bluuebunny/crossref_metadata_2025 huggingface dataset:
Early and late outcomes of combined and staged surgeries in patients with concomitant atherosclerotic lesions of the coronary and brachiocephalic arteries
Authors: Marchenko A. V. , Vronskiy A. S. , Myalyuk P. A. , Chebykin R. N. , Minasyan V. N. , Lazarkov P. V. , Sinelnikov Yu. S.
Published: January 2022

Objective. To study the early and late outcomes of surgical treatment of patients with concomitant atherosclerotic lesions of coronary and brachiocephalic arteries while choosing a treatment strategy based on the developed diff erentiated approach algorithm.Material and Methods. The study comprised 243 patients with combined atherosclerotic lesions of the coronary and carotid arteries examined during the period from 01.07.2014 to 01.01.2021. Patients underwent revascularization surgeries based on the algorithm for choosing the volume and stages of surgical intervention, which was previously developed in the Federal Center for Cardiovascular Surgery named after S.G. Sukhanov. A single-stage combined surgery of coronary artery bypass grafting (CABG) and carotid endarterectomy (CEE) was performed in 104 patients (42.8%); 139 patients (57.2%) received staged revascularization including 102 patients (73.4%) who received CABG as the fi rst step and 37 patients (26.6%) who received CEE as the fi rst step of surgery. The endpoints for both early and late results were death from all causes, stroke, transient ischemic attack (TIA), acute myocardial infarction (AMI), and combined endpoint that included all of the above. Average follow-up time was 41.1 ± 21.8 months.Results. No fatal outcomes were in any group during the early postoperative period. At the hospital stage, there were 5 cases (2.1%) of stroke, 1 case (0.4%) of TIA, and 3 cases (1.2%) of acute MI. Long-term results were evaluated in 225 patients (92.3%). The overall survival rate was 93.8%. There were 5 cases (2.4%) of MI, 11 cases (4.9%) of stroke, and 1 case (1.0%) of TIA. No signifi cant diff erences were observed in immediate and long-term endpoints between the groups of staged and combined interventions as compared to immediate (AMI: p = 0.680; TIA: p = 0.500; acute cerebrovascular events: p = 0.567; combined: p = 0.940) and long-term results (deaths: 0.860; AMI: p = 0.906; TIA: p = 0.528; acute cerebrovascular events: p = 0.378; combined: p = 0.669).Conclusion. Based on successful experience with treating the concomitant atherosclerotic lesions of the coronary and brachiocephalic arteries, the proposed algorithm allowed to perform safe procedures in both arterial basins and to achieve satisfactory results in in-hospital and long-term periods in the Federal Center for Cardiovascular Surgery named after S.G. Sukhanov (Perm).
The lineage of coronavirus SARS-CoV-2 of Russian origin: Genetic characteristics and correlations with clinical parameters and severity of coronavirus infection
Authors: Glotov O. S. , Chernov A. N. , Korobeynikov A. I. , Kalinin R. S. , Tsai V. V. , Anisenkova A. Yu. , Urazov S. P. , Lapidus A. L. , Mosenko S. V. , Shcherbak S. G.
Published: January 2022

The identification of new SARS-CoV-2 and human protein and gene targets, which may be markers of the severity and outcome of the disease, are extremely important during the COVID-19 pandemic. The goal of this study was to carry out genetic analysis of SARS-CoV-2 RNA samples to elucidate correlations of genetic parameters (SNPs) with clinical data and severity of COVID-19 infection.Material and Methods. The study included viral RNA samples isolated from 56 patients with COVID-19 infection who received treatment at the City Hospital No. 40 of St. Petersburg from 04/18/2020 to 04/18/2021. Patients underwent physical examination with the assessments of hemodynamic and respiratory parameters, clinical risk according to National Early Warning Score (NEWS), computed tomography (CT) of the chest, and laboratory studies including clinical blood analysis, assessment of ferritin, C-reactive protein (CRP), interleukin-6 (IL-6), lactate dehydrogenase (LDH), D-dimer, creatinine, and glucose levels. All patients tested positive for SARS-CoV-2 RNA by polymerase chain reaction (PCR). Single nucleotide polymorphisms (SNPs) in viral RNA were identified through the creation of cDNA libraries by targeted sequencing (MiSeq Illumina). Bioinformatic analysis of viral samples was performed using the viralrecon v2 pipeline with the further annotation via Pangolin and Nextlade. Sampled genomes were visualized using the Integrative Genomics Viewer (IGV) software. Statistical data processing (descriptive statistics and graphical analysis of data relationships from diff erent tables) was performed using a GraphPad device on the Prism 8.01 platform.Results. A comparative analysis of SNP frequencies in the virus genome in samples from deceased and discharged patients was carried out. The SNPs associated with risk of death (OR > 1), neutral SNPs (OR = 1), and protective SNPs (OR < 1) were identifi ed. Patient samples were infected with 14 lines of SARS-CoV-2, fi ve of which (B.1.1.129, B.1.1.407, B.1.1.373, B.1.1.397, and B.1.1.152) were of Russian origin. The SNPs in the samples infected with the strains of non-Russian origin were associated with an increased risk of mortality (OR = 2.267, 95% confi dence interval 0.1594-8.653) compared to the SNPs in the samples obtained from the group of patients infected with the strains of Russian origin. Positive correlations were identifi ed between the average SNP number, nonsynonymous SNPs, and S-protein SNPs with the degree of respiratory failure, total NEWS score, CT-based form of disease, duration of treatment with mechanical ventilation, disease outcome, levels of LDH, glucose, D-dimer, and ferritin, and RNA amount in the PCR test. S-protein SNPs negatively correlated with the leukocyte and neutrophil counts.
Co-expression analysis of placental genes in the search for key signaling pathways and biomarkers of the great obstetrical syndromes
Authors: Trifonova E. A. , Markov A. V. , Zarubin A. A. , Babovskaya A. A. , Kutsenko I. G. , Gabidulina T. V. , Izhoykina E. V. , Serebrova V. N. , Stepanov V. A.
Published: January 2022

Objective. To study the molecular mechanisms responsible for the development of diseases grouped within the great obstetrical syndromes (GOS) at the level of the transcriptome of human maternal placenta.Material and Methods. We gathered the results of genome-wide transcriptome studies of the human placental tissue using Gene Expression Omnibus (GEO) data repository for the following phenotypes: physiological pregnancy, preeclampsia (PE), premature birth, and intrauterine growth restriction (IUGR). Eleven data sets were selected and supplemented with our experimental data; a total of 481 samples of human placental tissue were included in the integrative analysis. Bioinformatic data processing and statistical analyses were performed in the R v3.6.1 software environment using the Bioconductor packages. The pooled dataset was used to search for common molecular targets for GOS via weighted gene co-expression network analysis (WGCNA). The functional annotation of genes and the resulting clusters was carried out with the DAVID database; protein-protein interaction network was built using the STRING software; and the hub genes for the network were identified using the MCC analysis with plugin cytoHubba in Cytoscape software 3.7.2.Results. We obtained a table of expression levels for 15,167 genes in 246 samples. Hierarchical clustering of this network allowed to find 55 modules of co-expressed genes in the group with PE, 109 modules in the group with PB, 75 modules in patients with IUGR, and 56 modules in the control group. The preservation analysis of co-expressed modules for the studied phenotypes suggested the presence of a common cluster comprising eight genes specific only for patients with PE and IUGR, as well as the module of 23 co-expressed genes typical only for patients with PB and IUGR. Protein-protein interaction network was built for these gene sets, and the SOD1, TXNRD1, and UBB genes were the central nodes in the network. Based on network topology evaluation with cytoHubba, six hub genes (rank ˂ 5) were identified as follows: SOD1, TKT, TXNRD1, GCLM, GOT1, and ACO1.Conclusion. The obtained results allowed to identify promising genetic markers for preeclampsia, intrauterine growth restriction, and miscarriage. Moreover, the study also made it possible to identify the most important overlapping molecular mechanisms of these diseases occurring in the placental tissue.
Analysis of differential expression of lipid metabolism genes in atherosclerotic plaques in patients with coronary atherosclerosis
Authors: Shakhtshneider E. V. , Ivanoshchuk D. E. , Ragino Yu. I. , Fishman V. S. , Polonskaya Ya. V. , Kashtanova E. V. , Chernyavsky A. M. , Murashov I. S. , Voevoda M. I.
Published: January 2022

Aim. The goal of the study was to analyze the differential expression of lipid metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis.Material and Methods. The study was performed on the specimens of atherosclerotic plaques in 45–65-year-old patients with coronary atherosclerosis with stable exertional angina functional class II-IV without acute coronary syndrome. Coronary atherosclerosis was verified by coronary angiography. Atherosclerotic plaque tissue was sampled intraoperatively when indicated. Whole-genome sequencing of ribonucleic acid (RNA) was performed using the TruSeq RNA Sample Preparation Kit (Illumina, USA).Results. We analyzed the differences in the expression of 12 genes including LDLR, APOB, PCSK9, LDLRAP1, LIPA, STAP1, ABCA1, APOA1, APOE, LPL, SCARB1, and SREBF2 depending on the type of atherosclerotic plaques. The expression level of APOE gene was eight times higher in unstable atherosclerotic plaques of dystrophic-necrotic type (p < 0.0001). The expression levels of LDLR and APOB genes were eight times higher in stable atherosclerotic plaques (p < 0.0001). We did not find differences in the expression levels of the ABCG5, ABCG8, APOC3, CETP, CLPS, CYP7A1, and PNPLA5 genes.Conclusion. The study showed the differences in the activity of individual metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis. Obtained data may become the basis for the development of test systems aimed at predicting the development of atherosclerotic process and its complications.
Correlation between the features of β1 and β3 integrin expression and lymphangitic metastatic spread in nonspecific invasive breast carcinoma based on tumor morphological heterogeneity
Authors: Krakhmal N. V. , Telegina N. S. , Zavyalova M. V. , Vtorushin S. V. , Krokhmal V. A. , Perelmuter V. M.
Published: January 2022

Objective. To study β1 and β3 integrin expression in nonspecific invasive breast carcinoma and to find the associations with parameters of tumor morphological heterogeneity and lymphatic dissemination.Material and Methods. Study group comprised 107 patients with breast cancer. Histological type of tumor corresponded to invasive carcinoma of a nonspecific type (invasive ductal carcinoma) in 100% of cases. Patients did not receive any preoperative treatment. In each case, we performed morphological examination of samples of primary tumor and axillary lymph nodes obtained at the surgical stage of treatment (radical mastectomy or sectoral resection of mammary gland with axillary lymphadenectomy). The parameters of β1 and β3 integrin expression in primary tumor tissue were assessed by immunohistochemistry.Results. The study demonstrated that an increase in the degree of malignancy of breast carcinoma was associated with a decrease in the incidence of positive expression of β1 integrin as well as with an increase in the incidence of positive expression of β3 integrin. Metastases in lymph nodes were significantly less frequently detected in the presence of positive expression of β1 integrin in the alveolar and solid structures compared with the cases of absent expression of the marker in similar structures (48%; χ2 = 3.5; p = 0.05 and 48%; χ2 = 4.8; p = 0.02, respectively). Lymphogenic metastasis were detected significantly more often in cases with positive expression of β3 integrin in discrete groups of cells compared with the cases where the expression of study marker in the described structures was absent (47 and 23%, respectively; χ2 = 5.1; p = 0.02).Conclusion. The results of work showed the presence of relationships between the morphological heterogeneity of the tumor and the parameters of β1 and β3 integrin expression in the parenchymal structures of the neoplasm. The study showed the association of described parameters with the frequency of lymphatic dissemination in patients with breast cancer. Obtained data expand and support previously known evidence and suggest the possibility of assessing the markers as potential prognostic factors predicting the course of cancer.
Search for associations between polymorphic variants of human acid chitinase gene and bronchial asthma in children of Novosibirsk
Authors: Makarova S. I. , Mitrofanov D. V. , Shintyapina A. B. , Komova E. G. , Zelenskaya V. V. , Kartseva T. V. , Kondyurina E. G. , Vavilin V. A.
Published: January 2022

High prevalence of bronchial asthma among the population (about 300 million people all over the world) provides rationale for the search for candidate genes of disease. Human acidic chitinase (CHIA (AMCase)), encoded by theCHIAgene, is involved in the degradation of chitin, a component of the fungal cell wall and arthropod exoskeleton, which, if present in food or house dust, is a provoking factor for the bronchial asthma (BA) development. Functionally significant mutations in theCHIAgene may apparently increase the risk of susceptibility to BA.Aim.The aim of the study was to assess the associations of single nucleotide polymorphisms (SNPs) rs12033184 and rs3806448 in theCHIAgene with bronchial asthma in children in Novosibirsk.Material and Methods. The study was organized as case-control. A total of 537 blood samples were used. SNPs were determined by real-time PCR. The associations of polymorphic variants with the disease were assessed by the odds ratio.Results.No associations of rs12033184 and rs3806448 with BA were found.Conclusion.The role of acidic chitinase gene in the development of BA in residents of Novosibirsk was found to be less significant than in the Indian population where it was previously shown to be associated with the disease.
Molecular genetic study of clinical and cognitive features of schizophrenia: No associations with genes SOD2, GSTO1, NQO1
Authors: Poltavskaya E. G. , Fedorenko O. Yu. , Kornetova E. G. , Ivanova S. A.
Published: January 2022

The main features of schizophrenia are characterized by three domains of symptoms, including positive symptoms, negative symptoms, and cognitive defi cits, the overlap of which forms a polymorphism of clinical manifestations. Previous molecular genetic studies have found signifi cant genetic overlaps between the cognitive abilities and the risk of schizophrenia developing. Recent evidence suggests that oxidative stress may play an important role in the pathophysiology of schizophrenia.Aim. The aim of the study was to investigate the associations of polymorphisms of genes encoding the antioxidant enzymes SOD2, GSTO1, and NQO1 with clinical polymorphism of schizophrenia and the severity of cognitive deficit.Material and Methods. A comprehensive examination of 457 patients with a diagnosis of schizophrenia was carried out. Out of the total group of examined patients, cognitive functions were assessed using the BACS scale in 150 schizophrenic patients. The control group comprised 135 healthy individuals with age and gender corresponding to patient group. Their cognitive function was assessed. Genotyping of SOD2 (rs4880), GSTO1 (rs4925), and NQO1 (rs1800566) was done by realtime PCR.Results. When analyzing the distribution of genotypes and alleles of polymorphic variants of genes encoding the antioxidant enzymes SOD2, GSTO1, and NQO1, no associations between the studied loci and schizophrenia in the Russian population of the Siberian region were revealed. Also, no associations were found with clinical polymorphism of disease (disease course type, leading symptoms (positive or negative), and age of disease onset). The cognitive abilities of schizophrenic patients and healthy individuals were diff erent as expected, but no associations with genetic characteristics were found.Conclusion. In this work, we obtained negative results in regard to associations of polymorphic variants of genes encoding the antioxidant enzymes SOD2 (rs4880), GSTO1 (rs4925), and NQO1 (rs1800566) with the development of schizophrenia in the Russian population in the Siberian region, as well as with the severity of cognitive defi cit. The genetic profi le for the studied loci did not aff ect the clinical manifestations of disease in the examined sample.
Perspectiva temporal: Una revisión sistematizada de su relación empírica con factores socioeconómicos y psicológicos
Authors: Luque Berkowitz Jorge Iván , Laborín Álvarez Jesús Francisco
Published: January 2022

Existe un creciente interés por el constructo perspectiva temporal (PT), el cual describe la influencia de marcos temporales en la cognición y el comportamiento. Se ha planteado que la PT se relaciona con el estatus socioeconómico. Donde una orientación al futuro influye en el manejo de finanzas personales, mayores logros educativos y mejor cuidado de la salud; no obstante, participantes bajo esta orientación suelen reportar bajos niveles de felicidad y satisfacción. En contraste, la orientación al presente se vincula con ingresos bajos, menor nivel educativo y cuidado deficiente de la salud, pero mayor felicidad y satisfacción. El objetivo del artículo es mostrar evidencia científica, mediante una revisión sistematizada, acerca de la relación entre PT y factores socioeconómicos y psicológicos, durante el periodo 1999 – 2020. Con ello se busca analizar el papel que juega la PT para el funcionamiento humano. Los resultados muestran una alta producción en el número de publicaciones. Finalmente, se discuten los alcances teóricos y metodológicos.
Evolución del gasto público del sector educativo de México
Authors: Contreras López Abigail , López Garrido Lauren Patricia , Jiménez Rico Artermio
Published: January 2022

Los recursos destinados al sector educativo son una inversión para México, porque gracias a ello se impulsa el desarrollo del país. En el presente artículo se mide la evolución del Gasto Nacional Educativo (GNE) en el sector educativo en México tomando como punto de comparación el porcentaje del Producto Interno Bruto que se destina a este sector y realizando la comparativa entre los países latinoamericanos y México, para ello, se analiza la información estadística de carácter público obtenida de plataformas de instituciones tales como, el Instituto Nacional de Educación Educativa (INEE), el Centro de Investigación Económica y Presupuestaria (CIEP), la Organización para la Cooperación y el Desarrollo Económicos (OCDE), la Secretaría de Educación Pública (SEP). Los resultados obtenidos indican un aumento monetario significativo en el gasto ejercido en los últimos años en materia de educación.
Efecto de la función psicológica en el bienestar subjetivo de los emprendedores mexicanos
Authors: González Peña Anais Estefanía , Sánchez Tovar Yesenia , Mellado Ibarra César Iván
Published: January 2022

Hoy en día la literatura sobre el emprendimiento ha transitado hacia los resultados que provoca no sólo a nivel económico en el individuo y su territorio, sino también en el bienestar de los emprendedores. El objetivo de este artículo es determinar el impacto de la percepción del funcionamiento personal y social en el bienestar subjetivo de los emprendedores mexicanos. Para la consecución de dicho propósito se plantea una investigación cuantitativa utilizando los datos proporcionados por la encuesta de Bienestar de INEGI (2020). La población estudiada está conformada por emprendedores mayores de edad en México alcanzando una muestra representativa de 480 emprendedores. A través de un análisis factorial y una regresión lineal múltiple se pudo contrastar que el funcionamiento personal y el funcionamiento social de los emprendedores afecta el bienestar subjetivo percibido, lo que permite un aporte a la literatura de la creación de empresas con la finalidad de promover el desarrollo económico del país.
RSE y ODS como herramientas del crecimiento en PyMEs: un estudio comparativo
Authors: Sainz Barjas Ma. Teresa de la Luz , Chiñas Valencia Juan José , Aguirre Alemán María Guadalupe
Published: January 2022

El crecimiento empresarial es detonante para el desarrollo de los países, las empresas en la actualidad se han alineado a los ODS y la RSE como herramientas que potencializan su capacidad hacia generar dicho crecimiento. En el presente estudio se tiene como objetivo general comparar el nivel en que las PyMEs comerciales y de servicios del sur del estado Veracruz que realizan acciones alineadas a los ODS y RSE, está contribuyendo al crecimiento empresarial. La investigación se posiciona desde el paradigma empírico-analítico, con un enfoque cuantitativo y transversal. Para la recolección de la información se diseñó una encuesta basada en la revisión de la literatura y la cual fue validada, además se recurrió a un muestreo no probabilístico a conveniencia, obteniendo dos muestras independientes: 75 comerciales y 34 de servicios, los informantes fueron gerentes o dueños. El método de análisis utilizado fue el análisis descriptivo y se recurrió a la prueba de hipótesis a través de la técnica de U de Mann-Whitney. Los resultados demuestran que existen diferencias entre ambas muestras, obteniendo un nivel tanto en comerciales y de servicios medio-alto, no obstante, se observaron diferencias, la prueba de hipótesis denota que se apoya la hipótesis de investigación, en donde se apoya que el nivel en el crecimiento entre ambas muestras es diferente. En definitiva, las acciones que adopta las PyMEs sobre ODS y RSE si están impactando en el crecimiento empresarial en el mercado donde se desarrollan.
Determinantes que influyen en el precio de renta de departamentos en Monterrey Nuevo León
Authors: Cruz Lara Carlos
Published: January 2022

El objetivo de este artículo es indagar sobre los determinantes de los precios mensuales de renta en departamentos que se localizan en Monterrey en los años 2019 y 2020 Nuevo León. La hipótesis es que las personas jóvenes son quienes están en constante búsqueda de departamentos, sobre todo las mujeres ya que buscan estar más cerca de su escuela o de su trabajo. Los datos fueron recabados del periódico “El Norte” ya que es un periódico muy La muestra se obtuvo por un mecanismo  no probabilístico. Además se utiliza un modelo de precios hedónicos como lo plantea Rosen (1974) para saber cuáles son los aspectos y características que influyen en la toma de decisiones para la búsqueda  de departamento. Los principales hallazgos fueron que los departamentos con mayor demanda son los que tienen tres habitaciones, un baño y medio, céntrico y lo más importante que el costo este dentro del rango de los precios del mercado. Finalmente esta investigación se divide en secciones: la primera se refiere a la introducción, la segunda al marco teórico, la tercera al método, la cuarta a los resultados y la quinta a la conclusión.
Diseño y validación de un instrumento que permita identificar los factores que influyen en la productividad laboral
Authors: Meraz Sepúlveda Joel , González Espinoza Mayda , Muñoz del Real Gloria
Published: January 2022

Uno de los objetivos de toda organización sea pública o privada es maximizar la productividad de sus trabajadores para poder ser más eficientes y eficaces al brindar los productos y servicios que ofrecen. En este sentido uno de los grandes problemas de los sistemas de justicia es la falta de presupuesto para hacerle frente a las necesidades de mejora en las diversas áreas de la organización. Es así como el objetivo de este trabajo se centró en diseñar y validar un instrumento que permitiera detectar aquellos factores o variables que influyen en la productividad laboral de los notificadores del Centro de Justicia Penal unidad Río Nuevo, en la ciudad de Mexicali, Baja California; y así, poder enfocar el recurso económico en un área que provoque un mayor impacto. El instrumento diseñado consistió en un cuestionario de 69 ítems que se validó mediante diversas pruebas estadísticas: entre ellas el alfa de Cronbach, KMO, esfericidad de Bartlett y comunalidades. Se demostró que de entre las variables analizadas existe mayor correlación entre la productividad laboral y capacitación, quedando en evidencia que existe asociación entre las variables analizadas. Es así, que el instrumento validado podrá ser de utilidad para analizar la productividad laboral en diversos campos de estudio debido a su construcción de carácter general.
Estudio bibliométrico de la relación del Cambio Organizacional con el Aprendizaje Organizacional
Authors: Bellon Álvarez Luis Alberto , López Cerpa Francisco Javier , Islas Villanueva Margarita Isabel
Published: January 2022

Para este artículo se realizó un análisis bibliométrico de la situación actual del estudio del impacto del aprendizaje organizacional en un proceso de cambio organizacional. El objetivo de esta investigación fue hacer un estudio que refleje las tendencias de investigación sobre la relación entre el cambio organizacional y el aprendizaje organizacional. Por lo que se efectuó una búsqueda de las variables entre títulos, resúmenes, así como palabras clave, de los documentos científicos obtenidos del repositorio académico Web of Science. Llevando a cabo la búsqueda de las publicaciones a través de las palabras claves elegidas, que fueron: “cambio organizacional” y “aprendizaje organizacional”. Dichas palabras determinaron el área de conocimiento, así como el área de acción del tema objeto de investigación. Dando como resultado de esta búsqueda un total de 217 documentos científicos. Los datos obtenidos fueron procesados con el programa VOSviewer, mediante el método de recuento de coocurrencias, en función de las palabras claves indexadas. Dando como resultado cinco clústeres que muestran las distintas perspectivas de cómo se ha abordado este tema. Este trabajo proporciona un panorama general del tema estudiado y puede ser útil para empresarios, investigadores y estudiosos del tema. Se sugiere efectuar una revisión más profunda de la literatura sobre el tema y de las investigaciones realizadas, para así poder identificar las herramientas y áreas de aplicación que hay actualmente. Se puede concluir que los resultados de la investigación muestran que hay un aumento en las aportaciones y publicaciones del tema, así como en su frecuencia de publicación.
Bienestar laboral en docentes de una institución pública
Authors: De Jesús Álvarez Jonathan Nahum , Santiago Bautista Margarita del Consuelo
Published: January 2022

Este trabajo presenta los resultados de una investigación dirigida en analizar los factores de bienestar laboral en los docentes la Facultad de Contaduría y Administración de la Universidad Veracruzana (UV), todo esto, desde su propia percepción. Esta investigación tiene un carácter analítico, además de tener un corte transversal. Para ello, se utilizó la técnica de encuesta, a través de un cuestionario al que se le denominó: Cuestionario de   Bienestar laboral, el cual está estructurado por cinco factores; la primera identifica el logro que el docente proporciona a sus metas y resultados; la segunda, evalúa el factor de reconocimiento que   los docentes perciben por parte de su jefe inmediato, el tercer factor mide la perspectiva de  su trabajo, es decir, si lo encuentra desafiante, innovador, creativo, entre otros; el cuarto factor es el de identificar su propia responsabilidad en el  trabajo y el último factor de promoción relacionado al cambio horizontal o vertical dentro de la organización. La hipótesis que se planteó fue la siguiente: Los factores del bienestar laboral presentes en los docentes de la facultad de contaduría y administración de la universidad veracruzana campus Coatzacoalcos es favorable, se encuestó a 59 docentes de FCA, en la información se observa que los factores son importantes en la percepción del bienestar laboral en el ejercicio de sus propias funciones. Por otra parte, las situaciones contractuales no representan variaciones significativas en su bienestar. Para finalizar, la característica género sí presentó diferencia significativa para el bienestar laboral.
Efecto de la proactividad y actitud del capital humano en el desempeño cívico
Authors: Bernal González Idolina , Pedraza Melo Norma Angélica , Flores Flores Adán Jacinto
Published: January 2022

Este estudio se realiza con la finalidad de analizar el efecto que los factores de proactividad y actitud, tiene sobre el desempeño cívico del personal adscrito a instituciones públicas localizadas en el estado de Tamaulipas, México. La investigación se aborda desde el enfoque cuantitativo, de alcance descriptivo-explicativo, con la participación de 269 trabajadores encuestados. Para el análisis de los datos se utiliza análisis factorial a fin de validar la estructura subyacente de los constructos estudiados, posteriormente se aplica modelo de ecuaciones estructurales. Como principales resultados se determina que los factores de proactividad y actitud explican positiva y significativamente el desempeño cívico del personal, siendo la proactividad la que mayor impacto manifiesta tener con la variable dependiente, lo cual aconseja una adecuada gestión del capital humano a fin de elevar su desempeño laboral y fortalecer sus conductas hacia la institución.
Recursos didácticos digitales que permiten mejorar la práctica preprofesional en el contexto de la emergencia sanitaria Covid-19
Authors: Ávila Larriva Mónica Priscila
Published: January 2022

La problemática del estudio se desarrolla a partir de la emergencia sanitaria Covid-19 modificando la modalidad de estudios universitarios, ésta cambia por una modalidad virtual obligando a realizar la práctica pre profesional (PPP) desde este contexto. El objetivo del estudio fue establecer recursos didácticos digitales que favorezcan la práctica PPP. La metodología del estudio es de tipo exploratorio, descriptivo, correlacional, no experimental de corte transeccional y explicativo mediante la aplicación de una encuesta a 19 estudiantes y dos tutores de la PPP. La hipótesis declara que los recursos didácticos que permiten mejorar la PPP en el contexto de la pandemia son: el portafolio digital, el juego-trabajo, la animación a la lectura mediante E-books y los bits de inteligencia en Web-álbumes como estrategias para el conocimiento. Los resultados fueron estadísticamente significativos, confirman la hipótesis de estudio para la ejecución de los recursos didácticos digitales en la PPP.
Factores que influyen en las MiPyMES en tiempos de Covid-19
Authors: Torres Garza Allen Ricardo , Carrera Sánchez María Margarita , Partida Puente Abel
Published: January 2022

El impacto social, económico y productivo que ha tenido el Covid-19, indudablemente será material de estudio durante años, el mundo se encuentra aún inmerso entre el primer brote y un rebrote. Con la llegada del Covid-19 se han generado grandes cambios sociales y económicos, las empresas se han visto obligadas a modificar sus modelos de negocio para mantenerse vigentes durante la presente contingencia sanitaria. El objetivo del presente trabajo de investigación tiene como finalidad describir los factores que influyen en las MiPyMES y sus efectos en estas. El análisis realizado se definió con base a un marco de referencia, técnica utilizada documental y bibliográfica, que permiten identificar los factores que se presentan con regularidad en tiempos de pandemia. Los resultados del presente estudio demuestran que, al implementar cambios tecnológicos, entornos colaborativos, innovaciones y nuevos modelos de negocio, influyen positivamente en las MiPyMES en tiempos de pandemia. En el presente trabajo se concluye que las investigaciones empíricas señalan que las variables de estudio han servido de apoyo para que las MiPyMES puedan mantenerse y no desaparezcan ante la contingencia sanitaria originada por el Covid-19.
ESG Impact on Financial Corporate performance and portfolio returns: evidence of Australia and Japan
Authors: Kazakakou Powaski Margarita Chrissanthi , Daza Ordoñez Carolina , Jáuregui Sánchez Laura
Published: January 2022

La inversión ambiental, social y de gobernanza ha experimentado un cambio radical; empresas e inversionistas se han centrado en el impacto de la divulgación de las prácticas y políticas relacionadas con el medio ambiente, la responsabilidad social y la gobernanza en sus estrategias operativas e inversiones. El propósito de este documento es demostrar el impacto que las políticas ESG tienen en la rentabilidad de las acciones de las empresas públicas en Australia y Japón. Se utilizan medidas contables y de mercado para determinar el impacto que tienen las prácticas ESG en los rendimientos de los índices bursátiles. Los datos anuales utilizados son de empresas del índice S & P / ASX de Australia y del índice Nikkei 225 de Japón, que cubren el período de 2005 a 2019. Se utilizó la regresión del modelo de efectos fijos para probar la relación significativa entre la rentabilidad de las acciones de las empresas y la puntuación ESG, la contabilidad y medidas basadas en el mercado. Se crearon carteras para analizar la relación riesgo / rentabilidad entre empresas con y sin ESG en todos los países. Los hallazgos indican resultados mixtos. Las carteras no ESG de Australia superan a las carteras S & P500 y ESG. La cartera de Japón tiene rendimientos positivos, pero está por debajo del índice de referencia. Las carteras de baja capitalización de mercado con y sin ESG superan a las carteras de mayor capitalización.
Analysis of existing technologies for processing oil sludge into polymer additives for asphalt concrete
Authors: Glum T.P. , Menshikov S.O. , Smirnov Yu.D.
Published: January 2022

The article deals with the known information about the main type of oil industry waste – oil sludge. Existing methods and technologies of oil sludge processing into polymer additives for asphalt concrete are presented and analyzed. The main problems and shortcomings of the methods of oil sludge processing considered in the study are revealed.
Metode SVM Untuk Klasifikasi Enam Tumbuhan Zingiberaceae Menggunakan Variabel Terpilih Hasil Algoritma Genetika
Authors: Oktaria Triyani , Syafitri Utami Dyah , Rafi Mohamad , Afendi Farit M
Published: January 2022

Ginger, red ginger, emprit ginger, elephant ginger, red galangal and white galangal are known to have similar shapes and uses, especially those that are packaged in powder form. In this study, UV-Vis spectrum 200nm-700nm were used as a source of data from chemical compound contain in those plants for classification of the six plants. In this research, the support vector machine (SVM) classification method was used to classify the six plants. Another goal of this study was to identify the wavelengths which give more information about the chemical compound of the plants. The preprocessing procedure was implemented by construction of a genetic algorithm. There were four parameters in the genetic algorithm were set namely population size, crossover probability, mutation, and generation probability. The mutation and the population size influenced significantly the results of SVM. The best result was given by probability of mutation was 10 and population size was 30. The SVM model was better than the SVM model without preprocessing procedure.
Ground Validation of GPM IMERG-F Precipitation Products with the Point Rain Gauge Records on the Extreme Rainfall Over a Mountainous Area of Sumatra Island
Authors: Ramadhan Ravidho , Marzuki Marzuki , Yusnaini Helmi , Ningsih Ayu Putri , Hashiguchi Hiroyuki , Shimomai Toyoshi , Vonnisa Mutya , Ulfah Syarifatul , Suryanto Wiwit , Sholihun Sholihun
Published: January 2022

Accurate satellite precipitation estimates over areas of complex topography are still challenging, while such accuracy is of importance to the adoption of satellite data for hydrological applications. This study evaluated the ability of Integrated Multi-satellitE Retrievals for GPM -Final (IMERG) V06 product to observe the extreme rainfall over a mountainous area of Sumatra Island. Fifteen years of optical rain gauge (ORG) observation at Kototabang, West Sumatra, Indonesia (100.32°E, 0.20°S, 865 m above sea level), were used as reference surface measurement. The performance of IMERG-F was evaluated using 13 extreme rain indexes formulated by the Expert Team on Climate Change Detection and Indices (ETCCDI). The IMERG-F overestimated the values of all precipitation amount-based indices (PRCPTOT, R85P, R95P, and R99P), three precipitation frequency-based indices (R1mm, R10mm, R20mm), one precipitation duration-based indices (CWD), and one precipitation intensity-based indices (RX5day). Furthermore, the IMERG-F underestimated the values of precipitation frequency-based indices (R50mm), one precipitation duration-based indices (CDD), one precipitation intensity-based indices (SDII). In terms of correlation, only five indexes have a correlation coefficient (R) > 0.5, consistent with Kling–Gupta Efficiency (KGE) value. These results confirm the need to improve the accuracy of the IMERG-F data in mountainous areas.
O departamento do patrimônio histórico de São Paulo na administração de Luiza Erundina: questões conceituais
Authors: Retroz Sergio Ricardo
Published: January 2022

O Departamento do Patrimônio Histórico (DPH), órgão do município de São Paulo ligado à Secretaria Municipal de Cultura (SMC), desenvolveu sua atividade de preservação patrimonial parcialmente ligada ao conceito de patrimônio ambiental urbano. Durante a administração municipal de Luiza Erundina, a SMC, confiada à Marilena Chauí, passou a trabalhar com o conceito de cidadania cultural. O DPH, naqueles anos sob a direção de Déa Ribeiro Fenelon, passou a conciliar o conceito de patrimônio ambiental urbano com aquele de cidadania cultural, o que proporcionou um campo fértil de trabalho e de desenvolvimento conceitual do patrimônio.
CEDEM em Pesquisas
Authors: Valle Maria Ribeiro do
Published: January 2022

O Dossiê que ora apresentamos busca demonstrar a importância do CEDEM (Centro de Documentação e Memória) da UNESP, que vem resistindo a essa conjuntura repressiva, sendo um guardião da memória. Seus eixos fundamentais são a memória da Universidade, particularmente a da UNESP, e a dos movimentos sociais e políticos.
MICROBIOLOGICAL AND TREATMENT STUDIES OF OVINE FOOTROT INFECTION IN MOSUL AREA
Authors: RHAYMAH M.SH. , SAWA M. L. , YOUSIF Y.A.
Published: January 2022

It emerges from bacteriological study that it is possible to isolate many bacterial types and yeasts from the lesions of footrot infection in sheep. Anaerobic cultivation came out with the isolation of Spherophorus spp. (24%), Bacteroides spp. (60%), Corynebacterium spp. (64%), Enterobacteracae (76%), Streptococcus spp. (76%), Staphylococcus spp. (36%), Clostridum sordellii (46%) and Irichosporon cutaneum (4%). 

On the other hand aerobic cultivation rendered the isolation of Corynebacterium spp. (100%), Entrobacteracae (100%), Staphylococcus spp. (15%), Penicillium spp., Aspergillus fumigatus and Trichosporon cutaneum. 

Five different drug combinations were studied for their efficacy in the treatment of ovine footrot. Their healing rates were as follows : oxytetracycline (59%), oxytetracyclin with formaline (70.9%), Procaine penicillin and streptomycin (72.5%), Procaine penicillin and streptomycin with formaline dipping (80.76%), Formaline alone (63.8%). All kinds of treatment indicated statistically significant differences to exit between the treated (experimental) and untreated (control) groups
Some Teratogenic Outcomes in Rats Exposed to Zinc Chloride Pre and Post Pregnancy
Authors: Zaher Abdul-Rahman , AL-Rekabi Falah M , Akram Hatif Saad
Published: January 2022

The aim of present study was to evaluate the possibility of teratogenicity in rats when exposed to zinc chloride (ZnCl2) pre and post pregnancy. To achieve this goal, a total of 40 mature Albino Wistar female rats were divided equally into four groups as follows: T1, dosed 0.7 mg/day ZnCl2 for two months before mating and till to the day 5th of pregnancy, the females of this group were mated with males dosed 0.7 mg/day ZnCl2 for two weeks before mating; T2, dosed 0.7 mg/day ZnCl2 for two months before mating and till to the day 16th of pregnancy and then were mated with control males (not exposed to any level of ZnCl2); T3, dosed 0.7mg/day ZnCl2 for two months before mating and till the end of pregnancy and were mated with control males; Control, dosed with water free from ZnCl2 along the period of experiment and were mated with control males. At the end of each pregnancy phase, results revealed that alpha fetoprotein serum levels were significantly (P<0.05) higher in all treatment groups compared to the control group, and the most prominent increase was observed in the T3 group. All treatment groups showed a significant (P<0.05) decrease in gestation, viability, and lactation indices when compared to the control group, with the T3 group showing the most significant decrease. Additionally, on days 1, 4, 7, 14, and 21 of lactation period, there was a significant (P<0.05) decrease in mean pup body weights in treated groups compared to the control group, with T3 group having the most prominent body weight decrease. The findings of this study revealed that ZnCl2 at a daily dose of 0.7 mg may cause teratogenic defects in rats at various stages of pregnancy, particularly at the third stage. As high-risk groups, pregnant women and children should use Zn supplementation carefully, whether as a food additive or for self-medication. Simultaneously, evaluating effect of low-dose Zn supplementation over a longer duration is required.
Collateral beauty in the wind of truth: reclaiming a new sense of reality
Authors: Casadei Rita
Published: January 2022

It is beautiful to be able to have the opportunity to allow oneself a doubt on the unquestionability of one's mental habits; it is beautiful to be able to renew one's energy to relate to the world in a way not bent by the banality of convenience and calculation. It is beautiful to realise that one feels the need for beauty as an inspirational motive for one's thinking, feeling and acting, and as a resource towards a new education. The serious pandemic crisis has probably accelerated a necessary but demanding process that takes time to accomplish: that of becoming aware of a reality based on the principle of interconnection and interdependence – of the person with all his/her dimensions, with each other, with the Cosmos. I believe that this new perception of reality – as the result of an experience – can mark a new step for the discourse and pedagogical practice so as to devote itself to a new form of beauty in the search for a ἀλήθεια (aletheia) truth to be configured as a desire for unveiling and deep understanding of the sense of reality, to be nourished in a revitalised interdisciplinarity, with a sense of wonder and amazement for every aspect of life. Care, responsibility and commitment, if animated by joy and love, can only aspire to excellence, giving the person the opportunity to fully realise his or her dignity and humanity.
New Paradigm in Nutrition Practice – Initial Findings From Ntuitive Software
Authors: Karkera Priya , Singal Arbinder , Sawant Jayesh , Gupta Shailesh
Published: January 2022

Objective:Nutrition practice in India has generally been confined to pen and paper with little use of algorithms and technology. Nutritionists in practice find it difficult to go beyond macronutrient analysis for dietary intake or diet plans. Since nutrition practice requires lot of data processing, we decided to develop software to aid in these calculations and to empower nutritionist with technology enabled scientific practice using software.Method: Ntuitive software was developed by a team of nutrition experts and technologists over a period of 18 months. Data for nutrient values was sources from IFCT 2017 [6], RDA’s were taken from ICMR guidelines and growth charts from IAP publications [7]. Design and coding of the software was done inhouse. Ntuitive database has over 8500 recipes and packed foods and has most of the national and international cuisine items. The software module enables client / patient management, detailed profiling, recording anthropometric data and plotting on WHO and IAP growth charts, recording food allergies and medical condition. The dietary recall be it one day, three day or seven day can be easily recorded and analysis of nutrients can be obtained for the same. The software is hosted on Amazon Web Server and applied as SAAS platform for practice.Result:800 children and adults underwent analysis and consultation using Ntuitive software. All 189 micronutrients could be calculated using the software and deficiency or excess quantified when compared with RDA.Conclusion: Nutrition practice can be made easy and technology enabled keeping in mind scientific standards. This helps in data collection not just in macro nutrients, but also in micronutrients.
SARS-CoV-2-the Unforeseen Peril of David Winning Against Goliath: the Immune Giant Collapsing Under Its Own Rampaging Cytokine Storm
Authors: Sofra Xanya
Published: January 2022

We examined SARS-CoV-2 (Covid-19) available treatments and prophylactic methods that included interventions associated with inhibiting the “type II transmembrane serine protease” (TMPRSS2) to limit the fusion between the Covid-19 Spike proteins and ACE2 receptors, or newly developed therapeutics like Remdesivir that interferes with the viral RNA replication. We explored the dilemma of ACE2 receptors that have a protective function against high blood pressure associated disorders, yet,they serve as the viral points of entry, elevating the probability of infection. Human tissues’ analysis reveals a higher ACE2 expression in adipose tissue, placing obesity-related conditions in the eye of the pandemic storm. It primarily exposes males due to the surge of ACE2 receptors in the testes along with other tissues. Males manifest a relatively higher positive ACE2 orrelations with certain immune cells in the lungs,thyroid, adrenals, liver and colon, while females evidence higher ACE2 correlations with immune cells in the heart. The remaining tissues’ ACE2/immunity expressions are equivalent in both sexes, indicating that despite its preference for males, the threat of Covid-19 can easily target females.Recent reports indicate that Covid-19 is empowered by hindering the critical process of viral recognition during the adaptive immune response leading to the “cytokine storm”, the aggravated immune response that indiscriminately perseveres, rampaging the host’s vital organs. Sedentary lifestyle, age-related hormonal imbalance, and adiposity induced inflammation predispose the body to the immune collapse following Covid-19 invasion, spotlighting the detrimental aftermath of metabolic dysfunction,and excess food consumption provoked by elevated cortisol and dysregulated appetite hormones. ACE 2 expression is suppressed in the skeletal muscle, rendering fitness and weight management an effective Covid-19 preventive intervention, along with social distancing, hygiene, and facial coverings. Physical activity, or exercise alternative methods have recently demonstrated statistically significant reductions of the inflammatory marker C-Reactive Protein (CRP), triglycerides, visceral fat, cortisol and the orexigenic hormone ghrelin, juxtaposed by optimal increases of IGF-1, skeletal muscle mass, Free T3, HDL, and the anorexic hormone leptin.