bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Assessment of a MPID controller in Microgrid Systems for Load Frequency Control
Authors: Mishra Debashish , Chandra Nayak Pratap , Jally Prgatibala , Lenka Chandan
Published: April 2024

This study provides a novel methodology to design an A.C. off-grid multi-microgrid (MMG) system and suggests an analytical method for load frequency management utilizing a multistage PID (MPID) controller based on the sine cosine algorithm. The unique benefits of an MMG system are similar to those of renewable energy sources (RES), such as solar system models, wind turbine models, etc. There is a conflict between the MMG system's source and the load requirement because of the erratic properties of renewable energy sources. The irregular nature of renewable energy sources has an impact on the frequency of the system. Therefore, it is very difficult these days to check the frequency in a MMG system. This article uses the SCA-based MPID to tune the controller parameter for secondary frequency control, despite all of the complexity. In the power system, LFC (load frequency control ) is achieved by regulating active power. The dynamic response of the conventional PI-PID controller has been used to assess the effectiveness of the proposed MPID controller. Using the sine and cosine approaches, the parameters are optimized.
Avanços Contemporâneos na Compreensão da Fisiopatologia, Diagnóstico e Tratamento da Hiperplasia Prostática Benigna: Uma Revisão Abrangente.
Authors: Cabellino Luíza Fricks , Oliveira Vimercati Jhennifer , Cazotti Thiengo Pedro Gabriel , Tannure Sanches Emanuella , Marcelino de Lima Jani Sara , Nogueira Freire Laura , Pessin Manzoli Fabio , Giacomin Amanda , Grilo Vincentini Henrique , Riquieri Donato Isadora , Vieira Vargas Heloísa , Cosenza Paixão Souza Anna Paula , Da Silveira Reis Laura , Castelioni Trés Mendes Julia , Giacomin Moreira Laura , Abu Dioan Layla Miguel
Published: April 2024

A próstata humana, um órgão em forma de pirâmide próximo à bexiga, desempenha um papel crucial na produção do fluido seminal. A hiperplasia prostática benigna (HPB), um crescimento não canceroso das células da próstata, é comum em homens acima de 40 anos, afetando significativamente a qualidade de vida. A HPB não está relacionada ao câncer de próstata, mas pode causar sintomas urinários irritativos e obstrutivos, como diminuição do fluxo urinário e urgência miccional.
A prevalência da HPB aumenta com a idade, afetando até 90% dos homens na oitava década de vida. O diagnóstico precoce é fundamental, com a triagem recomendada para homens entre 55 e 69 anos, considerando fatores de risco individuais e antecedentes familiares. O toque retal e a dosagem de PSA são métodos de triagem essenciais, embora o PSA possa ter limitações de especificidade.
O tratamento da HPB pode envolver abordagens farmacológicas e cirúrgicas. Os bloqueadores alfa-adrenérgicos e os inibidores da 5-alfa-redutase são comuns para aliviar sintomas e reduzir o tamanho da próstata. Em casos mais graves, intervenções cirúrgicas, como a ressecção transuretral da próstata (RTUP) e a prostatectomia aberta, podem ser necessárias.
A pesquisa contínua é essencial para desenvolver novas estratégias de manejo da HPB, especialmente com o envelhecimento da população, prevendo-se um aumento na incidência da doença. Uma abordagem multidisciplinar, incluindo avaliação física, exames laboratoriais e de imagem, é crucial para determinar o melhor curso de tratamento para cada paciente.
Doença pulmonar obstrutiva crônica: fatores de risco, exacerbações e implicações terapêuticas.
Authors: Vytor Cardoso Nobre Paulo , Maria Silva Cavalcante Flávia , Da Silva Santos Lorena , Letícia Néri Marques Ana , Natália Gomes Quintino de Holanda Cavalcante Rosângela , Malta Brandão Nunes Alina , Malta Brandão Fireman Gustavo , Amorim Ferreira dos Santos Camila , De Freitas Melo Oliveira Yasmin , Rabelo Magalhães Martins Leticia , Regina de Andrade Lima Morgana , Cantarelli Primo de Carvalho Pedro
Published: April 2024

Introdução: A Doença Pulmonar Obstrutiva Crônica (DPOC) é uma condição de alcance mundial caracterizada pela presença persistente de inflamação crônica das vias aéreas, resultando em uma progressiva restrição do fluxo aéreo. Objetivo: Avaliar os fatores de riscos, exarcebações e aspectos terapêuticos da doença pulmonar obstrutiva crônica.  Metodologia: Trata-se de uma revisão bibliográfica que incluiu artigos originais e revisões sistemáticas em inglês e português, que abordaram os fatores de risco para exacerbações e manejo da DPOC, publicados entre 2015 e 2024, selecionados nas bases de dados PubMed, Scopus e SciELO. Após a seleção criteriosa, foram escolhidos 20 artigos para compor esta revisão bibliográfica. Resultados: Há diversos fatores de risco que contribuem para o quadro, como Infecções bacterianas e virais, tabagismo, poluição atmosférica e exposição à biomassa residencial. O manejo inclui intervenções farmacológicas e não farmacológicas, com ênfase na cessação do tabagismo como uma prioridade central. A abordagem farmacológica inclui agonistas beta-2, antimuscarínicos e corticosteróides. Considerações: A abordagem da DPOC requer um entenimento amplo dos fatores de risco que exacerbam o estado clínico e contribuem para hospitalizações recorrentes. Estratégias de manejo, incluindo intervenções farmacológicas e não farmacológicas, com ênfase na cessação do tabagismo, são essenciais. O tratamento farmacológico, demonstrou ser eficaz, principalmente a terapia tripla, sendo crucial para reduzir exacerbações e melhorar a qualidade de vida dos pacientes com DPOC.
Ecosystem interoperability for the architecture, engineering, construction & operations (AECO) sector
Authors: Doe Robert , Kaur Karamjit , Selway Matt , Stumptner Markus
Published: April 2024

Substandard performance between information systems and applications remains a problem for the Architecture, Engineering, Construction, and Operations (AECO) sector leading to significant economic, social and environmental costs. The sector suffers from poor interoperability because it lacks a holistic ecosystem for exchanging data and information. Through qualitative research involving AECO sector industry partners’ views and opinions, this research extends understanding of issues which affect ecosystem interoperability in the AECO sector. Research questions guided a literature review, survey, semi-structured interview, focus group meeting, and interpretation of the results. The authors believe that incorporating AECO sector industry partners' views is essential for meaningful proposals to emerge. Open questions asked of industry partners received candid responses and confirmed key issues including: the need for the Industry Foundation Class (IFC) to be fully interoperable; the side effects and impacts of vendor lock-in; integration problems caused by multiple Common Data Environments (CDEs); handover data and information challenges; the impacts of poor interoperability on sustainable development. Through engagement with industry this research offers better understanding of interoperability challenges in the AECO sector and has generated more meaningful actions and solutions capable of improving the sector’s data and information ecosystem.
URBANIZATION IN INDIA: AN EVALUATION FROM ENVIRONMENTAL PERSPECTIVES
Authors: Dr. Aakuthota Srinivasulu
Published: April 2024

Urbanization is a process taking place globally intertwined with economic development. Urbanization is a process that leads to the growth of cities due to industrialization and economic development, and that leads to urban- specific changes in specialization, labor division and human behaviors. Urbanization refers to general increase in population and the amount of industrialization of a settlement. The population is growing at the rate of about 17 million annually which means a staggering 45,000 births per day and 31 births per minutes. If the current trend continues, by the year 2050, India would have 1620 million populations. It includes increase in the number and extent of cities. It symbolizes the movement of people from rural to urban areas. Urbanization happens because of the increase in the extent and density of urban areas. The most emerging issues are climate changes, freshwater scarcity, deforestation, and fresh water pollution and population growth. Although it is impossible to restrict urbanization it has to be ensured that urbanization proceeds in the right path causing minimum impact on environment.
KEYWORDS: Urbanization, Environmental, Growth, scarcity, deforestation
Midwife to Mid Wif: A Study in Caseload Midwifery
Authors:   , Stevens Trudy
Published: April 2024

This thesis explores the implications of individual caseload practice for midwives. Over the past fifty years childbirth in England has become predominantly hospital oriented, with midwives forced to meet the needs of the institution rather than those of childbearing women. In 1994 a change in government policy for the materinity serives attempted to address the dissatisfaction felt by mothers and midwives. The model of caseload midwifery was developed from their recommendations. This study explores the implementation of caseload midwifery within a highly medicalised inner-city NHS maternity service. Working in partnership, within small groups, each midwife carried a caseload of 40 women per year. No longer based in the conventional hospital or community services, the midwife worked where and when appropriate, to meet the needs of these women. The research was undertaken over 46 months using the ethnographic approach. A variety of data collection methods and analyses were used iteratively, in a process of responsive focusing.
Purification and Antimicrobial Properties of Oleuropein.
Authors:   , Cinar Dursun
Published: April 2024

Olive leaves contain substantial amounts of phenolic substances, including the polyphenol oleuropein. This compound has been reported as containing antimicrobial properties. The purpose of this study was to develop an improved method for the extraction and purification of oleuropein from olive leaves and characterise its activity as well as the mode of action against a range of bacteria.
The Relationship between Outcomes and Midwifery models
Authors:   , Harvey Sheila
Published: April 2024

Since the 1970s attitudes towards childbirth have been changing as a results of women's and midwives' desire for a more natural approach. This thesis assesses the appropriateness of midwifery as a model for maternity care and explores the differences between models of midwifery and their relationship to the birth experiences of women and babies. The Alberta model provided the main focus to the exploration.
ANALISIS PENGARUH HARDBALL STRATEGI (DESAIN PRODUK, TAGLINE DAN PESAN IKLAN) TERHADAP KEPUTUSAN PEMBELIAN ADES DI KABUPATEN JEMBER
Authors: Amalia Cinthia Dwi , Azhad Muhammad Naely , Rahayu Jekti
Published: April 2024

This research aims to determine the influence of product design, taglines and advertising messages as hardball strategies on purchasing decisions for Ades Jember drinking water. This type of research is quantitative. The population in this study were all Ades drinking water consumers in Jember using the Ferdinand formula sampling technique. The data source in this research uses primary data, namely questionnaires. Data were analyzed using multiple linear regression, normality test, multicollinearity test, heteroscedasticity test, t test, f test, and determination test which were carried out computationally with the SPSS program. The results of this research show that product design, taglines and advertising messages have a positive and significant effect on purchasing decisions for Ades Jember drinking water.
Educationis Momentum Vol. 9, n.° 1, diciembre del 2023
Authors: San Pablo Universidad Católica
Published: April 2024

En el marco de una crisis sanitaria, el único órgano local encargado de promover la participación ciudadana en la gestión educativa, el Consejo Participativo Local de Educación (Copale), estuvo inactivo. Este fue el punto de partida para explorar las formas de comunicación y participación en la gestión educativa de una comunidad en Mórrope, distrito situado al norte del Perú, durante la pandemia de la COVID-19. A partir de un enfoque fenomenológico-cualitativo basado en entrevistas y análisis documental se revelaron procesos de participación e interacciones comunicacionales naturales no regulatorias, evidenciando escenarios positivos, como el papel de los actores comunitarios al abordar diversos problemas logísticos: búsqueda de estudiantes «no contactados», distribución de alimentos de Qali Warma o desarrollo de las sesiones de aprendizaje virtual. Sin embargo, se observaron también escenarios negativos como las prácticas comunicativas verticales desde el Estado. Finalmente, se examinó la percepción de los directivos de la Unidad de Gestión Educativa Local (UGEL) sobre la participación ciudadana, contrastándola con la realidad observada. Las experiencias recopiladas destacan la importancia de la participación comunitaria como eje en la gestión educativa e invitan a repensarla no solo como un conocimiento directo de las necesidades locales, sino como una cuestión de justicia social.
THE PERM INTELLIGENT VIEWER AT THE MEETING WITH HIGH MUSICAL ART (BASED ON THE MATERIALS OF THE ANTHROPOLOGICAL RESEARCH IN PERM)
Authors: MANTOROVA ANNA
Published: April 2024

The article examines the image of the Perm musical theatrе's viewer, formed in the theatrical environment of the regional center in 2011-2019. It was established that the myth designed by the artistic director of The Perm Tchaikovsky Opera and Ballet Theatre allows the neophyte to enter the traditionally closed world of classical music by building a specific plot (the logic of the fairy tale). The methodology is based on the concept of V. Ya. Propp. Using its language, the author indicates the stages of the intelligent viewer’s entry into the world of musical theatre. The process of becoming the viewer is based on the concept’s key elements (rite of passage - the madness of the neophyte - mastering the “cunning science”), which exist in the form of the plot’s “embryos” in the personal mythology of T. Currentzis. The main mythological motifs and images read by viewers influence the formation of their own practices of self-presentation. Focused interviews with viewers in Perm, which were conducted by the author in 2016-2019, are used as a source.
IMAGES-SYMBOLS OF TRADITIONAL ARTISTIC CRAFTS IN THE FORMATION OF THE CULTURAL CODE OF THE CITY
Authors: PLAVINSKAYA LIDIA
Published: April 2024

The article is devoted to the analysis of the use of images-symbols of traditional applied arts for the Ryazan region (embroidery, lace weaving, weaving) in shaping the appearance of the city, reflecting its cultural code. Based on semiotic studies of the phenomenon of the concept in question, the author aims to trace the ways of symbolic expression of the cultural code of the city and their role in creating the mental sphere of culture in the elements of the urban environment. The assumption that the formation of the cultural memory of the city is carried out in two interrelated directions, allowing you to feel involved in your own history, culture and create unique images-symbols characterizing the cultural values of a particular region in order to identify it, is confirmed in the extensive illustrative material of the article. The author explores both historically established ways of broadcasting such elements in the urban environment (architraves, house decorations, bridge fences), stylized as recognizable elements of lace weaving, embroidery, weaving, and modern elements of urban space (design of fountains, light structures, festive decorations) with these symbols expressing the cultural memory of the city. The techniques used to identify a place from the point of view of its history and culture through characteristic, iconic elements in traditional applied art, lead the researcher to the conclusion that symbolic images can be not only markers that increase the level of patriotism of the city's indigenous inhabitants, but also business cards of the city, which are part of the geocultural space, capable of forming, including tourist the area code, which increases the importance of semiotic research in the framework of the formation of a cultural spatial environment.
Critical Thinking In Learning Perspectives On Educational Philosophy
Authors: Pauzi Pauzi
Published: April 2024

Students are encouraged to enhance their analytical and evaluative skills through critical thinking, an essential component of education. This publication aims to investigate the significance of critical thinking in the context of learning, with a particular emphasis on educational philosophy views. This article examines the philosophical perspectives underpinning critical thinking, defines the relationship between those perspectives and academic goals, and assesses the impact these perspectives have on pupils' intellectual and moral growth. A method of research that takes a qualitative approach. Examining the ideas of epistemology, logic, and methodology that form the basis of critical thinking is accomplished through applying a philosophical perspective. To provide theoretical contributions to the debate over the function of critical thinking in the educational process, the discussion encompasses perspectives from ancient and modern philosophers. Additionally, the practical consequences of an educational philosophy perspective on the creation of curricula and teaching methods that support the development of critical thinking in students are discussed in this article.
Towards Islamic Pedagogy By Exploring The Applications Of Educational Technology
Authors: Yunita Yunita , Mulyadi Mulyadi
Published: April 2024

Islamic education has long been an integral part of the Muslim intellectual tradition. However, new challenges and opportunities emerge in strengthening Islamic pedagogy in the current digital era. This article aims to explore how integrating technology in the context of Islamic education can enrich learning experiences and develop pedagogy connected to Islamic values. Through a literature review, we explore various educational technology applications that can be used to improve Islamic-based learning. We highlight the implementation of technology, such as interactive learning applications, e-learning platforms, and social media, that can facilitate discussion and collaboration between students and educators. In addition, we analyze Islamic pedagogical principles that can be integrated into developing and using educational technology. Concepts such as active participation, collaborative learning, and student-centered learning experiences are considered in the context of Islamic values such as justice, compassion, and example. Through this approach, technology in Islamic education will increase the efficiency and effectiveness of learning and respect and strengthen the spiritual and moral values that underlie Islamic education. Future research can explore the practical implementation of Islamic pedagogy connected to technology in formal and non-formal educational contexts and evaluate its impact on achieving the goals of Islamic education.
The Importance of Prayer in Shaping Muslim Character According to Quraish Shihab
Authors: Oktaviani Sri , Rhamadhan Yasvina
Published: April 2024

This research aims to determine the importance of prayer and the values contained in it. This research uses a qualitative research method used to research the condition of natural objects, where the researcher is the key instrument, data collection techniques are carried out in a combined manner, data analysis is inductive, and the results of qualitative research emphasize meaning rather than generalization. With this type of research, or library research, Prayer is the base and foundation of religion; prayer is one of the most effective ways of approaching Allah. In prayer, there are many values contained and can shape the character of a Muslim, and these values are: 1) Prayer is a means of getting closer to Allah and soothing the soul; 2). Prayer builds a clean and orderly person. 3) Prayer creates patient character, so from here, the role of prayer is very important for Muslims. Apart from being a way to get closer to Allah, prayer is also a character builder because there are many values that can be learned there.
Integration of the Movement to Spread Islamic Teachings in Answering the Challenges of the Modern Era and Technological Development
Authors: Sopiyan Wawan , Hidayat Rahmat , Marzuki Muhammad , Mislawaty Sri Eva
Published: April 2024

Abstrak
Kemajuan arus modernisasi yang bersamaan dengan kemajuan ilmu pengetahuan teknologi (IPTEK) akan semakin mewarnai komunikasi ataupun hubungan yang berlangsung di masyarakat secara luas. Terlebih kembali kehidupan beragama yang itu merupakan inti sendi manusia di dalam menjalankan aktifitasnya di masa modernisasi ini. Upaya dan langkah perfentif di dalam membersamai perkembangan arus modernisasi ini adalah dengan selalu memperhatikan kaidah-kaidah nilai dan implementasinya bagi kehidupan. Ditambah konsentrasi para pegiat dakwah untuk terus memperhatikan terbarukannya pola dan dinamika penyampaian pesan agama, baik metode, strategi, dan sikap di dalam mengantisipasi kecenderungan masyarakat. Da’I dalam hal ini  harus terus dituntut selalu menginofasi motodeloginya di dalam menyampaikan pesan-pesan dakwah. Sebab perkembangan zaman dan globalisasi akan mudah menggerus pola-pola lama dan menghilang jikalau tidak ada upaya di dalam menginofasinya secara efektif. Penelitian ini adalah upaya peninjauan integrasi strategi dakwah era modern yang dinamis seiring dengan perubahan zaman. Dengan mengedepankan kualitatif deskriptif sebagai tabulasi dan kemasan datanya adalah literature riview atau kajian pustaka (library reaserch). Dengan luaran adalah da’I mampu mengintegrasikan arus modernisasi ini kedalam dakwahnya. Sehingga dakwah ini tetap bernilai pesan Islamnya, namun juga tidak meninggalkan perkembangan pengetahuan dan teknologi yang dijadikan sebagai alat (wasilah dakwah). Artinya pendakwah mampu turut dan ikut serta di dalam meramaikan perkembangan zaman yang berupaya menjelaskan syariat Islam dari sisi modernisnya. Dan orientasi dakwah di era ini adalah bagaiman pendekatan dakwah kepada mad’u yang secara notabene adalah akumulasi masyarakat modern dengan mengikuti trend masyarakatnya. Dengan menggunakan metode bi al tadwin atau pemanfaatan media dan langkah perfentif pendekatan bil hikmah wal mauizah hasanah. Selaras dengan da’I merupakan individu yang harus juga mampu menguasai wawasan materi, metode, media, IPTEK yang relevansi penyampaian pesan dakwah kepada mad’u adalah masyarakat modern.
Kata Kunci: Integrasi Gerakan Dakwah, Modernisasi dan Perkembangan Teknologi
Aproximaciones consecuentes
Authors: Herrera Casilimas Juan Camilo , Dávalos Franklin , Barco Largo Melissa
Published: April 2024

El artículo expone la indagación de Baldío y Humaxs Humus, procesos de investigación-creación concebidos respectivamente por Natalia Orozco y Zoitsa Noriega, coreógrafas de danza contemporánea de la actual escena bogotana, con el fin de reconocer sus metodologías, los elementos particulares y transversales de las mismas, así como su relación con los contextos en que tienen lugar.  
La investigación-creación implica el empleo de metodologías o estrategias que pueden entenderse como formas subjetivas de organización del conocimiento que atienden a la naturaleza cambiante de los procesos de creación artística, que no necesariamente se inscriben dentro de un modelo metodológico estable, sino que, de acuerdo a las necesidades, intereses e intuiciones de cada artista, migran entre los campos del arte, la ciencia y otras ramas del conocimiento, generando procesos que van más allá de lo disciplinar. Por lo tanto, con el fin de entender la razón de ser de los procesos seleccionados y reconocer en ellos los procedimientos particulares que los atraviesan, se opta por realizar una investigación narrativa, en la que el relato de las creadoras en torno a su proceso creativo constituyen el insumo principal.
Wolfgang Amadeus Mozart La flauta mágica
Authors: Aranda Espinosa Francisco
Published: April 2024

Este ensayo filosófico aborda un análisis especulativo e interdisciplinario sobre la ópera La flauta mágica, de W. A. Mozart, KV 620, estrenada el 30 de septiembre de 1791, en el Theater auf der Wieden, en Viena, Austria. Decimos que el enfoque de este escrito es interdisciplinario porque combina el análisis musical con la hermenéutica, la historia y la filosofía de la música, para así ofrecer al lector una visión más amplia para acceder y comprender de mejor manera el contexto, argumento, libreto y cosmos musical operístico, que tiene por naturaleza las mismas características de la multidisciplina. La flauta mágica, perteneciente al género del singspiel alemán, nace a partir de la colaboración filosófica, musical y religiosa entre Mozart y Emanuel Schikaneder, compañeros en la logia masónica La Beneficencia y que, en en el período de 1790 a 1791, vivían un momento económicamente complicado. A través de estas líneas se propondrá una lectura de la ópera a partir de su composición musical, libreto, argumento, ideas religiosas, contexto social e histórico y lo que de ello se deriva, desembocando en una reflexión filosófica que no pretenderá dar con una verdad absoluta sino, más bien, intentará invitar al lector a sumergirse en las profundas concomitancias que surgen de la obra mozartiana a tratar.
Suitability and characterization of pumice, bauxite, and ferrochrome slag as alternative raw materials in vitrified ceramic industry
Authors: Benkli Yunus Emre , Koca Kazım
Published: April 2024

Since the natural raw materials used in the manufacture of clay-based ceramic products vary greatly in the sintering stage, the resulting products are quite heterogeneous. In addition, different types of waste could be used to make ceramic tiles and bricks. Therefore, this study aimed to investigate the effects of pumice, bauxite, and ferrochrome slag on the vitrified ceramic body. In this context, firstly, binary slip mixtures were prepared by composing 40% clay with 60% pumice, bauxite, and ferrochrome slag one by one, which was reduced to 150 µm in particle size. Then, the mixtures were shaped by slip casting method and sintered at 1000°C, 1100°C, 1200°C, and 1250°C. The qualitative XRD analysis was performed in order to see the phase variation, and physical properties were determined with shrinkage and water adsorption measurements. Since pumice transformed into a glassy phase after sintering at 1100°C, an amorphous phase was observed in all samples produced with pumice. In addition, the mullite development occurred in clay-pumice body composition with the temperature increment. However, tridymite and cristobalite phases were analysed in clay bauxite and ferrochrome body compositions. The shrinkage and water adsorption values, which were high in the samples sintered at 1000°C, began to reduce from 1100°C to 1250°C significantly. In particular, water adsorption reached 0% in the clay-pumice system which was suitable for a fully vitrified-high density standard (ISO13006-10545/98). Besides, the brighter colour was reached in the clay-pumice system while brown and black colour was seen in clay-bauxite and clay-ferrochrome bodies, respectively.
A Fixed Point Theorem for Time-Fractional Fornberg-Whitham Equation Arising in Atmospheric Science
Authors: Kumar Badsara Ashok , Chouhan Virendra Singh
Published: April 2024

In this paper, we apply the Homotopy perturbation transform method of the time-fractional Fornberg-Whitham equation with Caputo-Fabrizio fractional derivative. We establish the existence and uniqueness solutions of the time-fractional Fornberg-Whitham equation using fixed point theory. The physical interpretation of the nonlinear models are also discussed through the semi analytical solutions, which demonstrate the effectiveness of the proposed method. Finally, 2D and 3D graphs of some derived solutions are depicted through suitable parameter values.
Rhubarb Extract Exerts Antisepsis Effects by Regulating Inflammation and Apoptosis Signaling Pathways
Authors: Lu Xinxing , Liu Yigao , Gao Chao , Wu Xiao , Yuan Xueyan , Liu Airan
Published: April 2024

The potential targets and signaling pathways of emodin in rhubarb extract in the treatment of sepsis were still unclear. In this research, we identified the intersection genes for sepsis and emodin. The predicted targets were imported into the STRING online platform to construct a protein–protein interaction network of disease targets. DAVID was used to perform enrichment analysis on potential target information. AutoDockTools software was used for molecular docking and visual analysis. By mapping sepsis targets to emodin latent therapeutic targets, 53 co-acting targets were obtained. The biological processes mainly involved include protein phosphorylation and negative regulation of the apoptosis process. The mainly involved cellular components are the cytoplasm, mitochondria, mitochondrial outer membrane, etc., and they mainly involve molecular functions such as enzyme binding, the same protein binding, and protein kinase activity. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed the inflammation-related signaling pathway and the apoptosis signaling pathway as the primary pathways. In conclusion, emodin in rhubarb extract may exert antisepsis functions mainly by affecting inflammation and apoptosis signaling pathways.
CLINICAL AND IMMUNOLOGICAL FEATURES OF REACTIVATION OF CHRONIC LYME BORRELIOSIS AFTER A PREVIOUS INFECTION OF COVID-19
Authors: Hospodarskyi Ihor , Boiko Tetiana
Published: April 2024

A clinical case of reactivation of chronic Lyme borreliosis after a COVID-19 infection has been described.
The purpose of the study is to use the example of a clinical case of reactivation of chronic Lyme borreliosis to demonstrate the peculiarities of its course, and modern methods of diagnosis and treatment, as well as to confirm the potential impact of coronavirus disease on the possibility of reactivation of chronic infectious pathology, even with a mild course of the COVID-19 infection.
Materials and Methods. A diagnosis of borreliosis polyarthritis and Lyme myocarditis has been established. Since the specific lesions occurred for no apparent reason, and the symptoms appeared in winter, this ruled out the possibility of re-infection with Lyme borreliosis. During the further search for a potential causative agent that led to the detected changes, the patient was tested for the detection of antibodies to Borrelia burgdorferi by immunoenzymatic analysis.
Results and discussion. The obtained positive result in the detection of specific antibodies (IgM – 46.64 units/ml, IgG – 87.31 units/ml) indicated the reactivation of Lyme borreliosis. At the same time, the immunological changes were significantly deeper than during the initial episode of infection.
Treatment was prescribed: doxycycline 100 mg twice a day for 28 days, anti-inflammatory therapy. After completion of the course of etiotropic therapy, there was clinical remission, as well as negative results of specific IgM after 3, 6, and 12 months. Even 3 months after achieving clinical remission, the patient had residual immunological changes.
Conclusion. So, the clinical case shows the difficulties of establishing a diagnosis of reactivation of Lyme borreliosis, and the need for clinical vigilance of practical healthcare specialists regarding similar cases, even with a mild course of the COVID-19 infection, is emphasized.
ВМІСТ В ПЕРИФЕРИЧНІЙ КРОВІ В-КЛІТИН «ПАМʼЯТІ» У ВЗАЄМОЗВʼЯЗКУ З РІВНЕМ АНТИТІЛ ДО ДИФТЕРІЇ ТА ПРАВЦЯ У ОСІБ, ЩО ПЕРЕХВОРІЛИ НА ВЕБ-ІНФЕКЦІЮ
Authors: Liadova Tetiana , Popova Alisa
Published: April 2024

Метою даної роботи було вивчити вміст в периферичні крові В-клітин «пам’яті» у взаємозв’язку з рівнем цитокінів, які регулюють активність клітин «пам’яті» та рівнем антитіл до дифтерії та правця у осіб, що перехворіли на ВЕБ-інфекцію.
Матеріали і методи. Для визначення рівня АТ до дифтерії та правця у осіб (18-22 р.), що перехворіли на ВЕБ-інфекцію, було обстежено 79 дорослих, що перехворіли на ІМ і 25 дорослих, що перехворіли на ХВЕБІ. Контрольну групу склала 41 особа. Рівень АТ до дифтерії та правця вимірювали методом ІФА. Захисний рівень АТ до цих інфекцій, відповідно до рекомендацій ВООЗ, вважали >0,1 МО/мл. Вміст в периферичній крові В-клітин «пам’яті» (CD22+CD27+) і рівень ІЛ-15, ІЛ-2, ІЛ-23, ІЛ-10 було вивчено у 19 осіб, що перехворіли на ІМ і 16 осіб, що перехворіли на ХВЕБІ, у яких в крові не спостерігалось захисного рівня АТ одночасно до дифтерії та правця, у 26 осіб, що перехворіли на інфекційний мононуклеоз і у 16 осіб, що перехворіли на ХВЕБІ, у яких був захисний рівень АТ до цих інфекцій. Контрольну групу склали 20 осіб, які були щеплені згідно календаря вакцинації.
Вміст В-клітин «пам’яті» (CD22+CD27+) вимірювали методом проточної цитофлюорометрії на апараті FACS-Calibur (США), рівень інтерлейкінів визначали методом ІФА.
Результати та обговорення. У осіб, що перехворіли на інфекційний мононуклеоз, захисного рівня АТ одночасно до дифтерії та правця не було у 29,1% з 79 обстежених. У осіб, які перехворіли на ХВЕБІ, захисний рівень АТ до цих інфекцій не реєструвався у 64% обстежених. В контрольній групі осіб захисного рівня АТ до правця не було у 12,1%, до дифтерії – у 26,7%.
У осіб, які перехворіли на ІМ і не мають захисного рівня АТ до дифтерії та правця, вміст В-клітин «пам’яті» був на 12,8% нижче, ніж у осіб, що перехворіли на ІМ і мають захисний рівень АТ до цих інфекцій. У осіб, що перехворіли на ХВЕБІ і не мають захисного рівня АТ до дифтерії та правця, вміст в крові В-клітин «пам’яті» на 18,4% нижче, ніж у осіб, що перехворіли на ХВЕБІ і мають захисний рівень АТ до цих інфекцій, і на 40,8% нижче, ніж у осіб контрольної групи. Рівень цитокінів (ІЛ-15, ІЛ-21, ІЛ-23), які контролюють і регулюють активність клітин «пам’яті» у осіб, що перехворіли на ІМ і ХВЕБІ і не мають захисного рівня АТ до дифтерії та правця, вірогідно нижче, ніж у осіб, що перехворіли на ВЕБ- інфекцію із захисним рівнем АТ.
Висновки. ВЕБ-інфекція здатна викликати не тільки імунодефіцитний стан і пригнічувати загальну імунореактивність організму, але і знижувати специфічний поствакцинальний імунітет.
Низький рівень АТ до дифтерії та правця у осіб, що перехворіли на ВЕБ-інфекцію, щільно корелює з низьким вмістом в периферичній крові В-клітин «пам’яті» і низьким рівнем імунорегуляторних цитокінів.
Після перенесення ВЕБ-інфекції доцільним є вимірювання рівня антитіл до керованих інфекцій і в разі їх низького рівня або відсутності захисного рівня рекомендувати позачергове щеплення.
КЛІНІКО-ЛАБОРАТОРНА ОЦІНКА СТАНУ ПАЦІЄНТІВ З РЕВІЗІЙНОЮ РИНОПЛАСТИКОЮ
Authors: Zhuravel Oleksii , Zaporozhets Tetiana , Khrapach Vasyl
Published: April 2024

Вступ. Ринопластика вважається найбільш вибагливою операцією в хірургії обличчя. Ревізійні ринопластики виконуються досить часто, існує чимала кількість технік та методик, але все одно існують проблеми в реабілітаційному процесі.
Головною метою нашого подальшого спостереження стало виявити чинники, які негативно впливають на відновлення носа після операцій, провокують довготривалі набряки, порушення лімфодренажу, провокують фіброзування шкіри та погіршують трофіку шкіри.
Матеріали і методи. Під наглядом знаходилося 63 пацієнти, яким було проведено ревізійну ринопластику з використанням реберного трансплантату. Усім пацієнтам проводили загально- клінічні аналізи крові: загальний аналіз крові, коагулограма, біохімічний аналіз крові, аналізи на інфекційні захворювання (гепатити В, С, ВІЛ- інфекцію, сифіліс) та оцінку рівня цитокінів TNF-α, TGF-β1 (“DRG Diagnostic Inc.”, Німеччина).
Результати та обговорення. У 50,8% пацієнтів з ревізійною ринопластикою виявлено підвищений рівень фібриногену. У цій групі спостерігається збільшення концентрації цитокінів М1-профілю макрофагів (TNF-α) і зниженням концентрації цитокінів М2-профілю (TGF-β1). У хворих із ревізійною ринопластикою, у яких рівень фібриногену був у нормі, характеризується відсутністю змін концентрації в сироватці крові цитокінів М1- (TNF-α) і М2- (TGF-β1) профілю.
Висновки. У зв’язку з виявленими особливостями рівня цитокінів, метою подальших досліджень є оцінка фонового рівня маркерних цитокінів крові у пацієнтів з ревізійною ринопластикою та вивчення системного імунологічного налаштування. Розуміння патогенетичних механізмів розвитку ускладнення після ринопластики дасть можливість розробити ефективні схеми щодо діагностики та профілактики ускладнень в післяопераційному періоді у пацієнтів, яким проводиться ревізійна ринопластика на реберному імпланті.
Impacto de la implementación de un robot programable en la enseñanza de la programación en el nivel medio: un estudio de caso
Authors: Calderón Sebastián , Da Silva Octavio , Bournissen Juan Manuel , Cecilia Tumino Marisa
Published: April 2024

Últimamente, en varios países se observa la incorporación de la programa- ción en la educación primaria y secundaria. Los estudiantes pueden volverse pro- tagonistas de su propio aprendizaje mediante la programación, la cual, junto con otros factores, fomenta la resolución de problemas y el desarrollo del pensamien- to abstracto y computacional. La enseñanza de la ciencia de la computación es esencial para preparar a futuros profesionales. La robótica brinda oportunidades de diseño y construcción que atraen el interés de los estudiantes. Este proyecto evalúa Mulita, un robot educativo programable de pequeño tamaño, resistente y económico, diseñado localmente. Esto permite a los profesores de educación secundaria introducir la robótica en sus aulas y respaldar la educación técnica en diversas disciplinas de manera accesible. Mulita se utilizó en una institución educativa argentina, durante tres años, evaluando sus resultados, las reacciones de los alumnos y el proceso de aprendizaje de programación. Se consideraron las opiniones del docente para mejorar el diseño del robot y el impacto sobre el aprendizaje de los alumnos que interactuaron con él. El docente evaluó (a) la utilidad de Mulita para fortalecer las estrategias didácticas en la enseñanza de programación, (b) su experiencia general, (c) las estrategias de enseñanza y aprendizaje para involucrar a los alumnos y fomentar su creatividad, (d) las reacciones y los resultados de los alumnos durante la implementación y (e) la influencia de la capacitación o el apoyo sobre estos resultados.
Prediction of the Residual Resource of Pneumatic Tire Materials from Accumulation and Type of Damage
Authors: Dmitriev Dmitry , Chursov Serhii , Rusanov Serhii
Published: April 2024

The present paper examines the mechanical characteristics at the boundary of the distribution of rubber matrix and metal and fabric fibrous materials as a distinct area in the crack braking mechanism, and their impact on the durability of pneumatic tires in the event of damage accumulation during operation. Experimental studies were conducted on the delamination of the components of the tire material composition in samples obtained from diverse locations of the car tire. The strength of the rubber matrix fibers of the metal cord was determined, which makes it possible to assess the overall strength of the tire material as a composition of reinforcing elements and the matrix during the accumulation of damage created artificially during operation. The method of experimental research is reasonably stable. The nature and behavior of the sample rupture during the tests were evaluated.
Backstepping Control of an AC/DC/AC Converter in a Grid Connected Wind Power System
Authors: Chaou Youssef , Ziani Said , Achour Hafid Ben , Daoudia Abdelkarim , El Hassouani Youssef
Published: April 2024

The contribution of this paper is to study a nonlinear control approach known as the backstepping control method to manage reactive and active power using new parametric values for the grid connected wind power generation system. Specifically, the research focuses on a system containing a wind turbine system, a permanent magnet synchronous generator (PMSG), and a grid connected via AC/DC/AC converter. A comprehensive mathematical model for both the wind turbine system, PMSG, and the grid connected via AC/DC/AC converter was developed for this purpose. The Simulation results of the grid-connected wind power generation system are presented and analyzed to show the performance of the nonlinear backstepping control method. The characteristics of the response to variations in generator speed and the power injected into the grid show the highlight of the performance of the backstepping method, under varying wind conditions.
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives
Authors: Dai Cong , Huang Yu-Hong , Jiang Min
Published: April 2024

In this editorial we comment on the article published in the recent issue of the World journal of Gastroenterology . We focus specifically on the mechanisms un-derlying the effects of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS), the factors which affect the outcomes of FMT in IBS patients, and challenges. FMT has emerged as a efficacious intervention for clostridium difficile infection and holds promise as a therapeutic modality for IBS. The utilization of FMT in the treatment of IBS has undergone scrutiny in numerous randomized controlled trials, yielding divergent outcomes. The current frontier in this field seeks to elucidate these variations, underscore the existing knowledge gaps that necessitate exploration, and provide a guideline for successful FMT imple-mentation in IBS patients. At the same time, the application of FMT as a treatment for IBS confronts several challenges.
Diseño de un sistema de absorción de energía para el aterrizaje de módulos de exploración espacial
Authors: Estrada-Barbosa Quirino , Martínez-Rayón Eladio , Reynoso-Jardón Elva Lilia , Silva-Aceves Jesús , Nandayapa-Alfaro Manuel de Jesús , Wiebe Lara C. , Enríquez-Aguilera Francisco Javier
Published: April 2024

Actualmente la exploración espacial está convirtiéndose en una actividad cada vez más importante desde que permiten aumentar el conocimiento en cuanto a la formación de planetas, actividades económicas (minería espacial) así como un mejor entendimiento de fenómenos geológicos y biológicos que permitan en el futuro la creación de hábitats humanos fuera del planeta Tierra. En este sentido, uno de los principales problemas de la exploración espacial está asociado al aterrizaje seguro de las sondas espaciales. A partir de lo anterior el presente artículo propone el diseño de un sistema de absorción de energía del tipo pasivo basado en deformación plástica de perfiles estructurales de aluminio. Para tal propósito se diseñaron y evaluaron individualmente perfiles estructurales con diversas formas geométricas utilizando el software de elementos finitos Abaqus. La evaluación numérica se realizó a través de ensayos de compresión en conjunto con el cálculo de los principales parámetros de resistencia al impacto. Los resultados mostraron un mejor desempeño del perfil CH-C el cual obtuvo la mejor eficiencia de fuerza de aplastamiento (CFE) igual a 0.83. A partir de lo anterior se implementó en un modelo discreto de un módulo de aterrizaje.
Las TIC y las TAC en la Enseñanza de las Matemáticas en el Nivel de Básica Primaria Rural y Urbana
Authors: Yovanny Malpica Mario , Estupiñan Estupiñan Omar Julian
Published: April 2024

Las tecnologías y sus herramientas representan un soporte en el proceso educativo y por su índole están relacionadas con las matemáticas como ciencia que impregna todos los ámbitos del conocimiento. El objetivo del artículo es analizar hasta qué punto las producciones científicas exhiben la aplicabilidad de las Tic y las Tac en la enseñanza-aprendizaje de las matemáticas, específicamente en el nivel de básica primaria del medio urbano y rural. Para ello se aplicó la técnica de revisión documental y el Resumen Analítico de Información (RAI) como instrumento de recolección de datos a documentos como artículos, trabajos de investigación e informes oficiales publicados entre 2018 a 2024 en su mayoría referentes al contexto colombiano. La revisión permitió sistematizar y categorizar los alcances y potencialidades, condiciones limitantes y los retos actuales relacionados con nuevos conocimientos acerca del tema. Se concluye con el reconocimiento de la aplicabilidad de las Tic y las Tac por su importancia en la evolución de la educación gracias a novedosos recursos para el proceso de enseñanza en el ámbito urbano y rural, no obstante, las condiciones como capacitación docente y conectividad, constituyen desafíos, donde el acompañamiento y control de las políticas digitales es vital.
Núcleos de Turismo Ecológico como Articulador del Paisaje Urbano Sostenible en Morales–San Antonio
Authors: Leon Ruiz Miguel Mesias , Gil Gonzales Nahún , Vílchez Ramos Estaylor Marcelino , Chafloque Pinedo Luisa Enith
Published: April 2024

La Región de San Martín, forma parte de la selva del Perú, y mantiene condicionantes ecológicas evocados al turismo medioambiental, los cuales abarcan desde recursos naturales hasta los culturales (Dirección Regional de Comercio y Turismo [DIRCETUR], 2019). Los Objetivos identifican núcleos de turismo ecológico, delimitan perímetros y patrones geomorfológicos, interpretan el territorio y su transición a través de las transformaciones del paisaje y reconocen dinámicas turísticas sociales de las personas en la Provincia. Esta investigación tiene como enfoque cualitativo, y los resultados evidencian un eje con potencial turístico en la ciudad de Tarapoto, que va teniendo un crecimiento urbanístico muy acelerado (Arévalo & León, 2017), en el que se aprecia lugares ecológicos urbanizados. Por tanto, al no ser identificadas para su desarrollo como núcleo de turismo, el paisaje amazónico experimenta alteraciones dentro y en la periferia del casco urbano, causando perdida de cobertura vegetal.
Escala Regional y Microregional en Ecuador: Contribuciones Teóricas hacia la Sostenibilidad Territorial
Authors: Mendieta Orellana Mónica Elisabeth , Sánchez Loja Wilson Fernando , Abad Mendieta Eduarda
Published: April 2024

La insuficiencia de coordinación, cooperación y vínculos para la sostenibilidad territorial ha motivado la búsqueda de alternativas a los procesos regionales, los cuales han mostrado desequilibrios en el fomento del desarrollo, principalmente en áreas pequeñas o históricamente excluidas. No obstante, en Ecuador, la regionalización resurgió en ámbitos políticos y académicos tras la Constitución de 2008, otorgando un estatus político-administrativo al concepto de región. El objetivo de este artículo es exponer las contribuciones teóricas en torno a la “región y la regionalización”, destacando la experiencia ecuatoriana, a partir de la revisión y análisis documental, en el marco de una investigación cualitativa de carácter crítico interpretativa. Se delinea el concepto de “región” como unidad elemental de planificación, se examina la trayectoria de la regionalización en Ecuador y se expone la noción de microrregión como una opción al desarrollo subregional, con el fin de promover la vida territorial sostenible en estas áreas.