bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence Rates of Malignant Neoplasms of Female Genital Organs in the Cohort of Females Occupationally Exposed to Ionizing Radiation
Authors:   Southern Urals Biophysics Institute, Ozyorsk, Russia, Rumyantseva A.V. , Azizova T.V. ,   Southern Urals Biophysics Institute, Ozyorsk, Russia, Bannikova M.V. ,   Southern Urals Biophysics Institute, Ozyorsk, Russia
Published: May 2023

Purpose: To assess the association of incidence rates of malignant neoplasms of female genital organs (MNs of FGO) in women who were chronically occupationally exposed to ionizing radiation (IR) with radiation and non-radiation factors. Material and methods: To perform the study, the cohort of females employed at the Mayak PA during 1948–1982 and followed up until 31 December 2018 was considered. All members of the considered cohort were chronically exposed to IR. Results: 83.6 % of females were first diagnosed with a MN of FGO at age after 50 years. More than 50 % of MNs of FGO were reported during 1991–2010. Standardized rates of MNs FGO varied with the calendar period with the highest rates observed during 1996–2005. The analysis of the variation of the standardized rates with time demonstrated a significant tendency to increase by the end of the follow-up (R²=0.67, p=0.03). The incidence rates of MNs of FGO on average increased annually by 1.0 % (95 % CI 0.3–1.6). The standardized rates of MNs of FGO were significantly higher in females who had been diagnosed with endometriosis prior to MNs of FGO. The standardized rates of MNs of FGO were significantly higher in females externally exposed to gamma-rays at uterus absorbed dose of 0.2–0.5 Gy and above 0.5 Gy compared to females who had been exposed at lower doses. MNs of the uterine body were the most common among total MNs of FGO. More than 90 % of MNs of the uterine body were registered during menopause. The standardized rate of MNs of the uterine body in females of the study cohort was 0.37 ± 0.05. The decrease in the standardized rate of the MNs of the uterine body was observed in 1986–1995 calendar period. The spline regression analysis of the variation of the standardized rate of MNs of the uterine body demonstrated the annual increment by 0.9 % (95 % CI 0.7–2.5) on average. The analysis demonstrated a tendency of the standardized rate of MNs of the uterine body to increase in the study cohort of females (R²=0.46, p=0.16). The standardized rates of MNs of the uterine body were significantly higher in females who had been diagnosed with endometriosis prior to MNs of the uterine body. Standardized rates of MNs of the uterine body were significantly higher in females externally exposed to gamma rays at the cumulative uterus absorbed dose above 0.5 Gy compared to females exposed at lower doses. Conclusion: MNs of FGO were associated with both known non-radiation factors (age, calendar period, endometriosis) and the cumulative uterus absorbed dose from chronic occupational exposure to ionizing radiation.
Radiation Therapy for Breast Cancer pT1–3N0–1M0 after Mastectomy or Subcutaneous/Skin-Preserving Mastectomy with Reconstruction. Literature Review
Authors:   P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russia, Rasskazova E. , Zikiryakhodzhaev A. ,   P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russia,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia,   Peoples’ Friendship University of Russia, (RUDN University), Moscow, Russia, Khmelevsky E. ,   P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russia
Published: May 2023

Purpose: The literature review analyzes publications over the past decades on the need for radiation therapy after mastectomy or subcutaneous/skin-preserving mastectomy with reconstruction. Results: Risk factors for breast cancer recurrence were analyzed. The effect of radiation therapy on the recurrence of breast cancer after mastectomy, subcutaneous and skin-preserving mastectomy with reconstruction was evaluated depending on the stage, lymph node lesions, and the presence of unfavorable molecular biological types. Indications for radiation therapy are described. The effect of radiation therapy on early and late complications of the reconstructed breast and options for reducing the percentage of complications were analyzed. Conclusion: The exclusion of radiation therapy from the breast cancer treatment plan is a decrease in the percentage of complications caused by radiation therapy, for example, during implant reconstruction – a decrease in capsular contractures. And, as a result, improving the quality of life of patients, reducing repeated operations in case of complications, which means it is economically profitable. In recent years, due to the increasing need for various breast reconstruction options, the surgeon and radiotherapist have faced the task of choosing the optimal sequence of breast reconstruction, as well as reducing the risk of post-radiation complications. Radiation therapy, along with reducing the risk of relapse of the disease, increases the risk of complications after breast reconstruction, and vice versa, the reconstructed mammary gland can cause difficulties for the radiologist to correctly deliver the required dose of radiation. Minimizing the frequency and severity of complications after radiation therapy on the reconstructed gland without compromising oncological or cosmetic results is an important and common interdisciplinary goal for oncologists and radiotherapists.
The Efficacy of Radionuclide Therapy for Bone Metastasis
Authors:   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Krylov A.S. , Narkevich B.Ya. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Association of Medical Physicists of Russia, Moscow, Russia, Ryzhkov A.D. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Krylov V.V. ,   A.F. Tsyb Medical Radiology Research Center, Obninsk, Russia, Geliashvili T.M. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Pronin A.I. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
Published: May 2023

Purpose: Development of a methodology for evaluating the effectiveness of radionuclide therapy for bone metastases based on dosimetric and clinical and laboratory criteria. Material and methods: A comparative analysis of the functionality of various criteria for assessing the long-term and short-term effectiveness of radionuclide therapy of bone metastases was carried out. Focal absorbed doses of internal exposure are considered as one of the criteria, for the determination of which a simplified method for their calculation is proposed based on quantitative data from SPECT/CT scanning of an X-ray phantom and a real patient who has been injected with a β-γ-emitting therapeutic radiopharmaceutical. Results: On a clinical example of radionuclide therapy with 177Lu-PSMA-617 in a patient with stage 4 prostate cancer, dose estimates of internal irradiation of foci with β-particles were obtained. Calculations were made for bone metastases of 7 localizations in dynamics for each of the 5 fractions of the course of radionuclide therapy. It is shown that the total focal doses for 5 fractions of internal exposure vary from 70.6 to 116.8 Gy for different foci, which corresponds to the literature data obtained by more accurate methods of dosimetry of internal exposure. The obtained dosimetric data were compared with efficacy estimates based on metabolic, hematological, hormonal and biochemical parameters, as well as on the tumor marker PSA. Conclusion: The main criterion for assessing the antitumor efficacy of radionuclide therapy is the metabolic activity of bone foci, while data on the accumulated focal doses of internal β-irradiation are of an auxiliary nature. Hematological indicators should be the criteria for assessing radiotoxicity and used to adjust the course of radionuclide therapy.
Development of Methodological Documents Regulating the Clinical Trials of New Radiopharmaceutical Drugs
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Labushkina A.A. , Klement’eva O.E. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Kodina G.E. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Samoilov A.S. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: May 2023

Introduction The forms of radiopharmaceutical drugs clinical trial protocols The forms of the researcher’s brochure for clinical studies of radiopharmaceutical drugs The forms of reports on the results of clinical trials for radiopharmaceutical drugs Conclusion
Nuclear Workers – on the Question of Unification of Russian-Language Terminology (Brief Report)
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Koterov A.N. , Ushenkova L.N. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Wainson A.A. ,   N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Published: May 2023

The issue of terminology is considered when searching for sources for analytical and synthetic studies of effects among workers in the nuclear industry (nuclear fuel cycle for the production of nuclear weapons components and fuel for power or transport installations). It is noted that if there are relatively few English-language names of this professional group (only four were found) with the absolute prevalence of the term ‘nuclear workers’, then for Russian-language sources there is a wide variety of names (various combinations with ‘atomic’ and ‘nuclear’ ‘industry’ or ‘industry’ etc.) without a hint of specificity. It is concluded that in the Russian-language literature it is most appropriate to use the term ‘workers in the nuclear industry’ [=nuclear workers], given that the name ‘nuclear industry’ is official.
Influence of organic and inorganic nitrogen on the growth and yield of irrigated rice
Authors: Sarker Uttam Kumer , Uddin Md Romij , Sarkar Md Abdur Rahman , Salam Md Abdus , Hasan Ahmed Khairul
Published: May 2023

The objective of this research was to evaluate the impact of organic and inorganic sources of nitrogen (N) on growth dynamics, yield, N content, N uptake and agronomic efficiency (AE) of irrigated rice. Four  high-yielding boro (dry season irrigated) rice cultivars viz. BRRI dhan29, BRRI dhan59 Binadhan-8 and Binadhan-10 along with six N management combinations viz. Control (no N application), 140 kg N ha-1 from Prilled Urea (PU), 83 kg N ha-1 from Urea Super Granule (USG), 105 kg N ha-1 from PU + 3 t ha-1 Poultry manure, 112 kg N ha-1 from PU + 5 t ha-1 Cowdung and  77 kg N ha-1 from PU + 4 t ha-1 vermi compost were used in the study. The cultivar Binadhan-8 had a higher yield than all other cultivars because of the highest total dry matter (TDM), number of effective tillers hill-1, and number of grains panicle-1.Growth, TDM, yield, and AE were highest with 105 kg N ha-1 from PU + 3 t ha-1 Poultry manure application .The highest N uptake in grain and straw (120.1 kg ha-1 and 96.14 kg ha-1, respectively) was shown by rice cultivar Binadhan-8. In addition, significant relationships between N concentration and growth dynamics, TDM, N content, N uptake, and yield were observed. These results indicated that cultivars with the capacity to uptake more N can produce more yield and N application along with poultry manure could enhance growth, yield, AE. Therefore, the combined application of N sources in the form of PU + Poultry manure can produce good performances in terms of growth and yield of HYV rice under irrigated condition.

Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 9-23
Labour Analgesia in a Patient with Dengue Fever - Case Report
Authors: Khandoker MR , Banu L A
Published: May 2023

Abstract not available. 
JBSA 2018; 31(1): 48-49
Analytical Solution of Telegraph Equations by Variational Iteration Method
Authors: Aisha Awais
Published: May 2023

In this paper, the variational iteration method (VIM) is utilized for the solution of telegraph equations, which emerge in the propagation of electrical signals along a broadcast line. The suggested method is progressively effective and simpler to deal with as contrast with the decomposition method. Numerical outcomes demonstrate the effectiveness and exactness of the proposed VIM.
Magda A. Kövesi A permi nyelvek ösi képzöi
Authors: Stipa G. J.
Published: May 2023

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Zur deutschen Kalevala-Ausgabe von 1852
Authors: Schiefer Erhard
Published: May 2023

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ANALISIS TINGKAT KEPUASAN PESERTA DIDIK DALAM MENGGUNAKAN E-LEARNING DI SEKOLAH DASAR
Authors: Purmadi Ary , Garnika Eneng
Published: May 2023

Services in both academic and non-academic very important in achieving learning objectives. The availability of learning facilities consisting of e-learning can be a learning resource that can be used by students in learning. This study aims to analyze the level of participant satisfaction in using e-learning at the elementary school level. The method used is a quantitative method using a questionnaire to respondents. While the learning management system (LMS) used is Edmodo. The sample used was class VI as many as 31 students in SDN 3 Dasan Lekong. The results of the study were as many as 5 people or 16% were very satisfied, 23 people or 74% were satisfied, and 3 people or 10% less satisfied were quite satisfied in using e-learning. While there were no students who stated they were not satisfied in using e-learning. Student satisfaction is a form of desires, hopes and needs of students can be met. This is intended as the desires and expectations of students about the use of e-learning obtained from students' responses have been good.
Нормирование огнестойкости современных строительных конструкций из железобетона
Authors: Полевода Иван Иванович , Жамойдик Сергей Михайлович , Зайнудинова Наталья Владимировна , Нехань Денис Сергеевич
Published: May 2023

Цель. На основании разработанной комплексной методики расчета пределов огнестойкости современных строительных конструкций из железобетона получить табличные данные по оценке огнестойкости железобетонных стен, колонн, балок и плит, учитывающие наличие воздушной полости, класс бетона, вид заполнителя, предварительное напряжение арматуры, а также наличие конструктивной огнезащиты на основе огнестойких гипсовых плит и огнестойких подвесных потолков.
Методы. Анализ и обобщение результатов расчета пределов огнестойкости железобетонных строительных конструкций по разработанной на основе экспериментальных (лабораторные и огневые, в том числе натурные) и теоретических исследований методике.
Результаты. Разработаны правила определения пределов огнестойкости современных строительных конструкций из железобетона, основанные на упрощенном использовании табличных данных, которые позволяют обеспечить пожарную безопасность зданий и сооружений путем оценки предела огнестойкости незащищенных железобетонных строительных конструкций и подбора параметров конструктивной огнезащиты для его повышения.
Область применения исследований. Полученные результаты могут применяться при разработке норм проектирования и конструирования железобетонных конструкций, для решения задач по оценке огнестойкости строительных конструкций и элементов при проектировании и строительстве зданий и сооружений, в том числе в рамках действующих норм.
Türkiye`de Profesyonel 400m Koşucularının Müsabaka Ortamında Koşu Parametrelerinin Değerlendirilmesi
Authors: Siahjani Shahriar , Akşit Tolga , Erman Berkant
Published: May 2023

Performanstaki küçük farklılıklar kısa mesafe koşu branşlarında sonucu önemli derecede etkilediğinden, enerji kaynaklarını ekonomik kullanmanın en iyi yolu ile ilgili bilgiler oldukça ilgi çekicidir. Bununla birlikte, performans üzerine literatüre bakıldığında, bu konuda az sayıda çalışma bulunduğu görülmüştür. Bu çalışmada, atletizm branşından 400 m koşu parametrelerinin ve sporcuların açısal kinematikleri yönünden incelemesi amaçlanmıştır. Sporcu verilerini elde etmek için müsabaka ortamında dört kamera uygun yerlere yerleştirilmiş ve çekim yapılmıştır. Müsabakanın iki bölgeden oluşan en hızlı ve en yavaş bölgelerine göre (140/150 m) ve (350/360 m) koşu mekaniği olarak en anlamlı farklılıklar, adım uzunluğu (AU) (p<0,001) ve adım sıklığı (AS) (p=0,002) olduğu tespit edilmiştir. İlk 100 m de AS, ikinci 100 m AU, üçüncü 100 m de AS baskın olduğu tespit edildi. Son 100 m de iki parametrede nerdeyse paralel olarak bir düşüş görüldü Üçüncü 100 m de koşu hızının azalması, AU parametresinin anlamlı olarak kısalması ile açıklanabilir (p<0,001). Tüm açısal kinematik verilerin negatif değişimleri sporcuların koşu parametrelerin negatif değişimleri ile paralel olduğu tartışma konusu olmuştur. Atletlerdeki en belirgin değişim gösteren açılar, Dorsifleksiyon (DF) pozisyonunda diz açısı (β°), bilek açısı (ι°), gövde açısı (α°) ve Plantarfleksiyon (PF) pozisyonunda diz açısı (β°) olduğu tespit edildi. Bu kinematik değişimlerin yarışmanın son metrelerinde yavaşlamanın sebeplerinden biri olduğu ve atletlerin AS ve AU koşu parametrelerin doğrudan etkilediği düşünülmektedir. Sonuç olarak yarışmanın en hızlı ve en yavaş bölümündeki tüm parametrelerde bir düşüş ve açısal kinematik verilerinde 8 faktörden 7’si istatistik olarak anlamlı fark göstermektedir.
Connectivity in juvenile yellowfin tuna Thunnus albacares between temperate and tropical regions of the western Pacific Ocean
Authors: Satoh K , Katayama S , Tanabe T , Okamoto K
Published: May 2023

Yellowfin tuna Thunnus albacares is a commercially important fish species widely distributed between 40° S and 40° N. Mixing rates between tropical and temperate areas of the western Pacific Ocean were investigated using stable carbon (δ13Cotolith) and oxygen isotopes (δ18Ootolith) in whole otoliths of small juveniles (mean: 5.8 cm standard length, SL) and in otolith cores of large juveniles (32.4 cm SL). The density distribution of δ18Ootolith values for small juveniles showed a significant difference between the areas, whereas patterns for large juveniles were almost identical between areas. In addition, modal values for large juveniles spanned several small juvenile modes. The density distribution of δ13Cotolith values for small juveniles had a single significantly different mode for each area, whereas the distribution of δ13Cotolith values for large juveniles in these areas was bimodal, particularly in the temperate area; these modes corresponded to those for small juveniles in each area. These modal patterns indicate that the majority of large juveniles captured in the temperate area have tropical origins, and mixing from tropical to temperate areas occurs between the areas before recruitment to fisheries in each area. These connectivity patterns during early life history can contribute to refinement of stock assessments of this commercially valuable species.
Sociálna opora ako významná súčasť života adolescenta
Authors:   Univerzita Pavla Jozefa Šafárika v Košiciach, Hovanová Magdaléna
Published: May 2023

Monografia sa venuje sociálnej opore, zasadenej do prostredia adolescenta. Sociálnu oporu možno označiť aj ako vzťahovú oporu od prostredia, v ktorom jedinec žije a tým sa zvyšuje jeho odolnosť voči stresu a chuť zdolať aj životné neúspechy a krízy. Práve z tohto dôvodu bola sociálna opora vymedzená aj v súvislosti sociálno-ekologickej teórie. Inováciou vo vzťahu so sociálnou oporou bola teória „Push-pull“, orientujúca sa na motiváciu jedinca. Definičné ukotvenie sociálnej opory bolo postavené na jej najznámejších teóriách. Najväčšia pozornosť bola však zameraná na možnosti merania sociálnej opory, pretože jej viacdimenziové meranie je nevyhnutné pre určenie mechanizmu, akým funguje. Monografia preto ponúkla autorské validizačné spracovanie a overovanie psychometrických vlastností dvoch samostatných metodík Multidimensional Scale of Perceived Social Support (MSPSS) - (Zimet, Dahlem, Zimet, Farley 1988) a Social Support Survey (MOS) – (Sherbourne, Stewart 1991). Výsledkom monografie sú dve validizačne overené samostatné metodiky pre meranie druhov a zdrojov sociálnej opory, ktoré sú spoľahlivé pre používanie v skupine slovenských adolescentov (MOS-SK a MSPSS-SK).
Heart rate and increased intravascular volume.
Authors: Souček M , Kára T , Jurák P , Halámek J , Špinarová L , Meluzím J , Toman J , Řiháček I , Šumbera J , Fráňa P
Published: May 2023

The objective was to establish whether an intravascular volume increase leads to a heart rate (HR) increase without increased sympathetic tonus. HR changes at rest and at deep breathing (6/min - simulated increase of atrial filling pressure) were measured in patients after heart transplantation. Evaluation of dependency of HR changes on breathing depth was done through a new time series methodology. The data was evaluated through graphs displaying a significant increase in the graph area at deep breathing, when compared with breathing at rest (p<0.01). We presume that an increase in HR corresponds to increased intravascular volume and malfunctioning kidneys.
Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels.
Authors: Rosická M , Kršek M , Matoulek M , Jarkovská Z , Marek J , Justová V , Lacinová Z
Published: May 2023

Ghrelin is a new endogenous ligand for the growth hormone secretagogue receptor. It activates the release of growth hormone from the pituitary and it also participates in the regulation of energy homeostasis. The aim of the study was to characterize changes in serum ghrelin levels in obese subjects and their relationship to the serum levels of leptin and soluble leptin receptor. Eight obese patients (6 women and 2 men) with body mass index (BMI) 40.3+/-13.4 kg.m(-2) and eight healthy controls (5 women and 3 men) with BMI 22.7+/-1.3 kg.m(-2) were examined. The ghrelin serum levels (165.0+/-58.1 vs. 343.37+/-81.96; p<0.001) and soluble leptin receptor serum levels (7.25+/-3.44 vs. 21.80+/-4.99; p<0.0001) were significantly lower in obese patients. The leptin serum levels (23.45+/-12.90 vs. 6.41+/-2.96; p<0.005) were significantly higher compared to the lean subject group. In both measured groups the levels of serum leptin significantly positively correlated with BMI. We proved a significantly lower serum ghrelin levels in the group of obese patients in comparison with the control group.
IgA and IgG antigliadin, IgA anti-tissue transglutaminase and antiendomysial antibodies in patients with autoimmune thyroid diseases and their relationship to thyroidal replacement therapy.
Authors: Jiskra J , Límanová Z , Vaníčková Z , Kocna P
Published: May 2023

Celiac disease is a chronic illness of the small bowel caused by gliadin intolerance in genetically predisposed subjects. The aim of this study was to investigate serum levels of IgA and IgG antigliadin antibodies, IgA antiendomysial antibodies, and IgA anti-tissue transglutaminase antibodies in 169 patients with autoimmune thyroid diseases, i.e. chronic thyroiditis and Graves' disease. Antiendomysial antibodies were positive in 2 out of 169 persons (1.18%), IgA antigliadin antibodies in 15.98%, IgG antigliadin antibodies in 51.48%, and IgA anti-tissue transglutaminase in 14.79%. The prevalence of positivity was higher compared to the 1312 control blood donors described in our previous study (Vancíková et al. 2002) (p<0.05). Patients with chronic thyroiditis treated with a high replacement dosage of levothyroxin (125-200 microg daily) had higher serum levels of IgA antigliadin antibodies in comparison with patients treated with a lower dosage (50-100 microg daily) (medians: 13.00 vs. 19.69, p=0.033). We found a negative correlation of IgA anti-tissue transglutaminase antibodies and total calcium serum levels (r = -0.480, p=0.0236, n=22). We can conclude that in persons with autoimmune thyropathy there is a high prevalence of positive antigliadin, anti-tissue transglutaminase and antiendomysial antibodies. Latent celiac disease may lead to impaired resorption of therapeutically administered levothyroxine, calcium, or other substances.
A RenBikeTour története és tapasztalatai
Authors: Schneider Károly
Published: May 2023

A veseelégtelen betegek részére szervezett, világviszonylatban is különlegességnek számító, nagy sikerű országos RenBikeTour kerékpárosprogram 2013-ban indult útjára, amelyben a Covid-pandémia okozott csak megtorpanást. Sikerének kulcsa az a légkör, amelyben a vesebetegek biztonságban érezhetik magukat a túra során, ahol találkozhatnak sorstársaikkal, megoszthatják egymással betegségükből és a művesekezelésből adódó tapasztalataikat, ahol találkozhatnak transzplantált betegtársakkal, akiktől személyes beszélgetések során első kézből nyerhetnek információt a veseátültetésről, az ezzel együtt járó nehézségekről és dialízishez képest megváltozó életminőségről, ahol a családtagok, barátok és szimpatizánsok, valamint segítő egészségügyi dolgozók között ” egészségesnek” érezhetik magukat, ahol új barátokra lelnek, ahol kontrollált körülmények közt kapcsolódhatnak ki, mindezt támogatók segítségével ingyenesen.
L’analogia in matematica: convinzioni e competenze in una classe di seconda media
Authors: Bordogna Giada
Published: May 2023

L’articolo presenta il percorso didattico svolto in una classe di seconda media con lo scopo di indagare lo sviluppo delle convinzioni e delle competenze degli allievi riguardo l’utilizzo dell’analogia nella risoluzione dei problemi di matematica. Dopo aver raccolto le convinzioni iniziali degli allievi è stato sviluppato un itinerario composto da molteplici attività finalizzato ad approfondire e rafforzare la consapevolezza degli allievi rispetto alle diverse tipologie di analogia e al loro utilizzo per facilitare la risoluzione di problemi. I risultati ottenuti mostrano come la consapevolezza degli allievi sulle diverse tipologie di analogie e sulla loro utilità sia migliorata. In particolare, essi riconoscono che saper individuare due problemi analoghi rispetto al procedimento facilita la risoluzione di situazioni nuove. Al termine del percorso si riscontra anche che la capacità di una parte degli allievi di applicare il pensiero analogico nella risoluzione dei problemi è aumentata, favorendo così l’attività di transfer di conoscenze.
Educare alla “matematizzazione e modellizzazione” attraverso l’uso delle rappresentazioni semiotiche nella scuola media
Authors: Nestola Maria Giuseppina Chiara
Published: May 2023

L’articolo descrive un’esperienza didattica svolta in una classe di quarta media attitudinale1 con lo scopo di indagare le convinzioni e le competenze degli allievi in merito all’uso delle rappresentazioni semiotiche nella comprensione e risoluzione di una situazione matematica. Il percorso didattico si compone di molteplici attività volte a stimolare l’uso di differenti registri semiotici (linguistico, numerico, algebrico e grafico) nell’attività di risoluzione di un problema. Gli allievi hanno partecipato con motivazione e interesse alle varie attività, apprezzando i relativi riferimenti al mondo reale. I risultati mostrano come accompagnare l’allievo a matematizzare situazioni attraverso la gestione di differenti rappresentazioni dello stesso oggetto matematico favorisca una comprensione più profonda del problema e un utilizzo più consapevole degli strumenti matematici necessari per la sua risoluzione.
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1 In Canton Ticino a partire dalla terza media gli allievi vengono inseriti in corsi base e attitudinale in funzione delle competenze matematiche raggiunte alla fine della seconda.
Propostas inovadoras frente aos desafios da gestão democrática: uma análise da realidade educativa nas escolas do município de Paranavaí-PR
Authors: Rohling Beatriz Longen , Silva Luciana Moraes
Published: May 2023

Essa pesquisa objetivou ressaltar as contribuições da gestão democrática para a construção de uma educação de qualidade, destacando a necessidade de uma postura inovadora do gestor frente aos desafios atuais para sua implementação. Trata-se de uma pesquisa exploratória, de abordagem quali-quantitativa, com método desenvolvido mediante o uso de ferramentas de estudos documentais, bibliográficos e questionário semiestruturado aplicado aos gestores selecionados entre as dezenove escolas públicas e cinco privadas do município de Paranavaí-PR. Na análise dos dados coletados, as gestoras apresentaram como desafio principal a falta de participação da comunidade. Destacaram também, como perfil de uma gestão inovadora, um cargo dinâmico, com bom senso, boa comunicação, ter comprometimento, ser humanista e ir além do tradicional, trazendo a tecnologia como ferramenta auxiliadora desse processo, acrescentando qualidade à educação. Além disso, constatou-se que a gestão democrática é confundida com outros modelos de gestão e, sabe-se que essa só é efetivada com a participação de todos membros da instituição. A pesquisa, portanto, permitiu entender que gerir democraticamente tem sido um grande desafio, tendo em vista o não envolvimento de alguns agentes na construção do seu processo e que buscar inovar frente a esses percalços envolve mudanças de postura e estratégias para tornar o espaço escolar significativo.
O luto em Hilda Hilst: narrativas de derrelição em A Obscena Senhora D
Authors: Grigoleto Netto Jose Valdeci , Barros Filho Mario Thadeu Leme de
Published: May 2023

O luto é uma resposta natural que acontece após a ruptura de um vínculo afetivo e que, apesar de ser uma experiência universal, espera-se que cada pessoa experiencie seu luto de forma particular e subjetiva. Com o intuito de apresentar e discutir acerca da temática do luto, nesta pesquisa utilizou-se como objeto de análise uma obra literária da autora brasileira Hilda Hilst intitulada A Obscena Senhora D, publicada originalmente em 1982. Para tanto, à priori, foi realizada uma apresentação acerca de vida e obra da autora para, na sequência, realizar uma apresentação da obra escolhida. Na sequência, foi construída uma apresentação teórica em referências que discutam e apresentem a temática da ruptura de vínculos, com foco para discussões acerca do luto nas relações conjugais. Por fim, com a análise e leitura realizada, constatou-se o quanto a obra dialoga com as teorias do luto, em especial quando se apresenta os recursos de enfrentamento e de adaptação frente às perdas.
Job profiles for museums in the digital era: research conducted in Portugal, Italy and Greece within the Mu.SA project
Authors: Silvaggi Antonia , Pesce Federica
Published: May 2023

Due to the increasing use of technologies in the museum sector, new job profiles are now emerging within that sector. This paper describes the key findings of the research activities carried out in Greece, Portugal and Italy within the Mu.SA – Museum Sector Alliance – project funded by the European Erasmus Plus Programme – Sector Skills Alliances. Our research addressed the questions of what skills and know-how are needed by museum professionals in the process of digital transformation of their sector and what emerging job profiles would help museums to thrive in the digital environment. The research validated four job profiles such as Digital Strategy Manager, Digital Collections Curator, Digital Interactive Experience Developer and Online Community Manager. It also showed that there are some digital and transferable competences common to the four museum job profiles, but, most importantly, that an awareness of digital culture should be developed throughout the whole of a museum's workforce.
Forgotten legacy: an endeavor to highlight heritage food of Egyptian Bedouins
Authors: Abdulmawla Mostafa , Imperiale Francesca , Abd El-Wahab Morsy Mohamed , Saad Hesham Ezzat , Qoura Omar
Published: May 2023

Despite the issue of food heritage having an important debate around the globe, there is still inconclusive literature addressing Egyptian heritage food in general, and particularly the gastronomic heritage of Egyptian Bedouins. The main argument of the current study is firstly to identify a set of genuine heritage foods of Egyptian Bedouins by using explicit criteria. Then, transfer the data to develop a documented recipe book for these meals, which is intended to be an initial phase of promoting them as a unique component of the Egyptian cultural legacy. The target population of the study is the Egyptian Bedouin society, both in the western and eastern deserts. Through a qualitative approach, 15 semi-structured interviews with elderly local people were undertaken before conducting a focus group with six Bedouin experts. The findings section reported eight heritage foods of Egyptian Bedouins and produced a recipe book for them.
The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms
Authors: Yi You , Zhong Chen , Wei-wei Hu
Published: May 2023

Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. FSs are one of the commonest presentations in young children, occurring in up to 4% of children between the ages of about 6 months and 5 years old. FSs not only endanger children’s health, cause panic and anxiety to families, but also have many adverse consequences. Both clinical and animal studies show that FSs have detrimental effects on neurodevelopment, that cause attention deficit hyperactivity disorder (ADHD), increased susceptibility to epilepsy, hippocampal sclerosis and cognitive decline during adulthood. However, the mechanisms of FSs in developmental abnormalities and disease occurrence during adulthood have not been determined. This article provides an overview of the association of FSs with neurodevelopmental outcomes, outlining both the underlying mechanisms and the possible appropriate clinical biomarkers, from histological changes to cellular molecular mechanisms. The hippocampus is the brain region most significantly altered after FSs, but the motor cortex and subcortical white matter may also be involved in the development disorders induced by FSs. The occurrence of multiple diseases after FSs may share common mechanisms, and the long-term role of inflammation and γ-aminobutyric acid (GABA) system are currently well studied.
Economic analysis of remote monitoring in patients with implantable cardioverter defibrillators or cardiac resynchronization therapy defibrillators in the Trento area, Italy
Authors: Marini Massimiliano , Videsott Lodovica , Dalle Fratte Chiara Francesca , Francesconi Andrea , Bonvicini Eleonora , Quintarelli Silvia , Martin Marta , Guarracini Fabrizio , Coser Alessio , Benetollo Pier Paolo , Bonmassari Roberto , Boriani Giuseppe
Published: May 2023

Introduction

Remote monitoring (RM) technologies have the potential to improve patient care by increasing compliance, providing early indications of heart failure (HF), and potentially allowing for therapy optimization to prevent HF admissions. The aim of this retrospective study was to assess the clinical and economic consequences of RM vs. standard monitoring (SM) through in-office cardiology visits, in patients carrying a cardiac implantable electronic device (CIED).

Methods

Clinical and resource consumption data were extracted from the Electrophysiology Registry of the Trento Cardiology Unit, which has been systemically collecting patient information from January 2011 to February 2022. From a clinical standpoint, survival analysis was conducted, and incidence of cardiovascular (CV) related hospitalizations was measured. From an economic standpoint, direct costs of RM and SM were collected to compare the cost per treated patient over a 2-year time horizon. Propensity score matching (PSM) was used to reduce the effect of confounding biases and the unbalance of patient characteristics at baseline.

Results

In the enrollment period, N = 402 CIED patients met the inclusion criteria and were included in the analysis (N = 189 patients followed through SM; N = 213 patients followed through RM). After PSM, comparison was limited to N = 191 patients in each arm. After 2-years follow-up since CIED implantation, mortality rate for any cause was 1.6% in the RM group and 19.9% in the SM group (log-rank test, p < 0.0001). Also, a lower proportion of patients in the RM group (25.1%) were hospitalized for CV-related reasons, compared to the SM group (51.3%; p < 0.0001, two-sample test for proportions). Overall, the implementation of the RM program in the Trento territory was cost-saving in both payer and hospital perspectives. The investment required to fund RM (a fee for service in the payer perspective, and staffing costs for hospitals), was more than offset by the lower rate of hospitalizations for CV-related disease. RM adoption generated savings of −€4,771 and −€6,752 per patient in 2 years, in the payer and hospital perspective, respectively.

Conclusion

RM of patients carrying CIED improves short-term (2-years) morbidity and mortality risks, compared to SM and reduces direct management costs for both hospitals and healthcare services.
The first discovery of amber resin in Lichi Mélange, Eastern Taiwan
Authors: Pang Chi-Hsiu , Yang Tzu-Ruei , Chang Ying-Ju , Lin Shu-Hong , Shiau Liang-Jian , Chen Chih-Tung , Chang Chung-Pai , Lo Li
Published: May 2023

Amber is fossilized tree resin produced by the metabolism of vascular plants that has experienced various geological processes, including burial, compression, and heating. Therefore, most of the previously reported amber pieces were unearthed from sedimentary rocks. The record of amber in tectonic active regions, e.g., Taiwan, is extremely poor and has not been scientifically certified, leading to a poor understanding of the history of prehistoric flora in this region. This study reports a 1-cm yellow-brown amorphous resin interspersed in sandstone blocks in the Lichi Mélange at the southernmost tip of the Coastal Range in eastern Taiwan, representing the first official record of amber from the mélange unit and as well as in Taiwan. The results, in addition to the affirmation of the amber, show that the amber is composed of sesquiterpenes and triterpenoids, indicating a possible origin of dipterocarp trees that are absent in the paleobotanic record and modern flora in Taiwan. Furthermore, infrared spectra analysis shows its compositional similarity to the amber from Sumatra, Indonesia, which boasts modern dipterocarp forests. Petrographic analysis of the surrounding sandstone suggests that the amber was deposited into the continental margin and allocated to Taiwan through the arc-continental collision in ∼6–7 Ma. In summary, this study represents the first report of amber unearthed in the mélange unit and Taiwan. It shows that amber is a durable and reliable information carrier in accordance with biogeographic and tectonic evidence.
Equipping future teachers with innovative strategies that increase physical activity in the classroom: a hybrid implementation trial across three Australian universities
Authors: Lander Natalie J. , Mazzoli Emiliano , Essiet Inimfon A. , Telford Amanda , Ridley Kate , Symington Naomi , Salmon Jo
Published: May 2023

Introduction

TransformEd targets initial teacher education (ITE) to equip future teachers with innovative strategies that increase physical activity in the Primary school classroom.

Methods

This hybrid implementation-effectiveness trial investigated the effects of the TransformEd program when embedded in ITE degrees at two Australian universities (University 1 Single Unit offering; University 2 Dual Unit offering) over a 12-week period, on pre-service teachers’ perceived competence, confidence, and willingness to deliver active pedagogies, in comparison with a third ‘usual practice’ control university.

Results

There was a favourable intervention effect on the total teacher perceptions score among pre-service teachers in University 1 compared to the control group pre-service teachers. Further, there was a significant intervention effect on reduced perceived barriers to active strategies in University 1, and a significant increase in perceived effects of active strategies on Primary school student outcomes in University 2. Qualitative data suggested the program strengthened the connection between theory and practice (i.e., how pre-service teachers are educated in university and the way they teach in Primary schools). The program was motivating to both lecturers and pre-service teachers, resulted in them reflecting on their own teaching practice, and helped with pre-service teacher engagement.

Discussion

Recommendations for improvement included stronger and more explicit alignment with the Australian Professional Standards for Teachers.
Pathology Reporting in Neuroendocrine Neoplasms of the Digestive System: Everything You Always Wanted to Know but Were Too Afraid to Ask
Authors: Albertelli Manuela , Grillo Federica , Lo Calzo Fabio , Puliani Giulia , Rainone Carmen , Colao Annamaria Anita Livia , Faggiano Antongiulio ,   NIKE group
Published: May 2023

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals.
Perturbations in fatty acid metabolism and collagen production infer pathogenicity of a novel MBTPS2 variant in Osteogenesis imperfecta
Authors: Lim Pei Jin , Marcionelli Giulio , Srikanthan Pakeerathan , Ndarugendamwo Timothée , Pinner Jason , Rohrbach Marianne , Giunta Cecilia
Published: May 2023

Osteogenesis imperfecta (OI) is a heritable and chronically debilitating skeletal dysplasia. Patients with OI typically present with reduced bone mass, tendency for recurrent fractures, short stature and bowing deformities of the long bones. Mutations causative of OI have been identified in over 20 genes involved in collagen folding, posttranslational modification and processing, and in bone mineralization and osteoblast development. In 2016, we described the first X-linked recessive form of OI caused by MBTPS2 missense variants in patients with moderate to severe phenotypes. MBTPS2 encodes site-2 protease, a Golgi transmembrane protein that activates membrane-tethered transcription factors. These transcription factors regulate genes involved in lipid metabolism, bone and cartilage development, and ER stress response. The interpretation of genetic variants in MBTPS2 is complicated by the gene’s pleiotropic properties; MBTPS2 variants can also cause the dermatological conditions Ichthyosis Follicularis, Atrichia and Photophobia (IFAP), Keratosis Follicularis Spinulosa Decalvans (KFSD) and Olmsted syndrome (OS) without skeletal abnormalities typical of OI. Using control and patient-derived fibroblasts, we previously identified gene expression signatures that distinguish MBTPS2-OI from MBTPS2-IFAP/KFSD and observed stronger suppression of genes involved in fatty acid metabolism in MBTPS2-OI than in MBTPS2-IFAP/KFSD; this was coupled with alterations in the relative abundance of fatty acids in MBTPS2-OI. Furthermore, we observed a reduction in collagen deposition in the extracellular matrix by MBTPS2-OI fibroblasts. Here, we extrapolate our observations in the molecular signature unique to MBTPS2-OI to infer the pathogenicity of a novel MBTPS2 c.516A>C (p.Glu172Asp) variant of unknown significance in a male proband. The pregnancy was terminated at gestational week 21 after ultrasound scans showed bowing of femurs and tibiae and shortening of long bones particularly of the lower extremity; these were further confirmed by autopsy. By performing transcriptional analyses, gas chromatography-tandem mass spectrometry-based quantification of fatty acids and immunocytochemistry on fibroblasts derived from the umbilical cord of the proband, we observed perturbations in fatty acid metabolism and collagen production similar to what we previously described in MBTPS2-OI. These findings support pathogenicity of the MBTPS2 variant p.Glu172Asp as OI-causative and highlights the value of extrapolating molecular signatures identified in multiomics studies to characterize novel genetic variants.
Study of the quality index of groundwater (GWQI) and its use for irrigation purposes using the techniques of the geographic information system (GIS) of the plain Nekor-Ghiss (Morocco)
Authors: Elkhalki S. , Hamed R. , Jodeh S. , Ghalit M. , Elbarghmi R. , Azzaoui K. , Hanbali G. , Ben Zhir K. , Ait Taleb B. , Zarrouk A. , Lamhamdi A.
Published: May 2023

Groundwater is an indispensable source of water for drinking water supply, agriculture and industry worldwide. In arid and semi-arid regions, groundwater has seriously deteriorated in recent decades due to environmental changes, anthropogenic activities and marine intrusion. A total of 79 groundwater samples from the Nekor-Ghiss plain were sampled for major chemical ion analysis. These analyzes showed that the water samples were highly mineralized (>1,500 mg/L), with hardness (83.5% of the samples were very hard) and high concentrations of chemical elements, such as Cl−, Mg2+, Na+ and SO42-. To assess the quality of water in the study area for irrigation and consumption purposes, we used the quality index (GWQI) as well as a multi-criteria analysis based on “geographic information system” by assigning a weight to the different water quality parameters. Also, Piper and Durov diagram was investigated. The results of the study were focused on the water quality parameters of the collected groundwater samples, such as the sodium adsorption rate (SAR), the percentage of soluble sodium (Na%), the Residual Sodium Carbonate (RSC) and Permeability Index (PI) Majority of water samples in the study area are suitable to be used for irrigation. Magnesium Risk (MH) and Kelley’s Ratio Kelly ratio. 51.9% unsuitable samples to 59.49% good samples for irrigation purposes. Monitoring the quality and quantity of groundwater is crucial for the effective and sustainable management of this valuable resource. According to the results obtained, it appears that 92% of all the samples are located in the domain of frequent recharge waters of limestone and dolomitic aquifers, namely, Ca-Mg-HCO3. About 8% of the samples measured have a composition of the Ca-Na-Mg-HCO3 type.