bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Material from An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers
Authors: Chen Weihsu C. , Yuan Julie S. , Xing Yan , Mitchell Amanda , Mbong Nathan , Popescu Andreea C. , McLeod Jessica , Gerhard Gitte , Kennedy James A. , Bogdanoski Goce , Lauriault Stevan , Perdu Sofie , Merkulova Yulia , Minden Mark D. , Hogge Donna E. , Guidos Cynthia , Dick John E. , Wang Jean C.Y.
Published: April 2023

Supplemental Methods Supplemental Table 1 Supplemental Figures 1-6 1. Pretreatment with cytarabine potentiates the effects of FED in AML xenografts. Supplemental Figure 2. PF cytometry analysis of AML samples. Supplemental Figure 3. Immunophenotypic and phosphoprotein signaling heterogeneity of AML patient samples. Supplemental Figure 4. PF analysis of validation cohort samples Supplemental Figure 5. Effects of FED treatment on FLT3 activity. Supplemental Figure 6. Effects of FED and DAS treatment on pSTAT5, pSRC and pTyr in BCR-ABL1+ AML samples. Supplemental Table 1: Characteristics of patient samples studied in initial and validation cohorts.
Supplementary Methods and Figures 1 - 11 from BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs
Authors: Fox Joanna L. , Storey Alan
Published: April 2023

Supplementary Figure S1. Controls for co-immunoprecipitation of BAK-BMX complex. Supplementary Figure S2. Immunoprecipitation of BMX protein from HT1080 cells did not detect BAX associated with BMX. Input for immunoprecipitation reaction is 10% starting protein. Supplementary Figure S3. Representative images of proximity ligation in situ assay (PLISA) in HT1080 cells. Supplementary Figure S4. Immunoprecipitation of BMX protein from HT1080 cells used in in vitro kinase assay (Figure 1E). Input for immunoprecipitation reaction is 10% starting protein. Supplementary Figure S5. Representative images of BMX immunostaining in sections of prostate cancer tissue microarrays showing examples of low and high BMX reactivity in tumor tissue. Supplementary Figure S6. Immunoprecipitation of PTPN21 from HT1080 cells, then western blotted for BMX showing PTPN21-BMX interact in our model system. Supplementary Figure S7. Determination of PTPN21 knockdown in HT1080 cells following A) siRNA or B) shRNA treatment by qRT-PCR. Change in C(T) relative to the parental cells is plotted (for siRNA n=2, + range; for shRNA n=3, + SD). Supplementary Figure S8. A) Knockdown of PTPN21 increases BAK activation in response to UV damage. B) Knockdown of PTPN21 using 2 different shRNA sequences increases BAK activation in response to camptothecin damage. Supplementary Figure S9. Mean percentage of cells undergoing apoptosis as determined by Annexin V positivity by FACS analysis of HT1080 cells stably transfected with shRNA HuSH43 to knockdown PTPN21 expression over a 24 hour time course of CPT treatment (n=3, + SEM, * p<0.05). Supplementary Figure S10. Silencing of BMX expression in HT1080 cells. Supplementary Figure S11. BMX over-expression in HT1080 cells.
Supplementary Tables 1 and 2 and Supplementary Figures 1 through 5 from The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations
Authors: Zhang Weiguo , Borthakur Gautam , Gao Chen , Chen Ye , Mu Hong , Ruvolo Vivian R. , Nomoto Kenichi , Zhao Nanding , Konopleva Marina , Andreeff Michael
Published: April 2023

Supplementary Table 1. Gene alterations and cytogenic information of AML patients. Supplementary Table 2. Comparison of IC50s of E6201 and AC220 in murine ITD mutant and TKDs mutant cell lines. Fig. S1. Molecular structures of drugs used in this study. Fig. S2. Normal bone marrow samples (three cases) were treated with indicated concentration of E6201 for 72 hours and apoptosis induction was measured by stained with annexin V-Fluo and counting annexin V positivity using flow cytometry. Fig. S3. Body weight of mice was measured at Day 4, in which the mice started E6201 (n = 11) or vehicle (n = 10) treatment, and Day 18 after MOLM13-Luci-GFP cells injection. Fig. S4. Baf3-ITD+691 cells were treated with E6201 for 1 hour and protein profiling of correlated signaling pathways was determined using immunoblotting. Fig. S5. OCI/AML3 and MOLM13 p53 knock down (KD) cells and their respective controls were treated with E6201 for E6201 for 72 hour and apoptosis induction were assessed as the percentage of annexin V-positive cells by flow cytometry.
Supplementary Figure 3 from Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis
Authors: Nakajima Kosei , Kho Dhong Hyo , Yanagawa Takashi , Harazono Yosuke , Hogan Victor , Chen Wei , Ali-Fehmi Rouba , Mehra Rohit , Raz Avraham
Published: April 2023

Mouse osteoclast precursor expresses and secretes endogenous Gal-3.
Supplemental Figure 3 from STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis
Authors: Jones Laura M. , Broz Miranda L. , Ranger Jill J. , Ozcelik John , Ahn Ryuhjin , Zuo Dongmei , Ursini-Siegel Josie , Hallett Michael T. , Krummel Matthew , Muller William J.
Published: April 2023

Supplemental Figure 3:Stat3flx/flx/MTB/MIC tumors are unable to colonize the lungs in the presence or absence of an innate immune system
Supplementary Figure 2 from Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis
Authors: Nakajima Kosei , Kho Dhong Hyo , Yanagawa Takashi , Harazono Yosuke , Hogan Victor , Chen Wei , Ali-Fehmi Rouba , Mehra Rohit , Raz Avraham
Published: April 2023

Human and Mouse osteoclast precursor cells express Gal-3.
Supplementary Figure 1 from Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis
Authors: Nakajima Kosei , Kho Dhong Hyo , Yanagawa Takashi , Harazono Yosuke , Hogan Victor , Chen Wei , Ali-Fehmi Rouba , Mehra Rohit , Raz Avraham
Published: April 2023

Gal-3 is involved in osteoclastogenesis in bone tumor microenvironment.
Supplementary Figure S4 from Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis
Authors: Weber Christine , Telerman Stephanie B. , Reimer Andreas S. , Sequeira Ines , Liakath-Ali Kifayathullah , Arwert Esther N. , Watt Fiona M.
Published: April 2023

Frozen wound sections collected 1, 6 and 13 days after wounding
Supplementary Figure 8 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: April 2023

Anti-CSF1 treatment on β3KOM mice
Supplementary Table S1 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: April 2023

Primers for quantitative real-time RT-PCR analysis
Supplementary Figure S3 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: April 2023

MSH2 is downregulated and miR-21 is upregulated in HCV-related human hepatitis tissues.
Supplementary Figure 5 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: April 2023

LPS treatment enhances integrin beta3 ligand binding
Supplementary Figure S1 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: April 2023

Variant filtering process for whole-exome sequencing.
Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: April 2023

Effects of chemokines and TGF-B on T-cell adhesion to recombinant molecules and specific tumor cells (S1); Influence of TGF-B and chemokines on integrin expression and T-cell motility (S2); Tumor slice staining, influence of anti-CD103 on calcium response and ILK phosphorylation and effect of TGF-B and chemical inhibitors on ILK expression and T-cell adhesion (S3); Influence of siRNA-E-cadherin, shRNA-ILK and rTGF-B on CD103, phospho-ILK and TGFBRI polarization (S4); Effects of TGF-B and chemical inhibitors on granzyme B polarization or redirected target cell lysis (S5).
Supplementary tables from Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Authors: Peng Dongjun , Tanikawa Takashi , Li Wei , Zhao Lili , Vatan Linda , Szeliga Wojciech , Wan Shanshan , Wei Shuang , Wang Yin , Liu Yan , Staroslawska Elzbieta , Szubstarski Franciszek , Rolinski Jacek , Grywalska Ewelina , Stanisławek Andrzej , Polkowski Wojciech , Kurylcio Andrzej , Kleer Celina , Chang Alfred E. , Wicha Max , Sabel Michael , Zou Weiping , Kryczek Ilona
Published: April 2023

Supplementary tables: Supplementary Table 1. Patient characteristics (All 3 cohorts) Supplementary Table 2. shRNA Sequences and Real-time PCR primers Supplementary Table 3. Multivariate analysis of overall survival (All 3 cohorts) Supplementary Table 4. Multivariate analysis of overall survival (Cohort 1, HER2+ patients) Supplementary Table 5. Multivariate analysis of overall survival (Cohorts 2 and 3, random patients)
Supplementary Figures S1-S8 from Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis
Authors: Xing Cheng , Lu Xing-Xing , Guo Peng-Da , Shen Tong , Zhang Shen , He Xiao-Shun , Gan Wen-Juan , Li Xiu-Ming , Wang Jing-Ru , Zhao Yuan-Yuan , Wu Hua , Li Jian-Ming
Published: April 2023

Expression of USP4 in CRC cell lines (S1); Knockdown of USP4 impairs CRC cell proliferation (S2); The degree of USP4 depletion in tumors (S3); Depletion of USP4 inhibits pulmonary metastasis in nude mice (S4); PRL-3 is indispensable for the oncogenic functions of USP4 (S5); USP4 does not affect PRL-3 mRNA expression (S6); Expression of USP4 does not Correlate with PRL-3 mRNA Levels (S7); USP4 protein levels is positively correlated with PRL-3 protein levels in xenografts (S8).
Supplementary Figure 2 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo
Authors: Lohse Stefan , Meyer Saskia , Meulenbroek Laura A.P.M. , Jansen J.H. Marco , Nederend Maaike , Kretschmer Anna , Klausz Katja , Möginger Uwe , Derer Stefanie , Rösner Thies , Kellner Christian , Schewe Denis , Sondermann Peter , Tiwari Sanjay , Kolarich Daniel , Peipp Matthias , Leusen Jeanette H.W. , Valerius Thomas
Published: April 2023

EGFR Expression on target cells were evaluated using 1 µg/ml cetuximab and FITC-labeled goat-anti human IgG antibody by indirect immunofluorescence and flow cytometry.
Supplementary Figure S7 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: April 2023

Supplementary Figure S7. Catenin-ÃŽ' protein levels depict an increase in the GC tissues.
Supplementary Figure S4 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: April 2023

Supplementary Figure S4. miR-29s inhibitors suppress the expression of endogenous miR-29s in GC cells.
Supplementary Figure S3 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: April 2023

Supplementary Figure S3. Enforced expression of miR-29s in MGC803 and HGC27 cells.
Supplementary Figures from Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity
Authors: Finnberg Niklas K. , Gokare Prashanth , Navaraj Arunasalam , Lang Kuhs Krystle A. , Cerniglia George , Yagita Hideo , Takeda Kazuyoshi , Motoyama Noboru , El-Deiry Wafik S.
Published: April 2023

Supplementary Figures 1-9. Sup. Fig. 1: IV injections of the monoclonal DR5-targeting MD5-1 antibody in combination with fluorouracil (5-FU) and CPT-11 sensitizes mice to chemotherapy-induced toxicity. Area-under-the curve (AUC) analysis of weight loss curves following different doses of fluorouracil (5-FU). Sup. Fig. 2: High dose treatment with the DR5-targeting antibody MD5-1 in combination with low-dose CPT-11 triggers liver toxicity whereas low dose MD5-1-treatment combined with high dose chemo triggers GI-toxicity in mouse strains known to be resistant to TRAIL-R-targeting. Sup. Fig. 3: Targeting of DR5 in combination with radiochemotherapy does not trigger synergistic bone marrow toxicity. Sup. Fig. 4: DR5-targeting sensitizes human small intestinal epithelial cells to cell death following chemotherapy. Sup. Fig. 5: DR5-targeting in combination with chemotherapy triggers cell death in the crypts of the GI tract in mice in vivo. Sup. Fig. 6: P53-dependent gene expression changes in the mouse colonic epithelium following fluorouracil and irinotecan. Affymetrix gene expression mRNA data on p53-responsive genes in the colon of mice treated with 5-FU (A) and CPT-11 (B). Sup. Fig. 7: Chemotherapy-dependent reliance on cell cycle regulating- and apoptosis-signaling genes for the toxic response following chemotherapy and DR5-targeting. Sup. Fig. 8: Chk2 is a modulator GIT following combined chemotherapy and DR5-targeting. Sup. Fig. 9: Pharmacologic targeting of Chk2 countermeasure GIT without impacting the anti-tumor response following chemotherapy and DR5-targeting.
Supplementary Table S3 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: April 2023

Differentially expressed promoters.
Supplementary Methods from p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem–like Features via miR-885-5p Control
Authors: Meier Claudia , Hardtstock Philip , Joost Sophie , Alla Vijay , Pützer Brigitte M.
Published: April 2023

Description of additional experimental procedures used in the study.
Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Authors: Mazzieri Roberta , Pietrogrande Giovanni , Gerasi Laura , Gandelli Alessandro , Colombo Piergiuseppe , Moi Davide , Brombin Chiara , Ambrosi Alessandro , Danese Silvio , Mignatti Paolo , Blasi Francesco , D'Alessio Silvia
Published: April 2023

This file include more detailed Material and Methods
Supplementary Figures S1-S4 from Antitumor Properties of an IgG2-Enhanced Next-Generation MET Monoclonal Antibody That Degrades Wild-Type and Mutant MET Receptors
Authors: Yang Yan , Mandiyan Sreekala , Robinson Brett S. , McMahon Gerald
Published: April 2023

Anti-MET antibodies demonstrated no agonistic activities in proliferation assay (S1); Sequence alignment of Sema domain β-subunit of human, monkey, canine and murine MET receptors (S2); Effect of KTN0073-IgG1, IgG2 and IgG4 antibodies on HGF-dependent MET phosphorylation in U87MG cell (S3); Differential effect of IgG2 isotype switching on KTN0070, KTN0071 and KTN0075 (S4).
Supplementary Figure 3 from The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
Authors: Astudillo Luisana , Da Silva Thiago G. , Wang Zhiqiang , Han Xiaoqing , Jin Ke , VanWye Jeffrey , Zhu Xiaoxia , Weaver Kelly , Oashi Taiji , Lopes Pedro E.M. , Orton Darren , Neitzel Leif R. , Lee Ethan , Landgraf Ralf , Robbins David J. , MacKerell Alexander D. , Capobianco Anthony J.
Published: April 2023

IMR-1 treatment does not induce weight loss in treated mice.
Supplementary Figure 2 from The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
Authors: Astudillo Luisana , Da Silva Thiago G. , Wang Zhiqiang , Han Xiaoqing , Jin Ke , VanWye Jeffrey , Zhu Xiaoxia , Weaver Kelly , Oashi Taiji , Lopes Pedro E.M. , Orton Darren , Neitzel Leif R. , Lee Ethan , Landgraf Ralf , Robbins David J. , MacKerell Alexander D. , Capobianco Anthony J.
Published: April 2023

IMR-1 inhibits tumor growth in OE19 xenograft tumor.
Supplementary Figure 1 from The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
Authors: Astudillo Luisana , Da Silva Thiago G. , Wang Zhiqiang , Han Xiaoqing , Jin Ke , VanWye Jeffrey , Zhu Xiaoxia , Weaver Kelly , Oashi Taiji , Lopes Pedro E.M. , Orton Darren , Neitzel Leif R. , Lee Ethan , Landgraf Ralf , Robbins David J. , MacKerell Alexander D. , Capobianco Anthony J.
Published: April 2023

Primary screen of CADD-derived compounds.
Figure S6 from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: April 2023

Typical pictures of orthotopic xenograft bladder cancer model with 5637/Nkx2.8 RNAi and 5637/Nkx2.8 RNAi/Twist1 RNAi cells
Supplementary Table 1 from Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas
Authors: Shakeri Ramin , Malekzadeh Reza , Nasrollahzadeh Dariush , Pawilta Michael , Murphy Gwen , Islami Farhad , Sotoudeh Masoud , Michel Angelika , Etemadi Arash , Waterboer Tim , Poustchi Hossein , Brennan Paul , Boffetta Paolo , Dawsey Sanford M. , Kamangar Farin , Abnet Christian C.
Published: April 2023

Association of different combinations of four antibodies (CagA, VacA, NapA, and GroEL) with gastric adenocarcinoma and its subtypes.
Figure S4 from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: April 2023

Ablation of Twist1 restores the inhibitory effect of Nkx2.8 on the invasiveness of Nkx2.8-silenced UC cells
Figure S7 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: April 2023

Figure S7. Representative examples of RASSF1A and RhoA immunostaining in primary and metastasized breast tumors and adjacent normal tissues.
Figure S6 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: April 2023

Figure S6. A Smurf1-dependency of RASSF1A suppression of RhoA-driven metastasis. A, The NOD/SCID mice were injected intravenously with A549-pcDNA or A549-RhoA (G14V) cells, which carry either shControl or shSmurf1 constructs. Metastatic nodules in the lungs were counted macroscopically after 20 days post-injection. Data represent the mean {plus minus} SD (n = 5 per group; **, P < 0.01).
Figure S4 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: April 2023

Figure S4. RASSF1A blocks Rhotekin interaction with and activation of RhoA. A, Enhanced RhoA-Rhotekin interaction in RASSF1A-depeletd cells. HeLa cells transfected with siControl or siRASSF1A (20 nM) were maintained in the absence of serum for 24 h. At 12 h after serum addition, immunoprecipitation and immunoblot were performed as indicated. B, Rhotekin suppression of RASSF1A-induced RhoA ubiquitination. A549 cells were co-transfected with WT-RASSF1A and Myc-Rhotekin and immunoprecipitation assays were performed to measure ubiquitinated RhoA level. C, RASSF1A inhibition of Rhotekin's protective effect on RhoA ubiquitination. D, No effect of RASSF1A-R269F on RhoA ubiquitination. E, IP assay showing RhoA interaction with Rhotekin and S100A4. F, No effect of RASSF1A on S100A4 protein level. G, RASSF1A suppression of S100A4 activation of RhoA signaling.
Figure S3 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: April 2023

Figure S3. Smurf1-dependent RASSF1A stimulation of RhoA ubiquitination. A, RASSF1A promotes RhoA degradation in a Smurf1-dependent manner. HCT116 cells were transfected with siSmurf1 and/or RASSF1A-V5 and then treated with CHX (10 Î¼M) for the indicated times. B, Stimulation of RhoA ubiquitination by RASSF1A but not by RASSF1C. A549 cells were co-transfected with His-Ub and RASSF1A-V5 or RASSF1C-V5. After 48 h transfection, cell lysates were subjected to immunoprecipitation and subsequent immunoblot using anti-His and anti-RhoA, respectively. C. Inhibition of RASSF1A-induced RhoA ubiquitination by siSmurf1-3UTR transfection and rescue of RhoA ubiquitination by siRNA-nontargetable Smurf1 transfection. siSmurf1-3UTR (5'-GGTGTTCTAGAAGCCCGTT-3') was designed to target the 3'-UTR region of Smurf1 transcript. D, A critical role of Smurf1 for RASSF1A-induced RhoA ubiquitination. A549 cells were co-transfected with RASSF1A-V5 and either WT- or DN-Smurf1 and cell lysates were prepared at 48 h post-transfection. Based on RhoA immunoblot, equal amounts of RhoA (input) were subjected to immunoprecipitation and subsequent immunoblot was performed using anti-His. E, Identification of the HECT domain of Smurf1 as a critical region for the interaction with RASSF1A. A549 cells were co-transfected with Flag-tagged Smurf1 deletion mutants and RASSF1A-V5 and their interaction was determined by immunoprecipitation assays. F, Schematic representation of RASSF1A binding to Smurf1 and RhoA via the N-terminal 69-82 resides and the C-terminal 256-277 residues, respectively.
Supplemental Informaiton from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Authors: Miftakhova Regina , Hedblom Andreas , Semenas Julius , Robinson Brian , Simoulis Athanasios , Malm Johan , Rizvanov Albert , Heery David M. , Mongan Nigel P. , Maitland Norman J. , Allegrucci Cinzia , Persson Jenny L.
Published: April 2023

Supplemental Materials and Methods and figure text for supplemental figures
Supplemental Figure 7 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: April 2023

AKT inhibition does not alter JPO2 mRNA levels
Supplemental Figure 6 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: April 2023

AKT inhibition does not alter survival of JPO2-expressing MB cells
Supplemental Figure Legends from Notch4 Signaling Induces a Mesenchymal–Epithelial–like Transition in Melanoma Cells to Suppress Malignant Behaviors
Authors: Bonyadi Rad Ehsan , Hammerlindl Heinz , Wels Christian , Popper Ulrich , Ravindran Menon Dinoop , Breiteneder Heimo , Kitzwoegerer Melitta , Hafner Christine , Herlyn Meenhard , Bergler Helmut , Schaider Helmut
Published: April 2023

Supplemental Figure Legends for Supplemental Figures 1 to 5
Supplemental Figure 4 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: April 2023

JPO2 is a LEDGF/p75 responsive gene
Suplemental methods from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
Authors: Agnihotri Sameer , Golbourn Brian , Huang Xi , Remke Marc , Younger Susan , Cairns Rob A. , Chalil Alan , Smith Christian A. , Krumholtz Stacey-Lynn , Mackenzie Danielle , Rakopoulos Patricia , Ramaswamy Vijay , Taccone Michael S. , Mischel Paul S. , Fuller Gregory N. , Hawkins Cynthia , Stanford William L. , Taylor Michael D. , Zadeh Gelareh , Rutka James T.
Published: April 2023

Suplemental methods for experiments appearing in supplemental data and expanded details from methods in main manuscript.
Suplemental Figure Legends from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
Authors: Agnihotri Sameer , Golbourn Brian , Huang Xi , Remke Marc , Younger Susan , Cairns Rob A. , Chalil Alan , Smith Christian A. , Krumholtz Stacey-Lynn , Mackenzie Danielle , Rakopoulos Patricia , Ramaswamy Vijay , Taccone Michael S. , Mischel Paul S. , Fuller Gregory N. , Hawkins Cynthia , Stanford William L. , Taylor Michael D. , Zadeh Gelareh , Rutka James T.
Published: April 2023

Suplemental Figure Legends for supplemental data
Supplemental figure 5 from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: April 2023

qPCR analysis of EpCAM, CD133, and CD44 expressions in response to TAZ knockdown.
Supplemental Figure 5: Immune cell infiltration in intestinal tumors and cytokine expression in small intestinal organoids upon MS-444. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: April 2023

CD8+ cytotoxic T-lymphocytes, NKp46+ natural killer cells and F4/80+ macrophages in tumors of AOM/DSS and APCMin mice. Analysis of cytokines secreted by small intestinal organoids upon MS-444 treatment.
Supplementary Table from Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial
Authors: Duggan Catherine , Tapsoba Jean de Dieu , Wang Ching-Yun , McTiernan Anne
Published: April 2023

Supplementary Table 1: Change in PAI-1, VEGF, and PEDF by tertiles of change in percent body-fat compared to controls
Supplementary Figure 8 from Checkpoint Antibodies but not T Cell–Recruiting Diabodies Effectively Synergize with TIL-Inducing γ-Irradiation
Authors: Hettich Michael , Lahoti Jayashree , Prasad Shruthi , Niedermann Gabriele
Published: April 2023

High tumor cell load increases apoptosis susceptibility of CD8 T cells.
Supplementary Methods and References from Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens
Authors: Uttam Shikhar , Pham Hoa V. , LaFace Justin , Leibowitz Brian , Yu Jian , Brand Randall E. , Hartman Douglas J. , Liu Yang
Published: April 2023

Supplementary Methods and References: Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S6 from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors
Authors: Kress Theresia R. , Pellanda Paola , Pellegrinet Luca , Bianchi Valerio , Nicoli Paola , Doni Mirko , Recordati Camilla , Bianchi Salvatore , Rotta Luca , Capra Thelma , Ravà Micol , Verrecchia Alessandro , Radaelli Enrico , Littlewood Trevor D. , Evan Gerard I. , Amati Bruno
Published: April 2023

RNA Pol II intensities on promoters vary between control and tumor samples and correlate with gene deregulation.
Supplementary Figure 3 from Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome
Authors: You Sungyong , Knudsen Beatrice S. , Erho Nicholas , Alshalalfa Mohammed , Takhar Mandeep , Al-deen Ashab Hussam , Davicioni Elai , Karnes R. Jeffrey , Klein Eric A. , Den Robert B. , Ross Ashley E. , Schaeffer Edward M. , Garraway Isla P. , Kim Jayoung , Freeman Michael R.
Published: April 2023

Correlation of the PCS categories with clinical outcomes in individual cohorts displayed by Kaplan-Meier survival curves.
Supplementary Figure 2 from Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome
Authors: You Sungyong , Knudsen Beatrice S. , Erho Nicholas , Alshalalfa Mohammed , Takhar Mandeep , Al-deen Ashab Hussam , Davicioni Elai , Karnes R. Jeffrey , Klein Eric A. , Den Robert B. , Ross Ashley E. , Schaeffer Edward M. , Garraway Isla P. , Kim Jayoung , Freeman Michael R.
Published: April 2023

Differential enrichment of a benign prostate specific gene signature.
Supplementary Figure S3 from Nestin Mediates Hedgehog Pathway Tumorigenesis
Authors: Li Peng , Lee Eric H. , Du Fang , Gordon Renata E. , Yuelling Larra W. , Liu Yongqiang , Ng Jessica M.Y. , Zhang Hao , Wu Jinhua , Korshunov Andrey , Pfister Stefan M. , Curran Tom , Yang Zeng-jie
Published: April 2023

gli3 mRNA expression and cell cycle distribution in NIH3T3 cells and ptch1-deficient GNPs
Supplementary Figure 2 from Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer
Authors: Yan Judy , Ojo Diane , Kapoor Anil , Lin Xiaozeng , Pinthus Jehonathan H. , Aziz Tariq , Bismar Tarek A. , Wei Fengxiang , Wong Nicholas , De Melo Jason , Cutz Jean-Claude , Major Pierre , Wood Geoffrey , Peng Hao , Tang Damu
Published: April 2023

Characterization of the impact of CNTN1 on DU145 and LNCaP C4-2 cell biology
Table and Suppl Figure legends from Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Authors: Cormerais Yann , Giuliano Sandy , LeFloch Renaud , Front Benoît , Durivault Jerome , Tambutté Eric , Massard Pierre-André , de la Ballina Laura Rodriguez , Endou Hitoshi , Wempe Michael F. , Palacin Manuel , Parks Scott K. , Pouyssegur Jacques
Published: April 2023

legend of Table 1 & Table 2 Legends of Supplementary Figures S1, S2, S3, S4 ,S5, S6
Table S2 from Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Authors: Cormerais Yann , Giuliano Sandy , LeFloch Renaud , Front Benoît , Durivault Jerome , Tambutté Eric , Massard Pierre-André , de la Ballina Laura Rodriguez , Endou Hitoshi , Wempe Michael F. , Palacin Manuel , Parks Scott K. , Pouyssegur Jacques
Published: April 2023

Table S2: Analysis of the mutations generated by ZFN in each LS174T-derived cell line used.
Supplemental Methods from Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins
Authors: Hitti Edward , Bakheet Tala , Al-Souhibani Norah , Moghrabi Walid , Al-Yahya Suhad , Al-Ghamdi Maha , Al-Saif Maher , Shoukri Mohamed M. , Lánczky András , Grépin Renaud , Győrffy Balázs , Pagès Gilles , Khabar Khalid S.A.
Published: April 2023

Supplemental methods on statistical correlation modeling, RNA-IP, and Taqman assays.
Supplementary Figures S1-S5 from Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation
Authors: Wang Yan , Hsu Jung-Mao , Kang Ya'an , Wei Yongkun , Lee Pei-Chih , Chang Shing-Jyh , Hsu Yi-Hsin , Hsu Jennifer L. , Wang Hung-Ling , Chang Wei-Chao , Li Chia-Wei , Liao Hsin-Wei , Chang Shih-Shin , Xia Weiya , Ko How-Wen , Chou Chao-Kai , Fleming Jason B. , Wang Huamin , Hwang Rosa F. , Chen Yue , Qin Jun , Hung Mien-Chie
Published: April 2023

Correlation between Gli1 and PRMT1 Levels (S1); Identification of a PRMT1-Methylated Site in Gli1 (S2); Effects of R597 on Gli1 Transcriptional Activity (S3); Tumorigenicity of Wild-Type Gli1 and R597K-Mutated Gli1 (S4); Regulation of Gli1 by PRMT1 Is Independent of SMO/TGF-B/Kras (S5).
Supplementary Table 3 from Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management
Authors: Colli Leandro M. , Machiela Mitchell J. , Zhang Han , Myers Timothy A. , Jessop Lea , Delattre Olivier , Yu Kai , Chanock Stephen J.
Published: April 2023

Conditional logistic regression results for {greater than or equal to}192 NsM and gene mutaations using TCGA Samples
Supplemental Figure Legends from Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant
Authors: Richmond Jennifer , Robbins Alissa , Evans Kathryn , Beck Dominik , Kurmasheva Raushan T. , Billups Catherine A. , Carol Hernan , Heatley Sue , Sutton Rosemary , Marshall Glenn M. , White Deborah , Pimanda John , Houghton Peter J. , Smith Malcolm A. , Lock Richard B.
Published: April 2023

This file contains legends to the 4 supplemental figures.
Supplementary Table 2 from Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management
Authors: Colli Leandro M. , Machiela Mitchell J. , Zhang Han , Myers Timothy A. , Jessop Lea , Delattre Olivier , Yu Kai , Chanock Stephen J.
Published: April 2023

Table shows the information of NCI-Match drugs and genes used on the analysis.
Supplementary Table 1 from Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management
Authors: Colli Leandro M. , Machiela Mitchell J. , Zhang Han , Myers Timothy A. , Jessop Lea , Delattre Olivier , Yu Kai , Chanock Stephen J.
Published: April 2023

Table shows the information for TCGA, ICGC and TumorPortal samples.
Supplementary Tables from Targeting Autocrine CCL5–CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity
Authors: Ban Yi , Mai Junhua , Li Xin , Mitchell-Flack Marisa , Zhang Tuo , Zhang Lixing , Chouchane Lotfi , Ferrari Mauro , Shen Haifa , Ma Xiaojing
Published: April 2023

This table contains patient clinical data and auto rejection rates of 4T1 tumors.
Supplementary Methods from NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem–like Cells in Human Non–Small Cell Lung Cancer
Authors: Zhang Yun , Xu Wei , Guo Huiqin , Zhang Yanmei , He Yuexi , Lee Sau Har , Song Xin , Li Xiaoyan , Guo Yongqing , Zhao Yunlong , Ding Cheng , Ning Fei , Ma Yuanyuan , Lei Qun-Ying , Hu Xiaoyu , Li Shengnan , Guo Wei
Published: April 2023

This file contains additional methods for data in Supplementary Table S1.
Suppl Fig. 6 from Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells
Authors: Sallmyr Annahita , Matsumoto Yoshihiro , Roginskaya Vera , Van Houten Bennett , Tomkinson Alan E.
Published: April 2023

L67 does not induce cleavage of caspases 7 or 9 in HeLa cells.
Suppl Fig. 4 from Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells
Authors: Sallmyr Annahita , Matsumoto Yoshihiro , Roginskaya Vera , Van Houten Bennett , Tomkinson Alan E.
Published: April 2023

Panel A. Induction of gammaH2AX foci in HeLa cells, HeLa Rho minus cells and HeLa cells expressing mitochondrially targeted E. coli DNA ligase by L67. Panel B. N-acetyl cysteine inhibits L67-induced autophosphorylation of ATM in HeLa cells.
Supplementary Figure S6 from Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Authors: Ingle James N. , Xie Fang , Ellis Matthew J. , Goss Paul E. , Shepherd Lois E. , Chapman Judith-Anne W. , Chen Bingshu E. , Kubo Michiaki , Furukawa Yoichi , Momozawa Yukihide , Stearns Vered , Pritchard Kathleen I. , Barman Poulami , Carlson Erin E. , Goetz Matthew P. , Weinshilboum Richard M. , Kalari Krishna R. , Wang Liewei
Published: April 2023

Knockdown of MIR2052HG in ERα-negative cell lines.
Supplementary Figure S4 from Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Authors: Ingle James N. , Xie Fang , Ellis Matthew J. , Goss Paul E. , Shepherd Lois E. , Chapman Judith-Anne W. , Chen Bingshu E. , Kubo Michiaki , Furukawa Yoichi , Momozawa Yukihide , Stearns Vered , Pritchard Kathleen I. , Barman Poulami , Carlson Erin E. , Goetz Matthew P. , Weinshilboum Richard M. , Kalari Krishna R. , Wang Liewei
Published: April 2023

Knock down studies of MIR2052HG.
Supplementary Figure S3 from Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Authors: Ingle James N. , Xie Fang , Ellis Matthew J. , Goss Paul E. , Shepherd Lois E. , Chapman Judith-Anne W. , Chen Bingshu E. , Kubo Michiaki , Furukawa Yoichi , Momozawa Yukihide , Stearns Vered , Pritchard Kathleen I. , Barman Poulami , Carlson Erin E. , Goetz Matthew P. , Weinshilboum Richard M. , Kalari Krishna R. , Wang Liewei
Published: April 2023

Propensity Score Weighted Survival Plot of breast cancer-free interval for patients with rs4476990 and rs3802201 SNPs.
Supplementary Figure 2- Prolonged EMT induction causes modest metastatic outgrowth from Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency
Authors: De Cock Jasmine M. , Shibue Tsukasa , Dongre Anushka , Keckesova Zuzana , Reinhardt Ferenc , Weinberg Robert A.
Published: April 2023

Lung metastases can form after two weeks of continuous induction of the EMT program.
Supplementary material from Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells
Authors: Tsai Chin-Hsien , Tzeng Sheue-Fen , Chao Tai-Kuang , Tsai Chia-Yun , Yang Yu-Chih , Lee Ming-Ting , Hwang Jiuan-Jiuan , Chou Yu-Ching , Tsai Mong-Hsun , Cha Tai-Lung , Hsiao Pei-Wen
Published: April 2023

Supplementary methods and figure legends
Supporting materials and methods from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors
Authors: Jiang Jie , Gui Fu , He Zhixiang , Li Li , Li Yunzhan , Li Shunying , Wu Xinrui , Deng Zhou , Sun Xihuan , Huang Xiaoxing , Huang Wei , Han Shang , Zhang Ting , Wang Zheng , Jiao Bo , Song Siyang , Wang Hongrui , Chen Lanfen , Zhou Dawang , Liu Qiang , Ren Ruibao , Zhang Jianming , Deng Xianming
Published: April 2023

Detailed description for General Chemistry, Cell culture, Antibodies, Plasmid constructs, Establishment of oncogenic kinase transformed Ba/F3 cells, Generation of BRK, EGFR, HER2 knockdown cell lines, Anti-proliferation assay and enzymatic kinase assay, Immunoblotting and immunoprecipitation , Clonogenic assay for the cell-survival experiment, In vivo tumor models, Histological analysis, TUNEL staining, Cell apoptosis assay, Drug combination studies.
Supplementary Figure S2 from Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells
Authors: Tsai Chin-Hsien , Tzeng Sheue-Fen , Chao Tai-Kuang , Tsai Chia-Yun , Yang Yu-Chih , Lee Ming-Ting , Hwang Jiuan-Jiuan , Chou Yu-Ching , Tsai Mong-Hsun , Cha Tai-Lung , Hsiao Pei-Wen
Published: April 2023

Functional signaling by differential genes in 22Rv1-M3 versus 22Rv1 cells analyzed using a bioinformatic approach and transcriptional analysis.
Supplementary figure 5 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
Authors: Chen Justin L. , Walton Kelly L. , Qian Hongwei , Colgan Timothy D. , Hagg Adam , Watt Matthew J. , Harrison Craig A. , Gregorevic Paul
Published: April 2023

Assessing the wasting of specific muscles and tissues of mice injected with rAAV6:activin A and/or rAAV:IL-6.
Supplementary Materials and Methods. from Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14
Authors: Du Yongxing , Liu Ziwen , You Lei , Hou Pengjiao , Ren Xiaoxia , Jiao Tao , Zhao Wenjing , Li Zongze , Shu Hong , Liu Changzheng , Zhao Yupei
Published: April 2023

Detailed information of the materials and methods referenced in this manuscript is shown as supplementary files.
Supplementary Table S5 from Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6
Authors: Choudhury Atish D. , Schinzel Anna C. , Cotter Maura B. , Lis Rosina T. , Labella Katherine , Lock Ying Jie , Izzo Francesca , Guney Isil , Bowden Michaela , Li Yvonne Y. , Patel Jinal , Hartman Emily , Carr Steven A. , Schenone Monica , Jaffe Jacob D. , Kantoff Philip W. , Hammerman Peter S. , Hahn William C.
Published: April 2023

Phoshphopeptides significantly enriched (q<0.25) in cell lysates with doxycycline-induced wild-type NEK6 expression as compared to lysates from cells expressing kinase-dead (kd) NEK6 and as compared to uninduced.
Supplemental Figure 2 from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Authors: Barton Valerie N. , Christenson Jessica L. , Gordon Michael A. , Greene Lisa I. , Rogers Thomas J. , Butterfield Kiel , Babbs Beatrice , Spoelstra Nicole S. , D'Amato Nicholas C. , Elias Anthony , Richer Jennifer K.
Published: April 2023

Limiting dilution tumor size.
supplemental figure s3 from Epstein–Barr Virus-Induced VEGF and GM-CSF Drive Nasopharyngeal Carcinoma Metastasis via Recruitment and Activation of Macrophages
Authors: Huang Di , Song Shi-Jian , Wu Zi-Zhao , Wu Wei , Cui Xiu-Ying , Chen Jia-Ning , Zeng Mu-Sheng , Su Shi-Cheng
Published: April 2023

Figure S3 related to Figure 3. EBV-replicating NPC cells recruit monocytes and activate TAMs via VEGF and GM-CSF respectively.
Figure S4 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Authors: Piacente Francesco , Caffa Irene , Ravera Silvia , Sociali Giovanna , Passalacqua Mario , Vellone Valerio G. , Becherini Pamela , Reverberi Daniele , Monacelli Fiammetta , Ballestrero Alberto , Odetti Patrizio , Cagnetta Antonia , Cea Michele , Nahimana Aimable , Duchosal Michel , Bruzzone Santina , Nencioni Alessio
Published: April 2023

Figure S4 shows that NAPRT is a cytosolic and nuclear protein that regulates cancer cell metabolism and susceptibility to FK866.
Supplementary Table 7 from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
Authors: Yuan Jiang , Jiang Yan-Yi , Mayakonda Anand , Huang Moli , Ding Ling-Wen , Lin Han , Yu Fenggang , Lu Yanan , Loh Thomas Kwok Seng , Chow Marilynn , Savage Samantha , Tyner Jeffrey W. , Lin De-Chen , Koeffler H. Phillip
Published: April 2023

The Highest Expression Genes in NPC Compare With RNA-seq Results From 675 Human Cancer Cell Lines
Tables S1, S2 from Competition between DNA Methylation, Nucleotide Synthesis, and Antioxidation in Cancer versus Normal Tissues
Authors: Cao Sha , Zhu Xiwen , Zhang Chi , Qian Hong , Schuttler Heinz-Bernd , Gong Jianping , Xu Ying
Published: April 2023

Table S1: Tumor samples used in the study; Table S2: CpG sites over the genome.
Table S4 from Competition between DNA Methylation, Nucleotide Synthesis, and Antioxidation in Cancer versus Normal Tissues
Authors: Cao Sha , Zhu Xiwen , Zhang Chi , Qian Hong , Schuttler Heinz-Bernd , Gong Jianping , Xu Ying
Published: April 2023

The model parameters.
Supplemental table 1 from ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas
Authors: Grausam Katie B. , Dooyema Samuel D.R. , Bihannic Laure , Premathilake Hasitha , Morrissy A. Sorana , Forget Antoine , Schaefer Amanda M. , Gundelach Justin H. , Macura Slobodan , Maher Diane M. , Wang Xin , Heglin Alex H. , Ge Xijin , Zeng Erliang , Puget Stephanie , Chandrasekar Indra , Surendran Kameswaran , Bram Richard J. , Schüller Ulrich , Talyor Michael D. , Ayrault Olivier , Zhao Haotian
Published: April 2023

This table provides sequence information for primers and probes used in RT-qPCR.
Supplementary document from Competition between DNA Methylation, Nucleotide Synthesis, and Antioxidation in Cancer versus Normal Tissues
Authors: Cao Sha , Zhu Xiwen , Zhang Chi , Qian Hong , Schuttler Heinz-Bernd , Gong Jianping , Xu Ying
Published: April 2023

Proof of convergence.
Supplemental figure legends from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Authors: Gao Yu , Li Hongzhao , Ma Xin , Fan Yang , Ni Dong , Zhang Yu , Huang Qingbo , Liu Kan , Li Xintao , Wang Lei , Gu Liangyou , Yao Yuanxin , Ai Qing , Du Qingshan , Song Erlin , Zhang Xu
Published: April 2023

detailed illustrations for Supplemental figure1-3
Supplemental Figure 3 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Authors: Gao Yu , Li Hongzhao , Ma Xin , Fan Yang , Ni Dong , Zhang Yu , Huang Qingbo , Liu Kan , Li Xintao , Wang Lei , Gu Liangyou , Yao Yuanxin , Ai Qing , Du Qingshan , Song Erlin , Zhang Xu
Published: April 2023

The quantification of protein expression levels on IHC stained tissue slides in the platform of TissueGnostics GmbH (Vienna, Austria). The results about KLF6 and E2F1 expression are highly consistent with reported scoring system.
Supplemental Figure 1 from Retention of Interstitial Genes between TMPRSS2 and ERG Is Associated with Low-Risk Prostate Cancer
Authors: Murphy Stephen J. , Kosari Farhad , Karnes R. Jeffrey , Nasir Aqsa , Johnson Sarah H. , Gaitatzes Athanasios G. , Smadbeck James B. , Rangel Laureano J. , Vasmatzis George , Cheville John C.
Published: April 2023

Chromosome 21 coverage