The Effect of Cerebrolysin on the Predictive Value of Baseline Prognostic Risk Score in Moderate and Severe Traumatic Brain Injury
Authors: Birle Codruta ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania, Slavoaca Dana ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania, Muresanu Ioana ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania, Chira Diana ,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania, Vacaras Vitalie ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   Neurology Clinic, Cluj Emergency County Hospital, Cluj-Napoca, Romania, Dora Stan Adina ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   Neurology Clinic, Cluj Emergency County Hospital, Cluj-Napoca, Romania, Dina Constantin ,   Department of Radiology, “Ovidius” University, Faculty of Medicine, Constanta, Romania, Strilciuc Stefan ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania
Published: November 2022

Cognitive dysfunction is a significant complaint among patients after moderate to severe traumatic brain injury (TBI), with devastating consequences on functional recovery and quality of life. Prognostic models allow a better assessment and management of neurotrauma patients.

The aim of the study was to demonstrate the predictive value of the Baseline Prognostic Risk Score (BPRS) in moderate to severe TBI, in a sample of patients treated with neurotrophic factors.

Eighty patients with moderate-severe TBI from the CAPTAIN II study were included in secondary data analysis. Patients received active treatment with Cerebrolysin, 50 mL per day for ten days, followed by two treatment cycles with 10 mL per day for ten days. BPRS was determined on admission; the age was recorded, and patients were evaluated using the following neurocognitive tests: Mini-Mental State Essay (MMSE), Wechsler Adult Intelligence Scale-Third Edition Processing Speed Index (WAIS-III PSI) and Stroop Colour Word Test-Victoria Version at 10, 30 and 90 days. Hierarchical regression analysis was performed to investigate the unique predictive value of BPRS on cognitive evolution, independent of age. BPRS independently predicted scores on the WAIS-III PSI DSCales and the Word subscale of the Stroop Colour Word Test at 90 days. Age was a significant predictor for all the investigated scales at 10, 30, and 90 days.

This study demonstrates the predictive value of a validated prognostic model (BPRS) for medium-term neurocognitive outcomes in a sample of moderate-severe traumatic brain injury treated with neurotrophic factors.