bluuebunny/crossref_metadata_2025 huggingface dataset:
STAFF TRAINING AS AN ELEMENT OF THE COMPANY'S PERSONNEL POLICY IN A CHANGING SECURITY ENVIRONMENT AND IN THE UPDATE OF CRISIS SITUATIONS IN THE ECONOMY
Authors:   Львівський державний університет внутрішніх справ, Копитко Марта
Published: April 2023

ійна в Україні суттєво змінила умови функціонування бізнесу. Під вплив таких викликів, загроз та небезпек український бізнес ще не потрапляв. У зв’язку з цим бізнесу довелося адаптуватися, змінювати місце дислокації виробничих потужностей, працювати в зоні підвищеного ризику із недоукомплектованим штатом, зруйнованими логістичними ланцюгами, дефіцитом товарів та комплектуючих, суттєвим зниженням рівня попиту, високим рівнем інфляції та переорієнтацією державної політики у сектор оборони із зниженням рівня підтримки бізнесу. Але, незважаючи на такий ряд дестабілізуючих чинників вітчизняне бізнес-середовище не зупинилося, а продовжує функціонувати. У статті на основі статистичних даних, результатів опитувань підприємців та аналітичних даних обґрунтовано вплив змін у зовнішньому середовищі на рівень функціонування вітчизняних підприємств і на наслідки у кадровій сфері. Базуючись на цих умовах, визначено перспективним методом налагодження роботи та втримання рівня конкурентоспроможності – зміни в кадровій політиці. Важливим аспектом налагодження роботи в складний умовах війни є удосконалення процесів кадрової політики, що передбачає максимальну підтримку усіх працівників. За умови дефіциту кадрів актуалізується питання їх підготовки та навчання. Тому, дослідження побудоване на аналізі перспективних методів навчання персоналу з врахуванням мотиваційних аспектів та впливу агресивних загроз зовнішнього середовища. Визначено перелік переваг для роботодавців внаслідок навчання персоналу, зокрема, - це можливість забезпечити підприємство високопрофесійними кадрами, які здатні вирішувати найскладніші завдання; знизити плинність кадрів, сформувати кадровий резерв, знизити витрати на підбір кадрів та підвищити рівень мотивації співробітників. Крім того, систематизовано перелік переваг для працівників: набуття нових професійних знань і навичок, можливість отримати вищу зарплату, посадове підвищення кваліфікації, впевненість у майбутньому,відсутність страху втратити роботу, зростання поваги і вдячності, підвищення мотивації праці. З метою заохочення працівників до навчання запропоновано реалізовувати наступні кроки: підтримувати позитивне навчальне середовище; дорослі особи досягають найвищих академічних досягнень, коли їх навчання супроводжується фізичним, розумовим та емоційним комфортом; залучати осіб до сучасної методики навчання; використовувати елемент співпраці між особами, які навчаються; використовувати різноманітні методи навчання; використовувати відступи в сучасній методиці навчання.
PROSPECTS FOR THE DEVELOPMENT OF SOCIAL RESPONSIBILITY BASED ON THE EXPERIENCE OF GLOBAL PHARMACEUTICAL COMPANIES
Authors:   Дніпровський національний університет імені Олеся Гончара, Карпюк Злата , Крупський Олександр ,   Дніпровський національний університет імені Олеся Гончара, Стасюк Юлія ,   Дніпровський національний університет імені Олеся Гончара
Published: April 2023

Політика соціальної відповідальності стає невід’ємною частиною діяльності компаній, оскільки охоплює діяльність, спрямовану на задоволення вимог усіх зацікавлених сторін, підтримання сталого екологічного стану та заходи, що забезпечують соціальну сферу (підтримка освітніх проектів, допомога вразливим верствам населення та ін.) Автори обговорюють підходи до соціальної відповідальності, які залежать від ступеня врахування інтересів стейкхолдерів. У статті досліджено соціальну відповідальність світових фармацевтичних компаній з багатою історією та досвідом. Їх діяльність у сфері соціальної відповідальності базується на трьох ключових сферах, а саме: навколишнє середовище, суспільство та управління організацією. У роботі також аналізуються особливості розвитку соціальної відповідальності вітчизняного бізнесу, досліджується діяльність провідних українських компаній у цій сфері, на які суттєво впливають сучасні події в нашій країні. Основою внутрішньої соціальної відповідальності вітчизняних фармацевтичних компаній є підвищення якості трудової діяльності працівників. Зовнішня форма соціальної відповідальності включає бізнес-практики, пов’язані з впровадженням систем управління якістю, систем управління навколишнім середовищем, соціально орієнтованих систем управління та соціальної відповідальності, спрямованих на побудову партнерських відносин з ключовими зацікавленими сторонами. На основі проведеного дослідження авторами описано основні перспективи розвитку соціальної відповідальності на вітчизняних підприємствах, зокрема фармацевтичного сектору, та шляхи її вдосконалення. Лише незначна частина з них повноцінно займається соціальною діяльністю, розвиток якої також стримується недостатнім фінансуванням, відсутністю пільг кредитування соціально спрямованих проектів та недостатніми законодавчо закріпленими пільгами соціально відповідального бізнесу.
BORIC ACID AMELIORATES LIVER INJURY IN RAT INDUCED BY CYCLOPHOSPHAMIDE
Authors: ÖNDER Gözde Özge , GÖKTEPE Özge , OKUR Eda , CENGİZ MAT Özge , BOLAT Demet , BALCIOĞLU Esra , YAY Arzu
Published: April 2023

Introduction: The aim of the current study was to look into any potential ameliorative benefits of boric acid on liver damage in rats caused by cyclophosphamide (CTX).

Materials and Methods: Four groups; control, boric acid, CTX, and boric acid + CTX, were created. Female Wistar albino rats were given daily injections of CTX (75 mg/kg) to create the liver damage model. Cyclophosphamide (75 mg/kg) was administered intraperitoneally, and boron (1.3 g/rat/day) was administered by gavage every day for two weeks in the boric acid+CTX group. The histopathological changes were evaluated in ovarian tissue staining with hematoxylin and eosin, masson tricrom, and periodic acid Schiff. We assessed ovarian tissue enzyme activity as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px).

Results: Images in the boric acid+CTX group had lower histological evaluations than those in the CTX group under the light microscope. According to the findings, boric acid reduced the levels of malondialdehyde (MDA) in the liver tissues. Additionally, boric acid improved the actions of oxidative stress indicators to reduce oxidative stress brought on by CTX and upregulated antioxidant parameters.

Conclusion: In conclusion, our study have demonstrated that CTX- induced liver injury can be alleviated by reducing the tissue MDA levels, increasing the liver’s SOD, GSH-Px, and CAT activities. In order to reduce the liver damage caused by CTX, boric acid may be administered as a dietary supplement or functional food.
Pengaruh Biaya Promosi Terhadap Kinerja Perusahaan Pada UMKM Di Palembang
Authors: Panjaitan Delfi , Lesmana Desy , Maimunah Mutiara
Published: April 2023

ABSTRACT

 

This study aims to determine the effect of promotion costs on company performance at MSMEs in Palembang City. The population of this research is all owners/managers of MSMEs in Palembang City. The sample in this study is the owner/manager of the food and/or beverage sector in the city of Palembang. The sample is set at 100 respondents. Data was collected by distributing questionnaires. The research analysis method used is simple linear regression. The results of the study indicate that promotion costs affect the company's performance on MSMEs in Palembang City.

 

Keywords: promotion costs, company performance, sales volume.

 

 

ABSTRAK

 

Penelitian ini bertujuan untuk mengetahui pengaruh biaya promosi terhadap kinerja perusahaan pada UMKM di Kota Palembang. Populasi penelitian ini adalah seluruh pemilik/pengelola UMKM di Kota Palembang. Sampel pada penelitian ini pemilik/pengelola UMKM sektor makanan dan atau minuman di Kota Palembang. Sampel ditetapkan sebanyak 100 responden. Data dikumpulkan dengan pembagian kuisoner. Metode analisis penelitian yang digunakan adalah regresi linier sederhana.   Hasil penelitian menunjukkan bahwa biaya promosi mempengaruhi kinerja perusahaan pada UMKM di Kota Palembang.

 

Kata Kunci : biaya promosi, kinerja perusahaan, volume penjualan.
The Reading Habit in University Education
Authors: Chuchuca Basantes Fernando , Chuchuca Basantes Iván
Published: April 2023

This research was conducted in the university system, with the objective of determining the existence of the reading habit in a segment of its students and how this frequent behavior affects their academic performance. To fulfill this purpose, the population was focused on the seventh semester of the Language and Linguistics career at the University of Guayaquil, to know from their texts the existence of the reading habit and if the documents read have contributed in their learning and academic performance.  The research was framed in the non-experimental qualitative paradigm, with a correlational, transversal, simple descriptive, phenomenological and hermeneutic approach, because it allowed us to encapsulate the opinions of the students at a specific moment, and with this information to analyze and interpret their reading behaviors, and the subsequent connotations.
ANALISIS QUALITY INFORMATION SYSTEM (QIS) MENGGUNAKAN MODEL ISO 9126 PADA SIAKAD
Authors: Moh. Ali Fikri  , Riyan Farismana  , Dita Rizki Amalia
Published: April 2023

Mengukur kualitas sebuah sistem informasi dapat dinilai melalui ukuran-ukuran dan metde-metode tertentu. Salah satu standar yang mejadi tolak ukur kualitas perangkat lunak adalah ISO 9126, yang dibuat oleh International Organization for Standardization (ISO) dan International Electrotechnical Commission (IEC) yang sudah diakui secara internasional. Dimana standar ini mendefinisikan kualitas produk perangkat lunak, model, karakteristik mutu, dan metrik terkait yang digunakan untuk mengevaluasi dan menetapkan kualitas sebuah produk software. Terdapat enam faktor kualitas menurut ISO 9126 yaitu functionality, reability, usability, efficiency, maintainability, dan portability. Berdasarkan standar ISO 9126 hasil analisis Quality Information System (QIS) meggunakan Model ISO 9126 pada SIAKAD memperoleh nilai functionality sebesar 20,16% dan kemudian usability sebesar 20,01%, probability sebesar 15,99%, maintainability 15,95%, efficiency sebesar 15,90% dan yang terkecil reliability efficiency sebesar 11,99%.    Dengan demikian kualitas sistem informasi SIAKAD sangat baik di tingkat Functionality dan kurang baik pada tingkat Efficiency. Berdasarkan gambar 5 menyatakan bahwa Quality Sistem Information (QIS) memperoleh nilai 75,80%. Dengan demikian melalui analisis kategori QIS pada SIAKAD Politeknik Negeri Indramayu yaitu Baik. Sedangkan 24,20% menurut responden menyatakan Kurang Baik.
Oncologic surgery in the era of drug therapy
Authors: Egorenkov V.V.
Published: April 2023

Surgical oncology has undergone a number of tactical changes in the era of the development of drug therapy, but is still the only treatment that can cure most solid forms of cancer. Recently, surgical interventions are increasingly acquiring an individual approach to the patient. Surgical oncology is part of a multifaceted multidisciplinary team with a single philosophy in understanding the biology of tumor development, as well as the contribution of other disciplines to the treatment of cancer patients. Key words: surgical oncology, cytoreductive surgery, intraoperative chemotherapy.
Overall survival of patients with hepatocellular carcinoma of different etiologies
Authors: Petkau V.V. , Bessonova E.N. , Breder V.V. , Kiselev Е.А. , Kiseleva К.Е.
Published: April 2023

Key words: hepatocellular carcinoma, overall survival, prognostic factors, etiology
An Analysis of the Challenges Faced by Small-Scale Farmers and their Response to the 2014-2016 Drought in Mfekayi, Mtubatuba, KZN, South Africa
Authors: Bukhosini Ziphozethu , Moyo Inocent
Published: April 2023

Small-scale farming contributes to poverty reduction and the improvement of living standards in impoverished rural communities. However, in South Africa, the drought continues to threaten the operations, incomes, and livelihoods of small-scale farmers. Against this backdrop, this paper analyses small scale farmers’ responses to the 2014-2016 droughts in Mfekayi, in the KwaZulu Natal province of South Africa. The study adopted a mixed-method approach in the form of a convergent parallel design. The results indicated that there were various measures taken by small-scale farmers to respond to the drought. These actions include buying expensive supplements, crop variation, and the application of indigenous knowledge such as livestock movement. Moreover, the results stipulated that those participants suffered livestock deaths and crop failure as the major impacts of drought. In addition, there are challenges experienced by small-scale farmers in dealing with drought, such as further livestock deaths, drought recovery costs, and a lack of information. The study recommends that the government provides relief assistance and come up with policies that specifically address the concerns of small scale farmers.
Assessing the role of Culture as a Social Determinant of Health and a Deterrent to MSM Accessing Health Services in KwaZulu-Natal Province, South Africa
Authors: Albert Ikhile Ikekhwa , Mavhandu-Mudzui Azwihangwisi Helen
Published: April 2023

Abstract To date, few studies have been published focusing on the impact of culture on the health of men who have Sex with Men (MSM) health. This study aims to assess the impact culture has on MSM health. Studies have shown that better access to health services among MSM improves their health and reduces the transmission of HIV/AIDS. However, MSM in KwaZulu-Natal Province still face hindrances in accessing health services. This study gathered data using in-depth interviews with 25 MSM in KwaZulu-Natal in 2020. The data were analysed using the interpretative phenomenological analysis (IPA) framework. It was discovered that culture as a key social determinant of health factors have been categorised as a significant factor that determines the health and wellbeing of MSM in accessing health services, using stigma and discrimination as a barrier stick. Culture was identified in this study as a critical triggering factor that prevents MSM from accessing health services. The engagement and involvement of cultural influencers are recommended in this study for MSM focal programme designers, implementers, and policymakers to address identified cultural barriers to enhance access to health services for MSM.
Expression of (TTF-1), CK-7 and CK-20 Immunohistochemical Marker in Neoplastic and Non-neoplastic Endometrium.
Authors: AL-Atrooshi Sazan A. , Hameedi Ameer D. , Zaboon Zainab A.
Published: April 2023

Background: Thyroid transcription factor-1 (TTF-1) is a protein that is well known to be expressed immunohistochemically in normal and neoplastic thyroid and pulmonary tissues. However; increasing studies have showed its expression in normal tissues and tumors of other organs including endometrium. These facts are important to be considered in the use of this marker in the differential diagnosis of carcinoma of unknown origin and make it important to use it as a part of a panel of immunohistochemical stains. In this setting Cytokeratin 7 and 20(CK-7&CK-20) are important since they have different coordinate expression profile in different organs and tumors.Obejectives: This study is designed to assess expression of TTF-1, CK-7 and CK-20 in neoplastic and nonneoplastic endometrium.Patients and Methods: Thirty six cases have been studied including 23 case of endometrial carcinoma and 13 cases of non-neoplastic endometrium including cases of irregular secretory endometrium, simple hyperplasia, complex hyperplasia, complex atypical hyperplasia, and atrophic endometrium.The study performed in the Baghdad medical city from May 2013 to December 2013Results: Two cases out of 23 cases of endometrial carcinoma (8.7%) showed expression of TTF-1 and none of the non-neoplastic endometrial cases showed any expression. Twenty one (91.3%) of 23 cases of endometrial carcinoma and all non-neoplastic endometrial cases showed expression for cytokeratin 7 with different scores.Neither neoplastic nor non-neoplastic endometrium showed expression for cytokeratin 20.Conclusion:We concluded that although TTF-1 regarded as a marker for thyroid and pulmonary tissues (and tumors); other tumors “including cases of endometrial carcinomas can showed TTF-1 expression. CK7+ve/CK20-ve profile of endometrial carcinoma is important to consider in assessment of carcinoma of unknown origin especially if combined with TTF-1.
Effect of Body mass index on interleukin2, 6 and soluble fibroblast associated surface antigen in infertile men
Authors: Jaafar Israa Faeck , Ahmed Majed H , Alsalihi Anam R
Published: April 2023

Background: obesity is an important cause of adverse health problems, including male infertility. Testosterone is essential for spermatogenesis and permits the release of mature sperms. In the absence of testosterone stimulation, spermatogenesis does not proceed beyond the meiosis stage. Aromatase expression is directly related to the degree of adiposity; it is dependent on cytokine stimulation and requires the presence of glucocorticoids, 17β-estradiol in the plasma of adult men is formed by aromatization convert testosterone and androstinedione to 17β-estradiol Apoptosis is an important process in the context of germ cells since they undergo both mitosis and meiosis, and this process is affected by interleukin 6and 2 (IL6 and IL2).Objectives: To assess the effect of body mass index on serum sex steroidal hormones, seminal antiapoptotic factor soluble fibroblast associated surface antigen (sFas) and inflammatory markers (IL6, IL-2), with conventional semen parameters in infertile men.Patients and methods: One hundred and six male partners of infertile couples were involved in the study. Height and weight of them were measured to calculate the body mass index (BMI). Serum testosterone and estradiol 2.were measured for all.Semen sample was taken after 2-7 days of abstinence. Conventional semen analysis was done for each sample according to the protocol of (WHO) 2010, after incubation and liquefaction period (30-60 min). Semen plasma was collected for analysis of interleukins (2 and 6) and sFAS .by specific kits Patients with severe oligospermia (below million sperm/ml) were excluded from the study. The rest (77) subjects were divided into three groups according to BMI (WHO, 2010) as follows: Normal (BMI < 25 kg/ m2) (n=24): Overweight (BMI ≥ 25 and < 30 kg/m2) (n=30): Obese (BMI > 30 kg/m2) (n=23).Results: The results showed a significant decrease in Testosterone level and Testosterone/E2 ratio in overweigh and obese subjects as compared to normal. The results of conventional semen analysis showed significant difference in pH and no. of round cell between the two groups. There was positive correlation between IL2 with sFAS in the two groups, and negative correlation of IL2 with total progressive cell and motility in both overweigh and obese groups. There was positive correlation of IL6 with no. of round cells in both studied groups.Conclusion: BMI affects Testosterone level and Testosterone/E2 ratio (they were significantly decreased in overweigh and obese patients). A positive correlation between IL2 and sFAS in obese patients as well as positive correlation of IL6 with round cells in obese patients indicate the role of apoptosis which is essential for normal fertility to remove abnormal and unwanted cells in ejaculate, in infertile overweight and obese patients.
Pharmacological treatment of obesity
Authors: Anglart Gabriela , Dominiak Katarzyna , Dettlaff Katarzyna
Published: April 2023

Nadwaga i otyłość są przyczynami wielu chorób, takich jak cukrzyca II typu oraz choroby sercowo-naczyniowe. Z każdym nadmiarowym kilogramem masy ciała zwiększa się także ryzyko zachorowania na nowotwory m.in.: przełyku, nerki i trzustki, raka wątrobowokomórkowego czy raka wpustu żołądka. W ostatnich dekadach obserwowany jest wzrost liczby osób dotkniętych otyłością. Z tego powodu problem ten nazywany jest epidemią otyłości. Epidemia ta dotyka nie tylko osób dorosłych, ale także coraz młodsze dzieci. Regularna aktywność fizyczna oraz zmiana nawyków żywieniowych są podstawą leczenia otyłości lub nadwagi. W przypadku, gdy nie osiąga się zamierzonych celów terapeutycznych, możliwe jest włączenie leczenia farmakologicznego. Grupa leków na otyłość w lecznictwie ulega znacznej zmianie na przestrzeni lat. Wiele leków o tym wskazaniu, wprowadzanych do lecznictwa w XX i XXI wieku, zostało wycofanych z powodu odkrytych poważnych działań niepożądanych. Dotyczyło to fenterminy, mazindolu, sibutraminy i rimonabantu.
Obecnie w Polsce do leczenia otyłości dostępne są cztery leki. Najstarszy z nich, orlistat, został wprowadzony do obrotu w roku 1998. Kombinacja naltreksonu z bupropionem oraz liraglutyd są dostępne od 2015 roku. Natomiast w 2021 roku zarejestrowano setmelanotyd, wykorzystywany jedynie w przypadku otyłości wynikającej z rzadkich chorób genetycznych. W niniejszym artykule dokonano przeglądu ich struktury chemicznej, mechanizmu działania, efektywności oraz działań niepożądanych. Ponadto opisano semaglutyd, drugi po liraglutydzie lek z grupy analogów hormonu inkretynowego, glukagonopodobnego peptydu 1. W Polsce jest on zarejestrowany tylko jako lek przeciwcukrzycowy, lecz w Stanach Zjednoczonych od roku 2021 stosowany jest w otyłości. Obecność tego leku w obrocie i obiecujące wyniki badań klinicznych powodują, że także w Polsce jest zapisywany poza wskazaniami rejestracyjnymi do leczenia otyłości.
Nowe terapie leczenia otyłości dają nadzieję na skuteczne i mniej ryzykowne rozwiązanie problemu niż chirurgia bariatryczna. Należy pamiętać, że dopiero połączenie zdrowej diety, ćwiczeń fizycznych i leczenia farmakologicznego daje najlepsze i najtrwalsze efekty w leczeniu otyłości.
Variation of Newly Diagnosed Type 1 Diabetes Mellitus Cases During Covid-19 Pandemic: A Review
Authors:   Pediatric Endocrinologist, Diabetes Reaserch Center of Mazandaran, Mazandaran University of Medical Sciences, Sari, Iran., Zamanfar Daniel , Ghazaiean Mobin ,   Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran., Zahedi Mohammad ,   Student Research Committee, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
Published: April 2023

Background Type 1 diabetes mellitus (T1DM) is one of the chronic diseases that timely and correct management affects the outcome of these patients. COVID-19 is an acute respiratory infection that has created a disproportionate situation for individuals and healthcare systems. The resulting pandemic is associated with delayed presentation of patients as well as increased frequency and severity of acute complications. Objectives This review study aims to investigate the incidence, initial presentation, frequency, and severity of diabetic ketoacidosis (DKA) as well as changes in demographic findings, such as age and sex in newly diagnosed T1DM children and adolescents during the COVID-19 pandemic. Methods The search was conducted in different databases, using the keywords: T1DM, COVID-19, pediatrics, and incidence to find the related articles published in English from December 31, 2019, to March 3, 2022. Results There is no clear evidence for increase in the incidence of T1DM and the frequency and severity of DKA in female and younger people during the pandemic compared to the pre-pandemic period. Further studies with larger sample sizes are needed to better understand the role of pandemic on disease incidence and acute complications. Conclusions: To reduce the incidence of DKA and speed up the diagnosis of T1DM during the pandemic, people should be informed about their symptoms.
Psychological Impact of COVID-19 on Children and Adolescents: A Narrative Review
Authors:   Children Growth Disorder Research Center, ShahidSadoughi University of Medical Sciences, Yazd, Iran., Nafei Zahra , Samadzadeh Golnaz ,   Student Research Committee, Faculty of medicine, ShahidSadoughi University of Medical Sciences, Yazd, Iran., Ordooei Mahtab ,   Children Growth Disorder Research Center, ShahidSadoughi University of Medical Sciences, Yazd, Iran., Vaghefi Marzie ,   Children Growth Disorder Research Center, ShahidSadoughi University of Medical Sciences, Yazd, Iran.
Published: April 2023

Background: With the global spread of COVID-19, many families have experienced the physical or psychological effects of the disease, which has had a profound impact on children. Objectives: Given that most studies have assessed the effects of COVID-19 on physical health, this study reviews the psychological and psychosomatic aspects of the disease and possible solutions to improve the condition of children and adolescents regardless of physical problems and complications of COVID-19. Methods: The data employed in our narrative review were searched for English documents published between 2019 and 2022 in EMBASE, Web of Science, Scopus, Google Scholar, and PubMed databases. Keywords included Mental health, Grief, Anxiety, depression, Children, and COVID-19. After screening the abstracts, the full text of 70 related studies was reviewed, and finally, 52 relevant surveys were selected. Results: Among the most important issues are the irreparable effects of losing a parent or the death of a loved one due to this disease (loss and grief) and a wide range of other disorders, such as feelings of fear, anxiety, depression, sleep problems, and post-traumatic stress disorder. However, the destructive effects of prolonged school closures and turning to social media without parental supervision and adequate infrastructure for children cannot be ignored. Conclusions: Children’s reactions to stress are different, such as overdependence, anxiety, withdrawal, anger, bedwetting, etc. Long-term quarantine and its consequences have increased anxiety and depression, sleep disorders, and nutritional problems in children and adolescents. Therefore, children need a safe and supportive environment, guidance, and help to express their fear and sadness.
Mp-MR ile Prostat Kanseri Şüphesi Bulunan Hastalarda, MR-TRUS Füzyon Biyopsi ve Kognitif Füzyon Biyopsi Tekniklerinin Karşılaştırılması
Authors: ERDEMLİ GÜRSEL Başak , ÖNGEN Gökhan , TOPAL Naile Bolca , TURAN Levent , YAVAŞCAOĞLU İsmet , SAVCI Gürsel
Published: April 2023

Bu çalışmada, Multiparametrik Manyetik Rezonans (mp-MR) tetkikinde PIRADS 3 (Prostat Görüntüleme Raporlama ve Bilgi Sistemi) ve üzeri lezyonu bulunan hastalarda MR- Transrektal Ultrasonografi (MR-TRUS) eşliğinde füzyon biyopsi ve kognitif Füzyon (KF) biyopsi tekniklerinin prostat kanseri saptamadaki etkinliklerinin karşılaştırılması amaçlanmıştır. Kliniğimizde 2017-2022 yılları arasında biyopsi öncesi yapılmış mp-MR tetkiklerinde PIRADS 3 ve üzeri lezyonu bulunan, PSA değeri 2-20 ng/ml arasında olan, daha önce hiç prostat biyopsisi yapılmamış ve mp-MR tetkiki sonrası ilk 6 ay içerisinde 48 MR-TRUS, 48 KF füzyon biyopsisi yapılmış 96 hasta seçildi. Hasta yaşı, PSA değeri, prostat volümü, lezyonların boyutu ve PIRADS skoru gibi parametreler değerlendirildi. Gruplar arasında demografik verilerde, PSA değerleri, prostat volümleri ve lezyonların boyut ve PIRADS skorlarında anlamlı farklılık saptanmadı (p>0.05). Kognitif füzyon yapılan grupta herhangi bir lokalizasyonda kanser yakalama oranı %41,7 (20/48 hasta), MR-TRUS füzyon biyopsi yapılan grupta %39,6 (19/48 hasta) bulundu. İki grup arasında istatistiksel olarak anlamlı farklılık saptanmadı (p=0,835). Hedefli biyopsi sonuçlarında ise kanser saptama oranları KF grubunda %85 (17/20 hasta), MR-TRUS grubunda %73,7 (14/19 hasta) bulundu. Bu iki grup arasında da anlamlı farklılık izlenmedi (p=0,518). Sonuç olarak, kanser yakalama başarısının benzer olması, uygulamasının daha kolay ve maliyetinin daha düşük olması nedeniyle KF biyopsi tekniği MR-füzyon biyopsisine tercih edilebilir.
The Public Sector's Digital Skills Gap in Indonesia: The Challenges and Opportunities
Authors: Silitonga Mala Sondang
Published: April 2023

This study aims to investigate how far civil servants' digital literacy contributes to the public sector's digital transformation by examining various factors of sharing knowledge concept, such as willingness to learn, willingness to share, and digital transformation. This study employs a mixed-methods approach. The quantitative approach relies on an online survey of 125 local civil servants. A qualitative approach was used with in-depth interviews and focus group discussions with civil servants in Jakarta, West Java, and Yogyakarta provinces. The data gathered was then analyzed using the regression technique. The results of the study show that willingness to learn and willingness to share have no effect on the impact of digital transformation. This is supported by qualitative data, which shows that regulation is the most important factor, followed by increasing efforts to equip ASN in all generations with stronger digital skills.

Keywords: Skill Gap, Digital Transformation literacy, Willingness to Share, Willingness to Learn
Public Transport Use on Trip Chains: Exploring Various Mode Choice Determinants
Authors: Lunke Erik Bjørnson , Engebretsen Øystein
Published: April 2023

The purpose of the study is to explore the relative influence of different measures of accessibility, public transport quality and local density on trip chain mode choice. This study uses data from the National Travel Survey in Norway and develops a logistic regression model on the choice between public transport and car on daily trip chains. Results show that the most important factors in explaining the use of public transport are 1) the travel time competitiveness of public transport versus the car, 2) parking restrictions, 3) centrality of trip chain destinations, and 4) waiting time between departures.
Cancer Conversations Among Children With Cancer
Authors: Pathmalingam Tharanni
Published: April 2023

 Self-disclosure is a psychosocial process in which children carefully decide who, what, and how they tell others about their illness. Unfortunately, there is very little known about how children disclose their cancer diagnosis to their peers. For this reason, this study utilized a qualitative secondary analysis approach to investigate whether and how children disclose their illness to peers at camp. A thematic analysis was undertaken to analyze 21 interviews completed by children who experienced cancer and were from two summer residential camps in Ontario. This resulted in four themes including talking about cancer, thinking about cancer, attitude towards illness, and social environment and relationships. The findings affirm that illness disclosure is extremely complex and has several contributing factors. Further research in the area of disclosure among children with cancer is encouraged, as it can assist in the development of support and interventions for children engaging in numerous types of disclosure.  
Geographic, seasonal and ontogenetic variations of δ15N and δ13C of Japanese sardine explained by baseline variations and diverse fish movements
Authors: Sakamoto Tatsuya , Kodama Taketoshi , Horii Sachiko , Takahashi Kazutaka , Tawa Atsushi , Tanaka Yosuke , Ohshimo Seiji
Published: April 2023

Understanding and predicting variability in the stable isotope ratios of nitrogen and carbon (δ15N and δ13C, respectively) of small pelagic fish is crucial to enable isotopic studies of a variety of marine predators that feed on them. However, because the isotope ratios reflect plastic feeding habits and fish migration in addition to baseline variation, their predictions require a mechanistic understanding of how each factor contributes. Here, we investigated the habitat-wide variability of δ15N and δ13C of the Japanese sardine Sardinops melanostictus in the western North Pacific and its marginal seas (the East China Sea and the Sea of Japan). By combining this with the archived particulate organic matter (POM) dataset as a baseline, we aimed to understand how ecological processes and baseline fluctuations affect isotope ratios of the sardine. Both δ15N and δ13C of sardine showed significant geographical and seasonal trends, with higher values in southern nearshore areas, including the Seto Inland Sea, intermediate values in marginal seas and lower values in Pacific offshore areas. As the variations were largely consistent with the geographic and temporally integrated seasonal trends of isotope ratios of POM, respectively, the baseline variations are the main determinant of sardine isotope composition. The trophic levels of sardine are therefore not significantly different between regions, with possible minor increases in the southern nearshore area. Adults showed less geographic variation than larvae and juveniles, likely due to slower turnover periods and wider migration ranges. Although larval and juvenile isotope ratios in marginal seas mostly reflected the local baseline, those in the Pacific offshore often reflected the baseline in the neighbouring southern region, suggesting contrasting juvenile movements between regions. Our results suggest that the δ15N and δ13C of Japanese sardine strongly reflect baseline variations, but can also be influenced by life-stage- and region-dependent fish movements, thereby demonstrating both the possibility and difficulty of mechanistically modelling the isoscapes of lower trophic level species.
Protocol: How can people with social care needs be supported through processes of digital care navigation to access remote primary care? A multi-site case study in UK general practice of remote care as the ‘new normal’.
Authors: Hughes Gemma , Rybczynska-Bunt Sarah , Shasha'h Sara , Greene Sarah , Shaw Sara , Greenhalgh Trisha
Published: April 2023

Background: Care navigation refers to support for patients accessing primary care and other related services. The expansion of digitally enabled care in the UK since the coronavirus disease 2019 (COVID-19) pandemic has led to a greater need for digital care navigation: supporting people to access primary care digitally and, if necessary, to help them find alternative non-digital routes of access. Support to patients with social care needs (including but not limited to those who are homeless and insecurely housed, living in residential care and supported by domiciliary carers) increasingly involves work to navigate primary care provided remotely and accessed digitally. There is little knowledge about how this work is being done. 

Methods: Care Navigation involves embedded researchers identifying digital care navigation for patients accessing services in 11 GP practices recruited to a linked study of remote primary care (Remote care as the ‘new normal?’). Digital care navigation will be studied through go-along (in-person or remote) interviews with a sample of 20 people offering formal (paid or voluntary) support, 6 national and regional stakeholders who plan, commission or provide digital care navigation and a focus group with 12 social prescribers engaged in digital care navigation. A co-design workshop with people working in, or commissioning, social care settings will consider how findings can inform improved digital care navigation, for example through the development of resources or guidance for care navigators.

Results (anticipated): Findings are anticipated to include evidence of how digital care navigation is practised, the work that is done to support patients in accessing remote primary care, and how this work is shaped by material resources and variations in the configuration of services and infrastructure.

Conclusions: New explanations of the work needed to navigate digital care will inform policy and service developments aimed at helping patients benefit from remote primary care.
Who will save the world? –from the missing hero to the index of Captain Planet
Authors: Nagy Ádám , Fekete Mariann , Tóth Péter
Published: April 2023

Captain Planet is a superhero, who is the main character of the animated series
having the same title. The focus is on environmental protection and diverse social
problems; the only weak point of the Captain is polluted environment which noticeably
weakens him. Each episode of the animated series deals with environmental issues like
deforestation, air or water pollution, overpopulation.
Large-scale youth research has been conducted in Hungary every four year since 2000. The
representative sample on age, gender, education, type of settlement, place of residence
(district / city) among 15-29 year olds are used to learn about the life situation of
young people, to follow their lifestyle changes and (in theory) to prepare (typically
public policy) decision-making. The most important events and specific problems of
Hungarian youngsters aged 15-29. 8000 youngsters were examined in 2020 as well,  
We use the data of wave the 2020 large scale Hungarian Youth Research for mapping the
„Hungarian Captain Planet”. We found, that H. Captain Planet does not belong to
climate-fighter Generation Z, but youngsters aged 25-29 who are highly educated, who
have a stable financial situation, who are not inactive, that is they either study or
work (one third of youngsters belong to this group (32%)). It may be a commonplace,
however, it was managed to prove this commonplace scientifically.
CARACTERIZAÇÃO FÍSICO-QUÍMICA DE FRUTOS DE ABIU (Pouteria caimito) COLETADOS EM QUINTAIS AGROFLORESTAIS DE RORAIMA
Authors: Soares Marques Carolina , Da Silva Lelisângela Carvalho , Flores Andréia Silva , Guimarães Pedro Vitor Pereira , Chagas Edvan Alves
Published: April 2023

O conhecimento sobre a diversidade de Pouteria é importante para promover o incentivo do cultivo como fonte de renda e nutricional. Objetivou-se caracterizar físico-quimicamente frutos e sementes de Pouteria caimito (Ruiz & Pavon.) Radlk coletados em quintais agroflorestais em duas regiões de Roraima. Os frutos foram coletados nos municípios de Boa Vista e Rorainópolis, para a obtenção dos dados morfométricos e análises físico-químicas. Os frutos estudados apresentam rendimento e qualidade satisfatória para consumo e processamento agroindustrial. Os valores das variáveis físico-químicas indicam que os frutos e sementes de abiu apresentam variabilidade em suas características, o que pode estar relacionada a fatores genéticos e/ou as condições edafoclimáticas. Os quintais estudados apresentam características relacionadas aos princípios da agroecologia, como a diversidade de espécies sendo áreas com potencial para a produção de alimentos que contribuem para segurança alimentar e manutenção da biodiversidade.
Tele-Medical Technologies Usage in Medical Treatment Organizations of Federal Medical and Biological Agency
Authors:   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation, Kilnik A.I. , Bagaev G.A. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation, Kuzin E.A. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation
Published: April 2023

Summary. The main issues of provision of medical help and treatment with usage of tele-medical technologies (TMT) were considered, including victims in emergency situations (ES), in medical treatment organizations (MTO) of Federal Medical and Biological Agency (FMBA of Russia). Noticed that an experience of conducting of tele-medical consultations (TMC) which was made in All-Russian Center of Disaster Medicine “Zashchita” (was handed over to FMBA of Russia in 2020) allowed to increase number of MTO of FMBA of Russia which are participated in conducting of medical consultation by the scheme “doctor-doctor”. Underlined that 2020-2021 became the key years for development of tele-medical consultations system of FMBA of Russia because of a necessity of: – organization and conducting of urgent and emergency TMC for patient with diagnosed COVID-19 and pneumonia; – development and putting into service of centralized subsystem “Telemedical consultations” of Unified departmental medical informational-analytic system of FMBA of Russia. In addition, those years Federal State Budget Organization “Science medical researching center of otorhinolaryngology” (SMRCO) of FMBA of Russia was involved in federal project “Development of network of national medical researching centers” on the profile “Otorhinolaryngology” which implies a conducting of tele-medical consultations science-practical events (lectures, seminars) for “anchor” MTO of subjects of the Russian Federation on the profile of curation. A conclusion was drown: usage of Federal tele-medical system allowed medical specialists of FMBA of Russia and Ministry of Health of Russia, MTO of other federal departments of executive power to make distance interaction between each other during a provision of medical treatment with usage of tele-medical technologies and to add these technologies to clinical practice.
The Role of Urgent Medical Treatment Department in Conditions of a Massive Influx of Technogenic Emergencies Victims
Authors:   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Tsebrovskaya E.A. , Teplov V.M. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Klyukovkin K.S. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Prasol D.M. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Kolomoytsev V.V. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Burykina V.V. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Arkhangelskiy N.D. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Ikhaev A.B. ,   Republican Ambulance Station, Groznyy, Russian Federation, Bagnenko S.F. ,   Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Kasymova O.A. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation
Published: April 2023

Summary. Investigation purpose – a planning of stationary department of urgent medical treatment (SDUMT) work in conditions of massive influx of technogenic emergencies (ES) victims. Methods and materials of the investigation. To make the virtual models of (SDUMT) the Flexsim HealthCare software was chosen. The software allows to conduct a processive modeling of predictable work. A work of two stationary urgent medical treatment departments was recreated. The first was SDUMT of university clinic of the First Saint-Petersburg state medical university (FSPAMU) named after academic I.P. Pavlov of Ministry of Health of Russia (model-1) with average (23±2 patients per day) patient influx. The second was SDUMT of city urgent medical treatment hospital №25 of the city of Volgograd (model 2) with average (145±3 patients per day) patient influx. In addition, a retrospective analysis of technogenic ES happened in 45 Russian subjects in 2017-2022 was conducted. A prognosis of specified SDUMT work in conditions of massive emergency victims influx was planned to conduct basing on the up written analysis. Investigation results and their analysis. As a result of the experiments an optimal SDUMT staff was defined. The role of this staff in conditions of massive technogenic emergency victims influx was assessed.
Psychophysiology of Inattention and Fatigue in Car Drivers Distracted for Electronic Devices
Authors:   Perm State University named academician E.A.Wagner, Perm, Russian Federation, Nogovitsyna E.M. , Shilov S.Yu. ,   Perm State University named academician E.A.Wagner, Perm, Russian Federation,   Branch of the Perm Federal Research Center “Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences”, Perm, Russian Federation
Published: April 2023

Summary. Investigation purposes – a researching of psychophysiological features and an opportunity of inattention and fatigue prevention in car drivers distracted for electronic devices. Materials and methods of the investigation. An analysis of 45 publications in Russian and English found using Cyberleninka, PubMed, Elibrary, ScienceDirect data bases was conducted. Investigation results and their analysis A distraction of car drivers for electronic devices make them instant fatigued because of attempts of combining of driving and with unrelated to it actions. A distraction for mobile phone can stimuli all forms of attention looses – auditory, visual, biomechanical, cognitive. A conclusion was made that nowadays algorithms for attention tiredness / distraction analysis in car drivers are not distributed enough.
Modern Approaches to the First Aid Provision in Cases of Poisonings and Methods of the Provision Improvement
Authors:   Medical Academy named after S.I. Georgievskiy of V.I. Vernadskiy Crimean Federal University, Simferopol, Russian Federation, Birkun A.A. ,   Crimean Republican Center for Disaster Medicine and Emergency Medical Care, Simferopol, Russian Federation, Dezhurnyy L.I. ,   Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Moscow, Russian Federation,   Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Published: April 2023

Summary. Investigation purposes – an analysis if modern approaches to the first aid (FA) provision in cases of poisoning; a researching of normative legal regulation of FA provision in the Russian Federation; a determination of measures of first aid provision improvement; creation of the project of universal algorithm of dispatching support of first aid in cases of poisonings. Material and methods of the investigation. Investigation materials – national and international publications about a first aid provision in cases of poisonings; international and national recommendations which characterize modern approaches to the FA provision in cases of poisonings; complexes of practical recommendations/protocols for ambulance dispatchers, including instructions for distance advising of injury witnesses on the provision of FA in cases of poisonings. Investigation results and their analysis. A review of modern principles and approaches to the FA provision is cases of poisonings based on the analysis of national and international FA recommendations was presented; Features of normative legal regulation of FA provision in cases of poisonings in the Russian Federation were analyzed; ways of FA provision effectivity improvement were determined. A practice of distance phone advising by emergency service dispatchers of an unskilled injury witnesses on the provision of FA is discussed as a perspective direction of improvement of FA provision in cases of poisonings; a project if universal Russian language algorithm for dispatcher support of FA in cases of poisonings was presented and now is offered for further discussion.