bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional shift with maintained regenerative potential following portal vein ligation
Authors: Kovács Tibor , Máthé Domokos , Fülöp András , Jemnitz Katalin , Bátai-Konczos Attila , Veres Zsuzsanna , Török György , Veres Dániel Sándor , Horváth Ildikó , Szigeti Krisztián , Homolya László , Szijártó Attila
Published: December 2017

Selective portal vein ligation (PVL) allows the two-stage surgical resection of primarily unresectable liver tumours by generating the atrophy and hypertrophy of portally ligated (LL) and non-ligated lobes (NLL), respectively. To evaluate critically important underlying functional alterations, present study characterised in vitro and vivo liver function in male Wistar rats (n = 106; 210–250 g) before, and 24/48/72/168/336 h after PVL. Lobe weights and volumes by magnetic resonance imaging confirmed the atrophy-hypertrophy complex. Proper expression and localization of key liver transporters (Ntcp, Bsep) and tight junction protein ZO-1 in isolated hepatocytes demonstrated constantly present viable and well-polarised cells in both lobes. In vitro taurocholate and bilirubin transport, as well as in vivo immunohistochemical Ntcp and Mrp2 expressions were bilaterally temporarily diminished, whereas LL and NLL structural acinar changes were divergent. In vivo bile and bilirubin-glucuronide excretion mirrored macroscopic changes, whereas serum bilirubin levels remained unaffected. In vivo functional imaging (indocyanine-green clearance test; 99mTc-mebrofenin hepatobiliary scintigraphy; confocal laser endomicroscopy) indicated transitionally reduced global liver uptake and -excretion. While LL functional involution was permanent, NLL uptake and excretory functions recovered excessively. Following PVL, functioning cells remain even in LL. Despite extensive bilateral morpho-functional changes, NLL functional increment restores temporary declined transport functions, emphasising liver functional assessment.
Successful reconstruction of whole mitochondrial genomes from ancient Central America and Mexico
Authors: Morales-Arce Ana Y. , Hofman Courtney A. , Duggan Ana T. , Benfer Adam K. , Katzenberg M. Anne , McCafferty Geoffrey , Warinner Christina
Published: December 2017

The northern and southern peripheries of ancient Mesoamerica are poorly understood. There has been speculation over whether borderland cultures such as Greater Nicoya and Casas Grandes represent Mesoamerican outposts in the Isthmo-Colombian area and the Greater Southwest, respectively. Poor ancient DNA preservation in these regions challenged previous attempts to resolve these questions using conventional genetic techniques. We apply advanced in-solution mitogenome capture and high-throughput sequencing to fourteen dental samples obtained from the Greater Nicoya sites of Jícaro and La Cascabel in northwest Costa Rica (n = 9; A.D. 800–1250) and the Casas Grandes sites of Paquimé and Convento in northwest Mexico (n = 5; A.D. 1200–1450). Full mitogenome reconstruction was successful for three individuals from Jícaro and five individuals from Paquimé and Convento. The three Jícaro individuals belong to haplogroup B2d, a haplogroup found today only among Central American Chibchan-speakers. The five Paquimé and Convento individuals belong to haplogroups C1c1a, C1c5, B2f and B2a which, are found in contemporary populations in North America and Mesoamerica. We report the first successfully reconstructed ancient mitogenomes from Central America, and the first genetic evidence of ancestry affinity of the ancient inhabitants of Greater Nicoya and Casas Grandes with contemporary Isthmo-Columbian and Greater Southwest populations, respectively.
Intraindividual Behavioral Variability Predicts Foraging Outcome in a Beach-dwelling Jumping Spider
Authors: Lichtenstein James L. L. , Chism Gregory T. , Kamath Ambika , Pruitt Jonathan N.
Published: December 2017

Animal personality, defined as consistent differences between individuals in behavior, has been the subject of hundreds if not thousands of papers. However, little work explores the fitness consequences of variation in behavior within individuals, or intraindividual variability (IIV). We probe the effects of behavioral IIV on predator-prey interaction outcomes in beach-dwelling jumping spiders (Terralonus californicus). Prior studies have found that spiders with higher body condition (body mass relative to size) behave more variably. Thus, we hypothesized that jumping spider activity level IIV would relate positively to foraging performance. To address this, we tested for associations between activity IIV, average activity level, and two measures of foraging success in laboratory mesocosms: change in spider mass and the number of prey killed. Activity IIV positively correlated with the mass that spiders gained from prey, but not with the number of prey killed. This suggests that spiders with high IIV consumed a greater proportion of their prey or used less energy. Interestingly, average activity level (personality) predicted neither metric of foraging success, indicating that behavioral IIV can predict metrics of success that personality does not. Therefore, our findings suggest that IIV should be considered alongside personality in studies of predator-prey interactions.
RNA-Seq reveals seven promising candidate genes affecting the proportion of thick egg albumen in layer-type chickens
Authors: Wan Yi , Jin Sihua , Ma Chendong , Wang Zhicheng , Fang Qi , Jiang Runshen
Published: December 2017

Eggs with a much higher proportion of thick albumen are preferred in the layer industry, as they are favoured by consumers. However, the genetic factors affecting the thick egg albumen trait have not been elucidated. Using RNA sequencing, we explored the magnum transcriptome in 9 Rhode Island white layers: four layers with phenotypes of extremely high ratios of thick to thin albumen (high thick albumen, HTA) and five with extremely low ratios (low thick albumen, LTA). A total of 220 genes were differentially expressed, among which 150 genes were up-regulated and 70 were down-regulated in the HTA group compared with the LTA group. Gene Ontology (GO) analysis revealed that the up-regulated genes in HTA were mainly involved in a wide range of regulatory functions. In addition, a large number of these genes were related to glycosphingolipid biosynthesis, focal adhesion, ECM-receptor interactions and cytokine-cytokine receptor interactions. Based on functional analysis, ST3GAL4, FUT4, ITGA2, SDC3, PRLR, CDH4 and GALNT9 were identified as promising candidate genes for thick albumen synthesis and metabolism during egg formation. These results provide new insights into the molecular mechanisms of egg albumen traits and may contribute to future breeding strategies that optimise the proportion of thick egg albumen.
Topological guiding of elastic waves in phononic metamaterials based on 2D pentamode structures
Authors: Guo Yuning , Dekorsy Thomas , Hettich Mike
Published: December 2017

A topological state with protected propagation of elastic waves is achieved by appropriately engineering a phononic metamaterial based on 2D pentamode structures in silicon. Gapless edge states in the designed structure, which are characterized by pseudospin-dependent transport, provide backscattering-immune propagation of the elastic wave along bend paths. The role of the states responsible for forward and backward transfer can be interchanged by design.
RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin
Authors: Swindell William R. , Sarkar Mrinal K. , Liang Yun , Xing Xianying , Baliwag Jaymie , Elder James T. , Johnston Andrew , Ward Nicole L. , Gudjonsson Johann E.
Published: December 2017

Keratinocyte (KC) hyper-proliferation and epidermal thickening are characteristic features of psoriasis lesions, but the specific contributions of KCs to plaque formation are not fully understood. This study used RNA-seq to investigate the transcriptome of primary monolayer KC cultures grown from lesional (PP) and non-lesional (PN) biopsies of psoriasis patients and control subjects (NN). Whole skin biopsies from the same subjects were evaluated concurrently. RNA-seq analysis of whole skin identified a larger number of psoriasis-increased differentially expressed genes (DEGs), but analysis of KC cultures identified more PP- and PN-decreased DEGs. These latter DEG sets overlapped more strongly with genes near loci identified by psoriasis genome-wide association studies and were enriched for genes associated with epidermal differentiation. Consistent with this, the frequency of AP-1 motifs was elevated in regions upstream of PN-KC-decreased DEGs. A subset of these genes belonged to the same co-expression module, mapped to the epidermal differentiation complex, and exhibited differentiation-dependent expression. These findings demonstrate a decreased differentiation gene signature in PP/PN-KCs that had not been identified by pre-genomic studies of patient-derived monolayers. This may reflect intrinsic defects limiting psoriatic KC differentiation capacity, which may contribute to compromised barrier function in normal-appearing uninvolved psoriatic skin.
N6-methyladenine is an epigenetic marker of mammalian early life stress
Authors: Kigar Stacey L. , Chang Liza , Guerrero Candace R. , Sehring Jacqueline R. , Cuarenta Amelia , Parker Laurie L. , Bakshi Vaishali P. , Auger Anthony P.
Published: December 2017

Recent evidence described 6-methyladenine (6 mA) as a novel epigenetic regulator in a variety of multicellular species, including rodents; however, its capacity to influence gene expression in the mammalian brain remains unknown. We examined if 6 mA is present and regulated by early life stress associated with predator odor exposure (POE) within the developing rat amygdala. Our results provide evidence that 6 mA is present in the mammalian brain, is altered within the Htr2a gene promoter by early life stress and biological sex, and increased 6 mA is associated with gene repression. These data suggest that methylation of adenosine within mammalian DNA may be used as an additional epigenetic biomarker for investigating the development of stress-induced neuropathology.
Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation
Authors: Saito Takeshi , Mizukami Hiroki , Umetsu Satoko , Uchida Chiaki , Inaba Wataru , Abe Makoto , Takahashi Kazuhisa , Kudo Kazuhiro , Itabashi Chieko , Yagihashi Soroku , Hakamada Kenichi
Published: December 2017

Prevalence of pancreatic ductal carcinoma (PDC) is nearly twice in patients with diabetes mellitus, but the reason for this close association remains obscure. Recently promoter methylation of E-cadherin1 (CDH1) and CDKN2A genes, encoding E-cadherin and P16 respectively, are invoked in development of PDC. It is still unclear whether diabetes affects such epigenetic changes and malignant behavior in PDC. In this study, we studied whether diabetes influences the clinico-pathological profile and methylation status of CDH1 and CDKN2A genes in patients with PDC. PDC subjects were divided into 3 groups; 59 cases without diabetes (non-DM), 17 cases with short-term diabetes (short-DM)(diabetes duration 3 yrs>) and 33 cases with long-term diabetes (long-DM)(≧3 yrs). Compared to non-DM or short-DM, long-DM was associated with a higher histological grade of malignancy and a higher tumor stage. Promoter methylation of both CDH1 and CDKN2A was encountered more frequently in PDC patients with long-DM than non-DM or short DM. Cases with CDH1 promoter methylation showed reduced E-cadherin expression and worsened survival. We consider that the presence of long-DM has a negative impact on the prognosis of PDC patients which may be relevant to a high frequency of promoter methylation of CDH1.
Electron beam induced removal of PMMA layer used for graphene transfer
Authors: Son B. H. , Kim H. S. , Jeong H. , Park Ji-Yong , Lee Soonil , Ahn Y. H.
Published: December 2017

We demonstrate the development of an effective technique to remove the poly methyl methacrylate (PMMA) layer used for transferring graphene synthesized by a chemical vapor deposition (CVD). This was achieved utilizing electron-beam bombardment and following developing processes, prior to the use of conventional organic solvents. Field-effect transistors were fabricated on the transferred graphene in order to explore their Dirac points and carrier motilities in the ambient condition - the results were then compared with those from the conventional wet chemical treatment. It was found that the Dirac points were located close to the zero gate bias when compared to those from the acetone and the acetic acid treatments. Most significantly, the field-effect mobility reached as high as 6770 cm2/Vs and 7350 cm2/Vs on average for holes and electrons, respectively, which is more than seven times improvement in comparison to conventional acetone treatments for CVD-grown graphene devices.
Analysis of ENSO’s response to unforced variability and anthropogenic forcing using CESM
Authors: Vega-Westhoff Benjamin , Sriver Ryan L.
Published: December 2017

Understanding how the El Niño-Southern Oscillation (ENSO) may change with climate is a major challenge, given the internal variability of the system and relatively short observational record. Here we analyze the effect of coupled internal variability on changes in ENSO under anthropogenic global warming using the Community Earth System Model (CESM). We present results from a ~5000 year control run with constant pre-industrial conditions and a 50-member climate change ensemble experiment, consisting of historical hindcasts (1850–2005) and future projections to 2100 following representative concentration pathway 8.5 (RCP8.5). Given this large single-model ensemble, we are able to use simple statistical analyses to compare the effects of anthropogenic climate change with the effects of natural modulations in ENSO sea surface temperature (SST) metrics, as well as how internal variability may change with global warming. Changes in eastern Pacific ENSO SST metrics due to climate change are secondary to the model’s natural modulations; however, central Pacific ENSO amplitude significantly decreases, to an extent comparable with natural modulations. We also assess the sensitivity of internal variability estimates to ensemble size. The primary role of natural modulations in this ensemble highlights the importance of careful assessment of ocean-atmosphere internal variability in ENSO projections.
Environmental conditions during winter predict age- and sex-specific differences in reproductive success of a trans-Saharan migratory bird
Authors: López-Calderón C. , Hobson K. A. , Marzal A. , Balbontín J. , Reviriego M. , Magallanes S. , García-Longoria L. , de Lope F. , Møller Anders P.
Published: December 2017

Previous studies have linked winter habitat with subsequent breeding phenology and physical condition of migratory birds, but few have found delayed effects of winter habitat on subsequent reproductive success. The aim of this study was to test if African winter habitat is related to subsequent reproductive success of house martins (Delichon urbicum) breeding at a colony in Spain. We measured stable isotope (δ2H, δ13C, δ15N) values from feathers moulted in West Africa and used confirmatory path analysis to test if isotopic values of winter-grown feathers were related to reproductive success through the mediation of breeding phenology and body condition. We conducted separate analyses for males, females and age classes (yearlings vs ≥ 2 years old). Experienced males wintering in habitats of higher rainfall (as inferred from lower feather δ2H values) were in better body condition and produced more offspring during the subsequent breeding season. In contrast, we did not find any effect of winter habitat on reproductive success of young males or females. These findings provide evidence consistent with a complex causal link between winter habitat quality and subsequent breeding success of long-distance migratory songbirds.
Alternating-magnetic-field induced enhancement of diffusivity in Ni-Cr alloys
Authors: Li Chuanjun , He Shengya , Engelhardt Hannes , Zhan Tongjun , Xuan Weidong , Li Xi , Zhong Yunbo , Ren Zhongming , Rettenmayr Markus
Published: December 2017

For applying an alternating magnetic field (AMF) in materials processing it is of high significance to understand the physical mechanisms behind the change in diffusivity in the AMF. In this work, the effect of the AMF on interdiffusion in a Ni-Cr alloy was investigated with a diffusion couple. The interdiffusion coefficient was found to increase with increasing AMF intensity. The faster diffusivity is a consequence of the enhancement of the dislocation density in the diffusion couples that was confirmed by the broadening of X-ray diffraction peaks. The higher dislocation density is attributed to the magnetoplastic effect (MPE). Theoretical considerations on the relation of MPE, dislocation density and diffusivity are in agreement with the experimental results.
The stringent response promotes biofilm dispersal in Pseudomonas putida
Authors: Díaz-Salazar Carlos , Calero Patricia , Espinosa-Portero Rocío , Jiménez-Fernández Alicia , Wirebrand Lisa , Velasco-Domínguez María G. , López-Sánchez Aroa , Shingler Victoria , Govantes Fernando
Published: December 2017

Biofilm dispersal is a genetically programmed response enabling bacterial cells to exit the biofilm in response to particular physiological or environmental conditions. In Pseudomonas putida biofilms, nutrient starvation triggers c-di-GMP hydrolysis by phosphodiesterase BifA, releasing inhibition of protease LapG by the c-di-GMP effector protein LapD, and resulting in proteolysis of the adhesin LapA and the subsequent release of biofilm cells. Here we demonstrate that the stringent response, a ubiquitous bacterial stress response, is accountable for relaying the nutrient stress signal to the biofilm dispersal machinery. Mutants lacking elements of the stringent response – (p)ppGpp sythetases [RelA and SpoT] and/or DksA – were defective in biofilm dispersal. Ectopic (p)ppGpp synthesis restored biofilm dispersal in a ∆relA ∆spoT mutant. In vivo gene expression analysis showed that (p)ppGpp positively regulates transcription of bifA, and negatively regulates transcription of lapA and the lapBC, and lapE operons, encoding a LapA-specific secretion system. Further in vivo and in vitro characterization revealed that the PbifA promoter is dependent on the flagellar σ factor FliA, and positively regulated by ppGpp and DksA. Our results indicate that the stringent response stimulates biofilm dispersal under nutrient limitation by coordinately promoting LapA proteolysis and preventing de novo LapA synthesis and secretion.
Hierarchically structured metal–organic frameworks assembled by hydroxy double salt–template synergy with high space–time yields
Authors: Duan Chongxiong , Li Feier , Li Libo , Zhang Hang , Wang Xiujun , Xiao Jing , Xi Hongxia
Published: December 2017

A simple, green, and versatile method to rapidly synthesize hierarchically structured metal–organic frameworks at room temperature using a cooperative template strategy.
Comment on “On the positional and orientational order of water and methanol around indole: a study on the microscopic origin of solubility” Phys. Chem. Chem. Phys., 2016, 18, 23006
Authors: Graziano Giuseppe
Published: December 2017

Indole solubility is larger in methanol than in water due to lower magnitude of the cavity creation work.
A charge polarization model for the metal-specific activity of superoxide dismutases
Authors: Barwinska-Sendra Anna , Baslé Arnaud , Waldron Kevin J. , Un Sun
Published: December 2017

EPR shows that the angular position of the histidine-171 ligand likely plays an important role in metal-selective activities of Mn/FeSODs.
Tunable electronic and magnetic properties of graphene-like XYBe3 (XY = BN, AlN, SiC, GeC) nanosheets with carrier doping: a first-principles study
Authors: Ding Yi , Wang Yanli
Published: December 2017

Graphyne-like ternary beryllide nanosheets are found to be promising host materials because of their carrier-induced tunable magnetism and half-metallicity.
The Bethe–Salpeter equation in chemistry: relations with TD-DFT, applications and challenges
Authors: Blase Xavier , Duchemin Ivan , Jacquemin Denis
Published: December 2017

We review the Bethe–Salpeter formalism and analyze its performances for the calculation of the excited state properties of molecular systems.
Simple low cost porphyrinic photosensitizers for large scale chemoselective oxidation of sulfides to sulfoxides under green conditions: targeted protonation of porphyrins
Authors: Mojarrad Aida G. , Zakavi Saeed
Published: December 2017

Large scale chemoselective photooxidation of sulfides to sulfoxides in the presence of the diacids ofmeso-tetra(phenyl)porphyrin with different acids is reported.
Beyond nutrient-based food indices: a data mining approach to search for a quantitative holistic index reflecting the degree of food processing and including physicochemical properties
Authors: Fardet Anthony , Lakhssassi Sanaé , Briffaz Aurélien
Published: December 2017

Processing has major impacts on both the structure and composition of food and hence on nutritional value.
Structure, gelation, and antioxidant properties of curcumin-doped casein micelle powder produced by spray-drying
Authors: Khanji Aya N. , Michaux Florentin , Petit Jeremy , Salameh Dominique , Rizk Toufic , Jasniewski Jordane , Banon Sylvie
Published: December 2017

The encapsulation of curcumin in micellar caseins (MCs) and the production of powder were performed by spray-drying.
Retraction: Alterations in lipid metabolism due to a protein-restricted diet in rats during gestation and/or lactation
Authors: Sosa-Larios T. C. , Milliar-Garcia A. , Reyes-Castro L. A. , Morimoto S. , Jaramillo-Flores M. E.
Published: December 2017

Retraction of ‘Alterations in lipid metabolism due to a protein-restricted diet in rats during gestation and/or lactation’ by T. C. Sosa-Larios, et al., Food Funct., 2017, DOI: 10.1039/c7fo01513e.
Bioimaging of the elemental distribution in cocoa beans by means of LA-ICP-TQMS
Authors: Thyssen Georgina M. , Keil Claudia , Wolff Melanie , Sperling Michael , Kadow Daniel , Haase Hajo , Karst Uwe
Published: December 2017

The distribution of several nutritional and toxic elements in cocoa beans is visualized for the first time using LA-ICP-MS.
In vitro evaluation of the enantiomeric R- and S-1,1′-binaphthyl-2,2′-diaminodichlorido–Pt(ii) complexes in human Burkitt lymphoma cells: emphasis on cellular accumulation, cytotoxicity, DNA binding, and ability to induce apoptosis
Authors: Sørensen Belinda H. , Werth Patrick , Lambert Ian H. , Bednarski Patrick J.
Published: December 2017

The aim of this project is to gain insights into the uptake and cellular actions of the enantiomeric R- and S-1,1′-binaphthyl-2,2′-diaminodichlorido–Pt(ii) complexes.
Unravelling 2-aminoquinazolin-4(3H)-one as an organocatalyst for the chemoselective reduction of nitroarenes
Authors: Thakur Maheshwar S. , Nayal Onkar S. , Rana Rohit , Kumar Manoranjan , Sharma Sushila , Kumar Neeraj , Maurya Sushil K.
Published: December 2017

A novel, green and transition metal-free reduction of nitroarenes has been explored. 2-Aminoquinazolin-4(3H)-one and its derivatives have been first time investigated as hydrogen bonding organocatalysts for the activation of hydrazine hydrate to reduce nitroarenes.
Acid–base bifunctional amphiphilic organic nanotubes as a catalyst for one-pot cascade reactions in water
Authors: Xiong Linfeng , Zhang Hui , He Zidong , Wang Tianqi , Xu Yang , Zhou Minghong , Huang Kun
Published: December 2017

A novel acid–base bifunctional amphiphilic organic nanotube is synthesized and used for one-pot deacetalization-Knoevenagel cascade reactions in water.
Graphene oxide is degraded by neutrophils and the degradation products are non-genotoxic
Authors: Mukherjee Sourav P. , Gliga Anda R. , Lazzaretto Beatrice , Brandner Birgit , Fielden Matthew , Vogt Carmen , Newman Leon , Rodrigues Artur F. , Shao Wenting , Fournier Philip M. , Toprak Muhammet S. , Star Alexander , Kostarelos Kostas , Bhattacharya Kunal , Fadeel Bengt
Published: December 2017

Graphene oxide (GO) undergoes neutrophil myeloperoxidase (MPO) dependent degradation and the degradation products are non-genotoxic for human lung cells.
Shape and structural motifs control of MgTi bimetallic nanoparticles using hydrogen and methane as trace impurities
Authors: Krishnan Gopi , de Graaf Sytze , ten Brink Gert H. , Verheijen Marcel A. , Kooi Bart J. , Palasantzas George
Published: December 2017

Gas-phase tuning of different structural motifs and shape of MgTi bimetallic nanoparticles using H2 and CH4 as trace gas impurities.
Mechanisms of the oxygen reduction reaction on B- and/or N-doped carbon nanomaterials with curvature and edge effects
Authors: Zou Xiaolong , Wang Luqing , Yakobson Boris I.
Published: December 2017

The curvature and edge effects on ORR activities of both isolated B/N doped and BN codoped carbon nanomaterials are investigated.
Synthesis of enzyme-responsive phosphoramidate dendrimers for cancer drug delivery
Authors: Zhang Zhen , Zhou Yongcun , Zhou Zhuxian , Piao Ying , Kalva Nagendra , Liu Xiangrui , Tang Jianbin , Shen Youqing
Published: December 2017

Enzyme-responsive phosphoramidate dendrimers were successfully synthesized and their surfaces were modified with zwitterionic groups for cancer drug delivery.
Entry of nanoparticles into cells: the importance of nanoparticle properties
Authors: Zhao Jiacheng , Stenzel Martina H.
Published: December 2017

Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great importance for the design of safe and efficient nanomedicines.
Acid-sensitive poly(β-cyclodextrin)-based multifunctional supramolecular gene vector
Authors: Zhang Yunti , Jiang Qimin , Wojnilowicz Marcin , Pan Shuaijun , Ju Yi , Zhang Wenjie , Liu Jia , Zhuo Renxi , Jiang Xulin
Published: December 2017

Multifunctional host–guest supramolecular PCD-acetal-PGEA/Ad-PEG-FA polyplexes showing FA-targeting and acid-triggered intracellular gene release resulted in good transfection efficiency and low cytotoxicity.
Efficient procedure with new fused pyrimidinone derivatives, Schiff base ligand and its La and Gd complexes by green chemistry
Authors: Aly Hala M. , Taha Rania H. , El-deeb Nehal M. , Alshehri Ali
Published: December 2017

Synthetic strategies were developed for the construction of some newer more potent derivatives of thiobarbituric acid and its Schiff base metal complexes in both bulk and at the nanoscale.
Self-assembled DNA nanomaterials with highly programmed structures and functions
Authors: Li Zhihao , Wang Jie , Li Yingxue , Liu Xinwen , Yuan Quan
Published: December 2017

This review provides an in-depth understanding and introduces recent progress in the design and applications of DNA nanomaterials which possess intriguing structures and functions.
Synthesis of methoxetamine, its metabolites and deuterium labelled analog as analytical standards and their HPLC and chiral capillary electrophoresis separation
Authors: Jurasek B. , Himl M. , Jurok R. , Hajkova K. , Vobinuskova A. , Rezanka P. , Kuchar M.
Published: December 2017

Methoxetamine, a designer drug marketed as a replacement for the dissociative anaesthetic ketamine, has been associated with significant numbers of hospital related intoxications and deaths in Europe.
Lipase immobilised on silica monoliths as continuous-flow microreactors for triglyceride transesterification
Authors: Alotaibi Mohammed , Manayil Jinesh C. , Greenway Gillian M. , Haswell Stephen J. , Kelly Stephen M. , Lee Adam F. , Wilson Karen , Kyriakou Georgios
Published: December 2017

Lipase immobilised on silica monoliths has been prepared and applied as biocatalytic continuous-flow microreactors for the transesterification of tributyrin as a model bio-oil component.
Mass transfer considerations for monitoring catalytic solid–liquid interfaces under operating conditions
Authors: Rodríguez-García Laura , Walker Roland , Spier Eyal , Hungerbühler Konrad , Meemken Fabian
Published: December 2017

A combined computational and experimental approach for optimizing mass transfer in microreactors for operando ATR-IR spectroscopy characterization of catalytic solid–liquid interfaces.
A reduced graphene oxide–NiO composite electrode with a high and stable capacitance
Authors: Sun Xiaoming , Lu Hao , Liu Peng , Rufford Thomas E. , Gaddam Rohit R. , Fan Xin , Zhao X. S.
Published: December 2017

Thermal decomposition of Ni(acac)2 leads to in situ formation of NiO sandwiched between expanded graphite oxide layers, and this material displays good electrocapacitive properties.
A red to blue series of push–pull dyes for NiO based p-DSSCs
Authors: Brisse R. , Praveen C. , Maffeis V. , Bourgeteau T. , Tondelier D. , Berthelot T. , Geffroy B. , Gustavsson T. , Raimundo J. M. , Jousselme B.
Published: December 2017

The strength of the acceptor group of triphenylamine-bithiophene dyes changes their absorption range and photovoltaic properties.
Cobalt hexacyanoferrate supported on Sb-doped SnO2as a non-noble catalyst for oxygen evolution in acidic medium
Authors: Rodríguez-García Bárbara , Reyes-Carmona Álvaro , Jiménez-Morales Ignacio , Blasco-Ahicart Marta , Cavaliere Sara , Dupont Marc , Jones Deborah , Rozière Jacques , Galán-Mascarós José Ramón , Jaouen Frédéric
Published: December 2017

Cobalt hexacyanoferrate on Sb-doped SnO2as a non-noble catalyst for O2evolution in acidic medium.
Advances in in situ and ex situ tar reforming with biochar catalysts for clean energy production
Authors: Shen Yafei , Fu Yuhong
Published: December 2017

Homogeneous and heterogeneous reactions can occur in the process of in situ or ex situ biomass tar reforming with biochar catalysts.
Role of local response in manipulating the elastic properties of disordered solids by bond removal
Authors: Hexner Daniel , Liu Andrea J. , Nagel Sidney R.
Published: December 2017

We explore the range over which the elasticity of disordered spring networks can be manipulated by the removal of selected bonds.
Light and CO2/N2 dual stimuli-responsive wormlike micelles based on a zwitterionic surfactant and an azobenzene surfactant
Authors: Jiang Jianzhong , Xu Qianqian , Wang Guozheng , Cui Zhenggang
Published: December 2017

Light and CO2/N2 dual stimuli-responsive wormlike micelles (WLMs) were prepared with a zwitterionic surfactant and an azobenzene surfactant. In contrast to traditional CO2 responsive WLMs, a fast and reversible CO2-triggered thinning behavior was observed.
A numerical study of droplet dynamic behaviors on a micro-structured surface using a three dimensional color-gradient lattice Boltzmann model
Authors: Cheng Zihao , Ba Yan , Sun Jinju , Wang Chao , Cai Shengchuan , Fu Xiaojin
Published: December 2017

Non-circular droplet contact areas on micro-structured surfaces are simulated using the lattice Boltzmann method.
Improving stability against desolvation and mercury removal performance of Zr(iv)–carboxylate frameworks by using bulky sulfur functions
Authors: He Yonghe , Hou Yun-Long , Wong Yan-Lung , Xiao Ran , Li Mu-Qing , Hao Zhifeng , Huang Jian , Wang Lei , Zeller Matthias , He Jun , Xu Zhengtao
Published: December 2017

Synergism between oxygen and sulfur donors allows highly variable thioether side chains to be built into the matrices of Zr(iv)–carboxylate networks, boosting the functionality and stability of this promising class of porous solids.
Organic-free synthesis and ortho-reaction of monodisperse Ni incorporated CeO2 nanocatalysts
Authors: Wang W. L. , Liu W. Y. , Weng X. L. , Shang Y. , Chen J. J. , Chen Z. G. , Wu Z. B.
Published: December 2017

Homogeneous solid solutions provide ortho-reaction channels that ensure sufficient contact and reaction of adsorbents and might be very beneficial to Langmuir–Hinshelwood type reactions.
Aqueous-solution synthesis of Na3SbS4 solid electrolytes for all-solid-state Na-ion batteries
Authors: Kim Tae Won , Park Kern Ho , Choi Young Eun , Lee Ju Yeon , Jung Yoon Seok
Published: December 2017

Scalable synthesis of highly conductive Na3SbS4via aqueous-solution routes using precursors of Na2S, Sb2S4, and elemental sulfur for all-solid-state Na-ion batteries is successfully demonstrated.
Ultrahigh rate sodium ion storage with nitrogen-doped expanded graphite oxide in ether-based electrolyte
Authors: Hu Mingxiang , Zhou Hongjiang , Gan Xin , Yang Le , Huang Zheng-Hong , Wang Da-Wei , Kang Feiyu , Lv Ruitao
Published: December 2017

Nitrogen-doped graphite oxide can serve as anode material for Na-ion battery with high initial coulombic efficiency and excellent rate properties.
pH-sensitive micelles with charge-reversible property for tumor growth inhibition and anti-metastasis
Authors: Sun Yu , Bao Yuling , Jiang Xue , Tan Songwei , Yin Mingxing , Yang Conglian , Zhou Liping , Zhang Zhiping
Published: December 2017

Biocompatible VE-based micelles with charge-reversible property for PTX delivery demonstrating effective antitumor and anti-metastasis effects.
Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery
Authors: Liu Min , Wu Lei , Shan Wei , Cui Yi , Huang Yuan
Published: December 2017

CRT-modified nanoparticles could effectively avoid the competitive inhibition of endogenous transferrin, and also convert an endogenous substance from foe to friend for active targeting.
Light-triggered C60 release from a graphene/cyclodextrin nanoplatform for the protection of cytotoxicity induced by nitric oxide
Authors: Hu Zhen , Zhang Dayu , Yu Long , Huang Yudong
Published: December 2017

Here we represent a novel strategy to combine C60 with graphene via host–guest chemistry with excellent NO quenching ability.
Correction: Synergistic photodynamic therapeutic effect of indole-3-acetic acid using a pH sensitive nano-carrier based on poly(aspartic acid-graft-imidazole)-poly(ethylene glycol)
Authors: Sim Taehoon , Lim Chaemin , Hoang Ngoc Ha , Kim Jae Eun , Lee Eun Seong , Youn Yu Seok , Oh Kyung Taek
Published: December 2017

Correction for ‘Synergistic photodynamic therapeutic effect of indole-3-acetic acid using a pH sensitive nano-carrier based on poly(aspartic acid-graft-imidazole)-poly(ethylene glycol)’ by Taehoon Sim et al., J. Mater. Chem. B, 2017, 5, 8498–8505.
Low-dimensional materials-based field-effect transistors
Authors: Wang F. F. , Hu X. Y. , Niu X. X. , Xie J. Y. , Chu S. S. , Gong Q. H.
Published: December 2017

The review article summarizes the research on low-dimensional materials-based field-effect transistors, which will help in device downscaling.
Broadband white-light emission with a high color rendering index in a two-dimensional organic–inorganic hybrid perovskite
Authors: Wu Zhenyue , Ji Chengmin , Sun Zhihua , Wang Sasa , Zhao Sangen , Zhang Weichuan , Li Lina , Luo Junhua
Published: December 2017

Broadband white-light emission with an ultrahigh CRI of 93 based on an organic–inorganic hybrid 2D corrugated perovskite.
Tuning of the degree of charge transfer and the electronic properties in organic binary compounds by crystal engineering: a perspective
Authors: Jiang Hui , Hu Peng , Ye Jun , Zhang Keke K. , Long Yi , Hu Wenping , Kloc Christian
Published: December 2017

7,7,8,8-Tetracyanoquinodimethane (TCNQ) and FxTCNQ (x = 1, 2, 4) as acceptors and aromatic hydrocarbons form a variety of compounds in which the degree of charge transfer is tuned by crystal engineering.
A novel high-performance self-powered UV-vis-NIR photodetector based on a CdS nanorod array/reduced graphene oxide film heterojunction and its piezo-phototronic regulation
Authors: Yu Xiang-Xiang , Yin Hong , Li Hai-Xia , Zhao Han , Li Chong , Zhu Ming-Qiang
Published: December 2017

A high-performance self-powered piezo-phototronic effect enhanced broadband photodetector based on a CdS nanorod array/rGO film heterojunction was fabricated facilely by spin-coating.
ALMA view of RX J1131-1231: Sub-kpc CO (2-1) mapping of a molecular disk in a lensed star-forming quasar host galaxy
Authors: Paraficz D. , Rybak M. , McKean J. P. , Vegetti S. , Sluse D. , Courbin F. , Stacey H. R. , Suyu S. H. , Dessauges-Zavadsky M. , Fassnacht C. D. , Koopmans L. V. E.
Published: December 2017

We present ALMA 2-mm continuum and CO (2-1) spectral line imaging of the gravitationally lensed z = 0.654 star-forming/quasar composite RX J1131-1231 at 240–400 mas angular resolution. The continuum emission is found to be compact and coincident with the optical emission, whereas the molecular gas forms a complete Einstein ring, which shows strong differential magnification. The de-lensed source structure is determined on 400-parsec-scales resolution using a Bayesian pixelated visibility-fitting lens modelling technique. The reconstructed molecular gas velocity-field is consistent with a large rotating disk with a major-axis FWHM ~9.4 kpc at an inclination angle of i = 54° and with a maximum rotational velocity of 280 km s−1. From dynamical model fitting we find an enclosed mass within 5 kpc of M(r < 5 kpc) = (1.46 ± 0.31) × 1011 M⊙. The molecular gas distribution is highly structured, with clumps that are co-incident with higher gas velocity dispersion regions (40–50 km s−1) and with the intensity peaks in the optical emission, which are associated with sites of on-going turbulent star-formation. The peak in the CO (2-1) distribution is not co-incident with the AGN, where there is a paucity of molecular gas emission, possibly due to radiative feedback from the central engine. The intrinsic molecular gas luminosity is L′CO = 1.2 ± 0.3 × 1010 K km s−1 pc2 and the inferred gas mass is MH2 = 8.3 ± 3.0 × 1010 M⊙, which given the dynamical mass of the system is consistent with a CO–H2 conversion factor of α = 5.5 ± 2.0 M⊙ (K km s−1 pc2)−1. This suggests that the star-formation efficiency is dependent on the host galaxy morphology as opposed to the nature of the AGN. The far-infrared continuum spectral energy distribution shows evidence for heated dust, equivalent to an obscured star-formation rate of SFR = 69−25+41 × (7.3/μIR) M⊙ yr−1, which demonstrates the composite star-forming and AGN nature of this system.
A De Novo Xp11.23 Duplication in a Girl with a Severe Phenotype: Expanding the Clinical Spectrum
Authors: Arican Pinar , Cavusoglu Dilek , Gencpinar Pinar , Ozyilmaz Berk , Ozdemir Taha , Dundar Nihal
Published: December 2017

The Xp11.22–p11.23 duplication syndrome was described in 2009 by Giorda et al and is characterized by intellectual disability, speech delay, and electroencephalography anomalies. We report a case of a 23-month-old girl who presented with epilepsy and global developmental delay and who had a small duplication at Xp11.23. The case we present here is the first case showing the clinical features of Xp11.22–p11.23 duplication syndrome only involving synovial sarcoma, X breakpoint (SSX) genes: SSX1, SSX3, SSX4, and SSX9. This case report contributes to an expanding clinical spectrum of Xp11.22–p11.23 duplication syndrome.
Pen Cap Aspirations: Maneuvering for Successful Extraction
Authors: Rao Suhith , Mahajan Jai
Published: December 2017

Aim of this study was to analyze the therapeutic approach with enhanced success of bronchoscopy. We retrospectively analyzed the results of bronchoscopic extraction of pen cap aspirations in our unit from 2000 to 2014. Out of 239 bronchoscopies performed for foreign bodies in airways, there were 8 cases of pen cap aspirations. All 8 were males and age ranged from 5 to 11 years. Seven cases had definitive history, while one patient had a history of chronic respiratory ailment. The foreign bodies were lodged in right and left bronchi in four cases each and seven had their open-end toward the proximal airways. Bronchoscopic extraction was successful in seven patients. The maneuver of rotating the optical forceps by 90 degrees so as to align the pen cap with the vocal cords resulted in success in all the cases. One patient underwent thoracotomy and bronchotomy for removal. Pen cap aspirations occur in school-going children. Aligning the optical forceps with vocal cords during extraction avoids the need for tracheostomy or thoracotomy.
Subthalamic Nucleus: Neuroanatomical Review
Authors: Magalhães Marcelo José Silva de , Reis Claudiojanes dos , Sousa Juliana Rabelo da Silva , Marques Victória Souza , Gonçalves Tayná Cardoso , Ribeiro Iara Cristina Vieira , Cardoso Leide Daiana Silveira , Guimarães Victor Caribé Crosland , Marques Frederico Gustavo de Souza , Pereira Sarah Dias
Published: December 2017

Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section. Histologically, it consists of neurons compactly distributed and filled with a large number of blood vessels and sparse myelinated fibers. This review presents an analysis of this anatomical region, considering what is most recent in the literature. Subthalamic neurons are excitatory and use glutamate as the neurotransmitter. In healthy individuals, these neurons are inhibited by nerve cells located in the side globus pallidus. However, if the fibers that make up the afferent circuit are damaged, the neurons become highly excitable, thus causing motor disturbances that can be classified as hyperkinetic, for example ballism and chorea, or hypokinetic, for example Parkinson disease (PD). The advent of deep brain stimulation has given the subthalamic nucleus great visibility. Studies reveal that the stimulation of this nucleus improves the motor symptoms of PD.
A Systematic Review of Mycoplasma and Ureaplasma in Urogynaecology
Authors: Combaz-Söhnchen Nina , Kuhn Annette
Published: December 2017

Mycoplasma species relevant to the urogenital tract include mycoplasma hominis, mycoplasma genitalia and ureaplasma urealyticum. Their occurrence in the context of urogynaecological disease has been demonstrated in urethritis, cystitis and upper renal tract infections. Their role in hyperactive bladder and interstitial cystitis/painful bladder syndrome is controversial. All the above-mentioned microorganisms can occur as commensals or as potential pathogens. In most cases their role in any particular pathology cannot be proven, only presumed. The aim of this systematic review was to summarise current knowledge on the influence of mycoplasma and ureaplasma in urogynaecological pathology and to provide clinical guidance on diagnosis (when and how is pathogen detection indicated?) and treatment. 377 relevant articles were analysed. In summary: a urethral swab for PCR analysis of the three bacteria should be performed in the context of symptomatic sterile leukocyturia, chronic urethritis and suspected hyperactive bladder or interstitial cystitis/painful bladder syndrome. Symptomatic women should be treated strictly according to results of the antibiogram.
Bewegungstherapie der oberen Extremitäten mit einem Roboterball bei Schlaganfallpatienten – Ergebnisse einer randomisierten kontrollierten Crossover-Studie
Authors: Neuendorf Tilo , Zschäbitz Daniel , Nitzsche Nico , Schulz Henry
Published: December 2017

Hintergrund Der Schlaganfall ist für die betroffenen Patienten häufig mit motorischen Einschränkungen der oberen Extremitäten verbunden. Ein Ziel der anschließenden Rehabilitation ist die möglichst selbstständige Bewältigung der vielfältigen Aufgaben des täglichen Lebens. Neue Therapieverfahren nutzen verschiedene Hardwarekomponenten, um digitale Therapieinhalte umzusetzen. Diese können eine sinnvolle Ergänzung zu etablierten Standardverfahren darstellen.

Ziel der Arbeit In dieser Studie soll der Effekt eines innovativen bewegungstherapeutischen Therapiekonzepts mit einem Roboterball auf motorische Parameter bei Schlaganfallpatienten überprüft werden.

Material und Methoden An der Crossover-Studie nahmen 25 Patienten (60,0 ± 10,0 Jahre, 172,5 ± 13,8 cm, 79,5 ± 13,8 kg, 89,8 ± 72,6 Monate post-stroke) teil. Der Interventions- sowie der Kontrollzeitraum umfassten jeweils 12 Wochen. Das Training mit dem Roboterball erfolgte als Ergänzung zur Standardtherapie zweimal pro Woche für jeweils 45 min. Verschiedene spielerische Inhalte wurden mithilfe von einem Tablet und einem Smartphone durchgeführt.

Ergebnisse Die isometrische Greifkraft konnte um 4,5 ± 3,6 kg (p = 0,000) erhöht werden. Die unilaterale Geschicklichkeit im Roundblock-Test verbesserte sich um 7,5 ± 6,3 gültige Versuche (p = 0,000). Die durch den QuickDASH-Fragebogen erhobene subjektive Gesundheitswahrnehmung der Patienten verbesserte sich um 12,4 ± 13,0 Punkte (p = 0,001).

Diskussion Die zusätzliche Therapie mit dem Roboterball konnte die Funktionsfähigkeit der oberen Extremitäten bei chronischen Schlaganfallpatienten verbessern sowie deren subjektive Gesundheitswahrnehmung positiv beeinflussen. Hingegen stagnierte die Leistungsfähigkeit bei alleiniger Standardtherapie. Moderat betroffene Patienten profitierten am stärksten. Sehr stark ausgeprägte motorische oder kognitive Symptomatik führte teilweise zum Dropout. Die Ergebnisse sollten mit größeren Stichproben verifiziert werden.
Comparison of Long and Short High-Intensity Interval Exercise Bouts on Running Performance, Physiological and Perceptual Responses
Authors: Valstad Sverre , von Heimburg Erna , Welde Boye , van den Tillaar Roland
Published: December 2017

This study compared the effects of long (4×4 min) and short intervals (4×8×20 s) of high-intensity interval exercise bouts (HIIT) on running performance, physiological and perceptual responses, and excess postexercise oxygen consumption (EPOC). Twelve healthy college students (8 men, 4 women; mean age=22±2 years) performed long (90–95% of peak heart rate) and short intervals (maximal intensity) of high-intensity training (running on a non-motorized treadmill) with the same total duration on separate days. The total volume of consumed oxygen during recovery was the same in both cases (P=0.21), whereas the short intervals of high-intensity training were performed at a faster mean running velocity (3.5±0.18 vs. 2.95±0.07 m/s) and at a lower RPEbreath compared with the long intervals of high-intensity training. The blood lactate concentration also tended to be lower during the short intervals of high-intensity training, indicating that short-interval training was perceived to be easier than long-interval training, even though the cardiovascular and metabolic responses are similar. Furthermore, EPOC lasted significantly longer (83.4±3.2 vs. 61.3±27.9 min, P=0.016) and tended to be higher (8.02±4.22=vs. 5.70±3.75 L O2, P=0.053) after short intervals than after long intervals of training.