bluuebunny/crossref_metadata_2025 huggingface dataset:
Interception Systems in Assessment of Dermal Exposure to Pesticides: Laboratory Comparison of Media
Authors: Barrese Elena , Tranfo Giovanna , Marramao Antonella , Scarpelli Marialuisa
Published: June 2020

Dermal exposure of workers to pesticides can be assessed using patches, placed on the workers’ clothes or used to wipe off the substance from the skin. Since there are no official indications of the materials to be used for patch sampling, a wide range of materials is suggested in the scientific literature. This paper reports a laboratory study on the affinity of four different pesticides widely used in southern Italy with five patch matrices. Imidacloprid, Hexythiazox, Boscalid and Myclobutanil were tested with cotton and gauze sheets, polyethylene tissue and two different grades of cellulose papers. An aerosol machine was used to nebulize the substance on the patches in a closed system, simulating the conditions of use on the workers’ clothes. The recovery of the analytes from the media was evaluated, by spiking the patches with a known amount of each active substance and testing their performances as skin wipes. Samples were extracted and analyzed in gas chromatography with an electron capture detector. The recovery from the spiked patches was 89–96% for all pesticides, while the test recoveries were very different. Results showed a higher affinity with Imidacloprid and Hexythiazox for gauze, with Myclobutanil for cotton and with Boscalid for paper filters (W41).
CHEK2 Mutation in Patient with Multiple Endocrine Glands Tumors. Case Report
Authors: Szeliga Anna , Pralat Aleksandra , Witczak Wiktoria , Podfigurna Agnieszka , Wojtyla Cezary , Kostrzak Anna , Meczekalski Blazej
Published: June 2020

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Case description: In 2005, a 30-year-old woman was admitted to the hospital due to uncontrolled hypertension and obesity. Performed tests have shown ACTH (adrenocorticotropic hormone)—independent micronodular adrenal hyperplasia (AIMAH) as a cause. In 2010, the further diagnostic analysis revealed Cushing’s disease caused by ACTH-secreting pituitary microadenoma. Additionally, in 2011, the patient underwent the strumectomy of multinodular struma. Papillary thyroid carcinoma was found in the excised tissue. In 2018, transvaginal ultrasonography revealed a tumor of the right ovary. After a performed hysterectomy with bilateral salpingo-oophorectomy, the histopathology result has shown female adnexal tumors of probable Wolffian origin (FATWO) located in the broad ligament of the uterus. Due to the history of multiglandular diseases, the patient was referred to genetic testing. We found a positive pathogenic mutation in CHEK2-suppressor gene involved in DNA repair, cell cycle arrest, and apoptosis in response to DNA damage. Conclusion: CHEK2 variants may predispose to a range of endocrine glands tumors, including those identified in our patient. Multiple endocrine glands tumors, as in the presented patient, are a serious problem of public health, due to numerous hospitalizations and necessary repeated surgical treatments. Moreover, the association between CHEK2 and ovarian cancer can be a serious problem with reproductive health.
Spatial Dimension of Unemployment: Space-Time Analysis Using Real-Time Accessibility in Czechia
Authors: Netrdová Pavlína , Nosek Vojtěch
Published: June 2020

This paper focuses on the analysis of unemployment data in Czechia on a very detailed spatial structure and yearly, extended time series (2002–2019). The main goal of the study was to examine the spatial dimension of disparities in regional unemployment and its evolutionary tendencies on a municipal level. To achieve this goal, global and local spatial autocorrelation methods were used. Besides spatial and space-time analyses, special attention was given to spatial weight matrix selection. The spatial weights were created according to real-time accessibilities between the municipalities based on the Czech road network. The results of spatial autocorrelation analyses based on network spatial weights were compared to the traditional distance-based spatial weights. Despite significant methodological differences between applied spatial weights, the resulting spatial pattern of unemployment proved to be very similar. Empirically, relative stability of spatial patterns of unemployment with only slow shift of differentiation from macro- to microlevels could be observed.
Regulation of Three Key Kinases of Brassinosteroid Signaling Pathway
Authors: Mao Juan , Li Jianming
Published: June 2020

Brassinosteroids (BRs) are important plant growth hormones that regulate a wide range of plant growth and developmental processes. The BR signals are perceived by two cell surface-localized receptor kinases, Brassinosteroid-Insensitive1 (BRI1) and BRI1-Associated receptor Kinase (BAK1), and reach the nucleus through two master transcription factors, bri1-EMS suppressor1 (BES1) and Brassinazole-resistant1 (BZR1). The intracellular transmission of the BR signals from BRI1/BAK1 to BES1/BZR1 is inhibited by a constitutively active kinase Brassinosteroid-Insensitive2 (BIN2) that phosphorylates and negatively regulates BES1/BZR1. Since their initial discoveries, further studies have revealed a plethora of biochemical and cellular mechanisms that regulate their protein abundance, subcellular localizations, and signaling activities. In this review, we provide a critical analysis of the current literature concerning activation, inactivation, and other regulatory mechanisms of three key kinases of the BR signaling cascade, BRI1, BAK1, and BIN2, and discuss some unresolved controversies and outstanding questions that require further investigation.
Influence of Thermal Pollution on the Physiological Conditions and Bioaccumulation of Metals, Metalloids, and Trace Metals in Whitefish (Coregonus lavaretus L.)
Authors: Gashkina Natalia A. , Moiseenko Tatyana I.
Published: June 2020

The Kola nuclear power plant, which discharges warm water into one of the bays of subarctic Lake Imandra, significantly changes fish habitats. The temperature gradient of the lake is between 2 and 8 °C, which makes it significantly different from the natural temperature of the lake water. The stenothermal cold-water native species (lake whitefish (Coregonus lavaretus L.)), living for more than 40 years under conditions of thermal pollution, has adapted to this stressor. Moreover, this population differs favorably from the population in the natural-temperature environment in terms of its physiological state. Firstly, the hemoglobin concentrations in the fish blood are in the range of the ecological optimum, and secondly, it has a higher somatic growth, as estimated by Fulton’s condition factor. One of its main adaptive mechanisms of ion regulation is an intense metabolism of Na due to the high respiratory activity of the whitefish in warmer water. An increased accumulation of Rb and excretion of Se, Mo, and Si are associated more or less with that feature. Under conditions of an increased water temperature, the main metabolic need is due to a deficiency of Se in fish. The intensive metabolism of selenoproteins may involve risks of toxic effects and the bioaccumulation of Hg, As, and Cu in cases of increased existing stressors or the appearance of new ones.
Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
Authors: Battram Anthony M. , Bachiller Mireia , Martín-Antonio Beatriz
Published: June 2020

Cellular senescence was first described as a physiological tumor cell suppressor mechanism that leads to cell growth arrest with production of the senescence-associated secretory phenotype known as SASP. The main role of SASP in physiological conditions is to attract immune cells to clear senescent cells avoiding tumor development. However, senescence can be damage-associated and, depending on the nature of these stimuli, additional types of senescence have been described. In the context of cancer, damage-associated senescence has been described as a consequence of chemotherapy treatments that were initially thought of as a tumor suppressor mechanism. However, in certain contexts, senescence after chemotherapy can promote cancer progression, especially when immune cells become senescent and cannot clear senescent tumor cells. Moreover, aging itself leads to continuous inflammaging and immunosenescence which are responsible for rewiring immune cells to become defective in their functionality. Here, we define different types of senescence, pathways that activate them, and functions of SASP in these events. Additionally, we describe the role of senescence in cancer and its treatments, including how aging and chemotherapy contribute to senescence in tumor cells, before focusing on immune cell senescence and its role in cancer. Finally, we discuss potential therapeutic interventions to reverse cell senescence.
Quercetin Attenuates Pancreatic and Renal D-Galactose-Induced Aging-Related Oxidative Alterations in Rats
Authors: El-Far Ali H. , Lebda Mohamed A. , Noreldin Ahmed E. , Atta Mustafa S. , Elewa Yaser H. A. , Elfeky Mohamed , Mousa Shaker A.
Published: June 2020

Aging is an oxidative stress-associated process that progresses with age. Our aim is to delay or attenuate these oxidative alterations and to keep individuals healthy as they age using natural compounds supplementation. Therefore, we conducted the present study to investigate the protective potentials of quercetin against D-galactose (D-gal)-associated oxidative alterations that were induced experimentally in male Wistar rats. Forty-five rats were randomly allocated into five groups of nine rats each. The groups were a control group that was reared on a basal diet and injected subcutaneously with 120 mg D-gal dissolved in physiological saline solution (0.9% NaCl) per kg body weight daily and quercetin-treated groups that received the same basal diet and subcutaneous daily D-gal injections were supplemented orally with 25, 50, and 100 mg of quercetin per kg body weight for 42 days. Pancreatic and renal samples were subjected to histopathological, immunohistochemical, and relative mRNA expression assessments. Aging (p53, p21, IL-6, and IL-8), apoptotic (Bax, CASP-3, and caspase-3 protein), proliferative (Ki67 protein), antiapoptotic (Bcl2 and Bcl2 protein), inflammatory (NF-κB, IL-1β, and TNF-α), antioxidant (SOD1), and functional markers (GCLC and GCLM genes and insulin, glucagon, and podocin proteins) were determined to evaluate the oxidative alterations induced by D-gal and the protective role of quercetin. D-gal caused oxidative alterations of the pancreas and kidneys observed via upregulations of aging, apoptotic, and inflammatory markers and downregulated the antiapoptotic, proliferative, antioxidant, and functional markers. Quercetin potentially attenuated these aging-related oxidative alterations in a dose-dependent manner. Finally, we can conclude that quercetin supplementation is considered as a promising natural protective compound that could be used to delay the aging process and to maintain human health.
Lethal and Sublethal Effects of Methyl Benzoate on the Predatory Bug Nesidiocoris tenuis
Authors: Mostafiz Md Munir , Hassan Errol , Shim Jae-Kyoung , Lee Kyeong-Yeoll
Published: June 2020

Benzoates (naturally occurring plant toxins) produce pesticidal effects on various pest insects and mites, but their effects on non-target insects are poorly understood. In this study, we evaluate the lethal and sublethal toxicity of methyl benzoate (MB) to adults of the generalist predatory bug Nesidiocoris tenuis (Reuter) (Hemiptera: Miridae). To assess lethal effects, N. tenuis was exposed to plant surfaces treated with 0.25%, 0.5% and 1% MB, as well as negative and positive controls (water and the neonicotinoid acetamiprid, respectively). Exposure to 1% MB resulted in the highest corrected mortality of 17.8% and 13.3% under laboratory and greenhouse conditions, respectively. Thus, 1% MB can be classified as harmless to N. tenuis according to the International Organization for Biological Control rating scheme. At the sublethal level, MB exposure did not significantly affect the consumption of eggs of the whitefly Bemisia tabaci by N. tenuis relative to negative control feeding rates. In contrast, acetamiprid at the manufacturer’s recommended concentration reduced N. tenuis feeding activity by 45.4%. Furthermore, in a Y-tube olfactometer assay, there were no significant differences between the olfactory responses of N. tenuis to MB concentrations and the negative control (water). This study therefore suggests that MB could be used safely for pest control in combination with N. tenuis.
MiRNA Expression Profile in the Airways Is Altered during Pulmonary Exacerbation in Children with Cystic Fibrosis—A Preliminary Report
Authors: Stachowiak Zuzanna , Wojsyk-Banaszak Irena , Jończyk-Potoczna Katarzyna , Narożna Beata , Langwiński Wojciech , Kycler Zdzisława , Sobkowiak Paulina , Bręborowicz Anna , Szczepankiewicz Aleksandra
Published: June 2020

MicroRNAs are small non-coding RNAs that regulate immune response and inflammation. We assumed that miRNAs may be involved in the immune response during cystic fibrosis pulmonary exacerbations (CFPE) and that altered expression profile in the airways and blood may underlie clinical outcomes in CF pediatric patients. Methods: We included 30 pediatric patients diagnosed with cystic fibrosis. The biologic material (blood, sputum, exhaled breath condensate) was collected during pulmonary exacerbation and in stable condition. The miRNA expression profile from blood and sputum (n = 6) was done using the next-generation sequencing. For validation, selected four miRNAs were analyzed by qPCR in exosomes from sputum supernatant and exhaled breath condensate (n = 24). NGS analysis was done in Base Space, correlations of gene expression with clinical data were done in Statistica. Results: The miRNA profiling showed that four miRNAs (miR-223, miR-451a, miR-27b-3p, miR-486-5p) were significantly altered during pulmonary exacerbation in CF patients in sputum but did not differ significantly in blood. MiRNA differently expressed in exhaled breath condensate (EBC) and sputum showed correlation with clinical parameters in CFPE. Conclusion: MiRNA expression profile changes in the airways during pulmonary exacerbation in CF pediatric patients. We suggest that miRNA alterations during CFPE are restricted to the airways and strongly correlate with clinical outcome.
Validation of FRIEND and ACSM Equations for Cardiorespiratory Fitness: Comparison to Direct Measurement in CAD Patients
Authors: Jang Won Young , Kang Dong Oh , Park Yoonjee , Lee Jieun , Kim Woohyeun , Choi Jah Yeon , Roh Seung-Young , Jang Yuna , Park Se-Hyun , Kim Woo-Sub , Na Jin Oh , Choi Cheol Ung , Rha Seung-Woon , Park Chang Gyu , Seo Hong Seog , Kim Eung Ju
Published: June 2020

The regression equation of the American College of Sports Medicine (ACSM) was a preferred method for estimating maximal oxygen consumption (VO2max). Recently, a more precise equation from the fitness registry and the importance of exercise national database (FRIEND) for healthy people was developed. This study compared VO2max estimated by the ACSM and FRIEND equations to VO2max directly measured in coronary artery disease (CAD) patients. Overall, 293 CAD patients who participated in cardiac rehabilitation between June 2015 and December 2018 were analyzed. Directly measured VO2max values were compared to the ACSM and FRIEND equations. The directly measured VO2max was significantly different from the estimated VO2max by ACSM equation (24.16 vs. 28.7 mL/kg/min, p < 0.001), which was overestimated by 20% in men and 16% in women. However, there was no statistically significant difference between the directly measured VO2max and the estimated VO2max by the FRIEND equation. (24.16 vs. 24.15 mL/kg/min, p = 0.986). In CAD patients, the estimated VO2max from the ACSM equation was significantly higher than the directly measured VO2max. In addition, estimated cardiorespiratory fitness (CRF) by the FRIEND equation showed similar results with directly measured CRF. As a result, the FRIEND equation can predict CRF more accurately than the ACSM.
Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic
Authors: Maspero Cinzia , Abate Andrea , Cavagnetto Davide , El Morsi Mohamed , Fama Andrea , Farronato Marco
Published: June 2020

Background: COVID-2019 spread rapidly throughout the world from China. This infection is highly contagiousness, has a high morbidity, and is capable of evolving into a potentially lethal form of interstitial pneumonia. Numerous countries shut-down various activities that were considered “not essential.” Dental treatment was in this category and, at the time of writing, only non-deferrable emergencies are still allowed in many countries. Therefore, follow-up visits of ongoing active therapies (e.g., orthodontic treatment) must be handled taking special precautions. This literature review aims at reducing in-office appointments by providing an overview of the technologies available and their reliability in the long-distance monitoring of patients, i.e., teledentistry. Methods: A literature review was made according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. Randomized clinical trials, cross sectional, observational, and case-control studies were evaluated with the Mixed Methods Appraisal Tool for quality assessment and study limitations. Results: A primary search found 80 articles, 69/80 were excluded as non-relevant on the basis of: the abstract, title, study design, bias, and/or lack of relevance. Twelve articles were included in the qualitative analysis. Conclusions: Teleorthodontics can manage most emergencies, reassuring and following patients remotely. The aim set by dental teleassistance was met as it reduced patients’ office visits whilst maintaining regular monitoring, without compromising the results. Although our preliminary findings should be further investigated to objectively evaluate the efficacy, cost-effectiveness, and long-term results, we are confident that teleassistance in orthodontics will have a role to play in the near future.
Should We Continue Assessing Glomerular Filtration Rate with the Cockroft–Gault Formula in NOAC-Treated Patients? The Magnitude of the Problem
Authors: Cemin Roberto , Foco Luisa , Zoccali Carmine , De Caterina Raffaele
Published: June 2020

Despite the proven superiority of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) over the Cockcroft–Gault (CG) formula, current guidelines recommend the latter to assess renal function in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs). To assess the relationship between the CG and the recommended CKD-EPI formulas, in a cohort of atrial fibrillation (AF) patients treated with NOACs, and the misclassifications introduced by the CG formula for renal function levels, we estimated renal function with three equations: CG, CKD-EPI with body surface adjustment (1.73 mL/m2, CKD-EPI) and without such adjustment (CKD-EPI_noBSA), in all consecutive AF patients discharged from NOACs from the Cardiology Division of a main city hospital between February 1st and May 31st 2018. We compared the different estimates of glomerular filtration rate and potential renal function class misclassifications. We reclassified 37/115 patients (32.1%) when switching from the CG to the CKD-EPI; and 24/115 (20.8%) switching from the CG to the CKD-EPI_noBSA formulas. Class reallocation was distributed across all levels of renal function, but mostly affected the “hyper-normal” function. In estimating consequences of such reallocation, a change in NOAC dosages would have occurred in 10/115 patients (8.7%) when switching from the CG to the CKD-EPI formula and in 10/115 patients when switching from the CG to the CKD-EPI_noBSA formula. Although the CG method has been traditionally used to calculate renal function in all NOAC studies, a renal dysfunction class reallocation occurs in a substantial fraction of hospital-admitted AF patients with the use of better estimates of renal function.
Early Respiratory Impairment and Pneumonia after Hybrid Laparoscopically Assisted Esophagectomy—A Comparison with the Open Approach
Authors: Reichert Martin , Lang Maike , Hecker Matthias , Schneck Emmanuel , Sander Michael , Uhle Florian , Weigand Markus A. , Askevold Ingolf , Padberg Winfried , Grau Veronika , Hecker Andreas
Published: June 2020

Patients undergoing esophageal cancer surgery are at high risk of developing severe pulmonary complications. Beneficial effects of minimally invasive esophagectomy had been discussed recently, but the incidence of perioperative respiratory impairment remains unclear. This is a retrospective single-center cohort study of patients, who underwent open (OE) or laparoscopically assisted, hybrid minimally invasive abdomino-thoracic esophagectomy (LAE) for cancer regarding respiratory impairment (PaO2/FiO2 ratio (P/FR) < 300 mmHg) and pneumonia. No differences were observed in the cumulative incidence of reduced P/FR between OE and LAE patients. Of note, until postoperative day (POD) 2, P/FR did not differ among both groups. Thereafter, the rate of patients with respiratory impairment was higher after OE on POD 3, 5, and 10 (p ≤ 0.05) and tended being higher on POD 7 and 9 (p ≤ 0.1). Although the duration of LAE procedure was slightly longer (total: p = 0.07, thoracic part: p = 0.004), the duration of surgery (Spearman’s rank correlation coefficient (rsp) = −0.267, p = 0.006), especially of laparotomy (rsp = −0.242, p = 0.01) correlated inversely with respiratory impairment on POD 3 after OE. Pneumonia occurred on POD 5 (1–25) and 8.5 (3–14) after OE and LAE, respectively, with the highest incidence after OE (p = 0.01). In conclusion, respiratory impairment and pulmonary complications occur frequently after esophagectomy. Although early respiratory impairment is independent of the surgical approach, postoperative pneumonia rate is reduced after LAE.
Measurement of Wideband Absorbance as a Test for Otosclerosis
Authors: Śliwa Lech , Kochanek Krzysztof , Jedrzejczak W. Wiktor , Mrugała Kacper , Skarżyński Henryk
Published: June 2020

The purpose of this study was to investigate the effectiveness of wideband energy absorbance in diagnosing otosclerosis by comparing the differences in acoustic absorbance between otosclerotic and normal ears. Exactly 90 surgically confirmed otosclerotic ears were included in the test group. The control group consisted of 126 matched normal-hearing subjects. The Titan hearing test platform (Interacoustics) was used for absorbance and acoustic immittance tests. Energy absorbance, measured at tympanometric peak pressure, was analyzed in the range 226–8000 Hz. Differences between normal and otosclerotic ears were analyzed in quarter-octave bands. Wideband absorbance, i.e., absorbance averaged over the 226–2000 Hz band, and resonance frequency were calculated and compared between normal and otosclerotic ears. Significant differences between the absorbance of normal and otosclerotic ears were found, especially at low and middle frequencies. No significant effect of ear side or gender was observed. For average wideband absorbance and resonance frequency, less pronounced (although significant) differences were found between normal and otosclerotic ears. Measurement of peak-pressure energy absorbance, averaged over a frequency band around 650 Hz, provides a valid criterion in testing for otosclerosis. The test is highly effective, with a sensitivity and specificity of over 85% and area under receiver operating characteristic curve above 0.9. Average wideband absorbance can also be used, but its effectiveness is lower. Other immittance-related measures are considerably less effective.
Asynchronous Semantic Background Subtraction
Authors: Cioppa Anthony , Braham Marc , Van Droogenbroeck Marc
Published: June 2020

The method of Semantic Background Subtraction (SBS), which combines semantic segmentation and background subtraction, has recently emerged for the task of segmenting moving objects in video sequences. While SBS has been shown to improve background subtraction, a major difficulty is that it combines two streams generated at different frame rates. This results in SBS operating at the slowest frame rate of the two streams, usually being the one of the semantic segmentation algorithm. We present a method, referred to as “Asynchronous Semantic Background Subtraction” (ASBS), able to combine a semantic segmentation algorithm with any background subtraction algorithm asynchronously. It achieves performances close to that of SBS while operating at the fastest possible frame rate, being the one of the background subtraction algorithm. Our method consists in analyzing the temporal evolution of pixel features to possibly replicate the decisions previously enforced by semantics when no semantic information is computed. We showcase ASBS with several background subtraction algorithms and also add a feedback mechanism that feeds the background model of the background subtraction algorithm to upgrade its updating strategy and, consequently, enhance the decision. Experiments show that we systematically improve the performance, even when the semantic stream has a much slower frame rate than the frame rate of the background subtraction algorithm. In addition, we establish that, with the help of ASBS, a real-time background subtraction algorithm, such as ViBe, stays real time and competes with some of the best non-real-time unsupervised background subtraction algorithms such as SuBSENSE.
Organic Spintronics: A Theoretical Investigation of a Graphene-Porphyrin Based Nanodevice
Authors: del Castillo Elisabetta , Cargnoni Fausto , Soave Raffaella , Trioni Mario
Published: June 2020

Spintronics is one of the most exciting applications of graphene-based devices. In this work Density Functional Theory is used to study a nanojunction consisting of two semi-infinite graphene electrodes contacted with an iron-porphyrin (FeP) molecule, which plays the role of spin filter for the incoming unpolarized electrons. The graphene-FeP contact closely resembles the recently synthesized porphyrin-decorated graphene [He et al., Nat. Chem. 2017, 9, 33–38]. The analysis of the spectral properties of the system shows a variation of the orbital occupancy with respect to the isolated FeP molecule and an hybridization with the delocalized states of the substrate, while the overall magnetic moment remains unchanged. Doping the electrodes with boron or nitrogen atoms induces a relevant rearrangement in the electronic structure of the junction. Upon B doping the current becomes significantly spin polarized, while N doping induces a marked Negative Differential Resistivity effect. We have also investigated the possible exploitation of the FeP junction as a gas sensor device. We demonstrate that the interaction of CO and O2 molecules with the Fe atom, while being strong enough to be stable at room temperature (2.0 eV and 1.1 eV, respectively), induces only minor effects on the electronic properties of the junction. Interestingly, a quenching of the spin polarization of the current is observed in the B-doped system.
Modeling an Uncertain Productivity Learning Process Using an Interval Fuzzy Methodology
Authors: Chiu Min-Chi , Chen Tin-Chih Toly , Hsu Keng-Wei
Published: June 2020

Existing methods for forecasting the productivity of a factory are subject to a major drawback—the lower and upper bounds of productivity are usually determined by a few extreme cases, which unacceptably widens the productivity range. To address this drawback, an interval fuzzy number (IFN)-based mixed binary quadratic programming (MBQP)–ordered weighted average (OWA) approach is proposed in this study for modeling an uncertain productivity learning process. In the proposed methodology, the productivity range is divided into the inner and outer sections, which correspond to the lower and upper membership functions of an IFN-based fuzzy productivity forecast, respectively. In this manner, all actual values are included in the outer section, whereas most of the values are included within the inner section to fulfill different managerial purposes. According to the percentages of outlier cases, a suitable forecasting strategy can be selected. To derive the values of parameters in the IFN-based fuzzy productivity learning model, an MBQP model is proposed and optimized. Subsequently, according to the selected forecasting strategy, the OWA method is applied to defuzzify a fuzzy productivity forecast. The proposed methodology has been applied to the real case of a dynamic random access memory factory to evaluate its effectiveness. The experimental results indicate that the proposed methodology was superior to several existing methods, especially in terms of mean absolute error, mean absolute percentage error, and root mean square error in evaluating the forecasting accuracy. The forecasting precision achieved using the proposed methodology was also satisfactory.
Second-Order Dual Phase Lag Equation. Modeling of Melting and Resolidification of Thin Metal Film Subjected to a Laser Pulse
Authors: Majchrzak Ewa , Mochnacki Bohdan
Published: June 2020

The process of partial melting and resolidification of a thin metal film subjected to a high-power laser beam is considered. The mathematical model of the process is based on the second-order dual phase lag equation (DPLE). Until now, this equation has not been used for the modeling of phase changes associated with heating and cooling of thin metal films and the considerations regarding this issue are the most important part of the article. In the basic energy equation, the internal heat sources associated with the laser action and the evolution of phase change latent heat are taken into account. Thermal processes in the domain of pure metal (chromium) are analyzed and it is assumed that the evolution of latent heat occurs at a certain interval of temperature to which the solidification point was conventionally extended. This approach allows one to introduce the continuous function corresponding to the volumetric fraction of solid or liquid state at the neighborhood of the point considered, which significantly simplifies the phase changes modeling. At the stage of numerical computations, the authorial program based on the implicit scheme of the finite difference method (FDM) was used. In the final part of the paper, the examples of numerical computations (including the results of simulations for different laser intensities and different characteristic times of laser pulse) are presented and the conclusions are formulated.
Stability Analysis of Multi-Discrete Delay Milling with Helix Effects Using a General Order Full-Discretization Method Updated with a Generalized Integral Quadrature
Authors: Ozoegwu Chigbogu , Eberhard Peter
Published: June 2020

A tensor-based general order full-discretization method is enhanced with the capacity to handle multiple discrete delays and helix effects leading to a unique automated algorithm in the stability analysis of milling process chatter. The automated algorithm is then exploited in investigating the effects of interpolation order of chatter states and helix-induced terms on the convergence of milling stability lobes. The enhanced capacity to handle the distributed helix effects is based on a general order formulation of the Newton-Coates integral quadrature method. Application to benchmark milling models showed that high order methods are necessary for convergence of the low speed domain of stability lobes while all the numerically stable orders converge in the high speed domain where the ultra-high order methods are prone to numerical instability. Also, composite numerical integration of the helix-induced integrand beyond the usual zero-th order method leads to higher accuracy of stability lobes especially in the low speed domain.
Robust PD-Type Iterative Learning Control of Discrete Linear Repetitive Processes in the Finite Frequency Domain
Authors: Wang Lei , Li Mu , Yang Huizhong
Published: June 2020

This paper studies a robust iterative learning control design for discrete linear repetitive processes in the finite frequency domain. Firstly, the state-space model of the iterative learning process is deduced. Then the dynamic performance condition of the control system in the finite frequency domain is derived by combining it with the stability theory of discrete linear repetitive processes. The system performances in the finite frequency domain are then transformed into the corresponding solutions of the linear matrix inequality by using the generalised KYP lemma. Finally, an integrated state feedback PD-type iterative learning control strategy is proposed. The robust control problem with norm-bounded uncertainty and convex polyhedral uncertainty are also considered in this paper. The simulation of the injection velocity in injection molding verified that the proposed methods in this paper are more effective than the P-type state feedback iterative learning control algorithm.
Partial Characterization of Protease Inhibitors of Ulva ohnoi and Their Effect on Digestive Proteases of Marine Fish
Authors: Vizcaíno Antonio Jesús , Galafat Alba , Sáez María Isabel , Martínez Tomás Francisco , Alarcón Francisco Javier
Published: June 2020

This piece of research evaluates the presence of protease inhibitors in the macroalga Ulva ohnoi and provides an initial overview of their mode of action. The ability of Ulva protease inhibitors to inhibit digestive proteases of three marine fish species, as well as their capacity to hamper the hydrolysis of a reference protein by those fish proteases, were assessed. In addition, thermal stability and the mode of inhibition on trypsin and chymotrypsin were also studied. Dose-response inhibition curves and in vitro protein hydrolysis assays revealed a noticeable inhibition of fish enzymes when Ulva concentration increased in the assay. The thermal treatment of Ulva reduced markedly the inhibitory effect on fish digestive protease. Finally, Lineweaver–Burk plots indicated that trypsin and chymotrypsin inhibition consisted of a mixed-type inhibition mechanism in which the inhibitory effect depends on Ulva concentration. Overall, the results confirmed the presence of protease inhibitors in Ulva, though heat treatment was enough for inactivating these compounds.
A Mechanism for Inducing Compressive Residual Stresses on a Surface by Laser Peening without Coating
Authors: Sano Yuji , Akita Koichi , Sano Tomokazu
Published: June 2020

Laser peening without coating (LPwC) involves irradiating materials covered with water with intense laser pulses to induce compressive residual stress (RS) on a surface. This results in favorable effects, such as fatigue enhancement; however, the mechanism underlying formation of the compressive RS is not fully understood. In general, tensile RS is imparted on the surface of the material due to shrinkage after heating by laser irradiation. In this study, we assessed the thermo-mechanical effect of single laser pulse irradiation and introduce a phenomenological model to predict the outcome of LPwC. To validate this model, RS distribution across the laser-irradiated spot was analyzed using X-ray diffraction with synchrotron radiation. In addition, the RS was evaluated across a line and over an area, following irradiation by multiple laser pulses with partial overlapping. Large tensile RSs were found in the spot irradiated by the single pulse; however, compressive RSs appeared around the spot. In addition, the surface RS state shifted to the compressive side due to an increase in overlap between neighboring laser pulses on the line and over the area of irradiation. The compressive RSs around a subsequent laser spot effectively compensated the tensile component on the previous spot by controlling the overlap, which may result in compressive RSs on the surface after LPwC.
Effect of Dynamic Recrystallization on the Transformed Ferrite Microstructures in HSLA Steel
Authors: Li Ning , Kingkam Wilasinee , Han Renheng , Tang Ming , Zhang Hexin , Zhao Chengzhi
Published: June 2020

The flow stress behavior of high-strength low-alloy (HSLA) steel at different true strains was studied using a hot compression test. The effect of dynamic recrystallization (DRX) on the transformed ferrite microstructures was investigated with electron backscatter diffraction (EBSD). The EBSD analysis indicated that the fraction of high-angle grain boundaries (HAGBs) and DRX increased with increasing true strain. The low-angle grain boundaries (LAGBs) were gradually transformed into HAGBs with increasing DRX degree. When the true strain was increased to 0.916, the fraction of HAGBs increased to 85% and the fraction of DRX increased to 80.3%. The relatively high fraction of HAGBs was related to the complete DRX. The dislocations and substructures in the tested steel at different true strains were characterized by transmission electron microscopy (TEM). TEM observation shows that the nucleation of the dynamically recrystallized grains occurred by the bulging of the original grain boundaries. The DRX nucleation mechanism of the HSLA steel is the strain-induced grain boundary migration mechanism.
Microstructure of In-Situ Friction Stir Processed Al-Cu Transition Zone
Authors: Zykova Anna , Chumaevskii Andrey , Gusarova Anastasia , Kalashnikova Tatiana , Fortuna Sergei , Savchenko Nickolai , Kolubaev Evgeny , Tarasov Sergei
Published: June 2020

The majority of literature sources dedicated to dissimilar Al-Cu friction stir welding testifies to the formation of intermetallic compounds (IMC) according to diffusion-controlled reactions, i.e., without liquation on the Al/Cu interfaces. Fewer sources report on revealing Al-Cu eutectics, i.e., that IMCs are formed with the presence of the liquid phase. This work is an attempt to fill the gap in the results and find out the reasons behind such a difference. Structural-phase characteristics of an in-situ friction stir processed (FSP) Al-Cu zone were studied. The single-pass FSPed stir zone (SZ) was characterized by the presence of IMCs such as Al2Cu, Al2Cu3, AlCu3, Al2MgCu, whose distribution in the SZ was extremely inhomogeneous. The advancing side SZ contained large IMC particles as well as Al(Mg,Cu) solid solution (SS) dendrites and Al-Al2Cu eutectics. The retreating side SZ was composed of Al-Cu solid solution layered structures and smaller IMCs. Such a difference may be explained by different levels of heat input with respect to the SZ sides as well as by using lap FSP instead of the butt one.
The Cardiac Lipidome in Models of Cardiovascular Disease
Authors: Tomczyk Mateusz M. , Dolinsky Vernon W.
Published: June 2020

Cardiovascular disease (CVD) is the leading cause of death worldwide. There are numerous factors involved in the development of CVD. Among these, lipids have an important role in maintaining the myocardial cell structure as well as cardiac function. Fatty acids (FA) are utilized for energy, but also contribute to the pathogenesis of CVD and heart failure. Advances in mass spectrometry methods have enabled the comprehensive analysis of a plethora of lipid species from a single sample comprised of a heterogeneous population of lipid molecules. Determining cardiac lipid alterations in different models of CVD identifies novel biomarkers as well as reveals molecular mechanisms that underlie disease development and progression. This information could inform the development of novel therapeutics in the treatment of CVD. Herein, we provide a review of recent studies of cardiac lipid profiles in myocardial infarction, obesity, and diabetic and dilated cardiomyopathy models of CVD by methods of mass spectrometry analysis.
Wireless E-Nose Sensors to Detect Volatile Organic Gases through Multivariate Analysis
Authors: Rahman Saifur , Alwadie Abdullah S. , Irfan Muhammed , Nawaz Rabia , Raza Mohsin , Javed Ehtasham , Awais Muhammad
Published: June 2020

Gas sensors are critical components when adhering to health safety and environmental policies in various manufacturing industries, such as the petroleum and oil industry; scent and makeup production; food and beverage manufacturing; chemical engineering; pollution monitoring. In recent times, gas sensors have been introduced to medical diagnostics, bioprocesses, and plant disease diagnosis processes. There could be an adverse impact on human health due to the mixture of various gases (e.g., acetone (A), ethanol (E), propane (P)) that vent out from industrial areas. Therefore, it is important to accurately detect and differentiate such gases. Towards this goal, this paper presents a novel electronic nose (e-nose) detection method to classify various explosive gases. To detect explosive gases, metal oxide semiconductor (MOS) sensors are used as reliable tools to detect such volatile gases. The data received from MOS sensors are processed through a multivariate analysis technique to classify different categories of gases. Multivariate analysis was done using three variants—differential, relative, and fractional analyses—in principal components analysis (PCA). The MOS sensors also have three different designs: loading design, notch design, and Bi design. The proposed MOS sensor-based e-nose accurately detects and classifies three different gases, which indicates the reliability and practicality of the developed system. The developed system enables discrimination of these gases from the mixture. Based on the results from the proposed system, authorities can take preventive measures to deal with these gases to avoid their potential adverse impacts on employee health.
Mobility Models Based on Forward Current-Voltage Characteristics of P-type Pseudo-Vertical Diamond Schottky Barrier Diodes
Authors: Ha Min-Woo , Seok Ogyun , Lee Hojun , Lee Hyun Ho
Published: June 2020

Compared with silicon and silicon carbide, diamond has superior material parameters and is therefore suitable for power switching devices. Numerical simulation is important for predicting the electric characteristics of diamond devices before fabrication. Here, we present numerical simulations of p-type diamond pseudo-vertical Schottky barrier diodes using various mobility models. The constant mobility model, based on the parameter μconst, fixed the hole mobility absolutely. The analytic mobility model resulted in temperature- and doping concentration-dependent mobility. An improved model, the Lombard concentration, voltage, and temperature (CVT) mobility model, considered electric field-dependent mobility in addition to temperature and doping concentration. The forward voltage drop at 100 A/cm2 using the analytic and Lombard CVT mobility models was 2.86 and 5.17 V at 300 K, respectively. Finally, we used an empirical mobility model based on experimental results from the literature. We also compared the forward voltage drop and breakdown voltage of the devices, according to variations in p- drift layer thickness and cathode length. The device successfully achieved a low specific on-resistance of 6.8 mΩ∙cm2, a high breakdown voltage of 1190 V, and a high figure-of-merit of 210 MW/cm2.
Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives
Authors: Shinde Tanvi , Hansbro Philip M , Sohal Sukhwinder Singh , Dingle Peter , Eri Rajaraman , Stanley Roger
Published: June 2020

Viral respiratory infections (VRIs) can spread quickly and cause enormous morbidity and mortality worldwide. These events pose serious threats to public health due to time lags in developing vaccines to activate the acquired immune system. The high variability of people’s symptomatic responses to viral infections, as illustrated in the current COVID-19 pandemic, indicates the potential to moderate the severity of morbidity from VRIs. Growing evidence supports roles for probiotic bacteria (PB) and prebiotic dietary fiber (DF) and other plant nutritional bioactives in modulating immune functions. While human studies help to understand the epidemiology and immunopathology of VRIs, the chaotic nature of viral transmissions makes it difficult to undertake mechanistic study where the pre-conditioning of the metabolic and immune system could be beneficial. However, recent experimental studies have significantly enhanced our understanding of how PB and DF, along with plant bioactives, can significantly modulate innate and acquired immunity responses to VRIs. Synbiotic combinations of PB and DF potentiate increased benefits primarily through augmenting the production of short-chain fatty acids (SCFAs) such as butyrate. These and specific plant polyphenolics help to regulate immune responses to both restrain VRIs and temper the neutrophil response that can lead to acute respiratory distress syndrome (ARDS). This review highlights the current understanding of the potential impact of targeted nutritional strategies in setting a balanced immune tone for viral clearance and reinforcing homeostasis. This knowledge may guide the development of public health tactics and the application of functional foods with PB and DF components as a nutritional approach to support countering VRI morbidity.
The Secret ‘After Life’ of Foraminifera: Big Things Out of Small
Authors: Buckman Jim , Mahoney Carol , März Christian , Wagner Thomas
Published: June 2020

Calcareous and siliceous microorganisms are common components of mudrocks, and can be important in terms of stratigraphy and environmental interpretation. In addition, such microorganisms can have a significant ‘after life’, through post-mortem alteration, and represent a potential source of additional information about the diagenetic and deformation history of the rock unit. Some examples of the latter are illustrated in this study from foraminifera within a Cretaceous black shale of Colombia. This includes foraminifera tests acting as understudied repositories of authigenic calcite cement, and of elements such as Ba, Zn, Fe and S through the formation of baryte, sphalerite and iron sulphides (pyrite, marcasite). Such repositories, within the body chambers of foraminiferal tests, can provide important windows into the diagenetic processes within mudstones. If calcite cement is not recognised or separated from biogenic calcite, the depositional calcite budget can be easily overestimated, skewing the application of mudrock classification schemes, and affecting environmental interpretation including that of productivity. The elements Ba, Zn and Fe (often in ratio with Al) are commonly utilised as geochemical proxies of environmental parameters (productivity, bottom water redox conditions, etc.). Therefore, the presence of significant amounts of baryte, sphalerite and pyrite-marcasite (within foraminifera) should be noted and their origins (source and timing) investigated based on their spatial relationships before making environmental deductions based on geochemical analysis alone. Additionally, commonly observed marginal shell damage of many of the observed foraminifera is reported. We interpret this damage, for the first time, as an indicator of lateral dissolution, brought about by horizontal foreshortening during orogenesis. This is also supported by the occurrence of microscale anastomosing horizontal to inclined baryte-filled fractures within the mudstone matrix.