bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges of Health Data Use in Multidisciplinary Chronic Disease Care: Perspective from Heart Failure Care
Authors: Iyngkaran Pupalan , Usmani Wania , Hanna Fahad , de Courten Maximilian
Published: December 2023

The healthcare sector generates approximately 30% of all the world’s data volume, mostly for record keeping, compliance and regulatory requirements, and patient care. Healthcare data often exist in silos or on different systems and platforms due to decentralised storage and data protection laws, limiting accessibility for health service research. Thus, both the lack of access to data and more importantly the inability to control data quality and explore post-trial (phase IV) data or data with translational relevance have an impact on optimising care and research of congestive heart failure (CHF). We highlight that for some diseases, such as CHF, generating non-traditional data has significant importance, but is hindered by the logistics of accessing chronic disease data from separate health silos and by various levels of data quality. Modern multidisciplinary healthcare management of cardiovascular diseases—especially when spanning across community hubs to tertiary healthcare centres—increases the complexities involved between data privacy and access to data for healthcare and health service research. We call for an increased ability to leverage health data across systems, devices, and countries.
Population Characteristics of the Mud Shrimp Upogebia major (De Haan, 1841) (Decapoda: Gebiidea: Upogebiidae) on Korean Tidal Flats in the Eastern Yellow Sea
Authors: Kim Sungtae , Yu Cheol , Lee Chae-Lin , Nam Sukhyun , Hong Jae-Sang
Published: December 2023

The population parameters of the ecologically important mud shrimp Upogebia major (De Haan, 1841) were analyzed from 2012 to 2015 in tidal flats in Seonjaedo and Jugyo on the west coast of Korea. The shrimp density averaged 265/m2 in Seonjaedo and 118/m2 in Jugyo. The sex ratio varied monthly, often male-biased, and, by size, males were significantly dominant, with a carapace length (CL) over 30 mm. Although the shrimp settled almost annually, only a single size-group was observed from 2012 to 2014. The recruitment in Jugyo in 2014 was notably successful, resulting in two cohorts persisting until 2015. Many shrimp were parasitized at varying local rates: 6.0% in Seonjaedo and 37.1% in Jugyo. The growth curves revealed that the shrimp grew annually after settlement, reaching CLs of 11.90, 18.24, and 23.02 mm in Seonjaedo and 13.73, 20.86, and 25.82 mm in Jugyo. Annual mortality was 77.2% in Seonjaedo and 67.4% in Jugyo. The estimated lifespan (tmax) was 10 years in Seonjaedo and 8 years in Jugyo, whereas the 2010 cohort in Jugyo largely disappeared in 5 years. Ovigerous females appeared from November to June and benthic juveniles between June and September. The shrimps’ growth was slower relative to other East Asian populations, likely due to colder sea water temperatures and altered food conditions from a higher shrimp density.
Consumer Intentions to Switch On-Demand Food Delivery Platforms: A Perspective from Push-Pull-Mooring Theory
Authors: Chang I-Chiu , Shiau Win-Ming , Lin Chih-Yu , Shih Dong-Her
Published: December 2023

With a burgeoning market and a multitude of on-demand food delivery (OFD) platforms offering diverse options, comprehending the reasons that drive consumers to switch between platforms is paramount. The push-pull-mooring (PPM) theory provides a comprehensive framework for assessing why and how consumers navigate, guiding strategic decisions for service providers seeking to optimize their offerings and retain their customer base. This research employs the PPM theory to rigorously analyze how these elements influence consumers’ intentions to switch between OFD platforms in Taiwan. Findings from a comprehensive survey of 441 OFD users reveal that both pull and mooring factors exert a significant influence on consumers’ inclination to switch platforms, collectively explaining about 42% of the switching intention. Recognizing these critical factors empowers managers to make judicious decisions aimed at enhancing platform offerings and refining marketing strategies, ultimately fortifying customer retention and bolstering satisfaction levels.
Modeling Extended Service Quality for Public Transportation in the Post-Pandemic Period: Differentiating between Urban and Rural Areas: A Case Study of Intercity Railway, Thailand
Authors: Wisutwattanasak Panuwat , Champahom Thanapong , Jomnonkwao Sajjakaj , Seefong Manlika , Theerathitichaipa Kestsirin , Kasemsri Rattanaporn , Ratanavaraha Vatanavongs
Published: December 2023

Background: Scholars have indicated differences in the attitudes of urban and non-urban populations, especially after the COVID-19 outbreak, which extend to their needs and expectations regarding rail transport development. The aim of this study is to enhance the quality of train services in the post-pandemic era, and multigroup analysis will be applied to achieve the difference in area context. Methods: The research data were collected from rail transport users throughout Thailand, consisting of 665 urban and 935 rural users. The questionnaires primarily focused on user expectations regarding rail service quality and travel conditions in the post-pandemic landscape using multigroup confirmatory factor analysis (MCFA). Results: The results unveiled significant variations in user trends and needs across different contexts and areas. In urban settings, there was a notably higher overall service expectation compared to rural areas. Specifically, urban users prioritized factors such as accessibility and service empathy, whereas rural rail users placed greater emphasis on staff quality and reasonable pricing. Conclusions: These findings furnish rail transport service agencies with valuable insights and guidance for comprehending their users’ needs. They can develop appropriate organizational strategies, service quality enhancements, and policy adjustments tailored to the unique demands of urban and rural areas in the post-pandemic era, thereby ensuring sustainability. Additionally, the methodology of multigroup analysis served as a significant scientific contribution; this showed that the statistical analysis of different area contexts in the study should not be ignored.
Molecular Dynamics Simulation of the Cu3Sn/Cu Interfacial Diffusion Mechanism under Electrothermal Coupling
Authors: He Zhiwei , Lan Xin , Li Lezhou , Cheng Yong
Published: December 2023

With the increasing power density of electronic devices, solder joints are prone to electromigration under high currents, which results in a significant threat to reliability. In this study, the molecular dynamics method is used to study the diffusion mechanism of the Cu3Sn/Cu interface under the action of electrothermal coupling. The results show that the diffusion activation energy decreases with an increase in electric field intensity, accelerating the diffusion of the Cu3Sn/Cu interface. Furthermore, it is noted that the abrupt change in the vacancy–time curve lags behind that of the mean square displacement curve, which depicts that the responses of the vacancies are driven by the electric field. The vacancy-responsive diffusion mechanism of the Cu3Sn/Cu interface is proposed. The atoms around the interface in the electric field get rid of the shackles of the neighboring atoms easily. The vacancy concentration increases as the atoms leave the equilibrium position, which accelerates the movement of vacancies and enhances the diffusion of the Cu3Sn/Cu interface.
Photocatalyst Based on Nanostructured TiO2 with Improved Photocatalytic and Antibacterial Properties
Authors: Irodia Roberta , Ungureanu Camelia , Sătulu Veronica , Mîndroiu Vasilica Mihaela
Published: December 2023

This study shows an easy way to use electrochemistry and plasma layering to make Cobalt-Blue-TiO2 nanotubes that are better at catalysing reactions. Once a titanium plate has been anodized, certain steps are taken to make oxygen vacancies appear inside the TiO2 nanostructures. To find out how the Co deposition method changed the final catalyst’s properties, it was put through electrochemical tests (to find the charge transfer resistance and flat band potential) and optical tests (to find the band gap and Urbach energy). The catalysts were also described in terms of their shape, ability to stick to surfaces, and ability to inhibit bacteria. When Cobalt was electrochemically deposited to Blue-TiO2 nanotubes, a film with star-shaped structures was made that was hydrophilic and antibacterial. The band gap energy went down from 3.04 eV to 2.88 eV and the Urbach energy went up from 1.171 eV to 3.836 eV using this electrochemical deposition method. Also, photodegradation tests with artificial doxycycline (DOX) water were carried out to see how useful the study results would be in real life. These extra experiments were meant to show how the research results could be used in real life and what benefits they might have. For the bacterial tests, both gram-positive and gram-negative bacteria were used, and BT/Co-E showed the best response. Additionally, photodegradation and photoelectrodegradation experiments using artificial doxycycline (DOX) water were conducted to determine the practical relevance of the research findings. The synergistic combination of light and applied potential leads to 70% DOX degradation after 60 min of BT/Co-E irradiation.
A Review of the Metal Additive Manufacturing Processes
Authors: Tebianian Mohaddeseh , Aghaie Sara , Razavi Jafari Nazanin , Elmi Hosseini Seyed , Pereira António , Fernandes Fábio , Farbakhti Mojtaba , Chen Chao , Huo Yuanming
Published: December 2023

Metal additive manufacturing (AM) is a layer-by-layer process that makes the direct manufacturing of various industrial parts possible. This method facilitates the design and fabrication of complex industrial, advanced, and fine parts that are used in different industry sectors, such as aerospace, medicine, turbines, and jewelry, where the utilization of other fabrication techniques is difficult or impossible. This method is advantageous in terms of dimensional accuracy and fabrication speed. However, the parts fabricated by this method may suffer from faults such as anisotropy, micro-porosity, and defective joints. Metals like titanium, aluminum, stainless steels, superalloys, etc., have been used—in the form of powder or wire—as feed materials in the additive manufacturing of various parts. The main criterion that distinguishes different additive manufacturing processes from each other is the deposition method. With regard to this criterion, AM processes can be divided into four classes: local melting, sintering, sheet forming, and electrochemical methods. Parameters affecting the properties of the additive-manufactured part and the defects associated with an AM process determine the method by which a certain part should be manufactured. This study is a survey of different additive manufacturing processes, their mechanisms, capabilities, shortcomings, and the general properties of the parts manufactured by them.
Numerical Study on the Impact of Locked-In Stress on Rock Failure Processes and Energy Evolutions
Authors: Wang Tao , Liu Zishuo , Liu Liyuan , Feng Xianhui
Published: December 2023

Locked-in stress refers to internal stress present within rock formations that can influence the failure process of rocks under specific conditions. A simplified mechanical model is applied, drawing on elasticity and the hypothesis of locked-in stress, to explore the influence of locked-in stress on the mechanical properties of loaded rocks. An analytical solution is obtained for the stress distribution in a failure model of rocks that include locked-in stress. The findings demonstrate that the geometry and orientation of stress inclusions within the rock influence the initiation and propagation of cracks under the combined influence of locked-in stress and high-stress conditions. Moreover, the presence of locked-in stress substantially reduces the rock’s capacity to withstand maximum stress, thereby increasing its susceptibility to reaching a state of failure. The increase in closure stress leads to a significant increase in the magnitude of the maximum stress drop and radial strain variation within the rock, resulting in reduced strength and a shortened life of the ageing failure of the rock. In addition, the influence of stress inclusions on energy dissipation is investigated, and a novel relationship is established between the roughness coefficient of the rock structure surface and the angle of the rock failure surface. This relationship serves to characterize the linear dynamic strength properties of rock materials containing locked-in stress. This investigation not only advances the comprehension of stress distribution patterns and the effects of locked-in stress on rock failure patterns but also facilitates a more precise portrayal of the nonlinear features of alterations in the rock stress-strain curve under the influence of confined stress. These findings provide a solid theoretical foundation for ensuring the safety of excavations in various deep engineering projects.
Analysis of Mechanical Properties of Welded Joint Metal from TPP Steam Piping after Its Operational Degradation and Hydrogenation
Authors: Hutsaylyuk Volodymyr , Student Oleksandra , Maruschak Pavlo , Krechkovska Halyna , Zvirko Olha , Svirska Lesya , Tsybailo Ivan
Published: December 2023

In this paper, the mechanical properties of various zones of the welded joints of a heat-resistant steel 15Kh1M1F in different states (in the initial state, after an operation on the main steam piping of a thermal power plant (TPP) for 23 years) were determined, and the fracture surfaces were analyzed using scanning electron microscopy (SEM) images. The effect of hydrogen electrolytic charging on mechanical behavior and fracture mechanism was also studied. The long-term operation of welds resulted in a higher degradation degree of the weld metal compared to the base one, indicated by the deterioration of mechanical properties: decrease in hardness, strength characteristics, and reduction in area, which was accompanied by an atypical increase in elongation at fracture. All studied zones of the operated welded joints were characterized by higher hydrogen content, 2.5–3 times higher than that in the initial state. Additional hydrogen charging of the weld joint metal led to a decrease in the strength and ductility characteristics, more significantly for the operated weld compared with the non-operated one. This justified the possibility of using short-term tests of hydrogenated WM in the air to assess the degree of its damage during operation on a steam piping.
Solving Fuzzy Optimization Problems Using Shapley Values and Evolutionary Algorithms
Authors: Wu Hsien-Chung
Published: December 2023

The fusion of evolutionary algorithms and the solution concepts of cooperative game theory is proposed in this paper to solve the fuzzy optimization problems. The original fuzzy optimization problem is transformed into a scalar optimization problem by assigning some suitable coefficients. The assignment of those coefficients is frequently determined by the decision-makers via their subjectivity, which may cause some biases. In order to avoid these subjective biases, a cooperative game is formulated by considering the α-level functions of the fuzzy objective function. Using the Shapley values of this formulated cooperative game, the suitable coefficients can be reasonably set up. Under these settings, the transformed scalar optimization problem is solved to obtain the nondominated solution, which will depend on the coefficients. In other words, we shall obtain a bunch of nondominated solutions depending on the coefficients. Finally, the evolutionary algorithms are invoked to find the best nondominated solution by evolving the coefficients.
Two-Stage Data Envelopment Analysis Models with Negative System Outputs for the Efficiency Evaluation of Government Financial Policies
Authors: Lychev Andrey V. , Ratner Svetlana V. , Krivonozhko Vladimir E.
Published: December 2023

The main purpose of this study is to provide a comparative analysis of several possible approaches to applying data envelopment analysis (DEA) in the case where some decision making units (DMUs) in the original sample have negative system outputs. In comparison to the traditional model of Charnes, Cooper, and Rhodes (CCR) and the CCR model with a scale shift to measure second-stage outputs, the range directional measure (RDM) model produces the most appropriate results. In this paper, an approach is proposed for estimating returns to scale. The study applies a two-stage DEA model with negative second-stage outputs to assess the public support for research, development, and demonstration projects in the energy sector in 23 countries over the period from 2010 to 2018. The assessment of government performance depends on its contribution to the growth of energy efficiency in the national economy and the reduction of its carbon intensity. Intermediate outputs (patents in the energy sector) are included in the analysis as both outputs of the first stage and inputs of the second stage. Taking the similarity between the calculations obtained without stage separation and the system efficiency calculations from the two-stage model as a measure of model adequacy, the RDM model shows the highest similarity scores.
Application of Fixed Point Result in Complex Valued Extended b-Metric Space
Authors: Shammaky Amnah Essa , Ahmad Jamshaid
Published: December 2023

The aim of the present research work is to investigate the solution of Urysohn integral equation by common fixed point result in the setting of complex valued b-metric space. To obtain the objective, we used a generalized rational contraction involving control functions and a pair of self-mappings. In this way, we generalize some well-known results of literature. Some non-trivial examples are also flourished to demonstrate the innovation of our principal result.
Predictive Factors for Pregnancy-Related Persistent Pelvic Girdle Pain (PPGP): A Systematic Review
Authors: Burani Elisa , Marruganti Sharon , Giglioni Gloria , Bonetti Francesca , Ceron Daniele , Cozzi Lepri Alessandro
Published: December 2023

Background and Objectives: To identify the most frequently reported predictive factors for the persistency of pregnancy-related pelvic girdle pain (PPGP) at 3–6 months after childbirth in women with PPGP alone or PPGP in association with pregnancy-related lower back pain (PLBP). Methods: Eligibility criteria: Two authors independently selected studies excluding PPGP determined by a specific, traumatic, gynecological/urological cause or isolated PLBP and studies that did not include the presence/absence of PPGP as the the primary outcome. We, instead, included studies with an initial assessment in pregnancy (within 1 month of delivery) and with a follow-up of at least 3 months after delivery. Data sources: The research was performed using the databases of Medline, Cochrane, Pedro, Scopus, Web of Science and Cinahl from December 2018 to January 2022, following the indications of the PRISMA statement 2021 and the MOOSE checklist. It includes observational cohort studies in which data were often collected through prospective questionnaires (all in English). Study appraisal and risk of bias: Two independent authors performed evaluations of the risk of bias (ROB) using the quality in prognostic studies (QUIPS) tool. Synthesis of results: An in-depth qualitative analysis was conducted because, due to a high degree of heterogeneity in the data collection of the included studies and a lack of raw data suitable for quantitative analysis, it was not possible to carry out the originally planned meta-analyses for the subgroups. Results: The research process led to the inclusion of 10 articles which were evaluated using the QUIPS tool: 5 studies were evaluated as low ROB and 5 were evaluated as moderate ROB. High levels of pain in pregnancy, a large number of positive provocation tests, a history of lower back pain and lumbo-pelvic pain, high levels of disability in pregnancy, neurotic behavior and high levels of fear-avoidance belief were identified as strong predictors of long-term PPGP, while there was weak or contradictory evidence regarding predictions of emotional distress, catastrophizing and sleep disturbances. Discussion: The impossibility of carrying out the meta-analysis by subgroups suggests the need for further research with greater methodological rigor in the acquisition of measures based on an already existing PPGP core predictors/outcome sets.
An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture
Authors: Doesburg-van Kleffens Marjolein , Zimmermann-Klemd Amy M. , Gründemann Carsten
Published: December 2023

Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—such as pellotine, anhalonidine, hordenine and mescaline. Here, mescaline induces the psychoactive effects of peyote through the activation of the serotonin 5-HT2A receptor and the subsequent release of calcium (Ca2+) from the endoplasmic reticulum (ER). Moreover, an evaluation of the therapeutic benefits of mescaline is also currently the subject of research. It is important to consider that the outcome of taking a psychedelic drug strongly depends on the mindset of the recipient and the context (set and setting principle), including ceremonies and culture. This overview serves to summarise the current state of the knowledge of the metabolism, mechanism of action and clinical application studies of peyote and mescaline. Furthermore, the benefits of the potential of peyote and mescaline are presented in a new light, setting an example for combining a form of treatment embedded in nature and ritually enriched with our current highly innovative Western medicine.
Biotransformation of Ursonic Acid by Aspergillus ochraceus and Aspergillus oryzae to Discover Anti-Neuroinflammatory Derivatives
Authors: Wu Yan-Ni , Su Dan , Yang Jia , Yi Ying , Wang An-Dong , Yang Min , Li Jian-Lin , Fan Bo-Yi , Chen Guang-Tong , Wang Wen-Li , Ling Bai
Published: December 2023

Biotransformation of ursonic acid (1) by two fungal strains Aspergillus ochraceus CGMCC 3.5324 and Aspergillus oryzae CGMCC 3.407 yielded thirteen new compounds (4, 5, 7–10, and 13–19), along with five recognized ones. The structural details of new compounds were determined through spectroscopic examination (NMR, IR, and HR-MS) and X-ray crystallography. Various modifications, including hydroxylation, epoxidation, lactonization, oxygen introduction, and transmethylation, were identified on the ursane core. Additionally, the anti-neuroinflammatory efficacy of these derivatives was assessed on BV-2 cells affected by lipopolysaccharides. It was observed that certain methoxylated and epoxylated derivatives (10, 16, and 19) showcased enhanced suppressive capabilities, boasting IC50 values of 8.2, 6.9, and 5.3 μM. Such ursonic acid derivatives might emerge as potential primary molecules in addressing neurodegenerative diseases.
Two-Dimensional Transition Metal Boride TMB12 (TM = V, Cr, Mn, and Fe) Monolayers: Robust Antiferromagnetic Semiconductors with Large Magnetic Anisotropy
Authors: Zhang Huiqin , Guo Nini , Wang Ziyu , Xiao Yuqi , Zhu Xiangfei , Wang Shu , Yao Xiaojing , Liu Yongjun , Zhang Xiuyun
Published: December 2023

Currently, two-dimensional (2D) materials with intrinsic antiferromagnetism have stimulated research interest due to their insensitivity to external magnetic fields and absence of stray fields. Here, we predict a family of stable transition metal (TM) borides, TMB12 (TM = V, Cr, Mn, Fe) monolayers, by combining TM atoms and B12 icosahedra based on first-principles calculations. Our results show that the four TMB12 monolayers have stable antiferromagnetic (AFM) ground states with large magnetic anisotropic energy. Among them, three TMB12 (TM=V, Cr, Mn) monolayers display an in-plane easy magnetization axis, while the FeB12 monolayer has an out-of-plane easy magnetization axis. Among them, the CrB12 and the FeB12 monolayers are AFM semiconductors with band gaps of 0.13 eV and 0.35 eV, respectively. In particular, the AFM FeB12 monolayer is a spin-polarized AFM material with a Néel temperature of 125 K. Moreover, the electronic and magnetic properties of the CrB12 and the FeB12 monolayers can be modulated by imposing external biaxial strains. Our findings show that the TMB12 monolayers are candidates for designing 2D AFM materials, with potential applications in electronic devices.
Mechanochemical-Assisted Extraction and Biological Activity Research of Phenolic Compounds from Lotus Seedpod (Receptaculum Nelumbinis)
Authors: Bao Nina , Song Jiajia , Zhao Xinyuan , Rashed Marwan M. A. , Zhai Kefeng , Dong Zeng
Published: December 2023

To explore the feasibility of the mechanochemical-assisted extraction (MCAE) of phenolic compounds from lotus seedpod (Receptaculum Nelumbinis), a single-factor experiment combined with response-surface methodology (RSM) was used to optimize the extraction process. The results showed the optimal extraction conditions as follows: Li2CO3 as a solid reagent (25%), an extraction time of 80 min, liquid/solid ratio of 42.8 mL/g, and extraction temperature of 80.7 °C; and the maximum value of total phenolic content (TPC) was 106.15 ± 1.44 gallic acid equivalents (GAE)/g dry weight (DW). Additionally, the 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) were 279.75 ± 18.71, 618.60 ± 2.70, and 634.14 ± 7.17 µmol TE/g, respectively. Ultra-high pressure liquid chromatography combined with triple-time-of-flight mass spectrophotometry (UPLC-Triple-TOF/MS) analysis identified eight phenolic compounds mainly consisting of polyphenols and flavonoids. Moreover, the phenolic compounds showed potent inhibitory effects on both α-amylase and α-glucosidase, with inhibition rates of over 80%. Furthermore, the results showed different degrees of inhibition activity against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli, among which the inhibitory effect on the growth of B. subtilis was the best. This paper shows that the phenolic compounds have good biological activities, which provides a reference for the further exploitation of LSP.
The Inhibition of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ-Exposed THP-1 Cells
Authors: Maugeri Alessandro , Russo Caterina , Patanè Giuseppe Tancredi , Barreca Davide , Mandalari Giuseppina , Navarra Michele
Published: December 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by an increased level of β-amyloid (Aβ) protein deposition in the brain, yet the exact etiology remains elusive. Nowadays, treatments only target symptoms, thus the search for novel strategies is constantly stimulated, and looking to natural substances from the plant kingdom. The aim of this study was to investigate the neuroprotective effects of a spice blend composed of cinnamon bark and two different turmeric root extracts (CCSB) in Aβ-exposed THP-1 cells as a model of neuroinflammation. In abiotic assays, CCSB demonstrated an antioxidant capacity up to three times stronger than Trolox in the ORAC assay, and it reduced reactive oxygen species (ROS) induced by the amyloid fragment in THP-1 cells by up to 39.7%. Moreover, CCSB lowered the Aβ stimulated secretion of the pro-inflammatory cytokines IL-1β and IL-6 by up to 24.9% and 43.4%, respectively, along with their gene expression by up to 25.2% and 43.1%, respectively. The mechanism involved the mitogen-activated protein kinases ERK, JNK and p38, whose phosphorylation was reduced by up to 51.5%, 73.7%, and 58.2%, respectively. In addition, phosphorylation of p65, one of the five components forming NF-κB, was reduced by up to 86.1%. Our results suggest that CCSB can counteract the neuroinflammatory stimulus induced by Aβ-exposure in THP-1 cells, and therefore can be considered a potential candidate for AD management.
Chlorine in an Organic Molecule, a Universal Promoter—Workhorse—Of Reactions
Authors: Mąkosza Mieczysław , Fedoryński Michał
Published: December 2023

Due to the electronic configuration of the atom and charge of the nucleus, the chlorine in organic molecules can exert a variety of effects. It can depart as a chloride anion in the process of substitution and elimination, facilitates the abstraction of protons and stabilizes generated carbanions, exerts moderate stabilizing effect of carbenes, carbocations and radicals. There are frequent cases where chlorine substituent promotes more than one transformation. These rich effects of chlorine substituent will be illustrated by examples of our work.
Rapid Authentication and Detection of Olive Oil Adulteration Using Laser-Induced Breakdown Spectroscopy
Authors: Nanou Eleni , Pliatsika Nefeli , Couris Stelios
Published: December 2023

The adulteration of olive oil is a crucial matter for food safety authorities, global organizations, and consumers. To guarantee olive oil authenticity, the European Union (EU) has promoted the labeling of olive oils with the indices of Protected Designation of Origin (PDO) and Protected Geographical Identification (PGI), while food security agencies are also interested in newly emerging technologies capable of operating reliably, fast, and in real-time, either in situ or remotely, for quality control. Among the proposed methods, photonic technologies appear to be suitable and promising for dealing with this issue. In this regard, a laser-based technique, namely, Laser-Induced Breakdown Spectroscopy (LIBS), assisted via machine learning tools, is proposed for the real-time detection of olive oil adulteration with lower-quality oils (i.e., pomace, soybean, sunflower, and corn oils). The results of the present work demonstrate the high efficiency and potential of the LIBS technique for the rapid detection of olive oil adulteration and the detection of adulterants.
Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice
Authors: Denker Hans-Werner
Published: December 2023

While research on stem cell-derived tissues and organoids is rapidly expanding, the technically related creation of complex embryoids has recently excited a vivid discussion since it raises ethical questions about individuation and the possible gain of viability. The present study focuses on the onset of organismic development and the proposed biological and legal definitions for the terms embryo, embryoid, and organoid. It is concluded that such considerations have become important for investigators’ choices of the appropriate in vitro model systems, allowing the formation of organoids vs. complex embryoids.
Toxoplasma gondii in Marine Life of Italian Coasts, What Do We Know So Far?
Authors: Rodriguez-Fernandez Veronica , Bruschi Fabrizio
Published: December 2023

Coastal areas of Italy experience high anthropogenic pressure, with a population density estimated to be 360 people per km2. This is correlated with the production of sewage or surface runoff of water contaminated with Toxoplasma gondii oocysts and other pathogens that can in turn enter the food chain and become a public health concern. Therefore, in the present study, we want to review the current knowledge on the presence of T. gondii in Italian coastal areas. The majority of research in Italy has been carried out on marine mammals, while fishes and mollusks have less often been screened. So far, T. gondii has been found in all sea animals tested, with genotypes II and III as well as atypical genotypes being the most commonly found when screened. However, more information is needed. We encourage routine screening of mollusks and fish that are sold in different food markets throughout the country in order to add information on the distribution of T. gondii and other parasites, preventing possible future outbreaks.
Drug Safety and Relevant Issues in the Real-World
Authors: Barbieri Maria Antonietta , Irrera Natasha , Convertino Irma
Published: December 2023

The global impact of the COVID-19 pandemic has underscored the pivotal role of drug safety and effective communication within the realm of pharmacovigilance, particularly in times of unprecedented public health emergencies [...]
Special Issue: Evaluation of the Antitumor Mechanism of Armed Antibodies
Authors: Koga Yoshikatsu , Takashima Hiroki , Koganemaru Shigehiro
Published: December 2023

This Special Issue focuses on the use of therapeutic antibodies in vitro, in vivo, and in clinical studies [...]
Analog Wavelength Locking in an Optical Single-Sideband Transmitter of a Millimeter-Wave Radio-Over-Fiber Link Featuring a Micro-Ring Resonator and a Heat-Pump-Controlled Laser
Authors: Vuk Baliž Kristjan , Debevc Andraž , Vidmar Matjaž , Batagelj Boštjan
Published: December 2023

This paper presents a novel approach to addressing the issue of temperature-induced instability in an optical, single-sideband transmitter based on a micro-ring resonator (MRR) suitable for millimeter-wave (mmW) radio-over-fiber (RoF) communications. We propose utilizing the drop port of the MRR to provide a feedback signal to the closed-loop control (CLC) system. The latter serves to maintain the optimal alignment between the laser’s carrier and the MRR’s resonant wavelength, thus mitigating the adverse effects of chromatic-dispersion-induced power fading at the receiving end. Since the feedback information is extracted from the otherwise-wasted resonant energy at the drop port, the control system does not compromise the delicate optical signal at the through port. A CLC was synthesized, designed, and prototyped to provide real-time wavelength tuning of the heat-pump-controlled laser based on the feedback signal. Experimental evaluations demonstrate that the wavelength of the laser could be successfully locked to the MRR’s resonance with a wavelength dither of less than 0.004 nm (~491 MHz). This allowed us to limit the power-penalty deterioration to less than 2 dB for a RoF link with a 2.5-km standard telecommunication single-mode fiber (SMF), a modulation frequency of 37.8 GHz, and a carrier wavelength of 1563.97 nm (~191.820 THz). The proposed solution offers an alternative approach for the carrier and the MRR’s resonant wavelength interlocking without the need for complex photonics like thermo-optic or electro-optic structures to control the temperature or phase velocity, respectively.
All-Fiber Pulse-Train Optical Frequency-Domain Interferometer for Dynamic Absolute Distance Measurements of Vibration
Authors: Ma Heli , Liu Cangli , Chen Long , Tang Longhuang , Tao Tianjiong , Wu Jian , Liu Shenggang , Jia Xing , Li Chengjun , Wang Xiang , Weng Jidong
Published: December 2023

In this paper, we propose an all-fiber co-axial optical frequency-domain interferometer (OFDI) in a pulse-train mode with a sample rate of 9 kHz for measuring the vibrations in an internal structure without any contact. It was subjected to a range of 4.555 mm and had an accuracy level of 0.006 mm, as confirmed by a linear motion experiment. Due to the precise time synchronization for reducing the background light leakage and suppressing the dynamic fuzziness, the proposed OFDI could realize the dynamic absolute distance measurements of the vibration process under harmonic excitation with frequencies ranging from 200 Hz to 1800 Hz. The characteristic parameters of vibration could be analyzed using the acquired distance results. Furthermore, the OFDI system obtained the frequency conversion as the time under anharmonic periodic excitation with a sweeping rate of 3600 Hz/s. The measurement performance for the vibration velocity compared with the displacement interferometer system for any reflector (DISAR) was demonstrated in a harmonic excitation experiment. The proposed method expands the application of all-fiber OFDI technology from static to dynamic scenes.
Hybridization Effect on Interlaminar Bond Strength, Flexural Properties, and Hardness of Carbon–Flax Fiber Thermoplastic Bio-Composites
Authors: Bahrami Mohsen , del Real Juan Carlos , Mehdikhani Mahoor , Butenegro José Antonio , Abenojar Juana , Martínez Miguel Ángel
Published: December 2023

Hybridizing carbon-fiber-reinforced polymers with natural fibers could be a solution to prevent delamination and improve the out-of-plane properties of laminated composites. Delamination is one of the initial damage modes in composite laminates, attributed to relatively poor interlaminar mechanical properties, e.g., low interlaminar strength and fracture toughness. This study examined the interlaminar bond strength, flexural properties, and hardness of carbon/flax/polyamide hybrid bio-composites using peel adhesion, three-point bending, and macro-hardness tests, respectively. In this regard, interlayer hybrid laminates were produced with a sandwich fiber hybrid mode, using woven carbon fiber plies (C) as the outer layers and woven flax fiber plies (F) as the inner ones (CFFC) in combination with a bio-based thermoplastic polyamide 11 matrix. In addition, non-hybrid carbon and flax fiber composites with the same matrix were produced as reference laminates to investigate the hybridization effects. The results revealed the advantages of hybridization in terms of flexural properties, including a 212% higher modulus and a 265% higher strength compared to pure flax composites and a 34% higher failure strain compared to pure carbon composites. Additionally, the hybrid composites exhibited a positive hybridization effect in terms of peeling strength, demonstrating a 27% improvement compared to the pure carbon composites. These results provide valuable insights into the mechanical performance of woven carbon–flax hybrid bio-composites, suggesting potential applications in the automotive and construction industries.
The Effect of Hollow Glass Microspheres on the Kinetics of Oxidation of Poly(ε-Caprolactone) Determined from Non-Isothermal Thermogravimetry and Chemiluminescence
Authors: Vykydalová Anna , Špitálský Zdenko , Kováčová Mária , Rychlý Jozef
Published: December 2023

The effect of hollow glass beads on poly(ε-caprolactone) (PCL) oxidative degradation has been evaluated by the non-isothermal chemiluminescence (CL) method and thermogravimetry analysis (TGA). The main goal of the research and this publication was to reduce the production costs associated with the materials for 3D printing, which would also have a low mass, excellent biocompatibility and suitable thermal properties. Experiments have clearly shown the dual effect of a filler and its extent in terms of poly(ε-caprolactone). The chosen methods demonstrate the superposition of both the pro-degradation and stabilization effects of hollow glass beads on the polymer. The former was evident above the load of 10 wt.% of filler. The non-isothermal TGA records were analyzed as being composed of three temperature-dependent processes of the first-order kinetics. A massive compensation effect between the so-called activation energy and the logarithm of pre-exponential factors for heating rates of 2.5, 5 and 10 °C/min has been shown to be typical for similar non-isothermal thermogravimetry evaluation.
Design and Optimization of Precision Fertilization Control System Based on Hybrid Optimized Fractional-Order PID Algorithm
Authors: Wang Hao , Zhang Lixin , Hu Xue , Wang Huan
Published: December 2023

In order to mitigate time-varying, lag, and nonlinearity impacts on fertilization systems and achieve precise control of liquid conductivity, we propose a novel hybrid-optimized fractional-order proportional-integral-derivative (PID) algorithm. This algorithm utilizes a fuzzy algorithm to tune the five parameters of the fractional-order PID algorithm, employs the Smith predictor for structural optimization, and utilizes Wild Horse Optimizer, improved by genetic algorithms, to optimize fuzzy rules. We conducted MATLAB simulations, precision experiments, and stability tests on this controller. MATLAB simulation results, along with precision experiment results, indicate that compared to PID controllers, Smith predictor-optimized PID controllers, and fuzzy-tuned fractional-order PID controllers, the proposed controller has the narrowest steady-state conductivity range, the shortest settling time, and the lowest overshoot, showcasing excellent overall dynamic performance. Stability test results demonstrate that the controller maintains stable operation under different pressure conditions. Therefore, this control system from our study achieves superior control effectiveness, providing a viable approach for the control of nonlinear time-delay systems.
Learning from Experience: Liturgical Formation as a Central Component of Religious Education in Schools
Authors: Seper Daniel
Published: December 2023

Religious education in schools was, for a long time, liturgically shaped until liturgical formation was no longer seen as a task of schools but of parish catechesis in many countries. Current approaches try to develop a liturgical didactic that is adapted to the school as a place of learning. Based on the confessional model of religious education in Austria, this paper shows the challenges and significance of liturgical formation in reference to Pope Francis’ letter Desiderio Desideravi. In combining perspectives of religious education and liturgical studies, the necessary conditions for liturgical formation to succeed are shown. A didactic of Catholic liturgy that builds on established didactics and strives for liturgical formation on the cutting edge is presented, adapted to the setting of schools and distinct from parish catechesis. One way of responding to the lack of experience is with the help of performative didactics to enable practical experiences that, framed in reflection, form the basis for engagement with the liturgy. Such a liturgical didactic aims at enabling competence in matters of worship, considering all people, if a renewed understanding of liturgy is taken seriously, according to which worship is the celebration of the whole assembly and therefore requires a corresponding participation of all.
Diffractive Sail-Based Displaced Orbits for High-Latitude Environment Monitoring
Authors: Bassetto Marco , Mengali Giovanni , Quarta Alessandro A.
Published: December 2023

This paper analyzes the possibility of maintaining a circular displaced non-Keplerian orbit around the Sun by means of a Sun-facing diffractive sail. With the goal of monitoring the Earth’s high-latitude regions, the spacecraft is required to track its displaced orbit at an angular velocity equal to the mean motion of the planet. In doing so, the spacecraft keeps a constant average phase shift with respect to Earth’s angular position along its orbit, allowing the objectives of the scientific mission to be achieved. The diffractive sail, recently proposed by Swartzlander and chosen in this paper as the spacecraft’s primary propulsion system, is a special photonic solar sail in which the membrane film is covered by an advanced diffractive metamaterial. In particular, a Sun-facing diffractive sail with a grating at normal incidence generates radial and transverse thrust components of equal magnitude; that is, the thrust vector is tilted 45 degrees from the Sun-spacecraft line. This peculiarity enables the diffractive sail to maintain a family of circular displaced non-Keplerian orbits, each of which is characterized by unique values of radius and a lightness number for an assigned value of spacecraft displacement relative to the Ecliptic. A comparison with the ideal reflecting sail shows that the diffractive sail performs better because for the same overall spacecraft mass, the latter needs about 30% less surface area exposed to the Sun. Finally, this paper discusses the classical stability problem, assuming an error in orbit insertion of the diffractive sail-based spacecraft. In this context, extensive numerical simulations show that such displaced orbits are marginally stable.
Efficient 3D Frequency Semi-Airborne Electromagnetic Modeling Based on Domain Decomposition
Authors: Hui Zhejian , Wang Xuben , Yin Changchun , Liu Yunhe
Published: December 2023

Landslides are common geological hazards that often result in significant casualties and economic losses. Due to their occurrence in complex terrain areas, conventional geophysical techniques face challenges in early detection and warning of landslides. Semi-airborne electromagnetic (SAEM) technology, utilizing unmanned aerial platforms for rapid unmanned remote sensing, can overcome the influence of complex terrain and serve as an effective approach for landslide detection and monitoring. In response to the low computational efficiency of conventional semi-airborne EM 3D forward modeling, this study proposes an efficient forward modeling method. To handle arbitrarily complex topography and geologic structures, the unstructured tetrahedron mesh is adopted to discretize the earth. Based on the vector finite element formula, the Dual–Primal Finite Element Tearing and Interconnecting (FETI-DP) method is further applied to enhance modeling efficiency. It obtains a reduced order subsystem and avoids directly solving huge overall linear equations by converting the entirety problem into the interface problem. We check our algorithm by comparing it with 1D semi-analytical solutions and the conventional finite element method. The numerical experiments reveal that the FETI-DP method utilities less memory and exhibits higher computation efficiency than the conventional methods. Additionally, we compare the electromagnetic responses with the topography model and flat earth model. The comparison results indicate that the effect of topography cannot be ignored. Further, we analyze the characteristic of electromagnetic responses when the thickness of the aquifer changes in a landslide area. We demonstrate the effectiveness of the 3D SAEM method for landslide detection and monitoring.
Correcting for Mobile X-Band Weather Radar Tilt Using Solar Interference
Authors: Dufton David , Bennett Lindsay , Wallbank John R. , Neely Ryan R.
Published: December 2023

Precise knowledge of the antenna pointing direction is a key facet to ensure the accuracy of observations from scanning weather radars. The sun is an often-used reference point to aid accurate alignment of weather radar systems and is particularly useful when observed as interference during normal scanning operations. In this study, we combine two online solar interference approaches to determine the pointing accuracy of an X-band mobile weather radar system deployed for 26 months in northern England (54.517°N, 3.615°W). During the deployment, several shifts in the tilt of the radar system are diagnosed between site visits. One extended period of time (>11 months) is shown to have a changing tilt that is independent of human intervention. To verify the corrections derived from this combined approach, quantitative precipitation estimates (QPEs) from the radar system are compared to surface observations: an approach that takes advantage of the variations in the magnitude of partial beam blockage corrections required due to tilting of the radar system close to mountainous terrain. The observed improvements in QPE performance after correction support the use of the derived tilt corrections for further applications using the corrected dataset. Finally, recommendations for future deployments are made, with particular focus on higher latitudes where solar interference spikes show more seasonality than those at mid-latitudes.