bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of behavioral biases in the investment decisions of Pakistan Stock Exchange investors: Moderating role of investment experience
Authors: Aziz Saima , Mehmood Shahid , Asif Khan Muhammad , Tangl Anita
Published: February 2024

Despite many revolutionary asset pricing models developed over the past decades, traditional finance does not explain investor behavior very well. The purpose of this study is to examine the influence of behavioral biases on the investment decisions of investors of Pakistan Stock Exchange. In addition, the moderating influence of investment experience investigated in this study. The findings were reported using a sample of 230 individual investors, who make their own investments, typically through a mutual fund, bank, or internet broker. They make investments to achieve their unique investment objectives, such as saving for retirement, a child’s education, or increasing their overall wealth. The influence of behavioral biases on investment decisions was calculated using regression analysis. Regression results show that beta and t-values are significant and have a significant impact on investment decisions. Regression findings show that Confirmation Bias, Gamblers Fallacy Bias, Negativity Bias, Bandwagon Effect Bias, Loss Aversion Bias, and Overconfidence Bias all have a substantial impact on Investment Decisions. Status quo prejudice and endowment bias have a favorable but minor influence on Investment Decisions. Investment Experience is regarded as an essential component that contributes to successful decision making under risk and uncertainty, however the results of this study show that moderating variables have a minor influence. According to the findings, the moderating variable had no effect on the connection between behavioral biases and investment decisions. And the reason for this is that behavioral biases persist regardless of investing experience.
Sobre o Problema de Previsão de Qualidade de Ar com Modelos de Aprendizagem de Máquina
Authors: Brito Eliseu , Mghazli Ya-Sin , Seixas José Manoel , Araújo Ricardo
Published: February 2024

Neste trabalho e apresentado um estudo empírico sobre as características do fenômeno gerador de séries temporais relacionadas a qualidade do ar. Baseado neste estudo, serão investigados modelos baseados em aprendizagem de máquina para solucionar este tipo particular de problema de previsão. Por fim, uma análise comparativa ser a realizada com os modelos investigados conduzindo-se experimentos com um conjunto relevante de problemas de previsão de qualidade do ar relacionado a concentração de poluentes atmosféricos coletados a partir de sensores da United States Environmental Protection Agency.
Decoding the Christian Era of Dionysius Exiguus
Authors: Naumowicz Józef
Published: February 2024

Dotychczas nie znaleziono satysfakcjonującego wyjaśnienia, w jaki sposób rzymski mnich Dionysius Exiguus ustalił rok narodzenia Jezusa w swoim systemie rachuby lat, który wprowadził w 525 roku. W badaniach dominują bowiem dwa bezzasadne założenia: pierwsze, że twórca tej rachuby nie podał jej uzasadnienia, i drugie, że rozwiązania problemu należy szukać jedynie w pracach tego autora dotyczących obliczania dat Wielkanocy. W tym artykule przyjąłem następującą hipotezę badawczą: wyjaśnienie nowej rachuby lat znajduje się w pismach Dionizego, do których należą jego prace komputystyczne, ale także teologiczne. Analiza tych pism pozwala odkryć historyczne i teologiczne racje, które stały się faktyczną podstawą ustalenia daty narodzenia Jezusa na rok odpowiadający dzisiejszemu AD 1.
Computational and In vitro Elucidation of Indolenine-barbituric Acid Zwitterions as Potential Chemotherapeutical Agents
Authors: Ong Kang Kit , Ramle Abdul Qaiyum , Ng Min Phin , Lim Siew Huah , Sim Kae Shin , Tan Chun Hoe
Published: February 2024

Introduction:

The continuous pursuit of novel chemotherapeutical agents with improved
efficacy and reduced adverse effects remains a critical area of research despite advancements in
chemotherapy. We have previously synthesized indolenine and barbituric acid zwitterion scaffolds
1–10 sustainably; however, their precise chemotherapeutical properties are still lacking.

Methods:

In this present work, we conducted in silico ADMET analyses, molecular docking calculations,
DNA binding studies, and cytotoxicity assays on these zwitterions.

Results and Discussion:

Among the 10 zwitterions, zwitterion 3 bearing a methoxy group demonstrated
the highest drug-likeness score, low toxicity, as well as no violation of Lipinski’s rule of five
and Veber’s rule. Both molecular docking calculations and DNA binding studies suggested that the
minor groove of DNA is the most probable molecular target of 3 among the others (i.e., topoisomerase
and tubulin). In addition, zwitterion 3 exhibited selective cytotoxicity against a wide array of
human cancer cell lines without noticeable effect against the normal human colon fibroblast CCD-
18Co.

Conclusion:

Overall, these preliminary findings from our combined computational and experimental
strategy suggested that 3 remains promising for further elaboration as a chemotherapeutic agent.
Borderline Brenner Tumor of the Ovary in a Postmenopausal Woman: A Rare Case with Concomitant Endometrial Hyperplasia and Endocervical Polyp
Authors: Kumar Naina , Pradeep Immanuel , Srirambhatla Annapurna , Poojitha K. , Mangla Mishu
Published: February 2024

Introduction:

Bordeline Brenner tumors of the ovary are rare tumors accounting for 2% of
all ovarian tumors and are characterized by the presence of papillary structures covered with transitional
epithelium without or minimal stromal invasion.

Case Presentation:

In the present case report a 60-year-old postmenopausal woman presented with
complaints of lower abdominal pain and a right ovarian mass of 4x5cm, which was diagnosed on histopathological
examination as borderline Brenner tumor of the ovary. There were coexisting nonatypical
endometrial hyperplasia and endocervical polyps of 1.2x0.9x0.6cm, indicating endometrial
hyperstimulation as a result of estrogen secreted by the tumor. The patient was managed successfully
with staging laparotomy and was diagnosed with stage I borderline Brenner tumor with non-atypical
endometrial hyperplasia and benign endocervical polyp.

Conclusion:

Borderline Brenner tumors are rare tumors of ovaries with uncertain malignant potential.
They have no precise predictive markers but are known to produce estrogen. Surgery remains the
mainstay of treatment for these tumors.
Unravelling the Impact: Pulmonary Side Effects of Anti-Seizure Medications
Authors: Butera Ambra , Pirrone Martina , Accetta Arianna Santina , Consoli Carla , Nicotera Antonio Gennaro , Turriziani Laura
Published: February 2024

Background:

Epilepsy is a chronic brain condition affecting over 50 million people
worldwide. Several new anti-seizure medications (ASMs) have been introduced to treat epilepsy
in recent decades.

Objective:

Nearby the specific therapeutic action, ASMs, like other types of pharmacotherapy,
can produce various side effects. In this review, we shall analyze the different pharmaceutical
classes of ASMs, their mechanism of action, and their interaction with the respiratory system.

Methods:

This manuscript is based on a retrospective review of English publications indexed by
Pubmed, UpToDate and datasheets published by the European Medicines Agency and the Food
and Drug Administration (FDA), using various terms reminiscent of ASMs and pulmonary function.

Results:

ASMs act on organism homeostasis in different ways, acting on lung function directly
and indirectly and playing a protective or damaging role. A damaging direct lung involvement
ranged from infections, hypersensitivity reactions, and respiratory depression to other structured
pulmonary diseases. Meanwhile, a damaging indirect effect, might be constituted by pulmonary
artery hypertension. On the other hand, a protective effect might be the expression of developmental
processing, decreasing airway remodelling in asthma patients, vascular remodelling in pulmonary
hypertension and, nonetheless, anti-inflammatory and immunomodulatory actions.

Conclusion:

An adequate awareness of ASMs effects on the respiratory system seems essential
for better managing frail individuals or/and those predisposed to respiratory disorders to improve
our patients' clinical outcomes.
An Insight into the Repurposing of Phytoconstituents obtained from
Delhi’s Aravalli Biodiversity Park as Antifungal Agents
Authors: Kaur Amanpreet , Sharma Kalicharan , Sharma Neetika , Aggarwal Geeta
Published: February 2024

The global prevalence of fungal infections is alarming in both the pre- and postCOVID period. Due to a limited number of antifungal drugs, there are hurdles in treatment
strategies for fungal infections due to toxic potential, drug interactions, and the development
of fungal resistance. All the antifungal targets (existing and newer) and pipeline molecules
showing promise against these targets are reviewed. The objective was to predict or repurpose
phyto-based antifungal compounds based on a dual target inhibition approach (Sterol-14-αdemethylase and HSP-90) using a case study. In pursuit of repurposing the phytochemicals as
antifungal agents, a team of researchers visited Aravalli Biodiversity Park (ABP), Delhi, India,
to collect information on available medicinal plants. From 45 plants, a total of 1149 ligands
were collected, and virtual screening was performed using Schrodinger Suite 2016 software
to get 83 hits against both the target proteins: Sterol-14-α-demethylase and HSP-90. After
analysis of docking results, ligands were selected based on their interaction against both the
target proteins and comparison with respective standard ligands (fluconazole and ganetespib).
We have selected Isocarthamidin, Quercetin and Boeravinone B based on their docking score
and binding interaction against the HSP-90 (Docking Score -9.65, -9.22 and -9.21, respectively) and 14-α-demethylase (Docking Score -9.19, -10.76 and -9.74 respectively). The docking protocol was validated and MM/GBSA studies depicted better stability of selected three
ligands (Isocarthamidin, Quercetin, Boeravinone B) complex as compared to standard complex. Further, MD simulation studies were performed using the Desmond (67) software package version 2018-4. All the findings are presented as a case study for the prediction of dual
targets for the repurposing of certain phytochemicals as antifungal agents.
A Review on Recent Patents for Oil Mist Separation Devices
Authors: Li Yunfeng , Xu Xinming , Li Ming , Li Ruoxuan , Zhang Hang , Tian Ao
Published: February 2024

:

Oil mist separation technology and oil mist separation devices are indispensable
components of modern industry and engines and are important means to improve air quality and
reduce oil mist diffusion. However, in the study of their separation efficiency and oil droplet
collection, there are still some techniques that need breakthroughs to be able to better separate oil
mist in the future.

:

Through the introduction and discussion of the patent characteristics of oil mist separation devices in
recent years, some valuable conclusions are summarized, and future research and development have
been prospected.

:

The patents of various separation devices were studied, and the patents and research prospects of oil
mist separation devices were summarized.

:

With the development of the machinery industry, oil mist separation has become more and more
important, so a separation device is required to realize the separation, collection, recycling, and
utilization of oil mist.

:

By elaborating on the structural characteristics of the separation device, the importance of the
separation device is discussed. By comparing these patents, it is concluded that electrostatic
separators and composite separation devices are the main development trends of future separation
devices.
Neuropharmacological Potential of Different Piperazine Analogs: A Recent Prospective
Authors: Almehmadi Mazen , Allahyani Mamdouh , Alsaiari Ahad Amer , Asif Mohammad , Kumar Sachin
Published: February 2024

Heterocyclic moiety is a key part of some enzymes and vitamins and plays a vital role in
various biochemical and enzymatic processes. Piperazine ring is a heterocyclic moiety present in
various well-known drugs and is effective against different types of diseases by acting on a variety
of receptors. Various piperazine analogs possess diverse biological activities, especially in central
nervous system disorders, which involve the activation of neurotransmitter receptors and targeting
various enzymes and act as antianxiety, antipsychotic, antidepressant, etc. This review is focused
on the piperazine derivatives and their diverse therapeutic potential against different types of diseases
particularly against neuronal disorders.
Potential Correlation between Gene Mutations and Metabolic Changes in
Acute Myeloid Leukemia
Authors: Jiang Aili , Hou Zhiying , Yu Bingyan , Wang Ning , Zhang Bin
Published: February 2024

Acute myeloid leukemia (AML) is a common type of leukemia. However, the understanding
of AML remains insufficient. The pathological progression of AML is closely related to chromosome
abnormalities and genetic mutations. Gene mutation is an important factor in the pathogenesis
of AML and a potential cause of drug resistance. Recent studies have shown that gene mutations in
AML can cause metabolic changes. Metabolites, as downstream products of human physiological
activities, can amplify physiological and disease-related signals. Therefore, the analysis of metabolite
markers related to gene mutations can be used for early prediction of the occurrence of the disease.
This review describes the types and significance of AML gene mutations and analyzes the characteristics
of metabolic changes related to gene mutations.
Fault Section Localization Method for Distribution Network based on Synchronous Phasor Measurement
Authors: Fu Yu , Li Yue , Xiao Xiaobing , Liu Shuo , Cai Yongxiang , Liu Hao
Published: February 2024

Background:

The accurate locating of fault sections in a distribution network can lay
an effective foundation for the rapid processing of faults. However, the waveform of highresistance
grounding faults is relatively weak, which increases the difficulty of fault feature extraction
and localization. In addition, the complex operating conditions and interference factors of
the actual distribution network can affect the fault section localization method, leading to incorrect
location problems.

Objective:

In order to overcome the limitations of existing fault section localization methods on
fault resistance values and application scenarios, a fault section localization method for distribution
networks based on synchronous phasor measurement is proposed in this paper.

Methods:

Firstly, the transient zero sequence equivalent network of single-phase to ground faults
in the distribution network is analyzed, revealing the differences in zero-sequence current within
different sections of the faulty line. At the same time, based on the zero-sequence current waveform
recorded by the waveform measurement device in actual distribution network, the characteristics
of the waveform in different sections in the time and frequency domains are analyzed. Furthermore,
a fault feature extraction method based on wavelet packet transform is proposed to construct
fault differential features for different sections. Then, the grey correlation analysis method is
adopted to calculate the correlation coefficients between different sections to construct locating
criteria, thereby achieving accurate locating of fault sections in distribution network.

Results:

The experimental results using field data indicate that the localization accuracy can reach
98.90%, and the calculation time is about 102.65 ms, which has high localization accuracy and
localization efficiency.

Conclusion:

Through analysis and relevant experiments, it is concluded that the proposed method
can accurately locate faults in actual distribution networks, and still has correct locating results for
high resistance grounding faults. The effectiveness of the method has been verified.
Fractional Trigonometric Function Approximations in a Regular System
Authors: Boucherma Djamel
Published: February 2024

Introduction:

Linear fractional differential equations of the commensurable order, specifically
those related to fractional trigonometry, pose challenges in terms of analytical solutions.

Methods:

The purpose of this article is to present a novel approximate analytical technique to
solve linear fractional differential equations of the commensurable order, which are related to
fractional trigonometry. This method is used to obtain approximate solutions by forming linear
combinations of appropriate fractional basic functions, for which Laplace transforms are irrational
functions. This approximation technique enables us to represent these functions using timeinvariant
linear system models. Also, the implementation of analog circuits of these basic fractional
order systems can be obtained using approximation of rational functions.

Results:

The research demonstrates the efficacy and precision of this method through illustrative
examples, showcasing its effectiveness in solving linear fractional systems.

Conclusion:

The newly introduced approximate analytical method presents a promising approach
to solving linear fractional differential equations of the commensurable order, providing accurate
solutions and possibly offering applications in various fields.
An Insight into Synthetic Strategies, SAR Study and Anticancer Mechanism of Chalcone Derivatives: Medicinal Chemistry Perspective
Authors: karati Dipanjan , Kumar Dileep
Published: February 2024

Chalcone derivatives continue to captivate medicinal chemists due to their modest
chemistry, facile synthetic method, and promising biological activities. They have become wellknown
in the therapeutic and pharmaceutical industries due to their diverse biological actions.
These complexes offer different features and applications in a human biological system due to
the flexibility of the reactions, including antimicrobial, antineoplastic, antimalarial, and other
uses. As a result, chalcones have sparked much attention in malignancy research. Cancer is
characterized by uncontrollably growing and spreading abnormal cells and aberrant cell behavior.
These masses destroy surrounding normal tissue and can attack vital organs, leading to
widespread disease. Cancer is frequently used as a warning sign for impending patient death. In
the age of pharmaceutical chemistry, it is unavoidably a cause for concern and a growing
weight on the populace. The pathophysiology of all malignancies is due to faulty genes that
regulate the development, division, and death of cells. Various genetic and environmental variables
combine to cause mutations in genes encoding essential cell-regulatory proteins, leading
to the numerous alterations that characterize the evolution of cancers. Rather than directly targeting
DNA synthesis, the new generation of anticancer medications target signals that promote
or control the cell cycle, growth factors and their receptors, signal transduction pathways, and
pathways impacting DNA repair and death. Drug hunters are focusing their attention on chalcone
derivatives with varying chemical structures since they are essential in the search for anticancer
drugs. Chalcone's anticancer action may be attributed to molecular changes such as drug
efflux protein activities, activation of apoptosis, DNA and mitochondrial damage, inhibition of
angiogenesis, tubulin inhibition, and kinase inhibition. Chalcones are used to diagnose cancer as
well. The development of chalcone congeners as a prodrug or prime chemical to combat cancer
necessitates a thorough investigation. This review gives an update on the different pharmacological
activities of natural and synthesized chalcones in recent years. Furthermore, the structure-
activity connections and processes are extensively documented, providing essential design
and synthesis assistance in the future.
Motion Signal-based Recognition of Human Activity from Video Stream
Dataset Using Deep Learning Approach
Authors: Yadav Ram Kumar , Arockiam Daniel , Bhaskar Semwal Vijay
Published: February 2024

Background:

Human physical activity recognition is challenging in various research
eras, such as healthcare, surveillance, senior monitoring, athletics, and rehabilitation. The use
of various sensors has attracted outstanding research attention due to the implementation of
machine learning and deep learning approaches.

Aim:

This paper proposes a unique deep learning framework based on motion signals to recognize
human activity to handle these constraints and challenges through deep learning (e.g., Enhance
CNN, LR, RF, DT, KNN, and SVM) approaches.

Method:

This research article uses the BML (Biological Motion Library) dataset gathered from
thirty volunteers with four various activities to analyze the performance metrics. It compares
the evaluated results with existing results, which are found by machine learning and deep
learning methods to identify human activity.

Result:

This framework was successfully investigated with the help of laboratory metrics with
convolutional neural networks (CNN) and achieved 89.0% accuracy compared to machine
learning methods.

Conclusion:

The novel work of this research is to increase classification accuracy with a lower
error rate and faster execution. Moreover, it introduces a novel approach to human activity
recognition in the BML dataset using the CNN with Adam optimizer approach.
Analytical and antimicrobial study of herbo-mineral formulation Shwasakasari Rasa in selected respiratory micro-organism
Authors: Neelam Malviya  , Anil Nagle  , R.K. Pati
Published: February 2024

Shwasakasari Rasa (SKR) is mentioned in Rasa Yoga Sagar,[1] (part 2) as a remedy of Shwasa & Kaasa Roga. This type of Rasa Aushadhi are more effective against bacteria. These drugs have a multi dimension effect like Broad-spectrum antibiotics. The Rasaushadies mentioned in Ayurvedic Pharmacopoeia should be analysed for physical & chemical properties to confirm purity & safety before administration in human beings. Hence it become obligatory to adopt modern analytical methodology for better understanding and interpretation of physio-chemical changes occurred during the process. SKR was analysed on the following parameter Organoleptic parameter, Physiochemical analysis, Advanced physiochemical analysis. SKR sample was tested for antimicrobial activity against standard strains of Staphylococcus aureus, Klebsiella pneumonia and Streptococcus pneumonia. The prepared Shwasakasari Rasa was studied for their MIC (Minimum Inhibitory Concentration & the zone of inhibition. The prepared drug was compared with Azithromycin (standard drug) of macrolide group to evaluate its antimicrobial efficacy. These tests was conducted in, S.R Labs & Research Centre, Jaipur.
Conceptual study on CROUP in children w.r.t. its management in Ayurvedic and Contemporary Sciences
Authors: Prajakta Palande  , Yogesh Surse
Published: February 2024

Background: Croup is a common respiratory condition in children, typically caused by a viral infection, most commonly the parainfluenza virus. It leads to inflammation and narrowing of the upper airway, primarily the trachea and larynx, which can result in distinctive symptoms like Barking cough, Stridor, hoarseness, labored breathing, Fever. Laryngotracheitis, laryngotracheobronchitis, and laryngo-tracheo-broncho-pneumonitis are all included in the spectrum of croup. Aims and Objectives: To study the etiology, progression of Croup, to study the signs & symptoms of Croup, to study the investigations and management by Ayurvedic and contemporary sciences. Materials & Methods: Authentic books and Samhitas along with the articles published is referred for the detailed information related to topic. Discussion: Diagnosis of Croup is typically diagnosed based on the child's symptoms and physical examination. In some cases, X-ray or other imaging tests is recommended. Ayurveda treats Croup in multiaspect corelating with Kasa and Shwasa Roga. Snehan by Lavangadi Taila, Swedan. Use of Kasa- Shwashara Kalpa like, Talisadi Churna, Shwaskuthar Rasa, Kanakasava. Panchakarma procedures such as Dashmool Niruha Basti, Mrudu Vaman, Virechan. Contemporary science treats it by humidified Air, corticosteroids, nebulized epinephrine, rest and Fluids. Conclusion: Croup in children is a common and usually mild respiratory condition caused by viral infections. While it can be distressing, most cases can be managed effectively at home with humidified air and, in some cases, corticosteroids. Knowing the symptoms and when to seek medical attention is crucial for parents and caregivers to ensure the well-being of their children.
Nadi Vikriti in Pranavaha Srotas diseases
Authors: Thakur Sonali  , Indu  , Sakshi  , Rupali
Published: February 2024

Ayurveda involves the practice of aligning one's life with the principles of nature. Its aims and objectives include maintaining the perfect health of a healthy person and preventing and curing diseases in an unhealthy person. Dosha, Dhatu, and Mala are the basis of diagnosing and treating any disease. Srotas are the channels of the body that carry Dosha, Dhatu, and Mala in them, which makes its examination vital. Various acharyas have given different types of diagnostic methods like Trividha Pareeksha, Dashvidha Pareeksha, Ashthvidha Pareeksha etc. The concept of Nadi Pareeksha is found under the Ashtavidha Pareeksha mentioned by Yogaratnakar. Nadi Pareeksha is an ancient technique of diagnosis through pulse. Through Nadi, we can determine Prakriti-Vikriti, disorders of Dhatus, Dosha predominance, and vitiation in various Srotas. One such Srotas is the Pranvaha Srotas, which is the channel in our body that maintains our respiration, making it essential for maintaining life and longevity. Hence it becomes crucial to successfully diagnose any vitiation or pathology of this Srotas. If used correctly by ayurvedic practitioners, Nadi Pareeksha can be a cost-effective, valuable diagnostic tool that can help access ailments at a primitive stage.
A literary review on Daivavyapashraya Chikitsa (Medical Astrology): A unique management in Ayurveda
Authors: Sapna S  , Menakshi Pachori
Published: February 2024

The holistic approach of treatment in Ayurveda includes, Yuktivyapashraya Chikitsa, Satvavajaya Chikitsa and Daivavyapashraya Chikitsa. Only the first two are in regular practice while this spiritual therapy i.e., Daivavyapashraya Chikitsa is totally ruled out in this IT world, as it is beyond the purview of reasoning. We have references of Daivavyapashraya Chikitsa in all our classical text books. Homa, Havana, Japa, Tapa, Mani, Mantra, Upavasa, Prayaschitta, Gamana are mentioned in Daivavyapashraya Chikitsa. Daiva is Atma Kruta Karma (i.e., deeds done by one’s own self). It is a philosophical Tatwa, one face for whatever is done in the past or previous Janma. In this present scenario, the chronic, serious diseases are increasing due to bad food style and wrong life style. Thus, cases of Infertility, Cancer, Alzheimer’s are also increasing. For such non-curable diseases, when planetary positions are not supportive for easy cure, using Daivavyapashraya Chikitsa can enhance the quality of life. Especially in infertility, many case study is documented after right rituals are done, couples have conceived, who had failures after trial of both Allopathy and Ayurveda therapies for infertility. So, Daivavyapashraya Chikitsa is a Indriyaateeta (not accessible to sense organs). Thus, it is kept aside by the Ayurveda fraternity and from the research in the field of science. But, it’s now the high time and right time has come to utilize this divine knowledge in guiding and helping the human kind in leading a better-quality life to be healthier and to lead a happy life.
Penilaian Kinerja Sistem Irigasi dan Angka Kebutuhan Nyata Operasi dan Pemeliharaan pada Daerah Irigasi Ampomangiran VI Kecamatan Plemahan Kabupaten Kediri
Authors: Achmad Firly Ardiansyah  , Linda Prasetyorini  , Jadfan Sidqi Fidari
Published: February 2024

: Daerah Irigasi Ampomangiran VI terletak pada Kecamatan Plemahan Kabupaten Kediri. Masih dapat ditemukan beberapa permasalahan di lapangan mulai dari bangunan irigasi hingga saluran irigasi dengan kondisi buruk yang berakibat pada kurang maksimalnya produktivitas tamam. Selain itu, banyak ditemui vegetasi liar di sekitar bangunan dan saluran irigasi yang mengganggu fungsi dari bangunan dan saluran sekitarnya. Dari hasil inventarisasi dan penilaian aset irigasi, didapatkan nilai Indeks Kinerja Sistem Irigasi pada Daerah Irigasi Ampomangiran VI sebesar 74,08%. Nilai tersebut terdiri dari 6 aspek penilaian yang diantaranya aspek prasarana fisik sebesar 27,77%, aspek produktivitas tanam sebesar 14,06%, aspek sarana penunjang sebesar 8,1%, aspek organisasi personalia sebesar 12,05%, aspek dokumentasi sebesar 4,10%, dan aspek Perkumpulan Petani Pemakai Air (P3A) sebesar 8%. Dari perhitungan nilai prioritas perbaikan yang dilakukan dengan metode Analytic Network Process (ANP) didapatkan nilai prioritas perbaikan tertinggi pada aspek bangunan utama yang berada di dalam aspek prasarana fisik. Untuk perhitungan Angka Kebutuhan Nyata Operasi dan Pemeliharaan (AKNOP) Daerah Irigasi Ampomangiran VI sebesar 233.802.137 (dibulatkan menjadi 233.803.000)
Effect of Pink Noise on Sleep Quality of College Students
Authors: Jeon Gyungsik , No Eunbi , Han Woojae
Published: February 2024

Purpose: Sleep is very important to modern people. Recently, various noises that help with sleep have been introduced. The present study attempted to analyze a positive effect of pink noise and sleep quality on college students with high stress regarding career and future employment.Methods: A total of 120 students with normal hearing were participated and randomly divided into three different pink noise types, which were sound of rain, sound of waves, and heart sound. They were asked to listen to the pink noise for an hour before going to sleep for 3 days. Korean version of Pittsburgh Sleep Quality Index (PSQI-K) was measured twice, before and after the experiment, to compare the subjects’ sleep quality after exposure to pink noise with their sleep quality in the everyday sleep environment.Results: With pink noise exposure, the PSQI-K scores were decreased from 5.94 to 2.85. In addition, there were significant differences in three sub-categories of the PSQI-K, i.e., subjective sleep quality, sleep disturbances, and daytime dysfunction with and without sleep-inducing noise. However, there was no statistically significant difference in PSQI-K scores between groups according to the three types of pink noise.Conclusion: Based on the current results, pink noise helped them sleep better although they are being exposed for a very short period. Since the current study collected data only from healthy college students, following research should be conducted to determine the effects of pink noise on sleep disorders.
Effectiveness of Telemedicine for Musculoskeletal Disorders: Umbrella Review (Preprint)
Authors: Bargeri Silvia , Castellini Greta , Vitale Jacopo Antonino , Guida Stefania , Banfi Giuseppe , Gianola Silvia , Pennestrì Federico
Published: February 2024

BACKGROUND

Several systematic reviews (SRs) assessing the use of telemedicine for musculoskeletal conditions have been published in recent years. However, the landscape of evidence on multiple clinical outcomes remains unclear.

OBJECTIVE

We aimed to summarize the available evidence from SRs on telemedicine for musculoskeletal disorders.

METHODS

We conducted an umbrella review of SRs with and without meta-analysis by searching PubMed and EMBASE up to July 25, 2022, for SRs of randomized controlled trials assessing telemedicine. We collected any kind of patient-reported outcome measures (PROMs), patient-reported experience measures (PREMs), and objective measures, including direct and indirect costs. We assessed the methodological quality with the AMSTAR 2 tool (A Measurement Tool to Assess systematic Reviews 2). Findings were reported qualitatively.

RESULTS

Overall, 35 SRs published between 2015 and 2022 were included. Most reviews (n=24, 69%) were rated as critically low quality by AMSTAR 2. The majority of reviews assessed “telerehabilitation” (n=29) in patients with osteoarthritis (n=13) using PROMs (n=142 outcomes mapped with n=60 meta-analyses). A substantive body of evidence from meta-analyses found telemedicine to be beneficial or equal in terms of PROMs compared to conventional care (n=57 meta-analyses). Meta-analyses showed no differences between groups in PREMs (n=4), while objectives measures (ie, “physical function”) were mainly in favor of telemedicine or showed no difference (9/13). All SRs showed notably lower costs for telemedicine compared to in-person visits.

CONCLUSIONS

Telemedicine can provide more accessible health care with noninferior results for various clinical outcomes in comparison with conventional care. The assessment of telemedicine is largely represented by PROMs, with some gaps for PREMs, objective measures, and costs.

CLINICALTRIAL

PROSPERO CRD42022347366; https://osf.io/pxedm/
Exploring the Perspectives of Patients Living With Lupus: Retrospective Social Listening Study (Preprint)
Authors: Spies Erica , Andreu Thomas , Hartung Matthias , Park Josephine , Kamudoni Paul
Published: February 2024

BACKGROUND

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease affecting various organs with a wide range of clinical manifestations. Cutaneous lupus erythematosus (CLE) can manifest as a feature of SLE or an independent skin ailment. Health-related quality of life (HRQoL) is frequently compromised in individuals living with lupus. Understanding patients’ perspectives when living with a disease is crucial for effectively meeting their unmet needs. Social listening is a promising new method that can provide insights into the experiences of patients living with their disease (lupus) and leverage these insights to inform drug development strategies for addressing their unmet needs.

OBJECTIVE

The objective of this study is to explore the experience of patients living with SLE and CLE, including their disease and treatment experiences, HRQoL, and unmet needs, as discussed in web-based social media platforms such as blogs and forums.

METHODS

A retrospective exploratory social listening study was conducted across 13 publicly available English-language social media platforms from October 2019 to January 2022. Data were processed using natural language processing and knowledge graph tagging technology to clean, format, anonymize, and annotate them algorithmically before feeding them to Pharos, a Semalytix proprietary data visualization and analysis platform, for further analysis. Pharos was used to generate descriptive data statistics, providing insights into the magnitude of individual patient experience variables, their differences in the magnitude of variables, and the associations between algorithmically tagged variables.

RESULTS

A total of 45,554 posts from 3834 individuals who were algorithmically identified as patients with lupus were included in this study. Among them, 1925 (authoring 5636 posts) and 106 (authoring 243 posts) patients were identified as having SLE and CLE, respectively. Patients frequently mentioned various symptoms in relation to SLE and CLE including pain, fatigue, and rashes; pain and fatigue were identified as the main drivers of HRQoL impairment. The most affected aspects of HRQoL included “mobility,” “cognitive capabilities,” “recreation and leisure,” and “sleep and rest.” Existing pharmacological interventions poorly managed the most burdensome symptoms of lupus. Conversely, nonpharmacological treatments, such as exercise and meditation, were frequently associated with HRQoL improvement.

CONCLUSIONS

Patients with lupus reported a complex interplay of symptoms and HRQoL aspects that negatively influenced one another. This study demonstrates that social listening is an effective method to gather insights into patients’ experiences, preferences, and unmet needs, which can be considered during the drug development process to develop effective therapies and improve disease management.
Microbial Profile and Antibiotic Susceptibility Pattern of Frozen Food in India
Authors: Mazhari Bi Bi Zainab , Alanazi Fehaid , Abosalif Khalid , Mohammed Ali Tagwa Salah Ahmed , Hussein Sanaa Elfaith , Agsar Dayanand
Published: February 2024

This investigation was carried out to examine the safety and microbiological quality of products made from meat, dairy and vegetables. Samples of frozen food were examined for the presence of Gram-negative bacteria. A total of 49 frozen food samples were collected, including chicken nuggets, chicken fillets, chicken sticks, breaded breast chicken, fish, beef burger and minced beef roll, white cheese, camembert cheese, and vegetables (okra and green peas). Standard methods were used to determine the diversity of bacterial isolates in various food samples. About 182 isolates of Escherichia coli, 63 isolates of Salmonella typhi, 51 isolates of Pseudomonas, and 63 isolates of Klebsiella were recovered from the various frozen food samples. Meat samples showed a high prevalence of E. coli and Pseudomonas. The antibiotic susceptibility patterns of the isolated bacterial strains were also examined. Out of 12 antibiotics, only ciprofloxacin and ofloxacin showed a high level of susceptibility. According to the study’s findings, the majority of the frozen meat product samples contained a significant number of bacteria and were therefore unsafe for human consumption. These microorganisms can cause infection and are therefore associated with a high risk to the consumers. Therefore, it is important to pay attention to health and education issues in relation to food safety.
An Insight into the Role of Phenolics in Abiotic Stress Tolerance in Plants: Current Perspective for Sustainable Environment
Authors: Ray Anuprita , Kundu Somashree , Mohapatra Shuvendu Shekhar , Sinha Somya , Khoshru Bahman , Keswani Chetan , Mitra Debasis
Published: February 2024

Phenolic compounds (PCs) are a prominent class of secondary metabolites produced by plants and are essential for the natural role of the entire plant life cycle. PCs are formed in plants under both favorable and unfavorable conditions and have essential functions in signaling pathways, such as cell division, nutrient mineralization, hormone control, and reproduction. Under abiotic stress conditions, plants produce more polyphenols, which aid them in adapting to their environment. The phenylpropanoid biosynthetic pathway is activated under various environmental stress conditions, such as drought, heavy metal toxicity, salinity, and high/low temperatures, resulting in the deposition of compounds. These compounds can neutralize reactive oxygen species (ROS) produced in excessive amounts in crops under stressful conditions and adversely affect plants. It is imperative to investigate the functions of PCs in response to several abiotic stresses, as the phenylpropanoid pathway plays a crucial role in the metabolic pathway in crop plants, leading to the biosynthesis of a wide range of PCs. These compounds play various roles in plant growth, development, and response to environmental stress. Therefore, this review provides a comprehensive understanding of PCs and their exchanges with other cellular components, which is crucial for harnessing their potential to improve crop resilience to environmental stresses.
Artificial Intelligence in Healthcare
Authors: Shaikh Saniya
Published: February 2024

Abstract: This research paper offers an in-depth examination of how artificial intelligence (AI) is utilized in the healthcare sector. The primary emphasis is on understanding the profound influence it has in areas such as disease diagnosis, personalized medicine, and the optimization of patient care.
Comparative Study of R.C.C. and Composite Structures Under Different Soil Conditions
Authors: Patidar Tushar , Maru Dr. Savita
Published: February 2024

Abstract: The need for multi-storey buildings arises from a fact that it offers vertical expansion, making them an ideal choice for maximizing available urban space without influencing valuable land resources. A thorough literature review has conducted for comparative study of RCC and Composite buildings and its various advancements conducted before. This paper is based on regular and irregular plan area under different soil conditions. Total 18 cases have taken for consideration (6- square shape, 6 – L shape and 6 – T shape plan) with 3 cases each of RCC and 3 cases for Composite building and method selected - Response Spectrum Method. Results for Square shape plan shows that SCPH case i.e. Square plan with Composite structure over hard soil performs well in most of the output parameters. Results for L shape plan shows that LCPH case i.e. L shape plan with Composite structure over hard soil performs well in most of the output parameters while in case of story displacement and drift LRCCH i.e. L shape plan with RCC structure over hard soil performs better but the values of LCPH are also within the limits of IS codes. Results for T shape plan shows that in case of story displacement and drift TRCCH i.e. T shape plan with RCC structure over hard soil performs better because of the higher stiffness of RCC structure while in all other output parameters TCPH i.e. T shape plan with composite structure over hard soil performs well. Concluding the research work, use of composite structure performs well and can be used with building stability techniques so that the displacement factors can be minimized for composite structures.
IoT Based Design and Implementation of Intelligent Energy Distribution Management with Photovoltaic System
Authors: Gundawar Bavana , Qaviuddin MD , Guguloth Lingalal , Pillamarapu Nikhil , Thipparapu Rajesh
Published: February 2024

Abstract: The grid operators have difficulties as a result of the increasing penetration of renewable sources due to reduced environmental contamination. Unrestrained energy use will undoubtedly deepen environmental harm and accelerate global warming. A best practice for effectively managing energy use is energy management. IoT technology can be leveraged by technological advancements to facilitate energy management. This paper offers a novel way to energy management using a solar system and the Internet of Things (IoT). The suggested system tracks, evaluates, and optimizes solar power use in real time with the goal of increasing energy distribution's intelligence and efficiency. The project's goal is to build a net energy meter (NEM), a unique billing system that gives solar PV system owners credit for the entire retail value of the electricity their system produces. Under NEM, a customer's electric meter tracks how much energy they use as well as how much extra energy the system produces and feeds back into the electric utility grid.
Comunidades, modo de usar: desvendando guias, manuais e relatórios da mineração
Authors: Giffoni Pinto Raquel , Mansur Maíra Sertã , Losekann Cristiana
Published: February 2024

Nos últimos vinte anos, observou-se um aumento dos conflitos ambientais relacionados às atividades de mineração em diversas partes do mundo. A fim de compreender como os agentes do setor extrativo descrevem estes conflitos e de que forma têm atuado para respondê-los, este artigo analisará dois conjuntos de publicações produzidos na última década. Os relatórios de riscos e tendências do setor extrativo elaborados pelas consultorias Ernst & Young, PricewaterhouseCoopers, Deloitte e KPMG e três manuais de relacionamento com comunidades do Instituto Brasileiro de Mineração, da Confederação Nacional da Indústria e do Conselho Internacional de Mineração e Metais. Identificamos que a produção e a circulação destes materiais integram o conjunto de práticas autoritárias das corporações extrativas em pelo menos três dimensões: i) a compreensão de que atores sociais organizados que atuam na defesa dos territórios são riscos a serem gerenciados; ii) à difusão de técnicas de “diálogo” e “participação social” utilizadas para a identificação e classificação dos atores sociais e iii) a promoção da ideia de que o destino do território está inelutavelmente ligado à corporação.
HelloFresh: Transitioning to a plastic-free future?
Authors: Sharda Nikita , Krampe Caspar , Ingenbleek Paul T.M.
Published: February 2024

The packaging practices of HelloFresh have come under scrutiny in recent years as a result of the company’s remarkable expansion success. Customers have cancelled their meal-kit subscriptions due to the excessive use of plastic packaging for ingredients. In response to these events, HelloFresh began to seek alternatives to replace plastic packaging for its ingredients, but ultimately found that the currently available packaging technology makes it impossible to eliminate plastic completely. HelloFresh is therefore looking for ways to communicate with customers about its sustainability message and their actions to be cost-effective, retain food-safety, and foster sustainability with regard to packaging while making innovative changes in its packaging processes. In the current stage of the sustainability transition for packaging materials in which no ready-at-hand solutions are available, it is crucial for HelloFresh to strike a balance between converting its packaging practices to be more sustainable and communicating this message effectively to its customers.
Seismic Image of the Central to Southern Andean Subduction Zone Through Finite-Frequency Tomography
Authors: Kondo Yuko , Obayashi Masayuki , Sugioka Hiroko , Shiobara Hajime , Ito Aki , Shinohara Masanao , Iwamori Hikaru , Kinoshita Masataka , Miller Matthew , Tassara Carlos , Ojeda Javier
Published: February 2024

This study presents new seismic imaging of the Andean subduction zone
through P-wave hybrid finite-frequency and ray-theoretical tomography.
We measured both differential and absolute traveltimes using broadband
seismic waveforms from stations in an array of ocean-bottom seismographs
near the Chile Triple Junction (CTJ) and stations within 30° from the
array. These data were combined with the global traveltime dataset to
obtain a global P-wave velocity structure with a focus on central to
southern South America. The new tomographic image showed the Nazca slab
geometry as a continuous fast anomaly, which is consistent with seismic
activity and prior slab models. Furthermore, two notable structures were
observed: a broad extension of the fast anomaly beneath the Nazca slab
at 26–35° S and a slow anomaly east of the CTJ. The checkerboard
resolution and recovery tests confirmed the reliability of these
large-scale features. The fast anomaly, isolated from the Nazca slab,
was interpreted as a relic Nazca slab segment based on its strong
amplitude and spatial coincidence with the current Pampean and past
Payenia flat slab segments. The slow anomaly near the CTJ was consistent
with the previously inferred extent of the Patagonian slab window.
Moreover, the active adakitic volcanoes are aligned with the southern
edge of the anomaly, and the plateau basalts are located within the
anomaly. Our model showed that the slow anomaly extended to a depth of
up to 250 km, suggesting a depth limit that the asthenospheric window
can influence.