bluuebunny/crossref_metadata_2025 huggingface dataset:
KAJIAN POLA WACANA KEKERASAN DAN USAHA PREVENTIF SERTA ANTISIPATIF MENGATASI PERKELAHIAN PELAJAR
Authors: SRI SUKARDI JOKO
Published: March 2022

A competetion an cooperation are two different things hut they should be able to be combined in developing the social life of school, for the competetion tends to bring about the potential growth of conflict sources. The Conflict on a result of the school informal symbols is in the contrary to the school forrnul symbols. The preventive and anticipulive effort if it has been implemented by the school, is necessary to he continued for socialization. The cumpetefion among the schools can be modified to be a cooperation, in which each school with patenfial students is joined with other school Potential student to have a training together, so that it seems there is no competition, but show more in cooperation.
PENDIDIKAN NILAI SEBAGAI KOMPONEN INTEGRAL PENDIDIKAN UNTUK MENGHADAPI TANTANGAN ABAD XXI
Authors: PRIYOYUWONO PETRUS
Published: March 2022

The purpose of education is in fact to improve the quality of one's life. Without ruling out the benefit and economic purposes, education has produced present generation with the most in number of experts and trained workers who makes fast progress within the science, knowledge and technology. even though in its process, mankind's interest, cultural and ethical values are often ignored The components of value education need to be put in the curriculum at different school level using various strategies. The value education is a task and responsibility of schools as well as parents.
PENDIDIKAN KEWARGANEGARAAN SENSITIF BUDAYA
Authors: Suyato Suyato
Published: March 2022

Tulisan ini bertujuan untuk menggagas model Pendidikan Kewarganegaraan (PKn) yang sensitif terhadap keberagaman budaya sebagai alternatif model mainstream yang banyak dianut saat ini, yang dicirikan oleh pendekatan top-down, one-size-fits-all. Penulis berargumentasi bahwa pengembangan model PKn sensitif budaya diperlukan dalam rangka mengakomodasi tuntutan perkembangan masyarakat di era global, dimana seiring dengan proses globalisasi muncul gerakan berupa penyadaran kembali ke budaya asli atau proses yang lebih dikenal sebagai glocalization. Permasalahan yang dibahas dibatasi pada teori-teori yang bisa digunakan sebagai landasan pengembangan model Pendidikan Kewarganegaraan yang dapat menghasilkan warga negara yang locally embedded, globally connected. Berdasarkan kajian pustaka, ada dua kelompok besar teori yang dibahas, yaitu teori yang dikemukakan Cheng (2005) tentang pemberdayaan pengetahuan lokal dalam rangka menghadapi arus globalisasi dan Teori-teori tentang cosmopolitanism. Berdasarkan dua kelompok teori tersebut, disajikan saran praktis berkaitan dengan model Pendidikan Kewarganegaraan.Kata kunci: Kepekaan lintas budaya, Pendidikan kewarganegaraan
APLIKASI TEORI BELAJAR KONSTRUKTIVISME DALAM PEMBELAJARAN BAHASA ASING
Authors: Ningsih Ningsih
Published: March 2022

Sebagai sarana komunikasi, bahasa memegang peranan penting dalam kehidupan juga dalam kelas. Namun dalam kegiatan kelas, siswa sering merasa sulit untuk memahami teks, karena topik baru yang dibawa oleh guru tidak memiliki keterkaitan dengan pengetahuan mereka sebelumnya. Konstruktivisme adalah pendekatan yang menunjukkan bahwa pembelajaran lebih efektif dan bermakna ketika siswa mampu berinteraksi dengan masalah atau konsep. Contoh pembelajaran dengan menggunakan prinsip teori belajar konstruktivisme adalah gagasan pembelajaran bahasa kolaboratif, pembelajaran berbasis proyek, pembelajaran berbasis tugas dan permainan peran. Kata Kunci: Konstruktivisme, Teori belajar, Bahasa asing
PENANAMAN NILAI-NILAI NASIONALISME MELALUI KEARIFAN LOKAL PARA BURUH MIGRAN DI HONG KONG
Authors: Rukiyati Rukiyati , Hajaroh Mami , Purwastuti Lusila Andriani
Published: March 2022

Para buruh migran yang bekerja di Hong Kong perlu diberi motivasi dan wawasan keindonesiaan dan rasa nasionalisme agar mereka bekerja dengan tekun tetapi mempunyai target yang jelas untuk kembali ke tanah air. Pemberian motivasi dan wawasan dilakukan dengan media kearifan lokal Indonesia berupa pengenalan kembali dan menyanyikan lagu-lagu tradisional, dan  lagu wajib serta memasak makanan tradisional Indonesia. Peserta pelatihan ini adalah para buruh migran yang tergabung dalam organisasi nirlaba TCKLC Hong Kong sebanyak 25 orang, kesemuanya perempuan. Metode PPM yang digunakan adalah ceramah singkat, diskusi, penugasan, praktik, dan bernyanyi. Hasil kegiatan PPM menunjukkan para buruh migran sangat senang menerima pelatihan penanaman nilai-nilai nasionalisme melalui kearifan lokal. Diperoleh kesadaran dari para buruh migran bahwa walaupun di Hong Kong mereka mendapatkan penghasilan yang cukup besar, tetapi tetap merasa sebagai kurang bermartabat, kurang terhormat. Setelah pelatihan,para buruh migran merasa sangat termotivasi untuk pulang ke tanah air dengan  rencana yang jelas untuk pekerjaan dan kegiatannya masing-masing. Bekal dari Hong Kong berupa uang akan dimanfaatkan untuk usaha dan sekolah,  sedangkan bekal ilmu akan digunakan untuk bekerja menjadi guru di daerahnya masing-masing. Lima bulan setelah pelatihan, diperoleh informasi sebagian buruh migran yang telah selesai masa kontraknya benar-benar telah kembali ke tanah air dan bekerja sesuai rencana ketika pelatihan. Ada yang menjadi guru PAUD, guru bahasa Inggris, melanjutkan pendidikan, dan ada pula yang berwirausaha. Kata kunci: Nilai nasionalisme, buruh migran, kearifan lokal
Self-directed learning readiness of automotive body repair student to face 4.0 learning system
Authors: Pratama Atmoko Putra , Sofyan Herminarto , Yudianto Aan
Published: March 2022

This study aims to reveal: 1.) Readiness of independent learning of vocational students in the department of automotive body repair to face 4.0 learning systems; and 2.) Supporting and inhibiting factors of students in implementing a 4.0 learning system. This study uses a descriptive-analytical method with a case study approach. The subject consisted of students and teachers of vocational high school majoring in automotive body repair. Data collection techniques in this study were observation, interviews, and questionnaires. The research was conducted at SMK N 2 Depok Sleman, automotive body repair engineering department. 30 respondents filled out the questionnaire to assess the level of self-directed learning readiness of respondents according to SDLR. The readiness level of self-directed learning is divided into three categories: low, medium, and high. The results of this study are (1) Readiness of students majoring in automotive body repair techniques in the face of learning systems 4.0 is included in the medium category, and (2) The supporting and inhibiting factors found in dealing with learning systems 4.0 come from internal and external of the student learning environment.
Employability skills of state vocational high school students on welding engineering expertise competency
Authors: Areisy Hafiidhiya Janata , Sudira Putu
Published: March 2022

This study aims to: 1.) Describe the mastery level of employability; and 2.) Find out the order of mastery of the employability skills of vocational high school (VHS) students. This study was a survey research with quantitative approach. The research was conducted at a vocational high school in Madiun Regency with A accreditation. Data collection instrument was a questionnaire that had been tested for content validity by the experts. The construct validity test used the product-moment formula and was declared valid. The results that 56 items were declared valid and reliable. The questionnaire was given to 149 students of class XII of welding engineering expertise competency. Data were analyzed using descriptive statistical analysis technique. The results of the study are as follows: 1.) The mastery level of employability skills is in the high category with the mean score 168.61 greater than the ideal mean score of 132.5; and 2.) The order of mastery on aspects of employability skills, from the highest to the lowest achievement using technology skill, keeping occupational health and safety skill, learning skill, self-management skill, initiative and enterprise skill, planning and organizing skill, communication skill, and problem-solving skill.
Mapping professional competency for teachers’ productive arts and culture of vocational school
Authors: Susatya Edhy , Mahmudah Fitri Nur , Budhiasih Rubiati
Published: March 2022

The purpose of the study was to analyze the educational background, the suitability of teacher competence or linearity, and map the professional competence of productive teachers in the vocational school of arts and culture. This research is descriptive qualitative research. The research stages are; collecting information related to teacher educational background, education and training data, and interviews. The research subjects were school principals, administrative heads, and teachers. The evaluation uses the discrepancy model. The research population is principals and productive teachers of the vocational schools of arts and culture. Data collection techniques using observation, interviews, and documentation. Data validation uses source triangulation and collection. Data analysis used descriptive techniques and simple mathematical analysis. The results showed that: (1) The educational background of productive teachers; dance, musical arts, theater arts, and puppetry arts 96,67% in accordance with the legal basis set by the Ministry of Education and Culture of the Republic of Indonesia; (2) The suitability of the competence or linearity of productive teachers according to learning materials in vocational high school; and (3) A map of professional competence for productive teachers; dance, musical arts, theater arts, and puppetry are 30% of teachers in the mastering category and 70% in the very mastered category. Based on passport skills, it is recommended that 8 (26,67%) teachers attend secondary level training, 9 (30%) teachers attend advanced training, and 13 (43,33%) teachers attend advanced level training. The results of the study are recommended for consideration by the relevant agencies in making policies, recruiting, improving the quality of teachers, determining teaching tasks, teaching burdens, and developing teacher coaching models.
Web-Based Software Tools for Systematic Literature Review in Medicine: Systematic Search and Feature Analysis
Authors: Cowie Kathryn , Rahmatullah Asad , Hardy Nicole , Holub Karl , Kallmes Kevin
Published: March 2022

Background

Systematic reviews (SRs) are central to evaluating therapies but have high costs in terms of both time and money. Many software tools exist to assist with SRs, but most tools do not support the full process, and transparency and replicability of SR depend on performing and presenting evidence according to established best practices.

Objective

This study aims to provide a basis for comparing and selecting between web-based software tools that support SR, by conducting a feature-by-feature comparison of SR tools.

Methods

We searched for SR tools by reviewing any such tool listed in the SR Toolbox, previous reviews of SR tools, and qualitative Google searching. We included all SR tools that were currently functional and required no coding, and excluded reference managers, desktop applications, and statistical software. The list of features to assess was populated by combining all features assessed in 4 previous reviews of SR tools; we also added 5 features (manual addition, screening automation, dual extraction, living review, and public outputs) that were independently noted as best practices or enhancements of transparency and replicability. Then, 2 reviewers assigned binary present or absent assessments to all SR tools with respect to all features, and a third reviewer adjudicated all disagreements.

Results

Of the 53 SR tools found, 55% (29/53) were excluded, leaving 45% (24/53) for assessment. In total, 30 features were assessed across 6 classes, and the interobserver agreement was 86.46%. Giotto Compliance (27/30, 90%), DistillerSR (26/30, 87%), and Nested Knowledge (26/30, 87%) support the most features, followed by EPPI-Reviewer Web (25/30, 83%), LitStream (23/30, 77%), JBI SUMARI (21/30, 70%), and SRDB.PRO (VTS Software) (21/30, 70%). Fewer than half of all the features assessed are supported by 7 tools: RobotAnalyst (National Centre for Text Mining), SRDR (Agency for Healthcare Research and Quality), SyRF (Systematic Review Facility), Data Abstraction Assistant (Center for Evidence Synthesis in Health), SR Accelerator (Institute for Evidence-Based Healthcare), RobotReviewer (RobotReviewer), and COVID-NMA (COVID-NMA). Notably, of the 24 tools, only 10 (42%) support direct search, only 7 (29%) offer dual extraction, and only 13 (54%) offer living/updatable reviews.

Conclusions

DistillerSR, Nested Knowledge, and EPPI-Reviewer Web each offer a high density of SR-focused web-based tools. By transparent comparison and discussion regarding SR tool functionality, the medical community can both choose among existing software offerings and note the areas of growth needed, most notably in the support of living reviews.
A Crowdsourcing Open Contest to Design a Latino-Specific COVID-19 Campaign: Mixed Methods Analysis
Authors: Shah Harita S , Dolwick Grieb Suzanne , Flores-Miller Alejandra , Phillips Katherine H , Page Kathleen R , Cervantes Ana , Yang Cui
Published: March 2022

Background

Latino communities are among the most heavily impacted populations by the COVID-19 pandemic in the United States due to intersectional barriers to care. Crowdsourcing open contests can be an effective means of community engagement but have not been well studied in Latino populations nor in addressing the COVID-19 pandemic.

Objective

The aims of this study are to (1) implement and evaluate a crowdsourcing open contest to solicit a name for a COVID-19 social marketing campaign for Latino populations in Maryland and (2) conduct a thematic analysis of submitted entries to guide campaign messaging.

Methods

To assess the level of community engagement in this crowdsourcing open contest, we used descriptive statistics to analyze data on entries, votes, and demographic characteristics of participants. The submitted text was analyzed through inductive thematic analysis.

Results

We received 74 entries within a 2-week period. The top 10 entries were chosen by community judges and the winner was decided by popular vote. We received 383 votes within 1 week. The most common themes were collective efficacy, self-efficacy, and perceived benefits of COVID-19 testing. We used these themes to directly inform our social marketing intervention and found that advertisements based on these themes became the highest performing.

Conclusions

Crowdsourcing open contests are an effective means of community engagement and an agile tool for guiding interventions to address COVID-19, including in populations impacted by health care disparities, such as Latino communities. The thematic analysis of contest entries can be a valuable strategy to inform the development of social marketing campaign materials.
A Brief Analysis of the Aesthetic Effect of Wu Nong Soft Language in Lu Wenfu’s Novels
Authors: Fengjing Wang
Published: March 2022

When lu Wenfu, a contemporary writer, began to write novels in the 1950s, he set his foot in suzhou, an ancient and deep modern city. His novels focus on the characters in suzhou’s alleys, winding and quiet alleys, with the most ordinary ordinary people as the protagonist, so he is called “Lu Suzhou”. “Wunong Soft language” is one of lu Wenfu’s ways of expressing the regional culture of Suzhou, and “Wunong soft language” is just a symbol of suzhou people’s elegance and gentleness. The wu dialect reflect the softness and delicacy of Suzhou people incisively and vividly. It has a unique aesthetic effect.
The Portrayal of Women in Shiga Literature from the Perspective of “Intersexuality”
Authors: Linmei Zuo
Published: March 2022

Bisexuality is an ancient concept introduced into literature by Virginia Woolf in the 1920s, which breaks through the traditional framework of gender dichotomy and reaches a new level of feminism. According to Woolf’s idea of bi-sexuality, the greatest minds are bi-sexual, i.e., masculine and feminine in one body at the same time. Shiga has long been regarded as Japan’s “god of fiction”, a man whose delicate and vivid writing, concise and powerful language has produced many classic works of literature and literary images. Throughout his life, the theme of women has been a major theme in Shiga’s literary output. In modern Japanese society, which was centred on a patriarchal culture, women were one of the most oppressed groups. This paper focuses on the intersexual consciousness of the female characters in Shiga Naoya’s literature, a study that has profound implications for modern women’s awakening to their own consciousness in the face of gender inequality.
Stigma
Authors: - Anon
Published: March 2022

None
DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF METFORMIN, SAXAGLIPTIN, AND DAPAGLIFLOZIN
Authors: KONDETI HARITHA PAVANI , SANKAR DANNANA GOWRI
Published: March 2022

Objective: A new combination of Metformin, Saxagliptin, and Dapagliflozinfixed-dose combination of antidiabetic medication is being used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
Methods: Chromatography was carried out using Kromasil C18 250×4.6, 5.0 mm column with a flow rate of 1.0 ml/min. The mobile phase comprised of pH 4.8 0.01 N Potassium dihydrogen phosphate buffer and Acetonitrile in the ratio of 65:35 is used. The developed method has been validated for various parameters such as precision, accuracy, linearity, robustness, limit of detection (LOD), limit of quantification (LOQ), and solution stability. The stability-indicating capability of the method was established by forced degradation studies under stress conditions such as acid, base, peroxide, UV, thermal, and humidity.
Results: The retention times of Metformin, Saxagliptin, and Dapagliflozin were found to be 2.294, 2.869, and 3.887 min, respectively. The method was specific and linear (R2>0.999) for MET, SXG, and DGF. The LOD and LOQ were found to be 13.85 μg/ml and 41.95 μg/ml for MET, 0.06 μg/ml and 0.19 μg/ml for SXG and 0.19 μg/ml and 0.57 μg/ml for DGF, respectively. The mean % recovery obtained was found to be 100.21% for MET, 99.83% for SXG, and 99.97% for DGF, respectively.
Conclusion: Hence, the chromatographic method developed was said to be rapid, simple, specific, sensitive, precise, accurate, robust, and reliable that can be effectively applied for routine analysis in research institutions, quality control departments in industries.
IDENTIFICATION OF ETHR INHIBITOR TARGETING MYCOBACTERIUM TUBERCULOSIS: AN INSIGHT FROM MOLECULAR DOCKING STUDY
Authors: POLEBOYINA PAVAN KUMAR , C PAWAR SMITA
Published: March 2022

Objective: Mycobacterium tuberculosis (MTB) is a pathogenic bacterium of the Mycobacteriaceae family that causes TB. EthR is a transcriptional regulator which is involved in the repression of the monooxygenase EthA which is responsible for the formation of the active metabolite of Eth. Inhibitors of the EthR DNA binding protein induce a conformational change in this repressor, thus preventing its binding to DNA operator, consequently resulting in increased transcription of EthA and bioactivation of Eth.
Methods: In this study, we used first-line and second-line drugs and their analogues to validate the binding affinity of EthR DNA binding protein of MTB. Molegro Virtual Docker (MVD) is utilized for virtual screening and validation of MolDoc, Rerank, and hydrogen bond parameters of ETH, isoniazid (INH), clofazimine (CLF), and its modified derivatives to the EthR DNA binding protein of MTB. The modified molecules; ETH4, INZ2, CLF3, and CLF4 show more binding affinities than that of native compounds ETH, INH, and CLF to the EthR DNA binding protein of MTB. The top scoring compound was docked by auto dock vina in PyRx to get the best conformer pose for intermolecular interactions.
Results: CLF4 had the best lowest MolDock score -176.29kcal/mol and H-bonding energy -6.89kcal/mol in the MVD virtual screening. The best conformer pose generated by PyRx was shown -7.1 binding affinity and ligand generated hydrogen bond interactions with THR130 and LYS68, respectively, which stabilized the ligand in the active site of EthR protein.
Conclusion: We concluded that CLF4 has shown better inhibitory efficacy than other compounds towards EthR protein. However, these results need to be further substantiated through in vitro and in vivo experimental studies.
ASSESSMENT OF PSYCHOSOCIAL CONSEQUENCES OF COVID-19 IN DIABETES PATIENTS: A CROSS-SECTIONAL STUDY
Authors: G JOSHI DHARITRI , JAYAN ASWATHY , GEORGE SHARA , UMMACHAN NISSYMOL , SARA KURIAN RICKEY
Published: March 2022

Objective: The aim of the study was to assess the psychosocial health, to identify coronavirus disease 2019 (COVID-19) specific concerns in people with diabetes and to analyze the changes in the management of diabetes during the corona crisis.
Methods: An online cross-sectional survey was conducted for a period of 6 months among the South Indian diabetes population. A validated questionnaire containing socio-demographics, general health status, the diabetes distress scale 17, and the 3-itemUCLA loneliness scale was sent to 600 people, out of which 226 participants were included in the study based on inclusion and exclusion criteria. Responses were analyzed using univariate and multivariate logistic regressions.
Results: Among the participants, females had moderate to high diabetes distress (54.4%). The subjects in the age group of 40–59 years felt lonely and had more diabetes distress. The two major worries among the participants were that “they are labeled as a risk group” and that “they might be overly affected.” Participants with gestational diabetes mellitus (DM), DM duration of 7 months to 1 year, taking both medications (oral antidiabetic medication and insulin), HbA1c level of more than 8%, infected with coronavirus or having someone close to them infected with coronavirus, were more concerned about taking medication daily, and those who changed their meal plan during the corona period had the greatest concerns.
Conclusion: People who participated in the survey were more worried about the COVID-19 situation and were very disturbed. Psychosocial consequences of COVID-19 were more prevalent in diabetes patients, including diabetes distress, loneliness, and changes in daily diabetes management.
PREVENTION OF DNA SUGAR, HUMAN PERIPHERAL LYMPHOCYTES AND ERYTHROCYTES DAMAGES FROM FREE RADICAL INDUCED OXIDATION BY NATURAL ANTIOXIDANTS
Authors: NG OMKAR , G PREM KUMAR , V BHAGYALAKSHMI , RAMADAS DINESHA
Published: March 2022

Objective: The present study focused on the identification of particular extract which shows signification protection of DNA sugar against excessive oxidation.
Methods: The different extracts (water, alcohol, alcohol: water, and hexane) of Agathi seeds (Sesbania grandiflora Linn) were evaluated using various antioxidant and other relevant assays like DNA sugar protection and antioxidant activities.
Results: The alcohol: water (1:1) extract of S. grandiflora Linn seeds showed the highest antioxidant and free radical scavenging activity. It inhibited membrane lipid peroxidation by 55% at 50 μg/ml, scavenged approximately 69% of hydroxyl and 1,1-diphenyl-2-picrylhydrazayl radicals at 2–3 fold lower concentrations compared to the other extracts. In addition, the alcohol: water extract inhibited ferrous sulfate: ascorbate-induced sugar oxidation of DNA and also showed non-toxic nature against lymphocytes.
Conclusion: These results establish the antioxidant potential of the extract, which could be used as natural antioxidant source.
CLINICO-CYTOLOGICAL AND HISTOPATHOLOGICAL CORRELATION OF LYMPHADENOPATHY IN PEDIATRIC PATIENTS
Authors: MAHAJAN RIYA , SINGAL POONAM , KUNDAL SHIVANSHU , SINGH HARJINDER , KUNDAL RAMESH KUMAR , MONGA PRIYASI
Published: March 2022

Objective: The aim of the present study was to evaluate the cytomorphological and histopathological (wherever possible) patterns of lymph node (LN) lesions along with clinical correlation in the pediatric population.
Methods: This was a prospective study conducted on 100 pediatric patients (aged <12 years) who presented with lymphadenopathy (LAP). Fine-needle aspiration cytology (FNAC) was performed on all cases out of which only 22 underwent surgical excision and histopathological examination. Aspirated material was stained with May-Grunwald Giemsa, Papanicolaou, Z-N stain (wherever required) and for histopathology, Hematoxylin and eosin stain was used.
Results: Majority number of patients was in the age group of 5–8 years (44%). Cervical LN s were most commonly involved (71%). Out of the total 100 cases, 91% were benign, 3% were malignant and 6% were inadequate. Most common cytologically diagnosed entity was non-specific reactive lymphadenitis (68%). There was one case of reactive lymphadenitis on cytology that proved to be Hodgkin lymphoma on histopathology. Two cases of generalized LAP given as atypical lymphoproliferative lesion on cytopathology proved to be acute lymphoblastic leukemia/lymphoma on further investigation. The cytomorphological findings were found to be concordant with histopathology in 21 cases out of 22 with a diagnostic accuracy rate of 95.45%.
Conclusion: FNAC is especially helpful as LN biopsy is a difficult and invasive procedure in children. Although excision biopsy is the gold standard, FNAC is preferred as first-line investigation. Along with cell block analysis and ancillary techniques, it provides an excellent diagnostic accuracy.
PHYTOCHEMICAL PROFILING, HPTLC FINGERPRINT AND ANTIBACTERIAL, ANTI-FUNGAL, AND ANTIOXIDANT PROPERTIES OF ESSENTIAL OILS EXTRACTED FROM CUMMINUM CYMINUM, ZINGIBER OFFICINALE, TRACHYSPERMUM AMMI, ALIPNIA GALANGA, CEDRUS DEODARA, AND ELETTARIA CARDAMOMUM
Authors: P GURUVAURAPPAN , SAHOO MANAS RANJAN , VARIER RAMESH RAGHAVA , RAJENDRAN ANITHAKUMARI , HAREKRIHSN MAHESWARI , KARUPPASAMY RAMESH , S SRIKRISHNA
Published: March 2022

Objective: The objective of the study was to carry out the phytochemical profiling of essential oils (EOs) and evaluation of their anti-microbial activity. Methods: The EOs extracted from Cumminum cyminum, Zingiber officinale, Trachyspermum ammi, Alipnia galanga, Cedrus deodara, and Elettaria cardamomum using clavenger apparatus. Phytochemical analysis and high-performance thin layer chromatography (HPTLC) fingerprinting were carried out for the EO. The antibacterial and antifungal activity were evaluated using agar well-diffusion method against two bacterial strains, Escherichia coli, Staphylococcus aureus and two fungal strains, Candida albicans, and Aspergillus brasiliensis. Positive controls ciprofloxacin-30 mg, azithromycin-15 mg, and nystatin NS-50 mg were used. Antioxidant potential of the EOs was investigated by TLC-bioautography method using 1,1-diphenyl-2-picrylhydrazyl derivatization. Results: The phytochemical analysis reveals presence of various phytochemical such as steroids, terpenoids, and phenylpropanoids. The HPTLC fingerprint is found to be unique for each of the oil. The EO of Z. officinale and T. ammi showed strong antibacterial activity against S. aureus. The EOs of C. cyminum, Tachyspermum ommi and A. galanga displayed prominent antioxidant activity on TLC bioautography. The herbs Cuminum cynimun, T. ammi, C. deodara, and Ellateria cardamomum produce reasonable amount of essentials oil, which can be explored for useful their industrial applications. Conclusions: These EOs can be explored further for their antimicrobial activity. The HPTLC analysis along with derivatization with suitable chromogenic reagents can be a rapid and simple tool for quality control of various EOs.
IN SILICO SCREENING AND PREDICTION OF LYCOPODIELLA CERNUA L. AGAINST CRYSTAL STRUCTURE OF DNA GYRASE
Authors: T AMUDHA , S RAJESWARI
Published: March 2022

Objective: The point of the review was centered around hindrance DNA Gyrase by mixtures of Lycopodiella cernua L., a perpetual plant through in silico studies.
Methods: The Chemical mixtures of the plant test was gathered from the L. cernua L. Molecules that fall inside Lipinski’s standard of five such particles are frequently distinguished and finished for docking. The natural action of the mixtures was dissected utilizing the pass online device. The worth of Probability to be dynamic (Pa) and idle (Pi) are investigated. The few mixtures recovered from the plant were examined for its conceivable critical cooperation with the objective protein utilizing sub-atomic docking studies.
Results: The compound 2-Ethylacridine had G-Score of - 7.1 Kcal/mol and framed hydrogen bonds with the buildup GLY showing the bond length of 2.0. The future point of view of the review is to decide the strength of the protein-compound complex through elements studies. The connections were noticed utilizing Pymol.
Conclusion: The came about compound showed higher adequacy than controlled (anti-microbial) compound, this demonstrates the plants potential to be a successful medication compound towards the objective. The plant mixtures ought to be investigated more to be an effective and potential medication particles.
EMULGEL EMERGENT SYSTEMS: AT A GLANCE FOR TOPICAL DRUG DELIVERY
Authors: VISHWAKARMA GIRJESH , SINGH PANWAR AAKASH
Published: March 2022

Emulgels have been emerged both in cosmetics and pharmaceutical preparations. When gel and emulsion are used in the combined form, they are referred to as Emulgel. Emulgel is a promising drug delivery system for the delivery of hydrophobic drugs. Emulgel is an emulsion that is gelled by mixing it with gelling agents. Many advantages of gels have the major limitation of delivery of hydrophobic drugs. Hence, the emulsion-based approach is being used to overcome this limitation. Emulgel is an interesting topical drug delivery system as it has a dual release control system, i.e., gel and emulsion. The use of gels and emulsions as combined dosage form results in the formation of emulgel showing dual release. With this approach, polymers with enhanced effect in release patterns have emerged, providing sustained and controlled release. They are generally applied for antiseptics, antifungal agents, skin emollients, and protectants. The activity of topical preparation confides in various factors such as drug solubility, lipophilicity, contact time to the skin, and permeability. Emulgels have numerous advantages in dermatology, such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, nonstaining, long shelf life, bio-friendly, transparent and pleasing appearance. Emulgel is being used to deliver analgesics, anti-inflammatory, antifungal, anti-acne drugs, and various cosmetic formulations with a wide range to explore.
ACUTE EFFECTS OF SMOKING ON VENTRICULAR REPOLARIZATION
Authors: PRASAD DOMALA , GNANADURAI THILIP KUMAR , P SHANMUGARAJU
Published: March 2022

Objective: Cigarette smoking, modifiable and preventable risk factor of death due to cardiovascular changes globally. As the frequency increases, this alters the ventricular repolarization and sympathetic tone lead to ventricular arrhythmogenesis. The aim and objective of the study are to evaluate the effects of smoking (before and immediately after smoking) on ventricular repolarization by recording the Tp-e interval, Tp-e/QTc ratio by using an electrocardiogram, since it is an accurate, less expensive, and non – invasive tool.
Methods: Around 40 healthy male volunteers who are smokers aged between 18 and 25 years were recruited in this study. All subjects were non-alcoholics, non–tobacco chewers took no drugs, and had a uniform pattern of diet and activity. The acute effect of smoking on the heart was determined by measuring the electrocardiographic parameter before and immediately after smoking a king-size cigarette.
Results: The analysis showed that there was a statistically significant increase in heart rate immediately after smoking compared to baseline values in smokers. TP interval and Tp-e interval were increased immediately after smoking and were highly significant.
Conclusion: Our study has proven that there was a remarkable change in cardiac activity immediately after smoking. Tp-e Interval may serve as a better risk factor to predict sudden cardiac arrest in the future especially in chronic smokers. Smoker’s heart is already injured due to its injurious chemicals, adding on to that every new cigarette increases the burden on cardiovascular health. Hence, it is never late to quit smoking rather than suffering from its injurious effect.
PHARMACOEPIDEMIOLOGICAL EVALUATION OF HIV PHARMACOTHERAPY AT DISTRICT ART CENTER IN SOUTH TELANGANA
Authors: B SONALI , G AKHILA , R DIVYA , R ADEPU  , T ANUSHA
Published: March 2022

Objective: Objective of the study was to assess the drug utilization pattern of antiretroviral drugs, and medication adherence behavior among human immunodeficiency virus (HIV) patients attending a local ART center, Suryapet, South Telangana.
Methods: This was a prospective observational study approved by institutional ethics committee. Demographic, clinical, laboratory, and the treatment details were collected on daily basis for new cases and the data add on was collected for old cases. Medication adherence behavior was assessed through Morisky Medication Adherence Scale-8.
Results: During the study period, a total of 505 HIV patients were enrolled. Among them, majority patients were women (61%), in the age group of 31–45 (49.7%). Illiterates (52.6%). Major mode of transmission identified was intimate contact (74%), and majority patients were in Stage I (49%). TLE regimen was prescribed in 69.9% patients and for children the prescribed regimen was ABC, 3TC, EFV (5.1%). About 43% patients were found with medium adherence.
Conclusion: This study concludes that the most prescribed regimens were combination of TLE, and majority of the patients were found with medium adherence.
CASE SERIES - INSULIN INFUSION THERAPY IS EFFECTIVE IN HYPERTRIGLYCERIDEMIAINDUCED ACUTE PANCREATITIS
Authors: DADASAHEB MAINDAD , SUKHADYAL DUHAN , AKHIL NAGPAL
Published: March 2022

Objective: Hypertriglyceridemia (HTG) is responsible for up to 10% of all acute pancreatitis (AP) cases. The objective of this study is to present the effects of insulin infusion therapy in HTG-induced AP.
Methods: We had 11 patients with AP and high triglycerides between June 2020 and January 2021 admitted to Bharati Vidyapeeth Medical College and Hospital in Pune, Maharashtra, India. Following laboratory and imaging evaluations, all patients were treated with insulin infusions and supportive care. Following the achievement of triglyceride (TG) level <1000 mg/dL, patients were given Fenofibrate 160 mg OD and Saroglitazar 4 mg OD. We observed their recuperation during the treatment duration.
Results: Our study included 11 AP patients ranging from 18 to 50 years of age, five men and six females. This group included diverse patient population obese, non-obese, diabetic, and non-diabetic patients. TG values ranged from 2200 to 8000 mg/dL, with a mean of 5345.4±1203.8 mg/dL. There were nine patients with moderate pancreatitis, two with mild pancreatitis, and none with severe pancreatitis. Insulin infusions in the range of 302–1008U were required for 2–4 days. TG dropped 17–41% on the 2nd day of insulin infusion and 59–75% on the 3rd day. In all patients, TG levels fell below 1000 mg/dL after 4 days of insulin infusion, and then they were treated with oral anti-lipid medications. Hospital stay ranged from 9 to 25 days, with a 100% recovery rate.
Conclusion: Insulin infusion can be used to treat HTG-induced AP with minimal risk of complications.
A CROSS-SECTIONAL STUDY OF ANTIHYPERTENSIVE DRUG UTILIZATION PATTERN IN RURAL POPULATION OF SOUTHERN INDIA
Authors: DHANIYALA KISHAN , CHANDRA VURIMI BHOPAL , RAYAM SRIHARSHA
Published: March 2022

Objectives: The objective of the study is to study the antihypertensive drug utilization pattern, demographic profile, and associated comorbid conditions of hypertensive patients in the rural population of Southern India.
Methods: This study was a cross-sectional, community-based, door-to-door survey of hypertensive patients. The details of the patients which include age, sex, body mass index (BMI), past medical history, usage of drugs for hypertension (HTN), any other related drugs, and comorbid conditions were collected in this study.
Results: As per the results, the mean age of study participants was 54.68 years, men were 62.31% women were 37.68%, mean BMI was 30.48 kg/m2. In associated comorbidities with HTN, Diabetes was the most common with 19.4%. As per usage of antihypertensive drugs, In Monotherapy, angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) occupy 16.4% followed by beta-blockers (BB) 13.4%.In 2+ drug therapy, Diuretics were 26.8% followed by BB 22.7% and in drug combinations, the combination of ACE/ARB + Diuretics were 11.5% followed by ACE/ARB + calcium channel blocker at 8.2%.
Conclusion: HTN was more common in Men and the BMI was also on the higher side in hypertensive patients. In associated comorbidities with HTN, Diabetes was the most common disease. Antihypertensive drugs usage pattern shows that in monotherapy, ACE inhibitors/ARBs were the most commonly used drugs. In 2+ therapy, the most common add-on drugs were diuretics. In combination therapy, the most common combination was ACE/ARB + Diuretics.
A PROSPECTIVE COMPARATIVE STUDY ON LOCALLY ADVANCED RECTAL CARCINOMA TREATED WITH PRE-OPERATIVE SHORT-COURSE RADIOTHERAPY VERSUS LONG-COURSE RADIOTHERAPY WITH CONCOMITANT CHEMOTHERAPY
Authors: BISWAS LINKON , MAJI AVIK , SHARMA SHYAM , MANDAL SRIKRISHNA
Published: March 2022

Objective: In locally advanced non-metastatic rectal carcinoma, pre-operative radiotherapy is an acceptable alternative over post-operative radiation to improve locoregional control after radical surgery. There are two regimens of pre-operative radiotherapy – short-course radiotherapy (25 Gy/5 fractions/1 week) and long-course chemoradiotherapy (CRT) (50.4 Gy/28 fractions/5.5 weeks). Our study aimed to compare the pathological response, margin negative surgery rates, and treatment-related acute toxicities between these two approaches.
Methods: Patients with histologically proven locally advanced, non-metastatic rectal adenocarcinoma were randomized into study group and control group – the study group received short-course radiotherapy (25 Gy/5 fractions/1 week) followed by surgery after 7–10 days of completion of radiotherapy and the control group received long-course radiotherapy (50.4 Gy/28 fractions/5.5 weeks) with concurrent capecitabine followed by surgery after 4–6 weeks of completion of radiotherapy. Histopathology reports were studied in both groups for the determination of pathological response of tumor and surgical margin status. All patients received adjuvant chemotherapy for 6 months with oxaliplatin and capecitabine. For the assessment of treatment-related acute toxicities, patients were examined during the entire course of treatment.
Results: Overall pathological response (complete response+partial response) was 81.25% in the study arm and 86.66% in the control arm. Complete response rate was 15% in the study arm and 25% in the control arm. Margin negative surgery rates were higher in long-course CRT than short-course radiotherapy (90% vs. 82%), but it was statistically insignificant. Radiation-induced acute skin reactions (less than Grade 2) were significantly higher in long-course CRT arm (p=0.003).
Conclusion: There is no significant difference between pre-operative short-course radiotherapy and long-course concomitant CRT in terms of efficacy and acute toxicity profile. Thus, with our limited resources and huge patient load, short-course radiotherapy can be used as an acceptable alternative to long-course CRT.
ASSESSMENT OF DEPENDENCY-ASSOCIATED FINANCIAL BURDEN OF COVID-19 MORTALITIES
Authors: KULSHRESTHA ALOK , GUPTA GIRJESH , GUMASHTA RAGHVENDRA , KULSHRESTHA MANU , SINGH MAHOR RAJENDRA
Published: March 2022

Objective: The objective of this study was to find out interrelationship of economic burden and dependency profile of families with COVID-19 mortalities and to make related recommendations.
Methods: A mixed method research was conducted to understand the interwoven mechanisms of COVID-19 mortalities for the study of variables including level of education, type of family, and economic burden to guide and direct public health strategies among research vulnerable groups of population in the present and in the future.
Results: The dependency has been high in nuclear and joint family combined (160) as compared to three-generation family (21). The gender-wise distribution shows females having two children in family in higher numbers (46.0%) as compared to males in the same age group (35.5%). There is observed high number of COVID-19 mortalities among graduate and above (79) followed by literate up to higher secondary (60). Mean annual income has been highest in the COVID-19 mortalities for subgroup of a number of children being 4 (5.58%), followed by one child (3.79 lacs), no child (3.11 lacs), two children (2.95 lacs), three children (2.90 lacs), and five and more children (2.79 lacs).
Conclusion: Although there is observed intergroup difference in the gender vulnerabilities and varying threshold of dependencies including social, demographic, economic, and developmental areas, there is an appreciable public health need to achieve social gains and avert possible disparities of existence through intersectoral and envisioned strategic reform-based initiatives leading to gainful coexistence of deprived with other social masses to achieve the set target of social developmental goals as per international health actions.
SECOND TRIMESTER UTERINE RUPTURE WITH PLACENTA PERCRETA IN PREVIOUS LOWER SEGMENT CESAREAN SCAR
Authors: DUBBEWAR AVINASH P , SRIVASTAVA AJAI , KUMAR KATHPALIA SURESH , N HIREMATH RAVISHEKAR , GHODKE SANDHYA , CHOUREY NIRAJ , SREENIVAS AUDUKOORI
Published: March 2022

Rupture of a pregnant uterus is a serious threat to the mother’s life and her unborn child. Most of the reported cases of uterine rupture in scarred uterus are due to dehiscence of previous cesarean scar or a rupture of myomectomy scar and usually occur in the third trimester. Spontaneous uterine rupture in first or second trimester is very rare. Here we report a case of second-trimester spontaneous uterine rupture with a particular emphasis on the etiological factors, discuss the course of events and difficulties in the diagnosis. The lesson learned from this case is that, although uterine rupture is very rare in the second trimester of pregnancy, it should be taken into consideration in the differential diagnosis of acute abdomen, especially if there is a predisposing factor such as previous lower segment caesarean section and fluid in the abdomen.
TO EVALUATE THE MORPHOLOGICAL AND MORPHOMETRIC FEATURES OF ADULT HUMAN CADAVERIC RIGHT LUNG IN NORTH INDIAN POPULATION
Authors: KAUR KULBIR , SINGLA RAJAN KUMAR , SIDHU VANDANA , SHARMA RAVI KANT
Published: March 2022

Objectives: In the present study, different morphological and morphometric features of adult human cadaveric right lungs were observed and noted on the predesigned pro forma. Not much of such measurements have been done in the past. The mean values and standard deviations are calculated. The data thus obtained were tabulated scrutinized, analyzed, and compared with the earlier studies wherever possible. If any variant from the normal is observed, an attempt has been made to explain the same on ontogenic or phylogenic basis.
Methods: The present study has been conducted on 50 adult human cadaveric right lungs obtained from embalmed cadavers, used for dissection in the department of Anatomy, Govt. Medical College, Amritsar, formed the material for the current study.
Results: Majority of the lungs (49 [98%]) were spongy in texture while 1 (2%) lung was firm to touch. It is evident that majority of lungs depicted mottling in the form of black, brown or grey in color in 38%, 28%, and 26% of the specimens, respectively. A complete grey, brown, or brownish black color was seen in 2% lungs each. In one lung yellow mottling was seen which could be because of fat deposition. Length of posterior border (19.9cm) was more as compared to anterior border (17.8 cm). Lungs were measured both along lateral and medial surfaces. Along the lateral surface its mean value was 18.52±3.178 cm (Range 12–25 cm) while along medial surface its mean value was 15.11±2.241 cm (Range 9–23 cm). The mean AP width of right lung at center was 11.05±2.864 cm (Range 7–23 cm) and along inferior border was 13.26±2.743 cm (Range 9–20 cm). The mean mediolateral width was found to be 7.536±2.318 cm with range being 4–15.2 cm.
Conclusion: Knowledge of normal measurements of lungs and their variations may help cardiothoracic surgeons to avoid undue complications during surgery. Furthermore, it may help radiologist to resolve perplexed radiographic findings.
ASSESSMENT OF THYROID DYSFUNCTIONS IN PATIENTS WITH TYPE II DIABETES MELLITUS IN CENTRAL INDIA
Authors: TOMAR MUKESH SINGH , MELWANI VEENA , TRIVEDI ANSHULI
Published: March 2022

Objective: The objective of the study was to assess the prevalence of thyroid disorders among diabetics in Central India.
Methods: This study was conducted as a cross-sectional comparative study at the department of medicine, tertiary care center in Central India on a total of 100 diabetic patients admitted at the study area during the study period of 1 year. Cases in the study group with diabetes and control group (non-diabetic) were enrolled as per inclusion and exclusion criteria in 1:1 ratio. All the patients in both the groups were subjected to the estimation of thyroid function tests, that is, T3, T4, and TSH levels after overnight fasting.
Results: Mean age of patients in the study group was 55.7±10.1 years whereas that of the control group was 53.9±10.6 years. Overall, thyroid dysfunctions were noted in 31% of cases in the study group and 12% of cases in the control group (p<0.05). The most common thyroid dysfunction was hypothyroidism, particularly subclinical hypothyroidism (19% and 8% in the study group and control group, respectively). Thyroid dysfunctions were associated with increased HbA1c in our study group (p<0.05).
Conclusion: Thyroid dysfunctions are observed in higher proportions of cases with diabetes as compared to non-diabetes. All the parameters of thyroid function tests including T3 and T4 levels as well as TSH levels are found to be altered in higher number of diabetics. Poor glycemic control among diabetics is one of the important determinants of thyroid dysfunction in patients with diabetes.