bluuebunny/crossref_metadata_2025 huggingface dataset:
Return to Work and Sport After Distal Femoral Osteotomy: A Systematic Review
Authors: Bassi Jaspal S. , Chan Justin P. , Johnston Tyler , Wang Dean
Published: September 2021

Context:

Distal femoral osteotomy (DFO) is a joint preservation procedure that corrects genu valgum deformities and patellofemoral maltracking, thereby restoring kinematics and unloading contact pressures in the lateral tibiofemoral and patellofemoral compartments.

Objective:

To evaluate the rates of return to work (RTW) and return to sport (RTS) after DFO for valgus malalignment and lateral compartment osteoarthritis through a systematic review of the literature.

Data Sources:

A systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted on the PubMed, Cochrane, and Embase databases.

Study Selection:

The search terms femoral osteotomy AND ( sports OR work) were used. Studies in which patients underwent concomitant total knee arthroplasty were excluded.

Study Design:

Systematic review.

Level of Evidence:

Level 4 (systematic review of level 4 studies).

Data Extraction:

Data included the number of patients, age, gender, laterality of operation, time to follow-up, rate of RTW and RTS, time to RTS, activity level on return, and activity level scores (Tegner, Marx, Lysholm, and the International Knee Documentation Committee). Risk of bias was assessed using the Methodological Index for Non-Randomized Studies (MINORS) criteria.

Results:

Seven articles with 194 patients were included. The average age ranged from 19 to 49 years with a mean postoperative follow-up range of 36 to 90 months. RTW data were available for 125 patients, of whom 42.1% to 91.3% returned by final follow-up. Data on RTS were available for 149 patients, of whom 70% to 100% returned at a range of 8.3 to 16.9 months postoperatively, and 41.6% to 100% returned to the same or greater level of sports activity. The Tegner and Marx activity level scores ranged from 3 to 4 and from 5 to 11, respectively, at final follow-up.

Conclusion:

Patients treated with DFO reported high rates of RTW and RTS, with most patients being able to return to recreational sport after surgery.
Evidence That In-Service Professional Learning for Educational Leaders Matters
Authors: Meyers Coby V. , Wronowski Meredith L. , LaMonica Laura
Published: September 2021

Educator leadership requires continuous development, including extended professional learning opportunities for principals in the field. This is also true for district leaders who likely have even fewer robust opportunities to grow professionally. We conducted a comparative interrupted time series of publicly available student achievement data from New Mexico to analyze the impact of a university-based organization that partners with district leaders to provide intensive professional learning opportunities for district leaders and school principals. We found positive impacts on student achievement in math and for English learners in English language arts. Implications for educator preparation and in-service programs are considered.
Persuading the Implicit Mind: Changing Negative Implicit Evaluations With an 8-Minute Podcast
Authors: Kurdi Benedek , Mann Thomas C. , Ferguson Melissa J.
Published: September 2021

Implicit evaluations can be malleable via reinterpretation of previously encountered evidence. Here, we report three studies ( N = 1,007) investigating the robustness of this updating modality using ecologically realistic materials. Participants were first introduced to a target who killed an endangered black rhino in Namibia. They then listened to a real podcast providing counterattitudinal information on the benefits of trophy hunting. The podcast resulted in considerable revisions of initially negative implicit evaluations toward positivity, consistently across implicit measures (affect misattribution procedures vs. implicit association test), samples (American students vs. nonstudents from various countries), study settings (lab vs. online), and the presence versus absence of a memory retrieval manipulation prompting reflection on participants’ views on trophy hunting. Taken together, these findings suggest that reinterpretation can shift implicit evaluations of even highly negative targets, including under conditions of external validity.
Extroversion and Conscientiousness Predict Deteriorating Job Outcomes During the COVID-19 Transition to Enforced Remote Work
Authors: Evans Anthony M. , Meyers M. Christina , De Calseyde Philippe P. F. M. Van , Stavrova Olga
Published: September 2021

At the beginning of the COVID-19 pandemic, organizations around the world rapidly transitioned to enforced remote work. We examined the relationship between personality and within-person changes in five job outcomes (self-reported performance, engagement, job satisfaction, burnout, and turnover intentions) during this transition. We conducted a four-wave longitudinal study, from May to August 2020, of employees working from home due to COVID-19, N = 974. On average, self-reported performance decreased over the course of the study, whereas the other outcomes remained stable. There was also significant between-person variability in job outcomes. Extroversion and conscientiousness, two traits traditionally associated with desirable outcomes, were associated with deteriorating outcomes over time. Extroverted employees and conscientious employees became less productive, less engaged, and less satisfied with their jobs; and extroverted employees reported increasing burnout. These results add to our understanding of how personality predicts within-person changes in performance, well-being, and turnover intentions during the pandemic.
Vicarious Justifications for Prejudice in the Application of Democratic Values
Authors: White Mark H. , Crandall Christian S. , Davis Nicholas T.
Published: September 2021

Democratic values are widely endorsed principles including commitments to protect individual freedoms. Paradoxically, the widespread normativity of these ideas can be used to justify prejudice. With two nationally representative U.S. samples, we find that prejudiced respondents defend another’s prejudiced speech, using democratic values as justification. This vicarious defense occurs primarily among those who share the prejudice and only when the relevant prejudice is expressed. Several different democratic values (e.g., due process, double jeopardy) can serve as justifications—the issue is more about when something can be used as a justification for prejudice and less about what can be used as one. Endorsing democratic values can be a common rhetorical device to expand what is acceptable and protect what is otherwise unacceptable to express in public.
Lessons from the US: Arbitrability of oppression and mismanagement in India
Authors: Chauhan Prakhar N S , Singh Prashant
Published: September 2021

The present paper delves into an often-discussed question, whether oppression and mismanagement disputes are arbitrable. Public policy concerns are cited as the primary reason for justifying the non-arbitrability of oppression and mismanagement disputes. However, while offering such an argument, what needs to be considered is whether an allegation of oppression and mismanagement in itself amounts to oppression and mismanagement and thereby pushing the tribunal to give up its jurisdiction (which is perverse and completely against the principles of competence–competence). In this paper, a thorough analysis of the concept of arbitrability has been undertaken where arguments beyond the notion of arbitrability being limited to public policy considerations have been explored. The research specifically focuses upon how arbitrability grew in terms of a tribunal’s power vis-a-vis à statutory remedy (courts), by looking at the growth of antitrust and securities transaction disputes in the United States of America.
Curating Quality? How Twitter’s Timeline Algorithm Treats Different Types of News
Authors: Bandy Jack , Diakopoulos Nicholas
Published: September 2021

This article explores how Twitter’s algorithmic timeline influences exposure to different types of external media. We use an agent-based testing method to compare chronological timelines and algorithmic timelines for a group of Twitter agents that emulated real-world archetypal users. We first find that algorithmic timelines exposed agents to external links at roughly half the rate of chronological timelines. Despite the reduced exposure, the proportional makeup of external links remained fairly stable in terms of source categories (major news brands, local news, new media, etc.). Notably, however, algorithmic timelines slightly increased the proportion of “junk news” websites in the external link exposures. While our descriptive evidence does not fully exonerate Twitter’s algorithm, it does characterize the algorithm as playing a fairly minor, supporting role in shifting media exposure for end users, especially considering upstream factors that create the algorithm’s input—factors such as human behavior, platform incentives, and content moderation. We conclude by contextualizing the algorithm within a complex system consisting of many factors that deserve future research attention.
Learning From Cervical Cancer Survivors: An Examination of Barriers and Facilitators to Cervical Cancer Screening Among Women in the United States
Authors: Senkomago Virginia , Greek April , Jackson J. Elizabeth , Thomas Cheryll C. , Richardson Lisa C. , Benard Vicki B.
Published: September 2021

Background:

Screening and timely follow-up have lowered cervical cancer incidence in the US; however, screening coverage, incidence, and death rates have remained fairly stable in recent years. Studies suggest that half of women diagnosed with cervical cancer don’t receive appropriate screening prior to diagnosis; cervical cancer survivors can provide crucial insight into barriers and facilitators to screening.

Methods:

Participants were cervical cancer survivors ≥21 years, identified through population-based central cancer registries (CR) in 3 US states or a social network (SN), Cervivor. CR participants completed a mailed survey on screening history, barriers, and facilitators to screening and sociodemographic data. SN participants completed the same survey online.

Results:

CR participants (N = 480) were older, with a lower proportion of non-Hispanic white, married, and insured women compared to SN participants (N = 148). Fifty percent of CR and 79% of SN participants were screened 5 years prior to their diagnoses. Of those screened, 28% in both groups reported not following-up on abnormal results. For both groups, the most frequently identified screening barrier was that participants never imagined they would develop cervical cancer (percent agree CR = 76%; SN = 86%), and the facilitator was wanting to take care of their bodies (CR = 95%; SN = 94%).

Conclusion:

Addressing key barriers to obtaining screening and timely follow-up related to lack of knowledge of cervical cancer risk and screening tests and addressing insurance coverage in the design or modification of interventions may increase cervical cancer screening and lower cervical cancer incidence in the US.
The Self-Rated Writing Skills of Business Majors: Graduating Perceptions and Collegiate Improvement
Authors: Routon P. Wesley , Marinan John , Bontrager Marvin
Published: September 2021

We analyze the self-rated writing skills of graduating business majors and perceptions on how much these skills changed during college. Subjective skill measures may be good proxies of objective skills, and affect outcomes such as career goals, job applications, and graduate school enrollment. The sample includes 436,370 students from 619 different institutions. On average and all else equal, business majors are estimated to be 17.6% less likely to report high writing skills at graduation when compared with other students and 11.5% less likely to report high gains in these skills during college. Average differences across disciplines are often large.
Introducing the YIMBYs: Renters, housing, and supply-side politics in Los Angeles
Authors: Tapp Renee
Published: September 2021

This paper advances debates around the financialization of housing with a case study of Los Angeles’s yes-in-my-back-yard (YIMBY) groups. In response to the post-2008 affordable housing crisis, YIMBYs have emerged in support of orthodox economic policies that deregulate land use, expedite construction, and intensify financial accumulation in rental housing. Using detailed empirical analysis collected from YIMBY housing activists, this paper examines how the market-based logics they advance take root in local land use issues. It focuses specifically on the impact of YIMBYs on existing divisions within urban politics, including the scale at which housing is contested. By conceptualizing the YIMBY position as one that facilitates financialization, this paper reveals the ways financialization is more than a mode of accumulation: it is a political process embedded in the state from the bottom up and inside out.
Is there a Role for Entrepreneurship Education in Veterinary Medicine? A UK Study
Authors: Henry Colette
Published: September 2021

This article examines entrepreneurship education (EE) provision within UK veterinary schools. Applying institutional theory as a critical lens, the core research question centers on whether there is a defined role for EE within veterinary curricula. Qualitative data gathered from veterinary educators, students, and employers are critically analyzed. Areas where veterinary entrepreneurship educators might enhance their offering to improve graduate employability and increase entrepreneurial activity within the sector are identified. The article contributes to extant scholarship by: identifying the challenges associated with introducing EE into Science, Technology, Engineering, Arts, and Mathematic (STEAM) discipline areas such as veterinary medicine; highlighting the value of institutional theory in critiquing EE within veterinary curricula; furthering understanding of how veterinary EE is perceived amongst key veterinary stakeholder groups/“institutions,” and identifying a potential role for veterinary EE. Novel avenues worthy of future research attention are also highlighted.
Social Roles and Organizational Culture: Attributions of Responsibility and Punitiveness for Financial Crime
Authors: Schmidt Marshall R. , McGrimmon Tucker S. , Dilks Lisa M.
Published: September 2021

A white-collar offender’s role and the organizational culture in which the crime occurs affects subjective evaluations of offender culpability. However, how they affect responsibility attributions and punitiveness is unclear. We examine attribution processes by conducting a factorial experiment to test a proposed model. We test attribution theory derived predictions using innovative methods of scale creation and nonparametric analyses. Participants attribute more responsibility and are more punitive of individuals and offenders in organizational cultures where illegality is atypical. Our five proposed dimensions of responsibility are predictive of responsibility attributions, and path analysis shows offender role and offense environment affect how the five dimensions of responsibility affect attributions. Our findings have implications for criminal justice and adjudication processes and corporate regulation.
Broad phenotypic impact of the effects of transgenerational heat stress in dairy cattle: a study of four consecutive generations
Authors: Weller Joel Ira , Ezra Ephraim , Gershoni Moran
Published: September 2021

Background

Global warming has increased the frequency of heat stress in livestock. Although heat stress directly leads to negative effects on production and reproduction traits in dairy cattle, the transgenerational transition of these changes is poorly understood. We hypothesized that heat stress in pregnant cows might induce epigenetic modifications in the developing embryo germ cells, which, in turn, might lead to phenotypic effects in the offspring. Here, we examined whether transgenerational effects of heat stress contribute to the phenotypic expression of economic traits in Israel dairy cattle. Since heat stress in Israel occurs specifically between June and October, first we examined the association of the month of birth of F1 cows (pregnancy of the F0 dam) with the performance of the F2 and F3 female offspring. Then, we calculated an annual heat stress index and examined the association of the heat stress index during the pregnancy of the F0 dam with the performance of her F2 and F3 offspring. Finally, we examined intergenerational interactions of heat stress by comparing the performance of F3 cows according to the pregnancy seasons of the F0 and F1 animals.

Results

We found a significant association of the month of birth, season of pregnancy, and heat stress index of F0 females, with the performance of their F2 and F3 progenies, which suggests a true transgenerational effect. The most significant transgenerational effects were on fat yield and concentration, dystocia, still-birth, and maturation.

Conclusions

These findings suggest that heat stress during pregnancy affects the performance of offspring, regardless of life circumstances in at least the last three generations. Therefore, heat stress can reduce selection efficiency in breeding programs and may have economic significance in livestock.
Genetic diversity and variation of seven Chinese grass shrimp (Palaemonetes sinensis) populations based on the mitochondrial COI gene
Authors: Zhao Yingying , Zhu Xiaochen , Jiang Ye , Li Zhi , Li Xin , Xu Weibin , Wei Hua , Li Yingdong , Li Xiaodong
Published: September 2021

Background

Chinese grass shrimp (Palaemonetes sinensis) is an important species widely distributed throughout China, which is ecologically relevant and possesses ornamental and economic value. These organisms have experienced a sharp decline in population due to overfishing. Therefore interest inP. sinensisaquaculture has risen in an effort to alleviate fishing pressure on wild populations. Therefore, we investigated the genetic diversity and variation ofP. sinensisto verify the accuracy of previous research results, as well as to assess the risk of diversity decline in wild populations and provide data for artificial breeding.

Methods

Palaemonetes sinensisspecimens from seven locations were collected and their genetic variability was assessed based on mitochondrialCOIgene segments. DNA sequence polymorphisms for each population were estimated using DNASP 6.12. The demographic history and genetic variation were evaluated using Arlequin 3.11. At last, the pairwise genetic distance (Ds) values and dendrograms were constructed with the MEGA 11 software package.

Results

Our study obtained sequences from 325 individuals, and 41 haplotypes were identified among the populations. The haplotype diversity (Hd) and nucleotide diversity (π) indices ranged from 0.244 ± 0.083 to 0.790 ± 0.048 and from 0.0004 ± 0.0001 to 0.0028 ± 0.0006, respectively. Haplotype network analyses identified haplotype Hap_1 as a potential maternal ancestral haplotype for the studied populations. AMOVA results indicated that genetic variations mainly occurred within populations (73.07%). Moreover, according to the maximum variation among groups (FCT), analysis of molecular variance using the optimal two-group scheme indicated that the maximum variation occurred among groups (53.36%). Neutrality and mismatch distribution tests suggested thatP. sinensisunderwent a recent population expansion. Consistent with the SAMOVA analysis and haplotype network analyses, theDs andFSTbetween the population pairs indicated that the JN population was distinctive from the others.

Conclusions

Our study conducted a comprehensive characterization of seven wildP. sinensispopulations, and our findings elucidated highly significant differences within populations. The JN population was differentiated from the other six populations, as a result of long-term geographical separation. Overall, the present study provided a valuable basis for the management of genetic resources and a better understanding of the ecology and evolution of this species.
High contiguity de novo genome assembly and DNA modification analyses for the fungus fly, Sciara coprophila, using single-molecule sequencing
Authors: Urban John M. , Foulk Michael S. , Bliss Jacob E. , Coleman C. Michelle , Lu Nanyan , Mazloom Reza , Brown Susan J. , Spradling Allan C. , Gerbi Susan A.
Published: September 2021

Background

The lower Dipteran fungus fly, Sciara coprophila, has many unique biological features that challenge the rule of genome DNA constancy. For example, Sciara undergoes paternal chromosome elimination and maternal X chromosome nondisjunction during spermatogenesis, paternal X elimination during embryogenesis, intrachromosomal DNA amplification of DNA puff loci during larval development, and germline-limited chromosome elimination from all somatic cells. Paternal chromosome elimination in Sciara was the first observation of imprinting, though the mechanism remains a mystery. Here, we present the first draft genome sequence for Sciara coprophila to take a large step forward in addressing these features.

Results

We assembled the Sciara genome using PacBio, Nanopore, and Illumina sequencing. To find an optimal assembly using these datasets, we generated 44 short-read and 50 long-read assemblies. We ranked assemblies using 27 metrics assessing contiguity, gene content, and dataset concordance. The highest-ranking assemblies were scaffolded using BioNano optical maps. RNA-seq datasets from multiple life stages and both sexes facilitated genome annotation. A set of 66 metrics was used to select the first draft assembly for Sciara. Nearly half of the Sciara genome sequence was anchored into chromosomes, and all scaffolds were classified as X-linked or autosomal by coverage.

Conclusions

We determined that X-linked genes in Sciara males undergo dosage compensation. An entire bacterial genome from the Rickettsia genus, a group known to be endosymbionts in insects, was co-assembled with the Sciara genome, opening the possibility that Rickettsia may function in sex determination in Sciara. Finally, the signal level of the PacBio and Nanopore data support the presence of cytosine and adenine modifications in the Sciara genome, consistent with a possible role in imprinting.
A rice mTERF protein V14 sustains photosynthesis establishment and temperature acclimation in early seedling leaves
Authors: Wang Man , Zhou Feng , Wang Hong Mei , Xue De Xing , Liu Yao-Guang , Zhang Qun Yu
Published: September 2021

Background

Plant mitochondrial transcription termination factor (mTERF) family members play important roles in development and stress tolerance through regulation of organellar gene expression. However, their molecular functions have yet to be clearly defined.

Results

Here an mTERF gene V14 was identified by fine mapping using a conditional albino mutant v14 that displayed albinism only in the first two true leaves, which was confirmed by transgenic complementation tests. Subcellular localization and real-time PCR analyses indicated that V14 encodes a chloroplastic protein ubiquitously expressed in leaves while spiking in the second true leaf. Chloroplastic gene expression profiling in the pale leaves of v14 through real-time PCR and Northern blotting analyses showed abnormal accumulation of the unprocessed transcripts covering the rpoB-rpoC1 and/or rpoC1-rpoC2 intercistronic regions accompanied by reduced abundance of the mature rpoC1 and rpoC2 transcripts, which encode two core subunits of the plastid-encoded plastid RNA polymerase (PEP). Subsequent immunoblotting analyses confirmed the reduced accumulation of RpoC1 and RpoC2. A light-inducible photosynthetic gene psbD was also found down-regulated at both the mRNA and protein levels. Interestingly, such stage-specific aberrant posttranscriptional regulation and psbD expression can be reversed by high temperatures (30 ~ 35 °C), although V14 expression lacks thermo-sensitivity. Meanwhile, three V14 homologous genes were found heat-inducible with similar temporal expression patterns, implicating their possible functional redundancy to V14.

Conclusions

These data revealed a critical role of V14 in chloroplast development, which impacts, in a stage-specific and thermo-sensitive way, the appropriate processing of rpoB-rpoC1-rpoC2 precursors and the expression of certain photosynthetic proteins. Our findings thus expand the knowledge of the molecular functions of rice mTERFs and suggest the contributions of plant mTERFs to photosynthesis establishment and temperature acclimation.
Live video from bystanders’ smartphones to medical dispatchers in real emergencies
Authors: Linderoth Gitte , Lippert Freddy , Østergaard Doris , Ersbøll Annette K. , Meyhoff Christian S. , Folke Fredrik , Christensen Helle C.
Published: September 2021

Background

Medical dispatchers have limited information to assess the appropriate emergency response when citizens call the emergency number. We explored whether live video from bystanders’ smartphones changed emergency response and was beneficial for the dispatcher and caller.

Methods

From June 2019 to February 2020, all medical dispatchers could add live video to the emergency calls at Copenhagen Emergency Medical Services, Denmark. Live video was established with a text message link sent to the caller’s smartphone using GoodSAM®. To avoid delayed emergency response if the video transmission failed, the medical dispatcher had to determine the emergency response before adding live video to the call. We conducted a cohort study with a historical reference group. Emergency response and cause of the call were registered within the dispatch system. After each video, the dispatcher and caller were given a questionnaire about their experience.

Results

Adding live video succeeded in 838 emergencies (82.2% of attempted video transmissions) and follow-up was possible in 700 emergency calls. The dispatchers’ assessment of the patients’ condition changed in 51.1% of the calls (condition more critical in 12.9% and less critical in 38.2%), resulting in changed emergency response in 27.5% of the cases after receiving the video (OR 1.58, 95% CI: 1.30–1.91) compared to calls without video. Video was added more frequently in cases with sick children or unconscious patients compared with normal emergency calls. The dispatcher recognized other or different disease/trauma in 9.9% and found that patient care, such as the quality of cardiopulmonary resuscitation, obstructed airway or position of the patient, improved in 28.4% of the emergencies. Only 111 callers returned the questionnaire, 97.3% of whom felt that live video should be implemented.

Conclusions

It is technically feasible to add live video to emergency calls. The medical dispatcher’s perception of the patient changed in about half of cases. The odds for changing emergency response were 58% higher when video was added to the call. However, use of live video is challenging with the existing dispatch protocols, and further implementation science is necessary.
Clinical value of blood markers to assess the severity of coronavirus disease 2019
Authors: Xiao Liu-Niu , Ran Xiao , Zhong Yan-Xia , Li Shu-Sheng
Published: September 2021

Background

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is threatening the world with the symptoms of seasonal influenza. This study was conducted to investigate the patient characteristics and clinical value of blood markers to assess the severity of coronavirus disease 2019 (COVID-19).

Methods

187 patients, diagnosed with COVID-19 (non-severe and severe cases) and admitted to hospital between January 27th and March 8th of 2020, were enrolled in the present study.

Results

A higher proportion of clinical symptoms, including cough, expectoration, myalgia, and fatigue were observed in the non-severe group. The level of white blood cell count, neutrophils, CRP, IL-6 and IL-8 were significantly increased, while the platelet count was remarkedly decreased in the severe group. The risk model based on lymphocyte, IL-6, IL-8, CRP and platelet counts had the highest area under the receiver operator characteristic curve (AUROC). The baseline of IL-6, IL-8 and CRP was positively correlated with other parameters except in the cases of lymphocyte, hemoglobin and platelet counts. The baseline of the platelet count was negatively correlated with other parameters except in the lymphocyte and hemoglobin counts. Additionally, there was no connection between the severity of COVID-19 and cultures of blood, sputum or catheter secretion.

Conclusions

The present study suggested that high leucocyte and low platelets counts were independent predictive markers of the severity of COVID-19.
Comparison of monoclonal antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma: an indirect-comparison Meta-analysis of randomised controlled trials
Authors: Ye Wu , Wu Xia , Liu Xiaoyan , Zheng Xue , Deng Jili , Gong Yuping
Published: September 2021

Background

Many clinical trials have assessed the effect and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma (MM). The treatment outcomes of comparing different MAbs in combination with the above-mentioned agents remained unclear. We performed the meta-analysis to indirectly compare the effect and safety of MAbs targeting CD38, SLAMF7, and PD-1/PD-L1 in combination with bortezomib/immunomodulators plus dexamethasone/prednisone for patients with MM.

Methods

We searched thoroughly in the databases for randomised controlled trials (RCTs) in which at least one of the three MAbs were included. We included eleven eligible RCTs with 5367 patients in the meta-analysis. Statistical analysis was carried out using StataMP14 and Indirect Treatment Comparisons software.

Results

We calculated hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) and relative risk (RR) for overall response rate, complete response (CR) or better, very good partial response (VGPR) or better, VGPR, partial response, stable disease, and grade 3 or higher adverse events among the three groups. The HRs for PFS of the CD38 group vs SLAMF7 group, CD38 group vs PD-1/PD-L1 group, and SLAMF7 group vs PD-1/PD-L1 group were 0.662 (95%CI 0.543–0.806), 0.317 (95%CI 0.221–0.454), and 0.479 (95%CI 0.328–0.699), respectively. The HR for OS of the CD38 group vs SLAMF7 group was 0.812 (95%CI 0.584–1.127). The RR for CR or better in the CD38 group vs SLAMF7 group was 2.253 (95%CI 1.284–3.955). The RR for neutropenia of the CD38 group vs SLAMF7 group was 1.818 (95%CI 1.41–2.344).

Conclusions

Treatment with the CD38 group had longer PFS and better treatment response than that with the SLAMF7 or PD-1/PD-L1 group. In addition, the SLAMF7 group prolonged PFS compared with the PD-1/PD-L1 group and was associated with a lower incidence of grade 3 or higher neutropenia than the CD38 and PD-1/PD-L1 group. In conclusion, MAbs targeting CD38 are the best, followed by those targeting SLAMF7; MAbs targeting PD-1/PD-L1 are the worst when in combination with bortezomib/immunomodulators plus dexamethasone/prednisone for the treatment of MM.
Flap technique-assisted surgeries for advanced retinitis pigmentosa complicated with macular hole: a case report and literature review
Authors: Lee Chia-Ying , Yang Chung-May , Yang Chang-Hao , Hu Fung-Rong , Chen Ta-Ching
Published: September 2021

Background

Full-thickness macular hole (FTMH) is a rare complication in retinitis pigmentosa (RP) patients and may increase intraoperative challenges. Furthermore, lens capsular flap transplantation and inverted internal limiting membrane (ILM) flap were reported to close complicated FTMH successfully. Here, we present a case of bilateral advanced RP complicated by a FTMH treated with a novel lens capsular flap transplantation and inverted internal limiting membrane flap.

Case presentation

A 46-year-old presented to our hospital with a complaint of progressively blurred vision and metamorphopsia in both eyes. Spectral-domain optical coherence tomography revealed a FTMH with retinoschisis in the right eye and another FTMH in the left eye. ILM peeling with inverted ILM flap technique was performed on the right eye and ILM peeling with anterior lens capsular flap technique was performed on the left eye. Post-operative follow-up showed successful closure of the FTMH and improved vision in both eyes.

Conclusions

In our present case, flap-assisted techniques for retinitis pigmentosa with macular hole result in excellent visual and anatomic outcomes.
Case report: an unusual unilateral pterygium — a secondary pterygium caused by parasitosis in the scleral fistula
Authors: Zeng Wenjie , Pan Zhaoyi , Wang Jun , Deng Xianghui , Jiang Wenmin
Published: September 2021

Background

Ocular parasitosis can cause eye damage, which contribute to eye symptoms such as burning, itching and even blindness. It is uncommon to see the parasitosis lying in the sclera layer, neither it causing pterygium. Here, we present an unusual case of a secondary pterygium caused by intrascleral worm.

Case presentation

A 52-year-old women complained about discomfort in right eye for 6 years. Slit-lamp examination indicated a thickened triangular layers of conjunctiva extending from the nasal edge to the cornea. The diagnosis was pterygium in the right eye. To our surprise, after scleral of nasal side exposed, we could see a tiny fistula right in the sclera which lied right under the pterygium, with an alive and motile worm inside. An intrascleral fistula was noted. Then the worm was removed by forceps from the fistula, which was creamy white, thread-like and 1 cm long.

Discussion and conclusions

As far as we known, it is the first case of an intrascleral worm hidden beneath the conjunctiva which caused the secondary pterygium. It is hard to know the etiology of the secondary pterygium which caused by parasitosis in the scleral fistula untill excision surgery. It is hard to imagine the worm was living in the sclera of the patient for a long-time.
Suicidality in individuals with Prader-Willi syndrome: a review of registry survey data
Authors: Peleggi Analise , Bohonowych Jessica , Strong Theresa V. , Schwartz Lauren , Kim Soo-Jeong
Published: September 2021

Introduction

Prader–Willi syndrome (PWS) is a rare, genetic, neurodevelopmental syndrome associated with hyperphagia and early onset obesity, growth and sex hormone insufficiencies, mild-to-moderate intellectual disability, and behavioral challenges such as compulsivity, anxiety, skin picking, social skills deficits and temper outbursts. Given high rates of psychiatric comorbidity and potential risk factors for suicide in PWS, this study sought a first estimate of the prevalence of suicidal ideation (SI) and attempts (SA) in the PWS population and any characteristics associated with suicidality in this population.

Methods

Using the Global Prader-Willi Syndrome Registry, we included all participants who had answered a question about SI. We examined the most recent data from the surveys about social, economic, and demographic factors, genetic subtype, and psychiatric symptoms and treatments. A chi-square analysis was used to compare registry participants who reported SI to those without reported SI.

Results

From 750 included survey respondents, 94 (12.5%) endorsed some history of SI. Of these, 25 (26.6%) also reported a history of SA, with an average age of 16.25 years at their first attempt. Those with a history of SI were predominantly male and adult age, and had higher rates of aggression and psychiatric comorbidities, therapies, and medications.

Conclusions

This study indicates that the rate of SI and SA in PWS is comparable to the general population, and that suicide attempts in PWS typically begin in middle-teenage years. Despite unique challenges, individuals with PWS and their caregivers should be included in screens and psychoeducation for suicide and mental health concerns.
Global, regional, and national prevalence, disability adjusted life years, and time trends for refraction disorders, 1990–2019: findings from the global burden of disease study 2019
Authors: Li He-Yan , Liu Yue-Ming , Dong Li , Zhang Rui-Heng , Zhou Wen-Da , Wu Hao-Tian , Li Yi-Fan , Wang Ya-Xing , Wei Wen-Bin
Published: September 2021

Background

To evaluate global burden of refraction disorders by year, age, region, gender, socioeconomic status and other national characteristics in terms of disability adjusted life years (DALYs) and prevalence from Global Burden of Disease (GBD) study 2019 and World Bank Open Data 2019.

Methods

Global, regional, and national DALY numbers, crude DALY rates, age-standardized DALY and prevalence rates of refraction disorders were acquired from the GBD study 2019. Mobile cellular subscriptions, urban population, GDP per capita, access to electricity and total fertility rate were obtained from the World Bank to explore the factors that influenced the health burden of refraction disorders. Kruskal-Wallis test, linear regression and multiple linear regression were performed to evaluate the associations between the health burden with socioeconomic levels and other national characteristics. Wilcoxon Signed-Rank Test was used to investigate the gender disparity.

Results

Globally, age-standardized DALY rates of refraction disorders decreased from 88.9 (95% UI: 60.5–120.3) in 1990 to 81.5 (95% UI: 55.0–114.8) in 2019, and might fall to 73.16 (95% UI: 67.81–78.51) by 2050. Age-standardized prevalence rates would also reduce to 1830 (95% UI: 1700–1960) by 2050, from 2080 (95% UI: 1870–2310) in 1990 to 1960 (95% UI: 1750–2180) in 2019. In low SDI region, age-standardized DALY rates (equation: Y = 114.05*X + 27.88) and prevalence rates (equation: Y = 3171.1*X + 403.2) were positively correlated with SDI in linear regression respectively. East Asia had the highest blindness rate caused by refraction disorders in terms of age-standardized DALY rates (11.20, 95% UI: 7.38–16.36). Gender inequality was found among different age groups and SDI regions.

Conclusion

Health burden of refraction disorders decreased in recent years, and may continue to alleviate in the next three decades. Older ages, females and lower socioeconomic status were associated with higher refraction disorders health burden.
HPV vaccination uptake and administration from 2006 to 2016 in a commercially insured population of the United States
Authors: Prabhu Vimalanand S. , Bansal Neha , Liu Zhiwen , Finalle Rodney , Sénécal Martin , Kothari Smita , Trowers Kemar , Myers Evan
Published: September 2021

Background

Human papillomavirus (HPV) infection can cause various cancers and can be prevented through vaccination. The American Cancer Society (ACS) has set an HPV vaccination completion target in 13-year-old children to 80% by 2026. While HPV vaccine coverage (proportion ever vaccinated) estimates are available, annual uptakes (proportion initiating vaccine in a year) in the United States (U.S.) are not well-known.

Methods

We analyzed MarketScan® claims database to assess HPV vaccination uptakes in the U.S. among the 9- to 26-year-olds in 2006–2016. The annual uptake was the ratio of the number of enrollees who had a first record of an HPV vaccine during the year, and the number of enrollees of similar age and sex that year.

Results

Uptake was below 1% among children turning 9 and 10 years old during the year. Since 2009 among female and since 2013 among males, the annual uptake has been the highest in those turning 13 years old (19.7% among females and 17.6% among males in 2016). Catch-up vaccination among older adolescents and young adults increased after Advisory Committee for Immunization Practices (ACIP) recommendations, but eventually slowed down as more younger persons were vaccinated. Most young adolescents were vaccinated by pediatricians, whereas young adult women were predominantly vaccinated by obstetricians/gynecologists and young adult males by family physicians. While only about half of the adolescents had well-check visits, the majority of those who initiated HPV vaccination had one the same year.

Conclusion

Continued increase in uptake is needed to reach the ACS 2026 goals.
Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms
Authors: Cheng Jiafen , Xie Zhuangli , Wang Shengyuan , Wen Siwan , Niu Shanshan , Shi Cuiqin , Yu Li , Xu Xianghuai
Published: September 2021

Purpose

To investigate the changes of cough sensitivity in patients with metabolic syndrome and its possible mechanisms.

Method

A total of 29 metabolic syndrome (MetS) patients with OSAHS (group-1), 22 MetS patients without OSAHS (group-2), and 25 healthy controls (group-3) were included. All participants underwent a routine physical examination and completed the gastroesophageal reflux disease questionnaire (GerdQ), and the inflammatory mediator profile were determined. The cough threshold for capsaicin, induced sputum cell count and cell classification, and inflammatory mediators in induced sputum supernatants were compared. The correlation between capsaicin cough sensitivity and various indicators in the MetS population was analyzed.

Results

The minimum concentration of inhaled capsaicin needed to induce ≥ 5 coughs (C5) was significantly different among three groups (H = 14.393, P = 0.001) and lower for group-1 and group-2 than it for group-3 (P = 0.002, P = 0.005). The percentage of neutrophils in induced sputum and the concentrations of calcitonin gene-related peptide (CGRP), substance P (SP), and interleukin 8 (IL-8) in the sputum supernatant of group-1 and group-2 were significantly higher than those of group-3. Besides, the pepsin concentrations were significantly different among the 3 groups (F = 129.362, P < 0.001), which significantly was highest in group-1 (P < 0.001) and lowest in group-3 (P < 0.001). Triglycerides, AHI, pepsin concentration and BMI were risk factors of increased capsaicin cough sensitivity.

Conclusion

Increased capsaicin cough sensitivity in MetS patients is closely related to sleep apnea and gastroesophageal reflux. For patients in MetS patients without OSAHS, gastroesophageal reflux is an important factor for increased capsaicin cough sensitivity. Airway inflammation, especially airway neurogenic inflammation, may also play a role in the pathogenesis of increased capsaicin cough sensitivity.

Trial registration The protocol was registered in the Chinese Clinical Trials Register (http://www.chictr.org.cn/) (ChiCTR1800014768). Written informed consent was obtained from all participants before enrollment.
The association between acromial anatomy and articular-sided partial thickness of rotator cuff tears
Authors: Liu Cen Tao , Miao Jia Qing , Wang Hua , an Ge Heng , Wang Xian Hui , Cheng Biao
Published: September 2021

Background

Acromial anatomy has been found to be correlated with degenerative full-thickness rotator cuff tears in current studies. However, research on the relationship between acromial anatomy and articular-sided partial thickness of rotator cuff tears (PTRCTs) is still lacking. The purpose of this study was to evaluate whether these imaging graphic parameters exhibit any association between acromial anatomy and degenerative articular-sided PTRCTs.

Methods

Between January 2016 and December 2018, a total of 91 patients without a history of trauma underwent arthroscopy as an articular-sided PTRCT group. In the control group, with age- and sex-matched patients, we selected 91 consecutive outpatient patients who underwent shoulder magnetic resonance imaging (MRI) because of shoulder pain and an MRI diagnosis of only synovial hyperplasia and effusion. MRI was used to measure the acromial type, acromiohumeral distance (AHD), lateral acromial angle (LAA), acromion index (AI), and critical shoulder angle (CSA) by 2 independent observers.

Results

The acromion type, AHD and LAA showed no difference between degenerative articular-sided PTRCTs and controls (P = 0.532, 0.277, and 0.108, respectively). AI and CSA were significantly higher in degenerative articular-sided PTRCTs (P = 0.002 and 0.003, respectively). A good correlation was found between AI and CSA to measurement(Pearson correlation coefficient = 0.631).

Conclusions

Our study revealed that higher AI and CSA were found in degenerative articular-sided PTRCTs. Acromial anatomy with a large acromial extension was associated with the occurrence of degenerative articular-sided PTRCTs.
Radiographic and clinical outcomes of surgical treatment of Kümmell’s disease with thoracolumbar kyphosis: a minimal two-year follow-up
Authors: Cheng Hao , Wang Guo-dong , Li Tao , Liu Xiao-yang , Sun Jian-min
Published: September 2021

Background

Up to now in the surgical treatment of Kümmell’s disease combined with thoracolumbar kyphosis, little research has focused on the evaluation of the imaging and clinical outcomes of restoring the normal alignment and sagittal balance of the spine. This study aimed to evaluate the short to mid-term radiographic and clinical outcomes in the treatment of Kümmell’s disease with thoracolumbar kyphosis.

Methods

From February 2016 to May 2018, 30 cases of Kümmell’s disease with thoracolumbar kyphosis were divided into group A and B according to whether the kyphosis was combined with neurological deficits. All of the cases underwent surgical treatment to regain the normal spinal alignment and sagittal balance. The radiographic outcomes and clinical outcomes of the cases were retrospectively evaluated. The sagittal imaging parameters including sagittal vertebral axis (SVA),thoracic kyphosis (TK),thoracolumbar kyphosis (TLK),lumbar lordosis (LL),pelvic incidence (PI),pelvic tilt (PT),and sacral slope (SS) before operation,immediately after operation,and the last follow-up of each case were measured and evaluated. The clinical results included the Oswestry Disability Index (ODI) and the Numerical Rating Scale (NRS) of the two groups. Statistical software SPSS21.0 was used to analyze the data.

Results

In group A: Mean SVA before operation was 75 mm and 26.7 mm at the final postoperative evaluation (P = 0.000); Mean TLK before operation was 39°, and 7.1° at the final postoperative evaluation (P = 0.000); Mean NRS before operation was 4.7, compared with 0.9 at the final postoperative evaluation (P = 0.000). In group B: Mean preoperative SVA was 62.5 mm and decreases to 30.7 mm at the final postoperative evaluation (P = 0.000); Mean TLK before operation was 33°, and 9.7° 2 years post-operation (P = 0.000); Mean NRS prior to surgery was 4.0, and 0.8 at the last follow-up evaluation (P = 0.000). The improvement of the NRS scores of groups A and B was related to the improvement of the cobb angle (P = 0.020); (P = 0.009) respectively.

Conclusion

In the treatment of Kümmell’s disease with thoracolumbar kyphosis,to restore the normal alignment and sagittal balance can obtain a satisfactory radiographic and clinical short and medium-term effects.