bluuebunny/crossref_metadata_2025 huggingface dataset:
When POTS is the tip of the iceberg: Rare cases of dysautonomia as a possible manifestation of another disorder
Authors: Blitshteyn Svetlana
Published: January 2021

Background

Postural tachycardia syndrome (POTS) is a heterogenous disorder of the autonomic nervous system that is commonly associated with small fiber neuropathy, Ehlers-Danlos Syndrome and autoimmune disorders, but association with rare conditions may also occur.

Methods

Reported here are clinical features, diagnostic tests and treatment outcomes of 6 unique patients who presented with POTS and were subsequently diagnosed with Fabry disease, McArdle disease, Complex V mitochondrial disease, carcinoid tumor, Hodgkin’s lymphoma and chemotherapy-induced neuropathy.

Results

All patients (age range 15-57 years, 3 females, 3 males) presented with orthostatic intolerance of at least 6 months duration, and all patients had co-morbid small fiber neuropathy. Five patients presented with symptoms of POTS months to years before the underlying or associated medical condition was discovered, and three out of six patients experienced either complete resolution or significant improvement of POTS after treatment of the underlying or associated medical condition.

Conclusion

In rare cases, POTS can present as a possible manifestation of genetic, neoplastic or neurotoxic disorders. Unusual clinical features that fall outside of the typical spectrum of dysautonomia can point toward the presence of another disorder and help guide further diagnostic investigation.
Role Stress, Burnout, and Workplace Support Among Newly Recruited Social Workers
Authors: Tang Xiaoqing , Li Xiao
Published: January 2021

Purpose:

This study examines the mediation and moderation roles of workplace support in the effect of role stress on burnout among newly recruited social workers in mainland China.

Method:

A total of 1,638 newly recruited social workers, those in their first year of professional employment, are invited as participants to complete a questionnaire package, which includes their demographic information, role stress, workplace support, and Maslach’s Burnout Inventory.

Results:

Role stress significantly correlates with emotional exhaustion, depersonalization, and decreased personal accomplishment of burnout. Workplace support moderates the effects of role stress on three syndromes of burnout. In addition, role stress can lead to burnout by reducing perceptions of workplace support.

Conclusions:

Workplace support is important in buffering the effect of role stress on burnout. Results suggest interventions on improving workplace support to alleviate role stress and burnout of new social workers would be beneficial.
Finite element modelling of plain and reinforced concrete specimens with the Kotsovos and Pavlovic material model, smeared crack approach and fine meshes
Authors: Markou George , Roeloffze Wynand
Published: January 2021

Modelling of concrete through 3 D constitutive material models is a challenging subject due to the numerous nonlinearities that occur during the monotonic and cyclic analysis of reinforced concrete structures. Additionally, the ultimate limit state modelling of plain concrete can lead to numerical instabilities given the lack of steel rebars that usually provide with the required tensile strength inducing numerical stability that is required during the nonlinear solution procedure. One of the commonly used 3 D concrete material models is that of the Kotsovos and Pavlovic, which until recently it was believed that when integrated with the smeared crack approach, it can only be used in combination with relatively larger in size finite elements. The objective of this study is to investigate into this misconception by developing different numerical models that foresee the use of fine meshes to simulate plain concrete and reinforced concrete specimens. For the needs of this research work, additional experiments were performed on cylindrical high strength concrete specimens that were used for additional validation purposes, whereas results on a reinforced concrete beam found in the international literature were used as well. A discussion on the numerical findings will be presented herein by comparing the different experimental data with the numerically predicted mechanical response of the under study concrete material model.
Harsh Parenting and Child Brain Morphology: A Population-Based Study
Authors: Cortes Hidalgo Andrea P. , Thijssen Sandra , Delaney Scott W. , Vernooij Meike W. , Jansen Pauline W. , Bakermans-Kranenburg Marian J. , van IJzendoorn Marinus H. , White Tonya , Tiemeier Henning
Published: January 2021

Evidence suggests that maltreatment shapes the child’s brain. Little is known, however, about how normal variation in parenting influences the child neurodevelopment. We examined whether harsh parenting is associated with the brain morphology in 2,410 children from a population-based cohort. Mothers and fathers independently reported harsh parenting at child age 3 years. Structural and diffusion-weighted brain morphological measures were acquired with MRI scans at age 10 years. We explored whether associations between parenting and brain morphology were explained by co-occurring adversities, and whether there was a joint effect of both parents’ harsh parenting. Maternal harsh parenting was associated with smaller total gray (β = −0.05 (95%CI = −0.08; −0.01)), cerebral white matter and amygdala volumes (β = −0.04 (95%CI = −0.07; 0)). These associations were also observed with the combined harsh parenting measure and were robust to the adjustment for multiple confounding factors. Similar associations, although non-significant, were found between paternal parenting and these brain outcomes. Maternal and paternal harsh parenting were not associated with the hippocampus or the white matter microstructural metrics. We found a long-term association between harsh parenting and the global brain and amygdala volumes in preadolescents, suggesting that adverse rearing environments common in the general population are related to child brain morphology.
Reflecting on Our Times: Valuing Transformative Leadership in Real-World “Living Systems”
Authors: Atkinson John , Lasbennes Florence , Nabarro David
Published: January 2021

We present this brief reflection on key aspects of the 2030 Agenda for Sustainable Development and the implications of the worldwide focus on achieving the sustainable development goals as external observers of the evaluation endeavor around the world. We have conducted and participated in evaluations, but it is not our primary field of work and we are not engaged in the global community of evaluation specialists. However, we believe that the urgency of the challenges confronting the world today should inspire those influencing and shaping evaluation internationally to focus much more fiercely on the value of evaluation and its implications for leadership at all levels and in all fields of work. We propose that evaluation as practice should support and help inspire, value, and evaluate the type of leadership that the world needs now—dynamic and purposeful “living systems” leaders working toward large-scale, drastic change.
Impact of risk aversion, reactance proneness and risk appraisal on travel destination risk perception
Authors: Prince Melvin , Kim Young
Published: January 2021

The aim of the study is to investigate the motivational effects of tourist traits and risk appraisal on tourist destination risk perception. Risk appraisal involves subjective estimates of vulnerability to a threat and the threat’s consequential severity. Fear levels influence both of these elements of risk appraisal. Individual differences in reactance proneness and risk aversion are introduced into the study model to more fully account for differences in travel destination risk perceptions. The study design involves US adults, who have used their passports for international travel in the past 5 years. Travel risk assessments were studied for four destination sites: London, Tokyo, Kuala Lumpur and Istanbul. A general structural model is developed to test hypotheses about antecedents and consequents of risk appraisal and destination risk perception.
Aerial, apparatus, assemblage: Pain, pleasure, kink, and the circus body without organs
Authors: Greenblatt Jordana
Published: January 2021

Addressing intersections of performances, practices, and practitioners of circus aerial and BDSM, I investigate how “play” manifests in both activities. Circus aerial and kink both involve forms of play that experiment with what is possible, tenable, and worthwhile for bodies to do under restrictive and painful conditions. Both practices are both pleasurable and serious, seeking transcendent, less “controlled” experiences, while maintaining the level of control necessary in forms of play involving real risk. Aerialists select their performance apparatuses not just aesthetically, but for the planes of intensity that playing on and with them enables them to traverse in experimentation and performance, mirroring the complex factors determining an individual’s preferred forms of kink play. Combining performance analysis, interviews with kink-involved circus aerial performers, and my own experience as an aerialist and a kink practitioner, in conversation with theories of play and of sexuality, I explore how intersections of pain, pleasure, and play in BDSM and aerial practice inform each other on embodied and aesthetic registers. I argue that, as an assemblage of aerialist and apparatus, the performer engages in a Deleuzian act of becoming, evoking a Body without Organs that, in its play of intensities, is more than incidentally masochistic.
Realising immigration as a human right: public justification and cosmopolitan solidarity
Authors: Martínez David , Elliott Alexander
Published: January 2021

According to David Miller, immigration is not a human right. Conversely, Kieran Oberman makes a case for immigration as a human right. We agree with the latter view, but we show that its starting point is mistaken. Indeed, both Miller and Oberman discuss the right to immigration within the liberal paradigm: it is a right or not depending on the correct balance between the interests of the citizens of a given national state and the interests of the immigrants. Instead, we claim that public justification can underpin immigration as a human right. That said, the public justification of the right to immigration has several counterarguments to rebut. Before we deal with that issue, relying on Jürgen Habermas’s social theory, we examine the legal structures that could support the right to immigration in practice. To be sure, this does not provide the normative justification needed, instead it shows the framework that allows the institutional realization of this right. Then, through a combination of civic and cosmopolitan forms of solidarity, the article discusses the formation of a public sphere, which could provide the justification of the right to immigration.
Wear behavior of microwave-processed Ni-WC8Co-based functionally graded materials
Authors: Kaushal Sarbjeet , Gupta Dheeraj , Bhowmick Hiralal
Published: January 2021

Functionally graded materials are inhomogeneous materials with the gradual change in properties with position. In this research work, functionally graded clad layers of Ni-WC8Co-based materials with varying compositions of WC8Co from 0 to 30 wt% were processed using a cost-effective and energy-efficient microwave hybrid heating technique. Single-layer clads of compositions corresponding to different functionally graded clad layers were also developed through microwave heating for comparing different properties. The processed functionally graded clads were characterized through microstructural analysis (scanning electron microscopy/energy-dispersive X-ray spectroscopy) and Vicker’s microhardness quantification. Microstructure results showed the functionally graded clad of approximately 2 mm thickness was free from any visible pores and interfacial cracks. Microwave heating resulted in the formation of hard phases in the functionally graded clad layers, and these layers exhibited significantly higher microhardness values. Further, the tribological performance of developed functionally graded clad was examined under dry sliding conditions using pin-on-disk-type tribometer. The influence of varying sliding velocities and sliding distances on the wear characteristics of microwave-processed functionally graded clads were investigated. It was observed that microwave-processed functionally graded clad exhibited approximately 95%, and 29% higher wear resistance than the SS-304 substrate and Ni + 30%WC8Co-based single-layer clad respectively owing to its better mechanical properties.
Internal exhaust gas recirculation via reinduction and negative valve overlap for fuel-efficient aftertreatment thermal management at curb idle in a diesel engine
Authors: Joshi Mrunal C , Shaver Gregory M , Vos Kalen , McCarthy James , Farrell Lisa
Published: January 2021

Low air-flow diesel engine strategies are advantageous during low load operation to maintain temperatures of a warmed-up aftertreatment system (ATS) while reducing fuel consumption and engine-out emissions. This paper presents results at curb idle for internal EGR (iEGR) that demonstrate low airflow and reduced engine-out emissions during fuel-efficient ATS temperature maintenance operation. Internal EGR via reinduction and trapping using negative valve overlap (NVO) are compared to each other, conventional operation and to other low airflow approaches including cylinder deactivation (CDA). At 800 RPM/1.3 bar BMEP (curb idle) iEGR via reinduction enables 200°C engine-out temperature combined with 70% lower NO X, 35% lower fuel consumption, and 40% lower exhaust flow rate than conventional thermal management operation. Internal EGR via trapping using NVO resulted in an engine-out temperature of 185°C, with 56% lower NO X and 25% lower fuel consumption than conventional thermal management operation. Both iEGR strategies have lower engine-out temperatures and higher exhaust flow rates than CDA. No external EGR is required for either iEGR strategy. “iEGR via reinduction” outperforms “iEGR via NVO” as a result of higher open cycle efficiency (via less pumping work) and higher closed-cycle efficiency (via higher specific heat ratio).
Writing sociological fiction
Authors: Watson Ash
Published: January 2021

The value of fiction for public sociology and within qualitative research is well established. However, questions about process remain. Drawing from three contemporary projects – a novel, a series of short stories, and a collection of micro-fiction – this article focuses methodological attention on how sociological imagination may be crafted in and with fiction. In particular I discuss the poetics and aesthetic form of a story: the language, mode of storytelling and voice(s) with which a story is told; and the imagery and sensory qualities which bring a story-world to life. By bringing conceptual considerations together with practical concerns, this article aims to extend the considerable body of work on the value of fiction for the production and dissemination of social research.
The social fact in Durkheim’s late work: Structural hermeneutics, positive sociology, and causality
Authors: Carls Paul
Published: January 2021

Émile Durkheim’s late work focuses on représentations collectives, social facts that embody sui generis social forces and that direct behaviour in meaningful ways. The focus on représentations collectives raises questions, but also opens doors for Durkheimian sociology. Many would contend that Durkheim’s focus on représentations collectives introduces a hermeneutical and ideational element that is at odds with his positivist approach. His study of représentations collectives also point to a potentially broad application of his method to the study of culture as a causally autonomous factor in social life. This article will discuss the social fact in Durkheim’s late work in light of these issues. It will argue that représentations collectives are social facts, ‘things’ in Durkheim’s terminology, that are rooted in ritual. They have an objective existence and are causally efficacious, which makes them the object of positive sociology; there is thus no tension between ‘early’ and ‘late’ Durkheim on this point. It will also argue that due to the causally autonomous and inherently meaningful nature of représentations collectives, Durkheim’s approach adds to the Strong Program’s research agenda, albeit with more of a focus on ritual and emotional energy. In so doing the article seeks to build a bridge between the Strong Program and the interaction ritual approach developed by Randall Collins.
Assessment and visualization of performance indicators of reinforced concrete beams by distributed optical fibre sensing
Authors: Berrocal Carlos G , Fernandez Ignasi , Bado Mattia Francesco , Casas Joan R , Rempling Rasmus
Published: January 2021

The implementation of structural health monitoring systems in civil engineering structures already in the construction phase could contribute to safer and more resilient infrastructure. Due to their lightweight, small size and high resistance to the environment, distributed optical fibre sensors stand out as a very promising technology for damage detection and quantification in reinforced concrete structures. In this article, the suitability of embedding robust distributed optical fibre sensors featuring a protective sheath to accurately assess the performance indicators, in terms of vertical deflection and crack width, of three reinforced concrete beams subjected to four-point bending is investigated. The results revealed that a certain strain attenuation occurs in embedded robust distributed optical fibre sensors compared to commonly used thin polyimide-coated distributed optical fibre sensors bonded to steel reinforcement bars. However, the presence of the protective sheath prevented the appearance of strain reading anomalies which has been a frequently reported issue. Performance wise, the robust distributed optical fibre sensors were able to provide a good estimate of the beam deflections with errors of between 12.3% and 6.5%. Similarly, crack widths computed based on distributed optical fibre sensor strain measurements differed by as little as ±20 µm with results from digital image correlation, provided individual cracks could be successfully detected in the strain profiles. Finally, a post-processing procedure is presented to generate intuitive contour plots that can help delivering critical information about the element’s structural condition in a clear and straightforward manner.
MiR-196b Promotes the Invasion and Migration of Lung Adenocarcinoma Cells by Targeting AQP4
Authors: Wu Xuhui , Wu Gongzhi , Zhang Huaizhong , Peng Xuyang , Huang Bin , Huang Mingjiang , Ding Jianyang , Mao Chaofan , Peng Congxiong
Published: January 2021

Objective:

We aimed to investigate the mechanism of the regulatory axis of miR-196b/AQP4 underlying the invasion and migration of lung adenocarcinoma (LUAD) cells.

Methods:

LUAD miRNA and mRNA expression profiles were downloaded from TCGA database and then differential analysis was used to identify the target miRNA. Target gene for the miRNA was obtained via prediction using 3 bioinformatics databases and intersection with the differentially expressed mRNAs searched from TCGA-LUAD. Then, qRT-PCR and western blot were used to validate the expression of miR-196b and AQP4. Dual-luciferase reporter assay was performed to confirm the targeting relationship between miR-196b and AQP4. Transwell assay was used to investigate the migration and invasion of LUAD cells.

Results:

MiR-196b was screened out by differential and survival analyses, and the downstream target gene AQP4 was identified. In LUAD, miR-196b was highly expressed while AQP4 was poorly expressed. Besides, overexpression of miR-196b promoted cell invasion and migration, while overexpression of AQP4 had negative effects. Moreover, the results of the dual-luciferase reporter assay suggested that AQP4 was a direct target of miR-196b. In addition, we also found that overexpressing AQP4 could suppress the promotive effect of miR-196b on cancer cell invasion and migration.

Conclusion:

MiR-196b promotes the invasion and migration of LUAD cells by down-regulating AQP4, which helps us find new molecular targeted therapies for LUAD.
MRI analysis and surgical treatment of Wassel Type IV duplicated thumbs
Authors: Wang Anyuan , Ding Jian , Wang Long , Chu Tinggang , Wu Zhipeng , Gao Weiyang
Published: January 2021

We present the MRI findings for 39 Wassel Type IV duplicated thumbs in 38 patients. We found that MRI revealed the morphology of the cartilaginous connection between the thumb anlages and the location of the deviation corresponding to the classification of Horii, which allowed precise preoperative planning of corrective osteotomies. All 39 thumbs were available for follow-up after surgical reconstruction at a mean of 29 months (range 25 to 39). Four out of nine Horii Type A cases and all 12 Type B, as well as the six Type C and the six Type D cases, achieved good results according to the Tada scoring system. Five Type A cases achieved fair results with residual stiffness of the interphalangeal joint. No secondary operations were needed. We conclude that MRI proved useful in subclassifying Wassel Type IV duplicated thumbs and may aid in planning the osteotomies needed for their reconstruction.

Level of evidence: IV
Arthroscopic dorsal capsulodesis for isolated lunotriquetral interosseous ligament injuries
Authors: Acar Mehmet A. , Özdemir Ali , Eravsar Ebubekir
Published: January 2021

We assessed the outcomes of isolated lunotriquetral ligament injuries in ten patients who underwent arthroscopic dorsal capsulodesis. Data from patient records, radiologic images and arthroscopic video records were evaluated. The patients were evaluated for ulnar-sided wrist pain with history and physical examination. Preoperative radiographs and MRIs for pain aetiology were assessed. The patients underwent arthroscopic dorsal capsulodesis and were evaluated 29 months (range 19–45) after surgery. Nine patients returned to their original jobs. In one patient pain was aggravated with heavy activities. Mean scapholunate angle was 44°. There were significant improvements postoperatively in pinch and grip strength and MAYO wrist, patient-reported wrist evaluation and pain scores. The wrist flexion–extension and the radial ulnar deviation were significantly improved compared with the contralateral hand. We conclude that arthroscopic dorsal capsulodesis offers effective management for isolated lunotriquetral interosseous ligament injuries.

Level of evidence: IV
The prognostic value of seminal anti-sperm antibodies screening in men prepared for ICSI: a call to change the current antibody-directed viewpoint of sperm autoimmunity testing
Authors: El-Sherbiny Ahmed F. , Ali Tamer A. , Hassan Eman A. , Mehaney Amira B. , Elshemy Heba A.
Published: January 2021

Aims:

We aimed to prospectively evaluate the prognostic value of seminal anti-sperm antibodies (ASA) screening in couples prepared for intracytoplasmic sperm injection (ICSI).

Methods:

A prospective comparative study was conducted, including 184 non-azoospermic infertile men scheduled for ICSI. For each patient, detection of ASA in seminal plasma using the ELISA technique was done and its relation to standard semen parameters and ICSI outcomes, including fertilization, embryo development, and pregnancy rates, was analyzed.

Results:

Sperm count, motility, and morphology were negatively affected by existence of seminal ASA ( p = 0.012, 0.006, and 0.011, respectively). However, no statistically significant difference was detected between patients with positive and negative seminal ASA regarding the median values of fertilization (56.3% versus 66.7%, p = 0.091), percentage of couples with grade A embryo development (91.4% versus 89.9%, p = 0.520), and pregnancy rates (31.4% versus 32.2%, p = 0.98) after ICSI.

Conclusion:

ICSI seems able to overcome the problem of ASA in semen. The routine screening of ASA in men prepared for ICSI has no additional prognostic value and cannot be recommended for the time being, until more specific antigen-concerned testing can be developed.
Postal delivery disruptions and the fragility of voting by mail: Lessons from Maine
Authors: Herron Michael C. , Smith Daniel A.
Published: January 2021

Since the onset in early 2020 of the COVID-19 pandemic in the United States, mail-in voting rates in states that have held elections have surged, presumably reflecting the fact that voting by mail is a relatively safe mode of ballot casting during a public health crisis. Matters of health notwithstanding, postal delivery disruptions can place mail-in ballots at risk of rejection on the grounds of lateness. With Maine as a case study, we show that, in the past four general elections, over 10% of vote-by-mail ballots arrived at local elections offices either on Election Day itself or one day earlier. Moreover, of the vote-by-mail ballots most vulnerable to postal delivery disruptions, a greater share of them were cast by unaffiliated voters and Democrats than by Republicans. Our results highlight the fragility of voting by mail in light of concerns about the reliability of the United States Postal Service. While existing research shows that the opportunity to vote by mail is neutral with respect to partisanship, our results highlight an aspect of mail-in balloting that nonetheless has a partisan hue—the extent to which vote-by-mail ballots are vulnerable to mail delays.
Understanding Sporting Social Media Brand Communities, Place and Social Capital: A Netnography of Football Fans
Authors: Fenton Alex , Keegan Brendan James , Parry Keith D.
Published: January 2021

The emergence of social media and digital channels have expanded communication practices and also created new, virtual spaces where sports fans can interact and communicate directly with each other and with clubs. This article examines the potential for social media brand communities to develop a sense of both community and place amongst sports fans. It explores their influence in placemaking initiatives through the bonding and bridging social capital of a football club’s supporters. A netnographic study of a football club’s supporter networks (five channels) and their interactions with social media brand communities was performed. Data gathered from online sources was underpinned by interviews with 25 members of the community. Findings were analysed via NVivo using bridging and bonding social capital as a theoretical lens. The paper makes two primary contributions to knowledge. It enhances our understanding of the impact of SMBCs and their use in a sporting context—an area that has become increasingly significant during the COVID-19 pandemic enforced lockdowns that have kept fans out of venues. It also contributes to our understanding of the influence of placemaking strategies upon the social capital of supporter communities.
Outcome of Cervical Spine Trauma Patients Admitted to the Intensive Care Unit at a Tertiary Government Referral Trauma Center in Nepal
Authors: Shah Gyanendra , Dhakal Gaurav Raj , Gupta Anil , Hamal Pawan Kumar , Dhungana Siddhartha , Poudel Santosh
Published: January 2021

Study Design:

Retrospective study.

Objectives:

Cervical spinal cord injury (SCI) is a devastating event for patient and family. It has a huge impact on society because of intensive resources required to manage the patient in both acute and rehabilitation phases. With the limited resource setting in underdeveloped countries like Nepal, questions are often raised regarding whether the outcome justifies the expenses of their care. The objective was to assess the outcomes of cervical SCI patients admitted to intensive care unit (ICU).

Methods:

All cervical SCI admitted in ICU during May 2017 to August 2018 were included in this study. Demographic details, mode, morphology, and neurological level of injury, intervention performed and outcomes of ICU stay were analyzed.

Results:

Out of 48 patients, 36 (75%) were male and 12 female with mean age 43.9 ± 15.9 years. Fall injury was the commonest mode of injury (83.3%). Most patients presented within 1 to 3 days of injury and C5-C6 (33.3%) was the most common involved level and 75% presented with ASIA A neurology. Mechanical ventilation was required in 95.8% of the patients and 22 patients were operated upon. The average stay in ICU was 15 days and 13 patients died in the ICU.

Conclusions:

Majority of cervical SCI with complete motor paraplegia required ICU care. Inspite of the intensive care, a subset of these patients succumbed to the complications of the injury. Therefore, it is essential to establish trauma ICU care with specific protocols on managing cervical spine injuries.
Successful Long-Term Control of the Syndrome of Episodic Angioedema With Eosinophilia (Gleich Syndrome) With Low-Dose Imatinib Mesylate and Prednisone
Authors: Butterfield Joseph H.
Published: January 2021

The syndrome of episodic angioedema with eosinophilia, first reported over 40 years ago, is a hypereosinophilic disorder that, uniquely, is not associated with end-organ pathology. However, patients develop a constellation of symptoms that include angioedema, urticaria, fatigue, and fever. Episodes are accompanied by massive hypereosinophilia and weight gain. Type II serum cytokine levels (IL-5, IL-13, IL-9, and IL-10) show cyclic variations peaking at or just prior to the peak of eosinophilia and an abnormal Th2 cell phenotype has been reported. Attacks may occur with predictable regularity and have been described in both adults and children. Glucocorticoid therapy reliably reverses symptoms with accompanying diuresis, defervesce, and normalization of the eosinophil count. In this report, a patient who had the syndrome of episodic angioedema with eosinophilia exceeding 20 years is reported. He has had no end-organ damage to date. Testing for the CHIC2 deletion, a surrogate for the FIP1L1-PDGFRA fusion, was negative. Use of imatinib mesylate, initially as a steroid-sparing agent, and subsequently as a maintenance medication, plus low-dose prednisone has provided long-term control of hypereosinophilia and all clinical manifestations.
COVID-19 and Teachers’ Somatic Burden, Stress, and Emotional Exhaustion: Examining the Role of Principal Leadership and Workplace Buoyancy
Authors: Collie Rebecca J.
Published: January 2021

The role of two leadership factors (autonomy-supportive and autonomy-thwarting leadership) and one personal resource (workplace buoyancy) were examined as predictors of three teacher outcomes: somatic burden, stress related to change, and emotional exhaustion. Data were collected from 325 Australian teachers in May, 2020 during the first wave of COVID-19. During this time, many Australian children were being taught remotely from home, while other students were attending schools in-person. Findings showed that autonomy-supportive leadership was associated with greater buoyancy and, in turn, lower somatic burden, stress related to change, and emotional exhaustion (while controlling for covariates, including COVID-19 work situation). Autonomy-thwarting leadership was positively associated with emotional exhaustion. In addition, autonomy-supportive leadership was indirectly associated with the outcomes. The findings provide understanding of factors that may be harnessed to support teachers during subsequent waves of COVID-19 and other future disruptions to schooling that may occur.
The “laborless fuel”: Landscape, energy transitions and natural gas in the postwar U.S.
Authors: Sica Carlo
Published: January 2021

The dire need for an energy transition to mitigate and reverse global warming is inspiring scholars to reexamine political influences on technological systems. The multi-level perspective of the socio-technical transitions framework acknowledges how technological systems are affected by the social and political landscapes where they are built. Energy landscapes literatures elaborate on the socio-technical transitions framework by explaining how the boundaries of landscapes are negotiated in the context of energy transitions. Energy scholars have found that negotiations over the form and purpose of energy landscapes frequently skew in favor of capital accumulation instead of social reproduction. Studies of landscapes in human geography and labor history have shown how the power imbalance energy scholars observed can be corrected by workers and their communities struggling against business owners and the state. Using archival data, I show how U.S. natural gas legislation in the postwar period was intended to limit coalminers’ demands for landscapes of social reproduction. This point matters because the vulnerabilities of industrial capitalism to energy worker organization could be exploited to push for a just and sustainable energy transition like the Green New Deal.
Durkheim in the Neoliberal Organization: Taking Resistance and Solidarity Seriously
Authors: Courpasson David , Younes Dima , Reed Michael
Published: January 2021

Durkheim’s contributions to organization studies have so far been decidedly marginal, and largely concentrated on culture. In this paper, we draw upon his theory of anomie and solidarity to show how a Durkheimian view of contemporary organizations and work has special relevance today for debates about how workers, particularly middle managers, can reshuffle a capacity to resist neoliberal efforts to profoundly disrupt their working conditions, in particular their autonomy to define what is a job well done. We show how Durkheim’s insights can account for the unexpected rekindling of forms of social solidarity in highly competitive and individualistic organizational settings, through dissident efforts that convey a renewal of a certain work ethos severed by neoliberal managerial policies and practices. Recent studies on resistance confirm Durkheim’s view that forms of collective activity, resembling supposedly ‘old’ mechanisms of former days, continue to exist and develop in contemporary societies and organizations, in response to pressure to put people in situations of inter-individual competition that disrupts social relationships.
Cross-sectional study of individual and environmental factors associated with life-space mobility among community-dwelling independent older people
Authors: Miyashita Tomoha , Tadaka Etsuko , Arimoto Azusa
Published: January 2021

Background

Life-space mobility is reflected in comprehensive longevity and health outcomes and is also an important indicator for preventing mortality and decline in well-being among older people. However, a comprehensive framework of life-space mobility and modifiable individual and environmental factors has not been well validated among community-dwelling independent older people, for primary prevention. We examined individual and environmental factors affecting life-space mobility among community-dwelling independent older people.

Methods

This cross-sectional study included 3500 community-dwelling independent older people randomly selected using the National Basic Resident Registration System in Japan. Life-space mobility was measured using the Japanese version of the Life-Space Assessment (LSA) instrument, which is used to assess an individual’s pattern of mobility. Negative multivariate binomial regression analysis was performed in a final sample of 1258 people. Individual factors (including physical, mental, and social characteristics) and environmental factors (including the social and material environment) were measured and analyzed as potential factors.

Results

Negative multivariable binomial regression analysis, adjusted for demographics, showed that LSA score was associated with locomotive syndrome (β = − 0.48, 95% confidence interval [CI] = − 0.24 to − 0.73), depression (β = − 0.29, 95% CI = − 0.03 to − 0.55), health literacy (β = 0.20, 95% CI = 0.39–0.01), and participation in community activities (β = 0.23, 95% CI = 0.03–0.43) among individual factors, and receipt of social support (β = − 0.19, 95% CI = 0.00 to − 0.38) and social network (β = 0.29, 95% CI = 0.48–0.10) among environmental factors.

Conclusions

Our findings suggest that modifiable individual factors and environmental factors are related to life-space mobility among community-dwelling older people.
Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart
Authors: Oikawa Shino , Kai Yuko , Mano Asuka , Ohata Hisayuki , Kurabayashi Atsushi , Tsuda Masayuki , Kakinuma Yoshihiko
Published: January 2021

Background

We previously established that the non-neuronal cardiac cholinergic system (NNCCS) is equipped with cardiomyocytes synthesizes acetylcholine (ACh), which is an indispensable endogenous system, sustaining cardiac homeostasis and regulating an inflammatory status, by transgenic mice overexpressing choline acetyltransferase (ChAT) gene in the heart. However, whole body biological significances of NNCCS remain to be fully elucidated.

Methods and results

To consolidate the features, we developed heart-specific ChAT knockdown (ChATKD) mice using 3 ChAT-specific siRNAs. The mice developed cardiac dysfunction. Factors causing it included the downregulation of cardiac glucose metabolism along with decreased signal transduction of Akt/HIF-1alpha/GLUT4, leading to poor glucose utilization, impairment of glycolytic metabolites entering the tricarboxylic (TCA) cycle, the upregulation of reactive oxygen species (ROS) production with an attenuated scavenging potency, and the downregulated nitric oxide (NO) production via NOS1. ChATKD mice revealed a decreased vagus nerve activity, accelerated aggression, more accentuated blood basal corticosterone levels with depression-like phenotypes, several features of which were accompanied by cardiac dysfunction.

Conclusion

The NNCCS plays a crucial role in cardiac homeostasis by regulating the glucose metabolism, ROS synthesis, NO levels, and the cardiac vagus nerve activity. Thus, the NNCCS is suggested a fundamentally crucial system of the heart.
High-resolution multilocus sequence typing for Chlamydia trachomatis: improved results for clinical samples with low amounts of C. trachomatis DNA
Authors: Pilo Shlomo , Zizelski Valenci Gal , Rubinstein Mor , Pichadze Lea , Scharf Yael , Dveyrin Zeev , Rorman Efrat , Nissan Israel
Published: January 2021

Background

Several Multilocus Sequence Typing (MLST) schemes have been developed for Chlamydia trachomatis. Bom’s MLST scheme for MLST is based on nested PCR amplification and sequencing of five hypervariable genes and ompA. In contrast to other Chlamydia MLST schemes, Bom’s MLST scheme gives higher resolution and phylogenetic trees that are comparable to those from whole genome sequencing. However, poor results have been obtained with Bom’s MLST scheme in clinical samples with low concentrations of Chlamydia DNA.

Results

In this work, we present an improved version of the scheme that is based on the same genes and MLST database as Bom’s MLST scheme, but with newly designed primers for nested-1 and nested-2 steps under stringent conditions. Furthermore, we introduce a third primer set for the sequencing step, which considerably improves the performance of the assay. The improved primers were tested in-silico using a dataset of 141 Whole Genome Sequences (WGS) and in a comparative analysis of 32 clinical samples. Based on cycle threshold and melting curve analysis values obtained during Real-Time PCR of nested-1 & 2 steps, we developed a simple scoring scheme and flow chart that allow identification of reaction inhibitors as well as to predict with high accuracy amplification success. The improved MLST version was used to obtain a genovars distribution in patients attending an STI clinic in Tel Aviv.

Conclusions

The newly developed MLST version showed great improvement of assay results for samples with very low concentrations of Chlamydia DNA. A similar concept could be applicable to other MLST schemes.
Risk factors associated with major adverse cardiac and cerebrovascular events following percutaneous coronary intervention: a 10-year follow-up comparing random survival forest and Cox proportional-hazards model
Authors: Farhadian Maryam , Dehdar Karsidani Sahar , Mozayanimonfared Azadeh , Mahjub Hossein
Published: January 2021

Background

Due to the limited number of studies with long term follow-up of patients undergoing Percutaneous Coronary Intervention (PCI), we investigated the occurrence of Major Adverse Cardiac and Cerebrovascular Events (MACCE) during 10 years of follow-up after coronary angioplasty using Random Survival Forest (RSF) and Cox proportional hazards models.

Methods

The current retrospective cohort study was performed on 220 patients (69 women and 151 men) undergoing coronary angioplasty from March 2009 to March 2012 in Farchshian Medical Center in Hamadan city, Iran. Survival time (month) as the response variable was considered from the date of angioplasty to the main endpoint or the end of the follow-up period (September 2019). To identify the factors influencing the occurrence of MACCE, the performance of Cox and RSF models were investigated in terms of C index, Integrated Brier Score (IBS) and prediction error criteria.

Results

Ninety-six patients (43.7%) experienced MACCE by the end of the follow-up period, and the median survival time was estimated to be 98 months. Survival decreased from 99% during the first year to 39% at 10 years' follow-up. By applying the Cox model, the predictors were identified as follows: age (HR = 1.03, 95% CI 1.01–1.05), diabetes (HR = 2.17, 95% CI 1.29–3.66), smoking (HR = 2.41, 95% CI 1.46–3.98), and stent length (HR = 1.74, 95% CI 1.11–2.75). The predictive performance was slightly better by the RSF model (IBS of 0.124 vs. 0.135, C index of 0.648 vs. 0.626 and out-of-bag error rate of 0.352 vs. 0.374 for RSF). In addition to age, diabetes, smoking, and stent length, RSF also included coronary artery disease (acute or chronic) and hyperlipidemia as the most important variables.

Conclusion

Machine-learning prediction models such as RSF showed better performance than the Cox proportional hazards model for the prediction of MACCE during long-term follow-up after PCI.
The adaptation of older adults’ transition to residential care facilities and cultural factors: a meta-synthesis
Authors: Sun Changxian , Ding Yaping , Cui Yan , Zhu Shuqin , Li Xianwen , Chen Shen , Zhou Rong , Yu Yiting
Published: January 2021

Background

The transition to residential care facilities can be stressful for older people, entailing numerous challenges. Many qualitative studies focused on the adjustment and the experiences associated with older adults’ admission to residential care facilities. However, there have been few studies to synthesize qualitative studies and pay attention to the cultural factors influencing adaptation. The aim is to appraise the adaptation of older people’ s transition to the residential care facilities.

Methods

We followed the method of Preferred Reporting Items of Systematic Review and Meta-Analysis (PRISMA). Six databases (CINHAL, Cochrane, Embase, Pubmed, PsycInfo, and Web of Science) were searched systematically from their inception until April 2020 using Medical Subject Headings (MSH) or Subject Headings plus free-text words. The CASP evaluation for qualitative studies was used for quality appraisal and meta-aggregation was used in the data analysis.

Results

Ten studies (from 7 countries on 3 continents) were included in this review. We synthesized two main findings: the impacts of culture on adaptation and the transition process.

Conclusions

Understanding the cultural factors helps nursing staff to gain new insight into older adults’ transition to residential care facilities. The consideration of cultural factors might be incorporated into tailored interventions for residents during transition. Nursing staff is advised to pay attention to the decision-making process before residents’ admission to the residential care facilities, and care plans are best made by residents, family members, and staff members together at the beginning of the decision-making process.
MIScnn: a framework for medical image segmentation with convolutional neural networks and deep learning
Authors: Müller Dominik , Kramer Frank
Published: January 2021

Background

The increased availability and usage of modern medical imaging induced a strong need for automatic medical image segmentation. Still, current image segmentation platforms do not provide the required functionalities for plain setup of medical image segmentation pipelines. Already implemented pipelines are commonly standalone software, optimized on a specific public data set. Therefore, this paper introduces the open-source Python library MIScnn.

Implementation

The aim of MIScnn is to provide an intuitive API allowing fast building of medical image segmentation pipelines including data I/O, preprocessing, data augmentation, patch-wise analysis, metrics, a library with state-of-the-art deep learning models and model utilization like training, prediction, as well as fully automatic evaluation (e.g. cross-validation). Similarly, high configurability and multiple open interfaces allow full pipeline customization.

Results

Running a cross-validation with MIScnn on the Kidney Tumor Segmentation Challenge 2019 data set (multi-class semantic segmentation with 300 CT scans) resulted into a powerful predictor based on the standard 3D U-Net model.

Conclusions

With this experiment, we could show that the MIScnn framework enables researchers to rapidly set up a complete medical image segmentation pipeline by using just a few lines of code. The source code for MIScnn is available in the Git repository:https://github.com/frankkramer-lab/MIScnn.
Noninvasive real-time assessment of intracranial pressure after traumatic brain injury based on electromagnetic coupling phase sensing technology
Authors: Li Gen , Li Wang , Chen Jingbo , Zhao Shuanglin , Bai Zelin , Liu Qi , Liao Qi , He Minglian , Zhuang Wei , Chen Mingsheng , Sun Jian , Chen Yujie
Published: January 2021

Background

To investigate the feasibility of intracranial pressure (ICP) monitoring after traumatic brain injury (TBI) by electromagnetic coupling phase sensing, we established a portable electromagnetic coupling phase shift (ECPS) test system and conducted a comparison with invasive ICP.

Methods

TBI rabbits’ model were all synchronously monitored for 24 h by ECPS testing and invasive ICP. We investigated the abilities of the ECPS to detect targeted ICP by feature extraction and traditional classification decision algorithms.

Results

The ECPS showed an overall downward trend with a variation range of − 13.370 ± 2.245° as ICP rose from 11.450 ± 0.510 mmHg to 38.750 ± 4.064 mmHg, but its change rate gradually declined. It was greater than 1.5°/h during the first 6 h, then decreased to 0.5°/h and finally reached the minimum of 0.14°/h. Nonlinear regression analysis results illustrated that both the ECPS and its change rate decrease with increasing ICP post-TBI. When used as a recognition feature, the ability (area under the receiver operating characteristic curve, AUCs) of the ECPS to detect ICP ≥ 20 mmHg was 0.88 ± 0.01 based on the optimized adaptive boosting model, reaching the advanced level of current noninvasive ICP assessment methods.

Conclusions

The ECPS has the potential to be used for noninvasive continuous monitoring of elevated ICP post-TBI.