bluuebunny/crossref_metadata_2025 huggingface dataset:
Usutu virus in the Iberian peninsula: A systematic review
Authors: Loureiro Filipa , Cardoso Luís , Mesquita João , Matos Ana , Matos Manuela , Coelho Ana
Published: January 2025

Studies on Usutu virus (USUV) in Europe have been increasing through time,
with USUV infection being identified in humans and animals. The emergence of
USUV in Europe draws our attention to how an arbovirus is able to spread,
adapt, and evolve in a unconventional environment. Understanding the
epidemiological and evolutionary processes that contribute to the
appearance, maintenance, and further spread of viral diseases is the key to
develop and implement surveillance strategies to control them. The aim of
the present systematic review was to compile and evaluate all the published
data on USUV from studies performed in humans, animals, and environmental
samples in the Iberian Peninsula. The electronic databases Mendeley,
PubMed, Scopus, and Web of Science were thoroughly searched, and research
published up until July 6th 2024 were included. After full reading and
application of PRISMA exclusion/inclusion criteria, a total of 20 eligible
papers were considered. Overall, the present review shows that USUV is
circulating in humans, animals and in the environment in the Iberian
Peninsula.
Treatment outcomes and short-term stability in adult anterior openbite patients treated with or without extractions: a National Dental Practice-Based Research Network study
Authors: Greenlee Geoffrey M. , Collins Jessica L. , Leroux Brian , Allareddy Veerasathpurush , Jolley Cameron , Shin Kyungsup , Vermette Michael ,   The National Dental PBRN Collaborative Group, Huang Greg J.
Published: January 2025

Objectives

To investigate whether extractions in adult anterior openbite (AOB) patients lead to improved treatment outcomes and better short-term stability.

Materials and Methods

Records of extraction (EXT) and nonextraction (NE) adult patients were identified from all patients treated with fixed appliances through the National Dental Practice-Based Research Network. Photographic Openbite Severity Index was used to assess treatment success and stability. Skeletal, dental, and soft tissue treatment outcomes were evaluated using cephalometric analysis.

Results

Pretreatment and posttreatment records were collected for 115 patients. Thirty-three were treated with extractions; 82 were treated without extractions. The EXT group was younger, more crowded, and had less previous orthodontic treatment. Success rate of AOB correction in the EXT group was slightly higher (97%) than the NE group (92%) but not statistically different. No significant differences were observed in skeletal outcomes. The EXT group exhibited more lingual tipping and posterior movement of maxillary and mandibular incisors and less extrusion of mandibular incisors. Dental changes in the EXT group were associated with increased nasolabial angle and lip retraction. The small number of patients with AOB relapse did not provide enough power to identify differences in stability between the two groups.

Conclusions

Orthodontists have high success correcting AOB with or without extractions. The EXT group displayed more retraction and lingual tipping of incisors as well as increased retraction of soft tissues. Stability of AOB closure was more than 90% for both groups after 1 year, with marginal increases in stability after extractions.
Status of Continuous Glucose Monitoring Technology in Clinical Practice
Authors: O’Connor Clare , Aleppo Grazia
Published: January 2025

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Apps for Diabetes Management and Communication between Patients and Providers
Authors: Ahn David
Published: January 2025

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Interpretation of Meters, Pumps, and Continuous Glucose Monitoring Downloads
Authors: Weaver Kathryn , Hirsch Irl B.
Published: January 2025

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Continuous Glucose Monitoring and Insulin Pumps in the Management of Diabetes in Pregnancy
Authors: Yamamoto Jennifer M. , Murphy Helen R.
Published: January 2025

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Helping Patients Understand Predictive Technology with the Use of Professional Continuous Glucose Monitoring
Authors: Hughes Lucille , Madtes Sara
Published: January 2025

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Resilience: How Technology Has Helped Me Flourish with Type 1 Diabetes
Authors: Stephens Elizabeth
Published: January 2025

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Safe Removal of Polypoid Epithelial Neoplasms of Colonic Mucosa Using Method of Preliminary Preventive Ligation
Authors:   Ryazan State Medical University, Natal’skiy Aleksandr A. , Filimonov Viktor B. ,   Ryazan State Medical University, Shadskiy Stanislav O. ,   Mytishchi Regional Clinical Hospital, Pashkin Korneli P. ,   Lukhovitsy Hospital
Published: January 2025

INTRODUCTION: Currently, endoscopic mucosal resection is a ‘gold standard’ in the treatment of epithelial neoplasms of the colonic mucosa. When removing large polypoid neoplasms, the operating surgeon is faced with the problem of a high risk of bleeding from the supplying peduncle of polyp that may occur both intraoperatively and in the immediate postoperative period.
This article considers a method for preventing bleeding when removing polypoid colorectal neoplasms by application of ligature on the polyp peduncle using a newly developed ligation device.
CONCLUSION: The use of a new ligation device provides effective mechanical preventive hemostasis in endoscopic interventions.
Clinical and Neurophysiological Characteristics of Patients with Compressive Radiculopathies
Authors:   Ryazan Medical State University, Barinova Irina A. ,   City Clinical Hospital of Emergency Medical Care, Zorin Roman A. ,   Ryazan Medical State University, Kharlamov Igor’ V. ,   City Clinical Hospital of Emergency Medical Care, Zhadnov Vladimir A. ,   Ryazan Medical State University
Published: January 2025

INTRODUCTION: Clinical manifestations of compressive vertebrogenic radiculopathies include pain disorders. This necessitates complex parameterization of individual components of pain syndrome and identification of the respective clinical and functional correlations.
AIM: Comprehensive clinical and neurophysiological characteristics of patients with different effectiveness of conservative treatment of L5 and S1vertebrogenic radiculopathy.
MATERIALS AND METHODS: The open prospective study included 61 patients. Based on the dynamics of pain syndrome on the visual-analog pain scale (VAS) at 3 weeks and 3 months, using cluster analysis, the patients were divided into groups with insignificant pain dynamics with conservative treatment (group 1 — 32 patients) and with significant pain regression (group 2 — 29 patients). In the patients, endogenous evoked potential of the contingent negative variation (CNV), somatosensory evoked potentials, late electroneuromyographic responses were recorded, and heart rate variability (HRV) was studied.
RESULTS: In group 1, a higher CNV amplitude, higher HRV oscillation amplitude in the HF spectrum, and a lower amplitude of F-response on the affected side were revealed. There were found direct correlations between the CNV amplitudes and VLF HRV and VAS on day 1 of the visit, and negative correlations between the amplitude of somatosensory evoked potentials (SSEP) and VAS at 3 months. In group 2, direct correlations were found between the SSEP amplitude, stress index, and F-response from the VAS level on day 1 of the visit, as well as a correlation between heart rate variability and VAS on month 3 after treatment. A logit regression analysis model was created that permitted a highly sensitive distribution of patients into a group with high treatment effectiveness; the independent factors in this model were the CNV amplitude and the normalized HF HRV index.
CONCLUSIONS: Correlates of the intensity of pain syndrome in the acute period are the severity of suprasegmental and sympathetic autonomic influences, the power of specific somatosensory afferentation, a high level of readiness for a motor response; upon that, predictor of alleviation of pain syndrome is an initially high level of specific somatosensory afferentation.
Public-Private Partnership in Healthcare in the Russian Federation: a Story of Success or a Story of Failure?
Authors:   Russian Research Institute of Health, Smyshlyayev Aleksey V.
Published: January 2025

INTRODUCTION: The need to use tools of public-private partnership (PPP) in the implementation of investment projects is reflected in the national programs and development strategies. Currently, a request has been formed by the state for the implementation of PPP projects in the healthcare sector. Upon that, PPP does not show convincing development dynamics in the sector.
AIM: To analyze problems of PPP development in the healthcare sector at the current stage of development in the RF.
MATERIALS AND METHODS: Results of qualitative interviews and expert assessments. In the work, qualitative (expert interviews) and quantitative research methods (assessment of expert agreement) were used.
RESULTS: According to experts, the key factors limiting development of PPP in the healthcare sector are: a high degree of influence of political leadership on decision making; priority of the state, rather than PPP, order; low estimated profitability of most projects; high bureaucratization of processes; insufficient experience in implementation of projects; low level of competence of officials; high risk of changes in the legal and regulatory framework; integration of projects in the compulsory health insurance system. According to experts, the key drivers of PPP development in the healthcare sector are: extensive and developed legal and regulatory framework; availability of centers for PPP development; a large number of investors; practice of application of PPP tools in different healthcare sectors; existence of negotiation platforms for discussing pressing issues between the state and business.
CONCLUSION: The presence of significant limiting factors for the development of PPP in the healthcare sector is an obstacle to an increase in the attractiveness of this sector for investors. The existence of development drivers indicates a generally positive trend in the development of PPP in the healthcare sector. At the same time, ideologization of the sector is necessary with establishing an ‘order’ for the implementation of projects in the sector using PPP tools. Digitalization of processes, a project monitoring system and a more flexible integration of the compulsory health insurance system into the PPP field will increase the investment attractiveness of the state healthcare system.
Anterior Abdominal Wall Endometriosis. Surgical Treatment of a Complicated Clinical Case
Authors:   Stavropol State Medical University, Grigor’yants Armen A. , Aksenenko Viktor A. ,   Stavropol State Medical University, Aksenenko Denis V. ,   Stavropol State Medical University
Published: January 2025

INTRODUCTION: Endometriosis of the anterior abdominal wall (EAW) is a rare pathology, so all cases of monitoring the results of treatment are undoubtedly of interest to the surgical community. In most patients, during operations involving the opening of the uterine cavity, endometrial cells enter the edges of the surgical wound, which in some cases causes the development of EAW.
In the described clinical case, surgical treatment in the amount of removal of the endometrioid focus within healthy tissues served as a radical therapeutic intervention, and the appointment of fourth-generation progestogens in the postoperative period helped preventing relapse of the disease in the future. Thus, according to the assessment of clinical symptoms, regression of pain was noted, with its complete disappearance during the first months after surgery. According to the ultrasound examination data, restoration of the anatomical integrity of the anterior abdominal wall was achieved without the formation of defects. Secondary foci of endometriosis were not detected.
CONCLUSION: The presented clinical case clearly demonstrated the mistakes made in the conservative treatment of a patient with EAW. This led to an aggravation of the severity of the disease, technical difficulties during the surgical intervention (including the impossibility of autoplasty), which required closure of the defect with a synthetic mesh implant.
Pathogenetic Mechanisms of Aseptic Loosening of Hip Endoprosthesis Components after Total Arthroplasty
Authors:   Chita State Medical University, Denisov Aleksey I. , Eshidorzhiyev Damdin A. ,   Chita State Medical University, Gusev Kirill A. ,   Chita State Medical University, Dorzheyev Vladimir V. ,   Chita State Medical University, Miromanov Aleksandr M. ,   Chita State Medical University
Published: January 2025

INTRODUCTION: In the structure of complications after total hip arthroplasty, aseptic instability is one of the main reasons for revision interventions, which requires continued study of the causes, methods of early diagnosis and biological approaches to the treatment of osteolysis and aseptic loosening.
AIM: To consider modern pathogenetic aspects of aseptic loosening of hip endoprosthesis components after total arthroplasty.
MATERIALS AND METHODS: The search for literature sources was conducted in open databases of scientific literature PubMed and eLibrary. The search depth for the main keywords (aseptic implant loosening, endoprosthetics, pathogenesis) was 20 years. The criterion for inclusion of sources in the analytic study was the presence of a full or structured text of the article (indicating specific quantitative data). The exclusion criteria were works that have not been published (dissertation studies and author’s abstracts), clinical cases, abstracts of reports, as well as educational and methodological materials.
RESULTS: In the review, the analysis of the literature data is presented on the state of issues of studying molecular-genetic aspects of the mechanisms of bone resorption, periprosthetic osteolysis, impaired osteointegration after total endoprosthetics, including those that lead to the development of aseptic loosening of hip endoprosthesis components. The mechanisms of the most important, in our opinion, pathogenetic factors that may lead to aseptic loosening, are considered.
CONCLUSION: The osteolysis formation processes leading to loosening of endoprosthesis components, are multifaceted both in terms of the triggering mechanisms and of the development of immune response. Osteolysis is the result of disruption of local tissue homeostatic mechanisms both at the level of sensors, regulators and of effectors. The study and precise identification of deregulated signaling pathways, mediators and cell differentiation programs contributing to periprosthetic osteolysis, will help in the development of diagnostic, selective and targeted therapeutic strategies.
Relationship between Lung Diseases and Diabetes Mellitus
Authors:   Ryazan State Medical University, Uryas’yev Oleg M. , Tverdova Lyudmila V. ,   Ryazan State Medical University, Pristupa Mariya A. ,   Ryazan State Medical University
Published: January 2025

INTRODUCTION: The prevalence of diabetes mellitus (DM) and its high comorbidity makes one think that that much is still unknown about the complex pathogenesis of this chronic disease and its impact on an organism. Besides damaging already studied target organs, such as retina, kidneys, nervous and cardiovascular system, DM can also affect lungs. Pulmonary dysfunction in DM began to interest scientists and practitioners several decades ago, since patients with chronic hyperglycemia often complain of respiratory symptoms and have an increased risk of developing lung diseases. However, for some time, this relationship was forgotten. Currently, this topic has again regained relevance: the role of chronic uncontrolled hyperglycemia, insulin resistance, endogenous contrainsular hormones, metaflammation, and impairment of humoral and innate immunity is discussed in the development of pulmonary dysfunction. There is increase in the number of patients with undiagnosed DM, which imperceptibly leads to damages of the target organs including pulmonary dysfunction. Some pulmonary diseases have common pathogenetic mechanisms with DM, which is of much interest for research. An important task is to understand what pathological process is primary: pulmonary dysfunction or DM. In this review, the relationship between DM, restrictive and obstructive disorders of lung ventilation is considered. Comorbid lung diseases running with restrictive disorders are considered on an example of idiopathic pulmonary fibrosis. An example of a disease with an obstructive component is chronic obstructive pulmonary disease.
CONCLUSION: This review permits to make preliminary conclusions about DM being equally associated with both restrictive and obstructive disorders in lung ventilation. Diabetic microangiopathy damages the lung system resulting in pneumopathy. This leads to the idea of a more thorough control of the respiratory function in diabetic patients. Lungs possessing extensive microcirculatory network and large reserve, remain protected against damaging effect of hyperglycemia for a relatively long time compared to other organs. Screening and awareness of interstitial lung diseases associated with diabetes, will significantly reduce lung comorbidity in patients with DM.
Long-Term Results of Kidney Resection Using a Prolene Mesh Implant
Authors:   Tula Regional Clinical Oncological Dispensary, Petryayev Aleksandr V. , Filimonov Viktor B. ,   N. A. Lopatkin Research Institute of Urology and Interventional Radiology,   Ryazan State Medical University,   Peoples' Friendship University of Russia named after Patrice Lumumba, Sobennikov Ivan S. ,   Ryazan State Medical University, Filimonov Aleksandr V. ,   I. M. Sechenov First Moscow State University (Sechenovskiy University)
Published: January 2025

INTRODUCTION: Renal neoplasms are among the most common diseases in urological practice. The detection rate of new cases of kidney cancer continues to grow, with the annual increment of primary cases of kidney cancer of 2%.
AIM: To evaluate the long-term five-year results of the surgery of kidney resection using a prolene mesh implant, developed and introduced in the clinical practice.
MATERIALS AND METHODS: The study included 90 patients who underwent kidney resection surgery more than 5 years before. Forty-five patients were operated on using the classic method (group 1), 45 patients were operated on according to the method of kidney resection using a prolene mesh developed in the clinic (group 2). The following characteristics of the remote postoperative period were studied: overall five-year survival, cancer-specific five-year survival, glomerular filtration rate and azotemia levels before the surgery, at 1.5 months and 5 years after the surgery.
RESULTS: The studied groups of patients were comparable in the initial characteristics. The overall and cancer-specific survival rates were comparable in groups 1 and 2 (р > 0.1). In the course of study, in group 1, at 1.5 months after the operation, the creatinine/urea parameter increased by 8.9/9.8%, in the long-term postoperative period by 19.4/15.5% (р < 0.05). In group 2 patients, the growth by 5.2/14.8% and 2.9/14.6%, respectively, was noted in the same periods (р < 0.05). When using the method of kidney resection with application of mesh implant, less pronounced changes in the glomerular filtration rate were noted as compared to the initial data (р = 0.0001).
CONCLUSION: The developed method of kidney resection with use of a prolene mesh is characterized by better functional results in the remote postoperative period compared to the classic method, which is manifested by less pronounced changes in the level of glomerular filtration rate and fewer long-term non-oncological complications.
Clinical and Functional Correlates of Manifestations of Epileptic Seizures in Children with Benign Epileptiform Patterns on Electroencephalogram
Authors:   Ryazan Medical State University, Kalinina Yuliya Yu. ,   Medical and Pedagogical Center «Neuroclinic», Zorin Roman A. ,   Ryazan Medical State University, Afontsova Anna A. ,   Medical and Pedagogical Center «Neuroclinic», Zhadnov Vladimir A. ,   Ryazan Medical State University, Leonov Gennadiy A. ,   Ryazan Medical State University
Published: January 2025

INTRODUCTION: The phenomena of age-dependent epileptiform patterns on the electroencephalogram (benign epileptiform discharges of childhood, BEDCs) are associated with a wide range of disorders: from the peculiarities of neuropsychological development of a child, self-limited age-dependent epilepsies to severe epileptic encephalopathies.
AIM. To identify a complex of electroencephalographic and clinical correlates associated with epileptic seizures in patients with BEDCs.
MATERIALS AND METHODS: A retrospective analysis of 62 patients with BEDCs on the electroencephalogram (EEG) was conducted, including 40 boys and 22 girls (mean age 6.7 years). In 30 patients, epileptic seizures were absent (group 1), in 32 patients they were verified within certain epileptic syndromes (group 2). The subjects underwent video-electroencephalographic monitoring, magnetic resonance imaging of the brain. To analyze the relationship of the identified parameters with the presence of epileptic seizures, classifications algorithms were created based on the artificial neural network technologies.
RESULTS: Groups of patients with and without epileptic seizures did not differ in age and gender. In the group with epileptic seizures patients with age-dependent genetic focal epilepsy predominated, a reliably higher index of BEDCs (p = 0.001), predominance of the frontal-central localization of BEDCs (p = 0.031) and diffuse spread of BEDCs (p = 0.048) were identified. No reliable differences were found between the groups in the congenital somatic disorders of other spheres and in the character of neuropsychological disorders. The created models based on artificial neural networks (multilayer perceptron with 9 input neurons, 4 intermediate layer neurons and 2 output neurons) demonstrated good sensitivity (85%) and specificity (88%) in classifying patients into group 2.
CONCLUSION: A complex of both neurophysiological and clinical-psychological characteristics of patients with BEDCs on EEG is associated with the presence of epileptic seizures within certain epileptic syndromes. Correlates of the presence of epileptic seizures in this category of patients are diffuse spread of BEDCs, their localization and index.
Organ Preservation Minimally Invasive Treatment of Deforming Osteoarthritis of the Knee Joint in a Multimorbid Patient
Authors:   Russian University of Medicine, Medzhidov Kamal M. ,   Domodedovo Hospital, Parshikov Mikhail V. ,   Russian University of Medicine, Gur’yev Vladimir V. ,   Russian University of Medicine, Shermatov Kymbatbek R. ,   Domodedovo Hospital, Shakhshayev Marat K. ,   Clinical Hospital No. 85
Published: January 2025

INTRODUCTION: Deforming osteoarthritis of the knee joint is a widespread disease in the world with pain as the main symptom appearing at later stages of the lesion. The disease leads to deformation of the joint and disability of the patient, with pain syndrome acquiring a chronic character. Today, there are many conservative complexes for prevention and treatment of the disease, but their application does not reduce the number of newly recorded cases and does not lead to a stable remission of pain syndrome. If conservative treatment appears ineffective, especially at later stages of the disease, surgical treatment methods are used. The majority of surgeries are invasive, and patients with severe chronic diseases often have contraindications for large-scale interventions, and some of them are not psychologically prepared for them. At present, with the development of technologies of treatment for osteoarthritis, considerable attention is paid to minimally invasive and organ preserving techniques of surgical treatment; in this context the search for alternative methods is relevant.
The article describes successful application of endovascular embolization of the popliteal artery branches in a 64-year-old female patient with stage 3 osteoarthritis of the knee joint and concomitant multimorbid pathology.
CONCLUSION: Endovascular embolization of the popliteal artery branches is a promising method for multimorbid patients with osteoarthritis not only at early, but also at late stages of the disease, as a method permitting to delay endoprosthetics. However, before this technique has been more widely implemented in practice, it is necessary to solve such issues as: developing clear indications and contraindications for its use, demonstrating the evidentiary potential of the method, determining the genesis of the observed complications and taking measures to prevent them.
Surgical Treatment of a Female Patient with Bouveret’s Syndrome
Authors:   Ryazan State Medical University, Tarasenko Sergey V. ,   City Clinical Hospital of Emergency Medical Care, Romashov Dmitriy V. ,   City Clinical Hospital of Emergency Medical Care, Panin Il’ya V. ,   Ryazan State Medical University,   City Clinical Hospital of Emergency Medical Care, Zhuchkova Ul’yana V. ,   Ryazan State Medical University,   City Clinical Hospital of Emergency Medical Care, Glotov Dmitriy A. ,   Ryazan State Medical University,   City Clinical Hospital of Emergency Medical Care, Kulakova Dar’ya V. ,   City Clinical Hospital of Emergency Medical Care
Published: January 2025

INTRODUCTION: Gallstone disease (GSD) is a common and socially significant problem of modern society. Despite the fact that the disease has been sufficiently studied, there are still many controversial issues in diagnostics and choosing the correct treatment tactics. One of the rare complications of gallstone disease is Bouveret's Syndrome.
The article presents a clinical case of surgical treatment of a 59-year-old patient with this syndrome. Early diagnostics of this complication was difficult for a number of reasons such as: the inability to perform computed tomography (CT) in the first days of the disease; difficulty in examining the duodenal bulb due to its deformation, as well as the patient's restless behavior and abundant vomiting during video gastroduodenoscopy (VGDS); simultaneous development of two complications: acute pancreatitis and intestinal obstruction. The surgery of choice in this case was enterotomy with gallstone extraction to eliminate high-level intestinal obstruction. During a follow-up ultrasound examination performed at an outpatient clinic, a concrement was found in the neck of the gallbladder. Due to the possible recurrence of the calculus migration into the small intestine and subsequent development of obstruction, after diagnostic video laparoscopy, it was decided to perform lithoextraction.
CONCLUSION: Gallstone intestinal obstruction is a rare complication of cholecystolithiasis. The difficulty in diagnosing Bouveret's Syndrome is due to the atypical clinical picture, laboratory and instrumental data, which often leads to late surgical intervention. Cholecystolithiasis can be complicated by the migration of the calculus into the common bile duct and giving rise acute pancreatitis or acute cholecystitis. On the other hand, it can lead to development of a fistula and the occurrence of intestinal obstruction. CT-scanning is recommended and obviously advisable as the main diagnostic method, which allows for an early diagnosis of the disease and timely surgical treatment, which can be performed both open and either laparoscopically.
Protection Optimisation via Novel Simulation (PONS) – A Bridge to the Next Generation of Armour Development
Authors:   , Howells David
Published: January 2025

Primary blast lung injury is a contributor to lethality in both military and civilian life. Mitigation of such injuries is a topic which would benefit from deeper investigations of the mechanism(s) by which these injuries manifest. For this purpose, this study has developed 1D and 3D finite element models alongside physical models of the human thorax to be used in blast simulations and experimental testing respectively. The initial hypothesis was that injury was governed by the action of stress waves within a few milliseconds after loading begins. The threshold of injury scenario outlined in the literature was investigated with consideration for the differences in loading (long-duration and short-duration). A comparison of the 1D and 3D computational models indicated that 1D modelling was insufficient in capturing the requirements for accurately predicting blast injury. Several parameters were explored computationally as metrics for prediction of primary blast lung injury. The conclusion formed was that tensive stress presents the most consistent indicator of injury in both long-duration and short-duration blasts. A value of 8.7kPa was proposed as a threshold value for injury using this parameter. This is substantially lower than the external loads applied. Distributions of all stresses in the 3D computational models were indicative of realistic injury distribution, proven through comparison of the time varying position of stress contours with CT images of PBLI victims. A reduced-scale physical thorax model was constructed following a material characterisation study of PolyJet materials. Experimental blast loading of this model using a shock tube indicating that the external load was representative of the internal loads. Results were inconclusive due to excessive vibrations, however there are indications that reflections scattered by the mediastinum were detected. This first iteration of the model can undergo significant improvements and represents a promising platform for future investigations of primary blast lung injury.
Problems Faced by Tribes in Collection and Marketing of Tendu (Diospyros melanoxylon Roxb.) Fruit in Jhalawar District of Rajasthan
Authors: Sharma Shirish , Dadhich Sourabh
Published: January 2025

The present study was conducted during September to December, 2022 to focus on the problems in collection and marketing of tendu fruit by tribes in Jhalawar district of Rajasthan. This district was selected purposively because the more than 15% tribal population is residing in this district. In this study 3 blocks namely: Jhalrapatan, Aklera and Khanpur blocks were selected purposively. From each selected block 50 respondents were selected randomly thus making total sample size to 150. The result of the study show that the marketing pattern of respondents shows that the weekly market was respondents’ first choice. The majority of respondents, 86 (57.33%), were between the ages of 36 and 50, with only 44 (29.33%) between the ages of 18 and 30. Social involvement, occupation, and extent of sustainable livelihood were negative and significantly correlated at the 1% and 5% level of probability. Major source of income is non-farm activities, followed by agriculture related activities. Majority of respondents use bicycles as mode of transport, while motor bikes are used by only 26.00 % of respondents and majority of the collectors were literate. The major problem faced by respondents was lack of developed market infrastructure for Tendu fruit (94.66%) and least was lack of inexpensive storage facilities (24.66%). The majority respondents suggested that government develop the existing market infrastructure for marketing to deal with collection and marketing problem of Tendu fruit.
Indicadores del Desarrollo Humano Sostenible Diferenciado en los municipios que integran el Valle de Tulancingo
Authors: Calderón Hernández Arturo , Lozano Rosales Raymundo
Published: January 2025

Este trabajo tiene como objetivo identificar las diferencias existentes en los indicadores de desarrollo humano, pobreza y marginación, su interrelación dinámica y su probable relación con las capacidades funcionales municipales con que se opera el desarrollo sostenible y la igualdad de oportunidades en los municipios que integran la región del Valle de Tulancingo. El estudio se enfoca en presentar los indicadores que diferencian los avances logrados por cada municipio en los temas señalados. Para ello se han consultado referencias teóricas e informes del desarrollo sostenible de los municipios del estado de Hidalgo. Metodológicamente, se ubica dentro de una investigación mixta longitudinal de alcance exploratorio, utilizando una técnica de estudio causal comparativo y análisis documental. Los hallazgos identifican las brechas existentes entre las diferentes demarcaciones políticas consideradas y reconocen los efectos diferenciados. Finalmente se observa una interrelación entre el desarrollo humano, la pobreza y la marginación y se plantea una propuesta orientada a fortalecer las áreas de oportunidad detectadas en el Índice de Capacidades Funcionales Municipales.  
El Índice de Capacidades Funcionales Municipales, definido como una herramienta para medir la operatividad de los municipios en el desarrollo sostenible, juega un papel clave en la identificación de áreas de oportunidad.
10 anos do pontificado de Francisco
Authors: Xavier Donizete José , da Silva Dias Tiago Cosmo
Published: January 2025

Era o dia 13 de março de 2013 quando o cardeal argentino Jorge Mario Bergoglio apareceu na sacada da Basílica de São Pedro. Tudo nele falava, seja dele, pessoalmente, seja do seu próprio projeto para a Igreja que, logo nos primeiros discursos, entrevistas e gestos, foi também se mostrando aos poucos. Neste ano, completam-se já 10 anos do pontificado de Francisco que, mais do que deixar uma herança em termos teológicos, representa, em si mesmo, um rumo para a Igreja, como um grande iniciador de processos. Nesse sentido, este artigo procura resgatar brevemente o histórico de sua vida para apontar o quanto, efetivamente, toda sua vivência e formação contribuíram eficazmente para que, hoje, o Papa realize com tanta coragem o seu ministério, como um filho do Concílio Ecumênico Vaticano II (1962-1965). Ao mesmo tempo, partindo das análises de Ricoeur (1913-2005), apresenta-se o bispo de Roma como um texto, que deve ser interpretado e vivido, concretamente, pela Igreja, a fim de que esta se compreenda sempre melhor e, à luz do que pedia o Concílio, faça também o seu aggiornamento para o século XXI.
paz como harmonia profunda com Deus
Authors: Brechó Nelson Maria , Marinho de Arruda Junior Vamberto , Bueno de Almeida Benedito Antônio
Published: January 2025

Este artigo tem como objetivo refletir sobre a paz em Lucas, através da metodologia da leitura comparativa e interpretativa. Pretende-se, por um lado, apresentar as semelhanças entre o relato da aparição de Cristo ressuscitado e o relato do nascimento de Jesus, em Lucas 2,8-20. Por outro lado, destaca-se elementos como a manifestação divina, o temor, a saudação de paz e a alegria. Nesse contexto, em Lucas 24:36-49, destaca-se a conexão entre a paz com o espanto e o temor. Portanto, a literatura lucana incentiva a comunidade cristã a aprofundar a relação mestre-discípulo através do temor e da alegria na experiência com o Cristo ressuscitado. Essa reflexão possibilita ampliar os horizontes na área exegética diante dos desafios atuais, como a pandemia, as guerras e as polarizações políticas. Dessa forma, a atitude cristã implica ser capaz de aplicar a paz no âmbito comunitário.
Eclesiologia(s) do Concílio Vaticano II
Authors: Gomes Tiago de Fraga , Marques de Jesus Luciano , Agostini Leonardo
Published: January 2025

O Concílio Vaticano II é um divisor de águas na vida da Igreja contemporânea. Ao convocá-lo, o Papa João XXIII sinaliza a necessidade de uma renovação identitária da Igreja, ou seja, de um aggiornamento eclesial. Dos 16 documentos que emanaram deste evento, a presente pesquisa debruçar-se em uma abordagem teórico-bibliográfica sobre dois deles: a Lumen Gentium e a Gaudium et Spes, textos de especial relevância eclesiológica e pastoral. Pretende-se apresentar um breve contexto da convocação e da finalidade do Concílio Vaticano II, para em seguida, traçar alguns apontamentos sobre a recepção e a hermenêutica conciliar, para, por fim, abordar algumas das eclesiologias do Concílio Vaticano II e a sua importância para a caminhada da Igreja na atualidade.
Discursos do Cardeal Tolentino
Authors: Tolentino de Mendonça Cardeal José
Published: January 2025

Por ocasião dos 75 anos da Faculdade de Teologia Nossa Senhora da Assunção da PUC-SP, o Cardeal José Tolentino de Mendonça, Prefeito do Dicastério para a Cultura e a Educação, compartilhou uma série de discursos profundos e inspiradores. Destacamos três momentos importantes: Homilia Catedral de São Paulo; Que teologia para o nosso tempo?;  Que recursos espirituais para enfrentar o futuro?
Resenha Crítica sobre a Declaração Dignitas Infinita
Authors: Lima Vilk Junio Araújo de
Published: January 2025

A declaração "Dignitas Infinita" foi oficialmente apresentada ao público em 25 de março de 2024. No entanto, conforme indicado no próprio documento, sua elaboração teve início em 15 de março de 2019, por iniciativa da então Congregação para a Doutrina da Fé. O principal objetivo do documento é enfatizar a importância do conceito de dignidade humana tanto para a Antropologia cristã quanto para a sociedade em geral, especialmente diante dos desafios e ambiguidades conceituais atuais relacionados a esse tema crucial.
The Sudden Cardiac Death Continuum. Message 1
Authors: Lazutkina A. Yu.
Published: January 2025

RELEVANCE Many clinical conditions are considered in a sequence of interrelated events of the continuity of the pathological process. This makes it possible to discover its patterns, specific mechanisms of occurrence and development of the disease. However, the continuum of sudden cardiac death (SCD) remains unknown.

AIM OF THE STUDY To clarify the sequence of events of the continuum of the SCD using the example of initially healthy workers of locomotive crews of the Trans-Baikal Railway.

MATERIAL AND METHODS Based on the material of a 6-year prospective observation of a natural group of 7,959 men aged 18–66 years, predictors of microalbuminuria (MAU), creatininemia (CR), reduced glomerular filtration rate (rGFR), retinopathy (RP), and SCD were determined in 22 positions. A 2×2 table, multivariate regression analysis, and survival analysis were used, and the relative risk of risk factors (RF) was estimated, which made it possible to study and construct a continuum of chronic kidney disease from pre-prepared symptomatic blocks: MAU, RP, CR, rGFR using the synthesis method based on the principle of assembling puzzles, to which the SCD block was added according to this principle.

RESULTS The formation of SCD depends on the set of risk factors in each individual case and can occur from any peripheral point of the SCD continuum (from the risk factor). The formation of SCD is determined by the proximity of the predictor to the outcome, its independent effect and (or) interaction with other risk factors. The most dangerous predictor of SCD is excessive alcohol consumption, which causes damage to the heart and (or) kidneys, closing the dysfunctional circle of re-entry cardiorenal continuum and forming cardiorenal syndrome. In the population, those most at risk of SCD are those with an initially low number of nephrons and (or) a congenital defect of the microcirculatory bed.

CONCLUSION Further study of the continuum of sudden cardiac death is needed to determine whether cardiac or renal involvement is primary and whether the risk of sudden cardiac death increases. cardiac death when each predictor is added to the continuum of sudden cardiac death, the effects of risk factor damage, their increasing power with prolonged exposure, the magnitude of tissue damage, and the probability and timing of sudden cardiac death.
Endothelial Dysfunction in Trauma: Pathogenesis, Clinical Significance, Diagnosis and Treatment
Authors: Matyukhin V. V. , Maskin S. S. , Aleksandrov V. V. , Dudchenko G. P. , Ostrovsky O. V. , Alimov M. N. , Werle O. V.
Published: January 2025

Severe trauma is a major medical and social problem. Severe injures is the leading cause of death in people under the age of 44. Many trauma survivors become disabled. Apart from immediate death of victims at the prehospital stage, in-hospital mortality is usually due to hemorrhagic shock, coagulopathy, systemic inflammation, both infectious and non-infectious nature, and multiple organ failure. In the last decade, a significant role of endothelial dysfunction in the development of these pathological processes has been recognized. Endothelial dysfunction refers to excessive activation of the endothelium, accompanied by multisystem manifestations. This literature review presents current data on the physiology of normal endothelium, the pathogenesis of endothelial dysfunction in trauma, its role in the development of systemic inflammation, increased vascular permeability and coagulopathy, and methods for its diagnosis and correction.
The Impact of the Fibrinolytic System on the Outcomes of Thrombolytic Therapy
Authors: Kalinin R. E. , Klimentova E. A. , Suchkov I. A. , Egorov A. A. , Pshennikov A. S.
Published: January 2025

Thrombolysis is one of the effectively used methods for treating patients with acute vascular pathology. Despite the high technical success of this therapy, some problems of fibrinolytic treatment still remain unresolved. Resistance to thrombolytic agents with subsequent unsatisfactory reperfusion of the vascular bed is the most important of them. Currently, despite advances in the pharmacotherapy of drugs used in thrombolysis and improvements in the technical basis for its performance, the predictors that influence its outcome are still not clearly defined. The use of fibrinolytic drugs during thrombolysis induces activation of the procoagulative component of hemostasis in the form of increased activity of thrombin, prothrombin fragments 1.2 and the thrombin-antithrombin III complex in response to excessive fibrinolysis caused by this treatment method. This paradoxical procoagulant activation of the hemostatic system may be the cause of the lack of initial reperfusion of the vascular bed in 15–25% of cases, and from 5% to 15% of cases of early thrombotic reocclusion after initially successful thrombolysis. In parallel with the activation of the coagulation link of hemostasis against the background of this type of treatment, changes occur in the functioning of the fibrinolysis system, which directly affects the outcomes of thrombolysis. This paper provides a comprehensive overview of the spectrum of major markers of the fibrinolytic system that have been studied in the context of thrombolysis outcomes in patients with acute vascular pathology. It was concluded that it is necessary to expand the determination of laboratory blood parameters by directly determining the values of plasminogen activator inhibitor-1, thrombin-activated fibrinolysis inhibitor, α2-plasmin inhibitor in order to predict the outcome of thrombolysis.
Nitric Oxide Donors in the Treatment of Vascular Spasm and Delayed Cerebral Ischemia in Patients with Subarachnoid Hemorrhage
Authors: Zhuravel S. V. , Prirodov A. V. , Bakharev E. Yu. , Zorin P. D. , Petrikov S. S.
Published: January 2025

Secondary vascular spasm due to non-traumatic rupture of cerebral artery aneurysms is a formidable complication leading to serious disability of patients who face this disease, and in 30–50% of cases leads to death. Standard therapy used in intensive care units does not have tremendous success in the treatment of this pathology, which encourages scientists around the world to search for new drugs that can improve the outcome and increase the quality of life of patients. At the moment, the most promising non-surgical method of treatment is the use of nitric oxide donor drugs as part of complex therapy. In modern medicine, there are several ways to administer drugs of this group: intravenously, intra-arterially , intrathecally , intraventricularly and by inhalation . The method depends on the type of drug used. Despite the promise of using these dosage forms, there are a number of negative side effects, which, due to insufficient study, limit their widespread use in hospitals. This review contains studies examining the positive and negative aspects of the use of these drugs and the appropriateness of their use.
Development of a Model of the System of Organizational Development of Treatment and Diagnostic Processes of a Multidisciplinary Hospital
Authors: Perminov A. Yu. , Fomenko N. S. , Petrikov S. S. , Samarin A. R. , Dragunova N. P. , Maksimov A. I. , Melnikova I. K. , Molodov V. A.
Published: January 2025

The most important factor in improving the quality of medical services at present is the continuous improvement of all aspects of the activities of a medical organization, which determines the appropriateness of using modern approaches to organizational development in medical institutions with their appropriate adaptation.

The paper presents the results of the analysis of 16 known models of organizational development, as well as the performance indicators of the Kaidzen proposal system at 19 Russian and foreign enterprises in various industries. An analysis of the authors’ long-term experience of working with small groups on standardization of treatment and diagnostic processes at the N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department was conducted, which confirmed the assumption that medical personnel of all categories have a large number of ideas for improving the organization’s work and are willing to participate in their implementation.

The article presents the author’s model of the system of organizational development of treatment and diagnostic processes of a multidisciplinary hospital, which is based on the concept of personnel orientation and the basic principles developed by the authors.

In the part of the model detailing, a developed system of classification features is presented, which allows determining the belonging of a proposal for improvement to a certain group or class, as well as the approach proposed by the authors to sorting proposals at various stages of working with them.

The paper presents the results of testing the described approach using the example of proposals for improvement formulated by a pilot group of nurses of the operating unit of the N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department. Conclusions are made on the possibilities of applying the presented research results for medical organizations, as well as promising areas for the development of the presented approach.
Method for Assessing the Degree of External Dislocation of the Catheter for Prolonged Brachial Plexus Block
Authors: Yamshchikov O. N. , Marchenko A. P. , Emelianov S. A. , Ivanova O. D.
Published: January 2025

AIM OF STUDY To demonstrate the effectiveness and safety of a method for assessing the degree of external dislocation of a catheter for continuous brachial plexus block (CBPB) using a dislocation scale in clinical practice.

MATERIAL AND METHODS The study included 63 patients who underwent CBPB from the supraclavicular approach with fixation of the catheter on the skin with a patch sticker during operations for fractures of the bones of the upper limb. To analyze the size of the catheter dislocation, a method for assessing the degree of external dislocation of the catheter for CBPB was used.

RESULTS In 16 patients, the size of the external dislocation was from 0 mm to 5 mm (grade 1), which was assessed as no dislocation, in 30 patients it was more than 5 mm to 10 mm (grade 2), while there were no changes in the quality of pain relief, in 15 patients the dislocation was more than 10 mm to 15 mm (grade 3), while there was a deterioration in the quality of pain relief, it was necessary to increase the dose of the administered local anesthetic and strengthen the fixation of the catheter to the skin of the supraclavicular region with a fixation device, in 2 patients the size of the external dislocation was more than 15 mm (grade 4), which was defined as migration of the catheter beyond the brachial plexus and led to the cessation of CPBP.

CONCLUSION The physician operating the catheter for prolonged brachial plexus block, using the method of assessing the degree of external dislocation, has the opportunity to determine the likelihood of deterioration in the quality of anesthesia based on the size of the dislocation and prevent its cessation.