bluuebunny/crossref_metadata_2025 huggingface dataset:
Families Affected by Parental Cancer: Quality of Life, Impact on Children and Psychosocial Care Needs
Authors: Inhestern Laura , Johannsen Lene Marie , Bergelt Corinna
Published: November 2021

Parental cancer poses major challenges for families with minor children. Due to diagnosis and treatment family life is disrupted. To prevent long-term consequences in all family members and to design needs-oriented family-centered interventions, further understanding of the family's situation including the impact on the children, quality of life levels and the parental psychosocial needs is necessary. This study aims at investigating the impact of parental cancer on the minor children, family-specific psychosocial needs and quality of life levels of parents and children. Cancer patients parenting at least 1 minor child (<18 years) were eligible for study participation. In total, n=86 cancer patients under treatment participated in the study. After excluding participants without a minor child, 78 patients remained for analyses. We assessed children's quality of life using the parent proxy version of the KIDSCREEN-10 and parental quality of life using the EORTC QLQ C30 quality of life questionnaire. Additionally, the questionnaire comprised open questions about positive and negative changes parents perceived in their children as well as questions on specific family- and child-related psychosocial needs. The majority of participants were mothers (91%), mainly diagnosed with breast cancer (59%). The participating parents provided data on 117 minor children. Parents mentioned positive changes in 38% of the children (e.g., being more attentive and helpful). Negative changes were reported in 37% of the children (e.g., being more anxious and clingy). Parents reported family-specific psychosocial supportive care needs for themselves as a parent (e.g., support regarding parenting concerns), support needs for the partner or the children. Moreover, parents expressed family-related information needs and needs regarding practical aspects (e.g., childcare, household help). Global quality of life was M = 55.7 (SD = 23.4) for parents and M = 57.5 (SD = 15.5) for children. Pearson's correlation coefficient between parental and children's quality of life was 0.377 (p < 0.001). To identify parents with cancer and children in need for additional support, health care providers should proactively inquire about the impact of the disease on the children. In terms of a comprehensive cancer care, the direct assessment of family impact and family-specific support needs in cancer patients with minor children allows for needs-based allocation to support offers.
Impact of Catastrophic Health Expenditures on Chinese Household Consumption
Authors: Wei Ning , Huang Wenhao , Zhou Lü-lin
Published: November 2021

China has built a social medical insurance system that covers the entire population so as to reduce the impact of diseases on individuals and families. Although the decline in the incidence of catastrophic health expenditures (CHEs) in China is encouraging, this issue remains important. On the basis of considering selectivity bias and heterogeneity, we applied propensity score matching (PSM) to analyze the 2018 data from the China Family Panel Studies. We assigned CHE households and non-CHE households to the treatment group and the control group, respectively, and used non-random data to simulate a randomized trial to investigate the impact of CHE on household consumption in China. The results of this study indicate that, when the threshold is set at 40%, the consumption of households experiencing CHEs (CHE household) is significantly lower than that of households not experiencing CHEs (non-CHE households) and that CHEs have a significant negative impact on other household consumption and a significant impact on the household property and debt. This effect still exists when the threshold is set lower, with household essential consumption most affected. The occurrence of CHEs leads to a reduction in household consumption and a significantly worsening financial situation for the CHE households, impacting the basic quality of life of the families. Therefore, it is necessary to further reform the medical and health system to reduce the high medical expenses.
Training LEADers to Accelerate Global Mental Health Disparities Research (LEAD) Program: A Research Training Program Protocol
Authors: Sensoy Bahar Ozge , Cavazos-Rehg Patricia , Ssewamala Fred M. , Abente Betsy , Peer Laura , Nabunya Proscovia , Soto de Laurido Lourdes E. , Betancourt Theresa S. , Bhana Arvin , Edmond Tonya
Published: November 2021

Background:There is a critical need to address mental health needs across the globe, especially in low and middle-income countries where mental health disparities are pervasive, including among children. The global mental health disparities suggest an imperative for culturally and contextually-congruent mental health services models that expand upon the existing services and interventions for these groups. Rigorous research is a key tool in providing the scientific evidence to inform public policy and practice efforts to effectively address these needs. Yet, there is a limited number of researchers, especially those from diverse backgrounds, who study these issues. In this paper, we describe the “TrainingLEADers to Accelerate Global Mental Health Disparities Research”(LEAD) program, a research training program funded by the National Institute on Minority Health and Health Disparities and focused on global mental health disparities research for early career researchers from under-represented minority groups.

Methods:The LEAD program is designed as a two-phase training program for advanced pre-doctoral students, postdoctoral fellows, and junior faculty from diverse backgrounds in the U.S., including groups underrepresented in biomedical, behavioral, clinical and social sciences research, interested in global mental health disparities research. Trainees are matched with mentors and participate in an intensive 12-week program.

Discussion:The LEAD program seeks to provide a robust platform for the development, implementation and expansion of evidence-based culturally and contextually-congruent interventions and services models addressing global mental health disparities across the life cycle, especially in low-resource communities in the global context. By producing a sustainable network of well-trained investigators from underrepresented backgrounds, LEAD will potentially contribute to the shared lessons and efforts relevant to addressing global mental health disparities and improving care for vulnerable populations in low-resource settings.
Public Health Measures During the COVID-19 Pandemic Reduce the Spread of Other Respiratory Infectious Diseases
Authors: Hu Cheng-yi , Tang Yu-wen , Su Qi-min , Lei Yi , Cui Wen-shuai , Zhang Yan-yan , Zhou Yan , Li Xin-yan , Wang Zhong-fang , Zhao Zhu-xiang
Published: November 2021

Background: Public health measures (such as wearing masks, physical distancing, and isolation) have significantly reduced the spread of the coronavirus disease-2019 (COVID-19), but the impact of public health measures on other respiratory infectious diseases is unclear.

Objective: To assess the correlation between public health measures and the incidence of respiratory infectious diseases in China during the COVID-19 pandemic.

Methods: We collected the data from the National Health and Construction Commission in China on the number of patients with six respiratory infectious diseases (measles, tuberculosis, pertussis, scarlet fever, influenza, and mumps) from 2017 to 2020 and assessed the correlation between public health measures and the incidence of respiratory infectious diseases. Finally, we used the data of the six respiratory infectious diseases in 2021 to verify our results.

Results: We found public health measures significantly reduced the incidence of measles (p = 0.002), tuberculosis (p = 0.002), pertussis (p = 0.004), scarlet fever (p = 0.002), influenza (p = 0.034), and mumps (p = 0.002) in 2020, and prevented seasonal peaks. Moreover, the effects of public health measures were most marked during the peak seasons for these infections. Of the six respiratory infectious diseases considered, tuberculosis was least affected by public health measures.

Conclusion: Public health measures were very effective in reducing the incidence of respiratory infectious diseases, especially when the respiratory infectious diseases would normally have been at their peak.
Neodymium Isotope Geochemistry of a Subterranean Estuary
Authors: Chevis Darren A. , Mohajerin T. Jade , Yang Ningfang , Cable Jaye E. , Rasbury E. Troy , Hemming Sidney R. , Burdige David J. , Martin Jonathan B. , White Christopher D. , Johannesson Karen H.
Published: November 2021

Rare earth elements (REE) and Nd isotope compositions of surface and groundwaters from the Indian River Lagoon in Florida were measured to investigate the influence of submarine groundwater discharge (SGD) on these parameters in coastal waters. The Nd flux of the terrestrial component of SGD is around 0.7±0.03 μmol Nd/day per m of shoreline across the nearshore seepage face of the subterranean estuary. This translates to a terrestrial SGD Nd flux of 4±0.2 mmol/day for the entire 5,880 m long shoreline of the studied portion of the lagoon. The Nd flux from bioirrigation across the nearshore seepage face is 1±0.05 μmol Nd/day per m of shoreline, or 6±0.3 mmol/day for the entire shoreline. The combination of these two SGD fluxes is the same as the local, effective river water flux of Nd to the lagoon of 12.7±5.3 mmol/day. Using a similar approach, the marine-sourced SGD flux of Nd is 31.4±1.6 μmol Nd/day per m of shoreline, or 184±9.2 mmol/day for the investigated portion of the lagoon, which is 45 times higher than the terrestrial SGD Nd flux. Terrestrial-sourced SGD has an εNd(0) value of −5±0.42, which is similar to carbonate rocks (i.e., Ocala Limestone) from the Upper Floridan Aquifer (−5.6), but more radiogenic than the recirculated marine SGD, for which εNd(0) is −7±0.24. Marine SGD has a Nd isotope composition that is identical to the εNd(0) of Fe(III) oxide/oxyhydroxide coated sands of the surficial aquifer (−7.15±0.24 and −6.98±0.36). These secondary Fe(III) oxides/oxyhydroxides formed during subaerial weathering when sea level was substantially lower during the last glacial maximum. Subsequent flooding of these surficial sands by rising sea level followed by reductive dissolution of the Fe(III) oxide/oxyhydroxide coatings can explain the Nd isotope composition of the marine SGD component. Surficial waters of the Indian River Lagoon have an εNd(0) of −6.47±0.32, and are a mixture of terrestrial and marine SGD components, as well as the local rivers (−8.63 and −8.14). Nonetheless, the chief Nd source is marine SGD that has reacted with Fe(III) oxide/oxyhydroxide coatings on the surficial aquifer sands of the subterranean estuary.
Supplemental Food Production With Plants: A Review of NASA Research
Authors: Johnson Christina M. , Boles Haley O. , Spencer LaShelle E. , Poulet Lucie , Romeyn Matthew , Bunchek Jess M. , Fritsche Ralph , Massa Gioia D. , O’Rourke Aubrie , Wheeler Raymond M.
Published: November 2021

Bioregenerative life-support systems for space have been investigated for 60 years, and plants and other photosynthetic organisms are central to this concept for their ability to produce food and O2, remove CO2, and help recycle wastewater. Many of the studies targeted larger scale systems that might be used for planetary surface missions, with estimates ranging from about 40 to 50 m2(or more) of crop growing area needed per person. But early space missions will not have these volumes available for crop growth. How can plants be used in the interim, where perhaps <5 m2of growing area might be available? One option is to grow plants as supplemental, fresh foods. This could improve the quality and diversity of the meals on the International Space Station or on the Lunar surface, and supply important nutrients to the astronauts for missions like Mars transit, and longer duration Martian surface missions. Although plant chambers for supplemental food production would be relatively small, they could provide the bioregenerative research community with platforms for testing different crops in a space environment and serve as a stepping stone to build larger bioregenerative systems for future missions. Here we review some of NASA’s research and development (ground and spaceflight) targeting fresh food production systems for space. We encourage readers to also look into the extensive work by other space agencies and universities around the world on this same topic.
Research on Applications of Transurethral Plasmakinetic Enucleation of the Prostate in Elderly Patients Aged ≥80 Years
Authors: Su Wen , Yi Ye , Zeng Liang , Tang Jin
Published: November 2021

Objective: To evaluate the safety and efficacy of transurethral plasmakinetic enucleation of the prostate (PKERP) vs. transurethral resection of the prostate (TURP) in elderly patients aged ≥80 years with benign prostate hyperplasia.

Materials and Methods: We conducted a retrospective analysis of the PKERP (n = 123) and TURP (n = 143) in patients aged ≥80 years at urology department of The Third Xiangya Hospital of Central South University from January 2016 to October 2019. Then the preoperative, intraoperative, and postoperative data of different indicators were compared between the two groups. The follow-up was done at 3 months, 1 year after surgical treatment.

Results: No significant differences were observed between the two groups for the baseline characteristics, including age, prostate volume, prostate-specific antigen (PSA) level, concurrent disease, maximum urinary flow rate (MFR), international prostate symptoms score (IPSS), and quality of life (QoL) score. The operative time, hemoglobin decrease, and postoperative flushing time were significantly lower in the PKERP group compared with the TURP group. However, no significant differences were observed between both groups for postoperative hospital stay, incidence of transurethral resection syndrome (TURS), prostatic capsular perforation, and genuine urinary incontinence. The follow-up results showed that the MFR of the PKERP group was significantly higher than the TURP group at 1 year after surgery.

Conclusion: Compared with TURP, PKERP is a safe and efficacious method for treating patients aged ≥80 years with benign prostate hyperplasia, and it may improve long-term urination symptoms.
Social Workers in Animal Shelters: A Strategy Toward Reducing Occupational Stress Among Animal Shelter Workers
Authors: Hoy-Gerlach Janet , Ojha Mamta , Arkow Phil
Published: November 2021

Animal shelter workers (ASWs) are at disproportionate risk of moral injury, secondary trauma, compassion fatigue, and burn-out. While there is an emerging body of literature developing on understanding the nuances of these experiences for ASWs, little work has been done on developing strategies to ameliorate occupational stressors and the negative effects of such for ASWs. Within this paper, occupational risks and protective factors for ASWs are summarized, and the emergence of social work within animal shelter settings as one strategy for helping to ameliorate the occupational stress experienced by ASWs is delineated.
Case Report: Spinal Stabilization Surgery Using a Novel Custom-Made Titanium Fixation System for the Spinal Instability Caused by Vertebral Malformation in a Dog
Authors: Kimura Shintaro , Nakata Kohei , Nakano Yukiko , Nozue Yuta , Konno Naoyuki , Sugawara Taku , Maeda Sadatoshi , Kamishina Hiroaki
Published: November 2021

A 2-year-old Maltese was presented with wobbly gait of the pelvic limbs. Based on imaging examinations, a diagnosis of congenital malformation at T5–T8 and severe kyphosis causing spinal cord compression at T6–T7 was made. Dorsal laminectomy and stabilization of T6 and T7 vertebrae were performed. As the size of the vertebrae was small and they were severely deformed, novel custom-made titanium implants were used for spinal stabilization. Clinical signs were resolved 2 weeks after surgery. Although radiographic examination 373 days after surgery showed slight loosening of implants, post-operative course remained uneventful. This report describes the use of novel custom-made titanium implants for spinal fixation surgery in a dog.
Impact of Chinese and European Airspace Constraints on Trajectory Optimization
Authors: Rosenow Judith , Chen Gong , Fricke Hartmut , Sun Xiaoqian , Wang Yanjun
Published: November 2021

Air traffic trajectory optimization is a complex, multidimensional and non-linear optimization problem and requires a firm focus on the essential criteria. The criteria cover operational, economical, environmental, political, and social factors and differ from continent to continent. Since air traffic is a transcontinental transport system, the criteria may also change during a single flight. Historic flight track data allow observation and assess real flights, to extract essential criteria and to derive optimization strategies to increase air traffic efficiency. Real flight track data from the Chinese and European air traffic show significant differences in the routing structure in both regions. For that reason, reference trajectories of historic ADS-B 24-h air traffic data in China and Europe have been extracted and analyzed regarding horizontal flight efficiency and the most restrictive criteria of trajectory optimization. We found that prohibited areas might be the most powerful reason to describe deviations from the great circle distance in the Chinese air traffic system. Atmospheric conditions, network requirements, aircraft types and flight planning procedures are similar in China and Europe and only have a minor impact on flight efficiency during the cruise phase. In a multi-criteria trajectory optimization of the extracted reference trajectories considering the weather, operational constraints and prohibited areas, we found that flown ground distances could be reduced by 255 km in the Chinese airspace and 2.3 km in the European airspace. The resultant reference trajectories can be used for further analysis to increase the efficiency of continental air traffic flows.
Identification and Regionalization of Cold Resistance of Wine Grape Germplasms (V. vinifera)
Authors: Wang Zhilei , Wang Ying , Wu Dong , Hui Miao , Han Xing , Xue Tingting , Yao Fei , Gao Feifei , Cao Xiao , Li Hua , Wang Hua
Published: November 2021

With the extreme changes of the global climate, winter freezing injury has become an important limiting factor for the development of the global grape industry. Therefore, there is a significant need for the screening of cold-resistant wine grape germplasms and cold regionalization for cold-resistant breeding and the development of grapevine cultivation in cold regions. In this study, the low-temperature half-lethal temperature (LT50) values were determined for the annual dormant branches of 124 wine grape germplasms (V. vinifera) to evaluate their cold resistance. The LT50 values of the 124 tested germplasms ranged from −22.01 °C to −13.18 °C, with six cold-resistant germplasms below −20 °C. Based on the LT50 values, the 124 germplasms were clustered into four types, with cold resistance from strong to weak in the order of type Ⅱ > type Ⅰ > type Ⅳ > type Ⅲ, corresponding to the four cold hardiness zones. Zones 1, 2, 3, and 4 included 6, 22, 68, and 28 germplasms, respectively, with decreasing cold resistance. The number of germplasms in different hardiness zones followed a normal distribution, with the most in zone 3. In Type Ⅱ, the fruit skin color of germplasms was positively correlated with cold hardiness, while the temperature of origin was negatively correlated with cold hardiness. The average LT50 of germplasms in different origin regions ranged from −17.44 °C to −16.26 °C, with differences among some regions. The cold regionalization analysis resulted in the distribution of 124 germplasms in four temperature regions in China with six germplasms in region A (−22 °C ≤ LT50 ≤ −20 °C), 30 germplasms in region B (−20°C ≤ LT50 ≤ −18°C), 71 germplasms in region C (−18 °C ≤ LT50 ≤ −15 °C), and 17 germplasms in region D (−15 °C ≤ LT50 ≤ −13 °C). Strong cold-resistant wine grape germplasms (V. vinifera) were identified, and these could be used as parental material for cold-resistant breeding. In some areas in China, soil-burial over-wintering strategies are used, but our results suggest that some wine grapes could be cultivated without requiring winter burial during overwintering. The results of this study should provide guidance for the selection of promising strains for cold-resistant breeding for expanded cultivation of improved varieties for wine grape production in China.
Nutrient Accumulation Affected by Corn Stover Management Associated with Nitrogen and Phosphorus Fertilization
Authors: Galindo Fernando Shintate , Strock Jeffrey S. , Pagliari Paulo Humberto
Published: November 2021

Bio-ethanol production from corn stover harvest would change nutrient removal, in particular nitrogen (N) and phosphorus (P), affecting nutrient replenishment and corn development under field-grown conditions. This research was developed to investigate whether stover removal had any influence on the amount of N and P fertilizer required for maximum corn production in the United States (US) Midwest in a stover removal scenario. This study was conducted in Lamberton, MN on a Typic Endoaquoll under continuous corn from 2013 to 2015. The treatments included six N rates (0 to 200 kg N ha−1 in 40 kg increments), five P rates (0 to 100 kg P2O5 ha−1 in 25 kg increments), and two residue management strategies (residue removed or incorporated). Residue management was found to have a significant impact on corn response to N and P application. We verified that residue-removed plots yielded more and therefore required more N and P application from fertilizers. Grain yield after residue was removed was greatest with the highest N and P2O5 rates, whereas grain yield after residue was incorporated was greatest with intermediate N and P2O5 rates in 2013 and 2014. In 2015, residue management did not significantly affect grain yield. Grain N and P accumulation followed a similar behavior as that observed for grain yield. In general, residue removal decreased nutrient availability, while in the residue-incorporated treatment, those nutrients were returned. Although the results of the study showed potential for biomass harvest, it also indicated that nitrogen immobilization and nutrient depletion from the soil could be a limiting factor.
Molecular Detection of Infectious Laryngotracheitis Virus in Chickens with a Microfluidic Chip
Authors: El-Tholoth Mohamed , Bai Huiwen , Mauk Michael G. , Anis Eman , Bau Haim H.
Published: November 2021

Infectious laryngotracheitis (ILT) is a viral disease of chickens’ respiratory system that imposes considerable financial burdens on the chicken industry. Rapid, simple, and specific detection of this virus is crucial to enable proper control measures. Polymerase chain reaction (PCR)-based molecular tests require relatively expensive instruments and skilled personnel, confining their application to centralized laboratories. To enable chicken farms to take timely action and contain the spread of infection, we describe a rapid, simple, semi-quantitative benchtop isothermal amplification (LAMP) assay, and a field-deployable microfluidic device for the diagnosis of ILTV infection in chickens. Our assay performance was compared and favorably agreed with quantitative PCR (qPCR). The sensitivity of our real-time LAMP test is 250 genomic copies/reaction. Clinical performance of our microfluidic device using samples from diseased chickens showed 100% specificity and 100% sensitivity in comparison with benchtop LAMP assay and the gold-standard qPCR. Our method facilitates simple, specific, and rapid molecular ILTV detection in low-resource veterinary diagnostic laboratories and can be used for field molecular diagnosis of suspected ILT cases.
Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
Authors: Riahi Insaf , Ramos Antonio J. , Raj Jog , Jakovčević Zdenka , Farkaš Hunor , Vasiljević Marko , Pérez-Vendrell Anna Maria
Published: November 2021

The present study was conducted to evaluate the efficacy of the feed additive, a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae cell walls, and silymarin, as detoxifiers of 0.5 mg/kg (0.5 ppm) ochratoxin A (OTA) and 1 mg/kg (1 ppm) T-2 toxin on broiler chickens. A total of 240 1-old broiler chickens (Ross 308) were randomly distributed into five different dietary treatments: (1) control (non-contaminated diet); (2) non contaminated diet + 3 g/kg of MMDA; (3) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin; (4) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 1 g/kg MMDA; and (5) non-contaminated diet + 0.5 mg/kg OTA + 1 g/kg T-2 toxin + 3 g/kg MMDA. The results showed that, in the starter period, from 1 to 10 days, the presence of OTA and T-2 mycotoxins reduced the consumption of feed and the growth of the broilers, and no effects of the detoxifying product were observed in the productivity of the chickens, at any of the doses tested, compared to the contaminated control (treatment 3). However, in the growing period, the same negative effect of mycotoxins was registered, but a recovery was observed in the consumption of feed and in the weight of the broilers that consumed 3 g/kg of the MMDA mycotoxin binder, reaching similar values to those of chickens fed uncontaminated control diets. The presence of mycotoxins in feed led to a reduction in the concentration of total proteins and albumin in blood compared to controls, and the presence of the detoxifying product partially reversed this effect. The breast yield of the chickens fed with mycotoxins was lower than that of the animals fed with the control feed and was not affected by the presence of the product tested, at 1 or 3 g/kg. The weight of the different organs (liver, gizzard, kidneys, or spleen), the intestinal pH, the histology of the small intestine, and oral lesions were not affected by the experimental treatments. In summary, the productive parameters and some blood and carcass characteristics of broiler chickens were impaired by the dietary presence of OTA and T-2 toxin. The tested product included at 1 or 3 g/kg feed in contaminated diets improved performance and seems to be effective in partly counteracting the deleterious effects of the tested mycotoxins.
The Use of Genomic Information for the Conservation of Animal Genetic Diversity
Authors: Oldenbroek J. Kor
Published: November 2021

The conservation of genetic diversity, both among and within breeds, is a costly process. Therefore, choices between breeds and animals within breeds are unavoidable, either for conservation in vitro (gene banks) or in vivo (maintaining small populations alive). Nowadays, genomic information on breeds and individual animals is the standard for the choices to be made in conservation. Genomics may accurately measure the genetic distances among breeds and the relationships among animals within breeds. Homozygosity at loci and at parts of chromosomes is used to measure inbreeding. In addition, genomics can be used to detect potentially valuable rare alleles and haplotypes, their carriers in these breeds and can facilitate in vivo or in vitro conservations of these genomic regions.
Effects of Dietary Perilla Cake Supplementation in Growing Pig on Productive Performance, Meat Quality, and Fatty Acid Profiles
Authors: Arjin Chaiwat , Souphannavong Chanmany , Norkeaw Rakkiat , Chaiwang Niraporn , Mekchay Supamit , Sartsook Apinya , Thongkham Maninphan , Yosen Thanchanok , Ruksiriwanich Warintorn , Sommano Sarana Rose , Sringarm Korawan
Published: November 2021

The objective of this study was to determine the effect of perilla cake (PC) supplementation in a growing pig diet on overall growing performance, meat quality, and fatty acid profile. A total of 24 barrow grower crossbred pigs (Large White × Landrace) × Duroc with an initial average body weight of 26.33 kg were fed with a basal diet supplemented with PC at 0%, 5%, and 10% in (PC0, PC5, and PC10, respectively) for 12 weeks. At the end of the experimental period, pigs were slaughtered to determine carcass traits and meat quality. Back fat, abdominal fat, and longissimus dorsi (LD) muscle were collected to investigate fatty acid composition. The results show that the average daily gain (ADG) in the PC10 significantly increased. However, PC supplementation did not influence carcass traits and meat quality except the color as described by lightness (L*). Dietary PC supplementation significantly increased the α-linolenic acid (ALA, C18:3 cis-9, 12, 15), whereas n6/n3 ratio decreased significantly in all tissues investigated. Thus, it can be concluded that the supplementation of PC in growing pig diet is a potential way to increase the fatty acid composition to that required for healthier meat.
Horses’ Use of Lying Halls and Time Budget in Relation to Available Lying Area
Authors: Kjellberg Linda , Yngvesson Jenny , Sassner Hanna , Morgan Karin
Published: November 2021

Sleep is crucial to horses’ wellbeing, and their lying time can vary according to such factors as climate, exercise, bedding, and housing. This study aimed to analyze behavior and time spent in lying halls of various sizes. We examined the influence of housing systems on total lying time and behavior, and how changes to available lying area can affect lying time. Two open barns were used in this study, with lying areas of 8, 15, and 18 m2/horse available in the lying halls. The horses’ behavior was video recorded and logged using scan sampling and interval observations. Individual boxes were used as a control. The horses were found to spend longer time in sternal and lateral recumbency in the hall with a lying area of 18 m2/horse than the hall with a lying area of 8 m2/horse. Increasing the area of the lying hall also increased overall time spent there. Consequently, the hypothesis that increasing lying area will increase the horses’ use of the lying hall, as well as their total lying time, was accepted.
Identified Seaweed Compound Diphenylmethane Serves as an Efflux Pump Inhibitor in Drug-Resistant Escherichia coli
Authors: Lu Wen-Jung , Hsu Pang-Hung , Chang Chun-Ju , Su Cheng-Kuan , Huang Yan-Jyun , Lin Hsuan-Ju , Lai Margaret , Ooi Gui-Xia , Dai Jing-Yi , Lin Hong-Ting Victor
Published: November 2021

Drug efflux pumps are one of the major elements used by antibiotic-resistant bacteria. Efflux pump inhibitors (EPIs) are potential therapeutic agents for adjunctive therapy, which can restore the activity of antibiotics that are no longer effective against pathogens. This study evaluated the seaweed compound diphenylmethane (DPM) for its EPI activity. The IC50 and modulation results showed that DPM has no antibacterial activity but can potentiate the activity of antibiotics against drug-resistant E. coli. Time-kill studies reported that a combination of DPM and erythromycin exhibited greater inhibitory activity against drug-resistant Escherichia coli. Dye accumulation and dye efflux studies using Hoechst 33342 and ethidium bromide showed that the addition of DPM significantly increased dye accumulation and reduced dye efflux in drug-resistant E. coli, suggesting its interference with dye translocation by an efflux pump. Using MALDI-TOF, it was observed that the addition of DPM could continuously reduce antibiotic efflux in drug-resistant E. coli. Additionally, DPM did not seem to damage the E. coli membranes, and the cell toxicity test showed that it features mild human-cell toxicity. In conclusion, these findings showed that DPM could serve as a potential EPI for drug-resistant E. coli.
Dietary Fiber Intake May Influence the Impact of FTO Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
Authors: Czajkowski Przemyslaw , Adamska-Patruno Edyta , Bauer Witold , Krasowska Urszula , Fiedorczuk Joanna , Moroz Monika , Gorska Maria , Kretowski Adam
Published: November 2021

Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (FTO) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber intake on the obesity-related parameters and lipid profile in the Polish population. We selected 819 Polish Caucasian adult subjects (52.5% female and 47.5% male) for a final gene–diet interaction analysis, with mean BMI 28.5 (±6.6) kg/m2. We performed measurements of anthropometric parameters, total body fat content and distribution, and blood glucose, insulin, and lipid concentrations. Daily fiber intake was analyzed based on 3-day food-intake diaries, and daily physical activity was evaluated based on the International Physical Activity Questionnaire—Long Form. Our study shows that carriers of the GG genotype (rs3751812), CC genotype (rs8050136), and GG genotype (rs6499640) presented lower hip circumference if daily fiber intake was above 18 g per day. Additionally, GG genotype (rs3751812) and CC genotype (rs8050136) carriers showed surprisingly higher total cholesterol and LDL-cholesterol levels when they were stratified to the group with higher than median fiber intake. The results of this study highlight that high-fiber diets may positively affect anthropometric parameters but may also worsen lipid profile dependent on the FTO genotype.
γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer’s Disease-like Pathology and Neurodegeneration in a Mouse Model
Authors: Christopher Kwon Ye In , Xie Wei , Zhu Haizhou , Xie Jiashu , Shinn Keaton , Juckel Nicholas , Vince Robert , More Swati S. , Lee Michael K.
Published: November 2021

Oxidative stress in Alzheimer’s disease (AD) is mediated, in part, by the loss of glutathione (GSH). Previous studies show that γ-glutamyl transpeptidase (GGT)-resistant GSH analog, Ψ-GSH, improves brain GSH levels, reduces oxidative stress markers in brains of APP/PS1 transgenic mice, a mouse model of AD, and attenuates early memory deficits in the APP/PS1 model. Herein, we examined whether Ψ-GSH can attenuate the disease progression when administered following the onset of AD-like pathology in vivo. Cohorts of APP/PS1 mice were administered Ψ-GSH for 2 months starting at 8 month or 12 months of age. We show that Ψ-GSH treatment reduces indices of oxidative stress in older mice by restoration of enzyme glyoxalase-1 (Glo-1) activity and reduces levels of insoluble Aβ. Quantitative neuropathological analyses show that Ψ-GSH treatment significantly reduces Aβ deposition and brain inflammation in APP/PS1 mice compared to vehicle-treated mice. More importantly, Ψ-GSH treatment attenuated the progressive loss of cortical TH+ afferents and the loss of TH+ neurons in the locus coeruleus (LC). Collectively, the results show that Ψ-GSH exhibits significant antioxidant activity in aged APP/PS1 mice and chronic Ψ-GSH treatment administered after the onset of AD pathology can reverse/slow further progression of AD-like pathology and neurodegeneration in vivo.
Replacement of Cobalt in Lithium-Rich Layered Oxides by n-Doping: A DFT Study
Authors: Tuccillo Mariarosaria , Mei Lorenzo , Palumbo Oriele , Muñoz-García Ana Belén , Pavone Michele , Paolone Annalisa , Brutti Sergio
Published: November 2021

The replacement of cobalt in the lattice of lithium-rich layered oxides (LRLO) is mandatory to improve their environmental benignity and reduce costs. In this study, we analyze the impact of the cobalt removal from the trigonal LRLO lattice on the structural, thermodynamic, and electronic properties of this material through density functional theory calculations. To mimic disorder in the transition metal layers, we exploited the special quasi-random structure approach on selected supercells. The cobalt removal was modeled by the simultaneous substitution with Mn/Ni, thus leading to a p-doping in the lattice. Our results show that cobalt removal induces (a) larger cell volumes, originating from expanded distances among stacked planes; (b) a parallel increase of the layer buckling; (c) an increase of the electronic disorder and of the concentration of Jahn–Teller defects; and (d) an increase of the thermodynamic stability of the phase. Overall p-doping appears as a balanced strategy to remove cobalt from LRLO without massively deteriorating the structural integrity and the electronic properties of LRLO.
Imaging Techniques for Cardiac Function
Authors: Panis Vasileios , Donal Erwan
Published: November 2021

Cardiac imaging techniques include a variety of distinct applications with which we can visualize cardiac function non-invasively. Through different applications of physical entities such as sound waves, X-rays, magnetic fields, and nuclear energy, along with highly sophisticated computer hardware and software, it is now possible to reconstruct the dynamic aspect of cardiac function in many forms, from static images to high-definition videos and real-time three-dimensional projections. In this review, we will describe the fundamental principles of the most widely used techniques and, more specifically, which imaging modality and on what occasion we should use them in order to analyze different aspects of cardiac function.
Mechanical Performance of Confined Autoclaved Fly-Ash-Brick Masonry Walls under Cyclic Loading
Authors: Wen Bo , Zhang Lu , Niu Ditao , Gao Guanyi , Kang Yongkang , Luo Daming
Published: November 2021

In order to solve the limitations of masonry structures, such as poor seismic performance, complicated construction techniques, and energy wastage of wall materials, a new type of confined autoclaved fly-ash-brick wall was proposed and its mechanical performance was analyzed. An axial compression test of autoclaved fly-ash-brick short columns was carried out to analyze the failure mode and obtain the constitutive parameters of the brick. Meanwhile, a low-cyclic loading test of an assembly using an autoclaved fly-ash-brick wall was carried out to prove the correctness of the numerical model. Under multiple influencing parameters, the seismic performance of the assembly of autoclaved fly-ash-brick walls was analyzed by a numerical-simulation method. The results show that (1) the seismic performance of the assembled autoclaved fly-ash-brick walls is better than that of cast-in-place masonry walls; (2) low-strength mortar leads to premature cracking, which is unfavorable to earthquake resistance of the walls; and (3) the bearing capacity of the wall is increased and then decreased with the increase of the vertical compressive stress, so the number of layers of brick masonry structural should be limited. In addition, some construction measures were proposed to improve the mechanical performance of assembled autoclaved fly-ash-brick walls.
Investigation on Hydroplaning Behaviors of a Patterned Tire on a Steel Bridge Deck Pavement
Authors: Liu Yang , Qian Zhendong , Liu Changbo , Huang Qibo
Published: November 2021

The hydroplaning propensity on the steel bridge deck pavement (SBDP) is higher than ordinary road pavements. In this study, the objective is to develop a hydroplaning model to evaluate the hydroplaning behaviors for SBDPs. To achieve this goal, a finite element (FE) model of a 3D-patterned radial tire model was developed at first, and the grounding characteristics of tire on the SBDP were calculated as an initial condition for the follow-up hydroplaning analysis. The X-ray CT scanning device and Ostu thresholding method were used for image processing of pavement surface topography, and the 3D FE model of SBDP was established by the reverse stereological theory and voxel modeling technique, which can accurately reconstruct the pavement morphology. A fluid model was established to simulate the dynamic characteristics of water film between the tire and SBDP. On this basis, the tire–fluid–pavement interaction model was developed based on the CEL (Couple Eulerian–Lagrangian) algorithm, and it was verified by the hydroplaning empirical equations. Finally, the hydroplaning behaviors on the SBDP were studied. The findings from this study can provide a tool for hydroplaning evaluation on SBDPs, and will be helpful to improve the driving safety of SBDP in rainy days.
Systematic Review and Meta-Analysis of the Use of Hyaluronic Acid Injections to Restore Interproximal Papillae
Authors: Sanchez-Perez Arturo , Vela-García Tania Rosa , Mateos-Moreno Bibiana , Jornet-García Alfonso , Navarro-Cuellar Carlos
Published: November 2021

The absence of interdental papillae leads to the appearance of black triangles. For most patients, the appearance of these triangles is an important reason for concern and affects their social relationships. Multiple reconstruction techniques have been developed with different degrees of success and predictability. The main aim of this study was to evaluate the efficiency of hyaluronic acid (HA) injected into interproximal papillae 6 months after injection and to perform a systematic review and meta-analysis. After a systematic review, seven articles were selected: two clinical randomised controlled trials and five clinical trials. In total, 127 patients with a deficiency in upper papillae in the front of the maxilla and jaw were included in the study. The height variable was evaluated (mm) 6 months after HA injection. In total, 166 interproximal papillae were studied. Four articles showed an important difference in favour of intervention. The total result regarding in the injection of HA was favourable with an approximate average filling of 0.47 mm in the height of the interdental papilla. The injection of HA for the reconstruction of deficient papillae in the region of the upper and lower maxilla was a possible option treatment strategy in mild black triangles.
Mining Road Traffic Rules with Signal Temporal Logic and Grammar-Based Genetic Programming
Authors: Pigozzi Federico , Medvet Eric , Nenzi Laura
Published: November 2021

Traffic systems, where human and autonomous drivers interact, are a very relevant instance of complex systems and produce behaviors that can be regarded as trajectories over time. Their monitoring can be achieved by means of carefully stated properties describing the expected behavior. Such properties can be expressed using Signal Temporal Logic (STL), a specification language for expressing temporal properties in a formal and human-readable way. However, manually authoring these properties is a hard task, since it requires mastering the language and knowing the system to be monitored. Moreover, in practical cases, the expected behavior is not known, but it has instead to be inferred from a set of trajectories obtained by observing the system. Often, those trajectories come devoid of human-assigned labels that can be used as an indication of compliance with expected behavior. As an alternative to manual authoring, automatic mining of STL specifications from unlabeled trajectories would enable the monitoring of autonomous agents without sacrificing human-readability. In this work, we propose a grammar-based evolutionary computation approach for mining the structure and the parameters of an STL specification from a set of unlabeled trajectories. We experimentally assess our approach on a real-world road traffic dataset consisting of thousands of vehicle trajectories. We show that our approach is effective at mining STL specifications that model the system at hand and are interpretable for humans. To the best of our knowledge, this is the first such study on a set of unlabeled real-world road traffic data. Being able to mine interpretable specifications from this kind of data may improve traffic safety, because mined specifications may be helpful for monitoring traffic and planning safety promotion strategies.
Filament X-ray Tube Current Control Method Using Indirect Filament Temperature Estimation
Authors: Jang Je-Jin , Zhu He-Lin , Mok Hyung-Soo
Published: November 2021

The recent increase in ailments has increased the demand for diagnosis and surgery based on X-rays. An X-ray system using a filament-type tube heats the filament for operation, and the electrons emitted by the thermal energy during this process produce X-rays. Conventionally, current control-based methods are used to regulate heating. However, these methods do not control the temperature of the filament, resulting in lower or higher output than the desired dose rate. Therefore, we propose a filament temperature control method that enables constant temperature control, which cannot be achieved using the existing heating method for X-ray systems with filament tubes. Additionally, we developed an indirect temperature estimation algorithm for the tungsten filament to incorporate the proposed method. To validate the tube current control through temperature control, we performed experiments to compare the existing current-controlled heating and temperature control methods in terms of the filament temperature. As the tube current is proportional to the dose rate, it was measured through a comparative analysis of the change in the output of dose rate over time. The obtained results validate that the proposed method can maintain both the filament temperature and tube current at the desired level.
Using the Instrumented Indentation Technique to Determine Damage in Sintered Metal Matrix Composites after High-Temperature Deformation
Authors: Smirnov Alexander , Smirnova Evgeniya , Konovalov Anatoly , Kanakin Vladislav
Published: November 2021

The paper shows the applicability of data on the evolution of the elastic modulus measured by the instrumented microindentation technique to the determination of accumulated damage in metal matrix composites (MMCs) under high temperature deformation. A composite with a V95 aluminum alloy matrix (the Russian equivalent of the 7075 alloy) and SiC reinforcing particles is used as the research material. The metal matrix composite was produced by powder technology. The obtained results show that, under macroscopic compression at temperatures ranging between 300 and 500 °C, the V95\10% SiC MMC has the best plasticity at 300 °C. At a deformation temperature of 500 °C, the plastic properties are significantly lower than those at 300 and 400 °C.
Urban Effect on Sea-Breeze-Initiated Rainfall: A Case Study for Seoul Metropolitan Area
Authors: Choi Yuna , Lee Young-Hee
Published: November 2021

We examined the sea-breeze-initiated rainfall in the Seoul Metropolitan area (SMA) on 6 July 2017 using the weather research and forecasting (WRF) model. The model captures the arrival of the sea breeze front (SBF), the development of afternoon rainfall in the SMA, and the location of the sea-breeze-initiated maximum rainfall in the northeastern SMA reasonably well but overestimates the subsequent rainfall. We conducted sensitivity tests to better understand the urban effect on the sea-breeze-initiated rainfall event. Through factor separation analysis, we first examined the explicit role of sea and urban effect on sea-breeze-initiated rainfall. The results show that the interaction of sea and urban effects cause rainfall in the northwest and northeast of the SMA, indicating that both urban heat island circulation (UHIC) and sea breeze play an important role in the study case’s rainfall. We further examined the relative role of urban roughness and anthropogenic heat on the sea-breeze-initiated rainfall through factor separation analysis. Both anthropogenic heat and urban roughness play a role in increasing precipitation in the northeastern area of the SMA, with a larger contribution of anthropogenic heat than urban roughness. The relationship between low-level convergence at the SBF and urban factors is discussed.