bluuebunny/crossref_metadata_2025 huggingface dataset:
TiO2/Polysulfone Composite Membrane for Enhanced Removal of Acetaminophen from Water
Authors:   Faculty of Chemical Engineering & Technology, Kompleks Pusat Pengajian Jejawi 3, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia, Wan Ramli Wan Khairunnisa , Dollah Norakma ,   Faculty of Chemical Engineering & Technology, Kompleks Pusat Pengajian Jejawi 3, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia, Qing Oon Li ,   Faculty of Chemical Engineering & Technology, Kompleks Pusat Pengajian Jejawi 3, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia
Published: December 2024

There has been a significant rise in the worldwide usage of acetaminophen (ACT), particularly after the COVID-19 pandemic, leading to concerns regarding its possible discharge into the environment. Even at low levels, the gradual buildup of ACT can present a significant risk to both aquatic ecosystems and human health, especially when consumed through drinking water. The advanced oxidation process (AOP) is an excellent treatment technique for removing ACT. However, it is a complex and expensive procedure that consumes a significant amount of energy. Membrane technology has evolved as a viable and efficient method to eliminate ACT, offering a simpler and more energy-efficient approach. This study examined the impact of different concentrations of titanium dioxide (TiO2) nanofiller on the elimination of ACT from a water-based solution. The membrane containing the highest concentration of TiO2 (2 wt.%) demonstrated the greatest water flux and ACT removal rate at 32 L/m2h and 97%, respectively. The inclusion of TiO2 had a substantial impact on the structure of the membrane, leading to the formation of evenly distributed finger-like pores throughout a spongy framework. This modification resulted in enhanced flow rate and increased efficiency in terms of the flux and rejection rate
ENHANCING EQUIPMENT FLEET AVAILABILITY USING GEMBA LEAN TOOL: A CASE STUDY IN HEAVY TRUCK AND TANK TRAILER REPAIR SHOP
Authors:   School of Industrial Sciences and Technology (SIST), University of Central Missouri., K. Doe Dzakator Desire
Published: December 2024

Purpose: The purpose of this paper is to leverage the Gemba lean tool to study and enhance fleet management practices inheavy truck and tank trailer repair shop operations. Gemba, often referred to as the real place where things happen, provides a framework for observing and improving processes directly at the site of operations (Imai, 2016). By applying this approach, the research aims to gather and analyze data on the current fleet management practices at heavy truck and tank trailer repair shop operations and identify areas for improvement. The focus is on examining how fleet availability impacts overall business productivity, especially in a service-repir industry where timely equipment functionality is crucial.

Design/Methodology/Approach: This research is based on primary data collected over an 8-month period using a fleet utilization template. The methodology involves evaluating the extent of fleet utilization and the impact of equipment downtime on the business operations of heavy truck and tank trailer repair shop. The collected data was analyzed to understand the correlation between equipment availability and employee productivity. Additionally, the study examines how maintenance practices-or the lack thereof-affect fleet downtime and, subsequently, the operational efficiency of the business.

Findings: The research findings reveal a clear relationship between equipment availability and employee productivity. In small service repair businesses, maintaining fleet availability is often overlooked, yet it plays a significant role in meeting business objectives. The study found that prioritizing fleet maintenance could significantly reduce equipment downtime, thereby improving fleet availability and enhancing employee productivity. These improvements would help businesses like heavy truck and tank trailer repair shop achieve their strategic goals more effectively, by ensuring that employees have the necessary tools to perform their tasks without interruption. This research highlights the need for management in small businesses to adopt more proactive fleet maintenance strategies to increase productivity and overall operational efficiency.
4(N)-ARYL/ALKYL SUBSTITUTED THIOSEMICARBAZONE DERIVED METAL COMPLEXES, THEIR SPECTRAL AND BIOCHEMICAL STUDIES: A REVIEW
Authors:   Department of Chemistry, Pratap College (Autonomous), Amalner, Dist.-Jalgaon (M.S.) India (Research Scholar at SJJT University, Rajasthan)., Dipke S.S. , Gujarathi J.R. ,   Department of Chemistry, Pratap College (Autonomous), Amalner, Dist.-Jalgaon (M.S.) India (Research Scholar at SJJT University, Rajasthan).
Published: December 2024

N(4)-alkyl/aryl substituted thiosemicarbazones and their metal complexes show significantly enhanced biochemical properties than well-known standard drugs. In this review, we extensively focused on the synthesis, biological applications, and structural characterization of the aforementioned compounds over the past decade. A detailed description of the structures of thiosemicarbazone derivatives substituted at the N(4)-position and their metal complexes is presented here. The structures of the compounds were elucidated with respect to their bonding interactions with metal ions and their geometric configurations. Additionally, the review emphasizes the importance of ligands and complexes by reviewing their biological and analytical applications, such as the newly discovered N(4)-substituted thiosemicarbazones and metal chelates throughout the previous decade. It highlights their potential impact on future research and practical applications.
A CASE OF MIGRAINE TREATED BY USING BTPB REPERTORY
Authors: Pandey Chetna
Published: December 2024

This is the case of a 36 years old female who came with pain in head in occiput region along with blurred vision and weakness. in this case all the symptom was of migraine. after taking individualized homoeopathic medicine for 7 months frequency of headache declined.
BREASTFEEDING IN SPACE: CHALLENGES AND OPPORTUNITIES
Authors: S. Appannavar Vinaykumar , Tom Joseph Chrison
Published: December 2024

Breastfeeding in space presents a unique set of challenges due to microgravity, fluid dynamics, and the physiological changes that occur in both the mother and the infant. This paper explores the key factors that influence breastfeeding in space, including the behavior of milk flow, the suction mechanics, maternal health, and the developmental needs of the infant. Recommendations for further research and future applications in space exploration are discussed.
HRS INFLUENCE ON REMOTE WORK CULTURE: CHALLENGES AND OPPORTUNITIES IN A POST-PANDEMIC WORLD
Authors: Jangid Ankita
Published: December 2024

The COVID-19 pandemic fundamentally transformed work culture, accelerating the shift to remote work and introducing both challenges and opportunities for Human Resource (HR) management. This paper explores the evolving role of HR in managing remote and hybrid work environments, focusing on key areas such as employee engagement, company culture, performance management, and mental health. The paper examines the impact of remote work on traditional HR functions and highlights strategies for maintaining productivity, communication, and well-being in a virtual setting. Case studies of companies like Microsoft and Google demonstrate how businesses have successfully navigated the complexities of remote work by adopting flexible work models, enhancing digital infrastructure, and prioritizing employee well-being. Furthermore, the paper emphasizes the significance of HR in shaping inclusive and diverse remote workplaces, while also addressing the legal, technological, and cultural challenges associated with remote workforce management. By providing insights into the future of work, this study offers actionable strategies for HR leaders to foster a resilient and productive workforce in a post-pandemic world.
ANXIETY AND NICOTINE DEPENDENCE: A CASE REPORT
Authors:   PhD (Homoeopathy) Scholar, Tantia University, Sri Ganganagar, Rajasthan., Hande Santosh , Chattopadhyaya Yogita ,   Professor ,Tantia University, Sri Ganganagar, Rajasthan.
Published: December 2024

Anxiety is a common comorbid condition in Nicotine dependent individuals. A patient of 41 years presented with anxiety and Nicotine dependence. After the proper case taking a most appropriate medicine Lycopodium 1M was selected. A proper follow-up record was maintained during the whole treatment process. After a month the patient showed significant relief in anxiety. This case study emphasis the role of Homoeopathy medicines in the management of anxiety associated with Nicotine dependence.
The impact of COVID-19 on SME profitability: Insights from South Africa
Authors: Maharaj Avika , Sthembiso Msomi Thabiso
Published: December 2024

This study aims to investigate the impact of COVID-19 on SME profitability, performance, and operational efficiency. The data were gathered using a structured questionnaire targeting SMEs affiliated with the Centre for Social Entrepreneurship (CSE), Productivity SA, Johannesburg Chamber of Commerce (JCCI), and Durban Chamber of Commerce and Industry (DCCI). A purposive sampling was utilized, specifically choosing SME owners or senior management representatives. The Krejcie & Morgan formula was used to calculate a suitable sample size of 348, resulting in an 81% response rate with 282 participants successfully completing the questionnaire. The instruments’ dependability was validated by Cronbach’s alpha coefficients of 0.906 and 0.769 for the impact of COVID-19 on SMEs and profitability variables, respectively. The findings indicated that the average effect of COVID-19 on SME was 40.3546, with a standard deviation of 7.61450. The average profitability was 5.4921, with a standard deviation of 1.92297. An analysis using a one-sample t-test revealed that the influence of COVID-19 on SMEs did not show a statistically significant impact (p = 0.156). However, the effect on profitability was statistically significant (p = 0.001). These findings emphasize the diverse consequences of the pandemic on the functioning of SMEs, specifically pointing out considerable decreases in profitability. The study recommends that government agencies and financial institutions increase support for SMEs to help them recover from the profitability challenges brought on by the pandemic. Tailored financial relief programs, accessible credit facilities, and long-term recovery strategies should be implemented to cushion SMEs against future economic shocks.
Fetihname Şairlerinin Propaganda Üslubu
Authors: Tulum Muhammed Emir
Published: December 2024

Bu makalede fetihname şairlerinin propaganda üslubunun tespit edilmesi amaçlanmaktadır. Bu amaçla, bilinen örnekleri 16. yüzyıl kapsamında kalan manzum fetihnameler hakkında ön bilgi verildikten sonra fetihname şairlerinin eserlerinde uyguladıkları propagandalar incelenecektir. İncelemede, fetihname şairlerinin sıklıkla başvurduğu ve bazılarının kendine has olarak yer verdiği propagandalar maddeler hâlinde gruplandırılıp açıklanacaktır. Açıklamalar yapılırken bazı propagandaların tespiti için konuyla ilgili bilgi veren tarihî kaynaklar veya aynı konuyu işleyen başka bir manzum fetihnameyle mukayeseler de yapılacaktır. Yapılan inceleme ve açıklamaların ardından fetihname şairlerinden uyguladığı propaganda çeşitliliğiyle ya da kendine has propaganda uygulamalarıyla öne çıkanlar belirtilecektir. Fetihnamelerde bahsi geçen yerlerde yaşayan toplumların inanç değerleri bölgelere göre çeşitlilik arz ettiğinden, şairlerin uyguladıkları propagandalar da çeşitlilik göstermiştir. Bu imkân, varılan tespitlerin ilgili çalışmalar için kapsayıcı bir örnek oluşturması açısından önem arz edecektir.
I. Dünya Savaşı Sırasında Azerbaycan Türklerinin Rus Esaretinden Kaçırdığı Türk Subayları
Authors: Göktuğ Musa
Published: December 2024

Sarıkamış Harekatı’ndan sonra, esir düşen Türk asker ve subaylar Rusya içlerine ve Sibirya’ya götürülmüştür. Türk esirler, Ermeni askerlerin muhafazasında insanlık dışı bir yolculukla yaklaşık iki günde Tiflis’teki Naftlug Esir Toplama ve Aktarma Merkezi’ne taşınmıştır. Bu merkezde, yolda hayatını kaybedenler defnedilmiş, ağır hasta olanlar seçilip ölüme terkedilmiş, yaşama ihtimali olanlar Rusya’daki başka esir kamplarına nakledilmiştir. Bu nakil sırasında ikinci sırada Bakü açıklarında bulunan Nargin Adası’nda bulunan Esir Toplama ve Aktarma Merkezi gelmiştir. Buradaki koşulların Natflug’dan da ağır olmasından dolayı Türk esirler cezireye Cehennem Adası adını vermiştir. Böyle bir ortamda Azerbaycan Türkleri, hem Türk esirlere yardım etmeye hem de fırsatını bulduğunda Rus esaretindeki subayları kaçırmaya çalışmıştır. Kaçırılan subaylar, Anadolu’ya gönderilmiş, yurda döndükten sonra yeniden savaşmış, Kurtuluş Savaşı’na katılmış ve nihayet Türkiye Cumhuriyeti’nin kuruluşunda önemli görevleri yerine getirmiş ve bazı ilklere imza atmıştır. Bu çalışmada Azerbaycanlıların, Türk esirlere yönelik yardım çalışmaları ve onların kaçırılarak yurda dönmelerini sağlamaları ve en ünlü esir Türk subayların kaçırılmasıyla ülkeye döndükten sonraki faaliyetlerini içine alan tarihi süreç incelenmiş olup bu bağlamda esirlerin adaya getirilmeye başlandığı 1915 yılının ilk günlerinden, esirlerin tamamen kurtarıldığı 1918 yılının Eylül ayı ortalarına kadarki dönem ayrıntılı bir biçimde ele alınmıştır.
Qualidade ambiental de nascentes em zona rural, município de Pedra do Indaiá - MG
Authors: Fonseca Alysson Rodrigo , Nogueira Thiago Vilela , Martins Gabriela Barbosa , Cruz Mauro Cesar Cardoso , Sousa Fabrízio Furtado de , Gomides Clécio Eustaquio
Published: December 2024

Este estudo de caso teve como objetivo a identificação, georreferenciamento e análise da qualidade ambiental e microbiológica das nascentes existentes na comunidade do Camarão, zona rural do município de Pedra do Indaiá - MG. Foram avaliados impactos ambientais em 13 nascentes a partir do Índice de Impacto Ambiental em Nascentes – IIAN. A análise microbiológica daágua foi realizada através do Teste do Substrato Cromogênico (Colitest®), que mostra a presença ou ausência de Coliformes Totais e Termotolerantes. A aplicação dos testes foi realizada no período seco (julho/2022) e período chuvoso (dezembro/2022). No que se refere ao Grau de Preservação das nascentes, verificou uma classificação como "Boa" (Classe B) para 3 nascentes, "Razoável" (Classe C) e "Ruim" (Classe D) para 4 nascentes em ambas as classificações e “Péssima” (Classe E) para apenas uma nascente. Na análise microbiológica, constatou-se que todas as nascentes avaliadas apresentaram resultados positivos para presença de coliformes totais e termotolerantes (Escherichia coli). Os resultados mostraram elevado grau de degradação de praticamente todas as nascentes avaliadas.
Remodelamento espacial por mapeamento geológico sistemático do stock Itambé da Suíte Granítica Estrela do Sul, porção Meridional da Faixa Brasília
Authors: Ferraz Douglas Correa , Araujo Larissa Marques Barbosa de , Petronzio Juliana Abreu Crosara , Godoy Antonio Misson , Luna Crislayne Aparecida
Published: December 2024

O Granito Itambé constitui um dos sete stocks pertencentes à Suíte Granítica Estrela do Sul em Minas Gerais, ocorrendo nasproximidades da cidade homônima. Esse magmatismo de idade neoproterozoica ocorre intrudido na sequência metassedimentar do Grupo Araxá na porção meridional da Faixa Brasília. Este trabalho foi produto da necessidade emergencial de atualizar os mapas geológicos da área, pois através de uma análise preliminar com tratamento de imagem de satélites, mapas disponíveis e fotointerpretação foi possível identificar inconsistências relacionadas ao mapa geológico regional justificado pela sua grande escala de abrangência, apresentando dimensões, extensões e formatos distintos do observado em escala de detalhe. Como resultado foi possível estabelecer novas e reais dimensões e extensão do granito, pela utilização de técnicas de sensoriamento remoto e geoprocessamento, em conjunto do mapeamento geológico sistemático, onde foi possível o remodelamento espacial do Granito Itambé, que representa um stock granítico com cerca de 6,2 km²
A ocorrência de nitrato e sua perspectiva de depuração no cenário de um aquífero não confinado urbano com recarga variável, nordeste do Brasil.
Authors: Campos Benedita Cleide de Souza , Lucena Leandson Roberto Fernandes de , Alves Rafaela da Silva
Published: December 2024

A nitrificação das águas subterrâneas em centros urbanos normalmente decorre da infiltração de águas residuais não tratadas. Na presente pesquisa, caracterizou-se a ocorrência de NO-3 e perspectivas de depuração natural no cenário de um aquífero não confinado urbano com recarga variável. Para isso, utilizaram-se ferramentas de análises hidroquímicas e modelos numéricos, considerando a relação entre a variação da espessura do aquífero diante da variação da recarga, ocupação do solo e a estrutura da rede coletora de efluentes sanitários. Nesse contexto, quatro cenários foram inseridos nas avaliações do decréscimo das reservas de saturação e consequente impacto nas taxas de renovação teóricas do aquífero, assumindo-se a gradativa diminuição dos aportes nitrogenados das águas infiltradas. Os resultados demonstraram o aumento progressivo das concentrações de nitrato em cerca de 58% dos poços analisados no período de 2012 a 2020, com progressão das concentrações no sentindo sul da área de pesquisa. A estimativa de tempo de residência, associado com perspectivas de renovação qualitativa do manancial, variou de 6,5 a 12,9 anos, sendo este último no cenário considerado mais crítico em termos de recarga, com a supressão de 100% da contribuição proveniente de perdas pela rede de distribuição de água e infiltração de águas residuais.
Contaminação dos recursos hídricos por agrotóxicos utilizados em commodities: avaliação por modelos de simulação
Authors: Ribeiro Joseph Simões , Neves Suellen Caroline Barbosa , Lameira Lizandra Ferreira , Galúcio Milene Karoline da Silva , Silva Ygor Yuri Pereira da , Cruz Elcilene Mateus da , Lopes Ruy Bessa
Published: December 2024

Nos últimos 10 anos, a agricultura na Região Oeste do Pará, especialmente em Santarém, Belterra e Mojuí dos Campos, tem registrado um aumento significativo na produção de soja, representando 11% da produção do Estado. Esse crescimento intensivo resulta em um maior uso de pesticidas, o que provoca a contaminação dos recursos hídricos. Para avaliar os possíveis impactos ambientais, foram selecionados cinco pesticidas utilizados na soja: Roundup (Glifosato), Cyptrin (Cipermetrina), Dimilin (Teflubenzuron), Lorsban (Clorpirifos) e Lannate (Metomil). A avaliação do risco de contaminação foi feita usando modelos matemáticos como GUS, LEACH e o software SCI-GROW. Os resultados indicaram que o Metomil apresenta o maior potencial de contaminação para recursos hídricos superficiais e subterrâneos. Já o Glifosato, Cipermetrina, Teflubenzuron e Clorpirifos mostraram baixa mobilidade e menor risco de contaminação de aquíferos. Em termos de resíduos na água subterrânea, Glifosato e Clorpirifos apresentaram concentrações de 117 e 0,109 µg/L, respectivamente. O índice LEACH indicou alto risco de contaminação de águas superficiais para Glifosato e Teflubenzuron. Esses dados são essenciais para o planejamento de programas de monitoramento de recursos hídricos e avaliação de impactos ambientais, constituindo uma ferramenta eficiente e econômica.
A Review on Hepatoprotective Effect of Chrysin: Preclinical Implications and Molecular Cascades Came into Focus
Authors: Talebi Marjan , Talebi Mohsen , Farkhondeh Tahereh , Simal-Gandara Jesus , İlgün Selen , Pourbagher shahri Ali Mohammad , Samini Mohammad , Samarghandian Saeed
Published: December 2024

Chrysin, a flavone nutraceutical, possesses several beneficial pharmacological properties,
which has gained much emphasis in recent years. The biological effects of chrysin are exerted
due to impeding or activating multifarious cellular and molecular pathways. Our findings indicated
that chrysin inhibited tumor progression in various cancer cell lines by repressing the formation
of a sphere and upregulated protein expression of Src homology region 2 domain-containing
phosphatase-1 (SHP-1), alleviating phosphorylated-signal transducer and activator of transcription
3 (p-STAT3) and transaction workflow innovation standards team1 (Twist1), sustaining phosphorylation
of extracellular signal-regulated kinase 1/2 (ERK1/2) and endorsing mitogen-activated
protein kinase kinase1 (MEK1) overexpression, increasing the cytochrome c release, mitochondrial
reactive oxygen species (ROS) formation, matrix metalloproteinases (MMP) collapse, and
caspase-3 activity, modulating p53/ B-cell lymphoma-2 (Bcl-2)/caspase-9 cascade, cyclooxygenase-
2 (COX-2), nuclear factor kappa B proposition 65 (NF-kB p65) expression and also decreasing
the expression of nuclear factor erythroid 2-related factor 2 (Nrf2). Chrysin prevented cyclophosphamide,
doxorubicin, cisplatin, methotrexate, paracetamol, alcohol, carbon tetrachloride,
tert-butyl hydroperoxide (tBHP) and thioacetamide. Chrysin has protective properties against
oxidative stress, inflammation, hepatotoxicity, liver fibrosis, steatosis, and hepatocellular carcinoma.
Chrysin's most common hepatoprotective biochemical and molecular mechanisms involve the
ability to control enzyme synthesis, scavenge free radicals, boost the antioxidant response, induce
apoptosis, and modify the synthesis of proinflammatory and profibrotic cytokines.Chrysin is a
valuable nutraceutical with broad therapeutic feasibility, but to confirm its representative hepatoprotective
potential, clinical studies are advised. It would also be interesting to use cutting-edge
drug delivery techniques or include bio-enhancers.
Surgical Orthodontic Treatment of Class III Malocclusion with Unilateral Open Bite Due to Impacted Premolar with Dilacerated Root: A Case Report
Authors: Kashio Haruna , Yamaguchi Masaru , Yamazaki Astue , Minamida Yasuhito , Shimo Tsuyoshi , Mizoguchi Itaru , Iijima Masahiro
Published: December 2024

Background

Dilacerated teeth may interfere with eruption and movement, making orthodontic treatment difficult.

Case Report

This case report describes successful surgical orthodontic approaches for a 14-year-old girl with skeletal Class III malocclusion, a unilateral open bite caused by a severely dilacerated mandibular left first premolar, and severe crowding in the mandibular dentition. The patient underwent surgical subluxation of the dilacerated premolar, followed by a combination of non-extraction orthodontic therapy and orthognathic surgery.

A left lateral open bite caused by a severely dilated mandibular left first premolar was corrected through tooth traction after subluxation for root apical transection. Class I molar relationships and improved facial profiles were achieved with maxillary advancement, adjunctive counterclockwise mandibular rotation, and genioplasty.

Conclusion

This case report suggests using subluxation in severely dilacerated teeth to enable orthodontic tooth movement with high stability, thereby expanding the possibility of non-extraction treatment.
The Missing Link: Academic Motivation as a Mediator in the Relationship between Mindfulness and Critical Thinking Skills in Indonesian First-Year Undergraduates
Authors: Agoes Salim Rose Mini , Felicia Margareth Sondang , Setiamurti Astri
Published: December 2024

Background

Critical thinking is essential for university students to deal with academic demands. Preliminary research indicates that first-year undergraduate students in Indonesia have low critical thinking skills, highlighting the importance of developing these skills early to better adapt to university life.

Objective

This research examined the role of academic motivation as a mediator between mindfulness and critical thinking skills among first-year undergraduate students in Indonesia.

Methods

Data were collected through e-flyers and questionnaires distributed via social media, using convenience and snowball sampling techniques. The sample included 186 first-year students (aged 18–23, M = 18.9) from the class of 2022. Critical thinking was assessed with the Analog Test, mindfulness was measured using the 15-item Five Facet Mindfulness Questionnaire (FFMQ-15), and academic motivation was evaluated with the Indonesian Short Version of the Academic Motivation Scale. Pearson correlation and regression analyses were performed.

Results

The study found a statistically significant indirect effect of mindfulness on critical thinking, mediated by intrinsic academic motivation (β = 0.010, p = 0.027, 95% CI = 0.00065–0.023). While this mediation effect was significant, the effect size was small, suggesting that while mindfulness influenced critical thinking through intrinsic motivation, its practical significance was limited.

Conclusion

This study highlights that mindfulness predicts critical thinking primarily through intrinsic academic motivation, with no significant direct effect. The small effect size suggests that other factors may also influence this relationship. Further research is needed to identify additional mediators or contextual variables.
The Therapeutic Potential of Targeting the Pd-L1/Pd-1 Immune Checkpoint Pathway in Alzheimer's Disease
Authors: Mehrabadi Shima
Published: December 2024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
the accumulation of amyloid-β plaques, neurofibrillary tangles, and chronic neuroinflammation.
Emerging evidence suggests that the PD-L1/PD-1 immune checkpoint pathway plays a critical
role in modulating neuroinflammation, microglial function, and amyloid-β clearance in AD. This
review summarizes the current understanding of the PD-L1/PD-1 pathway in AD and discusses its
potential as a therapeutic target. Preclinical studies and clinical trials have demonstrated that targeting
the PD-L1/PD-1 axis can enhance microglial phagocytosis, promote amyloid-β clearance,
and reduce neuroinflammation. We examine the potential benefits and challenges of using existing
immunotherapy drugs, such as anti-PD-L1 and anti-PD-1 antibodies, in the context of AD.
Additionally, we explore the development of novel, more specific agents targeting the PDL1/
PD-1 pathway, as well as potential synergistic approaches with other immunomodulatory or
amyloid-β-targeting treatments. This review provides a comprehensive and up-to-date analysis of
the PD-L1/PD-1 immune checkpoint pathway's role in Alzheimer's disease, highlighting its
promising therapeutic potential for improving patient outcomes. Further research is warranted to
optimize treatment strategies and evaluate the long-term safety and efficacy of targeting this axis
in clinical settings.
Pharmacokinetic Considerations for Controlledrelease Dosage Forms
Authors: Khobragade Deepak S. , Agrawal Surendra S. , Potbhare Mrunali S.
Published: December 2024

The pharmaceutical industry has shown significant interest in controlledrelease dosage forms due to their ability to improve pharmacological therapy by
providing prolonged and regulated drug administration. The pharmacokinetic
properties of a medicine are essential in establishing its efficacy and safety in a
therapeutic setting. Controlled-release dosage forms offer significant advantages, such
as reduced dosing frequency, improved patient compliance, and fewer adverse effects.
To maximize the use of these benefits, it is critical to understand the complex interplay
between formulation design, pharmacological properties, and controlled release
systems pharmacokinetics. This chapter examines the pharmacokinetic aspects of
controlled-release formulations, providing insight into their drug-release methods,
absorption, distribution, metabolism, and excretion. The chapter also delves into the
various elements that influence the rate of drug release from controlled-release dosage
forms. These aspects include mechanisms such as diffusion, dissolution, and erosion.
This study also investigates the impact of these mechanisms on medication absorption
in the gastrointestinal tract and their influence on the drug's pharmacokinetic
characteristics. Furthermore, the chapter emphasizes the importance of employing
modeling and simulation approaches to predict the behavior of pharmaceuticals
released from controlled-release formulations. Furthermore, the chapter undertakes an
endeavor to examine the impact of pharmacokinetic parameters on the dosing schedule,
therapeutic monitoring, and methods to enhance bioavailability. The chapter also
discusses the importance of tailored drug delivery methods for specific patients, as well
as the potential of personalized medicine. Understanding the pharmacokinetic
parameters of controlled-release formulations is critical for optimizing pharmaceutical
treatment. Gained knowledge can guide the development of innovative drug delivery
methods, enhance patient outcomes, and accelerate pharmaceutical sector
advancements
Comprehensive Insights into Mucoadhesive Drug Delivery Systems
Authors: Baste Nayana S. , Shahare Shweta H. , Mundada Atish S.
Published: December 2024

Mucoadhesive drug delivery systems have gained significant attention in the
field of pharmaceutical research due to their ability to enhance drug bioavailability,
prolong residence time, and improve therapeutic outcomes. This chapter provides a
comprehensive overview of mucoadhesive drug delivery systems, highlighting their
importance in overcoming various challenges associated with conventional drug
delivery. The chapter commences by elucidating the physiological and biochemical
aspects of mucosal surfaces, emphasizing the significance of mucoadhesion in
optimizing drug absorption and distribution. It explores the diverse applications of
mucoadhesive systems across different mucosal sites, including the buccal, nasal,
ocular, vaginal, and gastrointestinal mucosa. Additionally, the mechanisms underlying
mucoadhesion, such as hydrogen bonding, electrostatic interactions, and covalent
bonding, are thoroughly examined. The chapter delves into the various classes of
mucoadhesive polymers, such as natural, synthetic, and semi-synthetic polymers,
highlighting their distinct properties, applications, and evaluations. The chapter
addresses key considerations such as biocompatibility, safety, and regulatory aspects
associated with the development of mucoadhesive formulations. In conclusion, this
chapter serves as a valuable resource for researchers, scientists, and practitioners in the
field of drug delivery, offering a comprehensive understanding of mucoadhesive drug
delivery systems and their potential to revolutionize the delivery of therapeutic agents
across mucosal membranes.
A Positive Role of Nidra in Mental Health
Authors: Neha Bishnoi  , Keshav Asiwal  , Narendra Mehta
Published: December 2024

The three primary life milestones mentioned in the ancient Ayurvedic texts are Ahara, Nidra, and Brahmacharya of these, Nidra is one that is particularly important to humans. Nidra is an essential component of daily existence. Nidra can create major medical conditions if it is not taken regularly, which can impact both physical and mental health. Many pathological illnesses known as Anidra (primary insomnia) are brought on by a lack of Nidra. It eventually develops into a chronic disorder known as secondary or tertiary insomnia. The Samhitas contain the complete study of Nidra and its classification in classical science.
Role of Millets in prevention and management of lifestyle disorders
Authors: Sneha R. Gupta  , Brijesh Mishra
Published: December 2024

To study the role of Millets in prevention and & management & lifestyle disorders. Ayurveda is recognized as the foremost life science & describes ways to prevent & manage lifestyle disorders. Ayurveda provides better solution in the forms of proper dietary management and lifestyle advisor. Millets are gluten free diet they have considerable potential in foods and beverages and can meet the growing demand of gluten free diet.
An insight into Pittaja Mutrakrichra w.s.r. to Lower Urinary Tract Infection with mechanism, risk factors & prevention
Authors: Sangeeta S. H  , Sahana M  , Waheeda Banu
Published: December 2024

In Ayurveda, diseases are named after taking into consideration of certain criteria which are very much significant. A disease named on the basis of Pravrutti of Mootra associated with difficulty in Pravrutti is Mutrakrichra i.e., passing urine with difficulty or pain. Eight types of Mutrakrichhra are described in details in Madhav Nidana - i.e., Vattaja, Pittaja, Kaphaja, Sannipataja, Shalyaja, Ashmarija, Shukraja, Purishaja Mutrakrichhra. Pittaja Mutrakrichhra was well acknowledged in Samhitas with different treatment modalities, which can be concurrent to Lower urinary tract infections on theoretical and clinical symptomatology of disease. Urinary Tract Infection (UTI) is defined as multiplication of organism in urinary tract.[1] Urinary tract infection is the inflammation of the tissues of the urinary tract.[2] Upper urinary tract infection is infection involving the kidney and lower urinary tract infection is infection involving the bladder, prostate, and urethra.[3] Hence in the present study, an attempt is made to critically analyze the disease Pittaja Mutrakrichra with its Nidana, Samprapti, Lakshana and with the disease Lower urinary tract infection. Lower urinary tract infection can be reduced by drinking plenty of fluids and completely emptying the bladder frequently. Menstrual hygiene changes sanitary pads or tampons regularly to maintain cleanliness and to prevent bacterial growth.
Efficacy of Ayurvedic treatments in Stress Management
Authors: Chakma Priyasa , Kumar Krishan
Published: December 2024

Stress is known as Sahasa in Ayurveda. Resulting Ojah Ksaya (loss of immunity), increases the body's susceptibility to various diseases. A person's lifestyle is a cumulative product and mimicries gained from his/her immediate companions, thus evolving into a well-coordinated initiation of psychological and innate control over physical and sensory activities. This can be monitored by taking adequate care of Traya Upastambha. According to Ayurveda, the amount of positive and negative stress is largely governed by three energies: Vata, Pitta, and Kapha. Depending on which one may have to deal with fear, anxiety, insomnia, isolation, etc. The ancient system of healing originating in India offers a holistic approach to managing stress by addressing the mind, body, and spirit as interconnected elements; it aims to restore balance and harmony. Through personalized diet, lifestyle recommendations, herbal remedies, and relaxation techniques, Ayurveda seeks to alleviate symptoms of stress effortlessly. This work is a compilation of Primary Ayurvedic literature and previous work to emphasize the role of Ayurvedic treatments in stress management.
Clinical Case Study on Osteoarthrosis: Integrative Treatment and Functional Improvement
Authors: Babita Jamra  , Devjinder Singh  , Rajesh Jain
Published: December 2024

Osteoarthrosis (OA) is a prevalent degenerative joint disease characterized by the progressive breakdown of articular cartilage and changes in subchondral bone, leading to pain, stiffness, and reduced joint function. Its management involves a combination of pharmacological and non-pharmacological approaches aimed at alleviating symptoms and improving quality of life.[1] Sandhivata is a term used in Ayurveda to describe a condition resembling osteoarthritis, characterized by joint pain, stiffness, and swelling. It is considered to be caused by an imbalance in the body's Doshas (humors), particularly Vata Dosha, leading to degeneration of the joints and surrounding tissues.[2] Routine full-body massage (Abhyanga) using warm, therapeutic oils aids in nourishing the tissues, improving circulation, and balancing Vata Dosha. Basti is a vital therapy for managing Vata-related conditions.
Mistakes and misunderstandings in pre-travel consultations – common areas of confusion
Authors: Bunce Alys
Published: December 2024

Travel health can be a huge topic to know a lot of things about, whilst trying to navigate many other subjects at the same time. Written by an experienced trainer in the field of travel health, this article explores some of the common misunderstandings that often come up during courses during travel health consultations in the UK.
Empowering Patients and Caregivers to Use AI and Computer Vision for Wound Monitoring: A Feasibility Study (Preprint)
Authors: Raizmam Rose , Ramírez-GarciaLuna José Luis , Newaz Tanmoy , Wang Sheila C , Berry Gregory K , Kong Ling Yaun , Mohammed Heba Tallah , Fraser Robert Douglas John
Published: December 2024

BACKGROUND

Chronic wounds affect 1-2% of the global population, and pose significant health and quality-of-life challenges for patients and caregivers. Advances in artificial intelligence (AI) and computer vision (CV) technologies present new opportunities for enhancing wound care, particularly through remote monitoring and patient engagement. A Digital Wound Care Solution (DWCS) that objective wound tracking using AI/CV was redesigned as a patient-facing mobile application to empower patients and caregivers to actively participate in wound monitoring and management.

OBJECTIVE

This study aimed to evaluate the feasibility, usability, and preliminary clinical outcomes of the Patient Connect application in enabling patients and caregivers to remotely capture and share wound data with healthcare providers.

METHODS

A feasibility study was conducted at two outpatient clinics in Canada between May 2020 and February 2021. Twenty-eight patients with chronic wounds were recruited and trained to use the Patient Connect app for wound imaging and secure data sharing with their care teams. Wound images and data were analyzed using AI/CV models integrated into the app. Clinicians reviewed the data to inform treatment decisions during follow-up visits or remotely. Key metrics included app usage frequency, patient engagement, and wound closure rates.

RESULTS

Participants captured a median of 13 wound images per wound, with images submitted every 8 days on average. The study cohort included patients with diabetic ulcers, venous ulcers, pressure injuries, and post-surgical wounds. A median wound closure rate of 80% was achieved across all patients, demonstrating the app’s clinical potential. Feedback from patients and clinicians highlighted the app’s usability, data security features, and ability to enhance remote monitoring.

CONCLUSIONS

The Patient Connect application effectively engaged patients and caregivers in chronic wound care, demonstrating feasibility and promising clinical outcomes. By enabling secure, remote wound monitoring through AI/CV technology, the app has the potential to improve patient adherence, enhance care accessibility, and optimize clinical workflows. Future studies should focus on evaluating its scalability, cost-effectiveness, and broader applicability in diverse healthcare settings.
Who are the Digital Proxies?: Prevalence and Predictors of Digital Proxy Behavior in the United States (Preprint)
Authors: Foong Pin Sym , Zakaria Camellia , Pakianathan Pavithren , Phua Andrew Ian-Hong , Koh Gerald CH
Published: December 2024

BACKGROUND

Out of necessity, dependent adults often ask proxies to help manage their digital accounts. However, data on the prevalence and predictors of digital proxy behaviour is scarce, and piecemeal.

OBJECTIVE

We aim to describe the prevalence and predictors of digital proxy behaviour among the US population, and associated demographic, behavior and care factors.

METHODS

We designed a cross-sectional online survey with a nationally representative adult cohort. 657 US residents completed the survey.

RESULTS

Our findings indicate that about 49% of the US population report having digital proxy duties, which are predicted by being male, younger, more educated, and helping with physical care. Of these, 59% handled both medical and financial duties, but each domain still has a few different predictors. Financial proxies are additionally predicted by having a higher income. In contrast, medical proxies are more
likely to come from larger families and are less likely to be from an underrepresented ethnicity in the US. The most
commonly given reasons for being a proxy are linked to low perceived usability of the interface and are less so about
the cognitive and physical disabilities of the adult delegator. These results suggest that reducing usability challenges
may reduce some of the need for proxies.
Of all the digital proxies, about 2 in 3 report having formal access to the account. Hence, informal digital proxies are
about one-third of all digital proxies, translating to about 18% of the adult caregiver population, or about 18 million
people [23]. Of these informal digital proxies, 47.5% (medical) and 55.3% (financial) report knowing the login details, and
29.8% of (medical) 35.1% (financial) report using the accounts without the account owner present. The data indicates a
higher than previously reported prevalence of proxy digital behavior, with an estimated 5.3 million people reporting
risky login and independent use of digital accounts

CONCLUSIONS

The profile of a digital proxy is often younger, male, and better educated. When helping with digital accounts, the financial and medical digital proxies were motivated by similar reasons (low perceived usability) and had similar helping patterns. In both
groups, about 1 in 10 digital proxies were accessing and operating digital accounts without the presence of the account
owner. We conclude this finding translates to an unacceptably high number of adults engaged in informal proxy tasks,
which puts vulnerable owners at risk when they lack the capacity to manage their accounts. We call for the promotion
of digital caregiver accounts with guardianship features. We further suggest that an initial intervention should educate
users from lower-income groups while mitigating the barriers to formal digital proxy accounts.

CLINICALTRIAL

none.
Reconciling Conflicting Data Curation Actions: Transparency Through Argumentation
Authors: Xia Yilin , Bowers Shawn , Li Lan , Ludäscher Bertram
Published: December 2024

We propose a new approach for modeling and reconciling conflicting data cleaning actions. Such conflicts arise naturally in collaborative data curation settings where multiple experts work independently and then aim to put their efforts together to improve and accelerate data cleaning. The key idea of our approach is to model conflicting updates as a formal argumentation framework (AF). Such argumentation frameworks can be automatically analyzed and solved by translating them to a logic program PAF whose declarative semantics yield a transparent solution with many desirable properties, e.g., uncontroversial updates are accepted, unjustified ones are rejected, and the remaining ambiguities are exposed and presented to users for further analysis. After motivating the problem, we introduce our approach and illustrate it with a detailed running example introducing both well-founded and stable semantics to help understand the AF solutions. We have begun to develop open source tools and Jupyter notebooks that demonstrate the practicality of our approach. In future work we plan to develop a toolkit for conflict resolution that can be used in conjunction with OpenRefine, a popular interactive data cleaning tool.
АНАЛИЗ ТЕНДЕНЦИЙ РАЗВИТИЯ РЫНКА УПРАВЛЕНИЯ ЦЕПЯМИ ПОСТАВОК
Authors: Левалдс Я.
Published: December 2024

Статья посвящена обзору основных тенденций развития рынка управления
цепями поставок и наиболее перспективных цифровых технологий.
Приведены положительные эффекты и возможные риски, возникающие
при внедрении рассматриваемых инноваций в системы управления
цепями поставок. Был составлен ряд рекомендаций для быстрого
и результативного внедрения цифровых технологий. Полученные выводы
могут быть использованы для повышения эффективности работы систем
управления цепями поставок в целом.
Three-Wheeler Ride Service for Elderly, Handicapped, and Women Application
Authors: Babu M. Chinna
Published: December 2024

This study presents the development and implementation of a Three-Wheeler Ride Service Application tailored to the
unique needs of elderly individuals, people with physical disabilities, and women. The application aims to provide a safe,
accessible, and user-friendly platform that addresses the mobility challenges faced by these vulnerable groups. Leveraging
modern technologies like Flutter for a responsive interface, Firebase for real-time data management, and Google Maps API for
route optimization, the app ensures seamless ride booking, live tracking, and affordability.
Key features include a user-centric interface optimized for accessibility, real-time ride safety mechanisms such as driver
verification and emergency contact integration, and specialized vehicle options for enhanced comfort and security. Additional
functionalities, such as chatbot assistance, dynamic pricing based on distance, and multi-modal payment systems, further
improve usability.
Through the integration of advanced technological solutions and a focus on inclusivity, the application bridges gaps in the
existing ride-hailing ecosystem. The platform's scalability and potential for future enhancements, such as voice-based assistance
and eco-friendly vehicle options, underscore its broader social impact, offering a transformative approach to inclusive
transportation services.
QUESTIONING ALIENATION OF HUMANITIES DISCIPLINE IN ENGLISH EDUCATION CURRICULUM
Authors: Setiawan Rahmat , Andanty Ferra Dian , Nurbani Armelia Nungki , Adhim Syarif
Published: December 2024

The English language education curriculum tends to focus on technical language issues (skills) and educational aspects. In fact, language proficiency is acquired through practice, training, and habit. Educators must have cognitive, psychological, and sociological understanding. This is the problem: English language learning tends not to involve the humanities in its curriculum. This research aims to explore the factors that make the English Education curriculum less likely to include humanities disciplines while it has crucial impact to the quality of English teaching and learning. In methodology, the type of research is qualitative. The approach in this research is case study. The data collection technique in this research is Focus Group Discussion (FGD). The type of FGD used in data collection is Single Focus Group which supports an explorative space to support the provision of data in the analysis. There are three parts to conducting FGDs: pre-activity, activity, and post-activity. The research employs the thematic analysis technique. There are three main results can be drawn implicitly by the researcher from the perspective of the English Education lecturers: Theoretical-Based Orientation, Skillset Target, and Positivistic Ideology. Firstly, the English Education curriculum processes English language learning through theories. Secondly, the English Education curriculum focuses on the English language skillset. Thirdly, the English Education curriculum aims to produce English teachers who will teach English focusing on the learning process and the learners’ internal problems in the classroom, not the learners’ external problems.
PERAN ZIS DALAM MENINGKATKAN KESEJAHTERAAN PEREMPUAN: STUDI PADA PROGRAM BUNDA MANDIRI SEJAHTERA LAZNAS YATIM MANDIRI
Authors: Tanjung Nabila Azzahra , Rohim Ade Nur
Published: December 2024

Zakat, infaq, dan sedekah (ZIS) berperan dalam mengentaskan kemiskinan. Namun, Indonesia masih dihadapkan dengan masalah kemiskinan di kalangan perempuan. Tujuan penelitian untuk mengetahui dan menganalisis implementasi penyaluran ZIS melalui program BISA serta implikasinya terhadap kesejahteraan mustahiq. Metode dalam penelitian ini statistik deskriptif dengan pendekatan studi kasus dengan menggunakan model CIBEST. Temuan penelitian menunjukan bahwa penyaluran ZIS melalui program BISA diberikan kajian-kajian, bantuan hibah dan modal usaha, dan program BISA berimplikasi terhadap peningkatan kesejahteraan dimana setengah lebih mustahiq berada pada kuadran 1.
Kata kunci : ZIS, Kesejahteraan, Mustahiq Perempuan, CIBEST