bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal osteodystrophy and clinical outcomes: a prospective cohort study
Authors: Carbonara Cinthia Esbrile Moraes , Barreto Joaquim , Roza Noemi Angelica Vieira , Quadros KélciaRosana da Silva , Reis Luciene Machado dos , Carvalho Aluízio Barbosa de , Sposito Andrei C. , Jorgetti Vanda , Oliveira Rodrigo Bueno de
Published: October 2023

Abstract Introduction: Renal osteodystrophy (ROD) refers to a group of bone morphological patterns that derive from distinct pathophysiological mechanisms. Whether the ROD subtypes influence long-term outcomes is unknown. Our objective was to explore the relationship between ROD and clinical outcomes. Methods: This study is a subanalysis of the Brazilian Registry of Bone Biopsies (REBRABO). Samples from individual patients were classified as having osteitis fibrosa (OF), mixed uremic osteodystrophy (MUO), adynamic bone disease (ABD), osteomalacia (OM), normal/minor alterations, and according to turnover/mineralization/volume (TMV) system. Patients were followed for 3.4 yrs. Clinical outcomes were: bone fractures, hospitalization, major adverse cardiovascular events (MACE), and death. Results: We enrolled 275 participants, of which 248 (90%) were on dialysis. At follow-up, 28 bone fractures, 97 hospitalizations, 44 MACE, and 70 deaths were recorded. ROD subtypes were not related to outcomes. Conclusion: The incidence of clinical outcomes did not differ between the types of ROD.
Osteodistrofia renal e desfechos clínicos: um estudo de coorte prospectivo
Authors: Carbonara Cinthia Esbrile Moraes , Barreto Joaquim , Roza Noemi Angelica Vieira , Quadros KélciaRosana da Silva , Reis Luciene Machado dos , Carvalho Aluízio Barbosa de , Sposito Andrei C. , Jorgetti Vanda , Oliveira Rodrigo Bueno de
Published: October 2023

Resumo Introdução: Osteodistrofia renal (OR) refere-se a um grupo de padrões morfológicos ósseos que decorrem de mecanismos fisiopatológicos distintos. É desconhecido se os subtipos de OR influenciam desfechos em longo prazo. Nosso objetivo foi explorar as relações entre OR e desfechos. Métodos: Este estudo é uma subanálise do Registro Brasileiro de Biópsias Ósseas (REBRABO). As amostras de cada paciente foram classificadas em osteíte fibrosa (OF), osteodistrofia urêmica mista (MUO), doença óssea adinâmica (ABD), osteomalácia (OM), alterações normais/menores, e pelo sistema Remodelação / Mineralização / Volume (RMV). Os pacientes foram acompanhados por 3,4 anos. Os eventos clínicos foram: fraturas ósseas, hospitalizações, eventos cardiovasculares adversos maiores (MACE), e óbito. Resultados: Analisamos 275 indivíduos, 248 (90%) deles estavam em diálise. No acompanhamento, 28 fraturas ósseas, 97 hospitalizações, 44 MACE e 70 óbitos foram registrados. Os subtipos de OR não foram relacionados aos desfechos clínicos. Conclusão: A incidência de desfechos clínicos não diferiu entre os tipos de OR.
Effects of COVID-19 on diaphragm thickness and physical performance of athletes
Authors: Farias Alliny Souza , Soloaga Aline Ortega , Rezende Luiz Carlos , Zanatto Sander Fric , Silva Vanessa Mandú da , Coelho-Ravagnani Christianne de Faria
Published: October 2023

Abstract Introduction Studies suggest that diaphragm thickness (DT) is associated with inspiratory muscle strength and consequently, better ventilatory and mechanical efficiency. On the other hand, infectious diseases such as COVID-19 may impact the structure and function of the respiratory system. Objective Assess the association between DT and the physical performance (PP) of athletes and the effects of COVID-19 infection on these parameters. Methods This is a cross-sectional study of 63 athletes of both sexes from different sport modalities (women: 16.67 ± 5.03 years, 52.09 ± 14.01 kg, 155.90 ± 13.86 cm; men: 23.44 ± 9.65 years, 72.24 ± 14.18 kg, 174.84 ± 6.84 cm), submitted to DT assessment using ultrasound, followed by the PP(Yo-Yo) test) to determine maximum oxygen intake (VO2max). Pearson’s correlation was used to determine the association between VO2max and DT, and the Student’s t-test for differences between athletes with a positive and negative diagnosis for COVID-19. The significance level was set at 5%. Results There was no association between DT and PP (r = 0.30 and p = 0.22) or between athletes unaffected and affected by COVID-19 in relation to DT (57.00 ± 0.26 vs 52.00 ± 0.25%; p = 0.91) and PP (43.88 ± 2.29 vs 38.34 ± 13.61 ml/kg/min; p = 0.69). Conclusion DT was not associated with maximum oxygen intake in athletes. In addition, athletes infected by COVID-19 exhibited no differences in VO2max or DT when compared to nonaffected individuals.
WHAT WAS THE COVID-19 PANDEMIC’S IMPACT ON HUMAN RESOURCE MANAGEMENT AND WORK? AN INTEGRATIVE LITERATURE REVIEW
Authors: Presti Michael Joseph , Mendes Diego Costa
Published: October 2023

ABSTRACT Considering the pandemic's wide-ranging impacts, this study examined how the literature addressed its effects on work, human resource management (HRM), and organizations. Sixty-four articles published between January 2020 and March 2022 were systematically selected for this bibliographic review. A thematic content analysis was conducted, categorizing the most frequently discussed topics into three argumentative categories: work and workers, HRM, and organizations. These categories revealed convergences, divergences, and gaps in the literature, leading to the conclusion that values such as autonomy, flexibility, and communication were essential across all three categories. Telework emerged as the predominant work modality, requiring profound adaptations to HRM processes. Notably, geographic, socioeconomic, and demographic factors influenced teleworkers' assessments and productivity, warranting further investigation. The pandemic underscored a paradigm shift in recruitment and professional categorization, highlighting the importance of adaptable proficiencies in remote work, encompassing both technical and interpersonal skills, during and after the crisis. Lastly, organizations responded by strengthening flexible and empathetic organizational cultures capable of withstanding the biopsychosocial pressures experienced by workers during the pandemic.
QUAL O IMPACTO DA PANDEMIA DE COVID-19 NA GESTÃO DE PESSOAS E NO TRABALHO? UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Presti Michael Joseph , Mendes Diego Costa
Published: October 2023

RESUMO Considerando os impactos abrangentes da pandemia de Covid-19, este estudo teve como objetivo examinar a forma como a literatura abordou os efeitos da pandemia no trabalho, na gestão de pessoas (GP) e nas organizações. Para esta revisão bibliográfica, foram selecionados sistematicamente 64 artigos publicados entre janeiro de 2020 e março de 2022. Foi realizada uma análise de conteúdo temática, categorizando os tópicos mais frequentemente discutidos em três categorias argumentativas: trabalho e trabalhadores, GP e organizações. Essas categorias revelaram convergências, divergências e lacunas na literatura, chegando-se à conclusão de que valores como autonomia, flexibilidade e comunicação eram essenciais nas três categorias. O teletrabalho emergiu como a modalidade de trabalho predominante, exigindo adaptações profundas nos processos de GP. Ademais, fatores geográficos, socioeconômicos e demográficos influenciaram significativamente as avaliações e a produtividade dos teletrabalhadores, o que justifica uma investigação mais aprofundada. A pandemia evidenciou uma mudança de paradigma na contratação e na categorização profissional, ressaltando a importância de competências adaptáveis no contexto do trabalho remoto, abrangendo tanto habilidades técnicas quanto interpessoais, durante e após a crise. Por fim, as organizações responderam fortalecendo culturas organizacionais flexíveis e empáticas, capazes de lidar com as pressões biopsicossociais enfrentadas pelos trabalhadores durante a pandemia.
CAPACIDADE DE ABSORÇÃO POTENCIAL E REALIZADA: UMA ANÁLISE EM TIMES DE PROJETO
Authors: Gonzalez Rodrigo Valio Dominguez
Published: October 2023

RESUMO A capacidade de absorção (ACAP) é um fator fundamental para a firma alcançar capacidade dinâmica e vantagem competitiva. Estudos prévios identificam duas dimensões que compõem esse constructo, denominadas capacidade de absorção potencial (PACAP) e capacidade de absorção realizada (RACAP). Este estudo investiga a influência das duas dimensões da ACAP em relação à performance e inovação de projeto, e também analisa o papel mediador que a RACAP exerce na relação entre a PACAP e performance e inovação de projeto. Este estudo explora essas relações a partir do método de modelagem de equação estrutural (SEM), utilizando a abordagem de mínimos quadrados parciais (PLS), aplicado a uma amostra de 128 empresas do setor automobilístico fabricantes de componentes automotivos. Os resultados mostram que a performance e a inovação do projeto são impactadas de maneira distinta pela PACAP e RACAP. Além disso, o estudo aponta que a RACAP exerce papel mediador nas relações entre a PACAP e a performance e inovação do projeto.
A ponta do iceberg: o teletrabalho durante a pandemia
Authors: Antunes Evelise Dias , Ribeiro Bruno Chapadeiro , Santos Marta , Fischer Frida Marina
Published: October 2023

Resumo A pandemia do novo coronavírus levou o trabalho para a residência de milhares de trabalhadores no mundo, de maneira compulsória. Portanto, este ensaio objetiva evidenciar os fatores psicossociais de riscos à saúde e o panorama do teletrabalho no primeiro ano da pandemia de covid-19 e, neste contexto, analisar a política do teletrabalho no Brasil. Apresentamos os diferentes conceitos do teletrabalho e discutimos sobre como não é uma modalidade ausente de riscos. Fatores psicossociais, como o isolamento social e profissional, a intensificação do trabalho e sobreposição de atividades profissionais e familiares são alguns dos destacados na literatura. A partir de dados secundários obtidos da Pesquisa Nacional por Amostra de Domicílios e análises do Instituto de Pesquisa Econômica Aplicada durante a pandemia, revelou-se um panorama de desigualdade no perfil daqueles que tem acesso ao teletrabalho, além da acentuação das diferenças regionais. Por fim, identificamos um descompasso entre a regulamentação do teletrabalho e as necessidades dos trabalhadores, impactadas pela pandemia de covid-19. Assim, é necessária a elaboração, reformulação e implementação de políticas, visando garantir os direitos e saúde dos teletrabalhadores.
“Pessoa com deficiência” e “pessoa sem deficiência” na escola para todos: um convite à suspensão
Authors: Ramos Eliane de Souza , Lanuti José Eduardo de Oliveira Evangelista
Published: October 2023

RESUMO As expressões “pessoa com deficiência” e “pessoa sem deficiência” têm sido utilizadas na escola comum para identificar os alunos. Uma escola para todos é aquela que considera a diferença e a singularidade de cada estudante e que não recorre a categorias que os inferiorizam para representá-los. Consideramos o Atendimento Educacional Especializado essencial no estudo das situações inacessíveis que têm justificado a imposição da deficiência a alguns alunos. Propomos neste artigo o uso comprometido e consciente de documentos legais que categorizam os alunos que são público-alvo da Educação Especial, com o intuito de assegurar a cada um deles o direito à Educação. No entanto, sugerimos que a escola comum procure suspender as categorias quando planeja e desenvolve o trabalho educacional e pedagógico. Com isso haveria, ainda que momentaneamente, uma transferência da “deficiência” atribuída aos alunos às situações inacessíveis que os atingem.
As políticas de avaliação da pesquisa e da pós-graduação nos Países Baixos: lições sobre autoavaliação e autonomia institucional
Authors: Trevisol Joviles Vitório , Brasil André
Published: October 2023

RESUMO Este artigo apresenta os resultados de um estudo sobre o sistema de avaliação da pesquisa e da pós-graduação dos Países Baixos. As políticas implementadas ao longo das últimas quatro décadas consolidaram um sistema sui generis e estável de avaliação, contribuindo para fortalecer a liderança científica do país no cenário internacional. A experiência holandesa tem inspirado diversos países e suas lições também podem ser relevantes para a realidade brasileira. Nesse contexto, este estudo visou analisar as principais características do sistema holandês; compreender o papel da autoavaliação no sistema e apresentar uma experiência de autoavaliação desenvolvida por um notável centro de pesquisa da Universidade de Leiden. Com base nas lições apreendidas, concluímos apresentando alguns subsídios para o aprimoramento do sistema brasileiro de avaliação da pós-graduação.
Identidade negra/quilombola: diálogos intergeracionais de autoafirmação em uma comunidade do sertão nordestino
Authors: Nascimento Maria Thaís Mota do , Libardi Suzana Santos
Published: October 2023

RESUMO Este trabalho registra pesquisa realizada com crianças, pré-adolescentes e idosos quilombolas, voltando-se à seguinte temática: processos de construção e autoafirmação das identidades negra e quilombola. O objetivo foi conhecer alguns elementos raciais e culturais evocados por esses indivíduos, ressaltando as relações entre identidade racial e identidade quilombola, a fim de compreender como tais construções sociais se relacionam e como são manejadas por sujeitos de diferentes gerações. A pesquisa foi realizada na comunidade quilombola Serra das Viúvas (Alagoas). Trata-se de uma pesquisa de cunho qualitativo, com realização de oficinas inspiradas nos grupos focais. Participaram dois idosos e 37 crianças e pré-adolescentes. Os resultados demonstraram elementos geracionais da autoafirmação racial, bem como do ser quilombola, apresentados diferentemente pelos/as participantes mais velhos/as e mais jovens.
Extensão universitária na pandemia: tecnologias digitais para o ensino de eficiência energética e proteção climática
Authors: Souza Ruana Tomaz de , Madruga Kátia Cilene Rodrigues , Geremias Reginaldo , Knöpker Mônica
Published: October 2023

Resumo Esta pesquisa objetivou avaliar a implementação de uma iniciativa de extensão universitária, envolvendo tecnologias digitais, voltada à sensibilização de estudantes dos anos finais do ensino fundamental para o uso racional de energia e a proteção climática, realizada no contexto da pandemia de Covid-19. Para tanto, desenvolveu-se um minicurso, ministrado de forma remota, do qual participaram vinte alunos, com idade entre 10 e 13 anos, matriculados em escolas da rede estadual de Santa Catarina, localizadas na cidade de Araranguá. Para esse minicurso, elaboraram-se materiais didáticos, cujos temas foram os seguintes: a) fontes de energia e emissões, b) energia para o transporte e emissões e c) eficiência energética e proteção climática. A partir dos dados coletados, verificou-se que a abordagem de temas relacionados à eficiência energética e à proteção climática pode contribuir para o desenvolvimento de percepções voltadas à redução de impactos sobre o meio ambiente. Identificou-se também a importância desses temas serem abordados de forma contextualizada, como proposto no minicurso, tanto por facilitar a aprendizagem dos estudantes quanto por favorecer que eles levem para suas famílias saberes importantes sobre o papel de cada um na proteção ambiental. Pode-se concluir, portanto, que a extensão universitária se mostra como uma oportunidade para aproximar escolas e academia na construção de metodologias que levem ao ensino e ao aprendizado de diferentes assuntos e, quiçá, à adoção de novos hábitos, especialmente no caso da educação ambiental. Ademais, concluiu-se que as tecnologias digitais são ferramentas potentes na realização de iniciativas de extensão em contextos pandêmicos.
Becoming individuals: processes of individualization and reflexivity
Authors: Colombo Enzo
Published: October 2023

Abstract The article aims to show how young adults (starting with empirical research in Italy, but with the aspiration to highlight more diffuse phenomena among youth growing in the constant experience of the ‘crisis’) face the widespread injunction to be active, creative, flexible, and independent, that is, to be entrepreneurs of themselves. Young people born at the end of the last century have grown up in the midst of continuous crises – economic, health, and geopolitical – which have accentuated the tension between the social drive for personal autonomy and a growing awareness of the inability to individually solve problems that are systemic. Although the pressure to develop an entrepreneurial self and to internalize the drive for individualization may overlap with the development of a form of individualism, they can also promote new forms of sociation, based on sharing and cooperation. These forms are strongly supported by dialogical reflexivity, that is, by social conditions that promote processes of innovation and change stemming from common actions and constant confrontation with different points of view. Introducing the concept of dialogic reflexivity, the article analyses the practices that young adults put in place to support forms of individualization released from mere individualism and how social research and public policies can foster reflexive processes and create favourable conditions for youth participation and inclusion.
Subnational certification of elimination of mother-to-child transmission of HIV and/or syphilis: a Brazilian experience report
Authors: Miranda Angélica Espinosa , Gaspar Pâmela Cristina , Lannoy Leonor Henriette de , Guarabyra Aranaí Sampaio Diniz , Souto Rayone Moreira Costa Veloso , Pereira Esdras Daniel dos Santos , Pereira Gerson Fernando , Dias Guilherme Borges , Domingues Carmen Silvia Bruniera , Lima Aparecida Morais , Matos Ariane Tiago Bernardo de , Oliveira Maria da Guia de , Aragón Mayra Gonçalves , Machado Nádia Maria da Silva , Aires Junior Luíz Fernando , Souza Isabella Mayara Diana de , Maciel Ethel Leonor , Barreira Draurio
Published: October 2023

Abstract Objective: to describe the subnational implementation process of the certification for elimination of mother-to-child transmission of HIV and/or syphilis, its main barriers, challenges and opportunities. Methods: in 2022, indicators from the last full year for impact targets and the last two full years for process targets, available in national information systems, were evaluated; descriptive reports were analyzed and actions were acknowledged within four thematic axes, according to PAHO/WHO recommendations. Results: 43 municipalities ≥ 100,000 inhabitants were certified, covering 24.6 million inhabitants; one municipality achieved dual elimination (HIV-syphilis), 28 municipalities achieved elimination of HIV and 10 received silver tiers; regarding syphilis, one elimination was observed, along with 4 gold tiers, 13 silver tiers and 4 bronze tiers; a higher number of certifications was identified in the Southeast and South regions. Conclusion: barriers and challenges of the process were overcome through tripartite collaboration; the experience provided better integration of surveillance with care and improved actions aimed at preventing mother-to-child transmission.
Multimorbidade e uso de serviços de saúde na população brasileira: Pesquisa Nacional de Saúde 2019
Authors: Souza Ana Sara Semeão de
Published: October 2023

RESUMO Objetivo Descrever a prevalência do uso de serviços de saúde por multimorbidade segundo características sociodemográficas e saúde da população brasileira, e analisar a relação entre a multimorbidade e o uso de serviços de saúde. Métodos Estudo transversal utilizando dados da Pesquisa Nacional de Saúde 2019. Os desfechos foram busca por serviços de saúde nos últimos 15 dias, consulta médica e internações nos últimos 12 meses. Multimorbidade foi definida como ≥ 2 doenças crônicas. As associações foram avaliadas pela regressão de Poisson. Resultados Dos 81.768 indivíduos, a prevalência de busca por serviços de saúde entre indivíduos com multimorbidade foi 38% maior (IC95% 1,31;1,45), consultas médicas, 11% maior (IC95% 1,10;1,12), e 56% maior para internações (IC95% 1,44;1,70), em comparação àqueles sem multimorbidade. Essa relação foi maior para busca e consultas médicas no sexo masculino. Conclusão O uso de serviços de saúde foi maior entre aqueles com multimorbidade, mas diferente entre os tipos de serviços de saúde utilizados e sexos.
Maternal mortality in Northeast Brazil 2009-2019: spatial distribution, trend and associated factors
Authors: Oliveira Ianne Vitória Gomes , Maranhão Thatiana Araújo , Sousa George Jó Bezerra , Silva Taynara Lais , Rocha Maria Izabel Félix , Frota Maria Madalena Cardoso da , Araujo Thalis Kennedy Azevedo de , Pereira Maria Lúcia Duarte
Published: October 2023

Abstract Objective: To analyze the spatio-temporal pattern of maternal mortality and associated factors in Northeast Brazil, from 2009 to 2019. Methods: This was an ecological study using the joinpoint method for temporal analysis and spatial autocorrelation and scan tests to identify clusters; regression models using the ordinary least squares and geographically weighted regression methods were used to identify factors associated with mortality, considering p-value < 0.05. Results: Maternal mortality decreased by 1.5% (95%CI; -2.5;-0.5) per year (p-value = 0.009); clusters, of deaths were found, mainly in Piauí and Maranhão, the variables associated with the maternal mortality ratio were Gini Index (β = 105.72; p-value < 0.001), municipal human development index (β = 190.91; p-value = 0.001), per capita income (β = -0.08; p-value = 0.001), Firjan Municipal Development Index-Health (β = -51.28; p-value < 0.001), life expectancy at birth (β = -3.50; p-value < 0.001). Conclusion: There was a reduction in mortality in the period studied, with a concentration of deaths, primarily in Piauí and Maranhão; socioeconomic indicators were associated with higher mortality in the region.
Reproductive biology of the silky shark Carcharhinus falciformis (Müller & Henle, 1839) in waters off Côte d’Ivoire (West Africa)
Authors: N’Gouan Koua Clément , Konan Kouadio Justin , Kouamé Kouassi Yves Narcisse , Edia Oi Edia
Published: October 2023

Since 2008, the quantity and size of silky shark, Carcharhinus falciformis decrease drastically in catches of artisanal driftnet fishery operating in the coastal waters off Côte d’Ivoire. The objective of this study was to describe the reproductive biology of this species, based on 336 specimens (162 males and 174 females). The total length (TL) of males and female ranged from 81–242 and 79–254 cm respectively. The sex ratio was 0.89:1 (M:F) and 0.93:1 (M:F) in embryos and adults respectively. Males of >180 cm had calciﬁed clasper (17–35 cm) whereas females of >190 cm had oviduct gland length of 18–47 mm. The estimated length at first maturity was 182.8 cm for males and 195.2 cm for females. The range in litter size of three gravid females was 7–9, with an average of 8 embryos of 52–54.5 cm TL were collected in August and December. However, the absence of neonates and scars on females' body, as well as ovulating and differentiating females in catches does not allow a clear determination of its reproductive period in Ivorian waters and therefore, additional research including histological analysis is necessary to better understand the process of spawning of silky shark.
Determining overwintering performance and economic viability of monosex tilapia fingerling production in hapa cum cage aquaculture system for Bangladesh's haor fishers
Authors: Bhuiya Shahidul Islam , Mondal Roni Chandra , Kabeer Fozlul , Alam AKM Nowsad
Published: October 2023

Ensuring a consistent supply of uniformly sized fingerlings for tilapia cage aquaculture in Bangladesh's poses a significant challenge. This study assessed overwintering growth performance and economic viability of monosex tilapia fingerling production in haor waters. Nine hapas, each inside a designated treatment cage, were stocked with T1 (200), T2 (250) and T3 (300) tilapia fry, averaging 1.25±0.25 g, per m³ for 90 days. The most successful treatment continued for two subsequent crops over two years for economic viability assessment. Average final body weight gain was the highest at the lowest stocking density (T1, 58.86±7.23 g), but the most desirable biomass gain (222 kg cage⁻¹) occurred at medium stocking density (T2). Beyond biomass gain, T2 exhibited superior profitability, with 26% and 30% profitability in the second and third crops respectively, over total costs. In conclusion, overwintering tilapia fingerling production in the hapa-cum-cage system at a stocking density of 250 m⁻³ proved more profitable and sustainable than other treatments, offering a viable income-generating option for resource-poor haor fishers.
La Amnistía como Medida Jurídica que Contribuye al Fin del Conflicto Interno Armado - Caso Colombiano
Authors: Bastidas Zárate Juan Sebastián , Pardo Casallas Lili Dayana
Published: October 2023

En el presente artículo se realiza el estudio de la figura jurídica de la amnistía, entendida como un mecanismo complementario para la consecución de la paz, reconciliación y la materialización de la justicia en sentido amplio, en los procesos de transición, desdibujando el imaginario de su relación directa con la impunidad, ilegalidad, ilegitimidad y transgresión de las obligaciones de los estados. Para ello se inicia con la conceptualización de la amnistía, la relación de esta medida jurídica con el cumplimiento de las obligaciones de los estados, la implicación de estas, en la ejecución de la amnistía, su contraste con la impunidad y control de convencionalidad. Así como también el estudio del concepto desarrollado por la CIDH de amnistía e impunidad a través del análisis de sus casos emblemáticos, la legitimidad de las amnistías en procesos de justicia transicional y finalmente la viabilidad y parámetros mínimos de la amnistía para su aplicación en paralelo con el estudio del caso colombiano.
Antecedentes Históricos del Diferendo Limítrofe Colombo Nicaragüense y de la Gestión de la Reserva Biósfera Seaflower
Authors: Álvarez Restrepo Julián Andrés
Published: October 2023

Este artículo tiene como objetivo Identificar los antecedentes históricos de la controversia jurídica de delimitación marítima entre Colombia y Nicaragua, así como las problemáticas en la Gestión Ambiental de la Reserva Biosfera Seaflower,  a partir del Método institucional de la Ciencia Política , que permite entender los antecedentes del diferendo limítrofe entre estos dos Estados más allá de los instrumentos de Derecho Internacional Público y de los Tratados Bilaterales que se celebraron en su momento para adjudicar la Soberanía sobre la Costa de Mosquitos a favor de Nicaragua y del Archipiélago de San Andrés Providencia y Santa Catalina a favor de Colombia. Así las cosas, este texto no se limita solo a la descripción de hechos históricos, sino que hace una hermenéutica de las relaciones de poder entre Colombia y Nicaragua y su disputa por el Archipiélago de San Andrés, Providencia y Santa Catalina, además se centra en la importancia ambiental del área marina protegida declarada Reserva Biósfera Seaflower por la UNESCO en el año 2000, permitiendo evidenciar como resultado y conclusiones que tanto Nicaragua como Colombia deben trascender de un asunto limítrofe a la creación de una Reserva Biósfera Transfronteriza de importancia para el Caribe y el mundo, a partir de la Estrategia de Sevilla + 20.
Progressive Muscle Relaxation: Can it Reduce Competitive Anxiety?
Authors: Jannah Miftakhul , Widohardhono Rachman , Kencana Navylia Tirta
Published: October 2023

The study purpose was to determine the effect of progressive muscle relaxation training on reducing competitive anxiety among shooting athletes. Materials and methods. An experimental approach with a pretest-posttest control group design was used in this study. The experiment was carried out eight times. A total of 12 athletes, 8 males and 4 females, who were shooting athletes, took part in this research. The athletes in this study, who joined the regional training center in East Java Province, Indonesia, ranged in age from 20 to 44 years. In this investigation, saturated samples, including those from all individuals, were used. Data were obtained from competitive anxiety scales during the pre- and post-test periods. Independent samples t-tests were used to assess the data. Results. The t-value for this study is -14,210, and the p-value is 0.001. These findings suggest that progressive muscle relaxation training reduces competitive anxiety in shooting athletes. The athlete’s awareness of the value of mental training contributes to reduction in competitive anxiety. This study has gained traction since athletes are aware of the value of preparing for training before competing because they attend and participate in the regional training center. Conclusions. Progressive muscle relaxation training can be used as an intervention to help shooting athletes reduce their competitive anxiety.
Immunohistochemistry v1
Authors: E Nielsen Beatriz
Published: October 2023

This protocol describes the steps for performing immunohistochemistry.
Acute Brain Slices v1
Authors: E Nielsen Beatriz
Published: October 2023

This protocol describes the steps for preparing acute brain slices.
Model building and refinement of RCKW and FL-LRRK2 bound to inhibitors v1
Authors: Sanz Murillo Marta
Published: October 2023

Protocol to model and refine a PDB against a cryo-EM map.
6-OHDA mouse model of Parkinson's disease v1
Authors: E Nielsen Beatriz
Published: October 2023

This protocol describes the steps for generating a 6-hydroxy-dopamine (6-OHDA) mouse model of Parkinson's disease. Low or high doses of 6-OHDA are injected into the medial forebrain bundle to induce a partial or a more complete dopaminergic lesion respectively.
Dough Rise Assay v1
Authors: Kruglyak Natalie , Li Erin , R Swichkow Chantle
Published: October 2023

This protocol presents an accessible method for actively evaluating dough rise phenotypes in various yeast strains and yeast/bacteria combinations. As dough rise is a pivotal element in bread-making, this approach simplifies assessing the influence of genetic background on dough rise, particularly in non-food science laboratories and educational settings. The process begins by inoculating a sterile dough matrix with yeast and bacteria cultures in a graduated container. The graduations allow for accessible quantification of dough rise over 24 hours. The mixture's height is monitored over time, offering valuable insights into the dynamics of dough rise. This data allows for an active analysis of dough rise dynamics. This protocol is a valuable tool for actively assessing the leavening potential of yeast strains in a controlled and reproducible environment. It actively streamlines the selection of yeast strains that positively impact dough rise, thereby benefiting both the baking industry and sustainability goals through the potential reduction of the environmental impact of bread production.
Necesidades y propuestas para la intervención con menores y violencia de género desde la educación
Authors: Hermoso Soto Alicia Eladia
Published: October 2023

En este estudio se pretende ahondar en las ideas formativas de profesionales de la educación que atienden a menores en situación de violencia de género. Se cuenta con un total de 16 participantes de distintos alrededores de la educación. Se valora la experiencia formativa de cada persona de forma individual para identificar necesidades detectadas de la formación cursada y propuestas para futuros profesionales. Se sigue un enfoque fenomenológico feminista centrado en una teoría fundamentada apoyada con software especializado Atlas ti. 22. Los resultados dejan ver necesidades formativas en cuanto a incorporación de enfoque feminista, especificidad en intervención con menores en situación de violencia de género y prácticas reales. Se observa también la formación con la que cuentan, bien procedente de docentes que incorporaban esta perspectiva o de su propia motivación para aprender en este aspecto. Por consiguiente, las propuestas que señalarán se orientarán a la introducción de contenido actualizado en género, contarán con recursos y apoyos especializados, prácticas e intervención multidisciplinar.
Experiencias de Jóvenes en Contextos de Vulnerabilidad Social durante la COVID-19: Narrativas Combinadas con Foto-Elicitación
Authors: Camilli-Trujillo Celia , Fontana-Abad Mónica
Published: October 2023

Es indudable el impacto que ha tenido la pandemia en la población y cómo ha afectado de manera severa a los colectivos más vulnerables, especialmente a los jóvenes en situación de riesgo de exclusión social. El objetivo es comprender a través del uso de la narrativa combinada con metodologías visuales, cómo el COVID-19 ha influido en la vida de los jóvenes expuestos a situaciones de vulnerabilidad social con relación a sus miedos, oportunidades y expectativas en su trayectoria personal, académica y profesional. Mediante una aproximación cualitativa con la participación de 174 jóvenes, 185 fotos y 174 narrativas individuales y 14 co-narrativas fueron analizadas. Las categorías de consecuencias, miedos, oportunidades y expectativas co-ocurrieron con otras siete emergentes, que hacen referencia a las grandes dimensiones y esferas vitales de los jóvenes: (1) laboral: nuevo horizonte en el presente, (2) redibujar la formación, (3) redes sociales-TIC: nuevos vínculos, (4) identidad ¿quién soy? ¿hacia dónde voy? (5) oscuridad y belleza en la pandemia, (6) valor del tiempo, y (7) sentido de pertenencia. Se concluye sobre la capacidad de estos métodos de adentrarse en capas de significado profundas, así como su potencia formativa en la práctica educativa.
Trastuzumab deruxtecan in the treatment of patients with advanced breast cancer with HER2-low expression: Recent studies review
Authors: Kolyadina I. V.
Published: October 2023

The review gives the definition of HER2-low status, shows its clinical and biological role in patients with advanced breast cancer. A unique mechanism of action of trastuzumab deruxtecan and potential for its use in advanced breast cancer with HER2-low expression are described. The key results of the open multicenter phase III DESTINY-Breast04 (DB-04) trial including safety data are presented. Results on the effectiveness of the drug in patients with markers of hormone resistance first presented in 2023 and the place of trastuzumab deruxtecan in the updated ESMO 2023 algorithm of hormone-positive breast cancer treatment are considered.
Epidemiological aspects of the incidence and mortality of cervical cancer (literature review)
Authors: Kulieva G. Z. , Mkrtchyan L. S. , Krikunova L. I. , Ivanov S. A. , Kaprin A. D.
Published: October 2023

A review of domestic and foreign literature was carried out. Statistical analysis of the available literature showed that at present, despite the improvement of screening programs around the world, there is a steady increase in the incidence and mortality of cervical cancer in women of reproductive age with a high percentage of patients with advanced forms, whose proportion is 32 %. The percentage of deaths during the year since the verification of the disease in 2020 was 12.6 %.

In the structure of mortality in the Russian population, malignant diseases occupy the second ranking place, accounting for 13.6 % after diseases of the cardiovascular system – 43.9 %. Diseases of the female reproductive system account for 18.2 %. At the same time, cervical cancer in the overall structure of oncological morbidity occupies the 4th ranking place, and among the organs of the reproductive system – the 2nd place – 13.3 %, yielding to breast cancer (47.8 %). These figures reflect the lack of implemented programs aimed at reducing the incidence of cervical cancer.
MATHEMATICAL MODELING OF DIFFUSION BOUNDARY PROBLEMS WITH PERIODIC BOUNDARY CONDITIONS USING MATLAB AND C++ FOR NUMERICAL AND ANALYTICAL SOLUTIONS
Authors: Lukaševičs Edmunds , Kangro Ilmārs
Published: October 2023

The article examines a second-order parabolic partial differential equation of a three-dimensional (3D) non-stationary boundary problem with constant diffusion coefficients and periodic boundary conditions in the x and y directions. The method for reducing the (3D) non-stationary boundary problem to the corresponding one-dimensional (1D) non-stationary boundary problem using periodic boundary conditions in the x and y directions is discussed. The stationary (analytical) solution of the obtained (1D) stationary boundary problem is also obtained. The numerical solutions of the 1D boundary problem are obtained using the Matlab package "pdepe" and the C++ programming language. As a practical application of the developed mathematical model, the article discusses calculating the concentration of heavy metal Ca in a peat layer based on the obtained experimental data (measurements).
A clinico-histopathological study of skin appendageal tumours in a tertiary health care centre in western Odisha– A case series
Authors: Mishra Pragnya P. , Sahu Puspanjali , Panigrahi Sarita , Hota Smruti Ranjan , Kumari Priya , Panda Premanand
Published: October 2023

Skin appendageal tumours (SATs) are those neoplasms that arise from pilosebaceous, apocrine, or eccrine sweat glands. These are a diverse group of tumours with both benign and malignant counterparts. They can be single, multiple, or have a syndromic association with internal malignancies. Benign adnexal tumours are more common, while malignant adnexal tumours are rare, usually locally aggressive, and have the potential for nodal involvement and distant metastasis with a poor clinical outcome. Therefore, proper diagnosis of SATs is important for therapeutic and prognostic reasons.

This study aims to determine the clinico-histopathological correlation in cases of SATs in our hospital. It is a case series conducted over a one-and-a-half year period from January 2021 to July 2022. All clinically suspected cases of SATs were examined, biopsied, and subjected to histopathological examination. Histopathologically confirmed cases of SATs were finally analysed. Among twenty-four thousand two hundred twenty-four new patients attending OPD, 30 suspected cases of ATs underwent histopathological examination. Histopathology was confirmatory in only 12 cases (40%). 10 cases were benign, and two were malignant. Out of 10 benign cases, hidradenoma was noted in 3 (25%), trichoepithelioma in 2 (16%), proliferating pilar tumour, apocrine hidrocystoma, steatocystoma multiplex, hidradenoma papilliferum, and pilomatrixoma were seen in one each. Females (75%) outnumbered males (25%) in our study population.

: SATs are infrequent and are not frequently observed in the field of surgical pathology. Histopathology is the gold standard for diagnosis.
Multi-Modal Medical Image Matching Based on Multi-Task Learning and Semantic-Enhanced Cross-Modal Retrieval
Authors: Zhang Yilin
Published: October 2023

With the continuous advancement of medical imaging technology, a vast amount of multi-modal medical image data has been extensively utilized for disease diagnosis, treatment, and research. Effective management and utilization of these data becomes a pivotal challenge, particularly when undertaking image matching and retrieval. Although numerous methods for medical image matching and retrieval exist, they primarily rely on traditional image processing techniques, often limited to manual feature extraction and singular modality handling. To address these limitations, this study introduces an algorithm for medical image matching grounded in multi-task learning, further investigating a semantic-enhanced technique for cross-modal medical image retrieval. By deeply exploring complementary semantic information between different modality medical images, these methods offer novel perspectives and tools for the domain of medical image matching and retrieval.
Comparison of Dexmedetomidine and Nalbuphine on Intubating Conditions and Hemodynamic Responses During Awake Fiberoptic Intubation: A Randomized Study
Authors: Chaudhary Sujata , Ananth R C , Bharti Swati , Salhotra Rashmi , Kumar Mahendra
Published: October 2023

Background: The pre-requisites to a successful awake fiberoptic intubation (AFOI) include adequate psychological and pharmacological preparation of the patient. This study aims to compare two pharmacological agents, dexmedetomidine and nalbuphine, in addition to nebulization and airway topicalization, for intubating conditions during AFOI.
Methods: Sixty consenting patients belonging to ASA I/II, MPC I/II, age-group of 18-60 years weighing between 40-70 kgs requiring general anaesthesia with endotracheal intubation were randomly allocated to one of the two groups. Patients received dexmedetomidine 1µg/kg i.v. (group D) or nalbuphine 0.2 mg/kg i.v. (group N) over 10 min before intubation. Fiberoptic intubation was attempted. Intubating conditions were assessed in terms of sedation score, cough score and post-intubation score. Hemodynamic responses, lignocaine and propofol requirement were also recorded. Repeated measure ANOVA, Tukey’s test, unpaired t test, Chi‑square test or Fisher’s exact test were used for data analysis. A P < 0.05 was considered significant.
Results: Sedation score (P = 1.000), cough score (P = 0.165) and post‑intubation score (P = 0.157) were comparable among the two groups. Hemodynamic responses, propofol and lignocaine requirements were also comparable.
Conclusion: Both intravenous dexmedetomidine and nalbuphine provide good intubating condition with minimal adverse effects on haemodynamic profile during awake fibreoptic intubation.
Ease of Internal Jugular Venous Cannulation by Anterior V/S Posterior Approach: A Randomized Interventional Study
Authors: Mudigoudra Sunilgouda , Saiyed Anjum , Bano Parbeen , Garg Arun , Meena Reema
Published: October 2023

Background: Percutaneous cervical central venous cannulation is now common practice during Perioperative care in major surgical procedures, critically ill patients in intensive care units for long term hyperalimentation and for rapid restoration of blood volume in cases of acute blood loss. Proper route of insertion is essential for its success. The objective of this study is to compare procedural parameters and complications associated with anterior and posterior approaches for Internal Jugular Venous cannulation.
Methods: Our study was conducted as a prospective randomized interventional trail in 60 patients undergoing scheduled cardiac surgeries requiring Right internal jugular venous cannulation in a tertiary level hospital after obtaining clearance from ethics committee, patients were randomly allocated into two groups either Anterior approach (Group A; n=30) or Posterior Approach (Group B; n=30). Number of attempts, time for identification of IJV, duration of cannulation, ease of insertion, complications were compared in both the groups.
Results: The number of attempts (p value 0.036), mean time taken for vein identification (p value 0.0003), catheterization time (p value <0.001), incidence of arterial puncture and hematoma are less with posterior approach, ease of threading is comparable among both the group. There were no statistically significant intergroup differences with respect to the Age, Sex, ASA grade.
Conclusion: The posterior approach is better than anterior approach for Internal Jugular Vein Cannulation, as it improves the success rate, permits easy threading of catheter, reduces access time and duration of cannulation, complications like arterial puncture, hematoma, pneumothorax are lesser in posterior approach.
Midwives' Attitudes to Painless Delivery: An Observational Study
Authors: Vosoughian Maryam , Dabir Shideh , Dahi Mastaneh , Moshari Mohammadreza , Tabashi Soudeh , Madadi Firoozeh
Published: October 2023

Background: Parturient health is a priority worldwide. In this regard, the promotion of natural childbirth has always been considered by health policy makers. However, the most important cause of parturient tendency to caesarean section is fear of labour pain and lack of information about surgery complications, leading to inappropriate rate of caesarean. Midwives, attending in prenatal visits and labour, may have a key role in encouraging pregnant patients through labour analgesia. In this study we evaluate midwives’ attitude through necessity of labour analgesia and their understanding of neuraxial analgesia for labour pain.
Methods: One hundred and five midwives working educational hospitals, participated in this observational study. All participants were asked to fill questionnaires. Each questionnaire consists of 15 questions, each answer had 1 to 3 points. Total score of 15 to 25 was considered as poor, score 26 to 35 as intermediate and 35 to 45 as good attitude.
Results: Forty-nine percent of midwives had experience with labour analgesia. Forty-one percent participated in relevant educational workshops. About 40% presumed these techniques would result in immobility, while 66% assumed it will lengthen the procedure. 63% believed labour analgesia will increase mother’s satisfaction. Overall, 73% of them agreed with regional analgesia. In regards to attitude score, 22% were scored poor, 65% intermediate and 13% good.
Conclusion: Midwives’ attitude was estimated low. Participating in workshops improved their attitude, yet the difference was not significant. Attitude of those who participated in labour analgesia was significantly better than others.
Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care
Authors: Hejazi Mohammad Esmaeil , Takaldani Ali Hossein Samadi , Ranjbar Abdolmohammad , Negaresh Mohammad
Published: October 2023

Background: Sepsis is a serious condition that can be fatal and has become more common in recent times. The impact of diastolic dysfunction on the early mortality rate of septic patients has not been extensively researched. This study aimed to assess the accuracy of serum procalcitonin (PCT) levels and diastolic dysfunction in predicting the mortality rate of patients diagnosed with sepsis and admitted to the intensive care unit.
Methods: In this cross-sectional study, 40 sepsis patients admitted to the ICU were examined. Their characteristics were meticulously recorded using the APACHE II and SOFA score questionnaires, and only those who met the criteria underwent echocardiography. In order to evaluate the serum levels of PCT, it was required to take 40 ml of venous blood samples from the patients on the first and fifth days of admission.  
Results: Out of 40 patients, the average age was 63±17 years. Of these patients, 23 (57.5%) were discharged, while 17 (42.5%) unfortunately passed away. Results showed a notable correlation between diastolic dysfunction, CRP, SOFA score on days 1 and 2, APACHE II score, and PCT on day 5 (P˂0.05). However, when analyzed using logistic regression, only PCT on day 5 showed a significant association with mortality.
Conclusion: Based on our research, we found that PCT is an essential indicator in predicting the mortality rate of sepsis patients. While there was no significant correlation between diastolic dysfunction and mortality, it should still be considered a critical factor in determining the mortality rate.