bluuebunny/crossref_metadata_2025 huggingface dataset:
O konceptualizacji pojęcia odličan w języku serbskim: analiza synonimii i budowy wewnętrznej wyrazu
Authors: Stefanović Marija
Published: December 2023

The word odličan ‘excellentʼ is used to express a positive evaluation and has a large number of synonyms, but for many of them the lexicographic sources do not provide information about the possibility of using them for expressing evaluation. Moreover, although the inner word-form of the word odličan speaks only of general standing out from other objects, the word itself is used only in a positive sense. The inner word-form semantic analysis gives the answer to the question why all the analyzed synonyms can be used for giving a positive evaluation. The article draws attention to a deep conceptual relationship between words with the meaning of dobar ‘goodʼ and odličan ‘excellentʼ, because the same basic conceptual metaphors are used in their synonyms (dobar / odličan is up / big). It was also established that words with a positive connotation are found in the inner word-form of synonyms of odličan or in their definitions, including those that indicate a relationship between a positive general assessment and a positive aesthetic assessment. The meaning of odličan differs from “ordinary” objects in such a way that it can be conceptually associated with realm of the fantastic or unreal, which in turn triggers an emotional reaction in the observer. The language reveals that objects that are evaluated positively are treated in a unique way: they are set apart from others, they function as a topic of conversation, they acquire general approval and obtain a special status in society.
Epiphysiolysis capitis femoris – Wie man sie nicht verpasst
Authors: Kocher Franziska , Ziebarth Kai
Published: December 2023

Die Epiphysiolysis capitis femoris (ECF) bezeichnet das Abrutschen des Schenkelhalses (Metaphyse) nach ventral bzw. ventro-lateral während der Femurkopf (Epiphyse) im Azetabulum lokalisiert bleibt. Ursache ist eine Verminderung der mechanischen Festigkeit der Wachstumsfuge während des pubertären Wachstumsschubes. Betroffen sind somit Jugendliche zwischen 10 und 16 Jahren, wobei Jungen ca. 1.5-mal häufiger betroffen sind. Die Inzidenz wird mit 1-10 Fälle pro 100 000 Jugendliche angegeben(1).
L’examen clinique du nouveau-né et les différences interrégionales du dépistage de la dysplasie développementale de la hanche en Suisse
Authors: Merckaert Sophie R.
Published: December 2023

Un diagnostic tardif (>3 mois de vie) de DDH est lié à une morbidité importante et nécessite souvent des prises en charge complexes et chirurgicales qui peuvent être évitées lors d’un diagnostic précoce avec mise en place d’un traitement les premières semaines de vie.
Apps y enseñanza de lengua extranjera post pandemia
Authors: Mendonça de Souza Policarpo Kadhiny , Marçal Nunes Gabriela , Faggion Bergmann Juliana Cristina
Published: December 2023

Este artículo tiene como objetivo investigar el uso de aplicaciones móviles en las clases de lenguas extranjeras en la enseñanza básica a través de una revisión sistemática y usando como base el trabajo de Policarpo y Bergmann, publicado en 2021, con datos pre pandémicos. Como resultados, tras aplicar las mismas estrategias de búsqueda, lo que se encontró fueron 488 publicaciones, pero, al aplicar los criterios de inclusión y exclusión, se ha quedado apenas 20 trabajos que tenían como objetivo el uso de aplicaciones en las clases de lenguas extranjeras. Entre estos resultados, se notó un crecimiento en el número de publicaciones en Latinoamérica, justo porque gran parte de los trabajos son de países como Colombia, Ecuador y Brasil. Así que, más allá de los datos, este trabajo también se dedica a investigar esta creciente en el uso de apps de lenguas extranjeras en la enseñanza básica en los países latinoamericanos.
Reworking the recipe: Adding experimentation and reflection to exercise physiology laboratories
Authors: MacInnis Martin , Din Cari
Published: December 2023

Our research project aims to replace recipes with authentic science in exercise physiology laboratories. By providing students with more autonomy and encouraging them to reflect on their activities, we anticipate that our reformed laboratories will help students develop the skills of a scientist.
Marketing Potential of Homemade Food: a New Entrepreneurial Endeavour
Authors: Muneerali Thottoli Mohammed , Suhail Al Mazroui Tif Said , Amur Al Hoqani Duaa Suleiman , Al-Alawi Maather Mohammed
Published: December 2023

This study aims to examine the marketability of homemade food and to understand the need for an entrepreneurial venture start-up in Oman. In addition, it explores barriers to buying or selling homemade food. The research is based on a qualitative study using purposive sampling techniques by an indepth interview with 83 aspirant buyers and sellers of homemade food. The study’s findings confirm that the marketability of homemade food can be achieved by developing a unique application for trading these products, that will help to avoid barriers to buying or selling. Most respondents preferred eating homemade food rather than restaurant or commercially prepared food. These research findings provide entrepreneurs with some insight in terms of new venture start-ups for marketing homemade food in niche markets. This research comprises a specific approach to the marketability of homemade food and suggests a unique mobile app for trading homemade food. The data was gathered in Nizwa, Oman, however it could be broadened to encompass more geographic regions, particularly urban areas. The research results, achieved using qualitative methodologies, contribute significantly to the body of existing literature. It enhances value in analysing probable barriers among aspirant buyers and sellers of homemade food.
MICROWAVE MIXER ON RECTANGULAR WAVEGUIDES PARTIALLY FILLED BY DIELECTRIC
Authors: Pochernyaev Vitaly , Syvkova Nataliia , Mahomedova Mariia
Published: December 2023

The article investigates and calculates the characteristics of microwave mixers on rectangular waveguides partially filled by dielectric. Presents diagrams of promising combined microwave radio engineering systems - two options for constructing mobile digital troposcatter-radiorelay stations, the antenna-feeder paths of which are implemented on rectangular waveguides partially filled by dielectric. At research of microwave mixers, suppression and the use of the mirror frequency are taken into account. The analysis of researches of microwave mixers is carried out. The design of a balanced-type microwave mixer based on rectangular waveguides partially filled by dielectric is developed. The mixer is used to convertion the microwave signal into an intermediate frequency signal. The signal conversion of the mixers takes place on the non-linear active resistance of the semiconductor diode. In article, an open nonlinear structure is used as such a diode. The following main parameters of microwave mixers are investigated: conversion losses, noise factor, operating frequency band, signal suppression at the mirror frequency. The conversion losses are determined for various mirror channel suppression conditions. Phase methods of mirror frequency suppression are considered, which are most suitable for the waveguide implementation of microwave mixers. A scheme of a microwave mixer of a balance type with a phase method for suppressing the mirror frequency is presented. The article notes that for significant suppression of the mirror frequency of more than 30 dB, a double frequency conversion mixer is used. A diagram of a slotted bridge based on rectangular waveguides partially filled by dielectric is presented. The dependences of the input impedance of the mixer, the impedance of the mixer at the intermediate frequency, the impedance of the mixer at the mirror frequency by the power of the local heterodyne are plotted.
ADVERTISING BIDDING OPTIMIZATION BY TARGETING BASED ON SELF-LEARNING DATABASE
Authors: Kvуetnyy Roman , Bunyak Yuriy , Sofina Olga , Kaduk Oleksandr , Mamyrbayev Orken , Baklaiev Vladyslav , Yeraliyeva Bakhyt
Published: December 2023

The method of targeting advertising on Internet sites based on a structured self-learning database is considered. The database accumulates data on previously accepted requests to display ads from a closed auction, data on participation in the auction and the results of displaying ads – the presence of a click and product installation. The base is structured by streams with features – site, place, price. Each such structural stream has statistical properties that are much simpler compared to the general ad impression stream, which makes it possible to predict the effectiveness of advertising. The selection of bidding requests only promising in terms of the result allows to reduce the cost of displaying advertising.
AUTOMATIC ADJUSTMENT OF REACTIVE POWER BY FACTS DEVICES UNDER CONDITIONS OF VOLTAGE INSTABILITY IN THE ELECTRIC NETWORK
Authors: Burbelo Mykhailo , Babenko Oleksii , Loboda Yurii , Lebed Denys , Kolesnytskyj Oleg K. , Rakhmetullina Saule J. , Mussabekov Murat
Published: December 2023

This article describes the problem of automatic regulation of reactive power using electronic devices FACTS (Flexible AC Transmission Systems): static synchronous compensator (STATCOM) and unified power flow controller (UPFC). With the help of a complex writing form, the following are determined: voltages at the installation nodes of the FACTS device and loads, currents of loads, power sources and electronic compensators in case of voltage instability at the load node of the electrical network. Voltages and currents are determined using the node-voltage method. The task of STATCOM is partial or full compensation of reactive power. During the reduction of the voltage at the load node, the reactive power generated by the power source decreases. The STATCOM should partially or fully compensate for the reactive power imbalance as quickly as possible. However, at the same time, it is not possible to fully compensate for the voltage reduction. A series-parallel or parallel-series UPFC can be used to solve this problem. As a result of using the UPFC, it is possible to automatically raise the voltage level to acceptable values with the help of the UPFC series compensator. The analysis shows that the parallel-serial UPFC is characterized by the stability of operation. In the case of using a series-parallel UPFC, there are restrictions on the ability to adjust the imaginary voltage component of the series compensator, since the angle of the voltage vector changes, which causes a failure in the operation of the regulator of the parallel compensator UPFC.
PENERAPAN PELAYANAN PRIMA PADA DONGENG ANAK REMAJA KELILING (DARLING) DINAS PERPUSTAKAAN DAN KEARSIPAN PROVINSI JAWA TIMUR
Authors: Firly Erysa Faldilal Nuraini  , Oktarizka Reviandani
Published: December 2023

This research aims to determine the application of excellent service in the Fairy Tales of Traveling Teenagers (Darling) at the East Java Province Library and Archives Service. DARLING (Fairy Tales for Traveling Teenagers) is innovative and provides excellent service for the East Java Province Library and Archives Service. The DARLING program promotes reading and introduces children and teenagers to moving fairy cars. Qualitative descriptive methods were used in this research. The data collection technique uses data triangulation, combining interviews, literature study and documentation. The research results show that DARLING has successfully implemented the A6 principle of excellent service.
EKSPLORASI KEWENANGAN PEMERINTAH DESA KULO KABUPATEN SIDRAP DI BIDANG PERTANIAN: PELUANG DAN TANTANGAN
Authors: Nur Ahmad Fauzan  , Syafa'at Anugrah Pradana  , Sunandar
Published: December 2023

Penelitian ini menganalisis mengenai wewenang pemerintah Desa dibidang pertanian yang ditinjau dari perspektif Undang-Undang Nomor 19 Tahun 2013 tentang Perlindungan dan Pemberdayaan Petani. Metode yang digunakan dalam penelitian ini yaitu pendekatan kualitatif dengan subjek pemerintah Desa dan masyarakat petani. Sedangkan teknik pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukan bahwa pelaksanaan kewenangan Pemerintah Desa Kulo dalam pemberdayaan Petani Desa Kulo Kecamatan Kulo Kabupaten Sidrap telah berjalan dengan baik. Terdapat beberapa pelaksanaan kewenangan yang bersifat substantif dalam pemberdayaan Petani oleh Pemerintah Desa seperti penyaluran informasi, pelatihan dan pendidikan, penyediaan fasilitas, dan penguatan kelembagaan Kelompok Tani, pengawasan dan pelaksanaan distribusi bantuan pupuk, serta pembimbingan Petani. Pemerintah Desa Kulo juga melakukan kegiatan pelatihan pembuatan pupuk kompos dan penggunaan alat pertanian modern seperti handtracktor, robot panen padi dengan melakukan sinergitas dengan Dinas Pertanian.
Analisis Kebutuhan Penerapan PAIKEM Di Sekolah Minggu Pada Jemaat Genesis Wilayah Tobelo Kota
Authors: Itje Tomi , Taliawo Harun , Saliding Apriani , May Oscar Jeferson Scheitzer , Ice Demianus
Published: December 2023

Penelitian ini bertujuan untuk mendeskripsikan kebutuhan penerapan metode pembelajaran aktif, inovatif, kreatif, efektif, dan menyenangkan (PAIKEM) dalam pembelajaran di Sekolah Minggu (Sekolah Minggu ) pada Gereja Masehi Injili di Halmahera (GMIH) Jemaat Genesis Wilayah Tobelo Kota. Metode yang digunakan adalah kualitatif dengan observasi sebagai teknik pengambilan data. Obyek amatan adalah metode penyampaian firman Tuhan pada saat ibadah Sekolah Minggu. Hasil penelitian menunjukkan bahwa metode PAIKEM sangat perlu diterapkan dalam pembelajaran di Sekolah Minggu pada Gereja Masehi Injili di Halmahera (GMIH) Jemaat Genesis Wilayah Tobelo Kota karena metode yang digunakan adalah bercerita atau ceramah sehingga mengakibatkan anak-anak Sekolah Minggu cepat bosan dan tidak fokus saat pembelajaran tentang firman Tuhan.
Tinjauan Etis Kristiani tentang Kekudusan Seksual Terhadap Praktik Sunat Sifon di Suku Atoni Meto, Nusa Tenggara Timur
Authors: Panjaitan Firman , Boymau Darius Arnoldus
Published: December 2023

Sunat Sifon adalah sebuah tradisi dari suku Atoni Meto. Praktik sunat Sifon sangat khas, karena setelah seorang laki-laki menjalani sunat, ia harus melakukan hubungan seksual dengan perempuan lain yang bukan istri atau pasangan tetap, dengan tujuan untuk menghilangkan panas, kotoran atau penyakit. Persetubuhan itu dilakukan untuk “mendinginkan” luka sunat. Penelitian ini bertujuan menggali filosofi tradisi sunat Sifon dan menunjaunya dari pandangan etika Kristen. Penelitian ini menggunakan metode kualitatif, khususnya melalui pendekatan studi pustaka dan wawancara langsung dengan beberapa pelaku sunat SIfon. Hasil penelitian menunjukkan bahwa sunat Sifon bertentangan dengan etika Kristen karena mengeksploitasi perempuan secara seksual dan menodai kekudusan perkawinan.
Hambatan Anak Mengikuti Pembelajaran Di Sekolah Minggu Pada Gereja Kristen Indonesia Klasis Sentani
Authors: Banga Berthin Samuati , Roragabar Yeni Irawati , Sarwuna Adrianus
Published: December 2023

Penelitian ini bertujuan untuk mengkaji peran orang tua dan gereja dalam menumbuhkan motivasi anak mengikuti pembelajaran di Sekolah Minggu di Gereja Kristen Indonesia Klasis Sentani. Metode penelitian yang digunakan adalah gabungan metode kuantitatif dan kualitiatif. Prosedur dalam megumpulkan data yaitu melalui teknik angket, wawancara, dan observasi. Partisipan penelitian adalah orangtua dan guru Sekolah Minggu, serta 30 anak Sekolah Minggu. Hasil penelitian menunjukkan bahwa anak-anak sebenarnya memiliki motivasi yang kuat untuk mengikuti pembelajaran di Sekolah Minggu namun mereka menghadapi sejumlah hambatan. Hambatan pertama adalah kurangnya dukungan orang tua, baik dalam hal-hal yang bersifat teknis maupun dalam pemberian motivasi. Hambatan kedua adalah belum optimalnya upaya gereja memfasilitasi pembelajaran di Sekolah Minggu, mulai dari belum diterapkannya kurikulum, minimnya perangkat pembelajaran yang tersedia, hingga kurangnya ketrampilan guru dalam menggunakan metode pembelajaran yang kreatif. Selain itu, orang tua dan guru belum melakukan komunikasi yang intensif terkait dengan pembelajaran di Sekolah Minggu. Karena itu, agar pembelajaran Sekolah Minggu di GKI Klasis Sentani dapat berjalan dengan baik sehingga memotivasi anak-anak semakin giat mengikuti pembelajaran di Sekolah Minggu, maka orang tua dan gereja perlu meningkatkan peran masing-masing dengan baik.
Persepsi Perempuan Di Jemaat Namaasi Meselesek Tentang Perceraian Akibat Kekerasan Dalam Rumah Tangga
Authors: Mea Friska , Mosooli Ermin Alperiana , Pohan Juan Erwin
Published: December 2023

Gereja hingga saat ini masih melarang perceraian dilakukan warganya. Namun faktanya angka perceraian terus naik. Salah satu penyebab perceraian di Indonesia adalah kekerasan dalam rumah tangga (KDRT) di mana korbannya sebagian besar adalah perempuan. Penelitian ini bertujuan mengetahui persepsi perempuan Kristen di salah satu gereja lokal di Sulawesi Tengah tentang perceraian akibat KDRT. Metode penelitian yang digunakan adalah kuantatif dengan pendekatan survey. Data diambil dengan angket, diukur menggunakan skala Likert dengan pilihan Sangat Setuju, Setuju, Tidak Setuju, dan Sangat Tidak Setuju. Data dianalisa dengan analisa deskriptif menggunakan aplikasi SPSS. Dari 30 responden yang berpartisipasi, hasilnya ditemukan bahwa responden memberikan tanggapan rata-rata Setuju untuk pernyataan: 1) tidak ada gunanya mempertahankan pernikahan yang penuh dengan kekerasan; 2) perceraian adalah salah satu jalan keluar untuk mengakhiri KDRT; 3) perceraian merupakan keberanian korban untuk mengakhiri perilaku KDRT; 4) larangan gereja untuk bercerai merupakan salah satu hambatan bagi korban untuk melepaskan diri dari belenggu KDRT. Dari hasil ini dapat disimpulkan bahwa apabila dalam menghadapi masalah KDRT gereja hanya bersikeras melarang warganya bercerai tanpa memberikan solusi yang konkrit bagi korban KDRT maka larangan perceraian tidak akan efektif untuk meredam laju kenaikan angka perceraian di kalangan umat Kristen.
Quantum Vacuum: Fundamentals and Frontiers
Authors: Hernández Pedro Javier Villanueva
Published: December 2023

This article examines the quantum mechanics of the vacuum, highlighting
its evolution from a concept of absolute “nothingness” in classical
physics to a space of effervescent quantum activity. The Schrödinger
equation and its relevance to understanding the dynamic nature of the
vacuum are discussed, along with the Heisenberg Uncertainty Principle
and its implications for quantum fluctuations in the vacuum. The
zero-point energy, the cosmological constant and its relationship with
the expansion of the universe, and the Casimir effect are also
addressed. The article concludes with a review of emerging practical
applications in fields such as quantum computing, space propulsion, and
quantum cryptography, and reflects on the promising future of vacuum
physics.
Choosing the Lesser Evil: The Holy Office, the Jews and Voltaire. Censorship Notes on La difesa de’ libri santi e della religione giudaica (Venice, 1770)
Authors: Benfatto Miriam
Published: December 2023

It is possible to uncover certain aspects of the Catholic Church’s attitude towards Jews, the Enlightenment and philosophical-cultural productions through case studies of Catholic control and censorship in the late eighteenth century. In this vein, an analysis of the censorship notes produced by the Roman Holy Office on the content of the book La difesa de’ libri santi e della religione giudaica, published in Venice in 1770, can be particularly useful. The original documents, currently held at the Archives for the Congregation of the Doctrine of the Faith (formerly the Holy Office, Rome), shed light on the methods and approaches the Catholic Church adopted to control the circulation of new ideas in a century characterised by profound intellectual, cultural and political change.
Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain
Authors: Antón Jordi , Moreno Ruzafa Estefania , Lopez Corbeto Mireia , Bou Rosa , Sánchez Manubens Judith , Carriquí Arenas Sonia , Calzada Hernández Joan , Bittermann Violetta , Estepa Guillén Carolina , Mosquera Angarita Juan , Rodríguez Díez Lucía , Iglesias Estíbaliz , Marti Masanet Miguel , Lopez Montesinos Berta , González Fernández Maria Isabel , de Lossada Alfonso , Peral Carmen , Valderrama Mónica , Llevat Noelia , Montoro Álvarez María , Calvo Penadés Immaculada
Published: December 2023

Background: Juvenile idiopathic arthritis (JIA) is the most frequent chronic rheumatic disease in children. If inflammation is not adequately treated, joint damage, long-term disability, and active disease during adulthood can occur. Identifying and implementing early and adequate therapy are critical for improving clinical outcomes. The burden of JIA on affected children, their families, and the healthcare system in Spain has not been adequately assessed. The greatest contribution to direct costs is medication, but other expenses contribute to the consumption of resources, negatively impacting healthcare cost and the economic conditions of affected families. Objective: To assess the direct healthcare, indirect resource utilization, and associated cost of moderate-to-severe JIA in children in routine clinical practice in Spain. Methods: Children were enrolled in this 24-month observational, multicentric, cross-sectional, retrospective study (N = 107) if they had been treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs), had participated in a previous study (ITACA), and continued to be followed up at pediatric rheumatology units at 3 tertiary Spanish hospitals. Direct costs included medication, specialist and primary care visits, hospitalizations, emergency visits or consultations, surgeries, physiotherapy, and tests. Indirect costs included hospital travel expenses and loss of caregiver working hours. Unitary costs were obtained from official sources (€, 2020). Results: Overall, children had inactive disease/low disease activity according to JADAS-71 score and very low functional disability as measured by Childhood Health Assessment Questionnaire score. Up to 94.4% of children received treatment, mainly with bDMARDs as monotherapy (84.5%). Among anti-TNFα treatments, adalimumab (47.4%) and etanercept (40.2%) were used in similar proportions. Annual mean (SD) total JIA cost was €7516.40 (€5627.30). Average cost of pharmacological treatment was €3021.80 (€3956.20), mainly due to biologic therapy €2789.00 (€3399.80). Direct annual cost (excluding treatments) was €3654.60 (€3899.00). Indirect JIA cost per family was €747.20 (€1452.80). Conclusion: JIA causes significant costs to the Spanish healthcare system and affected families. Public costs are partly due to the high cost of biologic treatments, which nevertheless remain an effective long-term treatment, maintaining inactive disease/low disease activity state; a very low functional disability score; and a good quality of life.
Probiotics as a means of strengthening commensal skin microbiota in the treatment of infected soft tissue wounds
Authors: Tulupov A.A. , Beschastnov V.V. , Tyumenkov Yu.O. , Kovalishena O.V. , Shirokova I.Yu. , Belova I.V. , Tochilina A.G. , Solovieva I.V.
Published: December 2023

Probiotics can promote wound healing by stimulating the production of immune cells, activation of reparative regeneration processes as well as show antagonism against pathogenic microflora. The data presented in this review of the literature indicate that the local use of probiotics to enhance the microbiota of the skin in the fight against pathogens of wound infection is a scientifically sound direction demonstrating clinically significant positive results. The results of laboratory and experimental studies can form the basis for further development and development of methods for the clinical use of probiotics in the treatment of patients with infected wounds.
Pharmacokinetics of biapenem in critically ill patients
Authors: Zyryanov Sergey K. , Butranova O.I. , Kazanova A.M.
Published: December 2023

Objective.
To assess biapenem PK parameters in critically ill adult patients and define the optimal dosing regimens based on TDM data.

Materials and Methods.
An open, prospective, uncontrolled, single-center study based on City Clinical Hospital No. 24, Moscow (October 2022 – April 2023), included patients over 18 years of age with a diagnosed severe bacterial infection received 600 mg of biapenem as 3-hour intravenous infusion every 12 hours in the intensive care unit. Blood sampling during the TDM included taking blood samples immediately before the next infusion of biapenem to determine the residual concentration (Ctrough) and immediately after the end of the infusion to determine the peak concentration (Cmax). Concentrations were assessed using HPLC-UV method.

Results.
Total population – 20 patients (75% ≥ 60 years; 65% women). The main indications for biapenem were lower respiratory tract infections (80%) and intra-abdominal infections (35%). Bacterial culture tests revealed growth in 45% (Klebsiella pneumoniae – 87,5%). During the TDM 40 samples were obtained (Cmax from 15 to 42 mg/l (mean – 28.7 mg/l), Ctrough from 0.5 to 15 mg/l (mean – 3.56 mg/l)). The Kel value ranged from 0.09 to 0.48 1/h (mean – 0.29 1/h); Vd – from 7.41 to 42.49 l (mean – 16.33 l); T1/2 – from 1.4 to 7.5 hours (mean 2.94 hours). Probability of target attainment (%fT ≥ MIC) was assessed depending on MIC. For MIC of 2 mg/l, 40%fT ≥ MIC was achieved in 100%, 60%fT ≥ MIC – in 100%; 80%fT ≥ MIC – in 75%. For MIC – 8 mg/l, 40%fT ≥ MIC was achieved in 90%, 60%fT ≥ MIC – in 45%, 80%fT ≥ MIC – in 15%.

Conclusions.
The dosing regimen 600 mg of biapenem as 3-hour intravenous infusion every 12 hours demonstrated achievement of effective antibiotic concentrations in blood plasma of critically ill patients exceeding the MIC (2 mg/l). To manage patients infected with resistant strains (MIC of 4–16 mg/l) it is necessary to perform additional studies assessing PK parameters of biapenem at higher doses.
Cefodizime: pharmacological characteristics and potential for clinical use in lower respiratory tract infections
Authors: ​Rachina S.А. , Alkhlavov A.A. , Gasanova D.R. , Golub A.V.
Published: December 2023

Cefodizime is a third–generation cephalosporin for parenteral use that has become available for the first time in the Russia. This paper reviews the use of this antibiotic in clinical practice based on the current data on antimicrobial resistance in pathogens causing lower respiratory tract infections and the results of completed clinical studies of its efficacy and safety.
Rapid syndromic approach to diagnosis of bacteremia – results of the first experience
Authors: Popov Dmitriy A. , Vostrikova T.Yu.
Published: December 2023

Objective.
To describe results of the first experience of using a syndromic approach to the diagnosis of bacteremia using multiplex panels for real-time polymerase chain reaction (real-time PCR).

Materials and Methods.
The prospective study included 10 consecutive positive blood cultures obtained from 10 patients in the intensive care unit after cardiac surgery. Hemocultures were carried out in BacT/ ALERT FA Plus vials using a BacT/ALERT 3D 120 incubator (bioMérieux, France). After short subcultivation on blood agar (4-6 hours), monocultures were identified using a MALDI-ToF mass spectrometer Vitek MS (bioMérieux, France) with sensitivity to antimicrobial drugs determined on a Vitek-2 compact analyzer (bioMérieux, France). The production of carbapenemases was detected phenotypically using a modified carbapenem inactivation method (mCIM test); the molecular type of enzymes was determined using immunochromatographic tests (NG-Test CARBA 5, NG Biotech, France). In parallel with the described process of identifying microorganisms and determining their sensitivity to antibiotics, positive blood cultures were analyzed using a FilmArray 2.0 analyzer and multiplex real-time PCR panels BioFire FilmArray BCID2 (bioMérieux, France).

Results.
Using MALDI-ToF mass spectrometry, the following microorganisms were identified in the studied blood cultures: K. pneumoniae (n = 5), E. faecalis (n = 2), A. baumannii (n = 1), Raoultella ornithinolytica (n = 1) and S. aureus (n = 1). 4⁄5 (80%) of K. pneumoniae isolates were resistant to carbapenems; another 1 isolate produced an ESBL and remained sensitive to carbapenems. All carbapenem-resistant K. pneumoniae gave a positive result of the mCIM test, while the immunochromatographic method detected the production of carbapenemases of the molecular types NDM (n = 1), KPC (n = 1), as well as combinations of KPC + OXA-48 (n = 1) and NDM + OXA-48 (n = 1). All E. faecalis were sensitive to ampicillin, isolates of A. baumannii and R. ornithinolytica remained sensitive to carbapenems, S. aureus was sensitive to cefoxitin. Using the real-time PCR, 9⁄10 (90%) pathogens were identified to species level in 10 positive blood cultures. In the remaining 1 case (R. ornithinolytica, not included in the list of detected species), the microorganism was assigned to the order Enterobacterales. The data obtained by the traditional method completely coincided with the results of real-time PCR analysis, while the time to obtain results was statistically significantly shorter compared to traditional microbiological method (22 hours versus 49 hours, p < 0.001). In 7⁄10 (70%) cases, based on the results of real-time PCR analysis, a decision was made to change the tactics of antibiotic therapy.

Conclusions.
Real-time PCR analysis using BCID2 panels is an effective and reliable tool for the etiological diagnosis of bacteremia.
LITERATURE REVIEW OF BULLYING ASSESSMENT : A CRITICAL REVIEW OF THE INVENTORY OF BULLYING SCALE IN SCHOOLS
Authors: Ratna Wulandari  , Desi Yunita Putri
Published: December 2023

Bullying is still a serious problem in Indonesia. The impact of bullying on its victims is very real. Meanwhile, on average, educators, especially guidance counselors, education staff, and parents only become aware of bullying after it has happened. If early detection efforts are made, the case can be anticipated earlier. This is because there are no measurement instruments that can assist the counseling teacher in detecting cases of bullying that occur easily and on a large scale. So it is necessary to digitize the bullying scale instrument. Instruments in the form of self-reports are the most commonly used method in collecting data to assess bullying phenomena. This method has several advantages. The Olweus Bully/Victim Questionnaire (OBVQ) is one of the most widely used instruments to measure the prevalence of bullying worldwide. This questionnaire provides students with a clear definition of bullying that includes three important characteristics: (1) intent to harm others; (2) repetitive behavior; and (3) the power imbalance between victims and perpetrators. The OBVQ can be adapted into a bullying scale inventory that is appropriate to the conditions and culture in Indonesia so that it can be used to detect bullying phenomena that occur in Indonesian youth, especially at school.
REGIONAL GOVERNMENT'S STRATEGY TO HANDLE THE IMPACT OF FREE ASSOCIATION IN THE EX-GEMPOL PORONG LOCALIZATION
Authors: Efendi Yuli Kartika , Adiliya Putri
Published: December 2023

The objective of this study is to describe the strategy of Kaliploso village government in dealing with the impact of promiscuity in Gempol Porong localization area, Cluring District, Banyuwangi Regency. This research used a qualitative descriptive approach. Data collection techniques were conducted by interview, observation and documentation methods. The data analysis used is Miles and Huberman method. The analysis unit in this study is village government and youth. The results showed that Kaliploso village government's strategy by innovating through the village work program which held various activities to mobilize the  youth to participate actively and productively in positive activities went quite well and significantly. The Kaliploso village government has also collaborated with several related parties as an effort to monitor and anticipate the activities carried out by teenagers. The village work programs implemented are 1) KHC (Kaliploso Horty Carnival), 2) Kaliploso Rijig, 3) The  workshops of the drugs dangerous , 4) livestock assistance, and 5) Al-Qur'an Garden Agrotourism. In dealing with the impact of promiscuity in Gempol Porong localization area, this village program is also expected to change the image of the village become better.
Índice de resiliência dos sistemas de abastecimento de água frente a Cenários de Seca
Authors: Luciana Jorge Nayara , Malheiros Tadeu Fabrício , Francieli de Almeida Amanda , Dedini Felício Julia
Published: December 2023

Os eventos climáticos extremos poderão gerar diversos impactos negativos, inclusive nos sistemas de abastecimento de água, sendo importante que o conceito de resiliência esteja institucionalizado nos processos de gestão do setor, visando melhorar seu planejamento. Portanto, o objetivo deste artigo é apresentar um modelo de avaliação de resiliência para os sistemas de abastecimento de água frente a eventos de seca e aplicar em uma operadora de abastecimento de água pertencente às Bacias PCJ. Para isso, a metodologia consistiu em uma revisão da literatura para identificar as dimensões e indicadores para elaboração do modelo e posteriormente sua aplicação e cálculo da resiliência da operadora. Como resultado, o modelo elaborado propõe 4 dimensões: “Ameaça Climática”; “Desenvoltura”; “Robustez” e “Recuperação”, sendo que a resiliência alcançada pela operadora em estudo foi de 78,7%. Sendo assim, conclui-se que o modelo elaborado nesta pesquisa é uma ferramenta de tomada de decisão que possibilita a priorização de ações pela operadora, pois além do índice de resiliência, permite visualizar quais dimensões precisam de mais atenção.
Palavras-chave: Resiliência. Seca. Abastecimento de Água.
EXPLORING INVESTOR'S DECISIONS IN ESTIMATING THE EFFECT OF EARNING PERSISTENCE, FINANCIAL LEVERAGE, FOREIGN OWNERSHIP ON COMPANY REPUTATION AND VALUE IN NIGERIA
Authors: Dr. Ebe Emmanuel Chukwuma  , Dr. Nwankwo Peter Emeka  , Caroline Obiageli Nnamani
Published: December 2023

This study evaluates the effect of exploring investors decisions in estimating the effect of earning persistence, financial leverage, foreign ownership on company reputation and value We used multiple regression models on secondary data obtained from the annual and accounts of sampled consumer firms listed in Nigeria Stock Exchange spanning for ten (10) year from 2012-2021. The findings revealed that earnings before interest and tax (EBIT) and market capitalization (MCAP) are positively correlated though not significant at P- value. On the other hand, it can be deduced that the sensitivity of market capitalization to the control variable asset tangibility (at) is statistically positive and insignificant at P-value = 0.502 also but that has a positive and significant effect on financial leverage. It was documented that there exist perfect relationships between asset tangibility, financial leverage and natural logarithm of total assets connoting presence of colinearity. It is easily adjusted using colinearity diagnostics given the non-existence of both lagged values and dummy variables. The implication of the finding revealed that earnings before interest and tax (EBIT) and market capitalization (MCAP) are positive and can be used in predicting the movement of predictors variables regarding regressand; financial leverage, earnings before interest and tax and foreign ownership of consumer firms in Nigeria. The study hereby recommends that: consumer firms should not rely on debt financing but as well lay hand on the other means of increasing its working capital, thus; internal finance, general reserve etc. Above all, there will be collaborate between the firm and foreign partnership to improve financial performance, they should also focus on increasing wealth of the firm ensuring that the firms investors have their return on investment as when due.. Finally, firm management should adjust its administrative expense in order to increase profit for the year to encourage prospective investors.
KEY WORDS: Return on investment, earnings and growth, foreign investors and profitability
Metateatralne finały Ibsena
Authors: Partyga Ewa
Published: December 2023

W artykule podjęta została próba interpretacji porównawczej finałów trzech sztuk Ibsena Rosmersholmu (1886), Heddy Gabler (1890) i Budowniczego Solnessa (1892). Metateatralne techniki wykorzystane przez autora w tych trzech scenach finałowych służą problematyzacji sytuacji nascenicznych widzów i widowni teatralnej oraz różnych strategii odbiorczych. Śmierć bohaterów dramatycznych zostaje ukazana w metateatralnej ramie skonstruowanej w każdym tekście trochę inaczej. Metateatralne zabiegi dopełniają się, by uwypuklić siłę percepcyjnych schematów, zademonstrować sposób ich działania, podsunąć możliwości ich podważenia. Ibsen nie stara się jednak uprzywilejować żadnej strategii odbioru, zachęcając w ten sposób widza, by wziął osobistą odpowiedzialność za sens tego, co widzi. We wszystkich omawianych sztukach scena teatru w teatrze staje się także miejscem egzystencjalnego powtórzenia. Dlatego do analizy i interpretacji wprowadzona została Kierkegaardowska koncepcja powtórzenia, która pozwala spojrzeć na teatr jako na miejsce potęgowania świadomości. Ibsenowskie motywy metateatralne wzmacniają tę funkcję teatru, a jednocześnie pomagają  zrozumieć, że zarówno sens teatralnego dzieła czy wydarzenia, jak i proces jego odbioru są uwikłane w Kierkegaardowską dialektykę paradoksu.
Technology driven livestock farming for food security and sustainability
Authors: Pampori Zahoor , Sheikh Aasif
Published: December 2023

Advent of industrialization increased the human population significantly and it expanded very rapidly from nineteen sixties. Introduction of mechanization, chemical fertilization and genetic selection in agriculture increased the food production, reduced pestilence and thus improved life expectancy. However, in doing so the natural resources were over utilized, degraded and polluted. The greenhouse gas emissions from anthropogenic activities increased several folds that resulted into global warming, the consequences of which are being observed in the form of floods, draughts, cloud bursts, melting of glaciers, rising of sea level and loss of species. The soil fertility & water table is decreasing, resistance to pesticides, drugs, antibiotics is increasing and immergence & reemergence of diseases are common. Since the world population by 2050 is anticipated to touch 9 billion that means an increase of 30%. Obviously, the demand for food to feed such a huge population would require 70% increase in the food. With limited resources, depleted soil, polluted atmosphere, disturbed ecosystems and exhausted natural resources, the challenges for food security have amplified. Urbanization, improved incomes and dietary changes will increase the demand for food of animal origin in coming years.  Globally animal products provide 67% of the protein and the requirement for meat and milk by 2050 is expected to increase by 73% and 58% respectively. Therefore, to ensure food and nutritional security in coming years, livestock production has to be augmented efficiently, smartly and sustainably. As such, precision, smart livestock farming is inevitable that must integrate all the techniques, skills, knowledge and innovations to produce safe, sufficient, affordable, accessible and sustainable animal food with minimum environmental impacts. With the advancement in robotics, biosensors, artificial intelligence, internet of things and information technology, the farming practices should now be technology driven, smart, need based, automated, productive and integrated.
Assessment of carbon loss related to Soil loss in the tropical watershed of Maharashtra, India
Authors: Shelar Rahul , Nandgude Sachin B. , Atre Atul A. , Gorantiwar Sunil D. , Durgude Anil G. , Patil Mahesh R.
Published: December 2023

Soil carbon pools have a significant impact on the global carbon cycle and soil erosion caused by natural or human activities is one of the main drivers of changes in soil carbon sequestration. The present study aimed to estimate the carbon loss associated with soil loss in the watershed using remote sensing and GIS techniques. The study was carried out at the Central MPKV Campus Watershed, Rahuri, located in the rain shadow region of the Maharashtra state, India. The soil loss from the watershed was estimated using USLE model. The soil loss and carbon loss from the watershed were estimated before the implementation of conservation measures and after the implementation of conservation measures. It was found that the average annual soil loss from the watershed before and after conservation measures was 18.68 t/ha/yr and 9.41 t/ha/yr, respectively. Carbon loss was determined by soil loss rate, organic carbon content and the carbon enrichment ratio. The carbon loss from the watershed before and after conservation measures was 348.71 kgC/ha/yr and 205.52 kgC/ha/yr. The findings revealed that soil and carbon erosion was very severe on steep slopes without conservation measures and with limited vegetation cover. It was found that by reducing the carbon loss associated with soil loss, soil conservation measures not only aid in the conservation of natural resources but also serve as a climate change mitigation measure.
Detection of fumonisin among different strains of Fusarium spp. associated with bakanae disease of rice (Oryza sativa L.) using molecular markers
Authors: Singh Vikram , Ashwani Kumar  , Promil Kapoor  , Mahaveer Singh Bochalya
Published: December 2023

Bakanae disease caused by Fusarium fujikuroi of basmati rice causes huge economic losses varying with varieties produced, with a frequency of 3.0-95.4%. The Fusarium spp. associated with bakanae disease produce fumonisins, a group of structurally similar sphingosine analogue mycotoxins, among which Fumonisin B1 is the most prevalent and active (FB1). The worst harm to both people and animal wellbeing is created by fumonisins, which infect feed and food sources. IARC, a global organization dedicated to cancer research, classified FB1 as a potential causing human cancer (Group 2B). Altogether 26 strains of Fusarium spp. from bakanae infected  samples of various popular basmati rice varieties collected from Hisar, Jind, Fatehabad, Bhiwani, Sirsa, Panipat, Sonipat, Karnal, Yamunanagar, Kaithal and Kurukshetra (eleven) districts of Haryana state. Two specific primers namely VERTF and polyketide synthase (PKS) (involved in fumonisin biosynthesis) FUM (rp 32 and rp 33) were utilized in this investigation to differentiation between fumonisin-producing and non-producing strains employing PCR technique. Twenty-two strains were significant for the VERTF primer and showed the capacity to generate fumonisin, while four isolates evaluated negative for both primers. The FUM specific primer displayed positive respose only in nine strains and rest were negative. The present study provides a rapid and specific method that helped in accurate differentiation between fumonisin-producing and non-producing strains.
Molecular characterization of selected fungal and bacterial endophytes in acid lime
Authors: Gangupalli Razia Sulthana Begum , B. G. Rajulu , T. Rajasekharam , Ch. Ruth , B. Tanuja Priya
Published: December 2023

Endophytes are the microorganisms that are present in living tissue of various plant parts (roots, fruits, stem, seed, leaf etc,). Endophytic microorganisms are good source of antibiotics. Endophytic antagonists were isolated from the roots of healthy acid lime plants collected from major acid lime growing areas of Andhra Pradesh. A total of 8 fungal and 10 bacterial endophytic antagonists were isolated. The antagonists were further subjected to preliminary screening, out of which only 6 endophytic fungal antagonists (EFA 1-6) and 8 endophytic bacterial antagonists (EBA 1-8) isolates showed good inhibitory effect on radial growth of Fusarium solani causing dry root rot in acid lime in vitro. Among them the one of the best fungal and bacterial antagonists that were found to be extremely efficient against Fusarium solani in dual culture assay were selected for further molecular identification. The BLAST results revealed that one of the fungal isolate had shown 100% similarity with Aspergillus fumigatus and one of the bacterial isolate had shown 95.56% similarity with Pseudomonas aeruginosa.
Synthesis and application of biochar in conjunction with various amendments to improve salt-affected soil and crop productivity
Authors: Patle Tirunima , Sharma Sanjay K. , Trivedi S.K. , Tomar Avinash Singh
Published: December 2023

Soil salinity is an important abiotic constraint that affects soil quality and crop productivity and has a direct impact on crop yields. Ensuring the sustainable use of saline soils while maintaining environmental integrity is of utmost importance. To achieve this, it is essential to explore and implement methods that can enhance productivity without causing harm to the ecosystem. In the current study, the effect of biochar, Simultaneous inoculation of biomes (Trichoderma harzanium and Pseudomonas fluorescence) and gypsum on soil properties and growth parameters of chickpea was investigated. Of all treatments, the combination of 75 percent GR + biochar@20t/ha and biome @2kg/ha had the greatest effect on lowering pH (9.32 to 7.61), EC (3.65 to 1.6 dSm-1) and SAR (24.22 to 5.9 Cmolc (+) kg-1). As a result, there was a notable improvement in the length of chickpea shoots and roots as well as the overall production of dry matter.
A randomized clinical trial of Shaman chikitsa versus Shaman chikitsa with vamana in vitiligo (Shwitra)
Authors: Damor Girish Kumar , Raut Krupali , Kulkarni Satyajit
Published: December 2023

Vitiligo is a chronic skin disorder due to melanocyte destruction in the epidermis. It is a social stigma. Therefore, it affects the patient psychologically as well. Various therapies have been evaluated in the management of vitiligo. Vamana is a helpful panchakarma to treat skin diseases, but it has still not been studied. To study the efficacy of Vamana, we randomly selected 30 patients with vitiligo and divided them into two groups of 15 patients in each group. For Group A, Vamana was administered, and oral Swayambhu Guggul was administered at 500 mg/day with cow urine and Savarnakar Lepa for local application. This treatment was given for six weeks. In Group -B, the same treatment was given without Vamana. The Vitiligo Area Severity Index (VASI) and overall assessment were used to assess the results. Group A decreased the score from 59.67 to 27.20 ± 18.28, and Group B decreased the score from 42.6 to 36.2 ± 7.58. The P value was statistically significant in Group A and nonsignificant in Group B. In the overall assessment, Group A showed statistically significant results. We concluded that Vamana with Shaman Chikitsa is more efficacious than Shaman Chikitsa alone, but more studies are required to ascertain whether vitiligo can be reversed completely by the combined treatment of Vamana and Shaman Chikitsa.