bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Symptomatology, Clinical and Radiological Severity of COVID-19 on Pulmonary Function Test Results and Functional Capacity during Follow-Up among Survivors
Authors: Pietruszka-Wałęka Ewa , Rząd Michał , Żabicka Magdalena , Rożyńska Renata , Miklusz Piotr , Zieniuk-Lesiak Emilia , Jahnz-Różyk Karina
Published: December 2023

One of the most commonly observed complications after COVID-19 is persistent pulmonary impairment. The aim of this study was to evaluate the impact of individual factors during the acute phase of COVID-19 on subsequent pulmonary function test results. The study involved 46 patients who were admitted to hospital due to respiratory failure caused by SARS-CoV-2 and who were assessed during follow-up visits at 3 and 9 months after discharge. Patients were divided into two subgroups according to the severity of respiratory failure. The severe group included patients requiring mechanical ventilation or HFNOT. The results of the study showed that a severe course of the disease was associated with a lower FVC and a higher FEV1/FVC ratio 3 months after discharge (both p < 0.05). In addition, it has been revealed that the length of hospitalization is a factor that negatively impacts the FEV1, FVC and TLC values measured at follow-up after 3 months. Furthermore, the obtained results identify the presence of cough in the acute phase of the disease as a factor having a positive impact on several PFT parameters (especially the FEV1/FVC ratio) as well as the 6MWT outcome after 3 months. The FVC improved significantly (p < 0.05) between the follow-up visits. The findings may indicate that COVID-19-induced respiratory dysfunction is usually temporary and spontaneously resolves during recovery. Recovery is slower in those who required more intensive oxygenation. The results of this study may be useful in identifying patients who require more intensive and longer rehabilitation after COVID-19.
New Insights into Boxer’s Knuckle Injury of the Little Finger
Authors: Durand Sébastien , Christen Thierry , Ledoux Jean-Baptiste , Baillot Romain
Published: December 2023

Background: The original description of boxer’s knuckle injury of the fifth ray mentions that the injury occurs between the extensor digitorum communis (EDC) and the extensor digiti minimi (EDM). Subsequent reports claim similar findings. Anatomical studies show that the EDC of the fifth ray is absent in most patients, while the EDM is generally composed of two slips. We present a modification of the current description of boxer’s knuckle injury of the little finger based on the correlation between advanced preoperative 3D imaging and intraoperative findings. Methods: Five patients were investigated preoperatively using high-resolution ultrasound and 3D tendon reconstruction-based MR arthrography. Surgical exploration identified the lesion site relative to the EDM and EDC. Results: All patients had two slips of the EDM and no EDC to the fifth ray. The injury appeared as a longitudinal tear of the EDM between its two slips. The mean gap was 7.8 mm (range 4.5–10 mm) on the pathological side vs. 1.3 mm (range 1–2 mm) on the healthy contralateral side. Conclusions: We believe that previous descriptions of boxer’s knuckle of the fifth ray are inaccurate. High-resolution ultrasound and 3D reconstructions based on MR arthrography are reliable diagnostic tools allowing to locate the injury with precision.
Catecholaminergic Polymorphic Ventricular Tachycardia: Multiple Clinical Presentations of a Genetically Determined Disease
Authors: Jurisic Stjepan , Medeiros-Domingo Argelia , Berger Florian , Balmer Christian , Brunckhorst Corinna , Ruschitzka Frank , Saguner Ardan M. , Duru Firat
Published: December 2023

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, inherited heart rhythm disorder that is caused by variants in genes responsible for cardiac calcium homeostasis. The aim of this study was to analyze different genotype-specific clinical manifestations of this disease. Methods and Results: We analyzed five CPVT cases from our institution in the context of specific patient characteristics and genotype–phenotype correlations. In this cohort, three of the index patients were male. The median age at diagnosis was 11 (11–30) years, and median age at disease onset was 12 (12–33) years. Four index patients suffered from syncope, while one female index patient suffered from out-of-hospital cardiac arrest. Two index patients experienced concomitant atrial flutter and atrial fibrillation. Three patients received an implantable cardioverter defibrillator and one patient received an event recorder. All index patients had causative genetic variants in the RYR2-gene. Conclusions: This study presents various phenotypic presentations of patients with CPVT harboring different pathogenic variants in the RYR2 gene, some of which have not previously been described in published studies. Syncope was the most prevalent symptom on admission. Adjustment of beta-blocker therapy may be necessary due to side effects. Moreover, our work further highlights the common occurrence of atrial tachyarrhythmias in these patients.
Genotype–Phenotype Relationship among 785 Unrelated White Women with Inherited Congenital Factor VII Deficiency: A Three-Center Database Study
Authors: Halimeh Susan , Koch Lydia , Kenet Gili , Kuta Piotr , Rahmfeld Tess , Stoll Monika , Nowak-Göttl Ulrike
Published: December 2023

Background: Congenital factor VII (FVII) deficiency, a rare bleeding disorder resulting from mutations in the F7 gene with autosomal recessive inheritance, exhibits clinical heterogeneity that lacks a strong correlation with FVII:C levels. The objective of this study was to discern genetic defects and assess their associations with the clinical phenotype in a substantial cohort comprising 785 white women exhibiting FVII:C levels below the age-dependent cut-off percentage. Patients and Methods: Individuals with verified inherited factor VII deficiency underwent i) genotyping using the Sanger method and multiplex ligation-dependent probe amplification (MLPA) to identify F7 mutations, including common polymorphic variants. Additionally, they were ii) categorized based on clinical bleeding scores (BS). Thrombophilic variants and blood groups were also determined in the study participants. Results: The probands in this study encompassed both asymptomatic individuals (referred for a laboratory investigation due to recurrent prolonged prothrombin time; n = 221) and patients who manifested mild, moderate, or severe bleeding episodes (n = 564). The spectrum of bleeding symptoms included epistaxis, gum bleeding, gastrointestinal bleeding, hematuria, postoperative bleeding, and gynecologic hemorrhage. The median ISTH bleeding score (BS) recorded within a two-year period prior to the work-up was 2 (0–17). Notably, this score was significantly higher in symptomatic women compared to their asymptomatic counterparts (3 versus 0; p < 0.001). The corresponding PBAC score before hormonal treatment stood at 225 (5–1200), exhibiting a positive correlation with the ISTH BS (rho = 0.38; p = 0.001). Blood group O was more prevalent in symptomatic women compared to asymptomatic individuals (58 versus 42%; p = 0.01). Among the 329 women (42%), known and novel mutations in the F7 gene, encompassing coding regions, exon/intron boundaries, and the promoter region, were identified, while common polymorphisms were detected in 647 subjects (95%). Logistic regression analysis, adjusted for clinical and laboratory data (including blood group, FVII activity, the presence of F7 gene mutations and/or polymorphisms, thrombophilia status, and additional factor deficiencies) revealed that older age at referral (increase per year) (odds/95% CI: 1.02/1.007–1.03), the presence of blood group O (odds/95% CI: 1.9/1.2–3.3), and the coexistence of further bleeding defects (odds/95% CI: 1.8/1.03–3.1) partially account for the differences in the clinical bleeding phenotype associated with FVII deficiency. Conclusion: The clinical phenotype in individuals with FVII deficiency is impacted by factors such as age, blood group, and the concurrent presence of other bleeding defects.
Optimal Bell’s Palsy Treatment: Steroids, Antivirals, and a Timely and Personalized Approach
Authors: Rim Hwa Sung , Byun Jae Yong , Kim Sang Hoon , Yeo Seung Geun
Published: December 2023

Importance: The optimal treatment approach for patients with Bell’s palsy, a condition characterized by acute facial nerve palsy, remains unclear. The present study was designed to provide insights into the most effective treatment strategies, whether steroids alone or steroids plus antiviral agents, as well as the optimal timing of treatment initiation. Objective: To investigate the impact of treatment modalities and timing on the recovery rates of Bell’s palsy patients and to assess the roles of individual factors. Design, Setting, and Participants: This retrospective analysis included 1504 patients with Bell’s palsy who visited Kyung Hee University Hospital. Patients were divided based on the treatment modality (steroid monotherapy vs. combined steroid and antiviral therapy) and the timing of treatment initiation (≤72 vs. >72 h). Main Outcomes and Measures: The primary outcome was the recovery rate, as assessed by the House–Brackmann (HB) grade. Secondary outcomes included factors such as age, electroneurography (ENoG) and electromyography (EMG) results, and comorbid conditions. Results: A combined comparison of patients treated with steroids plus antivirals and steroids alone, stratified by treatment start time, showed that recovery rates were highest in patients who received steroid monotherapy initiated within 72 h (OR 2.36; p < 0.05). Patients with severe Bell’s palsy tended to benefit more from combined therapy when treatment was initiated within 72 h. The recovery rate was higher in patients who received steroid monotherapy than combined therapy (86.32% vs. 79.25%, p < 0.05). Initiating treatment beyond 72 h was associated with a higher recovery rate than starting treatment within 72 h (85.69% vs. 76.92%, p < 0.05). An evaluation of the factors affecting recovery showed that patients aged 20 to 39 years had a higher recovery rate than other age groups (OR 1.47; p < 0.05). Fairly predictive EMG results were associated with significantly higher recovery rates (OR 3.52; p < 0.05). Conclusions: These findings underscore the importance of individualized treatment approaches in Bell’s palsy management. Steroid monotherapy remains effective, although combined treatment may have potential advantages, especially in patients with more severe disease. The best treatment results were achieved when steroid treatment was administered within 72 h. Our results suggest that there may be more flexibility in the application of the 72 h treatment period if we consider the time of treatment initiation alone, but this should take into account patient behavior patterns and the limitations of retrospective analysis. Further research is warranted to validate these findings and refine treatment recommendations for patients with Bell’s palsy.
Lower Extremity Amputation and Peripheral Revascularisation Rates in Romania and Their Relationship with Comorbidities and Vascular Care
Authors: Ionac Stefan , Rogers Steven K. , Bondor Cosmina I. , Bowling Frank L. , Dragoi Iulia Iovanca , Ionac Mihai
Published: December 2023

(1) Background: This retrospective Romanian study aimed to calculate the rate of, and comparison between, amputation and revascularisation for patients with either cardiovascular or diabetic comorbidities. (2) Materials: In our hospital-based database, we analysed patient-level data from a series of 61 hospitals for 2019, which covers 44.9% of the amputation patients for that year. The national database is compiled by the national houses of insurance and was used to follow amputations and revascularisations between 2016 and 2021. (3) Results: During the six-year period, the mean number of amputations and revascularisations was 72.4 per 100,000 inhabitants per year for both groups. In this period, a decline in open-surgical revascularisation was observed from 58.3% to 47.5% in all interventions but was not statistically significant (r = −0.20, p = 0.70). The mean age of patients with amputation (hospital-based database) was 67 years. Of these patients, only 5.1% underwent revascularisation in the same hospital prior to amputation. The most common comorbidities in those undergoing amputations were peripheral arterial disease (76.8%), diabetes (60.8%), and arterial hypertension (53.5%). Most amputations were undertaken by general surgeons (73.0%) and only a small number of patients were treated by vascular surgeons (17.4%). (4) Conclusions: The signal from our data indicates that Romanian patients probably have a high risk of amputation > 5 years earlier than Western European countries, such as Denmark, Finland, and Germany. The prevalence of revascularisations in Romania is 64% lower than in the Western European countries.
Deployment Strategy Analysis for Underwater Geodetic Networks
Authors: Huang Wei , Qiu Runying , Zhou Jixuan , Xu Tianhe
Published: December 2023

Seafloor geodetic network (SGN) is the foundation for building an underwater positioning, navigation and timing (PNT) system. Traditional network deployment mainly focuses on the deployment of underwater sensor network nodes. However, for SGN, there is no surface buoy node and submarine buoy node, and the number of anchors is limited because it is quite expensive to fully cover large scale areas. To achieve wide coverage and good positioning service of each set of underwater base stations, we focus on the network design of a single set of reference stations in this paper. We propose several deployment plans for a local SGN and then analyze their service quality indicators by considering the stratification effect caused by non-uniformly distributed sound speed. To evaluate the performance of each topology of SGN, we compare their coverage range, horizontal dilution precision (HDOP) and accuracy performance of positioning tests. Based on the overall performance in our simulation, we believe that the star five-node topology is a good topology design under sufficient economic conditions.
The Role of Zone Models in the Numerical Prediction of Fire Scenario Outcomes Onboard Passenger Ships
Authors: Salem Ahmed , Mauro Francesco , Vassalos Dracos
Published: December 2023

Fire models are categorised as zone models and field models. Field models excel in accuracy, whereas zone models outperform field models in terms of computational time and cost efficiency. Through comparison between Consolidated Fire and Smoke Transport (CFAST), representing zone models, and Fire Dynamics Simulator (FDS), a benchmark field model, the research discussed in this paper investigates the feasibility of employing zone models to predict the consequences of a potential fire scenario on an accommodation deck of a reference small passenger ship. Such a comparison is the first attempt to study the differences between the two modelling techniques for cruise ships. The findings of this research indicate that CFAST predictions align well with FDS results in the room of fire origin, the cabin. However, the agreement between CFAST and FDS results gradually weakens when continuous spaces are modelled as contiguous compartments like in connected corridors. This study suggests that zone models can serve as a tool for conducting fast conservative comparisons between established rule-based designs and potential alternative designs, particularly concerning the life safety of crew and passengers of small passenger ships. Such simplified models adapt well to their possible future application to extensive safety risk analyses for passenger ships.
Ice-Induced Vibration Analysis of Offshore Platform Structures Based on Cohesive Element Method
Authors: Zhang Jianhua , Wang Xiaoyu , Sun Ke , Lai Yueqi , Gao Dianwei , Kang Won-Hee , Wang Bin , Wang Bingjun
Published: December 2023

This study conducted ice-induced vibration analysis on offshore platform structures using the cohesive element method (CEM). The efficacy of this method in simulating the interaction between sea ice and the platform structure is verified by comparing it with the Hamburg Ship Modeling Pool (HSVA) ice-breaking experiment. Subsequently, the vibration response of a sea-ice-jacket platform model is investigated under both unprotected conditions and with the presence of ice-breaking cones. The findings reveal that the motion response of offshore platforms exhibits a positive correlation with the impact velocity of the ice, while the sensitivity of this impact is found to be minimal. Furthermore, the influence of different ice directions on the vibration response of offshore platforms is significant, and the shielding effect has an important impact on the platform’s response. Notably, offshore platforms equipped with 52.5-degree cones demonstrate the most effective vibration reduction, reducing the maximum acceleration by 63% compared to unprotected configurations. It is worth mentioning that as the cone angle increases, the corresponding ice-breaking cone undergoes higher load-bearing.
Overexpression of ATP Synthase Subunit Beta (Atp2) Confers Enhanced Blast Disease Resistance in Transgenic Rice
Authors: Huang Qiang , Chen Chunyan , Wu Xiyang , Qin Yingfei , Tan Xinqiu , Zhang Deyong , Liu Yong , Li Wei , Chen Yue
Published: December 2023

Previous research has shown that the pathogenicity and appressorium development of Magnaporthe oryzae can be inhibited by the ATP synthase subunit beta (Atp2) present in the photosynthetic bacterium Rhodopseudomonas palustris. In the present study, transgenic plants overexpressing the ATP2 gene were generated via genetic transformation in the Zhonghua11 (ZH11) genetic background. We compared the blast resistance and immune response of ATP2-overexpressing lines and wild-type plants. The expression of the Atp2 protein and the physiology, biochemistry, and growth traits of the mutant plants were also examined. The results showed that, compared with the wild-type plant ZH11, transgenic rice plants heterologously expressing ATP2 had no significant defects in agronomic traits, but the disease lesions caused by the rice blast fungus were significantly reduced. When infected by the rice blast fungus, the transgenic rice plants exhibited stronger antioxidant enzyme activity and a greater ratio of chlorophyll a to chlorophyll b. Furthermore, the immune response was triggered stronger in transgenic rice, especially the increase in reactive oxygen species (ROS), was more strongly triggered in plants. In summary, the expression of ATP2 as an antifungal protein in rice could improve the ability of rice to resist rice blast.
Gut–Lung Axis in Focus: Deciphering the Impact of Gut Microbiota on Pulmonary Arterial Hypertension
Authors: Suswał Konrad , Tomaszewski Michał , Romaniuk Aleksandra , Świechowska-Starek Paulina , Zygmunt Wojciech , Styczeń Agnieszka , Romaniuk-Suswał Małgorzata
Published: December 2023

Recent advancements in the understanding of pulmonary arterial hypertension (PAH) have highlighted the significant role of the gut microbiota (GM) in its pathogenesis. This comprehensive review delves into the intricate relationship between the GM and PAH, emphasizing the influence of gut microbial composition and the critical metabolites produced. We particularly focus on the dynamic interaction between the gut and lung, examining how microbial dysbiosis contributes to PAH development through inflammation, altered immune responses, and changes in the gut–lung axis. Noteworthy findings include variations in the ratios of key bacterial groups such as Firmicutes and Bacteroidetes in PAH and the pivotal roles of metabolites like trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and serotonin in the disease’s progression. Additionally, the review elucidates potential diagnostic biomarkers and novel therapeutic approaches, including the use of probiotics and fecal microbiota transplantation, which leverage the gut microbiota for managing PAH. This review encapsulates the current state of research in this field, offering insights into the potential of gut microbiota modulation as a promising strategy in PAH diagnosing and treatment.
Influence of Physical Activity during Pregnancy on Maternal Hypertensive Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Barakat Rubén , Silva-Jose Cristina , Zhang Dingfeng , Sánchez-Polán Miguel , Refoyo Ignacio , Montejo Rocío
Published: December 2023

Gestational hypertension is a notable concern with ramifications for maternal and fetal health. Preemptive measures, including physical activity (PA), are crucial. There is a pressing need for comprehensive investigations into the impact of various forms of PA on hypertensive disorders. A systematic review and meta-analysis (CRD42022372468) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed. Our review exclusively considered randomized clinical trials (RCTs) between 2010 and 2023, using the following databases: EBSCO, including Academic Search Premier, Education Resources Information Center, PubMed/MEDLINE, SPORTDiscus, and OpenDissertations; Clinicaltrials.gov; Web of Science; Scopus; the Cochrane Database of Systematic Reviews; and the Physiotherapy Evidence Database (PEDro). The primary outcome was hypertensive disorders occurring during pregnancy (14 studies). Diagnosed preeclampsia (15 studies) and blood pressure levels were also examined (17 studies). PA during pregnancy was significantly associated with a reduced risk of hypertensive disorders (RR = 0.44, 95% CI = 0.30, 0.66). The data also indicate a positive correlation between PA during pregnancy and both systolic (MD = −2.64, 95% CI = −4.79, −0.49) and diastolic (MD = −1.99, 95% CI = −3.68, −0.29) blood pressure levels. The relationship between PA and the incidence of diagnosed preeclampsia did not demonstrate a statistically significant association (RR = 0.81, 95% CI = 0.59, 1.11; p = 0.20). Random effects were used for all analyses. PA during pregnancy promises to improve maternal health by reducing the risk of gestational hypertension and positively affecting systolic and diastolic blood pressure.
Robotic Hepatectomy plus Biliary Reconstruction for Bismuth Type III and Type IV Hilar Cholangiocarcinoma: State of the Art and Literature Review
Authors: Guadagni Simone , Comandatore Annalisa , Furbetta Niccolò , Di Franco Gregorio , Carpenito Cristina , Bechini Bianca , Vagelli Filippo , Ramacciotti Niccolò , Palmeri Matteo , Di Candio Giulio , Morelli Luca
Published: December 2023

Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III–IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this setting, the aim of this study is to evaluate the potential benefits of RAS in III–IV HC in terms of post-operative outcomes. Methods: We conducted a systematic review using the PRISMA checklist for article selection. We searched the PubMed database and included only studies with clinical data about the treatment of III–IV HC using RAS. Results: A total of 12 papers involving 50 patients were included. All cases were Bismuth IIIa (n = 18), IIIb (n = 27) or IV type (n = 5) and underwent hepatectomy with biliary confluence resection and reconstruction. The mean operative time was 500 minutes with a conversion rate of 4%. The mean hospital stay was 12.2 days, and the morbidity and 30-day mortality rate were 61.9% and 2%, respectively. Over a mean follow up period of 10.1 months, 9/18 cases experienced recurrence (50%). Conclusions: RAS for III–IV HC is safe and feasible, at least if performed by experienced surgeons on selected cases. The oncological outcomes appear acceptable, given the aggressiveness of this pathology, but further studies are needed to fully elucidate the exact role of robotics in this setting.
Evaluating the Performance of Real Estate Exchange-Traded Funds
Authors: Malhotra Davinder K.
Published: December 2023

This study examines the net monthly returns of real estate exchange-traded funds (ETFs) through various performance evaluation models and market situations. The results reveal that these ETFs generated positive alphas and outperformed benchmark indices in absolute returns. However, their performance varied across market conditions, demonstrating both outperformance and underperformance compared to U.S. and global stocks. During the COVID-19 pandemic, real estate ETFs displayed a decline, trailing behind U.S. and global equities in both absolute returns and risk-adjusted performance. This emphasized their vulnerability during economic crises. Utilizing the Carhart four-factor model, significant exposure of real estate ETFs to the stock market was observed. Moreover, an assessment of ETF portfolio managers’ skills indicated proficiency in security selection but limited capabilities in market timing.
Reduction in Data Imbalance for Client-Side Training in Federated Learning for the Prediction of Stock Market Prices
Authors: Shaheen Momina , Farooq Muhammad Shoaib , Umer Tariq
Published: December 2023

The approach of federated learning (FL) addresses significant challenges, including access rights, privacy, security, and the availability of diverse data. However, edge devices produce and collect data in a non-independent and identically distributed (non-IID) manner. Therefore, it is possible that the number of data samples may vary among the edge devices. This study elucidates an approach for implementing FL to achieve a balance between training accuracy and imbalanced data. This approach entails the implementation of data augmentation in data distribution by utilizing class estimation and by balancing on the client side during local training. Secondly, simple linear regression is utilized for model training at the client side to manage the optimal computation cost to achieve a reduction in computation cost. To validate the proposed approach, the technique was applied to a stock market dataset comprising stocks (AAL, ADBE, ASDK, and BSX) to predict the day-to-day values of stocks. The proposed approach has demonstrated favorable results, exhibiting a strong fit of 0.95 and above with a low error rate. The R-squared values, predominantly ranging from 0.97 to 0.98, indicate the model’s effectiveness in capturing variations in stock prices. Strong fits are observed within 75 to 80 iterations for stocks displaying consistently high R-squared values, signifying accuracy. On the 100th iteration, the declining MSE, MAE, and RMSE (AAL at 122.03, 4.89, 11.04, respectively; ADBE at 457.35, 17.79, and 21.38, respectively; ASDK at 182.78, 5.81, 13.51, respectively; and BSX at 34.50, 4.87, 5.87, respectively) values corroborated the positive results of the proposed approach with minimal data loss.
A Methodological Approach towards Cyber Risk Management in Land Administrations Systems
Authors: Blin Pierre-François , Aditya Trias , Santosa Purnama Budi , Claramunt Christophe
Published: December 2023

Cybersecurity risk management in land administration systems is crucial for maintaining the integrity of spatial cadastral data, which faces increasing threats owing to the digital transformation of LAS. This research validates the findings of this preliminary step in the form of a cyber risk management methodology that combines BPMN 2.0 with model business processes implemented by a compliance-based approach using EBIOS Risk Manager. A practical case of land parcel subdivision in Indonesia is analysed to serve as a proof of concept for our proposed methodology. Vulnerabilities are identified and are characterised by a concentration of manual tasks and the absence of systematic controls, resulting in significant risks to data integrity. These findings underscore the urgent need for a proactive approach to strengthen the cyber resilience of LAS. This study attempts to develop a fit-for-purpose reference methodology for cyber risk management specifically tailored to LAS to identify and treat vulnerabilities, threats, risks, and impacts.
Absence of Clausal Islands in Shupamem
Authors: Schurr Hagay , Kandybowicz Jason , Nchare Abdoulaye Laziz , Bucknor Tysean , Ma Xiaomeng , Markowska Magdalena , Tapia Armando
Published: December 2023

Decades-long research on islands has led to the conclusion that island constraints are candidates for language universals. A recent surge in research on islandhood in African languages has revealed some would-be island configurations that are transparent for A¯- dependency formation. In this article, we show that in Shupamem, all clausal configurations expected to have the status of opaque island domains fail to block the formation of long-distance A¯- dependencies involving object ex situ focus. In support of the claim that A¯- movement has occurred in such cases, we rely on evidence from three wh- movement diagnostics (weak crossover effects, reconstruction phenomena and quantifier float). Furthermore, we show that non-movement dependencies across purported island boundaries in the language are also possible through the licensing of “island”-internal negative concord items by external non-local negators. We conclude that clausal island effects fail to materialize in Shupamem ex situ focus constructions and negative concord item-licensing domains. Based on an exploratory typological survey of islands in African languages, we indicate a trend toward varying degrees of island permeability in the area, concluding that while Shupamem is not an isolated example, it features one of the most permissive grammars known to date in this respect.
Chronic Kidney Disease Interplay with Comorbidities and Carbohydrate Metabolism: A Review
Authors: Kushwaha Radha , Vardhan Pothabathula Seshu , Kushwaha Prem Prakash
Published: December 2023

Chronic kidney disease (CKD) poses a global health challenge, engendering various physiological and metabolic shifts that significantly impact health and escalate the susceptibility to severe illnesses. This comprehensive review delves into the intricate complexities of CKD, scrutinizing its influence on cellular growth homeostasis, hormonal equilibrium, wasting, malnutrition, and its interconnectedness with inflammation, oxidative stress, and cardiovascular diseases. Exploring the genetic, birth-related, and comorbidity factors associated with CKD, alongside considerations of metabolic disturbances, anemia, and malnutrition, the review elucidates how CKD orchestrates cellular growth control. A pivotal focus lies on the nexus between CKD and insulin resistance, where debates persist regarding its chronological relationship with impaired kidney function. The prevalence of insulin abnormalities in CKD is emphasized, contributing to glucose intolerance and raising questions about its role as a precursor or consequence. Moreover, the review sheds light on disruptions in the growth hormone and insulin-like growth factor axis in CKD, underscoring the heightened vulnerability to illness and mortality in cases of severe growth retardation. Wasting, a prevalent concern affecting up to 75% of end-stage renal disease (ESRD) patients, is analyzed, elucidating the manifestations of cachexia and its impact on appetite, energy expenditure, and protein reserves. Taste disturbances in CKD, affecting sour, umami, and salty tastes, are explored for their implications on food palatability and nutritional status. Independent of age and gender, these taste alterations have the potential to sway dietary choices, further complicating the management of CKD. The intricate interplay between CKD, inflammation, oxidative stress, and cardiovascular diseases is unraveled, emphasizing the profound repercussions on overall health. Additionally, the review extends its analysis to CKD’s broader impact on cognitive function, emotional well-being, taste perception, and endothelial dysfunction. Concluding with an emphasis on dietary interventions as crucial components in CKD management, this comprehensive review navigates the multifaceted dimensions of CKD, providing a nuanced understanding essential for developing targeted therapeutic strategies.
Effectiveness of a Standardized Combination of Intracameral Mydriatics and Anaesthetic on Mydriasis during Cataract Surgery with Coexisting Diseases
Authors: Dereń-Szumełda Joanna Katarzyna , Dorecka Mariola , Zandecki Łukasz , Mrukwa-Kominek Ewa
Published: December 2023

Purpose: To examine the effectiveness of a standardized combination of intracameral mydriatics and anesthetic (SCIMA) on mydriasis in patients with coexisting diseases such as diabetes mellitus (DM) and pseudoexfoliation syndrome (PXF) during phacoemulsification. Methods: Patients with cataract were included in the study if they achieved pupil dilation diameter ≥ 6.0 mm after the administration of mydriatic eyedrops (ME) during the first visit (V1). During the second visit (V2), pupil size measurements were obtained for phacoemulsification surgery with SCIMA. Effective mydriasis was defined as a pupil diameter ≥ 6.0 mm just prior to capsulorhexis without the use of additional pupil dilating agents. The measurements after ME administration during V1 and after SCIMA use during V2 were compared. Results: 103 patients (103 eyes) were divided into 3 groups: cataract and DM (n = 35), cataract and PXF (n = 32), and cataract without DM or PXF (n = 36). SCIMA administration allowed the achievement of effective mydriasis (≥6.0 mm) in all groups (n = 103; 100%). Mydriasis was significantly larger (p ≤ 0.001) after ME (7.3 mm) than after SCIMA (6.8 mm) administration. Conclusions: Patients with cataract and such comorbidities as DM or PXF are likely to achieve effective pharmacological mydriasis during cataract phacoemulsification after SCIMA application. Mydriasis after ME is slower and larger, while SCIMA is faster.
CYP27B1 Enzyme in Psoriasis: A Preliminary Study of Immunohistochemical Observations
Authors: Paliu Iulia-Alexandra , Olinca Maria-Victoria , Ianosi Simona-Laura , Georgescu Claudia-Valentina , Turcu-Stiolica Adina , Diaconu Magdalena , Dumitrescu Cristiana-Iulia , Tica Andrei-Adrian
Published: December 2023

Connections between vitamin D and psoriasis have been a matter of interest for the past decades, with its active metabolite, 1,25(OH)2 vitamin D, being valued for antiproliferative and immunomodulatory effects. However, none of vitamin D’s actions could be possible without the CYP27B1 enzyme that bio-activates this metabolite of interest. In order to see if there is any link between the enzyme expression and the disease’s particularities, we conducted a preliminary study that involved 11 skin biopsies of patients with mild (n = 4) or moderate to severe psoriasis (n = 7). The cell proliferation antigen Ki67 and the CD45RO+ marker were also assessed. Compared with healthy skin, in psoriasis, it is reported that the enzyme’s expression seems to be more ubiquitous, but a clear correlation between the disease’s severity and the CYP27B1 expression was, to our knowledge, lacking. We found that, in patients with very mild psoriasis, the enzyme expression was observed in the epidermal stratum basale in a similar manner as in healthy skin specimens. Contrary, for higher severity scores, a divergent result was observed, with the enzyme being either variably spread in the epidermal stratum spinosum or completely absent. Unlike malignant diseases, a significant connection between CYP27B1 and Ki67 (p = 0.313) or CYP27B1 and CD45RO+ (p = 0.657) does not seem to be relevant in psoriasis.
Impact of Pelvic Fracture on Patients with Blunt Bowel Mesenteric Injury: Is Immediate Laparotomy Warranted?
Authors: Hsieh Ting-Min , Chuang Po-Chun , Liu Chun-Ting , Wu Bei-Yu , Wu Chien-Hung , Cheng Fu-Jen
Published: December 2023

The management of blunt abdominopelvic trauma with combined hemoperitoneum and pelvic fractures is challenging for trauma surgeons. Although angioembolization can achieve hemostasis in most visceral organ injuries and pelvic fractures after blunt abdominal trauma, it cannot effectively control hemorrhage in patients with blunt bowel mesenteric injury (BBMI). This study aimed to determine the risk factors associated with hemodynamically unstable patients with BBMI and to test the hypothesis that pelvic fracture is an independent risk factor for patients with unstable BBMI and concomitant pelvic fracture to guide the therapeutic sequence for difficult-to-manage patients. This retrospective study reviewed the data of hospitalized patients with trauma between 2009 and 2021 and included 158 adult patients with surgically proven BBMI. The patients were divided on the basis of the presence of a shock episode before emergency laparotomy. The shock group included 44.3% of all patients in the study (n = 70). Clinical injury severity and prognosis for patients in the shock group were poorer than those for patients in the non-shock group, and more invasive treatments and transfusions were performed for patients in the shock group than for those in the non-shock group. Pelvic fractures were more frequently associated with the shock group than with the non-shock group (21.4% vs. 5.7%; p = 0.003). In multivariate analysis, the presence of intracerebral hemorrhage (odds ratio [OR] = 10.87, 95% confidence intervals [CIs]: 1.70–69.75) and rib fracture (OR = 5.94, 95% CIs = 1.06–33.45) was identified as an independent predictor of shock, whereas the effect of pelvic fracture did not achieve statistical significance (OR = 2.94, 95% CIs = 0.66–13.13) after adjusting for confounding factors. For patients with BBMI, outcomes need to be improved during early diagnosis, and treatments should be expeditiously performed on the basis of the rapid identification of unstable hemodynamic status. Our results support the recommendation of emergency laparotomy in unstable patients with concomitant pelvic fractures, followed by damage control TAE if needed.
Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation
Authors: Aponte Pedro M. , Gutierrez-Reinoso Miguel A. , Garcia-Herreros Manuel
Published: December 2023

This review aims to explore advanced reproductive technologies for male fertility preservation, underscoring the essential role that animal models have played in shaping these techniques through historical contexts and into modern applications. Rising infertility concerns have become more prevalent in human populations recently. The surge in male fertility issues has prompted advanced reproductive technologies, with animal models playing a pivotal role in their evolution. Historically, animal models have aided our understanding in the field, from early reproductive basic research to developing techniques like artificial insemination, multiple ovulation, and in vitro fertilization. The contemporary landscape of male fertility preservation encompasses techniques such as sperm cryopreservation, testicular sperm extraction, and intracytoplasmic sperm injection, among others. The relevance of animal models will undoubtedly bridge the gap between traditional methods and revolutionary next-generation reproductive techniques, fortifying our collective efforts in enhancing male fertility preservation strategies. While we possess extensive knowledge about spermatogenesis and its regulation, largely thanks to insights from animal models that paved the way for human infertility treatments, a pressing need remains to further understand specific infertility issues unique to humans. The primary aim of this review is to provide a comprehensive analysis of how animal models have influenced the development and refinement of advanced reproductive technologies for male fertility preservation, and to assess their future potential in bridging the gap between current practices and cutting-edge fertility techniques, particularly in addressing unique human male factor infertility.
Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factor Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels
Authors: Minisini Martina , Cricchi Emanuele , Brancolini Claudio
Published: December 2023

O2 is essential for the life of eukaryotic cells. The ability to sense oxygen availability and initiate a response to adapt the cell to changes in O2 levels is a fundamental achievement of evolution. The key switch for adaptation consists of the transcription factors HIF1A, HIF2A and HIF3A. Their levels are tightly controlled by O2 through the involvement of the oxygen-dependent prolyl hydroxylase domain-containing enzymes (PHDs/EGNLs), the von Hippel–Lindau tumour suppressor protein (pVHL) and the ubiquitin–proteasome system. Furthermore, HIF1A and HIF2A are also under the control of additional post-translational modifications (PTMs) that positively or negatively regulate the activities of these transcription factors. This review focuses mainly on two PTMs of HIF1A and HIF2A: phosphorylation and acetylation.
Association between Sarcopenia and Reduced Bone Mass: Is Osteosarcopenic Obesity a New Phenotype to Consider in Weight Management Settings?
Authors: De Lorenzo Antonino , Itani Leila , Gualtieri Paola , Pellegrini Massimo , El Ghoch Marwan , Di Renzo Laura
Published: December 2023

Sarcopenic obesity (SO) is a frequent phenotype in people with obesity; however, it is unclear whether this links with an impaired bone status. In this study, we aimed to investigate the association between SO and low bone mass, and to assess the prevalence of a new entity that combines excessive fat deposition, reduced muscle mass and strength, and low bone mass defined as osteosarcopenic obesity (OSO). Body composition was completed by a DXA scan in 2604 participants with obesity that were categorized as with or without SO, and with low or normal bone mineral content (BMC). Participants with both SO and low BMC were defined as OSO. Among the entire sample, 901 (34.6%) participants met the criteria for SO. This group showed a reduced mean BMC (2.56 ± 0.46 vs. 2.85 ± 0.57, p < 0.01) and displayed a higher prevalence of individuals with low BMC with respect to those without SO (47.3% vs. 25.9%, p < 0.01). Logistic regression analysis showed that the presence of SO increases the odds of having low BMC by 92% [OR = 1.92; 95% CI: (1.60–2.31), p < 0.05] after adjusting for age, body weight, and body fat percentage. Finally, 426 (16.4%) out of the total sample were affected by OSO. Our findings revealed a strong association between SO and reduced bone mass in adults with obesity, and this introduces a new phenotype that combines body fat, muscle, and bone (i.e., OSO) and appears to affect 16% of this population.
Microcrystallization Effects in Borosilicate Bioactive Glasses: Controllable Release of Bioactive Elements and In Vitro Degradation Properties
Authors: Jin Chengyun , Zhang Minhui , Lin Jian
Published: December 2023

Borosilicate bioactive glasses exhibit excellent bioactivity and degradation properties; however, they suffer from the rapid release of bioactive elements at the initial stage of their degradation. Excessive local concentrations (such as those of B) can affect cell proliferation. Moreover, the degradation and mineralization ability of these glasses deteriorate at the later stages. Aiming to balance the release of bioactive elements during the whole process, herein, a borosilicate bioactive glass 18SiO2–6Na2O–8K2O–8MgO–22CaO–2P2O5–36B2O3 (mol%) was prepared using the melting method. Further, the effects of microcrystallization on the release of bioactive elements and in vitro degradation were studied. Results show that after heat treatment at temperatures over 620 °C, multiple microcrystalline phases, including Ca2SiO4, CaB2O4, and CaMgB2O5, form in the glass. The glass samples heat-treated within the range of 620–640 °C undergo appropriate devitrification degrees, decelerating the rate of pH increase of the immersion solution during the initial stage in comparison to those treated at lower temperatures. This results in a more continuous release of all bioactive elements and allows better control of the overall degradation. Contrarily, the more extensive devitrification degrees of glass samples heat-treated at higher temperatures reverse the pH increase and degradation trends. Since bone marrow mesenchymal stem cells and mouse embryonic osteoblast cells are pH-sensitive, inducing a suitable degree of devitrification proved to favor cell viability and enhance the mineralization capacity. Thus, different microcrystallization degrees provide new approaches for controlling the degradation and release of bioactive elements, resulting in the simultaneous enhancement of biosafety and bioactivity.
Transport Mechanism of Paracetamol (Acetaminophen) in Polyurethane Nanocomposite Hydrogel Patches—Cloisite® 30B Influence on the Drug Release and Swelling Processes
Authors: Strankowska Justyna , Grzywińska Małgorzata , Łęgowska Ewelina , Józefowicz Marek , Strankowski Michał
Published: December 2023

This article describes the swelling and release mechanisms of paracetamol in polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite). The transport mechanism, swelling and release processes of the active substance in nanocomposite matrix were studied using gravimetric and UV-Vis spectroscopic methods. Swelling and release processes depend on the amount of clay nanoparticles in these systems and the degree of crosslinking of PU/PEG/Cloisite® 30B hydrogel nanocomposites. The presence of clay causes, on the one hand, a reduction in free volumes in the polymer matrices, making the swelling process less effective; on the other hand, the high swelling and self-aggregation behavior of Cloisite® 30B and the interactions of paracetamol both with it and with the matrix, cause a change in the transport mechanism from anomalous diffusion to Fickian-like diffusion. A more insightful interpretation of the swelling and release profiles of the active substance was proposed, taking into account the “double swelling” process, barrier effect, and aggregation of clay. It was also proven that in the case of modification of polymer matrices with nanoparticles, the appropriate selection of their concentration is crucial, due to the potential possibility of controlling the swelling and release processes in drug delivery patches.
Research Progress on Inactivation of Bacteriophages by Visible-Light Photocatalytic Composite Materials: A Mini Review
Authors: Zhao Deqiang , Lu Heng , Cheng Qingkong , Huang Qi , Ai Jing , Zhang Zhibo , Liu Hainan , He Zongfei , Li Qiuhong
Published: December 2023

Infectious diseases caused by waterborne viruses have attracted researchers’ great attention. To ensure a safe water environment, it is important to advance water treatment and disinfection technology. Photocatalytic technology offers an efficient and practical approach for achieving this goal. This paper reviews the latest studies on visible-light composite catalysts for bacteriophage inactivation, with a main focus on three distinct categories: modified UV materials, direct visible-light materials and carbon-based materials. This review gives an insight into the progress in photocatalytic material development and offers a promising solution for bacteriophage inactivation.