bluuebunny/crossref_metadata_2025 huggingface dataset:
Politics in Literature: The Atmosphere and Responses of the Governed Peoples of Yugoslavia in the Oral and Written Literature
Authors:   East European and Balkan Institute, Kim Sang Hun
Published: June 2022

This paper examines the historical and political aspects of the South Slavs from the perspective of ‘dominated’ and ‘subjugated’ based on the framework of oral literature. In addition, by examining the development of oral literature of Serbia, Croatia, and Bosnia-Herzegovina, the characteristics of oral literature history of each nation were also examined. In terms of the preservation and development of oral literature, the most important factor is the ‘ethnic characteristics’ of an individual nation as well as ‘religion’ and ‘whether or not to accept the written word’. Of course, as considered in this study, it is very natural for national resistance to arise from the ruling peoples of the Ottoman Empire, including Serbia, who were directly the target of exploitation and oppression. On the other hand, it is also understandable that the sense of national resistance was not as great as in the case of regions and peoples where the domination of the Ottoman Empire was not direct, such as Croatia and Slovenia.
The common characteristics and differences were examined through the historical background of the peoples of Yugoslavia and the historical characteristics of oral literature. And in Chapter 3, through the analysis of specific oral literature works, we grasped the various responses and emotions of the ruled people against the oppression and injustice of the Ottoman Turk Empire. In conclusion, it can be understood that the peoples of Yugoslavia tried to show the indomitable national spirit as the ruled people who did not give in to the dominant people through oral literature. However, from this perspective, it can be seen that the Croatian and Slovenian peoples did not have individual national resistance through oral literature works.
Forensic Accounting: Innovative Tool for Corporate Sector
Authors: Gupta Sumeet
Published: June 2022

In the present scenario, there has been tremendous increase in the Financial Frauds, White Collar Crimes, and Professional Negligence etc. due to flourishing businesses and diversified operations. Recent Accounting frauds and requirement of transparency as well as governance gives the rise to the need of Forensic Accounting in the Corporate Sector. Internal and External auditors can only check the arithmetical accuracy and the compliance with the Accounting Standards, Auditing Standards and Policies in the preparation of Books of Accounts. The new arena of accounting world be helpful to detect the suspected business transactions, frauds and other criminal offences.
An analysis of Balance Sheet with reference to State Bank of India
Authors: Dr. Satyanarayana Chadaram  , Dr. Sonali Gopal Kale
Published: June 2022

A balance sheet is a financial statement which indicates in that reports a company's assets, liabilities, and shareholder equity. The balance sheet is very important and one of the three core financial statements which are used to assess a business. Balance Sheet provides a detailed report of a company's finances in other words what business it owns and owes as of the date of publication. A company's balance sheet provides a remarkable amount of insight into its solvency and business dealings. A balance sheet contains of three primary sections they are assets, liabilities, and equity.
SOCIAL ECONOMIC ANALYSIS OF THE TOURISM SECTOR
Authors: Musliha
Published: June 2022

Introduction: The tourism sector has now developed into the largest industry for economic growth in Indonesia; this can be seen from the increasing development of the number of tourist visits, both domestic and foreign tourists. The purpose of this study was to determine the impact of the existence of the Sikembang Park tourist attraction on the socioeconomics of business actors in Kembanglangit Village.
Methods: The method used in this study is a descriptive method with a qualitative approach.
Results: The results of this study are that the Sikembang Park tourist attraction has a positive impact in terms of economy and socio-culture. The economic impact is to increase income and create jobs and business opportunities. As well as the impact on the social life, namely a closer  relationship between the people of Kembanglangit Village.Conclusion and suggestion: Based on the discussion regarding the Impact of the Existence of the Sikembang Park Tourism Object on the Socio-Economic Condition of Business Actors in Kembanglangit Village, it can be concluded that the existence of the Sikembang Park tourism object has a positive impact on the community's economic activities which consist of increasing income and opening up job opportunities and business opportunities. Communities around tourist sites get additional work as food and beverage traders. In addition, the Sikembang Park tourist attraction also has an impact on the social life of the Kembanglangit Village community, namely by creating a closer relationship between the people in Kembanglangit Village.
PARENTAL RISK AVERSION AND INVESTMENT IN CHILDREN’S EDUCATION
Authors: Nurrachmat Janaska , Sastiono Prani
Published: June 2022

Introduction: The purpose of this study is to investigate the relationship between risk aversion and spending in children’s education. Spending in children’s education can be classified as an investment with uncertain outcomes and the return might yield in a relatively long time. It is predicted in this study that risk aversion will have negative impact on spending in children’s education.
Methods: This study uses IFLS data and two-period panel regression. Multiple time periods are applied to demonstrate time-varying risk aversion.
Results: The results suggest that lower degree of parental risk aversion increases the spending on children’s education, which confirms the theory.
Conclusion and suggestion: The result showed that risk aversion significantly affects the spending on children’s education. As a consequence, the government should provide clear information about how important an education is, especially a higher degree. Providing the information may drive the parent to not view education for children as a risky investment.
BRAND TRUST AND CUSTOMER LOYALITY IN SERVICE COMPANIES HEALTH
Authors: Munawaroh Emi , Rianto
Published: June 2022

Introduction: This study was conducted to examine the effect of trust in brand (brand characteristic, company characteristic, and customer - brand characteristic) on brand loyalty in hospital patients.
Methods: The method used in this study is a quantitative descriptive research method with a multiple linear regression analysis approach using 100 respondents who have used the services of RSUD Dr. Sudirman Kebumen.
Results: The results of this study indicate that trust in brand has a positive effect on brand loyalty, either partially for each dimension of brand characteristic, company characteristic, and customer-brand characteristic or simultaneously. Furthermore, customer-brand characteristic is the dominant variable even though the difference is not great. Therefore, it can be concluded that, in building brand loyalty, it requires building trust from the brand with characteristics starting from the brand itself, and how the patient's relationship with the brand is established.
Conclusion and suggestion The author finds that building brand loyalty in service companies, especially health services at regional companies, requires good brand trust management. This is a new finding because previous research has focused on goods industry. Brand loyalty is focused not only on a tangible product industry, but even health service companies need good brand awareness, especially trust, to be able to maintain customer loyalty to the brand.
Digital Technology Environment and Humanities Classics
Authors:   The Research Of The Korean Classic, Kim Jae-hee
Published: June 2022

This study examines the role of humanities classics in the era of the accelerating Digital Turn. First, in light of L. Floridi’s information philosophy and B. Stiegler’s technology philosophy, the philosophical meaning of the current digital technology environment is elucidated. Based on this, it highlights the future of the humanities classics in the broader perspective of the PostHumanities that encompasses the Digital Humanities. According to Floridi, the conditions of human life after the computing and information revolution constitute the Infosphere, in which humans and non-humans form a cooperative network as equal informational entities. Stigler focuses on the algorithmic governmentality inherent in this Infosphere and calls for critical vigilance against the weakening of the human intellect. What role should the classics of the humanities play in a digital environment that is moving toward automation and virtualization of the real world? It must aim to recover the creative mental ability overwhelmed by the automated digital system, to uncover the real problems hidden behind the virtual world, and to prepare a new value and meaning of the life of a posthumanizing “human.” Humanities classics should not be limited to simply revitalizing the spirit of the liberal arts in traditional humanities or used for digitalizing humanities texts, but should contribute to discovering and creating the posthumanity that “we who are becoming” should have by triggering critical reflection and a new understanding of “we humans” standing at a historical turning point.
Dealloying-derived Fe-doped Ni(OH)2/Ni foils as self-supported oxygen evolution reaction catalysts
Authors: Wang Zheng , Li Zhenhan , Chao Yang , Cui Yu , He Xin , Liang Ping , Zhang Chi , Zhang Zhonghua
Published: June 2022

Dealloying has been an essential technique for developing nanostructured catalysts for the oxygen evolution reaction (OER). Self-supported active catalysts can be fabricated through an alloying-dealloying process on metal foil surfaces. This study uses a Ga-assisted alloying-dealloying strategy combined with electrooxidation and heteroatom doping to fabricate a Fe-doped Ni(OH)2/Ni self-supported OER catalyst. We find that the surface phase compositions and dealloyed structures can be adjusted by controlling the reaction-diffusion temperature and time. The optimized O-Ni-Fe/200-3 catalyst shows an overpotential of 318 mV to activate a 10 mA cm-2 current density with a Tafel slope of 60.60 mV dec-1. Ex-situ characterization of the catalyst proves that Fe doping promotes the formation of active NiOOH, which contributes to the excellent OER activity. This study extends the Ga-assisted alloying-dealloying strategy and demonstrates the possibility of controlling the microstructure of dealloyed materials by changing the reaction-diffusion conditions.
Viral Composition in Metagenomes of Rivers Located in the Amazon Mangrove Coast, Northeast of Pará, Brazil
Authors: Monteiro Teixeira Dielle , Sousa Junior Edivaldo Costa , da Silva Luciana Damascena , de Souza Isis Priscila Pereira , Lobato Passinho Fernanda do Socorro , de Moraes Silva Monica Cristina , Teixeira Nunes Marcio Roberto , Monteiro Siqueira Jones Anderson , Resque Hugo Reis , Gabbay Yvone Benchimol
Published: June 2022

In aquatic ecosystems there is a wide variety of viruses, including bacteriophages and others infecting plants, humans and animals. This study aimed to evaluate the viral diversity in surface water samples from three rivers located in the Amazonian mangrove, in higher and lower rainfall period. After concentration by organic flocculation, the viral nucleic acid was extracted by a commercial kit and subjected to the multiplex RT-qPCR and construction of NGS libraries. A total of 47 samples were analyzed and sixty-one different viral families were identified, with the Caudovirales order (Myoviridae, Autographiviridae, Podoviridae and Siphoviridae) being the most representative among the ten most abundant. An increase in the number of viral reads was observed during the lowest rainfall period in the analyzed rivers, with the exception of the Mocajuba river. The families composition was peculiar among the rivers evaluated during the different climatic seasons. Human enteric viruses were not found by both approaches. This study showed the great viral diversity in three different mangroves rivers and the absence of human enteric viruses, a common waterborne-viruses. More studies are needed to elucidate the virus role on the ecology of aquatic ecosystems and the biotic and abiotic impacts on viral diversity and resistance.
Effect of Quercetin Supplementation on Motility of Surti Buck Spermatozoa Preserved at Refrigerated Temperature
Authors: Diniz Wilona V. , C. Modi Lalitkumar , Chaudhari N. F. , Dangar N. S. , Sharma H. C.
Published: June 2022

A study was conducted to examine antioxidant effect of quercetin in tris egg yolk citrate extender on chilling quality of Surti buck semen. Total 72 semen ejaculates from four Surti buck (18 ejaculate/buck) were collected by artificial vagina method twice in a week from each buck upto 9 weeks. Semen samples were diluted with Tris egg yolk citrate extender and quercetin at different concentration viz. C-0 µM, T1-15 µM, T2-25 µM, T3-50 µM, T4-75 µM, T5-100 µM and stored at refrigerated temperature (4-5ºC). Evaluation of semen parameters was done at 0, 24, 36 and 48 hours. The result showed that Addition of 15µM and 25 µM quercetin in tris egg yolk citrate extender maintained motility above 50 % till 36 hours at refrigerated temperature (4-5⁰C).
Soil Fertility Mapping Using GIS in Meghalaya Plateau
Authors: Das Pratibha Thakuria , Lakiang Tangwa , Saikia Bipul
Published: June 2022

Soil fertility maps namely pH, EC, OC, P and K were generated using Geographic Information System from grid wise soil health data collected from SHC Portal. The study revealed that soils of Meghalaya are non saline, acidic in nature and contains high organic carbon. It is found that 69.61% area of the State is covered by slightly acidic soils followed by moderately acidic (27.25%) and strongly acidic (0.09%) soils. Soils of the State is high in organic carbon that covers 88.22% area followed by medium and low that covers 11.52% and 0.26% area. It has also been observed that 69.89% soil of the State is having medium available phosphorus followed by low and high phosphorus content that covers 18.73% and 11.38% area respectively. Soils of the State are low in available potassium that covers 47.35% area whereas medium and high potassium is found in 45.54% and 7.11% area respectively. It is also observed that 98.77% soils of Garo hills are slightly acidic whereas 91.98 % area of Jaintia hills is moderately acidic in nature. Soils of Khasi hills are mostly slightly acidic that covers 68.66% area followed by moderately acidic and neutral soils that covers 24.69% and 6.49% respectively. High organic carbon content is highest in Jaintia Hills that covers 99.45% area followed by 98.90% and 69.64% area in Khasi Hills and Garo Hills respectively.
Evaluation of 4th Generation Elisa HIV Testing Kit and its Comparison with the 3rd Generation Kit
Authors: Sharma Swati
Published: June 2022

The study was organized in the population of Dehradun, Uttarakhand at IMA Blood Bank to ascertain the sensitivity and specificity of 4th generation antibody and antigen p24 combo Elisa kit atop of 3rd generation HIV antibody Elisa kit. Methods: A total of 2045 voluntary donors were screened for HIV over a span of 6 months. The mean age group included 18 to 50 yrs with male preponderance. Each sample was assessed twain with the 3rd and the 4th generation HIV ELISA testing kit of Bio-Rad concomitantly and HIV positive samples were further authenticated with PCR. Results: Out of these 2045 samples, two samples were detected reactive with the 4th generation ELISA kit but nonreactive with the 3rd generation kit. Both these were found to be negative on PCR. One sample was found to be reactive with both 3rd and 4th generation kits and was confirmed positive by PCR. Conclusion: The study does not culminate the precedence of the 4th generation kit atop of the 3rd generation kit. However, we propound that in order to draw a logical conclusion furthermore samples should be evaluated. The study assures that the 3rd generation kit is likewise considerable as the 4th generation ELISA kit, none of the reactive samples (by 4th generation ELISA) was mislaid (by 3rd generation ELISA) which were further authenticated by PCR.
Study of Effect of Crop Establishment Techniques and Seed Rate on Growth and Yield of Direct Seeded Hybrid Rice (Oryza sativa L.)
Authors: Garg Sushmita , Shukla Aditya , Shukla Akanksha , Pandey N.
Published: June 2022

In order to find out suitable crop establishment technique and seed rate for obtaining optimum growth and yield of direct seeded hybrid rice, Arize AZ-8433 DT, an experiment was carried out during kharif 2019 at Instructional-cum-Research Farm IGKV, Raipur, Chhattisgarh in split-plot design with three replications. The crop establishment techniques used as main plot were line sowing with seed priming (M1), line sowing without seed priming (M2), broadcasting with seed priming (M3) and broadcasting without seed priming (M4). Seed priming was done with 1% KCl solution. The seed rate treatments incorporated as sub-plot were 15“kg ha-1 (S1), 20 kg ha-1 (S2), 25 kg ha-1 (S3) and 30 kgha-1 (S4). The seeds primed with 1% KCl and sown in line (M1) recorded the maximum values for emergence percentage, number of total tillers m-2, number of leaves m-2, dry matter m-2, number of effective tillers m-2, panicle weight and number of filled grains panicle-1 which resulted in higher grain yield, straw yield, harvest index, gross return, net returns and B:C ratio. With regard to seed rate, growth parameters were maximum at 30 kg ha-1 (S4) seed rate during initial stages but at later stages, dry matter m-2 was highest under 25 kg ha-1 (S3). However, at all stages, both the seed rate treatments were at par with each other. Panicle weight and number of filled grains panicle-1 were significantly higher under seed rate of 15 kg ha-1 (S1), but still seed rate 25 kg ha-1 (S3) gave highest grain yield due to significantly higher number of effective tillers m-2under it. Straw yield was highest under highest seed rate of 30 kg ha-1 (S4). Seed rate 25 kg ha-1 was optimum for direct seeded hybrid rice as it gave highest gross return, net returns and B:C ratio.
Development of Mobile App for Estimation of Energy Input and Cost Economics of Selected Farm Operations
Authors: dra Gajen , Victor V. M. , Agrawal N.
Published: June 2022

The paper is devoted to the development of an android applications of cost of operation and energy calculation for rice production. It will help to schedule future development by understanding the feasibility of the individual operations and machines involved in those farm operation. Cost of operation contents specify the name of a cost group. “imputed costs” and "variable cost". A function of energy input is the crop yield, it can be applied directly and indirectly. Direct energy is needed to perform different crop-related tasks. The key products for indirect energy help is the energy used in the processing, packaging and transport of fertilizers, crops, machinery and pesticides. The algorithm is a set of words that specify the operation that a variety of rules are intended for the development of an algorithm is a critical step in solving a problem. Algorithm development was carried out in formally and visual able in nature. The algorithm for cost economic and energy inputs in agriculture production is developed to use that as a blueprint for mobile app. The app is an Android-based framework, created using Android Studio, the official Integrated Development Environment (IDE) for the development of Android applications. The aim of work is to create the energy and cost estimation app for farmers that helps analyze energy trends and the cost of various rice cultivation operations. The app named as ECOCAL-farm energy and cost calculator where E stands for energy, CO stands for cost of operation and CAL stands for calculator.
Diagnostic Difficulty in Strongyloides Hyperinfection along with Bateremia -A Case Report
Authors: Priya Venkatachalam , Praveena Raveendran
Published: June 2022

The spectrum of clinical presentation of Strongyloidiasis is wide. From asymptomatic to generalized symptoms can be a presenting feature. This is an endemic disease in tropical and subtropical countries. Still diagnosis can be missed in the earlier stages ending up in hyperinfection which is the dangerous turn of this infection. Since this infection is far wider in prevalence and there is a huge population of diabetic patients there has to be more awareness of this neglected infection. Here we present an interesting case of stongyloides from Chennai, south India who was admitted with Type II Diabetes, Diabetic foot with MRSA bacteremia and later on found out to be a chronic case of strongyloides infection in whom the route of entry of the infection must have been the diabetic ulcer. This case study presents the diagnostic difficulty of strongyloides infection when it coexists rarely with MRSA bacteremia.
Bioprospecting of Actinobacteria in Rhizosphere of Amazonic Soils and Evaluation of Biotechnological Potential for the Production of Antimicrobials - Igarapé-Açu, Pará, Brazil
Authors: da Silva Pinto Lívia Freitas , Santos Caldas Daniel dos , Coelho Prazeres Maria Clara , Emin Uesugi Juliana Hiromi , Cardoso da Silva Jonatan Carlos , Fernandes Caroline Ferreira , Bezerra Nilson Veloso
Published: June 2022

Actinobacteria are important components of the microbial population in most soils and are widely distributed and abundant, especially in the rhizosphere. The phylum Actinobacteria, particularly the genus Streptomyces, is recognized for its potential to produce a vast quantity of secondary metabolites, among which there are bioactive compounds used as antibiotics. The present study sought to isolate and identify actinobacteria from secondary forest rhizosphere in the region of Igarapé-Açu and to evaluate the biotechnological potential of these strains for the production of antimicrobials. Thirty rhizospheric soil samples were collected, pre-treated and seeded on Czapeck Dox and Saboraud Dextrose Agar. The methodology applied consisted of phenotypic analysis, morphological (macroscopic and microscopic) and biochemical characterization. In addition, the isolated strains were submitted to antimicrobial potential evaluation tests in order to verify if they were effective in inhibiting the growth of the multi-resistant pathogenic bacteria Escherichia coli and Klebsiella pneumoniae. We identified 18 strains of actinobacteria with the following presumptive genera: Streptomyces, Nocardia and Actinoplanes. Among the 18 strains, 10 were able to form at least a halo of inhibition against one of the pathogenic bacteria.
Xpert MTB/RIF Assay: An Initial Analysis of Errors, Indeterminate and Invalid Results from Central India
Authors: Panwalkar Nikita , Pauranik Ankur , Sharma Arun Kumar , Mirza Shaina Beg , Ranjan Rajeev , Desikan Prabha
Published: June 2022

Early diagnosis and treatment is the key to successful treatment outcome in patients with tuberculosis (TB). Xpert MTB/RIF assay has greatly reduced the lag time for diagnosis and treatment of TB patients. However, despite the high sensitivity and specificity of the Xpert MTB/RIF assay, test failure can occur due to various reasons. We aim to identify the reasons for errors, indeterminate, invalids and no results that may be useful for initiating corrective measures for Xpert MTB/RIF assay. A total of 1052 smear negative samples, including pulmonary(69.9%) and extra-pulmonary(53.3%) samples were tested using GeneXpert MTB/RIF instrument. In pulmonary samples on initial testing: 3.13% indeterminate, 2.17% no results, 2.17% invalids and 11.7% errors were seen. In extra-pulmonary samples on initial testing 2.52% indeterminates, 1.57% no results, 0.31% invalids and 12.6% errors were seen. The reasons for test failures were identified as inadequate amount or quality of reagent, failed fluid transfer, equipment malfunction, power failures, temperature related errors and errors associated with Xpert-computer communication. Invalid tests were mostly associated with quality of sputum samples. For most of the test failure events, the troubleshooting steps are simple and can be curtailed by collecting good quality sample and scrupulously following the test protocol.
Entomological survey for identification of Aedes larval breeding sites and their distribution in selected rural villages of West and South Tripura, India
Authors: Baidya Subrata , Chander M. Punnam , Karmakar Sanjoy , Paul Bratati , Kalita Biraj
Published: June 2022

The present study aims to identify the breeding sites and distribution of Aedes immature forms in selected tribal villages in West and South Tripura. The survey of aquatic habitats harboring mosquitoes were undertaken in five villages in West Tripura and six villages in South Tripura from September to November 2021. All water-holding containers were inspected for the presence of immature mosquito forms using pipette or dipper net based on container sizes. Adults were counted and observed under a Stereomicroscope following systematic taxonomic keys. A total of 330 immature forms were collected during the study period. Interestingly, no Aedes aegypti was found during the study while, Aedes albopictus was found to be relatively the dominant species in the study area. The house index (HI), container index (CI) and breteau index of West Tripura were 21.6%, 36.6% and 26.4% respectively whereas South Tripura were 20.66%, 33.3% and 26.6% respectively. The present study indicates the dominance of A. albopictus in the rural villages of both West and South Tripura. A considerably larger proportion of artificial productive containers viz. damaged tyres and broken plastic items in the surrounding residential areas highlights the urgency of its reduction efforts. Immediate intervention is required to reduce the water staging in tyres and other products during the cultivation of dragon fruit. This may provide a lucrative alternative for preventing the transmission of dengue and other arboviruses.
Injection Bore Wells are used in the Chittoor Watershed Project to Save Water in an innovative way
Authors: Reddy P. V. R. M. , Janardhan Reddy B. , Ramana Kumar B. V. , Jhansi Rani R.
Published: June 2022

Several developmental paradigms experimented during the India’s post-independence era have indicated that for development to be sustainable it needs to be community based with central focus on inclusiveness, gender equity and in consonance with nature’s laws. This has led to the concept of watershed as a unit for development and philosophy of area development through integrated approach by covering all developmental programmes under different departments into a comprehensive programme for resource conservation and their optimum utilization considering resources on one hand and the demands of all socio-economic classes of people on the other. Injection bore wells are used in the Chittoor Watershed project to save water in an innovative way has been become excellent example in the watershed programme.
General TV Viewing Patterns of Rural School Going Children
Authors: Prasad Deshmukh Jaya Bangale
Published: June 2022

A sample of 150 rural school going children (80 male and 70 female) age ranged between 7-13 yrs were selected by following purposive random sampling method from 6 villages of Parbhani District. The data pertaining to the study were collected by personally interviewing the sample rural school going children based on open ended interview schedule cum checklist after developing rapport with them. Similarly all the sample children’s parents also were interviewed based on the open ended interview schedule cum checklist for obtaining information additionally required for the study. It is clear from the results that relatively a higher percentage of rural school going children (37- 50%) were found to view TV Programmes telecasted on Big Magic channel followed by Channel-2 (28 - 42%) and Channel-3 (24 - 32%). Irrespective of gender, about 98 percent of rural school going children reported that they are more interested in viewing view cartoon serials. More than 70 percent of them had their TV sets in living rooms and a higher percentage of them observed to be maintaining 5-7 ft from TV sets while viewing TV programmes. Irrespective of gender, the findings of the study indicate that significantly a higher percentage of rural school going children (72 – 88%) used to view TV programmes enormously. A higher percent of rural school going children used to view TV programmes by sitting on floor or on cot (47 - 50%). Irrespective of gender, chitchatting (35 - 46%) and eating (38 - 43%) were observed to be the most common concurrently done activities of rural school going children while viewing TV programmes. As compared to the rural school going girls, their counter parts boys used to view TV programmes along with their friends and mothers.
Ecological Analysis of the Parasite Fauna of Valuable and Low-Valuable Fish in the Pond Farms of the Aral Region
Authors: Bauaddinovna Allamuratova Ziyuar
Published: June 2022

The article presents the results of an ecological analysis of the parasite fauna of valuable and low-value fish of the Turtkul pond farm system. At present, there have been significant changes in the ichthyoparasite fauna of the Tuyamuyun reservoir. It has been established that the depletion of the parasite fauna of fish (55 species) is associated with the depletion of the fauna of hydrobions and ecological niches in this region.
Targeted Therapeutic Options and Future Perspectives for HER2-Positive Breast Cancer
Authors: Ferrando-Díez Angelica , Felip Eudald , Pous Anna , Bergamino Sirven Milana , Margelí Mireia
Published: June 2022

Up to 25% of early human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients will relapse despite the improvement achieved by the introduction of HER2-targeted therapy. Beyond trastuzumab, other agents approved for early HER2+ BC include the monoclonal antibody pertuzumab, the antibody-drug conjugate (ADC) trastuzumab-emtansine (T-DM1) and the reversible HER2 inhibitor lapatinib. New agents, such as trastuzumab-deruxtecan or tucatinib in combination with capecitabine and trastuzumab, have also shown an improvement in the metastatic setting. Other therapeutic strategies to overcome treatment resistance have been explored in HER2+ BC, mainly in HER2+ that also overexpress estrogen receptors (ER+). One strategy has been to target the cyclin-dependent kinases 4/6 (CDK4/6) as they are downstream of HER2 and many of the cellular pathways associated with resistance to HER2-targeted therapies play a key role in cell cycle and proliferation. Different trials have explored these strategies with encouraging results, but definitive results are needed. In addition, HER2+ BC is known to be more immunogenic than other BC subgroups, with high variability between tumors. Different immunotherapeutic agents have been investigated in this setting, with promising but controversial results obtained to date.
Keberdayaan Masyarakat Putus Sekolah di Era Ekonomi Kreatif Berbasis Pemberdayaan Masyarakat
Authors: Syaifudin Syaifudin
Published: June 2022

The uncertainty of economic conditions during the Covid-19 pandemic requires humans to survive in all limitations. However, the world of schools is considered to be able to improve the quality of human resources, on the contrary, it is increasingly difficult to access by the community, especially the lower class community. It is proven that every year the dropout rate always increases. Therefore, in order to provide social capital to these out-of-school children, job skills training is needed. With this job skills training, at least the children who drop out of school have the capital to apply for jobs or become entrepreneurs. One of the areas that is part of the children who drop out of school is the RT area. 006, RW. 014 Cengkareng Barat Village, West Jakarta. Because almost 20% of teenagers in this area have dropped out of school, both from elementary, junior high, and high school. Some even don't go to school at all. So it is not surprising that many youths in this region are unemployed. Therefore, in order to minimize the unemployment rate in this region, it is necessary to provide a skill set for these teenagers who drop out of school. So that later they have additional skill capital to apply for jobs or even become their own entrepreneurs.

 

ABSTRAK

Ketidakpastian kondisi ekonomi di masa pandemi Covid-19 menuntut manusia bertahan dalam segala keterbatasan. Akan tetapi dunia sekolah yang di anggap dapat meningkatkan kualitas sumber daya manusia, justru sebaliknya makin sulit di akses oleh masyarakat, khususnya masyarakat kecil kebawah. Terbukti tiap tahunnya angka putus sekolah selalu mengalami kenaikan. Oleh karena itu guna memberikan modal sosial kepada anak yang putus sekolah ini, maka diperlukan pelatihan ketrampilan kerja. Dengan pelatihan ketrampilan kerja ini, setidaknya anak yang putus sekolah itu memiliki modal untuk melamar pekerjaan atau berwirausaha. Salah satu wilayah yang termasuk bagian dari anak yang putus sekolah ini yaitu wilayah RT. 006, RW. 014 Kelurahan Cengkareng Barat, Jakarta Barat. Karena hampir 20% remaja di wilayah ini mengalami putus sekolah, baik dari SD, SMP, maupun SMA. Bahkan ada yang sama sekali tidak sekolah. Maka tidak heran banyak remaja di wilayah ini yang menganggur. Oleh sebab itu untuk meminimalisir tingkat pengangguran di wilayah ini, maka diperlukan sebuah pembekalan ketrampilan bagi para remaja yang putus sekolah ini. Agar nantinya mereka memiliki modal ketrampilan tambahan untuk melamar pekerjaan atau bahkan berwirausaha sendiri.
Pemberdayaan Komunikasi dalam Menumbuhkan Semangat Belajar di Masa Pandemi Covid19
Authors: Sari Wina Puspita , Soegiarto Asep
Published: June 2022

ABSTRAK COVID-19 menyebabkan seluruh aktivitas manusia dibatasi, termasuk kegiatan pembelajaran baik di jenjang sekolah dasar sampai jenjang perkuliahan mulai menerapkan kegiatan belajar dari rumah.  Dari 17 peserta binaan mitra pkm yakni Yayasan Nurul Ihsan, hanya 3 peserta yang menyukai sekolah daring atau online karena waktu yang fleksibel dan bisa dibantu oleh orang tua dan kakak di rumah. sisanya sebanyak 14 peserta mengatakan tidak suka sekolah daring atau online karena pelajaran yang susah dimengerti dan banyak tugas, sisanya berkaitan dengan kuota yang boros, kangen sama guru dan bermain dengan teman. Pada kegiatan pengabdian masyarakat ini, Dosen Prodi D III Hubungan Masyarakat Universitas Negeri Jakarta melakukan sosialisasi pentingnya pemberdayaan komunikasi baik komunikasi interpersonal, komunikasi kelompok dan komunikasi massa untuk mengatasi permasalahan yang dihadapi dalam pemebelajaran daring agar dapat menumbuhkan semangat dan prestasi belajar di masa pandemic.

Kata kunci : Komunikasi Interpersonal, Komunikasi Kelompok, Komunikasi Massa, Semangat Belajar, Pandemi

 

Abstract COVID-19 has caused all human activities to be limited, including learning activities both at the elementary school level to the lecture level, starting to implement learning activities from home. Of the 17 participants assisted by PKM partners, namely the Nurul Ihsan Foundation, only 3 participants liked online schools because their time was flexible and could be helped by their parents and siblings at home. the remaining 14 participants said they did not like online or online schools because the lessons were difficult to understand and there were many assignments, the rest were related to wasteful quotas, missing teachers and playing with friends. In this community service activity, the Lecturer of the D III Public Relations Program at the State University of Jakarta socialized the importance of empowering communication, both interpersonal communication, group communication and mass communication to overcome the problems faced in online learning in order to foster enthusiasm and learning achievement during a pandemic.
Pembuatan Gapura Bhinneka Tunggal Ika Di Kampung Adat Banceuy, Subang, Jawa Barat
Authors: Sumadi Tjipto , Casmana Asep Rudi
Published: June 2022

ABSTRAK

 

Sesuai payung Pengabdian pada Masyarakat Program Studi Pendidikan Pancasila dan Kewarganegaraan FIS UNJ, maka pada awal Agustus tanggal 6 - 8 Agustus 2020, diwujudkanlah kerjasama dengan Pimpinan Desa Adat Banceuy di Subang Jawa Barat. Pengabdian ini dilandasi oleh pemikiran bahwa nilai-nilai luhur masyarakat adat desa Banceuy harus disosialisasikan sepanjang hari kepada generasi muda. Tanggapan masyarakat terhadap program ini sangat baik dan mendukung. Pengabdian pada Masyarakat dengan membuat Gapura Bhinneka Tunggal Ika ini merupakan salah satu cara untuk menjaga dan memelihara nilai-nilai kearifan lokal yang ada di desa adat Banceuy. Gapura Bhinneka Tunggal Ika ini bertuliskan (1) Budaya teh ciri hiji bangsa, wajib dipupusti ku pada bangsa, sangkan teu leungit jati dirina.” dan (2) Kudu ngindung ka waktu, mibapa ka jaman. Bari ulah udar taliparanti ti karuhun, sangkan ajeg adeg budayana.” Keuntungan dari adanya gapura ini adalah seluruh lapisan masyarakat dapat membaca banner yang tertera pada gapura tersebut. Dengan demikian masyarakat dapat diingatkan setiap hari melalui pesan yang ada di gapura ini. Kelemahan pemasangan gapura ini adalah, tiang gapura dibuat dari bambu dengan tali ijuk dan banner dicetak pada plastik, sehingga hanya bertahan sekitar 10 bulan saja. Kesimpulan dari pengabdian pada masyarakat ini dapat dinyatakan bahwa warga desa Adat Banceuy, Subang, Jawa Barat sangat senang dan mendukung pelaksanaan kegiatan ini.
Keterampilan E-Learning guru dan pembelajaran selama pandemi Covid-19; apa masalahnya?
Authors: Samadi Samadi
Published: June 2022

ABSTRAK

Pendidikan seharusnya tidak dipandang sebagai sebuah cara yang terisolasi untuk mengatasi masalah lingkungan termasuk pandemik Covid-19, tetapi lebih sebagai bagian yang kompleks dan beragam dari sistem yang lebih besar dalam struktur dan proses yang saling berinteraksi. Permasalahan belum dimilikinya keterampilan pembelajaran daring oleh sebagian guru geografi merupakan diagnosa awal pentingnya upaya meningkatkan keterampilan e-learning guru sebagai solusi mandiri pembelajaran jarak jauh. Metode kajian menggunakan studi deskriptif. Responden terlibat sebanyak 38 guru dengan pola pengumpulan data melalui data sharing pada platform Google Meet selama Oktober hingga November 2020. Data terolah meliputi deskripsi terkait hasil observasi, hasil desk analysis aspek-aspek permasalahan maupun pengembangan sistem e-learning. Hasil analisis menunjukkan bahwa terdapat tiga komponen penting yang diperlukan guna peningkatan keterampilan e-learning guru yaitu: (1) Metode pelaksanaan dan konten pembelajaran yang lebih cocok; (2) Mainset guru yang baik dalam mensikapi pembelajaran daring; serta (3) Material dan piranti pembelajaran daring yang memadai.

 

ABSTRACT

Education should not be viewed as an isolated way of dealing with environmental problems including the Covid-19 pandemic, but rather as a complex and diverse part of a larger system of interacting structures and processes. The problem of not having online learning skills by some geography teachers is an early diagnosis of the importance of efforts to improve teachers' e-learning skills as an independent solution for distance learning. The study method used a descriptive study. Respondents were involved as many as 38 teachers with a pattern of data collection through data sharing on the Google Meet platform during October to November 2020. The processed data included descriptions related to observations, results of desk analysis of problem aspects as well as e-learning system development. The results of the analysis show that there are three important components needed to improve teachers' e-learning skills, namely: (1) more suitable implementation methods and learning content; (2) A good teacher's mainset in responding to online learning; and (3) adequate online learning materials and tool.
Legal Conundrums of the Metaverse
Authors: Kasiyanto Safari , Kilinc Mustafa R.
Published: June 2022

The metaverse gained its momentum after a CEO of the biggest social media made a statement that it would be the next big thing after the Internet. Although there is no single, agreed definition of the metaverse, the common understanding of the metaverse is that the concept combines IoT, AR, VR, XR, and 3D technologies. It is also called the Web 3.0. The market capital and the economic potential of the metaverse are enormous. The market cap was calculated around USD14.8 trillion in October 2021 while the economic potential ranged from USD3,75 trillion to USD12.5 trillion. Hence, it is of importance to discuss the legal aspects of the metaverse. This article is the first to elaborate the legal conundrums of the metaverse in a more proper manner. It includes discussion on the property law and intellectual property law, and whether the time has come to have “a virtual property law”. It also discusses some other legal aspects such as privacy and data protection, contract law and smart contracts, cybersecurity and cyberattacks, monetary and payment systems laws, and regulation of virtual assets (including securities and commodities laws), tax law, anti-money laundering and KYC, and criminal law. To give a more comprehensive view, some governance and ethical issues of the metaverse are also touched upon.
Recent Progresses on the Pollution Characteristics and Inactivation Approaches of Fungi in Water
Authors: Chen Zhenzhen , Li Guo-Qiang , Xu Hong-Bin
Published: June 2022

Fungi are ubiquitous components of the phylogeny and functional diversity of almost all ecosystems on earth, which are widely distributed in natural and artificial water bodies. People are constantly exposed to fungi. Direct or indirect contact with certain fungi can cause human diseases. In addition, people’s awareness and demand for safe water are gradually increasing in recent years. However, compared with the bacteria that have been widely studied, fungi are less studied, so it is necessary to systematically study the inactivation of fungi. This paper mainly reviews the pollution characteristics of fungi in water and two kinds of fungi inactivation approaches. The first method for fungi inactivation is single disinfectant inactivation, such as chlorine inactivation, chlorine dioxide inactivation, ultraviolet inactivation and ozone inactivation. The second type is combined inactivation, they are advanced oxidation process (AOP) and ultraviolet-chlorine, ozone-chlorine sequential inactivation process. Among all the fungi inactivation pathways mentioned above, AOP and sequential inactivation were better than single disinfectant inactivation. UV and sunlight enhance the inactivating effect of oxidants on fungi by producing hydroxyl radicals. For sequential inactivation, synergistic effect plays an important role. This paper has certain reference significance on how to choose inactivation methods and follow-up fungal inactivation research.
The pan-cancer landscape of crosstalk between chemokinesand the tumor immune microenvironment
Authors: Wuguo， Tian , Lingli Wang , Jianjie， Zhao , Donglin Luo
Published: June 2022

Background
Chemokines are a subfamily of cytokines known for their ability to promote cell migration, particularly that of immune cells. Chemokines are necessary for immune system function and have attracted considerable attention on account of their roles in regulation of the tumor immune microenvironment.
Methods
Chemokine genes were obtained from the TISIDB database, and we examined the correlation, gene alteration, differential expression, and prognostic value of these genes in 33 tumor types based on Cancer Genome Atlas and Genotype-Tissue Expression data. The chemokine score of each sample was calculated using the “ssGSEA” function of the R package “GSVA.” We also evaluated the correlation between chemokine scores and a tumor immune microenvironment index and assessed the influence of chemokine scores on the response of cancer patients to immune checkpoint inhibitor therapy.
Results
We found that tumor samples with high chemokine scores were immune-activated, and further analysis using three immunotherapy cohorts revealed that patients with high chemokine scores were sensitive to anti-PD-1 therapy.
Conclusions
Our results indicate that chemokines are closely associated with the tumor microenvironment, and consequently, patients with high chemokine scores may be suitable for treatment using immune checkpoint inhibitors.
Predicting the most deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) of HRAS gene and in silico evaluation of their structural and functional consequences towards diagnosis and prognosis of cancer
Authors: Chai Chuan-Yu , Sathiya Maran , Afizan Nik Mohd , Cheng Wan-Hee , Loh Jiun-Yan , Lai Kok-Song , Yap Wai-Sum
Published: June 2022

Harvey rat sarcoma (HRAS) protooncogene belongs to the RAS family and is one of the pathogenic genes that cause cancer. Deleterious nsSNPs might have adverse consequences at the protein level. This study aimed to investigate deleterious nsSNPs in the HRAS gene in predicting structural alterations associated with mutants that disrupt normal protein-protein interactions. Functional and structural analysis was em[loyed in analysing the HRAS nsSNPs. Putative post-translational modification sites and the changes in protein-protein interactions, which included a variety of signal cascades, were also investigated. Five different bioinformatics tools predicted 33 nsSNPs as “pathogenic” or “harmful”. Stability analysis predicted shortlisted rs1554885139, rs770492627, rs1589792804, rs730880460, rs104894227, rs104894227 and rs121917759 as unstable. Protein-protein interaction analysis revealed that HRAS as a hub connecting three clusters consisting of 11 proteins and changes in HRAS might cause signal cascades to dissociate. Furthermore, Kaplan Meier bioinformatics analyses indicated that the HRAS gene deregulation affected the overall survival rate of patients with breast cancer, leading to prognostic significance. Thus, based on these analyses, our study suggests that the reported nsSNPs of HRAS may serve as potential targets for different proteomic studies, diagnoses and therapeutic interventions focusing on cancer.
Astragaloside IV alleviates cisplatin-induced nephrotoxicity in Lewis lung carcinoma mice and inhibits the epithelial-mesenchymal transition-mediated invasion and metastasis of lung cancer cells
Authors: Han Xue , Hu Zhi qiang , Chen Han , Wang Ke , Gao Xiao juan , Li Fengmei , Wang Jing
Published: June 2022

Background: the high incidence of nephrotoxicity is a major limiting factor for the clinical use of cisplatin (CDDP), which affects severely the efficacy of chemotherapy. Astragaloside IV (AS-IV) is the characteristic monomer component of Astragalus membranaceus with prominent medical value in fibrosis, inflammation, autoimmune and cardiovascular diseases. However, whether AS-IV is feasible in combination with CDDP to alleviate the nephrotoxicity and the role of AS-IV in preventing the malignant transformation of tumor cells, have not been fully elucidated.Methods and results: this experiment established Lewis lung cancer mouse model through in vivo experiment. From the characteristics of mouse tumor and hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) analysis, kits, TUNEL and other experiments, it was proved that AS-IV could alleviate CDDP-induced nephrotoxicity through activating Nrf2 signaling to reduce the apoptosis of renal tubular epithelial cells and sensitize CDDP to enhance the inhibitory effect of Lewis lung carcinoma.In vitro, through Western blot, Wound healing assay and Transwell assays, we found that AS-IV could inhibit the invasion and metastasis ability of A549 cells via reversing the TNF-α and TGF-β co-stimulated epithelial-mesenchymal transition (EMT) process and down-regulated the expression of NF-κB(p65) synergistically. Conclusion: To sum up, the results of this study show that astragaloside IV reduces the nephrotoxicity of cisplatin induced Lewis lung cancer mice and inhibits the invasion and metastasis of lung cancer cells mediated by epithelial mesenchymal transformation.