bluuebunny/crossref_metadata_2025 huggingface dataset:
Sokak Sütlerinde Gizli Tehlike: Antibiyotik Kalıntısı
Authors: Mortaş Hande , Navruz Varlı Semra , Bilici Saniye
Published: May 2022

Amaç: Süt hayvanlarının sağlığını korumak amacıyla kullanılan antibiyotiklerin sütlerde bıraktığı antibiyotik kalıntıları insan sağlığını önemli derecede tehdit etmektedir. Ayrıca sütteki antibiyotik kalıntılarının ısıl işlemlerle nötralize edilemediği de bildirilmektedir. Bu nedenlerle denetimsiz satılan çiğ sütlerin antibiyotik kalıntısı açısından değerlendirilmesi son derece önemlidir. Bu çalışmada, Ankara ilinde sokakta satılan çiğ sütlerin içerdiği antibiyotik kalıntılarının araştırılması amaçlanmıştır.

Gereç ve Yöntem: Bu çalışmanın örneklemini oluşturan sokak sütlerinin Ankara ilini temsil etmesi için Ankara’nın en yoğun nüfusa sahip 9 ilçesinden nüfus yoğunluklarına göre belirlenen sayılarda toplam 60 adet sokak sütü numunesi araştırmacılar tarafından toplanmıştır. Alınan sokak sütleri Idexx Snap ST Plus DUO kullanılarak antibiyotik kalıntıları açısından araştırılmıştır.

Bulgular: Çalışmada alınan sokak sütü numunelerinin toplam %30’unda antibiyotik kalıntı miktarlarının yönetmelikte belirlenen limitleri aştığı tespit edilmiştir. Bunlardan %28.3’ünün (n=17) beta-laktam kalıntı içeriğinin, %1.7’sinin (n=1) ise tetrasiklin kalıntı içeriğinin mevzuatta belirlenen limitlerin üzerinde olduğu saptanmıştır.

Sonuç: Ankara’da satışa sunulan sokak sütlerinde tespit edilen antibiyotik kalıntılarının mevzuata uygun olmaması, antibiyotik kalıntı maruziyetinin neden olabileceği sağlık risklerinin yanı sıra antibiyotik direnci gelişimine de katkı sağlayabileceği için endişe vericidir. Son yıllarda doğal olduğu düşüncesi ile artan çiğ süt tüketim eğilimi de göz önünde bulundurulduğunda denetimsiz olarak satılan sokak sütlerinin satışı ile ilgili yaptırım ve denetimlerin arttırılması ve bu konuda tüketicilerin bilinçlendirilmesi önemlidir.
Dijital Sağlık: Beslenme ve Diyetetik Bilim Dalında Yaklaşım
Authors: Pekcan Ayla Gülden
Published: May 2022

Dijital sağlık bakımının eSağlık, teletıp, teleizleme ve dijital terapötik uygulamaları kapsadığı rapor edilmektedir. Dijital sağlık, telesağlık ve eSağlık birbiri yerine geçen terimler olarak ele alınmakta, sağlık bakım hizmetlerini telekomünikasyon veya dijital teknoloji ile destekleyerek sağlık bakım hizmetlerini desteklemek veya geliştirmek olarak tanımlanmaktadır. eSağlık’ın sağlık hizmetlerinin her basamağının (önleme, tanı, karar verme, tedavi/müdahale ve izleme) bir parçası olabileceği belirtilmektedir. Teletıp sağlık hizmetlerinin sağlık profesyonelleri tarafından telekomünikasyon platformlarının kullanılarak uzaktan sağlanmasıdır. Sağlık bakım hizmetleri, örneğin hastanın değerlendirilmesi, tanı konulması veya tedavisi süreçlerini içermektedir. Bu uygulamanın etik ve yasal boyutları da dikkate alınmalıdır. Teleizleme ise dijital teknolojiyi kullanarak sık sık veya düzenli olarak bireyin/hastanın yaşamsal belirtilerini veya belirtilerinin izlenmesini kapsamaktadır. Dijital tedavinin de tıbbi kılavuzlara ve iyi uygulamalara dayalı olarak algoritmaları kapsamasının gerekliliği vurgulanmaktadır. Dijital sağlık tüm ülkelerde çoklu bulaşıcı olamayan kronik hastalıkları olan yaşlı popülasyonunda sağlık hizmetlerinin sunulmasına destek sağlamaktadır. Özellikle COVID-19 pandemisi sürecinde sağlık hizmetlerine erişim ve sunum sorun oluşturmuştur. Dijital sağlık teknolojileri bireyselleştirilmiş (kişiselleştirilmiş) beslenme hizmetlerinin sunulmasına kişisel verilerin ve teknoloji destekli sunum yöntemlerinin kullanılması ile destek olabilmektedir. Alışılmış veya geleneksel diyetetik hizmetlerinin tüm ülkelerde dijital değişikliklere uğradığı, duyarlı ve yüksek kalite beslenme bakımının dijital değişiklikler ile desteklendiği de görülmektedir. Diyetisyenlerin de bu teknolojik gelişmelerle yan yana durması, bu dönüşümde lider olması, sadece uygulayıcı olmaması bir zorunluluktur. Böylece diyetisyenler günümüzde ve aynı zamanda da gelecekte kanıta dayalı beslenme uygulamalarında başarılı olabilir ve etkilerini artırabilirler.
AL MUBARAK SUDIANG ISLAMIC BOARDING SCHOOL STUDENTS EMPOWERED IN THE CULTIVATION AND UTILIZATION OF MEDICINAL PLANTS
Authors: Dewi Ratnasari , Kamaruddin Mudyawati , Rafidah Rafidah , Stevani Hendra , Sukmawaty Muli , Siswanty Ivonne
Published: May 2022

Based on interviews with a partner, the following community partner issues were lack of medicinal plants gardens around the Al Mubarak Sudiang Islamic boarding school, lack of knowledge and introduction to the types of plants with medicinal properties, and lack of knowledge about the health benefits of medicinal plants. Using traditional medicinal plants is the community's active participation in solving health problems. The community service partner were students in Al Mubarak boarding school. The solution to overcome the partner's problems was empowerment with a participatory learning approach emphasizing learning through consultation, training, coaching, and demonstration/simulation of medicinal plant cultivation and utilization. Then, the authors evaluated program implementation and sustainability before and after activities. The evaluation showed increased achievement levels in all success indicators. Thus, this community service had significant benefits for all participants. In conclusion, the empowerment of students in Al Mubarak Sudiang Islamic Boarding School can increase their knowledge in medicinal plants cultivation and utilization, skills in medicinal plants cultivation, and medicinal plants utilization. The local government should support and participate in the sustainability of this community service through small industries producing healthy drinks from medicinal plants.
Managing Sustainable Consumption: Shaping the Customer Journey with Focus on Sustainability in the Food Industry
Authors: Steinbiß Kristina , Fröhlich Elisabeth , Sander Julia
Published: May 2022

As consumer awareness surrounding impacts of the climate crisis continues to be a notable threat, businesses are searching for new models to make their sustainability profile even better. As a result, the implementation of a company’s sustainability vision following the SDGs has to be linked closely to the integration of customers into strategic action. One success factor is the management of customers over their entire life cycle. The Customer Journey serves as a model to systematise this approach, by designing touchpoints throughout the purchasing process in order to motivate consumers to act sustainably. Based on behaviour models, the authors develop recommendations for the food industry to design a sustainable Customer Journey that helps to reduce the percentage of consumers reporting positive attitudes to sustainable products while not exhibiting corresponding behaviour.
Analysis of the Twitter discourse on sustainability using natural language processing
Authors: Tóth Tímea Emese
Published: May 2022

This publication aims to map the environmental sustainability discourse on Twitter. This will be achieved through two commonly used methods of natural language processing; topic modelling, which is used to uncover hidden themes in the document collection, and sentiment analysis, which is used to detect the attitudes of the authors of the text towards a particular attitude. The exploration of communication can provide an opportunity to find a solution to a multifaceted problem in order to protect our common future.
ÖĞRENCİLER İÇİN ZOOM TÜKENMİŞLİK VE YORGUNLUK ÖLÇEĞİNİN TÜRKÇE UYARLAMASI: GEÇERLİK VE GÜVENİLİRLİK ÇALIŞMASI
Authors: ATEŞ Vildan , KANIK Leyla
Published: May 2022

Dünya Sağlık Örgütü tarafından 2020 yılında ilan edilen Kovid-19 salgını nedeniyle eğitim kurumlarında uzaktan eğitime zorunlu olarak geçiş yaşanmıştır. Bilgisayar ve ekran başında geçirilen süre literatürde Zoom yorgunluğu veya Zoom tükenmişliği olarak tanımlanan ve hızla artan bir soruna yol açmıştır. Bu çalışmanın amacı; Fauville, Luo, Queiroz, Bailenson ve Hancock (2021) tarafından geliştirilen “Zoom Tükenmişlik ve Yorgunluk (ZTY) Ölçeği”nin Türkçeye uyarlanmış halinin öğrencilerin Zoom tükenmişlik ve yorgunluğunu ölçmek için geçerli ve güvenilir bir araç olup olmadığıdır. Araştırmanın çalışma grubu Türkiye’deki devlet üniversitelerinde Bilgi ve Belge Yönetimi (BBY) bölümünde öğrenim gören 310 üniversite öğrencisidir. ZTY ölçeğinin yapı geçerliği açıklayıcı faktör analizi (AFA) ile ve ölçeğin faktör yapısı LISREL paket programı kullanılarak analiz edilmiştir. Yapı güvenirliği ve yakınsama geçerliği doğrulayıcı faktör analizi (DFA) ile gerçekleştirilmiştir. Analizler sonucu ölçekteki beş faktörün t değerleri, hata varyansları, standart katsayıları ve uyum indeksleri kontrol edilmiş ve ZTY ölçeğinin öğrencilerin Zoom tükenmişlik ve yorgunluğunu ölçmek için geçerli ve güvenilir bir araç olduğu görülmüştür. Ayrıca BBY bölümü öğrencilerinin orta seviyenin üzerinde Zoom tükenmişliği ve yorgunluğuna sahip oldukları tespit edilmiştir.
18. YÜZYIL DİVAN ŞAİRİ AHMED BÂ'İS VE DİVANÇESİ
Authors: KAYA YİĞİT Bilge
Published: May 2022

18. yüzyıl siyasi bakımdan Osmanlı Devletinin zayıfladığı, güç kaybettiği bir yüzyıl olmasına rağmen devlet adamlarının da destekleriyle pek çok şair yetişmiş divan edebiyatı geçmiş asırlardaki canlılığını devam ettirmiş; Osmanlı sahasında pek çok Divan şairi yetişmiştir; bunlardan kimisi birinci sınıf şair olup ünü doğudan batıya pek çok memlekette yayılmıştır. Bazı şairlerse birinci sınıf şairlerimize göre gölgede kalmış şiirleri üzerinde ayrıntılı araştırma yapılmamıştır. Bu çalışmada ünü pek duyulmamış şairlerimizden Kasapbaşızâde Ahmed Bâis Efendi'nin hayatı ve divanı incelenmiş ve yayına hazırlanmıştır. Ahmet Bâis Efendi hakkında 1953 yılında mezuniyet tezi hazırlanmıştır Çalışmamızda bu tezden de faydalanılarak divanın gözden geçirilmiş metni hazırlanarak incelemesi yapılmıştır.
Ahmet Bâ’is Efendi'nin hayatı hakkında yeterli bilgi yoktur. Elimizde tek nüsha halinde Divanı bulunmaktadır. Bâ’is 18. yüzyılda yaşamıştır Kasapbaşızade Ahmed Efendi ifadesinden anlaşıldığına göre kasaplık yapmış bir aileden gelmektedir. Bursa'nın Mihalıç/Karacabey ilçesinde doğmuş olup eğitimini İstanbul'da tamamlamıştır değişik medreselerde müderrislik yapmış olup kâtiplik görevini de yürütmüştür. 1800-1801 yılında vefat etmiş olup mezarı Kahramanmaraş’tadır.
Bâ’is Divançesi talik yazıyla müellif tarafından yazılmış tek nüshası İstanbul Üniversitesi Nâdir Eserler Kütüphanesi’nde bulunmaktadır. Bâ’is’in tek eseri olan divanındaki şiirlerini şekil ve muhteva bakımından değerlendirdiğimizde şairin divan şiirinin sebk-i Hindî dönemi öncesindeki belli kurallar ve mazmunların bulunduğu sebk-i Irâkî üslubuna uygun şiirler yazdığını söyleyebiliriz.
Vision of Mountain Warfare Development in the Slovenian Armed Forces
Authors: Polanec Bernard
Published: May 2022

In the article, we will first introduce mountain warfare and explain the individual concepts related to mountain warfare. Further on, we will focus on contemporary warfare, including mountain warfare, and the importance of mountain warfare in the future. We will conclude the first part of the article by presenting the current situation regarding mountain units in the Slovenian Armed Forces.

In the second part, we will present the challenges faced by the Slovenian Armed Forces in the field of mountain warfare, and, finally, present our vision for the development of the Slovenian Armed Forces and mountain warfare, including some solutions in response to the challenges presented in the article.
2005 yılı öncesi ve sonrası öğretmen öğrenci ve veli profillerine ilişkin öğretmen görüşlerinin belirlenmesi
Authors: ÜNSAL Serkan , ÇETİN Abdullah , YÜKSEK Faruk
Published: May 2022

Bu araştırmanın amacı, Millî Eğitim Bakanlığının 2005 yılında uygulamaya koyduğu yeni eğitim anlayışı ve öğretim programları referans alınarak sonraki süreçte öğrenci, veli ve öğretmen özelliklerinde meydana gelen değişimleri belirlemektir. Araştırma nitel araştırma desenlerinden olgubilim deseninde yürütülmüştür. Araştırmanın çalışma grubunu 2018-2019 öğretim yılında Türkiye’nin bir ilindeki devlet okullarında görev yapan 11 gönüllü Anadolu Lisesi öğretmeni oluşturmuştur. Amaçsal örnekleme yönteminden ölçüt örnekleme yönteminin kullanıldığı araştırmada, Millî Eğitim Bakanlığına bağlı ortaöğretim kurumunda 2005 yılı öncesinde öğretmenlik yapmak ve halen öğretmenlik yapıyor olmak ölçüt olarak alınmıştır. Araştırma verilerinin toplanmasında yarı yapılandırılmış görüşme formu kullanılmıştır. Verilerin analizinde içerik analizi tekniği benimsenmiştir. Araştırmanın sonucunda lise öğretmenlerine göre 2005 öncesi ve sonrası öğrenciler genellikle benzer özellikler gösterseler de, 2005 sonrası öğrencilerde saygısızlık, sorumsuzluk, kendini hayatın merkezinde görme, sınırları bilmeme, bencil davranma, değerlerden uzaklaşma, derslere ilgisiz olma gibi olumsuz davranışlar daha sık görünür olmuştur. Öğretmenler velilerin 2005 sonrasında; okulun işleyişine aşırı karıştıklarını, öğretmeni ve okulu sorguladıklarını, aşırı korumacı olduklarını, öğrencisiyle kendini yücelttiklerini, öğrencileriyle daha çok ilgilendiklerini , anlayışsız olduklarını belirtmişlerdir.. Ayrıca öğretmenler velilerin 2005’ten önce öğretmene daha fazla güven duydukları sonra ise bu güvenin giderek azaldığı belirtmişlerdir. 2005 öncesinde öğretmenlerin toplumda saygınlıklarının daha iyi olduğu, entelektüel yönlerinin kuvvetli olduğu, sabırlı ve çalışkan oldukları öğretmenler tarafından ifade edilmiştir. Ancak yine 2005’ten önce öğretmenlerin kalıpların dışına çıkamadıkları ve kendilerini yenilemedikleri araştırmanın diğer bir sonucudur. 2005 sonrasında öğretmenlerin saygınlıklarını ve otoritelerini kaybettikleri, yenilenen sistemler yorgunu oldukları, maddiyatı önceleyen özellik taşıdıkları öğretmenler tarafından belirtilmiştir.
Role and Recent Trend of Intraoperative Parathyroid Hormone Monitoring During Parathyroidectomy in Patients With Primary Hyperparathyroidism
Authors: Ahn Dongbin , Kwak Ji Hye
Published: May 2022

In the last few decades, the standard surgical treatment for primary hyperparathyroidism (PHPT) has shifted from bilateral neck exploration to focused/minimally invasive parathyroidectomy (FMIP). This shift was accelerated by the introduction of intraoperative parathyroid hormone (IOPTH) monitoring, which can provide intraoperative information regarding the localization and complete excision of the pathological parathyroid gland during FMIP. Since the first clinical application of the IOPTH assay in 1991, IOPTH monitoring has substantially improved to date to increase its performance and availability. In addition, the clinical applications of IOPTH changed with the needs of actual clinical practice, although the fundamental concept and technique remained unchanged. In this review, we discuss the role of IOPTH monitoring in the surgical management of PHPT based on the results of contemporary studies and summarized the major issues regarding IOPTH.
Um olhar para a avaliação matemática: passado, presente na pandemia e futuro pós-pandêmico
Authors: Ribeiro Dione Baptista , Kistemann Jr Marco Aurelio
Published: May 2022

O objetivo do artigo é resgatar o passado, descrever o presente e traçar algumas perspectivas futuras a partir dos olhares e das experiências de dois educadores matemáticos engajados na prática da avaliação da aprendizagem matemática com o viés da inclusão. São descritos cenários pré-pandemia, na pandemia e no início do pós-pandemia, buscando evidenciar a importância da avaliação que reduza as formas de exclusão social e escolar que ficaram evidentes no período da pandemia da Covid-19 no Brasil e no mundo. Infere-se que a avaliação matemática deve permear as práticas docentes numa nova realidade com salas de aula híbridas e com novas possibilidades de aprendizagem online e semipresencial, a partir do uso de novos instrumentos e tecnologias que auxiliem o professor e os estudantes.
Effect of body size on the long-term reproductive output of eastern Atlantic loggerhead turtles Caretta caretta
Authors: Martins S , Cardona L , Abella E , Silva E , Loureiro NS , Roast M , Marco A
Published: May 2022

We assessed the relationship between body size and several important life history parameters to understand the demographic significance of interpopulation variability in the body size of loggerhead turtlesCaretta carettanesting on Boa Vista Island (Cabo Verde). The adult growth rate (0.34 ± 0.60 cm yr-1), annual mortality rate (0.13, 95% CI: 0.12-0.15) and remigration interval (3.1 ± 1.2 yr) were independent of curved carapace length (minimum curved carapace length [CCLmin]). Conversely, the body condition index decreased significantly with female CCLmin. The clutch size, mean egg mass, mean hatchling straight carapace length and mean hatchling mass increased significantly with female CCLmin. However, there was no relationship between female size and hatching success. Randomization and bootstrapping were used to incorporate variability when calculating the average individual fecundity over 20 yr, a period that accumulated, on average, 94% of the adult mortality. The overall fecundity during this period increased with carapace length at first maturity (71 cm CCLmin: 815 eggs, 95% CI: 653-863; 80 cm CCLmin: 906 eggs, 95% CI: 822-959; 90 cm CCLmin: 1089 eggs, 95% CI: 926-1415). However, only 8% of the adult females nesting on Boa Vista Island are larger than 90 cm CCLmin, and they produce less than 12% of the total annual egg production. The scarcity of large females might result from a shortage of high-quality foraging grounds where females may reach first sexual maturity at a large carapace length and from the combined effect of a small carapace length at first sexual maturity, low adult somatic growth and high adult mortality.
Seasonal changes in facilitation between an ascidian and a kelp in Patagonia
Authors: Arcángel AE , Rodríguez EA , de la Barra P , Pereyra PJ , Narvarte M
Published: May 2022

Positive interactions between species may change in outcome over time and may differ for the two interacting species. We explored the seasonal patterns of facilitation between an ascidian (Styela clava) and a macroalga (Undaria pinnatifida) by following their association for a complete sporophytic phase. In addition, we investigated how the relationship affected the morphometric parameters of U. pinnatifida, and whether the association had a negative outcome for S. clava. We performed monthly surveys in San Antonio Bay (Argentina) for nearly 1 yr to evaluate U. pinnatifida density (both the total and mature individuals exclusively) on different substrates to determine whether U. pinnatifida was more closely associated with S. clava than with inert substrates (i.e. consolidated and nonconsolidated). Moreover, we compared the morphometry of U. pinnatifida between substrates (S. clava vs. rock) and collected S. clava individuals overgrown by U. pinnatifida and classified them by their holdfast coverage to assess their condition (dead or alive). A higher total density of U. pinnatifida was associated with S. clava than with other substrates from autumn to spring. U. pinnatifida individuals growing on S. clava were smaller than those growing on rock. Finally, the probability of S. clava dying increased for individuals with higher holdfast coverage, although the scarcity of dead individuals found suggested a negligible influence. Our findings indicate that whereas U. pinnatifida clearly benefitted from this interaction by appearing earlier in the field and presenting higher densities that could benefit the population when associated with S. clava, for S. clava the relationship appeared more neutral.
Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid: inhibitory effect of serum
Authors: Pacherník J , Bryja V , Ešner M , Kubala L , Dvořák P , Hampl A
Published: May 2022

In both embryonal carcinoma (EC) and embryonic stem (ES) cells, the differentiation pathway entered after treatment with retinoic acid (RA) varies as it is based upon different conditions of culture. This study employs mouse EC cells P19 to investigate the effects of serum on RA-induced neural differentiation occurring in a simplified monolayer culture. Cell morphology and expression of lineage-specific molecular markers document that, while non-neural cell types arise after treatment with RA under serum-containing conditions, in chemically defined serum-free media RA induces massive neural differentiation in concentrations of 10(-9) M and higher. Moreover, not only neural (Mash-1) and neuroectodermal (Pax-6), but also endodermal (GATA-4, alpha-fetoprotein) genes are expressed at early stages of differentiation driven by RA under serum-free conditions. Furthermore, as determined by the luciferase reporter assay, the presence or absence of the serum does not affect the activity of the retinoic acid response element (RARE). Thus, mouse EC cells are able to produce neural cells upon exposure to RA even without culture in three-dimensional embryoid bodies (EBs). However, in contrast to standard EBs-involving protocol(s), neural differentiation in monolayer only takes place when complex signaling from serum factors is avoided. This simple and efficient strategy is proposed to serve as a basis for neurodifferentiation studies in vitro.
Process Optimization for Dual Laser Beam Joining for Dissimilar Plastics
Authors: Kim Suwon , Choi PilGong , Choi Soo Jin , Han Sang Bae , Choi Jiyeon , Kim Jeng O , Sohn Hyonkee , Ahn Sanghoon , Noh Jiwhan , Kang Heeshin , Jung Kwangyun , Kim Dohyun , Kim Hyun-Deok , Park Changkyoo
Published: May 2022

A dual laser beam joining process is introduced for joining dissimilar plastics. A customized laser head was built, and two different diode lasers with central wavelengths of 980 and 1940 nm were simultaneously applied to obtain PMMA/PC-1 and PC-2/ABS joints. Various experimental conditions were employed for the dual laser beam joining, which were performed at different laser powers for the 1940 nm laser beam and a fixed laser power for the 980 nm laser beam. The tensile shear force of the PMMA/PC-1 and PC-2/ABS joints was measured, and compared with those using the 980 nm single laser beam joining process. For both joints, a decrease in tensile shear force was observed when the laser power of the 1940 nm laser beam increased. Only the dual laser beam joining using the 1940 nm laser beam at the smallest laser power showed relatively higher tensile shear force than those of the 980 nm single laser beam joining. The transmission values of the PMMA and PC-2 at the wavelength of 980 nm were measured with different powers of 1940 nm laser beam, and a correlation between the joining properties and transmission values was found.
Preparation and Thermoelectric Properties of Si-Doped Tetrahedrites Cu12Sb4-ySiyS13
Authors: Kwon Min-Cheol , Kim Il-Ho
Published: May 2022

Si-doped Cu12Sb4-ySiyS13 (y = 0.1-0.4) compounds were prepared using solid-state synthesis. Each specimen consisted of a single tetrahedrite phase with a densely sintered body whose relative density exceeded 98.9%. The lattice constant decreased from 1.0357 nm to 1.0336 nm as the Si content increased. When the Si doping content (y) exceeded 0.3, the decrease in the lattice constant was reduced and residual Si appeared. This established the solubility limit of Si at the Sb sites was y = 0.3. The Seebeck coefficient increased with the temperature and Si content, achieving a maximum value of 178 µVK-1 at 723 K for y = 0.3. For the specimens with y ≤ 0.2, the electrical conductivity increased with temperature, and then slightly decreased at temperatures higher than 623 K, while it gradually increased with temperature for the specimens with y ≥ 0.3. The electrical conductivity decreased as the Si content increased at a constant temperature and the highest electrical conductivity of (2.8-3.4) × 104 Sm-1 was obtained at 323–723 K for Cu12Sb3.9Si0.1S13. When y = 0.4, the electrical conductivity did not decrease further, which is related to the solubility limit of Si. The power factor reached a maximum value of 0.86 mWm-1K-2 at 723 K for Cu12Sb3.9Si0.1S13. As the Si content increased, the thermal conductivity tended to decrease, and Cu12Sb3.7Si0.3S13 exhibited the lowest thermal conductivity of 0.85 Wm-1K-1 at 723 K. Hence, the highest dimensionless figure of merit, ZT = 0.63 was achieved at 723 K for Cu12Sb3.8Si0.2S13.
Synthesis of N-type Bi2Te2.7Se0.3 Compounds through Oxide-Reduction Process and Related Thermoelectric Transport Properties
Authors: Lim Young Soo , Park Bae Gun , Lee Gil-Geun
Published: May 2022

We present a study on the synthesis of Bi2Te2.7Se0.3 powders through an oxide reduction process and also on the effect of the oxide reduction process on the thermoelectric transport properties of the resulting Bi2Te2.7Se0.3 compounds. Starting materials of Bi2O3, TeO2 and SeO2 were mechanical milled for homogeneous mixing, and then oxidized to prepare complex oxide powders. The complex oxide powders were reduced at different reduction temperatures under hydrogen atmosphere, and a single phase of Bi2Te2.7Se0.3 could be achieved in the reduced powder, with shorter reduction times as the reduction temperature was increased. The shape of the synthesized powder particles changed from granules to flakes with increasing reduction temperature and longer reduction time. Bi2Te2.7Se0.3 powders with different shapes were consolidated by spark plasma sintering (SPS). The SPSed Bi2Te2.7Se0.3 compounds exhibited anisotropic n-type thermoelectric transport properties along the vertical and parallel planes with respect to the pressing direction of the SPS. The degree of anisotropy in the thermoelectric properties was quite consistent with the degree of anisotropy in the microstructure, which originated from the anisotropic shapes in the Bi2Te2.7Se0.3 powders depending on the reduction conditions. Detailed thermoelectric transport properties of the n-type Bi2Te2.7Se0.3 compounds were interpreted in terms of anti-site defect formation and their structural anisotropy.
“52 Erkek 52 Hafta” Yazı Dizisi ve Türkiye’de Kadına Yönelik Şiddeti, Erkeklerin Şiddet Anlatıları Üzerinden Tartışmak | The Article Series of “52 Men 52 Weeks” and Discussing the Violence against Women via the Men’s Narratives of Violence
Authors: LEYLA KUZU Şenay
Published: May 2022

Bu çalışma toplumsal cinsiyet çalışmalarında merkezi bir konu olan kadına yönelik şiddet tartışmalarını “52 Erkek 52 Hafta” yazı dizisi örneğinden hareketle tartışmayı amaçlamaktadır. Kadına yönelik şiddet meselesi ilkin kadın hareketi içinde önemli bir tartışma konusuyken daha sonra konu hem kurumsal mekanizmalara hem de akademik alana taşınmıştır. Son dönemlerde ise kadına yönelik şiddet meselesi yeni medya araçları ile geniş bir tartışma alanına kavuşmuştur. Bu sebeple şiddetin biçimleri, nedenleri, kadınlar ve erkekler tarafından nasıl deneyimlendiği hakkında hem nicel hem de nitel verilere daha çok ihtiyaç olduğu anlaşılmaktadır. Feminist çalışmalara, erkeklerin başta şiddet olmak üzere çeşitli deneyimlerinin dâhil edilmesi görece geç olmuştur. Toplumsal cinsiyet meselelerinin ilişkisel boyutu dikkate alındığında erkeklerin deneyimleri önemli olmaktadır. İşte bu çalışma 2018 yılında yayınlanan “52 Erkek 52 Hafta” yazı dizisinden yola çıkarak hem erkeklerin kişisel deneyimlerinde şiddetin yerini hem de Türkiye’deki toplumsal cinsiyet ilişkilerine dair görüşlerini Maxqda nitel veri analizi programından yararlanarak analiz etmektedir. Bu sayede en yaygın şiddet türleri, şiddetin deneyimlendiği alanlar ve şiddetin nedenleri konusunda veriler düzenlenirken şiddetin hem erkeklerin deneyimlerinde kurucu bir öğe olduğu hem de erkeklik inşa sürecine sızdığını görmek mümkündür. Yazı dizisinde sırasıyla en çok psikolojik şiddet, cinsel şiddet, fiziksel şiddet ve ekonomik şiddet tartışma konusu yapılırken, şiddetin deneyimlendiği alanlar olarak aile, okul, işyeri ve sokak sıralanmaktadır. Şiddetin nedenleri arasında kültürel toleransın yüksek olması, ataerkilliğin içselleştirilmesi ve erkeklerin kırılganlığı veya güvensizliği ön plana çıkmaktadır. Erkeklerin de kadına yönelik şiddet meselesini tartışması ve feminist harekete/kadınlara destek vermesi ise en çok tekrarlanan çözüm önerisi olmaktadır.
Improving the Stability of a Hemipelvic Prosthesis Based on Bone Mineral Density Screw Channel and Prosthesis Optimization Design
Authors: Zhou Rongqi , Xue Haowen , Wang Jincheng , Wang Xiaonan , Wang Yanbing , Zhang Aobo , Zhang Jiaxin , Han Qing , Zhao Xin
Published: May 2022

In pelvic reconstruction surgery, the hemipelvic prosthesis can cause significant changes in stress distribution due to its high stiffness, and its solid structure is not suitable for osseointegration. The purpose of this study was to identify a novel bone mineral density screw channel and design the structure of the prosthesis so as to improve the distribution of stress, promote bone growth, and enhance the biomechanical properties of the prosthesis. The mechanical characteristics of bone mineral density screw and traditional screw were compared by finite element analysis method, and redesigned by topology optimization. The direction of the newly proposed screw channel was the posterolateral entrance of the auricular surface, ending at the contralateral sacral cape. Compared to the original group, the maximum stress of the optimized prosthesis was decreased by 24.39%, the maximum stress of the sacrum in the optimized group was decreased by 27.23%, and the average strain energy density of the sacrum in the optimized group was increased by 8.43%. On the surface of screw and connecting plate, the area with micromotion more than 28 μm is reduced by 12.17%. On the screw surface, the area with micromotion more than 28 μm is reduced by 22.9%. The newly determined screw channel and optimized prosthesis design can effectively improve the biomechanical properties of a prosthesis and the microenvironment of osseointegration. This method can provide a reference for the fixation of prostheses in clinical pelvic reconstruction.
Identifying In Vitro Cultured Human Hepatocytes Markers with Machine Learning Methods Based on Single-Cell RNA-Seq Data
Authors: Li ZhanDong , Huang FeiMing , Chen Lei , Huang Tao , Cai Yu-Dong
Published: May 2022

Cell transplantation is an effective method for compensating for the loss of liver function and improve patient survival. However, given that hepatocytes cultivatedin vitrohave diverse developmental processes and physiological features, obtaining hepatocytes that can properly functionin vivois difficult. In the present study, we present an advanced computational analysis on single-cell transcriptional profiling to resolve the heterogeneity of the hepatocyte differentiation processin vitroand to mine biomarkers at different periods of differentiation. We obtained a batch of compressed and effective classification features with the Boruta method and ranked them using the Max-Relevance and Min-Redundancy method. Some key genes were identified during thein vitroculture of hepatocytes, includingCD147, which not only regulates terminally differentiated cells in the liver but also affects cell differentiation.PPIA, which encodes a CD147 ligand, also appeared in the identified gene list, and the combination of the two proteins mediated multiple biological pathways. Other genes, such asTMSB10,TMEM176B, andCD63, which are involved in the maturation and differentiation of hepatocytes and assist different hepatic cell types in performing their roles were also identified. Then, several classifiers were trained and evaluated to obtain optimal classifiers and optimal feature subsets, using three classification algorithms (random forest, k-nearest neighbor, and decision tree) and the incremental feature selection method. The best random forest classifier with a 0.940 Matthews correlation coefficient was constructed to distinguish different hepatic cell types. Finally, classification rules were created for quantitatively describing hepatic cell types. In summary, This study provided potential targets for cell transplantation associated liver disease treatment strategies by elucidating the process and mechanism of hepatocyte development at both qualitative and quantitative levels.
Tips, Tricks, and Potential Pitfalls of CRISPR Genome Editing in Saccharomyces cerevisiae
Authors: Antony Jacob S. , Hinz John M. , Wyrick John J.
Published: May 2022

The versatility of clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) genome editing makes it a popular tool for many research and biotechnology applications. Recent advancements in genome editing in eukaryotic organisms, like fungi, allow for precise manipulation of genetic information and fine-tuned control of gene expression. Here, we provide an overview of CRISPR genome editing technologies in yeast, with a particular focus on Saccharomyces cerevisiae. We describe the tools and methods that have been previously developed for genome editing in Saccharomyces cerevisiae and discuss tips and experimental tricks for promoting efficient, marker-free genome editing in this model organism. These include sgRNA design and expression, multiplexing genome editing, optimizing Cas9 expression, allele-specific editing in diploid cells, and understanding the impact of chromatin on genome editing. Finally, we summarize recent studies describing the potential pitfalls of using CRISPR genome targeting in yeast, including the induction of background mutations.
Analysis of the Current Maintenance Management Process in School Buildings: Study Area of Primorje-Gorski Kotar County, Republic of Croatia
Authors: Tijanić Štrok Ksenija , Marenjak Saša , Car-Pušić Diana
Published: May 2022

Due to their educational purpose, impact on users and quality of education, school buildings are vital institutions in the community, and their adequate maintenance should be mandatory. Studies conducted around the world point to specific inadequacies that occur in the school maintenance segment, however studies that examine the entire maintenance management process in detail are rare. With such studies, it is possible to observe all components of maintenance and its management in the observed buildings, it is possible to get a detailed insight into the present inadequacies and problems, and give the best possible answer to them. Observing the territory of the Republic of Croatia, it was noticed that there are no adequate databases on school building maintenance. Given all the above, this paper aims to establish a methodological framework and analyze the entire maintenance management process in Croatian schools to detect potential inadequacies, reveal problems, and identify areas for action to improve maintenance performance and carry out maintenance more efficiently. The current maintenance management process of elementary school buildings in the Primorje-Gorski Kotar County, Republic of Croatia, was examined based on the developed methodological framework. Data on the management process were collected through a questionnaire survey among school principals. The questionnaire was compiled based on an extensive literature review. Maintenance performance through management functions was investigated, namely: maintenance planning, maintenance organization, maintenance directing, and maintenance controlling. Important management factors within each of the mentioned functions were observed. The data analysis revealed specific inadequacies and problems in the maintenance process, and it was shown that maintenance management is not entirely effective. Recommendations were given to improve the current situation. In this way, it is possible to quickly and easily examine the entire management process and identify measures that need to be introduced in schools to improve their business in the maintenance segment. The developed methodological framework can be applied to schools from other areas as well as to other types of buildings.
Maternal Diabetes and Postnatal High-Fat Diet on Pregnant Offspring
Authors: Sinzato Yuri Karen , Paula Verônyca Gonçalves , Gallego Franciane Quintanilha , Moraes-Souza Rafaianne Q. , Corrente José Eduardo , Volpato Gustavo Tadeu , Damasceno Débora Cristina
Published: May 2022

Maternal diabetes-induced fetal programming predisposes offspring to type 2 diabetes, cardiovascular disease, and obesity in adulthood. However, lifelong health and disease trajectories depend on several factors and nutrition is one of the main ones. We intend to understand the role of maternal diabetes-induced fetal programming and its association with a high-fat diet during lifelong in the female F1 generation focusing on reproductive outcomes and the possible changes in physiological systems during pregnancy as well as the repercussions on the F2 generation at birth. For this, we composed four groups: F1 female pups from control (OC) or from diabetic dams (OD) and fed with standard (SD) or high-fat diet from weaning to full-term pregnancy. During pregnancy, glucose intolerance and insulin sensitivity were evaluated. In a full-term pregnancy, the maternal blood and liver were collected to evaluate redox status markers. The maternal blood, placental tissue, and fetal blood (pool) were collected to evaluate adiponectin and leptin levels. Maternal reproductive parameters were evaluated as well. Maternal diabetes and high-fat diet consumption, in isolation, were both responsible for increased infertility rates and fasting glucose levels in the F1 generation and fetal growth restriction in the F2 generation. The association of both conditions showed, in addition to those, increased lipoperoxidation in maternal erythrocytes, regardless of the increased endogenous antioxidant enzyme activities, glucose intolerance, decreased number of implantation sites and live fetuses, decreased litter, fetal and placental weight, increased preimplantation losses, and increased fetal leptin serum levels. Thus, our findings show that fetal programming caused by maternal diabetes or lifelong high-fat diet consumption leads to similar repercussions in pregnant rats. In addition, the association of both conditions was responsible for glucose intolerance and oxidative stress in the first generation and increased fetal leptin levels in the second generation. Thus, our findings show both the F1 and F2 generations harmed health after maternal hyperglycemic intrauterine environment and exposure to a high-fat diet from weaning until the end of pregnancy.
Dynamic Epicardial Contribution to Cardiac Interstitial c-Kit and Sca1 Cellular Fractions
Authors: Pogontke C. , Guadix J. A. , Sánchez-Tévar A. M. , Muñoz-Chápuli R. , Ruiz-Villalba A. , Pérez-Pomares J. M.
Published: May 2022

Background: The cardiac interstitial cellular fraction is composed of multiple cell types. Some of these cells are known to express some well-known stem cell markers such as c-Kit and Sca1, but they are no longer accepted to be true cardiac stem cells. Although their existence in the cardiac interstitium has not been disputed, their dynamic throughout development, specific embryonic origin, and potential heterogeneity remain unknown. In this study, we hypothesized that both c-KitPOS and Sca1POS cardiac interstitial cell (CIC) subpopulations are related to the Wilms’ tumor 1 (Wt1) epicardial lineage.

Methods: In this study, we have used genetic cell lineage tracing methods, immunohistochemistry, and FACS techniques to characterize cardiac c-KitPOS and Sca1POS cells.

Results: Our data show that approximately 50% of cardiac c-KitPOS cells are derived from the Wt1-lineage at E15.5. This subpopulation decreased along with embryonic development, disappearing from P7 onwards. We found that a large proportion of cardiac c-KitPOS cells express specific markers strongly suggesting they are blood-borne cells. On the contrary, the percentage of Sca1POS cells within the Wt1-lineage increases postnatally. In accordance with these findings, 90% of adult epicardial-derived endothelial cells and 60% of mEFSK4POS cardiac fibroblasts expressed Sca1.

Conclusion: Our study revealed a minor contribution of the Wt1-epicardial lineage to c-KitPOS CIC from embryonic stages to adulthood. Remarkably, a major part of the adult epicardial-derived cell fraction is enriched in Sca1, suggesting that this subpopulation of CICs is heterogeneous from their embryonic origin. The study of this heterogeneity can be instrumental to the development of diagnostic and prognostic tests for the evaluation of cardiac homeostasis and cardiac interstitium response to pathologic stimuli.
Mature Myotubes Generated From Human-Induced Pluripotent Stem Cells Without Forced Gene Expression
Authors: Fujiwara Kei , Yamamoto Risa , Kubota Tomoya , Tazumi Atsutoshi , Sabuta Tomoka , Takahashi Masanori P. , Sakurai Hidetoshi
Published: May 2022

Human-induced pluripotent stem cells (hiPSCs) are a promising tool for disease modeling and drug screening. To apply them to skeletal muscle disorders, it is necessary to establish mature myotubes because the onset of many skeletal muscle disorders is after birth. However, to make mature myotubes, the forced expression of specific genes should be avoided, as otherwise dysregulation of the intracellular networks may occur. Here, we achieved this goal by purifying hiPSC-derived muscle stem cells (iMuSC) by Pax7-fluorescence monitoring and antibody sorting. The resulting myotubes displayed spontaneous self-contraction, aligned sarcomeres, and a triad structure. Notably, the phenotype of sodium channels was changed to the mature type in the course of the differentiation, and a characteristic current pattern was observed. Moreover, the protocol resulted in highly efficient differentiation and high homogeneity and is applicable to drug screening.
Exploring Health Experts' and Creative Communicators' Focus in Pandemic Video Communication: A Qualitative Study
Authors: Shortt Marie Therese , Berg Siv Hilde , Wiig Siri , Lungu Daniel Adrian , Smeets Ionica , Thune Henriette , Røislien Jo
Published: May 2022

Pandemic video communication aimed at the general public often lacks creativity and fails to reach large audiences. Yet, the scientific content should not be compromised by attempts to improve the creativity or reach. This study explores the processes utilised by various health experts and professional communicators when creating communication, to identify similarities and differences, and how pandemic video communication thus can be improved through an interdisciplinary approach. We interviewed 12 individuals from 6 different professional domains: health, public health, film/science communication, video journalism, advertising, and social media/YouTube. Semi-structured individual interviews were conducted using the same interview guide. The interview data were subjected to thematic analysis with both deductive and inductive coding, and the results were visualised in a bubble chart. Our study has highlighted both similarities and differences between health professionals and creative communicators relating to their creative processes and their approaches to pandemic video communication. We found that participants from health domains assigned great importance to and efforts on the content, but were unsure or lacked experience in how content is translated through form and creativity. Creative communicators, on the other hand, emphasise and specialise in form, yet depend on health professionals, experts, and scientists to provide and validate content. The key to improving pandemic-related video communication appears to lie in striking the right balance between high-quality and evidence-based content and creativity. This study found that both health professionals and creative communicators play crucial roles in reaching a solid end result, and we suggest a fusion model approach to interdisciplinary collaboration.
Effect of Sacubitril-Valsartan on Restoration and Maintenance of Sinus Rhythm in Patients With Persistent Atrial Fibrillation
Authors: Chen Qingsong , Chen Yunlin , Qin Fang , Du Huaan , Gan Chunxia , Zhou Bei , Wang Na , Xiao Mingyang , Ou Zhenhong , Zhao Wei , Cui Ben , Liu Zengzhang , Yin Yuehui
Published: May 2022

Background

Existing studies have shown that sacubitril-valsartan ameliorated atrial remodeling in atrial fibrillation (AF) and favored maintenance of sinus rhythm in patients with AF and heart failure. However, the effect of sacubitril-valsartan in patients with persistent AF is yet unknown. We aimed to evaluate the effect of sacubitril-valsartan on restoration and maintenance of sinus rhythm in patients with persistent AF who underwent electrical cardioversion (ECV).

Method

Consecutive patients with persistent AF who underwent ECV between 1 January 2016 and 30 September 2020 were investigated in this retrospective cohort study. All eligible patients were categorized into sacubitril-valsartan users and sacubitril-valsartan non-users based on whether they received treatment with sacubitril-valsartan or not. The endpoint was ineffictive ECV, defined as the composite of failure to terminate AF or any recurrence of AF during 30 days follow-up.

Results

A total of 76 patients were enrolled in this study, including 28 sacubitril-valsartan users and 48 non-users. Within a follow-up of 30 days after ECV, the endpoint had occurred in 7 (25%) of 28 sacubitril-valsartan users and 25 (52%) of 48 non-users. Significantly lower rate of ineffictive ECV in sacubitril-valsartan users compared with non-users was shown in Kaplan-Meier survival curves (P = 0.02; Log-rank test). Multivariate Cox regression analysis indicated that sacubitril-valsartan use (hazard ratio [HR], 0.35; 95% confidence interval [CI], 0.14–0.91), amiodarone use (HR, 0.32; 95% CI, 0.13–0.78), left atrial diameter ≤ 39 mm (HR, 0.21; 95% CI, 0.06–0.71) were independently associated with a decreased rate of ineffective electrical cardioversion.

Conclusion

Use of sacubitril-valsartan is associated with a significantly decreased risk of ineffective ECV compared with non-users in patients with persistent AF.
Comparison of Underground Coal Mining Methods Based on Life Cycle Assessment
Authors: Wu Haoyuan , Yin Zhiqiang , Zhang Yuchen , Qi Chao , Liu Xian , Wang Jianen
Published: May 2022

Coal is China’s main source of energy, and its production causes a certain degree of air, water, and land resource pollution. Therefore, it is necessary to compare environmental pollution caused by different mining methods. When mining underground coal resources, different mining methods have different levels of environmental impacts. To identify the mining method with the least environmental impact, different mining methods were evaluated by means of a life cycle assessment using Simapro 9.0.0 software. The Ecoinvent v3 database was used to provide background data, and the results were calculated using the Eco-indicator99 method. The findings show that for a 20 m coal column, respiratory inorganics were identified as the dominant impact category based on normalized results, followed by fossil fuels, carcinogens, and climate change. The contribution analysis indicated that electricity and coal mining are fundamental in contributing to these significant impact categories and should be of particular concern. According to the sensitivity analysis, reducing mining activities and increasing extraction efficiency and use are the primary responses to addressing environmental pollution, followed by reducing environmental pollution caused by electricity and steel production. In addition, a summary comparison of the single scores of different mining methods suggests that the environmental burden of pillarless mining is the lowest, and as the width of the coal pillar gradually increases, its single score shows a trend of increasing and then decreasing. Therefore, the single score of non-pillar mining is the lowest compared to that of other mining methods and can be the optimal mining method. This study can provide a scientific basis for the selection of green mining and underground coal resource mining methods.