bluuebunny/crossref_metadata_2025 huggingface dataset:
THE PURPOSE OF SHAFT-TYPE FURNACES OF THE WEST ASIAN METALLURGICAL PROVINCE
Authors:   Orenburg Federal Research Center, Ural Branch of RAS, Tkachev Vitaly V. , Bogdanov Sergey V. ,   Orenburg Federal Research Center, Ural Branch of RAS
Published: December 2022

The article addresses the problem of the functional purpose of shaft-type furnaces with chimneys found at the Late Bronze Age sites of Northern Eurasia. This category of thermal engineering structures became widespread in the eastern wing of the West Asian (Eurasian) metallurgical province. Thermal sets with flue channels are physical evidence of the implementation of technological algorithms of the pastoral model of metal production based primarily on multistage processing of secondary copper sulfides. Shaft furnaces with flues of the Ural-Kazakhstan region are functionally similar to the more structurally simple fi re pits-furnaces present in the structure of mining and processing complexes of the steppe Cis-Ural region. They were intended for decrepitation, pyrotechnic enrichment, and refining of ore protolith during a long fi re setting using brushwood and wood fuel at relatively low temperatures in the range of 600–800 °C. The degree of complexity of thermal engineering structures was determined by the nature of the raw materials used. Ordinary fi re pits turned out to be acceptable for ore-bearing complexes in the copper shales and sandstones of the steppe Cis-Ural region. The ores of the ultrabasic deposits of the Ural-Mugodzhar region were difficult to be processed and required the use of mine furnaces with flues, which were also characteristic of the metal production centers of the Kazakhstan mining and metallurgical region. Further improvement of thermal engineering structures with flue channels was due to the need to overcome the raw material crisis caused by the exhaustion of available sulfide reserves in secondary enrichment zones within ultrabasic deposits, and copper shale ore occurrences at the end of the Bronze Age. It required the transition to the use of chalcopyrite and greatly contributed to the discovery of iron metallurgy.
“A TERRIBLE DREAM” ABOUT THE FUTURE AS A VARIANT OF THE DEVELOPMENT OF HISTORY
Authors:   Yanka Kupala State University of Grodno, Avtukhovich Tatiana Ye.
Published: December 2022

Understanding of alternative models of the historical process and different variants of the development of events has become a sign of modern humanities including fiction. The article examines the post-apocalyptic works by D. Glukhovsky* and V. Martinovich, in which undesirable variants of the development of history are presented on the basis of extrapolation of negative trends of modernity into the future. The question is raised that both writers are united by their attention to the traditional topic for fantastic literature — namely of testing ideas, but in projection on the relevant for the 20th–21st centuries problem of language in its influence on the biological/anthropological nature of man. The relevance of this problem is due to the fact that modern civilization is experiencing a conflict of languages symbolically described in the biblical story about the construction of the Tower of Babylon — a conflict of heterogeneous philosophical, ideological, religious views and values, which is aggravated by information pressure. The purpose of the article — to identify similarities and differences in the approaches of writers to understanding this problem — determines the hypothesis and methodology of the study: the combination of genre analysis, hermeneutical and sociological approaches is designed to show the influence of national literary and cultural traditions on the understanding of modern problems. Based on the analysis of genre specifics and plot organization of novels, the possibility of their double reading is determined — as works of mass literature and as a reflection of the writers’ speculation on current philosophical concepts and negative scenarios of the development of history. It is shown that D. Glukhovsky* considers the problem of language as an inability to communicate with the future (“Metro 2033”), as a loss of subjectivity under the influence of information flows (“Twilight”) and the release of aggression (“Post”). V. Martinovich considers language as a code defining national identity and a condition for the existence of a nation (“Mova 墨瓦”), raises the question that the Internet era has formed a new anthropological variety — “an inactive person” who is unable to find a way out of any situation without prompting search engines on the Internet (“Night”).
Percepção de uso e preparo químico mecânico realizado com diferentes instrumentos endodônticos por estudantes de graduação em Odontologia
Authors: Serafini Júlia Alievi , Portugal Bruna Neves , Scherer Maitê Munhoz , Lenzi Tathiane Larissa , Luisi Simone Bonato
Published: December 2022

O estudo revisou a literatura existente com o objetivo de comparar a percepção de uso, qualidade e tempo do preparo químico mecânico de canais radiculares realizado por estudantes de graduação em Odontologia com instrumentos de níquel-titânio (NiTi) e aço inoxidável. Para isso, as bases de dados eletrônicas PubMed, LILACS, Scopus, Embase, SciELO e CENTRAL foram acessadas para verificar e selecionar estudos relacionados com a questão de pesquisa publicados até janeiro de 2021. Estudos laboratoriais que compararam o uso de instrumentos de NiTi com aço inoxidável por alunos de graduação em Odontologia foram avaliados. Dois revisores independentemente selecionaram os estudos, coletaram os dados e analisaram o risco de viés. Dos 92 estudos potencialmente relevantes, 10 atenderam aos critérios de inclusão para análise de texto completo e, posteriormente, incluídos na revisão sistemática. O risco de viés foi considerado alto em todos os estudos. Instrumentos de NiTi apresentaram maior preferência e melhor percepção por estudantes de graduação em Odontologia, menor tempo e melhor qualidade do preparo químico mecânico, com menor ocorrência de acidentes como degraus, transporte e desvios de canal, apesar de estarem associados à maior ocorrência de fratura de instrumentos.
Determinants of Family Resilience in Female-Headed Families on the North Coast of Java
Authors: Ardi Mohammad Noviani , Tulab Tali , Yurista Dina Yustisi , Sariroh Aliyatus
Published: December 2022

This study analyzes the relationship between religiosity, education, and social support to family resilience in women-headed households. Family resilience is an exciting issue discussed today, seeing the fragility of the couple's understanding based on the family itself. It is essential because it protects from life problems and difficulties arising from the internal or external family, including groups, environments, communities, and countries. The results of this study contribute to efforts to increase family resilience, especially in women-headed homes, because family resilience is the main foundation in realizing community resilience as one of the efforts to boost national development. The power of national development is sourced to families as small groups in society. Thus, an in-depth study of the factors that affect family resilience to create a prosperous family, resistance, and continuity of national development is needed. The research method uses a quantitative approach and collects data using surveys of 15-20 women-headed households in Sayung, Demak. Data analysis is carried out with Validity Test, Reliability Test, and Regression Analysis using SPSS software. This study showed that education positively and significantly affects family resilience. In contrast, religiosity and social support have a positive and insignificant impact. The government can be used as a reference in decision-making to help economic resilience in women-headed households by making programs to increase family resilience in economics.
TECNOLOGIAS EDUCACIONAIS PARA O ENSINO DE ENFERMAGEM NO DISTANCIAMENTO SOCIAL: REVISÃO INTEGRATIVA
Authors: Sousa Maia Déborah Hevelly de , Marinho Joselane izaquiel , Nicácio Jaciely Gondim Sidrônio , Silva Freitas Jucicleia Maiara da , Pimentel Edlene Régis Silva , Ribeiro Luana Carla Santana , Andrade Lidiane Lima de
Published: December 2022

Objetivo: mapear as tecnologias educacionais utilizadas para apoiar o ensino de semiologia e semiotécnica em enfermagem durante o distanciamento social ocasionado pela pandemia de COVID-19. Métodos: realizou-se revisão integrativa da literatura por meio de busca nas bases de dados MEDLINE, CINAHL, Scopus e Library, information Science & Technology Abstract, com a questão norteadora: quais as tecnologias educacionais utilizadas para apoiar o ensino de semiologia e semiotécnica durante o distanciamento social? Resultados: a amostra foi composta por sete artigos, quanto ao tipo de tecnologia, vídeos educativos foram predominantes, acerca dos conteúdos abordados, encontrou-se cuidado de feridas, aplicação de injeção intramuscular ventroglútea, medida indireta da pressão arterial, banho no leito, estratégias efetivas de prevenção, manejo, tratamento e controle da hipertensão arterial, pensamento crítico por meio da aplicação do processo de enfermagem, habilidades de segurança do paciente. Considerações finais: as tecnologias educacionais utilizadas para apoiar o ensino de Semiologia e Semiotécnica durante o distanciamento social foram imprescindíveis para continuidade do processo de ensino-aprendizagem, evidenciando a continuidade do ensino para formação de futuros profissionais de enfermagem através da ampliação do acesso e das ferramentas tecnológicas para o processo de ensino-aprendizagem.
High Performance Sound Absorbing Glass Composites
Authors:   Belgorod State Technological University. V. G. Shukhova, Puchka O. V. , Bessmertnyi V. S. ,   Belgorod State Technological University. V. G. Shukhova, Platov Yu. T. ,   Plekhanov Russian University of Economics, Zdorenko N. M. ,   Belgorod University of Cooperation, Economics, and Law, Platova R. A. ,   Plekhanov Russian University of Economics
Published: December 2022

Разработана технология стеклокомпозитов звукопоглащающих с регулируемой поровой структурой на основе комплексного газообразователя, включающего природный колеманит и мел. Использование в составе пенообразующей смеси комплексного газообразователя позволило сформировать полимодальную пористость для поглощения звуковых волн в широком частотном диапазоне за счет уменьшения количества неактивных пор в структуре стеклокомпозита. Учитывая эксплуатационные свойства, звукопоглащающий стеклокомпозит рекомендован не только для улучшения акустических свойств при внутренней отделке помещений, но и в ограждающих конструкциях зданий и сооружений.
Composite glass-ceramic material based on cullet and colemanite
Authors:   Belgorod State Technological University. V. G. Shukhova, Bessmertnyi V. S. , Bondarenko M. A. ,   Belgorod State Technological University. V. G. Shukhova, Zdorenko N. M. ,   Belgorod University of Cooperation, Platov Yu. T. ,   Plekhanov Russian University of Economics, Platova R. A. ,   Plekhanov Russian University of Economics, Izotova I. A. ,   Belgorod State Technological University. V. G. Shukhova
Published: December 2022

Синтезирован стеклометаллический композиционный материал на основе глины, стеклобоя и колеманита. Разработана технология получения стеклокристаллического материала на основе изучения и уточнения особенностей механизма дегидратации колеманита. Исследован фазовый состав макро- и микроструктуры композита и его эксплуатационные показатели свойств.
Diseño, implantación y evaluación de un servicio de Sistemas Personalizados de Dosificación en una farmacia institucional de la ciudad de Córdoba
Authors: Martin Yanel , Cabral Gabriel , Salazar Zaffaroni Maria Fernanda , Armando Pedro
Published: December 2022

INTRODUCCIÓN

El Servicio Profesional Farmacéutico Asistencial (SPFA) de provisión de Sistemas Personalizados de Dosificación (SPD) consiste en reacondicionar y unificar, de manera protocolizada y en dispositivos multicompartimentales, los medicamentos que emplea un paciente, ordenándolos según su pauta posológica. El objetivo fue diseñar, implantar y evaluar un SPFA de SPD en una farmacia institucional de la ciudad de Córdoba.

MÉTODOS

Estudio observacional, descriptivo y longitudinal. Se desarrolló de un Procedimiento Normalizado de Trabajo (PNT) para el SPFA de SPD y se aplicó a una muestra de 20 pacientes. Se analizó la adherencia mediante: recuento de comprimidos y test de Morisky-Green. Se aplicó un cuestionario validado de satisfacción del servicio y se realizó un análisis de costos considerando la inversión inicial y los tiempos involucrados.

RESULTADOS

Se obtuvo un 98,0% de adherencia por recuento de comprimidos y por Test de Morisky-Green, 5,0% al inicio del servicio y 55,0% a los 3 meses.  Los pacientes expresaron en el cuestionario de satisfacción:  90,0% muy satisfecho y 10,0% satisfecho.  Respecto al análisis de costos, la inversión inicial fue de USD 1.670,44. Se calculó un valor de U$4,29 para la primera entrevista y el costo mensual de preparación, desde USD 16,02 para 7-30 tomas semanales hasta USD 28,73 para más de 121 tomas.

CONCLUSIÓN

Fue posible desarrollar e implantar un PNT para el SPFA de SPD, con mejoras significativas en la adherencia. Se observó un elevado grado de satisfacción del paciente y se obtuvieron los costos operativos mínimos para conseguir su sostenibilidad.
Alternativas terapéuticas de osteonecrosis maxilar asociada a medicamentos (ONMAM)
Authors: Leonardi Nicolás , Gilligan Gerardo , Piemonte Eduardo , Panico René
Published: December 2022

Introducción: La Osteonecrosis Maxilar asociada a Medicamentos (ONMAM) constituye uno de los efectos adversos más relevantes en el tratamiento con drogas antirresortivas como bifosfonatos y denosumab. Patologías oncológicas como mieloma múltiple, cáncer de mama, próstata, y alteraciones óseas-metabólicas como la osteoporosis lideran las indicaciones para estas terapias antirresortivas. El tratamiento es complejo debido a que muchas veces, la enfermedad es refractaria a la terapéutica aplicada. Se describen tratamientos farmacológicos, conservadores y quirúrgicos. Objetivo: El objetivo de este trabajo es reportar dos casos clínicos de ONMAM tratados con dos protocolos terapéuticos diferentes y el análisis de la literatura disponible en la actualidad sobre estos aspectos en base a la clasificación clínica definida por la American Association of Oral and Maxillofacial Surgeons (AAOMS). Conclusión: Los pacientes que desarrollan cuadros clínicos bucales de gran morbilidad como lo es ONMAM, pueden ver condicionada su calidad de vida y sufrir un agravamiento de su patología de base. El tratamiento de ONMAM está condicionado al estadio de la enfermedad, el éxito del mismo depende del manejo interdisciplinario y de un estricto seguimiento clínico médico y odontológico, así como también un riguroso monitoreo para evitar o detectar precozmente futuras recurrencias.
Risks of Using Cryptoassets in Russia and the Potential for Mitigation
Authors:   Financial Research Institute, Moscow 127006, Russian Federation, Sannikova Larisa V.
Published: December 2022

The development of the cryptocurrency market and its growing integration into the global financial system has heightened the debate about the risks of cryptoassets to both the global financial system and national financial systems. This paper analyzes the main risks associated with cryptoassets, highlighted both internationally and nationally. These include consumer risks; money laundering and terrorist financing risks; environmental risks; and financial stability risks. The main purpose of the study is to identify the risks of cryptocurrencies in relation to the Russian financial market. Although the risks are identical due to the extraterritorial nature of cryptoassets, the impact of these risks on countries' national financial systems differs significantly. Financial sanctions against Russia also force us to reconsider our established approaches to the assessment of existing cryptoasset risks. Russia has the technological and organizational capacity to mitigate most of the risks. An objective assessment of existing risks and development of balanced approaches to their management open up opportunities for creating a domestic crypto market and using cryptoassets to overcome the sanctions pressure on the Russian financial market.
Improving Internal Financial Control and Audit as Mechanisms to Increase the Efficiency of Budget Funds
Authors:   Federal Treasury Department for Moscow, Moscow 115191, Russian Federation, Lukashov Andrey I. ,   Plekhanov Russian University of Economics, Moscow 117997, Russian Federation
Published: December 2022

The article deals with the organization and implementation of internal financial control and internal financial audit in the public administration sector. This issue is of particular relevance due to regularly taken decisions to restrict (moratorium) the activities of internal state financial control bodies. At the same time, the current socio-economic situation in the country requires an increase in the amount of budget funds allocated to address important state objectives. Under such conditions, the importance of internal control mechanisms, allowing for targeted and effective use of budget funds, increases. At the same time, the results of analytical activities carried out by the Federal Treasury indicate a significant number of shortcomings and difficulties on the part of the chief administrators of budgetary funds in the organization and implementation of audit. In this regard, the author, using methods of analysis of results, analysis of statistical data and analysis of official documents, conducted a study of the current system of internal financial control and internal financial audit. The empirical base of the study was formed by the results of analytical activities of the Federal Treasury, the results of monitoring the quality of financial management carried out by the chief administrators of federal budget funds, as well as regulatory legal acts of the Russian Federation and departmental legal acts of federal executive bodies regulating internal financial control and audit. According to the results of the study, proposals were developed to improve the efficiency of the internal financial control system and internal financial audit in the public administration sector.
ECOWAS as a Provider of Peacekeeping Assistance in Africa
Authors: Iutiaeva Irina
Published: December 2022

This article examines the peacekeeping experience of the Economic Community of West African Countries (ECOWAS). It traces the entire evolution of the union in peacekeeping – from the first missions in Liberia and Sierra Leone to the operation in the Gambia. The advantages and disadvantages of the ECOWAS security mechanism, established in 1999, the principles of its peacekeeping activities and the experience of carrying out operations are analyzed. A comprehensive assessment of ECOWAS as a provider of peacekeeping assistance in Africa is given, taking into account the remaining problem areas and objective achievements of the organization in the conflict settlement.
The Tasks for Russian African Studies under New Conditions and Measures to Improve the Efficiency of Science Management
Authors:   Institute for African Studies RAS, Abramova Irina
Published: December 2022

The article is devoted to the exposition of the author’s vision immediate tasks of Russian African studies and the development of a set of measures to improve the efficiency and overall optimization of the management of scientific research, primarily in the field of socio-political sciences under the new conditions imposed by the Special Military Operation, aggressive pressure and destructive steps of the united West, the general growth of confrontation on the world stage and crisis of the existing structures of world economic relations. The general main direction, both for African studies and for most other areas of domestic scientific research, is to increase the efficiency of the investments therein (investments in a broad sense, and not only financial!). In practical terms, this means a departure from artificial “numeral” and bibliometric criteria of the effectiveness of scientific activity in favor of unambiguous obtaining of the practical ultimate results, needed by the state today.
Germany’s Political and Economic Interests in Africa: Opportunities and Challenges
Authors: Savina Zoya
Published: December 2022

Today, Africa occupies an important place in Germany’s foreign policy agenda. Africa is a resource-rich continent, and many African countries are rapidly developing economies. In this regard, Germany is actively seeking to increase economic relations with Africa. Special attention is paid to assisting African countries in solving the problems of poverty, in the development of production, as well as the fight against the coronavirus pandemic. The article is devoted to the economic direction of German-African policy at the present stage. The author attempts to give an overview of current trends in German-African relations.
Implementasi Algoritma Breadth First Search dan Depth First Search Pada Aplikasi Kimia Hidrokarbon Berbasis Augmented Reality
Authors: Nicolas Ferdy , Suryantara I Gusti Ngurah
Published: December 2022

Hidrokarbon adalah cabang ilmu kimia yang mempelajari senyawa organik yang tersusun atas karbon dan hidrogen. Dalam representasinya, molekul hidrokarbon dapat dipetakan sebagai sebuah graph, dengan atom-atom karbon yang berperan sebagai node dalam graph tersebut dan koneksi antar atom yang berperan sebagai jalur dalam graph. Konsep representasi ini menjadi fokus utama penelitian, dimana molekul hidrokarbon yang dipetakan ke dalam graph dapat berinteraksi dengan algoritma yang memiliki kemampuan untuk membaca graph, seperti Breadth First Search (BFS) dan Depth First Search (DFS). Kedua algoritma ini dapat digunakan pada graph berupa struktur molekul hidrokarbon untuk mendapatkan informasi mengenai molekul tersebut. Penelitian ini bertujuan untuk mengimplementasikan algoritma BFS dan DFS untuk melakukan identifikasi dan penamaan terhadap molekul hidrokarbon berdasarkan aturan IUPAC. Program yang dihasilkan kemudian dikemas ke dalam sebuah aplikasi berbasis augmented reality untuk memudahkan visualisasi molekul. Hasil penelitian menemukan bahwa algoritma BFS dan DFS dapat digunakan secara sinergis untuk mengidentifikasi struktur molekul dengan mengumpulkan informasi mengenai rantai terpanjang menggunakan BFS dan keberadaan rantai siklik dan rantai cabang menggunakan DFS. Dengan menggunakan metode unit testing, diketahui bahwa aplikasi memiliki konformitas senilai 100% terhadap standar nomenklatur dari IUPAC.
Sistem Pakar Prediksi Penyakit Diabetes Menggunakan Metode K-NN Berbasis Android
Authors: Susanto Cucut , Taufiq Taufiq , Hasmin Erfan , Aryasa Komang
Published: December 2022

Diabetes tipe 2 atau diabetes melitus adalah penyakit jangka panjang saat kadar gula darah pada tubuh bernilai tinggi melewati batas normal karena adanya resistensi insulin sehingga tubuh kesulitan mengubah glukosa menjadi energi. Salah satu penyakit yang paling umum diderita banyak orang adalah diabetes tipe 2 terutama pada orang dewasa dan lansia dikarenakan gaya hidup yang tidak sehat, seperti kurang olahraga dan pola makan yang salah. Kondisi ini jika dibiarkan tanpa penanganan dapat menyebabkan terjadinya komplikasi penyakit seperti serangan jantung, kehilangan penglihatan, stroke, dan gagal ginjal. Sebagian besar orang tidak mengetahui kalau dirinya mengidap penyakit ini dan hanya tahu ketika mereka mengalami beberapa gejala serius, untuk menghindari hal tersebut pendiagnosaan dini perlu dilakukan. Penelitian ini dilakukan untuk merancang aplikasi sistem pakar berbasis android untuk memprediksi kemungkinan seseorang mengalami penyakit diabetes dengan menerapkan metode K-Nearest Neighbor (KNN), agar masyarakat lebih cepat sadar dan menghindari resiko penyakit dengan mengubah pola hidup menjadi lebih sehat. Hasil pengujian sistem aplikasi dengan black box menunjukan bahwa fungsi-fungsi pada aplikasi dapat berjalan lancar dengan tingkat keberhasilan 100% dan hasil pengujian akurasi dari 50 data testing mendapatkan nilai sebesar 72%.
Sentiment Analysis of Online Lectures Tweets using Naïve Bayes Classifier
Authors: Waworundeng Jacquline Morlav S. , Sandag Green Arther , Sahulata Reynoldus Andrias , Rellely Godlife Davidson
Published: December 2022

Online lecture is an alternative learning method during the Covid-19 pandemic. There are opinions with pro and contra of the learning method. The purpose of this study is to evaluate the tweets of opinion or sentiment retrieved from social media Twitter regarding online lectures among the Indonesian community. Twint is used to collect the data tweet and Jupyter notebook is for text preprocessing and classification. The processes started with scraping data from Twitter, text preprocessing, and text classification. Using the Naïve Bayes classifier shows the performance has a precision value of 100%, an accuracy value of 70.8%, an F-measure of 10.2%, and a recall value of 5.4%. Performance rating can be affected by the dataset used for modeling. This analysis covers the positive sentiment and negative sentiments toward online lectures and the result shows 69% negative sentiments and 31% positive sentiments. The negative sentiments had a higher percentage compared to positive sentiments. The results were also supported by the word cloud which expressed a high frequency of negative words such as sleep problems, bored, tired, dizzy, difficult and lazy. So, it is concluded that during the Covid-19 pandemic from August 1, 2020, to May 31, 2021, Twitter users in Indonesia had negative sentiments about online lectures.
Aplikasi Jasa Titip Belanja Berbasis Mobile di Minahasa Utara
Authors: Adam Stenly Ibrahim , Mononutu Mark Jibril , Damping Glainhard
Published: December 2022

Berbelanja merupakan kegiatan yang dilakukan manusia untuk memenuhi kebutuhan pokok mereka sehari-hari. Ada banyak cara berbelanja saat ini, salah satunya adalah berbelanja secara online. Belanja secara online memudahkan orang untuk dapat berbelanja dari rumah tanpa harus pergi ke toko serta tidak perlu khawatir dapat menghabiskan waktu, sehingga berbelanja secara online merupakan pilihan terbaik karena lebih praktis dan efisien. Oleh karena itu, peneliti bertujuan  untuk merancang Aplikasi mobile Jasa Titip Belanja di Minahasa Utara. Perancangan aplikasi ini menggunakan metode Scrum dengan teknologi yang digunakan adalah bahasa pemrograman Javascript dengan kerangka kerja React Native dan ReactJS, serta Firebase sebagai database yang digunakan. Hasil akhir dari penelitian ini adalah aplikasi mobile untuk pengguna pelanggan dan kurir, juga aplikasi web untuk pengguna admin dan toko. Kedua aplikasi telah diuji dan dapat berjalan dengan baik. Manfaat dari penelitian ini yaitu mempermudah masyarakat untuk dapat memenuhi kebutuhan berbelanjanya serta dapat memberikan penghasilan tambahan bagi masyarakat yang ingin menjadi kurir dalam aplikasi ini.
Manajemen Risiko Divisi Sistem Informasi Pada Universitas Bina Insan Menggunakan Framework Cobit 5
Authors: Juminovario Juminovario , Negara Edi Surya
Published: December 2022

Universitas Bina Insan sudah banyak melakukan pengembangan terhadap kemajuan teknologi informasi khususnya sistem informasi, seperti contoh dengan adanya Sistem Akademik/ portal akademik. Puskom menterjemahkan visi dan misi UnivBi ke dalam sebuah inovasi teknologi informasi. Unit Puskom UnivBi, disadari terdapat beberapa hal yang belum maksimal hal ini karenakan sedikitnya jumlah pegawai yang mempunyai kemampuan dalam mengatasi risiko yang mungkin dapat terjadi secara tiba tibadan belum tersedianya dokumen standar prosedur untuk menangani risiko, serta belum dilakukan penilaian tingkat kapabilitas risiko sehingga pengendalian risiko berlum berjalan dengan baik. Untuk mendukung penelitian ini maka di rujuklah beberapa hasil penelitian sebelumnya sebagai landasan dalam kegiatan analisa manajemen risiko IT. Dari hasil penelitian ini didapatkan pihak Universitas Bina Insan telah mengimplementasikan proses Ensure Risk Optimation dan Manajemen Risiko, ini dibuktikan dengan hasil capaian kapabilitas yang berada pada level 3, yang mana artinya performed process, tetapi pihak Universitas Bina Insan belum optimal dalam pengoperasiannya. Nilai gap yang dihasilkan dari domain APO12 adalah 1 dan domain EDM03 adalah 2. Nilai gap ini menunjukan bahwa kondisi tata kelola sistem informasi pada Universitas Bina Insan masih belum baik serta belum sesuai dengan apa yang targetkan oleh pihak Universitas
PERAN IPS DALAM MEMBENTUK KARAKTER GENERASI MUDA
Authors: Andika Dion Boby
Published: December 2022

The younger generation is a picture of the future of a country, so that the younger generation must have good and strong character in social life, character must be built from an early age to perfect a better future life. Social studies learning plays an active role in shaping the character of the younger generation, where the role of social studies learning is to develop students' knowledge, understanding, and analytical skills of the social conditions of society. The main problem that often occurs is that the inculcation of character in students in schools has not been maximized because social studies learning is currently still theoretical. Even though the essence of this learning is to shape students to become good citizens which are applied in the life of society and the nation.
Differential expression of S100A10 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of S100A10, encoding S100 calcium-binding protein A10, in the skeletal muscle of patients with ALS. S100A10 was also differentially expressed in fibroblasts isolated from patients with ALS. S100A10 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control skeletal muscle. These analyses will begin to define the transcriptional landscape of ALS.
جمع البيانات
Authors: Kehrr Blahar O. A.
Published: December 2022

جمع البيانات هو عملية جمع وقياس المعلومات حول المتغيرات المستهدفة في نظام قائم،والذي يمكّن الفرد بعد ذلك من الإجابة على الأسئلة ذات الصلة وتقييم النتائج.
The Low Permeability of the Earth’s Precambrian Crust
Authors: Ferguson Grant , McIntosh Jennifer , Warr Oliver , Sherwood Lollar Barbara
Published: December 2022

The large volume of deep groundwater in the Precambrian crust has only recently been understood to be relatively hydrogeologically isolated from the rest of the hydrologic cycle. Currently, the paucity of permeability measurements in the Precambrian crust is a barrier to modeling fluid flow and solute transport in these low porosity and permeability deep environments. Estimates of permeability from prograde metamorphic rocks and geothermal systems have been applied to such groundwater systems, but, as data are few, it is unclear how appropriate this is for Precambrian crust on a global scale. To resolve this, we apply a new approach to constrain permeabilities for Precambrian crust to depths of 3.3 km based on fluid residence times estimated from noble gas analyses. The additional data reveals there is no statistically significant relationship at depths below 1 km, challenging the previous assumption of a global correlation between permeability and depth. Additionally, we show that estimated permeabilities at depths >1 km are at least an order of magnitude lower than previous estimates and possibly much lower. As a consequence, water and solute fluxes at these depths will be extremely limited, imposing important controls on elemental cycling and the distribution of subsurface microbial life.
Commentary: Responsible Research Assessment: Implementing DORA for hiring and promotion in psychology
Authors: Sandoval-Lentisco Alejandro
Published: December 2022

Commentary on Gärtner, A., Leising, D., & Schönbrodt, F. D. (2022, November 25). Responsible Research Assessment II: A specific proposal for hiring and promotion in psychology. https://doi.org/10.31234/osf.io/5yexm
Historical, Current, and Future Therapeutic Strategies to treat Parkinson’s Disease
Authors: Battu Varan
Published: December 2022

Parkinson's Disease (PD) is the second most common neurodegenerative disease and annually affects 3% of the population around the age of 60 years old. PD is a progressive neurological disorder that occurs from the loss of dopaminergic neurons in the substantia nigra pars compact. Symptoms such as tremors, involuntary movement, bradykinesia, or rigidity are common in patients with PD. Many people continue to suffer from this disorder, a prominent example being Muhammad Ali who retired from his boxing career in his late 30s. Over the years, treatments to remedy the symptoms of the disease have been manufactured, such as Levodopa, dopamine agonists, and various types of inhibitors. Although Levodopa has been the prime treatment for Parkinson’s for over 40 years, complications have risen in long-term levodopa therapy where patients displayed symptoms such as dyskinesia, dystonia, and speech impairment. In order to treat these side effects, scientists have developed dopamine agents to play an adjunctive role in the treatment process which temporarily prevent these symptoms from appearing. Moreover, scientists are still designing new methods to counter the symptoms of PD, such as enteral infusion of levodopa gel and ion channel fibers which are more effective than the treatments utilized today. All in all, in this paper I present an overview of the mechanisms and advantages/disadvantages of levodopa, dopamine agonists, and various inhibitors while also mentioning new techniques that will be exploited in the future.
Etiopathogenetic factors and neurobiological links between traumatic brain injury and Parkinson’s Disease: The Case of Muhammad Ali
Authors: Battu Varan
Published: December 2022

Parkinson’s Disease (PD) is a neurological disorder characterized by the loss of dopaminergic neurons of the substantia nigra pars compacta (SNc). Several predisposing and pathogenic factors have been implicated in PD, all of which lead to the activation of the intracellular machinery of programmed cell death, eventually killing the dopaminergic neurons. These etiopathogenetic factors include oxidative stress associated with mitochondrial dysfunction, proteolytic stress associated with ubiquitin-proteasome system dysfunction, local inflammation, environmental factors such as pesticides, and genetic mutations. Moreover, there has been a strong molecular association between the pathogenesis of traumatic brain injury (TBI) and the development of Parkinson’s Disease. In particular, TBI affects the molecular mechanisms that are fundamental to the formation of pathological proteins, such as amyloid-β plaques, tau proteins, and Lewy Bodies which are implicated in dementia and PD. An icon in the boxing industry who was diagnosed with Parkinson’s Disease was Muhammad Ali. The clinical and neuropathological reasons that led to Muhammad Ali’s diagnosis of the disease remain controversial. In this work, we conduct a detailed review of the literature and examine pieces of evidence of the roles of the various etiopathogenetic factors in the neuronal loss that lead to Parkinson’s, and then illustrate synopses from Muhammad Ali’s personal life that are medically relevant to his PD case which might explain his diagnosis with the disease. The review is aimed to highlight from a neuroscience lens the dynamic interactions between the environmental, genetic, and inflammatory factors that the boxer had been exposed to during his personal and career lives, which might have been involved in the progression of his neurodegenerative disease.
Proximal and Distal Honor Fit and Subjective Well-Being in the Mediterranean Region
Authors: Kirchner-Häusler Alexander , Schönbrodt Felix D. , Uskul Ayse , Vignoles Vivian , Rodriguez-Bailon Rosa , Castillo Vanessa A , Cross Susan E. , Gezici-Yalçın Meral , harb charles , Husnu Shenel , Ishii Keiko , Karamaouna Panagiota , Kafetsios Konstantinos , Kateri Evangelia , Matamoros-Lima Juan , Miniesy Rania , Na Jinkyung , Özkan Zafer , Pagliaro Stefano , Psaltis Charis , Rabie Dina , Teresi Manuel , Uchida Yukiko
Published: December 2022

Introduction. People’s psychological tendencies are attuned to their socio-cultural context and culture-specific ways of being, feeling, and thinking are believed to assist individuals in successfully navigating their environment. Supporting this idea, stronger “fit” with one’s cultural environment has often been linked to positive psychological outcomes. The current research expands the cultural, conceptual, and methodological space of cultural fit research by exploring the link between well-being and honor, a central driver of social behavior in the Mediterranean region. Method. Drawing on a multi-national sample from eight countries circum-Mediterranean (N = 2,257), we examined the relationship between cultural fit in honor and well-being at the distal level (fit with one’s perceived society) using response surface analysis (RSA) and at the proximal level (fit with one’s university gender group) using profile analysis. Results. We found positive links between fit and well-being in both distal (for some, but not all, honor facets) and proximal fit analyses (across all honor facets). Furthermore, most fit effects in the RSA were complemented with positive level effects of the predictors, with higher average honor levels predicting higher well-being. Conclusion. Our findings highlight the interplay between individual and environmental factors in honor as well as the important role honor plays in well-being in the Mediterranean region.
Probabilistic Reasoning with Transformer Networks: An Application to Predicate Judgment
Authors: Bhatia Sudeep
Published: December 2022

Transformer networks that are trained on participant-generated feature norms have been shown to replicate several behavioral patterns observed in prior research on human semantic cognition. In this paper, I compare the predictions of these networks with participant evaluations of sentences sampled from a vast domain of discourse, with thousands of naturalistic predicates. I find that existing transformer networks make human-like predictions when given atomic sentences. However, they fail to capture participant evaluations of compound sentences with conjunctions, disjunctions, negations, and conditionals. Instead, participant responses are best captured by a Probabilistic Reasoner, which aggregates transformer judgments according to the rules of probability theory. These results suggest that human semantic cognition may also rely on a combination of associative processes and deliberative processes when judging complex statements about the world. In doing so they show how probabilistic cognitive modeling and neural network modeling can be integrated to study naturalistic high-level cognition.
Eine "mehr-als-digitale Anthropologie". Ethnografien der Partizipation und öffentlichen Verwaltung
Authors: Klausner Martina
Published: December 2022

In diesem Artikel entwickle ich eine Forschungsagenda für eine „mehr-als-digitale Anthropologie“ und verbinde hierzu Ansätze aus der Tradition der Digitalen Anthropologie mit den theoretischen Grundlagen einer Relationalen Anthropologie. Dies ermöglicht, so mein Argument, anthropologische Forschungen zum „Digitalen“ gegenüber essentialisierenden Vorannahmen, was das Digitale und das Analoge als differente Sphären ausmacht, abzusichern. „Mehr-als“ signalisiert zugleich eine Verwandtschaft meiner spezifischen Theoretisierung des „Digitalen“ mit ähnlichen aktuellen Ansätzen – wie beispielsweise einer mehr-als-menschlichen Anthropologie –, die sich einer binären Beschreibung und Aufteilung der Welt in Menschliches und Nicht-Menschliches, Natur und Sozialität, Technik und Kultur, in virtuelle und physische Räume, grundlegend entziehen. In den Fokus kommen vielmehr die fortlaufenden Übergänge, Übersetzungen, aber auch Lücken und Störungen, auf die wir dann stoßen, wenn wir Praxis als zentrale analytische Einheit zum Ausgangspunkt unserer Forschung machen. Im zweiten Teil des Artikels werde ich diesen Ansatz anhand ethnografischer Untersuchungen von Bürgerbeteiligung und öffentlicher Verwaltung in der Stadt Frankfurt am Main verdeutlichen. Wie ich zeige, verlagert der Ansatz einer mehr-als-digitalen Anthropologie die Aufmerksamkeit auf die weitergefassten Kontexte sogenannter smarter städtischer Verwaltung und Online-Bürgerbeteiligung und insbesondere auf die Arbeit, die mit nur partiell verbundenen Infrastrukturen und den vielfältigen Netzwerken einer mehr-als-digitalen Politik des Bürgerengagements einhergehen. Ein Ausblick in zukünftige Forschungslinien einer mehr-als-digitalen Anthropologie schließt den Artikel ab.
Differential expression of steroidogenic genes in MCF-7 cell lines by methanolic extract of Mallotus phillippensis
Authors: Benny Bimitha , Sandeshkrishna A , Samraj Sujith , John Preethy , Radhakrishnan Uma
Published: December 2022

The role of oestrogen in the development of breast cancer is well documented. The aberrant expression of genes involved in oestrogen hormone synthesis can be one of the causes of breast cancer. Suppression of these genes is considered a therapeutic option for the treatment of breast cancer. In the present study, we evaluated the effect of a methanolic extract of Mallotus phillippensis leaves on the expression of CYP19 and StAR genes in MCF-7 breast cancer cell lines. The half maximal inhibitory concentration (IC50) of the extract was found to be 190 µg/mL. MCF-7 cells treated with half IC50, IC50 and double IC50 of the extract that is 95, 190 and 380 µg/mL, was used for evaluating the effect on the gene. Methanolic extract of M. phillippensis at double IC50 doses, upregulated the expression of StAR and CYP 19 genes, whereas at half IC50 and IC50 doses downregulated StAR and CYP 19 gene expression. The gas chromatography mass spectrometry analysis revealed the presence of phytosterols, fatty acid analogues and terpenoids in the extract which contributed to differential expression of StAR and CYP 19 genes. The confirmation of detected compounds was carried out by Fourier transform infrared spectroscopy analysis. From this study, it is inferred that higher doses of methanolic extract of Mallotus phillippensis can be used for treatment of the oestrogen deficient conditions leading to infertility while at lower doses significantly reduces StAR and CYP 19 gene expression can be recommended for the treatment of breast cancer.
Modulatory potential of Tamarindus indica on steroidogenesis by targeting in vitro expression of CYP 19 and StAR genes in MCF-7 cell lines
Authors: Sandeshkrishna A , Benny Bimitha , Samraj Sujith , John Preethy , Radhakrishnan Uma
Published: December 2022

The use of medicinal plants for treating different ailments dates back to thousands of years through Ayurveda. They increased the efficacy of current chemotherapy while lowering the risk and side effects in cancer patients. The current study was carried out to identify the effect of methanolic extract of Tamarindus indica seed coat on the expression of CYP 19 and StAR gene in MCF -7 cell lines. The phytochemical analysis of T. indica seed coat extract was done through Gas chromatography- mass spectrometry and Fourier transform infrared spectroscopy. The half maximal inhibitory concentration (IC50) of the extract was discovered in a previous study using MTT assay and was found to be 32 µg/mL. The cells after treatment with extract at concentrations of 8, 16 and 32µg/mL produced a differential expression of CYP 19. There was a fold increase at IC50 concentration of the extract mean while the gene expression was decreased at higher and lower doses of IC50. On the other hand, a dose dependent fold increase was observed in the expression of StAR gene after treatment with the extract. The presence of Phyto steroids, fatty acid analogues and terpenoids were identified by gas chromatography mass spectrometry analysis. Fourier transform infrared spectroscopy analysis results supports the finding from GC-MS analysis. Even though there was an increase in the expression of StAR gene, there was a biphasic response with CYP19, which indicated a downregulation in the synthesis of oestrogen.
Trewia nudiflora: A potential source of new drugs
Authors: Sultana Razia , Milon Mohammad Mostafa Mohsin , Kader Md Abdul , Parvin Shumaia , Parvez GM Masud
Published: December 2022

Medicinal plants have long history of being using as traditional medicines in almost every corner of the earth. Various chemical constituents of the plant are responsible for the activities. The plant Trewia nudiflora, belongs to the Euphorbiaceae family and is found abundantly in South Asia and Eastern Australia. Almost all parts of the plant such as root, stem bark, leaf, fruit and seed possess bioactive chemical constituents. The major chemical constituents are taraxerone, betasitosterol, nudiflorine, trewiasine, dehydrotrewiasine and maytanbutine. Although various parts of the plant have potential activity against cancer, tuberculosis, anti-inflammatory, antiulcer and antimicrobial activities, but many activities like diabetes, arthritis, analgesic, anticoagulant has not yet been studied. So, this plant could be a potential source for the future research.
Academic Writing and Politics
Authors: Bhandari Laxman Prasad , Pokharel Prem Raj
Published: December 2022

Writers challenge the governing traditions and values, beliefs, and interests, so they can take a stand against injustice. Academic writing plays a vital role in the discursive construction and maintenance of the hegemony of the dominant class. The paper purposed to explore the link between academic writing and politics. Thus, we explore how academic writing empowers authors to influence various aspects of their lives using library research method in this paper. Applying Gramsci’s social theory, we discuss the relationship between academic writing and politics under four themes: writing in the global context, politics of academic language, writing and ideology, and the power of writing. The findings suggest that academic writing is connected with power, politics, and ideologies to influence and control others through intellectual and moral unity along with the accord of economic and political power. This paper also concludes that academic writing enhances people to organize the multitude of social beliefs about good or bad, or acceptable or unacceptable for them to bring change in their lives.