bluuebunny/crossref_metadata_2025 huggingface dataset:
Physiological monitoring and monitoring of health-saving activity in the process of physical education of students
Authors: Kapilevich L. V. , Shil’ko V. G. , Kabachkova A. V.
Published: June 2020

The enhancement of physical education of students under conditions of humanization of education assumes, first, the organization of monitoring, which is a part of the education process and is oriented at the permanent observation, evaluation, analysis, and correction of this process and its results. Second, the results of the monitoring are the starting point for the projection, formation, and correction of the education process through the change of its conditions such as the introduction of differentiation in the need in students’ sport exercises and level differentiation in the degree of formation of motivation to exercises, methodic and physical efficiency. The gathering of combined information about indices of physical education of students will allow the optimization of the efficiency and correction of used physical education programs.
Т-regulatory cells in atopic dermatitis immune response
Authors: Gonsorunova D. S. , Ogorodova L. M. , Fyodorova O. S. , Kamaltynova Ye. M. , Belonogova Ye. G. , Kremer Ye. E.
Published: June 2020

Atopic dermatitis — is a chronic disease, with immune mechanisms leading to high level of immunoglobulin Е and abnormal skin reactivity. The current review is presenting the experimental and clinical study results regarding to Т-regulatory cells participation in atopic dermatitis immune response.
The intraoperative methods of hemostasis during liver surgeries
Authors: Dambayev G. Ts. , Baikov A. N. , Semichev Ye. V. , Shpisman M. N. , Aleinik A. N. , Deneko O. I. , Bushlanov P. S.
Published: June 2020

This article deals with a short analysis of intraoperative hemostasis in parenchymatous organs by the example of liver. A brief historical survey is given. The hemostatic sutures developed by different formers and the defects of hemostatic sutures are considered. There are some features of instrumental hemostasis, its advantages and disadvantages. The description of the new developed devices on basis of cold plasma, the hemostatic and antiseptic properties of the devices are presented.
Antioxidant effects in the mechanism of antiulcer action of Pinostrobin Oxime and caper extract
Authors: Shulgau Z.T., Z. T. , Arystan L. I. , Shaikenova Zh. S. , Adekenov S. M.
Published: June 2020

The possibility of using pinostrobin oxime and caper extract to decrease the intensity of lipid peroxidation and endointoxication in rats with chronic acetate ulcer is studied. It is found that the studied substances decrease the intensity of lipid peroxidation processes and the level of medium-molecular-weight (MMW) complexes in the blood of experimental animals.
Elaboration of quantitative method of Mediborol in its medical product
Authors: Krasnov Ye. A. , Shelekhova V. A.
Published: June 2020

Possibility of quantitative definition of mediborol in oil solutions is shown by the method of Firordta and least-squares method for spectrophotometric analysis. The developed technique appreciably allows us to increase the measurement accuracy as compared with the direct spectrophotometric analysis. The error of the analysis does not exceed 1,36% for solution of mediborol in peachy oil and 0,83% in olive oil.
Biologycal activity of Urtica cannabina L. extract
Authors: Gubin K. V. , Sen'kova A. V. , Khanina M. A. , Ageyeva T. A.
Published: June 2020

The dry Urtica cannabina L. extract, containing complex of biologically active materials in different regimes introduced to mice with conducting poly-chemotherapy for the purpose of reduction in its toxicity. As a result a pathomorphological study of the liver of mice it was proven that the extract of U. cannabina decreases the manifestation of the toxic action (dystrophia and the necrosis of the hepatocytes) of poly-chemotherapy on a liver. Most effective is the regime of extract introduction before and after poly-chemotherapy.
Experimental study of 4-aminobenzoilgidrazid succinic acid antidiabetic activity
Authors: Kotegov V. P. , Kolotova N. V. , Bulatov I. P. , Bludova M. Yu. , Pestov G. N. , Andreyev A. I.
Published: June 2020

In experiments on intact rats and rats with steroid diabetes was studied the effects of prolonged introduction of 4-aminobenzoilgidrazid of succinic acid. It is shown that this substance potentiates the hypoglycemic effect of insulin, increases glucose tolerance and reduces the hyperglycemic effect of adrenaline.
Pharmacological activity of polyphenolic connections in the conditions of alcoholic intoxication
Authors: Krikova A. V. , Novikov V. Ye. , Novikov A. S. , Stepanova E. F.
Published: June 2020

In experiment it is shown cardionegative action of spirit ethyl. Damaging effects can be fixed with the help bioimpedansometry which is one of ways of an estimation of a condition of cellular membranes. It is noticed, that indicators bioimpedansometry correlate with presence of morphological changes in fabrics under the influence of ethyl spirit and the medicinal substances lowering a medicinal intoxication.
Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids
Authors: Pulina N. A. , Krasnova A. I. , Sobin F. V. , Yushkova T. A. , Yushkov V. V.
Published: June 2020

The paper deals with directed synthesis and study of hypoglycemic activity of N-heterylamides of 4-aryl-2-hydroxy-4-oxo-2- butenoic and 4-aryl-3-bromo-2, 4-dioxobutanoic acids. Hypoglycemic activity of 28 compounds was under research. Some regularities of the influence of the heterocyclic moiety structure and the bromine atom on the activity of the compounds were obtained. Two low-toxic and highly active substances comparable in potency with the reference drug were identified.
The influence of nanosecond microwave pulses on the regeneration processes
Authors: Knyazeva I. R. , Medvedev M. A. , Zharkova L. P. , Gostyukhina A. A. , Kutenkov O. P. , Rostov V. V. , Bolshakov M. A.
Published: June 2020

The effects of pulse periodic microwaves (10 GHz, duration of pulse 100 ns, pulse repetition frequency 4—19 pps, peak power density 40—1 520 W/cm2 ) on the reparative regeneration of full-thickness skin wounds on mice was investigated. This effect depends on the pulse repetition frequency and peak power density.
Contrast agents for ultrasound examination
Authors: Fomina S. V. , Zavadovskaya V. D. , Yusubov M. S. , Drygunova L. A. , Filimonov V. D.
Published: June 2020

Ultrasound examination is the integral component of diagnostic imaging and it is widely used method for medical visualization in Russian clinical medicine. Modern diagnostic imaging inseparably linked with use of contrast agents. Currently, the use of echo-contrast agents is a compulsory condition for patient's examination with constant improvement and development of new echo-contrast agents. In Russia these agents are not widely used due to insufficient duration contrast procedure and high cost of examination. However, during the last years there are factors promoting the development and introduction of echo-contrast agents into the national market.
Combined drug-free treatment of patients with gall-bladder dysfunction at chronic opisthorchosis
Authors: Poddubnaya O. A. , Schyogoleva S. F.
Published: June 2020

The development of a combined approach to the treatment of patients with gall-bladder dysfunctions in combination with chronic opisthorhosis with allowance for all aspects of the pathological process remains an urgent problem of clinical medicine. The addition of tonic procedures to the treatment increases the adaptation capability of an organism. Symptomatic factors (pulsed travelling magnetic field) favors normalization of the functional state of the biliary excretion system. The anthelminthic therapy (ecorsol herbal drug) results in specific antiparasitic effect. In combination, the used methods provide for the high effect of performed medical and prevented measures favoring not only the reduction of pathological process, but also the prevention of its progress, which is great practical importance.
The role disorders at system of cytokines in pathogenesis of Helicobacter pilory-associated pathology
Authors: Ageyeva Ye. S. , Shtygasheva O. V. , Iptyshev V. M. , Ryazantseva N. V.
Published: June 2020

Fifty five Khakas people with Helicobacter pylori-associated ulcer disease and chronic gastritis were examined in order to estimate the production of IL-2, IL-4, and IL-10 interleukins in patients with chronic Helicobacter pylori persistence. The subpopulation composition of lymphocytes of peripheral blood was determined by the method of flow-through cytofluorometry. Apoptosis was estimated by the method of optical microscopy. The IL-2, IL-4, IL-10 production in supernatants was determined by the solidphase immunoenzymometric method. Changes revealed in the blood of patients infected with Helicobacter pylori were characterized by the increased amount and subpopulation disbalance of lymphocytes, apoptosis modification, and depletion of lymphocyte functional activity.
TUBERCULOSIS IN CHILDREN IN IRKUTSK REGION
Authors: Zorkaltseva Ye. Yu. , Pugacheva S. V. , Chukavina I. Yu.
Published: June 2020

Epidemiology situation and factors its determinates was analyzed. Reports of tuberculosis hospitals used and results of observed two hundred and sixty-three children with tuberculosis. It was determinate that reasons of increase children morbidity of tuberculosis: bad epidemiology situation in adults in region, not all adult patients with tuberculosis was hospitalized, defects of prophylactic of tuberculosis. Tuberculosis in children having contact with tuberculosis was determinates earlier and structure of clinical forms was better than in children which have no contact.
DIAGNOSTIC SIGNIFICANCE OF LOCAL ALTERATIONS OF BRONCHIAL TREE IN THE COMPREHENSIVE SURVEY OF PATIENTS WITH PULMONARY TUBERCULOSIS
Authors: Serov O. A. , Kolpakova T. A. , Krasnov V. A.
Published: June 2020

The difficulties in the interpretation of identified during bronchoscopy local bronchi alterations in patients with pulmonary tuberculosis make this problem of current interest. The comprehensive survey of 287 patients revealed the specific origin of local alterations of bronchial tree in 50% of patients with destruc-tive pulmonary tuberculosis and with bacterioexcretion
LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN
Authors: Khlusov I. A. , Igumnov V. A. , Choukhnova D. I. , Mytasova O. L. , Zaitsev K. V. , Abdulkina N. G. , Zaitsev A. A. , Kolesova L. Yu.
Published: June 2020

Local and system influence the Repleri gel implants on the base of hyaluronic acid used to correct age-related changes in skin has been studied. Human stromal stem cells with CD44 membrane receptor to hyaluronic acid migrates in vitro into gel structure and maturates morphologically in fibroblast-like forms stained positively with acid phosphatase. Repleri gels implantation in the group of women with local and system age-related changes in homeostasis has positive local effect connected with full deletion of nasolabial fold in facial skin. Repleri gels injection has been decreasing during 1 year the system indices of real biological age as compared with chronological (passport) one. Lipoproteins and aspartate aminotransferase concentrations diminished statistically in women blood. An effect revealed may be considered as potential way of anti-age therapy of not only skin but parenchymal organs. At the same time, a long-term control of homeostasis distant indices in women with serious changes in parenchymal organs is necessary after local Repleri gels injection because of organism’s hormonal reactions.
MORPHOLOGICAL FEATURES OF LUNG STRUCTURE AND FUNCTIONAL ACTIVITY OF THE AIRWAYS OF GUINEA PIGS AFTER LONG-TERM EXPOSURE WITH NANOSIZED MAGNETITE A
Authors: Abramenko Ye. Ye. , Nosarev A. V. , Smaglyi L. V. , Kapilevich L. V. , D’yakova Ye. Yu. , Tabayeva A. M. , Kironenko T. A. , Selivanova V. S.
Published: June 2020

The results of study, in which we examined the influence of nanosized magnetite on breath organs histological structure and contractility activity of the airways of guinea pigs by method of mechanography has been presented. In the lungs of experimental animals an inflammatory response developed as a result of long-term inhalation intake of nanosized magnetite. Also the functional status of the airways changed and appeared as changing of amplitude of contractility response under the action of histamine.
HEPATOPROTECTIVE ACTION OF POLAR LIPIDS OF MARAL ANTLERS AND PEAT IN EXPERIMENTAL LIVER DAMAGE CAUSED BY ISONIAZIDE AND PARACETAMOL
Authors: Yatsenkov A. I.
Published: June 2020

In experimental liver pathology caused by isoniazide or paracetamol administration to albino rats lipids derived from maral antlers and peat decreased the blood activity of aminotransferases, γ-glutamyltranspeptidase, acid and alkaline phosphatases, phospholipase А, content of common bilirubin, activated the detoxication of biliribin, ammonium and phenols, inhibited the liver formation of dienic conjugates, Schiff’s bases, malonic dialdehyde, improve the reduced glutathione function. Maral anthlers and peat lipids in effective doses 30 and 60 mg/kg had the more pronounced hepatoprotective and antioxidant action than lipids in dose 10 mg/kg and essentiale forte N.
DEVELOPMENT OF THE MODELS TO OPTIMIZATION IN SYSTEM BIOTEHNICAL OF THE PLAYING CAR TRAINING
Authors: Pyatakovich F. A. , Yakunchenko T. I. , Makkonen K. F.
Published: June 2020

The Purpose – its were developed multiparametric models and algorithms of the optimization playing training biooperated. In work are used methods of the system analysis, modeling, system technical analysis and constructing, mathematical statistics, methods of the computer analysis heart rate variability by means of sensor of the pulse and breathings.

The Conclusion: its were designed two models of strategy playing, one – with installation on avoid of the failures and the second – on achievement of the success. The algorithms of the success and efficiency were formed for period of the termination of the biooperated play.
ADHD GROUP RISK SCREENING BASED ON GAME BIOFEEDBACK
Authors: Jafarova O. A. , Grebneva O. L. , Stoller I. A.
Published: June 2020

To organize the systematic selection and formation of risk groups regarding attention disorder, the algorithm of screening diagnostics for primary school students was developed using game biofeedback based on     heart     rate     and     time     of    response    to     suddenly    appearing    stimuli (test     "Rally").    Proposedareclassificationrules for including the subjects into the risk group, the intermediate group, and the group with satisfactory test results.
GAME BIOFEEDBACK TECHNOLOGY IN ATTENTION DEFICIT/HYPERACTIVITY DISORDER
Authors: Stoller I. A. , Verevkin Ye. G. , Sukholentseva M. V.
Published: June 2020

We continue the study of students with attention deficit hyperactivity disorder when using betastimulating game neurofeedback. The dynamics of segmental characteristics of the alpha rhythm and θ/β ratio for different groups of successful training. Evaluate the effectiveness of training in terms of the number of ADHD symptoms (at the beginning and end of the training).
ANALYSIS ON HOW GAME BIOFEEDBACK AFFECTS PSYCHO-PHYSIOLOGICAL PARAMETERS OF SINGLE-COMBAT SPORTSMEN WITH VEGETATIVE STATUS FAILURE
Authors: Kuznetsova L. A. , Guvakova I. V.
Published: June 2020

106 single-combat sportsmen took part in this study: 76 sportsmen with dominant activity of sympathetic part of vegetative nervous system and pronounced strain and overstrain of regulatory systems. Control group consists of 30 healthy sportsmen. Game biofeedback showed considerable advantages over methods of pedagogical correction in improving psycho-physiological parameters.
PSYCHOPHYSIOLOGICAL CHARACTERISTICS OF WOMEN IN DEPENDENCE ON THE OVARIOHORMONAL CYCLE PHASE AND PROGESTERONE ACTIVITY (PART 2)
Authors: Muravlyova K. B. , Kuzminova O. I. , Petrova S. I. , Skoraya M. V. , Bazanova O. M.
Published: June 2020

With the aim to identify the effects of menstrual cycle phase on the alpha EEG characteristics the 78 women aged 18–27 years were studied in a within-subject design Half the subjects began investigation at their follicular phase and half at their luteal phase (LP). The alpha peak frequency, alpha band width and power inalpha-2 range are highest, but power in alpha 1 and activation are lowest in LP that is associated with the highest saliva progesterone level.
FEATURES KALLIKREIN-KININ SYSTEMS AND DYSFUNCTIONS ENDOTHELIUM AT NEWBORNS WITH HYPOXEMIC DEFEAT OF THE CENTRAL NERVOUS SYSTEM
Authors: Zhelev V. A. , Pogudina A. S. , Gorev V. V.
Published: June 2020

Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions. 201 prematurely newborn of various degree gestation with hypoxemic affection of the central nervous system were under observation. We have studied the activity of kallikrein, kallikreinogen in newborns with hypoxic-ischemic encephalopathy. The activity of the kallikrein-kinin system was increased in all the groups against the background of the decreased inhibitory activity of blood plasma of different intensity, which can be used for the prediction of the course of diseases.
EFFECT OF POLYPHENOLIC COMPOUNDS ISOLATED FROM CARTHAMUS TINCTORIUS AND CALENDULA OFFICINALIS L., ON FUNCTIONAL ACTIVITY OF IMMUNE CELLS UNDER CONDITIONS OF CYTOSTATIC IMMUNOSUPPRESSION
Authors: Masnaya N. V. , Isaikina N. V. , Sherstoboev Ye. Yu. , Kalinkina G. I.
Published: June 2020

The purpose of the study – to study the effect of polyphenolic compounds extracted from the flowers of safflower oil and calendula, the functional activity of immune cells in cytotoxic immune suppression.Conventional methods determined the total number of splenocytes, relative (%) and absolute (106), the number of antibody-forming cells (AFC) in the spleen of mice by local hemolysis by Cunningham.Evaluated the effect of compounds of natural origin on the cellular immune response in the delayed-type hypersensitivity (DTH). Phagocytic activity of peritoneal macrophages was determined by the method based on the intensity of their capture ink particles. We studied the functional activity of peritoneal macrophages by NBT test (spontaneous and stimulated). Studies were conducted on male mice Category 1 (conventional linear mouse) line CBA/CaLac aged 2–2.5 months, weighing 20–22 g. After the introduction mice line CBA/CaLac of polyphenolic compounds derived from flowers of Carthamus tinctorius and flowers of Calendula officinalis L. during the 5-day course in dose 50 mg/kg was observed stimulation of the humoral immune response (total number of splenocytes, the number of antibodies in the spleen cells) and the functional activity of macrophages and Immunomodulating effect on the humoral immunity and the functional activity of macrophages after a single injection of cyclophosphamide in dose 250 mg/kg. Immunotropic activity of polyphenolic compounds is higher than that those of the reference product of tincture of Echinacea purpurea.
CLASSIFICATION OF DEFECTS PHARMACOTHERAPY AS THE BASIS OF QUALITY ASSESSMENT OF DRUG THERAPY IN HEALTHCARE
Authors: Khafisianova R. Kh. , Burykin I. M. , Aleeva G. N.
Published: June 2020

Optimization of pharmacotherapy, as improving the quality of care is an important goal of modern medicine. The solution to this problem can be realized with the development and adoption of clear formal criteria. Using aprocess-based approach, we have developed a method for detecting defects in pharmacotherapy. We have analyzed the prospects of using this approach to research the quality of pharmacotherapy in health care and the formation of national programs to improve the quality of care.
CLINICAL AND EEG PREDICTORS OF INCREASED FREQUENCY OF GENERALIZED SEIZURES IN GESTATIONAL AND POSTGRAVIDARUM PERIOD
Authors: Grebenyuk O. V. , Svetlik M. V. , Alifiriva V. M. , Yevtushenko I. D. , Bochkov Yu. A. , Stepanov I. A.
Published: June 2020

We investigated the predictors of increased seizures’ frequency among women with various forms of idiopathic generalized epilepsies (IGE) in the gestational and postgravid period. We observed 41 patients with Idiopathic generalized epilepsy (IGE) before, during and after pregnancy. During the period of observation EEG was recorded in the states of relaxed and active awakeness and sleeping. Patients, who have stopped to take anticonvulsants before pregnancy, have had increased frequency of seizures, more than1 ina year, with interictal epileptiform discharges in a state of relaxed and active awakeness. Increased seizures after pregnancy was observed in patients with interictal epileptiform discharges during sleep. The results can be used during the preparation of pregravid women with IGE.
COMPARATIVE ANALYSIS OF RISK FACTORS FOR STROKE AMONG NATIVE PEOPLES REPUBLIC OF TYVA
Authors: Doronin B. M. , Mongush Kh. D. , Ondar A. B. , Chylbak-ool R. Ch.
Published: June 2020

Objective: a comparative analysis of risk factors for stroke in patients with stroke, depending on sex, analysis of the frequency of occurrence of risk factors in patients and healthy people Tuvan nationality. Materials and methods. A case-control study of major risk factors for ischemic stroke (hypertension, family history, cardiac pathology, diabetes, etc.) in the two groups. Results. The first place is in the frequency of hypertension, family history and then, at the last-myocardial infarction. Conclusions. Among the population of Tuva has been a clear upward trend in ischemic stroke associated primarily with a high prevalence of hypertension, inadequacy of its treatment, as well as alcohol abuse.
CLINICAL, NEUROPHYSIOLOGICAL AND IMMUNOLOGICAL STUDIES OF CANCER PATIENTS WITH LESIONS OF THE PERIPHERAL NERVES
Authors: Korolyova Ye. S. , Alifirova V. M. , Goldberg V. Ye. , Novikova N. S. , Zhukova I. A.
Published: June 2020

Clinical electrophysiological and immunological studies of 88 cancer patients showed that in breast cancer and small lung cancer takes place symmetric, distal, sensory-motor, axonal-demyelinating polyneuropathy. Autoimmune nature of the disease confirmed onconeural antigens detected in the serum of more than half of the study participants.
VALIDITY OF STARTING ANTICONVULSANT THERAPY AFTER FIRST CONVULSIVE SEIZURE IN CHILDREN
Authors: Fetisova Ye. S. , Maslova N. N.
Published: June 2020

As a result of survey of 190 children with paroksyzmal conditions, there were revealed 14, whom antiepileptik therapy was prescribed after fist seizure. It was defined that such therapeutic tactics may be justified in patients with organik damage of the brain, focal neurological symptomatik in case of spontaneous emergence of the first seizure.
CHOICE OF THERAPY OF POSTOPERATIVE NEUROLOGIC COMPLICATIONS AND PREVENTIVE MAINTENANCE OF DISTRESSES OF THE HIGHEST MENTAL FUNCTIONS BY CAROTID ENDARTERECTOMY
Authors: Shmelev V. V. , Neimark M. I.
Published: June 2020

At patients with carotid endarterectomy the relative assessment of total intravenous anaesthesia with use propofol, penetrating blockage of a cervical plexus and inhalation sevofluran is made. Markers of cerebral damage, a state of the highest mental functions were investigated. It is shown that for each kind of anaesthesia are characteristic specific level neuronal damages that affects on a state of the highest mental functions, number and character of postoperative complications. In therapy of neurologic complications and preventive maintenance cognitive distresses clinical efficacy ceracson is shown.
IMPROVEMENT METHODS OF DIAGNOSIS THE VISUAL ANALYSER OF PATIENTS WITH MULTIPLE SCLEROSIS
Authors: Kovalenko A. V. , Bisaga G. N. , Boiko E. V. , Kovalenko I. Yu.
Published: June 2020

137 (274 eyes) relapsing-remitting multiple sclerosis patients have been given detailed neuroophthalmologic examination. 58 of these patients (74 eyes) had a previous history of optic neuritis. As a result, the most informative methods of examination have been identified. These include the estimation of the frequency characteristics of the vision (vizokontrastoperimetriya, low-contrast tests Sloan), standard static automated perimetry, pattern visual evoked potentials, and optical coherence tomography which is used to measure macular volumes and retinal nerve fiber layer thickness. The above – mentioned methods make it possible to reveal the involvement of the optic analyzer in the inflammatory and neurodegenerative process at the pre-clinical stage. The obtained results allow us to recommend inclusion of the methods in the standard algorithm for the examination of patients with probable multiple sclerosis.
ACTIVITIES RESULTS AIMED AT IMPROVED MEDICAL ASSISTANCE TO THE VASCULAR PATIENTS IN TOMSK REGION
Authors: Plotnikov D. M. , Ivannikova O. A. , Alifirova A. M. , Alekseyeva L. N. , Petlin Yu. V.
Published: June 2020

Acute disorders of cerebral circulation remain serious medical and social problem associated with high disability and mortality rates. Since 2011 Tomsk oblast is a participating member of the medical campaign aimed at improved medical services to the vascular patients. The preliminary implementation data analysis for 2012 revealed improvement of most of the indices of medical support to patients suffering from acute cerebral circulation; increased number of the in-patient cases (Regional Vascular Center and primary vascular department), decreased lethality rates from strokes, specifically hemorrhagic cases. Strict observance of the Regulations on Medical Assistance for stroke patients and the using of modern methods of therapy allowed to decrease hospital mortality in the Primary Vascular Departments and early mortality in the Regional Vascular Center. The active implementation of neurorehabilitation approaches resulted in the increased number of patients who do not require third parties’ assistance. Analysis of the work of the departments helped to identifying current problems and perspectives of further development of special medical care for stroke patients.
REVISING THE QUESTION OF TERMINOLOGY AND CLASSIFICATION OF BRUXISM
Authors: Boykova E. I. , Geletin P. N. , Ginali N. V. , Maslova N. N. , Yureva N. V.
Published: June 2020

To date, there is no consolidated opinion regarding the terminology and classification of bruxism. The following terms are used for determination of unconscious strong compression teeth: “effect Karolyi”, “stridor dentium”, occlusal neurosis, odonterizm, “bruksomaniya”, “parafunctional activity of masticatory muscles”. Because of the disease nature the polyethiologic symptom group is develops that complicates the disease representation. The authors are recommend the usage “bruxism” term in everyday practice and as the most well-established and popular in the medical practice. The primary point of our study was identification of the pathognomonic parameters on electroencephalogram in patients with bruxism. As result of the study it was identified that the border type of EEG was registered statistically higher in pa-tients with parafunctional activity of masticatory muscles than in control group. The results are consistent with global trends, in respect that neuroscientists are systematize bruxism to “parasomnias”, (according to ICD 10) which are characterized by minor changes in the basic rhythm which were identical to findings that we revealed in the study group.
THE COMPARATIVE ASSESSMENT THE EFFECTIVENESS OF TREATMENT THE NERVE ROOT COMPRESS SYNDROME USING THE ANTERIOR AND POSTERIOR APPROACHES OF PATIENTS WITH COMBINED LATERAL LUMBAR STENOSIS
Authors: Kolotov Ye. B. , Aminov R. R. , Kolotova Ye. V. , Kelmakov V. V. , Zhilina N. M.
Published: June 2020

Objective: to compare the therapeutic possibility of the decompressiveviedecompressive with stabilization surgeries using the standard posterior and anterior retroperitoneal approaches in patients with combination of inherent and obtaining lateral stenosis and to demonstrate the adequacy of using. At the main group we removed the herniated disc with stabilization using anterior and posterior approaches – 82 patients. The control group was treated by standard microdiscectomy – 40 patients. More excellent and good results were in the main group where decompression was combined with stabilization, and at the same group were less negative results. The decompressive-stabilizing surgery with anterior interbody fusion is a pathogenetic and technically adequate treatment for combined lateral stenosis.
MODERN PHYSICAL THERAPY IN THE EARLY POSTOPERATIVE REHABILITATION OF PATIENTS WITH CHOLELITHIASIS
Authors: Poddubnaya O. A. , Marsheva S. I.
Published: June 2020

Early postoperative rehabilitation of patients with cholelithiasis is aimed at improving the function of bile secretion, adaptability and normalization of psycho-vegetative state body, which in the aggregate prevents progression of the disease and reduces the risk of postcholecystectomy violations. Use in rehabilitation activities fresh mineral water, magnetic-laser and EHF-therapy allows to receive significant improvement of the studied parameters in a significant improvement and normalization of clinical and laboratory indicators, increase adaptive capacity and normalization of psychoemotional and vegetative status of the organism. It is provides immediate high efficiency of the activities (94.7%) of early postoperative rehabilitation of patients with cholelithiasis, which reduces the risk of the development of postcholecystectomy violations and prevents progression of the disease.
DETECTION OF MYOCARDIAL VIABILITY IN ISСHAEMIC DAMAGE USING MAGNETIC RESONANCE AND EMISSION TOMOGRAPHY
Authors: Ussov V. Yu. , Bogunetsky A. A.
Published: June 2020

A review of modern methods of magnetic resonance imaging (MRI) and emission tomography (singlephoton emission and positron emission computer tomography – SPECT and PET) as toos for diagnosis and prognosis of myocardial ischaemic damage, in particular in coronary revascularization. The definition of term “myocardial viability” is discussed. It has been shown that the integrity of blood-tissue barrier between myocardium and microcirculatory vessels is the most sensitive marker of tissue viability and of functional integrity of myocardium. It’s evaluation by means of contrast-enhanced MRI of myocardium is the most available and most precise technique of diagnosis and prognosis both in patients with postinfarction myocardiosclerosis and in patients with coronary disease without myocardial infarction. It is proposed that in the nearest future the combination of MR-coronarography and contrast-enhanced MRI of myocardium will provide a possibility to obtain the full set of data necessary for planning of endovascular and surgical treatment of various forms of coronary heart disease. PET and SPECT techniques currently are of some essential interest for pathophysiologic research of coronary ishaemia in clinical and experimental studies as well as for qualitative visual studies of pharmacokinetics.
AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS
Authors: Dvornichenko М. V.
Published: June 2020

In order to evaluate cytogenetic effect of nanocomposite materials used in traumatology and orthopedics an investigation of chromosomal aberration ins in the culture of lymphocytes short-term contacted with artificial material (nanostructured titanium samples of implants bearing bilateral calcium phosphate coating) in patients with dysplasia of connective tissue (DCT) and osteogenesis imperfecta (OI) has been conducted. A reduction of percent of aberrant cells having single or/and paired chromosomal breaks as compared with spontaneous mutagenesis (without model samples) was revealed under introduced biocompatible composites into blood cell cultures of patients with DCT or OI. Analysis of frequency and spectrum of chromosomal aberrations in blood cells can be considered as potential prognostic criterion and a predictor of implant’s efficacy in the surgical treatment of DCT and OI complications.
RADIONUCLIDE INDICATION OF SENTINEL LYMPH NODES IN LARYNX AND LARYNGOPHARYNX CANCER
Authors: Sinilkin I. G. , Chernov V. I. , Choinzonov Ye. L. , Chizhevskaya S. Yu. , Titskaya A. A. , Zelchan R. V.
Published: June 2020

Aim: to determine the possibility of radionuclide methods in the identification of "sentinel" lymph node (SLN) in larynx and laryngopharynx cancer patients.Material and methods: 17 patients with larynx and laryngopharynx cancer were included in research. In all patients for SLN visualization nanocolloid radiopharmaceutical was injection around tumor into mucous coat with the subsequent SPECT and radioguided study.Results: Sensitivity and specificity of SPECT and radioguided study for SLN identification were 100%. We found 22 SLN in 17 patients (from 1 to 2 per patient, on average 1.3). Most often SLN were located in the III level of a neck (lymph nodes around of carotid arteries) – 12 SLN (54.5%) and IIA level (under lower jaw lymph nodes) – 6 (27.2%). One SLN (4.5%) was localized in IV level and 3 nodes (13.6%) in VI level. In 2 patients (11.8%) metastasis in SLN were found. In these patients within 2 years cancer progressing was revealed. Fifteen patients (88.2%) had no metastatic in SLN and had no progressing of a cancer.Conclusions: Sensitivity and specificity of SPECT and radioguided study for SLN identification are 100%. In patients with metastatic SLN radical surgery with lymph node dissection is helpful.
ULTRASONIC EXAMINATION OF VENTILATION TUBES PATENCY IN PATIENTS WITH OTITIS MEDIA WITH EFFUSION AFTER TIMPANOSTOMY
Authors: Shcherbik N. V. , Konushkin V. A. , Starokha A. V. , Litvak M. M.
Published: June 2020

The aim of this study was to improve the accuracy and sensitivity of methods for ventilation tube patency evaluation after timpanostomy. New method of one-dimensional ultrasound middle ear sonography was developed. We studied ventilation tubes patency in 40 patients with otitis media with effusion, after timpanostomy. All patients tympanometry and one-dimensional ultrasound sonography was obtained at 4, 7th and one month after surgery. After timpanostomy in children with the otitis media with effusion, at 4 days after the surgery one-dimensional ultrasound sonography detected normal function of ventilation tubes in 75% patients. At the same time, according to tympanometry ventilation tube patency was recorded in 80% patients. On 7th  day after surgery one-dimensional ultrasound sonography detected normal function of ventilation tubes in 85% patients. According to tympanometry the 90% patients demonstrated normal ventilation tube function. One month after surgery one-dimensional ultrasound sonography detected normal function of ventilation tubes in 92.5% patients. At the same time, according to tympa nometry ventilation tube patency was recorded in 95% people. Calculation of ultrasound sonography sensitivity and specificity showed that the sensitivity of this process is 97.4%, specificity – 100%. The statistical significance of differences in ventilation tube patency assessment is not determined. Thus, we have proved one-dimensional ultrasound sonography the sensitive method for ventilation tubes patency validation. The method is simple, requires a bit of time for application, so it can be widely recommended for outpatient network.
MORPHOFUNCTIONAL CONDITION OF THE OVARIES AFTER HYSTERECTOMY
Authors: Fateyeva A. S. , Petrov I. A. , Tikhonovskaya O. A. , Logvinov S. V.
Published: June 2020

Estrogen-deficient state evolving after the removal of the uterus and blood disorders and innervation. In the present analytical review of the literature discusses the features of the structure and function of the ovaries in patients undergoing hysterectomy. Presents comparative data on preservation or removal of the fallopian tubes during a hysterectomy.
THE ROLE OF MICROBIAL COMMUNITIES OF AIRWAYS IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Fedosenko S. V. , Ogorodova L. M. , Karnaushkina M. A. , Kulikov Ye. S. , Deyev I. A. , Kirillova N. A.
Published: June 2020

This review summarizes the results of studies on the composition of microbial communities in the airways of healthy subjects and in patients with chronic obstructive pulmonary disease. Modern technologies of molecular-genetic identification methods of microorganisms allow to perform a deep analysis  of  the  respiratory  microbiom.  It  is  of  considerable  interest  to  determine  the  role  of  the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the efficacy of current therapy.
LEPTIN AS AN INDUCER OF INFLAMMATION AND OXIDATIVE STRESS BY METABOLIC SYNDROME
Authors: Bespalovа I. D.
Published: June 2020

Object of research: to explore the relationship of leptin level in blood serum with markers of systemic inflammation and spontaneous production of cytokines and reactive oxygen species by blood mononuclear leukocytes at metabolic syndrome.Material and methods. We conducted a study of 50 patients with essential hypertension stage II in conjunction with the metabolic syndrome. Along with a complete clinical, laboratory and instrumental examination adopted in specialized cardiological clinic, were determined the concentration of markers of systemic inflammation and leptin in blood serum, as well as the relative abundance of the surface markers CD4+-, CD8+-lymphocytes and CD36+-monocytes, the level of spontaneous production of proand antiinflammatory cytokines and active oxygen species by blood mononuclear leukocytes.Results. It was found that patients with essential hypertension stage II with the MS having hyperleptinemia statistically significantly differ both as greater activity of systemic inflammation, and have a greater percentage of CD4+-lymphocytes and a higher level of spontaneous production of blood mononuclear leukocytes a number of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, MCP-1) and reactive oxygen species.
ALGORITHM OF DIAGNOSTICS AND TREATMENT OF AN AGE-RELATED MACULAR DEGENERATION AT PATIENTS WITH CHRONIC PERIPHERAL UVEITIS
Authors: Khoroshikh Yu. I. , Krivosheina O. I. , Melekhin Ye. V.
Published: June 2020

The results of clinical trial of various approaches in treatment the exudative forms of macular degenerations, including age-related, against chronic slow intensity inflammatory process on the extreme retinal periphery of an eye are described in represented material. There were 91 patients (105 eyes) in the research with different types of an exudative macular degeneration. The general criteria of inclusion were: age of 18–80 years old, complaints to discomfort in eyes, a spot before an eye, distortions and decrease in the central sight, ophthalmoscopic symptoms of hypostasis in the central and peripheral areas of a retina. It is analyzed the general criteria of diagnostics and treatment of the disease in the article. Considering defeat of the chorioretinal structures located near the ora serrata at persons of young and advanced age. Practical recommendations to a choice of methods of diagnostics and treatment of various clinical and morphological forms of the disease are made. Screening methods of identification of patients with the peripheral uveitis are offered. The scheme of risk calculation of development the macular pathology at persons with changes on the extreme periphery of a retina, that can be used as a method of prevention of development predictively adverse of “wet" forms of an age-related macular degeneration, by means of timely sparing treatment at patients with chronic inflammatory diseases of eyes is given.
EFFECTS OF PHYSICAL EXERCISES ON TRIACYLGLYCEROL LEVEL IN SKELETAL MUSCLES IN DIETARY-INDUCED OBESE RATS
Authors: Yakimovich I. Yu. , Borodin D. A. , Podrezov I. K. , Ivanov V. V. , Vasiliyev V. N. , Kotlovsky M. Yu.
Published: June 2020

The accumulation of triacylglycerol in peripheral tissues is one of mechanisms of insulin resistance. This paper presents the investigation of the influence of aerobic and anaerobic physical exercises on triacylglycerol level in skeletal muscles and on insulin resistance in dietary-induced obese rats. It is estimated that a high-energy (HE) diet causes the accumulation of triacylglycerols in skeletal muscles that leads to high resistance to insulin. Aerobic and anaerobic physical exercises reduce the level of triacylglycerols in skeletal  muscles  and  raise  sensitivity to  insulin  in  obese  rats.  Physical  exercises  raise  the  level  of triacylglycerols in skeletal muscles in standard-diet rats that probably is the adaptation to high energy expenditure, but does not lead to high insulin resistance.
THE CHARACTERISTICS OF BLOOD LIPIDS OF MENOPAUSAL WOMEN WITH THE COMPENSATED HYPOTHYROIDISM WHICH RESULTS FROM AUTOIMMUNE THYROIDITIS
Authors: Malyshenko Yu. A. , Rymar O. D. , Ivanova M. V. , Shcherbakova L. V. , Zhinchyk S. F.
Published: June 2020

Purpose: to study the lipid profile, including of non-high-density lipoproteins cholesterol (non-HDL-C), in postmenopausal women with compensated hypothyroidism. The causes of hypothyroidism included Hashimoto thyroiditis.45 women with hypothyroidism participated in the study (mean ± sd, age (57.4 ± 7.7) years, disease duration (8.0 ± 6.4) years, the duration of postmenopause (6.4 ± 3.5) years). The mean dose of L-T4 (84.3 ± 28.5) μg/d. The control group – 85 women (mean ± sd, age (58.4 ± 5.4) years) no abnormalities of the thyroid gland, as well as other chronic diseases, which could have an impact on lipid metabolism.The main and control group were matched for age. Average BMI basic group than in controls: (31.6 ± 3.4) and (28.7 ± 4.6) kg/m2 respectively (p = 0.001). Obtained statistical differences in terms of TSH in the study and control groups: 2.15 and 1,22 mU/L (p = 0.001). Upon reaching euthyrosis against the background of hormone replacement therapy with thyroid hormones do not reach the target total cholesterol (TC), low density lipoproteins cholesterol (LDL-C): 5.81 ± 1.14, 3.67 ± 1.06 respectively.We obtain lower high-density lipoproteins cholesterol (HDL-C) levels in women with drug euthyroidism compared with the control group. Do not get the difference in the values non-HDL-C in the groups studied. In postmenopausal women with compensated hypothyroidism is defined negative correlation ATTPO with HDL-C. Mean values of blood TC, non-HDL-C, LDL-C levels in the groups exceed the optimal ones.
COMPLICATIONS AND OUTCOMES OF PREGNANCY IN GESTATIONAL DIABETES MELLITUS
Authors: Bondar I. A. , Malysheva A. S.
Published: June 2020

The aim of the study was to analyze the complications and examine the outcomes of pregnancy in women with compensated gestational diabetes mellitus.We studied outcomes and complications of pregnancy in 50 pregnant women with gestational diabetes mellitus, the effects of gestational diabetes on the fetus.The average age of pregnant women was (33.7 ± 5.7) years. The incidence of gestoses and placental insufficiency in compensated gestational diabetes mellitus was 84%, polyhydramnios – 36%, the fetus fetopathy – 48% of cases. Births in period occurred in 96% of cases, the frequency of fetal malformations consistent with population-based indicators.Gestational diabetes mellitus affects the development of gestosis and fetoplacental insufficiency, even when the compensation of carbohydrate metabolism after the diagnosis of gestational diabetes mellitus.
FACTORS ASSOCIATED WITH THE DEVELOPMENT OF SECONDARY HYPERPARATHYROIDISM IN PATIENTS WITH TYPE 1 DIABETES MELLITUS WITH DIABETIC NEPHROPATHY
Authors: Khantakova Ye. A.
Published: June 2020

Objective. To identify factors associated with the development of secondary hyperparathyroidism in patients with type 1 diabetes mellitus with diabetic nephropathy.Materials and methods. One hundred and one patients (males) with type 1 diabetes mellitus with diabetic nephropathy who were treated in endocrinology department of the Regional clinical hospital were examined. For the study of calcium and phosphorus metabolism in patients with type 1 diabetes mellitus, we investigated the following parameters in the blood plasma: level of intact parathyroid hormone, total calcium, ionized calcium, serum phosphorus.Results. The study showed that in patients with type 1 diabetes mellitus with diabetic nephropathy factors associated with the development of secondary hyperparathyroidism are: the age above 30 years old, the duration of diabetes for more than 15 years, reduction of glomerular filtration rate of less than70 ml/min/1,73 m2 and the development of anemia. Factor associated with the reduction of secondaryhyperparathyroidism is the level of glycated hemoglobin of more than 8%.Conclusion. Thus, patients with type 1 diabetes mellitus with diabetic nephropathy represent a group of increased risk for development of violations of calcium and phosphorus metabolism. Analysis of the factors associated with the occurrence of secondary hyperparathyroidism in diabetic nephropathy allowed to identify a group of high risk of development of this pathology.
EXPERIENCE WITH THE ROSINSULIN C IN COMBINATION WITH ORAL ANTIDIABETIC DRUGS IN PATIENTS WITH TYPE 2 DIABETES IN ROUTINE CLINICAL PRACTICE
Authors: Rymar O. D. , Ivanchikhin A. N. , Kozlova V. T. , Ruzaeva Ye. D. , Dolinskaya Yu. A.
Published: June 2020

This study aimed to estimate the efficacy and safety of intermediate-acting insulin Rosinsulin C in patients with type 2 diabetes mellitus inadequately controlled with oral antidiabetic drugs.The present study is a 6-month, prospective, uncontrolled, clinical experience evaluation study using insulin Rosinsulin С for type 2 diabetes patients in daily clinical practice. Episodes of hypoglycaemia, adverse events were recorded. The study included 28 patients with type 2 diabetes, 4 men and 24 women who treated with metformin in combination with sulfonylureas in the highest dose. Indicators of glycosylated hemoglobin (HbA1c) of 8 to 14%, the median HbA1c was 11 (10; 13)% of patients age 65 (57; 72) years, body mass index – 33 (30; 35) kg/m2, waist circumference – 105 (99; 111) cm, diabetes duration – 7 (2; 11) years. With the introduction of Rosinsulin С cartridges carried pen Autopen. At the start of the study and after 3 and 6 months, determined the level of HbA1c, fasting plasma glucose.After 6 months' treatment with Rosinsulin С in combination with oral antidiabetic drugs HbA1c was significantly lowered (–3%) (p = 0,001), fasting plasma glucose level decreased by 5 mmol/L (p = 0,001). There was not severe hypoglycemia during the observation period.This research showed that Rosinsulin C is effective and safe in the treatment of patients with type 2 diabetes who were decompensated with oral antidiabetic drugs and can be recommended for use as the initiation of insulin therapy in routine clinical practice.