bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel analysis method for calculating nonlinear Frequency Response Functions.
Authors: Maio Dario Di
Published: January 2025

This research presents a novel analysis method for calculating nonlinear Frequency Response Functions from a nonlinear frequency response surface (NFRS). The research aims to provide engineers with a user-friendly technique to evaluate the nonlinear frequency responses when the modal parameters as a function of the vibration amplitude are available. The Frequency Response Functions (FRFs) are the most widely used functions to characterise the dynamic behaviour of structures. The experimental modal analysis stands on four pillars 1) measurement, 2) identification, 3) regeneration, and 4) comparison, and these four steps must be ensured under linear and nonlinear vibrations. However, the nonlinear vibrations are challenging for identifying, regenerating, and comparing nonlinear FRFs. This research postulates that a nonlinear FRF solves a geometrical intersection between the nonlinear frequency response surface and any constant amplitude force surface. The paper demonstrates the hypothesis with ONE- and TWO-DoF systems with a cubic stiffness nonlinearity by showing how to generate a nonlinear frequency response surface when the force-displacement relationship is calculated. The verification of the proposed formulation is yielded by comparing nonlinear FRFs generated by the new analysis method (NM) to the ones generated by the Harmonic Balance Method and numerical integration. Furthermore, the paper presents a new identification method, based on the Dobson formulation, for extracting amplitude-dependent modal parameters. These parameters generate an NFRS, from which synthesised nonlinear FRFs are evaluated and compared to the experimental ones. The most important innovation of this research is that the four steps listed earlier can quickly be implemented with the proposed technique.
Numerical systems as the basis of number theory
Authors: Vechtomov E.M.
Published: January 2025

Various approaches to the definition and study of basic numerical systems are considered and analyzed. It is emphasized that numerical systems of natural numbers, integers, rational numbers, and real numbers serve as the basis for the study of number theory and number-theoretic research.

Рассматриваются и анализируются различные подходы к определению и изучению основных числовых систем. Подчеркивается, что числовые системы натуральных чисел, целых чисел, рациональных чисел и действительных чисел выступают в качестве основания для изучения теории чисел и теоретикочисловых исследований.
Декомпозиция расчетной области для численного решения уравнения Кана–Хиллиарда
Authors: Прохоров Д.И.
Published: January 2025

В статье представлен параллельный алгоритм для численного решения уравнения Кана–Хиллиарда в трехмерной постановке. В основе алгоритма лежит явная конечно-разностная схема и метод декомпозиции расчетной области. Для каждой подобласти выделяется один MPI-процесс, при этом решение внутри подобласти вычисляется с использованием технологии CUDA для GPU. Исследована сильная и слабая масштабируемость алгоритма в приложении к задаче разделения фаз для двух различных схем обмена данными между RAM и VRAM.

The article presents a parallel algorithm for the numerical solution of the Сahn–Hilliard equation in a three-dimensional formulation. The algorithm is based on an explicit finite difference scheme and a domain decomposition method. One MPI process is allocated for each subdomain, while the solution within the subdomain is calculated using CUDA technology for the GPU. The strong and weak scaling of the algorithm is investigated in application to the problem of phase separation for two different data exchange schemes between RAM and VRAM.
أثر أساليب إدارة التكلفة الاستراتيجية على دعم استمرارية شركات التصنيع الغذائي: دراسة على عينة من شركات التصنيع الغذائي بولاية الخرطوم
Authors: عبد الله محمد إسحق
Published: January 2025

هدفت الدراسة إلى معرفة أثر أساليب إدارة التكلفة الاستراتيجية على دعم استمرارية المنشأة بالقطاع الصناعي السوداني للأغذية من خلال أساليب إدارة التكلفة الاستراتيجية والمتمثلة في التكلفة المستهدفة، سلسلة القيمة ومحاسبة استهلاك الموارد. اعتمدت الدراسة المنهج الوصفي التحليلي. واستخدمت استمارة الاستقصاء لجمع البيانات الميدانية من العاملين بالقطاع الصناعي الغذائي بولاية الخرطوم بطريقة العينة القصدية من مجتمع الدراسة وهي إحدى العينات غير الاحتمالية والتي تتيح للباحث الحصول على معلومات من جهات محددة. استخدمت الدراسة تحليل المسار لاختبار فرضيات الدراسة. وتوصلت الدراسة إلى وجود علاقة ارتباط  طردي قوي بين أساليب إدارة التكلفة الاستراتيجية واستمرارية المنشأة. أوصت الدراسة بزيادة إدراك محاسبي التكاليف بالقطاع الصناعي السوداني بأهمية المعلومات المستمدة من أساليب إدارة التكلفة الاستراتيجية باعتبارها من الدعائم الأساسية لاستمرارية المنشآت الصناعية.
تأثير التسويق الإلكتروني على تجربة المعتمر: دراسة ميدانية
Authors: الحازمي باسم سعود , باعشن مشهور هاني , راجخان دانا منذر
Published: January 2025

هدفت هذه الدراسة إلى تحليل أثر التسويق الإلكتروني على تجربة المعتمرين في المملكة العربية السعودية، مع تسليط الضوء على الفوائد والتحديات المرتبطة بتطبيق أدوات التسويق الإلكتروني في قطاع العمرة. استُخدم المنهج الوصفي التحليلي في هذه الدراسة، وتم الاعتماد على استبانة كأداة رئيسية لجمع البيانات، حيث وزعت على عينة عشوائية شملت 200 معتمر. ركزت الدراسة على ثلاثة محاور رئيسة: البيئة المادية (وسائل النقل، الفنادق، المرافق العامة)، التفاعل مع الموظفين، والخدمات التكميلية. أظهرت النتائج وجود تأثير إيجابي وذي دلالة إحصائية للتسويق الإلكتروني على البيئة المادية والخدمات التكميلية، في حين لم يكن له تأثير واضح على التفاعل مع الموظفين. كما بينت النتائج أن التطبيقات الإلكترونية كانت الأداة الأكثر استخدامًا بين أدوات التسويق الإلكتروني، بينما كانت خدمات النقل من أكثر الخدمات التي استفاد منها المعتمرون عبر هذه الوسائل. استنادًا إلى النتائج، أوصت الدراسة بـ تعزيز الاستثمار في تطوير التطبيقات الإلكترونية لتحسين تجربة المستخدم، تطوير خدمات النقل المقدمة إلكترونيًا لتلبية احتياجات العملاء بشكل أفضل، تعزيز كفاءة التفاعل بين العملاء وموظفي خدمة العملاء، والاستمرار في تقديم خدمات تكميلية مبتكرة تلبي احتياجات المعتمرين، بما يساهم في تحسين تجربتهم الدينية والشخصية بشكل شامل.
Tunable Conformational Fluctuations of DNA Nanocages
Authors: Ferrell Jonathon , Shi Yutong , Shi Yu , Schneebeli Severin , Li Jianing
Published: January 2025

Wireframe DNA nanocages, an important type of DNA nanomaterials, exhibit exceptional programmability for chemical modifications, along with tunable size and shape. Nevertheless, the impact of their conformational fluctuations on cage design has not been thoroughly explored, despite speculation regarding its influence on biomedical applications. This study marks the first systematic examination of the conformational dynamics of prismatic DNA nanocages through molecular modeling and simulation. By comparing four different DNA nanocage topologies, we uncover design parameter combinations and conditions that facilitate access to varying conformational states. We observe the expansion and contraction of these cages across various topologies, hybridization states, and ionic environments (Mg2+/Na+), with their volumes varying from 15% to 150% of the ideal cage volumes. Our results indicate that the dynamics of DNA cages is influenced by the concentrations of Mg2+ and Na+ ions. Additionally, the flexibility of specific DNA strands can be manipulated, thereby altering the cage volume, through the selective hybridization of the cage edges. Ultimately, the conformational dynamics of DNA nanocages are captured in atomic detail. This study offers valuable modeling tools and methodologies to assist future DNA nanocage design endeavors.
ASSESSMENT OF SOIL AND PLANTS IN PRIVATE GARDENS OF AN INDUSTRIAL CITY
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Boluspayeva Laura , Abzhalelov Akhan , Spychalski Valdemar , Zhaznayeva Zhanat , Sarsenbayeva Gulmira
Published: January 2025

In this study, ecological evaluation of the soils of the private gardens located in the industrial area and in the suburban rural area was given. The results of physical and chemical analysis of soil samples were summarized, and the obtained data were statistically processed. Soil and vegetable samples for analysis were taken from private gardens located in the city near «Kazzinc» LLC. In ad-dition, samples were collected from the outskirts of the city – Akhmirova village for comparative analysis. These samples were prepared for chemical investigation to determine the content of Zn, Pb, Cu, and Cd.The findings revealed that the levels of heavy metals in the soils of the industrial area are several times higher than those in the suburban rural area. The average values of the analyzed metals in the industrial soils across all studied regions exceed the safe levels accepted in Kazakhstan. In the samples taken in the industrial area, the content of all investigated heavy metals was 2 to 8 times higher than the internationally recommended safe level. Despite being grown in the same environmental conditions, vegetables have different accumulation levels of heavy metals. However, it should be noted that high concentrations of heavy metals in the soil affect their content in plants. The highest levels of heavy met-als were found in vegetables grown in the industrial area, while the lowest levels were observed in the suburban area.
Ecogenetic assessment of the effects of technogenic pollutants on genome stability
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Bigaliyev Aitkhazha , Bekmanov Bakytzhan , Shalabaeva Clara , Kozhakhmetova Aizada , Myrzatay Ayaulym
Published: January 2025

The aimof the study is to assess the impact of radiation pollution on the stability of the genome and human health, taking into account the long-term genetic consequences.Measurements of gamma activity showed that the radiation level of the surveyed territory of the landfill and adjacent settlements is in the range of 0.06-0.014 mSv/h. Of particular importance in this regard is the study of the mechanisms of individual sensitivity to radiation and the role of the DNA repair system [1,36]. Molecular genetic studies of the DNA of blood cells and cytogenetic analyses of people living in the zone of influence of the radioactive waste landfill revealed the spread of several mutant genotypes, which indicates the likelihood of an increased risk of environmental diseases in persons with pronounced genome instability.The radiation level on the territory of the landfill and adjacent settlements is in the range of 0.06-0.014 mSv/h. By genotyping the XRCC1 Arg399Gln DNA repair gene, it was found: homozygous Arg/Arg (89+159), heterozygous Arg/Gln (248+159+89 ), homozygous Gln/Gln (248). The genotype dis-tribution is as follows: XRCC1 Arg/Arg – 15 people, XRCC1 Arg/Gln – 14 people, XRCC1 Gln/Gln – 1 person.
SCIENTIFIC-THEORETICAL ANALYSIS OF COMMERCIAL PREMISES LEASE AGREEMENT IN THE SYSTEM OF JURISPRUDENCE
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Alimkulova A.S. , Kaishataeva А.K. , Sartbyeva U.K. , Madalieva A.A.
Published: January 2025

In this article, we will consider the lease agreement for commercial premises in the system of Legal Sciences from the point of view of scientific and theoretical study. In the system of modern legal sciences, we determine the need for a scientific and theoretical study of the lease agreements of commercial premises by the following factors. Because: first of all, the object of study of the article is primarily studied by civil law within the system of Legal Sciences; secondly, in addition to the above-mentioned branch of law, other branches and institutions of the legal system are studied, in particular, contract law, Lease Law, Business Law, housing law, Construction Law, Land Law, private international law, etc; thirdly, experts are interested in the study of this topic in addition to these branches of law, which are now traditionally developed legal institutions of civil law, such as "property law", "property law", as well as "property law". Therefore, these branches of law and other legal institutions included in the system of Legal Sciences have a direct right to study in scientific and theoretical terms the lease agreement of these commercial premises. A comprehensive analysis of these issues will allow identifying existing problems and suggesting ways to solve them, which will contribute to the development of legal regulation in this area and ensuring a balance of interests between landlords and tenants.
MoS2 nanowires in-situ sputtered with Molybdenum Nitride nanoflakes for high-performance Na-ion Supercapacitors
Authors: Ranjan Bhanu , Kaur Davinder ,   Functional Nanomaterials Research Laboratory (FNRL), Department of Physics, Indian Institute of Technology Roorkee (IIT-Roorkee) Roorkee-247667, Uttarakhand, India
Published: January 2025

We report the fabrication of binder-free, low-cost, and efficient hybrid supercapacitive electrode based on the hexagonal phase of two-dimensional MoS2 nanowires reinforced with molybdenum nitride nanoflakes deposited on stainless steel (SS) substrate using reactive magnetron sputtering technique. The MoS2-Mo2N/SS nanostructured thin film working electrode delivers a high gravimetric capacitance (351.62 F/g at 0.25 mA/cm2) in 1M Na2SO4 aqueous electrolyte. The physisorption/intercalation of sodium (Na+) ions in electroactive sites of MoS2-Mo2N nanocomposite ensures remarkable electrochemical performance. The deposited porous nanostructure with good electrical conductivity and better adhesion with the current collector demonstrates excellent capacitance retention of 93.62% over 4000 Galvanostatic Charge-Discharge (GCD) cycles. The attractive merits of the MoS2-Mo2N nanocomposite electrode make it a promising candidate for high-performance supercapacitor applications.
The Role of Cancer Rehabilitation in Chemotherapy-Induced Sarcopenia
Authors: Moore Tracy , Bertram Jessica
Published: January 2025

Despite the well-documented multifactorial effects of cancer treatment, including anorexia, anemia, cancer-related fatigue, blunted immune and endocrine functioning, and biopsychosocial distresses, sarcopenia is not often recognized and assessed by healthcare staff. Recognizing and addressing this potential gap in care is extremely important for rehabilitation professionals working with individuals affected by cancer for many reasons, including the opportunity for preventative education and improved access to rehabilitative treatment.
The Lymphedema Treatment Act: Past, Present, and Future
Authors: Alexander Candace , Foster Leigh Ann , Gordon Susan , Shetye Runzun
Published: January 2025

Our understanding of time is often marked by important events specific to our lives. Some are major undertakings like the moon landing. Others are smaller like a first major league baseball game or stage recital. Some are so specific that only a small percentage of people will experience them, yet these can be both pivotal and substantial. The Lymphedema Treatment Act (LTA) may represent this event for many Certified Lymphedema Therapists (CLTs) and patients. It has opened up a more accessible world of compression care to patients who previously may have only had expensive out-of-pocket costs or charity assistance. It has also had unanticipated effects on clinical care and relationships with medical suppliers. This conversation will focus on the origins of the LTA, what the LTA includes as of January 2024, what the LTA means for therapists currently, and how this Act may impact the future of lymphedema care.
Perceptions and Outcomes of Older Adults Following a Cancer Prevention Educational Seminar
Authors: Boright Lori , Arena Sara , Wilson Christopher , Boardman Andrew , Chen Kevin , Soleimani Marcel , Wickersham Hannah
Published: January 2025

Introduction: 19.9 million new cancer cases and 9.7 million cancer deaths occurred globally in 2023. 90-95% of cancers originate from environment and lifestyle choices. Age is a prominent non-modifiable risk factor for cancer development, so it is essential that older adults are informed on lifestyle factors affecting their cancer risk. Physical therapists (PTs) play a major role in educating and advocating for healthy cancer preventive behaviors. The purpose of this study was to describe outcomes of an educational intervention relating to cancer prevention in community-dwelling older adults.

Methods: Investigators developed and delivered a cancer prevention educational seminar relevant to exercise, nutrition, sleep, stress management, and skin care. Twelve adults ≥ 65 years of age completed pre and post surveys. Data were analyzed using descriptive statistics. Comparison of variables between the pre and post surveys were performed to determine intervention impact using measures of central tendency. P-values were analyzed using a Wilcoxon matched pairs signed-rank test. Significance was set at ≤ .05.

Results: Statistically significant improvements in beliefs, confidence, and/or knowledge regarding prevention were noted in all topic areas.

Discussion: The educational seminar demonstrated positive outcomes for older adults’ knowledge, confidence, and attitudes about healthy behaviors to prevent cancer and underscores the necessity for preventive rehabilitative services provided by PTs.

Conclusion: A single-episode educational seminar on the prevention of cancer through the implementation of healthy behaviors in the domains of exercise, nutrition, sleep, stress management, and skin care can precipitate positive changes in knowledge, confidence, and perceptions of older, community-dwelling adults.
Editorial Volumen 10 Número 2
Authors: Carro Pérez Ennio Héctor
Published: January 2025

Editorial del Volumen 10 Número 2, julio-diciembre de 2019
Prufrock: The Delegate of Modern Man
Authors: Bhandary Amaresh Prasad , Quadir Abdul , Singh Vandana
Published: January 2025

The ‘Love Song of J. Alfred Prufrock,’ a great work of art by the great modern poet and critic T. S. Eliot, started in 1911 was published in 1917 after the publication of the “Preludes” (1915). It is considered, a dramatic monologue as Tennyson’s ‘Ulysess’ and has been composed in the pattern of Stream of Consciousness. It is the poetry of anguish against the growing materialism augmented by the impact of the World-War I (1914-1919). The trauma of the war lingered, making people apprehensive of the uncertainty of the situation and difference of the gigantic problems of life. Materialism and commercialism appeared to choke the human emotion and feelings that led the poets to attack the trend with wit and irony.
The Epigraph taken from Dante’s ‘Inferno’ forms the root image of the poem.  The Epigraph suggests the vagueness of the speaker’s thought but the images are quite distinct and the range of wit is very wide. The opening line of the poem with their colloquial language presents a break from Victorian poetry –
‘Let us go then You and I.’ [1]
Prufrock has nursed love in his heart but has not been able to convey his feelings to his beloved. He ponders:
‘we have lingered in the chambers of the sea.’ [2]
Time has moved to form a bald on the middle portion of his head, yet he has not been able and courageous enough to cough out his feelings to his beloved and nor he feels the need of a face to meet the ‘faces we meet.’
He is in the ‘Autumn’ of life advancing to ‘Winter’, yet is unable to express his love to his beloved, although he has been craving for the same since long and has been procrastinating and idle only fancying:
 ‘There will be time there will be time.’ [3]
 suggesting his belief that there is a reason for every happening, taking place everywhere.
He evaluates himself that he has lived a club life having no life force save the passing of days and has measured his life with ‘coffee-spoons.’
Prufrock suffers from inaction and indecision that reminds us of Hamlet, the prince of Denmark who had divided-self oscillating between ‘to be or not to be.’
O apagamento das danças guerreiras de origem negra no Brasil
Authors: Aguilar Gina MariaMonge , SatoTurtelli Larissa
Published: January 2025

O objetivo deste artigo é refletir sobre a Dança Negra Tradicional e Contemporânea em África, especificamente em Moçambique (XIGUBO) e África do Sul (INGOMA) e suas contribuições na formação das danças brasileiras de origens negra (Congada e Moçambique). O foco principal destas reflexões versa sobre o desaparecimento das danças guerreiras de origem negra no Brasil. Desaparecimento que deixou resquícios históricos de sua existência e de suas relações de técnicas corporais e de corporeidade com as danças supracitadas oriundas do continente africano. A maioria dos negros escravizados que chegaram em Pindorama, eram de origens BaNtu1, no entanto a importância da cultura e a influência BaNtu é invisibilizada em nossa história social. As danças Xigubo e Ingoma, são danças do povo Zulu, de origem BaNtu do sul do continente africano. As relações históricas e técnicas, são claramente percebidas em danças tradicionais de origem negras no Brasil, como nas danças: Congado, Moçambique e Maracatu, apenas para ficar nestas. Ao longo deste artigo, fundamentaremos a necessidade do colonialismo desenvolver estratégias para o apagamento da imagem da rainha Nzinga e do Rei de Congo nas danças tradicionais brasileiras de origem negra, danças estas, com cortejos referente a coroação e a união simbólica das duas nações Congo e Angola, pertencentes aos civilização de origem BaNtu. Estas estratégias foram pacientemente articuladas e desenvolvidas pelos donos de escravos e religiosos, aos longos dos anos, no século XVII e principalmente XVIII, transformando as danças guerreiras negras em uma procissão religiosa católica, o Rei de Congo foi substituído por São Benedito e a Rainha Nzinga por Nossa Senhora do Rosário. As consequências deste apagamento, pela substituição por imagens católicas, causaram profundos prejuízos identitários e de concepção de mundo das comunidades negras, que afeta, ainda hoje, não apenas a corporeidade e a dança, mas principalmente as relações sociais entre negros e brancos e o combate as políticas estruturais raciais e racistas, mantendo os privilégios de 522 anos da população branca em relação a população não branca e não asiática
Development of a Cost-Effective Plasma Thawer: A Potential Game-Changer in Blood Transfusion Technology
Authors: Shamrez Shahid  , Mujib Muhammad Danish Mujib , Rao Ahmad Zahid , Muhammad Abul Hasan  , Saad Ahmed Qazi
Published: January 2025

Plasma thawers are vital in healthcare, ensuring safe thawing of frozen plasma for life-saving transfusions. To address challenges such as specialized operator training and high initial costs in low-resource settings, we developed a cost-effective and efficient plasma thawer in Pakistan. The device consisted of two compartments: one dedicated to thawing plasma and equipped with a water-filled heater, a continuous temperature sensor, and an agitating frame for plasma bags, and the other housing the control box. Optimized thawing conditions were defined. The regulation of temperature and control of motors were coordinated through an Arduino microcontroller and relays which allowed users to set temperature limits through push buttons. Our device was able to thaw frozen plasma, accurately maintaining water temperature between 37-40°C. The samples were clear of solid and gelatinous particles, indicating no protein denaturation or overheating. A buzzer signaled the completion of each cycle. The microcontroller cut off power to the heater if the temperature exceeded the upper limit. Relays activated heater to maintain water temperature above the lower limit and activated DC motor which converted rotational motion into linear motion through gears. The device was 10 times more cost-effective compared to commercially available alternatives. We demonstrated that plasma can be thawed using our prototype without any negative influence on the plasma quality, presupposed that optimized settings defined for this plasma product are used. We plan to further assess plasma coagulation, inhibition activity and hemostatic potency.
Enamel hypoplasia in children with down syndrome
Authors: Bahtra Nuh Nurmatarahim Salam  , Dimas Prasetianto Wicaksono
Published: January 2025

Background: Dental anomalies introduce significant functional problem in both jaws and can be grouped based on the stage of dental development at which each anomaly is predicted to originate. Enamel hypoplasia, one of the dental anomalies, is a condition where a disturbance of enamel matrix secretion, defective calcification or defective maturation causes tooth crown surface defect. Various studies show the prevalence of enamel hypoplasia was around 30-40% and a rise in children with Down syndrome.

Objectives: This study aims to inform the readers about the correlation between enamel hypoplasia in children with Down syndrome.

Discussion: Enamel hypoplasia occurrence is related to several factors, such as hereditary and environmental. Studies showed, there is a link between mental retardation and enamel defects as a result of the correlation between the development of enamel and the development of the brain, which inhibits tissue growth and some degradation of the odontoblast which is required to induce pre-ameloblasts to become ameloblasts. It leads to the decrease of secrete enamel matrix and causes the disease. Enamel hypoplasia could also impact the quality of life in Down syndrome children which can aggravate their condition.

Conclusions: Studies have suggested associations with why Down syndrome could lead to enamel hypoplasia, even though there should be more comprehensive studies to establish a more definitive correlation between enamel hypoplasia and specific developmental characteristics in children with Down syndrome.
Enhanching Listening Skills By Using Digital-Assisted Platform
Authors: Moh. Raul Figo  , Aminah Suriaman  , Muhammad Arid  , Anjar Kusuma Dewi
Published: January 2025

This research aimed to determine whether the use of a digital-assisted platform could enhance the listening comprehension skills of eleventh-grade students at SMA Negeri 4 Sigi. The research used a quantitative method, adopting a quasi-experimental design. Data collection involved administering pre-tests and post-tests, with participants split into two distinct groups: an experimental group and a control group. The primary research instrument was a listening comprehension test. The researcher compared the students’ listening abilities before and after the experimental group received treatment using the digital-assisted platform. The results showed that the post-test t-count value (1.723) was greater than the t-table value (1.670) at a 0.05 significance level with 64 degrees of freedom. Based on this analysis, the null hypothesis (H0) was rejected, and the alternative hypothesis (Ha) was accepted. In other words, the findings indicate a statistically significant difference in post-test results between the experimental group and the control group. This suggests that the use of digital-assisted platforms has a positive and significant impact on students’ listening skills.
Assessing misconceptions in astronomy: The use of ordered multiple-choice items
Authors: Taasoobshirazi Gita , Sneha Sweta
Published: January 2025

This study pilots a unique test item known as the ordered multiple-choice (OMC) item. These OMC items were administered to two high school astronomy classrooms participating in a NASA classroom of the future: Astronomy village program. The OMC items were included on a pre- and post-test to assess common misconceptions in astronomy, as part of study employing a quasi-experimental design. Each answer choice in an OMC item is linked to varying levels of student understanding, allowing for diagnostic interpretation of student responses. Results from the items indicated that although students did improve in their levels of understanding at the end of the program, there were still gaps in the students’ knowledge. We anticipate these items will allow for a unique and comprehensive assessment of student understanding of science.
Uji Aktivitas Antibakteri Fraksi N-Heksana Daun Pepaya (Carica papaya Linn.) Terhadap Escherichia coli dan Staphylococcus aureus
Authors: Aprillia Hananing , Putra Pratama Nofran , Nur'Aini Purnamaningsih
Published: January 2025

Background: Infectious diseases are still a problem for the world of health. Infectious diseases are caused by viral, bacterial and parasitic infections. Inappropriate use of antibiotics in treating bacterial infections can cause antibiotic resistance effects. Prevention of the effects of resistance can be done by looking for natural antibiotic agents derived from plants. One of the potential medicinal plants as antibiotics is papaya leaf.
Objective: The objective of study was determine the antibacterial activity of the papaya leaf n-hexane fraction against Escherichia coli and Staphylococcus aureus and to determine the diameter zone of inhibition the papaya leaf n-hexane fraction at 20%; 40%; 60%; 80%; and 100% against Escherichia coli and Staphylococcus aureus.  
Method: Papaya leaf were extraction by using maceration method of 70% ethanol as solvent. Separation of compounds based on the level of polarity using fractionation method with n-hexane: water (1:1 v/v) solvent then carried out phytochemical screening and separation of compounds using TLC method. The antibacterial activity testing used by agar diffusion method  Kirby Bauer with the treatment group of papaya leaf n-hexane fraction with a concentration of 20%; 40%; 60%; 80%; and 100%, the positive control group used Ampicillin 10 ?g and the negative control group used Aquades.  
Result: Diameter zone of inhibition Escherichia coli and Staphylococcus aureus was smallest at 20% was 6,57 ± 0,15 mm and 6,69 ± 0,33 mm, while the diameter zone of inhibition the largest at 100% was 7,92 ± 0,23 mm and 7,94 ± 0,16 mm.
Conclusion: The papaya leaf n-hexane fraction concentration of 20%; 40%; 60%; 80%; and 100% had antibacterial activity against Escherichia coli and Staphylococcus aureus. The higher concentration then the larger diameter zone of inhibition formed.
EVALUATION OF THE POSSIBILITY OF FLUSHING OF DRIP IRRIGATION SYSTEMS WITH ELECTROCHEMICALLY ACTIVATED LOW-CONCENTRATION SALT SOLUTIONS
Authors: Romashchenko M. I. , Konakov B. I. , Timoshevskyi A. V. , Polishchuk V. V. , Kovalenko I. O.
Published: January 2025

The practice of using drip irrigation systems shows that contamination of drip outlets, including products of organic origin, is a serious threat to their reliable operation. In Ukraine, to combat such contamination, drip irrigation pipelines are flushed with environmentally hazardous 15% sodium hypochlorite AquaDoctor made in China. At the same time, there is evidence in the world practice of the possibility of effective use of environmentally friendly electrochemically activated low-concentrated saline solutions, in particular, anolyte, for such purposes. The analysis of the domestic market of disinfectants, bactericidal agents and antiseptics suggested that the anolyte "Crystal" produced by PE "Personnel Lux" (Kharkiv), which has a high biocidal effect. Kharkiv), which has a high biocidal activity at a mass total concentration of 0.1% of ADR, and electrochemically activated low-concentrated sodium hypochlorite "Secobren" with a hypochlorite content of up to 0.06% produced by "UKRTEK PRODUCT" LLC (Kyiv), which may have similar properties, can be used for flushing drip outlets.
Laboratory and field studies have been conducted to determine the possibility of flushing drip irrigation pipelines with electrochemically activated low-concentrated saline solutions to remove contamination of drip irrigation outlets with products of organic origin. The study was conducted during the flushing of drip irrigation pipelines with integrated drippers from ASSIF (METZER, Israel) with AquaDoctor, Crystal and Secobren disinfectants. Laboratory studies were conducted in the laboratory of the Institute of Plant Industry and Mechanics of the National Academy of Agrarian Sciences of Ukraine, accredited in the UkrSEPRO system, and field studies were conducted on subsurface drip irrigation systems in Cherkasy and Kyiv regions. For flushing in the field, the "Forced installation of supply and mixing of PUPS" developed by IRRIGATOR UKRAINE LLC was used.
The results of laboratory and field studies have shown that the washing capabilities of environmentally safe products "Kristal" and "Secobren" are comparable to those of environmentally hazardous hypochlorite "AquaDoctor". This makes it expedient to conduct further research to develop the technology of washing drip outlets depending on the nature and intensity of their pollution.
ANALYSIS OF THE IMPACT OF GLOBAL CLIMATE CHANGE TRENDS ON THE BLOOMING OF THE DNIPRO RIVER IN THE DNIPRO-DONBAS CANAL AREA
Authors: Onanko Y. A.
Published: January 2025

The hydrodynamic properties of a reservoir can affect the potential for cyanobacterial blooming. Slow-flowing or stagnant waters are more conducive to blooming stability. Therefore, water with a faster flow, more intensive mixing, or higher rotation speed is less likely to develop cyanobacterial blooming. The Kremenchutske and Kamianske reservoirs have an essential impact on the blooming of the Dnieper River in the Dnieper-Donbas Canal area. Their temperature regime in the warm season favors the development of zooplankton and phytoplankton. Aquatic vegetation is most common in shallow water. Water blooming is observed in summer, and this process covers up to 70% of the area of ​​reservoirs, especially in the southern part and bays, deteriorating water quality. Higher frequency and intensity of precipitation, accompanied by longer periods of drought, can create contribute greater nutrient mobility. Longer periods of high temperatures also contribute to this process, at that  there is no mixing of water layers.  Cyanobacteria can quickly utilize nutrients that enter water bodies due to rainfall. Strong winds can also affect the cyanobacteria population, pushing cyanobacterial cells and colonies towards the banks, where they accumulate.These reservoirs are located in the temperate continental climate zone and belong to water bodies that warm up well. That is due to their width, which makes wind mixing possible in the middle and lower parts of the reservoirs, as a result of which the temperature is distributed evenly and horizontally. To confirm and supplement the results of field studies, statistical processing of water quality indicators of the Dnipro River in the area of ​​the Dnipro-Donbas Canal was carried out. Trends were determined by regression analysis of time series of water quality indicators. The distribution was checked for normality using the Kolmogorov-Smirnov and Shapiro-Wilk tests. Correlation analysis was performed using the Pearson parametric method and the Spearman nonparametric method. The fluctation period was determined using the spectral Fourier transform method. The comprehensive analysis made it possible to establish the factors that are the main cause of water blooming in the studied area, which makes it possible to control the necessary water treatment processes.
ASSESSMENT OF THE EVAPOTRANSPIRATION COMPONENTS DYNAMICS IN DIFFERENT AGRO-CLIMATIC ZONES OF UKRAINE USING THE PENMAN-MONTEITH-LEUNING MODEL
Authors: Matiash T. V. , Butenko Ya. O. , Smirnov A. M. , Matiash E. I.
Published: January 2025

The results of the assessment of evapotranspiration (ET) and its components based on remote sensing data are presented in the paper. To obtain this assessment, a special software was developed, namely the scripts using the JavaScript programming language for remote data processing in the Google Earth Engine (GEE) cloud software environment. This software allows to adjust the Penman-Monteith-Leuning (PML) model for the conditions of Ukraine and visualize the spatial distribution of ET. The usage of the cloud capabilities of the service made it possible to access the collection of images and carry out their remote processing using the Penman-Monteith-Leuning algorithm calibrated according to the data of the global network of eddy covariance monitoring stations. The result of such an assessment was a composite mosaic - a spatially distributed generalized image of evapotranspiration and its three main components: transpiration from vegetation (Ec), evaporation from the soil (Es) and evaporation of precipitation intercepted by vegetation cover (Ei) on the territory of Ukraine for the 2020 growing season. Understanding the dynamics of these components helps to optimize the water resources use and develop effective irrigation schemes, especially in the climate change conditions. As a result of the analysis of the evapotranspiration components’ dynamics during the growing season, the most important component of evapotranspiration for different agro-climatic zones was determined.
However, the models, which are using remote data to estimate evapotranspiration dynamics, require additional validation and comparison with field measurements to improve their accuracy. Quantitative indicators obtained through modeling should be consistent with the data from ground-based greenhouse gas flows monitoring stations, which will contribute to the improvement of the methodology and its adaptation to the conditions of different agricultural regions. In addition, the use of the maps of geospatial distributed evapotranspiration allows to identify regions with increased transpiration and potential shortage of water resources. Such maps become a valuable tool for planning and forecasting water resources, which is critically important for the agricultural sector.
Assessment of the mutational status of leukemia cells in adult patients with acute myeloblastic leukemia with maturation using high-throughput sequencing
Authors:   Ural State Medical University, Ekaterinburg, Russia, Vinogradov A.V. ,   Sverdlovsk Regional Clinical Hospital No. 1, Ekaterinburg, Russia, Sazonov S.V. ,   Ural State Medical University, Ekaterinburg, Russia,   Institute of Medical Cell Technologies, Ekaterinburg, Russia
Published: January 2025

Introduction. The use of molecular genetic technologies has broadened the understanding of pathogenic mechanisms of leukemia. However, the incidence of acute myeloid leukemia in adult patients, when chemotherapy is effective for induction and maintenance of continuous molecular remission, does not exceed 30–40%. We aimed to assess the mutational status of leukemic cells in adult patients with acute myeloblastic leukemia with maturation using high-throughput sequencing.
Materials and methods. We examined bone marrow samples of 10 patients with acute myeloblastic leukemia with maturation being under medical observation at Sverdlovsk Regional Hematology Center in 2020–2023. The average age of the subjects was 58.7 years old. The detection of chimeric genes DEK-NUP214, RUNX1-RUNX1T1, MLLT3-MLL, BCR-ABL1, PML­RARA, and CBFB-MYH11 was performed using polymerase chain reaction technique. The mutations in FLT3 and NPM1 were detected with fragment analysis. The mutation profile of 141 genes was determined with high-throughput sequencing on an automatic MiSeqDx analyzer using the QIAseq Targeted DNA Human Myeloid Neoplasms Panel.
Results. Pathologically significant gene mutations were detected in leukemia cells of all subjects. The average number of genetic abnormalities found in leukemia cells with all the methods used was 3.6 per sample, with high-throughput sequencing showing 2.9 per sample. Mutations in DNMT3A and FLT3 were observed in the largest number of samples (n=4), whereas those in IDH2, NPM1, and RUNX1, as well as translocation t(8;21)(q22;q22) were found in 3 samples each. The implementation of high-throughput sequencing was of the greatest importance in acute myeloblastic leukemia with maturation with a normal karyotype and random chromosomal aberrations, where in most cases, it was possible to clarify the prognostic stratification based on the analysis of additionally identified gene mutations. The stratification of acute myeloblastic leukemia with maturation with specific anomalies associated with a favorable (n=3) or unfavorable (n=1) prognosis, as well as NPM1 insertions in combination with FLT3 duplications (n=2) remained unchanged although we detected pathologically significant gene mutations using high-throughput sequencing method.
Conclusion. Patients with acute myeloblastic leukemia with maturation with different mutational profiles are potential candidates for differentiated treatments ranging from standard chemotherapy and bone marrow transplantation to targeted drug therapies under clinical trials.
Keywords: acute myeloblastic leukemia with maturation, high-throughput sequencing, gene mutations, age
СУТНІСТЬ МЕТОДУ «ДЕБРИФІНГ» В КОНТЕКСТІ ФАХОВОГО ІНШОМОВНОГО СПІЛКУВАННЯ МАЙБУТНІХ ІТ ФАХІВЦІВ
Authors: Синекоп Оксана
Published: January 2025

Іншомовне навчання є найбільш ефективним, коли вчасно запускається процес аналізу отриманих результатів, обговорення позитивних і негативних сторін завершеного завдання. Дебрифінг слугує важливим інструментом у цьому відношенні, діючи як структурований механізм рефлексії, що покращує навчальний досвід. У статті висвітлено переваги (слугує універсальним інструментом для іншомовного навчання на власному досвіді; допомагає виробити траєкторію розвитку студента для досягнення короткострокових і довгострокових навчальних цілей; сприяє командній консолідації; є цінним для поглиблення розуміння та розвитку компетентностей в ІТ дисциплінах; розвиває вміння надання конструктивного зворотного зв'язку; створює простір емоційної підтримки) і недоліки дебрифінгу у професійно орієнтованому англомовному спілкуванні. Визначено базові принципи впровадження дебрифінгу у навчання англійської мови професійно орієнтованого спрямування. Перший принцип «відкритого спілкування» полягає в тому, що студенти вільно висловлюють свої думки по завершенню іншомовної комунікативної ситуації. Принцип «рефлексивного практикування» дає відповіді на запитання: що, чому і як відбулося у професійно орієнтованому іншомовному спілкуванні. Принцип «активізації критичного мислення» передбачає ретельний аналіз дій, заохочення учасників критично оцінювати свої дії та рішення, що веде до глибшого розуміння певної проблеми чи ситуації. Принцип «орієнтації на результат та відбору корегувальних стратегій» ґрунтується на важливості визначення конкретних навчальних цілей та виявлення необхідних компетентностей, які студенти повинні розвинути для досягнення короткострокових і довгострокових навчальних цілей. Також цей принцип базується на заохоченні учасників профісійно орієнтованого іншомовного спілкування окреслювати стратегії для посилення ефективності іншомовного спілкування та усунення недоліків у майбутніх комунікативних ситуаціях. Це дозволить створити ефективну навчальну траєкторію, що враховуватиме потреби студентів та сприятиме їхньому професійному розвитку. Інтегруючи ці принципи в освітній процес, викладачі можуть створити сприятливе середовище, яке заохочує діалог, рефлексію та постійне вдосконалення професійно орієнтованої іншомовної компетентності.
VOLLEYBALL AS A MEANS OF PROFESSIONALLY APPLIED PHYSICAL TRAINING IN HIGHER EDUCATION INSTITUTIONS FOR STUDENTS SPECIALIZING IN 141 ELECTRIC POWER, ELECTRICAL ENGINEERING, AND ELECTROMECHANICS
Authors: Cherednychenko Inna , Chukhlantseva Natalia , Lutsenko Serhii
Published: January 2025

Higher education institutions train qualified and competitive specialists who not only possess a certain level of knowledge, skills, and abilities but can also apply them practically to achieve their professional goals. According to the Standard of Higher Education of Ukraine, a bachelor’s degree requires 240 ECTS credits, of which at least 25% must be elective courses aimed at developing general and specific competencies in the speciality. One of the general competencies for the speciality 141 "Electric Power, Electrical Engineering, And Electromechanics" is the ability to use various types and forms of physical activity for active recreation and a healthy lifestyle. To support this competency, the elective course "Professional and Applied Physical Training (using volleyball)" was offered to senior students. The article theoretically substantiates and presents a program for bachelor's degree students aimed at developing professionally applied physical qualities and psychophysical functions, the levels of which determine the quality of a future specialist's duties. The developed program assumes students possess a foundational mastery of basic volleyball techniques, which served as a prerequisite for enrolling in the course. The content of the program takes into account the specifics of professional activity, which is characterized by a heavy load on visual, auditory, musculoskeletal, and tactile analyzers. The discipline 'Professional and Applied Physical Training (using volleyball)' is designed for 180 hours, including 14 hours of lectures, 60 hours of practical classes, 96 hours of independent work, and 10 hours of individual assignments and consists of five content modules. The main criteria for assessing the quality of mastering the discipline 'Professional and Applied Physical Training (using volleyball)' were recommended to be the dynamics of indicators of the development of physical qualities and abilities by the speciality.
University-business collaboration as perceived by leading academics: comparing and contrasting the two most innovative Czech regions
Authors: Kadlec Vojtěch , Blažek Jiří
Published: January 2025

This article compares the nature of academia-business collaboration in the two most innovative Czech regions, where the respective regional decision-makers and universities’ representatives differ sharply in their approaches towards the commercialization of academic knowledge. An analysis of the nature of collaboration between life-science researchers in two leading Czech universities and private companies has been performed to identify whether targeted support provided at the regional and university levels can make a real difference and can overcome hindrances from the national level. In particular, the article investigates the motivation and approaches of leaders of life-science research teams to cooperation with private companies, the perceived barriers impeding such cooperation, including the strength of demand for innovation in both analyzed regions. The research identified significant differences in the perception of barriers between life scientists in Prague and South Moravia, vindicating the positive role of the South Moravian innovation strategy. Thus, researchers in South Moravia no longer face barriers preventing the emergence of cooperation with the business sector, and instead they are concerned about obstacles that stand in the way of its more intensive development.
Constatarea situațiilor de plagiat în cazul tezelor de doctorat după Decizia Curții Constituționale nr. 364/2022. Propuneri pentru viitoarea Lege a Învățământului Superior
Authors:   Facultatea de Drept a Universității din București, IANCU Teodor-Radu
Published: January 2025

Considering the Decision of Constitutional Court No 364 from 2022, the activity of the National Council for the Attestation of University Degrees, Diplomas and Certificates (NCAUDDC) has been effectively blocked regarding the analysis of plagiarism suspicions in PhD theses that have been published more than a year ago. The article is meant, on one side, to analyze the legal framework that can allow NCAUDDC to continue its activity and, on the other side, to formulate proposals for the future Law of Higher Education that can be both constitutional and efficient.