bluuebunny/crossref_metadata_2025 huggingface dataset:
Azospirillum Actinidiae sp. nov., a Nitrogen-Fixing Bacterium Isolated From The Roots of Kiwifruit Plants
Authors: Yang Ying , Zhu Yue , Li Wei , Ren Yajing , Huang Shengxiong , Liu Yongsheng
Published: December 2021

A novel diazotrophic bacterium, designated CCTCC AB 2021101T, was isolated from fresh roots of kiwifruit. Cells of strain CCTCC AB 2021101T were Gram-negative, aerobic and rod-shaped, with motility provided by peritrichous flagella. The 16S rRNA analysis showed that strain CCTCC AB 2021101T belongs to the genus Azospirillum and is closely related to Azospirillum melinis (98.32%), Azospirillum oryzae (97.73%), Azospirillum lipoferum (96.98%), Azospirillum humicireducens (96.49%) and Azospirillum largimobile (96.01%) and lower sequence similarity (<96.0 %) to all other species of the genus Azospirillum. Strain CCTCC AB 2021101T was able to grow well at 35–40℃ and pH 6.0–7.0, and tolerated up to 3.0 % (w/v) NaCl. The major saturated fatty acids are C14:0, C16:0 and C18:0. C18:1 ω7c and C16:0 3-OH were the major unsaturated and hydroxylated fatty acid. The G+C content was 67.8 mol%. Strain CCTCC AB 2021101T gave positive amplification for dinitrogen reductase (nifH gene). Highest nifH gene sequence similarities were obtained with Azospirillum brasilense AWB14T(95.9%), Azospirillum zeae Gr24T(95.56%), Azospirillum picis DSM 19922T(96.79%), Azospirillum lipoferum B22T(94.88%) and Azospirillum oryzae COC8T(94.88%). The activity of the nitrogenase of the strain was further confirmed by acetylene-reduction assay, which was recorded as 81 nmol ethylene h-1. Based on these data, strain CCTCC AB 2021101T is considered to represent a novel endophytic diazotrophs species in the genus Azospirillum, for which the name Azospirillum actinidiae sp. nov. is proposed. The type strain is CCTCC AB 2021101T.
Dynamic Zero-Covid strategy curtails mutagenesis and emergence of new variants of the SARS-CoV-2
Authors: Cui Lunbiao , Zhu Liguo , Zhang Jun , Fan Huafeng , Yi Yongxiang , Zhao Jun , Ge Yiyue , Wang Shenjiao , Han Xu , Gao Xingsu , Qi Xian , Fu Jianguang , Li Zhifeng , Fan Huan , Yu Huiyan , Deng Fei , Zhao Kangchen , Zhu Xiaojuan , Hu Jianli , Li Jianjun , Ai Jing , Kang Guodong , Shen Ya , Jin Guangjie , Wang Furu , Zhang Zhong , He Min , Ding Songning , Wang Yin , Dong Yuying , Huang Yao , Yi Changhua , Wang Longyu , Jiao Yudong , Wang Jinfu , Li Jian , Liu Hongde , Li Jingxin , Bao Changjun , Wu Ming , Zhu Fengcai
Published: December 2021

Within the local outbreak period of SARS-CoV-2 Delta variant in Nanjing and Yangzhou, China, we analyzed the mutation process of the Delta variants in 520 cases, as well as the production, spread and elimination of new mutant strains under the non-pharmaceutical interventions (NPI) strategy. The investigation on distribution of COVID-19 cases and phylogenetic analysis of SARS-CoV-2 genome sequences attributed to tracking the transmission chains, transmission chains were terminated by the isolation of the COVID-19 patients and quarantine of close-contracts, suggesting the importance of NPI in prompting some mutations to disappear and stopping the transmission of new variants. Dynamic zero-Covid strategy has been implemented successfully to against the second-largest local epidemic caused by an imported COVID-19 case in China.
Circular RNA CircCSPP1 Promotes the Occurrence and Development of Colon Cancer by Sponging miR-431 and Regulating the Expressions of ROCK1 and ZEB1
Authors: Wang Jin , Zhou Lei , Chen Bingxin , Yu Zhuwen , Zhang Jianglei , Zhang Zhe , Hu Chenrui , Bai Yanjin , Ruan Xiaokang , Wang Shengjia , Ouyang Jun , Wu Airong , Zhao Xin
Published: December 2021

Colon cancer is a common malignant tumor of the digestive tract, and its incidence is ranked third among gastrointestinal tumors. The present study investigated the role of a novel circular RNA (circCSPP1) in colon cancer and explored the possible underlying molecular mechanisms. Bioinformatics analysis and reverse transcription-quantitative PCR were used to detect the expression levels of circCSPP1 in colon cancer specimens and cell lines. The effects of circCSPP1 on the behavior of colon cancer cells were investigated using CCK-8, Transwell and clonogenic assays. Bioinformatics analysis along with luciferase, fluorescence in situ hybridization and RNA pull-down assays were used to reveal the interaction between circCSPP1, microRNA (miR)-431, Rho associated coiled-coil containing protein kinase 1 (ROCK1) and zinc finger E-box binding homeobox 1 (ZEB1). It was found that circCSPP1 expression was significantly upregulated in colon cancer tissues and cell lines. The overexpression of circCSPP1 significantly promoted the proliferation, migration and invasion of colon cancer cells, whereas the silencing of circCSPP1 exerted opposite effects. Mechanistically, circCSPP1 was found to bind with miR-431. In addition, ROCK1 and ZEB1 were identified as the target genes of miR-431. Rescue experiments further confirmed the interaction between circCSPP1, miR-431, ROCK1 and ZEB1. Moreover, circCSPP1 promoted the expression levels of ROCK1, cyclin D1, cyclin-dependent kinase 4, ZEB1 and Snail, and lowered the E-cadherin expression level. Notably, circCSPP1 from SW620 cells was transferred to macrophages via exosomes and enhanced the colon cancer microenvironment. Taken together, the findings of the present study indicated that circCSPP1 may functions as a competing endogenous RNA in the progression of colon cancer by regulating the miR-431/ROCK1 and miR-431/ZEB1 signaling axes.
What is Polypharmacy In People Living With HIV/AIDS? A Systematic Review
Authors: Danjuma Mohammed Ibn-Mas’ud , Khan Safah , Wahbeh Farah , Naseralallah Lina Mohammad , Elzouki Abdelnaser
Published: December 2021

Polypharmacy in people living with HIV/AIDS (PLWHA) is a rising morbidity that exacts hefty economic burden on health budgets in addition to other adverse clinical outcomes. Despite recent attempts, uncertainty remains around its exact definition in PLWHA. In this synthesis, we explored relevant databases (PUBMED, EMBASE, CROI) for studies evaluating polypharmacy in PLWHA from January 2000 to August 2021. Two independent reviewers extracted and reviewed relevant variables for analyses. The review included a total of 31 studies involving n = 53347 with a mean age of 49.5 (SD±17.0) years. There was a total of 36 definitions, with 93.5% defining polypharmacy as the concomitant use of 5 or more medications. We found significant variation in the numerical definition of polypharmacy, with studies reporting it as “minor” (N = 3); “major” (N = 29); “severe” (N = 2); “excessive” (N = 1); and “higher” (N = 1). Most studies did not incorporate a duration (84%) in their definition and excluded ART medications (67.7%). A plurality of studies in PLWHA have established that polypharmacy in this cohort of patients is the intake of ≥5 non-ART medications. To standardize the approach to addressing this rising morbidity, we recommend incorporation of this definition into national and international PLWHA treatment guidelines.
Decreased Expression of KPNA2 in Hepatocellular Carcinoma Infers Favorable Prognosis and High Immune Infiltrating Level
Authors: zhu kangming , zhang yvndi , yvan hui , li jing
Published: December 2021

BackgroundLiver hepatocellular carcinoma (LIHC) is an important pathological type of liver cancer. The immune infiltration of the tumor microenvironment is negatively correlated with the overall survival rate of LIHC. At present , the role and molecular mechanism of KPNA2 in LIHC have not been elucidated, and the prognostic correlation between the two and the immune infiltration of LIHC are still unclear. Our study evaluated the role of KPNA2 in LIHC through TCGA data.MethodGene expression profiling interactive analysis (GEPIA) is used to analyze the expression of KPNA2 in LIHC. We evaluated the impact of KPNA2 on the survival of LIHC patients through the survival module. Then, We downloaded the LIHC data set from TCGA. Logistic regression was used to analyze the correlation between clinical information and KPNA2 expression. Cox regression analysis was used to analyze the clinicopathological characteristics related to the overall survival rate of TCGA patients. In addition, we used the "correlation" modules of CIBERSORT and GEPIA to explore the correlation between KPNA2 and cancer immune infiltrate. Western blotting was used to detect the expression of KPNA2.ResultUsing logistic regression for univariate analysis, increased KPNA2 expression was significantly correlated with pathological stage, tumor status, and lymph node status. In addition, multivariate analysis showed that down-regulation of KPNA2 expression, negative pathological stage and distant metastasis are independent prognostic factors for good prognosis. Specifically, CIBERSORT analysis was used to establish a negative correlation between the up-regulated expression of KPNA2 and the level of immune infiltration of B cells, NK cells, mast cells, and T cells. In addition, we confirmed this in the "Association" module of GEPIA. The expression of KPNA2 in LIHC tissues was significantly lower than that in adjacent normal tissues by western blotting.ConclusionThe down-regulation of KPNA2 expression is associated with a good prognosis and an increase in the proportion of immune cells in LIHC. These conclusions indicate that KPNA2 is related to the level of immune infiltration of LIHC and can be used as a potential prognostic biomarker of LIHC and a potential target for clinical tumor treatment.
COLLABORATION CLASS TEACHERS AND CONSELORS IN DIRECTING STUDENTS 'CLASS XII HIGH SCHOOL INTERESTS DETERMINING THE CONTINUATION AT SMA NEGERI 1 PATIANROWO
Authors: SEPTIANA NILA ZAIMATUS , UMATIN CHOIRU
Published: December 2021

This research is presented to anticipate the future steps of class XII students in making a decision regarding their interests through the collaboration of teachers and counselors. Data collection in this study uses observation and interview techniques. The data of this study were obtained from BK teachers or counselors at SMAN 1 Patianrowo Nganjuk, East Java. Data analysis in this study uses narrative analysis. The subject is students in class VII of SMAN 1 Patianrowo. These findings reveal that many of the students have not been aware of their interests. Learners are directed more in academic matters only and have not led to the development of the potential of students such as direction of the students' interests. Few of the students can develop the interest they have because the teacher is more focused on academics and the counselor is more focused in dealing with problems experienced by students. The collaboration process of the classroom teacher and counselor is carried out in the form of recorded and unrecorded. Recorded collaborations such as the conduct of scheduled aptitude interest tests in class X and class XII early. While not recorded like communication between class teachers and counselors related to the interests of students through analysis in the daily lives of students. This is an effort to find out the interests of students from an early age which is then reaffirmed by the procurement of scholastic tests at the beginning of entering class XII. In conducting group counseling, counselors use the opportunity in spare time or when there is a class that is not in the learning process to do group guidance in the classroom. While for personal guidance, the counselor calls one student at a time. However, not all must be called, but many of the students voluntarily come to see the counselor by themselves for guidance.
Resilience ability and small medium enterprise (SME) survival rate in the middle of business environmental fluctuation
Authors: Affa Ahmad Syaiful , Wibowo Muh. Ghafur , Berakon Izra
Published: December 2021

Purpose – This study examines the effect of organizational resilience variables on the firm’s survival rate and the moderating role of environmental turbulence variables in the relations of organizational resilience and firm survival.Method – This study uses simple regression to test research hypotheses. Primary data in the form of questionnaires are obtained from Small and Medium Enterprises (SMEs) in Java.Result – The analysis shows that organizational resilience variables can improve the firm’s survival. However, this study did not find the moderating role of environmental turbulence in influencing the relationship between organizational resilience variables and firm survival.Implication – This study can help scholars and practitioners to understand more of the mechanism of organizational resilience and its impact on survival on smaller firms.Originality – This study offer the empirical study of firm survival on small-medium enterprise setting in Indonesia.
Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Cardiac Structural
and Electrical Remodeling: From Myocardial Cytology to Cardiodiabetology
Authors: Marketou Maria , Kontaraki Joanna , Maragkoudakis Spyros , Danelatos Christos , Papadaki Sofia , Zervakis Stelios , Plevritaki Anthoula , Vardas, Panos , Parthenakis Fragiskos , Kochiadakis George
Published: December 2021

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have changed the clinical landscape
of diabetes mellitus (DM) therapy through their favourable effects on cardiovascular outcomes.
Notably, the use of SGLT2i has been linked to cardiovascular benefits regardless of DM status,
while their pleiotropic actions remain to be fully elucidated. What we do know is that SGLT2i
exert beneficial effects even at the level of the myocardial cell and that these are linked to an improvement
in the energy substrate, resulting in less inflammation and fibrosis. SGLT2i ameliorates
myocardial extracellular matrix remodeling, cardiomyocyte stiffness and concentric hypertrophy,
achieving beneficial remodeling of the left ventricle with significant implications for the pathogenesis
and outcome of heart failure. Most studies show a significant improvement in markers of diastolic
dysfunction along with a reduction in left ventricular hypertrophy. In addition to these effects,
there is electrophysiological remodeling, which explains initial data suggesting that SGLT2i have
an antiarrhythmic action against both atrial and ventricular arrhythmias. However, future studies
need to clarify not only the exact mechanisms of this beneficial functional, structural, and electrophysiological
cardiac remodeling but also its magnitude to determine whether this is a class or a
drug effect.
A Real-world Evidence-based Management of HIV by Differential Duration
HAART Treatment and its Association with Incidence of Oral Lesions
Authors: Li Cheng-Wen , Shu Wen , Du Fei , Bai Jin-Song , Yin Ling-Yun , Duan Kai-Wen
Published: December 2021

Background:

The efficacy of highly active antiretroviral therapy (HAART) therapy can be estimated by immunological response and the incidence of opportunistic infections.

Objective:

To evaluate the effectiveness of different durations of HAART in terms of immunological response markers (CD4 count and CD4/CD8 ratio) along with disease progression markers (incidence of oral lesions) in Chinese patients with HIV.

Methods:

This single-center, retrospective, real-world study included patients with HIV, grouped into treatment group and treatment-naïve group of which the former was further divided into (6, 12, and 18 months) based on the treatment duration. The CD4 and CD8 cell counts were analyzed by the FACSCalibur flow cytometry. Kruskal-Wallis test was applied to determine the outcome of different duration of HAART. Oral examination was carried out according to the WHO type IV examination

Results:

In 246 patients with HIV, CD4 counts increased significantly post-HAART compared with pre-HAART in all three treatment groups (P<.001), while CD8 count decreased significantly (P<.05) in all three treated group. A significant association of HAART with CD4/CD8 ratio was observed (P<.001). A significant increase in CD4 count was observed between 12-month and 18-month treatment group (P<.05). The occurrence of oral lesions reduced significantly in the treatment group.

Conclusion:

We observed a better response of HAART regimen with 18 months of duration than 12-months and 6-months therapies and reduction in oral lesions.
Molecular Docking of the Terpenes in Gorgonian Corals to COX-2 and
iNOS Enzymes as Anti-Inflammatory
Authors: Kelutur Faruk Jayanto , Saptarini Nyi Mekar , Mustarichie Resmi , Kurnia Dikdik
Published: December 2021

Background:

Because the inflammatory pathway is triggered by the enzymes cyclooxygenase-
2 (COX-2) and inducible nitric oxide synthase (iNOS), inhibitors, such as nonsteroidal anti-inflammatory
drugs (NSAIDs), are needed, although these have side effects. Therefore, the discovery and development
of natural medicine as a lead compound are needed. The gorgonian corals have been reported to contain
cyclic diterpenes with anti-inflammatory activities. The specific anti-inflammatory inhibitor potential has
not been reported regarding these secondary metabolites, whether in COX-2 or iNOS. Thus, the in silico
method is the right alternative.

Objective:

This study aimed to determine the potency of fifteen terpenes of the various gorgonian corals
to COX-2 and iNOS enzymes as an anti-inflammatory.

Methods:

Molecular docking was performed using ChemDraw Ultra 12.0, Chem3D Pro 12.0, Biovia
Discovery Studio 2016 Client®, Autodock Tools 4.2, prediction pharmacokinetics (Pre-ADMET), and
oral administration (Lipinski rule of five).

Results:

Potential terpenes based on ΔG (kcal/mol) and Ki (nM) to COX-2 were gyrosanol B (-10,32;
27,15), gyrosanol A (-10,20; 33,57), echinolabdane A (-9,81; 64,76). Only nine terpenes were specific to
COX-2 active sites, while for iNOS were palmonine F (-7.76; 2070), briarenol C (-7.55; 2910), and all
test compounds binding to the iNOS active sites. Pre-ADMET prediction obtained that HIA was very
excellent (70–100%), Caco-2 had moderate permeability (4–70 nm sec-1), and PPB had strong binding (>
90%). Eight terpenes qualified for the Lipinski rule of five.

Conclusion:

iNOS was a specific target for terpenes based on the free energy of binding (ΔG).
Fetal Cardiac Function: Myocardial Performance Index
Authors: Oliveira Mariana , Dias Joana Portela , Guedes-Martins Luís
Published: December 2021

The Myocardial Performance Index (MPI) or Tei index, presented by Tei in 1995, is the
ratio of the sum of the duration of the isovolumetric contraction time (ICT) and isovolumetric relaxation
time (IRT) to the duration of the ejection time (ET). The Modified Myocardial Performance
Index (Mod-MPI), proposed in 2005, is considered a reliable and useful tool in the study of fetal
heart function in several conditions, such as growth restriction, twin-twin transfusion syndrome,
maternal diabetes, preeclampsia, intrahepatic cholestasis of pregnancy, and adverse perinatal outcomes.
Nevertheless, clinical translation is currently limited by poorly standardised methodology
as variations in the technique, machine settings, caliper placement, and specific training required
can result in significantly different MPI values. This review aims to provide a survey of the relevant
literature on MPI, present a strict methodology and technical considerations, and propose future
research.
On the issue of the relationship between civil and tax law in terms of the application of certain methods of ensuring the fulfillment of obligations
Authors:   V. А. Ochakovsky Kuban State Agrarian University named after I.T. Trubilin, Ochakovsky V. А. , Archireeva A. S. ,   A. S. Archireeva Kuban State Agrarian University named after I.T. Trubilin, Seropol D. I. ,   D. I. Seropol Kuban State Agrarian University named after I.T. Trubilin
Published: December 2021

This paper examines the relationship between the norms of civil and tax legislation in terms of the application of certain methods of ensuring the fulfillment of obligations. These branches of law have different reasons for these obligations. Civil legislation, in comparison with tax legislation, provides for dispositiveness in the legal regulation of those methods of ensuring the fulfillment of obligations, where tax legislation provides for a mandatory norm. But nevertheless, despite this, the analysis revealed the general provisions of the two industries.
On the issue of violation of the uniformity of judicial practice
Authors:   N. Sh. Gadzhialieva Dagestan State University, Gadzhialieva N. Sh.
Published: December 2021

The article is devoted to such grounds for the cancellation or amendment of court decisions in the supervisory procedure, as a violation of the uniformity of judicial practice. The author analyzes the provisions of the current civil procedure legislation, the explanations of the Plenum and the Presidium of the Supreme Court of the Russian Federation on the application of paragraph 3 of Article 391.9 of the Civil Procedure Code of the Russian Federation. The article identifies such problems as the lack of normative consolidation of the terms "judicial practice" "unity of judicial practice", the uncertainty of the legal status of acts of the highest judicial instance, the possibility of bringing judges to disciplinary responsibility for violating the unity of judicial practice. Based on the results of the study, the author comes to the conclusion that comprehensive legislative changes are necessary to achieve the unity of judicial practice
To the development of state formations of ethnic daghestanians of Transcaucasia in the periods of Middle Ages and New Time
Authors:   T. M. Aitberov Dagestan State University, Aitberov T. M. , Abdullaev M. N. ,   M. N.  Abdullaev Dagestan State University
Published: December 2021

The article deals with the development of state formations of ethnic Dagestanis as part of the indigenous population of Transcaucasia. Among scientists, it is generally believed that they are divided: a) for Lezgins and small ethnic groups closely related to them (within Azerbaijan, these are Khinalug, Shahdag-Kryz and Budukhs, Udins, Tsakhurs and Rutuls); b) for Avars. In this article, for the first time, the third relatively large ethnic community of the region is reasonably recorded — the Transcaucasian Dargins (Kaitagans). It is noted that the Dagestani-speaking population of Transcaucasia owned fertile lands, formed a kind of military class and was widely represented in the military-political elite of society. It was state-organized, had its own sources of law. Scientists usually derive the roots of the state and legal development of ethnic dagestanis of Transcaucasia from Caucasian Albania. In this article, the idea is carried out that this provision can be attributed only to a part of the native speakers of the Dagestan languages of the region. As for the Dagestani-speaking population of the left bank of the Alazani, known to Kavkaz scholars as the Zakatala district, along with some adjacent lands, the authors derive the deepest roots of its development in these areas — the state and law — from Lpinia, a strong state of the Transcaucasia of the Sassanid era. The authors conclude that by the end of the Mongolian era, the ethnic Dagestanis of Transcaucasia — despite centuries of being under the rule of Georgian feudal lords and assimilation processes taking place in the region — managed to preserve their ethno-territorial identity, unity and continuity in the development of the institutions of statehood and law. This was facilitated by geographical and religious factors, as well as the continuing organic ties with historical Dagestan. Special attention is paid to the political centers of the revival and development of the statehood of ethnic Dagestanis on the western slopes of the Main Caucasian Ridge during the Middle Ages and modern times
Medical activities and innocent cause of harm: criminal legal aspects
Authors:   V. N. Voronin Kutafin Moscow State Law University (MSLA), Voronin V. N.
Published: December 2021

The subject of the research is public relations in the field of application of art. 28 of the Criminal Code RF ("Innocent infliction of harm") in relation to medical workers. The author reveals certain problems of establishing a case (case) in case of defects in the provision of medical care, as well as the actions of a doctor in connection with neuropsychic overloads. The author proposes grounds for expanding the scope of application of art. 28 of the Criminal Code and minimization of the criminal law risk of a medical worker. The article presents and systematizes the main theoretical views on innocent harm in medicine, and also examines the available practical cases. The research methodology is based on private methods of legal analysis and legislative technique
On some problems and prospects of countering extremism and terrorism in the criminal executive system
Authors:   S. N. Smirnov  Academy of the Federal Penitentiary Service, Smirnov S. N. , Moiseev N. D. ,   N. D. Moiseev Academy of the Federal Penitentiary Service
Published: December 2021

The article deals with some issues related to the detention of persons sentenced to imprisonment for crimes of a terrorist nature and extremist orientation. The authors, based on the analysis of departmental instructions, instructions, reports on countering extremism and terrorism in the criminal executive system of Russia, the practical activities of institutions and bodies executing criminal penalties, outlined the most important problems in this direction. In addition, the paper considers the main measures of preventive work of terrorist and extremist manifestations, based on the provisions of the Comprehensive Plan for Countering the Ideology of Terrorism in the Russian Federation for 2019-2023.
Specifics of taking into account the elderly age of the victim of the crime when sentencing
Authors:   A. V. Sokolova Vladimir Law Institute of the Federal Penitentiary Service of Russia, Sokolova A. V.
Published: December 2021

The article is devoted to considering the specifics of taking into account the elderly age of the victim of the crime when sentencing. The author has analysed a number of crimes in which older persons were victims of violence, deception or other criminal manifestations. As a result of the study, a change was proposed to article 63 of the Criminal Code of the Russian Federation, aimed at increasing the effectiveness of criminal legislation in achieving the goals of protecting older people.
Legal problems of compliance with information regimes by medical workers in social networks
Authors:   A. V. Basova Saratov State Medical University named after V. I. Razumovsky, Basova A. V. , Vlasova M. V. ,   M. V. Vlasova Saratov State Medical University named after V. I. Razumovsky
Published: December 2021

In the context of the digitalization of society, social networks often become an integral part of the professional activity of a doctor. Publications of photo and video materials reflecting the various stages of providing medical care to patients on the personal pages of social networks of practicing doctors are available for viewing by an indefinite circle of people. The virtual space acts as a platform that determines the competence, professionalism of the doctor, the quality of the medical care provided by him. At the same time, when promoting medical services to the population through social networks, the personal pages of doctors in «Instagram» and «VKontakte» show illustrative examples of medical practice: photos of patients' faces and body parts before receiving medical services (operations, cosmetic procedures, treatment of skin diseases, diet therapy), followed by the presentation of exceptionally successful results. At the same time, photos are often shown without means of correcting biometric personal data of patients, which reduce the risk of their identification on the Internet (applying a black stripe on the face or body parts, "blurring" identification zones). Such publications may contain inappropriate information for the perception of children of certain age groups. Formal legal, logical, statistical, and systematic research methods were used. Based on the survey of doctors who conduct social networks for work purposes, the level of their legal literacy and legal problems of maintaining professional social accounts are determined. Based on the analysis of the sources of legal regulation of medical activity, the obligation to comply with the information regimes of medical workers in social networks, the authors attempt to form a legal regulation of the conduct of social networks by medical workers in Russia. A complex, multi-level system of legal regulation of public relations to ensure the availability of information by medical professionals in social networks is revealed. A number of organizational measures are proposed to improve the level of legal literacy of practitioners, and practical recommendations are given on the proper use of photo and video materials of patients in social networks to avoid disputes between participants in these relationships
The importance of legal awareness for quality education in the digitalization of Russian society
Authors:   A. M. Drozdova North-Caucasian Federal University, Drozdova A. M.
Published: December 2021

The article is devoted to the main problems related to the formation of the national worldview and the legal consciousness of the individual in the information society. The relationship between the education of the legal consciousness and the creation of conditions for raising the level of the legal culture of the population are also raised. The analysis is subject to understanding of the legal worldview in the relationship with the legal culture of the process of development of the information society and informatization of education in the university. The current state of education in Russia and the prospects for reforming the Russian education system in connection with the introduction of the Education 2030 Concept are considered
On the social and psychological conditions of the realization of the human right to the protection of the law
Authors:   A. T. Ragimov Dagestan State University, Ragimov A. T.
Published: December 2021

The article examines the mechanisms of the impact of social and psychological factors on the realization of the human right to the protection of the law. This problem is considered through the prism of human rights relations, which allow us to demonstrate in dynamics how these factors affect the state of human rights relations between a person and the state. An attempt is made to show the peculiarities of the influence of social and psychological phenomena on the behavior of a person who finds himself in the role of an authorized party to a legal relationship and on the behavior of a state that finds itself in the role of an obligated party to a legal relationship
Constitutional reform 2020 and problems of protection of rights and freedoms of human and citizen in Russian Federation
Authors:   N. А. Gazimagomedova Dagestan State University, Gazimagomedova N. А.
Published: December 2021

The article discusses the problems of further improving the theory and legislation of constitutional law, as well as the practice of ensuring and protecting human and civil rights and freedoms in the Russian Federation based on the novels of the constitutional reform of 2020. All-Russian requirements in the regions of the North Caucasian Federal District.
The Constitutional Court of the Russian Federation in the light of the Constitutional reform of 2020: some issues of theory and practice
Authors:   S. A. Saibulaeva Dagestan State University, Saibulaeva S. A.
Published: December 2021

Based on the study of historical and legal material, theoretical and practical generalizations, the article examines the issues of organizational and functional reform of the Constitutional Court of the Russian Federation in the light of the constitutional reforms of 2020 and the impact of this process on the establishment of the Russian constitutional system in its modern sense. Certain aspects of the functioning of the constitutional control bodies of foreign state-legal systems are analyzed. The purpose of the study is to determine the structural changes in the Russian legislation, their impact on the political and legal status of the federal body of constitutional control and trends in the development of the system of interaction of the highest state authorities. It is shown that constitutional changes have a systemic impact on both the Constitutional Court of the Russian Federation and the constitutional system of the Russian state as a whole. The author draws attention to the possibility of functioning of a democratic state only if there is an independent and independent federal body of constitutional control.
Essence and content of the financial activities of subjects of the Russian Federation
Authors:   N. M. Ataeva Dagestan State University, Ataeva N. M.
Published: December 2021

The aims of the article are to research problems of Russian Federation’s subjects financial activity and to analyze this term as one of the attribute of the Federation’s subject. Authors adhere the traditional approach of understanding financial activity of subjects of the Russian Federation, which has been researched in law science. There is researching of following terms: financial federalism, budgetary federalism, their basics, essence and content of the financial activities of subjects of the Russian Federation. Writing the article authors use different scientific methods, such as dialectical, logical, formal and legal, analysis and synthesis. In conclusion, author gave her own term of financial activities of subjects of the Russian Federation.
Risk-oriented approach during the implementation of the regulatory guillotine mechanism in the implementation of state control (supervision) of compliance with the mandatory requirements of the legislation of the Russian Federation in the field of safety of hydraulic structures: legal collision
Authors:   Z. М. Kadiev Caucasian Department of the Federal Service for Environmental, Technological and Nuclear Supervision (Rostechnadzor), Kadiev Z. М. , Kochetov А. N. ,   А. N. Kochetov North-Western Department of the Federal Service for Environmental, Technological and Nuclear Supervision (Rostechnadzor)
Published: December 2021

«Risk-based approach» is a relatively new concept introduced into the legislation of the Russian Federation relatively recently. There are a number of issues related to its implementation in practice, the solution and explanation of which should have a systematic approach. This will make it possible to bring the regulatory legal framework in the field of mandatory requirements for ensuring the safety of hydraulic structures to the unity and consistency of legislation, the formation of a uniform practice of applying the introduced legal norms.
Specifics of civil and labor relations between the general director and the business company. Part 2
Authors:   E. B. Abakumova Institute of philosophy and law SB RAS, Novosibirsk military Institute of the national guard of the Russian Federation named after General of the army I. K. Yakovlev, Abakumova E. B.
Published: December 2021

This article continues the scientific study of the specifics of labor and civil law relations between a business company and a person performing the functions of a sole executive body. The author considers the legal features of the suspension and early termination of the powers of the sole executive body of the company, shows the relationship between the norms of labor and civil legislation
Total Talar Replacement with Ceramic Implant in Combination with Tibial Component of Ankle Endoprosthesis: A Case Report
Authors: Kuznetsov Vasilii V. , Gudi Sergei M. , Skuratova Liliya K. , Pakhomov Igor A.
Published: December 2021

Background. Surgical treatment of patients with talus posttraumatic aseptic necrosis and its consequences usually includes tibiotalocalcaneal arthrodesis with various foot joints according to additional indications. This type of surgical treatment has number of significant disadvantages: traumatic surgical technique, permanent loss of movement in functionally significant joints, high risk of non-union, high frequency of residual deformities, the need for long periods of limb immobilization. The question arises: how to overcome the existing disadvantages and improve the results of talus posttraumatic aseptic necrosis treatment? A potential solution to this problem is the total talus endoprosthetics. Clinical case. A 64-year-old patient came to the clinic complaining of pain and deformity of the right foot and ankle area. After the examination, talus posttraumatic aseptic necrosis was diagnosed. The patient underwent ankle joint arthroplasty using total talus ceramic endoprosthesis in combination with the tibial component of the ankle joint endoprosthesis, a course of rehabilitation treatment was performed. Results. The VAS and AOFAS scales indicators showed a significant improvement both in the pain decrease (from 75 mm before surgery to 10 mm after), and in the functional state according to AOFAS by 2.2 times (from 36 to 80 points 20 months after surgery). By the last follow-up the patient could take more than 8000 steps a day. Conclusion. Considering the good clinical result achieved, the ankle joint arthroplasty using total talus ceramic endoprosthesis in combination with the tibial component of the ankle joint endoprosthesis can be considered a promising method of treatment of this severe pathology.
Patrones de distribución espacial del arbolado en un bosque de Pseudotsuga menziesii en Chihuahua, México
Authors: García-García Samuel Alberto , Alanís-Rodríguez Eduardo , Rubio-Camacho Ernesto Alonso , Aguirre-Calderón Oscar Alberto , Treviño-Garza Eduardo Javier , Graciano-Ávila Gabriel
Published: December 2021

El objetivo de este estudio fue caracterizar los patrones de distribución espacial de un bosque maduro en el estado de Chihuahua, México, donde coexisten coníferas de importancia para la conservación como Pseudotsuga, Picea y Abies. Se utilizó un análisis de patrón de puntos para evaluar mezcla de especies, diferenciación y dominancia dimensional. Los datos se obtuvieron de ocho sitios de muestreo de 1000 m2. Se analizaron de manera general 203 grupos estructurales, Pseudotsuga generó 84, Quercus 22 y Pinus 42, reflejando una distribución aleatoria de acuerdo con el índice de uniformidad de ángulos (Wi), mientras que el grado de mezcla (Mi) manifestó que la especie referencia cuenta con más de dos vecinos de diferente especie. No se registraron diámetros y alturas dominantes de manera general ya que (UDi) y (UHi) mostraron valores similares en cada uno de los grados de dominancia, la diferenciación dimensional (TDi), (THi) fue moderada, similar a estudios en bosques perturbados y bajo manejo. El conocimiento de la dinámica de bosques maduros es vital para una descripción precisa de las relaciones entre especies de manera más auténtica y puede ser base para la conservación o futuras restauraciones en áreas perturbadas.
Professor Leon Padlewski — director of the bacteriological institute
Authors: Chaban M.P. , Shevtsova Z.I. , Gaponov V.V.
Published: December 2021

The article presents the life path of an epidemiologist, professor Leon Padlewski, a native of Poland. He became the first director of the bacteriological institute in Yekaterinoslav. Information about his wife Nadieżda (nee Berestnieva), a well-known pianist, the founder of the Belarusian piano school, was provided. Atragic fate befell Padlewski sons, who died in the fight against the Nazis. The elder son Jerzy was an architect, and the younger son Roman was a composer.
Проектирование высоковольтного трехканального регулятора напряжения для применений в автомобильной промышленности
Authors: Силаев А.С. , Полевиков В.В. , Шомахмадов Д.П. , Степанов С.А. , Мариненко В.С. , Сорока С.В. , Литвиненко Э.О. , Юров А.С. , Калбазов Д.Н. , Никифорова С.А. , Андриенко Е.Н.й , Гуляева А.Р. , Мещеряков Ю.А.
Published: December 2021

Представлены принципы проектирования трехканального стабилизатора напряжения. Современные технологии интеллектуального управления питанием позволяют реализовать сложную функциональность в одной схеме. Одно из возможных применений систем управления питанием – стабилизатор напряжения. Важную роль играют такие параметры системы, как генерируемые уровни напряжения и/или тока, контроль температуры в реальном времени и различные виды ошибок, о которых ключ сообщает центральному контроллеру в режиме реального времени. Минимальное время переключения регулятора снижает вероятность возникновения ошибки, связанной с шумами цепей питания микросхемы. Интеллектуальные технологии управления питанием позволяют разрабатывать специа­лизированные системы, такие как антиблокировочная система тормозов, управление подушками безопасности и управление двигателем автомобиля. Близки по структуре и системы промышленной электроники, телекоммуникаций и обработки данных. Современные системы позволяют управлять питанием и внешними системами, исследовать системы на наличие ошибок или опасных условий. Предлагаемое решение позволяет обеспечить стабильное выходное напряжение в широком диапазоне входных напряжений. Описаны основные функции устройства: функция ограничения выходного тока, защита от обратной полярности, температурная защита, функция ограничения превышения выходного напряжения, цифровая функция встроенного таймера watch dog, предназначенного для подключения конструкции к микроконтроллеру.
РОССИЙСКАЯ ПРОМЫШЛЕННОСТЬ СМОЖЕТ ОБЕСПЕЧИТЬ ПРОДУКЦИЮ ДЛЯ ОБЪЕКТОВ КИИ К 2025 ГОДУ
Authors: Попов С.
Published: December 2021

30 ноября Издательский дом "Коммерсантъ" при поддержке Департамента радиоэлектронной промышленности Министерства промышленности и торговли России организовал в Москве в очном формате конференцию "Технологическая независимость: возможности и ограничения".
О РЕГУЛИРОВАНИИ РАЗВИТИЯ ЦИФРОВОЙ СРЕДЫ
Authors: Ластович Б.
Published: December 2021

Обсуждаются проблемы, ставящие под угрозу достижение целей Нацио­нальной программы "Цифровая экономика Российской Федерации" и в целом эффективность цифровых преобразований экономики России. Обращается внимание на необходимость выработки целевой государственной политики и адаптивных механизмов регулирования в сфере национальной инфраструктуры телекоммуникаций.
La administración pública desde la perspectiva de la prevención de atrocidades en las respuestas a la COVID-19: Aprovechar la pandemia para lograr mayor equidad social
Authors:   SUNY Binghamton, Rubaii Nadia , Whigham Kerry E. ,   Rutgers University, Appe Susan ,   Rockefeller College of Public Affairs & Policy
Published: December 2021

The pandemic is already forcing many individuals, businesses, and governments to rethink much of what they do and how they do it. As such, it presents an opportunity for public administrators to reimagine the criteria they use when designing and implementing programs and policies, and to more actively engage in prevention of identity-based violence. In this contribution, we suggest a new analytical lens to guide public administrators’ decision making, one informed by the theory and practice of mass atrocity prevention. This perspective recognizes that the decisions and actions of public administrators in response to the pandemic will influence whether individual countries and the global community writ large will be at increased risk of mass atrocities or if they will be more resilient and better positioned to prevent such atrocities. The COVID-19 pandemic represents both an imperative and an opportunity to reduce risks of mass atrocities, and public administrators have a vital role to play in this process.
Formulation and Evaluation of Nutraceutical Tablet Using Clove Drugs by Wet Granulation Method
Authors: Swapnali Kawade
Published: December 2021

Abstract: The objective of present study was to formulate and evaluate the nutraceutical tablets with different combination of herbal drugs. Material and Method: The nutraceutical tablet containing lactose and mannitol as diluent and containing natural drugs like clove and cinnamon which was prepared by direct compression method. The compressed formulations were subject to several evaluation parameters like appearance, thickness, weight variation, hardness and friability. Results: The results of all evaluation parameters of nutraceutical tablet were within the acceptable limit. Pre-compression studies of nutraceutical tablet show satisfactory results. The thickness, hardness, weight variation, and friability of nutraceutical tablet were found to in acceptable range. The in-vitro drug release of eugenol from optimised nutraceutical formulation was found to be 90.23%. Significant results were obtained from present study. Discussion: The finding of current investigation clearly found that the health promotion of the body could be done by nutraceuticals. Keywords: Direct compression, Nutraceutical, Eugenol, In-vitro drug release
Designing a Vehicle Collison-Avoidance Safety System using Arduino
Authors: Metar Manas
Published: December 2021

Abstract: The future of automotive relies on the mechatronic and electronic systems. The worldwide growth of automotive towards electronic systems suggests that driverless cars would soon be the common commuters. With such improvements safety of the passengers becomes first priority for the manufacturers. Nowadays automobiles come with high end technologies and quick responsive electronic systems. In addition to the passive safety systems, active safety systems definitely avoid collision thereby reducing the chances of injury and death. This project shows the working of an active safety system that is collision avoidance system. To create the model, TINKERCAD software has been used and a detailed working is explained. As a result, the system detects traffic and can alert the driver and stop the vehicle before meeting the collision. Keywords: Active Safety System, Arduino, Tinkercad, Vehicle Electronics System, Automotive Safety System, Collision Avoidance System, Self-Driving Car, Driverless Vehicle.
A COMPACT AND PORTABLE DESIGN DEVELOPMENT OF A LOW ROLLING RESISTANCE TEST RIG
Authors: Wheatley Greg , Rains Ashley , Zaeimi Mohammad
Published: December 2021

Low Rolling Resistance (LRR) conveyor systems are generally preferred over traditional conveyors because of better overall efficiency lesser energy consumption required to operate. In this work, the design development and analysis path in the process of downscaling the size of an existent LRR test rig to a compact, portable and desktop-sized model is presented. Simulation has been developed using SolidWorks and finite element analysis is conducted using ANSYS to obtain the deformation, stress and strain of each part of the new design.
SALES FORECAST FOR AGGREGATE PLANNING: CASE STUDY OF AN INDUSTRIAL PRODUCTS COMPANY IN MEXICO
Authors: Alvarez Placencia Ignacio , Sánchez-Partida Diana , Martínez-Flores José-Luis , Cano-Olivos Patricia
Published: December 2021

This case study presents the analysis through the use of sales estimation tools for planning demand for aggregate level as a finished product in a leading industrial products company in the market in Mexico. First, it aligned the demand plan and the supply plan, recommending the best execution scenario to increase operational efficiency and reduce the cost of operating the supply chain to increase the company's productivity and stay competitive. Then, after analysing the behaviour of the demand for selected products, the authors determined as the main affectation the inadequate precision of the method forecasting and the lack of an aggregate forecasting strategy that allows reducing the variation. Due to this, the most significant effort was concentrated on determining a better-forecasting model and the decision to aggregate the demand based on three relevant criteria: the demand pattern based on the Soft, Intermittent, Erratic or Irregular quadrant, the best method of the forecast for each product and the time in quarters. As a result, a reduction between 20% and 46% in the forecast variation can be obtained from the above.