bluuebunny/crossref_metadata_2025 huggingface dataset:
Visibility Graph Analysis of Heartbeat Time Series: Comparison of Young vs. Old, Healthy vs. Diseased, Rest vs. Exercise, and Sedentary vs. Active
Authors: Muñoz-Diosdado Alejandro , Solís-Montufar Éric E. , Zamora-Justo José A.
Published: April 2023

Using the visibility graph algorithm (VGA), a complex network can be associated with a time series, such that the properties of the time series can be obtained by studying those of the network. Any value of the time series becomes a node of the network, and the number of other nodes that it is connected to can be quantified. The degree of connectivity of a node is positively correlated with its magnitude. The slope of the regression line is denoted by k-M, and, in this work, this parameter was calculated for the cardiac interbeat time series of different contrasting groups, namely: young vs. elderly; healthy subjects vs. patients with congestive heart failure (CHF); young subjects and adults at rest vs. exercising young subjects and adults; and, finally, sedentary young subjects and adults vs. active young subjects and adults. In addition, other network parameters, including the average degree and the average path length, of these time series networks were also analyzed. Significant differences were observed in the k-M parameter, average degree, and average path length for all analyzed groups. This methodology based on the analysis of the three mentioned parameters of complex networks has the advantage that such parameters are very easy to calculate, and it is useful to classify heartbeat time series of subjects with CHF vs. healthy subjects, and also for young vs. elderly subjects and sedentary vs. active subjects.
Evaluation of Water and Carbon Estimation Models in the Caatinga Biome Based on Remote Sensing
Authors: de Oliveira Michele L. , dos Santos Carlos Antonio Costa , Santos Francineide Amorim Costa , de Oliveira Gabriel , Santos Celso Augusto Guimarães , Bezerra Ulisses Alencar , de B. L. Cunha John Elton , da Silva Richarde Marques
Published: April 2023

The study of energy, water, and carbon exchanges between ecosystems and the atmosphere is important in understanding the role of vegetation in regional microclimates. However, they are still relatively scarce when it comes to Caatinga vegetation. This study aims to identify differences in the dynamics of critical environmental variables such as net radiation (Rn), evapotranspiration (ET), and carbon fluxes (gross primary production, GPP) in contrasting recovered Caatinga (dense Caatinga, DC) and degraded Caatinga (sparse Caatinga, SC) in the state of Paraíba, northeastern Brazil. Estimates were performed using the Surface Energy Balance Algorithm for Land (SEBAL), and comparisons between estimated and measured data were conducted based on the coefficient of determination (R2). The fluxes were measured using the Eddy Covariance (EC) method for comparison with the same variables derived from Moderate Resolution Imaging Spectroradiometer (MODIS) data aboard the Terra satellite. The estimates showed higher Rn values for the DC, indicating that this area should have greater energy availability for physical, biological, and chemical processes. The R2 between daily Rn estimates and observations was 0.93. The ET estimated using the SEBAL showed higher differences in relation to the observed values; however, it presented better spatial discrimination of the surface features. The MOD16A2 algorithm, however, presented ET values closer to the observed data and agreed with the seasonality of the Enhanced Vegetation Index (EVI). The DC generally showed higher ET values than the SC, while the MODIS data (GPP MOD17A2H) presented a temporal behavior closer to the observations. The difference between the two areas was more evident in the rainy season. The R2 values between GPP and GPP MOD17A2H were 0.76 and 0.65 for DC and SC, respectively. In addition, the R2 values for GPP Observed and GPP modeled were lower, i.e., 0.28 and 0.12 for the DC and SC, respectively. The capture of CO2 is more evident for the DC considering the whole year, with the SC showing a notable increase in CO2 absorption only in the rainy season. The GPP estimated from the MOD17A2H showed a predominant underestimation but evidenced the effects of land use and land cover changes over the two areas for all seasons.
Effects of Trace Elements on Traits and Functional Active Compounds of Camellia oleifera in Nutrient-Poor Forests
Authors: Dai Qiuyue , Deng Zheng , Pan Lan , Nie Lang , Yang Yunyuan , Huang Yongfang , Huang Jiuxiang
Published: April 2023

Camellia oleifera is a major woody oilseed species in China, but it is typically cultivated in nutrient-poor soils and may be affected by various trace elements. This study examined how spraying selenium, boron, and zinc trace elements affected the traits and functional active compounds of C. oleifera under nutrient deficiency. The results revealed significant variations in the effects of different trace element combinations on C. oleifera. Optimal concentrations of zinc and selenium are critical for promoting the growth and development of C. oleifera fruit. The transverse diameter of the fruit, the single fruit weight, the number of seeds per fruit, the single fresh seed weight, the oil content in the fruit, and the oil yield per plant of other treatments can be increased by up to 3.07%, 10.57%, 23.66%, 30.23%, 7.94%, and 21.95%, respectively, at most, compared to the control group. Diluting zinc from 1000 to 1500 times and maintaining a selenium concentration from 100 to 200 mg/L has been found to be beneficial for fruit growth. While low concentrations of selenium may promote an increase in fruit transverse diameter, high concentrations of selenium, along with high dilutions of zinc, can have the opposite effect, leading to a reduction in fruit diameter. However, a high concentration of selenium can positively impact the number of seeds per fruit. The most effective combination was found to be a selenium concentration of 0 mg/L, a boron concentration of 4 mg/L, and a zinc dilution of 1500. Interestingly, lower concentrations of selenium and boron, as well as lower dilutions of zinc, were found to increase the oil yield per plant. This suggests that a careful balance of trace elements is required to promote both fruit growth and oil content. The total sterol, squalene, total flavonoid, and polyphenol content of other treatments can be increased by up to 28.81%, 32.07%, 188.04%, and 92.61%, respectively, at most, compared to the control group. Selenium fertilizer and boron fertilizer increased the total sterol content in Camellia oil and had a significant positive correlation at the 0.01 level, but zinc fertilizer had little influence on it. High concentration selenium fertilizer generally increased the squalene, total flavonoid, and polyphenol content in Camellia oil, but boron and zinc fertilizers had little effect on these components. The results suggested that choosing appropriate fertilizer combinations could improve nutrient deficiency in C. oleifera and enhance the functional active compounds of its oil, thereby enhancing its value.
Simulation and Prediction of Sea Level Rise Impact on the Distribution of Mangrove and Spartina alterniflora in Coastal China
Authors: Zhang Yaqi , Cui Lina , Xie Deyu , Jiang Jiang
Published: April 2023

Sea level rise (SLR) has a significant impact on the vegetation ecosystem in coastal wetlands. Taking coastal China as the study area, the SLAMM (sea level rise affecting marsh model) was used to simulate the continuous long-term (2015–2100) effects of the spatiotemporal changes in mangrove and Spartina alterniflora in the four shared socioeconomic pathway scenarios (SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5) of sea level rise by 2100; then, ArcGis was used to assess and compare the impact of SLR on land use. The results are as follows. (1) The dramatic reduction in the vegetation area is positively correlated with the rate of sea level rise. (2) Tidal differences and sedimentation rates affect the response of mangrove and S. alterniflora distribution to sea level rise, as well as interactions between organisms. (3) The reasonable land use of coastal wetlands is important to researchers. Land use is one of the tools for effective mangrove conservation. In conclusion, in scientific research and production practice, it is important to combine the biotic and abiotic factors affecting the distribution of mangroves and S. alterniflora.
Specific Deoxyceramide Species Correlate with Expression of Macular Telangiectasia Type 2 (MacTel2) in a SPTLC2 Carrier HSAN1 Family
Authors: Wilson Lindsey , Saba Sadaf , Li Jun , Prasov Lev , Miller Jason
Published: April 2023

Hereditary sensory and autonomic neuropathy type 1 (HSAN1/HSN1) is a peripheral neuropathy most commonly associated with pathogenic variants in the serine palmitoyltransferase complex (SPTLC1, SPTLC2) genes, which are responsible for sphingolipid biosynthesis. Recent reports have shown that some HSAN1 patients also develop macular telangiectasia type 2 (MacTel2), a retinal neurodegeneration with an enigmatic pathogenesis and complex heritability. Here, we report a novel association of a SPTLC2 c.529A>G p.(Asn177Asp) variant with MacTel2 in a single member of a family that otherwise has multiple members afflicted with HSAN1. We provide correlative data to suggest that the variable penetrance of the HSAN1/MacTel2-overlap phenotype in the proband may be explained by levels of certain deoxyceramide species, which are aberrant intermediates of sphingolipid metabolism. We provide detailed retinal imaging of the proband and his HSAN1+/MacTel2- brothers and suggest mechanisms by which deoxyceramide levels may induce retinal degeneration. This is the first report of HSAN1 vs. HSAN1/MacTel2 overlap patients to comprehensively profile sphingolipid intermediates. The biochemical data here may help shed light on the pathoetiology and molecular mechanisms of MacTel2.
Decision-Making Preferences among Advanced Cancer Patients in a Palliative Setting in Jordan
Authors: Shamieh Omar , Alarjeh Ghadeer , Qadire Mohammad Al , Alrjoub Waleed , Abu-Nasser Mahmoud , Abu Farsakh Fadi , AlHawamdeh Abdelrahman , Al-Omari Mohammad , Amin Zaid , Ayaad Omar , Al-Tabba Amal , Hui David , Bruera Eduardo , Yennurajalingam Sriram
Published: April 2023

Understanding patients’ decision-making preferences is crucial for enhancing patients’ outcomes. The current study aims to identify Jordanian advanced cancer patients’ preferred decision-making and to explore the associated variables of the passive decision-making preference. We used a cross-sectional survey design. Patients with advanced cancer referred to the palliative care clinic at a tertiary cancer center were recruited. We measured patients’ decision-making preferences using the Control Preference Scale. Patients’ satisfaction with decision-making was assessed with the Satisfaction with Decision Scale. Cohen’s kappa statistic was used to assess the agreement between decision-control preferences and actual decision-making, and the bivariate analysis with 95% CI and the univariate and multivariate logistic regression were used to examine the association and predictors of the demographical and clinical characteristics of the participants and the participants’ decision-control preferences, respectively. A total of 200 patients completed the survey. The patients’ median age was 49.8 years, and 115 (57.5%) were female. Of them, 81 (40.5%) preferred passive decision control, and 70 (35%) and 49 (24.5%) preferred shared and active decision control, respectively. Less educated participants, females, and Muslim patients were found to have a statistically significant association with passive decision-control preferences. Univariate logistic regression analysis showed that, being a male (p = 0.003), highly educated (p = 0.018), and a Christian (p = 0.006) were statistically significant correlates of active decision-control preferences. Meanwhile, the multivariate logistic regression analysis showed that being a male or a Christian were the only statistically significant predictors of active participants’ decision-control preferences. Around 168 (84%) of participants were satisfied with the way decisions were made, 164 (82%) of patients were satisfied with the actual decisions made, and 143 (71.5%) were satisfied with the shared information. The agreement level between decision-making preferences and actual decision practices was significant (ⱪ coefficient = 0.69; 95% CI = 0.59 to 0.79). The study’s results demonstrate that a passive decision-control preference was prominent among patients with advanced cancer in Jordan. Further studies are needed to evaluate decision-control preference for additional variables, such as patients’ psychosocial and spiritual factors, communication, and information sharing preferences, throughout the cancer trajectory so as to inform policies and improve practice.
Climate-Related Natural Disasters: Reflections on an Agenda for Rural Health Research
Authors: Bailie Ross
Published: April 2023

The increasing frequency and severity of climate-related disasters will exacerbate the health inequities that already exist between people living in rural communities and those living in urban areas. There is a need to improve understanding of the differences in the impacts on and needs of rural communities, in order that policy, adaptation, mitigation, response and recovery efforts meet the needs of those who are most affected by flooding and who have the fewest resources to mitigate the impact and adapt to the increased flood risk. This paper is a reflection by a rural-based academic on the significance and experience of community-based flood-related research, with a discussion of the challenges and opportunities for research on rural health and climate change. From an equity perspective, there is a need for all analyses of national and regional datasets on climate and health to, wherever possible, examine the differential impacts and policy and practice implications for regional, remote and urban communities. At the same time, there is a need to build local capacity in rural communities for community-based participatory action research, and to enhance this capacity through building networks and collaborations between different researchers based in rural areas, and between rural- and urban-based researchers. We should also encourage the documentation, evaluation and sharing of experience and lessons from local and regional efforts to adapt to and mitigate the impacts of climate change on health in rural communities.
Physical Inactivity and Sedentary Behaviour among Panamanian Adults: Results from the National Health Survey of Panama (ENSPA) 2019
Authors: Montenegro Mendoza Roger , Roa Reina , Fontes Flavia , Moreno Velásquez Ilais , Quintana Hedley
Published: April 2023

Physical inactivity (PI) has been described as an independent risk factor for a large number of major non-communicable diseases and is associated with an increased risk of premature death. Additionally, sedentary behaviour has been associated with increased overall mortality. We estimated the national prevalence of PI and sedentary behaviour using the Global Physical Activity Questionnaire version 2. Using unconditional logistic regressions, the possible risk factors for PI were assessed. Over half of the people included in this study (54.9%; 95% CI: 54.1–57.3%) were physically inactive, with the median time spent engaged in sedentary behaviour being 120 min per day. Statistically significant associations with PI were observed with regard to sex, living area, and alcohol consumption. PI prevalence in Panama was elevated and showed a sex difference (women: 64.7%, 95% CI: 63.7–66.7%; men: 43.4%, 95% CI: 41.5–47.5%). According to our analysis of three-domain-related physical activities, the main contribution to the total estimated energy expenditure of physical activity/week came from the transport domain, followed by the work/household domain, and the least significant contributor was consistently the domain of exercise- and sports-related physical activities.
He Karanga Maha. Investigating Relational Resource Management in Aotearoa, New Zealand
Authors: Rewi Sarah , Hikuroa Daniel
Published: April 2023

Reciprocity amongst Māori peoples and the natural world is the foundation of the Māori worldview and natural resource management. Autonomy over resource management and the associated practices is an essential component of Māori wellbeing. This paper investigates the cultural, spiritual, historical, and ecological dimensions of mutton-bird harvesting, to gain a better understanding of the relational approach of Māori natural resource management. Resource management in Aotearoa New Zealand currently lacks the relational approach seen in Māori customary harvests. Therefore, the objective of this study is to identify the key values that underpin this cultural practice. Semi-structured interviews identified three key themes: harvesting practices, kaitiakitanga (resource management based on a Māori worldview), and whanaungatanga (kinship between people). Harvest practices had a bottom-up governance approach creating diverse harvesting techniques that adapt to local environments. Kaitiakitanga identified mana whenua rights to decision-making power in natural resource management as a requirement for success. Whanaungatanga also identified relationships and collaboration as a vital component. To optimize the best outcomes for the environment, we advocate for a genuine cross-cultural and relational approach and the inclusion of these practices and values in the governance of natural resources in Aotearoa New Zealand.
Preliminary Investigation on Hygienic-Sanitary Quality of Food Vending Machines
Authors: Caggiano Giuseppina , Marcotrigiano Vincenzo , D’Ambrosio Marilena , Marzocca Piersaverio , Spagnuolo Valentina , Fasano Fabrizio , Diella Giusy , Leone Anna Paola , Lopuzzo Marco , Sorrenti Domenico Pio , Sorrenti Giovanni Trifone , Montagna Maria Teresa
Published: April 2023

The consumption of hot drinks dispensed from vending machines has become a common practice, both in workplaces and during free time. Every day, millions of bulk drinks are sold, but the quality of the products distributed may not always be guaranteed, as it is related to many factors such as the quality of the water, the raw materials used, and the effectiveness of the equipment’s cleaning system. The purpose of this study is to evaluate the hygienic-sanitary requirements of hot drinks and vending machine surfaces. The investigation highlighted the microbial contamination of both coffee and vending machine surfaces. Although the ”coffee break” is usually considered a moment of pleasure, apparently not subject to specific jurisdiction, the products dispensed can represent a health risk if the hygienic conditions are not fully respected. Therefore, official controls carried out by the Prevention Department represent a suitable way for evaluating and guaranteeing the hygienic-sanitary requirements, providing for corrective actions, when needed, to protect consumers.
MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells
Authors: Han Peifeng , Sunada-Nara Keisuke , Kawashima Nobuyuki , Fujii Mayuko , Wang Shihan , Kieu Thoai Quoc , Yu Ziniu , Okiji Takashi
Published: April 2023

MicroRNA-146b-5p (miR-146b-5p) is up-regulated during and to suppress the inflammation process, although mechanisms involved in the action of miR-146b-5p have not been fully elucidated. This study examined the anti-inflammation effects of miR-146b-5p in lipopolysaccharide (LPS)-stimulated human dental pulp cells (hDPCs). An increase in human miR-146b-5p (hsa-miR-146b-5p) expression following the mRNA expression of pro-inflammatory cytokines was observed in LPS-stimulated hDPCs. The expression of hsa-miR-146b-5p and pro-inflammatory cytokines was down-regulated by a nuclear factor-kappa B (NF-κB) inhibitor, and the expression of hsa-miR-146b-5p was also decreased by a JAK1/2 inhibitor. Enforced expression of hsa-miR-146b-5p abolished phosphorylation of NF-κB p65 and down-regulated the expression of pro-inflammatory cytokines and NF-κB signaling components, such as interleukin-1 receptor-associated kinase 1 (IRAK1), tumor necrosis factor receptor-associated factor 6 (TRAF6), and REL-associated protein involved in NF-κB (RELA). Expression of rat miR-146b-5p (rno-miR-146b-5p) and pro-inflammatory cytokine mRNA was also up-regulated in experimentally-induced rat pulpal inflammation in vivo, and rno-miR-146b-5p blocked the mRNA expression of pro-inflammatory mediators and NF-κB signaling components in LPS-stimulated ex vivo cultured rat incisor pulp tissues. These findings suggest that the synthesis of miR-146b-5p is controlled via an NF-κB/IL6/STAT3 signaling cascade, and in turn, miR-146b-5p down-regulates the expression of pro-inflammatory mediators by targeting TRAF6, IRAK1, and RELA in LPS-stimulated hDPCs.
Influence of Contour Scan Variation on Surface, Bulk and Mechanical Properties of LPBF-Processed AlSi7Mg0.6
Authors: Buchenau Theresa , Amkreutz Marc , Bruening Hauke , Mayer Bernd
Published: April 2023

Metal additive manufacturing technologies have great potential for future use in load-bearing aerospace applications, requiring a deeper understanding of mechanical performance and influencing factors. The objective of this study was to investigate the influence of contour scan variation on surface quality, tensile and fatigue strength for laser powder bed fusion samples made of AlSi7Mg0.6 material and to create high-quality as-built surfaces. The samples were produced with identical bulk and different contour scan parameters to accommodate the investigation of the impact of as-built surface texture on mechanical properties. The bulk quality was evaluated by density measurements according to Archimedes’ principle and tensile testing. The surfaces were investigated using the optical fringe projection method, and surface quality was assessed by the areal surface texture parameters Sa (arithmetic mean height) and Sk (core height, derived from material ratio curve). Fatigue life was tested at different load levels, and the endurance limit was estimated based on a logarithmic-linear relation between number of cycles and stress. All samples were found to have a relative density of more than 99%. Surface conditions distinctive in Sa and Sk were successfully created. The resulting mean values of the ultimate tensile strength σult are between 375 and 405 MPa for 7 different surface conditions. It was confirmed that the influence of contour scan variation on bulk quality is insignificant for the assessed samples. Regarding fatigue, one as-built condition was found to perform as well as surface post-processed parts and better than the as-cast material (compared to literature values). The fatigue strength at the endurance limit for 106 cycles is between 45 and 84 MPa for the three considered surface conditions.
Vertical Graphene-Supported NiMo Nanoparticles as Efficient Electrocatalysts for Hydrogen Evolution Reaction under Alkaline Conditions
Authors: Wang Hongbin , Ye Beirong , Li Chen , Tang Tao , Li Sipu , Shi Shaojun , Wu Chunyang , Zhang Yongqi
Published: April 2023

Water electrolysis as an important and facile strategy to generate hydrogen has attracted great attention, and efficient electrocatalysts play a key role in hydrogen evolution reaction (HER). Herein, vertical graphene (VG)-supported ultrafine NiMo alloy nanoparticles (NiMo@VG@CC) were fabricated successfully via electro-depositing as efficient self-supported electrocatalysts for HER. The introduction of metal Mo optimized the catalytic activity of transition metal Ni. In addition, VG arrays as the three-dimensional (3D) conductive scaffold not only ensured high electron conductivity and robust structural stability, but also endowed the self-supported electrode large specific surface area and exposed more active sites. With the synergistic effect between NiMo alloys and VG, the optimized NiMo@VG@CC electrode exhibited a low overpotential of 70.95 mV at 10 mA cm−2 and a remarkable stable performance over 24 h. This research is anticipated to offer a powerful strategy for the fabrication of high-performance hydrogen evolution catalysts.
Surfactant-Free Decellularization of Porcine Auricular Cartilage Using Liquefied Dimethyl Ether and DNase
Authors: Kanda Hideki , Oya Kento , Wahyudiono  , Goto Motonobu
Published: April 2023

The most common decellularization method involves lipid removal using surfactant sodium dodecyl sulfate (SDS) and DNA fragmentation using DNase, and is associated with residual SDS. We previously proposed a decellularization method for the porcine aorta and ostrich carotid artery using liquefied dimethyl ether (DME), which is free from the concerns associated with SDS residues, instead of SDS. In this study, the DME + DNase method was tested on crushed porcine auricular cartilage tissues. Unlike with the porcine aorta and the ostrich carotid artery, it is important to degas the porcine auricular cartilage using an aspirator before DNA fragmentation. Although approximately 90% of the lipids were removed using this method, approximately 2/3 of the water was removed, resulting in a temporary Schiff base reaction. The amount of residual DNA in the tissue was approximately 27 ng/mg dry weight, which is lower than the regulatory value of 50 ng/mg dry weight. Hematoxylin and eosin staining confirmed that cell nuclei were removed from the tissue. Residual DNA fragment length assessment by electrophoresis confirmed that the residual DNA was fragmented to less than 100 bp, which was lower than the regulatory limit of 200 bp. By contrast, in the uncrushed sample, only the surface was decellularized. Thus, although limited to a sample size of approximately 1 mm, liquefied DME can be used to decellularize porcine auricular cartilage. Thus, liquefied DME, with its low persistence and high lipid removal capacity, is an effective alternative to SDS.
Influences of Ultrafine Ti(C, N) on the Sintering Process and Mechanical Properties of Micron Ti(C, N)-Based Cermets
Authors: Ma Lili , Zhao Zaiyang , Wu Yurong , Sun Jingjing , Gu Siyong , Zhang Houan
Published: April 2023

For investigating the influence mechanism underlying ultrafine Ti(C, N) within micron Ti(C, N)-based cermets, three cermets including diverse ultrafine Ti(C, N) contents were employed. In addition, for the prepared cermets, their sintering process, microstructure, and mechanical properties were systematically studied. According to our findings, adding ultrafine Ti(C, N) primarily affects the densification and shrinkage behavior in the solid-state sintering stage. Additionally, material-phase and microstructure evolution were investigated under the solid-state stage from 800 to 1300 °C. Adding ultrafine Ti(C, N) enhanced the diffusion and dissolution behavior of the secondary carbide (Mo2C, WC, and (Ta, Nb)C) under a lower sintering temperature of 1200 °C. Further, as sintering temperature increased, adding ultrafine Ti(C, N) enhanced heavy element transformation behaviors in the binder phase and accelerated solid-solution (Ti, Me) (C, N) phase formation. When the addition of ultrafine Ti(C, N) reached 40 wt%, the binder phase had increased its liquefying speed. Moreover, the cermet containing 40 wt% ultrafine Ti(C, N) displayed superb mechanical performances.
Investigation of Selected Surface Topography Parameters and Deformation during Milling of Vertical Thin-Walled Structures from Titanium Alloy Ti6Al4V
Authors: Kurpiel Szymon , Zagórski Krzysztof , Cieślik Jacek , Skrzypkowski Krzysztof
Published: April 2023

Thin-walled elements are widely used in the aerospace industry, where the aim is to reduce the process time and the weight of the structure while ensuring the sufficient quality of the finished product. Quality is determined by geometric structure parameters and dimensional and shape accuracy. The main problem encountered during the milling of thin-walled elements is the deformation of the product. Despite the various methods available for measuring deformation, more are still being developed. This paper presents selected surface topography parameters and deformation of vertical thin-walled elements during an experiment under controlled cutting conditions for samples from titanium alloy Ti6Al4V. Constant parameters of feed (f), cutting speed (Vc,) and tool diameter (D) were used. Samples were milled using a tool for general-purpose and a tool for high-performance machining, as well as two different machining approaches: with greater involvement of face milling, and cylindrical milling with a constant material removal rate (MRR). For samples with vertical thin walls, the parameters of waviness (Wa, Wz,) and roughness (Ra, Rz) were measured using a contact profilometer in the selected areas on both processed sides. Deformations were determined in selected cross-sections perpendicular and parallel to the bottom of the sample using GOM measurement (GOM—Global Optical Measurement). The experiment showed the possibility of measuring deformations and deflection arrows of thin-walled elements proceeded from titanium alloy using GOM measurement. Differences in selected surface topography parameters and deformations were observed for the machining methods used with an increased cross-section of the cut layer. A sample with a deviation of 0.08 mm from the assumed shape was obtained.
Excellent Uniformity and Properties of Micro-Meter Thick Lead Zirconate Titanate Coatings with Rapid Thermal Annealing
Authors: Ma Youcao , Song Jian , Zhao Yuyao , Tanaka Kiyotaka , Wu Shijunbo , Dong Chao , Wang Xubo , Kanno Isaku , Ouyang Jun , Zhou Jia , Liu Yue
Published: April 2023

Lead zirconate titanate (PZT) films have shown great potential in piezoelectric micro-electronic-mechanical system (piezo-MEMS) owing to their strong piezoelectric response. However, the fabrication of PZT films on wafer-level suffers with achieving excellent uniformity and properties. Here, we successfully prepared perovskite PZT films with similar epitaxial multilayered structure and crystallographic orientation on 3-inch silicon wafers, by introducing a rapid thermal annealing (RTA) process. Compared to films without RTA treatment, these films exhibit (001) crystallographic orientation at certain composition that expecting morphotropic phase boundary. Furthermore, dielectric, ferroelectric and piezoelectric properties on different positions only fluctuate within 5%. The relatively dielectric constant, loss, remnant polarization and transverse piezoelectric coefficient are 850, 0.1, 38 μC/cm2 and −10 C/m2, respectively. Both uniformity and properties have reached the requirement for the design and fabrication of piezo-MEMS devices. This broadens the design and fabrication criteria for piezo-MEMS, particularly for piezoelectric micromachined ultrasonic transducers.
Modeling of Severe Plastic Deformation by HSHPT of As-Cast Ti-Nb-Zr-Ta-Fe-O Gum Alloy for Orthopedic Implant
Authors: Bîrsan Dan Cătălin , Gurău Carmela , Marin Florin-Bogdan , Stefănescu Cristian , Gurău Gheorghe
Published: April 2023

The High Speed High Pressure Torsion (HSHPT) is the severe plastic deformation method (SPD) designed for the grain refinement of hard-to-deform alloys, and it is able to produce large, rotationally complex shells. In this paper, the new bulk nanostructured Ti-Nb-Zr-Ta-Fe-O Gum metal was investigated using HSHPT. The biomaterial in the as-cast state was simultaneously compressed up to 1 GPa and torsion was applied with friction at a temperature that rose as a pulse in less than 15 s. The interaction between the compression, the torsion, and the intense friction that generates heat requires accurate 3D finite element simulation. Simufact Forming was employed to simulate severe plastic deformation of a shell blank for orthopedic implants using the advancing Patran Tetra elements and adaptable global meshing. The simulation was conducted by applying to the lower anvil a displacement of 4.2 mm in the z-direction and applying a rotational speed of 900 rpm to the upper anvil. The calculations show that the HSHPT accumulated a large plastic deformation strain in a very short time, leading to the desired shape and grain refinement.
Research on a Method to Improve the Temperature Performance of an All-Silicon Accelerometer
Authors: Liu Guowen , Liu Yu , Ma Xiao , Wang Xuefeng , Zheng Xudong , Jin Zhonghe
Published: April 2023

This paper presents a novel method for the performance of an all-silicon accelerometer by adjusting the ratio of the Si-SiO2 bonding area, and the Au-Si bonding area in the anchor zone, with the aim of eliminating stress in the anchor region. The study includes the development of an accelerometer model and simulation analysis which demonstrates the stress maps of the accelerometer under different anchor–area ratios, which have a strong impact on the performance of the accelerometer. In practical applications, the deformation of the comb structure fixed by the anchor zone is influenced by the stress in the anchor region, causing a distorted nonlinear response signal. The simulation results demonstrate that when the area ratio of the Si-SiO2 anchor zone to the Au-Si anchor zone decreases to 0.5, the stress in the anchor zone decreases significantly. Experimental results reveal that the full-temperature stability of zero-bias is optimized from 133 μg to 46 μg when the anchor–zone ratio of the accelerometer decreases from 0.8 to 0.5. At the same time, the full-temperature stability of the scale factor is optimized from 87 ppm to 32 ppm. Furthermore, zero-bias full-temperature stability and scale factor full-temperature stability are improved by 34.6% and 36.8%, respectively.
Determination of Hypoglycemic, Hypolipidemic and Nephroprotective Effects of Berberis Calliobotrys in Alloxan-Induced Diabetic Rats
Authors: Rasool Shahid , Al Meslmani Bassam , Alajlani Muaaz
Published: April 2023

Many plants of the Berberis genus have been reported pharmacologically to possess anti-diabetic potential, and Berberis calliobotrys has been found to be an inhibitor of α-glucosidase, α-amylase and tyrosinase. Thus, this study investigated the hypoglycemic effects of Berberis calliobotrys methanol extract/fractions using in vitro and In vivo methods. Bovine serum albumin (BSA), BSA–methylglyoxal and BSA–glucose methods were used to assess anti-glycation activity in vitro, while in vivo hypoglycemic effects were determined by oral glucose tolerance test (OGTT). Moreover, the hypolipidemic and nephroprotective effects were studied and phenolics were detected using high performance liquid chromatography (HPLC). In vitro anti-glycation showed a significant reduction in glycated end-products formation at 1, 0.25 and 0.5 mg/mL. In vivo hypoglycemic effects were tested at 200, 400 and 600 mg/kg by measuring blood glucose, insulin, hemoglobin (Hb) and HbA1c. The synergistic effect of extract/fractions (600 mg/kg) with insulin exhibited a pronounced glucose reduction in alloxan diabetic rats. The oral glucose tolerance test (OGTT) demonstrated a decline in glucose concentration. Moreover, extract/fractions (600 mg/kg) exhibited an improved lipid profile, increased Hb, HbA1c levels and body weight for 30 days. Furthermore, diabetic animals significantly exhibited an upsurge in total protein, albumin and globulin levels, along with a significant improvement in urea and creatinine after extract/fractions administration for 42 days. Phytochemistry revealed alkaloids, tannins, glycosides, flavonoids, phenols, terpenoids and saponins. HPLC showed the presence of phenolics in ethyl acetate fraction that could be accountable for pharmacological actions. Therefore, it can be concluded that Berberis calliobotrys possesses strong hypoglycemic, hypolipidemic and nephroprotective effects, and could be a potential therapeutic agent for diabetes treatment.
Full Regio- and Stereoselective Protocol for the Synthesis of New Nicotinoids via Cycloaddition Processes with the Participation of Trans-Substituted Nitroethenes: Comprehensive Experimental and MEDT Study
Authors: Kras Jowita , Woliński Przemysław , Nagatsky Roman , Demchuk Oleg M. , Jasiński Radomir
Published: April 2023

[3 + 2] Cycloaddition reactions with the participation of Z-C-(3-pyridyl)-N-methylnitrone and series of E-2-R-nitroethenes were both experimentally and theoretically explored in the framework of Molecular Electron Density Theory. It was found that all considered processes are realized under mild conditions and in full regio- and stereocontrol. The ELF analysis additionally showed that the studied reaction proceeds by a two-stage, one-step mechanism.
Association of Body Iron Metabolism with Type 2 Diabetes Mellitus in Chinese Women of Childbearing Age: Results from the China Adult Chronic Disease and Nutrition Surveillance (2015)
Authors: Feng Jie , Shan Xiaoyun , Wang Lijuan , Lu Jiaxi , Cao Yang , Yang Lichen
Published: April 2023

High iron stores have been reported to be associated with type 2 diabetes mellitus (T2DM). However, evidence for the associations of iron metabolism with T2DM is inconsistent, and whether there is a threshold effect remains controversial. In the present study, we aimed to examine the associations between various iron biomarkers and the risk of T2DM as well as impaired glucose metabolism (IGM) and hyperglycemia in Chinese women of childbearing age. A total of 1145 women were divided into three groups (normal blood glucose metabolism group; IGM group; T2DM group). Biomarkers of iron metabolism (serum ferritin (SF), transferrin, soluble transferrin receptor (sTfR), transferrin saturation, serum iron, total body iron, and sTfR-to-lgferritin index) were measured. After adjusting for various confounding risk factors, SF and sTfR were positively associated with the risk of IGM (fourth vs. first quartile: SF odds ratio (OR) = 1.93 (95% CI 1.17–3.20) and sTfR OR = 3.08 (95% CI 1.84–5.14)) and T2DM (SF OR = 2.39 (95% CI 1.40–4.06) and sTfR OR = 3.84 (95% CI 2.53–5.83)). There was a nonlinear relationship between SF and risk of T2DM and hyperglycemia (p for nonlinearity < 0.01). Our findings suggested that SF and sTfR could be independent predictors of T2DM risk.
A Study on the Interoperability Technology of Digital Identification Based on WACI Protocol with Multiparty Distributed Signature
Authors: Kim Jihwan , Kim Pyung , Choi Daeseon , Lee Younho
Published: April 2023

In digital identity authentication, credentials are typically stored in a digital wallet and authenticated through a single key-based signature and public key verification. However, ensuring compatibility between systems and credentials can be challenging and the existing architecture can create a single point of failure, which can hinder system stability and prevent data interchange. To address this problem, we propose a multiparty distributed signature structure using FROST, a Schnorr signature-based threshold signature algorithm, applied to the WACI protocol framework for credential interaction. This approach eliminates a single point of failure and secures the signer’s anonymity. Additionally, by following standard interoperability protocol procedures, we can ensure interoperability during the exchange of digital wallets and credentials. This paper presents a method that combines a multiparty distributed signature algorithm and an interoperability protocol, and discusses the implementation results.
Femtosecond Inscription of a Fiber Bragg Grating Spectral Array in the Same Spatial Location
Authors: Halstuch Aviran , Ishaaya Amiel A.
Published: April 2023

A five fiber Bragg grating (FBG) array is inscribed at the same spot with a single uniform phase-mask (PM). The inscription setup consists of a near-infrared femtosecond laser, a PM, a defocusing spherical lens and a cylindrical focusing lens. The tunability of the center Bragg wavelength is achieved by a defocusing lens, and by translating the PM, which results in a different magnification of the PM. A first FBG is inscribed, followed by four cascading FBGs, which are inscribed exactly at the same spot only after the translation of the PM. The transmission and reflection spectra of this array are measured, showing a second-order Bragg wavelength at ~1.56 µm with a transmission dip of ~−8 dB. The spectral wavelength shift between each consecutive FBG is ~2.9 nm, and the total wavelength shift is ~11.7 nm. The reflection spectrum of the third-order Bragg wavelength is measured at ~1.04 µm, showing a wavelength separation of ~1.97 nm between neighboring FBGs, and the total spectral span between the first FBG and the last one is ~8 nm. Finally, the wavelength sensitivity to strain and temperature is measured.
FSVM: A Few-Shot Threat Detection Method for X-ray Security Images
Authors: Fang Cheng , Liu Jiayue , Han Ping , Chen Mingrui , Liao Dayu
Published: April 2023

In recent years, automatic detection of threats in X-ray baggage has become important in security inspection. However, the training of threat detectors often requires extensive, well-annotated images, which are hard to procure, especially for rare contraband items. In this paper, a few-shot SVM-constraint threat detection model, named FSVM is proposed, which aims at detecting unseen contraband items with only a small number of labeled samples. Rather than simply finetuning the original model, FSVM embeds a derivable SVM layer to back-propagate the supervised decision information into the former layers. A combined loss function utilizing SVM loss is also created as the additional constraint. We have evaluated FSVM on the public security baggage dataset SIXray, performing experiments on 10-shot and 30-shot samples under three class divisions. Experimental results show that compared with four common few-shot detection models, FSVM has the highest performance and is more suitable for complex distributed datasets (e.g., X-ray parcels).
On-Line Evaluation and Monitoring of Security Features of an RO-Based PUF/TRNG for IoT Devices
Authors: Rojas-Muñoz Luis F. , Sánchez-Solano Santiago , Martínez-Rodríguez Macarena C. , Brox Piedad
Published: April 2023

The proliferation of devices for the Internet of Things (IoT) and their implication in many activities of our lives have led to a considerable increase in concern about the security of these devices, posing a double challenge for designers and developers of products. On the one hand, the design of new security primitives, suitable for resource-limited devices, can facilitate the inclusion of mechanisms and protocols to ensure the integrity and privacy of the data exchanged over the Internet. On the other hand, the development of techniques and tools to evaluate the quality of the proposed solutions as a step prior to their deployment, as well as to monitor their behavior once in operation against possible changes in operating conditions arising naturally or as a consequence of a stress situation forced by an attacker. To address these challenges, this paper first describes the design of a security primitive that plays an important role as a component of a hardware-based root of trust, as it can act as a source of entropy for True Random Number Generation (TRNG) or as a Physical Unclonable Function (PUF) to facilitate the generation of identifiers linked to the device on which it is implemented. The work also illustrates different software components that allow carrying out a self-assessment strategy to characterize and validate the performance of this primitive in its dual functionality, as well as to monitor possible changes in security levels that may occur during operation as a result of device aging and variations in power supply or operating temperature. The designed PUF/TRNG is provided as a configurable IP module, which takes advantage of the internal architecture of the Xilinx Series-7 and Zynq-7000 programmable devices and incorporates an AXI4-based standard interface to facilitate its interaction with soft- and hard-core processing systems. Several test systems that contain different instances of the IP have been implemented and subjected to an exhaustive set of on-line tests to obtain the metrics that determine its quality in terms of uniqueness, reliability, and entropy characteristics. The results obtained prove that the proposed module is a suitable candidate for various security applications. As an example, an implementation that uses less than 5% of the resources of a low-cost programmable device is capable of obfuscating and recovering 512-bit cryptographic keys with virtually zero error rate.
Ball Detection Using Deep Learning Implemented on an Educational Robot Based on Raspberry Pi
Authors: Keča Dominik , Kunović Ivan , Matić Jakov , Sovic Krzic Ana
Published: April 2023

RoboCupJunior is a project-oriented competition for primary and secondary school students that promotes robotics, computer science and programing. Through real life scenarios, students are encouraged to engage in robotics in order to help people. One of the popular categories is Rescue Line, in which an autonomous robot has to find and rescue victims. The victim is in the shape of a silver ball that reflects light and is electrically conductive. The robot should find the victim and place it in the evacuation zone. Teams mostly detect victims (balls) using random walk or distant sensors. In this preliminary study, we explored the possibility of using a camera, Hough transform (HT) and deep learning methods for finding and locating balls with the educational mobile robot Fischertechnik with Raspberry Pi (RPi). We trained, tested and validated the performance of different algorithms (convolutional neural networks for object detection and U-NET architecture for sematic segmentation) on a handmade dataset made of images of balls in different light conditions and surroundings. RESNET50 was the most accurate, and MOBILENET_V3_LARGE_320 was the fastest object detection method, while EFFICIENTNET-B0 proved to be the most accurate, and MOBILENET_V2 was the fastest semantic segmentation method on the RPi. HT was by far the fastest method, but produced significantly worse results. These methods were then implemented on a robot and tested in a simplified environment (one silver ball with white surroundings and different light conditions) where HT had the best ratio of speed and accuracy (4.71 s, DICE 0.7989, IoU 0.6651). The results show that microcomputers without GPUs are still too weak for complicated deep learning algorithms in real-time situations, although these algorithms show much higher accuracy in complicated environment situations.
An Adaptive Simultaneous Multi-Protocol Extension of CRAFT
Authors: Moreau Louis , Conchon Emmanuel , Sauveron Damien
Published: April 2023

An exponential number of devices connect to Internet of Things (IoT) networks every year, increasing the available targets for attackers. Protecting such networks and devices against cyberattacks is still a major concern. A proposed solution to increase trust in IoT devices and networks is remote attestation. Remote attestation establishes two categories of devices, verifiers and provers. Provers must send an attestation to verifiers when requested or at regular intervals to maintain trust by proving their integrity. Remote attestation solutions exist within three categories: software, hardware and hybrid attestation. However, these solutions usually have limited use-cases. For instance, hardware mechanisms should be used but cannot be used alone, and software protocols are usually efficient in particular contexts, such as small networks or mobile networks. More recently, frameworks such as CRAFT have been proposed. Such frameworks enable the use of any attestation protocol within any network. However, as these frameworks are still recent, there is still considerable room for improvement. In this paper, we improve CRAFT’s flexibility and security by proposing ASMP (adaptative simultaneous multi-protocol) features. These features fully enable the use of multiple remote attestation protocols for any devices. They also enable devices to seamlessly switch protocols at any time depending on factors such as the environment, context, and neighboring devices. A comprehensive evaluation of these features in a real-world scenario and use-cases demonstrates that they improve CRAFT’s flexibility and security with minimal impact on performance.