bluuebunny/crossref_metadata_2025 huggingface dataset:
Sosialisasi Menabung Sejak Dini Pada Anak-Anak Desa Tebing Penyamun Kepahiang
Authors: Fitranita Vika , Wijayanti Indah Oktari , A'yun Qurrata
Published: April 2024

This activity aims to train children in Tebing Penyamun Village to get used to saving money and get used to not being wasteful. service method with demonstration, lecture, and discussion methods. This activity was carried out for 15 children in Tebing Penyamun village, Kepahiang Regency, researchers found a lack of understanding of children in Tebing Penyamun village of the importance of getting used to saving money from an early age. After direct observation in the field, children who were previously uninterested and did not understand the importance of saving from an early age understood and began to want to save. The results showed that children's understanding of early saving increased when compared to before the socialization. Thus, the socialization of early saving can be considered successful to familiarize children to save money.
Pelatihan Visualisasi Data Bagi Siswa SMKS Katolik Kefamenanu
Authors: Chrisinta Debora , Simarmata Justin Eduardo , Mone Ferdinandus
Published: April 2024

The data visualization training program held at SMKS Katolik Kefamenanu was carried out based on the need for a better understanding in managing data, especially among students. This community service aims to provide a deeper understanding of data visualization and technology integration in education. The implementation method includes material preparation, hands-on training sessions, and prates and post-test evaluations. The service results showed a significant increase in students' understanding of data visualization concepts, increased skills in using Microsoft Excel, and increased student interest in data analysis. Students also successfully apply the acquired skills in a practical context.
EFEKTIVITAS PENGGUNAAN FITUR QR CODE DALAM MENGHIMPUN DANA ZIS DI LAZISNU KUDUS
Authors: Fatmawati Putri Oktaviani , Qomar Mohammad Nurul
Published: April 2024

Perkembangan teknologi membawa perubahan bagi sistem pembayaran yang dulu menggunakan uang tunai menjadi sistem non tunai. Hal ini membawa pengaruh bagi lembaga-lembaga zakat terkhusus LAZISNU yang mengikuti perkembangan zaman dengan menggunakan QR Code sebagai salah satu media penyaluran. Akan tetapi dalam penggunaan QR Code terdapat masalah-masalah yang muncul, dikarenakan keterbatasan pengetahuan masyarakat terhadap teknologi masih minim, di mana mereka masih belum tahu cara bagaimana menggunakan QR Code dan bagaimana cara mengukur efektif tidaknya. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas dari penggunaan fitur QR Code di LAZISNU dalam menghimpun dana zakat, infak dan sedekah. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan pendekatan studi kasus. Hasil penelitian ini menunjukkan bahwa penggunaan QR Code di LAZISNU bisa dikatakan efektif. Akan tetapi minimnya pengetahuan dan penyebaran yang tidak merata menjadikan QR Code masih belum banyak dikenal masyarakat. Sehingga penggunaan kaleng INUK masih menjadi prioritas masyarakat.
Analisis Potensi Pengembangan Wisata Halal: Studi Kasus pada Wisata Alam Sumbermaron
Authors: Rozi Ahmad Fahrur , Anam Ahmad Khoirul
Published: April 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis potensi pengembangan wisata halal pada destinasi Wisata Alam Sumbermaron Desa Karangsuko, Kecamatan Pagelaran, Kabupaten Malang. Penelitian ini menggunakan metode deskriptif kualitatif. Hasil penelitian menunjukkan bahwa aspek pengembangan wisata terjadi perkembangan yang cukup baik, terbukti dengan adanya peningkatan jumlah kunjungan wisatawan setiap tahunnya. Potensi pengembangan wisata halal yang dianalisis berdasarkan indikator dari Global Muslim Travel Index (GMTI) terdapat beberapa indikator yang cukup berpotensi seperti dari aspek layanan di mana layanan yang ada pada destinasi wisata telah sesuai dengan konsep layanan dalam Islam. Adapun aspek peluang dan tantangan dalam pengembangan wisata halal yaitu secara geografis terletak pada kawasan pondok pesantren yang dapat dijadikan peluang dalam pengembangan wisata halal, Adapun dalam tantangan yakni belum adanya labelisasi halal pada makanan dan minuman yang dijual, terkait fasilitas ibadah yang belum sesuai dengan standar pengembangan wisata halal, hal tersebut dikarenakan masih minimnya pengetahuan masyarakat mengenai konsep wisata halal.
A Tale of the Two Economic Systems: Institutional Perspective of Chinese Outward FDI
Authors: Li Yuanyuan , Crews Marcus I.
Published: April 2024

State-owned multinational enterprises (SOMNEs) constitute a substantial portion of Chinese outward foreign direct investment (FDI). From an institutional affiliation perspective, this paper examines the differences in the two economic systems (state-owned vs. privately owned) for engaging in outward FDI. Leveraging a sample of Chinese outward FDI projects between 2004 and 2018, we conduct analysis on FDI frequency, location choices, and FDI motives. We also consider the moderating effects of the temporal and space dimensions. The results inform us that the two economic systems are complementary in promoting outward FDI from the home country.
An Empirical Assessment of IAS 40 Investment Property
Authors: Dong Chengjie , Tan Yuxuan , Wang Zhemin , Zhang Yuan
Published: April 2024

This study examines the value relevance of the fair value model versus the cost model for evaluating investment properties under IAS 40 Investment Property. Contrary to the popular belief that fair value is the most relevant measurement attribute, we find that the coefficient estimate of investment properties for Chinese companies that adopted IAS 40’s fair value model is significantly smaller than its theoretical value, and is not significantly different from zero, suggesting that reported fair values are not value relevant as perceived by investors for the sample firms. Furthermore, investors tend to adjust the valuation of fair value companies’ non-investment property assets downward. The findings do not support the claim that fair value is superior to historical cost for the investment property valuation. Our findings highlight the need for more implementation guidelines from the IASB to enhance the value relevance of fair value estimates under IAS 40.
Non-Neovascular Subretinal Fluid with Serous Retinal Pigment Epithelial Detachment: Wait or Treat
Authors: Fawwaz Almamoori , Hajjaj Amer
Published: April 2024

Introduction: To describe the course of subretinal fluid (SRF) in eye with serous pigment epithelial detachment (serous PED) in the absence of macular neovascularization (non-neovascular AMD). Method: This is a retrospective case study included one eye with non-neovascular SRF associated with serous PED. Swept source optical coherence tomography (SS-OCT) and optical coherence angiography (OCTA) were obtained at baseline and follow up with qualitative and quantitative analysis of macula, pigment epithelial detachment (PED), subretinal fluid (SRF) and the presence or absence of macular neovascular membrane (MNV) in addition to other multimodal imaging modalities like fluorescein angiography (FA) and fundus auto fluorescence (FAF). Results: Our 66-year-old female has presented with left serous (PED) with apical (SRF) and no MNV on OCTA with baseline best corrected vision (BCVA) in Log MAR = 0.5. The SS-OCT, OCTA, and BCVA were stable over the initial five-month follow-up observation period with no MNV (non-neovascular SRF). One month later, the patient received an intravitreal anti-VEGF injection outside our clinic. 1-month post-outside clinic anti-VEGF injection, SS-OCT showed a small RPE tear with flattening of RPE detachment and preservation of BCVA =0.5. In the 3rd month post-outside clinic anti-VEGF injection, the SS-OCT showed slight flattening of RPE detachment with an obvious increase in SRF, still negative MNV on the OCTA associated with a drop in BCVA to 0.3. The decision was made to give the patient an initial three loading doses of aflibercept injections .The SS-OCT post 2nd aflibercept injection showed complete resolution and drying out of SRF, with an improvement of BCVA to 0.5. we continue completing the loading phase and then the patient was placed on treat and extend regimen (T&E). After the fifth aflibercept injection, the PED was completely flattened with appearance of MNV on OCTA after resolution of SRF. Conclusion: Many published studies provide preliminary data about non-neovascular AMD with SRF. SRF could be present in the absence of MNV due to RPE decompensation or RPE pump failure. However, the non-neovascular SRF could be transformed with time into a neovascular one with the presence of MNV. Multimodal imaging approach is essential in differentiating non-neovascular versus neovascular SRF and avoiding unnecessary antiVEGF injections.
DİŞ HEKİMLİĞİ ÖĞRENCİLERİNİN ERGONOMİ İLİŞKİLİ KAS-İSKELET SİSTEMİ SORUNLARI, KİNESTEZİ VE TÜKENMİŞLİK DÜZEYLERİ: CİNSİYETE ÖZGÜ FARKLILIKLAR
Authors: Ergan Mesut , Ercan Sabriye , İnce Parpucu Tuba , Başkurt Ferdi , Başkurt Zeliha
Published: April 2024

Amaç: Bu çalışmanın amacı, diş hekimliği öğrencilerinin ergonomik risk seviyelerinin, mesleki kas-iskelet sistemi sorunlarının, kinestezi farkındalıkları ve tükenmişlik seviyelerinin belirlenmesi ve bu durumun cinsiyete özgü farklılıklarının irdelenmesidir.

Yöntem: Kesitsel bir araştırma olarak planlanan bu çalışma XXX Üniversitesi Diş Hekimliği Fakültesinde öğrenim gören 80 öğrencinin katılımıyla gerçekleştirildi. Araştırmanın verileri, Sosyo–Demografik Veri Formu, Cornell Kas İskelet Rahatsızlık Skalası, Modifiye Hızlı Üst Ekstremite Değerlendirme Formu, Kinestezi ve Proprioseptif Farkındalık Anketi ve Maslach Tükenmişlik Ölçeği kullanılarak toplandı. Verilerin istatistiksel analizinde, tanımlayıcı istatistikler kullanıldı. Normal dağılıma uygunluk Shapiro-Wilk testi ile analiz edildi. Bağımsız gruplara göre yapılan karşılaştırmalarda Mann Whitney U testi ve kategorik değişkenler arasındaki ilişkilerin tespit edilmesi için Monte Carlo düzeltmeli ki-kare analizi kullanıldı. Çalışmada p0,05). Duygusal tükenmişlik ve kişisel başarı alt boyutlarında cinsiyete özgü fark saptanmazken (p>0,05) erkeklerin duyarsızlaşmalarının kadınlara göre yüksek olduğu belirlendi (p=0,006).

Sonuç: Bu çalışma, diş hekimliği öğrencilerinin ergonomik risk seviyelerinin yüksek olduğunu, mesleki kas iskelet sistemi problemlerinin ve tükenmişliğin meslek hayatına başlamadan önce gelişebileceğini göstermektedir. Diş hekimliği öğrencilerine ergonomik eğitimin ve günlük yapılabilecek egzersizlere yönelik derslerin verilmesinin bu problemlerin azaltılmasında yardımcı olabileceği düşünülmektedir.
Presença de contaminantes em águas de abastecimento da cidade de Itu, Estado de São Paulo (SP)
Authors: Carreri Andrea Varsone , Gehrke Flávia de Sousa
Published: April 2024

Introdução: Contaminantes endócrinos (CE) afetam o sistema endócrino de diversos organismos vivos. Dentre as substâncias classificadas como CE, destaca-se o bisfenol-A (BPA) e 17β-estradiol(E2). Esses compostos podem estar presentes em águas de abastecimento de muitas cidades e centros urbanos. Objetivo: Identificar a presença de contaminantes endócrinos nas águas de abastecimento da cidade de Itu, Estado de São Paulo (SP), utilizando Artemia salina como bioindicador. Metodologia: Testes para detecção de CE foram realizados em águas de abastecimento da cidade de Itu/SP, análises das características físico-químicas e testes de citotoxicidade com A. salina. Resultados: Foi constatada citotoxicidade nas águas avaliadas a partir de 10%, indicando uma substância altamente tóxica. Não foi detectado estradiol e bisfenol-A nas amostras durante as estações do verão e inverno de 2021. Conclusão: Destaca-se a importância da existência de parâmetros para a qualidade da água para os CE na legislação brasileira vigente, quanto à qualidade da água, ou seja, é necessário reavaliar e estabelecer padrões novos de potabilidade para consumo, levando-se em conta que estas substâncias (CE) são nocivas à saúde mesmo em concentrações muito pequenas.
Levantamento epidemiológico dos pacientes submetidos à cirurgia cardiovascular no município de Parnaíba
Authors: Bezerra Reinaldo da Silva , Bezerra Daniela Machado , Seabra Carlos Alberto Monteiro , Bezerra Rian da Silva , Beltrão Ilvanete Tavares , Silva Augusto César Beltrão da , Beltrão Renata Paula Lima
Published: April 2024

Objetivo: realizar levantamento epidemiológico abrangente dos pacientes submetidos à cirurgia cardiovascular no município de Parnaíba. Buscou-se analisar e compreender a incidência, distribuição demográfica e fatores de risco associados a essas intervenções cirúrgicas, visando contribuir para o aprimoramento das práticas clínicas e políticas de saúde locais. Metodologia: A pesquisa foi conduzida por meio de uma revisão de literatura abrangente, considerando estudos prévios sobre cirurgias cardiovasculares, epidemiologia cardiovascular e indicadores de saúde. Além disso, realizou-se análise de dados provenientes do Datasus, utilizando informações compiladas de registros hospitalares. Resultados: Os resultados incluem uma descrição detalhada da incidência de cirurgias cardiovasculares na região, destacando características demográficas, como faixa etária e gênero. Assim como identificou possíveis fatores de risco predominantes e sua relação entre as cirurgias cardiovasculares e condições de saúde subjacentes. A revisão de literatura forneceu um contexto amplo, enquanto os dados do Datasus agregaram uma perspectiva local específica. Conclusão: as conclusões deste estudo fornecem subsídios para o aprimoramento de políticas de saúde voltadas para a prevenção, diagnóstico precoce e tratamento eficaz de doenças cardiovasculares em Parnaíba. Além disso, este levantamento epidemiológico contribui para a elaboração de estratégias direcionadas a grupos de risco específicos, promovendo a melhoria da qualidade de vida e a redução da carga de doenças cardiovasculares na comunidade estudada.
Aplicação da metodologia BIM no planejamento de obras: Estudo de caso
Authors: Moraes Vitória Gomes , Bandeira Jorge Luiz Saes , Griepp Liane Porto , Tessaro Alessandra Buss , Mattos Flávia Costa de , Nunes Jorge Luiz Oleinik
Published: April 2024

The construction industry is constantly evolving due to technological advances, rendering the traditional 2D project development methodology obsolete in the face of market demands. Enter Building Information Modeling (BIM), a new methodology that integrates information across all construction stages, eliminating incompatibilities and providing benefits to planning. This study aims to deepen the understanding of how BIM can optimize construction planning, improving coordination and the overall quality of the construction process.This study begins with a detailed roadmap for BIM implementation from conception to planning, covering modeling and quantification. Essential quantification criteria were identified by analyzing budgetary compositions from the National System of Costs and Indexes of Civil Construction (SINAPI). Interrelationships between SINAPI compositions and 3D modeling in Autodesk Revit are explored, highlighting how BIM enhances the construction process. Microsoft Project was utilized for planning as a fundamental auxiliary tool in the BIM context for efficient project management. The study concludes that employing BIM in Construction Planning offers numerous advantages, emphasizing the importance of disseminating the BIM system in the construction industry for improved results in economic, social, and environmental aspects.
EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS
Authors: Sezgin Burcu , Soyseven Murat
Published: April 2024

Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography (GC) and Liquid Chromatography (LC) methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites in environmental water samples.
Material and Method: The evaluation of the methods' environmental impact was performed using National Environmental Methods Index Label (NEMI), Analytical Eco-scale, Analytical GREEnness Metric (AGREE), and Green Analytical Procedure Index (GAPI).
Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.
CORRIGENDUM FOR: Nitric Oxide and Salt Resistance in Dahl Rats: No Role of Inducible NO Synthase
Authors: Zicha J , Řezáčová L , Vaněčková I
Published: April 2024

On the basis of author’s request the publisher of Physiological Research decided to change the license of the article to CC BY license.
CORRIGENDUM FOR: Sex Differences in Blood Pressure, Free Radicals and Plasma Cholesterol Fractions in Ren-2 Transgenic Rats of Various Ages
Authors: Rauchová H , Hojná S , Kadlecová M , Vaněčková I , Chao Y-M , Chan J , Zicha J
Published: April 2024

On the basis of author’s request the publisher of Physiological Research decided to change the license of the article to CC BY license.
Epitranscriptomic regulations in the heart
Authors: Benak D , Kolar F , Hlavackova M
Published: April 2024

RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6-methyladenosine (m6A), N6,2‘-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), pseudouridine (Ψ), 5 methylcytosine (m5C), and inosine (I). Dysregulation of epitranscriptomic machinery affecting these modifications vastly changes the cardiac phenotype and is linked with many cardiovascular diseases such as myocardial infarction, cardiomyopathies, or heart failure. Thus, a deeper understanding of these epitranscriptomic changes and their regulatory mechanisms can enhance our knowledge of the molecular underpinnings of prevalent cardiac diseases, potentially paving the way for novel therapeutic strategies.
Instituto Nacional de Cardiologia perspectiva da telerreabilitação em fisioterapia cardiovascular: uma revisão de literatura
Authors: Pereira Florido Aleandra , Oliveira Moura Daniela , Della Torre de Almeida Baccan Melline , Rosa de Oliveira Claudia
Published: April 2024

Introdução: Segundo a Organização Mundial de Saúde, reabilitação cardíaca é um somatório de atividades necessárias para garantir aos portadores de cardiopatia as melhores condições físicas, mental e social para reinserção deste indivíduo na comunidade levando uma vida ativa e produtiva. A reabilitação reduz a mortalidade relacionada a eventos cardiovasculares e globais, diminui a taxa de hospitalização, com melhora expressiva da qualidade de vida, justificando assim sua recomendação pelas principais sociedades médicas. A Tele reabilitação se apresenta como um modelo alternativo proporcionando uma oportunidade valiosa para aprimorar o engajamento em programas de reabilitação cardíaca. Objetivo: Avaliar a eficácia e segurança de programas de tele reabilitação cardíaca comparados com reabilitação convencional em pacientes com doenças cardiovasculares. Método: A coleta de dados foi realizada em bases de dados eletrônicas, incluindo PubMed, SciELO e BVS. A busca foi conduzida utilizando terminologias médicas, como os descritores da BIREME (Decs) e os Medical Subject Headings (MESH). Foram empregados os descritores em português "Reabilitação cardíaca" e "telerreabilitação", bem como em inglês "Telerehabilitation" e "Cardiac rehabilitation", considerando publicações no período entre 2018 e 2023. Resultados: Foram encontrados 896 artigos, quando aplicados os critérios de exclusão foram selecionados 26 artigos. Conclusão: A tele reabilitação apresenta-se como uma abordagem promissora na reabilitação cardíaca, além de maximizar a adesão ao tratamento, a tele reabilitação cardíaca também demonstra potencial para melhorar os resultados clínicos.
Hebraic, the emerging new variety among Palestinians in Israel: Characteristics and sociolinguistic reflections
Authors: Amara Muhammad
Published: April 2024

Language is not abstracted from reality but responds to emerging changes. Arabic-Hebrew contact among Palestinians in Israel offers a fertile background for a study of sociopolitical conflicts, given the unique civil and national status of Palestinian citizens of Israel, a polity defined and perceived as a Jewish state. The current article focuses on Arabic-Hebrew contact in Israel. More specifically, it describes Hebraic, the formation of a “new variety” – Arabic mixed with Hebrew in the linguistic repertoire of Palestinian Arabs, citizens of Israel. The linguistic characteristics and the motives that led to its creation are described. The sociolinguistic reflections in relation to identity are introduced to provide explanations for its formation and its meaning.
Understanding Anxiety
Authors: Rensi Matthew , Geisler James , Jacques Justin , Silber Charles
Published: April 2024

This study is the first of its kind to diachronically analyze how the use of language surrounding anxiety has changed in each version of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Using corpus linguistic technology, the collocations of the word “anxiety” were analyzed and ranked using log dice to determine the strength of associations both within and across each version of this clinical guide. The results demonstrate that collocations among anxiety are changing with each published manual. In addition, specific diagnoses (i.e., generalized anxiety, separation anxiety, and panic disorder) are in flux over time. Lastly, the interpersonal language associated with anxiety is changing, leading to implications for both researchers and clinicians in the field of mental health.
Determining Science Education Students’ Career Aspirations and Future Career Perspectives: A Narrative Inquiry
Authors:   College of Teacher Education, President Ramon Magsaysay State University, Zambales, Philippines, Rogayan Danilo Villar , Saldivar John Ray V. ,   College of Teacher Education, President Ramon Magsaysay State University, Zambales, Philippines, Basilio Lyka P. ,   College of Teacher Education, President Ramon Magsaysay State University, Zambales, Philippines, Ganalon Niño ,   College of Teacher Education, President Ramon Magsaysay State University, Zambales, Philippines
Published: April 2024

Despite achieving similar college degrees, students venture into different paths post-graduation. Having a career plan with career aspirations and future career perspectives is essential for an individual to have a more straightforward career path. This qualitative narrative inquiry research determined science education students’ career aspirations and future career perspectives. Nineteen college science education students in a state university in Zambales, Philippines, were asked about their written narratives describing their career aspirations and future career perspectives. Data from the participants were subjected to thematic analysis following Braun and Clarke’s (2006) framework. Findings showed that science education students’ career aspirations were (a) to teach and inspire students, (b) to pursue advanced studies, (c) to take licensure examinations, (d) to work abroad, and (e) to shift career. Meanwhile, the science education students’ perspectives toward their career after 10 years were (a) to become successful in the teaching field, (b) inspiring and teaching the students, (c) contented in the chosen profession, and (d) willing to embark on another journey. Based on the findings, researchers recommended the creation of career guidance and career management programs among graduating students to provide more apparent career aspirations and career perspectives among them as they become future professionals.
Individual, Vocational, and Societal Dimensions of Relevance of Science Education
Authors:   D. Uznadze Institute of Psychology, School of Arts and Sciences, Ilia State University, Tbilisi, Georgia, Nino Nino , Marika Marika ,   School of Business, Technology and Education, Ilia State University, Tbilisi, Georgia, Lia Lia ,   D. Uznadze Institute of Psychology, School of Arts and Sciences, Ilia State University, Tbilisi, Georgia
Published: April 2024

The relevance of science education and its individual, societal, and vocational dimensions is important issues for the modern learning and teaching process in many countries. These dimensions are considered based on the data obtained from 1541 Georgian students. The study was conducted within the frames of the international ROSES project. The structure analysis of the ROSES questionnaire was conducted to define scales and individual items, which then were processed accordingly and relevant conclusions were drawn. The study findings reveal that Georgian students from basic and secondary schools demonstrate motivation and interest in learning science, participate in extracurricular activities, use social media for study aims, are concerned about environmental problems, and consider science classes interesting. However, the levels of interest, motivation, and positive attitudes are not high and the correlations between them are weak. The study shows that the vocational and societal dimensions of the relevance of science education are relatively better represented in our sample, but the individual dimension lags behind. Both structural and content findings might serve educators from similar contexts.
The Understanding of Scientific Inquiry by Teachers in Initial Training: A Comparative Study between Brazilian and Portuguese Undergraduates
Authors:   Department of General Biology, Universidade Estadual de Londrina, Brasil, Zompero Andreia Freitas , Tania Tania Aparecida da Silva Klein ,   Department of General Biology, Universidade Estadual de Londrina, Brasil, Isilda Teixeira Rodrigues Isilda Teixeira Rodrigues ,   Department of Education and Psychology, Universidade Trás-osMontes e Alto Douro, Portugal, Adriana Quimentão Passos Adriana Quimentão Passos ,   Department of Education, Secretaria de Estaddo da Educação, Brasil
Published: April 2024

Understanding the relevant aspects of the construction of knowledge in science, as well as the elements that are an essential part of a scientific inquiry, need to be discussed in teacher training courses in the area of natural sciences. This study aimed to identify and classify investigative elements present in the conceptions of undergraduates from a university in Brazil and another in Portugal who will be working in basic education. This is a qualitative study using content analysis to identify categories based on the students’ responses, and a quantitative approach using descriptive statistics to quantify the absolute frequency of each response. The data were obtained during a preparatory course on inquiry teaching given to 30 undergraduates from both countries in 2023 through the analysis of a problem situation involving forensic entomology. The results showed that the most frequent investigative elements present in the students’ answers are the problem, the formulation of hypotheses, the collection, analysis, and interpretation of data, and the conclusion.
Computing formation enthalpies through an explainable machine learning method: the case of lanthanide orthophosphates solid solutions
Authors: Di Napoli Edoardo , Wu Xinzhe , Bornhake Thomas , Kowalski Piotr M.
Published: April 2024

In the last decade, the use of AI in Condensed Matter physics has seen a steep increase in the number of problems tackled and methods employed. A number of distinct Machine Learning approaches have been employed in many different topics; from prediction of material properties to computation of Density Functional Theory potentials and inter-atomic force fields. In many cases, the result is a surrogate model which returns promising predictions but is opaque on the inner mechanisms of its success. On the other hand, the typical practitioner looks for answers that are explainable and provide a clear insight into the mechanisms governing a physical phenomena. In this study, we describe a proposal to use a sophisticated combination of traditional Machine Learning methods to obtain an explainable model that outputs an explicit functional formulation for the material property of interest. We demonstrate the effectiveness of our methodology in deriving a new highly accurate expression for the enthalpy of formation of solid solutions of lanthanide orthophosphates.
Breathing, postural stability, and psychological health: a study to explore triangular links
Authors: Tassani Simone , Chaves Paula , Beardsley Marc , Vujovic Milica , Ramírez Juan , Mendoza Jimena , Portero-Tresserra Marta , González-Ballester Miguel Angel , Hernández-Leo Davinia
Published: April 2024

Objective:

This study aims to test the hypothesis that breathing can be directly linked to postural stability and psychological health. A protocol enabling the simultaneous analysis of breathing, posture, and emotional levels in university students is presented. This aims to verify the possibility of defining a triangular link and to test the adequacy of various measurement techniques.

Participants and Procedure:

Twenty-three subjects (9 females and 14 males), aged between 18 and 23 years, were recruited. The experiment consisted of four conditions, each lasting 3 minutes: Standard quiet standing with open eyes 1), with closed eyes 2), and relaxed quiet standing while attempting deep abdominal breathing with open eyes 3) and with closed eyes 4). These latter two acquisitions were performed after subjects were instructed to maintain a relaxed state.

Main Outcome Measures:

All subjects underwent postural and stability analysis in a motion capture laboratory. The presented protocol enabled the extraction of 4 sets of variables: Stabilometric data, based on the displacement of the center of pressure and acceleration, derived respectively from force plate and wearable sensors. Postural variables: angles of each joint of the body were measured using a stereophotogrammetric system, implementing the Helen Hayes protocol. Breathing compartment: optoelectronic plethysmography allowed the measurement of the percentage of use of each chest compartment. Emotional state was evaluated using both psychometric data and physiological signals. A multivariate analysis was proposed.

Results:

A holistic protocol was presented and tested. Emotional levels were found to be related to posture and the varied use of breathing compartments. Abdominal breathing proved to be a challenging task for most subjects, especially females, who were unable to control their breathing patterns. In males, the abdominal breathing pattern was associated with increased stability and reduced anxiety.

Conclusion:

In conclusion, difficulties in performing deep abdominal breathing were associated with elevated anxiety scores and decreased stability. This depicts a circular self-sustaining relationship that may reduce the quality of life, undermine learning, and contribute to muscular co-contraction and the development of musculoskeletal disorders. The presented protocol can be utilized to quantitatively and holistically assess the healthy and/or pathological condition of subjects.
Deep eutectic solvent-based shaking-assisted extraction for determination of bioactive compounds from Norway spruce roots
Authors: Kalyniukova Alina , Várfalvyová Alica , Płotka-Wasylka Justyna , Majchrzak Tomasz , Makoś-Chełstowska Patrycja , Tomášková Ivana , Pešková Vítězslava , Pastierovič Filip , Jirošová Anna , Andruch Vasil
Published: April 2024

Polyphenolic compounds play an essential role in plant growth, reproduction, and defense mechanisms against pathogens and environmental stresses. Extracting these compounds is the initial step in assessing phytochemical changes, where the choice of extraction method significantly influences the extracted analytes. However, due to environmental factors, analyzing numerous samples is necessary for statistically significant results, often leading to the use of harmful organic solvents for extraction. Therefore, in this study, a novel DES-based shaking-assisted extraction procedure for the separation of polyphenolic compounds from plant samples followed by LC-ESI-QTOF-MS analysis was developed. The DES was prepared from choline chloride (ChCl) as the hydrogen bond acceptor (HBA) and fructose (Fru) as the hydrogen bond donor (HBD) at various molar ratios with the addition of 30% water to reduce viscosity. Several experimental variables affecting extraction efficiency were studied and optimized using one-variable-at-a-time (OVAT) and confirmed by response surface design (RS). Nearly the same experimental conditions were obtained using both optimization methods and were set as follows: 30 mg of sample, 300 mg of ChCl:Fru 1:2 DES containing 30% w/w of water, 500 rpm shaking speed, 30 min extraction time, 10°C extraction temperature. The results were compared with those obtained using conventional solvents, such as ethanol, methanol and water, whereby the DES-based shaking-assisted extraction method showed a higher efficiency than the classical procedures. The greenness of the developed method was compared with the greenness of existing procedures for the extraction of polyphenolic substances from solid plant samples using the complementary green analytical procedure index (ComplexGAPI) approach, while the results for the developed method were better or comparable to the existing ones. In addition, the practicability of the developed procedure was evaluated by application of the blue applicability grade index (BAGI) metric. The developed procedure was applied to the determination of spruce root samples with satisfactory results and has the potential for use in the analysis of similar plant samples.
Enterovirus A71 infection-induced dry eye-like symptoms by damaging the lacrimal glands
Authors: Zhou Nan , Chen Taige , You Qiao , Chen Deyan , Liu Lifei , Hu Kai
Published: April 2024

Purpose

To determine the effects of EV-A71 (Enterovirus A71) infection on ocular surface and its mechanism.

Methods

AG6 mice aged two to three weeks were randomly divided into control and EV-A71 infected groups. Slit-lamp observation, fluorescein staining, and phenol red thread test were used to assess symptoms of ocular surface at 4 dpi (days post infection). The pathological changes of cornea and lacrimal gland were observed by H&E staining, PAS staining, TUNEL assay, IHC staining and qRT-PCR. Corneas and lacrimal glands from mice were obtained and processed for RNA sequencing analysis. Newly diagnosed HFMD patients caused by EV-A71 were recruited and ensured they met the inclusion criteria. Ocular surface parameters (TMH and NIKBUT) were measured using the OCULUS Keratograph 5M. Tear samples were taken to examine Cxcl1 and IL-6 levels through the ELISA method.

Results

Mice studies revealed that EV-A71 infection caused tear film instability, decreased tear secretions, decreased in lacrimal gland size, and distinct goblet cell loss. It also resulted in increased large vacuoles within acinar cells and structural damage in lacrimal gland. Apart from minor damage to the epidermis, there was no obvious inflammatory changes or apoptosis in the cornea. However, there were significant inflammatory injury and apoptosis in the lacrimal gland. RNA-seq analysis showed IL-17 and NF-κB signaling pathways were activated in the lacrimal glands of mice infected with EV-A71. In HFMD patients, the THM was in a low range and NITBUT was significantly shorter than the control group by Oculus Keratograph 5M. ELISA assay showed a higher tear Cxcl1 and IL-6 level in them.

Conclusion

EV-A71 infection affected lacrimal gland structure and function and induced dry eye-like symptoms.
Trajectories of functional and structural myocardial parameters in post-COVID-19 syndrome—insights from mid-term follow-up by cardiovascular magnetic resonance
Authors: Gröschel Jan , Grassow Leonhard , van Dijck Phillip , Bhoyroo Yashraj , Blaszczyk Edyta , Schulz-Menger Jeanette
Published: April 2024

Introduction

Myocardial tissue alterations in patients with post-Coronavirus disease 2019 syndrome (PCS) are often subtle and mild. Reports vary in the prevalence of non-ischemic and ischemic injuries as well as the extent of ongoing myocardial inflammation. The exact relevance of these myocardial alterations is not fully understood. This study aimed at describing the trajectories of myocardial alterations in PCS patients by mid-term follow-up with cardiovascular magnetic resonance (CMR).

Methods

This study entails a retrospective analysis of symptomatic PCS patients referred for follow-up CMR between August 2020 and May 2023 due to mildly affected or reduced left or right ventricular function (LV and RV, respectively) and structural myocardial alterations, e.g., focal and diffuse fibrosis, on baseline scans. Follow-up CMR protocol consisted of cine images and full coverage native T1 and T2 mapping. Baseline and follow-up scans were compared using t-tests or Wilcoxon tests. Post-hoc analysis was carried out in a subgroup based on the change of LV stroke volume (SV) between scans.

Results

In total, 43 patients [median age (interquartile range) 46 (37–56) years, 33 women] received follow-ups 347 (167–651) days after initial diagnosis. A decrease in symptoms was recorded on follow-ups (p < 0.03) with 23 patients being asymptomatic at follow-ups [symptomatic at baseline 43/43 (100%) vs. symptomatic at follow-up 21/43 (49%), p < 0.001]. Functional improvement was noted for LV-SV [83.3 (72.7–95.0) vs. 84.0 (77.0–100.3) ml; p = 0.045], global radial [25.3% (23.4%–27.9%) vs. 27.4% (24.4%–33.1%); p < 0.001], and circumferential strains [−16.5% (−17.5% to −15.6%) vs. −17.2% (−19.5% to −16.1%); p < 0.001]. In total, 17 patients had an LV-SV change >10% on follow-up scans (5 with a decrease and 12 with an increase), with LV-SV, RV-SV, and global longitudinal strain being discriminatory variables on baseline scans (p = 0.01, 0.02, and 0.04, respectively). T1- or T2-analysis revealed no changes, remaining within normal limits.

Conclusion

Symptomatic load as well as blood pressures decreased on follow-up. CMR did not detect significant changes in tissue parameters; however, volumetric, specifically LV-SV, and deformation indexes improved during mid-term follow-up.
Novel portable hypothermic machine perfusion preservation device enhances cardiac viability of donated human hearts
Authors: Andrijauskaite Kristina , Veraza Rafael J. , Lopez Riley P. , Maxwell Zach , Cano Isabella , Cisneros Exal E. , Jessop Israel J. , Basurto Maria , Lamberson George , Watt Michelle D. , Nespral Joseph , Ono Masahiro , Bunegin Leonid
Published: April 2024

Introduction

Heart transplant remains the gold standard treatment for patients with advanced heart failure. However, the list of patients waiting for a heart transplant continues to increase. We have developed a portable hypothermic oxygenated machine perfusion device, the VP.S ENCORE®, to extend the allowable preservation time. The purpose of this study was to test the efficacy of the VP.S. ENCORE® using deceased donors derived hearts.

Methods

Hearts from brain-dead donors not utilized for transplant (n = 11) were offered for research from the Texas Organ Sharing Alliance (TOSA), South and Central Texas' Organ Procurement Organization (OPO) and were preserved in the VP.S ENCORE® for 4 (n = 2), 6 (n = 3), and 8 (n = 3) hours or were kept in static cold storage (SCS) (n = 3). After preservation, the hearts were placed in an isolated heart Langendorff model for reperfusion and evaluated for cardiac function.

Results

The mean donor age was 37.82 ± 12.67 with the youngest donor being 19 and the oldest donor being 58 years old. SCS hearts mean weight gain (%) was −1.4 ± 2.77, while perfused at 4 h was 5.6 ± 6.04, perfused at 6 h 2.1 ± 6.04, and 8 h was 7.2 ± 10.76. Venous and arterial lactate concentrations were less than 2.0 mmol/L across all perfused hearts. Left ventricular contractility (+dPdT, mmHg/s) for 4 h (1,214 ± 1,064), 6 (1,565 ± 141.3), and 8 h (1,331 ± 403.6) were within the range of healthy human heart function. Thus, not significant as compared to the SCS group (1,597 ± 342.2). However, the left ventricular relaxation (mmHg/s) was significant in 6-hour perfused heart (p < 0.05) as compared to SCS. Gene expression analysis of inflammation markers (IL-6, IL-1β) showed no significant differences between SCS and perfused hearts, but a 6-hour perfusion led to a downregulated expression of these markers.

Discussion

The results demonstrate that the VP.S ENCORE® device enhances cardiac viability and exhibits comparable cardiac function to a healthy heart. The implications of these findings suggest that the VP.S ENCORE® could introduce a new paradigm in the field of organ preservation, especially for marginal hearts.
Exploring the multimedia effect in testing: the role of coherence and item-level analysis
Authors: Arts Jorik , Emons Wilco , Dirkx Kim , Joosten-ten Brinke Desirée , Jarodzka Halszka
Published: April 2024

Educational tests often combine text and images in items. Research shows that including images in test items can influence response accuracy, termed the Multimedia Effect in Testing. This effect suggests that using pictures in tests can enhance student performance and reduce the perception of item difficulty. As such, the Multimedia Effect in Testing could influence test validity. However, research in this area has produced varied and conflicting results, which may be partly attributed to the functionality of the images used. Besides, many studies only offer test-level data, making it challenging to determine whether the outcomes represent a generic phenomenon or result from averaging mixed outcomes in individual test items. This present study examined whether coherency of pictures in tests influences response accuracy, mental effort and time-on-task at the test level and item level. Item-level analysis showed that the Multimedia Effect in Testing is not universal; only a small subset of items showed significant differences between text-only and text-picture items. The degree of coherence also did not give unambiguous results. In summary, the study highlights the complexity of the Multimedia Effect in Testing, suggesting it is context-dependent, with not all test items benefiting equally from multimedia elements. The findings emphasize the need for a nuanced understanding of how multimedia affects educational testing.
Establishment and validation of a multivariate logistic model for risk factors of thyroid nodules using lasso regression screening
Authors: Liu Jianning , Feng Zhuoying , Gao Ru , Liu Peng , Meng Fangang , Fan Lijun , Liu Lixiang , Du Yang
Published: April 2024

Objective

This study aims to analyze the association between the occurrence of thyroid nodules and various factors and to establish a risk factor model for thyroid nodules.

Methods

The study population was divided into two groups: a group with thyroid nodules and a group without thyroid nodules. Regression with the least absolute shrinkage and selection operator (Lasso) was applied to the complete dataset for variable selection. Binary logistic regression was used to analyze the relationship between various influencing factors and the prevalence of thyroid nodules.

Results

Based on the screening results of Lasso regression and the subsequent establishment of the Binary Logistic Regression Model on the training dataset, it was found that advanced age (OR=1.046, 95% CI: 1.033-1.060), females (OR = 1.709, 95% CI: 1.342-2.181), overweight individuals (OR = 1.546, 95% CI: 1.165-2.058), individuals with impaired fasting glucose (OR = 1.590, 95% CI: 1.193-2.122), and those with dyslipidemia (OR = 1.588, 95% CI: 1.197-2.112) were potential risk factors for thyroid nodule disease (p<0.05). The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for the Binary Logistic Regression Model is 0.68 (95% CI: 0.64-0.72).

Conclusions

advanced age, females, overweight individuals, those with impaired fasting glucose, and individuals with dyslipidemia are potential risk factors for thyroid nodule disease.
Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field
Authors: Olejarz Michal , Szczepanek-Parulska Ewelina , Ruchala Marek
Published: April 2024

Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment. Some lipoproteins have also been proposed as markers in some endocrine diseases, e.g., thyroid carcinoma. From the scope of endocrine disorders, the largest number of studies explored the lipoprotein changes in polycystic ovary syndrome and in women during the menopausal and peri-menopausal period. Even though the association of thyroid disorders with dyslipidemia is already well studied, new research has delivered some exciting findings about lipoprotein alterations in euthyroid patients with either positive antithyroid peroxidase antibodies or reduced sensitivity to thyroid hormones. The problem of the adverse metabolic profile, including dyslipidemia in hypoprolactinemia has been recognized. Moreover, this review describes other significant discoveries encompassing lipoprotein alterations in disorders of the adrenals, thyroid, parathyroid glands, pituitary, and gonads. The up-to-date knowledge of the influence of endocrine disorders and hormonal changes on serum lipoproteins is prudent as it can significantly impact therapeutic decisions.