bluuebunny/crossref_metadata_2025 huggingface dataset:
The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
Authors: Radonjic Katarina , Stojic Isidora , Zivkovic Vladimir , Srejovic Ivan , Jeremic Nevena , Jakovljevic Vladimir , Djuric Dragan , Novokmet Slobodan
Published: June 2017

Interest for the clinical application of transition metal complexes as chemotherapeutic agents initially started with discovery of cisplatin. Despite the remarkable clinical success, cisplatin treatment is limited due to its resistance and side effects. Over the last 40 years, numerous transition metal complexes were synthesized and investigated in vitro and in vivo in order to establish a metallopharmaceutical that will exert less toxicity and equal or higher potency. We have compared the cardiotoxicity of 2 platinum complexes, one ligand, and a starting salt for complex synthesis using an experimental model of an isolated, perfused rat heart according to the Langendorfftechnique. The cardiotoxicity was assessed by comparison of oxidative stress induced following the perfusion of the following compounds: Dichloro(1,2-diaminocyclohexane)platinum(II), cisplatin, potassium-tetra-chloroplatinum(II) and 1,2-diaminocyclohexane, which were perfused at increasing concentrations from 10−8 to 10−4 M for 30 minutes. The oxidative stress was assessed by determination of superoxide anion radical, hydrogen peroxide, thiobarbituric acid reactive substances, and nitric oxide from the coronary venous effluent. Our results showed that the levels of oxidative stress parameters were not significantly affected by perfusion with all the tested compounds and were not dose-dependent. These results could be of importance to further investigations concerning the effects of platinum-based potential anticancer drugs on the heart.
A Case Report of Female Patient with Laryngeal Granuloma
Authors: Simovic Sladjana , Vulovic Tatjana Sarenac , Stojanovic Jasmina , Zivanovic Sandra , Koravovic Mladen
Published: June 2017

The aim of this case report is to present the laryngeal granuloma in 23 year old female patient. Case outline: The 23 year old female was admitted for examination, because of long lasting, progressive hoarseness. In anamnesis, we found that she has undergone general anesthesia for 8 times, in the early childhood. We performing direct laryngoscopy with complete otorhinolaryngologic examination, rigid endovideostroboscopy and the large granuloma of the larynx was found. Conclusions: Laryngeal granuloma of vocal cords affected mainly men, except for cases associated with laryngeal intubation. We should keep in mind that postintubation laryngeal granuloma might develop after tracheal intubation, so care must be taken to avoid the potential complication.
The Autonomic Repercussions of Fetal and Maternal Interaction in Pre-eclampsia
Authors: Lakhno Igor Victorovich
Published: June 2017

Pre-eclampsia (PE) is one of the severe complications of pregnancy that leads to fetal deterioration. The aim of the investigation was to determine the role of maternal respiratory sinus arrhythmia (RSA) in regulation of fetal circulatory system in case of healthy pregnancy and in PE.

The investigation of maternal and fetal HRV and umbilical venous blood flow velocity spectral analysis in 106 patients at 34-40 weeks of gestation was performed. 30 of them had healthy pregnancy and were involved in the Group I. In Group II 44 pregnant women with mild-moderate PE were observed. 32 patients with severe PE were monitored in Group III. The maternal sympathetic overactivity modulated HRV in PE. The suppression of RSA was explored in preeclamptic patients. The Doppler spectrograms of the umbilical veinous blod flow had the oscillatory peak with a frequency about 0.5 Hz. The above peak characterized the participation of the maternal RSA in fetal hemodynamics. Strong relationship between maternal RMSSD and amplitude of RSA associated peak, maternal and fetal RMSSDs was found in healthy pregnancy. No considerable relationship was revealed between the maternal RMSSD and the amplitude of 0.5 Hz frequency peak, the maternal and fetal RMSSDs in the patients with severe PE. The maternal RSA propagated its influence on the fetal umbilical venous blood flow and the fetal autonomic nervous regulation in normal gestation. The control of fetal hemodynamics diminished in the mild-moderate PE and even disappeared in severe PE.
Overdiagnosis: An unrecognised and growing worldwide problem in healthcare
Authors: Brodersen John
Published: June 2017

Overdiagnosis is the diagnosis of deviations, abnormalities, risk factors, and pathologies that in themselves would never cause symptoms (this applies only to risk factors and pathology), would never lead to morbidity, and would never be the cause of death. Therefore, treating an overdiagnosed condition (deviation, abnormality, risk factor, pathology) cannot, by definition, improve the patient’s prognosis, and can therefore only be harmful.

Overdiagnosis is an extremely harmful and big problem all over the world, and the problem is increasing. This is especially the case in high-income countries, where more sensitive tests, more testing, more screening and earlier diagnosis is in focus, and more of the same will be implemented in the future. Moreover, disease definitions have been and are still being widened, plus thresholds for treating, e.g. risk factors, have been and are still being lowered. Finally, disease mongering is growing, because it is cheaper and faster to invent new “diseases” than new pharmaceutical drugs.

From the definition of overdiagnosis it can be reasoned that a patient who has been correctly diagnosed and a person who has been overdiagnosed can have the same kind of pathologies. Therefore, at the level of the individual person or patient it can never be verified whether he or she has in fact been correctly diagnosed or overdiagnosed. Therefore, the complexity, dilemmas and pitfalls in understanding what overdiagnosis really is so succinctly captured by this quote from the Danish philosopher S⊘ren Kirkegaard (1813-55): ‘Life can only be understood backwards; but it must be lived forwards’.
Smoking behaviors in Kosova: Results of steps survey
Authors: Gashi Sanije , Berisha Merita , Ramadani Naser , Gashi Musli , Kern Josipa , Dzakula Aleksandar , Vuletic Silvije
Published: June 2017

Introduction

Tobacco use continues to be the leading global cause of preventable death. Most of these deaths occur in low and middle-income countries, and this trend is expected to widen further over the next several decades. The overall objective of the study is to describe and analyse the smoking behaviours of adults in Kosova.

Methods

According to the STEPs methodology, 6,400 respondents, aged 15 - 64 years, are selected randomly within each sex and 10-year age-group. Out of 6,400 participants, 6,117 were selected, which is approximately 95.6%.

Results

The prevalence of smoking was higher among males (37.4%) compared with females (19.7%). In all age groups, the prevalence of smoking was higher among males compared with females. Regarding the age group of 15 - 24 years, the prevalence of smoking was 16.0%, but in the age group of 25 - 34 years, it nearly doubled to the rate of 31.9%. We have a smaller increase in the age group of 35 - 44 years, and after the age of 45, it falls gradually.

Conclusions

The prevalence of smoking in Kosova is high compared with other countries in Eastern Europe. In future decades, Kosova will face a high probability of an increased burden of smoking-related diseases.
Nasopharyngeal carriage of Streptococcus pneumoniae and serotypes indentified among nursing home residents in comparison to the elderly and patients younger than 65 years living in domestic environment
Authors: Kolšek-šušteršič Maja , Beg Krasnič Andreja , Mioč Verica , Paragi Metka , Rifel Janez
Published: June 2017

Introduction

In Slovenia, there is little data available on pneumococcal vaccination rates and no data on asymptomatic NPCR and serotypes in the population of nursing home residents in comparison to the elderly living in domestic environment, therefore the goal was to gain these data.

Methods

A cross sectional epidemiological study was performed. Nasopharyngeal swabs from 151 nursing home residents, 150 elderly living in domestic environment, and 38 adults less than 65 years old were collected twice (in two consecutive years). The swabs were analysed for pneumococcal identification and serotyping. Patient data were collected from medical files and medical history.

Results

No statistically significant differences in NPCR were seen between compared groups in two consecutive years. An average NPCR in two consecutive years in nursing home residents was 1.45%, in the elderly living in domestic environment 0.85%, and in adults less than 65 years old 7.05%. Serotypes identified among nursing home residents were 6B and 9N, among the group of elderly living in domestic environment, 6A and among adults less than 65 years old, 35F, 18C and 3. Pneumococcal vaccination rates were low (3.3% in nursing home residents, 6% in the elderly from domestic environment and 0% in the group of adults less than 65 years old).

Conclusions

Our data suggests that NPCR and the proportion of people vaccinated with pneumococcal vaccine among the elderly are low. We identified different serotypes in all groups, only one person was a chronic carrier (serotype 35F).
Knowledge about blood-borne pathogens and the prevalence of needle stick injuries among medical students in Serbia
Authors: Marusic Vuk , Markovic-Denic Ljiljana , Djuric Olivera , Protic Dragana , Dubljanin-Raspopovic Emilija
Published: June 2017

Introduction

Medical students are mainly exposed to needle stick and sharp object injuries in the course of their clinical activities during studying. They are at high risk due to their undeveloped skills, restricted clinical experience, lack of knowledge and risk perception. The objectives of this study were to determine the prevalence of needle stick injuries of the fourth and final year medical students, and to estimate their knowledge about blood-borne pathogens disease transmission and standard precautions.

Methods

This cross-sectional study was conducted at the Faculty of Medicine, in February 2014. The students were invited to self-administer a questionnaire of 26 closed questions prepared for this study.

Results

The questionnaire was filled in and returned by 637 students. The prevalence of needle sticks and sharp object injuries was 29.5%. Needle stick injuries were the most common type of accidents, more frequent among the fourth compared to the sixth year students (p=0.002). The majority of accidents occurred in patient rooms (53%) and the emergency department (15%). 54% of participants reported an accident to the responsible person. Students without accidents had a significantly better perception of risk (3.79 vs. 3.35; p<0.05). Out of the total participating students, only 16.6% (106/637) received all three doses of Hepatitis B vaccination, while 16.2% were partially vaccinated.

Conclusions

There is a need for additional theoretical and practical education of our students on blood exposure via accidents, raising the awareness of the necessity of hepatitis B vaccination, and introducing the unique/comprehensive procedure for accident reporting for students and healthcare workers in the entire country.
Contingent High-Skilled Work and Flexible Labor Markets. Creative Workers and Independent Contractors Cycling Between Employment and Unemployment
Authors: Menger Pierre-Michel
Published: June 2017

Flexibility in highly skilled jobs combines the characteristics of the secondary and the professional labor market, which oblige to revise the separation between salaried work and self-employment. Two cases are studied: the employment system of artists and technical workers in the performing arts and the work of independent contractors mediated by umbrella firms. An analysis of the French labor market shows how “flexicurity” may work, but also how its books may get unbalanced, as employers learn to make strategic use of unemployment insurance.
Being a Music Performer in French Speaking Switzerland: Relationships to Work and Employment
Authors: Perrenoud Marc
Published: June 2017

Ordinary musicians are a relatively hard to find population. Based on the results of the research project Musicians’ LIVES carried out between 2012 and 2015, this article presents the working situation of performing musicians in French speaking Switzerland. We compare the social characteristics of the musicians with the active population. We then analyse musicians’ relationship to work and examine the composition of their income. Three main ways of being a musician in Western Switzerland are presented: the “craftsman,” the “teacher” and the “artist.”
The usefulness of soil-agricultural maps to identify classes of soil truncation
Authors: Pindral Sylwia , Świtoniak Marcin
Published: June 2017

Soil erosion led to the severe transformations of the soil cover of young morainic areas of northern Poland. Main alterations are connected with soil truncation on summits and in upper part of slopes, whereas at foot slopes and within depressions colluvial material is accumulated. Information and knowledge about the extent or intensity of erosion are mainly derived from sophisticated geospatial models or laborious field works. To reduce the effort associated with development of studies on erosion the use of easily available cartographic sources is required. The main aim of the paper is an elaboration of key to reinterpret information taken from soil-agricultural maps in the context of determining the degree of pedons truncation. The study is based on a comparison of the properties of soils representing various classes of erosional alterations with the data on existing maps. The correlation between descriptions recorded in the form of cartographic symbols with properties of pedons divided into several classes of vertical texturecontrast soil truncation and results from potential erosion maps was elaborated. The application of developed interpretative principles allows calculating the share of soil truncation classes within investigated area. The five test plots (each - 1 km2) were located along the north slopes of Noteć Middle Valley and Toruń Basin. The proposed interpretation of soil-agricultural maps reveals their significant value in studies on extent and degree of erosional alterations recorded in soil cover.
Variability of morphological, physical and chemical properties of soils derived from carbonate-rich parent material in the Pieniny Mountains (south Poland)
Authors: Kowalska Joanna , Kajdas Bartłomiej , Zaleski Tomasz
Published: June 2017

Carbonate-rich soils are characterized by great diversity in content of carbonate and non-carbonate mineral substances in soil substrate which largely influences soil properties. The study presents the analysis results of four soil profiles located at the area of Pieniny National Park. The aim of this study was to characterize and classify the soils developed from the mixture of carbonate and carbonate-rich rock material, formerly classified as pararendzinas. It was achieved by determination of morphological, physical, and chemical properties, as well as mineralogical composition of selected carbonate-rich soils occurring in the Polish part of the Pieniny Mts. Soils were classified as typical chernozemic rendzina (P1), typical eutrophic brown soils (P2, P4), as well as typical pararendzina (P3) according to Polish Soil Classification (2011).

The parent material of studied soils P1, P2 and P4 were slope covers, with a dominant share of sandstone and minor share of limestone, whereas soil P3 was formed from variegated shale cut with multiple calcite veins. Soils were characterized by stable aggregate structure: crumby, angular blocky and subangular blocky. They were medium or strong skeletal, mostly with loam texture with great share of silt fraction. CaCO3 content in genetic horizons ranged from 0.0 to 703.0 g·kg-1. The reaction of studied soils was from weakly acidic to alkaline. Analysed soils were characterized by very high base saturation. Among determined exchangeable cations, Ca2+ ions had the biggest share in all analysed profile. High base saturation, as well as high content of calcium carbonate was accompanied by content of organic matter and percentage content of clay fraction. Taking into consideration determined chemical and physical properties, it can be found that investigated soils were influenced by not only the in-situ weathering material but also by rock material which have been transported and deposited as a result of slope processes. Furthermore, the lack or lower content of CaCO3 in surface and middle part of analysed soil profiles was most likely a result of the impoverishment of rock material during the transport on the slope.
Optimization Design and Experimental Study of a Two-disk Rotor System Based on Multi-Island Genetic Algorithm
Authors: Huang Jingjing , Zheng Longxi , Mechefske Chris K , Han Bingbing
Published: June 2017

Based on rotor dynamics theory, a two-disk flexible rotor system representing an aero-engine with freely supported structure was established with commercial software ANSYS. The physical model of the two-disk rotor system was then integrated to the multidisciplinary design optimization software ISIGHT and the maximum vibration amplitudes experienced by the two disks when crossing the first critical speed were optimized using a multi-island genetic algorithm (MIGA). The optimization objective was to minimize the vibration amplitudes of the two disks when crossing the first critical speed. The position of disk 1 was selected as the optimization variable. The optimum position of disk 1 was obtained at the specified constraint that the variation of the first critical speed could not exceed the range of ±10 %. In order to validate the performance of the optimization design, the proof-of-transient experiments were conducted based on a high-speed flexible two-disk rotor system. Experimental results indicated that the maximum vibration amplitude of disk 1 when crossing the first critical speed declined by 60.9 % and the maximum vibration amplitude of disk 2 fell by 63.48 % after optimization. The optimization method found the optimum rotor positions of the flexible rotor system which resulted in minimum vibration amplitudes.
Did Tertullian Read Marcion in Latin? Grammatical Evidence from the Greek of Ephesians 3:9 in Marcion’s Apostolikon as Presented in the Latin of Tertullian’s Adversus Marcionem
Authors: Lang T. J.
Published: June 2017

In his landmark work on Marcion, Adolf von Harnack became the first modern scholar to propose that Tertullian only knew Marcion’s
Subject-verb agreement in German in bilingual children with and without SLI
Authors: Rothweiler Monika , Schönenberger Manuela , Sterner Franziska
Published: June 2017

We investigated the acquisition of subject-verb agreement (SVA) in German based on spontaneous speech data
from both typically developing (TD) and language-impaired (SLI) children learning German as a second language (L2),
and from language-impaired monolingual children. Rothweiler et al. (2012) suggested that SVA is
vulnerable in SLI. The intent of our study was to determine whether TD child L2 learners (cL2) in contrast to children
with SLI do not have difficulties with SVA. Many studies report that cL2 acquisition can differ from monolingual (L1)
acquisition and that the differences look similar to those of impaired L1 learners, which makes it difficult to distinguish
cL2 learners who have SLI from those who do not. If such similarities were to be found in the acquisition of SVA in the
two bilingual groups, SVA would be ruled out as a possible marker of SLI in cL2 learners. Three groups of children
were compared: six Turkish-German early cL2 learners without SLI, and twelve children with SLI – six monolingual
German children and six Turkish-German early cL2 learners. As in Rothweiler et al. (2012), all children
were advanced learners and were therefore expected to have acquired SVA. We found that the unimpaired early cL2
learners had indeed successfully acquired SVA. In contrast, neither the monolingual nor the bilingual children with SLI
succeeded in reliably producing correct SVA.
Two iodine-rich (dimethylphosphoryl)methanaminium iodides
Authors: Reiss Guido J.
Published: June 2017

The reaction of dpma (dpma=(dimethylphosphoryl)methanamine) with hydroiodic acid in the presence of an excess of elemental iodine gives red coloured crystals of (dpmaH)3(H3O)I4·1/2I2 (1) as the main product and a small amount of a by-product (dpmaH)2[I3]2·dpma (2). Single crystal structure determinations on both compounds were carried out. In the crystal structure of 1 (space group P3̅, a=12.2166(3) Å, c=10.8788(4) Å, R
gt(F)= 0.0224, wR
ref(F
2)=0.0377), six symmetry related dpmaH+ cations and iodide anions, both located in general positions, form a cage through NH···I hydrogen bonds. These cages are connected to neighbouring ones by H3O+ cations by means of strong OH···O hydrogen bonds, thereby constructing a 2-dimensional network perpendicular to the c direction. In the center of each cage a three-fold disordered I2 molecule is present. This disorder is a consequence of space group symmetry. Each iodine molecule forms two halogen bonds to two adjacent iodide anions (Δ(I···I)=3.2449(7) Å) formally resulting in an almost linear I4
2− anion. The second iodide counter anion is located alternatively beneath and below the H3O+ cation and is not involved in any stronger hydrogen bonding interaction. The dominant feature of the crystal structure of 2 (space group C2/c, a=28.885(5) Å, b=10.6854(15) Å, c=20.659(4) Å, β=110.64(2)°, R
gt(F)=0.0776, wR
ref(F
2)=0.1410) is a ladder substructure formed by dpmaH cations and neutral dpma molecules via NH···O and NH···N hydrogen bonds. Triiodide counter anions occupy gaps in the ladder. A characteristic Raman signal representing the iodine molecule in the Raman spectrum of 1 is shifted to lower wavenumbers (173 cm−1). It corresponds to an iodine molecule trapped in the cage of a hydrogen bonded network forming medium strong halogen bonds. The Raman spectrum of 2 shows the typical bands of a weakly connected I3
− anion.
Two new pyrrolo[2,3-d]pyrimidines (7-deazapurines): ultrasonic-assisted synthesis, experimental and theoretical characterizations as well as antibacterial evaluation
Authors: Vazirimehr Simin , Davoodnia Abolghasem , Beyramabadi S. Ali , Nakhaei-Moghaddam Mahboobeh , Tavakoli-Hoseini Niloofar
Published: June 2017

Two new pyrrolo[2,3-d]pyrimidines (7-deazapurines) were synthesized in high yields by the reaction of 2-amino-1-methyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile with triethyl orthoformate followed by cyclocondensation with methyl or benzyl amine in refluxing glacial acetic acid or using ultrasonic irradiation containing a catalytic amount of glacial acetic acid at 60°C. For each product, the correct structural isomer was identified using the FT-IR, 1H NMR, 13C NMR, 2D nuclear Overhauser effect spectroscopy spectral and microanalytical data together with comparison of the experimental and calculated chemical shifts at the B3LYP/6-31+G(d,p) level of theory. Furthermore, the synthesized compounds were evaluated for their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram-negative bacteria (Escherichia coli) by the agar dilution method using 24-well microtiter plates.
Ignition by Electrical Discharges
Authors: Markus Detlev , Essmann Stefan , Kummer Johann-Robert , Shekhar Rajiv , Uber Carsten , Gerlach Udo , Maas Ulrich
Published: June 2017

The ignition of combustible/air mixtures by electrical discharges includes several physical and chemical processes. In process safety often the total available electrical energy is taken as a risk measure. However, to get a more detailed insight in the ignition process, also energy losses to the surrounding have to be considered. Additionally, for specific discharges not only the dissipation leading to thermal heating is of importance. Especially in the case of non-equilibrium plasma, a specific fractional amount of the discharge energy is used for electron impact dissociation, excitation, and ionization reactions, producing active radicals and ions during the discharge phase. While the electrical energy can be measured easily, it is difficult to determine energy losses. In this paper three different electrical discharges are examined experimentally and numerically to yield a better understanding of the ignition by electrical discharges.
Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
Authors: Suckling Richard J , Korona Boguslawa , Whiteman Pat , Chillakuri Chandramouli , Holt Laurie , Handford Penny A , Lea Susan M
Published: June 2017

Recent data have expanded our understanding of Notch signalling by identifying a C2 domain at the N‐terminus of Notch ligands, which has both lipid‐ and receptor‐binding properties. We present novel structures of human ligands Jagged2 and Delta‐like4 and human Notch2, together with functional assays, which suggest that ligand‐mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. Comparisons between the Jagged and Delta family show a huge diversity in the structures of the loops at the apex of the C2 domain implicated in membrane recognition and Jagged1 missense mutations, which affect these loops and are associated with extrahepatic biliary atresia, lead to a loss of membrane recognition, but do not alter Notch binding. Taken together, these data suggest that C2 domain binding to membranes is an important element in tuning ligand‐dependent Notch signalling in different physiological contexts.
The Effect of Best First and Spreadsubsample on Selection of a Feature Wrapper With Na�ve Bayes Classifier for The Classification of the Ratio of Inpatients
Authors: Wijaya M Rizky , Saptono Ristu , Doewes Afrizal
Published: June 2017

Diabetes can lead to mortality and disability, so patients should be inpatient again to undergo treatment again to be saved. On previous research about feature selection with greedy stepwise forward fail to predict classification ratio inpatient of patient with the result of recall and precision 0 on data training 60%, 75%, 80%, and 90% and there is suggestion to handle unbalanced class data problem by comparison of data readmitted 6293 and the otherwise 64141. The research purposed to know the effect of choosing the best model using best first instead of greedy stepwise forward and data sampling with spreadsubsample to resolve unbalanced class data problem. The data used was patient data from 130 American Hospital in 1999 until 2008 with 70434 data. The method that used was best first search and spreadsubsample. The result of this research are precision found 0.4 and 0.333 on training dataset 75% and 90% with best first method, while spreadsubsample method found that value of precision and recall is more significantly increased. Spreadsubsample has more effect with the result of precision and recall rather than using best first method.
Efficacy of lenvatinib in a patient with anaplastic thyroid cancer
Authors: Oishi Kazuyuki , Takabatake Daisuke , Shibuya Yuichi
Published: June 2017

We experienced a case of an 82-year-old woman who presented to our hospital with a 1-month history of dysphagia and dyspnea. Cervical contrast-enhanced computed tomography revealed diffuse thyroid neoplasms causing significant tracheal stenosis with tumors, particularly of the superior mediastinum, which were associated with an embolism of the brachiocephalic vein and suspected invasion to the bilateral common carotid arteries. Anaplastic thyroid cancer (ATC) was diagnosed by fine-needle aspiration; thus, emergency tracheostomy and gastrostomy were performed. We made a definitive diagnosis of ATC (T4bN0M0 Stage IVB) and initiated continuous lenvatinib administration at 24 mg/day. Although several adverse events occurred, the tumor size reduced remarkably over a short period. However, the patient died from rupture of the common carotid artery 30 days after treatment initiation. Here, we report our experience with lenvatinib therapy for ATC and include a literature review.

Learning points:

Lenvatinib is extremely effective for ATC.

Lenvatinib has a much greater cytoreductive effect than traditional therapies, but it needs dose reduction or withdrawal because of treatment-related side effects.

Lenvatinib may cause treatment-related carotid blowout syndrome, resulting in death for patients with invasion to the carotid artery.
Benefits from the remote monitoring of railway assets
Authors: Armstrong John , Preston John
Published: June 2017

Railway infrastructure already has some ‘smart’ characteristics, in that it ‘knows’ where trains are located and can sometimes detect track and other equipment faults. There is considerable scope to increase these capabilities. There is also a significant and urgent need for such improvements: railways have limited operational flexibility and face increasing passenger and freight traffic demand on existing infrastructure. The reliable provision of additional capacity requires improved system ‘self-knowledge’ for traffic control and management purposes, as well as for system reliability and safety. The use of smart infrastructure for fault prediction and the guidance of preventive maintenance helps to maintain operational capacity. This approach also helps to reduce track access requirements for traditional maintenance and renewals activities, thus increasing network availability and total capacity. Climate change presents the railway industry with significant challenges, notably in terms of flooding and earthworks failures resulting from increased rainfall intensity. Smart infrastructure includes the prediction and monitoring of such events to maintain safety and enable the timely implementation of operational contingency plans. This paper draws upon a range of sources to identify the needs for and potential benefits of increased deployment of smart infrastructure and other assets on railways in Britain and elsewhere.
How Have the Fed's Three Rate Hikes Passed Through to Selected Short-term Interest Rates?
Authors: Anderson Alyssa , Ihrig Jane , Styczynski Mary-Frances , Weinbach Gretchen
Published: June 2017

Since December 2015, the Federal Open Market Committee (FOMC) has increased the target range for the federal funds rate by 25 basis points three times, bringing the target range from 0 to 25 basis points in late 2015 to 75 to 100 basis points in March 2017. This Note examines how this cumulative 75 basis point increase in the target range for the Fed's policy rate has transmitted to other short-term interest rates.
SATISFACCIÓN LABORAL Y EL CLIMA ORGANIZACIONAL DE LAS PRINCIPALES UNIVERSIDADES SUCREÑAS
Authors: Rojas Martinez Claudia Patricia
Published: June 2017

El presente artículo es resultado de una investigación que se realizó con el objetivo describir los elementos que conforman la satisfacción laboral y determinar cómo este factor influye en el clima organizacional de los empleados de las principales universidades sucreñas; la investigación se llevó a cabo en las principales universidades de Sucre (Colombia) que cuentan con sede propia tomándose para ello una muestra de 120 docentes.. Los resultados referentes a las condiciones laborales no son las mejores, además con respecto a la estabilidad laboral, no se garantiza a los colaboradores su permanencia en la organización; con relación a la autorrealización, no hay apoyo suficiente para su crecimiento profesional y las capacitaciones son. Para dar solución a dicha situación se concluye que es necesario implementar estrategias direccionadas a brindar más motivación a los colaboradores organizando capacitaciones de acuerdo al desempeño que se quiera fortalecer en cada docente de esta manera se fundamentar así el clima organizacional y la satisfacción laboral factores que determinen el grado de bienestar de los individuos. ABSTRACTThis article has as objective to describe the elements that make up the job satisfaction and determine how this factor influences the organizational climate of the employees of the main universities sucreñas; the research was conducted at major universities with its own headquarters of the department of Sucre, taking a sample of 120 teachers. Regarding working conditions are not the best, and with respect to job security is not guaranteed to reviewers their stay in the organization in relation to the self, there is sufficient support for their professional growth and training are scarce. To provide a solution to these situations it is concluded that it is very necessary to implement strategies routed to provide more motivation to the collaborators, constantly training according to the performance that you want to strengthen in each teacher and in this way substantiate to the organizational climate and job satisfaction as factors that determine the degree of well-being that the individual experience.
Narrativa de la Memoria como elemento de formación comunitaria en una población de Quito
Authors: Campo Araúz Lorena
Published: June 2017

En este texto se presentan las reflexiones generadas a partir de la experiencia del proyecto de investigación La memoria como elemento de formación comunitaria en Lloa, de la Universidad Politécnica Salesiana. Se muestran distintas narrativas registradas entre la población del sector y algunas reflexiones alrededor de ellas desde la  propuesta de Maurice Halbwachs y Henri Bergson, de manera que quienes lo revisen puedan reflexionar sobre las distintas narrativas registradas alrededor del tema del suicidio y las implicaciones ético-políticas que implica un proceso de investigación de este tipo. Al final, se reconoce que sobre Lloa existen narrativas contenidas en memorias plurales. Cada relato va conformando el sentido comunitario, real e imaginado de la zona con múltiples formas de relatar y construir las memorias de un pueblo marcado por la cercanía al volcán Guagua Pichincha y últimamente la sombra del suicidio.
LA RENOVACIÓN DE LAS IZQUIERDAS EN COLOMBIA: ¿UNA CUESTIÓN DE JÓVENES? Reflexiones desde la política del acontecimiento.
Authors: Forero Nicolás Aguilar
Published: June 2017

En el presente artículo de reflexión se retoman los planteamientos de Mauricio Lazzarato en torno a la lógica de la diferencia y la política del acontecimiento para destacar su importancia en el camino hacia la renovación de las izquierdas en Colombia. De igual forma, se argumenta que los procesos de renovación de las izquierdas en este país en lugar de  orientarse hacia la búsqueda de la unidad y el éxito en la política electoral, pueden nutrirse de las experiencias de acción colectiva juvenil que desde el año 2011 han desplegado formas de organización y relacionamiento alternativas, en donde la comunicación, la confianza, la colaboración y la construcción de lo común han desempeñado un rol crucial.  
Chu's-10 Metal Solution v2
Authors: Steven Wilhelm Dr.
Published: June 2017

Please contact Dr. Steven Wilhelm (wilhelm@utk.edu) for additional information regarding this protocol.
MA Media v1
Authors: Steven Wilhelm Dr.
Published: June 2017

Please contact Dr. Steven Wilhelm (wilhelm@utk.edu) for additional information regarding this protocol. Adapted from Ichimura, T. 1979 2. Isolation and culture methods of algae. 2.5.B. Freshwater algae [2. Sôrui no bunri to baiyôhô. 2.5.B. Tansui sôrui]. In Methods in Phycological Studies [Sôrui Kenkyûhô], Eds. by Nishizawa, K. & Chihara, M., Kyoritsu Shuppan, Tokyo, p. 294-305 ( in Japanese without English title ).
CT Media v1
Authors: Steven Wilhelm Dr.
Published: June 2017

Please contact Dr. Steven Wilhelm (wilhelm@utk.edu) for additional information regarding this protocol. Modified from: Watanabe, Makoto M. "Fresh-and salt-water forms of Spirulina platensis in axenic cultures." Bull. Jpn. Soc. Phycol. 25 (1977): 371-377.
BG-11 Media v3
Authors: Steven Wilhelm Dr.
Published: June 2017

Please contact Dr. Steven Wilhelm (wilhelm@utk.edu) for additional information regarding this protocol. Adapted from the original publication Rippka, R., DeRulles, J., Waterbury, J. B., Herdman, M. & Stanier, R. Y. Generic assignments, strain histories and properties of pure cultures of cyanobacteria. Journal of General Microbiology 111, 1-61 (1979).
Protocol for the computation of figures 7 and 8 of ""High precision detection of conserved segments from synteny blocks" v2
Authors: MEX Lucas Joseph , Hugues Roest Crollius not provided
Published: June 2017

This protocol was used to compute figures 7 and 8 in the manuscript : 'High precision detection of conserved segments from synteny blocks' submitted at Plos ONE.
纺织染色废水回用治理设计要点分析
Authors: 姜 素华
Published: June 2017

印染行业用水量大，印染废水污染物种类多，水质复杂且水质波动较大，直接排放不仅造成水资源浪费，而且会对环境造成污染。 印染废水在物化和生化处理后，再选择适当技术进行深度处理，以达到中水回用标准，既可以减少水污染、节约水资源，还可以为企业减少运行 成本 。本文就基于此通过实际工程案例分析，对我国纺织企业印染废水回用治理设计进行了分析。
环保行业里的供配电设计
Authors: 张 玉珊
Published: June 2017

21 世纪，科技的发展造就各种高新科技技术的应用，给各行业都带来了高效率高质量的产业发展。 但同时也出现了严重的污染问题， 这 使得我国的环保观念意识日益增强。随着经济建设的快速发展，用电需求量逐渐增加，对于供配电系统产生了巨大的压力，为了积极的响应我 国低碳 环保的号召，在供配电系统实施环保措施具有重要的意义。
提高农业防灾抗灾能力
Authors: 孙 哲
Published: June 2017

近年来我国农业和全球经济之间的关联程度不断提升，国际农产品市场对于我国所造成的影响正在持续深化，农业经济在我国农业 发展 过程中具有了愈来愈越重要的作用。 农业经济要想取得发展，极其容易受到农业自然灾害的影响。为此，必须有针对性采取各种行之有效的 措施，尽 可能地减少不利影响，进而更好地推动农业经济的发展。鉴于此，本文对如何提高农业防灾抗灾能力进行了分析探讨，仅供参考
Debata parlamentarna poświęcona rozgraniczaniu nieruchomości jako płaszczyzna wymiany idei politycznych i prawnych w Królestwie Polskim
Authors: Kania Rafał
Published: June 2017

-
Przyczynek do badań nad służbą Polaków z ziem litewsko-białoruskich w administracji cywilnej Cesarstwa Rosyjskiego w XIX wieku
Authors: Korybut-Marciniak Maria
Published: June 2017

-
Между личным пространством и явностью жизни. Дворянки в Польском Королестве на рубеже XIX и XX веков
Authors: Kostrzewska Ewelina Maria
Published: June 2017

-
„Katechizm za sześć centów…” Jan kardynał Puzyna wobec kwestii socjalnej
Authors: Marchel Sławomir
Published: June 2017

-
Pierwsza Pomorska Wystawa Rolnictwa i Przemysłu w Grudziądzu (1925 r.) w świetle lokalnych artykułów prasowych
Authors: Knyspel-Kopeć Renata
Published: June 2017

-
Dyskusje naukowe wokół ewakuacji Ołtarza Mariackiego w latach II wojny światowej. Uwagi do książki: Stanisław Waltoś, Grabież ołtarza Wita Stwosza, Wydawnictwo Wolters Kluwer SA, Warszawa 2015, ss. 407, il., mapa
Authors: Matelski Dariusz
Published: June 2017

-
Aleksander Łupienko, Kamienice czynszowe Warszawy 1864–1914, Warszawa: Instytut Historii Polskiej Akademii Nauk 2015, ss. 549 + il.
Authors: Śmiechowski Kamil
Published: June 2017

-
Jerzy Szczepański, Urzędnicy administracji państwowej Królestwa Polskiego w latach 1815–1866 (na przykładzie guberni radomskiej), Wydawnictwo Uniwersytetu Jana Kochanowskiego, Kielce 2015, ss. 144.
Authors: Tomaszewska Justyna
Published: June 2017

-
Sprawozdanie z Ogólnopolskiej konferencji naukowej zorganizowanej w 150. rocznicę powstania zabajkalskiego oraz 70. rocznicę repatriacji polskich zesłańców z głębi ZSRR pt. Losy Polaków na Wschodzie w XIX–XXI w., Łódź 5–6 grudnia 2016 r.
Authors: Biały Łukasz
Published: June 2017

-
Hiperróżnorodność lokalnie: mobilność społeczna i rozwój przedsiębiorczości na Pradze-Północ w Warszawie
Authors: Korcelli-Olejniczak Ewa , Dworzański Piotr , Piotrowski Filip
Published: June 2017

Artykuł opisuje proces gentryfikacji na Pradze-Północ, który prowadzi do hiperróżnorodności tej dzielnicy. Badania pokazują, że zróżnicowanie społeczne może mieć zarówno pozytywny, jak i negatywny wpływ na mobilność społeczną, choć żeby uruchomić jego potencjał do pozytywnych zmian, ważne jest wcześniejsze zadbanie o integrację społeczną w danym regionie. Hiperróżnorodność ma także dwojaki wpływ na przedsiębiorczość na Pradze. Z jednej strony obniża próg wejścia, ułatwiając założenie biznesu, który jest w stanie się utrzymać, ale jednocześnie znacząco utrudnia wytworzenie szerokiego grona stałej klienteli, która dawałaby przedsiębiorcom poczucie stabilności i możliwość rozwoju.
Powstawanie miast w „strefach bezmiejskich”
Authors: Szmytkie Robert , Krzysztofik Robert
Published: June 2017

Celem artykułu było wyjaśnienie zasadniczych modeli organizacji procesu umiastowienia „stref bezmiejskich” w Polsce, w kontekście oddziałujących miastotwórczych sił dośrodkowych i odśrodkowych oraz towarzyszącemu im zjawisku dyfuzji idei uprawomocnionej miejskości. Ostatecznie wskazano na dwa podstawowe modele umiastowienia w „strefach bezmiejskich” o podłożu mechanicystycznym (siły miastotwórcze) i trzy modele o zdecydowanej roli atrybutu termodynamicznego (dyfuzja).
Thumb-Rest Position and its Role in Neuromuscular Control of the Clarinet Task
Authors: Young Kathryn E , Winges Sara A
Published: June 2017

Musicians spend long hours of practice and performance to master their instrument. Clarinet players support their roughly 2-lb instrument on the right-hand thumb, which results in cumulative static loading of the arm. This posture in turn can cause discomfort and, in some cases, evolve
into debilitating overuse injuries and pain throughout the right upper limb. Altering the thumb-rest position has been proposed as a way to alleviate this discomfort, although no quantitative research has been conducted on this issue. The purpose of this study was to address the impact of
thumb-rest position on the neuromuscular control of holding the clarinet. Surface electromyographic recordings of superficial muscles that control the right thumb, wrist, and arm were taken during realistic playing tasks. Twenty clarinetists performed 10 held notes and 10 exercises on the
three different thumb-rest positions. The notes and exercises were chosen to isolate specific elements of playing. We hypothesized that a high thumb-rest position would result in a significantly different balance of muscle activity than traditional and low thumb-rest positions. The patterns
of muscle activity recorded among clarinetists were idiosyncratic, but for all players these patterns were influenced by the note(s) played and thumb-rest position, and thus the hypothesis was partially supported. Muscles that acted on the thumb and wrist were most influenced by thumb-rest
position. These results support the notion that adjustment of thumb-rest position may be a useful way to alleviate discomfort in the supporting limb but must be evaluated for each individual.
Biopsychosocial Factors Associated with Foot and Ankle Pain and Injury in Irish Dance: A Prospective Study
Authors: Cahalan Roisin , Purtill Helen , O’Sullivan Kieran
Published: June 2017

BACKGROUND: Foot and ankle pain/injury (FAPI) is the most common musculoskeletal problem suffered in Irish dancing. A prospective examination of risk factors for FAPI in this cohort has never been performed. STUDY DESIGN: Prospective study over 1-year. METHODS: 85 elite adult Irish
dancers were screened at baseline for biopsychosocial factors and followed up prospectively each month for 1 year to evaluate FAPI rates and potential risk factors. Subjects who suffered from multiple incidences of FAPI (with no pain/injury reported elsewhere in the body) or at least one moderate
episode of FAPI were allocated to the foot/ankle-injured (FAI) group (n=28, 25 F/3 M). Subjects reporting no pain/injury or only one minor FAPI were allocated to the non-injured group (n=21, 14 F/7 M). Baseline differences in variables between groups were tested with the independent samples
t-test, Mann-Whitney U-test for skewed data, and Fisher’s exact test for categorical variables. RESULTS: Baseline factors significantly associated with the FAI group included failing to always perform a warm-up (p=0.042), lower levels of energy (p=0.013), and more bothersome pain (p=0.021).
Subjects also scored worse on two dimensions of the Athletic Coping Skills Inventory: i.e., coping with adversity (p=0.035) and goal setting and mental preparation (p=0.009). CONCLUSION: Several biopsychosocial factors appear to be associated with FAPI in Irish dancers. Biopsychosocial screening
protocols and prevention strategies may best identify and support at-risk dancers.
A influência da falta de gestão adequada de custos no encerramento das empresas no Brasil
Authors: Barreto Antonio Fernandes , Antonovz Tatiane
Published: June 2017

A problemática do encerramento de jovens empresas brasileiras pode estar também relacionada à falta de conhecimento em técnicas de gestão de custos? Geralmente, grandes organizações apresentam em seus quadros funcionais profissionais especializados em gestão de diversas áreas, que dominam inclusive técnicas relacionadas à contabilidade gerencial e consequentemente em gestão de custos. Este recurso não está disponível às micro e pequenas empresas, por causa da necessidade de uma estrutura enxuta e simples. Uma pesquisa do Sebrae aponta que o terceiro motivo para o fechamento precoce de aproximadamente 25% de jovens empresas, passa por problemas relacionados à gestão empresarial, incluindo a falta de gestão adequada de custos. A pesquisa bibliográfica apontou que ferramentas consagradas como: controle de estoques; realização de orçamentos; formação de preços com um melhor controle das margens de contribuição; conhecimento do ponto de equilíbrio e melhor conhecimento nas relações de volume, custo e lucro, além da formação dos empreendedores, podem minimizar o fechamento precoce de tais instituições.
Pesquisa de clima organizacional e proposta para melhoria em uma escola técnica
Authors: Paula Filho Pedro Norberto , Kawamoto Jr. Luiz Teruo , Peterossi Helena Gemignani , Langui Celi
Published: June 2017

O presente trabalho tem por objetivo pesquisar o clima organizacional de uma escola técnica na cidade de Jundiaí, interior de São Paulo e fazer uma proposta de melhoria de gestão. Foi feita revisão bibliográfica a fim de conhecer o assunto de clima organizacional, depois foi gerado um questionário de avaliação e por fim empregada pesquisa por meio de entrevistas, questionários, avaliações e observações no local para identificação do clima organizacional da unidade escolar. Como resultados, foi detectado menos infatisfação com o trabalho entre os funcionários que o esperado e foi poposto ações que a equipe gestora possa promover e ou tomar para melhorar o clima organizacional.
Relatório de auditoria com modificação e a troca da administração em companhias listadas
Authors: Peres Lincoln Jesus , Peters Marcos Reinaldo Severino
Published: June 2017

O estudo analisou a associação entre a emissão de um relatório de auditoria com modificação e a troca de administração em companhias brasileiras listadas. Para tal, realizou-se uma pesquisa descritiva por meio de análise documental. Foram pesquisadas todas as companhias brasileiras listadas, na data-base de 31 de dezembro de 2015. Ao analisar os relatórios de auditoria emitidos, e considerando o problema de pesquisa proposto para este estudo, constatou-se que 40 demonstrações contábeis apresentam relatórios de auditoria com modificação. E, destas, observa-se que 28 companhias trocaram algum membro da administração.