bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical role of brain natriuretic peptide in predicting the development of severe pre-eclampsia
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Timokhina E.V. , Ignatko I.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Grigoryan I.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Fedyunina I.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bogomazova I.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pesegova S.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Melek M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Askerova S.F. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Cherkashina A.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: January 2025

Objective. To study the serum levels of brain natriuretic peptide (BNP) in women with uncomplicated pregnancies and in women with pre-eclampsia (PE) of varying severity and to determine the significance of BNP as a possible marker of cardiac dysfunction and maternal hemodynamic maladaptation.
Patients and methods. This prospective study included 107 pregnant women between 22 and 40 weeks of gestation. The study group consisted of 77 patients with a confirmed diagnosis of PE. To assess the role of BNP in different severities of PE, two patient subgroups were identified: patients with moderate PE – 44 (57.1%) and patients with severe PE – 33 (42.9%). The control group included 30 patients with uncomplicated pregnancies. Serum BNP levels were determined by electrochemiluminescence immunoassay.
Results. Pregnant women with PE were found to have significantly higher serum BNP levels than healthy controls (79.5 pg/mL, 398.5 pg/mL and 36.0 pg/mL, respectively). Patients with severe PE had significantly higher BNP levels than patients with moderate PE (398.5 and 79.5 pg/mL, respectively).
Conclusion. Serum BNP levels correlate with the severity of PE. Further study of the role of BNP in pregnant women with earlyand late-onset PE in correlation with fetoplacental indicators as a prognostic marker of the development and severity of this life-threatening pregnancy complication is possible.
Key words: brain natriuretic peptide, development of severe pre-eclampsia, pre-eclampsia, BNP
Results of the Russian observational study EFFECTICARE on transdermal contraception
Authors:   D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, Saint Petersburg, Russian Federation, Yarmolinskaya M.I. ,   I.I.Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation, Karakhalis L.Yu. ,   Kuban State University, Krasnodar, Russian Federation, Cherkashina S.A. ,   D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, Saint Petersburg, Russian Federation
Published: January 2025

Modern contraceptive methods provide effective prevention of abortion and contribute significantly to women’s reproductive health. Combined oral contraceptives are the most popular form of reversible hormonal contraception. However, they have several disadvantages, which necessitates the search for new, more convenient and controllable methods. One such method is the transdermal therapeutic system.
Objective. To study the short- and long-term risks of using a transdermal contraceptive patch (norelgestromin 6 mg + ethinyl estradiol 0.6 mg) in reproductive-aged women who have a need for birth control.
Patients and methods. An open-label, multi-center, observational study EFFECTICARE on the application of transdermal contraceptive patch containing norelgestromin 6 mg and ethinyl estradiol 0.6 mg was conducted. The study included 1624 patients who were divided into two age subgroups: 18–25 years and 26–37 years, as it is known that younger women are mostly primary users of contraception, with less experience and lower adherence.
Results. The use of transdermal contraceptive patch (norelgestromin 6 mg + ethinyl estradiol 0.6 mg) had high contraceptive efficacy, good cycle control, reduction in the volume and duration of withdrawal bleeding, as well as manifestations and frequency of dysmenorrhea and dyspareunia, asthenic syndrome; it did not affect body weight. No adverse effect on liver function parameters was noted. Undesirable reactions were rare and did not lead to contraceptive discontinuation. The level of satisfaction with transdermal contraception after 6 months was 95%.
Conclusion. The transdermal therapeutic system is an effective and convenient method of hormonal contraception, allowing women to reduce the number of unintended pregnancies and abortions, preserve reproductive health and high quality of life.
Key words: contraception, contraceptive patch, transdermal therapeutic system
REPRESENTASI “KOMDIS” DALAM ALTERNATE UNIVERSE OLEH FANDOM NCTZEN SEBAGAI PROSES HIPERREALITAS
Authors: Pitaloka Pramesti Ayu , Mundayat Aris Arif
Published: January 2025

Alternate Universe (AU) is a form of fan fiction that talks about the main character (idol) in a situation and life that is made different from their original life. Twitter is one of the media used to write AUs. The majority of AUs on Twitter are presented in the form of threads containing fake chats, narratives, pictures or photos, and even videos. The blurred boundaries of reality that exist in AUs have several impacts, such as the construction of the reader's mind that their idols have the characteristics shown in the story. Many writers create role-player accounts of fictional characters to accommodate readers' imaginations. Thus, many readers cannot distinguish between the original and simulated realities. One of the most popular AUs is “Komdis” which will be the focus of this research. The researcher will examine in more depth how the relationship between AU “Komdis” in the hyperreality process and how readers represent it in social media. This research uses a qualitative method with an autoethnographic approach where the researcher is also the author of AU “Komdis”. The theory used to analyze the data findings in this research is Jean Baudrillard's hyperreality theory and Stuart Hall's representation theory. The results show that there is a double simulation where the AU itself is a simulation. Then, the readers who are simulated by “Komdis” simulate it again on social media. 

 
Analysis of Print Speed Variations Effect and Nozzle Temperature on the Tensile Strength of 3D Printed TPU-95A Products
Authors: Gulo Triadesman , Mardiyana Dani , Sumarno Dodi Iwan
Published: January 2025

This study aims to analyze the effect of print speed and nozzle temperature variations on the tensile strength of TPU-95A material printed using the fused deposition modeling (FDM) method. The varied parameters include print speeds (70, 80, and 90 mm/s) and nozzle temperatures (230 and 240 °C). Tensile test specimens were produced using an Ender-3 Pro 3D printer according to the JIS K6251-2017 standard and tested with a Shimadzu AGS-X 10kN tensile testing machine. The results showed that the combination of a 90 mm/s print speed and a 230 °C nozzle temperature yielded the highest tensile strength of 318.74 kgf/cm². Conversely, the lowest tensile strength of 212.20 kgf/cm² occurred at a 90 mm/s print speed and a 240 °C nozzle temperature due to thermal degradation of the material. This study highlights the importance of selecting optimal printing parameters to enhance the mechanical strength of 3D-printed products made from TPU-95A.
How can Physical Education teachers’ high directiveness impact students’ experiences of enjoyment and boredom?
Authors: Diloy-Peña Sergio , García-Cazorla Javier , Mayo-Rota Carlos , García-González Luis , Villafaña-Samper Zilia , Abós Ángel
Published: January 2025

Based on Self-Determination Theory, a recent theory in the educational context introduces an integrative and detailed circumplex model that categorizes teaching styles into eight (de)motivating approaches, depending on their level of directiveness and support or threat to students’ needs. However, the evidence so far on how high directiveness approaches (i.e., guiding, clarifying, demanding, domineering) is limited regarding its potential connection to various (mal)adaptive outcomes in Physical Education, given that Physical Education teachers can adopt different high directiveness approaches for optimal classroom management. The present study aims to examine the differential impact of high directiveness leadership: structuring style (i.e., guiding and clarifying) versus controlling style (i.e., demanding and domineering), on students’ affective outcomes (i.e., enjoyment and boredom). A convenience sample of 697 students (51% girls; Mage = 14.52; SD = 1.45), aged between 12 and 17 years, participated in this cross-sectional study. The results  show that enjoyment during Physical Education lessons was positively and significantly predicted by the guiding and clarifying approaches. In contrast, boredom was negatively and significantly predicted by the guiding approach, while the domineering approach positively and significantly predicted boredom. The results emphasized the importance of Physical Education teachers adopting structuring approaches (i.e., guiding and clarifying) and avoiding controlling approaches (i.e., demanding and domineering) to promote adaptive affective outcomes in students.
Dating Subhorizontal Ductile Fabric in the Feidong Complex via Zircon and Titanite U–Pb Geochronology: Insights into Middle Triassic Transpressional Deformation along the Southern Tan-Lu Fault Zone
Authors: Qiu Erkang , Zhang Yueqiao , Larson Kyle P.
Published: January 2025

The Triassic collision between the Yangtze and North China blocks resulted in the formation of ultrahigh-pressure metamorphic rocks along the Dabie-Sulu orogenic belt, the development of the Tan-Lu fault zone, and the establishment of a crustal-scale décollement within the Lower Yangtze foreland fold-thrust zone. The ductile fabrics exposed in the Zhangbaling–Feidong Complex of the southern Tan-Lu fault zone record the strain that accumulated during that collision. Herein, field observations and structural analysis of high-strain rocks (i.e. microstructures and quartz crystallographic preferred orientations) from the eastern Feidong Complex are combined with estimates of deformation P-T conditions to reveal that top-to-SSW subhorizontal, amphibolite-facies (600 and 700℃, 4.0–6.6 Kbar) ductile fabrics overprint the Paleo-Proterozoic Feidong Complex. U–Pb geochronology on zircon rims and syntectonic titanite indicates that the overprinting deformation occurred in the Middle Triassic (ca. 246–242 Ma). Reinterpretation of reflection seismic profiles across the Tan-Lu fault zone and Lower Yangtze foreland fold-and-thrust zone identifies a large, subhorizontal décollement beneath the sedimentary cover that appears to have influenced the formation of fold-thrust structures in the Lower Yangtze foreland. These new observations and geochronological results are consistent with a transpressional tectonic model wherein the Early-Middle Triassic northward indentation of the Yangtze block into the North China block drove deformation within the southern Tan-Lu fault zone.
El cómic digital como recurso para consolidar el aprendizaje en la educación secundaria obligatoria
Authors: Ontenient Lledó Ana Isabel
Published: January 2025

Currently, there are several digital applications that make it possible to create comics, which can enhance study in obligatory secondary education. Their use is an excellent contribution to the curriculum of different subjects by presenting the content through contextualised images and a more accessible language. This study will focus on the educational benefits of digital comics. Therefore, the main objective is to elaborate an analysis that highlights digital comics as a tool that simplifies learning for students, based on a review of the existing literature. In recent years, the virtual comic has begun to be used frequently in obligatory secondary education thanks to various initiatives that promote its use, such as training courses for teachers and the dissemination of educational comics through social networks. Among the advantages of digital comics over classic comics is their interactivity, which allows students to view animations or listen to sounds, show or hide elements, or even choose the outcome of the story. These qualities make the virtual comic a more interesting educational resource, which also facilitates learning by teaching content in a more entertaining and visual way.
Más allá del telediario…El contenido informativo en las prácticas mediáticas de los y las jóvenes
Authors: Goirizelaia Maialen , Arana Edorta , Narbaiza Bea
Published: January 2025

The young students of the autonomous communities of the Basque Country and Navarre make extensive use of the media, especially those online and, in particular, social networks. Informative content occupies a relevant place in their daily media diet. An anonymous study carried out among more than 1,500 young students between the ages of 11 and 23, shows their tastes and preferences when it comes to get informed. The research yields important data on the weight reached by social networks as sources of information, ahead of traditional television. This study makes a comparative analysis of the information sources used by secondary school students and those enrolled in university and, in the final part, focuses on the monitoring of the interest showed by these young students on the Ukraine War.
Lineamiento - Asignación de bonificación a la producción científica ﻿
Authors:   Universidad Científica del Sur
Published: January 2025

Lineamiento – Asignación de bonificación a la producción científica . Versión 6.0 (2025). Vigente.
Integration of Historically Marginalized students’ and teachers’ identities, languages, and lived worlds in urban middle school science classrooms
Authors: Sealy Martinique , Lee-Bae Christine , Hogan Erin
Published: January 2025

This qualitative case study explored the incorporation of students' funds of knowledge (FoK) by six middle school science teachers in diverse urban classrooms. Drawing from asset-based and culturally inclusive pedagogies, our study is based on the premise that students' diverse identities, languages, and lived experiences (i.e. FoK) are valuable resources for their learning. This study aimed to achieve three primary objectives: 1) explore how teachers recognized the diverse FoK of marginalized students, 2) examine the relationship between teachers' FoK and students' FoK, and 3) investigate the extent to which teachers integrated students' FoK into their teaching methods. Our analysis revealed that teachers' individual FoK backgrounds uniquely shaped how they identified and incorporated their students' FoK into the classroom, shedding light on the diverse approaches employed by teachers in delivering culturally relevant instruction.
Selective electrosynthesis of 1,3-butadiene by tailoring the coverage of acetylene and water
Authors: Zhang Bin , Cheng Chuanqi , Wang Jiajun , Chen Fanpeng , Han Yanran , He Yichen , Zhao Bo-Hang
Published: January 2025

1,3-Butadiene (C4H6), the main raw material for producing important chemicals (nylon, synthetic resin, rubber), relies on petroleum cracking with intensive carbon emissions. The electrocatalytic dimeric hydrogenation of natural gas/coal-derived C2H2 to C4H6 provides a nonpetroleum pathway. However, C4H6, as a byproduct of C2H2 hydrogenation, is usually neglected because of its very low Faradaic efficiency. Here, we theoretically and experimentally report a mechanism comprising acetylene dimerization and subsequent hydrogenation. The first dimerization process can be accelerated under appropriate coverage of acetylene and water. A ligand-modifying strategy is subsequently proposed to regulate the wettability of Cu nanoarrays to enable suitable coverages. The optimized 1-dodecanethiol-modified Cu nanoarrays deliver a 65.3% C4H6 Faradaic efficiency at 100 mA cm−2. The C4H6 formation kinetics become sluggish at the two ends of the surface C2H2/H2O ratios, and moderate C2H2/H2O coverage accelerates the C‒C coupling process to promote C4H6 production. Moreover, life cycle assessment demonstrates its sustainability.
Factors Influencing the Integration of Technology of High School English Teachers in Indonesia: Analysis Structural Equation Modelling (SEM) and Partial Least Square (PLS)
Authors: Haryanto Eddy , Hendra Robi , Sembiring Dian Arisandy Eka Putra , Yusuf Muhammad , Sadikin Ali , Firdaus Rangga , Widana I Wayan
Published: January 2025

This study aims to present teachers’ understanding of TPACK (technology, pedagogy, and content knowledge) and how TPACK is manifested in use, and the research examines the concept of teachers’ technology integration (Tecint). In particular, the primary purpose of this study is to find out the factors that influence English teachers in technology integration in Jambi city, Indonesia. This study is a cross-sectional survey in which the data were collected at one point in time from a sample of 294 English teachers. This study reveals that perceived technology knowledge had a significant and positive effect. Perceived knowledge to integrate technology (PKforIT), perceived knowledge to integrate technology (PKforIT) significantly and positively influenced ICT pedagogical practice (ICTpedPra), ICT pedagogical practice (ICTpedPra) had a significant and positive effect on Teacher Knowledge (excluding technology) (TKexTEC), knowledge of technology perceptions (CAR), knowledge to integrate technology perceptions (PKforIT) had significant and positive influence on technology integration (TecInt) as well as significant and positive significant and positive effect on technology integration (TecInt), ICT pedagogical practices (ICTpedPra) significant and positive effect Technology integration (TecInt), teacher knowledge (excluding technology) (TKexTEC) had a positive and significant effect technology integration (TecInt), institutional support for ICT innovation and use (INStitSupport), technology integration (TecInt) significant effect and positive on motivation (MotVat) and motivation (MotVat) had a significant and positive effect on Work Engagement (WorkEgag) significantly and positively had a positive and significant impact on technology integration (TecInt). This finding shows that to integrate teachers must pay attention to teachers' understanding of technology, knowledge, and support from subsequent institutions. Job engagement is influenced by the work motivation of the English teacher.
Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2.
Authors: Menard Caroline , Paton Sam , Solano José , Cadoret Alice , Collignon Adeline , Binder Luisa , Richer Emanuelle , Coulombe-Rozon Francois , Dion-Albert Laurence , Dudek Katarzyna Anna , Consortium Signature , Lebel Manon
Published: January 2025

Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage of circulating inflammatory mediators in mood-regulating brain areas and establishment of depressive behaviors. Conversely, neurovascular adaptations favoring resilience to stress exposure and preventive strategies to promote them remain poorly understood. Here, we report that environmental enrichment dampens stress-induced loss of endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety- and depression-like behaviors in mice via an increase in fibroblast growth factor 2 (Fgf2). Coping with voluntary physical exercise also protects the BBB from stress deleterious effects by increasing Fgf2. This growth factor acts on endothelial cells by preventing Cldn5 loss, exacerbated inflammation, and social avoidance. Fgf2 is mostly expressed by glial cells and astrocyte-specific increase of Fgf2 expression dampens stress-induced social avoidance. Treatment of mouse and human endothelial cells with Fgf2 preceding an immune challenge with the proinflammatory cytokine tumor necrosis alpha (TNFα), known to be elevated after chronic stress and in depression, reduces BBB dysfunction, and altered cell signaling supporting its role in BBB protection. Circulating FGF2 level is linked with depression severity and symptomatology in humans supporting involvement of this growth factor in mood disorders and stress-induced BBB changes.
Nonlinear Transformation of Probabilities by Large Language Models
Authors: Hintze Arend , Bisht Charu , Schossau Jory , Hertwig Ralph
Published: January 2025

Large Language Models (LLMs) such as ChatGPT and Claude demonstrate impressive abilities to generate meaningful text and mimic human-like responses. While they undoubtedly can boost human performance, there is also the risk that uninstructed users rely on them for direct advice without critical distance. A case in point is advice on economic choice. Choice tasks often involve probabilistic outcomes. In these tasks, human choice has been demonstrated to systematically diverge from rational, that is, linear weighting of probabilities, and reveals an inverse S-shaped weighting pattern in description-based choice (i.e., overweighting of small probabilities and underweighting of large ones), and an S-shaped weighting pattern in experience-based choice. We investigate how LLMs' choices transform probabilities in simple economic tasks involving a sure outcome and a simple lottery with two probabilistic outcomes. LLMs' choices do most often not yield an inverse S-shaped probability weighting pattern; instead, they display distinct nonlinearity-in-probabilities. GPT-3.5 exhibited risk-seeking behavior, Claude 3.0 showed a strong recency bias, and GPT-4.0 underweighted small and overweighted large probabilities, resembling weighting patterns of decisions from experience rather than from description. These findings raise concerns about the quality of the advice users would receive on economic choice from LLMs, highlighting the necessity of critically using LLMs in decision-making contexts.
Evaluation of the sixth coding exon of IL12RB1 in patients afflicted by the non-healing form of cutaneous Leishmaniasis
Authors: Moafi Mohammad , Rezvan Hossein , Taleban Roya , Mansourian Marjan , Sokhanvari Fatemeh , Ansari Nazli , Sherkat Roya
Published: January 2025

Background and Objective: Cutaneous Leishmaniasis (CL) appears as a localized skin lesion, that is curable without any clinical intervention. However, Leishmania infection rarely manifests as non-healing lesions persisting for many years. The current study aimed to assess the sixth coding exon of IL12RB1 in the non-healing form of CL.
Materials and Methods: Leishmania infection was diagnosed through a direct smear. The sixth coding exon of the IL12RB1 was sequenced.
Results: No polymorphism was found in the sixth coding exon of the IL12RB1 gene
Conclusion: This study indicated that the sixth coding exon of IL12RB1 does not contribute to the non-healing form of cutaneous Leishmaniasis.
Digital Preservation of Microgestures in the Making Process of Indonesian Iconic Traditional Rattan Chair Using Immersive 360° Learning Videos and Photogrammetry
Authors: Junaidy Deny Willy , Oktanuryansyah Muhammad Nabil , Arisya Khalda Fadhilah , Mawali Linda , Dhani Muhammad , Mutiaz Intan Rizky , Suwardhi Deni
Published: January 2025

Although rattan artifacts have been extensively archived, few studies have focused on documenting the knowledge and craftsmanship of artisans who create traditional rattan chairs. These skills often rely on tacit knowledge, which is challenging to capture and transfer. This study aimed to preserve the creation process of iconic Cirebon rattan chairs—Papasan, Bahama, Kelek, Gentong, and Keong—crafted for over 50 years by leveraging digitization techniques. By combining 360° video technology with photogrammetric techniques, the study produced immersive learning materials that effectively captured artisans' subtle and often difficult-to-observe micro-gestures. The 360° video technology recorded these intricate gestures, while photogrammetry generated realistic three-dimensional visualizations of the furniture and tools used. Visual recall testing demonstrated that these immersive learning videos effectively teach delicate and nuanced techniques unique to rattan chair-making, such as using the chest, knees, armpits, soles, and toes. Furthermore, the methods and findings of this study highlight the potential of 360° video technology in preserving other crafts that involve complex and precise manual skills.
A Cas6 functions as an anti-CRISPR of type I-B CRISPR-Cas effector in Thermus thermophilus
Authors: Li Yingjun , Wei Junwei , Shao Yuan , Liang Yuqian , Bu Xuying , Zhou Wen , Liang Yun Xiang
Published: January 2025

Cas6 family ribonucleases can generate functional crRNAs in most type I and type III CRISPR-Cas systems. Most existing studies of Cas6 functions are mainly focused on nuclease activity in vitro and Cas6-processed product characterization in vivo. However, the biological functions of co-occurrence and cross-cleavage of various Cas6 proteins in a multi-CRISPR system host remain largely unexplored. In this study, we biochemically characterized the cross-cleavage of two Cas6 proteins in Thermus thermophilus HB27 and found for the first time that Cas6 could anchor the mature crRNA and interact with Cas5 subunit of type I-B system, revealing the functions of Cas6 to mediate the assembly of the type I Cascade complex. We further demonstrated that Cas6 of type III CRISPR-Cas system could be assembled into I-B Cascade complex, in turn significantly inhibiting the interference activity of type I-B system as an anti-CRISPR. Our findings provide an insight into the functional coupling and regulation mechanisms underlying multiple CRISPR-Cas systems, thereby offering valuable references for designing and controlling type I CRISPR-based gene editing tools precisely.
Effect of Seasonal Dynamics in Water Temperature and Electrical Conductivity on β- Carotene Biosynthesis in Green Spinach (Silver-beet) and Lettuce (Locarno) Leaves from Aquaponic Greenhouse
Authors: Ibrahim Labaran
Published: January 2025

The present study was conducted to determine the effects of seasonal dynamics in water temperature (WT) and electrical conductivity (EC) on β-Carotene biosynthesis in green spinach (GRSP) (Silver-beet) and green lettuce (GRLE) (Locarno) leaves from an aquaponic greenhouse. The WT and EC of the fish water tap (FWTP) and deep-water culture tank (DWCT) were assessed with a portable dissolved oxygen meter (Model: PDO-520, Taiwan) and a multi-parameter water quality meter (PHT-27, China), respectively. β-Carotene biosynthesis in GRSP and GRLE leaves was analyzed via HPLC-Shimadzu Prominence (Tokyo, Japan). This research was carried out for 4 consecutive seasons (winter, spring, autumn, and summer). The WT levels of the FWTP and DWCT components ranged from 12.12 ± 1.34–25.21 ± 0.95°C. The EC values of these 2 components ranged from 0.55 ± 0.05–0.65 ± 0.55 mS/cm. The WT and EC values were significantly (p < 0.05) different among the 4 seasons. Throughout the research period, the highest and lowest WT and EC levels were detected in the summer and winter periods, respectively. Furthermore, β-Carotene biosynthesis in the GRSP and GRLE leaves ranged from 3.63 ± 0.27–25.80 ± 6.67%. A significant (p < 0.05) difference in β-Carotene biosynthesis of the 2 leafy materials was recorded in the summer and autumn. However, no significant (p > 0.05) different was detected in the winter and spring. The highest level of β-Carotene biosynthesis was obtained in the summer. The results of the present study revealed that seasonal changes in WT and EC induced variations in β-Carotene biosynthesis in the studied vegetable materials. Hence, this work could be used to interpret better climate or growing conditions for sustainable food production.
Pharmacokinetics and Toxicity Study of a Single Intravenous Dose of Distilled Extract of Zanthoxylum piperitum in ICR Mice
Authors: Jang Ji Yong , Kim Jong Uk , Yang Gabsik , Lee Jun Ho , Yook Tae Han
Published: January 2025

This study aimed to investigate the pharmacokinetics and acute toxicity of a single intravenous dose of distilled Zanthoxylum piperitum (deZP) extract in ICR mice. The focus was on understanding the absorption, distribution, and elimination of Terpinen-4-ol, the major active component of deZP, as well as assessing its safety at the administered dose. ICR mice were administered a single intravenous dose of deZP (2.4 mg/kg), and plasma concentrations of Terpinen-4-ol were measured using LC-MS/MS at various time points. Pharmacokinetic parameters such as Cmax, Tmax, half-life, and clearance rate were calculated. In addition, clinical signs, mortality, and biochemical markers were monitored to evaluate acute toxicity. Terpinen-4-ol was rapidly absorbed, reaching a peak plasma concentration (Cmax) of 609.0 ng/mL within 0.083 hours (Tmax). It exhibited a short half-life of 0.168 hours and a high clearance rate of 194.1 L/h/kg. No mortality or significant clinical signs of toxicity were observed. Biochemical parameters, including liver and kidney function markers, remained within normal ranges, indicating that the administered dose was well-tolerated. The pharmacokinetic profile of deZP suggests rapid absorption and elimination of Terpinen-4-ol, while the toxicity assessment indicates good tolerability at the tested dose in ICR mice. These findings provide a foundation for further exploration of deZP's therapeutic potential.
Predicting current and future suitability for intermediate snail hosts of urogenital and intestinal schistosomiasis in a floodplain of Malawi
Authors: Nkolokosa Clinton , Chirombo James , Jones Christopher M. , Kambewa Eggrey Aisha , Tangena Julie-Anne Akiko , Stothard J. Russell
Published: January 2025

This paper presents the first species distribution models (SDMs) for intermediate snail hosts for urogenital and intestinal schistosomiasis in the Lower Shire Valley (LSV), Malawi. The SDMs are specific to the Bulinus africanus group and Biomphalaria pfeifferi. The former transmits urogenital schistosomiasis (Schistosoma haematobium), and the latter transmits intestinal schistosomiasis (Schistosoma mansoni), both of which affect nearly 240 million people globally. This study addresses the following questions: 1. Where are the most suitable habitats for intermediate host snails in the LSV? 2. Which environmental factors influence the geographical distribution of such snails in the LSV? 3. How will climate change shape future schistosomiasis transmission risk? Consistent with expectations, the SDMs reveal the following: 1) currently, Bu. africanus not only has a wide distribution across central Chikwawa and eastern Nsanje but is also concentrated in floodplains, and the LSV has few habitats that can support Bi. pfeifferi, 2) vegetation cover is the most important predictor of Bu. africanus distribution, whereas precipitation variables are most important for Bi. pfeifferi in the LSV, and 3) future projections indicate a moderate increase (4.4%) and east-ward shift in Bi. pfeifferi distribution, with patchy spatial coverage, and a significant expansion (46%) of suitable habitats for Bu. africanus in LSV. Understanding the spatial and temporal distributions of these snails is important for controlling and eliminating schistosomiasis.
Evaluation of the mechanical properties of implant-supported permanent crowns manufactured by additive and subtractive techniques: an in vitro study
Authors: Sahin Nilufer Ipek , Tokar Emre
Published: January 2025

Background
The development of composite resin materials that can be used with additive manufacturing techniques has contributed to the widespread use of 3D printers for producing implant-supported permanent crowns. The number of studies evaluating the surface roughness and fracture resistance of these materials is limited. This study aims to evaluate these features of implant-supported crowns produced by additive manufacturing using an experimental setup as close to clinical conditions as possible, and to compare the results with those of crowns produced by subtractive manufacturing methods. Crowns produced in three different thicknesses were used to determine the optimal wall thicknesses applicable in clinical practice.
Methods
In this in vitro study, two composite resins and one hybrid ceramic were used. A total of 180 crowns, produced in three different thicknesses (1.0, 1.5, and 2.0 mm), were cemented onto titanium abutments. Half of the crowns were designated as experimental, whereas the other half served as control groups (n = 10 for each material and thickness group). The samples in the experimental group were subjected to thermal aging to simulate one year of clinical aging. Surface roughness measurements were taken using a profilometer, and a universal testing machine was employed to assess fracture resistance. Two-way ANOVA was used to compare group means, Duncan’s post-hoc test was used for the comparative evaluation of subgroups, and a t-test was used to compare surface roughness results before and after thermal aging.
Results
Compared with those produced by the subtractive manufacturing technique, the crowns produced via the additive manufacturing technique presented lower surface roughness and lower fracture resistance values. Thermal aging did not significantly affect these parameters across all test groups (p > 0.05). There was no difference between the two manufacturing techniques at 1.0 mm (p > 0.05), whereas crowns produced using the subtractive manufacturing technique at thicknesses of 1.5 and 2.0 mm presented greater fracture resistance than those produced with the additive manufacturing technique (p < 0.01).
Conclusions
It was concluded that implant-supported permanent crowns produced by the additive manufacturing technique using composite resin meet clinical requirements regarding surface roughness and fracture resistance.
Overdose risk environment for people who use drugs in New Jersey: Imagining possible points of intervention for harm reduction practitioners
Authors: Sullivan Nora , Enich Michael , Flumo Rachel , Campos Stephanie , Flores Netanya , Mellor Jenna , O’Neill Caitlin , Nyaku Amesika N.
Published: January 2025

Background
The Risk Environment Framework is widely utilized theoretical framework for understanding the landscape of harm for people who use drugs (PWUD). This study sought to understand factors contributing to risk of overdose for PWUD in New Jersey. Understanding these factors can lead to improved policy interventions, programmatic targets, and a shared understanding that overdose risk is impacted by larger societal forces influencing PWUD.
Methods
Using a community based participatory design model, this study conducted 30 semi-structured, in-depth interviews with PWUD and naloxone distributors in New Brunswick and Newark, New Jersey from February to November of 2022. Thematic analysis was performed using a collaborative analytical approach.
Results
Risk factors for overdose fell into all four categories of Rhodes’s Risk Environment Framework – physical, social, economic, and policy. Many factors overlapped in multiple categories, and most factors had elements existing at both the macro and micro levels.
Conclusions
Interventions supporting PWUD should see overdose risk as an environmental, structural consideration, and be constructed to address comprehensive risks, rather than directing themselves exclusively at the individual level. Factors contributing to risk at the macro level included systemic and institutional concerns and stigma toward PWUD. At the micro level, mental health, substance use behaviors, treatment and recovery, and trauma were cited as potential risk factors.
A Face Recognition Based Attendance System with Geolocation and Real-Time Action Logging
Authors: Ray Debmalya
Published: January 2025

This paper introduces a cutting-edge face recognition-based attendance system, designed to address the limitations of traditional attendance methods through the integration of advanced machine learning, computer vision, and geospatial APIs. The system streamlines the attendance process by automating the identification and logging of attendees with high accuracy and efficiency. Key features include live video recognition for real-time face identification, an intuitive user registration module for enrolling new individuals, CSV-based logging for seamless data export and management, and geolocation-aware attendance tracking to ensure that records are not only time-accurate but also location-specific. This geospatial context provides valuable insights, particularly for distributed teams or multi-location setups. The implementation leverages Python, a versatile programming language, and integrates OpenCV for real-time video processing and face detection, ensuring quick and reliable face recognition even in dynamic environments. The graphical user interface (GUI) is developed using PyQt5, allowing for a user-friendly and responsive experience. This combination of powerful technologies ensures that the system is both scalable and adaptable, able to integrate easily into various organizational workflows, from small educational institutions to large-scale corporate environments. The system's practical application is validated through experimental results conducted in diverse settings, including workplaces, academic institutions, and security-sensitive environments. These results highlight the system’s exceptional accuracy, even under challenging conditions such as low lighting or crowded spaces. Furthermore, the system demonstrates its potential to enhance operational efficiency, reduce administrative overhead, and improve security by providing a reliable, context-aware solution for attendance management. In conclusion, this face recognition-based attendance system offers a modern, automated solution that combines the power of machine learning and computer vision with geospatial data, creating an intelligent, highly effective tool for attendance tracking across a wide range of industries and applications.
Кардиогенный шок. Клинические рекомендации Общероссийской общественной организации «Федерация анестезиологов и реаниматологов»
Authors: Григорьев Евгений Валерьевич , Баутин А. Е. , Киров М. Ю. , Шукевич Д. Л. , Корнелюк Р. А. , Кецкало М. В. , Левит А. Л. , Ефремов С. М. , Бабаев М. А. , Пионтек А. А.
Published: January 2025

INTRODUCTION: Cardiogenic shock (CS) is a critical tissue hypoperfusion with a mismatch between oxygen supply and consumption due to a significant decrease in cardiac output caused by acute dysfunction of one or both ventricles of the heart. Acute coronary syndrome is considered the most common cause of CS. OBJECTIVE: To create structured clinical guidelines for cardiogenic shock. MATERIALS AND METHODS: The article presents recommendations for cardiogenic shock in accordance with the scale of assessment of the levels of evidence (LLE) and the scale of assessment of the levels of recommendation (LR). RESULTS: The recommendations provide data on the epidemiology of CS, classification of shock by stages, diagnosis of shock taking into account the importance of hypoperfusion as the leading syndrome of CS and data on the method of primary intensive care, the choice of inotropic and vasopressor therapy, maintenance of oxygenation and features of mechanical circulatory support. CONCLUSIONS: The present clinical guidelines can be used to implement intensive care for CS in adult patients.
The Benefits of Activating Self-Regulation Behavior in Worldwide EFL Speaking Learning Contexts
Authors: Wijaya Kristian Florensio
Published: January 2025

Transforming worldwide EFL learners into more proficient L2 speakers is a challenging mission as speaking is not merely about the meaningful communication occurrences among interlocutors but also the strong willingness shouldered by EFL learners to regulate their certain behaviors and actions to achieve the targeted learning objectives fully. The previous research results strongly suggested that EFL educators establish, nurture, and reinforce their learners’ self-regulation at the commencement of speaking-focused learning activities in order to make them more confident L2 speakers who are willing to share their thoughts with other classroom learning community members. This present small-scale library study was a little attempt initiated by the researcher to investigate the potential benefits of activating EFL learners’ self-regulation behavior in worldwide speaking learning contexts. To fulfill this main study objective, the researcher conducted a thematic analysis by reviewing 30 previous self-regulation studies conducted globally to obtain more comprehensible research results. The publication years of these 30 published self-regulation articles ranged from 2013 until 2022 to produce more reliable research results. Based on the thematic analysis, there were two major themes yielded namely: (1) Highly self-regulated EFL learners can become more organized L2 speakers, and (2) highly self-regulated EFL learners can transform into more successful L2 speakers. In conformance with these research results, second language-speaking learning instructors are strongly encouraged to cultivate self-regulation behavior within EFL learners at the beginning of learning activities to gradually make them become more high-achieving and self-reliant speakers defining the best strategies suitable for their current speaking learning situations.
The effectiveness of using a combination of glucocorticosteroid and salicylic acid in the form of a solution for psoriasis vulgaris of the scalp
Authors: Arsenyeva A. A. , Orlov E. V. , Pakhomova J. M.
Published: January 2025

Psoriasis vulgaris (VP) occupies a leading place among all forms of psoriasis. The difficulty of treating the psoriatic process is associated with damage to the skin of the scalp, genitals, fold areas and nail apparatus. Finding an effective treatment for psoriasis in these difficult areas is an urgent task of modern dermatology. To evaluate the effectiveness of treatment of psoriasis vulgaris of the scalp using a solution containing a combination of glucocorticosteroid and salicylic acid. This article presents three clinical cases from the practice of a dermatovenerologist. Patients with vulgar psoriasis, predominantly affecting the scalp, were prescribed an Akriderm SK solution containing 0.05% betamethasone and 2% salicylic acid 2 times a day for 3 weeks in topical monotherapy or in combination with systemic therapy. As a result of the therapy, after 14 days, resolution of psoriatic plaques on the scalp was noted; after 21 days of treatment, residual mild erythema was noted, which subjectively did not bother the patients. The article demonstrates the clinical effectiveness of combination topical therapy using salicylic acid and betamethasone in the form of Akriderm SK solution for the treatment of psoriasis vulgaris of the scalp. The combination of these substances in the form of a solution has shown great effectiveness in the treatment of this localization of psoriasis.
Impact of CYP2D6 polymorphisms on the pharmacokinetics, efficacy, and safety of tamsulosin therapy in patients with benign prostatic hyperplasia
Authors: Abdullaev Sh. P. , Abdullaev Sh. P. , Shatokhin M. N. , Krasnov A. V. , Bochkov P. O. , Tuchkova S. N. , Loran O. B. , Sychev D. A.
Published: January 2025

Introduction. CYP2D6 is involved in the metabolism of tamsulosin, which is used to treat lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). However, the impact of carrying polymorphic variants of the CYP2D6 gene on the clinical efficacy and safety of tamsulosin therapy is still not well understood.

Aim. To evaluate the impact of CYP2D6 polymorphic variants on steady state concentration of tamsulosin (Cssmin), as well as their correlation with the efficacy and safety of therapy in patients with BPH.

Materials and methods. A single-center prospective study included 75 patients who completed all stages of the study. The median age of the patients was 69 years, body mass index was 27.17 ± 4.86 kg/m². 56 patients (74.67%) had comorbidities, which means the presence of at least one chronic disease in addition to the diagnosis of benign prostatic hyperplasia. 26 people (34.67%) were classified as polymorbid patients, i.e. having several comorbidities at once, while 19 patients (25.33%) had no comorbidities except for benign prostatic hyperplasia. Genotyping was performed by real-time polymerase chain reaction. Cssmin of tamsulosin was determined by HPLC-MS/MS. Efficacy of therapy was assessed using IPSS score and Qmax. Safety was assessed based on the incidence of adverse reactions.

Results. Carriage of CYP2D6*4 and CYP2D6*10 was found to be associated with statistically significant increases in Cssmin levels. However, the identified pharmacokinetic differences, carriage of CYP2D6 markers was not reflected in the clinical efficacy and safety of tamsulosin.

Conclusion. CYP2D6*4 and CYP2D6*10 may affect the Cssmin levels of the tamsulosin, but does not affect the clinical results of treatment.
Assessment of ecological risks to the health of students using a questionnaire method
Authors: Onopriev V. V. , Bolotova E. V. , Dudnikova A. V. , Batrakova L. V. , Abramenko A. G.
Published: January 2025

Introduction. The study of the prevalence of multiple chemical sensitivity (MCS) among young people is a significant medical and social issue. Sensitivity to environmental factors is not only an indicator of functional disorders but also one of the mechanisms negatively affecting health levels, disease development, quality of life, and reduced productivity. Multiple chemical sensitivity (MCS) represents one of the widespread variants of the body’s maladaptation to chemical components in the environment.

Aim. To assess environmental risks to students’ health through a questionnaire.

Materials and methods. Questionnaire survey using QEESI questionnaire of 287 student volunteers 95 males with a mean age of 20.2 ± 1.3 years and 192 females with a mean age of 20.5 ± 1.4 years. Data collection using the developed digital platform “EcoMedic”. Statistical processing was performed using MedCalc statistical programme.

Results. Among all 287 tested individuals, a total of 94 individuals (33.1%) were found to have MHF criteria. In the group of 135 first-year students tested, 39 individuals (28.8%) met the criteria for the diagnosis of MHF. A survey of 152 fourth-year students revealed that 55 (36.1%) met the criteria for the MHF diagnosis. Compared to the group of 1st year students with MHF, 4th year students suffering from MHF had higher intensity of respiratory/mucous membrane symptoms p = 0.0016, cardiac and chest symptoms, p = 0.001, gastrointestinal symptoms p = 0.0001 and cognitive disorders p = 0.0001.

Conclusions. The prevalence of multiple chemical intolerance among students was 33.1%. Worsening MCH symptoms include increased respiratory/mucosal, cardiac/thoracic, gastrointestinal, and cognitive symptoms.