bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial and temporal characteristics of NDVI on based hydrogeological division in Golmud River watershed of Qinghai-Tibet Plateau，China
Authors: Ye Shuigen , Zhang Chenglong , Chu Hongzhen
Published: May 2023

The hydrogeological conditions of the piedmont diluvium are one of the key controlling factors for the growth of local vegetation. This paper analyzes the spatial-temporal variation of vegetation in the Golmud River watershed by the linear slope method, Sen’s slope method and Hurst index method based on the hydrogeological division using the MODIS data of NDVI from 2000 to 2018 in the Qaidam Basin on the Qinghai-Tibet Plateau. The results show that the vegetation coverage in the study area is closely related to the hydrogeological conditions, and the hydrogeological unit of the watershed determines the zonal distribution of surface vegetation. Fraction Vegetation Coverage (FVC) is larger in the mountains and fine soil overflow division, but less than 0.1 in the piedmont Gobi, the wetland salt lake and the northern diluvium division. From 2000 to 2018, FVC has improved greatly in the mountains and fine soil overflow division. In the past 20 years, the area of high coverage vegetation in the watershed has nearly doubled, while desert area has been continuously reduced by 20%, these changes mainly occurred in the mountains and fine soil overflow division. The vegetation coverage of degradation is scattered along the southern coast of Dabson Lake, around the Huolanguole River, and around Yuzhu peak. The vegetation of consistent improvement in the future is mainly distributed in the mountains and fine soil overflow division. The vegetation of consistent degradation is mainly distributed around the upper reaches of Holangole River, the upper reaches of Jiaga Riqu, around Yuzhu Peak, and the south bank of Dabson Lake. Meteorological factors are the driving force of continuous improvement of vegetation coverage. This study has scientific significance for local ecological environment protection.
Psychometric testing of the 10-item Perceived Stress Scale for Chinese nurses
Authors: Du Xiaoyu , Liu Xiqin , Zhao Yajun , Wang Song
Published: May 2023

BackgroundNurses bear a lot of stressors at work. The 10-item Perceived Stress Scale (PSS-10) is a widely used self-reported scale for measuring the global perception of stress. However, there is a lack of the use of PSS-10 in Chinese nurses. This study aimed to test the psychometric properties of the PSS-10 among Chinese nurses.MethodsA total of 708 Chinese nurses completed the PSS-10, the Big Five Inventory, and the Depression Anxiety and Stress Scale. Confirmatory factor analysis (CFA) tested the factor structure of PSS-10. Cronbach's alpha coefficient and test-retest correlation examined the scale reliability. Pearson correlation and hierarchical regression analyses tested the convergent and concurrent validity of PSS-10.ResultsCFA revealed that a two-factor model fits the structure of PSS-10 in Chinese nurses. The scale demonstrated adequate internal consistency and test-retest reliability, and satisfied convergent validity with relations to Big Five personality traits. Evidence for concurrent validity was found via the observation that the PSS-10 score explained incremental variance in predicting anxiety, depression and stress.ConclusionsOur findings suggest that PSS-10 is a sound measure of perceived stress in Chinese nurses and can be used in future research and practice on stress management and coping among Chinese nurses.
Exploring the association between EEG microstates during resting-state and error-related activity in young children
Authors: Bagdasarov Armen , Roberts Kenneth , Brunet Denis , Michel Christoph M. , Gaffrey Michael S.
Published: May 2023

The error-related negativity (ERN) is a negative deflection in the electroencephalography (EEG) waveform at frontal-central scalp sites that occurs after error commission. The relationship between the ERN and broader patterns of brain activity measured across the entire scalp that support error processing during early childhood is unclear. We examined the relationship between the ERN and EEG microstates – whole-brain patterns of dynamically evolving scalp potential topographies that reflect periods of synchronized neural activity – during both a go/no-go task and resting-state in 90, 4-8-year-old children. The mean amplitude of the ERN was quantified during the − 64 to 108 millisecond (ms) period of time relative to error commission, which was determined by data-driven microstate segmentation of error-related activity. We found that greater magnitude of the ERN associated with greater global explained variance (GEV; i.e., the percentage of total variance in the data explained by a given microstate) of an error-related microstate observed during the same − 64 to 108 ms period (i.e., error-related microstate 3), and to greater parent-report-measured anxiety risk. During resting-state, six data-driven microstates were identified. Both greater magnitude of the ERN and greater GEV values of error-related microstate 3 associated with greater GEV values of resting-state microstate 4, which showed a frontal-central scalp topography. Source localization results revealed overlap between the underlying neural generators of error-related microstate 3 and resting-state microstate 4 and canonical brain networks (e.g., ventral attention) known to support the higher-order cognitive processes involved in error processing. Taken together, our results clarify how individual differences in error-related and intrinsic brain activity are related and enhance our understanding of developing brain network function and organization supporting error processing during early childhood.
Elastic Deep Sparse Self-representation Subspace Clustering Network
Authors: Wang Qiaoping , Chen Xiaoyun , Li Yan , Lin Yanming
Published: May 2023

Subspace clustering model based on self-representation learning often use $\ell_1$ , $\ell_2$ or kernel norm to constrain self-representation matrix of the dataset. In theory, $\ell_1$ norm can constrain the independence of subspaces, but which may lead to under-connection because the sparsity of the self-representation matrix. $\ell_2$ and nuclear norm regularization can improve the connectivity between clusters, but which may lead to over-connection of the self-representation matrix. Because a single regularization term may cause subspaces to be over or insufficiently divided, this paper proposes an Elastic Deep Sparse Self-representation Subspace Clustering Network (EDS-SC), which imposes sparse constraints on deep features, and introduces the elastic network regularization mixed $\ell_1$ and $\ell_2$ norm to constraint self-representation matrix. The network can extract deep sparse features and provide a balance between subspace independence and connectivity. Experiments on human faces, objects, and medical imaging datasets prove the effectiveness of EDS-SC network.
The Effectiveness of Herbal Remedies on the Hot Flashes in Postmenopausal Women: A Systematic Review and Network Meta- analysis Study
Authors: Keshavarzi Fatemeh , Salari Nader , Jambarsang Sara , Tabatabaei Seyyed Mohammad , Zhaleh Mohsen , Shahsavari Soodeh
Published: May 2023

Purpose:This study was done to conduct a network meta-analysis (NMA) which offers a comprehensive evaluation of the treatment effects of herbal medicine for flashes of post-menopausal women and identifies the most commonly used herbs.
Methods: According to PRISMA-NMA, a systematic search of Persian and English databases, including SID, Magiran, the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, CINAHL, and AMED, was carried out without a time limit until March 10, 2022. The careful examination of this study's questions was selected according to PICO criteria to find the appropriate keywords. A meta-analysis of the Bayesian network was carried out using “BUGSnet” (Bayesian inference Using Gibbs Sampling to conduct a Network meta-analysis) package in R software.
Result and conclusion: Our review includes 45 RCTs (n = 3615 patients). The effect estimates and credible intervals produced by the preceding model for severity outcome showed that the difference between placebo and Silybum marianum, Soy, and Valerian treatments are statistically significant at the 95% level. The Silybum marianum and soy medicine were high ranks than the other treatments suggesting that it is the most beneficial treatment for the outcome among the treatments included in the severity hot-flash evidence network. Ranking the value of all these herbal medicines makes opportunities that might help design treatment algorithms to be validated in prospective clinical trials.
Assessing the knowledge and practices of smallholder pig farmers and associated risk factors for swine gastrointestinal disorders in Masindi district, Uganda
Authors: Majalija Samuel , Tumwine Gabriel , Kiguli Juliet , Owori Benard , Isabirye Robert Alex , Waiswa Peter
Published: May 2023

Background:Piggery production is a main income source for the rural poor in Uganda, where 1.3 million households own about 4.47 million pigs. Nonetheless, health challenges and lack of knowledge by the farmers affect the productivity and profits of the pig enterprises. Thus, this study determined the knowledge and practices among smallholder pig farmers and the associated risk factors for pig gastrointestinal disorders in Masindi district, Uganda.Methods:A cross-sectional survey was conducted using a closed-end questionnaire interview of 170 smallholder pig farmers in the rural district of Masindi, from April to July 2020. The qualitative data was analyzed and presented as frequencies, percentages, and their 95% confidence intervals. Bivariate and multi-variate analysis were used to determine factors associated with GIT disorders.Results:Of the 170 farmers, males and females were equal (50%), mostly as pig owners (91.2%), rural folks (88.8%), who raised other animal species (72.9%) and with 5-10 years (72.4%) of experience. Of these, 67.6% were married, mainly in age ranges of groups 19-50 (90.6%) and 47.6% had attained primary school level. Pig rearing was for income generation (95.5%) and 79.4% reported GIT on their farms, affecting local breeds (57.0%) of all age groups and throughout the year. Similarly, a majority of the farmers identified common clinical signs associated with GIT, transmission routes and adherence to biosecurity practices. However, 62.9% treated the sick pigs, 40.6% sold the sick pigs and only 25.9% consulted a veterinarian.At multivariable logistic regression analysis, being a female farmer (p = 0.018, OR = 3.163, CI: 1.213, 8.244); mixing of different herds of pigs (p=0.003, aOR =4.141, 95%CI (1.317,13.013); feeding pigs on raw tubers (p=0.017, aOR=2.703, 95% CI (1.198,6.099) and scavenging (p <0.001, aOR= 9.605, 95%CI (2.131,43.289) were significantly associated with GIT.Conclusion:Poor husbandry practices especially feeding on raw tubers, scavenging and mixing of different herds of pigs were associated with widespread pig GIT disorders. Involving women in strategies to improve pig GIT health as equal partners is suggested. Farmers are encouraged to adopt confinement and housing of pigs as the minimum good husbandry practices for sustainable pig production.
Imaging of colorectal adenomas with pseudoinvasion and malignant polyps using two-photon excitation microscopy
Authors: Florea Maria-Alexandra , Eftimie Lucian George , Glogojeanu Remus Relu , Hristu Radu , Stanciu George A. , Costache Mariana
Published: May 2023

Purpose
Even though the incidence and mortality rates of colorectal cancer varies widely, it remains one of the most frequently diagnosed cancers in the world. Efforts are made to prevent the development of colorectal cancer by detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps is based on hematoxylin and eosin staining examination. Difficult cases, such as adenomatous polyps with epithelial misplacement could benefit from certain ad-ditional diagnostic methods.
Procedures
The objective of this paper is to highlight stromal changes that appear in malignant polyps and polyps with pseudoinvasion, using two-photon excitation microscopy (TPEM), a technique largely used in the medical field in recent years.
Results
Examination of TPEM images revealed a different distribution and density of collagen fibers at the front of invasion, in malignant polyps, compared to the area of pseudoinvasion.
Conclusions
TPEM could be useful in distinguishing true invasion in malignant polyps from pseudoinvasion, based on a better visualization of the local stromal changes.
A case presenting with thyrotoxicosis, which is thought to be related to radiation-induced thyroiditis
Authors: Boyacı İhsan
Published: May 2023

Background: Thyrotoxicosis is characterized by diverse symptoms, various etiological causes, and a number of different treatment options. Rational and appropriate treatment requires an accurate diagnosis. A well-made differential diagnosis and consideration of concomitant medical conditions are essential for an accurate diagnosis. We present a detailed differential diagnosis of an instructive case with thyrotoxicosis onset which might be associated with more than one etiological factor.Case Report: A 45-year-old woman who received chemoradiotherapy for a known laryngeal tumor was admitted with complaints of palpitation, tremor, sweating, and amenorrhea. She had also been using lithium for nearly two years with a diagnosis of bipolar disorder. On examination, she was pale, with tremors, and sweaty. Her heartbeat was 124 beats/min. The thyroid was nonpalpable. TSH was suppressed, free T3 and free T4 were high. TSHR-Ab and autoantibodies were not detected. Acute phase reactants were found to be normal. Bilateral thyroid lobes and size of isthmus were normal in thyroid ultrasonography. The technetium uptake level was determined as 0%. In the etiology, it was thought that the case of thyrotoxicosis, which developed based on radiotherapy-induced thyroiditis, developed hypothyroidism over time due to permanent damage to the thyroid follicles. L-thyroxine was started in the hypothyroid phase, euthyroid was provided with 75 µg and she was followed up.Conclusion: For a rational treatment and follow-up, the etiology must be determined precisely. For this, a detailed anamnesis, a comprehensive physical examination, and rational, cost-effective, and good laboratory practices are required. It should be kept in mind that thyrotoxicosis may pass into the hypothyroid phase in the follow-up. The fact that each step contains clinical lessons and that it is an educational and instructive case necessitated presenting it.
Barriers and Facilitators to the Implementation of Family Cancer History Collection Tools in Oncology Clinical Practices
Authors: Allen Caitlin
Published: May 2023

Introduction
This study aimed to identify barriers and facilitators to the implementation of family cancer history (FCH) collection tools in clinical practices and community settings by assessing clinicians’ perceptions of implementing a chatbot interface to collect FCH information and provide personalized results to patients and providers. By identifying design and implementation features that facilitate tool adoption and integration into clinical workflows, this study can inform future FCH tool development and adoption in healthcare settings.
Methods
Quantitative data was collected using implementation science measure surveys to evaluate the acceptability, adoption, appropriateness, feasibility, and sustainability of the chatbot tool for collecting FCH, and semi-structured interviews were conducted to gather qualitative data on respondents' experiences using the tool and recommendations for enhancements.
Results
We completed 19 interviews with providers (n = 9, 47%), clinical staff (n = 5, 26%), administrators (n = 4, 21%) and other staff (n = 1, 5%) affiliated with the NCI Community Oncology Research Program. FCH was systematically collected using a wide range of tools at sites, with information being inserted into the patient’s medical record. Participants found the chatbot tool to be highly acceptable, with the tool aligning with existing workflows, and were open to adopting the tool into their practice.
Conclusions
The varying clinical workflows across clinic sites necessitates that future FCH tool development accommodates customizable implementation strategies. A one-size-fits-all approach to implementation of FCH collection tools in clinical workflows is not feasible and options for implementation should be considered during tool development to enhance the uptake of FCH in clinical practices and community settings.
Estudo etnobotânico de espécies alimentícias em quintais agroflorestais na zona de amortecimento do Parque Nacional das Sete Cidades, Estado do Piauí, Brasil
Authors: Santos Emanuela Gonçalves dos , Nunes Ernane Nogueira , Santos Suellen da Silva , Lucena Camilla Marques de , Lucena Reinaldo Farias Paiva de
Published: May 2023

Esse estudo buscou registrar a diversidade de espécies alimentícias existentes em quintais agroflorestais presentes no entorno da zona de amortecimento do Parque Nacional das Sete Cidades. Foram realizadas entrevistas semiestruturadas com os moradores da Comunidade Cachoeira. Foi calculado o Fator de Consenso do Informante (FCI), para verificar o grau de consenso das informações, e o Valor Local para verificar se existiam diferenças no conhecimento entre homens e mulheres. O Teste de Spearman foi usado para verificar correlações entre o tamanho dos quintais e a quantidade de espécies mencionadas. Foram entrevistados nove homens (52,94%) e oito mulheres (47,06%). Foram mencionadas 130 citações de usos alimentícios, distribuídas em 33 espécies, pertencentes a 20 famílias botânicas, sendo 10 espécies nativas (30,30%) e 23 exóticas (69,70%). Destacaram-se, pelo número de espécies, as famílias Anacardiaceae, com 12,12%, seguida de Cucurbitaceae, Rutaceae e Solanaceae, todas com 9,09%. Dentre as formas de vida, destacam-se aquelas com hábito de árvore, arbusto e ervas, com 27,27% cada. Os frutos destacaram-se com 75,39% das citações. O consumo in natura dos frutos se destacou com 60,77% das citações. O FCI foi de 0,75, indicando que existe um considerável grau de consenso entre os moradores da comunidade, e o coeficiente de correlação de Spearman, foi de 0,576, indicando moderada correlação. A partir do teste estatístico, verificou-se que não existem diferenças significativas de conhecimento entre os gêneros.
Atypical Radiological Findings of Capillary Hemangioma in Right Atrium: A
Case Report
Authors: Seo An Na , Park Byunggeon , Lim Jae-Kwang , Byun Jungsup , Park Ji Eun , Cha Jung Guen , Hong Jihoon , Park Seo Young , Park Jongmin
Published: May 2023

Background::

Cardiac hemangiomas account for only 2.8% of primary cardiac tumors and are caused by the abnormal proliferation of endothelial cells and
excess blood vessels. Typical radiological findings of cardiac hemangioma demonstrate intense contrast enhancement.

Case Presentation::

Here we report the case of a 69-year-old man who presented with a right atrial mass found incidentally with multimodal imaging findings,
including echocardiography, computed tomography (CT), and magnetic resonance imaging (MRI). This case presented with poor enhancement
within right atrial mass on dynamic contrast-enhanced CT scan and gadolinium-enhanced first-pass perfusion image of cardiac MRI. After surgical
resection, the pathologic diagnosis of cardiac capillary hemangioma was made.

Conclusion::

Cardiac hemangioma could be included in the differential diagnosis for cardiac neoplasms demonstrating poor enhancements on CT and MRI
scans.
Low-Cost Instrument to Monitor Sulphur Dioxide Emissions Based on The DOAS Method
Authors: Zen Nur , Huboyo Haryono Setiyo , Romadhon Moch. Syarif , Fatkhurrahman Januar Arif , Amrulah Sidna Kosim
Published: May 2023

Various techniques to measure SO2 concentration based on Differential Optical Absorption Spectroscopy (DOAS) have been widely developed and applied for various measurements. However, most of the applications are still relatively expensive. Some efforts have been made to reduce the cost by using Ultraviolet Light Emitting Diodes (LEDs) as light sources, showing promising results. Further reductions can be possibly made by providing an alternative to replace high spectral resolution spectrometers widely used in DOAS applications since those spectrometers are commercially expensive. This paper studies the feasibility of a DOAS instrument using a low-cost spectrometer and UV-LEDs as light sources. The resolution of the spectrometer is 0.7 nm. With this resolution, it is expected that the instrument hardly captures narrow band structures of SO2 optical absorption in the spectral range between 280 nm and 320 nm when measuring SO2 gas concentration lower than the limits of SO2 emissions regulated by the Indonesian government. To compensate for this drawback, narrow and broad bands of optical absorption structures are considered in the data analysis to achieve a detection limit far below the regulated limits. To capture the broadband structures, four UV-LEDs are used to cover spectral absorption from 250 nm to 320 nm. The instrument was calibrated using eight different standard concentrations of SO2. The correlation between the readings and the standard concentrations is high, indicated by the Pearson correlation coefficient of 0.9999. It was also found that the lowest concentration the instrument can distinguish from blank samples or the Limit of Detection is 16 ppm. However, the instrument can precisely measure concentrations higher than or equal to 25 ppm with a standard deviation of less than 10% of the mean concentration measured from five measurements. This is far below the required legal limits, below 229 ppm. After the calibration, the DOAS instrument was used to measure SO2 sampled from the emission of burning coals. To compare, a commercial SO2 sensor was used to measure the same gas. The results indicate that the difference in the readings between the two instruments is around 6% of the concentration.
Results of a Phase II Trial Testing the Resensitization With Trabectedin in Platinum-resistant Ovarian Cancer
Authors: MARQUINA GLORIA , MANZANO ARANZAZU , BENAVENTE CELINA , MACIAS NATALIA PEREZ , RIVAS ANA , DIAZ-RUBIO EDUARDO , CASADO ANTONIO
Published: May 2023

Background/Aim: In patients with advanced platinum-resistant ovarian cancer we prospectively evaluated whether trabectedin could resensitize the tumor cells to platinum rechallenge. Patients and Methods: Upon progression to platinum-based chemotherapy, trabectedin was administered as a 3-hour infusion every three weeks and subsequently crossed over to carboplatin/carboplatin-based combinations. The primary endpoints comprised objective response rate (ORR) and time to progression after trabectedin (TTP Trab). Secondary endpoints included ORR following platinum post-trabectedin, the growth modulation index (GMI) assessed as the ratio of successive TTP to platinum, given after (TTP2) and before (TTP1) trabectedin, quality of life (QoL), and ancillary translational studies. Results: Ten patients with platinum-resistant ovarian cancer from a single institution were treated with trabectedin, one of whom achieved a partial response (PR) reaching the ORR of 10% and six had stable disease (SD) for a disease control rate (DCR) of 70%. After the treatment with platinum post-trabectedin, one patient achieved a PR and two had SD, attaining a rate of resensitization to platinum of 37.5%. The median TTP with trabectedin treatment was 15.0 weeks, while eight patients who received platinum post-trabectedin had the median TTP2 of 19.9 weeks. One patient reached the threshold of GMI >1 (12.5%) as indicator of clinical benefit. QoL of patients was not deteriorated with trabectedin. Predictive biomarkers of response to trabectedin and/or re-exposure to platinum could not be identified. Conclusion: Although trabectedin did not achieve a wide resensitization to platinum in this heavily pretreated platinum-resistant population, a significant number of patients attained disease control.
Prognostic Significance of Immune-related Adverse Events in Metastatic Renal Cell Carcinoma Patients Treated With Immune-checkpoint-inhibitors
Authors: YASUDA YOSUKE , FUJIWARA RYO , OGUCHI TOMOHIKO , KOMAI YOSHINOBU , NUMAO NOBORU , YAMAMOTO SHINYA , OKI RYOSUKE , URASAKI TETSUYA , TAKAHASHI SHUNJI , YONESE JUNJI , YUASA TAKESHI
Published: May 2023

Background/Aim: Immune-related adverse events (irAEs) develop in a subset of patients with metastatic renal cell carcinoma (mRCC) treated with immune-checkpoint-inhibitors (ICIs). Evidence regarding the prognostic impact of irAEs remains limited in these patients. Patients and Methods: Ninety-one consecutive patients with mRCC treated with ICIs were retrospectively analyzed. Overall survival (OS) rates were estimated using the Kaplan–Meier method. In multivariate analysis, predictors of OS were analyzed using the Cox-proportional-hazards-model. Results: Twenty-nine patients were treated with the combination of nivolumab plus ipilimumab. According to International Metastatic RCC Database Consortium risk classification, 27/47/17 patients were classified into favorable/intermediate/poor risk categories. The 1, 3, and 5-year OS-rates were 89, 70, and 57%, respectively. A total of 67 irAEs occurred in 44 patients (48%), including 15 patients with grade 3-4. OS was significantly longer in patients with irAEs (p=0.01). In multivariate analysis, Karnofsky performance status, prior nephrectomy, and irAEs were independent significant predictors of OS. Conclusion: In our study, irAEs were significantly associated with OS in mRCC patients treated with ICIs.
Prognostic Value of Peritoneal Lavage Cytology in Potentially Resectable Pancreatic Cancer Stratified by Cytologic Status
Authors: ISHIDA HIROYUKI , OGURA TOSHIRO , TAKAHASHI AMANE , KITAMURA KEI , MIYAMOTO RYOICHI , MATSUDAIRA SHINICHI , TANABE MINORU , KANDA HIROAKI , KAWASHIMA YOSHIYUKI
Published: May 2023

Background/Aim: Patients with pancreatic ductal adenocarcinoma (PDAC) with positive peritoneal lavage cytology (CY) reportedly have poor prognoses. However, the value of diagnosis of suspicious for malignancy on CY is unknown. This study aimed to elucidate the prognostic impact of CY by focusing on CY subgroups. Patients and Methods: Data were collected from 231 resectable PDAC patients who underwent curative-intent resection. Patients were divided into three CY-based groups: negative (CY0), suspicious for malignancy (CY-S), and positive (CY1). Clinicopathological characteristics and prognostic factors were analyzed. Results: CY1 and CY-S were diagnosed in 7.8% and 3.9% of the patients, respectively. The CY1 group had significantly larger tumors and higher frequencies of distal tumors, anterior pancreatic tissue invasion, retropancreatic tissue invasion, and R1 resection than the CY0 group. Patient characteristics did not differ between the CY0 and CY-S groups. The CY1 group exhibited worse survival than the CY0 and CY-S groups (median survival time: 18.8 vs. 39.6 months, p=0.0021 and vs. 62.2 months, p=0.018). Multivariate analysis for survival indicated that a tumor size >2 cm, preoperative CA19-9 value >100 U/ml, CY1, lymph node metastasis, R1 resection, and lack of adjuvant chemotherapy were associated with poor prognosis. Both the CY1 and CY-S groups had higher frequencies of peritoneal recurrence than the CY0 group (50% vs. 11.8%, p<0.001 and 44.4% vs. 11.8%, p=0.019). Conclusion: The prognosis of the CY1 group was poor. Although CY-S was associated with a higher frequency of peritoneal recurrence than CY0, the long-term outcomes of patients with surgical treatment were acceptable.
Clinical Features of Borderline Ovarian Seromucinous Tumor
Authors: NAGAYOSHI YOKO , YAMADA KYOSUKE , KIYOKAWA TAKAKO , FUKASAWA NEI , KURODA TAKAFUMI , NOGUCHI DAITO , OKAMOTO AIKOU
Published: May 2023

Background/Aim: Ovarian seromucinous tumor is a histological type of ovarian neoplasm. Although seromucinous borderline tumors (BSMT) are associated with endometriosis, the frequency of their occurrence is low, and many aspects of their behavior remain unclear. In this study, we aimed to clarify the clinicopathological factors of BSMT. Patients and Methods: We retrospectively reviewed 32 patients with pathologically diagnosed BSMT who underwent surgery at Jikei University Hospital. The survey items were patient characteristics, such as age, initial symptoms, preoperative tumor markers, surgical procedure and stage of surgery, presence of endometriosis, and recurrence. Results: The median age was 45 years. Lower abdominal pain was the most common chief complaint, about one-third of patients were asymptomatic; one-sixth were discovered during follow-up for endometriosis. The majority had a high serum CA19-9 level. Twenty-five patients (78.1%) had unilateral masses, whereas seven patients (21.9%) had bilateral masses. More than 90% of the cases had coexisting endometriosis histologically. Thirty cases (93.8%) were stage I, only two were stage II, and none were stage III or IV. Recurrence was observed in two cases: one was borderline malignant and the other was a carcinoma. Conclusion: BSMT is a rare form of borderline malignancy. Its preoperative diagnosis is often difficult because of various clinical findings, but a history of endometriosis and an elevated serum CA19-9 level may aid in some cases.
Predicted Configuration and Stability of the ATAD2/SOX10 Complex Using Molecular Dynamics Simulations
Authors: LEHRER STEVEN , RHEINSTEIN PETER H.
Published: May 2023

Background/Aim: ATAD2, a melanoma competence factor, forms a protein complex with SOX10 that facilitates expression of SOX10 developmental target genes. The complex enables a strong transcriptional response to oncogenes such as BRAFV600E and is sufficient to endow oncogenic competence to melanocytes. The elucidation of the ADAT2/SOX10 complex structure may facilitate the development of drugs that can block formation of the complex. Materials and Methods: We used the ClusPro web server for protein-protein docking to visualize and analyze the complex and GROMACS to perform molecular dynamics simulations. Results: ClusPro protein docking analysis demonstrated the central position of ADAT2 in the ADAT2/SOX10 complex. Molecular dynamics simulations of ATAD2 docked to SOX10 suggest that ATAD2/SOX10 is not a stable structure. Conclusion: The central position of ADAT2 in the complex suggested that ADAT2 complexed to SOX10 may have the capability to modify multiple functions of the latter, one of which allows BRAFV600E to impart increased oncogenic function to melanocytes. The results of the molecular dynamics simulations imply that the ADAT2/SOX10 complex is not stable and might be disrupted by a therapeutic molecule, reducing the risk of melanoma. Knowledge of the ADAT2/SOX10 complex structure may facilitate the development of drugs that can block complex formation.
The Gap Between AI and Bedside: Participatory Workshop on the Barriers to the Integration, Translation, and Adoption of Digital Health Care and AI Startup Technology Into Clinical Practice (Preprint)
Authors: Olaye Iredia M , Seixas Azizi A
Published: May 2023

BACKGROUND

Artificial intelligence (AI) and digital health technological innovations from startup companies used in clinical practice can yield better health outcomes, reduce health care costs, and improve patients' experience. However, the integration, translation, and adoption of these technologies into clinical practice are plagued with many challenges and are lagging. Furthermore, explanations of the impediments to clinical translation are largely unknown and have not been systematically studied from the perspective of AI and digital health care startup founders and executives.

OBJECTIVE

The aim of this paper is to describe the barriers to integrating early-stage technologies in clinical practice and health care systems from the perspectives of digital health and health care AI founders and executives.

METHODS

A stakeholder focus group workshop was conducted with a sample of 10 early-stage digital health and health care AI founders and executives. Digital health, health care AI, digital health–focused venture capitalists, and physician executives were represented. Using an inductive thematic analysis approach, transcripts were organized, queried, and analyzed for thematic convergence.

RESULTS

We identified the following four categories of barriers in the integration of early-stage digital health innovations into clinical practice and health care systems: (1) lack of knowledge of health system technology procurement protocols and best practices, (2) demanding regulatory and validation requirements, (3) challenges within the health system technology procurement process, and (4) disadvantages of early-stage digital health companies compared to large technology conglomerates. Recommendations from the study participants were also synthesized to create a road map to mitigate the barriers to integrating early-stage or novel digital health technologies in clinical practice.

CONCLUSIONS

Early-stage digital health and health care AI entrepreneurs identified numerous barriers to integrating digital health solutions into clinical practice. Mitigation initiatives should create opportunities for early-stage digital health technology companies and health care providers to interact, develop relationships, and use evidence-based research and best practices during health care technology procurement and evaluation processes.
Hydrogel Preparation from Shrimp Shell-Based Chitosan: The Degree of Crosslinking and Swelling Study
Authors: Barleany Dhena Ria , Jayanudin Jayanudin , Nasihin Nasihin , Widiawati Mela , Yulvianti Meri , Sari Denni Kartika , Gunawan Akbar
Published: May 2023

Chitosan is a natural polymer derived from different starting materials such as fish scales, crab and shrimp shells. Due to the advantages like biocompatibility and biodegradability, chitosan has been widely used in hydrogel development. This current study aims to make chitosan from shrimp shells, synthesize hydrogel from chitosan, and observe the effect of various chitosan preparation treatments on the properties of the hydrogel. The preparation of chitosan was carried out through demineralization, deproteinization, and deacetylation process. HCl concentration during demineralization and NaOH concentration during deproteinization were varied (1; 1,5; 2) M and (1; 1,5; 2) M, respectively. Chitin deacetylation was conducted using 60% (w/v) of NaOH at the temperature of 90oC for 120 min, and chitosan was resulted. Chitosan based hydrogel was then synthesized with the addition of alginate and glutaraldehyde. The effect of HCl and NaOH concentrations during demineralization and deproteinization on the deacetylation degree of chitosan was observed. The effect of deacetylation degree of chitosan on the degree of crosslinking and swelling property of the hydrogel were also evaluated. Chitosan resulted from this study has the optimum degree of deacetylation at 57.28 %, resulting from demineralization by using HCl 2M and deproteinization with NaOH2 M. Higher deacetilation degree of chitosan causing the increase of the degree of cross-linking and decrease of the swelling capacity of the hydrogel. The highest degree of cross-linking is 78.85 %, and the swelling capacity is 47 %.
Transisi Agraria dan Ketenagakerjaan Pedesaan: Studi Kasus Akuisisi (Perampasan) Tanah untuk Pangan-Energi dan Peluang Bekerja Pemuda di Pedesaan Indonesia
Authors: Yusuf Muhammad
Published: May 2023

Indonesia merupakan salah satu negara di dunia dengan laju perubahan tata guna lahan yang cukup tinggi. Kondisi tersebut ditandai dengan laju deforestrasi baik disebabkan oleh pemberian konsesi penebangan hutan maupun pembangunan perkebunan sawit skala luas. Proses akuisisi tanah dan penyingkiran petani tidak hanya disebabkan oleh prosesproses pelibatan investasi korporasi namun dapat terjadi di tingkat komunitas. Dari hasil pengkajian di salah satu desa di Sulawesi Tengah menunjukkan proses akumulasi lahan saat terjadi booming kakao menyebabkan perbedaan status ekonomi semakin melebar antar warga dalam satu desa. Praktik perkebunan menunjukkan penyerapan rendah terhadap tenaga kerja lokal sekitar perkebunan. Hal ini menjadikan petani sekitar putus hubungan dengan tanah menjadi tenaga kerja bebas. Selain itu juga tidak terintegrasinya ekonomi warga dengan sistem ekonomi perkebunan dan pada saat yang bersamaan tekanan akan kebutuhan pekerjaan berbasis tanah kian mendorong petani menggarap areal perkebunan. Fakta menurunnya minat pemuda pedesaan yang bekerja di pertanian muncul karena semakin jauhnya pengetahuan pertanian, penurunan kualitas pertanian dan kehidupan di desa, perampasan lahan oleh korporasi besar dan sulitnya akses terhadap lahan.Kata Kunci: lahan,desa,pemuda.
Pemaknaan Kaum Muda Mengenai Peran Orang Tua Pada Masa Transisi Pemuda ke Dunia Kerja di Yogyakarta
Authors: Fernanda Stella Elizabeth
Published: May 2023

Pada era late modernity, pemuda dihadapkan dengan situasi transisi menuju dunia kerja yang penuh dengan risiko dan ketidakpastian. Hal ini menimbulkan keresahan tersendiri bagi pemuda, mereka dituntut merespons segala situasi secara cepat dan strategis. Disini lah pemuda membutuhkan orang tua sebagai support system untuk membimbing dan mendampingi pemuda menghadapi masa transisi melalui penerapan pola pengasuhan yang ideal. Penelitian ini bertujuan untuk melihat peran orang tua dalam masa transisi pemuda menuju dunia kerja melalui perspektif pemuda. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan fenomenologi. Adapun informan dalam penelitian ini merupakan lima pemuda yang berstatus sebagai mahasiswa dari beberapa perguruan tinggi di Kota Yogyakarta. Hasil penelitian ini menunjukkan bahwa tidak semua pemuda mendapatkan support system dari orang tua karena penerapan pola pengasuhan yang kurang tepat. Padahal, pemuda sangat membutuhkan support system dari orang tuanya dalam menghadapi tantangan-tantangan sulit dalam proses transisi. Pola pengasuhan berimplikasi terhadap kematangan pemuda dalam merespons risiko transisi sehingga diperlukan pola asuh yang tepat guna mendukung keberhasilan transisi pemuda menuju dunia kerja. Di sisi yang lain, pemuda telah memiliki bayangan pola asuh yang dinilai relevan untuk diterapkan di era modernitas lanjut.
Impact of Extracurricular Activities on Secondary Level Students' Academic Performance
Authors:   Assistant Professor, Department of Education, Annamalai University,Annamalainagar, Tamilnadu, India-608002,, S Venkataraman , A Dheivamani ,   Assistant Professor, Government College of Education Gandhi Nagar, Vellore - 632 006 Tamil Nadu, India
Published: May 2023

This research paper sought to investigate the impact of extracurricular activities onsecondary level students. Through a comprehensive review of the literature, it wasrevealed that extracurricular activities provide a number of benefits to students at the secondary level. These benefits include improved academic performance, increased social skills, better time management skills, and improved self-esteem. Furthermore, the findings suggest that participation in extracurricular activities canhelp to reduce the risk of negative behaviors such as substance abuse, delinquency, and violence. The study concluded that there is a positive relationship betweeninvolvement in extracurricular activities and academic success and that schoolsshould prioritize extracurricular activities for their students.
Social perception of play counseling through big data analysis
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Jung Eun
Published: May 2023

Objectives This study explored the current state of social perception of play counseling through big data analysis. This study tried to understand how play counseling is socially understood and what strategies are needed for the development of play counseling.
Methods Texts such as various blogs, cafes, news, and web documents were collected from five platforms: Naver, Daum, Google, You Tube, and Twitter, with “play+counseling’ as the keyword. The analysis target was limited to the data of the last three years from January 1, 2020 to December 31, 2022. For data analysis, key word frequency analysis, TF-IDF analysis, semantic network analysis, and CONCOR analysis were applied.
Results As the result of frequency analysis and TF-IDF analysis, ‘children’, ‘play’, ‘counseling’, ‘research’, ‘effect’, and ‘expert’ appeared as the top keywords of play counseling. As a result of semantic network analysis, the keyword with the strongest influence was ‘children’. As a result of the CONCOR analysis, the keywords for play counseling formed five clusters. These were named ‘goals and effects of play counseling’, ‘program elements of play counseling’, ‘certification of play psychological counselors’, ‘teacher training for play counseling’, and ‘elementary school’.
Conclusions The perception of play counseling, which is mainly concentrated in elementary school, should be expanded to middle and high school students. Play counseling should be used to cultivate sociality and positive emotions in Korean children and adolescents.
Domestic Research Trends Related to University Freshman's Adaptation to School Life
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Cho Bo ram
Published: May 2023

Objectives This study aims to suggest the direction of future research by analyzing domestic research trends related to university freshman adaptation to school life.
Methods This study was conducted from May 2022 to August 2022, and 57 domestic journals were selected and the study period, research subject, research type, data collection method, research content, and trends in related variables were analyzed.
Results First, research related to college freshman adaptation to school life continues to increase, and the most research was conducted in 2019. Second, as for the trends by study subject, there were many studies targeting freshmen at four-year colleges. Third, in the trend by research type, quantitative research was carried out the most. Fourth, the use of questionnaire method was high in the trend by data collection method. Fifth, as for the trend by research content, the study on the relationship between related variables showed the highest at 64.9%. Sixth, in the trend by related variable, education program, academic self-efficacy, major selection motivation, and college life adaptation were used as independent variables, and career decision self-efficacy and social support were used as mediating variables. As a dependent variable, college life adaptation was mainly used.
Conclusions This study is meaningful in that it examines domestic research trends related to school life adaptation of college freshmen and suggests directions and implications for future studies related to school life adjustment.
A Study on the Plans of Music Education through Martin Seligman's Positive Psychology
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee HyunSu
Published: May 2023

Objectives For the purpose of restoring the value of music education and forming citizens who can express the arts as a society Positive psychology was reviewed and a plan to apply it to music education was presented.
Methods The background of the emergence of positive psychology and the concepts and contents of Optimism Learning, Strengths Development, Well-being Theory, and Flourish, which constitute positive psychology, were explored, typified, and considered. Based on this, a plan that can be used for music education was presented.
Results As a result first, the degree of optimism of learners for music classes is identified in the form of a basic survey, second, it can be used as a survey of learners' musical strengths, third, a method of reconstructing music classes by reflecting on strengths, and fourth, a way to examine learners' happiness after class using the well-being theory was presented in the form of checks and descriptions.
Conclusions In the current educational environment, the proposal of a music education plan using positive psychology for educational practice for learners to discover music emotion and make it strength through music education shows another possibility.
Early childhood teachers' experience of literature education for young children in play-centered curriculum
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lim Yeji
Published: May 2023

Objectives The purpose of this study is to explore the experience of how early childhood teachers conduct literature education for young children in a play-centered curriculum.
Methods The participants in this study were 20 early childhood teachers working at an early childhood education institution in Gyeonggi-do, who were taking the ｢Literature Education for Young children｣ course at the Graduate School of Education of A University. The participants collected reflective journals about what they experienced and felt about literature education for young children while implementing the play-centered curriculum, analyzed the data, and then qualitatively analyzed it.
Results As a result of analyzing the experience of literature education for young children in the play-centered curriculum, firstly, the early childhood teachers supported the environment for early childhood literature in the play-centered curriculum. Second, early childhood teachers made efforts to conduct literature education for young children while operating a play-centered curriculum. Depending on the teacher's personal background and the situation of the institution, the importance of literature education in the curriculum varied, and literature education was carried out independently from the curriculum, or play and literature education for young children were linked or operated in harmony.
Conclusions Based on the results of this study, early childhood teachers' experiences in literature education for young children and their thoughts were examined. This study has significance in providing the necessary basis for early childhood teachers to seek ways to implement substantial literature education for young children and to promote the quality improvement of literature education for young children in the field.
The Effect of Positive Language Programon peer relationshipsss and Class Cohesiveness of Elementary School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yoon Hee Sang
Published: May 2023

Objectives The purpose of this study is to verify the effect of positive language programs on peer relationshipsss and class cohesiveness in elementary school.
Methods To this end, two classes whose homogeneity was confirmed were assigned to the experimental group and the control group, respectively, by conducting a preliminary examination of the peer relationshipss scale and class cohesiveness scale in the 6th grade classes of the elementary school located in Seongnam-si, Gyeonggi-do. The positive language program applied to the experimental group consisted of a total of 8 sessions. After the program was completed, the same post-test as the pre-test was conducted on the experimental group and the control group, and the analysis was performed as an independent sample t-test and a paired sample t-test through SPSS 28.0.
Results The results of the study are as follows. First, the experimental group's peer relationship post-score (M=4.02) applying the positive language program improved than the control group's post-score (M=3.25) and showed a significant effect (p<.001). Second, the experimental group's post-class cohesion score (M=3.83) applying the positive language program improved from the control group's post-score (M=3.34) and showed a significant effect (p<.05).
Conclusions It was confirmed that the positive language program used in this study had a positive effect on peer relations and class cohesiveness in elementary school. In addition, this study is meaningful in that it applied a positive language program to improve peer relationshipsss and class cohesiveness of elementary school students who have experienced crises due to the COVID-19 situation over the past few years.