bluuebunny/crossref_metadata_2025 huggingface dataset:
Enterprise Approach to Modelling of Risks in the Project Lifecycle of Naval Aviation Asset Ship Integration
Authors: Cook Matthew , Mo John P.T.
Published: October 2021

A strategic capability of contemporary naval ships is the ability to launch and recover embarked aircraft such as helicopters in a maritime environment. Such operations are enormously challenging due to deck motion, limited landing space, visibility, ship’s superstructure, etc. This places extreme pressure on the pilot, ship’s crew and the platforms alike, making such shipboard operations the most dangerous of all helicopter flight missions. Therefore, the design and integration of equipment, systems and aids to ensure such operations are done as safely as is practicably possible, presents ship builders, aircraft manufacturers, engineers and pilots with some extremely demanding and complex problems. Major naval ship design/build programmes that include an aviation capability, will inevitably need to engage resources across multiple disciplines that include, but not limited to; engineering, design, logistics, administration, procurement, legal, alliance partners and the customer to manage project risks from the outset. This research highlights the need for a holistic/Systems Engineering approach that recognises risks across the wider ship programme, that can only be managed/resolved by cross-discipline collaboration. This paper presents a novel methodology to elicit risks qualitatively and models the relative risk profile of an aviation project throughout the ship programme lifecycle. The use of an enterprise model based on the three ‘P’ element methodology (3PE): Product, Process, People within an environment has been developed. Furthermore, the research outlines a continuous management and visualisation approach that enables a process of dynamic analysis to both reduce and/or mitigate residual risks progressively throughout the project lifecycle to acceptable levels.
Liderlik ve Okul Etkililiği Düzeyleri Arasındaki İlişki: Bir Meta Analiz Çalışması
Authors: YUMUŞAK Hanifi , KORKMAZ Mehmet
Published: October 2021

Okulun gelişimi ve etkililiği konusunda okul yöneticisinin formal ve informal liderlik özellikleri büyük bir öneme sahiptir. Bu doğrultuda, ilgili çalışmada liderlik ve okul etkililiği düzeyleri arasındaki ilişkinin meta-analiz yöntemi ile ortaya konması amaçlanmıştır. Bu amaç doğrultusunda liderlik ve okul etkililiği düzeyleri arasındaki ilişkileri inceleyen çalışmaların etki büyüklükleri arasında alt grup (moderatör) değişkenlere göre anlamlı bir farklılık olup olmadığı incelenmiştir. 2010-2020 yılları arasında liderlik ve okul etkililiği düzeyleri arasındaki ilişkiyi inceleyen, örneklem sayısı ve korelasyon katsayısı verilerini içeren çalışmalar araştırmaya dâhil edilmiştir. Araştırma kapsamındaki çalışmalara, ulusal ve uluslararası veri tabanları kullanılarak ulaşılmıştır (Ulusal Tez Merkezi, Web of Science (WOS), Education Resources Information Center (ERIC), Scopus, EBSCOhost, vb.). Alan yazın taraması sonucunda araştırmanın seçim ölçütlerine uygun 22 çalışma meta-analize dâhil edilmiştir. Araştırmada etki büyüklüğü değerlerinin hesaplanmasında “Fisher Z” değeri kullanılmıştır. Araştırma kapsamındaki çalışmaların birleştirilmiş etki büyüklüğü rastgele etkiler modeline göre hesaplanmıştır. Analiz sonucunda, liderlik ve okul etkililiği düzeyleri arasındaki ilişkinin genel etki büyüklüğünün pozitif yönlü ve yüksek düzeyde olduğu ortaya konmuştur. Ayrıca liderlik ve okul etkililiği düzeyleri arasındaki ilişkileri inceleyen çalışmaların etki büyüklükleri arasında moderatör değişkenlere (çalışmanın yapıldığı bölge, okul kademesi ve liderlik türleri) göre anlamlı bir farklılaşmanın olduğu görülmüştür. Araştırma kapsamında okulların etkililik düzeyini artırmak için okul yöneticilerinin öğretim süreç ve amaçları konusunda gelişimlerinin desteklenmesi önerilmektedir.
Clinical case of catatonic stupor developed as a result of acute respiratory disease COVID-19
Authors: Komarovskyi М , Mykytenko R , Onofreichuk Kh , Hryshchenkova O , Podhorna A , Kosolapov O , Zolotarov P
Published: October 2021

The aim of this work is to demonstrate and analyze a clinical case of catatonic stupor as a consequence of the complex effect of the infectious process, namely systemic inflammation and direct neurotoxicity of the SARS-CoV-2 virus on the nervous system. A retrospective analysis of outpatient and inpatient medical records was performed. . Analysis of clinical case proves the possibility of catatonic syndrome due to acute respiratory disease COVID-19. 2. Given that catatonia is an urgent condition, it is necessary to be vigilant about its occurrence
Pengayaan Literasi tentang Bahaya Sampah Plastik dengan Metode Storytelling untuk Santri Pondok Pesantren Nurul Qur'an Bogor
Authors: Bakthawar Puri , Gintings Mohammad Fajar Mediyawan , Al-Baroroh Aisyah , Meylinda Linda , Yamin Yamin
Published: October 2021

Salah satu isu yang cukup hangat dalam kondisi masyarakat Indonesia bahkan dalam kondisi global pada umumnya ialah mengenai permasalahan sampah plastik. Jika tidak mendapat respons yang serius, maka dikhawatirkan permasalahan sampah plastik akan menjadi ancaman bagi dunia, baik pada masa kini maupun pada masa depan. Penelitian dan kegiatan PKM yang dilakukan kali ini ialah mengenai Literasi Bahaya Sampah Plastik melalui Storytelling pada Siswa-siswi Pondok Pesantren Nurul Qur’an. Tujuan dari kegiatan PKM ini ialah untuk mengedukasi kalangan siswa pondok pesantren mengenai bahaya sampah plastik agar tumbuh kesadaran akan bahaya yang bisa datang jika sampah plastik tidak dikelola dengan baik. Kegiatan PkM ini juga bertujuan untuk mengembangkan kemampuan public speaking para siswa pondok pesantren dengan mengajarkan keterampilan storytelling berbahasa Inggris di kalangan siswa. Data penelitian diambil dari kegiatan PKM yang diadakan di Pondok Pesantren Nurul Qur'an Ciseeng Bogor. Metode Penelitian yang digunakan ialah metode storytelling menurut Anne Pellowski dalam bukunya The World of Storytelling (1990). Hasil kegiatan PKM menunjukkan adanya peningkatan kesadaran siswa-siswi atas bahaya sampah plastik serta peningkatan kemampuan Bahasa Inggris melalui kegiatan storytelling.
Pengenalan Nilai Budaya dengan Menggunakan Cerita Rakyat untuk Meningkatkan Literasi Bahasa Inggris di Taman Bacaan Masyarakat (TBM), Ciputat
Authors: Sari Anita , Nainggolan Erni Susanti , Maharini May Triranto , Merilia Sarita , Wirharyati Wirharyati
Published: October 2021

Budaya rakyat di definisikan sebagai satu kesatuan yang terkandung dalam budaya nasional yang menjadi identitas seseorang. Cerita rakyat adalah salah satu warisan kebudayaan nasional yang menjadi kehormatan bangsa dengan budaya yang beraneka ragam yang harus diperkenalkan kepada siswa sejak sekolah dasar. Artikel ini mendeskripsikan cerita rakyat “Malin Kundang” sebagai cara untuk meningkatkan literasi anak-anak dalam berbahasa Inggris. Kegiatan Pengabdian Kepada Masyarakat dengan tema “Introducing Cultural Values By Using Traditional Folktale To Improve English Literacy At Taman Baca Masyarakat (TBM) Kolong, Ciputat – Tangerang Selatan” bertujuan untuk memaksimalkan kegiatan membaca yang lebih menarik dan menumbuh kembangkan  literasi dengan menggunakan buku cerita daerah. Anak – anak binaan di Taman Baca Masyarakat (TBM) yang juga merupakan peserta Pengabdian Kepada Masyarakat (PKM) ini dapat menumbuh kembangkan literasi mereka yang mengandung nilai – nilai budaya pada” buku cerita daerah. Metode yang digunakan pada PKM ini berupa pendekatan komunikatif melalui bermain peran (roleplaying) dengan menggunakan puppet dan bercerita (storytelling). Roleplaying yang dilakukan menggunakan boneka yang merepresentasikan para karakter dalam cerita Malin Kundang dan diceritakan dengan teknik storytelling. Kemudian hasil pengabdian masyarakat yang diperoleh adalah peningkatan kesadaran akan pentingnya membaca serta  memperkaya pengetahuan bagi anak – anak akan nilai – nilai budaya daerah yang dapat diaplikasikan dalam keseharian mereka.
Modeling Strategy untuk Meningkatkan Kemampuan Public Speaking Siswa Madrasah Aliyah
Authors: Suhayati Lisa , Haryati Haryati , Kusumawati Anita , Ruisah Ruisah
Published: October 2021

Kemampuan berbahasa Inggris siswa, khususnya dalam bidang public speaking berpidato dalam Bahasa Inggris (speech) masih rendah. Tujuan kegiatan pengabdian kepada masyarakat ini menghasilkan bahan ajar berupa buku dan video untuk mendukung proses pembelajaran berpidato dalam bahasa Inggris dan untuk mengetahui pengaruh positif dari kedua bahan ajar dalam meningkatkan kemampuan berbicara siswa khusunya berpidato. Penulis menggunakan bahan ajar berbentuk buku dan video pembelajaran pidato dalam Bahasa Inggris untuk mengetahui pengaruh positif bahan ajar tersebut terhadap meningkatnya kemampuan berpidato. Kegiatan melibatkan seluruh siswa di tingkat Madrasah Aliyah di Pondok Pesantren Nurul Quran, Bogor. Hasil kegiatan PkM, dapat disimpulkan bahwa modeling strategy melalui buku ajar dan video pembelajaran dapat meningkatkan kemampuan siswa dalam berbahasa inggris, khususnya kemahiran public speaking dalam berpidato Bahasa Inggris (speech), siswa dapat mengaplikasikan kemampuan berbicara dalam Bahasa Inggris dalam kehidupannya sehari-hari secara berterima dan efektif, dan siswa mendapatkan penguatan dalam membangun dan meningkatkan rasa percaya diri yang merupakan karakter penting untuk dimiliki. Karakter memiliki rasa percaya diri ini diharapkan dapat memberikan banyak dampak positif bagi para santri untuk menunjang prestasi akademik maupun non-akademik.
Pengaruh Pelatihan, Disiplin, Dan Lingkungan Kerja Terhadap Kinerja Karyawan PT World Innovative Telecommunication
Authors: Putra Maha , Mukharom Mukharom , Nugroho Arief Teguh
Published: October 2021

Tujuan penelitian untuk mengetahui seberapa besar faktor gaya kepemimpinan transformasional dan kompesasi mempengaruhi kinerja karyawan. Jenis penelitian yang digunakan adalah kuantitatif. Dengan populasi Karyawan pada PT. World Innovative Telecommunication dengan jumlah sampel 80 responden. Untuk pengumpulan data meliputi observasi, penyebaran kuesioner dan studi kepustakaan. Metode analisis yang digunakan yaitu uji validitas, uji reabilitas, uji asumsi klasik, analisis linear berganda dan uji hipotesa. Saat penelitian dilakukan, secara parsial variabel Gaya Kepemimpinan Transforamsional (X1) berpengaruh signifikan terhadap Kinerja Karyawan (Y) dimana menghasilkan variabel Gaya Kepempinpinan Transformasinal (X1) nilai t hitung lebih besar dari nilai t tabel (2.469 > 1,66515) dengan nilai signifikasi dibawah 0,05 yaitu 0,016 maka H1 diterimaSecara Parsial variabel Kompensasi (X2) berpengaruh signifikan terhadap Kinerja Karyawan (Y), nilai t hitung lebih besar dani nilai t tabel (1.807  > 1,66515) dengan tingkat signifikan dibawah 0,05 yaitu 0.036.Secara Simultan variabel Gaya Kepempinan Transformasional (X1) dan Kompensasi (X2) berpengaruh signifikan terhadap Kinerja Karyawan (Y), nilai t hitung lebih besar dari nilai F tabel (3,214> 2,471) dengan tingkat signifikan dibawah 0.05 yaitu 0.002.Maka H3 diterima.
PEDAGOGICAL CONDITIONS FOR THE FORMATION OF LEADERSHIP QUALITIES OF FUTURE HEADS OF PRESCHOOL EDUCATION INSTITUTIONS
Authors: Volynets Yuliya , Stadnik Nadiia , Panchenko Tetiana
Published: October 2021

The urgency of the studied problem is because in conditions of significant socio-economic changes, the system of human resource management technologies becomes significant, especially relevant is the use of the potential of leadership influence. In this regard, this article is aimed at revealing the problem of developing leadership qualities of heads of preschool education institutions. The article highlights current issues of leadership development of future heads of preschool education. The leading method of the research of this problem is the analysis of the researched problem in pedagogical theory and practice and experimental check of pedagogical conditions of formation of leadership qualities of future heads of preschool educational institutions that allows to reveal and characterize features of formation of leading qualities of future heads of preschool educational institutions. The article identifies the components, criteria, indicators and describes the levels of leadership development of future leaders of preschool education. The basic concepts of the problem are defined: leader, leadership, professional qualities of the leader, leadership qualities of future heads of preschool educational institutions, pedagogical conditions of formation of leadership qualities of future heads of preschool educational institutions. Relevant requirements to the personal and professional qualities of a leader are revealed. The structural components of leadership qualities of future heads of preschool education institutions are characterized, namely: motivational-value, integrative-activity, directional-activity, emotional-reflexive. The pedagogical conditions of the formation of leadership qualities of future heads of preschool education institutions are substantiated. The offered materials of the article represent practical value for heads of preschool education institutions, educators-methodologists, and future teachers of preschool education.
As práticas pedagógicas no ensino remoto e a formação docente na Covid-19
Authors: Brazil Paulo Henrique de Assis , Brazil Danielle Farias Vitorino , Barbosa Claudio Sales , Maciel Maria da Conceição Carvalho
Published: October 2021

Este ensaio teve como tema discutir as práticas pedagógicas no ensino remoto e a formação docente na COVID-19, demostrando uma estratégia para que o ensino e aprendizado não fosse prejudicado devido à pandemia. A problemática da pesquisa é dada pelo seguinte questionamento: qual a possível solução encontrada para vencer os desafios que surgiram, em meio a pandemia do COVID-19 no Brasil, nas práticas pedagógicas docentes para que os calendários acadêmicos não sofressem alterações? Para solucionar a problemática o estudo teve, através da abordagem qualitativa realizada por meio de pesquisa bibliográfica, como objetivo geral, apresentar a importância na utilização das TIC’s nas práticas pedagógicas docentes para o desenvolvimento do ensino e aprendizagem durante a Covid-19. O trabalho, também, discute a importância das Tecnologias de informação e Comunicação (TIC´s), no novo modelo de aulas remotas emergencial. Como resultados, constatou-se que a solução encontrada, para que as aulas continuassem sem interrupções e o calendário acadêmico não sofresse alterações prejudiciais, foi a introdução de um novo formato de ensino, no qual substituía as aulas presenciais pelo modelo de aulas remotas através das TIC’s. Portanto, a capacitação na formação docente do ensino nesse atual processo de aulas remotas é fundamental para o sucesso na educação no país, pois professores atualizados e inteirados com essas inovações tecnológicas são o elo e os mediadores do conhecimento entre discentes e as tecnologias.
Roaming among humans: noteworthy records of jaguar (Panthera onca) close to human settlements in the Paraguayan Humid Chaco
Authors: Laino R. , Musalem K. , Weiler A. , González-Maya José F.
Published: October 2021

Jaguars (Panthera onca Linnaeus, 1758) have been extirpated from nearly 55 % of their original range in America and from almost 24 % in Paraguay. Here we present evidence of the presence of jaguar close to the most populated areas of Paraguay, in a human–dominated landscape in the Humid Chaco forests, highlighting how without other pressures, jaguars can inhabit densely populated areas and potentially disperse between established populations.
The gastropod Vitta zebra (Bruguière, 1792) (Neritidae): a possible amphidromous species threatened by human impact in Brazilian rivers
Authors: Lima L. L. C. , Moura J. V. S. , Barroso C. X. , Passos F. D.
Published: October 2021

Amphidromous organisms grow, feed and reproduce in rivers but the newly hatched larvae migrate to the marine environment where they develop. The juveniles then migrate to fresh water. The present study aims to record the occurrence of the gastropod Vitta zebra in the São Francisco River, northeastern Brazil, and to warn of the risks the species faces due to the possible effects of human impact on its life cycle. Studies on the presence of the species in this river are required in order to develop conservation strategies.
ВЕЛИКА ЄВРОПА: У МИНУЛОМУ ЧИ У МАЙБУТНЬОМУ
Authors: Єрмоленко Ірина
Published: October 2021

У даній статті досліджуються концепції Великої Європи, а також події у сучасному світі, які засвідчують їх присутність у геополітичному дискурсі, розкрито зв’язок між сформульованими ідеями та вказаними ідеями. Пояснюється, чому той чи інший аспект є актуальним у сьогоднішніх реаліях. Вкахзується на сучасні міжнародні проекти та наводяться відповідні аргументи, що дозволяє розглядати їх як варіації «Великої Європи». Враховуючи складні трансформаційні процеси, які сьогодні відбуваються у світі, стає очевидною об’єктивна потреба у становленні єдиного простору Великої Європи. Розглянуто одну із проблем, яка виникає на шляху створення єдиної Європи – це розширення кола міжнародних суб’єктів, кожний з яких має власні інтереси і погляди, що стає джерелом протиріч і конфліктів, які на даному етапі розвитку суспільства узгодити , на жаль, не вдається.
hidrotórax fetal asociado a hidropesia ¿manejo expectante o intervencionista?
Authors: Ortiz Escobar Alexa Gianina , Meneses Ruiz Katherine
Published: October 2021

El hidrotórax fetal es la acumulación de líquido libre en la cavidad pleural fetal. Se asocia muy frecuentemente al hidrops fetalis entidad de elevada mortalidad perinatal, de etiología multifactorial y caracterizado por anasarca generalizada, con acumulaciónde líquido en algunas cavidades serosas del organismo fetal. Es importante establecer con antelación esta condición, ya que debe conocerse la causa más probable, para ayudar en la mejor reanimación al nacimiento. Se presenta el reporte de un caso en la ciudad de Cartagena. Colombia. Paciente de 35 años de edad, secundigestante de grupo sanguíneo RH positivo, con antecedente quirúrgico de resección de tumor dermoide en pared abdominal, músculos rectos abdominales, con colocación de malla de propileno. Embarazo anterior sin alteraciones. A las treinta y una semana de gestación se hace diagnóstico ecográfico de derrame pleural bilateral fetal. Se realiza intervención intrauterina para drenar líquido y colocación de dren pleuroamniotico. Por no presentar mejoría se decide nuevamente toracocentesis fetal. Tampoco se presenta mejoría, por lo que se interrumpe embarazo por medio de cesárea. El producto al nacer presenta signos de insuficiencia respiratoria y se recurre a asistencia ventilatoria mecánica con altos parámetros. Persistió el derrame pleural por lo que se realizó drenaje y colocación de tubo de tórax, con evolución poco favorable y muerte neonatal. Actualmente no existe consenso mundial del manejo del hidrotórax fetal asociado o no a hidropesía, se plantean factores a tener en cuenta que guiaran a la decisión de un manejo expectante o intervencionista, basándose en la causa desencadenante. Rev.cienc.biomed. 2010; 2 (1): 121-129
Application of marketing complex in the tourism. Instrumental-methodical apparatus of research
Authors: Sherstiuk Roman , Maliuta Liudmyla , Ratynskyj Vadym
Published: October 2021

Tourism is an important sector that contributes to the development of the country's economy. To gain a larger share of this competitive sector, it is necessary to create more profitable new tourism markets and develop appropriate marketing strategies. This study examines the term niche marketing and niche market definition. The relationship between the marketing niche and other marketing methods is noted and its advantages and disadvantages are outlined. In addition, the application of the niche market in the tourism industry is indicated and the reasons for increasing the practice of marketing niches as a marketing strategy are identified. This study aims to present a concise status of niche marketing and thus create a basis for marketers and researchers. In the modern world community, the tourism industry occupies a very important economic niche. Over the past twenty years, many Western countries have replenished their wealth through the development of this industry. In Ukraine, tourism is not perceived as an independent and equal segment of the economy. The tourism industry is experiencing a period of formation both in the theoretical sense (as a scientific field) and in practice. One of the most important stages of tourism development is the marketing component: research, strategy and planning, but in the field of tourism these stages are given little attention. This fact is a very significant problem, as the growth in demand for tourism services is extensive, and companies selling tourism services have not been adapted to this. Enterprises in the field of tourism are engaged in the development of a new product, programs of various tours, pricing, improving the quality of the tourist product, as well as developments in the sale of such a product and the implementation of local and national marketing concepts. The main and specific role in the support and development of tourism at the international and national levels is played by the state. The experience of different countries shows that the success of tourism development directly depends on how the industry is perceived at the state level, how much it enjoys state support. In a number of countries, state programs have been developed to stimulate inbound tourism, which provide tax benefits, simplification of the customs regime, creating favorable conditions for investment in tourism, increasing budget allocations for infrastructure development, advertising in foreign markets, training of qualified personnel.
Оцінка змін у лісових генетичних резерватах Полтавщини впродовж останніх 35 років
Authors: Syrota O. P.
Published: October 2021

У статті проаналізовано динаміку природних процесів у лісових генетичних резерватах (ЛГР) державних підприємств Полтавського обласного управління лісового та мисливського господарства за авторською методикою комплексного оцінювання з використанням матеріалів лісовпорядкування. Лісівничі показники на час відведення генетичних резерватів порівнювали із сучасними таксаційними показниками ЛГР та оцінили за баловою шкалою. Визначено різницю суми балів двох періодів. Серед 13 обстежених лісових генетичних резерватів у трьох відзначено позитивну динаміку природних процесів, у семи – змін не відбулося, ще в трьох ЛГР помічено незначні негативні зміни. Загалом відзначено позитивну динаміку функціонування ЛГР дуба звичайного, нейтральну – вільхи чорної та зниження показників ЛГР сосни звичайної. Визначено можливості застосування запропонованої методики у подальшій практичній роботі.
Extraction and analysis of oleanolic acid and ursolic acid from apple processing waste materials using ultrasound-assisted extraction technique combined with high performance liquid chromatography
Authors:   Petre Melikishvili Institute of Physical and Organic Chemistry at Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia, RUBASHVILI Imeda , TSITSAGI Mzia ,   Petre Melikishvili Institute of Physical and Organic Chemistry at Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia, ZAUTASHVILI Marine ,   Petre Melikishvili Institute of Physical and Organic Chemistry at Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia, CHKHAIDZE Mariam ,   Petre Melikishvili Institute of Physical and Organic Chemistry at Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia, EBRALIDZE Ketevan ,   Petre Melikishvili Institute of Physical and Organic Chemistry at Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia, TSITSISHVILI Vladimer ,   Petre Melikishvili Institute of Physical and Organic Chemistry at Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia
Published: October 2021

The aim of the present study was to develop a is simple, effective, eco-friendly, reproducible and high-yield two-stage ultrasound-assisted extraction (UAE) procedure combined with quantitative determination high performance liquid chromatographic (HPLC) method for obtaining isomeric triterpene acids - oleanolic acid (OA) and ursolic acid (UA) in the crystalline dried powdered form from apple processing agro-industrial waste material. A rapid, sensitive and specific HPLC method was developed and validated with respect to robustness, specificity, linearity-range, accuracy, precision and sensitivity. The effect of the nature and the volume of the extraction solvent, the extraction time and the sample size on the extraction efficiency were investigated. The optimal conditions for high-yield extraction were found.
Long Time Efficacy and Safety of Microvascular Decompression Combined with Internal Neurolysis for Recurrent Trigeminal Neuralgia
Authors: Zheng Wenhao , Dong Xiaoqiao , Wang Din , Hu Qiang , Du Quan
Published: October 2021

Objective : To explore the clinical efficacy and safety of microvascular decompression (MVD) combined with internal neurolysis (IN) in the treatment of recurrent trigeminal neuralgia (TN) after MVD.Methods : Sixty-four patients with recurrent TN admitted to the hospital from January 2014 to December 2017 were divided into two groups according to the surgical method. Twenty-nine patients, admitted from January 2014 to December 2015, were treated with MVD alone, whereas 35 admitted from January 2016 to December 2017 were treated with MVD+IN. The postoperative efficacy, complications, and pain recurrence rate of the two groups were analyzed.Results : The efficacy of the MVD+IN and MVD groups were 88.6% and 86.2%, and the cure rates were 77.1% and 65.5% respectively. There was no statistically significant difference between the two groups (p>0.05). The cure rate (83.3%) of patients in the MVD+IN group, who were only found thickened arachnoid adhesions during the operation that could not be fully released, was significantly higher than that of the MVD group (30.0%) (p<0.05), while the efficacy (91.7% vs. 70%) of the two groups was not statistically different (p>0.05). For patients whose arachnoid adhesions were completely released, there had no significant difference (p>0.05) in the efficacy (87% vs. 94.7%) and recurrence rate (5.0% vs. 11.1%). The incidence of postoperative facial numbness (88.6%) in the MVD+IN group was higher than that in the MVD group (10.3%) (p<0.01). The long-term incidence of facial numbness was not statistically significant (p>0.05). In the 18–36 months follow-up, the recurrence rate of patients in the MVD+IN group (9.7%) and in the MVD group (16%) were not statistically different (p>0.05).Conclusion : A retrospective comparison of patients with recurrent TN showed that both MVD and MVD combined with IN can effectively treat recurrent TN. Compared with MVD alone, MVD combined with IN can effectively improve the pain cure rate of patients with recurrent TN who have only severe arachnoid adhesions. The combination does not increase the incidence of long-term facial numbness and other complications.
Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix
Authors: Kim Woo Hyun , Min Wongi , Park Kwang Il , Lillehoj Hyun S. , Fernandez-Colorado Cherry P. , Flores Rochelle A. , Cammayo Paula Leona T. , Nguyen Binh Thanh
Published: October 2021

Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.
Genotypes of Echinococcus Species from Cattle in Tanzania
Authors: Bia Mohammed Mebarek , Choe Seongjun , Ndosi Barakaeli Abdieli , Park Hansol , Kang Yeseul , Eamudomkarn Chatanun , Nath Tilak Chandra , Kim Sunmin , Jeon Hyeong-Kyu , Lee Dongmin , Eom Keeseon S.
Published: October 2021

Cystic echinococcosis is a zoonotic parasitic disease caused by Echinococcus species. Tanzania is one of the endemic countries with cystic echinococcosis. This study focussed on identifying genotypes of Echinococcus spp. in Tanzania. We collected 7 cysts from cattle in Mwanza municipal (n=4) and Loliondo district (n=3). The cysts from Mwanza were all E. ortleppi and fertile. In contrast, the cysts from Loliondo were all E. granulosus sensu stricto and sterile. Two from the 4 cysts were a new haplotype of E. ortleppi (G5). These results can improve the preventive and control programs for humans and livestock in Tanzania. To our knowledge, this study is considered the first to identify the genotype and haplotype of Echinococcus spp. in Tanzania.
Geographical Distribution and Epidemiologic Factors of Chigger Mites on Apodemus agrarius during Autumn in Korea
Authors: Lee In Yong , Lim Jae-Won , Seo Jang Hoon , Kim Heung Chul , Lee Ku Jae , Yong Tai-Soon , Lee Won-Ja , Yu Jae-Ran , Sim Seobo
Published: October 2021

A nationwide survey of chigger mites causing scrub typhus and an investigation of epidemiologic factors for chigger mites was conducted at 16 localities in 8 provinces in Korea during autumn 2009, 2012, and 2013. A total of 233 Apodemus agrarius were captured, and all were infested with chigger mites. The chigger index was highest in Chungcheongbuk-do in 2009 (358.3) and 2012 (290.1) and Chungcheongnam-do in 2013 (294.4). The predominant chigger mite species was Leptotrombidium pallidum in the northern and central parts and L. scutellare in the southern and western parts, Korea. L. pallidum was not found in Jellanam-do and Gyeongsangnam-do and the distribution of L. scutellare had been expanded in the northern parts of Korea. The chigger index of L. pallidum was positively correlated with temperature and negatively correlated with humidity. The incidence of scrub typhus is dependent on L. scutellare index. These findings could be helpful to monitor the distribution of chigger mites and to develop a preventive measures for scrub typhus in Korea.
Microbiome of Haemaphysalis longicornis Tick in Korea
Authors: Kim Myungjun , Kim Ju Yeong , Yi Myung-hee , Lee In-Yong , Yong Dongeun , Jeon Bo-Young , Yong Tai-Soon
Published: October 2021

Ticks can transmit pathogenic bacteria, protozoa, and viruses to humans and animals. In this study, we investigated the microbiomes of Haemaphysalis longicornis according to sex and life stages. The Shannon index was significantly higher for nymphs than adult ticks. Principal coordinates analysis showed that the microbiome composition of female adult and male adult ticks were different. Notably, Coxiella-like bacterium (AB001519), known as a tick symbiont, was found in all nymphs and female adult ticks, but only one out of 4 male adult ticks had Coxiella-like bacterium (AB001519). In addition, Rickettsia rickettsii, Coxiella burnetii, and Anaplasma bovis were detected in this study.
Trichinosis Imitating an Inflammatory Systematic Disease
Authors: Kosmidou Maria , Papamichail Georgios , Klouras Eleftherios , Tsamis Konstantinos , Sarmas Ioannis , Rapti Iro , Milionis Haralampos
Published: October 2021

Trichinellosis (trichinosis) is a parasitic infection caused by nematodes of the genus Trichinella. Pigs are the most common source of human infection. We describe a case of a 47-year-old woman presented with a wide range of intermittent symptoms including prolonged fever, dry cough, diarrhea, rash, myalgias and arthralgias. The patient was attended by physicians with various medical specialties such as dermatologists, rheumatologists and allergiologists, but they did not establish a certain diagnosis because of the gradual onset of symptoms, raising the suspicion of a systematic disease. After extensive work up, the diagnosis of trichinosis was established with femoral muscle biopsy compatible with inflammatory myopathy of parasitic etiology with trichinosis to be the predominant diagnosis. Despite the significant delay of diagnosis for almost three months, patient was treated successfully with no further complications. Trichinellosis is a food-borne treatable infection. Preventive measures include community education especially in zones where parasite prevalence is increased, improvement of farming and cooking techniques.
An Epidemiological Analysis of 28 Vivax Malaria Cases in Gimpo-si, Korea, 2020
Authors: Bahk Young Yil , Cho Shin-Hyeong , Kim Kyoung-Nam , Shin Eun-Hee , Jeon Byoung-Hak , Kim Jeong-Hyun , Park Sookkyung , Kwon Jeongran , Kan Hyesu , Kim Miyoung , Kim Tong-Soo
Published: October 2021

Since 1993, vivax malaria has been recognized as a public health burden in Korea. Despite of pan-governmental malaria-control efforts and the dramatic reduction in the burden of this disease over the last 10 years, vivax malaria has not been well controlled and has remained continuously endemic. We focused interviewed and examined the charts of 28 confirmed vivax malaria patients given malarial therapy for whom daily records were kept from Gimpo-si, Gyeonggido of Korea. Various epidemiological characteristics of vivax malaria, including the incubation period, medication used, and recurrence, and an evaluation of the parasitic characteristics from the focused interviews of patients from this region are described here. Most of the participants indicated the 3 most common symptoms of malaria (headache, chills and fever). Of the 28 cases, 2 experienced a second attack and there were 17 and 11 cases with short- and long-term incubation periods, respectively, yielding a short-term to long-term ratio of 1.5. Based on the parasitemia stages, most of the participants were tested at 5 to 7 days (11 cases) and 7 to 15 days (11 cases) after initial wave of asexual parasites. In conclusion, public health authorities should consider developing management measures to decrease the time lag for diagnosis and drafting unified and robust guidelines for drug use for malaria and drawing up unified and robust guidelines on the use of medication for malaria. It also suggests that routine monitoring, surveillance, and precise medical surveys in high-risk vivax malaria endemic areas are pivotal to controlling this persistent public disease and finally eliminating it from Korea.
Awareness and Opinions of Inhabitants on Vivax Malaria in Two Endemic Areas, Gyeonggi-do, Korea
Authors: Bahk Young Yil , Cho Shin-Hyeong , Na Byoung-Kuk , Hong Sung Jong , Lee Sung-Keun , Kim Tong-Soo
Published: October 2021

The incidence of vivax malaria in Korea was reduced to a low plateau. For successful elimination of vivax malaria, socio-behavioral changes in the communities are essential. This study aimed to figure out awareness of the inhabitants on the vivax malaria endemicity. The 407 participants including vivax malaria patients and uninfected inhabitants in Gimpo- and Paju-si, Gyeonggi-do, known as high-risk areas in Korea. We used a community-based study design and non-probability sampling method using primary data. Except for the perception about the public health facilities’ capability to cope with anti-malaria programs, the 2 groups of participants shared the same level of awareness about public promotional and educational measures and opinions for malaria elimination from the community. Thus, our future goals for malaria prevention and elimination are to develop more active and well-organized community-based education and evaluation programs collaborating with the community healthcare authorities and local governments.
Prevalence and Intensity of Opisthorchis viverrini Metacercarial Infection in Fish from Phnom Penh, Takeo, and Kandal Provinces, Cambodia
Authors: Sohn Woon-Mok , Choi Seung-Ho , Jung Bong-Kwang , Hong Sooji , Ryoo Seungwan , Chang Taehee , Lee Keon Hoon , Na Byoung-Kuk , Hong Sung-Jong , Khieu Virak , Chai Jong-Yil
Published: October 2021

The prevalence and intensity of Opisthorchis viverrini metacercariae (OvMc) were investigated in fish from 3 southern administrative regions along the Mekong River in Cambodia, i.e., Phnom Penh, Takeo, and Kandal Provinces from 2017 to 2020. A total of 295 freshwater fish (24 species) were transported to our laboratory with ice and examined using the artificial digestion method. In Phnom Penh, among 4 fish species positive for OvMc, 9 (23.7%) of 38 specimens examined were infected, and their intensity of infection averaged 4.3 metacercariae per infected fish. In Takeo Province, among 10 fish species positive for OvMc, 24 (38.1%) out of 63 fish examined were infected, and their intensity of infection was av. 14.4 metacercariae per infected fish. In particular, all of 3 Osteochilus schlegelii fish examined were infected, and their infection intensity was high, 34.7 metacercariae per fish. In Kandal Province, among 6 fish species positive for OvMc, 46 (90.2%) out of 51 specimens examined were infected, and their infection intensity was 24.0 metacercaraie per infected fish. All fish of Systomus orphoides (n=17), Barbonymus altus (n=14), and Rasbora aurotaenia (n=2) were infected, and their intensity of infection averaged 37.7, 21.6, and 18.5 metacercariae per fish, respectively. Metacercariae of Haplochis yokogawai, Haplorchis taichui, and Centrocestus formosanus were detected in fish from Takeo and Kandal Provinces. From these results, it has been confirmed that a variety of fish species from Phnom Penh, Takeo, and Kandal Provinces are commonly infected with OvMc, and preventive measures to avoid human O. viverrini infection should be performed in Cambodia.
Grazing of a heterotrophic nanoflagellate on prokaryote and eukaryote prey: ingestion rates and gross growth efficiency
Authors: Corradino GL , Schnetzer A
Published: October 2021

Heterotrophic nanoflagellates (HNANs) play a pivotal role as consumers of picoplankton, remineralizers and carbon vectors, yet knowledge on how prey quantity and quality affect HNAN physiology remains limited. In a series of grazing experiments using an uncharacterized member of the HNAN assemblage, we found that growth (μ) and ingestion rate (IR) varied when offering heterotrophic bacteria (HB), Synechococcus spp. (Syn), Ostreococcus lucimarinus (Ost) or a combination of all 3 prey types. Highest average μ rates (1.8 d-1) were detected on HB at densities of ~106 cells ml-1 and maximum IR on Syn (485 pg C d-1) at ~106 cells ml-1. Independent of prey type, flagellate μ increased with IR up to ~50 pg C d-1. A relatively low P-content in Ost was linked to shifts in C:N:P ratios of the HNAN in the single-prey experiment and when Ost was offered as part of the mixed assemblage. Presented with a mixed diet, the highest contribution to daily C intake came from Ost with 50%, followed by HB with 46% and Syn with only 4%. C-based gross growth efficiencies (GGEs) were higher when feeding on HB and mixed prey, compared to both picophototrophs, while N- and P-based GGEs in mixed prey treatments markedly exceeded those when feeding on any single prey. The findings in this study corroborate the importance of investigating the biogeochemical role of HNANs in relation to prey availability and quality to refine estimates of energy transfer within the microbial loop.
Medieval Traditions, New Technologies: Linked Open Geodata and Burchard of Mount Sion's Descriptio terrae sanctae
Authors: O'Doherty Marianne
Published: October 2021

This article experiments with using the Pelagios Linked Open data infrastructure and its annotation tool Recogito to explore the geographical framework of Burchard of Mount Sion's thirteenth-century Descriptio terrae sanctae. It places Burchard's text in the context of medieval practices of linking information intertextually and illuminates the roles played by geographical intertextual links in the text's conceptual geography. In particular, it explores the functions of geographical links to Old Testament books of the Deuteronomic History in the Descriptio, and explores Burchard's methods in using geographical links to harmonize the different textual traditions and geographical frameworks on which the Descriptio draws and to give meaning to the landscape he describes. Overall, the article shows the usefulness of infrastructures such as Pelagios and platforms such as Recogito, alongside more traditional methods of textual and source analysis, in illuminating the geographical framework of a complex medieval text. It highlights some of the difficulties in using such infrastructures to grapple with the complexities of medieval geographical frameworks, while noting some recent developments in digital mapping technologies that may help to address these.
Victorian400: Colorizing Victorian Illustrations
Authors: Kim Hoyeol
Published: October 2021

This article introduces the Victorian400 dataset, created to colorize black-and-white illustrations from nineteenth-century British novels with deep learning models. The Victorian400 dataset is a set of colour illustrations painted using nineteenth-century palettes which have been shared as open sources. This article examines the process of creating and curating the Victorian400 dataset and the validity of the Victorian400 dataset by looking into the results of the test set with the trained set based on conditional generative adversarial networks.
Administrative principles of intellectual property rights protection against unfair competition on the pharmaceutical market in Ukraine
Authors: Volynets Inna
Published: October 2021

Keywords: administrative protection of intellectual property rights, unfair competition,pharmaceutical market, AMCU, NIPA Appeals Chamber, post-grant opposition,pre-grant opposition

The article is dedicated to study for peculiarities of intellectual propertyrights protection on pharmaceutical market under administrative procedure. Thepaper enlightens importance of balancing the regulation of antitrust and intellectualproperty law, through legislative reform as well. It is emphasized on the specifics ofthe jurisdictional form of rights protection, which is comprised from judicial protectionand administrative protection of infringed intellectual property rights. The authordenotes that the administrative procedure is a special form of protection, whichinvolves appealing to government agencies for violated rights protection. The studyuncovers the following main state bodies, entrusted with the relevant functions andwhich consider applications on measures for violated rights protection: The AntimonopolyCommittee of Ukraine and the Appeals Chamber of the National IntellectualProperty Authority (NIPA Appeals Chamber). It is stated that the AntimonopolyCommittee of Ukraine is qualified to consider offences in terms of protection againstunfair competition, respectively, the NIPA Appeals Chamber considers objectionsagainst the National Intellectual Property Authority, appeals and applications forrecognition of the trademark to be well-known in Ukraine. Emphasis is placed on themechanisms of «post-grant opposition» (recognition of rights to inventions (utilitymodel), industrial designs invalid) by the NIPA Appeals Chamber and «pre-grant opposition» (possibility of appealing decisions by third party to the NIPA Appeals Chamber).It is proved that the NIPA Appeals Chamber is a competent and qualified bodyin the intellectual property field, enabled to protect intellectual property rights, includingagainst «patent trolling», «evergreen» patents and counteract indirectly withunfair competition. The paper proves that the administrative procedure for the intellectualproperty rights protection is speedier than the judicial procedure, but is as effectiveand efficient as judicial protection.
Why African Norms Matter: Subsidiarity and Agency in Peacemaking
Authors: Ifediora Obinna
Published: October 2021

This article explains the problem facing the UN and African regional organizations in applying the principle of subsidiarity in peacemaking. It draws on the concept of norm subsidiarity and examines African norm-setting instruments. It argues that the African Union is a subsidiary actor in the global order, making parallel but distinct norms to export globally, retain autonomy, claim primacy, and deflect implementing uncomfortable external principles. Conversely, African subregional organizations are localizing actors, willing to accept or modify global and regional rules. The significance is that existing studies assume that the AU is or should be a localizing agent, as Chapter VIII of the UN Charter anticipated. Essentially, current studies have subsumed African norms under international rules, denying the importance of African rule-making power. This study shows that African norms underpin subsidiarity and agency in peacemaking and therefore matter. This article contributes to the scholarship on African agency in international relations.
Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications
Authors: Lyu Ping , Li Bo , Li Peiran , Bi Ruiye , Cui Chen , Zhao Zhihe , Zhou Xuedong , Fan Yi
Published: October 2021

Parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) are two peptides that regulate mineral ion homeostasis, skeletal development, and bone turnover by activating parathyroid hormone 1 receptor (PTH1R). PTH1R signaling is of profound clinical interest for its potential to stimulate bone formation and regeneration. Recent pre-clinical animal studies and clinical trials have investigated the effects of PTH and PTHrP analogs in the orofacial region. Dental mesenchymal stem cells (MSCs) are targets of PTH1R signaling and have long been known as major factors in tissue repair and regeneration. Previous studies have begun to reveal important roles for PTH1R signaling in modulating the proliferation and differentiation of MSCs in the orofacial region. A better understanding of the molecular networks and underlying mechanisms for modulating MSCs in dental diseases will pave the way for the therapeutic applications of PTH and PTHrP in the future. Here we review recent studies involving dental MSCs, focusing on relationships with PTH1R. We also summarize recent basic and clinical observations of PTH and PTHrP treatment to help understand their use in MSCs-based dental and bone regeneration.
Characteristics and Origin of Organic Matter in Triassic Lacustrine Shale From Fuxian Oilfield
Authors: Bojiang Fan
Published: October 2021

Along with the successful exploitation of shale oil, organic-rich shale has attracted great attention to the geologists. However, quantitatively differentiating the origin of organic matter in shale is still challenging due to the nature of its complex depositional processes. Organic matter in lacustrine shales could be derived from both lake water (produced by lake water column) and land input (transported into the lake by rivers). The Triassic Chang-7 shale in the Yanchang Formation is a typical lacustrine shale deposited in the central part of the Ordos Basin. It is rich in organic matter (TOC of 0.52−9.37%) and consists primarily of type II1 kerogen. The Chang-7 shale is thermally mature and currently in the stage of generating oil and gas, with more structured than organic matter. In this study, quantitative models of organic matter in the Chang-7 shale with sources from both lake water and land is established using geochemical and carbon isotopes data and the results show that lake water and land input have the almost equal contribution to the organic enrichment in the study area.