bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathological and oncological outcomes for pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: a systematic review and meta-analysis
Authors: Hou Sen , Liu Fan , Gao Zhidong , Ye Yingjiang
Published: July 2022

Background: Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC) in the middle third. According to literature reports, PPG decreased the incidence of dumping syndrome, bile reflux, gallstone formation, and nutritional deficit in comparison with conventional distal gastrectomy (CDG). However, the debates about PPG has been dominated by the incomplete lymphadenectomy and oncological safety. We carried out a systematic review and meta-analysis to evaluate the pathological and oncological outcomes of PPG.Methods: The protocol was registered in PROSPERO under number CRD42022304677. Databases including PubMed, Embase, Web of science and the Cochrane Register of Controlled Trials were searched before February 21,2022. The outcomes included the pooled odds ratio (OR) for dichotomous variables and weighted mean differences (WMDs) for continuous variables. All outcomes were calculated with 95% confidence intervals (CI). Meta-analysis was performed using STATA software (Stata 14, Stata Corporation, Texas) and Review Manager 5.4. Results: A total of 4500 patients from 16 studies were included. Compared with CDG, PPG group has less lymph nodes harvested (WMD=-3.09; 95% CI -4.75 to -1.43; P<0.001). Differences of resected lymph nodes were observed in No.5, No.6, No.9 and No.11p stations. There were no differences in lymph nodes metastasis of each station. Shorter proximal resection margins (WMD= -0.554; 95%CI, -0.999 to -0.108; P=0.015) and distal resection margins (WMD= -1.569; 95% CI -3.132 to -0.007; P=0.049) were observed in PPG group. There were no significant differences in pathological T1a stage (OR=0.99; 95% CI 0.80 to 1.23; P=0.88), T1b stage (OR=1.01; 95% CI 0.81 to 1.26; P=0.88), N0 stage (OR=0.97; 95% CI 0.63 to 1.48; P=0.88), tumor size (WMD = -0.10; 95% CI, -0.25 to 0.05; P = 0.187), differentiated carcinoma (OR=1.04; 95% CI 0.74 to 1.47; P=0.812) or signet ring cell carcinoma (OR=1.22; 95% CI 0.90 to 1.64; P=0.198). No significant differences were observed between the groups in terms of overall survival (HR=0.22 95%CI 0.01 to 6.69; P=1.000) and recurrence free survival (HR=0.31; 95%CI 0.00 to 24.35; P=0.687).Conclusions: The meta-analysis of existing evidence demonstrated that PPG had comparable survival outcomes with CDG. However, PPG harvested less lymph nodes in No.5, No.6, No.9 and No.11p stations. We also found that PPG has shorter proximal resection margin and distal resection margin, meaning more remnant stomach would be preserved in PPG.
Sulfamethazine degradation by sulfite through GAC@Ni/Fe three-Dimensional（3D） Particle Electrode activation:contribution of active substance and synergy
Authors: Li Siwen , Lin Yingzi , Zhu Suiyi , Liu Gen , Shi Chunyan
Published: July 2022

In this study, GAC@Ni/Fe particles were employed as particle electrodes and sulfite hetero activators for the synergistic degradation of sulfamethazine (SMR) in a three-dimensional electrode reactor.The effects of operating parameters (cell voltage, particle electrode dosage, pH value, and sulfite dosage) on SMR degradation were investigated experimentally.When the cell voltage is 5V, sulfite is 1mM, particle electrode is 40g and pH is 7, the degradation efficiency can reach 96.91% in 30min.The superiority of the 3D(GAC@Ni/Fe)/Sulfite system in SMR removal was confirmed by comparative experiments and reaction synergy factor analysis.The surface changes of GAC@Ni/Fe particles before and after electrode reaction were characterized by XRD, XPS and FTIR.The electrochemical performance of GAC@Ni/Fe was investigated by LSV, Tafel and EIS, further illustrating its important role in synergistic degradation.Electron paramagnetic resonance (EPR) and quenching experiments demonstrate that the degradation of SMR in the 3D (GAC@Ni/Fe)/Sulfite system is the result of the combined action of free radicals and non-radicals.·OH, SO4−· and 1O2 contributed 51%, 12% and 37% to SMR removal, respectively.The mineralization rate of TOC is 54.57% (30min), which also shows the high-efficiency mineralization ability of the system for SMR.The research provides a strong foundation for the 3D (GAC@Ni/Fe)/Sulfite system as a green process in the removal of emerging organic pollutants.
A phase II study of N-acetylcysteine in cancer patients with severe COVID-19: clinical outcomes and biological correlates
Authors: Johnson William , Kalvin Hannah , Panageas Katherine , Nicodemus Jasmine , Cathcart Elizabeth , Lin Ya-Hui , Hosszu Kinga , Lee Christina , Hamlin Paul , Horwitz Steven , Intlekofer Andrew , Joffe Erel , Kumar Anita , Batlevi Connie , Matasar Matthew , Moskowitz Alison , Noy Ariela , Palomba M , Salles Gilles , Straus David , von Keudell Gottfried , Zelenetz Andrew , Boelens Jaap Jan , Babady N , Maslak Peter , Wolchok Jedd D. , Vardhana Santosha
Published: July 2022

Acute SARS-CoV-2 infection results in high mortality rates in patients with cancer with patients dying from a combination of virus and inflammation-driven respiratory failure. We conducted a two-arm, single-institution phase II study of N-acetylcysteine in patients admitted to Memorial Sloan Kettering Cancer Center with severe COVID-19 from May 2020 to April 2021. A total of 42 patients were treated: 13 patients in arm A (ICU) and 29 patients in arm B (non-ICU). In total, 23% of patients in arm A and 69% of patients in arm B met the predetermined clinical definition of treatment success. Patients meeting a successful primary endpoint were more likely to exhibit decreases in systemic levels of interleukin-6 and C-reactive protein and had both higher proportions of PD-1-expressing effector memory and fewer terminally differentiated CD8+ T-cells. These results suggest that many patients with cancer and severe COVID-19 experience clinical and immunologic improvement with N-acetylcysteine therapy.
Modular structures and the delivery of inpatient care in hospitals: a network science perspective on healthcare function and dysfunction
Authors: Ben-Tovim David I. , Bajger Mariusz , Bui Viet Duong , Qin Shaowen , Thompson Campbell H.
Published: July 2022

BackgroundReinforced by the COVID-19 pandemic, the capacity of health systems to cope with increasing healthcare demands has been an abiding concern of both governments and the public. Health systems are made up from non-identical humans and physical components interacting in diverse ways in varying locations. It is challenging to represent the function and dysfunction of such systems in a scientific manner. We describe a novel approach to that dilemma.General hospitals with large emergency caseloads are the resource intensive components of health systems. We propose that the care-delivery services in such entities are modular, and that their structure and function can be usefully analysed by contemporary network science. We explore that possibility in a study of Australian hospitals during 2019 and 2020.MethodsWe accessed monthly snapshots of whole of hospital administrative patient level data in two general hospitals during 2019 and 2020. We represented the organisation inpatient services as network graphs and explored their graph structural characteristics using the Louvain algorithm and other methods. We related graph topological features to aspects of observable function and dysfunction in the delivery of care.Results We constructed a series of whole of institution bipartite hospital graphs with clinical unit and labelled wards as nodes, and patients treated by units in particular wards as edges. Examples of the graphs are provided. Algorithmic identification of community structures confirmed the modular structure of the graphs. Their functional implications were readily identified by domain experts. Topological graph features could be related to functional and dysfunctional issues such as COVID-19 related service changes and levels of hospital congestion.Discussion and Conclusions Contemporary Network Science is one of the fastest growing areas of current scientific and technical advance. Network Science confirms the modular nature of healthcare service structures. It holds considerable promise for understanding function and dysfunction in healthcare systems, and for reconceptualising issues such as hospital capacity in new and interesting ways.
Prolonged longitudinal transcutaneous auricular vagus nerve stimulation effects on striatal functional connectivity in patients with major depressive disorder
Authors: Zhang Shuai , He Jia-Kai , Wang Yu , Zhong Gang-Liang , Zhao Ya-Nan , Li Shao-Yuan , Xiao Xue , Yang Zheng-Yi , Zhao Bin , Wang Lei , Zhang Jin-Ling , Zhai Wei-Hang , Jiang Tian-Zi , Fang Ji-Liang , Rong Peijing
Published: July 2022

The cortical-striatal abnormalities are commomly found in the mental disorders. Instant transcutaneous auricular vagus nerve stimulation (taVNS) has been found to modulate the ventral striatial functional connectivity (FC) in patients with major depressive disorder (MDD). However, the neural mechanism of prolonged longitudinal taVNS treatment on different striatal subregions has not yet been elucidated. We used resting state functional magnetic resonance to estimate the effect of taVNS on the FC of striatal subregions in patients with MDD. Compared with healthy control subjects, lower prefrontal-striatal rsFC and higher occipital-striatal rsFC were found in patients with MDD. While the prefrontal-striatal rsFC increased and the occipital-striatal rsFC decreased after taVNS treatment. Specifically, the decreased Hamilton Depression Scale (HAMD) scores were positive correlated with the change of rsFCs between left ventral caudate (vCa) and right ventral prefrontal cortex (vPFC), and negatively correlated with the change of rsFCs between left vCa and right superior occipital gyrus. The rsFC between right nucleus accumbens (NAc)and right dorsal medial prefrontal cortex (dmPFC)at baseline predicted the longitudinal taVNS effects on HAMD score at 8 weeks. Therefore, taVNS can relief depressive sympotoms by modulating the aberrant striatal rsFC in patients with MDD. The strength of rsFC between the right NAc and right dmPFC may serve as a potential biomarker for the prolonged longitudinal taVNS and predict treatment responses.
Investigation of changes in water status and distribution of Quercus acutissima seeds during desiccation using LF-NMR and MRI methods
Authors: Chen Haiyan , Shen Yongbao
Published: July 2022

Background
The Quercus acutissima seed is a typical temperate recalcitrant seed; storing the seeds for longer than a year after maturation and shedding is challenging because they are sensitive to water loss. Therefore, research on the Q.acutissima seed water loss site and the dynamic changes in seed water status during desiccation can offer a theoretical foundation for the storage of these seeds safely as well as a reference for the mechanism study of recalcitrant seeds.
Results
The site of water loss in Q.acutissima seeds was explored using nuclear magnetic resonance imaging combined with the results of scanning electron microscopy of the seed coat. The results showed that the micropyle and the scar were identified as the main water loss sites of Q.acutissima seeds. The LF-NMR tests indicated that water in the Q. acutissima seeds exists in three states: free water, immobile water, and bound water. The effects of each water status on seed vigor were also analyzed with the changes in seed germination rate during desiccation. During desiccation, both the bound and free water of Q.acutissima seeds were lost significantly, resulting in the death of the seeds. Finally, the relationship between the transverse relaxation signal and the water content of Q.acutissima seeds during drying is established, providing a foundation for quick and nondestructive assessment of Q.acutissima seed water content.
Conclusion
Rapid and non-destructive monitoring of the drying process of Q. acutissima seeds is made possible by MRI and NMR technology. By conducting them, we can determine the sites of water loss, the migration rules of different water statuses during seed drying, and the relationship between the causes of seed desiccation sensitivity and changes in water status.
Comparison of the effectiveness of anchoring needles and coils in localizing multiple nodules in the lung
Authors: Huang Ya-Yong , Wang Tao , Fu Yu-Fei , Shi Yi-Bing , Cao Wei , Hou Ju-Pan
Published: July 2022

Background: Recently, a new type of pulmonary nodule positioning needle has been clinically adopted. We aimed to evaluate the efficacy and safety of a new type of localization needles compared with coils for the simultaneous localization of multiple pulmonary nodules guided by computed tomography (CT) prior to video-assisted thoracoscopic surgery (VATS).Materials and Methods: From January 2021 to March 2022, 87 pulmonary nodules from 40 patients were localized using the new localization needle. From January 2020 to December 2020, 68 pulmonary nodules in 31 patients were localized using coils. The relative outcomes were compared. Results: The success rate of pulmonary nodule localization in the needle group was 97.7% while that in the coil group was 98.5%. In the needle group, the time needed for locating the first nodule was significantly shorter compared with the coil group (10.9 min vs. 17.2 min, P<0.05). Moreover, the time needed per patient was also significantly shorter for the needle group compared with the coil group (23.7 min vs. 30 min, P<0.05). The incidence of pneumothorax in the needle group was 25.0% vs. 12.9% in the coil group (P>0.05). The rate of pulmonary hemorrhage in needle group was 40.0 % vs 32.3% in coil group (P>0.05). The success rate of VATS wedge resection was 100% in both groups. Conclusions: Both disposable pulmonary nodule localization needles and coils are safe and effective for CT-guided localization of multiple pulmonary nodules of the same stage prior to VATS. However, the needles are time-saving to use than the coils.
Prediction of HPV status in oropharyngeal squamous cell carcinoma based on radiomics and machine learning algorithms: a multi-cohort study
Authors: Zhinan Liang , Wei Zhang , Yudi You , Yabing Dong , Yuanzhe Xiao , Xiulan Liu
Published: July 2022

Background: Human papillomavirus status has significant implications for prognostic evaluation and clinical decision-making for oropharyngeal squamous cell carcinoma patients. As a novel method, radiomics provides a possibility for non-invasive diagnosis. The aim of this study was to examine whether computed tomography radiomics and machine learning classifiers can effectively predict human papillomavirus types and be validated in external data in patients with oropharyngeal squamous cell carcinoma based on imaging data from multi-institutional and multi-national cohorts.Materials and methods: 651 patients from three multi-institutional and multi-national cohorts are collected in this retrospective study: OPC-Radiomics cohort (n=497), MAASTRO cohort (n=74), and SNPH cohort (n=80). OPC-Radiomics cohort was randomized into training cohort and validation cohort with a ratio of 2:1. MAASTRO cohort and SNPH cohort were used as independent external testing cohorts.1316 quantitative features were extracted from the computed tomography images of primary tumors. After feature selection by using logistic regression and recursive feature elimination algorithms, 10 different machine‑learning classifiers were trained and compared in different cohorts. Results: By comparing 10 kinds of machine‑learning classifiers, we found that the best performance was achieved when using a random forest-based model, with the area under the receiver operating characteristic curves(AUCs) of 0.97, 0.72, 0.63, and 0.78 in the training cohort, validation cohort, testing cohort 1 (MAASTRO cohort), and testing cohort 2 (SNPH cohort), respectively. Conclusions: The random forest-based radiomics model was effective in differentiating human papillomavirus status of oropharyngeal squamous cell carcinoma in multi-national population, which provides the possibility for this non-invasive method to be widely applied in clinical practice.
Functional characterisation of SiFPGS2 gene of foxtail millet in folates accumulation and root development
Authors: Zhang Yijuan , Zhang Chongmei , Man Xiaxia , Men Yihan , Ren Xuemei , Li Xueyin , Han Lida , Sun Zhaoxia , Yang Yang , Hou Siyu , Han Yuanhuai
Published: July 2022

Folates content in foxtail millet (Setaria italica) are higher than that in major crops. Polyglutamylation of folates could enhance their compartmentalization, reducing their transport, increase their affinities with enzymes and increase the stability of the folates pool in Arabidopsis. The polyglutamylation reaction are catalyzed by folylpolyglutamate synthetase (FPGS). But FPGS function in foxtail millet is still elusive. In this study we identified Setaria italica FPGS2 (SiFPGS2) genes in foxtail millet by blast analysis with AtFPGS1/2/3 protein sequences. The phylogenetic tree analysis, protein function domain analysis and docking analysis results showed that SiFPGS2 belong to FPGS subfamily, possessed the tetrahydrofolypolyglutamate synthase domain, could bind tetrahydrofolate (THF) as substrate. Subcellular localization predicted that SiFPGS2 localized in the chloroplast. Cis-acting elements prediction analysis indicated that there were meristem expression motif and root specific motif in SiFPGS2 promoter. Over-expressed SiFPGS2 in Arabidopsis not only increased the folates content, but also increased the root length, and further propidium iodide staining result suggested that the increased root length was owning to the promotion of cell division in root apical meristem zone. SiFPGS2 catalyzed the polyglutamylation of THF and lead to the increase of folates content and root length by promotion of root apical meristem zone cell division. SiFPGS2 can be used as a candidate gene for biofortification of folates in Gramineae crops via genetic engineering.
Mandibular 3D position changes in miniscrew-assisted rapid palatal expansion(MARPE): a retrospective clinical trial using CBCT
Authors: Lei Qiaoling , He Wendan , Lei Qiyin , Xiong Peiying , Wang Zhongdong
Published: July 2022

Background: The aim of this study was to evaluate the immediate and short-term effects of miniscrew-assisted rapid palatal expansion (MARPE) on mandibular 3D position in treatment of skeletal Class I malocclusion with maxillary transverse deficiency in adults.Methods: A retrospective study was conducted using cone-beam computed tomography (CBCT) scans of 20 adults with skeletal Class I malocclusion and maxillary transverse deficiency who underwent MARPE. Three CBCT scans were obtained before treatment (T0), immediately after expansion (T1) and after a six-month consolidation period (T2). Mandibular landmarks were measured with respect to axial, sagittal, and coronal reference planes respectively. Repeated measures ANOVA and LSD multiple comparison were used for statistical analysis.Results: The mandibular rotated clockwise at T1 and relapsed to its initial position at T2. The lateral displacement was unremarkable.Conclusions: When MARPE was used to treat skeletal Class I malocclusion with maxillary transverse deficiency, it caused a transient clockwise rotation of the mandible. However, the mandible did not show sagittal, vertical and horizontal position changes in short-term evaluation.
Monoclonal Antibodies Against CGRP (R): Non-responders and Switchers: Real World Data from a Large Case Series
Authors: Kaltseis Katharina , Filippi Vera , Frank Florian , Eckhardt Christine , Schiefecker Alois , Broessner Gregor
Published: July 2022

ObjectiveAssessement of the responder and non-responder rate to consecutive monoclonal CGRP-antibody (CGRP-mAb) treatment, the presence of side effects, analysis of predictors of response and loss of efficacy evaluation over time. Methods We conducted a retrospective analysis including 171 patients with episodic (EM) or chronic migraine (CM), who received one, two or three different CGRP-(R)-mAbs. Non-response was defined as ≤50% reduction of monthly migraine days (MMDs) in EM and ≤ 30% reduction of MMDs in CM after 3 months of treatment. Results71.9% responded to the first mAb. Side effects led to treatment discontinuation in 5.3%. Of the 26 patients who did not respond to the first mAb or experienced a loss of efficacy over time, 11 (42.3%) responded to the second and two of 7 to the third monoclonal antibody. Poor response to therapy was associated with a higher monthly headache frequency (p = 0.042), pre-existing psychiatric disorder (p = 0.032), and a higher number of prior preventive migraine therapies (p = 0.022).ConclusionOur findings support mAb-class switch in non-responders or in patients experiencing a loss of efficacy. The use of a third CGRP-mAb could be beneficial for some patients. Early use of CGRP-mAbs in the prevention of migraine might help to avert chronification of migraine and treatment-refractory patients.
Home ranges and activity patterns of Sunda pangolins (Manis javanica) in Vietnam
Authors: Gray Russell J. , Le Dung , Nguyen Huyen Thi Thanh , Cao Long Nhat , Nguyen Tan , Pham Thong , Willcox Daniel , Chen Tiffany , Nguyen Thai
Published: July 2022

Current knowledge of Sunda pangolin (Manis javanica) movement ecology has only been recorded from a small island in Singapore, which may not be representative of their range throughout Southeast Asia. Here we provide an update on Sunda pangolin movement ecology from radio telemetry projects in three distinct ecoregions of Vietnam, including a montane region, lowlands, and wetlands. In this study, we radio-tracked 12 pangolins rescued from the illegal wildlife trade and translocated to protected areas where existing conspecific populations had been previously detected. We used an autocorrelated Kernel Density Estimation (aKDE) method to identify the home ranges of each pangolin. Finally, we supplemented our movement ecology analyses with 177 camera trap images to identify activity patterns of Sunda pangolin populations in each location. Activity periods of Sunda pangolins occurred most frequently from 03:00–04:00 (range: 24:00–04:00). The average home range of translocated Sunda pangolins examined throughout our projects in various ecoregions of Vietnam is estimated to be 1.58 km2 and did not vary significantly between sexes, mass, or habitat. However, there was a marked decrease in range size with decreasing size of suitable forest space.
Is educational quality, not just educational attainment, associated with cardiometabolic health: A test in two samples
Authors: Cundiff Jenny M. , Lin Shayne , Faulk Robert , McDonough Ian
Published: July 2022

Educational quality may be a closer correlate of physical health than more commonly used measures of educational attainment (e.g., years in school). We examined whether a widely-used performance-based measure of educational quality is more closely associated with cardiometabolic health than educational attainment (highest level of education completed), and whether perceived control, executive functioning, and health literacy link educational quality to cardiometabolic health. In two samples, educational quality was associated with cardiometabolic health above and beyond educational attainment, other demographic factors (age, ethnoracial category, sex), and fluid intelligence. Counter to expectations, neither perceived control, executive function, nor health literacy significantly mediated the association between educational quality and cardiometabolic health. Findings add to the growing literature suggesting that current operationalizations of the construct of education likely underestimate the association between education and multiple forms of health. To the extent that educational programs may have been overlooked based on the apparent size of associations with outcomes, such actions may have been premature.
Why curling stones curl?- modelling and numerical experiment -
Authors: Ohashi Tetsuya
Published: July 2022

In curling, a sport played on ice, players release stones on the ice sheet at initial speeds of translation and rotation aiming to a target location with curled trajectory. To elucidate why the stones curl, we focus on the fact that asperities on the leading and trailing parts of the bottom of stone pass through the same spot on the ice surface twice within a short period of time. We also consider the fact that the ice is at a very high temperature close to its melting point and the recovery from the damaged state after the microscopic fracture and plastic deformation by the friction takes place quickly. Theoretical models for the magnitude and direction of the friction force between the stone and ice are developed and the motion of the stone were numerically analysed. Contribution of several factors that may be involved in friction on ice surfaces was investigated in detail. Analysis results were compared with experimental ones in literature and some were found to be in good agreement.
Deep and Contextually Engineered Features for Metaphor Detection
Authors: Razali Md Saifullah , Halin Alfian Abdul , Chow Yang-Wai , Norowi Noris Mohd , Doraisamy Shyamala
Published: July 2022

The focal point of this work is to automatically detect metaphor instances in short texts. It is the study of extricating the most optimal features for the task by using a deep learning architecture combined with carefully handcrafted contextual features. All of these will be discussed in detail in this paper. It is also found that a few sets performed well when they are used independently, but the others not so much. However, even the latter sets become very useful after the combination process with the former sets. Finally, the combined feature sets undergo the classification using well-known machine learning classification algorithms. It is decided that all the five algorithms are used for the purpose of comparison. The best algorithm for this task is found to be Support Vector Machine (SVM). The outcome of all the experiments are good in all the metrics used. Furthermore, result comparison in terms of F1-measure to existing works in the same domain is compiled and stated in this paper. The comparison on each feature set is also stated as additional information.
Assessment of the Consistency of Categorical Features within the DZHK Biobanking Basic Set
Authors: Yusuf Khalid , Tahar Kais , Sax Ulrich , HOFFMANN Wolfgang , KREFTING Dagmar
Published: July 2022

Data quality in health research encompasses a broad range of aspects and indicators. While some indicators are generic and can be calculated without domain knowledge, others require information about a specific data element. Even more complex are indicators addressing contradictions, that stem from implausible combinations of multiple data elements. In this paper, we investigate how contradictions within interdependent categorical data can be identified and if they give additional information about possible quality issues, their cause, and mitigation options. The 19 data elements that represent four biosample types including their pre-analytic states within the DZHK Biobanking basic set are exported to the CDISC Operational Data Model (ODM), transformed and loaded into a tranSMART instance. Through the implementation of a data quality assessment workflow as a SmartR plug-in, statistical information about the domain-specific consistency of interdependent values are retrieved, assessed, and visualized. Data quality indicators have been selected for the assessment according to common recommendations found in the literature. Different contradictions could be discovered in the dataset including mismatch of interdependent values in the pre-analytic states of blood and urine samples, as well as primary and aliquoted samples. The overall assessment rating shows that 99.61% of the interdependent values are free of contradictions. However, measures within the EDC design to avoid contradictions may result in overestimated missing rates in automatic, item-based quality assessment checks. Through consistency checks on interdependent categorical features, we demonstrated that consistency flaws can be found in the categorical data of biobanking metadata and that they can help to detect issues in the data entry process. Our approach underscores the importance of domain knowledge in the definition of the consistency rules but also knowledge about the EDC implementation of such consistency rules to consider the impact on item-based quality indicators.
Chinese National Consensus Committee of Experts on Kawasaki Disease and Chinese Journal of Contemporary Pediatrics: The expert consensuses on Intravenous Immunoglobulin, aspirin, and Glucocorticoid
Authors: Shuying Ren , Fangming Deng , Zhongdong Du , Xiaodong Yang , Lijian Xie , Hong Wang , Fuyong Jiao
Published: July 2022

Kawasaki disease (KD) is an acute vasculitis with unknown etiology usually occurring in children under 5 years old. It is one of the common acquired heart diseases in children and can cause serious complications such as coronary injury. Although Intravenous immunoglobulin (IVIG) combined with oral aspirin (Asp) is currently recognized as the most effective treatment in KD acute stage and also the first-line treatment to prevent the cardiovascular complications of KD, Glucocorticoid (GC) is mainly used for KD patients with the high risk of Coronary artery aneurysm, no immunoglobulin response and confirmed Coronary artery aneurysm (CAA). There are already consensus guidelines on the diagnosis and treatment of KD at home and abroad, but there are inconsistent opinions in the literature on the mechanism, optimal timing, and dosage of drug treatment for KD. This article will summarize the three consensuses. This review will summarize three consensus items.
Prognostic value of the preoperative fibrinogen-to-prealbumin ratio in patients with resectable pancreatic cancer
Authors: li zhiwei
Published: July 2022

Background and purpose
Systemic inflammation, malnutrition, abnormal blood coagulation, and immunosuppression play important roles in the occurrence and development of tumors. This study aims to compare the fibrinogen-to-prealbumin ratio (FPR), fibrinogen-to-albumin ratio (FAR), and fibrinogen-to-mean platelet volume ratio (FMR) as predictors of the prognosis of patients with resectable PC.
Methods
Using retrospective research methods, 318 patients were enrolled, whom were divided into two groups, namely, the training set and the validation set. The binary logistic test was used to analyse the joint predictive value. The Cox proportional hazards regression model was used to analyse the influence of multiple factors on prognosis, and the Kaplan–Meier method was used to draw survival curves.
Results
The survival curve showed that patients with resectable PC with low preoperative FPR (P = 0.043) and low FAR (P = 0.019) had significantly longer overall survival (OS); Correlation analysis showed that FPR is related to tumour location (P < 0.001), FAR (P < 0.001), and FMR (P < 0.001). The t-ROC analysis showed that the combination of FPR and CA19-9 has a greater predictive value for the prognosis of patients with resectable PC. In subgroup analysis according to stage, FPR was more predictive of the prognosis of patients with stage II PC.
Conclusion
FPR and FAR have a consistent predictive effect on the prognosis of patients with resectable PC, but FPR has a stronger predictive effect on prognosis. At the same time, FPR combined with CA19-9 has better predictive value for patients with resectable PC.
An improved wavelet threshold method and its application in seismic data denoising
Authors: Qin Feilong , Liu Jian , Cheng Yali , Lu LiulI
Published: July 2022

The collected field seismic data is disturbed by random noise, which is not conducive to seismic data interpretation, the noise must be removed from seismic data. Soft and hard threshold methods of wavelet transform can eliminate this noise of seismic data, but they have some shortcomings in signal denoising. So this paper proposes an improved threshold method to seismic data denoising. The improved threshold method can eliminate random noise effectively, which is evaluated by means of root mean square error (RMSE) and signal-to-noise ratio (SNR). Furthermore, according to the decomposition layers of wavelet transform, the selection of reasonable threshold value is obtained, and the simulation results proved that the improved method can well remove noise and the wavelet basis function of wavelet transform is sym3 and the best decomposition level of the new method is 3 layers. Using the improved threshold method to remove noise in actual seismic data, the results show that lots of noise is removed, and the resolution of seismic data profile after noise reduction is high and the texture of it is clear, especially, the effect of the improved threshold method in seismic data denoising is better than that of soft and hard threshold methods.
On Non-Penalization SEMDOT Using Discrete Variable Sensitivities
Authors: Fu Yun-Fei , Long Kai , Rolfe Bernard
Published: July 2022

Density-based topology optimization algorithms, such as solid isotropic material with penalization (SIMP), pursue solid/void solutions to yield distinct topologies, however blurry or zigzag boundaries are unavoidable. By contrast, newly developed elemental volume fraction based algorithms pursue solid/void grid points, and the intermediate elements, consisting of both solid and void grid points, are artificially defined as boundary elements through which smooth boundaries can be formed. Smooth-Edged Material Distribution for Optimizing Topology (SEMDOT) algorithm is a typical elemental volume fraction based method developed based on the SIMP framework. However, the current version of SEMDOT needs to use the material penalization scheme in SIMP to facilitate the distinction of solid, void, and boundary elements. This framework restriction has motivated the development of the non-penalized SEMDOT algorithm to establish the physically meaningful relation between the elemental volume fraction and its material property. This study adopts discrete variable sensitivities for solid, void and assumed boundary elements instead of continuous variable sensitivities to eliminate the material penalization scheme and obtain efficient smooth topological layouts. The efficiency, effectiveness, and general applicability of the proposed non-penalized SEMDOT algorithm are demonstrated in three case studies containing compliance minimization, compliant mechanism design, and heat conduction problems, as well as thorough comparisons with penalized SEMDOT. The numerical results show that the convergency of non-penalized SEMDOT is stronger than penalized SEMDOT, and improved results can be obtained by non-penalized SEMDOT.
Global Weak Solutions for 1D Compressible Navier-Stokes/Allen-Chan System with Vacuum
Authors: Li Yinghua , Yan Yuanxiang , Ding Shijin , Chen Gaoyang
Published: July 2022

In this paper, we consider a diffffuse interface model coupled by Navier-Stokes equaitons and Allen-Cahn equations. We study 1D compressible system with free boundary when the initial density is assumed to be compactly supported and connects to vacuum continuously. The global existence of weak solutions is established by using line method.
Perspectives through a Two-Slit Camera
Authors: Crannell Annalisa , Abraham Ojima , Dai Jihang , Gong Yike , McClain Rebecca , Ramaswamy Nithya , Reisner: Charles , Shinn Evan , Wang Shen
Published: July 2022

We give geometric constructions for drawing the images of cubes as seen in a two-slit camera: an apparatus for which, instead of having a single barrier with a pinhole, there are a pair of barriers each with a slit allowing light to pass through. Although a two-slit camera is an example of a “generalized linear camera”, the images of lines are often hyperbolas. Nonetheless, we can use ruler-and-compass constructions to draw the images of cubes in one-, two-, and three-point perspective.
ANALYSIS OF THE MARKET OF LARB AND MATERIALS AT THE INTERNATIONAL AND NATIONAL LEVEL IN THE FIELD OF THE INDUSTRIAL ECONOMY
Authors: Kirilieva A.
Published: July 2022

The article identifies the relevance of the study of the industrial sector of Ukraine's economy. The industry is a crucial determinant of Ukraine's sustainable development and a definition of the country's image in the international arena of world relations. A robust industrial sector allows you to conduct domestic and international economic policy effectively and position yourself as a competitive business entity. It was found that the current stage of development of world economic relations in Ukraine is characterized by the expansion of all forms of international economic relations based on the rapid growth of productive forces due to rapid progress. As a result, the concentration of production and increase in its size is constantly increasing, increasing the tendency to internationalize economic life, contributing to international development. The Ukrainian market of paints and varnishes is considered a promising industry. Paint and varnish industry – a branch of the chemical industry, as a result of which the company produces a variety of decorative and protective products, hardeners, accelerators, resins for synthetic varnishes and more. The range of production and production of paints as of 2021 is quite extensive, but there are many options for improving and developing new receptors. It is determined that the LFM market is developed and competitive compared to other branches of the chemical industry. The level of imported paints and varnishes is much lower than the share of domestic goods in the Ukrainian market. This trend allows us to state the competitiveness of LFM at the national level. Ukrainian manufacturers will be able to maintain and improve their positions under the conditions of modernization of the production process, equipping the shop with the latest equipment and training of employees. The analysis will be helpful to potential investors in the Ukrainian coatings industry since the latter is quite attractive for development and has prospects for future branching of economic activity. The main competitive advantages for the development of enterprises of the LFM industry are the resource base, the possibility of training, and the development of human capital for these enterprises.
PECULIARITIES OF CONSUMER BEHAVIOR IN COVID-19 CONDITIONS: BIBLIOMETRIC ANALYSIS
Authors: Kolesnyk D.
Published: July 2022

The events caused by COVID-19 are among the most significant and unpredictable events of recent years. Every country, economy, and human sphere could not ignore the Pandemic that unfolded in early 2020. And, of course, it has strongly influenced consumer behavior. Under these conditions, the main psychological factors influencing consumer behavior were anxiety and fear and the panic they caused. External and internal restrictions on business and consumer activity associated with the coronavirus pandemic have led to a temporary decline in production and consumption in the economy. Measures for social distancing, self-isolation, quarantine, adopted in many countries, and other factors have created new consumer trends that need to be detailed.
Accordingly, the article aimed to determine the essence of research in the pandemic impact on consumer behavior, published in publications indexed by the leading database Scopus.
As a result of bibliometric analysis of 1007 publications indexed by the Scopus database for 2020-2021 on the impact of the Pandemic on consumer behavior, four most potent clusters were identified: the impact of the Pandemic on changing consumer habits in all spheres of life; characteristics of consumer attitudes; health of different categories of the population; study of the effects on the body caused by coronavirus infection. Determining the impact of changes in consumer demand in terms of achieving economic and social goals by enterprises and states remains little studied.
A study of the geographical affiliation of authors of scientific papers in this area showed the most significant number of publications published by scientists from the United States, China, Britain, India, Italy, Spain, South Korea, and Australia. At the same time, the number of publications in the Scopus database published by domestic authors is relatively insignificant, which once again confirmed the lack of research and timeliness of the study in Ukraine.
Interest in the topic is constantly growing. Because the problem remains open – Covid-19 continues to change the lives of people around the world, changing not only consumer, food, etc. behavior of the population and the principles of doing business, but forms new and new goals of sustainable development of society.
MANAGEMENT OF HIGH BLOOD PRESSURE IN MOROCCO:WHAT PLACE FOR RGMPS ?
Authors:   Faculty of Medicine of Rabat, Mohammed V University., Fatima-Zahrae Chrifi , Bouchra Assarag ,   National School of Public Health, MSPS.,   National School of Public Health, Directorate of Epidemiology and Disease Control, MSPS., Nassira Idsalem ,   National School of Public Health, Directorate of Epidemiology and Disease Control, MSPS.
Published: July 2022

Background:High blood pressure (HBP) is the main cardiovascular risk factor and a public health problem that is easy to recognize and treat. Therefore, good practice recommendations for treating hypertension in adults were developed in Morocco in 2012 as part of the ten recommendations of good medical practice (RGMPs). The objective of our study was to explore the degree of use of RGPMs for HBP among physicians in primary health care facilities (PHCFs). Methods:This mixed-methods exploratory study was based on the NHS* sustainability model. Physicians from 21 PHCFs in the Skhirat-Temara prefecture were interviewed using pretested questionnaires over a period of 6 weeks. We observed their practice in the management of HBP to assess the degree of application of RGMPs. The research strategy was based on a methodological triangulation validation technique. Quantitative data were analysed using Epi Info software version 7.2.2.6, and the significance of associations was determined using Students t test (significant if the P valueË‚0.05). The qualitative analysis consisted of a thematic content analysis of specific grids. Results:Fifty-eight questionnaires were completed, with a predominance of female participation. The average age was 48.60 years (Â±5.57 years) [3961] 83% worked in urban areas. The average age of seniority of function was 10 years (Â±5.61 years) [121]. Most participants (78%) had received continuing education on hypertension. Sixty-six percent were aware of RGMPs for HBP, but only 58% followed them. The total average degree of compliance with all recommendations was 73.27%. The statistical analysis revealed a significant difference in the degree of compliance between rural (79.72%) and urban (71.92%) areas (p=0.01) and among trained (75.44%) and untrained (65.73%) physicians (P=0.001). The main determinants related to their application were the adaptability and credibility of the RGMPs, information on and sharing of the recommendations, and staff training. Conclusions: Our study indicated that the degree of application of RGMPs in the management of hypertension by physicians in the PHCFs of the Skhirat-TÃ©mara prefecture is satisfactory and allowed us to make recommendations for action on the determinants of their proper application.
ACUTE EFFECT OF CYPERMETHRIN ON NUTRIENT UTILIZATION AND HISTOPATHOLOGY OF CLARIAS GARIEPINUS (BURCHELL, 1822)
Authors:   Department of Fisheries, Lagos State University, Ojo, Lagos State, Nigeria., Olusegun Olufemi Whenu , Gabriel Olarinde Mekuleyi ,   Department of Fisheries, Lagos State University, Ojo, Lagos State, Nigeria.
Published: July 2022

The toxicity of cypermethrin (a pesticide) on fingerlings of African catfish, Clarias gariepinus was investigate with emphasis on histopathological effects. The juvenile were exposed to 0, 1.0, 2.0, 3.0, 4.0 and 5.0ppb of cypermethrin under experimental condition. The growth, nutrient utilization and feed utilization parameters (Weight gain, Average Daily Weight Gain, Percentage Weight Gain , Specific Growth Rate , Feed Intake ,Feed Conversion Ratio and Protein Intake were not significantly different(P>0.05) at the different concentration. However, histopathological changes were observed on the gills and liver of the experimental fish. In the gills, filament cell proliferation, cellular infiltration, haemorrhage and gill damage were observed. In the liver, there was vacuolation of hepatocytes and necrosis. However, there was no observable histological change in the intestine at the various concentrations of exposure. Respiratory stress, erratic swimming and instant death of fish were observed in exposed fish, which varies with the concentration of the toxicant and it showed that mortality increased with increase in concentration. This study concluded that Cypermethrin is highly toxic to fish and therefore should be avoided in aquatic ecosystem.
IMPLEMENTATION STRATEGY OF SHEEP FARMING IN BEKASI REGENCY WITH INTEREST-FREE PARTNERSHIPMODEL USING SWOT ANALYSIS
Authors:   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia., a Sodikun , b Sukardi ,   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia., Ismayana Andes ,   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia., Anggraeni Elisa ,   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia.
Published: July 2022

Thisresearchwas a qualitativedescriptive study thataimedtodeterminethestrategyfordeveloping a multipliedsheep farming model in Setu District, Bekasi Regency. The locationoftheresearchwasdeterminedtherebecausetheimplementationofthisresearchalsocarriedoutcomparisons in severalplaces in West Java, Central Java andEast Java. The data obtained were analyzedusing SWOT analysis. Basedonthe SWOT analysis, the main strategyrecommendedforthedevelopmentofthesheep farming modelisthe SO (Strengths-Opportunities) strategywiththeformulationofstrategiesincludingdeveloping a profit-sharingpartnershipsystemwithoutusuryanddevelopingthe internal capabilitiesoffarmersandutilizinglivestockintereststoincreasethescaleofsheep farming businesstobecomemoreadvancedandefficient. Establish a sheepbreederassociation in order tostreamlinethemarketingnetwork in order totakeadvantageofmarketdemandopportunitiesthathave not beenmetandoptimallyutilizeabundantagriculturalwaste.
O Meio Ambiente como Matriz do Pensamento: A Geografia em Face da Educação Ambiental
Authors: Santos Luiz Henrique de Oliveira , Pinto Vicente Paulo dos Santos
Published: July 2022

O artigo apresenta uma análise de estudos teóricos apontando para a importância de uma educação voltada à percepção do ser humano na natureza e na produção do seu meio, podendo utilizar recursos da Geografia e da Educação Ambiental (EA). Para alcançar o proposto, foi realizada uma revisão bibliográfica sobre: o conceito de meio ambiente, os movimentos ambientalistas e a Educação Ambiental, o pensamento dos geógrafos anarquistas do século 19 e a complexidade na educação. O resultado foi a proposta de uma abordagem que englobe práticas para uma educação que não esteja separada ou fragmentada do meio, mas busque a sua compreensão de forma complexa, por meio da reflexão sobre: o eu e o lugar, o eu e a sociedade e o lugar e a sociedade no contexto global.