bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on polyurethane-based porous materials and their adsorption properties
Authors: LI Jiajia , ZHU Jiahui , GU Jialin , ZHOU Zhenhao , SUN Qi , GUO Guangcan , ZHOU Yibin , CHEN Shujun , SHAN Xinggang , WANG Gangqiang
Published: April 2023

The flexible superhydrophobic thermoplastic polyurethane(TPU) porous   material was prepared by heat-induced phase separation method with two cooling steps. The influence of the preparation process on the microstructure of the material was discussed in depth. The microstructure, hydrophobicity and specific surface area of porous TPU materials were analyzed in detail. The surface wettability, separation selectivity, saturated adsorption capacity and adsorption rate, mechanical properties, environmental adaptability and cyclic properties of porous TPU materials were studied.The results show that the TPU-8% porous monolithic material prepared by heat-induced phase separation method shows good performance when the polymer concentration is 8%, the phase separation temperature is 0°C, the phase separation time is 30min, and the mixing solvent ratio is 9:1.
One dimensional terpyridine-based metal organic framework for stable supercapacitor
Authors: FENG Haoxuan , LI Weiqi , MA Chenyu , HE Haiyan
Published: April 2023

In summary, a novel structure of MOF based on 1,4–di ([2,2':6',2''terpyridin] -4'-yl)benzene and 1,4-naphthalenedicarboxylic acid has been constructed through hydrothermal reaction. The Ni-MOF displays one dimensional zigzag chain, which connect each other by hydrogen bonding to form three dimensional supramolecule with large channels. The conjugated systems of the terpyridin and benzene ligands enhance the chain rigidity, accelerate the electron transport. The massive channels provides electrolyte rapid transfer. By the structural feature aforementioned, the Ni-MOF demonstrates stable electrochemical performance as suprocapacitor.
Randomized phase II study of weekly carfilzomib 70 mg/m2 and dexamethasone with or without cyclophosphamide in relapsed and/or refractory multiple myeloma patients
Authors: Puertas Borja , González-Calle Verónica , Sureda Anna , Moreno María José , Oriol Albert , González Esther , Rosiñol Laura , López Jordi , Escalante Fernando , Martínez-Lopez Joaquín , Carrillo Estrella , Clavero Esther , Ríos-Tamayo Rafael , Rey-Bua Beatriz , González-Rodríguez Ana Pilar , Dourdil Victoria , De Arriba Felipe , González Sonia , Pérez-de-Oteyza Jaime , Hernández Miguel T. , García-Mateo Aránzazu , Bargay Joan , Bladé Joan , Lahuerta Juan José , San Miguel Jesús F. , Ocio Enrique M. , Mateos María-Victoria
Published: April 2023

In this randomized phase II study (GEM-KyCyDex, clinicaltrials gov. Identifier: NCT03336073), the combination of weekly carfilzomib 70 mg/m2, cyclophosphamide and dexamethasone (KCd) was compared to carfilzomib and dexamethasone (Kd) in relapsed/refractory multiple myeloma (RRMM) after 1-3 prior lines (PL). One hundred and ninety-seven patients were included and randomized 1:1 to receive KCd (97 patients) or Kd (100 patients) in 28-day cycles until progressive disease or unacceptable toxicity occurred. Patient median age was 70 years, and the median number of PL was one (range, 1-3). More than 90% of patients had previously been exposed to proteasome inhibitors, approximetely 70% to immunomodulators, and approximetely 50% were refractory to their last line (mainly lenalidomide) in both groups. After a median follow-up of 37 months, median progression-free survival (PFS) was 19.1 and 16.6 months in KCd and Kd, respectively (P=0.577). Of note, in the post hoc analysis of the lenalidomide-refractory population, the addition of cyclophosphamide to Kd resulted in a significant benefit in terms of PFS: 18.4 versus 11.3 months (hazard ratio =1.7, 95% confidence interval: 1.1-2.7; P=0.043). The overall response rate and the percentage of patients who achieved complete response was around 70% and 20% in both groups. The addition of cyclophosphamide to Kd did not result in any safety signal, except for severe infections (7% vs. 2%). In conclusion, the combination of cyclophosphamide with Kd 70 mg/m2 weekly does not improve outcomes as compared with Kd alone in RRMM after 1-3 PL, but a significant benefit in PFS was observed with the triplet combination in the lenalidomide-refractory population. The administration of weekly carfilzomib 70 mg/m2 was safe and convenient, and, overall, the toxicity was manageable in both arms.
Plasma rico en plaquetas y plasma gel en cicatrización por segunda intención en conejos
Authors: Sánchez Cedeño Alvaro Francisco , Aguilar Caivinagua Andrés Santiago , Castillo Hidalgo Edy Paul
Published: April 2023

Objetivo. El objetivo de la investigación fue evaluar el efecto del plasma rico en plaquetas y plasma gel en cicatrización de heridas por segunda intención en conejos. Metodología.  Se utilizó 8 conejos (Oryctolagus cuniculi) de entre 12 a 24 meses de edad, aparentemente sanos, machos y hembras, con un peso de entre 3.5 a 4.5 kg, a los cuales se realizó 3 heridas de 2 cm de diámetro, asignando un diferente tipo de tratamiento a cada una: Tratamiento 1 (T1): plasma gel; Tratamiento 2 (T2): plasma rico en plaquetas; Tratamiento 3 (T3): placebo como control. Se realizaron biopsias a los días 7, 14 y 21 de iniciado el tratamiento para valorar el grado de inflamación, reepitelización, neovascularización, depósito de colágeno, fibroplasia, contaminación bacteriana y contaminación fúngica. Resultados. Al día 7 de iniciados los tratamientos se obtuvo un incremento significativo en el grado de inflamación de las lesiones de T1. Para el día 14 los valores de depósito de colágeno fueron estadísticamente mayores para T3. Al día 7 y 14 la fibroplasia fue mayor para T2 y T3 en comparación a T1.  Conclusiones. Las heridas tratadas por segunda intención con el uso plasma rico en plaquetas y plasma gel mejoran entre los 7 a 15 días de tratamiento, reduciendo el grado de inflamación y aumentando el depósito de colágeno en comparación a tratamientos placebo. Entre el uso de Plasma rico en plaquetas y Plasma gel se obtuvieron mejores resultados de los parámetros de cicatrización para las heridas tratadas con Plasma gel, sobre todo al día 15 de iniciado los tratamientos. Área de estudio: medicina veterinaria, salud animal, dermatología.
Tác động của quy mô nhóm du lịch tới mối quan hệ giữa trải nghiệm du lịch đáng nhớ và ý định quay lại điểm đến của khách du lịch nội địa trong du lịch cộng đồng ở Việt Nam
Authors: Nguyễn Thị Hoài Dung , Trần Thị Thu Huyền
Published: April 2023

Lý thuyết tác động xã hội của Latané (1981) cho rằng số lượng nguồn tác động trong một tình huống có thể ảnh hưởng tới trải nghiệm cũng như hành vi của những người tham gia tình huống đó. Điều này gợi ý rằng quy mô nhóm du lịch có thể ảnh hưởng tới những trải nghiệm du lịch đáng nhớ cũng như ý định quay lại điểm đến của khách du lịch. Nhóm nghiên cứu đã kiểm định tác động của quy mô nhóm du lịch tới mối quan hệ giữa trải nghiệm du lịch đáng nhớ và ý định quay lại điểm đến của khách du lịch nội địa trong du lịch cộng đồng ở Việt Nam. Kết quả thu được từ mẫu gồm 618 quan sát cho thấy trải nghiệm du lịch đáng nhớ giải thích 84,2% ý định quay lại điểm đến của khách du lịch nội địa là người Việt Nam đi du lịch theo nhóm có quy mô từ 08 người trở lên và tỷ lệ này thấp hơn đối với những khách du lịch nội địa là người Việt Nam đi du lịch theo nhóm có quy mô từ 07 người trở xuống.
ATAGI Targeted Review 2021: the national COVID-19 vaccination program
Authors: Jayasinghe Sanjay , Patel Cyra , Armstrong Lucy , Chiu Clayton , Macartney Kristine , Flanagan Katie , Gibney Katherine , Giles Michelle , Crawford Nigel , Cheng Allen , Blyth Chris
Published: April 2023

The overarching goal of the Australian coronavirus disease 2019 (COVID-19) vaccination program has been to protect all people in Australia from the harm caused by the novel coronavirus SARS-CoV-2. This review reflects on the role of the Australian Technical Advisory Group on Immunisation (ATAGI) in the national COVID-19 vaccination program, in terms of the initial programmatic and clinical recommendations in the evolving context of evidence relating to the disease and vaccines, epidemiology, and the program rollout. To fulfil the obligation to provide evidence-based advice to the Minister for Health and Aged Care on the safe, effective and equitable use of COVID-19 vaccines, ATAGI has worked closely with other agencies and committees such as the Therapeutic Goods Administration (TGA) and the Communicable Diseases Network Australia. ATAGI recommendations have sought to optimise the use of the available vaccine doses in achieving the objectives of preventing serious illness and death from COVID-19 while addressing any emerging safety signals following program commencement on 22 February 2021. As of mid-November 2021, the use of COVID-19 vaccines in children aged 5 to 11 years was being considered by the TGA and ATAGI; and emerging evidence, in areas such as use of heterologous vaccine schedules and co-administration with other vaccines, was under review. Despite unprecedented challenges which the delivery of mass COVID-19 vaccination presented to health systems globally, in Australia much was achieved in 2021 with over 90% coverage for primary doses in the vaccine-eligible population. Evaluation, using high quality data and assessment methods, of vaccination program outcomes—such as coverage, vaccine effectiveness and impact—is key to determine whether program objectives have been achieved and where gaps remain. Reflecting on the lessons learned so far would help further improve the national COVID-19 vaccination program and would also benefit programs for other routine vaccines and planning for future pandemics.
Using silent area analysis to inform a COVID-19 public health response in Hunter New England, regional New South Wales
Authors: Butler Michelle , Elton Benjamin , Durrheim David
Published: April 2023

In 2020 and 2021, in the context of nationwide efforts to suppress SARS CoV-2 virus transmission while awaiting a vaccine, public health teams were responsible for finding and isolating all cases and quarantining their contacts. The success of this strategy required very high case ascertainment and thus, by inference, ready access to PCR testing, even in large rural areas such as Hunter New England in New South Wales. ‘Silent area’ analysis entailed the scheduled regular comparison of case and testing rates at local-government-area resolution against larger area and state-wide rates. This analysis provided an easily understood metric for identifying areas with lower testing rates, and for direction of surging of local testing capacity in such areas, by the local health district in partnership with public health services and private laboratory services. Complementary intensive community messaging was also utilised to promote increased testing in identified areas.
PELATIHAN PEMBUATAN ALAT PERAGA MOTOR LISTRIK SEDERHANA KEPADA SISWA DI SMA DARUSSALAM CIPUTAT
Authors: Faradiba
Published: April 2023

Prodi Pendidikan fisika adalah satu-satunya prodi Pendidikan fisika di DKI Jakarta yang memiliki visi untuk menerapkan pembelajaran menggunakan media yang dihasilkan dari bahan-bahan yang sederhana. Sehingga prodi Pendidikan fisika akan menerapkan ilmu yang dikuasai ke sekolah-sekolah sebagai bentuk pengabdian dan transfer ilmu pengetahuan. Prodi pendidikan fisika FKIP UKI melakukan pelatihan pembuatan alat peraga  motor listrik sederhana kepada siswa di SMA Darussalam ciputat, Tangerang. Pelatihan ini dilakukan sebagai upaya prodi dalam pengimplementasian kepahlian dalam bentuk kegiatan  pengabdian kepada masyarakat. Kegiatan ini akan dilakukan pada hari Selasa, 6 September 2022 di SMA Darussalam Ciputat, Tangerang. Program yang dilakukan yaitu: (1) Melakukan sosialisasi tentang alat peraga sains yang dapat dihasilkan dari barang bekas maupun bahan sederhana yang mudah ditemukan; (2) Melakukan praktikum/percobaan alat peraga yang sudah dibuat (motor listrik); (3) Melakukan pembelajaran dengan mengaitkan konsep materi dengan hasil percobaan yang telah dilakukan dengan menggunakan alat peraga yang dihasilkan. Pengabdian Kepada Masyarakat ini dapat menjadi salah satu sarana dalam peningkatan dan pengembangan kreatifitas siswa dan guru dalam proses Pembelajaran.

Kata Kunci: Motor listrik sederhana, Siswa, SMA Darussalam.
Peningkatan Pemahaman Iman Kristen Melalui Program Penyuluhan di Kalangan Siswa SMA dan SMK Yadika Soreang
Authors: Simanjuntak Ferry , Alexander Christopher , Christianto Josef , Mulyadi Jeremy
Published: April 2023

Setiap orang perlu memiliki pemahaman yang jelas mengenai iman yang dianutnya. Demikian juga seorang Kristen perlu memiliki pemahaman iman yang benar. Itu sebabnya, kegiatan pengabdian kepada masyarakat ini dilakukan guna meningkatkan pemahaman iman Kristen melalui program pemuridan di kalangan siswa SMA dan SMK Yadika Soreang, di mana selama 7 (tujuh) hari, dipaparkan materi mengenai Jaminan Keselamatan, Pertobatan, Yesus Penguasa Tunggal, Pemulihan Hati Bapa, Pemulihan Gambar Diri, Kesembuhan Luka Batin, Menikmati Alkitab, Kehidupan Doa, Love, Sex and Dating, Panggilan Hidup, Sejarah Gereja: Gereja Mula-mula, Sejarah Gereja: Aliran dalam Kekristenan, Kuasa Perkataan, dan Toleransi Umat Beragama.
Penguatan Sikap Positif Perempuan Kristen dalam Keluarga, Gereja dan Masyarakat
Authors: Jovani Audra
Published: April 2023

Negara berkewajiban untuk melindungi warga negaranya baik laki-laki maupun perempuan dalam berbagai aspek kehidupan termasuk di dalam keluarga sebagai bagian terkecil, dan di komunitas gereja maupun di masyarakat sebagai bagian terbesar. Perempuan dan laki-laki pun memiliki kedudukan yang sama dalam segala bidang yang memiliki akses, partisipasi, kontrol dan manfaat dari pembangunan bagi dirinya sendiri maupun keluarganya. Gereja sebagai komunitas spiritual menjadi tempat yang penting dalam mengembangkan kehidupan rohani maupun bermasyarakat bagi perempuan dan laki-laki. Namun demikian, perempuan sering kali berpikir bahwa gereja merupakan tempat untuk kehidupan pribadi saja antara dia dengan Sang Pencipta, walaupun sesungguhnya gereja dapat menjadi tempat atau komunitas yang mampu memberikan perempuan akses, partisipasi, kontrol dan manfaat bagi kehidupannya sebagai pribadi maupun kelompok. Selain itu, di komunitas gereja ini, perempuan dapat mengembangkan kemampuan dan sikap positif dalam dirinya untuk dirinya sendiri, keluarga dan lingkungannya. Melalui kegiatan pengabdian kepada masyarakat ini, ketua pengusul dan anggota lainnya melakukan peningkatan kesadaran perempuan mengenai pentingnya perempuan memiliki sikap positif dalam keluarga, gereja dan masyarakat. Perempuan memiliki kesempatan dan mampu berperan besar bagi dirinya sendiri, keluarga, gereja, dan masyarakatnya. Kegiatan ini dilakukan pada Sabtu, 30 Juli 2022 di Gereja HKBP Filadelfia Bekasi dengan peserta sebanyak 80 anggota jemaat yang terdiri dari perempuan dan laki-laki. Kegiatan ini dimulai dengan penyadaran dan sosialisasi pentingnya sikap positif perempuan Kristen dalam keluarga, gereja dan masyarakat. Melalui kegiatan ini muncul kesadaran perempuan dan laki-laki anggota jemaat untuk mampu bersikap positif dalam segala aspek kehidupan.

 

Kata Kunci: sikap positif; perempuan Kristen; keluarga; gereja; masyarakat.
Pelatihan Senam Asma Menuju Desa Sehat
Authors: Handayani RahmaNova
Published: April 2023

The problem that arises at this time is that the level of health for villagers is not yet optimal because the role of health cadres is not optimal, especially health problems that are not contagious (non-communicable disease) such as asthma. Asthma can not be cured but can be controlled either with drugs or without drugs. One of the recommended management of asthma without drugs by WHO and the Global Initiative for Asthma (GINA) is exercise or physical exercise. Asthma gymnastics is a recommended physical exercise in Indonesia and many studies have been carried out both on increasing lung capacity function and improving quality of life. The solution to the problems raised in this community service will train cadres to understand more about asthma and asthma exercise training which will be given for 3 months a week 3 times every Friday, Saturday and Sunday to health cadres so that it is hoped that there will be a special place for patients asthma to improve quality of life. Friday and Saturday are used for training health cadres on asthma exercise, and Sunday for people with asthma. The target of this community service is health cadres and people with asthma consisting of 56 people, 11 health cadres and 45 people with asthma. The results of the service obtained data, 11 cadres were able to do asthma exercise independently and people with asthma experienced an increase in their quality of life. The measuring instrument used for the quality of people with asthma is the Asthma Quality of Life Questionnaire (AQLQ)
Peningkatan Pengetahuan dan Praktikum Dasar-Dasar Microsoft Office di Panti Asuhan Abdi Agape Pontianak
Authors: Sihombing Daniel Oktodeli , Fitri Yutika  , Saragih Fry Melda
Published: April 2023

Pengabdian Kepada Masyarakat (PKM) yang dilaksanakan oleh Tim PKM Institut Teknologi dan Bisnis Sabda Setia (ITBSS) merupakan kegiatan Pelatihan Dasar Microsoft Office Di Panti Asuhan Abdi Agape Pontianak. Kegiatan ini telah dilaksanakan selama tiga sesi dalam waktu dua hari, yaitu pada tanggal 8 dan 9 Oktober 2022. Kegiatan Pengabdian Kepada Masyarakat ini diikuti oleh 19 orang peserta yang merupakan anak-anak asuh di Panti Asuhan Abdi Agape Pontianak. Pelatihan Dasar Microsoft Office ini terdiri dari tiga topik pelatihan mengenai Microsoft Word, Microsoft Excel dan Microsoft PowerPoint. Materi-materi tersebut akan dimentoring oleh dosen-dosen dari Institut Teknologi dan Bisnis Sabda Setia. Berdasarkan hasil evaluasi dan analisis terhadap nilai Pre-test dan Post-test kegiatan Pengabdian Kepada Masyarakat ini berhasil memberikan pemahaman bagi peserta pelatihan, serta meningkatkan kemampuan anak-anak asuh di Panti Asuhan Abdi Agape Pontianak. Pada Pelatihan Dasar dan Praktik Microsoft Word ini nilai rata-rata Post-test peserta di pelatihan tersebut meningkat 30.05% dari nilai rata-rata Pre-test mereka. Kemudian untuk Pelatihan Dasar dan Praktik Microsoft Excel, nilai rata-rata Post-test peserta di pelatihan tersebut meningkat 21.82% dari nilai rata-rata Pre-test mereka. Sedangkan untuk sesi terakhir yaitu pelatihan dasar Microsoft PowerPoint, nilai rata-rata Post-Test peserta di pelatihan tersebut meningkat 30.24%. Berdasarkan hasil test yang menunjukan peningkatan ini, dapat dikatakan bahwa tujuan dan manfaat dari Kegiatan Pengabdian Kepada Masyarakat yang dilakukan di Panti Asuhan Abdi Agape Pontianak ini telah tercapai.

Kata Kunci: Pengabdian Kepada Masyarakat; Microsoft Office; Word; Excel dan PowerPoint.
Kegiatan Belajar dan Bermain Bersama Siswa-Siswi SD Kampung Tugu, Desa Cibeureum, Kecamatan Cugenang
Authors: Sormin Elferida , Naibaho Lamhot , Samosir Christina Metallica , Zai Sri Wahyuni , Tarigan Steven Empindonta
Published: April 2023

Bencana gempa bumi yang terjadi di Cianjur pada bulan Desember Tahun 2022 masih menyisakan duka yang mendalam bagi warga Cianjur secara khusus di Kecamatan Cugenang yang mana beberapa desa yang menjadi pusat gempa telah memporakporandakan pemukiman warga dan menelan korban luka bahkan korban meninggal. Berbagai bantuan dari semua pihak telah diberikan, misalnya dari pemerintah, institusi perguruan tinggi dan juga lembaga sosial masyarakat. UKI salah satu perguruan tinggi swasta yang juga berperan serta dalam memberikan bantuan kepada warga terdampak, secara khusus UKI mengambil lokasi di Kampung Tugu, Desa Cibeureum, Kecamatan Cugenang. Bantuan UKI dilakukan secara bertahap dengan menurunkan tim sumber daya manusia yang dibutuhkan di lapangan, seperti tim Kesehatan, Pendidikan, Teknik dan lainnya. Kebutuhan utama warga pada saat tanggap darurat menjadi prioritas utama UKI seperti pemeriksaan kesehatan, pemberian obat dan makanan sehat bagi anak, lansia dan ibu hami, pengadaaan instalasi air bersih meliputi pengeboran air, pemasangan toren penampung air dan pemasangan MCK Portable. Selain itu juga dilakukan kegiatan psikologi healing bagi anak-anak dan lansia. Saat ini situasi sudah semakin membaik seiring dengan berjalannya waktu dan selesainya masa tanggap darurat, semua warga sudah mulai berbenah dan bantuan pun berangsur-angsur berhenti dari berbagai pihak. Namun beberapa permasalahan masih tetap dialami oleh warga yang tempat tinggalnya belum selesai dibangun oleh pemerintah, termasuk sekolah SD yang memiliki jumlah siswa sekitar 480 orang, mereka terpaksa masih harus mengikuti pembelajaran di tenda darurat oleh karena gedung sekolah yang masih belum siap dibangun. Berkaitan dengan hal tersebut, Tim LPPM UKI bersamaan dengan adanya kegiatan Monev oleh LLDikti III bersepakat untuk kembali melihat kondisi masyarakat di loasi terdampak gempa. UKI kembali ke lokasi semula yaitu di Kampung Tugu Desa Cibeureum dan melakukan kegiatan lanjutan dari kegiatan PkM sebelumnya yang kali ini menyasar anak-anak SD dengan memberikan pembelajaran menarik ketika Belajar di tenda darurat. Hasil dari kegiatan PkM antaralain sangat antusiasnya anak-anak mengikuti pembelajaran, walaupun dalam sussana bulan Ramadhan dimana anak-anak menjalankan puasa. Anak-anak didampingi orangtua dan guru menyampaikan perasaan senang mereka oleh karena kunjungan tim UKI untuk yang kesekian kalinya.

Kata Kunci: Belajar; Bermain; Pembelajaran Menarik; Bencana Gempa; Kampung Tugu; Ciureum; Cugenang.
БІКАМЕРАЛІЗМ ЯК СКЛАДОВА РОЗВИТКУ ПАРЛАМЕНТАРИЗМУ: ТЕОРЕТИКО-ПРАВОВИЙ АСПЕКТ
Authors: Магновський І. Й.
Published: April 2023

У статті висвітлено в теоретико-правовому аспекті сутнісні характеристики бікамералізму, з огляду на дослідження юридичної науки. Акцентовано увагу на доктринальних підходах трактування бікамералізму як політико-правового феномену. Наголошено на усвідомленні бікамералізму як одного з інституційних механізмів забезпечення розподілу влади. Виділено основні функції бікамерального парламенту, серед яких: створення механізмів стримувань і противаг у системі державної влади; забезпечення політичної стабільності; захист прав регіонів; політичний арбітраж; поліпшення якості законотворчого процесу; утвердження верховенства права та демократії. Звернено увагу на популяризацію теоретичного осмислення та практики впровадження бікамералізму як одну з провідних тенденцій генезису сучасного конституціоналізму. Указано на світову практику функціонування двопалатних парламентів, де основними перевагами бікамерального парламенту є: сприяння широкому взаємоконтролю, співпраці палат, що належно підвищує зобов’язання депутатів; створення умов для фахового і відповідального обговорення законопроєктів, їх наукової, матеріальної, фінансової аргументації; відповідність вимогам професійного представництва; зменшення конфліктів між парламентом та урядом, а також сприяння раціональному розв’язанню конфліктів, гарантій проти «авторитарності» парламенту; вираження як загальнодержавних і територіальних інтересів. Означено сутність двопалатної структуризації сучасних парламентів, яка полягає в розмежуванні їх функціонального призначення: нижні палати цих парламентів мають на меті забезпечення народного представництва і здійснення якісного законотворення, а верхні – здійснюють представництво територій і традиційних регіональних еліт. Підсумовано, що бікамералізм в умовах розвитку сучасного парламентаризму є складним, багатогранним явищем, одним із показників якісного рівня громадянської зрілості суспільства, який відповідає засадам демократизації та децентралізації влади, що є затребуваними в сучасних умовах, оскільки визначають перспективи розвитку громадянського суспільства в контексті європейських цінностей і це сприятиме європеїзації та оптимальній інтеграції держави до країн-лідерів.
КРИМІНАЛЬНІ ПРАВОПОРУШЕННЯ, ЯКІ ПОСЯГАЮТЬ НА БІОЛОГІЧНУ БЕЗПЕКУ УКРАЇНИ
Authors: Шамсутдінов О. В.
Published: April 2023

У статті досліджено нове для вітчизняної кримінально-правової доктрини питання кримінально-правової охорони біологічної безпеки України. Запропоновано авторську концепцію об’єднання в єдину систему кримінальних правопорушень, які посягають на біологічну безпеку України, зокрема суспільні відносини у сфері забезпечення біологічної безпеки України розглядати як родовий об’єкт таких кримінальних правопорушень. Визначено зміст понять «біологічна безпека» та «загрози біологічного походження (біозагрози)». Запропоновано поділяти біозагрози за спрямованістю на безпосередні та опосередковані. Окреслено види людської діяльності, яка є біологічно небезпечною, та сформульовано визначення кримінальних правопорушень проти біологічної безпеки. Вироблено єдиний критерій – створювану протиправним діянням загрозу біологічного походження для об’єкта кримінально-правової охорони, на підставі якого виокремлено в Особливій частині Кримінального кодексу України конкретні склади кримінальних правопорушень, котрі можна віднести до посягань на біологічну безпеку України. Відповідно до спрямованості біозагроз посягання на біологічну безпеку України згруповано у кримінальні правопорушення, що формують безпосередні (ст.ст. 113, 130, 131, 133, 142, 247, 251, 325, 326, 439, 441 КК України) та опосередковані біозагрози (ст.ст. 236; 237; 239; 241; 242; 243; 253; 261; 440; ч. 2 ст. 268 КК України). Кожну групу кримінальних правопорушень проти біологічної безпеки, залежно від характеру посягань, умовно поділено на три підгрупи, проаналізовано їх склади. Наведені авторські визначення понять «зараження» і «забруднення». Висловлено застереження, що з усіх виділених кримінальних правопорушень лише деякі є безумовними посяганнями на біологічну безпеку України, а решта поєднують у собі суспільно небезпечний вплив на людину чи довкілля за допомогою як біологічних, так і фізичних, хімічних та інших чинників. Зроблено висновок, що Кримінальний кодекс України не забезпечує повною мірою кримінально-правову охорону суспільних відносин у сфері забезпечення біологічної безпеки України, запропоновано конкретні напрямки криміналізації небезпечних генетичних маніпуляцій, що створюють біологічні загрози.
Entendiendo la Terapia de Aceptación y Compromiso: Estado actual y Bases teóricas
Authors: Paliza Olivares Victor Fabrizzio
Published: April 2023

El presente escrito otorga una revisión completa y actualizada de las bases teóricas, filosóficas y procedimentales de la terapia de Aceptación y Compromiso. En un primer momento, se muestra brevemente el estado actual de la terapia y su eficacia en distintas condiciones físicas y psicológicas. En un segundo momento, se incursiona en los aspectos histórico-culturales que la fundamentan, se prioriza el sufrimiento humano, el dolor crónico y la hiper-reflexividad. Seguido a ello, se presentan las bases filosóficas y teóricas con hincapié al contextualismo funcional y la teoría de marco relacional. Finalmente, se aborda la teoría de la propia terapia y su modelo de aplicación.
The HRA Organ Gallery affords immersive superpowers for building and exploring the Human Reference Atlas with virtual reality
Authors: Bueckle Andreas , Qing Catherine , Luley Shefali , Kumar Yash , Pandey Naval , Börner Katy
Published: April 2023

The Human Reference Atlas (HRA, https://humanatlas.io) funded by the NIH Human Biomolecular Atlas Program (HuBMAP, https://commonfund.nih.gov/hubmap) and other projects engages 17 international consortia to create a spatial reference of the healthy adult human body at single-cell resolution. The specimen, biological structure, and spatial data that define the HRA are disparate in nature and benefit from a visually explicit method of data integration. Virtual reality (VR) offers unique means to enable users to explore complex data structures in a three-dimensional (3D) immersive environment. On a 2D desktop application, the 3D spatiality and real-world size of the 3D reference organs of the atlas is hard to understand. If viewed in VR, the spatiality of the organs and tissue blocks mapped to the HRA can be explored in their true size and in a way that goes beyond traditional 2D user interfaces. Added 2D and 3D visualizations can then provide data-rich context. In this paper, we present the HRA Organ Gallery, a VR application to explore the atlas in an integrated VR environment. Presently, the HRA Organ Gallery features 55 3D reference organs, 1,203 mapped tissue blocks from 292 demographically diverse donors and 15 providers that link to 6,000+ datasets; it also features prototype visualizations of cell type distributions and 3D protein structures. We outline our plans to support two biological use cases: on-ramping novice and expert users to HuBMAP data available via the Data Portal (https://portal.hubmapconsortium.org), and quality assurance/quality control (QA/QC) for HRA data providers. Code and onboarding materials are available at https://github.com/cns-iu/hra-organ-gallery-in-vr.
Enhancement of ZnO@RuO2 bifunctional photo-electro catalytic activity toward water splitting
Authors: Aleksić Katarina , Stojković Simatović Ivana , Stanković Ana , Veselinović Ljiljana , Stojadinović Stevan , Rac Vladislav , Radmilović Nadežda , Rajić Vladimir , Škapin Srečo Davor , Mančić Lidija , Marković Smilja
Published: April 2023

Catalytic materials are the greatest challenge for the commercial application of water electrolysis (WEs) and fuel cells (FCs) as clean energy technologies. There is a need to find an alternative to expensive and unavailable platinum group metal (PGM) catalysts. This study aimed to reduce the cost of PGM materials by replacing Ru with RuO2 and lowering the amount of RuO2 by adding abundant and multifunctional ZnO. A ZnO@RuO2 composite in a 10:1 molar ratio was synthesized by microwave processing of a precipitate as a green, low-cost, and fast method, and then annealed at 300°C and 600°C to improve the catalytic properties. The physicochemical properties of the ZnO@RuO2 composites were investigated by X-ray powder diffraction (XRD), Raman and Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), UV-Vis diffuse reflectance spectroscopy (DRS), and photoluminescence (PL) spectroscopy. The electrochemical activity of the samples was investigated by linear sweep voltammetry in acidic and alkaline electrolytes. We observed good bifunctional catalytic activity of the ZnO@RuO2 composites toward HER and OER in both electrolytes. The improved bifunctional catalytic activity of the ZnO@RuO2 composite by annealing was discussed and attributed to the reduced number of bulk oxygen vacancies and the increased number of established heterojunctions.
Solvent and solvation effects on reactivities and mechanisms of phospho group transfers from phosphate and phosphinate esters to nucleophiles
Authors: Onyido Ikenna , Obumselu Onyeka F. , Egwuatu Chinyelu I. , Okoye Nkechi H.
Published: April 2023

Organophosphorus esters fulfil many industrial, agricultural, and household roles. Nature has deployed phosphates and their related anhydrides as energy carriers and reservoirs, as constituents of genetic materials in the form of DNA and RNA, and as intermediates in key biochemical conversions. The transfer of the phosphoryl (PO3) group is thus a ubiquitous biological process that is involved in a variety of transformations at the cellular level such as bioenergy and signals transductions. Significant attention has been paid in the last seven decades to understanding the mechanisms of uncatalyzed (solution) chemistry of the phospho group transfer because of the notion that enzymes convert the dissociative transition state structures in the uncatalyzed reactions into associative ones in the biological processes. In this regard, it has also been proposed that the rate enhancements enacted by enzymes result from the desolvation of the ground state in the hydrophobic active site environments, although theoretical calculations seem to disagree with this position. As a result, some attention has been paid to the study of the effects of solvent change, from water to less polar solvents, in uncatalyzed phospho transfer reactions. Such changes have consequences on the stabilities of the ground and the transition states of reactions which affect reactivities and, sometimes, the mechanisms of reactions. This review seeks to collate and evaluate what is known about solvent effects in this domain, especially their effects on rates of reactions of different classes of organophosphorus esters. The outcome of this exercise shows that a systematized study of solvent effects needs to be undertaken to fully understand the physical organic chemistry of the transfer of phosphates and related molecules from aqueous to substantially hydrophobic environments, since significant knowledge gaps exist.
Genetic characterization of human echinococcosis in Southern Punjab, Pakistan
Authors: Basharat Nosheen , Khan Jadoon , Ullah Irfan , Shah Aamer Ali , Ali Ijaz
Published: April 2023

Introduction

Echinococcosis is a neglected tropical zoonotic infection that affects both the human and livestock populations. In Pakistan, the infection is long-standing, but data on its molecular epidemiology and genotypic characterization in the southern Punjab region are limited. The aim of the current study was the molecular characterization of human echinococcosis in southern Punjab, Pakistan.

Methods

Echinococcal cysts were obtained from a total of 28 surgically treated patients. Patients’ demographic characteristics were also recorded. The cyst samples were subjected to further processing to isolate DNA in order to probe the Nad1 and Cyt-b genes, followed by DNA sequencing and phylogenetic analysis for genotypic identification.

Results

The majority of the echinococcal cysts were from male patients (60.7%). The liver was the most commonly infected organ (60.71%), followed by the lungs (25%), spleen (7.14%), and the mesentery (7.14%). Molecular and genotypic identification through sequencing and phylogenetic tree analysis showed that most of the cysts (24/28, 85.7%) were caused by the species Echinococcus granulosus sensu stricto (E. granulosus s.s.) (G1 and G3), followed by Echinococcus multilocularis (E. multilocularis) and Echinococcus canadensis (E. canadensis) (G6/G7) (3/28, 10.8%, and 1/28, 3.5%, respectively).

Conclusion

The current study concluded that the majority of human infections were caused by E. granulosus s.s., followed by the E. multilocularis and E. canadensis species (G6/G7). Genotypic characterization among both human and livestock populations is needed to explore the genetic diversity of echinococcosis.
Cardioprotective effects of shock wave therapy: A cardiac magnetic resonance imaging study on acute ischemia-reperfusion injury
Authors: Petrusca Lorena , Croisille Pierre , Augeul Lionel , Ovize Michel , Mewton Nathan , Viallon Magalie
Published: April 2023

Introduction

Cardioprotection strategies remain a new frontier in treating acute myocardial infarction (AMI), aiming at further protect the myocardium from the ischemia-reperfusion damage. Therefore, we aimed at investigating the mechano-transduction effects induced by shock waves (SW) therapy at time of the ischemia reperfusion as a non-invasive cardioprotective innovative approach to trigger healing molecular mechanisms.

Methods

We evaluated the SW therapy effects in an open-chest pig ischemia-reperfusion (IR) model, with quantitative cardiac Magnetic Resonance (MR) imaging performed along the experiments at multiple time points (baseline (B), during ischemia (I), at early reperfusion (ER) (∼15 min), and late reperfusion (LR) (3 h)). AMI was obtained by a left anterior artery temporary occlusion (50 min) in 18 pigs (32 ± 1.9 kg) randomized into SW therapy and control groups. In the SW therapy group, treatment was started at the end of the ischemia period and extended during early reperfusion (600 + 1,200 shots @0.09 J/mm2, f = 5 Hz). The MR protocol included at all time points LV global function assessment, regional strain quantification, native T1 and T2 parametric mapping. Then, after contrast injection (gadolinium), we obtained late gadolinium imaging and extra-cellular volume (ECV) mapping. Before animal sacrifice, Evans blue dye was administrated after re-occlusion for area-at-risk sizing.

Results

During ischemia, LVEF decreased in both groups (25 ± 4.8% in controls (p = 0.031), 31.6 ± 3.2% in SW (p = 0.02). After reperfusion, left ventricular ejection fraction (LVEF) remained significantly decreased in controls (39.9 ± 4% at LR vs. 60 ± 5% at baseline (p = 0.02). In the SW group, LVEF increased quickly ER (43.7 ± 11.4% vs. 52.4 ± 8.2%), and further improved at LR (49.4 ± 10.1) (ER vs. LR p = 0.05), close to baseline reference (LR vs. B p = 0.92). Furthermore, there was no significant difference in myocardial relaxation time (i.e. edema) after reperfusion in the intervention group compared to the control group: ΔT1 (MI vs. remote) was increased by 23.2±% for SW vs. +25.2% for the controls, while ΔT2 (MI vs. remote) increased by +24.9% for SW vs. +21.7% for the control group.

Discussion

In conclusion, we showed in an ischemia-reperfusion open-chest swine model that SW therapy, when applied near the relief of 50′ LAD occlusion, led to a nearly immediate cardioprotective effect translating to a reduction in the acute ischemia-reperfusion lesion size and to a significant LV function improvement. These new and promising results related to the multi-targeted effects of SW therapy in IR injury need to be confirmed by further in-vivo studies in close chest models with longitudinal follow-up.
Clinical trial-identified inflammatory biomarkers in breast and pancreatic cancers
Authors: Peng Jing , Madduri Supradeep , Clontz Angela D. , Stewart Delisha A.
Published: April 2023

Breast cancer and pancreatic cancer are two common cancer types characterized by high prevalence and high mortality rates, respectively. However, breast cancer has been more well-studied than pancreatic cancer. This narrative review curated inflammation-associated biomarkers from clinical studies that were systematically selected for both breast and pancreatic cancers and discusses some of the common and unique elements between the two endocrine-regulated malignant diseases. Finding common ground between the two cancer types and specifically analyzing breast cancer study results, we hoped to explore potential feasible methods and biomarkers that may be useful also in diagnosing and treating pancreatic cancer. A PubMed MEDLINE search was used to identify articles that were published between 2015-2022 of different kinds of clinical trials that measured immune-modulatory biomarkers and biomarker changes of inflammation defined in diagnosis and treatment of breast cancer and pancreatic cancer patients. A total of 105 papers (pancreatic cancer 23, breast cancer 82) were input into Covidence for the title and abstract screening. The final number of articles included in this review was 73 (pancreatic cancer 19, breast cancer 54). The results showed some of the frequently cited inflammatory biomarkers for breast and pancreatic cancers included IL-6, IL-8, CCL2, CD8+ T cells and VEGF. Regarding unique markers, CA15-3 and TNF-alpha were two of several breast cancer-specific, and CA19 and IL-18 were pancreatic cancer-specific. Moreover, we discussed leptin and MMPs as emerging biomarker targets with potential use for managing pancreatic cancer based on breast cancer studies in the future, based on inflammatory mechanisms. Overall, the similarity in how both types of cancers respond to or result in further disruptive inflammatory signaling, and that point to a list of markers that have been shown useful in diagnosis and/or treatment method response or efficacy in managing breast cancer could potentially provide insights into developing the same or more useful diagnostic and treatment measurement inflammatory biomarkers for pancreatic cancer. More research is needed to investigate the relationship and associated inflammatory markers between the similar immune-associated biological mechanisms that contribute to breast and pancreatic cancer etiology, drive disease progression or that impact treatment response and reflect survival outcomes.
Transformer fault diagnosis based on probabilistic neural networks combined with vibration and noise characteristics
Authors: Zhou Xiu , Luo Yan , Tian Tian , Bai Haonan , Wu Peng , Liu Weifeng
Published: April 2023

When the transformer is running, the vibration which is generated in the core and winding will spread outward through the medium of metal, oil, and air. The magnetic field of the core changes with the variation of the transformer excitation source and the state of the core, so the corresponding vibration and noise change. Therefore, the vibration and noise of the transformer contain a lot of information. If the information can be associated with the fault characteristics of the transformer, it is significant to evaluate the running state of the transformer through the vibration and noise signal, which improve the intelligence, safety, and stability of the transformer operation. Based on this, modeling and simulation of transformer multi-point grounding, DC bias, and short-circuit between silicon steel sheets fault are first carried out in this paper, and vibration and noise distribution of transformer under different faults are given. Second, a fault diagnosis method based on transformer vibration and noise characteristics is proposed. In the process of implementation, vibration and noise signals under multi-point grounding, DC bias, and short-circuit between silicon steel sheets are taken as the sample data, and the probabilistic neural network algorithm is used to effectively predict the transformer fault. Finally, the effectiveness of the proposed scheme is verified by identifying the simulation faults-the proposed fault diagnosis method based on PNN can be effectively applied to transformer.
Dung beetles (Coleoptera: Scarabaeidae) in grazing lands of the Neotropics: A review of patterns and research trends of taxonomic and functional diversity, and functions
Authors: Arellano Lucrecia , Noriega Jorge Ari , Ortega-Martínez Ilse J. , Rivera José D. , Correa César M. A. , Gómez-Cifuentes Andrés , Ramírez-Hernández Alfredo , Barragán Felipe
Published: April 2023

Dung beetles are one of the most representative groups of insects associated with livestock, as they take advantage of the manure of livestock for food and reproduction. They have been widely used as a bio-indicator group to evaluate their responses to land-use change and other environmental disturbances by analyzing species diversity at different spatial and temporal scales. However, the impacts of livestock management practices, forms, and history on dung beetle diversity are still poorly understood. This paper is an exhaustive and systematic review of the existing peer-reviewed and indexed literature on the taxonomic diversity (species richness and composition), functional diversity, and ecological functions of dung beetles from different provinces and biogeographic domains in tropical grazing lands of the Neotropics. We analyzed the timeline of the studies conducted so far, and we detected increasing literature produced mainly in South America. We included the most frequent objectives, tendencies, software, and statistical analyses. Given the significant heterogeneity of livestock landscapes in the Neotropics, the reviewed studies have conceptualized broadly what a pasture is, and the authors have used different descriptions of other grazing lands. Additionally, management data and livestock practices vary widely among studies, and management history is poorly described. In future research, it is relevant to include as much information as possible and the consequences of different livestock management practices on additional ecological attributes of dung beetle assemblages at different landscape scales (spatial and temporal) to predict how ecological processes change in Neotropical landscapes. Considering the importance of the data to be included in future work, we propose a collection format to unify the information collected in the field when conducting ecological studies in grazing lands. Moreover, we define a classification system to homogenize the features that distinguish the multiple tropical grazing lands reported in the literature. Preserving dung beetle diversity and associated ecological functions is urgent for maintaining ecosystem services in grazing lands. The challenge for research institutions is to continue filling gaps in knowledge to help those who work in transferring knowledge, to help ranchers exercise better options for more sustainable livestock farming, and to publish results for conservation decision-making.
Prevalence of hepatitis B infection and its associated factors among pregnant mothers attending antenatal care at public hospitals at Hararghe, Eastern Ethiopia
Authors: Umer Abbas , Teklemariam Zelalem , Ayele Firayad , Mengesha Melkamu Merid
Published: April 2023

Background

Hepatitis B infection is one of the world's most serious public health problems, causing significant morbidity and mortality. More than 2 billion individuals around the world have been infected with the hepatitis B virus (HBV), and approximately 400 million people are chronically infected with the virus, with more than a million dying each year from hepatitis B virus-related liver disease. A newborn infant whose mother is positive for both HBsAg and HBeAg has a 90% chance of developing chronic infection by the age of 6. Its infectivity is a 100 times that of the human immunodeficiency virus, but it receives little attention in public health. Therefore, this study was conducted to assess the prevalence of hepatitis B infection and its associated factors among pregnant mothers attending antenatal care at public hospitals in west Hararghe, eastern Ethiopia 2020.

Method

This institution-based cross-sectional study was conducted on 300 pregnant mothers selected by systematic random sampling from September to December 2020. Data were collected by face-to-face interview using a pretested structured questionnaire. A blood sample was collected and tested for hepatitis B surface antigen using the enzyme-linked immunosorbent assay test method. Data were entered into EpiData version 3.1 and exported to Statistical Package for the Social Science version 22 for analysis. Bivariate and multivariable logistic regressions were used to assess the association between outcome and predictor variables. P-value <0.05 was considered to be statistically significant.

Results

The overall seroprevalence of hepatitis B virus infection was 8% [95% confidence interval (CI): 5.3–11.0] among pregnant mothers. History of tonsillectomy [adjusted odd ratio (AOR) = 5.7; 95% CI: 1.3–23.9], tattoo (AOR = 4.3; 95% CI: 1.1, 17.0), having multiple sexual partners (AOR = 10.8; 95% CI: 2.5, 45.9), and history of contact with jaundiced patients (AOR = 5.6; 95% CI: 1.2, 25.7) were factors associated with the seroprevalence of hepatitis B virus infection among pregnant mothers.

Conclusion

The hepatitis B virus was highly prevalent. A history of tonsillectomy, tattooing, having multiple partners, and contact with jaundiced patients were factors associated with hepatitis B virus infection. To reduce HBV transmissions, the government should increase HBV vaccination coverage. All newborns should receive the hepatitis B vaccine as soon as possible after birth. It is also recommended that all pregnant women have HBsAg testing and antiviral prophylaxis to reduce the risk of transmission from mother to child. Hospitals, districts, regional health bureaus, and medical professionals should also educate pregnant women about hepatitis B virus transmission and prevention, both in the hospital and in the community, with a focus on modifiable risk factors.