bluuebunny/crossref_metadata_2025 huggingface dataset:
Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth
Authors: Dube Collin J , Zhang Ying , Saha Shekhar , Lai Michelle , Gibert Myron Keith , Escalante Miguel , Hudson Kadie , Wong Doris , Marcinkiewicz Pawel , Yener Ulas , Sun Yunan , Xu Esther , Sorot Aditya , Mulcahy Elizabeth , Kefas Benjamin A , Hanif Farina , Guessous Fadilla , Patel Manoj K , Schiff David , Zong Hui , Purow Benjamin W , Holland Eric , Sonkusare Swapnil K , Sontheimer Harald , Abounader Roger
Published: August 2024

Background Glioblastoma (GBM) is the most common primary malignant brain tumor. The aim of this study was to elucidate the role of microenvironment and intrinsic T-type calcium channels (Cav3) in regulating tumor growth and progression. Methods We grafted syngeneic GBM cells into Cav3.2 knockout mice to assess the role of microenvironment T-Type calcium channels on GBM tumor growth. We performed single-cell RNA-seq (scRNA-seq) of tumors from WT and Cav3.2 KO mice to elucidate the regulation of tumors by the microenvironment. We used neurons from WT and Cav3.2 KO mice in co-culture with GBM stem cells (GSC) to assess the effects of Cav3.2 on neuron/GSC synaptic connections and tumor cell growth. Results Cav3.2 KO in the microenvironment led to significant reduction of GBM growth and prolongation of animal survival. scRNA-seq showed that microenvironment Cav3.2 regulates neuronal and glial biological processes. Microenvironment Cav3.2 downregulated numerous genes associated with regulating the OPC cell state in GBM tumors such as SOX10 and Olig2. Neuronal Cav3.2 promoted neuron/GSC synaptic connections and GSC growth. Treatment of GSCs with the Cav3 blocker mibefradil downregulated genes associated with neuronal processes. The Cav3 blocker drug mibefradil synergized with temozolomide (TMZ) and radiation to reduce in vivo tumor growth and prolong animal survival. Conclusions Together these data reveal a role for microenvironment Cav3 in promoting GBM tumor progression through regulating neuronal and glial processes particularly associated with the OPC-cell state. Targeting both intrinsic and microenvironment Cav3 with the inhibitor mibefradil significantly enhanced the anti-GBM effects of TMZ and radiation.
Odoribacter splanchnicusmitigatesSalmonella-induced gut inflammation and its associated pathogenesis via its secreted bacteriocin
Authors: Hajra Dipasree , Mukherjee Debapriya , Vij Rhea , Rajmani Raju S , Dadireddy Venkatareddy , Das Deepakash , Husain Tanweer , Ganji Mahipal , Tatu Utpal , Chakravortty D
Published: August 2024

Foodborne pathogens continue to be a leading concern of health hazards worldwide claiming the lives of millions. The emergence of drug-resistant strains poses a great threat to global world health management. Therefore, designing novel therapeutic strategies aiming to overcome pathogen burden is of utmost importance. Here, we identified the crucial role of a gut-commensal species,Odoribacter splanchnicusin mitigatingSalmonellapathogenesis in mice by inhibiting gut vascular barrier disruption, acute inflammatory infection signs,in vivobiofilm formation and by preserving tight junction protein functions upon pre-colonization. Further, ourin vitrostudies revealed that not only liveO. splanchnicus(OS) but also its culture supernatant inhibitSalmonellabiofilm formation, intracellular proliferation in human intestinal cells, and its virulence gene expression. In addition, OS’s inhibitory effect onSalmonellais specific asEnterococcus faecalisfails to exert an inhibitory effect onSalmonella. Further, our results depicted that the specific protective role of OS acts over a broad spectrum as it confers protection against flagellated Gram-positive,Listeria monocytogenesand Gram-negative,SalmonellaTyphimurium foodborne pathogens, as opposed to non-flagellatedShigella flexneri. Moreover, OS conferred protection even after its administration to mice post-establishment of infection highlighting its therapeutic potential. Using several biochemical and proteomics approaches, we characterized the key active molecule secreted by OS to limit intracellularSalmonellaandListeriareplication in human intestinal epithelial cells by regulating key virulence effectors and flagella. Collectively, our study highlights the broad-spectrum protective role of OS in mitigatingSalmonellaandListeriapathogenesis and implicates its therapeutic potential.
The nexus of stewardship and sustainability in supply chains: revealing the impact of purchasing social responsibility on innovativeness and operation performance
Authors: Zouari Dorsaf , Viale Laurence , Ruel Salomée , Stek Klaas
Published: August 2024

Purpose

The authors mobilise stewardship theory, which delves into trust and collaboration dynamics, advocating for long-term gains through actions beneficial to the broader community. Used as a fundamental framework to conceptualise the model, stewardship theory enhances the understanding of the effect of purchasing social responsibility (PSR) practices to foster innovativeness and performance through the supply chain (SC). This study aims to examine the relationship between PSR, SC innovativeness (SC-INNO) and SC operational performance (SCOP). In addition, the moderating effect of sustainability labels on these relationships will be studied.

Design/methodology/approach

Based on survey data from 177 organisations analysed through partial least square structural equation modelling, the results suggest that PSR has a positive and significant effect on SC-INNO and SCOP. In addition, SC-INNO plays a partial mediation role since the direct effect between PSR and SCOP is validated. Furthermore, the moderating effects of holding a sustainability label and industry type about PSR and SCOP are supported.

Findings

The results indicate a significant positive influence of PSR on both SC-INNO and operational performance. SC-INNO is found to partially mediate the PSR–SCOP relationship. Moreover, sustainability labels and industry type significantly moderate the effects of PSR on SCOP.

Originality/value

The findings extend stewardship theory into the sustainable purchasing and supply management field by providing empirical support for PSR as a reflection of stewardship behaviours by fostering innovation and performance throughout the SC.
Evaluating the critical resultant impacts of the COVID-19 pandemic on quality assurance of cross-border construction logistics and supply chain
Authors: Ghansah Frank Ato , Lu Weisheng
Published: August 2024

Purpose

This study aims to identify and examine the critical resultant impacts of the coronavirus (COVID-19) pandemic on quality assurance (QA) of cross-border construction logistics and supply chain (CB-CLSC).

Design/methodology/approach

This is achieved via embedded mixed-method design pragmatically involving desk literature review, survey and interviews from related experts within the Hong Kong Special Administrative Region (SAR)–Mainland China links. The design is further integrated with descriptive analysis, criticality test, rank agreement analysis, spearman correlation test and sentiment analysis.

Findings

The study revealed 10 critical resultant impacts of the COVID-19 pandemic on the QA of CB-CLSC, with the top three including “increased use of digital technologies (M10)”, “worker absence, labour shortage and decrease in work rate (M3)” and “changes to how construction sites operate (M9)”. Three underlying dimensions were discovered among all the critical resultant impacts: “cost-time-worker (CTW)-related impacts”, “work contract and operation (WCO)-related impacts” and “work process (WP)-related impacts”. The critical resultant impacts are reflected in the time, cost, raw materials and work processes, and this could manifest as negative as well as an opportunity to position the QA system to be adequate during the pandemic and post-pandemic era.

Originality/value

The study contributes to the knowledge body as it identifies and examines the critical resultant impacts of the COVID-19 pandemic on the QA of CB-CLSC. This is original research with invaluable primary data collected in the form of surveys and interviews from construction quality experts within the Hong Kong (SAR)–Mainland China links, known as the world’s factory.
Strategies for improving project risk management via communication and integration: the case of Jordan
Authors: Hatamleh Muhammad T. , Alzarrad Ammar , Alghossoon Abdullah , Alhusban Mohammad , Ogunrinde Olugbenro
Published: August 2024

Purpose

Project information is widely and thoroughly exchanged within construction projects. However, the risk management process exhibits deficiencies in coordination and visibility, particularly in developing countries. Practitioners in developing countries often engage in Project Risk Management (PRiM) using practices that inadvertently hinder project success, frequently resulting in suboptimal outcomes. Therefore, this research explores practices within Project Integration Management (PIM) and Project Communication Management (PCmM) that could enhance PRiM and improve managerial proficiency to achieve project success in developing countries.

Design/methodology/approach

The PIM, PCmM and PRiM processes were explored from the literature; the data was gathered initially by close-ended interviews conducted with a panel of twelve experts followed by a well-structured questionnaire. Structural Equation Modeling (SEM) was employed via AMOS to analyze the data and construct a model representing the intricate relationships between the processes. Additionally, the validity and reliability of the method were inspected.

Findings

The data analysis confirmed that PIM and PCmM were correlated according to contractors and consultants in the Jordanian construction industry. Furthermore, both have a positive influence on the PRiM. In addition, a 13-step process was developed to apply extra processes and practices to ensure better implementation of the PRiM in developing countries.

Originality/value

The literature highlights that integration and communication management influence project performance. However, there is a lack of research utilizing practices from these knowledge areas to achieve better project risk management implementation. This research highlights two of the most underrated knowledge areas in project management. Therefore, a framework was devised, comprising processes that practitioners should take into account during the planning phase leading to efficient PRiM to enhance their managerial proficiency.
Uniqlo in Russia: market exit dilemma in an international market
Authors: Singh Harvinder
Published: August 2024

Learning outcomes

After completion of the case study, students will be able to: 1. understand the basis for developing global supply chains for exploring international markets, 2. identify the various sources of geopolitical risk while expanding globally, 3. assess the market entry or exit decisions from a principled and commercial perspective and 4. identify and weigh different options when faced with an exit situation under conditions of geopolitical risk.

Case overview/synopsis

The Japanese fast fashion brand Uniqlo opened 45 stores in Russia as a part of its international retail expansion strategy. The brand provided affordable fashion for everyone. However, the Russia–Ukraine armed conflict had put the company in a dilemma. The Japanese Government and the public joined the broader global community in condemning Russia’s armed intervention in Ukraine. These countries also imposed economic sanctions on Russia, resulting in many multinational companies winding up their operations in Russia. Uniqlo faced a market exit dilemma. Russia had the largest number of Uniqlo stores in Europe. The company CEO also highlighted the necessity of meeting the clothing needs of the Russian people. However, people in Japan and elsewhere considered Russia as an aggressor nation. Any economic link with the Russian market would be ethically wrong, and consumers in Japan, the USA and the European Union might see this as support for Russia’s war efforts. The company had to choose between continuing operations in Russia or exiting the Russian market.

Complexity academic level

This case study can be used in basic marketing management and international business courses to discuss the market attractiveness and risk aspects for market entry or exit decisions. It can also be used in advanced courses such as strategic management, global strategy and global political economy, highlighting the impact of geopolitical conflicts on business operations.

Supplementary materials

Teaching notes are available for educators only.

Subject code

CSS 11: Strategy.
Effects of green human resource management practices on employee green behavior: the role of employee’s environmental knowledge management and green self-efficacy for greening workplace
Authors: Miah Masum , Rahman S.M. Mahbubur , Biswas Subarna , Szabó-Szentgróti Gábor , Walter Virág
Published: August 2024

Purpose

This study aims to examine the direct effects of Green Human Resource Management (GHRM) practices on employee green behavior (EGB) in the university setting in Bangladesh and to find the indirect effects of how GHRM promotes EGB through sequentially mediating employee environmental knowledge management (EEKM) (environmental knowledge and knowledge sharing) and green self-efficacy (GSE).

Design/methodology/approach

For the empirical study, the researcher uses partial least squares structural equation modeling to test the proposed conceptual model built on existing literature for greening workplaces in the university in Bangladesh. The study has collected data from 288 Bangladeshi university employees using convenient sampling.

Findings

The findings that GHRM practices positively and significantly promote EGB, which captures the employee's tendencies to exercise green behavior in daily routine activities such as turning off lights, air conditioning, computers and equipment after working hours, printing on both sides, recycling (reducing, repair, reuse), disseminating good green ideas, concepts, digital skills and knowledge to peers and champion green initiatives at work. Moreover, the findings also revealed the sequential mediation of EEKM (environmental knowledge and knowledge sharing) and GSE of employees between the link GHRM and EGB. At last, the findings suggested that HR managers can implement the GHRM practices to promote green behaviors among the academic and non-academic staff of the university.

Originality/value

This study contributes to the field by extending knowledge of Social Cognition Theory and Social Learning Theory for greening workplaces in Bangladesh, particularly universities. Specifically, this empirical study is unique to the best of our knowledge and highlights the role of EEKM and GSE as mediation between GHRM and EGB association.
The impact of macroeconomic policy and supply shocks on sectoral output and the implications for policy
Authors: Ahiadorme Johnson Worlanyo , Akoto Linda
Published: August 2024

Purpose

Little is known about the quantitative impact of macro policies on disaggregated variables. This study investigates the effects of macroeconomic policies and cost/supply shocks on sectoral output growth.

Design/methodology/approach

We analyzed empirical evidence from Ghana using a Structural Vector Autoregression approach.

Findings

The results show that the transmission of various macro policies and supply/cost shocks is conditional on sectoral idiosyncrasies. Fiscal programs contribute the most to agricultural output growth and the least to industrial production. The downturn from rising costs and supply disruptions is more severe and lasting in the agriculture sector than in the service sector. The evidence shows that fiscal consolidation centered on government consumption cuts would not drag growth over the medium-term.

Practical implications

Our results show that the structural characteristics of a country may play an important role in understanding the output effects of macro policy changes. The empirical evidence shows that targeted policies are needed to complement countercyclical macroeconomic policies to facilitate broad-based economic recovery.

Originality/value

Research on the impact of macro policy shocks on the real economy has usually focused on the behavior of highly aggregated variables. In this research, we focus on disaggregated, sector-level variables to unveil the idiosyncrasies in the performance of disaggregated variables that are usually concealed when studying the behavior of aggregate variables. This study also contributes a different angle to the debate on supply shocks by examining how cost shocks are propagated through the various sectors of the economy.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-11-2023-0876
Developments in robotic teleoperation
Authors: Bogue Rob
Published: August 2024

Purpose

The aim of this article is to provide details of recent technological developments in robotic teleoperation.

Design/methodology/approach

Following a short introduction, the two main sections of this article provide examples of recent research involving the application of virtual reality and haptic technologies, respectively, to robotic teleoperation. Brief conclusions are drawn.

Findings

Teleoperation systems are being developed which incorporate virtual reality and haptic feedback technologies. Those using virtual reality seek to enhance the operator’s feeling of immersion in the scene and improve their situation awareness and trials involving diverse tasks illustrate that the technology can achieve these aims and overcome many limitations of traditional systems. Haptic feedback further enhances the degree of operator involvement and control and is now being adopted in commercial minimally invasive surgical systems. Systems which combine virtual reality with haptic feedback are being developed and have the potential to allow operators to conduct increasingly complex tasks.

Originality/value

Through reference to recent research, this illustrates how virtual reality and haptic technologies are enhancing the capabilities of robotic teleoperation.
Enhancing resilience: model-based simulations
Authors: Kancs d'Artis
Published: August 2024

Purpose

In light of the recently experienced systemic shocks (the COVID-19 pandemic and the war in Ukraine), we investigate supply chain robustness. We aim to understand the potential consequences of uncertain events or adversary’s action on critical supplies in the Alliance.

Design/methodology/approach

We leverage a parsimonious supply chain model and investigate the relationship between upstream supplier concentration/diversification and the supply chain’s robustness (survival probability) in the presence of uncertain systemic shocks. In several scenarios of shock events, we simulate alternative input sourcing strategies in the presence of uncertainty.

Findings

A firm-level cost-focused optimisation may lead all upstream suppliers to concentrate in one location, which – when subsequently hit by a shock – would result in a disruption of the entire supply chain. A chain-level forward-looking optimisation diversifies the upstream supplier location and sourcing decisions. As a result, the supply chain’s survival probability is maximised, and critical supplies will continue even under the most demanding circumstances.

Research limitations/implications

Our findings encourage political and military decision makers to enhance upstream supply chain robustness in critical and strategic sectors, such as the diversification of nitrocellulose supplies currently sourced almost exclusively from China by European gunpowder manufacturers.

Practical implications

Our findings have direct recommendations to supply chain downstream decision makers and to the government’s policy choices. Since global supply chain (GSC) disruptions in critical sectors may have catastrophic impacts on social welfare and the probability of shocks such as COVID-19 and Russia’s war may not be known even approximately, robust decision rules seem to be the appropriate tools for policymaking in critical and strategic sectors such as energy supplies, food and water, communication and defence. A robust supply chain is one in which the survival probability is maximised, which we show in a central planner strategy’s simulations.

Originality/value

The paper shows formally why a market-based global input sourcing strategy may be efficient from an individual firm’s perspective but may be suboptimal from a societal resilience perspective.
The “active struggle” of the hybrid middle manager: exploring the notion of ethical resistance
Authors: Conroy Mervyn , Kempster Steve , Remke Robyn
Published: August 2024

Purpose

This paper brings attention to the role of hybrid middle managers. In particular it explores the relationship of organisational purpose and role requirements.

Design/methodology/approach

The primary research question for the original research was: What does it mean to hybrid managers to lead and deal with imposed changes (restructuring) to services? A novel narrative approach based on a synthesis of Czarniawska, Gabriel and Boje was applied. Accounts from interviews were condensed into narratives by initially using the categories defined by Gabriel (2000) as epic, tragic, comic and romantic and then further categorised into stories, themes and a serial (Czarniawska, 1997). The final stage of the three-way synthesised narrative approach incorporated Boje’s (2001) notion of “antenarrative” to include pre-emplotment elements.

Findings

Four narratives are provided that give insight to the nature of the struggles the hybrid middle managers were in the midst of. A struggle to address incongruent demands being placed on them that cause tension with their sense of purpose, organisational goals and their hybrid clinical roles and management roles. In the midst of these struggles the narratives illustrate the dynamic of ethical resistance that seeks a way forward. However, this appears to come at a health and well-being cost to the middle managers.

Originality/value

The paper offers up the notion of an added third bind to the traditional double, that of “ethical resistance”, a struggle to align organisational purpose with clinical and management role requirements. Theorising this third bind provides a new insight into understanding the context and dynamics of the hybrid middle manager role and behaviour. Indeed, the idea of ethical resistance may cause a revision of how resistance is understood.
Assessing the impact of emotional distress on internet gaming disorder among youth in Bangladesh: a cross-sectional survey
Authors: Muyeed Abdul , Talukder Anup , Rahman Ratul , Rumi Maruf Hasan
Published: August 2024

Purpose

As technology becomes more widely accessible, there is a growing concern about internet gaming disorder (IGD) around the world. The aim of this study is to evaluate the prevalence of IGD and also assess the effects of depression, anxiety, stress and insomnia levels on the IGD of youths in Bangladesh.

Design/methodology/approach

A cross-sectional quantitative study design was used to collect data from the youths of different locations in Bangladesh between October 21, 2023 and January 15, 2024. A total of 501 samples were collected using the convenience sampling technique. The following measurement scales were Internet Gaming Disorder Scale short form, depression, anxiety and stress scales and insomnia severity index, which were used to assess scores for IGD, psychological distress and insomnia, respectively.

Findings

The study found that the prevalence of IGD was 9.8%. IGD was shown to be significantly associated with depression, anxiety and stress. Aside from that, IGD and insomnia had a significant association, as did a friendly family environment.

Research limitations/implications

The generalizability of the results could be improved by conducting additional studies with a more diverse sample, such as the general population or a different age group.

Practical implications

The study will help the government reduce the prevalence of IGD, improving the mental and physical health of youth.

Originality/value

No research has been conducted on youth and different professions in Bangladesh. There has also been very little research on the prevalence of gaming addiction and mental health.
Stakeholders’ involvement in economics and management programs quality assurance
Authors: Mazza Tatiana , Azzali Stefano
Published: August 2024

Purpose

This study aims to investigate the stakeholders’ (employers and students) involvement in economics and management programs quality assurance in Italian universities from the external audit perspective.

Design/methodology/approach

The research tests if employers are positively associated with the coherence between program objectives and job prospects, and if student involvement is positively associated with student orientation, tutorship and flexibility for specific types of students (differently abled students and working students). Based on data from the Italian Agency for Quality Assurance (ANVUR) in Italian universities, this study selects a sample of 44 bachelor and master university programs.

Findings

When a program coordinator assures coherence between competencies included in the study plan and job prospect, the employers’ involvement in the plan and management of the program increases and becomes more effective. High-quality services regarding student orientation, tutorship and flexibility for specific types of students increase the students’ involvement in university governance.

Originality/value

Findings contribute to literature extending the stakeholder theory in universities, better specifying how employers and students may play a key role in improving the quality assurance of teaching activities.
Employees’ intrinsic motivation in mediating the relationship between perceived ambidextrous organizational culture and innovative behaviour in the Indian IT sector
Authors: Kandoth Sneha , Shekhar Suraj Kushe
Published: August 2024

Purpose

This paper aims to examine the mediating role of employees’ intrinsic motivation in the relationship between perceived ambidextrous organizational culture and innovative behaviour among information technology (IT) sector employees.

Design/methodology/approach

The study used a quantitative research methodology, using a questionnaire to gather data from a sample of 510 employees across a range of IT organizations and various roles in the Indian IT sector. Smart partial least squares structural equation modeling Version 3 was used for the analysis and interpretation of the study.

Findings

The findings revealed a significant positive relationship between perceived ambidextrous organizational culture and employees’ innovative behaviour in the Indian IT sector. Moreover, the study established that employees’ intrinsic motivation played a significant mediating role in this relationship.

Originality/value

This study stands out for its exploration into how employees’ intrinsic motivation mediates the relationship between ambidextrous organizational culture and innovative behaviour. It offers valuable insights for enhancing organizational creativity by understanding the critical role of intrinsic motivation.
Contesting women’s history in cultural and heritage tourism: a horizon 2050 paper
Authors: Khoo Catheryn , Guan Xinhua
Published: August 2024

Purpose

The purpose of this paper is to critically examine and address the historical gender biases within heritage tourism, particularly focusing on the marginalisation of women’s narratives, and subsequently, to advocate for a more inclusive and gender-neutral approach in both the interpretation and management of cultural and heritage tourism.

Design/methodology/approach

Rather than adhering strictly to one methodological tradition, the pragmatist framework for this study involves a cursory review of extant academic literature pertaining to the historical representation of women in heritage tourism. Since pragmatism acknowledges that theories are context-dependent, the review is coupled with a discerning reflection on our own extensive body of work spanning the last 15 years, particularly focusing on gender dynamics and women’s roles within the broader context of tourism studies.

Findings

Findings advocate for investigating the use of women’s histories to foster diversity in cultural heritage and heritage tourism; highlighting marginalised indigenous and migrant women; examining the impact of inclusivity changes on urban spatial practices; and advancing historical methodologies for non-Anglo women’s histories in heritage tourism.

Originality/value

The paper underscores a positive shift in the tourism academy towards recognising diversity in research and, in line with this, contributes to a prospective research agenda that advocates for the nuanced exploration of women’s histories in the promotion of diversity and inclusivity in cultural heritage and heritage tourism management.
Sport event research in the hospitality and tourism industry: a bibliometric analysis
Authors: Yüksel Faruk , Ön Funda
Published: August 2024

Purpose

This study examines the international literature on sports events published between 1981 and 2024 within the framework of specific parameters.

Design/methodology/approach

The data were analyzed using quantitative and bibliometric analyses. Studies related to sports events were scanned through the Scopus database, and 1,072 studies were evaluated.

Findings

It has been revealed that the highest number of studies related to sports events were published in 2021, with Tichaawa, T.M. being the author with the most publications. Griffith University conducted the most studies on this topic, and the United States had the highest number of publications. Additionally, the findings indicate that the number of studies on sports events is increasing, with more studies being conducted in business and social sciences. Regarding keyword usage frequency, the studies focus on destination image, economic impact, and sustainability. Clustering analysis results show that the studies are divided into four clusters, focusing on sports, tourism, and tourism development.

Research limitations/implications

Due to methodological limitations, the results of bibliometric analysis generally focus on metrics related to articles, sources, and authors. Another limitation is the examination of studies in the context of tourism that are published in the international literature and accessible only through the Scopus database in English. An additional limitation is that the publications analyzed in this study are specifically on sports events. This study aims to fill a gap in the field by examining sports event studies in the international literature, thereby providing researchers with a holistic perspective. It is considered significant as it will offer a different viewpoint on bibliometric studies related to sports events and sports tourism in the international literature, both in terms of the parameters used in the study and the study’s focus.

Originality/value

It is believed to be important because it is the first bibliometric study explicitly conducted on sports events.
The coloniality of age: Navigating the chronopolitics of Black childhood
Authors: Stewart Callum
Published: August 2024

For Black, Indigenous, and other colonised peoples, decolonisation and racial justice are urgent imperatives, but their demands are often dismissed as utopian, impossible, or otherwise out‐of‐time. This article therefore introduces the coloniality of age as a theoretical framework that aims to open up possibilities for otherwise worlds. Departing from established accounts of the coloniality of time, the coloniality of age grounds the analysis of racialised time in the chronopolitical formations of tempus nullius and the paternalistic paradigm. Alongside the doctrine of terra nullius or ‘uninhabited land’, the doctrine of tempus nullius or ‘uninhabited time’ works to deny Black peoples the ability to make and remake history on their own terms. Supplementing theories of the barbarian other, the paternalistic paradigm identifies patriarchal father/child relations as a conceptual and historical precedent to race. The coloniality of age directs the analysis to the temporal limits of coloniality. I argue that the temporal limits of coloniality are constituted by Black childhood; the coloniality of age figures Black childhood as an age with no future. This framework is then applied to analyse young Black peoples' counter‐narratives of Black childhood. The counter‐narratives of being ‘stuck’, ‘growing up’, the ‘pace’ of racism, and ‘regressing’ centre the temporal agency of Black children as they navigate the chronopolitics of Black childhood. Each of these counter‐narratives unsettles the coloniality of age. Read together, the counter‐narratives tell a larger story of Black children confronting the temporal limits of coloniality, refusing the terms of White futurity, and instead opting to grow otherwise. The article concludes that Black childhood might be reframed as an age with otherwise futures beyond the temporal limits of coloniality.
Use of statement validity analysis in minors alleging sexual assault: A systematic review
Authors: Wouters Emilie , Constanty Lauriane , Urben Sébastien , Amoussou Joëlle Rosselet , Gasser Jacques
Published: August 2024

This systematic review aims to report on the use of Statement Validity Analysis (SVA) with minors involved in criminal justice proceedings. We conducted a literature search of six bibliographic databases up to March 2024. Additional searches were performed using citation tracing strategies. Nineteen studies published between 1991 and 2023 were retained. Most were published between 1991 and 2000, mainly in the USA. A scientific gap was observed for 10 years before studies resumed between 2011 and 2022. These 19 studies involved 2931 children; most were girls (n = 2080; 71%). The mean age was 9.4 years (SD = 2.40; min = 2; max = 17.5). Most studies did not mention the nature of the relationship between the child and the alleged perpetrator of sexual violence, three studies involved intra‐family violence and six studies involved victims of intra‐ and extra‐family violence. Nearly 75% of the interviewers were trained with SVA methods. Most were mental health professionals (52.6%) or police officers (15.8%). No study used the SVA as a whole, 10 studies used 19 criteria of the Criteria‐Based Content Analysis (CBCA), and no study used the Validity Check List (VCL). Most studies performed SVA on interview transcripts (n = 8), and two studies performed their analysis on both verbatims and video. The conclusion of our literature review highlights the methodological weaknesses of these studies and encourages more research about the use of SVA in the judicial field to reduce the risk of misleading the judiciary.
Hot air–assisted radio frequency drying of orange slices: Drying behavior and product quality
Authors: Ismail Mohammed , Özbek Hatice Neval , Göğüş Fahrettin
Published: August 2024

This research aimed to assess the hot air–assisted radio frequency drying (HA‐RFD) of orange slices to evaluate the possibility of producing high‐quality dried orange slices and overcome the problem of the long drying time and the high energy consumption. The effect of electrode distance (60, 70, and 80 mm) and number of slices (1–3 slices; 4 mm thickness per slice) on the HA‐RFD of orange slices was evaluated. Orange slices in three layers with a total thickness of 12 mm and an electrode gap of 70 mm were picked to dry the orange slices in the shortest time. The quality of orange slices dried with HA‐RFD was compared with those of HA‐dried (HAD) and freeze‐dried (FD) samples. HA‐RFD allowed a 67% decrease in the time of drying of the orange slices (from 1170 to 390 min) when compared to HAD. Total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, and color values were affected by the drying technique. HA‐RFD showed higher TPC, TFC, and antioxidant activity than HAD. The FD samples showed the highest TPC (928 mg GAE/100 g dw), TFC (200 mg rutin/100 g dw), and antioxidant activity (67.58%). Moreover, the samples dried with HA‐RFD resulted in the least color change in comparison to HAD and FD samples. Regarding vitamin C, FD samples were the best, followed by HA‐RFD and HAD, respectively. Considering the final product quality, and the characteristics of drying techniques, especially drying time and drying rate, HA‐RFD proved to be an alternative technique to the HAD for producing dried orange slices.

Practical Application

HA‐RFD was applied for the first time as an alternative technology to dry orange slices. The quality of orange samples dried by HA‐RFD was compared with samples that dried by HAD and FD. The results indicated that the HA‐RFD technique is a good method to dry orange slices by considering the drying characteristics and the final product quality.
Nursing diagnoses related to cardiovascular function in primary care: A scoping review
Authors: Cruz Neto João , de Oliveira Lopes Marcos Venícios
Published: August 2024

Objective

To map nursing diagnoses related to cardiovascular function reported in studies involving patients in primary care.

Method

A scoping review follows JBI guidelines. Literature searches were conducted from March to May 2024. Studies included focused on nursing diagnoses for adults and older adult patients with cardiovascular conditions in primary care settings. Results were systematically presented in tables and narratively.

Findings

Among the 12 included studies, the most prevalent diagnosis was “noncompliance” (00079), removed from NANDA‐I in 2017. Sixteen other diagnoses were identified, indicating a broader clinical profile of individuals with cardiovascular health issues in primary care. Most studies involved patients with hypertension in Brazil.

Conclusions

Key nursing diagnoses for patients with cardiovascular conditions in primary care were identified. Ineffective health management emerged as a common characteristic among this population.

Implications for nursing practice

Identifying prevalent diagnoses allows nurses to reinforce their commitment to managing cardiovascular conditions, improve care plans, and generate practice indicators for services, thus enhancing the quality of care provided.
Tretinoin synergistically enhances the antitumor effect of combined BRAF, MEK, and EGFR inhibition in BRAFV600E colorectal cancer
Authors: Yoshida Yuya , Takahashi Masanobu , Taniguchi Sakura , Numakura Ryunosuke , Komine Keigo , Ishioka Chikashi
Published: August 2024

Patients with BRAF‐mutated colorectal cancer (BRAFV600E CRC) are currently treated with a combination of BRAF inhibitor and anti‐EGFR antibody with or without MEK inhibitor. A fundamental problem in treating patients with BRAFV600E CRC is intrinsic and/or acquired resistance to this combination therapy. By screening 78 compounds, we identified tretinoin, a retinoid, as a compound that synergistically enhances the antiproliferative effect of a combination of BRAF inhibition and MEK inhibition with or without EGFR inhibition on BRAFV600E CRC cells. This synergistic effect was also exerted by other retinoids. Tretinoin, added to BRAF inhibitor and MEK inhibitor, upregulated PARP, BAK, and p‐H2AX. When either RARα or RXRα was silenced, the increase in cleaved PARP expression by the addition of TRE to ENC/BIN or ENC/BIN/CET was canceled. Our results suggest that the mechanism of the synergistic antiproliferative effect involves modulation of the Bcl‐2 family and the DNA damage response that affects apoptotic pathways, and this synergistic effect is induced by RARα‐ or RXRα‐mediated apoptosis. Tretinoin also enhanced the antitumor effect of a combination of the BRAF inhibitor and anti‐EGFR antibody with or without MEK inhibitor in a BRAFV600E CRC xenograft mouse model. Our data provide a rationale for developing retinoids as a new combination agent to overcome resistance to the combination therapy for patients with BRAFV600E CRC.
Alantolactone facilitates ferroptosis in non‐small cell lung cancer through promoting FTH1 ubiquitination and degradation
Authors: Huang Yijiao , Xiang Pei , Chen Yuanyuan , Pan Qi , Yuan Kemiao
Published: August 2024

Alantolactone (ALT), a natural sesquiterpene lactone from Inula helenium L., demonstrates potent antitumor activity in various human cancers, notably non‐small cell lung cancer (NSCLC). Despite its recognized efficacy, the precise mechanisms of action remain elusive. Our study aimed to elucidate ALT's impact on NSCLC. Our findings suggested that ALT triggered apoptosis both in vitro and in vivo, underscoring its anticancer potential. Interestingly, the ferroptosis inhibitor (Fer‐1), rather than necrostatin‐1 (Nec‐1) or Z‐VAD‐FMK, rescued ALT‐induced cell death, implicating ferroptosis as pivotal. Subsequent analyses revealed ferroptosis as the primary mechanism underlying ALT‐induced NSCLC cell death, supported by markers including ROS accumulation, MDA elevation, GSH depletion, Fe2+ generation, and GPX4 reduction. Through DARTS/MS proteomics, we identified FTH1 as the target of ALT‐induced ferroptosis. Immunoblotting confirmed ALT's inhibition of FTH1 protein expression and accelerated its degradation in NSCLC cells. Immunoprecipitation assays demonstrated increased FTH1 ubiquitination induced by ALT. Additionally, ALT induced ferroptosis and facilitated Fe2+ accumulation via FTH1 ubiquitination. Importantly, ALT displayed potent antitumor effects in a subcutaneous xenograft model in BALB/c‐nu/nu nude mice by enhancing ferroptosis. In summary, ALT induced ferroptosis by promoting intracellular Fe2+ accumulation through accelerated FTH1 degradation, highlighting its potential as an antitumor agent targeting ferroptosis.
‘Devoted Despite It All’: Norwegian Child Welfare Workers' Experiences of Implementing a Therapeutic Model for Adolescents With Co‐Occurring Problems
Authors: Kvamme Line Solheim , Waaler Pamela M. , Helland Siri Saugestad , Mellblom Anneli Viktoria , Ness Ottar
Published: August 2024

In Norway, child welfare responsibilities are divided between state‐run (SCW) and municipal (MCW) agencies. This study explores MCW practitioners' experiences of implementing a therapeutic model tailored by SCW for MCW to aid adolescents with severe and co‐occurring problems and their families. In this qualitative study, 12 MCW practitioners participated in semistructured interviews about the implementability of the therapeutic model. The interviews were transcribed verbatim and analysed using reflexive thematic analysis. The codebook approach Framework Analysis was used to develop codes, initial themes and final themes through several iterations. Each theme was reviewed for convergence and divergence, across interviews. Practitioners' responses to the Intervention Usability Scale were used to supplement our analysis. Five themes emerged as follows: (1) Internal Motivation: practitioners were driven by the desire to do good; (2) Finally, We Have Something to Offer: highlighting the importance of methods that meet diverse needs; (3) Expectations and Entanglements: describing challenging incongruencies between implementors, practitioners and agencies; (4) Working Methodically: the significance of rigorous CW practices; and (5) Lost in Translation: implementation challenges language, culture and profession. Tailoring practices to resource‐limited communities is commendable but requires strengthening inter‐ and intra‐agency collaboration. Adopting novel practices in MCW settings requires professional implementors.
Modification of McGill Oximetry Score in Improving the Diagnostic Capability of Paediatric OSA
Authors: Wong Wannitta E. Ting , Saniasiaya Jeyasakthy , Salehuddin Nur Syazwani Mohd , H'ng Shih Ying , Nathan Anna Marie
Published: August 2024

Objectives

This study aimed to devise a modified oximetry scoring system and calculate its diagnostic accuracy in detecting paediatric obstructive sleep apnoea syndrome (OSAS).

Study Design

This prospective diagnostic accuracy study was divided into two phases.

Setting

The study was conducted at a quaternary teaching hospital.

Methods

Polysomnograms performed from 1 April 2014 to 31 December 2021 were included. In Phase 1, the parameters of 95 oximetry trend graphs were evaluated, and a modified scoring system was constructed. In Phase 2, the modified scoring system was employed in 272 oximetry trend graphs, and its diagnostic accuracy was determined. A logistic regression model was used to assess the ability of each scoring system to predict paediatric OSAS.

Results

A total of 367 patients were recruited. In Phase 1, a four‐tier severity classification system was constructed. In Phase 2, its diagnostic accuracy was found to be 53.3% sensitive, 97% specific, with positive predictive value of 98.5% and negative predictive value of 34.6%. The lowest detectable apnoea–hypopnoea index (AHI) was 4.5. The inter‐rater reliability calculated was 80%. Logistic regression was applied to assess associations of the modified McGill score (MMS) or McGill oximetry score (MOS) with OSAS. The area under the receiver operating characteristic curve was higher for the MMS than for MOS (0.78 [95% CI 0.73–0.84] vs. 0.59 [95% CI 0.51–0.66]).

Conclusion

This study demonstrated that our modified scoring system had increased sensitivity at detecting OSAS at a much lower AHI and showed a much greater ability to predict paediatric OSAS.
Transcendent emotions: A comparative study of Martin Luther's pietas and Zhu Xi's Cheng‐Jing
Authors: Jun Zhang
Published: August 2024

Both Martin Luther's pietas and Zhu Xi's Cheng‐Jing are not purely empirical emotional categories, but transcendent emotional categories of faith. By comparing Luther's pietas and Zhu Xi's Cheng‐Jing, this article reveals how Christianity and Confucianism constructed individual emotional and spiritual transcendence in early modernity. By doing so, it highlights both similarities and fundamental differences between Neo‐Confucianism and Protestantism in matters of faith, thus revealing their significance for modern society.
Royal Geographical Society (with IBG) Medals and Awards celebration 2024
Authors: Clifford Nigel , Lawrence Vanessa , Venables Stephen , Kong Lily , Clark Chris , McCarron Leon , Doerr Stefan
Published: August 2024

The Royal Geographical Society (with IBG) annual Medals and Awards recognise achievements in researching, communicating and teaching a wide range of geographical knowledge. The speeches and citations are a record of the 2024 celebrations, which occurred at the Society on 3 June 2024, with contributions from Vanessa Lawrence, Stephen Venables, Lily Kong, Chris Clark and Stefan Doerr.
Functionally graded Al2O3‐based ceramic systems by gel casting method
Authors: Topateş Gülsüm , Akça Erdem , Tür Yahya Kemal , Duran Cihangir
Published: August 2024

Functionally graded ceramic systems consisted of Al2O3/(Al2O3–ZrO2) and Al2O3/(Al2O3–Nd2Ti2O7) have been produced by gel casting. In Al2O3/ZrO2 systems, Al2O3 was gathered with three different Al2O3/ZrO2 mixtures with varying ZrO2 contents. For Al2O3/Nd2Ti2O7 system, Al2O3 layer was combined with 3 mol% Nd2Ti2O7‐doped Al2O3. All samples sintered at 1480 and 1540°C showed strong adhesion between layers without any crack formation. In the Al2O3/ZrO2 systems, both layers were intact; a distinct separation was observed, whereas a large reaction zone was observed for the Al2O3/Nd2Ti2O7 system as a consequence of reaction between both phases. The separation between layers for both systems was identified by SEM–EDX analyses. The hardness and wear tests of the samples showed that functional grading approach ensures combining various physical properties in a monolithic body.