of Pattimura University. Methods: This research is an observational analytic study with a cross-sectional design. Samples were selected using a proportional stratified random sampling technique with a simple random sampling approach, totaling 89 respondents. Respondents were required to fill out the SQ-FFQ questionnaire and undergo height and weight measurements. Result: Out of 89 respondents, 81% frequently (≥2×/day) consumed carbohydrates 82% often (1×/day) consumed proteins and 71% often (1×/day) consumed reduced-fat. Regarding the quantity of intake, 55% of respondents consumed high carbohydrates per day, 69% consumed high proteins per day, and 24% consumed high fat intake per day. The prevalence of acne vulgaris was 66%p-value <0.05. Conclusion: There is a significant relationship between dietary habits based on carbohydrate, protein, and fat intake and the incidence of acne vulgaris. However, there is no significant relationship between BMI and the incidence of acne vulgaris among medical students at Pattimura University.
Nevus Unius Lateris (NUL) in a Theree-Year-Old Child Treated by Tretinoin 0.025%, Desoxymethasone 0.25%, and Urea 20% Cream
Authors: Stephanie Aurelia , Vibriyanti Karna NLP Ratih , Karmila IGAA Dwi , Laksmi Hermina , Stella Aurelia
Published: August 2024

Background: Linear verrucous epidermal nevus is the most frequent variant of the epidermal nevus classification. Linear verrucous epidermal nevus is characterized by the proliferation of epithelium arranged in a configuration that follows Blaschko's line. Nevus unius lateris (NUL) is a variant of the verrucous epidermal nevus, which has a unilateral distribution of lesions. Lesions are usually found at birth or in the first year of life as brown to grey verrucous papules or papillomatous plaques. The management of NUL is challenging as the results are varied and there is a high risk of recurrence. Purpose: to report a case of NUL and its management, especially in children. Case: A 3-year-old girl presented with brownish spots and multiple small lumps on the left buttock that have extended to the left leg since she was 9-days-old. On dermatologic examination, there were numerous hyperpigmented verrucous papules and plaques along the Blaschko line over the affected area. In this case, the diagnosis of NUL, is based on clinical symptoms and dermoscopy examination showed multiple large brown oval or round structures with hyperpigmented brown border. The patient was treated with combination topical therapy of tretinoin 0.025%, corticosteroid desoxymethasone 0.25%, and urea 20% cream, and the lesion improved within four weeks. Discussion: Epidermal nevus is often cosmetically disturbing. The treatment is still challenging and various, including surgical and non-surgical, but none is ideal and could potentially recur over months or years. dst.
Analysis of Personal Hygiene and Characteristics of Living Environment in Elementary Student with Pediculosis Capitis
Authors: Petri Alya , Murlina Nelli , Nurfadly  , Hervina
Published: August 2024

Background: Pediculosis capitis is one of the parasitic infections that can cause pruritus and allergic reactions. The prevalence of Pediculosis capitis is relatively high and can occur both in developed and developing countries regardless of socioeconomic status. The occurrence of Pediculosis capitis can be caused by poor personal hygiene factors and living environmental conditions, which can also increase the incidence of this ectoparasitic infection. Purpose: To analyze the correlation between personal hygiene and characteristics of the living environment, and the incidence of Pediculosis capitis. Methods: This study is quantitative research with a correlational analysis method and a cross-sectional study approach. Result: The examination of the correlation between poor personal hygiene and the incidence rate of Pediculosis capitis showed a result of 0.000 (p<0.05). Similarly, the examination of the correlation between the characteristics of the living environment and the incidence rate of Pediculosis capitis also showed a figure of 0.000 (p<0.05), indicating that there is a correlation between personal hygiene, and the characteristics of the living environment, and the incidence rate of Pediculosis capitis. Conclusion: There is a significant correlation between personal hygiene, and the characteristics of the living environment, and the incidence of Pediculosis capitis.
Assessing the Potential Diagnostic Value of Indonesian Local Allergen Skin Prick Testing (SPT) for Cow’s Milk Allergy among Atopic Dermatitis Patients
Authors: Anggraeni Sylvia , Damayanti  , Umborowati Menul Ayu , Prakoeswa Cita Rosita Sigit
Published: August 2024

Background: Atopic dermatitis (AD) is a multifactorial chronic, frequently recurrent, inflammatory skin condition. The development of IgE-mediated food allergies and food sensitivity are both associated with atopic dermatitis. Cow’s milk allergy (CMA) caused the most common hypersensitivity reaction during childhood; however,  the prevalence in adults is around 0.5%. Patients with AD use the Skin Prick Test (SPT) to evaluate the specific sensitization process. Purpose: This study aimed to assess cow's milk allergy among adult AD patients using local allergen extract SPT, standard SPT, and specific IgE (sIgE), as well as evaluating the conformity and relevance of the test results. Methods: Using consecutive sampling technique, the study was conducted twice on 45 adult AD patients with a one-week interval between administrations. Result: Local cow's milk SPT showed 4 positive results, and standard SPT showed 5. No sIgE test was positive. Local SPT was negative for 86.67% of individuals without a history of suspected cow's milk allergies. Standard SPT results were positive for 2.22% of individuals with a history of suspected cow's milk allergies and negative for 86.67% of those without. The relevance between local and standard SPT was shown to be substantial (k = 0.384, p = 0.000). Conclusion: The result of the local cow’s milk SPT and the patient’s history had good conformity, and the relevance with standard SPT was significant in diagnosing cow’s milk allergy among AD patients.
Empowering Healthcare Professionals: an Effort to Enhance Sexually Transmitted Disease Knowledge
Authors: Prakoeswa Flora Ramona Sigit , Sari Winda Atika , Hidayat Saiful , Romadhon Yusuf Alam
Published: August 2024

Background: Sexually transmitted diseases (STDs) present a significant challenge in the public health field. Health professionals are at the forefront of controlling the transmission and management of this disease; hence, efforts to update knowledge regarding STDs are very important for this group. Purpose: This study aims to explain the effect of integrated counseling on increase STD knowledge in an effort to prevent the occurrence of sexually transmitted diseases. Methods: We carried out health education activities containing material related to aetiology, modes of transmission, risk factors, risk groups, and therapy for sexually transmitted diseases at one hospital in Surakarta. The Sexually Transmitted Disease Knowledge Questionnaire (STD-KQ) was used to assess participants' knowledge regarding STDs, which was distributed before and after giving the material. The difference in STD-KQ scores before and after the counselling session was analysed using the Wilcoxon Test. Result: Prior to the counselling session, 22 (32.83%) participants had poor knowledge, 41 (61.19%) had moderate knowledge, and only 4 (5.97%) possessed a good understanding of STDs. Following the counselling session, there was a noteworthy improvement in knowledge levels, with 47 (70.14%) participants now classified as having good knowledge. Additionally, 18 (26.86%) participants maintained a moderate level of knowledge, while 2 (2.98%) retained poor knowledge. The analysis showed that the difference was statistically significant (P value < 0.001).
Operational Dynamic Load Testing for Repair Recommendations Case Study of Access Road to Vehicle Weight in Motion
Authors: Khoeri Heri , Dini Sofiana  , Panji Nugroho  , Rauzan Fikri Muthohari
Published: August 2024

The indication of inaccuracies in vehicle weight measurement using Weight in Motion (WIM) technology on mining roads has been identified due to the non-fulfillment of the design criteria required by the WIM manufacturer. This study aims to identify the gap between the actual pavement conditions and the design criteria and to design improvements to eliminate this gap. The method employed involves dynamic load testing, followed by processing the test data with operational modal analysis (OMA) to obtain dynamic parameters that will serve as a reference for calculating the pavement capacity. From OMA, a natural structural frequency of 26.342 Hz was obtained, while the theoretical calculation based on the design criteria was 29.481 Hz. This frequency decrease indicates structural damage of 10.65% and a capacity reduction of 26.8% from the design criteria. This finding is reinforced by a critical damping ratio of 5.25%, which is higher than the damping for intact concrete, ranging between 2%-5%. This indicates energy dissipation through concrete cracks. It is recommended to inject the cracks in the existing pavement with a cement base and perform a 130 mm overlay with mortar grout (fc’= 50 MPa) with one layer of M12 wire mesh. The connection with the old pavement will use concrete bonding and D13-600/600 chemical anchors. With this improvement, the structural capacity will become 104% of the design criteria.
The Significance of Holistic Spirituality in Sunan Kalijaga’s Kidung Rumekso Ing Wengi
Authors: Lestari Sri
Published: August 2024

This research aims to explain the holistic spirituality of Kidung Rumekso ing Wengi by Sunan Kalijaga. In addition to being used in various situations to pray, the song needs to be studied for the sake of cultural preservation, historical understanding, literary wealth, identity, and local pride. This study is qualitative. The data used in this study consisted of documents and interviews. Data was collected through interviews and document analysis. The data validation technique uses triangulation of theory and method, while the data analysis technique uses Miles and Hubermann's interactive model and Roland Barthes' markers. Based on interviews with sources and literature studies, Kidung Rumekso ing Wengi is a counter-acceptance mantra taught by Sunan Kalijaga to his followers. Until now, there are still people who have developed hymns and the practice of hymns as a medium of prayer by paying attention to aspects of tolerance. There are various values, such as the ethics of vigilance, returning to Allah, the ethics of prayer, and self-control.
Stylistic and Rhetoric Elements on Memes in Education Context: A Critical Discourse Analysis
Authors: Guntar Muhammad , Husein Rahmad , Pulungan Anni Holila
Published: August 2024

In this digital age, the presence of internet memes becomes a common way to share information online. People may use different stylistic and rhetoric elements to communicate their ideas and convey a particular meaning. This paper aimed to analyze stylistic and rhetoric elements employed in the selected memes in education context by using Van Dijk Critical Discourse Analysis. The data were forty memes related to education which were collected from four Instagram groups, namely itb.receh, school_life memoriess, 9gag.com, and memeindonesia.real. This research utilized descriptive qualitative method. The result showed that in stylistic, the most dominant dictions used were slang and denotative. The high frequency of using slang is done as a strategy to express a sense of familiarity to audiences and to show portrait of daily basis situation in students’ lives, while the use of denotative dictions conveys clear understanding and avoid misinterpretation toward these memes. Furthermore, in rhetoric elements, no metaphor is found in the selected memes while graphics is mostly used in the memes to highlight important parts. It was delivered through the production of words in bigger size, bold, different colour, different type of fonts, words which are crossed out, and the use of emoticon. Graphic provides a visual representation for audiences and these highlighted words help them comprehend messages and values which the writer is trying to deliver.
The Models of Primary Particles
Authors: Fu Lan
Published: August 2024

If we assume that: a. The four fundamental forces of nature are independent waves without rest masses, and their speeds are constant in a vacuum, just like light. b. Light or electromagnetic waves and gravity are comparable in structures. Weak and strong interactions are similar in structures. c. Light and weak interaction have the same speed cL with spin number +1 or –1. d. Gravity and strong interaction have the same speed cG without spin. e. The primary particles, namely electrons, electron neutrinos, and dark neutrinos in this paper, are made by the above four waves. We can find and describe some fundamental characteristics of the primary particles (e.g., their sizes, energies, and interactions) and introduce new attractive results from them (e.g., the source of the Pauli exclusion principle, the solution to the Einstein-Podolsky-Rosen paradox, and cG slightly faster than cL).
Quantum Cosmology Part I: The Integration of Special Relativity and Quantum Mechanics
Authors: Kahan Dennis
Published: August 2024

The inability to delineate a unified physical ontology that accounts simultaneously for the laws of special relativity and the results of quantum experiments has been a defining problem in physics for more than 100 years. This analysis addresses the problem by positing a novel mixed ontology composed of a “discrete” 4D spacetime and a physical, ultra-high dimensional (3 x N) “Planck Space.” Together, Planck Space and the three spatial dimensions of 4D spacetime form a tightly integrated ((3 x N) + 3) hyperspace (the “Dual Ontology”).Critically, the Dual Ontology’s structure replaces 1) the continuous, differentiable manifold of 4D spacetime with a discrete, background-independent 4D spacetime that is intrinsically curved and 2) mathematical spaces with a physical (3 x N) Planck Space. Moreover, the Dual Ontology is structurally and dynamically predicated on the one-to-one mapping and identity between the discrete spatial units that simultaneously form 4D spacetime and Planck Space. The one-to-one mapping and identity of the discrete spatial units support an integrated quantum dynamics based upon the dynamic evolution of single and N-body quantum states in 4D spacetime in full compliance with the laws of special relativity and the instantaneous collapse of all quantum states in an ontic Planck Space, where special and general relativity and more generally, 4D spacetime’s laws of physics, do not apply.
Digital Genome and Self-Regulating Distributed Software Applications with Associative Memory and Event-Driven History
Authors: Mikkilineni Rao , Kelly W. Patrick , Crawley Gideon
Published: August 2024

Biological systems have a unique ability inherited through their genome. It allows them to build, operate, and manage a society of cells with complex organizational structures where autonomous components execute specific tasks and collaborate in groups to fulfill systemic goals with shared knowledge. The system receives information from various senses, makes sense of what is being observed, and acts using its experience, while the observations are still in progress. We use the General Theory of Information (GTI) to implement a digital genome, specifying the operational processes that design, deploy, operate, and manage a cloud-agnostic distributed application that is independent of IaaS and PaaS infrastructure, which provides the resources required to execute the software components. The digital genome specifies the functional and non-functional requirements that define the goals and best-practice policies to evolve the system using associative memory and event-driven interaction history to maintain stability and safety while achieving the system’s objectives. We demonstrate a structural machine, cognizing oracles, and knowledge structures derived from GTI used for designing, deploying, operating, and managing a distributed video streaming application with autopoietic self-regulation that maintains structural stability and communication among distributed components with shared knowledge while maintaining expected behaviors dictated by functional requirements.
A Conjecture on the Possible Another Supermassive Black Hole in the Bar of Our Milky Way
Authors: Zhu Yin
Published: August 2024

In the bar of our Milky Way, there should be another supermassive black hole B which is with the mass almost 10−2~10−5 the Sgr A* and with a distance almost 10,000 lightyears from the Sgr A*. The bar is formed by the stars that are orbiting around the two black holes Sgr A* and B. And, in the bar, a lots of stars orbit around B while another lots of stars around Sgr A*. The two orbits form the peanut shape with “x-shaped structure” in the bar, while the boxy core is formed with all of the three orbits. And, the orbits of the stars out of the bar could be repulsed to a distant place by the black hole B to form the galactic spiral arms.
Nano-Enhanced Polymer Composite Materials: A Review of Current Advancements and Challenges
Authors: Musa Abdulrahman Adeiza , Bello Abdulhakeem , Sani Mohammed Adam , Onwualu Azikiwe Peter , Anye Vitalis C. , Bello Kamilu Adeyemi , Obianyo Ifeyinwa Ijeoma
Published: August 2024

Nanomaterials have shown significant promise for enhancing the performance of composite materials and increasing their functionality for various industrial applications. This review explores the unique properties of nanomaterials, particularly carbon-based nanomaterials, and provides key findings in utilizing them to enhance composite performance. It highlights specific nano-based composite materials and their significant potential in advancing the field of nanocomposites. Challenges associated with nanocomposite production and utilization are also discussed, along with possible solutions to address them. Finally, the study provides recommendations for continued research and innovation in nanocomposites to fully unlock the benefits of these advanced materials for broader future applications.
Entropy Considerations in Stochastic Electrodynamics
Authors: Cole Daniel
Published: August 2024

The use of entropy concepts in the field of stochastic electrodynamics is briefly reviewed here. Entropy calculations to date that have been fully carried out are discussed in two main situations: first, where electric dipole oscillators interact with zero-point, or zero-point plus Planckian, or Rayleigh-Jeans radiation, and second where only these radiation fields exist within a cavity. The emphasis here will be on the first more difficult situation where both charged particles and radiation fields are present and interacting. Unlike the usual exposition on entropy in clasical statistical mechanics involving probabilistic notions of phase space occupation, the calculations to date for both particles and fields or for fields alone, follow the caloric entropy method where the notions of heat flow, adiabatic surfaces, and isothermal conditions, are utilized. Probability notions certainly still enter into the calculations, as the fields and charged particles interact stochastically together, following Maxwellian electrodynamics. Examples of phase-space calculations for harmonic oscillators and classical hydrogen atoms are carried out, emphasizing how much farther caloric entropy calculations have been successfully utilized.
Energy‐Efficient Clustering in Wireless Sensor Networks Using Grey Wolf Optimization and Enhanced CSMA/CA
Authors: Kaddi Mohammed , Omari Mohammed , Salameh Khouloud , Alnoman Ali , Awad Mohammed
Published: August 2024

Survivability is a critical concern in WSNs, heavily influenced by energy efficiency. Addressing severe energy constraints in WSNs requires solutions that meet application goals while prolonging network life. This paper presents an energy optimization approach (EOAMRCL) for WSNs, integrating the Grey Wolf Optimization (GWO) for enhanced performance. EOAMRCL aims to enhance energy efficiency by selecting the optimal duty-cycle schedule, transmission power, and routing paths. The proposed approach employs a centralized strategy using a hierarchical network architecture. During the cluster formation phase, an objective function, augmented with GWO, determines the ideal cluster heads (CHs). The routing protocol then selects routes with minimal energy consumption for data transmission to CHs, using transmission power as a metric. In the transmission phase, the MAC layer forms a duty-cycle schedule based on cross-layer routing information, enabling nodes to switch between active and sleep modes according to their network allocation vectors (NAV). This process is further optimized by an enhanced CSMA/CA mechanism, which incorporates sleep/activate modes and pairing nodes to alternate between active and sleep states. This integration reduces collisions, improves channel assessment accuracy, and lowers energy consumption, thereby enhancing overall network performance. EOAMRCL was evaluated in a MATLAB environment, demonstrating superior performance compared to EEUC, DWEHC, and CGA-GWO protocols, particularly in terms of network lifetime and energy consumption. This highlights the effectiveness of integrating GWO and the updated CSMA/CA mechanism in achieving optimal energy efficiency and network performance.
Comparative Analysis of OSEM Parameters for Cardiac SPECT Imaging Across Multiple Camera Brands: A Monte Carlo Study
Authors: Abojayab Ghassan , Guvenis Albert
Published: August 2024

Background and Objective: To examine the effect of ordered subset expectation maximization (OSEM) parameters on the quantitative image quality of cardiac SPECT images in two different frequently used SPECT cameras and determine the optimal settings for producing images of best diagnostic quality. Another objective was to assess if different cameras produced a significant change in optimal parameters and levels of detectability. Methods: The optimization of OSEM iterative reconstruction algorithm was carried out by comparing image quality metrics, namely, contrast-to-noise ratio (CNR) and defect contrast across 12 OSEM subset-iteration combinations to find the best choice for cardiac perfusion SPECT images. Eight frames were reconstructed using the SIMIND Monte Carlo Simulation package. An activity of 370 MBq (10mCi) and projection acquisition interval of 20 seconds per projection were used. Attenuation (AC) and scatter corrections (SC) were performed in this study for all images. Results: The 16-2 subset-iteration combination yielded the highest CNR and defect contrast values for both cameras. The difference between CNR values for two cameras was found to be around 5% only. Conclusions: Monte Carlo simulations can be useful to investigate how quantitative image quality behaves with respect to reconstruction parameters and correction algorithms in a controlled environment. The found optimum is similar to values reported in previous findings. In this study, the use of different camera brands did not affect the optimum. The quantitative detectability measures were also very similar.
Efficacy of a Virtual Reality Rehabilitation Protocol based on Art Therapy in Subacute Phase of Stroke
Authors: Tieri Gaetano , Iosa Marco , Fortini Antonio , Aghilarre Federica , Gentili Federico , Rubeca Cristiano , Mastropietro Tommaso , Antonucci Gabriella , De Giorgi Roberto
Published: August 2024

Art therapy has a long history of applications in cognitive and motor rehabilitation. More recently, a growing body of scientific literature has highlighted the potential of virtual reality in neurorehabilitation, though it has focused more on the technology itself than on the principles adopted in digital scenarios. This study is a randomized controlled trial conducted on 40 patients with stroke, comparing a protocol of art therapy administered in virtual reality, which exploits the so-called Michelangelo effect, to conventional therapy. After 12 sessions, patients in the virtual art therapy group showed a significantly greater improvement in independence in activities of daily living, as assessed by the Barthel Index (interaction of time and group: p<0.01). Significant differences were also found in terms of upper limb muscle strength (Manual Muscle Test, p<0.01) and reduction in spasticity (Ashworth scale, p<0.01) in favor of the experimental group. In the virtual art therapy group, the effectiveness of the intervention was significantly correlated with patient participation (Pittsburgh Rehabilitation Participation Scale: R=0.45), patient satisfaction (R=0.50), and the perceived utility of the intervention by the therapist (R=0.47). These findings support the efficacy of virtual art therapy leveraging the Michelangelo effect. Further studies should also focus on cognitive domains that could benefit from this type of approach.
Artifacts of Glory and Pain:Evolving Cultural Narratives on Confederate Symbolism and Commemoration in a New Era of Social Justice, a Personal Perspective
Authors: Jameson John H.
Published: August 2024

The American Civil War has been commemorated with a great variety of monuments, memorials, and markers. These monuments were erected for a variety of reasons, beginning with memorialization of the fallen and later to honor aging veterans, commemoration of significant anniversaries associated with the conflict, memorialization sites of conflict, and celebration of the actions of military leaders. Sources reveal that during both the Jim Crow and Civil Rights eras, many were erected as part of an organized propaganda campaign to terrorize African American communities and distort the past by promoting a ‘Lost Cause’ narrative. Through subsequent decades, to this day, complex and emotional narratives have surrounded interpretive legacies of the Civil War. Instruments of commemoration, through both physical and digital intervention approaches, can be provocative and instructive, as the country deals with a slavery legacy and the commemorated objects and spaces surrounding Confederate inheritances. Today, all of these potential factors and outcomes, with internationally relevance, are surrounded by swirls of social and political contention and controversy, including the remembering/forgetting dichotomies of cultural heritage. The modern dilemma turns on the question: In today’s new era of social justice, are these monuments primarily symbols of oppression, or can we see them, in select cases, alternatively as sites of conscience and reflection encompassing more inclusive conversations about commemoration? What we save or destroy and assign as the ultimate public value of these monuments rests with how we answer this question. In this essay, drawing from the testimony of scholars and artists, I address the conceptual landscape of approaches to the presentation and evolving participatory narratives of Confederate monuments that range from absolute expungement and removal to more restrained ideas such as in situ re-contextualization, removal to museums, and preservation-in-place.
Field Ion Microscopy of Tungsten Nano-Tips Coated with Thin Layer of the Epoxy Resin
Authors: Sobola Dinara , Alsoud Ammar , Knápek Alexandr , Mousa Marwan , Schubert Richard , Kočková Pavla , Škarvada Pavel
Published: August 2024

This paper reports results of analysis of field ion emission mechanism from tungsten-epoxy composite emitters that are compared to tungsten nano-field emitters. In this context, the mechanism of emission from this type of emitters is described based on a theory of induced conductive channels. The tungsten emitters were prepared using the electrochemical polishing technique and coated with a layer of the epoxy resin. Field ion microscope (FIM) analyses are reported including the study of the emission-ion density distributions from both the uncoated and coated emitters. Two forms of emission patterns have been observed in the ion emission microscopy technique describing the differences in the emission mechanism of both types of emitters. The observed results show: (a) the expected crystalline surface atomic distribution images of the field ion microscopy in the case of uncoated tungsten tips, and (b) randomly distributed emission spots that describe the locations of the induced conductive channels inside the resin coating layer.
Investigation of the Effect of Thymoquinone on Egfr/FOXP3 Signaling Pathway in OVCAR3 Human Ovarian Adenocarcinoma Cells
Authors: Özdemir İlhan , Şanlı Aktaş Ayfer , Tuncer Mehmet Cudi
Published: August 2024

Aim: In our study, the chemotherapeutic drug doxorubicin (Dox) and the natural anticancer property thymoquinone (TQ) were applied to OVCAR3 human ovarian adenocarcinoma cells and human skin keratinocyte cell line HaCat cells, and their cytotoxic effects were investigated through the EGFR/FOXP3 signaling pathway.
Materials and Methods: In our study, different doses of thymoquinone and doxorubicin were applied to the cells for 24, 48 and 72 hours and the cytotoxicity level was determined by the MTT method. With Western blot and qRT-PCR analysis, metastasis markers Epidermal growth factor receptor (EGFR) and forkhead box p3 (FOXP3) and apoptosis marker apoptosis inbibitory 5 (API5) genes and their expression levels were examined. Colony counting was performed after DAPI staining and its effect on cell proliferation was determined. An in vitro wound model for metastasis was created and cell migration was evaluated morphologically. All results were analyzed statistically.
Results: By the cell viavility test, it was found that cytotoxicity was at the highest level in the TQ and Dox applied group, metastasis was prevented especially in the TQ and Dox combined treatment group, and by qRT-PCR analysis, the activity in the EGFR and FOXP3 pathway decreased the most with TQ and the amount of protein decreased with TQ and Dox.
Conclusion: As a result of the study, it was seen that the highest cytotoxic effect and the highest apoptosis induction occurred with TQ treatment. Additionally, it was determined that a significant decrease in EGFR and FOXP3 levels occurred in TQ and Dox applications.
Remotely Powered 2-Wire Cooperative Sensors for Bioimpedance Imaging Wearables
Authors: Chételat Olivier , Rapin Michaël , Bonnal Benjamin , Fivaz André , Sporrer Benjamin , Rosenthal James , Wacker Josias
Published: August 2024

Bioimpedance imaging aims to generate a 3D map of the resistivity and permittivity of biologi-cal tissue from multiple impedance channels measured with electrodes applied to the skin. When the electrodes are distributed around the body (for example, by delineating a cross-section of the chest or a limb), bioimpedance imaging is called electrical impedance tomography (EIT) and results in 2D functional images. Conventional EIT systems rely on individually cabling each electrode to master electronics in a star configuration. This approach works well for rack-mounted equipment; however, the bulkiness of the cabling is unsuitable for a wearable system. Previously presented cooperative sensors solve this cabling problem using active (dry) elec-trodes connected via a two-wire parallel bus. The bus can be implemented with two unshielded wires or even two conductive textile layers, thus replacing the cumbersome wiring of the con-ventional star arrangement. Prior research demonstrated cooperative sensors for measuring bi-oimpedances, successfully realizing a measurement reference signal, sensor synchronization, and data transfer though still relying on individual batteries to power the sensors. Subsequent research using cooperative sensors for biopotential measurements proposed a method to re-move batteries from the sensors and have the central unit supply power over the two-wire bus. Building off our previous research, this paper presents this method applied to the measurements of bioimpedances. Two different approaches are discussed, one using discrete, commercially available components, and the other with an application specific integrated circuit (ASIC). Initial experimental results reveal that both approaches are feasible, but the ASIC approach offers ad-vantages for medical safety, as well as lower power consumption and smaller size.
Tailoring Deep Learning for Real-Time Brain-Computer Interfaces: From Offline Models to Calibration-Free Online Decoding
Authors: Wimpff Martin , Zerfowski Jan , Yang Bin
Published: August 2024

The success of deep learning (DL) in offline brain-computer interfaces (BCIs) has not yet translated into efficient online applications. This is due to two limiting factors: the need for large amounts of training data in DL and the fact that current DL solutions are primarily developed for offline decoding. To enable real-time decoding, even across subjects without calibration data, we first introduce a novel method real-time adaptive pooling (RAP) to tune existing offline DL models towards online decoding by modifying the pooling layers. To reduce the amount of training data required, our approach leverages different levels of domain adaptation. We show how different settings enable different adaptation solutions. Our results demonstrate that our approach is both powerful and can be calibration-free, providing a robust and practical solution for real-time BCI applications. These findings pave the way for the development of co-adaptive and highly efficient DL-based BCI systems.
Current Trends on Unique Features and Role of Nanomaterials in Personal Care Products
Authors: Rathnasinghe Nimasha , Kaushani K.G. , Rajapakshe B.P.S. , Silva Awanthi De , Jayasinghe R.A. , Nilmini A.H.L.R , Tissera Nadeeka D , Wijesena Ruchira N , Priyadarshana Gayan
Published: August 2024

Nanotechnology has applications in a variety of scientific specialties, encompassing health, technological devices, and now cosmetics under the generic term of nanocosmetics. Due to the improved particle qualities, such as color, transparency, and solubility, acquired at the nanoscale, nanotechnology significantly affects the cosmetic industry. Skin penetration mechanism depends heavily on the nanoparticles' physicochemical properties, including stiffness, hydrophobicity, size, and charge. An expanding industry that requires more research and development has been created by nanoparticle production technologies. Liposomes, solid lipid nanoparticles, cubosomes, dendrimers, and other nanomaterials offer advanced skincare properties. Cosmetics made using nanotechnology have the advantages of product diversity, increased bioavailability of active compounds, and enhanced pleasing appearance of cosmetics with long-lasting benefits. The various cosmetic brands' utilization of various types of nanomaterials in their products is highlighted in this review.