bluuebunny/crossref_metadata_2025 huggingface dataset:
MATERIAL PERUBAH FASA BERBASIS Ethylene Prophylene Diene Monomer (EPDM) UNTUK PENYIMPANAN ENERGI PANAS
Authors: Izzati Isra Adelya
Published: June 2021

Bahan pengubah fasa banyak digunakan sebagai kapasitor termal dalam sistem panas matahari. Untuk pemanfaatan panas matahari, material pengubah fasa harus memiliki entalpi yang besar, konduktivitas termal, sifat mekanik yang baik, dan kinerja foto-termal. Bahan perubahan fasa dengan bahan karbon dapat langsung menyerap energi matahari dan ditransfer ke air untuk pemanas gedung. bahan pengubah fase berbasis Ethylene-Propylene-Diene Monomer (EPDM) dengan grafit yang diperluas disiapkan. Selain itu, mekanisme konversi foto-termal bahan perubahan fasa jarang dilaporkan. Di sini, tingkat pengisian energi foto-termal dan efisiensi foto-termal bahan perubahan fasa diselidiki dengan metode gabungan numerik dan eksperimental. SiO 2 aerogel pertama kali digunakan sebagai insulator termal dalam sistem panas matahari dengan transmisi tinggi dan konduktivitas termal rendah. Bahan perubahan fasa dengan SiO2 aerogel bisa menahan panas yang hilang di permukaan. Bahan perubah fasa memiliki kinerja foto-termal yang baik dalam sistem panas matahari, bisa panaskan lebih dari 200 L air panas di siang hari.Kata kunci : Bahan Perubah Fasa, EPDM, Foto Termal
Die Politisierung der Lust
Authors: Herzog Dagmar
Published: June 2021

Politik und Sexualität sind von jeher eng verknüpft. Debatten über Sexualmoral dienten im Deutschland des 20. Jahrhunderts immer auch der Aushandlung von politischen Prozessen, vor allem der Auseinandersetzung mit Schuld und Erinnerung in der Nachkriegszeit.

Dagmar Herzog arbeitet die zentrale Bedeutung von Sexualität für das Verständnis historischer Entwicklungen heraus. Sie zeichnet die Sexualgeschichte Deutschlands von der Zeit des Nationalsozialismus über die verkrustete Adenauer Ära, den Aufbruch der 1968er und die realsozialistische DDR bis hin zur Wiedervereinigung nach und zeigt, wie Sexualität, Moral und Erinnerung miteinander verwoben sind. Dabei räumt sie unter anderem mit vermeintlichen Gewissheiten über die Zeit des Nationalsozialismus auf, die keineswegs so lust- und sexualfeindlich war, wie es oft dargestellt wird.
Psychoanalyse als Dialog
Authors: Mitchell Stephen A.
Published: June 2021

Stephen A. Mitchells Werk ist eine glänzende Synthese zahlreicher Ansätze, die die Psychoanalyse unserer Zeit transformiert haben. Aufbauend auf der kleinianischen Theorie, der Interpersonalen Psychoanalyse sowie progressiven freudianischen Ansätzen beschäftigt er sich eingehend mit den verschiedenen Aspekten therapeutischen Handelns: von Anonymität und Neutralität über das Wesen analytischen Wissens bis zu Autorität. Er erläutert eine Vielzahl unterschiedlicher Arten, über die interaktive Natur der analytischen Situation nachzudenken, und regt zur weiteren Reflexion an. So wird ein umfassendes Verständnis der interaktiven Prozesse zwischen AnalysandIn und AnalytikerIn ermöglicht.
Variabilidad y estructura genética de poblaciones de Schizachyrium (Poaceae, Andropogoneae) de la provincia de Corrientes (Argentina)
Authors: Almirón Noelia E. A. , Moreno Ercilia M. S. , Peichoto Myriam C. , Solís Neffa Viviana G.
Published: June 2021

A fin de evaluar la utilidad de los estudios genético-poblacionales en la identificación de especies de Schizachyrium y en el papel de la hibridación natural en la evolución de dichas especies, se analizó la variabilidad y estructura genética de S. bimucronatum, S. sanguineum y S. tenerum. La identificación de bandas RAPDs y haplotipos de ADNcp exclusivos, sumados a los resultados del PCoA y AMOVA evidenciaron que dichas especies difieren genéticamente entre sí. La consistencia de estos resultados con la distinción de grupos morfológicos definidos previamente, sugiere que los análisis genético-poblacionales basados en marcadores nucleares y de cloroplastos combinados podrían contribuir a la identificación inequívoca de las especies de Schizachyrium. Asimismo, el hallazgo de algunos individuos con una proporción de sus genomas asignable a los de otras poblaciones o especies, sugiere la ocurrencia de eventos de hibridación seguida de introgresión o de poliploidización. Finalmente, los patrones de estructuración genética observados estarían relacionados a las características de los sistemas reproductivos de las especies estudiadas; mientras que la identificación de unidades evolutivas independientes en dichas especies sería de interés para el desarrollo de estrategias de conservación de las especies y de las comunidades que integran.
Investigation of Factors Affecting Pre-School Teachers’ Vocational Alienation
Authors:   Erciyes University (Turkey), Mutlu Neşet , Öcal Sümeyye ,   İstanbul Gelisim University (Turkey)
Published: June 2021

Preschool teachers have an important place in achieving the goals of preschool education and in assuring its quality. Since vocational alienation affect preschool teachers' performance negatively, main purpose of this study is to investigate factors affecting their vocational alienation. For this purpose 227 pre-school teachers from Turkey voluntarily participated in the study. The model of the study was correlational survey model. Research data was collected with; Personal Information Form, Vocational Alienation Scale for the Preschool Teachers (VAS-PT), Organizational Climate Scale and Preschool Teachers' Self-Efficacy Beliefs Scale. According to teachers’ graduation degree variable, the vocational alienation scale scores of teachers at the graduate level differed statistically negatively from other groups (high school, associate degree, undergraduate). The scores of the sub-dimensions of the scale of vocational alienation of the group consisting of teachers who have a different vocation they want to do, differ negatively compared to other colleagues. Between teachers' vocational alienation scores and self-efficacy beliefs and organizational climate scores, positive and negative significant relationships were determined. There were significant negative relationships between teachers' vocational alienation scores and all sub-dimensions of the Self-Efficacy Belief Scale. Negative relationships were determined among the scores of all sub-dimensions of Vocational Alienation Scale for Pre-school Teachers and "Supportive Principle Behavior," "Intimate Teacher Behavior" and “Collaborative Teacher Behavior among Colleagues” of the Organizational Climate Scale. In addition, there were positive relationships between "Disengaged Teacher Behavior" and "Restrictive Principle Behavior" dimensions of Organizational Climate Scale and all sub-dimensions of Vocational Alienation Scale for Pre-school Teachers.
THE IMPORTANCE OF REPAIRS FOR MAINTAINING THE PROPER TECHNICAL CONDITION OF FIXED ASSETS OF COKE-CHEMICAL ENTERPRISES (review)
Authors: Fidchunov A.L. , Shulga T.I.
Published: June 2021

Due to the excess operating life of the operating coke oven batteries in Ukraine, it is necessary to systematically carry out repairs to maintain the proper technical condition of the fixed assets of the coke oven production, primarily coke oven batteries. The article provides definitions of such concepts as the system of scheduled preventive maintenance of industrial buildings and structures, the system of maintenance and repair of mechanical equipment, maintenance, current repairs, major repairs, and the like. A classification of coke oven masonry repairs according to the scope of work, conditions and time of performance is stated, as well as documents regulating the procedure for their implementation are named. A brief overview of the types of repairs that are used to maintain the technical condition of coke oven batteries: preventive and current repairs (gunning, etc.), Medium repairs (partial relocation of the heads of the regenerator walls, heating walls and replacement of the reflowed packing), overhaul, which consists of partial re-laying a group of furnaces in a cold state (repairing furnace masonry with shifting walls to different depths, repairing and replacing reinforcement, repairing and replacing chimney and gas supply fittings). The main defects of coke oven battery masonry, which are subject to major repairs, are listed. It is noted that the cold group partial relocation of the furnaces is performed with gradual cooling and heating, which requires a complete or partial cessation of operation of the chambers adjacent to the ones being repaired (buffer and semi-buffer furnaces). It is emphasized that the work performed as part of the overhaul is determined by the technical condition of the battery, regardless of its age. It is noted that in modern conditions, the most effective is the relocation of the extreme and pre-extreme verticals of the coking chamber to a depth of 4-6 verticals on both sides without disconnecting the repaired chamber from heating. Keywords: coke oven battery, service life, technical condition, types of repairs, regulatory documentation. Corresponding author Fidchunov A.L., e-mail: fich.aleks@gmail.com
Police functions of magistrates in the legislation of the Russian Empire of the 18th century
Authors: Klimov Andrey , Saleeva Yuliya
Published: June 2021

Based on the analysis of normative legal acts regulating the activities of magistrates in the cities of the Russian Empire, the article identifies, summarizes and describes the police functions of magistrates performed by them along with administrative, judicial, fiscal and other functions, and also shows the role of city self-government bodies in the formation and development of police in the cities of the Russian Empire of the XVIII century.
Sepsis-associated acute kidney damage is a disease that affects the patient's quality of life. It should be a target for gene therapy
Authors: Dowaidar Moataz
Published: June 2021

Sepsis-associated acute kidney damage is a disease that affects the patient's quality of life as well as their chances of dying. While supportive care can be useful for helping patients live longer if their health improves, there are no therapies that are directed at modifying the underlying pathophysiology. More recent studies show that changes in gene expression, protein abundance, and metabolism can alter kidney function in sepsis, which further demonstrates how far we've come in the past decade when it comes to our understanding of the underlying mechanisms of sickness. While significant progress has been made, the opportunity provided by current omic technologies to illuminate these paths has yet to be realized.To help us provide better healthcare for our sickest patients, we're recommending future research go along the following lines: First, conduct in-depth research on recent advancements in both fundamental and clinical science to take advantage of new imaging technologies that have been developed in the last several years. Next, exploit recent breakthroughs in fundamental and clinical science to use new imaging technologies that have been established over the last several years.
Biological medications for interventional pain have a lot of clinical data behind them. It is fair to assume they will replace steroid-based interventional techniques, providing patients with longer relief
Authors: Dowaidar Moataz
Published: June 2021

This overview of current studies on the use and effectiveness of stem cell therapy for chronic pain should serve as a reminder of the growing body of data that supports these therapies, particularly Platelet-rich plasma (PRP) injections. Due to a scarcity of high-quality randomized controlled trials on the subject, the great majority of evidence for chronic pain treatment is graded as level II to level IV. While there are no new panaceas in pain management described in this study, the level of evidence for PRP intra-articular knee injections in terms of pain management should be particularly remarkable. This is a landmark event in the field of interventional pain, and it should serve as evidence that these biological medications have a lot of clinical data behind them.With increasing clinical data and future experimental data into more targeted gene modulation therapies, it is fair to assume that these treatments will ultimately replace present steroid-based interventional techniques, providing patients with longer relief and higher clinical benefit. Furthermore, similar to many other medical areas that have strived to stress the need for preventive medicine, pain management doctors may one day harness the regenerative potential of these medicines to better treat their patients and battle the mounting socioeconomic consequences of this illness.
The murburn precepts for cellular ionic homeostasis and electrophysiology
Authors: Manoj Kelath Murali , Bazhin Nikolai , Tamagawa Hirohisa
Published: June 2021

Starting from basic molecular structure and redox properties of its components, we build a macroscopic cellular electrophysiological model. We first present a murburn purview that could explain ion-distribution in bulk-milieu/membrane-interface and support the origin of trans-membrane potential (TMP) in cells. In particular, the discussion focuses on how cells achieve disparity in the distribution of monovalent and divalent cations within (K+ > Na+ > Mg2+ > Ca2+) and outside (Na+ > K+ > Ca2+ > Mg2+). We explore how TMP could vary for resting/graded/action potentials generation and project a model for impulse conduction in neurons. Outcomes based in murburn bioenergetic equilibriums leading to solubilization of ion-pairs, membrane’s permittivity, protein channels’ fluxes, and proteins’ innate ability to bind/adsorb ions selectively are projected as the integral rationale. We also provide experimental modalities to ratify the projections.
Kritik Karl Marx terhadap kapitalisme dan pengertian sosialis
Authors: Hasym Muchamad
Published: June 2021

Kritik Karl Marx terhadap kapitalisme dan pengertian sosialis
KEBUTUHAN ENERGI DAN ZAT GIZI PADA TUBUH
Authors: Sumarlin Rudi
Published: June 2021

Gizi adalah suatu proses organisme menggunakan makanan yang dikonsumsi secara normal melalui proses digesti, absorpsi, transportasi, penyimpanan, metabolisme, dan pengeluaran zat-zat yang tidak digunakan untuk mempertahankan kehidupan, pertumbuhan dan fungsi normal dari organ-organ serta menghasilkan energi. Akibat kekurangan gizi, maka simpanan zat gizi pada tubuh digunakan untuk memenuhi kebutuhan apabila keadaan ini berlangsung lama maka simpanan zat gizi akan habis dan akhirnya terjadi kemerosotan jaringan. Pada saat ini orang bisa dikatakan malnutrisi. KEP seseorang yang gizi buruk disebakan oleh rendahnya konsumsi energi dan protein dalam makanan sehari- hari. Pada umumnya penderita KEP berasal dari keluarga yang berpenghasilan rendah, tanda- tanda klinis gizi buruk dapat menjadi indicator yang sangat penting untuk mengetahui seseorang menderita gizi buruk. Kebutuhan tubuh akan zat gizi ditentukan oleh banyak faktor. Data komposisi zat gizi bahan makanan yang berhubungan dengan berbagai proses pengolahan belum cukup tersedia, pemeriksaan zat gizi spesifik bertujuan untuk menilai status gizi. Zat gizi yang terdapat pada Angka Kecukupan Gizi (AKG) hanyalah gizi yang penting yaitu energi, protein, vit A, C, B 12, Tiamin, Riboflavin, Niasin, Asam Folat, Kalsium, Fosfor, Zat Besi, Zink, dan Yodium.
SUMBER ZAT GIZI
Authors: Tompo Nurul Inayah
Published: June 2021

Zat gizi utama yang dibutuhkan oleh tubuh adalah protein, karbohidrat, dan lemak. Zat-zat gizi tersebut terutama dibutuhkan untuk metabolisme, membangun dan memperbaiki sel-sel tubuh, dan untuk mendapatkan energi.Selain zat gizi utama tadi, tubuh juga memerlukan mineral dan vitamin untuk mengatur cairan (elektrolit) tubuh, pertumbuhan tulang, pembentukan sel-sel darah, membantu proses metabolisme dan membentuk hormon / enzim.
HOSPITALITAS KRISTEN DAN PERAN ORANG TUA DALAM MEMAHAMI PERGUMULAN REMAJA
Authors: sarapang desna rura
Published: June 2021

Tulisan ini menggambarkan tentang bagaimana seharusnya orang tua berperan dalam mendidik anak remaja mereka, menjalin hubungan atau relasi yang baik bagi mereka, karena seringkali kita jumpai dalam kehidupan kita, di mana orang tua yang terlalu sibuk dengan urusan pekerjaan mereka sehingga anak merasa diterlantarkan dan merasa kurang perhatian dari kedua orang tuanya. Dari sinilah biasanya muncul masalah yang sangat besar, di mana anak-anak mudah terjerumus ke dalam pergaulan bebas seperti mabuk-mabukan, mengkonsumsi obat-obat terlarang, seks bebas, dan masih banyak lagi masalah yang bisa di timbulkan. Melalui tulisan ini akan memperlihatkan bagaimana cara mengatasi masalah-masalah tersebut dan bagaimana seharusnya peran orang tua dalam mendampingi anak-anak mereka. Anak adalah anugerah dari Tuhan, milik pusaka Tuhan. Oleh karena itu, hendaklah orang tua mendidik mereka dengan penuh tanggung jawab.
The VPS35-D620N mutation is associated with Parkinson's disease and can be a target for gene therapy
Authors: Dowaidar Moataz
Published: June 2021

There is evidence that the VPS35 protein impacts degradation of dopaminergic (DA) neuron lifespan and that the D620N mutation is associated with a kind of Parkinson's disease (PD) mimicking idiopathic PD. The incidence of this mutation and the likely pathogenic effects of additional VPS35 variants is unclear. Other unusual VPS35 mutations may put people at risk for Parkinson's disease, but the level of risk has yet to be determined.Due to the functional and genetic links between VPS35 and other PD-associated genes, rare VPS35 variants may be a key extra component in developing the PD phenotype in people with other mutations with inadequate penetration. Genetic association analysis could remedy this issue in the near future.VPS35-associated PD neuropathology is another significant aspect. Since just one D620N mutant carrier has been studied at autopsy to date, limited information is available about the neuropathological spectrum of PD patients with VPS35 mutations. It is yet unknown if neuronal loss in VPS35-related PD occurs just in SNc or affects other brain areas such as locus coeruleus, cortex, hippocampus and other structures. Neuropathology of VPS35-D620N mice models demonstrated severe tau pathology and axonal degradation, but no evidence of SYN inclusions. It's uncertain if PD individuals with VPS35 mutations have the same features.More study on the role of VPS35 in enhancing DA neuron survival is also needed to better understand the metabolic pathways damaged by VPS35 mutations and identify new therapy goals. The D620N VPS35 KI model, paired with the parkinQ311X mouse model, is one of the first monogenic PD models to recapitulate the fundamental PD feature: DA neuronal breakdown in SNc. These mouse models can be used to identify and assess drug targets. Because the neurodegenerative molecular pathways in many types of Parkinson's disease are so similar, drugs that confer neuroprotection in VPS35 models could be studied in other, more common types of Parkinson's disease.
PENGARUH KUALITAS PELAYANAN AKADEMIK TERHADAP KEPUASAN MAHASISWA (studi kasus pada Mahasiswa Manajemen Fakultas Ekonomi UBL)
Authors: Alam Iskandar Ali , Santika Sri
Published: June 2021

Perguruan tinggi harus melakukan langkah antisipasi guna menghadapi persaingan yang semakin kompetitif serta bertanggung jawab untuk menggali dan meningkatkan segala aspek pelayanan yang dimiliki, karena sebuah pelayanan yang dimiliki oleh lembaga tertentu akan menjadi gambaran dari kualitas lembaga tersebut, jika pelayanan yang diberikan menurut masyarakat itu baik maka sebuah lembaga tersebut bisa dikatakan baik. Memiliki rumusan masalah bagaimana gambaran pelayanan akademik FEB terhadap mahasiswa manajemen, Bagaimana gambaran tingkat kepuasan Mahasiswa Manajemen terhadap pelayanan akademik FEB dan Apakah pelayanan akademik berpengaruh terhadap kepuasan mahasiswa manajemen pada FEB. Penelitian ini bertujuan untuk mengetahui kepuasan mahasiswa terhadap pelayanan akademik Fakultas Ekonomi & Bisnis Universitas Bandar Lampung berdasarkan aspek Efisiensi, aspek Assurance, aspek Emphaty, dan aspek Tangible. Penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Populasi penelitian ini adalah mahasiswa manajemen angkatan tahun 2015-2018 sebanyak 1,032 mahasiswa. Teknik pengambilan sampel dilakukan secara propotionate stratified random sampling. Ukuran sampel sebanyak 91 orang. Teknik pengumpulan data menggunakan skala sikap. Teknik analisis data menggunakan uji kecenderungan dan persentase distribusi frekuensi tiap aspek kepuasan. Hasil Penelitian ini menunjukkan: 1) Kepuasan Mahasiswa berdasarkan aspek Efisiensi secara umum memiliki nilai sebesar 73,85 – 77,36 (Kategori Baik), 2) Kepuasan Mahasiswa berdasarkan aspek Assurance secara umum memiliki nilai sebesar 71,87 – 75,85 (Kategori Baik), 3) Kepuasan Mahasiswa berdasarkan aspek Emphaty secara umum memiliki nilai sebesar 70,11 – 83,52 (Kategori Baik dan Sangat Baik), 4) Kepuasan Mahasiswa berdasarkan aspek Tangible secara umum memiliki nilai sebesar 71,87 – 75,85 (Kategori Baik).
Implementing the human artificial chromosome gene therapy platform remains challenging, but continuous animal model research will advance the platform closer to clinical trials
Authors: Dowaidar Moataz
Published: June 2021

A normal degree of ectopic gene expression, infinite retention in target cells without chromosomal integration, minimal risk of cell or neoplastic transformation, and minimal or no immunogenicity are all critical characteristics for vectors employed in gene therapy. HACs were produced and used as autonomous vectors to compensate for genetic defects in mouse and human cell cultures. Bottom-up human artificial chromosomes (HACs) were studied for functional transgene expression in vitro and in vivo mice models. The primary advantages of synthesized alphoid-HACs over top-down HACs are their defined and documented structure, as well as their relative simplicity of modification in adding numerous Cre-lox-type transgen loading sites. The HAC transfer method's efficacy has greatly increased in recent years. Despite significant progress in developing alphoid-HAC-based gene therapy models, the technology still has a number of drawbacks, including low HAC efficiency, complex repeated HAC alphoid-DNA structure, large DNA fragmentation difficulties outside eukaryotic cells, inefficient transfer of chromosomes to target cells, and variable mitotic stability. The quantity and quality of PSC-derived or reversibly immortalized stem/precursor cells that can transplant specific tissues are also critical determinants in the effectiveness of HAC-based tissue replacement therapies. Translating the HAC-based gene therapy platform remains difficult, but ongoing animal model research will move the HAC platform closer to clinical trials.
Hybrid gene therapy designed to fully understand the underlying molecular cancer process may be a feasible option
Authors: Dowaidar Moataz
Published: June 2021

Combination gene therapy properly tailored to a full understanding of the underlying molecular cancer process may be a possible approach. In developing malignancies, the uptake and concentration of tumor suppressors at their target locations may be controlled. As with p53, this intracellular compartmentalization can be done by modulating target gene nuclear transport via imports and exports. Mediating PTMs such as ubiquitin, phosphorylation, and dephosphorylation to impact protein location is also a feasible method. For example, proteasome inhibitors directly or indirectly enhance nuclear localization of proteasome-target proteins such MG-132 and Lactacystin in acute myeloid leukemia PTM regulation is also crucial for managing protein stability; decreased ubiquitination by NEDD8 inhibitors boosts protein stability, which improves mitochondrial localization, although COX-2 inhibitors promote p53 stability and nuclear localisation. PTMs also play a crucial function in binding DNA control. For example, N-terminal phosphorylation and other PTMs alter p53's DNA-binding affinity and selectivity. A careful balance of gene therapy, transport inhibitors, kinase inhibitors, and post-translational modification inhibitors might be a potential alternative. In combined therapy, the p53 nuclear protein displays synergistic activation by enhancing actinomycin-D kinase and inhibiting upregulated-MDM2 from binding through nutlin-3a to p53. Using PEST-NPs as gene treatments requires a pragmatic approach due to their heterogeneous cancer activity.
The Great Replacement Conspiracy: How the Perceived Ousting of Whites Can Evoke Violent Extremism and Islamophobia
Authors: Obaidi Milan , Kunst Jonas R. , Ozer Simon , Kimel Sasha
Published: June 2021

Increased immigration and demographic changes have not only resulted in political pushback, but also in violent attacks against immigrants. Several recent terrorist attacks committed by White supremacists invoke rhetoric around a deliberate attempt to make Whites extinct and replace them with non-Western immigrants. Yet, while it is widely acknowledged among extremism researchers that this perception of orchestrated extinction or replacement has tremendous potential to lead to violent extremism, its consequences have not yet been directly examined. Using the Scandinavian context (e.g., Denmark and Norway), in two correlational studies and one experiment, we provide evidence that this perception is associated with the persecution of Muslims, violent intentions, and Islamophobia. Further, we demonstrate that these associations are mediated by symbolic threats. Conspiracy beliefs that one’s group is being replaced seems to drive hostile intergroup attitudes. We discuss the societal implications of this finding (i.e., generating fear, polarization and hostile public opinion towards immigrants).
Kebutuhan Gizi dan Penilaian Status Gizi
Authors: Hadza Roza Qoni
Published: June 2021

Ada dua metode penilaian status gizi ini yaitu penilaian status gizi langsung yang terdiri dari antropometri, klinis, biokimia, biofisik, dan penilaian tidak langsung terdiri dari survei konsumsi makanan, statistik vital, faktor ekologi. Dengan begitu banyaknya metode penilaian status gizi maka perlu dipertimbangkan faktor untuk memilih metode penilaian yaitu tujuan, unit sampel yang akan diukur, jenis informasi yang dibutuhkan, tingkat reliabilitas dan akurasi yang dibutuhkan, fasilitas & peralatan yang ada, tenaga, waktu, dan dana yang tersedia.
Inflammatory breast cancer remains the most aggressive form of breast cancer. A multimodality therapeutic plan has shown improved survival results
Authors: Dowaidar Moataz
Published: June 2021

Even though inflammatory breast cancer remains the most aggressive form of breast cancer, with the highest rates of morbidity and mortality, other types of breast cancer do exist. In addition to Nneoadjuvant chemotherapy, surgery, and radiation, a multimodality therapeutic plan including these procedures has shown improved survival results for locally advanced disease. Most current research focuses on finding new and novel therapy strategies that can allow people with inflammatory breast cancer to have a longer lifespan. The availability of genomic testing enables early detection of primary and acquired drug resistance as well as the assessment of treatment choices. In addition, an in-depth understanding of inflammatory breast cancer molecular biology will assist in the discovery of critical genomic alterations and oncogenic pathways that contribute to tumor formation and spreading. Future studies will give more valuable information that may be used in clinics to better treatment outcomes.
Deep learning algorithms for scRNAseq analysis have yielded positive results, but there are still more promising ways that need to be developed for regenerative medicine
Authors: Dowaidar Moataz
Published: June 2021

A detailed survey of the use of many deep learning algorithms on scRNAseq data for regenerative medicine was published in this article. Currently, the best deep learning algorithms for scRNAseq analysis have yielded positive results, but there are still more promising ways that need to be developed to better handle technical noise, account for cell expression variability, identify MSCs, and anticipate stem cell type. To gain access to scRNAseq data, these deep learning techniques need to be paired with scRNAseq data. The ability to identify cell types and functions accurately and fast utilizing these algorithms has not yet been made possible. In the study we conducted, we reached the conclusion that further research has to be done into how to apply deep learning algorithms to interpret scRNAseq data, which may be used to better cell therapy and regenerative medicine efforts.
The most useful and commonly available acute rejection surveillance strategies are routine monitoring of myocardial function and donor-specific anti-HLA Abs monitoring
Authors: Dowaidar Moataz
Published: June 2021

Given the complexity of acute rejection (AR) pathogenesis and its vast spectrum of clinical symptoms, no methodology (invasive or non-invasive) can provide all the information needed to identify functionally and prognostically relevant AR, treatment selection, and therapy monitoring early. Only the use of EMBs in combination with non-invasive technologies and methods to detect subclinical changes in myocardial contractile function (e.g., TDI and STE), to detect alloimmune activation (e.g., IM assay, assessment of complement-activating donor-specific anti-HLA Abs (DSAbs), screening of circulating cfdDNA), and to predict the imminent risk of immune-mediated injury (e.g., assessment of complement-activating DSAbs).Searching for both ACR and AMR in all EMBs is a key prerequisite for accurate diagnosis and decision-making in individuals suspected of AR. Close non-invasive allograft surveillance to detect patients at high risk of AR, along with properly planned EMBs (depending on the particular risk profile of the patient), can improve AR surveillance while decreasing rsEMBs. Because rsEMBs are less prevalent after the first post-HTx year and largely symptom-driven diagnostic EMBs, ongoing development of comprehensive, non-invasive technology to monitor both ACR and AMR is of significant importance. This is especially helpful for detecting late subclinical AMR, which would otherwise go unreported.The most useful and commonly available AR surveillance strategies are routine monitoring of myocardial functions utilizing sensitive ECHO techniques (TDI and STE for acute subclinical dysfunction diagnosis) and DSAb monitoring. As a result, early and late use of HTx is strongly suggested. New IM technologies such as T-cell function assays and genomic medicine approaches such as GEP, circulating dd-cfdDNA screening and microRNA assessment are promising non-invasive monitoring tools for future clinical use, but it is still necessary to test the practical value of their individual or combined use for AR detection (including both ACR and AMR), not just for ACR.
KEBUTUHAN ENERGI GIZI DALAM TUBUH
Authors: Yudianti Anita
Published: June 2021

Tubuh memerlukan energi sebagai sumber tenaga untuk segala aktivitas. Energi diperoleh dari makanan sehari-hari yang terdiri dari berbagai zat gizi terutama karbohidrat dan lemak. Energi yang dipergunakan untuk melakukan pekerjaan, dilepaskan dalam tubuh pada proses pembakaran zat-zat makanan. Dengan mengukur jumlah energi yang dikeluarkan itu dapat diketahui berapa banyak makanan yang diperlukan untuk menghasilkannya (Soediaoetama,2000).Kebutuhan energi seseorang adalah konsumsi energi dari makanan yang diperlukan untuk menutupi pengeluaran energi seseorang bila ia mempunyai ukuran dan komposisi tubuh dengan aktivitas yang sesuai dengan kesehatan jangka panjang dan yang memungkinkan pemeliharaan aktivitas fisik yang dibutuhkan secara sosial dan ekonomi (Beck,1993 dan Almatsier, 2001).Sumber energi adalah bahan makanan sumber lemak, seperti lemak dan minyak, kacangkacangan dan biji-bijian. Selain itu bahan makanan sumber karbohidrat, seperti padi-padian, umbi-umbian dan gula murni.Hasil kajian menunjukkan kisaran distribusi energi gizi makro dari pola konsumsi penduduk Indonesia berdasarkan analisis data Riskesdas 2010 adalah 9-14% energi protein, 24-36% energi lemak, dan 54-63% energi karbohidrat Yang belum sebaik yang diharapkan, Yaitu 5-15% energi protein, 25-55% energi lemak, dan 40-60% energi karbohidrat tergantung usia atau tahap tumbuh kembang. (IOM, 2005)
Kebutuhan Energi Gizi Dalam Tubuh
Authors: Hadza Roza Qoni
Published: June 2021

Gizi memiliki peran penting untuk menciptakan Sumber Daya Manusia (SDM) yang sehat, cerdas, tangguh, serta produktif. Untuk itu, upaya peningkatan kualitas gizi seharusnya dimulai sejak usia dini. Angka kecukupan gizi merupakan angka yang menggambarkan kecukupan gizi berdasarkan asupan gizi orang yang sehat. Untuk mengetahui kecukupan gizi, berat badan, tinggi badan, usia, jenis kelamin, energi cadangan bagi anak dan remaja, serta peningkatan pengeluaran energi yang berasal dari asupan pangan memiliki pengaruh yang cukup signifikan.
Depression may be epigenetically controlled by miRNAs making it a diagnostic or gene therapy target
Authors: Dowaidar Moataz
Published: June 2021

Despite decades of animal study and postmortem brain tissue from patients with depression, there are few effective therapeutics for depression, and its mechanism remains unexplained. A complex mixture of genetic and environmental factors leads to depression. In the presence of stressful events, intergenerational transfer of epigenetic markers causes considerable differences between humans and rats. Epigenetic regulation of depression may be regulated by miRNAs and their different characteristics may be affected by both inherited and environmental influences. There are a variety of possible causes that may include genetic and environmental factors as well as their interactions. The diagnosis and treatment of persons with depression will not utilize differentially expressed miRNAs in the peripheral blood or brain tissue as diagnostic or therapeutic markers. Even if the individual miRNAs produced in depression are found, they may not generate meaningful therapeutic effects since histone modification, DNA methylation, and lncRNAs are all implicated in the pathogenic causes of depression, and miRNAs constitute only a small part.Currently, animal models are employed to validate the management of pathogenic pathways in depression research, while human tissue specimen research is of greater value. The bulk of studies on depressed persons focus on blood circulation rather than postmortem brain tissue. This reduces the exploration of pathogenic processes, such as epigenetic regulatory systems like miRNAs. Additionally, depression is diagnosed on the basis of the patient's symptoms, which in turn are influenced by polygenic factors and environmental exposure. More recent advancements, such as the construction of a consortium-based GWAS cohort and a single-cell research methodology, have been made. New advances are making it easier to identify abnormal miRNA mechanisms in depression. The immune system may have a connection to depression as well. Studies have shown that peripheral immune cell therapies are promising. C.G.D. impacts nervous system functioning, according to our results. However, the significance of exosomes in brain function and the pathogenesis of brain disorders remains unknown. Individuals with depression should examine the serum exosome miRNA profile and the underlying biological pathways. Exosomes may be a biomarker for depression diagnosis. This also helps guide future treatment.
G6PD deficiency is a common genetic trait that can protect heterozygotes from dying from malaria
Authors: Dowaidar Moataz
Published: June 2021

G6PD deficiency is a common genetic trait that can protect heterozygotes from dying from malaria (save in the extremely tiny fraction of individuals who have CNSHA). AHA in a G6PD-deficient child or adult, on the other hand, is a medical emergency that, if not treated promptly and properly, can be fatal. Fava bean consumption is the most common cause of AHA: favism is seen in at least 35 countries, with thousands of cases reported each year. Both primaquine and rasburicase have been linked to iatrogenic deaths in the same and other nations, and these deaths may have been averted. Population screening and health education, as well as the cultivation of fava bean types with nil or low vicine and convicine levels, can help to prevent fascism. G6PD biology is eminently interdisciplinary, having served as a model system in biochemical genetics and in understanding how the red cell responds to oxidative stress; a tool for studying X-chromosome inactivation (human development's most spectacular epigenetic event); a tool for studying clonal populations for years; and a pioneer in the molecular genetics of enzymopathies.
Potentials of medicinal nanostructured diamond particles and coatings
Authors: Dowaidar Moataz
Published: June 2021

Particles and coatings can be manufactured utilizing low-cost, scalable processes. In both in vitro and in vivo experiments, unmodified diamond materials displayed good cell biocompatibility. Most current nanostructured diamond research focuses on diamond surfaces for specific cell and tissue interactions. Although the chemical stability of functionalized diamond surfaces has been explored for relatively short periods of time, the functionalized surface's chemical stability while its use in the body deserves additional exploration. In addition, the impact of chemistry (e.g., pH), enzymes, and microorganisms on the functionalized diamond surface's chemical stability must be considered. Moreover, the goals of studies evaluating the biological functionality of nanostructured diamond materials must be better aligned with regulatory requirements (e.g., ASTM International and the International Organization for Standardization) and in vitro and in vivo testing requirements of government agencies (e.g. the U.S. Food & Drug Administration). Because national regulatory authorities generally review medical devices rather than biomaterials, the parameters of in vitro and in vivo research should be closer to the implantation site's biological, chemical and mechanical features. Research on the breakdown of nanostructured diamond devices and the presence of degradation products in surrounding and remote tissues is needed. Thinking about how the sterilizing technique impacts the surface properties and biocompatibility of nanostructured diamond materials is equally significant. As the stability and fate of functionalized diamond particles and surfaces is better known via more in-vitro and in-vivo testing, nanostructured diamond materials are likely to play a greater role in clinical medicine.
Integrating high-throughput genetics and neuroimaging technologies promises greater information on neurobiological anomalies in neurodegenerative diseases
Authors: Dowaidar Moataz
Published: June 2021

The integration of high-throughput genomics and neuroimaging technology has the promise of providing more information about neurobiological irregularities in neurodegenerative illnesses. Transcriptomics-derived connections provide insight into the molecular trajectory of neurodegeneration, prioritizing particular systems and networks while also considering other aspects, including neuropathology and cognition. Causal links between gene expression and brain morphology are unknown, however. If omics systems have a wide impact upstream, they can influence morphological changes identified by MRI. Gene expression is a signal indicating a process already underway in a diseased brain area if it is downstream of structural brain changes. More study on people in the early stages of disease may give insights into the temporal connection between anatomical and expression problems.One such thought is molecular stereotactic propagation. Changes in gene expression may travel across the brain, according to this notion, through tractography trails. They follow the successive pattern of afflicted regions and the temporal distribution of sensitive locations. In addition, cell motility genes are often overexpressed in vulnerable locations. On the other hand, the data on gene expression and its relevance to structural change propagation is still conflicting. The role of immunological processes and motility-related genes in neurodegeneration appears to be validated by expression data.There are no therapies available for neurodegenerative diseases. Symptom development and diagnosis is often delayed due to advanced MRI and clinical stages. Early diagnosis is crucial since therapy interventions should ideally aim at commencing pathogenic processes as soon as possible to avoid the onset of disease and restrict the course of disease. This requires dependable neurodegenerative biomarkers with diagnostic validity. Unfortunately, transcriptomics still has several important limitations. There is a paucity of high-quality expression data encompassing a large number of brain regions, expression data generally collected from healthy persons, comparisons with neuroimaging data from degenerative cohorts, and a lack of consistent approach for transcriptional imaging research. By overcoming this barrier, researchers can uncover prodromal stages of neurodegeneration and therapeutic molecular targets.
The epidemic of COVID-19 prompted widespread use of mRNA vaccinations
Authors: Dowaidar Moataz
Published: June 2021

COVID-19 challenge resulted in huge expenditure in mRNA-lipid-based nanoparticles (LNPs) manufacturing. Hundreds of billions are produced for human use. This is a significant shift, inconceivable only a year ago. If an LNP platform can traverse thick mucus in patients with respiratory difficulties (such as cystic fibrosis) or target extrahepatic tissues in the future, multi-billion-dose procedures are in place to serve a significant number of patients with unusual genetic diseases (>100,000 individuals). Due to LNPs' versatility in delivering genome editing components, a successful strategy might be easily scaled up and employed to successfully eliminate a rare disease with a single treatment.COVID-19 led to widespread usage of mRNA vaccines. For years, academic and industrial scientists have worked intensely to produce these technologies. Although not enough time to analyze the long-term effects of mRNA vaccines, phase III clinical studies of Pfizer/BioNTech and Moderna vaccines showed around 95 percent efficacy and outstanding safety profiles. The COVID-19 outbreak laid the stage for scaling and overcoming distribution limits that would otherwise have taken decades. RNA treatments and nanomedicine as a field will never be the same again, and will take center stage. The Enlightenment Age of the RNA nanotherapeutics sector is coming to an end, and the area is ready for a full-scale industrial revolution.
CRISPR/Cas system research has advanced significantly in biological sciences.There are still many challenges to effective delivery before efficient gene editing may be achieved
Authors: Dowaidar Moataz
Published: June 2021

The CRISPR/Cas system's discovery and execution offer great promise for the treatment of human illnesses and the revolutionization of plant breeding. Despite the fact that CRISPR/Cas system research is well advanced in the life sciences community, there are still considerable barriers to effective delivery that must be overcome before effective gene editing can be achieved. Consider characteristics like specificity, efficacy, and controlled expression while deciding on a plan. Due to the discovery of innovative delivery systems, many of the shortcomings of the CRISPR/Cas system's translatability have been addressed. Because of the rapid growth of delivery mechanisms, a successful translation of CRISPR/Cas technology into medical and agricultural applications is vital, and substantial progress is predicted.
The sigma 1 receptor (S1R) is a potential therapeutic target for the treatment of Huntington's disease
Authors: Dowaidar Moataz
Published: June 2021

During the progression of Huntington's disease (HD), changes in Ca2+ signaling cause neuronal cells to lose a range of functional properties. GABAergic medium spiny neurons (MSNs) are able to prevent Ca2+ imbalance in the early stages of the illness through a number of compensatory strategies. However, as people become older, their neuroprotective potential diminishes due to a decrease in metabolic activity and the generation of Ca2+-buffering proteins. Continuing Ca2+ regulation problems exhaust the cells' compensatory abilities, resulting in a continuous surge in cytosolic Ca2+ and neuronal degeneration.The sigma 1 receptor (S1R) is a potential therapeutic target for the treatment of HD because it regulates a number of cytosolic Ca2+-dependent signaling cascades. S1R activation by selective agonists protects neurons from glutamate excitotoxicity, reduces store-operated Ca2+ entry (SOCE) hyperactivation, and maintains the structural integrity of mitochondria-associated endoplasmic reticulum membranes (MAMs), which is required for synchronizing mitochondrial and endoplasmic reticulum (ER) activity to maintain cell bioenergetics balance. Because of the stability of Ca2+ signaling in neurons, pridopidine, a highly selective S1R agonist, has been demonstrated to protect neurons in cellular and animal models of HD.The synaptoprotective effect of pridopidine is very important since it is found in both cortical and striatal neurons, indicating that pridopidine has a systemic influence on HD therapy. Because synaptic dysfunctions are one of the earliest markers of neuropathology at the cellular level, normalization of Ca2+ balance by pridopidine may prevent disease development at the molecular level at the earliest stages. In this regard, the most significant therapeutic advantage of pridopidine will almost certainly be in preventative treatment, even before the start of the first clinical indications, which will improve neuronal cell compensatory abilities and significantly reduce the progression of HD.
SUMBER-SUMBER ZAT GIZI DAN PENILAIAN STATUS GIZI
Authors: Husain Zulfa
Published: June 2021

Ada dua metode penilaian status gizi ini yaitu Penilaian status gizi Langsung terdiri dari Antropometri, Pemeriksaan Klinis, Biokimia, dan Biofisik, dan Tidak Langsung terdiri dari Survei Konsumsi Makanan, Statistik Vital, Faktor Ekologi.
HOSPITALITAS KRISTEN DALAM MEMBANGUN RELASI REMAJA KRISTEN MASA KINI
Authors: Yusuf Indriyani
Published: June 2021

Adolescent growth is a process in the development of behavior and their daily growth process. Youth need to be trained so they can enter into a changing world, be taught about the word and can have a positive impact on the world. Many teenagers don't know what to do in their youth. There are many challenges experienced by every teenager in the life changes that continue to process within them. The healing of youth is very influential for church growth. Family is one place for teenagers to grow. Through the family, youth behave in accordance with what is taught from the family. In today's more modern times, the relationships are increasingly deviating and exceeding the limits of existing norms. Every association has a very big influence. In this case, the method used is a qualitative method, which is looking for various information regarding appropriate discussions through books and journals. Through the collection of information obtained, the author tries to explain how important it is to build relationships with Christian youth today.
INVESTIGATION OF A POSSIBLE ASSOCIATION BETWEEN KIF1A GENE AND MICROCEPHALY IN ZIKA-DENGUE COINFECTED PATIENT
Authors: PAL ARPAN KUMAR
Published: June 2021

People living in Columbia & brazil are experiencing ZIKA-DENGUE coinfection from last few years. After infecting some patients are asymptomatic, few of them are showing mild symptoms & some of them are experiencing serious neurological issues. The situation become more challenging if any pregnant woman coinfected by DENGUE-ZIKA at the same time, the neonatal may develop microcephaly (A neurological developmental disorder). The reason behind this is not clear yet & no such treatment is established to treat the neuronal complications. It is established that microcephaly is a genetic disease & KIF1A gene is responsible for this. I would like to investigate about this particular phenomenon and will try to give a new concept, which can be used for future treatment.