bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Mesin Pemipil Jagung Metode Poros Helix Kapasitas 600kg/jam Dengan Penggerak Motor Listrik
Authors: S. Achmad , Aziz Moch. , W. Prabowo Wahyu Wahyu , S. Tri Waris , Haryanto Haryanto , Slamet Agus
Published: November 2019

Jagung merupakan hasil pertanian yang menjadi pilihan mayoritas petani. Pada umumnya para petani jagung mengolah serta memipil jagung secara manual (tenaga manusia) tanpa menggunakan alat bantu mesin, sehingga memerlukan waktu yang lama. Mesin ini dirancang untuk mendesain ulang mesin pemipil jagung yang ada di Politeknik Negeri Semarang yang memiliki kapasitas produksi rendah. Tujuan penelitian  ini adalah memenuhi proses pengolahan panen jagung dimana dapat menambah produktifitas, kualitas hasil pipilan jagung. Metodologi yang digunakan adalah dari data yang diperoleh dari studi literatur, pembuatan alat, perakitan dan uji kemampuan. Proses pemipilan jagung adalah dengan cara memasukan 4 buah jagung sekaligus ke dalam dua poros pemipil dengan diameter 50 mm. Hasil yang dicapai dari pembuatan mesin ini yang dioperasikan selama 6 jam/hari adalah mampu memipil biji jagung dengan kapasitas produksi 600 kg/jam.               
FUNGSI AFEKTIF KELUARGA BERHUBUNGAN DENGAN TINGKAT STRES PADA WANITA MENIKAH USIA DINI DI PEDUKUHAN JARANAN DESA BANGUNTAPAN KABUPATEN BANTUL YOGYAKARTA
Authors: Septiningsih Yuli , Sari Dian Nur Adkhana , Timiyatun Endar
Published: November 2019

Backround:Â Family afective function is very importand to be fulfilled in a family to minimize the stress on family members, especially in woman family members who married early age.Â Objective:Â the aim of this research is to determine the relationship between family function with stress level in married couples early age in Pedukuhan Jaranan Banguntapan Bantul YogyakartaÂ Method:Â In this study using cross sectional method that is approach at one time coinciding with chi square corelation test, sampling technique use total sampling with the amount of respondents 37 woman early married.Â Results:Â There is a relationship of family afective function with stres level in woman early married age with result p value < 0,050.Â Conclusion:Â there is a relationship of family afective function with stress level in woman married of early age in Pedukuhan Jaranan Banguntapan Bantul Yogyakarta.
Identifikasi Sediaan Jamu Kuat yang Beredar di Kecamatan Banguntapan dan Pleret Kabupaten Bantul dengan Metode KLT
Authors: Umniyatul Dewi , Sambodo Dwi Kurniawati
Published: November 2019

Background: Traditional herbs are ingredients or herbs in the form of plant material, animal ingredients, mineral ingredients, galenic preparations or mixtures of these ingredients, it has been used as medicine traditionally.Objective: This study is aimed to Identify of Sildenafil Citrate on â€œJamu Kuatâ€ (Herbal Medicine) products.Methods: This type of research was descriptive and the sample was determined by quota sampling. The method used Thin Layer Chromatography (TLC) which was a physicochemical method. There were seven samples were extracted by the soxhletation method until a thick extract was obtained to be spotted in the quite phase of TLC silica gel F254. The motion phase used to identify sildenafil citrate was chloroform: ethyl acetate (6: 4). Spots detection was done by observation under UV light 366 nm and the spots that appeared were calculated of Rf value and compared with the comparable Rf value of sildenafil citrate.Results: From this study, there were samples containing sildenafil citrate. Sample C with a sample Rf value of 0.75 and sample D with Rf value of sample 0.78 and a comparable Rf of sildenafil citrate 0.77.Conclusion: The seven samples of â€œJamu Kuatâ€ contained sildenafil citrate in Banguntapan and Pleret Districts, Bantul Regency. Keywords: Jamu Kuat (Herbal Medicine), Sildenafil citrate, TLC
Kajian Independensi Bank Indonesia Dalam Kedudukannya Sebagai Bank Sentral Menurut Tinjauan Hukum Berdasarkan UUBI Nomor 3 Tahun 2004 Tentang Bank Indonesia
Authors: Savitri Dewi Lely
Published: November 2019

An independent state institution, Bank of Indonesia is a legal entity whose legal entity status is obtained through the enactment of Law (ie Law Number 23 of 1999 in conjunction with Bank Indonesia Regulation Number 3 of 2004 concerning Bank of Indonesia, which stipulates that Bank of Indonesia is an independent state institution both the Government and/or other parties are prohibited from interfering in the implementation of duties and authorities of Bank Indonesia (BI) violation of the prohibition of interference or obligation to refuse interference, threatened with imprisonment of at least 2 (two) years and maximum 5 (five) years and fine at least 2 (two) billion and a maximum of 5 (five) billion) The purpose of this study is to review the applicability of Bank of Indonesia law from the holder of monetary authority based on Bank Act/UUBI Number 3 of 2004 concerning Bank of Indonesia. Research method through descriptive with secondary data.
PENGARUH FINANCIAL LEVERAGE TERHADAP SYSTEMATIC RISK SAHAM
Authors: Rizal Rahyang , Pringgabayu Dematria
Published: November 2019

This Research examine the influence of financial leverage measure by Debt Ratio there are Degree of Financial Leverage (DFL), Debt to Total Asset (DTA) and Debt to Equity Ratio (DER) to the systematic risk (beta) of stock, and also examine the difference influence of thus debt ratio to the systematic risk (beta) of stock in normal period and in the global financial crisis in the year of 2008. This research use the data of firms in the manufacture sector which is listed on Indonesia Stock Exchange (Bursa Efek Indonesia) for the year of 2006 untill 2009. Using the purposive sampling method founded 87 firms for the sample. Research analysis use the panel data regression with General Least Square (GLS) method and 95% degree of confidence. The result of this research found that DFL, DTA and DER have a positive influence to the systematic risk (beta) of stock and also found that there is no difference influence of thus debt ratio to the systematic risk (beta) of stock in the normal period and on the global financial crisis in the year of 2008.
KAJIAN LAYANAN PERBANKAN SYARIAH DALAM MENCIPTAKAN KEPUASAN NASABAH PENYIMPAN DALAM UPAYA MENGOPTIMALKAN KONDISI LIKUIDITAS
Authors: Savitri Dewi Lely
Published: November 2019

The Birth of the Law of the Republic of Indonesia No. 10 of 1998 concerning Amendments to the Law of the Republic of Indonesia No. 7 of 1992 concerning Banking has provided a huge opportunity for the growth of Islamic banks in Indonesia, both Sharia Commercial Banks and Sharia People's Credit Banks. However, what is unfortunate in this case is that not all people understand and are aware of the ins and outs of Islamic banking practices, so that Islamic banks still have to be vigorous again in conducting socialization and promotion to all people in order to be able to compete with conventional banks in particular who do business development by opening a Sharia Business Unit (SBU). In terms of raising bank funds, banks generally rely on third party funds from customers to support fund distribution activities. Related to this, of course, bank services to customers, especially in fund management activities, must prioritize customer satisfaction so that they are always motivated to deposit their funds in the bank, so that third party fund mobilization is able to compensate for optimal fund distribution which will ultimately improve its liquidity performance through the Finance to Deposits Ratio (FDR). This FDR is used to see how far financing to customers can offset the obligation to immediately meet its short-term debt to customers who want to withdraw their money that has been used by the bank to see the ability and vulnerability of a bank
IMPACT WORKING CAPITAL TERHADAP PENINGKATAN PROFITABILITAS PADA KSU CAHAYA PERMATA
Authors: Ratna Gumilang Risa
Published: November 2019

This study aims to determine the effect of working capital on the level of profitability at KSU Cahaya Permata  (Business Multipurpose Cooperative), namely by taking secondary data and using linear data analysis to determine the extent of a creation that is simpler than the Bank in the management system or the procedure for financial management, in increasing profitability for the benefit of the company itself, the uniqueness of this research is based on the researcher to conduct research research at KSU Cahaya Permata. The results of this study are that working capital has a significant effect on profitability, because the increasing working capital increases the level of profitability.
PENGARUH KEPEMIMPINAN DAN KOMPENSASI TERHADAP KINERJA JABATAN FUNGSIONAL PEREKAYASA DI LINGKUNGAN PUSAT PENELITIAN DAN PENGEMBANGAN JALAN DAN JEMBATAN KEMENTERIAN PEKERJAAN UMUM DAN PERUMAHAN RAKYAT
Authors: Suhendar
Published: November 2019

The purpose of this study was to determine the influence of leadership and compensation on performance functional position of engineer at the agency Research and Development Center Road and Bridge of the Ministry of Public Works and Public Housing. Population in this research was 29 people of functional officer of engineer in Center of Research and Development of Road and Bridge. Data were obtained from census. Data collections were collected through questionnaires in the form of questions or statements distributed to all respondents to be answered or filled.

The results of research on the Influence of Leadership and Compensation on the Performance of Functional Position of Engineers in the Environment of Center of Research and Development of Road and Bridge, showed that: (1) Leadership variable (X1) has a strong positive effect on performance of functional position of engineer (Y) equal to 36,5%. (2) The compensation variable (X2) has a positive but very weak effect on the performance of the functional position of the engineer (Y) of 3%. (3) Leadership and compensation variables affect simultaneously to the performance, with correlation coefficient R = 0.612 or determinant R2 of 0.375 or 37.5%. Thus, leadership and compensation should be able to create boosting working conditions personal comfort or environmental factors that will improve employee performance.
Improving Quality of Water from Murchison bay Using Clay from Chelel, Kapchorwa District, Uganda
Authors: I. Z. Mukasa-Tebandeke , I. Karume , H. Z. Wasajja , R. Nankinga
Published: November 2019

Pollution resulting from increased human activities is threatening Lake Victoria, its effects are characterized by eutrophication, high turbidity, pH, iron(II) concentration and chemical oxygen demand (COD). In this study we have investigated the effect of Fe-montmorillonite clay from Chelel on turbidity, pH, concentration of iron, total suspended soils, total nutrients and COD of water sampled from Murchison bay watershed of Nakivubo channel south of Kampala. Varying amounts of clay powder was vigorously stirred with water samples for 5 minutes, filtered using Whatman paper at ambient temperatures. The optimum concentration of clay of 0.4 gL-1 was found to produce 73.5+2% fall in COD indicating elimination of microbes and organic waste. The pH of water became 6.3+ 0.2 showing that impurities had been bound to clay. The TSS and nutrients in MB water also decreased greatly when clay was stirred with water at ambient temperatures. The available data can be relied on to recommend use of this clay in treatment of waste water and/or sewage from Kampala. Further studies on combined use of clays with alums, zeolites and/or lime need to be carried out.
The Intellectualisation of the Malay Language in Interreligious Dialogue
Authors: Fikri Nordin Munif Zarirruddin
Published: November 2019

The Malay language is the national language of Malaysia’s multireligious and multiracial society. Due to a close association between Islam and Malay, the Muslim hegemony controls the religious truth of the meaning and interpretation in the Malay language. However, to enhance the role of the Malay language to be an inclusive religious language, it is important to intellectualise the language through interreligious dialogue in Malaysia. The study aims at (1) analysing the needs of the intellectualisation of the Malay language as a religious language in Malaysian interreligious dialogue, and (2) explaining the process of the intellectualisation of the Malay language in Malaysian interreligious dialogue. The main approaches of the study are Syed Hussein Alatas (1977) idea of intellectualism in the sociology of development and Asmah Haji Omar (1993) suggestion of intellectualisation in language planning. There are two types of data. Firstly, the news on interreligious dialogue in Berita Harian, an online Malay newspaper. Secondly, the answers given by four sociolinguists in their interviews covering questions on the needs and the process of the intellectualisation of the Malay language. The intellectualisation of the Malay language refers to the ability of the language to express intellectually the religious messages of all religions in Malaysia, which can be done through two different ways: linguistic and non-linguistic perspectives. The findings suggest that the intellectualisation of the Malay language as a religious language in Malaysian interreligious dialogue has strong potential for strengthening mutual understanding, respect and tolerance among the followers of different religions who participate in the dialogue.
论关于污水管线顶管施工中工作井的优化设计研究
Authors: 叶 高翔
Published: November 2019

随着城市的市政工程建设相关技术的高速发展，新设备、新材料、新工艺的大力度应用，使得城市的污水排放管道的顶管施工技术更加完善，形成了较为先进的施工工艺体系。当前，为了更好的发挥出该技术的积极作用，应充分的结合建筑工程项目的具体情况，充分的运用顶管技术的优点，有效的缩小工程项目施工挖掘施工的面积，使污水排放管道的建造安装平稳有序，同时，还可以合理的控制工程施工的成本。合理的实施不进行挖掘的管道安装技术，在充分的适应工程项目建造施工现场环境的情况下，根据管道安装方案的标准和需要，明智的选择安装建造的技术工序和机械设备。文章结合作者自身工作经验对污水管线顶管施工中工作井的优化设计进行分析，供参考。
安哥拉工程项目管理的几点思考
Authors: 熊 贵斌
Published: November 2019

目前中资建筑企业在国际项目上的参与度越来越高，实力较以往逐渐增强，工程业务不断扩大，对于中资企业的海外工程经验要求越来越高，必须重视海外项目管理中存在的问题。文章依据在非洲安哥拉工程建设工程中的一些实践经验，对工程项目管理从图纸设计方面、施工管理和工程结算等方面进行了简要探讨。
岩溶地区岩土工程勘查钻探技术的研究
Authors: 韩 军飞
Published: November 2019

在岩溶地区开展工程施工工作的时候，施工人员需要结合各方面因素，制定有效的施工计划，对工程施工质量和安全加以保证。工程勘察工作在岩溶地区工程建造工作中的所用是十分巨大的，勘察工作的目的就是从多个不同的角度对地质情况加以分析，为工程施工方案的制定提供参考。一般情况下，工程勘察钻探技术的水平与工程勘察结果的准确性存在一定的关联，所以需要工作人员加以重点关注。
探析道路与桥梁施工建设管理的技术要点
Authors: 张 佳佳 , 朱 礼磊
Published: November 2019

文章以道路桥梁工程项目的施工建设管理工作为研究对象，对其中的技术要点内容进行分析。在介绍并说明道桥工程特征的同时，从施工接缝、路床整修、排水系统、混凝土裂缝、人员技能管理这五个方面，详细论述具体的技术研点管理策略，为相关路桥工程的实践管理工作提供参考材料。
关于岩土地基的桩基检测问题探究
Authors: 荀 春生
Published: November 2019

随着社会主义市场经济的飞速发展，建筑事业也处于蓬勃发展的阶段，如今越来越多的建筑工程项目出现在大众的眼球，桩基检测技术也被广泛应用于各个建筑工程项目中。但在桩基检测的过程中还存在着一些不可估计的影响因素，因此，对桩基检测中存在的问题要进行认真分析，并采取有效的措施进行解决，这对于提高桩基检测相关工程的质量具有十分重要的现实意义。
Biochemical changes in Holotrichia repetita Sharp (Coleoptera: Melolonthidae) and Galleria mellonella L. (Lepidoptera: Pyralidae) due to the biopesticide Steinernema sp.
Authors: Bharathi N. Santhana , Deepa A. , Chithra P. , Aasha A. , Sujatha K.
Published: November 2019

In the present study, Steinernema- sp. were isolated from Tirupur soil sample and tested for its antagonistic potential against larvae of Galleria mellonella and Holotrichia repetita in laboratory condition. 100 per cent mortality was observed after 24 and 48 hours for G. mellonella and repetita respectively. Further biochemical estimations viz., protein, carbohydrates and lipids were carried out after 24 and 48 h of application. The results showed that there was a significant decrease in all biochemical parameters of parasitized larvae compared to control.  Steinernema sp. can be incorporated in IPM program for the control of G. mellonella and H. repetita.
Islam and Science. Tensions in Contemporary Epistemology
Authors: HEDIN CHRISTER
Published: November 2019

No abstract available
Religion, World Views and Gender Ideology
Authors: HELVE HELENA
Published: November 2019

No abstract available
The Rites of Passage Revisited: New Look at van Gennep's Theory of the Ritual Process and Its Application in the Study of Finnish-Karelian Wedding Rituals
Authors: ANTTONEN PERTTI J.
Published: November 2019

No abstract available
Interpreting Ethnic Categories Denoting 'Sacred' in a Finnish and an Ob-Ugrian Context
Authors: ANTTONEN VEIKKO
Published: November 2019

No abstract available
The IAHR regional conference on the study of religions in Africa at the University of Zimbabwe
Authors: GEERTZ ARMIN W.
Published: November 2019

No abstract available
Human Rights, Human Dignity and Islam
Authors: WAARDENBURG JACQUES
Published: November 2019

No abstract available
Pelatihan Untuk Pengajuan Pembiayaan Mudharabah Perbankan Syariah Sebagai Peningkatan Kinerja UMKM
Authors: Rizal Mohammad , Mustapita Arini Fitria , Kartika Sari Arista Fauzi
Published: November 2019

Financial management is one of the main aspects for the progress of a company. Accounting is a process or way of producing financial information that can be used to make a decision for its users. Implementation methods of Community Service activities is carried out using presentation methods, tutorial systems, and mentoring. The results of the training and mentoring activities for making Islamic banking mudharabah financing proposal aimed at residents of Malang City Kasin Village who are also perpetrators or owners of MSMEs, have been evaluated based on the response and the results of the practices carried out by the participants and assistance for 3 days. This evaluation of community service activities was carried out through a questionnaire and the results of feedback on questions in the questionnaire relating to training and mentoring materials for making bank credit proposal and the enthusiasm of the participants in each question and answer session. The level of understanding of the participants in understanding the material that has been delivered is grouped on a scale of 71% -80.99%, then the community service activities are declared "quite good" and there are 3 mudharabah financing proposals available from the results of mentoring activities
Insulin Resistance and Vitamin D Deficiency in Patients With Chronic Kidney Disease Stage 2-3
Authors: ŠTEFÍKOVÁ K. , SPUSTOVÁ V. , KRIVOŠÍKOVÁ Z. , OKŠA A. , GAZDÍKOVÁ K. , FEDELEŠOVÁ V. , DZÚRIK R.
Published: November 2019

Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range (≥30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH)2D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.
Association of eNOS Gene Polymorphisms T-786C and G894T With Blood Pressure Variability in Man
Authors: JÍRA M. , ZÁVODNÁ E. , HONZÍKOVÁ N. , NOVÁKOVÁ Z. , VAŠKŮ A. , IZAKOVIČOVÁ HOLLÁ L. , FIŠER B.
Published: November 2019

The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) T-786C and G894T in the gene encoding eNOS with blood pressure variability (BPV) in man. Blood pressure was recorded beat-to-beat at rest three times in periods of one week (5 min, Finapres, breathing at 0.33 Hz) in 152 subjects (19-24 years). Systolic (SBPV0.1r/SBPV0.1a) and diastolic (DBPV0.1r/DBPV0.1a) blood pressure variabilities in relative (r.u.) and absolute (mmHg2/Hz) units were determined by the spectral method as spectral power at the frequency of 0.1 Hz. Genotypes of both polymorphisms were detected using polymerase chain reaction and restriction analysis using enzymes Msp I and Ban II. Significant differences were observed in BPV among genotypes of T-786C SNP (p<0.05; Kruskal-Wallis), and among haplotypes of both SNPs (p<0.05; Kruskal-Wallis) as well. In T-786C SNP, carriers of less frequent allele (CC homozygotes and TC heterozygotes) showed significantly greater SBPV0.1r and SBPV0.1a compared to TT homozygotes (Mann-Whitney; p<0.05). The G894T variant showed no significant differences, but, both SNPs were in linkage disequilibrium (D’=0.37; p<0.01). Carriers of haplotype CT/CT (CC homozygotes of -786C/T and TT homozygotes of G894T) displayed significantly greater SBPV0.1r, SBPV0.1a and DBPV0.1a compared to carriers of other haplotype combinations (Kruskal-Wallis; p=0.015, p=0.048, and p=0.026, respectively). In conclusion, the haplotype formed by less frequent alleles of both eNOS variants was associated with increased systolic and diastolic BPV in this study.
Body Mass Index Change in Females After Short-Time Life Style Intervention Is Not Dependent on the FTO Polymorphisms
Authors: DLOUHÁ D. , SUCHÁNEK P. , LÁNSKÁ V. , HUBÁČEK J. A.
Published: November 2019

Variants within the FTO gene are important determinants of body mass index (BMI), but their role in determination of BMI changes after combined dietary/physical activity intervention is unclear. We have analyzed 107 unrelated overweight non-diabetic Czech females (BMI over 27.5 kg/m2, age 49.2±12.3 years). FTO variants rs17817449 (first intron) and rs17818902 (third intron) were genotyped. The life style modification program (10 weeks) consisted of an age-matched reduction of energy intake and exercise program (aerobic exercise 4 times a week, 60 min each). The mean BMI before intervention was 32.8±4.2 kg/m2 and the mean achieved weight loss was 4.8±3.5 kg (5.3±3.5 %, max. –15.5 kg, min. +2.0 kg, p<0.01). No significant association between BMI decrease and FTO variants was found. Also waist-to-hip ratio, body composition (body fat, water, active tissue), lipid parameters (total, LDL and HDL cholesterol, triglycerides) glucose and hsCRP changes were independent on FTO variants. FTO variants rs17817449 and rs17818902 are not associated with BMI changes after combined short time dietary/physical activity intervention in overweight females.
The variability of
multi-drug resistance ABCB1 gene in the Roma population from Croatia
Authors: Zajc Petranovic Matea , Tomas Zeljka , Skaric-Juric Tatjana , Smolej Narancic Nina , Janicijevic Branka , Stojanovic Markovic Anita , Pericic Salihovic Marijana
Published: November 2019

When overexpressed, a large transmembrane P-glycoprotein, the product of the ABCB1 gene, is a notable
impediment to brain-targeted therapies (like antiepileptics) and
chemotherapies. Some of the genetic biomarkers with evidence of multi-drug
resistance in ABCB1 ― rs1045642, rs1128503, and rs3213619 ― were analyzed in
440 subjects, members of three socio-culturally different Roma (Gypsy) groups
of Croatia.

Minor allele frequencies
(MAFs) of rs1045642 and rs1128503 were the highest in the Balkan Roma (63.6%
and 69.4%, respectively) when compared to the Baranja (52.3% and 62.5%) and the
Međimurje Roma (48.8% and 54.5%) (p=0.0005 and p=0.0011, respectively).
rs3213619 was monomorphic in the Međimurje group, while its MAFs in other two
Roma groups were very low (<1.9%). The distribution of five detected
haplotypes (four in the Međimurje group) significantly differed between the
Roma subpopulations (p<0.0001), just like the frequencies of diplotypes
(p=0.0008). At a global scale, the positive relationship between genetic and
geographic distances between the 21 investigated populations indicates
isolation by spatial distance. However, this is not true for the relationship
between Roma and other populations due to their population history.

The analyzed ABCB1 loci indicate genetic
distinctiveness of the Roma population.
Length heteroplasmy in the predominate mitochondrial DNA haplogroups in the Croatian population
Authors: Barbaric Lucija , Lipovac Korana , Sukser Viktorija , Rozic Sara , Korolija Marina
Published: November 2019

Mitochondrial control region represents the most
variable segment of the mitochondrial genome. The frequency and pattern of
heteroplasmy has been described in several studies; however, none of the
reports documented the Croatian population. In the present study, we screened
the control region (1122 bp) of 95 individuals belonging to two predominant
mitochondrial phylogenetic branches in the Croatian population, haplogroups H
and U. Length heteroplasmy occurred in polycytosine (poly-C) tracts within
three hypervariable segments of the control region with the following
frequencies: HVSI - 26.3%, HVSII - 52.6%
and HVSIII - 7.4%. Furthermore, the association between certain polymorphisms
in HVSI and length heteroplasmy was investigated. Our results indicate that
only polymorphisms located in the poly-C tract are associated with HVSI length
heteroplasmy. The T to C transition at np 16189 is significantly associated
with the occurrence of length heteroplasmy (p<0.0001). This effect was even
stronger if the C insertion was present in the position 16193. The data support
the hypothesis that an uninterrupted poly-C tract of more than eight cytosines
leads to length heteroplasmy. Length heteroplasmy associated with the T to C
substitution in np 16189 was predominantly found in haplogroup U.
Hereditary hemochromatosis
gene mutations in patients with myocardial infarction
Authors: Skrlec Ivana , Steiner Robert , Wagner Jasenka , Florijancic Mirela
Published: November 2019

Hereditary
hemochromatosis (HH) is a disorder of iron accumulation in tissues, which is
related to coronary heart diseases. Free radicals and reactive oxygen species,
created because of iron deposition, promote oxidation of LDL cholesterol and
could lead to the development of atherosclerosis. Studies have shown that HFE gene mutation carriers might be at
higher risk of developing cardiovascular diseases compared with non-carriers. This study aimed to determine
the frequency of HFE gene mutations
in patients with myocardial infarction compared to a healthy group in eastern
Slavonia. A retrospective case-control
study was carried out on a population of 400 participants. In the first group
there were 200 patients (114 males and 86 females) with myocardial infarction.
The second group consisted of 200 controls (103 males and 97 females) without a
history of cardiovascular diseases. All patients were genotyped
for the three most common mutations of the HH in the HFE gene: C282Y, H63D, and
S65C, by real-time PCR. The difference in the frequency of carriers of these
mutations between the patients and the controls was not significant (C282Y: 4.5
vs. 8.1%; H63D: 19 vs. 24.5%; S65C: 3.5 versus 4%), and neither was the
frequency and distribution of possible HFE
gene genotypes and compound heterozygotes. There were no statistically
significant associations of cardiovascular risk factors and HFE gene mutations in patients with
myocardial infarction. In this study, no association was found between the
HFE gene mutation for HH and
myocardial infarction in the population of eastern Slavonia.
Resistance of human
immunodeficiency virus type 1 to integrase strand transfer inhibitors in Croatia
Authors: Planinic Ana , Oroz Maja , Begovac Josip , Zidovec Lepej Snjezana
Published: November 2019

Integrase strand transfer
inhibitors (INSTIs) are the latest class of antiretroviral drugs that prevent
the integration of proviral DNA into the host genome. The aim of this study was
to describe, for the first time, INSTI resistance mutations observed in
Croatian HIV-infected patients. Methods: The study was
conducted between March 2016 and September 2018 and included 4 previously untreated
patients (antiretroviral, ARV-naive) as well as 18 unsuccessfully treated
HIV-infected patients (ARV-experienced) that have been tested for INSTI
resistance. The genetic data on INSTI resistance was obtained by
population-based sequencing of the integrase gene. Resistance analysis to other
classes of antiretroviral drugs has been performed in some patients by
sequencing the protease gene and a part of the reverse transcriptase HIV-1
gene.
Results: INSTI resistance
mutations were not found in ARV-naive patients. Mutations associated with
resistance to INSTIs have been observed in 5 of 18 (27.8%) patients failing
INSTI-based ARV regiment. Resistance to INSTIs in ARV-experienced patients was
attributed to major resistance mutations Q148R, N155H and E92Q that confer
resistance to two INSTIs (raltegravir and elvitegravir). Conclusions: The results of this study describe the
first 5 cases of ARV-experienced HIV-1 infected patients with clinically
significant resistance to INSTIs, and emphasize the need for continuous
surveillance of INSTI resistance in patients experiencing virological failure
to antiretroviral treatment in Croatia.
LINE-1 DNA methylation and
congenital heart defects in Down syndrome
Authors: Vranekovic Jadranka , Babic Bozovic Ivana , Zivkovic Maja , Stankovic Aleksandra , Brajenovic Milic Bojana
Published: November 2019

DNA methylation is a key epigenetic mechanism that plays a significant role in regulating gene activity during cardiac development. Congenital heart defects (CHD) are one of the most common abnormalities occurring in 40% -60% of cases with Down syndrome (DS). The main aim of this study
was to establish the association of long interspersed nucleotide element-1 (LINE-1) DNA methylation in children with DS and the presence of CHD. The LINE-1 DNA methylation was investigated in peripheral blood lymphocytes on a sample of 42 people with DS by quantification of LINE-1
methylation using the MethyLight method. No significant differences in global DNA methylation were found according to the presence of CHD (P=1.000), but values of LINE-1 DNA methylation were significantly influenced by gender (R2=19.1%; P=0.025). Significant probability of 19.1% was found in women with DS who had lower LINE-1 DNA methylation values than DS male . Gender was a statistically significant predictor of LINE-1 DNA methylation, although the difference was not statistically
significant, female subjects had lower LINE-1 DNA methylation values (P=0.068). Further research will clarify the role of lower LINE-1 DNA methylation in the formation of CHD among DS females.
Inhibition of PARP activity
does not affect the differentiation processes caused by retinoic acid in SH-SY5Y
cells
Authors: Horvat Luka , Grubar Martina , Madunic Josip , Antica Mariastefania , Matulic Maja
Published: November 2019

Differentiation is a complex process by which cells become specialized in their physiological functions. As this process is followed by a decrease in proliferation ability, the induction of differentiation could be an ideal cancer treatment. We
analyzed the effects of a common differentiation agent, retinoic acid, on
neuroblastoma SH-SY5Y cells under the conditions of poly(ADP-ribose) polymerase
(PARP) inhibition. Namely, PARP1 can be indirectly involved in processes of
chromatin remodelling, so the aim was to investigate whether its inhibition can
influence the process of differentiation. Cells differentiated after retinoic
acid treatment into neural cells, with neurite outgrowth, proliferation arrest
and induction of tissue plasminogen activator. PARP inhibition did not
influence the process of differentiation. Analysis of gene expression revealed
the involvement of several signaling pathways in RA-dependent differentiation.
Beside TGFβ and Notch pathways, master transcription factors directing
epithelial-mesenchymal transition were shown to also take part in the differentiation process.
In search of Robert Bruce, part III: medieval royal burial at Dunfermline and the tomb investigations of 1818–19
Authors: MacGregor Martin , Wilkinson Caroline
Published: November 2019

This article challenges two orthodoxies concerning Dunfermline's medieval church and abbey. It argues that David I and Malcolm IV were buried not with Robert Bruce, his queen, and Alexander III, but with Queen Margaret (died 1093), her husband, three of David's brothers, and Alexander III's first wife, as the earliest royal burial cluster. This argument dovetails with a reappraisal of the evolution of the medieval abbey. It is concluded that when dedicated in 1150, David's abbey was largely coextensive with his mother's church, only achieving cruciform status by 1180 and Queen Margaret's first translation. Reassigning David I and Malcom IV to another burial cluster strengthens the case for identifying the incumbent of the tomb discovered and excavated at Dunfermline in 1818–19 as Robert Bruce, as also argued for in the two other articles in this series.
A, B and (not) Seeing: Animals and Other Ironies in Alphabet Books
Authors: Ford Jennifer
Published: November 2019

For generations, alphabet books have been widely used by parents, librarians and teachers as early literacy tools for young children. Through images, word play and the interactions between word and image, alphabet books have the effect of introducing preliterate young children to the names, images, symbols and concepts regarding animals, what Matthew Calarco has called ‘symbolic mechanisms’ of animals—names, images, concepts, cultural associations of animals—yet they can also be deconstructive of those same mechanisms. Derrida's insights into the contradictory logic of the supplement and parergon as well as the ‘destabilising synergies of word and image’ offer deconstructive readings of alphabet books for adult and child readers. Recognising what Derrida calls the ‘childlike’ in texts such as alphabet books creates unique polymorphous spaces for the further interrogation of notions of animals.
The Case of The Case of Peter Pan or the Impossibility of Children's Fiction: Deconstruction, Psychoanalysis, Childhood, Animality
Authors: Lesnik-Oberstein Karín
Published: November 2019

This article argues a different understanding to that in children's literature studies more widely of the implications of the work of Jacqueline Rose in The Case of Peter Pan or: The Impossibility of Children's Fiction (1984) for thinking about childhood, animality and children's literature and links these implications to the similar implications of Jacques Derrida's thinking about the child and animality. In both cases, the child and the animal are seen not as psycho-biological entities nor as products of social constructivism nor as categories that must be seen as inclusive of variety, but as memories, where memory is understood in the psychoanalytic sense as a present production of a past, including ‘observation’ as remembered. The implications of the arguments are demonstrated in relation to readings of Jessica Love's award-winning picture book Julián is a Mermaid (2018) as well as several reviews of the text in relation specifically to ideas of (trans) sexuality, gender, childhood, ethnicity and mermaids. Key here is what is understood to be the shared interest of psychoanalysis and deconstructive thinking in not stabilising definitions but instead in reading them as shifting in perspective.
JUSTIFYING OF VARIANTS AND CONSTRUCTIVE PARAMETERS OF SYSTEM OF THIN ORE DEPOSIT MINING
Authors: Shchukin Sergey , Konurin Anton , Neverov Sergey
Published: November 2019

At present time mining of thin steep and sloping ore deposit is specified by significant lowering of extraction horizon – 700-1100m and by rise of different protective pillar parameters, as a result, losses of mineral raw materials are increased and entire efficiency of ore deposit mining is reduced. Therefore, issues of searching and development of mining systems and scientific approaches in justifying of safe parameters of geo-technologies, allowing to minimize geotechnical hazards, providing required quality of mined materials in dependence of geological and geo-mechanical conditions, become more important.
Objective of study is determining of safe parameters of geotechnologies with open mined space during mining of thin ore deposits in conditions of Irtyshsky polymetallic ore mine.
Main methods of studies are technological design and mathematical (numerical) simulation of stress-strain behavior and stability of rock at constructive elements of underground geotechnologies.
Room and pillar parameters are established by carried out calculations for mining systems with open mined space, providing safety of mining at deposit locations with steep and slopping ore dip.
Using 3-dimensional mathematical simulation during studies of typical geological and geo-mechanical condition of the functioning mine significantly extends knowledge and approaches in solution of rather difficult problems. It shows high reliability and correctness of results for concrete unique mine-technical situations.
FACTORS OF CONSUMPTION OF RENEWABLE ENERGY SOURCES AT THE INTERNATIONAL LEVEL: DEVELOPMENT OF THE EVALUATION MODEL
Authors: Kozhevin Vladislav , Eder Leonty
Published: November 2019

Based on the use of panel data, the work establishes the relationship between the development of renewable energy sources and (1) the price of fossil energy, (2) the supply of oil and gas consumption through its own production, (3) the factor of the country's technological development and (4) the influence of non-competitive political institutions. The period of high prices for fossil energy (1999-2014) became the catalyst for changes in the structure of the energy balance, especially in Europe, with an increase in the production of renewable energy. However, the fall in prices in 2014 - to the present has led to stagnation in the production of renewable energy with a rapid increase in the use of fossil fuels. In the context of this work, the significance of the factors under study on the consumption of renewable energy sources is proved.
FEATURES OF CAPITAL STRUCTURE OF OIL AND GAS COMPANIES
Authors: Gevorgyan Alla , Mishenin Mikhail
Published: November 2019

In this paper the features of the capital structure of oil and gas companies are considered, a comparative analysis of own and borrowed capital of oil and gas companies structures is carried out.
STRUCTURAL CHANGES IN THE PRODUCTION OF NATURAL GAS OF THE SIBERIAN FEDERAL DISTRICT
Authors: Kazanenkov Valery
Published: November 2019

The article discusses the oil and gas complex of the Siberian Federal District at the stage of the need to transition to a new paradigm of development of the oil and gas complex of Russia. Over the past decade, the Siberian Federal District has been the most dynamic region of Russia in the development of the last large and unique hydrocarbon fields, the development of the mining and transport infrastructure. The restructuring of the organizational and legislative system of subsoil use, the transition from the extensive to the intensive development model, the creation of new technologies and equipment, and the ensuring of the integrated development of the subsoil are necessary.
ANALYSIS OF ECOLOGICAL BALANCE IN THE ARCTIC REGIONS OF OIL PRODUCTION ON THE EXAMPLE OF YANAO
Authors: Yurkevich Nataliya , Filimonova Irina
Published: November 2019

The trends of environmental management at oil and gas enterprises, the main geo-environmental problems associated with oil and gas production in the Arctic territories are considered on the example of the Yamalo-Nenets Autonomous District, the prospects for using environmental-economic modeling for scientific justification for improving the development of the region’s oil and gas sector.
Solving Integer Linear Programs by Exploiting Variable-Constraint Interactions: A Survey
Authors: Ganian Robert , Ordyniak Sebastian
Published: November 2019

Integer Linear Programming (ILP) is among the most successful and general paradigms for solving computationally intractable optimization problems in computer science. ILP is NP-complete, and until recently we have lacked a systematic study of the complexity of ILP through the lens of variable-constraint interactions. This changed drastically in recent years thanks to a series of results that together lay out a detailed complexity landscape for the problem centered around the structure of graphical representations of instances. The aim of this survey is to summarize these recent developments, put them into context and a unified format, and make them more approachable for experts from many diverse backgrounds.
Forgotten, But Not Lost—Alloparental Behavior and Pup–Adult Interactions in Companion Dogs
Authors: Pongrácz Péter , Sztruhala Sára S.
Published: November 2019

Socialization with humans is known to be a pivotal factor in the development of appropriate adult dog behavior, but the role and extent of dog–dog interactions in the first two months of life is rarely studied. Although various forms of alloparental behaviors are described in the case of wild-living canids, the social network of companion dogs around home-raised puppies is almost unknown. An international online survey of companion dog breeders was conducted, asking about the interactions of other dogs in the household with the puppies and the pups’ mother. Based on the observations of these breeders, our study showed an intricate network of interactions among adult dogs and puppies below the age of weaning. Alloparental behaviors (including suckling and feeding by regurgitation) were reportedly common. Independent of their sex, other household dogs mostly behaved in an amicable way with the puppies, and in the case of unseparated housing, the puppies reacted with lower fear to the barks of the others. Parousness, sexual status, and age of the adult dogs had an association with how interested the dogs were in interacting with the puppies, and also with how the mother reacted to the other dogs. Our study highlights the possible importance of dog–dog interactions during the early life of puppies in forming stable and low-stress interactions with other dogs later in life.
Use of Medicinal Mushrooms in Layer Ration
Authors: Mahfuz Shad , Piao Xiangshu
Published: November 2019

Application of different medicinal mushrooms intended to enhance production performance and health status has created an importance demand in poultry production. One goal of using medicinal mushrooms is to get rid of antibiotics in poultry feed without affecting the optimum performance. Increasing concerns about this issue have led to more attention on antibiotic substitutes and a significant demand for them for organic egg production. Thus, supplementation with medicinal mushrooms is a new concept for research in layer production, however, there is still a great deal of confusion about inclusion levels and the mode of action of medicinal mushrooms on production performance and health status in laying hens. Taking this into account, this review outlines the experimental uses of medicinal fungi on the growth performance, laying performance, egg quality, and health status of layer birds based on previous findings to date. Finally, we highlight that supplementation with medicinal fungi can play a role on the immunity, health, and production performance in laying hens.
Parasite Load and Site-Specific Parasite Pressure as Determinants of Immune Indices in Two Sympatric Rodent Species
Authors: Hofmeester Tim R. , Bügel Esther J. , Hendrikx Bob , Maas Miriam , Franssen Frits F. J. , Sprong Hein , Matson Kevin D.
Published: November 2019

Wildlife is exposed to parasites from the environment. This parasite pressure, which differs among areas, likely shapes the immunological strategies of animals. Individuals differ in the number of parasites they encounter and host, and this parasite load also influences the immune system. The relative impact of parasite pressure vs. parasite load on different host species, particularly those implicated as important reservoirs of zoonotic pathogens, is poorly understood. We captured bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus) at four sites in the Netherlands. We sampled sub-adult males to quantify their immune function, infestation load for ecto- and gastrointestinal parasites, and infection status for vector-borne microparasites. We then used regression trees to test if variation in immune indices could be explained by among-site differences (parasite pressure), among-individual differences in infestation intensity and infection status (parasite load), or other intrinsic factors. Regression trees revealed splits among sites for haptoglobin, hemagglutination, and body-mass corrected spleen size. We also found splits based on infection/infestation for haptoglobin, hemolysis, and neutrophil to lymphocyte ratio. Furthermore, we found a split between species for hemolysis and splits based on body mass for haptoglobin, hemagglutination, hematocrit, and body-mass corrected spleen size. Our results suggest that both parasite pressure and parasite load influence the immune system of wild rodents. Additional studies linking disease ecology and ecological immunology are needed to understand better the complexities of host–parasite interactions and how these interactions shape zoonotic disease risk.
Effects of Outdoor Access and Indoor Stocking Density on Behaviour and Stress in Broilers in the Subhumid Tropics
Authors: Sanchez-Casanova Rubi , Sarmiento-Franco Luis , Segura-Correa Jose , Phillips Clive J. C.
Published: November 2019

Studies investigating the welfare of commercial-line broiler chickens raised in houses with outdoor access in the tropics are scarce, and none have investigated whether responses vary according to indoor conditions. Hence, we assessed the effects of providing outdoor access at two indoor stocking densities on broiler chickens’ growth, behaviour, stress responses and immunity in a tropical region of Mexico. One hundred and sixty chickens were assigned to one of four treatments in a factorial design: with or without outdoor access and low or high stocking density indoors. Ad libitum sampling was used to build a purpose-designed ethogram. Scan sampling was used to record the number of birds engaged in each activity of this ethogram, both indoors and outdoors. Heterophil/lymphocyte (H/L) ratio and serum corticosterone levels were tested in weeks four and six of age. When the birds were 42 days old, they were slaughtered, and the bursa and spleen harvested and weighed. In an interaction between stocking density and outdoor access, birds at the high stocking density with no outdoor pens spent the least time walking and preening and more time lying (p < 0.05). Birds given outdoor access foraged more, but only at indoor low stocking densities (p < 0.05). Outdoor access reduced heterophil/lymphocyte ratio, indicating reduced stressor response. Birds with low stocking density indoors and outdoor access appeared more responsive to stressors, with elevated corticosterone and reduced spleen and bursa weights (p < 0.05). There were welfare benefits of outdoor access, principally in terms of increased activity, which were reflected in slower growth in the birds with outdoor access.