bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship of the Low-Density Lipoprotein Cholesterol/High-Density
Lipoprotein Cholesterol Ratio with a Vulnerable Plaque in Patients with
Severe Carotid Artery Stenosis: A Case-Control Study in the Han Chinese
Population
Authors: Qiao Tong , Liu Heqian , Chen Zhipeng , Ding Jiawen , Mamateli Subinuer , Cai Jing
Published: June 2022

Background:

Carotid plaque is often an important factor in ischemic stroke after it changes from stable to vulnerable, and low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) are associated with plaque vulnerability. We aimed to investigate whether the LDL-c/HDL-c ratio, an easily available and novel biomarker, is associated with vulnerable plaques and enhances the warning effect on vulnerability compared to LDL-c or HDL-c alone.

Methods:

We conducted a retrospective study of 187 patients with severe CAS admitted to the Department of Vascular Surgery at Nanjing Drum Tower Hospital from January 2019 to July 2021. They were divided into a stable plaque group and a vulnerable plaque group according to carotid ultrasonography, carotid angiography (CTA), and plaque pathology. Baseline information was collected and compared between the two groups. Correlation analysis was used to determine the degree of correlation between clinical variables. Univariate and multifactor logistic regression analyses were used to examine independent risk factors for vulnerable plaque in patients with severe CAS. Receiver operating characteristic (ROC) curves were used to assess the capacity of LDL-c/HDL-c to predict the occurrence of vulnerable plaque.

Results:

The age of the vulnerable plaque group was 68.12 ± 8.90 years, with 85 males (89.91%); the age of the stable plaque group was 68.77 ± 8.43 years, with 70 males (89.74%). Multivariate logistic regression analysis showed that LDL-c/HDL-c, smoking and diabetes were independent risk factors for vulnerable plaque (all P <0.05). The risk of vulnerable plaque was 4.78-fold greater in the highest LDL-c/HDL-c quartile (≥ 2.63) than in the lowest quartile (≤ 1.31) (P-trend <0.001), and the area under the ROC curve for LDL-c/HDL-c (AUC=0.681, P <0.001) was higher than that for LDL-c and HDL-c.

Conclusions:

LDL-c/HDL-c, smoking and diabetes were independent risk factors for vulnerable plaque in patients with severe CAS, and LDL-c/HDL-c had a higher predictive value for the presence of vulnerable plaque compared with other lipid parameters.
Comparison of the Effect of Jalinus Syrup and Ondansetron Syrup on
Nausea and Vomiting during Pregnancy in Pregnant Women: Randomized
Clinical Trial
Authors: Shayan Arezoo , Nazari Sasan , Nazari Saman , Ahmadinia Hassan , Rahnavardi Mona , Shobeiri Fatemeh , bekhradi Reza , Khalili Arash
Published: June 2022

Objective:

This study aimed to compare the effect of jainus syrup and Ondansetron syrup
on nausea and vomiting during pregnancy.

Methodology:

The present study is a single-blind randomized clinical trial that was conducted on 120 pregnant
women referred to the health centers of Hamadan during 2017-2018. The participants were randomly
divided into two groups, control and intervention, with 60 subjects in each group. Two groups
of 60 received jalinus syrup and Ondansetron syrup for 7 days. Data collection tools, demographic
questionnaire, and information associated with pregnancy, and PUQE-24 questionnaire were used to
assess the severity of nausea and vomiting, and questions related to the assessment of side effects as
well asparticipants’ level of satisfaction with the treatment were provided. All the data were analyzed
using the SPSS software version 16. P-value < 0.05 was considered significant.

Results:

The severity of nausea and vomiting in both groups decreased after the intervention, but
considering the independent t-test, there was no significant difference between the two groups in
terms of severity of nausea (P >0.05). According to the Chi-square test, the severity of nausea of all
participants was moderate in both groups before taking the medication, and after taking the medication,
the severity of nausea reduced in most participants and they were placed in the mild group.

Conclusions:

Due to the similar effects of jalinus syrup and Ondansetron syrup in the treatment of
nausea and vomiting in pregnancy and the absence of side effects arising from its use, herbal medicine
can be used instead of chemical drugs.
Nanomaterials for Diagnosis and Treatment of Lung Cancer: A Review of
Recent Patents
Authors: Kaur Mandeep , Guleria Praveen , Kumar Vineet
Published: June 2022

Background:

Lung cancer is one of the major killers among different kinds of cancer.
Being a silent developer, the earliest detection and treatment of lung cancer is a challenging task.
The existing therapeutic agents have lower efficacy. Nanotechnology can overcome the challenges
posed by conventional approaches to ensure reliable diagnosis and treatment.

Objective:

Various patents on nano diagnosis and nano delivery aspects of lung cancer were analyzed
to compile the information in a nutshell. The increasing trend of patents on nano-based solutions
for lung cancer opens new opportunities.

Methods:

Google patent and Science Citation Index Expanded data sources were used to obtain
relevant literature on nano-detection and nano-drug delivery for lung cancer. Various keywords
were used to ensure the inclusion of recent and most relevant information in each section. The gist
of the patent is described with suitable subsections.

Results:

Thorough review of recent patents on nanotechnology-based theranostics of lung cancer
was conducted. Nanotechnology-based diagnosis and treatment of lung cancer overcome the
drawbacks of traditional treatments with better stability, targeted drug delivery, controlled sustained
drug release, ease of membrane transport, and better therapeutic efficacy/safety ratio to obtain
optimized clinical results. Further, it is cost-effective and accurate.

Conclusion:

Overall, the application of nanotechnology in lung cancer treatment and diagnosis is
a futuristic approach. Furthermore, NPs-based in vitro and in vivo detection and nano drug delivery
to lungs need to be rigorously pursued for a sustainable solution.
Trends of Prevalence Estimates and Risk Factors of Depressive Symptoms among Healthcare Workers Over one Year of the COVID-19 Pandemic
Authors: Yassin Ahmed , Al-Mistarehi Abdel-Hameed , Soudah Ola , Karasneh Reema , Al-Azzam Sayer , Qarqash Aref A. , Khasawneh Aws G. , Alhayk Kefah A. , Al Qawasmeh Majdi , Kofahi Raid M. , Bashayreh Salma Y. , El-Salem Khalid
Published: June 2022

Background:

COVID-19 pandemic has an overwhelming psychologic burden on healthcare workers (HCWs). This study aims to investigate the changes in the prevalence, estimates, severity, and risk factors of depressive symptoms among HCWs within the first year of the COVID-19 pandemic.

Methods:

An observational e-survey collected data on HCWs’ socio-demographic characteristics, occupational situation, and depressive symptoms as measured by Patient Health Questionnaire–9 (PHQ-9). The e-survey was distributed one month after the onset of the COVID-19 pandemic (onset group) and again after one year (one-year group).

Results:

A total of 422 HCWs were included (Mean (SD) age, 35.3 (9.9) years; 71.3% males), with 211 (50%) participants in each group. In the total cohort, the mean PHQ-9 score was 8.5, and 36.7% reported clinically significant levels of depressive symptoms with a PHQ-9 score of ≥10. Compared to the onset group, the one-year group reported a higher risk of major depressive disorder (41.7%vs. 31.8%; OR 1.538; 95%CI 1.032–2.291;p=0.034), a higher mean PHQ-9 score (9.5 (6.8)vs. 7.4 (5.3),p<0.001), and more severe depressive symptoms(p<0.005). Participants who were younger, unmarried, underwent testing for COVID-19, reported lower monthly income, did not receive special COVID-19 education, or had lower satisfaction with institutional preparedness had significantly higher depression scores and symptoms in both onset and one-year groups (p<0.05for each category). Female gender and direct contact with COVID-19 patients or samples were significant risk factors within the onset group. Occupation as a physician, history of COVID-19 testing or infection, and perception of significant changes in work schedule or intensity were significantly associated with higher depression scores and symptoms among the one-year group.

Conclusion:

This study sheds light on an unspoken but significant rise in prevalence estimates and severity of depressive symptoms among HCWs over a year of the COVID-19 pandemic and shows the vulnerable subgroups for whom a psychological intervention might be warranted.
Effect of Captopril and BQ123 Endothelin-1 Antagonist on Experimentally Induced Hyperlipidemic Nephropathy in Rats
Authors: Jaiswal Astha , Semwal Bhupesh Chandra , Singh Sonia
Published: June 2022

Background:

Kidney disease is a universal public health problem, and epidemiological studies demonstrated that the incidences of chronic kidney disease are increasing day by day. However, the efficiency of currently available drugs on the progression of nephropathy is limited. Therefore, the current research was designed to evaluate the therapeutic efficacy of captopril and BQ123 against hyperlipidemia-induced nephropathy in rats.

Objective:

Implication of Endothelin-1 in Experimentally Induced Hyperlipedemic Nephropathy in Rats

Methods:

Animals were divided into various groups, and the administration of a high-fat diet for six weeks induced hyperlipidemia. After confirmation of hyperlipidemia, treatment was started for the next 14 days. At the end of the experimental period, the animals were sacrificed, and various biochemical parameters and histopathological studies were performed.

Results:

Treatment of both the agents in combination effectively decreased BUN levels, serum creatinine, serum nitrite, and proinflammatory markers and ameliorated the pathological injuries of kidneys.

Conclusion:

Furthermore, both treatments also inhibited oxidative stress and restored the hyperlipidemia-induced reduction in the level of antioxidant enzymes.
A Psychosocial Risk Assessment Tool to Predict Postnatal Depression
in Women with Complicated Pregnancy
Authors: Faramarzi Mahbobeh , Hamidia Angela , Kheirkhah Farzan , Basirat Zahra , Ghadimi Reza , Chehrazi Mohammad , Barat Shahnaz , Cuijpers Pim , O'Connor Elizabeth , Mirtabar Seyyedeh Mahboubeh
Published: June 2022

Introduction:

Few studies have reported the role of psychosocial risk factors by a validated scale in predicting mental disorders in women with complicated pregnancy. This study investigated the role of a psychosocial risk assessment tool in the prediction of postnatal depression in women with complicated pregnancy.

Methods:

A prospective study was performed on pregnant women with complicated pregnancy from December 2019 to June 2020. A total of 125 pregnant women filled the Antenatal Risk Questionnaire (ANRQ), Edinburgh Postnatal Depression Scale (EPDS) and Brief Symptom Inventory 53-items (BSI-53). Also, the patients completed EPDS during 6-weeks of postpartum. An expert mental specialist conducted the interviews based on the DSM-5.

Results:

More than half of the women with complicated pregnancy were diagnosed to have at least one mental disorder. The mean risk scores of ANRQ including the childhood social support from the respondent’s mother, history of mental illness, perceived level of support available postpartum, significant life events in the past 12 months, and personality traits with high anxiety were higher in women with mental disorders than those without mental disorders. The results emphasized that the total score of ANRQ was the strongest positive predictor for postnatal depression score of EPDS (β = 0.569, p=<0.001), for the total score of BSI-53 (β = 0.666 p=<0.001), and for GSI (β = 0.237, p=0.019).

Conclusion:

The study proposes that the use of a validated psychosocial risk assessment tool alongside a screening psychological tool, like EPDS, is reliable for prediction of mental disorders and help women with complicated pregnancy at risk for prevention of depression at antenatal visits.
Characterization and Analysis of Polyphenols in Green and Black Tea Brands Available in Commercial Market of Pakistan
Authors: Shafi Javairia , Tahira Fazeelat , Saleem Hina , Asif Muhammad , Mirza Zahid Sharif
Published: June 2022

In present study, the quality of commercial brands of green and black tea available in Pakistan was analyzed on the basis of phenolic contents. Total phenolic content was analyzed through spectrophotometric measurement using the ferrous Tartrate method. Individual catechins along with gallic acid and caffeine were determined using HPLC-UV. TPC of green tea was found to be higher than black tea. Among green tea brands, Lipton Clear Green showed higher TPC than Tapal Gulbahar. Both green and black tea polyphenols showed higher solubility in the aqueous acetone (50%, v/v) compared towater. (-)-EGCG was detected as the most abundant catechins in all green and black tea samples. Theaflavin content of Lipton Yellow Label and Vital was significantly higher than Tapal Family Mixture and Tetley. Based on catechins and theaflavins content, Lipton Clear Green, Lipton Yellow Label, and Vital Tea were considered to be of higher quality than other brands.
Decision Making for Biological Tofu Wastewater Treatment to Improve Quality Wastewater Treatment Plant (WWTP) Using Analytical Hierarcy Process (AHP)
Authors: Simanjuntak Naomi Aurora Margareth Br , Zahra Nurulbaiti Listyendah , Suryawan I Wayan Koko
Published: June 2022

This research aims to build a support system for tofu wastewater treatment using the Analytical Hierarchy Process (AHP)  method. This research was conducted in one of the household tofu industries in Jakarta. AHP method was used to choose/decide the most effective combination of technologies to treat tofu wastewater. Based on the literature study and inlet characterization, Three alternatives were proposed. Alternative 1 consists of a Collecting tank, Neutralization Tank, Preliminary Sedimentation, Anaerobic Digester, Aeration Tank, and Final Settlement Body. While alternative 2 consists of a Collecting tank, Neutralization Tank, Preliminary Sedimentation, Anaerobic Biofilter, Aeration Tank, and Final Settlement Tank. Alternative 3 consists of a Collecting tank, Neutralization Tank, ABR, Aeration Tank, and Final Sedimentation Tank. The decision criteria used for AHP were effluent quality, land requirement, construction cost and easy maintenance. The primary data used were wastewater flow and outlet concentration. While data of area use , maintenance cost and construction cost were extracted from literature study. The result shows that alternative 3 was the most effective sequence of technology.  Eigen Vector Analysis Recapitulation showed that alternative 1 has an overal value of 0.31, alternative 2 has value of 0.2 and alternative 3 has value of 0.5. Using alternative 3, BOD5 can be removed up to 95%, COD can be removed by maximum of  95% by ABR, TSS can be removed by 80% which met the quality standard.
PEMETAAN KELAS KAPABILITAS KESUBURAN TANAH SEBAGAI DASAR IDENTIFIKASI PERMASALAHAN DAN STRATEGI PENGELOLAAN LAHAN SAWAH
Authors: Agustina Christanti , Kusumarini Novalia , Rayes Mochtar Lutfi
Published: June 2022

Farmers' lack of understanding of agricultural land characteristics leads to inaccuracy in farm management. As a result, this research aimed to classify soil fertility capability and design soil management strategies based on the limiting factor. This study took place in Malang Regency's Turen District. Soil samples were taken from 45 observation locations throughout 15 LMUs (Land Map Unit). The Fertility Capability Classification (FCC) technique was used to evaluate soil fertility classification utilizing soil texture, pH, organic C, CEC, cation base (K, Na, Ca, Mg), and base saturation. Turen District was found to have eight fertility capability classifications, including Chm (3-8 %), Chm (8-15 %), CLhm (0-3 %), CLhm (3-8 %), LChm (3-8 %), Lhm (0-3 %), Lhm (3-8 %), and Lhm (8-15 %). Single symbol C is interpreted as clay texture for both top and subsoil, as well as a single symbol for L as loamy texture. Symbol CL is interpreted as clay texture on topsoil and loamy texture on subsoil. Symbol LC is interpreted as loamy texture on topsoil and clay texture on subsoil. Symbol h in FCC class is interpreted as low pH (acid), and symbol m as low organic C. Soil pH and organic C content are the two most important limiting parameters for soil fertility.
PENGARUH PENAMBAHAN BIOCHAR CANGKANG SAWIT DENGAN VARIASI SUHU PIROLISIS TERHADAP EMISI CO2 DARI TOP SOIL
Authors: Sasmita Aryo , Isnaini Isnaini , Almira Ulimaz
Published: June 2022

Soil respiration activity is one of the contributors to carbon dioxide (CO2) emissions from the agricultural sector. The agricultural sector can also reduce the CO2 emissions it produces, one of which is by making biochar from agricultural waste. Palm shells have potential as raw materials for biochar because they contain hemicellulose, cellulose and lignin. The purpose of this study was to study the effect of adding biochar with variations in pyrolysis temperature on CO2 emissions resulting from the soil respiration process. Palm shell biochar was pyrolyzed with temperature variations of 500 oC and 600 oC for 1 hour and activated using NaOH. Biochar was then added to the soil at a dose of 10% and incubated for 25 days which was tested once every five days. The results showed that the highest CO2 emissions occurred from soil respiration activities with the addition of palm shell biochar at a temperature of 600 oC at an incubation time of 5 days, which was 37 mg CO2. This value was 22.95% greater than the control treatment without the addition of biochar.
PERTUMBUHAN DAN HASIL TANAMAN JAGUNG LOKAL VARIETAS MOTOROKIKI PADA BEBERAPA KELAS LERENG DAN DOSIS PUPUK NPK DI PAYU, GORONTALO
Authors: Husain Andri , Baderan Nurdin , Purnomo Sutrisno Hadi
Published: June 2022

Maize local of Motorokiki variety is a Gorontalo germplasm which is cultivated more dominantly on sloping land with low productivity. This study was aimed to determine the growth and yield of local maize on several slope classes and doses of NPK fertilizer, and their combination on the growth and yield of local maize in Payu, Gorontalo. This study used a split-plot design with the main plot of slope class and sub-plots of NPK fertilizer dosage. The main plot of the slope class consisted of flat slopes (0-8%), wavy (8-15%), hilly (15-35%) and mountainous (>35%), while sub-plots with NPK fertilizer dosage consisted of 0 kg ha-1, 50 kg ha-1, 100 kg ha-1, 150 kg ha-1 and 200 kg ha-1. The parameters measured included plant height, leave numbers, male and female flowering age, cob length, and weight of corn kernels. Data were analyzed by the Duncan Multiple Range Test (DMRT) at 5% level. The results showed that maize growth was significantly affected by slope class and NPK fertilizer dosage with the best combination of wavy slope and 50 kg ha-1 fertilizer dosage. In maize yield, only maize seed weight was significantly affected by slope class, while in NPK fertilization only on male and female flowering age with the best combination of flat slope class and 100 kg ha-1 fertilizer dosage.
Penerapan Ruang Fleksibel Terhadap Aktivitas Pengguna Pasar Tradisional Kemakmuran di Kabupaten Kotabaru
Authors: Haryanti Indah Pradnya , Wirasmoyo Wiliarto
Published: June 2022

Market is not supported by good facilities and further strengthens the stigma of traditional markets which are slum, crowded, and the smell becomes strong. This study aims to get rid of the bad image of traditional markets so that it attracts more visitors from various circles and optimizes the function of space in the market. The method used in this research is a rational approach and it is resolved with a flexible space approach applied to the choice of building structure, layout, design of the building, and furniture. The results of the implementation of this flexible space can accommodate all activities in the market according to the needs at certain times without disturbing other ongoing activities with a good zoning division in accordance with SNI Pasar Rakyat, so as to create a clean, neat, organized, and clean market. convenient according to user needs.
Infrastruktur Jalan Sebagai Lahan Parkir Semarang Bridge Fountain Sungai Banjir Kanal Barat (BKB)
Authors: Widianingrum Permata , Sardjono Agung Budi
Published: June 2022

New tourism in Semarang City raises a problem, traffic congestion. New tourism provided in Semarang City by utilizing the existing potensial is Semarang Bridge Fountain. Semarang Bridge Fountain is a dancing fountain located in Semarang City, which inaugurated end of 2018. Located on the West Canal Flood River and becomes new icon in Semarang City. The existence of Semarang Bridge Fountain affects the surrounding road infrastructure. Namely the emergence of traffic jams when the fountain attraction takes place caused by many vehicles parked on Jenderal Sudirman street. The purpose of this research to analyze road infrastructure can be used as parking lots. The method used in this research is descriptive qualitative to explain state of West Canal Flood River. The results of this research shows that parking area became one of problems that arise during event. Many people don’t know location of official parking area provided by City Government. Congestion arises because the community gathers at one point during the event and also does not know the official parking location. From the results of analysis can be concluded need for delivery of official parking location information for community, need for firmness of official parties related arrangement of parking, also the addition of facilities so that activities aren’t concentrated at one point.
Elemen Arsitektural Astana Sunda Kasepuhan Ciptagelar
Authors: Laksana Noeviyanti Indah , Wulandari Lisa Dwi , Kusdiwanggo Susilo
Published: June 2022

Kasepuhan Ciptagelar is a kasepuhan who still holds the ngalalakon tradition. Based on the traces of the movement, the artifacts left are not only settlements or houses but also artifacts that are outside the settlements in the form of astana (tomb). Physically, this astana has differences from other tombs because the astana adapts to environmental conditions. This study aims to identify the architectural elements of Astana Sunda Kasepuhan Ciptagelar, to determine its characteristics. The research method is a qualitative research with descriptive analysis. The results show that the architectural elements of Astana Sunda Kasepuhan Ciptagelar are influenced by Sundanese culture, nature and the environment, with the main character is the use of natural materials around the. The basic form of plan is rectangle, with or without pangkemit. All astana have woven bamboo walls, rectangle windows and doors in several variants, roof in the form of parahu kumureb and Suhunan Jolopon. The original roof are made of palm-fibers, and the ceiling under the roof are using woven bamboo.
Arsitektur Kontemporer Kota Pada Penggal Jalan D. I. Panjaitan, Kampung Cina Bengkulu
Authors: Utami Dwi Rina , Wijono Djoko
Published: June 2022

The old town of Bengkulu has elements of urban architecture with distinctive characteristics, one of which is Chinese Town. .D. I. Panjaitan is the main street of Chinese Town which is busy with vehicles, so it acts as the main image of the area. Over time, various architecture has changed in the area, as evidenced by indications of contemporary city architecture in the form of geometric spaces (building form, solid, void, skyline) and functional spaces (functions of spaces and buildings) so it is very interesting to study. Therefore, this research aims to formulate a contemporary architectural formulation of the city on D. I. Panjaitan street by using qualitative and deductive method with geometric space and functional space approach. This research reveals that the contemporary architecture of the city at D. I. Panjaitan street tends to consist of original chinese architecture on the south side and modern architecture on the south side. The functional space consists of settlement, trade and tourism areas. The character of space tends to be related to Chinese cosmological architecture, namely the concept of Sanqing, Wuxing, Bagua or Feng Shui, Jiugongtu and Jingtianzhi. These formulation shaped due to hictorical influences, policies, location, culture and important event.
Karakter Spasial Ruang Publik sebagai Tempat Ketiga Studi Kasus: Pasar Seni dan Wisata Gabusan
Authors: T.A.K. A.A.Ayu Ratih
Published: June 2022

The third place is a place to unwind, apart from home as the first place and the office as the second place. The third place is one type of public space. Gabusan Art and Tourism Market (PSWG) is a place for art accommodation in Bantul Regency, Yogyakarta. However, in recent years, the situation of PSWG as a public space has declined and is getting worse. It is necessary to conduct research related to the character of the third place as a public space. This qualitative, grounded theory research method uses primary sources: observations and interviews, and secondary sources: literature studies with the third-place theory from Ray Oldenburg. The research variable is that the third-place functions as a public space, a social space and own good accesibility. The stages of the research process starting from secondary data processing, namely literature studies, then primary data processing, namely observations and interviews of activity actors. The research results show that PSWG as a public space is sufficient, but as a third-place it is lacking in terms of social activities and accessibility
Kajian Pola Sebaran dan Perubahan Tipologi Permukiman Desa Celuk – Sukawati Menggunakan Citra Satelit
Authors: Widiantara I Putu Adi , Dwijendra Ngakan Ketut Acwin
Published: June 2022

Celuk Village as an icon of the silver industry in Bali has experienced a significant development of spatial patterns. This is influenced by the geographical location of Celuk Village which is an area bordering the suburbs of the City of Denpasar. Because land reserves that can be occupied in the City of Denpasar are decreasing, this triggers physical development to spread towards the outskirts of the city, thus causing the phenomenon called urban sprawl. Due to the expansion of physical development, as well as changes in rural forms, it will certainly affect the form of settlements and changes in their urban patterns. This study uses a deductive-quantitative method through a case study approach. Geospatial data using satellite imagery from Google Earth is processed through ArcGIS software. The results showed that there were changes in traditional settlements due to the addition of new functions and population growth, as well as the presence of non-traditional buildings as a result of the expansion of the village area due to economic growth, diverse community backgrounds, and urban spatial expansion.
‘Sense of Place’ in Virtual Design Studio (VDS): A Review
Authors: Kusumowidagdo Astrid , Prihatmanti Rani
Published: June 2022

Physical design studio (PDS) and live critique sessions are essential elements in design school pedagogy. It enables students to construct their socio-spatial ability through creativity and rationality in a simultaneous way. However, due to the COVID-19 global pandemic, all teaching and learning activities must be conducted remotely in a virtual design studio (VDS). Unfortunately, VDS could be a placeless place for the students and significantly affects their overall learning experience. ‘Sense of Place’, or the people-place engagement, is an important concept in the virtual learning context from the cognitive, affective, and conative domain. VDS not merely provide the ‘place’, but should be able to support dynamic social interactions between students and the tutors as well as to conduct pedagogical activities. Without ‘Sense of Place’, the emotional and psychological engagement in creating learning experiences could not be fulfilled. This paper reviews the previous studies that concentrate on the pedagogical method and ‘Sense of Place’ in VDS at a higher education level. There are several strategies for constructing ‘Sense of Place’ in a VDS. Those are humanization, socialization, the presence of a teacher, guiding structure, graphic tools used, and the student contribution during the learning process. Another strategy is to blend both online and classroom that encourages teachings with multiple learning styles. This conceptualization of ‘Sense of Place’ in VDS is beneficial in further research with empirical data.
Simulation of a double-circuit subordinated coordinate regulation system of the active po wer factor corrector for the electric locomotive auxiliary electric drive
Authors: Pustovetov M. Yu.
Published: June 2022

Introduction. The object of this study is an auxiliary frequency-controlled electric drive of an AC locomotive, or more specifically, the structure and parameters of the system for regulating the coordinates of the active power factor corrector, which is a part of the electric drive and a unit that ensures the energy efficiency of the electric drive as well as its electromagnetic compatibility with other equipment on board the electric locomotive and the power network. The purpose of the study is to substantiate the structure of the system for regulating the coordinates of an active power factor corrector, the choice of types of regulators and the calculation of their parameters.

Materials and methods. The author has chosen as the research method the calculation of transfer functions of regulators of the subordinated regulation system, followed by computer simulation of the processes in electrical circuits using the OrCAD computer-aided design system.

Results. The author made a conclusion about the expediency of using a two-circuit system of subordinated coordinate regulation containing a voltage control circuit and a current control circuit. The researcher presented and analytically compares the results of modelling of a two-circuit coordinate regulation system for the active power factor corrector for various types of regulators. The models with an aperiodic current regulator and a proportional-integral voltage regulator showed the best results.

Discussion and conclusion. The obtained data serve as the basis for further improvement of the active power factor corrector operation by improving and optimising the settings, structure and algorithms of the control system, which, with the selected hardware components of the power unit, will enable it to perform its functions with a high degree of reliability in the entire range of disturbing and controlling actions on board of an electric locomotive.
Fatmagül Berktay'ın Tek Tanrılı Dinler Karşısında Kadın adlı eserinin değerlendirilmesi / Review of Tek Tanrılı Dinler Karşısında Kadın by Fatmagül Berktay
Authors: Kalkan Sümeyye Esra
Published: June 2022

Fatmagül Berktay, Tek Tanrılı Dinler Karşısında Kadın (4. Baskı, İstanbul: Metis Yayınları, 2012, 233 sayfa). ISBN: 978-975-342-096-9
Laemmle’s Theatre in Gent (1913) Een initiatief van Carl Laemmle, de ‘stichter’ van Hollywood.
Authors: Deseijn Guido
Published: June 2022

Recent kon op de noordzijde van het Koningin Maria Hendrikaplein een tot nu toe onbekend vroeg filmzaaltje als 'buur' en 'voorloper' van de bekende Ciné Rex geïdentificeerd worden. Dit kon via een sterke uitvergroting van een postkaart uit ca. 1913
In de Gentschen Opera.
Authors: Ödberg Frank
Published: June 2022

Een paar anekdotes uit de jaren stillekes.
Charles van Rysselberghe bouwt in Sint-Pieters-Buiten. Deel 4. Een appeltje voor de dorst aan de Koningin Astridlaan en de Lostraat (1904-1920)
Authors: Steeman Jan
Published: June 2022

Bij de aanleg van het eerste gedeelte van de laan bij het Citadelpark maakt Van Rysselberghe van de gelegenheid gebruik om een reeks opbrengstwoningen op te trekken langs de nieuwe
boulevard.
Pareltjes uit het Begijnhof
Authors: Doesselaere Hans
Published: June 2022

Boterprijs in WO I. De Gentse Nachtwacht. Kantienreglement Brandweer. Werkerspensioenkas Brugsche Poort. Kolen voor huisverwarming rantsoenkaart. Belasting op balkons en loggia's
Zieke monniken in de Sint-Baafsabdij te Gent. Monastieke infirmerieën in de middeleeuwen.
Authors: Hanson Marc
Published: June 2022

In dit artikel wordt in algemene termen een beknopte beschrijving gegeven van de zorg voor zieke kloosterlingen in de ‘abdijfermerie’ (infirmerie).
Lezers aan het woord
Authors: Redactie GT
Published: June 2022

Sint-Antonius van Padua. Het Oudburgerke gevelbeeld. Drogist Schokeel in Hoogpoort. Gentse publiciteit- en letterschilders. Valère Billiet. Schilderijen van Jos Trotteyn. Seske(n)s: epilepsie, Pont Madou: Walpoortbrug, Gentse vluchtelingen in Wales (WO I).
Onbekend gebleven ‘Folly’ in Zwijnaarde (Gent). Kunstgrot op het domein De Blekerij, huidige Campus De Deyne.
Authors: De Decker Arthur
Published: June 2022

Op het terrein van de scholencampus De Deyne tussen de wijk Nieuw Gent en de Ringvaart, is een historisch en landschappelijk waardevolle ‘folly’ bedreigd door nieuwbouwplannen van de Broeders van Liefde. Het is een kunstgrot, onderdeel van het gedeeltelijk bewaard gebleven kasteelpark De Blekerij, destijds grondgebied Zwijnaarde.
Succesvolle ontsnapping in 1916 van de Gentse soldaat Désiré van Mansaert uit Duitse krijgsgevangenschap.
Authors: Driesen Johnny , Gelaude Frank
Published: June 2022

Désiré Van Mansaert, jonggehuwde Gentse soldaat, loodgieter in het burgerleven, werd gewond bij de hevige gevechten van november 1914 in het verwoeste Diksmuide. Als krijgsgevangene werd hij door de Duitsers tewerkgesteld en (feitelijk) gevangen gehouden in een metaalconstructiebedrijf in de buurt van Giessen (Westfalen). Na een eerdere mislukte poging kon Désiré in 1916 vluchten en het neutrale Nederland bereiken.
Bomen op de Kouter. Meningen van lanterfanters en ‘kenners’ (1893)
Authors: Van Hulle Hubert
Published: June 2022

Hubert Van Hulle, ontwerper van het Citadelpark, lag aan de basis van het grootste gedeelte van het negentiende-eeuwse bomenbestand langs Gentse wegen en waterlopen binnen de huidige stadsring. De man moet zich enorm geërgerd hebben aan de wijsneuzigheden en het geklets over het stadsgroen, vooral de bomen in zijn tijd. Die kritiek kwam van allerhande betweters zonder ook maar de minste kennis over het onderwerp. Van Hulle reageerde daarop en hij schreef die frustratie van zich af in een hoofdstukje van zijn documentair waardevolle boekje ‘Promenades horticoles au Parc de Gand et dans les plantations publiques en général’.
Lezers aan het woord
Authors: Redactie GT
Published: June 2022

Zwanenridder. Mossels. Katrienspekken. Onderhoud oorlogsgraven. Marie Schellinck. Militaire schuilplaatsen. Valse zuster van Filips de Goede; Stootkarren op de Lievekaai. Kinkee, kilekee, quiquet. Galbert van Brugge. De naam Graslei. ACEC arbeiders. Sterfdatum De Waele.
Oude dozen, opgeëisten en vrouwenrechten
Authors: Vermeirsch Eric
Published: June 2022

Mijmeringen bij een oude foto uit de jaren 1914-1918 waarop een kleine familiegroep te zien is met iets extra: een toegevoegd portretje van iemand die er niet kon bij zijn: een man die door de bezetter opgeëist en weggevoerd werd voor arbeidsdienst in de oorlogsindustrie of achter het front. De Opgeëistenlaan bij het nieuw gerechtsgebouw herinnert aan hen. In deze bijdrage gaat de aandacht vooral naar mijn moeder, die zelfs niet naar de avondschool mocht en trouwde met een textielarbeider, klein zoon van de opgeëiste.
Snapshots van lichte zeden uit het Gentse verleden
Authors: Dousselaere Hans
Published: June 2022

Enkele stukken uit de DSMG collectie met Algemeen Politievoorschriften, Belgradostraat, Verordening-taks op de barmeiden, Belasting op de bardienders en bardiensters. Maison de Société Slosse, rue des couturières
Charles De Buck – Rosalie Vander Waerden en hun katoendrukkerij op de stadsvesten aan de Wondelgemse meersen
Authors: Sabbe Daniël , Devriese Luc
Published: June 2022

Charles De Buck en zijn vrouw Rosalie Vander Waerden vormen een typisch voorbeeld van Gentse textielfabrikanten in de eerste helft van de jaren 1800. Ze waren orangist, maar participeerden evengoed in het pa - ro chieleven en de parochiaal georganiseerde armenzorg. Hun weinig ge - kende bedrijf was een katoendrukkerij gevestigd op een bolwerk tussen de buiten- en de binnengracht van de stadsvesten (Blaisantvest vanaf 1827) wes te lijk van de Muidepoort. Na het opheffen van de stadstollen in 1860 bleef het bedrijfje bestaan aan de stadszijde van de in 1863 gegraven Nieuwe Vaart. Het werd echter aanzienlijk uitgebreid met een katoenspinnerij - weverij aan de andere zijde van het kanaal onder de naam Parmentier - Van Hoegaerden, bij de Gentenaars gekend als de Gès fa brie ke (Gras fa briek). Die bijnaam is afgeleid van de uitgestrekte Wondel gemse Meer sen, locatie van het bedrijf.
Artois neemt brouwerij Meiresonne over (1964).
Authors: Hanson Marc
Published: June 2022

Op 1 januari 1964 nam de brouwerij Artois de al licht verlieslatende
brou werij Meiresonne aan de Gentse Koepoortkaai over. Het Leuvense
bedrijf verwierf een meerderheidsparticipatie en kocht ook de daarmee verbonden naamrechten. Na een overgangsperiode van een tiental jaren moest het Gentse bedrijf sluiten. Haar ligging, geprangd tussen de Schelde en het Gentse stadscentrum, bemoeilijkte trouwens modernisatie en grootschalige expansie.
De schoonste dag van uw leven
Authors: Vermeirsch Eric
Published: June 2022

Velen zullen op de vraag “Wat was de schoonste dag van uw leven?” niet altijd gauw een antwoord kunnen geven. Voor de meesten was het de dag van hun huwelijk (sic), voor anderen een eerstgeborene, voor de overgrote
meerderheid van de huidige generatie Gentenaars de dag waarop de Gantoise eindelijk eens het Belgisch kampioenschap had gewonnen. ’t Leven kan soms zo mooi zijn, de schoonste dag kiezen wordt moeilijker naarmate men ouder wordt.
Café chantant 't Wit Paard en zijn voorganger in Café du Nord.
Authors: Suwijns Rudy
Published: June 2022

Gedetailleerde informatie over twee Gentse cafés. Een op de Vrijdagmarkt en het andere op de Kammerstraat.
ANTITHROBOCYTIC THERAPY IN CORRECTION OF COAGULATION DISORDERS IN TYPE 2 DIABETES MELLITUS
Authors: Yefimov A. S. , Shulyarenko L. V.
Published: June 2022

The article presents the data of the original study of the effectiveness of antiplatelet drugs (aspirin, clopidogregel) in the correction of coagulation

disorders in type 2 diabetes.
MODERN PHYTOTHERAPEUTIC APPROACHES IN ANDROLOGICAL PRACTICE
Authors: Gurzhenko Yu. M.
Published: June 2022

The paper presents a positive experience of using the phytocomplex Kamavit forte by Nutrimed (Ukraine) in the treatment of erectile dysfunction.

The efficiency of phytopreparation treatment was 88.9%.
STUDY OF THE INFLUENCE OF THE ALOPERATIVE PLACENTA ON THE THYROID FUNCTION OF RABBITS
Authors: Malova Nataliya , Komarova Irina , Yurchenko T. M. , Sirotenko Larisa , Brechka Nataliia , Chuikova V. I. , Taranova K. S.
Published: June 2022

The effect of cryopreserved placental biopreparations on the restoration of thyroid function against the background of experimental hypothyroidism has been studied. It is established that

after transplantation of rabbit placenta tissue, the thyroid gland of animals with experimental hypothyroidism has the ability to restore its functional activity for a long time. It is shown that allo-tissue of the placenta has

pronounced stimulating effect on thyroid function of rabbits with suppressed thyroid gland. The maximum effect of the biological product is two months

term and is stored in the third month of the allograft in the body

the recipient.
NEW APPROACHES TO THE TREATMENT OF THYROID CANCER WITH TRACHEA INVASION: THE USE OF CRYODESTRUCTION
Authors: Hulchiy M. V. , Karachentsev Yuri , Oliynyk O. B. , Tsimbalyuk S. M.
Published: June 2022

The extrathyroid distribution is observed in 4–16 % cases of highly differentiated thyroid cancer; it is marked by a great resistance to the treatment and worst prognoses. The resection of trachea is considered to be the method of choice under the condition of intraluminal trachea invasion. The socalled «shaving excision» is widely used for the treatment of extraluminary invasion. To decrease the risk of local recurrent of tumour growing after the procedure of «shaving excision» the authors of the article have proposed to use the additional cryodistruction towards the area of trachea invasion as an efficient and safe method of devitalization of microfoci of tumour in trachea wall.
THE INFLUENCE OF OXYTOCIN ON PRO- AND ANTIOXIDANT STATE AT DIABETIC ANIMALS
Authors: Trzhetsinskiy S. D.
Published: June 2022

The aim of the investigation was to study the influence of course central and peripheral oxytocinintroduction on the state of pro- and antioxidant systems in healthy and diabetic animals. It isfound out that oxytocin introduction promotes the decrease of the activity of free radical oxidation process in erythrocytes in healthy animals. In diabetic animals, which were administered oxytocin by, the significant decrease of the content of primary, secondary and definitive products of peroxide lipid acidification has been observed. It has been registered on the background of the increase of catalase and glutationreductase activities and the increase of α-tocopherol content. These changes of antioxidant components activity of erythrocytes defense were actually higher in the process of central introduction of neuropeptide. The results observed show the antioxidant activity of oxytocin that may be realized through the intensification of antioxidant defense processes
THE LONG-TERM INTERNATIONAL NON-INTERVENTIONAL STUDY IN PEOPLE WITH TYPE 2 DIABETES TREATED WITH INSULIN. ANALYSIS OF BASELINE OF UKRAINIAN POPULATION (CREDIT — Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy)
Authors: Poltorak V. V. , Gorshunska Maryana , Shemetilo A. V.
Published: June 2022

In this long-term international non-interventional study we performed analyses of baseline data from the Ukrainian population of DM type 2 patients, enrolled in the CREDIT study (n = 149), who were treated with insulin whatever the regimen for more than 1 month and less than 6 months prior the study entry. Baseline demographic characteristics of subjects at insulin initiation were the following: age (mean ± SD) 57.7 ± 8.9 years ranging from 37 to 99; 54.4 % were women and 45.6 % men. Average duration of diabetes was 7.5 ± 5.3 years ranging from 0 to 27 years; 37.6 % of subjects (n = 56) had a duration of their diabetes from 5 to 10 years. Body mass index was 30.2 ± 5.2 kg/m2 . Most recent HbA1c test either within the last year or not more than 1 month after insulin initiation was 10.1 ± 2.2 % (n=146), and a value of HbA1c > 10.0 % was found in 43.8 % subjects (n = 64). Average FBG was 222.3 ± 64.3 mg/dL, and FBG > 100 mg/dL was found in 99,3 % (n = 144) of the subjects. PPG was recorded in 142 subjects and was on average 259.7 ± 69.2 mg/dL. Treatment regimens at insulin initiation were: basal insulin alone in 53.0 % (n = 79) of subjects, basal+short acting insulin in 16.8 % of subjects, premix insulin alone in 26.9 % of subjects, short acting insulin alone in 2.0 % and other in 1.3 % of subjects. Before insulin initiation, 36.2 % of subjects (n = 54) received 1 antidiabetic medicine except insulin; 53.0 % of subjects (n = 79) had bitherapy; no treatments — in 8.1 % (n = 12). Insulin was initiated in 46.2 % of patients treated with biguanides and in 43.4 % of patients treated with sulfonylureas. Basal insulin regimen had been initiated in patients with an HbA1c of 10.1 ± 2.0 %, a FBG of 217.5 ± 62.8 mg/dL, a PPG of 254.6 ± 65.8 mg/dL (a duration of diabetes — 7.7 ± 5.6 years). Basal insulin had been initiated with a once daily injection in 78.5 % of subjects and mainly at breakfast (69.4 %); daily dose of basal insulin alone was 22.6 ± 13.5 IU. Thus, CREDIT baseline data shows that the reallife management of diabetes in Ukraine does not providesatisfactory glycemic control in people with type 2 diabetes, due to the delay of insulin initiation. At the time of insulin initiation HbA1c is much higher than it is recommended by ADA/EASD Consensus Algorithm and Ukrainian Local Guidelines.
EFFECTS OF THE PARENT-CHILD RELATIONSHIPS ON METABOLIC COMPENSATION IN CHILDREN WITH TYPE 1 DIABETES MELLITUS
Authors: Demchenko O. A.
Published: June 2022

The article is dedicated to the study of the types of paternal relation for children with the heavy form of diabetes mellitus and their influences on the level of indemnification of disease. The unfavorable types of perent-child relation, substantially influencing on diabetes mellitus metabolic compensation are selected in a gender aspect, that must be taken into account at realization of the programs of diabetes mellitus types accompaniment.
FEATURES OF THE INFLUENCE OF OMACOR® ON DAILY INDICATORS OF MONITORING BLOOD PRESSURE IN PATIENTS WITH DIABETES MELLITUS TYPE 2 WITH AUTONOMOUS HEART NEUROPATHY
Authors: Sergienko V. O.
Published: June 2022

The estimation of dynamics of indicators of daily monitoring of arterial pressure on a background is carried out appointment of Omakor® in patients with type 2 diabetes mellitus with autonomic cardiac neuropathy. It is established that the use of Omakor® is accompanied by a tendency to normalize the averages values ​​of diastolic blood pressure (DBP), time index of BP hypertension, the index of the area of ​​arterial hypertension of DBP, variability of DBP in day and night hours; observed there is a decrease in the severity of symptoms of autonomic imbalance. Combination of detected effects indicates the feasibility of using Omakor® in the treatment of patients with type 2 diabetes mellitus with autonomic cardiac neuropathy.
EFFICACY OF TESTOSTERONE SYNTHESIS INDUCTOR APPLICATION "TESTAGEN" IN ANDROGENIC DEFICIENCY IN PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS
Authors: Rossikhin V. V. , Hoshchenko Yu. O. , Osipov P. G.
Published: June 2022

36 patients with chronic abacterial prostatitis (IIIA), manifested by symptoms of the lower urinary tract, received conservative therapy (protocol: α1-adrenolytic + rectal candles with a non-steroidal anti-inflammatory agent, . After a month of treatment, there was a marked improvement in uroflowmetric parameters, a decrease in the level of inflammation in the prostate, an increase in the level of total testosterone in the serum.
EFFECT OF THE DRUG "BIOGLOBIN-U" ON SPERMATOGEN AND INCRETORIAL FUNCTION OF RAT INPOSITS
Authors: Malova Nataliya , Brechka Nataliia , Bondarenko Volodymyr , Koreneva Yevheniia , Ivannikova S. V.
Published: June 2022

The state of spermatogenesis and hormonal function of the testes under the use of the drug "Bioglobin-U" under the conditions of the serotonin model of hypogonadism was studied. It is shown that with the use of the drug "Bioglobin-U" in the treatment-and-prophylactic regimen, an increase in the number of sperm and an increase in the time of preservation of their mobility are observed, with the aim of improving the process of spermatogenesis and incretory function of the testes.
EYE AS A PREDICTOR OF CARDIOVASCULAR PATHOLOGY IN PATIENTS WITH DIABETES MELLITUS
Authors: Poltorak V. V. , Kravchun N. A. , Gorshunska Maryana
Published: June 2022

The global prevalence of diabetes mellitus (diabetes) reached 6.6% (285 million patients) in 2010 and is expected to be 7.8% (438 million patients) in 2030. Among patients with coronary heart disease, the incidence of diabetes is higher, than in the population, and the incidence of cardiovascular disease is higher in patients with diabetes. The Cardiovascular Health Study, which included individuals 65 years of age and older, found that the incidence of clinical or subclinical cardiovascular disease was 70% in individuals with normal glucose levels, 77% in people with advanced glucose, and 86% - for people with first-time diagnosed or verified diabetes mellitus