bluuebunny/crossref_metadata_2025 huggingface dataset:
The ICOM International Committee for Literary and Composers’ Museums as the preservation tool of World Documentary Heritage
Authors:   The Leo Tolstoy National Museum-Estate “Yasnaya Polyana”, Alekseeva Galina V.
Published: January 2025

The article introduces the readers to the activities of one of the oldest ICOM international committees (International Council of Museums), dealing with the heritage of literary and composers’ museums — International Committee for Literary and Composers’ Museums (ICLCM). Founded in 1977, at the ICOM General Conference held in Moscow and Leningrad, the committee has been involved in all the spheres of the museum life typical for literary and composers’ museums. The committee numbers over 300 members from 45 countries. Every year the committee holds its annual conferences in various countries, for example, the Conference in 2015, where D. P. Bak presented the project of Encyclopedia “Literary Museums of Russia”, created by the State Museum of the History of Russian Literature named after V. I. Dahl and the Association of Literary Museums. ICLCM publishes the annual Book of Proceedings. The Committee is very active in collaboration with the UNESCO Programme of the World Documentary Heritage (Memory of the World) and in 2017, celebrated the 25th anniversary of the UNESCO programme during the sessions of 12th International Seminar of Translators of Tolstoy and other classical writers at Yasnaya Polyana, with the UNESCO participation. The seminar, organized as a museum-congregation with ICLCM, is traditionally held at the base of L. N. Tolstoy’s personal library, it is an important tool in storing documentation.
Regional and national aspects of the state of the network of literary museums in Russia
Authors:   Vladimir Dahl State Museum of the History of Russian Literature, Korneeva Anastasiia A.
Published: January 2025

The results of the author’s work of this research on a block of articles about the regions and
a summary article about the network of literary museums in Russia for the encyclopedia
“Literary Museums of Russia” are considered. The process of preparing this publication has
been conducted since 2014 by the Vladimir Dahl State Museum of the History of Russian
Literature in collaboration with the Association of Literary Museums and with the support
of the Ministry of Culture of the Russian Federation. As a result, two volumes of the encyclopedia
were published in 2022 and 2024. The publication is devoted to literary museums,
one of the most important for profile groups in Russia. The main blocks of articles, the
structure of articles about the regions are described, and the information contained in them
is indicated. The need to distinguish between literary museums and objects that partially
perform museum functions, such as museum-type institutions was noted. The concept of
the article about the network of literary museums in Russia is described, statistical data on
their number in the constituent entities of the country where there is a network of museums
of this profile group, taking into account all possible forms of owner (state, municipal,
departmental, public, private) is represented in the context of time perspective (2016, 2022,
2023). The obtained results are compared, the most developed regional are identified, the
factors influencing the increase or decrease of the presented indicators areidentified. The
general collection of museums of this profile group in the Russian Federation in all variety
of their types and kinds is shown. The regions where are museums of national literature,
national writers, and thehistory of Russian literature are designated. Possible use of the
obtained data is proposed.
Observers of the Russian Orthodox Church at the Second Vatican Council
Authors:   Department for External Church Relations of the Moscow Patriarchate, Zvonarev Archpriest Sergiy
Published: January 2025

The purpose of the article is a comprehensive based on sources and researches presentation of one of the brightest and most intense pages of relations between the Russian Orthodox Church and the Roman Catholic Church in the second half of the 20th century — the presence of Church observers from Moscow at the Second Vatican Council. Russian and foreign scientists have attempted to find out the reasons that prompted the authorities of the Russian Church to change its initially restrained attitude towards the prospects of its representatives’ presence at the Council of the Catholic Church, to link the decision to accept the invitation from the Catholic side with the policy of the Soviet Union towards the Vatican. The assessments and conclusions of most researchers indicate that there is a relationship between the decision of the authorities of the Moscow Patriarchate to send observers to Rome and the political interests of the USSR. However, this external aspect of the issue highlights its inner side, namely the interests of the Church, consistently promoted by Metropolitan Nikodim (Rotov) in his activities in the Catholic direction. Although Church and state interests differed from each other, they were intertwined at the same time. Cultivating a relationship by the Moscow Patriarchate and the Soviet Union with the Vatican had different goals: for the Church it meant overcoming internal isolation and strengthening international authority, and for the USSR it was an attempt to involve the Vatican in a peaceful movement, reduce the degree of its anti–Soviet attitude and acquire a partner in the camp of Western countries. At the same time, the promotion of the Vatican’s interests on Soviet territory, primarily an attempt to solve the problem of the situation of the Uniates, met solidary opposition from both the authorities of the Soviet Union and of the Russian Church, making them allies. The topic of delegating observers of the Moscow Patriarchate to the Second Vatican Council was one of the few topics that met the interests of all parties — the Russian Church, the Soviet Union and the Vatican.
The fall of angels as the cause of death of animals in theistic evolutionism
Authors: Dementyev Leonid I.
Published: January 2025

According to the Book of Genesis, man acquired a mortal body as a result of the fall of Adam and Eve, but the Bible leaves open the question of the origin of suffering and death of animals. Since natural evil does not correspond to God’s omnipotence, theologians have put forward several explanations for its appearance. First of all, alterism, which claims that there was another universe, and natural evil arose because of its concealment or destruction. The second interpretation is classical the istic evolutionism, which considers natural evil to be an inevitable side effect of creation. There is also a lesser — known point of view, according to which the cause of suffering and death is the rebellion of angels. Although the Book of Genesis does not explicitly speak about the intervention of angels in creation, the prerequisites for such a view are found in later biblical and patristic texts. The New Testament points to the relationship between the angelic and our world, and in the view of some saints, God controls the universe through intermediaries. If such intermediaries rebelled, their downfall could lead to pathological ignorance of the world soul and earthly souls about God’s plan and the appearance of weak bodies that do not provide control over the passive states. Adam and Eve inherited this weakness and returned to their former state after the fall. To explain why the Lord has not yet corrected the natural evil, the author puts forward the concept of irreversible damage to the world and the need for its gradual improvement. At the end, answers to any objections that may arise are also given.
Christological and triadological foundations of the musical idea in the theological aesthetics of Hans Urs von Balthazar
Authors:   Historical Park “Russia — my History”, Zakhryapin Alexander A. , Semikopov Daniil V. ,   Historical Park “Russia — my History”,   Nizhny Novgorod State Pedagogical University named after Kozma Minin
Published: January 2025

The article is devoted to the consideration of the Christological and triadological foundations of the musical idea in the theological aesthetics of Hans Urs von Balthazar. The Christological criterion is reduced to the principle of “analogia eventus pulchri et Christi” (“analogy of the event of beauty and the event of Christ”). Music is designed to serve as a finger pointing to Christ and to bear witness to Him as God and Savior of the world. Then a meeting with music will be a meeting with God. In the three-part structure of music (rhythm, melody, harmony) H. U. von Balthazar sees a manifestation of the highest trinitarian beauty, based on the principle of inter-apostolic communion of the Most Holy Trinity. Nevertheless, music, being a “translator of information of the Divine”, only opens the veil of the trinitarian mystery, without communicating in its entirety the whole idea of God. Rhythm as the ontological basis of the universe and the primary human experience of the Divine principle symbolizes God the Father in H. U. von Balthazar. Melody as the noblest element of music, emerging from formless darkness, and taking shape in the light of day — the Logos and the mystery of God Incarnation. Harmony as a structure-forming function, the basis of music, giving it its logical conclusion reveals the mystery of the Holy Spirit, Who, like a great orchestra conductor, leads the life of the Church.
Heroism and holiness in the aspect of Orthodox theology
Authors:   V. I. Vernadsky Crimean Federal University, Shevchenko Oleg K. , Podlesnaia Mariia A. ,   Institute of Sociology Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences
Published: January 2025

In the article, the authors formulate three universal postulates of the connection between the heroic and the sacred, characteristic of any European culture from Antiquity to the present day: “A hero is always a sufferer”; “A hero is always a tragic figure”; “A hero is a figure separated or separated from society, policy, family, history, common sense”. In Christianity (as in Hellas, Ancient Rome or Islam), these three postulates acquire their semantic texture. Heroism is comprehended as nothing more than determination and readiness for personal suffering for the sake of an allgood goal overshadowed by God’s will. A voluntary decision, or rather a compulsion of oneself to daily cooperation with God’s will with the awareness of the tragic result of one’s personal earthly existence. Heroism is rather a willingness and a state of compelling oneself to do. But holiness comprehends suffering, gives it deep content and consolation, which is higher than the worldly sadness of separation from society or the usual way of life. Postulates, hypotheses and intermediate conclusions are tested on the empirical material of the All-Russian survey conducted in 2023 (eight federal districts of the Russian Federation, 1350 respondents). Particular attention is paid to the answers of two categories of respondents: practicing (551) and nonpracticing (638) believers.
“There is always an unchangeable core in the icon, expressing the theological and dogmatic meaning of the image…”
Authors:   St. Andrew’s biblical theological institute, Yazykova Irina K.
Published: January 2025

In a conversation with art critic and theologian Irina Yazykova, fundamental and topical issues of iconology are discussed. An icon is defined as a sacred and prayerful image expressing the conciliar experience of the Church and created in accordance with certain rules (iconographic canon). The differences between the canonical icon and religious painting are considered, including with such examples of the latter, which are functionally icons, but no longer fit into the iconographic canon. Examples of “incorrect icons”, the historical conditions of their appearance and the corresponding church reactions are analyzed. Russian icon discovery at the beginning of the 20th century, the role of the Russian post-revolutionary emigration in the promotion of the Orthodox icon and the development of icon painting, the efforts of art historians and restorers of the Soviet period in the preservation and study of the Russian icon are briefly described. Attention is also paid to what is called the theology of the icon, indicating the main works in this area. The topic of the perception of the icon, primarily Russian, in the Western Christian context is touched upon. The contribution of the Russian emigrant icon painter Grigory Krug is assessed. The question of whether icon painting is an art or a craft is highlighted; the nature of the revival of icon painting in the post–Soviet period is also assessed. Examples of achievements in the field of icon painting in the present period are given, indicating the authors. The relationship between icon painting and religious art as part of the so-called contemporary art in general is also discussed. At the end of the conversation, we are talking about the prospects of the icon as an expression of the unchanging experience of the Church.
Sociologia, sociólogos e campo político uma aproximação sociológica ao caso português
Authors: Machado Fernando Luís
Published: January 2025

This article takes a sociological approach to the relationship between sociology and sociologists and the political field in Portugal. It focuses in particular on two dimensions of this relationship: sociology applied to public policies and the participation of sociologists in the political class. In the final section, it suggests an agenda for further sociological research not only on these two dimensions, but also on the relationship between sociologists and social movements and on the contribution of sociology to the consolidation of democratic political values.
Exortação à guerra (pela sociologia portuguesa)
Authors: Silva Augusto Santos
Published: January 2025

The institutionalisation of sociology in Portugal took place within the framework of democracy. This helps to understand the traits that mark and singularise Portuguese sociology, such as pluralism, diversity, multilingualism and interdisciplinarity. All of these have allowed the discipline to develop very quickly, intensively and inclusively. But today we face a threat: the subordination to the purely quantitative and bureaucratic logic of the rules for recruiting and promoting teachers and researchers, funding projects and publishing scientific texts. This logic can destroy the freedom and diversity that are so characteristic of Portuguese sociology. It is therefore essential to combat it.
Cement nélküli totál térdprotézisekkel szerzett rövid távú tapasztalataink klinikánkon
Authors: Antal Hunor , Than Péter
Published: January 2025

Tekintettel arra, hogy egyre fiatalabb életkorban kerülnek beültetésre térdízületi endoprotézisek, ezekrevíziójára egyre gyakrabban van szükség. A cement nélküli totál térdprotézisek célja a tartósság és afunkció növelése, és a hosszabb élettartam elérése. Bár a cementes rögzítés esetén is jók a klinikai eredmények,ezeknél a fiatalabb betegeknél a hosszabb protézis túlélés különösen fontos kérdés. A szerzők24, cement nélküli totál térdprotézis beültetésével szerzett tapasztalataikról számolnak be. 8 férfit és13 nőt operáltak, 3 esetben végeztek (eltérő időpontban) mindkét oldali protézisbeültetést. Az átlagosutánkövetési idő 2,25 év volt (12–63 hónap). A Knee Society Score (KSS) átlaga a preoperatív 56,34-ről aműtét után 84,18-ra nőtt, az átlagos mozgástartomány 103,2°-ról 120,4°-ra nőtt. A radiológiai utánkövetéssorán aszeptikus lazulást nem találtak és szeptikus szövődmény sem volt. Mind a KSS, a radiológiai és aklinikai eredmények, mind a szubjektív megítélés alapján az eredmények kiválóak voltak. A cement nélkülitotál térdprotézisek a fiatal betegek térd endoprotetikája során fontos alternatívát képviselnek.
Carboxymethyl holocellulose as alternative carbohydrate-based binder for biomass briquette development
Authors: Ilham Dewantoro Awaly , Fauzan Muklis , Adly Rahandi Lubis Muhammad , Nurliasari Desy , Mardawati Efri
Published: January 2025

The use of starch as a binder in biomass briquette production raises concerns regarding food security, prompting the need for alternative, non-food-based binders. This study aimed to develop carboxymethyl holocellulose (CMH) derived from oil palm empty fruit bunches (OPEFBs) as a sustainable and effective binder for biomass briquettes made from coconut shells and sawdust. The OPEFBs were converted into CMH through a carboxymethylation process, yielding a product with a carboxyl content of 12.81% and a degree of substitution (DS) of 0.40, indicating effective modification. The synthesized CMH was used as a binder at various concentrations, with citric acid (CA) employed as a crosslinking agent. The total carboxyl content significantly increased with higher CA concentrations, demonstrating improved functional properties. Briquettes produced using CMH exhibited favorable proximate characteristics, such as low moisture content, high fixed carbon, and enhanced calorific value, particularly for coconut shell-based briquettes. The findings suggest that CMH can serve as an alternative to starch, providing sustainable and environmentally friendly solutions for biomass briquette production. Future studies should focus on optimizing the synthesis process and exploring CMHs’ performance in diverse biomass formulations.
Does social media marketing enhance brand loyalty? identifying mediators relevant to local fast food industries
Authors: Yuswita Effy , Maulidah Silvana
Published: January 2025

The increasing growth of businesses has intensified competition within various industries, particularly in the local fast food sector. One effective marketing strategy that can be employed is social media marketing. Consequently, it is essential to conduct research to analyze the impact of perceived social media marketing activities on brand loyalty, with brand awareness serving as an intervening variable. The objective of this study was to examine the influence of perceived social media marketing activities on enhancing brand loyalty. This research was conducted among consumers of local fast food in the Malang Raya region, utilizing convenience sampling techniques. The analysis was performed using SEM-PLS 7.0. The findings indicate that social media marketing activities have a positive and significant effect on local brand awareness and local brand loyalty. However, local brand awareness does not significantly mediate local brand loyalty. Electronic word of mouth (E-WOM) effectively mediates the connection between social media marketing and brand loyalty. In contrast, nationality did not effectively moderate the influence of social media marketing, brand awareness, and electronic word of mouth on brand loyalty. Thus, in the current era, massive social media activity within the local fast food industries can positively impact brand loyalty.
Effect of variations in drying temperature of papaya seeds (Carica papaya L.) on the physiochemical characteristics of jelly candy
Authors: Aldhianto Utomo Rizki , Nurindra Rahmadhia Safinta
Published: January 2025

Papaya seeds contain various phenolic compounds, such as flavonoids, which act as antioxidants. However, papaya seeds have a tart taste and pungent odor caused by benzyl isothiocyanate compounds. The drying process of papaya seeds can reduce the tartness and fragrant odor of papaya seeds. This study aimed to evaluate of different drying temperatures on the physicochemical and organoleptic characteristics of jelly candy made from papaya seeds.. This study used three drying temperatures: 50 °C (F1), 60 °C (F2), and 70 °C (F3). After drying, the papaya seeds are powdered and processed into jelly candy. Jelly candy was prepared by adding jelly powder and gelatin to achieve the desired texture. The physicochemical analysis included measurements of water content, ash content, pH, antioxidants, flavonoids, and texture, while organoleptic evaluations assessed sensory properties. Statistical analysis was performed using one-way ANOVA. The results showed no significant decrease in water content (14.59%–15.58%), while pH (4.7–4.9), antioxidant activity (4.44%–24.03%), and total flavonoid content (4.31–8.09 mgQE/g) decreased. Ash content significantly increased (0.37%–0.40%). The physical properties analysis showed hardness values of 133.17–151.89 N, gumminess of 33.03–51.70 N, and chewiness of 21.07–36.44 N. Organoleptic analysis revealed that panelists most favored sample F3.
Effect of eHealth Interventions on Body Image of Patients With Cancer: Systematic Review (Preprint)
Authors: Huang Guohong , Wu Rongrong , Xu Xiuzhi , Song Yongxia , Zheng Rong , Chen Xi , Hong Jingfang
Published: January 2025

BACKGROUND

Body image issues are prevalent among individuals diagnosed with cancer, leading to detrimental effects on their physical and psychological recovery. eHealth has emerged as a promising approach for enhancing the body image of patients with cancer.

OBJECTIVE

The purpose of this study was to evaluate the effectiveness of eHealth interventions on body image and other health outcomes (quality of life, physical symptoms, and emotional distress) among patients with cancer. In addition, the acceptability, engagement, and challenges of eHealth interventions were also assessed.

METHODS

A total of 11 databases were searched, encompassing PubMed; Embase; Web of Science; MEDLINE (via Ovid); Scopus; the Cochrane Library; CINAHL (via EBSCO); OpenGrey; and 3 prominent Chinese repositories: China National Knowledge Infrastructure, China Wanfang Database, and China VIP Database. The search dates were from the inception of the database to September 25, 2024. The inclusion criteria for this study encompassed research that used randomized controlled trials (RCTs) and quasi-experiments (QEs) to examine the effectiveness of eHealth interventions for patients with cancer. The methodological quality of RCTs and QEs was evaluated using the Cochrane risk of bias tool and the Joanna Briggs Institute Critical Evaluation Checklist, respectively. The review adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was registered with PROSPERO.

RESULTS

There were 3548 studies reviewed, and 7 studies were selected. Three studies were RCTs and 4 were QEs, involving a total of 512 patients. Evidence of efficacy for eHealth interventions targeting body image and other health outcomes (physical symptoms and emotional distress) was mixed. Nevertheless, our findings indicate that there was no notable enhancement in quality of life resulting from eHealth interventions. A total of 5/7 (71%) studies reported the acceptability of eHealth interventions among patients with cancer, and patients perceived eHealth interventions as acceptable. However, the difficulty of operating the software, determination of the most effective course of treatment, and time constraints emerged as the primary challenges associated with electronic interventions.

CONCLUSIONS

The implementation of eHealth interventions has the potential to enhance body image, physical symptoms, and emotional distress in patients with cancer. Researchers should undertake more rigorous experiments in the future to elucidate the effectiveness of eHealth and address pertinent concerns.
A Scoping Review: Exploring the Role of Serious Game for Combating Postnatal Depression in New Parents (Preprint)
Authors: Wang Weijie , Penney Erika , Gay Valerie , Garcia Jaime
Published: January 2025

UNSTRUCTURED

Perinatal mental health issue are now recognised as a significant public health concern all over the world. The global prevalence of Postnatal Depression (PND) was found to be approximately 17.22%. Current reviews lack focus on digital interventions targeting parents in late pregnancy or postnatal stages, instead centering on other populations with depression. Few address how gamified interventions can promote help-seeking behaviors for PND. Existing studies prioritize symptom relief over fostering help-seeking behaviors. Therefore, this study aims at identifying what serious games have been applied to support the treatment of PND and what gaps are still left to explore. As a result of this search and filter process, 13 works were completely reviewed, analyzed and categorized in this paper. In the reviewed papers the games found include serious games, casual video game, game-based learning program, gamification apps and commercial games. Implications of these finding for the application of serious games to PND will be discussed.
ETHOSOMES CARRYING ETODOLAC-EFFECTIVE DRUG CARRIER AS TOPICAL DOSAGE FORM IN THE TREATMENT OF RHEUMATOID ARTHRITIS
Authors: BACHHAV ASHWINI A. , PINGALE PRASHANT L. , UPASANI CHANDRASHEKHAR D.
Published: January 2025

Objective: The priority-based objective of this research was to develop and evaluate the etodolac loaded Ethosomes as topical delivery in Rheumatoid Arthritis autoimmune disease.
Methods: The ethosomes (EE1-EE6) were prepared with varied concentrations (10%-60% v/v) of ethanol by using Rotary evaporator. The prepared Ethosomes evaluated for %EE (Entraptment Efficiency), Zeta potential, SEM (Scanning Electron Microscopy), TEM (Transmission Electron Microscopy), Vesicle size, In vitro release, In vivo study, Irritancy test, stability test etc.
Results: Prepared ethosomes analysed for zeta potential, vesicle size and % entrapment efficiency and ranges are found to be-18.50mV to-64.53mV, 166.66 nm to 848.97 nm and 53.15% to 89.35%, respectively. Furthermore, when these ethosomes were incorporated in Carbopol 940 gels (EEC1-EEC6), it evaluated for appearance, spredability, pH, viscosity study, drug content and In vitro drug release. All ethosomal gels show satisfactory results. After optimization of ethosomes (EE1-EE6) and ethosomal gels (EEC1-EEC6) on previous criteria, optimised formulations EE4 and EEC4 characterised for SEM, TEM, Ex-vivo permeation, Irritancy, In vivo and different analytical evaluation. The values of r2 were found higher for the first-order model and Korsmeyer-Peppas model for all formulations. Irritancy test shows safe use of formulation and in vivo test shows that EEC4 had a significant inhibitory effect on edema, which was developed in the right paw of rat by injecting carrageenan when it compared with plain Carbopol gel and marketed formulation.
Conclusion: The present study has confirmed that the formulated Etodolac Ethosomal gel can be used as best vehicle for topical administration, which may be used for the management of rheumatoid arthritis.
EXPLORING JACKFRUIT FLOUR POLYPHENOLS AS PROMISING SGLT-2 INHIBITORS FOR HYPERGLYCEMIA MANAGEMENT
Authors: PATIL SHASHANK M. , G. MANU , M. RAMYA C. , S. RAJASHEKHARA , DESAI SUDHANVA M. , PARAMESWARAN SARAVANAN , RAMU RAMITH
Published: January 2025

Objective: This study explored the potential of dietary polyphenols from whole green jackfruit flour as natural Sodium-Glucose Co-Transporter-2 (SGLT-2) inhibitors for managing hyperglycemia in diabetes mellitus.
Methods: Advanced bio-computational techniques, including molecular docking, Molecular Dynamics (MD) simulations, and binding free energy calculations, were employed to identify and assess polyphenols from jackfruit flour. Caffeic and syringic acids were highlighted for their strong binding affinities to the SGLT-2 receptor. Additionally, a ligand-based pharmacophore model was developed using caffeic acid as a reference to screen for new lead compounds in commercial and natural product databases.
Results: The study found that caffeic acid and syringic acid exhibited stronger binding affinities and more stable interaction profiles with the SGLT-2 receptor than the standard drug empagliflozin. MD simulations demonstrated that these compounds provided greater stability in the binding site, indicating their potential efficacy as SGLT-2 inhibitors. The pharmacophore screening further supported these findings, identifying both compounds as promising lead candidates.
Among the 14 dietary polyphenols obtained from High-Performance Liquid Chromatography (HPLC), a molecular docking study suggested that caffeic acid (binding affinity:-9.0 kcal/mol) and syringic acid (binding affinity:-9.1 kcal/mol) exhibited stronger binding affinities and more stable interaction profiles with the SGLT-2 receptor compared to the standard drug empagliflozin (binding affinity:-10.4 kcal/mol). Further, molecular dynamics simulations demonstrated that these compounds provided greater stability in the binding site, indicating their potential efficacy as SGLT-2 inhibitors through Root mean Square Deviation (RMSD), Root mean Square Fluctuation (RMSF), Radius of Gyration (Rg), Solvent Accessible Surface Area (SASA), and ligand hydrogen bonds. The pharmacophore screening further supported these findings, identifying both compounds as promising lead candidates.
Conclusion: This study is the first to identify caffeic acid and syringic acid from whole green jackfruit flour as effective SGLT-2 inhibitors. These natural compounds show significant potential as novel agents for managing hyperglycemia and diabetes mellitus. The findings support further exploration of plant-derived therapies in diabetes treatment.
SILK FIBROIN-COATED MESOPOROUS SILICA NANOPARTICLES ENHANCE 6-THIOGUANINE DELIVERY AND CYTOTOXICITY IN BREAST CANCER CELLS
Authors: KABOLI MOHAMMAD AMIN , HASHIM ALAA A. , ALTEMEMY DHIYA , SAFFARI-CHALESHTORI JAVAD , REZAEE MEHDI , HOSSEINI SAYEDEH AZIMEH , KHOSRAVIAN PEGAH
Published: January 2025

Objective: Breast cancer stands as the most prevalent form of cancer among women globally. Conventional chemotherapy, including the use of 6-Thioguanine (TG), often faces limitations such as poor drug solubility. In this research, we engineered a nanosystem consisting of Mesoporous Silica Nanoparticles (MSNs) loaded with TG and coated with Silk Fibroin (SF) to enhance the pharmacokinetic properties of this drug in targeting the MCF-7 breast cancer cell line.
Methods: In this study, we investigated the cytotoxicity of different formulations through MTT assay. Additionally, we analyze apoptosis and cell cycle phase distribution using flow cytometry. Furthermore, the absorption of MSN nanoparticles by MCF-7 cells was investigated using the fluorescent labeling technique by Dil fluorochrome.
Results: Our results represented the 48 h Half Maximal Inhibitory Concentration (IC50) values of free TG, MSNs loaded with TG (TG@MSNs) and SF-coated MSNs loaded with TG (SF/TG@MSN) were 16.69, 10.96 and 8.01 μM, respectively. Moreover, the percentage of total early and late apoptosis differed among the treatments. Specifically, cells treated with free TG, TG@MSN and SF/TG@MSN exhibited 13.49%, 76.05% and 84.99% apoptosis, respectively. The results also indicated that administering free TG and TG-loaded MSN nanoparticles to MCF-7 cells resulted in cell cycle arrest at the G2/M phase after 48 h of treatment.
Conclusion: Our study demonstrated that the SF/TG@MSN nanosystems effectively increased the cytotoxic effects of TG on the breast cancer cell line.
GREEN SYNTHESIZED ZNO NANOPARTICLES WITH CORDYCEPS MILITARIS FUNGUS EXTRACT FOR THE TREATMENT OF MEMORY IMPAIRMENT IN ALZHIEMER DISEASE
Authors: SAINI KHYATI , SHILPI SATISH , SINGHAL NAVEEN
Published: January 2025

Objective: Preparation of Zinc Oxide (ZnO) Nanoparticles (ZnNPs) by green synthesis process using Cordyceps militaris fungus extract and its assessment for the treatment of Alzheimer’s disease.
Methods: ZnO nanoparticles were synthesized using the green synthesis process with Cordyceps militaris fungus extract. The nanoparticles were characterized using various techniques, including SEM, TEM, XRD, EDAX, and optimization techniques to determine their shape, size, surface properties, and crystallinity.
Result: The results showed that the nanoparticles were spherical with a smooth surface, averaging 37.09 nm in size, and exhibited surface Plasmon Resonance at 300 nm. XRD analysis confirmed their crystalline structure. During synthesis, the suspension changed from dark yellow to colorless with cloudiness, indicating nanoparticle formation. The UV-Visible Spectroscopy revealed a SPR peak at 375 nm. Overall, the characterization confirmed the successful synthesis of zinc nanoparticles with desired properties. This study investigated the protective effects of green-synthesized Zinc nanoparticles on memory impairment in mice. Mice were divided into six groups and treated with various substances followed by sleep deprivation to induce memory impairment. Conclusion: Behavioral tests and biochemical analysis revealed the significantly improved cognitive function, reduced acetyl cholinesterase activity in a dose-dependent manner, comparable to Donepezil. Histopathological analysis confirmed the protective effects of Cordyceps militaris against memory impairment.
ANALYSIS OF VOLUMETRIC REGULATION OF HYDRAULIC PUMPS IN HYDROSTATIC SYSTEMS
Authors: Jovanović Vesna , Janošević Dragoslav , Pavlović Jovan , Petrović Nikola , Lazarević Đorđe
Published: January 2025

The paper presents the results of the conducted researches related to the analysis of the parameters of the drive system, the crawler hydraulic excavator, with hydraulic pumps with collective regulation according to the criterion of constant hydraulic power and the regulator of ideal hyperbolic characteristics. A crawler excavator weighing 16,000 kg with a three-member manipulator with boom, arm and bucket with a volume of 0.6 m3 was tested. The paper discusses the principles of volumetric regulation of hydrostatic systems, which is achieved by changing the specific flow rate of the hydraulic pumps. For pumps with constant specific flow rates, regulation is performed by reducing the flow through the hydraulic motors, which increases the pressure in the pump's delivery line and is controlled by a safety valve. This method, however, can lead to oil heating and energy loss. In contrast, pumps with variable specific flow rates use modular regulators that adjust the pump's characteristics based on system parameters, ensuring efficient operation under varying load conditions. The study's findings indicate that the use of hydraulic pumps with combined power regulation and an ideal hyperbolic characteristic regulator allows for the maintenance of constant hydraulic power even with changing loads. This regulation method ensures efficient use of the engine's power and prevents motor overload, enhancing the overall performance and longevity of the excavator. The research underscores the significance of proper hydraulic pump regulation in achieving optimal machine efficiency and durability.
Consideraciones sobre el programa civilizatorio de la colonización francesa en América del Norte (siglos XVII y XVIII)
Authors: Díaz de la Serna Ignacio
Published: January 2025

En este artículo se contrastan algunas de las estrategias que Francia e Inglaterra siguieron respectivamente en su colonización de América del Norte. Una de las más significativas fue la presión demográfica, la cual provocó que los pueblos autóctonos perdieran sus territorios. Sin embargo, en algunos casos, sobre todo entre los franceses, se reconoció que los nativos tenían derecho legítimo de propiedad. De ese modo, el régimen de paz que instauraron los colonos franceses se fundó en su interés por conocer al Otro. Pero el ejercicio de esa mirada etnográfica practicada por oficiales y misioneros se llevó a cabo con afanes imperialistas. Por último, se analizan algunos aspectos antropológicos del proceso de aculturación de los autóctonos y, a la postre, el fracaso de ese programa alentado por Luis XIV.
Efectos del crimen organizado sobre el desarrollo empresarial en la frontera noreste de México y Texas. Un análisis de percepción social
Authors: Alvarado Lagunas Elías , Rodriguez Medina Oscar , Morales Ramirez Dionicio
Published: January 2025

Este artículo examina la percepción social del crimen organizado y su impacto en la seguridad en cuatro estados mexicanos fronterizos con Texas: Coahuila, Chihuahua, Nuevo León y Tamaulipas. A través del análisis de 11,687 publicaciones en la plataforma digital X (antes Twitter) recopiladas entre agosto de 2023 y abril de 2024, se emplean técnicas de Big Data y Text Mining para desarrollar un índice de percepción geoespacial. El estudio revela una percepción ampliamente negativa del crimen organizado, especialmente en términos de extorsión y violencia, y muestra cómo estas percepciones varían entre las diferentes regiones de la frontera noreste de México y Texas. Además, el análisis identifica patrones de discusión y sentimientos en la conversación digital, proporcionando una comprensión más profunda de los factores socioculturales que influyen en la percepción pública de la seguridad en la región. Los hallazgos contribuyen a la discusión sobre la seguridad transfronteriza y su efecto en la vida cotidiana y los entornos sociales y económicos de las comunidades fronterizas.
Construcción y validación de un instrumento de aptitud clínica en lactancia materna en pregrado
Authors: Martínez-Treviño Denisse Aideé , Cobos-Aguilar Héctor , Suárez-Gómez María
Published: January 2025

Introducción: La aptitud clínica en el amamantamiento no se ha estudiado en pregrado. Actualmente no se cuenta con instrumentos para su medición.
Objetivo: Construir y validar un instrumento para medir la aptitud clínica sobre lactancia materna en estudiantes de medicina.
Método: Se construyó y validó un instrumento con cinco casos clínicos (CC): mastitis (MAST), grietas en pezón (GR), prácticas hospitalarias (PH), rechazo al seno (RS), pobre producción de leche (POB) y cinco indicadores: factores de riesgo (FR), diagnóstico clínico (DC), tratamiento (TR), contraindicaciones de lactancia (CL) y pronóstico (PR). Se usó la técnica Delphi con cinco expertos en dos rondas. Se equilibraron los reactivos, con 17 por CC e indicador y 85 en total. Se determinó la consistencia (Kuder-Richardson) con la aplicación a 30 estudiantes de octavo semestre (EM) y 30 médicos internos de pregrado (MIP). Se usó la U de Mann-Whitney para comparar los dos grupos. Se determinó también el azar en las respuestas.
Resultados: Se obtuvo una consistencia interna global de 0.90 y por indicador de 0.74 (FR), 0.58 (DC), 0.62 (TR), 0.72 (CI), 0.77 (PR). El 43% del grupo MIP se situó en rango bajo y 57% del grupo EM en respuestas al azar. La mediana global más alta se obtuvo en MIP comparados con EM (35 vs. 15, p < 0.01). Se obtuvieron medianas más altas en el grupo MIP para los indicadores FR (p = 0.02), TR (p < 0.01), CL (p = 0.03) y PR (p < 0.01) y cuatro CC: MAST (p < 0.01), PH (p < 0.01), RS (p = 0.03) y POB (p = 0.02).
Conclusiones: Un instrumento válido y consistente muestra una aptitud clínica muy baja en pregrado que parece más alto en MIP. Se ameritan mediciones e intervenciones para evaluar la validez extrínseca.
El paciente estandarizado: desarrollo de habilidades clínicas y de comunicación en estudiantes de medicina
Authors: Mendoza García María Isabel , Marín Campos Yolanda , Rodríguez Guzmán Leoncio Miguel , Torres Hernández Rosa María
Published: January 2025

Introducción: El desarrollo de la tecnología para la enseñanza de la medicina ha favorecido el aprendizaje de las habilidades clínicas mediante la simulación como una técnica didáctica interactiva, con la participación del paciente estandarizado se evita el error en pacientes reales.
Objetivo: Evaluar el uso de los PE como herramienta para el desarrollo de habilidades clínicas y comunicación.
Método: Se realizó un estudio prospectivo, analítico, con enfoque cuantitativo, participaron 21 estudiantes de la facultad de medicina de la Universidad Veracruzana. En una primera fase se entrenó a los PE para la representación de tres casos clínicos. Se aplicó una evaluación teórico-práctica virtual de conocimientos, habilidades clínicas y actitudes, con la presentación de los casos clínicos representados por seis PE experimentados, se organizaron dos circuitos con tres estaciones dinámicas, cada una contó con un profesor evaluador. Para el análisis de los datos se utilizó alfa de Cronbach para determinar la confiabilidad de los instrumentos, ANOVA con prueba de Cochran, y coeficiente de correlación intraclase, con p < 0.05 para significancia estadística.
Resultados: Los alumnos de edad 23 ± 2 años. La evaluación de PEs a los alumnos, con alfa de Cronbach 0.978, p < 0.0001. Evaluación a alumnos con alfa de Cronbach 0.949, coeficiente de correlación con p < 0.0001. Evaluación de alumnos por PEs alfa de Cronbach 0.918, con p < 0.0001. En el ANOVA con la prueba Q de Cochran 199.56, con p < 0.0001.
Conclusiones: Se encontró un alto grado de concordancia entre los evaluadores mediante el análisis de los resultados de los instrumentos que utilizaron para la evaluación de habilidades de comunicación Se identificaron las áreas de oportunidad para el apoyo a los alumnos con relación a los conocimientos.
Implicaciones del modelo estructural en la validación de instrumentos clínicos: Modelo reflectivo vs Modelo formativo
Authors: Cruz-Peralta Agles , Peralta-Pedrero María Luisa , Morales Sánchez Martha Alejandra
Published: January 2025

Antecedentes: Los cuestionarios, escalas, índices y criterios de clasificación se desarrollan y someten a validación, para medir de variables subjetivas de manera estandarizada.
Bases teóricas de los modelos estructurales: Cuando las preguntas de un cuestionario se originan a partir del atributo, corresponde al modelo reflectivo que ha sido ampliamente utilizado en psicometría debido a la naturaleza de las variables de interés. En Ciencias de la Salud las variables de interés son diferentes, cuando las preguntas de los cuestionarios nacen de elementos constitutivos y son independientes entre sí, pertenecen a un modelo formativo.
Implicaciones del modelo estructural en el diseño y validación de instrumentos de medición en salud: Cuando se usa el modelo reflectivo se crean un gran número de preguntas, y su reducción se realizará mediante análisis estadístico. Se debe determinar la fiabilidad de la prueba (consistencia interna) y la validez estructural.
Con el modelo formativo se elabora un número reducido de ítems asegurando la validez de contenido con evidencia científica o, en su defecto, por consenso formal de expertos. Para refinarlos, se utiliza el nivel y la calidad de la evidencia, las características de la población objetivo y el propósito del instrumento, los métodos estadísticos y el juicio del investigador y/o el consenso formal de los expertos. Si existe un estándar de oro se realiza un estudio de pruebas diagnósticas, en caso contrario la validez de constructo.
Diferencias del modelo reflectivo versus formativo en la fase de desarrollo del instrumento: Naturaleza del constructo, cronología del fenómeno, relación entre los indicadores o ítems y el constructo, direccionalidad del vínculo entre indicadores y constructo, número de indicadores identificados, ítems a elaborar y posible método de reducción, impacto teórico de la eliminación de ítems o indicadores sobre la idoneidad de la medición del constructo.
Actitudes/percepciones relacionadas al uso de inteligencia artificial en la atención sanitaria entre estudiantes universitarios
Authors: Salas-García Miguel Amaury
Published: January 2025

Introducción: En el ámbito sanitario, la inteligencia artificial (IA) ha surgido como una fuerza transformadora, capaz de mejorar la precisión diagnóstica, optimizar los tratamientos y agilizar los procesos administrativos. Sin embargo, a pesar de sus beneficios la implementación de la IA en la atención sanitaria enfrenta controversias y desafíos.
Objetivo: Determinar las actitudes y percepciones sobre el uso de IA en la atención sanitaria entre estudiantes universitarios (EU) de ciencias de la salud en Guadalajara, Jalisco.
Método: Se aplicó un formulario en línea entre EU para recabar datos sociodemográficos y un cuestionario de 28 ítems para determinar actitudes y percepciones sobre la IA.
Resultados: Participaron 83 EU, mayoritariamente mujeres y pertenecientes a programas de enfermería, nutrición y psicología. Los sujetos reportaron un uso elevado de la tecnología, así como conocimiento moderado respecto a la IA. Respecto a las actitudes del uso de esta en la atención sanitaria, predominó una posición neutral. Aunque reconocieron los posibles beneficios de la IA, mostraron cautela cuando se trataba de su propio diagnóstico o tratamiento. Adicionalmente, surgieron preocupaciones como el desplazamiento y pérdida de empleo del profesional de la salud (PS), la seguridad de los datos y el deterioro de la relación PS-paciente.
Conclusiones: Las actitudes de los EU hacia la IA en la atención sanitaria reflejan una mezcla de sentimientos positivos y negativos, derivados de inquietudes sociales más amplias sobre la rápida integración de la IA en el sector. Tomar en cuenta estas preocupaciones permitirá reducir la brecha existente entre las percepciones de la IA por parte de los EU y favorecer el uso de esta tecnología para mejorar los resultados de los pacientes.
¿Autonomía en riesgo? Ética y la dependencia de la inteligencia artificial generativa en la formación médica
Authors: Sánchez Mendiola Melchor
Published: January 2025

Estamos en el año 2025, a poco más de dos años del debut en el escenario global de una de las herramientas más populares de inteligencia artificial generativa (IAGen), ChatGPT de la empresa OpenAI. La irrupción de esta poderosa plataforma, además de otras diseñadas por diversas organizaciones, ha generado una gran cantidad de especulaciones y reflexiones sobre sus implicaciones éticas en varios aspectos de la vida, incluyendo la educación. Si bien la explosión de artículos, libros, preprints, conferencias, congresos y seminarios web sobre el tema ha producido un cierto nivel de hastío en la comunidad académica, no podemos eludir el hecho de que la IAGen llegó para quedarse y que se ha introducido en muchas facetas de nuestra cotidianidad. Por ello es necesario continuar la conversación sobre su uso e implicaciones para el proceso educativo en profesiones de la salud
Obstacle arrangements effect on the mixed convection in an enclosure with movable top surface
Authors: Shaker A. M. , Yasin N. J. , Ameen H. A. , Abedalh A. S.
Published: January 2025

The flow finds extensive application in coating, drying, and mixing processes. The temperature and velocity distribution inside a rectangular enclosure that is driven by a lid were examined using a finite volume numerical method. Five adiabatic cylindrical obstacles were mounted within the cage measures 25 cm in width and 30 cm in length. The right and left walls enclosure is each fully insulated, the top wall was cooled isothermally at Tc and moved at variable speed of U, and the bottom wall was kept at Th using water as a working fluid. Three types of an obstacle with equal area were utilized in this study they were, circle triangle and square. The results showed that the average Nusselt number increases by 10.4%,12%, 16%, and 19% compared with that of without the obstacle for radius values (r=0.5,1,1.5 and 2 cm) respectively. The results indicate that obstacles can be very useful in achieving a higher rate of heat transfer compared to the enclosure without obstacles. Also, as opposed to a situation without barriers, the results demonstrate that the existence of obstructions causes an increase in the average Nusselt number. When compared to triangular and square shapes, the obstacle with a circular shape has a larger average Nusselt number. Furthermore, the enhancement percentage of Nusselt number was calculated to be 16, 13, 11 % for obstacle models of circle have a radius of 1 cm, triangle and square of 1 cm (major dimension) respectively comparing with that of no obstacles.