bluuebunny/crossref_metadata_2025 huggingface dataset:
Capacitive Load-Based Smart OTF for High Power Rated SPV Module
Authors: Sayyad Javed , Nasikkar Paresh , Singh Abhaya Pal , Ozana Stepan
Published: February 2021

Solar energy is the most promising renewable resource with an unbounded energy source, capable of meeting all human energy requirements. Solar Photovoltaic (SPV) is an effective approach to convert sunlight into electricity, and it has a promising future with consistently rising energy demand. In this work, we propose a smart solution of outdoor performance characterization of the SPV module utilizing a robust, lightweight, portable, and economical Outdoor Test Facility (OTF) with the Internet of Things (IoT) capability. This approach is focused on the capacitive load-based method, which offers improved accuracy and cost-effective data logging using Raspberry Pi and enables the OTF to sweep during the characterization of the SPV module automatically. A demonstration using an experimental setup is also provided in the paper to validate the proposed OTF. This paper further discusses the advantages of using the capacitive load approach over the resistive load approach. IoT’s inherent benefits empower the proposed OTF method on the backgrounds of real-time tracking, data acquisition, and analysis for outdoor output performance characterization by capturing Current–Voltage (I–V) and Power–Voltage (P–V) curves of the SPV module.
Analysis of Physicochemical Parameters of Congress Worts Prepared from Special Legume Seed Malts, Acquired with and without Use of Enzyme Preparations
Authors: Gasiński Alan , Błażewicz Józef , Kawa-Rygielska Joanna , Śniegowska Joanna , Zarzecki Maciej
Published: February 2021

This study was conducted to produce malt from legume seeds (chickpea, lentil, pea, and vetch) and test whether malting with parameters, typically barley grain, will result in well-modified legume seed malt. Analysis of malt was performed by producing congress worts from legume seed malts. Concentration of phenolic compounds, as well as antioxidant activity of legume seed malts was analysed. Acquired worts were characterised with poor technological characteristics (wort extract, wort volume, saccharification time, brewhouse efficiency); however, the malting process increased concentration of phenolic compounds and antioxidant activity of the plant material. Subsequent mashing tests with addition of different external enzymes and/or gelatinisation of legume seed malt were performed. Use of external enzymes improved saccharification time, extract content, wort volume, as well brewhouse efficiency in the case of some legume seed malts. The best brewhouse efficiencies and highest extract values were acquired by the samples prepared with 30% of gelatinised vetch malt or chickpea malt mixed with 70% of Pilsner malt. The study shows that there is possibility of creating legume seed malts, but malting and mashing characteristics need to be customised for these special malts.
Peptide Gelators to Template Inorganic Nanoparticle Formation
Authors: Bellotto Ottavia , Cringoli Maria C. , Perathoner Siglinda , Fornasiero Paolo , Marchesan Silvia
Published: February 2021

The use of peptides to template inorganic nanoparticle formation has attracted great interest as a green route to advance structures with innovative physicochemical properties for a variety of applications that range from biomedicine and sensing, to catalysis. In particular, short-peptide gelators offer the advantage of providing dynamic supramolecular environments for the templating effect on the formation of inorganic nanoparticles directly in the resulting gels, and ideally without using further reductants or chemical reagents. This mini-review describes the recent progress in the field to outline future research directions towards dynamic functional materials that exploit the synergy between supramolecular chemistry, nanoscience, and the interface between organic and inorganic components for advanced performance.
The Genetics of Sudden Infant Death Syndrome—Towards a Gene Reference Resource
Authors: Johannsen Emma B. , Baughn Linda B. , Sharma Neeraj , Zjacic Nicolina , Pirooznia Mehdi , Elhaik Eran
Published: February 2021

Sudden infant death syndrome (SIDS) is the unexpected death of an infant under one year of age that remains unexplained after a thorough investigation. Despite SIDS remaining a diagnosis of exclusion with an unexplained etiology, it is widely accepted that SIDS can be caused by environmental and/or biological factors, with multiple underlying candidate genes. However, the lack of biomarkers raises questions as to why genetic studies on SIDS to date are unable to provide a clearer understanding of the disease etiology. We sought to improve the identification of SIDS-associated genes by reviewing the SIDS genetic literature and objectively categorizing and scoring the reported genes based on the strength of evidence (from C1 (high) to C5 (low)). This was followed by analyses of function, associations between genes, the enrichment of gene ontology (GO) terms, and pathways and gender difference in tissue gene expression. We constructed a curated database for SIDS gene candidates consisting of 109 genes, 14 of which received a category 4 (C4) and 95 genes received the lowest category of C5. That none of the genes was classified into the higher categories indicates the low level of supporting evidence. We found that genes of both scoring categories show distinct networks and are highly diverse in function and involved in many GO terms and pathways, in agreement with the perception of SIDS as a heterogeneous syndrome. Genes of both scoring categories are part of the cardiac system, muscle, and ion channels, whereas immune-related functions showed enrichment for C4 genes. A limited association was found with neural development. Overall, inconsistent reports and missing metadata contribute to the ambiguity of genetic studies. Considering those parameters could help improve the identification of at-risk SIDS genes. However, the field is still far from offering a full-pledged genetic test to identify at-risk infants and is still hampered with methodological challenges and misunderstandings of the vulnerabilities of vital biological mechanisms.
Genome-Wide Association Analyses of Fertility Traits in Beef Heifers
Authors: Stegemiller Morgan R. , Murdoch Gordon K. , Rowan Troy N. , Davenport Kimberly M. , Becker Gabrielle M. , Hall John B. , Murdoch Brenda M.
Published: February 2021

The ability of livestock to reproduce efficiently is critical to the sustainability of animal agriculture. Antral follicle count (AFC) and reproductive tract scores (RTS) can be used to estimate fertility in beef heifers, but the genetic mechanisms influencing variation in these measures are not well understood. Two genome-wide association studies (GWAS) were conducted to identify the significant loci associated with these traits. In total, 293 crossbred beef heifers were genotyped on the Bovine GGP 50K chip and genotypes were imputed to 836,121 markers. A GWAS was performed with the AFC phenotype for 217 heifers with a multi-locus mixed model, conducted using the year, age at time of sampling and principal component analysis groupings as the covariates. The RTS GWAS was performed with 289 heifers using an additive correlation/trend test comparing prepubertal to pubertal heifers. The loci on chromosomes 2, 3 and 23 were significant in the AFC GWAS and the loci on chromosomes 2, 8, 10 and 11 were significant in the RTS GWAS. The significant region on chromosome 2 was similar between both analyses. These regions contained genes associated with cell proliferation, transcription, apoptosis and development. This study proposes candidate genes for beef cattle fertility, although future research is needed to elucidate the precise mechanisms.
New Chronological Constraints from Hypogean Deposits for Late Pliocene to Recent Morphotectonic History of the Alpi Apuane (NW Tuscany, Italy)
Authors: Isola Ilaria , Mazzarini Francesco , Molli Giancarlo , Piccini Leonardo , Zanella Elena , Zanchetta Giovanni , Drysdale Russell , Hellstrom John , Woodhead Jon , Roncioni Adriano , Milazzo Flavio , Pieruccioni Diego , Regattieri Eleonora
Published: February 2021

A sedimentary sequence of fluvial deposits preserved in the Corchia Cave (Alpi Apuane) provides new chronological constraints for the evolution of the cave system and the timing and rate of uplift of this sector of the Alpi Apuane since the late Pliocene. Supported by magnetostratigraphic analysis performed on fine-grained fluvial deposits, and by radiometric dating of speleothems, we suggest that the deposition of fluvial sediments occurred between ~1.6–1.2 Ma. This implies that the host volume of rock was already located close to the local base level, adding key information about the recent tectonic evolution of the Alpi Apuane. A few before ~1 Ma, an erosive phase occurred due to the base-level lowering, followed by continuous speleothem deposition since at least 0.97 Ma. From that time, Monte Corchia uplifted at a maximum rate of ~0.5 mm/year, which is consistent with isostatic uplift mainly driven by erosional unloading. The petrographical study of the fluvial deposits highlights the presence of material derived from the erosion of rocks that today are absent in the cave’s catchment area, suggesting a different surface morphology during the Early Pleistocene. This study highlights the potential of cave sediments as archives for reconstructing the uplift history of mountain ranges.
Public Trust and Policy Compliance during the COVID-19 Pandemic: The Role of Professional Trust
Authors: Saechang Orachorn , Yu Jianxing , Li Yong
Published: February 2021

Previous research has shown that public trust is vital for promoting policy compliance, particularly in times of crisis. However, the literature supporting this notion remains scarce, especially in countries which have successfully contained a pandemic despite showing a generally low level of public trust in the government. To address this topic, we conducted a cross-sectional study between February and March of 2020 to examine the relationship between public trust and the compliance of the general public in adopting personal protective measures introduced during the early phase of the coronavirus disease 2019 (COVID-19) outbreak in Thailand. We report our result from a hierarchical regression. We find a positive and significant relationship between public trust in the government and the likelihood of respondents adopting these precautions, more importantly, this relationship was fully mediated by the professional trust as the effect of public trust in the government on policy compliance was reduced by 0.118, namely from (β = 0.133, p < 0.001) to (β = 0.015, p > 0.05). Married respondents residing in the capital city, with a higher degree of worry were also more likely to comply with these safety measures. In conclusion, the finding sheds light on the dynamic relationship between public trust and policy compliance and offers some implications in times of a global health crisis.
Modeling of Extreme Hydrological Events in the Baksan River Basin, the Central Caucasus, Russia
Authors: Kornilova Ekaterina D. , Krylenko Inna N. , Rets Ekaterina P. , Motovilov Yuri G. , Bogachenko Evgeniy M. , Krylenko Ivan V. , Petrakov Dmitry A.
Published: February 2021

High mountain areas are prone to extreme hydrological events, and their study is especially important in the context of ongoing intensive deglaciation. In this research, a model “chain” consisting of a hydrodynamic model and a runoff formation model is adopted to simulate a glacier lake outburst flood (GLOF) from Bashkara Lake (the Central Caucasus, Russia) and its effect on downstream. In addition to an actual GLOF event that occurred on 1 September 2017 and led to casualties and significant destruction in the Adylsu and Baksan Rivers valleys, possible scenarios for the re-outburst of the lake are considered. The hydrographs of the outburst and the downstream movement of the flood wave along the Adylsu River valley are estimated using STREAM_2D two-dimensional hydrodynamic model. The water discharges in the entire river network of the Baksan River are assessed using the ECOMAG (ECOlogical Model for Applied Geophysics) runoff formation model. The output flood hydrograph from the hydrodynamic model is set as additional input into the Baksan River runoff formation model in the upper reaches of the Adylsu River. As a result of the simulations, estimates for the contribution of GLOFs and precipitation to an increase in peak discharge along the Baksan River were obtained. The actual outburst flood contributed 45% and precipitation 30% to the peak flow in the Baksan River at the mouth of the Adylsu River (10 km from the outburst site). In Tyrnyauz (40 km from the outburst site), the contributions of the outburst flood and precipitation were equal and, in Zayukovo (70 km from the outburst site), the outburst flood contributed only 20% to the peak flow, whereas precipitation contributed 44%. Similar calculations were made for future potential re-outburst flood, taking into account climatic changes with an increase in air temperatures of 2 °C, an increase in precipitation of 10% in winter and a decrease of 10% in summer. The maximum discharge of the re-outburst flood in the Adylsu River mouth, according to model estimations, will be approximately three times less than the discharge of the actual outburst on 1 September 2017 and can contribute up to 18% of the peak discharge in the Baksan River at the confluence.
Effectiveness of tDCS at Improving Recognition and Reducing False Memories in Older Adults
Authors: Meléndez Juan , Satorres Encarnación , Pitarque Alfonso , Delhom Iraida , Real Elena , Escudero Joaquin
Published: February 2021

Background: False memories tend to increase in healthy and pathological aging, and their reduction could be useful in improving cognitive functioning. The objective of this study was to use an active–placebo method to verify whether the application of transcranial direct current stimulation (tDCS) improved true recognition and reduced false memories in healthy older people. Method: Participants were 29 healthy older adults (65–78 years old) that were assigned to either an active or a placebo group; the active group received anodal stimulation at 2 mA for 20 min over F7. An experimental task was used to estimate true and false recognition. The procedure took place in two sessions on two consecutive days. Results: True recognition showed a significant main effect of sessions (p < 0.01), indicating an increase from before treatment to after it. False recognition showed a significant main effect of sessions (p < 0.01), indicating a decrease from before treatment to after it and a significant session × group interaction (p < 0.0001). Conclusions: Overall, our results show that tDCS was an effective tool for increasing true recognition and reducing false recognition in healthy older people, and suggest that stimulation improved recall by increasing the number of items a participant could recall and reducing the number of memory errors.
Talent Development Environments in Football: Comparing the Top-Five and Bottom-Five-Ranked Football Academies in Norway
Authors: Gangsø Kristian , Aspvik Nils Petter , Mehus Ingar , Høigaard Rune , Sæther Stig Arve
Published: February 2021

Background: The aim of this study was to examine junior-elite football players’ perception of their talent development environment by comparing clubs ranked as the top-five and bottom-five in the 2017 Norwegian academy classification. Methods: In total, 92 male junior-elite football players recruited from under-19 teams from five professional football club academies took part in the study. The Talent Development Environment Questionnaire (TDEQ-5; Martindale et al. 2010) was used to measure the players’ perceptions of their team environment. Results: The subscale long-term development focus and support network had the highest score and indicated that they perceived that the environment was high quality with respect to those factors. Players from the top-five-ranked clubs perceived their development environments to be significantly more positive with respect to holistic quality preparation, alignment of expectations, communication and, compared to players from the bottom-five-ranked clubs. Conclusions: The players’ perceptions of the talent development environment seem to be in alignment of the academy classification undertaken by the Norwegian top football association.
Scoping Review—The Association between Asthma and Environmental Chemicals
Authors: Mattila Tiina , Santonen Tiina , Andersen Helle Raun , Katsonouri Andromachi , Szigeti Tamás , Uhl Maria , Wąsowicz Wojciech , Lange Rosa , Bocca Beatrice , Ruggieri Flavia , Kolossa-Gehring Marike , Sarigiannis Denis A. , Tolonen Hanna
Published: February 2021

Asthma is one of the most common chronic diseases worldwide affecting all age groups from children to the elderly. In addition to other factors such as smoking, air pollution and atopy, some environmental chemicals are shown or suspected to increase the risk of asthma, exacerbate asthma symptoms and cause other respiratory symptoms. In this scoping review, we report environmental chemicals, prioritized for investigation in the European Human Biomonitoring Initiative (HBM4EU), which are associated or possibly associated with asthma. The substance groups considered to cause asthma through specific sensitization include: diisocyanates, hexavalent chromium Cr(VI) and possibly p-phenylenediamine (p-PDA). In epidemiological studies, polyaromatic hydrocarbons (PAHs) and organophosphate insecticides are associated with asthma, and phthalates, per- and polyfluoroalkyl substances (PFASs), pyrethroid insecticides, mercury, cadmium, arsenic and lead are only potentially associated with asthma. As a conclusion, exposure to PAHs and some pesticides are associated with increased risk of asthma. Diisocyanates and Cr(VI) cause asthma with specific sensitization. For many environmental chemicals, current studies have provided contradicting results in relation to increased risk of asthma. Therefore, more research about exposure to environmental chemicals and risk of asthma is needed.
Burnout Syndrome in Paediatric Nurses: A Multi-Centre Study
Authors: De la Fuente-Solana Emilia I. , Pradas-Hernández Laura , González-Fernández Carmen Tamara , Velando-Soriano Almudena , Martos-Cabrera María Begoña , Gómez-Urquiza José L. , Cañadas-De la Fuente Guillermo Arturo
Published: February 2021

Background: Burnout syndrome is an increasingly prevalent problem, characterised by emotional exhaustion (EE), depersonalization (D), and low personal accomplishment (PA), feelings that appear with prolonged exposure to stress-inducing situations. The syndrome alters physical well-being and endangers the quality of services provided. Among nurses working in the paediatric area, the association between burnout and the corresponding risk profile has received little research attention, despite the highly stressful nature of this work. Materials and Methods: The study population was composed of 95 nurses working in four hospitals in the province of Granada. Data were collected using the Maslach Burnout Inventory, the NEO Personality Inventory, and the Educational-Clinical Questionnaire: Anxiety and Depression. Results: According to the results obtained, 22.0% of the nurses working in the paediatric area present high levels of EE, 18.5% present high levels of D, and 39.6% had feelings of low PA. These burnout levels do not depend on sociodemographic or labour variables, but the three domains of the syndrome are related to the psychological factors analysed. Conclusions: Among the nurses who participated in this study, 38.6% presented high levels of burnout, especially regarding feelings of low personal accomplishment. Personality factors play an important role in the development of this syndrome. This study shows the impact of burnout in paediatric nurses as well as the risk factors, providing information for the development of strategies to prevent it.
Youth Sports Participation Is More Important among Females than Males for Predicting Physical Activity in Early Adulthood: Iowa Bone Development Study
Authors: Kwon Soyang , Letuchy Elena M. , Levy Steven M. , Janz Kathleen F.
Published: February 2021

A gender difference in youth sports and physical activity participation is well documented. However, research is limited to understand potential gender difference in the long-term effects of youth sports participation. The study aim was to compare the likelihood of meeting the aerobic Physical Activity Guidelines (PAG) in early adulthood by youth sports participation patterns among females and males. The study sample included 582 Iowa Bone Development Study participants (Iowa, USA). Participation in organized sports was assessed using a physical activity questionnaire 19 times on average between age 6 and 17 years. Accelerometer and dual-energy X-ray absorptiometry assessments were conducted at an average age of 23 years. Group-based trajectory analysis was conducted to identify youth sports participation trajectory patterns. Multivariable logistic regression analysis was conducted to examine the association between youth sports participation patterns and meeting the PAG in adulthood. We identified three youth sports participation patterns: “continuous participation,” “drop-out,” and “no participation.” Females in the continuous participation group were more likely to meet the aerobic PAG at age 23 years, compared to females in the no-participation group (OR = 2.63; 95% CI = 1.05, 6.55) or the drop-out group (OR = 2.55; 95% CI = 1.38, 4.69). However, among males, youth sports participation patterns were not significantly associated with meeting the aerobic PAG at age 23 years. In conclusion, this study suggests that youth sports participation could be more important among females than males for predicting physical activity in early adulthood.
Young Adults View Smartphone Tracking Technologies for COVID-19 as Acceptable: The Case of Taiwan
Authors: Garrett Paul M. , Wang YuWen , White Joshua P. , Hsieh Shulan , Strong Carol , Lee Yi-Chan , Lewandowsky Stephan , Dennis Simon , Yang Cheng-Ta
Published: February 2021

Taiwan has been successful in controlling the spread of SARS-CoV-2 during the COVID-19 pandemic; however, without a vaccine the threat of a second outbreak remains. Young adults who show few to no symptoms when infected have been identified in many countries as driving the virus’ spread through unidentifiable community transmission. Mobile tracking technologies register nearby contacts of a user and notifies them if one later tests positive to the virus, potentially solving this issue; however, the effectiveness of these technologies depends on their acceptance by the public. The current study assessed attitudes towards three tracking technologies (telecommunication network tracking, a government app, and Apple and Google’s Bluetooth exposure notification system) among four samples of young Taiwanese adults (aged 25 years or younger). Using Bayesian methods, we find high acceptance for all three tracking technologies (>75%), with acceptance for each technology surpassing 90% if additional privacy measures were included. We consider the policy implications of these results for Taiwan and similar cultures.
Handling Complex Missing Data Using Random Forest Approach for an Air Quality Monitoring Dataset: A Case Study of Kuwait Environmental Data (2012 to 2018)
Authors: Alsaber Ahmad R. , Pan Jiazhu , Al-Hurban  Adeeba
Published: February 2021

In environmental research, missing data are often a challenge for statistical modeling. This paper addressed some advanced techniques to deal with missing values in a data set measuring air quality using a multiple imputation (MI) approach. MCAR, MAR, and NMAR missing data techniques are applied to the data set. Five missing data levels are considered: 5%, 10%, 20%, 30%, and 40%. The imputation method used in this paper is an iterative imputation method, missForest, which is related to the random forest approach. Air quality data sets were gathered from five monitoring stations in Kuwait, aggregated to a daily basis. Logarithm transformation was carried out for all pollutant data, in order to normalize their distributions and to minimize skewness. We found high levels of missing values for NO2 (18.4%), CO (18.5%), PM10 (57.4%), SO2 (19.0%), and O3 (18.2%) data. Climatological data (i.e., air temperature, relative humidity, wind direction, and wind speed) were used as control variables for better estimation. The results show that the MAR technique had the lowest RMSE and MAE. We conclude that MI using the missForest approach has a high level of accuracy in estimating missing values. MissForest had the lowest imputation error (RMSE and MAE) among the other imputation methods and, thus, can be considered to be appropriate for analyzing air quality data.
Feasibility Study of an Educational Intervention to Improve Water Intake in Adolescent Soccer Players: A Two-Arm, Non-Randomized Controlled Cluster Trial
Authors: Martín-Payo Rubén , Fernández-Álvarez María del Mar , Zabaleta-del-Olmo Edurne , García-García Rebeca , González-Méndez Xana , Carrasco-Santos Sergio
Published: February 2021

This study aimed to assess the feasibility of an educational intervention on hydration behavior in adolescent soccer players. A pilot study of a two-arm, non-randomized controlled cluster trial was conducted. A total of 316 players aged 13–16 agreed to participate. The response variables were the players’ participation in the intervention, their perception of the knowledge acquired, the usefulness and the overall assessment of the intervention. Hydration patterns and acquisition of knowledge on hydration behavior were also assessed. The intervention involved two elements: posters and a web app. A total of 259 adolescents completed the study (intervention group (IG) = 131; control group (CG) = 128). 80.6% of the players responded to the survey assessing the feasibility of the intervention. The mean number of correct answers regarding behavior was significantly higher in the IG (3.54; SD = 1.162) than in the CG (2.64; SD = 1.174) (p < 0.001). The water consumption pattern at all the clubs was ad libitum. Of the players, 10% did not drink any water at all during the game. In conclusion, this intervention has been shown to be feasible for implementation with adolescent soccer players. It suggests that hydration guidelines should be informed by personal factors and that ad libitum water consumption should be avoided.
Gender and Socioeconomic Status as Factors of Individual Differences in Pre-University Students’ Decision-Making for Careers, with a Focus on Family Influence and Psychosocial Factors
Authors: Olmos-Gómez María del Carmen , Luque-Suárez Mónica , Becerril-Ruiz Diego , Cuevas-Rincón Jesús Manuel
Published: February 2021

The present study analyses the influence of family, specifically parents, on the career decisions of their children, and how gender and socioeconomic status influence this choice. Research was carried out using data obtained from a questionnaire administered to a representative sample of students who took the university entrance examination (PEvAU, its Spanish acronym) in Spanish North Africa. A quantitative research design was adopted in which multivariate analysis (MANOVA) was applied anda decision tree, which was also used for graphical and analytical analysis. The main results indicated a significant influence of parents on their children’s choices, this being the best predictor regarding the decision to take the said examination. It was also verified that their choice of Spanish Baccalaureate programme was significantly associated with their selected career path, and gender and socioeconomic status had a significant impact on that decision. These results lead to the need for further research on guidance from secondary education onwards. It would be interesting to analyse factors neglected thus far, such as those related to the cultural environment of students.
Determinants of the Perceived Credibility of Rebuttals Concerning Health Misinformation
Authors: Sui Yujia , Zhang Bin
Published: February 2021

Users provide and share information with a broad audience on different forms of social media; however, information accuracy is questionable. Currently, the health information field is severely affected by misinformation. Thus, addressing health misinformation is integral for enhancing public health. This research can help relevant practitioners (i.e., government officials, medical and health service personnel, and educators) find the most effective correctional interventions for governing health misinformation. We constructed a theoretical model for credibility-oriented determinants refuting misinformation based on the elaboration likelihood model. We aggregated 415 pieces of valid data through a questionnaire survey. A partial least squares structural equation model evaluated this research model. The results indicated that both perceived information quality and perceived source credibility can enhance perceived information credibility. Under some circumstances, the influence of information quality on information credibility may be more important than that of the information source. However, the cognitive conflict and knowledge self-confidence of information receivers weaken the influence of information quality on information credibility. In contrast, cognitive conflict can strengthen the influence of source credibility on information credibility. Further, perceived information quality can be affected by information usefulness, understandability, and relevance, while perceived source reliability can be affected by source expertise and authority.
Social Media Use and Adolescents’ Sleep: A Longitudinal Study on the Protective Role of Parental Rules Regarding Internet Use before Sleep
Authors: van den Eijnden Regina J.J.M. , Geurts Suzanne M. , ter Bogt Tom F.M. , van der Rijst Vincent G. , Koning Ina M.
Published: February 2021

The popularity of social media use among adolescents has raised concerns about the potentially harmful effects of social media use on adolescents’ sleep. Since longitudinal research considering this relationship is scarce, the present two-wave longitudinal study of 2021 secondary school students (Mage = 13.86, SD = 1.25) examined whether frequency of social media use and problematic social media use predicted adolescents’ bedtime and quality of sleep. Moreover, the protective role of parental rules regarding Internet and smartphone use one hour before sleep was examined. The findings indicated that strict parental rules about Internet and smartphone use before sleep might prevent negative consequences of social media use on bedtime and sleep quality, but only among less engaged social media users. Once adolescents are highly engaged social media users, strict parental rules do not seem to prevent negative media influences on sleep. This implies that limiting Internet accessibility before bedtime can help prevent adolescents’ sleep problems, but that regulation is less effective for adolescents who are already highly involved in social media use.
Stunting as a Synonym of Social Disadvantage and Poor Parental Education
Authors: Scheffler Christiane , Hermanussen Michael , Soegianto Sugi Deny Pranoto , Homalessy Alexandro Valent , Touw Samuel Yan , Angi Sevany Isabella , Ariyani Queen Sugih , Suryanto Tjahyo , Matulessy Giovanni Kathlix Immanuel , Fransiskus Taolin , Safira Andrea V. Ch. , Puteri Maria Natalia , Rahmani Rani , Ndaparoka Debora Natalia , Payong Maria Kurniati Ester , Indrajati Yohannes Dian , Purba Reynardo Kurnia Hadiyanto , Manubulu Regina Maya , Julia Madarina , Pulungan Aman B.
Published: February 2021

Socially, economically, politically and emotionally (SEPE) disadvantaged children are shorter than children from affluent background. In view of previous work on the lack of association between nutrition and child growth, we performed a study in urban schoolchildren. We measured 723 children (5.83 to 13.83 years); Kupang, Indonesia; three schools with different social background. We investigated anthropometric data, clinical signs of malnutrition, physical fitness, parental education, and household equipment. Subjective self-confidence was assessed by the MacArthur test. The prevalence of stunting was between 8.5% and 46.8%. Clinical signs of under- or malnutrition were absent even in the most underprivileged children. There was no delay in tooth eruption. Underprivileged children are physically fitter than the wealthy. The correlation between height and state of nutrition (BMI_SDS, skinfold_SDS, MUAC_SDS) ranged between r = 0.69 (p < 0.01) and r = 0.43 (p < 0.01) in private school children, and between r = 0.07 (ns) and r = 0.32 (p < 0.01) in the underprivileged children. Maternal education interacted with height in affluent (r = 0.20, p < 0.01) and in underprivileged children (r = 0.20, p < 0.01). The shortness of SEPE disadvantaged children was not associated with anthropometric and clinical signs of malnutrition, nor with delay in physical development. Stunting is a complex phenomenon and may be considered a synonym of social disadvantage and poor parental education.
Training New Doctors in Mozambique. A Sustainable International Aid Health Program
Authors: Romero-Hernández Manuel , Barber Patricia , Clavijo-Sánchez Coraima , López-Rivero Luis
Published: February 2021

The collaborative project between the University of Las Palmas de Gran Canaria and the public University of Mozambique, UniZambeze, aims to strengthen the institutional and training capacities of its Faculty of Medicine located in Tete to provide new medical graduates. The essence of the program, training doctors, has the objective of improving the healthcare system and making it sustainable for the integration of new graduates into the staff of the faculty. In this work, we determine the cost of education for a new doctor and we evaluate the social benefit of the program in terms of the human capital. The program has led to the training of 199 new doctors in the 11 years of operation and is leading the way for 100 more in the next four years. The incorporation of some of them into the faculty’s staff will generate new doctor graduates in the near future with a cost below 6000 EUR each in normal circumstances. These results can help to determine how much traditional international aid healthcare programs can save when investing in the education of new doctors. This program is an alternative policy for the international aid financing budgets of donor countries. Supporting teachers and native doctors in the future with private and public patronage programs can raise the efficiency per EUR spent.
A Systematic Review of Economic Evaluations of Health-Promoting Food Retail-Based Interventions
Authors: Tran Huong Ngoc Quynh , McMahon Emma , Moodie Marj , Ananthapavan Jaithri
Published: February 2021

Background: While the number of retail interventions with impacts on diet- and/or health-related outcomes is increasing, the economic evaluation literature is limited. This review investigated (i) the cost-effectiveness of health-promoting food retail interventions and (ii) key assumptions adopted in these evaluations. Methods: A systematic review of published academic studies was undertaken (CRD42020153763). Fourteen databases were searched. Eligible studies were identified, analysed, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results: Eight studies that evaluated 30 retail interventions were included in the review. Common outcomes reported were cost per healthy food item purchased/served or cost per disability-adjusted life year (DALY) averted. Four studies undertook cost-utility analyses and half of these studies concluded that retail interventions were cost-effective in improving health outcomes. Most studies did not state any assumptions regarding compensatory behaviour (i.e., purchases/consumption of non-intervention foods or food purchases/consumption from non-intervention settings) and presumed that sales data were indicative of consumption. Conclusion: The cost-effectiveness of retail-based health-promoting interventions is inconclusive. Future health-promoting retail interventions should regularly include an economic evaluation which addresses key assumptions related to compensatory behaviour and the use of sales data as a proxy for consumption.
Nursing Lecturers’ Perception and Experience of Teaching Cultural Competence: A European Qualitative Study
Authors: Antón-Solanas Isabel , Huércanos-Esparza Isabel , Hamam-Alcober Nadia , Vanceulebroeck Valérie , Dehaes Shana , Kalkan Indrani , Kömürcü Nuran , Coelho Margarida , Coelho Teresa , Casa-Nova Antonio , Cordeiro Raul , Ramón-Arbués Enrique , Moreno-González Sergio , Tambo-Lizalde Elena
Published: February 2021

Cultural competence is an essential component in providing effective and culturally responsive healthcare services, reducing health inequalities, challenging racism in health care and improving patient safety, satisfaction and health outcomes. It is thus reasonable that undergraduate nursing students can develop cultural competency through education and training. The aim of this paper was to investigate nursing lecturers’ perception and experience of teaching cultural competence in four undergraduate nursing programs. A phenomenological approach was selected to illicit nursing lecturers’ perception of culture and experience of teaching cultural competence. Semi-structured personal interviews were held with a sample of 24 lecturers from four European universities. The anonymized transcripts were analyzed qualitatively following Braun and Clark’s phases for thematic analysis. Six themes and fifteen subthemes emerged from thematic analysis of the transcripts. Cultural competence was not explicitly integrated in the nursing curricula. Instead, the lecturers used mainly examples and case studies to illustrate the theory. The integration of cultural content in the modules was unplanned and not based on a specific model. Nursing programs should be examined to establish how cultural content is integrated in the curricula; clear guidelines and standards for a systematic integration of cultural content in the nursing curriculum should be developed.
A GIS-Based System for Spatial-Temporal Availability Evaluation of the Open Spaces Used as Emergency Shelters: The Case of Victoria, British Columbia, Canada
Authors: Yao Yibing , Zhang Yuyang , Yao Taoyu , Wong Kapo , Tsou Jin Yeu , Zhang Yuanzhi
Published: February 2021

Canadian emergency management planners have historically ignored the self-motivated evacuation procedures of people who cannot initially choose the safest evacuation areas. In densely developed urban areas, open spaces can be seen as ideal evacuation areas and should thus be included in shelter planning. In this study, the public open spaces in Great Victoria were selected as the study area and evaluated using GIS technologies. A multi-criteria TOPSIS evaluation model was used to conduct comprehensive quantitative evaluations of the open spaces’ safety, accessibility, and availability. Through hybrid process, service area, and POI aggregation coupling analyses, a model is created that provides an overall evaluation at the district level. In addition to providing a model for evaluating open spaces as emergency shelters, applicable to most Canadian cities, this study emphasizes the importance and disadvantages of open space emergency shelters in Canada, which have heretofore been ignored by decision makers. In Great Victoria, we found that the distribution of open spaces does not match the dynamics of the population distribution, meaning that through inadequate preparation some districts lack a safe evacuation place—this in an area where people are at high risk of earthquake disasters and their subsequent effects.
Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5
Authors: Heinbockel Lena , Weindl Günther , Correa Wilmar , Brandenburg Julius , Reiling Norbert , Wiesmüller Karl-Heinz , Schürholz Tobias , Gutsmann Thomas , Martinez de Tejada Guillermo , Mauss Karl , Brandenburg Klaus
Published: February 2021

The polypeptide Pep19-2.5 (Aspidasept®) has been described to act efficiently against infection-inducing bacteria by binding and neutralizing their most potent toxins, i.e., lipopolysaccharides (LPS) and lipoproteins/peptides (LP), independent of the resistance status of the bacteria. The mode of action was described to consist of a primary Coulomb/polar interaction of the N-terminal region of Pep19-2.5 with the polar region of the toxins followed by a hydrophobic interaction of the C-terminal region of the peptide with the apolar moiety of the toxins. However, clinical development of Aspidasept as an anti-sepsis drug requires an in-depth characterization of the interaction of the peptide with the constituents of the human immune system and with other therapeutically relevant compounds such as antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). In this contribution, relevant details of primary and secondary pharmacodynamics, off-site targets, and immunogenicity are presented, proving that Pep19-2.5 may be readily applied therapeutically against the deleterious effects of a severe bacterial infection.
Mitochondrial Transcription Termination Factor 27 Is Required for Salt Tolerance in Arabidopsis thaliana
Authors: Jiang Deyuan , Chen Jian , Zhang Zhihong , Hou Xin
Published: February 2021

In plants, mTERF proteins are primarily found in mitochondria and chloroplasts. Studies have identified several mTERF proteins that affect plant development, respond to abiotic stresses, and regulate organellar gene expression, but the functions and underlying mechanisms of plant mTERF proteins remain largely unknown. Here, we investigated the function of Arabidopsis mTERF27 using molecular genetic, cytological, and biochemical approaches. Arabidopsis mTERF27 had four mTERF motifs and was evolutionarily conserved from moss to higher plants. The phenotype of the mTERF27-knockout mutant mterf27 did not differ obviously from that of the wild-type under normal growth conditions but was hypersensitive to salt stress. mTERF27 was localized to the mitochondria, and the transcript levels of some mitochondrion-encoded genes were reduced in the mterf27 mutant. Importantly, loss of mTERF27 function led to developmental defects in the mitochondria under salt stress. Furthermore, mTERF27 formed homomers and directly interacted with multiple organellar RNA editing factor 8 (MORF8). Thus, our results indicated that mTERF27 is likely crucial for mitochondrial development under salt stress, and that this protein may be a member of the protein interaction network regulating mitochondrial gene expression.
Relative Contribution of Proprioceptive and Vestibular Sensory Systems to Locomotion: Opportunities for Discovery in the Age of Molecular Science
Authors: Akay Turgay , Murray Andrew J.
Published: February 2021

Locomotion is a fundamental animal behavior required for survival and has been the subject of neuroscience research for centuries. In terrestrial mammals, the rhythmic and coordinated leg movements during locomotion are controlled by a combination of interconnected neurons in the spinal cord, referred as to the central pattern generator, and sensory feedback from the segmental somatosensory system and supraspinal centers such as the vestibular system. How segmental somatosensory and the vestibular systems work in parallel to enable terrestrial mammals to locomote in a natural environment is still relatively obscure. In this review, we first briefly describe what is known about how the two sensory systems control locomotion and use this information to formulate a hypothesis that the weight of the role of segmental feedback is less important at slower speeds but increases at higher speeds, whereas the weight of the role of vestibular system has the opposite relation. The new avenues presented by the latest developments in molecular sciences using the mouse as the model system allow the direct testing of the hypothesis.
Role, Laboratory Assessment and Clinical Relevance of Fibrin, Factor XIII and Endogenous Fibrinolysis in Arterial and Venous Thrombosis
Authors: Memtsas Vassilios P. , Arachchillage Deepa R. J. , Gorog Diana A.
Published: February 2021

Diseases such as myocardial infarction, ischaemic stroke, peripheral vascular disease and venous thromboembolism are major contributors to morbidity and mortality. Procoagulant, anticoagulant and fibrinolytic pathways are finely regulated in healthy individuals and dysregulated procoagulant, anticoagulant and fibrinolytic pathways lead to arterial and venous thrombosis. In this review article, we discuss the (patho)physiological role and laboratory assessment of fibrin, factor XIII and endogenous fibrinolysis, which are key players in the terminal phase of the coagulation cascade and fibrinolysis. Finally, we present the most up-to-date evidence for their involvement in various disease states and assessment of cardiovascular risk.
CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?
Authors: Fuentes-Baile María , Pérez-Valenciano Elizabeth , García-Morales Pilar , de Juan Romero Camino , Bello-Gil Daniel , Barberá Víctor M. , Rodríguez-Lescure Álvaro , Sanz Jesús M. , Alenda Cristina , Saceda Miguel
Published: February 2021

D-amino acid oxidase (DAAO) is an enzyme that catalyzes the oxidation of D-amino acids generating H2O2. The enzymatic chimera formed by DAAO bound to the choline-binding domain of N-acetylmuramoyl-L-alanine amidase (CLytA) induces cytotoxicity in several pancreatic and colorectal carcinoma and glioblastoma cell models. In the current work, we determined whether the effect of CLytA-DAAO immobilized in magnetic nanoparticles, gold nanoparticles, and alginate capsules offered some advantages as compared to the free CLytA-DAAO. Results indicate that the immobilization of CLytA-DAAO in magnetic nanoparticles increases the stability of the enzyme, extending its time of action. Besides, we compared the effect induced by CLytA-DAAO with the direct addition of hydrogen peroxide, demonstrating that the progressive generation of reactive oxygen species by CLytA-DAAO is more effective in inducing cytotoxicity than the direct addition of H2O2. Furthermore, a pilot study has been initiated in biopsies obtained from pancreatic and colorectal carcinoma and glioblastoma patients to evaluate the expression of the main genes involved in resistance to CLytA-DAAO cytotoxicity. Based on our findings, we propose that CLytA-DAAO immobilized in magnetic nanoparticles could be effective in a high percentage of patients and, therefore, be used as an anti-cancer therapy for pancreatic and colorectal carcinoma and glioblastoma.