bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S4 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: July 2023

Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the liver of PDAC mice
Supplementary Figure S3 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: July 2023

Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth
Supplementary Table S2 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: July 2023

Table S2: EnrichR analysis of FLT3 gene signatures
Supplementary Table S10 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: July 2023

Table S10: EnrichR analysis of CEBPA_UP signature
Supplementary Table S1 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: July 2023

Table S1: Transcriptome analysis of FLT3-ITD cell lines after FLT3 inhbition
Supplementary Table S6 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos
Published: July 2023

List of major molecular profiling platforms included in the cohort
Supplementary Table S3 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos
Published: July 2023

Baseline Patient Characteristics – Cohort B
Supplementary Table S1 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos
Published: July 2023

Baseline Patient Characteristics – Overall Cohort
Figure S9 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: July 2023

Epigenetic remodeling of CAR T-cells by EGR2 knockout and effect of type I IFN signaling on the development of memory and exhaustion. A, Volcano plots showing differentially accessible chromatin regions within genes between KLF2+ and MKI67+ CD8+ T-cells. B, Volcano plots depicting differentially accessible chromatin regions within genes between EGR2 and AAVS1 knockout (KO) CD8+ CAR T-cells. C, Representative contour plots showing frequencies of TIM3- and LAG3-expressing CD8+ CAR-T cells after exposure to IFNβ (1ng/mL) following chronic CAR stimulation. D, Proportions of CD27+ (left) or CD62L+ (right) CD8+ CAR-T cells after exposure to IFNβ. E, Representative contour plots showing frequencies of CD45RO+CD27+ CD8+ CAR-T cells after IFNAR blockade (Anifrolumab, 1µg/mL) during chronic antigen stimulation. F, Frequencies of TIM3+LAG3+ CD8+ CAR-T cells after IFNAR blockade. G, Cytolytic capacity of CAR T-cells as measured by normalized cell index kinetics using the xCELLigence real-time cytotoxicity assay following chronic stimulation with target cancer cells in the setting of either IFNβ or IFNAR blockade. H, Normalized cell index at 75 hours after challenge with target cancer cells. All experiments were conducted using healthy donor T-cells from independent donors (Mann-Whitney test, n = 4). *P < 0.05, *P < 0.01, ***P < 0.001, ns.: not significant.
Figure S6 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Authors: Jung In-Young , Bartoszek Robert L. , Rech Andrew J. , Collins Sierra M. , Ooi Soon-Keat , Williams Erik F. , Hopkins Caitlin R. , Narayan Vivek , Haas Naomi B. , Frey Noelle V. , Hexner Elizabeth O. , Siegel Donald L. , Plesa Gabriela , Porter David L. , Cantu Adrian , Everett John K. , Guedan Sonia , Berger Shelley L. , Bushman Frederic D. , Herbst Friederike , Fraietta Joseph A.
Published: July 2023

Pathways regulated by EGR2 in CD8+ CAR T-cells. (A-C) Top pathways differentially expressed in EGR2 knockout CD8+ CAR-T cells compared to AAVS1 knockout CAR T-cells. Libraries used in this enrichment analysis: A, Reactome 2016. B, NCI-Nature Pathway Interaction Database 2015. C, ARCHS4 transcription factor (TF) co-expression.
Supplementary Figure S3 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos
Published: July 2023

Survival outcomes according to KEAP1 (A), SMARCA4 (B), and CDKN2A (C) co-mutation status in Cohorts A and B.
Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos
Published: July 2023

Integrated model for patient stratification and clinical outcome prediction with KRAS G12Ci monotherapy in KRASG12C-mutant NSCLC.
Supplementary Figures S1-S8 from An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression
Authors: Indeglia Alexandra , Leung Jessica C. , Miller Sven A. , Leu Julia I-Ju , Dougherty James F. , Clarke Nicole L. , Kirven Nicole A. , Shao Chunlei , Ke Lei , Lovell Scott , Barnoud Thibaut , Lu David Y. , Lin Cindy , Kannan Toshitha , Battaile Kevin P. , Yang Tyler Hong Loong , Batista Oliva Isabela , Claiborne Daniel T. , Vogel Peter , Liu Lijun , Liu Qin , Nefedova Yulia , Cassel Joel , Auslander Noam , Kossenkov Andrew V. , Karanicolas John , Murphy Maureen E.
Published: July 2023

Supplementary Figure S1. The Y107H variant of p53 is comparable to WT p53 for growth suppression and apoptosis.
Supplementary Figure S2. The Y107H variant is impaired for transactivation of a subset of p53 target genes, including PADI4, PLTP, and HHAT.
Supplementary Figure S3. The Y107H protein is impaired for binding to p53 response elements.
Supplementary Figure S4. Structural analysis of the Y107H variant shows similar structure but decreased thermal stability and increased propensity to misfold into mutant p53 conformation.
Supplementary Figure S5. Mice with the Y107H variant have increased cancer risk.
Supplementary Figure S6. Colorectal cancer cells harboring hypomorphic variants have increased sensitivity to the glutaminase inhibitor CB-839.
Supplementary Figure S7. PADI4 is a p53 target and has tumor suppressive activity.
Supplementary Figure S8. PADI4 correlates with increased immune signatures and wild-type p53 in human cancers.
Supplementary Table 5 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: July 2023

Cell type ontologies derived from snRNA-seq data.
Supplementary Table 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: July 2023

Quality control and filtering of snRNA-seq data.
Suppl. Table 5 from The DNA Damage Response and Inflammation in Cancer
Authors: Klapp Vanessa , Álvarez-Abril Beatriz , Leuzzi Giuseppe , Kroemer Guido , Ciccia Alberto , Galluzzi Lorenzo
Published: July 2023

PARP signaling and inflammation in cancer
Suppl. Table 3 from The DNA Damage Response and Inflammation in Cancer
Authors: Klapp Vanessa , Álvarez-Abril Beatriz , Leuzzi Giuseppe , Kroemer Guido , Ciccia Alberto , Galluzzi Lorenzo
Published: July 2023

NHEJ and inflammation in cancer
Suppl. Table 1 from The DNA Damage Response and Inflammation in Cancer
Authors: Klapp Vanessa , Álvarez-Abril Beatriz , Leuzzi Giuseppe , Kroemer Guido , Ciccia Alberto , Galluzzi Lorenzo
Published: July 2023

BER and inflammation in cancer
Figure 2 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: July 2023

A, Schematic describing IUE-based H3K27M-driven brain tumor modeling. Different combinations of piggyBac and CRISPR vectors are delivered into NSCs lining the LRL at E12.5. After birth, mice develop tumors representing distinct DMG subtypes. Inset: mutation combinations represented in H3K27M models and the acronyms used to refer to them. B, Immunofluorescence and IHC detection of GFP, K27M, Ki-67, and hematoxylin and eosin (H&E) in coronal hindbrain sections from tumor-bearing, symptomatic mice. Embryos were electroporated with vectors encoding (i) H3.3K27M, p53LOF, PDGFRAWT (KPP); (ii) H3.1K27M, ACVRAG328V, PIK3CAE545K (H3.1KACVPIK); (iii) H3.3K27M, PPM1DΔC, PIK3CAE545K (KPPMPIK); and (iv) H3.3K27M, NF1LOF, FGFR1N457K (KNF). Tumor cells are GFP+. Higher magnification panels below each low-magnification panel are of the tumor bulk in the brainstem, i.e., pons and medulla, which are directly below the cerebellum and fourth ventricle. Scale bars represent 1 mm in the immunofluorescence panels and 200 μm in the IHC panels. C, Immunofluorescence of tumor tissue sections in the pons or medulla to confirm the presence of cointroduced mutations and for colocalization with various markers. PIK3CA and PPM1D are coexpressed in HA+ KPPMPIK tumor cells (left); ACVR1 and OLIG2 colocalize in H3.1KACVPIK tumors (middle, top); FGFR1 is upregulated in HA+ KNF tumor cells (middle, bottom); and PDGFRA is expressed in K27M+ KPP tumor cells (right). Scale bars, 50 μm. D, Kaplan–Meier survival curves of IUE, tumor-bearing mice carrying different combinations of mutations. KPP (n = 6), H3.1KACVPIK (n = 13), KPPMPIK (n = 22), and KNF (n = 17). Statistical comparisons using the log-rank Mantel–Cox tests are described in Supplementary Table S2.
Data from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: July 2023

Abstract
Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by clonal mutations in histone genes. They often harbor a range of additional genetic alterations that correlate with different ages, anatomic locations, and tumor subtypes. We developed models representing 16 pHGG subtypes driven by different combinations of alterations targeted to specific brain regions. Tumors developed with varying latencies and cell lines derived from these models engrafted in syngeneic, immunocompetent mice with high penetrance. Targeted drug screening revealed unexpected selective vulnerabilities—H3.3G34R/PDGFRAC235Y to FGFR inhibition, H3.3K27M/PDGFRAWT to PDGFRA inhibition, and H3.3K27M/PDGFRAWT and H3.3K27M/PPM1DΔC/PIK3CAE545K to combined inhibition of MEK and PIK3CA. Moreover, H3.3K27M tumors with PIK3CA, NF1, and FGFR1 mutations were more invasive and harbored distinct additional phenotypes, such as exophytic spread, cranial nerve invasion, and spinal dissemination. Collectively, these models reveal that different partner alterations produce distinct effects on pHGG cellular composition, latency, invasiveness, and treatment sensitivity.
Significance:
Histone-mutant pediatric gliomas are a highly heterogeneous tumor entity. Different histone mutations correlate with different ages of onset, survival outcomes, brain regions, and partner alterations. We have developed models of histone-mutant gliomas that reflect this anatomic and genetic heterogeneity and provide evidence of subtype-specific biology and therapeutic targeting.
Supplementary Data Legends from HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer
Authors: Attalla Sherif Samer , Boucher Jonathan , Proud Hailey , Taifour Tarek , Zuo Dongmei , Sanguin-Gendreau Virginie , Ling Chen , Johnson Gabriella , Li Vincent , Luo Robin B. , Kuasne Hellen , Papavasiliou Vasilios , Walsh Logan A. , Barok Mark , Joensuu Heikki , Park Morag , Roux Philippe P. , Muller William J.
Published: July 2023

Legends for Supp. Figures S1-20
Suppl Figure S12 from Inhibition of microsomal prostaglandin E2 synthase reduces collagen deposition in melanoma tumors and may improve immunotherapy efficacy by reducing T cell exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S12 shows the Frequencies of tumor-infiltrating immune cells in tumors treated with celecoxib or CAY10678 as monotherapy or combined with and PD-1 blockade
Suppl Figure S11 from Inhibition of microsomal prostaglandin E2 synthase reduces collagen deposition in melanoma tumors and may improve immunotherapy efficacy by reducing T cell exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S11 shows the effect of CAY10678 on the production of arachidonic acid metabolites from murine BrafV600E melanoma cells
Supp Table S1 from Inhibition of microsomal prostaglandin E2 synthase reduces collagen deposition in melanoma tumors and may improve immunotherapy efficacy by reducing T cell exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Supplementary Table 1
Supp Figure S7 from Inhibition of microsomal prostaglandin E2 synthase reduces collagen deposition in melanoma tumors and may improve immunotherapy efficacy by reducing T cell exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S7 shows the correlation between PTGES mRNA level and collagen-related genes in a cohort of patients with advanced melanoma
Table S6 from Characterizing the immune microenvironment and neoantigen landscape of Hürthle cell carcinoma to identify potential immunologic vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald A. , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Neopeptides (11mer) associated with SNV alterations in HCC
Table S5 from Characterizing the immune microenvironment and neoantigen landscape of Hürthle cell carcinoma to identify potential immunologic vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald A. , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Neopeptides (10mer) associated with SNV alterations in HCC
Supp Figure S3 from Inhibition of microsomal prostaglandin E2 synthase reduces collagen deposition in melanoma tumors and may improve immunotherapy efficacy by reducing T cell exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S3 shows mfIHC staining details
Table S4 from Characterizing the immune microenvironment and neoantigen landscape of Hürthle cell carcinoma to identify potential immunologic vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald A. , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Neopeptides (9mer) associated with SNV alterations in HCC
Table S2 from Characterizing the immune microenvironment and neoantigen landscape of Hürthle cell carcinoma to identify potential immunologic vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald A. , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Somatic mutations, insertions, deletions identified in 40 HCC tumors
Figure S3 from Characterizing the immune microenvironment and neoantigen landscape of Hürthle cell carcinoma to identify potential immunologic vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald A. , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Scatter plot matrix showing the negative correlation between SNV mutations, neoantigen load, and immune infiltration scores.
Figure S1 from Identification of an imidazopyridine-based compound as an oral selective estrogen receptor degrader for breast cancer therapy
Authors: Pan Mengwu , Solozobova Valeria , Kuznik Nane C. , Jung Nicole , Graessle Simone , Gourain Victor , Heneka Yvonne M. , Cramer von Clausbruch Christina Alexandra , Fuhr Olaf , Munuganti Ravi S.N. , Maddalo Danilo , Blattner Christine , Neeb Antje , Sharp Adam , Cato Laura , Weiss Carsten , Jeselsohn Rinath M. , Orian-Rousseau Veronique , Bräse Stefan , Cato Andrew C.B.
Published: July 2023

Volcano plots and Hallmark gene set analyses showing pathways targeted by X15695.
Data from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Hürthle cell carcinoma (HCC) is a rare type of thyroid cancer with high rates of distant metastasis and recurrence. Along with the scarcity of effective systemic therapies for HCC, these factors contribute to poor clinical outcomes. The immunologic features of HCC are poorly defined and response rates with immune checkpoint blockade have not been reported. A more comprehensive understanding of the immune landscape and factors that predict response to checkpoint inhibitors is needed.

We performed RNA sequencing on 40 tumors to characterize the neoantigen landscape and immune microenvironment of HCC. We analyzed transcriptomic profiles, tumor-infiltrating immune cell populations, and measures of T-cell activation/dysfunction and correlated these to genetic features such as tumor mutation burden, neoantigen burden, mitochondrial mutations, and LOH from chromosomal uniparental disomy. Finally, immune profiles of patients with recurrence were compared with those of patients without recurrence.

HCC tumors exhibited low levels of immune infiltration, with the more aggressive widely invasive phenotype associated with more immune depletion. There was a negative correlation between tumor mutation burden, neoantigen burden, programmed cell death ligand 1 (PD-L1) expression, and the immune infiltration score. HCC tumors that exhibited a global LOH from chromosomal uniparental disomy or haploidization had the lowest level of immune infiltration. HCC tumors that recurred displayed an immune-depleted microenvironment associated with global LOH and aerobic glycolysis.

These findings offer new insights into the functional immune landscapes and immune microenvironment of HCC. Our data identify potential immunologic vulnerabilities for these understudied and often fatal cancers.
Significance:
The immune landscape of HCC is poorly defined and response rates to immunotherapy have not been reported. The authors found the immune microenvironment in HCC to be depleted. This immunosuppression is associated with a global LOH from haploidization and uniparental disomy, resulting in whole chromosome losses across the genome.
De Fragmentos Completos a Avenida Paulista
Authors: Santos Guilherme Caldas dos Santos , Queluz Marilda Lopes Pinheiro
Published: July 2023

Parte de uma pesquisa mais abrangente sobre Fragmentos Completos, uma extensa história em quadrinhos sobre a Avenida Paulista produzida por Luiz Gê, e pela equipe por ele coordenada, por ocasião do centenário desse logradouro da cidade de São Paulo, em 1991. Tem como objetivo abordar as duas diferentes instâncias em que história em quadrinhos foi publicada, bem como contextualizar o veículo em que foi originalmente publicada, a Revista Goodyear. Busca compreender como essa história em quadrinhos resultou dos meios tecnológicos das épocas em que foi criada e relançada, os ajustes de discurso e outras diferenças relevantes entre dois momentos de uma obra que foi o ponto culminante nos esforços do autor em construir para a cidade de São Paulo uma imagem de depositária de um ideal de brasilidade urbana e moderna.
Desenvolvimento de coleções de materiais informacionais: análise da produção científica e vertentes temáticas (2011-2020)
Authors: Machado Raymundo N.
Published: July 2023

O desenvolvimento de coleções, como campo de pesquisa, vem sendo estudado em diversos ângulos e, na contemporaneidade — norteada pelo avanço acentuado das tecnologias da informação e sua aplicação no contexto das bibliotecas —, passa por mudanças, de modo que novas percepções se tornam objeto de estudo que contribui em ações no campo das coleções de materiais informacionais.  O objetivo foi estudar as publicações e as vertentes temáticas no tema desenvolvimento de coleções, indexada Brapci, no período de 2011 a 2020. Este estudo se caracteriza como sendo de natureza descritiva, com abordagem quantitativa e qualitativa, tendo como material de análise o artigo científico. A produção científica analisada é de natureza assimétrica e unimodal, totalizando 61 artigos, escritos por 112 autores distintos, e publicados em 21 periódicos da área de Biblioteconomia e Ciência da Informação. Os anos de 2015 e 2017 foram o ápice da produção. As vertentes temáticas levantadas foram quatro: 1) biblioteca e desenvolvimento de coleções; 2) livro digital; 3) coleção jurídica e 4) seleção de materiais informacionais. Como conclusão a pesquisa sinaliza para novos contextos de estudo, como, por exemplo, os aspectos relacionados à aquisição do livro digital e à formação de coleção jurídica, como também a formação e o desenvolvimento de coleios no contexto híbrido.
Instrumentos de avaliação do ajuste psicossocial à amputação, uso e satisfação com a prótese: uma revisão sistemática da literatura
Authors: Pires Greicy Kelly Wosniak , Luza Lisiane Piazza , Rudolpho Sara Maria Soffiatti , Rodrigues Paula Lopes , Silva Rudney da
Published: July 2023

O ajuste à amputação envolve tanto questões físicas quanto psicossociais e a satisfação com o membro artificial. Objetivo: Revisar sistematicamente a literatura acerca dos instrumentos que avaliam o ajuste psicossocial à amputação e uso da prótese e a satisfação com a prótese em pessoas com amputação de membro inferior. Métodos: Fonte de dados: Medline via Pubmed, Web of Science e Scopus. Critérios de elegibilidade: estudos originais que utilizaram questionários para avaliar o ajustamento psicossocial a amputação e uso da prótese e a satisfação com a prótese. Participantes: pessoas com amputação de membro inferior. Métodos de avaliação e síntese dos estudos: todas as análises foram realizadas por três avaliadores, de forma independente, sendo os resultados apresentados de forma descritiva, em tabelas. Resultados: Foram encontrados 239 artigos na busca inicial, sendo incluídos 12 artigos ao final da revisão. Nestes, foram identificados 14 questionários que avaliam o ajuste psicossocial e a satisfação com a prótese, porém, somente 5 são validados especificamente para a população amputada. Conclusão: A Trinity Amputation and Prosthesis Experience Scale (TAPES) e o Prosthesis Evaluation Questionnaire (PEQ) são os instrumentos mais utilizados, sendo sempre importante uma seleção criteriosa dos instrumentos a serem utilizados nas pesquisas e intervenções a fim de se obter dados válidos, confiáveis e comparáveis. Número de registro da revisão sistemática: CRD42019097279.
Utilização do diário de quedas como ferramenta de monitoramento das quedas em pessoas com doença de Parkinson: uma revisão sistemática
Authors: Silva Jefferson Carlos Araujo , Olegário Raphael Lopes , Santos Yuri Matias Alves dos , Oliveira Sabrynna Brito , Queiroz Liana Mayara Caland , Pinheiro Hudson Azevedo , Bezerra Lídia Mara Aguiar
Published: July 2023

As quedas em pessoas com Doença de Parkinson (DP) são fatores limitantes e incapacitantes, sua compreensão é complexa dada a natureza multifatorial. Neste contexto uma ferramenta, o diário de quedas, pode ser alternativa significante na compreensão deste evento. Objetivo: Avaliar a utilização do diário de quedas como ferramenta de monitoramento das quedas em pessoas com DP. Métodos: Trata-se de uma revisão sistemática de literatura que teve a seguinte questão norteadora: o diário de quedas é uma ferramenta adequada para monitorar as quedas em pessoas com DP? A busca nas bases de dados Pubmed, Medline, PEDro, Web of Science, Scopus e Cochrane Library foi realizada entre os meses de janeiro a março de 2022. A revisão foi registrada na plataforma PROSPERO sob o número de registro: CRD42018099127. Resultados: 192 estudos foram recuperados nas bases de dados, após adoção dos critérios de inclusão e exclusão, 6 estudos foram incluídos nesta revisão, a variável diário de quedas foi descrita sumariamente nos estudos analisados e extraído informações do que deveria conter em um diário de quedas. Conclusão: A análise permitiu concluir que os diários de quedas são ferramentas importantes para registro e compreensão do evento queda em pessoas com DP, no entanto, carecem de padronização.
Efeitos de um treinamento com dispositivo comercial de realidade virtual imersiva sobre a marcha e cognição de pessoas com doença de Parkinson
Authors: Rocha Poliany Silva , Silva Ane Kelly dos Santos da , Piemonte Maria Elisa Pimentel , Mendes Felipe Augusto dos Santos
Published: July 2023

Objetivo: Avaliar a eficácia e a usabilidade de um treinamento imersivo de realidade virtual usando o Samsung Gear VR OculusTM (SGVR) para marcha e cognitivo em pessoas com doença de Parkinson (DP). Foi realizado um ensaio clínico controlado, quase experimental e cego. Método: Quarenta pessoas com DP foram divididas em dois grupos. O Samsung Gear Virtual Reality Group (VRG) participou de 10 sessões, duas vezes por semana, com duração de uma hora cada, realizando quatro jogos que exigiam movimento da cabeça e deslocamento do centro de gravidade. O grupo controle não recebeu tratamento. Os participantes foram avaliados antes, após a intervenção e 30 dias após a intervenção, com avaliação da marcha por meio do teste Timed Up and Go, teste de caminhada de 10 metros, teste de caminhada de 30 segundos com tarefa simples e dupla e avaliação cognitiva com teste de fluência verbal, dígito para frente e para trás Testes de amplitude e teste Stroop Color. Ao final do treinamento, a VRG respondeu ao questionário System Usabilidade Scale para avaliar a usabilidade do sistema. Resultados: Embora o sistema tenha sido avaliado com excelente usabilidade pelos usuários, não houve efeitos de interação e, portanto, nossos resultados não suportam que o treinamento de realidade virtual imersiva usando jogos SGVR foi superior a nenhum treinamento. Conclusão: No entanto, quando cada grupo foi examinado separadamente, o VRG apresentou melhoras, após a intervenção e 30 dias após a intervenção, para velocidade da marcha (p<0,005 e p<0,001, respectivamente), memória de trabalho, atenção e processamento de informações (p<0,01 em ambos os momentos de avaliação), inibição de resposta, memória de trabalho e de longo prazo (p< 0,01 em 30 dias após a intervenção). A avaliação adicional do dispositivo SGVR é necessária.
Apontamentos sobre montagem e teoria crítica em Walter Benjamin
Authors: Souza Lucas Melo
Published: July 2023

Este artigo pretende esboçar alguns apontamentos sobre o conceito de montagem nos escritos de Walter Benjamin e a relação desse conceito com a teoria crítica benjaminiana. Em fragmentos metodológicos ligados ao projeto de um livro sobre Charles Baudelaire, que só vieram a público no fim dos anos 1960, encontra-se um dos raros registros da expressão “teoria crítica” (kritische Theorie). Ela é utilizada por Benjamin para caracterizar sua autocompreensão teórico-metodológica, numa vinculação direta dessa expressão a procedimentos de enquadramento e montagem associados à objetiva fotográfica ou fílmica. Sustentar o nexo explicitado nas notas metodológicas entre teoria crítica – na acepção benjaminiana dessa prática teórica – e montagem impõe algumas questões. Primeiro, é preciso saber o que vem a ser, para Benjamin, a montagem. Sobretudo nos anos 1930, o desenvolvimento dessa noção é prismado em diversos objetos, em ensaios sobre o cinema, o teatro épico de Brecht, as vanguardas dadá e surrealista, a literatura de Alfred Döblin e a historiografia materialista. Além disso, é preciso indicar em que sentido o procedimento oriundo das artes e dos novos aparelhos de reprodução técnica pode contribuir para a teoria. Benjamin não considera a montagem apenas do ponto de vista procedimental, mas enfatiza, por exemplo, a função pedagógica e o ganho cognitivo propiciados através de experimentos teatrais. Igualmente, Benjamin chama atenção para a possibilidade de expansão da percepção, propiciado pela técnica cinematográfica por meio do desrecalque do inconsciente ótico.
Sonho, ruína e história: a onirocrítica da sociedade capitalista nos escritos tardios de Walter Benjamin
Authors: Veliq Fabiano , Magalhães Paula
Published: July 2023

Nesse artigo, estudamos os escritos tardios de Walter Benjamin, compreendidos entre 1935-1940. Nossa hipótese é que os conceitos de sonho, ruína e história se articulam de maneira intrincada no pensamento da maturidade do autor. A estrutura do texto conta com duas partes argumentativas. A primeira, à luz dos livros N das Passagens e do Exposé (1939), visa examinar detalhadamente como Benjamin opera com uma concepção renovada de sonho a partir de sua inserção nos objetos materiais eles mesmos. A segunda parte é focada em certas passagens das teses Sobre o conceito de história (1940). Nela pretendemos dar conta de uma concepção de história renovada que é combativa e investigar qual a tarefa do historiador materialista para Benjamin.
Management of Stroke in Patients With Chronic Liver Disease: A Practical Review
Authors: Parikh Neal S. , Basu Elora , Hwang Mu Ji , Rosenblatt Russel , VanWagner Lisa B. , Lim Hana I. , Murthy Santosh B. , Kamel Hooman
Published: July 2023

Chronic liver disease (CLD) is a highly prevalent condition. There is burgeoning recognition that there are many people with subclinical liver disease that may nonetheless be clinically significant. CLD has a variety of systemic aberrations relevant to stroke, including thrombocytopenia, coagulopathy, elevated liver enzymes, and altered drug metabolism. There is a growing body of literature on the intersection of CLD and stroke. Despite this, there have been few efforts to synthesize these data, and stroke guidelines provide scant guidance on this topic. To fill this gap, this multidisciplinary review provides a contemporary overview of CLD for the vascular neurologist while appraising data regarding the impact of CLD on stroke risk, mechanisms, and outcomes. Finally, the review addresses acute and chronic treatment considerations for patients with stroke—ischemic and hemorrhagic—and CLD.
Measuring Attribution in Natural Language Generation Models
Authors: Rashkin Hannah , Nikolaev Vitaly , Lamm Matthew , Aroyo Lora , Collins Michael , Das Dipanjan , Petrov Slav , Singh Tomar Gaurav , Turc Iulia , Reitter David
Published: July 2023

Large neural models have brought a new challenge to natural language generation (NLG): it has become imperative to ensure the safety and reliability of the output of models that generate freely. To this end, we present an evaluation framework, Attributable to Identified Sources (AIS), stipulating that NLG output pertaining to the external world is to be verified against an independent, provided source. We define AIS and a two-stage annotation pipeline for allowing annotators to evaluate model output according to annotation guidelines. We successfully validate this approach on generation datasets spanning three tasks (two conversational QA datasets, a summarization dataset, and a table-to-text dataset). We provide full annotation guidelines in the appendices and publicly release the annotated data at https://github.com/google-research-datasets/AIS.
Language Embeddings Sometimes Contain Typological
Generalizations
Authors: Östling Robert , Kurfalı Murathan
Published: July 2023

To what extent can neural network models learn generalizations about language structure, and how do we find out what they have learned? We explore these questions by training neural models for a range of natural language processing tasks on a massively multilingual dataset of Bible translations in 1,295 languages. The learned language representations are then compared to existing typological databases as well as to a novel set of quantitative syntactic and morphological features obtained through annotation projection. We conclude that some generalizations are surprisingly close to traditional features from linguistic typology, but that most of our models, as well as those of previous work, do not appear to have made linguistically meaningful generalizations. Careful attention to details in the evaluation turns out to be essential to avoid false positives. Furthermore, to encourage continued work in this field, we release several resources covering most or all of the languages in our data: (1) multiple sets of language representations, (2) multilingual word embeddings, (3) projected and predicted syntactic and morphological features, (4) software to provide linguistically sound evaluations of language representations.
The Hoard from Bækkedal in Northern Denmark and the Use of Two-Horse Teams in the Late Nordic Bronze Age
Authors: Sarauw Torben , Hadsund Per Thorling , Lukesova Hana
Published: July 2023

This article examines the use and significance of two-horse teams within the Nordic Late Bronze Age cultural sphere in southern Scandinavia and the southwestern Baltic region. Its point of departure is a remarkable hoard found in the late summer of 2014 at Bækkedal in northern Jutland, Denmark. The hoard, dated to period V of the Bronze Age, differs from many other hoards of this period by virtue of its abundant and almost complete content of bridles and other harness components for a two-horse team, including cheek pieces, phalerae and jingle plates. Furthermore, organic material was preserved in the form of parts of the bridle, with bronzes in situ, together with bits and reins. It therefore provides important new information about the group of hoards that contain horse tack, given that it is now possible, for the first time, to see how a bridle was constructed. Moreover, it contributes to our understanding of driving with two-horse teams and four-wheeled wagons, which, given the quantity of horse tack in hoards, must have been more commonplace than indicated by the other finds in the archaeological record. Lastly, the local context of the hoard is examined and reveals an area rich in other contemporaneous deposit finds and numerous settlement traces.
A new species of Conchocarpus and first record of Euxylophora (Galipeinae, Zanthoxyloideae, Rutaceae) from Colombia
Authors: LONDOÑO-ECHEVERRI YEISON , TRUJILLO-LÓPEZ ANA MARÍA , PÉREZ-ZABALA JORGE ANDRÉS
Published: July 2023

Conchocarpus cardenasii, a new species from the Pacific biogeographical region in Colombia and named honors to the Colombian botanist Dairon Cárdenas (1957–2022), is described and illustrated with notes about its geographical distribution, phenology, conservation status, taxonomic affinities, and the morphology of its stamens. The basally sterile anthers it is the most distinctive feature, which is hitherto only reported for C. guyanensis, which however, can be easily differentiable by its corymbiform thyrses. This feature helps to recognize C. cardenasii from other morphologically resembling species such as C. grandis and C. jirajaranus, in addition to differences in leaves and fruits. Furthermore, the first record of Euxylophora paraensis for the Colombian Amazon is here presented, based on a specimen collected in 1951 by R. E. Schultes and I. Cabrera on the Apaporis River basin.
Anatomical and macromorphological data support a new species of Phyllanthus (Phyllanthaceae) from Southeastern Brazil
Authors: TORRES ALÍCIA MARQUES , DA SILVA MARCOS JOSÉ
Published: July 2023

Phyllanthus megastylus, a new species endemic from Southeastern Brazil, is described here based on anatomical and macromorphological data. It is known so far from the state of Espírito Santo and is morphologically similar to P. itamarajuensis, but differs by its densely papillose branches, pink pistillate flowers, disk pistillate with undulate margin and punctiform stigmas. We provide illustrations, preliminary conservation status, phenological data and images taken in habitat. In addition, the new species it is compared anatomically with similar species and its systematic positioning is discussed.