bluuebunny/crossref_metadata_2025 huggingface dataset:
Formação inicial do pedagogo para integrar as TDIC às práticas educativas: um estudo de caso
Authors: Marfim Lucas , Pesce Lucila
Published: January 2020

O presente artigo deriva de uma pesquisa que teve por objetivo investigar em que medida os processos formativos que inserem e tematizam a integração das Tecnologias Digitais de Informação e Comunicação (TDIC) ao campo da Educação, no curso de Pedagogia de uma universidade federal, no estado de São Paulo, contribuem para a formação de seus licenciandos. Para tanto, considerou a experiência cotidiana dos licenciandos com as TDIC, as requisições para seu uso, pela universidade, e as experiências formativas vivenciadas nas disciplinas que tematizam as relações entre TDIC e Educação. A investigação é concebida sob a ótica da pesquisa qualitativa, em caráter de estudo de caso. Estabeleceu-se como instrumentos de produção de dados, a aplicação de questionário aberto-fechado e de entrevistas semiestruturadas e como método de exame dos dados, a análise estatística descritiva e a análise temática de conteúdo. Os achados revelaram um papel secundarizado na incorporação, problematização e discussão das relações envoltas às TDIC e aos processos de ensino e aprendizagem, posto que sua tematização direta seja disposta apenas em disciplinas de caráter eletivo. Também foi constatado que a relação TDIC-Educação acaba por se circunscrever à discussão dos aparatos tecnológicos como ferramentas didático-metodológicas, no exercício da docência. Da discussão dos resultados emerge como principal apontamento, o desafio de que o processo formativo proporcione uma relação em que as TDIC estejam imbricadas às práticas socioculturais vivenciadas pelos sujeitos, demandando a integração das TDIC, em todo o curso, de forma transversal e como processo cultural, para além do estritamente pedagógico.
papel das mídias digitais e da literacia digital na educação não-formal em saúde
Authors: Yamaguchi Mirian Ueda , Barros Josiane Kelly de , Souza Rosane Clys de Barros , Bernuci Marcelo Picinin , Oliveira Leonardo Pestillo de
Published: January 2020

Literacia digital em saúde envolve a capacidade do indivíduo em interpretar, avaliar e usar de forma eficaz as informações de saúde obtidas por meio das mídias digitais, permitindo-o tomar decisões e ter maior autonomia sobre sua saúde. Considerando a crescente utilização das mídias digitais como fonte de informações em saúde para população, o presente estudo objetivou avaliar o nível de literacia digital em saúde de indivíduos que fazem uso das mídias digitais. O estudo foi desenvolvido com uma amostra de 423 indivíduos por meio de questionário digital para obtenção de dados socioeconômicos e o instrumento eHealth literacy scale (eHeals) foi utilizado para avaliar o nível de literacia digital em saúde. Os resultados indicaram que maior nível de escolaridade e renda correlaciona com maiores níveis de literacia digital em saúde. Os determinantes biológicos idade e sexo não apresentaram correlação com a literacia digital. Conclui-se que a estratégia do governo que busca, por exemplo, utilizar as redes sociais online Facebook, Instagram e Twiter como alternativa de educação não-formal em saúde deve considerar que o êxito dessa estratégia perpassa pela necessidade de investir na educação formal.
Desenho animado e imaginário infantil de massa: narrativas, mito e mídias na mediação escolar
Authors: Odinino Juliane Di Paula Queiroz , Souza Gustavo José Assunção de
Published: January 2020

O presente artigo busca compreender como os repertórios midiáticos endereçados aos públicos infantis participam na constituição do imaginário da cultura de massa, pelo qual a linguagem do desenho animado tem desfrutado de uma centralidade no cenário globalizado, a partir das matrizes culturais e dos mitos que o povoam e o delineiam. Realizando aproximações conceituais entre cultura de massa e imaginário infantil, a análise visa oferecer subsídios para educar crianças para/sobre, com e através das mídias, por meio de uma perspectiva educacional transformadora, crítica e cidadã. A metodologia utilizada parte de um levantamento teórico-conceitual sobre clássicos da cultura de massa (MORIN, 1975; ECO, 1970) e do mito (ELIADE, 2016; BARTHES, 1989) e na medida em que traz elementos para compreender esta relação remete, por sua vez, à forma como o imaginário infantil é constituído. Dialoga com autores da mídia-educação (FANTIN, 2006; BUCKINGHAM, 2013) no sentido de ampliar as possibilidades de reflexão crítica e de usos das mídias na escola, espaço privilegiado de constituição de coletivos infantis e, portanto, de mediação cultural. Tais análises apontam que a cultura de massa apresenta uma inerente contrariedade, com características apocalípticas e integradoras simultaneamente, mesmo nos dias atuais, as quais compõem significativamente e garantem inteligibilidade à cultura da infância na contemporaneidade. O artigo, a partir das reflexões sobre a complexa relação entre mito, narrativa e imaginário infantil, apresenta nas considerações finais inúmeras possibilidades de usos dos desenhos animados, ao discorrer sobre as possibilidades da mediação pedagógica com vistas à qualificação e à promoção de uma recepção e imaginação infantil mais crítica, diversificada e participativa.
Cultura da leitura e escrita em práticas mídia-educativas nas escolas municipais do Rio de Janeiro
Authors: Sá Patrícia Teixeira de , Fonseca Mirna Juliana Santos , Machado Carla Silva
Published: January 2020

Em 2015, a Gerência de Mídia e Educação/SME-RJ, o Instituto Desiderata e o Grupo de Pesquisa em Educação e Mídia da PUC-Rio realizaram uma pesquisa quantitativa sobre práticas mídia-educativas, que contou com participação de 911 escolas da rede municipal e apontou a baixa recorrência de produção de mídias digitais e audiovisuais nas escolas. Alguns números dos questionários respondidos chamam a atenção: 90,6% das escolas assinalaram “assistir a filmes/vídeos” com frequência, enquanto 53,7% apontaram nunca ter produzido vídeos com os alunos. Os resultados indicam estar consolidadas nessas escolas práticas mídia-educativas que têm por base a produção de materiais ligados à cultura da leitura e escrita, como livros, fanzines e jornais. A partir desses dados, este artigo tem por objetivo estruturar argumentos para a compreensão desse cenário, com foco na análise comparativa entre políticas públicas de promoção da leitura e de práticas mídia-educativas, a fim de levantar questões sobre o papel das mídias digitais na cultura escolar, levando em conta que os estudantes atuam nas redes virtuais, compartilhando opiniões e produzindo conteúdos. Cultura escolar, mídia-educação, literacia digital são os conceitos que permitem o adensamento do debate sobre esse tema. A pesquisa conclui que as práticas mídia-educativas latentes no cotidiano dessas escolas ocorrem por meio de ações isoladas de professores e coletivos, e argumenta sobre a necessidade de uma articulação institucional sistematizada e prolongada para que a aprendizagem escolar se enriqueça com o potencial representado pelo uso das mídias digitais e audiovisuais na contemporaneidade.
perspectivas de tecnologia dos educadores em formação: valores em disputa
Authors: Espíndola Marina Bazzo de , Cerny Rosely Zen , Xavier Rachel Seixas
Published: January 2020

O estudo aqui apresentado tem como objetivo analisar os valores atribuídos às tecnologias digitais na prática educativa, a partir da pesquisa nas produções das Narrativas Digitais realizadas no Curso de Especialização Educação na Cultura Digital por educadores da rede pública de Santa Catarina (SC). A partir dos trabalhos de Feenberg (2013) e Selwyn (2011; 2014) acerca da Teoria Crítica da Tecnologia e das ideologias da Tecnologia Educacional, buscou-se, por meio da análise de conteúdo (BARDIN, 1977), identificar quais os valores atribuídos às TDIC nas narrativas digitais produzidas pelos educadores em formação. Os resultados mostram que, neste processo de reflexão, os valores atribuídos pelos professores as TDIC nas práticas pedagógicas, são, em geral, contraditórios, mas podem ser categorizados em duas perspectivas principais: a de 1) Tecnologia como Eficácia e Progresso e 2) Tecnologia como Possibilidade Democrática e Ressignificação das Práticas Educativas.
GAS-PUFF TARGET FOR LASER-PRODUCING PLASMA SXR SOURCE
Authors: Salačová Šárka , Wachulak Przemyslaw , Tatíček Milan , Vrbová Miroslava
Published: January 2020

Mass density spatial distributions of selected gas-puff targets have been determined by radiography, using quasi-monochromatic radiation at a wavelength of 13 nm. Results of spatial distributions of mass densities at various initial reservoir pressures for Nitrogen, Argon and Krypton targets are presented. Changes in the mass density spatial distribution due to a nozzle wear are reported.
Heteronormativität als Verhinderung? Oder warum die ›Die Ehe für alle‹ in Österreich (noch) eine Frage des Gewissens ist
Authors: Scheiwiller Thomas
Published: January 2020

The acceptance of alternative lifestyles concerning diverse family models and sexual orientation remains a challenging issue for churches. In 2019 marriage was legally equated with a civil union in Austria - the legal form can now be chosen independently of sexual orientation. As a result, the Evangelical Lutheran Church felt compelled to re-evaluate marriage as its preferred legal form in a synodal meeting. The synodal document shows that a compromise was sought between the socio-politically conservative and the liberal wing of the church. The aim of this essay is to draw attention to the tensions, inconsistencies and attempts of harmonization evident in terms such as ›creation‹, ›conscience‹ or ›blessing‹ which have been left open to interpretation, while the term ›marriage ceremony‹ (Trauung) has been omitted altogether in order to avoid conflict.
Abendland und Apokalypse. Die »Ökumene des Hasses« und das Verhältnis der letzten zu den vorletzten Dingen
Authors: Meyer Lukas David
Published: January 2020

Despite the debate about »ecumenism of hate« (Spadaro) in the United States and general fear of Islam, there is a lack of theological analysis of new alliance between catholic integralism and evangelical fundamentalism. This article focusses on tensions between main-line churches and sects in Europe and the United States and examines apocalyptic thought during Reformation, Enlightenment and modern times in order to identify current challenges. To tackle apocalyptic agenda in geopolitics of 21st century theologically, the author proposes a re-lecture of the differentiation between »ultimate and penultimate things« (Dietrich Bonhoeffer). This requires both self-criticism and commitment to ecumenical understanding, which could lead to a rejuvenation of political culture.
Baixa Representatividade Feminina na Política
Authors: De Toledo Cláudia Mansani Queda , Jardim Neymilson Carlos
Published: January 2020

A presente pesquisa tem como propósito teórico, a análise da baixa representatividade feminina na política como um obstáculo a ser vencido na democracia brasileira. Sabe-se que é necessário discutir a paridade de gênero como uma estratégia para eliminar obstáculos existentes que impedem as mulheres de viver com igualdade no cenário político brasileiro. As mulheres são mais da metade da população brasileira, mas, atualmente, ocupam apenas 10% das Casas Legislativas em nosso país. Assim sendo, analisaremos o papel da mulher no cenário da política brasileira, bem como a importância da paridade da participação feminina no Congresso Nacional, e o ideal igualitário das mulheres na política do Brasil, no intuito de propor mecanismo para a superação da desigualdade de gênero que prevalece na esfera política do nosso país. Para serem atingidos esses resultados, a pesquisa fará uma abordagem bibliográfica mediante uma metodologia analítica, utilizando-se de livros, artigos e doutrinas para melhor compreensão do tema.
Representação, Democracia e Candidatura Avulsa no Brasil
Authors: Guerra Caio Grande , Val Eduardo Manuel
Published: January 2020

Não obstante de diversos temas da atualidade, quais sejam, judicialização da política, ativismo judicial, crise de representatividade, candidaturas avulsas, dentre outros, o presente artigo tem o condão de tratar de forma analítica o agravo do recurso extraordinário n. 1.054.490 do Supremo Tribunal Federal, que versa sobre a possibilidade das candidaturas avulsas no Brasil. Além disso, importa divagar sobre de que forma o poder judiciário tem atuado nesse caso tão importante para o destino político nacional.
A Proteção Diplomática no Direito Internacional Contemporâneo
Authors: Carlos Lima Lucas
Published: January 2020

O presente artigo pretende analisar o papel da nacionalidade na efetivação do instituto da proteção diplomática. Para tanto, a linha interrogativa neste trabalho desenvolver-se-á em três partes. As duas primeiras partes deste artigo são descritivas. Visam uma análise do regime jurídico atual no direito internacional relativo a proteção diplomática e o papel da nacionalidade na proteção diplomática, sobretudo pela maneira como a matéria veio codificada nos Artigos sobre Proteção Diplomática (APD) de 2006. Na terceira parte, serão explorados os problemas da proteção diplomática nos quais a nacionalidade não desempenha papel predominante no exercício do instituto por parte dos Estados. Cuida-se, em específico, da situação dos refugiados e apátridas, bem como a situação da espécie de proteção diplomática oferecida pelo direito do mar em relação a embarcações. Algumas reflexões com base no exame da prática recente são tecidas nas considerações finais, sobretudo perquirindo-se à indagação de potenciais tendências futuras do instituto.
Narrative Exposure Therapy for the Integration of Migrants with PTSD in the Light of MIPEX Integration Project in Europe
Authors: Khalid Aqsa
Published: January 2020

People who migrate in uncertain and traumatic circumstances can suffer from symptoms of Post-Traumatic Stress Disorder (PTSD). The life they will live after traumatic events can affect the process of treatment and healing. Daily stressors in host communities including basic survival needs, insecure and unhygienic shelter, lack of social support, language and cultural barriers, low socioeconomic status, and job insecurity can affect the process of integration negatively. This paper will explore the literature to understand the effects of short-term Narrative Exposure Therapy (NET) along with the role of Migrant Integration Policy Index (MIPEX) tool on the integration of migrants suffering from PTSD. Literature supports that NET is effective as it has shown to help reduce the symptoms of PTSD in migrants, but social factors and daily stressors can become a hindrance in treatment. Some MIPEX tool indicators address the daily stressors which are required to decrease the symptoms of PTSD. Therefore, research concludes that NET and some MIPEX tool indicators if implemented correctly and simultaneously can help in reducing symptoms of PTSD and eventually help migrants better integrated.
Cultura do Estupro e a Culpabilização da Vítima de Violência Sexual
Authors: Ramos da Silva Vanessa
Published: January 2020

A partir de acórdão julgado em julho de 2019 pelo Tribunal de Justiça do Rio Grande do Sul - Apelação Crime n. 70080574668 - em um caso de estupro praticado por um motorista do aplicativo Cabify contra uma usuária, levanta-se questões acerca da cultura do estupro e a culpabilização das vítimas de violência sexual pelo Poder Judiciário.
Badania czytelnictwa w społeczności esperanckiej
Authors: Fischer-Kotowski Paweł
Published: January 2020

Badania socjologiczne prowadzone dotychas w społeczności esperanckiej jedynie w niewielkim stopniu koncentrowały się na czytelnictwie książek. Autor artykułu na podstawie własnych badań czytelniczych przeprowadzonych podczas 100. Światowego Kongresu Esperanto (2015) dokonuje porównania poziomu czytelnictwa wśród osób używających języka esperanto z wynikami badań czytelnictwa Biblioteki Narodowej w Warszawie. Mimo trudniejszych warunków rozwoju kultury esperanckiej – brak systemu szkolnictwa, brak zorganizowanych, dobrze finansowanych instytucji kultury – społeczność esperancka jest lepiej wykształcona i czyta więcej książek niż ogół Polaków.
Wywiady z uczestnikami hungarologicznej konferencji w Poznaniu
Authors: . .
Published: January 2020

Wywiady z uczestnikami hungarologicznej konferencji w Poznaniu
Why is Spanish not used as an interlanguage in the Phillipines?
Authors: Jiménez Lobo Félix Manuel
Published: January 2020

This article examines the reasons for the disappearance of Spanish as an interlanguage in the Philippines (both as an official language and as a means of communication between speakers of different languages) after the change of colonial power at the end of the 19th century. First, the author explains the geographic, ethno-linguistic and historical context of the country, summarizes the evolution of Spanish in the Philippines from the beginning of the Spanish colonial period until the present day with special attention being given to the appearance of the creole Chavacano, and presents the traditional explanations for the disappearance of the language. Later he compares the evolution of Spanish in the Philippines with other former Spanish colonies. He concludes that Spanish disappeared through a combination of unique historical circumstances which did not occur in other territories of the former Spanish Empire.
Concept(s) of Interlinguistics
Authors: Barandovská-Frank Věra
Published: January 2020

Interlinguistics was created in order to help establish standards for auxiliary languages. However, over the course of its hundred-year history it has come to be understood in ever broader ways, generally as an interdisciplinary branch of science including various aspects of communication, including language planning and standardization, multilingualism, language policy, translation, sociolinguistics as well as the history and literature of planned languages. This expanded concept makes it possible for different scholars, researchers, associations and organizations to treat interlinguistics from extremely diverse points of view and for specialists in different sub-fields to work together. On the one hand, there is a clear lack of agreement concerning the subject matter of interlinguistics as can be seen, for example, in Wikipedia entries. On the other hand a broad understanding opens up new horizons for interlinguistics and makes deeper specialization in individual areas possible. It is therefore possible to see the future of interlinguistics in a positive light: there are still many interesting fields to discover whether through a reanalysis of historical documents or following the latest wave in internet-supported language construction and the activity of polyglots or observing the birth of new scientific specializations and sub-branches such as Slavic interlinguistics.
On Not Being Lost in Translation: Creative Strategies to Approach Multiculturalism in Esperanto
Authors: Burghelea Manuela
Published: January 2020

This article examines translation practices into Esperanto, a constructed language with 130 years of existence and which is meant to serve neutral international communication. As such, one of Esperanto’s practical applications is to render works from around the world and from different times accessible to a worldwide community of speakers. We analyse the role played by translation in the development of Esperanto and in the creation of an Esperanto community. We argue that translation into Esperanto possesses a key social function and conveys values that go beyond the mere transfer of semantics. In doing so, we apply an interdisciplinary perspective and draw on approaches from translation studies, linguistics, anthropology and intercultural communication studies. Placing these approaches within a dialogue is beneficial for a deeper understanding of the various strategies employed by Esperanto translators in order to accommodate and to inform the Esperanto cultural horizon.
The role of gender in the use of Hungarian address forms
Authors: Domonkosi Ágnes
Published: January 2020

Forms of address are directly related to the nature of social relationships. The gender of the discourse partners, including the question whether they are of the same or different genders, thus has an impact on the use of forms of address. The goal of this paper is to highlight the major gender-related characteristics of Hungarian address practices by reporting on a comprehensive sociolinguistic study based on questionnaires and interviews. In line with the perspective of social constructivism, the gender-related usage patterns of address forms are interpreted as actively shaping the construal of particular relationships and gender roles rather than merely reflecting them. Thus, the research findings suggest that iterative patterns in the use of more confidential/affectionate forms with women contribute to the maintenance of female gender roles.
Język międzysłowiański jako lingua franca dla Europy Środkowej
Authors: Van Steenbergen Jan
Published: January 2020

Międzysłowiański jest sztucznym językiem pomostowym, opartym na wspólnych elementach języków słowiańskich. Głównym jego celem jest maksymalna zrozumiałość dla Słowian bez żadnej uprzedniej nauki. W dobie globalizacji i masowej turystyki język międzysłowiański otwiera nowe perspektywy dla komunikacji międzynarodowej w Europie Środkowo-Wschodniej. Region ten składa się z wielu, przeważnie małych państw, a niemal każde z nich ma swój własny, mało znany poza własnym terytorium język. Znajomość języka angielskiego i innych języków obcych jest wciąż na niskim poziomie, a wielojęzyczność bierna możliwa jest tylko w ograniczonym zakresie. Ze względu na swój wysoki stopień zrozumiałości wśród Słowian, międzysłowiański stanowi idealną alternatywę w komunikacji jednokierunkowej, np. w przewodnikach, broszurach, ulotkach i na stronach internetowych.
Loanword adaptation in Esperanto
Authors: Oliveira, Gonçalves de Souza de Karina
Published: January 2020

This research investigated the phonological directions by which new roots are incorporated into Esperanto. Words were selected from the following magazines: Kontakto, the official magazine of the Tutmonda Esperantista Junulara Organizo (TEJO – World Esperanto Youth Organization), which was first published in 1963 and has subscribers in over 90 countries, and Esperanto, the official magazine of the Universala Esperanto-Asocio (UEA – Esperanto Universal Association), which was first released in 1905 and has readers in 115 countries, in addition to a technological terminology list (Nevelsteen, 2012) and to words not quoted in dictionaries but published in a list on the blog . Words were collected from 13 different languages: Arabic, Chinese, French, English, Japanese, Komi, Korean, Portuguese, Russian, Spanish, Turkish, Sanskrit and Swahili. The theoretical basis that guided this analysis was Loanword Phonology, mainly the works of Calabrese & Wetzels (2009), Vendelin & Peperkamp (2006), Paradis (1988), Kang (2011), Friesner (2009), Menezes (2013), Chang (2008), Kenstowicz & Suchato (2006) and Roth (1980). An analysis of the corpus showed that words can be adapted by their phonetic form as well as by their root’s orthographic form from the original language. Furthermore, we observed that long vowels were, for the most part, adapted as simple vowels; and some words are present in two synchronic variations.
Komparo de paroloj el retorika vidpunkto
Authors: Åradsson Bengt Olof
Published: January 2020

(Porównanie przemówień z punktu widzenia retoryki). Formalna analizawypowiedzi – retoryka – ma długą tradycję w krajach zachodnich. Od czasów starożytnych i przez następne stulecia nauczano jej na uniwersytetach i w szkołach i wywierała silny wpływ na społeczeństwo. W Chinach i Japonii natomiast tradycje są inne. Badacze zaświadczają o obserwowalnych różnicach w sposobie, w jaki uczniowie z różnych kultur piszą teksty. Rodzima kultura piszących/mówców wpływa na ich teksty i przemówienia. Niniejsze studium miało na celu zbadanie, czy istnieją różnice w wystąpieniach esperantystów z różnych tradycji kulturowych. Obiekty badawcze zostały wybrane spośród wykładów wygłoszonych podczas trzeciego sympozjum Nitobe, zorganizowanego w ramach Uniwersalnego Kongresu Esperanta w 2004 r. w Pekinie. Analiza nie potwierdziła jednak wniosków poczynionych przez wielu badaczy. Mimo niepowodzenia autor jest pewny, że bardziej odpowiednia metoda i większa próba mogą pokazać, w jaki sposób kultury rodzime wpływają na esperantystów w ich przemówieniach.
Neural Remodeling of the Left Atrium in rats by Rosuvastatin following Acute Myocardial Infarction
Authors: Wang Jiang-Rong , Wang Meng-Zan , Zheng Shao-Hua , Li Zhi-Yuan
Published: January 2020

Objective

This study aims to investigate the effect of rosuvastatin on sympathetic neural remodeling of the left atrium (LA) in rats after myocardial infarction (MI).

Methods

Rats were randomly divided into a three groups: sham group, statin group, and MI group. The mRNA expression levels of the growth-associated protein-43 (GAP43) and nerve growth factor (NGF) were measured by RT-PCR. Immunohistochemistry was used to detect the distribution and density of GAP43- and NGF-positive nerves. The expression levels of these proteins were quantified by Western blot.

Results

Compared with the sham group, the average optical density (AOD) values of GAP43 and nerve growth factor (NGF)-positive substances in the LA in the statin and MI groups were significantly higher (P<0.01), but the AOD values in the statin group were lower than of those in the MI group (P<0.01). Furthermore, the AOD values of GAP43 and NGF positive nerves in the left stellate ganglion in the statin and MI groups were significantly higher (P<0.01), but the AOD values in the statin group were lower, when compared with the MI group (P<0.01).

Conclusion

Rosuvastatin could effectively improve the sympathetic neural remodeling of LA in MI rats.
Treatment of hepatic cystic echinococcosis patients with clear cell renal carcinoma: a case report
Authors: Ran Bo , Cheng Lujin , Kang Lin , Aji Tuerganaili , Jiang Tieming , Zhang Ruiqing , Guo Qiang , Wen Hao , Shao Yingmei , Xiao Hui
Published: January 2020

Human cystic echinococcosis is a zoonosis caused by the larval cestode Echinococcus granulosus. Clear cell renal carcinoma is the most common pathological type of renal cell carcinoma. Echinococcosis complicated with carcinoma is rarely reported. Here, we reported a female patient with echinococcal cyst of the liver accompanied with clear cell renal carcinoma. This 27-year-old woman was admitted for abdominal pain. The serological testing of hydatid cyst was positive and levels of tumor markers were within the normal range. The computed tomography and histological findings confirmed hepatic echinococcal cyst complicated with renal carcinoma of kidney. Preoperative liver function was grade A. The patient underwent pericystectomy of liver hydatid cyst and partial nephrectomy. No recurrence was found at 1 year of follow-up. Liver hydatid complicated with renal cell carcinoma is rare, which should be differentiated from liver metastasis of renal cancer. Surgical resection is the optimal treatment. This case may provide insight for the diagnosis and research on the co-occurrence of tumor and hydatid cyst.
The influence of hypoxia on the prostate cancer proteome
Authors: Ross James A. , Vissers Johannes P.C. , Nanda Jyoti , Stewart Grant D. , Husi Holger , Habib Fouad K. , Hammond Dean E. , Gethings Lee A.
Published: January 2020

Prostate cancer accounts for around 15% of male deaths in Western Europe and is the second leading cause of cancer death in men after lung cancer. Mounting evidence suggests that prostate cancer deposits exist within a hypoxic environment and this contributes to radio-resistance thus hampering one of the major therapies for this cancer. Recent reports have shown that nitric oxide (NO) donating non-steroidal anti-inflammatory drugs (NSAIDs) reduced tumour hypoxia as well as maintaining a radio-sensitising/therapeutic effect on prostate cancer cells. The aim of this study was to evaluate the impact of hypoxia on the proteome of the prostate and to establish whether NO-NSAID treatment reverted the protein profiles back to their normoxic status. To this end an established hormone insensitive prostate cancer cell line, PC-3, was cultured under hypoxic and normoxic conditions before and following exposure to NO-NSAID in combination with selected other common prostate cancer treatment types. The extracted proteins were analysed by ion mobility-assisted data independent acquisition mass spectrometry (MS), combined with multivariate statistical analyses, to measure hypoxia-induced alterations in the proteome of these cells. The analyses demonstrated that under hypoxic conditions there were well-defined, significantly regulated/differentially expressed proteins primarily involved with structural and binding processes including, for example, TUBB4A, CIRP and PLOD1. Additionally, the exposure of hypoxic cells to NSAID and NO-NSAID agents, resulted in some of these proteins being differentially expressed; for example, both PCNA and HNRNPA1L were down-regulated, corresponding with disruption in the nucleocytoplasmic shuttling process.
The Blum-Hanson Property
Authors: Grivaux Sophie
Published: January 2020

Given a (real or complex, separable) Banach space, and a contraction T on X, we say that T has the Blum-Hanson property if whenever x, y ∈ X are such that Tnx tends weakly to y in X as n tends to infinity, the means

{1 \over N}\sum\limits_{k = 1}^N {{T^{{n_k}}}x}

tend to y in norm for every strictly increasing sequence (nk) k≥1 of integers. The space X itself has the Blum-Hanson property if every contraction on X has the Blum-Hanson property. We explain the ergodic-theoretic motivation for the Blum-Hanson property, prove that Hilbert spaces have the Blum-Hanson property, and then present a recent criterion of a geometric flavor, due to Lefèvre-Matheron-Primot, which allows to retrieve essentially all the known examples of spaces with the Blum-Hanson property. Lastly, following Lefèvre-Matheron, we characterize the compact metric spaces K such that the space C(K) has the Blum-Hanson property.
Anti-termite and anti-fungal bio-sourced wood preservation ingredients from Dacryodes edulis (G. Don) H.J. Lam resin
Authors: Bédounguindzi Walter Fiacre , Candelier Kévin , Edou Engonga Prosper , Dumarçay Stéphane , Thévenon Marie-France , Gérardin Philippe
Published: January 2020

Dacryodes edulis (G. Don) H.J. Lam resin was hydro-distilled to recover essential oil (EO), and further purified to produce a heavy fraction constituting less volatile compounds. Chemical composition was investigated by gas chromatography-mass spectrometry (GC-MS), and indicated that different monoterpenes and triterpenes were present depending on the analyzed fraction. Bioassays were performed on the different fractions to evaluate their anti-fungal and anti-termite properties. Results indicated that crude resin, its heavy fraction and its EO all had proved termicidal properties, which decrease on drying for EO and crude resin due to evaporation of monoterpenes. Conversely, no anti-fungal properties were observed for any fraction. Dacryodes edulis resin is therefore a new valuable bioactive ingredient for the formulation of wood protection products with anti-termite properties.
Discrimination of Volatiles of Shiitakes (Lentinula edodes) Produced during Drying Process by Electronic Nose
Authors: Zhang Hui , Peng Jing , Zhang Yu-ren , Liu Qiang , Pan Lei-qing , Tu Kang
Published: January 2020

This study aimed to investigate the potential of electronic nose (E-nose) to differentiate volatiles of shiitakes produced at different drying stages. Shiitakes at different drying time slots were categorized into four groups (fresh, early, middle and late stage) by sensory evaluation. E-nose was used to analyze the volatiles and compared with headspace solid phase micro-extraction combined with gas chromatography-mass spectrometry (HS/GC-MS). The principal component analysis results showed that shiitakes at each stage could be successfully discriminated by E-nose and HS/GC-MS. The differences in volatile organic compounds produced at each stage were mainly caused by sulfurs and alcohols, leading to apparent changes of sensors sensitive to sulfurs, alcohols and aromatic compounds. The discriminant models were established by partial least squares discriminant analysis and support vector machine classification, with accuracy rates of 91.25 % and 95.83 %, respectively. The results demonstrated the potential use of E-nose in classifying and monitoring shiitakes during drying process.
Islamic Social Finance in Bangladesh: Challenges and Opportunities of the Institutional and Regulatory Landscape
Authors: Uddin Tanvir Ahmed , Mohiuddin Md Fazla
Published: January 2020

From the end of World War Two, the core methodology of law and development projects has been to transplant the best legal institutions of Western capitalism to poor and emerging economies. In many post-colonial contemporary Muslim-majority countries, such programs have not adequately engaged with local legal systems, cultures and traditions. Contrary to the restrictive modernist approach to law and development, and inspired by the Sharia, there are numerous Islamic social finance mechanisms that can be utilised for poverty alleviation and their existence is evident across Bangladesh. These cover the full spectrum of philanthropic to financing, investments and insurance built upon Sharia norms and principles. Unfortunately, the true potential of Islamic social finance is considerably constrained by the weak regulatory and policy environment. Islamic social finance does not feature in national development plans, is regulated through a patchwork framework, and operates at a negligible scale. This paper provides a detailed analysis of the existing regulatory and institutional landscape of Zakah (obligatory almsgiving), awqaf (perpetual endowments), Islamic microfinance and microtakaful (microinsurance) in Bangladesh and examines the potential and challenges for Islamic social finance to reduce poverty. Thereafter, several pertinent policy and institutional recommendations are provided to effectively modernise and advance the effectiveness of Islamic social finance institutions. The methodology employed is a mixed approach incorporating literature review, legal analysis of laws and regulation and contextual analysis and field interviews among industry stakeholders. Ultimately, while private investment and initiatives are always able to support the Islamic social finance sector, this paper focuses on the extent to which the regulatory and policy environment is a crucial enabler for widespread and sustained development impact.
Ordering biases in cross-linguistic perspective: The interaction of serial order and structural level
Authors: Berg Thomas
Published: January 2020

Capitalizing upon the typological fact that the same content may be coded in different positions and at different structural levels, this study examines whether the syntactic and the morphological levels exhibit different serial-order preferences. A large-scale comparison of word and morpheme order across six grammatical categories including definiteness and negation reveals that all six categories document the same interaction effect: the syntactic level shows a significantly higher preposing rate than the morphological level does. A morphological postposing bias is observed for five categories, a syntactic preposing bias for four and a syntactic postposing bias for two. This interaction effect is not affected by a genealogical or areal bias. The empirical patterns are mainly shaped by a predilection for lexical material to precede grammatical material. Early placement may also be brought about by ultra-high token frequency. The fact that the postposing bias does occur sporadically at the syntactic level casts some doubt on the well-known suffixing preference as the appropriate level of generalization.
Mono-crystalline gold platelets: a high-quality platform for surface plasmon polaritons
Authors: Kaltenecker Korbinian J. , Krauss Enno , Casses Laura , Geisler Mathias , Hecht Bert , Mortensen N. Asger , Jepsen Peter Uhd , Stenger Nicolas
Published: January 2020

We use mono-crystalline gold platelets with ultra-smooth surfaces and superior plasmonic properties to investigate the formation of interference patterns caused by surface plasmon polaritons (SPPs) with scattering-type scanning near-field microscopy at 521 and 633 nm. By applying a Fourier analysis approach, we can identify and separate several signal channels related to SPPs launched and scattered by the atomic force microscopy tip and the edges of the platelet. Especially at the excitation wavelength of 633 nm, we can isolate a region in the center of the platelets where we find only contributions of SPPs which are launched by the tip and reflected at the edges. These signatures are used to determine the SPP wavelength of λ
SPP = 606 nm in good agreement with theoretical predictions. Furthermore, we were still able to measure SPP signals after 20 µm propagation, which demonstrates impressively the superior plasmonic quality of these mono-crystalline gold platelets.
III-nitride photonic cavities
Authors: Butté Raphaël , Grandjean Nicolas
Published: January 2020

Owing to their wide direct bandgap tunability, III-nitride (III-N) compound semiconductors have been proven instrumental in the development of blue light-emitting diodes that led to the so-called solid-state lighting revolution and blue laser diodes that are used for optical data storage. Beyond such conventional optoelectronic devices, in this review, we explore the progress made in the past 15 years with this low refractive index material family for the realization of microdisks as well as 2D and 1D photonic crystal (PhC) membrane cavities. Critical aspects related to their design and fabrication are first highlighted. Then, the optical properties of passive PhC structures designed for near-infrared such as their quality factor and their mode volume are addressed. Additional challenges dealing with fabrication pertaining to structures designed for shorter wavelengths, namely the visible to ultraviolet spectral range, are also critically reviewed and analyzed. Various applications ranging from second and third harmonic generation to microlasers and nanolasers are then discussed. Finally, forthcoming challenges and novel fields of application of III-N photonic cavities are commented.
A Big Data Analysis Method Based on Modified Collaborative Filtering Recommendation Algorithms
Authors: Yin Nan
Published: January 2020

With the rapid development of e-commerce, collaborative filtering recommendation system has been widely used in various network platforms. Using recommendation system to accurately predict customers’ preferences for goods can solve the problem of information overload faced by users and improve users’ dependence on the network platform. Because the recommendation system based on collaborative filtering technology has the ability to recommend more abstract or difficult to describe goods in words, the research related to collaborative filtering technology has attracted more and more attention. According to the past research, in collaborative filtering algorithm, if Pearson correlation coefficient is used, errors will occur under special circumstances. In this study, the normal recovery similarity measure is used to modify the similarity value to correct the error value of a collaborative filtering recommendation algorithm. Based on this, a big data analysis method based on a modified collaborative filtering recommendation algorithm is proposed. This research implemented it in the cloud Hadoop environment, and measure the execution time with 2, 5 and 8 nodes. Then the research compared it with the execution time of a single machine, and analyze its speedup ratio and efficiency. The experimental results show that the execution time increases with the number of neighbors. When the number of nodes is 5 and 8, the execution time is greatly improved, which improves the efficiency of collaborative filtering algorithm and can cope with massive data in the future.
The Influence of Trading Volume, Market Trend, and Monetary Policy on Characteristics of the Chinese Stock Exchange: An Econophysics Perspective
Authors: Ran Meng , Tang Zhenpeng , Chen Weihong
Published: January 2020

The paper adopts the financial physics approach to investigate influence of trading volume, market trend, as well as monetary policy on characteristics of the Chinese Stock Exchange. Utilizing 1-minute high-frequency data at various time intervals, the study examines the probability distribution density, autocorrelation and multi-fractal of the Shanghai Composite Index. Our study finds that the scale of trading volume, stock market trends, and monetary policy cycles all exert significant influences on micro characteristics of Shanghai Composite Index. More specifically, under the conditions of large trading volumes, loose monetary policies, and downward stock trends, the market possesses better fitting on Levy’s distribution, the volatility self-correlation is stronger, and multifractal trait is more salient. We hope our study could provide better guidance for investment decisions, and form the basis for policy formulation aiming for a healthy growth of the financial market.
How Culture Moderates the Effects of Justice in Service Recovery
Authors: Chebat Elise , Roth Yefim , Chebat Jean Charles
Published: January 2020

This article strives to clarify the importance and the effects of cultural differences on consumer satisfaction after a service failure in an individualistic society (Canada) vs. a collectivistic society (Japan). We focus on young, educated consumers to analyze if the contrasts shown in the extant literature between these two cultures are still relevant in the case of young consumers of both cultures when confronted with a service failure and service recovery. We used 150 questionnaires from Japan and Canada, the design of which reflects our theoretical model. Respondents were asked to recall one of their own negative service experience and the service recovery that may have followed. Our statistical analysis is based on Hayes’s PROCESS that allows to test complex moderated and mediated relations. We find that Anger mediates the relation between failure severity and consumer behavioral responses (EXIT and NWOM) similarly for both Japanese and Canadian consumers. Importantly, compensation, involving procedural and distributive justice (i. e. time – speedy service recovery and money) both reduced consumer anger, more so for individualistic consumers. Surprisingly, interactional justice (e. g. courteousness, politeness, and signs of respect) had no impact on neither individualistic nor collectivistic consumers. Our findings suggest that service providers should first fix the negative emotional reactions as a result of service failure. They may reduce this emotional reaction offering monetary compensation to both Individualistic and Collectivistic consumers. Younger collectivistic consumers are not more sensitive to signs of respect and politeness than individualistic consumers, which may show that the younger generation of Japanese consumers is getting closer to the individualistic culture.
Development of a serum free medium for HUMIRA® biosimilar by design of experiment approaches
Authors: Kimiz-Gebologlu Ilgin , Saglam-Metiner Pelin , Ozaslan Oznur , Ayyildiz-Tamis Duygu , Deliloglu-Gurhan Saime Ismet , Gulce-Iz Sultan
Published: January 2020

Background

Serum have been traditionally used to support growth of animal cell cultures. However, the increasing growth of therapeutic biopharmaceuticals market, accelerated the high demand for the serum-free medium (SFM).

Objective

The main objective is to design a SFM for a stable rCHO cell line that produces a fully anti-human TNF-α monoclonal antibody (mAb) corresponding to HUMIRA® biosimilar.

Materials and methods

Design of Experiment (DoE) approaches were used to determine the key factors due to their effect on specific growth rate and mAb production. The production was carried out in T-flasks at different initial cell concentrations and then in Erlenmeyers with the developed SFM. mAb production was compared with commercial SFMs in terms of yield and productivity.

Results

Regarding to our findings, when the developed SFM-adapted cells were compared with the cells produced in commercial SFMs, the mAb productivity in developed SFM were higher (1.3–1.6 times) depending on higher mAb concentration and less (3–5 times) cell concentration. Additionally, the produced mAb in the developed SFM provided high conformational similarity with its originator HUMIRA®.

Conclusion

DoE approaches could be used to reduce cost and time in designing SFM for any commercially important cell line to produce high value biologics.
Gilbert Ryle and the Ethical Impetus for Know-How
Authors: Dougherty Matt
Published: January 2020

This paper aims to shed light on an underexplored aspect of Gilbert Ryle’s interest in the notion of “knowing-how”. It is argued that in addition to his motive of discounting a certain theory of mind, his interest in the notion also stemmed (and perhaps stemmed more deeply) from two ethical interests: one concerning his own life as a philosopher and whether the philosopher has any meaningful task, and one concerning the ancient issue of whether virtue is a kind of knowledge. It is argued that Ryle saw know-how as crucial in both respects and, also, that he continued to be interested in these ethical issues throughout his career.
BIOGENIC AMINE PRODUCTION IN HISTIDINE DECARBOXYLASE BROTH BY SELECTED LACTIC ACID BACTERIA STRAINS
Authors: YAZGAN Hatice
Published: January 2020

The purpose of the current study
was to investigate the biogenic amine production of lactic acid bacteria (LAB)
strains (Lactobacillus pentosus, Lactobacillus plantarum, Pediococcus
acidilactici, Lactobacillus paraplantarum, Lactobacillus
fermentum, Lactococcus raffinolactis, Pediococcus pentosaceus and
Leuconostoc mesenteroides) which in fermented foodstuff. Biogenic amine
production of LAB strains was monitored in histidine decarboxylase broth using
HPLC method. Significant differences were observed on ammonia (AMN) and
biogenic amines accumulation among LAB strains (p<0.05). Although P.
acidilactici produced lesser AMN than other LAB, it was observed that all
LAB strains produced high amount of AMN. LAB strains produced all amines in
amounts between 1.48 and 1187.50 mg/L. Histamine production by LAB was in range
from 17.20 mg/L by P. acidilactici to 126.26 mg/L by Lb. fermentum.
The lowest tyramine concentration was observed by P. acidilactici with
value of 14.66 mg/L whilst the highest tyramine production was found by L.
raffinolactis with value of 64.43 mg/L.