bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling Signal Integrity in High-Frequency and Radio Frequency Circuits: A Comparison of Ohm's Law Variants
Authors: Kimuya Alex Mwololo
Published: October 2024

High-frequency circuit performance is significantly impacted by impedance variations, particularly within the low-resistance regime. Traditional Ohm's Law-based modeling approaches often fail to accurately predict circuit behavior in these conditions, leading to design inaccuracies and potential system failures. The Standard Ohm's Law-based model's prediction of infinite current as resistance approaches zero is unrealistic and hinders its application in practical scenarios. Despite recognizing these limitations, existing models have not comprehensively addressed the complex impedance behavior observed in high-frequency circuits. This paper introduces a modified version of the Ohm's Law incorporating an exponential correction term to overcome these challenges. The accuracy of the Modified Ohm's Law was evaluated through simulated experiments across a wide frequency range (1kHz to 1GHz) using various electronic components. The findings demonstrate the superior performance of the modified model in predicting currents under low-resistance and high-current conditions compared to the Standard Ohm's Law model. By providing finite and accurate current values, the proposed model effectively mitigates the unrealistic infinite current predictions of the standard approach. The enhanced predictive capabilities of the Modified Ohm's Law hold significant implications for high-frequency circuit design and analysis. Its application can improve performance and reliability in power electronics, telecommunications, and other high-frequency systems. By incorporating non-linear impedance behavior, the model offers a more accurate representation of real-world circuit conditions. Future research should focus on refining the exponential term's parameters to optimize the model's accuracy across a broader range of applications. Additionally, real-time implementation and hardware validation are essential to assess the model's practical utility in complex circuit environments.
Normalidade normativa versus normalidade factual: o embate entre Schmitt e Kelsen
Authors: Sgarbi Adrian
Published: October 2024

Em 'Problemas Fundamentais do Direito Público', publicada em 1911, Hans Kelsen explora a estrutura normativa e a 'vontade do Estado'. Ele aprofunda a relação entre Direito e Estado, abordando a 'obrigação jurídica estatal' e o papel dos órgãos estatais, desenvolvendo essas ideias ao longo das décadas de 1920 e 1930, um período crítico para a evolução da sua teoria estatal. Nesse tempo, Kelsen refinou suas teorias em obras como 'O Conceito Sociológico e o Conceito Jurídico do Estado' (1922), 'Teoria Geral do Estado' (1925), e 'Teoria Pura do Direito' (1934). Seu esforço em distanciar o Direito das influências sociológicas e focar na normatividade é evidente, criticando as 'teorias de potente influxo' por não se centrarem nesse aspecto normativo. Ele continuou a desenvolver esses pontos até suas obras mais maduras, como 'Teoria Geral do Direito e do Estado' (1945) e a edição de 1960 de 'Teoria Pura do Direito'. Este ensaio visa elucidar aspectos específicos do pensamento kelseniano relacionados ao enquadramento normativo do Estado e agrupar seus empreendimentos teóricos, permitindo que o leitor reconheça as soluções propostas por Kelsen. A análise discute a tendência humana de personificar entidades e a delimitação jurídica do conceito de pessoa, culminando na exposição dos 'elementos constitutivos do Estado', oferecendo uma compreensão abrangente das críticas e contribuições de Kelsen à teoria do Estado e do Direito.
Association between Helicobacter pylori infection and gastric adenocarcinoma: a retrospective and comparative analysis
Authors: Rodrigues Beatriz Joana Barreto , Brisotti João Luiz , Gomes Camila Moreira , Costa Ricardo Filipe Alves da
Published: October 2024

The Helicobacter pylori infection increases the risk of development gastric neoplasia. This is the most important risk factor for causing intestinal adenocarcinoma, which is the most prevalent gastric cancer, and is also strongly associated with mucosa-associated lymphoid tissue lymphoma - MALT. A retrospective and comparative analysis was carried out at Hospital de Amor de Barretos, a reference oncology service, in the years 2017 and 2021, in order to determine whether there is an association between the existence of the infection and gastric adenocarcinoma, and whether there was any change over 05 years. In total, 369 medical records of patients diagnosed with gastric cancer were analyzed, 218 and 151, respectively. In 2017, 45.1% of patients were investigated for Helicobacter pylori and 54% in 2021 (p=0.104). Infection was detected in 42.3 and 33.3% (p=0.232) respectively, and eradication therapy in 19.5 and 24%. Although the present study was carried out in a referral oncology hospital, it was not possible to objectively determine the relationship between Helicobacter pylori infection and the development of gastric adenocarcinoma.
Custos na administração pública - uma nova agenda de pesquisa
Authors: Giacheti Guilherme Godoy Silva , Vieira Saulo Fabiano Amâncio
Published: October 2024

Este artigo aborda a análise de custos na administração pública, com foco na produção científica sobre o tema na plataforma SPELL. A pesquisa bibliográfica visa identificar padrões, tendências e lacunas neste tema relevante pela necessidade crescente de eficiência e transparência na gestão dos recursos governamentais. A motivação para o estudo está no impacto da gestão de custos na formulação de políticas públicas e na eficiência dos serviços públicos. A pesquisa selecionou 31 artigos da plataforma SPELL. A amostra incluiu artigos predominantemente publicados em periódicos nacionais, destacando a predominância de autores com formação em Ciências Contábeis e Administração, e um vínculo institucional majoritariamente público. O estudo revelou que a maioria dos trabalhos tem natureza empírica e abordagem quantitativa, com destaque para o uso de estudos de caso e análise documental. Entre os resultados, observou-se um crescimento modesto nas publicações, além da forte presença de referências legais, demonstrando a relevância do arcabouço legal. A análise também sugere que não há um padrão estabelecido na gestão de custos entre os municípios e estados brasileiros, o que dificulta comparações e a implementação de boas práticas. Conclui-se que o estudo reforça a importância de uma agenda futura de pesquisa que explore novas abordagens metodológicas e interdisciplinares. A recomendação é expandir o uso de métodos como a Análise Envoltória de Dados (DEA) e promover pesquisas comparativas entre regiões e setores. A integração entre acadêmicos e gestores públicos também é essencial para aprimorar a eficiência na gestão de recursos e incentivar práticas mais eficazes e transparentes.
Análise espacial da incidência da Tuberculose e sua associação com os indicadores socioeconômicos no Amazonas
Authors: Cunha Linda Karolinne Rodrigues Almeida , Santos Enock Barroso dos , Lopes Neto David
Published: October 2024

Objetivo: Identificar a relação espacial entre a incidência da TB e as condições socioeconômicas para o de 2010 a 2018 no estado do Amazonas. Método: Trata-se de um estudo ecológico de abordagem quantitativa, realizado no estado do Amazonas, por meio de levantamento de dados de fontes secundárias do SINAN. Foram aplicados os testes Moran global para análise da autocorrelação espacial, e a análise bivariada LISA para avaliação da correlação espacial entre a taxa de incidência por tuberculose e os indicadores socioeconômicos. Resultados: Foram registrados 24.523 casos novos de tuberculose no estado do Amazonas, destes a maioria foram de indivíduos do sexo masculino, com faixa etária entre 20-39 anos, tendo por escolaridade ensino fundamental incompleto e da raça/cor parda. Através da análise bivariada (Moran global) foi observado correlação negativa dos indicadores socioeconômicos com as taxas de incidências suavizadas da tuberculose, na aplicação do LISA foram identificadas áreas estatisticamente significativas. Conclusão: Na associação espacial local os indicadores: taxa de analfabetismo, índice de Gini, percentual de moradores por domicilio maior que três, proporção de pobreza e percentual de domicílios com saneamento inadequado foram estatisticamente significativos
La Cybersecurity negli enti locali
Authors: Bruschi Danilo , Ferrara Alfio , De Corato Marzio
Published: October 2024

La cybersicurezza dei comuni lombardi è incoraggiante ma non priva di rischi. La consapevolezza della sua importanza è diffusa, ma occorre supportare gli enti locali affinché compiano un necessario salto qualitativo, anche nei confronti degli attacchi più comuni che colpiscono e mietono vittime tanto nel settore pubblico quanto in quello privato. È questo il frutto della ricerca coordinata da Danilo Bruschi, direttore del Dipartimento di Informatica dell’Università degli Studi di Milano, all’interno delle attività del centro MEIEC in collaborazione con AnciLab.
 
Le immagini del libro ad alta risoluzione sono disponibili anche su Dataverse.
Morphological analysis of selected clones of Populus ciliata × Populus maximowiczii hybrid
Authors: Mohanty T. , Khurana D.
Published: October 2024

While studying the morphology of Populus ciliata × P. maximowiczii hybrid it was found that the growth potential was maximum in clone CM2 4-15/91 with height and diameter of 2.11 m and 1.70 cm respectively. Average leaf blade length was 1.9 times compared to average maximum leaf width and average nerve length was 5 times to average petiole length in the clones studied. Average stomatal density was found around 240 stomata mm-2 with average stomatal length was 1.6 times than the average stomatal width. The stomata was found to be elliptic shaped and paracytic type with elaborate stranded patterns found emanating from stomata. The details of qualitative morphological variability found in the clones are presented in detail in this paper.
MINERALOGY AND GEOCHEMISTRY ASSESSMENT OF THE CRETACEOUS SEDIMENTS IN KANADI-1 WELLS, BORNU BASIN FORMATION, NORTH-EASTERN NIGERIA
Authors: Mafimisebi Peter , Martins Grace , America Alex , Ehimentan Bidemi
Published: October 2024

Mineralogical and Geochemical prospect were used to evaluate the Cretaceous and Tertiary sediments in the Bornu Basin of northeastern Nigeria, particularly those found in Kanadi-1 Wells, seeks to gain insight into their origins and how they were deposited. The Bima Sandstone Formation, the sandy-shale Gongila Formation, and the clayeyshaley Fika Formation, are mainly composed of around 35-58% quartz and up to 50% kaolinitic clay. Notably, the quantity of quartz decreases steadily across the stratigraphic sequence. The base of the Bima Sandstone Formation is characterized by its abundance of arkosic characteristics, consisting of 25% albite feldspars. The sandy layers in the Bornu Basin formation (Bima and Fika) are particularly distinguished by containing 15-25% barite. The SiO2/Al2O3 ratios, ranging from 5 to 6, indicate that the sediments are mostly sandy, while the (NaO +K2O)/(MgO+CaO) ratios of 1 to 2 in the Bima and Gongila Formations show their calcareous nature. Significant increase of barite in both Bima, Gongila, and lower parts of the Fika Formations shows there is presence of 2-3% SO3. These sediments are believed to have originated in environments resembling shallow, tropical conditions. The mineralogical and geochemical features of Cretaceous and Tertiary sediments in the Bornu Basin suggest promising opportunities for exploration. Further research in hydrocarbon, mineral resources, and paleoenvironmental reconstruction can maximize their potential.
“Microanalysis oriented bactericidal effect of the Suvarna Bhasma containing incinerated gold nanoparticles against the Pseudomonas Aeruginosa”
Authors: Shankari Sahana , Singh Brij , Nath Gopal , Srivastava Anchal
Published: October 2024

The antibacterial activity of synthetically prepared gold nanoparticles is well-known. In this unique study, the Suvarna bhasma containing the incinerated gold particles was tested for its bactericidal activity against Pseudomonas aeruginosa. The microanalysis of Suvarna bhasma was done through scanning electron microscopy, which revealed that, the gold particles' size ranged from 28 nm to 8.1 µm, forming particle agglomerates of a spherical shape with rough surfaces and heterogeneous distribution. The transition electron microscopy revealed that the particle size ranged between 2.2 to 18.96nm after the sonication of Suvarna bhasma. The energy dispersed X-ray analysis of the Suvarna bhasma sample revealed that it contained 86.3% gold, 3.1% oxygen, and 10.5% carbon. The X-ray diffraction findings of Suvarna bhasma showed four intense peaks of pure gold nanoparticles at (1 1 1), (2 0 0), (2 2 0), and (3 1 1) depicting that gold existed in a face-centered cubic crystalline lattice phase with an average particle size of 27.58 nm.
The Minimum Inhibitory Concentration of Suvarna bhasma, through the broth microdilution method, was seen to be 312µg / mL against Pseudomonas aeruginosa ATCC 27853 grown in brain-heart infusion. In contrast, the Minimum Bactericidal Concentration was 1250 µg / mL. This result was substantiated by scanning electron microscopy analysis of the P. aeruginosa (10 x 6 colony forming units) treated with 1000 µg/mL of Suvarna bhasma, showing cellular structural damage as membrane rupture, cell shrinking and death. Hence, Suvarna bhasma may be one of the futuristic antipseudomonal agents.
The effectiveness of Zaontz urethral stent in hypospadias treatment in terms of children comfort according to the Parents' Postoperative Pain Measurement (PPPM) scale: A retrospective study
Authors: Yalcin Kenan , k Vildan
Published: October 2024

Aim: Advances in the techniques and materials used in hypospadias surgery are aimed at improving cosmetic and functional results. In our study, we aimed to compare the impact of using Zaontz urethral stent (ZUS) on patient comfort in children undergoing hypospadias surgery, as opposed to feeding tubes.
Materials and Methods: A total of 178 patients who underwent distal hypospadias surgery were included in the study. Snodgrass technique was performed routinely in all cases. In all cases, 6 Fr, 8 Fr and 10 Fr urethral stents were used depending on the surgical situation. Patients were divided into two groups according to the catheterization method. While in Group 1, catheterization was performed with a feeding tube, ZUS was used in Group 2. Demographic data of the patients were analyzed. In the postoperative period, the groups were compared in terms of patient comfort according to the Parents' Postoperative Pain Measurement (PPPM) scale. This scale was evaluated three times a day during the hospitilation period. A score of at least 6 out of 15 was considered clinically significant pain.
Results: Age, catheterization size, operation and hospitalization time were similar between the groups (p>0.05). PPPM score in Group 2 was observed as 3.25, significantly lower than Group 1 (p<0.001).
Conclusion: As a result of our study, it was observed that ZUS would positively contribute to postoperative patient comfort in hypospadias repair.
INTRODUCING RETROGRADE AUTOLOGOUS PRIMING FOR BLOODLESS OPEN-HEART SURGERY IN A NEW CARDIAC CENTRE: INITIAL OUTCOMES
Authors: LU Murat , Z Munacettin , SAMURCU brahim
Published: October 2024

ABSTRACT
Objective: The use of priming fluid in the cardiopulmonary bypass causes hemodilution and increases the need for blood transfusions. Retrograde autologous priming is known to be beneficial in reducing blood transfusion and hemodilution. In this article, 38 cases were retrospectively reviewed to demonstrate the feasibility of routine retrograde autologous priming in a newly established cardiac surgery center.
Materials and Methods: A total of 38 patients underwent open-heart surgery between January 2024 and July 2024. All patients were operated using a cardiopulmonary bypass machine primed with retrograde autologous blood. Perfusion and anesthesia techniques were the same for all patients. Hematocrit levels in the preoperative period, during weaning, on the first postoperative day, third day, discharge day, and 10th postoperative day were retrospectively analyzed. Postoperative hemodynamic parameters, pressor requirements, and fluid requirements were recorded. Length of stay in the hospital and intensive care unit, as well as blood requirements, were retrospectively analyzed.
Results: No major bleeding and mortality was observed. Hematocrit levels during cardiopulmonary bypass ranged from 28% to 31%. The transfusion rate for per patient was 0.13 units.
Conclusion: It was proven that the routine use of retrograde autologous priming, even in a newly established heart surgery institution, is safe, repeatable, and effective in decreasing hemodilution and red cell transfusion rates in cardiac operations.
Evaluation of potential drug-drug interactions of metformin using different software programs: A single-center retrospective study
Authors: Kizilay Harun , Ceylan Cengizhan , Rama Seyma , Kurtoglu Zeynep
Published: October 2024

Aim: Given that metformin is often recommended for the management of type 2 diabetes mellitus, it is clinically significant to consider the potential interactions between metformin and other medications. In this study, we aimed to identify potential drug-drug interactions associated with metformin by retrospectively analyzing the prescriptions of patients taking metformin.
Materials and Methods: Metformin-containing prescription data of five independent community pharmacies in Konya province for the year 2023 were analyzed retrospectively. Medscape®, Drugs® and LexiComp® software programs were used to detect potential drug-drug interactions. As a result of power analysis with the G Power program, 400 patients were included in the study with an effect size of 0.25, type 1 error of 0.05 and confidence interval of 0.95. Kendall's W analysis was performed to determine the concordance between the software programs.
Results: Kendall's W value indicating the agreement between Medscape®, Drugs® and LexiComp® software programs was calculated as 0.061. In terms of potential drug-drug interactions of metformin, the agreement between the software programs was observed to be slight. The highest agreement between the progrmas was observed between Medscape® and LexiComp® (Kappa coefficient=0.44).
Conclusion: Since potential drug-drug interactions are common in prescriptions for patients taking metformin, these interactions should be carefully monitored. Clinicians should use multiple interaction programs to identify potential drug-drug interactions of metformin.
Evaluation of white matter properties in sinus vein thrombosis with diffusion tensor imaging
Authors: Balsak Serdar , Kula Asl
Published: October 2024

Objective: Brain MRI findings in sinus vein thrombosis have been well described in many studies. However, to our knowledge, there is no diffusion tensor imaging (DTI) study in these cases in the literature. The main purpose of this article is to examine white matter integrity in sinus vein thrombosis and to better understand the possible underlying white matter damage.
Materials and Methods: Our retrospective study is a neuroimaging study including 1.5 T MRI and brain diffusion tensor imaging (DTI) to evaluate the white matter integrity of patients with sinus vein thrombosis and healthy controls. White matter DTI abnormalities were evaluated according to ROI. DTI findings of cases and healthy controls were compared.
Results: In cases with sinus vein thrombosis, higher apparent diffusion coefficiency (ADC) values were detected in cingulum, middle cerebellar peduncle, optic radiatio compared to healthy controls. Decreased fractional anisotrophy (FA) values were detected in cingulum, corona radiata, corpus callosum splenium, anterior limb of internal capsule, posterior limb of internal capsule, optic radiatio and corticospinal tract. High radial diffusivity (RD) values were detected in cingulum, corona radiata, superior longitudinal fasciculus, anterior limb of internal capsule, posterior limb of internal capsule, middle cerebellar peduncle, optic radiatio and corticospinal tract. Low axial diffusivity (AD) values were detected in cingulum, posterior limb of internal capsule and corticospinal tract.
Conclusion: Our findings may suggest intercellular edema and axon and myelin damage in white matter tracts in sinus thrombosis. DTI findings may be useful in quantitatively monitoring the response to treatment.
Investigation of the Relationship Between Cobb Angle and Inflammatory Markers in Patients with Adolescent Idiopathic Scoliosis
Authors: uslu emine
Published: October 2024

Introduction: The role of inflammation and immune system pathologies in individuals with Adolescent Idiopathic Scoliosis (AIS) has recently been the focus of research. It has been reported that neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR) and monocyte/lymphocyte (MLR) ratios may be markers of inflammation severity. In addition, systemic immune inflammation index (SII), including peripheral neutrophils, lymphocytes, monocytes and platelets, systemic inflammatory response index (SIRI) and systemic inflammation total index (AISI) are also known as inflammation marker indexes. This study aimed to investigate the relationship between NLR, PLR, MLR, SII, SIRI, AISI and Cobb angle in individuals with AIS.
Materials and Methods: Pediatric patients aged 10-18 years who were requested to have scoliosis radiography with a preliminary diagnosis of AIS were retrospectively screened. Cobb angles, neutrophil, lymphocyte, platelet, monocyte, neutrophil percentage, white blood cell (WBC), hemoglobin values ​​were recorded. NLR, PLR, MLR, SII, SIRI, AISI values ​​were calculated. Patients were divided into 4 groups according to their Cobb angles. It was examined whether there was a difference between the groups in terms of neutrophil, lymphocyte, platelet, monocyte, neutrophil percentage, WBC, Hemoglobin, NLR, PLR, MLR, SII, SIRI, AISI values. It was examined whether there was a correlation between the Cobb angle and NLR, PLR, MLR, SII, SIRI, AISI in patients diagnosed with scoliosis and having a Cobb angle greater than 10 degrees.
Results: A significant difference was observed between Groups 2 and 4 in NLR. While a positive correlation was observed between Groups 2, 3, and 4 patients with a Cobb angle greater than 0 and NLR; no correlation was observed between PLR, MLR, SII, SIRI, AISI.
Conclusion: NLR, which is known to be associated with the severity of inflammation, is a marker that correlates with the scoliosis angle in patients with AIS. Larger-scale studies are needed to elucidate the relationship between AIS and NLR.
THE IMPACT OF AGOMELATINE AND MELATONIN ON HUMAN COLORECTAL CANCER: AN IN VITRO INVESTIGATION
Authors: Serhatlioglu Ihsan
Published: October 2024

Aim: Colorectal cancer (CRC) affects approximately one million people worldwide each year, with 500,000 deaths annually. In our country, CRC ranks as the third most common cancer in women and the fourth in men. Melatonin, a hormone with well-established antioxidant and anti-cancer properties, is produced by the pineal gland. Agomelatine, a recent addition to our antidepressant therapies, also acts on melatonin receptors and may offer therapeutic benefits in cancer treatment. This study investigates the effects of melatonin and agomelatine on the viability of human colorectal cancer cell lines (HCT-116 and Caco-2).
Materials and Methods: We treated HCT-116 and Caco-2 cell lines with melatonin and Agomelatine dissolved in 96% ethanol at concentrations of 0.1, 1, 5, and 10 mM for 24 hours. Cell viability was measured using 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolyum bromide (MTT) assay. Statistical analyses were performed using IBM SPSS Statistics 24.0, applying Bonferroni correction and the Mann-Whitney U-test, with significance set at p<0.05. The half-maximal inhibitory concentration (LogIC50) was calculated from the MTT assay results.
Results: All tested concentrations of melatonin and agomelatine significantly reduced cell viability in both HCT-116 and Caco-2 cell lines (p<0.05).
Conclusion: The study demonstrates that both agomelatine and melatonin possess significant cytotoxic and anti-tumor effects against human colorectal cancer cells.
Helicobacter Pylori Prevalence in Colorectal Polyps: Increased Risk of Neoplastic Transformation
Authors: Ciftel Sedat
Published: October 2024

Aim: The aim of this study was to investigate the prevalence of Helicobacter pylori (H. Pylori) in colorectal polyps and whether this infection differs according to neoplastic and dysplastic polyp types.
Materials and Methods: A total of 593 patients (mean age 59.5±12.0), 279 females and 314 males, who underwent colonoscopy and endoscopy at Erzurum Training and Research Hospital were included in the study. The patients were grouped into two groups with endoscopic findings. These groups are patients with colorectal polyps (n=330) and those with normal colonoscopy results (n=263). The presence of H. Pylori infection was diagnosed with endoscopic biopsy. Hematological parameters were analyzed.
Results: H. Pylori positivity was detected at a rate of 59.1% in patients with colorectal polyps, while this rate was found to be 21.3% in the normal colonoscopy group (p<0.001). In patients with H. Pylori-positive colorectal polyps, 92.3% of the polyps were neoplastic polyps, and 7.7% were non-neoplastic polyps. The frequency of dysplasia was 66.2% in the H. Pylori positive group and 24.4% in the H. Pylori negative group. H. Pylori positivity increases the risk of neoplastic polyps by 3.2 times (OR=3.2, CI=1.6-6.4, p<0.001) and dysplasia by six times (OR=6.0, CI=3.6-9.8, p<0.001).
Conclusion: Our study demonstrated that H. Pylori infection is strongly associated with colorectal polyps, especially neoplastic and dysplastic polyps. The findings suggest that H. Pylori infection might be a possible risk factor for the colorectal cancer development and that H. Pylori eradication can be considered in cancer prevention strategies.
Investigation of Melatonin Receptors Gene Expression Levels in the Hippocampus and Hypothalamus in Rats with an Experimental Morphine Dependence Model
Authors: Cimen Yasin , Ozdengul Faik , gunes canan , Kurar Ercan , Gormus Zulfikare , Sak Kaniye , kutlu selim
Published: October 2024

Objective: Morphine is one of the important opioids used in chronic and acute pain management. However, it has many side effects, including the development of addiction, which seriously limits its use. Melatonin shows its physiological effects through melatonin receptor 1 (MT1), melatonin receptor 2 (MT2) and heterodimer receptors (MT1/MT2). No study has examined the presence of MT1/MT2 mRNA in the hypothalamus and hippocampus and its relationship with the addiction process. The aim of this study was to investigate the gene expression levels of MT1, MT2 and MT1/MT2 in rat hippocampus and hypothalamus during morphine addiction and morphine withdrawal.
Materials and Methods: A total of 36 male Wistar rats were divided into 3 groups (n=12). Control (C) group received saline subcutaneously for 6 days. Morphine (M) and morphine+naloxone (M+N) groups received 10 mg/kg/day morphine subcutaneously for 6 days. On the seventh day, saline was injected intraperitoneally into C and M groups and 1 mg/kg naloxone was injected intraperitoneally into M+N group. 30 minutes later, hippocampus and hypothalamus tissues of rats were dissected. Melatonin receptor gene expression level was analysed by quantitative qPCR.
Results: Both MT1 and MT1/MT2 gene expression levels in the hypothalamus were in the M+N group than in the C group (p<0.05). There was no difference between the expression levels of MT2 receptors in the hypothalamus (p>0.05). There was no difference in MT1, MT2 and MT1/MT2 gene expression in the hippocampus (p>0.05).
Conclusion: This is the first study to show the presence of MT1/MT2 in the hypothalamus and hippocampus, and it is possible that MT1 and MT1/MT2 receptors, especially in the hypothalamus, play a role in the addiction process.
Comparative Study Between Synergetic Control and Sliding Mode Control using MPPT Techniques
Authors: Bouguerra Khoukha , Latreche Samia , Khemliche Hamza , Khemliche Mabrouk
Published: October 2024

Researchers are focusing on extracting maximum energy from photovoltaic cells due to non-linear characteristics like solar radiation, temperature, carrier, misdirection, and internal current. Advanced DC-Link controllers and current controllers, DC/DC boost converter, MPPT controller, DC-AC inverter phase reactive power compensation operation, synchronization and current grid supply are required. Synergetic control SC is introduced as a new tool in PV control, and we compared it with sliding mode control SMC stands out as a powerful and effective tool. We have implemented techniques such as sliding mode-based MPPT controller and synergetic control SC to allow us to conduct a general study and a comprehensive, taking into account factors such as efficiency, complexity and response time. SC algorithms show efficiency and superiority over MPPT-SMC algorithms in terms of stability, efficiency, speed of response, and maximum power point output without chattering. A PV Grid-Connected System model was created at Simulink to confirm the effectiveness of the proposed global synergistic control mechanism.
Comparative study of different types of DC/DC converters for PV systems using RBF neural network-based MPPT algorithm
Authors: Zaidi Sarra , Meliani Bouziane , Bouddou Riyadh , Mohammed Belhadj Souheyb , Bouchikhi Nasreddine
Published: October 2024

In this article, a detailed comparison of various DC/DC converter topologies for photovoltaic (PV) systems is presented, focusing on conventional step-up converters and advanced quadratic step-up converters. The research is part of an enhanced maximum power point tracking (MPPT) strategy, using a radial basis function (RBF) neural network. The RBF-based MPPT algorithm efficiently tracks the optimal duty cycle by accurately identifying the maximum power point (MPP) of the PV system under various irradiance and thermal conditions, ensuring maximum energy extraction. The system is modeled using MATLAB/Simulink. The simulations include a complete PV configuration comprising solar panels, a resistive load, and an MPPT controller regulated by Pulse Width Modulation (PWM) signals. Performance indicators such as energy conversion efficiency, response time, and system stability are evaluated for both inverter topologies. The results show the superiority of the quadratic boost converter in terms of higher voltage gains and improved efficiency under certain operating conditions while exposing its limitations in terms of complexity and cost. This analysis offers valuable insights for optimizing the choice of converters.
Enhancing Photovoltaic Power Forecasting through Hybrid Deep Learning Models: A CNN-RNN Approach for Grid Stability and Renewable Energy Optimization
Authors: Bouziane Abdelghani , Bouziane Mohammed , Naima Khatir
Published: October 2024

This paper addresses the critical need for accurate photovoltaic (PV) power generation predictions to ensure efficient grid integration and management, especially considering the variability and intermittency of solar power. By exploring advanced deep learning techniques, including Convolutional Neural Networks (CNN), Recurrent Neural Networks (RNN), and a hybrid CNN-RNN model, the study aims to enhance the accuracy and reliability of solar power forecasts. The CNN model achieved an accuracy of 0.84, while the RNN reached 0.94, with the highest accuracy of 0.99 attained by the hybrid CNN-RNN model. These models provide vital tools for mitigating fluctuations in solar power output, improving grid stability, and optimizing energy distribution. The study contributes to the advancement of renewable energy forecasting, helping to ensure a more sustainable and reliable energy future, while also supporting efforts to reduce CO2 emissions and combat climate change.
Improved Sliding Mode Control of a Wind Turbine System Based on a Developed Permanent Magnet Synchronous Generator
Authors: Yachir Amina , Belabbes Abdallah , Merabet Boulouiha Houari , Bouddou Riyadh , Bouzid Allal El Moubarek , Bouchikhi Nasreddine , Adiche Sarra
Published: October 2024

Wind energy conversion systems (WECS) are emerging as among the most reliable alternative energy sources, requiring innovative control strategies to improve performance and reduce operating costs. The objective of this paper is the implementation of sliding mode control (SMC) for a permanent magnet synchronous generator (PMSG) to optimize the dynamical response and wind turbine system (WTS) stability. The control architecture comprises the PMSG, an AC-DC power converter, and a DC bus link, with a particular focus on extracting the optimum wind turbine power during variable wind speeds. A complete system model was developed and tested in MATLAB for a PMSG of 2 MW subjected to uncertain fluctuations in wind speed. The simulation results confirm that the SMC technique significantly improves speed-tracking accuracy, minimizes current ripple, and improves overall system stability. In addition, the proposed method ensures robust performance under non-linear and uncertain conditions, making it a viable solution for large-scale wind applications. These results highlight the potential of SMC to enhance the accuracy and efficiency of the WECS.
ABSTRACT BOOK: I Conference for The Amazon We Want
Authors: Nobre Carlos , Peña-Claros Marielos , Dias Braulio , Viscarra Riveros Federico Ernesto , Leite Lucas Isabella , Barredo Lauren , Nascimento Nathalia , Oz Eliran , Ribeiro Cristina , Williams Catherine , Siquiera Vinícius Leonardo , Sperandeo Gabriel , Topf Julie , Arnal Gabriela , Potter Lila , Macaluso Alyssa
Published: October 2024

The Abstract Book of the I Conference for the Amazon We Want presents 43 abstracts of scientific projects produced by students, professors, researchers, and Indigenous leaders dedicated to advancing scientific knowledge as a foundation for actions aimed at the conservation and pursuit of sustainable socio-economic and ecological solutions for the Amazon region.
The Impact of Cooperative Learning Activities using the Team-Assisted Individualization (TAI) Technique Combined with Activity-Based Learning on Problem-Solving Abilities and Mathematical Connections Abilities in the Subject of Congruence
Authors: Mingolo Narintra
Published: October 2024

This research is a quasi-experimental study with the following objectives: 1) To examine the effectiveness of cooperative learning activities using the TAI technique combined with activity-based learning on the topic of congruence for students at Roi Et Rajabhat University, aiming to achieve the 75/75 efficiency criterion. 2) To compare mathematical problem-solving abilities before and after implementing the learning activities. 3) To compare mathematical connection abilities before and after the learning activities. The sample group consisted of 24 students enrolled in the Number Theory course during the first semester of the academic year 2024, selected through cluster sampling. The research instruments included: 1) Four lesson plans for cooperative learning activities using the TAI technique combined with activity-based learning, 2) A subjective test measuring mathematical problem-solving abilities consisting of five items, and 3) A subjective test measuring mathematical connection abilities consisting of five items. The statistical methods used were mean, percentage, standard deviation, and the Wilcoxon Signed Rank Test. The research findings revealed that: 1) The cooperative learning activities using the TAI technique combined with activity-based learning achieved an efficiency of 80.83/78.85, which was higher than the specified criterion. 2) The students’ mathematical problem-solving abilities on the topic of congruence were significantly higher after the learning activities at the .05 level of significance. 3) The students’ mathematical connection abilities on the topic of congruence were significantly higher after the learning activities at the .05 level of significance.
Sustainability Practices and the Corporate Cost of Equity in Emerging and Developed Markets
Authors: Balassiano Rafael Salim , Jucá Michele Nascimento
Published: October 2024

Sustainability practices have been attracting growing interest from firms and society in general. Their adoption generates the expectation of improving firms’ financial performance. However, empirical studies did not reach a consensus on the effects of these practices. This study investigates whether adopting sustainable practices negatively impacts firms’ cost of equity. In addition, it analyzes the moderating effect of the country’s development level on this relationship. We conducted a multilevel regression analysis using data from the Bloomberg, Capital IQ Pro, and World Bank databases covering the period from 2010 to 2022. The sample included 5,638 non-financial firms from developed countries (the United States, Japan, Germany, the United Kingdom, and France) and emerging countries (China, Indonesia, India, South Africa, and Brazil), considering three levels: time, firm, and country. The results revealed a negative relationship between sustainable practices and firms’ cost of equity. Furthermore, firms in developed countries that adopt sustainable practices tend to have a lower cost of equity than those in emerging countries. These findings contribute to the ongoing debate in academic literature and help to reduce investors’ uncertainty when allocating capital to sustainable firms. Finally, the results support regulators in confirming the effectiveness of sustainability-oriented policies.
Multidisciplinaire opvolging van androgeen deprivatie therapie bij mannen met een parafiele stoornis
Authors: Verschueren Sophie , Jeandarme Inge , Gijs Luk , Bokern Hein , Marcq Philippe , T’Sjoen Guy , Van de Putte Dirk , Van Haecke Bieke , Vanderschueren Dirk
Published: October 2024

Multidisciplinary follow-up of androgen deprivation therapy in men with a paraphilic disorder

Background. Androgen deprivation therapy (ADT) is frequently used in the treatment of men with a paraphilic disorder. Due to ethical reluctance, there is a lack of randomized controlled trials in this target group to make evidence-based statements about somatic and psychiatric follow-up of ADT in Flanders and the Netherlands.

Aim. Creating recommendations on the follow-up of ADT in men with a paraphilic disorder based on the experience of medical experts.

Method. Using a modified Delphi method, 22 experts were questioned in three rounds about different aspects of the somatic and psychiatric follow-up of ADT.

Results. Based on the degree of consensus between the experts recommendations were made concerning the somatic and psychiatric follow-up of ADT. The follow-up of ADT must be carried out by a multidisciplinary team, led by a forensic psychiatrist. High doses of cyproterone acetate (CPA) should be avoided, as a switch to a gonadotropin releasing hormone-agonist (GnRH agonist) is preferred. The expert opinion is very much in line with the influential WFSBP guideline, beyond some identified differences that rely on conflicting findings in existing research.

Conclusion. The essence of the formulated recommendations is the necessity for a systematic assessment of the somatic and psychiatric condition of each patient with a paraphilic disorder undergoing ADT, in which cooperation between all multidisciplinary partners is important. The recommendations have the potential to reduce heterogeneity in clinical practice in Flanders and the Netherlands. Nevertheless, further research is required to clarify existing uncertainties and contradictions regarding certain follow-up parameters of ADT.
Eerste ervaringen met intensieve traumabehandeling in een forensische kliniek
Authors: Simjouw Annabel , de Bruijn Hanneke , Van Maris Leneke , Robbe Ester , Smid Wineke , de Vogel Vivienne
Published: October 2024

First experiences with intensive trauma treatment in a forensic psychiatric hospital

Within forensic populations, exposure to traumatic experiences is high. These experiences are associated with multiple mental and physical health problems later in life. Besides this, trauma may be a risk factor for the development of delinquent behavior and reduce responsiveness to forensic treatment. Treating trauma more specifically and intensively could potentially contribute to increasing the effect of forensic treatment and thus reducing the risk of recidivism. The expected symptom relief creates more room for the patient to participate in other treatment components within his or her program. Short-term, intensive trauma treatment appears to be more effective than long-term trauma treatment. This study describes the implementation, and first experiences with intensive trauma treatment within a forensic hospital. This treatment is a short-term trauma treatment consisting of eight days filled with Eye Movement Desensitization and Reprocessing (EMDR), Imaginary Exposure (IE), an activating sports and exercise program and psychoeducation. According to the experience of several patients and staff members, intensive trauma treatment appears to have a short-term effect on the trauma-related symptoms of patients who participate in this treatment. It is however still unclear whether these results are long-lasting. Implementing intensive trauma treatment takes time and requires extra efforts and investment from many different staff members. For a successful implementation it is important that this time is made available organization wide. The aftercare of patients after the intensive trauma treatment is crucial, and attention must be paid to the transition back to the regular program.
DEVELOPMENT SCENARIO SELECTION AND ORIENTATION PROPOSAL FOR KEY ECONOMIC SECTORS SUPPORTING THE STRATEGIC ENVIRONMENTAL ASSESSMENT OF DIEN BIEN PROVINCIAL PLANNING (2021-2030) WITH A VISION TO 2050
Authors: Doan Ha Phong  , Ta Thu Hang  , Doan Manh Hung  , Tran Viet Tung
Published: October 2024

The Strategic Environmental Assessment (SEA) for the "Dien Bien Provincial Planning for the 2021-2030 period, with a vision to 2050" is conducted on the basis of Viet Nam's legislative framework, national and regional planning, as well as the economic development orientation of Dien Bien province. In this article, potentially environmentally impacting content of the planning will be discussed, in which, development scenarios will be proposed and feasible scenario for the development of Dien Bien Province, the development targets, and orientations of important economic sectors will be selected. Three growth scenarios have been proposed for Dien Bien Province: the baseline scenario, the high growth scenario, and the breakthrough scenario. The most feasible one is the high growth scenario. In this scenario, the main specific targets by 2030 are: The average economic growth rate in the 2021-2030 period is 10.51%/year, in which the agriculture, forestry and fishery sector and the industry - construction sector will grow at the rate of 6.54% and 18.64%/year, respectively, in which the figure for the industry sector is 17.30%/year and that of the service sector is 7.15%/year. Regarding the economic structure by 2030, the agriculture, forestry and fishery sector will account for 12.0%; the industry - construction sector will account for 44.3% (in which the share of the industry sector is 15.4%) and the figure for the service sector is 39.6% of the province’s Gross National Produc (GRDP). The research oriented the development of a number of important sectors such as: industry, construction, tourism, trade and services, and agriculture, forestry and fishery. Selecting feasible development scenarios with specific targets will contribute significantly to proposing development orientations for sectors having great impacts on the environment to support the SEA of Dien Bien Provincial Planning for the 2021-2030 period, with a vision to 2050.
α-GLUCOSIDASE AND TYROSINASE INHIBITORY GUIDED ISOLATION, IDENTIFICATION OF MAJOR COMPOUND AND IN SILICO STUDY FROM EDIBLE MUSHROOM COPRINUS COMATUS
Authors: Poomsuk Nattawee , Dinawong Montira , Phimbupha Phonnapa , Wisetsai Awat , Pattumma Peerapat , Arthan Supakorn
Published: October 2024

Coprinus comatus is an edible and medicinal mushroom. The crude hexane, EtOAc and methanol extracts were extracted successively from C. Comatus. All the crude extracts were evaluated for anti-a-glucosidase and tyrosinase. The results showed that %inhibition valued for the crude hexane, EtOAc and methanol extracts of anti-a-glucosidase were 98.58 ± 0.09, 98.90 ± 0.21, and 6.68 ± 0.79, respectively. The anti-tyrosinase for the crude hexane, EtOAc and methanol extracts were 97.31 ± 2.77, 97.31 ± 3.34 and 64.94 ± 3.34, respectively. Notably, the bioassay-guided showed that the crude hexane and EtOAc were the highest for anti-a-glucosidase and tyrosinase activities, which led to the interest in purifying the major compound. The isolation and purification were successively done using chromatographic techniques. The pure compounds were determined by spectroscopic analysis (UV, FTIR, and NMR) and comparison with previously reported. The isolation led to three compounds (1-3), ergosterol (1), indole-3-carbaldehyde (2), and 4-hydroxybenzoic acid (3). The molecular docking of compounds 1-3, reported as α-glucosidase and tyrosinase inhibitors, was done by the AutoDockTools 1.5.6 (ADT) software. The results revealed that ergosterol (1) provides the highest binding free energy (-9.91 kcal/mol) to the active site of a-glucosidase, indicating that it is quite specific to this enzyme. Moreover, ergosterol (1) has strong binding energy (-9.64 kcal/mol) to tyrosinase but not significant tyrosinase specificity. This evidence supports that C. Comatus would be applicable for a functional food for controlling glucose blood levels.
DFT calculations of structural, chemical, electronic and thermodynamic properties of Rifampicin and Oxalic Acid
Authors: Soares Izzadora Quintanilha , Santana Audirene Amorim
Published: October 2024

The thermodynamic properties of the compounds contribute to the theoretical analysis of the results of favorable energies that are subject to interaction. In this work, through the DFT study, the comparison of the functionals ωB97XD and B3LYP. Geometry optimization calculations and vibrational frequencies were performed for the individual ions and for the interactions. In all cases, all calculated vibrational frequencies are positive, confirming the optimized geometry obtained as a minimum on the potential energy surface. The calculations were carried out in solvent, considering the solvation effect in methanol using the IEFPCM (Integral Equation Formalism of the Polarizable Continuum Model) method. The present work aims to carry out a theoretical study, for in-depth investigations of structural, electronic and thermodynamic properties. In usability in the calculation of the thermodynamic properties, Rifampicin (RIF) and Oxalic Acid (OXA) and the interaction between RIF-OXA in the protonated form protonated RIF with charge +1 and deprotonated OXA with charge -1. In this context, the most favorable thermodynamic parameters in the interaction calculated RIF+-OXA- the values of ∆EZPVE+BSSE, ∆G298 and ∆H in kcal/mol more favorable are -19.62, -14.81 and -25,77.