bluuebunny/crossref_metadata_2025 huggingface dataset:
Office Administration Simulation Media to Support Students Skill in the Freedom Curriculum
Authors: Basuki Andi , Agustina Yuli , Davis Charlotte
Published: July 2024

This study aims to develop a learning media called Stelar for practical activities to digital manage archives and create digital letters. The learning media can be accessed by three students who act as leaders, secretaries and archivists. In addition, this learning media is also designed to be monitored by the teacher. Thus, the teacher can provide an assessment in the form of numbers and important notes on the work of students. The type of this research was Research and Development using the ADDIE model, namely Analyze, Design, Development, Implementation, Evaluation. Based on the results of the application of learning media to 99 students to work on administrative activities using Stelar media, an average score of 88.5% was obtained. In addition, based on filling out a learner questionnaire to determine the effectiveness of learning media, a score of 90% was obtained. Thus, it can be concluded that the Stelar instructional media can be well accepted and is suitable for use in the learning process of Office Administration students in Indonesia. Keywords: Stelar, office administration, learning media, ADDIE
The Determinants of Financial Statement Fraud: Fraud Pentagon Perspective
Authors: Inayah Jannah Zahra , Chariri Anis
Published: July 2024

Purpose: This study investigates the determinants of financial statement fraud from the perspectives of fraud pentagon theory. It is important to study the issue within the context of state-owned companies (BUMN) as stakeholders pay a lot of attention on the companies.Method: This research is quantitative one, with a logistic regression analysis of the 16 BUMN's financial statements listed on the Indonesian Stock Exchanges for the period of five years (2018-2022). The F-Score model is adopted to measure the indications of fraudulent statement of the companies.Findings: The findings show that the five components of fraud pentagon theory do not fully determine the the indication of fraudulent financial statements of the companies. Only financial targets (FT) and CEO duality (CEOD) show significant values with negative relationship. This implies that on the context of BUMN, the five components of fraud pentagon theory do not play important roles in triggering fraudulent financial statements.Originality/Value:This paper stands out for being one of the few studies analyzing the arrogance component of fraud Pentagon theory using CEO duality. Most of previous studies on Pentagon fraud utilize CEO photographs to represent arrogance and result in inconsistent findings. Thus this paper extends current studies on the importance of using CEO duality as a proxy of arrogance.
Pengenalan Literasi Digital Pada Petani Desa Pandanmulyo Melalui Sosialisasi Digital of Agriculture
Authors: Dewi Amalia Nurma , Sholeha Mar’atus , Rohiimaa Siti , Novitasari Agnesia Nanda
Published: July 2024

Abstrak Manusia saat ini berada di tengah-tengah perkembangan teknologi yang terus mengalami perkembangan.  Hampir semua aspek dalam kehidupan sehari-hari telah dicampurtangani oleh teknologi digital, begitu juga dengan pertanian. Menggandeng salah satu start up ciptaan anak bangsa “Kerabatani”, penulis berusaha mengenalkan teknologi digital yang dapat diterapkan petani  pada sektor pertanian maupun perkebunan  di Desa Pandanmulyo. Dengan menyelenggarakan sosialisasi pengenalan digitalisasi teknologi pertanian seperti pengukuran pH, kelembaban, dan tingkat kesuburan tanah di suatu wilayah dalam satu genggaman aplikasi dan dibantu dengan alat ukur yang diciptakan oleh pihak kerabatani. Sosialisasi ini berhasil membantu warga dalam menetukan jenis tanaman mana yang sesuai dan cocok untuk tanah yang ditempati, dengan bantuan aplikasi dengan berbagai fitur yang dapat disesuaikan dengan ranah jenis pertanian warga. Sosialisasi dan pengenalan ini ditujukan untuk memberikan pengetahuan dan pelatihan penggunaan piranti digital kepada petani terkait sistem pertanian digital untuk kemajuan sektor pertanian di Desa Pandanmulyo. Kata kunci— digital of agriculture, literasi digital, teknologi pertanian Abstract Humans are currently amid technological developments that continue to develop. Almost all aspects of everyday life have been interfered with by digital technology, as well as agriculture. Collaborating with one of the startups created by the nation's children "Kerabatani", the author tries to introduce digital technology that can be applied by farmers in the agricultural and plantation sectors in Pandanmulyo Village. By holding the socialization of the introduction of digitalization of agricultural technology such as measuring pH, humidity, and soil fertility levels in an area in one hand of an application and assisted by measuring instruments created by the "Kerabatani". This socialization has succeeded in assisting residents in determining which types of plants are suitable and suitable for the land they are occupying, with the help of applications with various features that can be adapted to the community's type of farming. This socialization and introduction are intended to provide farmers with knowledge and training on the use of digital tools related to digital agricultural systems for the advancement of the agricultural sector in Pandanmulyo Village. Keywords— agricultural technology, digital literacy, digital of agriculture
inequality of 生词 meaning in comprehensive Chinese books on Indonesian learners: A translation analysis study
Authors: Dewi Endah Putri , Adhimas Yogi Bagus
Published: July 2024

This study aims to determine the inequality of Chinese translation into English and Indonesian, because differences in meaning will affect the meaning of each word translated into different languages, this difference has a very dangerous effect if there is an error in translation, one language and the other have their own characteristics and language styles, and have rules and are bound by their respective cultures and nationalities,  To minimize errors or errors in translation, it is necessary to pay close attention to the word when in a sentence it will have a different meaning when combined with other sentences.
orientation of learning Mandarin among second year students of Mandarin study program
Authors: Ventivani Aiga , Ling Ting Hie
Published: July 2024

The curriculum at the Chinese Language Study Program Malang State University is periodically reviewed once every year. The Chinese Language Study Program curriculum at Malang State University has been structured based on a Life-based Learning Curriculum. The preparation of this catalog has been attempted based on the conditions and developments at the time this catalog was published. It is intended that the curriculum used continues to develop for the better and in accordance with the needs from time to time. Curriculum improvements continue to be made in addition to adjusting needs as well so that students are able to compete and face the world of work. Therefore, the curriculum presented must keep up with the times, but not be carried away by the changing times. The purpose of this research is to find out the learning orientation of Mandarin language Chinese Language Study Program the second year students. This type of research is a type of qualitative research. Researchers want to dig up in-depth information about the orientation of students of the Chinese Language Study Program, State University of Malang, the second year students towards learning Mandarin. The results of this study indicate that second year of students consists of students who have a extrinsic and intrinsic orientations that appear side by side with instrumental and integrative orientations.
Analysis of the current situation of Chinese culture communication among Thai Chinese learners
Authors: Pataburee Tanakarn
Published: July 2024

Thailand's "Chinese craze" has developed rapidly since its formation in 2003, and the number of people learning Chinese remains high. In recent years, with the spread of Chinese, the spread of Chinese culture in Thailand has also achieved certain results. Chinese culture is increasingly valued by Chinese learners. Based on literature analysis and survey interviews, this study designs a questionnaire to study the current situation of Chinese culture communication among Thai Chinese learners. This study also analyzes the problems and difficulties faced by Chinese culture communication in Thailand, and summarizes the Chinese culture of Thai Chinese learners by means of interview method. The present study show that the Chinese culture communication strategies of Thai Chinese learners can play a certain role in the overseas dissemination of Chinese culture.
Application of Video-Based Learning Method Using Playposit Application in Chinese Listening Skill by the Students of Chinese Education Study Program State University of Malang
Authors: Rajali Muhamad , Widyatmoko Tiksno , Sakti Karina Fefi Laksana
Published: July 2024

Chinese listening skills are often used when taking Chinese language proficiency tests. Students are often the main obstacle with more dominant learning modalities will affect the motivation and interest of students during learning. The video-based learning can balances the lack of student modalities in learning. The video-based learning method with Playposit application in Chinese listening skills and to find out students' responses to the use of the video-based learning method. This research uses a descriptive qualitative method with used observation sheet and questionnaire sheet. The results of the research on the application of video-based learning methods with the Playposit application in Chinese listening skills run well and smoothly based on the existing syllabus. The application of video-based learning methods gets a positive and diverse response, because video-based learning methods can help students listen to Chinese, are more interactive, and can make students more excited when learning.
Implementation of Roleplaying Method to Train Speaking Skill of Students of Mandarin Language Education Universitas Negeri Malang
Authors: Amani Fienita , Retnantiti Sawitri , Ventivani Aiga
Published: July 2024

This study aims to describe the application of the roleplaying method to train the speaking skills of students of Mandarin Language Education Study Program State University of Malang. The theme of this roleplaying method is 学校 (school) with eight dialogs, namely (1) 新学生 (New Student), (2) 老师 (Teacher), (3) 介绍 (Introduction), (4) 上课 (Lesson), (5) 汉语 (Chinese), (6) 休息 (Break Time), (7) 学习 (Study), and (8) 作业 (Doing Assignment). This research uses a descriptive qualitative approach. The data sources in this study were 32 students of the Chinese Language Education Study Program Class of 2022. The results showed that the application of the roleplaying method in research activities went well. The results of the assessment and evaluation of the roleplaying dialog showed that most students were fluent in Chinese dialog although there were some mistakes in pronunciation of tone and intonation. Students stated that the roleplaying method was able to make students feel confident and help train students' Chinese language skills, especially in speaking and grammar skills, and make learning interesting and fun.
Aproximación a la relación sino-europea a través de las diferentes traducciones de Historia del gran reino de la China de Juan González de Mendoza
Authors: Bo Gao
Published: July 2024

Desde hace cinco siglos, la obra Historia del gran reino de la China de Juan González de Mendoza siempre ha ejercido una gran influencia en la comunidad académica internacional. Este artículo toma como punto de partida la trayectoria de la traducción al chino del libro, y pretende interpretar la interrelación entre las ediciones de la traducción al chino y el proceso histórico de las relaciones sino-europeas desde el trasfondo político, económico y social, puesto que cada representación del libro de Mendoza brinda una interpretación actualizada del proceso contemporáneo de las relaciones chino-occidentales.
Preferencias y valoraciones de los universitarios hispanohablantes sobre los manuales didácticos de lengua china
Authors: Jia Lin
Published: July 2024

En España, en 2018, la cantidad de alumnos españoles de lengua china superaba los 40,000 y cada vez más universidades ofrecen asignaturas de chino mandarín tanto en el grado como en el máster. Este aumento también ha causado un gran interés por el uso y la elaboración de los manuales didácticos del idioma chino en el campo académico. El Nuevo Libro de Chino Práctico, siendo el manual más usado en las universidades españolas durante más de 20 años, ha sido un manual ejemplar y excelente de la lengua china, no obstante, su utilidad en algunos aspectos de la enseñanza de idiomas no se adecúa a los tiempos actuales. Por lo tanto, en este estudio, se ha llevado a cabo un cuestionario dirigido a 68 estudiantes universitarios españoles de grado, que tienen como primera lengua extranjera el chino mandarín, con el fin de conocer sus preferencias, opiniones y valoraciones sobre el Nuevo Libro de Chino Práctico. Los resultados obtenidos permiten proyectar una base para la creación de los futuros manuales didácticos de chino y aplicar métodos avanzados de enseñanza.
Estudio contrastivo de los cuantificadores universales en español y sus homólogos en chino
Authors: Shi Hui
Published: July 2024

Dentro del rango de los cuantificadores, los cuantificadores universales forman una parte especial, dado que expresan la totalidad de unidades. Existen tres cuantificadores universales en español: todo/a(s), cada y ambo/as. De este modo, el principal objetivo de este trabajo es realizar un estudio contrastivo de las tres palabras en español y sus homólogos en chino mandarín a partir de las perspectivas de la sintaxis y la semántica, examinando los datos de la literatura revisada, de dos corpus, CORPES (Corpus del Español del Siglo XXI) de español y BCC (BLCU Corpus Center) de chino, y de introspección. Después de revisar brevemente los diferentes usos frecuentes de la palabra 都 dōu en las oraciones de cuantificación universal y declarar el punto de partida de este artículo, se realiza un análisis comparado uno por uno y captar las similitudes y diferencias de los cuantificadores universales en español y sus homólogos en chino mandarín. Además, se ofrece una observa de algunas formas particulares que expresan la cuantificación universal en el chino mandarín.
Emergence, Evolution, and Outcomes of Community-Based Conservation Behaviors in Coastal Systems
Authors: Clark Matthew C.
Published: July 2024

This body of work leverages a variety of quantitative and theoretical approaches to advance our understanding of why individuals adopt community-based conservation behaviors, the impacts those decisions have on natural resources and human wellbeing, and how these insights can be used for practical conservation planning. The first chapter makes a theoretical contribution by fitting data produced from a stylized, agent-based simulation of conservation adoption over time with a set of probabilistic differential equations derived from the theory of diffusion of innovations and cultural evolutionary theory broadly. We use these methods to demonstrate that such a statistical approach can provide accurate inference and prediction around the rates and degree of behavioral adoption within a population even when behavioral uptake is contingent on dynamic feedback processes between human behavior, social learning, and environmental change. The second chapter introduces approximate Bayesian computation as a method for linking hypothesized causal processes in complex land systems with observed changes in the mosaic of land cover. This chapter uses the small-scale agricultural production system in Pemba Island, Tanzania as a case study, identifying that soil degradation is likely the primary driver of agricultural expansion into nearby coral rag forests. The third chapter relies on an extensive data collection campaign in 43 communities across Pemba to measure individuals’ perceptions of mangrove cover change and risk of mangrove theft, and to assess their impact on individuals’ conservation behaviors and preferences. The results of this study indicate that perceptions of mangrove decline drive individual adoption of conservation behaviors and preferences only if they believe that the resultant gains in mangrove cover will not be stolen by outsiders. Conversely, individuals who believe their community mangrove forests are at high risk of theft actually decrease their support for forest conservation in response to perceived forest decline. Lastly, the fourth chapter explores the alignment and misalignment between individual perceptions of mangrove cover change in Pemba and remotely sensed observations of cover change over the same time period. We qualitatively examine the reasons for mismatches in the two data sources and propose a numerical optimization method for considering both sources of information in systematic conservation planning. Together, these studies contribute to the advancement of both theory and methods in studying human behavior within complex social-ecological systems, primarily in small-scale fishing and agricultural communities. Overall, the research presented underscores the importance of understanding human behavior for effectively implementing conservation strategies, and provides valuable insights for informing future conservation planning and interventions.
A DNA Aptamer Transducer Designed Toward Rapid Biosensor Development
Authors: Hachigian Timothy Z.
Published: July 2024

Aptamer-based biosensors have garnered significant interest due to their versatility in detecting a wide range of analytes across various applications. In this work, a customizable Aptamer Transducer (AT) was introduced as a non-enzymatic and modular duplexed aptamer biosensing platform. The design modularity was accomplished by separating the aptamer input domain from the output domain. The AT was demonstrated to be capable of fully transducing an adenosine signal into arbitrary DNA outputs using a structure-switching aptamer design. The AT design utilized strand displacement reactions via toehold mediated strand displacement with fluorescence based reporting for signal detection. Furthermore, the AT was incorporated with two catalytic amplification networks to further demonstrate its customizability. In a subsequent study, the kinetic behavior and performance of modified ATs were investigated, and a high-throughput approach was developed for modifying ATs toward improving sensitivity based on an aptamer complementary element selection method. Modular biosensing platforms based on duplexed aptamers are advantageous for rapid development of low-cost tests since sensing and output domains can be easily customized, and studies that aim to develop such platforms are beneficial for the future development of selective and sensitive assays.
Stalking Victimization
Authors: Neef Abigail
Published: July 2024

Stalking victimization is receiving increasing attention in the media and research. Though research knowledge is growing there are still many aspects of stalking victimization that are not fully understood. This study aims to bring together two literatures relating to stalking: research on the role of victim-offender relationship and research on the emotional effects of stalking on victims. Using 2019 Supplemental Victimization Survey data, this study examines the direct relationship between victim-offender relationship and emotional distress. Findings indicate that victims who were stalked by a current intimate partner express more indicators of emotional distress than victims stalked by a personal acquaintance, a formal acquaintance, stranger or someone they were unable to identify. Implications of these findings are discussed.
Poly(alkyl Aldehyde)s
Authors: Nogales Kyle Arnold
Published: July 2024

This dissertation will describe a new class of closed-loop recyclable, self-immolative polymers that undergo selective, complete, and rapid depolymerization in the solid state when triggered. Self-immolative poly(alkyl aldehyde)s are synthesized efficiently in approximately 60% yield using anionic polymerization, which provides access to polymers in accessible lengths ranging from short (Mn value of 2 kDa) to long polymers (Mn value of 5,000 kDa). The physical and thermal properties of the polymers can be tuned rationally by appropriate choice of the aldehyde monomer, with some of the polymers displaying mechanical properties that are similar to traditional plastics. The polymers depolymerize within minutes when the end-cap (i.e., detection unit) is cleaved from the polymer in response to a specific applied signal, where the signals can be selected from base (with a hydrogen end-cap) or fluoride (silyl ether end-cap). Poly(alkyl aldehyde)s also depolymerize readily in the solid state when heated above the degradation temperature, which enables direct, low-energy, closed-loop recycling of polymeric materials by converting plastics to monomers without dissolving the plastics. These favorable properties, coupled with the low cost and wide availability of aldehyde monomers, makes poly(alkyl aldehyde)s promising candidates for replacing certain types of traditional plastics that are difficult to recycle.
Risk Assessment and Solutions for Two Domains
Authors: Parker Kamryn DeAnn
Published: July 2024

Risk is something that surrounds us each and every day, and learning how to manage risk in different areas is necessary to limit its impact. Two different areas of risk have been identified for this thesis: election day incident infrastructure and user privacy disclosure prevention. We ask if it is possible to leverage information related to risk to create procedures that handle it as an overall issue in order to apply procedures to similar areas of research. Understanding how to identify and prevent these potential areas of risk is important to secure information not just for a single person, but potentially for whole populations. Developing plans of action to prevent severe problems within these areas may improve not only election day incident communication but also personal trust in technology to share private information accurately.

This thesis proposes interdisciplinary techniques through qualitative analysis, quantitative analysis, and machine learning tools to build solution frameworks for these unique challenges. In Idaho, communication between election officials is currently broken when dealing with problems on election day. Many times, officials use multiple streams of communication (i.e., text, calls, emails, etc.) to relay information to one another. This fractured process risks the inability to track the progress made on incidents, the potential inefficiency with resolution, and information loss between different communication streams. Therefore, we interviewed election officials from multiple states to assess the need for a centralized incident management and communication tool to assist in incidents. The security of personal information is an important part of the identity of a person or organization. If private information is leaked unintentionally to incorrect audiences, it could reflect poorly on the person or organization. Therefore, we analyze how to prevent the risk of undesirable privacy disclosure using unsupervised and transfer learning techniques to leverage public and private information for prediction.

The results pointed favorably to the implementation of a communication tool for election administrators to assist with efficient communication and response to election day problems. Learning outcomes and best practices for preventing unwarranted private information disclosures to users will also be presented. Further analysis is recommended to implement these contributions in real-world environments.
IL13Ra1 Drug Discovery
Authors: Pugel Anton
Published: July 2024

Parkinson’s Disease (PD) results from the loss of dopaminergic (DA) neurons within the substantia nigra. Current treatments attempt to replace the function of DA neurons instead of preventing their loss. Interleukin 13 receptor alpha 1 (IL13Ra1) was identified to be upregulated in PD. IL13Ra1 knockout mice were observed to be resistant to DA neuron loss under a chronic inflammation model. IL13Ra1 dimerizes with interleukin 4 receptor (IL4R) through the binding of either interleukin 4 (IL4) or interleukin 13 (IL13). In-silico screening was utilized to identify 40 low weight compounds that could target IL13Ra1-IL4R. To identify the drugs’ effects on IL4/IL13 signaling, an A549 cell line was treated with a drug and IL4/IL13 then pSTAT6 levels were quantified. Drug 4 and Drug 26 were observed robustly inhibiting IL4/IL13 signaling. Cytotoxicity was assessed using resazurin and lactate dehydrogenase survival assays. Drug 26 had observed cytotoxicity while Drug 4 had little to no observed cytotoxicity. Drug 4 was determined to be the lead drug for the remaining tests. Compounds structurally related to Drug 4 were also tested. We observed inhibitory effects on IL4/IL13 signaling testing with nicotine, niacin, and NAD. Our data suggests that Drug 4 is a promising nutraceutical candidate for future IL13Ra1 inhibition studies.
Fair Layouts in Information Access Systems
Authors: Raj Amifa
Published: July 2024

Information access systems, such as search engines and recommender systems, often display results in ranked order based on their estimated relevance. The fairness of these rankings has received attention as an important evaluation criteria along with traditional metrics capturing constructs such as utility or accuracy. Fairness has many facets, including provider and consumer-side fairness at both group and individual levels. Research on provider-side group fairness involve concerns regarding measurement and optimization of fairness in ranking. Although there are several fair ranking metrics to measure provider-side group fairness based on various “sensitive attributes”, multiple open challenges still exist in this area to consider. Moreover, the fair ranking research mostly focuses on linear layouts when items are displayed in single-column list, often overlooking fairness issues in other layouts such as grid view.

In my dissertation, I work on the area of provider-side group fairness in ranking in information access systems. I seek to understand the fairness concepts and practical applications of existing fair ranking metrics and find ways to improve the metrics. My work wilaid researchers and practitioners in selecting fair ranking metrics by pointing out the strengths, limitations, applicability and reliability of the metrics. Moreover, I contribute to the advancement of fair ranking metrics by considering various ranking layout models and further contribute to provider-side group fairness optimization in ranking in widely-used but seldom-studied grid layout.
Characteristics of Stream Source Water Contributions and Associated Geochemical Signatures Along a Climate and Vegetation Gradient in a Glacierized Landscape, Southcentral Alaska
Authors: Richardson Hannah K.
Published: July 2024

Mountain-derived snow and ice melt are essential for global water resources, and over one-sixth of the population depends on melt for freshwater. Rising air temperatures are causing vegetation to replace snow- and ice-covered landscapes and precipitation regimes to change. Collectively, these changes will alter the hydrology of mountain environments, although the exact impacts to hydrologic regimes are poorly understood. The source waters of streamflow (i.e. the proportion of ice melt, snowmelt, rain, and groundwater) dictate the timing and magnitude and affect temperature, sediment, and nutrient fluxes. By examining differences in source waters across basins with varying land covers and precipitation regimes, we can better predict the impact warming temperatures may have on streamflow from both a physical and biogeochemical perspective. Glaciers also physically weather their environment, which increases chemical weathering potential. High chemical weathering rates can impact global carbon cycling, but the extent and net influence of their impact is unknown. This thesis examines shifting source water contributions and chemical weathering patterns in sub-watersheds of the Nellie Juan basin on the Kenai Peninsula in Southcentral Alaska that range in percent glacier cover, elevation, and land cover type. To do so, a variety of geochemical, remote sensing, and modeling techniques were used. I found strong relationships between elevation, source water contributions, and land cover. There were also clear differences in the timing of snow and ice melt contributions to streams between glacierized and non-glacial streams. Groundwater is shown to be a major contributor to streamflow across the basin and may become increasingly important as snowpack and glacier melt decrease. Geochemical analyses show that the main driver of weathering-derived solutes in the region is bedrock type and that the presence of the glacier seems to play only a minor role in weathering. I also find a positive relationship between the proportion of groundwater in streamflow and weathering-derived solutes. This research characterizes the shift from a glacial to a deglaciated landscape through the lens of source water contribution and geochemical weathering regimes. Broadly, these findings can help improve our understanding of how water resources, biogeochemical fluxes, and carbon cycling in glacierized basins are impacted by warming air temperatures.
Challenges to adopt Blockchain technology in the Gulf Cooperation Council Countries
Authors: Alshhadat Mohammad ,   Accounting Department, Mutah University’s Business School, Mutah, Jordan
Published: July 2024

This study examines the challenges face blockchain technology adoption by companies operate in Gulf Cooperative Council Countries (GCC). The qualitative approach was utilized to understand the phenomenon. Accordingly, 38 interviews have been conducted with experts, businesses senior managers, professionals and analysts to deeply inquire into the reasons behind reluctance of GCC companies to adopt blockchain technology. The present study adds an original contribution to theory by concluding some very interesting information that facilitates the understanding of the challenges that prevent companies operate in GCC region from benefiting from blockchain technology. These basically come under three dimensions, namely cultural reasons, economic feasibility, and vagueness of the regulatory environment of blockchain technology and its future. This study provides some implications for industry and policymakers to help them to provide venue for proper implementation of this promising technology.
A clinical, cyto-histopathological and immunohistochemical study of spindle cell lesions of breast in a tertiary care hospital
Authors: Khan Arshi , Afroz Nishat , Khan Roobina , Maheshwari Veena , Harris Syed Hasan
Published: July 2024

Spindle cell lesions in the breast are a diverse group of entities that can be either benign or malignant. Spindle cell lesions often pose a challenge to the diagnosing clinician because of the vast differential diagnoses, the rarity of these lesions and the histological similarities. We aim to conduct this study to profile these rare lesions of the breast and correlate the cyto-histopathological features on FNAC with immunohistochemical characteristics to determine its efficacy.

A total 260 patients, suffering from spindle cell lesions of the breast, attending the outpatient and in-patient services were included in this 5 year study (3 years of retrospective cases and 2 years of prospective cases) conducted at Department of Pathology, JNMCH, AMU, Aligarh.

: Only Diagnosed cases of Spindle cell lesions of breast were included in the study. The study sample comprised of 260 cases (105 cytological cases and 220 histopathological cases with 65 cases that are common to both)

Apart from diagnosed cases of Spindle cell lesions of breast all other breast lesions either reactive benign or malignant were excluded.

Total number cases of breast lesions received in the Department of Pathology during 5 year study period were 15,270 out of which 9700 cases were of Histopathology and 5570 were of Cytopathology. Among 15,270 cases, a total number of 15,010 (98.29%) cases belonged to non-spindle cell lesions which were excluded from the study and the remaining cases i.e., 260 (1.7%) cases diagnosed as spindle cell lesions of breast constituted the study group. Of the total260 cases, 105 cases were of cytopathology and 220 cases were of histopathology and cases common to both i.e., those cases which had cyto-histopathological correlation were 65 cases (20%). The highest incidence of spindle cell lesions occurred in 4 decade of life comprising of 126/260 cases (48.46%).

Spindle cell lesions are not so common in breast, accounts for 1.7% of cases only. The workup involves thorough histopathological examination due to considerable morphological overlap and an elaborate IHC studies since no single Immunohistochemical marker is sufficient/specific to clinch the final diagnosis. Hence, it is difficult to make the final diagnosis of spindle cell lesions of breast on histopathology alone in majority.
Thyroid isthmus agenesis: An uncommon yet clinically relevant entity
Authors: Rawat Garima , Shukla Aditi , Aiyer Hema Malini
Published: July 2024

The thyroid, a crucial endocrine gland composed of two lobes connected by isthmus tissue, rarely exhibits isthmus agenesis or hypoplasia, conditions scarcely documented in medical literature. This discussion centers on a 54-year-old female patient whose incidental discovery of isthmus agenesis occurred during surgery for a multinodular goiter. Identification of isthmus abnormalities prompts thorough consideration of potential associated anomalies, including hypoplasia, absence of a thyroid lobe and the presence of ectopic thyroid tissue. Increased awareness of potential isthmus agenesis or hypoplasia and associated thyroid anomalies among patients scheduled for thyroid surgery is essential for improving procedural safety and reducing the risk of complications related to surgery.
Sporadic non-ampullary duodenal adenoma with high grade dysplasia: A rare case report
Authors: Dahiya Surbhi , Malik Ajay , Singh Shushrut
Published: July 2024

Duodenal adenomatous polyps are usually classified according to the mucin phenotype into intestinal (89.1%) and gastric type (10.9%). The intestinal-type polyps are morphologically divided into tubular and tubulo-villous adenomas, whereas the gastric-type into pyloric gland adenomas and foveolar adenomas. The duodenal adenomas are also clinically categorised into sporadic duodenal adenomas and adenomas associated with genetic syndromes for instance familial adenomatous polyposis (FAP), or MUTYH associated adenomatous polyposis (MAP). Sporadic duodenal adenomas are less common than FAP related adenomas and are usually recognized in elderly men in their 6 to 8 decade of life. The large non-ampullary solitary duodenal adenomas ≥ 20 mm in diameter with high grade dysplasia show a significantly high risk of progression to adenocarcinoma and therefore, must be treated immediately. Our case, is a middle-aged female who presented with symptoms and had an exophytic duodenal mass of about 60mm in diameter, microscopically showing tubulo-villous intestinal pattern with high grade dysplasia and no breach in muscularis mucosae, thereby making it a case with distinct presentation and characteristics.
Giant Bowen’s disease of anterior abdominal wall with invasive squamous cell carcinoma-A rare case report
Authors: Prabhala Shailaja , Palo Seetu , Rath Ashutosh , Rao Siddharth , Konda Deepthi
Published: July 2024

A 65 years old male presented to the out-patient department of Dermatology with complaints of a large verruco-erosive lesion on left anterior abdominal wall for 15 years. A wedge incision biopsy was done which showed features of Bowen’s disease. The patient was referred to department of General Surgery where a complete excision was done. The final histopathology report confirmed the diagnosis of Bowen disease with a focus of invasive carcinoma component. This case report is unusual for its clinical presentation, duration and location of the lesion.
Insulinoma- Rare pancreatic tumor
Authors: Kumar Rajat , Kumari Khushbu
Published: July 2024

Insulinoma is hormone producing neuroendocrine pancreatic tumor. Insulinoma is a type of functional neuroendocrine tumor characterized by hypersecretion of insulin, causing hypoglycemia. It typically presents as a solitary benign tumor but can be associated with multiple endocrine neoplasia type 1 (MEN1). Patients with insulinoma have hypoglycemic episodes, more characteristically as fasting hypoglycemia.

46 yrs. old male having recurrent episode of Syncopal attack, sweating, excessive thrust, and weakness last 3 to 4 yrs. His blood sugar level was always below normal range at time of attack. No H/O diabetes, Hyper tension or any other chronic illness.

On detail examination and investigation, we found that his blood sugar level fall 01 hrs. After food intake and blood sugar fasting and post prandial (F=46 mg/dl & PP= 180 mg/dl) is impaired. C Peptide level, serum insulin level is high. MRI shows growth near head of pancreas.

Partial pancreatectomy done and sample send for histopathological examination which shows well differentiated pancreatic neuroendocrine tumor with no lymph node involvement and congested spleen.

The Whipple triad, named after the American surgeon Allen O. Whipple (1881-1963), is the diagnostic hallmark establishing the existence of a hypoglycemic disorder and has the following 3 features: (1) symptoms, signs, or both consistent with hypoglycemia; (2) low plasma glucose measured at the time of the symptoms and signs; and (3) relief of symptoms and signs when the glucose is raised to a normal level (2, 3). Insulinoma is usually diagnosed by biochemical testing. Surgical resection is the preferred treatment choice.
Co-relation of hepatitis C RNA load with antiviral therapy and risk factors among hepatitis C seropositive patients
Authors: Netam Suchita , Priyadarsini Kshyudratika , Sherwani Nikita , Chandravanshi Suresh , Singh Neha , Sahu Aparna
Published: July 2024

Hepatitis C virus is a bloodborne virus and the major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma. Viral load is the prognostic marker of the disease progression. The aim of this study is to determine the correlation of hepatitis C RNA load with antiviral therapy and its risk factors among the HCV seropositive patients. This study will be helpful in early assessment of the disease progression and its complications.

The blood samples were collected over a period of one year from April 2022-March 2023. The serum was subjected to ELISA for Anti HCV Ab. Viral load quantification was done by MylabPathoDetect HCV Quantitative PCR Kit in HCV seropositive patients.

About 18,882 patients were tested for HCV infection over a period of one year. 75 patients were positive for HCV infection. Prevalence of HCV was 0.39. The mean viral load was reduced from 3.08×10 IU/ml to 1.98×10 IU/ml and Sustained Viral Response (SVR12) was achieved in 63(84%) patients after effective treatment with direct acting antiviral agents. High risk sexual behavior was the most common risk factor observed in seropositive patients.

The current study determines the reduction in mean viral load and achieving sustained viral response after the effective antiviral therapy at the earliest, which is helpful in prevention of disease progression and its complications.
Bacteriological profile of bloodstream infections in pediatric age group in a tertiary care centre, Solapur
Authors: Waghmare Prakash Hindurao , Mukherjee Nilanjana , Shinde Deepak K , Chincholkar Vijaykumar V
Published: July 2024

Bloodstream infections (BSI) due to multidrug-resistant organisms from paediatric setup have become increasingly common. BSI can be transient and be rapidly cleared out by the host defence mechanism or be associated with high morbidity and mortality if it becomes persistent.

Blood samples were collected from 1112 children within a 1-year study period (July 2022 to June 2023) which included all children admitted with complaint of fever and suspected of having sepsis in Paediatric department of Shri Chhatrapati Shivaji Maharaj Sarvopchar Rugnalaya (SCSMSR), Solapur. Blood volume was collected depending upon age and body weight of the patient with aseptic precautions and inoculated in Brain Heart Infusion broth (BHI) which was incubated at 37°C for 7 days. Subcultures were made on blood agar and MacConkey agar plates. Organisms were identified by biochemical reactions and antibiotic susceptibility test of the isolates were performed by disk diffusion.

Out of 1112 suspected cases, 175 (15.74%) were culture positive. (27.43%) was the most common isolate followed by (16.57%) Most common Gram positive isolate was (11.43%) followed by (6.86%). Total Multidrug resistant (MDR) isolates in Gram negative and Gram positive were 50.35% and 31.25% respectively.

High rates of antibiotic resistance are observed in both gram positive and gram negative organisms. Thus, there is an urgent need for proper implementation of antibiotic stewardship programme and infection prevention and control measures.
Aprendizagem Baseada em Jogos e Pensamento Computacional no Ensino Fundamental: um Mapeamento Sistemático da Literatura
Authors: Nipo Daniel , Rodrigues Rodrigo , França Rozelma , Nascimento Josevandro
Published: July 2024

O Pensamento Computacional consiste em habilidades, baseadas na Ciência da Computação, que auxiliam na resolução de problemas. O desenvolvimento de Pensamento Computacional pode ser estimulado através de diversos recursos, dentre eles os jogos digitais. Os jogos digitais se destacam como parte do cotidiano das pessoas, são capazes de motivar quando usados no ensino e aprendizagem, aumentando o interesse dos alunos. Este trabalho apresenta um Mapeamento Sistemático da Literatura, tendo como questão central "Qual o estado atual das pesquisas científicas centradas nas relações entre Aprendizagem Baseada em Jogos e Pensamento Computacional no contexto do ensino fundamental?". Os achados do mapeamento revelaram tendências e lacunas a serem exploradas em pesquisas futuras.
 
Palavras-chave: Pensamento computacional. Aprendizagem baseada em jogos. Ensino fundamental. Mapeamento sistemático.
Parenting in Late Antique Society (Based on the Writings of Ausonius)
Authors: Timchenko Aleksandra V. ,   Belgorod State National Research University
Published: July 2024

The article explores the autobiography of the 4th-century poet Ausonius, as well as the issue of the relationships between parents and children, and between spouses. The views of the rhetorician on family values, parental responsibilities towards children, child-rearing and education, as well as their social status, are analyzed in the article. The author concludes that Ausonius considered the life path of a person as a sequence of stages, each of which includes unique challenges and difficulties. Assessing the role of the family in formation of personality, he notes that the upbringing and education of children required direct involvement and attention from the parents.
Formation and Development of the Psychiatric Clinic of Voronezh State University in the 1920s
Authors: Bakhtin Viktor V. ,   Voronezh State Medical University named after. N.N. Burdenko of the Ministry of Health of the Russian Federation, Bakhtina Anastasia V. ,   Voronezh State University
Published: July 2024

The article examines the evolution of the psychiatric clinic of Voronezh State University (VSU) from the evacuation of Dorpat University to Voronezh until the reorganization of VSU in 1930 and the creation of an independent Voronezh Medical Institute on the basis of the Faculty of Medicine. A brief analysis of the activities of the heads of the Yuryevsky (Derpsky) clinic and Voronezh universities is given.
La Chimba de Santiago: de Arcadia Colonial a Heterotopía Sanitaria
Authors: Baros Townsend Mauricio , Campos Gajardo Alicia
Published: July 2024

La idea de Arcadia ha sido una gran utopía que encuentra sus raíces en la cultura griega, sin embargo, se ha utilizado en diversos momentos de la historia occidental, para referir un ideal paradisiaco de la vida bucólica, conectado con los entornos naturales apartados de la ciudad.
Sobre la dimensión estética y semiótica del habitar urbano y su vínculo con el diseño y el territorio social
Authors: Cortés López Claudio
Published: July 2024

Este artículo explora desde la teoría, como se da la dimensión estética y semiótica del habitar urbano y su vínculo con el diseño.
Definiendo el Territorio como Proyecto, enfoque de diseño regenerativo para proyectar futuros alternativos de cohabitar socio-ecológico
Authors: Lares Lopez Lorna
Published: July 2024

La evidencia científica es irrefutable y ha demostrado el impacto de la actividad humana sobre el planeta, dando cuenta que las formas de vida dominantes no son sostenibles, desencadenando el agotamiento de los recursos, la sobreproducción, el sobreconsumo y la sobreabundancia de desechos que han contribuido a la actual crisis ambiental y social.
Una diversidad de modernidades. Sobre algunos despliegues de las nociones de lo Moderno
Authors: del Valle Luis Andrés
Published: July 2024

El fenómeno de la Modernidad sigue siendo hoy parte de un debate, el cual ha proseguido, y a la vez ha renovado, las discusiones del siglo pasado.
Expresiones modernas en la arquitectura de Guayaquil a inicios del siglo XX
Authors: Compte Guerrero Florencio
Published: July 2024

Así como hay relatividad en la definición de lo que es la modernidad, ha habido también una indefinición en la arquitectura moderna al relacionarla con un conjunto de patrones formales, sin entender que su expresión se da como reflejo de un momento histórico determinado por las condiciones económicas, sociales, políticas, culturales y tecnológicas particulares de cada lugar donde se desarrolla.
Sobre la educación, el diseño, el territorio, la inclusión y la sustentabilidad
Authors: Wolkowicz Daniel
Published: July 2024

El siglo XXI trajo cambios profundos en la educación, con enfoques innovadores y desafíos constantes.
La discapacidad y sus nuevos postulados en el escenario mundial
Authors: Urroz Gisela , Apollonio Adriana , Álvarez Alejandra , Mercuri Marcela , Godoy María Eugenia , Giordano Martín , Achar Luz , Mikulan María
Published: July 2024

La Accesibilidad como condición de diseño para el Hábitat Humano, es un Derecho que requiere de conocimiento y formación de los profesionales que tendrán en sus manos la decisión en la creación de los entornos, productos y servicios que la conforman.
Del periodismo impreso al digital: Nuevas posibilidades para la comunicación del diseño
Authors: Fibbiani Marcela L.
Published: July 2024

Este artículo investiga la generación de noticias sobre diseño en la era de las redes sociales. Se analiza el rol no sólo del periodista especializado sino también la aparición de otros comunicadores como curadores, diseñadores y fanáticos no formados académicamente como periodistas, pero que a través del ejercicio continuo, crean comunidades virtuales sólidas.
Entreascuas. Investigación artística y diseño editorial a partir de los libros de Isidoro Valcárcel Medina
Authors: Insúa Lintridis Lila
Published: July 2024

Entreascuas es una editorial especializada en publicaciones de artistas que se constituyó en el año 2001 para afrontar la tarea de lanzar el libro de Isidoro Valcárcel Medina, (I.V.M.) 2.000 d. de J. C. Este libro, extensísimo y de un contenido iluminador no tenía quien lo publicara, sólo podía hacerlo otro artista de la misma envergadura: Jaime Vallaure.
La Cultura de Diseño, un circuito en permanente transformación
Authors: Viera Edisson
Published: July 2024

El estudio pretende identificar las principales líneas de conexión de la cultura de diseño en su relación con el sector industrial en el performance empresarial, como una herramienta competitiva, a través del valor agregado, y de esta manera construir límites en ecosistemas de producción, mediante encontrar respuesta a ¿Qué se hace? Y ¿Cómo se hace?