bluuebunny/crossref_metadata_2025 huggingface dataset:
Interim remedies and constitutional rights
Authors: Sharpe Robert J
Published: December 2019

Interim remedies are granted before the court has been able to come to a final determination of the issues raised by the case. Canadian courts are reluctant to grant interim remedies that would restrain the application of a constitutionally challenged law. Ordinarily, the public interest in the orderly administration of duly enacted laws has been found to prevail over the claimant’s right to interim protection of a claimed constitutional right. This article examines the reasons used to justify this cautious approach and argues that it is not entirely consistent with the Charter’s promise of effective remedies. The rule limiting consideration of the merits of the claim on interim applications should be relaxed, especially where refusing an interim remedy will cause the immediate and irretrievable loss of a constitutional right. This would bring Canadian law into line with English, American and international law and would better protect fundamental rights and freedoms. Greater use should be made of interim remedies that exempt litigants from constitutionally challenged laws rather than suspend the operation of the law entirely.
Stress analysis of a Wankel engine eccentric shaft under varied thermal conditions
Authors: Cihan Ömer , Bulut Mehmet , Kutlar Osman Akın
Published: December 2019

In this study, the eccentric shaft of a 13B MSP (Multi Side Port) single-rotor Wankel test engine was examined. The eccentric shaft was studied in two parts, both through modeling and experimentally. The eccentric shaft was modeled via a workbench module using ANSYS software. Here, the shaft was modeled according to the original dimensions at different speeds ranging from 1000 to 10000 rpm under different operating temperatures (25, 50 and 90 °C). In the analysis, von Mises stress and corresponding deformations were examined under the specified conditions. Afterwards, the stress and deformation of the eccentric shaft were experimentally investigated in engine tests performed at low loads and speeds. The eccentric shaft broke after approximately 200 hours. It was found that broken region was specified to critical points for validity of the applied model used in the current study. Thus, it was shown deformation and stress values can be predicted by numerically modeling the eccentric shaft with the help of ANSYS software in order to determine whether the eccentric shaft can withstand external loading under various conditions.
UNWEARABLE MULTI-MODAL GESTURES RECOGNITION SYSTEM FOR INTERACTION WITH MOBILE DEVICES IN UNEXPECTED SITUATIONS
Authors: Elleuch Hanene , Wali Ali
Published: December 2019

In this paper, a novel real-time system to control mobile devices, in unexpected situations like driving, cooking and practicing sports, based on eyes and hand gestures is proposed. The originality of the proposed system is that it uses a real-time video streaming captured by the front-facing camera of the device. To this end, three principal modules are charged to recognize eyes gestures, hand gestures and the fusion of these motions. Four contributions are presented in this paper. First, the proposition of the fuzzy inference system in the purpose of determination of eyes gestures. Second, a new database has been collected that is used in the classification of open and closed hand gesture. Third, two descriptors have been combined to have boosted classifiers that can detect hands gestures based on Adaboost detector. Fourth, the eyes and hand gestures are erged to command the mobile devices based on the decision tree classifier. Different experiments were assessed to show that the proposed system is efficient and competitive with other existing systems by achieving a recall of 76.53%, 98 % and 99% for eyes gesture recognition, detection of fist gesture, detection of palm gesture respectively and a success rate of 88% for eyes and hands gestures correlation.

ABSTRAK:  Kajian ini mencadangkan satu sistem masa nyata bagi mengawal peranti mudah alih, dalam keadaan tak terjangka seperti sedang memandu, memasak dan bersukan, berdasarkan gerakan mata dan tangan. Kelainan sistem yang dicadangkan ini adalah ia menggunakan masa nyata video yang diambil daripada peranti kamera hadapan. Oleh itu, tiga modul utama ini telah ditugaskan bagi mengenal pasti isyarat mata, tangan dan gabungan kedua-dua gerakan. Empat sumbangan telah dibentangkan dalam kajian ini. Anggaran pertama bahawa isyarat gerak mata mempengaruhi sistem secara kabur. Kedua, pangkalan data baru telah dikumpulkan bagi pengelasan isyarat tangan terbuka dan tertutup. Ketiga, dua pemerihal data telah digabungkan bagi merangsangkan pengelasan yang dapat mengesan isyarat tangan berdasarkan pengesan Adaboost. Keempat, gerakan mata dan tangan telah digunakan bagi mengarah peranti mudah alih berdasarkan pengelasan carta keputusan. Eksperimen berbeza telah dijalankan bagi membuktikan bahawa sistem yang dicadang adalah berkesan dan berdaya saing dengan sistem sedia ada. Keputusan menunjukkan 76.53%, 98% dan 99% masing-masing telah dikesan pada pengesanan gerak isyarat mata, genggaman tangan dan tapak tangan, dengan kadar 88% berjaya mengesan gerak isyarat mata dan tangan.
Evaluation of The Effects of ELF-EMF on Oxidative Parameters in Brain, Liver and Heart Tissues
Authors: GÜLEÇ PEKER Emine Gülçeri , BALABANLI K. Barbaros , TOMRUK Arın , CANSEVEN KURŞUN A. Gülnihal , COŞKUN CEVHER Şule
Published: December 2019

The aim of the present study was to investigate the prospective effects of continuous and intermittent extremely low-frequency magnetic fields (ELF-EMFs) on the levels of malondialdehyde (MDA), nitric oxide (NO) and glutathione (GSH) in brain, heart, and liver tissues. The experiments performed on 18 guinea pigs were divided into three groups (n= 6 for each group). 50 Hz of 1.5 mT a magnetic field was used for exposure. Experimental groups were exposed for 4 h/day either continuously or intermittently (2h on/ 2h off/ 2h on) EMF for a period of 7 days. MDA, NO and GSH levels were determined by spectrophotometric methods. The intermittent exposure was increased GSH levels whereas that was reduced MDA levels in the brain when compared to control and continuous exposure groups. GSH concentrations of both experimental groups were found to be elevated in the liver. In the liver and heart, NO levels were increased by the continuous exposure in both administration groups, however, intermittent exposure has reduced NO levels in the both of the experimental groups.  Results of this study indicated that the responses of various tissues to magnetic field exposures differed according to intensity and exposure duration of magnetic fields.
Sifat-Sifat Pembakaran Bioetanol Gel Dari Buah Berenuk (Crescentia Cujete L.)
Authors: Nurkholis Nurkholis , Fajar Abdul , Rohman Sopyan Ali
Published: December 2019

Salah satu sumber bahan bakar nabati yang berpotensi misalnya adalah buah berenuk (crescentia cujete L.), karena mempunyai kandungan karbohidrat yang cukup tinggi yaitu 15,56% (wet basis) dan 68,13% (dry basis). Bioetanol cair dapat diubah menjadi gel dengan penambahan pengental yang mempunyai nilai ekonomis, misalnya carboxymethyl cellulose (CMC). Penelitian ini bertujuan untuk mengetahui sifat-sifat pembakaran gel etanol dari buah berenuk (crescentia cujete L.) menggunakan bahan pengental CMC yang dihasilkan, seperti: nilai kalor, dan uji pembakaran (laju pembakaran, nyala api dan residu hasil pembakaran), sehingga dapat diketahui formulasi terbaik untuk menghasilkan gel etanol. Pembuatan gel bioetanol dilakukan proses gelasi yaitu dengan mencampurkan bahan pengental CMC sebanyak 1, 2, dan 3 gram dengan 20 mL akuades, dan bioetanol cair sebanyak 100 g sedikit demi sedikit dengan pengadukan menggunakan magnetic stirrer selama 15 menit dengan kecepatan 600 rpm. Hasil penelitian menunjukkan bahwa sifat-sifat pembakaran terbaik adalah pada variasi berat (CMC) sebesar 3 gram dengan nilai kalor sebesar 2.334 kal/ gram, laju pembakaran 0,0369 gram/ detik dan residu pembakaran berkisar antara 45-47%.
P28-Fur-Grb, A Novel Fusion Protein with Enhanced Targeted Cytotoxicity Against Breast Cancer
Authors: Ranjbar Saeed , Momeni Aria , Reshadmanesh Azadeh , Fakhravar Azita , Paydarnia Nafiseh , Ranjbar Saeed
Published: December 2019

Targeting tumor cells via multiple pathways promises the emergence of a new era in cancer therapy.
Consisting of a cell-binding ligand and a cytotoxic moiety, cytolytic fusion proteins can selectively bind
and kill target cells with minimal adverse effects. We designed a novel immunoproapoptotic fusion protein,
p28-fur-GrB, composed of the cancer-specific azurin-derived cell penetrating peptide, p28, and a mutant
version of human serine protease granzyme B. The two moieties were genetically fused by a furin sensitive
linker, allowing in vivo cleavage and activation of the immunotoxin after cell entry. Synthesized coding
gene of the recombinant protein was cloned and expressed in HEK293T cells, and nickel chromatography
was applied for protein purification. After in vitro furin cleavage and primary analyses of SDS-PAGE,
Western blotting, GrB activity and ELISA binding assay, the fusion protein was tested for its cytotoxicity
on various breast cancer cell lines. Suppression of cell proliferation and viability was evaluated using the
WST-1 assay. Furthermore, DNA fragmentation was measured as an indication of apoptotic effects of the
fusion protein on treated cells. Based on our results, p28-fur-GrB was efficiently cleaved by furin and
showed high GrB activity and binding affinity after cleavage. Following 72h of incubation with IC50 values
of the fusion protein, significant cytotoxic effects of 80.6%, 77.1%, 74% and 69.6% were recorded for BT474, MCF7, SK-BR-3 and MDA-MB-231 tumor cells, respectively. Proliferative potential of MCF 10A
normal cells was not affected by the treatment. Analysis of the rate of apoptosis in treated cells confirmed
our cytotoxicity results. We concluded that p28-fur-GrB is a potent anti-tumor agent with high cytotoxicity
against breast cancer cells.
Management and Outcomes of Spontaneous Rupture of Hepatocellular Carcinoma: Current Practice
Authors: Mirza Ahmad , Mirza Ahmad , Pannu Arslan , Lawrence Eloise , Dar Ghulam Murtaza , Khan Khurram , Jabbar Salman , Ahmed Shahzad
Published: December 2019

Objectives: To review the current management options for ruptured hepatocellular carcinoma (HCC) at
acute presentation and assess the impact of each treatment modality on short- and long-term patient related
outcome.
Study design: A PubMed search was undertaken for review articles from 1950 to 2019 using key phrases
“Ruptured hepatocellular carcinoma”, “trans-arterial embolization”, “resection”, “computed tomographic
scan” and “conservative management”. Further manual search was performed to identify key articles from
the reference list.
Methodology: All papers with previous described management for ruptured HCC were reviewed. The
morbidity, mortality and comparison of various management options were reviewed. Current practice
guidelines were visited to identify common practice protocols.
Conclusion: Ruptured HCC is associated with significant morbidity and mortality. Multiple management
options can be applied guiding by patient’s overall condition. Conservative management is associated with
overall poor outcome. Staged liver resection is associated with better outcome with improved morbidity and
mortality.
Underestimating the Burden of Disease in Sarcomatoid Carcinoma of The Lung: A Case Report and Literature Review
Authors: Melstrom Laleh , Newman Indra M. , Kim Jae , Melstrom Laleh , D’Apuzzo Massimo , Wong Paul
Published: December 2019

Acute appendicitis is one of the most common emergency surgical procedure, yet atypical presentation
sometimes can be challenging for clinician. I present a case of 19-year-old gentleman that initially presented
with 1day history of bilateral testicular pain and lower abdominal pain. His past history includes a positive
sexual history. Initial ultrasound of the testis showed bilateral orchitis and an equivocal appendix. With a
significantly raised inflammatory marker and highly suspicious for appendicitis, a CT scan was obtained
which showed perforated appendicitis and the patient underwent laparoscopic appendicectomy with
resolution of symptoms after that. We encourage clinician to be aware of this clinical pitfall as patient can
sometimes be managed in other department to minimise any delayed diagnosis or any unnecessary
procedure
The Association of Fgf23 and Inflammation in Heart Failure with Normal Kidney Function
Authors: Koller Bernhard , H Ulmer , Koller Bernhard , J Dörler , M Dünser , W Grander , G Polzl , MM Zaruba
Published: December 2019

Background: Fibroblast growth factor-23 produced by osteocytes regulates calcium and phosphate
homeostasis which are cornerstones for bone integrity. Recently, FGF23 was also found to be directly
related with both severity and prognosis of heart failure. However, the mechanism of FGF23 regulation in
heart failure, particularly in patients with preserved renal function is poorly understood.
Methods: In this retrospective single center trial we assessed the association of systemic inflammation
(surrogated by CRP) and FGF23 regulation in 221 stable non-ischemic heart failure patients (age ≥ 18) with
reduced ejection fraction and an estimated glomerular filtration rate of more than 60 ml/min/1.73m².
Furthermore, we analyzed the prognostic ability of FGF23 and CRP in this population. Fasting ct-FGF23,
highly sensitive CRP and a comprehensive panel of further biomarkers, as well as invasive hemodynamic
measures from right heart catheterization, were used for univariate and multivariate regression analysis.
Results: In bivariate correlation analysis ct-FGF23 was correlated with Cardiac output (r= -0.42);
NTproBNP (r=0.34) and CRP (r=0.31); for all of those p < 0.001. Multivariate linear regression analysis
revealed CRP and CO as independently associated with ct-FGF23 (total model fit; r²=0.32; p <0.001). In
time to event analysis ct-FGF23 was the only independent parameter predicting transplant-free survival.
Conclusion: Our data indicate an association of systemic inflammation and FGF23 in heart failure
independent from renal function and supports the hypothesis that FGF23 may be directly involved in heart
failure.
Assessment of Type 2 Diabetes Patients’ Knowledge of Oral Hypoglycemic Agents
Authors: Kusturica Milica Paut , Maričić Mina , Petrović Ana Tomas , Crnobrnja Veljko , Horvat Olga
Published: December 2019

Objective: Considering that adherence level affects diabetes treatment success and maintenance of glycemic control greatly, the aim of this study was to examine diabetes patients’ adherence to oral hypoglycemic agents (OHAs) and knowledge about their mechanism of action, dosing regimen, and side effects. Material and Methods: This cross-sectional study was conducted on a sample of 100 patients with type 2 diabetes in order to assess their knowledge of OHAs using anonymous questionnaires. Results: Most patients had used OHAs between 2 and 5 years (61.0%), where 78.0% were treated with metformin, and the remaining 22.0% were prescribed sulfonylurea derivatives. Besides drugs used for the treatment of type 2 diabetes, 58.0% of patients took another 1-3 drugs daily for the treatment of other conditions. Although 75.0% achieved a score of 5-6 out of the maximum score of 8, only 2.0% of respondents listed at least 2 side effects of the OHA they used, and none of them could explain its mechanism of action. Most of the information about OHAs was given to patients by endocrinologists (53.0%). Conclusion: More than half of participants considered their knowledge of OHAs insufficient. Results clearly indicate that the respondents were not sufficiently familiar with the mechanism of action and possible side effects of such medications. Information about OHAs given in written form as well as via community pharmacists would contribute to educating type 2 diabetes patients significantly.
STATE INSTITUTION OF SCIENCE SCIENTIFIC AND RESEACH CENTER OF PREVENTIVE AND CLINICAL MEDICINE" STATE ADMINISTRARIVE DEPARTMENT: FROM OUT-PATIENT DEPARTMENT TO THE UNIVERSITY CLINIC
Authors: Dyachuk D. D.
Published: December 2019

STATE INSTITUTION OF SCIENCE SCIENTIFIC AND RESEACH CENTER OF PREVENTIVE AND CLINICAL MEDICINE" STATE ADMINISTRARIVE DEPARTMENT: FROM OUT-PATIENT DEPARTMENT TO THE UNIVERSITY CLINIC
ASSESSMENT OF ASSOCIATIONS BETWEEN CHRONIC KIDNEY DISEASE: GLOMERULONEPHRITIS WITH NEPHROTIC SYNDROME AND BLOOD GROUPS OF AB0 AND RHESUS SYSTEMS
Authors: Kaminskyi V. Ya. , Kovalchuk L. Ye. , Yatsyshyn R. I.
Published: December 2019

The objective of the research was to evaluate the risk of the development of chronic kidney disease: glomerulonephritis with nephrotic syndrome by antigens of blood groups of AB0 and Rhesus (Rh) systems.

Material and methods. We examined 119 patients (76 men and 43 women) with chronic kidney disease: primary glomerulonephritis with nephrotic syndrome. The mean age of the patients was 39.65±14.16 years. The patients underwent a puncture biopsy of the kidney to verify the morphological form of the disease. A survey of 1428 healthy individuals was conducted to determine the populational distribution of blood groups phenotypes of AB0 and Rh systems.

Results. Greater probability of the development of chronic kidney disease: glomerulonephritis with nephrotic syndrome was observed in carriers of 0 Rh+ and AB Rh+ antigens. The fact was interesting that carriers of phenotype 0 Rh– were registered much less of ten in patients than in healthy individuals. This may indicate some resistance to the disease in such individuals. Greater predisposition to the development of chronic kidney disease: glomerulonephritis with nephrotic syndrome was observed in Rh-positive women with blood groups0 (χ2=6.98; р=0.008) and АВ (φ=2.32; р=0.010). The chance of the studied pathology development in Rh-positive women versus Rh-negative was in 2.19 times higher than the same ratio in men. The highest chance to contract the pathology was in Rh-positive women with groups AB and 0 versus B, in 4.49 and 4.34 times more than men, respectively.

Conclusions. Men with phenotypes A Rh– and B Rh– versus 0 Rh–, women with phenotypes AB Rh+ and 0 Rh+ versus A Rh+ and B Rh+ have the highest risk to contract the disease. Individuals of both genders with groups 0 Rh–and B Rh+ may be resistant to the development of the disease.
DIFFERENTIATED APPROACH TO RISK ASSESSMENT OF DEVELOPING PLACENTA-ASSOCIATED COMPLICATIONS IN PREGNANT WOMAN WITH PREECLAMPSIA
Authors: Loskutova T. A.
Published: December 2019

Preeclampsia remains the main cause of maternal and perinatal morbidity and mortality. It was shown that the developments of complications from the mother and fetus side or their absence in women with preeclampsia have different pathophysiological mechanisms. It is necessary to distinguish two types of hypertensive disorders during pregnancy: the first one is severe preeclampsia, which has an early onset and is accompanied by complications that threaten the life of the mother and child. Second – it is a mild pre-eclampsia, that specificfor the late stages of pregnancy and occurs without significant associated complications. It has been shown that the markers of the propensity to develop obstetric and perinatal complications in pregnant women with preeclampsia are the following gene polymorphisms: 1691 GA in gene factor V Leiden – increases the risk in 2.9 times (95 % CI 1.94–4.33), 20210 GA in prothrombin gene – 2.36 times (95 % CI 1.54–3.6), 20210 AA in prothrombin gene – 3.12 times (95 % CI 2.4–4.0). Pregnancy on the background of these gene polymorphisms is associated with severe pre-eclampsia, early onset and development of life-threatening maternal and fetal complications.
HIDDEN COMPLICATIONS OF THE POSTOPERATIVE PERIOD: DIAGNOSIS AND TREATMENT
Authors: Halushko O. A.
Published: December 2019

One of the hidden complications of the postoperative period is hypophosphatemia (HPE), which often develops imperceptibly, but can worsen the overall results of treatment. The objective of the work: to investigate the frequency of development of disorders of phosphate exchange in the postoperative period and to establish the possibility and effectiveness of correction of such violations. Materials and methods. The determination of phosphate levels was carried out in 328 patients undergoing surgical treatment in surgical operations of various surgical status. Results. The highest rate of HPE was observed in patients with burns (23.08 %), after neurosurgical (17.94 %) and abdominal (17.64 %) surgical interventions. It is established that the correction of severe HPE is advisable by intravenous administration of sodium D-fructose-1,6-diphosphate. Conclusion. In the postoperative period, HPE is common, but is successfully corrected to abstract values, which coincides with the clinical improvement of patients.
Farklı Branşlardaki Sporcuların Statik Denge, Alt-Üst Ekstremite Dinamik Denge ve Reaksiyon Zamanlarının İncelenmesi
Authors: TÜRKERİ Cenab , ÖZTÜRK Barışcan , BÜYÜKTAŞ Bilgihan , ÖZTÜRK Demet
Published: December 2019

Bu çalışmada farklı branşlardaki sporcuların statik denge,
alt-üst ekstremite dinamik denge ve reaksiyon zamanları arasında fark olup
olmadığının belirlenmesi ve bu özelliklerin birbirleriyle ilişkilerini
araştırmak amaçlanmıştır. Araştırma Adana ilinde spor yapan, branşlarında
(judo, karate, basketbol, hentbol) en az 1 yıllık geçmişe sahip yaşları
13,11±1,32 yıl, boyları 161,97±10,01 cm, ağırlıkları 51,79±12,21kg, 46 kadın ve
25 erkek toplam 71 sporcu üzerinde yürütülmüştür. Çalışmadan elde edilen
bulgular doğrultusunda; branşlara göre statik denge ve reaksiyon zamanı
arasında anlamlı bir farklılık bulunmamıştır. Branşlara göre judocular lehine
alt ekstremite dinamik denge skorlarında p=0,003 ve basketbolcular lehine üst
ekstremite dinamik denge skorlarında p=0,006 anlamlı farklılık olduğu
bulunmuştur. Reaksiyon zamanı değerleri ile statik denge değerleri arasında ve
reaksiyon zamanı değerleri ile alt ekstremite dinamik denge skorları arasında
anlamlı ilişki çıkmamıştır. üst ekstremite dinamik denge skorları ile reaksiyon
zamanı değerleri arasında düşük (r=─0,232) 
bir ilişki (p=0,05) bulunmuştur. Sonuç olarak, çıplak ayakla farklı
zeminlerde yapılan bireysel mücadele sporlarıyla, ayakkabıyla ve topla yapılan
takım sporları sporcuları arasında üst ekstremite dinamik denge ve reaksiyon
sürati açısından farklılaşma olduğu, basketbol ve hentbol
sporcularının normal çalışmalarına ek olarak minder, tatami gibi yumuşak
zeminlerde denge çalışmaları yapmalarının dinamik dengelerini geliştirebileceği söylenebilir.
Karakterisasi Tes Keterampilan Proses Sains Materi Fluida Statis Berdasarkan Teori Respon Butir
Authors: Fitriani Lani , Ramalis Tauﬁk Ramlan , Efendi Ridwan
Published: December 2019

Keterampilan proses sains (KPS) merupakan salah satu keterampilan yang banyak ditekankan pada kurikulum pendidikan dalam beberapa tahun terakhir ini. Untuk mengetahui capaian keterampilan tersebut, maka dibutuhkan alat ukur yang valid dan reliabel. Oleh karena itu, penelitian dilakukan dengan tujuan untuk mengkarakterisasi tes keterampilan proses sains berdasarkan teori respon butir. Penelitian ini menggunakan desain konstruksi dan validasi tes. Proses konstruksi menghasilkan tes KPS berbentuk pilihan ganda pada materi ﬂuida statis yang mengukur lima aspek KPS. Sedangkan proses validasi didasarkan pada penilaian tes oleh lima orang ahli dan uji coba tes oleh siswa-siswa kelas sebelas dari tiga sekolah di Jawa Barat. Hasil penelitian menunjukkan bahwa tes KPS dapat dikatakan valid baik berdasarkan analisis menggunakan validitas isi V Aiken maupun analisis dengan teori respon butir. Hasil analisis kurva karakteristik tes menunjukkan bahwa tes KPS memiliki daya pembeda dalam kategori baik, tingkat kesukaran dalam kategori sedang dan faktor tebakan semu dalam kategori kurang baik. Hasil analisis fungsi informasi, tes KPS yang telah dikonstruksi reliabel dan dapat digunakan untuk partisipan dengan kategori kemampuan rendah hingga kemampuan tinggi. Dapat disimpulkan bahwa tes KPS pada materi ﬂuida statis valid dan reliabel.
Penerapan Pembelajaran Fisika Menggunakan Multi Representasi untuk Meningkatkan Kemampuan Kognitif dan Pemecahan Masalah Siswa SMA pada Pokok Bahasan Gerak Parabola
Authors: Mardatila Agnesita , Novia Hera , Sinaga Parlindungan
Published: December 2019

Fisika dalam menguasainya dibutuhkan pemahaman dan kemampuan cara representasi yang berbeda-beda. Penggunaan multirepresentasi memfasilitasi peserta didik dengan latarbelakang kecerdasan yang berbeda untuk dapat memahami suatu konsep tertentu. Tujuan penelitian ini adalah untuk mengetahui peningkatan kemampuan kognitif dan pemecahan masalah siswa, level pemecahan masalah siswa, hubungan antara kemampuan kognitif dengan pemecahan masalah, serta tanggapan siswa terhadap pembelajaran menggunakan multirepresentasi. Metode penelitian yang digunakan adalah kuasi eksperimen dengan desain penelitian nonequivalent control group design. Instrumen penelitian berupa tes pilihan ganda untuk mengukur kemampuan kognitif, tes uraian untuk mengukur kemampuan pemecahan masalah, lembar observasi untuk mengetahui keterlaksanaan pembelajaran, dan angket tanggapan siswa untuk mengetahui respon siswa terhadap pembelajaran multirepresentasi. Hasil penelitian menunjukkan terjadi peningkatan kemampuan kognitif berdasarkan nilai N-gain. Pada kelas eksperimen peningkatan kemampuan kognitif berada pada kategori ”sedang” sedangkan kelas kontrol berada pada kategori ”rendah”. Kemampuan pemecahan masalah siswa dievaluasi menggunakan rubrik multiple ways Rosengrant, dengan rata-rata level pemecahan masalah kelas eksperimen berada pada level needs some improvement, sedangkan kelas kontrol berada pada level inadequate. Adapun hubungan kemampuan kognitif dengan pemecahan masalah adalah linier dengan kriteria ”cukup”. Tanggapan siswa ”positif” terhadap pembelajaran menggunakan multirepresentasi pada pokok bahasan gerak parabola.
Komunikasi Interpersonal Mediator Dalam Proses Mediasi Perkara Perceraian di Pengadilan Agama Tulungagung
Authors: Syafaah Darisy , Lismawati Lismawati
Published: December 2019

Abstrak:Penelitian ini membahahas dua persoalan pokok yaitu: 1) Bagaimana komunikasi interpersonal mediator dengan pihak yang berperkara dalam proses perceraian di Pengadilan Agama Tulungagung?, 2) Faktor apa sajakah yang  mendukung dan menghambat komunikasi interpersonal mediator Pengadilan Agama Tulungagung dalam proses mediasi perkara perceraian?. Metode yang digunakan peneliti untuk menjawab permasalahan tersebut adalah metode  kualitatif deskriptif  melalui studi kasus perceraian yang terjadi di Pengadilan Agama Negeri Tulungagung. Adapun untuk memperoleh hasil data secara rinci, penelitian ini menggunakan metode  wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa  1) Mediator mengaplikasikan 5 prinsip hukum komunikasiefektif dalam  melaksanakan mediasi dengan pihak yang berperkara pada kasus perceraian di pengadilan Agama Tulungagung yaitu: empati, menghormati, dapat didengarkan atau dimengerti, kejelasan pesan, dan sikap rendah hati yang ditunjukkan melalui sikap dan tutur mediator, 2) Keberhasilan mediator dalam komunikasi interpersonal  untuk menekan angka perceraian di Pengadilan Agama Tulungagung disebabkan oleh sikap tegas  dan netral mediator dalam mengarahkan pihak yang berperkara  serta sikap pihak berperkara yang terbuka. Namun di sisi lain, komunikasi interpersonal terkadang menunjukkan keberhasilan yang rendah karena permasalahan tawar menawar yang rumit terkait harta gono gini, sikap kukuh para pihak yang berperkara untuk bercerai, serta keengganan mengikuti proses mediasi sebagai jalan untuk mempercepat proses perceraian Abstract:This study addresses two main issues, namely: 1) How is mediator interpersonal communication with litigants in the divorce process in the Tulungagung Religious Court?. To answer this problem, researchers used descriptive qualitative methods oriented to divorce case studies that took place in the Tulungagung District Religious Court. In order to obtain detailed data results, researchers used three methods of data collection, namely interviews, observation and documentation as non-human data sources. The results showed that 1) Mediators applied 5 principles of interpersonal communication in conducting mediation with litigants in divorce cases at the Tulungagung Religion court, namely: empathy, respect, can be heard or understood, clarity of messages, and a humble attitude that was shown through attitude and speech mediator, 2) The success of the mediator in interpersonal communication to reduce divorce rates in the Tulungagung Religious Court is caused by the firm and neutral attitude of the mediator in directing the litigant party and the open attitude of the litigant party.However, on the other hand, interpersonal communication sometimes shows low success because of the problem of complicated bargaining related to property, the firm attitude of the parties to divorce, and reluctance to follow the mediation process as a way to speed up the divorce process.
Efektifitas Digititalisasi Marketing Para Pelaku Usaha Mikro Kecil dan Menengah (UMKM) di Lombok (Analisis Media Equation Theory)
Authors: Rohmah Nurliya Nimatul
Published: December 2019

Abstrak:Ada dua permasalahan dalam penelitian ini yaitu seberapa besar interaksi para pelaku usaha kecil dan menengah (UMKM) di Lombok terhadap media pada kegiatan digitalisasi marketing menurut analisis Media Equation Theory dan seberapa efektifkah digitalisasi marketing para pelaku usaha kecil dan menengah (UMKM) di Lombok dalam pendekatan analisis Media Equation Theory. Untuk menjawab pertanyaan tersebut, peneliti menggunakan metode kualitatif dengan pendekatan analisis media equation theory untuk dapat menelaah interaksi para pelaku usaha kecil dan menengah (UMKM) di Lombok terhadap media pada kegiatan digitalisasi marketing menurut analisis Media Equation Theory dan mengetahui prosentase keefektifan digitalisasi marketing para pelaku usaha kecil dan menengah (UMKM) di Lombok dalam pendekatan analisis Media Equation Theory, peneliti menggunakan subjek penelitian para UMKM Lombok yang mengikuti kelas Gapura Digital dan Womenwill di Lombok pada tanggal 24 Agustus 2019 untuk didapatkan hasil prosentase pada indikator yang telah ditentukan dengan memberikan link questioner yang dijawab secara online, sehingga hasil penelitian dapat langsung diketahui secara akurat.                                    Abstract:There are two problems in this research, Which are how big is the interaction of small and medium enterprises (UMKM) in Lombok using the media in marketing digitalization activities according to the Media Equation Theory analysis and how effective is the marketing digitalization of small and medium entrepreneurs (UMKM) in Lombok in the approach Media Equation Theory analysis. To answer this question, researcher used a qualitative method with a media equation theory analysis approach to be able to examine the interaction of small and medium-sized businesses (UMKM) in Lombok to the media on marketing digitalization activities according to the Media Equation Theory analysis and find out the percentage of the effectiveness of marketing digitalization of small business and medium enterprises (UMKM) in Lombok in the Media approach Equation Theory analysis, researcher used research subjects of the UMKM of Lombok whose took the Gapura Digital and Womenwill classes in Lombok on August 24, 2019 to obtain the percentage results on the indicators that have been determined by providing a questioner link answered online, so that research results can be immediately known accurately
Monitoring Perparkiran Mobil Berbasis Sensor Ultrasonik dan Mikrokontroller ESP8266
Authors: Nur Dahlia , Pradana Yori Putra , Kadir Sahbuddin Abdul
Published: December 2019

â€” The number of motorized vehicles in Indonesia is increasing rapidly every year. Based on data from the Central Statistics Agency (BPS) in 2017, the number of motorized vehicles with Passenger Car vehicles reached 15,493,068 units. The number has increased compared to 2016 amounted to 14,580,666 units. The increase as the number of motorized vehicles has an impact of the availability of parking lots in a number of locations. Every driver who will park the vehicle wants to get the location / lot of the parking lot as soon as possible. However, the unavailability of parking capacity information in a parking area causes the user to go around first to get an unload parking space, if the parking lot is full, the user even has to go back out because he did not get a parking space. This study designed and built an ESP8266 microcontroller and PING ultrasonic sensor provided information about the availability of parking lots were still unoccupied in this monitoring system. It is hoped can improve the efficiency of parking users who are looking for vacant parking lots and make it easier for parking admins in parking monitoring management. The results showed that the monitoring system that was built could provide information about the availability of empty parking lots and integrated databases to store vehicle owner information based on parking cards. Parking lot information is included on the parking card given to users entering the parking area.
A randomized double blind study of a green and black tea agent, AssuriTEA®, in healthy male subjects
Authors: Capodice Jillian , Herrlinger Kelli , Ceddia Michael , Chirouzes Diana , Katz Aaron
Published: December 2019

Background: Green and black teas have known anti-oxidant and anti-inflammatory properties. The current study was a prospective randomized, double-blind, placebo controlled study of 3 doses of a water-extracted green and black tea agent (AssuriTEA® [AT]).  Methods: Subjects who met inclusion criteria were randomized to one of four groups: 1000, 500, or 250 mg AT or placebo for 28 days. At baseline (BL) and day 28, serum antioxidant capacity, quality of life and safety were assessed.   Results: Of the 55 subjects screened, 43 were considered evaluable. Age was 56.77 ± 2.83 years (mean ± SEM).  Evaluable subjects demonstrated improved antioxidant status, as measured by ferric iron reducing antioxidant power at all doses over the placebo (p < 0.05). There was significant improvement in cellular antioxidant protection in the 1000 mg AT group versus the placebo (p=0.032).  Glucose levels were higher in the placebo group versus the 250 mg AT group (p=0.023) and there was a significant improvement in systolic blood pressure in the 250 mg AT group at day 28 versus BL (p=0.048).  In the 1000 mg AT group, there was a significant decrease in systolic blood pressure at day 28 versus BL (p=0.017).  There was a significant improvement in the vitality category in the 1000 mg AT group (p=0.029). Overall, AT was safe and well tolerated with no differences in adverse events or serum chemistries between groups.   Conclusions: Results demonstrate that the administration of AT resulted in improvement of serum antioxidant status, vitality level, blood glucose, and systolic blood pressure in test subjects. Key Words: Green tea, black tea, Camellia sinensis, antioxidant status, blood glucose, systolic blood pressure, and quality of life
Chemopreventive Effects of Magnesium Chloride Supplementation on Hormone Independent Prostate Cancer Cells
Authors: Quiroz Elsa , Oseni Saheed Oluwasina , Kumi-Diaka James
Published: December 2019

Background: Lifestyle significantly impacts the risk factors associated with prostate cancer, out of which diet appears to be the most influential. An emerging chemopreventive approach, which involves the adequate intake of dietary constituents, has shown great potential in preventing the occurrence or progression of cancer. Magnesium is known to be an essential cofactor for more than 300 enzymatic processes, and is responsible for the regulation of various cellular reactions in the body. A plethora of studies have shown evidence that changes in the intracellular levels of magnesium could contribute to cell proliferation and apoptosis in some normal and malignant cells. The aim of the study was to investigate the effects of magnesium chloride (MgCl2) in DU-145 prostate cancer cells. Methodology: Cultured DU-145 cells were subjected to graded concentrations or doses (50-500 µM) of MgCl2 for 48 hours. The cell viability was assessed using MTT and Resazurin reduction assays. NBT assay was also used to assess the treatment-induced intracellular ROS levels. Acridine Orange/Ethidium Bromide (AcrO/EtBr) and Rh123/EtBr fluorescent stains were used to assess the cell death type and mitochondrial membrane potential (Δψm) respectively. Results: The results revealed a dose-dependent decrease (P < 0.05) in cell viability in treated DU-145 cells after 48 hours. The NBT assay also revealed a dose dependent biphasic response (P < 0.05) in intracellular levels of ROS. There was a drop (P < 0.05) in ROS levels in all groups except at 100 µM, where ROS level was higher than the control. Apoptosis was the primary mode of cell death as observed in the fluorescence analysis. Conclusion: Our finding suggests that MgCl2 may be potentially chemopreventive for prostate cancer. This justifies further studies into its mechanism of action in DU-145 and other prostate cancer cell types. Keywords: Prostate cancer, Magnesium chloride, Chemoprevention, Apoptosis, Reactive Oxygen Species.
A drink containing amino acids and chromium picolinate improves postprandial glycemia at breakfast in healthy, overweight subjects
Authors: Ostman Elin , Forslund Anna , Oste Rickard , Bjorck Inger
Published: December 2019

Background: Chromium (Cr) and certain amino acids (AA) have individually shown to improve postprandial glycemia.Method: The present randomized, controlled, cross-over trial in 19 healthy, overweight subjects (age 51±1y and BMI 27.3±0.3 kg/m2; mean±SEM) evaluated a combination of leucine, isoleucine, valine, lysine and threonine (5AA) with Cr. Postprandial glycemia and insulinemia were measured following a bread meal, served with carbonated water (Ref) or carbonated water containing 5AA, Cr-picolinate (CrPic) or a combination (5AA+CrPic).Results: The 5AA+CrPic and 5AA, respectively, lowered the incremental glucose peak (P< 0.001) by almost 30% compared to Ref. No significant differences in incremental insulin peaks were found but, during the first 15 min, 5AA induced a higher insulin response (+112%; p<0.01) compared to Ref. Interestingly, 5AA+CrPic reduced the initial AA-induced insulin increase by more than 50%, indicating improved insulin economy. Conclusions: These observations suggest that a drink containing both 5AA and CrPic attenuate postprandial glycemia in healthy “at risk” subjects.Keywords: Amino acids, chromium picolinate, postprandial glycemia, insulin economy, drink
Survival rate of Saccharomyces boulardii adapted to a functional freeze-dried yoghurt, related to processing, storage and digestion by experimental Wistar rats
Authors: Martinez-Flores Hector Eduardo , Tranquilino-Rodriguez Eunice , Rodiles-Lopez Jose O. , Zamora-Vega Rafael , Salgado-Garciglia Rafael , Perez-Sanchez Rosa E.
Published: December 2019

Background: Saccharomyces boulardii is a probiotic clinically effective in the prevention and treatment of antibiotic induced diarrhea in both children and adults, Clostridium difficile infections, inflammatory bowel disease, and other gastrointestinal disorders. However, the microorganisms need to survive the gastrointestinal transit and arrive to their action site alive in order to exert their beneficial effects. Microencapsulation is an alternative to improve the viability of probiotic in foods which can also survive in the gastrointestinal conditions. Freeze--drying is a method of dehydration that does not affect nutrients and bioactive compounds, such as probiotics contained in foods. All of them will increase the survival rate of S. boulardii.Purpose of this study: This study focused on formulae freeze-dried yogurt containing inulin, vegetable palm oil, and S. boulardii, both as free cells and in microencapsulated form. Also, theeffect of ampicillin associated S. boulardii.Methods: Yogurts were given to an “in vivo” digestion process, using male Wistar rats. The survival of S. boulardii was subsequently evaluated in colon and feces. For this study, six treatments of four of rats were used: i) control rats ii) rats fed with yogurt containing S. boulardii as free cells, iii) rats fed with yogurt containing S. boulardii in micro-encapsulated form, iv) control rats fed with penicillin, v) rats fed with ampicillin plus yogurt containing S. boulardii as free cells, and vi) rats fed with penicillin plus yogurt containing S. boulardii in micro-encapsulated form.Results: The study demonstrated it was feasible to freeze-dry the S. boulardii and incorporate it into a yogurt made with skim milk, inulin, and unsaturated vegetable oil. The freeze-drying process not affected the survival of the S. boulardii (p<0.05). Microencapsulation increased the survival of S. boulardii on 1.77-Log CFU/g, and the presence of S. boulardii was only detected in colon and feces of those rats which ingested ampicillin, regardless to the formula contained the probiotic.Conclusion: This study demonstrated that freeze-drying maintains the survival of S. boulardii in the evaluated foods and that micro-encapsulation increases the survival of this probiotic. Furthermore, S. boulardii was installed in the gastrointestinal tract when the microbial flora was  damaged by ampicillin.Keywords: Yogurt, probiotic, Saccharomyces boulardii, micro-encapsulation, freeze-drying.
Influence of selenium bio-fortification on nutritional compositions, bioactive compounds content and anti-oxidative properties of young ricegrass (Oryza sativa L.)
Authors: Chomchan Rattanamanee , Siripongvutikorn Sunisa , Puttarak Panupong , Rattanapon Rungtip
Published: December 2019

Background: Young ricegrass (Oryza sativa L.) can be introduced as one of functional food product since sprouts have been much interested in this era due to their high nutritive values. Bio-fortification of selenium is one strategy to enhance plant bioactivity. However, the level of selenium used is varied among species of plants, hence, the proper level needs to be explored.Objective: To investigate the influence of selenium bio-fortification on nutritional compositions, bioactive compounds content and anti-oxidative properties of young ricegrass.Methods: Sodium selenite ranging 0, 10, 20, 30 and 40 mg Se/L has been hydroponically bio-fortified into ricegrass then grown for 8 d and investigated the changes of growth characteristics, selenium content, accumulation of bioactive compounds and anti-oxidative properties.Results:  Results revealed that selenium bio-fortified exogenously increased the accumulation of selenium in ricegrass by 529% at 40 mg Se/L treatment without negatively changes in leaves biomass at the day of harvesting. However, root part weight slightly decreased when increased selenium level. Selenium at concentration of 10 and 20 mg Se/L can stimulate the production of phenolic compounds and antioxidant activities in young ricegrass as measured by DPPH, ABTS, FRAP and chelating assay. Conversely, higher level of selenium fortification reduced the accumulation of phenolics in ricegrass may due to pro-oxidant expression.Conclusion: Selenium bio-fortification can be used as a useful technique to improve quality of ricegrass plantation. 10 mg Se/L treatment was an ideal to trigger the synthesis of phenolics which exhibited high antioxidant activities. While, 40 mg Se/L treatment was ultimate for the production of Se plant foods.Keywords: Antioxidant activities; Bio-fortification; Ricegrass; Selenium
Efficacy of a novel herbal composition licorice flavonoid oil in subject with metabolic syndrome: a randomized double-blind placebo-controlled clinical study
Authors: Hosoe Kazunori , Nakagawa Kaku , Ueda Takahiro , Hosoda Masato , Panda Sanjib Kumar , Morikawa Hideyuki , Jha Sandeep
Published: December 2019

Background: In order to evaluate the effects of licorice flavonoid oil (LFO) on waist circumference, blood pressure, lipid profile, body fat composition, body weight, body mass index (BMI), and fasting blood glucose in patients with metabolic syndrome, a 12 week randomized double-blind placebo-controlled study was conducted. Methods: Fifty patients with metabolic syndrome aged between 18-75 years were assigned to either the LFO or placebo group. Abdominal waist circumference, blood pressure, body weight, and BMI were assessed at baseline, week 4, week 8, and week 12. Clinical laboratory examinations, fat composition, and fasting blood glucose level were assessed at baseline (week 0) and final visit (week 12).Results: A total of 50 subjects (25 subjects in each group) completed the 12 week study. Significant changes from baseline were observed in body weight, waist circumference, and BMI in the LFO group compared to the placebo group from week 4 or week 8 onwards. No adverse events were noted throughout the study. Conclusion: The present study suggests that LFO is a promising dietary nutrient for improving metabolic syndrome, particularly through its beneficial effect of reducing body weight, BMI, and possibly the amount of visceral fat. Keywords: licorice flavonoid oil; Glycyrrhiza glabra L.; metabolic syndrome; body mass index
Improving Animal Diets to Increase Relevance to Human Populations
Authors: Hintze Korry J. , Benninghoff Abby D. , Ward Robert E.
Published: December 2019

Background: Rodent models have been an invaluable resource for biomedical research and have been instrumental for countless advances in our understanding of biology and human disease.  However, inherent to using these models is the issue of translatability of research findings to human populations. Some differences between humans and rodents can never be reconciled because of key differences in physiology.  However, rodent models have evolved over time through innovations in genetics and standardized animal diets, resulting in reduced variability across experiments. Developing animal diets that more closely emulate what humans eat will help increase the translational fidelity of animal models to human populations. This review will focus on the role of basal laboratory diets for improving animal models. Keywords: laboratory rodent diets, total Western Diet, allometric scaling, nutrient density scaling