bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience with Transcordal Silicone Stents in Adult Laryngotracheal Stenosis: A Bicentric Retrospective Study
Authors: Bourinet Valerian , Raguin Thibaut , Fortin Marc , Chetrit Elsa , Guinde Julien , Laroumagne Sophie , Fakhry Nicolas , Astoul Philippe , Debry Christian , Dutau Hervé
Published: April 2018

Background: Benign stenosis involving laryngeal and upper tracheal structures represents a therapeutic challenge. Open surgery and endoscopic management have to be discussed by a multidisciplinary board in order to evaluate the risk and benefit for each patient. Objective: The objective of this retrospective study was to report the experience of two French centers with transcordal silicone stents (TSS) in the endoscopic management of benign laryngotracheal stenosis (BLTS) in adults, with focus on efficacy, safety, and tolerability. Methods: We performed a retrospective chart review of all cases of BLTS treated with TSS between January 2001 and June 2017 at two tertiary centers in France: the Centre Hospitalier Régional Universitaire de Strasbourg and the Hôpital Nord de Marseille. Results: A total of 17 patients were included. Eleven had a tracheostomy at initial management which consisted of 8 T-tubes and 9 strictly endoluminal stents placements. The main complications were minor aspirations in 5 patients (29%), granulation in 3 patients (18%), migration in 2 patients (12%), and severe dysphonia in 3 patients (18%). After a mean duration of 18.3 months, 11 patients (65%) had had their TSS definitely removed, 13 patients were tracheostomy free (76%), and a TSS remained in place in 4 patients (24%). Conclusions: Adult BLTS treatment with TSS placement is associated with low morbidity and excellent clinical outcomes, with a large proportion of patients free of airway instrumentation on long-term follow-up.
Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches
Authors: Lee Chisong , Eom Younghyon Andrew , Yang Huisuk , Jang Mingyu , Jung Sang Uk , Park Ye Oak , Lee Si Eun , Jung Hyungil
Published: April 2018

Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 µm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.
Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders
Authors: Toshchakova Valentina A. , Bakhtiari Yalda , Kulikov Alexander V. , Gusev Sergey I. , Trofimova Marina V. , Fedorenko Olga Yu. , Mikhalitskaya Ekaterina V. , Popova Nina K. , Bokhan Nikolay A. , Hovens Johannes E. , Loonen Anton J.M. , Wilffert Bob , Ivanova Svetlana A.
Published: April 2018

Background: Human aggression is a heterogeneous behavior with biological, psychological, and social backgrounds. As the biological mechanisms that regulate aggression are components of both reward-seeking and adversity-fleeing behavior, these phenomena are difficult to disentangle into separate neurochemical processes. Nevertheless, evidence exists linking some forms of aggression to aberrant serotonergic neurotransmission. We determined possible associations between 6 serotonergic neurotransmission-related gene variants and severe criminal offenses. Methods: Male Russian prisoners who were convicted for murder (n = 117) or theft (n = 77) were genotyped for variants of the serotonin transporter (5HTTLPR), tryptophan hydroxylase, tryptophan-2,3-dioxygenase, or type 2C (5-HT2C) receptor genes and compared with general-population male controls (n = 161). Prisoners were psychologically phenotyped using the Buss-Durkee Hostility Inventory and the Beck Depression Inventory. Results: No differences were found between murderers and thieves either concerning genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior. Conclusions: The lack of biological differences between the 2 groups of prisoners indicates that the studied 5HT-related genes do not differentiate between the types of crimes committed.
Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials
Authors: Chan Christopher T. , Kaysen George A. , Beck Gerald J. , Li Minwei , Lo Joan , Rocco Michael V. , Kliger Alan S. ,   the FHN Trials
Published: April 2018

Background: Regression of left ventricular hypertrophy (LVH) is feasible with more frequent hemodialysis (HD). We aimed to ascertain pathways associated with regression of left ventricular mass (LVM) in patients enrolled in the Frequent HD Network (FHN) trials. Methods: This was a post hoc observational cohort study. We hypothesized LVH regression with frequent HD was associated with a different cardiovascular biomarker profile. Regressors were defined as patients who achieved a reduction of more than 10% in LVM at 12 months. Progressors were defined as patients who had a minimum of 10% increase in LVM at 12 months. Results: Among 332 randomized patients, 243 had biomarker data available. Of these, 121 patients did not progress or regress, 77 were regressors, and 45 were progressors. Mean LVM change differed between regressors and progressors by –65.6 (–74.0 to –57.2) g, p < 0.001. Regressors had a median (interquartile range) increase in dialysis frequency (from 3.0 [3.0–3.0] to 4.9 [3–5.7] per week, p = 0.001) and reductions in pre-dialysis systolic (from 149.0 [136.0–162.0] to 136.0 [123.0–152.0] mm Hg, p < 0.001) and diastolic (from 83.0 [71.0–91.0] to 76.0 [68.0–84.0] mm Hg, p < 0.001) blood pressures. Klotho levels increased in regressors versus progressors (76.9 [10.5–143.3] pg/mL, p = 0.024). Tissue inhibitors of metalloproteinase (TIMP)-2 levels fell in regressors compared to progressors (–7,853 [–14,653 to –1,052] pg/mL, p = 0.024). TIMP-1 and log (brain natriuretic ­peptide [BNP]) levels also tended to fall in regressors. Changes in LVM correlated inversely with changes in klotho (r = –0.24, p = 0.014). ­Conclusions: Markers of collagen turnover and changes in klotho levels are potential novel pathways associated with regression of LVH in the dialysis population, which will require further prospective validation.
Mifepristone Inhibits the Migration of Cervical Cancer Cells by Inhibiting Exocrine Secretion
Authors: Sang Lin , Wang Xiaoyan , Zhao Xingbo
Published: April 2018

Cervical cancer (CC) is one of the most common gynecological malignancies, and metastasis limits the use of surgical resection. Metapristone (MIF) was reported to suppress the proliferation and migration of several cancer cells. Exosomes play a variety of roles in cellular biological processes. The relation of exosomes and CC is less studied. Cell viability, apoptosis assay and migration assay was conducted in HeLa cells treated by MIF by CCK-8 kit, staining by Annexin V-fluorescein isothiocyanate and propidium iodide, and wound test respectively. ISG15 expression level was examined in MIF-treated HeLa cells by Western blot. The migration of HeLa cells treated by MIF/GW4869 was measured by wound test. MIF suppressed the growth and migration, as well as induced apoptosis of CC cells. MIF inhibited the exocrine secretion of CC cells by upregulating ISG15, while treating CC cells by ISG15 stimulus, IFN, inhibited the secretion of exosomes. The inhibition of exocrine secretion by GW4869 enhanced the migration inhibition of MIF on CC cells. This study demonstrates that MIF suppresses the CC cell migration by inhibiting exocrine secretion through upregulating ISG1.
Urinoir Model as A Liquid Organic Fertilizer Producer of Nitrogen, Phospate and Potassium
Authors: Ganefati Sri Puji , Sutomo Adi Heru , Iswanto Iswanto
Published: April 2018

Environment plays role as transmission media for various kinds of environmental based diseases such as Acute Respiratory Infection (ARI), Pulmonary Tuberculosis, Diarrhoea, Poliomyelitis, Measles, Hepatitis, Thypus and Herpes. This kind of disease stills a health problem for Indonesia. The mortality survey conducted in ten provinces by Sub-Directorate of ARI of the MoH of Indonesia in 2005 found that Pneumoniae as a type of ARI diseases was the greatest cause of death among infants (22.3 %) and under-five children (23.6 %), and based on Surkesnas report in 2010, the number of Thypus cases in Indonesia increased by 20.73 %. Meanwhile, among those diseases, Thypus, Hepatitis and Herpes can be transmitted by human urine, as well. On the other hand, urine can be processed becoming organic fertilizer because it consists of essential substances for plants growth, i.e. 80 % Nitrogen and Phospate and Potassium in the rest 20 %. 75 – 90 % of the Nitrogen is in form of Urea and only the small percentage of Ammonium and Creatinine. Meanwhile, 90 – 100 % of Phosphate and Sulphur   are in dissolved inorganic form and can be directly absorbed by plants. The use of liquid organic fertilizer is able for improving soil fertility which is depraved due to the continuing use of chemical fertilizer. The aim of the research was to understand the influence of the use of urinoir model in various urine detention times, on the concentration of the yielded Nitrogen, Phospate and Potassium (K) by conducting an experiment which employed post-test design. The results showed that the various urinoir models (I, II dan III) had effect on the concentration of those three substances of the liquid fertilizer (p < 0,001), and Model I (i.e. 5 day detention time) is found as the most appropriate urinoir model in producing the N, P an K subtances in the fertilizer.
Immunomodulatory Effects of Papain in Patients with Cervical Ectopies
Authors: Musakhodjeva Dilorom Abdullaevna , Yuldashev Marufjon Abidovich , Nuraliev Neqqadam Abdullaevich , Sabitova Rano Turdievna , Yangieva Gulnara , Fayzullaeva Nigora Yakhayevna
Published: April 2018

The study detected that in patients with cervical ectopia production of cytokines (TNFα, IL-4 и IL-10) was significantly altered. The degree of changedepended on the presence or absence of infection. Conducted therapy withherbal enzyme - papain contributed to the cupping of inflammation andnormalization of the concentration of the studied cytokines.
Student’s Perception and Attitudes toward Public Health Profession and National Competency Examination
Authors: Munira Lafi , Handayani Lina
Published: April 2018

  Normal 0     false false false  EN-US X-NONE X-NONE
 One form of quality assurance is convening public health’s national competencies examination in academic phase which is conducted before students graduate from university. The purpose of this study was to determine students’s perceptions and attitudes about public health’s profession and national competencies examination. The design of this study was descriptive qualitative employed case study approach. Focus group discussion was used to collect data. Data were analyzed by content analysis. Students felt less confident about their identity profession so that requires motivation by lecturer. Students expressed the need to improve public health graduates’s competencies since academic phase. National competencies examination is important to do as a solution to guarantee the graduates’s quality. Implementation of the competencies test is need to consider aspects of management and technical readiness.  National competencies examination is a tool that could proves the identity of public health graduates’s competencies. Everyone with a public health background should know that there will be a competency test then they should have an adequate preparation.
Do Males and Females Differ in Terms of Their KAP Regarding Halal Pharmaceuticals?
Authors: Sadeeqa Saleha , Sarriff Azmi
Published: April 2018

There is an increasing awareness amongst Muslim consumers to avoid all items containing  non-Halal ingredients including medications. Male and female are different both biologically and psychologically, it therefore, needed for a study to compare KAP of males and females regarding  Halal pharmaceuticals. Methods:This was a cross-sectional study using a structured , self-administered questionnaires to compare the knowledge, attitude & perception regarding Halal pharmaceuticals, among males and females in Penang state of Malaysia. Results revealed that there is no significance difference in the knowledge, attitude and perception of males and females. This is concluded that males and females are equally aware and have same attitude and perception regarding Halal pharmaceuticals. P value of .05 or less was taken as statistically significant.
Factors associated with Institutional delivery in Boricha district of Sidama zone, southern Ethiopia
Authors: Gudura Tafese Tadele , Debiso Alemu Tamiso , Gudura Tariku Tadele
Published: April 2018

Every year, 40 million women give birth at home without the help of a
skilled birth attendant. In 2011, 287,000 women died during pregnancy or childbirth. Almost all these deaths occur in developing countries where mothers and children lack access to basic health care. Reports showed the low utilization of health facility for delivery service in Ethiopia. This study aimed to determine the utilization and factors influencing institutional delivery. Community based cross sectional study was conducted from January to February 2013/14 in Boricha District of Southern Ethiopia among mothers who gave birth in the last 1 year. Multistage sampling techniques were used to collect data from 546 mothers. Taking in to account place of birth for the last child, only 4.9% women gave birth in a health facility. Women’s education level (AOR=4.4 (95% CI=1.36-14.33)), timing of firstANC visit (AOR= .03 (95% CI=0.004 - 0.205)), women’s advice to deliver in a health facility during ANC (AOR = 31.15 (95% CI=2.02-479.52)), women’s knowledge of birth related complications (AOR= 12.4 (95% CI=2.67-57.16)) and decision making power (AOR=0.2 (95% CI=0.060.82)) showed significant association with institutionional delivery. Institutional delivery in the study area was found to be very low. Raising awareness on institutional delivery to maximize delivery service utilization and strengthening provision of education and counseling to deliver in health facility during antenatal care visits at individual and community level should be given due emphasis.
Biosecurity of Poultry Worker Related to Avian Influenza in Bangladesh
Authors: Roy Swapan Kumar , Hossain Quazi Zahangir
Published: April 2018

Research on biosecurity of poultry workers of Live Bird Market (LBM) in urban and rural areas related to highly pathogenic avian influenza (AI) was undertaken during March-June, 2014 at Keshabpur upazila (22°48´-22°57´N latitude and 89°06´-89°22´E longitude), Jessore, Bangladesh. A non-randomized (purposive) sampling method was applied and a descriptive type of cross sectional study was performed among 72 workers, dividing them into two groups as 36 urban and 36 rural poultry workers of LBM through split-halves variation technique. They were interviewed confidentially in their work place using a structured pretested questionnaire. Among respondents 53%, 75%, 45%, 81%, and 56% of urban and 50%, 42%, 50%, 89%, and 36% of rural residence had attended up to primary school, knowledge about AI through media like TV and radio, used proper personal protective equipment as mask and gloves, washed their hands and equipment after finishing work and cleaned stalls/cages daily and mostly they used water as a cleaning material, respectively. In urban (14%) and rural (36%) workers used the same vehicle to transport poultry and humans. A combined effort is required to enhance knowledge and change behavior among those most at risk in low-income countries and precautions necessary to avoid spreading the virus among poultry and humans.
Malaria Disease Distribution in Sudan Using Time Series ARIMA Model
Authors: Musa Mohammed Ibrahim
Published: April 2018

Malaria is widely spread and distributed in the tropical and subtropical regions of the world. Sudan is a sub-Saharan African country that is highly affected by malaria with 7.5 million cases and 35,000 deaths every year. The auto-regressive integrated moving average (ARIMA) model was used to predict the spread of malaria in the Sudan. The ARIMA model used malaria cases from 2006 to 2011 as a training set, and data from 2012 as a testing set, and created the best model fitted to forecast the malaria cases in Sudan for years 2013 and 2014. The ARIMAX model was carried out to examine the relationship between malaria cases and climate factors with diagnostics of previous malaria cases using the least Bayesian Information Criteria (BIC) values. The results indicated that there were four different models, the ARIMA model of the average for the overall states is (1,0,1)(0,1,1)12. The ARIMAX model showed that there is a significant variation between the states in Sudan.
The Efficacy of The Integrated Child Development Services in Perspective to Nutritional Condition and Growth Development
Authors: Joseph Jemy Elizabeth , Mathew Shiju
Published: April 2018

A survey was conducted to assess the nutritional status of children (0-6 years) among 40 Anganwadis in 4 districts of Kerala State registered under the ICDS scheme. A self- prepared structured interview schedule was used. To get the qualitative information of the study anthropometric measures include height and weight were used for assessing nutritional status of the children. The stepwise analysis of two variables height for age and weight for age was applicable on the basis of Waterlow’s and Gomez’ classification. To examine the relationship between nutritional status of the child and selected variable that affects nutritional status of children, Chi-square test was employed. Based on Gomez’ classification, out of 400 children, only 300 (75.0%) of children received supplementary nutrition through ICDS out of which 250 (62.5%) children were normal while 50 (12.5%) were underweight. Based on Waterlow’s classification out of 400 children, only 290 (72.5%) of children received supplementary nutrition through ICDS out of these children 200 (50 %) were normal while 90 (22.5%) were stunted. It can thus be concluded that majority of children were normal who received supplementary nutrition through ICDS.
Role of Mothers’ Nutritional Knowledge, Nutritional Factors on The School Performance
Authors: Farhana JasminAra , Akther Farhana , Talukder Mesbah Uddin , Islam Md. Ariful , Islam Md. Torikul , Bhuyan Md. Aminul Haque
Published: April 2018

A cross sectional study was carried out to investigate the effects of mothers’ nutritional knowledge, health and nutritional factors and socio-economic parameters on school performance among class five students of University Laboratory School, Dhaka. All of the eighty students were selected for this study. This study found there is a strong relationship between mother’s knowledge score and school performance. It was found that mothers’ knowledge score was responsible for 91.1 percent change in school performance. The mean BMI of the mothers was 20.44. We found that the school performance measured by class roll number of the students is significantly related with mothers BMI. There was an imperfect negative association between socio-economic parameters and school performance. But the relationship between the school performances with socio-economic parameters was strongly significant. This study also observed the relationship between Individual Dietary Diversity Score (IDDS) of respondent and marks achieved in class 4 final exam. It is alarming that consumption percentage were low for eggs (30) and milk and milk products (37.5), but majority of the students who consumed milk and milk products (63.3%) and eggs (66.7%) got the highest marks.
Antioxidant Activity of Some Selected East Borneo Plants
Authors: Ahmad Islamudin , Sulistiarini Risky , Rijai Laode
Published: April 2018

The native plants of East Borneo the Costus specious (Koening) J.E. Smith stem, Lagerstroema spesiosa Pers leaf, Cerbera mangans L leaf, Vitis trifolia L fruit., Scurrula atropurpurea (Blume) Danser root, Brucea javanica (L.) Merr. leaf, Lygodium microphyllum, Bidens Chinensis Willd., Sonneratia caseolaris L. peel, Sonneratia caseolaris L. stem is almost under-explored for their potensial benefits. They were extracted by the solvents of increasing polarity (n-hexane, ethyl acetate, and n-butanol) were tested for their free radical activity against DPPH (2,2-diphenyl-1-picrylhydrazyl). The ethyl acetate extract of Costus spesiosus (Koening) J. E. Smith antioxidant were screnned concentration of 68 ppm, similarly athyl acetate extract of Vitis trivolia L., showed antioxidant activity at 64,30 ppm. As the ethyl acetate extract of Scurrulla atropurpurea (Blume), Brucea javanica (L.) Merr, Lygodium microphyllum and Sonneratia caseolaris L. stem, showed antioxidant activity at 273,52 ppm, 91,12 ppm, 17,39 ppm and 7,03 ppm. N-butanol extract of Lagerstroema spesiosa Pers, Cerbera mangans L, Bidens chinensis Willd, and Sonneratia caseolaris L. peel showed 8,37 ppm, 128,59 ppm, 18,17 ppm and 54,29 ppm antioxidant activity using DPPH model systems. Owing to the property, the studies can be further extended to exploit them for their possible application for preservation of food products as well as their use as health supplements.
Independency Models of Nursing self-care for Ischemic Stroke Patient
Authors: Mendrofa Fery Agusman Motuho , Wahyuni Chatarina U. , Nursalam Nursalam , Machfoed Hasan , Kuntoro Kuntoro , Notobroto Hari Basuki , Hargono Rachmad , Widjonarko Bagus
Published: April 2018

Stroke injury such as physical and psychological disorders was required assistance such as the community, nursing professional and family. Family and social factors play an important role in independence strokes such as support family members provide encouragement for self care.The objective of aim the study wasto assess indicator of self care and model family support related self care. A cross-sectional survey research design was used. Data was collected with interviews by home visited method. Data were analyzed with confirmatory analysis for determined of validity and reliability indicator, models analyzed by SEM (Structural Equation Model).Family support such as information, instrumental, reward and emotion were valid indicator for family support. Self care indicators such as eat, bath, titivate, dress, defecating, urination and transfer to building of self-care. Indicators of eating, bathing, titivate, dress, defecate, urination, and transfer is an indicator for self care. It could be concluded that eating, bathing, ornate, dress, and the transfer is valid and reliable. Model showed that self-care needs were improved of self-carepatients with through family support.
Sexual Self-schema, Perceptions of Breast Talk, and Physical Self-concept in Breast Cancer Survivor
Authors: Abraham Juneman , Puteri Miranti Ayu
Published: April 2018

The quality life of breast cancer survivors has been the psychology’s focus of attention. However, studies discussing their sexuality highlighted from the social psychology perspective are still not very much, especially in Indonesia. This study aimed to predict sexual self-schema of breast cancer survivors based on their perceptions of the breast talk and physical self-concept. This study used a predictive-correlational design and employed psychological scales measuring instruments, multiple linear regression data analysis technique as well as purposive sampling method. This study was conducted on 130 women breast cancer survivors (Mage = 39.45 years old; SDage = 3.542 years; all been married) in Special Capital Region of Jakarta - the capital city of Indonesia, and its surrounding areas (Bogor, Tangerang, and Bekasi). The study results showed that the perception of functional breast talk and physical self-concept are able to predict sexual self-schema in positive directions. Other perceptions of breast talk (medicalized, gendered, and sexualized breast talk) are not able to predict it. This study has important implications in order to improve the life quality of the survivors, namely by managing fair discourses about breast in the public and keeping the proper physical self-concept since the early stage of life.
Patient Safety Applications for Improving Health Care Quality
Authors: Rosyidah Rosyidah , Jatmika Septian Emma Dwi
Published: April 2018

Patient safety is the fundamental thing that needs to be taken care of by medical staff when giving healthcare to patient  especially in the Emergency Installation. PKU Muhammadiyah Public Hospital at Bantul has implemented Patient safety well in providing services for patients. Expected to be a reference for other hospitals to implement Patient safety as well as efforts to improve the quality of health services, but do not close the possibility there were still some deficiencies that could be made a suggestion for the PKU Muhammadiyah Bantul Hospital. There for researchers interested to review more detail how application of Patient safetyin Emergency Installation PKU Muhammadiyah Bantul Public Hospital in 2014. This research was qualitative observational study, using research subjects: The Head of the medical service, 1 Officer of Emergency Installation, the head of disaster management, 1 medical doctor, 1 nurse, and 4 patients that were taken with inclusion criteria: getting inpatient class III Hospitals in Yogyakarta, have inpatient  more than 1 day. All the input items on the application of patient safety which include facilities, equipment, drugs, procedures, and activities of officers at Emergency Installation at PKU Muhammadiyah Bantul Hospital, as well as the application process is in compliance with the Guidelines of Observation Guidelines Patient Safety 2008 Survey and Guidelines for Accreditation of Hospital Emergency Services Specific Guidelines (revised edition 2007), ACT No. 44 Hospital in 2009, and patient safety procedures 2008. Patient perceived output includes five dimensions of quality (Tangible, Reliable, Responsiveness, Assurance and Empathy) all have the same perception of good and satisfying. Application on standard input, process and output is suit with Observation Guidelines for Patient Safety 2008 Survey and Guidelines for Accreditation of Hospital Emergency Services Specific Guidelines (revised edition 2007), ACT No. 44 Hospital in 2009, and patient safety procedures 2008.
Obesity and Hypertension in Students of Jahangirnagar University: Alarming Issues
Authors: Paul Sudip , Solayman Md. , Biswas Puja , Saha Moumoni , Hossain Md. Sabir
Published: April 2018

The prevalence of obesity and hypertension (HTN) in university students of Bangladesh has not reported yet. Considering the proper health maintenance of this population in mind, the study was aimed to determine the prevalence of obesity and HTN as well as relationship among them in the students of a residential university of Bangladesh, Jahangirnagar University. This descriptive cross sectional study included 500 randomly selected students (250 males and 250 females). Participants completed a questionnaire on physical activity, sedentary behaviour, dietary factors, smoking and family history of obesity, HTN, and coronary artery disease. Blood pressure and anthropometric parameters such as height, weight, waist and hip circumferences were measured following standard procedure. The Statistical analyses were performed using the software SPSS.The prevalence of overweight was 25% (31.1% males, 15.6% females) and obesity 7.2% (9.4% males, 4% females). Pre-HTN was found at 27.1% (38% males, 11.2% females) and HTN at 2.2% (3.3% males, 0.4% females). A high rate of smoking, sedentary behavior, physical inactivity, excessive consumption of unhealthy food, and caffeine-rich drinks was also observed. Significant correlation was found between parameters of obesity and HTN. High prevalence of pre-HTN in males and central obesity in females were found which is immediately needed to control for better health maintenance of this population.
Incidence of Opportunistic Infections among Adult HIV Positive People Receiving Co-trimoxazole Prophylaxis
Authors: G Yihun Tariku , Yaya Yaliso , Jerene Degu , Tamiso Alemu
Published: April 2018

In Ethiopia, Co-trimoxazole prophylaxis therapy (CPT) used to prevent opportunistic infections among people living with HIV is the standard of practice; however incidence of opportunistic infection and their predictors are rarely documented in the country.  This was a retrospective follow up study to describe the incidence and predictors of opportunistic infections among 244 adults receiving CPT. Participants were followed for a median time of 72 weeks. During a study period a total of 53opportunistic infections were recorded; making the overall incidence rate 23.9/100 person-years. High incidence of opportunistic infections is likely to occur if: the clients were married (adjusted hazard ratio (AHR) 1.965;(95% CI: 1.109, 3.451), had history of tuberculosis treatment (AHR: 2.34(95% CI:1.05, 5.24)), patients who are indicated for CPT because of both clinical and WHO clinical staging criteria(AHR 2.418 (95% CI:1.02, 5.72 ),and had poor adherence to CPT (AHR, 2.11 (95% CI: 1.19-3.72)). Eventhough adherence is non-substitutable strategy to prevent opportunistic infection, the cohort of HIV patients failed to adhere to CPT, which in turn resulthigh incidence of opportunistic infections among them, therefore improving adherence as guideline should be a priority to prevent OIs among people living with HIV in the study region.
Model to Reduce HIV Related Stigma among Indonesian Nurses
Authors: Sismulyanto Sismulyanto , Supriyanto S. , Nursalam Nursalam
Published: April 2018

Stigmatization of persons living with HIV (PLWH) did by health professionals including nurses. Stigma was a barrier of nurses to implement nursing care to PLWH patients. The purpose of this study was to make model of reducing stigma among nurses particularly in the hospital, district of Banyuwangi, Indonesia. Design used in this study was analytical observational. The population was all nurses who worked in 4 hospitals in Banyuwangi of Indonesia. Total sample recruited were 77 respondents. Data were collected by questionnaire and analyzed by using Smart PLS (Partial Least Squares). The result showed that stigma existed among nurses particularly on labelling and stereotyping to PLWH patient. Transcultural components had influence to nurses’ stigma on HIV and AIDS patients; there were jobs factor, facilities factor, values factor, and knowledge factor. Stigmatizing attitudes were found among nurses with quite satisfied. It can be concluded to reduce the stigma of nurses by intervening on transcultural components among other factors affecting jobs factor, facilities factor, values factor and knowledge factor. Further research should apply this model in nursing care.
Vascular Endothelial Growth Factor Concentration in Brain of Rat Treated with Anaerobic Exercises
Authors: Flora Rostika , Zulkarnain Muhammad , Ardi Yuliana , Sorena Esti , Wati Roslina , Wena Syokuma , Juliansyah Rahmad Aswin , Slamet Samwilson
Published: April 2018

Anaerobic  exercise is a high-intensity exercise that needs quick energy supplies obtained in a very short time. However, this exercise may result in tissue hypoxia which is characterized by the increase of HIF-1α concentration. The presence of HIF-1α will induce the secretion of VEGF and, eventually, trigger angiogenesis. Nevertheless, it is still unclear whether anaerobic exercise will also cause hypoxia in which this condition will increase the concentration of VEGF in brain tissues. The aim of this study was to find out the effect of anaerobic exercise frequency towards VEGF concentration of Wistar rat brain tissues.  Brain tissues were taken from rats treated with anaerobic exercise using treadmill. This exercise was given in different frequencies; one time, three times, and seven times a week.  The data collected were analyzed using independent t-test. The results of this study showed that anaerobic  exercise done once a week could significantly increase VEGF concentration (p < 0.05) if compared with the one in control group (95.21 ± 31.99 v.s. 63.36 ± 11.01 pg/mL). Meanwhile, VEGF concentration of treatment groups given exercise three times a week (47.97 ± 10.68 pg/mL) and seven times a week (40.56 ± 13.98 pg/mL) showed a significant decrease if compared with that of control group (63.36 ± 11.01 pg/mL). Anaerobic  exercise affected VEGF concentration as an indicator of angiogenesis in brain tissue of wistar rats.
Gabapentin and Amitriptilin Treatment toward Living Quality of Post Ischemic Stroke Patients with Neurophaty Pain
Authors: Utami Pinasti , Ikawati Zulies , Setyaningsih Setyaningsih
Published: April 2018

Stroke becomes a significant problem for developing countries. In Indonesia the data show its incidences 234 per 100.000 people, and around 2 - 8 % stroke patients experiencing cerebrovascular session will get neurophaty pain. It happens because of sensoric deviation after stroke, so the brain does not completely send information to the body correctly. Patients experiencing neurophaty pain are able to face decreasing living quality as the effect of long term painful disturbance. Therefore, it is important to maintain the patients’ living quality. The aim of the study is to investigate the comparison of using gabapentin and amitriptilin toward living quality of ischemic stroke patients with neurophaty pain in the hospitals in Jogja. The method used in this study was quasi experimental with consequtive sampling. The study was conducted on 22nd of April-31st of Juli 2013 by involving 23 patients in gabapentin group and 18 patientsin amitriptilin group that would be evaluated during 1 month. Living quality was assessed by Brief Pain Inventory (BPI) in week 0 and week 4. The result of the study showed that the use of gabapentin and amitriptilin in 4 weeks showed the increase of living quality represented by decreasing the score based on BPI questioner 1.67±0.78 and 1.37±0.80 with p-value>0.05 meaning that there was no significant difference. It can be concluded the comparison of using gabapentin and amitriptilin in post ischemic stroke patient with neuropathy pain not significantly increase the quality of in the hospitals in Jogja.
A Case Report of Marfan Syndrome with Literature Review
Authors: Kumar Kalla Hemanth , Kumari Swarna , Rama rao CH , Parthasarathy MKR , Reddy S Surya prakash , Revathi M
Published: April 2018

Marfan syndrome(MFS) is a connective tissue disorder that affects multiple organ systems. Cardiovascular, ocular, and skeletal abnormalities are cardinal features of the syndrome. Its incidence is among the highest of any heritable disorder.Most patients who have Marfan syndrome are usually diagnosed incidentally when they present for a routine physical examination for various reasons. The purpose of this paper is to provide a review of the literature, as well as describe a 22-year-old male with MFS and right hydroureteronephrosis diagnosed incidentally when he attended our hospital for complaints of fever and right loin pain. This case report emphasizes importance of “Revised Ghent criteria” for the diagnosis of MFS and highlights various clinical signs of MFS.
Double Burden of Malnutrition among Undergraduates in Ogun State Nigeria
Authors: Oladoyinbo Catherine Adebukola , Ekerette Nkereuwem N
Published: April 2018

Coexistence of under and over nutrition among the same population group is referred to as the double burden of malnutrition. The objective of this study was to assess double burden of malnutrition among undergraduate students in Ogun State Nigeria. A cross-sectional study involving 1,115 (37.8%) males and 1,835 (62.2%) females was conducted.  Body mass index (BMI) was derived from weight and a height measurement, waist circumference (WC) measurement was taken to assess abdominal obesity. SPSS version 16 was used for data analysis. Mean age, height, weight and BMI were 23±0.05years, 1.63±0.001m, 60.99±0.22kg and 22.80±0.08kgm respectively. Mean WC was 82.21±0.32cm and 80.55±0.49cm among males and females respectively. Based on BMI, the Prevalence of underweight, overweight and obesity were 13.4%, 16.9% and 7.5% respectively. BMI did not relate significantly with both age (p=0.464) and gender (P=0.115). About fifty percent (50.64%) of females and 12.36% males who were overweight and obese also had excess abdominal fat. Prevalence of abdominal obesity was significantly higher among females (16.9%) than males (2.5%), (p=0.001). Respondents in this study were faced with problems of both under-nutrition and over-nutrition.
Knowledge and Behaviour about Adolescent Reproductive Health in Yogyakarta, Indonesia
Authors: Solikhah Solikhah , Nurdjannah Sitti
Published: April 2018

Lack of knowledge about reproductive health in adolescent, making teens easily influenced by misinformation and harmful to their reproductive health. Health education plays an important role in increasing their knowledge and behavior of young people in order to maintain good reproductive health.  The purpose of the research was to see the impact of health education on the knowledge and behavior of adolescents in reproductive health. Paired t test analysis results indicate that counseling on reproductive health effect on both knowledge about reproductive health (mean difference: 10.216, 95% CI: 6.622 to 13.809) and attitudes about reproductive health in adolescents (mean difference: 65.417, 95% CI: 11,176 to 61.690). Knowledge of adolescents about reproductive health would be beneficial in preparing the young people in good reproductive health issues so expect teenagers do not conflict with the norms prevailing in the community.
Magnitude of Out of Pocket Health Expenditures and Associated Factors among Civil Servants
Authors: Geremew Mekuanenet , Gedefaw Molla , Tsegay Girmay , Kassa Getachew Mullu
Published: April 2018

In Ethiopia, as other developing countries, public health care is provided at nominally low prices and free to those that does not afford to pay. But the health care consumer population is still to make considerable amount of out-of-pocket health expenditure for various reasons. A cross sectional quantitative study from January to May 2013 was done. Study population was civil servants in Debre Markos town. A total of 467 study participants were selected by using simple random sampling method. Data were collected by trained high school graduates and then the collected data were entered into a computer by using Epi-Data version 3.1 and analysis was performed by using SPSS version 16 for windows. Possible associations between out of pocket health expenditure and its predictors were analyzed by using both bivariate and multivariate analysis. The mean age of the study participants were 41 years. Majorities were between 25 and 44 years of age, 258 (55.2%). The level of education among the study participants indicated that most 380 (81.4%) were graduates of higher education (HE) and majority were Orthodox Christian which accounted 446 (95.5%) followed by Muslims 13 (2.8%). To put it briefly, the study identified that the median of out of pocket health care expenditure accounted 8.26% of total household income. Health status of the household (with or without chronic illness), debt on any of the household, house on construction owned by any household member, educational fee for at least one member of the household and predominantly used health institution were the associated factors that have significant impact on household out of pocket health expenditure. There is economic burden as a result of health care at household level.   Based on the results, the recommendation was introducing social health insurance for all civil servant employees in the study area.
The Difference of Satisfaction Level in BPJS Health Insurance Patient and Non Insurance Patient toward Health Service
Authors: Dewi Arlina , Ramadhan Naufal Kurnia
Published: April 2018

National Health Insurance (JKN) developed in Indonesia is part of the National Social Insurance System (SJSN). One way to assess the services quality is to measure the patient satisfaction level. This research is a quantitative research with the cross sectional research design. The subjects of this research were the BPJS health insurance patients and non insurance patients with 200 people as the samples. The data was analyzed by the independent t-test, gap analysis, CSI (Customer satisfation index) and IPA (Importance performance analysis). The result showed that significant (ρ value >0,05) in all dimensions which mean that there is no difference of patient satisfaction level in Social Security Organizing Body (BPJS)  participants and non insurance patients toward health services in Negara General Hospital. The biggest satisfaction in non insurance patients is on the Assurance variable (-1,002) and the smallest satisfaction is on the Tangibles variable (-1,357) and the biggest satisfaction of BPJS health insurance patients is on Assurance variable (-1,085) and their smallest satisfaction is on Responsiveness variable (-1,367). The non insurance patients gap is (-0,217) and the BPJS health insurance patients gap is (-1,206), both of them were classified into low satisfaction level. The result of Importance performance analysis value of non insurance patient showed Responsiveness attributes that should be prioritized and improved while in BPJS health patients showed Responsiveness and Reliability attributes that should be prioritized and improved by Negara General Hospital.
Recycling Waste of Rice Husk to Improve Entrepreneurship Motivation
Authors: Tentama Fatwa , Asti Mulasari Surahma , Maulana Muchsin , Anggraeni Rini
Published: April 2018

The farmers in Indonesia have not maximally taken advantage of the existence of rice husk; therefore the huge number of the husk becomes disturbing waste, which spoils environment. The waste of rice husk is potentially capable of improving the farmers’ economy amidst the people’s lack of knowledge about its potential to commercially produce charcoal briquettes from it, make it a plant growing medium, and change it into manure. This research aims at knowing if the training of recycling waste of rice husk can improve the farmers’ entrepreneurship motivation. The subjects of the research were farmers in groups at Bimomartani village, Ngemplak district, Sleman regency. They were 60 participants divided into experintal and control groups. The planned experiment used untreated control group design with dependent pretest and posttest samples. The paired sample t-test and independent sample t-test were used as the techniques of analysis in this research. The result of t-test on paired sample t-test for the experimental group resulted in the value of t = -6.659 with p = 0.000 (p<0.01), which means there was a significant difference of entrepreneurship motivation before and after the training of recycling rice husk. The analysis for Independent sample t-test resulted in the value of t = 7.411 with p = 0.000 (p<0.01), which means there was a significant difference of entrepreneurship motivation between experimental and control groups. It can be concluded that the training of recycling waste of rice husk was effective in improving the farmers’ entrepreneurship motivation.
Accuration of Fine Needle Aspiration Biopsy in Musculoskeletal Tumour
Authors: Magetsari Rahadyan , Marseno Hengkie , Lanodiyu Zikrina , Dewo Punto
Published: April 2018

Fine needle aspiration biopsy (FNAB) has been reported to be the preferable choice of biopsy for musculoskeletal tumour. While FNAB appears to have advantages to core biopsy in the aspect of simplicity and cost, the diagnostic accuracy should be the most critical parameter in determining the choice of biopsy. This research was designed to evaluate the diagnostic accuracy of fine needle aspiration in musculoskeletal tumour in Sardjito Hospital from 2010 until 2014. This was a descriptive study from medical record in Sardjito Hospital from 2010 until 2014. The inclusion criteria are musculoskeletal tumours in all age level that has been performed FNAB with subsequent operative treatment and confirmation of histopathology examination in Sardjito Hospital. There were 41 elligible subjects in this study. Concordance diagnosis of FNAB and histopathological examination in all musculoskeletal tumor cases was found to be 86%. In addition, the concordance in soft tissue tumor cases was 94% with the detail as follows: giant cell tumor was 86%, synovial sarcoma was 50% and liposarcoma was 50%. In bone tumours, the accuracy was found to be 60% with the detail as follows: distribute osteosarcoma was 60%, osteochondroma was 50% and chondrosarcoma was 50%. Our data showed that accuracy of FNAB for diagnosis of musculoskeletal tumours was 86% with soft tissue tumour 94%, bone tumour 60% and others 93%. Therefore, Fine needle aspiration biopsy is still important diagnosis tool in musculoskeletal tumours.
Model of Empowerment to Improve Autonomy Directly Observed Treatment (DOT) Tuberculosis Patients
Authors: Khariroh Syamilatul , Soedirham Oedojo , Hamidah Hamidah , Abdullah Endang
Published: April 2018

Empowerment as not yet optimal health promotion efforts done to enhance the autonomy of Directly Observed Treatment (DOT), which affect the success of the recovery of patients with pulmonary tuberculosis. The purpose of research was to develop a model empowerment based on Health Promotion and Health Literacy with approach to nursing intervention in an effort  enhance the autonomy of the DOT - pulmonary TB patients. The method was an observational analytic with cross sectional approach. Multistage random sampling was DOT-pulmonary TB patients to decide the district and simple random sampling was assigned to choose the participants, a total of 253 DOT- pulmonary TB patients new case with acid resistant bacilli positive on the advanced phase in this study. The study conducted in five districts in Surabaya City (center, north, south, east and west). Data were collected by questionnaire on variables namely personal, cognitive and affective, nursing intervention, commitment, family supports, health literacy and DOT- autonomy. Structural Equation Modeling (SEM) with LISREL is used for constructing predictive model. Result : This study found a new model which was developed based on combination of Health Promotion Model (HPM) and Health Literacy (HL). Statistical result confirm that personal, cognitive and affective, health literacy and family support considered as important factors in improving DOT-autonomy. Conclusion : DOT- autonomy will improve by considering four main factors, personal, cognitive and affective, health literacy, family support. This model can be adapted by District Health Office Surabaya City as the main actor regional health development. In addition, this model may become a reference for other district in improving their nursing intervention in community setting.