bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Study on Online Prediction of TP2 Rolled Copper Tube Wall Thickness Based on Different Proxy Models
Authors: Yue Fengli , Sha Zhuo , Sun Hongyun , Liu Huan , Chen Dayong , Liu Jinsong , Chen Chuanlai
Published: November 2024

The wall thickness of the TP2 copper tube casting billet is not uniform after a three-roll planetary rotational rolling, which affects the wall thickness uniformity of the copper tube in the subsequent process. In order to study the influence of wall thickness at different positions of copper pipe after rolling on the wall thickness of copper pipe after joint drawing, an online ultrasonic test platform was used to measure the wall thickness of copper pipe after tying, and based on the test data, a finite element model of copper pipe billet was established, and the numerical simulation of joint drawing wall thickness was conducted. Based on the results of the ultrasonic testing experiment and finite element simulation, different neural network models were used to predict the joint tensile wall thickness with the data of the ultrasonic testing experiment as input and the results of finite element simulation as output. The prediction effect of different neural network models was compared, and the results showed that the prediction and fitting effect of the SVM model was better, but overfitting occurred during the fitting process. Furthermore, particle swarm optimization is used to optimize the penalty parameter C and the kernel parameter g in the SVM model. Compared with the traditional SVM model, the PSO–SVM model is more suitable for the prediction of joint tensile wall thickness, which can better guide the production to solve this problem.
The Impact of Temperature and Pressure on the Structural Stability of Solvated Solid-State Conformations of Bombyx mori Silk Fibroins: Insights from Molecular Dynamics Simulations
Authors: Nettey-Oppong Ezekiel Edward , Muhammad Riaz , Ali Ahmed , Jeong Hyun-Woo , Seok Young-Seek , Kim Seong-Wan , Choi Seung Ho
Published: November 2024

Bombyx mori silk fibroin is a promising biopolymer with notable mechanical strength, biocompatibility, and potential for diverse biomedical applications, such as tissue engineering scaffolds, and drug delivery. These properties are intrinsically linked to the structural characteristics of silk fibroin, making it essential to understand its molecular stability under varying environmental conditions. This study employed molecular dynamics simulations to examine the structural stability of silk I and silk II conformations of silk fibroin under changes in temperature (298 K to 378 K) and pressure (0.1 MPa to 700 MPa). Key parameters, including Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), and Radius of Gyration (Rg) were analyzed, along with non-bonded interactions such as van der Waals and electrostatic potential energy. Our findings demonstrate that both temperature and pressure exert a destabilizing effect on silk fibroin, with silk I exhibiting a higher susceptibility to destabilization compared to silk II. Additionally, pressure elevated the van der Waals energy in silk I, while temperature led to a reduction. In contrast, electrostatic potential energy remained unaffected by these environmental conditions, highlighting stable long-range interactions throughout the study. Silk II’s tightly packed β-sheet structure offers greater resilience to environmental changes, while the more flexible α-helices in silk I make it more susceptible to structural perturbations. These findings provide valuable insights into the atomic-level behavior of silk fibroin, contributing to a deeper understanding of its potential for applications in environments where mechanical or thermal stress is a factor. The study underscores the importance of computational approaches in exploring protein stability and supports the continued development of silk fibroin for biomedical and engineering applications.
Enhanced Electrochemical Performance of Carbon-Composited Co3O4 Microspheres as Anode Materials for Lithium-Ion Batteries
Authors: Maulana Achmad Yanuar , Kim Jongsik
Published: November 2024

Cobalt (II, III) oxide (Co3O4) has recently gained attention as an alternative anode material to commercial graphite in lithium-ion batteries (LIBs) due to its superior safety and large theoretical capacity of about 890 mAh g−1. However, its practical application is limited by poor electrical conductivity and rapid capacity degradation because of significant volume increases and structural strain during repeated lithiation/delithiation cycles. To address these issues, this work presents a novel approach to synthesizing carbon-composited Co3O4 microspheres (Co3O4@C), using abietic acid (AA) as a carbon source to increase conductivity and structural stability. The resulting Co3O4@C anodes show an impressive discharge capacity of 1557.4 mAh g−1 after 200 cycling processes at a current density of 0.1 C, representing a significant improvement over bare Co3O4. This study demonstrates the potential of carbon-compositing as a strategy to mitigate the limitations of Co3O4 and extend its cyclability, making it a viable candidate for next-generation LIB anodes.
Research Progress in Shape-Control Methods for Wire-Arc-Directed Energy Deposition
Authors: Wang Jie , Zhao Bo , Liu Yuanlin , Zhao Junjie , Ma Guangyu
Published: November 2024

Wire-arc-directed energy deposition (WA-DED) stands out as a highly efficient and adaptable technology for near-net-shaped metal manufacturing, with promising application prospects. However, the shape control capability of this technology is relatively underdeveloped, necessitating further refinement. This review summarizes the latest advancements in the shape control of WA-DED technology, covering four pivotal areas: the regulation of various process parameters, optimization of the deposition paths, control through auxiliary energy and mechanical fields, and synergy between additive and subtractive manufacturing approaches. Firstly, this review delves into the influence of deposition current, travel speed, wire feed speed and other parameters on the forming accuracy of additively manufactured parts. This section introduces control strategies such as heat input and dissipation management, torch orientation adjustment, droplet behavior regulation, and inter-layer temperature optimization. Secondly, various types of overlap models and techniques for designing overall deposition paths, which are essential for achieving desired part geometries, are summarized. Next, auxiliary fields for shape and property control, including magnetic field, ultrasonic field, and mechanical field, are discussed. Finally, the application of milling as a subtractive post-process is discussed, and the state-of-the-art integrated additive-subtractive manufacturing method is introduced. This comprehensive review is designed to provide valuable insights for researchers who are committed to addressing the forming defects associated with this process.
Correction: Montgomery-Smith, S.; Shy, C. Using Lie Derivatives with Dual Quaternions for Parallel Robots. Machines 2023, 11, 1056
Authors: Montgomery-Smith Stephen , Shy Cecil
Published: November 2024

In the published paper [...]
Incipient Fault Detection and Recognition of China Railway High-Speed (CRH) Suspension System Based on Probabilistic Relevant Principal Component Analysis (PRPCA) and Support Vector Machine (SVM)
Authors: Feng Kang , Wu Yunkai , Zhou Yang , Zhou Yijin
Published: November 2024

As a crucial component of CRH (China Railway High-speed) trains, the safety and stability of the suspension system are of paramount importance to the overall vehicle system. Based on the framework of probabilistic relevant principal component analysis (PRPCA), this paper proposes a novel method for incipient fault diagnosis in the CRH suspension system using PRPCA and support vector machine (SVM). Firstly, simulation data containing multiple types of fault information are obtained from the Simpack2018.1-Matlab2016a/Simulink co-simulation platform. Secondly, the nonlinear PRPCA approach, based on the Wasserstein distance, is employed for fault detection and data preprocessing in the suspension system. Furthermore, SVM is used for fault recognition, and the F1-Measure index is utilized for a comprehensive evaluation to assess the fault diagnosis performance more intuitively. Finally, based on the comparison results with traditional principal component analysis (PCA) and SVM-based methods, the proposed incipient fault diagnosis method demonstrates superior efficiency in fault detection and recognition. However, the proposed method is not very sensitive to sensor faults, and the performance of sensor fault diagnosis needs to be further improved in subsequent research.
Structural Elucidation and Antiviral Properties of Pannosides from the Halophyte Aster tripolium L.
Authors: Lee Jaeyoun , Song Jae-Hyoung , Mun Seo-Hyeon , Ko Hyun-Jeong , Um Soohyun , Kim Seung Hyun
Published: November 2024

Four previously undescribed pentacyclic triterpenoid saponins, pannosides F–I (1–4), were isolated from the halophyte Aster tripolium L. (Tripolium pannonicum), and their chemical structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry. Comprehensive structural analysis revealed the presence of distinct aglycone and glycosidic moieties, along with complex acylation patterns. The acyl chains of pannosides, 3-hydroxybutyrate (3-HB) residues, were derivatized with (S)- and (R)- phenylglycine methyl ester to resolve the absolute configurations of the chiral centers in 3-HB. Then, the acyl chain-containing saponins, pannosides were evaluated for their antiviral activities against enterovirus A71 (EV71), coxsackievirus B3 (CVB3), and rhinovirus 1B (HRV1B). Pannosides exhibited antiviral activities against HRV1B, EV71, and CVB3. These findings suggest that saponins from A. tripolium exhibit potential antiviral activities and could be further explored for their therapeutic applications.
Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study
Authors: Rolle Valeria , Chaveeva Petya , Diaz-Navarro Ander , Fernández-Buhigas Irene , Cuenca-Gómez Diana , Tilkova Tanya , Santacruz Belén , Pérez Teresa , Gil Maria M.
Published: November 2024

Background and Objectives: To evaluate the diagnostic accuracy of widely available biomarkers longitudinally measured throughout pregnancy to predict all and term (delivery at ≥37 weeks) preeclampsia (PE). Materials and Methods: This is a longitudinal retrospective study performed at Hospital Universitario de Torrejón (Madrid, Spain) and Shterev Hospital (Sofia, Bulgaria) between August 2017 and December 2022. All pregnant women with singleton pregnancies and non-malformed live fetuses attending their routine ultrasound examination and first-trimester screening for preterm PE at 11 + 0 to 13 + 6 weeks’ gestation at the participating centers were invited to participate in a larger study for the prediction of pregnancy complications. The dataset was divided into two subsets to develop and validate a joint model of time-to-event outcome and longitudinal data, and to evaluate how the area under the receiving operating characteristic curve (AUROC) evolved with time. Results: 4056 pregnancies were included in the training set (59 all PE, 40 term PE) and 944 in the validation set (23 all PE, 20 term PE). For the joint model and all PE, the AUROC was 0.84 (95% CI 0.73 to 0.94) and the detection rate (DR) for a 10% screening positive rate (SPR) was 56.5 (95% CI 34.5 to 76.8). For term PE, AUROC was 0.80 (95% CI 0.69 to 0.91), and DR for a 10% SPR was 55.0 (95% CI 31.5 to 76.9). The AUROC using only information from the first trimester was 0.50 (95% CI 0.37 to 0.64) and it increased to 0.84 (0.73 to 0.94) when using all information available. Conclusions: Routinely measuring MAP and UtA-PI throughout pregnancy may improve the predictive prediction power for all and term-PE.
Debate on the Morphological Variability of the Lateral Pterygoid Muscle—Discrepancies, Speculations and New Original Anatomical Samples
Authors: Rusu Mugurel Constantin , Toader Corneliu , Tudose Răzvan Costin , Grigoriţă Laura Octavia
Published: November 2024

The lateral pterygoid muscle (LPM), a critical component of the masticatory muscles, typically comprises upper (SLPM) and lower (ILPM) heads. However, it is essential to note that the LPM’s structure is not a constant feature, as the number of bundles and their topography can vary. Moreover, additional heads, such as medial and middle heads, and unique-headed configurations of the LPM have been reported. Several studies have demonstrated the penniform structure of the LPM, which is further supported by its diverse pattern of innervation. Anatomically, the LPM originates from the greater wing and lateral pterygoid plate of the sphenoid bone, with variations in these origins being common. For instance, the presence of a broad lateral pterygoid plate or extensions from it can enlarge the origin area of the LPM. Equally variable are the insertions of the LPM, which can include attachments to the mandibular condyle and the temporomandibular joint disc. In some cases, aberrant LPM bundles may attach to the mandibular condyle outside the mandibular notch. Rarely encountered muscles like the pterygoideus proprius, pterygospinosus, and pterygofacialis further add to the diversity of this muscle. The anatomy of the LPM is subject to modification due to factors like atrophy or hypertrophy. Therefore, it is imperative to recognize that a one-size-fits-all anatomical pattern for the LPM does not exist. Instead, a personalized therapeutic approach should be based on a case-by-case determination of the LPM’s specific anatomical configuration. This nuanced understanding challenges the simplistic view of the LPM and underscores the need for individualized clinical considerations.
Effects of Melting/Casting and Thermal Treatment Surrounding Gas Phase Composition on the Properties of a Low-Alloyed Steel
Authors: Ah-lung Guillaume , Barchid Ayyoube , Boubeker Brahim , Samih Youssef , Alami Jones , Senhaji Sanae Baki , Jacquemin Johan
Published: November 2024

This study aims to provide insights into the experimental conditions used during the melting/casting process and subsequent thermal treatments of low-alloy steels, particularly regarding recycled scrap metals. As sustainable practices in metallurgy gain importance, optimizing scrap metal recycling is crucial for producing steel grades with desired chemical compositions, microstructures, and physical properties. Understanding these conditions is vital for enhancing the efficiency and quality of steel production from recycled materials. This study emphasizes the critical role of specific experimental conditions in the steelmaking process, especially with recycled scrap metals. It closely examines the atmosphere during melting/casting to identify key parameters that must be rigorously controlled in lab-scale steel production using a vacuum induction furnace. The findings indicate that both the chemical composition and recyclability of low-alloyed steels are significantly influenced by the surrounding atmosphere during melting and casting. Inert environments, such as vacuum or argon, are shown to be ideal for steelmaking with induction technology, particularly when recycling scrap metals. Additionally, this study highlights the importance of precise heat treatments, including homogenization and normalization, by controlling both thermal conditions and the atmosphere to produce high-quality steel from recycled scraps.
Unveiling Metabolic Crosstalk: Bacillus-Mediated Defense Priming in Pine Needles Against Pathogen Infection
Authors: Yang Quan , Niu Anqi , Li Shuang , Liu Junang , Zhou Guoying
Published: November 2024

Background/Objectives: Plant growth-promoting rhizobacteria (PGPR), particularly Bacillus spp., are pivotal in enhancing plant defense mechanisms against pathogens. This study aims to investigate the metabolic reprogramming of pine needles induced by Bacillus csuftcsp75 in response to the pathogen Diplodia pinea P9, evaluating its potential as a sustainable biocontrol agent. Methods: Using liquid chromatography–mass spectrometry (LC-MS/MS), we performed a principal component analysis and a cluster analysis to assess the metabolic alterations in treated versus control groups. This study focused on specific metabolites associated with plant defense. Results: Our findings indicate that treatment with Bacillus csuftcsp75 significantly modifies the metabolic profiles of pine needles, leading to notable increases in metabolites associated with flavonoid biosynthesis, particularly phenylpropanoid metabolism, as well as amino acid metabolism pathways. These metabolic changes indicate enhanced systemic acquired resistance (SAR) and induced systemic resistance (ISR), with treated plants exhibiting elevated levels of defense-related compounds such as 5-hydroxytryptophol and oleanolic acid. Conclusions: This study reveals that Bacillus csuftcsp75 enhances defense against pathogen P9 by modulating pine needle metabolism and activating key immune pathways, inducing systemic acquired resistance and induced systemic resistance, offering a natural alternative to chemical pesticides in sustainable agriculture.
Investigation of the Measurement Systems’ Suitability for the Non-Destructive Measurement of Complex Polymer-Based Micro and Nanostructures
Authors: Burkert Selina , Schwörer Lukas , Schubert Tim , Grundmann Jana , Stein David , Heinrich Andreas
Published: November 2024

In the fabrication of optical polymer-based components, such as diffractive gratings and waveguides, high throughput and high precision are required. The non-destructive evaluation of these complex polymer-based structures is a significant challenge. Different measurement techniques can measure the structure geometry directly or via its functionality indirectly. This study investigates various measurement techniques aimed at assessing these structures from 200 nm up to 20 µm. Environmental scanning electron microscopy (ESEM), white light interferometry (WLI), atomic force microscopy (AFM), micro computed tomography (µCT), optical coherence tomography (OCT), phase contrast microscopy (PCM), and Mueller matrix ellipsometry (MME) are investigated for their practical limits of lateral resolution and aspect ratio. The impact of the specimens’ complexity factors, including structure width and aspect ratio, on measurement quality is discussed. A particular focus of this study is on the suitability of different measurement systems for evaluating undercuts and enclosed structures while considering structure size, slant angle, and cover thickness. The aim is to discuss the specific advantages of the individual measurement systems and their application areas in order to be able to quickly select suitable measurement systems for a non-destructive evaluation of polymer-based micro and nanostructures.
Parallel Farby–Perot Interferometers in an Etched Multicore Fiber for Vector Bending Measurements
Authors: Wang Kang , Ji Wei , Xiong Cong , Wang Caoyuan , Qin Yu , Shen Yichun , Xiao Limin
Published: November 2024

Vector bending sensors can be utilized to detect the bending curvature and direction, which is essential for various applications such as structural health monitoring, mechanical deformation measurement, and shape sensing. In this work, we demonstrate a temperature-insensitive vector bending sensor via parallel Farby–Perot interferometers (FPIs) fabricated by etching and splicing a multicore fiber (MCF). The parallel FPIs made in this simple and effective way exhibit significant interferometric visibility with a fringe contrast over 20 dB in the reflection spectra, which is 6 dB larger than the previous MCF-based FPIs. And such a device exhibits a curvature sensitivity of 0.207 nm/m−1 with strong bending-direction discrimination. The curvature magnitude and orientation angle can be reconstructed through the dip wavelength shifts in two off-diagonal outer-core FPIs. The reconstruction results of nine randomly selected pairs of bending magnitudes and directions show that the average relative error of magnitude is ~4.5%, and the average absolute error of orientation angle is less than 2.0°. Furthermore, the proposed bending sensor is temperature-insensitive, with temperature at a lower sensitivity than 10 pm/°C. The fabrication simplicity, high interferometric visibility, compactness, and temperature insensitivity of the device may accelerate MCF-based FPI applications.
Importance of Lactobacilli for Human Health
Authors: Heczko Piotr B. , Giemza Milena , Ponikiewska Weronika , Strus Magdalena
Published: November 2024

As an extraordinarily diverse group of bacteria, lactobacilli are now classified into several genera, many of which still include “Lactobacillus” in their names. Despite their names, this group of lactic acid bacteria comprises microorganisms that are crucial for human health, especially during the early development of the human microbiota and immune system. The interactions between lactobacilli and components of the mucosal immunity lead to its shaping and development, which is possibly considered a prime mover in the advancement of the human immune system. Although much of the evidence backing the pivotal role of lactobacilli in maintaining human health comes from studies on probiotics aiming to elucidate the mechanisms of their functional activities and studies on mucosal immunity in germ-free mice, it is justifiable to extend observations on the properties of the individual probiotic Lactobacillus that are related to health benefits onto other strains sharing common characteristics of the species. In this review, we will discuss the acquisition, presence, and functions of lactobacilli in different human microbiota throughout their whole life, including those arising in the amnion and their interactions with mucosal and immune cells. Examples of immune system modulation by probiotic lactobacilli include their colonic competition for available nutrients, interference with colonization sites, competition for binding sites on gut epithelial cells, bacteriocin production, reduction of colonic pH, and nonspecific stimulation of the immune system.
Factors and Mechanisms Affecting Arsenic Migration in Cultivated Soils Irrigated with Contained Arsenic Brackish Groundwater
Authors: Dai Wenjing , Shi Rongguang , Li Xiaodong , Zhao Zhiqi , Xia Zihan , Li Dongli , Li Yan , Cui Gaoyang , Ding Shiyuan
Published: November 2024

Contained arsenic (As) and unsafe brackish groundwater irrigation can lead to serious As pollution and increase the ecological risk in cultivated soils. However, little is known about how Fe oxides and microbes affect As migration during soil irrigation processes involving arsenic-contaminated brackish groundwater. In this study, the samples (porewater and soil) were collected through the dynamic soil column experiments to explore the As migration process and its effect factors during soil irrigation. The results showed that the As concentration in porewater samples from the topsoil was enriched compared to that in the subsoil, and the main solid As fractions were strongly adsorbed or bound to amorphous and crystalline Fe oxides. The aqueous As concentration and the solid As fractions indicated that reductive dissolution and desorption from amorphous Fe oxides were the primary mechanisms of As release at the topsoil and subsoil, respectively. Meanwhile, Sphingomonas_sp., Microvirga_ossetica and Acidobacteriota_bacterium were the dominant microbes affecting As biotransformation by arsenate reductase gene (arsC) expression. Accompanied by the Eh and competitive ions concentration change, amorphous Fe oxide dissolution increased to facilitate the As release, and the changes in the microbial community structure related to As reduction may have enhanced As mobilization in soils irrigated by As-containing brackish groundwater.
Fabrication of Pb-Containing PtAu Nanoflowers via Galvanic Replacement Method for Electrocatalytical Oxidation of Methanol
Authors: Huang Zhao , Zhang Zhirou , Chao Long , Jia Xueen
Published: November 2024

A Pb-containing PtAu nanoflower electrocatalyst was deposited on the cathode via galvanic replacement reaction in a double-cabin galvanic cell (DCGC) with a Cu plate as the anode, a multiwalled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) as the cathode, 0.1 M HClO4 aqueous solution as the anolyte, and Pb2+-containing Pt4+ salt and Au3+ salt mixed aqueous solution as the catholyte, respectively, and the electrocatalytic performance of the modified electrode toward methanol oxidation in the alkaline medium was investigated. Electrochemical studies reveal that the stripping of bulk Cu can induce underpotential deposition (UPD) of Pb on Pt during the galvanic replacement reaction, which affects the morphology and composition of Pb-containing PtAu nanoparticles. Under the optimal experimental conditions, a Pb-Pt3Au1/MWCNTs/GCE shows the highest activity and the best stability toward electrocatalytic oxidation of methanol in the alkaline medium, and the Pt active area-normalized specific electrocatalytic activity of Pb-Pt3Au1/MWCNTs/GCE is as high as 59.8 mA cmPt−2. We believe that the method presented here of depositing highly active noble metal nanostructures by galvanic replacement reaction in a DCGC device is expected to be widely applied in the preparation of nanomaterials for their study in fuel cells and electrocatalysis.
Structure–Activity Relationship Studies in a Series of 2-Aryloxy-N-(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels
Authors: Mishra Nigam M. , Spitznagel Brittany D. , Du Yu , Mohamed Yasmeen K. , Qin Ying , Weaver C. David , Emmitte Kyle A.
Published: November 2024

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the KCNT1 gene. KCNT1 encodes the sodium-activated potassium channel known as SLACK, making small molecule inhibitors of SLACK channels a compelling approach to the treatment of EIMFS and other epilepsies associated with KCNT1 mutations. In this manuscript, we describe a hit optimization effort executed within a series of 2-aryloxy-N-(pyrimidin-5-yl)acetamides that were identified via a high-throughput screen. We systematically prepared analogs in four distinct regions of the scaffold and evaluated their functional activity in a whole-cell, automated patch clamp (APC) assay to establish structure-activity relationships for wild-type (WT) SLACK inhibition. Two selected analogs were also profiled for selectivity versus other members of the Slo family of potassium channels, of which SLACK is a member, and versus a panel of structurally diverse ion channels. The same two analogs were evaluated for activity versus the WT mouse channel as well as two clinically relevant mutant human channels.
Bioactive Properties of Microencapsulated Anthocyanins from Vaccinium floribundum and Rubus glaucus
Authors: Barba-Ostria Carlos , Gonzalez-Pastor Rebeca , Castillo-Solís Fabián , Carrera-Pacheco Saskya E. , Lopez Orestes , Zúñiga-Miranda Johana , Debut Alexis , Guamán Linda P.
Published: November 2024

Anthocyanins, widely recognized for their antioxidant properties and potential health benefits, are highly susceptible to degradation due to environmental factors such as light, temperature, and pH leading to reduced bioavailability and efficacy. Microencapsulation, which involves entrapment in a matrix to enhance stability and bioavailability. This study aims to investigate the bioactive properties of microencapsulated anthocyanins derived from Vaccinium floribundum (Andean blueberry) and Rubus glaucus (Andean blackberry). The extracts from V. floribundum and R. glaucus were microencapsulated using maltodextrin as the carrier agent due to its film-forming properties and effectiveness in stabilizing sensitive compounds through a spray-drying process. The microcapsules were characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) to assess their chemical and morphological properties. The biological activities of these microencapsulated anthocyanins were evaluated using in vitro assays for their antibacterial, antioxidant, and anti-inflammatory effects. The results indicated enhanced bioactivity of the microencapsulated anthocyanins, suggesting their potential use in developing functional foods and pharmaceuticals. This study provides valuable insights into the effectiveness of microencapsulation in preserving anthocyanins’ functional properties and enhancing their health-promoting effects, highlighting the potential for application in the food and pharmaceutical industries.
Synthesis and Physiochemical Properties of Sulphated Tamarind (Tamarindus indica L.) Seed Polysaccharide
Authors: Ziliani Sabrina , Alekseeva Anna , Antonini Carlo , Esposito Emiliano , Neggiani Fabio , Sansò Marco , Guerrini Marco , Bertini Sabrina
Published: November 2024

Tamarind seed polysaccharide (TSP) is a neutral water-soluble galactoxyloglucan isolated from the seed kernel of Tamarindus indica with average molecular weight (Mw) 600–800 kDa. The high viscosity of TSP slows solubilisation, and the absence of charged substituent hinders the formation of electrostatic interactions with biomolecules. TSP was sulphated in a one-step process using dimethylformamide as a solvent, and sulphur trioxide-pyridine complex as a sulphating reagent. Studies of chemical structure, molecular weight distribution and viscosity were conducted to characterise the synthesised products. The sulphation degree was established by conductimetric titration; the sulphate group distribution was studied by NMR spectroscopy and liquid chromatography-mass spectrometry, and sulphated TSP oligomers were obtained by enzymatic degradation with cellulase and/or xyloglucanase. Sulphated products showed higher solubility than TSP, Mws in the range of 700–1000 kDa, a sulphation degree of two to four per subunit and pseudoplastic behaviour. A preliminary study of mucoadhesion revealed the unexpected interaction of S-TSP with mucin, providing a route by which sulphated TSP interactions with biomolecules may be influenced.
Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein
Authors: Taninaka Atsushi , Kurokawa Hiromi , Kamiyanagi Mayuka , Takeuchi Osamu , Matsui Hirofumi , Shigekawa Hidemi
Published: November 2024

We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction.
TCAD Simulation of Resistive Switching Devices: Impact of ReRAM Configuration on Neuromorphic Computing
Authors: Kim Seonggyeom , Lee Jonghwan
Published: November 2024

This paper presents a method for modeling ReRAM in TCAD and validating its accuracy for neuromorphic systems. The data obtained from TCAD are used to analyze the accuracy of the neuromorphic system. The switching behaviors of ReRAM are implemented using the kinetic Monte Carlo (KMC) approach. Realistic ReRAM characteristics are obtained through the use of the trap-assisted tunneling (TAT) model and thermal equations. HfO2-Al2O3-based ReRAM offers improved switching behaviors compared to HfO2-based ReRAM. The variation in conductance depends on the structure of the ReRAM. The conductance extracted from TCAD is validated in the neuromorphic system using the MNIST (Modified National Institute of Standards and Technology) dataset.
Hydrothermal and Co-Precipitation Combined with Photo-Reduced Preparation of Ag/AgBr/MgBi2O6 Composites for Visible Light Degradation Toward Organics
Authors: Huang Hsin-Yi , Arun Mudakazhi Kanakkithodi , Thomas Sabu , Wu Mei-Yao , Wu Tsunghsueh , Lin Yang-Wei
Published: November 2024

This study developed a MgBi2O6-based photocatalyst via low-temperature hydrothermal synthesis. AgBr was co-precipitated onto MgBi2O6, and silver nanoparticles (AgNPs) were photo-reduced onto the surface. The photocatalytic performance, assessed by methylene blue (MB) degradation under white-light LED irradiation (2.5 W, power density = 0.38 W/cm2), showed that Ag/AgBr/MgBi2O6 achieved 98.6% degradation in 40 min, outperforming MgBi2O6 (37.5%) and AgBr/MgBi2O6 (85.5%). AgNPs boosted electron-hole separation via surface plasmon resonance, reducing recombination. A Z-scheme photocatalytic mechanism was suggested, where photogenerated carriers transferred across the p–n heterojunction between AgBr and MgBi2O6, producing reactive oxygen species like superoxide and hydroxyl radicals critical for dye degradation. Thus, the Ag/AgBr/MgBi2O6 composites possessed excellent photocatalytic performance regarding dyestuff degradation (85.8–99.9% degradation within 40 min) under white-light LED irradiation.
Sensitization and Habituation of Hyper-Excitation to Constant Presentation of Pattern-Glare Stimuli
Authors: Jefferis Thomas , Dogan Cihan , Miller Claire E. , Karathanou Maria , Tempesta Austyn , Schofield Andrew J. , Bowman Howard
Published: November 2024

Background/Objectives: Pattern glare, associated with cortical hyperexcitability, induces visual distortions and discomfort, particularly in individuals susceptible to migraines or epilepsy. While previous research has primarily focused on transient EEG responses to patterned stimuli, this study aims to investigate how continuous presentation of pattern-glare stimuli affects neural adaptation over both fine (seconds) and coarse (entire experiment) temporal scales. Methods: EEG recordings were obtained from 40 healthy participants exposed to horizontal square-wave gratings at three spatial frequencies presented continuously for three seconds each across multiple trials. Participants’ susceptibility to visual stress, headaches, and discomfort was assessed using questionnaires before and during the experiment. The experiment employed a two-by-two design to evaluate habituation (exponentially decreasing response) and sensitisation (exponentially increasing response) effects at two different time granularities. Mass univariate analysis with cluster-based permutation tests was conducted to identify significant brain response changes during the period of constant stimulation, which we call the DC-shift period. Results: Significant effects were observed during the DC-shift period, indicating sustained hyper-excitation to the medium-pattern glare stimulus. In particular, the mean/intercept analysis revealed a consistent positive-going response to the medium stimulus throughout the DC-shift period, suggesting continued neural engagement. Participants reporting higher discomfort exhibited sensitisation at fine temporal granularity and habituation at coarser temporal granularity. These effects were predominantly localised to the right posterior scalp regions. Conclusions: The study demonstrates that individuals sensitive to pattern-glare stimuli exhibit dynamic neural adaptation characterised by short-term sensitisation and long-term habituation. These findings enhance the understanding of cortical hyperexcitability mechanisms and may inform future interventions for visual-stress-related conditions, such as migraines and epilepsy. Further research is needed to explore the underlying neural processes and validate these effects in clinical populations.
Macamides as Potential Therapeutic Agents in Neurological Disorders
Authors: Vera-López Karin J. , Davila-Del-Carpio Gonzalo , Nieto-Montesinos Rita
Published: November 2024

Therapeutic treatment of nervous system disorders has represented one of the significant challenges in medicine for the past several decades. Technological and medical advances have made it possible to recognize different neurological disorders, which has led to more precise identification of potential therapeutic targets, in turn leading to research into developing drugs aimed at these disorders. In this sense, recent years have seen an increase in exploration of the therapeutic effects of various metabolites extracted from Maca (Lepidium meyenii), a plant native to the central alpine region of Peru. Among the most important secondary metabolites contained in this plant are macamides, molecules derived from N-benzylamides of long-chain fatty acids. Macamides have been proposed as active drugs to treat some neurological disorders. Their excellent human tolerance and low toxicity along with neuroprotective, immune-enhancing, and and antioxidant properties make them ideal for exploration as therapeutic agents. In this review, we have compiled information from various studies on macamides, along with theories about the metabolic pathways on which they act.
The Mediating Effect of Eating Behaviors on Interoception, Self-Regulation and Weight Status Among College Students
Authors: Jeune Shanté , Graziano Paulo , Campa Adriana , Coccia Catherine
Published: November 2024

Background/Objectives: Obesity among college students has been consistently high in the recent decades. Regulatory processes such as interoception and self-regulation have been studied to identify specific health behaviors that lead to weight gain. Reduced interoception and self-regulation may lead to increased body mass index (BMI), however, various eating styles may indirectly affect this relationship. It is proposed that poor interoception and self-regulation can increase the incidence of maladaptive eating styles, such as emotional or external eating, which may indirectly contribute to weight gain. Conversely, eating styles like cognitive restraint and intuitive eating may indicate an opposing indirect effect, exhibiting eating behaviors likely to maintain optimal weight status. To date, it is unknown which eating styles mediate the relationship between interoception and self-regulation on BMI. Additionally, study variables were examined throughout time to identify any potential influences throughout a typical semester. Methods: There were 104 female participants who completed the study measures. Participants were primarily identified as Hispanic (75.1%), mean age = 23.39 (SD = 6.312), and mean BMI = 25.45 (SD = 5.48) at baseline. Preliminary statistics and longitudinal mediation analyses were conducted to examine the relationships among eating styles, interoception, self-regulation, and BMI. Results: Intuitive eating was the only eating style that was found to be a significant mediator among both interoception and self-regulation, and BMI. It is theorized that these regulation skills occur more commonly among college females who intuitively eat, thus accurately explaining the associations with BMI. Conclusions: The study has provided foundational evidence on the indirect effect of eating behaviors on one’s relationship with interoception and self-regulation on BMI and can be useful in future interventions regarding college students and their associated risk for obesity.
Correlates of Overweight and Obesity in German Primary School Children
Authors: Reißner Anna , Wartha Olivia , Dreyhaupt Jens , Kobel Susanne
Published: November 2024

Background/Objectives: Childhood obesity is a consistent public health issue, which often persists into adulthood. This study determined risk factors of childhood obesity and associated comorbidities in German school children. Methods: Data of 1956 primary school children (7.1 ± 0.6 years) were analysed. Anthropometrics were taken on site, other (health) parameters were assessed using a parental questionnaire. Binary logistic regression models were calculated, controlling for age, gender, family education level, and migration background. Results: Father’s physical illness (OR 1.092 [1.177; 3.073], p = 0.009) and a child’s chronic illness (OR 1.687 [1.077; 2.644], p = 0.022), maternal and paternal overweight (OR 2.180 [1.492; 3.185]; OR 2.494 [1.547; 4.022], p < 0.001, respectively), as well as maternal and paternal smoking (OR 1.942 [1.306; 2.889]; OR 1.972 [1.334; 2.917], p = 0.001, respectively) were significantly associated with the child being overweight. Also associated with the child being overweight were physical activity, regular screen media use (OR 0.605 [0.408, 0.896], p = 0.012; OR 2.029 [1.306; 3.152], p = 0.002, respectively), the mother and/or father thinking their child is too fat (OR 2.213 [1.504; 3.258], p < 0.001; OR 1.537 [1.048; 2.253], p = 0.028), the father’s physical inactivity (OR 1.69 [1.133; 2.521], p = 0.010), and if the child has not been breastfed (OR 1.632 [1.056; 2.521], p = 0.027), the mother smoked during pregnancy (OR 1.992 [1.224; 3.246], p = 0.006) as well as if the mother and/or father admonished their child about their weight (OR 25.521 [14.578; 44.680]; OR 19.448 [11.865; 31.877], p < 0.001, respectively). Children of unemployed mothers and in low-income households had an increased risk of being overweight (OR 4.811 [1.642; 14.096], p = 0.004; OR 2.203 [1.360; 3.568], p = 0.001, respectively). Conclusions: This study shows that parental health, lifestyle, and social behaviours matter in determining childhood obesity. Understanding those is essential to promoting a healthy lifestyle.
Dietary and Nutritional Interventions for the Management of Endometriosis
Authors: Abulughod Nour , Valakas Stefanie , El-Assaad Fatima
Published: November 2024

Endometriosis is a chronic, complex, systemic inflammatory condition that impacts approximately 190 million girls and women worldwide, significantly impacting their quality of life. The effective management of endometriosis requires a multi-disciplinary and holistic approach, one that includes surgical and medical management, such as a laparoscopy and a chronic medical management plan, as well as dietary, nutritional, and lifestyle adjunct interventions, such as pelvic pain physiotherapy and acupuncture. There is growing evidence to support the role of dietary and nutritional interventions in the adjunct management of endometriosis-related pain and gastrointestinal symptoms. However, the implementation of these interventions is often not regulated, as patients with endometriosis often adopt self-management strategies. Diet and nutrition can modulate key players integral to the pathophysiology of endometriosis, such as, but not limited to, inflammation, estrogen, and the microbiome. However, it is unclear as to whether diet plays a role in the prevention or the onset of endometriosis. In this review, we discuss three key players in the pathogenesis of endometriosis—inflammation, estrogen, and the microbiome—and we summarize how diet and nutrition can influence their mechanisms, and consequently, the progression and manifestation of endometriosis. There is a major need for evidence-based, non-invasive adjunct management of this debilitating disease, and diet and nutritional interventions may be suitable.
Designing Front-of-Package Labels to Inform Consumers and Encourage Healthier Food Choices in Bangladesh: A Qualitative Study
Authors: Taillie Lindsey Smith , Abrar Ahmad Khairul , Afroza Ummay , Akhtar Jubaida , Noe Violet , Ide Nicole , Abdel-Gawad Nora , Choudhury Sohel Reza
Published: November 2024

Background/Objectives: Front-of-package labeling (FOPL) policies are a useful strategy to inform consumers about foods high in nutrients of concern, but little is known about what type of label works best in Bangladesh, a country with increasing levels of unhealthy food intake and diet-related diseases. Methods: We conducted 10 focus groups with men and women in rural and urban Bangladesh (n = 76). Using a semi-structured discussion guide, we asked consumers for their perceptions of the healthfulness of nutrients and foods, two common FOPLs (a color-coded guideline daily allowance [GDA] label and a warning label), and different visual elements of the warning label (e.g., shape, icon, text). Results: Participants understood the health harms of sugar and salt consumption but were less clear on saturated fat. Both FOPLs were perceived as helpful for identifying unhealthy foods, but the warning labels were perceived as easier to understand and more likely to influence behaviors than the GDA. Regarding the design of warning labels, participants perceived warning devices, holding straps, and octagonal shapes as effective but had mixed reactions to which icons or textual statements were most effective. Conclusions: FOPLs are likely to facilitate Bangladeshi consumers’ ability to identify unhealthy products. Further research is needed to understand the impact on food choices as well as the most effective design in this population.
Electronic Nursing Records: Importance for Nursing and Benefits of Implementation in Health Information Systems—A Scoping Review
Authors: Taneva Daniela Ivova , Gyurova-Kancheva Vasilka Todorova , Kirkova-Bogdanova Angelina Georgieva , Paskaleva Diana Angelova , Zlatanova Yovka Tinkova
Published: November 2024

Introduction: The advancement of nursing science and practice necessitates the documentation of information, which is increasingly being recorded in electronic mediums due to the progress of information technology. Various countries around the world have implemented electronic nursing records (ENRs) or are in the process of implementing them. This study aims to ascertain the significance of electronic nursing records and consolidate their primary benefits for nursing. Methods: The study utilized an established scoping review methodology (Arksey and O‘Malley protocol; JBI method; PRISMA ScR (2018)). Results: Out of 6970 initial articles extracted from four databases, 36 were included in the study. Several essential elements for structuring, introducing, and emphasizing the importance of ENRs have been recognized, including the availability of standardized terminology, enhancement of nursing care quality, advancement of research activity, integration with electronic systems, optimization of healthcare, and conditions for ENR integration. Conclusions: Electronic nursing records are indispensable and beneficial for enhancing care quality, improving patient safety, and affirming the autonomy of the nursing profession.
Dynamic Excitation of Surface Plasmon Polaritons with Vector Laguerre–Gaussian Beams
Authors: Peña-Ramírez Aldo , Zhai Tingting , Salas-Montiel Rafael , Ruiz-Cortés Víctor
Published: November 2024

We investigate the dynamic excitation of surface plasmon polaritons (SPPs) using vector Laguerre–Gauss (LG) beams, which offer unique properties for manipulating the polarization and spatial distribution of light. Our study demonstrates the efficient coupling of SPPs with LG beams, characterized by their azimuthal and radial indices (m,p), as well as polarization distribution type. Numerical simulations reveal that the vector nature of LG beams enables selective excitation of SPPs, depending on the polarization type of the beam. Experimental verification of our simulations is achieved using a gold circular Bragg grating and a spatial light modulator that generates vector LG beams. Leakage radiation imaging demonstrates the potential of vector LG beams for dynamic SPP excitation and manipulation. This study opens novel ways for the control of SPPs in plasmonic devices, such as modulators, and nanophotonic circuits.