bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis on Altruism-Based Coopetition Game of Oligarchic Enterprises: A Validation of Generation Companies
Authors: Jiang Lanxiang , Wang Honglei , Zhao Wei
Published: August 2020

For the long-term sustainable development, the modern enterprises should consider both competition and cooperation. In the current studies of corporate competition strategies and games, the quantification of cooperation-competition (coopetition) between enterprises is not deeply investigated. In this paper, we establish a coopetition game model of oligarchic enterprises in the industry by using the quantitative altruistic factor and nonlinear cost function, analyze the influence of altruistic factor on equilibrium variables, and then validate it in the generation side market. The following conclusions are drawn: (1) the coopetition of any form will increase the market equilibrium price and the total equilibrium profit of the industry, which induces the motivation and intention of cooperation between oligarchic enterprises. (2) The increased unilateral altruism is instable and unsustainable because it will produce an altruistic threshold that makes the total equilibrium profit of the industry increase and then decrease. The unilateral altruism of high-cost generation companies is more beneficial for increasing the total equilibrium profit of the industry, but it is realized in a difficult way. Due to a higher initial altruism level, there is lack of motivation for the increased unilateral altruism. (3) The mutually altruistic coopetition is the most effective way for improving the total equilibrium profit of the industry, but it is hard to finally achieve the complete monopoly because of cost differentiation. (4) The established game model of generation market is more universal and provides a certain quantitative interpretation for electricity crisis.
Optimal Control of Shigellosis with Cost-Effective Strategies
Authors: Edward Stephen , Shaban Nyimvua , Mureithi Eunice
Published: August 2020

In this paper, we apply optimal control theory to the model for shigellosis. It is assumed that education campaign, sanitation, and treatment are the main controls for this disease. The aim is to minimize the number of infections resulting from contact with careers, infectious population, and contaminated environments while keeping the cost of associated controls minimum. We achieve this aim through the application of Pontryagin’s Maximum Principle. Numerical simulations are carried out by using both forward and backward in time fourth-order Runge-Kutta schemes. We simulate the model under different strategies to investigate which option could yield the best results. The findings show that the strategy combining all three control efforts (treatment, sanitation, and education campaign) proves to be more beneficial in containing shigellosis than the rest. On the other hand, cost-effectiveness analysis is performed via incremental cost-effectiveness ratio (ICER). The findings from the ICER show that a strategy incorporating all three controls (treatment, sanitation, and education campaign) is the most cost-effective of all strategies considered in the study.
Fault Detection for Turbine Engine Disk Based on Adaptive Weighted One-Class Support Vector Machine
Authors: Chen Jiusheng , Xu Xingkai , Zhang Xiaoyu
Published: August 2020

Fault detection for turbine engine components is becoming increasingly important for the efficient running of commercial aircraft. Recently, the support vector machine (SVM) with kernel function is the most popular technique for monitoring nonlinear processes, which can better handle the nonlinear representation of fault detection of turbine engine disk. In this paper, an adaptive weighted one-class SVM-based fault detection method coupled with incremental and decremental strategy is proposed, which can efficiently solve the time series data stream drifting problem. To update the efficient training of the fault detection model, the incremental strategy based on the new incoming data and support vectors is proposed. The weight of the training sample is updated by the variations of the decision boundaries. Meanwhile, to increase the calculating speed of the fault detection model and reduce the redundant data, the decremental strategy based on the k-nearest neighbor (KNN) is adopted. Based on time series data stream, numerical simulations are conducted and the results validated the superiority of the proposed approach in terms of both the detection performance and robustness.
Archetypal Metaphysics and the Psyworld
Authors: Mills Jon
Published: August 2020

I address Erik Goodwyn’s insightful and nuanced critique of my work on the essence of archetypes that have direct bearing on his own investigations of archetypal origins, attractor states, the mind-body problem, and on the question of metaphysics. Goodwyn’s work is grounded in scientific naturalism while I offer an onto-phenomenological methodology that is compatible with his own positions. The questions of embodiment, ground, holism, panpsychism, and esse in anima are examined in light of offering a preliminary framework for an archetypal metaphysics where I introduce a theory of psyworld.
Jules Vuillemin et la triple controverse entre Carnap et Quine
Authors: Jacob Pierre
Published: August 2020

Jules Vuillemin était un philosophe érudit et savant ; il entretenait avec la philosophie analytique de son temps une relation étroite, mais rendue énigmatique par sa fidélité au principe de l’inséparabilité entre la philosophie et l’histoire de la philosophie hérité de l’historien de la philosophie, Martial Gueroult. La question principale que je me pose ici est de savoir quelle était l’attitude exacte de Vuillemin à l’égard de la triple controverse entre Quine et Carnap provoquée par les critiques dirigées par Quine contre la tripartition de Carnap entre les propositions analytiques (de la logique et des mathématiques), les propositions synthétiques (des sciences expérimentales) et les choix ontologiques purement pragmatiques. Tout en souscrivant à la tripartition carnapienne, Vuillemin réprouvait l’idée positiviste de l’irrésolubilité des controverses ontologiques et défendait, au nom de la liberté de la raison spéculative, l’idée de la pluralité des solutions.
Generic Structure and Rhetorical Relations of Online Book Reviews in English, Japanese and Chinese
Authors: Chik Sonya , Taboada Maite
Published: August 2020

We examine the generic structure and rhetorical relations that characterise online book reviews in English, Japanese and Chinese to describe the pragmatic features of this emerging genre in a contrastive light. The corpus we analyse contains online book reviews written by consumers for consumers. The purpose of the study is two-fold. First, we seek to identify the generic structure of online book reviews. Second, we investigate the cross-cultural variation in the rhetorical organisation of opinions and evaluations in written reviews across language communities. The reviews are analysed in terms of the generic stages of book reviews, which are determined by their overall communicative goals (Motta-Roth, 1995; Taboada, 2011). The stages are then mapped against rhetorical relations that capture the coherence and meaningful organisation of the text (Mann and Thompson, 1988). Results show that online book reviews in all three languages share a common generic structure comprising three broad stages: Metapragmatic Comment, Evaluation (Book Overall, Author, Plot, Character) and Recommendation. While Evaluation is the only obligatory stage, Metapragmatic Comment serves to prepare the reader for the Evaluation that follows. The recommendation stage is common in both English and Chinese reviews but is conspicuously absent in their Japanese counterpart. In terms of rhetorical patterns, Contrast, Concession and Antithesis relations are preferred in Metapragmatic Comment and Evaluation, while Motivation is typically present in the recommendation stage. This paper proposes a methodology for the contrastive analyses of pragmatic phenomena, illustrating this methodology through the study of an emerging online genre.
Beyond Categorization: Zhu Kerou’s Tapestry Painting Butterfly and Camellia
Authors: Tunstall Alexandra
Published: August 2020

This paper introduces the technique of kesi or tapestry weave in China through one example, Butterfly and Camellia, attributed to Zhu Kerou, a woman artist of the twelfth century. This particular weaving is attributed to a time period when tapestry weavings began to imitate the visual language of painting. The relationship between kesi and painting is explored, examining the early use of kesi as wrappers for paintings. At the same time that the basic technology of kesi weaving is discussed, the gendered nature of weaving as work in Song-dynasty China as well as the techniques of connoisseurship of kesi during the Ming and Qing dynasties are also illuminated. The motives of such connoisseurs are examined, as their writing and collection practices framed this work for all future viewers and scholars. Sources used include inscriptions on works of art, most notably one inscription mounted next to Butterfly and Camellia by the eminent Ming painter, Wen Congjian; painting and textiles catalogues; as well as early writing on kesi weave; and the weavings themselves, which tell us most clearly the artisans' intentions and concerns.
Gender, Technical Innovation, and Gu Family Embroidery in Late-Ming Shangha
Authors: Huang I-Fen
Published: August 2020

This paper takes Gu Family embroidery as a case study to discuss the contribution of technical innovation to the construction of gender in late imperial China so as to better understand Guxiu in its technical, social, and artistic contexts. Focusing on the Flowers and Fishes album (dated 1641, Shanghai Museum) by Han Ximeng, I argue that Gu family ladies, such as Han Ximeng, used embroidery as a means to display their individual creativity; and, further, by means of technical innovations, contributed not only to their family finances but also to the art and culture of late Ming Shanghai. While some of the technical innovations that the Gu family ladies achieved were driven by the desire to meet the literati aesthetic of their time, eventually, in the case of Han Ximeng, she went beyond the literati taste for ‘painting-like’ embroidery to assert the special qualities of embroidery. By affirming her own authorship, drawing attention to the feminine medium in which she worked and claiming the significance of her work with a carefully chosen subject, Han subverted the conventions of male painting in subtle ways and demonstrated her subjectivity.
Effect of Ropivacaine nanoparticles on apoptosis of cerebral vascular endothelial cells
Authors: Sun Yang , Chen Peng , Yu Miao , Xu Hui , Ma Teng , Hou Rongyao , Yu Chunlei
Published: August 2020

The objective of this study was to investigate the effect of Ropivacaine lactate glycolic acid copolymer nanoparticles on the apoptosis of vascular endothelial cells after cerebral vasospasm (CVS) in rabbits. Thirty New Zealand rabbits were randomly divided into five groups: Sham Operation,
control, blank nanoparticles, nanoparticles drug-loaded, and Ropivacaine. A model of subarachnoid hemorrhage (SAH) was established by injecting blood into the rabbits' cisterna magna twice. The mean velocity (VM) and peak systolic velocity (VP) of basilar artery were compared at one, three,
and seven days, after which the shape was observed under a light microscope. The diameter of the lumen was measured at seven days after injection. The TUNEL method was used to detect the apoptosis of endothelial cells in the basilar artery. There was no obvious edema or blood clot and the
basilar artery was clear in the Sham Operation group. In the control and blank nanoparticles groups, there was obvious swelling of brain tissue, and obvious blood clots were found at the bottom of brain, mostly around the basilar artery and Willis ring. The pool of brain bottom was dark red.
Compared with the control and blank nanoparticles group, the swelling of brain tissue in the nanoparticles and Ropivacaine groups was reduced. Administration of Ropivacaine lactate glycolic acid copolymer nanoparticles into the epidural space of the upper thoracic segment in rabbits can reduce
the apoptosis of CVS vascular endothelial cells after SAH.
Interface debonding performance of precast segmental nano-materials based concrete (PSNBC) beams
Authors: Yin Xinfeng , Zhang Ming , Wang Lei , Liu Yang
Published: August 2020

The precast segmental concrete (PSC) structures and the nano-materials based concrete beams are widely applied to civil engineering. On the other hand, it is well known that nano-materials have physical effects and can significantly improve the concrete properties of cement-based materials.
Therefore, the interface debonding performance of precast segmental nano-materials based concrete (PSNBC) beams is investigated in this study. Two concrete specimens with nano-materials and one concrete specimen without nano-materials were prepared and bonded into PSC beams with a high strength
epoxy adhesive. The smart aggregates (SAs) made of piezoceramic Lead Zirconate Titanate (PZT) and concrete are used as the intelligent transducer of monitoring test specimen. The PSC beam was loaded periodically by screw jack to simulate the random debonding damage of different degrees. The
experimental results show that the interface debonding performance of the concrete specimens with nano-materials is significantly enhanced and better than that of concrete specimens without nano-materials.
Preparation and analysis of electrochromic properties of poly(3,4 ethylene dioxythiophene)
Authors: Chang Zigong , Jiang Haiyun , Wu Ruomei , Zhang Weili , Zeng Hui , Zhang Weiran , Li Manchuan
Published: August 2020

The film of PEDOT was prepared in this study via electrochemical polymerization using EDOT as monomer in LiClO4/PC solution. The effects on the properties of the film were surveyed including the deposition voltage and deposition time. The morphology of the film was observed
by scanning electron microscopy. The electrochromic kinetics was analyzed by combination of electrochemical workstation and UV-Visible spectrophotometer such as the transmittance, transmittance contrast, coloring efficiency and the response time. The results indicated the film presents a coral
shape despites of the deposition voltage and the deposition time. In case of the application as electrochromic film, the optimal process condition is 1.3 V and 24 s. The corresponding transmittance is 82.77% in fade state. The transmittance contrast is 17.87%, and the coloring efficiency is
about 117.92 cm2/C, the response time is 0.52 s.
Identification of prognostic and immune-related lncRNAs in hepatocellular carcinoma based on the cancer genome atlas data mining
Authors: Ren Kaikai , Ma Jiakang , Zhou Bo , Lin Xiaoyan , Hou Mingyu , Zhang Ling , Yuan Ling , Ma Jun
Published: August 2020

Hepatocellular carcinoma (HCC) is a malignancy originating from hepatocytes with a high rate of distant metastasis and recurrence. HCC prognosis remains poorly understood, although its diagnosis and treatment have improved globally. Therefore, it is necessary to identify reliable predictive
and prognostic indicators of HCC. HCC gene expression profiles and corresponding clinical data were downloaded from The Cancer Genome Atlas. Seven lncRNAs (C10orf91, AC011352.3, AC015722.2, AC006372.1, PICSAR, AC110285.3, and AP001972.4) associated with immune and clinicopathological features
were identified as biomarker candidates for HCC prognosis based on single-sample gene set enrichment analysis, the ESTIMATE algorithm, and Cox PHR analyses. Altogether, the findings revealed that the seven immune-related lncRNAs may provide a reference for improving HCC prognosis.
High precision electrolytic polishing of Ni–Ti shape memory alloy for biomedical vascular stents
Authors: Han Deokhyun , Yang Hyunseok , Kong Man-Sik , Lee Changhee , Sharma Ashutosh , Ahn Byungmin
Published: August 2020

There is a continuous demand for multi-disciplinary design approaches for the development of new implant materials. A potential biomaterial that is suitable for vascular stents and catheters is Ni–Ti alloy (Nitinol), which exhibits excellent biocompatibility, superelasticity, and shape memory effects. Corrosion resistance of Ni–Ti vascular stents in body fluids is significantly dependent on its surface finishing characteristics. In the study, as-drawn Ni–Ti wires were electropolished from a methanolic sulfuric acid electrolyte. The effect of various electropolishing (EP) parameters, i.e., current density, electropolishing time, and electrode gap, on the surface properties of Ni–Ti wires were examined. The surface morphology and topography of the Ni–Ti wires were characterized via scanning electron microscopy (SEM) and atomic force microscopy (AFM). The root mean square (Ra) surface roughness of electropolished Ni–Ti wires was also measured using AFM. The results indicated that the surface finishing of Ni–Ti alloy exhibited maximum sensitivity to electropolishing current density. An optimum combination of surface morphology and roughness was obtained at a parameter set with current density of approximately 0.5 A/cm2, polishing time of 10 s, and electrode gap of 1.0 cm.
Nursing care of diabetic foot based on nanosilver antibacterial dressings
Authors: Cao Shenghua , Wu Xiaoqian , Zhao Jianling , Jia Xinhong
Published: August 2020

To investigate the control and prevention of diabetic foot infection with nano-silver antibacterial dressings and the difficulty of nursing. Sixty patients with diabetic foot, treated at our hospital between January 2017 to January 2018, were randomly assigned to intervention and control
groups (n = 30 per group). Blood glucose was strictly controlled in both groups. After debridement, the ulcerated feet of the intervention and control groups were wrapped with nanosilver antibacterial and Vaseline dressings, respectively. The degree of pain and the severity and areas
of ulcers were evaluated at the time of admission and after four weeks of treatment. The time required for ulcers to heal was assessed and the number of dressing changes were counted. The two groups were compared in terms of ease of care. Although treatment improved the Wagner grade in both
groups, the improvement was significantly better in the intervention group than in the control group (P < 0.05). Moreover, treatment reduced ulcerated areas in both groups, with significantly smaller ulcerated areas in the intervention group than in the control group (P <
0.05). The intervention group had significantly lower visual analog scores (VAS) than the control group (P < 0.05), although treatment lowered VAS in both groups. Ulcers healed significantly sooner and dressings were changed less frequently in the intervention group than in the control
group (P < 0.05). The nursing difficulty of the intervention group was significantly lower than that of the control group. Nanosilver antibacterial dressings can promote healing, reduce ulcerated areas, improve Wagner classification, and reduce the frequency of dressing changes in
patients with diabetic foot ulcers. At the same time, the use of nano-silver can reduce the difficulty of patient care.
Study on the effect of superparamagnetic γ-Fe2O3 combined with carmustine on cervical cancer
Authors: Xiao Jinghua , Li Yani , Wang Yanxia , Wang Xinru , Zhang Wanwan , Liu Kai
Published: August 2020

This study aims to investigate the killing effect of γ-Fe2O3 combined with carmustine on cervical carcinoma cells, as well as the mechanism of drug resistance of this combined treatment. RT-PCR was used to detect the expression of Multidrug Resistance
Gene (MDR-l) gene in all the samples. Results showed that the combination of γ-Fe2O3 and carmustine drugs was significantly better than the control group (P < 0.05), and the tumor showed different degrees of tolerance in combination with the drug.
The results of an in vitro drug sensitivity test were consistent with those of mRNA expression of MDR-l gene (P < 0.04). The combination of superparamagnetic γ-Fe2O3 and carmustine derivatives has a better therapeutic effect on cervical carcinoma
than either treatment alone. The drug sensitivity test and MDR-l mRNA detection in vitro can improve the accuracy and predictability of cervical carcinoma chemotherapy, providing a scientific basis for individual tumor chemotherapy.
Preparing composites of Ni–Al layered double hydroxide/graphene electrode for supercapacitors and their electrochemical properties
Authors: Zhou Yunlong , Yu Dan , Peng Junwen , Chen Xiaofang , Hu Zhibiao
Published: August 2020

The composites of Ni–Al layered double hydroxide (Ni–Al LDH)/graphene (GR) had been synthesized through the hydrothermal route in this work. The mechanism of the composites depended on XRD. Meanwhile, SEM was used to record the morphological structure of the composites.
The electrochemical properties were analyzed through the charge-discharge of constant current, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The composites of Ni–Al LDH/GR possessed a layered structure and the structure was uniformly dispersed on the graphene.
The given discharge capacity of the composites of Ni–Al LDH/GR was higher than the value of bare Ni–Al LDH, which was approximately 400 F · g–1 in the speed of 1 A g–1; Meanwhile, the capacitance retention was still more than 1 time higher
compared with the value of Ni–Al LDH for 500 cycles at 1 A g–1.
Effects of superfine grinding on the physicochemical properties of dandelion tea powders
Authors: Li Shuhuan , Chi Xiaojun , Yu Kexue , Ma Siqi , Yue Fengli , Li Yuanyuan
Published: August 2020

To investigate the effects of superfine grinding technology on dandelion tea powders (DTPs), the 80-mesh coarse and 200-mesh superfine dandelion tea powder (DTP) were prepared. A laser particle size analyzer (LPSA), scanning electron microscopy (SEM), colorimetry, and UV-vis spectrophotometry
were used to compare the differences in physicochemical properties such as particle size distribution, degree of cell breakage, fluidity and filling properties, color differences, solubility in water, total acid phenol, and flavone levels and antioxidant activities. Our results showed that
the 200-mesh superfine DTP with the smaller particle size showed better performance in the tests, and may help to establish a foundation for research and development of dandelion tea.
Effect of microstructural phases on thermo-mechanical analysis of ductile Cu–Al–Mn–Ni memory alloys for structural applications
Authors: Manzoor Tareq , Zafar Muhammad , Ali Muddassir , Saleem Mahmood , Kim Woo Young
Published: August 2020

In this present study, the particulars of an experimental investigation on the effect of nickel addition on microstructural, strain recovery and strain absorption capacity of ternary (Cu–Al–Mn) shape memory alloys has been deliberated. Six dissimilar compositions with varying
amounts of Ni in (Cu–Al–Mn) shape memory alloys have been synthesized and investigated to measure their potential for structural applications. Microstructural and detailed phase analysis has been studied. Additions of Ni have enhanced the tensile strength of these alloys. These
compositional variations have influenced shape memory and damping properties in from of dissipated strain energy as well as the super elasticity of the alloys.
Microwave absorption performance of barium hexaferrite multi-nanolayers
Authors: Handoko Erfan , Budi Setia , Sugihartono Iwan , Marpaung Mangasi Alion , Jalil Zulkarnain , Taufiq Ahmad , Alaydrus Mudrik
Published: August 2020

In this work, the microwave absorption performance of barium hexaferrite multi-nanolayers synthesized by aceramic method was investigated. The microwave absorption performances of BaFe12O19 and BaCoZnFe10O19 multi-nanolayers with thicknesses
of 25, 50, 75, 100, 200, 300, 500, and 1000 nm were evaluated using a vector network analyser (VNA) at room temperature to characterize the reflected signal (S11) and transmitted signal (S21) in the frequency range of 7–13 GHz. The microwave absorption
performance of the multilayer structure was enhanced due to the combination of nanolayers. The optimal absorption performance was achieved with a reflection loss of less than –30 dB (99.9% absorption) for a layer thicknesses of less than 500 nm.
Encapsulating doxorubicin in PEGylation metal-organic frameworks for combined radiation therapy in liver cancer treatment
Authors: Liu Dawei , Bai Bing , Sun Yanbin , Guo Youxin
Published: August 2020

It is well known that nanoscale metal-organic frameworks (NMOFs) have exhibited brilliant advantages in cancer diagnosis and treatment due to their structural diversity, high intrinsic biodegradability, and drug-loading capacities. Herein, based on our previous results, hypoxia was
suppressed by inhibiting the expression of the CA IX protein, produced from Zr-MOF nanoparticles, and enhancing radiation therapy (RT) effectiveness. We designed a nanocomposite by encapsulating doxorubicin into Zr-MOF nanoparticles. It is a highly effective drug for chemotherapy and MOF that
can absorb X-rays well, applied to enhance RT as the radiosensitizer. PEG is used for surface modification in the nanoparticles and to improve circulation time by intravenous administration. These nanoparticles could be applied for RT combing with chemotherapy in vitro and vivo,
obtaining excellent anticancer efficacy. Most importantly, Zr-MOF@Dox demonstrates high clearance from HepG2 tumor cells, reducing the circulation of toxicity in vivo. Our research exhibits a new approach to establishing Zr-MOF@Dox as a biodegradable drug-carrier system, containing
chemotherapy drugs and functional elements that totally perform the diagnosis and treatment roles of RT.
The study on knee osteoarthritis in diabetic patients based on nanometric magnetic bead method
Authors: Luo Dongbin , Hou Dabiao , Luo Simin
Published: August 2020

To study the levels of inflammatory cytokines in synovia fluid from osteoarthritis (OA) patients with/without type 2 diabetes mellitus (T2D). Out of 74 volunteers aged 20–88 years, 64 with knee OA (Kellgren-Lawrence grades over I) were recruited and divided into groups with (n =20) and without (n =44) diabetes. The nucleic acid of the patient tissue was extracted by nanometer magnetic bead method. The remaining participants were the control group (n =10). Synovia fluid, sera, and peripheral blood mononuclear cell (PBMC) samples were collected from all participants and analyzed using ELISA Kits. T2D-OA patients and OA patients had higher basal production of interleukin-1, (IL-1), interleukin-6 (IL-6), and lower-level interleukin-10 (IL-10). However, there were no differences between T2D-OA and OA patients. IL-1, IL-10, and IL-6 in peripheral blood mononuclear cells (PBMCs) after stimulation with LPS were obviously up-regulated in both patients and controls. The production of IL-1 and IL-6 in synovia from T2D-OA and OA patients increased as in the case of variations in sera and PBMCs. Both T2D-OA and OA patients had high-levels of IL-1 and IL-6 compared with controls, especially IL-6. The presence of IL-10 could not be detected in synovia from both patients and controls. Our results suggested that OA patient also had some pro-inflammatory factorsin vivo, especially in local lesion; this manifest was particularly evident in T2D-OA patients. The high-level concentration of pro-inflammatory cytokines and low-level anti-inflammatory factors could be one of the reasons why T2D-OA patients are prone to developing synovitis.
On Epicompletely Regularity
Authors: AlZahrani Samirah , Gheith Nadia
Published: August 2020

A topological space (X, τ) is said to be epicompletely regular if there is a coarser topological space (X, τ′) that is Tychonoff. In this study we investigated this natural type of complete regularity. We give some examples to explain some relationships
between epicompletely regular space and some separation axioms.
The Permeability of Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Psoralen to Human Skin in Medical Chemotherapy
Authors: Li Liangming , Yang Aihua
Published: August 2020

Objective: In order to improve the clinical efficacy and reduce the side effects, PLGA nanoparticles loaded with psoralen for external use were prepared, and the permeation, distribution and influencing factors of PLGA nanoparticles delivered via microneedles in human skin were
investigated. Methods: The psoralen nanoparticles were prepared by solvent replacement and interfacial polymer deposition. The percutaneous process of PLGA nanoparticles loaded with psoralen was observed with Franz diffusion cell and laser confocal microscope. The distribution of the
nanoparticles in each cortex was quantified by HPLC. Results: The retention of PLGA nanoparticles delivered via microneedles in the skin was significantly increased (P < 0.01), and the retention in the epidermis was greater than that in the dermis (P < 0.01); the
release rate in vitro was 75.58% after 24 hours, and less than 0.5% after 48 hours. Conclusion: PLGA nanoparticles loaded with psoralen can effectively promote the penetration and distribution of PLGA nanoparticles in human skin after being delivered to human skin through microneedles.
With the increase of depth, the amount of PLGA nanoparticles gradually decreases, and with the extension of time, the penetration promotion effect of microneedles is more obvious. PLGA nanoparticles loaded with psoralen may become one of the clinical methods to improve the photochemotherapy
of psoralen and develop a new transdermal drug delivery system to reduce its toxic and side effects.
Application of Nano Drug Carrier in the Detection of Human Hemoglobin Content
Authors: Yang Jixing
Published: August 2020

This paper studies the application of nano drug carrier in the detection of human hemoglobin content. Taking nano modified electrode as nano drug carrier, the application of nano silver particle modified silver electrode and nano poly thionine modified electrode in the detection of
human hemoglobin content is studied. Atomic force microscope, UV-Vis and FT-IR are used to characterize the nano poly(thionine), and the electrochemical properties of nano poly(thionine) modified electrode. The silver electrode decorated with nano silver particles is made. The electrochemical
behavior of hemoglobin on the modified electrode is studied. The experimental results show that a pair of redox peaks appear in the silver electrode modified by nano silver particles. With the increase of Hb concentration, the redox peak current in the cyclic voltammogram of the silver electrode
modified by nano silver particles increases correspondingly, and the hemoglobin has a good current response on the silver electrode modified by nano silver particles, which is a kind of adsorption current. The electrochemical activity of nano poly thionine shows a decreasing tendency with
pH value. After adding hemoglobin, there is a significant reduction peak near –0.4 V. With the increase of hemoglobin concentration, the reduction peak current increases accordingly. The nano poly thionine modified electrode has a catalytic effect on the reduction of hemoglobin. The
results show that the two nano drug carriers, nano poly thionine modified electrode and nano silver particle modified silver electrode, can effectively analyze and determine human hemoglobin.
Dynamic Imaging of Moving Cells Based on DNA Nanotechnology
Authors: Zhong Xin
Published: August 2020

Nanostructures based on DNA self-assembly have made great progress in recent years, and have been widely used. Therefore, the research method of dynamic imaging of moving cells based on DNA nanotechnology is proposed. The dynamic imaging process of moving cells is studied from two kinds
of DNA Nanotechnologies: DNA gene locus marker and DNA nano-fluorescence probe. Among them, crispr-cas9 system is used to mark DNA gene sites through in vitro fluorescent labeling of different sgRNAs, which can mark different gene sites in cells in multi-color and track gene sites in
living cells dynamically; based on self-assembled CdTe quantum dot @ AnnexinV-DNA nanowire fluorescent probe, based on the DNA fitness of moving cells, the system is designed to be specific to target moving cells. The specific detection of motor cells can be realized by combining the sequences.
The key point is to use the structural characteristics of the probe to realize the indication of the physiological changes of the drug receiving cells. The results show that: the polychromatic labeling of different gene sites in the same cell can be realized by using different fluorescent
labeled sgRNA. By using fluorescent labeled telomere specific sgRNA to track the movement of telomeres in living cells, it can be seen from the movement track that in living cells, Ma SAT is more flexible than that in living cells. About 84.5% of Ma SAT is not mobile, but only 12.9% for telomere.
Ma sat and the direction of telomere movement in the cell nucleus are random and in all directions. CdTe QD @ AnnexinV-DNA nanowire fluorescent probe can not only detect the moving cells, but also indicate the physiological state of normal and apoptotic cells at the same time. A large number
of S7 ends of DNA allow the probe to firmly bind to the surface of Ramos cells in the way of "twine ball." The probe can indicate the physiological state of cells, and the corresponding characteristic emission wavelength changes with the change of target cell movement state. It shows that
DNA nanotechnology can be used to analyze the dynamic imaging of moving cells in all directions and from multiple angles.
Finite Element Analysis of Multi-Position Fatigue Fracture Damage of Nuclear Pipeline Based on X-ray Scattering
Authors: Zhao Jinfang , Zhao Qun
Published: August 2020

The traditional finite element analysis method has poor performance in identification, and there are errors in the selected identification position, resulting in the fact that the accuracy of the results of the finite element analysis is not high. Therefore, based on the characteristics
of X-ray scattering, a new finite element analysis method for multi-position fatigue fracture of damage nuclear pipeline is proposed. In this method, a nuclear pipe model is constructed and the three-dimensional scattering identification density of X-ray is established. Based on the creep
curve, the material parameters of the nuclear pipeline are analyzed, and the damage index grade is divided according to the yield strength and other parameters; the equivalent stress is calculated, and the constitutive relationship between the material and the damage index is described according
to the damage value. The classical scattering formula and Stokes formula are introduced to locate the position of the X-ray cut in node by setting the spatial and temporal distribution function. The parameters of random dynamic change are calculated, and the anchor nodes and position nodes
are set to locate the scanning range of damage nuclear pipeline. Experimental results show that compared with the traditional three methods, the proposed method has higher recognition rate and more accurate finite element analysis results. It can be seen that the performance of this method
is superior.
Effect of Bruceine D on MicroRNA-155 Expression and Proliferation and Apoptosis of Human Retinoblastoma Cells
Authors: Qin Dongju , Ainiwaer Xiamuxiya , Pan Huling , Sha Qian , Zhou Xiaojuan
Published: August 2020

This study aimed to investigate the effect of bruceine D on the proliferation and apoptosis of human retinoblastoma cells and its effect on miR-155 expression. Y79 human retinoblastoma cells were cultured in vitro and randomly divided into the blank control group, DMSO (Dimethyl
Sulphoxide) group, bruceine D 10 μmol/L group, bruceine D 20 μmol/L group, and bruceine D 40 μmol/L group. MTT assay was used to detect cell hyperplasia, flow cytometry to detect the apoptosis rate, and qRT-PCR to detect the expression level of miR-155. Anti-miR-155
or miR-155 mimics were transfected into Y79 cells, and hyperplasia and apoptosis rates were detected by the above methods. Western blotting was used to detect Bcl-2, Bax, and caspase-3 expression. Bruceine D can reduce the viability of Y79 cells (P < 0.05), significantly increase
the apoptosis rate (P < 0.05), promote the expression of Bax and caspase-3 (P < 0.05), and inhibit miR-155 and Bcl-2 (P < 0.05). Compared with the anti-miR-con group, in the anti-miR-155 group, cell vigor was evidently reduced (P < 0.05), the apoptosis
rate was evidently increased (P < 0.05), and the Bcl-2 level was reduced (P < 0.05). Bax and caspase-3 levels were evidently increased (P < 0.05). Transfection with miR-155 mimics can reduce the influence of caspase D-3 in hyperplasia and apoptosis of Y79 cells.
Bruceine D may reduce the hyperplasia of human retinoblastoma cells and regulate cell apoptosis by downregulating miR-155 expression.
Regulation of Vimentin on Cell Metabolic Signaling Pathway in Muscle Injury
Authors: Wang Yi , Jia Liang
Published: August 2020

The regulation of vimentin on cellular metabolic signaling pathway in muscle injury was analyzed experimentally. Seventy experimental mice were divided into six experimental groups and one control group according to exercise training time. Muscle injury model was established by repeated
running and jumping. Vimentin expression was quantified by image analysis method, combined with pathological and ultrastructural changes of muscle tissue, and serum was detected. The regulation of vimentin metabolic signaling pathway in muscle injury cells was comprehensively analyzed by creatine
kinase, cell proliferation and vimentin expression time course in skeletal muscle of mice. The results showed that the average optical density and area of vimentin positive area of mice in each experimental group were different with different exercise degrees. During the first 6–7 weeks
of training, muscle injury had a process of gradual aggravation and alleviation, which indicated that the muscles showed good adaptability while the injury accumulated. The time course changes showed that there was some expression of vimentin in mice of different experimental groups after
exercise. The experimental results confirmed that vimentin had a regulatory role in the metabolic signaling pathway of muscle injury cells.
Synthesis of Monolayer MoS2 Films and Tuning Its Photoelectric Properties via Interface Engineering
Authors: Shen Tao , Lu Xingchen , Xu Lei , Li Zhichao , Qi Junjie
Published: August 2020

Two-dimensional (2D) materials have received considerable attention for their applications in nextgeneration optoelectronics but are limited by the synthesis of large-area films and the challenges in device optimization. In this study, a uniform MoS2 monolayer film was synthesized
by a simple chemical vapor deposition (CVD) method. Phototransistors based on the resulting MoS2 films were fabricated and their photoelectric properties were compared with that of a device with synthesized triangular MoS2 sheets. The results show that the photoresponsivity
of the film-based phototransistor is 1180 mA/W at a power density of 1 mW/cm2, far exceeding (15 times) that of the sheet-based phototransistor. Furthermore, with mild vacuum annealing, the photoresponsivity and photoresponse speed in the film-based phototransistor demonstrated
a simultaneous increase, in which the photoresponsivity reached up to 105 A/W with a decreased photoresponse/recovery time from 9 s/22 s to 5 s/8 s under illumination. This satisfactory improvement after vacuum annealing can be attributed to the removal of oxygen atoms from sulfur vacancies
and a reduced inherent van der Waals gap at the MoS2/Au interface, which facilitates the trapping of photogenerated electrons and promotes carrier separation. Our work provides a promising strategy for high-performance 2D photodetectors via rational synthesis and interface engineering.
An Effective Nanoparticle-Biomaterial in Alleviating Diabetic Cataracts
Authors: Zhang Yue , Mao Ailing , Han Longhui , Li Xiaorong , Jia Xin , Li Mingran , Li Jie
Published: August 2020

To test an effective nanoparticle-biomaterial in alleviating diabetic cataracts (DC), CCTSOS. Composed mainly of CeCl3 and TiSiO4, nanoparticle-biomaterial was invented as an new compound nano-drug for DC treatment in these researches. To prove its anti-DC
capacity, antioxidation and antiglycation in vitro and in vivo were tested and macroscopic and microscopic studies on cataract progression were carried out. hLECs and α-crystallin were used for extracorporeal test on antioxidation and antiglycation and STZ-induced
mouse model was used for anti-DC test in vivo. The results showed that CCTSOS can inhibit oxidation by reducing superoxides and peroxides. While there was an increase of SOD and PRDX1 in hLECs, there was also a decrease of MDA and an increase of GSH in vivo. CCTSOS
can alleviate glycation as shown in the decrease of CEL and the flourescence intensity of final glycated α-crystallin in vitro and in vivo. In terms of DC rescue, CCTSOS could slow down DC progress as shown in macroscopic image and grading score and presented
in LECs smear and eye slice. In conclusion, CCTSOS has a significant effect of antioxidation and antiglycation and an anti-DC effect both in vitro and in mouse model, implying that CCTSOS can be a potentially compound nano-drug for DC treatment in the future.
ICTs for Community Development: Bridging Conceptual, Theoretical, and Methodological Boundaries
Authors: Comunello Francesca , Mulargia Simone , Sarrica Mauro
Published: August 2020

The aim of this special issue is to collect and put into dialogue theoretical, methodological, critical, and applied contributions dealing with the variety of Information and Communication Technology (ICT) uses in community development. In this introduction to the special issue, we first provide the readers with a quick overview of the field, conducted by analyzing the lexicon of titles and abstracts published in the past few years in information and communication technology for development journals. We will then briefly elaborate on the concept of “users” as a pivotal dimension that can shed light on the complex interlinkages between technological artifacts and sociocultural factors involved in ICT usage. The focus on user, in fact, highlights some relevant issues concerning the relation between ICT, people and communities. Drawing on these premises, the papers collected in the special issue will then be briefly described. These contributions come from a variety of theoretical and methodological approaches, include the uptake of innovative technologies as well as top-down interventions, and focus on different regions of the world. The cross-fertilization and the range of disciplines included in this special issue result in a kaleidoscope in which different facets can be mixed, showing the individual, community, and societal aspects of community use of ICT for development.
WhatsApp and Cell Phones Among Sex Workers in India: The Impact of ICT in the Banaras Red-Light District
Authors: Minestroni Laura , Avio Edoardo Elia
Published: August 2020

The aim of this work is threefold: first, to show how, in the context of the gentrification process in the city of Banaras (now Varanasi) in India, social networking, and in particular WhatsApp video calls, make up an attempt by young sex workers in the red-light district (i.e., Shivdaspur) to overcome the spatial entrapment, physical and identity displacement issues resulting from the policies of “beautification,” and urban development of the city. For young sex workers, information and communication technology represents an opportunity toward an unprecedented self-reflexive drive which, beyond a misrecognition of their profession and the symbolic violence it represents, could reinforce their understanding of the outside world to position themselves better within their surrounding society; second, to describe the testimony of older sex workers, according to whom, the Internet “normalizes” sexual violence on a national scale where it is strictly connected to the spread of pornography on the web; finally, to analyze, through an emic approach based on informal interviews, the complexities and potentiality of the information and communication technology for development in this context to shed more light on the design of research and intervention.
Change in Total Body Water as a Metric for Predicting Need for Outpatient Intravenous Fluids in Postoperative Bariatric Patients
Authors: Matevish Lauren E. , Hawkins Alexander T. , Bethurum Alva J. , Aher Chetan V. , English Wayne J. , Williams D. Brandon , Spann Matthew D.
Published: August 2020

Background

Dehydration drives a significant proportion of readmissions following bariatric surgery. Routinely performed body composition testing and total body water (TBW) calculations may present a novel method for diagnosing dehydration for outpatient intervention. We sought to determine if a change in TBW from preoperative baseline could help identify bariatric patients requiring outpatient intravenous fluid (IVF) administration for dehydration.

Methods

The VUMC Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database was retroactively queried for all patients undergoing bariatric surgery at an accredited bariatric surgery center from January 1, 2017 to May 31, 2018. Body composition test results presurgery and postsurgery were extracted from the electronic health record. Change in TBW was compared between patients requiring outpatient IVF and those who did not use multivariable logistic regression.

Results

583 patients underwent surgery over the study period (388 laparoscopic Roux-en-Y gastric bypass, 195 sleeve). 62 (10.6%) required outpatient fluid administration for dehydration. After multivariable analysis, patients with an increased hospital length of stay at index operation were more likely to require outpatient IVF (odds ratio [OR] 1.65, 95% CI 1.22-2.2). Preexisting diabetes diagnosis was protective (OR 0.35, 95% CI 0.16-0.74). Neither 1-week nor 1-month change in TBW from preoperative baseline was significantly different between patients receiving outpatient IVF and those who did not.

Conclusion

Increased hospital length of stay predicts patients at risk of postoperative dehydration requiring IVF administration. Body composition testing and TBW were not useful in distinguishing between populations. Further research is needed to examine the efficacy of outpatient IVF in preventing hospital readmissions for dehydration.