bluuebunny/crossref_metadata_2025 huggingface dataset:
Dendritic Cell-Derived IL-12 Promotes B Cell Induction of Th2 Differentiation: A Feedback Regulation of Th1 Development
Authors: Skok Jane , Poudrier Johanne , Gray David
Published: December 2022

B cells convert what are normally conditions for Th1 differentiation into an environment suitable for Th2 development. This capacity is dependent on CD40 as B cells from CD40−/− mice do not elicit Th2 differentiation. To elucidate the basis of this effect, we surveyed cytokine RNA made by naive B cells after activation with anti-Ig and anti-CD40. Resting B cells make TGF-β message only, however, 4 days after activation, RNA encoding IL-6, IL-10, and TNF-α was found. The expression of these messages was accelerated by 2 days in the presence of IL-12. The relevance of these observations to T cell differentiation was investigated: addition of OVA peptide to splenic cells from DO.11.10 transgenic mice causes most T cells to make IFN-γ. Coactivation of B cells in these cultures reduces the number of IFN-γ-producing T cells and increases the number synthesizing IL-4. Abs to IL-6 and IL-10 block the IL-4 enhancement. Dissection of the component APC demonstrated that interaction of B cells with IL-12-producing dendritic cells is crucial for B cell-mediated IL-4 enhancement: Thus, B cells preactivated in the presence of dendritic cells from IL-12−/− mice show little IL-4-inducing activity when used to activate T cells. This immune regulation is initiated by IL-12 and therefore represents a feedback loop to temper its own dominant effect (IFN-γ induction).
In Vivo Priming by DNA Injection Occurs Predominantly by Antigen Transfer
Authors: Corr Maripat , von Damm Amila , Lee Delphine J. , Tighe Helen
Published: December 2022

DNA vaccines can stimulate both humoral and cytolytic immune responses. Although bone marrow-derived elements present the expressed Ag, the mechanisms for acquiring immunogenic peptides have yet to be fully elucidated. APCs may become directly transfected by plasmid DNA or process extracellular proteins produced by other transfected cells. Using a transactivating plasmid system and bone marrow chimeras, we show that both mechanisms appear to be involved; however, the bulk of the immune response is dependent on expression of Ag by nonlymphoid tissues and transfer to APCs. These in vivo studies are the first to define the role of transfected nonlymphoid cells in generating Ag for presentation by bone marrow-derived APCs after needle injection with plasmid DNA.
Preferential Role for NF-κB/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo
Authors: Aronica Mark A. , Mora Ana L. , Mitchell Daphne B. , Finn Patricia W. , Johnson Joyce E. , Sheller James R. , Boothby Mark R.
Published: December 2022

T cell function is a critical determinant of immune responses as well as susceptibility to allergic diseases. Activated T cells can differentiate into effectors whose cytokine profile is limited to type 1 (IFN-γ-dominant) or type 2 (IL-4-, IL-5-dominant) patterns. To investigate mechanisms that connect extracellular stimuli with the regulation of effector T cell function, we have measured immune responses of transgenic mice whose NF-κB/Rel signaling pathway is inhibited in T cells. Surprisingly, these mice developed type 2 T cell-dependent responses (IgE and eosinophil recruitment) in a model of allergic pulmonary inflammation. In contrast, type 1 T cell responses were severely impaired, as evidenced by markedly diminished delayed-type hypersensitivity responses, IFN-γ production, and Ag-specific IgG2a levels. Taken together, these data indicate that inhibition of NF-κB can lead to preferential impairment of type 1 as compared with type 2 T cell-dependent responses.
On the Heat Stability of the Diphtheria Toxin
Authors: Ando K. , Nishimura H.
Published: December 2022

The property of heat sensitiveness is considered as a characteristic of bacterial exotoxins. In a previous paper (2), however, we have pointed out that a part of the scarlatinal toxin could stand boiling for thirty minutes. It seems rather curious that the scarlatinal toxin is an exception to this general rule. In order to analyse this general rule—heat sensitiveness of exotoxins—we examined carefully the heat stability of the diphtheria toxin as a typical exotoxin and found that a part of the diphtheria toxin also could stand boiling for thirty minutes.

Five portions of diphtheria toxin No. 166 (pH 8.5; m.l.d. = 1/300 cc.) heated to varying temperatures (60°, 70°, 80°, 90°, and 100°C.) for thirty minutes were tested for their m.r.d. on two guinea pigs and it was found that the ratio of m.r.d. of the heated toxins and that of unheated control was 50 (60°C.), 500 (70°C.), 2,000 (80°C.), 10,000 (90°C.) and 10,000 (100°C.) respectively.
The Reaction of Rheumatoid Factor and Complement with γ-Globulin Coated Latex
Authors: Bernhard Gerson C. , Cheng William , Talmage David W.
Published: December 2022

Summary and Conclusions

A modification of the rheumatoid latex fixation test which involves photometric measurements of the supernatant permitted plotting of agglutination curves and was used to characterize the “reactant” globulin. Both unaggregated electrophoretically obtained human γ-globulin and commercially prepared Cohn Fraction II were found to be suitable reactants. Heating Cohn Fraction II reduced the spontaneous precipitation of the coated latex. It was suggested that the heating process, in addition to slightly denaturing Cohn Fraction II, partially deaggregated it. Data were obtained which showed a relatively low and variable protein-binding capacity for latex, from 2.6 to 12.4 µg of γ-globulin nitrogen/mg of latex. The variation in protein adsorption was attributed to heterogeneity of the γ-globulin, since protein adsorbed to latex was firmly bound and did not exchange measurably with another protein added later. Despite the evidence that only a small fraction of the γ-globulin added in the test procedure was adsorbed to latex, excess γ-globulin did not inhibit the agglutination test. It was therefore postulated that a close apposition of γ-globulin molecules on the latex surface increased the strength of rheumatoid factor attachment, and that complement and rheumatoid factor attached to the same sites on the aggregated γ-globulin. Additional evidence given in favor of this concept included the fixation of complement by γ-globulin coated latex and the presence in fresh serum of a heat-labile inhibitor. On the other hand, data were also presented suggesting slight differences between the specificity of complement and rheumatoid factor for sites on aggregated γ-globulin.
New agglutinated Foraminifera from Early Eocene deposits of Mahallat region, Central Iran: implication on biostratigraphy and paleoecology
Authors: Babazadeh Seyed Ahmad
Published: January 2023

This paper describes the foraminiferal associations along with the presentation of three new agglutinated conical foraminiferal species to the construction of the biozonation framework in the Mahallat region of central Iran. The stratigraphic distribution of benthic foraminifers is used to characterize three assemblage zones that are in ascending order: rotaliids-valvulinids Assemblage Zone, alveolinids-coskinolinids Assemblage Zone, and nummulitids-discocyclinids Assemblage Zone. These associations are characterized by marker fossils and localized from the inner ramp to the proximal outer ramp depositional environments. Their biostratigraphic range is assigned to the middle Cuisian to early Lutetian. In addition, three new agglutinated conical foraminiferal species: Daviesiconus mahallatensis sp. nov., Barattolites arghadehensis sp. nov., and Coleiconus minimus sp. nov. are described and figured for the first time from the lower Eocene shallow-water limestone in the studied area. These new species have common characteristics such as eccentric conical test with a low number of comparably coiled chambers in the early stage and uniserial chambers in the adult stage, but they differ in size, the form of test, and radial subepidermal partitions (beams, intercalary beams, and rafters). They are associated with the index Alveolina fauna and their biostratigraphic range is assigned to middle–late Cuisian (Ypresian, Early Eocene). Keywords: biostratigraphy, Early Eocene, new taxa, Mahallat, Iran.
First record of plant macrofossil from the Boa Vista Formation, Takutu Basin, Roraima State, Brazil
Authors: Oliva Daisy Alves , Marques-de-Souza Juliane , Iannuzzi Roberto , Wankler Fábio Luiz
Published: January 2023

Clayey intraclasts containing leaves preserved as impressions and compressions were collected from the Takutu River channel in the State of Roraima, Brazil. In the present study, 23 leaf fragments are described (morphologically and anatomically) and their taxonomic identity is proposed. These fossiliferous intraclasts were suggested in previous studies as coming from the Boa Vista Formation (Upper Pleistocene–Holocene). With the aim of finding new evidence to support this correlation, X-ray diffractometry (XRD) and Laser induced-breakdown spectroscopy (LIBS) analysis were performed, comparing the fossiliferous sample with two outcrops from the Boa Vista Formation. The results evidenced the chemical and mineralogical similarity between the fossiliferous intraclasts and both outcrops, suggesting their correlation with the Boa Vista Formation. Taxonomically, the specimens were recognized as fossil representatives of Dilleniaceae Salisb., Byrsonima Rich. ex Kunth (Malpighiaceae), Zanthoxylum L. (Rutaceae), and other six morphotypes. These taxa represent typical elements of the savanna (lavrados) of Roraima. The anatomical-cutillary characters of the mummified leaves indicate the dominance of xeromorphic plants, similar to the predominant woody species in the “lavrado” today, thus suggesting the same climatic-environmental conditions. Keywords: fossil leaves, leaf architecture, cuticular anatomy, angiosperm, Cenozoic.
Challenges of objective structured clinical examination as a tool in medical assessment
Authors: Behera Priyamadhaba , Gopi Gokul , Siddaiah Archana , Sridhar Pooja R. , Patro Binod Kumar , Subba Sonu Hangma
Published: December 2022

Medical education is witnessing changes across the globe to produce more competent and responsive medical graduates to meet patients' growing needs. Medical educators are aspiring for more objective and relevant assessment methods for the evaluation of medical graduates. Objective structured clinical examination (OSCE) introduced in the year 1975 for clinical evaluation has gone through many changes over the past 45 years and matured over time. The article describes the challenges of OSCE as a tool in medical assessment from students' and organizers' perspectives. We have also suggested a feasible solution to address the challenges while conducting OSCE to assess medical students.
Health insurance coverage and out-of pocket expenditure
Authors: Singh Mitasha , Goyal Pooja , Narang Sangeeta , Singh Abhishek , Singal Mansi
Published: December 2022

Introduction:

Catastrophic health spending is one of the major factors pushing people into poverty. Reducing “out-of-pocket expenditure (OOPE)” on health through health insurance coverage is an effective approach. The objectives of this study are (1) to estimate health insurance coverage among rural and urban households (HHs) and (2) to determine the proportion of income spent on health as OOPE among the selected HHs.

Material and Methods:

A cross-sectional study was conducted in rural and urban parts of district Faridabad, Haryana. A sample of 374 were taken from rural and urban areas. The unit of the study was HHs in both the areas. The proportion of income spent on health care (both direct and indirect expenses included) as OOPE was taken as outcome variable.

Results:

Health insurance coverage was higher among urban HHs (58.0%) as compared to the rural (38.5%). The rural population was availing of private consultation, laboratory, and pharmacy services to a greater extent than the urban; hence, they were spending a substantial proportion of their income on health-care services. The majority of the HHs in the rural and urban areas spent up to 20% of their income on health care.

Conclusion:

Universal health coverage without health insurance is unlikely.
Knowledge, awareness, and risk prevention among hepatitis patients attending a tertiary care hospital in Delhi
Authors: Tiwari V. K. , Balsundaram P. , Raj T. P
Published: December 2022

Introduction:

People living with chronic viral hepatitis in India often lack awareness on risk factors and prevention. Moreover, due to fear of stigma and discrimination, they often delay appropriate and timely treatment, resulting in chronic treatment and impoverishment. The objective of this study is to assess knowledge, awareness, and prevention regarding risk factors among viral hepatitis-infected patients attending a super-specialty hospital in Delhi.

Material and Methods:

Data were collected from 389 patients using systematically random sampling using a pretested, structured interview schedule from patients attending Institute of Liver and Biliary Sciences, New Delhi.

Results:

Findings revealed that 90.7% of the respondents believed that hepatitis B virus/hepatitis C virus (HBV/HCV) can be transmitted through sexual contact with a person who is infected, 94.3% said that it can be transmitted by transfusion of infected blood, 90% reported that it can be spread from infected mother to child during child birth, 93.8% responded that it can be transmitted if a person uses a razor, pierced ear ring, needle, or syringe used by an infected person, 83% believed that HBV/HCV can cause cancer in 90% of the respondents in long run, and more than 35% believed that HBV/HCV is curable. Results also show that 7.2% of the respondents have been vaccinated for HBV infection in the past, 20.8% of the respondents have screened their families for hepatitis B infections, and 77.9% of the respondents have received antiviral medications.

Conclusion:

HBV/HCV-infected patients had less knowledge about various facts regarding disease and continue to experience emotional disturbances, stigma, and discrimination.
Lung schwannomas, an unusual entity
Authors: Walvir Nazia M. , Makhdoomi Rumana H. , Zargar Meesa , Aiman Aiffa , Maqsood Shadab
Published: December 2022

Schwannomas are benign slow-growing tumours arising from the Schwann cells of the nerve sheath. They may arise anywhere in the course of the nerves in the body. The clinical presentations are non-specific, and when present in rare locations such as lungs, the diagnosis becomes difficult. The present case series describes the clinical presentation and diagnosis of five cases of lung schwannoma. The diagnosis was mainly assisted by the immuno-histochemical examination comprising markers such as S-100, Calretinin, CD34, CD56, Desmin, and EMA. A definitive diagnosis of benign nerve tumours in such rare locations may help in better pre-operative assessment and surgery for complete recovery of the patients.
Years of life lost due to chronic obstructive pulmonary disease in Khuzestan province during 2011–2019
Authors: Azarbakhsh Habibollah , Abdipour Mahin , Moftakhar Leila
Published: December 2022

Introduction:

Chronic obstructive pulmonary disease (COPD) is one of the major causes of morbidity and mortality and a major public health problem all over the world. Therefore, this study aimed to investigate the years of life lost (YLLs) due to COPD between 2011 and 2019 in Khuzestan province, southern Iran.

Methods:

This cross-sectional study evaluated a total of 715 COPD-related deaths during 2011–2019 in Khuzestan, Southern Iran. Required information comprised of age, gender, and number of deaths were collected. First, crude and age-standardized mortality rates were calculated, and then the joinpoint regression was used to evaluate the trend of YLLs.

Results:

The highest number of deaths during the study period was observed in males (65%) and in the age group of over 70 years (52.6%). There was also a decreasing trend in crude and age age-standardized mortality rates in both genders. The total number of YLLs in both genders was 8650, 5747 in men and 2903 in women. Based on the results of joinpoint regression, the percentage of annual YII changes was −1.5% in men, −10.7% in women, and −6.6% in both genders.

Conclusion:

Estimating the trend of YLLs due to COPD can effectively help and lead the way of health policymakers and provide useful information to estimate the economic burden of the disease and assess health needs and priorities of a population.
Early experience of delamanid in extensively drug-resistant pulmonary tuberculosis
Authors: Marwah Vikas , Patil Prashant R. , Choudhary Robin , Malik Virender
Published: December 2022

Tuberculosis is a leading cause of death in our country. Multidrug-resistant tuberculosis increases the morbidity and mortality due to severe manifestations and difficult and prolonged medications. Newer antitubercular drugs like delamanid have been approved by WHO in management of these cases, but the real-world experience of this drug is lacking in our country. We present our early experience of use of delamanid in extensively drug-resistant pulmonary tuberculosis.
Clinical Pharmacist Interventions in Intensive Care Units during Hajj
Authors: Al Sulaiman Khalid , Aljuhani Ohoud , Al Harbi Mahasen , Thabit Abrar K. , F. Alharthi Abdullah , Aldardeer Namareq , Alenazi Ahmed O. , Alghamdi Badr , Alissa Dema , Almudaiheem Hajer , Alluwaymi Wafa , Almushaikah Sahar , Almustaneer Rana , Alshennawi Mohammed , Al-jedai Ahmed
Published: December 2022

Background:

Hajj pilgrimage is the largest mass gathering worldwide. The Saudi Ministry of Health (MOH) provides free medical services for all pilgrimages. In 2022, MOH incorporated clinical pharmacy services in intensive care units (ICUs) of the sacred rituals hospitals. In addition to their role in ICUs settings, they were involved in other activities related to emergency department admissions as well as conducting several educational services at the hospital level. This study aimed to describe the impact of clinical pharmacy services implementation during the Hajj season and to explore the clinical interventions delivered to ICU patients.

Materials and Methods:

A multicenter-retrospective, chart-review study including adult critically ill patients (>14 years old) admitted to ICUs of seven sacred rituals hospitals between June 30 and July 14, 2022. Patients were excluded if they were not admitted to the ICU or admitted to an area with no assigned clinical pharmacist. Clinical interventions were categorized based on a modified version of the American Society of Health-System Pharmacists (ASHP) categorization. The study was approved by MOH Central Institutional Review Board (IRB) on September 18, 2022 (Ref. 22-41 E).

Results:

Clinical pharmacists performed 269 interventions for 82 patients admitted to the ICUs of participating hospitals. Each patient had a median of three interventions (interquartile range 2–5). The most common intervention was the untreated indication (n = 93; 34.5%), followed by dose adjustment (n = 60; 22.3%) and improper drug selection (n = 42; 15.6%). The ICU teams ultimately accepted all interventions.

Conclusion:

Incorporating clinical pharmacy services into ICU settings during Hajj season optimized patient care. The variety of provided clinical interventions shows the impact of clinical pharmacists’ presence among multidisciplinary teams. Further studies are needed to explore the economic implication of clinical pharmacist services during Hajj.
Didáctica universitaria. Nuevos diseños innovadores para una educación a distancia.
Authors: Vicuña-Ureta Amilcar Máximo , Reyes Narváez Silvia Elizabet , Vilca Cáceres José Antonio , Soza Herrera Juan José
Published: January 2023

La pandemia priorizó la inserción de las prácticas educativas en el mundo de la tecnología, condición sine qua non del proceso de enseñanza – aprendizaje, enfocándose en la didáctica asumida por los docentes universitarios. La presente investigación se valió de un análisis sistemático de investigaciones obtenidas en bases de datos como Scopus, Web of Science, Scielo, Redalyc, Dialnet y el repositorio Renati, con la finalidad de mostrar cuál es el estado del arte de la didáctica universitaria, considerando las nuevas metodologías empleadas por los docentes universitarios en una modalidad completamente remota. Los resultados mostraron la predominancia de dos ejes temáticos: el contexto de la disrupción pedagógica universitaria, y el desarrollo y comprensión de la didáctica universitaria para reformar la educación remota.
El aprendizaje basado en problemas para el logro de competencias en educación superior.
Authors: Palomino Alca Julia Teresa , Osorio Vidal Víctor Gilberto
Published: January 2023

El artículo tiene como propósito realizar la revisión bibliográfica en relación al Aprendizaje Basado en Problemas-ABP, desde diversas perspectivas. En los dos últimos años, debido al aislamiento social y la existencia de la Pandemia COVID-19, a nivel mundial, los estudiantes han recurrido a diversas formas de aprendizaje virtual existentes, haciendo uso de diferentes estrategias, con la finalidad de poder superar las deficiencias presentadas. En educación, las escuelas y los hogares tuvieron que adecuarse a esta modalidad de enseñanza. En educación superior, los docentes de diversas carreras aplicaron estrategias y metodologías, una de ellas, el ABP consiste en presentar una situación problemática al estudiante, a fin de resolverlo aplicando sus habilidades, conocimientos, destrezas y actitudes, generando un aprendizaje significativo.
Desempeño docente en plataformas virtuales y satisfacción de clases online: Un panorama desde la percepción de universitarios peruanos.
Authors: Flores Rivera Roy Amit , García-Pisconte Silvia Karina , Gavez Jeri Nery Yaneth
Published: January 2023

Con el objetivo de identificar la relación entre el desempeño docente en las plataformas virtuales y la satisfacción de clases online en estudiantes universitarios, se sometió a estudio a 326 estudiantes peruanos a quienes se les aplicó dos encuestas: E-teach performance in virtual environments y satisfacción de clases online, encontrando en su aplicación que estas dos variables se relacionan de manera directa y significativa con un R Spearman 0,845; además, dentro del análisis se demuestra que la percepción del desempeño docente por parte de los alumnos genera satisfacción de clases online.
Análisis de la protección de datos personales en las redes sociales.
Authors: Acurio Hidalgo Germán Fabricio , Maldonado Cando Jose Luis , García Quezada Génesis Andrea , Cabrera Granda Johanna Rocío
Published: January 2023

Esta investigación analizó el precedente jurisprudencial ecuatoriano No. 2064-14-EP/21, la cual garantiza la protección de los datos personales, a la imagen, el derecho a la intimidad y el buen nombre en las redes sociales, ya que con los datos personales se puede vincular a un individuo de forma equivocada. El objetivo es analizar los cambios que ha desarrollado la protección de datos personales por el ordenamiento jurídico de hábeas data. Se emplearon los métodos de investigación documental, interpretativo, exegético, descriptivo, el método histórico-lógico, la técnica de recolección de información fueron los datos estadísticos, la encuesta y la entrevista. Se llegó a la conclusión que el hábeas data aparece con el fin de proteger los datos personales en todos los aspectos, y que no es limitada.
Aprendizaje del inglés utilizando herramientas híbridas en educación superior Hispanoamérica: revisión sistemática.
Authors: Valera Yataco Patricia , Camasca Macedo Charles Dummar , Valera Yataco Jessica del Pilar
Published: January 2023

Los nuevos escenarios educativos exigen competencias digitales en la enseñanza de los cursos tradicionales e indispensables como el idioma inglés; por ello, es necesario que los docentes universitarios obtengan metodologías, estrategias y herramientas para el desarrollo de su actividad. En ese sentido, la presente investigación evidencia la importancia del empleo de herramientas híbridas en el desarrollo de habilidades como la lectura, escritura, habla y escucha en los cursos de inglés dirigidos a universitarios en Hispanoamérica. Para ello, el presente estudio cualitativo se vale del método de revisión sistemática exploratoria de fuentes como: Web of Science, Scopus, Redalyc, Scielo y Renati. Además, esta metodología se respaldada por el Preferred Reporting Items Systematic Reviews and Meta – Analyses (PRISMA).
El uso de las redes sociales virtuales en alumnos universitarios y su afectación en la percepción de in/seguridad.
Authors: Arriaga Avalos Leonardo David , Montaño Borboa Ismael de Jesús , Landero Pérez Carolina
Published: January 2023

La criminalidad evoluciona constantemente y esto se ve reflejado en sus afectaciones, pues las plataformas donde se proyectan los temas de inseguridad son las redes sociales virtuales, y en contextos contemporáneos, estas hacen la función de medios de comunicación y habitualmente los jóvenes las utilizan como medios principales para conocer lo que sucede en su entorno, sin corroborar la información que se comparte por estos medios, afectando la forma de percibir la incidencia delictiva. Este estudio analizó la relación entre el uso de las redes sociales y el sentimiento de in/seguridad en alumnos universitarios que se encuentran estudiante en la facultad de derecho y criminología de la Universidad Autónoma de Nuevo León.
Inclusión educativa de estudiantes con discapacidad visual en la educación superior: factores que favorecen y obstaculizan su ingreso y permanencia.
Authors: Graniel Ramírez Daniela , Ramos González Blanca Lilia , Gutiérrez Valencia Ariel
Published: January 2023

El presente artículo se enfoca en analizar la inclusión de los estudiantes con discapacidad visual (ECDV). Las instituciones de educación superior tienen la responsabilidad social de facilitar la incorporación de estas minorías al ámbito profesional, ya que no poseen otras alternativas de formación, por lo que el objetivo fue analizar por medio de un estudio de caso e historia de vida un estudiante de educación superior, estableciendo los factores de inclusión educativa en su ingreso y permanencia en la universidad y su vida cotidiana; la metodología utilizada fue cualitativa, tomando como instrumento una entrevista estructurada y observación, donde dio como resultado que el ECDV presentó limitaciones durante su ingreso y permanecía en su proceso educativo.
Competencias digitales de los servidores públicos en Perú.
Authors: Medina Esquivel Wilfredo Alexander , Cernaqué Miranda Ofelia Carol , Sandoval Vargas Cecilia Margarita , Medina Sandoval Rubén Alexander
Published: January 2023

El objetivo del artículo es brindar insumos para mejorar el debate sobre la necesidad de identificar esta brecha de conocimiento, que parece afectar la implementación de la estrategia de transformación digital; es así, como previamente se ha revisado bibliografía del contexto internacional, la que ha permitido comparar el desarrollo del gobierno digital en Perú con el resto de los países de nuestra región. Asimismo, se ha revisado el marco normativo en Perú orientado a la transformación digital y los datos existentes de la brecha actual de competencias digitales de los servidores públicos; sin embargo, no existe esta línea base en Perú, y la falta de conocimiento sobre los beneficios que brinda la tecnología puede generar resistencia al cambio de los trabajadores.
Influencia del entorno psicosocial en la adecuación de los servicios ofertados por hoteles para contribuir a la resiliencia del sector turístico ante la crisis provocada por la pandemia COVID 19.
Authors: Espinet Vázquez Salvador Felipe , Sánchez Gutiérrez María Elena , De la Yncera Hernández Nadiosly De la Caridad
Published: January 2023

El objetivo es proponer un modelo de servicios ofertados por hoteles, integrado como un paquete personalizado, adecuado a las condiciones de su entorno psicosocial, propiciando la resiliencia del sector turístico ante la crisis provocada por la pandemia COVID 19. Resultado de una investigación, en el paradigma post positivista, que mediante consulta a expertos complementada con benchmarking, obtuvo información para configurar los paquetes, definir infraestructura espacio funcional y administrativa del hotel, integrando los componentes de la cadena de valor del negocio del turismo. El modelo permite su adecuación a las condiciones del entorno psicosocial específico del destino turístico, tipo de turista y procedencia. Sirve de referencia para la capacitación y formación de competencias en el dominio afectivo del personal del hotel.
Formación de competencias requeridas por profesionistas vinculados a programas de desarrollo urbano de ciudades costeras para la reducción de su vulnerabilidad y la elaboración de planes de contingencia para la resiliencia social.
Authors: Sánchez Gutiérrez María Elena , Espinet Vázquez Salvador Felipe , De la Yncera Hernández Nadiosly de la Caridad
Published: January 2023

Se determinan las competencias requeridas por profesionistas que se vinculen a programas de desarrollo urbano de ciudades costeras, para que sean capaces de encontrar las causas que provocan su vulnerabilidad ante el peligro de desastres naturales provocados por huracanes y penetraciones del mar y considerar, con enfoque sistémico y de proyecto, las inversiones en construcción y la preparación de la población, para facilitar así, la resiliencia social. El trabajo es resultado de una investigación documental de los autores sobre la formación de competencias de estudiantes de las carreras de Arquitectura e Ingeniería Civil en el tema del desarrollo urbano sustentable de ciudades costeras y el estudio de casos de proyectos considerados fallidos o no sustentables en ciudades costeras del Caribe.
Indicador número de pacientes por enfermera como política de salud; por la calidad de la atención en un hospital de tercer nivel.
Authors: Dimas Altamirano Bárbara , Maciel Vilchis Alejandra Del Carmen , Cuevas Peñaloza María Antonieta , Chaparro Ramírez Karen , Guadarrama Pérez Liliana Antonia , Ortiz Cabrera Guadalupe
Published: January 2023

La Organización Mundial de la Salud establece que un sistema de salud abarca cualquier actividad que está encaminada a promover, restablecer y mantener la salud, y que se encuentran en el nivel de organización social y se forman ante la necesidad de responder a los problemas y necesidades de salud y enfermedad a partir de la estructura económica y política de cada sociedad. El presente trabajo pretende demostrar el índice real de pacientes por enfermera a través de la investigación de acción participativa; se realizó en un servicio de medicina interna de un hospital de tercer nivel, por atender a pacientes con patología crónica degenerativa, pacientes inestables, graves y críticos.
Los tratamientos de ortodoncia y anomalías descubiertas en la revisión de radiografías de pacientes.
Authors: Menéndez Oña Lourdes Elizabeth , Miranda Anchundia Andrea Katherine , Sánchez Loor Fausto Andrés
Published: January 2023

El presente estudio tiene como objetivo estudiar las maneras de lograr diagnosticar este tipo de afecciones, mediante exámenes efectivos y complementarios. Normalmente, estas patologías las detectamos mediante rayos X o por medio de un estudio más avanzado como las tomografías. Se concluyo que las radiografías panorámicas son una de las exploraciones más utilizadas en odontología y se caracterizan por su capacidad para evaluar el maxilar, la mandíbula y las estructuras adyacentes y facilitar el diagnóstico clínico, ayudando así a detectar las afecciones silenciosas de una forma rápida y fácil.
Diagnóstico y tratamiento del VIPoma o cólera pancreático.
Authors: Mayorga Garcés Alejandro Sebastián , Borja Vega Gabriela Paola , Sánchez Palacios Carol Estefanía
Published: January 2023

El objetivo de este estudio es poder considerar al VIPoma dentro de los diagnósticos diferenciales de patologías que provoquen trastornos graves que pudieran poner en riesgo la vida de los pacientes. El VIPoma es un tumor dependiente de la cola del páncreas que provoca el deterioro clínico del paciente, presentando varios síntomas, por lo cual es conocido como cólera pancreático. Es un tumor de alto riesgo de metástasis con silencioso desarrollo, convirtiéndose en peligroso. Esta investigación se llevó a cabo basándonos en información actualizada de bases de datos electrónicas médico-científicas. Es de suma importancia su diagnóstico temprano.
Manejo integral del trauma abdominal cerrado en el servicio de emergencias de acuerdo con la guía ATLS (apoyo vital avanzado en trauma) en el Hospital General Manta durante el periodo marzo 2020 - marzo 2021.
Authors: Barrera Vera Pierina , Cedeño Revelo Priscila
Published: January 2023

El Hospital General Manta según las políticas del Ministerio de Salud Pública, es un hospital de segundo nivel de alta complejidad, y en sus competencias está el brindar atención al trauma en la zona centro y sur de Manabí. El trauma abdominal tiene una morbimortalidad significativa, ya que las lesiones abdominales representan entre el 20 y el 35% de las causas de muerte en el traumatizado. El principal objetivo de este estudio es conocer el manejo del trauma abdominal cerrado en dicho hospital e identificar errores que se cometen basándose en las normas del ATLS (Advanced Trauma Life Support). Es importante la identificación de estos errores, ya que al reconocerlos y mejorarlos se pueden obtener resultados favorables para el paciente.
Inversión uterina no puerperal en mujer adulta mayor. A propósito de un caso.
Authors: Valera Valero Carlos Alberto , Escariz Borrego Liliam Iris , Vera Moreira Alipio Armando , Sánchez Casas Yoandra
Published: January 2023

La inversión uterina es una entidad que en el área de ginecología no se presenta con mucha frecuencia; a pesar de ello, es considerada como una emergencia. La forma no puerperal se describe en situaciones relacionadas a tumores benignos o malignos del cuerpo uterino. Se presenta el caso de una paciente de 63 años que acude a consulta con cuadro clínico caracterizado por dolor en hipogastrio intenso tipo cólico y sangrado vaginal de 15 días de evolución. Al examen físico ginecológico se evidencia tumoración a nivel vaginal con tejido necrótico y coágulos. Se solicita resonancia magnética nuclear, obteniendo como diagnóstico inversión uterina, por lo que se le realiza histerectomía abdominal con evolución favorable.
Enterocolitis necrotizante en neonatos sometidos a nutrición enteral. Revisión de la literatura.
Authors: Andrade Castro Anghelo Patricio , Chávez Alcívar Raúl de Jesús , Loor Loor Natalia Maritza , Pérez Vélez Karla María
Published: January 2023

El presente estudio es una revisión sistemática de literatura de tipo analítica, descriptiva, cuantitativa y retrospectiva mediante la revisión de la evidencia científica disponible. El periodo neonatal es el periodo de tiempo comprendido desde el nacimiento hasta los primeros 28 días de vida, tiempo en el cual experimenta una mayor susceptibilidad a factores como la inmadurez de su sistema inmunológico. La revisión de la literatura permitió un análisis profundo de la evidencia científica disponible en los últimos 5 años. Los resultados determinan una asociación de la nutrición enteral con la aparición de enterocolitis necrotizante que sea superior a los beneficios que se obtienen de la implementación de la nutrición enteral.
Complicaciones en pacientes con COVID-19 atendidos en el Hospital General Manta del Instituto Ecuatoriano de Seguridad Social.
Authors: Bravo Solórzano María Claudia , Macias Vera Lissette Aracely , Moreira Vinces Ruth Ydalinda , Bravo Saquicela Diana Maribel
Published: January 2023

El objetivo del trabajo es determinar las complicaciones más frecuentes en pacientes con COVID-19 ingresados en el Hospital General IESS Manta. El estudio se basó en una revisión exhaustiva de la literatura e investigación observacional, obteniendo como resultados que las complicaciones más frecuentes en pacientes con ventilación mecánica invasiva fueron: neumonía nosocomial con un 24,18% y barotrauma con un 7,69%; de los pacientes ingresados, el 82% necesitaron oxígeno complementario, el 9% necesitó ventilación mecánica y el 8% no requirió oxígeno. Entre las comorbilidades asociadas estuvieron diabetes 29%, insuficiencia renal 20%, hipertensión arterial 39%, y obesidad 11%. Las complicaciones más frecuentes observadas en pacientes con COVID-19 estuvieron relacionadas con la presencia de más de un factor de riesgo.
Aspectos socioeconómicos y su determinación producto de la actividad camaronera en la parroquia Puerto Jelí del cantón Santa Rosa.
Authors: Uriguen Aguirre Patricia Alexandra , Ramírez Porras Jelenny Tatiana
Published: January 2023

El objetivo de la presente investigación es conocer los aspectos socioeconómicos positivos o negativos, y su determinación como producto de la actividad camaronera en la parroquia Puerto Jelí del cantón Santa Rosa. La metodología aplicada responde a una investigación descriptiva y transversal, con la aplicación de encuesta a una muestra de 88 personas relacionadas con la actividad camaronera y que habitan en Puerto Jelí. Los resultados de la investigación evidencian que los impactos de la acuicultura no se relacionan únicamente con el ambiente biofísico, sino que se extienden a través de la sociedad. Los impactos sociales varían considerablemente, dependiendo de la forma en que la acuicultura y las políticas, si existen, orienten su desarrollo.
Publicaciones científicas sobre organismos evaluadores para las instituciones y los profesionales del turismo en México.
Authors: Patricia Rocha Norma , Roux Oropeza Dora Luisa , Constantino Vázquez Alejandra Guadalupe
Published: January 2023

La acreditación de la carrea de turismo y sus profesionales, es un aspecto poco investigado. El objetivo general fue conocer la cantidad de publicaciones empíricas y teóricas, la adscripción institucional, la nacionalidad y el idioma sobre organismos evaluadores para las instituciones y los profesionales del turismo en México. El método fue un diseño de investigación no experimental, de tipo transversal y descriptivo. El universo estuvo conformado por 23,820 publicaciones, de los cuales a CLACSO le correspondieron 583; a Redalyc 6,731; y al Google Académico 16,506. Como conclusiones principales, se indica: solo dos publicaciones cumplieron con los criterios establecidos, que la Universidad Autónoma del Estado de México destaca por sus publicaciones y por la revista adscrita a esta institución.
Association of Development Disparity, Economic Growth on Poverty in South Sulawesi Province
Authors: Widjaja Imelda , Deddy T. Tikson  , Rahmadanih
Published: December 2022

The problem of regional development disparity, economic growth and poverty has always been a strategic issue in regional development. Although the direction of the association differs in each region depending on trends in regional development disparity, economic growth and poverty. The purpose of this research is to analyze the association of development disparity between regions, the rate of economic growth to poverty in South Sulawesi Province, with period 2004 – 2019. This study used simple linear regression analysis. The result study is the level of regional development disparity is significant and positively associated with the poverty rate in South Sulawesi. The rate of economic growth has a significant negative association with the poverty rate in South Sulawesi. The variable that has the greatest association with the poverty rate in South Sulawesi Province is the variable of development disparity
The Corelation of Pandemic and Indonesia Presidency of G20 in The Capital Market G20 Member Countries
Authors: Benita Rahma Tri
Published: December 2022

The correlation between the capital market of G20 member countries is important to analyze.Depending on a country’s economy, capital market integration may have different effects. A more intensebilateral relationship (trade intensity) can significantly affect the movement of capital market sharesbetween countries. The current research used the Multivariate GARCH Model/DCC-GARCH method. Thecondition of capital market integration before the Indonesian G20 Presidency showed that Indonesia(JKSE) had the strongest integration with Australia (ASX) (0.563814) and South Korea (KOSPI) (0.542470).After the G20 presidency, Indonesia (JKSE) had the strongest capital market integration with India (NSE)(0.507229) and the USA (NYSE). It was also found that China (SSE) had an integration with South Korea(KOSPI), while Germany (DAX) and Australia (ASX) had an integration with the UK (FTSE100). Theconclusion is that the higher autocorrelation, the higher the effect of the volatility of stock marketmovements in the two countries involved. Furthermore, capital market integration can be influenced bygeospatial and economic relations.
How Different Geographical Areas React to Covid19 Shock : Regional Resilience and Structural Transformation
Authors: Maftukhah Siti , Dwi Pramono Retno Widodo
Published: December 2022

In the last 10 years, Covid19 has emerged as an important recent shock that has had an effect on the globaleconomy. Regional resilience may have an effect on how different regions are affected. This study intends tolook at how regional resilience is affected by structural change both before and after Covid19. We identify twodifferent situations (prior to and during the Covid19 shock) that affect whether structural reform increasesregional resilience. The findings show that Covid19 has a number of negative effects on regional resilience.Additionally, raising a sector's productivity has a significant positive effect on resilience under typical conditions(prior to Covid19). A sector's increased productivity and contemporaneous workforce transfer to other sectorswith higher productivity during the COVID19 shock, however, have a significant beneficial effect on regionalresilience. Therefore, when the circumstance is stable, productivity becomes more crucial. However, amid ashock, the industry and its employees' flexibility and agility are more crucial.
How to Cope With Strategic Infrastructure Disparities in West Java? (A Post-Pandemic Economic Recovery Analysis )
Authors: Laksana Satya , Muchlish Al Rahmat Angga
Published: December 2022

The availability of energy and telecommunication facilities has been claimed as two strategic infrastructures supporting the West Java economy during and the post-pandemic. However, researchers found that the West Java electricity and telecommunication infrastructure is inter-regionally inequitable. This paper aims to identify the recent electrical energy access of households and the existing condition of telecommunication infrastructure; to configure the investment data in the last five years, and to analyze the opportunities and challenges of investment, and development of electricity and telecommunication network in the future. This research uses the Desk Study method by collecting primary data from bureaucrats and secondary data from relevant Government agencies. The results show that electricity and telecommunications infrastructure conditions in West Java are still unequal between the Northern and Southern regions, particularly in terms of electrification ratio, cellular phone signal strength, and internet signal quality. Furthermore, investment in West Java was very unequal, with about two-thirds of foreign and domestic investment in Bekasi and Karawang districts in the last-five-years. This study formulates recommendations for policy in the investment, electricity, and telecommunications sectors in dealing with interregional infrastructure development disparities as well as economic challenges during and after the pandemic.
Spatial Spillover Impact of Sectoral Government Expenditure on Poverty Alleviation in South Kalimantan Province
Authors: Novitasari Mega , Aditya Iskandar Doddy
Published: December 2022

Poverty is still one of the forefront issues in developing countries. It could hamper the achievement ofsustainable development goals, thereby triggering a recurring call on the government's role in mitigatingpoverty. This paper contributed to the debate on the role of sectoral government spending under thefiscal decentralization policy to combat poverty. Using a case study in South Kalimantan Province, weemployed a spatial panel data analysis covering 13 districts from 2010-2020. This study investigated thepresence of spatial dependency on poverty and the spatial spillover impact of government expenditure—education, health, housing, public facilities, and social protection—on poverty. The research found theexistence of spatial autocorrelation on poverty and the significant high-cluster poverty in the agriculture-based region. The direct estimation from the Spatial Durbin Model uncovered that governmentexpenditure on education, health, and social protection significantly alleviated poverty, while housing andpublic facilities expenditure remained insignificant in reducing the poverty rate. Besides, educationspending also has a significant indirect effect on poverty, indicating the spatial spillover impact ofeducation spending by the neighbors on poverty in a region.
Peran Gereja dalam Mempersiapkan Utusan Injil ke Daerah-daerah di Indonesia: Sebuah Pemikiran Misiologis
Authors: Hermanto Yanto Paulus , Gultom Hizkia David Asaf , Howardy Kenny Gracia , Manullang Tomi Fransiskus
Published: December 2022

Hasil survei menunjukkan bahwa gereja kurang berperan dalam mengutus utusan Injil ke daerah-daerah. Hal ini sangat memprihatinkan pelaksanaan amanat agung Kristus. Oleh sebab itu penulis melakukan penelitian bagaimana agar peran gereja maksimal dalam mengutus utusan Injil ke daerah-daerah. Metode untuk menjawab pertanyaan penelitian ini, penulis menggunakan pendekatan kualitatif. Pembahasan dalam karya tulis ini meliputi penyamaan persepsi mengenai utusan Injil, pentingnya Gereja melakukan pengutusan, dan bagaimana gereja memilih dan mengutus utusan Injil. Dari pembahasan ini diperoleh peran gereja yang seharusnya dalam pengutusan utusan Injil ke daerah-daerah.
Solidaritas Yesus Terhadap Disabilitas: Suatu Implikasi Praktis Solidaritas Gereja Terhadap Kaum Disabilitas
Authors: Darius Darius , Kasinda Filia Amelia
Published: December 2022

Abstrak

Manusia merupakan makhluk sosial yang membutuhkan sesamanya, utamanya mereka yang memiliki keterbatasan. Menghadirkan rumah dan kehangatan bagi mereka dalam bentuk solidaritas menjadi wujud pengakuan eksistensi mereka di tengah-tengah masyarakat. Dasar dari pemberlakuan solidaritas dalam Kekristenan adalah teladan dan pengajaran Yesus. Hal ini perlu terimplikasi dalam kehidupan Gereja masa kini. Oleh sebab itu, penelitian ini akan meneliti Solidaritas Yesus bagi penyandang disabilitas: sebuah implikasi praktis solidaritas gereja terhadap penyandang disabilitas. Metode penelitian yang digunakan ialah jenis kualitatif dengan pendekatan literatur, yaitu buku-buku, jurnal dan dokumen lainnya. Hasil dari penelitian ini ialah, Pertama Dasar dari solidaritas dalam Kekristenan ialah teladan dan pengajaran Yesus. Kedua, kehadiran gereja sebagai bentuk implikasi praktis dari teladan dan pengajaran Yesus dalam membangun solidaritas bagi penyadang disabilitas.