bluuebunny/crossref_metadata_2025 huggingface dataset:
Site and Enantioselective Aliphatic C−H Oxidation with Bioinspired Chiral Complexes
Authors: Costas Miquel
Published: October 2021

Selective oxidation of aliphatic C−H bonds stands as an unsolved problem in organic synthesis, with the potential to offer novel paths for preparing molecules of biological interest. The quest for reagents that can perform this class of reactions finds oxygenases and their mechanisms of action as inspiration motifs. Among the numerous families of synthetic catalysts that have been explored, complexes with linear tetraazadentate ligands combining two aliphatic amines and two aromatic amine heterocycles display a structural versatility proven instrumental in the design of C−H oxidation reactions showing site and enantioselectivities, not accessible by conventional oxidants. This manuscript makes a review of recent advances in the field.
Determination of frequency, multiple antibiotic resistance index and resistotype of Salmonella spp. in chicken meat collected from southeast of Iran
Authors: Mir Reza , Salari Saeed , Najimi Mohsen , Rashki Ahmad
Published: October 2021

Background

Zoonotic food‐borne pathogens such as Salmonella spp., which can be hosted by some raw foods, play a crucial role in ranking the public health of a country

Objectives

The present study was conducted to assess the frequency, antibiotic resistance pattern and index of multiple antibiotic resistance (MAR) of Salmonella spp. in chicken meat

Methods

A cross‐sectional survey was conducted from October 2017 to March 2018. One‐hundred and fifty chicken meat samples were collected from meat stores in Zahedan, southeast of Iran and screened for contamination with Salmonella spp. using the polymerase chain reaction assay targeting the inv‐A gene. Antimicrobial susceptibility testing was performed against 11 commonly prescribed antimicrobial agents in the veterinary treatment to calculate the MAR index

Results

The contamination rate was 2.7% (4/150). The antimicrobial resistance rate was 100% (n = 4) against penicillin, tylosin, tetracycline, erythromycin and tiamulin, 50% (n = 2) against trimethoprim/sulfamethoxazole, difloxacin and lincomycin/spectinomycin and 25% (n = 1) against flumequine and florfenicol. All isolates were sensitive to fosfomycin. Interestingly, all isolates (n = 4) exhibited different MAR patterns. Furthermore, the MAR index ranged from 0.45 to 0.81

Conclusions

In addition to the MAR index, which indicated that the isolate originated from a source where antibiotics were used to a great degree and/or in large amounts, the results showed that the chicken meat hosted resistant strains of Salmonella spp. in the study area. Overall, the findings indicated an important public health problem. To reduce this alarming signal, the poultry industry should implement control measures in the study area.
Effect of functionalized silicon carbide nano‐particles as additive in cross‐linkedPVAbased composites for vibration damping application
Authors: Bisht Nitesh , Verma Akarsh , Chauhan Sakshi , Singh Vinay Kumar
Published: October 2021

In this research study, a comprehensive effort has been made to functionalize silicon carbide particles using the acidic oxidation with nitric acid to obtain homogeneous stabilized distribution of activated SiC particles within a polymer matrix, and develop functionalized silicon carbide (f‐SiC) particle reinforced polyvinyl alcohol (PVA) based cross‐linked composite. After fabrication of functionalized silicon carbide (f‐SiC) particle reinforced polyvinyl alcohol based cross‐linked composite with varying f‐SiC weight percentages of PVA (0%, 1%, 2%, 3%, and 4%) were placed to various investigations. Processed samples are initially examined based by the physical tests (water absorption tests), followed by mechanical test (tensile test) and then micro‐structural tests (scanning electron microscopy). Lastly, thermal tests were also concluded which involved the dynamic mechanical, differential thermal and thermo gravimetric analysis. The cross‐linked polyvinyl alcohol‐based composite with 2 weight % of f‐SiC content is observed to be the superlative of all the compositions under this research study that was confirmed by the mechanical and micro‐structural tests. This composite material shows high storage modulus with visco‐elastic behavior, therefore, the material can be utilized to diminish the transmission of noise, as a shock absorber and vibration isolator.
Fishing Livelihoods and Fisheries Governance
Authors: Fabinyi Michael , Barclay Kate
Published: October 2021

This book centres on an understanding of fishing livelihoods within processes of historical change, and the social and political relationships within which they are embedded. Drawing on our research experience from the Asia-Pacific region, we examine where fishing livelihoods have come from, and where they are going. This introductory chapter introduces fishing livelihoods and the governance challenge that they face, before examining social science research in greater depth. We then develop the idea of a relational approach to fishing livelihoods, describing how they are shaped by wider political and economic trajectories, by local social relationships and by institutional structures.
Responding to Global Change
Authors: Fabinyi Michael , Barclay Kate
Published: October 2021

This chapter focuses on the wider processes of political-economic change that drive key characteristics of fishing livelihoods. Globalisation has dramatically expanded the scale and accelerated the pace of fisheries capture and trade, generating new opportunities and challenges for livelihoods and marine environments. Here we document some of the major characteristics of the history of fishing across the Asia-Pacific, before focusing on case studies of the Philippines and PNG. We highlight three related features of globalisation that have influenced fishing livelihoods and that continue to shape them today: migration, engagement with markets and new technologies, and interactions with other forms of economic activity, including those outside the fisheries sector.
Fishing Livelihoods and Wellbeing
Authors: Fabinyi Michael , Barclay Kate
Published: October 2021

The final chapter of this book discusses the implications of a relational approach to fishing livelihoods for governance for improved social and ecological outcomes. The chapter reviews some of the ways in which academics, activists and policymakers can use approaches that emphasise the relational context of fishing livelihoods, and specifies the concept of wellbeing as one that can usefully and practically build bridges between fisheries stakeholders with diverse interests. The chapter then examines two assessments of fisheries on community wellbeing: the social and economic impacts of fisheries in Australia, and the effects of governance on wellbeing of fishing communities in Indonesia and Solomon Islands.
Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats
Authors: Bergh Marianne Skov-Skov , Bogen Inger Lise , Garibay Nancy , Baumann Michael H.
Published: October 2021

Background

Illicitly manufactured fentanyl and its analogs are a major driving force behind the ongoing opioid crisis. Cyclopropylfentanyl is a fentanyl analog associated with many overdose deaths, but limited knowledge is available about its pharmacology. In the present study, we developed a bioanalytical method for the determination of cyclopropylfentanyl and its main metabolite cyclopropylnorfentanyl and evaluated pharmacokinetic-pharmacodynamic relationships in rats.

Method

An ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for determination of cyclopropylfentanyl and cyclopropylnorfentanyl in rat plasma. Male Sprague–Dawley rats fitted with jugular catheters and temperature transponders received cyclopropylfentanyl (30, 100, and 300 μg/kg) or saline subcutaneously. Blood specimens were withdrawn over an 8-h time period, along with measurements of pharmacodynamic endpoints.

Results

The analytical method was validated, and both analytes exhibited a low limit of quantification (15 pg/mL). Cyclopropylfentanyl caused dose-related increases in hot plate latency (ED50 = 48 µg/kg) and catalepsy (ED50 = 87 µg/kg) and produced long-lasting hypothermia at the highest dose. Plasma cyclopropylfentanyl rose rapidly in a dose-related fashion, reaching maximal concentration (Cmax) after 15–28 min, whereas metabolite Cmax occurred later at 45–90 min. Cyclopropylfentanyl Cmax values were similar to concentrations measured in non-fatal intoxications in humans; however, differences in parent drug: metabolite ratio indicated possible interspecies variance in metabolism.

Conclusion

Our study shows that cyclopropylfentanyl produces typical opioid-like effects in male rats. Cyclopropylfentanyl displays much greater analgesic potency when compared to morphine, suggesting that cyclopropylfentanyl poses increased overdose risk for unsuspecting users.
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis
Authors: Diaz-Garcia Sandra , Ko Vivian I. , Vazquez-Sanchez Sonia , Chia Ruth , Arogundade Olubankole Aladesuyi , Rodriguez Maria J. , Traynor Bryan J. , Cleveland Don , Ravits John
Published: October 2021

Amyotrophic lateral sclerosis is a progressive fatal neurodegenerative disease caused by loss of motor neurons and characterized neuropathologically in almost all cases by nuclear depletion and cytoplasmic aggregation of TDP-43, a nuclear RNA-binding protein (RBP). We identified ELAVL3 as one of the most downregulated genes in our transcriptome profiles of laser captured microdissection of motor neurons from sporadic ALS nervous systems and the most dysregulated of all RBPs. Neuropathological characterizations showed ELAVL3 nuclear depletion in a great percentage of remnant motor neurons, sometimes accompanied by cytoplasmic accumulations. These abnormalities were common in sporadic cases with and without intermediate expansions in ATXN2 and familial cases carrying mutations in C9orf72 and SOD1. Depletion of ELAVL3 occurred at both the RNA and protein levels and a short protein isoform was identified, but it is not related to a TDP-43-dependent cryptic exon in intron 3. Strikingly, ELAVL3 abnormalities were more frequent than TDP-43 abnormalities and occurred in motor neurons still with normal nuclear TDP-43 present, but all neurons with abnormal TDP-43 also had abnormal ELAVL3. In a neuron-like cell culture model using SH-SY5Y cells, ELAVL3 mislocalization occurred weeks before TDP-43 abnormalities were seen. We interrogated genetic databases, but did not identify association of ELAVL3 genetic structure with ALS. Taken together, these findings suggest that ELAVL3 is an important RBP in ALS pathogenesis acquired early and the neuropathological data suggest that it is involved by loss of function rather than cytoplasmic toxicity.
Spinneret geometry modulates the mechanical properties of man-made cellulose fibers
Authors: Moriam Kaniz , Sawada Daisuke , Nieminen Kaarlo , Ma Yibo , Rissanen Marja , Nygren Nicole , Guizani Chamseddine , Hummel Michael , Sixta Herbert
Published: October 2021

The production of cellulose-based textile fibers with high toughness is vital for extending the longevity and thus developing a sustainable textile industry by reducing the global burden of microplastics. This study presented strategies to improve fiber toughness by tuning spinneret geometries. Experimental studies were conducted by spinning with different spinneret geometries and measuring the mechanical and structural properties of the spun fibers. In addition, numerical simulation tools were used to better understand the effects of spinneret geometry. The altering parameters of the spinneret geometries were the capillary diameters D, the angle of the entry cone into the spinning capillary, and the ratio of capillary length to diameter L/D. The highest fiber toughness could be achieved at a capillary aspect ratio of 1 to 2. The obtained maximum fiber toughness was 93 MPa with a tensile strength of 60 cN/tex and a concomitant elongation of 16.5%. For these fiber properties, a 13 wt% solution of a high-purity pulp with higher viscosity in [DBNH][OAc] was spun into a 1.3 dtex fiber using a D100 spinneret with a capillary of 1:1 length/diameter and an entrance angle of 8°. It was noticeable that the microvoid orientations decreased almost linearly with increasing toughness of the fibers. The morphologies of the fibers were similar regardless of the spinneret geometries and the raw materials used in the spinning process. In summary, by modulating the spinneret geometries, Ioncell fibers obtained high toughness that have the potential to replace synthetic fibers.
Should gains from criminal knowledge be forfeited?
Authors: Mamak Kamil , Barczak-Oplustil Agnieszka , Kwiatkowski Daniel , Małecki Mikołaj , Zając Dominik
Published: October 2021

Nobody should profit from crime; this fundamental moral principle is uncontroversial. At the level of public declaration, few people are likely to disagree with this statement; however, controversies arise when the implementation of this principle is under discussion. Numerous provisions exist that aim to strip criminals of the proceeds from their crimes, but not all aspects of this issue are immediately apparent. For example, a significant question is how to treat profits that a criminal makes from activities including recounting stories about their criminal activities, publishing books describing their actions, or creating YouTube videos presenting details about their crimes. Such profits are either treated as legitimate or are targeted by complicated legal methods of deprivation. The view presented in this paper could facilitate the ability to strip criminals from these forms of profit. This article argues that revenue accruing from knowledge gained from association with crime should be treated as indirect proceeds of crime and, as such, should be forfeited.
Flow cytometric approach to evaluate the impact of hydro-technical concrete compounds’ release to the freshwater microbiome
Authors: Wojtasik Barbara , Zbawicka Małgorzata , Grabarczyk Lucyna , Juzwa Wojciech
Published: October 2021

The aim of this research was to test the potential of applying a flow cytometric procedure to evaluate the impact of concrete compounds’ release to the freshwater microbiome. Cells from the collected samples were stained with a fluorogenic redox indicator dye that measures the redox potential of microbial cells. This novel approach was combined with the assessment of microorganisms’ penetration into the internal structures of concrete using the Rose Bengal sodium salt staining. Rose Bengal staining revealed an intense fouling of the upper and side walls of the concrete cubes and also indicated the penetration of microorganisms inside the concrete as observed for the cubes’ cross-sections. Flow cytometric cellular redox potential measurement revealed high percentages of active cells within the concrete’s porous structures and in non-exposed water (32.7% and 30.2% of active cells) versus samples from exposed water and concrete’s outer surfaces (6.8%, 6.1%, and 3.3% of active cells). The results demonstrated a detrimental impact of hydro-technical concrete on the vitality of microbial cells within the freshwater environment. Tested protocol by analyzing the physiology of microbial cells improved the functional description of complex communities to evaluate the fate of contaminants present in the concrete-based hydro-technical infrastructure.
Positive experiences of healthcare professionals with a mainstreaming approach of germline genetic testing for women with ovarian cancer
Authors: Bokkers Kyra , Zweemer Ronald P. , Koudijs Marco J. , Stehouwer Sanne , Velthuizen Mary E. , Bleiker Eveline M. A. , Ausems Margreet G. E. M.
Published: October 2021

According to current guidelines, all women with epithelial ovarian cancer are eligible for genetic testing for BRCA germline pathogenic variants. Unfortunately, not all affected women are tested. We evaluated the acceptability and feasibility for non-genetic healthcare professionals to incorporate germline genetic testing into their daily practice. We developed and implemented a mainstreaming pathway, including a training module, in collaboration with various healthcare professionals and patient organizations. Healthcare professionals from 4 different hospitals were invited to participate. After completing the training module, gynecologic oncologists, gynecologists with a subspecialty training in oncology, and nurse specialists discussed and ordered genetic testing themselves. They received a questionnaire before completing the training module and 6 months after working according to the new pathway. We assessed healthcare professionals’ attitudes, perceived knowledge, and self-efficacy, along with the feasibility of this new mainstream workflow in clinical practice, and evaluated the use and content of the training module. The participation rate for completing the training module was 90% (N = 19/21). At baseline and after 6 months, healthcare professionals had a positive attitude, high perceived knowledge and high self-efficacy toward discussing and ordering genetic testing. Knowledge had increased significantly after 6 months. The training module was rated with an average of 8.1 out of 10 and was considered useful. The majority of healthcare professionals (9/15) was able to discuss a genetic test in five to 10 min. After completion of a training module, non-genetic healthcare professionals feel motivated and competent to discuss and order genetic testing themselves.
Assessment of genetic diversity within eucheumatoid cultivars in east Sabah, Malaysia
Authors: Tan Pui-Ling , Poong Sze-Wan , Tan Ji , Brakel Janina , Gachon Claire , Brodie Juliet , Sade Ahemad , Lim Phaik-Eem
Published: October 2021

Studies have shown that cultivars of the carrageenophytes Kappaphycus and Eucheuma are clones of a limited number of strains originally domesticated from wild populations. For the development and selection of new cultivars, it is important that a comprehensive record of available variants exists. This study was conducted to provide up-to-date analysis and compilation of the current state of cultivars as the last list of cultivars was compiled nearly a decade ago. The present study analyzed the cox2–3 spacer and cox1 (1356 bp) genetic diversity of cultivars collected from 2019 to 2020 from the east coast of Sabah where the seaweed farms are concentrated. These data were compared with cultivars reported from 2010 to 2012 to assess changes, if any, to the gene pool of farmed eucheumatoid in Malaysia. Kappaphycus alvarezii, K. striatus, and K. malesianus are currently cultivated while Eucheuma denticulatum is no longer an important cultivar compared to a decade ago, probably due to its lower price. Analysis of the cox2–3 spacer revealed a new haplotype, LBT10, and, by including published GenBank data, a further four previously unnamed haplotypes were recognized from Sabah. This study confirms that there is a limited gene pool within cultivars in Malaysia and suggests the need for new or genetically diverse cultivars which can adapt to a changing environment, to ensure a more sustainable carrageenan industry.
Fine roots stimulate nutrient release during early stages of leaf litter decomposition in a Central Amazon rainforest
Authors: Martins Nathielly P. , Fuchslueger Lucia , Fleischer Katrin , Andersen Kelly M. , Assis Rafael L. , Baccaro Fabricio B. , Camargo Plínio B. , Cordeiro Amanda L. , Grandis Adriana , Hartley Iain P. , Hofhansl Florian , Lugli Laynara F. , Lapola David M. , Menezes Juliane G. , Norby Richard J. , Rammig Anja , Rosa Jessica S. , Schaap Karst J. , Takeshi Bruno , Valverde-Barrantes Oscar J. , Quesada Carlos A.
Published: October 2021

Purpose

Large parts of the Amazon rainforest grow on weathered soils depleted in phosphorus and rock-derived cations. We tested the hypothesis that in this ecosystem, fine roots stimulate decomposition and nutrient release from leaf litter biochemically by releasing enzymes, and by exuding labile carbon stimulating microbial decomposers.

Methods

We monitored leaf litter decomposition in a Central Amazon tropical rainforest, where fine roots were either present or excluded, over 188 days and added labile carbon substrates (glucose and citric acid) in a fully factorial design. We tracked litter mass loss, remaining carbon, nitrogen, phosphorus and cation concentrations, extracellular enzyme activity and microbial carbon and nutrient concentrations.

Results

Fine root presence did not affect litter mass loss but significantly increased the loss of phosphorus and cations from leaf litter. In the presence of fine roots, acid phosphatase activity was 43.2% higher, while neither microbial stoichiometry, nor extracellular enzyme activities targeting carbon- and nitrogen-containing compounds changed. Glucose additions increased phosphorus loss from litter when fine roots were present, and enhanced phosphatase activity in root exclusions. Citric acid additions reduced litter mass loss, microbial biomass nitrogen and phosphorus, regardless of fine root presence or exclusion.

Conclusions

We conclude that plant roots release significant amounts of acid phosphatases into the litter layer and mobilize phosphorus without affecting litter mass loss. Our results further indicate that added labile carbon inputs (i.e. glucose) can stimulate acid phosphatase production by microbial decomposers, highlighting the potential importance of plant-microbial feedbacks in tropical forest ecosystems.
Gemeinnützigkeit, soziale Verantwortung und wirtschaftlicher Erfolg
Authors: Lochner Barbara , Altmann Jörg
Published: October 2021

Der Beitrag geht der Frage nach, inwiefern sich gemeinnützige Organisationen als wirtschaftliche Akteure positionieren (können) und welche Konsequenzen sich daraus für das Management ergeben.
Give it Another Try: What are the Effects of a Job Creation Scheme Especially Designed for Hard-to-Place Workers?
Authors: Brändle Tobias , Fervers Lukas
Published: October 2021

Previous evaluations of job creation schemes (JCS) reveal mostly negative employment effects, mainly due to inherent lock-in effects. In this paper, we assess the impact of an innovative JCS that employs a pre-selection mechanism to target programme participation on unemployed job seekers with very low integration chances, hereby reducing possible lock-in effects. Relying on high-quality administrative as well as survey data, we conduct regression-adjusted matching analyses to estimate the programme effect on integration into regular employment. Our results show that the programme did not succeed to foster labour market integration, but still entails remarkably negative employment effects in the first years after participation. We argue that this results from a principal-agent problem at the last step of the selection mechanism that may have led to cream-skimming rather than targeting on very hard to place workers. However, supplementary analyses reveal that negative effects can be avoided for subgroups with very poor employment chances in case of non-participation. These results are robust to the use of different matching estimators and definitions of non-participation. The inclusion of usually unobservable survey variables as well as placebo tests based on past employment outcomes refute concerns about endogenous selection. From a policy-perspective, these findings imply that targeting JCS on workers with very low integration chances is a key factor to avoid negative employment effects found in previous evaluations. At the methodological level, our analyses add to recent literature that assesses the credibility of non-experimental evaluations based on high-quality administrative data.
Karst Geoheritage of Tara National Park (Serbia) and Its Geotouristic Potential
Authors: Telbisz Tamás , Ćalić Jelena , Kovačević-Majkić Jelena , Milanović Ranko , Brankov Jovana , Micić Jasna
Published: October 2021

By the example of Tara National Park (NP), we present how the geoheritage can and should be presented in a NP where the primary role is played by biology. Tara NP has a rich geoheritage, especially its karst phenomena, which include gorges (e.g. the 1000-m-deep Drina Gorge), plateaus with dolines, dry valleys, and uvalas as well as springs and travertines. In addition, ophiolites also enrich the geoheritage; hence, the area has a high geodiversity. Large reservoirs of the territory provide an opportunity to study the anthropogenic impact on hydrology and geomorphology. After presenting the geoheritage elements of the area, we examine the views and knowledge of local people and visitors about karst and geotourism with the help of a questionnaire survey. The results show that local residents support the further development of tourism, but geotourism is a rather new concept for them. On the contrary, tourists are more familiar with geotourism. Among the development perspectives, tourists support those that involve only minor environmental changes, that is in agreement with NP policy. Finally, we formulate some suggestions about geotourism development in the area. First, we outline some plans for new geo-educational trails and viewpoints. Second, we highlight the possibility to increase the geo-content of some already existing programs (e.g. boat tours). Third, we emphasize that geotourism of Tara should be connected to neighbouring areas. A new geopark is already under planning, which would include the area of Tara NP as well.
Two extensions of consumer surplus
Authors: Corchón Luis C. , Torregrosa Ramón J.
Published: October 2021

We study consumer surplus in a single market when (a) there is a lower bound in the consumption of the outside good and (b) the weights in the social welfare function given to consumers and firms are different. We assume quasilinear utility. When the lower bound constraint on the consumption of the outside good is binding, income effects arise in demand. In some cases, Cournot equilibrium output is below equilibrium output without this constraint because the constraint makes demand less elastic. When the weights given to consumers and firms are not identical, social welfare is not necessarily concave and profits might be negative at the unrestricted optimum. We characterize social welfare optimum with a bound on maximum losses in a class of utility functions. We offer a formula to find the percentage of welfare losses due to oligopoly in this case.
Floating photovoltaic system for Indian artificial reservoirs—an effective approach to reduce evaporation and carbon emission
Authors: Ravichandran N. , Ravichandran N. , Panneerselvam B.
Published: October 2021

Floating photovoltaic system for reservoirs is a recent innovative technology that is highly advantageous in reducing evaporation while generating solar power. In addition, the integration of floating photovoltaic systems with the existing hydroelectric power plants will increase renewable power production. The present study aims to assess the electrical performance of floating photovoltaic systems in major reservoirs with existing hydroelectric power plants in India. The reservoirs with large water surface area were selected for the study, and a model floating photovoltaic system with a 5-MW capacity was designed for the selected reservoirs. The numerical analysis showed that installing floating photovoltaic systems will result in an annual energy yield of 160 GWh. Further, the systems also save 1.40 million cubic meters of water per day and also help in generating additional energy of 514.80 MWh/day from the saved water through its integration with hydroelectric power plants. A single-axis tracking mechanism to the floating photovoltaic systems will increase the annual energy generation by 11%. The detailed cost analysis and carbon emission analysis were also carried out. The results indicate that the tracking mechanisms increase the total installation cost of the systems. The annual carbon emission reduction from the floating photovoltaic systems accounts for about 3.30 million tons of CO2. The obtained results highlight the suitability of this innovative technology for installation in Indian reservoirs and its effectiveness in reducing evaporation and carbon emission.

Graphic abstract
Trustworthy AI and Corporate Governance: The EU’s Ethics Guidelines for Trustworthy Artificial Intelligence from a Company Law Perspective
Authors: Hickman Eleanore , Petrin Martin
Published: October 2021

AI will change many aspects of the world we live in, including the way corporations are governed. Many efficiencies and improvements are likely, but there are also potential dangers, including the threat of harmful impacts on third parties, discriminatory practices, data and privacy breaches, fraudulent practices and even ‘rogue AI’. To address these dangers, the EU published ‘The Expert Group’s Policy and Investment Recommendations for Trustworthy AI’ (the Guidelines). The Guidelines produce seven principles from its four foundational pillars of respect for human autonomy, prevention of harm, fairness, and explicability. If implemented by business, the impact on corporate governance will be substantial. Fundamental questions at the intersection of ethics and law are considered, but because the Guidelines only address the former without (much) reference to the latter, their practical application is challenging for business. Further, while they promote many positive corporate governance principles—including a stakeholder-oriented (‘human-centric’) corporate purpose and diversity, non-discrimination, and fairness—it is clear that their general nature leaves many questions and concerns unanswered. In this paper we examine the potential significance and impact of the Guidelines on selected corporate law and governance issues. We conclude that more specificity is needed in relation to how the principles therein will harmonise with company law rules and governance principles. However, despite their imperfections, until harder legislative instruments emerge, the Guidelines provide a useful starting point for directing businesses towards establishing trustworthy AI.
Die Überdeckung der Next Generation EU-Schulden im neuen EU-Eigenmittelbeschluss: Ausmaß und Haftungskonsequenzen
Authors: Heinemann Friedrich
Published: October 2021

Diese Analyse befasst sich mit der Absicherung der EU-Schulden, die gemäß dem neuen EU-Eigenmittelbeschluss zur Finanzierung des EU-Corona-Wiederaufbauplans Next Generation EU (NGEU) aufgenommen werden sollen. Diese Absicherung erfolgt unter anderem durch eine gesonderte Eigenmittel-Nachschussverpflichtung der EU-Mitgliedstaaten im Umfang von 0,6 % des nationalen Bruttonationaleinkommens (BNE). Simulationen zeigen, dass diese 0,6 % des BNE eine sehr starke Überdeckung darstellen, weil damit ein Tilgungspotenzial durch den EU-Haushalt geschaffen wird, welches den durch NGEU verursachten Rückzahlungsbedarf auch unter sehr vorsichtigen Annahmen zum BNE-Wachstum um ein Vielfaches übersteigt. Die Studie beleuchtet darüber hinaus die Signale, Anreize und Haftungskonsequenzen, die sich aus dieser weitreichenden Überdeckung der Corona-Schulden ergeben. Die bis zum Jahr 2058 reichende umfangreiche Tilgungsfähigkeit des EU-Haushalts geht weit über den eigentlichen NGEU-Bedarf hinaus und kann als Signal verstanden werden, dass in den kommenden Jahrzehnten bei Bedarf rasch neue EU-Verschuldungsfenster geschaffen werden können. Der Beitrag beleuchtet außerdem eine weitere Konsequenz der Überdeckung in Bezug auf die maximal denkbare Haftung des Bundeshaushalts für die NGEU-Schulden. Die Berechnungen zeigen, dass diese Haftung faktisch nicht wie beim Europäischen Stabilitätsmechanismus auf eine Teilschuld des Fonds begrenzt ist.
Kynurenine pathway in kidney diseases
Authors: Zakrocka Izabela , Załuska Wojciech
Published: October 2021

Kidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis is uncertain. Moreover, data on diagnostic and prognostic markers in kidney diseases are lacking. The kynurenine (KYN) pathway is one of the routes of tryptophan (Trp) degradation, with biologically active substances presenting ambiguous properties. The KYN pathway is known to be highly dependent on immunological system activity. As the kidneys are one of the main organs involved in the formation, degradation and excretion of Trp end products, pathologies involving the kidneys result in KYN pathway activity disturbances. This review aims to summarize changes in the KYN pathway observed in the most common kidney disease, chronic kidney disease (CKD), with a special focus on diabetic kidney disease, acute kidney injury (AKI), glomerulonephritis and kidney graft function monitoring. Additionally, the importance of KYN pathway activity in kidney cancer pathogenesis is discussed, as are available pharmacological agents affecting KYN pathway activity in the kidney. Despite limited clinical data, the KYN pathway appears to be a promising target in the diagnosis and prognosis of kidney diseases. Modulation of KYN pathway activity by pharmacological agents should be considered in the treatment of kidney diseases.
Utilitarianism without Moral Aggregation
Authors: Gustafsson Johan E.
Published: October 2021

Is an outcome where many people are saved and one person dies better than an outcome where the one is saved and the many die? According to the standard utilitarian justification, the former is better because it has a greater sum total of well-being. This justification involves a controversial form of moral aggregation, because it is based on a comparison between aggregates of different people’s well-being. Still, an alternative justification—the Argument for Best Outcomes—does not involve moral aggregation. I extend the Argument for Best Outcomes to show that any utilitarian evaluation can be justified without moral aggregation.
Associated factors to the consumption of ultra-processed foods and its relation with dietary sources in Portugal
Authors: Magalhães Vânia , Severo Milton , Correia Daniela , Torres Duarte , Costa de Miranda Renata , Rauber Fernanda , Levy Renata , Rodrigues Sara , Lopes Carla
Published: October 2021

Ultra-processed foods (UPFs) are common worldwide and associated with poorer health outcomes. This work aimed to explore the UPF consumption associated factors and its main dietary sources, by sex, in Portugal. Participants from the National Food, Nutrition and Physical Activity Survey (IAN-AF) 2015–2016, aged 3–84 years, were included (n 5005). Dietary intake was assessed through two 1-day food diaries/24 h recalls. UPFs were identified using the NOVA classification. Associations were evaluated through linear regression models. Median UPF consumption was 257 g/d (10⋅6 % of total quantity; 23⋅8 % of total energy). Adolescents were those with higher consumption (490 g/d). Compared to adults, younger ages were positively associated with UPF consumption (e.g. adolescents (

$\hat{\beta }$

-females: 192, 95 % confidence interval (CI): 135, 249;

$\hat{\beta }$

-males: 327, 95 % CI: 277, 377)). A lower educational level was associated with lower UPF consumption (

$\hat{\beta }$

-females: −63; 95 % CI: −91, −34;

$\hat{\beta }$

-males: −68; 95 % CI: −124, −12). Also, a lower UPF consumption was observed in married males/couples compared to singles (

$\hat{\beta }$

: −48, 95 % CI: −96, −1). Furthermore, female current/former smokers were associated with a higher UPF consumption v. never smokers (

$\hat{\beta }$

: 79, 95 % CI: 41, 118;

$\hat{\beta }$

: 42, 95 % CI: 8, 75, respectively). Main UPF sources were yoghurts, soft drinks and cold meats/sausages differing strongly by sex, age and education level. Yoghurts containing additives were the main contributors to the UPF consumption in children and adult females from all education (~20 %). Soft drinks were leaders in adolescents (females: 26⋅0 %; males: 31⋅6 %) and young male adults (24⋅4 %). Cold meats/sausages stood out among low-educated males (20⋅5 %). Males, younger age groups, higher education, children with less-educated parents, married/couple males and smoking females were positively associated with UPF consumption.
THE LATE HELLENISTIC WINE PRESS EXCAVATIONS FROM KNOSSOS: THE EARLY IRON AGE, HELLENISTIC AND EARLY ROMAN CONTEXTS
Authors: Trainor Conor P.
Published: October 2021

The remains of an exceptionally well-preserved Hellenistic wine press were uncovered during a rescue excavation at Knossos in 1977. The architecture, stratigraphy and faunal remains from this campaign were published inBSA89 (1994) by J. Carington Smith (the excavator) and S. Wall. The artefact assemblages from this excavation, however, have remained unstudied and unpublished until now. The current article presents the artefact assemblages from the wine press excavation and considers them within their urban context at Knossos. The key findings from this excavation relate to the Late Hellenistic wine press and its associated material, which enables us to consider both the ancient winemaking process at Knossos and the economic topography of the city in the decades around the Roman conquest of the island in 67bc. In addition to the Late Hellenistic phase, material of Minoan, Early Iron Age–Early Archaic, earlier Hellenistic and Early Roman dates is also presented and discussed.
An innovative approach to the assessment of mood disturbances in patients with acute coronary syndrome
Authors: Gostoli Sara , Buzzichelli Sara , Guidi Jenny , Sirri Laura , Marzola Enrica , Roncuzzi Renzo , Abbate-Daga Giovanni , Fava Giovanni A. , Rafanelli Chiara
Published: October 2021

Background

The clinical value of the identification of mood disorders in patients with acute coronary syndrome (ACS) is well established. However, assessment based on DSM criteria presents some limitations. This study aimed to provide an innovative strategy for evaluating the spectrum of mood disturbances in ACS.

Methods

A total of 288 patients with a first episode of ACS underwent interviews based on DSM-IV-TR criteria (major depressive disorder, minor depression, and dysthymia), Diagnostic Criteria for Psychosomatic Research-DCPR (demoralization and type A behavior), and the Clinical Interview for Depression-CID. Additional self-report inventories (psychological well-being and distress) were administered. A total of 100 consecutive patients who satisfied criteria for DSM-IV-TR depression or DCPR demoralization were enrolled in a randomized controlled trial on a sequential combination of cognitive-behavioral and well-being therapy (CBT/WBT) vs clinical management (CM) and reassessed up to 30-month post-intervention.

Results

A total of 29.9% of patients showed a DSM-IV-TR depressive syndrome. Inclusion of demoralization and type A identified psychological distress in 58% of the sample. According to CID, reactivity to social environment, fatigue, depressed mood, and somatic anxiety were the most common symptoms. Somatic symptoms were significantly associated with DSM-IV-TR depression (fatigue and changes of appetite), whereas environmental reactivity with demoralization. Both depression and demoralization were associated with higher distress and lower well-being. Unlike CM, CBT/WBT was significantly associated with decrease of guilt, pessimism, fatigue, and early insomnia (CID).

Conclusions

The findings indicate that standard psychiatric approach identifies only a narrow part of mood disturbances affecting ACS patients. A more articulated assessment unravels specific clinical configurations that may entail prognostic and therapeutic implications.
A wideband and directive metasurface FPC antenna with toroidal metal structure loading
Authors: Dawar Parul , Abdalla Mahmoud A.
Published: October 2021

In this paper, a novel metasurface-based Fabry−Perot cavity antenna loaded with toroidal metal structures is presented. The antenna is compact, wideband, and has high directivity and a high front-to-back ratio. The idea of the antenna is based on loading a microstrip narrow band patch antenna resonating at 4.5 GHz by a single layer metasurface superstrate and with a toroidal metal structure. The metasurface superstrate comprises a periodic array of square patch cells. Compared to conventional microstrip antenna, the front to back lobe ratio is increased from 7 to 20 dB and the directivity is increased by 7 dB. Also, the antenna impedance bandwidth is 34% which is increased four times. This is the first-ever antenna with enhanced bandwidth and directivity using a single layer of metasurface and that too made up of periodic cell array and has application as an energy harvester.
Biases Beyond the Mean in CMIP6 Extreme Precipitation: A Global Investigation
Authors: Abdelmoaty Hebatallah Mohamed , Papalexiou Simon Michael , Rajulapati Chandra Rupa , AghaKouchak Amir
Published: October 2021

Climate models are crucial for assessing climate variability and change. A reliable model for future climate should reasonably simulate the historical climate. Here, we assess the performance of CMIP6 models in reproducing statistical properties of observed annual maxima of daily precipitation. We go beyond the commonly used methods and assess CMIP6 simulations on three scales by performing: (a) univariate comparison based on L‐moments and relative difference measures; (b) bivariate comparison using Kernel densities of mean and L‐variation, and of L‐skewness and L‐kurtosis, and (c) comparison of the entire distribution function using the Generalized Extreme Value () distribution coupled with a novel application of the Anderson‐Darling Goodness‐of‐fit test. The results reveal that the statistical shape properties (related to the frequency and magnitude of extremes) of CMIP6 simulations match well with the observational datasets. The simulated mean and variation differ among the models with 70% of simulations having a difference within10% from the observations. Biases are observed in the bivariate investigation of mean and variation. Several models perform well with the HadGEM3‐GC31‐MM model performing well in all three scales when compared to the ground‐based Global Precipitation Climatology Centre data. Finally, the study highlights biases of CMIP6 models in simulating extreme precipitation in the Arctic, Tropics, arid and semi‐arid regions.
Dynamics of Interannual Eddy Kinetic Energy Modulations in a Western Boundary Current
Authors: Li Junde , Roughan Moninya , Kerry Colette
Published: October 2021

Among Western Boundary Currents, the East Australian Current (EAC) has a more energetic eddy field relative to its mean flow, however, the relationship between upstream transport and downstream eddy kinetic energy (EKE) is still unclear. We investigate the modulation of downstream EKE in the EAC's typical separation region (Tasman EKE Box) (33.S–36.S) based on a long‐term (22‐year), high‐resolution (2.5–6 km) model simulation and satellite altimeter observations from 1994 to 2016. Our results show that the poleward EAC transport at S leads the EKE in the Tasman EKE Box by 93–118 days. Barotropic instabilities are the primary source of EKE, and they control EKE variability in the EAC system. Anticyclonic eddies shed from the EAC dominate from S–S during high‐EKE periods, but in low‐EKE periods anticyclonic eddies penetrate even further south by .
Regionalization of the Red Sea Based on Phytoplankton Phenology: A Satellite Analysis
Authors: Kheireddine Malika , Mayot N. , Ouhssain M. , Jones B. H.
Published: October 2021

The current average state of Red Sea phytoplankton phenology needs to be resolved in order to study future variations that could be induced by climate change. Moreover, a regionalization of the Red Sea could help to identify areas of interest and guide in situ sampling strategies. Here, a clustering method used 21 years of satellite surface chlorophyll‐a concentration observations to characterize similar regions of the Red Sea. Four relevant phytoplankton spatiotemporal patterns (i.e., bio‐regions) were found and linked to biophysical interactions occurring in their respective areas. Two of them, located in the northern part the Red Sea, were characterized by a distinct winter‐time phytoplankton bloom induced by mixing events or associated with a convergence zone. The other two, located in the southern regions, were characterized by phytoplankton blooms in summer and winter which might be under the influence of water advected into the Red Sea from the Gulf of Aden in response to the seasonal monsoon winds. Some observed inter‐annual variabilities in these bio‐regions suggested that physical mechanisms could be highly variable in response to variations in air‐sea heat fluxes and ENSO phases in the northern and southern half of the Red Sea, respectively. This study reveals the importance of sustaining in situ measurements in the Red Sea to build a full understanding about the physical processes that contribute to phytoplankton production in this basin.
Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium
Authors: Javaheripour Nooshin , Li Meng , Chand Tara , Krug Axel , Kircher Tilo , Dannlowski Udo , Nenadić Igor , Hamilton J. Paul , Sacchet Matthew D. , Gotlib Ian H. , Walter Henrik , Frodl Thomas , Grimm Simone , Harrison Ben J. , Wolf Christian Robert , Olbrich Sebastian , van Wingen Guido , Pezawas Lukas , Parker Gordon , Hyett Matthew P. , Sämann Philipp G. , Hahn Tim , Steinsträter Olaf , Jansen Andreas , Yuksel Dilara , Kämpe Robin , Davey Christopher G. , Meyer Bernhard , Bartova Lucie , Croy Ilona , Walter Martin , Wagner Gerd
Published: October 2021

Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectivity (FC) at resting-state functional MRI, that may help identifying neural markers of MDD and provide further efficient diagnosis and monitor treatment outcomes. The main aim of the present study is to investigate, in an unbiased way, functional alterations in patients with MDD using a large multi-center dataset from the PsyMRI consortium including 1546 participants from 19 centers (www.psymri.com). After applying strict exclusion criteria, the final sample consisted of 606 MDD patients (age: 35.8 ± 11.9 y.o.; females: 60.7%) and 476 healthy participants (age: 33.3 ± 11.0 y.o.; females: 56.7%). We found significant relative hypoconnectivity within somatosensory motor (SMN), salience (SN) networks and between SMN, SN, dorsal attention (DAN), and visual (VN) networks in MDD patients. No significant differences were detected within the default mode (DMN) and frontoparietal networks (FPN). In addition, alterations in network organization were observed in terms of significantly lower network segregation of SMN in MDD patients. Although medicated patients showed significantly lower FC within DMN, FPN, and SN than unmedicated patients, there were no differences between medicated and unmedicated groups in terms of network organization in SMN. We conclude that the network organization of cortical networks, involved in processing of sensory information, might be a more stable neuroimaging marker for MDD than previously assumed alterations in higher-order neural networks like DMN and FPN.