bluuebunny/crossref_metadata_2025 huggingface dataset:
Ejecución presupuestaria y su desarrollo en la Gestión Pública del Instituto Ecuatoriano de Seguridad Social, Manabí
Authors: Ubillus Garcia Cristhian , Amancha Chiluisa Linda de las Mercedes
Published: December 2024

La ejecución presupuestaria en los procesos de contratación pública se evalúa mediante los indicadores del Plan Anual de Contratación. La correcta planificación, elaboración y ejecución de estos procesos es fundamental, ya que su incumplimiento ocasiona retrasos en la entrega de servicios, extensiones indebidas en los contratos y la consecuente pérdida de valores presupuestados al cierre del año fiscal. Estas falencias generan deudas arrastradas al presupuesto del siguiente año, impactando negativamente en la estabilidad económica de las instituciones. En esta investigación se analizó la ejecución presupuestaria y su impacto en la gestión pública del Instituto Ecuatoriano de Seguridad Social (IESS), Manabí, durante el año 2022. El objetivo principal fue identificar mecanismos que previnieran recortes económicos en el presupuesto del año 2023. Para ello, se adoptó un diseño metodológico cualitativo, con un enfoque explicativo-descriptivo y un carácter bibliográfico-documental. Se emplearon métodos deductivo, inductivo y normativista, complementados con entrevistas como técnica de recolección de datos. Los resultados evidenciaron que una adecuada planificación en los procesos de contratación contribuye significativamente a una ejecución presupuestaria eficiente, lo que permite optimizar el uso de los recursos y prevenir problemas financieros en ejercicios fiscales futuros. Este hallazgo subraya la importancia de fortalecer las prácticas de gestión pública a través de un enfoque estratégico y normativo en la contratación pública.
Государственные меры по снижению смертности населения Тульской области
Authors: Медведева Т.В. , Комов В.Э.
Published: December 2024

В работе проведен анализ демографической ситуации в Тульской области, обозначены причины смертности населения, факторы повышенного риска преждевременной смертности населения. Влияние социально-экономических факторов, от которых зависит смертность населения, определено через корреляционный анализ. Рассчитаны прогнозные показатели факторов, влияющих на количество умершего населения Тульской области. Произведен прогноз числа показателей, характеризующих демографическую ситуацию в Тульской области до 2028 г. Проведен SWOT-анализ государственных мер поддержки снижения смертности населения Тульской области на основе влияния внешних и внутренних факторов. Разработаны государственные меры снижения смертности Тульской области, которые позволят повысить продолжительность жизни населения в регионе.

The paper analyzes the demographic situation in the Tula region, identifies the causes of mortality, factors of increased risk of premature mortality. The influence of socio-economic factors on which mortality depends is determined through correlation analysis. The predicted indicators of factors affecting the number of deceased people in the Tula region are calculated. A forecast of the number of indicators characterizing the demographic situation in the Tula region until 2028 is made. A SWOT analysis of government measures to support the reduction of mortality in the Tula region is carried out based on the influence of external and internal factors. Government measures to reduce mortality in the Tula region are developed, which will increase life expectancy in the region.
Политика Дании в области «зеленого» водорода
Authors: Армашова-Тельник Г.С. , Рыжова А.В.
Published: December 2024

В статье рассматриваются стратегические документы Дании в сфере развития технологий, позволяющих преобразовать возобновляемую электроэнергию в другие формы энергетических продуктов (водород, метанол, аммиак). Анализируется создание нормативно-правовой базы и инструментов финансирования. Большинство датских проектов по производству «зеленого» водорода находится на ранних стадиях разработки. Их успех будет в значительной степени зависеть от поддержки государства, развития нормативно-правовой базы и создания спроса, в том числе посредством квот, топливных стандартов и правил государственных закупок. Дания отдает предпочтение электрификации и намерена применять данные технологии в секторах, где электрификация проблематична, также планируется экспорт «зеленого» водорода.

The article examines Denmark's strategic documents in the field of developing technologies that allow the conversion of renewable electricity into other forms of energy products (hydrogen, methanol, ammonia). The creation of a regulatory framework and financing instruments is analyzed. Most Danish green hydrogen projects are in the early stages of development. Their success will depend largely on government support, development of the regulatory framework and demand creation, including through quotas, fuel standards and public procurement rules. Denmark prioritises electrification and intends to apply these technologies in sectors where electrification is problematic, and plans to export green hydrogen.
Стартап как инновационная компания: специфика и эволюция методологических подходов (на примере Франции)
Authors: Черноуцан Е.М.
Published: December 2024

Статья посвящена анализу специфики и эволюции понятийного аппарата стартап компаний в условиях современной Франции. В центре внимания — методологические подходы к определению понятия стартапов, оригинальность которых во многом диктуется централизованным характером ее государственного устройства и управления. Автор попытался показать многообразие официально принятых определений, новых терминов и классификаций, отражающих требования французской экосистемы стартапов в новых условиях стремительных технологических изменений. Особое внимание было уделено высокотехнологичным стартапам, которые начинают рассматриваться правительством Франции как важнейший инструмент инновационной реиндустриализации страны. Были изучены новые официальные определения для стартапов в области прорывных и глубоких технологий («start-ap DeepTech», «start-up GreenTech» и др.), а также специальное ранжирование для перспективных стартапов (Next40 и French Tech 120), способных стать лидерами международного уровня.

The article is devoted to the analysis of the specifics and evolution of the conceptual apparatus of startup companies in the context of modern France. The focus is on methodological approaches to defining the concept of startups, the originality of which is largely dictated by the centralized nature of its state structure and management. The author has attempted to show the diversity of officially accepted definitions, new terms and classifications reflecting the requirements of the French startup ecosystem in the new conditions of rapid technological change. Particular attention was paid to high-tech start-ups, which are beginning to be considered by the French government as the most important tool for the country's innovative reindustrialization. New official definitions for startups in the field of disruptive and deep technologies (“start-up DeepTech”, “start-up GreenTech”, etc.) were studied, as well as a special ranking for promising startups (Next40 and French Tech 120) capable of becoming international leaders.
Концепция стоимостной оценки бизнеса с использованием технологии искусственного интеллекта
Authors: Помулев А.А.
Published: December 2024

В условиях стремительного развития технологий искусственного интеллекта необходимо трансформировать инструментарий стоимостной оценки. В статье анализируются недостатки, характерные для существующих подходов и методов оценки стоимости бизнеса, состоящие в низкой точности прогнозирования, субъективности экспертных оценок, ограниченности учета внешних факторов. Также отмечается сложность обработки больших объемов данных и недостаточная адаптивность традиционных методов к быстро меняющимся условиям современной экономики. Рассмотрены основные разделы искусственного интеллекта (поверхностное и глубокое машинное обучение и его основные подразделы) и их применимость с целью устранения недостатков методического инструментария стоимостной оценки бизнеса. Определена базовая концепция оценки стоимости бизнеса с использованием искусственного интеллекта, которая заключается в отдельных принципах, методах работы с показателями стоимости, с применением подходов к исследовательскому анализу данных, математических алгоритмах машинного обучения. Целевой процесс стоимостной оценки должен строиться на основе мультифункциональной диалоговой системы, на основе большой языковой модели (LLM) и ансамбля расчетных моделей, реализующих модернизированные подходы и новый синтетический подход. Статья будет полезна практикующим специалистам в области оценки стоимости бизнеса.

In the context of the rapid development of artificial intelligence technologies, it is necessary to transform the tools of valuation. The article analyzes the shortcomings characteristic of the existing approaches and methods of assessing the value of business, consisting in the low accuracy of forecasting, the subjectivity of expert assessments, and the limited consideration of external factors. It also notes the complexity of processing large amounts of data and the lack of adaptability of traditional methods to the rapidly changing conditions of the modern economy. The main sections of artificial intelligence (surface and deep machine learning and its main subsections) and their applicability in order to eliminate the shortcomings of the methodological tools for business valuation are considered. The basic concept of business valuation using artificial intelligence is determined, which consists in certain principles, methods of working with value indicators, using approaches to research data analysis, mathematical algorithms of machine learning. The target process of valuation should be based on a multifunctional dialogue system, on the basis of a large language model (LLM) and an ensemble of calculation models that implement modernized approaches and a new synthetic approach. The article will be useful to practitioners in the field of business valuation.
EVALUATING THE EFFECTIVENESS OF KAMPUS MENGAJAR PROGRAM IN ENHANCING INDONESIAN’S LITERACY AND NUMERACY
Authors: Pujiani Tri , Sukmawati Ida Dian
Published: December 2024

This study appraises the effectiveness of the Kampus Mengajar Program on improving Indonesian primary school students' competencies in literacy and numeracy. These recent evaluations show that deficiencies of competency in those two basic skills are highly alarming and call for comprehensive educational intervention. The present study will also examine the impact of the program, from the point of view of the interns, teachers, and school administrators, on how the program serves to enhance learning outcomes for the students and professional development for the interns. A mixed-methods methodology was applied, with quantitative data obtained from pre- and post-tests, complemented by semi-structured interviews for qualitative insights. In the results, the average points increase in literacy was 10.7 and numeracy 13.5. While this can be demonstrated by statistical measurements, positive qualitative feedback regarding the efficacy of teaching and collaboration substantiates these findings. Simultaneously, several difficulties remain unresolved; the majority are to the interns' preparation and alignment with the curriculum's requirements. Overall, interns felt confident in their roles, while teachers had concerns about their preparedness. The study, therefore, concluded that Kampus Mengajar Program has been highly effective for the students in enhancing their skills but at the same time pointed out the need to enhance training and support for interns. Policies should, therefore, focus on scaling up successful components of this program to ensure the interns become ready to handle the demands placed by the curriculum. These are gaps that will have to be filled if the improvements in literacy and numeracy are to be sustained across Indonesian education.
Mısırlı Türkolog Hüseyin Mucib El-Mısrî’nin Veda Akşamı İsimli Türkçe Şiiri
Authors: Kalyon Abuzer
Published: December 2024

Orta Doğu’nun üzerinde en fazla konuşulup değerlendirmelerde bulunulan ülkelerinden birisi de hiç şüphesiz Mısır’dır. Binlerce yıllık tarihi bir devlet geleneğine sahip olan Mısır, doğal ve tarihi mirasıyla da dünya turizminin dikkatini çekmeye devam etmektedir. Başta piramitler olmak üzere ülkede Firavun devri medeniyetiyle alakalı varlıkların sırları günümüzde bile çözülmüş değildir. Osmanlı ve Türkiye bağlamında da Mısır, gözardı edilemeyecek bir ehemmiyete sahiptir. Mısır’ın Türk edebiyatı açısından en önemli özelliklerinden birisi, İstiklal Marşı şairi Mehmet Akif Ersoy’un gönüllü sürgün senelerini (11 yıl) Mısır’ın başkenti Kahire’de geçirmiş olmasıdır. Bunun dışında Mısır’da Türkçe eserler kaleme alan şahsiyetlerin sayısı da azımsanamayacak ölçüdedir. İşte bu şahsiyetlerden birisi de Mısırlı Türkolog Hüseyin Mucib el-Mısrî’dir. Hüseyin Mısrî, akademik çalışmalarının yanı sıra Türkçe şiirler de kaleme alarak şiirlerini Solgun Bir Gül ismiyle yayımlamıştır. Türk olmayan, Türkçeyi daha sonra öğrenip Türk dili ve edebiyatını akademik meslek olarak seçen birisinin Türkçe şiirler yazması dikkate değer bir hususiyet taşımaktadır. Bu çalışmada Mısır’da gelişen Türk kültür ve edebiyatı ile Mısır’ın kültürel anlamda dikkat çeken bazı şahsiyetlerine kısaca değinilecek ve Hüseyin Mucib el-Mısrî’nin Arap harfli olarak yayımladığı “Solgun Bir Gül” isimli şiir kitabında yer alan Veda Akşamı isimli şiiri Latin harflerine aktarılarak verilecektir.
Energy transition and bioeconomy: an integrated review of interconnected pathways to sustainable development
Authors: Aguiar Willian Moura de , Nascimento Marilza Neves do , Vasconcelos Rodrigo Nogueira , Rocha Washington de Jesus Sant'Anna da Franca , Jesus Taise Bomfim de , Souza Deorgia Tayane Mendes de , Pérez Taimy Cantillo , Santana Carolina Oliveira de , Alves Carine Tondo , Oliveira Otanéa Brito de , Mania Edrian , Santana Mariana Martins Medeiros de
Published: December 2024

This review examines the pivotal interaction between the energy transition and the bioeconomy, underscoring their pivotal role in mitigating climate change, resource limitations, and socioeconomic disparities. The study aims to map the evolution of ETBE research, identifying key themes, regions, and scholarly contributions driving progress in these fields. Using a bibliometric and systematic elements review approach, the study analyzes trends, collaborations, and thematic clusters from 2000 to 2023. The findings reveal exponential growth in ETBE research, with distinct thematic focuses on policy, technology, socio-economic impacts, and sustainability. Four major thematic clusters are identified: policy and economy, societal and environmental implications of energy transitions, energy systems and technologies, market dynamics, and strategic planning. The analysis underscores the global collaboration between leading nations like the United States, China, and Germany, which play pivotal roles in advancing ETBE research and innovation. While energy transition dominates the discourse, the integration with bioeconomy still needs to be explored, accounting for only 14% of the reviewed studies. This highlights the need for greater synergy between renewable energy technologies and bio-based solutions to achieve holistic sustainability goals. The review concludes that fostering inclusive collaborations, prioritizing equity, and aligning renewable energy with bioeconomic strategies are essential for achieving a low-carbon, sustainable future. The study provides a roadmap for future research and policy, emphasizing the critical importance of interdisciplinary and international efforts in shaping the global energy transition and bioeconomy landscape.
Diretiva Antecipada de Vontade em pacientes idosos com síndrome demencial: um exemplo de autonomia
Authors: Araújo Pedro Henrique Nunes de , Melo Catharina Machado Bandeira de , Septimio Josie Anne Vasconcelos , Martins Marcelo Henrique de Sousa e Silva , Ferreira Ana Claudia da Cunha
Published: December 2024

A demência é uma síndrome clínica de evolução lenta, crônica e progressiva. Esse quadro representa um desafio ao paciente, devido ao declínio cognitivo e alterações de comportamento que interferem na funcionalidade e realização de atividades diárias; e aos cuidadores, devido sobrecarga física e mental relacionada ao cuidado. Dessa forma, a elaboração da Diretiva Antecipada de Vontade (DAV) torna-se ferramenta fundamental para autonomia do idoso, no que diz respeito às decisões sobre cuidado e intervenção, para o momento em que o paciente seja incapaz de tomar decisões. Objetivos: Relatar o caso de um paciente idoso com quadro demencial, visando demonstrar a importância do acompanhamento médico para avaliação progressiva do estado mental, acolhimento familiar e abordagem de elaboração de DAV. Relato: Trata-se de paciente do sexo masculino, 70 anos, portador de hipertensão arterial sistêmica, diabetes mellitus e dislipidemia, angioplastia prévia e colocação de marca-passo. Cerca de 6 meses após abordagens cardíacas, evoluiu com tristeza, anedonia, alteração de memória e diminuição de fala. Havia iniciado tratamento psiquiátrico, sem melhora, com evolução progressiva dos sintomas. Com acompanhamento em ambulatório de Psicogeriatria, foi iniciado Donepezila, com estabilidade do quadro cognitivo. Em múltiplas consultas, abordado sobre a possibilidade de elaboração de DAV. Até o momento, paciente ainda não optou por sua realização. Conclusão: A síndrome demencial representa um desafio para os pacientes e suas famílias, o que torna o acolhimento essencial. Deve haver abordagem sobre quadro progressivo e discussão de cuidados paliativos, possibilitando autonomia do paciente.
Percepção dos técnicos de enfermagem acerca da assistência humanizada no parto
Authors: Cavalheiro Mariana Digieri , Vieira Bruna Alves de Jesus , Serra Rodrigo Aranda , Magalhães Jéssica Priscilla Resende , Ferreira Rafhaela de Moura
Published: December 2024

Considerando o cenário obstétrico, encontram-se os técnicos de enfermagem, que orientam e estão presentes durante todo o trabalho de parto e parto, mas que muitas vezes não conseguem ser ouvidos, então objetiva-se neste estudo analisar e refletir acerca da utilização das práticas humanizadas no parto e trabalho de parto, por técnicos de enfermagem. Para tanto, procede-se à um estudo de caráter qualitativo, descritivo e analítico. Na primeira parte do instrumento foram coletadas as características sóciodemográficas dos sujeitos e na etapa seguinte, os discursos foram obtidos, utilizando-se do referencial metodológico Discurso do Sujeito Coletivo. Desse modo, observa-se que que no atual cenário obstétrico, ainda envolvido por diversas formas de violência, encontra-se a enfermagem obstétrica, que tem se destacado pela comprovação de sua assistência benéfica. Esse importante papel foi destacado; além de apontarem as dificuldades encontradas na vivencia diária da assistência. O que permite concluir que faz-se necessário que toda a equipe de enfermagem reflita sobre essa importante prática e do seu real papel no processo, para que haja mudanças. É ressaltada a importância da Educação Permanente em Saúde; sugere-se também adoção da Cogestão, onde trabalhadores são sujeitos ativos e participativos no processo da saúde.
Seleção de pacientes com malformação arteriovenosa elegíveis para tratamento cirúrgico: uma revisão de literatura
Authors: Luize Léo Morato , Matusin Brenda Santana , Rodrigues Raisa Alves , Neves Maria Clara Monari , Lousa Felipe Congro , Santos Vinicius Alves dos , Costa Igor Fernando , Oliveira João Vinicius de , Rufino Isabelly Menegueli , Ribeiro Helena Vergueiro de Moraes , Andrade Larissa Vianna Fernandes de , Renzo Beatriz Bauer , Vaccaro Valentina Skzypek , Barbosa Giovanna Freitas , Junior José Sadao Koshiyama
Published: December 2024

Considerando a complexidade das Malformações Arteriovenosas (MAVs) e os riscos associados a seu tratamento, é crucial abordar a seleção adequada de pacientes para intervenções cirúrgicas. A má formação vascular pode resultar em sérios problemas clínicos, como hemorragias e convulsões, o que justifica buscar por métodos eficazes de avaliação. Objetiva-se, assim, analisar o conhecimento existente e as propostas de novos métodos para a elegibilidade de pacientes a tratamento cirúrgico, visando otimizar os desfechos e minimizar riscos. Para tanto, procede-se a uma revisão da literatura, com a coleta e análise de artigos científicos disponíveis na base de dados PUBMED, utilizando descritores específicos que garantem a relevância do material. Desse modo, observa-se que a cirurgia é considerada o padrão ouro devido à sua alta taxa de cura e baixa incidência de complicações. No entanto, a escolha do tratamento depende de escalas de risco, como a Spetzler Martin, que, embora amplamente utilizada, apresenta limitações em sua simplicidade e abrangência. Recentemente, propostas de novos critérios têm surgido, incorporando fatores adicionais, como a arquitetura da MAV e características específicas do paciente. Assim, a pesquisa revela um consenso sobre a eficácia da cirurgia, mas também destaca a complexidade do tratamento e a necessidade de uma abordagem cuidadosa e especializada. Isso envolve considerar fatores clínicos e morfológicos para decisões informadas. Conclui-se que a evolução nas escalas de seleção é fundamental para otimizar os desfechos cirúrgicos e minimizar os riscos associados, reforçando a importância de realizar esses procedimentos em centros altamente especializados.
Revisão sistemática: análise de estudos de comparação entre a dieta cetogênica e a contagem de carboidratos em pacientes com diabetes tipo I
Authors: Morais Letícia Helena Teixeira , Silva Augusto Teixeira , Viana Bruna Belo Moreira
Published: December 2024

Referencial Teórico: O Diabetes Mellitus tipo I é uma doença que afeta as células beta no pâncreas, inibindo a síntese de insulina. Tendo em mente os graves danos sistêmicos, variadas intervenções são sugeridas, tais como a dieta cetogênica, que limita rigorosamente a quantidade de carboidratos, e a contagem de carboidratos, que possibilita liberdade na alimentação por meio da aplicação de inúmeras injeções. Objetivo: Comparar os tratamentos de Diabetes Mellitus Tipo I por dieta cetogênica e contagem de carboidratos em estudos científicos na literatura. Metodologia: Foi realizada uma revisão sistemática a fim de analisar ensaios clínicos que comparam dois tratamentos para o Diabetes Mellitus Tipo I: a dieta cetogênica e a contagem de carboidratos.
Insuficiência cardíaca com fração de ejeção preservada: desafios no diagnóstico e avanços terapêuticos baseados em evidências
Authors: Figueiredo Lucas Barreto Silva , Elias Felipe Rocha , Fassi Gabriel Pozza , Freitas Guilherme Vasconcelos de , Terreiro Luiz Rodrigues
Published: December 2024

A insuficiência cardíaca com fração de ejeção preservada (ICFEP) é uma condição desafiadora que tem se tornado uma prioridade crescente na medicina cardiovascular, devido à sua prevalência em populações idosas e à complexidade de seu diagnóstico e manejo. Este artigo discute os avanços terapêuticos e estratégias de manejo baseadas em evidências para a ICFEP, com foco nas intervenções farmacológicas mais recentes e em abordagens não farmacológicas. Nos últimos anos, os inibidores de SGLT2 e os antagonistas do receptor de mineralocorticóides emergiram como tratamentos promissores, demonstrando benefícios em termos de redução de hospitalizações e melhora da qualidade de vida dos pacientes com ICFEP. Esses medicamentos têm sido eficazes não apenas em pacientes com diabetes, mas também naqueles sem comorbidades, ampliando seu uso em uma população mais ampla. Além das terapias farmacológicas, a reabilitação cardiovascular, especialmente com a prática de exercícios físicos de alta intensidade, mostrou-se eficaz na melhoria da capacidade funcional dos pacientes. Programas de treinamento físico, aliados a estratégias para o controle de comorbidades, desempenham um papel crucial no manejo da doença, melhorando os desfechos clínicos e reduzindo a mortalidade. No entanto, o tratamento da ICFEP ainda enfrenta desafios significativos, incluindo a falta de terapias direcionadas para disfunções diastólicas e a necessidade de estratégias para a remodelação cardíaca e fibrose. O futuro do manejo da ICFEP depende da pesquisa contínua, buscando novas terapias e abordagens personalizadas. Em conclusão, os avanços recentes nas intervenções farmacológicas e não farmacológicas oferecem uma visão promissora, mas mais estudos são necessários para refinar o tratamento e melhorar os prognósticos dos pacientes com ICFEP.
Condrossarcoma na sínfise púbica simulando massa pélvica: relato de caso
Authors: Peixoto Bruno Duarte , Magalhães Lúcia Cunha , Souza Bianca Carla Azevedo de , Viana Thais Brito , Lima Isabella Torres de , Brandão Marcella Nascimento , Araujo Marcelo Antonio Nobrega
Published: December 2024

Condrossarcoma é um tumor maligno produtor de matriz cartilaginosa e representa o terceiro tumor primário ósseo mais comum, ocorrendo predominantemente em ossos longos entre a quarta e quinta década de vida. A grande maioria (90%) dos casos de condrossarcoma faz parte do grupo central, que surge da cavidade medular, sendo subdivididos histologicamente em grupo convencional, mesenquimal e desdiferenciado. O estudo relata um caso de  condrossarcoma identificado em paciente com queixas urinárias, onde são frequentemente lesões grandes na avaliação inicial devido ao atraso no início dos sintomas, apresentando-se de forma inespecífica e com poucas alterações a radiografia convencional devido à anatomia complexa da pelve, e descrevendo seus aspectos de imagem também na Tomografia Computadorizada, Ultrassonografia, Ressonância Magnética, e características anatomopatológicas. O tratamento cirúrgico se apresenta como a principal ferramenta terapêutica, visto que a radioterapia e quimioterapia não demonstraram eficácia adequada.
Uso do Osimertinib 160 mg para tratamento de CPNPC: relato de caso
Authors: Pacheco Pedro Espinhosa , Bini João Antonio Piffer
Published: December 2024

Introdução: O câncer de pulmão é o câncer mais prevalente no mundo, sendo também o câncer de maior mortalidade. O câncer de pulmão de não pequenas células (CPNPC) é responsável por 85% dos casos, e está relacionada com metástases ósseas, no sistema nervoso central (SNC), e fígado. Sabe-se que boa parte das mutações envolvidas no desenvolvimento de CPNPC é a mutação no gene do receptor do fator de crescimento epidérmico (EGFR), levando a produção do EGFR com ativação permanente, e assim, gerando um descontrole sobre as vias de crescimento celular. Dessa forma, foram desenvolvidos fármacos capazes de bloquear o receptor EGFR mutado e reverter a ativação constitutiva do receptor. Atualmente, os fármacos disponíveis com esta capacidade são os inibidores de tirosina-cinase (TKIs), entre eles o osimertinib (TKI de terceira geração), que possui a capacidade de ação em mutações EGFR T790M, e penetração sobre a barreira hematoencefálica, permitindo o tratamento de metástases leptomeníngeas e encefálicas. Atualmente, o osimertinib é usado em doses de 80mg para o tratamento de CPNPC com metástase em SNC resistentes à TKIs de primeira e segunda gerações, havendo poucos estudos sobre efeitos terapêuticos e colaterais em maiores doses. Dessa forma, o presente relato de caso busca elucidar os efeitos causados pelo Osimertinib 160mg sobre o CPNPC associada a metástase meníngea e compreender os efeitos colaterais observados com o aumento da dose do medicamento. Relato de caso: Paciente do sexo feminino, 53 anos, diagnosticada em 2018 com CPNPC com mutação em EGFR e metástase meníngea. Fez uso do Osimertinib 80 mg, com estacionamento do crescimento tumoral em pulmão e meninge. Em 2020, a dose foi aumentada para 160 mg após desenvolver síndrome meníngea e observar presença de células tumorais em líquor. A paciente desenvolveu reações adversas à medicação e ao aumento de dose. Apresentou piora clínica no final de 2021, evoluindo a óbito em 2022. Conclusão: O Osimertinib 160mg apresenta alta eficácia para o controle de neoplasias e metástases com mutações em EGFR, e efeitos colaterais mais intensos que em dose habitual, sendo necessários demais estudos para compreender a eficácia do medicamento em metástases meníngeas ao longo prazo.
Formulation and evaluation of anti-arthritic potential of ointment based on flavonoids and tannins of Aristolochia longa against induced arthritis model in Wistar rats
Authors: Soumia Attou , Hamza Belkhodja , Fatima Lahcene , Mabrouk Slimani Khaled , Houari Hemida , Boumediene Meddah , Aicha Meddah Tir Touil
Published: December 2024

Aristolochia longa, belonging to the Aristolochiaceae family, helps treatvarious diseases such as cancer, abdominal pain and upper respiratory tract infections. The present work aims to assess the anti-inflammatory activity of ointments based on the flavonoids and tannins of Aristolochia longa. The acute dermal toxicity has been evaluated using Wistar rats. Then, the formulated ointments were considered for physicochemical parameters and microbiological analysis. The stability study was conducted at 4°C, 25°C and 37°C during 28 days. However, the skin tolerance test of ointments was performed by measuring the primary irritation index. In vivo, the anti-arthritic potential of the formulations was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis method. The degree of inflammation and anti-arthritic effects were assessed by radiological and histological analysis of knee joints. The results revealed that the Lethal dose 50 (LD50) was more significant than 5000 mg/kg. The microbiological and physicochemical parameters of formulations were found to be satisfactory.The stability testshowed a stable homogenous appearance, and no pathogens were revealed. At the same time, the microbial parameters were discarded on the 28th day of exposure. The skin irritant effect indicated that the prepared formulations were safe. The radiological profile and histological analysis showed an anti-inflammatory effect in the treated group by F1 and F2 formulations, reducing infiltration cellular, pannus formation and bone erosion. Leaves and roots of A. longa can be used as plant remedies for Rheumatoid arthritis and inflammatory diseases.
Mor Dijital Uygulamalar
Authors: Hanikoğlu Melike , Akman Çiğdem
Published: December 2024

Dünya’da ve Türkiye’de, kadınların daha iyi bir yaşam sürmesi ve güvende hissetmesi adına çeşitli dijital uygulamalar başlatılmıştır. Kadınlara yönelik dijital uygulamaların sayısı her geçen gün artmakta ve kullanımı yaygınlaşmaktadır. Bu uygulamalar çoğunlukla kadına yönelik şiddetin önlenmesi, kadın istihdamının arttırılması gibi önemli amaçlar doğrultusunda oluşturulmaktadır. Kadınlara yönelik dijital uygulamalar, istihdam sağlamaya yönelik dijital eğitimler, şiddet önleyici kılavuzlar, buton uygulamaları, sms yardımı gibi yarar sağlayıcı metotlar ile hızlı ve etkin bir şekilde yayılmaktadır. Dünya’da, Wosapp, Spark Women, Chilla, bsafe gibi dijital uygulamalar ön plana çıkarken; Türkiye’de, Kadın Destek Uygulaması (KADES), Mor Haritam, AMBER, Kırmızı Işık ve Kızcode gibi mobil dijital uygulamalar ön plana çıkmaktadır. Bu doğrultuda çalışmada kadınlara yönelik şiddetin önlemesi amacıyla geliştirilen mobil uygulamalar “mor dijital uygulamalar” şeklinde adlandırılarak ele alınmış ve ayrıntılı olarak incelenmiştir. Çalışma neticesinde mor dijital uygulamaların kadınların kendilerini güvende hissetmeleri adına önemli ve geliştirilmesi gereken bir adım olduğu görülmüştür.
ضمانات تنفيذ احكام القضاء الادارى فى مواجهة الادارة
Authors: عمر مهدي حمدي  , رجب محمد ندا
Published: December 2024

تتمثل ضمانات تنفيذ الأحكام القضائية فى الحالات التي ترفض فيها الجهات الإدارية تنفيذ احكام المحاكم الإدارية، الرفض الصريح أو الناقص للحكم، والغش أو عدم التنفيذ الدقيق للحكم، وعرقلة تنفيذ الحكم بقرارات إدارية فردية أو تشريعات صادرة. والمشكلة الرئيسية تتمثل في أن ضمانات تنفيذ الأحكام القضائية الصادرة عن محاكم القضاء الإداري المصرية غير كافية، حيث أن الضمانات التقليدية القائمة لا تزال غير كافية، بالإضافة إلى أن مدى التزام السلطات الإدارية بتنفيذ القرارات غير كاف. والغرض الرئيسي من الدراسة هو بيان ضمانات تنفيذ الأحكام الإدارية, من خلال بيان مدى تأثيره في عدم تحقيق الغرض المطلوب لإصدار الحكم القضائي, فضلا عن ضرورة حث المشرع المصري على اعتماد الضمانات الحديثة المتمثلة في إصدار الأوامر القضائية للسلطة التنفيذية والتهديد بالغرامات المستخدمة في القانون الفرنسي. هذا وقد تم تقسيم الدراسة إلي مبحثين, تطرقنا في المبحث الأول إلي بيان الحالات التى تمتنع فيها الإدارة عن تنفيذ أحكام المحاكم الإدارية, وذلك من خلال توضيح حالات امتناع الإدارة عن تنفيذ أحكام المحاكم الإدارية في المطلب الأول, ثم بيان مدي سلطة القاضي الإداري في توجيه أوامر للإدارة العامة كمطلب ثاني, وفي المبحث الثاني تطرقنا إلي وسائل جبر الإدارة على تنفيذ تنفيذ أحكام المحاكم الإدارية كضمانة للمتقاضي في كل من فرنسا ومصر في مطلبين. وقد توصلت تلك الدراسة إلي أن الغرامة التهديدية هي وسيلة أكراه أو إجبار مشروعة على المدين بهدف تنفيذ التزامه, فضلا عن أن المشرع القانوني الفرنسي قد خالف النظام القانوني المصري بشأن عدم تجريم الامتناع عن تنفيذ الأحكام القضائية.
Redacción I en disco compacto
Authors: Margarit Ana Maria
Published: December 2024

Este artículo trata sobre la experiencia del diseño didáctico ytecnológico de “Redacción I”, material multimedia en formatoCDRom para el cursado de la materia homónima, en su dobleoferta, presencial y a distancia, editado por el Centro de Producción,Area de Desarrollo Multimedia de la Escuela de ComunicaciónSocial, en abril de 2001.La experiencia está incluida en el proyecto PID “Enseñanza deRedacción a distancia”, reacreditado en el corriente año.Si en 1998, hicimos nuestra experiencia iniciática con el diseñoy aplicación en modalidad a distancia de una unidad de trabajo,en soporte papel, breve, modesta, puesta en uso con pocos participantesy obtuvimos resultados más que esperanzadores; si en1999, redoblamos la apuesta al diseño del segmento curricularmás importante del programa y nos involucramos en la interaccióntoda la cátedra del taller y más de 200 alumnos, esta vezcon resultados óptimos para la calidad del diseño y relativamentebuenos para la puesta con los alumnos, en el 2000 seguimosese mismo recorrido aunque dando un salto tecnológico que vadesde el papel impreso al diseño multimedia en formato discocompacto y superando las experiencias de diseño didáctico sobreuna porción de la asignatura para marchar hacia un material totalizadory completo de la currícula de Redacción Uno.
Genealogías de Walsh
Authors: Retamoso Roberto
Published: December 2024

En su lento pero sostenido tránsito hacia su canonización literaria, Operación Masacre, de Rodolfo Walsh, ha ido generando un notable y a la vez dificultoso proceso de reconocimiento, que en ocasiones puede conducir, inclusive, a una suerte de cristalización de los sentidos de un texto caracterizado por suvocación crítica y transgresiva. La parábola que dibuja ese proceso se abre con una serie de artículosperiodísticos referidos a los fusilamientos de José León Suárez publicados entre fines de 1956 y mediados de1957, y se cierra -por ahora- con la inclusión de Operación Masacre en la colección de clásicos argentinos editada por el diario Clarín y dirigida por Ricardo Piglia durante el primer año del siglo XXI.
Editorial
Authors: Reviglio Maria Cecilia , Maestri Mariana
Published: December 2024

Como dijimos desde el primer volumen de este año, en 2024 la escuela de Comunicación Social en cuyo seno nació La trama dela Comunicación cumple 50 años y nos vestimos de fiesta. Aun en este tiempo arduo para quienes habitamos el suelo argentino y,en particular, para la universidad, celebrar medio siglo de vida se vuelve un imperativo ético y político, el que nos empuja a poner derelieve el trabajo cotidiano, el de ayer y el de hoy, que nos ha hecho quienes somos.
Tramas del vínculo entre comunicación y género en la Licenciatura en Comunicación Social de UNR
Authors: Camusso Mariangeles , Figueroa Lucía Anahí , Rovetto Florencia
Published: December 2024

Hasta hace muy poco tiempo, el vínculo entre estudios de género y feminismo y estudios de la comunicación permaneció almargen de la academia donde nos formamos como profesionales de la comunicación social. Antes de la primera década del sigloXXI, quienes nos interesamos por los estudios feministas de la comunicación llegamos a un conjunto muy vasto de produccionesque se encontraban al margen del canon local a partir de la curiosidad investigativa, los vínculos internacionales o el activismoy la militancia. Aunque esta realidad es común a todas las carreras de comunicación social de nuestro país, nos interesaparticularmente en este artículo, reconstruir el modo en que los estudios de género comenzaron a hacerse lugar en la historia dela Licenciatura en Comunicación Social.
STRATEGI KOMUNIKASI PEMERINTAH DAERAH LOMBOK UTARA DALAM MEMBANGUN HUBUNGAN MASYARAKAT YANG KUAT (ANALISIS TEORI BUDAYA KUAT TERENCE DEAL DAN ALLAN)
Authors: ARISANDY RITA , PUTRA SANDI JUSTITIA , HUSBUYANTI IRMA EL-MIRA , MANDINI DENDA DEVI SARAH MANDINI , NINGRUM ANISA PURWA , MARIASEH NI WAYAN
Published: December 2024

Governments that have good relations with society tend to gain higher trust from their citizens. This trust is important for government legitimacy, which in turn increases compliance and support for government policies and programs. It is hoped that this research can help the North Lombok Regency Regional Government in developing an effective communication strategy that can be implemented in building strong community relations. Using the strong cultural theoretical framework of Terence Deal and Allan Kennedy. This research uses a qualitative approach with a literature study method. The data used comes from previous research, literature studies, and is relevant. By implementing strong cultural elements in its communications strategy, the North Lombok Regency Regional Government can build stronger relationships with the community, thereby increasing trust, participation and support for government programs. By instilling core values, elevating local heroes, holding rituals and ceremonies, utilizing informal networks, and building a strong narrative, the North Lombok Regency Regional Government can increase community trust and support. By integrating these elements, the North Lombok Regency Regional Government can create an environment that supports effective communication and builds stronger trust with the community. This will contribute to increased public participation and support for government programs, thereby bringing greater benefits to local communities
Kartepe’ye Özgü Yöresel Yiyeceklerin Envanterinin Çıkarılması: Örnek Afiş Tasarımı
Authors: Kahveci Betül , Akdemir Nihan
Published: December 2024

Yöresel yiyecekler özgünlük arayışında olan tüketiciler için, çevredeki insanlarla ve mekanlarla daha doygun bir etkileşimde olmanın yanı sıra daha özgün bir benlik duygusu elde etmeye de olanak sunmaktadır. Tanıtım ve markalaşma stratejilerinde özgünlüğü ve yerel kimliği vurgulamak, örneğin; etiketteki menşeinin yerini listelemenin yiyecek ve turizm arasındaki ilişkilerin yerel ekonomik kalkınma stratejisine adapte olabilmesi için oldukça önemlidir. Bu araştırmanın amacı; Kocaeli Kartepe bölgesinin yöresel yiyeceklerinin envanterin çıkarılması ve standart reçeteler oluşturularak tanıtım için afiş hazırlanmasıdır. Çalışmada nitel araştırma yöntemlerinden doküman analizi, içerik analizi ve derinlemesine görüşme yapılmıştır. Çalışmanın saha araştırması 28 yiyecek-içecek işletmesinin menüleri incelenmiş ve 19 katılımcıdan toplanan veriler MAXQDA programı ile analiz edilmiştir. Araştırma sonucunda Kartepe’deki yiyecek-içecek işletmelerinin %92,85’inin menülerinde yöresel yiyeceklere yer verdiği ile Kartepe’ye özgü yöresel yiyeceklerin en fazla bilinir olanlarının “kara lahana”, “yufka böreği” ve “tarhana” olduğu belirlenmiştir.
Öğrenme ve Bellek Deneylerinde Deney Hayvanlarına Yaklaşım ve Deney Modellerinin Değerlendirilmesi
Authors: Altunkaya Melek
Published: December 2024

Öğrenme ve bellek, canlıların yeni bilgiler edinip depolanmasını ve gerektiğinde geri çağrılmasını sağlayan ve yaşamlarını sağlıklı bir şekilde devam ettirebilmeleri için gerekli olan bir süreçlerdir. Öğrenme ve bellek ile ilgili beynimizin ana bölümleri amigdala, hipokampus, beyincik ve prefron-tal kortekstir. Bu alanlardaki bozulmalar öğrenme ve bellek mekanizmalarını etkilemektedir. Hayvan çalışmaları insanlarda öğrenme ve bellek bozukluklarının patofizyolojisi hakkında önemli bilgiler sunarak tedavi için yeni farmakolojik ajanların keşfedilmesine katkıda bulunur. Ancak hayvan çalışmalarına başlamadan önce yapılacak çalışmanın amacını ve bu amaca ulaşabilmek için çalışmada hangi tür deney hayvanının kullanılacağını ve bu tür deney hayvanında hangi test ve modelin uygun olduğunu belirlemek, seçilen hayvan türünde modelin geçerliliği ve güvenilirliği hakkında bilgi sahibi olmak oldukça önem arz eder. Bu amaçla bu derlemede, deney hayvanla-rında yaygın olarak kullanılan öğrenme ve bellek modelleri ve testleriyle ilgili temel bilgilerin sunulması ve testler arasında bir kıyaslama yapma imkanının sunulması amaçlanmıştır.
The durable hydrophobic and antibacterial polyester textile coating
with ZnO/Zn(OH)2/starch/stearic acid composite
Authors: NARAKAEW PHIPHOP , THUNGPRASERT SIWAT , NARAKAEW SAMROENG , BAISON WIPANOOT , PROMANAN THEERAPORN , SANTAKIJ PAKORN , SUKDEE SUKEE , CHANOGKUN CHAINET , RUTTANATEERAWICHIEN KANJANA , CHAISENA APHIRUK , KRACHODNOK PIYAPORN
Published: December 2024

Herein, we prepare the antibacterial and hydrophobic polyester weaved textile using ammonium hydroxide (NH4 OH)
hydrolysis and dip-coating method which can be fabricated zinc oxide (ZnO)/zinc hydroxide Zn(OH)2 )/starch/stearic acid
(STA) composite on the textile surface. Phase identification, surface morphology, and chemistry of the composite were
revealed by Raman spectroscopy and SEM/EDX techniques. The durable hydrophobic and antibacterial properties were
investigated by water contact angle measuring, and against gram-negative Escherichia coli and gram-positive
Staphylococcus aureus bacterium as per the colony count method according to the AATCC 100 antibacterial test
method. Raman spectrum result shows the modified polyester textile sample surface, not only ZnO crystallized in the
hexagonal wurtzite structure but also Zn(OH)2 , starch, and STA composite is included. SEM images confirmed a smooth
surface of the treated fibre before washing due to using STA as a second coating agent. Despite the composite being
peeled out from the surface fibre after 5 washing cycles, the finished polyester woven textile is good durable water-
repellent. Moreover, good durable antibacterial activity against Staphylococcus aureus strains after 20 washing cycles.
The colour differences and the whiteness index of the treated polyester textile after 20 repeated washing were not
significantly changed.
Impact of taker-in speed on the characteristics of ring-spun yarn
Authors: YESHZHANOV ABILDA , ERDEM RAMAZAN , MURZABAYEVA GULZHAN , TOJIMIRZAEV SANJAR , BATYRKULOVA AKBOTA , KALDYBAEV RASHID , ZHAMBYLBAY ASSEL
Published: December 2024

In this study, experiments were carried out to determine to what extent the card sliver and final yarn quality were altered
by a gradual increment in the speed of the taker-in roller on the carding machine. The speeds of the taker-in roller have
been determined as 1200 rpm, 1400 rpm and 1600 rpm, respectively. The operating parameters of the carding machine
and other equipment in the yarn production line were kept constant. Fibre breakage, neps removal efficiency, and defect
index of samples have been measured by the AFIS PRO2 laboratory instrument. The characteristics of ring spun yarn
(17.35 tex) were tested on a Uster Tester-5 (UT-5) laboratory device. Research results revealed that the enhancement
of taker-in speed led to increased fibre breakage due to the greater impact force on the cotton fibre. This elevates the
number of short fibres in the material and also negatively affects the final yarn properties including unevenness (U%),
imperfection index (IPI), ultimate yarn strength (cN/tex), and hairiness index (H-value).
Does supplier management matter for supply chain performance?
Evidence from the textile industry
Authors: JAVED ASMA , LI QIAN , JUNEJO IKRAMUDDIN , MEMON FIZA ASHRAF , PAREKH HASEEB-UR-REHMAN , FODOR ZITA JÚLIA , HOSSAIN MD BILLAL
Published: December 2024

This study examines the impact of long-term relationships and vendor-managed inventory on supply chain performance
and the mediating role of information sharing in Pakistan’s textile industry. For testing the proposed hypotheses of the
present study, the primary data was gathered with the help of a questionnaire from past studies via a convenience
sampling strategy. Three hundred fifty questionnaires were distributed among the textile industry through the HR
department of the concerned firm. However, only 330 cases were considered for data analysis after data clearing in
SPSS version 25. Hence, the response rate is 94%. The data were analysed using SEM in Smart-PLS version 3. The
results of hypothesis testing indicated the direct effect of long-term relationships and vendor-managed inventory, which
was found to have a positive and significant impact on information sharing and supply chain performance in Pakistan’s
textile industry. Furthermore, the mediating effect of information technology between long-term relationships and vendor-
managed inventory revealed a partial mediation effect on supply chain performance. The policymakers and top
management of concerned firms should consider these variables for future strategies to get better supply chain
performance.
Sectoral analysis of textile and composite industries for value-added
manufacturing: a regional study
Authors: KARAHAN MEHMET , ARI ALİ , MAZYAR AHRARİ
Published: December 2024

This study aims to determine the main competitive features of the textile and composite industry in the Bursa region, the
centre of Türkiye’s composite and technical textile production, analyse its development, and define, evaluate, and
explore how it can be transformed into value-added elements to increase its efficiency. Adding value to textiles and
composites using these competitiveness traits is key to the industry’s continued development and prosperity. Value-
added products’ unique qualities, capabilities, and benefits set them apart from commodity items. The study determined
that traditional textile producers would face the most difficulties in the transformation. Textile companies whose technical
textile production is below 50% of their total production make up the second group. Companies producing composite
materials stated that Research and Development opportunities and quality and technical competence are the two
biggest challenges. However, companies producing composite materials are considering transforming their applications
in the fields of automotive, renewable energy, defence industry, aviation, and space. As a result, organizations wishing
to succeed in the highly competitive and ever-changing composites market must prioritize various aspects of
competitiveness.