bluuebunny/crossref_metadata_2025 huggingface dataset:
Imaginário, saberes e religiosidade amazônica na poesia de Bruno de Menezes
Authors: Martins Guilherme Luís Mendes
Published: September 2024

Este trabalho busca-se analisar a literatura na perspectiva negra. Neste sentido um autor que pode ser trabalhado em sala de aula é Bruno de Menezes. Poeta modernista que consegue dar ao negro uma posição até então subestimada por outros autores. A partir da leitura de Bruno de Menezes os alunos podem ser convidados a fazer sua própria poesia. Deste modo, não somente com o poeta Bruno de Menezes, mas qualquer assunto relacionado a África pode ser uma forma de incentivar e estimular a poesia. Mas aqui destaca-se a literatura brasileira, pois ocorrem dois momentos. No primeiro, é observada a condição escravista dos negros, de modo que suas ações expressam somente a opressão vivida pelos mesmos. O domínio das letras pertencia à elite intelectual, senhores de escravos que enviavam seus filhos a Europa e quando retornavam, continuavam o processo de escravidão. A partir da influência iluminista houve certo avanço no que diz respeito à concepção de política escravista. No entanto, isto não foi suficiente para mudar o regime, uma vez que havia o interesse capitalista. O negro de escravo passa a ser operário da classe burguesa. Neste momento, poetas como Castro Alves, ainda apresentam um negro sem reação diante da opressão vivida por sua classe. Num segundo momento, especialmente no século XX, poetas da Escola Modernista apontam para as contribuições do negro, quer sejam no âmbito cultural, econômico, religioso, político e social. Um grande expoente foi o poeta Bruno de Menezes, o qual enfatiza não só a estética negra como algo belo, mas, sobretudo as contribuições dos agentes negros que a historiografia e a literatura ofuscaram. Saindo da perspectiva positivista que exaltava somente grandes heróis como a Princesa Isabel, pois mesmo ela segundo consta foi influenciada pelos milagres de Nossa Senhora Aparecida quando os elos da corrente de um negro foram quebrados por um milagre da santa.  Assim, as mães pretas, os capoeiristas dentre outros, são cidadãos que aparecem como sujeitos do processo de emancipação negra. Neste sentido, acredita-se que os negros tomam consciência de classe e inauguram um novo momento dentro da literatura recebendo influências da concepção marxista para expressar um novo contexto que é de suma importância para romper com teorias literárias burguesas as quais reduziam a literatura numa concepção estrutural passando para uma escrita engajada. Isto não significa dizer que antes os negros não escreviam, entretanto suas produções não eram consideradas interessantes para os que desejavam permanecer com seu status quo.  Negavam assim a contribuição daqueles que foram instrumentos de desenvolvimento do Brasil. Este estudo dará ênfase para o segundo momento da literatura brasileira baseando-se nos poemas de Bruno de Menezes bem como nos trabalhos publicados pelos autores Costa(2009); Luciano e Neto (2009).
Saúde mental do professor universitário: Fatores e condições de trabalho
Authors: De Barros Betijane Soares , De Farias Ivete Medeiros , de Araujo Carla Waleska Gomes , Moura Luciane Queroz , Almeida Bernard Pereira , Filho José Fernandes dos Santos , Pimentel Izeni Teixeira
Published: September 2024

A saúde mental do professor universitário é um assunto de extrema importância, pois esses profissionais enfrentam uma série de desafios que podem impactar negativamente seu bem-estar emocional. Uma vez reconhecido que o ambiente de trabalho influencia na percepção de qualidade de vida e na condição mental. O professor universitário, no cumprimento de sua função, está exposto a inúmeros fatores que podem interferir diretamente na sua saúde mental. O objetivo desse trabalho é identificar e análise da percepção dos professores universitários, a respeito de sua saúde mental. Trata-se de uma pesquisa de revisão bibliográfica a fim de construir um referencial teórico. Os resultados sugerem que a carga de trabalho excedente é ocasionada pelas multifunções atribuídas ao cumprimento das atividades de ensino, esse fator tem contribuído para a diminuição da saúde mental dos mesmos. Os resultados demonstram ainda que as relações sociais, assim como as relações ambientais, influenciam na saúde mental dos professores universitários, tanto em aspectos positivos, quanto negativos, porém, tais fatores associados à carga de trabalho excedente contribuem no aumento das doenças mentais relacionadas ao ambiente de trabalho.
Neurilemmoma at the Junction of Hard and Soft Palate: A Case Report
Authors: P S Kaaviya Tharsini , V Veeravarmal , Nirmal Madhavan , Nassar Mohamed
Published: September 2024

Neurilemmoma is a benign peripheral nerve sheath tumour arising from schwann cells. It is relatively uncommon; around 25% to 48% of all cases occur in the Head and Neck region. Only 1% occur in the oral cavity and tongue being the most common site. Here, we report a case of a 40-year-old female patient with swelling in the junction of the hard and soft palate on the left side for 15 years. Due to its duration, site, and nature, it mimicked a glandular neoplasm. Clinical, histopathological, and immunohistochemical findings confirmed it as a neural tumour -Neurilemmoma.
DRUGS SAFETY IN CHILDREN
Authors: Laljee Sadhna , Afshan Siddiq  , Wahid Shahana , Siddiqui Nausheen Hameed
Published: September 2024

Background: There is a need to promote drug-related safety in children and prevent them from drug-related toxicities. Understanding pediatric pharmacology, drug dosing, and physiological differences between children and adults is crucial for ensuring safe and effective pediatric care. Objectives: The focus of the current review is the safety and efficacy of drugs in children that involve medication errors and adverse drug reactions. The present study includes awareness of past medication-related incidents, off-label drug usage, inappropriate antibiotic prescriptions, adverse reactions to over-the-counter drugs, and cases of pharmaceutical poisoning in children. Methodology: Pertinent literature databases from search engines like Google Scholar and PubMed were retrieved and analyzed, and WHO and FDA guidelines were followed. Results: The literature survey showed that these problems can be overcome by taking safety measures and following evidence-based practice recommended by the FDA, reducing dosing errors, and preventing ADRs. The Best Pharmaceuticals for Children Act (BPCA) and Pediatric Research Equity Act (PREA) has made efforts in conducting drug research and improving pediatric labelling. Conclusion: A warning showing more recent information about contraindications must be mentioned in pharmaceutical labelling so the patient and doctors would be better aware of drug contraindications and their adverse effects.
COPD RISK IN PAKISTANI PUNJABI POPULATION: ROLE OF GATM, PSMA4, AND CHRNA5-A3-B4 GENE VARIANTS
Authors: Kousar Samra , Mahmood Atif , Sajjad Mohsin , Rehman Atia , Tayyab Ujala , Khan Ayesha Shahbaz , Shahid Mariam
Published: September 2024

Background: Chronic obstructive pulmonary disease (COPD) is a complex, multifactorial and polygenic disease concerning genetic and environmental factors. Objectives: The selected single nucleotide polymorphisms (SNPs) within or between potential candidate genes were studied to find the association with the onset of COPD disease in the Punjabi population of Pakistan. Methods: 254 COPD patients and 219 control subjects were enrolled for this case-control study. After a literature review and with the help of bioinformatics tools, risk-associated deleterious SNPs residing within or among genes GATM, PSMA4, CHRNA3, CHRNA5, and CHRNB4 were selected to evaluate their association with COPD. Following the mini-sequencing technique, the disease’s association analysis was done using PLINK v1.9 and SHEsis Plus. Results: The mean age of cases was 48.9 ± 9.04 years (N=254), comprising 55.1% males and 44.9% females with 36.6% positive family history of COPD. ‘C’ alleles for rs200551904, rs199547652 and rs1288775 are associated with COPD (p-value 9.70x10-9, 1.14x10-5 and 7.45x10-4 respectively), whereas the ‘CC’ genotype of rs8053 seems to be a protective factor for the disease. The variants rs1288775 and rs199547652 remained associated even with adjusting results for smoking exposure (p-value 0.002 and 1.22 x10-6, respectively). Haplotype analysis for rs1145086, rs1288775, rs8053, rs77994111, rs16969968, rs200551904, rs199547652, rs19968256, and rs181037724 shows that four of the haplotypes H4, H9, H10 and H14, (GATAGGACC; CACAAGACC; CATAGGACC; GACAAGACC respectively), are associated with the disease, while two haplotypes, H1 and H11 (CACAGGCCC and CGCAGGACC respectively), are protective factors against the disease. Conclusion: The association of COPD with chromosome 15 variants in the Punjabi population is reported in this study.
The Impact of Empowering Saudi Women on Entrepreneurship in light of The Aspirations of Vision 2030: An Applied Study on Female Entrepreneurs in The Kingdom of Saudi Arabia
Authors: Al-Dahash Shekah , Ibrahim Ahmed Sumia
Published: September 2024

The impact of empowering women during the different stages of Saudi society the study seeks to know the impact of empowering Saudi women in entrepreneurship of various kinds, especially social and economic, and to identify the resources of women’s empowerment and their effectiveness on the ground in all its stages. The study also reviews the achievements of empowering Saudi women in entrepreneurship during the Kingdom’s Vision 2030 The study found that multiple areas of empowerment, where the beginning of female entrepreneurs was limited to domestic skills to do business and share business related to the economic activity of the family The questionnaire was adopted as a tool in collecting research data, as the results indicated the importance of the impact of entrepreneurship on women’s personal and economic empowerment with positive answers and also in empowering women socially in terms of improving children’s education and providing community services.

Keywords: Empowering Women – Entrepreneurship – Vision 2030 – Saudi Arabia
Evaluation of the Efficacy and Aerodynamic Intervention of Face Shields against Pathogenic Aerosols Using Computational Fluid Dynamics and Wells-Riley Transport Model
Authors: Agar Joshua
Published: September 2024

The COVID-19 pandemic has unraveled the historical resistance to the acknowledgment of airborne transmissions. As it is a respiratory disease, the disease is mainly transmitted by coughs and sneezes, which introduce pathogenic aerosols that float while being transported in the air. As the effectiveness of the public health response is just as far as the working understanding of the mechanisms of transmission, physical interventions like wearing face shields – even in public places – were being mandated in the Philippines. With respiratory diseases like COVID-19 being airborne, face shields intervene aerodynamically and not ballistically. Mandating face shields in public spaces has widened the range of scenarios, especially now with the different angles of attack from which the emissions can be coming. The coughs coming from different angles of attack, as well as the performance of face shields in the reduction of transmission, are simulated in an unsteady computational fluid dynamics analysis, with large eddy simulation as the turbulence model. The risk of infection is evaluated based on the transport model of quanta used in the Wells-Riley formulations. Results showed that the face shield is only effective against coughs hitting perpendicular to the surface. At other angles of attack, the protection by the face shield diminishes, and wearing a face shield can instead increase the infection risk against pathogenic aerosols.
Presence of Extended Spectrum Beta-lactamase-producing Escherichia coli from Meat Handler and Poultry Cecal Samples
Authors: Sarmiento Aila Nell , Micu Remedios , Dayrit Geraldine
Published: September 2024

Antimicrobial resistance is a global health issue that affects humans, animals, and agriculture. This study assessed the prevalence and antimicrobial susceptibility of extended-spectrum beta- lactamase-producing Escherichia coli (ESBL-EC) in poultry and hand swabs of meat handlers working in a dressing plant in the Philippines. Fourteen (14) hand swabs from poultry handlers and 89 poultry cecal samples were collected and screened for ESBL production using MacConkey agar supplemented with cefotaxime and eosin methylene blue agar. Identification of E. coli through biochemical testing and antimicrobial susceptibility testing was then performed using the VITEK 2 System. Results showed that 7.14% (1/14) of the hand swabs and 23.60% (21/89) of the poultry cecal samples were positive for ESBL-EC. Identified isolates were further evaluated for their antimicrobial susceptibility using 33 antibiotics from various groups. Results showed 100% (22/22) resistance to the following antimicrobial drugs: ampicillin, ticarcillin, cefalotin, cefuroxime, cefuroxime axetil, cefixime, cefotaxime, nalidixic acid, ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, tetracycline, trimethoprim, and trimethoprim/ sulfamethoxazole. Resistance of select ESBL-EC isolates against other drugs under the beta-lactam, tetracycline, chloramphenicol, and aminoglycoside groups were also observed. Antimicrobial-resistant bacteria may be found in both human and animal sources, which highlights the need for ensuring safety practices to prevent their spread in the community. Gene sequencing and phylogenetic analysis may be used to further evaluate this relationship. Continuous surveillance and review of standards and protocols are also needed to monitor antimicrobial resistance, as underlined by the strategies of the One Health approach.
Determination of Phytase-hydrolyzable Phosphorus in Selected Animal Feed Ingredients by In Vitro Digestion Method
Authors: Canceran Nikkaela Mae , Angeles Amado
Published: September 2024

Feed phytase is one of the most successful biotechnological applications that led to better farm performance and effective phosphorus (P) reduction in animal excrement. Better estimation of phytase-hydrolyzable P (PHP) in feeds can further improve the estimation of animal rations for higher productivity. PHP in yellow corn, feed wheat, wheat pollard, rice bran, soybean meal, copra meal, and monodicalcium phosphate (MDCP) was determined by in vitro digestion. To determine if PHP values of feed ingredients are additive, three formulated diets were also subjected to the same method. The procedure consisted of phytase, pepsin, and pancreatin digestion periods – each of which simulated the different sections of poultry’s gastrointestinal tract. After these three incubations, the P contents in the dialysate and residual fluids – with and without enzyme – were analyzed. Results showed that yellow corn contained the highest PHP value with 52.54% of its total soluble P – followed by soybean meal, rice bran, copra meal, and feed wheat with 52.32, 39.86, 26.77, and 21.9%, respectively. Wheat pollard and MDCP had –58.47 and –2.63%, respectively. On the other hand, formulated diets 1, 2, and 3 contained actual PHPs of 32.3, 14.02, and 38.68% – as well as calculated values of 33.22, 29.13, and 40.1%, respectively. Statistical analyses showed no significant difference between the actual and calculated values. Therefore, PHP is additive when used in diet formulation. Lastly, comparing the P in the dialysate from the experiment and the available P present in the seven feed samples based on literature indicated that the experimental values were lower than those of the literature data for all samples. This discrepancy can be attributed to the type of samples analyzed; the experimental data were obtained upon in vitro assay of individual feeds, whereas the literature values were based on an as-fed basis, which may contain other components normally fed to animals.
Effectiveness of Nanoformulated Plant Growth Regulators in the Production and Propagation of High-value Crops and Ornamentals
Authors: Fernando Lilia , Parami Juan Miguel , Bautista Herald Nygel , Lopez Ida Allen , Mendoza David Joram , Atienza-Parcon Ma. Theresa Jonna , Magdalita Pablito , Fornoles Cyrus Ariel , Delfin Evelyn , Paterno Erlinda , Merca Florinia
Published: September 2024

Among the major classes of plant hormones, auxins, gibberellins, and cytokinins are widely used for plant propagation. These hormones influence the physiological and developmental processes of plants such as root initiation, apical dominance, seed germination, leaf expansion, and development of buds, flowers, and fruits. Its exogenous application was found to significantly improve the growth of several important plants. This study aimed to determine the effectiveness of plant growth regulators (PGRs) derived from naturally occurring plant growth-promoting bacteria (PGPBs) in the production and propagation of selected crops. In this study, indole- 3-acetic acid (IAA) and gibberellic acid (GA) were extracted from naturally occurring PGPB Bacillus sp. The extracted hormone was nanoformulated for controlled release and increased uptake in plants. The nanoformulated hormones were applied in the propagation of coffee and the production of eggplant and ornamentals. Results showed that the application of nanoformulated IAA (Nano-IAA) significantly increased the survival rate of coffee compared to the commercially available auxin. Nano-IAA increased the germination rate of eggplant in acidic soil and root emergence of Bougainvillea over the negative control (water) but was comparable to that of the commercially available auxin. The nanoformulated GAs and commercially available
Waste Reduction and Bioconversion of Quail, Chicken, and Pig Manure by Black Soldier Fly (Hermetia illucens L.)
Authors: Diola Clayton Sprewel , Nacilla Elaisa Jean , Pardillo Charm Angel , Alosbaños Ruby Sasha , Evacitas Florence , Maglangit Fleurdeliz
Published: September 2024

The increasing poultry and livestock farm operations have led to a great deal of manure generation. If inappropriately managed, it may cause adverse impacts on the environment, health, and economy. Black soldier fly (Hermetia illucens L.) larvae (BSFL) can potentially convert manure into protein-rich biomass and nutrient-rich frass effectively. In this study, BSFL were reared on three different waste streams – quail manure (QM), chicken manure (CM), and pig manure (PM). Manure mass was significantly reduced by larvae, of which QM had the highest overall degradation of 62.49% and waste reduction index of 10.42% (p-value < 0.05) of dry matter (DM). The larvae reared in QM also had the highest bioconversion rate (26.41%) and individual larval weight (~ 0.22 g/larva) (p < 0.05) with DM protein and fat contents of 54.77 and 13.79%, respectively, being a potentially high protein and high energy animal feed. Meanwhile, larvae reared in CM produced the lowest larval biomass (~ 0.07 g/larva) but had the most frass (252.10 g) (p < 0.05). However, there were no significant differences in the frass composition (organic matter, nitrogen-phosphorus-potassium, and carbon-to-nitrogen ratio) from the three substrates (p > 0.05). Therefore, BSFL presents a promising solution for efficient manure management by converting it into valuable frass and larval biomass with potential applications as plant fertilizer and animal feed ingredient, respectively.
Basic Morphology and Morphometry of Lake Danao in Ormoc City, Leyte, the Philippines
Authors: de la Cruz John , Romero Jeremy , Amistoso Allan Fritz Gerald , Romero II Victor , Lama Mark , Dañal Rhea Mae , Gerona-Daga Maria Elisa , Tabornal Racquel
Published: September 2024

Information on the morphology and morphometrics of Lake Danao – an integral part of the Lake Danao Natural Park in Ormoc City, Leyte, the Philippines – is incomplete and obsolete, which necessitates validation and updating. To address this gap, GIS, ground truthing, and bathymetric surveys using modern methods and technology alongside classical computing approaches were conducted in July 2022 to verify the accuracy and provide supplementary information to the lake’s existing basic morphometrics compiled from various sources. The results revealed a maximum length of 2,962 m, a maximum width of 825 m, and a shoreline length of 8.23 km. The relative depth (6.43%) and basin permanence index (6.83) demonstrated the lake’s extensive depth (maximum = 85.8 m). Using the frustum volume formula, Lake Danao is estimated to hold a maximum of ~ 56,214,143.56 m3 of water. The calculated surface area is 1,398,300 m2, 5.4% smaller than the previously published area of 1,480,000 m2 by NAMRIA in 1956. Additional studies are needed to confirm if this discrepancy is due to limitations in previous mapping techniques or indicative of actual area shrinkage. Local authorities can use these findings to update Lake Danao’s basic morphology and morphometrics information and conduct further research. However, cautious application of the results is necessary when drafting conservation and management strategies for the sustainable development of the protected area.
Das inklusive Potenzial auditiven Lesens
Authors: Schulz Miklas
Published: September 2024

Die fortschreitende Digitalisierung ermöglicht interessante Lesepraktiken, die sich vom klassischen visuellen Lesen unterscheiden. Computergestützte Sprachausgaben, die einst Menschen mit Sehbeeinträchtigungen vorbehalten waren, gehören zunehmend zum Alltag vieler Personen. Der Beitrag untersucht den Status des maschinell gesprochenen Wortes und beschreibt, wie diese gesprochene Schrift angeeignet wird. Auch in der Inklusionspädagogik bieten Screenreader-Programme neue Möglichkeiten. Dieses medientechnische Angebot lässt sich durchaus für eine grössere Zielgruppe im Unterricht nutzen, um eine individuelle und differenzierte Förderung zu ermöglichen.
The Relationship Between Mortality and Leuko-Glycemic Index in Coronary Care Unit Patients (MORCOR-TURK LGI)
Authors: Karakayalı Muammer , Kılıç Oğuz , Şahin Mürsel , Kelesoglu Saban , Yilmaz İshak , Duz Ramazan , Yılmaz Ahmet Seyda , Ersoy İbrahim
Published: September 2024

Introduction&Objective: Identifying high-risk patients with a poor prognosis in coronary care unit (CCU) patients can assist physicians in providing optimal care and implementing preventive strategies. Leuko-glycaemic index (LGI), synthesized by multiplying the blood glucose level by the leukocyte count, has gained popularity in risk stratification of myocardial infarction patients. In this context, this study was carried out to investigate the relationship between LGI assessed at admission and in-hospital mortality in CCU patients.
Methods: This is a multi-center, cross-sectional and observational study. (MORCOR-TURK LGI: Mortality Predictors in Coronary Care in Turkey, ClinicalTrials.gov number NCT05296694). The population of this study consisted of 2917 consecutive patients admitted to the CCU. Blood samples were collected into serum separator tubes in the immediate admission to the CCU. LGI was calculated by multiplying both values and dividing them by a thousand. LGI units were expressed in mg/dl. mm³. The sample was divided into two groups based on the LGI cut-off value of 1.23. Logistic regression analysis was used to find the significant predictors of mortality. Receiver operating characteristics (ROC) curve was to find out the cut-off value of LGI. A p value less than 0.05 was considered to be statistically significant in all analyses.
Results: Univariable logistic regression analysis revealed that age, heart failure (HF), LGI, coronary artery disease, hypertension, diabetes mellitus and atrial fibrillation are clinically and statistically significant predictors. Further analysis of these variables using the multivariable logistic regression analysis indicated that age (Odds Ratio [OR]: 1.040, 95% confidence interval [CI]: 1.017-1.063; p=0.001), HF (OR: 2.426, 95% CI: 1.419-4.149; p:0.001) and LGI (OR: 1.349, 95% CI: 1.176-1.549; p3.72 predicted in-CCU mortality with 95.56% sensitivity and 49.19% specificity ([AUC]: 0.659 [95% CI: 0.641–0.676, p
Retrospective Evaluation of Patients Diagnosed with Brain Death in the Intensive Care Unit: A 10-year Single Center Analysis
Authors: Uluç Kamuran
Published: September 2024

Aim: This study aimed to investigate the demographic characteristics, clinical features, timing of the diagnosis of brain death, and factors associated with organ donation in patients diagnosed as brain dead in the intensive care unit in the last decade.
Method: Between 01.01.2015-01.06.2024, the age, gender, intensive care unit hospitalization diagnoses, the day of intensive care unit hospitalization, blood groups, the number of patients diagnosed with brain death by years, the number of patients diagnosed with brain death, the number of patients who became donors, laboratory values on the day of intensive care unit hospitalization and the day of brain death diagnosis, the reasons why families did not accept organ donation were recorded from the patients' files and hospital information system.
Results: A total of 59 patients were included in the study. Of the patients, 32 (54.24%) were female and 27 (45.76%) were male. The age distribution of the patients was seven (11.86%) aged 0-17 years, 29 (49.15%) aged 18-64 years, and 23 (38.98%) aged 65 years and older. The most common intensive care unit hospitalization diagnoses were intracerebral hemorrhage (35.59%), subarachnoid hemorrhage (16.95%), and CVA (13.56%). Although brain death was diagnosed in 83.05% of the patients in the first seven days, it was diagnosed in an average of 4.81 days in all patients. When the laboratory values between the day of admission to the intensive care unit and the day of brain death were diagnosed, a statistically significant difference was found in Na+, Cl-, K+, AST, BUN, and creatinine values (p0.05). Among the reasons for not accepting organ donation, familial reasons were the highest, with 79.66%.
Conclusion: In order to increase the number of organ donations, it is important to raise public awareness and increase the level of knowledge of families about organ donation. Patients with poor neurological prognosis with hospitalization diagnoses such as intracranial hemorrhage, CVA, and Post CPR should be closely monitored for brain death and potential donors.
Effectiveness and Results of the Laparoscopic Total Extraperitoneal Repair (Tep) Method Applied in Inguinal Hernia Surgery: 10 Years of Experience
Authors: Sakoğlu Nevin , Gök Mehmet Ali , Civil Osman
Published: September 2024

Objective: Laparoscopic Total Extraperitoneal (TEP) hernia repair is frequently performed around the world. Ourgoal here was to evaluate preoperative radiologic findings, intraoperative and postoperative conditions of cases, together with their demographic characteristics, in unilateral, bilateral primary and recurrent cases undergoing hernia operation.
Methods: Between 2011 and 2021, 512 patients were operated for hernia with laparoscopic TEP method. Age, gender, BMI, hernia type, radiologic or peroperative type of hernia, defect size measured during surgery, hernia side, content of hernia, postoperative complications(seroma) of these patients were evaluated retrospectively. Additionally to the expressive statistical procedures (mean, standard deviation) in interpriting and calculating the input, the allocations of the variables were analyzed by the Shapiro-Wilk normality test. Also the independent t test, chisquare test, and logistic regression analysis used. The outcome spicked up were analyzed with p
Impact of high triglyceride/high-density lipoprotein cholesterol ratio in non-st segment elevation myocardial infarction
Authors: Akkaya Süleyman , Özen Kaya
Published: September 2024

Introductıon: Globally, cardiovascular disease (CVD) is the leading cause of death. Among these risk factors, dyslipidemia, hypertension, and diabetes mellitus (DM) are significant pathological disorders that lead to this illness. In addition to being a risk factor for cardiovascular disease, insulin resistance is a prevalent characteristic of metabolic syndrome, obesity, and diabetes mellitus. It has been demonstrated that the triglyceride/HDL ratio is a valid indicator of insulin resistance.
In this study, we tried to emphasize the criticality of early intervention in NSTEMI patients by revealing whether the TG/HDL ratio indicating insulin resistance is different between NSTEMI and ST elevation myocardial infarction (STEMI) patients.
Methods: Patients admitted to a training and research hospital with a prediagnosis of acute coronary syndrome and diagnosed as having NSTEMI or STEMI were included in the study. Our study included 113 NSTEMI and 166 STEMI patients.
Results: In NSTEMI patients, the mean HDL value was 39 (25-65) mg/dl, the mean LDL value was 105 (29-244) mg/dl, the mean T. cholesterol value was 180 (78-356) mg/dl, and the mean triglyceride value was 136 (37-360) mg/dl. When NSTEMI patients were compared with STEMI patients in terms of TG/HDL ratio, NSTEMI patients were significantly higher. (p:0.027; p
Evaluation of Coagulation Disorders in Intubated and Non-Intubated Patients with Covid-19 Diagnosis in The Intensive Care unit
Authors: Aydin Yunus Emre , Karakuş Abdullah , Aydın Emre , Yılmaz Aydın Fatma , Tekin Recep , Kuyumcu Mahir , Kadiroğlu Ali Kemal
Published: September 2024

Objective: It is known that the need for invasive mechanical ventilation due to severe respiratory failure develops in COVID-19 patients followed in the intensive care unit. It has been reported in the literature that coagulopathy seen during COVID-19 disease is an important cause of mortality and morbidity. Our aim in our study was to evaluate coagulation disorders developing between intubated and non-intubated patients.
Method: The data of 812 patients diagnosed with COVID-19 in the Intensive Care Unit, between March 2020 and September 2021 were retrospectively analyzed. The patients were divided into two groups according to the need for invasive mechanical ventilation. Demographic characteristics, laboratory values at the time of diagnosis, coagulopathy development status and survival of the patients were investigated.
Results: Of the 812 patients included in the study, 459 (56.5%) were male. The mean age was 66,4 ± 15,2. 257 (31.7%) of the patients received invasive mechanical ventilation support. Coagulopathy was detected in 146 (56.8%) of these patients. Distribution of coagulopathy in intubated patients; 26% Disseminated Intravascular Coagulation, 17.9% Acute Coronary Syndrome, 10.5% Hemorrhage (inside or outside the body), 5.4% Pulmonary Embolism, 5% Heparin-Induced Thrombocytopenia, 3.5% Ischemic Stroke, 1.9% Hemorrhagic Stroke and 0.8% found as Deep Vein Thrombosis. We found that 32% of the patients who were not intubated developed coagulopathy, and this difference was statistically significant (p
Evaluation of Shunt-Related Ventriculitis in Infants
Authors: Arpa Abdurrahman , Aydın Ozturk Pınar , Asena Muhammet
Published: September 2024

Aims: Shunt-related infections are resistant to antibiotics. This study examined patients aged under two years after ventriculitis. It is the first study on ventriculitis developed in a completely closed system (without skin defect infection, or puncture history), evaluating infants only.
Method: The study included 13 subjects (four females) with ventriculitis who had undergone surgery for hydrocephalus during the neonatal period and were monitored for shunt infection, evaluating certain parameters.
Results: Ventriculitis developed on an average of 2.8 months after surgery. The most common causes of hydrocephalus were spina bifida and intraventricular hemorrhage. Bacteria grown in culture included Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens. Seven (53.8%) patients were treated without complications. Among other patients, three (23.1%) developed multilocular cystic hydrocephalus and three (23.1%) exhibited decreased cerebrospinal fluid production and did not require shunting.
Conclusions: Patients receiving intraventricular therapy showed no complications, warranting further studies on early intraventricular therapy. In the presence of gram-negative bacterial growth, cerebrospinal fluid production may decrease and affected patients do not require shunts.
Evaluation of Probiotic Use in Children With and Without Allergic Diseases
Authors: Büyük Yaytokgil Şule , Vezir Emine
Published: September 2024

Aim: Various studies have reported that probiotics play a role in immune modulation and in preventing the development of allergic diseases by affecting the intestinal flora. However, there is no clear consensus on this subject yet. This study aimed to evaluate the usage of probiotics in children with and without allergic diseases.
Method: Probiotic usage of children (
Asistan Hekimlerde Stresle Başa Çıkma Tarzları ve Mesleki Doyum Düzeylerinin Değerlendirilmesi
Authors: Bal Nilay Gül , Orhan Özlem , Doğaner Adem
Published: September 2024

Amaç: Ülkemizde asistan hekimlerin, uzmanlık eğitimi sürecinde ağır iş yükü ve önemli zorluklarla karşı karşıya kaldığı bilinmektedir. Bu durumun asistan hekimlerde stres ve mesleki doyum düzeylerini etkileyebileceği, ruhsal ve bedensel yakınmalara sebep olabileceği düşünülmektedir. Bu çalışmanın amacı, asistan hekimlerde stresle başa çıkma tarzları ve mesleki doyum düzeylerini değerlendirmenin yanısıra asistan hekimlerin mevcut ruhsal belirtilerini araştırmaktır.
Yöntemler: Araştırmaya dahil edilme kriterlerini karşılayan toplam 174 asistan hekim katıldı. Katılımcılara Sosyodemografik Veri Formu, Stresle Başa Çıkma Tarzları Ölçeği, Mesleki Doyum Ölçeği, Eysenck Kişilik Anketi ve Belirti Tarama Ölçeği (SCL-90-R)uygulandı.
Bulgular: Çalışmamızda asistan hekimlerde stresle başa çıkma tarzları arasında en sık kullanılan yöntemin kendine güvenli yaklaşım olduğu bulunmuştur. İyimser yaklaşım tarzı ve mesleki doyum düzeyleri; erkek, 30 ve üzeri yaştaki hekimlerde, kıdemli asistan hekimlerde anlamlı derecede yüksek çıkmıştır. Çaresiz yaklaşım tarzı, asistanlık süresi 18 ay ve altı olan asistan hekimlerde daha fazla tespit edilmiştir. Stresle başa çıkma tarzları ve mesleki doyum düzeyleri arasında anlamlı ilişki bulunamamıştır. Ruhsal belirti dağılımına bakıldığında en yüksek puanların sırasıyla obsesif kompulsif belirti, kişilerarası duyarlılık ve depresyon alt kategorilerine ait olduğu, kadın hekimlerde depresyonun, erkek hekimlerde kişilerarası duyarlılığın en sık görülen ruhsal belirti olduğu saptanmıştır. Tüm ruhsal belirtiler, kendine güvenli yaklaşım ve iyimser yaklaşım ile negatif yönlü, çaresiz yaklaşım ile pozitif yönlü anlamlı bir ilişki göstermiştir. Branşlar arasında stresle başa çıkma tarzları, mesleki doyum düzeyleri ve ruhsal belirti dağılımı açısından anlamlı farklılık olmadığı saptanmıştır.
Sonuç: Asistan hekimlerde stres düzeylerini azaltacak ve mesleki doyum düzeylerini artıracak müdahaleler (daha iyi çalışma koşulları oluşturulması, yoğun iş yükünün azaltılması, bilgi ve tecrübeyi arttıracak çalışma motivasyonunu yükseltecek imkanlar sunulması vb.) hekimlerin ruhsal bedensel iyilik hali ve topluma daha nitelikli hizmet sunmaları açısından önemlidir.
Ensefalit Tanılı Hastalarda Ampirik Asiklovir Kullanımında Akut Böbrek Yetmezliği Gelişimi ve Mortalite ile ilişkisi
Authors: Güven Münevver Ece , Tekan Ülgen Yalaz , Cerrahoğlu Şirin Tuba , Necioğlu Örken Dilek
Published: September 2024

Giriş ve Amaç: Herpes simpleks virüs ensefaliti (HSVE), enfeksiyöz ensefalitlerin en yaygın nedeni olup, tanı ve tedavide gecikme kötü prognozla ilişkilidir. İntravenöz (IV) asiklovir kullanımına bağlı gelişebilecek renal toksisite tedavi kararı verilirken akılda tutulmalıdır. Bu çalışmada, IV asiklovir tedavisi alan hastalarda akut böbrek yetmezliği (ABY) gelişimi üzerine etki eden faktörlerin incelenmesi ve ABY gelişiminin mortalite üzerine etkisinin araştırılması amaçlanmıştır.
Yöntemler: Hastanemize akut konfüzyonel durum nedeniyle başvuran ve viral ensefalit ön tanısı ile ampirik IV asiklovir tedavisi başlanan hastaların demografik ve klinik verileri retrospektif olarak incelendi. Hastaların nörolojik muayene, kranial manyetik rezonans görüntüleme (MRG), beyin omurilik sıvısı (BOS) ve elektroensefalografi bulguları ile asiklovir tedavi süreleri kaydedildi. Tanıda, Uluslararası Ensefalit Konsorsiyum Kriterleri baz alındı. ABY, 48 saat içinde serum kreatininde ≥%50 ya da >0.3 mg/dl artış olarak tanımlandı.
Bulgular: Çalışmamıza dahil edilme kriterlerini karşılayan 29 hastanın 16’sı (%55) erkek ve ortanca (min-maks) yaş 58 (20-89) idi. Tüm hastalar değişen sürelerde (min-maks= 3-21 gün), ortalama 11±6 gün IV asiklovir tedavisi aldı. Bu hastaların %20,7’sinde MRG ve/veya BOS bulgularıyla viral ensefalit tanısı kesinleştirildi. On bir hastada (%37,9) yatışının bir döneminde ABY gelişti. Hipertansiyon mevcudiyetinin ABY gelişimini arttırdığı görüldü (p=0,01). ABY gelişen hastaların asiklovir tedavi süresi gelişmeyenlerden kısaydı (p
Pengembangan Bahan Ajar Cerita Rakyat Tana Luwu Terintegrasi Pendidikan Karakter di Sekolah Dasar
Authors: Wahyuni Dian , Nursyamsi Nursyamsi , Firman Firman
Published: September 2024

This research aimed to develop an innovative Printed Teaching Material (Module) based on Tanah Luwu folktales that meets the needs of students in Sekolah Dasar Negeri (SDN) 657 Passampa Kab. Luwu Sulawesi Selatan. The findings indicate that the development of teaching materials grounded in folktales can enhance the quality of education and students' critical thinking skills. The validity and practicality of the developed teaching materials have been confirmed by experts, teachers, and students, with overwhelmingly positive feedback. The implications of this research emphasize the importance of integrating folktales into education as a strategy to preserve culture and increase the appeal of learning. The study also encourages the development and application of folktale-based teaching materials in school curricula, which can assist teachers in creating more interactive and meaningful learning experiences for students. Overall, this research provides a significant contribution to improving the quality of education in Indonesia by promoting a more contextual and innovative approach to learning.
NATO ÜYELİĞİNDEN ÖNCE VE SONRA SLOVAKYA'NIN GÜVENLİK VE SAVUNMA İKİLEMİ- CSDP (ORTAK GÜVENLİK VE SAVUNMA POLİTİKASI) KAPSAMINDA YENİ BİR KİMLİK NASIL İNŞA EDİLDİ?
Authors: Alhilmee Zahraa Ghazi
Published: September 2024

Soğuk Savaş Dönemi ardından Sovyetler Birliğinin dağılmasıyla, bu ülkeden ayrılan Doğu Avrupa ülkeleri büyük bir dönüşümü yaşamış ve güvenlik ve ekonomik kaygılarının bir sonucu olarak Avrupa Birliği ve NATO’ya üye olmak istemişlerdir. Bunun altında yatan ana neden böylece arzu ettikleri güven ve huzura bir an önce kavuşmak istemeleriydi. Ancak zaman içinde bu konuda hemen sonuç alamayacaklarını ve bu suretle endişelerini gidermelerinin mümkün olmadığını anlamakta gecikmediler. Ne NATO ne de Avrupa Birliği güvenlik endişelerini gidermediği gibi savunma harcamalarını daha da artırmak zorunda kaldıkları herkes tarafından görüldü. Bu ülkelerden birisi de şüphesiz Slovakya olmuştu.
Kimlik inşası; kimlikler üzerinden yaşanan, ötekileştirme, birleştirme, bütünleştirme, gelişme, ayrıştırma ya da çözülme gibi süreçleri açıklayan bir kavram olarak açıklanmaktadır. Kimlik inşası diğer yandan var olma süreçlerinin ayrılmaz bir parçasıdır ve kültürel birikimle şekillenen kimlik, benzeşmenin, kaynaşmanın veya çözülmenin alanı olarak hem bir araya getirici hem de ayrıştırıcı bir özelliğe sahiptir.
Bu makalede bir Doğu Avrupa ülkesi olan Slovakya’nın NATO üyeliği öncesi ve sonrasına odaklanılarak, Avrupa Ortak Güvenlik ve Savunma Politikası kapsamında yeni bir kimlik inşasını nasıl inşa etmeye çalıştığı ve bu doğrultuda güvenlik ve savunma alanında yaşadığı güvenlik ikilemleri açık kaynaklardan elde edilen bilgiler ışığında incelenecek ve bu ülkelerin yaşadıkları sıkıntılara ve bir türlü ulaşamadıkları güvenlik ihtiyacına literatür taraması ile bilimsel bir açıklama getirilmeye çalışılacaktır.
Araştırma genel olarak Slovakya ve yakın çevresinde bir oranda da Vişegrad ülkeleri esas alınarak sürdürülmüştür. Şüphesiz aynı sıkıntının diğer Doğu Avrupa ülkelerinde de az ya da çok yaşandığı görülmektedir. Yapılan araştırma, aynı zamanda bu bölgelerde güvenlik ihtiyacının giderilmesine yönelik daha gerçekçi bir yapılanmanın nasıl olması gerektiği konusu üzerinde de bazı önerileri ortaya koyacaktır.
Ayurveda Inspired Discovery of Oral Anti-Cancer Drugs
Authors: Nag Bishwajit , Agarwal Rupali , Sen Ananda , Srinivasan Narasimhan
Published: September 2024

This review discusses the vast knowledge of natural products with strong emphasis on Ayurveda linked active ingredients for the treatment and management of cancer. RENOVEL uses an approach to integrate these resources and create a new class of orally active drugs for cancer research. Over the last decade, our lab has provided significant stimuli towards developing new class of drugs for major health conditions with multiple ongoing clinical trials. In this review we are extending our core technology towards discovery and development of Ayurveda-based new lead molecules for cancer treatment and management. Significant progress on cancer research has evolved over the last 50 years. Initial studies discovered altered pathways in normal cell division leading to cancer and developed specific drugs for each targeted pathway. Further research has unfolded increasingly more complex layers of regulation of cancer cells by the tissue microenvironment, the extracellular matrix, and the surrounding stroma including fibroblasts and immune cells and the gut microbiome. Mental stress, environmental factors, and genetics also have a major role in the development of cancer. Ayurvedic principles outline even more complex levels of regulation on how the cells and tissues interact with and are influenced by the mind, body and environmental factors. Documented clinical trials for cancer treatment with drugs of Ayurvedic origin are limited. The US National Institutes of Health site, Clinical Trials.gov, lists 50 clinical trials (2000–2023) for ―Ayurveda‖ for multiple disease conditions but only a few are for cancer. These trials are mostly conducted in India, Germany, UK, and a few in the USA. Many Ayurvedic active ingredients have been implicated for ameliorating cancer. It is widely acknowledged that these herbal ingredients deliver bodily homeostasis and suppress the proliferation of tumors. Taking these in consideration along with SAR and bioinformatics, RENOVEL Innovation has synthesized over 40 new Ayurveda-based anti-cancer molecules which are currently in preclinical development. These molecules were screened in 15 human cancer cell lines spanning over 5 major cancer types. In this review, a full overview of growing concern in rapid increase in global cancer with existing drugs, biologics and customized products are discussed along with Ayurveda inspired anti-cancer lead molecule development by RENOVEL.
Management and Treatment of Cancer and Diabetes: A Common Corridor
Authors: Kumar Lal Narendra
Published: September 2024

The escalating global prevalence of cancer and diabetes underscores the need for proactive prevention and management strategies. With nearly 20 million new cancer cases reported in 2022, and India facing a significant public health challenge with 1.46 million new cases, urgent attention is required. Diabetes, affecting over 450 million globally, sees a 13% rise in mortality rates in lower middle-income countries from 2000 to 2019. The coexistence of cancer and diabetes in 8- 18% of patients poses treatment challenges and elevates mortality risks. Shared risk factors, including obesity, genetics, inflammation, and unhealthy lifestyles, contribute to heightened risks, emphasizing the importance of lifestyle modifications. The complex link between cancer and diabetes involves mechanisms such as hyperglycemia, insulin resistance, and elevated insulin levels. Cancer treatments may impact blood sugar levels, necessitating close monitoring and potential adjustments to diabetes medications. While concerns arise about cancer risks associated with diabetes therapies like insulin and sulfonylureas, metformin shows potential protective effects. Managing cancer patients with diabetes requires a collaborative, multidisciplinary approach, incorporating regular blood glucose monitoring, individualized treatment plans, nutritional support, exercise, and cautious steroid use. Emphasizing prevention, early detection, and supportive care, along with patient education and empowerment, is crucial. Regular follow- ups and, in some cases, palliative care contributes to a comprehensive strategy to enhance the quality of life for those navigating both cancer and diabetes.
A Perspective on Recent Trends in Diabetes and its Cure
Authors: Saxena Pragati
Published: September 2024

This chapter provides an in-depth exploration of recent trends in diabetes research and treatment, offering a comprehensive perspective on the multifaceted strategies aimed at understanding, monitoring, and managing this global health challenge. The molecular intricacies of diabetes are elucidated through advances in genetic profiling, epigenetics, and environmental factors, shaping a foundation for targeted and personalized therapeutic interventions. Innovations in diabetes monitoring, particularly continuous glucose monitoring (CGM) technologies, coupled with artificial intelligence and predictive analytics, usher in a new era of real-time, proactive management. Emerging therapeutic approaches, ranging from gene therapy to immunomodulation and metabolic surgery, present promising avenues toward potential cures. The paradigm of personalized medicine takes center stage, integrating genetic insights, biomarkers, and digital health technologies to tailor interventions to individual characteristics. The conclusion reflects on the transformative impact of recent trends, acknowledging challenges, and emphasizes the ongoing global collaboration essential for realizing the promise of a healthier, more equitable future in the realm of diabetes.
Pengaruh Interaksi Sosial terhadap Kemampuan Emosi Anak Usia Dini di Raudhatul Athfal Tunas Kualuh Kecamatan Kualuh Hilir Kabupaten Labuhanbatu Utara
Authors: Daulay Maulida Rahmah , Hasibuan Humaidah Br. , Nasution Raisah Armayanti
Published: September 2024

This study aims to determine the effect of social interaction on the emotional abilities of early childhood in Raudhatul Athfal Tunas Kualuh, Kualuh Hilir District, North Labuhanbatu Regency and identify the effect of social interaction on children's emotional abilities.  This type of research is descriptive quantitative research, the population in this study involved 30 respondents and respondents using instruments that were tested for validity and reliability of sampling techniques using probability techniques, data collection instruments using observation and documentation. As for the formulation of the problem, namely how is the social interaction of children in RA Tunas Kualuh, how is the emotional ability of children in RA Tunas Kualuh, and is there an influence of social interaction on children's emotional abilities in RA Tunas Kualuh? The data analysis techniques used are normality test, and homogeneity test and hypothesis test (T test). Based on the results of the study that the validity test shows that the instruments for social interaction variables (X1) and emotional abilities (Y2) are valid and reliable. Normality test with Kolmogorov-Smirnov shows that the data is normally distributed (Asymp.Sig. = 0.370). The homogeneity test showed that the variance between groups was homogeneous (Sig = 0.517). The results of the hypothesis test (T test) indicated that social interaction has a significant influence on children's emotional abilities (Sig = 0.000), with a Beta coefficient of -0.723. This study concluded that social interaction plays a significant role in influencing children's emotional abilities in RA Tunas Kualuh, with the instruments used being valid and reliable. Thus Ho is rejected and Ha is accepted that social interaction does have a significant influence on children's emotional abilities.