bluuebunny/crossref_metadata_2025 huggingface dataset:
AN UPDATED CHECKLIST AND KEY TO THE SPECIES OF BOLIVIAN BEGONIA, INCLUDING ONE NEW SPECIES
Authors: Moonlight Peter , Fuentes Alfredo F.
Published: August 2022

Bolivian Begonia are among the most poorly studied of American begonias. We provide here a checklist and key to the Bolivian Begonia flora, which currently includes ten sections, 43 species, three subspecies and three varieties. We also fully discuss the nomenclature and typification of all Bolivian Begonia species and designate 16 lectotypes. We describe and provide an illustration of one new species and provide emended descriptions for eight species. We have assessed six species for extinction risk under IUCN Red List criteria and provide four new synonyms. We compare our checklist with previous treatments of Bolivian Begonia and discuss all changes in detail.
Las begonias de Bolivia se encuentran entre las begonias americanas menos estudiadas. Proporcionamos una lista de verificación y una clave para la flora de begonias de Bolivia, que actualmente incluye diez secciones, 43 especies, tres subespecies y tres variedades. También proporcionamos una discusión completa de la nomenclatura y tipificación de todas las especies bolivianas de Begonia y designamos 16 lectotipos.  Describimos e ilustramos una nueva especie y adicionamos descripciones corregidas para ocho especies. Evaluamos seis especies en riesgo de extinción según los criterios de la lista roja de la UICN y proponemos cuatro nuevos sinónimos. Comparamos nuestra lista de verificación con tratamientos anteriores sobre las begonias bolivianas y discutimos todos los cambios en detalle.
Управление рисками реализации инвестиционных строительных проектов в области безопасности и охраны труда
Authors: Агошков А.И. , Курочкин П.А. , Артамонова А.А. , Шамин Д.В. , Паночкина Л.В.
Published: August 2022

В монографии на основе отечественного опыта, накопленного различными отраслями промышленности, представлены результаты исследований по управлению рисками реализации инвестиционных строительных проектов в области безопасности и охраны труда и повышению эффективности систем управления безопасностью и охраной труда с учетом и на основе управления влиянием человеческого фактора. Авторами проведена работа по обобщению опыта по управлению реализацией крупных инвестиционных строительных проектов АО «НИПИГАЗ», предложены рекомендации по повышению эффективности системы управления рисками в области безопасности и охраны труда на каждом этапе реализации инвестиционного строительного проекта, а также представлены результаты практической реализации предложений. Настоящая монография может быть интересна руководителям и сотрудникам отраслевых компаний, научным работникам, аспирантам и студентам, а также всем, кто интересуется проблемами повышения эффективности системы управления рисками, управления знаниями и опытом, повышения эффективности систем управления безопасностью и охраной труда.
SKRINING FAKTOR RISIKO PENYAKIT HIPERTENSI
Authors: Novendy Novendy , Christy Sannya , Devina Vania , Alexander Devin
Published: August 2022

According to Tangerang District Health Office (2018) data, hypertension is the second most common disease in health centers. Puskesmas Legok, which is located in Tangerang Regency, also saw a 21% increase in hypertension cases from 2020 to 2021. Hypertension is a disease that can be avoided if the risk factors are identified early on. As a result, in order to prevent the onset of this disease, it is necessary to conduct a screening activity for hypertension risk factors. This health service activity employs risk factor screening via a questionnaire that includes questions about modifiable and non-modifiable risk factors. This activity drew a total of 30 participants who did not have hypertension. The screening results revealed that the risk factors with the highest proportion value were age (90%), overweight (60%), non-routine consumption of fruit (50%), and non-routine consumption of vegetables (80%). The outcomes of risk factor screening activities were able to filter out some of the risks that exist in a person that can cause hypertension. As a result, those who have these risk factors require extra care. Additional activities are required to educate the public about the importance of screening risk factors for hypertension as early as possible in order to prevent hypertension from developing in the future.ABSTRAK:Berdasarkan data dari Dinas Kesehatan Kabupaten Tangerang (2018), hipertensi menduduki peringkat kedua dari sepuluh penyakit terbanyak di puskesmas. Puskesmas Legok yang merupakan salah satu wilayah di Kabupaten Tangerang juga mengalami peningkatan kasus penyakit hipertensi dari tahun 2020 ke 2021 sebesar 21%. Penyakit hipertensi merupakan penyakit yang dapat dicegah dengan mengetahui secara dini faktor risiko yang ada. Sehingga perlu dilakukan suatu kegiatan skrining faktor risiko penyakit hipertensi sebagai suatu upaya pencegahan timbulnya penyakit ini. Metode yang digunakan dalam kegiatan bakti kesehatan ini adalah melakukan skrining faktor risiko dengan menggunakan kuesioner yang terdiri pertanyan mengenai faktor risiko yang dapat maupun yang tidak dapat dimodifikasi. Sebanyak 30 peserta tidak memiliki penyakit hipertensi mengikuti kegiatan ini. Hasil skrining didapatkan faktor risiko yang nilai proporsinya  tinggi adalah usia (90%), berat badan lebih (60%), tidak rutin konsumsi buah (50%) dan tidak rutin konsumsi sayur (80%). Hasil kegiatan skrining faktor risiko yang telah didapatkan telah dapat menyaring beberapa risiko yang ada pada seseorang yang dapat menimbulkan terjadinya penyakit hipertensi. Maka dengan itu perlu perhatian khusus pada mereka yang memiliki faktor risiko tersebut. Kegiatan selanjutnya berupa edukasi kepada masyarakat mengenai pentingnya skrining faktor risiko penyakit hipertensi sedini mungkin perlu dilakukan, sehingga jangan sampai timbul penyakit hipertensi di kemudian hari
Pengaruh Motivasi, Lingkungan Kerja, Kompensasi terhadap Kepuasan Kerja PT Mitra Andalan Valasindo
Authors: Tirtowaluyo Evelyn , Turangan Joyce Angelique
Published: August 2022

Tujuan dari penelitian ini adalah untuk untuk mengetahui apakah motivasi, lingkungan kerja, dan kompensasi dapat mempengaruhi kepuasan kerja karyawan PT. Mitra Andalan Valasindo. Metode convenience sampling digunakan dengan menyebarkan kuesioner secara online yang kemudian diolah menggunakan smartPLS-SEM. Sampel dari penelitian ini adalah 50 karyawan atau seluruh karyawan yang bekerja di PT. Mitra Andalan Valasindo. Hasil dari penelitian ini adalah motivasi dan lingkungan kerja merupakan pengaruh yang positif dan signifikan terhadap kepuasan kerja, tetapi kompensasi merupakan pengaruh yang positif dan tidak signifikan terhadap kepuasan kerja karyawan PT. Mitra Andalan Valasindo.

 

The purpose of this study is to determine motivation, work environment, and compensation can affect employee job satisfaction at PT. Mitra Andalan Valasindo. Convenience sampling method was used by distributing online questionnaires which were then processed using smartPLS-SEM. The sample of this research is 50 employees or all employees who work at PT. Mitra Andalan Valasindo. The results of this study are motivation and work environment are positive and significant effect of job satisfaction, but compensation is a positive and insignificant effect of employee’s job satisfaction at PT. Mitra Andalan Valasindo.
POPULATION HEALTH STATUS AS ONE OF THE INDICATORS OF MODERN SOCIETY DEVELOPMENT
Authors:   Department of Public Health and Healthcare, Medical Institute, Derzhavin Tambov State University, Tambov, Russian Federation, CHERNYSHYOV A.V. , IRZHAEV D.I. ,   Department of Public Health and Healthcare, Medical Institute, Derzhavin Tambov State University, Tambov, Russian Federation, ZOLOTUKHINA A.YU. ,   Department of Medical Biology, Medical Institute, Derzhavin Tambov State University, Tambov, Russian Federation
Published: August 2022

The article discusses the health status of different age groups: children, adolescents and adults. Issues related to the development of pathological processes in terms of some occupational diseases are discussed. The influence of various factors on the state of health of the population, in particular, physical activity, conditions and nature of nutrition, is revealed. Attention is focused on the role of the health care system in maintaining the health of the population at the proper level. It is noted that the fundamental condition for the proper organization of a healthy lifestyle and maintaining a high level of health is the creation of a coordinated system of various state and public organizations that optimally interact with each other. Keywords: health status, health risk factors, population health.
AGENESIS OF THE DIAPHRAGM: A CASE REPORT AND A BRIEF LITERATURE REVIEW
Authors:   Republican Scientific Center for Cardiovascular Surgery, Dushanbe, Republic of Tajikistan, TURAKULOV F.A. , BARATOV A.K. ,   Republican Scientific Center for Cardiovascular Surgery, Dushanbe, Republic of Tajikistan
Published: August 2022

Objective: Agenesis of the diaphragm (AD) in adults is an extremely rare congenital malformation. To date, only a few descriptions of this pathology have been published in the scientific literature. The article presents a case of detection of a left-sided AD in a 25-year-old patient operated on for diaphragmatic relaxation. Additional examination methods, including echocardiography and ultrasonography of the abdominal organs and retroperitoneal space, did not reveal any other malformations in this patient. Due to the lack of plastic material of the appropriate size and type, plastic replacement of the diaphragm was postponed to the second stage of surgery. Keywords: Congenital malformations, anomalies of the diaphragm, aplasia of the diaphragm, agenesis of the diaphragm, agenesis of the diaphragm in adults, diaphragmatic hernia, plastic surgery of the diaphragm.
ANALYSIS OF ANTIBACTERIAL AND FUNGICIDAL ACTIVITY OF ALLIUM OSHANINII AND ALLIUM SUWOROWII DEPENDING ON THE ALTITUDE OF PLANT GROWTH
Authors:   Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, MIRZOEVA F.D.
Published: August 2022

Objective: To study the biological properties of plants of the genus Allium and their correlation with antimicrobial and fungicidal activity depending on the altitude of plant growth. Methods: Seeds, leaves and bulbs of widespread wild and endemic species of the genus Allium growing in various regions of the Republic of Tajikistan were the objects of the study. The antimicrobial activity of the obtained extracts was studied against standard museum microorganisms (test strains): Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930), Klebsiella pneumoniae (ATCC 4927), Escherichia coli (ATCC 4928). Antifungal activity was studied against Candida species. Results: Correlation of varying strength was discovered between the content of biocomponents with antimicrobial and fungicidal activity, the altitude of plant growth and place of its collection. The content of total polyphenols and the antioxidant activity of extracts obtained from various parts of the plants varied over a wide range. In some cases, there were direct correlations of varying strength between the content of polyphenols, antioxidative, antimicrobial and fungicidal properties of the plants. Conclusion: This study showed the insignificant correlations between the content of biocomponents and antimicrobial, and fungicidal properties of the studied types of onions, which did not depend on the growing zone. Keywords: Onion, plant, growth inhibition, extract, reference bacterial strains.
A SUCCESSION PLANNING MODEL FOR ACADEMIC HEADS
Authors: Gilbert S. Arrieta  , Caridad N. Barrameda  , I Ketut Sudarsana
Published: August 2022

This study identified the practices, issues and concerns, and key elements of a succession planning model for academic heads for the five private sectarian schools in the Philippines. It was conducted in school year 2018-2019, and participated by fifty-eight (58) religious administrators and lay academic heads and teachers Using the key features of participatory method, workshops, focus group discussion, and interviews were conducted for data gathering. The results showed that the practices in the selection and appointment of academic heads were administration’s preference, and criteria for selection and appointment of academic heads. From these practices, the issues and concerns that emerged were objectivity of decision, professional growth, spirituality and culture, and motivation. The elements of succession planning which are vision-mission, spirituality and culture, institutional policies, processes, and procedures, and professional growth were identified based on the practices, and issues and concerns. From these data, the succession planning model for academic heads was developed. The steps in the succession planning are understand the school organizational culture, build a shared vision, set and implement policies and leadership standards, provide personal and moral development programs, provide leadership development programs, and select and appoint academic heads. All policies and programs of the succession planning model must be anchored on the vision-mission of the schools. The faith and spiritual development programs (for private sectarian schools) or the personal and moral development programs (non-sectarian and public schools) are important in the preparation and appointment of future academic heads.
Moderasi Beragama
Authors: Apriani Ni Wayan , Aryani Ni Komang
Published: August 2022

This study aims to determine the moderating value contained in Geguritan Dharma Sunyata. The data in this study were collected using document study techniques. Furthermore, it is analyzed with the stages of data reduction, data presentation and drawing conclusions. From the results of data analysis, it was found that the value of religious moderation contained in Geguritan Dharma Sunyata was based on the teachings of Tat Twam Asi and Tri Kaya Parisudha. Tat Twam Asi's teachings are the basis of Hindu ethics in an effort to achieve moral improvement. Tat Twam Asi is a teaching that states the similarities between individuals so that it gives birth to the concept of compassion for all creatures in the world. Religious people should respect and appreciate each other even though they adhere to different religions.
PEMBENTUKAN KARAKTER DISIPLIN ANAK: SEBUAH TINJAUAN DARI PENDIDIKAN ANAK USIA DINI
Authors: Salsabila Fairuz , Lessy Zulkipli
Published: August 2022

Both environmental influences and education in the family and society have contributed significantly to form a child’s character, including his or her discipline character. This research is a qualitative approach that was conducted by soliciting ten parent respondents. Based on data collected through observation, interviews, and supporting documents, this research agrees with mainstream research findings of Islamic education research which is to mould the child’s discipline character in order to provide provisions for his or her future life, namely (1) the child grows and develops because of the parental upbringing. Therefore, his or her character reflects the values that exist in the family. (2) Societal environments and education have assumed a second role when the child socializes with his or her peers and with a wider social environment. As a result, greater influences will affect the development of the child. The formation of good character needs to be instilled in the child to live a life and grow positively. (3) Generally, the child grows up due to the influence of stimulus from the family and peers. If the stimulus is positive, the child will grow well and vice versa. The research suggests that parents, society, and especially Islamic education should invest greatly for the development of discipline character in the child due to his or her potential grows rapidly.
Literasi Digital Untuk Menanggulangi Perilaku Oversharing di Media Sosial
Authors: Dewi Bunga  , Cokorde Istri Dian Laksmi Dewi  , Kadek Ary Purnama Dewi
Published: August 2022

Media sosial memberikan fasilitas bagi warganet untuk bertukar informasi, mengunggah foto, video dan kegiatannya sehari-hari. Aktivitas berbagi informasi pribadi yang terlalu sering disebut dengan oversharing. Oversharing secara psikologi merupakan suatu kebutuhan manusia untuk diperhatikan dan mendapatkan dukungan sosial. Namun secara tidak langsung, aktivitas tersebut justru membahayakan pengunggahnya. Penelitian ini akan membahas dua permasalahan yakni 1) konteks privasi dan perlindungan data pribadi serta kerentanannya dan 2) literasi digital bagi masyarakat warganet untuk menanggulangi perilaku oversharing. Konsep privasi pada dasarnya memberikan pilihan bagi setiap orang untuk memilah ruang privat dan ruang publik atas dirinya. Data pribadi bertransformasi menjadi data publik ketika pemiliknya membagikan data pribadi tersebut ke ruang maya. Literasi digital sangat diperlukan untuk melindungi warganet dari ancaman bahaya di ruang maya seperti cyberbullying, intimidasi, bahkan kejahatan yang dilakukan secara langsung seperti perampokan akibat perilaku warganet yang pamer harta kekayaan di media sosial. Literasi digital akan meningkatkan kecerdasan sosial warganet untuk menentukan apa saja yang dapat dan layak diunggah di media sosial.

 

 

Kata kunci : literasi digital, oversharing, media sosial.
Studying opinion polarization on social media
Authors:   Department of Information Studies, University of California, Los Angeles, CA 90024, USA, Jiang Tianji
Published: August 2022

Opinion polarization on social media raises a lot of concerns today. In this study, the author provides a systematic review of publications about the issues since 2013 to show the achievements in the existing research on the topic, to sort out the relevant knowledge, and to provide some inspirations for future research in this area. This paper finds that opinion polarization on social media is initiated by three patterns of factors: increasing the homophily in discussions, increasing conflict in social media discussions, and facilitating the spread of misinformation. It also summarizes the existing findings on how to detect and measure opinion polarization in social media, and comes up with opportunities for further researches on this topic.
Nise da Silveira and the revolutionary use of art as Occupational Therapy in the psychiatric context
Authors: Lousa Teresa , Mikosz José Eliézer
Published: August 2022

Nise da Silveira, a Brazilian psychiatrist, carried out groundbreaking work in the treatment of the mentally ill. When she encountered the conventional treatments of the time, such as electroshock and lobotomy, was shocked by such violence. In rejecting such methods, she was ostracised by the clinical establishment. Thus, in 1946, she began to run an abandoned Occupational Therapy center, where, through artistic expression and affectionate contact, she would encourage the works produced by the patients as documents that opened up a new understanding of the psychiatric patient’s inner universe. Through Jung, Nise came to understand the importance of the symbols revealed in the images of Art Therapy.
Uma análise acerca das características do Mieloma Múltiplo: revisão de literatura
Authors: Torres Larissa Lima , Vieira Rafaella de Almeida , Vieira Gabriella de Almeida , Siqueira Emílio Conceição de
Published: August 2022

Objetivo: Analisar as características do Mieloma Múltiplo (MM). Revisão Bibliográfica: O MM é uma neoplasia do sistema hematopoiético, classificada como neoplasia de plasmócitos. O MM é caracterizado por uma proliferação anormal de linfócitos B clonais e terminalmente diferenciados. As células malignas estão presentes principalmente na medula óssea, mas também podem ser registradas no sangue periférico e em outros locais extramedulares. A apresentação clínica constitui dor óssea, anemia, hipercalcemia e insuficiência renal. O MM é precedido por uma fase precursora assintomática, a Gamopatia Monoclonal de Significância Indeterminada (MGUS), que se caracteriza pelo aumento do número de plasmócitos clonais na medula óssea sem lesão de órgão-alvo ou sinais clínicos associados à proliferação de plasmócitos. Considerações finais: O MM é a segunda maior causa de malignidade hematológica. Consiste em um câncer de células B maduras definida pela presença de ≥10% de plasmócitos clonais na medula óssea (ou plasmocitoma confirmado por biópsia de medula óssea). Alem disso, deve ser evidenciado por lesão de órgão-alvo tal qual hipercalcemia, insuficiência renal, anemia e lesões ósseas. É uma doença característica de pacientes acima de 60 anos, que afeta mais o sexo masculino e que é na maioria das vezes diagnosticada em fases mais avançadas. Esta ocasiona redução da qualidade de vida, principalmente pela dor óssea e pela fadiga.
Supralabyrinthine air cell is not present in superior semicircular canal dehiscence
Authors: Bhatt Alok A. , Lundy Larry B. , Rhyner Patricia A.
Published: August 2022

Objectives:

Superior semicircular canal dehiscence (SSCD) is defined as a defect in the bone overly the superior semicircular canal (SSC). The purpose of this study is to evaluate the pre-operative imaging examinations of patients who have undergone SSCD repair. We hypothesize that these patients will not have a supralabyrinthine air cell on the side of surgery.

Material and Methods:

Our group retrospectively reviewed 50 consecutive pre-operative computed tomography (CT) temporal bone examinations who had confirmed SSCD on intraoperative examination and underwent repair for the presence of a supralabyrinthine air cell.

Results:

100% of patients who had confirmed SSCD on intraoperative examination had no supralabyrinthine air cell on pre-operative CT of the temporal bone.

Conclusion:

This study shows that a supralabyrinthine air cell is not present in SSCD. When a supralabyrinthine air cell is present, the roof of the SSC is intact. CT and magnetic resonance imaging (MRI) are often performed together to evaluate for SSCD and exclude other etiologies. We propose that if a supralabyrinthine air cell is seen on MRI, no CT is necessary, thus avoiding unnecessary radiation exposure and additional imaging costs to the patient.
A novel device to micromanipulate oocytes during intracytoplasmic sperm injection
Authors: Bharadwaj Kishor K. S. , Rokade Sudesh V. , Yaswanth G. B. S. V. , Venkatraman Vaishalini , Kumar Praveen , Gupta Binal , Kusure Prashant Srimant , Abhishek Dharamkar Sai , Babu T. J. Ramnath , Bhargav Santosh D. B. , Joshi Charudutt
Published: August 2022

Objectives:

To demonstrate a novel, non-pneumatic, compliant mechanism-based micro gripper to immobilize oocytes for the Intracytoplasmic sperm injection (ICSI).

Material and Methods:

The micro gripper is designed intuitively based on different techniques available to design compliant mechanisms in the literature such as the Stiffness Maps technique, Kinetoelastostatic maps, and feasibility maps techniques. The gripper’s holder was made from a 2mm thick PMMA sheet; whereas, the gripper was fabricated using a hydrophilic sheet, a proprietary material of 3MTM. The gripper and holder were assembled using a biocompatible adhesive.

Results:

Experimental trials carried out with the gripper holder on the ICSI workbench showed that the developed gripper holder was able to hold the oocyte gently and firmly in place. A micro linear actuator was used to actuate the gripper-holder. The device was tested for its efficacy to perform ICSI by designing ICSI experiments with matured oocytes and sperm; it was found that the degeneration rate was absolutely zero percent for all the matured oocytes.

Conclusions:

A novel device to micro manipulate oocytes during intra-cytoplasmic sperm injection is presented in this paper and is based on the gripping principle as opposed to the conventional suction-based pipettes for holding the oocytes gently and firmly in place during ICSI. The degeneration rate was found to be zero using the gripper-based novel device.
Health-saving technologies in the educational space
Authors: Белоус О.В. , Василенко В.Г. , Тютюнникова Е.Б. , Арушанян Ж.А.
Published: August 2022

В статье авторы раскрывают особенности организации и основные направления поддержания здоровья в образовательном пространстве, а также рассматривают разные условия, в которых происходит сохранение психологического здоровья. Описывается необходимость в разработке концепции использования здоровьесберегающих технологий, создании специальных условий комфортного решения этого вопроса. Авторы анализируют разные подходы образовательного процесса для работы в условиях образовательных организаций. Далее предлагаются варианты реализации методической деятельности в сохранении психологического здоровья с помощью здоровьесберегающих технологий в условиях образования. Авторы рассматривают конкретные пути выстраивания здоровьесберегающего образовательного пространства.

In the article, the authors disclose the peculiarities of the organization and the main directions of maintaining health in the educational space, as well as consider different conditions in which psychological health is preserved. It describes the need to develop the concept of using health-saving technologies, to create special conditions for a comfortable solution of this issue. The authors analyze different approaches of the educational process for working in the conditions of educational organizations. Further, the authors propose options for implementing methodological activities in maintaining psychological health with the help of healthsaving technologies in educational conditions. The authors propose specific ways to build a healthy, safe educational space.
Features of the Soviet period of artistic academic education
Authors: Жунцзи В.
Published: August 2022

В статье рассмотрены особенности советского периода художественного академического образования. Проанализированы этапы ее становления. В начале ХХ вв. старая академическая система художественного образования подверглась значительным изменениям. Были разработаны новые программы обучения, отрицающие принципы академического образования. В дальнейшем были предприняты попытки возращения к старой академической системе с учетом социальных условий и партийной идеологии. Советский период оказал неоднозначное влияние на дальнейшее развитие академического образования, оставив большое количество явлений и направлений художественного творчества.

The article considers the features of the Soviet period of artistic academic education. The stages of its formation are analyzed. At the beginning of the twentieth century. the old academic system of art education has undergone significant changes. The ideology of the ruling party had a great influence on the formation of art education in the Soviet period. New curricula were developed that denied the principles of academic learning. Subsequently, attempts were made to return to the old academic system, taking into account social conditions and party ideology. The Soviet period had an ambiguous impact on the further development of academic education, leaving a large number of phenomena and trends in artistic creativity.
Information and cybersecurity technology in higher education institutions
Authors: Олейник А.С. , Герасимов В.М. , Халилуллин Ф.Н. , Гайнулова Ю.М. , Калинин Д.С.
Published: August 2022

Сегодня, в условиях широкой доступности интернета и стремительного развития средств связи, существует очень заметный разрыв в ожиданиях студентов и теми возможностями, которые могут предложить им учреждения высшего образования (вуз) России. При этих условиях формы и методы образовательной деятельности в отечественных вузов должны постоянно обновляться в зависимости от информационных потребностей и технологического развития общества. В то же время не последнее место в этом процессе должно занимать обеспечение информационной и кибербезопасности как образовательных материалов и другой информации ограниченного доступа, так и самой ИТинфраструктуры от случайных или направленных атак. Реализация указанных задач осложняется тем, что вузы России переживают сейчас период адаптации не только к объективным процессам информационного общества, но и к новым социально-политическим условиям с разноплановыми проявлениями конкурентной борьбы.

Today, with the widespread availability of the Internet and the rapid development of communications, there is a very noticeable gap in the expectations of students and the opportunities that higher education institutions (universities) in Russia can offer them. Under these conditions, the forms and methods of educational activities in domestic universities should be constantly updated depending on the information needs and technological development of society. At the same time, ensuring information and cybersecurity of both educational materials and other restricted access information, as well as the IT infrastructure itself from accidental or targeted attacks, should not be the last place in this process. The implementation of these tasks is complicated by the fact that Russian universities are currently undergoing a period of adaptation not only to the objective processes of the information society, but also to new socio-political conditions with diverse manifestations of competition.
Perbandingan Jenis Media Kaldness terhadap Effisiensi Limbah Rumah Makan dengan Metode MBBR
Authors: Subagyo Aldiansyah , Arifin Arifin , Kadaria Ulli
Published: August 2022

Limbah cair rumah makan mengandung bahan organik yang tinggi sehingga dapat menyebabkan meningkatnya kandungan pencemar di dalam badan air. Salah satu pengolahan yang dapat digunakan yaitu menggunakan metode Moving Bed Biofilm Reactor (MBBR). Penelitian ini dilakukan dengan variasi media kaldness K1, K3 dan K5 sebanyak 20% dari limbah yang diolah dan diberikan aerasi selama 8 jam. Tujuan dilakukan penelitian ini untuk mengetahui kualitas air limbah sebelum dan sesudah pengolahan, serta perbandingan effisiensi pengolahan terhadap parameter TSS dan Amoniak. Berdasarkan penelitian yang telah dilakukan, Kaldness K1 mampu menurunkan parameter TSS sebesar 95,53% dan Amoniak dari 0,14 mg/l menjadi 2,74 mg/l. Kaldness K3 mampu menurunkan parameter TSS sebesar 97,51% dan Amoniak dari 0,14 mg/l menjadi 1,4 mg/. Kaldness K5 mampu menurunkan parameter TSS sebesar 98,08% dan Amoniak dari 0,14 mg/l menjadi 2,27 mg/l.
Synthesis of mono-fluoromethyl 6,5-heteroaromatic bicycles using 1,3-difluoroacetone as a cyclising reagent
Authors: Liu Longbin , Cosgrove Brett , Clissold Cole , Malagu Karine , Chambers Mark , Dominguez Celia
Published: August 2022

The development of facile, wide scope synthetic methodologies providing access to fluorinated motifs is important in medic-inal chemistry; for our purposes, we are interested in developing fluorine-tagged compounds to investigate their utility in Huntington’s disease. Here, we describe a novel, operationally simple and mild procedure for the synthesis of mono-fluoromethyl 6,5-heteroaromatic bicycles using 1,3-difluoroacetone (DFA). The scope of the reaction was investigated, and 27 examples synthesized with yields up to 96%.
Enhanced structural control of soft-templated mesoporous inorganic thin films by inert processing conditions
Authors: Jara Fornerod Maximiliano , Alvarez-Fernandez Alberto , Williams Eric , Skoda Maximilian W. A. , Prieto-Simon Beatriz , Voelcker Nicolas H. , Stefik Morgan , Coppens Marc-Olivier , Guldin Stefan
Published: August 2022

Mesoporous thin films are widely used for applications in need of high surface area and good mass and charge transport properties. A well-established fabrication process involves the supramolecular assembly of organic molecules (e.g. block copolymers, and surfactants) with inorganic materials obtained by sol-gel chemistry. Typically, subsequent calcination in air serves to remove the organic template and reveal the pores. A major challenge for such coatings is the anisotropic shrinkage due to the volume contraction related to solvent evaporation, inorganic condensation, and template removal, affecting the final porosity as well as pore shape, size, arrangement and accessibility. Here, we show that a two-step calcination process, composed of high-temperature treatment in argon followed by air calcination, leads to reduced film contraction and enhanced structural control. Crucially, the formation of a transient carbonaceous scaffold enables the inorganic matrix to fully condense before template removal. The resulting mesoporous films retain a higher porosity as well as larger, more uniform pores with extended hexagonally closed-packed order. Such films present favorable characteristics for a variety of applications, such as improved mass transport of large biomolecules. This is demonstrated for the adsorption and desorption of lysozyme into the mesoporous thin films as an example of enzyme storage.
Targeted AURKA degradation: towards new therapeutic agents for neuroblastoma
Authors: Rishfi Muhammad , Krols Simon , Martens Fien , Sanders Ellen , Eggermont Aline , De Vloed Fanny , Goulding Joshua Robert , Risseeuw Martijn , Molenaar Jan , Speleman Frank , De wilde Bram , Van Calenbergh Serge , Durinck Kaat
Published: August 2022

Aurora kinase A (AURKA) is a well-established target in neuroblastoma (NB) due to its catalytic functions during mitosis and due to stabilisation of the key oncoprotein MYCN. We report a small structure-activity relationship (SAR) study of MK-5108-derived PROTACs against AURKA by exploring different linker lengths and both the 4- and 5-position as thalidomide exit vectors. PROTAC SK2188 induces the most potent AURKA degradation (DC50, 24h < 10 nM, Dmax, 1h 98%, Dmax, 24h, 80%) and significantly outperforms the parent inhibitor MK-5108 in a cell proliferation screen and patient-derived organoids. Treatment of NGP neuroblastoma cells with SK2188 induced concomitant MYCN degradation, high replication stress/DNA damage levels and apoptosis. Furthermore, altering the attachment point of the PEG linker to the 5-position of thalidomide allowed us to identify a potent AURKA degrader with a linker as short as 2 PEG units. With this, our SAR-study provides interesting lead structures for further optimization and validation of AURKA degradation as a potential therapeutic strategy in neuroblastoma.
Stereodivergent Approach to the Synthesis of gem-Diborylcyclopropanes
Authors: Hanania Nicole , Nassir Molhm , Eghbarieh Nadim , Masarwa Ahmad
Published: August 2022

We report a novel designed stereodivergent strategy for the synthesis of gem-diborylcyclopropnes. The reaction provides a highly modular approach for the preparation of cyclopropane rings variants bearing gem-(Bpin,Bpin), gem-(Bpin,Bdan), and gem-(Bpin,BF3K) , with outstanding levels of stereocontrol. This was achieved by diastereoselective Pd-catalyzed cyclopropanation reactions of gem-diborylalkenes with α-diazoarylacetates and α-diazoaryl-trifluoromethyl. Key to the success of this general protocol was the diastereoselective trifluorination reaction of gem-diborylcyclopropanes followed by a stereospecific interconversion of the trifluoroborate-salts into the Bdan group.
Carbodiimide-fueled assembly of π-conjugated peptides regulated by electrostatic interactions
Authors: Yao Zefan , Kuang Yuyao , Kohl Phillip , Li Youli , Ardoña Herdeline Ann
Published: August 2022

Peptides naturally have stimuli-adaptive structural conformations that are advantageous for endowing synthetic materials with dynamic functionalities. Here, we investigate a carbodiimide-based approach, combined with electrostatic modulation, to instruct π-conjugated peptides to self-assemble and be responsive to thermal disassembly cues upon consumption of the assembly trigger. Quaterthiophene-functionalized peptides are utilized as a model system herein to study the formation of kinetically trapped structures at non-equilibrium states. Peptides were designed to have aspartic acid at the termini to allow intramolecular anhydride formation upon adding carbodiimide, which consequentially reduces the electrostatic repulsion and facilitates assembly. We show that the carbodiimide-fueled assembly and subsequent thermally assisted disassembly can be modulated by the net charge of the peptidic monomers, suggesting an assembly mechanism that can be encoded by sequence design. This carbodiimide-based approach for the assembly of designer π-conjugated systems offers a unique opportunity to develop bioelectronic supramolecular materials with controllable formation of transient structures.
Neither too little nor too much: finding the ideal proportion of excipients
Authors: Mitsutake Hery , Rodrigues da Silva Gustavo Henrique , Breitkreitz Márcia Cristina , de Paula Eneida , Nunes Bordallo Heloisa
Published: August 2022

Excipient’s homogeneity is of paramount importance during the development of pharmaceutical formulations due to its relation to stability, safety and efficacy. A direct and unique approach to evaluate such property is 3D Raman imaging. This technique characterizes the surface and inner part of preformulation samples, allowing to determine phase separation in the early stages of pharmaceutical development. Aiming to promote controlled release of the local anesthetic butamben (BTB), confocal 3D Raman microscopy was used to obtain its optimal proportion in Apifil®, Capryol® 90 and Transcutol®. Even if the microscopic images of some samples displayed very homogeneous surfaces, analysis of 3D maps showed that chemical distribution throughout the material was different. To investigate how concentration affects the homogeneity, mixture experimental design (DoE) was employed. From this analysis, it was revealed that correct amount of Capryol® 90 enhances both miscibility and solubility. Furthermore, suitable miscibility was observed in two ratio proportions of excipients: Solution 1: Apifil® 30.00%, Capryol 20.00% and Transcutol 10.00% (w/w), with a desirability of 0.783; and Solution 2: Apifil® 25.00%, Capryol 25.00% and Transcutol 10.00% (w/w), with 0.742 desirability. These results unequivocally demonstrated that confocal Raman microscopy combined to DoE can bring pharmaceutical development to a higher level.
rxnutils – A Cheminformatics Python Library for Manipulating Chemical Reaction Data
Authors: Kannas Christos , Thakkar Amol , Bjerrum Esben , Genheden Samuel
Published: August 2022

We introduce the Python package rxnutils that can be used to manipulate chemical reactions, reaction templates and reaction datasets. The package is built entirely on open-source software such as RDKit and is designed with robustness, extendibility, and reproducibility in mind. Currently, it consists of three sub-packages one for working with chemical entities, one provides pipelining capabilities, and one provides an end-to-end pipeline for preparing the US patent reaction dataset for modelling. In this software research note we discuss the design of the package and provide some code examples. The project is open-source with a Apache 2.0 license and available at GitHub: https://github.com/MolecularAI/reaction_utils
Binding stoichiometry and structural model of the HIV-1 Rev/importin β complex
Authors: Spittler Didier , Indorato Rose-Laure , Boeri Erba Elisabetta , Delaforge Elise , Signor Luca , Harris Simon J , Garcia-Saez Isabel , Palencia Andrés , Gabel Frank , Blackledge Martin , Noirclerc-Savoye Marjolaine , Petosa Carlo
Published: August 2022

HIV-1 Rev mediates the nuclear export of intron-containing viral RNA transcripts and is essential for viral replication. Rev is imported into the nucleus by the host protein importin β (Impβ), but how Rev associates with Impβ is poorly understood. Here, we report biochemical, mutational, and biophysical studies of the Impβ/Rev complex. We show that Impβ binds two Rev monomers through independent binding sites, in contrast to the 1:1 binding stoichiometry observed for most Impβ cargos. Peptide scanning data and charge-reversal mutations identify the N-terminal tip of Rev helix α2 within Rev’s arginine-rich motif (ARM) as a primary Impβ-binding epitope. Cross-linking mass spectrometry and compensatory mutagenesis data combined with molecular docking simulations suggest a structural model in which one Rev monomer binds to the C-terminal half of Impβ with Rev helix α2 roughly parallel to the HEAT-repeat superhelical axis, whereas the other monomer binds to the N-terminal half. These findings shed light on the molecular basis of Rev recognition by Impβ and highlight an atypical binding behavior that distinguishes Rev from canonical cellular Impβ cargos.
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells
Authors: Wiarda Jayne E , Trachsel Julian M , Sivasankaran Sathesh K , Tuggle Christopher K , Loving Crystal L
Published: August 2022

Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte function is challenging as the intestine contains a vastly heterogeneous mixture of cells. Pigs are an advantageous biomedical model, but deeper understanding of intestinal lymphocytes is warranted to improve model utility. Twenty-six cell types were identified in the porcine ileum by single-cell RNA sequencing and further compared with cells in human and murine ileum. Though general consensus of cell subsets across species was revealed, some porcine-specific lymphocyte subsets were identified. Differential tissue dissection and in situ analyses conferred spatial context, revealing similar locations of lymphocyte subsets in Peyer’s patches and epithelium in pig-to-human comparisons. Like humans, activated and effector lymphocytes were abundant in the ileum but not periphery of pigs, suggesting tissue-specific and/or activation-associated gene expression. Gene signatures for peripheral and ileal innate lymphoid cells newly discovered in pigs were defined and highlighted similarities to human innate lymphoid cells. Overall, we reveal novel lymphocyte subsets in pigs and highlight utility of pigs for intestinal research applications.
Application of Particular Solutions of the Burgers Equation to Describe the Evolution of Shock Waves of Density of Elementary Steps
Authors: Andrieieva Oksana , Tkachenko Victor , Kulyk Oleksandr , Podshyvalova Oksana , Gnatyuk Volodymyr , Aoki Toru
Published: August 2022

Particular solutions of the Burgers equations (BE) with zero boundary conditions are investigated in an analytical form. For values of the shape parameter greater than 1, but approximately equal to 1, the amplitude of the initial periodic perturbations depends nonmonotonically on the spatial coordinate, i.e. the initial perturbation can be considered as a shock wave. Particular BE solutions with zero boundary conditions describe a time decrease of the amplitude of initial nonmonotonic perturbations, which indicates the decay of the initial shock wave. At large values of the shape parameter , the amplitude of the initial periodic perturbations depends harmoniously on the spatial coordinate. It is shown that over time, the amplitude and the spatial derivative of the profile of such a perturbation decrease and tend to zero. Emphasis was put on the fact that particular BE solutions can be used to control numerical calculations related to the BE-based description of shock waves in the region of large spatial gradients, that is, under conditions of a manifold increase in spatial derivatives. These solutions are employed to describe the profile of a one-dimensional train of elementary steps with an orientation near <100>, formed during the growth of a NaCl single crystal from the vapor phase at the base of a macroscopic cleavage step. It is shown that the distribution of the step concentration with distance from the initial position of the macrostep adequately reflects the shock wave profile at the decay stage. The dimensionless parameters of the wave are determined, on the basis of which the estimates of the characteristic time of the shock wave decay are made.
Plasma Conversion of CO2 in DC Glow Discharge with Distributed Gas Injection and Pumping
Authors: Lisovskiy Valeriy , Dudin Stanislav , Platonov Pavlo , Yegorenkov Vladimir
Published: August 2022

Accumulation of carbon dioxide in the Earth's atmosphere leads to an increase in the greenhouse effect and, as a consequence, to significant climate change. Thus, the demand to develop effective technologies of carbon dioxide conversion grows year to year. Additional reason for research in this direction is the intention of Mars exploration, since 96% of the Martian atmosphere is just carbon dioxide, which can be a source of oxygen, rocket fuel, and raw materials for further chemical utilization. In the present paper, the plasma conversion of carbon dioxide have been studied in the dc glow discharge at the gas pressure of 5 Torr in a chamber with distributed gas injection and evacuation from the same side for the case of narrow interelectrode gap. The conversion coefficient and the energy efficiency of the conversion were determined using mass spectrometry of the exhaust gas mixture in dependence on CO2 flow rate and the discharge current and voltage. Maximum conversion rate was up to 78% while the energy efficiency of the conversion was always less than 2%. It was found that the discharge at this pressure can operate in normal and abnormal modes and the transition between the modes corresponds just to the maximum value of the conversion coefficient for a given gas flow. It was shown that even in anomalous regime, when the cathode is completely covered by the discharge, the discharge contraction occurs in whole range of parameters studied. The anode glow and the plasma column outside the cathode layer occupy the central part of the discharge only that reduces the conversion efficiency. Optical emission spectra from the carbon dioxide plasma were measured in the range of 200-1000 nm, which allowed to make a conclusion that the Oxygen atom emission is mostly origins from the exited atoms appearing after dissociation rather than after electron impact excitation.
THEORETICAL AND METHODOLOGICAL ASPECTS OF POPULATION POVERTY MEASUREMENT AS AN INDICATOR OF SOCIAL POLICY EFFICIENCY
Authors: Urchik Gаlina
Published: August 2022

Exacerbation of socio-economic challenges necessitates the assessment of the effectiveness of the social policy, and one of the indicators of which is the level of poverty. This highlights the feasibility of comparing existing methodological approaches to measuring poverty, substantiating their objectivity and the feasibility of using it to assess the effectiveness of the national social policy. The results of the study revealed the diversity of existing approaches to the definition of ‘poverty’, which combines economic, social, and political aspects; the existing approaches and criteria for determining poverty are summarized. The paper specifies the methodological features of assessing the scale of poverty within an objective approach to 1) monetary criteria (absolute and relative poverty line, other monetary limits in accordance with the methodology of the World Bank and the EU), 2) non-monetary poverty line (based on identifying multiple derivations deprivation). The author’s position is that the assessment of the extent of poverty should also be carried out within the framework of a subjective approach, which involves self-identification and self-assessment of their own standard of living (according to the survey).

The analytical study of trends and scales of poverty according to all methodological approaches and criteria for its definition is carried out. The novelty of this study is to identify trends and the overall level of effectiveness of national social policy in terms of all indicators of poverty. According to the results of comparative analysis of poverty indicators, the author's position on the objectivity of their reflection of the level of effectiveness of national policy is substantiated, the advantages, disadvantages, expediency and reservations on the application of existing methodological approaches to determining poverty to assess the effectiveness of the social policy.