bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of multi-temporal generation scheduling in power system under elevated renewable penetrations: A review
Authors: Chen Kai , Shao Qizhuan , Zhou Binbin , Yang Qiyu , Pan Hongyu , Jin Tianyu , Liu Shuangquan
Published: January 2023

The traditional power generation mix and the geographical distribution of units have faced structural reform with the increasing renewables. The existing scheduling schemes confront the optimization challenges of multi-source collaborative and multi-temporal coordination. This paper reviews the optimization of generation scheduling in power systems with renewables integration in different time scales, which are medium- and long-term, short-term and real-time, respectively. First, the scheduling model and method are summarized. The connections and differences of the multi-source mathematic model with uncertainty, as well as the market mechanism, including thermal power, hydroelectric power, wind power, solar energy, and energy storage, are also indicated. Second, the scheduling algorithm and approach are sorted out from the two dimensions of certainty and uncertainty. The innovation and difference in algorithm between the traditional scheduling and the scheduling problem with renewables are presented. Meanwhile, the interaction and coupling relationship among the different time scales are pointed out in each section. The challenges and shortcomings of current research and references future directions are also provided for dispatchers.
Design and assessment of a core-power controller for lithium-cooled space nuclear reactor based on the concept of fuzzy model predictive control
Authors: Yin Yuan , Yuan Zhenheng , Pang Bo , Xiao Yiqing , Deng Yangbin
Published: January 2023

Thanks to its unique characteristics of high power-to-mass ratio, shallow reactivity poisoning, and quick response to reactivity control, power supply system based on lithium-cooled space nuclear reactor is preferred for various exploration missions into outer and deep space. However, due to its nature of few-people or even unmanned on-duty, an intelligent autonomous control of the reactor system, especially an accurate control of the reactor core power following the demanding power output, is of vital importance for such a space nuclear reactor. In this study, a core-power controller for a megawatt ultra-small lithium-cooled space nuclear reactor was designed based on the concept of fuzzy model predictive control (FMPC) combining model predictive control and T-S fuzzy theory. Performance of the FMPC controller was simulated and assessed with the Simulink platform for five typical operation transients including ramp, step and disturbance transient. The results show that the intelligent FMPC controller possesses an excellent load-following ability and anti-interference ability, both of which are of vital importance for space exploration missions. When compared with the classical PID controller, the FMPC controller designed in this study shows also a much better performance with smaller overshoot, lesser adjusting time and lower integral time-squared error.
Biogeography of the Sunda Shelf revisited: Insights from Macaranga section Pruinosae (Euphorbiaceae)
Authors: Dixit Nadi M. , Zirpel Malte , Slik J. W. Ferry , Jamsari J. , Weising Kurt , Guicking Daniela
Published: January 2023

The Southeast Asian region of Sundaland is among the world’s major biodiversity hotspots. The region’s biodiversity coupled with its complex and dynamic geographic and climatic histories makes it an ideal region to study the various factors that determine the diversification and distribution patterns of tropical biota. Here we investigate the biogeographic patterns in the partly myrmecophyticMacarangasectionPruinosaeto reveal some of the factors that play a role in determining the distribution of biota in Sundaland. We used single nucleotide polymorphisms (SNP) data derived from GBS, a next generation sequencing technique, in maximum likelihood and cluster analyses to determine phylogenetic relationships and population structures within this taxonomic section. Bayesian inference based on secondary calibration points and ancestral area reconstruction analyses were performed to infer spatial–temporal origins of the major lineages in the section. The results from these analyses were further substantiated using nuclear microsatellite data obtained from a broader sample set of two widely distributed species within the section:Macaranga giganteaandMacaranga pruinosa. Phylogenetic and cluster analyses reveal four well-defined, discrete species groups within sectionPruinosae, all of which but one originated in Borneo with the crown node dated at 3.58 mya. Biogeographic patterns within the species reveal a biogeographic barrier between east and west Sundaland besides bringing to light the role played by various geological factors, especially the Crocker Range, on Borneo. Patterns also reveal a biogeographic barrier between the Bangka/Belitung islands and Sumatra for ant-free, swamp-adapted species. This study provides evidence that geographic barriers, edaphic conditions, and ecological adaptations are tightly linked and that their mutual interaction determines the diversification and distribution of species.
Genome-wide association mapping of bread wheat genotypes using yield and grain morphology-related traits under different environments
Authors: Ahmed Hafiz Ghulam Muhu-Din , Zeng Yawen , Khan Muhammad Ahsan , Rashid Muhammad Abdul Rehman , Ameen Muhammad , Akrem Ahmed , Saeed Amjad
Published: January 2023

Depleting water resources and increasing global temperature due to climate change are major challenges to agriculture and food security worldwide. Deciphering the underlying mechanisms of traits contributing to grain development and yield is essential for the development of climate-resilient cultivars. Therefore, this study assessed 105 bread wheat genotypes grown under control, drought, and heat-stress conditions for two crop seasons and performed a genome-wide association study (GWAS) using a 90k SNP array. The genotypes showed significant trait differences under all environmental conditions. Highly significant variation was observed, with moderate (50.09%) to high (76.19%) heritability in the studied germplasms. The studied traits were all also significantly positively correlated. A total of 541 significant associations (p ≤ 10−3) between marker and trait (MTAs) were observed after crossing the FDR <0.05 threshold for all traits. Among these, 195, 179, and 167 significant MTAs were detected under control, drought, and heat-stress conditions, respectively. Under the control and drought conditions, pleiotropic loci BS00010616_51 and BS00010868_51 were observed on chromosomes 7B and 1B situated at 186.24 cM and 35.47 cM, respectively. Pleiotropic loci BS00010868_51, Kukri_c11154_1723, and Ex_c10068_1509 were identified on chromosomes 1B, 5B, and 2A, respectively, under control and heat stress conditions. A stable and consistent locus (Excalibur_c20796_395) on chromosome 7A, located at 372.34 cM, was also linked to grain morphology and yield-related attributes in control, drought, and heat-stress conditions. The results of the current study confirmed several previously reported MTAs for the traits under consideration and identified new MTAs under harsh climatic conditions. These SNPs will aid in the discovery of novel genes in wheat. SNPs showing significant associations may be used in marker-assisted selection and allow the development of drought- and heat-tolerant genotypes with high yields to address global food security concerns.
Preclinical species gene expression database: Development and meta-analysis
Authors: Krause Caitlin , Suwada Kinga , Blomme Eric A. G. , Kowalkowski Kenneth , Liguori Michael J. , Mahalingaiah Prathap Kumar , Mittelstadt Scott , Peterson Richard , Rendino Lauren , Vo Andy , Van Vleet Terry R.
Published: January 2023

The evaluation of toxicity in preclinical species is important for identifying potential safety liabilities of experimental medicines. Toxicology studies provide translational insight into potential adverse clinical findings, but data interpretation may be limited due to our understanding of cross-species biological differences. With the recent technological advances in sequencing and analyzing omics data, gene expression data can be used to predict cross species biological differences and improve experimental design and toxicology data interpretation. However, interpreting the translational significance of toxicogenomics analyses can pose a challenge due to the lack of comprehensive preclinical gene expression datasets. In this work, we performed RNA-sequencing across four preclinical species/strains widely used for safety assessment (CD1 mouse, Sprague Dawley rat, Beagle dog, and Cynomolgus monkey) in ∼50 relevant tissues/organs to establish a comprehensive preclinical gene expression body atlas for both males and females. In addition, we performed a meta-analysis across the large dataset to highlight species and tissue differences that may be relevant for drug safety analyses. Further, we made these databases available to the scientific community. This multi-species, tissue-, and sex-specific transcriptomic database should serve as a valuable resource to enable informed safety decision-making not only during drug development, but also in a variety of disciplines that use these preclinical species.
Aestivation induces widespread transcriptional changes in the African lungfish
Authors: Niu Yuhan , Guan Lihong , Wang Cheng , Jiang Haifeng , Li Guogang , Yang Liandong
Published: January 2023

Aestivation is a special ability possessed by some animals to cope with hot and dry environments utilizing dormancy. At a macroscopic level, dormant animals stop moving and eating. At the microscopic level, the expression of a large number of genes in these animals is strictly controlled. However, little is known about what changes occur during aestivation, especially in fish. In this study, we used transcriptome analysis to examine what changes occur in the gills and lungs of the African lungfish (Protopterus annectens) during the maintenance phase of aestivation and speculated on their causes. We found that aestivating transcriptomes were highly similar between gills and lungs. We also found that some genes showed differential expression or alternative splicing, which may be associated with different organs. In addition, differential expression analysis revealed that the lungs maintained significantly higher bioactivity during aestivation, which suggests that the main respiratory organ in aestivating lungfish can transform. Our study provides a reference point for studying the relationship between aestivation and hibernation and further increases understanding of aestivation.
Numerical simulation study on suppression effect of water mist on PMMA combustion under external radiant heat flux
Authors: Zhao Lanming , Cao Dongxu , Chen Yong , Liu Hanru , You Tianchi , Li Caoyue , Zhang Hongming
Published: January 2023

Numerical model was built with fire dynamic simulator and theocratical simulation was carried out to investigate the suppression effect of water mist on ignition and combustion process of typical solid material polymethyl methacrylate under external radiant heat flux. Characteristic parameters such as ignition time, surface temperature, heat release rate and temperature distribution of flame central plane during ignition and combustion process under different thermal radiant fluxes were obtained and compared with experimental results. The suppression effect of spray droplets on ignition and combustion process was analyzed and discussed. The results show the theoretical calculations of combustion characteristic parameters are in good agreement with experimental measurements. Water mist droplets can effectively delay the ignition time. Quantitative data proves that the water mist flow rate at 0.9 L/(min·m2) can delay the ignition time of samples by about 1,100 s while the radiant heat flux is 50 kW/m2. The simulation results can provide theoretical support and data reference for typical solid material fire prevention and fire extinguishment in practice.
Dual targeting with 224Ra/212Pb-conjugates for targeted alpha therapy of disseminated cancers: A conceptual approach
Authors: Juzeniene Asta , Stenberg Vilde Yuli , Bruland Øyvind Sverre , Revheim Mona-Elisabeth , Larsen Roy Hartvig
Published: January 2023

Metastases are the primary cause of death among cancer patients and efficacious new treatments are sorely needed. Targeted alpha-emitting radiopharmaceuticals that are highly cytotoxic may fulfill this critical need. The focus of this paper is to describe and explore a novel technology that may improve the therapeutic effect of targeted alpha therapy by combining two radionuclides from the same decay chain in the same solution. We hypothesize that the dual targeting solution containing bone-seeking 224Ra and cell-directed complexes of progeny 212Pb is a promising approach to treat metastatic cancers with bone and soft tissue lesions as well as skeletal metastases of mixed lytic/osteoblastic nature. A novel liquid 224Ra/212Pb-generator for rapid preparation of a dual targeting solution is described. Cancer cell targeting monoclonal antibodies, their fragments, synthetic proteins or peptides can all be radiolabeled with 212Pb in the 224Ra-solution in transient equilibrium with daughter nuclides. Thus, 224Ra targets stromal elements in sclerotic bone metastases and 212Pb-chelated-conjugate targets tumor cells of metastatic prostate cancer or osteosarcoma. The dual targeting solution may also be explored to treat metastatic breast cancer or multiple myeloma after manipulation of bone metastases to a more osteoblastic phenotype by the use of bisphosphonates, denosumab, bortezomib or hormone therapy prior to treatment. This may improve targeting of bone-seeking 224Ra and render an augmented radiation dose deposited within metastases. Our preliminary preclinical studies provide conceptual evidence that the dual 224Ra-solution with bone or tumor-targeted delivery of 212Pb has potential to inhibit cancer metastases without significant toxicity. In some settings, the use of a booster dose of purified 212Pb-conjugate alone could be required to elevate the effect of this tumor cell directed component, if needed, e.g., in a fractionated treatment regimen, where the dual targeting solution will act as maintenance treatment.
Fermented table olives from Cyprus: Microbiota profile of three varieties from different regions through metabarcoding sequencing
Authors: Kamilari Eleni , Anagnostopoulos Dimitrios A. , Tsaltas Dimitrios
Published: January 2023

The knowledge about the microbial diversity of different olives varieties from diverse regions in the Mediterranean basin is limited. This work aimed to determine the microbial diversity of three different fermented olive varieties, collected from different regions in Cyprus, via Next Generation Sequencing (NGS) analysis. Olives were spontaneously fermented for 120 days, microbial DNA was extracted from the final products, and subjected to 16S rRNA gene and ITS1 loci metabarcoding analysis for the determination of bacterial and fungal communities, respectively. Results revealed that the bacterial profile of the studied varieties was similar, while no noteworthy differences were observed in olives from different regions. The bacterial profile was dominated by the co-existence of Lactobacillus and Streptococcus, while the genera Lactococcus and Salinivibrio and the family Leuconostocaceae were also present in increased relative abundances. Regarding fungal communities, the analysis indicated discrimination among the different varieties, especially in Kalamata ones. The most abundant fungi were mainly the genera Aspergillus, Botryosphaeria, Meyerozyma, and Zygosaccharomyces for Cypriot olives, the genera Botryosphaeria, Saccharomyces, Geosmithia, and Wickeromyces for Kalamata variety, while the dominant fungi in the Picual variety were mainly members of the genera Candida, Penicillium, Saccharomyces, Hanseniospora and Botryosphaeria. Potential microbial biomarkers that distinguish the three varieties are also proposed. Moreover, interaction networks analysis identified interactions among the key taxa of the communities. Overall, the present work provides useful information and sheds light on an understudied field, such as the comparison of microbiota profiles of different varieties from several regions in Cyprus. The study enriches our knowledge and highlights the similarities and the main differences between those aspects, booming in parallel the need for further works on this frontier, in the attempt to determine potentially olives’ microbial terroir in Cyprus. Our work should be used as a benchmark for future works in this direction.
Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine
Authors: Marileo Ana M. , Gavilán Javiera , San Martín Victoria P. , Lara Cesar O. , Sazo Anggelo , Muñoz-Montesino Carola , Castro Patricio A. , Burgos Carlos F. , Leiva-Salcedo Elías , Aguayo Luis G. , Moraga-Cid Gustavo , Fuentealba Jorge , Yévenes Gonzalo E.
Published: January 2023

The Gelsemium elegans plant preparations have shown beneficial activity against common diseases, including chronic pain and anxiety. Nevertheless, their clinical uses are limited by their toxicity. Gelsemine, one of the most abundant alkaloids in the Gelsemium plants, have replicated these therapeutic and toxic actions in experimental behavioral models. However, the molecular targets underlying these biological effects remain unclear. The behavioral activity profile of gelsemine suggests the involvement of GABAA receptors (GABAARs), which are the main biological targets of benzodiazepines (BDZs), a group of drugs with anxiolytic, hypnotic, and analgesic properties. Here, we aim to define the modulation of GABAARs by gelsemine, with a special focus on the subtypes involved in the BDZ actions. The gelsemine actions were determined by electrophysiological recordings of recombinant GABAARs expressed in HEK293 cells, and of native receptors in cortical neurons. Gelsemine inhibited the agonist-evoked currents of recombinant and native receptors. The functional inhibition was not associated with the BDZ binding site. We determined in addition that gelsemine diminished the frequency of GABAergic synaptic events, likely through a presynaptic modulation. Our findings establish gelsemine as a negative modulator of GABAARs and of GABAergic synaptic function. These pharmacological features discard direct anxiolytic or analgesic actions of gelsemine through GABAARs but support a role of GABAARs on the alkaloid induced toxicity. On the other hand, the presynaptic effects of the alkaloid provide an additional mechanism to explain their beneficial effects. Collectively, our results contribute novel information to improve understanding of gelsemine actions in the mammalian nervous system.
Prior COVID-19 infection may increase risk for developing endothelial dysfunction following hematopoietic cell transplantation
Authors: Ariagno Sydney , Ragoonanan Dristhi , Khazal Sajad , Mahadeo Kris M. , Cisneros Gabriel Salinas , Zinter Matt S. , Blacken Robyn A. , Mohan Gopi , Lehmann Leslie E. , Ferdjallah Asmaa , Mara Kristin C. , Kohorst Mira A.
Published: January 2023

Endothelial dysfunction underlies many of the major complications following hematopoietic cell transplantation (HCT), including transplant-associated thrombotic microangiopathy (TA-TMA), veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS), and engraftment syndrome (ES). Emerging evidence similarly implicates endothelitis and microangiopathy in severe COVID-19-related multi-system organ dysfunction. Given the overlap in these two illness states, we hypothesize that prior COVID-19 infection may increase risk for HCT-related endotheliopathies. This retrospective, multicenter study included patients aged 0-25 years who underwent autologous or allogeneic HCT for any indication between January 1, 2020 and September 21, 2021, with close attention to those infected with COVID-19 in either the six months prior to transplant or twelve months following transplant. Incidences of TA-TMA, VOD/SOS, and ES were compared among patients with COVID-19 infection pre-HCT and post-HCT, as well as with historical controls who were never infected with SARS-CoV-2. Those who underwent HCT following COVID-19 infection displayed significantly increased rates of TA-TMA compared to those who were never infected. Additionally, our data suggests a similar trend for increased VOD/SOS and ES rates, although this did not reach statistical significance. Therefore, a history of COVID-19 infection prior to undergoing HCT may be a nonmodifiable risk factor for endothelial-related complications following HCT. Further studies are warranted to better clarify this relationship among larger cohorts and in the era of the Omicron SARS-CoV-2 variants.
An enhanced genetic mutation-based model for predicting the efficacy of immune checkpoint inhibitors in patients with melanoma
Authors: Pan Chaohu , Tang Hongzhen , Wang Wei , Wu Dongfang , Luo Haitao , Xu Libin , Lin Xue-Jia
Published: January 2023

Background

Programmed death ligand 1 (PD-L1) and tumor mutation burden (TMB) have been developed as biomarkers for the treatment of immune checkpoint inhibitors (ICIs). However, some patients who are TMB-high or PD-L1-high remained resistant to ICIs therapy. Therefore, a more clinically applicable and effective model for predicting the efficacy of ICIs is urgently needed.

Methods

In this study, genomic data for 466 patients with melanoma treated with ICIs from seven independent cohorts were collected and used as training and validation cohorts (training cohort n = 300, validation cohort1 n = 61, validation cohort2 n = 105). Ten machine learning classifiers, including Random Forest classifier, Stochastic Gradient Descent (SGD) classifier and Linear Support Vector Classifier (SVC), were subsequently evaluated.

Results

The Linear SVC with a 186-gene mutation-based set was screened to construct the durable clinical benefit (DCB) model. Patients predicted to have DCB (pDCB) were associated with a better response to the treatment of ICIs in the validation cohort1 (AUC=0.838) and cohort2 (AUC=0.993). Compared with TMB and other reported genetic mutation-based signatures, the DCB model showed greater predictive power. Furthermore, we explored the genomic features in determining the benefits of ICIs treatment and found that patients with pDCB were associated with higher tumor immunogenicity.

Conclusion

The DCB model constructed in this study can effectively predict the efficacy of ICIs treatment in patients with melanoma, which will be helpful for clinical decision-making.
Landmark mediation survival analysis using longitudinal surrogate
Authors: Zhou Jie , Jiang Xun , Xia H. Amy , Hobbs Brian P. , Wei Peng
Published: January 2023

Clinical cancer trials are designed to collect radiographic measurements of each patient’s baseline and residual tumor burden at regular intervals over the course of study. For solid tumors, the extent of reduction in tumor size following treatment is used as a measure of a drug’s antitumor activity. Statistical estimation of treatment efficacy routinely reduce the longitudinal assessment of tumor burden to a binary outcome describing the presence versus absence of an objective tumor response as defined by RECIST criteria. The objective response rate (ORR) is the predominate method for evaluating an experimental therapy in a single-arm trial. Additionally, ORR is routinely compared against a control therapy in phase III randomized controlled trials. The longitudinal assessments of tumor burden are seldom integrated into a formal statistical model, nor integrated into mediation analysis to characterize the relationships among treatment, residual tumor burden, and survival. This article presents a frameworkfor landmark mediation survival analyses devised to incorporate longitudinal assessment of tumor burden. R2 effect-size measures are developed to quantify the survival treatment mediation effects using longitudinal predictors. Analyses are demonstrated with applications to two colorectal cancer trials. Survival prediction is compared in the presence versus absence of longitudinal analysis. Simulation studies elucidate settings wherein patterns of tumor burden dynamics require longitudinal analysis.
Remdesivir associated sinus bradycardia in patients with COVID-19: A prospective longitudinal study
Authors: Hajimoradi Maryam , Sharif Kashani Babak , Dastan Farzaneh , Aghdasi Sina , Abedini Atefeh , Naghashzadeh Farah , Mohamadifar Arezoo , Keshmiri Mohammad Sadegh , Noorali Sima , Lookzadeh Somayeh , Alizadeh Niloufar , Siri Mohammad Amin , Tavasolpanahi Mohammadali , Abdolmohammadi Yazdan , Shafaghi Masoud , Rouhani Zahra Sadat , Shafaghi Shadi
Published: January 2023

Background: Remdesivir is effective against SARS-Cov-2 with little evidence of its adverse effect on the cardiac system. The aim of the present study is investigating the incidence of bradycardia in COVID-19 patients treated with Remdesivir.

Methods: This prospective longitudinal study was conducted in a tertiary center on COVID-19 patients for Remdesivir therapy. The objectives were to investigate the incidence of sinus bradycardia, and also the association between their demographics, underlying diseases, and the disease severity with developing bradycardia in COVID-19 patients treated with Remdesivir.

Results: Of 177 patients, 44% were male. The mean (±standard deviation) age of patients was 49.79 ± 15.16 years old. Also, 33% were hospitalized due to more severe symptoms. Oxygen support was required for all hospitalized subjects. A total of 40% of the patients had comorbidities, with the most common comorbidity being hypertension. The overall incidence of bradycardia (heart rate<60 bpm) in patients receiving Remdesivir was 27%, of whom 70% had extreme bradycardia (heart rate <50 bpm). There was also a statistically significant reduction in heart rate after five doses of Remdesivir compared to the baseline heart rates. In the multivariable model, none of the covariates including age above 60 years, female sex, CRP>50 mg/L, O2 saturation<90%, underlying cardiovascular disease, hypertension and diabetes mellitus, and beta-blockers were associated with Remdesivir-induced bradycardia. No association was found between the COVID-19 severity indicators and bradycardia.

Conclusion: As sinus bradycardia is a prevalent adverse cardiac effect of Remdesivir, it is recommended that all COVID-19 patients receiving Remdesivir, be evaluated for heart rate based on examination; and in the case of bradyarrhythmia, cardiac monitoring should be performed during administration to prevent adverse drug reactions.
Women’s mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan–melatonin axis
Authors: Alcantara-Zapata D. E. , Lucero N. , De Gregorio N. , Astudillo Cornejo P. , Ibarra Villanueva C. , Baltodano-Calle M. J. , Gonzales G. F. , Behn C.
Published: January 2023

Sexual (and gender)-dimorphism in tolerance to hypobaric hypoxia increasingly matters for a differential surveillance of human activities at high altitude (HA). At low altitudes, the prevalence of anxiety and depression in women has already been found to double when compared with men; it could be expected to even increase on exposure to HA. In purposefully caring for the health of women at HA, the present work explores the potential involvement of the tryptophan (Trp)–melatonin axis in mood changes on exposure to hypobaric hypoxia. The present work highlights some already known anxiogenic effects of HA exposure. Hypoxia and insomnia reduce serotonin (5-HT) availability; the latter defect being expressed as failure of brown adipose tissue (BAT) activation and mood disorders. Rapid eye movement (REM) sleep organization and synapsis restoration that are additionally affected by hypoxia impair memory consolidation. Affective complaints may thus surge, evolving into anxiety and depression. Sex-related differences in neural network organization and hormonal changes during the menstrual cycle, and certainly also during the life cycle, underscore the possibility of 5-HT–related mood alterations, particularly in women on HA exposure. The mean brain rate of 5-HT synthesis at sea level is already 1.5-fold higher in males than in females. sexual dimorphism also evidences the overexpression effects of SERT, a 5-HT transporter protein. Gonadal and thyroid hormones, as influenced by HA exposure, further modulate 5-HT availability and its effects in women. Besides caring for adequate oxygenation and maintenance of one’s body core temperature, special precautions concerning women sojourning at HA should include close observations of hormonal cycles and, perhaps, also trials with targeted antidepressants.
Comprehensive analysis of grazing intensity impacts alpine grasslands across the Qinghai-Tibetan Plateau: A meta-analysis
Authors: Zhang Zhenchao , Zhao Yiran , Lin Hao , Li Yanpeng , Fu Jinmin , Wang Yingxin , Sun Juan , Zhao Yanhua
Published: January 2023

Livestock grazing is a dominant practice in alpine grasslands and plays a crucial role in the ecosystem service of the Qinghai-Tibetan Plateau. The effects of grazing on alpine grasslands highly depends on grazing intensity. Up to now, we still lack comprehensive understanding of the general responses of alpine grasslands to different grazing intensities over broad geographic scales across the Qinghai-Tibetan Plateau. Here, we conducted a meta-analysis to explore the responses of plant characteristics and soil properties to grazing intensity in alpine grasslands of the Qinghai-Tibetan Plateau based on 52 peer-reviewed literatures. The results showed that grazing did not change the belowground biomass, while significantly increased the ratio of root to shoot (P< 0.05). Light grazing exhibited no significant effects on the plant richness, Shannon-Wiener diversity, soil water content, soil bulk density, nutrients, microbial biomass carbon, and microbial biomass nitrogen (P > 0.05). Moderate grazing significantly increased the plant richness and Shannon-Wiener diversity, while significantly decreased the soil organic carbon and total nitrogen (P< 0.05). Heavy grazing significantly decreased the plant richness, Shannon-Wiener diversity, water content, soil organic carbon, total nitrogen, microbial biomass carbon, and microbial biomass nitrogen, and significantly increased the soil bulk density (P< 0.05). These findings suggest that overgrazing is closely associated with grassland degradation, and moderate grazing is a sustainable practice to provide animal production and simultaneously maintain ecological functions for alpine grasslands on the Qinghai-Tibetan Plateau.
Cross-cultural adaptation and psychometric evaluation of the Portuguese version of the family resilience questionnaire – short form (FaRE-SF-P) in women with breast cancer
Authors: Almeida Sílvia , Rodrigues da Silva Daniel , Frasquilho Diana , Costa Beatriz , Sousa Berta , Mourinho Baptista Telmo , Grácio Jaime , Lemos Raquel , Oliveira-Maia Albino J.
Published: January 2023

Background

A diagnosis of cancer, and the resulting treatment process, can be perceived as a life-threatening event, affecting not only patients but also their social network and, more specifically, their relatives. While the ability to cope and adjust to difficult health situations may be challenging, family resilience may optimize a positive adaptation to adversity and contribute to enhance the patient’s quality of life. The Family Resilience Questionnaire (FaRE) is a self-report measure of family resilience that assesses this construct systematically. We aimed to validate the Portuguese version of a short form of the FaRE (FaRE-SF-P) in a sample of women with breast cancer.

Methods

147 women recently diagnosed with early breast cancer were recruited at the Champalimaud Clinical Centre in Lisbon. Participants completed psychometric assessment including the Portuguese version of the FaRE-SF-P, composed by two subscales of the original version – the FaRE Perceived Family Coping (FaRE-PFC) and the FaRE Communication and Cohesion (FaRE-CC). Confirmatory factor analysis (CFA) was performed to assess the factor structure of the FaRE-SF-P. Construct validity was assessed using the Hospital Anxiety and Depression Scale (HADS) for divergent validity, and the Modified Medical Outcomes Study Social Support Survey (mMOS-SS) as well as the social functioning subscale from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) for convergent validity.

Results

The CFA results confirmed a correlated two-factor structure model consistent with the Perceived Family Coping and the Communication and Cohesion subscales. Internal consistency reliability indicated good values both for Perceived Family Coping and Communication and Cohesion subscales. The results for construct validity showed acceptable convergent and divergent validity.

Discussion

The FaRE-SF-P showed good psychometric properties demonstrating to be a valid and reliable family resilience measure to use in Portuguese women diagnosed with breast cancer. Since FaRE-SF-P is a short instrument it may be a useful screening tool in an oncological clinical practice routine.
The role of facilities management in fighting COVID-19 outbreak: Evidence from Malaysian public hospitals
Authors: Mehmood Waqas , Fareed Muhammad , Mohd-Rashid Rasidah , Ashraf Muhammad Umair , Aman-Ullah Attia
Published: January 2023

The aim of this study is to provide a holistic review of the fight against COVID-19 in developing countries, particularly Malaysia. Specifically, the study aims to determine how facilities management delivery in public hospitals can be improved to ensure readiness in handling COVID-19 cases. We conducted a review of the literature and reliable media updates on COVID-19 and services management. A critical synthesis of COVID-19 information was conducted to scrutinise the technical aspects and highlight how facilities management can be improved to ensure hospital readiness in managing COVID-19 cases. The data and information used in the present study were collected up to the time of writing this paper, which leaves a room for further studies. Nonetheless, this study’s recommendations are useful for understanding the present and future pandemics. This study is a first attempt to summarise the data on facilities management in relation to the COVID-19 pandemic in the Malaysian context. The study’s findings are suitable for the developing countries in managing healthcare management practices in the fight against COVID-19. This study aims to highlight current issues in order to provide a more objective assessment of facilities management to ensure hospital readiness in handling COVID-19 cases.
Left-behind experience and language proficiency predict narrative abilities in the home language of Kam-speaking minority children in China
Authors: Yang Wenchun , Chan Angel , Gagarina Natalia
Published: January 2023

Introduction

Studies have documented that child experiences such as external/environmental factors as well as internal factors jointly affect acquisition outcomes in child language. Thus far, the findings have been heavily skewed toward Indo-European languages and children in the Western, educated, industrialized, rich and democratic (WEIRD) societies. By contrast, this study features an understudied minority language Kam, and a group of so-called left-behind children in China growing up in a unique social-communicative environment.

Methods

Fifty-five bilingual children aged 5–9 acquiring Kam as home language were assessed using the Multilingual Assessment Instrument for Narratives (LITMUS MAIN). Twenty-three “two parents-left” children (mean age = 6;8, range: 5;0–9;2) remained in rural areas while both parents went to cities for employment, and they were raised by their grandparents. Thirty-two were “one parent-left” peers (mean age = 7;3, range: 5;0–9;3) who also resided in rural areas but were raised by one parent. Oral narrative texts were analysed for macrostructure based on story structure (SS), story complexity (SC) and internal state terms (IS). The study examined whether and how narrative production is predicted by internal factors such as chronological age and linguistic proficiency of a child and an external factor such as left-behind experience. Four measures were scored as outcome measures: SS, SC, IS type, IS token. Four measures were taken as predictors: chronological age, left-behind experience, scores in a lexical production task, and scores in a sentence repetition task tapping expressive morphosyntactic competence.

Results

Results showed that left-behind experience consistently predicted all four outcome measures, where the “two parents-left” children scored significantly lower than their “one parent-left” peers. Expressive vocabulary scores predicted three measures: SS, SC, and IS Token. Expressive morphosyntactic scores predicted SS and SC. Age, by contrast, did not predict any outcome measure.

Discussion

These findings suggested that being left-behind by both parents may be a negative prognostic indicator for the development and maintenance of heritage language abilities in ethnic minority children. We further discussed the conceptual significance of what it means for a child to be left-behind, by relating to more basic external factors in language development, including caregiver educational level, and amount of home language and literacy support by the caretakers.
Cognitive flexibility as a protective factor for empathy
Authors: Cai Zhiwei , Qi Bing
Published: January 2023

Although cognitive flexibility has always been considered essential to empathy, the relevant findings have been inconsistent. Inconsistent results may be because cognitive flexibility is a multi-level structure, while empathy is also a multilayer structure, and there are differences in how researchers define and measure cognitive flexibility. Therefore, the study explores the relationship between cognitive flexibility and empathy from a multi-dimensional perspective. This study involved 105 China students aged between 18 and 22 (M age = 20.26, SD = 2.00) who completed the Cognitive Flexibility Scale (cognitive flexibility trait, cognitive flexibility at the individual level), perspective-switching flexibility task (perspective-switching flexibility, cognitive flexibility at the cognitive level), the Interpersonal Reactivity Index scale (IRI, traits empathy), Multi-dimensional Empathy Test (state empathy), 2-back task (inhibitory control), and Stroop task (working memory). After controlling for additional variables, the results showed that: (1) Cognitive flexibility traits negatively predicted trait cognitive (IRI-PT) and affective empathy (IRI-EC). (2) The Other/Self perspective-switching flexibility negatively predicted the affective component of state empathy. (3) Cognitive flexibility traits and Other/Self perspective-switching flexibility negatively predicted empathy even after controlling for one of these. The study’s results suggested that cognitive flexibility negatively predicts empathy and is a protective factor for reducing the cost of empathy and promoting emotion regulation.
How voluntary control over information and body movements determines “what it’s like” to have perceptual, bodily, emotional and mental experiences
Authors: O'Regan J. Kevin
Published: January 2023

Two very fundamental aspects of phenomenal experiences underline the fact that they seem to have “something it’s like.” One aspect is the fact that experiences have a locus: they Can seem “external” (perceptual), “internal” (interoceptive, bodily or emotional) or “mental.” A second fundamental aspect is the imposingness of experiences. They can seem “present” to us in different ways, sometimes seeming displayed before us with “spatio-temporal presence.” Both these aspects of “what it’s like” can be identified with the degree to which we can voluntarily control what we are doing when we engage in an experience. The external/internal/mental dimension is determined by how our voluntary bodily actions can influence the sensorimotor flow of information. The degree of imposingness of experiences and their “spatio-temporal presence” Is determined by how our voluntary actions are impeded or assisted by innate, attention-grabbing mechanisms. By elucidating these two most fundamental aspects of “what it’s like,” and taken together with prior work on inter- and intra-modal differences in experiences, this article suggests a path toward a scientific theory of the “hard problem” of phenomenal consciousness, explaining why experiences feel like something rather than feeling like nothing.
Association between the risk of heart failure hospitalization and end-stage renal disease with digoxin usage in patients with cardiorenal syndrome: A population-based study
Authors: Chang Kai-Ting , Kuo Hsuan-Fu , Chang Yu-Han , Wang Yu-Tsang , Yang Lii-Jia , Niu Sheng-Wen , Kuo I-Ching , Chen Yumay , Wen Zhi-Hong , Hung Chi-Chih , Chang Jer-Ming , Lin Hugo Y.-H
Published: January 2023

Background

The management of the coexistence of heart disease and kidney disease is increasingly challenging for clinicians. Chronic kidney disease (CKD) is not only a prevalent comorbidity of patients with heart failure but has also been identified as a noteworthy risk factor for all-cause mortality and poor clinical outcomes. Digoxin is one of the commonest treatments for heart disease. There are few trials investigating the role of digoxin in patients with cardiorenal syndrome (CRS). This study aims to examine the association between digoxin usage and clinical outcomes in patients with CRS in a nationwide cohort.

Method

We conducted a population-based study that included 705 digoxin users with CRS; each patient was age, sex, comorbidities, and medications matched with three non-users who were randomly selected from the CRS population. Cox proportional hazards regression analysis was conducted to estimate the effects of digoxin on the incidence of all-cause mortality, congestive heart failure (CHF) hospitalization, coronary artery disease (CAD) hospitalization, and end-stage renal disease (ESRD).

Results

The all-cause mortality rate was significantly higher in digoxin users than in non-users (adjusted hazard ratio [aHR] = 1.26; 95% confidence interval [CI] = 1.09–1.46, p = 0.002). In a subgroup analysis, there was significantly high mortality in the 0.26–0.75 defined daily dose (DDD) subgroup of digoxin users (aHR = 1.49; 95% CI = 1.23–1.82, p<0.001). Thus, the p for trend was 0.013. With digoxin prescription, the CHF hospitalization was significantly higher [subdistribution HR (sHR) = 1.17; 95% CI = 1.05–1.30, p = 0.004], especially in the >0.75 DDD subgroup (sHR = 1.19; 95% CI = 1.01–1.41, p = 0.046; p for trend = 0.006). The digoxin usage lowered the coronary artery disease (CAD) hospitalization in the > 0.75 DDD subgroup (sHR = 0.79; 95% CI = 0.63–0.99, p = 0.048). In renal function progression, more patients with CRS entered ESRD with digoxin usage (sHR = 1.34; 95% CI = 1.16–1.54, p<0.001). There was a significantly greater incidence of ESRD in the < 0.26 DDD and 0.26–0.75 DDD subgroups of digoxin users (sHR = 1.32; 95% CI = 1.06–1.66, p = 0.015; sHR = 1.44; 95% CI = 1.18–1.75; p for trend<0.001).

Conclusion

Digoxin should be prescribed with caution to patients with CRS.
Corn distiller’s dried grains with solubles as a target for fermentation to improve bioactive functionality for animal feed and as a source for a novel microorganism with antibacterial activity
Authors: Christopher Ashish , Ostrander Jesse , Mathew Jithin , Sarkar Dipayan , Shetty Kalidas
Published: January 2023

Plant-based bioenergy by-products such as corn distillers’ dried grains with solubles (DDGS) are widely utilized as animal feed sources and feed ingredients due to their balanced nutritional profile and animal health protective functional qualities. Bioprocessing of this bioenergy by-product using beneficial lactic acid bacteria (LAB)-based fermentation strategy to improve animal-health targeted functional qualities has wider relevance for animal feed applications. In this study, liquid extracts of corn DDGS were fermented with Lactiplantibacillus plantarum and Lactobacillus helveticus. The unfermented and fermented extracts were then analyzed (at 0, 24, 48 and 72-h) for their total soluble phenolic content (TSP), phenolic profile, antioxidant activity via ABTS and DPPH radical scavenging activity, and antimicrobial activity against the gut pathogen Helicobacter pylori using in vitro assay models. Statistical differences in antioxidant activity and phenolic content were observed among the unfermented and fermented extracts. The major phenolic compounds detected in corn DDGS were gallic, dihydroxybenzoic, p-coumaric, caffeic and ferulic acid, and catechin. Antimicrobial activity against H. pylori was observed for the unfermented extracts and the antimicrobial activity was attributed to the growth of a corn DDGS-endemic culture. The culture was isolated, sequenced, and identified as Bacillus amyloliquefaciens. Results of this study indicated that processing strategies of by-products such as LAB- based fermentation of corn DDGS could affect its bioactive-linked functional qualities due to microbial interaction with the phytochemicals. Furthermore, plant by-products can serve as novel sources of beneficial microflora that have relevance in wider agriculture, food safety, and therapeutic applications.
Improvement of the ability to recover balance through versatile kinesthetic learning experiences
Authors: Matsuura Yuki , Kokubu Masahiro , Sakairi Yosuke
Published: January 2023

The purpose of the present study was to compare learners' movement variability while maintaining balance and the ability to recover balance using the kinesthetic-experiential learning (KEL) method of implicit learning and the model-mastery learning (MML) method of explicit learning. The participants were 29 healthy university students. They were randomly divided into two groups (KEL and MML). They were required to balance both knees on an exercise ball. The balancing time and the ability to recover their balance were measured using motion capture. Results indicated that balancing time was significantly improved for both learning methods. Regarding the learners' movements while maintaining balance, they maintained balance while moving in the KEL method, whereas they maintained balance by keeping the entire body stationary in the MML method. Concerning the ability to recover, the KEL method improved the balance recovery ability more effectively than the MML method. Therefore, we concluded that using the KEL method at the initial stage of learning improves learners' balance recovery ability and increases movement variability.