bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review on Seismic Performance of L-Shaped Building Through Plan
Irregularities
Authors: Chhatani Yash , Pawade Prashant Y , Dabhekar Kuldeep R , Khedikar Isha P
Published: May 2021

The patterns of sporadic structure development have quickly expanded because of tasteful and restricted accessibility of land. Past examinations have indicated that the structures with design abnormality are harmed under solid ground movement. Auxiliary inconsistencies are significant elements which decline the seismic exhibition of the structures. Structures having basic anomalies bring about the lopsided circulation of the story float, exorbitant twist, etc. The irregularity discussed here are about plan irregularity which is available in re-participant corners and torsional anomaly which is caused by abrupt changes in firmness and twist enhancement factor in building. This study is to propose a feasible solution to build this kind of structure in seismically active areas using analytical methods with the assistance of ETABS software. The analysis shall be done through a comparable static horizontal power technique and reaction range examination (dynamic investigation). The basic reactions will estimated regarding story displacement, inter-story drift ratio, torsional irregularity ratio, torsional diaphragm rotation, normalized base shear force, and overturning moment, which are also called seismic response demands. The structure will be analyzed and compare with different types of other shape plan.
PEMENUHAN UNSUR POKOK DALAM PENGEMBANGAN DESTINASI WISATA GOA TABUHAN KABUPATEN PACITAN
Authors: Hilman Yusuf Adam
Published: May 2021

Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan destinasi wisata Goa Tabuhan, apakah banyak pihak yang terlibat dalam proses pengembangan tersebut? Dalam peneliti ini, peneliti menggunakan metode deskriptif kualitatif, dengan melakukan wawancara, observasi, serta dokumentasi. Berdasarkan hasil penelitian yang dilakukan oleh peneliti dapat disimpulkan bahwa Goa Tabuhan sudah layak menjadi sebuah Detinasi Wisata karena telah memenuhi unsur, seperti: memiliki destinasi serta atraksi pada obyek wisata, sudah di dukung infrastruktur dan sarana bagi pengunjung, serta aksesbilitas yang mudah, selain itu sudah terjalin kerjasama dan komunikasi yang baik antara pemerintah, masyarakat, media dan pihak swasta walaupun belum optimal, sebagai perwujudan pelaksanaan konsep Penta Helix.
ANALYSIS ON STUDENTS' MISTAKES IN WRITING RECOUNT TEXT (A CASE STUDY ON EIGHTH-GRADE STUDENTS OF MTS AL-AMIN NGETOS, NGANJUK)
Authors: Ekorini Puput Zuli
Published: May 2021

This study was conducted to analyze the students’ mistake in writing recount text. The subject of this research was the eighth-grade students of Mts Al-Amin Ngetos, Nganjuk which was consisted of 38 students. The researcher needs to analyze the students’ mistakes in writing recount text because writing is one of the four crucial skills to master English. In learning English at school students also learn how to write a text and organize their idea into a proper text. In getting the data, the researcher applied class evaluation research using purposive sampling technique which the sample was taken from 5 students’ recount text of the eight grade students of MTs Al-Amin Ngetos, Nganjuk. The researcher analyzed the students’ recount text based on the writing aspect which should be considered by the students in writing a recount text they were content, organization, grammar, vocabulary, and mechanics. The results showed that there were some mistakes made by the students, mostly their mistakes were inappropriate used of grammar and mechanics. So, the researcher provided suggestions for the teacher to help the students to know the writing aspects and learn how to apply them in writing text.
Manual of Practices in Physical Education in Professional and Technological Education Using the Free Application Efe – Eptfis
Authors: Viana Valderi Nascimento , Fecury Amanda Alves , Oliveira Euzébio de , Dendasck Carla Viana , Dias Claudio Alberto Gellis de Mattos
Published: May 2021

The application, EFE-EduFisEPT, acts as a support for physical education school activities, using historical-critical pedagogy occurs the confrontation of the scientific knowledge of the teacher with the empirical knowledge of the students, causing the development of a new vision and action in society. The purpose of this manual is to guide the physical education teacher about the content and practices for physical education classes in EPT and about the functionality of the free Application EFE – EPTFis. With its simple interface, the use of the application becomes easy and with intuitive functionality. This educational product exists as a support for the teacher to develop a more critical physical education, which understands the student beyond the biological being, that is, a social, political, cultural and historical being. In which each class, the student can understand that the content presented is linking to various dimensions of reality, contributing to a society vision based on values and attitudes towards the common goal: knowledge to generate fewer exclusions and discriminations.
Manuel de pratiques en éducation physique en éducation professionnelle et technologique utilisant l’application gratuite Efe – Eptfis
Authors: Viana Valderi Nascimento , Fecury Amanda Alves , Oliveira Euzébio de , Dendasck Carla Viana , Dias Claudio Alberto Gellis de Mattos
Published: May 2021

L’application, EFE-EduFisEPT, agit comme un soutien pour les activités de l’école d’éducation physique, en utilisant la pédagogie historique-critique se produit la confrontation de la connaissance scientifique de l’enseignant avec la connaissance empirique des élèves, provoquant le développement d’une nouvelle vision et l’action dans la société. Le but de ce manuel est de guider le professeur d’éducation physique sur le contenu et les pratiques des cours d’éducation physique en EPT et sur la fonctionnalité de l’application gratuite EFE – EPTFis. Avec son interface simple, l’utilisation de l’application devient facile et avec des fonctionnalités intuitives. Ce produit éducatif existe comme un soutien pour l’enseignant à développer une éducation physique plus critique, qui comprend l’élève au-delà de l’être biologique, c’est-à-dire un être social, politique, culturel et historique. Dans lequel chaque classe, l’élève peut comprendre que le contenu présenté est lié à différentes dimensions de la réalité, contribuant à une vision de la société basée sur des valeurs et des attitudes envers l’objectif commun: la connaissance pour générer moins d’exclusions et de discriminations.
Different Types of Curvature and Their Vanishing Conditions
Authors: Maheshkumar Kankarej Manisha
Published: May 2021

In the present paper, I studied different types of Curvature like Riemannian Curvature, Concircular Curvature, Weyl Curvature, and Projective Curvature in Quarter Symmetric non-Metric Connection in P-Sasakian manifold. A comparative study of a manifold with a Riemannian connection is done with a P-Sasakian Manifold. Conditions for vanishing for different types of curvature are also a part of the study. Some necessary properties of the Hessian operator are discussed with respect to all curvatures as well.
Tackling inflation in Nigeria: Monetary or fiscal policy? An empirical assessment of the effectiveness of the simultaneous implementation of the policies
Authors: Danlami Ibrahim Abdulhami , Hidthiir Mohamad Helmi , Hassan Sallahuddin
Published: May 2021

The study is aimed at empirically assessing between monetary policy and fiscal policy, the most effective in combating and tackling inflation in Nigeria, especially when implemented simultaneously – the effect of the concurrent implementation of the two policies on inflation. The variables of the policies are based on market information, money market equilibrium (LM Curve) for monetary policy, and product market equilibrium (IS Curve) for fiscal policy. The research makes use of the Autoregressive Distributed Lag Model (ARDL). Data for Nigerian was used from 1970 – 2016. The findings show that monetary and fiscal policies can be implemented concurrently as monetary policy is the best for a short-run solution during the fiscal policy for a long-run solution. The findings of the study are based on Nigerian data utilized for the period 1970 – 2016 and the method of data analysis adopted – ARDL, as well as variables selection based on the general equilibrium of money and product market. The findings of the study clearly show that monetary and fiscal policies can be used simultaneously to tackle inflation in Nigeria successfully, being effective in combating inflation in different periods (short-run or long-run). The study attempted to harmonize the incompatible theories and their policies to see whether the policies can be utilized concurrently since the policies are aimed at effecting price stability. The research’s findings confirm the feasibility of implementing the two policies concurrently and their effects to be felt or realized in different periods – short-runs and long-runs.
Sick of It All
Authors: Russell Jared
Published: May 2021

In a brief statement concerning our current global crisis, made one month into the Covid-19 pandemic, the philosopher Bernard Stiegler invited us to regard confinement as a gift. Drawing on his own experience of confinement following his incarceration for a series of bank robberies in the late 1970s, Stiegler argued that confinement can provide us with a much needed opportunity for reflection, and to reconnect with practices of traditional care and education—practices everywhere threatened by the destruction of intergenerational connectedness. “Confinement,” he wrote, “can revive the memory and meaning of past ways of life” (2020, 2). His hope appears to have been that in confinement and quarantine we might find the ability to think again, and to rethink what it means to be able to be and to do things together.
Economía digital, herramienta para mejorar la competitividad y productividad en las PYMES caso: Machala-Ecuador
Authors: Chuya-Chuya Jordan , Condo-Herrera Kerly , Uriguen-Aguirre Patricia , León-Serrano Lady
Published: May 2021

La investigación tiene como propósito analizar la economía digital como herramienta para mejorar la competitividad y productividad de las Pymes en la ciudad de Machala. Según las argumentaciones teóricas y empíricas que se han venido manejando en el diseño metodológico se aplicó una investigación descriptiva y explicativa. Por consiguiente, en la metodología, se realiza una revisión de literatura científica que permitió identificar procesos, determinantes y procedimientos inmersos en el tema economía digital y su impacto en las medianas y pequeñas empresas. Asimismo, el instrumento que se utilizó para la recolección de información fue la encuesta, mediante la aplicación de un cuestionario de 15 preguntas dirigidas a 160 pequeñas y medianas empresas, muestra que fue obtenida de la superintendencia de compañías (Supercia), partiendo de un universo de 271, las mismas que se vieron afectadas por el transcurso de los años, experimentando profundos cambios y un rápido crecimiento en la globalización digital. Por último, los resultados de la investigación demuestran que la economía digital benefició a muchas de las medianas y pequeñas empresas de la ciudad de Machala, de igual manera, impulsó la productividad de las organizaciones, permitiéndoles adaptarse y expandirse o consecuentemente cerrar o quebrar.
A Survey of Leisure Activities that the Elderly Desire
Authors: Pumpinyo Sumalee , Koocharoenprasit Saowaluck
Published: May 2021

The objective of this study was to explore both the indoor and outdoor activities that the elderly desire.  This study employed a questionnaire and in-depth interviews with people aged 50 years and older in Bangkok, Prathum Thani, Samut Pragarn and Phra Nakhon Si Ayutthaya provinces. The sample size was 185. The study showed that the outdoor activities that the elderly preferred were walking in the water, stretching activities and walking. The indoor activities that they preferred were muscle, brain and mind development. The most preferred outdoor activity of the elderly was walking in the water, while their favorite indoor activity was muscle development.
Biopolitics: Slavery, Racism and Eugenics in Latin America
Authors: Da Conceicao Maria Cristina Gomes
Published: May 2021

This article analyzes historical population changes as mechanisms of biopower in Latin America: during colonization, the crisis of indigenous groups, the arrival of enslaved Africans and, later, the immigration of free settler Europeans to replace both indigenous people and Africans as workforce and land property. The perspectives of settler colonialism and biopower are adopted to understand how sequential mechanisms of biopolitics were implemented in settler societies, through genocide and the assimilation of the majority, who were progressively being eliminated or transformed into minorities. The method includes literature review of the predominant concepts, discourses and practices established in the biopolitical process attached to settler colonialism, as well as the methods, institutions, policies and actors who built these modes of biopower. The results show the adoption of several biopolitics mechanisms, such as wars, epidemics, over-exploitation, land confiscation, the kidnaping of women, inferiorization, human trafficking and cruel punishments, during colonialism, as well as miscegenation, isolation and the marginalization and disappearing of those resisting in the transition to settler colonialism, when eugenic policies of fertility control and European immigration were implemented in order to whiten the population, which reinforced, articulated and validated the persistent racism, discrimination against and disadvantages forced upon these populations.
Elaboração de Suco Tropical de Umbu
Authors: Barros Aurianna Coelho , Bispo Helisvanhah Gretta Antunes Rodrigues , Reis Páulia Maria Cardoso Lima , Vilar Silvana Bélem de Oliveira , Albuquerque Junior Nailton de Macedo , Oliveira Iasmim Pereira , Figueiredo Douglas Vinicius Pinheiro de
Published: May 2021

O Nordeste é uma região que se destaca como principal produtor de frutas no Brasil, com grande diversidade de frutas tropicais ainda pouco exploradas, como por exemplo o umbu que possui quantidades significativas de nutrientes, nesse contexto, o presente estudo teve como objetivo desenvolver um suco tropical de umbu da polpa congelada e do fruto in-natura. Todas as amostras foram submetidas as análises microbiológicas, por 90 dias, análises físico-químicas  e a determinação de compostos bioativos, durante 120 dias de estocagem. Os resultados encontrados em ambos os sucos, apresentaram boas características microbiológicas, físico-químicas e nutritivas, no período de armazenamento estudado. Portanto, foram obtidos sucos de umbu com adequados parâmetros tecnológicos e alto potencial de valorização desta fruta regional, com características para atender a demanda crescente por alimentos nutritivos e com praticidade para o consumo.
Correlação da força de preensão palmar e estado nutricional em idosas praticantes de atividade física
Authors: Costa Ana Letícia Silva Nascimento , Rego Raysa dos Santos , Sousa Adriana Miranda , França Ruan Guilherme de Oliveira , Magalhães Bruna Cruz , Araujo Camila Guedes Borges de
Published: May 2021

O presente estudo teve como objetivo avaliar a força de preensão palmar e correlação com o estado nutricional de mulheres idosas. Estudo com abordagem transversal, quantitativo com amostra composta por 60 idosas com idade > 60 anos do sexo feminino, realizado no Centro de Convivência Dos Idosos, localizado em uma cidade do Nordeste Brasileiro. Foram estudadas varáveis para avaliação da composição corporal. O consumo alimentar foi avaliado por meio de Questionário de Frequência Alimentar (QFA) adaptado para idosos. Os dados da Força de Preensão Palmar (FPP) foram avaliados por meio da aplicação de formula. Para diferenças significativas adotou-se p<0,05. A pesquisa recebeu aprovação ética com número de parecer 3.248.005. A idade média da amostra final foi de 67,92±7,77. Houve prevalência de sobrepeso (45%) segundo o IMC. A ingestão calórica esteve acima da recomendação (1907,38±783,07). Entre as participantes com idades entre 60 a 69 anos de idade as médias tanto de FPP-D (26,70 + 2,37) como FPP-ND (25,23 + 1,73) apresentaram-se adequadas, já entre as que possuíam idade a cima de 70 anos a média da FFP-ND (18,93 + 3,55) esteve abaixo do esperado, encontrando-se adequado apenas o valor de FPP-D (20,53 + 3,73). Os resultados obtidos neste estudo sugerem que a força muscular das idosas se mantém preservada, o que influencia no desempenho funcional dessa população. O estado nutricional inadequado com sobrepeso das idosas deste estudo, é resultante do consumo de alimentos com densidade calórica elevada e baixa qualidade de macro e micronutrientes.
Análise comparativa do perfil epidemiológico do câncer de pele não-melanoma no Brasil, Nordeste e Maranhão, no período 2015-2019
Authors: Victor Yasmine Araújo , Costa Izolda Souza , Batalha Júnior Nilson de Jesus Pereira , Costa Sueli de Souza , Sampaio Cristianne Talitha Lopes , Campos Luísa Fernanda Pires
Published: May 2021

O acúmulo de mutações que resulta no crescimento desordenado de células é denominado câncer. Tal doença atinge milhares de pessoas no mundo e seu principal tipo é o de pele de origem não melanocítica, que inclui os carcionomas basocelular e espinocelular. Seu principal fator de risco é a exposição aos raios solares de forma desprotegida. Assim, sendo o Brasil um país de clima majoritariamente tropical, recebe uma quantidade de radiação significativa, tornando seus residentes mais suscetíveis aos danos de uma fotoexposição prolongada, principalmente na região nordeste. O objetivo deste trabalho foi realizar uma análise epidemiológica dos últimos cinco anos no Maranhão, no Nordeste e no Brasil sobre o câncer de pele não-melanoma, através de estudo observacional analítico transversal, quali-quantitativo, sendo que foram coletados dados do painel de oncologia disponível no DATASUS no período de 2015 a 2019. Os resultados demonstraram que o câncer de pele é o mais incidente e prevalente no Brasil, principalmente na população igual e maior que 70 anos, sendo o Rio Grande do Sul o estado mais acometido do Brasil e o Rio Grande do Norte, o do Nordeste. É mais prevalente na população feminina. A campanha de saúde “Dezembro Laranja” é hoje a principal estratégia de prevenção ao câncer de pele no Brasil.
Classification of specialty coffees using machine learning techniques
Authors: Ossani Paulo César , Rossoni Diogo Francisco , Cirillo Marcelo Ângelo , Borém Flávio Meira
Published: May 2021

Specialty coffees have a big importance in the economic scenario, and its sensory quality is appreciated by the productive sector and by the market. Researches have been constantly carried out in the search for better blends in order to add value and differentiate prices according to the product quality. To accomplish that, new methodologies must be explored, taking into consideration factors that might differentiate the particularities of each consumer and/or product. Thus, this article suggests the use of the machine learning technique in the construction of supervised classification and identification models. In a sensory evaluation test for consumer acceptance using four classes of specialty coffees, applied to four groups of trained and untrained consumers, features such as flavor, body, sweetness and general grade were evaluated. The use of machine learning is viable because it allows the classification and identification of specialty coffees produced in different altitudes and different processing methods.
Cenário epidemiológico dos casos notificados do HIV/Aids em Alagoas no período de 2009 a 2018
Authors: Mariano Daniella Marques dos Santos , Oliveira Keila Cristina do Nascimento , Hora Diego Pereira Gonçalo da , Lima Viviane Vanessa Rodrigues da Silva Santana , Alves Alysson Mariano , Cabral Thainá da Silva , Barros Marcela Cristina dos Santos , Santos Igor Michel Ramos dos , Oliveira Vanessa Vieira de Souza , Bezerra Roberto da Silva
Published: May 2021

Objetivo: Realizar um levantamento acerca do cenário epidemiológico de HIV/Aids em Alagoas. Método: Trata-se de estudo epidemiológico descritivo com abordagem quantitativa acerca do cenário do HIV e da Aids no estado de Alagoas no período de 2009 a 2018, utilizando dados secundários do SINAN por meio da Ficha de Notificação/Investigação Aids (pacientes com 13 anos ou mais) disponibilizados pela Secretaria de Saúde do Estado de Alagoas (SESAU), tabulados  em planilha eletrônica (Microsoft Excel®) e analisados estatisticamente através do software Statistical Package for the Social Sciences (SPSS) 22.0. As variáveis constituintes desse estudo são: dados sociodemográficos, vias de transmissão do HIV, critérios de definição de casos de HIV/Aids e evolução dos casos notificados. Resultados: Foram notificados 7.447 casos de HIV e Aids no período observado, sendo 62,9% de indivíduos do sexo masculino e 37,1% do sexo feminino, apresentando média de idade de 35 anos, com 71,5% de pessoas da raça/cor parda e 44,5% de pessoas analfabetas ou que possuem até o ensino fundamental completo. A categoria de exposição mais frequente foi a heterossexual, consideravelmente maior entre as mulheres. Dos 102 municípios de Alagoas, 96 deles (94,12%) apresentaram casos de HIV e Aids. O estudo revela ainda que há aumento anual do número de novos casos notificados de HIV e diminuição do número de óbitos por Aids. Conclusão: O perfil epidemiológico do HIV/Aids em Alagoas é permeado pelos processos de vulnerabilidade social e de gênero, com o cenário apresentando tendências de interiorização, juvenização, feminização e pauperização ao longo da série histórica analisada.
A rara associação de dermatomiosite secundária à Chikungunya em fase crônica
Authors: Arriaga Natacha Campos , Salles Louise Cavalcanti , Silva Francisco Theogenes Macedo , Costa Fabrício André Martins da , Rodrigues Cleonisio Leite , Augusto Kristopherson Lustosa
Published: May 2021

A chikungunya é uma doença tropical infecciosa causada pelo vírus Chikungunya (CHIKV), um vírus de RNA da família Togaviridae, gênero Alphavirus. É transmitida por mosquitos do gênero Aedes, infectados com o CHIKV. A doença evolui em três fases: aguda, subaguda e crônica, esta última tendo início após 3 meses de sintomatologia. A mialgia é um dos sintomas mais prevalentes na doença podendo ser intensa. Na literatura, alguns casos de Miopatia secundária à Chikungunya em fase aguda foram descritos, porém poucos foram relatados na fase crônica da doença. Apresentamos o caso de uma paciente feminina, que em 2016 desenvolveu fraqueza muscular progressiva às custas de dermatomiosite após dois anos da infecção pelo CHIKV.
Analysis of 9Be Fusion Cross Sections via a Simple Cluster Model
Authors: AYGUN Murat
Published: May 2021

The effects of different cluster configurations of 9Be nucleus on the cross-sections of 9Be + 28Si, 9Be + 64Zn, 9Be + 144Sm, 9Be + 186W and 9Be + 208Pb fusion reactions have been explored for the first time using a simple cluster approach. The real potential has been calculated based on the α + α + n, d + 7Li, 3H + 6Li, 3He + 6He and n + 8Be cluster cases of the 9Be nucleus while the imaginary potential is evaluated as Woods-Saxon potential. It has been seen that our results are in agreement with the experimental data. In addition to this, the fusion barrier height (VB) and barrier position (RB) values have been given for each reaction and cluster case.
Investigation of Injury patterns in Heavy-duty Single Vehicle crashes based on real-world accident data in Tamilnadu, India
Authors: Rangam Harikrishna , Sivasankaran Sathish Kumar , Balasubramanian Venkatesh
Published: May 2021

According to the reports of NITI (National Institute of Transforming India) Aayog Freight 2018, Road freight is the prime mode (59%) of transport in India with the highest per ton-mile cost than rail or water freight (NITI Aayog, 2018). This road freight usually uses heavy-duty vehicles to transmit voluminous goods and services to the destination in time. Due to this, the heavy-duty vehicle population increased on the Indian roads. Heavy-duty vehicle crashes cause a substantial economic burden to the nation and result in more severity to the involved because of differences in weight, speed, and size. Among heavy-duty vehicle crashes, a significant proportion of crashes are heavy-duty single-vehicle crashes. Single-vehicle crashes are those crashes where the vehicle drivers either involve in self-skidding or hit a stationary object (like a tree). The purpose of this study is to investigate the injury pattern in heavy-duty single vehicle crashes.

For this study, the data is extracted from the RADMS (Road Accident Database Management System) database and linked with hospital data. This data includes demographic information, road, environmental and injury characteristics. Later, descriptive statistics performed on the dataset to analyse all heavy-duty single-vehicle crashes between January 2013 and December 2018. Overall, 4704 single heavy-duty vehicle crashes occurred during this period, among which 1244 were fatal crashes. Results show that male drivers aged 26 to 64 years old suffered more fatalities (88%), followed by the 18-25 age group (8%). Examination of injury information found that heavy-duty vehicle drivers mostly sustained multiple injuries (9.05%), head injuries (5.05%), followed by leg injuries (4.29%). The results showed that specific road and environmental factors increase the chance of fatal crashes among heavy-duty vehicle drivers. Furthermore, the proposed study gives insight into the injury characteristics and key contributing factors causing heavy-duty single-vehicle crashes. Finally, this study provides appropriate countermeasures and techniques that can mitigate heavy-duty single-vehicle collisions.
Medeni Usul Hukukunda Teksif İlkesi
Authors: MAZLUM Nagihan
Published: May 2021

Teksif ilkesi, usul işlemlerinin, belirli bir usul kesitine kadar mahkeme önüne getirilmesini, öngörülen usul kesitinin tamamlanmasından sonra ileri sürülen ya da getirilen işlemlerin mahkemece dikkate alınmamasını öngören yargılama hukuku ilkesidir. HMK’da düzenlenmemiştir. Ancak gerek Yargıtay tarafından gerekse de doktrin tarafından göz önünde bulundurulan bir ilke konumundadır. Bu çalışma kapsamında da teksif ilkesi kavram, yargılamaya egemen olan diğer ilkeler ile ilişkisi, uygulama alanı ve kanun yolunda bakımından ayrıntılı olarak açıklanmaya çalışılacaktır.
Suç İsnadına veya Medeni Hak ve Yükümlülüklere İlişkin Uyuşmazlıklarda Duruşmaya Video Konferans Yöntemiyle Uzaktan Katılma
Authors: TANER Fahri Gökçen , YILDIRIM Akif
Published: May 2021

Teknolojinin hızla geliştiği bir çağda, hukuk sistemlerinin buna kayıtsız kalması ve teknolojinin imkânlarından yararlanılmaması düşünülemez. developments Bu gelişmelere paralel olarak, görüntülü ve sesli iletişim teknikleri kullanılarak, ilgililerin duruşmaya (video konferans yöntemiyle) uzaktan katılımları sağlanmaktadır. Bu yöntemin kullanılması hukuk sistemlerine, transfer masraflarından tasarruf etme ve yargılamayı makul sürede tamamlama gibi birçok avantaj sağlamaktadır. Bununla beraber anılan yöntem, adil yargılanma hakkı kapsamındaki birçok güvenceyi sınırlamaktadır. Çalışmada, terminolojik bir tartışmanın ardından adil yargılanma hakkı ile ilgili genel esaslar açıklanmıştır. Devamında, medeni hak ve yükümlükler ile suç isnadına ilişkin uyuşmazlıklarda video konferans yönteminin kullanılması, Avrupa İnsan Hakları Mahkemesi ve Anayasa Mahkemesi içtihatları açısından değerlendirilmiştir. Çalışmanın sonunda ise mevzuat ile Yargıtay ve bölge adliye mahkemelerinin içtihadı ortaya konularak, duruşmaya uzaktan katılan her bir süje bakımından değerlendirmeler yapılmıştır.
The Importance of Serum Leptin Level in Chronic Viral Hepatitis B and C
Authors: ŞENOL Arzu , AŞCI TORAMAN Zülal
Published: May 2021

OBJECTIVE: Leptin plays an important role in inflammation and liver fibrogenesis in viral liver diseases. In this study, determination of serum leptin level and the effect of leptin levels on liver inflammation and fibrosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) cases were evaluated.MATERIALS AND METHODS: In this prospective clinical research study, a total of 75 CHB patients, 36 CHC patients, and a 51 control group were included. Liver biopsy specimens were scored using Ishak histological scoring system. Serum leptin levels were determined by ELISA method.RESULTS: Overall, 39 of CHB cases were female while 36 was male, there were 18 female and 18 male cases of CHC, while the control group consisted of 26 female and 25 male. Serum leptin levels were statistically significantly higher in CHB (2.81±0.38) and CHC (2.97±0.35) cases than in the control group (1.39±0.08) (p: 0.001). However, there was no statistically significant difference in serum leptin level between CHC and CHB cases. There was no statistically significant difference between serum leptin levels and age, gender, and biochemical parameters (P> 0.05). Serum leptin levels were statistically significantly higher in patients with significant fibrosis in chronic hepatitis B and KHC patients compared to those with mild fibrosis (P<0.05).CONCLUSION: Leptin plays a role in liver inflammation and fibrosis in CHB and CHC. In CHB and CHC patients, leptin levels can be used to evaluate the degree of advanced fibrosis and in clinical follow-up, but larger studies are needed.
Cathelicidin LL37 Promotes Osteogenic Differentiation in vitro and Bone Regeneration in vivo
Authors: Li Lunhao , Peng Yiyu , Yuan Qingyue , Sun Jing , Zhuang Ai , Bi Xiaoping
Published: May 2021

Different types of biomaterials have been used to repair the defect of bony orbit. However, exposure and infections are still critical risks in clinical application. Biomaterials with characteristics of osteogenesis and antibiosis are needed for bone regeneration. In this study, we aimed to characterize the antimicrobial effects of cathelicidin-LL37 and to assess any impacts on osteogenic activity. Furthermore, we attempted to demonstrate the feasibility of LL37 as a potential strategy in the reconstruction of clinical bone defects. Human adipose-derived mesenchyme stem cells (hADSCs) were cultured with different concentrations of LL37 and the optimum concentration for osteogenesis was selected for further in vitro studies. We then evaluated the antibiotic properties of LL37 at the optimum osteogenic concentration. Finally, we estimated the efficiency of a PSeD/hADSCs/LL37 combined scaffold on reconstructing bone defects in the rat calvarial defect model. The osteogenic ability on hADSCs in vitro was shown to be dependent on the concentration of LL37 and reached a peak at 4 μg/ml. The optimum concentration of LL37 showed good antimicrobial properties against Escherichia coli and Staphylococcus anurans. The combination scaffold of PSeD/hADSCs/LL37 showed superior osteogenic properties compared to the PSeD/hADSCs, PSeD, and control groups scaffolds, indicating a strong bone reconstruction effect in the rat calvarial bone defect model. In Conclusion, LL37 was shown to promote osteogenic differentiation in vitro as well as antibacterial properties. The combination of PSeD/hADSCs/LL37 was advantageous in the rat calvarial defect reconstruction model, showing high potential in clinical bone regeneration.
A Monte Carlo Simulation Approach in Non-linear Structural Dynamics Using Convolutional Neural Networks
Authors: Bamer Franz , Thaler Denny , Stoffel Marcus , Markert Bernd
Published: May 2021

The evaluation of the structural response statistics constitutes one of the principal tasks in engineering. However, in the tail region near structural failure, engineering structures behave highly non-linear, making an analytic or closed form of the response statistics difficult or even impossible. Evaluating a series of computer experiments, the Monte Carlo method has been proven a useful tool to provide an unbiased estimate of the response statistics. Naturally, we want structural failure to happen very rarely. Unfortunately, this leads to a disproportionately high number of Monte Carlo samples to be evaluated to ensure an estimation with high confidence for small probabilities. Thus, in this paper, we present a new Monte Carlo simulation method enhanced by a convolutional neural network. The sample-set used for this Monte Carlo approach is provided by artificially generating site-dependent ground motion time histories using a non-linear Kanai-Tajimi filter. Compared to several state-of-the-art studies, the convolutional neural network learns to extract the relevant input features and the structural response behavior autonomously from the entire time histories instead of learning from a set of hand-chosen intensity inputs. Training the neural network based on a chosen input sample set develops a meta-model that is then used as a meta-model to predict the response of the total Monte Carlo sample set. This paper presents two convolutional neural network-enhanced strategies that allow for a practical design approach of ground motion excited structures. The first strategy enables for an accurate response prediction around the mean of the distribution. It is, therefore, useful regarding structural serviceability. The second strategy enables for an accurate prediction around the tail end of the distribution. It is, therefore, beneficial for the prediction of the probability of failure.
Analysis of COVID-19 Concerns Raised by the Construction Workforce and Development of Mitigation Practices
Authors: Bou Hatoum Makram , Faisal Ali , Nassereddine Hala , Sarvari Hadi
Published: May 2021

The coronavirus outbreak has created a global health crisis that has disrupted all industries, including the construction industry. Following the onset of the pandemic, construction workers faced and continue to face unprecedented safety and health challenges. Therefore, construction employers established new safety precautions to protect the health and safety of the workforce and minimize the spread of the virus. The new precautions followed the advice and guidelines offered by different health and safety agencies like the Occupational Safety and Health Administration (OSHA), Centers of Disease Control and Prevention (CDC), and the Associated General Contractors of America (AGC). With construction projects resuming operations, it becomes important to analyze the coronavirus-related health and safety concerns of construction workforce and understand how the new safety procedures can assist on jobsites. Existing studies mostly focused on interviews and surveys with construction companies to understand the impact on project performance and supply chains. However, no study has yet to analyze the United States construction workforce. This paper fills the gap by providing a qualitative descriptive analysis of the COVID-19 complaints data gathered by OSHA from construction jobsites. Information gathered by OSHA includes the jobsite location, the North American Industry Classification System (NAICS) of the construction company, the type of the complaint (i.e., formal or non-formal), and a thorough description of the complaint. N-grams were employed to analyze the complaints, detect trends, and compile a list of the most frequent concerns reported by the workforce. The analysis of the complaints data identifies safety practices that were most violated, highlights major safety and health concerns for construction workers, and pinpoints geographical areas that have seen a surge in complaints. The study also synthesized the existing research corpus and compiled a list of 100 best practices that construction employers can adopt to mitigate the concerns of the workforce. The findings of this study provide insights into the safety and health trends on construction sites, lay the foundation for future work of academicians and practitioners to address the concerns faced by construction workers, and serve as lessons learned for the industry in the case of any future pandemic.
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin
Authors: Liu Haiyan , Qiu Chun , Wang Bo , Bing Pingping , Tian Geng , Zhang Xueliang , Ma Jun , He Bingsheng , Yang Jialiang
Published: May 2021

Carcinoma of unknown primary (CUP) is a type of metastatic cancer, the primary tumor site of which cannot be identified. CUP occupies approximately 5% of cancer incidences in the United States with usually unfavorable prognosis, making it a big threat to public health. Traditional methods to identify the tissue-of-origin (TOO) of CUP like immunohistochemistry can only deal with around 20% CUP patients. In recent years, more and more studies suggest that it is promising to solve the problem by integrating machine learning techniques with big biomedical data involving multiple types of biomarkers including epigenetic, genetic, and gene expression profiles, such as DNA methylation. Different biomarkers play different roles in cancer research; for example, genomic mutations in a patient’s tumor could lead to specific anticancer drugs for treatment; DNA methylation and copy number variation could reveal tumor tissue of origin and molecular classification. However, there is no systematic comparison on which biomarker is better at identifying the cancer type and site of origin. In addition, it might also be possible to further improve the inference accuracy by integrating multiple types of biomarkers. In this study, we used primary tumor data rather than metastatic tumor data. Although the use of primary tumors may lead to some biases in our classification model, their tumor-of-origins are known. In addition, previous studies have suggested that the CUP prediction model built from primary tumors could efficiently predict TOO of metastatic cancers (Lal et al., 2013; Brachtel et al., 2016). We systematically compared the performances of three types of biomarkers including DNA methylation, gene expression profile, and somatic mutation as well as their combinations in inferring the TOO of CUP patients. First, we downloaded the gene expression profile, somatic mutation and DNA methylation data of 7,224 tumor samples across 21 common cancer types from the cancer genome atlas (TCGA) and generated seven different feature matrices through various combinations. Second, we performed feature selection by the Pearson correlation method. The selected features for each matrix were used to build up an XGBoost multi-label classification model to infer cancer TOO, an algorithm proven to be effective in a few previous studies. The performance of each biomarker and combination was compared by the 10-fold cross-validation process. Our results showed that the TOO tracing accuracy using gene expression profile was the highest, followed by DNA methylation, while somatic mutation performed the worst. Meanwhile, we found that simply combining multiple biomarkers does not have much effect in improving prediction accuracy.
Recent Progress of the Practical Applications of the Platinum Nanoparticle-Based Electrochemistry Biosensors
Authors: Yu Han , Yu Jingbo , Li Linlin , Zhang Yujia , Xin Shuquan , Ni Xiuzhen , Sun Yuan , Song Kai
Published: May 2021

The detection of biomolecules using various biosensors with excellent sensitivity, selectivity, stability, and reproducibility, is of great significance in the analytical and biomedical fields toward achieving their practical applications. Noble metal nanoparticles are favorable candidates due to their unique optical, surface electrical effect, and catalytic properties. Among these noble metal nanoparticles, platinum nanoparticles (Pt NPs) have been widely employed for the detection of bioactive substances such as glucose, glutamic acid, and hormones. However, there is still a long way to go before the potential challenges in the practical applications of biomolecules are fully overcome. Bearing this in mind, combined with our research experience, we summarized the recent progress of the Pt NP-based biosensors and highlighted the current problems that exist in their practical applications. The current review would provide fundamental guidance for future applications using the Pt NP-based biosensors in food, agricultural, and medical fields.
Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
Authors: Murros Kari E. , Huynh Vy A. , Takala Timo M. , Saris Per E. J.
Published: May 2021

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are evidently linked to the pathogenesis of PD. Although a multitude of studies have investigated microbial etiologies of PD, the microbial role in disease progression remains unclear. Here, we show that Gram-negative sulfate-reducing bacteria of the genus Desulfovibrio may play a potential role in the development of PD. Conventional and quantitative real-time PCR analysis of feces from twenty PD patients and twenty healthy controls revealed that all PD patients harbored Desulfovibrio bacteria in their gut microbiota and these bacteria were present at higher levels in PD patients than in healthy controls. Additionally, the concentration of Desulfovibrio species correlated with the severity of PD. Desulfovibrio bacteria produce hydrogen sulfide and lipopolysaccharide, and several strains synthesize magnetite, all of which likely induce the oligomerization and aggregation of α-synuclein protein. The substances originating from Desulfovibrio bacteria likely take part in pathogenesis of PD. These findings may open new avenues for the treatment of PD and the identification of people at risk for developing PD.
Cardiovascular Implantable Electronic Device Infection and New Insights About Correlation Between Pro-inflammatory Markers and Heart Failure: A Systematic Literature Review and Meta-Analysis
Authors: Zerbo Stefania , Perrone Giulio , Bilotta Clio , Adelfio Valeria , Malta Ginevra , Di Pasquale Pietro , Maresi Emiliano , Argo Antonina
Published: May 2021

Introduction: Surgical approaches to treat patients with abnormal pro-inflammatory parameters remain controversial, and the debate on the correlation between hematological parameter alteration in cardiac implantable electronic device (CIED) infection and the increase in mortality continues.

Methods: We performed a systematic review using the PubMed, Scopus, and Cochrane Library databases. Twenty-two articles from May 2007 to April 2020 were selected and divided according to the following topics: prevalence of microbes in patients with CIED infection; characteristics of patients with CIED infection; comparison between patients who underwent and did not undergo replantation after device extraction; and correlation between alteration of hematological parameters and poor prognosis analysis.

Results: Epidemiological analysis confirmed high prevalence of male sex, staphylococcal infection, and coagulase-negative staphylococci (CoNS). The most common comorbidity was heart failure. Complete removal of CIED and antimicrobial therapy combination are the gold standard. CIED replacement was associated with higher survival. High preoperative white blood cell count and C-reactive protein levels increased the risk of right ventricular failure (RVF) development. Increased red blood cell distribution width (RDW) value or decreased platelet count was correlated with poor prognosis. No correlation was noted between preoperative leukocytosis and CIED infection.

Discussion: A relevant correlation between leukocytosis and RVF was observed. Heart failure may be related to high RDW values and decreased platelet count. Data on the correlation between hematological parameter alteration and poor prognosis are missing in many studies because of delayed implantation in patients showing signs of infection.
Convergent Evolution of Wingbeat-Powered Anti-Bat Ultrasound in the Microlepidoptera
Authors: O’Reilly Liam Joseph , Harris Brogan John , Agassiz David John Lawrence , Holderied Marc Wilhelm
Published: May 2021

Bats and moths provide a textbook example of predator-prey evolutionary arms races, demonstrating adaptations, and counter adaptations on both sides. The evolutionary responses of moths to the biosonar-led hunting strategies of insectivorous bats include convergently evolved hearing structures tuned to detect bat echolocation frequencies. These allow many moths to detect hunting bats and manoeuvre to safety, or in the case of some taxa, respond by emitting sounds which startle bats, jam their biosonar, and/or warn them of distastefulness. Until now, research has focused on the larger macrolepidoptera, but the recent discovery of wingbeat-powered anti-bat sounds in a genus of deaf microlepidoptera (Yponomeuta), suggests that the speciose but understudied microlepidoptera possess further and more widespread anti-bat defences. Here we demonstrate that wingbeat-powered ultrasound production, likely providing an anti-bat function, appears to indeed be spread widely in the microlepidoptera; showing that acoustically active structures (aeroelastic tymbals, ATs) have evolved in at least three, and likely four different regions of the wing. Two of these tymbals are found in multiple microlepidopteran superfamilies, and remarkably, three were found in a single subfamily. We document and characterise sound production from four microlepidopteran taxa previously considered silent. Our findings demonstrate that the microlepidoptera contribute their own unwritten chapters to the textbook bat-moth coevolutionary arms race.
Genome Sequencing and Assembly Strategies and a Comparative Analysis of the Genomic Characteristics in Penaeid Shrimp Species
Authors: Yuan Jianbo , Zhang Xiaojun , Li Fuhua , Xiang Jianhai
Published: May 2021

Penaeid shrimp (family Penaeidae) represents one of the most economically and ecologically important groups of crustaceans. However, their genome sequencing and assembly have encountered extreme difficulties during the last 20 years. In this study, based on our previous genomic data, we investigated the genomic characteristics of four penaeid shrimp species and identified potential factors that result in their poor genome assembly, including heterozygosity, polyploidization, and repeats. Genome sequencing and comparison of somatic cells (diploid) of the four shrimp species and a single sperm cell (haploid) of Litopenaeus vannamei identified a common bimodal distribution of K-mer depths, suggesting either high heterozygosity or abundant homo-duplicated sequences present in their genomes. However, penaeids have not undergone whole-genome duplication as indicated by a series of approaches. Besides, the remarkable expansion of simple sequence repeats was another outstanding character of penaeid genomes, which also made the genome assembly highly fragmented. Due to this situation, we tried to assemble the genome of penaeid shrimp using various genome sequencing and assembly strategies and compared the quality. Therefore, this study provides new insights about the genomic characteristics of penaeid shrimps while improving their genome assemblies.