bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Performance Assessment of Adsorbents for CO2 Capture via Physisorption in a Diesel Engine Exhaust
Authors: Ravi Maniarasu
Published: February 2023

The atmospheric carbon dioxide (CO2) concentration has been consistently increasing each year throughout the world. Internal combustion (IC) engines are significant contributors to CO2 emissions. This study explores the possibility of employing effective biomass‐based adsorbents to mitigate CO2 from a diesel engine exhaust. As a first step, two distinct agro‐wastes, namely, i) corn cob and ii) sugarcane bagasse, are used to prepare inexpensive and efficient activated carbons. The two main steps in the activated carbon preparation are a) carbonization and b) activation. The derived activated carbons are subjected to discrete analytical techniques to examine their structural and textural characteristics, surface functional groups, and physical, chemical, and adsorptive properties. As a second step, the exhaust treatment chamber unit is filled with the adsorbents one by one and is connected to the exhaust of the constant pressure heat addition engine. A single‐cylinder, four‐stroke, naturally‐aspirated, air‐cooled, direct injection (DI) compression ignition (CI) engine is used in the experimental investigations. The essential findings show that ≈68 and 60% of CO2 emissions are adsorbed in the test engine by utilizing corn cob and sugarcane bagasse adsorbents, respectively. The results show that during the D100 and JME20 operations, the prospective adsorbents can curb more than 40% of overall CO2 emissions.
Genomic and proteomic characterization of Philadelphia‐like B‐lineage acute lymphoblastic leukemia: A report of Indian patients
Authors: Gupta Dikshat Gopal , Varma Neelam , Kumar Ashish , Naseem Shano , Sachdeva Man Updesh Singh , Sreedharanunni Sreejesh , Binota Jogeshwar , Bose Parveen , Khadwal Alka , Malhotra Pankaj , Varma Subhash
Published: February 2023

Background

The gold standard for the identification of Philadelphia (Ph)‐like acute lymphoblastic leukemia (ALL) patients is gene expression profiling. Because of its diverse nature, its identification is extremely difficult and expensive. On the genomic and proteomic landscape of Ph‐like ALL patients, there is a paucity of published literature from developing countries.

Methods

The authors used digital barcoded nCounter NanoString gene expression profiling for its detection, followed by molecular and proteomic characterization using fluorescence in situ hybridization and liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Results

The authors found 32.05% Ph‐like ALL patients and their median age at presentation was considerably higher than Ph‐negative ALL cases (p = .0306). Furthermore, we identified 20% CRLF2 overexpressed cases having 8.33% CRLF2‐IGH translocation with concomitant R683S mutation and 8.33% CRLF2‐P2RY8 translocation. In 80% of CRLF2 downregulated cases, we identified 10% as having JAK2 rearrangement. Minimal residual disease‐positivity was more common in Ph‐like ALL cases (55.55% vs. 25% in Ph‐negative ALL cases). Immunoglobulin J chain (Jchain), small nuclear ribonucleoprotein SmD1 (SNRPD1), immunoglobulin κ constant (IGKC), NADH dehydrogenase (ubiquinone) 1 α subcomplex subunit 2 (NDUFA2), histone H2AX (H2AFX), charged multivesicular body protein 4b (CHMP4B), and carbonyl reductase (NADPH) (CBR1) proteins were identified to be substantially expressed in Ph‐like ALL patients, using LC–MS/MS. Gene enrichment analysis indicated that involvement of spliceosomal mediated messenger RNA splicing pathway and four microRNAs was statistically significant in Ph‐like ALL patients.

Conclusions

For the first time, we have described incidence, molecular, and proteomic characterization of Ph‐like ALL, in developing nations.

Plain language summary

In developing countries, detecting Philadelphia (Ph)‐like B‐lineage acute lymphoblastic leukemia is complicated and challenging due to its diverse genetic landscape.

There is no well‐defined and cost‐effective methodology for its detection.

The incidence of this high‐risk subtype is very high in adult cases, and there is an urgent need for its accurate detection.

We have developed an online PHi‐RACE classifier for its rapid detection, followed by delineating the genomic and proteomic landscape of Ph‐like acute lymphoblastic leukemias for the first time in Indian patients.
Molecular disparity of HLA‐DPB1 is associated with the development of subsequent solid cancer after allogeneic hematopoietic stem cell transplantation
Authors: Zou Jun , Kongtim Piyanuch , Oran Betül , Srour Samer A. , Greenbaum Uri , Carmazzi Yudith , Rondon Gabriela , Ciurea Stefan O. , Ma Qing , Shpall Elizabeth J. , Champlin Richard E. , Cao Kai
Published: February 2023

Background

An increased incidence of subsequent solid cancers (SSCs) has been reported in long‐term survivors of allogeneic hematopoietic stem cell transplantation (allo‐HSCT), and SSC is associated with inferior mortality and morbidity. Previous studies showed that the incidence of SSC is significantly higher in those who underwent allo‐HSCT from HLA‐mismatched donors, suggesting that persistent alloimmunity may predispose patients to SSCs. It was recently reported that, in a cohort of patients who received allo‐HSCT from an unrelated donor matched at HLA‐A, ‐B, ‐C, ‐DRB1/3/4/5, and ‐DQB1 loci, HLA‐DPB1 alloimmunity determined by high mismatched eplets (MEs) and Predicted Indirectly Recognizable HLA Epitopes (PIRCHE) score (PS), was associated with relapse protection and increased risk of acute graft‐versus‐host disease (GVHD).

Methods

In the present study, the impact of HLA‐DPB1 alloimmunity assessed by molecular mismatch algorithms on the development of SSCs in a cohort of 1514 patients who underwent allo‐HSCT for hematologic malignancies was further investigated. ME load at the HLA‐DPB1 locus was measured using the HLAMatchmaker module incorporated in HLA Fusion software, and the PS for mismatched HLA‐DPB1 was calculated using the HSCT module from the PIRCHE online matching service.

Results

In multivariable analysis after adjusting for baseline risk factors, higher ME, PS‐I, and PS‐II in the GVH direction, but not in the HVG direction, were associated with an increased risk of SSCs (ME: subdistribution hazard ratio [SHR] 1.58, p = .01; PS‐I: SHR 1.59, p = .009; PS‐II: SHR 1.71, p = .003). In contrast, nonpermissive HLA‐DPB1 mismatches defined by the conventional T‐cell epitope algorithm were not predictive of the risk of SSCs. Moreover, posttransplant cyclophosphamide‐based GVHD prophylaxis was associated with a reduced risk of subsequent solid cancer (SHR 0.34, p = .021).

Conclusions

These results indicate for the first time that increased GVH alloreactivity could contribute to the development of SSCs in allo‐HSCT survivors.
Pediatric magnetoencephalography
Authors: Nordli Douglas R. , Galan Fernando N.
Published: February 2023

Magnetoencephalography (MEG) is a technology used in pediatric and adult epilepsy that records magnetic fields produced from electric currents in the brain. MEG can locate epileptogenic zone(s), lateralize language functions, localize sensorimotor cortex, and identify visually evoked fields. It is a powerful technology with key advantages in pediatrics. The majority of its limitations are resource driven. With advancing technology, MEG will become a more prominent and valuable tool used in pediatric epilepsy and epilepsy surgery in the future. We review MEG and provide illustrative cases to showcase its usage.
Digital transformation and environmental performance: Evidence from Chinese resource‐based enterprises
Authors: Xu Qiong , Li Xin , Guo Fei
Published: February 2023

Digitalization is of great significance for resource‐based enterprises to break through the dual constraints of resource and environment. Based on the data of China's A‐share resource‐based listed enterprises, this study empirically examines the direct effect and transmission mechanism of digital transformation on the enterprises' environmental performance. The study finds that digital transformation significantly enhances the environmental performance of enterprises by stimulating green technology innovation, accelerating human capital accumulation, increasing environmental information disclosure, and strengthening environmental governance. The environmental performance of state‐owned, large‐size and high‐tech resource‐based enterprises is more prominently affected by digital transformation. In the eastern region and areas with higher environmental regulation, the impact of digital transformation on the environmental performance of resource‐based enterprises is more significant. This study provides targeted suggestions for resource‐based enterprises to make full use of the digital dividends and achieve high‐quality development.
Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single‐cell RNA sequencing
Authors: He Shiwei , Wang Junfeng , Huang Yanlei , Kong Fanyang , Yang Ran , Zhan Yong , Li Zifeng , Ye Chunjing , Meng Lingdu , Ren Yankang , Zhou Ying , Chen Gong , Shen Zhen , Sun Song , Zheng Shan , Dong Rui
Published: February 2023

Background

Hirschsprung's disease (HSCR) is a relatively common congenital disability. Accumulating extracellular matrix (ECM) prompts intestinal fibrosis remodelling in the aganglionic segments of HSCR. The contributions of various cellular subsets in the fibrogenesis of HSCR segments are poorly understood.

Methods

Single‐cell transcriptomics from 8 aganglionic segments and 5 normal segments of 7 HSCR subjects and 26 healthy segments of seven healthy donors were analysed. Fibrotic phenotype and alterations were explored using differential expression analysis and single‐cell trajectory analysis. Fibrosis‐related transcription factors were inferred through single‐cell regulatory network inference. Bulk transcriptomic data, proteomic data, immunohistochemistry (IHC) and real‐time polymerase chain reaction were used to validate the alterations in the HSCR intestine.

Results

Various collagen, fibronectin and laminin protein‐coding genes expression were up‐regulated in the stromal and glial cells of the HSCR intestine. The number of fibroblasts and myofibroblasts in the aganglionic segments increased, and more myofibroblasts were activated at an earlier stage in HSCR segments, which infers that there is an intestinal fibrosis phenotype in HSCR segments. The fibrotic regulators POSTN, ANXA1 and HSP70 were highly expressed in the ECM‐related cellular subsets in the transitional segments and aganglionic segments. The transcription factor regulatory network revealed that fibrosis‐related and megacolon‐related NR2F1 in the fibroblasts and glial subsets was up‐regulated in the aganglionic segment.

Conclusions

This work identifies intestinal fibrosis and related regulators in aganglionic segments of HSCR; hence, anti‐fibrotic therapy may be considered to prevent HSCR‐associated enterocolitis (HAEC), relieve intestinal stricture and improve cell therapy.
Influence of natal habitat preference on habitat selection during extra‐home range movements in a large ungulate
Authors: Hooven Nathan D. , Springer Matthew T. , Nielsen Clayton K. , Schauber Eric M.
Published: February 2023

Natal habitat preference induction (NHPI) occurs when animals exhibit a preference for new habitat that is similar to that which they experienced in their natal environment, potentially leading to post‐dispersal success. While the study of NHPI is typically focused on post‐settlement home ranges, we investigated how this behavior may manifest during extra‐home range movements (EHRMs), both to identify exploratory prospecting behavior and assess how natal habitat cues may influence path selection before settlement. We analyzed GPS collar relocation data collected during 79 EHRMs made by 34 juvenile and subadult white‐tailed deer (Odocoileus virginianus) across an agricultural landscape with highly fragmented forests in Illinois, USA. We developed a workflow to measure multidimensional natal habitat dissimilarity for each EHRM relocation and fit step‐selection functions to evaluate whether natal habitat similarity explained habitat selection along movement paths. Across seasons, selection for natal habitat similarity was generally weak during excursive movements, but strong during dispersals, indicating that NHPI is manifested in dispersal habitat selection in this study system and bolstering the hypothesis that excursive movements differ functionally from dispersal. Our approach for extending the NHPI hypothesis to behavior during EHRMs can be applied to a variety of taxa and can expand our understanding of how individual behavioral variation and early life experience may shape connectivity and resistance across landscapes.
Spatial variation of pollen receipt and effects of heterospecific pollen on seed set in Salvia przewalskii
Authors: Fang Qiang , Zhang Tao , Montgomery Benjamin R.
Published: February 2023

Generalized pollinators visit multiple co‐flowering plant species and may transfer heterospecific pollen grains. Recent studies have indicated that the effect of heterospecific pollen (HP) on reproduction success is variable and depends on the identity of donor and recipient species. However, few studies have documented variation in HP receipt and evaluated the reproductive effects of HP receipt across geographic locations under natural conditions. We investigated the spatial variation of pollen deposition across eight sites and how the pollen receipt related to the seed set of Salvia przewalskii, a subalpine perennial herb in Hengduan Mountain in southwest China. We found that stigmatic pollen loads substantially varied among sites for several metrics, including quantities of conspecific and heterospecific pollen, the proportion of HP, and species composition of HP donors. Five different plant families were the most common HP source at one or two sites, and the proportion of HP ranged from 3.4% to 51.3% across sites. The association of conspecific pollen with seed set was positive and variable among sites, whereas the association of HP receipt and seed set was negative and not significantly different among sites. Our results demonstrate variation in the quantity and fitness effect of pollen receipt across sites, which is a precondition for evolution of local adaptation. Further study of variation in patterns and effects of HP receipt for the same recipient species across natural communities would allow better understanding of the ecological and evolutionary consequences of HP receipt.
Modeling and coordinated control for active power regulation of pumped storage‐battery integrated system under small‐disturbances
Authors: Wang Zhecheng , Yang Weijia , Liao Yiwen , Li Yulan
Published: February 2023

Multienergy complementation is an important means to improve the capacity of renewable energy consumption and the key to achieving the goal of “net zero” globally. The hydro–wind–photovoltaic‐storage hybrid system is an important technical approach, and in this system, pumped storage and battery energy storage are both key components for regulation. To study the problem of coordinated control of the two storage systems, a model of a pumped storage‐battery integrated system (PSBIS) for simulating small disturbances of pumped storage units and the battery charge and discharge characteristics was established by MATLAB/Simulink in this study firstly. Then, two control strategies (“priority regulation of pumped storage” and “priority regulation of battery storage”) are studied, and simulation calculations under ideal input and measured wind power disturbances are carried out to compare two control strategies by using the integrated system model under grid‐connected conditions. The simulation results revealed that the “priority regulation of pumped storage” control strategy has a better performance on active power balance, compared with the “priority regulation of battery storage” control strategy. This work could provide technical support for coordinated control of the practical PSBIS in the future.
Comparative experimental study on macroscopic spray characteristics of various oxygenated diesel fuels
Authors: Bao Jianhui , Wang Haohao , Wang Ruofei , Wang Qingxin , Di Liming , Shi Cheng
Published: February 2023

Under high ambient pressure (5 MPa) and different injection pressures (90, 120, and 150 MPa), a high‐speed imaging technique was carried out to comparatively investigate the macroscopic spray characteristics of diesel with three different types of blended fuel in a constant volume chamber. The oxygenated fuels were n‐butanol (B), pine oil (P), and 2,5‐dimethylfuran (DMF). All their blending ratio with diesel were 20%. Results showed that less viscosity could be improved the spray characteristics of the fuel in the range of experimental conditions. Then, the tested fuels had a longer penetration and a greater spray area with increasing the injection pressure from 90 to 150 MPa. On the other hand, the percentage increases in the mean spray cone angle of D100, B20, P20, and DMF20 were 3%, 4.4%, 2.4%, and 2.9%, respectively. At the same experimental condition, the spray penetrations of DMF20 and P20 were larger than that of D100, but the spray penetration of B20 was basically similar to D100. Besides, the performance of the spray cone angle and spray area were D100 < B20 < P20 < DMF20. In addition, the comprehensive influence was that blending oxygenated fuels would be a benefit for developing fuel atomization and the air–fuel mixture of conventional diesel fuel.
Theoretical analysis of drilling cuttings considering stress zoning of surrounding rock and its application in stress detection
Authors: Geng Yanfeng , Tan Jian , Yin Yanchun , Tan Yunliang
Published: February 2023

Drilling cuttings method is a commonly used method to detect the risk of rockburst, which has been widely recognized and applied in coal mines. However, in the current theoretical research on the relationship between drilling cuttings method and coal stress, it is generally considered that the mechanical parameters of coal at different positions of roadway are unchanged, and the influence of surrounding rock plastic zone and elastic zone is not considered. Therefore, according to the secondary distribution characteristics of roadway side stress, the theoretical calculation formula of drilling cuttings in the plastic zone and elastic zone of the roadway side is established in this paper. The example shows that the distribution of cuttings on the roadway side is obviously consistent with the abutment pressure. The cuttings in the plastic zone and the elastic zone are in linear and power function with the coal stress, respectively, and the cuttings in the plastic zone are greater than those in the elastic zone. With the increase of the hole diameter, the slope of the relationship curve between the drill‐cutting weight and stress gradually increases, and the response of the drill‐cutting weight with a large hole diameter to the change of coal stress is more obvious. The numerical simulation results show that the error of the theoretical calculation formula of the drilling cuttings method is less than 9%, which can meet the engineering application needs of estimating the drill‐cutting weight in coal and the stress of coal. Using the theoretical formula, the stress field in the leading area of the working face is measured, and the leading influence range and the accurate position of the high stress concentration area are determined, which provides more comprehensive stress information for the early warning of impact danger and pressure relief.
Day‐ahead scheduling of a hybrid renewable energy system based on generation forecasting using a deep‐learning approach
Authors: Zamanidou Afroditi , Giannakopoulos Dionysios , Pappa Dimitra , Pitsilis Vasilis , Makropoulos Constantinos , Manolitsis Konstantinos
Published: February 2023

A significant amount of electricity in numerous regions worldwide is used for lighting roads, squares, and other public spaces. Renewable energy can contribute notably to electricity usage for public lighting. This paper focuses on the day‐ahead scheduling of a hybrid renewable energy system (HRES) exploiting solar–wind energy potential to meet the electrical energy needs of public lighting. The studied HRES provides electricity for a Wi‐Fi hotspot and a charging hotspot for the end users and has an energy storage system that ensures a reliable electricity supply without interruptions. The day‐ahead scheduling of the studied HRES is based on electricity generation forecasting by using a deep‐learning approach. Particularly, the long short‐term memory model is utilized, considering the fact that it is able to perceive long‐term dependencies among the time series. Moreover, the model's performance is investigated through the determination of diverse inputs: (a) historical data, (b) weather predictions, and (c) historical data with weather predictions. Multiple scenarios of energy consumption are assumed and applied to optimize the day‐ahead scheduling. A new recommendation method is proposed and applied for day‐ahead scheduling, utilizing the power forecasts to achieve optimum operation and energy savings. The results point out that the utilization of the proposed recommendation method controls loads when a shortage in power generation and battery capacity is forecasted for the day ahead, leading to significant energy savings and minimizing the power demand from the grid.
Validation of the name Quercus infectoria subsp. veneris var. pfaeffingeri (Fagaceae)
Authors: Panahi Parisa , Jamzad Ziba
Published: February 2023

Quercus infectoria Oliv. is a taxon with high morphological variation, and many infra‐specific have been described in this species, of which Q. infectoria Oliv. subsp. veneris (A.Kern) Meikle is present in the flora of Iran. In a taxonomic review of the Quercus L. taxa in Iran, based on morphological and micromorphological evidence, we recognized a new combination: Q. infectoria Oliv. subsp. boissieri (Reut.) O. Schwarz var. pfaeffingeri (Kotschy) Jamzad and Panahi, as a distinct taxon. Since the valid subspecific name for this taxon is subsp. veneris (A.Kern) Meikle var. pfaeffingeri, and the basionym of this name was not defined in the published manuscript. Here we correct the authorship and validate this name. Furthermore, we present the taxonomic history of Q. infectoria, descriptions of infraspecific taxa, a distribution map in Iran, ecological notes, and an identification key to infraspecific taxa.
Influence of extraction techniques on the efficiency of pomegranate (Punica granatum L.) peel extracts in oxidative stability of edible oils
Authors: Javani‐Seraji Samira , Bazargani‐Gilani Behnaz , Aghajani Narjes
Published: February 2023

In this study, the effects of pomegranate (Punica granatum L.) peel extract (PPE) on the oxidative stability of soybean oil and ghee were investigated under heat conditions. Three extraction methods (immersion, ultrasound, and combined immersion‐ultrasound) with eight solvents (hot water, cold water, absolute methanol, methanol 50%, absolute ethanol, ethanol 50%, absolute acetone, and acetone 50%) were used for the evaluation of the extracts. Ethanolic extract in maceration method significantly (p ≤ .05) showed the highest DPPH radical scavenging activity (95.018%), reducing power (3.981), and total phenolic content (520 mg GAE/g) compared to the other samples. Then, the effects of PPE in various concentrations (200, 400, 600, and 800 ppm) were compared to the synthetic antioxidant (Butylated hydroxytoluene 200 ppm) in the oxidative stability of soybean oil under 65°C and ghee under 55°C for 24 days with 6‐day intervals, respectively. During storage period, all treatments showed a significant decrease (p ≤ .05) in peroxide value, thiobarbituric acid reactive substances, conjugated dienes value, polar compounds value, and acid value compared to the control. Except for the PPE 200 treatment, the other treatments exhibited superior efficiency to the synthetic antioxidant in a dose‐dependent manner in accelerated stored edible oils. Based on the sensory analyses (flavor, odor, color, and overall acceptability), PPE significantly (p ≤ .05) preserved the sensory features compared to the control group during the entire storage time. PPE 800 ppm was the most efficient treatment in all analyses, followed by PPE 600, 400, and 200 ppm, respectively. Finally, it was concluded that PPE can be introduced as a unique alternative to synthetic antioxidants in edible oils under heating conditions.
The practice of manager as coach (MAC): Unequal power relations and their effect on feelings toward the organization
Authors: Ben‐Hador Batia
Published: February 2023

Manager as Coach (MAC) is a concept that relates to managers who actively coach their subordinates to improve their skills, competence, and performance. The MAC practice is a popular tool for managers in organizations; however, there is a debate about the benefits gained from coaching by MACs and a theoretical gap regarding the effectiveness of this process. The purpose of this study is to examine the different perceptions of managers who coach their subordinates and subordinates coached by their managers of the coaching process and to estimate the perceived success of this process. In‐depth interviews were conducted with 13 MACs and 9 coachees from various organizations in Israel. Qualitative content analysis was used to analyze and interpret the data. Basic analysis indicates that the perceptions of the MACs toward the coaching process were positive, whereas the coachees held mixed perceptions. The different perceptions point to the unequal power relations between the MACs and the coachees. In the interpretive analysis, it was found that the perceptions toward the MAC process affect coachee feelings toward the organization but not the coach's feelings. Relying on Leader‐Member Exchange (LMX) theory, the MAC process will be successful only if managers significantly reduce power distances. Therefore, organizations must offer their MACs significant coaching training to decrease the negative consequences of the MAC practice and to diminish the power distance between MAC and coachee.
Cut‐to‐the‐light technique is useful for complete obstruction of a Wallace ureteroileal anastomosis
Authors: Tsuboi Ichiro , Yokoyama Shuhei , Nakajima Hirochika , Yosioka Saori , Kobayashi Yusuke , Nagami Taichi , Ogawa Kohei , Wada Koichiro
Published: February 2023

Introduction

Obstruction of a ureteroileal anastomosis after urinary diversion is an unpleasant situation for patients and clinicians alike.

Case presentation

A 48‐year‐old man who underwent a radical cystectomy for muscle‐invasive bladder cancer and urinary diversion using the Wallace technique complained of right back pain. Computed tomography showed right hydronephrosis. Cystoscopy via the ileal conduit revealed complete obstruction of the ureteroileal anastomosis. We performed a bilateral approach (antegrade and retrograde) to use the cut‐to‐the‐light technique. A guidewire and 7Fr single J catheter could be inserted.

Conclusion

The cut‐to‐the‐light technique was useful for complete obstruction of the ureteroileal anastomosis, the length of which was <1 cm. Herein, we report on the cut‐to‐the‐light technique with a literature review.
Understanding and quantifying capacity loss in storage aging of Ah‐level Li metal pouch cells
Authors: Li Nan , You Jingyuan , Gao Yuliang , Qiao Fahong , Yang Yong , Jin Ting , Shen Chao , Huang Haitao , Xie Keyu
Published: February 2023

Promoting industry applications of high‐energy Li metal batteries (LMBs) is of vital importance for accelerating the electrification and decarbonization of our society. Unfortunately, the time‐dependent storage aging of Ah‐level Li metal pouch cells, a ubiquitous but crucial practical indicator, has not yet been revealed. Herein, we first report the storage behaviors and multilateral synergistic aging mechanism of Ah‐level NCM811||Li pouch cells during the 120‐day long‐term storage under various conditions. Contrary to the conventional belief of Li‐ion batteries with graphite intercalation anodes, the significant available capacity loss of 32.8% on average originates from the major electrolyte‐sensitive anode corrosion and partial superimposed cathode degradation, and the irreversible capacity loss of 13.3% is essentially attributed to the unrecoverable interface/structure deterioration of NCM with further hindrance of the aged Li. Moreover, principles of alleviating aging have been proposed. This work bridges academia and industry and enriches the fundamental epistemology of storage aging of LMBs, shedding light on realistic applications of high‐energy batteries.

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Modelling and prediction of groundwater level using wavelet transform and machine learning methods: A case study for the Sahneh Plain, Iran
Authors: Azizi Ehsan , Yosefvand Fariborz , Yaghoubi Behrouz , Izadbakhsh Mohammad Ali , Shabanlou Saeid
Published: February 2023

Due to the complexity of numerical models and the need for much information and data in these models, one of the important solutions is to use artificial intelligence models with a small number of required inputs and a simpler structure. In this study, using wavelet transform analysis (cross wavelet transform and wavelet transform coherence), a model was developed to extract the relationship between climatic data (i.e., temperature and precipitation) and groundwater level changes. The developed model provides the best relationship between the main effective climatic parameters and groundwater level changes in the Sahneh Plain. The results showed that the climatic variables of average temperature and precipitation are the parameters with the highest correlation coefficient with groundwater level changes in the main wells of the study area. The results of verification and validation of the numerical prediction model of groundwater level based on the climatic parameters indicate that the average error is between 3% and 10% in different areas of the plain, which indicates the high accuracy of the developed model. In areas with a lack of data and information required for numerical simulation, the proposed model used in this research can be used as a comprehensive model for assessing and predicting groundwater levels based on climatic parameters.
A spatial data integration and visualization approach for occupational health and safety risks management: Application to Algerian electricity and gas company
Authors: Haroun Hayat , Ghomari Abdessamed Réda
Published: February 2023

In the safety 4.0 era, occupational health and safety (OHS) related data has become one of the most valuable assets for organizations. Risk Management in the OHS field is a data‐driven process. However, geospatial data has not been fully considered and few works have used visualization for decision‐making purposes. Our research was conducted using a design science research methodology. It is a methodology for creating and evaluating IT artifacts to solve identified organizational problems. We used Wang's safety intelligence framework and the recommendations of the ISO 45001 model from extant literature to inform the Design. While creating our artifact, we chose to make an inventory of occupational risk prevention practices in Algeria. A qualitative study using interviews with experts in the field consolidated the requirements for such a system. The key findings from the analysis of collected data state that the development of safety data‐driven decision‐making requires top management support and involvement, which is in line with previous studies. A second concern is the availability of spatial data. The designed artifact is an approach called spatial data integration and visualization approach for occupational health and safety management systems (SDIVA‐OHSMS). SDIVA‐OHSMS provides a practical approach for organizations in charge of OHS services to implement OHS data‐driven decision‐making solutions highlighting spatial and semantic dimensions. The evaluation was performed through a representative case study within the Algerian electricity and gas company (Sonelgaz), employing expert opinion and software implementation. As a result, experts concluded that such systems could provide a more comprehensive and accurate view of occupational health issues and guide further prevention policies.
Evaluation of a transitions clinic to bridge emergency department and primary care
Authors: Zhang Amanda , Spiegel Thomas , Bundy Andrea , Sullivan Kate , Green Geneatra , Chia Stephanie , Krishnamurthy Rajlakshmi , Press Valerie G.
Published: February 2023

Background

Suboptimal transitions from the emergency department (ED) to ambulatory settings contribute to poor clinical outcomes and unnecessary nonurgent ED utilization. Care transition clinics (CTCs) are a potential solution by providing ED follow‐up and facilitating the bridge to longer‐term primary care.

Objective

The objective was to evaluate the implementation of an ED transitions clinic on 30‐day ED revisits and hospital readmissions.

Designs

Retrospective cross‐sectional study.

Settings and Participants

This study included adults 18 years and older discharged from the ED and reeferred to the CTC.

Main Outcome and Measures

Appointment attendance, follow‐up time, and frequencies of care type provided were computed to assess clinic utilization. Rates of 30‐day ED revisit and hospital admission were compared between completed and missed appointments using logistic regression.

Results

Between March 2021 and March 2022, 373 patients were referred to the CTC totaling 405 appointments. Half (53%) of appointments were completed with a median follow‐up time of 4 days (IQR = [2, 7]). The most common care types provided were wound care (44%) and clinical problem management (33%), with wound care appointments more likely to be completed compared with clinical appointments (OR = 1.7, CI = [1.1, 2.8], p = .03). Patients who completed their CTC appointment were 50% less likely to return to the ED in 30 days compared with those who did not complete their appointment (OR = 0.51, CI = [0.27, 0.98], p < .05). No effect was seen for CTC appointment completion on hospital readmission. Transition clinics are a viable method to provide timely access to follow‐up for patients discharged from the ED and may help reduce excess ED use for ambulatory care needs.
Assessment of sustainable development status of micro and small enterprises in Debre Berhan town, central Ethiopia
Authors: Alemayehu Arragaw , Bekele Demisash
Published: February 2023

This study investigates the sustainable development status of micro and small enterprises (MSEs) in Debre Berhan town in five major manufacturing sub‐sectors (textile and garment, agro‐processing, woodwork, food processing and beverage and metal works and engineering). The sustainable development status of the selected MSEs was evaluated using 16 indicators for the three pillars of sustainable development (economic, social and environmental). The results showed that economic sustainability was at a ‘low’ level, while social and environmental sustainability and the aggregate index were at ‘moderate’ levels. Therefore, integrated support is required to overcome the identified challenges MSEs face to achieve sustainable development.
Placental glycotype of the caviomorph rodent Lagostomus maximus and its evolution within Eutheria
Authors: Acuña Francisco , Carril Julieta , Portiansky Enrique L. , Flamini Mirta A. , Miglino María A. , Barbeito Claudio G.
Published: February 2023

The main evolutionary milestone in the oviparity–viviparity transition is placentation. The placenta is an organ with great morphological diversity among eutherians. The expression of different glycosidic residues (Gr) in the near‐term placenta constitutes its glycotype. In this study, the expression of different Gr was determined by lectin histochemistry in early, midterm, and near‐term placentas of the plains viscacha (Lagostomus maximus), a caviomorph rodent with the highest poliovulatory rate and embryonic resorption rate among eutherians. Besides, a matrix with the expression of each Gr in the exchange trophoblast of viscacha and other eutherians was constructed to map and infer phylogenetic and evolutionary relationships. Between early, midterm, and near‐term placentas, variations in the pattern expression of Gr were observed. The glycotype of the near‐term placenta is composed of a high diversity of Gr. Reconstruction of the ancestral state for each Gr present in the near‐term placenta showed a diverse scenario: some sugars were common to the species of Placentalia included in this study. In the analyzed species with synepitheliochorial and epitheliochorial placentas, no differential glycosylation patterns between them were observed. In species with invasive placentas, such as the endotheliochorial placentas of Carnivora, some common Gr were detected among them, while others were species‐specific. In species with hemochorial placenta, the same Gr are shared. Particularly, in the viscacha greater differences with species of the Hominidae and even Muridae families were observed. Nevertheless, greater similarities with other caviomorph rodents were detected. Placental glycotype of each species constitutes an excellent tool to achieve phylogenetic and evolutionary inferences among eutherians.
Contrasts Between Diffusion‐Weighted Imaging and Dynamic Contrast‐Enhanced MR in Diagnosing Malignancies of Breast Nonmass Enhancement Lesions Based on Morphologic Assessment
Authors: Li Yan , Chen Jun , Yang Zhenlu , Fan Chanyuan , Qin Yanjin , Tang Caili , Yin Ting , Ai Tao , Xia Liming
Published: February 2023

Background

Nonmass enhancement (NME) breast lesions are considered to be the leading cause of unnecessary biopsies. Diffusion‐weighted imaging (DWI) or dynamic contrast‐enhanced (DCE) sequences are typically used to differentiate between benign and malignant NMEs. It is important to know which one is more effective and reliable.

Purpose

To compare the diagnostic performance of DCE curves and DWI in discriminating benign and malignant NME lesions on the basis of morphologic characteristics assessment on contrast‐enhanced (CE)‐MRI images.

Study Type

Retrospective.

Subjects

A total of 180 patients with 184 lesions in the training cohort and 75 patients with 77 lesions in the validation cohort with pathological results.

Field Strength/Sequence

A 3.0 T/multi‐b‐value DWI (b values = 0, 50, 1000, and 2000 sec/mm2) and time‐resolved angiography with stochastic trajectories and volume‐interpolated breath‐hold examination (TWIST‐VIBE) sequence.

Assessment

In the training cohort, a diagnostic model for morphology based on the distribution and internal enhancement characteristics was first constructed. The apparent diffusion coefficient (ADC) model (ADC + morphology) and the time‐intensity curves (TIC) model (TIC + morphology) were then established using binary logistic regression with pathological results as the reference standard. Both models were compared for sensitivity, specificity, and area under the curve (AUC) in the training and the validation cohort.

Statistical Tests

Receiver operating characteristic (ROC) curve analysis and two‐sample t‐tests/Mann–Whitney U‐test/Chi‐square test were performed. P < 0.05 was considered statistically significant.

Results

For the TIC/ADC model in the training cohort, sensitivities were 0.924/0.814, specificities were 0.615/0.615, and AUCs were 0.811 (95%, 0.727, 0.894)/0.769 (95%, 0.681, 0.856). The AUC of the TIC‐ADC combined model was significantly higher than ADC model alone, while comparable with the TIC model (P = 0.494). In the validation cohort, the AUCs of TIC/ADC model were 0.799/0.635.

Data Conclusion

Based on the morphologic analyses, the performance of the TIC model was found to be superior than the ADC model for differentiating between benign and malignant NME lesions.

Evidence Level

4.

Technical Efficacy

Stage 2.
Tumor cell vaccine combined with Newcastle disease virus promote immunotherapy of lung cancer
Authors: Wang Hui , Nan Fulong , Zeng Zhou , Zhang Xueming , Ke Dingxin , Zhang Shuyun , Zhou Xiaoqiong , Niu Delei , Fan Tianyu , Jiang Shasha , Zhang Xianjuan , Wang Yunyang , Wang Bin , Zhang Wanming
Published: February 2023

Lung cancer is a fatal disease with the highest worldwide morbidity and mortality rates. Despite recent advances in targeted therapy and immune checkpoint inhibitors for cancer, their efficacy remained limited. Therefore, we designed a Newcastle disease virus (NDV)‐modified tumor whole‐cell vaccine as a therapeutic vaccine and identified its antigen presentation level to develop effective immunotherapy. Then, we calculated the therapeutic and immune‐stimulating effects of NDV‐modified lung cancer cell vaccine and intratumoral NDV injection combination on tumor‐bearing mice. The results showed that the immunogenic cell death (ICD) expression in NDV‐modified lung cancer cell vaccine stimulates dendritic cell maturation and T cell activation in vivo and in vitro. Moreover, NDV‐modified lung cancer cell vaccine combined with intratumoral NDV injection could significantly inhibit tumor growth and enhance the differentiation of Th1 cells and Inflammatory cell infiltration in vivo, leading to an excellent immunotherapeutic effect. Therefore, our results revealed that NDV‐modified lung cancer cell vaccine combined with intratumoral NDV injection could promote antigen presentation and induce a strong antitumor immune response, which provided a promising combined therapy strategy for tumor immunotherapy.
A new glutamine synthetase index to evaluate hepatic lobular restoration in advanced fibrosis during anti‐HBV therapy
Authors: Chen Shuyan , Wang Bingqiong , Zhou Jialing , Wu Xiaoning , Meng Tongtong , Liu Hui , Wang Tailing , Zhao Xinyan , Wu Shanshan , Kong Yuanyuan , Ou Xiaojuan , Jia Jidong , Wee Aileen , You Hong , Sun Yameng
Published: February 2023

Hepatic lobular architecture distortion is a deleterious turning point and a crucial histological feature of advanced liver fibrosis in chronic liver diseases. Regression of fibrosis has been documented in chronic hepatitis B (CHB) patients. However, whether lobular architecture could be restored following fibrosis regression after antiviral therapy is still unclear. Glutamine synthetase (GS) is generally expressed by perivenular hepatocytes around hepatic veins (HV). In this study, we defined abnormal lobular architecture (GSPT) as GS expressing in the vicinity of portal tracts (PT), which denotes parenchymal extinction and lobular collapse. We defined normal lobular architecture (GSHV) as GS positivity area not approximating PTs. Therefore, we propose a new GS‐index, defined as the percentage of GSHV/(GSHV + GSPT), to evaluate the extent of architectural disruption and restoration. We evaluated 43 CHB patients with advanced fibrosis (Ishak stage ≥4). Posttreatment liver biopsy was performed after 78 weeks of anti‐HBV therapy. The median GS‐index improved from 7% (interquartile range [IQR]: 0%–23%) at baseline to 36% (IQR: 20%–57%) at Week 78 (p < 0.001). Totals of 22 patients (51%) had significant GS‐index improvement from 0% (IQR: 0%–13%) to 55% (IQR: 44%–81%), while the other half had almost no change between 17% (IQR: 0%–33%) to 20% (IQR: 12%–31%). When GS‐index78w ≥ 50% was used to define hepatic lobular restoration, 37% of patients (16/43) achieved lobular restoration, with much improvement in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (median value of ∆/Baseline in ALT: restored vs. nonrestored was 79.1% vs. 48.8%, p = 0.018; median value of ∆/Baseline in AST: restored vs. nonrestored was 69.1% vs. 32.5%, p = 0.005). More importantly, lobular restoration correlated with fibrosis regression (median value of ∆/Baseline in Ishak stage: restored vs. nonrestored was 25.0% vs. 0%, p = 0.008). Therefore, in the era of antiviral therapy for CHB, restoration of hepatic lobular architecture is achievable in patients with advanced fibrosis. GS‐index provides additional insight into fibrosis regression that goes beyond collagen degradation.
Chemical profiling and quantification analysis of flavonoids in different varieties of Euryales Semen by ultra‐high‐performance liquid chromatography with tandem mass spectrometry
Authors: Li Dishuai , Cheng Xuemei , Jiang Zheng , Shi Zunrui , Qu Cheng , Yan Hui , Wu Qinan
Published: February 2023

Euryales Semen was a traditional Chinese medicine, which has been commonly used to treat spermatorrhea, enuresis, and frequent urination. Flavonoids were a critical ingredient in determining the function and quality of Euryales Semen. At present, no effective method has been established for the qualitative of Euryales Semen flavonoids. In this study, an ultra‐high‐performance liquid chromatography‐quadrupole‐time of flight‐mass spectrometry method was established for flavonoids. By comparison with standard or literature data, 32 flavonoid compounds have been identified in Euryales Semen. Based on the qualitative results, an ultra‐high‐performance liquid chromatography‐triple quadrupole tandem mass spectroscopy method was developed for the main components, and the linearity, the limit of detection, limit of quantification, repeatability, precision, stability, and recovery of the method were verified. The principal component analysis and the hierarchical clustering heatmaps analysis showed that the 30 batches of samples were distinctly separated into the North Gordon Euryale and South Gordon Euryale, and the measured contents of the six flavonoids in North Gordon Euryale were more abundant than in South Gordon Euryale, especially isoquercitrin, hesperetin, and quercetin. It provided a scientific basis for the quality control of Euryales Semen and a theoretical basis for the rational utilization of Euryales Semen resources.
Ear‐looped face masks associated retro‐auricular abscesses during the COVID‐19 pandemic
Authors: Duek Irit , Matot Sofi , Baniel Avital , Neiderman Narin N. C. , Wasserzug Oshri , Oestreicher‐Kedem Yael
Published: February 2023

Universal mask‐wearing has become public‐health recommendations and a necessity in daily life since coronavirus disease 2019 (COVID‐19) pandemic. Accumulating evidence suggests that facial masks may damage the skin. We present a series of six patients with ear‐looped face mask associated retro‐auricular abscesses (RAAs) from a tertiary referral centre, observed between March 2020 and May 2021. Patients’ past medical history included recurrent skin abscess (n = 2), seborrhoeic dermatitis (n = 1) and pre‐existing postauricular cyst (n = 4). All patients reported prolonged use of ear‐looped face masks. Incision and drainage of the abscesses were carried out in all cases, followed by systemic antibiotic treatment. All patients recovered without complications and no recurrences (follow‐up 11−17 months). We hypothesise that ear‐looped face masks may promote the formation of RAAs. Possible mechanisms include local mechanical pressure, friction, changes in the skin's temperature, humidity and microbia, inducing local inflammation and infection, leading to retro‐auricular sebaceous duct obstruction.