bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultivating Resilience: Promoting Investment in Alternative Agricultural Products for Enhanced Food Security in Kenya
Authors: Muthike Wairimu , Schmidt Mario , Muriithi Mugambi
Published: April 2024

This position paper explores the importance of promoting investment in alternative agricultural products in Kenya to enhance food security and foster a resilient food system. The paper analyzes the current state of maize production and consumption in Kenya, compares it to neighboring countries, and delves into the challenges and inefficiencies of maize cultivation and transforming household diets. By examining comparable crops within Kenya and East Africa, it highlights potential solutions to the issues plaguing maize production and consumption. The dietary diversity of Kenyan households and its changes over time are investigated to identify underlying causes, and the unchanging demand for calorie-dense foods like maize is scrutinized. The paper proposes a paradigm shift towards a diversified food system and assesses past structural and behavioral interventions, identifying gaps that require attention.
Cierre primario de fisura labial unilateral. Reporte de casos
Authors: López Tamara Mercedes
Published: April 2024

La fisura labial, malformación congénita común, que afecta a estructuras faciales y cavidad oral, requiere manejo multidisciplinario. El cirujano especialista es relevante por la variedad de procedimientos quirúrgicos que el paciente requiere, en la reparación de las anomalías. Objetivo: Reportar las técnicas quirúrgicas realizadas, en el cierre primario de cinco pacientes con labio fisurado unilateral, según protocolo quirúrgico sistemático utilizado. Material y Método: Estudio descriptivo, de 5 casos, con enfoque cualitativo, y de corte transversal. Se describen los procedimientos quirúrgicos en cinco pacientes pediátricos, menores de 12 meses, diagnosticados con fisuras labiales unilaterales, operados durante el año 2022, usando la técnica de Fisher y la reconstrucción nasal para el cierre primario. Los cinco pacientes fueron evaluados de forma individual según el índice de severidad inicial. Resultados: Se muestra el postoperatorio inmediato de cinco pacientes con fisuras labiales unilaterales, no sindrómica, a quienes se les realizó técnica quirúrgica para el cierre primario, basándose en las subunidades anatómicos del labio y nariz, descritas por Fisher, desde el año 2004, lo que permitió minimizar la visibilidad de las cicatrices postoperatorias, siendo fundamental para obtener resultados estéticos satisfactorios. Conclusiones: Para el cierre primario satisfactorio en pacientes con fisura labial unilateral se recomienda la técnica de Fisher por sus principales ventajas, en combinación con la reconstrucción primaria del piso nasal y el cierre de la fisura alveolar, procedimientos quirúrgicos recomendables para lograr resultados satisfactorios en el postoperatorio inmediato.
Evaluación de la aplicación de tres insecticidas botánicos sobre poblaciones de Typophorus nigritus
Authors: Vuelta Lorenzo Daniel Rafael , Rizo Mustelier Miriela
Published: April 2024

The experimental work was carried out at the UBPC ¨Paquito Borrero Lavadí¨ located in the municipality of Palma Soriano in the Santiago de Cuba province. This experiment was carried out with 4 treatments and 5 replications, 3 treatments with the application of botanicals insecticides (Adelfa, Cardona and Tabaquina) and a control in a brown soil without carbonate. Counting on an experimental area of 13,400 m2, divided into 16 plots of 558 m2 in area. The proposed objective was to evaluate the efficiency of three natural insecticides on Typophorus nigritus populations in sweet potato crop. It was found that the Cardona application turned out to be the best followed by the Tabaquina applications with the best values of technical efficiency and of the indicators of the development and yield of the crops.
Characterization Of First Metatarsal Regeneration After New Modern Minimally Invasive Bunion Surgery. A Retrospective Radiographic Review Of 172 Cases.
Authors: Blitz Neal M , Wong David T , Grecea Bogdan , Baskin Eric
Published: April 2024

Introduction First metatarsal regeneration (FMR) is a new phenomenon that occurs as a result of new minimally invasive bunion surgery (MIBS) and has yet to be studied. The goal of this investigation is to characterize bone healing and introduce a new classification system (3 Types).

Methods A retrospective radiographic review between January 2018 to June 2021 was performed, identifying 172 feet (122 patients). A minimum of four months of follow-up was required to be included. We classified the extent of callus formation based on the relationship to the primary “anchor” screw. A FMR Type I involved callus medial to the screw, FMR Type II involved callus medial and lateral to the screw, and FMR Type III had robust callus with first metatarsal regeneration.

Results Mean age was 46.6±14.6 years; 117 (95.9%) females and 5 (4.1%) males. Mean follow-up was 8.2±5.7 months. The FMR bone healing distributions were Type I (17.4%, 30 feet), Type II (42.4%, 73 feet), and Type III (40.1%, 69 feet). There was a statistically significant overall difference in both IM and HVA, (P<0.001), which was maintained across all FMR types (I-III, p<0.0001 for all comparisons). No statistical significant correlation between FMR type and age, sex, laterality, operation on both or one foot, length of follow-up, and pre- and postop radiographic angles. The same FMR type occurred in bilateral surgery in 28% when performed on the same day, and 20% on different days; and these differences were not statistically significant.

Conclusion This is the first investigation to provide patterns of healing after MIBS, and evidence that FMR does occur for all bunion severities. Surgeons considering performing MIBS should no longer fear that bone healing is not possible. Our classification will help guide future studies by comparing the FMR with different techniques, fixation types/constructs and/or weight bearing protocols.
Anthropometric measurements of male and female workers in bipedestation in the Venezuelan industrial direct labor force
Authors: Labrador Parra Alejandro , Escalona Evelin , Meyer Felipe
Published: April 2024

In the Venezuelan labor context, there is scarce information associated with anthropometric measurements, due to the existing gaps in the field of ergonomics in Latin America and the Caribbean, of which there are few professionals trained in ergonomics. In this sense, it has affected the proper achievement of anthropometric studies that allow an adequate follow-up in the population in general and more specifically in the labor world. General objective: to measure and determine the anthropometric variables in standing position of Venezuelan workers in order to obtain more results in the field of occupational health. Methods: A quantitative, descriptive, cross-sectional, epidemiological and field study was carried out in a Venezuelan population of industrial direct labor workers in standing. The sample consisted of 185 workers (M:131, W:54) in the main industrial areas of the state of Aragua-Venezuela. The measuring instruments used in the investigation were: anthropometric tables for standing measurements, flexible tape measure for perimeter measurements and a wall height meter with a scale for weight measurements. The minitab-17 statistical package was used for the analysis and statistical study. Results: The study group consisted of 185 workers with an age range between 20-59 years; 131 men (70.8%) and 54 women (29.2%). The people evaluated had an average age of 43 years, their height x: 170.08 m, they are workers with 10 to 15 years of work experience, with wear and tear and possible pre-existing diseases, likewise, the female workers have an age x: 40.33 years and their height x: 156.27 cm, as well as the male worker have an average work experience between 10 and 15 years and possible pre-existing diseases. Conclusion: The study provides an approximation of anthropometric measurements in standing position of Venezuelan industrial direct labor workers (MODIV), which will allow the adaptation of workstations
Demanda energética del transporte urbano para la electromovilidad pública de la Amazonía ecuatoriana [Urban transport energy demand for public electromobility in the Ecuadorian Amazon]
Authors: Ledesma-Acosta Rubén Darío , Guilcamaigua-Tarco Miguel Ángel , Garay-Montaño Jenny Paola
Published: April 2024

El objetivo de este estudio es calcular la demanda energética de un bus de trasporte público del catón Pastaza en una ruta de mayor recorrido para consideración de proyectos de electromovilidad en el cantón Pastaza. Se realizó 32 ensayos durante el recorrido real de una ruta del servicio de transporte público en una distancia de 22.23 [km], determinando la altitud positiva acumulativa, el ciclo típico y el consumo energético mediante el calculando de: Resistencia a la rodadura [E.Rx], Fuerza de arrastre [E.Fd], Resistencia debido a la pendiente [E.Rg], Resistencia debido a la inercia [E.R ] y Energía ganadas [E+]. Las altitudes positivas acumulativas en los tres días de ensayo fueron 297.97 [m], 293.83 [m] y 272.40 [m] respectivamente; la demanda energética de la ruta de estudio en función al ciclo típico fue determinada en el ensayo 26 donde su demanda energética fue de 224.18 [kwh].
Deduplication of error reports in software malfunction: Algorithms for comparing call stacks
Authors: Pavlenko Serhii , Kuliabko Petro
Published: April 2024

In the software industry, the standard recognises automatic fault monitoring systems as mandatory for implementation. Considering the constant development of technologies and the high complexity of programmes, the importance of optimising processes for detecting and eliminating errors becomes a relevant task due to the need for reliability and stability of software. The purpose of this study is to conduct a detailed analysis of existing deduplication algorithms for reports from automatic systems collecting information about software failures. Among the algorithms considered were: the longest common subsequence method, Levenshtein distance, deep learning methods, Siamese neural networks, and hidden Markov models. The results obtained indicate a great potential for optimising processes of error detection and elimination in software. The developed comprehensive approach to the analysis and detection of duplicates in call stacks in failure reports allows for effectively addressing issues. The deep learning methods and hidden Markov models have demonstrated their effectiveness and feasibility for real-world applications. Effective methods for comparing key parameters of reports are identified, which contributes to the identification and grouping of recurring errors. The use of call stack comparison algorithms has proven critical for accurately identifying similar error cases in products with large audiences and high parallelism conditions. Siamese neural networks and the Scream Tracker 3 Module algorithm are used to determine the similarity of call stacks, including the application of recurrent neural networks (long short-term memory, bidirectional long short-term memory). Optimisation of report processing and clustering particularly enhances the speed and efficiency of responding to new failure cases, allowing developers to improve system stability and focus on high-priority issues. The study is useful for software developers, software development companies, system administrators, research groups, algorithm and tool development companies, cybersecurity professionals, and educational institutions
加快建设数字广东，促进广东高质量发展
Authors: Lu Hanbin , Xu Yuyang
Published: April 2024

数字广东是指大力推进广东全省政务、商务、生产、生活等领域的信息化，促进信息产业、信息技术、信息资源和信息环境全面发展，将广东建成面向全世界、服务全国的信息区域中心。没有数字广东建设,就不可能有广东的高质量发展。因此,广东要认真学习习近平总书记关于数字经济与高质量发展的重要论述;建立健全广东高质量发展工作推进机制;建立广东数据交易机构和提高数字经济效益;精准建设数字广东总库和各类分库;全方位吸纳和培养数字广东建设的紧缺人才;深入推进数字广东法治建设和切实保障数据安全;始终坚持党对数字广东建设与高质量发展的全面领导等。
媒体宣传工作与中国共产党形象建设——基于习近平文化思想的思考
Authors: Wang Bingrong
Published: April 2024

随着全国宣传思想文化工作会议的召开，习近平总书记对宣传思想文化工作做出“七个着力”重要指示并首次提出习近平文化思想，我们从中提炼出一个重要的载体——媒体宣传。从前期的党报、电台广播到后来的政府机关报、新闻传媒网络，再到如今的线上学习平台、公众号、广播甚至是影视节目，无不体现着我们党在建设党外党内、国内国际形象时，创造性地将中国革命、建设、改革、发展的实际与媒体宣传工作紧密结合。在理论逻辑、实践逻辑、历史逻辑三个层面体现“两个结合”，深化推进新时代中国特色社会主义思想并致力于实现中国式现代化奋斗目标。
Enhancing Adaptive Video Streaming Through AI-Driven Predictive Analytics for Network Conditions: A Comprehensive Review
Authors: Khan Koffa
Published: April 2024

As the demand for high-quality video streaming continues to surge, the adaptability of streaming systems to dynamic and unpredictable network conditions becomes paramount. This review paper delves into the realm of adaptive video streaming, focusing on the integration of AI-driven predictive analytics to anticipate and optimize network conditions. The paper provides an extensive overview of existing adaptive streaming algorithms, highlighting the challenges posed by fluctuating network conditions. It explores the role of predictive analytics in mitigating these challenges, emphasizing the use of machine learning models and AI technologies. Through case studies and discussions on real-world implementations, the paper showcases how predictive analytics enhances the decision-making process in adaptive streaming systems, leading to improved bitrate adaptation and content delivery. Challenges and limitations associated with predictive analytics are scrutinized, paving the way for a comprehensive understanding of its implications. The integration of predictive analytics into adaptive streaming systems is examined, emphasizing its potential to revolutionize the quality of service. Finally, the paper outlines future trends and research directions, offering insights into the evolving landscape of adaptive video streaming. This review consolidates knowledge and provides a valuable resource for researchers, practitioners, and industry professionals involved in the intersection of video streaming, predictive analytics, and artificial intelligence.
Model Dukungan Holistik terhadap Pendidikan Anak di Pondok Pesantren
Authors: Damayanti Dimas Pahlawanita
Published: April 2024

This study aims to assess the significance of parental support within the context of Islamic boarding schools (pondok pesantren) and explore various models of support that can be applied. The research approach employed in this study is a comprehensive review of existing literature (Library Research). The findings of this study indicate the pivotal role of parental support within the pondok pesantren environment in facilitating the development of the students (santri). In this regard, several models of support can be implemented, including emotional, social, economic, and participatory support. Each model of support plays a distinct role in aiding santri to achieve improved academic performance and promote positive personal development. The impact of parental support on santri is highly significant, with students who receive adequate support tending to have higher levels of happiness and stronger motivation for learning. This support also helps santri overcome various challenges and obstacles that may arise during their stay in the pesantren. Furthermore, the importance of open communication between parents and santri within the pesantren cannot be understated. Such communication contributes to the creation of an environment that supports the holistic development of santri. Effective communication allows parents to better understand the needs of their children and helps santri feel more comfortable in the pesantren environment.
Pengembangan Perangkat Pembelajaran Model Cooperative Tipe Two Stay Two Stray Berbasis Tradisi Upacara Benyaru untuk Meningkatkan Kompetensi Peserta
Authors: Hidayati Yuni Nur , Warsono Warsono , Basuki Ismet
Published: April 2024

This research aims to develop learning tools using the Two Stay Two Stray Cooperative Model Based on the Benyaru Ceremony Tradition to Improve Participants' Competence. This study uses a development design adopted from 4D design, namely Define, Design, Develop and Disseminate. The results of the development show that the progress achieved on the LKS instrument has produced teaching materials and lesson plans that meet the criteria. valid and can be used as a learning tool. The results of the research attitude competency test show an increase in learning outcomes at SMPN 1 Long Ikis (which is used as an exam school) as well as at SMPN 2 Long Ikis and SMPN 5 Long Ikis. The knowledge competency research shows better learning outcomes both at SMPN 1 Long Ikis, as well as at SMPN 2 Long Ikis and SMPN 5 Long Ikis, this supports this. This is clear because the attitude scores and learning outcomes have exceeded the KKM. Based on the attitude competency test, learning outcomes have increased at SMPN 1 Long Ikis (which was used as a trial school) as well as at SMPN 2 Long Ikis and SMPN 5 Long Ikis.
Pengembangan Media Pembelajaran Berbasis Aplikasi Android dalam Pembelajaran CNC di Kelas XII Teknik Pemesinan
Authors: Abdillah Ahmad Haris , Atiqoh Atiqoh , Karyono Hari
Published: April 2024

This research aims to develop effective and interactive Android application-based learning media for learning CNC (Computer Numerical Control) in class XII Machining Engineering. This research uses the ADDIE development method which involves preliminary studies, learning media development, and data obtained from validation results from media experts 78.00%, material experts 92.22% and design experts 95.00% and three trials were carried out on students, namely individual trials obtained percentages 90.55%, small group trials obtained a percentage of 90.27% and field trials obtained a percentage of 93.43% with very good criteria. The conclusion of this research shows that the development of Android application-based learning media in CNC learning has very good quality and is suitable for use in the learning process, can foster student learning motivation, the Android application developed is very interesting and easy to use as well as innovative and effective in helping students in CNC subjects in class XII Machining Engineering, Android applications can improve students' theoretical and practical skills in CNC subjects in class XII Machining Engineering.
Improving English Reading Comprehension Skills Through SQ4R Method
Authors: Lus Firdaus Zakiya
Published: April 2024

This study aims to obtain data on the improvement of English reading comprehension skills through the SQ4R method for third grade students of MI Miftahus Sholah Mojokerto. The research subjects were third grade students in semester II of the 2022/2023 school year. This research was conducted using the Kemmis and Mc. Taggart model which was carried out with the stages of planning, implementation, observation, and reflection. The results of the research using the SQ4R method showed data obtained from the reading comprehension evaluation test of students who scored ≥ 75 in cycle I 55.55% and in cycle II obtained 83.33%. While monitoring teacher and student activities in cycle I the first meeting was 55% and the second meeting was 70%, while cycle II the first meeting was 85% and the second meeting was 90%. Thus reading comprehension with the SQ4R method can improve the reading comprehension skills of grade III students of MI Miftahus Sholah Mojokerto.
Kontribusi Kegiatan Bahtsul Masail dalam Meningkatkan Kemampuan Memahami Kitab Kuning dan Berfikir Kritis Santri di Forum Musyawarah Anjang Sana Anjang Sini (FMAA) di Kabupaten Jember
Authors: Helmi Achmad Mahrus , Hanifuddin Hanifuddin
Published: April 2024

This research aims to determine: (1) Implementation of bahtsul masail activities in FMAA activities (2) Contribution of FMAA activities in increasing students' understanding of the yellow book. (3) Contribution of FMAA activities in improving Santri's critical thinking. (4) Supporting and inhibiting factors for FMAA's contribution to increasing students' understanding of the yellow book and students' critical thinking. The method used is field research with a qualitative approach and the type of research is case study. Data collection uses interview, observation and documentation methods. The data analysis techniques used are: data reduction, data presentation, and drawing conclusions. The results of the research show that bahtsul masail activities in the Anjang Sanjang Here (FMAA) deliberative forum can contribute to increasing the understanding of Santri in understanding the Yellow Book and thinking critically.
Paradigma Mendidik dan Mengajarkan English For Specific Purpose dalam Meningkatkan Kompetensi Mahasiswa Akuntansi Ditinjau dari Perspektif Psikologi Pendidikan
Authors: Marlina Reni , Saefullah Selvia , Nuraeni Iin Indra , Mulyanto Agus , Sumantri Suryana
Published: April 2024

In the field of education, the teaching paradigm means providing lessons about various sciences to individuals, which then will benefit the individual's thinking abilities. Educational Psychology is a branch of psychology that specializes in the understanding of learning and teaching processes in educational environments. Through the perspective of Educational Psychology, education can be viewed as a practical science that seeks to explain learning in accordance with scientifically established principles and facts surrounding human behavior. The research method used was descriptive qualitative with triangulation techniques, data collection through observation, interviews and questionnaires, as well as documentation studies. The results of this research are first, the presence of psychology in the world of education provides practical benefits in the teaching and learning process, especially in learning English For Specific Purposes (ESP) in Accounting courses, which helps students know English terms in making financial reports and journals. Second, it was found that the paradigm skills of teaching and educating ESP when viewed from educational psychology had a positive impact on college graduates and teaching staff. One of them is helping graduates have ESP competence in their field. It is hoped that the results of this research can contribute to the development of the ESP curriculum in Indonesia.
Survei Program Kegiatan Mitigasi Bencana di Lembaga PAUD
Authors: Laili Rohmatul , Ningrum Mallevi Agustin
Published: April 2024

Mitigation is a stage that aims to reduce the possibility of negative impacts when a disaster occurs. With disaster mitigation education, it is hoped that the public can understand the threat of disasters that will occur. How high is the level of achievement of disaster mitigation activity programs in PAUD institutions in West Surabaya, District. Benowo. The type of research used in this research is a quantitative survey with a descriptive approach. Data collection in this research took the form of a questionnaire in the form of a Google form. The results of data analysis used a one-sample t-test with right-hand hypothesis testing. Cronbach's Alpha value is Reliability, it is known that Cronbach's Alpha value is 0.874. This value is then compared with the R-Table value, with the N100 value searched for in the distribution of R-Table values ​​at a significance of 5%, an R-Table value of 0.180 is obtained. All variables have valid status because the calculated r-value (corrected Item-Total Correlation) r-table is 0.180. This disaster mitigation activity program can be used as a learning activity program, especially storytelling activities to help children understand disaster events. By providing play activities, children will feel happy and enthusiastic about participating in learning activities.
Efektivitas Sosial Media Marketing Dalam Membangun Brand Institusi Pendidikan: Perspektif Generasi Z
Authors: Manggopa Stefani , Sumenda Carolina , Kainde Anita Lilly Linne , Mandagi Deske
Published: April 2024

This study aims to analyze generation Z's perception of the effectiveness of SMM in building brands in educational institutions, especially universities. Specifically, this study investigates the influence of SMM on four dimensions of brand gestalt, namely storyscape, sensescape, servicescape, and stakeholders. The design of this study is descriptive causal, with primary data collection through a survey of 225 samples of active students of Klabat University. Data analysis was carried out using Structural Equation Modeling (SEM) with the support of SmartPLS statistical program. The results of the analysis show that SMM has a positive and significant influence on brand trust. Furthermore, brand trust has a positive and significant influence on the four dimensions of brand gestalt, namely storyscape, sensescape, servicescape, and stakeholders. The findings provide information about the important role social media plays in building strong brand perceptions.
Manajemen Akademik dan Kualitas Pendidikan: Sebuah Kajian Mendalam Membagun Kepemimpinan
Authors: Basri Hasan , Nurhayuni Nurhayuni , Algusyairi Parisyi , Syaifuddin Muhammad
Published: April 2024

The aim of this research is to conduct an in-depth study of the relationship between academic management and educational quality with a focus on leadership development. The preparation of this work used the literature review method by searching for data via Google Scholar and Sinta using the keyword principal leadership. The five identification steps include interpreting the scope of the topic, identifying relevant sources, reviewing the literature, writing a review, and applying the literature to the study, with data from six articles analyzed qualitatively. The results of the work emphasize a) the importance of visionary academic leadership with the support of leadership theory to formulate educational direction and achieve quality goals. b) The integration of management concepts, academic engagement, and collective collaboration in educational leadership provides inspiration for continuous improvement and educational excellence. c) Academic leaders must be adaptive strategic decision makers, maintain optimal educational quality, and ensure the positive contribution of educational institutions to society. d) The importance of establishing an organizational culture that supports improving the quality of teaching and staff performance in a conducive work environment. e) Facing contemporary challenges, academic leaders need to have a strategic vision, a balance between leadership and management, and the ability to manage resources to respond to the rapid dynamics of the times.
Manfaat Media Kartu Gambar untuk Peningkatan Membaca Permulaan Anak Usia Dini: Studi Kasus TK Kristen Satu Atap Sabron Yaru Kabupaten Jayapura
Authors: Jeujanan Christina Anita , Simanjuntak Ria Imelda
Published: April 2024

This research was conducted at TK Satu Atap Sabron Sari, Kampung Sabron Sari, Sentani Barat District, Jayapura Regency, focusing on the effectiveness of using picture cards as a medium to enhance early reading skills in young children. Established on July 9, 2010, under the auspices of Yayasan Laskar Kristus, this kindergarten offers a conducive and comfortable learning environment, making it a preferred choice for many parents in the area. The study employed an observational method with a two-cycle learning approach. In Cycle I, it was found that the majority of the students were categorized as Not Yet Developed in reading ability. However, in Cycle II, following the implementation of picture cards as a learning medium, there was a significant improvement in reading skills, with an increase in the number of students achieving Developed According to Expectations and Fully Developed categories. These results indicate that the use of picture cards is an effective method to enhance early reading skills. This study underscores the importance of selecting appropriate learning media to support the learning process in early childhood, especially in the context of beginning reading skills.
Kajian Neoropsikology: Strategi Mnemonic Untuk Meningkatkan Kinerja Memori Dalam Pembelajaran di Sekolah Dasar
Authors: Sari Nur Rohmah Nilam , Nursalim Mochamad , Rahmasari Diana
Published: April 2024

Human memory has a large capacity and unlimited capabilities. Humans use memory to store information important for survival. Mnemonics is a strategy to improve memory performance by encoding information with associations between new information and previously learned information in long-term memory. This research uses a qualitative research method, the Systematic Literature Review (SLR) model with the PRISMA approach with stages Identification, Screening, Eligibility, Included. Identification of literature review data was taken from publish or perish, Google Scholar, Researchgate, and ScienceDirect and 141 articles were obtained which were searched based on keywords, then in second selection they were selected based on more sensitive issues and 19 learning articles were obtained using mnemonic strategies. In the 3rd stage of selection, a study was carried out on the methodology and research results by 2 reviewers so that appropriate articles were obtained and in accordance with the SLR protocol. There were 5 relevant articles containing the issue of neuropsychological studies of learning with memory strategies that can be applied to education in elementary schools. From the results of the analysis, it was found that mnemonics are a fun learning approach strategy with a high success rate and are able to strengthen retention in long-term memory. Menmonic also improves memory performance in the part of the brain Pre Frontal Cortex.
Parents’ Involvement in Students’ Home English Literacy Practices with Divers Populations
Authors: Mufidah Imroatul , Retnaningdyah Pratiwi , Mustofa Ali
Published: April 2024

Not only school, but home literacy practices are extremely important in developing language and literacy skills. Using a case study, this research presents the cases of 6 Senior high school students from diverse backgrounds which is chosen because of their wide range of socioeconomic status, single parenting or working parent, parental educational, also their performance in EFL Classroom. Thorough ORIM framework, it is shown that each parent engages to the students’ home literacy practices in different aspects although not all of form of home literacy practices categories fulfilled in engaging students’ home literacy practices. Five factors influenced their English literacy practices. Both internal and external factors are examined. It becomes evident that fostering a holistic approach to literacy development demands concerted action from multiple stakeholders. Encouraging Family Engagement is suggested. Schools suggested to create and sustain family engagement programs aimed at empowering parents and caregivers to actively participate in their children's literacy development
Træk af åndens og sjælens historie 1: Ånden
Authors: Katzenelson Boje
Published: April 2024

Artiklen er den første af fire, som s´øger at trække en linie gennem udviklingen af centrale dele af menneskets psyke fra pattedyrene til fremtidssamfundet. Den indledes med en gennemgang af instinktadfærd hos dyr og dennes skelnen mellem mål og midler i eksploration. Derpå hominidernes udvikling af tobenethed, driftsregulering, kønsspecifik arbejdsdeling og emotionelle bånd i familiedannelsen. Redskabets indtræden hos homo habilis og erectus peger på bevidsthedens opståen. Bevidstheden når endelig sin fulde udfoldelse gennem sproget og samfundsmæssigheden hos homo sapiens sapiens.
Urban planning regulation and rationing of the infrastructure of mass sports in the largest cities
Authors: Vilenskii Michael Yur'evich , Baranova Anna Yur'evna
Published: April 2024

The article examines the system of urban planning regulation and rationing of mass sports facilities in the largest cities of Russia. The lack of an interconnected system of sports facilities with the planning features of the largest city is one of the most important problems considered in the article. Rationing and regulation are the most important tools for the implementation of any infrastructure systems. The purpose of the study is to determine the directions of the necessary transformation of the system of urban planning regulation and rationing of mass sports infrastructure facilities for the largest cities, taking into account their intensive growth and development of agglomeration processes. The evolutionary development of the system of urban planning regulation of sports infrastructure is considered. To analyze modern regulation and rationing, the documentation of twelve major Russian cities (urban planning standards, master plans, rules of land use and development, infrastructure programs) was analyzed. Based on the analysis of normative documents of three stages of the development of the urban planning regulation system: Soviet (1922-1991), post-Soviet (1991-2000), as well as the modern stage (2000-2023), the main trends and aspects inherent in each stage of regulation of sports infrastructure were identified. Their influence on the modern system of urban planning regulation is determined. An assessment of urban planning standards is proposed according to five criteria: standardized types of sports facilities, their spatial levels, the number of indicators, the provision of facilities for the population and territorial accessibility. The rating of the cities was compiled based on the proposed assessment. The main problems of urban planning regulation and standardization of sports infrastructure facilities are identified. Recommendations for improving the urban planning approach to the formation of sports infrastructure facilities for mass sports in the largest cities are proposed.
Multifocus double-helix point spread function microscopy for 3D single particle tracking
Authors: Ma Guang-Peng , Gong Zhen-Quan , Nie Meng-Jiao , Cao Hui-Qun , Qu Jun-Le , Lin Dan-Ying , Yu Bin ,   Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China,   College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
Published: April 2024

Double-helix point spread function (DH-PSF) microscopy can realize three-dimensional single particle tracking (3D SPT) on a nanoscale, and is widely used in life sciences and other fields. However, its imaging depth-of-field (DOF) and localization accuracy are limited, which hinders its application in thick samples in vivo. To address this issue, this paper proposes a z-splitter prism-based multifocus DH-PSF microscopy (ZPMDM) method and system to improve the DOF and localization accuracy of DH-PSF microscopy without scanning. It solves the problem of large DOF detection of 3D SPT in whole living cells. By means of systematic calibration, the average 3D localization accuracies of three channels of ZPMDM are determined to be σL(x, y, z) = (4.4 nm, 4.6 nm, 10.5 nm), σM(x, y, z) = (4.3 nm, 4.2 nm, 8.2 nm), and σR(x, y, z) = (4.8 nm, 4.4 nm, 10.3 nm). And the effective DOF of the system is extended to 6 μm. Furthermore, the ZPMDM system is used to track fluorescent microspheres in a glycerol-water mixture across a large depth-of-field range. The Brownian motion of the fluorescent microspheres in the mixture solution is also investigated. The experimental results demonstrate that the errors between the experimentally obtained diffusion coefficients and the theoretically calculated diffusion coefficients are all within 10%. The reliability of the ZPMDM system in achieving single-particle 3D tracking imaging is verified in this study. The validity of the method is further verified by preliminarily investigating the phagocytosis phenomenon of live macrophages. It is of significance for the development and application of nanoscale 3D SPT. The ZPMDM system is shown in the attached figure.
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Authors: Kilic Ayse , Halu Arda , De Marzio Margherita , Maiorino Enrico , Duvall Melody G , Bruggemann Thayse Regina , Rojas Quintero Joselyn J , Chase Robert , Mirzakhani Hooman , Sungur Ayse Özge , Koepke Janine , Nakano Taiji , Peh Hong Yong , Krishnamoorthy Nandini , Abdulnour Raja-Elie , Georgopoulos Katia , Litonjua Augusto A , Demay Marie , Renz Harald , Levy Bruce D , Weiss Scott T
Published: April 2024

Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do not provide insight into the molecular genetic mechanisms of vitamin D-mediated immunoregulation. Here, we provide evidence for vitamin D regulation of two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, reliably associated with autoimmune and chronic inflammatory diseases. We demonstrate increased vitamin D receptor (Vdr) expression in mouse lung CD4+ Th2 cells, differential expression of Chr17q12-21.1 and Chr17q21.2 genes in Th2 cells based on vitamin D status and identify the IL-2/Stat5 pathway as a target of vitamin D signaling. Vitamin D deficiency caused severe lung inflammation after allergen challenge in mice that was prevented by long-term prenatal vitamin D supplementation. Mechanistically, vitamin D induced the expression of the Ikzf3-encoded protein Aiolos to suppress IL-2 signaling and ameliorate cytokine production in Th2 cells. These translational findings demonstrate mechanisms for the immune protective effect of vitamin D in allergic lung inflammation with a strong molecular genetic link to the regulation of both Chr17q12-21.1 and Chr17q21.2 genes and suggest further functional studies and interventional strategies for long-term prevention of asthma and other autoimmune disorders.
A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria
Authors: Faniyan Tumininu S. , Zhang Xinyi , Morgan Donald A. , Robles Jorge , Bathina Siresha , Brookes Paul S. , Rahmouni Kamal , Perry Rachel J. , Chhabra Kavaljit H.
Published: April 2024

The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all of the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset by an increase in endogenous glucose production to maintain normal energy supply in the body. How the body senses this glucose loss and consequently enhances glucose production is unclear. Using renal
Glut2
knockout mice, we demonstrate that elevated glycosuria activates the hypothalamic-pituitary-adrenal axis, which in turn drives endogenous glucose production. This phenotype was attenuated by selective afferent renal denervation, indicating the involvement of the afferent nerves in promoting the compensatory increase in glucose production. In addition, through plasma proteomics analyses we observed that acute phase proteins - which are usually involved in body’s defense mechanisms against a threat – were the top candidates which were either upregulated or downregulated in renal
Glut2
KO mice. Overall, afferent renal nerves contribute to promoting endogenous glucose production in response to elevated glycosuria and loss of glucose in urine is sensed as a biological threat in mice. These findings may be useful in improving efficiency of drugs like SGLT2 inhibitors that are intended to treat hyperglycemia by enhancing glycosuria, but are met with a compensatory increase in endogenous glucose production.
Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators
Authors: Masala Nicola , Mittag Manuel , Ambrad Giovannetti Eleonora , O’Neil Darik A. , Distler Fabian , Rupprecht Peter , Helmchen Fritjof , Yuste Rafael , Fuhrmann Martin , Beck Heinz , Wenzel Michael , Kelly Tony
Published: April 2024

Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression to specific brain regions, can be conveniently used with any mouse strain of interest without the need for prior crossing with a GECI mouse line and avoids potential hazards due to the chronic expression of GECIs during development. A key requirement for monitoring neuronal activity with an indicator is that the indicator itself minimally affects activity. Here, using common adeno-associated viral (AAV) transduction procedures, we describe spatially confined aberrant Ca
2+
micro-waves slowly travelling through the hippocampus following expression of GCaMP6, GCaMP7 or R-CaMP1.07 driven by the synapsin promoter with AAV-dependent gene transfer, in a titre-dependent fashion. Ca
2+
micro-waves developed in hippocampal CA1 and CA3, but not dentate gyrus (DG) nor neocortex, were typically first observed at 4 weeks after viral transduction, and persisted up to at least 8 weeks. The phenomenon was robust, observed across laboratories with various experimenters and setups. Our results indicate that aberrant hippocampal Ca
2+
micro-waves depend on the promoter and viral titre of the GECI, density of expression as well as the targeted brain region. We used an alternative viral transduction method of GCaMP which avoids this artifact. The results show that commonly used Ca
2+
-indicator AAV transduction procedures can produce artefactual Ca
2+
responses. Our aim is to raise awareness in the field of these artefactual transduction-induced Ca
2+
micro-waves and we provide a potential solution.Impact statement: Common AAV transduction procedures induce artefactual spatially confined Ca
2+
waves in the hippocampus.
FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
Authors: Gao Chenxi , Ge Huaibin , Kuan Shih-Fan , Cai Chunhui , Lu Xinghua , Esni Farzad , Schoen Robert E. , Wang Jing H. , Chu Edward , Hu Jing
Published: April 2024

BRAF
V600E
mutation is a driver mutation in the serrated pathway to colorectal cancers. BRAF
V600E
drives tumorigenesis through constitutive downstream extracellular signal-regulated kinase (ERK) activation, but high-intensity ERK activation can also trigger tumor suppression. Whether and how oncogenic ERK signaling can be intrinsically adjusted to a “just-right” level optimal for tumorigenesis remains undetermined. In this study, we found that FAK (Focal adhesion kinase) expression was reduced in
BRAF
V600E
-mutant adenomas/polyps in mice and patients. In
Vill-Cre;BRAF
V600E/+
;
Fak
fl/fl
mice,
Fak
deletion maximized BRAF
V600E
’s oncogenic activity and increased cecal tumor incidence to 100%. Mechanistically, our results showed that Fak loss, without jeopardizing BRAF
V600E
-induced ERK pathway transcriptional output, reduced EGFR (epidermal growth factor receptor)-dependent ERK phosphorylation. Reduction in ERK phosphorylation resulted in increased mRNA expression and stability of Lgr4, promoting intestinal stemness and cecal tumor formation. Together, our findings show that a “just-right” ERK signaling optimal for
BRAF
V600E
-induced cecal tumor formation can be achieved via Fak loss-mediated downregulation of ERK phosphorylation.
Detection of TurboID fusion proteins by fluorescent streptavidin outcompetes antibody signals and visualises targets not accessible to antibodies
Authors: Odenwald Johanna , Gabiatti Bernardo , Braune Silke , Shen Siqi , Zoltner Martin , Kramer Susanne
Published: April 2024

Immunofluorescence localises proteins via fluorophore-labelled antibodies. However, some proteins evade detection due to antibody-accessibility issues or because they are naturally low abundant or antigen density is reduced by the imaging method. Here, we show that the fusion of the target protein to the biotin ligase TurboID and subsequent detection of biotinylation by fluorescent streptavidin offers an ‘all in one’ solution to these restrictions. For all proteins tested, the streptavidin signal was significantly stronger than an antibody signal, markedly improving the sensitivity of expansion microscopy and correlative light and electron microscopy. Importantly, proteins within phase-separated regions, such as the central channel of the nuclear pores, the nucleolus, or RNA granules, were readily detected with streptavidin, while most antibodies failed. When TurboID is used in tandem with an HA epitope tag, co-probing with streptavidin and anti-HA can map antibody-accessibility and we created such a map for the trypanosome nuclear pore. Lastly, we show that streptavidin imaging resolves dynamic, temporally, and spatially distinct sub-complexes and, in specific cases, reveals a history of dynamic protein interaction. In conclusion, streptavidin imaging has major advantages for the detection of lowly abundant or inaccessible proteins and in addition, provides information on protein interactions and biophysical environment.
Discarded sequencing reads uncover natural variation in pest resistance in Thlaspi arvense
Authors: Galanti Dario , Jung Jun Hee , Müller Caroline , Bossdorf Oliver
Published: April 2024

Understanding the genomic basis of natural variation in plant pest resistance is an important goal in plant science, but it usually requires large and labour-intensive phenotyping experiments. Here, we explored the possibility that non-target reads from plant DNA sequencing can serve as phenotyping proxies for addressing such questions. We used data from a whole-genome and -epigenome sequencing study of 207 natural lines of field pennycress (
Thlaspi arvense
) that were grown in a common environment and spontaneously colonized by aphids, mildew and other microbes. We found that the numbers of non-target reads assigned to the pest species differed between populations, had significant SNP-based heritability, and were associated with climate of origin and baseline glucosinolates content. Specifically, pennycress lines from cold and thermally fluctuating habitats, presumably less favorable to aphids, showed higher aphid DNA load, i.e. decreased aphid resistance. Genome-wide association analyses identified genetic variants at known defense genes but also novel genomic regions associated with variation in aphid and mildew DNA load. Moreover, we found several differentially methylated regions associated with pathogen loads, in particular differential methylation at transposons and hypomethylation in the promoter of a gene involved in stomatal closure, likely induced by pathogens. Our study provides first insights into the defense mechanisms of
Thlaspi arvense
, a rising crop and model species, and demonstrates that non-target whole genome sequencing reads, usually discarded, can be leveraged to estimate intensities of plant biotic interactions. With rapidly increasing numbers of large sequencing datasets worldwide, this approach should have broad application in fundamental and applied research.
Investigating the role of vitamin D in asthma
Authors: Sharma Siddhant , Garg Mayank
Published: April 2024

Results in mice suggest that vitamin D reduces the symptoms of asthma by controlling an immune response that leads to inflammation of the airways.
Real time search with linear temporal goals
Authors:   , Middleton Moreno Jaime Andrés
Published: April 2024

In Real-Time Heuristic Search (RTHS) we are given a search graph G, a heuristic, and an objective, which is to find a path from a start node to a given goal node in G. As such, one does not impose any trajectory constraints on the path, besides reaching the goal. In this work we consider a version of RTHS in which temporally extended goals can be defined on the form of the path. Such goals are specified in Linear Temporal Logic over Finite Traces (LTLf), an expressive language that has been considered in many other frameworks, such as Automated Planning, Synthesis, and Reinforcement Learning, but has not yet been studied in the context of RTHS. We propose a general automata-theoretic approach for RTHS, whereby LTLf goals are supported as the result of searching over the cross product of the search graph and the automaton for the LTLf goal; specifically, we describe LTL-LRTA*, a version of LSS LRTA*. Second, we propose an approach to produce heuristics for LTLf goals, based on existing goal-dependent heuristics. Finally, we propose a greedy strategy for RTHS with LTLf goals, which focuses search to make progress over the structure of the automaton; this yields LTL-LRTA*A. In our experimental evaluation over standard benchmarks we show LTL-LRTA*A may outperform LTL-LRTA* substantially for a variety of LTLf goals.