bluuebunny/crossref_metadata_2025 huggingface dataset:
Working Capital Management and Shareholder’s Wealth Creation: Evidence from Manufacturing Companies Listed in Oman
Authors: Panigrahi Shrikant Krupasindhu , Farsi Maryam Juma Al , Kumaraswamy Sumathi , Khan Muhammad Waris Ali , Rana Faisal
Published: September 2022

Working capital management (WCM) is a key factor in the success of manufacturing companies when credit is restricted, as is the case in the current climate caused by the COVID-19 crisis. The main purpose of this paper is to investigate the relationship between working capital management, earnings quality, sales growth, and shareholders’ wealth of listed manufacturing firms in Oman. The study used balanced panel data of 31 manufacturing firms listed on the Muscat Stock Exchange (MSE) from 2004 to 2019. The study reveals that days in working capital, cash conversion cycle, payable deferred period, sales growth, and earnings quality positively affects shareholder’s wealth proxied by the return on assets, whereas, days in working capital have a negative effect on return on assets. Similarly, working capital management was found to have no influence on the earnings per share (EPS). It was also documented that sales growth and earnings quality positively impacted EPS. The study concluded that improving sales growth and earnings quality would result in shareholders’ wealth creation. The results are helpful to manufacturing companies to improve their business performance and social welfare through a direct and indirect chain of raising investments, pay, and production scales. This study adds knowledge to the body of literature on working capital management, earnings quality, and sales growth in the areas of methodology, the impact of WCM components on manufacturing firms’ shareholder value, and socioeconomic evidence from Oman.
Type of Stress Induces Differential Responses in Acer rubrum (Red Maple), but Induced Responses Have No Effect on Herbivorous Pests
Authors: Perkovich Cindy , Witcher Anthony , DeLay Grayson , Addesso Karla
Published: September 2022

Plants thrive in dynamic environments requiring adaptive strategies in response to environmental stressors. Furthermore, insect herbivores may be attracted or deterred by the expression of these traits. This study examines growth, physiological, and phytochemical adaptations of maple trees in response to stressors and how these stressors effect herbivore feeding behavior within an agricultural production system. Agricultural systems are unique because plants experience environmental stressors unique to production such as herbicide sprays and girdling. Using four environmental stressors commonly observed in agricultural production (control, mechanical defoliation, chemical defoliation, and girdling), applied to two cultivars of red maple (Acer rubrum, ‘Brandywine’ and ‘Franksred’), this study analyzed differentiation of expressed traits in a production system. Responses varied depending on cultivar and stress treatment but had no effect on insect herbivore behavior. Understanding the ecological interactions within these systems will provide information for better plant production and pest management recommendations.
Role of the Immune System in Renal Transplantation, Types of Response, Technical Approaches and Current Challenges
Authors: Etxebarria Aitor , Díez-Martín Eguzkiñe , Astigarraga Egoitz , Barreda-Gómez Gabriel
Published: September 2022

Advances over the last decades have made renal transplantation an important therapy for patients with end-stage renal disease, as the incidences of acute rejection and short-term transplant loss have been significantly reduced. However, long-term transplant survival remains a challenge in the renal transplantation community. The main causes of long-term graft loss are acute and chronic rejection, as well as the complications related to immunosuppression therapy. In spite of the breakthroughs achieved in recent years, histology is the gold standard technique to confirm the activation of the immune system against the graft with all the ensuing problems that taking biopsies brings to immunosuppressed patients. For this reason, several assays have been developed to try to monitor the immune function, but they show serious constraints owing to the fact that they require substantial laboratory work, they are not clinically available and they provide controversial results, so the combination of multiple assays is often needed to obtain a reliable diagnosis. Thus, the aim of this review is to perform a retrospective study of the immune system in renal transplantation, with special emphasis on the cutting-edge technological developments for monitoring, classification and early detection of rejection episodes in order to contribute to a better adjustment of immunosuppressive therapies and, hence, to a more personalized medicine that improves the quality of life of patients.
BARI: An Affordable Brain-Augmented Reality Interface to Support Human–Robot Collaboration in Assembly Tasks
Authors: Sanna Andrea , Manuri Federico , Fiorenza Jacopo , De Pace Francesco
Published: September 2022

Human–robot collaboration (HRC) is a new and challenging discipline that plays a key role in Industry 4.0. Digital transformation of industrial plants aims to introduce flexible production lines able to adapt to different products quickly. In this scenario, HRC can be a booster to support flexible manufacturing, thus introducing new interaction paradigms between humans and machines. Augmented reality (AR) can convey much important information to users: for instance, information related to the status and the intention of the robot/machine the user is collaborating with. On the other hand, traditional input interfaces based on physical devices, gestures, and voice might be precluded in industrial environments. Brain–computer interfaces (BCIs) can be profitably used with AR devices to provide technicians solutions to effectively collaborate with robots. This paper introduces a novel BCI–AR user interface based on the NextMind and the Microsoft Hololens 2. Compared to traditional BCI interfaces, the NextMind provides an intuitive selection mechanism based on visual cortex signals. This interaction paradigm is exploited to guide a collaborative robotic arm for a pick and place selection task. Since the ergonomic design of the NextMind allows its use in combination with the Hololens 2, users can visualize through AR the different parts composing the artifact to be assembled, the visual elements used by the NextMind to enable the selections, and the robot status. In this way, users’ hands are always free, and the focus can be always on the objects to be assembled. Finally, user tests are performed to evaluate the proposed system, assessing both its usability and the task’s workload; preliminary results are very encouraging, and the proposed solution can be considered a starting point to design and develop affordable hybrid-augmented interfaces to foster real-time human–robot collaboration.
Secure and Efficient Exchange of Threat Information Using Blockchain Technology
Authors: Pahlevan Maryam , Ionita Valentin
Published: September 2022

In recent years, sharing threat information has been one of the most suggested solutions for combating the ever-increasing number of cyberattacks, which stem from the system-wide adoption of Information and Communication Technology (ICT) and consequently endangers the digital and physical assets of organizations. Several solutions, however, were proposed to facilitate data exchange between different systems, but none were able to address the main challenges of threat sharing such as trust, privacy, interoperability, and automation in a single solution. To address these issues, this paper presents a secure and efficient threat information sharing system that leverages Trusted Automated Exchange of Intelligence Information (TAXIITM) standard and private blockchain technology to automate the threat sharing procedure while offering privacy, data integrity, and interoperability. The extensive evaluation of the solution implementation indicates its capability to offer secure communication between participants without sacrificing data privacy and overall performance as opposed to existing solutions.
Impregnation of Synthetic Saponites with Aldehydes: A Green Approach in the Intercalation of Bioactive Principles
Authors: Marchesi Stefano , Paul Geo , Guidotti Matteo , Econdi Stefano , Bisio Chiara , Carniato Fabio
Published: September 2022

Synthetic saponite clay was impregnated with either linear saturated or unsaturated aldehydes through an incipient-wetness deposition approach. To increase the aldehyde loading, saponite was also intercalated with positively charged cetyltrimethylammonium (CTA+) species, aiming to expand the clay gallery and to increase the hydrophobic character of the host solid. A multitechnique, physicochemical investigation was performed on the organic–inorganic hybrid solids. The analyses revealed that the aldehydes are mainly adsorbed on the clay particles’ surface, with a small fraction inside the interlayer space. In CTA+-modified saponites, the concentration of saturated aldehydes was higher than the one observed in the pure clay. These features are quite promising for the development of novel layered solids containing bioactive molecules for ecocompatible and economically sustainable applications, especially in agriculture, for the development of innovative hybrid materials for crop protection.
Evaluation of the Likelihood of Establishing False Codling Moth (Thaumatotibia leucotreta) in Australia via the International Cut Flower Market
Authors: Li Xingyu , Emery Robert N. , Coupland Grey T. , Ren Yonglin , McKirdy Simon J.
Published: September 2022

Kenya and some other African countries are threatened by a serious pest Thaumatotibia leucotreta (Meyrick) (Lepidoptera: Tortricidae), the false codling moth. The detection of T. leucotreta is quite difficult due to the cryptic nature of the larvae during transportation and is therefore a concern for Australia. This insect is a known pest of agriculturally important crops. Here, Maxent was used to assess the biosecurity threat of T. leucotreta to Australia. Habitat suitability and risk assessment of T. leucotreta in Australia were identified based on threatened areas under suitable climatic conditions and the presence of hosts in a given habitat. Modeling indicated that Australia is vulnerable to invasion and establishment by T. leucotreta in some states and territories, particularly areas of western and southern Australia. Within these locations, the risk is associated with specific cropping areas. As such, invasion and establishment by T. leucotreta may have serious implications for Australia’s agricultural and horticultural industries e.g., the fruit and vegetable industries. This study will be used to inform the government and industry of the threat posed by T. leucotreta imported via the cut flower industry. Targeted preventative measures and trade policy could be introduced to protect Australia from invasion by this pest.
The Comparison of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training after Coronary Artery Bypass Graft: A Systematic Review of Recent Studies
Authors: Schulté Billie , Nieborak Lisa , Leclercq Franck , Villafañe Jorge Hugo , Sánchez Romero Eleuterio A. , Corbellini Camilo
Published: September 2022

Currently, no international consensus on cardiac rehabilitation exists, leading to great variability in the intensity recommendations for training programs for cardiac patients, including those undergoing coronary artery bypass graft surgery (CABG). While some countries prefer the high-intensity interval training (HIIT) method to improve cardiorespiratory fitness, other countries opt for moderate-intensity continuous training (MICT). The aim of this systematic review was to compare the effects of HIIT and MICT on aerobic fitness and quality of life (QoL) in patients undergoing CABG with the intention of providing support for a consensus on exercise therapy. Methods: A systematic review of randomized controlled trials (RCTs) was conducted using the online publication databases PubMed, the Cochrane Library and the Bibliothèque nationale du Luxembourg (BnL) covering the last ten years to July 2022. Relevant identified studies respecting the inclusion/exclusion criteria were selected, screened and extracted by four reviewers. Furthermore, the methodological quality of the clinical trials was assessed using the PEDro scale, which was reinforced using the Cochrane Risk of Bias Tool for Randomized Trials (RoB2) for the evaluation of the risk of bias to provide more detail in the evaluation. The certainty of the evidence analysis was established using different levels of evidence in accordance with the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. Results: A total of 379 patients from five RCTs diagnosed with coronary artery disease, including patients undergoing CABG, performed aerobic exercise over different time periods and were assessed based on peakVO2, VO2max and QoL. Overall, both training methods provided improvements in cardiorespiratory fitness and quality of life, with greater changes in HIIT groups. Conclusion: Both trainings methods provide improvements in cardiorespiratory fitness and QoL, with greater increases from HIIT. The moderate quality of evidence supports the use of HIIT and MICT to improve cardiorespiratory fitness and QoL.
Outcome Comparison of Acute Respiratory Distress Syndrome (ARDS) in Patients with Trauma-Associated and Non-Trauma-Associated ARDS: A Retrospective 11-Year Period Analysis
Authors: Engelhardt Lilian Jo , Olbricht Claudio , Niemann Marcel , Graw Jan Adriaan , Hunsicker Oliver , Weiss Björn , Bünger Victoria , Weber-Carstens Steffen , Boie Sebastian Daniel , Piper Sophie K. , Balzer Felix , Menk Mario
Published: September 2022

(1) Background: Acute respiratory distress syndrome (ARDS) is a rare complication in multiply injured patients. Due to the rarity of ARDS development after trauma, little is known about outcomes of patients with trauma-associated ARDS compared to patients with non-trauma-associated ARDS. (2) Methods: This retrospective analysis included n = 1038 ARDS patients admitted to the ARDS center of Charité—Universitätsmedizin Berlin between 2007 and 2018. Patients with trauma-associated ARDS (n = 62) were compared to patients with non-trauma-associated ARDS (n = 976). In a secondary analysis, patients from the group with non-trauma-associated ARDS were 1:1 nearest neighbor matched to patients with trauma-associated ARDS. The primary outcomes were 28-day in-hospital mortality, 60-day in-hospital mortality, and overall in-hospital mortality. (3) Results: Overall in-hospital mortality in trauma-associated ARDS was 29.0% compared to 40.5% in all patients with non-trauma-associated ARDS (p = 0.074). The in-hospital mortality rate in matched patients with non-trauma-associated ARDS (33.9%) was comparable to the trauma-associated ARDS cohort (p = 0.701). Kaplan–Meier curves indicated time-sensitive variations in 28-day and 60-day in-hospital survival. (4) Conclusion: Mortality was not different in patients with trauma-associated ARDS compared to patients with non-trauma-associated ARDS. Survival rate in the Kaplan–Meier curves stabilized after the critical initial phase and throughout the further 60-day period in patients with trauma-associated ARDS compared to patients with non-trauma-associated ARDS. Since this divergence was less pronounced in the matched cohort, it may be related to the younger age, fewer comorbidities, and lower ARDS severity in patients with trauma-associated ARDS. Patients with trauma-associated ARDS remain a very different cohort compared to patients with non-trauma-associated ARDS. Therefore, the outcome comparison is limited, even after matching.
Influence of Codiagnosis of Chronic Fatigue Syndrome and Habitual Physical Exercise on the Psychological Status and Quality of Life of Patients with Fibromyalgia
Authors: Hinchado María Dolores , Otero Eduardo , Navarro María del Carmen , Martín-Cordero Leticia , Gálvez Isabel , Ortega Eduardo
Published: September 2022

Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are two diseases that are frequently codiagnosed and present many similarities, such as poor tolerance to physical exercise. Although exercise is recommended in their daily routine to improve quality of life, little is known about how CFS codiagnosis affects that. Using scientifically validated questionnaires, we evaluated the psychological state and quality of life of patients with FM (n = 70) and how habitual physical exercise (HPE) reported by patients with only FM (FM-only n = 38) or codiagnosed with CFS (FM + CFS, n = 32) influences those aspects. An age-matched reference group of “healthy” women without FM (RG, n = 70) was used. The FM-only group presented a worse psychological state and quality of life compared to RG, with no influence of CFS codiagnosis. The patients of the FM-only and FM + CFS groups who perform HPE presented better levels of stress and state anxiety, but with no differences between them. Depression and trait anxiety improved only in women with just FM. CFS codiagnosis does not worsen the psychological and quality of life impairment of FM patients and does not have a great influence on the positive effect of HPE.
Now Is the Time to Bring a Common but Unpopular Noncommunicable Disease into Focus: Peripheral Arterial Disease Takes Limbs and Lives, but It Must Also Touch Our Hearts!
Authors: Behrendt Christian-Alexander , Peters Frederik , Rother Ulrich
Published: September 2022

We have all learned a great deal from the ongoing pandemic that has already taken more than five million lives in less than three years [...]
Comparative Study of Helicobacter pylori-Infected Gastritis in Okinawa and Tokyo Based on the Kyoto Classification of Gastritis
Authors: Oki Shotaro , Takeda Tsutomu , Hojo Mariko , Uchida Ryota , Suzuki Nobuyuki , Abe Daiki , Ikeda Atsushi , Akazawa Yoichi , Ueyama Hiroya , Nojiri Shuko , Hoshino Shinichi , Shokita Hayashi , Nagahara Akihito
Published: September 2022

The incidence of gastric cancer in Okinawa Prefecture is the lowest in Japan, which is attributed to differences in strains of Helicobacter pylori in Okinawa and other prefectures in Japan. Our aim was to compare the endoscopic findings of H. pylori-infected gastric mucosa in Okinawa and Tokyo. Patients who underwent upper gastrointestinal endoscopy (UGI) at Northern Okinawa Medical Center (Okinawa group) and Juntendo University Hospital (Tokyo group) from April 2019 to March 2020 were included. Patients diagnosed with H. pylori-infected gastric mucosa were retrospectively compared between the Okinawa and Tokyo groups according to the Kyoto Classification of Gastritis. The numbers of subjects (Okinawa/Tokyo) were 435/352, male/female ratio was 247:188/181:171, and age was 53.3 ± 14.7/64.6 ± 14.3 (mean ± standard deviation) years. Regarding the Kyoto Classification of Gastritis, the prevalence (Okinawa/Tokyo) of the closed type of atrophic gastritis was 73%/37% (p < 0.001), diffuse redness 80%/84% (p = 0.145), mucosal swelling 46%/46% (p = 0.991), enlarged fold 26%/32% (p = 0.048), spotty redness 77%/68% (p = 0.002), sticky mucus 17%/36% (p < 0.001), and intestinal metaplasia 32%/42% (p < 0.001). Age analysis also revealed that closed-type atrophy and spotty redness were more frequent in the Okinawa group than in the Tokyo group. There may be regional differences in endoscopic findings of H. pylori-infected gastric mucosa between Okinawa and Tokyo.
Simple Application and Adherence to Gout Guidelines Enables Disease Control: An Observational Study in French Referral Centres
Authors: Jauffret Charlotte , Ottaviani Sébastien , Latourte Augustin , Ea Hang-Korng , Graf Sahara , Lioté Frédéric , Bardin Thomas , Richette Pascal , Pascart Tristan
Published: September 2022

Background: In a context of therapeutic inertia, the French Society of Rheumatology (SFR) published its first recommendations on gout in 2020, which were deliberately simple and concise. The objectives of the study were to determine the profile of patients referred to French gout-expert centres, and to examine the results of their management and the factors leading to those results. Methods: Three hundred patients attending a first visit for gout management in three French referral centres were retrospectively and randomly included in this multicentre observational study. Visits were performed at baseline (M0) and scheduled for month 6 (M6), month 12 (M12), and month 24 (M24). Results: Patients were 81% male and had a mean age 62.2 ± 15.2 years. Management followed French recommendations after the baseline visit in 94.9% of cases. SU levels were below 6.0 mg/dL in 59.4% of patients at M6, 67.9% at M12, and 78.6% at M24, with increasing clinical improvement (i.e., flare decrease) over 2 years of follow-up. At M24, 50% of patients were treated with allopurinol (313 ± 105 mg/d), which exceeded renal restrictions of doses in 61.5% of them, and 48.2% received febuxostat (84 ± 36 mg/d). The need for a sufficient dosage of ULT was the only predictive factor found for successful achievement of SU levels < 6.0 mg/dL at a given visit. Conclusions: Simple application of gout-management guidelines is feasible in clinical practice and is efficient, with a majority of patients achieving SU targets and clinical improvement.
Classification und Treatment Algorithm of Small Bowel Perforations Based on a Ten-Year Retrospective Analysis
Authors: Onken Flurina , Senne Moritz , Königsrainer Alfred , Wichmann Dörte
Published: September 2022

Background: Small bowel perforations are a rare diagnosis compared with esophageal, gastric, and colonic perforations. However, small bowel perforations can be fatal if left untreated. A classification of small bowel perforations or treatment recommendations do not exist to date. Methods: A retrospective, monocentric, code-related data analysis of patients with small bowel perforations was performed for the period of 2010 to 2019. Results: Over a 10-year period, 267 cases of small bowel perforation in 257 patients (50.2% male and 49.8% female; mean age of 60.28 years) were documented. Perforation’s localization was 5% duodenal, 38% jejunal, 39% ileal, and 18% undocumented. Eight etiologies were differentiated: iatrogenic (41.9%), ischemic (20.6%), malignant (18.9%), inflammatory (8.2%), diverticula-associated (4.5%), traumatic (4.5%), foreign-body-associated (1.9%), and cryptical (1.5%) perforations. Operative treatment combined with antibiotics was the most commonly used therapeutic approach (94.3%). The mortality rate was 14.23%, with highest rate for patients with ischemic perforations. Discussion: An algorithm for diagnostic and therapeutic steps was established. Furthermore, it was found that small bowel perforations are rare events with poor outcomes. Time to diagnosis and grade of underlying disease are the most essential parameters to predict perforation-associated complications.
Face Transplant: Indications, Outcomes, and Ethical Issues—Where Do We Stand?
Authors: La Padula Simone , Pensato Rosita , Pizza Chiara , Coiante Edoardo , Roccaro Giovanni , Longo Benedetto , D’Andrea Francesco , Wirz Francesco Saverio , Hersant Barbara , Meningaud Jean Paul
Published: September 2022

Background: The addition of face allotransplantation (FT) to the head and neck reconstructive surgery arsenal has started a true revolution. This study is aimed at providing an extensive analysis of the current practice of composite tissue allotransplantation. Moreover, a thorough description of pre-procedural, intra-operative, and post-procedural settings, indications, contraindications, outcomes, ethical considerations, and future perspectives is provided. Methods: The authors’ experience was supplemented with a literature review performed by using the PubMed, MEDLINE, and Embase databases on 21 February 2022. The search terms used were “face transplantation indications”, “face transplantation complications”, and “face transplantation ethical issues”. Results: The most recent achievements and long-term clinical sequelae of FT are classified and summarized. A large number of records (4435) were identified. Seventy-five articles were assessed for eligibility. Publications without new data and reports with a patient follow-up < 5 years were excluded. Nineteen articles met the criteria for inclusion. Conclusions: The most recent achievements in the field of FT may be combined with cutting-edge regenerative medicine procedures and innovative immunological processing. It is paramount to build strong international networks between the world FT experts in order to achieve higher-level outcomes and reduce the complication rate. Nevertheless, the utmost caution is required in patient selection, clinical assessment, strict follow-up, and rejection management.
Strategies to Overcome HLA Sensitization and Improve Access to Retransplantation after Kidney Graft Loss
Authors: Leal Rita , Pardinhas Clara , Martinho António , Sá Helena Oliveira , Figueiredo Arnaldo , Alves Rui
Published: September 2022

An increasing number of patients waitlisted for kidney transplantation have a previously failed graft. Retransplantation provides a significant improvement in morbidity, mortality, and quality of life when compared to dialysis. However, HLA sensitization is a major barrier to kidney retransplantation and the majority of the highly sensitized patients are waiting for a subsequent kidney transplant. A multidisciplinary team that includes immunogeneticists, transplant nephrologists and surgeons, and adequate allocation policies is fundamental to increase access to a kidney retransplant. A review of Pubmed, ScienceDirect, and the Cochrane Library was performed on the challenges of kidney retransplantation after graft loss, focusing on the HLA barrier and new strategies to overcome sensitization. Conclusion: Technical advances in immunogenetics, new desensitization protocols, and complex allocation programs have emerged in recent years to provide a new hope to kidney recipients with a previously failed graft.
Preliminary Investigation on Micro-Needling with Low-Level LED Therapy and Growth Factors in Hair Loss Related to COVID-19
Authors: Gentile Pietro
Published: September 2022

The incidence of hair loss (HL) and telogen effluvium (TE) has increased due to the spread of the coronavirus disease (COVID-19) induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). New biotechnologies based on micro-needling (MND) with Low-Level LED Therapy (LLLT) and Growth Factors (GFs) used for hair re-growth (HR-G) in Androgenetic Alopecia (AGA) need to be standardized also in HL and TE related to COVID-19. This article aims to describe the preliminary clinical results obtained from an open-label case-series observational study. MND with LLLT and GFs was used in patients affected by HL and TE-related to COVID-19. In total, 10 patients (6 men were identified in stage I–III vertex according to the Norwood–Hamilton scale, and 4 women were identified in stage I–II according to the Ludwig scale) were enrolled and analyzed after screening (exclusion and inclusion criteria evaluation). HR-G assessment was analyzed through photography, physician’s and patient’s global assessment scale, and standardized phototrichograms during a short follow-up: T0—baseline; T1—20 weeks (wks). In the targeted area computerized trichograms showed encouraging results with a hair density increase of 11 ± 2 hairs/cm2 at T1 after 20 wks (20 wks vs. 0 wks) compared with baseline (58 ± 2 hairs/cm2 at T1 versus 47 ± 2 hairs/cm2 at baseline) with a not quite statistically significant difference in HR-G (p = 0.0690). The preliminary effectiveness of MND with LLLT and GFs use has been demonstrated in mild-to-moderate HL and TE related to COVID-19. Further controlled trials are required to confirm these preliminary results.
The Correlation of Arterial Stiffness Parameters with Aging and Comorbidity Burden
Authors: Fantin Francesco , Giani Anna , Trentin Monica , Rossi Andrea P. , Zoico Elena , Mazzali Gloria , Micciolo Rocco , Zamboni Mauro
Published: September 2022

The aim of the study was to evaluate the relationships between carotid-femoral pulse wave velocity (PVW-cf), cardio-ankle vascular index (CAVI) and CAVI0 (which is a mathematical elaboration of CAVI, theoretically less dependent on blood pressure), age and comorbidity burden. Furthermore, 183 patients (119 female, mean age 67.5 ± 14.3 years) referred to the Geriatric Ward and Outpatient Clinic at Verona University Hospital were included; demographic, clinical and blood analysis data were collected. Charlson Comorbidity Index (CCI), PVW-cf, CAVI and CAVI 0 were obtained. Significant correlations were found between CAVI, CAVI0, PVW-cf and both age (r = 0.698, r = 0.717, r = 0.410, respectively p < 0.001 for all) and CCI, (r = 0.654; r = 0.658; r = 0.448 respectively and p < 0.001 for all), still significant after adjustment for several variables. In a stepwise multiple regression model, considering several variables, CCI was the only predictor of PWV-cf, whereas age and CCI were significant predictors of both CAVI and CAVI 0. In conclusion, all arterial stiffness indexes are associated with CCI and aging; the latter correlation is more evident for CAVI and CAVI 0 than for PVW-cf. Arterial stiffness parameters can complement the characterization of patients affected by a remarkable comorbidity burden across aging; arterial stiffening might mirror the complexity of these individuals.
The Face Deepfake Detection Challenge
Authors: Guarnera Luca , Giudice Oliver , Guarnera Francesco , Ortis Alessandro , Puglisi Giovanni , Paratore Antonino , Bui Linh M. Q. , Fontani Marco , Coccomini Davide Alessandro , Caldelli Roberto , Falchi Fabrizio , Gennaro Claudio , Messina Nicola , Amato Giuseppe , Perelli Gianpaolo , Concas Sara , Cuccu Carlo , Orrù Giulia , Marcialis Gian Luca , Battiato Sebastiano
Published: September 2022

Multimedia data manipulation and forgery has never been easier than today, thanks to the power of Artificial Intelligence (AI). AI-generated fake content, commonly called Deepfakes, have been raising new issues and concerns, but also new challenges for the research community. The Deepfake detection task has become widely addressed, but unfortunately, approaches in the literature suffer from generalization issues. In this paper, the Face Deepfake Detection and Reconstruction Challenge is described. Two different tasks were proposed to the participants: (i) creating a Deepfake detector capable of working in an “in the wild” scenario; (ii) creating a method capable of reconstructing original images from Deepfakes. Real images from CelebA and FFHQ and Deepfake images created by StarGAN, StarGAN-v2, StyleGAN, StyleGAN2, AttGAN and GDWCT were collected for the competition. The winning teams were chosen with respect to the highest classification accuracy value (Task I) and “minimum average distance to Manhattan” (Task II). Deep Learning algorithms, particularly those based on the EfficientNet architecture, achieved the best results in Task I. No winners were proclaimed for Task II. A detailed discussion of teams’ proposed methods with corresponding ranking is presented in this paper.
BIoU: An Improved Bounding Box Regression for Object Detection
Authors: Ravi Niranjan , Naqvi Sami , El-Sharkawy Mohamed
Published: September 2022

Object detection is a predominant challenge in computer vision and image processing to detect instances of objects of various classes within an image or video. Recently, a new domain of vehicular platforms, e-scooters, has been widely used across domestic and urban environments. The driving behavior of e-scooter users significantly differs from other vehicles on the road, and their interactions with pedestrians are also increasing. To ensure pedestrian safety and develop an efficient traffic monitoring system, a reliable object detection system for e-scooters is required. However, existing object detectors based on IoU loss functions suffer various drawbacks when dealing with densely packed objects or inaccurate predictions. To address this problem, a new loss function, balanced-IoU (BIoU), is proposed in this article. This loss function considers the parameterized distance between the centers and the minimum and maximum edges of the bounding boxes to address the localization problem. With the help of synthetic data, a simulation experiment was carried out to analyze the bounding box regression of various losses. Extensive experiments have been carried out on a two-stage object detector, MASK_RCNN, and single-stage object detectors such as YOLOv5n6, YOLOv5x on Microsoft Common Objects in Context, SKU110k, and our custom e-scooter dataset. The proposed loss function demonstrated an increment of 3.70% at APS on the COCO dataset, 6.20% at AP55 on SKU110k, and 9.03% at AP80 of the custom e-scooter dataset.
Numerical Study on Dynamic Characteristics of Vehicle Entering Water at High Speed
Authors: Liu Zhenpeng , Shi Yao , Pan Guang , Zhao Hairui
Published: September 2022

Aiming at a design for buffering and load reduction configuration for a large-scale (diameter greater than 500 mm) vehicle entering water at high speed (greater than 100 m/s), a numerical model for a vehicle entering water at high speed was employed based on an arbitrary Lagrange-Euler (ALE) algorithm. Combined with modal analysis and shock response spectrum, the influence of the head cap on the dynamic characteristics of the structure was analyzed. The results showed that the peak value and pulse width of the impact load on the vehicle increased with the increase in the speed of water entry. The existence of the head cap increased the complexity of the forces on the vehicle during the process of water entry. The initial formation of the cavity was greatly affected by the head cap. The head cap and the vehicle separated in the later stage of the water entry. During the process of water entry, the shell of the vehicle was mainly compressed and bent and the head cap reduced the deformation. The relevant conclusions of this paper can provide some input for the design of a new buffering structure and vehicle shell.
Three New Species of Clonostachys (Hypocreales, Ascomycota) from China
Authors: Zeng Zhao-Qing , Zhuang Wen-Ying
Published: September 2022

Three new species of Clonostachys are introduced based on specimens collected from China. Clonostachys chongqingensis sp. nov. is distinguished by pale yellow to pale orange-yellow perithecia with a very low papilla, clavate to subcylindrical asci possessing ellipsoidal to elongate-ellipsoidal spinulose ascospores 13–16 × 4.5–5.5 μm; it has acremonium- to verticillium-like conidiophores and ellipsoidal to rod-shaped conidia. Clonostachys leptoderma sp. nov. has pinkish-white subglobose to globose perithecia on a well-developed stroma and with a thin perithecial wall, clavate to subcylindrical asci with ellipsoidal to elongate-ellipsoidal spinulose ascospores 7.5–11 × 2.5–3.5 μm; it produces verticillium-like conidiophores and ellipsoidal to subellipsoidal conidia. Clonostachys oligospora sp. nov. features solitary to gregarious perithecia with a papilla, clavate asci containing 6–8 smooth-walled ascospores 9–17 × 3–5.5 μm; it forms verticillium-like conidiophores and sparse, subfusiform conidia. The morphological characteristics and phylogenetic analyses of combined nuclear ribosomal DNA ITS1-5.8S-ITS2 and beta-tubulin sequences support their placement in Clonostachys and their classification as new to science. Distinctions between the novel taxa and their close relatives are compared herein.
New Insights into Lichenization in Agaricomycetes Based on an Unusual New Basidiolichen Species of Omphalina s. str.
Authors: Zhang Tingting , Zhu Xinyu , Vizzini Alfredo , Li Biting , Cao Zhenghua , Guo Wenqing , Qi Sha , Wei Xinli , Zhao Ruilin
Published: September 2022

The genus Omphalina is an ideal genus for studying the evolutionary mechanism of lichenization. Based on molecular phylogeny using ITS and nuLSU sequences by means of Bayesian and maximum likelihood analyses and morphological examination, combining the existence of green algae in basidiomata stipe and a Botrydina-type vegetative thallus, we described a bryophilous new basidiolichen species, Omphalina licheniformis, from a residential area of Jiangxi Province, China. This finding of unusual new basidiolichen species updated our understanding of the delimitation of Omphalina, indicating that both non-lichen-forming and lichen-forming fungal species are included simultaneously. The presence of algal cells in the basidiomata should receive more attention, as this would be helpful to distinguish more potential basidiolichens and explore the cryptic species diversity. This work provides new insights and evidence for understanding the significance of lichenization during the evolution of Agaricomycetes.
Peptaibol Production and Characterization from Trichoderma asperellum and Their Action as Biofungicide
Authors: Alfaro-Vargas Pamela , Bastos-Salas Alisson , Muñoz-Arrieta Rodrigo , Pereira-Reyes Reinaldo , Redondo-Solano Mauricio , Fernández Julián , Mora-Villalobos Aníbal , López-Gómez José Pablo
Published: September 2022

Peptaibols (Paib), are a class of biologically active peptides isolated from soil, fungi and molds, which have interesting properties as antimicrobial agents. Paib production was optimized in flasks by adding sucrose as a carbon source, 2-aminoisobutyric acid (Aib) as an additive amino acid, and F. oxysporum cell debris as an elicitor. Paib were purified, sequenced and identified by High-performance liquid chromatography (HPLC)coupled to mass spectrometry. Afterward, a Paib extract was obtained from the optimized fermentations. The biological activity of these extracts was evaluated using in vitro and in vivo methods. The extract inhibited the growth of specific plant pathogens, and it showed inhibition rates similar to those from commercially available fungicides. Growth inhibition rates were 92.2, 74.2, 58.4 and 36.2% against Colletotrichum gloeosporioides, Botrytis cinerea, Alternaria alternata and Fusarium oxysporum, respectively. Furthermore, the antifungal activity was tested in tomatoes inoculated with A. alternata, the incidence of the disease in tomatoes treated with the extract was 0%, while the untreated fruit showed a 92.5% incidence of infection Scanning electron microscopy images showed structural differences between the fungi treated with or without Paib. The most visual alterations were sunk and shriveled morphology in spores, while the hyphae appeared to be fractured, rough and dehydrated.
Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature
Authors: Taghizadeh Hadi , Taghizadehghalehjoughi Ali , Yildirim Serkan , Ozkaraca Mustafa , Genc Sidika , Yeni Yesim , Mokresh Muhammed Yasser , Hacimuftuoglu Ahmet , Tsatsakis Aristidis , Tsarouhas Konstantinos
Published: September 2022

Hypertension, as a primary risk factor for many fatal disorders, is prevalent in the elderly. There is wide literature on hypertension dealing with its biological and/or biochemical aspects; however, limited research is available on the multifactorial nature of hypertension from a mechanobiological standpoint. This study intended to study in parallel histopathological alterations and deviated protein expressions with the mechanical behavior of the hypertensive tissues. The Goldblatt (2K1C) method was chosen for induction of renovascular hypertension in rabbits. The microstructural and immunohistological characteristics of the aortic, pancreatic, and brain vasculature were investigated. The mechanical properties of the aortic tissue were also evaluated using biaxial tensile tests. Our findings indicated severe hypertrophy of the hypertensive vessels and declined content of intact smooth muscle cells. Most of the collagen I content of the wall was compromised and less functional type III collagen was highly expressed. Reversed collagen I to collagen III ratio was the main contributor to the hypertrophic and less stiff hypertensive vessel walls. The multifactorial nature of hypertension is illustrated, and smooth muscle cell detachment is identified as the sign of described degenerative cascades all along the arterial tree.
Gender Differences in Oral Health: Self-Reported Attitudes, Values, Behaviours and Literacy among Romanian Adults
Authors: Sfeatcu Ruxandra , Balgiu Beatrice Adriana , Mihai Christina , Petre Ana , Pantea Mihaela , Tribus Laura
Published: September 2022

A topic that has been less researched on, especially in Romania, is the identification of gender differences in oral health. The present scientific research used an online survey to assess the attitudes (dental beliefs survey-R/R-DBS), the values (oral health values scale/OHVS), the behaviours (dental neglect scale/DNS), and the literacy (oral health literacy scale/OHLS) related to oral health and to dental professional services in the case of a sample of 600 Romanian adults (Meanage = 30.84). The relation between the level of knowledge as a predictor of attitudes and values related to oral health was analysed by the means of a structural equation based on the partial least square method (PLS-SEM). The results show that women have more positive attitudes towards dental medical services, higher oral health values, better self-care behaviours, and higher oral health literacy than men. In the case of men, attitudes and behaviours related to self-care are influenced by their oral health literacy and level of education; in the case of women, the latter are influenced only by their level of oral health literacy. The impact that knowledge in oral health has on attitudes, values, and behaviours was highlighted. The differences in attitudes and values related to oral health between the two genders can be accounted for by the differences in formal and informal education (studies and oral health literacy, respectively).
Social Networks Marketing, Value Co-Creation, and Consumer Purchase Behavior: Combining PLS-SEM and NCA
Authors: Arbabi Farzin , Khansari Seyed Mohammad , Salamzadeh Aidin , Gholampour Abbas , Ebrahimi Pejman , Fekete-Farkas Maria
Published: September 2022

Given the mediating role of value co-creation, this paper tries to demonstrate how social network marketing (SNM) could influence consumer purchase behavior (CPB). The proposed hypotheses are empirically tested in this study using a PLS-SEM and Necessary Condition Analysis (NCA) method combination. The novel methodology adopted in this study includes the use of NCA, IPMA matrix, permutation test, CTA, and FIMIX. The assessment of the outer model, the inner model, the NCA matrix, and the IPMA matrix are the four steps that the paper takes. Instagram users with prior experience making purchases online made up the statistical population of the study. Four hundred twenty-seven questionnaires were analyzed by SmartPLS3 software. Based on the findings, SNM positively and significantly influenced economic, enjoyment, and relational values. Furthermore, these three types of values significantly and directly influenced CPB. For CPB, the model accounted for 73.8% of the variance. The model had high predictive power because it outperformed the PLS-SEM benchmark for all of the target construct’s indicators in terms of root mean square error (RMSE). According to the NCA’s findings, SNM, economic, recreational, and relational values are necessary conditions for CPB that are meaningful (d ≥ 0.1) and significant (p < 0.05). Four prerequisites must be met for CPB to reach a 50% level: relational value at no less than 8.3%, enjoyment value at no less than 16.7%, economic value at no less than 33.3%, and SNM at no less than 31.1%. The highest importance score for SNM is shown to be 0.738, which means that if Instagram channels improve their SNM performance by one unit point, their overall SNM will also improve by 0.738.
Delimiting Rural Areas: Evidence from the Application of Different Methods Elaborated by Italian Scholars
Authors: Cattivelli Valentina
Published: September 2022

The present text illustrates the methods developed by Italian scholars to delimit rural areas in the period 2005–2020 and compares the relative territorial representations graphically and quantitatively. In that period, Italian scholars experimented with several methods to delimit territories because they are pressed by the desire to find the one that best described the territories, i.e., was both locally relevant and internationally comparable. This pressure originates from the need to map intermediate territories and redesign urban–rural extremes. In addition, it depends on the need to efficiently allocate national and European funds and circumscribe the corresponding program areas. Finally, it is also strongly related to the desire to internationally compare the economic, social, and environmental performance of homogeneous and permanently delimited territories. The text describes the key features of the methods they developed, such as adopted statistical technique and the spatial unit, the processed variables, and the territorial typologies. The results reveal that municipalities and provinces are preferred as spatial units, while economic and demographic indicators are the most used and elaborated through both relatively simple and articulated statistical techniques. The resulting territorial representations show different degrees of ruralization. While some methods design a mostly weakly urban and rural Italy, others completely ignore rural territories. Where they delimit them, the percentage of the population living in each territorial typology varies a lot. No scholars have either applied the methods at an international level or replicated them in other studies.
Preliminary Research on Agricultural Cultivation Decreasing Amino Sugar Accumulation in Calcareous Soils in Subtropical Karst Region of China
Authors: Zhou Mengxia , Yang Hui , Zhu Tongbin , Zhang Cheng , Zhu Degen
Published: September 2022

Soil microbial residues play an important role in the formation and stabilization of soil organic matter and can be quantitatively characterized by amino sugars. However, the response of soil microbial residues to agricultural cultivation in karst areas remains unclear. In this study, we collected soil samples from natural reserved land as well as five plantation forests dominated by Citrus trees cultivated for 0, 1, 5, 15, 30 years to examine the effects of agricultural cultivation on the content of microbial residues (amino sugar analysis). Results showed that: (1) Soil Amino Sugars (ASs) contents were significantly reduced after agricultural cultivation along with the sharp decrease in soil organic carbon (SOC). After 30 years of cultivation, the contents of total ASs, glucosamine (GluN), galactosamine (GalN), and muramic acid (MurA) in cultivated soils decreased by 58.22%, 55.30%, 27.11%, respectively, compared with 0 yr.; (2) Microbial residual carbon contribution to SOC increased from 34.11% to 81.33% after 30 years of cultivation, including fungal residual carbon (FRC) (25.79% to 48.6%) and bacterial residual carbon (BRC) (8.32% to 32.72%); (3) Soil GluN/MurA values tended to decrease with increasing cultivation years. The results highlight the significant effect of cultivation years on amino sugar accumulation. It indicates that the years of reclamation in karst areas have different impacts on the organic fractions derived from various microbial communities in the soil organic matter pool, and the microbial residues indicated by amino sugar are of great significance for the interception of soil organic matter.