bluuebunny/crossref_metadata_2025 huggingface dataset:
MENDIDIK PRIBADI BERKARAKTER “UWA HAENG WULANG, LANGKAS HAENG NTALA”
Authors: Lon Yohanes Servatius
Published: October 2023

AbstractThis article is a socio-cultural comparative study on character education in general and the philosophy and local wisdom within the culture of Manggarai-NTT people that is  “uwa haeng wulang, langkas haeng ntala” (grow up to the moon, and be high up to the sky). For the Manggaraian people, character education should be done optimally (maximally) in order to obtain highest achievement. The expectation is completed with strong personality as described in the phrase “wake caler ngger wa, saung bembang ngger eta” (be rooted in the deepest earth, and reach the outward world). By the comparison, character education in Indonesia will be easily implemented in local context. Moreover, the dialog between the two values will enrich the picture of character education in Indonesian.AbstrakArtikel ini merupakan suatu kajian sosio-budaya perbandingan antara konsep pendidikan karakter pada umumnya dengan filosofi dan kearifan lokal orang Manggarai yakni “uwa haeng wulang, langkas haeng ntala” (bertumbuh sampai ke bulan, tinggi sampai ke langit). Bagi orang Manggarai, pendidikan karakter tidak boleh dilakukan setengah-setengah atau sekadarnya saja. Pendidikan harus dibuat secara optimal agar tercapai cita-cita yang tinggi. Cita-cita itu dilengkapi dengan jati diri yang kokoh seperti dilukiskan dengan “wake caler ngger wa, saung bembang ngger eta” (pribadi yang berakar kuat/ke dalam dan berwawasan luas/ke luar). Melalui perbandingan ini, pendidikan karakter yang dicita-citakan oleh negara Indonesia lebih mudah dilaksanakan di dalam konteks lokal. Lebih dari itu, dialog keduanya dapat saling memperkaya wajah pendidikan karakter di Indonesia. Pengutipan: Lon, Y. S. (2016). Mendidik Pribadi Berkarakter “Uwa Haeng Wulang, Langkas Haeng Ntala”. SOSIO DIDAKTIKA: Social Science Education Journal, 3(2), 2016, 166-174. doi:10.15408/sd.v3i2.4387.Permalink/DOI: http://dx.doi.org/10.15408/sd.v3i2.4387
PROFIL KOMITMEN RELIGIUS DAN IMPLIKASINYA BAGI PENDIDIKAN
Authors: Aisyah Ade , Rohaniawati Dede , Gustini Neng
Published: October 2023

AbstractThis study aims to determine differences in religious commitment and Teaching Faculty of SMA and MA (Pesantren) background, and its implications for learning. This research approach is quantitative descriptive and comparative techniques using questionnaires, the study documentation, and observation. The research data were analyzed using descriptive statistical analysis techniques and inferential. Research hypothesis testing using the comparative analysis is the t-score. The results showed that: there were significant differences of religious commitment among students of Faculty of SMA and MA (Pesantren) backgrounds. Obtained value t = -6.588 with df = 66 and p-value (2 sides / 2-tailed) = 0,000 so it can be concluded that the average score in the student questionnaire with SMA background, is smaller than MA (Pesantren) background. The results showed that there were differences in the profile dimensions religus commitment. First, the lack of communal dimension in the educational backgrounds of students MA (Pesantren). Second, high communal dimension in the educational backgrounds of students in SMA. Third, the dimensions of the experience both equally lacking. Fourth, the dimensions of both beliefs are equally high.AbstrakPenelitian ini bertujuan untuk mengetahui perbedaan komitmen religius mahasiswa Fakultas Tarbiyah dan Keguruan yang berlatar belakang pendidikan SMA dan MA (Pesantren), serta implikasinya dalam pembelajaran. Pendekatan penelitian ini adalah kuantitatif dengan metode deskriptif dan teknik komparatif dengan menggunakan instrumen angket, studi dokumentasi, dan observasi. Data penelitian yang terkumpul dianalisis dengan menggunakan teknik analisis statistik deskriptif dan inferensial. Pengujian hipotesis penelitian menggunakan analisis komparasi yaitu t-score. Hasil penelitian menunjukkan bahwa: ada perbedaan yang signifikan tentang komitmen religius antara mahasiswa Fakultas Tarbiyah dan Keguruan yang berlatar belakang pendidikan SMA dan MA (Pesantren). Didapat nilai t=-6,588 dengan dk=66 dan p-value (2 sisi/2-tailed)=0,000 sehingga dapat disimpulkan bahwa rata-rata skor angket di mahasiswa Fakultas Tarbiyah dan Keguruan yang berlatar belakang pendidikan SMA lebih kecil daripada MA. Hasil penelitian menunjukkan bahwa terdapat perbedaan profil dalam dimensi-dimensi komitmen religus. Pertama, kurangnya dimensi komunal pada mahasiswa yang berlatar belakang pendidikan  MA (Pesantren). Kedua, tingginya dimensi komunal pada mahasiswa yang berlatar belakang pendidikan SMA. Ketiga, pada dimensi pengalaman keduanya sama-sama kurang. Keempat, pada dimensi keyakinan keduanya sama-sama tinggi. Pengutipan: Aisyah, A., Rohaniawati, D., Gustini, N. (2016). Profil Komitmen Religius dan Implikasinya Bagi Pendidikan. SOSIO DIDAKTIKA: Social Science Education Journal, 3(2), 2016, 175-183. doi:10.15408/sd.v3i2.4392.Permalink/DOI: http://dx.doi.org/10.15408/sd.v3i2.4392
PENGARUH KECERDASAN EMOSIONAL DAN MODAL SOSIAL TERHADAP KEMANDIRIAN BELAJAR SISWA DALAM PEMBELAJARAN IPS
Authors: Dianah Lili
Published: October 2023

The study aims to measure and analyze the influence of emotional intelligence and social capital towards self-regulated learning. This study used a quantitative approach and survey method. The samples are 400 students from 16 Junior High Schools grade 8th in West Bandung regency. The research used stratified random sampling. The results showed that emotional intelligence and social capital positive and significant impact on student’ self regulated learning. The influence of emotional intelligence was 0,447, or 20% toward self regulated learning, while the remaining (80%) was influenced by other factors. The influence of social capital was 0.232 or 5.4%, toward self regulated learning, while the remaining (94.6%) was influenced by other factors. Simultaneously, the emotional intelligence and social capital influenced 33.2% toward self regulated learning and the remaining (66.8%) was influenced by other factors. In this study the variables of emotional intelligence has the most impact on self regulated learning. The implication showed that the student’s self regulated learning could be enhanced by increasing the students’ emotional intelligence and social capital.
The Role of Triglyceride-rich Lipoproteins and Their Remnants in Atherosclerotic Cardiovascular Disease
Authors: Gabani Mohanad , Shapiro Michael D , Toth Peter P
Published: October 2023

Atherosclerotic cardiovascular disease (ASCVD) is the world’s leading cause of death. ASCVD has multiple mediators that therapeutic interventions target, such as dyslipidaemia, hypertension, diabetes and heightened systemic inflammatory tone, among others. LDL cholesterol is one of the most well-studied and established mediators targeted for primary and secondary prevention of ASCVD. However, despite the strength of evidence supporting LDL cholesterol reduction by multiple management strategies, ASCVD events can still recur, even in patients whose LDL cholesterol has been very aggressively reduced. Hypertriglyceridaemia and elevated levels of triglyceride-rich lipoproteins (TRLs) may be key contributors to ASCVD residual risk. Several observational and genetic epidemiological studies have highlighted the causal role of triglycerides within the TRLs and/or their remnant cholesterol in the development and progression of ASCVD. TRLs consist of intestinally derived chylomicrons and hepatically synthesised very LDL. Lifestyle modification has been considered the first line intervention for managing hypertriglyceridaemia. Multiple novel targeted therapies are in development, and have shown efficacy in the preclinical and clinical phases of study in managing hypertriglyceridaemia and elevated TRLs. This comprehensive review provides an overview of the biology, pathogenicity, epidemiology, and genetics of triglycerides and TRLs, and how they impact the risk for ASCVD. In addition, we provide a summary of currently available and novel emerging triglyceride-lowering therapies in development.
First record of Hauxwell’s Thrush (Turdus hauxwelli Lawrence, 1869) (Passeriformes, Turdidae) from Goiás state, Brazil
Authors: Santos Estevão F. , Oliveira Jayrson A. , De Luca André C.
Published: October 2023

We report the first record of Turdus hauxwelli Lawrence, 1869, Hauxwell’s Thrush, from the state of Goiás, central Brazil, based on photographic and vocal records obtained at Taquaral de Goiás. This new record substantially expands the species’ distribution beyond the Amazonian domain and marks its new easternmost geographical limit. The new record extends this species’ distribution by 650 km from the nearest recent record. We also discuss the importance of this record in understanding the biogeographical affinities of the seasonal forests of central-western Brazil. 
,,Atomowa Wielkopolska” – plan budowy Elektrowni Jądrowej ,,Warta” w Klempiczu w schyłkowym okresie PRL
Authors: Kujawa Jakub
Published: October 2023

Artykuł dotyczy budowy elektrowni jądrowej w Klempiczu. Autor przedstawił przebieg przygotowań do tej inwestycji i podjął się wyjaśnienia przyczyn rezygnacji z jej realizacji przez władze PRL w 1989 r. Ponadto w artykule znalazł się opis planów lokalizacji elektrowni jądrowej w Klempiczu po roku 1989. W tekście został też scharakteryzowany przebieg protestów społecznych przeciw planom budowy elektrowni jądrowej w Klempiczu.
The Impact of the Business Model on the Size of Investments Received by a Startup at the Series A Stage in the US Market
Authors:   Ural Federal University named after the first President of Russia B.N. Yeltsin, Zubakina Darya A. , Koliasov Pavel E. ,   Ural Federal University named after the first President of Russia B.N. Yeltsin
Published: October 2023

Numerous studies have been devoted to the factors influencing the market success of startups. However, at early stages of startup development, obtaining investments is a priority. Nevertheless, the topic of the influence of various factors, specifically the choice of business model, on the amount of investment received by a startup remains underexplored. Therefore, the aim of this research is to assess the impact of the business model on the amount of investment received by a startup at the Series A stage. The hypothesis being put forward is that the business model patterns utilized by the startup impact the amount of investment received at the Series A stage. To achieve this goal and test the hypothesis, Student's t-test and Mann-Whitney test were applied to a sample of 2313. As a result of the study, the influence of the business model for different industries was revealed. Considering that different business models have varying effects on the amount of investment, models leading to an increase or decrease in investment size were identified for startup founders. The results of this article enable startups to compare their chosen model with those that allow for larger investments and to adjust their chosen strategy. Additionally, this study stands out due to the uniqueness of the methods applied within the scope of the issues covered in the article and the unique sample size in assessing the impact of the business model factor. The findings of this research serve as a catalyst for incorporating the business model factor into further studies dedicated to a comprehensive assessment of a startup's investment attractiveness and the creation of a machine learning model to predict the success of obtaining investments and the amount of investment a startup can expect.
Lipid metabolism disorders in patients with hypertension and diabetes mellitus: development and current treatment options
Authors: Podzolkov V. I. , Tarzimanova A. I. , Abramova A. A. , Vetluzhskaya M. V. , Medvedev I. D. , Loria I. Zh.
Published: October 2023

The article presents the main mechanisms of development of lipid metabolism disorders and endothelial dysfunction in patients with hypertension (HTN) and type 2 diabetes (T2D), and their contribution to cardiovascular events. Modern approaches to the treatment of hypertension and dyslipidemia in people with type 2 diabetes are considered from the standpoint of the latest clinical guidelines, focusing on fixed-dose combinations as a means of an integrated approach to managing risk factors in comorbid patients. Data are presented on the efficacy and safety of fixed-dose combination of lisinopril, amlodipine and rosuvastatin in patients with hypertension and T2D.
Endothelial protective effect of pitavastatin
Authors: Berns A. S. , Kashtalap V. V.
Published: October 2023

The article discusses topical issues of modern concepts of aging, including vascular aging due to the progression of endothelial dysfunction, atherogenesis, chronic and acute cardiovascular atherosclerosis-­related diseases. Modern potential of anti-aging therapy aimed at slowing the progression of vascular aging and endothelial dysfunction are reflected. A descriptive literature review was carried out based on the analysis of sources from the PubMed, eLibrary databases for the following keywords: endothelium, aging, pitavastatin, anti-aging effect (endothelium, aging, pitavastatin, anti-aging effect). Based on a review, the role of pitavastatin is shown not only as an effective cholesterol-­lowering drug, but also as an agent with a large number of proven pleiotropic effects, as well as an optimal safety profile and a low risk of side effects and drug interactions. On the example of a case, the potential of high-intensity lipid-­lowering therapy with the use of pitavastatin in a comorbid patient are illustrated.
How large language models and artificial intelligence are transforming civil engineering
Authors: Dudhee Vishak , Vukovic Vladimir
Published: October 2023

Large language models with artificial intelligence are transforming the way infrastructure projects are planned, executed and managed. Vishak Dudhee and Vladimir Vukovic of V-Lab say they are unlocking unprecedented efficiency and innovation in civil engineering.
An assessment of potential vertebrate predators of the non-native Green Iguana (Iguana iguana) in Hong Kong
Authors: Mo Matthew , Mo Elouise
Published: October 2023

Biological control is the management of non-native species through the use of their natural enemies. The Green Iguana (Iguana iguana), a large lizard of the Neotropics, has established populations in extralimital countries. There has been an increasing recent pattern of reports of free-living Green Iguanas in Hong Kong, which was the trigger of this desktop assessment of native Hong Kong fauna that may prey upon escaped or released iguanas. A literature review found documented predators of Green Iguanas from 12 vertebrate orders. There were two mammalian orders (Carnivora, Primates), eight avian orders (Cuculiformes, Pelecaniformes, Accipitriformes, Cathartiformes, Falconiformes, Strigiformes, Piciformes, Passeriformes), and two reptilian orders (Squamata, Crocodylia), which are all presently represented in Hong Kong with the exception of the orders Cathartiformes and Crocodylia. Based on knowledge of other taxa documented to prey upon lizards represented in Hong Kong, we suggested additional prospective predators of Green Iguanas from one further mammalian order (Artiodactyla) and one further avian order (Ciconiiformes). Since avian species generally have a greater representation in settled areas, along with stray domestic dogs and cats, we expect these species to be the potential predators most likely to take iguanas when they are first released or escaped.
Epidemiology, pathogenicity, risk factors, and management of Helicobacter pylori infection in Saudi Arabia
Authors: Ibrahim Mutasim E.
Published: October 2023

Helicobacter pylori (H. pylori) is a gastric microbial pathogen that infects approximately half of the global population. This bacterium significantly contributes to various gastroduodenal diseases, including chronic active gastritis, peptic ulcerations, and malignant transformations. This review focuses on epidemiology, pathogenicity, virulence genes, risk factors, and management of H. pylori infection, specifically within the context of Saudi Arabia. The results presented here are grounded in studies conducted in Saudi Arabia, contrasting with mere bibliographic reviews of findings from other countries. H. pylori infection has been observed in Saudi Arabia, with substantial differences in the prevalence, ranging between 10-96% among various studied populations. Several risk factors for H. pylori infection have been identified, encompassing socioeconomic status, medical history, personal hygiene, and behavioral practices. Among the virulence genes harbored by H. pylori, cytotoxin-associated gene A (cagA) and vacuolating cytotoxin (vacA) are most common, with their presence correlating with the pathogenicity and clinical manifestations of the associated diseases. A range of invasive and non-invasive diagnostic assays have been utilized to identify H. pylori infection, with their employment being influenced by factors like availability, cost, patient age, gastric symptoms, and the specifics of clinical information sought. While detection methods like the H. pylori stool antigen test and the urea breath test offer more accuracy and speed, culturing remains indispensable for determining the antimicrobial susceptibility profile. The emergence of resistant strains across varying regional settings poses a significant challenge to treatment endeavors, necessitating an assessment of local antimicrobial resistance rates prior to formulating treatment strategies. The findings of this review highlight the importance of continuous implementation of screening, control, and prevention of H. pylori infection to combat the spreading infection and other related complications.
Indigenous Activism and the Healing Power of Storytelling
Authors: Saidero Deborah
Published: October 2023

Nelle culture orali dei popoli indigeni lo storytelling svolge un prominente ruolo epistemologico, pedagogico e terapeutico assicurando sia la trasmissione del sapere ancestrale che le interrelazioni comunitarie. Il saggio esamina come le scrittrici indigene nord-americane Jeanette Armstrong e Lee Maracle incorporano le tradizioni orali dei loro popoli nei loro romanzi con l’intento attivista di promuovere la decolonizzazione dell’ideologia patriarcale e spronare l’umanità ad abbracciare un’etica di ‘ecologia relazionale’ che ristabilisca il rispetto per la Madre Terra. Le loro storie possono aiutare il pubblico indigeno e non ad intraprendere un processo collettivo di guarigione dalle molteplici forme di violenza coloniale.
An investigation on the mathematics teaching programs for gifted students based on teachers' opinions
Authors: ZENGİN Derya , TAPAN BROUTIN Menekşe Seden
Published: October 2023

This study reflects teachers' opinions about the mathematics teaching programs for gifted students. As a method, " a case study", which is qualitative research, was used to reveal the existing problems related to a problem or situation in detail and to offer solutions. During the academic year 2022-2023, a study was conducted in Türkiye with 57 mathematics teachers who work with gifted students in support education rooms and Science and Art Centers (SAC). Data were collected using a structured interview form prepared on Google Forms. The content analysis method was used to interpret and make sense of the data. Participants' opinions on the educational needs, teacher competencies, mental and physical characteristics of gifted students, software use and mathematical proof processes were analyzed and various results were obtained. In this study, to increase the effectiveness of the program, it was suggested that the program should be updated by taking teachers' opinions into consideration, differentiated and enriched activities should be prepared by integrating technology, workshops should be equipped, and in-service training should be provided in various fields. It was also suggested that it would be beneficial to use a common program accepted all over the world in the education process of these children. Recommendations also include a common pathway for students, directing them to universities in line with their abilities and creating specific employment opportunities after graduation.
Biochemical assays and evaluation v1
Authors: not provided lparra
Published: October 2023

Preparation of brain and Neuro2A lysates
BILATERAL INTERNAL THORACIC ARTERY GRAFTING: FIFTEEN YEARS OF EXPERIENCE
Authors: Frolov Alexey V. , Zagorodnikov Nikita I. , Ivanov Sergey V. , Tarasov Roman S. , Barbarash Leonid S.
Published: October 2023

Highlights

Bilateral internal thoracic artery (BITA) grafting is one of the most effective methods of direct myocardial revascularization. However, its results are still contradictory, despite the worldwide trend to use more autogenous arterial conduits.

This study involves more than fifteen years of data in the use of BITA in Kuzbass in coronary artery disease surgery. The findings presented in the course of the analysis confirm the need to use both internal mammary arteries more actively.

 

Aim. To analyze long-term results of BITA grafting in terms of more than 15 years follow-up.

Methods. The study included 232 patients who were admitted at the Cardiac Surgery Department for coronary artery bypass grafting (CABG). All patients were divided into 2 groups depending on usage of single or bilateral internal thoracic artery conduits. Both groups included an equal number of patients 116 (50%). Long-term results were assessed in terms of more than 15 years follow-up.

Results. BITA grafting is comparable with CABG in such major adverse cardiac and cerebrovascular events as repeated myocardial revascularization, stroke, and in combined endpoint such as myocardial infarction (MI), stroke, repeated myocardial revascularization, or patient’s death within 15 years. However, the BITA group is superior to the CABG group in freedom from MI, all-cause deaths, showing a higher life expectancy after surgery (p = 0.011), and improved left ventricular ejection fraction and decreased functional class of angina. Moreover, in the present research it was confirmed that the severity of atherosclerosis in the coronary arteries is lower after bypassing with autogenous arterial conduits.

Conclusion. BITA is safe procedure comparable with CABG, however, it has more advantageous long-term clinical and angiographic results.
ECHOCARDIOGRAPHIC PREDICTORS OF ADVERSE CLINICAL EVENTS IN HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN COMBINATION WITH OBSTRUCTIVE SLEEP APNEA
Authors: Yakovlev Alexey V. , Efremov Ivan A. , Ryabikov Andrey N. , Yakovleva Natalia F. , Shirokikh Ilya V. , Shilov Sergey N. , Teplyakov Alexander T. , Grakova Elena V. , Kopeva Kristina V.
Published: October 2023

Highlights

Repeated hospitalizations occupy a special place in adverse clinical events in heart failure, currently representing one of the most powerful predictors of adverse outcomes in this group of patients. Echocardiographic parameters such as longitudinal myocardial deformation, displacement in the annulus of the tricuspid valve, and left atrial volume index can serve as predictors of hospitalization for cardiovascular diseases in patients with heart failure with preserved ejection fraction and obstructive sleep apnea.

 

Abstract

Aim. To study the prognostic role of individual echocardiographic parameters in heart failure with preserved ejection fraction (HFpEF) in patients with arterial hypertension and obstructive sleep apnea (OSA).

Methods. The study included 59 men with hypertension and OSA (apnea/hypopnea index >15 per hour). At baseline all patients underwent a sleep study and echocardiography with an additional assessment of the global longitudinal strain (GLS). Upon inclusion in the study and after 12 months of follow-up, a 6-minute walk test was performed. After 12 months, the clinical course of the disease was retrospectively assessed. The criteria for an adverse clinical course were episodes of hospitalization for cardiovascular diseases, the development of paroxysmal atrial fibrillation or high-grade ventricular arrhythmias (III–V class according to Ryan), worsening of heart failure with a transition to a higher functional class according to NYHA.

Results. Significant differences were found in several echocardiographic parameters between the groups of patients with and without hospitalizations within 12 months of follow-up: tricuspid annular plane systolic excursion (TAPSE) (p = 0.017), GLS (p = 0.005), left atrial volume index (LAVI) (p = 0.032). According to the regression analysis results, TAPSE, GLS and left ventricular ejection fraction make a statistically significant contribution to the probability of hospitalizations among the evaluated echocardiographic predictors.

Conclusion. The results of the study allow us to consider certain echocardiographic parameters, in particular GLS, TAPSE and LAVI, as predictors of hospitalizations in patients with HFpEF and OSA.
TYPE 2 MYOCARDIAL INFARCTION: A MODERN VIEW ON THE PROBLEM
Authors: Motova Anna V. , Karetnikova Victoria N. , Barbarash Olga L.
Published: October 2023

Highlights

The article describes the main differences between the types of myocardial infarction, in particular, differences between type 1 and type 2 myocardial infarction, the complexity of diagnosis and management of patients with myocardial infarction type 2, and summarizes data on the prevalence of patients with myocardial infarction type 2. The arguments supporting the need for further researches to differentiate various phenotypes of myocardial infarction are provided.

 

Abstract

Despite the high interest in the study of type 2 MI, many unresolved issues concerning diagnosis, criteria for diagnosis and, especially, therapeutic tactics remain unresolved. The available data regarding type 2 MI remain limited and inconsistent, and are based on sources that include the analysis of type 1 MI. According to various predictions, the prevalence of type 2 MI will increase even more. Type 2 MI management strategy should be patient-specific and in accordance with the etiology and pathogenesis, therefore, timely diagnosis, and MI differentiation according to universally accepted definitions is a relevant scientific topic and a practical necessity.

Thus, summarizing all the above, we can say that type 2 myocardial infarction is a topic that encompasses many unresolved issues concerning diagnosis, patient management and further secondary prevention.
SIGNIFICANCE OF OPIOID, CANNABINOID, BRADYKININ RECEPTORS AND КАТP-CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF ADAPTATION TO COLD
Authors: Voronkov Nikita S. , Maslov Leonid N. , Bushov Yuri V.
Published: October 2023

Highlights

It has been shown that chronic adaptation to cold (28 days, +2 – +4°C) has a cardioprotective effect in in vivo model of myocardial ischemia/reperfusion injury in rats. Certain types of receptors and КАТP-channels might be involved in mechanisms of this effect.

 

Aim. To evaluate the role of opioid, cannabinoid, bradykinin receptors and the КАТP-channels in the infarct-limiting effect of chronic adaptation to cold.

Methods. The study involved male Wistar rats weighing 250–300 g. Rats (two in a cage) were placed in a refrigerator for 28 days. The temperature inside the chamber was +2 – +4oC. The infarct-limiting effect of chronic adaptation to cold and its possible cancelation by receptor blockers was studied in a 45-minute coronary artery occlusion and a 120-minute reperfusion of the rat myocardium in vivo. The quantitative assessment of myocardial injury was determined by the necrotic zone to the area at risk (NZ/AAR) ratio.

Results. We have found that КАТP-channels are involved in the mechanism of the infarct-limiting effect of chronic adaptation to cold. Opioid, cannabinoid and bradykinin receptors are not involved in this effect.

Conclusion. The obtained results have expanded our understanding of cold adaptation, as well as receptor pathways involved in the mechanism of ischemia/reperfusion injury resistance. Further studying of the signaling and receptor pathways of the infarct-limiting effect of cold adaptation will reveal molecules responsible for tolerance to ischemia/reperfusion injury. These molecules can be used to develop novel cardioprotective drugs for the treatment of acute myocardial infarction.
PREMATURITY AND THE MECHANICS OF THE INFANT HEART
Authors: Pavlyukova Elena N. , Kolosova Marina V. , Poddubny Vasily V. , Neklyudova Galina V. , Karpov Rostislav S.
Published: October 2023

Highlights

The differences in the postnatal ontogenesis of the heart in children from one to five years old born prematurely and with low, very low, and extremely low birth weight were revealed. The coexistence of different models in contractile-rotational processes of the left ventricle was demonstrated.

 

Abstract

Aim. To expand the traditional ideas about the left ventricle (LV) mechanics formation processes in children born with low, very low and extremely low body weight in the postnatal period during the process of growth and development.

Methods. The study was conducted in 237 children aged from one to five years old: 51 children born healthy and full-term (FT), 68 children born with low body weight (LBW) and 118 children born with very low (VLBW) and extremely low body weight (ELBW). The analysis of clinical, anamnestic data, indicators of standard echocardiography and LV mechanics was performed using discriminant analysis. To demonstrate the assessment of remoteness or proximity between clinical groups, the Mahalanobis distance was used. Visualization of the structure distribution of groups in a multidimensional feature space was carried out in the coordinates of the first two discriminant functions (canonical roots, canonical variables) of discriminant analysis. The evaluation of the discriminant functions significance was verified by Wilks statistics. Statistical analysis was performed on a personal computer using the Statistica program (version 12).

Results. The most informative criteria for F (8.462) = 100,84 are “body weight at birth” (p = 0.000000), “character of feeding up to a year” (p = 0.000000) and direction of apex rotation (p = 0.0098).

Conclusion. The use of discriminant analysis makes it possible to establish a change in the degree of the selected criteria influence on the level of differences between clinical groups, demonstrating fundamentally new aspects of a child's heart mechanics formation in the history of prematurity.
CARDIAC ONCOLOGY: A MODERN VIEW ON THE PROBLEM OF CHOOSING AN OPTIMAL STRATEGY FOR THE TREATMENT OF CORONARY ARTERY DISEASE AND CANCER
Authors: Alekyan Bagrat G. , Karapetyan Narek G. , Gritskevich Aleksandr A. , Gyoletsyan Lilit G. , Galstyan Arthur V. , Revishvili Amiran Sh.
Published: October 2023

Highlights

The article presents an overview of the main studies on the treatment of patients with coronary artery disease and cancer.

 

Abstract

Cardiovascular and oncological diseases remain the leading causes of death globally. The combination of coronary artery disease and cancer is becoming more common in clinical practice. Despite the achievements in the treatment of both of these diseases separately, their combination is a considerable issue for specialists. This review article discusses the main issues of managing patients with cancer and coronary artery disease. Moreover, the article presents various treatment strategies, including simultaneous and step-by-step interventions, and shows the current trends of endovascular approach to the treatment of these patients.
Experience in the treatment of isolated posttraumatic pancreatic injury complicated by the formation of pseudocysts in a 9-year-old child
Authors: Karpova Irina Y. , Strizhenok Dmitry S. , Myasnikov Dmitry A. , Filkin Anton A. , Dolinskaya Varvara D. , Parshikov Vyacheslav V.
Published: October 2023

The number of cases of traumatic pancreatic damage in children has increased by 1%2% over the last several decades, which is related to an increase in car accidents and the popularity of outdoor sports (cycling and scooter). A 9-year-old boy was admitted to Childrens City Clinical Hospital after being injured in a bicycle fall. The boy complained of pain in the upper abdomen and around the wound on the anterior abdominal wall when he was admitted. The victim was conscious during the examination, the abdomen was not bloated, soft, or uncomfortable on probing in the higher portions, and peritoneal symptoms were negative. An ultrasound examination of the abdominal organs revealed symptoms of pancreatic injury, including the creation of a hematoma up to 58 mL in size. The general blood test found leukocytosis (12.75 109/L) and an increase in amylase up to 1,664 U/L. Following preoperative preparation, a diagnostic laparoscopy was conducted, which included opening and draining the omental sac, as well as cleanliness and drainage of the abdominal cavity. The patient was given antimicrobial, hemostatic, infusion therapy, pancreatic secretion inhibitors, and food nutrition following the procedure. During the dynamics of the ultrasound examination, a pseudocyst of the pancreas with a volume of up to 22 mL was noted. The situation improved with treatment, the amylase indices reduced (271 U/L), and the child was discharged home 44 days a day. After 4.5 months, the cyst increased to 320 mL; therefore, during planned hospitalization, a laparotomy was performed with the imposition of pancreatocystojejunoanastomosis on the Roux-enabled loop. The postoperative time was uneventful, and the child was released from the hospital on the 14th day. The diagnosis was confirmed through laparoscopy, and the omental sac and abdominal cavity were sterilized before drainage. Constant monitoring of the ultrasound image of the pancreatoduodenal zone and the dynamics of amylase markers allowed for the identification and evaluation of posttraumatic changes in the pancreas. An increase in the volume of the pseudocyst served as an indication for the imposition of pancreatocystojejunoanastomosis on the Roux-en-Y loop.
SKS Polarization Anomalies Due to the Coriolis Force
Authors: Creasy Neala , Bozdağ Ebru , Frost Daniel A. , Snieder Roel
Published: October 2023

The Earth’s Coriolis force has been well-known to impact surface waves and normal modes, which is essential to accurately interpret these waves. However, the Coriolis force on body waves has been assumed to be negligible and mostly ignored. It has been previously shown that the Coriolis force impacts polarizations of shear waves, whereas the wavefronts remain unaffected. We expand on the potential influences of Earth’s Coriolis force on shear-wave polarization measurements by conducting 3D numerical simulations for elastic waves generated by earthquake and explosive sources in a radially symmetric, and 3D mantle and crustal models. The Coriolis force can produce polarization anomalies of mantle shear waves up to 7° and core phases, such as SKS and SKKS, up to 4°. Uncorrected shear-wave polarizations due to the Coriolis force can cause an additional source of error (5°–10° in fast direction, and 0.2–0.3 s delay time depending on the method and seismic phase), inaccurate interpretation of station misalignments, and imprecise estimates of the core–mantle boundary topography. We show how to correct for the Coriolis force on teleseismic shear waves using 1D ray tracing for well-isolated phases. We recommend the use of full waveform simulations to accurately account for earthquake sources parameters, poorly isolated phases that could include interfering phase arrivals within the measurement time window, and the effect of the Coriolis force on the polarizations of shear waves.
Autonomous Earthquake Location via Deep Reinforcement Learning
Authors: Kuang Wenhuan , Yuan Congcong , Zou Zhihui , Zhang Jie , Zhang Wei
Published: October 2023

Recent advances in artificial intelligence allow seismologists to upgrade the workflow for locating earthquakes. The standard workflow concatenates a sequence of data processing modules, including event detection, phase picking, association, and event location, with elaborately fine-tuned parameters, lacking automation and convenience. Here, we leverage deep reinforcement learning and develop a state-of-the-art earthquake robot (EQBot) to help advance automated earthquake location. The EQBot learns from tremendous trial-and-error explorations, which aims to best align the observed P and S waves, complying with the geophysical principle of gather alignments in source imaging. After training on earthquakes (M ≥ 2.0) for a decade in the Los Angeles region, it can locate earthquakes directly from waveforms with mean absolute errors of 1.32 km, 1.35 km, and 1.96 km in latitude, longitude, and depth, respectively, closely comparable to the cataloged locations. Moreover, it can automatically implement quality control by examining the alignments of P and S waves. Our study provides a new solution to advance the earthquake location process toward full automation.
Subdaily Ambient Noise Monitoring at Parkfield, California, by Combining C1 and C3
Authors: Meng Yi , Liu Zhikun , Li Tiancheng , Zhang Rui
Published: October 2023

Monitoring the temporal variation in seismic velocity plays a critical role in understanding the dynamic processes of the subsurface at different scales. Many seismic velocity changes related to earthquakes and volcanic activities have been obtained using ambient noise correlation in recent years; however, their temporal resolution is limited, typically from a few to dozens of days, which makes it challenging to explore the valuable but short-duration changes in subsurface media. In this article, we develop a method based on the correlation of the coda of the ambient noise correlation (C3) with a multiple-component combination and introduced singular value decomposition-based Wiener filter denoising technique. Using permanent network data, we achieved subdaily ambient noise monitoring at Parkfield, California, using 4-hr cross-correlation stacking with 2-hr step. We identified that the maximum seismic velocity drop delayed the mainshock of the 2004 Mw 6.0 Parkfield earthquake by ∼41 hr, during which the temporal velocity process may have been affected by strong aftershocks, including an Mw 5.0 aftershock that occurred one day after the mainshock; however, no significant precursory change was detected. Our method provides an opportunity for monitoring the short-term change of underground structures based on the widely distributed seismic networks. In addition, the idea of obtaining reliable subsurface information within a short time through high-order noise correlation in this work has important enlightenment for ambient noise imaging and monitoring in broader fields.
POSITIONING PERFORMANCE OF LOW-COST U-BLOX NEO-M8U MODULE IN URBAN ENVIRONMENT
Authors:   Department of Geoinformatics, Faculty of Mining and Geology, VSB – Technical University of Ostrava, KACMARIK MICHAL , FOJTIK DAVID ,   Department of Control Systems and Instrumentation, Faculty of Mechanical Engineering, VSB – Technical University of Ostrava
Published: October 2023

Global Navigation Satellite System (GNSS) positioning is nowadays used for many applications, including navigation of various man-drived or autonomous vehicles and pedestrians. As a significant part of these activities take place in cities or other environments which are not favourable for GNSS signal transmission, there is an option to improve the quality of positioning in them by combining the GNSS with other technologies. A fusion with inertial measurement units is probably the most common. The main objective of this paper was the evaluation of low-cost u-blox NEO-M8U module in kinematic positioning. Despite the module is primarily aiming on automotive industry, it was tested for a performance in low speed scenarios. The fusion mode combining input from a single-frequency multi-GNSS receiver and inertial unit was initialized and firstly calibrated on a standard passenger car and lately tested on a remotely controlled small vehicle. In a set of testing drives on three individual routes with a speed of motion around 5 km/h, the accuracy of horizontal position of the u-blox M8U module was in 35% of all measurements better than 1 m and in 84% better than 3 m.
OPTIMALISASI VARIAN DAN BRANDING PRODUK HASIL INDUSTRI TAHU DI KECAMATAN BALEN KABUPATEN BOJONEGORO
Authors: Adi Khofifatu Rohmah , Idris Idris , Rosyida Fatiya , Rapita Desinta Dwi
Published: October 2023

OPTIMIZATION OF VARIETY AND BRANDING OF TOFU INDUSTRY PRODUCTS IN BALEN DISTRICT, BOJONEGORO REGENCYThe important thing that can be learned from the 1997 economic crisis that hit Indonesia is that small industries have the ability to survive. Small industries are also a manifestation of the Ekonomi Kerakyatan. The advantages possessed by this small industry encourage policies that can strengthen it. The ability of small industrial players to compete in this era. Efforts for the development of small industries are needed. The problem that often occurs is that they have less knowledge of business development strategies. One of the industries that many people are involved in, especially in Kabunan Village, is the tofu industry. The tofu industry in this village still has a limited number of variations and does not yet have a brand. The implementation method carried out in this service is the preparation made to analyse the situation and needs, implementation, and evaluation of the program. This activity was carried out well. This can be seen from the results of the questionnaire answer that 95 percent of the participants were happy with this socialization, 90 percent were satisfied with the material presented, and 90 percent stated that the material presented was interesting.Hal penting yang dapat dipetik dari krisis ekonomi 1997 yang menghampiri Indonesia adalah bahwa industri kecil memiliki kemampuan bertahan. Industri kecil juga merupakan wujud dari ekonomi kerakyatan. Keunggulan-keunggulan yang dimiliki oleh industri kecil ini mendorong adanya kebijakan yang dapat menguatkannya. Kemampuan pelaku industri kecil dalam bersaing di era seperti saat ini sangat penting untuk dimiliki. Upaya-upaya untuk pengembangan industri kecil sangat diperlukan. Permasalahan yang sering terjadi adalah pelaku industri kecil memiliki pengetahuan yang kurang akan strategi-strategi untuk mengembangkan usaha mereka. salah satu industri yang banyak digeluti masyarakat di Desa Kabunan adalah industri tahu. Industri tahu yang ada di desa ini masih memiliki jumlah variasi yang terbatas dan belum memliki nama dagang. Kegiatan ini bertujuan untuk memberikan pengetahuan tentang variasi produk tahu, dan memperluas wawasan tentang branding produk. Metode pelaksanaan yang dilakukan dalam pengabdian ini adalah persiapan yang dilakukan untuk menganalisis situasi dan kebutuhan, pelaksanaan, dan evaluasi program. Kegiatan ini berjalan dengan baik sebagaimana ditunjukkan pada angket bahwa 95 persen peserta merasa senang dengan adanya kegiatan sosialisasi ini, 90 persen peserta puas dengan materi yang disampaikan, dan 90 persen peserta menyatakan materi yang disampaikan menarik.
TREN FASHION MERK LOKAL: ANTARA GAYA HIDUP DAN REPRESENTASI NASIONALISME DI KALANGAN MAHASISWA UNIVERSITAS NEGERI SEMARANG
Authors: Pradana Bayusar Candra , Wijaya Atika
Published: October 2023

Local brand fashion is a style of dress using original clothing brands made in Indonesia. The trend of using local fashion brands has begun to develop among urban students, one of whom is a Semarang State University (UNNES) student in Semarang City. Local fashion brands also have a connection with nationalism because they are included in domestic products. This article aims to explain how UNNES students interpret local brand fashion trends as part of a lifestyle and find out the meaning of using local brands when associated with nationalism. This research uses qualitative methods. The subjects of this study were active UNNES students. Data collection techniques used in this study were observation, interviews, and documentation. The results of this study indicate that fashion trends for local brands among UNNES students have changed student lifestyle patterns, besides that the use of local brand fashion is a form of love for UNNES students for domestic products. UNNES students represent a sense of nationalism by using local fashion brands which are native domestic products.Fashion merk lokal merupakan gaya berpakaian dengan menggunakan merk pakaian asli buatan Indonesia. Tren penggunaan fashion merk lokal sudah mulai berkembang di kalangan mahasiswa perkotaan, salah satunya adalah mahasiswa Universitas Negeri Semarang (UNNES) yang berada di Kota Semarang. Fashion merk lokal juga memiliki keterkaitan dengan nasionalisme karena termasuk produk dalam negeri. Artikel ini bertujuan untuk menjelaskan bagaimana mahasiswa UNNES memaknai tren fashion merk lokal sebagai bagian dari gaya hidup dan mengetahui makna tindakan menggunakan brand lokal jika dikaitkan dengan nasionalisme. Penelitian ini menggunakan metode kualitatif. Subjek penelitian ini adalah mahasiswa aktif UNNES. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara, dan dokumentasi. Hasil dari penelitian ini menunjukkan bahwa tren fashion merk lokal di kalangan mahasiswa UNNES merubah pola gaya hidup mahasiswa, selain itu penggunaan fashion merk lokal merupakan salah satu bentuk rasa cinta mahasiswa UNNES terhadap produk dalam negeri. Mahasiswa UNNES merepresentasikan rasa nasionalisme dengan cara menggunakan fashion merk lokal yang merupakan produk asli dalam negeri.
Efficacy of intravenous alpha lipoic acid in the treatment of neuropatic pain due to carpal tunnel syndrome
Authors: Öztürk Gülsah , Demiryurek Bekir Enes
Published: October 2023

Background and purpose – In this study, we analyzed the effect of oral and oral + intravenous Alpha-lipoic acid (ALA) treatment on pain level and physical examination findings in patients diagnosed with carpal tunnel syndrome (CTS). Methods – A total of 115 patients patricipated in the study. Physiotherapy and wrist splint were first applied to all patients diagnosed with CTS in the study. 40 patients were treated with oral ALA after iv. ALA therapy, 35 patients received only oral ALA treatment and 40 patients did not receive any medication. The patients were divided into 3 groups as those who received only splint treatment and physiotherapy, those who received oral ALA treatment, and those who received oral ALA treatment after iv. treatment. All patients were assessed before the treatment, and at the 1st and 3rd months of the treatment. In clinical assessment, visual analog scale (VAS) forms were filled to define the pain severity, the Boston symptom severity scale (BSSS) and Boston functional status scale (BFDS) were filled for evaluating symptoms and functional status. Results – VAS, BSSS and BFDS scores of the patients who were treated with intravenous and then oral ALA were found to be significantly lower at the end of both the 1st and 3rd months compared to the patients who received only oral ALA or no medication (p=0.001; p<0.001), (p=0.001; p<0.001), (p=0.006; p<0.001). Conclusion – We think that iv. ALA is effective in the treatment of symptoms associated with CTS.