bluuebunny/crossref_metadata_2025 huggingface dataset:
Swimming Exercise Management on Jaka Utama SC Lampung Club in the Covid-19 Pandemic
Authors: Putri Anita Herdiana , Cahyadi Ardian , Sitepu Akor , Husein Sudirman , Utama Dimas Duta Putra
Published: November 2022

This study aims to determine the training management of the Jaka Utama SC Lampung swimming club during the covid-19 pandemic. The research was conducted using a descriptive qualitative survey method. Research data collection is carried out in natural conditions and primary data sources. The subjects used in this study were 12 subjects, including the Jaka Utama swimming club, two administrators, two coaches, four parents and four swimmers at Club Jaka Utama SC Lampung. This study uses a qualitative descriptive method with the research instrument based on observation, interviews and documentation. The research results explained that the Club Jaka Utama organization was running as it should during the covid-19 pandemic because the organizational and administrative systems were still simple and in the process of implementation, still complying with health protocols. The management system is unprofessional, with some administrators holding concurrent positions in the management structure. Coordination between administrators is natural following the circumstances. The training management at Club Jaka Utama SC Lampung has adapted to the conditions during the covid-19 pandemic, the organizational condition of Club Jaka Utama SC Lampung is not going well, and the management system has not undergone regular reorganization. Reports for athletes are carried out directly by the administrators and coaches; parents accompany children in training so that they witness the training process given.
Validation of Soccer Shooting Skills Test in Junior High School Students
Authors: Widodo Achmad , Wismanadi Himawan , Wahyudi Heri , Fikri Muhammad Dzul , Firmansyah Awang
Published: November 2022

The purpose of the study was to develop a test instrument of shooting skill that is valid and reliable on junior high school soccer students (13-15 years) as many as 33 subjects. The approach of this type of research is the development, the sampling using purposive sampling method that has the criteria of Junior High School students aged 13-15 years (male) who are hobbyists and proficient in soccer. The results of the test validity test showed that the level of validity of the instrument shooting skills test on right and left foot 0.89 with perfect category, and has a reliability value of R = 0.78 (medium), left r = 0.83 (high). The conclusion of this study is that the instrument tests of shooting skill with the closest distance to the goal of 15m using the right and left limbs have a level of validity that meets the standards. Thus the instrument tests of shooting skill can be used to measure and assess the technical skills of playing kicking the ball into the football goal at the junior high school level (13-15 years).
Developing Variety of Handball Attacking Strategies Training for Malang Handball Athletes
Authors: Hadi Antonius Prasetyo , Mustofa Habibullah , Lufthansa Luthfie
Published: November 2022

The research aims to develop learning media products as a reference book to improve handball athletes in Malang city's attack strategy techniques. The method used in this research is the development method (Research and Development) from Brog and Gall. In this development of the research, a reference book was produced on variations of an attack training strategy for Handball athletes in Malang. The research results of the analysis data from the Analysis Expert of handball training with a value of 4,03 on a scale of 1 to 5 with a good predicate, the results of validation by the Expert of media with a value of 4,22 on a scale of 1to 5 with a good prediction. The research results from the first phase trial showed a small group with a percentage of 7,43%, the research results in the second phase trial with a percentage of 78,57%, and in the field trial, a percentage of 83,33% was obtained. Based on the results of management data, the developed book product was declared fit for use as a learning media for attack training strategy of variation for handball athletes in the city of Malang.
The Effect of Animation Teaching Materials on Soccer Game Tactics and Strategies Knowledge
Authors: Faizal Faizal , Firdausi Dzihan Khilmi Ayu , Andriadi Andriadi
Published: November 2022

This test is motivated by the problem of student learning outcomes, especially information about soccer strategies and tactics which are still relatively low. The motivation behind this review is to determine the impact of animation on knowledge of the strategy and tactics soccer games on 12th grade Pangkalpinang Senior High School 3. This test provides a reference for educators in expanding student information. This research is an experimental quantitative research. Determination of the sample by purposive sampling procedure. The sample used is 32 students. This experiment uses a Pre-Experimental Design with a trial plan of the One Group Pretest-Posttest Plan. The data testing method used One Sample t-test (Pretest-Posttest). After testing the presumption using the t-test, it is obtained that tcount = 3.893 and ttable with a degree of 5% = 1.696, then Ha is recognized and H0 is rejected. Thus, it can be concluded that there is an effect of animation teaching materials on the knowledge of strategy and tactics soccer game on 12th grade Pangkalpinang Senior High School 3.
Survey of Student Interest in Participating in Physical Education Learning at MAN 1 Malang
Authors: Amiq Fahrial , Mutohir Toho Cholik , Suroto Suroto , Saputro Yulianto Dwi
Published: November 2022

The purpose of this study was to determine the interest of students in participating in the learning of Physical Education, Sports, and Health at MAN 1 Malang. The method used is a survey, the data collection technique uses a questionnaire, and the scores obtained from the questionnaire are then analyzed using descriptive and quantitative analysis as outlined in the form of percentages. The sample used in this study were students of MAN 1 Malang class X-XII, with a total of 90 students. Sample selection was made by using a simple random sampling technique. The data analysis technique used in this study is the analysis of prerequisite tests, namely validity tests (instruments) and reliability tests. Based on the results of data analysis, it can be found that the results of students' interest in participating in Physical Education, Sports, and Health learning at MAN 1 Malang are in the high category with the highest frequency consideration, as many as 36 students or 40%. The results of infrastructure facilities on student interest in participating in Physical Education, Sports, and Health learning at MAN 1 Malang are in the high category, namely as many as 36 students or 40%. Based on the results of the study, it can be concluded that the student's interest in participating in the learning of Physical Education, Sports, and Health at MAN 1 Malang is in the high category. Meanwhile, judging from the factors of facilities and infrastructure on students' interest in participating in the learning of Physical Education, Sports, and Health at MAN 1 Malang is in the high category.
The Role of Schools and Physical Education in Supporting Sports Achievement: Literature Review
Authors: Dahlan Firmansyah , Mahyuddin Reza , Muslim Muslim
Published: November 2022

The Great Design of National Sports (DBON) of the Republic of Indonesia has been ratified, invited, and socialized. The urgency in succeeding the Law is the synergy of all parties. The question that arises is, “how is this synergy built?”. For this reason, this literature review is directed to describe the synergies (positions, roles, and benefits) of schools (extracurricular sports and Physical Education) related to achievement sports that are disseminated in scientific journals. Databases used are; Sinta, google scholar, sciencedirect.com, springer, the Mendeley application, VOSviewer, and Publish or Perish. Results; 1) Schools are strategic places to promote achievement sports. 2) Physical education plays an important role in the mass and nursery stages. 3) Achievement sports have many benefits for children, but with a clear reference that is not for all children. 4) Important factors for the development of achievement sports in schools are an appropriate curriculum, run by professionals, adequate networks, parents, and government commitment. 5) Associations/ federations and sports clubs provide experts and staff, the government provides sports facilities, and Physical Education teachers and students become the subject of the development. 6) Sport and physical education extracurricular activities have a positive influence on children’s academic abilities (indirectly) because children are happy and feel at home in school, which increases their self-confidence and self-esteem. 7) Extracurricular sports do not interfere with children’s academic achievements when carried out properly.
Analysis of the Results of Basic Life Support and First Aid Training for Soccer School Coaches in East Java
Authors: Arisanti Shinta , Pribadi Florence , Santoso Rahajoe Imam , Lifindra Bella Meylani , Kencanawati Nathania Dwi
Published: November 2022

The Provincial Association of All-Indonesian Football Associations in East Java as the Association of Football Associations, has duties and responsibilities in managing, developing and advancing East Java football. One of the problems faced by the Provincial Association is the first treatment of sports injuries. New football coaches receive training on Basic Life Support and First Aid for injuries/traumas when participating in C-licenced trainer certification while becoming a coach at a football school does not require a C-licence qualification. The purpose of this study was to determine the skills and abilities of football coaches regarding Basic Life Support and First Aid for injuries to players when the medical team is not available so that permanent disability and athlete death can be avoided. The method used is a survey method by assessing the skills of Football School coaches in understanding Basic Life Support and First Aid. The results show that only 12 have heard/done 38.7% of First Aid training. Of the 31 coaches, 18 people understand what to do to check consciousness when a player faints are 58.1%. How to free the airway in players suspected of having neck injuries, only 13 coaches knew about 41.9%. Only 12 coaches knew how to free the airway in players without neck injuries by 38.7%. 15 trainers who know the maximum time for breathing examinations are 48.4%.
Effect Combination of HIIT with Recovery Model on VO2max Quality and Monitoring of Heart-Rate Recovery
Authors: Kurniawan Candra , Priyono Dwi , Firmansyah Guntur
Published: November 2022

This study aims to analyze the effect of differences resulting from the combination of HIIT with recovery models in active and passive forms on the quality of VO2max and monitoring of heart-rate recovery. This study was designed using a quasi-experimental design, and 30 participants participated voluntarily in the study which was further divided into three groups: HIIT-PP experiment (n:10; Age: 21.0±0.82; Weight: 67.2±13.6; Height: 1.68±0.07), HIIT-PP experiment (n=10; Age: 21.1±1.20; Weight: 64.9±6.07; Height: 1.68±0.04), and control group (n=10; Age: 21.09±1.29; Weight: 69.3±5.46; Height 1.69±0.05). This research instrument uses Multistage Fitness Test (MFT) and Heart-Rate Monitoring. The procedure for analyzing the statistical research data used the Analysis of Variance (ANOVA) test with a p-value <0.05. The results showed that the parameter differences between the experimental and control groups significantly improved the quality of VO2max and monitoring of heart-rate recovery (HRM, and HRR 2min, 5min, 10min). This study can conclude that using HIIT with recovery models in passive forms for eight weeks resulted in a change in the quality of VO2max and monitoring of heart rate recovery.
Inclusion of Students with Disabilities in a Socio-Cultural Perspective: What is the Perception of Physical Education Teachers?
Authors: Sari Merlina , Risma Nova , Gazali Novri , Rodia Nurafni
Published: November 2022

This study aims to examine teachers' perceptions of inclusive physical education in Pekanbaru City and the identity of the factors that influence their perceptions from a socio-cultural perspective. This research is qualitative. The research subjects recruited were physical education teachers in Pekanbaru City. The selection of participants is based on two criteria: (i) teachers who have earned a Bachelor's degree in Physical Education and (ii) teachers who teach students with disabilities in public and private junior high schools. Based on these criteria, only five physical education teachers were found. Individual interviews were conducted with each teacher. Deductive and inductive analysis processes are used to organize and report the data. The results showed that teachers believed general physical education classes were a good place to develop students with disabilities. Teachers realize that students with disabilities can have equal opportunities to participate in general physical education programs and develop social skills. Although the teachers recognized these benefits, they also expressed concern about the instructional and environmental barriers to the inclusion of students with disabilities in mainstream sports programs. Future research should address the importance of teachers' beliefs and practices about effective teaching in inclusive.
Analysis of Physical Activity in Atoni Meto Traditional Sports on North Central Timor Regency
Authors: Talan Rudobertus , Nay Florianus Aloysius , Andiwatir Alexius
Published: November 2022

The purpose of the study was to determine the physical activity and traditional sports of Atoni Meto in North Central Timor Regency. The initial stage of the research method is that researchers develop research instruments that will be used to explore information from sources in depth through direct observation (observation), in-depth interviews, focus grup discussion, and documentation studies to find physical activities and traditional sports Atoni Meto "Mantika" in North Central Timor Regency. In the data analysis process, the research team was based on the Miles and Huberman analysis model: data collection, data reduction, data presentation, and conclusion drawing (verification). The results showed that the physical components contained in the traditional Atoni Meto sport in North Central Timor Regency were the values ​​of sportsmanship, endurance, strength, coordination, balance, and accuracy. Some of these sports components can be integrated into the learning process of Physical Education in Sports and Health at the elementary, middle, and high school levels.
The Effectiveness of Lateral Hop and Leg Press Training on Limb Strength and Explosive Power for Athletes
Authors: Nurrochmah Siti
Published: November 2022

The aim of the study was to examine the effectiveness of fast lateral hop (LHC), slow lateral hop (LHL) and leg press (LLP) training on increasing the strength and explosive power of the leg muscles simultaneously. The approach method is in the form of an experiment using a Randomized Pretest-Posttest Control Group Design. The sample is 51 people divided into three groups using the ordinal pairing matched technique. Data were obtained using test and non-test instruments and collected using experimental techniques, observation and physical condition tests. Data analysis using one-way Manova technique Hotelings Trace method. The results of the analysis found that the F test = 25,413 and the significance of F = 0.000 < 0.05, meaning that LHC, LHL and LLP training were effective in increasing the strength and explosive power of the leg muscles simultaneously. The results of the Between-Subjects Effects analysis in the form of partial eta squared variation KOT 15.6% and variation DEOT = 63.4%. The conclusion of the study was that there was a significant effect of LHC, LHL and LLP training on increasing the strength and explosive power of the leg muscles simultaneously. LLP training is more effective in increasing leg muscle strength, and LHC training is more effective in increasing the power of leg muscles.
Contemporary Drug-Eluting Stents and Vascular Response
Authors: Habib Anwer , Mori Hiroyoshi , Yahagi Kazuyuki , Finn Aloke V.
Published: December 2022

Cardiovascular disease is a leading cause of death and disability worldwide. Current treatment strategies aimed at treating the consequences of coronary artery disease have embraced both optimal medical therapy and catheter based percutaneous coronary intervention with drug-eluting stents (DES). Current-generation DES elute predominantly mammalian target of rapamycin (mTOR) inhibitors, which act primarily as a cytostatic agent that retards vascular smooth muscle cell proliferation and migration; this occurs in response to injury and thus prevents restenosis. While DES have reduced restenosis, the use of first-generation DES was associated with an increased risk of late stent thrombosis and accelerated neointimal atherosclerosis (i.e. neoatherosclerosis), both major contributors to late stent failure. The underlying substrate of late DES failure is likely related to vascular endothelial dysfunction, which occurs after DES implantation. Initial concerns with first-generation DES have led to improvements in stent design, polymer load and biocompatibility, and pharmacologic agents, all of which have helped to improve healing responses, lessen late stent failure, and result in an overall improved safety profile. The armamentarium of DES has expanded from the current-generation durable polymer DES to bioresorbable polymer DES, polymer-free DES, and lastly totally bioresorbable vascular scaffolds with a goal of improving vascular responses and endothelial function while preserving anti-restenotic efficacy. We will review these contemporary DES in relation to their short and long-term effects on vascular biocompatibility and healing responses.
Reading Pieces
Authors: Kamuf Peggy
Published: December 2022

These are three pieces on reading (‘surface reading’, teaching and learning to read) that take lessons from Flaubert, Derrida, Billy Collins and Rousseau.
Analysis of drug prescriptions of patients with atrial fibrillation in combination with chronic kidney disease for compliance with STOPP/START criteria
Authors: Shatalova N. A. , Batyukina S. V. , Chernyaeva M. S. , Kochetkov A. I. , Ebzeeva Ye. Yu. , Ostroumova O. D.
Published: November 2022

The percentage of elderly and senile patients is growing every year. Among this cohort of patients, atrial fibrillation (AF) is one of the most common rhythm disorders. At the same time, AF repeatedly increases the risk of thromboembolic complications. The course of AF in elderly patients is often complicated by chronic kidney disease (CKD). When managing patients of this group, we often encounter polypragmasia, which affects the patient’s quality of life, increases the risk of falls, and potentially reduces life expectancy. In order to optimize pharmacotherapy, STOPP/ START criteria were developed.

The purpose of the study was the analysis of drug prescriptions in patients over 65 years of age with AF and CKD for compliance with the STOPP/ START criteria.

Material and methods. 339 case histories of the cardiology department and 180 case histories of patients of the therapeutic department of the Veterans of Wars multidisciplinary hospital were analyzed. In each department, patients were divided into 2 groups: patients with AF in combination with CKD C3a and patients with AF in combination with CKD C3b and C4.

Results. In the therapeutic department, 96.1% of the first group and 100.0% of the second group of patients were not prescribed drugs that are recommended for elderly patients (START criteria). 64.7% of patients from the first group and 53.8% of patients from the second group have potentially not recommended, but prescribed drugs (STOPP criteria) in the appointment lists In the cardiology department, the percentage of patients who did not have the recommended drugs (START criteria) in drug therapy was 92% in group 3, 97% in group 4. The percentage of patients who were prescribed potentially non-recommended drugs (STOP criteria) in group 3 45%, in group 4 48%.

Conclusion. Most elderly and senile patients with AF in combination with CKD have both START and STOPP criteria, which dictates a thorough analysis of the prescribed drug therapy.
Features of metabolic disorders in centenarians
Authors: Topolyanskaya S. V. , Eliseeva T. A. , Turna O. I. , Vakulenko O. N. , Romanova M. A. , Dvoretski L. I. , Rachina S. A. , Lytkina K. A. , Melkonyan G. G.
Published: November 2022

Aim: to study the features of purine, lipid and carbohydrate metabolic disorders in patients with coronary artery disease over 90 years old (centenarians).

Materials and methods. The study enrolled 225 patients over 90 years, hospitalized with coronary artery disease. The majority of patients (67.6%) were women. The mean age of the patients reached 92.5+2.2 years (from 90 to 106 years).The blood levels of uric acid, lipids, glucose and body mass index were determined.

Results. Obesity was registered in 31.5% of patients, grade III obesity – in 1 patient. Overweight was observed in 39.1% of patients, normal body mass index (BMI) – in 28.9%. An increase in the blood concentration of triglycerides was determined in 11.2% of patients. A decrease in the level of high-density lipoprotein (HDL) cholesterol was registered in 12.7% of patients. The blood concentration of low-density lipoprotein cholesterol (LDL) less than 2.0 mmol/l was observed in 23.3% of cases. Dyslipidemia was registered more often in women (p=0.02). Hyperuricemia was found in 37.3% of patients – in 41.4% of women and 28.8% of men (p=0.04). Elevated fasting blood glucose levels were determined in 23.1% of patients, but only 0.9% of patients had glucose levels above 14 mmol/l.

Conclusion. The study results indicate some features of metabolic disorders in centenarians with coronary artery disease. Most of the patients were obese or overweight. Frequent hyperuricemia was registered, but relatively low levels of atherogenic lipids and glucose.
The role of exogenous melatonin in the regulation of sleep
Authors: Orlova S. V. , Nikitina E. A. , Balashova N. V. , Pigareva Yu. A. , Ankvab E. V. , Khadzhimuratova T. I.
Published: November 2022

Melatonin is a natural hormone produced by the pineal gland and is a derivative of serotonin. One of the key properties of melatonin is its chronobiological ability, realized by multilevel synchronization of biological processes. Physiologically, melatonin secretion increases at night and decreases in the morning. At present, the role of melatonin in the regulation of sleep, circadian rhythms, and adaptation of the body to a rapid change in time zones has been proven. With a decrease in the production of endogenous melatonin in a number of people (with a disorder of daily biorhythms due to long-distance flights, shift work, insomnia), the use of exogenous melatonin improves the quality of sleep.
Endocrine disorders associated with COVID 19. Adrenal insufficiency
Authors: Orlova N. V. , Pecherskikh A. A. , Cherenkova E. N. , Zhuravleva M. S.
Published: November 2022

COVID‑19 has a negative impact not only on the respiratory system, but also on other organs and systems, including the endocrine. Cases of lesions of the hypothalamus, pituitary gland, thyroid gland, adrenal glands, gonads and pancreas are described. Hypocorticism in COVID‑19 patients can be caused by various reasons: damage to the adrenal endothelium, bilateral hemorrhages and heart attacks. Adrenal insufficiency in patients with COVID‑19 can have a negative impact on the prognosis of coronavirus infection. A clinical case of primary adrenal insufficiency is presented. The patient was hospitalized three times within 2 months with complaints of dyspeptic phenomena, weight loss. A sharp increase in complaints was noted after the transferred COVID‑19. The diagnosis of adrenal insufficiency was assumed after the appearance of a specific brown color of the skin. Hypocorticism has been confirmed in the laboratory. Cases of primary adrenal insufficiency after COVID‑19 can cause difficulties in diagnosis, because clinical manifestations are similar to the phenomena of post-ovoid syndrome in the form of asthenic syndrome: weakness, decreased appetite, weight loss.
Local application of heparin ointment as a trigger factor for the heparin-induced thrombocytopenia
Authors: Schastlivtsev I. V. , Lobastov K. V. , Alenichev A. V.
Published: November 2022

Heparin-induced thrombocytopenia (GIT) is a paradoxical reaction of platelets to heparin (their aggregation and destruction), potentially dangerous by the development of venous and arterial thrombosis, less often bleeding. There are serious problems of timely diagnosis of this complication. They are due to both insufficient awareness of specialists and the presence of a negative psychological attitude. The article presents a clinical case of treatment of a 57-year-old patient who was prescribed local application of heparin ointment for catheter thrombosis of the superficial veins of the left upper limb. After 8 days, the patient developed a clinical and instrumental picture of occlusive thrombosis of the right brachial vein. The patient was prescribed enoxaparin 0.6 x 2 times a day subcutaneously. After 4 days since the appointment of enoxaparin, a sharp deterioration in the patient’s condition: lower paraplegia with impaired pelvic organ function developed. There was a decrease in platelet levels by more than 2 times to 49x109/l. The probability of developing GIT on the «4T» scale is 8 points (high probability of GIT). Despite the treatment, the patient’s condition progressively worsened with the development of thrombosis of the infrarenal aorta, both common iliac arteries, massive trunk thromboembolism, segmental and subsegmental branches of the left pulmonary artery, intracerebral hemorrhage with a breakthrough into the ventricular system. Conclusion: heparin-induced thrombocytopenia, a rare but extremely dangerous complication observed in patients receiving heparin. The key to preventing the catastrophic consequences of GIT is awareness, alertness of clinicians and the use of modern algorithms for the diagnosis and treatment of GIT.
MEDIATION AS A WAY TO RESOLVE FAMILY DISPUTES AND DISAGREEMENTS
Authors:   Institute of State and Law of the Russian Academy of Sciences, Moscow, Russian Federation, LETOVA  NATALIA
Published: November 2022

Purpose of the study. In this article, the author examines the social and legal purpose of the institution of mediation in the field of family relations, its impact on the settlement of conflicts, disputes, disagreements in the family that arise between family members, identifies the features of mediation agreements, identifies their advantages as a way to protect the rights of participants in a dispute and a variety of pre-trial the procedure for resolving disagreements between the parties, the trends in the development of the institution of mediation in our country are determined. The author comes to the conclusion about the preventive value of mediation agreements, the wide distribution of which in practice will eliminate the need for the parties to apply to the court for the protection of their rights, except in cases where it is not possible to protect the right of a family member in any other way.
LINGUISTIC AND LEGAL ANALYSIS OF THE TERM «DWELLING» IN THE LEGAL TEXT SPACE
Authors:   Kuban State University, Krasnodar, Russian Federation, TSYPINA ALLA
Published: November 2022

The purpose of the study. The article examines the problems of interpretation of the concept of housing in various branches of law, examines the relationship between the term and the concept in the textual legal space. The purpose of the work is to analyze the existing definitions of the concept of housing in the diversified legislation for possible further unification of this concept in the legal text space, analysis of the use of the lexical unit housing as a term and concept. Conclusions. As a result of the conducted research, the author comes to the conclusion that it is possible to develop a single unified concept of housing for close or related areas of law (for criminal and criminal procedure law, for operational investigative activities), guided by the optimization method specified in the article. From the point of view of linguistic correctness, the author recommends the use of the phrase «dwelling» in the sectoral legal aspects, and in the general legal context, the phrase concept.
ANALYSIS OF THE LEGAL INSTRUMENTS OF THE EUROPEAN UNION REGULATING ITS LEGAL STATUS IN THE WORLD CUSTOMS ORGANIZATION
Authors:   Research Institute of the Russian Customs Academy, Lyubertsy, Russian Federation, MOZER  SERGEI
Published: November 2022

A task. To systematize and analyze the EU legal instruments and tools developed by authorized European institutions in connection with the consideration of an application for membership in the World Customs Organization. Conclusions. The research article is devoted to the issue of the EU legal status in the WCO and the use of the EU precedent for the implementation of the Strategic Directions for the Development of Eurasian Economic Integration until 2025 (Strategic Directions) in terms of joint actions with Member States aimed at obtaining the Union's membership status in the WCO. The subject of the study is the EU approaches to the legal status in the WCO; explanatory memorandum of the European Commission on WCO membership; Council decision on the accession of the European Communities to the World Customs Organization and the exercise of rights and obligations akin to membership ad interim; Declaration of competence by the European Communities in matters covered by the Convention establishing a Customs Co-operation Council. The analysis of the EU legal instruments in relation to the WCO membership can be used to develop legal tools for the Eurasian Economic Union (EEU) to obtain the status of the WCO member in the course of implementing the Strategic Directions. Social Consequences. Conducting a study of the legal status of customs and economic unions in the WCO is associated with the implementation of paragraph 11.7.5. of Strategic Directions in terms of cooperation with this international organization. Practical value. The results of the study are of interest to the customs cooperation block of the Eurasian Economic Commission (EEC), and can be used by specialists from customs and other executive authorities in the EEU member states, EEC experts to organize and implement mutually beneficial customs cooperation between the EEC and the WCO. The article is recommended to researchers, teachers, students, graduate students and other categories of students in the Russian Customs Academy, in other universities and the WCO regional training centers in the specialties «Customs» and «Jurisprudence». Originality/value. The research material is based on an analysis of the practical aspects of the activities of the EU, the WCO and is the result of a comprehensive study of the issue of the legal and organizational basis for obtaining the WCO member status by economic and customs unions.
THEORETICAL ASPECTS OF APPLICATION OF ISLAMIC ECONOMIC CONCEPT IN MODERN CONDITIONS OF DEVELOPMENT OF RUSSIAN ECONOMY
Authors:   Academy of Management of Internal Affairs of Russia, Moscow, Russian Federation, BULGAKOVA MARINA
Published: November 2022

In the current conditions of the functioning of the world community, the aggravation of political confrontation, the ongoing sanctions pressure and the increase in military threats, it becomes necessary to find new vectors for the development of the Russian economy, based not only on import substitution and their own developments, as well as the positive experience of states that have been subjected to economic isolation from European states and the United States of America. In times of crisis, thanks to the human potential of Russia, innovative and breakthrough prospects were formed. The article is devoted to the theoretical aspects of the application of the Islamic economic concept, which is due to the widespread spread of Islam in Russia, the development of Hahal initiatives and Halal enterprises. The author studied the main aspects of Islamic economic theory, the range and prospects for its distribution in the Eurasian economic space, which served as the basis for the formation of promising trends and problematic issues of the application of Islamic economic theory at the current stage of Russia's development.
OPPORTUNITIES AND LIMITATIONS OF THE ACTIVITIES OF THE AUTHORIZED BODY TO INITIATE THE BANKRUPTCY OF A TAX DEBTOR
Authors: KHORUZHIY  VALERY , BOGDANOVA  NATALIA
Published: November 2022

Purpose of the study. The article examines current trends and current problems of the activities of the Federal Tax Service of Russia in the status of an authorized body to initiate the bankruptcy of a tax debtor in order to recover tax debts. From the standpoint of the synthesis of theoretical approaches and arbitration practice, the prerequisites for initiating a bankruptcy case for a tax debtor have been studied; the research discloses groups of tax debtors to which it is advisable to apply measures to prevent bankruptcy and groups to which such measures are not applicable; the place of the mechanism of bankruptcy of the taxpayer in the general system of settlement of tax debts is shown; the main problems in initiating the bankruptcy of a tax debtor and measures taken by the authorized body to protect the interests of the Russian Federation as a creditor are identified on examples of the analysis of judicial practice in the processes of bankruptcy of legal entities. Conclusions. In the context of the development of forms and methods of pre-trial settlement of tax debts, the bankruptcy mechanism becomes an extreme measure of its settlement, which, in some cases, is an incentive for the tax debtor to move to the settlement agreement process before the introduction of the first bankruptcy procedure, and, in other cases, becomes an impulse for the authorized body to the formation and implementation of a well-thought-out constructive strategy and tactics for the effective implementation of the procedures used in bankruptcy cases of the debtor. The results of this study create the basis for the subsequent improvement of the organizational and economic mechanism of the activities of the authorized body for the protection of state interests in the bankruptcy of debtors.
MODERN CONSTITUTIONAL AND LEGAL THOUGHT OF THE REPUBLICS OF PARAGUAY AND PERU (WITH AN EMPHASIS ON PRIVATE LAW AND OTHER ISSUES)
Authors:   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, BELIKOVA  KSENIA
Published: November 2022

The subject of the research and the purpose of this article is to study the modern constitutional and legal thought of two countries of the American continent-the Republic of Paraguay and Republic of Peru, expressed in its current Constitution of 1992 (Paraguay) in the 2011 edition and of 1993 (Peru) in the 2021 edition. The research methodology is based on materialistic dialectics and consists of data collection by analyzing the named legal acts, doctrine and descriptive approach to legal norms in the field under study, as well as reflexive practice. The method of system analysis and comprehension of the ideas presented in the mentioned editions of Constitutions is used along with such operations as induction and deduction; methods of formal and dialectical logic help to understand the relationship between the results of constitutional reforms and the presence (absence) of the need for them; a materialistic view of the processes and phenomena of the external world as a whole allows us to believe that all the patterns fixed in the studied Constitutions that receive (or do not receive) further development are subjectively and objectively conditioned and set. The scientific novelty of the work is determined by the goal set and the conclusions drawn. Among the conclusions reached by the author are the following. For example, general principles and transparent general rules have been identified that create a favorable legal climate for both residents of both Republics and investors; it has been established that the highest goal of the Republics is the protection of human beings and their personalities, recognition and respect for their rights and freedoms and human dignity. Against this background, the Constitution of 1992 (Paraguay) attempts to limit the powers of the President strengthening the powers of Congress, whereas the Constitution of 1993 (Peru), on the contrary, provides for the possibility of Congress delegating legislative powers to the President, thereby expanding the already wide range of powers granted to him, etc
Contributions of SGK3 to transporter-related diseases
Authors: Liao Qian-Qian , Dong Qing-Qing , Zhang Hui , Shu Hua-Pan , Tu Yu-Chi , Yao Li-Jun
Published: December 2022

Serum- and glucocorticoid-induced kinase 3 (SGK3), which is ubiquitously expressed in mammals, is regulated by estrogens and androgens. SGK3 is activated by insulin and growth factors through signaling pathways involving phosphatidylinositol-3-kinase (PI3K), 3-phosphoinositide-dependent kinase-1 (PDK-1), and mammalian target of rapamycin complex 2 (mTORC2). Activated SGK3 can activate ion channels (TRPV5/6, SOC, Kv1.3, Kv1.5, Kv7.1, BKCa, Kir2.1, Kir2.2, ENaC, Nav1.5, ClC-2, and ClC Ka), carriers and receptors (Npt2a, Npt2b, NHE3, GluR1, GluR6, SN1, EAAT1, EAAT2, EAAT4, EAAT5, SGLT1, SLC1A5, SLC6A19, SLC6A8, and NaDC1), and Na+/K+-ATPase, promoting the transportation of calcium, phosphorus, sodium, glucose, and neutral amino acids in the kidney and intestine, the absorption of potassium and neutral amino acids in the renal tubules, the transportation of glutamate and glutamine in the nervous system, and the transportation of creatine. SGK3-sensitive transporters contribute to a variety of physiological and pathophysiological processes, such as maintaining calcium and phosphorus homeostasis, hydro-salinity balance and acid-base balance, cell proliferation, muscle action potential, cardiac and neural electrophysiological disturbances, bone density, intestinal nutrition absorption, immune function, and multiple substance metabolism. These processes are related to kidney stones, hypophosphorous rickets, multiple syndromes, arrhythmia, hypertension, heart failure, epilepsy, Alzheimer’s disease, amyotrophic lateral sclerosis, glaucoma, ataxia idiopathic deafness, and other diseases.
Non-alcoholic fatty liver disease in type 1 diabetes: Prevalence and pathophysiology
Authors: Memaj Plator , Jornayvaz François R.
Published: December 2022

Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the general population with a global prevalence of 25%. It is often associated with metabolic syndrome and type 2 diabetes, as insulin resistance and hyperinsulinemia are known to be favoring factors. Recent studies have described growing incidence of NAFLD in type 1 diabetes (T1D) as well. Although increasing prevalence of metabolic syndrome in these patients seems to explain part of this increase in NAFLD, other underlying mechanisms may participate in the emergence of NAFLD. Notably, some genetic factors are more associated with fatty liver disease, but their prevalence in T1D has not been evaluated. Moreover, oxidative stress, poor glucose control and long-lasting hyperglycemia, as well as exogenous insulin administration play an important role in intrahepatic fat homeostasis. The main differential diagnosis of NAFLD in T1D is glycogenic hepatopathy, which needs to be considered mostly in T1D patients with poor glycemic control. This article aims to review the prevalence and pathophysiology of NAFLD in T1D and open perspectives for clinicians taking care of T1D patients with potential hepatopathy.
Assessment of a diverse panel of transmitted/founder HIV-1 infectious molecular clones in a luciferase based CD8 T-cell mediated viral inhibition assay
Authors: Fernandez Natalia , Hayes Peter , Makinde Julia , Hare Jonathan , King Deborah , Xu Rui , Rehawi Ola , Mezzell Allison T. , Kato Laban , Mugaba Susan , Serwanga Jennifer , Chemweno James , Nduati Eunice , Price Matt A. , Osier Faith , Ochsenbauer Christina , Yue Ling , Hunter Eric , Gilmour Jill ,   The IAVI protocol C investigators
Published: December 2022

Introduction

Immunological protection against human immunodeficiency virus-1 (HIV-1) infection is likely to require both humoral and cell-mediated immune responses, the latter involving cytotoxic CD8 T-cells. Characterisation of CD8 T-cell mediated direct anti-viral activity would provide understanding of potential correlates of immune protection and identification of critical epitopes associated with HIV-1 control.

Methods

The present report describes a functional viral inhibition assay (VIA) to assess CD8 T-cell-mediated inhibition of replication of a large and diverse panel of 45 HIV-1 infectious molecular clones (IMC) engineered with a Renilla reniformis luciferase reporter gene (LucR), referred to as IMC-LucR. HIV-1 IMC replication in CD4 T-cells and CD8 T-cell mediated inhibition was characterised in both ART naive subjects living with HIV-1 covering a broad human leukocyte antigen (HLA) distribution and compared with uninfected subjects.

Results & discussion

CD4 and CD8 T-cell lines were established from subjects vaccinated with a candidate HIV-1 vaccine and provided standard positive controls for both assay quality control and facilitating training and technology transfer. The assay was successfully established across 3 clinical research centres in Kenya, Uganda and the United Kingdom and shown to be reproducible. This IMC-LucR VIA enables characterisation of functional CD8 T-cell responses providing a tool for rational T-cell immunogen design of HIV-1 vaccine candidates and evaluation of vaccine-induced T-cell responses in HIV-1 clinical trials.
The network of nitrifying and pathogenic prokaryotic interactions in a recirculating aquaculture system of a sole (Solea senegalensis) hatchery
Authors: Bastos Almeida Diana , Semedo Miguel , Magalhães Catarina , Blanquet Isidro , Mucha Ana Paula
Published: December 2022

Prokaryotic interactions in recirculating aquaculture systems (RAS) environmental communities may play a crucial role in driving their functional potential. However, these interactions are often neglected. The aim of this work is to detect prokaryotic interactions in a Solea senegalensis RAS, through the definition of relevant taxa and cluster identification using co-variance and co-occurrence tools. Amplicon sequence variants (ASV) were obtained from the water, tank biofilm, and biofilters of two systems, pre-ongrowing and weaning, and the study focuses on two microbial target groups, the potentially pathogenic and the nitrifying prokaryotes. No significant negative correlations were found with any target ASVs, indicating a mostly cooperative environment. As expected, ammonia oxidizing bacteria (Nitrosomonas) and archaea (Candidatus Nitrosopumilus) were found to be positively interacting with the nitrite oxidizing bacteria Nitrospira. However, no interactions were found between them, and results hint at a niche differentiation based on ammonia competition. Nitrospira also showed subcommunities with no ammonia oxidizing archaea or ammonia oxidizing bacteria correlations, hinting at a separate functional role of complete ammonia oxidation to nitrate for some Nitrospira ASVs. Two taxa commonly associated with pathogenic outbreaks, Tenacibaculum and Vibrio, had a significant positive correlation in one of the systems. With no outbreaks reported, this association may prove relevant in disease preventions and to improve outbreak predictions. Future studies may further elucidate this interaction, as cumulative evidence is still needed to better understand this correlation.
One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage
Authors: Vione Beatrice , Ramacieri Giuseppe , Zavaroni Giacomo , Piano Angela , La Rocca Giorgia , Caracausi Maria , Vitale Lorenza , Piovesan Allison , Gori Caterina , Pirazzoli Gian Luca , Strippoli Pierluigi , Cocchi Guido , Corvaglia Luigi , Locatelli Chiara , Pelleri Maria Chiara , Antonaros Francesca
Published: December 2022

Introduction

Down syndrome (DS) is the most common chromosomal disorder and it is caused by trisomy of chromosome 21 (Hsa21). Subjects with DS show a large heterogeneity of phenotypes and the most constant clinical features present are typical facies and intellectual disability (ID). Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.

Methods

We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. We investigated: tetrahydrofolate (THF; DS n = 108, control n = 41), 5-methyltetrahydrofolate (5-methyl-THF; DS n = 140, control n = 34), 5-formyltetrahydrofolate (5-formyl-THF; DS n = 80, control n = 21), S-adenosyl-homocysteine (SAH; DS n = 94, control n = 20) and S-adenosyl-methionine (SAM; DS n = 24, control n = 15).

Results

Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. Moreover, SAM and SAH show a ratio DS/control of 1.82:1 and 3.6:1, respectively.

Discussion

The relevance of these results for the biology of intelligence and its impairment in trisomy 21 is discussed, leading to the final proposal of 5-methyl-THF as the best candidate for a clinical trial aimed at restoring the dysregulation of one-carbon cycle in trisomy 21, possibly improving cognitive skills of subjects with DS.
Effect of epiphytic microflora after aerobic enrichment and reconstitution on fermentation quality and microbial community of corn stalk silage and Pennisetum sinese silage
Authors: Xie Yixiao , Du Ermei , Yao Yudie , Wang Wanqing , Huang Xiaokang , Sun Hong , Zheng Yulong , Cheng Qiming , Wang Chunmei , Chen Chao , Li Ping
Published: December 2022

Introduction

The objective of this study was to evaluate the effects of enrichment and reconstitution of the forage epiphytic microflora on the fermentation quality, chemical composition, and bacterial community composition of corn stalk and Pennisetum sinese silages.

Methods

The forage juice of fresh corn stalk and P. sinese were collected, diluted by gradient (10–1 to 10–5), and aerobically incubated to enrich and reconstitute the epiphytic microflora. Fresh corn stalk and P. sinese were ensiled for 3, 15, and 45 days after inoculation with either the original (D0) pre-incubated juices, or 10–1 (D1), 10–3 (D3), or 10–5 (D5) diluted and pre-incubated juices.

Results

The lowest pH was found in the D3 treatment of the corn stalk silage. In P. sinese silage, the hemicellulose content of D3 and D5 treatments was 9.50 and 11.81% lower than that of D0 treatment (P < 0.05). In corn stalk silage, the neutral detergent fiber content was significantly lower in the D3 treatment than in the other treatments (P < 0.05). Both corn stalk and P. sinese silages exhibited a high abundance of Enterobacter during ensiling, resulting in high levels of acetic acid.

Conclusion

Although the dilution and enrichment of the epiphytic microflora did not lead to full lactic acid fermentation, these pre-treatments were found to alter the microbial metabolites and chemical composition of the silage. These results provide a new perspective on the production of pre-fermented silage inoculant.