bluuebunny/crossref_metadata_2025 huggingface dataset:
Politics of Cemetery: Religious Minority in Local Indonesia
Authors: Ekaputri Adethia Septiyani , Sugiarto Bowo
Published: March 2022

In post-authoritarian Indonesia, although the position of followers of belief (kepercayaan) before the state has relatively positive progress, some still face problems related to their religious identity. One of the followers of belief groups that still receive religious discrimination is the Sapta Darma community in Brebes, Central Java, Indonesia. For example, the followers of Sapta Darma in this region face problems of the availability of cemetery for their deceased members, while just like some other religions; a burial ground is an important part of their religious ritual and identity. This article attempts to explain what restrictions prevent the Sapta Darma community from obtaining cemetery land for their members and what the Sapta Darma community has conducted to settle the problem. This article is based on qualitative research that was conducted in Brebes. This article shows that the availability of Public Cemetery (TPU) and some people’s acceptance of this community serve as the main restriction for the Sapta Darma community to fulfill their need for cemetery land. To settle this problem, they have made some attempts, including seeking the state’s recognition and solution independently.
Isu Perbatasan dan Politik Kesejahteraan: Kebijakan Pembangunan Terminal Barang Internasional Entikong
Authors: Elyta Elyta
Published: March 2022

Pembangunan negara berkaitan erat dengan peran negara termasuk pada pembangunan terminal barang internasional yang bertujuan untuk meningkatkan kesejahteraan masyarakatnya di kawasan perbatasan Entikong Indonesia. Berbagai permasalahan di PLBN Entikong yang disinyalir rawan barang impor ilegal yang tidak terkontrol menunjukan bahwa peran negara sangat diperlukan dalam keberhasilan pembangunan Terminal Barang Internasional. Pada penelitian kali ini memfokuskan pada peran negara pada pembangunan Terminal Barang Internasional di Entikong menuju negara kesejahteraan. Penelitian tentang peran dari negara dalam pembangunan Terminal Barang Internasional Entikong menggunakan analisa kualitatif. Hasil penelitian menemukan peran dari negara dalam pembangunan Terminal Barang Internasional Entikong ialah sebagai fasilitator yaitu fasilitator pengkajian; katalisator, yaitu katalisator pemerataan ekonomi dan katalisator perlindungan keamanan; dan regulator, yaitu dalam mengatur regulasi dalam negeri dan regulasi luar negeri.
Systematic mitigation of gain scheduling induced windup phenomena
Authors: Kefferpütz Klaus , Bartenschlager Benedikt , Auenmüller Christoph , Seitz Sebastian
Published: March 2022

In this paper, we discuss the systematic design of gain scheduling controllers for nonlinear systems. We discuss control signal blending induced windup phenomena and employ an extended Model-Recovery Anti-Windup (MRAW) scheme to mitigate them. Combining control signal blending with MRAW allows to build gain scheduling controllers without imposing the common slow variation assumption regarding the scheduling vectors. In addition, the approach offers a higher flexibility in the choice of the sub-controllers compared to classical approaches and convex optimization allows for a very efficient design of the anti-windup networks.
Data fusion for automated driving: An introduction
Authors: Schreier Matthias
Published: March 2022

Data fusion is one of the key ingredients of Advanced Driver Assistance Systems (ADAS) and Automated Driving Systems (ADS). The article provides an introduction into the field by highlighting different possible data fusion categorizations and architectures alongside pros and cons. Benefits, limitations, and pitfalls of exemplary data fusion systems are presented, and the consequences of specific design choices discussed.
Fahrplanoptimierung von Windenergieanlagen ohne feste Einspeisevergütung
Authors: Fischer Boris
Published: March 2022

Die steigende Komplexität der Randbedingungen für den Betrieb von Windenergieanlagen stellt deren herkömmliche Betriebsstrategie in Frage. Erfolgt die Vergütung über Erlöse an der Strombörse, ist es sinnvoll, beim Betrieb auf die Schwankungen der Preise zu reagieren. Wie sollten derartige Reaktionen gestaltet werden? Welche Auswirkungen hat dies auf die Rentabilität der Windparkprojekte aus Betreibersicht? Mit Hilfe einer Fallstudie bewertet der vorliegende Beitrag anhand ökonomischer Kriterien die gezielte Zu- und Abschaltung der Anlagen in Abhängigkeit von Windverhältnissen und Strompreis. Die Ergebnisse der Fallstudie zeigen, dass es sinnvoll sein kann, die Anlagen in wirtschaftlich ungünstigen Situation abzuschalten. Entgangene niedrige Erlöse bei schadensintensiven Windverhältnissen werden durch die Erlöse über eine deutlich verlängerte Lebensdauer der Anlagen wiedergewonnen und die Retabilität des Projektes steigt erheblich.
Adopting attention-mechanisms for Neural Logic Rule Layers
Authors: Reimann Jan Niclas , Schwung Andreas , Ding Steven X.
Published: March 2022

In previous works we discovered that rule-based systems severely suffer in performance when increasing the number of rules. In order to increase the amount of possible boolean relations while keeping the number of rules fixed, we employ ideas from well known Spatial Transformer Systems and Self-Attention Networks: here, our learned rules are not static but are dynamically adjusted to fit the input data by training a separate rule-prediction system, which is predicting parameter matrices used in Neural Logic Rule Layers. We show, that these networks, termed Adaptive Neural Logic Rule Layers, outperform their static counterpart both in terms of final performance, as well as training stability and excitability during early stages of training.
MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements
Authors: Ioannou Charalampia , Ragia Georgia , Balgkouranidou Ioanna , Xenidis Nikolaos , Amarantidis Kyriakos , Koukaki Triantafyllia , Biziota Eirini , Kakolyris Stylianos , Manolopoulos Vangelis G.
Published: March 2022

Objectives

The fluoropyrimidine derivatives 5-Fluorouracil and Capecitabine are widely used for the treatment of solid tumors. Fluoropyrimidine metabolism involves a cascade of different enzymes, including MTHFR enzyme. MTHFR c.665C>T polymorphism, leading to decreased MTHFR activity, is a potential pharmacogenomic marker for fluoropyrimidine drug response. The aim of the present study was to analyze the association of MTHFR c.665C>T polymorphism with fluoropyrimidine response in terms of therapy induced adverse events (AEs), requirement of dose reduction and delayed drug administration or therapy discontinuation.

Methods

The study group consisted of 313 fluoropyrimidine-treated cancer patients. PCR-RFLP was used to analyze MTHFR c.665C>T polymorphism.

Results

In female patients, MTHFR c.665 CT and TT genotypes were associated with dose reduction (p=0.029). In gender stratification, regression analysis adjusted for age of disease onset, body surface area and AE incidence, showed that MTHFR CT and TT genotypes increased both need for fluoropyrimidine dose reduction (OR 5.050, 95% CI 1.346–18.948, p=0.016) and percentage of dose reduction (β=3.318, 95% C.I. 1.056–5.580, p=0.004) in female patients. Such differences were not present in male patients. No other associations were found.

Conclusions

MTHFR c.665C>T polymorphism was associated with fluoropyrimidine dose reduction in female cancer patients. This gender*MTHFR interaction merits further investigation.
What is “Language Making”?
Authors: Krämer Philipp , Vogl Ulrike , Kolehmainen Leena
Published: March 2022

This article introduces a new concept called “Language Making”. The term covers all kinds of processes in which speakers or non-speakers collectively conceptualize linguistic entities. Such processes are usually perpetual, they operate based on language ideologies and attitudes, and they bring about functional and structural norms which determine the boundaries of linguistic entities such as languages, dialects or varieties. The article discusses the significance of standardization, language policy and planning, and of stakeholders and agency for processes of Language Making. Raising the question as to why a new concept is needed in the first place, the article concludes with a demarcation of Language Making from opposite processes which may be called “un-Making” of Languages.
The family of random attractors for nonautonomous stochastic higher-order Kirchhoff equations with variable coefficients
Authors: Lv Penghui , Lin Guoguang , Sun Yuting
Published: March 2022

In this paper, the stochastic asymptotic behavior of the nonautonomous stochastic higher-order Kirchhoff equation with variable coefficients is studied. By using the Galerkin method, the solution of this kind of equation is obtained, and stochastic dynamical system under this kind of equation is obtained; by using the uniform estimation, the existence of the family of

D

k

{{\mathcal{D}}}_{k}

-absorbing sets of the stochastic dynamical system

Φ

k

{\Phi }_{k}

is obtained, and the asymptotic compactness of

Φ

k

{\Phi }_{k}

is proved by the decomposition method. Finally, the

D

k

{{\mathcal{D}}}_{k}

-stochastic attractor family of the stochastic dynamical system

Φ

k

{\Phi }_{k}

in

V

m
+
k

(

Ω

)

×

V

k

(

Ω

)

{V}_{m+k}\left(\Omega )\times {V}_{k}\left(\Omega )

is obtained.
La lengua como elemento valorativo dentro de una posible gestión del discurso en organizaciones mediáticas tradicionales. Apuntes desde la praxis periodística / Language as an assessing element in possible speech management in traditional media
Authors: Vidal Valdés José Ramón , Nápoles Fernández Lourdes María , Moreno Fernández Yoelvis Lázaro
Published: March 2022

Este trabajo pone énfasis en la lengua como instrumento esencial en las prácticas de la producción discursiva mediática. Se recogen los anclajes teóricos fundamentales en el itinerario inicial de una investigación doctoral que se aproxima, desde una perspectiva comunicológica, a la lengua como producto, actividad e instancia de significación cultural, al tiempo que se percibe como elemento de valoración dentro de una posible gestión del discurso en organizaciones periodísticas tradicionales. Se identifican las principales convergencias que permiten el diálogo entre comunicación y lengua, se brindan determinadas coordenadas relacionales entre la lengua y el discurso, y se provee un marco teórico propicio para la comprensión de los medios como organizaciones productoras de discurso, en cuya gestión dentro de las dinámicas productivas mediáticas la lengua puede desempeñarse como un aspecto de valoración esencial. Se identifican las claves para tal fin desde el área práctica a partir de un acercamiento exploratorio a lo que acontece en la praxis productiva del periódico Juventud Rebelde (JR), uno de los medios de mayor tradición profesional en la prensa impresa cubana, para lo cual se utilizaron varios métodos y técnicas: método bibliográfico–documental, observación participante, entrevistas semiestructuradas y grupos de discusión.
5 razones para una publicidad ética
Authors: Pellicer Jordá María Teresa
Published: March 2022

En el artículo que presentamos a continuación, ofrecemos cinco grandes argumentos que avalan la necesidad del cumplimiento ético en la publicidad. Éste les proporcionará un mayor éxito, sobre todo a nivel de imagen de marca, algo muy necesario si tenemos en cuenta la mala imagen que suelen tener los ciudadanos de la publicidad
Las redes sociales online en España 2012-2016: mucho más que una herramienta comunicativa / Online social networks in Spain 2012-2016: much more than communication tools
Authors: Vázquez Chas Loreto
Published: March 2022

En la actualidad, las redes sociales online se han convertido en parte de la vida diaria de millones de personas en el mundo y su uso no queda limitado al terreno personal, si no que también se convirtieron en herramientas de participación en la sociedad y en nuevos medios de comunicación, lo que tiene repercusiones sobre el capital social de los individuos, ya que, como se verá a lo largo de este trabajo, lo complementa. Al mismo tiempo que se estudian los datos correspondientes, referentes a España, se perfila la evolución de dichas redes con respecto a los ítems mencionados en el periodo de tiempo que comprende desde el año 2012 al año 2016, para llegar a la conclusión de que si bien el uso que se hace de las redes sociales online en la actualidad no se ha incrementado con respecto a los datos de 2012, sí que continúan mostrando que tienen capacidad para complementar al capital social en la actualidad.
Influencia de la internacionalización de la empresa en la implementación de los 10 principios del pacto mundial de Naciones Unidas / Influence of internationalization of firms on implementation of United Nations global compact 10 principles
Authors: Alba Ruiz-Morales Carmen
Published: March 2022

El Pacto Mundial de Naciones Unidas es una de las mayores iniciativas empresariales internacionales de responsabilidad social corporativa. La red española de la iniciativa, es la red local con mayor número de firmantes a nivel mundial. A su vez, el proceso de internacionalización de la empresa española ha ido en aumento en los últimos años provocando que haya un gran número de compañías españolas operando en mercados internacionales. Estudios previos han planteado la relación entre el fenómeno de la internacionalización y la responsabilidad social corporativa de las empresas. En este trabajo se pretende analizar el avance en la gestión de los 10 Principios del Pacto Mundial, según el Modelo de Gestión desarrollado por el Pacto Mundial, y la influencia con el proceso de internacionalización de las empresas.
La pintura de historia: ¿El presente en el pasado o el pasado en el presente? / The painting of history: The present in the past or the past in the present?
Authors: Ziegler María Magdalena
Published: March 2022

A través de la revisión de cinco los casos particulares de los artistas Jacques-Louis David, Benjamin West, Francisco de Goya y Lucientes, Eugene Delacroix y John Trumbull, se demuestra como la pintura de corte histórico desde finales del siglo XVIII presenta una re-interpretación del significado de la historia y los hechos del pasado en su respectivo presente. Aunque la pintura de historia no es un género nuevo para el final del siglo XVIII, sí tenía unos claros lineamientos muy respetados por los círculos académicos en Occidente. La novedad radica en que desde la pintura se aborda una nueva visión de la historia en sintonía con las necesidades del presente. En este sentido, asumiendo cada una de las obras analizadas como la solución a un problema, se descifra a la obra misma en tanto aporte solvente.
La evocación del Old South en las adaptaciones cinematográficas de Tennessee Williams: el espacio como elemento narrativo / Evocation of the Old South in film adaptations of Tennessee Williams: the space as a narrative element
Authors: Durán Manso Valeriano
Published: March 2022

El sur de Estados Unidos tiene un papel determinante en la obra literaria del dramaturgo norteamericano Tennessee Williams. Este universo, que está centrado en la principal ciudad de Louisiana, Nueva Orleans, y en la región del Delta del Mississippi, cuenta con una importante representación cinematográfica gracias a las adaptaciones de las principales obras del escritor, realizadas entre 1950 y 1968. Así, el espacio sureño tiene un notable protagonismo en estas películas, y en algunos casos adquiere el carácter de personaje, debido a su relevante peso narrativo y a la constante evocación que los seres de ficción hacen de él. Con los objetivos de poner en valor el Old South como espacio poético y romántico en el cine americano clásico, reflexionar sobre la relación de Williams con su lugar de origen, y realizar una aproximación a la representación del universo sureño en sus principales adaptaciones cinematográficas, se intenta reflejar cómo el sur influye en la construcción de los temas y personajes del dramaturgo. En este sentido, películas como Un tranvía llamado deseo, Baby Doll, La gata sobre el tejado de zinc, De repente… el último verano o Dulce pájaro  de juventud, entre otras destacadas, comparten un mismo ámbito a pesar de desarrollarse en diferentes lugares meridionales de Estados Unidos. Desde estas consideraciones, este trabajo pretende reflexionar sobre cómo el sur heredero del Old South se erige como un elemento narrativo que determina la evolución dramática de las adaptaciones cinematográficas de Tennessee Williams.
A Corticothalamic Circuit Trades off Speed for Safety during Decision-Making under Motivational Conflict
Authors: Choi Eun A. , Husić Medina , Millan E. Zayra , Gilchrist Sophia , Power John M. , Jean-Richard dit Bressel Philip , McNally Gavan P.
Published: March 2022

Decisions to act while pursuing goals in the presence of danger must be made quickly but safely. Premature decisions risk injury or death, whereas postponing decisions risk goal loss. Here we show how mice resolve these competing demands. Using microstructural behavioral analyses, we identified the spatiotemporal dynamics of approach–avoidance decisions under motivational conflict in male mice. Then we used cognitive modeling to show that these dynamics reflect the speeded decision-making mechanisms used by humans and nonhuman primates, with mice trading off decision speed for safety of choice when danger loomed. Using calcium imaging in paraventricular thalamus and optogenetic inhibition of the prelimbic cortex to paraventricular thalamus pathway, we show that this speed-safety trade off occurs because increases in paraventricular thalamus activity increase decision caution, thereby increasing approach–avoid decision times in the presence of danger. Our findings demonstrate that a discrete brain circuit involving the paraventricular thalamus and its prefrontal input adjusts decision caution during motivational conflict, trading off decision speed for decision safety when danger is close. We identify the corticothalamic pathway as central to cognitive control during decision-making under conflict.

SIGNIFICANCE STATEMENTForaging animals balance the need to seek food and energy against the conflicting needs to avoid injury and predation. This competition is fundamental to survival but rarely has a stable, correct solution. Here we show that approach–avoid decisions under motivational conflict involve strategic adjustments in decision caution controlled via a top-down corticothalamic pathway from the prelimbic cortex to the paraventricular thalamus. We identify a novel corticothalamic mechanism for cognitive control that is applicable across a range of motivated behaviors and mark paraventricular thalamus and its prefrontal cortical input as targets to remediate the deficits in decision caution characteristic of unsafe and impulsive choices.
Precise and Pervasive Phasic Bursting in Locus Coeruleus during Maternal Behavior in Mice
Authors: Dvorkin Roman , Shea Stephen D.
Published: March 2022

The noradrenergic locus coeruleus (LC) mediates key aspects of arousal, memory, and cognition in structured tasks, but its contribution to naturalistic behavior remains unclear. LC activity is thought to multiplex distinct signals by superimposing sustained (“tonic”) firing patterns reflecting global brain states, such as arousal and anxiety, and rapidly fluctuating (“phasic”) bursts signaling discrete behaviorally significant events. Manipulations of the LC noradrenergic system broadly impair social behavior, but the temporal structure of LC firing and its relationship to social interaction is unknown. One possibility is that tonic firing may increase in the presence of social partners; it is also possible that phasic bursts may accompany specific social events. We used chronicin vivoelectrophysiology and fiber photometry to measure single-unit and population neural activity in LC of freely behaving mice during their interactions with pups. We find that pup retrieval elicits remarkably precise phasic activity in LC that cannot be attributed merely to sensory stimuli, motor activity, or reward. Correlation of LC activity with retrieval events shows that phasic events are most closely related to specific subsequent behaviors. The reliability and magnitude of phasic responses strongly suggest that these events are coordinated across LC and broadcast noradrenaline (NA) release throughout the brain. We also observed slow changes in tonic firing when females performed distinct maternal behaviors such as nest building and pup grooming. We therefore propose that LC signals state changes during sustained interactions and contributes to goal-directed action selection during social behavior with globally broadcast NA release.

SIGNIFICANCE STATEMENTLocus coeruleus (LC) releases noradrenaline (NA) brain wide, influencing many cognitive, emotional, and physiological processes. Multifunctionality of LC is maintained by multiplexing NA signaling via brief “phasic” patterns of bursting and slowly changing “tonic” firing. Manipulations of NA impair social behavior, yet the structure of LC activity with respect to specific social events is unknown. We measured LC activity in mice freely interacting with pups. We find that pup retrieval elicits precisely timed and pervasive phasic activation of LC that anticipates specific behaviors. We also found that LC neurons exhibited slow fluctuations in firing during sustained behaviors. We propose that LC simultaneously contributes to goal-directed social action selection with globally broadcast NA release and signals social state changes with increased tonic firing.
Descending Axonal Projections from the Inferior Colliculus Target Nearly All Excitatory and Inhibitory Cell Types of the Dorsal Cochlear Nucleus
Authors: Balmer Timothy S. , Trussell Laurence O.
Published: March 2022

The dorsal cochlear nucleus (DCN) integrates auditory nerve input with nonauditory sensory signals and is proposed to function in sound source localization and suppression of self-generated sounds. The DCN also integrates activity from descending auditory pathways, including a particularly large feedback projection from the inferior colliculus (IC), the main ascending target of the DCN. Understanding how these descending feedback signals are integrated into the DCN circuit and what role they play in hearing requires knowing the targeted DCN cell types and their postsynaptic responses. In order to explore these questions, neurons in the DCN that received descending synaptic input from the IC were labeled with a trans-synaptic viral approach in male and female mice, which allowed them to be targeted for whole-cell recording in acute brain slices. We tested their synaptic responses to optogenetic activation of the descending IC projection. Every cell type in the granule cell domain received monosynaptic, glutamatergic input from the IC, indicating that this region, considered an integrator of nonauditory sensory inputs, processes auditory input as well and may have complex and underappreciated roles in hearing. Additionally, we found that DCN cell types outside the granule cell regions also receive descending IC signals, including the principal projection neurons, as well as the neurons that inhibit them, leading to a circuit that may sharpen tuning through feedback excitation and lateral inhibition.

SIGNIFICANCE STATEMENTAuditory processing starts in the cochlea and ascends through the dorsal cochlear nucleus (DCN) to the inferior colliculus (IC) and beyond. Here, we investigated the feedback projection from IC to DCN, whose synaptic targets and roles in auditory processing are unclear. We found that all cell types in the granule cell regions, which process multisensory feedback, also process this descending auditory feedback. Surprisingly, all except one cell type in the entire DCN receive IC input. The IC-DCN projection may therefore modulate the multisensory pathway as well as sharpen tuning and gate auditory signals that are sent to downstream areas. This excitatory feedback loop from DCN to IC and back to DCN could underlie hyperexcitability in DCN, widely considered an etiology of tinnitus.
Study on the removal of the static Cr (VI) in water by graphene hydrogel (rGH)
Authors:   North China University of Science and Technology，Comprehensive test and Analysis Center，Tangshan Hebei 063210, Li Y. , Guo X. C. ,   North China University of Science and Technology，Yisheng College，Tangshan Hebei 063210, Chen Y. ,   North China University of Science and Technology，Comprehensive test and Analysis Center，Tangshan Hebei 063210, Cui Z. M. ,   North China University of Science and Technology，Comprehensive test and Analysis Center，Tangshan Hebei 063210, Lin S. L. ,   Shijiazhuang University，College of Chemical Technology，Shijiazhuang Hebei 050035
Published: March 2022

In this study, the reduced graphene hydrogel rGH with three-dimensional structure was prepared by chemical reduction method, that the adsorption and removal performance of heavy metal Cr (VI) in water was discussed. Graphene hydrogel is capable of high specific surface area, three-dimensional structure and narrow pore size distribution. Moreover, there are a large number of oxygen-containing functional groups such as hydroxyl groups on the surface of the material. Graphene hydrogel can remove Cr (VI) in water efficiently and continuously, and the removal of Cr (VI) in 1 ppm can keep over 99.5% in 6 hours, indicating the excellent application.
Morphological characteristics of β-irradiated lead oxide nano-sized particles
Authors: Aldaghri O. , Salih E. Y. ,   Department of Medical Physics, College of Medical Sciences Technologies, The University of Mashreq, 10021, Baghdad, Iraq, Ramizy A. ,   Department of Medical Physics, College of Medical Sciences Technologies, The University of Mashreq, 10021, Baghdad, Iraq, Sabri M. F. M. ,   Nano Micro Engineering Laboratory, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia, Madkhali N. ,   Department of Physics, College of Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13318, Saudi Arabia, Alinad T. ,   Department of Physics, College of Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13318, Saudi Arabia, Ibnaouf K. H. ,   Department of Physics, College of Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13318, Saudi Arabia, Eisa M. H. ,   Department of Physics, College of Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13318, Saudi Arabia
Published: March 2022

This work examined the beta irradiation and characterization of lead oxide nanoparticles samples that were prepared via pulsed laser deposition. The lead oxide nanoparticles samples were irradiated by beta-ray. Strontium 90 radioisotope was used as beta irradiation for different time periods (Days 1, 3, 4, and 5). The morphologies of lead oxide nanoparticles films were characterized with and without beta irradiation through the use of scanning electron microscope (SEM) and atomic force microscopy (AFM). According to the findings, beta radiation impacted lead oxide nanoparticles samples’ morphological properties. The details of experimental setups, sample preparation procedures, and data analysis, are explicated.
Effect of low energy proton and He particle irradiation on CsPbBr3 material
Authors:   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Mei H. Y. , Wu H. T. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Yao R. X. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Zhao L. Y. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Zheng X. Y. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Liu F. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Wen I. H. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China, Sun S. X. ,   Henan Provincial Key Laboratory of Smart Lighting,School of Information Engineering, Huanghuai University, Zhumadian 463000, China
Published: March 2022

In this paper, the effect of proton and He particle bombardment in CsPbBr3 material was investigated by the Monte Carlo simulation including ion range, backscattering, vacancies and sputtering yield. The energies of proton and He particle varied from 50 keV to 180 keV and the particle incidence angles increased from 0o to 89.9o . The calculated results showed that with the increase of incidence energies, the range and vacancies increased, and the backscattering ions and sputtering yield reduced for proton and He particle. Meanwhile, the vacancies, backscattering ions and sputtering yield induced by He particle were much more proton at the same energy. With the increase of incidence angles, the range and vacancies were reduced, and the sputtering yield increased for proton and He particle. Also, it is obvious that the effects of He particle on CsPbBr3 material were much more serious than proton.
Cytotoxicity of zinc oxide nanoparticles coupled with folic acid and polyethylene glycol
Authors:   Department of Physics, The University of Lahore, Lahore, Pakistan, Khalid A. D. , -ur-Rehman N. ,   Institute of Physics, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan, Hadi F. ,   Institute of molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan, Iqbal S. S. ,   Department of Physics, The University of Lahore, Lahore, Pakistan, Buzdar S. A. ,   Institute of Physics, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan, Khan A. K. ,   Institute of Physics, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
Published: March 2022

The anticancer mediators claim their activity in liquid form as a biocompatible and use in bios stems, which are mostly collected in fluid form. Control on the stability of metal oxide nanoparticles in parallel reducing the effect of large amount on their biological and cytotoxicity activities, remains a challenge. Here anticancer activity and cytotoxicity zinc oxide nanoparticles (NPs) have been presented that are coated with folic acid (F.A) and polyethylene glycol (PEG). The nanoparticles were synthesized by wet chemical method and characterized by x-ray diffraction; scanning electron microscopy and Fourier transform infrared spectroscopy. The cytotoxicity studies were performed on HepG2 cells.MMT assay was used to check the cell viability. The PEG and F.A capped ZnO NPs have shown reduction in cytotoxicity as compare to bare ZnO nanoparticles.
Is diabetic neuropathy associated with increased risk of developing mental disorders?
Authors: Rohde Christopher , Finnerup Nanna Brix , Schmitz Norbert , Jensen Troels Staehelin , Thomsen Reimar Wernich , Østergaard Søren Dinesen
Published: March 2022

Objective

It is largely unknown whether individuals with diabetic neuropathy face an increased risk of developing mental illness. Therefore, in a population-based cohort study, we aimed to examine whether individuals with diabetic neuropathy are at elevated risk of being diagnosed with a mental disorder compared to diabetes-duration-matched individuals without diabetic neuropathy.

Methods

We used the nationwide Danish registers to identify all individuals diagnosed with diabetic neuropathy between January 1, 1996, and January 1, 2019. For each of these individuals, we identified up to five individuals with diabetes, matched on the duration of illness, who were not diagnosed with diabetic neuropathy. We then compared incidence rates of mental disorders between individuals with diabetic neuropathy and the diabetes-duration-matched individuals using a Cox proportional-hazards model.

Restults

Individuals with diabetic neuropathy had a substantial and statistically significant increased risk of being diagnosed with any mental disorder (age- and sex-adjusted hazard rate ratio: 1.40, 95% CI: 1.31–1.48) as well as all specific mental disorders (psychotic disorder, bipolar disorder, unipolar depression, and/or anxiety disorder) compared with diabetes-duration-matched individuals without diabetic neuropathy.

Conclusions

Diabetic neuropathy appears to be associated with a substantially increased risk of developing a mental disorder. Knowledge of the potential mechanisms underlying this association could inform prevention and treatment and should therefore be pursued further.
Transcriptome in paraffin samples for the diagnosis and prognosis of adrenocortical carcinoma
Authors: Jouinot Anne , Lippert Juliane , Sibony Mathilde , Violon Florian , Jeanpierre Lindsay , De Murat Daniel , Armignacco Roberta , Septier Amandine , Perlemoine Karine , Letourneur Franck , Izac Brigitte , Ragazzon Bruno , Leroy Karen , Pasmant Eric , North Marie-Odile , Gaujoux Sébastien , Dousset Bertrand , Groussin Lionel , Libe Rossella , Terris Benoit , Fassnacht Martin , Ronchi Cristina L , Bertherat Jérôme , Assie Guillaume
Published: March 2022

Design

Molecular classification is important for the diagnosis and prognosis of adrenocortical tumors (ACT). Transcriptome profiles separate adrenocortical adenomas ‘C2’ from carcinomas, and identify two groups of carcinomas ‘C1A’ and ‘C1B’, of poor and better prognosis respectively. However, many ACT cannot be profiled because of improper or absent freezing procedures, a mandatory requirement so far. The main aim was to determine transcriptome profiles on formalin-fixed paraffin-embedded (FFPE) samples, using the new 3’-end RNA-sequencing technology. A secondary aim was to demonstrate the ability of this technique to explore large FFPE archives, by focusing on the rare oncocytic ACT variants.

Methods

We included 131 ACT: a training cohort from Cochin hospital and an independent validation cohort from Wuerzburg hospital. The 3’ transcriptome was generated from FFPE samples using QuantSeq (Lexogen, Vienna, Austria) and NextSeq500 (Illumina, San Diego, CA, USA).

Results

In the training cohort, unsupervised clustering identified three groups: ‘C1A’ aggressive carcinomas (n = 28, 29%), ‘C1B’ more indolent carcinomas (n = 28, 29%), and ‘C2’ adenomas (n = 39, 41%). The prognostic value of FFPE transcriptome was confirmed in the validation cohort (5-year OS: 26% in ‘C1A’ (n = 26) and 100% in ‘C1B’ (n = 10), P  = 0.003). FFPE transcriptome was an independent prognostic factor in a multivariable model including tumor stage and Ki-67 (OS HR: 7.5, P  = 0.01). Oncocytic ACT (n = 19) did not form any specific cluster. Oncocytic carcinomas (n = 6) and oncocytic ACT of uncertain malignant potential (n = 4) were all in ‘C1B’.

Conclusions

The 3’ RNA-sequencing represents a convenient solution for determining ACT molecular class from FFPE samples. This technique should facilitate routine use and large retrospective studies.
Mineralocorticoid receptor antagonists, heart failure and predictive biomarkers
Authors: Karthigan Nikshay , Lockwood Siobhan , White Anthony , Yang Jun , Young Morag J
Published: March 2022

The mineralocorticoid receptor is a steroid hormone receptor that is well known for its involvement in fluid and electrolyte homeostasis in epithelial cells present in the distal nephron. The inappropriate activation of this receptor is now known to be implicated in various pathophysiological mechanisms in heart failure. Mineralocorticoid receptor antagonists offer substantial clinical benefit in patients with heart failure with reduced ejection fraction; however, for patients with heart failure with preserved ejection fraction, the treatment benefit is less clear. Biomarkers that can predict response to mineralocorticoid receptor antagonist treatment do not currently exist. Potential biomarkers may be modulated either directly by the mineralocorticoid receptor or indirectly via downstream effects and be able to reflect treatment outcomes, particularly changes in key parameters of cardiac health and function. A biomarker or set of biomarkers that can reliably predict responsiveness to mineralocorticoid receptor antagonist treatment at an early stage may allow for the selection of patients who are most likely to benefit from treatment thereby avoiding any unnecessary side effects associated with the use of these medications.
Social Exclusion and Tendency to Violence as Predictors of Alienation from School among High School Students in Turkey
Authors: Kabakli Cimen Latife
Published: March 2022

This study was carried out to explain social exclusion and tendency to violence as predictors of alienation from school among adolescents. The sample of the study consisted of 595 students studying in different high schools. The data were analyzed using descriptive statistics. According to the results obtained, it was determined that the participants' levels of the tendency to violence, social exclusion, and alienation from school were not very high, and the participants were mostly socially distanced. It was determined that students' levels of the tendency to violence had positive and significant effects on “powerlessness,” “normlessness,” “meaninglessness,” and “social isolation” that are the sub-dimensions of alienation from school. Furthermore, it was determined that "Ignorance," one of the sub-dimensions of social exclusion, had positive and significant effects on all sub-dimensions other than the "social isolation" sub-dimension, one of the sub-dimensions of alienation from school, and that ignorance had a negative and significant effect on social isolation. It was determined that "exclusion," one of the sub-dimensions of social exclusion, had positive and significant effects on “powerlessness” and “social isolation,” which are among the sub-dimensions of alienation from school, however, it had no significant effects on the sub-dimensions of “normlessness” and “meaninglessness.”
Memory Culture in Scandinavian Studies: Abstract Book and Program of the 33d Study Conference of the International Association for Scandinavian Studies (IASS), Vilnius, August 3-6, 2021
Authors: Steponavičiūtė Aleksiejūnienė Ieva , Vaicekauskienė Loreta , Zukienė Rūta
Published: March 2022

The history of IASS goes back to Cambridge 1956 and counts 32 study conferences. The latest five of these were hosted by the Universities of Lund (Sweden, 2010), Riga and Daugavpils (Latvia, 2012), the University of Agder in Kristiansand (Norway, 2014), the Universities of Groningen (The Netherlands, 2016) and Copenhagen (Denmark, 2018). The Centre of Scandinavian Studies at Vilnius University was proud of being entrusted with hosting the 33rd conference of IASS and we were thrilled to anticipate everyone coming to Vilnius in summer 2020. However, it became the first time when the conference would basically be held on the World Wide Web − as the world was hit by a global disaster – the Covid19 pandemic. For the same reason, and again for the first time in the history of IASS, the conference was put on hold and from now on it will probably always be held in odd years, the next conference being already scheduled for 2023. However, despite the fact that the conference of 2021, due to these reasons, was somewhat unusual in its format it was lacking neither in academic quality, nor in the joy of interaction with old and new colleagues that IASS conferences have always been famous and popular for.
Incidental breast lesion on chest CT scan: a review
Authors: Vo Quoc Duy , Molteni Thierry , Patrique Patrique Oliveira Santos , Niasme Elodie , Haefliger Laura
Published: March 2022

Most breast cancers are diagnosed by conventional breast imaging which includes mammography, ultrasound and MRI. However, CT is an often overlooked modality in the detection and diagnosis of breast cancer. Incidental findings of breast cancer by CT are not so rare. This article aims to aware radiologists and gynaecologists to the potential of breast cancer detection with CT. In this brief review of the literature, we will discuss the morphological characteristics of breast tumours on CT and the imaging mangement of suspicious lesions discovered on CT.
Gastrostomy Tube Placement and Resource Use in Neonatal Hospitalizations With Down Syndrome
Authors: Doshi Harshit , Shukla Samarth , Patel Shalinkumar , Bhatt Parth , Bhatt Neel , Anim-Koranteng Comfort , Ameley Akosua , Biney Bernice , Dapaah-Siakwan Fredrick , Donda Keyur
Published: March 2022

OBJECTIVES

To determine the trends in gastrostomy tube (GT) placement and resource utilization in neonates ≥35 weeks’ gestational age with Down syndrome (DS) in the United States from 2006 to 2017.

METHODS

This was a serial cross-sectional analysis of neonatal hospitalizations of ≥35 weeks’ gestational age with International Classification of Diseases diagnostic codes for DS within the National Inpatient Sample. International Classification of Diseases procedure codes were used to identify those who had GT. The outcomes of interest were the trends in GT and resource utilization and the predictors of GT placement. Cochran-Armitage and Jonckheere-Terpstra trend tests were used for trend analysis of categorical and continuous variables, respectively. Predictors of GT placement were identified using multivariable logistic regression. P value <.05 was considered significant.

RESULTS

Overall, 1913 out of 51 473 (3.7%) hospitalizations with DS received GT placement. GT placement increased from 1.7% in 2006 to 5.6% in 2017 (P <.001), whereas the prevalence of DS increased from 10.3 to 12.9 per 10 000 live births (P <.001). Median length of stay significantly increased from 35 to 46 days, whereas median hospital costs increased from $74 214 to $111 360. Multiple comorbidities such as prematurity, sepsis, and severe congenital heart disease were associated with increased odds of GT placement.

CONCLUSIONS

There was a significant increase in GT in neonatal hospitalizations with DS, accompanied by a significant increase in resource utilization. Multiple comorbidities were associated with GT placement and the early identification of those who need GT could potentially decrease length of stay and resource use.
Transferencia de la polaridad semántica de frases idiomáticas a comentarios de opinión
Authors: Casasola Murillo Edgar , Leoni de León Jorge Antonio
Published: March 2022

Las reacciones en redes sociales a propósito de un comentario pueden ser clasificadas en positivas, negativas o neutras, según la opinión del usuario o emisor sobre el tema en juego. Las frases idiomáticas son portadoras de un valor emocional, que va de positivo a negativo (lo que conocemos como polaridad). En nuestra investigación, establecimos que la aparición de una frase idiomática negativa en una opinión en redes sociales está directamente vinculada con la polaridad de la totalidad del comentario. Es decir, que la polaridad de la expresión es transferida al comentario propiamente dicho.
Índice de riqueza léxica en redacciones escritas por estudiantes universitarios
Authors: Madrigal Marta , Vargas Ericka
Published: March 2022

En este trabajo se analizará la riqueza léxica en los escritos académicos realizados por estudiantes universitarios. La motivación de dicho análisis surge a partir de las deficiencias léxicas detectadas en las composiciones de los alumnos en el Curso Básico de Redacción de la Universidad de Costa Rica. El objetivo principal es establecer la media de riqueza léxica y compararla con la cantidad alcanzada por escritores profesionales. Además, se identificarán las palabras de contenido que más se repiten en el corpus y las posibles causas de la falta de variedad léxica dentro del texto. Finalmente, se brindarán algunas recomendaciones para que los estudiantes mejoren su desempeño escrito en términos de léxico.
Los diccionarios de las lenguas indígenas de Costa Rica: Del formato bilingüe alfabético al temático pictográfico
Authors: Sánchez Avendaño Carlos
Published: March 2022

En este trabajo se comentan las principales características de las obras lexicográficas publicadas sobre las lenguas indígenas de Costa Rica y se problematiza en torno a la accesibilidad del formato bilingüe alfabético tradicional para los miembros de las comunidades de hablantes. Posteriormente, se discute sobre la especificidad de la lexicografía de lenguas en peligro y se sistematiza la experiencia de elaboración de diccionarios temáticos pictográficos.
Acción social, docencia e investigación en la Universidad de Costa Rica y su articulación
Authors: Azofeifa Ramos Silvia Elena
Published: March 2022

Introducción

En el 2018 se cumplió 100 años de la Reforma de Córdoba, evento que sentaría las bases para el modelo universitario latinoamericano que moldea a la Universidad de Costa Rica desde su fundación.

Objetivo

En el marco de las X Jornadas de Investigación del Instituto de Investigaciones Sociales, se hace una revisión de las propuestas y compromisos de la Reforma de Córdoba para analizar la acción social (extensión universitaria) como pilar de la Universidad de Costa Rica, junto con la investigación y la docencia.

Método

Para ello se hace una revisión histórica del contexto en el que surge la Reforma de Córdoba en 1918. Se repasa la manera en la que la Universidad de Costa Rica ha concebido la acción social y algunos de los debates que la atraviesan actualmente.

Resultados

A partir de 1918 se constituyó un modelo universitario original y contextualmente adaptado a las demandas sociales de la época, muchas de las cuales siguen vigentes. Se identifican vínculos   para que esta actividad funcione de manera articulada con la investigación y la docencia.

Conclusiones

Se concluye que no es ético repetir discursos “decoloniales”, si reproducimos este tipo de prácticas desde nuestro quehacer académico, al conservar toda la producción intelectual y los conocimientos técnicos que aquí se adquieren, únicamente para quienes nos encontramos dentro de los muros universitarios.
Condiciones Laborales del personal docente interino de la Sede de Occidente
Authors: Jiménez Bercy Silva
Published: March 2022

Introducción

El presente artículo pretende socializar los hallazgos preliminares de la investigación denominada: Condiciones laborales del personal docente interino de la Sede de Occidente, durante el periodo 2017-2019.

Objetivo

El objetivo es poder identificar las condiciones laborales de este sector, así como las estrategias individuales, colectivas e institucionales para su atención.

Método

Incluye el análisis de aspectos tanto cuantitativos como cualitativos, entre los que se encuentran: número de docentes por departamentos, modalidad de contratación y percepción que tienen sobre sus condiciones de trabajo. 

Resultados

Entre los resultados obtenidos se identifica que al año 2018 el 83 % de los docentes se encuentran en condición de interinazgo, además que existe una tendencia al deterioro de las condiciones laborales, donde se presentan diferentes modalidades de contratación que buscan el abaratamiento de la fuerza de trabajo, como son los contratos sin continuidad donde el docente queda sin salario hasta por tres meses en los periodos llamados inter-ciclo. Otro de los resultados es la falta de estrategias colectivas e institucionales para la atención de las condiciones laborales, al igual que la percepción que poseen las personas entrevistadas de recurrir a la meritocracia y mendicidad de los derechos laborales.

 

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