Hygienic assessment of the probiotic Bioseven influence on the natural resistance of rabbits pre-clinical researches
Authors: Dyuba A. , Lyasota V. 
Published: February 2024

Rabbit farming plays an important role in the increase of livestock products, one of the precocious branches of small animal husbandry. From a rabbit and its offspring, more than 100 kg of meat can be obtained per year. The body of rabbits, as well as other agricultural and rural animals. animals, during life is under the influence of abiotic and biotic factors that cause growth depression, changes in the morphological composition of blood, and immunological indicators. The use of biologically active drugs that increase immunological reactivity, stimulating growth, development and resistance deserve attention. The use of probiotic preparations of young animals in the early stages of breeding normalizes the microflora of the gastrointestinal tract, stimulates the synthesis of immunoglobulin IgA, increases its natural resistance, and activates homeostasis. The aim of the work was to carry out a hygienic assessment of the effect of the probiotic Bioseven on the natural resistance of the rabbit's body. The following methods of observation were used to obtain scientific information: biological, hematological, biochemical studies, statistical. The research was conducted on rabbits of the gray giant breed of both sexes. Healthy animals with the appropriate body weight were used in the experiments. Fluctuations in body weight in the respective groups did not exceed ±10.0%. Animals were kept in groups in cages in compliance with sanitary and hygienic requirements. The use of the new domestic biologically active drug (probiotic) Bioseven as a means of preventive action is substantiated in the research paper. The drug has been proven to have a positive effect on the morphological, biochemical and immunological parameters of the blood of animals, increase the natural resistance and growth intensity of rabbits. During morphological studies, it was established that the level of endogenous intoxication of the body of rabbits of experimental groups and controls during the observation period remained stable and amounted to 17.95-18.33% (experimental) and 18.42±0.55 in control, which indicates the absence of a suppressor effects of the probiotic bioseven on the antioxidant properties of the rabbit body in doses: 0.5-5.0 g/head. The economic efficiency of the use of Bioseven consists of: a reduction in the morbidity of animals, an increase in their preservation, an average daily increase in body weight, and therefore an additional increase of 0.300-1.200 kg (depending on the dose), a reduction in the cost of obtaining a unit of production (by 0.5 %) and a decrease in the cost of livestock products per head during the period of the experiment by 5.0–15.0 UAH. Thus, the hygienic evaluation of the effect of the probiotic Bioseven on the natural resistance of the rabbit's body indicates the absence of a suppressive effect of the drug on the metabolic processes of the body of laboratory animals.
Key words: rabbit breeding, suppressive effect, probiotic, toxicological characteristics, biochemical, ecologically harmless, complete, food products, of animal origin, food safety, consumer.