bluuebunny/crossref_metadata_2025 huggingface dataset:
Recombinant Interleukin‐1 Receptor Antagonist Is an Effective First‐Line Treatment Strategy in New‐Onset Systemic Juvenile Idiopathic Arthritis, Irrespective of HLA‐DRB1 Background and IL1RN Variants
Authors: Erkens Remco G. A. , Calis Jorg J. A. , Verwoerd Anouk , De Roock Sytze , Ter Haar Nienke M. , Den Engelsman Gerda , Van der Veken Lars T. , Ernst Robert F. , Van Deutekom Hanneke W. M. , Pickering Alex , Scholman Rianne C. , Jansen Marc H. A. , Swart Joost F. , Sinha Rashmi , Roth Johannes , Schulert Grant S. , Grom Alexei A. , Van Loosdregt Jorg , Vastert Sebastiaan J.
Published: July 2023

Objective

Human leukocyte antigen (HLA)‐DRB1*15:01 has been recently associated with interstitial lung disease (LD), eosinophilia, and drug reactions in systemic juvenile idiopathic arthritis (sJIA). Additionally, genetic variants in IL1RN have been linked to poor response to anakinra. We sought to reproduce these findings in a prospective cohort study of patients with new‐onset sJIA treated with anakinra as first‐line therapy.

Methods

HLA and IL1RN risk alleles were identified via whole‐genome sequencing. Treatment responses and complications were compared between carriers versus noncarriers.

Results

Seventeen of 65 patients (26%) carried HLA‐DRB1*15:01, comparable with the general population, and there was enrichment for HLA‐DRB1*11:01, a known risk locus for sJIA. The rates of clinical inactive disease (CID) at 6 months, 1 year, and 2 years were generally high, irrespective of HLA‐DRB1 or IL1RN variants, but significantly lower in carriers of an HLA‐DRB1*11:01 allele. One patient, an HLA‐DRB1*15:01 carrier, developed sJIA‐LD. Of the three patients with severe drug reactions to biologics, one carried HLA‐DRB1*15:01. The prevalence of eosinophilia did not significantly differ between HLA‐DRB1*15:01 carriers and noncarriers at disease onset (6.2% vs 14.9%, P = 0.67) nor after the start of anakinra (35.3% vs 37.5% in the first 2 years of disease).

Conclusion

We observed high rates of CID using anakinra as first‐line treatment irrespective of HLA‐DRB1 or IL1RN variants. Only one of the 17 HLA‐DRB1*15:01 carriers developed sJIA‐LD, and of the three patients with drug reactions to biologics, only one carried HLA‐DRB1*15:01. Although thorough monitoring for the development of drug hypersensitivity and refractory disease courses in sJIA, including sJIA‐LD, remains important, our data support the early start of biologic therapy in patients with new‐onset sJIA irrespective of HLA‐DRB1 background or IL1RN variants.

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Multigraft Copolymers from an Upscalable Synthesis Route — Material Characteristics and Application Relevant Performance
Authors: Schlegel Ralf , Budde Hendrik , Mahmood Nasir , Wendler Ulrich , Bartke Michael , Beiner Mario
Published: July 2023

Tetrafunctional multigraft copolymers (MGCP) based on polyisoprene (PI) and polystyrene (PS) are prepared by an upscalable pilot‐scale anionic synthesis approach, prospectively making this new type of thermoplastic elastomers available for future industrial applications. The materials are characterized with respect to their molecular architecture, microphase‐separated morphology, their thermal and mechanical properties under quasi‐static conditions as well as regarding the damage behavior under dynamic deformation. For the latter, membrane demonstrators are prepared by melt pressing. The investigated multigraft copolymers show strain at break values between 1250 % and 2000 %, depending on the number of branch points, in connection with tensile strength values of 17 to 8 N mm−2, respectively. Their ultimate toughness is about 50 % higher than that of a reference diblock–triblock blend with similar chemical composition. They show superior behavior in hysteresis tests at large number of hysteresis cycles. Application relevant testing revealed that melt‐pressed multigraft copolymer membranes are less affected by surface cracks after long term dynamic testing in comparison to the reference copolymer blend. Based on this property profile, multigraft copolymer‐based thermoplastic elastomers can be considered as suitable candidates to substitute components made from silicon and polyvinyl chloride (PVC). Further, they can serve as more effective toughening additives in blends.
The Justice for Victims of War Crimes Act (U.S.)
Authors: Pearlman Adam R.
Published: July 2023

On January 5, 2023, the U.S. Justice for Victims of War Crimes (JVWC) Act was signed into law. The legislation closed long-recognized gaps in U.S. federal jurisdiction for holding accused war criminals accountable. Prior to the JVWC, the federal war crimes statute provided jurisdiction over war crime offenses committed anywhere, but only if the victim or offender was a member of the U.S. Armed Forces or a U.S. national. The baseline federal statute of limitations also applied, meaning the United States could only bring charges within five years of the crime occurring.
Longitudinal analysis of the Alternative Healthy Eating Index-2010 and incident non-communicable diseases over 15 years in the 1973–1978 cohort of the Australian Longitudinal Study on Women’s Health
Authors: Hlaing-Hlaing Hlaing , Dolja-Gore Xenia , Tavener Meredith , Hure Alexis J.
Published: July 2023

In studies that contain repeated measures of variables, longitudinal analysis accounting for time-varying covariates is one of the options. We aimed to explore longitudinal association between diet quality (DQ) and non-communicable diseases (NCDs). Participants from the 1973–1978 cohort of the Australian Longitudinal Study on Women’s Health (ALSWH) were included, if they; responded to survey 3 (S3, 2003, aged 25–30 years) and at least one survey between survey 4 (S4, 2006) and survey 8 (S8, 2018), were free of NCDs at or before S3, and provided dietary data at S3 or S5. Outcomes were coronary heart disease (CHD), hypertension (HT), asthma, cancer (except skin cancer), diabetes mellitus (DM), depression and/or anxiety, and multimorbidity (MM). Longitudinal modelling using generalised estimation equation (GEE) approach with time-invariant (S4), time-varying (S4–S8) and lagged (S3–S7) covariates were performed. The mean (± standard deviation) of Alternative Healthy Eating Index-2010 (AHEI-2010) of participants (n = 8022) was 51·6 ± 11·0 (range: 19–91). Compared to women with the lowest DQ (AHEI-2010 quintile 1), those in quintile 5 had reduced odds of NCDs in time-invariant model (asthma: OR (95 % CI): 0·77 (0·62–0·96), time-varying model (HT: 0·71 (0·50–0·99); asthma: 0·62 (0·51–0·76); and MM: 0·75 (0·58–0·97) and lagged model (HT: 0·67 (0·49–0·91); and asthma: 0·70 (0·57–0·85). Temporal associations between diet and some NCDs were more prominent in lagged GEE analyses. Evidence of diet as NCD prevention in women aged 25–45 years is evolving, and more studies that consider different longitudinal analyses are needed.
Homologous recombination mRNAs (RAD21, RAD50 and BARD1) have a potentially poor prognostic role in ERBB2-low bladder cancer patients
Authors: Albarakati Nada , Al-Ghamdi Hanin , Al-Sowayan Batla , Alshareeda Alaa
Published: July 2023

Human epidermal growth factor receptor 2 (HER2/ERBB2) factor is known to be implicated in many malignancies and the potential of it as a prognostic biomarker was reported years ago. Molecular subtypes of HER2/ERBB2 negative and positive with distinct clinical outcomes have been identified in recent years; however, it is still under investigation for bladder cancer. This study evaluates the biological and prognostic significance of RAD21, RAD50 and BARD1 (homologous recombination biomarkers) mRNA levels with ERBB2 low and high expression to explore their impact on bladder cancer patient survival and cancer aggressiveness. The expression of ERBB2, RAD21, RAD50 and BARD1 mRNA levels was assessed in The Cancer Genome Atlas (TCGA) bladder cancer dataset along with four validation cohorts. Outcome analysis was evaluated using disease-free survival (DFS) and overall survival (OS). Univariate and multivariate analysis were used to evaluate the relationship between RAD21, RAD50, BARD1 and ERBB2 expression and clinicopathological variables. A significant increase in mRNA expression levels of RAD21, RAD50 and BARD1 was noticed in ERBB2-low patients compared to ERBB2-high patients. This overexpression of the homologous recombination repair transcripts was associated with poor outcome in ERBB2-low tumors, not in ERBB2-high tumors. Furthermore, the combined expression of high RAD21/RAD50, high RAD21/BARD1 or high RAD50/BARD1 were significantly associated with worse DFS and a better outcome for those with low co-expression in the ERBB2-low cohort. High expression of either RAD21/RAD50 or RAD21/BARD1 in ERBB2-low cohort associated with higher chance of metastasis. In addition, gene expression of BARD1 alone or in combination with RAD50 acted as an independent prognostic factor for worst survival. The data presented in this study reveal a connection between RAD21, RAD50, BARD1 and ERBB2 and patient survival. Importantly, it provided novel findings and potential prognostic markers, particularly in ERBB2-low bladder cancer.
Versorgung von Dialysepatienten gefährdet
Authors: Roland Katharina
Published: July 2023

Der Verband Deutsche Nierenzentren (DN) e. V. hat am 22.05.2023 einen Brandbrief an die Bundesverbände der Krankenkassen versendet. Damit will der Berufsverband auf die prekäre Situation in der ambulanten Nephrologie aufmerksam machen. Die Mitgliedspraxen des Verbands leiden unter enormen Kostensteigerungen, die durch den jüngsten Verdi-Tarifabschluss weiter verschärft werden. Die Versorgungsqualität von chronisch Nierenkranken ist mittlerweile stark gefährdet. Der Verband fordert daher von den Krankenkassen einen Ausgleich für die steigenden Kosten seiner Mitglieder.
Convergence guarantees for coefficient reconstruction in PDEs from boundary measurements by variational and Newton-type methods via range invariance
Authors: Kaltenbacher Barbara
Published: July 2023

A key observation underlying this paper is the fact that the range invariance condition for convergence of regularization methods for nonlinear ill-posed operator equations—such as coefficient identification in partial differential equations (PDEs) from boundary observations—can often be achieved by extending the searched for parameter in the sense of allowing it to depend on additional variables. This clearly counteracts unique identifiability of the parameter, though. The second key idea of this paper is now to restore the original restricted dependency of the parameter by penalization. This is shown to lead to convergence of variational (Tikhonov type) and iterative (Newton-type) regularization methods. We concretize the abstract convergence analysis in a framework typical of parameter identification in PDEs in a reduced and an all-at-once setting. This is further illustrated by three examples of coefficient identification from boundary observations in elliptic and time-dependent PDEs.
Computational Sentiment Analysis
Authors: Ophir Yotam , Walter Dror
Published: July 2023

This chapter reviews the state of the field of automated sentiment analysis and draws recommendations for available methods and best practices for communication scholars. Introducing and explaining novel methods, from simple dictionary-based approaches to more sophisticated machine learning algorithms, the authors examine the past, present, and potential future of automated sentiment analysis and critically discuss its benefits and limitations, with a particular focus on issues of validity. Acknowledging these important caveats, they discuss the vast potential of big data and computational methods to advance knowledge and theories of emotional communications and demonstrate its applicability using real-world studies of sentiment analysis in communication research.
In vitro safety and efficacy of probiotics mixture
on carbohydrate digestion inhibition
Authors: Seo Eunsol , Woo Jang-Bin , Seo MinYeong , Woo Jeongmin
Published: July 2023

This study aimed to assess the in vitro safety of a probiotics
mixture (Lactobacillus acidophilus PBS066,
Lactiplantibacillus plantarum PBS067, and
Limosilactobacillus reuteri PBS072), along with its
inhibitory effect on carbohydrate digestion. All three strains met the
antibiotic resistance profile of the European Food Safety Authority (EFSA)
guidelines. None of the strains exhibited hemolytic activity or cytotoxicity
against Caco-2 cells. Strains PBS067 and PBS072 inhibited
α-amylase activity, whereas all three strains
suppressed α-glucosidase activity, indicating that the
mixture might limit carbohydrate digestion in the gastrointestinal tract. These
findings support the safety of this probiotics mixture and its potential to
modulate carbohydrate metabolism in the gut.
A novel homozygous missense variant in TBC1D31 in a consanguineous family with congenital anomalies of the kidney and urinary tract (CAKUT)
Authors: Saygılı Seha , Koşukcu Can , Baştuğ Turgut , Doğan Özlem Akgün , Yılmaz Esra Karabağ , Kalyoncu Ayşe Uçar , Ağbaş Ayşe , Canpolat Nur , Çalışkan Salim , Ozaltin Fatih
Published: July 2023

Congenital anomalies of the kidney and urinary tract (CAKUT) is the leading cause of chronic kidney disease in the first three decades of life. Until now, more than 180 monogenic causes of isolated or syndromic CAKUT have been described. In addition, copy number variants (CNV) have also been implicated, however, all of these causative factors only explain a small fraction of patients with CAKUT, suggesting that additional yet‐to‐be‐discovered novel genes are present. Herein, we report three siblings (two of them are monozygotic twin) of a consanguineous family with CAKUT. Whole‐exome sequencing identified a homozygous variant in TBC1D31. Three dimensional protein modeling as well as molecular dynamics simulations predicted it as pathogenic. We therefore showed for the first time an association between a homozygous TBC1D31 variant with CAKUT in humans, expanding its genetic spectrum.
Novel mutations in FLVCR1 cause tremors, sensory neuropathy with retinitis pigmentosa
Authors: Li Zhenyu , Li Yize , Chu Xujun , Du Kang , Tang Yuwei , Xie Zhiying , Yu Meng , Deng Jianwen , Lv He , Zhang Wei , Wang Zhaoxia , Meng Lingchao , Yuan Yun
Published: July 2023

The mutations of the feline leukemia virus subgroup C receptor‐related protein 1 (FLVCR1) cause ataxia with retinitis pigmentosa. Recent studies indicated a large variation in the phenotype of FLVCR1‐associated diseases. In this report, we describe an adult male who manifested first with tremors in his third decade, followed by retinitis pigmentosa, sensory ataxia, and sensory neuropathy in his fourth decade. While retinitis pigmentosa and sensory ataxia are well‐recognized features of FLVCR1‐associated disease, tremor is rarely described. Whole‐exome sequencing revealed novel compound heterozygous pathogenic FLVCR1 variants: c.498 G > A; p.(Trp166*) and c.369 T > G; p.(Phe123Leu). In addition, we have highlighted the ultrastructural abnormalities of the sural biopsy in this patient.
A Quad-Port Design of a Bow-Tie Shaped Slot Loaded Wideband (24.2–30.8GHz) MIMO Antenna Array for 26/28GHz mm-Wave 5G NR n257/n258/n260 Band Applications
Authors: Ghazaoui Yousra , EL Ghzaoui Mohammed , Das Sudipta , Madhav Boddapati Taraka Phani , Islam Tanvir , Seddik Bri
Published: July 2023

This paper describes a four-port MIMO antenna array design featuring bow-tie-shaped slot-loaded patches with wideband capabilities that cover the frequency range from 24.2[Formula: see text]GHz to 30.8[Formula: see text]GHz. The proposed antenna design is printed on an FR4 substrate and occupies an area of 25[Formula: see text]×[Formula: see text]24[Formula: see text]mm2. The MIMO antenna consists of four antenna arrays that are symmetrically placed in an upper-lower configuration. The bow-tie-shaped slots loaded radiators are separated horizontally by 3.48[Formula: see text]mm and vertically by 5.94[Formula: see text]mm. Each antenna array contains two elements that are separated by a distance of wavelength/4. The suggested MIMO antenna array delivers a high gain of 19.09[Formula: see text]dB at 27.8[Formula: see text]GHz and has a bandwidth of 6.6[Formula: see text]GHz that covers the frequency band of 24.2–30.8[Formula: see text]GHz. The research demonstrates the quality of the proposed MIMO antenna through various diversity parameters such as mutual coupling, port correlation, diversity gain, and data rate that can be transmitted over a communication medium. The simulation results are validated and found to be consistent with the experimental results. The presented antenna covers the entire bandwidth allocated to different regions, including Europe (24.25–27.5[Formula: see text]GHz), Sweden (26.5–27.5[Formula: see text]GHz), USA (27.5–28.35[Formula: see text]GHz), China (24.25–27.5[Formula: see text]GHz), Japan (27.5–28.28[Formula: see text]GHz), and Korea (26.5–29.5[Formula: see text]GHz). The proposed MIMO antenna design could be an excellent option for 26/28[Formula: see text]GHz 5G NR n257, n258, and n260 bands under mm-wave wireless communication systems.
Supplementary Table S1 from Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Authors: Gray Jhanelle E. , Ahn Myung-Ju , Oxnard Geoffrey R. , Shepherd Frances A. , Imamura Fumio , Cheng Ying , Okamoto Isamu , Cho Byoung Chul , Lin Meng-Chih , Wu Yi-Long , Majem Margarita , Gautschi Oliver , Boyer Michael , Bulusu Krishna C. , Markovets Aleksandra , Barrett J. Carl , Hodge Rachel , McKeown Astrid , Hartmaier Ryan J. , Chmielecki Juliann , Papadimitrakopoulou Vassiliki A. , Ramalingam Suresh S.
Published: July 2023

Representativeness of study participants
Supplementary Figure S4 from Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Authors: Gray Jhanelle E. , Ahn Myung-Ju , Oxnard Geoffrey R. , Shepherd Frances A. , Imamura Fumio , Cheng Ying , Okamoto Isamu , Cho Byoung Chul , Lin Meng-Chih , Wu Yi-Long , Majem Margarita , Gautschi Oliver , Boyer Michael , Bulusu Krishna C. , Markovets Aleksandra , Barrett J. Carl , Hodge Rachel , McKeown Astrid , Hartmaier Ryan J. , Chmielecki Juliann , Papadimitrakopoulou Vassiliki A. , Ramalingam Suresh S.
Published: July 2023

Assessment of correlation between EGFRm VAF in baseline plasma and investigator-assessed PFS in A, patients from the AURA3 trial, by treatment arm and B, patients from the FLAURA trial, by treatment arm. Abbreviations: CR, complete response; EGFRm, epidermal growth factor receptor mutation (ex19del or L858R); NE, not evaluable; PD, progressive disease; PFS, progression-free survival; PR, partial response; SD, stable disease; VAF, variant allelic fraction.
Supplementary Figure S2 from Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Authors: Gray Jhanelle E. , Ahn Myung-Ju , Oxnard Geoffrey R. , Shepherd Frances A. , Imamura Fumio , Cheng Ying , Okamoto Isamu , Cho Byoung Chul , Lin Meng-Chih , Wu Yi-Long , Majem Margarita , Gautschi Oliver , Boyer Michael , Bulusu Krishna C. , Markovets Aleksandra , Barrett J. Carl , Hodge Rachel , McKeown Astrid , Hartmaier Ryan J. , Chmielecki Juliann , Papadimitrakopoulou Vassiliki A. , Ramalingam Suresh S.
Published: July 2023

Correlation between EGFRm allelic fraction at baseline by ddPCR (Biodesix) and NGS (Guardant Health) analyses in A, patients from the AURA3 trial (n = 202) and B, patients from the FLAURA trial (n = 347). Abbreviations: ddPCR, droplet digital PCR; EGFRm, epidermal growth factor receptor mutation (ex19del or L858R); NGS, next-generation sequencing.
Endoscopic and Surgical Management of Non-Metastatic Ampullary Neuroendocrine Neoplasia: A Multi-Institutional Pancreas2000/EPC Study
Authors: Karam Elias , Hollenbach Marcus , Abou Ali Einas , Auriemma Francesco , Anderloni Andrea , Barbier Louise , Belfiori Giulio , Caillol Fabrice , Crippa Stefano , Del Chiaro Marco , De Ponthaud Charles , Dahel Yanis , Falconi Massimo , Giovannini Marc , Heling Dominik , Inoue Yosuke , Jarnagin William R. , Leung Galen , Lupinacci Renato M. , Mariani Alberto , Masaryk Viliam , Miksch Rainer Christoph , Musquer Nicolas , Napoleon Bertrand , Oba Atsushi , Partelli Stefano , Petrone Maria C. , Prat Frédéric , Repici Alessandro , Sauvanet Alain , Salzmann Katrin , Schattner Mark A. , Schulick Richard , Schwarz Lilian , Soares Kevin , Souche François R. , Truant Stéphanie , Vaillant Jean C. , Wang Tiegong , Wedi Edris , Werner Jens , Weismüller Tobias J. , Wichmann Dörte , Will Uwe , Zaccari Piera , Gulla Aiste , Heise Christian , Regner Sara , Gaujoux Sébastien ,   Pancreas 2000 Research Group
Published: July 2023

Introduction: Ampullary neuroendocrine neoplasia (NEN) is rare and evidence regarding their management is scarce. This study aimed to describe clinicopathological features, management, and prognosis of ampullary NEN according to their endoscopic or surgical management. Methods: From a multi-institutional international database, patients treated with either endoscopic papillectomy (EP), transduodenal surgical ampullectomy (TSA), or pancreaticoduodenectomy (PD) for ampullary NEN were included. Clinical features, post-procedure complications, and recurrences were assessed. Results: 65 patients were included, 20 (30.8%) treated with EP, 19 (29.2%) with TSA, and 26 (40%) with PD. Patients were mostly asymptomatic (n = 46; 70.8%). Median tumor size was 17 mm (12–22), tumors were mostly grade 1 (70.8%) and pT2 (55.4%). Two (10%) EP resulted in severe American Society for Gastrointestinal Enterology (ASGE) adverse post-procedure complications and 10 (50%) were R0. Clavien 3–5 complications did not occur after TSA and in 4, including 1 postoperative death (15.4%) of patients after PD, with 17 (89.5%) and 26 R0 resection (100%), respectively. The pN1/2 rate was 51.9% (n = 14) after PD. Tumor size larger than 1 cm (i.e., pT stage >1) was a predictor for R1 resection (p < 0.001). Three-year overall survival and disease-free survival after EP, TSA, and PD were 92%, 68%, 92% and 92%, 85%, 73%, respectively. Conclusion: Management of ampullary NEN is challenging. EP should not be performed in lesions larger than 1 cm or with a endoscopic ultrasonography T stage beyond T1. Local resection by TSA seems safe and feasible for lesions without nodal involvement. PD should be preferred for larger ampullary NEN at risk of nodal metastasis.
Efficient algorithms for big data management
Authors: Δρίτσας Ηλίας
Published: July 2023

Στο πλαίσιο της διδακτορικής έρευνας, ασχολήθηκα με προβλήματα διαχείρισης δεδομένων αναπτύσσοντας μεθόδους και τεχνικές που, αφενός, διατηρούν ή βελτιώνουν το απόρρητο και την ανωνυμία των χρηστών και, αφετέρου, είναι αποτελεσματικές από άποψη χρόνου και αποθήκευσης χώρου για μεγάλου όγκου βάσεις δεδομένων. Τα ερευνητικά αποτελέσματα της εργασίας επικεντρώνονται στα εξής: Αξιολόγηση της απόδοσης των ερωτημάτων σε μια βάση δεδομένων μεγάλου όγκου χρησιμοποιώντας ή όχι τη δομή Bloom Filter. Αξιολόγηση το χρόνο φόρτου εργασίας, τη μνήμη και τη χρήση του δίσκου του προβλήματος Διατήρησης Απορρήτου Σύνδεση Εγγραφής (PPRL) στο Hadoop MapReduce Framework. Μέθοδοι απάντησης ερωτημάτων των πλησιέστερων γειτόνων σε χωροχρονικά δεδομένα (κινούμενες τροχιές χρηστών) προκειμένου να διατηρηθεί η ανωνυμία, όπου τα ερωτήματα εφαρμόζονται σε ομαδοποιημένα ή μη δεδομένα. Χρησιμοποιήθηκε η μέθοδος k ανωνυμίας, όπου, το σύνολο ανωνυμίας με το οποίο "καμουφλάρεται" κάθε κινούμενο αντικείμενο της χωροχρονικής βάσης δεδομένων, αποτελείται από τους k πλησιέστερους γείτονές του. Η ευρωστία της μεθόδου ποσοτικοποιήθηκε με πιθανότητα 1/k και μελετήθηκε η επίδραση της διαστάσεων και της συσχέτισης των δεδομένων στη διατήρηση της ανωνυμίας και της ιδιωτικότητας. Η παραπάνω μέθοδος βελτιώθηκε από την άποψη της αποτελεσματικής αποθήκευσης χωροχρονικών δεδομένων με την εφαρμογή ερωτημάτων των πλησιέστερων γειτόνων στις μετασχηματισμένες μη γραμμικές τροχιές κινούμενων αντικειμένων κατά Hough. Επιπλέον γίνεται εφαρμογή ασφαλών ερωτημάτων k-NN αξιολογήθηκε στο περιβάλλον GeoSpark, ανάλυση συναισθήματος σε δεδομένα Twitter και προβλέψεις για τον τουρισμό στο Apache Spark περιβάλλον.
Competitiveness of Entrepreneurs and Salaried Workers
Authors: Balafoutas Loukas , Batsaikhan Mongoljin , Sutter Matthias
Published: July 2023

We measure the willingness to compete of entrepreneurs and salaried workers in an experiment. Participants can choose between a piece rate and a tournament scheme in either private or public. We find that in the private condition, entrepreneurs are less competitive than salaried workers, but in the public condition, this ordering is reversed. Survey data suggest that perceived norms of appropriate behavior, along with beliefs about the instrumental value of competitiveness for professional success, can explain why entrepreneurs are more competitive when decisions are publicly observable. We also find that the latter condition improves the quality of experimental decisions.

This paper was accepted by Yan Chen, behavioral economics and decision analysis.

Funding: Financial support from the Deutsche Forschungsgemeinschaft (German Research Foundation) under Germany´s Excellence Strategy [Grant EXC 2126/1–390838866], the University of Cologne through the Hans Kelsen Prize and the Austrian Science Fund through the Special Research Area [Grant SFB F63] is gratefully acknowledged.

Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4838 .
Corporate Social Responsibility strategy for PT Pertamina Sungai Pakning community empowerment during the Covid-19 pandemic
Authors: Dewi damaiyanti Sherlly Dewi Damaiyanti
Published: July 2023

This paper aims to identify CSR analysis strategies at PT Pertamina Sungai Pakning in Community Empowerment during the Covid-19 Pandemic, especially in the section on community empowerment as social responsibility in the company. The method used in this study is qualitative with a description of the analysis to be able to provide an overview of the subject matter to be studied. The results of this study are corporate social responsibility activities in tackling the pandemic using three strategies, namely donations, capacity building and community empowerment. This third strategy is able to answer the needs of the community and encourage the establishment of synergy between companies and government agencies in efforts to overcome the pandemic. CSR during the Covid-19 pandemic has a great opportunity to release its best innovations in making meaningful social contributions as a form of long-term development on a balance between profitability and harmony with various stakeholders.
Palliative care to improve life with alcohol related liver cirrhosis: a systematic review
Authors: Christensen Dorthe Wiinholdt , Heerfordt Astrid Stidsing , Schiødt Frank Vinholt , Simonsen Mette Kildevæld
Published: July 2023

Liver cirrhosis is a chronic, life-threatening disease. Studies show that the 1-year mortality rate is 57%. According to the World Health Organization, palliative care can improve the quality of life for patients with liver cirrhosis, reduce unnecessary hospital admissions and lower healthcare costs. However, there is limited research on the use of palliative care in patients with liver cirrhosis. Four studies were identified that explored interventions conducted for patients with alcohol related liver cirrhosis related to palliation. Three studies also examined the experiences of patients, relatives, and professionals with palliation. Three themes emerged from the examination of these articles: organisational structure, lack of knowledge, and anxiety about discussing the subject.
A Global Dimension Theorem For C *-Algebras
Authors: Rosbotham Michael
Published: July 2023

Abstract: For a C* -algebra A , we consider a cohomological dimension that naturally arises from a category of operator space modules over A . We demonstrate how some classical results, such as an extension theorem of Wittstock, can be utilised to arrive at a lower bound for this dimension.
Real-time classification of longitudinal conveyor belt cracks with deep-learning approach
Authors: Dwivedi Uttam Kumar , Kumar Ashutosh , Sekimoto Yoshihide
Published: July 2023

Long tunnels are a necessary means of connectivity due to topological conditions across the world. In recent years, various technologies have been developed to support construction of tunnels and reduce the burden on construction workers. In continuation, mountain tunnel construction sites especially pose a major problem for continuous long conveyor belts to remove crushed rocks and rubbles out of tunnels during the process of mucking. Consequently, this process damages conveyor belts quite frequently, and a visual inspection is needed to analyze the damages. Towards this, the paper proposes a model to configure the damage and its size on conveyor belt in real-time. Further, the model also localizes the damage with respect to the length of conveyor belt by detecting the number markings at every 10 meters of the belt. The effectiveness of the proposed framework confirms superior real-time performance with optimized model detecting cracks and number markings with mAP of 0.850 and 0.99 respectively, while capturing 15 frames per second on edge device. The current study marks and validates the versatility of deep learning solutions for mountain tunnel construction sites.
Distribution characteristics of FcμR positive cells in small intestinal lymph nodes of Bactrian camel
Authors: Fei Xie , Li Jian fei , Fang Ying dong , Liu Li ping , Liu Ke Jiang , Zeng Wei wei , Wang Wen hui
Published: July 2023

Exploring the expression characteristics of FcμR in small intestinal lymph nodes of bactrian camels can lay the foundation for further revealing the function of FcμR. The FcμR expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immunohistochemical staining and statistical analysis. FcμR positive cells were mainly located in the lymphoid follicles and their numbers decreased in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes, and the number of positive cells was statistically significant between different intestinal segments (P<0.05). The FcμR is expressed in lymphoid follicular B cells, which not only facilitates the body’s ability to regulate secretory IgM levels, but also acts as a local immune defence barrier. The small intestine has dual functions of immune tolerance and immune response, the proximal part mainly focuses on immune tolerance, and the distal part mainly focuses on immune response. This distribution ensures the unity of the duodenal absorption and immune defence, and also significantly increases the efficiency of the entire small intestine, which is why the number of FcμR positive cells decreases in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes.
Reflexões acerca da violência psicológica contra a mulher
Authors: De Alcantara Savazzoni Simone
Published: July 2023

Sabido que a violência psicológica contra a mulher provoca nefastas consequências com efeito destruidor para as vítimas, vulnerando flagrantemente direitos fundamentais, o presente artigo aborda essa temática no âmbito disciplinado pela Lei nº 14.188/2021, a qual incluiu o artigo 147-B no Código Penal, para tipificar essa conduta como crime. Mediante aplicação da metodologia da pesquisa bibliográfica com abordagem qualitativa, o escopo deste trabalho consiste em refletir acerca das perspectivas da tutela penal disciplinada pela novel legislação, sem perder de vista o questionamento sobre a necessidade de uma abordagem global para romper o perverso ciclo vicioso de violência perpetrado contra a mulher no Brasil. Nesse desiderato, inicialmente, apresenta-se o tratamento da matéria antes da promulgação da recente alteração legislativa. Para, então, examinar especificamente os termos da inclusão do artigo 147-B no Código Penal, com o propósito de verificar os principais aspectos relativos ao sujeito do delito, ao rol de condutas, à prova do dano emocional. Deveras, o objetivo da discussão é compreender como a criminalização da violência psicológica colabora com a busca de proteção integral da mulher. Nesse prisma, denota-se imperioso reconhecer que a questão é extremamente abrangente e depende de várias frentes de atuação, não desmerecendo de maneira alguma a iniciativa legislativa da tipificação penal instituída pela Lei nº 14.188/2021, a qual também se configura como um marco importante. Entretanto, certamente, a penalização não pode ser encarada como uma medida isolada, sendo primordial instrumentalizar outras políticas públicas efetivas para uma real valorização da mulher em todos os âmbitos e ambientes, de forma a vencer estereótipos históricos e culturais arraigados. Para tanto, além da atuação do aparato estatal, a sociedade também precisa protagonizar essa mudança de paradigma, com compromisso ético e ativo, a fim de que efetivamente sejam garantidos à mulher os direitos humanos fundamentais de uma vida livre e digna, superando sua vitimização ancestral pela discriminação, violência e exclusão, no âmbito familiar, estatal e social.
Regionale Innovationsförderung im Vergleich
Authors: Hassink Robert
Published: July 2023

Die Regionalpolitik und Technologiepolitik wachsen im Europa der Regionen mehr und mehr zusammen. Wenn man die Technologietransfernetzwerke in Nordost-England, im Ruhrgebiet und in Baden-Württemberg miteinander vergleicht, wird deutlich, daß der nationale politische Rahmen stark auf den Spielraum der Regionen einwirkt, um selber eine Innovationsförderung zu entwickeln. Die Region mit den größten politischen Gestaltungsmöglichkeiten, Baden-Württemberg, hat sich das durchsichtigste Netzwerk geschaffen. In Nordost-England sind gleichzeitig Initiativen sowohl auf regionaler Ebene als auch auf nationaler Ebene entstanden, ohne daß die Initiativen aufeinander abgestimmt worden sind. Dadurch überlappen die verschiedenen innovationsfördernden Aktivitäten einander.
Nachhaltige Nutzung: Mehr als ein neues Schlagwort?
Authors: Haber Wolfgang
Published: July 2023

Das Konzept der „Nachhaltigkeit“ wird in seiner historischen Entwicklung – von einem forstwirtschaftlichen Konzept bis zu einer der Grundlagen internationaler Umweltpolitik – beschrieben und auf seine Realisierbarkeit aus ökologischer Sicht geprüft. Allen natürlichen Ökosystemen kommt die Eigenschaft „Nachhaltigkeit“ zu, obwohl sie ganz unterschiedlich mit verfügbaren Ressourcen ausgestattet sind und auch Veränderungen (Sukzession) offenstehen. Durch z. T. weltweite Ressourcen-Verschiebungen und Entwicklungs-Beschleunigungen hat der Mensch das gewachsene Ordnungsgefüge der Biosphäre irreversibel verändert. Durch die Einführung des Nachhaltigkeits-Konzepts sind zwar Korrekturen dieser Änderungen, vor allem im regionalen Rahmen möglich (und notwendig), aber keine grundlegende Neuordnung.
Der Kohäsionsfonds: Ein strukturpolitisches Finanzinstrument der Europäischen Union
Authors: Binder Klaus Georg , Walthes Frank
Published: July 2023

Mit dem Kohäsionsfonds hat die Europäische Union (EU) ein weiteres strukturpolitisches Instrument geschaffen, um den wirtschaftlichen und sozialen Zusammenhalt in der Gemeinschaft zu fördern. Es werden Vorhaben in den Bereichen Umwelt und transeuropäische Netze auf dem Gebiet der Verkehrsinfrastruktur finanziell unterstützt. Als förderungswürdig gelten diejenigen Länder, welche ein in Kaufkraftstandards gemessenes Bruttosozialprodukt pro Kopf von weniger als 90 % des Gemeinschaftsdurchschnitts erreichen. Die finanzielle Vorausschau für die Jahre 1993 bis 1999 sieht für den Kohäsionsfonds insgesamt 15,15 Mrd. ECU (über 30 Mrd. DM) vor. Regionaltheoretische Aspekte der Verkehrsinfrastruktur und umweltökonomische Gesichtspunkte in ihren globalen und regionalen Ausprägungen zeigen, daß der Kohäsionsfonds unter bestimmten Bedingungen sowohl aus allokativer als auch distributiver Sicht durchaus sinnvoll sein kann.
Galeria Waleria – kobieta, która chciała sama decydować o sobie. Kobieta a legitymizacja władzy w dobie tetrarchii
Authors:   Uniwersytet w Białymstoku, Suski Robert
Published: July 2023

O cesarzowych, żonach cesarzy w drugiej połowie III i początku IV w. nie wiadomo zbyt dużo. Najczęściej były one igraszkami w rękach mężczyzn-cesarzy. Do wyjątków należała Galeria Waleria. Była ona córką cesarza Dioklecjana oraz żoną Galeriusza. Według Laktancjusza po śmierci męża została oddana przez swojego zmarłego męża pod opiekę jego przyjaciela – Licyniusza. Jednak uciekła do jego rywala Maksymina Dai, gdyż miała się obawiać, że Licyniusz będzie chciał wymusić na niej małżeństwo. Następnie odrzuciła propozycję małżeństwa ze strony Maksymina Dai, za co została skazana na wygnanie. Po upadku Maksymina Dai i zagarnięciu jego ziem przez Licyniusza została skazana na śmierć przez zwycięzcę. W świetle tych informacji widzimy, że Waleria nie chciała jedynie podporządkować się woli mężczyzn, ale sama chciała decydować o sobie, za co ostatecznie zapłaciła bardzo wysoką cenę.
Pisarki, poetki, bohaterki… – siedleckie badania literaturoznawcze
Authors:   Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach, Walęciuk-Dejneka Beata
Published: July 2023

Artykuł poświęcony jest badaniom literaturoznawczym dotyczącym problematyki kobiet/kobiecej, prowadzonym od ponad 10 lat w Instytucie Językoznawstwa i Literaturoznawstwa na Uniwersytecie Przyrodniczo-Humanistycznym w Siedlcach. Pokazuje również kierunki tych badań, które są ujęte w perspektywie zarówno naukowej, jak i popularyzującej. W ramach badań nad twórczością kobiet – pisarek, poetek, a także bohaterek utworów literatury, głównie polskiej, powstały w ośrodku trzy serie wydawnicze: 1. Literackie Portrety Kobiet. Antologia, t. 1, 2, 3, 4. ; 2. Znane, Nieznane, Zapomniane, t. 1, 2, 3, 4. ; 3. Różne Odsłony Kobiecych Światów – cykl publikacji pokonferencyjnych ukazujących się od 2012 r. Badania naukowe obejmują zarówno odsłony kobiecych światów – np. lęki, samotność, starość, tożsamość, działalność i twórczość w Polsce i za granicą, jak i kobiece doświadczanie i porządkowanie świata w kulturze ludowej, tradycyjnej i jej literackich ilustracjach.
Felicja Stendigowa (1895–1945). Sylwetka publicystki dwutygodnika „Moja Przyjaciółka” ze Żnina
Authors:   Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Wodniak Katarzyna
Published: July 2023

W latach 1934–1939 w Zakładach Wydawniczych Alfreda Krzyckiego w Żninie (Wielkopolska) ukazywał się ilustrowany dwutygodnik kobiecy „Moja Przyjaciółka”, pierwszy periodyk kobiecy, który (w listopadzie 1937 r.) przekroczył próg 100 tys. egzemplarzy jednorazowego wydania, należący do tytułów prasowych o najwyższych w Polsce nakładach. Wielotematyczny i przystępnie redagowany poradnik dla możliwie szerokiego audytorium kobiecego miał własne grono zamiejscowych współpracowniczek, bliżej nieznanych czytelniczkom elitarnych magazynów dla wykształconych mieszkanek wielkich miast. Należała do nich Felicja Stendigowa (1895–1945), której ściślejsze związki z „Moją Przyjaciółką” datowały się od wiosny 1936 r. Dziennikarka i eseistka rodem z Krakowa, poliglotka władająca kilkoma językami, prawnuczka wielkiego rabina Akiwy Eigera i siostra światowej sławy matematyka i fizyka Leopolda Infelda w jednej osobie, publikowała w wielu tytułach prasowych, nie tylko kobiecych – warszawskiej „Pani Domu”, tygodniku „AS” i „Kurierze Kobiecym” krakowskiego koncernu IKC, „Nowym Dzienniku”. Jej teksty znaleźć można ponadto w kwartalniku poświęconym zagadnieniom reformy seksualnej i obyczajowej „Życie Świadome” wychodzącym w Krakowie, do którego współpracowników zaliczali się Tadeusz Boy-Żeleński i Irena Krzywicka. Związki Felicji Stendigowej z wydawanym w stolicy Pałuk masowym dwutygodnikiem kobiecym nie były dotąd podnoszone, choć ona sama zaczyna powoli wkraczać w orbitę zainteresowań badaczy.
Zjazdy Ligi Kobiet na łamach „Trybuny Ludu”
Authors:   Uniwersytet w Białymstoku, Bauchrowicz-Tocka Maria
Published: July 2023

Liga Kobiet była największą organizacją kobiecą w Polsce Ludowej. W okresie jej działalności (lata 1945–1989) zostało zorganizowanych 9 zjazdów (wśród nich pierwszy w 1951 r., nazwany kongresem, i jeden nadzwyczajny w 1981 r., tuż przed ogłoszeniem stanu wojennego). Zjazdy Ligi oceniały minione kadencje oraz podejmowały uchwały wyznaczające kierunki dalszej działalności. Celem artykułu jest zbadanie, w jakim zakresie zjazdowa tematyka interesowała „Trybunę Ludu” – główny organ prasowy KC PZPR, jaki był medialny przekaz zjazdowych obrad Ligi, które z zagadnień były szczególnie eksponowane, jaki obraz organizacji wyłaniał się z prasowych relacji i trafiał do czytelników.
Донецьк як гетеротопiя в сучаснiй украïнськiй мiлiтарнiй прозi
Authors:   Днiпровський нацiональний унiверситет iменi Олеся Гончара, Факультет украïнськоï й iноземноï фiлологiï та мистецтвознавства, Кафедра украïнськоï лiтератури, Кропивко Iрина
Published: July 2023

Modern Ukrainian prose reflects the realities of Russo-Ukrainian war that has been in progress for over eight years. One of the aspects is the life of average citizens in the occupied territories. Donetsk used to be a well-off Ukrainian metropolis. Today, it is the capital of an unrecognized republic, the territory of anarchy. The article leans on Baby Daughter by Tamara Duda (alias Seed of a Walnut) and Long Hours by Volodymyr Rafieienko to outline the specificity of representing Donetsk as heterotopia at conceptual, discourse and chronotope levels, as well as at the level of separate ways to narrativise the artistic world of the story.
Apokalipsa po rosyjsku (Dmitrij Głuchowski, Outpost)
Authors:   UAM Poznań, Instytut Filologii Rosyjskiej i Ukraińskiej, Zywert Aleksandra
Published: July 2023

The subject of the analysis is the novel Outpost and Outpost 2 by Dmitry Glukhovsky. In this work, the author draws on post-apocalyptic roots and outlines a vision of Russia after the catastrophe – the civil war, which made Russia only formally exist as a state. Unlike the classic post-apocalyptic works in which we already observe a solidified “new world”, Glukhovsky focuses on the process of its creation – an element omitted in “mature” post-apocalyptic literature – mainly from the sociological point of view. The emphasis on the social aspect in combination with the political dimension makes the novel go beyond the scope of popular literature. It is also a painful, dystopian reflection on the projected future of Russia – a country which, according to the author, has not managed to break out of the vicious circle of utopian mania for greatness.
Resumen y materiales para la presentación del Sr. Tarik Yahya, alcalde de Nador
Authors: Yahya Tarik
Published: July 2023

Materiales y anexos
Synthesis and characterization of grafted cellulose for use in water and metal ions sorption
Authors: Nada Abd-Alla M. A. , Alkady Mohamed Y. , Fekry Hesham M.
Published: July 2023

Graft copolymerization of acrylamide monomer onto cellulose, using ceric ammonium nitrate as initiator, was investigated. Water and metal ions sorption by this grafted cellulose were estimated. The conditions of grafting, e.g. grafting time, dose of initiator, ratio of monomer to cellulose, acid concentration and liquor ratio, were evaluated. The different properties as graft and graft efficiency percentage, as well as polymerization percent, have been determined. Grafted cellulose has been characterized by FTIR and swelling studies. Sorption of different metal ions in the mixture, e.g. Cu, Cr, Ni, and Pb, by grafted cellulose was investigated. The effect of hydrolysis of grafted cellulose by using sodium hydroxide on its swelling properties and metal ions sorption was also investigated. Hydrolysis increases the sorption affinity of grafted cellulose toward water and metal ions.
Application of Microcrystalline Cellulose Powders Obtained from Gossypiumherbaceum As Dry Binder in the Formulation of Diazepam Tablets
Authors:   Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Port Harcourt - 500004, Nigeria, Nwachukwu Nkemakolam , Ofoefule SabinusIfeanyi ,   Drug Delivery and Nanotechnology Unit, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka - 410001, Nigeria
Published: July 2023

Background: Microcrystalline cellulose (MCC) is a popular dry binder in tablet formulation. Differences in its processing methods can significantly affect its tableting properties. Aim: Assessment of the tableting and in-vitro release properties of diazepam tablets formulated with Gossypiumherbaceum (GH) derived MCC that was dried by two different methods. Methods: G.herbaceum bolls were de-lignified in sodium hydroxide solutions to obtain α-cellulose which was hydrolyzed with 2.0 N hydrochloric acid to obtain MCC. The neutralized damp MCC was separated into two portions. One portion was fluid bed dried (MCC-GossF) while the other portion was lyophilized (MCC-GossL). Diazepam tablets were prepared with 20, 30 and 40%w/w of MCC-GossF and MCC-GossL..Avicel PH 102 (AVH-102) served as comparing standard. The formulations were evaluated using standard methods. Results: The powders flowed well and the tablets met with British Pharmacopoiea specifications. Diazepam tablets containing MCC-GossL (DGL) were stronger than those of MCC-GossF (DCF) (p<0.05). The disintegration times were < 2 min and friability ≤ 1%. The strength of tablets containing AVH-102 (DAV) compared well with those of DGL tablets. More than 80% of diazepam was released from the tablets. Conclusion: The GH MCCs served as good dry binders in the formulation of diazepam tablets.
FOREWORD
Authors: An Nguyen Tac
Published: July 2023

FOREWORD
SOME KINDS OF COASTAL AND SEA SPACE RESOURCES IN VIETNAM
Authors: Thanh Tran Duc
Published: July 2023

Recently, the space resources have been reported in the management documents; however, there have been not researches on the scientific basis for definition of these resources, yet. For the first time, this paper mentioned the sea space resources in Vietnam, and could be regarded as a first step for the further discussions. Referencing international literatures and starting from realistic awareness, it is realizes that the marine resources in Vietnam composes of living, non – living and sea space. The sea space resources could be defined as the benefits from an area or a site on sea, or in coastal zone, and situated in the spatial relations of this area or site. The sea space resources includes living and non living components, however, their key benefits must be get from values of sea/land forms and their spatial situations. The principal space resources in Vietnam Sea can be determined such as systems of water bodies or geosystems under the state sovereignty. They are included the coastal areas, islands, coastal bodies of water, offshore waters with the components of land (or bottom), water and air. This paper presented some concrete kinds of sea space resources included estuary, lagoon, coastal bay and island with the general estimation on developmental potentials.
STUDY ON THE CHANGE OF THE INTERNAL WAVE AMPLITUDES IN A DISPLACEMENT PROCESS IN THE VIETNAMESE WATERS
Authors: Xuan Nguyen Ba , Chung Tran Van
Published: July 2023

In  this paper some results  of calculating  and predicting a displacement of the  internal  wave  amplitudes  on  basis  of using the  method of solving  the  equations  of the Eigenvalues and Modes of the internal wave are presented.  The results show that:  the internal waves  always  displace  in  space and time  with  the amplitudes  changed.fi-om  I m to  35m.  The internal waves in  the study region have a tendency of increasing the average amplitudes with the depth and reach the maximum values in the layers of 250m, 350m and 450m.