bluuebunny/crossref_metadata_2025 huggingface dataset:
Femoral Anteversion Angle as a Predictor of Anterior Hip Labral Length in Patients With Femoroacetabular Impingement Syndrome
Authors: Zhang Hongguang , Gao Guanying , Liu Guangyuan , Zhang Siqi , Liu Rongge , Dong Hanmei , Xu Yan
Published: August 2024

Background:

The relationship between hip rotational abnormalities and hip labral size has not been fully investigated.

Purposes:

To (1) examine the correlation between rotational abnormalities of the hip and labral size, while also identifying other predictive values for hip labral size, and (2) explore whether femoral torsion will lead to increased labral size.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

A total of 180 patients (180 hips) with femoroacetabular impingement syndrome (FAIS) (mean age, 36.81 ± 10.17 years; 67 male, 113 female) who underwent hip arthroscopic surgery between January 2021 and May 2022 were included. The femoral version (FV), acetabular version, and combined version angles were measured on computed tomography, and the labral length and height at the 12-o’clock and 3-o’clock positions were measured on magnetic resonance imaging. The hips were categorized into 3 groups based on FV angle: small (SFV; <10°); moderate (MFV; ≥10° and ≤20°), and large (LFV; >20°), and group comparisons were performed. Linear correlation and regression analysis were employed.

Results:

Predictive factors for labral length were FV angle (β = 0.298; P = .02), sex (β = −0.302; P < .001), and age (β = −0.169; P = .016) at 3 o’clock and lateral center-edge angle (LCEA; β = −0.208; P = .005) and age (β = −0.186; P = .011) at 12 o’clock. FV angle was positively correlated with labral length at 3 o’clock ( r = 0.267; P < .001) and negatively correlated with age ( r = −0.222; P = .003) and female sex ( r = −0.202; P = .006). LCEA ( r = −0.227; P = .002) and age ( r = −0.205; P = .006) were negatively correlated with labral length at 12 o’clock. Labral length at 3 o’clock was significantly different between the LFV (n = 49 hips), MFV (n = 65 hips), and SFV (n = 66 hips) groups (9.85 ± 2.28, 8.89 ± 2.44, and 8.30 ± 2.05 mm, respectively; P = .027 for LFV vs MFV; P < .001 for LFV vs SFV).

Conclusion:

Patients with FAIS who exhibited a higher FV angle were at a greater likelihood of having a larger anterior labral length. Increased femoral anteversion and decreased LCEA, male sex, and younger age were significantly associated with longer hip labral length.
Comparison of Knotless Versus Knot-Tying Suture Anchors for Arthroscopic Repair of Hip Labral Tears
Authors: Celiksoz Aytek Huseyin , Bayram Berhan , Yozgatli Tahir Koray , Yilmaz Edip , Yassin Ali , Kayaalp Asim , Kocaoglu Baris
Published: August 2024

Background:

Both knotless and knot-tying anchors are commonly employed in the arthroscopic repair of hip labral tears.

Purpose:

To compare the midterm clinical results of arthroscopic hip labral repair using knot-tying versus knotless suture anchors.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Patients who underwent arthroscopic hip labral repair between January 2017 and January 2021 and who had at least 2 years of follow-up were included. The patients were divided into 2 groups based on the suture anchor type: a 2.9-mm knotless suture anchor (knotless group) or a 1.8-mm knot-tying suture anchor (knot-tying group). All patients underwent femoroplasty for cam lesions and acetabular rim trimming for pincer lesions. The modified Harris Hip Score (mHHS), Hip Outcome Score–Sport-Specific Subscale (HOS-SSS), Hip Outcome Score–Activities of Daily Living (HOS-ADL), 12-item International Hip Outcome Tool (iHOT-12), and visual analog scale (VAS) for pain were administered both preoperatively and postoperatively. The consistency of the outcome scores was assessed using the minimal clinically important difference and Patient Acceptable Symptom State. The statistical significance between groups was evaluated using the Mann-Whitney test and quantile-based analysis of variance.

Results:

A total of 413 patients were included: 256 patients in the knotless group (median age, 35 years [interquartile range, 31-38 years]; median follow-up, 34 months) and 157 patients in the knot-tying group (median age, 34 years [interquartile range, 30-38 years]; median follow-up, 25 months). There were no significant differences in postoperative mHHS, HOS-ADL, or iHOT-12 scores between the 2 groups. However, there were significant differences, favoring the knotless group over the knot-tying group, in postoperative HOS-SSS (87 ± 2 vs 86 ± 1, respectively) and VAS pain (1 vs 2, respectively) scores ( P < .0001 for both). Postoperative synovitis was found in significantly more patients in the knot-tying group than in the knotless group (17 vs 5, respectively; P = .01).

Conclusion:

In this study, patients who underwent arthroscopic hip labral repair with knotless suture anchors had slightly better postoperative HOS-SSS and VAS pain scores and a lower incidence of postoperative synovitis compared with patients who underwent repair with knot-tying suture anchors.
Heterozygous MEFV Mutation Leading to Renal Failure: A Case Study
Authors: El Gazzane Souhaila , Ichane Amine , Nahi Chaimae , Mouaddine Khadija , Chkirate Bouchra , Guennoun Aziza , Oulahiane Najat , Ait Ouamar Hassan , Rouas Lamiaa
Published: August 2024

Familial Mediterranean fever (FMF) is an autosomal recessive disorder, particularly common in the Mediterranean area. Mutations in the MEVF gene cause it. AA Amyloidosis is the most severe complication of FMF leading to chronic renal failure. We describe a rare pediatric case of a phenotype I familial Mediterranean fever with V726A heterozygous mutation. The diagnosis was made at chronic kidney disease. We discuss through this case the importance of the early diagnosis of FMF heterozygous children which is not usually evident in some phenotypes. It will surely avoid fatal complications, inappropriate therapeutic approaches and higher healthcare costs.
Effect on Ti/Mg isothermal oxidation of refinement microstructure and tribological behaviour of pure aluminium alloy by plasma spray coating
Authors: Rajendran Selvabharathi , Mohan Sekar
Published: August 2024

In this research paper have focusing in the plasma spray coating by Ti/Mg content isothermal oxidation processes at the temperature 900°C–1200°C at 5 h with using aluminium alloy. The temperature of plasma spray oxidation processes on pure aluminium alloy have converted at the α’ Ti phase and solid grain boundaries. Outer oxidation layer was formed in the 22 µm of grain size using plasma spray coating process and improve the mechanical properties and microstructure of the aluminium alloy. Ti/Mg oxidation layer was protecting the outer surface layer, while high temperature of oxygen reduction methods has implemented grain boundaries structure directly converted into the TiO2 and Al2O3 phases. The hardness value of Ti/Mg isothermal oxidation samples compared to the base materials was 28% increased. The average tensile testing of Ti/Mg oxidation samples was reached at the 556 MPa, 572 MPa and 628 MPa, 644 MPa, whereas Al lattice structure and α’delta phase has major contribution on face changes structure. Wear studies of were carried out at the 20 N load using environmental condition to increase the wear resistance of Ti/Mg isothermal oxidation sample. To identify the outer surface layer using atomic force microscopy with Ti/Mg oxidation method have implemented to reducing dimples, voids and cracks of the inner and outer surface layers. More interesting, Ti/Mg isothermal oxidation of tensile, bending and hardness testing have better strength and excellent wear resistance of all coated sample.
The impact of different doses of oral iron supplementation during pregnancy: a pilot randomized trial
Authors: Stanworth Simon J. , Churchill David , Sweity Samaher , Holmes Tom , Hudson Cara , Brown Rosemary , Lax Stephanie J. , Murray Joanne , Spiby Helen , Roy Noemi , Farmer Andrew , Gale Chris , Crayton Elise , Lorencatto Fabiana , Griffiths James , Mullings Joanne , Last Sara , Knight Marian
Published: August 2024

Oral iron is first-line medication for iron deficiency anemia in pregnancy. We conducted a pilot randomized trial to investigate the impact of different doses of oral iron supplementation started early in pregnancy on women without anemia for 4 main outcomes: recruitment and protocol compliance, adherence, maintenance of maternal hemoglobin, and side effects. At antenatal clinic visits, participants were allocated to 1 of 3 trial arms in a 1:1:1 ratio: 200 mg ferrous sulfate daily, alternate days, or 3 times per week. The participants were followed to delivery. Baseline characteristics of 300 recruited participants were well matched between trial arms. The mean proportion of tablets taken as expected per participant was 82.5% overall (72.3%, 89.6%, and 84.5% for the daily, alternate days, and 3 times a week arm, respectively). There was a lower overall adherence rate in the daily arm (47%) than in the alternate days (62%) and the 3 times per week (61%) arms. A reduction in hemoglobin between randomization and 28 weeks’ gestation seemed smaller for the daily arm. A range of side effects were commonly reported at baseline before starting interventions and at later antenatal visits. Many side effects of iron overlapped with normal pregnancy symptoms. A daily iron dosing schedule might give the best opportunity for delivering an adequate iron load during pregnancy in women without anemia. Further randomized trials powered on clinical outcomes are needed to establish the clinical effectiveness of oral iron supplementation to prevent iron deficiency anemia. This study was registered (#ISRCTN12911644).
Pathology and pathobiology of pulmonary hypertension: current insights and future directions
Authors: Guignabert Christophe , Aman Jurjan , Bonnet Sébastien , Dorfmüller Peter , Olschewski Andrea J. , Pullamsetti Soni , Rabinovitch Marlene , Schermuly Ralph T. , Humbert Marc , Stenmark Kurt R.
Published: August 2024

In recent years, major advances have been made in the understanding of the cellular and molecular mechanisms driving pulmonary vascular remodelling in various forms of pulmonary hypertension, including pulmonary arterial hypertension, pulmonary hypertension associated with left heart disease, pulmonary hypertension associated with chronic lung disease and hypoxia, and chronic thromboembolic pulmonary hypertension. However, the survival rates for these different forms of pulmonary hypertension remain unsatisfactory, underscoring the crucial need to more effectively translate innovative scientific knowledge into healthcare interventions. In these proceedings of the 7th World Symposium on Pulmonary Hypertension, we delve into recent developments in the field of pathology and pathophysiology, prioritising them while questioning their relevance to different subsets of pulmonary hypertension. In addition, we explore how the latest omics and other technological advances can help us better and more rapidly understand the myriad basic mechanisms contributing to the initiation and progression of pulmonary vascular remodelling. Finally, we discuss strategies aimed at improving patient care, optimising drug development, and providing essential support to advance research in this field.
Transplantation, bridging, and support technologies in pulmonary hypertension
Authors: Savale Laurent , Benazzo Alberto , Corris Paul , Keshavjee Shaf , Levine Deborah Jo , Mercier Olaf , Davis R. Duane , Granton John T.
Published: August 2024

Despite the progress made in medical therapies for treating pulmonary hypertension (PH), a subset of patients remain susceptible to developing a maladaptive right ventricular phenotype. The effective management of end-stage PH presents substantial challenges, necessitating a multidisciplinary approach and early identification of patients prone to acute decompensation. Identifying potential transplant candidates and assessing the feasibility of such a procedure are pivotal tasks that should be undertaken early in the treatment algorithm. Inclusion on the transplant list is contingent upon a comprehensive risk assessment, also considering the specific type of PH and various factors affecting waiting times, all of which should inform the decision-making process. While bilateral lung transplantation is the preferred option, it demands expert intra- and post-operative management to mitigate the heightened risks of pulmonary oedema and primary graft dysfunction in PH patients. Despite the availability of risk assessment tools, the occurrence of acute PH decompensation episodes can be unpredictable, potentially leading to refractory right ventricular failure even with optimal medical intervention, necessitating the use of rescue therapies. Advancements in right ventricular assist techniques and adjustments to graft allocation protocols for the most critically ill patients have significantly enhanced the survival in intensive care, affording the opportunity to endure while awaiting an urgent transplant. Given the breadth of therapeutic options available, specialised centres capable of delivering comprehensive care have become indispensable for optimising patient outcomes. These centres are instrumental in providing holistic support and management tailored to the complex needs of PH patients, ultimately enhancing their chances of a successful transplant and improved long-term prognosis.
Chronic thromboembolic pulmonary disease
Authors: Kim Nick H. , D'Armini Andrea M. , Delcroix Marion , Jaïs Xavier , Jevnikar Mitja , Madani Michael M. , Matsubara Hiromi , Palazzini Massimiliano , Wiedenroth Christoph B. , Simonneau Gérald , Jenkins David P.
Published: August 2024

Chronic thromboembolic pulmonary hypertension is a complication of pulmonary embolism and a treatable cause of pulmonary hypertension. The pathology is a unique combination of mechanical obstruction due to failure of clot resolution, and a variable degree of microvascular disease, that both contribute to pulmonary vascular resistance. Accordingly, multiple treatments have been developed to target the disease components. However, accurate diagnosis is often delayed. Evaluation includes high-quality imaging modalities, necessary for disease confirmation and for appropriate treatment planning. All patients with chronic thromboembolic pulmonary disease, and especially those with pulmonary hypertension, should be referred to expert centres for multidisciplinary team decision on treatment. The first decision remains assessment of operability, and the best improvement in symptoms and survival is achieved by the mechanical therapies, pulmonary endarterectomy and balloon pulmonary angioplasty. With the advances in multimodal therapies, excellent outcomes can be achieved with 3-year survival of >90%.
Risk stratification and treatment goals in pulmonary arterial hypertension
Authors: Dardi Fabio , Boucly Athénaïs , Benza Raymond , Frantz Robert , Mercurio Valentina , Olschewski Horst , Rådegran Göran , Rubin Lewis J. , Hoeper Marius M.
Published: August 2024

Risk stratification has gained an increasing role in predicting outcomes and guiding the treatment of patients with pulmonary arterial hypertension (PAH). The most predictive prognostic factors are three noninvasive parameters (World Health Organization functional class, 6-min walk distance and natriuretic peptides) that are included in all currently validated risk stratification tools. However, suffering from limitations mainly related to reduced specificity of PAH severity, these variables may not always be adequate in isolation for guiding individualised treatment decisions. Moreover, with effective combination treatment regimens and emerging PAH therapies, markers associated with pulmonary vascular remodelling are expected to become of increasing relevance in guiding the treatment of patients with PAH. While reaching a low mortality risk, assessed with a validated risk tool, remains an important treatment goal, preliminary data suggest that invasive haemodynamics and cardiac imaging may add incremental value in guiding treatment decisions.
Pulmonary hypertension associated with left heart disease
Authors: Maron Bradley A. , Bortman Guillermo , De Marco Teresa , Huston Jessica H. , Lang Irene M. , Rosenkranz Stephan H. , Vachiéry Jean-Luc , Tedford Ryan J.
Published: August 2024

Left heart disease (LHD) is the most common cause of pulmonary hypertension (PH), which may be classified further as isolated post-capillary (ipcPH) or combined post- and pre-capillary PH (cpcPH). The 7th World Symposium on Pulmonary Hypertension PH-LHD task force reviewed newly reported randomised clinical trials and contemplated novel opportunities for improving outcome. Results from major randomised clinical trials reinforced prior recommendations against the use of pulmonary arterial hypertension therapy in PH-LHD outside of clinical trials, and suggested possible harm. Greater focus on phenotyping was viewed as one general strategy by which to ultimately improve clinical outcomes. This is potentially achievable by individualising ipcPHversuscpcPH diagnosis for patients with pulmonary arterial wedge pressure within a diagnostic grey zone (12–18 mmHg), and through a newly developed PH-LHD staging system. In this model, PH accompanies LHD across four stages (A=at risk, B=structural heart disease, C=symptomatic heart disease, D=advanced), with each stage characterised by progression in clinical characteristics, haemodynamics and potential therapeutic strategies. Along these lines, the task force proposed disaggregating PH-LHD to emphasise specific subtypes for which PH prevalence, pathophysiology and treatment are unique. This includes re-interpreting mitral and aortic valve stenosis through a contemporary lens, and focusing on PH within the hypertrophic cardiomyopathy and amyloid cardiomyopathy clinical spectra. Furthermore, appreciating LHD in the profile of PH patients with chronic lung disease and chronic thromboembolic pulmonary disease is essential. However, engaging LHD patients in clinical research more broadly is likely to require novel methodologies such as pragmatic trials and may benefit from next-generation analytics to interpret results.
Embracing the challenges of neonatal and paediatric pulmonary hypertension
Authors: Ivy Dunbar , Rosenzweig Erika B. , Abman Steven H. , Beghetti Maurice , Bonnet Damien , Douwes Johannes Menno , Manes Alessandra , Berger Rolf M.F.
Published: August 2024

Paediatric pulmonary arterial hypertension (PAH) shares common features with adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for caring for infants and children with PAH, as presented by the paediatric task force of the 7th World Symposium on Pulmonary Hypertension. We provide updates on diagnosing, classifying, risk-stratifying and treating paediatric pulmonary hypertension (PH) and identify critical knowledge gaps. An updated risk stratification tool and treatment algorithm is provided, now also including strategies for patients with associated cardiopulmonary conditions. Treatment of paediatric PH continues to be hindered by the lack of randomised controlled clinical trials. The challenging management of children failing targeted PAH therapy is discussed, including balloon atrial septostomy, lung transplantation and pulmonary-to-systemic shunt (Potts). A novel strategy using a multimodal approach for the management of PAH associated with congenital heart diseases with borderline pulmonary vascular resistance is included. Advances in diagnosing neonatal PH, especially signs and interpretation of PH by echocardiography, are highlighted. A team approach to the rapidly changing physiology of neonatal PH is emphasised. Challenges in drug approval are discussed, particularly the challenges of designing accurate paediatric clinical trials with age-appropriate end-points and adequate enrolment.
IAA is more effective than EDTA in enhancing phytoremediation potential for cadmium and copper contaminated soils
Authors: Shah Naila , Irshad Muhammad , Murad Waheed , Hamayun Muhammad , Qadir Muhammad , Hussain Anwar , Begum Hussan Ara , Alrefaei Abdulwaahed Fahad , Almutairi Mikhlid H. , Ahmad Ayaz , Ali Sajid
Published: August 2024

Enhanced phytoremediation offers a rapid and eco-friendly approach for cleaning agricultural soil contaminated with copper and cadmium which pose a direct threat to food scarcity and security. The current study aimed to compare the effectiveness of the two commonly used additives, IAA and EDTA, for the remediation of copper (Cu) and cadmium (Cd) contaminated soils using sunflower and maize. The plants were cultivated in pots under controlled conditions with four sets of treatments: control (0), Cu50/Cd50, Cu50/Cd50 + EDTA, and Cu50/Cd50 + IAA. The results showed that Cu50/Cd50 mg/kg drastically compromised the phytoremediation potential of both plants, as evident by reduced shoot and root length, and lower biomass. However, the augmentation of Cu50/Cd50 with EDTA or IAA improved the tested parameters. In sunflower, EDTA enhanced the accumulation of Cu and Cd by 58% and 21%, respectively, and improved plant biomass by 41%, compared to control treatment. However, IAA exhibited higher accumulation of Cu and Cd by 64% and 25%, respectively, and enhanced plant biomass by 43%. In case of maize, IAA was superior to EDTA which enhanced the accumulation of Cu and Cd by 87% and 32% respectively, and increased the plant biomass by 57%, compared to control treatment. Our findings demonstrate that foliar IAA is more effective than EDTA in enhancing the phytoremediation potential of sunflower and maize for Cu and Cd.
The causal relationship model of factors influencing COVID-19 preventive behaviors during the post-pandemic era and implications for health prevention strategies: a case of Bangkok City, Thailand
Authors: Janmaimool Piyapong , Chontanawat Jaruwan , Nunsunanon Siriphan , Chudech Surapong
Published: August 2024

Background

Though, many countries are currently in the COVID post-pandemic era, people’s health protective behaviours are still essential to protect their health and well-being. This study aims to evaluate people’s understanding and perceptions of COVID-19 risk characteristics (i.e. threat occurrence, threat severity, perceived susceptibility and exposure), the health risk perception towards COVID-19, and health protective behaviours. The study also aims to estimate the associations among these factors by the analysis of structural equation modelling (SEM).

Methods

From 15 October to 9 November 2022, questionnaire surveys were administrated to 521 people living in Bangkok of Thailand by using the convenience sampling technique. The analyses were carried out in three phases including descriptive statistical analyses, a measurement model assessment using a confirmatory factor analysis (CFA), and structural equation modelling (SEM) analysis.

Results

The results of descriptive analyses demonstrated that the majority of respondents, 39.9%, had the age between 20 and 30 years old, and 61.4% of them were female. Approximately 52.1% of them had a bachelor’s degree. Upon analysing individuals’ understanding and perceptions of all risk characteristics, individuals’ understanding of COVID-19 severity did not statistically affect health risk perception towards COVID-19, whereas perceived exposure had the strongest effect and in turn influenced health protective behaviours. Perceived susceptibility and understanding of the threat occurrence also significantly affected health risk perception, and indirectly affected health protective behaviours.

Conclusions

This study implies that though the potential health impact of COVID-19 is perceived as less severe, people can still construct a perception of its risk particularly based on their perceived exposure and susceptibility. Thus, communicating people about exposure conditions and susceptibility can greatly contribute to people’ construction of risk perception towards COVID-19 which subsequently leads to the decision to perform health protective behaviours.
Understanding the mental health and intention to leave of the public health workforce in Canada during the COVID-19 pandemic: A cross-sectional study
Authors: Belita Emily , Neil-Sztramko Sarah E. , De Rubeis Vanessa , Boamah Sheila , Cabaj Jason , Jack Susan M. , Neudorf Cory , Zogo Clemence Ongolo , Seale Carolyn , Watson-Creed Gaynor , Dobbins Maureen
Published: August 2024

Background

There is limited evidence about the mental health and intention to leave of the public health workforce in Canada during the COVID-19 pandemic. The objectives of this study were to determine the prevalence of burnout, symptoms of anxiety and depression, and intention to leave among the Canadian public health workforce, and associations with individual and workplace factors.

Methods

A cross-sectional study was conducted using data collected by a Canada-wide survey from November 2022 to January 2023, where participants reported sociodemographic and workplace factors. Mental health outcomes were measured using validated tools including the Oldenburg Burnout Inventory, the 7-item Generalized Anxiety Disorder scale, and the 2-item Patient Health Questionnaire to measure symptoms of depression. Participants were asked to report if they intended to leave their position in public health. Logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) for the associations between explanatory variables such as sociodemographic, workplace factors, and outcomes of mental health, and intention to leave public health.

Results

Among the 671 participants, the prevalence of burnout, and symptoms of depression and anxiety in the two weeks prior were 64%, 26%, and 22% respectively. 33% of participants reported they were intending to leave their public health position in the coming year. Across all outcomes, sociodemographic factors were largely not associated with mental health and intention to leave. However, an exception to this was that those with 16–20 years of work experience had higher odds of burnout (aOR = 2.16; 95% CI = 1.12–4.18) compared to those with ≤ 5 years of work experience. Many workplace factors were associated with mental health outcomes and intention to leave public health. Those who felt bullied, threatened, or harassed because of work had increased odds of depressive symptoms (aOR = 1.85; 95% CI = 1.28–2.68), burnout (aOR = 1.61; 95% CI = 1.16–2.23), and intention to leave (aOR = 1.64; 95% CI = 1.13–2.37).

Conclusions

During the COVID-19 pandemic, some of the public health workforce experienced negative impacts on their mental health. 33% of the sample indicated an intention to leave their role, which has the potential to exacerbate pre-existing challenges in workforce retention. Study findings create an impetus for policy and practice changes to mitigate risks to mental health and attrition to create safe and healthy working environments for public health workers during public health crises.
Credibility of Pont’s index in Egyptian population
Authors: Zahw Esraa Khaled , Albelasy Nehal Fouad , Fouda Ahmed Maher
Published: August 2024

Background

Many indices have been suggested to help orthodontists in predicting the ideal dental arch width. One of these was Pont’s index which was established by Pont. He suggested equations to predict the ideal maxillary dental arch width (interpremolar and intermolar) from the combined mesiodistal width of the maxillary incisors. This study aimed to test the applicability of Pont’s index as an orthodontic diagnostic tool in Egyptian population and to compare the results with those obtained from studies of different ethnic subjects.

Methods

This study was performed using dental casts of 184 Egyptian individuals (82 males and 102 females; age range, 19–24 years). The casts were divided into 46 casts with normal occlusion, 46 casts with class I, 46 casts with class II and 46 casts with class III malocclusion, according to Angle’s classification. Alginate impressions were taken for all patients and poured immediately using dental plaster. The real models were transformed into digital models using three-dimensional laser scanner to allow digital model analysis. Predicted arch widths were calculated using Pont’s equations. The predicted values were compared to the measured values.

Results

Intra class correlation coefficient (ICC) (absolute agreement) between measured and predicted arch widths was determined. Poor absolute agreement was found between measured arch width values and the corresponding values calculated according to Pont’s index.

Conclusion

According to the results of this study, Pont’s index is not a reliable method for predicting the ideal dental arch widths in Egyptian populations.
Two-year clinical performance of indirect resin composite restorations in endodontically treated teeth with different cavity preparation designs: a randomized clinical trial
Authors: Fouda Hoda , Hassanein Olfat Elsayed , Saber Shehabeldin , Haridy Mohamed Fouad , Baz Maha El , Ahmed Hend Sayed , Abuelezz Ahmed
Published: August 2024

Trial design

This is a randomized, controlled, superiority, double-blinded, parallel-group, two-arms trial with an allocation ratio of 1:1. This study aimed to assess whether the cavity design could affect the clinical performance of the CAD/CAM generated indirect resin composite restoration in endodontically treated teeth (ETT) evaluated using the Modified USPHS criteria after a two-year follow up.

Methods

A total of 30 participants who underwent endodontic treatment for MOD cavities in permanent molars were divided randomly into two parallel groups (n = 30 restorations) according to the performed cavity design to group 1 in which there was no cuspal reduction (inlay) and group 2 in which cuspal reduction was performed (overlay). All pulp chambers were filled with bulk fill flowable composite, and the cavities were prepared following the criteria of the cavities for indirect restorations and restored using nano-hybrid composite resin blocks (Brilliant, Coltene, Switzerland). The restorations were evaluated using the modified USPHS criteria at baseline, six months, one-year and two years follow-up visits. For qualitative data, frequencies (n) and percentages (%) were used to display the data, while mean and standard deviation (SD) were used for quantitative data. The normality of the data was evaluated using the Shapiro-Wilk and Kolmogorov-Smirnov tests. For every test, P ≤ 0.05 was used as the significance threshold.

Results

Twenty-six individuals completed the follow-up period after receiving the assigned intervention.The inter-group comparison showed that, at the 6- months and 12- months observation points, the overlay design had significantly better marginal adaptation, less incidence of discoloration or tooth/restoration fracture, and similar marginal integrity and caries incidence to the inlay design. After 24- months, the overlay design still had better marginal adaptation, less incidence of discoloration or tooth/restoration fracture and less caries incidence in comparison to the inlay design, while there was no difference in the marginal integrity between either design.

Conclusions and clinical relevance

Cuspal reduction in endodontically treated teeth showed better clinical performance than the cusp preservation thus, the former is more reliable.
Implantable antennas for biomedical applications: a systematic review
Authors: Mohan Archana , Kumar Niraj
Published: August 2024

This review presents an in-depth examination of implantable antennas for various biomedical purposes. The development of implantable antennas, including their designs, materials, and operating principles, are introduced at the beginning of the discussion. An overview of the many kinds of implantable antennas utilized in implantable medical devices (IMDs) are presented in this study. The article then discusses the important factors to consider when developing implantable antennas for biomedical purposes, including implant placement, frequency range, and power needs. This investigation additionally examines the challenges and limitations encountered with implantable antennas, including the limited space available within the human body, the requirement for biocompatible materials, the impact of surrounding tissue on antenna performance, tissue attenuation, and signal interference. This review also emphasizes the most recent advances in implanted antenna technology, such as wireless power transmission, multiband operation, and miniaturization. Furthermore, it offers illustrations of several biomedical uses for implantable antennas, including pacemaker, capsule endoscopy, intracranial pressure monitoring, retinal prostheses, and bone implants. This paper concludes with a discussion of the future of implantable antennas and their possible use in bioelectronic medicine and novel medical implants. Overall, this survey offers a thorough analysis of implantable antennas in biomedical applications, emphasizing their importance in the development of implantable medical technology.
Association between high-density lipoprotein and functional outcome of ischemic stroke patients in a Taiwanese population
Authors: Lin Ting-Chun , Huang Chun-Yao , Li Yu-Ling , Chiou Hung-Yi , Hu Chaur-Jong , Jeng Jiann-Shing , Tang Sung-Chun , Chan Lung , Lien Li-Ming , Lin Huey-Juan , Lin Chu-Chien , Hsieh Yi-Chen
Published: August 2024

Despite recent findings indicating a paradoxical association between high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular disease (CVD) mortality, the impact of HDL-C on subsequent outcomes after ischemic stroke remains unclear. The study aims to investigate the relationships between HDL-C levels and post-stroke functional outcomes while examining the potential modifying influence of HDL-C-related single nucleotide polymorphisms identified through genome-wide association studies. This cohort study included 1,310 patients diagnosed with acute ischemic stroke (AIS), all of whom had their admission serum lipid profile and genotyping information. Participants were categorized into four groups based on gender and HDL-C level. Prognostic outcomes were assessed using a modified Rankin Scale (mRS) at 1, 3, and 12 months post-admission. Multivariate logistic regression and restricted cubic spline regression analysis were used to assess the associations between HDL-C levels and outcomes. The mean age of patients was 61.17 ± 12.08 years, and 69.31% were men. After adjusting confounders, patients with the highest HDL-C level group had a significantly higher risk of poor functional outcomes at 1, 3, and 12 months following stroke compared to the reference group. Restricted cubic splines depicted a nonlinear association between HDL-C levels and poor prognosis in both men and women. The ABCA1 gene rs2575876 AA genotype combined with abnormal HDL-C levels exhibited a significantly heightened risk of post-stroke adverse outcomes at 1 and 3 months compared to patients with normal HDL-C levels and GG + GA genotype. These findings suggest that the combined effects of ABCA1 genetic variants with either low or high HDL-C levels could further heighten this risk.
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
Authors: Chen Qiang , Aguirre Luis , Liang Guoming , Zhao Huanhuan , Dong Tao , Borrego Felix , de Rojas Itziar , Hu Qichan , Reyes Christopher , Su Ling-Yan , Zhang Bao , Lechleiter James D. , Göring Harald H. H. , De Jager Philip L. , Kleinman Joel E. , Hyde Thomas M. , Li Pan P. , Ruiz Agustín , Weinberger Daniel R. , Seshadri Sudha , Ma Liang
Published: August 2024

Background

The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regulatory mechanisms at this locus remain incompletely characterized.

Methods

To identify novel AD-linked functional elements within the APOE locus, we integrated SNP variants with multi-omics data from human postmortem brains including 2,179 RNA-seq samples from 3 brain regions and two ancestries (European and African), 667 DNA methylation samples, and ChIP-seq samples. Additionally, we plotted the expression trajectory of APOE transcripts in human brains during development.

Results

We identified an AD-linked APOE transcript (jxn1.2.2) particularly observed in the dorsolateral prefrontal cortex (DLPFC). The APOE jxn1.2.2 transcript is associated with brain neuropathological features, cognitive impairment, and the presence of the APOE4 allele in DLPFC. We prioritized two independent functional SNPs (rs157580 and rs439401) significantly associated with jxn1.2.2 transcript abundance and DNA methylation levels. These SNPs are located within active chromatin regions and affect brain-related transcription factor-binding affinities. The two SNPs shared effects on the jxn1.2.2 transcript between European and African ethnic groups.

Conclusion

The novel APOE functional elements provide potential therapeutic targets with mechanistic insight into the disease etiology.
Cerebral blood flow and cognition after 3 months tadalafil treatment in small vessel disease (ETLAS-2): study protocol for a randomized controlled trial
Authors: Ölmestig Joakim , Mortensen Kristian Nygaard , Fagerlund Birgitte , Naveed Nadia , Nordling Mette Maria , Christensen Hanne , Iversen Helle Klingenberg , Poulsen Mai Bang , Siebner Hartwig Roman , Kruuse Christina
Published: August 2024

Background

Targeted treatment is highly warranted for cerebral small vessel disease, a causal factor of one in four strokes and a major contributor to vascular dementia. Patients with cerebral small vessel disease have impaired cerebral blood flow and vessel reactivity. Tadalafil is a specific phosphodiesterase 5 inhibitor shown to improve vascular reactivity in the brain.

Methods

The ETLAS-2 trial is a phase 2 double-blind, randomized placebo-controlled, parallel trial with the feasibility of tadalafil as the primary outcome. The trial aims to include 100 patients with small vessel occlusion stroke or transitory ischemic attacks and signs of cerebral small vessel disease more than 6 months before administration of study medication. Patients are treated for 3 months with tadalafil 20 mg or placebo daily and undergo magnetic resonance imaging (MRI) to evaluate changes in small vessel disease according to the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE) criteria as well as cerebral blood flow, cerebrovascular reactivity, and neurovascular coupling in a functional MRI sub-study. The investigation includes comprehensive cognitive testing using paper–pencil tests and Cambridge Neuropsychological Test Automated Battery (CANTAB) tests in a cognitive sub-study.

Discussion

The ETLAS-2 trial tests the feasibility of long-term treatment with tadalafil and explores vascular and cognitive effects in cerebral small vessel disease in trial sub-studies. The study aims to propose a new treatment target and improve the understanding of small vessel disease. Currently, 64 patients have been included and the trial is estimated to be completed in the year 2024.

Trial registration

Clinicaltrials.gov, NCT05173896. Registered on 30 December 2021.
The child dental care reform in Israel – service uptake from 2011 to 2022
Authors: Domb Herman Hagit , Dadosh Hazav , Dekel Dan , Yellon David , Zusman Shlomo Paul , Natapov Lena
Published: August 2024

Background

The 2010 Child Dental Care Reform of the National Health Insurance Law marked a turning point in the Israeli oral healthcare system by establishing Universal Health Coverage of dental care for children. Initially, the reform included children up to age 8 and gradually expanded to age 18 in 2019. The basket of services includes preventive and restorative treatments provided by the four Health Maintenance Organizations (HMO). The aim of this study was to examine the uptake of child dental services during the first decade of the reform.

Methods

A retrospective analysis was conducted to determine the treatment uptake, type and amount of the services delivered based on annual service utilization reports submitted by the HMOs to the Ministry of Health in the years 2011–2022.

Results

The number of insured children increased from 1,546,857 in 2011 to 3,178,238 in 2022. The uptake of dental services gradually increased during the study period with a slight decrease in 2020. The percentage of children who used the services gradually increased from 8 to 33%, with the incremental inclusion of additional age groups. From 2012 onwards the most common treatments provided were preventive, however the single most common treatment was dental restoration. In 2022 35% of the population of Israel was under the age of 18. Out of these, about a third received dental treatment via the HMOs. This is a significant achievement, since before the reform all treatments were paid out-of-pocket. After a short period of increasing uptake, a stable service utilization pattern was evident that can indicate better public awareness and service acceptance.

Conclusion

Although this is a reasonable uptake, additional efforts are required to increase the number of children receiving dental care within the public insurance. Such an effort can be part of a multi-disciplinary approach, in which pediatricians and public health nurses can play a vital role in dental caries prevention, enhancement of awareness and service utilization.
Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice
Authors: Sessler Thomas M. , Beier Justus P. , Villwock Sophia , Jonigk Danny , Dahl Edgar , Ruhl Tim
Published: August 2024

Background

Adipocytokines play a pivotal role in maintaining adipose tissue homeostasis by regulating cellular metabolism, proliferation, differentiation, and secretory activity. These soluble factors are relevant components for healthy adipose tissue, while their deficiency is closely associated with the development of obesity and related metabolic diseases, e.g., chronic inflammation. In human adipose tissue, inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is expressed in proportion to the development of adipose tissue, i.e., the individual’s BMI. Thus, ITIH5 has been proposed to be an inert marker of human obesity. However, when applied to adipose stem cells in vitro, recombinant (r)ITIH5 protein inhibited proliferation and adipogenesis, suggesting that ITIH5 negatively affects the development of fat mass. We now tested the role of ITIH5 in vivo and compared ITIH5+/+ wildtype with ITIH5−/− knockout mice.

Results

Genetic deletion of ITIH5 significantly increased adipose tissue mass relative to animal bodyweight (p < 0.05). Next, we characterized adipose stem cells (ASCs) from both genotypes in vitro. ITIH5−/− cells exhibited increased proliferation and adipogenic differentiation (p < 0.001), which could explain the increase in adipose tissue in vivo. Furthermore, ASCs from ITIH5−/− animals were more responsive to stimulation with inflammatory mediators, i.e., these cells released greater amounts of IL-6 and MCP-1 (p < 0.001). Importantly, the application of the rITIH5 protein reversed the observed knockout effects in ASCs.

Conclusions

Our data suggest that ITIH5 potently regulates adipose tissue development and homeostasis by modulating ASC biology in mice. In addition, the effect of the rITIH5 protein underscores its potential as a therapeutic agent to correct the adipose tissue dysregulation often associated with obesity and metabolic disorders.
Public mental health services in Southern China and related health outcomes among individuals living with severe mental illness
Authors: Qiu Dan , Li Yilu , Xiao Shuiyuan , Zhou Liang , Liu Lianzhong , Liu Huiming , Gao Feihong , Wu Qiuyan , An Yanni , Tang Zixuan
Published: August 2024

Background

Although national policies in China are comprehensive and instructive, a wide disparity exists between different cities. The current status of public mental health services by region in China remains unclear. This study aimed to investigate policies related to public mental health services, the contact coverage of public mental health services and outcomes of service users.

Methods

A cross-sectional study was carried out in Southern China, between April 2021 and March 2022.  Considering the geographical location, socioeconomic development levels, and prevalence of severe mental illness, four cities including Wuhan, Changsha, Guangzhou, and Shenzhen were selected. Relevant service providers were asked to report data on mental health policies and facility-related information, including mental health resources, registration rates of patients, management rates of patients, and medication rates of patients. Eligible patients were invited to report service user-related data, including contact coverage of public mental health services and their outcomes. SPSS 26.0 was used for data analysis.

Results

The four cities in Southern China have made different efforts to develop public mental health services, primarily focusing on socio-economically disadvantaged individuals. Community health centers in Guangzhou and Shenzhen reported having more professional human resources on mental health and higher mental health budgets for patients. The contact coverage rates of most public mental services were higher than 80%. Patients in Changsha (B = 0.3; 95%CI: 0.1–0.5), Guangzhou (B = 0.2; 95%CI: 0.1–0.3), and Shenzhen (B = 0.3; 95%CI: 0.1–0.4) who received social medical assistance services reported higher levels of medication adherence. Patients in Wuhan (B = -6.5; 95%CI: -12.9--0.1), Guangzhou (B = -2.8; 95%CI: -5.5--0.1), and Shenzhen who received community-based rehabilitation services reported lower levels of disability (B = -2.6; 95%CI: -4.6--0.5).

Conclusions

There have been advances in public mental health services in the four Southern cities. The contact coverage rates of most public mental health services were higher than 80%. Patients’ utilization of public mental services was associated with better health outcomes. To improve the quality of public mental health services, the government should try to engage service users, their family members, and supporters in the design, delivery, operationalization, and evaluation of these public mental health services in the future.