bluuebunny/crossref_metadata_2025 huggingface dataset:
Heterogeneity of abdominal obesity in patients with cardiovascular diseases
Authors: Miklishanskaya S. V. , Solomasova L. V. , Orlovsky A. A. , Nasonova S. N. , Mazur N. A.
Published: January 2022

Aim: To assess the content of visceral adipose tissue (VAT) in patients with abdominal obesity and its relationship with metabolic disorders.

Material and methods. Patients with abdominal obesity (n=107) were included in the study. All participants had an assessment of anthropometric parameters (height, weight), calculation of body mass index (BMI), proportion of total adipose tissue and VAT (bioimpedance analyzer), high-density lipoprotein cholesterol (HDL-c) levels, triglycerides, fasting blood glucose, epicardial thickness adipose tissue (two-dimensional echocardiography).

Results. The median share of VAT (bioimpedance method) was 13%. Patients with abdominal obesity are divided by VAT into 2 groups: ≥14% or ≤13%. Patients with VAT≥14% had significantly higher levels of triglycerides (1.76 [1.27; 2.38] mmol / L) and glucose (6.33 [5.78; 7.87] mmol / L), and below HDL-c levels (0.95 [0.85; 1.21] mmol / L) compared with patients with VAT≤13% (1.32 [1.02; 1.50], 5.59 [5, 11; 6.16] and 1.31 [1.07; 1.58] mmol / L, respectively; p<0.001 for all three comparisons). A significant correlation was found between VAT and triglyceride, glucose and HDL-c levels (r=0.40; r=0.40; r=-0.31, respectively; p<0.001).

Conclusion. Persons with abdominal obesity are heterogeneous in the proportion of VAT. The proportion of VAT above the median is associated with metabolic disorders that are significant for the development and progression of atherosclerosis. An increase in BMI in obese individuals is not associated with an increase in VAT and an increase in the severity of metabolic disorders.
COACHING PROGRAM EVALUATION CORDOVA FUTSAL CLUB
Authors: Ade Syahputra Muhamad , Asmawi Moch , Sulaiman Iman
Published: January 2022

This study aims to evaluate the coaching program at the Cordova futsal club, which is one of the sports associations that fosters and develops futsal in South Tangerang in particular and in Indonesia in general. In this evaluation, the research uses a survey method using the CIPP model, namely, Context, Input, Process, Product. The results of this study concluded that: the context stage, the Cordova futsal club coaching program was considered very good, the implementation was carried out according to the Vision and Mission. Then the Goals and Strategic Plans are the guidelines and references in the implementation of the coaching program. The input stage, which involves the performance of associations, coaching and training programs, athletes, availability of trainers, infrastructure and sources of funds is rated Very Good, obtained 82.5%. The process stages include the implementation of the coaching program and the effectiveness of the program implementation is considered good, with an average rating of 80.5%. The last stage, namely the product stage that is evaluated, is the achievement of targets in regional, provincial and national events.
IDENTIFYING ANKLE INJURY PATTERNS OF NETBALL PLAYERS FOR MAINTAIN THEIR HEALTH AND WELLBEING
Authors: Bandara D.M.D.N , Chandana A.W Suraj
Published: January 2022

Netball is a ball game played by two groups of seven players. Its improvement, got from early forms of ball, started in England during the 1890s. By 1960, universal playing guidelines had been institutionalized for the game. The ankle joint is a pivot joint framed between the tibia and fibula and the bone and enables the foot to twist upwards and downwards. The joint likewise permits a modest quantity of pivot. The joint's dependability originates from the basic course of action of the bones and the encompassing tendons. Ankle injuries can transpire at any age. This article surveys epidemiological investigations on ankle injuries in netball, and what are the sorts of ankle injuries, how it's happen and also survey how counteractive action from ankle injuries and aversion strategies. Furthermore, talk about around a few activities that can use for prevent from ankle injuries in netball. The purpose of the study was to investigate the several Ankle injuries of netball players in different countries. The methodology used for this review was based on previously published guidelines.  It included research articles, journals, research publications, reviews and books. Collect all the findings and add the references. Of 47 articles are found and 18 are included in this review essay. Results demonstrate that the ankle injury was the most widely recognized harmed body site in netball and an Ankle sprain was the real lower leg damage happen in Netball. Ankle sprains represent an enormous level of wounds supported in netball. This efficient survey gives a synopsis of the study of disease transmission of ankle damage in Netball.
COMBINATION TRAINING MODEL S OF BASKET BALL - HANDLING FOR 10 YEARS OLD GROUP: A DEVELOPMENT STUDY
Authors: Triani Ersi Yuli , Supriyadi Supriyadi , Widiawati Prisca
Published: January 2022

Penelitian ini bertujuan untuk mengembangkan model latihan kombinasi ball handling bola basket pada anak kelompok usia 10 tahun pada cabang olahraga bola basket. Metode penelitian ini menggunakan prosedur pengembangan dari Sugiyono. Penelitian ini menggunakan tujuh langkah berdasarkan pertimbangan kebutuhan. Subyek yang digunakan adalah anak bola basket kelompok umur 10 tahun klub Human sebanyak 24 anak. Penelitian ini telah melalui uji ahli 3 validator yaitu ahli kepelatihan, ahli bola basket, dan ahli media. Teknik analisis penelitian ini adalah deskriptif persentase, yaitu mengolah data kuantitatif dan kualitatif, instrumen yang digunakan adalah angket kuesioner. Hasil uji coba kelompok kecil sebesar 89%, uji coba kelompok besar sebesar 95%. Produk video latihan kombinasi ball handling sebanyak 16 model latihan telah layak untuk digunakan. Penelitian ini sebatas mengembangkan sebuah produk berupa video, saran penelitian selanjutnya dapat menguji efektivitas produk tersebut.
VO2MAX ANALYSIS ABC RUNNING DRILL WITH TRAINING MASK METHOD USING ANDROID BASED
Authors: Dwi Dicky Reva Apriana Sanga , Budi  , Agustan Boby
Published: January 2022

The purpose of this study was to analyze the effect of ABC Running Drill using Training Mask on increasing Vo2max Android-based. From the research objective, the researcher used the Pretest-Posttest Experiment Design. The research method used is the research and development (RnD) model from Borg and Gall. Population this research is beginner athletes, members of the Unit Kegiatan Mahasiwa (UKM) Track and Field STKIP Muhammadiyah Kuningan totaling 10 people, the sampling technique uses total sampling technique. The research test instrument used to collect data is the 2400 Meter run test (Cooper Test). After getting the data and obtaining it then the data is input into the system to be used as a database on the application, the android application can be downloaded link bit.ly/PDPDickyReva. To analyze the research data using SPSS Version 26, the results of the processing of the Hypothesis Test using the Pearson formula obtained the following data: There is a significant effect after the ABC Running Drill training process using the Training Mask (sig.) 0.00 < 0.05 so it can be concluded that the ABC Running exercise Drill using a Training Mask has a significant effect on increasing vo2max in Track and Field UKM STKIP Muhammadiyah Kuningan.
Experimentation of the Incineration of Paper Waste at the University Press of Ouagadougou (PUO)
Authors: KABORE Boureima , OUEDRAOGO Germain W. P. , YARBANGA Boureima , KAM Sié , BATHIEBO Dieudonné Joseph
Published: January 2022

Waste management and recycling is major problem in our developing countries for several reasons, including population growth. In Burkina Faso, various techniques for treating this garbage exist and among them, we can cite incineration. Incineration is a heat treatment of garbage that reduces the volume of the latter. This work relates to the experimental study of the incineration of paper waste from the incinerator of the University Press of Ouagadougou. The results of this study show that this device is very useful in that it allows the incineration of paper garbage produced by the printing press. It, therefore, has an environmental advantage because its use promotes better management of paper waste.
Optimization of the Refractive Index of Antireflection Coatings on Monocrystalline Silicon Solar Cells for Photovoltaic Application
Authors: Dieye Awa , Niasse El Hadji Abdoulaye , Niasse Oumar Absatou , Diaw Alassane , Pilor Modou , Mbengue Nacire , Diagne Moulaye , Ba Bassirou
Published: January 2022

In this work, the following materials have been chosen as anti-reflection layer, namely hafnium (HfO2), magnesium fluoride (MgF2), silicon oxynitrides (SiOxNy), silicon oxides (SiOx), silicon nitride (Si3N4) and hydrogenated silicon nitride (SiNx:H). The calculations were made on the basis of values of layer thicknesses and refractive indices that allow the phase and amplitude conditions to be respected and amplitude conditions. Numerical simulations have shown that low reflectivities at the surface of the surface of the plane cell coated with a simple layer, can be obtained. For example, for simple coatings materials based on Si3N4 and HfO2, we obtain a value of reflectivity around 3 and 2 % respectively. The structures with multilayer coatings such as MgF2/SiNx:H/Si, give a reflectivity of around 1 %. Thus, the refraction index of the coating is an important parameter that plays a major parameter that plays a major role in the optical properties of materials. The closer the refractive index is close to the index of the substrate or the layer above the substrate, the higher the reflectivity.
Efektivitas Penerapan Pembiayaan Musyarakah Pada Baitul Maal Wa Tamwil (BMT) Bima Kota Magelang
Authors: Fadlillah Mauliya Nur , Khotijah Siti Afidatul
Published: January 2022

The purpose of this study was to determine the effectiveness of the profit-sharing Musyarakah financing procedure at BMT BIMA Magelang. This study is a qualitative research, uses field research. Data collection techniques through interviews, documentation, and observation, while data analysis techniques using descriptive analysis techniques. The results of the study found that the Musyarakah financing procedure at BMT BIMA Magelang has been carried out effectively because it has carried out the financing process according to sharia principles and provisions, namely, an ijab qabul process between the customer and the BMT, the parties who make contracts, an object of the capital agreement, and a transparent ratio distribution of profits and losses. This study shows that for every increase in the use of Musyarakah financing, there is also an increase in the income of BMT BIMA Magelang.
Fluconazole in Hypercalciuric Patients with Increased 1,25(OH)2D Levels: The Prospective, Randomized, Placebo-Controlled, Double Blind FLUCOLITH Trial.
Authors: Bertholet-Thomas Aurélia , Portefaix Aurélie , Flammier Sacha , Dhelens Carole , Subtil Fabien , Dubourg Laurence , Laudy Valérie , Bouar Myrtille Le , Boussaha Inesse , Ndiaye Mariétou , Molin Arnaud , Lemoine Sandrine , Bacchetta Justine
Published: January 2022

BackgroundHypercalciuria is one of the most frequent metabolic disorders associated with nephrolithiasis and/or nephrocalcinosis possibly leading to chronic kidney disease (CKD) and bone complications in adults. Orphan diseases with different underlying primary pathophysiology share inappropriately increased 1,25(OH)2D levels and hypercalciuria, e.g., hypersensitivity to vitamin D and renal phosphate wasting. Their management is challenging, typically based on hyperhydration and dietary advice. The antifungal azoles are known to inhibit the 1α-hydroxylase and therefore decrease 1,25(OH)2D levels; they are commonly used, with well described pharmacokinetic and tolerability data. Fluconazole has been successfully reported to reduce calciuria in patients with CYP24A1 or SLC34A3 mutations, with no safety warnings. Thus, based on these case reports, we hypothesize that fluconazole is effective to decrease and normalize calciuria in patients with hypercalciuria and increased 1,25(OH)2D levels.MethodsThe FLUCOLITH trial is a prospective, interventional, randomized in parallel groups (1:1), placebo-controlled, double blind trial. A total of 60 patients (10-60years) with nephrolithiasis and/or nephrocalcinosis history, hypercalciuria (> 0.1 mmol/kg/d), increased 1,25(OH)2D levels (> 150 pmol/L) and 25-OH-D levels >20 nmol/L, will be included. Inclusions will be performed only from mid-September to the beginning of February to avoid bias due to sunlight-induced vitamin D synthesis. The primary endpoint will be the proportion of patients with normalization of 24-hour calciuria between baseline and 16 weeks, or with a relative decrease of at least 30% of 24-hour calciuria in patients who still display at W16 a 24-hour hypercalciuria. DiscussionThe current challenge is to propose an efficient treatment to patients with hypercalciuria and increased 1,25(OH)2D levels in order to prevent later complications and notably CKD that can ultimately lead to end-stage renal disease. Based on improvement of knowledge in phosphate/calcium metabolism, pathophysiology and genetics, the “off-label” use of fluconazole was recently reported to be useful in hypercalciuric patients with increased 1,25(OH)2D levels. Thus, the FLUCOLITH study is a unique opportunity to develop a new indication of a well-known and not expensive drug in orphan renal diseases, the ultimate objective being the secondary prevention of CKD worsening in these patients. Trial RegistrationClinicalTrial.gov, ID: identifier: NCT04495608. Registered on July 23rd, 2020
Nitrophenyl-group-containing Heterocycles. Part I. Synthesis, Characterization, Anticancer Activity and Antioxidant Properties of Some New 5,6,7,8-tetrahydro-isoquinolines Bearing 3(4)-nitrophenyl Group
Authors: Sayed Eman M. , Hassanien Reda , Farhan Nasser , Aly Hanan F. , Mahmoud Khaled , Bakhite Etify A.
Published: January 2022

Regioselective cyclocondensation of 2,4-diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl/4-nitrophenyl)cyclohexanones 1a,b with cyanothioacetamide afforded the corresponiing 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-(3-nitrophenyl/4-nitrophenyl)-5,6,7,8-tetrahydro-soquinoline-3(2H)-thiones 2a,b in 93-96% yield. Reaction of compounds 2a,b with some ethyl iodide, 2-chloroacetamide (4a) or its N-aryl derivatives 4b-e by refluxing in ethanol, in the presence of slightly excess molar amounts of sodium acetate trihydrate, for one hour gave 3-ethylthio-5,6,7,8-tetrahydro-isoquinoline 3 and (5,6,7,8-tetrahydroisoquinolin-3-ylthio)acetamides 5a-i, respectively. On heating compounds 5b-d,f,g in ethanol containing a catalytic amount of sodium carbonate, they converted into their isomeric 1-amino- 6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamides 6b-d,f,g. Structural formulae of all synthesized compounds were characterized on the basis of their elemental analyses and spectroscopic data. Also, the biological evaluation of the synthesized isoquinolines as anticancer and antioxidant agents have been carried out and the obtained results are reported herein.
When Shape Matters: Using a Simple Mathematical Model to Estimate Critical Area Sizes in Conservation
Authors: de Assis Raul Abreu , Malavazi Mazilio Coronel , Pazim Rubens , Cannale Gustavo , Cecconello Moiseis , Fonseca Odair José Teixeira da
Published: January 2022

In the analysis of anthropogenic impact on the environment arises the question of whether the shapes of preserved habitat fragments play an important role in the conservation of wild species. In this work we use a very simple mathematical model based on a reaction-diffusion equation to analyze the effects of geometric shape and area on the permanence of populations in habitat fragments. Our results indicate that a dimensionless quantity calculated from a combination of biological variables is the main component that determines if the species survives in the preserved fragment and whether its geometric shape is important. We provide a methodology to calculate critical area sizes for which population size is most affected by fragment shape. The calculation is based on four quantitative variables: maximum per capita reproduction rate, per capita mortality rate outside the fragment, carrying capacity in the conserved environment and mobility in the disturbed environment. The methodology is illustrated by a preliminary study, in which the model is used to estimate threshold area sizes for habitat fragments for the threatened species Sapajus xanthosternos .
Description of laminar-turbulent transition of an airfoil boundary layer measured by differential image thermography using directed percolation theory
Authors: Wester Tom , Peinke Joachim , Gülker Gerd
Published: January 2022

Transition from laminar to turbulent flow is still a challenging problem. Recent studies indicate a good agreement when describing this phase transition with the directed percolation theory. This study presents a new experimental approach by means of differential image thermography (DIT) enabling to investigate this transition on the suction side of a heated airfoil. The results extend the applicability of the directed percolation theory to describe the transition on curves surfaces.

The experimental effort allows for the first time an agreement between all three universal exponents of the (1+1)D directed percolation for such airfoil application. Furthermore, this study proves that the theory holds for a wide range of flows, as shown by the various conditions tested. Such a large parameter space was not covered in any examination so far. The findings underline the significance of percolation models in fluid mechanics and show that this theory can be used as a high precision tool for the problem of transition to turbulence.
Achieving Proportional Representation In A Reproductive Health Survey Through Social Media: Process And Recommendations
Authors: McCarthy Ona L , Palmer Melissa J , Gubijev Anasztazia , Wellings Kaye , Mann Sue , Leon Lydia , Callaghan Faye , Patterson Sophie , French Rebecca S
Published: January 2022

Background: The narrative surrounding women’s reproductive health has shifted from a medical model to an emphasis on reproductive well-being over different life-stages. We developed and piloted a tracker survey for monitoring women’s reproductive health and well-being in England, recruiting respondents online. This paper reports on the success of the online recruitment strategies in achieving a sample proportionally representative of the England general population.Methods: Recruitment was through Facebook and Instagram advertisements and dissemination through Twitter and a blog. At the end week one, the sample was reviewed and compared to the 2011 Census England population. From week two, recruitment targeted under-represented groups. Key data were compared with prevalence estimates from the Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).Results: Between 1 July-17 August 2021, 13,962 people initiated the online survey, with 11,578 completing it. Numbers were low initially, but peaked at 1700 survey initiations per day after increasing the daily advertisement budget on day seven. At the end of week one, minority ethnic groups and people without a degree or equivalent were under-represented. From week two, we altered the advertisement settings to show to people whose profile indicated they were a ‘high school leaver’ had ‘up to some high school’, worked in industries that do not typically require a degree or lived in local authorities with a high proportion of ethnic minority residents. This had a modest effect, with the final sample short of proportional representation in terms of ethnicity and education but close in terms of region and age. Compared to Natsal-3, we found consistency in the proportion of respondents reporting an abortion and a live birth in the last year, however, the proportion of our sample reporting ever having experienced infertility was significantly higher than in Natsal-3, as was the proportion of ‘planned’ pregnancies in the last year.Conclusions: It is possible to recruit large numbers of respondents online, relatively quickly, to complete a reproductive health survey. This will be valuable to track reproductive health and well-being at a national level over time. More work is needed to understand reasons for non-response among under-represented groups.
Prevalence and Associated Factors of Chronic Kidney Disease Among Diabetic and Hypertensive Patients at Ambo Town Public Hospitals of West Shewa Zone, Oromia Region, Ethiopia
Authors: Hailu Haimanot Ewnetu , Dinku Belachew , Wondimu Jimmawork , Girma Bilisuma
Published: January 2022

Background: Chronic kidney disease is a global public health important disease that is associated with life threatening outcomes including renal failure and premature mortality unless diagnosed and treated promptly. Diabetes Mellitus and hypertension are the two major causes of chronic kidney disease worldwide. This study is aimed to determine prevalence and associated factors of chronic kidney disease among diabetes mellitus and hypertensive patients at Ambo town public hospitals, EthiopiaMethods: A cross-sectional study was conducted at Ambo University referral and general hospitals on 308 study participants. The participants were interviewed using interviewer administered questionnaire when they come for follow up at a chronic illness follow-up clinic. The patient charts were reviewed to retrieve information regarding medications, blood pressure, serum Creatinine and glucose level. A chronic kidney disease epidemiology collaboration equation was used to estimate Glomerular filtration rate from serum Creatinine. Data were analyzed SPSS version 23 for statistical analysis. Binary logistic regression analysis was used to identify factors associated with chronic kidney disease. Variables with a p-value below 0.2 at bivariable analysis were entered into the multivariable logistic regression model. Multivariable logistic regression analysis was used to examine the association between dependent and independent variable and p-value less than 0.05 was used to declare statistical significance.Results: A total of 308 diabetes mellitus and hypertensive patients were included in the study from Ambo town public hospitals. Of which 156 (50.6%) participants were female with mean (± SD) age of 47.15 ± 12.06 years. The prevalence of chronic kidney disease (stage 3–5) was 20.5% with (95% CI: 16%-25%). Long duration of hypertension (AOR=4.89, 95% CI=1.93-12.40), elevated systolic blood pressure (>140mmHG) (AOR=3.20, 95% CI=1.36-7.51), family history (AOR=3.36, 95% CI=1.56-7.24) and age greater than 55 years (AOR=2.17, 95% CI=1.09-4.31) were predictors of chronic kidney disease.Conclusion: The prevalence of chronic kidney disease was high. Older age, elevated SBP, long duration of hypertension and family history of kidney disease were independent predictors of chronic kidney disease. A preventive plan is mandatory to reduce the disease and complications in the community.
Climate Change and Child Health – Importance of Pediatricians for Parents
Authors: Lagally Lena , Schorlemmer Julia , Edlinger Maximilian , Schoierer Julia , Bose-O’Reilly Stephan
Published: January 2022

Background: Children are among the most vulnerable to suffer from health consequences due to climate change. Parents as caregivers play an important role in protecting them adequately. Pediatricians are regularly seen as highly-trusted health professionals, but it remains unclear whether they are an information source for parents regarding climate change and health. According to the Health Action Process Approach, parents’ risk perception is an important pre-intender for intention building. Methods: A sample of parents (N = 243) living in Germany completed an online, cross-sectional survey distributed in summer 2020. Regarding climate change and health, we asked about information sources, relevance estimation, and risk perception of parents. Multiple linear regression with general and individual risk perception as outcomes were used to analyze the effect of knowledge and personal relevance. Results: Parents seek information about climate change and health primarily via internet and social media. Pediatricians are rarely considered as suitable information source. Parents see the highest risk for their child through increasing air pollutants and stronger UV-radiation. Relevance (β = .52, t = 5.79, p < .001) and knowledge (β = .02, t = .36, p = .72) explain 18.2% of general risk perception (F(5, 208) = 9.25, p < .001, ΔR2 = .13). The effect is lower (13%) for individual risk perception (F(5, 189) = 5.67, p < .001, ΔR2 = .07). Conclusions: Pediatricians can play a valuable role in informing parents about climate change and health; nevertheless, they are not yet seen as suitable information sources by parents. Results demonstrate that knowledge about climate change and health is not sufficient to increase risk perception of parents, but strengthening risk perception is possible through rising relevance estimation. When informing parents about the expected health impact of climate change, this should be considered.
Association Among Spinnbarkeit, Electrical Conductivity, and Crystallization of Cervical Mucus and Pregnancy Rate in Egyptian Baladi Cows
Authors: Mohamed Mahmoud Yassin , El-Hafeez Ahmed Mohamed Abd , Ibrahim Mohamed El-said , Ramadan Mohamed Hussein , Amin Amin Mohamed , Helal Ahmed
Published: January 2022

Alteration of the biophysical and biochemical characteristics of cervical mucus (CM) due to differences in steroid hormones through the estrus cycle leads to different pregnancy rates. This investigation aims to study the possible relationship between CM properties with biochemical profiles, macro-mineral levels, and steroid hormones concentrations, and their effects on pregnancy rates of Egyptian cows. Fourteen Baladi cows were used and synchronized. The model log-likelihood ratio was highly significant (P=0.0009), and reported that the spinnbarkeit (SPK), electrical conductivity (EC), and crystallization (CRS) had significant effect on high pregnancy rate. The 3rd level of SPK (>13.5 cm) and EC (>15 mS/cm) was the highest significant (P=0.0016 & 0.0517, respectively) and a clear positive of estimate marginal effect (20.2543 & 10.6192, respectively) attitude towards the pregnancy rate. However, in case of the CRS, the significant effect was in the first two levels (P=0.0321 & 0.0425, respectively) with a high pregnancy rate, reverse the last 2 levels. Total protein, cholesterol, glucose, potassium, chloride levels, and estradiol concentrations were observed higher with increasing levels of SPK and EC and appearance of typical fern patterns (first two levels of CRS), in contrast to sodium, and progesterone concentrations that decreased with elevating levels of SPK and EC and appearance of atypical fern patterns (last two levels of CRS). There was a close correlation between CM properties and steroid hormones (P4 & E2). So, alterations in CM properties, especially SPK, EC, and CRS, can be utilized to foresee estrus time and, as a result, insemination time.
Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery
Authors: Kataoka Masahiro , Gomi Kuniyuki , Ichioka Ken , Iguchi Takuya , Shirota Tomoki , Makino Arano , Shimada Ko , Maruyama Kiyotomi , Mihara Motohiro , Kajikawa Shoji
Published: January 2022

Background/Aim:
C-reactive protein to albumin ratio (CAR) has been utilized as a prognostic factor in various carcinomas. We investigated the relationship between preoperative, first postoperative day (POD1), and seventh postoperative day (POD7) CARs and the prognosis of patients with colorectal cancer (CRC).
Patients and Methods:
320 patients with CRC who underwent laparoscopic radical resection between May 2011 and December 2016 were enrolled. Patients were selected into two groups, high CAR and low CAR, based on preoperative, POD1, and POD7 CARs. The relapse-free survival (RFS) and overall survival (OS) were compared between groups using propensity score matching.
Results
The high CAR group had a significantly worse RFS and OS (n=72/group, RFS: p<0.001; OS: p=0.002) at POD7 than those in the low CAR group. However, in preoperative and POD1 analysis, no differences were observed.
Conclusion
In patients with colorectal cancer, CAR of POD7 was a significant prognostic factor.
Clinical profile of patients with Seronegative celiac disease
Authors: Rahmanipour Elham , attarian fahimeh , Ghorbani Mohammad , Shahbazkhani Bijan , Ghavami Vahid , Ganji Azita
Published: January 2022

Background
Celiac disease (1) mostly diagnosed base on positive serology and duodenal mucosal atrophy, but some patients have negative serology and their diagnosis have some limitation, it delay in diagnosis likely accompanied a poor prognosis and high risk of developing complications of CD. The aim of this study was determent clinical profile of patients with Seronegative CD (SNCD).
Methods
in this retrospective study, 1115+8 patients, that evaluated for CD with mucosal atrophy included between 2010 to2020. All patients with IgA deficiency other IgG based serology for diagnosis of celiac was done and if these antibodies were negative consider as possible SNCD. If they had positive DQ2-DQ8, and clinical symptoms or had positive challenge test after12 months of GFD were considered as SNCD.
Results
of total 1115 patients 27 (2.4%) had seronegative mucosal atrophy of duodenum and diagnosed as a SNCD (96.2% marsh3), the mean age and BMI in SNCD patients were significantly higher than other CD patients (p<0.05).
Conclusion
The prevalence of SNCD was 2.4% that likely related to over weighting, so clinicians should be considered high possible of seronegative CD in patients with over weighting and mucosal atrophy of duodenum.
Genotype calling and haplotype inference from low coverage sequence data in heterozygous plant genome using HetMap
Authors: Gong Hao , Han Bin
Published: January 2022

Many software packages and pipelines had been developed to handle the sequence data of the model species. However, Genotyping from complex heterozygous plant genome needs further improvement on the previous methods. Here we present a new pipeline available at https://github.com/Ncgrhg/HetMapv1) for variant calling and missing genotype imputation from low coverage sequence data for heterozygous plant genomes. To check the performance of the HetMap on the real sequence data, HetMap was applied to both the F1 hybrid rice population which consists of 1495 samples and wild rice population with 446 samples. Four high coverage sequence hybrid rice accessions and two high coverage sequence wild rice accessions, which were also included in low coverage sequence data, are used to validate the genotype inference accuracy. The validation results showed that HetMap archived significant improvement in heterozygous genotype inference accuracy (13.65% for hybrid rice, 26.05% for wild rice) and total accuracy compared with other similar software packages. The application of the new genotype with the genome wide association study also showed improvement of association power in two wild rice phenotypes. It could archive high genotype inference accuracy with low sequence coverage with a small population size with both the natural population and constructed recombination population. HetMap provided a powerful tool for the heterozygous plant genome sequence data analysis, which may help the discover of new phenotype regions for the plant species with complex heterozygous genome.
Soil Nutrient Balance and Stock on Smallholder Farms at Agew Mariam Watershed in Northern Ethiopia
Authors: Esubalew Tilahun , Amare Tadele , Molla Eyayu
Published: January 2022

IntroductionSoil nutrient balance is used to evaluate the state of soil fertility, rate of nutrient depletion, sustainability of land productivity, the environmental wellbeing of an area, and to take appropriate management decisions. This study was conducted to quantify soil nutrient balance and stocks on smallholder farms at the Agew Mariam watershed in northern Ethiopia in the 2020/21 main season.MethodsInflows and outflows of nitrogen (N), phosphorus (P), and potassium (K) into, and out of barley, tef, and wheat farms were determined through, field measurement, laboratory analysis, and interviews. The balance quantification was done by subtracting nutrient outputs from the inputs. ResultsThe N partial balance of barley, tef and wheat was -66, -9.8, and -50.7 kg ha-1 yr-1 respectively. The P balance was also -5.9, 0.9, and -2.6 kg ha-1 yr-1 for barley, tef, and wheat respectively. Whereas, K balance was -12.3, -3.2, and -5.4 kg ha-1 yr-1 from barley, tef, and wheat respectively. The balance results revealed that N, P, and K had negative values except for P in tef. Grain yield and crop residue removal were the major paths of nutrient loss. The stock of N was 1295, 1510, and 1240 from barley, tef, and wheat kg ha-1respectively. While, the P stock was 63, 18.7, and 27.5, kg ha-1 from barley, tef, and wheat farms respectively. Similarly, K stock was 1092.7, 1059.4, and 1090.6 kg ha-1 from barley, tef, and wheat cropping systems respectively. Conclusions﻿Reversing the imbalance between inflows and outflows via adding organic and inorganic fertilizers is critically essential for the study area.
Collective Intelligence Under a Volatile Task Environment: a Behavioral Experiment Using Social Networks and Computer Simulations
Authors: Kameda Tatsuya , Naito Aoi , Masuda Naoki
Published: January 2022

Collective intelligence in our highly-connected world is a topic of interdisciplinary interest. Previous research has demonstrated that social network structures can affect collective intelligence, but the potential network impact is unknown when the task environment is volatile (i.e., optimal behavioral options can change over time), a common situation in modern societies. Here, we report a laboratory experiment in which a total of 250 participants performed a “restless” two-armed bandit task either alone, or collectively in a centralized or decentralized network. Although both network conditions outperformed the solo condition, no sizable performance difference was detected between the centralized and decentralized networks. To understand the absence of network effects, we analyzed participants’ behavior parametrically using an individual choice model. We then conducted exhaustive agent-based simulations to examine how different choice strategies may underlie collective performance in centralized or decentralized networks under volatile or stationary task environments. We found that, compared to the stationary environment, the difference in network structure had a much weaker impact on collective performance under the volatile environment across broad parametric variations. These results suggest that structural impacts of networks on collective intelligence may be constrained by the degree of environmental volatility.
SARS-CoV-2 delta AY.1 variant cluster in an accommodation facility for COVID-19: Research study
Authors: Ohishi Takayuki , Yamagishi Takuya , Kurosu Hitomi , Kato Hideaki , Takayama Yoko , Anan Hideaki , Kunishima Hiroyuki
Published: January 2022

Background

This is a case report on a cluster infection of novel severe acute respiratory syndrome coronavirus 2 delta AY.1 variant at an accommodation facility and the subsequent attempts to isolate individuals who tested positive.
Methods

The background that facilitated this cluster was investigated, and the conditions in which infection was established, the infection route, and the effectiveness of routine measures were evaluated. Ninety-nine staff members had been working at the accommodation facility at the time of infection, and it was estimated that 10 members were infected with the delta AY.1 variant.
Results

Our results suggest that infection of staff from a patient staying overnight should be excluded. The factors contributing to the cluster infection involved short-distance conversations with individuals wearing non-woven three-layer masks moved out of position (non-woven) and gathering together with individuals wearing non-woven masks in hypoventilated conditions. Our findings also indicate that this variant is possibly airborne and can infect individuals in enclosed spaces with poor ventilation, even when either infected or exposed individuals wear non-woven masks.
Conclusions

The routine maintenance of systems established for the detection of infections and prompt and appropriate preventive measures following the identification of positive individuals will help prevent further cluster infections.
Deletion of YLR358C Contributes to Reduce Cell Wall Integrity in Saccharomyces Cerevisiae
Authors: Zhang Yu , Li Mengyan , Wang Hanying , Deng Juqing , Liu Jianxing , Zhang Li , Lyu Lechun
Published: January 2022

The mechanism of fungal cell wall synthesis and assembly is still unclear. Saccharomyces cerevisiae (S. cerevisiae) and pathogenic fungi are conserved in cell wall construction and response to stress signals, and often respond to cell wall stress through activated cell wall integrity (CWI) pathways. Whether the YLR358C open reading frame regulates CWI remains unclear. This study found that the growth of S. cerevisiae with YLR358C knockout was significantly inhibited on the medium containing different concentrations of cell wall interfering agents Calcofluor White (CFW), Congo Red (CR) and sodium dodecyl sulfate (SDS). CFW staining showed that the cell wall chitin was down-regulated, and transmission electron microscopy also observed a decrease in cell wall thickness. Transcriptome sequencing and analysis showed that YLR358C gene may be involved in the regulation of CWI signaling pathway. It was found by qRT-PCR that WSC3, SWI4 and HSP12 were differentially expressed after YLR358C was knocked out. The above results suggest that YLR358C may regulate the integrity of the yeast cell walls and has some potential for application in fermentation.
Experimental Study of Pore Permeability Characteristics Based On Variable-Mass System In Karst Collapse Pillars
Authors: Pang Mingkun , Zhang Tianjun , Liu Rongtao , Wang Haotian
Published: January 2022

Particle loss is the root cause for the occurrence of Karst Collapse Pillars (KCP) sudden water events. The pore adjustment of KCP filler will further induce seepage destabilization, and it is also a process that sudden water catastrophe must go through. In order to investigate the direct relationship between stress conditions, water pressure conditions, and gradation structure on the pore structure of rock samples, the steady-state percolation method was used to investigate the percolation test system of variable-mass crushed rock masses. The results show that: 1) the structural characteristics of rock grains under the same stress environment are closely related to their extrusion fragmentation process and the softening and scouring effect of water. Rubbing, rotating, fracturing, grinding and plugging are the main forms of action of their intergranular action. 2) The filling particles before and after the loss meet the fractal law and have fractal characteristics. 3) The percentage of fine particles in the whole process of infiltration loss is as high as 34.4%. The adjustment of pore structure is related to the particle size gradation, and the reciprocal action of water flow will form a stable water-conducting channel. 4) The sudden water process of the specimen under particle loss can be divided into three stages: initial seepage, catastrophic destabilization and pipe flow surge.
How Do We Enhance Oncology Nurses’ Caring Utilizing Resilience And Professional Quality of Life?: A cross-Sectional Descriptive Study
Authors: Jeon Misun , Kim Sanghee , Kim Sue
Published: January 2022

Background: Degree of caring behavior in oncology nurses is a crucial factor in caring for patients with cancer. It is important to understand factors related to oncology nurses' caring including their own resilience and professional quality of life. The purpose of this study was to investigate oncology nurses’ resilience, professional quality of life, and caring.Methods: A cross-sectional descriptive correlational study was conducted on 107 oncology nurses using self-report questionnaires. Data analysis included descriptive statistics, Pearson's correlations, and stepwise multiple regression to examine factors affecting oncology nurses’ degree of caring behavior, using SPSS/WIN 20.0 program (IBM).Result: Oncology nurses presented a low level of resilience and degree of caring behavior, a high level of compassion satisfaction, burnout, and secondary traumatic stress. There was a statistically significant relationship between degree of caring behavior, resilience (r = .43, p < .001), compassion satisfaction (r =.51, p < .001), and burnout (r = -.42, p < .001) as well as between secondary traumatic stress and burnout (r = .34, p < .001). Factors affecting oncology nurses’ degree of caring behavior were compassion satisfaction and education level. Conclusions: This study demonstrated that oncology nurses’ degree of caring behavior relates to professional quality of life, and education. This association suggests several implications for nursing practice to encourage holistic nursing. It will be necessary to study the factors affecting nurses' compassion satisfaction, and to try to promote compassion satisfaction according to the study.
Pretreatment C-reactive Protein to Albumin Ratio Predicts Clinical Outcomes in Patients with Peripheral T-cell Lymphoma
Authors: Jung Jongheon , Heo Ja Yoon , Lee Eunyoung , Lee Hyewon , Chang Myung Hee , Park Ju-Hyun , Eom Hyeon-Seok
Published: January 2022

Peripheral T-cell lymphoma (PTCL) is an aggressive and heterogenous T-cell lymphoid malignancy. The prognostic value of C-reactive protein-to-albumin ratio (CAR) has never been assessed in PTCL. This study retrospectively reviewed the medical records of 76 patients diagnosed with various subtypes of PTCL. The value of 0.794 was identified as the most discriminative point of CAR, and clinical outcomes, including response rate, overall survival (OS), and progression-free survival (PFS), were compared between the high (>0.794, n=25) and low (≤0.794, n=51) CAR groups. After induction therapy, complete response was achieved in 39 patients (76.5%) and 8 patients (32.0%) in the low and high CAR groups, respectively (p<0.001). During the median follow-up of 57.5 months, the high CAR group had significantly worse 5-year PFS (6.6% vs. 43.8%, p<0.0001) and 5-year OS (20.2% vs. 62.2%, p<0.0001) rates. With adjustment for the International Prognostic Index (≥3), Prognostic Index for PTCL-unspecified (≥3), and T cell score (≥2), high CAR remained a significant prognostic factor for PFS (hazard ratio [HR]: 4.01, 95% confidence interval [CI] 2.04–7.86, p<0.001) and OS (HR: 2.97, 95% CI: 1.33–6.64, p=0.008). CAR might play a complementary role in predicting prognosis in patients with PTCL, considering its simplicity, objectivity, and easy accessibility.
Gender and Leg-dominance Differences in Shoe Properties and Foot Injuries in Badminton
Authors: Shen Siqin , Lam Wing-Kai , Teng Jin , Jia Sheng-Wei , Baker Julien S. , Ugbolue Ukadike C. , Fekete Guszáv , Gu Yaodong
Published: January 2022

Background: While the roles of injury prevention and performance enhancement have increasingly been investigated for badminton footwear, there is a lack of research on gender-specific badminton footwear. The purpose of this study was to examine the gender differences in footwear demands and foot injuries in badminton. Methods: A supervised questionnaire survey of 326 recreational badminton players was collected. The questionnaire was divided into four sections enquiring about the characteristics of (1) participant profiles, (2) importance of shoe properties (3) shoe complaints. (4) and pain or discomfort in different foot regions. The Mann-Whitney U test and Wilcoxon Signed Ranks test were performed to determine the differences between genders and the differences between leg dominance, respectively. The significance level was set at 0.05.Results: Both males and females rated shoe fit as the most important features, followed by overall comfort, and injury protection. Females considered forefoot cushioning, comfort, breathability and color as the more important compared with other properties, which showed distinct pattern differences from males. The shoe problem results indicated that plantar pain of the non-dominant foot was considered the most commonly reported footwear problem by both males and females. The problem of excessive arch-support on the dominant and non-dominant sides of male participants was significantly higher than females (p < 0.05). Occasional pain or frequent pain were mainly distributed in the forefoot, followed by the rearfoot and midfoot regions.Conclusion: There were small differences in footwear demand between the dominant and non-dominant sides, but several differences existed between females and males. The results from gender differences suggested that female specific shoes prefer a specific better fit, rather than a modified version of male shoes. In the future, the design of badminton shoes should consider footwear demands and foot discomfort profiles in respective male and female badminton players.
Induced microearthquakes predict permeability creation in the brittle crust
Authors: Li Ziyan , Elsworth Derek , Wang Chaoyi
Published: January 2022

Fracturing controls rates of mass, chemical and energy cycling within the crust. We use observed locations and magnitudes of microearthquakes (MEQs) to illuminate the evolving architecture of fractures reactivated and created in the otherwise opaque subsurface. We quantitatively link seismic moments of laboratory MEQs to the creation of porosity and permeability at field scale. MEQ magnitudes scale to the slipping patch size of remanent fractures reactivated in shear - with scale-invariant roughnesses defining permeability evolution across nine decades of spatial volumes – from centimeter to decameter scale. This physics-inspired seismicity-permeability linkage enables hybrid machine learning (ML) to constrain in-situ permeability evolution at verifiable field-scales (~10 m). The ML model is trained on early injection and MEQ data to predict the dynamic evolution of permeability from MEQ magnitudes and locations, alone. The resulting permeability maps define and quantify flow paths verified against ground truths of permeability.