bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurological complications encountered in imaging studies in association with COVID-19 – a single center analysis
Authors:   Department of Radiology, University of Heath Sciences, Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey, Erok Berrin , Atca Ali Önder ,   Department of Radiology, Altınbas University School of Medicine Bahcelievler Medical Park Hospital, İstanbul, Turkey, Önder Hakan ,   Department of Radiology, University of Heath Sciences, Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey
Published: April 2022

Introduction and aim. COVID-19 is a viral infectious disease, which was first reported in patients with unusual pneumonia in December 2019. However, as the pandemic progressed, extrapulmonary manifestations including various neurologic complications have been started to be increasingly reported. In this retrospective study, we tried to search the neurological complications seen in our patients with positive rRT-PCR test for COVID-19 and examine the underlying associated risk factors. Material and methods. We have retrospectively analyzed the neuroimaging studies performed in our patients with positive rRT-PCR test for COVID-19 between April, 2020 and August, 2021. Both computed tomography (CT) scans and magnetic resonance imagings (MRI) of brain, head & neck region and the spine were retrospectively evaluated for the presence of any complications in patients with positive rRT-PCR test for COVID-19. Results. There were 147 patients having neuroradiological imaging studies performed for various neurological symptoms. Among these patients we detected 10 acute neurologicalcomplications.The most common was acute ischemic stroke in 5 patients and intracranial hemorrhage in 3 patients, two of which were intraventricular hemorrhage. The other complications included a preasumed cytotoxic lesion of corpus callosum in a 18 year old girl and lumbar spondylodiscitis complicated with psoas abcess in a 47 year-old man. Conclusion. In COVID-19 patients severe neurological complications can occur even as a presenting manifestation. Early cytotoxic endothelial injury can be the underlying cause in these patients and should be further studied in larger series in terms of what the susceptibility factors in these patients.
Paired box 8 in organogenesis and oncogenesis – a review
Authors:   English Division Science Club, Medical College of The University of Rzeszów, University of Rzeszów, Poland, Szpunar Magdalena
Published: April 2022

Introduction and aim. Paired box 8 (PAX-8) is a specific transcription factor known as a protein product gene that plays an essential role in organogenesis and oncogenesis. The aim of this paper was to discuss structure and function of PAX-8. The aim of this study is to determine the utility of PAX-8 in cytology effusions with metastatic tumor. Material and methods. This article is a review done in regards to discuss the role knowledge on PAX-8 especially in oncogenesis and organogenesis. Analysis of the literature. Current information about PAX-8 is presented. Conclusion. The PAX family of genes plays an important role in the formation of tissues and organs during embryonic development and in maintaining the proper functioning of certain cells after birth.
Clinical profile and management of patients with pediatric inflammatory multisystem syndrome – temporally associated with SARS-CoV-2 – single-center experience
Authors:   Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland, Opalińska-Zielonka Paulina ,   Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland, Wiącek Katarzyna ,   Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland,   Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland, Marczak Paweł ,   Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland,   Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland, Piasecka Krystyna ,   Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland,   Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland, Korczowski Bartosz ,   Department of Pediatrics Regional Hospital No.2 in Rzeszow, Rzeszow, Poland,   Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Published: April 2022

Introduction and aim. Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) is a new condition that has emerged in children during the COVID-19 pandemic. Many clinical signs and symptoms resemble those found in Kawasaki disease (KD). Material and methods. The following data were considered: clinical presentation, comorbidities, laboratory findings, abnormalities in additional tests, exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the child and his family members, applied treatment and return to full health. Results. In the presented study nineteen children were analyzed. Fever was a universal finding in our group and it’s mean duration was 7 days (range 5-9). Other common symptoms included abdominal pain and severe weakness (in 89.5%), rash and conjunctivitis (in 84.2%), vomiting (in 73.7%) and mucous membrane involvement (in 63.2%). In nearly half of cases, echocardiography revealed fluid in the pericardial sac and left ventricular systolic dysfunction (in 52.6% and 47.4% respectively). 21.1% of patients had coronary artery abnormalities. 26,3% of the children required treatment with dopamine and/or milrinone. In 15.7% ICU admissions and assisted ventilation was necessary. No deaths were recorded. Conclusion. One should bear in mind that PIMS-TS can mimic KD, appendicitis and meningitis, which may pose a diagnostic challenge.
Arterial stiffness can predict cardiorespiratory fitness in type 2 diabetic patients?
Authors:   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil, Monteiro Clara Italiano , Simões Rodrigo Polaquini ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil,   Physiotherapy Department, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil, Heubel Alessandro Domingues ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil, Silva Claudio Donisete da ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil, Ricci Paula Angélica ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil, Petronilho Ariane ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil, Borghi-Silva Audrey ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil, Mendes Renata Gonçalves ,   Physiotherapy Department, Federal University of Sao Carlos, São Carlos, São Paulo, Brazil
Published: April 2022

Introduction and aim. Arterial stiffness (AS) has been associated with reduced cardiorespiratory fitness (CRF). The aim of this study was to verify if there is a relationship between augmentations index (AIx), as an index for AS assessment, and CRF in individuals with type 2 Diabetes Mellitus (T2DM). Material and methods. Observational cross-sectional study including 32 individuals diagnosed with T2DM who performed two evaluations: 1. Arterial stiffness assessment using SphygmoCor and 2. CRF throughout a cardiopulmonary exercise test on a treadmill ergometer. Oxycon Mobile® device was used to obtain oxygen uptake consumption at peak (V˙ O2peak); oxygen uptake efficiency slope (OUES) determined by linear regression in reason of the logarithmic transformation of the ventilation and V˙ O2 obtained every minute of exercise test. Statistical analysis comprised Pearson’s Correlation and linear regression analysis performed in SigmaPlot. Results. There was a significant correlation between AS and CRF: AIx and OUES; AIx@75 and; OUES. In linear regression, AIx was determinant for V˙ O2peak and OUES – AIx and; AIx@75 and V˙ O2peak. Conclusion. AS was associated with CRF in individuals with T2DM. These results contribute to the body of evidence linking arterial functional properties to CRF and suggests greater attention for this important index.
The incidence and pattern of non-odontogenic orofacial pain conditions at a tertiary hospital in Tanzania
Authors:   Department of Oral and Maxillofacial Surgery, Kenyatta National Hospital, Nairobi, Kenya, Hirani Vanisha Aroon , Owibingire Sira Stanslaus ,   Department of Oral and Maxillofacial Surgery, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Moshy Jeremiah Robert ,   Department of Oral and Maxillofacial Surgery, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Sohal Karpal Singh ,   Department of Oral and Maxillofacial Surgery, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
Published: April 2022

Introduction and aim. Non-odontogenic orofacial pain (NOFP) is a result of pathology, or injury to the structures in the orofacial region including the muscles, temporomandibular joint, neurovascular structures, and glands. This multi-diverse aetiopathogenesis poses a challenge in the diagnosis and management of NOPF. To determine the incidence and trend of various non-odontogenic orofacial pain conditions at a tertiary hospital in Tanzania. Material and methods. This cross-sectional study was conducted at the Muhimbili National Hospital (MNH) for 6 months. The information gathered included socio-demographic characteristics of participants, characteristics of pain, and cause of pain. Pain intensity was assessed using the Visual Analogue Scale (VAS). Results. The incidence of NOFP was 3.3%. The male to female ratio was 1.7:1 and the mean age of patients was 44.2 ± 17.4 years. The mean intensity of the pain using the VAS was 47.27 ± 5.66. Most (36.7%) patients experienced sharp pain. The common causes of NOFP were trauma (43.3%) and malignant lesions (38.3%). A statistically significant association between the age and sex of the patients and the causes of non-odontogenic pain was observed (p < 0.05). Conclusion. The incidence of non-odontogenic orofacial pain is low. Trauma and malignant conditions were the leading causes of NOFP.
Management of Date Palm Pests: Lack of Commercial Input
Authors: Ansari Minshad , Harding Sarah
Published: April 2022

According to Statista, the global date market was valued at about $13.4 billion in 2019 and is forecast to reach $16.25 billion by 2025. However, this valuable crop is threatened by numerous pests. In fact, the date palm is associated with 132 species of insect and mite
pests, which feed on the leaves, roots, trunk, and fruits on the palm, as well as stored dates. The most economically important pests include the red palm weevil, (Rhynchophorus ferrugineus), old world date mite (Oligonychus afrasiaticus), lesser date moth (Batrachedra amydraula),
Dubas date bug (Ommatissus lybicus), green pit scale (Palmaspis phoenicis), carob moth (Ectomyelois ceratoniae), date palm longhorn beetle (Jebusaea hammerschmidti) and almond moth (Cadra castellan). It has been estimated that effective curative approaches
for red palm weevil infestations alone could result in savings as high as $104 million. Several research groups are working to find effective solutions to control these pests, but as yet no commercial biocontrol products are registered or available for curative control of the palm beetle
and larvae. Therefore, a more robust Integrated Pest Management(IPM) system is needed to reduce the pest damage. Commercial formulations include root treatments, insecticide-based capsules that are injected into the trunk, or foliage/fruit sprays. However, chemical insecticides should not
be the only solution to the management of date palm pests, especially those concealed inside the trunk or beneath palm tissues, making them difficult to target. This is primarily because chemical insecticides frequently just kill the target pest's natural enemies, while the pests themselves
remain protected within the date palm. Several approaches are used but it has also been shown that resistance against a range of commonly used chemical insecticides (profenophos, imidacloprid, chlorpyrifos, cypermethrin, deltamethrin, spinosad, lambda-cyhalothrin, phosphine) develops after
extensive use. Resistance ratios as high as 79-fold have been reported, compared with susceptible control pests. Researchers have reported significantly improved populations of natural enemies of target pests in date palm plantations when chemical insecticide use is reduced. Around 90 species
of beneficial predators and parasitoids have so far been reported, suggesting that biological control with microbials could be incorporated into a synchronised IPM programme.
Prenatal Ultrasound Diagnostics of Autosomal Recessive Polycystic Kidney Disease in Fetus: Clinical Case
Authors: Normuradova Nodira M. , Pardaev Mirtalim А.
Published: April 2022

Background. Autosomal recessive polycystic kidney disease is a rare congenital anomaly with poor prognosis. It characterized by the development of cysts in kidneys parenchyma, secondary dilatation, and hyperplasia of normally formed collecting tube in kidneys.

Clinical case description. Autosomal recessive polycystic kidney disease was diagnosed in the fetus via ultrasound in the third trimester of pregnancy, signs of “large hyperechogenic kidneys” were revealed. The fetal kidneys were significantly enlarged, the parenchyma was thickened, and there was no cortico-medullary differentiation. The renal pelvises and bladder were identified. Amniotic fluid volume was normal. The ultrasound diagnosis was confirmed with magnetic resonance imaging. Female child born at full term, weight — 4500 grams, she was discharged home in satisfactory condition. At the age of 7 months, child physical development corresponds to her age. Ultrasound examination shows the persistence of pronounced increase in the size of kidneys, parenchyma thickening and no cortico-medullary differentiation. The renal pelvises and bladder are not dilatated. Urine analysis results: epithelia in large quantities, single leukocytes and isomorphic erythrocytes, as well as protein of 0.066 g/l. Blood creatinine and blood urea were within normal ranges.

Conclusion. Amniotic fluid volume and presence of urine in the bladder are the most important characteristics of the kidney functioning in case of antenatal ultrasound signs of autosomal recessive polycystic kidney disease. The absence of amniotic fluid at visualization of “large hyperechogenic kidneys” is considered as poor prognostic feature. MRI is crucial to clarify the diagnosis of autosomal recessive polycystic kidney disease and allows adequately estimate the amniotic fluid volume in the third trimester of pregnancy.
Yoga com histórias para crianças com transtorno do espectro autista: regulação emocional mediada pela internet
Authors: Darwich Rosângela Araújo , Costa Yasmin Santos Klautau
Published: April 2022

Resumo Este estudo de caso mediado pela internet objetivou avaliar possíveis relações entre contação de histórias associada a exercícios de yoga e autorregulação de crianças com transtorno do espectro autista. Para tanto, pais e cuidadores foram instruídos a utilizar vídeos de contação de histórias, vídeos com demonstração de rotinas de exercícios de yoga e formulários de avaliação, totalizando três encontros. Relações entre controle por contingências e governo por regras foram investigadas. Verificamos resultados positivos nos dois casos estudados, um deles mediado pelos pais da criança e outro pela acompanhante terapêutica. Em conclusão, o envolvimento de pessoas de referência no treino de autorregulação demonstrou gerar efeitos positivos no comportamento das crianças e nas relações interpessoais estabelecidas. Estudos futuros poderão se valer do delineamento testado e do material interventivo para alcançar um maior número de crianças com desenvolvimento atípico e típico.
Fishes of the Mitú Region: middle basin of the río Vaupés, Colombian Amazon
Authors: Bogotá-Gregory Juan D , Lima Flávio C. T. , Donascimiento Carlos , Acosta-Santos Astrid , Villa-Navarro Francisco A. , Usma-Oviedo José S. , Ortega-Lara Armando , Castro-Pulido William , Córdoba Edwin Agudelo
Published: April 2022

Abstract: The Amazon River basin hosts the most diverse freshwater ichthyofauna in the world, and yet huge areas of the basin remain unexplored. This is the case for the upper tributaries of the rio Negro, especially those draining the Colombian territory. Here we present a list of 224 species derived from the examination of specimens collected in the Mitú region (Vaupés Department, Colombia), the middle basin of the río Vaupés. Of the species identified in our study, 10 species are recorded from Colombia for the first time, and 26 species are newly recorded from the Colombian Amazon. The number of species we present here comprise almost one-third of the known species diversity of the Colombian Amazon and nearly a tenth of the total number of those known across the entirety of the Amazon basin. The most diverse orders were Characiformes (120 species) and Siluriformes (65 species), and the remaining six orders comprised less than 20% of total species. The study area comprised blackwater systems, which are considered to be nutrient-poor environments. We discuss some ecological aspects that might explain how this highly diverse ichthyofauna originates and is maintain in less productive systems. The list presented here adds an important number of new records and complements the information derived from previous studies, carried out thus far with regards to the fish fauna of the Colombian Amazon.
A dinâmica da informalidade no Brasil e na Argentina (2012-2019) e a vulnerabilidade da classe trabalhadora
Authors: Souza Danyelle Mestre de , Trovão Cassiano José Bezerra Marques
Published: April 2022

Resumo O objetivo do presente estudo foi identificar o comportamento da informalidade no Brasil e na Argentina, no período de 2012 a 2019. A definição conceitual de informalidade tem como base a legislação e as relações trabalhistas. Fundamentado nas informações das pesquisas domiciliares oficiais, explorou-se o comportamento da informalidade segundo os distintos setores de atividade econômica e a classificação dos trabalhadores por faixas de rendimentos. O período em questão foi caracterizado por transformações que ampliaram a flexibilização das relações de trabalho, em um processo de reconfiguração do mercado de trabalho impulsionado por reformas trabalhistas que, em teoria, proporcionariam uma redução do peso do emprego informal na estrutura ocupacional, à medida que essa flexibilização avançasse. Os resultados não sugerem mudanças significativas no comportamento da informalidade, e corroboram que esse fenômeno continua afetando negativamente, com mais intensidade, os trabalhadores que mais necessitam de proteção social e garantia de direitos. Desse modo, as medidas de flexibilização das relações de trabalho, ao menos considerando o período em análise, não produziram os resultados prometidos. Destaca-se, ainda, uma relativa convergência nos resultados encontrados para os dois países.
Simbolização e análise sociológica: fronteiras sociais, classificações e mobilidade a partir do longa-metragem Parasita
Authors: Nery Salete
Published: April 2022

Resumo Simbolizações são expressivas e orientadoras de condutas. A partir desta afirmação, buscamos analisar o longa-metragem Parasita, produção sul-coreana de 2019 e vencedora de diferentes prêmios internacionais, a partir do tema das fronteiras sociais, analisado mediante sua relação com duas categorias sociológicas fundamentais: classificação e mobilidade social. Buscamos compreender a aparente inflexibilidade das barreiras sociais e o modo como a estigmatização pela distinção entre cheiros corpóreos atribuídos a partir do recorte de pertencimento socioeconômico é acionado como recurso, complementando o debate sobre fronteiras sociais. Tomamos por referência a concepção de que as simbolizações têm seus significados constituídos na totalidade forma-conteúdo. Deste modo, concluímos o debate com a retomada do tema sobre as fronteiras sociais na observância da estratégia de seu diretor e roteirista, Bong Joon-ho, de ter sua obra não facilmente classificável em termos de um gênero específico.
Metamorfoses da imagem nas ciências sociais: três experiências com o filme etnográfico
Authors: Ferraz Ana Lúcia
Published: April 2022

Resumo Retomo aqui três experiências etnográficas realizadas em diferentes contextos, com o objetivo de pensar três diferentes regimes de imagem que se configuram quando as formas sociais exercem suas influências sobre as formas estéticas elaboradas no campo do filme etnográfico. No primeiro caso, uma pesquisa sobre o trabalho e o contexto da desindustrialização produz um filme etnográfico sobre 2.800 demissões; no segundo, a investigação dos modos de vida das classes trabalhadoras precárias culmina em uma cartografia de suas redes de relações; no terceiro, a etnografia da luta pela terra entre os povos Guarani revela outros sujeitos de agência política. Em todos estes processos, apreender os pontos de vista dos sujeitos estudados configura a possibilidade da compreensão antropológica.
Between visibility and listening: access of the LGBTI+ population to primary healthcare
Authors: Miskolci Richard , Pereira Pedro Paulo Gomes
Published: April 2022

Abstract This article aims to identify and analyze how health professionals working in primary care in the city of São Paulo undertand LGBTI+ people access to health. The research covered the six administrative regions of the city and this paper analyses in depth interviews with specialists of the administrative regions, and also with managers, physicians, nurses and nursing technicians/assistants in Basic Health Clinics trying to understand how they see the access of this segment of people into primary care. The access of LGBTI+ people to primary care tends to prioritize those visually recognizable and whose health demands can be understood in the frame of health centered on illness. This keeps many segments and health demands without attention. The results of the investigation point toward the need of switching the visual frame for a listening strategy to promote access of LGBTI+ people to integral health.
A sociologia da ciência e da tecnologia no Brasil: uma análise a partir da produção em periódicos A1 entre 2010 e 2018
Authors: David Marília Luz , Premebida Adriano , Fleury Lorena Cândido , Almeida Jalcione
Published: April 2022

Resumo Este trabalho analisa a produção em sociologia da ciência e da tecnologia publicada no Brasil entre 2010 e 2018 em periódicos nacionais Qualis A1 em sociologia. Foram examinados dados sobre o volume, tipo e distribuição das publicações, além das temáticas, objetos empíricos e conceitos mais frequentes. Analisou-se ainda o conteúdo das cinco temáticas a concentrarem o maior número de publicações. Com isso, espera-se i. esboçar um panorama sobre o perfil dos artigos; ii. identificar como estão distribuídos entre as revistas e instituições de pesquisa; iii. examinar tendências em relação às temáticas; e iv. traçar paralelos com a sociologia brasileira. Concluímos que este é um campo em expansão, cuja produção concentra-se em certas temáticas, objetos empíricos, revistas e instituições. Questionamos ainda por que temáticas importantes para os estudos sociais das ciências e das tecnologias (ESCT) encontram dificuldade em acessar periódicos desse estrato e quais questões em sociologia da ciência e da tecnologia (SCT) poderiam ser mais bem exploradas em pesquisas futuras.
Excesso de mortalidade segundo grupo de causas no primeiro ano de pandemia por Covid-19 no Brasil
Authors: Guimarães Raphael Mendonça , Oliveira Mariana Passos Ribeiro Pinto Basílio de , Dutra Viviane Gomes Parreira
Published: April 2022

O estudo estimou o excesso de mortalidade segundo causa de óbito no Brasil e estados em 2020. Estimamos as razões de mortalidade padronizada considerando os óbitos esperados pela tendência estimada para os 5 anos anteriores. Observamos um excesso de 19% nos óbitos em 2020 (SMR= 1,19; IC= 1,18- 1,20). Há diferenças por grupos de causa, destacando as doenças infeciosas, transtornos mentais, condições crônicas cardiovasculares/metabólicas e causas externas, além de causas mal definidas. Há enorme heterogeneidade entre os estados brasileiros. O excesso de óbitos é resultado tanto da Covid-19 quanto da resposta social e gestão do sistema de saúde.
Look before you LEEP: patient reported pain with IV sedation vs local analgesia
Authors: Frahm Allison J. , Hardy-Fairbanks Abbey J. , Stockdale Colleen K.
Published: April 2022

Objective: Examine the effectiveness of IV sedation in addition local analgesia compared to local analgesia alone for LEEP pain management. Methods: This quality improvement project surveyed 89 patients who underwent a LEEP procedure: 26 in the local only group and 63 in the IV + local group. Patients completed a visual analog scale and pain survey immediately following their LEEP. Results: The local analgesia + IV sedation group reported a lower average pain score compared to the local analgesia only group (2.4 ± 2.2 v 3.6 ± 2.7). However, this was not statistically significant, p 0.47. Patients found it was helpful to know what to expect prior to the LEEP and utilized various means of pain relief in addition to the primary treatments assessed. Conclusions: There is a need for high quality trials to determine best practices of pain management.
Efecto del ambiente y de caracteres morfológicos en variables bióticas y reproductivas de Pinguicula moranensis var. neovolcanica Zamudio (Lentibulariaceae) en Tlaxcala, México
Authors: Pérez-Alva Braulio Ricardo , García-de Jesús Sandra , Galindo-Flores Gema Lilia , Valencia-Quintana Rafael , Pérez-Flores Guillermo Alejandro
Published: April 2022

Antecedentes: La distribución geográfica de Pinguicula moranensis var. neovolcanica está restringida a la Faja Neovolcánica Transmexicana. En Tlaxcala, esta especie ha desaparecido en la mayoría de los sitios donde se había registrado. Es necesario entender la relación entre las características ambientales, morfológicas y reproductivas de las poblaciones que aún prevalecen.
Preguntas y / o Hipótesis: ¿Cuál es el efecto del ambiente y de los caracteres morfológicos sobre las variables bióticas y caracteres reproductivos de P. moranensis en Tlaxcala?
Especies de estudio: Pinguicula moranensis var. neovolcanica Zamudio.
Sitio y fecha de estudio: Panotla y San José Teacalco, Tlaxcala, México. Febrero y julio de 2019.
Métodos: En dos sitios se registraron las variables abióticas (luz y humedad) así como las variables bióticas (densidad, presas y visitadores florales). Se midieron los caracteres morfológicos de las plantas (diámetro de roseta, longitud y número de pedúnculos y flores) y reproductivos (número total de semillas, semillas fértiles, semillas abortadas y viabilidad).
Resultados: Se encontraron efectos positivos de la humedad, número de pedúnculos y número de semillas fértiles sobre la abundancia de presas. La diversidad taxonómica de presas se relacionó con el número de semillas fértiles. La luz, la densidad de individuos y la viabilidad de semillas tuvieron efecto positivo en el número de semillas fértiles.
Conclusiones: Los resultados indican que las variables abióticas, bióticas, morfológicas y reproductivas interactúan para determinar la presencia de las poblaciones de P. moranensis en Tlaxcala. Además, este estudio enfatiza la importancia de conservar los hábitats en la Faja Volcánica Transmexicana.

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Diversidad y riqueza de plantas parásitas del estado de Morelos, México
Authors: Galvan-González Luis Gil , Cerros-Tlatilpa Rosa , Flores-Morales Alejandro , Caspeta-Mandujano Juan Manuel , Flores-Castorena Álvaro
Published: April 2022

Antecedentes: Las angiospermas parásitas obtienen agua y nutrientes de un hospedero. Éstas pueden ser holoparásitas si obtienen agua y fotosintatos, o hemiparásitas, si obtienen agua y minerales. Las hemiparásitas se dividen en parásitas obligadas, si dependen del hospedero durante todo su ciclo biológico; o en facultativas, si no requieren del hospedero para sobrevivir. Entre las obligadas están los muérdagos, que además pueden parasitar a otros muérdagos, siendo entonces plantas epiparásitas. Para México se consideran 14 familias, 41 géneros y 411 especies de plantas parásitas.
Preguntas: ¿Cuál es la diversidad de angiospermas parásitas en Morelos?
Especies de estudio: Angiospermas parásitas.
Sitio de estudio: Estado de Morelos, México.
Métodos: Se revisaron 650 ejemplares de nueve herbarios (ENCB, FCME, HUAP, HUMO, IEB, MEXU, RSA, UAMIZ y XAL) y de 15 colecciones digitales (ARIZ, ASU, CM, COLO, F, GH, IND, LL, MO, NMC, NY, RM, UCR, UTC y TEX). Se colectaron 178 especímenes en diecinueve municipios. Los nombres de cada taxón fueron validados en Tropicos, The Plant List y el International Plant Names Index.
Resultados: Se registraron 11 familias, 22 géneros y 60 especies de plantas parásitas en Morelos. Del total, 14 especies son holoparásitas, 19 son hemiparásitas facultativas y 27 son hemiparásitas obligadas. Se reportaron diez especies de muérdagos epiparásitos, con cinco registros nuevos de interacciones previamente no documentadas.
Conclusiones: Las plantas parásitas representan el 1.69 % de la riqueza de angiospermas en Morelos, 24 especies son endémicas de México. La mayor diversidad se encuentra en Áreas Naturales Protegidas.

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“None of it was especially easy”: improving COVID-19 vaccine equity for people with disabilities
Authors: Sebring Jennifer C. H. , Capurro Gabriela , Kelly Christine , Jardine Cynthia G. , Tustin Jordan , Driedger S. Michelle
Published: April 2022

Objectives

Our study aimed to (1) identify barriers to equitable access to COVID-19 vaccines for Canadians with disabilities and (2) present recommendations made by study participants to improve immunization programs in terms of inclusivity and equitable access.

Methods

We invited Manitobans living with disabilities to participate in online focus groups. Focus groups were conducted across multiple disability experiences, although one focus group was advertised explicitly as offering simultaneous American Sign Language interpretation to encourage people who are d/Deaf or hard of hearing to participate. Participants were asked about their perspectives on the management of COVID-19 public health measures and vaccination program rollout. Participants were also asked about barriers and facilitators of their vaccination experiences and if they had recommendations for improvement.

Results

The participants identified three areas where they encountered routine barriers in accessing the COVID-19 vaccines: (1) vaccine information and appointment booking, (2) physical access to vaccination clinics, and (3) vaccination experience. While participants identified specific recommendations to improve vaccine accessibility for people with disabilities, the single most crucial advice consistently identified was to involve people with disabilities in developing accessible immunization programs.

Conclusion

Meaningful engagement with people living with disabilities in immunization program planning would help ensure that people with disabilities, who already face significant challenges due to COVID-19, are offered the same protections as the rest of the population. These recommendations could be easily transferred to the administration of other large-scale immunization campaigns (e.g., influenza vaccines).
A rare case report of piloleiomyomas
Authors: Amar Uttamrao Surjushe , Anand Saraswat , Vaishali Atram , Neha Mundada
Published: April 2022

Leiomyoma is a rare benign tumor of smooth muscle. In the word leiomyomas, “Leio” means “smooth”, “myo” means ‘muscle’, and “oma” means ‘tumor’. It may arise from smooth muscles of the skin, uterus, bladder, urethra. Depending upon the origin of skin smooth muscles cutaneous leiomyomas are of three main types: 1. Piloleiomyoma or leiomyoma cutis or pilar leiomyoma derived from arrector pili muscle; 2. Genital leiomyoma or dartoic myoma is derived from smooth muscle of the scrotum, vulva, and areola of the nipple, and 3. Angioleiomyoma is derived from the media of blood vessels. We report one such rare case of multiple piloleiomyomas.
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Multifunctional Green Infrastructure in Shrinking Cities: How Does Urban Shrinkage Affect Green Space Planning?
Authors: Lewis Olivia , Sousa Sílvia , Pinho Paulo
Published: April 2022

Despite global urbanization, not all cities have increasing populations. While not homogenous, shrinking cities arguably have different opportunities and challenges for green space than growing cities. This article reports a structured content analysis to investigate how urban green space planning evolved in two case study cities: Buffalo (New York, US) and Porto (Portugal). These cities both underwent shrinkage and suburbanization but with very different green space planning histories. The concept of green infrastructure is used as a lens to analyze green space planning change, specifically focused on multifunctionality. The aim of investigating how objectives and priorities for planning green spaces change during a period of urban shrinkage, and particularly what functions these cities have assigned to green space, showed that, over time, green spaces were expected to produce more ecological functions in both cities, and, particularly in Buffalo, contribute to the economic and demographic outcomes of the city. Overall trends in green space planning appear to have played a role but we find shrinking cities may leverage green space to meet unique needs. These findings contribute to the literature by addressing how shrinkage affects not only vacant areas but also overall green space planning, as well as suggesting that general green space planning studies should consider demographic change as a relevant context factor.
Nectários extra-florais em barbatimão: comparação entre áreas de cerrado queimado e não-queimado.
Authors: De Morais Helena Castanheira
Published: April 2022

Apesar da ampla literatura sobre a variação temporal e espacial na eficiência de nectários extra-florais (nefs) como defesa contra insetos herbí­voros, informações sobre variações no número de nefs entre indiví­duos de uma espécie de planta ainda são escassas. Nesse trabalho comparamos o número de nefs, em folhas de Stryphnodendron adstringens (Mart.) Cov. (Fabaceae, Mimosoideae), entre áreas de cerrado queimado e não queimado. As coletas foram realizadas em uma parcela com queimadas bienais e em uma área adjacente protegida contra fogo na Reserva Ecológica do IBGE (DF, Brasil), em área de cerrado tí­pico. Foi coletada uma folha em final da expansão de cada indiví­duo (n=15) e foi contado o número de nefs na raquis e nos três raquí­olos basais do lado direito da folha. O número de nefs na raquis variou pouco e não diferiu entre as área, enquanto os raquí­olos apresentaram um maio número de nefs na área queimada (t= 3,75; p<0,01). Esse resultado pode estar relacionado com a perda de folhas devido ao fogo e, nesse caso, nefs podem estar funcionando como uma defesa induzida nesta planta.
Concordance between the tumor mutational status and circulating tumor DNA in patients with colorectal cancer
Authors: Polyanskaya E. M. , Fedyanin M. Yu. , Boyarskikh U. A. , Kechin A. A. , Moroz E. A. , Polyakov A. N. , Kudashkin N. E. , Podluzhniy D. V. , Khrapov E. A. , Oskorobin I. P. , Shamovskaya D. V. , Aliev V. A. , Mamedli Z. Z. , Tryakin A. A. , Filipenko M. L. , Tjulandin S. A.
Published: April 2022

Background. Circulating tumor DnA (ctDnA) may act as a potential biomarker for predicting disease progression in patients with colorectal cancer (CRC), which are radically cured or receiving chemotherapy.Objective: to evaluate the sensitivity of the investigated ctDnA detection assay and quantify the concordance of genomic alterations between ctDnA and matched primary tumor tissue of patients with CRC.Materials and methods. we included patients with histologically confirmed stage I–Iv CRC treated in n.n. Blokhin Cancer Research Center from 2016 to 2021. DnA was purified from tissue samples using QIAamp DnA formalin-fixed paraffin-embedded (ffPE) Tissue Kit (QIAgEn, germany). next-generation sequencing (ngS) technique was used to detect genetic mutations in primary tumor. ctDnA mutations were detected by droplet digital PCR.Results. The sensitivity of platform (assay) for detecting genetic alterations in tissue samples was 97.82 %; in ctDnA – 51.20 % for all stages and 64.5 % for stage Iv CRC. Across eight genes (KRAS, TP53, APC, PIK3CA, BRAF, FBXW7, MB21D2, and SMAD4) concordance between primary tumor and ctDnA was 69.4 % (95 % CI 62.2–76.0). Sensitivity for all stages is 51.2 % (95 % CI 45.8–56.6), for metastatic CRC 64.5 % (95 % CI 53.3–74.5). The concordance across all genes was 65.4 % (95 % CI 57.1–73.1) and 83.8 % (95 % CI 69.6–92.9) for stage I–III and stage Iv CRC, respectively. The concordance rate between ctDnA and primary tumor tissue for KRAS alterations across all stages and stage Iv CRC was 78.3 % (95 % CI 66.7–87.3) and 90.9 % (95 % CI 64.7–99.0), respectively. with increasing tumor stage (T), the number of matches raised across all genes with the highest number observed in nx category.Conclusion. The study indicates high concordance between tumor tissue and ctDnA, especially for KRAS and BRAF genes in patients with metastatic CRC, suggesting the clinical utility of ctDnA testing as a minimally invasive method and alternative to tissue biopsy.
“Watch and wait” strategy (active dynamic follow-up) in the management of rectal cancer patients with a complete clinical response
Authors: Dudaev Z. A. , Khudoerov Dzh. Kh. , Mamedli Z. Z. , Aliev V. A. , Gordeev S. S. , Myshlyakov V. S.
Published: April 2022

Background. Currently available chemoradiotherapy regimens for distal rectal cancer often ensure complete regression of the tumor and lymph node lesions. Therefore, patients with a complete clinical response can be managed with a “watch and wait” (ww) strategy.Objective: to evaluate 2-year overall and progression-free survival in patients with local and locally advanced rectal cancer with a complete clinical response who were managed with the ww strategy.Materials and methods. we performed retrospective analysis of treatment outcomes in patients with newly diagnosed, histologically verified, stage II–III, mrT1–2n1–2m0, T3–4n0–2m0 (within 0–10 cm of the anal verge), and mrT2n0m0 (within 0–5 cm of the anal verge) rectal cancer who had demonstrated complete clinical response to chemoradiotherapy. mandard tumor regression grade (TRg1–2) (assessed using magnetic resonance imaging of the pelvis) and palpatory/visual signs of residual tumor (assessed by digital examination and colonoscopy) were the main parameters evaluated. Overall and disease-free survival was analyzed using the Kaplan–meier method.Results. Twenty-seven patients with a complete clinical response were assigned to the ww group. mRI scans of the pelvis demonstrated that 5 patients (18.5 %) had TRg1, whereas 22 patients (81.5 %) had TRg2. T-downstaging after therapy was observed in 21 participants (77.7 %). n-downstaging was registered in all 14 patients (100 %) with regional lymph nodes affected. median follow-up time was 41 months (range: 25–114 months). Two individuals (7.4 %) developed progressive disease. Both of them had lengthy tumors as demonstrated by digital examination, colonoscopy, and magnetic resonance imaging; they immediately underwent radical surgery. The two-year overall and disease-free survival rates were 100 % and 92.6 %, respectively. Conclusion. The ww strategy with active dynamic follow-up is safe for the management of patients with local and locally advanced middle and lower rectal cancer, provided that inclusion/exclusion criteria are adhered to and patients are carefully followed-up in specialized centers.
Stereotactic body radiation therapy in patients with liver oligometastases from colorectal cancer: a systematic review
Authors: Moskalenko A. N. , Lyadov V. K. , Sagaydak I. V. , Chernykh M. V. , Britskaya N. N.
Published: April 2022

The purpose of the systematic review is to summarize the data regarding safety and efficacy of stereotactic body radiation therapy in patients with oligometastases of colorectal cancer to the liver.Published scientific articles on the topic were identified by searching the databases mEDLInE, Pubmed, EmBASE. The review includes publications reporting on the results of treatment of patients undergoing stereotactic radiation therapy for. The systematic review includes all retrospective and prospective studies found over the past 15 years with at least 10 patients with liver metastases of colorectal origin included and standardized methodology of radiation therapy. We included into the review 20 studies comprising 919 patients. Comparative analysis was complicated because of the absence of control groups in all of the studies. moreover, 16 studies were single-center with heterogeneous groups of patients and various regimens of stereotaxic radiation therapy. Despite this, the researchers achieved 60–100 % rates of one-year local control, 56–100 % one-year overall survival with median overall survival up to 45 months and the number of clinically significant complications less than 10 %.From our point of view, the results of published studies support the safety and efficacy of stereotactic radiation therapy in patients with colorectal cancer and oligometastatic liver disease. we consider stereotactic body radiation therapy to be one of the local control options in case of careful patient selection and the use of modern radiation therapy options. further randomized controlled trials are needed.
Gamification in the context of digital transformation of education
Authors: Shirokolobova Anastasia G.
Published: April 2022

The paper focuses on one of the urgent problems of modern education gamification in the context of digital transformation of education. The digital transformation of education has created not only the problem of changing the teaching system, but also has given great opportunities to teachers to use the synthesis of the best teaching traditions and introduction of digital technologies into the educational process, since digital technologies can change the form of teaching disciplines radically. A review of scientific literature on the issue under the study allowed us to conclude that gamification has been used in scientific publications mainly in three areas of knowledge: marketing, information management and education. The aim of the research is to develop a level-based gamification system for technical and humanitarian subjects, which can be the element of electronic courses on the LMS Moodle platform and allow to form and evaluate soft skills and increase the student motivation in the process of blended learning. The research methods were the analysis and generalization of methodological literature on the topic; observation methods (direct and indirect observation, questionnaire), experiment. The practical basis of the research was made up in the following subjects Foreign Language, Resistance of materials, Philosophy, Life Safety, History of Russia, Engineering Graphics. Electronic courses were developed for the implementation of blended learning in the educational process in the LMS Moodle platform at a technical university. The definition of the term gamification is considered. An experiment was conducted to develop an electronic course on the LMS Moodle platform with the introduction of gamification in the educational process. The author suggests a four-level gamification system integrated into e-courses, which allows to form and evaluate the formation of soft skills and increases motivation for learning.
Characteristics of a resilient leader of a humanitarian organization
Authors: Plyushcheva Olga A. , Makhnach Alexander V.
Published: April 2022

Under the influence of ecological, economic, political and other changes, organizations, employees and their leaders inevitably and regularly face impacts that are reflected in the experience of uncertainty about their future prospects. To resist these crises, rebuild and develop, organizations must form resilient leaders and employees. The development of resilient leaders increases the ability to positively influence the entire staff of the organization and becomes their strategic advantage in overcoming difficult periods. We are convinced that such development of resilient leadership should be selected specifically for each organizational environment, its features and tasks. In this regard, the purpose of our research was to study such characteristics of the leaders of the organization that employees define as resilience and whether the subjective perceptions of employees can contribute to the choice of methods to strengthen the resilience of the organization. The empirical study involved specialists of a non-profit organization performing professional duties of staff and volunteers (N = 106, men 7.5%, women 92.5%, average age 36.7). Content-analysis was used as a research method. The results showed that the study of the characteristics of the subjective perceptions of the organizations employees about the characteristics of the resilience of their leaders can form an idea of which areas of leadership strategies require changes, which are sufficiently resourceful and can be used to select support measures, which will contribute to the targeted and specific assistance required by the organization to strengthen its resilience and the resilience of its employees. Further research in this area will be useful for a deeper understanding of the phenomenon of professional resilience and can be applied for practical purposes to manage professional resilience to help organizations and professionals overcome crises, recover and continue their development.
Coefficient Diagram Method Based Decentralized Controller for Fractional Order TITO Systems
Authors: DENİZ Furkan Nur , GÜNAY Miray
Published: April 2022

Fractional calculus has gained increasing attention from researchers because of providing accurate modelling and flexible controller design in control applications. More research to design controllers for Fractional Order Two-Input Two-Output (FOTITO) systems, which inherently have certain difficulties, is needed when the studies about these control applications are considered. In this study, Coefficient Diagram Method (CDM) based decentralized controllers are designed for FOTITO systems. For this, integer order approximate models of FOTITO systems are obtained and decoupled into two subsystems by using simplified and inverted decoupling configurations. Obtained high-order approximate subsystem transfer functions are reduced by a model reduction method to facilitate CDM-based decentralized controller design. Then, CDM-based decentralized controllers are designed for each subsystem, which enables to obtain the controllers of the FOTITO system. Simulation results for two different FOTITO systems, one of which is a time delay fractional order system, are demonstrated that the proposed approach exhibits successful performance.