bluuebunny/crossref_metadata_2025 huggingface dataset:
Drivers of cost and time overruns: A client and contractor perspective
Authors: Dahlin Peter , Pesämaa Ossi
Published: May 2021

Large infrastructure investments are expected to be of sustained value to society for a long time. Such investment projects include, for instance, hospitals, tunnels, sport arenas, power plants, roads, railways, and bridges. They involve a complex organization of contracts and agreements. The client is expected to plan, procure, and determine the critical steps of a project, while the contractor should solve issues raised by the client. Many of these agreements are path-dependent and reflect past routines, experiences, and contacts. As such, many investments tend to return to similar sources instead of replacing routines and collaborations that did not work. This can cause change orders that furthermore reflect consequences such as cost and time overruns. While much is known about these effects in construction projects, this paper sheds light on the drivers of change orders. We build upon a sample of 234 observations responding to a survey on investment planning. The results show that project assumptions are often wrong and inadequate in large investments. Such wrong assumptions are caused by interpersonal and leadership issues, poor planning, or sometimes even intentional profit-seeking. Our results show that clients and contractors have different perceptions and enter contractual obligations differently. The implication is, therefore, that better routines of documentation, more frequent feedback, and more accurate or precise standards may close the gap between planning and what is actually achieved. More precise contractual agreements may also create a better process to procure, manage projects, and allocate resources.
Spoofing and Jamming of GNSS Signals: Are They Real and What Can We Do About Them
Authors: Meggs RW , Watson RJ
Published: May 2021

Put simply, ‘spoofing’ is a means of controlling the reported position and time of a GNSS receiver. Spoofing has now been well demonstrated in the experimental context, but until a few years ago it was regarded as “…a bit like UFOs: much speculation, occasional alarms at suspected instances, but little real-world evidence of its existence” (Ref. 1). In the intervening years spoofing has transformed from a research laboratory into an emerging threat. In this paper we focus on radio-frequency attack as the primary method of spoofing. However there is also the possibility of cyber-attack on GNSS systems, in which there is interception and modification of computed position between the receiver and application. It had perhaps previously been considered that the technology and know-how “barrier to entry” to produce an effective spoofer was itself a significant deterrent. However, the commercial availability of inexpensive (sub £250) software defined radio systems, low-cost computing and open-source GNSS signal generator software has all but eliminated this barrier. This paper will consider various methods of spoofing, means of detecting spoofing through analysis of signal anomalies and also mitigation of spoofing at the physical layer via the antenna and signal processing and at the software application layer through the detection of anomalies.
Retrofit an 11-meter yacht for autonomous navigation
Authors: You X , Ma F , Wang X
Published: May 2021

Intelligent/autonomous ships form a rising field that brings beneficial changes to waterborne transportation such as relieving labour shortages, avoiding collisions, and providing assistance to humans. Many autonomous navigation attempts have been carried out on ship models rather than real ships. The results of these studies have certain gaps with the results of full-scale ships. Cost and risk of intelligent ships for autonomous navigation are yet unclear, which makes retrofitting existing ships for tests and development appealing. This paper introduces the process of retrofitting a full-scale 11-meter yacht, including mechanical retrofit, hardware redesign, software deployment, and functional testing. The process is proposed as a solution of ship retrofit for autonomous navigation functions like heading control, path following, and collision avoidance. In the end, this paper concludes a plan of hardware and software that could help find more retrofit solutions, providing a reference for academic research and practical applications.
Integrating autonomous system of systems in the Royal Netherlands Navy.
Authors: Peters F , den Breejen E
Published: May 2021

Future naval operations will increasingly incorporate Maritime Unmanned Systems (MUS). Embedding autonomous MUS in a military organization has its challenges. To overcome these challenges the Royal Netherlands Navy has started the development of a general system of systems architecture, GENIUS. A general outline and functions are described in this paper as well as the current state and its future configurations in the Royal Netherlands Navy.
A importância da educação na construção da cidadania: uma análise do Programa Bolsa Família
Authors: Teodoro Luiz Claudio Almeida , Oliveira Carlos Eduardo
Published: May 2021

Enquanto um pré-requisito para outros direitos, a educação é considerada como um direito genuíno da Cidadania. No entanto, a história da educação no Brasil é marcada pelo elitismo e exclusão. O Estado Brasileiro só irá reconhecer a educação como direito de todos na constituição de 1934. Porém, somente após a constituição de 1988 o país alcançou avanços significativos na área. As políticas de assistência educacional e social são fundamentais para esse avanço, sobretudo na garantia da inclusão dos mais pobres. O objetivo deste trabalho é analisar como o Programa Bolsa Família, através da condicionalidade em educação, pode ser um elemento importante na quebra intergeracional da exclusão educacional e da pobreza, a condicionalidade cumpre um papel estratégico para o desenvolvimento da cidadania no país.
Agricultura orgânica e agroecologia como ferramenta de educação
Authors: De Assis Lucas Lenin Resende , Silveira Luís Cláudio , Moreira da Silva Iberê Martí
Published: May 2021

Esse artigo descreve a experiência em uma escola no município de Lavras, Minas Gerais, ao apresentar conceitos básicos, bem como a existência dos alimentos orgânicos, abordando a Agroecologia e a suas vantagens sob os demais métodos de agricultura. Antes e após o ciclo de atividades aplicamos questionários simples para nos orientar quanto à direção a ser tomada e os resultados foram alcançados pela análise de conteúdo. Foi observado o desconhecimento por parte das crianças quanto ao que é a universidade e seu papel como parte da sociedade, algo que para eles pareceu ser uma realidade bem distante por vários fatores, dentre questões de cunho social e econômicas. Com o desenvolvimento deste projeto foi possível também despertar nas crianças o senso crítico e a importância do consumo de alimentos de qualidade, junto aos princípios agroecológicos.
A Inspetoria de Educação Física de Minas Gerais: elementos de complexificação da formação de professoras para o ensino da disciplina (1927-1937)
Authors: Silva Giovanna Camila da
Published: May 2021

Este estudo investigou as ações de qualificação do professorado realizadas pela Inspetoria de Educação Física de Minas Gerais, no período de 1927 a 1937. As fontes foram constituídas pela legislação estadual, por periódicos de ação governamental e impressos sobre Educação Física. O texto apresenta as motivações para a criação de um órgão específico para organizar ações relativas à presença da Educação Física nas escolas, analisa o projeto empreendido pelos sujeitos que compuseram a Inspetoria com destaque para o investimento central no aperfeiçoamento docente, por meio de cursos intensivos e de circulação de impressos, e ainda discorre sobre o declínio de tal órgão. Nas ações de formação de professoras é possível afirmar que a Inspetoria ultrapassou os limites de subsídios eminentemente práticos e alargou os conhecimentos das professoras responsáveis por ministrar Educação Física nas escolas.
Pedagogias da noite: experiências e sensações coletivas em um parque público
Authors: Silva Eloenes Lima
Published: May 2021

Como recorte de pesquisa realizada junto ao campo dos Estudos Culturais e Educação, o artigo tem por objetivo dar visibilidade a modos pedagógicos de viver na noite mediante a identificação de experiências coletivas durante um evento noturno no maior parque público da cidade de Porto Alegre, Brasil. Na primeira parte são propostas articulações teóricas entre “pedagogia”, “experiência” e “lugar”. Em seguida são destacados caminhos metodológicos utilizados durante a pesquisa. Na terceira parte, analisamos a música executada ao vivo, as produções artesanais, os “abraços grátis” e outras intervenções por meio da apresentação de “cenas noturnas” compostas a partir das abordagens, relatos e registro de práticas realizadas pelos participantes do evento.  Os resultados apontam que encontros, convívios, aproximações e trocas sociais são experiências vividas através de sensações em comum em que os afetos, a segurança, o “estar junto” funcionam como pedagogias, orientando e conduzindo os sujeitos em lugares noturnos da cidade.
Contradições entre projetos e práticas anti-homofóbicas no contexto educacional da escola
Authors: Rangel Mary , Caetano Marcio , De Sousa Nilcelio Sacramento
Published: May 2021

O enfoque temático deste estudo são as contradições entre os projetos anti-homofóbicos na escola e as suas práticas. Para tanto, assumiu-se a proposta de exemplificar essas contradições ao analisar dez artigos entre os que fazem parte do acervo obtido em uma pesquisa sobre o estado da arte sobre a diversidade sexual e educação, implementada com apoio do CNPq. Na metodologia, adotou-se o procedimento de revisão narrativa, fazendo-se uma síntese descritiva, seguida de comentário apreciativo do conteúdo, com atenção a elementos contraditórios entre projetos e práticas. Na discussão conclusiva, ressaltamos que, embora se encontrem discrepâncias entre o que se propõe e o que se pratica, avanços significativos dos anos 1990 até a metade desta década não podem ser ignorados. Valoriza-se, portanto, o incremento de pesquisas que repercutam na desconstrução de preconceitos que constituem a substância da homofobia.
Autoimagem e a relação com a vida sexual das mulheres
Authors: Malta Nathalia Jung Ferreira , Cestari Maria Elisa Wotzasek , Pisicchio Rosely Jung , Pinto Keli Regiane Tomeleri da Fonseca , Medeiros Fabiana Fontana
Published: May 2021

Objetivo: Identificar a relação da autoimagem feminina com a atividade sexual e o prazer sexual. Métodos: Trata-se de um estudo descritivo com abordagem qualitativa. Os dados foram analisados pela técnica de Análise de Conteúdo proposto por Bardin. Resultados: A Imagem Corporal foi entendida como a construção corporal percebida pela mulher. Algumas mulheres idealizaram o corpo como um corpo jovem e com padrão midiático. Sentimento de sofrimento com relação à percepção de outras pessoas diante de um corpo fora dos padrões culturais estabelecidos pela sociedade e a dificuldade para encontrar roupas fabricadas para mulheres acima do peso considerado adequado e modelagens apropriadas. Quanto à relação da autoimagem com a atividade sexual e o prazer sexual, as participantes referiram vergonha de seu corpo, interferindo na sua relação sexual. Conclusão: O presente estudo evidenciou que o corpo não revela apenas componentes estruturais, mas também fatores sociais, psicológicos, culturais e sexuais que adquirem singularidade. Por fim, os padrões corporais e a sua relação com a vida sexual são modulados em cada época e sempre estarão em movimento, sendo um desafio para a promoção da saúde da mulher.
Delineamento epidemiológico dos casos notificados de 2008 a 2018 de HIV em pessoas idosas no estado de Pernambuco - Brasil
Authors: Vicente Julianne Damiana da Silva , Dantas Camila de Farias , Silva Liniker Scolfild Rodrigues da , Lima Kelly Regina Machado de , Santana Juliane Raquel Miranda de , Trajano Leonia Moreira , Vicente Julianna Carolina da Silva , Cunha Márcia Andrea Oliveira da
Published: May 2021

Objetivo: Este estudo tem por objetivo delinear o perfil epidemiológico dos casos notificados de HIV em pessoas idosas no período de 2008 a 2018, no estado de Pernambuco, Brasil. Métodos: Trata-se de um estudo epidemiológico descritivo, com abordagem quantitativa, tendo como população e amostra a população idosa do estado de Pernambuco notificada para infecção do vírus HIV entre os anos de 2008 a 2018. Os dados foram coletados através do Sistema de Informação de Agravos de Notificação (Sinan) de Pernambuco, a tabulação dos dados foi realizada por meio do tabulador Tabwin. O estudo foi aprovado por Comitê de Ética em Pesquisa. Resultados: Pode-se observar que o maior percentual de casos de HIV em pessoas idosas no estado de Pernambuco no período de 2008 a 2018, está concentrado na I Região de Saúde, com 69,2% e no sexo masculino com 63,8%. Cerca de 88% das pessoas notificadas residem em área urbana. Verificou-se que houve um crescimento significativo dos casos de HIV na pessoa idosa entre os anos estudados. Conclusão: É fundamental que sejam elaboradas novas medidas de prevenção a esta IST, possibilitando ao idoso tornar-se protagonista do autocuidado e incorporando este assunto à rotina dos serviços de saúde.
Premontrei prépostságok a középkori Magyarországon, különös tekintettel a Kaposfői Szent Benedek prépostságra
Authors: Aradi Csilla
Published: May 2021

The paper deals with the diffusion of Premonstrat-ensian monasteries in Hungary, their relations and the role they played in pastoral life. it also gives a brief insight into the only Norbertine foundation in Somogy county (Kaposfő).
Bőrcserző és bőrlábbeliket készítő kézművesek a csurgói „Magyar Céhben” (1810–1872)
Authors: Knézy Judit
Published: May 2021

In the studies and works concerning the clothing of the common people living in Somogy county their footwear are rarely mentioned. the examination of the local Guilds’ pa-perwork can fill these gaps in our knowledge. One can find there detailed description of cuts and masterpieces, treaties and bills of the guilds’ workers, and cash books. this study examines the written data of the so called ’Hungarian’ Guild in the markettown of Csurgó in the time between 1810 and 1872, as this was the exact time when the usage of footwear began to follow quicklier the pattern of larger towns’ clothing habits.
Az államfő árnyékában. Az Elnöki Tanács Elnökének felesége, Losonczi Pálné kitüntetései
Authors: Varga Éva , Gyurákovics Norbert
Published: May 2021

A short essay was published about Pál Losonczi, the Presidential Council’s president and about his medals, which are owned by our museum int he pages of Numizmatikai Közlöny. Now our main purpose is to elaborate the medal-col-lection of the wife of the former President. As a part of diplo-matic protocol, Mrs. Pálné Losonczi often kept his husband’s company during his external visits, when she also got pres-tigous medals. In our opinion all of information about prize-winners belong to the verification of the objects. Our script tries to answer the question, who Mrs. Pálné Losonczi was with the technique of oral history. After it her four medals will be intro-duced professionally, which are held in our museum right now.
Botanikai állapotfelmérés Somogydöröcske térségében (Külső-Somogy, Hungary)
Authors: Juhász Magdolna
Published: May 2021

The vegetation was investigated on loess hills and the adjoining floodplain rivulet Koppány in SW Hungary. The aim of the botanical survey was the registration of present bo-tanical condition, as first step of landscape restoration plan-ning. It was found, that many species of natural phytocoeno-sis are encountered, but overall in disturbed vegetation, not by typical coenological conditions. The remainder species of hilly forests refer early presence of xerotherm oak woods (Vicio sparsiflorae-Quercetum pubescentis), illyrian beech woods (Vicio oroboidi-Fagetum) and illyrian oak-hornbeam (Helleboro dumetorum-Carpinetum) forests. The hilly grass-lands are low-natural fallows. The natural vegetation of al-luvium rivulet Koppány consist of mesotrophic wet meadows, tall-sedge beds and tall-herb vegetation of floodplains.
In Situ Probing Potassium-ion Intercalation-induced Amorphization in Crystalline Iron Phosphate Cathode Materials
Authors: ozdogru bertan , Cha Younghwan , Murugesan Vijay , Song Min-Kyu , capraz ozgur
Published: May 2021

Na-ion and K-ion batteries are promising alternatives for large-scale energy storage applications due to their abundancy and lower cost. However, designing an electrode structure to reversibly accommodate these large alkali-ions is the remaining challenge before their commercialization. Intercalation of these large ions could cause irreversible structural deformations and amorphization in the crystalline electrodes. The designing of new amorphous electrodes is another route to develop electrodes to store these ions reversibly. Lack of understanding of dynamic changes in the amorphous nanostructures during battery operation is the bottleneck for further developments. Here, we report the utilization of in situ digital image correlation and in-operando X-ray diffraction (XRD) techniques to probe dynamic changes in the amorphous phase of iron phosphate during potassium intercalation. In-operando XRD demonstrates amorphization in the electrode’s nanostructure during the first charge / discharge cycle. In situ strain analysis detects the reversible deformations associated with redox reactions in the amorphous phases. This method offers new insights to study mechanics of ion intercalation in the amorphous nanostructures.
A Framework for Quantifying Uncertainty in DFT Energy Corrections
Authors: Wang Amanda , Kingsbury Ryan , McDermott Matthew , Horton Matthew , Jain Anubhav , Ong Shyue Ping , Dwaraknath Shyam , Persson Kristin
Published: May 2021

In this work, we demonstrate a method to quantify uncertainty in corrections to density functional theory (DFT) energies based on empirical results. Such corrections are commonly used to improve the accuracy of computational enthalpies of formation, phase stability predictions, and other energy-derived properties, for example. We incorporate this method into a new DFT energy correction scheme comprising a mixture of oxidation-state and composition-dependent corrections and show that many chemical systems contain unstable polymorphs that may actually be predicted stable when uncertainty is taken into account. We then illustrate how these uncertainties can be used to estimate the probability that a compound is stable on a compositional phase diagram, thus enabling better-informed assessments of compound stability.
Hodgkin lymphoma. ASCO, EHA and ASH 2020 news
Authors: Demina Elena A.
Published: May 2021

The review shows the most interesting and promising studies presented at major international conferences of the American Society of Clinical Oncology, the European Hematology Association, and the American Society of Hematology in 2020. The main aim of the therapy for Hodgkin lymphoma (HL), which have been formulated over the past 20 years, is the highly effective therapy and high quality of life, and the main possibility to solve this task is positron emission tomography (PET). The studies presented at conferences this year have shown that PET-adapted therapy has become the basis of modern HL therapy. The second equally interesting direction presented at the conferences this year is the widespread use of targeted (brentuximab vedotin) therapy and immunotherapy (nivolumab, pembrolizumab) in combination with standard chemotherapy not only in patients with relapsed/refractory HL, but also as first-line therapy, including the patients of an elderly section. The combination of brentuximab vedotin and immunotherapy during all lines of HL treatment, as well as brentuximab vedotin and immunotherapy consolidation after high-dose chemotherapy and autologous stem cell transplantation are another direction to improve the efficacy of therapy in patients with HL.
New developments in the treatment of follicular lymphoma/ marginal zone lymphoma (according to the Congress of the American Society of Hematology – 2020)
Authors: Babicheva Lali G.
Published: May 2021

Relevance. Follicular lymphoma (FL) and marginal zone lymphoma (MZL) are the most common variants of indolent non-Hodgkin lymphoma (iNHL). Despite the adequate choice of the first-line therapy, 10 15% of affected patients with iNHL develop refractory disease, and in most of the cases the relapse of the disease among the others patients is detected, and each subsequent remission is shorter than the previous. According to the data of the National LymphoCare Study Group, the relapses that can occur during the first 2 years (POD24) after the beginning of the first-line therapy with R-CHOP in patients with FL, as well as with MZL, have a negative impact on the prognosis: 5-year overall survival in these patients decreases from 90 to 50%. The arsenal of therapy options is actively expanding along with a deep understanding of the biological basis of the disease development. At present, the most topical problem remains the choice of the best approach for each patient the personalization of the therapy. The review includes the data from clinical trials concerning FL and MZL treatment presented at the Congress of the American Society of Hematology in 2020. There are a large number of studies concerning new anticancer drugs in the world, such as monoclonal antibodies to different targets on the surface of B-cells, macrophages, bispecific antibodies, antibody conjugates, immunomodulators, BCR signaling pathway inhibitors (Bruton tyrosine kinase, PI3K inhibitors), immune checkpoint inhibitors and many others.
Conclusion. The development of weighting approach for the choice of therapy will give a chance to patients with FL and MZL to stay alive up to the next era of new effective anticancer drugs. Future strategies, according to the current studies, show the trend away from the cytotoxic chemotherapy in iNHL therapy.
Augury
Authors: Blake Christopher
Published: May 2021

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Aftermath and midst of a nightmare: A pediatrician’s COVID-19 lament
Authors: Rule Amy RL
Published: May 2021

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COVID-19 pandemic: one person, various perspectives
Authors: Beaulieu Marie-Claude
Published: May 2021

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Essential self-care for doctors during the pandemic
Authors: Moore Sarah
Published: May 2021

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Use soap & Mango spoiled
Authors: Niburski Kacper
Published: May 2021

N/A
Inside the ‘black box’ of a long-term sport-based youth development boxing academy in New Zealand
Authors: Gordon Barrie , Wright Paul M , Hemphill Michael A , Sauni Pale
Published: May 2021

No description supplied
MANIFESTATION OF OROFACIAL PATHOLOGY IN CHILDREN WITH CHRONIC KIDNEY DISEASE
Authors: N.S. Morozova , A.A. Elovskaya
Published: May 2021

Urological diseases are one of the reasons that lead to reduced quality of life, disability and premature mortality and create a number of socially significant issues. In the last two decades it was observed that intensive development in methods of diagnostics and treatment of renal diseases in pediatric nephrology has led to decrease of mortality level among patients. Therefore, the number of children with these pathologies has risen in dental practice. Children suffering from chronic kidney disease require particular attention from dentists. This is due to renal disturbance has a negative effect on dentoalveolar system. It can be manifested as structural jawbone changes, temporomandibular joint function disturbance, periodontal and oral mucosal diseases, salivary composition, quality, quantity and consistency characteristics changes, dental hard tissues defects, pulp calcification due to urological diseases. In this regard, it is highly important to exclude pathological focus in oral cavity in this group of patients. Based on this, such patients need specialized dental care. However, the lack of a systematic approach and understanding of the mechanisms of the dentoalveolar anomalies occurrence of patients with chronic kidney disease limits dentists in correct differential diagnosis and prevention of dental disease complications against the background of underlying disease. That is why the aim of this article - to inform dentists about full spectrum of dentoalveolar system changes in children and adolescents with chronic kidney disease.
PROSPECTS FOR USING ASTRAGALUS ONOBRYCHIS AS A SOURCE OF NATURAL ANTIOXIDANTS
Authors: Т.А. Pozdnyakovа , Е.S. Kuleshovа , R.A. Bubenchikov
Published: May 2021

The predominance of synthetic and genetically modified foods in the diet of a modern person often leads to disruption of natural metabolic processes and the accumulation of toxic free radicals in the body, which provokes the development of various diseases. Natural antioxidants from medicinal plants can help maintain health and stop the processes of peroxidation. In our opinion, Аstragalus onobrychis can become a promising source of natural antioxidants. The aim of this study was to establish the antioxidant activity in extracts from the herb Astragalus onobrychis. In order to obtain objective and reliable results during our research, we used two methods: the method of titrimetry and spectrophotometry of free radicals. The titrimetric method is based on the chemical interaction between an oxidizing agent (potassium permanganate) and natural antioxidants present in extracts from plant raw materials, since they exhibit the properties of reducing agents. The spectrophotometric method makes it possible to assess the value of antioxidant activity and the duration of the reaction by assessing the interaction of 2,2-diphenyl-1-picrylhydrazil with plant antioxidants. To establish the relationship between the antioxidant activity and the presence of phenolic compounds in the plant, the content of flavonoids and hydroxycinnamic acids in the herb Astragalus onobrychis was determined. As a result of the studies, the total antioxidant activity of extracts from the herb Astragalus onobrychis was established and it was revealed that its value depends on the type of extractant used, since this factor is associated with the content of various groups of natural antioxidants in the extraction. The data obtained indicate the prospects of using the herb Astragalus onobrychis as a source of natural antioxidants.
EPIDEMIOLOGICAL CHARACTERISTICS OF BREAST CANCER IN THE REPUBLIC OF MORDOVIA
Authors: O.N. Deryabina , E.V. Blinova , E.A. Dagar , O.M. Tumutolova
Published: May 2021

The article analyzes the main epidemiological characteristics of breast cancer in the Republic of Mordovia in comparison with the Russian Federation. Based on the official accounting and reporting documentation for 2011-2019. the territorial and age-specific features of the incidence were determined, the structure of pathomorphological forms of breast cancer was assessed, the weighted average cost of providing specialized medical care for breast neoplasms in a hospital in the Republic of Mordovia was calculated. It has been shown that the incidence of breast cancer in the Republic of Mordovia for 2011-2019 increased, which corresponds to the all-Russian laws: 6.11 per 100 thousand women in the age group of women 25-29 years old to 213.14 in the age group 60-64 years. Infiltrating ductal carcinoma prevailed in the structure of the pathomorphological form of breast cancer among the inhabitants of the Republic - 58.8%. It has been shown that the cost of providing specialized hospital care for stage III breast cancer is 8 times higher than for stages I-II of breast cancer. Thus, the analysis showed that breast cancer is a serious medical and social problem, and effective treatment of the disease requires costly treatment in a specialized hospital, and the cost of drug therapy for the disease increases significantly at advanced stages.
CORONARY ARTERIES DAMAGE FEATURES IN IN YOUNG AND MIDDLE-AGED MEN WITH MYOCARDIAL INFARCTION AND RECURRENT EPISODES OF ISCHEMIA
Authors: S.Yu. Epifanov , A.V. Sotnikov , D.V. Nosovich
Published: May 2021

Relevance. Recurrent ischemic events (RIS) adversely affect the duration of treatment and the prognosis of myocardial infarction (MI).
Aim. To evaluate the coronary arteries condition in men under 60 years old (y.o.) with RIS and MI to improve understanding of the mechanisms of development and prevention.
Material and methods. The study included men 19-60 years old with type I of MI. Patients were divided into two age-comparable groups: I - study group, with RIS (early postinfarction angina pectoris and / or recurrent MI) - 26 patients; II - control, without them - 114 patients. A comparative assessment of angiographic data in the selected groups was performed.
Results. Patients in the study group had a greater (15.5%) than in the control (7.9%; p = 0.01) history of coronary artery bypass surgery, the degree of infarction-related artery stenosis (96.9 ± 7.7 and 92.3 ± 10.8%, respectively; p = 0.02). The magnitude of the narrowing of the coronary artery was associated with the coefficient of atherogenicity (r = 0.87; p <0.05), end-systolic (r = 0.53; p <0.05) and diastolic (r = 0.6; p <0, 05) left ventricle (LV) sizes, glomerular filtration rate (r = -0.5; p <0.05) in the first hours of MI, creatinine in the first hours (r = 0.47; p <0, 05) and at the end of the third MI week (r = 0.65; p <0.05).
Conclusions. In men under 60 y.о. with RIS during MI, the most pronounced association with a history of coronary artery bypass surgery and a greater lumen narrowing of the infarct-associated artery, which, in turn, increased with impaired renal function and lipid metabolism, and was also associated with LV dilatation.
DIGITAL MARKETING IN PHARMACY: PROSPECTS AND RESULTS
Authors: N.B. Dremova , T.G. Afanasyeva , N.I. Afanasyeva , V.V. Chebotok
Published: May 2021

Digital marketing is now becoming an integral part of marketing strategies for most companies in all sectors of the modern economy, including manufacturing and retail pharmaceutical organizations. The issues of promoting pharmaceutical products and services through the electronic environment are considered. Four methods of digital marketing that are affordable and cost effective for most pharmaceutical organizations have been identified. The relevance of direct contact with consumers through mobile applications and convenient multi-platform sites adapted to online sales, booking and delivery of pharmaceutical goods, pharmaceutical consumer consulting is shown. The results of opinion polls show average and high levels of consumer readiness to communicate with pharmacy organizations through digital technologies. The main limiting factor in the development of digital marketing methods in the pharmaceutical sector in the form of vague regulations is noted. The possibility of transition to full-fledged personalization of pharmaceutical care based on modern technologies has been determined.
DETERMINATION OF THE LEVEL OF KNOWLEDGE OF TEACHERS IN PROVIDING FIRST AID FOR ACUTE TOOTH TRAUMA
Authors: O.A. Malanova , N.S. Morozova , A.G. Maltseva
Published: May 2021

Aim: to evaluate the level of knowledge about dental trauma injury and first aid skills among teachers of educational institutions by means of a survey in Moscow, Russia. Materials and methods: A questionnaire, consisting of 4 parts and including 20 questions, including questions from the category of own experience in working with this problem, awareness of the problem of complete dislocation of the tooth, first aid skills and motivation for training. Several questions have multiple answers. The survey accepted 56 people from 1 educational institution. Results: the study indicated the knowledge level of teachers to be quite low. Early help reduces the risk of complications. The priority treatment provided within the educational institution will seriously affect the increase in the number of positive outcomes. Timely assistance, which can be provided by teachers from among the teachers of educational institutions, significantly reduces the risk of developing complications that can negatively affect the psychoemotional health of the child in adolescence. Early diagnosis, prophylaxis or treatment of dentate abnormalities at an early age help to avoid further progression of pathologies, save material means and time. Conclusions: the authors identified a lack of first aid skills in working with children who received an acute tooth injury, as a result of this, the need was revealed to train teachers of school educational institutions in theoretical and practical foundations for this group of pathologies, to conduct further clinical studies that will improve the epidemic situation around the world and in Russia in particular.
METHOD DEVELOPMENT FOR QUANTITATIVE ANALYSIS OF NITROPROSTON IN BIOLOGICAL FLUIDS AND ITS APPLICATION IN PHARMACOKINETIC STUDY
Authors: K.M. Shestakova , N.V. Mesonzhnik , N.E. Moskaleva , S.A. Appolonova , N.V. Pyatigorskaya
Published: May 2021

Nitroproston is an innovation multitarget pharmaceutical based on natural prostaglandin and dinitroglycerol moety. The drug was developed for treatment of obstructive diseases in lungs including asthma and obstructive bronchitis. The goal of the presented study was to develop and validate a method for quantitative analysis of nitroproston and its main metabolites in rabbit’s plasma and its application for pharmacokinetic study of the drug. Sample preparation contained liquid-liquid extraction with ethyl acetate. For the instrumental method there was chosen high performance liquid chromatography – mass spectrometric technique that allowed to perform a quantitative analysis of the drug with high rates of accuracy and selectivity. Validation of the developed method was assessed for such parameters as: selectivity, low limit of quantification, linearity, precision and accuracy, recovery, matrix effect and stability. The method was further applied for study of pharmacokinetic parameters of nitroproston and its metabolites in rabbit’s plasma. For this purpose, six rabbits were intravenously administered with nitroproston in the dose of 25 mg/kg, where other six rabbits represented control group. Plasma samples were taken in 2, 4, 6, 4, 8, 12, 18, 24, 32 and 60 minutes after.
Due to active biodegradation of nitroproston, the method was also validated for main metabolites of the drug that showed high levels of stability. As the result of the conducted validation, it was found that the method in valid for the assessed parameters. At the same time, Pharmacokinetic study of the metabolites showed that reliable profiles were received for 1,3-dinitroglycerol (first phase metabolite) and 13,14-dihydro-15keto-PGE2 (second phase metabolite).
INTRODUSING OF EFFICIENT PRODUCTION MANAGEMENT IN PHARMACEUTICAL COMPANIES
Authors: А.А. Khalimova , A.V. Kovalenko , V.V. Ugolnikov
Published: May 2021

The article analyzes the possibilities of applying the concepts of lean manufacturing, kaizen and 6 sigma in pharmaceutical production. The number of companies that use one or another productivity improvement system is increasing annually. The pharmaceutical sector is also actively involved in this process. Foreign companies such as Merck, Pfizer, Baxter and others have adopted various concepts of efficient production management since the beginning of the 21st century. In Russia, not only pharmaceutical companies, but also the state realized the need to implement such systems. Since 2010, many government programs and projects have been implemented to improve the efficiency of enterprises, expand them and increase exports. Some projects are focused only on the pharmaceutical industry (anti-epidemic projects, drug labeling, etc.), others - on certain industries (SPIC, labor productivity, labor productivity with RFRP). The "Labor Productivity" project is the only one that directly related to the implementation of lean production; in the rest, lean production can be implemented along with the implementation of the project's tasks. So, for example, the company AstraZeneca Industries Ltd did it, having carried out the localization of production in the Kaluga region under the SPIC project according to the Lean production principles. The article analyzes the activities of Russian companies that implement lean manufacturing tools under the national project "Labor productivity". The project participants are distributed in accordance with the types of products produced, by geography and the type of participation in the state program. The experience of the Werteks company, which introduced lean manufacturing tools with the participation of the Japan Association for Trade with Russia and Newly Independent States, was also studied.
SOCIO-PEDAGOGICAL DETERMINANTS OF THE FORMATION OF THE PERSONAL-PROFESSIONAL POSITION OF THE FUTURE TEACHER AS AN EDUCATOR
Authors: M.V. Shakurova , L.S. Arakelyan
Published: May 2021

In the situation of increasing attention of society and the state to the educational component of the educational process, the insufficient level of formation of the personal and professional position of teachers as educators is obvious. This position, along with competence, becomes one of the markers of the quality of professional training of future teachers. The role of educational institutions of higher education in the formation of the student's position as a future specialist is underestimated, which entails a number of deformations and negative consequences. The socio-pedagogical conditions that ensure the effectiveness of formative influences on the personal and professional development of future teachers as educators are also taken into account to an incomplete extent. The purpose of the study is to identify the socio-pedagogical determinants of the formation of the personal-professional position of future teachers as educators. Materials and methods: the paper uses the results of the analysis, generalization and systematization of domestic theories of education, professional education of future teachers. The most significant determinants are identified and ranked based on the results of a survey of students of the Faculty of Humanities of the Voronezh State Pedagogical University (83 students studying undergraduate and graduate programs). The basic methodological approaches are personal-activity and socio-pedagogical. As a result of the research, it is argued that the formation of the personal-professional position of future teachers as educators is a complex process in terms of meaning, content and activity. Its effectiveness is possible only in the presence of a wide range of socio-pedagogical conditions that provide it, the basic core of which is socio-pedagogical determinants. In accordance with the components of the personal and professional position, the most significant socio-pedagogical determinants of the formation of the personal-professional position of the future teacher are identified. Ranking the results of the selection of significant determinants by students allows us to conclude that certain components of the personal-professional position (value, target, ethical, reflexive) are underestimated by students due to insufficient attention to these aspects of professional training.
DYNAMICS OF SELF-RELATIONSHIP OF STUDENTS-PSYCHOLOGISTS IN THE PROCESS OF PROFFESIONALIZATION
Authors: E.A. Kolomiets , G.Y. Kolesnikova , I.V. Galaktionov
Published: May 2021

This article examines the problem of self-relationship of students-psychologists in the process of professionalization, on the basis of correlation and factor analysis is compared two groups of subjects of junior and senior courses with varying degrees of involvement in the professional activities of a psychologist, analyzes the causes and possible results of changes in self-relationship. The article established the following patterns: motivational and semantic mechanisms of self-development assume the impact on the personality of the future specialist through a change in the meaning of activity. Depending on the level of self-fulfillment of the individual, the appropriate dynamic semantic systems were allocated at different stages of the training. External negative motivation, as professionalization begins to correlate more strongly with both self-esteem and global self-relationship. This is a consequence of the abandonment of externally asked forms of activity in favor of the growth of self-determinized motivational tendencies. The role of external evaluation does not decrease, but the tolerance for being in a highly competitive environment increases. Negative external assessments activate the desire to confirm the level of global self-relationship. Factor analysis allowed us to identify an integral complex of "primary professionalization" that combines high resistance to external negative effects on self-esteem, high conceit, as well as professionally important for the psychologist traits of sensitivity and propensity to carefully analyze behavior. The impact on the formation of a professional psychologist during the course of training can be distinguished by how objectively they are, or perceived subjectively significant for students as controlling, informing or amotivating, how much weight their contribution to the formation of internal motivation of the individual. In particular, the study found that changes in self-relationship at different stages of professionalization lead to the development of sensitivity as a factor of empathy, a number of qualities become self-determinized depending on the degree of importance for the future profession.
ASSESSMENT OF THE MANIFESTATION OF EMOTIONAL STATES IN ATHLETES
Authors: E.S. Naboychenko , M.V. Noskova
Published: May 2021

One of the urgent problems in modern sports is the study of emotional states in athletes. This is due to the changing socio-economic conditions that affected sports activities. An increase in loads, high competition lead to a high level of stress and an increase in emotional stress. Emotions show the state of the athlete and his attitude to a particular sports situation. The article reveals the theoretical and practical aspects of the problem of emotional states of athletes. Emotional states are a set of psychophysiological phenomena, where, in addition to motor reactions, various changes appear in the course of processes and are associated with different manifestations of emotions. They are distinguished by individuality, polarity, variability, integrity. Criteria for emotional states are presented. The purpose of the research is to reveal the severity of manifestations of emotional states of athletes in the conditions of the training process. The study sample consisted of 1545 athletes aged 14-18 years, of which the share of boys was 68.5%, girls - 31.5%. It was carried out on the basis of GAUZ SO "Multidisciplinary Clinical Medical Center" Bonum ". Within the framework of the study, attention was paid to such indicators as: well-being, activity, mood, neuropsychic stability, interest, emotional tone, comfort. The conducted research allows us to make a conclusion. In general, athletes are dominated by mental well-being, positive emotional states, a desire to practice playing skills with enthusiasm and attention, with the manifestation of a cognitive need, good health, mood, sustained interest and concentration in the implementation of a sports game, full inclusion in the training process.
REFLECTION AS A PROFESSIONAL-IMPORTANT QUALITY OF AN ATHLETE: PROBLEM STATEMENT AND RESULTS
Authors: E.S. Naboychenko , M.V. Noskova
Published: May 2021

Abstract. The relevance of the study lies in the fact that recently it is possible to notice a trend in the popularity of sports, an increase in the requirements for athletes (high-quality performance of sports activities, functions, the ability to develop potential capabilities), which determine success in sports and competitiveness. The article discusses various factors that affect the effectiveness and success of an athlete: individual psychological characteristics of a personality, his professionally important qualities, motivational sphere, mental states, volitional efforts. Among the listed factors, reflection is of no small importance as one of the professionally important qualities of an athlete. The theoretical analysis of the psychological and pedagogical literature made it possible to conclude that reflection is an activity that must be trained, master its features and use in one's sports activity. It acts as a system-forming characteristic of the cognitive activity of an individual, which allows one to build new patterns of one's behavior, to develop certain knowledge. The study of the problems of reflection in sports has both theoretical and practical significance in sports psychology and pedagogy. The systematic manifestation of reflection by an athlete contributes to the development of reflexivity as a quality. As a result, his recognition of the planned actions on the playing field will allow him to plan his actions in this situation. The article presents a meaningful characteristic of different types and forms of reflection. The aim of the research is to determine the level and types of reflexivity in athletes. The study involved 1545 athletes - students of sports schools of the Olympic reserve, children and youth schools, national teams of the Sverdlovsk region, Masters of Sports, Candidates for Master of Sports, athletes with I, II, III categories at the age of 14-18 years.
Career advancement comparative perspective study of university lecturer
Authors: Kurniawati Maya , Saleh Choirul , Muluk M.R. Khairul
Published: May 2021

Globalization and international standard universities trend drive the higher education system to become more dynamic and innovative. The lecturer is a profession that drives and encourages university competitiveness. Therefore, better career advancement and development are vital in encouraging higher education competitiveness. The United States of America (USA) is currently a world-class university orientation, followed by Australia. Hence, other countries, especially developing countries, should know the USA and Australia higher education system, especially in the lecturers’ career advancement and development. This study is necessary to answer research questions about comparing academic career advancement systems in the USA and Australia. This study will give other countries new insight into academic career advancement. The researchers apply the findings from a systematic review. This study focuses on six aspects discussed: regulations, educational qualifications, lecturer obligation status in the higher education, career ladder, career advancement stages, and the lecturers' duties also responsibilities in lecturer career advancement in the USA and Australia. This study examines the gap between lecturers' career advancement systems in the USA and Australia comprehensively. The researchers observe by analyzing the strengths and weaknesses of the lecturer career advancement system in the USA and Australia. Also, the researchers compare the results using comparative public administration theory.