bluuebunny/crossref_metadata_2025 huggingface dataset:
PERLINDUNGAN HUKUM TERHADAP KONSUMEN PADA TRANSAKSI ONLINE PERJALANAN WISATA
Authors: Artanto Tri , Bhakti Rizki Tri Anugrah
Published: May 2023

Indonesia merupakan salah satu tujuan wisata dunia, dan perkembangan teknologi informasi yang berpengaruh salah satunya adalah terkait transaksi online dalam melakukan perencanaan dan membeli paket perjalanan wisata. Transaksi online adalah suatu transaksi yang dilakukan oleh produsen atau penjual dan pembeli melalui alat elektronik secara online seperti website, email dan social media tanpa ada perjumpaan langsung antara pembeli dan penjual. Pelaku pariwisata dan konsumen dalam melakukan jual beli melalui transaksi online ada keuntungan dan kerugian baik dari pihak pelaku pariwisata maupun pihak pembeli atau konsumen. Penelitian ini bertujuan mengetahui perlindungan hukum terhadap konsumen dalam melakukan transaksi online perjalanan wisata. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian hukum normatif, dan sifat penelitian ini adalah deskriptif analitis. Hasil penelitian menunjukkan bahwa secara hukum transaksi online yang dilakukan oleh konsumen yang biasanya dilakukan dengan menggunakan biro perjalanan, maka biro perjalanan bertanggungjawab penuh terhadap semua konsumen, terutama terhadap jaminan keselamatan, jaminan kualitas, jaminan kenyamanan perjalanan, serta kemudahan akses pembayaran mengunakan transaksi elektronik terhadap jasa yang diberikan. Dengan potensi risiko yang luas, Biro Perjalanan Wisata harus mengedepankan aspek-aspek hukum yang akan memproteksi kelangsungan usaha. Disamping itu transaksi elektronik dengan konsumen dan pihak-pihak lain yang berhubungan dengan operasional wajib dilandasi oleh perjanjian-perjanjian yang mengikat kedua belah pihak.
KECELAKAAN LALU LINTAS TERHADAP KEALPAAN YANG MENGAKIBATKAN MATINYA SESEORANG
Authors: Siagian Anna Adriani , Malau Parningotan , Heryanto Medi , Bhakti Rizki Tri Anugrah
Published: May 2023

Tujuan dalam penelitian ini adalah untuk mengetahui bagaimana kecelakaan lalu lintas yang sering terjadi diakibatkan karena kealpaan, sehingga mengakibatkan mati atau hilangnya nyawa seseorang. Dalam hal ini Pasal 44 ayat 1 KUHP yang berbunyi: “Barangsiapa melakukan perbuatan yang tidak dapat dipertanggung jawabkan kepadanya karena jiwanya cacat dalam pertumbuhan atau terganggu karena cacat, tidak dipidana. Metode yang digunakan dalam KUHP dan juga UU No.22 Tahun 2009 tentang lalu lintas dan angkutan umum yang mengatur mengenai kecelakaan lalu lintas yang terjadi khususnya seperti kass yang terjadi sudah pantas untuk terdakwa. Penelitian ini adalah penelitian normatif dengan studi kepustakaan. Data-data yang digunakan adalah data sekunder yang terbagi atas tiga bahan hukum yaitu bahan hukum primer, bahan hukum sekunder dan tersier. Data-data yang diperoleh dianalisis cara kualitatif dan menarik sebuah kesimpulan.
Implementation of Online Think Pairs Share (OTPS) Model to Improve Student Learning Outcome
Authors: Fitriyanti Nurwulan , Zevika Mona , Zakwandi Rizki
Published: May 2023

This study was an online classroom action research (PTK) due to the COVID-19 pandemic. This study aimed to improve learning outcomes in calculus classes for physics engineering students using think pairs share. The online think pairs share (OTPS) learning model was optimized using the Learning Management System (LMS) platform in two learning cycles. The research sample was 46 students in the study program of physics engineering. The data were obtained from the pre-test-post-test scores, group discussions, and individual presentations. The results showed that the pre-test and post-test scores in cycle I were 37.16 and 68.41, while in cycle II, 41.20 and 68.65, respectively. In addition, the daily student score from the group discussion and individual presentation was 60.68 for the cycle I and 60.15 for cycle II. Furthermore, inferential analysis using the Kolmogorov-Smirnov test proves that tcount > ttable. Hence, the result indicated that implementing the OTPS learning model optimized using LMS could improve the student learning outcomes in calculus.
Argentine Chaotic Term Length Series in an American Historical Context
Authors: Felice Carmelo José , Ruiz Gabriel Alfredo
Published: May 2023

The political stability of a government depends on the norms that come from a state of rights. Several metrics have been proposed to measure political stability, but they must be applied carefully to individual countries or to compare countries. In the related literature the cultural factors are not directly considered and are limited to quantifying their practical effects. Concepts such as contempt for authority have not been directly quantified. This study proposes indicators that account for the cultural concept of contempt for authority and permit a rapid quantitative and visual analysis of the political stability of a country or province throughout its history. A specific historical analysis for the Republic of Argentina between the 16th and 21st centuries was realized. The results found indicate 1) the permanence of socially toxic behavior patterns in Argentina and other Latin American countries, 2) that inherited cultural causes could explain the high political instability in Argentina over the last 500 years and 3) a succession of singles term length by ruler during decades could be used to stabilize a country.
PoM & ToM - Harnessing the Power of Mind in Theory of Mind by shaping beneficial mental states in Preschoolers and the ICT’s role
Authors: Drigas Athanasios , Bamicha Victoria
Published: May 2023

The mental processes that constitute the Power of Mind use thinking as their primary tool. Thought creates emotions which in turn cause corresponding behavior. Consequently, thoughts act as motivators that propel the individual to action. Therefore, the quality of each piece of thinking is fundamental to its evolution. The child gradually develops the ability to read the mental states of others, relying both on the beliefs he has created about himself according to his thoughts and perceptions and on subconscious actions that affect him unconsciously. The current literature review studies the importance of the Power of Mind (PoM) in the human factor and its relationship with Theory of Mind (ToM) in preschool age. The conclusions of the research reflect the importance of the Power of the Mind in the formation of thoughts, beliefs, and emotions in young children, presenting several methods of utilizing it in the educational process.
Padronização e exatidão de réguas endodônticas milimetradas
Authors: Macêdo Danilo Teixeira , Sousa Itallo Matheus Macário Alencar de , Lima Luciana Reinaldo , Falcão Carlos Alberto Monteiro , Feitosa Giselle Torres
Published: May 2023

Objetivo: Avaliar e comparar a padronização e a exatidão de réguas endodônticas milimetradas entre três diferentes marcas disponíveis no mercado, comparando seus comprimentos, com a medida padrão do paquímetro. Metodologia: Trata-se de um estudo laboratorial quantitativo onde trinta réguas foram selecionadas e incluídas em 3 grupos de 10, de acordo com a marca comercial: 1. Prisma; 2. MK Life e 3. Maquira. Em cada régua foi aferida a medida de 15, 20, 25 e 30 mm, por meio de um paquímetro eletrônico digital. Quanto à padronização, utilizou-se o teste t de student (p < 0,05), já em relação à exatidão, os resultados foram expressos através da média e erro médio de cada grupo, comparando assim os resultados entre as unidades de cada grupo. Resultados: Após a análise estatística, as réguas produzidas pela marca Prisma e MK Life mostraram-se padronizadas por não apresentarem diferenças significantes (p > 0,05), já em relação à exatidão apresentaram menores erros médios absolutos, por se aproximarem dos comprimentos nominais, entretanto a régua da marca Maquira foi a menos padronizada e exata, segundo os mesmos testes analisados. Conclusão: As réguas endodônticas da marca Prisma e MK Life, mostraram-se padronizadas e exatas. Contudo, as réguas endodônticas da marca Maquira não apresentaram padronização e exatidão.
The effect of service quality on students’ satisfaction in the University Health Centre at Universiti Utara Malaysia
Authors: Eriad Pricilla Putri , Low Kah Choon , Zulfiani Dini
Published: May 2023

Service quality is an issue that organizations must address particularly service-oriented organizations. This quality will indicate whether the organization achieved the requisite level of quality based on the expectations of the organization and the students. This study is aimed to determining that focus on the effect of service quality on students’ satisfaction in the University Health Centre at Universiti Utara Malaysia. The methodology of this research, design used was a quantitative approach and assessed the five dimensions of service quality (independent variables), which were tangible, reliability, responsiveness, assurance, and empathy. This study employed a cluster sampling technique. The questionnaire was distributed to students of Universiti Utara Malaysia who stayed in Sime Darby Student Residential Hall and 117 students responded to the questionnaire. The SPSS version 29 was used to analyse the data. The findings from the analysis revealed that tangible, reliability, responsiveness, assurance, and empathy were found to record significant effects towards students’ satisfaction. In addition, the responsiveness, assurance, and empathy variables were highly significant in determining students’ satisfaction. Practical and theoretical implications for comprehending the characteristics of the effect of tangible, reliability, responsiveness, assurance, and empathy would make academic and service providers be more concern about students’ satisfaction to improve service quality in the University Health Centre.
Rancang Bangun Sistem Pendukung Keputusan Untuk Mencari Kecocokan Siswa Dalam Memilih Jurusan di Kampus Berbasis Web Dengan Metode (Simple Additive Weighting) Saw
Authors: Maziyyah Zarra , Besuki Bambang Minto , Habibi Anang
Published: May 2023

AbstractWrong major is a term that is often heard among students. This terms appears along with the many students who admit that the college major they are choose is not accordance with themselves. Many factors cause students choose wrong major, including students who donâ€™t know about their interest and talents, and minimum direction from experienced ones. The impact of thisÂ  phenomena is make students lose enthusiasm and are not enthusiastic about studying. This study examines how to determine college majors using the Simple Additive Weighting (SAW) method. This study7 requires some data including the value of high school subjects from semesters 1 to 5, and also multiple intelligence test scores. The data is then processed using the SAW method so as to produce 3 recommendations for suitable majors. The research method is quantitative because the data entered is in the form of numerical data. The results of testing inform that students who are suitable for their majors are 92,5%.Â AbstraksiSalah jurusan adalah istilah yang sering didengar di kalangan mahasiswa. Istilah ini muncul seiring banyaknya mahasiswa yang mengaku kalau jurusan kuliah yang dijalaninya tidak sesuai dengan dirinya. Banyak faktor yang mengakibatkan mahasiswa salah jurusan, diantaranya yaitu mahasiswa kurang mengetahui tentang minat dan bakatnya, serta kurang adanya pengarahan dari yang berpengalaman. Dampak dari salah jurusan diantaranya membuat mahasiswa hilang semangat dan tidak bergairah untuk menjalani perkuliahan. Penelitian ini mengkaji cara menentukan jurusan kuliah menggunakan metode Simple Additive Weighting (SAW). Penelitian ini membutuhkan beberapa data diantaranya adalah nilai mata pelajaran SMA dari semester 1 sampai 5, dan juga nilai tes kecerdasan majemuk. Data tersebut kemudian diolah menggunakan metode SAW sehingga menghasilkan 3 rekomendasi penjurusan yang cocok. Metode penelitian yang digunakan yaitu metode penelitian kuantitatif karena di dalamnya data yang dimasukkan berupa data numerik. Hasil pengujian menunjukkan bahwa mahasiswa yang cocok jurusannya sebesar 92,5%.
Trophoscapes of predatory fish reveal biogeographic structuring of spatial dietary overlap and inform fisheries bycatch patterns
Authors: Wells BK , Santora JA , Bizzarro JJ , Billings A , Brodeur RD , Daly EA , Field JC , Richerson KE , Thorson JT
Published: May 2023

Trophic interactions are proximate drivers of ecosystem function, including predator-prey dynamics, and their spatio-temporal variability may reflect ecosystem shifts and changes in trophic transfer. We investigated biogeographic structuring of trophic interactions by analyzing multi-decadal time series of diet for Pacific hake Merluccius productus and Chinook salmon Oncorhynchus tshawytscha from a large marine ecosystem. We compared our predictions for spatio-temporal variability of hake and salmon trophoscapes (i.e. spatially explicit predictions of trophic relationships) to inform ecosystem dynamics and fishery bycatch patterns. We have 3 inter-related findings pertaining to the spatial coherence of the trophoscapes and the potential consequences to juvenile and sub-adult (i.e. after the first year at sea but prior to maturation) salmon when sharing foraging areas with Pacific hake. First, the spatial scale of Pacific hake diet represents coastwide variability, and the spatial variability of Chinook salmon diets differs across regions and demonstrates a broad diet. Second, the expectation for increased diet and spatial overlap of Pacific hake and Chinook salmon during low productivity periods (e.g. periods with low krill biomass, suboptimal upwelling) can inform fishery management challenges. In this regard, we explore the role of shared foraging habitats on increased predation, and consequentially reduced recruitment, by Pacific hake on juvenile salmon during sub-optimal upwelling conditions. Third, we show that above-average bycatch of sub-adult Chinook salmon was associated with later spring transition, potentially as a result of both Pacific hake and salmon sharing foraging areas and prey species on the shelf and shelf break.
SOSIALISASI PENGGUNAAN APLIKASI INDEKS PENYAKIT PASIEN RAWAT JALAN DENGAN MENGGUNAKAN MICROSOFT ACCESS DI RUMAH SAKIT KOTA PADANG
Authors: Oktamianiza
Published: May 2023

Kartu Penyakit Pasien adalah suatu daftar yang berisikan data pasien, diantaranya jenis penyakit dan keadaan sakit berdasarkan suatu sistem klasifikasi atau kode penomoran sebagai sarana komunikasi. Berdasarkan survey yang telah dilakukan di beberapa rumah sakit di Kota Padang, penerapan indeks penyakit pasien masih secara manual sehingga kurang efektifitas petugas dalam pembuatan pelaporan statistik rumah sakit. Dengan masalah yang ada peneliti akan membuat sebuah pengembangan sistem dengan merancang sebuah aplikasi indeks penyakit pasien berbasis elektronik. Metode penelitian bersifat Research and Development (R&D) dengan merancang kartu indeks utama pasien, dengan pengembangan pembuatan aplikasi dengan menggunakan Unified Modeling Language (UML) yaitu dengan Use Case, Activity Diagram, Entity Realitionship Diagram (ERD) dan Data Flow Diagram (DFD). Aplikasi indeks penyakit pasien telah berjalan dengan baik, dilihat dari efesiensi, dan tanggapan petugas pada saat uji coba aplikasi. Petugas memberikan tanggapan yang baik terhadap aplikasi berkaitan dengan jalannya aplikasi, karena prosesnya tidak dilakukan secara manual, kami berharap agar aplikasi indeks penyakit pasien ini dapat digunakan secara berkelanjutan dalam pelayanan kesehatan.
Pendampingan Pemanfaatan Inovasi Teknologi Layanan Puskesmas 7G (Gesit, Gak Antri, Gak Ribet, Gratis, Go Cashless, Gak Lemot, Gemati)
Authors: Dwi Astuti Nina , Irmawati  , Muh. Rifqy Aufa Daffa  , Noor Taufik Hidayat
Published: May 2023

Citra Puskesmas sampai saat ini masih dianggap kurang baik dalam memberikan pelayanan kepada masyarakat. Pemerintah Kota Semarang membuat program inovasi pemanfaatan teknologi yang diberi nama Layanan Puskesmas 7G (Gesit, Gak Antri, Gak Ribet, Gratis, Go Cashless, Gak Lemot, Gemati). Program ini telah mulai diluncurkan sejak September 2019 namun masih banyak masyarakat yang belum mengetahui layanan Puskesmas 7G. Kegiatan pengabdian masyarakat berupa pendampingan pemanfaatan layanan Puskesmas 7G ditujukan kepada 30 kader kesehatan di Kelurahan Jabungan, Kecamatan Banyumanik, Kota Semarang. Hasil pre dan post test menunjukkan adanya perbedaan yang signifikan antara pengetahuan sebelum dan sesudah kegiatan pendampingan. Setelah dilakukan kegiatan pendampingan, kader dibekali dengan berbagai media promosi yang akan disebarluaskan melalui media WhatsApp grup RT. Diharapkan, setelah masyarakat mengetahui berbagai layanan inovasi ini, mereka mau memanfaatkan layanan-layanan tersebut dan merasakan manfaatnya. Citra positif Puskesmas diharapkan dapat meningkat.
Establishing tagasaste from seed in Waikato hill country
Authors: Tozer Katherine , Douglas Grant , Dawbin Caitlyn , Greenfield Rose , Cameron Catherine
Published: May 2023

Tagasaste (tree lucerne) can be difficult to establish from seed due to its hard seed coat and high levels of seedling mortality. Three experiments were performed. Experiment 1: Effect of gibberellic acid, potassium nitrate, seed nicking + soaking in warm water (38oC for 24 hours), soaking seeds in boiling water and a coldwater control on germination. The highest germination percentage occurred from the warm and boiling water treatments. Experiment 2: Effect of slug bait, rhizobia and phosphorus fertiliser on establishment of tagasaste seed which had been hand sown into a herbicide-treated pasture. Of the 1600 hand-sown seeds, emergence was negligible, and no treatments varied significantly from the untreated control. Greater pasture suppression is required for successful establishment. Experiment 3: Examined removal of 20%, 40%, 60% or 80% of the height of a seedling on tagasaste branching. Branch number was similar for all treatments 83 days aftertrimming the main stem. Removing 20% or 40% of the seedling height produced three-fold greater edible dry matter than when 80% of the seedling height was removed (P<0.001). Although pruning treatments did not affect branch number, a less severe pruning regime resulted in the regrowth of the greatest amount of edible dry matter.
Doravirine and Rilpivirine Intra Cellular Accumulation in the Clinical Setting
Authors: M Ferrara , G Trevisan , L Marinaro , G Accardo , S Fantino , F Alladio , E Drappero , M Tettoni , E De Vivo , A Ianniello , A De Nicolò , A D’Avolio , A Calcagno , S Bonora
Published: May 2023

Background: Doravirine (DOR) and Rilpivirine (RPV) are the NNRTIs currently most used in the clinical setting, in dual and triple drug regimens (2DR and 3DR). Intracellular (IC) Pharmacokinetics (PK) of these drugs has not been fully elucidated. Our aim was to compare plasma PK and IC accumulation in real-life experienced patients (pts). Methods: Pts on DOR- and RPV-including Antiretroviral (ARV) regimen were considered. DOR and RPV plasma and IC (PBMCs) concentrations were measured at 12 (37%) (T12) and 24 ± 4 hours (63%) (T24) after last drug intake by means of UHPLC-MSMS validated methods. Results: 90 pts (65% on 3DR and 35% on 2DR) were included: 52% on DOR- and 48% on RPV-containing ARV. RPV IC/plasma ratio was significantly higher than DOR IC/plasma ratio: 6.034 (4.878-7.186) vs. 1.479 (1.256-1.702) (p=0.001) independently from timing T12 (p=0.003) and T24 (p<0.001). RPV in 3DR resulted to have higher plasma and IC accumulation compared to 2DR. Linear and significative correlations between DOR and RPV plasma and IC concentrations were found (+0.749, p<0.001 and +0.733, p<0.001). No significative correlation between overall DOR and RPV PK and creatinine, BMI or age or difference by gender was found. Conclusion: RPV proved to accumulate in PBMCs at a higher degree as compared to DOR: RPV and DOR IC levels were 498% and 50% higher than in plasma. RPV showed an IC PBMC/plasma ratio 3-fold higher than DOR. Potential explanation could rely on the higher lipophilicity of RPV. Clinical significance of these data needs to be investigated in further studies.
The Analyzing Materiality Level Consideration Based on Auditorâ€™s Professionalism, Professional Ethics and Auditorâ€™s Experience
Authors: Puryati Dwi , Prananda Nabila , Nur Fatimah Novelia Ellena
Published: May 2023

AbstractThe objective of this study was to analyze the impact of an auditor's expertise, professional ethics, and experience on the level of materiality at a Public Accounting Firm in Bandung. This study methodology incorporated descriptive analysis and verification techniques. The research population consists of all auditors employed by a Bandung public accounting firm. The research sample was determined using a purposive sampling technique and the result was 41 auditors from 12 Public Accountant Firms in Bandung. Data collection techniques were carried out through questionnaires. The data analysis was carried out using regression analysis, determination coefficient, and hypothesis test. Before analyzing the data, instrument tests and classical assumption tests were carried out. The findings revealed a favorable and statistically significant effect of the auditor's professionalism, professional ethics, and experience on the amount of materiality considered by Bandung Public Accounting Firms. Consideration of the level of materiality was influenced by the auditorâ€™s professionalism, professional ethics, and experience by 52.1%, while the other 47.9% was determined by other factors that were not researched in this study.Keywords:Â Auditor; Experience; Materiality; Professionalism; Professional ethics.Â AbstrakPenelitian ini dilakukan di Kantor Akuntan Publik di Kota Bandung dengan tujuan menganalisis pengaruh profesionalisme auditor, etika profesi dan pengalaman auditor terhadap pertimbangan tingkat materialitas. Analisis deskriptif dan verifikatif digunakan sebagai pendekatan dalam penelitian ini. Populasi penelitian adalah semua auditor yang bekerja pada Kantor Akuntan Publik di Kota Bandung. Sampel penelitian berjumlah 41 auditor dari 12 Kantor Akuntan Publik di Kota Bandung. Teknik penentuan sampel yang digunakan adalah purposive sampling. Pengumpulan data dilakukan melalui kuesioner.Â Â MetodeÂ analisisÂ datayangÂ digunakanÂ adalahÂ analisis regresi berganda, koefesien determinasi dan uji hipotesis. Sebelum data dianalisis dilakukan uji instrument dan uji asumsi klasik.Â Â Hasil penelitian menunjukkan pengaruh yang positif dan signifikan dari variabel profesionalisme auditor, etika profesi, dan pengalaman auditor terhadap pertimbangan tingkat materialitas. Profesionalisme auditor, etika profesi dan pengalaman auditor mempengaruhi pertimbangan tingkat materialitas sebesar 52.1%, sedangkan pengaruh dari faktor lain yang tidak diteiliti dalam penelitian ini sebesar 47.9%.Kata kunci:Â Auditor; Etika profesi; Materialitas; Pengalaman; Profesionalisme.
Bioinformation Search for Biologically Active Substances in Coniferous Plants of the Picea Genus Distribution in the Urals
Authors: Chertov N. , Boronnikova S.
Published: May 2023

In coniferous plants of the Picea Genus, common in the Urals, using a bioinformatic approach, 12 biologically active substances were selected, in which potential biological activity was evaluated. The analyzed biologically active substances belong to terpenes and terpenoids, they are divided into 2 groups, which, along with others, have antibacterial and anti-inflammatory activities. BAS with antibacterial activity were identified as promising: canfen, α-pinene, β-myrcene, trans-caryophyllene, borneol, manool. Bioinformatics analysis is only the first step in the study of biologically active substances in coniferous plants.
Gentle Blood Sampling From Tortoises (Testudines) to Detect Blood Parasites
Authors: Gurbanova T.
Published: May 2023

Blood can be drawn from the jugular, brachial, femoral, ventral and dorsal coccygeal veins, occipital venous sinus, and heart from most species of tortoises and aquatic turtles. An alternative method for obtaining high-quality blood samples from tortoises of the genus Testudofor the detection of blood parasites by blood extraction using a medicinal leech (Hirudo medicinalis) has been proposed. One or two leeches were placed on each individual, depending on the body weight of the turtle. The time spent by leeches on blood sucking took from 20 minutes to 1 hour (average 35 minutes). After the pumped leeches fell off, they were immediately placed in sterile double-dish, where they contacted with a cotton swab moistened with ethyl alcohol in order to cause regurgitation of the sucked blood. In a comparative study of microscopic specimens prepared from blood samples of the spur-thighed tortoise obtained by two methods of exsanguination: cardiopuncture and medical leeches, no qualitative differences were found. In all specimens, blood cells and intraerythrocytic stages of blood parasites were equally suitable for identification. This method of exsanguination is also effective, as well as traditional methods of blood sampling from turtles, but in contrast to them, it is simple to perform, more humane and safer for these animals.
Geoecological Hazards Under the Conditions of Climate Changes in the Subtropical Zone of the Caucasus
Authors: Dzaganiia L. , Dzaganiia E.
Published: May 2023

The subtropical zone of the Caucasus is one of the most attractive areas for life, which contributes to population growth, and, as a result, additional development of previously undeveloped natural areas. Under the conditions of climate change and increasing anthropogenic pressures, the stability of ecosystems is reduced, and the likelihood of hazardous processes is increasing. The objectives of the work are: a review of the scientific literature on the problems of the development of dangerous geoecological processes in the subtropical zone of the Caucasus under the conditions of climate change, the study of achievements in the field of research, a comparison of various concepts, the definition of the theoretical basis and methods of research, justification of the relevance of the topic, the development of hypotheses and assumptions that will be verified in future research.
Atomic Emission Analysis in the AC Arc of Heavy Metals in Deposits of Petrochemical Industries
Authors: Nasibullina L. , Akhsanova O. , Sagdeeva G.
Published: May 2023

Environmental pollution with heavy metals is one of the most pressing problems, due to a wide range of negative effects of heavy metals, including a detrimental effect on vegetation, soil, as well as degradation of the ecosystem as a whole. Sources of heavy metals pollution are mining and ferrous metallurgy enterprises, petrochemical plants, machine-building plants. Determination of the content and concentration of heavy metals in the current environmental situation is more than relevant for assessing the quality of the environment. Currently, there are two main groups of analytical methods for the determination of heavy metals: electrochemical and spectrometric methods. Atomic emission analysis in an alternating current arc is a powerful method of qualitative analysis of heavy metals in deposits of petrochemical industries, thanks to the ability to simultaneously determine directly in powder up to 70 macro- and microelements with detection limits up to millionths. As part of this work, patent studies were conducted to determine the technical level and identify scientific and technical developments.
PENGARUH DEEP BACK MASSAGE TERHADAP NYERI PERSALINAN KALA 1 FASE AKTIF DI PUSKESMAS CISOLOK KABUPATEN SUKABUMI TAHUN 2021
Authors: Elawanti Elawanti , Aulya Yenny , Widowati Retno
Published: May 2023

Persalinan tanpa nyeri hanya dialami sedikit ibu hamil. Nyeri bersifat subyektif artinya antara individu satu dan lainya berbeda dalam menyikapi nyeri. Nyeri persalinan dapat menimbulkan stres yang menyebabkan pelepasan hormon yang berlebihan seperti katekolamin dan steroid. Hormon ini dapat mengakibatkan penurunan kontraksi uterus, penurunan sirkulasi uteroplasenta, pengurangan aliran darah dan oksigen ke uterus, serta timbulnya iskemia uterus yang membuat impuls nyeri bertambah banyak. Tujun mengetahui pengaruh terapi deep back massage terhadap nyeri persalinan pada ibu multipara kala 1 fase aktif. Penelitian menggunakan desain quasi eksperimen dengan one group pre test-pos test. Sampel dalam penelitian berjumlah 20 responden ibu bersalin multipara pembukaan 4-7 yang diberi terapi deep back massage. Teknik pengambilan sampel dengan purposive sampling. Instrument penelitian berupa kuesioner Numerical Rating Scale (NRS) sebelum dan sesudah diberikan terapi simplesia ginkgo folium selama 20 menit dengan frekuensi 30-40 gosokan permenit, sebanyak 5 kali. Data diolah menggunakan hingga uji paired t-test. Hasil penelitian menunjukan ada pengaruh terapi deep back massage pada ibu bersalin multipara kala 1 fase aktif terhadap penurunan intensitas nyeri didapatkan hasil rata-rata mean sebelum 7,40 dan sesudah 5,00 dengan selisih mean 2,40. Uji paired t-test dengan nilai  t = 9,798 dan nilai P-value 0,000 < 0,05 menunjukkan terapi deep back massage menurunkan rasa nyeri nilai secara signifikan.
Pengaruh Terapi Murottal Al-Qur'an Terhadap Penurunan Intensitas Nyeri Dan Tingkat Kecemasan Pada Ibu Bersalin Multipara Kala I Fase Aktif
Authors: Yuliana Fitri , Aulya Yenny , Widowati Retno
Published: May 2023

Nyeri persalinan merupakan suatu kondisi fisiologis yang mulai timbul pada persalinan kala I fase aktif dan makin lama nyeri yang dirasakan akan bertambah kuat. Kontraksi uterus merupakan salah satu yang mengakibatkan nyeri. Kecemasan dan rasa nyeri merupakan masalah yang alamiah dalam menghadapi persalinan. Murottal Al-qur’an merupakan salah satu metode yang memiliki pengaruh positif bagi pendengarnya. Tujuan penelitian ini untuk mengetahui pengaruh terapi murottal Al-qur’an terhadap penurunan intensitas nyeri dan tingkat kecemasan pada ibu bersalin multipara kala I fase aktif. Penelitian ini menggunakan metode quasi experimen dengan rancangan one grup pre-test post-tets design pada 20 ibu bersalin sebagai responden. Terapi murottal Al-qur’an berupa surat Ar-rahmaan diperdengarkan selama 30 menit. Instrument penelitian menggunakan alat ukur Numerik Rating Scale (NRS) dan Hamilton Anxiety Rating Scale (HARS). Analisis data menggunakan paired sample t-test dengan nilai ?= 0,05. Hasil penelitian menunjukan rata-rata skor intensitas nyeri sebelum diberikan terapi murottal Al-qur’an adalah 7,10 setelah diberikan adalah 4,75. Rata-rata skor kecemasan sebelum diberikan terapi Murottal Al-qur’an adalah 22,20 setelah diberikan adalah 12,75. Hasil paired sample t-test menghasilkan nilai signifikan (2-tailed) 0,000. Simpulan pada penelitian ini adalah terdapat perbedaan signifikan skor penurunan rata-rata intensitas nyeri dan tingkat kecemasan ibu sebelum dan setelah dilakukan terapi murottal Al-qur’an. Diharapkan bidan dapat mengedukasi terapi murottal Al-qur’an kepada ibu bersalin, suami, atau keluarga untuk menurunkan intensitas nyeri dan tingkat kecemasan.

Kata kunci: Murottal Al-qur’an, Nyeri, Kecemasan, Persalinan.
Gambaran Kebutuhan Seksual dan Coping Seksual di Lembaga Pemasyarakan Kerobokan Denpasar
Authors: Dewa Ayu Lingga Adi Sawitri
Published: May 2023

Lembaga pemasyarakatan merupakan tempat para kaum pria dan wanita terpisah. kehidupan di lembaga pemasyarakatan dengan kebebasan yang serba terbatas, terutama dalam hal penyaluran kebutuhan seksual.  Tujuan penelitian ini adalah untuk mengetahui persepsi warga binaan tentang kebutuhan seksual dan coping di Lapas Kerobokan Denpasar. Penelitian ini merupakan kualitatif deskriptif, data yang diperoleh melalui wawancara dengan empat (4) informan. Hasil penelitian menunjukkan bahwa responden selama berada di lapas Kerobokan Denpasar  menerima keadaan, berlapang dada, berkomunikasi. Untuk mengalihkan kebutuhan seksual saat di lapas, responden melakukan metode problem focused coping dan problem focused coping emotion, dan tidak ada yang menerapkan maladaptive coping
DAMPAK PENGAWET PARABEN TERHADAP KESEHATAN MANUSIA: LITERATURE REVIEW
Authors: Fathimah Effendy Nur Amalia
Published: May 2023

Parabens are one of the most common preservatives used in products circulating in the community. Parabens are used not only alone but can be combined with other parabens. Parabens can enter the human body through the skin and parenterally. Average total daily paraben exposure is estimated at 76 mg, with cosmetics and personal care products reaching 50 mg, 25 mg from pharmaceutical products, and 1 mg from food. Based on BPOM regulation Number 18 of 2015 concerning technical requirements for preservatives, the limit for single parabens used is 0.14% and mixed parabens is 0.8%. If it exceeds these provisions, it will cause skin irritation and allergies. The method in this research is a literature study sourced from Google Scholar and Pubmed with the year of publication of the literature for the last 10 years in the range of 2012 to 2022. The results of this study discuss how the impact of parabens on human health is found that parabens have a role in obesity, increased asthma reports, affect the menstrual cycle, genotoxic effects, cytotoxic effects, and breast.
Small Cell Carcinoma of the Cervix: A Case Report and Literature Review
Authors: Chen Xi , Mamady Keita , Li Zilin , Fang Zhaohui , Bangaly Traore , Liu Hong
Published: May 2023

Cervical small cell carcinoma (SCC) is a rare disease, with a high degree of malignancy and a poor prognosis. Para-aortic lymph nodes (PALN) are frequent sites of recurrence after pelvic chemoradiotherapy. In the present study, we report the case of a 26-year-old female patient with cervical SCC who suffered for two times PALN relapses. Our research results have shown that PALN lesions can be effectively controlled with permanent radiation therapy. Prophylactic PALN radiotherapy may be an effective option for patients with cervical SCC who require radical pelvic radiation therapy.
An Alternative Method for the Gamma Function derived from Natural Logarithm and Pi Function
Authors: Annamalai Chinnaraji
Published: May 2023

Several professors of mathematics from the renowned universities in Australia, Canada, Europe, India, USA, etc. argue with me that the gamma function was not derived from the factorial function. For them, this paper presents the derivation of gamma function from the natural logarithm and Euler’s factorial function. Also, a novel factorial theorem, which is alternative to the gamma function, is introduced in this article and it computes the accurate values of factorial for positive real numbers.
Quantitative assessment of micronuclei in oral exfoliative buccal squamous cells in smokers, chewers and healthy individuals using Giemsa Stain and Papainicolous Stain
Authors: Joshi Bharath , Kattappagari Kiran Kumar , Lingamaneni Krishna Prasad , Baddam Venkat Ramana Reddy
Published: May 2023

Context: The main reason for oral cancer is tobacco consumption in various forms, such as chewing and smoking. Micronuclei in oral exfoliated cells are markers of chromosomal damage caused by toxic genetic agents from tobacco-related substances, alcohol, etc. The number of micronuclei indicates the cell's genotoxic effect and can be used as a biomarker to assess the changes in the cellular changes. Recently research is focused on determining early genotoxicity changes using exfoliative cytology in human buccal epithelial cells.

Aim: Quantitative analysis of micronuclei in oral exfoliated oral, buccal mucosal cells using Papainicolous stain with Giemsa stain in tobacco users in the form of chewing and smoking in comparison with healthy individuals.

Materials and methods: A total of seventy-five cases were selected for this study. Among seventy-five participants divided into three groups based on habits tobacco smokers (n=25), tobacco chewers (n=25), and healthy individuals (n=25).

Results: The mean number of micronuclei in Giemsa stain was 255.2 ± 78 compared with PAP stain155.12 ± 78.5. The increased mean number of micronuclei in chewers 273.24 ± 80.7, and different stain comparison Giemsa stain showed highest in chewers. A mean number of micronuclei showed statistically highly significant (p≤0.05). Pair-wise comparison of micronuclei inter and intra groups in all three groups, smokers and chewers showed highly statistically substantial (p≤ 0.0001) compared with healthy individuals.

Conclusion: Micronuclei provide evidence that consumption of smokeless tobacco may be developing oral cancer, and micronuclei assay can be used as biomarkers of genotoxicity and carcinogenesis progression.

Key word: Cytological smear, Genotoxicity, Micronuclei, Oral cancer, Tobacco chewers
Deletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum
Authors: Nwaokorie Ugochi Jennifer , Reinmets Kristina , de Lima Lorena Azevedo , Pawar Pratik Rajendra , Shaikh Kurshedaktar Majibullah , Harris Audrey , Köpke Michael , Valgepea Kaspar
Published: May 2023

Gas fermentation has emerged as a sustainable route to produce fuels and chemicals by recycling inexpensive one-carbon (C1) feedstocks from gaseous and solid waste using gas-fermenting microbes. Currently, acetogens that utilise the Wood-Ljungdahl pathway to convert carbon oxides (CO and CO2) into valuable products are the most advanced biocatalysts for gas fermentation. However, our understanding of the functionalities of the genes involved in the C1-fixing gene cluster and its closely-linked genes is incomplete. Here, we investigate the role of two genes with unclear functions—hypothetical protein (hp; LABRINI_07945) and CooT nickel binding protein (nbp; LABRINI_07950)—directly adjacent and expressed at similar levels to the C1-fixing gene cluster in the gas-fermenting model-acetogen Clostridium autoethanogenum. Targeted deletion of either the hp or nbp gene using CRISPR/nCas9, and phenotypic characterisation in heterotrophic and autotrophic batch and autotrophic bioreactor continuous cultures revealed significant growth defects and altered by-product profiles for both ∆hp and ∆nbp strains. Variable effects of gene deletion on autotrophic batch growth on rich or minimal media suggest that both genes affect the utilisation of complex nutrients. Autotrophic chemostat cultures showed lower acetate and ethanol production rates and higher carbon flux to CO2 and biomass for both deletion strains. Additionally, proteome analysis revealed that disruption of either gene affects the expression of proteins of the C1-fixing gene cluster and ethanol synthesis pathways. Our work contributes to a better understanding of genotype-phenotype relationships in acetogens and offers engineering targets to improve carbon fixation efficiency in gas fermentation.
BIM for FM: understanding information quality issues in terms of compliance with owner’s Building Information Modeling Requirements
Authors: Tsay Gustavo S. , Staub-French Sheryl , Poirier Erik , Zadeh Puyan , Pottinger Rachel
Published: May 2023

The promise of Building Information Modeling (BIM) for Facilities Management (FM) is based upon building information models as reliable sources of information for decisions during a facility’s life cycle, from the planning to end of life. However, the premise of BIM as an enabler for the delivery of reliable information for FM has numerous challenges. Previous studies have shown that the quality of information provided through current design practices with BIM is inadequate for FM. These information quality (IQ) issues are mostly related to incomplete, inaccurate, inconsistent, and unintelligible facility information that ultimately reduce the usefulness of BIM-based information for FM purposes. In order to support BIM-enabled delivery of useful asset information for FM, certain IQ criteria must be met. Based on three ethnographic case studies, including the analysis of more than two thousand documented BIM for FM-related compliance issues, this research identifies ten key IQ criteria in design BIMs that must be considered to reliably support BIM use for FM, correlates these IQ criteria with key IQ dimensions identified in the literature to reflect their frequency of occurrence, and identifies sources of IQ issues in BIM for FM within design practice. A mixed-method approach for data collection from the case studies is adopted, including document analysis, semi-structured interviews, meeting observation, and a survey. The data collected are analyzed through an iterative coding process, in which the themes emerged are refined and tested as part of a grounded theory approach. This study contributes to the development of the theoretical concept of IQ in BIM for FM that is grounded in data from actual projects with stringent BIM requirements for FM and thorough compliance processes. As a practical contribution, the findings in this study should enable owners and designers to develop a more optimized asset information delivery process, increasing the value of the information in design BIMs for operations with minimal impact on current modeling practices.
Qualitative lysine crotonylation and 2-hydroxyisobutyrylation analysis in the ovarian tissue proteome of piglets
Authors: Yang Diqi , Li Xiaoping , Yu Beibei , Peng Hui
Published: May 2023

Ovarian function influences diverse aspects of fertility and reproductive lifespan by regulating oocyte supply and hormone secretion. Lysine crotonylation (Kcr) and lysine 2-hydroxyisobutyryllysine (Khib) are newly identified post-translational modifications and function as regulators of transactivation in mammals. In this study, we investigated protein post-translational Kcr and 2-hydroxyisobutyrylation in the ovarian tissues of piglets. A total of 653 overlapping proteins among differentially modified proteins were identified for both crotonylation and 2-hydroxyisobutyrylation. Gene Ontology enrichment analysis indicated that 653 DMPs were significantly enriched in nucleosome organization, chromatin assembly, DNA packaging, peptide biosynthetic process and peptide metabolic process. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed enrichment in proteasome, ribosome, fatty acid elongation, pyruvate metabolism and pentose phosphate pathway. Fifteen DMPs were identified in the proteasome pathway, of which PSMC6 and PSMB7 were the core proteins. In addition, the significant changes in Kcr and Khib in the complex subunits of the proteasome may be involved in cell cycle processes during oocyte development. Forty-four DMPs with both Kcr and Khib modifications were related to the ribosome pathway. The regulated ribosome pathway may indicate that Kcr and Khib comodified proteins participate in protein synthesis during oocyte development. Western blot and immunofluorescence staining results supported the reliability of the sequencing results. Our results may provide a valuable resource to help illuminate the roles of Kcr and Khib in ovarian development and may serve as new tools to better control diseases.
Time-series prediction and detection of potential pathogens in bloodstream infection using mcfDNA sequencing
Authors: Cao Yinghao , Jiang Tingting , Lin Yanfeng , Fang Xiaofeng , Ding Peipei , Song Hongbin , Li Peng , Li Yanjun
Published: May 2023

Introduction

Next-generation sequencing of microbial cell free DNA (mcfDNA-seq) has emerged as a promising diagnostic method for blood stream infection (BSI) and offers the potential to detect pathogens before blood culture. However, its application is limited by a lack of clinical validation.

Methods

We conducted sequential mcfDNA-seq on blood samples from ICU participants at high risk of BSI due to pneumonia, or intravascular catheterization; and explored whether mcfDNA-seq could diagnose and detect pathogens in advance of blood culture positivity. Blood culture results were used as evaluation criteria.

Results

A total of 111 blood samples were collected during the seven days preceding and on the day of onset of 16 BSI episodes from 13 participants. The diagnostic and total predictive sensitivity of mcfDNA-seq were 90% and 87.5%, respectively. The proportion of pathogenic bacteria was relatively high in terms of both diagnosis and prediction. The reads per million of etiologic agents trended upwards in the days approaching the onset of BSI.

Discussion

Our work found that mcfDNA-seq has high diagnostic sensitivity and could be used to identify pathogens before the onset of BSI, which could help expand the clinical application of mcfDNA-seq.
Elevated pulse pressure and cardiovascular risk associated in Spanish population attended in primary care: IBERICAN study
Authors: Moyá-Amengual Ana , Ruiz-García Antonio , Pallarés-Carratalá Vicente , Serrano-Cumplido Adalberto , Prieto-Díaz Miguel Ángel , Segura-Fragoso Antonio , Cinza-Sanjurjo Sergio ,   the researchers of the IBERICAN study
Published: May 2023

Introduction

Elevated pulse pressure (ePP) is an independent marker of cardiovascular risk (CVR) in people older than 60, and a functional marker of subclinical target organ damage (sTOD) which can predict cardiovascular events in patients with hypertension (HTN), regardless of sTOD.

Objective

To evaluate the prevalence of ePP in adult population seen in primary care and its association with other vascular risk factors, sTOD and with cardiovascular disease (CVD).

Materials and methods

Observational multicentre study conducted in Spain (8,066 patients, 54.5% women) from the prospective cohort study IBERICAN recruited in Primary Care. Pulse pressure (PP) was defined as the difference between the systolic blood pressure (SBP) and the diastolic blood pressure (DBP) ≥60 mmHg. Adjusted (for age and sex) ePP prevalence were determined. Bivariate and multivariate analyses of the possible variables associated with ePP were carried out.

Results

The mean of PP was 52.35 mmHg, and was significantly higher (p < 0.001) in patients with HTN (56.58 vs. 48.45 mmHg) The prevalence of ePP adjusted for age and sex was 23.54% (25.40% men vs. 21.75% women; p < 0.0001). The ePP prevalence rates increased linearly with age (R2 = 0.979) and were significantly more frequent in population aged ≥65 than in population aged <65 (45.47% vs. 20.98%; p < 0.001). HTN, left ventricular hypertrophy, low estimated glomerular filtration rate, alcohol consumption, abdominal obesity, and CVD were independently associated with ePP. 66.27% of patients with ePP had a high or very high CVR, as compared with 36.57% of patients without ePP (OR: 3.41 [95% CI 3.08–3.77]).

Conclusions

The ePP was present in a quarter of our sample, and it was increased with the age. Also, the ePP was more frequent in men, patients with HTN, other TOD (as left ventricular hypertrophy or low estimated glomerular filtration rate) and CVD; because of this, the ePP was associated a higher cardiovascular risk. In our opinion, the ePP is an importer risk marker and its early identification lets to improve better diagnostic and therapeutic management.