bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Legend from Pyrotinib Treatment in Patients With HER2-positive Metastatic Breast Cancer and Brain Metastasis: Exploratory Final Analysis of Real-World, Multicenter Data
Authors: Anwar Munawar , Chen Qitong , Ouyang Dengjie , Wang Shouman , Xie Ning , Ouyang Quchang , Fan Peizhi , Qian Liyuan , Chen Gannong , Zhou Enxiang , Guo Lei , Gu Xiaowen , Ding Boning , Yang Xiaohong , Liu Liping , Deng Chao , Xiao Zhi , Li Jing , Wang Yunqi , Zeng Shan , Hu Jinhui , Zhou Wei , Qiu Bo , Wang Zhongming , Weng Jie , Liu Mingwen , Li Yi , Tang Tiegang , Wang Jianguo , Zhang Hui , Dai Bin , Tang Wuping , Wu Tao , Xiao Maoliang , Li Xiantao , Liu Hailong , Li Lai , Yi Wenjun
Published: October 2024

Supplementary Legend
Supplementary Data from Pharmacodynamic Biomarkers Predictive of Survival Benefit with Lenvatinib in Unresectable Hepatocellular Carcinoma: From the Phase III REFLECT Study
Authors: Finn Richard S. , Kudo Masatoshi , Cheng Ann-Lii , Wyrwicz Lucjan , Ngan Roger K.C. , Blanc Jean-Frederic , Baron Ari D. , Vogel Arndt , Ikeda Masafumi , Piscaglia Fabio , Han Kwang-Hyub , Qin Shukui , Minoshima Yukinori , Kanekiyo Michio , Ren Min , Dairiki Ryo , Tamai Toshiyuki , Dutcus Corina E. , Ikezawa Hiroki , Funahashi Yasuhiro , Evans Thomas R. Jeffry
Published: October 2024

Supplementary appendix, supplementary tables s1 - s9, supplementary figures s1 - s8
Data from Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy
Authors: Bleach Rachel , Madden Stephen F. , Hawley James , Charmsaz Sara , Selli Cigdem , Sheehan Katherine M. , Young Leonie S. , Sims Andrew H. , Souček Pavel , Hill Arnold D. , McIlroy Marie
Published: October 2024

AbstractPurpose:
There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic steroid precursors, acting via the androgen receptor (AR), promote an endocrine-resistant breast cancer phenotype.
Experimental Design:
AR was evaluated in a primary breast cancer tissue microarray (n = 844). Androstenedione (4AD) levels were evaluated in serum samples (n = 42) from hormone receptor–positive, postmenopausal breast cancer. Levels of androgens, progesterone, and estradiol were quantified using LC/MS-MS in serum from age- and grade-matched recurrent and nonrecurrent patients (n = 6) before and after aromatase inhibitor (AI) therapy (>12 months). AR and estrogen receptor (ER) signaling pathway activities were analyzed in two independent AI-treated cohorts.
Results:
AR protein expression was associated with favorable progression-free survival in the total population (Wilcoxon, P < 0.001). Pretherapy serum samples from breast cancer patients showed decreasing levels of 4AD with age only in the nonrecurrent group (P < 0.05). LC/MS-MS analysis of an AI-sensitive and AI-resistant cohort demonstrated the ability to detect altered levels of steroids in serum of patients before and after AI therapy. Transcriptional analysis showed an increased ratio of AR:ER signaling pathway activities in patients failing AI therapy (t test P < 0.05); furthermore, 4AD mediated gene changes associated with acquired AI resistance.
Conclusions:
This study highlights the importance of examining the therapeutic consequences of the steroid microenvironment and demonstrable receptor activation using indicative gene expression signatures.
Table S4 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Authors: Dravillas Caroline E. , Coleman Samuel S. , Hoyd Rebecca , Caryotakis Griffin , Denko Louis , Chan Carlos H.F. , Churchman Michelle L. , Denko Nicholas , Dodd Rebecca D. , Eljilany Islam , Hardikar Sheetal , Husain Marium , Ikeguchi Alexandra P. , Jin Ning , Ma Qin , McCarter Martin D. , Osman Afaf E.G. , Robinson Lary A. , Singer Eric A. , Tinoco Gabriel , Ulrich Cornelia M. , Zakharia Yousef , Spakowicz Daniel , Tarhini Ahmad A. , Tan Aik Choon
Published: October 2024

Modeling results for the microbes enriched in the tumors responsive or not-responsive to immunotherapy
Tópicos de marketing no século XXI: volume 4
Authors:   Universidade de São Paulo. Escola de Artes, Ciências e Humanidades, Reimão Sandra , Miyazaki Silvio Y. M. ,   Universidade de São Paulo. Escola de Artes, Ciências e Humanidades
Published: October 2024

Tópicos de Marketing no século XXI é uma publicação do curso de Marketing da Escola de Artes, Ciências e Humanidades da Universidade de São Paulo, EACH-USP, voltada para difusão de trabalhos da área de marketing em toda sua amplitude, incluindo suas interfaces com comunicação, administração, publicidade, propaganda, gestão, psicologia, sociologia, entre outras. Tópicos de Marketing no século XXI é uma publicação eletrônica disponibilizada em acesso aberto.
Kremlinism: Russia's Malign Civilizational Force
Authors:   Black Trident LLC, Roslycky Lada , Liubovets Hryhorii , Korol Valerii
Published: October 2024

This article considers Russian aggression against Ukraine within the context of a global clash between malign anti-civilizational forces and civilization. It posits that today’s world situation should be understood as one positioned on a civilizational fault line. The conflict between these two dynamics is a key feature of the 21st century. The contemporary global terror stemming from the genocide of the Ukrainian people is linked to the growing phenomenon of the “new enemies of totalitarian Russia.” This situation puts individuals and states worldwide at risk. Moscow’s ambitions are not limited locally, regionally, or geographically; they are already impacting the peaceful future of the planet and its existence. The terms Kremlinism, Ruscism, and Putinism are introduced as manifestations of the Kremlin’s traditional fascism, which is central to Moscow’s anti-civilizational force. The authors analyze Russia’s internal and international use of rhetoric and lawfare. While the Kremlin may be effective in frightening or fooling leaders of democracies, its own citizens are the primary targets of its terrorist efforts. The objective is to demonstrate that a global response is required from civilized citizens and states. This response must outline a favorable vision of a future world where civilization thrives and confidently overcomes the forces of autocracy, authoritarianism, and corruption.
The Impact of the Russian-Ukrainian Hybrid War on the European Union's Cybersecurity Policies and Regulations
Authors:   Széchenyi István University, Kelemen Roland
Published: October 2024

While Russia transitioned from hybrid to conventional warfare in Ukraine, NATO recognized cyberspace as another domain where allied response can be invoked. The European Union also decided to enhance the cybersecurity capabilities of the organization and its member states, making social resilience a priority area. It is recognized that the security of cyberspace and related systems is not just an economic issue but one that affects the whole society, necessitating a more complex strategy and regulation. The EU has taken steps to mitigate the cyber risks associated with hybrid warfare, enhancing network and cognitive security. However, offensive cyber operations could increasingly lead to open armed conflict. During existing conflicts, some cyber operations may undermine public confidence and further escalate the situation. The EU and its Member States must pay closer attention to escalation dynamics in their legislation and practices. It is crucial to scrutinize cyber policies, set specific targets and deadlines, and regularly update them. This will require stakeholders to find the appropriate regulatory levels and align national regulations, practices, and standards.
Hildenbrandia ardreae sp. nov. (Rhodophyta), recorded before as Hildenbrandia dawsonii (nom. inval.)
Authors: PEDROCHE FRANCISCO F.
Published: October 2024

Four species of the red algal genus Hildenbrandia have been recorded from Pacific Mexico: H. dawsonii reported on the west coast of Baja California and Jalisco; H. occidentalis with one record from the west coast of Baja California; H. prototypus occurring all along the coast, including the Gulf of California; and the most common and abundant species, H. rubra from Pacific Baja California to Oaxaca, in tropical Pacific Mexico. All four species have been studied morphologically and molecularly using representative specimens. The molecular status regarding the phylogenetic position of H. dawsonii in relation to other species is unclear. H. dawsonii nomenclatural status was analyzed, and additional material from the University Herbaria at UC-Berkekley (UC) was reviewed. Hildenbrandia dawsonii is an invalid name because its alleged basionym (Hildenbrandia canariensis var. dawsonii) is invalid. Therefore, a new species is described: Hildenbrandia ardreae sp. nov., selecting a Dawson specimen from Punta Norte, Cedros Island, Baja California, as the holotype. Furthermore, morphological characters, once used as diagnostic at the species level, are considered irrelevant. The new holotype proposed in this study shows the same characteristics stated by F. Ardré in her original publication (1959) and could be a potential source for DNA extraction for comparative studies.
Asplenium sylvestre: a new name for Asplenium sylvaticum (Polypodiales: Aspleniaceae)
Authors: ARANA MARCELO D. , GANEM ALEJANDRA , LUNA MARÏA LUJAN
Published: October 2024

N/A
The genus Siderus (Lepidoptera: Lycaenidae) in French Guiana: four newly discovered species and conspicuous male genitalia polymorphism
Authors: FAYNEL CHRISTOPHE , FÅHRAEUS CHRISTER , RAMIREZ JUAN-JOSE , ROBBINS ROBERT K.
Published: October 2024

The species of Siderus Kaye present in French Guiana are listed and detailed with notes on male territorial behavior and the plants at which adults feed. In total, seven species were recorded: Siderus leucophaeus (Hübner); Siderus parvinotus Kaye (first record from French Guiana); Siderus athymbra (Hewitson); Siderus diringeri Faynel, Robbins & Fåhraeus sp. nov.; Siderus bisignatus Faynel, Ramírez & Robbins sp. nov.; Siderus castelain Faynel, Fåhraeus & Robbins sp. nov. and Siderus toussaint Faynel, Robbins & Fåhraeus sp. nov. A preliminary delimitation of the genus Siderus is proposed. Description, distribution, detailed illustrations of adults and male genitalia (and some female) are provided for each new species.
A new species of the genus Notodoma Lacordaire, 1854 (Coleoptera, Histeridae, Exosternini) from Korea, with a revised key to species of the genus
Authors: SEUNG JINBAE , LEE SEUNGHYUN , LEE MINHYEUK , LEE SEUNGHWAN
Published: October 2024

A new species of the genus Notodoma Lacordaire, 1854 (Coleoptera, Histeridae, Exosternini), Notodoma koreanum sp. nov., is described from Korea. Most of them recognized from various fungi colonies, feeding on small insect eggs or larvae, as well as fungi. We present the descriptions and images of diagnostic characters for Korean Notodoma species, including Notodoma fungorum Lewis, 1884. Additionally, a revised key to all seven species of the genus Notodoma worldwide, including the newly described species, is provided.
Two new species of Anax Leach, 1815 from the Solomon Islands and Tonga (Odonata: Aeshnidae)
Authors: THEISCHINGER GÜNTHER , KALNINS MARTINS , MARINOV MILEN
Published: October 2024

Species of the cosmopolitan genus Anax Leach, 1815 are among the largest dragonflies and the most powerful flyers. Within the genus the proportion between body length and wing and the body shape of both sexes are of great taxonomic importance. Here we describe two new Anax species: Anax insulanus sp. nov., from the Solomon Islands and A. tonga sp. nov., from Tonga. To distinguish both species from a very similar sympatric congener we compare the S3 Index which is defined as the relative length and width at its narrowest point of abdominal segment 3. Anax fumosus celebense Lieftinck, 1942 is raised to species level. Diagnostic characters of male and female (if available) are illustrated. A key is presented for the identification of the males of the 14 species of Anax known to occur in the Australian, the Oceanian and the south of the Indomalayan Biogeographical Realms.
Contribution to the Chinese subfamily Rhaphidophorinae Walker, 1869 (Orthoptera: Rhaphidophoridae: Rhaphidophorinae) VIII: Three new species of Sinorhaphidophora from Hainan Province
Authors: BIAN XUN
Published: October 2024

In this paper, I report three new species of Sinorhaphidophora based on newly obtained material from Hainan Province, namely: Sinorhaphidophora longiproceris sp. nov., Sinorhaphidophora gracilenta sp. nov. and Sinorhaphidophora minor sp. nov.. In addition, morphological illustrations of Sinorhaphidophora hainanensis (Bian & Shi, 2016) are provided. All the specimens are deposited in Guangxi Normal University.
Excellent thermal, moisture-permeable weft-knitted fabric with core-sheath yarn structure for foot protection in cold environments
Authors: Song Wenxiang , Ma Xiaotao , Ma Pibo
Published: October 2024

In extremely cold environments, maintaining body temperature and reducing heat dissipation is essential for maintaining human health and life safety, but the field of thermal insulation shoe upper fabric has not been deeply studied. In this paper, based on the dual-scale structure of the yarn and shoe upper fabric, a composite yarn with a core-sheath structure is designed, and a using plating stitch pattern weft-knitted whole garment thermal insulation shoe upper fabric with double-layer structure is proposed. By testing the mechanical properties and thermal and moisture performance of the shoe upper fabric and the thermal insulation performance of the whole shoe, the thermal insulation mechanism of the weft-knitted whole garment shoe upper fabric with a double-layer structure and dual-scale structure design was systematically studied. The results show that the shoes made of polyimide/hollow polyester composite yarn with core-sheath structure yarn have good thermal insulation performance. The use of core-sheath yarns can improve the thermal insulation performance of the shoe, and, with the increase of the ratio of core-sheath yarn, the thermal insulation performance of the shoe is better. Starting from the dual-scale shoe fabric structure, this article proposes a novel method for the industrial production of thermal insulation shoe upper fabrics, which is expected to provide guidance for the further development of thermal insulation shoe upper fabric in the future.
Study on vehicle state and tire–road friction coefficient estimation based on maximum correntropy generalized high-degree cubature Kalman filter
Authors: Chen Qiping , Yu Binghao , Zhong Chengping , Jiang Zhiqiang , You Daoliang , Cai Yuanhao
Published: October 2024

To cope with the challenges of inadequate precision and weak robustness of tire–road friction coefficient (TRFC) and vehicle state estimation under mixed Gaussian noise circumstances, this research puts forward a method combining maximum correntropy criterion (MCC) and generalized high-degree cubature Kalman filter (GHCKF). A coupled lateral and longitudinal vehicle model and the Dugoff tire model are established. The vehicle mass is estimated using the recursive least squares approach based on a forgetting factor (FFRLS). Low-cost onboard sensors are utilized to design observers for vehicle state and TRFC. The observers’ effectiveness is tested by Carsim/Simulink co-simulation tests under the conditions of sine steering input and steering wheel angle step input. The research results indicate that in handling mixed Gaussian noise environments, maximum correntropy generalized high-degree cubature Kalman filter (MCGHCKF) method outperforms maximum correntropy cubature Kalman filter (MCCKF), GHCKF, and cubature Kalman filter (CKF) methods concerning robustness and estimation accuracy, providing stable and reliable support for systems of vehicle active safety control.
Justice Matters: Equality-Efficiency Tradeoff in Principles of Macroeconomics
Authors: Vechsuruck Tanadej
Published: October 2024

Students who are trained in standard macroeconomics often prioritize economic efficiency over other values, such as justice. Most of them believe that to achieve higher efficiency, a society needs to sacrifice economic justice. In other words, there exists a tradeoff between equality and efficiency. In my Principles of Macroeconomics class, I therefore create lectures and assignments including self-reflections and group discussions to persuade students to question the value of economic efficiency and justice. The assignments raise the awareness of students about economic justice as another essential value in society. The goal is to encourage students to rethink macroeconomic policies critically, reevaluate their moral biases, and cultivate their moral compass when dealing with ethical dilemmas.

JEL Classification: A22, B0, D63, E0
Proposed Classification of Syndesmotic Soft Tissue Impingement and Its Association With Lateral Talar Cartilage Lesions
Authors: Yoon Yeo Kwon , Park Kwang Hwan , Shim Dong Woo , Lee Wonwoo , Jang Chul-Young , Lee Jin Woo , Han Seung Hwan
Published: October 2024

Background:

Syndesmotic impingement syndrome has been described to explain persistent lateral or anterolateral ankle pain. This condition is thought to often result from a rotational ankle injury. This study aimed to identify the type of syndesmotic impingement tissue according to arthroscopic and histologic findings and to analyze its association with lateral talar cartilage lesions.

Methods:

This retrospective study included 107 ankles in 105 patients who underwent arthroscopic surgery for syndesmotic impingement syndrome from January 2017 to August 2019. Histologic findings of biopsied impingement tissue were obtained in 59 ankles (55.1%) and compared with gross findings on arthroscopy. Cartilage lesions were evaluated using the International Cartilage Repair Society grading system. Risk factors associated with lateral talar cartilage injury were evaluated using multivariate logistic regression analysis.

Results:

Based on the histologic results, the most common pathology was fibrosis (24 ankles [22.4%]), followed by fatty degeneration (23 ankles [21.5%]), synovial hyperplasia (8 ankles [7.5%]), and inflammatory synovium (4 ankles [3.7%]). Interclass correlation coefficient was 0.841 ( P = .001) between histologic results and arthroscopic findings. Patients with fibrotic impingement tissue had on average a significantly longer duration of symptoms (12 vs 48 months, P = .021). A lateral talar dome cartilage lesion was detected in 25 ankles (23.4%). Fibrotic impingement tissue was the only factor significantly associated with lateral talar dome lesion on multivariate logistic regression analysis (odds ratio 10.04; 95% CI 1.84-54.9; P = .008)

Conclusion:

Syndesmotic impingement with fibrotic tissue was often associated with cartilage lesions at the lateral talar dome. Patients with prolonged anterolateral or lateral ankle pain after a rotational ankle injury warrant careful assessment for possible syndesmotic impingement by fibrotic tissue and associated lateral talar cartilage injury.
Bracing for the Storm: A Case Study on Hurricane Preparedness in Higher Education Institutions
Authors: Foster Holly Ann , Thomas James W , Hall Kaitlyn
Published: October 2024

This case is for use in graduate courses in higher education and student affairs administration. It presents a multitude of challenges faced by higher education professionals in the event of a natural disaster. While intensive planning prior to the disaster can help mitigate some of the aftereffects, there will still be a number of decisions that must be made to ensure the safety and security of students, faculty, and staff. This case highlights the complex issues that administrators must often face as well as provides an opportunity to evaluate the complex issues from a variety of perspectives.
Intimate partner violence, women’s health, and rights in the Philippines
Authors: Alibudbud Rowalt
Published: October 2024

In a recent article, Mercier et al. explored the use of innovative technologies, such as telemedicine, for intimate partner violence victims. They emphasized that these technological advancements can increase the comfort, convenience, and time efficiency of healthcare services for intimate partner violence victims. In addition to these technological advancements, this article advocates for addressing structural barriers and upholding the rights of intimate partner violence victims as crucial steps for enhancing their well-being, using the context of women in the Philippines as an illustrative example.
Exploring the Mechanism of Cytotoxic Activity of β-Caryophyllene Oxide and its Potential to Enhance the Activity of Doxorubicin
Authors: Helal Muath , Jaradat Nidal
Published: October 2024

Plant-derived compounds, including flavonoids, sesquiterpenes, and others, have been widely investigated for their role in cancer treatment. Here, we highlight the significance of some natural compounds (β-caryophyllene oxide) in enhancing doxorubicin's chemotherapeutic cytotoxicity. We also determined a novel mechanism of cytotoxicity for β-caryophyllene oxide by revealing its ability to bind with the DNA. This potentially causes its cytotoxicity when added alone and its ability to enhance doxorubicin's cytotoxicity. We also show that some natural compounds (epicatechin) may provide protection to cancer cells against doxorubicin's toxicity. This is most likely caused by their antioxidant behavior which potentially suppressed the doxorubicin-induced reactive oxygen species (ROS) resulting in a decrease in its cytotoxicity. Moreover, similar suppression in the cytotoxicity of β-caryophyllene oxide was noticed when incubated with the other flavonoids.
How I use Maintenance Therapy in Acute Myeloid Leukemia
Authors: Roboz Gail J. , Canaani Jonathan
Published: October 2024

Outcomes for acute myeloid leukemia have improved significantly in the last decade with the approval of novel therapeutics targeting diverse vulnerabilities of leukemic cells, expanded access to stem cell transplantation, and improved safety of transplantation. While attainment of initial remission is now an expected outcome in most AML patients receiving intensive or non-intensive induction regimens, maintaining long-term remission and decreasing the risk of relapse remain critical challenges. Maintenance approaches employing assorted agents have yielded variable success and only recently have been integrated to the standard of care. We present four commonly encountered clinical scenarios that highlight challenges facing physicians as they care for AML patients in remission and contemplate using post-remission maintenance. Using published studies and emerging clinical data, we discuss our approach to maintenance treatment in AML, emphasizing that selection of a specific strategy is an individualized decision based on leukemia biology and risk stratification, presence of targetable mutations, initial treatment approach, performance status, and feasibility of allogeneic stem cell transplantation.
Association between the presence of CRISPR-Cas system genes and antibiotic resistance in Klebsiella pneumoniae isolated from patients admitted in Ahvaz teaching hospitals
Authors: Montazeri Effat Abbasi , Saki Morteza , Savari Mohammad , Meghdadi Hossein , Akrami Sousan
Published: October 2024

Background

This study aims to investigate the frequency of cas1 and cas3 and CRISPR1,2,3 genes in Klebsiella pneumoniae isolates, as well as their connection with antibiotic resistance.

Materials and methods

106 K. pneumoniae isolates were identified by biochemical assays and PCR. The susceptibility to antibiotics was determined by Kirby–Bauer disk diffusion method. Screening of ESBLs was undertaken by using double disk diffusion and standard disk diffusion methods. The E-test and mCIM techniques was used to confirm the disc diffusion-based carbapenem resistance profiles. CRISPR-Cas system genes were identified using PCR.

Results

ESBL production was found in 19% of isolates. Carbapenemase production was found in 46% of the isolates. Furthermore, the bacteria were classified as multidrug (76%), extensively drug-resistant (4%), or pan-drug-resistant (2%). When CRISPR/Cas systems were present, antibiotic resistance was lower; conversely, when they were absent, resistance was higher.

Conclusions

If the CRISPR/Cas modules aren’t present, the bacteria can still acquire foreign DNA, including antibiotic resistance genes. K. pneumoniae isolates with a CRISPR-Cas system were less likely to carry antibiotic-resistance genes than those lacking this defense system.
Understanding and training for the impact of large language models and artificial intelligence in healthcare practice: a narrative review
Authors: McCoy Liam G. , Ci Ng Faye Yu , Sauer Christopher M. , Yap Legaspi Katelyn Edelwina , Jain Bhav , Gallifant Jack , McClurkin Michael , Hammond Alessandro , Goode Deirdre , Gichoya Judy , Celi Leo Anthony
Published: October 2024

Reports of Large Language Models (LLMs) passing board examinations have spurred medical enthusiasm for their clinical integration. Through a narrative review, we reflect upon the skill shifts necessary for clinicians to succeed in an LLM-enabled world, achieving benefits while minimizing risks. We suggest how medical education must evolve to prepare clinicians capable of navigating human-AI systems.
International medical students’ experiences of psychological safety in feedback episodes: a focused ethnographic study
Authors: Thomas Carolyn , Gupta Shalini
Published: October 2024

Background

Feedback and psychological safety are well-established concepts within medical education, vital for student learning and progress. However, the concepts remain unexplored in the context of international students. This area deserves attention given the unique challenges faced by the overseas medical students due to cultural differences. The present study examines international students’ experiences of psychological safety in feedback interactions in a Scottish undergraduate medical programme.

Methods

A focused ethnographic approach was adopted to explore international students’ experiences and perceptions of psychological safety in their feedback experiences. Data were collected in the form of field observations and semi-structured interviews, involving both student and faculty participants. Approximately 13hrs of fieldwork and a total of 11 interviews were conducted. These were analysed using a combination of inductive and deductive thematic analysis.

Results

Data analysis identified four key themes: feedback delivery, educator attributes, cultural factors and longitudinal educational relationships. Both staff and student participants highlighted how environmental factors such as room design and group size functioned as enablers or barriers to psychological safety in feedback episodes. Additionally, students appreciated tutors who expressed vulnerability and demonstrated awareness of their cultural backgrounds. Students described significant differences between the feedback approaches in the host (UK) institute and that in their home country. Longitudinal associations fostered trust and familiarity with peers and tutors, enhancing students’ receptivity to learning and feedback.

Conclusion

This present study highlights cultural differences in feedback practices across countries and their impact on psychological safety among international students. It stresses the importance of integrating overseas students by considering group dynamics, environment and diverse student needs. Staff awareness of cultural variability, openness to tutor vulnerability and fostering long-term educational relationships can greatly enhance psychological safety in learning and teaching activities. These insights are relevant amidst the growing globalisation of medical education and the mobility of students across borders, advocating for tailored integration to optimise their learning experience and achievement.
The significance of a dialectical approach to enrich health professions education
Authors: de Ruiter M. C. , van Klaveren L.-M. , Geukers V. G. M.
Published: October 2024

The Lancet Global Independent Commission has called for a systems-based approach to health professions education. They emphasised the acquisition of collaborative skills, critical reasoning and ethical conduct to prepare students for interprofessional collaborative practice (IPCP). Interprofessional education (IPE) has been put forward as a promising strategy. However, despite the global efforts to incorporate IPE in health professions education curricula, the evidence for a positive impact on IPCP is still inconclusive. This may be related to the misalignment between competency-driven IPE programs that focus on end-stage professional competence and the non-linear development of students’ competence that is necessary for the dynamical nature of IPCP. Therefore, we argue that health professions education, and IPE in particular, needs to incorporate these dynamical processes including social and organization sensitivity. We present a conceptual framework that integrates the Cultural-Historical Theory, the principles of dialectical thinking and the concept of metastable attunement. While dialectical thinking is the ability to perceive the complexity of a dynamic reality that is in a state of constant transition, metastable attunement refers to the consequent adjustment to it. The subsequent instructional design employs a dialectical approach to teaching and learning, based on mediating activities and dialectical inquiry. To reach the full potential of this approach, the mediating activities should ensure a continuum of learning across the curriculum. In addition, faculty development needs to focus on the principles of dialectical inquiry as a pedagogy to optimally guide students. Further research into the extent to which healthcare professionals and students think dialectically may inform improvements to the proposed instructional design, the structure of the learning continuum and the essential requirements for faculty development.
Navigating HIV research among criminalized gender minority populations in Uganda: qualitative insights and lessons learned from novice researchers
Authors: Muwanguzi Patience A. , Nabunya Racheal , Ngabirano Tom D.
Published: October 2024

Background

Transgender individuals often face stigma, discrimination, and various forms of abuse, which negatively impact their mental and physical health. They face a significantly greater risk of HIV, with a higher prevalence than the general population. Despite these challenges, transgender people have limited access to healthcare due to violence, legal barriers, and societal stigma, further exacerbated in countries like Uganda, where transgender identities are criminalized. Therefore, this study explored the lived experiences of HIV researchers working with gender minority populations in criminalizing contexts.

Methods

This was an interpretative phenomenological analysis (IPA) qualitative study. Twelve (12) research team members at all levels were involved in the study. Participants had less than five years of involvement in HIV research among gender minority populations. Data were collected using field notes, reflective journals, documentation from daily team debriefing sessions, and semi-structured interviews. The analysis used NVivo software.

Results

Positive experiences, barriers, and challenges were captured. The positive experiences were ‘respecting cultural diversity’, ‘expanding networks’, ‘addressing misconceptions’ and ‘finding allies’. The barriers included ‘experiencing stigma’, ‘lengthy research processes’, ‘feeling isolated’, ‘fearing for personal safety’, ‘unexpected logistical costs’, and ‘criminalization of sexual and gender minorities’. The key themes that emerged from the lessons learned were: ‘dealing with gatekeepers’, ‘diversity and sensitivity training’, ‘leveraging networks’, ’meaningful community engagement’, ‘reflexivity’, ‘ensuring safety’, ‘equal partnership’, ‘giving feedback’ and ‘awareness of legal implications’.

Conclusions

This study highlights the importance of cultural sensitivity, community engagement, and reflexivity in research design and implementation. The findings emphasize the need for innovative strategies to navigate legal, social, and logistical barriers that researchers and participants face. Despite these challenges, the study demonstrates that meaningful collaboration with community members and building trust can significantly enhance the research process and outcomes. Future research should continue to explore these strategies while addressing ethical and safety concerns.
APC mutations dysregulate alternative polyadenylation in cancer
Authors: Gabel Austin M. , Belleville Andrea E. , Thomas James D. , Pineda Jose Mario Bello , Bradley Robert K.
Published: October 2024

Background

Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood.

Results

We describe an unbiased analysis of molecular regulators of poly(A) site selection across The Cancer Genome Atlas and identify that colorectal adenocarcinoma is an outlier relative to all other cancer subtypes. This distinction arises from the frequent presence of loss-of-function APC mutations in colorectal adenocarcinoma, which are strongly associated with long 3′ UTR expression relative to tumors lacking APC mutations. APC knockout similarly dysregulates APA in human colon organoids. By mining previously published APC eCLIP data, we show that APC preferentially binds G- and C-rich motifs just upstream of proximal poly(A) sites. Lastly, we find that reduced APC expression is associated with APA dysregulation in tumor types lacking recurrent APC mutations.

Conclusions

As APC has been previously identified as an RNA-binding protein that preferentially binds 3′ UTRs during mouse neurogenesis, our results suggest that APC promotes proximal poly(A) site use and that APC loss and altered expression contribute to pervasive APA dysregulation in cancers.
Active suicidal ideation in an adolescent with autism spectrum disorder receiving methylphenidate: a case report
Authors: Kerkeni Ali , Pons Charles Olivier
Published: October 2024

Background

Methylphenidate is a psychostimulant treatment widely prescribed in children and adolescents with attention deficit hyperactivity disorder. Although published studies are reassuring regarding the safety and tolerability of this treatment in the short and long term, there are case studies that have reported the possibility of serious adverse effects following methylphenidate initiation in children and adolescents.

Case presentation

In the present study, we illustrate the case of a 13-year-old adolescent, who was diagnosed with autism spectrum disorder, attention deficit hyperactivity disorder, and other psychiatric comorbidities. The patient developed active suicidal ideation a few weeks after initiating methylphenidate. He also presented irritability accentuation, insomnia, decreased appetite, and an increase in temper tantrums after initiation of this treatment. Psychiatric evaluation, according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), did not reveal major psychiatric disorders that could explain them, particularly mood disorders. The risk of suicide was assessed as high indicating a hospitalization and the immediate discontinuation of this treatment. The evolution was marked by a disappearance of suicidal thoughts 2 days after discontinuation of methylphenidate and a clear decrease in symptoms of poor tolerance. The authors were unable to establish a cause-and-effect link between the prescription of methylphenidate and the appearance of suicidal thoughts in this patient, but the results of studies already published seem to provide clues that could explain this link.

Conclusions

The purpose of this work is to alert clinicians to the possibility that young people who have multiple neurodevelopmental disorders may experience suicidal thoughts after starting methylphenidate even in the absence of  mood disorders. The link between the prescription of this treatment and the onset of suicidal ideation is not as clear and requires more controlled studies. This suggests particular attention, such as informing the young people and their families beforehand and planning rigorous psychiatric evaluations after the prescription.
NeRSI: Neural implicit representations for 5D seismic data interpolation
Authors: Gao Wenbin , Liu Dawei , Chen Wenchao , Sacchi Mauricio D. , Wang Xiaokai
Published: October 2024

Due to challenging field operations and resource constraints, seismic data acquisition often requires coping with missing traces. Interpolation algorithms are crucial for reconstructing these missing traces to enable improved subsurface analysis and interpretation. Although deep learning has made exciting advances in seismic reconstruction, its focus has predominantly been on 2D and 3D data sets with relatively low rates of missing data. Reconstruction of 5D seismic data entails considering simultaneous sources and receivers deployed in areal arrays to solve the reconstruction problem. The latter offers greater data redundancy, which can be leveraged to enhance interpolation quality. Traditional 5D deep-learning interpolation methods rely heavily on synthetic training pairs, posing challenges when applied to real-world data. This necessitates transfer learning techniques, which can be cumbersome. To address this, we introduce a self-supervised, coordinate-based deep interpolation algorithm that mitigates the need for labeled data. Using a multilayer perceptron (MLP) network can effectively encode the continuous seismic 5D wavefield. Once trained, the MLP can infer missing trace amplitudes from their coordinates. We contribute to boosting the MLP, enabling it to generate seismic profiles rather than single-point predictions. This enhancement significantly strengthens the model’s performance and efficiency. Moreover, we apply nuclear norm regularization to the output profiles, improving the reconstruction quality. The effectiveness of our algorithm is illustrated with synthetic and field data experiments.
Phase II Trial of Adjuvant S-1 Following Neoadjuvant Chemotherapy and Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: The PIECE Trial
Authors: Nomura Motoo , Yamaguchi Toshifumi , Chin Keisho , Hato Shinji , Kato Ken , Baba Eishi , Matsubara Hisahiro , Mukaida Hidenori , Yoshii Takako , Tsuda Masahiro , Tsubosa Yasuhiro , Kitagawa Yuko , Oze Isao , Ishikawa Hideki , Muto Manabu
Published: October 2024

Background

Neoadjuvant chemotherapy followed by surgery (NAC-S) is the standard therapy for locally advanced esophageal squamous cell carcinoma (ESCC) in Japan.

Objective

The aim of this phase II trial was to assess the efficacy and safety of the addition of adjuvant S-1 after R0 resection in ESCC patients who received NAC-S.

Patients and methods

Key eligibility criteria included clinical stage IB–III (without T4 disease) ESCC, age 20–75 years, and an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Patients received adjuvant therapy with four cycles of S-1 (80 mg/m2/day) administered orally for 4 weeks of 6-week cycles. The primary endpoint was 3 year relapse-free survival (RFS). If the lower confidence limit for 3 year RFS was >50%, we judged that the primary endpoint of this study was met.

Results

A total of 52 patients were enrolled between January 2016 and January 2019. Two patients were excluded from analysis; five patients were determined to have R1 or R2 resection, and seven patients did not receive adjuvant S-1. The 3-year RFS and overall survival rates in the intention-to-treat population were 72.3% (90% confidence interval [CI] 59.9–81.5) and 85.0% (90% CI 73.9–91.6), indicating that the primary endpoint was met. Grade ≥3 adverse events with an incidence ≥10% included neutropenia (13.2%), anorexia (13.2%), and diarrhea (10.5%). There were no treatment-related deaths.

Conclusion

Adjuvant S-1 after NAC-S showed promising efficacy with a manageable safety profile for patients with resectable ESCC and warrants further evaluation in larger studies.
More Than Just Another Elbow Tendinopathy: A Case Series of Misdiagnosed Ulnar Nerve Compression and Review of Common Upper Extremity Misdiagnoses in Climbing
Authors: Meller Leo L.T. , Allen Matthew R. , Sigua Logan H. , Hooper Jason , Vitale Kenneth
Published: October 2024

Climbing is an increasingly popular sport. Yet, we have encountered numerous misdiagnosed climbing injuries, highlighting a gap in climbing-related literature and a need for heightened awareness within the sports medicine community. We present a case series that highlights the clinical manifestation of ulnar nerve entrapment and compression in three patients with initially misdiagnosed and mismanaged elbow tendinopathy. After a correct diagnosis of ulnar nerve pathology was made, each patient underwent a prescribed rehabilitation protocol that focused on nerve motility exercises (tensioning and flossing), resulting in a significant reduction in pain and a successful return to their pre-injury climbing performance. We thus aim to raise awareness of this often-mistreated presentation. Furthermore, we highlight other common upper extremity climbing misdiagnoses and provide relevant clinical recommendations to accurately identify and manage such injuries in climbers.
Is there something that connects the diversity of historical narratives?
Authors: Nordgren Kenneth
Published: October 2024

The interview with Kenneth Nordgren from Karlstad University, Sweden, addresses key questions about transcultural dialogue, the role of historical thinking, and the challenges of teaching history. The starting point is the question of how transcultural dialogue and historical thinking have changed in recent years from the perspective of the interviewee. The interview also discusses how transcultural academic exchange can be promoted, taking into account different educational contexts and social values. It further considers how to ensure that the academic debate is not dominated only by socially or economically privileged groups. Other topics include the role of digitalisation and online communities in history education, and the benefits of cross-disciplinary approaches. The extent to which current global challenges such as pandemics, wars and climate change underline the need for increased transcultural exchange in history education will also be addressed.
Analysis of the Russian Financial Market Indicators
Authors: Yudina O.
Published: October 2024

The financial market is a key factor in economic development, an important tool for the redistribution and transformation of investment resources, as well as a litmus test of the state's economic health. The peculiarity of the Russian financial market is its "youth" and "inexperience" in comparison with the markets of developed economies, the path of trial and error, inconsistency in the context of the uniqueness of the financial system of the Russian Federation. This market is particularly vulnerable and volatile in the face of sanctions and global economic turmoil, so it needs competent targeting guidance, effective tools and verified coordination methods and techniques. The fundamental problems of the Russian financial market are quite deep and do not always appear on the surface, which requires an in-depth and permanent tactical and strategic analysis of factors, causes, trends, trends and indicators that can correct the situation in a timely manner in any economic scenario in manual management. The article examines the main features, rallies, features and directions of the development of the financial market of the Russian Federation at the present stage. The analysis of the issuer's statements for 2005–2023, dividend payments for the same period is presented, the dynamics of growth of the segment of mutual funds and exchange-traded mutual funds is considered. A comparative structure of household financial assets in 2017 and 2023 is proposed, the share of different organizational and legal forms of joint-stock companies in the total number of joint-stock companies in 2019–2023, the share of different groups of banks in the value of assets of the Russian banking system in 2000–2023 is given.

The final results of the study substantiate the importance of the role of the state as a regulator of the stock market, emphasize its Russian functions, and highlight its conceptual problems. The research is based on the analysis of foreign and Russian publications, as well as on statistical conclusions of financial and statistical data.
Factors Determining the Need to Improve the Training System for Sports Managers in the Tula Region
Authors: Dudchenko P. , Shishkin Andrey
Published: October 2024

The article presents the main factors determining the need to improve the system of training sports managers. The determining factors we noted were: multi-departmental management structure of the sphere of physical culture and sports, features of management of commercial and budgetary sports organizations, business sphere and marketing, types and methods of providing services, personnel training system, sports industry, construction and operation of physical education, recreation and sports facilities. The active development of the sphere of physical culture and sports in the Tula region requires the rapid provision of this sphere with highly qualified personnel; we have put forward an assumption about solving this problem. In our opinion, the creation of a student-run sports organization on the basis of a university will increase the efficiency of mastering the competencies of a sports manager.
The Development of the Enterprise Invest Strategy for In-Depth Ethylbenzene Processing Purposes
Authors: Kizimov M.
Published: October 2024

The article is dedicated to the forming questions of the complex invest program of the large industrial enterprise, which activity covers several technological conversions. The vertical industrial chaining is suggested as the invest planning priority, directed to the biggest diversification and the steady raw material supply.