bluuebunny/crossref_metadata_2025 huggingface dataset:
Bigger DNA: New Double Helix with Expanded Size
Authors: Marx Andreas , Summerer Daniel
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
The Mechanism of Heterogeneous “Self‐Cleaning” of the Coastal Troposphere: May This Phenomenon Have “Explosion‐like” Autocatalytic Character?
Authors: Gershenzon M. Yu. , Grigorieva V. M. , Shestakov D. V. , Zelenov V. V. , Gershenzon Yu. M. , Zellner R.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Nanotubes by Template Wetting: A Modular Assembly System
Authors: Steinhart Martin , Wehrspohn Ralf B. , Goesele Ulrich , Wendorff Joachim H.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Microflow Reaction Systems for Combinatorial Syntheses
Authors: Kikutani Yoshikuni , Kitamori Takehiko
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Soft‐Positioning with Ferrofluids
Authors: Uhlmann Eckart , Bayat Nayim
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Can TNM Derail Your Beneficial Use Program?
Authors: Scanlan Patricia , Naylor Lew , Bunn Don
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Geometric and Electronic Control of Thermal Bergman Cyclization
Authors: Rawat Diwan S. , Zaleski Jeffrey M.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Heisenberg Model and Its Applications to π‐Conjugated Systems
Authors: Li Shuhua , Ma Jing , Jiang Yuansheng
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Mechanism of Interfacial Exchange Phenomena for Proteins Adsorbed at Solid—Liquid Interfaces
Authors: Ball Vincent , Schaaf Pierre , Voegel Jean‐Claude
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Automatic Analysis of NMR Spectra
Authors: Griffiths Lee
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Amino Acids and Their Derivatives
Authors: Bhushan Ravi , Martens J.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
MAS Solid‐State NMR of Isotopically Enriched Biological Samples
Authors: Williamson Philip T. F. , Ernst Matthias , Meier Beat H.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Electron Paramagnetic Resonance Spectroscopy
Authors: Eaton G. R. , Eaton S. S.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Enantioselective transport and liquid–liquid extraction of amino acids as their potassium and sodium salts by optically active diaza‐18‐crown‐6 ethers
Authors: Demirel Nadir , Bulut Yasemin , Hoşgören Halil
Published: May 2004

Complexation of amino acids as their sodium and potassium salts by optically active diaza crown ethers has been investigated in transport across bulk liquid membranes containing the carriers and in extraction experiments. The observed enantioselectivity was achieved by (noncovalent) steric and repulsive interactions between the side arm of the crown ether and functional group(s) of the amino acids. The highest enantioselectivity was observed in the case of tryptophan. Chirality 16: 347–350, 2004. © 2004 Wiley‐Liss, Inc.
Enantioselective recognition of ammonium perchlorate salts by optically active monoaza‐15‐crown‐5 ethers
Authors: Togrul Mahmut , Turgut Yilmaz , Hoşgören Halil
Published: May 2004

Chiral monoaza‐15‐crown‐5 ethers (1, 2) were prepared from (R)‐(−)‐2‐amino‐1‐butanol in high yield. The chiral monoaza‐15‐crown‐5 ethers were purified directly as NaClO4 complexes. Molecular recognition by these chiral monoaza‐crown ethers of (R)‐ and (S)‐PhEtHClO4 and (R)‐ and (S)‐NapEtHClO4 as characterized by UV–vis spectroscopy. The order of enantiomeric selectivity is (R)‐ > (S)‐ PhEtHClO4 and (S)‐ > (R)‐NapEtHClO4 for 1. In the case of 2 it was (R)‐ > (S)‐PhEtHClO4 and (R)‐ > (S)‐ NapEtHClO4. The cavity of macrocycle and steric hindrance of the benzene units appears to play an important role in recognition. Chirality 16:351–355, 2004. © 2004 Wiley‐Liss, Inc.
Preparation of highly optically pure homochiral sulfide‐containing alcohols via oxazaborolidine‐catalyzed asymmetric borane reduction of ketones
Authors: Xu Jiaxi , Wei Tiezheng , Xia Jiakun , Zhang Qihan , Wu Hesong
Published: May 2004

Highly optically pure homochiral 1‐(4‐alkylthiophenyl) alcohols were prepared efficiently and practically via the oxazaborolidine‐catalyzed asymmetric borane reduction of prochiral ketones in toluene at 25°C. The coordination of the sulfur atom in the ketones to the boron atom in the catalyst and borane can be inhibited under these reduction conditions. Chirality 16:341–346, 2004. © 2004 Wiley‐Liss, Inc.
Wände als Wärmespeicher — Modellversuche zu neuen Baustoffen
Authors: Sgoff Dieter , Bader Hans Joachim
Published: May 2004

IM SINNE EINES NACHHALTIGEN Wirtschaftens ist der sparsame Umgang mit Energie ein äußerst wichtiger Gesichtspunkt. Erreicht werden kann dies einmal durch die Vermeidung von Verlusten bei Energieumwandlungsprozessen. Hier ist etwa die Steigerung der Wirkungsgrade von Verbrennungs‐ und Elektromotoren zu nennen. Zum anderen spielt die Verbesserung bekannter Systeme zur Energiespeicherung und die Entwicklung neuer Möglichkeiten eine große Rolle, da Energieproduktion und ‐bedarf besonders bei der Nutzung regenerativer Energien oft nicht parallel laufen. Aber auch die Verringerung des Energieaufwandes durch bessere Wärmedämmung etwa von Gebäuden — streng genommen ebenfalls die Optimierung von Energiespeichern — spielt eine große Rolle.

Im Zusammenhang mit der Erschließung der umrissenen Thematik für den naturwissenschaftlichen Unterricht haben Huntemann et al. kürzlich die Möglichkeiten von Latentwärmespeichern ausführlich dargestellt [1], weshalb hier auf eine allgemeine Übersicht und die Darstellung der Theorie verzichtet werden kann. Die vorliegende Arbeit erweitert und vertieft die Thematik aus schulexperimenteller und anwendungsbezogener Sicht.
Comparative analysis of two C‐terminal kinesin motor proteins: KIFC1 and KIFC5A
Authors: Zhang Yuguo , Sperry Ann O.
Published: May 2004

We have taken advantage of the close structural relationship between two C‐terminal motors, KIFC5A and KIFC1, to examine the sequence requirements for targeting of these two motors within the cell. Although KIFC5A and KIFC1 are almost identical in their motor and stalk domains, they differ in well‐defined regions of their tail domains. Specific antisera to these motors were used to determine their localization to distinct subcellular compartments, the spindle for KIFC5A or membranous organelles for KIFC1. In addition to defining the intracellular localization of KIFC1, the reactivity of the KIFC1 antibody demonstrates that this motor contains a frame shift with respect to KIFC5A and is likely the product of a separate gene. The divergent tail domains of these motors are predicted to harbor specific information that directs them to their correct intracellular targets. In order to define the sequences responsible for the differential localization of these two motors, GFP was fused to motors with various tail deletions and their localization visualized after transfection. We were able to identify distinct sequences in each motor responsible for its unique cellular localization. The KIFC5A tail contains a 43 amino acid sequence with both nuclear localization and microtubule binding activity while KIFC1 contains a 19 amino acid sequence sufficient to target this motor to membrane‐bounded organelles. Cell Motil. Cytoskeleton 58:213–230, 2004. © 2004 Wiley‐Liss, Inc.
Midkine protects hepatocellular carcinoma cells against TRAIL‐mediated apoptosis through down‐regulation of caspase‐3 activity
Authors: Ohuchida Tomoko , Okamoto Kohji , Akahane Kazuhisa , Higure Aiichiro , Todoroki Hidekazu , Abe Yukio , Kikuchi Makoto , Ikematsu Shinya , Muramatsu Takashi , Itoh Hideaki
Published: May 2004

BACKGROUND

It is believed that midkine (MK), a heparin‐binding growth factor, plays an important role in carcinogenesis. However, the biologic mechanism of MK in hepatocellular carcinoma has not been clarified to date. The objective of the current study was to investigate the antiapoptotic role of MK in a human hepatoma cell line.

METHODS

The human hepatoma cell line HepG2 was used to study the antiapoptotic effect of MK. Tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL)/actinomycin D (ActD)–induced apoptosis was detected using a 2‐(2‐methoxy‐4‐nitrophenyl)‐3‐(4‐nitrophenyl)‐5‐(2,4‐disulphophenyl)‐2H‐tetrazolium monosodium salt (WST‐8) assay, a caspase‐3 activity assay, a caspase‐8 activity assay, and flow cytometric analysis.

RESULTS

TRAIL had a potent, dose‐dependent inductive effect on cell death in HepG2 cells, for which viable cell counts decreased to 6.3% of the control count at a TRAIL concentration of 100 ng/mL in the presence of 500 ng/mL ActD. Flow cytometry was used to demonstrate that apoptosis induced by TRAIL/ActD was in fact the cause of cell death. According to the WST‐8 assay, MK pretreatment resulted in the suppression of TRAIL/ActD‐mediated apoptosis in HepG2 cells, although cell viability did not increase when HepG2 cells were treated with MK alone. Caspase‐3 activity was down‐regulated when MK was added, but caspase‐8 activity was high in both the absence and presence of MK.

CONCLUSIONS

The results of the current study indicate that MK acts as an antiapoptotic factor in HepG2 cells through the down‐regulation of caspase‐3 activity. Cancer 2004. © 2004 American Cancer Society.
Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection
Authors: Pedersen‐Bjergaard Ulrik , Pramming Stig , Heller Simon R , Wallace Tara M , Rasmussen Åse K , Jørgensen Hanne V , Matthews David R , Hougaard Philip , Thorsteinsson Birger
Published: May 2004

Background

Differences between studies in rates of severe hypoglycaemia in type 1 diabetic cohorts are common and poorly understood. The purpose of this study was to assess the frequency of severe hypoglycaemia in unselected patients treated in different secondary care centres and to evaluate the influence of risk markers, clinical setting and selection.

Methods

Cross‐sectional Danish–British multicentre survey of 1076 consecutive adult patients with clinical type 1 diabetes who completed a detailed questionnaire on hypoglycaemia and related issues. Key variable was the self‐reported rate of severe hypoglycaemia during the preceding year.

Results

The overall rate of severe hypoglycaemia in the preceding year was 1.3 episodes/patient‐year and episodes were reported by 36.7% of subjects. The distribution was highly skewed with 5% of subjects accounting for 54% of all episodes. There were no significant differences between countries or centres. Reduced hypoglycaemia awareness, peripheral neuropathy and smoking were the only significant risk markers of severe hypoglycaemia in a stepwise multivariate analysis. In a subgroup selected to be similar to the Diabetes Control and Complications Trial (DCCT) cohort, the rate of severe hypoglycaemia was 0.35 episodes/patient‐year and only retinopathy was a significant risk marker together with state of awareness.

Conclusion

Severe hypoglycaemia remains a significant clinical problem in type 1 diabetes. The rate of severe hypoglycaemia and the influence of risk markers are very sensitive to selection and differences in rates between centres or studies seem to disappear after correction for differences in clinical characteristics. Smoking is a novel overall risk marker of severe hypoglycaemia. Copyright © 2004 John Wiley & Sons, Ltd.
Regional distribution of α9β1 integrin within the limbus of the mouse ocular surface
Authors: Pajoohesh‐Ganji Ahdeah , Ghosh Sonali Pal , Stepp Mary Ann
Published: May 2004

The epithelial basal cells of the corneal limbus are known to contain adult corneal epithelial stem cells, but the properties of these cells are not well understood. In addition, how and when the limbal epithelium forms during postnatal development in mammals is not clear. To better understand the anatomy and cell biology of the limbus, a whole‐mount procedure was used to show that the nasal, inferior, temporal, and superior regions of the mouse limbus contain different numbers of α9 integrin–positive cells most of which are observed in the nasal region. We also show that this pattern develops progressively over time from 1 to 8 weeks after birth. High magnification image projections and three‐dimensional reconstructions of the limbal region were generated from confocal images obtained after tissues were dual stained with α9 integrin and propidium iodide (PI) or triple stained with α9 integrin, E‐cadherin, and PI. Data show that α9 integrin is present on the adult mouse cornea in the limbal basal cells and is more abundant in the apical‐most cytoplasm of the limbal basal cells, where it can be found colocalized within the plasma membrane with E‐cadherin. These studies are an important step toward improving our understanding of the development and cell biology of limbal basal cells. Developmental Dynamics 230:518–528, 2004. © 2004 Wiley‐Liss, Inc.
Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish
Authors: Gillhouse Matthew , Wagner Nyholm Molly , Hikasa Hiroki , Sokol Sergei Y. , Grinblat Yevgenya
Published: May 2004

Members of the Wnt family of extracellular proteins play essential roles during many phases of vertebrate embryonic development. The molecular mechanism of their action involves a complex cascade of intracellular signaling events, which remains to be understood completely. Recently, two novel cytoplasmic modulators of Wnt signaling, Frodo and Dapper, were identified in Xenopus. We report isolation of their homologs in zebrafish, and show that these genes, frd1 and frd2, are expressed in restricted domains during embryogenesis. Both genes are expressed during early gastrulation in the future mesendoderm, and continue to be expressed in distinct patterns in the forming neurectoderm and mesoderm. Comparative sequence analysis and similar expression patterns argue that frd1 is the zebrafish ortholog of Frodo and Dapper, whereas frd2 is a more divergent member of the same family. Our data suggest important roles for zebrafish frd1 and frd2 in patterning the neural plate and several mesodermal derivatives. Developmental Dynamics 230:403–409, 2004. © 2004 Wiley‐Liss, Inc.
Basic leucine zipper transcription factors C/EBP and MafL in the hydrozoan jellyfish Podocoryne carnea
Authors: Seipel Katja , Yanze Nathalie , Müller Peter , Streitwolf Ruth , Schmid Volker
Published: May 2004

Members of the CCAAT/enhancer binding protein (C/EBP) and the Maf protein subfamilies have been characterized in a variety of bilaterian organisms. This is the first report of C/EBP and MafL genes in a basal organism, the hydrozoan jellyfish Podocoryne carnea. Transcripts of both genes are present in all life cycle stages: egg, embryo, larva, polyp, and medusa. During early development, both factors appear to regulate metamorphosis of the larva to the primary polyp. Both genes are also expressed in the striated muscle of the developing and adult medusa. During in vitro transdifferentiation of striated muscle cells to smooth muscle and nerve cells, C/EBP is continuously expressed, whereas MafL expression is turned off during transdifferentiation and reactivated when nerve cells differentiate. Thus, both factors may be involved in muscle and nerve cell differentiation. In the mature medusa both genes are also implicated in gametogenesis. Developmental and evolutionary aspects of the gene structures and expression patterns are discussed. Developmental Dynamics 230:392–402, 2004. © 2004 Wiley‐Liss, Inc.
Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis
Authors: Ruiz Sergio , Segrelles Carmen , Santos Mirentxu , Lara M. Fernanda , Paramio Jesús M.
Published: May 2004

The retinoblastoma family of proteins (pRb, p107, and p130) modulates cell cycle progression and differentiation of several tissues. We have demonstrated recently that p107 and p130 regulate keratinocyte terminal differentiation and hair follicle morphogenesis and development in vivo. This last aspect appears to be mediated by defective signaling from the mesenchyme and is associated with altered bone morphogenetic protein‐4 (BMP4) ‐dependent signaling. However, many alterations were also found in the epithelial compartment. Given the importance of βcatenin in hair biology and in BMP signaling, we studied its expression in p107/p130‐deficient skin. Although normal expression of βcatenin was found in p107/p130‐deficient hair follicles, we found increased nuclear accumulation of βcatenin in the basal keratinocytes of the p107/p130‐deficient mice skin. Biochemical analysis revealed that such an increase in βcatenin was due to the disruption of Axin/GSK3β/βcatenin complexes promoted by the increased expression of Frat, the mouse homologue of GSK3βbinding protein (GBP), in epidermis, precluding the degradation of βcatenin. Collectively, these data represent the first evidence that retinoblastoma family and Wnt signaling pathways might be interconnected by functional links in skin. Developmental Dynamics 230:410–418, 2004. © 2004 Wiley‐Liss, Inc.
Genetic interactions underlying otic placode induction and formation
Authors: Solomon Keely S. , Kwak Su‐Jin , Fritz Andreas
Published: May 2004

The formation of the otic placode is a complex process requiring multiple inductive signals. In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest‐acting genes in this process. fgf3 and fgf8 are required as inductive signals, whereas dlx3b, dlx4b, and foxi1 appear to act directly within otic primordia. We have investigated potential interactions among these genes. Depletion of either dlx3b and dlx4b or foxi1 leads to a delay of pax2a expression in the otic primordia and reduction of the otic vesicle. Depletion of both foxi1 and dlx3b results in a complete ablation of otic placode formation. A strong synergistic interaction is also observed among foxi1, fgf3, and fgf8, and a weaker interaction among dlx3b, fgf3, and fgf8. Misexpression of foxi1 can induce expression of pax8, an early marker for the otic primordia, in embryos treated with an inhibitor of fibroblast growth factor (FGF) signaling. Conversely, morpholino knockdown of foxi1 blocks ectopic pax8 expression and otic vesicle formation induced by misexpression of fgf3 and/or fgf8. The observed genetic interactions suggest a model in which foxi1 and dlx3b/dlx4b act in independent pathways together with distinct phases of FGF signaling to promote otic placode induction and development. Developmental Dynamics 230:419–433, 2004. © 2004 Wiley‐Liss, Inc.
Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade
Authors: Kamimura Mika , Matsumoto Ken , Koshiba‐Takeuchi Kazuko , Ogura Toshihiko
Published: May 2004

In vertebrates and invertebrates, BMP/Dpp (Bone Morphogenetic Protein/Decapentaplegic) signaling regulates the orchestrated processes of embryogenesis. Recent studies have revealed that BMP/Dpp signaling is controlled extracellularly as well as intracellularly. One extracellular regulatory molecule is the Chordin/Short gastrulation protein (Chordin/Sog), a secreted protein that acts as an antagonist to BMP/Dpp. Chordin/Sog contains four cysteine‐rich (CR) domains that bind to and inactivate BMP/Dpp. In contrast, a positive regulator has been identified in Drosophila. Named crossveinless 2 (cv‐2), this molecule contains five CR domains at the N‐terminal half and a von Willebrand factor D domain at the C‐terminal part. Genetic data suggest that Cv‐2 potentiates Dpp signaling. We isolated chick and mouse CV‐2 genes and found that CV‐2 is secreted and enhances BMP signaling. Expression patterns were closely related to those of BMPs, supporting the likelihood of a tight link. Our data show for the first time that CV‐2 is a conserved, positive regulator of BMP signaling and that CR domain proteins act as both positive and negative modulators of BMP signaling. Developmental Dynamics 230:434–445, 2004. © 2004 Wiley‐Liss, Inc.
Msx1 disruption leads to diencephalon defects and hydrocephalus
Authors: Ramos Casto , Fernández‐Llebrez Pedro , Bach Antoine , Robert Benoît , Soriano Eduardo
Published: May 2004

We have analyzed the expression of the Msx1 gene in the developing mouse brain and examined the brain phenotype in homozygotes. Msx1 is expressed in every cerebral vesicle throughout development, particularly in neuroepithelia, such as those of the fimbria and the medulla. Timing analysis suggests that Msx1nLacZ cells delaminate and migrate radially from these epithelia, mainly at embryonic days 14–16, while immunohistochemistry studies reveal that some of the β‐galactosidase migrating cells are oligodendrocytes or astrocytes. Our results suggest that the Msx1 neuroepithelia of fimbria and medulla may be a source of glial precursors. The Msx1 mutants display severe hydrocephalus at birth, while the subcommissural organ, the habenula, and the posterior commissure fail to develop correctly. No label was detected in the mutant subcommissural organ using a specific antibody against Reissner's fiber. Besides, the fasciculus retroflexus deviates close to the subcommissural organ, while the paraventricular thalamic nucleus shows histological disorganization. Our results implicate the Msx1 gene in the differentiation of the subcommissural organ cells and posterior commissure and that Msx1 protein may play a role in the pathfinding and bundling of the fasciculus retroflexus and in the structural arrangement of the paraventricular thalamic nucleus. Developmental Dynamics 230:446–460, 2004. © 2004 Wiley‐Liss, Inc.
Independent induction and formation of the dorsal and ventral fins in Xenopus laevis
Authors: Tucker A.S. , Slack J.M.W.
Published: May 2004

It has been known since the 1930s that the dorsal fin is induced by the underlying neural crest. The inducer of the ventral fin, however, has remained elusive. We have investigated the source of the inducer of the ventral fin in Xenopus and show that it is the ventral mesoderm and not the neural crest. This induction takes place during mid‐neurula stages and is completed by late neurulation. In terms of cell composition, the dorsal fin mesenchyme core arises from neural crest cells, while the mesenchyme of the ventral fin has a dual origin. The ventral fin contains neural crest cells that migrate in from the dorsal side of the embryo, but a contribution is also made by cells from the ventral mesoderm. Developmental Dynamics 230:461–467, 2004. © 2004 Wiley‐Liss, Inc.
Influence of endostatin on embryonic vasculo‐ and angiogenesis
Authors: Schmidt Annette , Wenzel Daniela , Ferring Isabell , Kazemi Shohreh , Sasaki Takako , Hescheler Jürgen , Timpl Rupert , Addicks Klaus , Fleischmann Bernd K. , Bloch Wilhelm
Published: May 2004

The proteolytic fragment of collagen XVIII, endostatin, acts as an inhibitor of angiogenesis. To date, only limited knowledge exists on the effects of endostatin on endothelial cells during embryonic development. Therefore, we analysed the role of endostatin on embryonic vasculo‐ and angiogenesis. Endostatin is accumulated in embryonic tissue of mouse embryos. Similarly, in vessels of embryoid bodies (EBs), endostatin and its binding sites are distributed in vessels and sprouting areas. In EBs, endostatin increases endothelial cells (control, 279.3 ± 76.5; 50 ng/ml, 566.3 ± 90.1; 200 ng/ml, 594.5 ± 166.3 tube‐like structures per EB) and endothelial tubes by proliferation (control, 21.4 ± 7.5; 50 ng/ml, 160.2 ± 9.9; 200 ng/ml, 184.2 ± 16.5 Ki67‐positive nuclei per 50 tube‐like structures); it also enhances migration (control, 380.5 ± 159.8 cells; 50 ng/ml, 718.3 ± 251 cells; 200 ng/ml, 706 ± 89.4 cells) and apoptosis (control, 16.8 ± 6.7; 50 ng/ml, 94.4 ± 23.6; 200 ng/ml, 106 ± 42 PARP‐positive nuclei per 50 tube‐like structures). Furthermore, endostatin modulates the morphology of the endothelial tubes by inducing contraction. Endostatin modulates the embryonic vascular development by enhancing proliferation, migration, and apoptosis as well as by regulating morphogenesis. Developmental Dynamics 230:468–480, 2004. © 2004 Wiley‐Liss, Inc.
Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish
Authors: Boehmler Wendy , Obrecht‐Pflumio Sophie , Canfield Victor , Thisse Christine , Thisse Bernard , Levenson Robert
Published: May 2004

We mined the zebrafish genomic sequence database and identified contigs containing segments of several dopamine receptor genes. By using a polymerase chain reaction amplification strategy, we generated full‐length cDNAs encoding a single dopamine D3 receptor and three distinct D2 receptor subtypes. Zebrafish dopamine receptor genes were mapped by using the T51 radiation hybrid panel. The D3 receptor gene (drd3) mapped to linkage group (LG) 24. The three D2 receptor genes were localized to LG 15 (drd2a), LG 16, (drd2b), and LG 5 (drd2c). With the exception of the drd2b gene, each of these map positions was syntenic with regions of human chromosomes containing orthologs of the zebrafish dopamine receptor genes. Whole‐mount in situ hybridization was used to investigate expression of the D2 and D3 receptor genes. Expression of the drd3 gene was first detected at mid‐somitogenesis and was particularly prominent in somites. Thereafter, the drd3 gene was expressed diffusely throughout the brain and spinal cord. The three D2 receptor genes were expressed throughout the central nervous system (CNS) in distinct but overlapping patterns. In early embryos, the drd2a gene was expressed exclusively in the epiphysis, whereas the drd2c gene was localized to the notochord. After 24 hpf, the drd2a, drd2b, and drd2c genes were differentially expressed throughout the CNS. The identification of dopamine receptor genes in zebrafish should allow us to use the power of zebrafish genetics to analyze the functional properties of this important class of neurotransmitter receptors. Developmental Dynamics 230:481–493, 2004. © 2004 Wiley‐Liss, Inc.
Interleukin‐5 participates in the pathogenesis of ileitis in SAMP1/Yit mice
Authors: Takedatsu Hidetoshi , Mitsuyama Keiichi , Matsumoto Satoshi , Handa Kazuyo , Suzuki Asuka , Takedatsu Hiroko , Funabashi Hideyuki , Okabe Yoshio , Hara Taeko , Toyonaga Atsushi , Sata Michio
Published: May 2004

SAMP1/Yit mice spontaneously develop ileitis resembling Crohn's disease (CD) without chemical or genetic manipulations. Since the focus of studies were Th1 cytokines, only Th1‐type T cells were thought to be responsible for intestinal inflammation in these mice. To further characterize the pathogenesis of this ileitis, we investigated the implication of Th2 cytokines in ileitis of SAMP1/Yit mice. The expression of chemokine receptors (CCR) associated with both Th1 and Th2 lymphocytes, such as CCR2, CCR3, CCR4, CCR5, and CCR8, was increased. Among cytokines, IL‐5 was remarkablyincreased in Peyer's patches, mesenteric lymph nodes, and mucosa involved in ileitis. Furthermore, infiltration of numerous eosinophils in ileitis was histologically evident. Severe combined immunodeficiency mice injected intraperitoneally with CD4+ cells from SAMP1/Yit mice developed colitis and ileitis, with the infiltration of eosinophils. Administration of anti‐IL‐5 antibodies significantly attenuated ileitis in these mice. We suggest that IL‐5 participates in the pathogenesis of ileitis and that anti‐IL‐5 antibodies are potentially useful for immunotherapy in CD patients. This is the first demonstration that IL‐5 is crucial for the development of ileitis in this mouse model of CD.
The First Cyclometallated (1‐Ferrocenylethanone thiosemicarbazone)palladium(II) Compounds − Crystal and Molecular Structure of [Pd{(η5‐C5H5)Fe(η5‐C5H3)C(Me)=NN=C(S)NHMe}(PPh3)]
Authors: Vila José M. , Gayoso Eduardo , Pereira M. Teresa , Ortigueira Juan M. , Alberdi Gemma , Mariño Marta , Alvarez Reyes , Fernández Alberto
Published: May 2004

Treatment of the 1‐ferrocenylethanone thiosemicarbazone ligands (η5‐C5H5)Fe(η5‐C5H4)C(Me)=NN(H)C(=S)NHR [R = H (a), Me (b)] with K2[PdCl4] gave the novel heterometallic octanuclear palladium(II) compounds [Pd{(η5‐C5H5)Fe(η5‐C5H3)C(Me)=NN=C(S)NHR}]4 [R = H (1a), Me (1b)] as tetramers, after deprotonation of the NH group, with the ligands acting as terdentate donors through the [C,N,S] atoms. Treatment with nucleophiles cleaves the tetrameric clusters giving compounds in which splitting only of the Pd−Sbridging bonds has occurred. The strength of the Pd−Schelating bond hinders its cleavage. Thus, treatment of 1a or 1b with Ph2P(CH2)nPPh2 [n = 2 (dppe), 3 (dppp), 4 (dppb)] in a 1:2 molar ratio gave the tetranuclear species 2a−4a and 2b−4b, respectively, and treatment with PPh2R gave the dinuclear compounds 5a−7a and 5b−6b [R = Ph (5a, 5b), Et (6a, 6b), Me (7a)]. The complexes described are the first fully characterized cyclometallated palladium(II) complexes with 1‐ferrocenylethanone thiosemicarbazone ligands. The crystal and molecular structure of compound 5b have been determined by X‐ray crystallography. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
An Energy Dispersive X‐ray Diffraction Study of Dioxouranium(VI) in 1 M Lithium Citrate
Authors: Vasca Ermanno , Palladino Giuseppe , Manfredi Carla , Fontanella Cecilia , Sadun Claudia , Caminiti Ruggero
Published: May 2004

An Energy Dispersive X‐ray Diffraction (EDXD) study of 0.3 M dioxouranium(VI) in 1 M lithium citrate at pH = 5 is reported. The data are in accordance with the existence of a predominately polynuclear complex containing four U atoms, concluded from potentiometric measurements. The uranium atoms lie at the corners of two triangles sharing one edge. Five O atoms surround each uranyl group, the uranium coordination polyhedron being a pentagonal bipyramid; four U atoms are linked through double or single O bridges. The U−U distances are 3.95 Å and 4.65 Å. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
One‐Dimensional CdIICoordination Polymers: Solid Solutions with NiII, Thermal Stabilities and Structures
Authors: Vujovic Dejana , Raubenheimer Helgard G. , Nassimbeni Luigi R.
Published: May 2004

Reactions of Cd(NCS)2with 2‐, 3‐ and 4‐aminobenzonitrile ligands (2ABN, 3ABN and 4ABN respectively) have produced one‐dimensional chain polymers of the general formula [M(NCS)2(ABN)2]nwith the metal centres linked by double NCS−bridges. The three cadmium polymers [Cd(NCS)2(3ABN)2]n(1), [Cd(NCS)2(2ABN)2]n(2) and [Cd(NCS)2(4ABN)2]n(3) all differ in their hydrogen‐bonding patterns. In terms of ABN coordination, both1and2exhibit terminal amine coordination while in3the ABNs are coordinated through the cyano groups. Crystalline solid solutions of1of general formula [Cd1−xNix(NCS)2(3ABN)2]n, containing nickel and cadmium in varying proportions, have also been prepared in order to establish the influence of the metal ratio on the thermal stability and bonding parameters of the polymers. The coordination polymers are not good candidates for forming clathrates while their thermal stability (ranging between 147 and 244 °C) depends on the position of functional groups on the ABN ligands and on the Cd:Ni ratio in the solid solutions. The new polymers have been characterised by single crystal X‐ray diffraction, X‐ray powder diffraction, electron microscopy, infrared spectroscopy, thermogravimetry and differential scanning calorimetry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis and Structural Characterization of Monomeric Manganese(II) N‐Heterocyclic Carbene Complexes [MnX2(C{N(iPr)C(Me)}2)2] (X = Cl, I, and MeCOO)
Authors: Chai Jianfang , Zhu Hongping , Peng Ying , Roesky Herbert W. , Singh Sanjay , Schmidt Hans‐Georg , Noltemeyer Mathias
Published: May 2004

Reaction of MnCl2(THF)1.5, MnI2, or Mn(MeCOO)2 with two equivalents of N‐heterocyclic carbene [C(Me)N(iPr)]2C (1) in THF at room temperature readily afforded the corresponding carbene adducts [MnX2(C{N(iPr)C(Me)}2)2] [X = Cl (2); X = I (3); X = MeCOO (4)] in good yield. Solid‐state structural analysis of complexes 2−4 reveals that all complexes are monomeric. In complexes 2 and 3 the central manganese atoms are four coordinate and have a distorted tetrahedral geometry. The manganese atom in compound 4 has a coordination number of six and resides in a highly distorted octahedral geometry. The N‐heterocyclic carbene ligands in these complexes are coordinated differently to the central metal atoms. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Metal‐Directed Self‐Assembly: Two New Metal‐Binicotinate Grid Polymeric Networks and Their Fluorescence Emission Tuned by Ligand Configuration
Authors: Wu Benlai , Yuan Daqiang , Jiang Feilong , Wang Ruihu , Han Lei , Zhou Youfu , Hong Maochun
Published: May 2004

Two new 2‐D metal‐binicotinate coordination polymers, namely, [CdII(bpdc)]n (1) and {[ZnII8(bpdc)8(H2O)8](H2O)8}n (2) (H2bpdc = binicotinic acid) have been synthesized using hydrothermal and three‐layer diffusion methods, respectively. Single‐crystal X‐ray analyses revealed that both are extended grid networks of the (4,4) topology. Their structures alter with the configuration and function of bpdc. The achiral, free H2bpdc has axial chirality induced by metal coordination in 1, and bpdc connects to four metal centers forming a 2‐D (4,4) net with three kinds of apertures generated through self‐assembly. In 2, however, bpdc connects to three metal centers, fabricating a microporous framework containing hydrophilic channels. Studies on the solid emission spectra of the free ligand, 1, and 2 confirmed, that the configuration of bpdc resulting from metal‐directed coordination has a profound effect on the fluorescence emissions of 1 and 2. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Covalent Bonding of Phosphonates of L‐Proline and L‐Cysteine to γ‐Zirconium Phosphate
Authors: Huang Kunlin , Yu Jihong , Wang Guangmei , Li Yi , Xu Ruren
Published: May 2004

This paper describes the synthesis and characterization of γ‐zirconium phosphate‐phosphonates based on chiral N‐phosphonomethyl‐L‐proline [(−)‐HO3PCH2NHC4H7CO2H; H3PMP] from L‐proline, and N‐phosphonomethyl‐1,3‐thiazolidine‐4‐carboxylic acid [(−)‐HO3PCH2NHCH2SC2H3CO2H; H3PMTA] from L‐cysteine. Two compounds formulated as [Zr(PO4)(H2PO4)0.53(H2PMP)0.47·2.0H2O] [γ‐ZrPMP (1)] and [Zr(PO4)(H2PO4)0.50(H2PMT)0.50·1.6H2O] [γ‐ZrPMT (2)] were obtained by topotactic reaction of H3PMP and H3PMTA, respectively, with γ‐ZrP in the presence of water/acetone. They possess intercalation capabilities and optical activities. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis and Characterization of Ti Complexes Using 4‐tert‐Butyl‐2,6‐bis(hydroxymethyl)phenol: X‐ray Structures of a Confacial Bioctahedron with Terminal Nucleophilic Phenylmethoxide Ligands, and a Ti4O16 Core Protected by Two Hydrophobic Binding Pockets
Authors: Glaser Thorsten , Liratzis Ioannis , Lügger Thomas , Fröhlich Roland
Published: May 2004

Treatment of 4‐tert‐butyl‐2,6‐bis(hydroxymethyl)phenol (H3L) with [TiO(acac)2] in protic solvents at elevated temperatures leads to the formation of the dinuclear complex (Et4N)[L3Ti2] 1, whereas carrying out the reaction at room temperature or in aprotic solvents leads to the formation of the tetranuclear complex (Et4N)2[L2(HL)4Ti4O2] 2. Heating 2 in protic solvents leads to the formation of 1, but 2 is stable in non‐protic solvents such as THF even upon heating. Dissolving 1 in an aprotic solvent leads to the formation of 2. The anion of 1 consists of a confacial bioctahedron with a [(BzO)3TiIV(μ2‐OPh)3TiIV(OBz)3]− core. The phenylmethoxide ligands (BzO−), and the phenolato ligands are bound to the strong Lewis acid TiIV. The bond lengths are for Ti−OBz ca. 1.83 Å and for Ti−μ2‐OPh ca. 2.11 Å. Despite the highly covalent Ti−OBz bond, the phenylmethoxide ligands exhibit nucleophilic character, and a tendency to bridge two TiIV ions as demonstrated by the synthesis of the tetranuclear complex 2. The dianion in 2 consists of a Ti4O16 core with two hydrophobic half‐bowl shaped pockets built from three tert‐butylbenzene units each. The hydrophobic pockets allow access to the Lewis basic μ3‐O2− ligands of the Ti4O16 core. In the crystal structure of 2·2CH3CN, two Et4N+ cations occupy these two binding pockets. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Novel Bonding Modes between Tetrathiafulvalenes (TTFs) and Transition Metal Centers: π‐Bonding and Covalent TTFSiMe2−MLn Coordination to Platinum
Authors: Jayaswal Mathuresh N. , Peindy Harmel N. , Guyon Fabrice , Knorr Michael , Avarvari Narcis , Fourmigué Marc
Published: May 2004

Two novel strategies for coordinating TTF to transition metal centers have been developed. The reaction of tetrathiafulvalene (TTF) or 3,4‐dimethyltetrathiafulvalene (o‐Me2TTF) with [Pt(η2‐C2H4)(PPh3)2] leads to the π complexes [Pt(η2‐TTF)(PPh3)2] (1) and [Pt(η2‐o‐Me2TTF)(PPh3)2] (2), respectively. An X‐ray crystallographic study performed on 2 confirmed, that TTFs act as a π acidic ligand. NMR studies revealed the existence, in solution, of an equilibrium between free and complexed TTF. Dilithiation of o‐Me2TTF and subsequent silylation with ClSiMe2H afforded 3,4‐dimethyl‐3′,4′‐(dimethylsilyl)tetrathiafulvalene (3), which has been structurally characterized. 3 reacts by oxidative addition across [Pt(η2‐C2H4)(PPh3)2] to give [Pt{η2‐o‐(SiMe2)2TTFMe2}(PPh3)2] (4), in which the TTF ligand is covalently ligated to platinum via SiMe2 bridges. The redox properties of 3 and 4 have been investigated by cyclic voltammetry. Strong cathodic shifts of the two redox processes were observed for 4, implying the TTF core. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Crystal Structure and Excited Optical Nonlinearity of a 1D Polymeric [W2O2S6Cu4(NCMe)4]n Cluster
Authors: Zheng Hegen , Zhou Jianliang , Lappert Michael F. , Song Yinglin , Li Yizhi , Xin Xinquan
Published: May 2004

The self‐assembly reaction of (NH4)2(WOS3) with CuBr in the presence of PCy3 (PCy3 = tricyclohexylphosphane) in MeCN gives rise to a novel 1D polymeric compound [W2O2S6Cu4(NCMe)4]n (1) with solvent MeCN coordinated to the copper atom. This situation is unprecedented in the W(Mo)/Cu/S system. The excited state absorption and refraction of 1 in CH3CN solution were studied by using the Z‐scan technique with laser pulses of 40 ps pulse‐width at a wavelength of 532 nm. The compound possesses an optical self‐focusing performance. The positive nonlinear refraction is attributed to population transitions between singlet states. Compound 1 displays a strong excited‐state absorption, which induces an asymmetry between the peak and valley. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Crystal Structure and Properties of Ba11FeTi27O66.5
Authors: Vanderah Terrell A. , Siegrist Theo , Roth Robert S. , Ramirez Arthur P. , Geyer Richard G.
Published: May 2004

The crystal structure of Ba11FeTi27O66.5 was determined using single‐crystal and powder X‐ray diffraction methods. This phase crystallizes in the monoclinic space group C2/m (No. 12) (a = 23.324(1) Å, b = 11.388(1) Å, c = 9.8499(3) Å, β = 90.104(3)°; Z = 2; ρcalcd. = 4.98 g/cm3), and exhibits a 10‐layer structure built from close‐packed [O,(Ba,O)] layers with a stacking sequence (cchhc)2. Octahedral sites are occupied by a mixture of Fe3+ and Ti4+, with some preferential ordering suggested by analysis of bond valence sums. The structure features vertex‐, edge‐, and face‐sharing of the [Ti(Fe)O6] octahedra. Indexed X‐ray powder diffraction data for a polycrystalline specimen are given. Ba11FeTi27O66.5 and the 8‐layer phase Ba4Fe2Ti10O27 are built from the same types of polyhedral layers, some of which feature vacant sites between two Ba ions, which substitute for three oxygens in a row. The single‐crystal results suggest that the basic structural formula of the phase is A11B28O66+x, with the value of x (and hence the Fe/Ti ratio) determined by partial occupancy of one of these vacant sites. Variation of this occupancy factor with synthesis temperature may account for apparent slight differences in the stoichiometry of this phase in polycrystalline and single‐crystal form. However, solid solution formation was not observed for polycrystalline specimens. A comparison of the crystal structure obtained for Ba11FeTi27O66.5 with that previously proposed for “Zr4+‐stabilized Ba2Ti5O12” indicates that the phase “Ba2Ti5O12” is actually a ternary compound which forms upon addition (either deliberately or inadvertently) of a trivalent ion such as Fe3+ or Al3+. The specimens Ba11Al2Ti26O66, Ba11Al2Ti24Sn2O66, and Ba11Al2Ti24Zr2O66 were also prepared and were found to form the A11B28O66+x‐type phase. Ba11FeTi27O66.5 exhibits paramagnetic behavior that deviates somewhat from the Curie−Weiss Law below 75 K. Application of this formalism to the 1/χ vs. T data above 75 K yields an effective moment consistent with the presence of high‐spin Fe3+ (S = 5/2), and a negative Weiss constant (about −25 K) indicating weak cooperative magnetic interactions that are overall antiferromagnetic. The relative permittivity and dielectric loss tangent of a sintered polycrystalline disk were measured at 5.33 GHz, yielding values (corrected for theoretical density) of 55 and 7.7(±0.3) × 10−4, respectively. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Film Polymerization − A New Route to the Synthesis of Insoluble Polyimides Containing Functional Nickel(II) Schiff Base Units in the Main Chain
Authors: Di Bella Santo , Consiglio Giuseppe , Leonardi Nicoletta , Failla Salvatore , Finocchiaro Paolo , Fragalà Ignazio
Published: May 2004

The synthesis and characterization of a new, amino‐derivatized functional bis(salicylaldiminato)NiII complex is reported. It is a useful and reactive precursor in the synthesis of polyimide thermosets. Thus, the first synthesis of a polyimide containing a nonlinear optical NiII Schiff base complex in the main chain is achieved by thermally controlled film polymerization. Polymerization was monitored on silicon substrates by FT‐IR spectroscopy. The polymer film possesses characteristics analogous to those of the insoluble polymer obtained by polymerization in solution, as evidenced by FT‐IR spectroscopy and TGA analysis. The present approach might represent a general strategy for achieving thin films of insoluble, functional polymers. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Palladacyclopentadiene Complexes with Mono‐ and Didentate Imidato Ligands: Synthesis, Hemilabile Behaviour and Catalytic Application in the Stille Reaction
Authors: Serrano José Luis , Fairlamb Ian J. S. , Sánchez Gregorio , García Luis , Pérez José , Vives Jorge , López Gregorio , Crawforth Catherine M. , Taylor Richard J. K.
Published: May 2004

The binuclear hydroxo complex [NBu4]2[Pd2{C4(COOMe)4}2(μ‐OH)2] (1) has been prepared by addition of two equivalents of NBu4OH to polymeric [Pd{C4(COOMe)4}]n. Complex 1 has been successfully employed as a precursor to three novel binuclear imidate‐bridged complexes [NBu4]2[Pd2{C4(COOMe)4}2(μ‐imidate)2] [imidate = succinimidate (suc) 2, phthalimidate (pht) 3 or maleimidate (mal) 4] in which the imidate group displays a bidentate N,O‐coordination mode. The hemilabile behaviour of the imidate ligands has been investigated by reaction with a variety of P, N and S ligands, affording the corresponding mononuclear derivatives [NBu4][Pd{C4(COOMe)4}(imidate)L] [L = PPh3 (2a, 3a or 4a), P(p‐C6H4F)3 (2b, 3b or 4b), PBu3 (2c, 3c or 4c), py (2d, 3d or 4d), p‐MeC6H4NH2 (2e, 3e or 4e), tetrahydrothiophene (2f, 3f or 4f)] with terminal N‐bonded imidate ligands. The characterization of the new complexes involved spectroscopic methods (IR, FAB, 1H, 13C, 19F and 31P NMR) and X‐ray crystallographic analysis for 1, 4b and 4e. The mononuclear derivatives are shown to catalyse the Stille cross‐coupling of benzyl bromide 7 with ethyl Z‐vinylstannyl carboxylate (8) in high yields. Yields and reaction times are dependent on the presence and type of imidate ligand, which suggests an important role for it in the catalytic cycle. (© Wiley‐VCH Verlag GmbH and Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis and Characterisation of the First Three‐Dimensional Mixed‐Metal‐Center Inorganic‐Organic Hybrid Framework with N‐(Phosphonomethyl)iminodiacetate
Authors: Almeida Paz Filipe A. , Shi Fa‐Nian , Klinowski Jacek , Rocha João , Trindade Tito
Published: May 2004

Using crystal engineering concepts, the first three‐dimensional (3D) mixed‐metal‐centre inorganic‐organic hybrid frameworks incorporating N‐(phosphonomethyl)iminodiacetate (pmida4−) were synthesised under mild hydrothermal conditions (100 °C) and characterised structurally. The crystal structures, obtained by the displacement of the coordinated water molecules in [Co2V2O2(pmida)2(H2O)10]·2(H2O) (1) [P21/c monoclinic space group, Z = 2, a = 9.996(2) Å, b = 14.854(3) Å, c = 10.781(2) Å, β = 110.90(3)° and V = 1495.5(5) Å3] by the rod‐like bridging 4,4′‐bipyridine (4,4′‐bpy) ligand — [CdVO(pmida)(4,4′‐bpy)(H2O)2]·(4,4′‐bpy)0.5·H2O (2) and [CoVO(pmida)(4,4′‐bpy)(H2O)2]·(4,4′‐bpy)0.5 (3) — are isostructural and were also determined in the P21/c monoclinic space group (Z = 4) by single‐crystal X‐ray diffraction studies at low temperature (180 K): for 2, a = 9.1267(18) Å, b = 17.610(4) Å, c = 15.361(3) Å, β = 93.06(3)° and V = 2465.3(9) Å3; for 3, a = 8.7734(18) Å, b = 17.264(4) Å, c = 15.507(3) Å, β = 93.94(3)° and V = 2343.2(8) Å3. All the crystal structures contain centrosymmetric dimeric [V2O2(pmida)2]4− units connected to neighbouring M2+ cations (Cd2+ for 2, and Co2+ for 1 and 3) through the phosphonate group. In 2 and 3, extended two‐dimensional [MVO(pmida)(H2O)2]n layers are formed, with the 4,4′‐bpy molecules acting as pillars between adjacent layers, leading to porous 3D supramolecular structures, [MVO(pmida)(4,4′‐bpy)(H2O)2]∞, with a topology resembling that of the NbO net. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Coordination Chemistry of 1,3‐Bis(2‐pyridylimino)‐ and 1,3‐Bis(2‐thiazolylimino)soindole Copper Complexes: Investigation of Their Catalytic Behavior in Oxidation Reactions
Authors: Meder Markus B. , Gade Lutz H.
Published: May 2004

The copper complexes [Cu(4‐MeBPI)(OAc)] (4), [Cu(4‐Me‐10‐tBuBPI)(OAc)] (5) and [Cu(BTI)(OAc)] (6) [BPI = 1,3‐bis(2‐pyridylimino)isoindole, BTI = 1,3‐bis(2‐thiazolylimino)isoindole] were prepared by reaction of the protio ligands with copper(II) acetate. Compounds 4 and 6 were characterized by X‐ray diffraction, establishing distorted square‐planar coordination geometries of the copper ions. Two monoclinic modifications of 6 (6a and 6b) were found, both crystallizing in the space group P21/c, but possessing different cell parameters. In contrast to 6a, which is monomeric in the crystal, the second monoclinic modification 6b has a more complicated crystal structure, which is composed of both monomeric complex units such as those found in 6a and infinite chains of coordination polymers. The copper atoms in the polymeric chains of 6b display fivefold coordination and a ligand polyhedron that is an intermediate form between a trigonal‐bipyramidal and a square‐pyramidal geometry. The allylic peroxylation of cyclohexene with tBuOOH (70% aqueous solution) catalyzed by 4 and 6 (0.17 mol %) gave tert‐butylperoxy‐3‐cyclohexene with selectivities of 86% and 80% (based on cyclohexene) and turnover frequencies of 63 h−1 and 18 h−1, respectively. The peroxylation reaction is thought to proceed according to a Haber−Weiss radical chain mechanism. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)