bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Absorbent-Enhanced Ammonia Separation For Efficient Small Scale Ammonia Synthesis
Authors: Onuoha C. Emmanuel , Kale Matthew , Malmali Mahdi , Dauenhauer Paul , McCormick Alon
Published: October 2023

Synthesized ammonia exiting a reactor with hydrogen and nitrogen can be selectively absorbed by MgCl2 for renewable absorbent-based Haber Bosch for dispersed ammonia manufacturing. Such separation can be more efficient even at elevated temperatures compared to the condensation method used in conventional Haber Bosch process. To determine the optimal conditions to capture and release the most ammonia per thermal cycle of sorbent salt, the sorbent capacity was measured with varying regeneration temperature, regeneration time, and sweep rate under steady-state cycling conditions. In all cases, uptake was limited to bed breakthrough, and cyclic steady state was achieved. By using lower temperature for MgCl2 regeneration (200 °C), the working capacities were maintained comparable to those at higher desorption temperatures (~ 400 ⁰C), even without the use of inert sweep gas. Using a sufficiently high regeneration temperature (~200 ⁰C) allowed for sufficiently low sweep gas that the product ammonia can exceed 72 mol% purity in a mixture of N2 and H2. These results were achieved with a short regeneration time of 20 minutes or less, which is an improvement from hour-long regeneration time previously reported. These measurements identified new operating parameters for more efficient absorber design to produce economical renewable ammonia at small scale.
High-throughput large scale microfluidic assembly of iron oxide nanoflowers@PS-b-PAA polymeric micelles as multimodal nanoplatforms for photothermia and magnetic imaging
Authors: Benassai Emilia , Hortelao Ana C. , Aygun Elif , Alpman Asli , Wilhelm Claire , Ulku Saritas Emine , Abou-Hassan Ali
Published: October 2023

Magnetic nanoparticles have been extensively explored as theranostic agents both in academic and clinical settings. Their self-assembly into nanohybrids using block copolymers can lead to new nanostructures with high functionalities and performances. Herein, we demonstrate a high-throughput and scalable method to elaborate magnetic micelles by the assembly of iron oxide magnetite nanoflowers, an efficient nanoheaters, and an the block copolymer Poly(styrene)−block−poly(acrylic acid) via a microfluidic-assisted nanoprecipitation method. We show that the size and shape of the magnetomicelles can be easily tuned by modulating the residence time in the microfluidic channel. In addition to their biocompatibility, we demonstrate the potential of these magnetic nanohybrids as multimodal theranostic platforms capable of generating heat by photothermia and functioning as negative contrast agents in magnetic resonance imaging and as imaging tracers in magnetic particle imaging. Notably, they outperform currently commercially available particles in terms of imaging functionalities.
Self-assembled Tetrahedral Iron(III) Cage for MRI Guided Delivery of a Gold Drug
Authors: Sahoo Priya , Turowski Steven , Spernyak Joseph , Morrow Janet
Published: October 2023

A T1 MRI probe based on a self-assembled tetrahedral iron(III) cage acts as a host for a gold(I) anticancer drug, which is added as Au(PEt3)Cl. 1H NMR characterization of the gold complex within the Ga(III) analog of the tetrahedral cage is consistent with loss of chloride to give a mixture of Au(PEt3)(OH2) and Au(PEt3)(OH) within the cage. This aqua species may be converted to encapsulated Au(PEt3)CN by treatment with KCN. The binding constant of the gold aqua complex is estimated as ≈ 103 M-1 by displacement experiments with various ammonium cations. Studies show that the iron cage with encapsulated gold complex binds tightly to serum albumin and that there is little dissociation of iron or gold complexes over 24 hours. The iron-gold host-guest complex shows enhanced contrast of the vasculature, consistent with strong binding of the cage to serum proteins. Uptake of the iron cage into C26 tumors as shown by MRI corresponds to the deposition of gold as measured by ICP-MS. These data suggest that the tetrahedral iron cage may serve as a host and carrier for gold drugs towards applications as theragnostic agents.
Automatic Rhodopsin Modeling with Multiple Protonation Microstates
Authors: Cardenas Gustavo , Ledentu Vincent , Huix-Rotllant Miquel , Olivucci Massimo , Ferré Nicolas
Published: October 2023

Automatic Rhodopsin Modeling (ARM) is a simulation protocol providing QM/MM models of rhodopsins, capable of reproducing experimental electronic absorption and emission trends. Currently, ARM is restricted to a single protonation microstate for each rhodopsin model. Herein, we incorporate an extension of the minimal electro- static model (MEM) into the ARM protocol to account for all relevant protonation microstates at a given pH. The new ARM+MEM protocol determines the most impor- tant microstates contributing to the description of the absorption spectrum. As a test case, we have applied this methodology to simulate the pH-dependent absorption spec- trum of a toy model, showing that the single microstate picture breaks down at certain pH values. Subsequently, we applied ARM+MEM to Anabaena Sensory Rhodopsin, confirming an improved description of its absorption spectrum when the titration of several key residues is considered.
A Molecular Cu Electrocatalyst Escalates Ambient Perfluorooctanoic Acid Degradation
Authors: Sinha Soumalya , Chaturvedi Ashwin , Gautam Rajeev , Jiang Jianbing
Published: October 2023

Groundwater reservoirs contaminated with per- and polyfluoroalkyl substances (PFASs) need purifying remedies. Perfluorooctanoic acid (PFOA) is the most abundant PFAS in drinking water. Although different degradation strategies for PFOA have been explored, none of them disintegrates the PFOA backbone rapidly under mild conditions. Herein, we report a molecular copper electrocatalyst that assists in the degradation of PFOA up to 93% with 99% defluorination rate within 4 h of cathodic controlled-current electrolysis. The current-normalized pseudo-first-order rate constant has been estimated to be quite high for PFOA decomposition (3.32 L h–1 A–1), indicating its fast degradation at room temperature. Furthermore, comparatively rapid decarboxylation over the first 2 h of electrolysis has been suggested to be the rate-determining step in PFOA degradation. The related Gibbs free energy of activation has been calculated as 22.6 kcal/mol based on the experimental data. In addition, we did not observe the formation of short-alkyl-chain PFASs as byproducts that are typically found in chain-shortening PFAS degradation routes. Instead, free fluoride (F–), trifluoroacetate (CF3COO–), trifluoromethane (CF3H), and tetrafluoromethane (CF4) were detected as fragmented PFOA products along with the evolution of CO2 using gas chromatography (GC), ion chromatography (IC), and gas chromatography-mass spectrometry (GC-MS) techniques, suggesting comprehensive cleavage of C–C bonds in PFOAs. Hence, this study presents an effective method for rapid degradation of PFOA into small ions/molecules.
A Case Report on Alcohol Dependence Syndrome with Relation to Insomnia
Authors: S H Fiza , Shetty Prajnesh J , George Robin
Published: October 2023

Alcohol dependence is a pattern of substance use, leading to clinically significant impairment or distress; chronic alcohol abuse has been known to disrupt the normal sleep cycle and lead to sleep disorders, including sleep terror disorder. A male patient of age 42 years was a known alcoholic for 24 years, and the patient does not have any previous psychiatric history. Then, he stopped drinking for four days and developed insomnia. The patient gave an account of emotional outbreaks from 2 days; vital signs included blood pressure 140\90 , pulse rate 81 bpm, respiratory rate 20 , and oxygen saturation 97%@RA and the patient's GRBS level was 210 mg\, and the patient was immediately given with medication in. 4mg (IV), . (2 amp in 100 ml NS, BD), . Panto 40mg (IV), the same drug, was continued for three days, and there was no complaint of visual hallucinations. The patient felt symptomatically better and was discharged on the 4th day with no fresh complaints. The patient was advised to continue Tab. 2mg for three days. The preliminary case investigation evaluated the link between insomnia and alcohol dependence syndrome (ADS).
Hubungan Masa Kerja dan Paparan Pestisida terhadap Kadar Cholinesterase Petugas Penyemprot di Perkebunan Kelapa Sawit
Authors: Himayati Himayati , Susilowati Indah Tri
Published: October 2023

Pestisida adalah salah satu hasil teknologi modern dan mempunyai peranan penting dalam meningkatkan kesejahteraan rakyat. Sebagian besar cara penggunaan pestisida oleh petani adalah dengan cara penyemprotan. Saat penyemprotan merupakan keadaan dimana petani sangat mungkin terpapar bahan kimia yang terdapat dalam pestisida yang digunakan. Bahaya yang dapat terjadi saat penyemprotan tersebut dapat mengakibatkan gangguan yang menyebabkan penyakit. Salah satu parameter untuk mengetahui terjadinya keracunan pestisida adalah menurunnya aktivitas enzim Cholinesterase. Tujuan penelitian ini untuk mengetahui ada atau tidaknya hubungan antara lama masa kerja dan lama paparan pestisida terhadap kadar cholinesterase darah petugas penyemprotan di PT. X Jambi. Jenis penelitian ini observasional analitik, untuk pengambilan sampel dilakukan di perkebunan kelapa sawit PT. X Jambi. Pemeriksaan kadar cholinesterase darah diperiksa di pusat rujukan nasional Prodia Jakarta dengan metode Tes fotometri kinetic. Hasil pengukuran kadar cholinesterase dalam darah dari 43 responden didapatkan hasil dalam batas normal. Uji koreksi pearson product moment menunjukkan bahwa tidak ada hubungan antara lama masa kerja dan lama paparan pestisida terhadap kadar cholinesterase darah petugas penyemprot PT. X Jambi.
Microbiological Test and Antioxidant Activity of Moringa Leaf Brownies Substituted with Tempeh Flour which is High in Protein for Anemic Pregnant Women
Authors: Nugroho Arie , Sutrio Sutrio , Sari Adinda Juwita , Kusdalinah Kusdalinah
Published: October 2023

Brownies are food, a distraction loved by all class ages. Most study regarding the added brownies' and other material shows that the product experience organoleptic changes and does not increase mark nutrition, including antioxidants. This study test marks microbiology and activity of leaf brownies antioxidants moringa substituted flour tempeh. This is the advanced study year, the second which brownies are the most liked, and the control will be compared in a manner mark microbiology and activity antioxidants. The research method in this study is draft random complete (RAL) with five replications. Leaf moringa, added to making these brownies, is porridge leaf moringa obtained from fresh leaf moringa, as much as 10% of the total flour. Treatment consisted of different composition bases comprising brownies from flour wheat compared flour tempeh with substitution tempeh flour, which is 100:0 (A1) and 75:25(A3), the most preferred panelist from the previous study. Good brownies products it controls, and A3 have marked microbiology following SNI standards to consume them safely. Activity value antioxidants from A3 are taller compared to controls. Recommended brownies products using leaf moringa as additional toppings to minimize decline activity antioxidants because of the oven.
Preferences among Pregnant Women in Choosing a Private Midwife Practice as Service Provider for Antenatal Care (ANC)
Authors: Fatriani Rully , Risneni Risneni
Published: October 2023

Antenatal Care (ANC) is essential in achieving a healthy pregnancy. During the pandemic, pregnant women tended to carry out ANC in private midwife practice. The reasons for pregnant women choosing private midwife practice might differ for each individual. This study aims to describe the preference of pregnant women in choosing private midwife practice as a service provider for ANC. This research is a quantitative observational descriptive. The population was pregnant women who performed ANC at a private midwifery practice in Bandar Lampung City from June to July 2023. Eighty-eight samples obtained by accidental sampling met the inclusion criteria and expressed consent to participate. The instrument used was a questionnaire, and data was analyzed using univariate. It was found that preferences of pregnant women in choosing private midwife practice as ANC provider were more experienced midwives (27.3%), previous pregnancy history (22.7%), friendly midwives (18.2%), distance (13.6%), recommended by husband or relatives (9.1%), more affordable costs (4.5%), comfort and complete facilities (4.5%). To increase the number of ANC visits, midwives must pay attention to increasing competency in midwifery care, improving their personality, and providing the facilities pregnant women need.
Changes in Assessment Modality in Saudi Higher Education: Lessons Learnt Post-COVID-19
Authors: Mohamed Wessam , Almuqayteeb Taghreed Abdulaziz
Published: October 2023

This article examines the changes in academics' assessment practices, the contributing variables in response to the transition to the online modality during the pandemic, and the most important 21st-century skills that academic programs should assess post-COVID. The study used a descriptive methodology with both quantitative and qualitative analyses via survey-based research. A total of 225 faculty members from different academic clusters, of different educational levels, genders, and assessment-related work experiences completed the questionnaire. The findings of this research identified interesting shifts in the academics' assessment practices upon 100% transition to the online modality. Specifically, most of the academics modified their assessment plans by lowering the workload of assessment tasks while retaining the same assessment methods. Additionally, a higher weightage of marks was allocated to the use of alternative/ authentic assessment. There was a noticeable increase in the employment of online assessment methods such as examinations, oral exams, assignments, and participation. Furthermore, both the academic cluster and course type had impacts on the utilization of online assessment methods. Lastly, the study identified critical thinking and problem-solving skills, information and computer technology-related skills, and creativity as the top skills to be assessed post-COVID-19. By examining the academics' assessment practices in response to the complete transition to the online modality, this research contributes to the sustainability of best practices in online assessment modalities in higher education. Finally, this study provides recommendations for academics: collaborative assignments, valued as a high-impact assessment practice, should be used to embed and sustain learning. Additionally, academics should be encouraged to adopt authentic assessment methods for online assessment.
A 95% decline in estimated newly acquired HIV infections, Amsterdam, 2010 to 2022
Authors:   The HIV Transmission Elimination AMsterdam (H-TEAM) Initiative
Published: October 2023

The infrastructure in cities provides unique opportunities to eliminate HIV. Since 2014, the HIV Transmission Elimination AMsterdam Initiative, a consortium involved in HIV prevention and care, has employed an integrated approach to curb HIV incidence in Amsterdam. This effort contributed to the 95% decline in estimated newly acquired infections and the 79% decline in observed new HIV diagnoses in Amsterdam from 2010 to 2022. In 2022, Amsterdam reached and exceeded the 95–95–95 UNAIDS treatment cascade goals (98–95%-96%).
DATA PROTECTION AT THE STAGES OF ITS FUNCTIONING
Authors: Akhramovych Volodymyr
Published: October 2023

Today, computer and information technologies have covered all areas of the economy. For any modern company, information becomes one of the main resources, the preservation and proper management of which is of key importance for business development and reducing the level of various risks. Ensuring information security is an urgent problem today.

Methods of data security depend, among other things, on the state of the data. Taking into account what was said in the article, an attempt was made to consider the methods of data security depending on the data states (data at rest; data being transmitted; used data).

So, for example, the state of inactive data (state of rest) is characterized by methods of security: in the form of the use of various encryption methods, access rights management, for example, such as SealPath, the use of MDM tools (they allow you to limit access to certain corporate programs, block access to a device or encrypt data on a mobile phone or tablet), DLP (data leakage prevention), CASB (cloud access security brokers): These are systems that allow us to apply security policies to the documentation we have in cloud systems, for example, such as Office 365, Box, Salesforce, etc.

For the state of the transmitted data, typical methods of security in the form of application: encryption of e-mail; managed file transfer, such as MFT technology; DLP technologies provide protection because they can detect if sensitive data is being sent outside the organization; CASB (Cloud Access Security Brokers): refers to data transmitted by an untrusted user for this type of data), it may be blocked for download; SealPath technologies; etc.

For the state of the data used, the typical methods of security in the form of application: in a successful case, digital rights protection technologies or IRM are recommended, which is one of the most effective means of data protection, because it combines encryption + permission management + identity control. This security allows documentation to be stored safely in its three states and tracked in any state sequentially.
SYNERGIC APPROACH BASED ASSESSMENT OF BUSINESS-PROCESSES CONTINUITY
Authors: Zviertseva Nataliia
Published: October 2023

Informational threats can manifest themselves in different forms, which is due to the features of the global network. The article is devoted to one of the ways of solving the contradiction, which is that, despite the large number of publications, the task of ensuring the continuity of business processes in the conditions of the growing number and variety of cyber attacks on critical infrastructure objects remains unresolved. This is due to the constant modification and increase in the number of cyber attacks, as well as methods and technologies for implementing business processes. Therefore, the development and improvement of methods for assessing the continuity of business processes is an urgent scientific task. The article examines the problem of ensuring the continuity of business processes in the conditions of the growth of cyber threats. The means and methods of committing cybercrimes against critical infrastructure facilities were analyzed. The main strategies and business continuity assessment indicators are defined. The influence of selected strategies and solutions for ensuring business continuity on the value of business process continuity indicators is analyzed. The main trends in the development of cyber security in the context of improving the means and methods of carrying out terrorist information attacks on critical infrastructures are analyzed. Preventive measures to reduce the risk of cyberattacks at the national and international levels have been identified.

The main tasks of ensuring the continuity of business processes based on the PDCA risk management model, indicators for assessing business continuity are considered. The influence of the selected strategies and solutions on ensuring the continuity of business processes is analyzed.
DEVELOPMENT OF SECURE CONTAINERIZED APPLICATIONS WITH A MICROSERVICES ARCHITECTURE
Authors: Spasiteleva Svitlana , Chychkan Ivan , Shevchenko Svitlana , Zhdanovа Yulia
Published: October 2023

The article analyzes approaches to software development that allow creating complex container applications with a microservice architecture based on automation tools and flexible development methods. The development of cloud technologies, the global strategy of containerization, the modernization of the application architecture, and the increase in security requirements have led to a change in the application development methodology. The study aims to determine approaches to increase the speed of development, security and quality of software code of containerized applications by implementing security principles and automation tools at all stages of the life cycle. Features and development prospects of microservice applications deployed in a container environment are considered. The advantages of the container infrastructure are defined: mobility, scalability, an additional level of microservice security. Containers provide an isolated environment for running a microservices, this reduces the risk of security vulnerabilities and simplifies interaction between microservices. The article identifies the security problems of microservice applications and the main vulnerabilities associated with the use of containers. It is determined that DevSecOps methodology allows implementing modern practice of continuous integration, continuous delivery, continuous application deployment and integration of security tools at all life cycle stages. DevSecOps describes development processes, deployment and operation processes using Security as Code and Infrastructure as Code practices. The research describes the model for developing and deploying microservice applications with containerization, defines the security domains, and the security controls for DevSecOps development pipeline. Based on this model, the main security control tools that must be used at all development and deployment pipeline stages are defined. The article proves that the considered technique regulates the implementation of given security procedures at all stages of the pipeline, allows to reduce development time and improve code quality for container applications with a microservices architecture.
Âşık Abdil’in şiir evreninde dinî tasavvur ve didaktik söylem
Authors: KIRMIZI Ömer , GÖNEL SÖNMEZ Tugba
Published: October 2023

Kökenini ve ilhamını İslamiyet öncesi sözlü şiir geleneğinden alan ve yüzyıllardır içinde bulunduğu sosyokültürel şartlara göre şekillenip gelişen âşıklık geleneği, günümüzde icra ortamlarının değişmesiyle özüne bağlı kalmakla beraber kendini güncellemektedir. Geleneğin bu yüzyıldaki durumunun tespit edilmesinde yaşayan âşıkların ve eserlerinin incelenmesi önem arz etmektedir. Bu bağlamda Silifkeli Âşık Abdil, çalışmamızın odak noktasını oluşturmaktadır. Âşık Abdil, yaşadığı yörenin sosyokültürel şartlarından ötürü çocukluk çağlarından itibaren şiirle meşgul olmuş, usta-çırak geleneği içerisinde yetişmemesine rağmen geleneğin güçlü temsilcilerini okuyarak öğrenmiş ve onları kendisine usta kabul etmiştir. Müzik aleti olarak kaval çalan âşık; Uzun Mehmet, Âşık Ali, Kara Fevzi ve Âşık Velittin gibi âşıklarla yakın ilişkiler geliştirmiş, aynı meclislerde bulunarak atışmalar yapmıştır. Çalışmamızda, Âşık Abdil’in literatür taraması ile saha araştırmasından hareketle tespit edilen şiirlerinde yer alan dinî muhteva unsurları, biyografik bağlamından hareketle ele alınmış; şiir evreninden dörtlüklerle örneklendirilmiştir. İçerik incelemesi temelinde tespit edilen dinî temalar, âşık edebiyatı şiir geleneği bağlamında metin merkezli bir bakış açısıyla biyografik bağlam dikkate alınarak değerlendirilmiştir. Günümüz âşıklık geleneğinin mahallî temsilcilerinden biri olan Abdil’in sanatını çağdaş terim, kavram ve konularla güncelleyerek geliştirdiği görülmektedir. Âşığın ilk şiirlerinde görülen lirik anlatım ve buna bağlı kullanılan aşk, ayrılık, eleştiri ve doğa sevgisi gibi temaların, aşığın olgunluk dönemine erişmesi ile birlikte yerini didaktik bir üsluba ve iman, ibadet, ahiret inancı, Allah ve peygamber sevgisi, cennet, cehennem, dua ve teslimiyet gibi dinî temalara bıraktığı tespit edilmiştir. Sonuç olarak âşığın şiirlerinde tasavvufi neşveye rastlanmasa da onun şiirlerinde derin bir manevi arayış, Allah’a olan sevgi ve bağlılığın sıklıkla ele alındığı görülmektedir.
LA REPARACIÓN INTEGRAL DE LA VÍCTIMA FRENTE A LA APLICACIÓN DE LA SUSPENSIÓN CONDICIONAL DE LA PENA
Authors: Laverde Samuel , Gamboa Vargas Sabina Lorena , Galarza Castro Christian Xavier
Published: October 2023

El problema en la presente investigación, se determina en qué, al verificarse que no existe una ejecución forzosa en materia penal, se debe acudir a la norma supletoria, lo que podría afectar a la eficiencia en el cumplimiento de la reparación integral, por esto es trascendental, analizar los estándares de convencionalidad desarrollado por los instrumentos internacionales, a fin de verificar si se cumple los mismos en la normativa interna y se pueda verificar la eficacia en el cumplimiento de la reparación integral. En cuanto al objetivo que se pretende alcanzar con la presente investigación, es analizar la ley y la jurisprudencia de la Corte IDH como fuentes formales del Derecho, para garantizar la reparación integral de las víctimas en materia penal frente a la aplicación de la suspensión condicional de la pena. La metodología se configura, en el enfoque cualitativo, de carácter descriptivo documental. Porque se llevará a cabo la interpretación sistemática de la norma, así como los estándares jurisprudenciales desarrollados a nivel judicial, constitucional y convencional. Se obtuvieron los siguientes resultados: En cuanto a la normativa, no existe una caución que pueda garantizar debidamente su pago. En cuanto a la rapidez, no se reconoce como expedito porque no existe un límite tempo para el cumplimiento de la reparación integral, como condición de la suspensión condicional de la pena.

 

Palabras clave: Reparación integral, víctima, suspensión condicional, eficiencia, estándares de convencionalidad.
“The First White Mother in America” Guðríðr Þorbjarnardóttir, Popular History, Firsting, and White Feminism
Authors: Crocker Christopher
Published: October 2023

This article takes Ásmundur Sveinsson’s statue "The First White Mother in America" as a starting point. With reference to this work, its several later casts, and three illustrative examples from recent popular history writing, the article demonstrates how popular representations of the statue's subject, Guðríðr Þorbjarnardóttir, frequently reinforce traditions rooted in racially exclusive historical standards and Indigenous erasure. While Guðríðr’s story offers a valuable counterpoint to male-dominated and often hyper-violent images of “Viking” history, writers and other popular history purveyors depicting her story also run the risk of simultaneously reinforcing settler-colonial and white supremacist ideals regardless of their individual motives.
A Comprehensive Bibliometric Analysis of Deep Learning Techniques for Breast Cancer Segmentation: Trends and Topic Exploration (2019-2023)
Authors: Agus Perdana Windarto  , Anjar Wanto  , S Solikhun  , Ronal Watrianthos
Published: October 2023

The objective of this study is to perform a comprehensive bibliometric analysis of the existing literature on breast cancer segmentation using deep learning techniques. Data for this analysis were obtained from the Web of Science Core Collection (WOS-CC) that spans from 2019 to 2023. The study is based on a comprehensive collection of 985 documents that cover a substantial body of research findings related to the application of deep learning techniques in segmenting breast cancer images. The analysis reveals an annual increase in the number of published works at a rate of 16.69%, indicating a consistent and robust increase in research efforts during the specified time frame. Examining the occurrence of keywords from 2019 to 2023, it is evident that the term "convolutional neural network" exhibited a notable frequency, reaching its peak in 2021. However, the term "machine learning" demonstrated the highest overall frequency, peaking around 2021 as well. This emphasizes the importance of machine learning in the advancement of image segmentation algorithms and convolutional neural networks, which have shown exceptional effectiveness in image analysis tasks. Furthermore, the utilization of latent Dirichlet Allocation (LDA) to identify topics resulted in a relatively uniform distribution, with each topic having an equivalent number of abstracts. This indicates that the data set encompasses a diverse range of topics within the field of deep learning as it relates to breast cancer image segmentation. However, it should be noted that topic 4 has the highest level of significance, suggesting that the application of deep learning for diagnosis was extensively explored in this study.
Efektivitas Minyak Kemiri (Aleurites moluccana L.) sebagai Penumbuh Rambut pada Tikus (Rattus norvegicus)
Authors: Miftahurahma Nabila Martha Ludi , Andriyanto  , Manalu Wasmen , Ilyas Abdul Zahid
Published: October 2023

Rambut memiliki fungsi proteksi dan fungsi estetika sebagai penunjang penampilan. Rambut rontok merupakan masalah yang banyak dijumpai dan mengakibatkan kebotakan. Kebotakan dapat dicegah dengan produk sintetis maupun herbal, namun produk sintetis dapat menimbulkan efek samping. Minyak kemiri mampu menjadi alternatif pengobatan karena terbuat dari bahan alam dan aman digunakan. Penelitian ini bertujuan menguji efektivitas minyak kemiri sebagai penumbuh rambut. Kelompok perlakuan terdiri atas kelompok kontrol tanpa pengolesan (A), kelompok dengan pengolesan sekali sehari (B), kelompok dengan pengolesan dua kali sehari (C), dan kelompok dengan pengolesan tiga kali sehari (D). Panjang rambut diukur dan uji iritasi dilakukan pada hari ke-6, 9, 12, dan 15 setiap hari secara topikal pada bagian punggung tikus yang telah dicukur. Hasil penelitian menujukkan bahwa minyak kemiri memiliki efektivitas sebagai penumbuh rambut. Uji efektivitas minyak kemiri sebagai penumbuh rambut secara statistik memperlihatkan pertumbuhan rambut yang lebih cepat dibandingkan kontrol pada frekuensi pengolesan tiga kali sehari dan tidak berbeda nyata  dibandingkan dengan pengolesan satu kali dan dua kali sehari. Uji iritasi menunjukkan tidak terdapat iritasi pada punggung tikus.
Left ventricular diastolic dysfunction and transmitral blood flow parameters in patients after COVID-19
Authors: Vasilev V. A. , Karapetyan T. T. , Larionova V. A. , Solyanikova I. N. , Tsekhanovich K. B.
Published: October 2023

Background. People who previously had COVID-19 infection have an increased risk of developing cardiovascular diseases. Left ventricular diastolic dysfunction is an early marker of the development of cardiac pathology. Its early detection is important for the adequate therapy order and dynamic monitoring of patients. In this regard, it seems relevant to study the effect of a recent COVID-19 infection on the left ventricular diastolic function and transmitral blood flow parameters in apparently healthy individuals without clinical and instrumental signs of cardiovascular pathology. The aim of the study. To assess the changes in the diastolic and systolic function of  the left ventricle, its anatomical parameters and transmitral blood flow parameters in two groups of  apparently healthy individuals: those who had and those who had not COVID-19 infection. Materials and methods. Transthoracic echocardiography was performed according to the standard technique and its results were analyzed in 66 examined patients who were recognized as apparently healthy according to the results of  regular comprehensive clinical and instrumental studies. The first group included 30 individuals who underwent an echocardiographic study before or during the COVID-19 pandemic, but did not have a coronavirus infection; the second group consisted of 36 people who recovered from COVID-19. The indicators of the presence of left ventricular diastolic dysfunction and the transmitral blood flow parameters were assessed. The study was approved at a meeting of the Medical Ethics Committee under the Ministry of Health of the Republic of Karelia and of Petrozavodsk State University (Minutes No. 47 of 01.11.2023). Results. The frequency of the left ventricular diastolic dysfunction did not differ in  the  first and second groups of patients. Statistically significant differences were recorded in the average flow deceleration time for both early and late filling of the left ventricle in people who had and did not have COVID-19 infection. A change in the phase structure of the transmitral blood flow may be an early manifestation of intracardiac hemodynamic disorders in people who have recovered from COVID-19.
Current concepts of Peyronie’s disease (clinical lecture)
Authors: Lelyavin K. B.
Published: October 2023

The article is presented in the format of a lecture. Peyronie’s disease (induratio penis plastica) is a progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and  can cause penile deformity. The issues of  etiology, pathogenesis, clinical picture and diagnosis of Peyronie’s disease (PD) are reviewed in the lecture from the modern points of view. PD is frequently associated with penile pain, erectile dysfunction, and a secondary anxiety-depressive state. Despite the existence of this problem for several centuries, no unified concept of the Peyronie’s disease pathogenesis can be found in literature. A growing amount of research has shown that PD is a chronical disorder of local wound healing process within the tunica albuginea and the Smith’s space. Over the past 40 years, multiple lines of evidence have pointed to a genetic factor that predisposes some men to the development of Peyronie’s disease. Treating men with PD remains a challenging problem for clinicians working in urology. Given the high prevalence of PD and its significant impact on affected men, its better understanding is essential. Treatment methods for PD are varied and include oral, local, intralesional and traction therapy, and surgical treatment. Current clinical care standards for PD are aimed at the symptom suppression, as there are currently no treatment for PD that can eliminate its causes or progression. Clostridium histolyticum collagenase has shown its effectiveness in  treating PD, but its efficacy and safety remain controversial. Surgery remains the most effective method for PD treatment and is considered to be “gold standard”. The choice of the  surgical technique depends on the length of the penis, degree of deformity, erectile function, patients’ expectations and surgeon’s preferences. Various surgical techniques and grafting materials (autologous and non-autologous) can  be used for  the coverage of  the tunica albuginea defect after partial plaque excision or incision.
Modern anatomical and physiological bases for maintaining the transparency of the corneal stroma
Authors: Krasner K. Yu. , Poveshchenko O. V. , Surovtseva M. A. , Trunov A. N. , Kim I. I. , Bondarenko N. A. , Chernykh V. V.
Published: October 2023

The article presents a literature review of the modern concept of anatomical and physiological structure and functioning of the cornea. The strict morphological structure and corneal tissue homeostasis ensure its transparency. Studying the mechanisms that regulate the constancy of the corneal tissue internal environment allows us to get closer to understanding the prospects forregenerative therapy for the corneal stroma pathology. The article discusses in detail the role and functional potential of corneal stromal cells, which are capable of reverse cytologic differentiation, which primarily ensures the maintenance of tissue homeostasis and corneal transparency. The functional activity of corneal cells can change for a number of reasons, which may be exogenous, iatrogenic (trauma, infection, etc.) or endogenous. Endogenous causes include: cell autoregulation pathologies (for example, enzyme defects); defects in transport systems leading to tissue hypoxia; disorders of the neuro-humoral regulation of trophism. The physical reason forthe violation of the corneal transparency is an increase in the light scattering. The article presents five main causes of increased light scattering in the opaque cornea, and also provides an overview of the main substances – components and products of cellular synthesis of corneal stromal cells: cytokines and growth factors (complex of the signal molecule and the SDF1/CXCR4 receptor, insulin-like growth factor 1, tumor necrosis factor alpha, intercellular adhesion molecule 1, erythropoietin, neurotrophic factors, etc.). Thus, corneal opacity can be caused by a single pathogenic mechanism or be the result of a complex effect of several factors. The main processes of tissue homeostasis regulation are aimed at maintaining the unique morphological structure of the cornea.
Intersystem interactions of physiological system indicators in students with different types of autonomic regulation
Authors: Maltsev V. P. , Govorukhina A. A. , Malkov O. A.
Published: October 2023

Studying not only individual students indicators of students, but complex intersystem interactions that reflect the specifics of adaptive capabilities is of scientific interest. The aim of the study. To reveal the features of intersystem interactions of indicators of the blood vessels functional state, morphological and neurodynamic characteristics of students with different types of autonomic regulation, living in the KhantyMansiysk Autonomous Okrug – Yugra. Methods. 429 first–fourth-year students (348 girls, 80 boys) of the Surgut State Pedagogical University were examined. The initial type of autonomic regulation was determined by the average duration of electrocardiogram RR intervals. Anthropometry parameters (body length and weight) and body composition were assessed using Tanita BC-601 device (Tanita, Japan), vascular wall elasticity – using AngioScan-01 (AngioScan-Electronics Ltd, Russia), neurodynamic indicators – using NS-PsychoTest device (Neurosoft, Russia). Statistical analysis was carried out using Statistica 7.0 software (StatSoft Inc., USA). We used the nonparametric Mann – Whitney U-test to evaluate differences and the nonparametric Pearson R-test to analyze correlations. Results. An increase in the stiffness of the vascular wall of large and small arteries in girls is  accompanied by an increase in parasympathetic activity. In young men, an  increase in the stiffness of large arteries raises with an increase in sympathoadrenal activity, while a  compensatory increase in the stiffness of small muscular arteries is noted with an increase in parasympathetic activity. In persons with the sympathicotonic type of autonomic regulation, an excess content of fat mass, an increased frequency of visceral obesity, and a deficiency in water content were registered. With the predominance of the parasympathetic component contribution to the regulation of cardiac rhythm, an increase in the processes of inhibition in the central nervous system was noted. In young men, reduced sensorimotor reactions are consistent with sympathetic activation in the regulation of heart rate. Correlation analysis made it possible to establish some features in the interaction of the vascular, morphological and central nervous systems. Conclusion. Differences in indicators of functional systems (physical development, blood flow, neurodynamic characteristics) in the examined groups of students are  shown, taking into account gender and autonomic regulation type. Features of intersystem interactions of indicators of physiological systems of students’ bodies with different types of autonomic regulation were revealed.
PERANCANGAN APLIKASI ABSENSI PEGAWAI PADA PT AVIA JAYA INDAH
Authors: Munir Syirojul , Santoso Dwi Putro Mega , Rivandi Arfans Rivandi
Published: October 2023

Sistem Informasi adalah suatu kombinasi dari orang, perangkat keras, perangkat lunak, jaringan komunikasi  dan basis data yang menyebarkan informasi di dalam suatu bentuk organisasi. Sistem absensi merupakan hal yang terpenting di lingkungan PT Avia Jaya Indah untuk merekap kehadiran pegawai. Absensi dapat diartikan sebagai sebuah tanda kehadiran seseorang yang dimana nantinya hasil absensi akan dibuat menjadi sebuah laporan kehadiran. Seperti halnya pada PT Avia Jaya Indah masih menerapkan absensi manual dengan metode tanda tangan pada lembaran absen. Kelemahannya sering terjadi kecurangan, lupa absen, sehingga sering terjadi kesalahan. Aplikasi absensi dengan barcode salah satu solusi memanfaatkan teknologi informasi yang mampu menangani masalah diatas. Metode pengembangan yang digunakan dalam system ini menggunakan Model waterfall, bahasa pemograman yang digunakan memakai PHP dengan database MySQL. Adanya sistem informasi ini sangat membantu suatu perusahaan dalam pendataan gaji karyawan secara cepat dan akurat. Hasil dari rancang bangun ini adalah absensi berbasis web untuk PT Avia Jaya Indah
E-RAPOR PADA SEKOLAH DASAR NEGERI CAWANG 09 JAKARTA BERBASIS WEB
Authors: SUYATNO SUYATI
Published: October 2023

Abstrak – Kurikulum di Indonesia sudah mengalami perkembangan sejak periode sebelum tahun 1945 hingga kurikulum tahun 2006 yang berlaku sampai akhir tahun 2012 dan kemudian Kurikulum 2013 merupakan kurikulum yang baru diterapkan oleh pemerintah untuk menggantikan Kurikulum Tingkat Satuan Pendidikan. Disisi lain dengan perkembangan teknologi, setiap sekolahpun dituntut untuk menerapkan teknologi komputer demi meningkatkan mutu sekolah. Manfaat internet salah satunya adalah pembuatan sistem informasi e-rapor berbasis web pada SDN Cawang 09 Jakarta karena pengolahan nilai dan rekapitulasi absensi yang masih manual sehingga akan membutuhkan waktu yang cukup lama dalam prosesnya. Untuk  mengatasi hal tersebut,  perlu sebuah  metode baru dengan  merancang  dan  membangun  sebuah  sistem  informasi yang   dapat   memberikan   pengolahan   raport   serta   dapat menghasilkan  laporan yang sesuai. Sistem informasi pengolahan  raport  kurikulum  2013  dibangun  dengan  metode waterfall, sehingga dapat dihasilkan aplikasi yang memberikan informasi Raport yang diinginkan. Dengan adanya sistem informasi raport berbasis web, maka penyajian informasi akademik SDN Cawang 09 menjadi lebih cepat. Pengelolaan data-data menjadi lebih mudah serta dapat memberikan efisien waktu dan efektifitas dalam pembuatan suatu laporan.
SISTEM INFORMASI PELAPORAN REALISASI E-ORDER BERBASIS WEB PADA PEMERINTAH KOTA JAKARTA TIMUR
Authors: Andriati Windi
Published: October 2023

Sistem pelaporan realiasi e-order pada Pemerintah Kota Administrasi Jakarta Timur sudah terkomputerisasi tapi masih dijalankan melalui spreadsheet dan Bagian Keuangan masih mengalami kesulitan dalam pembuatan laporan setiap bulannya, dikarenakan sistem yang belum terintegrasi tersebut. Pembuatan laporan realiasasi sering mengalami keterlambatan dan membutuhkan waktu yang cukup lama dalam memonitoring UKPD yang belum melaporkan realisasi e-order setiap bulannya. Dalam pembuatan program ini, penulis menggunakan metode Waterfall, sehingga alur pengembangan sistemnya lebih mudah dipahami. Sistem Informasi Pelaporan Realisasi E-Order Berbasis Web Pada Pemerintah Kota Adm. Jakarta Timur adalah solusi terbaik yang dapat diberikan. Sistem ini berbasis web menggunakan bahasa pemrograman PHP dan MySql. Dengan adanya sistem informasi berbasis website ini, dapat lebih mudah dan efisien dalam pengolahan data realisasi e-order dan laporan dapat dibuat dengan dengan cepat dan efisien sebagai pertimbangan untuk pengambilan keputusan lebih baik. Kecamatan, Kelurahan dan Bagian Sekretariat Kota dibawah Walikota Jakarta Timur dapat dengan mudah memberikan laporan realisasi yang tepat waktu dan data yang diberikan dapat tersimpan dengan baik.
PERANCANGAN SISTEM INFORMASI MANAJEMEN INVENTORI PADA RETAIL PT. STARS INTERNASIONAL
Authors: Arribe Edo , Hafsari Rizka , Subekti Alfakih Anggi , Aragati Abdel Haris
Published: October 2023

Perkembangan teknologi yang pesat berperan penting bagi perusahaan guna mendongrak peforma dalam pengoptimalan kinerja operasional dan meningkatkan produktifitas perusahaan untuk bertahan dengan persaingan yang sangat ketat antar perusahaan lainnya. PT. Stars Internasional adalah perusahaan yang bergerak dibidang produksi sepatu serta sandal, proses pencatatan operasional dan transaksi bisnis yang masih menggunakan buku dan alat tulis, mengakibatkan kesalahan sering terjadi karena pencatatan, serta penempatan yang tidak tepat dan mengakibatkan kehilangan buku dan cara manual membuat proses pencarian data transaksi juga memakan waktu. Maka dari itu perlu merancang sistem informasi yang dapat melakukan fungsi pencatatan stok, laporan penjualan harian, operasional, dan pencarian data penjualan menjadi terotomatisasi. Sistem dirancang dengan UML (Unified Modeling Language) sebagai model sistem dan metode waterfall digunakan untuk pegembangan sistem. Dengan rancangan sistem informasi manajemen  yang dapat mengotomatisasi proses pencatatan, pengelolaan stok, pencatatan penjualan, dan pencatatan operasional ini diharapkan dapat mengatasi  hambatan yang dihadapi oleh perusahaan serta dapat meningkatkan efisiensi dan efektivitas operasional retail PT. Stars Internasional dengan harapan mampu menghadapi persaingan pasar yang semakin ketat.
Factors of Training Design and Training Facilities on Training Effectiveness at the Surakarta Vocational and Productivity Training Center
Authors: Cahyaningrum Anisya , Waskito Jati , Saputro Edy Purwo , Kussudyarsana
Published: October 2023

The study goals is to understand how facilities, research, and design influences training effectiveness at The Surakarta Vocational and Productivity Training Center. A sort of research as many as 96 respondents took part in this quantitative training at The Surakarta Vocational and Productivity Training Center. Primary data with measurement scales likert and data analysis using SPSS version 26 make up the research data sources. Dependent variables include the effectiveness of the training, whereas independent variables include the context, substance, and methodology of the training, as well as the competency of the trainers and the training facilities. According to the study's findings, (a) context, content, and material training are positively and significantly related to training effectiveness; (b) The method of training is The competency trainer is similarly positively and significantly connected to training effectiveness; (c) Training effectiveness is related to training effectiveness; (d)The training facilities are important to training efficacy and have a beneficial influence.
Optimization of Organizational Design as A Strategy to Improve Organizational Performance: Systematic Literature Review
Authors: Gunawan Bambang , Nurdiana Hera Nurul Fitri
Published: October 2023

This research is a literature study that reviews strategies for improving organizational performance through optimizing organizational design. The articles reviewed are articles that discuss organizational design and organizational performance. The review method used is a systematic literature review. The search for articles begins in 2016 – 2022. All articles sought are in English. Based on the search results obtained 988 articles. After the data inclusion and exclusion process was carried out, 18 potential articles were obtained for in-depth analysis. Based on the results of the synthesis carried out, it can be concluded that the role of organizational design is very visible in improving organizational performance. In addition, organizational design encourages the emergence of organizational innovation which ultimately encourages increased organizational performance.