bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis y políticas de clusters: teoría y realidad
Authors:   Universidad de Deusto, Navarro Arancegui Mikel
Published: February 2025

El artículo comienza mostrando el distinto significado que se atribuye al término clusters por las distintas corrientes y autores tiene que ver con las diferentes opciones que en ellos se encuentran en torno a su marco espacial, a las organizaciones e instituciones que los constituyen, y a los tipos de relaciones entre empresas (de interdependencia o similitud) y de flujos (de productos o conocimientos) que se consideran. A continuación se muestran los factores manejados por la literatura para justificar la existencia de los clusters, así como los tipos de análisis y técnicas de investigación que se acostumbran manejar. En tercer lugar, se presentan y comentan las características que presentan los clusters en el mundo: implantación y desarrollo, edad, tamaño, tipos de empresas y de sectores, límites geográficos, tipos de relaciones entre sus miembros, competitividad y sus factores determinantes. Y, finalmente, se exponen cuáles son los fundamentos en que puede descansar la política de clusters, los principios a que ésta se debería ajustar y los diferentes tipos de políticas de clusters que cabría distinguir, en función del ámbito espacial de gobierno de la política y del ámbito espacial de la ventaja competitiva que se persigue.
Ciudades-región en Europa: innovación, aprendizaje y nueva gobernanza territorial
Authors:   Universidad de Cardiff, Morgan Kevin
Published: February 2025

Este artículo analiza los cambios en la gobernanza territorial en la Unión Europea como parte de la reorganización escalar del estado-nación subrayando las tensiones y dilemas que se derivan de la simultaneidad de los procesos de descentralización sub-nacional, por una parte, y la creación de estructuras supra-nacionales de gobernanza, por otra. En primer lugar, se considera la «escala regional » y su importancia en el «gobierno multi-escalar» en la Unión Europea. En segundo lugar, se examina el potencial y los límites de las acción regional en el campo de la innovación en el contexto de las regiones menos favorecidas en Europa, destacando su importancia en la regeneración regional. Y, en tercer lugar, se analiza la estrategia de desarrollo sostenible iniciada por el gobierno Galés, en el Reino Unido, para poner en evidencia tanto la necesidad de crear una nueva métrica para el desarrollo regional menos economicista y más sostenible, como de articular una gobernanza multiescalar interdependiente y compartida entre las escalas regional, nacional y supra-nacional.
Marketing de relaciones y creación de capital social. El caso de las agencias de desarrollo local
Authors:   Universidad de Burgos, Hernández Carrión Carlos , Camarero Izquierdo Carmen ,   Universidad de Valladolid
Published: February 2025

El problema del desarrollo local es abordado por disciplinas diferentes como son, entre otras, la sociología, la política económica, la geografía o la economía de la empresa. El marketing hace su particular aportación a través del incipiente «marketing territorial». A pesar de las diferencias entre disciplinas parece surgir un nexo común en torno a conceptos como «capital social» y «activos relacionales ». El presente artículo pretende acercarse al problema a través del marketing territorial y, más concretamente, a través de las actuaciones en materia de desarrollo llevadas a cabo por las agencias de desarrollo local. Estas actuaciones, desde un enfoque de marketing de relaciones, suponen que las agencias entren en contacto con distintos públicos-objetivo con los que establecerán relaciones más o menos estrechas. El objetivo del presente trabajo es aplicar el modelo del marketing de relaciones al contexto del desarrollo local y analizar la orientación relacional de cada grupo de agentes implicados en el desarrollo económico como medida para estimar la creación de capital social por parte de las agencias de desarrollo, así como la relación de dicha orientación con los resultados y los objetivos perseguidos. El estudio empírico se centra en el caso particular de las agencias de desarrollo de Castilla y León promovidas a nivel local y regional.
‘ಅಮರ್ ಕೊಂಕಣಿ’ ಷಣ್ಮಾಸಿಕ್ ಸರ್ವ್ ಕೊಂಕ್ಣಿ ಬೊಲಿ ಆನಿ ಸಂಸ್ಕೃತೆಂಚೆಂ ಪತ್ರ್.
Authors: Pinto Melwyn
Published: February 2025

ಹೊ ಅಂಕೊ ಮಾತ್ಸೊ ತಡವ್ ಕರ್ನ್ ತುಮ್ಚೆ ಹಾತಿಂ ಪಾವ್ತಾ. ತುಮಿ ಸಮ್ಜಾತೆಲ್ಯಾತ್ ಮ್ಹಣ್ ಪಾತ್ಯೆತಾಂ. ಕೊರೋನಾ ಆಜೂನ್ ಸಂಪೊಂಕ್ ನಾ. ತಶೆಂ ಸರ್ವ್ ಕಾಮಾಂಚೆರ್ ತಾಚೊ ಪರಿಣಾಮ್ ಪಡ್ಲಾ ಮ್ಹಳ್ಳೆಂ ಎದೊಳ್ಚ್ರ ಜಾಹೀರ್ ಜಾಲ್ಲೊ ವಿಷಯ್. ಸಂಪಾದನ್ ಆನಿ ಪ್ರಕಾಶನಾಚೆರ್ಯೀಾ ತಾಚೊ ಪ್ರಭಾವ್ ತಿತ್ಲೊಚ್ ಪಡ್ಲಾ ಮ್ಹಳ್ಳೆಂ ಪಳೆವ್ಯೆತ್. ಕೊಂಕ್ಣೆಚ್ಯಾ ಸಂದರ್ಭಿಂ ಕೊರೊನಾ ಉಪ್ರಾಂತ್ ನೆಮಾಳಿಂ ಉಸ್ವಾಸ್ ಕಾಡುಂಕ್ ಕಷ್ಟೊನ್ ಆಸಾತ್.
ತಶೆಂ ಮ್ಹಣ್ ‘ಅಮರ್ ಕೊಂಕಣಿ’ಚೊ ಸಮಸ್ಸೊ ತಸಲೊ ನ್ಹಂಯ್. ಹಾಂಗಾಸರ್ ಉತ್ತೀಮ್ ಸಂಶೋಧಾನಾತ್ಮಕ್ ಬರ್ಪಾಂ ತಯಾರ್ ಕರ್ಚಿಂ, ಯಾ ಹಾಡಂವ್ಚೆಂ ಏಕ್ ವ್ಹಡ್ ಸವಾಲ್ ಆಮ್ಕಾಂ ಆಸಾ. ಪರಿಗತ್ ಖಂಡಿತ್ ಬರ್ಯಾ ದಿಶೆನ್ ಚಲೊನ್ ಆಸಾ ಮ್ಹಳ್ಳೊ ವಿಚಾರ್ ದಾದೊಸ್ಕಾಯೆಚೊ.
ಹ್ಯಾ ಅಂಕ್ಯಾಂತ್ ಮೌಲ್ಯ್ಭಳರಿತ್ ಚಾರ್ ಸಂಶೋಧಾನಾತ್ಮಕ್ ಲೇಕನಾಂ ಆಮಿ ಫಾಯ್ಸ್ ಕರ್ತಾಂವ್. ‘ಅಮರ್ ಕೊಂಕಣಿ’ ಷಣ್ಮಾಸಿಕ್ ಸರ್ವ್ ಕೊಂಕ್ಣಿ ಬೊಲಿ ಆನಿ ಸಂಸ್ಕೃತೆಂಚೆಂ ಪತ್ರ್. ತ್ಯಾ ದಿಶೆನ್ ಸಾರಸ್ವತ್ ಬ್ರಾಹ್ಯಣಾಂಚ್ಯಾ ಲೋಕ್ವೇಂದಾ ವಿಶಿಂ ಏಕ್ ಲೇಕನ್ ಹ್ಯಾ ಅಂಕ್ಯಾಂತ್ ಆಸಾ. ಸಾರಸ್ವತ್ ಬ್ರಾಹ್ಮಣಾಂಚ್ಯಾ ಸಂಸ್ಕೃತೆಂತ್ ಗಿರೇಸ್ತ್ ಲೋಕ್ವೇಂದ್ ಆಸಾ ತೆಂ ಹ್ಯಾ ಲೇಕನಾ ದ್ವಾರಿಂ ಆಮಿ ಸಮ್ಜವ್ಯೆತ್.
ಕೊಂಕ್ಣಿ ಭಾಶೆ ವಿಶಿಂ ಆನಿ ಆಮಿ ಕಶಿ ತಿ ಚಡಿತ್ ವಾಪಾರಾಕ್ ಯೋಗ್ಯ್ ಕರ್ಯೆತ್ ಹ್ಯಾ ವಿಶಿಂ ಚಡ್ ಆನಿ ಚಡ್ ಆಟವ್ ಗರ್ಜೆಚೊ. ಹ್ಯಾ ಸಂದರ್ಭಿಂ `ಕೊಂಕ್ಣಿ ಕಾಲ್, ಆಜ್ ಆನಿ ಫಾಲ್ಯಾಂ: ಏಕ್ ಚಿಂತಪ್' ಲೇಕನ್ ಕಾಂಯ್ ಥೊಡೊ ದಿಶ್ಟಾವೊ ದೀಂವ್ಕ್ ಸಕಾತ್.
ಮೊಂತಿ ಫೆಸ್ತ್ ಆಮ್ಕಾಂ ಪಡ್ಲಾ ಕರಾವಳೆಚ್ಯಾ ಕ್ರಿಸ್ತಾವಾಂಕ್ ಏಕ್ ಪ್ರಮುಕ್ ಫೆಸ್ತ್. ಹ್ಯಾ ಫೆಸ್ತಾಕ್ ತಾಚಿಚ್ ಮ್ಹಳ್ಳಿ ಚರಿತ್ರಾ ಆಸಾ ತರೀ ತ್ಯಾ ಚರಿತ್ರೆ ವಿಶಿಂ, ವಿಶೇಸ್ ಕರ್ನ್ ಮೊಂತಿ ಫೆಸ್ತಾಚ್ಯಾ ಸುರ್ವಾತೆ ವಿಶಿಂ, ಸ್ಪಷ್ಟತಾ ದಿಸಾನಾ. ಹ್ಯಾ ಅಂಕ್ಯಾಂತ್ ಫಾಯ್ಸ್ ಜಾಲ್ಲೆಂ ಲೇಕನ್ `ಮೊಂತಿ ಫೆಸ್ತಾಚ್ಯಾ ಭೊಂವಾರಿಂ..' ಹ್ಯಾ ಫೆಸ್ತಾಚ್ಯಾ ಚರಿತ್ರೆ ವಿಶಿಂ ಚಡಿತ್ ಉಜ್ವಾಡ್ ಫಾಂಕಂವ್ಕ್ ಸಕ್ತೆಲೆಂ ಮಾತ್ರ್ ನ್ಹಂಯ್ ಜಾಣ್ಕಾರ್ಯಾಂಕ್ ಆನಿಕೀ ಚಡಿತ್ ಚರ್ಚಾ ಕರುಂಕ್ ಪ್ರೇರಣ್ ದಿತೆಲೆಂ ಮ್ಹಳ್ಳೊ ಆಮ್ಚೊ ಭರ್ವಸೊ.
`ಸಾಯ್ಬಾ ಭೊಗೊಸ್' ಆನಿ `ವ್ಹಡ್ಲೆಂ ಘರ್' ಹ್ಯಾ ದೋನ್ ಕಾದಂಬರಿಂಚೊ ತುಲನಾತ್ಮಕ್ ಅಧ್ಯಯನ್ಯೀಲ ಹ್ಯಾ ಅಂಕ್ಯಾಂತ್ ಫಾಯ್ಸ್ ಜಾಲಾ. ಏಕ್ ಮಂಗ್ಳುರಿ ಕಥೊಲಿಕ್ ಬೊಲಿಂತ್ ಆನಿ ದುಸ್ರಿ ಗೊಂಯ್ಚ್ಯಾ ಬೊಲಿಂತ್ ಫಾಯ್ಸ್ ಜಾಲ್ಲಿ ಕಾದಂಬರಿ. ತರಿಕೀ ದೊನೀ ಚಾರಿತ್ರಿಕ್ ವಿಷಯಾಕ್ ಲಗ್ತಿ ಕಾದಂಬರಿ. ಅಸಲೆಂ ಅಧ್ಯಯನ್ ಏಕ್ ಬರಿ ವಾಡಾವಳ್ ಮ್ಹಣ್ ಆಮಿ ಲೆಕ್ತಾಂವ್. ಎಕಾ ಬೊಲಿಂತ್ಲೆಂ ವಾಚಪ್ ಥೊಡೆ ಪಾವ್ಟಿಂ ಹೆರ್ ಬೊಲಿಂತ್ಲ್ಯಾ ಲೊಕಾಕ್ ವಿವಿಧ್ ಕಾರಣಾಂ ನಿಮ್ತಿಂ ಪಾವಾನಾ ಮ್ಹಳ್ಳೆಂ ಆಮ್ಕಾಂ ಕಳಿತ್ ಆಸ್ಚೊಚ್ ವಿಷಯ್. ಪುಣ್ ತಸಲೆಂ ಪ್ರೇತನ್ ಆಮಿ ಕೆಲ್ಯಾರ್ ಮಾತ್ರ್ ಬೊಲಿ ಬೊಲಿ ಮದೆಂ ಚಡಿತ್ ಸಂಬಂಧ್ ಹಾಡುಂಕ್ ಸಾದ್ಯ್. ಮುಕಾರಿಂಯೀ ಅಸಲಿಂ ಲೇಕನಾ ಪ್ರಕಟ್ ಕರ್ಚೆಂ ಪ್ರೇತನ್ `ಅಮರ್ ಕೊಂಕಣಿ' ಕರ್ತೆಲೆಂ.
ಕೊರೊನಾಚಿ ಇಜಾ ಮಾತ್ಸಿ ಉಣಿ ಜಾಲ್ಯಾ ತರೀ, ಸಂಪೂರ್ಣ್ ಸಂಪ್ತೆಲಿ ಕೆದ್ನಾಂ ಮ್ಹಳ್ಳೆ ವಿಶಿಂ ಆಜೂನ್ ನಕ್ಕಿ ಸಾಂಗುಂಕ್ ಸಾದ್ಯ್ ನಾ. ತರಿಪುಣ್, ಸಾಹಿತ್ಯ್ ಆನಿ ಸಂಸೊದ್ ರಚ್ಣೆಕ್ ಕೊರೊನಾನ್ ತಿತ್ಲೊ ವ್ಹಡ್ಲೊ ಧಖೊ ದೀಂವ್ಕ್ ನಾ. ಚಡಿತ್ ಮೌಲ್ಯಾಧಾರಿತ್ ಬರ್ಪಾಂ ಮುಕಾರಿಂಯೀ ಯೇಂವ್ದಿತ್.
ಗೌಡಸಾರಸ್ವತ ಬ್ರಾಹ್ಮಣಾಂಚೆ ಲೊಕವೆದ್
Authors: Mallya Chandrika
Published: February 2025

ಜಿಎಸ್ಬಿಖ ವಾ ಗೌಡಸಾರಸ್ವತ ಬ್ರಾಹ್ಮಣ್ ಸಮುದಾಯಾಚೊ ಉಲ್ಲೇಕ್ ಋಗ್ವೇದಾಂತ್ ಆಸೊನ್, ಶತಮಾನಾಂ ಆದಿಂ ಆಳ್ವೊನ್ ಗೆಲ್ಲ್ಯಾ ಸರಸ್ವತಿ ನ್ಹಂಯ್ ತಡಿ (ಆತಾಂಚೊ ಪಂಜಾಬ್, ರಾಜಸ್ಥಾನ, ಪಾಕಿಸ್ತಾನ ಪ್ರದೇಶ್) ಥಾವ್ನ್ ವಿವಿದ್ ಕಾರಣಾಂಕ್ ಲಾಗೊನ್ ಭಾರತಾಚ್ಯಾ ದಕ್ಷಿಣಾಕ್ ಯೇವ್ನ್ ವಸ್ತೆಕ್ ಲಾಗ್ಲೊ. ಕರ್ನಾಟಕಾಕ್ ಆಯ್ಲೆಲ್ಯಾಂ ಪಯ್ಕಿ ಥೊಡೊ ಲೋಕ್ ಶಿವಮೊಗ್ಗ, ಉತ್ತರ್ ಕನ್ನಡ ಆನಿ ಹೆರ್ ಥೊಡೊ ದಕ್ಷಿಣ್ ಕನ್ನಡಾಂತ್ ಥಿರ್ ಜಾಲೊ. ಉಪ್ರಾಂತ್ಲ್ಯಾ ವರ್ಸಾಂನಿ ಗೊಂಯಾಂಥಾವ್ನ್ ದೆಶಾಂತರ್ ಆಯಿಲ್ಲೊ ಜಿಎಸ್ಬಿಆ ಸಮುದಾಯಾಚೊ ಲೋಕ್ಯಿಡ ಹಾಂಚೆ ಸಂಗಿಂ ಮೆಳೊನ್, ಪ್ರಸ್ತುತ್, ರಾಜ್ಯ್ ತಶೆಂ ದೆಶಾಚ್ಯಾ ದುಡ್ವಾ ಆನಿ ಹೆರ್ ವೆವ್ಹಾರಾಂತ್ ಭೊವ್ಚ್ೊ ನಾಂವಾಡ್ದೀಕ್ ಆಸಾ. ಹ್ಯಾ ಲೊಕಾಚ್ಯಾ ಗಿರೇಸ್ತ್ ಲೋಕ್ವೇ ದಾಚಿ ಮಟ್ವಿ ಪರಿಚಯ್ ಹ್ಯಾ ಲೇಖನಾಂತ್ ದಿಲ್ಯಾ.
Screening and Etiology of Congenital Heart Disease in Developing Countries : A Comprehensive Systematic Review
Authors: Dzakiyyah Fiddin  , Dhanista Hastinata Sukarna Putra  , Irkhamyudhi Primasakti
Published: February 2025

Introduction: The increasing number of newborns with congenital heart disease (CHD) shows that the global burden of CHD is still significant. This indicates that screening and prevention have not been carried out optimally. This study aims to determine the differences of screening and etiology of congenital heart disease (CHD) between developed and developing countries. Methods: A systematic review adhering to PRISMA 2020 guidelines was conducted. Studies from 2015 to 2025 focusing on the screening and etiology of CHD in developing and developed countries were included. Results: Twenty-three relevant studies were included. Combination of pulse oximetry (PO) and auscultation, or PO alone were the most common postnatal screening tools in developed and developing countries. For prenatal screening, ultrasound was commonly used. Artificial intelligence and genetic testing were only used in developed countries. The etiology such as genetics, maternal lifestyle or conditions were discussed. Conclusion: The urgent need for affordable early detection of congenital heart disease (CHD) in developing countries cannot be overstated, as it holds the potential to significantly reduce the global burden of this condition. By implementing comprehensive prenatal and postnatal screening programs, we can identify at-risk infants early, enabling timely interventions and improved health outcomes. Addressing this critical issue not only enhances individual lives but also strengthens healthcare systems and fosters healthier communities.
MACROECONOMIC VARIABLES AND THE PERFORMANCE OF NIGERIAN CAPITAL MARKET
Authors: YERIMA ISHAYA JABIL  , JOSEPH M. IBBIH  , FRANCIS A. AKAWU
Published: February 2025

This study examined the impact of macroeconomic variables on capital market performances in Nigeria covering the period 1990 to 2023. The study adopted the ex-post factor research design using Stock Exchange (NSE) and National Bureau of Statistics (NBS). The Non Liner Auto Regressive Distributed Log (NARDL) model was used for data analysis and Augmented Dickey-Fuller test was conducted to determine the stationarity of the time series variables. The NARDL result obtained shows that growth rate of GDP and exchange rate has a positive and significant impact on capital market performances in Nigeria, both in the short-run and in the long-run. On the other hand, interest rate has a negative and significant impact on capital market performance in the short-run and in the long run, but inflation rate has a positive but significant impact on capital market performances in Nigeria, in the short-run but in the long run inflation rate has insignificant impact on capital market performance in Nigeria. Based on these findings, the study therefore recommends among others that foreign exchange market should be regulated and properly monitored by the Federal Government/Central Bank of Nigeria through her exchange rate policies with a view to strengthen the local currency and reduce the impact of exchange rate fluctuation on capital market prices to enable the capital market to performed better.
Climate Change and India’s role in international agreements, its outcomes and failures
Authors: - Prof. Sandeep Kumar , - Dr. Saumya Modi
Published: February 2025

Climate change is a global phenomenon with a far- reaching consequences, and India, as one of the most populous and diverse countries, is significantly affected. The changing climate patterns, characterized by rising temperatures, erratic rainfall, and extreme weather events, pose sustainable challenges to India’s socio economic fabric.
ABP en el desarrollo de habilidades críticas en estudiantes de 8vo grado de educación básica de la UE Cumandá
Authors: Zabala Valdez Narcisa de Jesus
Published: February 2025

El presente estudio se direcciona a analizar la influencia del aprendizaje basado en proyectos en el desarrollo de habilidades críticas en los estudiantes de octavo grado de educación básica de la Unidad Educativa Cumandá. El estudio plantea una metodología de enfoque cuantitativo, diseño no experimental y alcance descriptivo. Se consideró una población de 88 estudiantes, de la cual se tomó una muestra de 72 participantes. Los datos se recopilaron a través de una encuesta. Se realizó un análisis descriptivo a través de cuadros de frecuencia. Los resultados evidenciaron que más allá de una limitada implementación de esta metodología, esta no se ajusta a las necesidades de los estudiantes, lo cual no solo influye de forma negativa en su aprendizaje, sino también en la oportunidad de fomentar el desarrollo de sus habilidades críticas.
АССИМИЛЯТИВНЫЕ ПРОЦЕССЫ В ОБЛАСТИ СОГЛАСНЫХ АНГЛИЙСКОГО ЯЗЫКА
Authors: Хожаназарова Ирода Шавкатовна
Published: February 2025

Статья посвящена на рассмотрению ассимилятивных процессов в области согласных английского языка. В английском языке ассимиляция согласных встречается в различных видах, таких как прогрессивная, регрессивная и ложная, и охватывает такие аспекты, как место, способ образования и звонкость звука. Анализируется основные виды ассимиляции согласных в английском языке, их характеристики, влияние на звуковой строй языка в целом и в частности. В процессе  научного исследования были использованы методы сравнения, лингвистического описания  что повлияло определить теоретическую и практическую значимость научной проблемы.
OʻZBEKISTONDA “YASHIL IQTISODIYOT”GA OʻTISH STRATEGIYASI VA UNING RIVOJLANISH TENDENSIYALARI
Authors: ABDUMANNOPOV Ismoiljon
Published: February 2025

Oʻzbekistonda “yashil iqtisodiyot”ga oʻtish, atrof-muhitni muhofaza qilish, tabiiy resurslarni samarali foydalanish va iqtisodiy rivojlanishni barqarorligini taʼminlashga qaratilgan kompleks strategiyadir. Bu strategiyaning asosiy yoʻnalishlari qayta tiklanuvchi energiya manbalarini rivojlantirish, energiya samaradorligini oshirish, ekologik toza texnologiyalarni tatbiq etish, barqaror qishloq xoʻjaligini rivojlantirish va tabiiy resurslardan oqilona foydalanishdan iborat.
Ushbu strategiyaning rivojlanish tendensiyalari, global iqtisodiy va ekologik oʻzgarishlarga javoban va mamlakatning ixtiyoriy ekologik siyosatlari bilan bogʻliq. Bular qayti tiklanuvchi energiyaga investitsiyalar, yuqori texnologiyalarni joriy qilish, va ekologik moliyalashtirish kabi sohalardagi ijobiy oʻzgarishlarni oʻz ichiga oladi.
SHOYIM BO‘TAYEVNING O‘ZBEK ADABIYOTIDA TUTGAN O‘RNI: ASARLARIDAGI O‘ZIGA XOSLIK
Authors: Yakubova Barnoxon
Published: February 2025

Biz ushbu maqolada Shoyim Bo‘tayevning adabiyot olamiga kirib kelishi, adibning hayoti va ijodi kimlar tomonidan o‘rganilgani va o‘rganilayotgani, asarlaridagi o‘ziga xos jihatlarni tahlil qildik  va mazmun-mohiyatini misollar orqali ochib berishga harakat qildik.
ADVANTAGES OF SYNTHETIC FLUID OR OILS OVER TRADITIONAL FUELS
Authors: Yulduz Khidirova Yulduz Tukhtaeva
Published: February 2025

This article highlights the relevance of synthetic liquid fuel production today. With the increase in the types and movement of land, air, and water transport in the world, fuel consumption is also increasing day by day. To meet the demand for fuel, a number of energy-efficient, environmentally friendly synthetic liquid fuel productions is being launched. In this regard, obtaining synthetic fuel using local raw materials is the most urgent task for chemists, technologists, and engineers who are currently studying synthetic fuel issues. In Uzbekistan GTL technology based on being taken synthetic from our fuels one diesel fuel​​ traditional​​ diesel to fuel​ relatively one how much advantage in return world to the standards answer is giving. This and the domestic market Our Republic's fuel demand is met oil and gas in the field the most big achievement​​ is  GTL diesel working release beginning Uzbekistan​​ fuel​​ independence strengthens and internal the market high good quality products with provides.​​
Ecosomatic Paradigm through Disability Studies in John Muir's My First Summer in the Sierra
Authors: Greenspan Gage
Published: February 2025

This essay argues that John Muir’s My First Summer in the Sierra provides a literary basis for Matthew J. C. Cella’s “ecosomatic paradigm,” while simultaneously complicating this paradigm, especially for its exclusion of mental disabilities. A critique of the ecosomatic paradigm is undertaken in order to expose its potential applicability to a wider range of disabled persons. The clearest instances of this critique appear in Muir’s passages depicting a “mad” shepherd, as well as a tree that has been damaged by a storm, which Muir likens to a man with a broken back. An analysis of instances in Muir’s text ultimately is shown to be in sync with Cella’s broader goal of opening up the scope of ecocriticism to incorporate elements of disability studies. This allows y First Summer in the Sierra to not only be read as a strong force in ecocriticism, but also as an early conception of disability discourse.
India Moving: A History of Migration by Chinmay Tumbe
Authors: Mantri Swati
Published: February 2025

In the face of recent global migration and humanitarian crisis unfolding in Indian sub-continent, South America, sub-Saharan region, and beyond, Chinmay Tumbe’s India Moving: A History of Migration is a timely reminder of treating migration as a dynamic phenomenon and not as a oneoff event wherein the transformative effect of journey on the migrant is ever-lasting.
ЕЩЕ РАЗ К ТРАКТОВКЕ «СЦЕНЫ ОПЛАКИВАНИЯ» НА ОССУАРИИ ИЗ ТОК-КАЛЫ
Authors: Тухтаева Малика
Published: February 2025

В данной статье в результате повторного обращения к расписному оссуарию из Ток-калы со «сценойоплакивания умершего», датированному ранним средневековьем, дается следующая новая трактовкаего сюжета. Анализ причёсок и костюмов персонажей на оссуарии из Ток-калы позволяет предполо-жить, что изображенные фигуры принадлежали тюркскому этническому пласту раннего средневековья.Изучение историографического материала показало, что оссуарий из Ток-калы был описан советски-ми искусствоведами фрагментарно. Здесь выявлены некоторые необоснованные выводы относитель-но гендерной принадлежности персонажей, где фигуры с длинными прическами и косами интерпре-тированы как женщины. Известно, что мужчины-тюрки времен Тюркского каганата носили одну илинесколько длинных кос. Это обстоятельство, радикально опровергающее предыдущие интерпретации,позволяет по-новому трактовать гендерную принадлежность изображенных фигур. Сравнение сюжетаи зороастрийского погребального обряда позволило предположить, что три фигуры, сидящие на землевозле покойника, поджав под себя ноги, представляют собой насассаларов – представителей специ-фического сословия зороастрийской общины, которые обычно управляли ритуалом подготовки телаусопшего к погребению. Обычным людям и близким было запрещено прикасаться к покойнику, онимогли смотреть на покойника только издали, что, видимо, отражено в этой части сцены.
ЭСКИ ХОВОСДАН ТОПИЛГАН МУРАККАБ ТАРКИБЛИ КАМОН ХУСУСИДА
Authors: Грицина Алексей , Раҳимов Комил , Мамиров Омон
Published: February 2025

Мақолада Эски Ховос ёдгорлигидан топилган мураккаб таркибли камон ва унинг қисмлари бўлган суякдан ясалган предметлар хусусида сўз боради. Мураккаб таркибли камон ва унинг қисмлари илмий ўрганилиб, уларнинг ясалиш усуллари ва турлари таҳлил қилинган. Эски Ховос Уструшонанинг чўл рустоқларидан бири бўлиб, унинг иқтисодий ва сиёсий тараққиётида стратегик аҳамияти катта. Ёдгорликдан топилган суякдан ясалган предметлар мураккаб тузилишга эга бўлган камон қисмлари бўлиб, бундай камонлар қадимдан ҳарбий ва ов хўжалиги мақсадларида кенг ишлатилиб келинганлиги ҳамда улар бир неча таркибий қисмлардан ташкил топган бўлиб, камоннинг асоси ёғочдан, икки елкаси, яъни эгилиб тортадиган қисми ва қорин қисми пай елими билан ёпиштирилган ҳайвон шохидан ясалган. Бундан ташқари, бу ердан топилган мураккаб таркибга эга камон қолдиқлари ва пайкон учлари илк ўрта асрларда бу ҳудудда яшаган аҳолининг жанговор қуроллари, уларни ясаш ва қисман ҳарбий фаолияти ҳақида маълумотлар келтириб ўтилган.
СЎНГАК МОЗОРҚЎРҒОНИДАН АНИҚЛАНГАН S-ШАКЛИДАГИ ҚАНТАРМА ВА СУВЛУҚ ХУСУСИДА
Authors: Муродалиев Рахмонали
Published: February 2025

Мақолада Сўнгак мозорқўрғонидан аниқланган қўш қантармали сувлуқ ҳақида батафсил маълумотберилган бўлиб, сувлуқ ва қантарманинг пайдо бўлиши ва шаклланиши масалалари ҳам ёритилган.Отнинг устида уни бошқариш ва назоратда сақлашнинг асосий воситаси сифатида илк кўчманчилардавридаёқ оммалашган бу мосламалар металлсозлик тараққий этиши баробарида такомиллашиб келди.Сувлуқ кўпинча жанговор арава ва эгар каби муҳим бўлган. Унинг ёрдамида қуролланган чавандозжанг пайтида мувозанатни сақлаб қолиш эҳтимоли кўпроқ бўлган. Бу эса от устидаги чавандознингуловни ўз вақтида назорат қилишини таъминлаган. Турк хоқонлиги даврига келиб эса темирдан ясалганот анжомлари темирчиликда моҳир саналган туркларнинг ишлаб чиқаришдаги муҳим тармоғи сифати-да ривож топди. Хоқонликка стратегик жиҳатдан муҳим бўлган Чочнинг тоғли ҳудудларида кўчманчива қўнар-кўчар чорвадор халқлар қадимдан ёнма-ён яшаган. Бу ҳудудда эрамизнинг I минг йиллигиўрталарида урбанизация жараёнининг юксалиши билан бирга кўчманчи халқларнинг тоғли минтақа-ларда кенг ёйилиши ва маълум қисмининг ўтроқлашув жараёни кузатилган. Тоғли ҳудудлардан бу кабиот анжомларининг топилиши эса қўшинининг асосини отлиқлар ташкил қилган Турк хоқонлигинингвоҳадаги фаоллиги борасидаги масалаларни ёритишга имкон беради.
SAZOG‘ON-3 NEOLIT MAKONI SAZOG‘ON MADANIYATI YODGORLIKLARI TIZIMIDA (MADANIY-DAVRIY, TIPOLOGIK TAHLIL, TEXNOLOGIYA)
Authors: Xolmatova Zarifa
Published: February 2025

Mazkur maqolada 0 ‘rta Zarafshon vohasi Qoratepa tog‘ tizmasi shimoliy yon bag'rida joylashgan Sazog‘on-3makoni moddiy madaniyati yoritilishi nazarda tutilgan. Bunda aniqlangan moddiy madaniyatning o‘ziga xosxususiyatlari bilan birga tosh qurollarining tipologik tahlili, yasalish texnikasi, xom ashyosi, ishlov berilishiusullari masalalariga e’tibor qaratilgan. Yodgorlik 2017-yildan buyonN. 0 ‘. Xolmatov rahbarligidagi ilmiy guruhtomonidan tadqiq etilib kelinmoqda. Qazilma ishlari jarayonida 100 dan ortiq tosh artefaktlar, qiziqarli sopol idishparchalari qo‘lga kiritilgan. Garchi, bu materiallar asosida yodgorlik madaniy -davriy talqini borasida dastlabkimulohazalar bildirilgan bo‘lsada, biroq tosh industriyaning o‘ziga xos xususiyatlari, tosh qurollaming tipologiktahlili, ulaming yasalish texnikasi, ishlov berilishi usullari, xom ashyosi to‘g‘risida to'laqonli ma’lumotlarberilmagan. Shu bois, yangi materiallar asosidagi ushbu ma’lumotlar ilmiy muomalaga kiritilishi maqolaningmaqsadi hisoblanadi. Tosh artefaktlar 0 ‘rta Osiyo neolit yodgorliklari, xususan Sazog'on madaniyati yodgorliklarimateriallari kontekstida qiyosiy tahlil etildi. Tip varaqa ishlab chiqildi, tipologik tahlil asosida yodgorlik toshindustriyasining o‘ziga xos xususiyatlari asosida Sazog‘on-3 yodgorliginig madaniy-davriy masalasi haqidagima’lumotlar tizimlashtirildi. Shu asnoda, Sazog‘on-3 makoni materiallari asosida quyidagi ilmiy xulosalamikeltirish mumkin: 1. Sazog‘on-3 yodgorligi kishilik tarixi tosh asri neolit davri jamoalari moddiy madaniyatigategishli makon hisoblanadi. 2. Yodgorlik tosh industriyasining xarakteri, tosh qurollarining tipologik tahlili, toshqurollarining yasalish texnikasi, ishlov berilishi usullari, xom ashyosi ma’lumotlari uni Sazog‘on madaniyatigategishli ekanligini ko‘rsatdi.
O‘RTA OSIYO QADIMGI AHOLISINING HAYOTINI TA’MINLASH TIZIMINITIKLASHDA BIOFAKTLAR
Authors: Xatamova Munira
Published: February 2025

Jahondagi rivojlangan davlatlarda arxeologlar turli ko'rinishda bizgacha yetib kelgan kishilar faoliyatiningsaqlanib qolgan qoldiqlari yordamida o‘tmishdagi turmush tarzini qayta tiklashadi. Bu jarayonda yondashuvfanlararo bo‘lib, turli mutaxassislar - botanik, geolog, ekolog va zoologlaming malakasidan kelib chiqiladi.Qadimgi aholining hayotni ta’minlash tizimini o‘rganishda atrof-muhit bo‘yicha iqlim, hayvonlaming tarqalishi,o‘tmishdagi va bugungi flora, tuproq kabi ma’lumotlar muhimdir. 0 ‘simlik qoldiqlari esa flotatsiya usuli bilanqayta tiklangan yowoyi va madaniy o‘simlik turlari, quruq yerlarda yoki yonib ketgan holda topilgan chinakamurug‘lami o‘z ichiga oladi. Qadimgi kishilaming suyaklaridagi kollagenning barqaror uglerod izotoplariesa o'tmishdagi oziqlanish to‘g‘risida muhim bilimlami beradi. Shunday qilib, o‘tmishda yashagan kishilarjamoasida qishloq xo‘jaligi mahsulotlari va umuman o‘simliklaming roli borasidagi antropologik savollargayechim topishda o'simlik qoldiqlari bo‘lmish biofaktlar qo‘l keladi. Sovet va mustaqillik yillarida izlanuvchilar0 ‘rta Osiyo qishloq xo'jaligi o‘tmishini qayta tiklashda ko‘proq yozma, etnografik va arxeologik manbalargasuyanishgan. Zamonaviy asbob-uskunalar va texnikalar bilan jihozlangan laboratoriyalaming yo‘qligi,G‘arb davlatlari va AQSHdagi singari arxeologiya faniga tabiiy fanlaming eng so‘nggi yutuqlari deyarli jalbqilinmaganligi tufayli 0 ‘rta Osiyo qishloq xo‘jaligi o‘tmishini tiklashda biofaktlar asosiy manba sifatidako‘rilmagan. Shu kungacha barcha arxeobotanik izlanishlar chet ellik izlanuvchilar bilan birgalikda qilinganbo‘lsa-da, biroq haligacha 0 ‘rta Osiyoning mahalliy izlanuvchilari orasidan arxeobotanik mutaxassislar yetishibchiqmadi. Maqolada 0 ‘rta Osiyo bo'ylab bugungacha bajarilgan arxeobotanik izlanishlar va bu boradagi ayrimmuammolarga qisqacha sharh beriladi.
ҚАЛЪАЙИ ЗАҲҲОКИ МОРОН – ЖАНУБИЙ СУҒДДАГИ КЎЧМАНЧИЛАР ШАҲРИ
Authors: Раимқулов Абдисабур
Published: February 2025

Мақолада Жанубий Суғд (Қашқадарё воҳаси) ҳудудида жойлашган Қалъайи Зоҳҳаки Морон, Қаршиқалъаси ва Занжир Сарой ёдгорликлари қадимий кўчманчилар шаҳарлари сифатида кўриб чиқилади.Қалъайи Зоҳҳаки Морон квадрат шаклдаги йирик ёдгорлик бўлиб томонлари 1,5 х 1,5 км бўлган ташқидевор билан ўраб олинган. Унинг ичида томонлари 400 х 400 м бўлган иккинчи мудофаа девори, бумудофаа деворининг ичида эса томонлари 200 х 200 м бўлган биринчи мудофаа девори мавжуд. Улар-нинг ўртасида арк – сарой жойлашган. Муаллифнинг фикрича, Қалаи Зоххаки Морон мил.авв. II асрдаюечжиларнинг пойтахт шаҳри сифатида бунёд этилган. Кейинчалик бу пойтахт Пешаворга кўчирилган.1318–1326 йиллар оралиғида Қарши қалъаси (630 х 630 м) бунёд этилган. У ҳам квадрат шаклида бў-либ, ўртасида сарой жойлашган. Чиғатой улуси даврида бу шаҳар пойтахт мақомида фаолият кўрсатган.1334–1340 йиллар оралиғида яна бир шаҳар – Занжир Сарой (400 х 400 м) қурилган. Унинг ҳам марка-зида сарой мавжуд. Қалъайи Зоҳҳаки Морон, Қарши ва Занжир Сарой Ўрта Осиёнинг ноёб кўчманчи-лар шаҳарлари бўлиб, улар фақат Қашқадарё воҳаси ҳудудида сақланиб қолган.
ЖИЗЗАХ ВОҲАСИНИНГ ТОШ ҚУТИ ҚАБРЛАРИ ТАДҚИҚОТИГА ДОИР
Authors: Тошбоев Фурқат , Мамиров Омон , Тугалов Бобур
Published: February 2025

Ҳозирги вақтда Уструшонанинг бронза даврига оид ёдгорликларини ўрганиш ва материалларни умум-лаштириш масалалари очиқлигича қолмоқда. Шу муносабат билан Уструшонанинг шимоли-ғарбийқисмида қадимги аҳолининг ўрнашув босқичларини аниқлаш учун бронза даврининг дафн иншоот-ларини аниқлаш ва ўрганиш алоҳида аҳамиятга эга. Шуни ҳисобга олиб, 2022 йилда Жиззах воҳасидаархеологик тадқиқотлар олиб борилди. Ушбу мақолада Жиззах воҳасидан топилган 15 та тош қутимозорқўрғонлар ҳақида маълумотлар келтирилган.Желли ғули ҳудудида олиб борилган изланишлар натижасида 20 га яқин мозорқўрғон аниқланди вахаритага туширилди, улар орасидан ҳар бирида биттадан дафн этилган 15 та мозорқўрғон очиб ўрга-нилди. Топилган қабрлар тошли тепаликнинг устида қурилган. Тузилиши жиҳатидан мозорқўрғонлартош билан ўралган тўртбурчак шаклда қути ҳосил қилиниб, усти тошлар билан бекитилган ва пастактош уюмидан иборат бўлган. Дафн иншоотларининг худди шундай қурилиши ва характери Евроосиёчўлларининг Андроново маданияти дафн иншоотлари орасида тўлиқ ўхшашликни топади. Эҳтимол,аниқланган мозорқўрғон гуруҳи Андроново маданияти қабилаларининг Ўрта Осиёга кўчиш йўналшла-ридан бирини акс эттиради.
Meningkatkan Aktivitas dan Hasil Belajar Tema Sahabat Kita Muatan PPKn Menggunakan Model Problem Based Learning, Numbered Head Together, dan Teams Games Tournament di SDN Teluk Tiram 2 Banjarmasin
Authors: Salsabila Salsabila , Asrani Asrani
Published: February 2025

Penelitian ini berfokus pada situasi hasil peserta didik dengan rendahnya aktivitas belajar, bertumpu pada kurangnya kreasi model pembelajaran yang inovatif untuk digunakan guru. Kombinasi Problem Based Learning, Numbered Heads Together and Teams Games Tournament menjadi acuan dalam kajian, menggunakan pendekatan kualitatif dan kuantitati dengan rancang tindakan kelas (PTK) dalam kurun 4 kali pertemuan pada siswa semester genap kelas V SDN Teluk Tiram 2 Banjarmasin yang berjumlah 20 orang. Hasil penelitian ini menunjukkan bahwa aktivitas guru pada pertemuan 1 mencapai kriteria “baik” dengan skor 28, pertemuan 2 mencapai kriteria “baik” dengan skor 33, pertemuan 3 mencapai kriteria “sangat baik” dengan skor 34, danpertemuan 4 mencapai kriteria “sangat baik” dengan skor 36. Aktivitas Siswa pada pertemuan 1 mencapai kriteria “kurang aktif”, pertemuan 2 mencapai kriteria “kurang aktif, pertemuan 3 mencapai kriteria “aktif” dan pertemuan 4 mencapai kriteria “sangat aktif”. Ketuntasan klasikal hasil belajar peserta didik pada pertemuan 1 mencapai 60%, pertemuan 2 mencapai 65%, pertemuan 3 mencapai 85%, dan pertemuan 4 mencapai 90%.  Berdasarkan temuan ini dapat disimpulkan bahwa kombinasi model Problem Based Learning, Numbered Heads Together dan Teams Games Tournament dapat meningkatkan aktivitas dan hasil belajar khususnya pada Tema Sahabat Kita.
Neither “True Being” nor “Cosmic Pyrotechnics”: Dewey’s Naturalistic Metaphysics as Environmental Pedagogy Aid
Authors: Warren Sarah
Published: February 2025

Drawing primarily on John Dewey’s Experience and Nature, but putting his metaphysical commitments into conversation with pedagogical experience, this article asks: how might a Deweyan understanding of nature and our experience within it support environmental progress? More specifically, how might we respect pluralistic relationships with philosophy in the classroom while simultaneously cultivating an understanding of experience that clarifies the embodied nature of our meaning-making within it and the contextual urgencies of today? How might observing the “generic traits of existence” and their particular and qualitative manifestations foster an appreciation for how the natural world acts as wellspring of human values? For Dewey as well as William James, experience is “double barreled,” designating both the “planted field” and “the one who plants and reaps”: functional distinctions serve a purpose, but experience emerges at, and astride the tensional energies that characterize, the permeable boundaries of self and world. Taking Dewey’s insights to heart illuminates how issues like biodiversity preservation are deeply existential concerns that are ripe for a Deweyan pedagogical intervention.
Pratiques enseignantes et ressentis de stress chez les élèves. Exemple dans cinq disciplines scolaires dans le second degré français
Authors: Nakas Raffi
Published: February 2025

Cette recherche vise à déterminer les pratiques pédagogiques ressenties comme les plus stressantes par des collégiens en France. Un échantillon (n = 809) de 395 garçons et 414 filles de 6e et de 3e du niveau collège ont répondu à un questionnaire portant sur les pratiques enseignantes dans cinq matières (mathématiques, français, histoire-géographie, éducation musicale, éducation physique et sportive). Ce questionnaire de comparaison par paires (CPP) est issu de la procédure de Condorcet. Les résultats mettent en évidence les deux facteurs les plus stressants communs à toutes ces disciplines : se produire devant les autres et le fait d’être interrogé par surprise.
A wave of minor de novo DNA methylation initiates in mouse 8-cell embryos and co-regulates imprinted X- chromosome inactivation with H3K27me3
Authors: Yue Yuan , Fu Wei , Yang Qianying , Zhang Chao , Wang Wenjuan , Chu Meiqiang , Lyu Qingji , Tang Yawen , Cui Jian , Wang Xiaodong , Zhang Zhenni , Tian Jianhui , An Lei
Published: February 2025

DNA methylation is extensively reprogrammed during early stage of mammalian development and is essential for normal embryogenesis. It is well established that mouse embryos acquire genome-wide DNA methylation during implantation, referred to as
de novo
DNA methylation, from globally hypomethylated blastocysts. However, the fact that the main
de novo
DNA methyltransferase 3B (DNMT3B) is initially expressed as early as the 8-cell stage, contradicts the current knowledge about timing of initiation of
de novo
DNA methylation. Here, we reported that a previously overlooked minor wave of
de novo
DNA methylation initially occurs during the transition from the 8-cell to blastocyst stage, before the well-known large-scale
de novo
DNA methylation during implantation. Functional analyses indicated that minor
de novo
DNA methylation regulates proliferation, lineage differentiation and metabolic homeostasis of preimplantation embryos, and is critical for embryonic developmental potential and pregnancy outcomes. Furthermore, bioinformatic and functional analyses indicated that minor
de novo
DNA methylation preferentially occurs on the X chromosome and co-regulates imprinted X-chromosome inactivation via the interaction between DNMT3B and polycomb repressive complexes 2 core components during blastocyst formation. Thus, our study updates the current knowledge of embryonic
de novo
DNA methylation, thereby providing a novel insight of early embryonic epigenetic reprogramming.
Management of Diabetic Ketoacidosis Section Complicated by Invasive Systemic Candidiasis in Type 1 Diabetic Patient: A Case Report
Authors: Yadav Ponvijaya M , Giduturi Vineetha Naga Lakshmi , Mishra Mahabir Prasad , Singh Divam Prakash , Gokhale Vijayashree S
Published: February 2025

Diabetic Ketoacidosis (DKA) is a severe metabolic complication commonly associated with Type 1 Diabetes Mellitus (T1DM), characterised by hyperglycaemia, metabolic acidosis and ketonaemia, leading to significant morbidity and mortality if not promptly treated. Invasive systemic fungal candidiasis, caused by Candida species, is a critical opportunistic infection that can complicate DKA. This case report discusses a patient with type 1 diabetes who developed DKA, which was subsequently complicated by invasive systemic fungal candidiasis and multiorgan dysfunction. A 19-year-old female patient presented with complaints of vomiting, dyspnoea on exertion, swelling of the vagina, and left hypochondriac pain for two days. The patient had T1DM for two years and had missed her insulin doses, after which she developed DKA along with a vaginal Bartholin’s cyst that tested positive for fungi. She went into sepsis and septic shock. Subsequently, this developed into Multiple Organ Dysfunction Syndrome (MODS) after initially presenting as a local illness and then spreading to systemic invasive fungal candidiasis. The patient ultimately succumbed to the illness following a protracted stay in the Intensive Care Unit (ICU), despite receiving larger doses of antibiotics and antifungals, undergoing tracheostomy and mechanical ventilation, and having returned of spontaneous circulation, repeated Cardiopulmonary Resuscitation (CPR) cycles, as well as support from inotropic agents and vasopressors. This case highlights the necessity of early diagnosis and intervention with prompt action to prevent delayed diagnosis and complications that may arise. Serum 1,3 Beta-DGlucan was positive, while Galactomannan was negative. Blood cultures were positive for Klebsiella pneumoniae. A vaginal swab culture from the Bartholin cyst revealed Candida albicans with pseudohyphae and budding yeast cells.
Intense Physical Exercise Reduces Complications, Hospitalizations and Potential Mortality from Covid-19
Authors: Silva Romeu Paulo Martins , Silva Fabio Nascimento da , Pernambuco Carlos Soares , Moreira Marcelo Hubner , Dantas Estélio Henrique Martin , Höekelmann Anita , Bianco Gianluca , Vitoria Cesar Rodrigo Vargas , Pardo Pablo Jorge Marcos , Leal Silvânia Matheus de Oliveira , Lopes Tomires Campos , Bessa Artur , Scudese Estevão , Mohammadi Hossein , Soares Bem Hur , Scartoni Fabiana Rodrigues , Guimarães Andrea Carmen , Maia Brisa D’Louar Costa , Costa Odelio Joaquim , Bezerra Jani Cleria Pereira , Santos Cesar Augusto de Souza , Ribeiro Domingos Edno Castro , Borges Eliane Gomes Silva , Ferreira Daniel Tobelém Maués , Bello Maria de Nazaré Dias , Tiago Allan Carlos da Silva , Furtado-da-Silva Vernon , Souza Divaldo Martins de , Carvalho Mauro Cesar Gurgel de Alencar , Valentim-Silva João Rafael
Published: February 2025

Aims: The present study investigate the relationship between pre-COVID-19 exercise levels and intensity and disease outcome. Methodologically we used an online survey comprising 20 questions was sent to participants to determine their exercise history, including type, intensity, and exacerbation of COVID-19 symptoms.
Study Design: A populational survey-based study.
Place and Duration of Study: A multicentric with many institutes and universities from Germany, Chile, Iran, Italy, Spain, Unted Staes of America, Canadá and Brazil. The duration from 2020 until 2024.
Methodology: A large survey to determinate the physical fitness level, type, duration, and intensity of the physical exercise was applied under invitation of many associated researchers around the world. A electronic version were used to improve the acquisition in partners health centers and universities. We analyzed the possible interactions using a chi-square test to infer the results.
Results: We note that individuals physically active had significantly better disease outcomes than physically inactive individuals. Low or moderate-intensity exercise did not show significant differences in exacerbations, but high-volume or high-intensity exercise was associated with decreased complications requiring hospitalization.
Conclusion: Our study concludes that physical activity reduces the risk of intensive care and hospitalization due to SARS-CoV-2 infection, and exercise intensity plays a crucial role in mitigating the severity of the disease. The study suggests that a more physically active world population could prevent many deaths associated with COVID-19, and save life.
Algae Biofilm Produced from Anaerobic Digester Wastewater Demonstrated as Biofertilizer for Dwarf Wheat
Authors: Watson Pascal , Sims Ronald C.
Published: February 2025

Aims: To correlate yield of dwarf wheat fertilized with algae biofilm produced using anaerobic digester effluent (digestate) from a municipal water resource recovery facility as nutrient source and compare with yield using non-algae biofilm based fertilizers and a negative control.
Study Design: Greenhouse testing for measurement of biomass yields and statistical analysis of wheat yield data results. 
Place and Duration of Study: Department of Biological Engineering Algae Processing and Products Facility greenhouse between March and June, 2024.
Methodology: Yield of a dwarf cultivar of red spring wheat was measured as a function of four treatments including three fertilizers and a negative control: (1) algae biofilm cultivated on anaerobic digester effluent, (2) positive control of Osmocote commercial slow release fertilizer, (3) anaerobic digester biosolids, and (4) negative control with no fertilizer addition.
Results: Average yield values (gm) for the four treatments were: (1) 1.25, (2) 0.99, (3) 0.72, and (4) 0.52, respectively. Algae biofilm fertilizer performed significantly better than Osmocote with P = .002, anaerobic digester biosolids with P = .05, and no fertilizer addition with P = .05. Struvite, a slow release fertilizer, was observed to be associated with the algae biofilm as a precipitate of the high concentrations of nutrients within the anaerobic digester water.  Struvite (MgNH4PO46H2O) releases plant available nitrogen and phosphorus over time and is biologically precipitated due to the increase in solution pH as a result of photosynthesis by the algae biofilm.
Conclusion: Algae biofilm cultivated on anaerobic digester wastewater can serve as a biofertilizer for recycling nutrients within the biosphere for sustainable nutrient management.
Bicuspid valve CT registry of balloon‐expandable TAVR: BETTER TAVR registry
Authors: Chavarria Jorge , Falcao Felipe , AlRaddadi Hatim , Aziz Amir , Dick Alexander , Chung Kevin , Meier David , Sathananthan Janar , Ali Noman , Um Kevin John , Velianou James , Natarajan Madhu , Jaffer Iqbal , Wood David , Fam Neil , Sheth Tej
Published: May 2024

Background

The anatomic substrate of bicuspid valves may lead to suboptimal TAVR stent expansion and geometry.

Aim

We evaluated determinants of stent geometry in bicuspid valves treated with Sapien transcatheter aortic valve replacement (TAVR) valves.

Methods

A multicenter retrospective registry of patients (February 2019 to August 2022) who underwent post‐TAVR computed tomography to determine stent area (vs. nominal valve area) and stent ellipticity (maximum diameter/minimum diameter). Predictors of relative stent expansion (minimum area/average of inflow + outflow area) and stent ellipticity were evaluated in a multivariable regression model, including valve calcium volume (indexed by annular area), presence of raphe calcium, sinus diameters indexed by area‐derived annular diameter, and performance of pre‐dilation and post‐dilation.

Results

The registry enrolled 101 patients from four centers. The minimum stent area (vs. nominal area) was 88.1%, and the maximum ellipticity was 1.10, with both observed near the midframe of the valve in all cases. Relative stent expansion ≥90% was observed in 64/101 patients. The only significant predictor of relative stent expansion ≥90% was the performance of post‐dilation (OR: 4.79, p = 0.018). Relative stent expansion ≥90% was seen in 86% of patients with post‐dilation compared to 57% without (p < 0.001). The stent ellipticity ≥1.1 was observed in 47/101 patients. The significant predictors of stent ellipticity ≥1.1 were the indexed maximum sinus diameter (OR: 0.582, p = 0.021) and indexed intercommisural diameter at 4 mm (OR: 2.42, p = 0.001). Stent expansion has a weak negative correlation with post‐TAVR mean gradient (r = −0.324, p < 0.001).

Conclusion

Relative stent expansion ≥90% was associated with the performance of post‐dilation, and stent ellipticity ≥1.1 was associated with indexed intercommisural diameter and indexed maximum sinus diameter. Further studies to determine optimal deployment strategies in bicuspid valves are needed.
Enhanced Organocatalytic Processes through an Engineered Acid‐Base Site Bifunctional Pore in a Zirconium Metal‐Organic Framework
Authors: Moreno José María , Gil‐San‐Millan Rodrigo , Mas‐Ballesté Rubén , Alemán José , Platero‐Prats Ana E.
Published: May 2024

This work introduces a robust acid‐base catalytic system based on the zirconium‐based metal‐organic framework (Zr‐MOF) MOF‐808, selected for its open structure, high stability, and low presence of structural defects compared to other Zr‐MOFs. Four bifunctional benzoate ligands bearing free carboxylic acid (‐COOH) and nitrogen‐containing groups were introduced into the MOF‐808 using solvent‐assisted ligand exchange methods. Unlike other materials, the acid and base sites in the bifunctional MOF‐808 materials are situated in the same capping ligand, leading to a bifunctional behavior between the two neighboring sites. The system was tested for Knoevenagel condensation and deacetylation‐Knoevenagel tandem reactions, demonstrating high catalytic activity and excellent yields. Additionally, computational modeling provided insights into the catalytic mechanism and the role of the acid‐base sites. The study provides a better understanding of the unique behavior of the bifunctional MOF‐808 catalyst and offers prospects for designing new and efficient catalytic systems for organocatalysis.
Palladium‐Catalyzed Selective Syntheses of 2,3‐Allenyl Amines via Double Functionalization Coupling of 2‐Alkynyl‐1,4‐diol Dicarbonates
Authors: Zhou Zhengnan , Li Can , Ma Shengming
Published: May 2024

Comprehensive Summary

2,3‐Allenyl amines have shown wide applicability in biomedical and synthetic applications. Due to their enormous potential for applications, researchers have been dedicated to the development of methods for synthesizing 2,3‐allenyl amines. Herein, a palladium‐catalyzed three‐component reaction of 2‐alkynyl‐1,4‐diol dicarbonates, organoboronic acids, and nitrogen nucleophiles forming 2,3‐allenyl amines with excellent regio‐ and chemo‐selectivity has been developed. Substrate compatibility and synthetic applications have been demonstrated. Control experiments supported a mechanism involving 1,2,3‐triene‐Pd species and methylene‐π‐allyl palladium species.
Calcium Carbide (CaC2) as a C2‐Synthon by Mechanochemistry
Authors: Cortés‐Lobo Alejandro , Hernández José G.
Published: May 2024

Mechanochemical reactions by ball milling have opened new avenues in chemical synthesis. Particularly, mechanochemistry has facilitated the reaction of insoluble materials to simplify stablished synthetic protocols and develop new ones. One notable application involves the use of calcium carbide (CaC2) as a C2‐synthon through mechanochemistry, which has offered a more practical alternative to incorporate C2‐units compared to the conventional use of highly flammable gaseous acetylene. For example, by ball milling, the acetylenic anions [C2]2− found in CaC2 have been harnessed for the synthesis of diverse functional carbon materials as well as discrete organic molecules. This Concept aims to contribute to the conceptualization of this innovative approach while highlighting both its advantages and the challenges inherent in the use of CaC2.
Account of eco‐friendly energy conversion reaction: Iron‐based nitrogen electrofixation
Authors: Xu Liyuan , Zhu Zheng , Duan Jingjing , Chen Sheng
Published: May 2024

Ammonia is a crucial raw ingredient used in the manufacturing of fertilizers and pharmaceuticals, which are major sectors of the national economy in the chemical and agricultural industries. The conventional Haber–Bosch method is still in use in the industry today to manufacture NH3, and the production process emits a significant quantity of CO2, which does not match the current standards for the achievement of carbon neutrality. The nitrogen reduction reaction (NRR) technology has garnered a lot of attention lately because of its benefits, which include being environmentally friendly, sustainable, and able to function in mild environments. However, NRR is still in its early stages of development and confronts numerous difficult issues, including slow reaction kinetics, low ammonia yield rates and Faradaic efficiency (FE), and a dearth of effective research on nitrogen fixation as a whole. This paper aims to promote the industrialization of NRR, summarizing the progress of iron‐based catalysts, including single atomic catalysts, organic frameworks, metal oxides the, and alloys. Eventually, this paper discusses the strategies for improving NH3 yield rates and FE, improving reaction kinetics, and building a sustainable overall nitrogen fixation system. The development of iron‐based catalysts in other fields has also been prospected.
Clinical performance of a prefabricated immunofluorescence assay for nasopharyngeal cancer screening
Authors: Chen Vanessa Hui En , Ong Lizhen , Teo Wei Keat , Siow Chor Hiang , Goh Han Lee , Tan Charmaine , Lim Wei Sian , Eu Donovan , Cheong Ian S. Y. , Chan Soh Ha , Loh Kwok Seng , Tay Joshua K.
Published: May 2024

Background

Epstein–Barr virus (EBV) IgA serology for viral capsid antigen (VCA) and early antigen (EA) aids early detection of nasopharyngeal cancer (NPC), resulting in improved survival. We evaluated the diagnostic performance of a prefabricated immunofluorescent assay (IFA) for NPC screening in high‐risk individuals.

Methods

Sera from 96 biopsy‐proven patients with NPC diagnosed at the outpatient clinic and 96 healthy family members were tested for EBV‐VCA IgA and EBV‐EA IgA using the prefabricated IFA from EUROIMMUN (EI) and the traditional immunofluorescence method.

Results

The AUC of EI EBV‐VCA IgA and EBV‐EA IgA was 0.907 (95% confidence interval [CI]: 0.894–0.965) and 0.898 (95% CI: 0.848–0.947), respectively. Combined testing with the prefabricated assay at a threshold of VCA ≥1:320 or EA ≥1:10 showed 92.7% sensitivity and 81.2% specificity. Overall, the traditional EBV‐EA IgA assay demonstrated the best accuracy (sensitivity 91.7% and specificity 96.9%) at a threshold of ≥1:5.

Conclusion

While the traditional IFA method was more accurate, the prefabricated IFA test kit can be a useful tool for NPC screening in high‐risk populations.