bluuebunny/crossref_metadata_2025 huggingface dataset:
Technical Features of Shin-Katsurazawa Dam to Be Coaxially Raised with Existent Dam and Measures to Solve the Problems Involved
Authors: Sasaki Shun ,   Ikushunbetsu River Dam Construction Office, Sapporo Development and Construction Department, Hokkaido Regional Development Bureau, Ministry of Land, Infrastructure, Transport and Tourism
 91-1 Ikushunbetsu Yamate-cho, Mikasa-shi, Hokkaido 068-2113, Japan, Suzuki Koichiro , Yoshino Atsuhisa , Chouno Seiichi
Published: July 2018

Among the dams managed by Japan’s Ministry of Land, Construction and Transport, Shin-Katsurazawa Dam is the first dam to be renewed by coaxially raising the embankment of an existent dam. Raising the embankment of an existent dam that is in operation involves various problems that are different from the ones involved in constructing a new dam, such as evaluation of the foundation base rock and integration of concrete of the old and new dam bodies. The technical features of Shin-Katsurazawa Dam as a coaxially raised dam and measures taken to solve the various problems involved are presented.
Current and Future Study Topics on Reservoir Sediment Management by Bypass Tunnels
Authors: Kobayashi Sohei ,   Disaster Prevention Research Institute, Kyoto University Gokasho, Uji, Kyoto 611-0011, Japan, Koshiba Takahiro , Sumi Tetsuya
Published: July 2018

Herein, we summarized the current and future study topics of sediment management using bypass tunnels based on the discussions at the Second International Workshop on Sediment Bypass Tunnels (SBTs) at Kyoto in May 2017. Although reservoir sediment management using bypass tunnels has appeared since the beginning of the 20th century in Kobe, the number of SBTs worldwide is still limited. To promote the installation of SBTs as an effective sediment management measure, it is essential to appropriately evaluate their long-term advantages economically and for the restoration of the aquatic ecosystem. An abrasion model has been developed to predict the abrasion rate of tunnels from the volume of sediment transport. Further, methods to monitor sediment transport in tunnels have advanced. With a significant amount of sediment supply by SBTs, the ecosystems in the downstream reaches of dams can be restored within a few years. A precise rainfall and runoff model for predicting the inflow hydrograph and sediment is essential for the efficient operation of dam gates and SBT (e.g., diverting minimum amount of water for sediment transport). Further studies are needed to clarify the suitable grain size for transportation through SBTs in terms of both the mitigation of tunnel abrasion and promotion of the restoration of downstream ecosystems.
Effectiveness of Flexible Dam Operation and Sediment Replenishment at Managawa Dam, Japan
Authors: Matsushima Katsumi , Hyodo Makoto , Shibata Noriyuki , Shimizu Yoshihiro ,   Kuzuryugawa Integrated Dam and Reservoir Group Management Office, Kinki Regional Development Bureau, Ministry of Land, Infrastructure, Transport and Tourism 29-28 Nakano, Ono-city, Fukui 912-0021, Japan,   IDEA Consultants, Inc., Osaka, Japan
Published: July 2018

A field demonstration project on flexible dam operation at the Managawa dam in the Kuzuryu River Basin has been implemented since 2000. The goal is to restore flow and sediment regimes in the Managawa River, which flows along the Ono-city and is located below the dam. Flexible dam operation stores inflow discharge into a reservoir, which generally uses part of the flood control capacity and appropriately discharges the stored water to the river, also known as the “flood pulse,” for restoring dynamic fluvial systems and the resulting ecological processes. In addition, other options have been carried out in combination with flexible dam operation, for example, sediment replenishment since 2003 and channel rehabilitation since 2007. This article reveals the positive impacts and effectiveness of flexible dam operation, sediment replenishment, and channel rehabilitation, and discusses challenges and future prospects toward translating the field demonstration project into dam management on the ground level. First, we classified reach types to identify the impact of various management options, e.g., flexible dam operation, sediment replenishment, and channel rehabilitation. These management options can influence respected reaches. We conducted a macro-scale analysis to understand the relationship between the aforementioned management options and dynamic fluvial systems, addressing changes in gravel riverbed, vegetation, and habitat types (riffles and pools). Second, a micro-scale analysis was conducted to understand the relationship between the management option and changes in attached algae to sediment and macro-invertebrates, etc. The results show the effectiveness of the middle-scale flood pulse to restore dynamic fluvial systems, increase habitat diversity, and sustain ecological processes. Furthermore, we discussed the impacts of such options on the flow and sediment regimes in Managawa River and revealed that flexible dam operation reduces the occurrence of low flow and midscale floods. It was also revealed methods such as sediment replenishment and channel rehabilitation play an important role in increasing the effectiveness of the middle-scale flood pulse and restoring dynamic fluvial systems, even though sediment replenishment is not sufficient to restore sediment regimes (i.e., bring then back to pre-dam conditions).
Environmental Impact Assessment Plan Due to Sediment Sluicing at Dams Along Mimikawa River System
Authors: Yoshimura Takeshi , Shinya Hiroki ,   Civil and Architectural Engineering Division, Kyushu Electric Power Co., Inc.  2-1-82 Watanabe-dori, Chuo-ku, Fukuoka 810-8720, Japan,   Mimikawa Hydro Power Development Office, Kyushu Electric Power Co., Inc., Miyazaki, Japan
Published: July 2018

The 2005 typhoon disasters taught us that the Mimikawa River system in Miyazaki Prefecture had various problems with sediments in the river basin (the riverbed in dam reservoirs rise so much that flooding risk increases, sediments captured at dams granulate the downstream river channel and destabilize the bridge piers in the downstream river channel). In one of the approaches to solve these problems simultaneously, since 2017, sediment sluicing at a series of dams has been operated cooperatively. Using this approach, we can expect that the river will recover its continuity of sediment movement, returning its physical environment and animal habitats to their original states. Based on environmental surveys and numerical analyses of the current conditions, we have predicted the environmental impacts due to sediment sluicing at dams and defined the method to assess them. This paper presents: 1) an overview of sediment sluicing at dams in the Mimikawa River system, 2) the analysis of the river environment prior to operating sediment sluicing at dams, 3) the prediction of the impacts of sediment sluicing at dams in the river environment, 4) the environmental impact assessment after operating sediment sluicing at dams.
Approaches of the JICA-AMED SATREPS Project to Controlling Outbreaks of Yellow Fever and Rift Valley Fever in Kenya
Authors: Inoue Shingo ,   Department of Virology, Institute of Tropical Medicine, Nagasaki University 1-12-4 Sakamoto, Nagasaki City, Nagasaki 852-8523, Japan
Published: July 2018

Nagasaki University has conducted a JICA-AMED SATREPS project entitled “Development of Rapid Diagnostics and the Establishment of an Alert System for Outbreaks of Yellow Fever and Rift Valley Fever in Kenya.” This project, which ran for the 5-year period from January 2012 to January 2017, aimed to tackle yellow fever and Rift Valley fever in Kenya, as the name implies. The project was carried out in conjunction with the Kenya Medical Research Institute (KEMRI) and the Ministry of Health (MOH) of Kenya. The specific aims of this project were (1) the development of new diagnostics, (2) the strengthening of reference laboratories, and (3) the development of a disease outbreak alert system, particularly to control outbreaks of yellow fever (YF) and Rift Valley fever (RVF). The RVF virus IgM-capture ICT kit, “ImmunoLineTM,” and YF virus IgM-capture ELISA, “KemLisaTM,” were developed as new point-of-care tests. A neutralization test for the confirmation of these arbovirus infections was introduced to the central and local reference laboratories. This project also developed a new disease outbreak alert system, “mSOS,” which the MOH of Kenya has extended nationwide by integrating it into the national health information system (DHIS2).
International Joint Research on Antifungal Resistant Fungi: Collaborative Studies with the University of Campinas, Brazil
Authors: Watanabe Akira ,   Medical Mycology Research Center, Chiba University 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan, Kamei Katsuhiko
Published: July 2018

Increasing of detection rate of antifungal-resistant fungi is a serious global concern in public health. As few epidemiological data on resistant fungi in Brazil have been available, we planned an international joint project with the University of Campinas, São Paulo, Brazil to research antifungal-resistant fungi. This project, supported by the SATREPS program of the Japanese government, started in fiscal 2017.
Pengaruh Lama Penggunaan Minyak Goreng Kelapa Sawit terhadap Karakterisasi Trigliserida dan Crude Glycerol
Authors: Febiola Intan , Hanum Galuh Ratmana
Published: July 2018

The price of cooking oil has been increasing every year. Repetaed of using cooking oil will appearance negative impact for healthy and positive impact for biodiesel industry as raw material glycerol. This research aim to knowing the effect of times palm cooking oil for characteristic triglyceride and crude glycerol of pH, flavour, colour, density, and content for daily use. The category of sample is 0 day as control, 4 days as P1, 8 days as P2, 12 days as P3 with experiment laboratory method. The statistic was perfomed by binomial test for flavour, kruskal-wallis test for colour, and one way anova for pH, density, and content. If any treatment effect was continued with post hoc test. The result showed as control; P1; P2; P3 of characteristic triglyceride respectively for pH are 6.67; 6.13; 6.13; 5.88; for flavour is not flavourfull for all type; for colour are yellow; yellow; clear-yellow; brownish-yellow; for density are 0.740; 0.789; 0.747; 0.734; and content are 93.8; 83.9; 80.2; 75.3. whereas characteristic of crude glycerol respectively for pH are 5.92; 6.18; 6.35; 6.28; for flavour is not flavourfull for all type; for colour are yellow; yellow; red-yellow; red; for density are 1.058; 0.961; 1.021; 1.036; and content are 34.4; 46.3; 51.1; 58.4. The result of statistic is times palm cooking oil not influence for pH, but influence significantly for flavour, colour, density, and content.
Hubungan Kadar Cr dalam Air Tambak terhadap Cr Pada Ikan Nila (Oreochromis niloticus), Ikan Bandeng (Chanos chanos) dan Udang Vaname (Litopenaeus vannamei) di Kawasan Jabon Sidoarjo
Authors: Andini Ary , Ainiyah Siti Dzurrotul
Published: July 2018

Disposal of Lapindo mud into Porong river had caused environmental polluted  which might affect water quality and surrounding especially ponds in Jabon Subdistrict, Sidoarjo city. One of hazardous contaminant that harmful to health was chromium (Cr) metal which had carcinogenic effect. The aim of this study was analyzed Cr levels in  ponds water, Nile tilapia (Oreochromis niloticus) flesh, Milkfish (Chanos chanos) flesh, Vaname shrimp  (Litopenaeus vannamei) flesh, and analyzed the correlation of Cr levels ponds water to Cr levels of Nile tilapia, milkfish, Vaname shrimp. Results of study shown that Cr levels of all ponds water sample were <0,0201mg/L which indicated safe to consumed because they were lower than standard of water Cr levels about <0,05 mg/L. Result of Cr levels in Nile tilapia flesh and Milkfish flesh had same Cr levels about <0,0004 mg/kg which indicated safe to consumed because they were lower than standard of Cr levels  fish flesh about <2,5 mg/kg. Shrimp flesh taken from T3 (0,532 mg/kg ) and T5 (0,461 mg/kg) were higher than standard of Cr levels shrimp flesh about 0,4 mg/kg hence need beware to consume. Correlation analyzed of  ponds water Cr levels to  Nile tilapia flesh, Milkfish flesh, Vaname shrimp  flesh Cr levels shown those were not correlation between both of them because P >0,05.
On Longevity of Solid Construction Materials
Authors: Osipov S. N. , Zakharenko A. V. , Pozdnyakov D. A.
Published: July 2018

Reliable forecasting of longevity for solid construction materials, especially for concrete and reinforced concrete is considered as a rather complicated scientific and technical problem which is often described in a great number of research papers. However this problem does not have a reliable analytical solution with the required statistical realization level. The paper contains a brief analysis of modern views pertaining to breakage processes in solid construction materials including concrete and reinforced concrete due to action of force (in particular, on the basis of temporary strength dependence with a static load) and non-force factors comprising as well carbonization and decrease of hydrogen index. Peculiar features concerning strength decrease of construction materials in time due to action of creep processes (plasticity) have been described in the paper. The paper presents two variants for assessment of possible longevity: without initial damage and with available initial defects. According to the first variant distribution of the test specimens of material for longevity corresponds to a lognormal law and in the second variant the distribution follows more complicated law. The paper provides levels of carbonization indices and a hydrogen index when corrosion of steel reinforcement does not occur. The following necessity has been established that is recommended to take into account not only characteristics and specific features in structure of solid construction materials in their strength theory but also statistical regularities because the breakage process represents in itself an integral phenomenon and due to this the final result can change according to random values of available structural defects, test errors and other factors. In this connection probability of their possible combinations has been described with the help of statistical laws. It has been shown that it is desirable to pay due consideration to maximum number of similar factors in order to increase a reliability of probabilistic-statistical methods for calculation of longevity.
Introduction of Norms for Air Exchange in Rooms and Energy Efficiency of Residential Buildings
Authors: Borukhava L. V. , Shybeka A. S.
Published: July 2018

Energy saving policy conducted all over the world and in Belarus, particularly, leads to revision of technical standard and legal acts on thermal protection of buildings. Gradual increase of resistance to heat transfer of enclosing structures reduces transmission heat losses however expenses on infiltration air heating remain unchangeable. Due to this their portion in overall heat balance of residential buildings is gradually increasing: up to thermal rehabilitation of a building the portion constitutes 30 %, after this process the portion is equal to 53 %. In order to find methods for reduction of heat losses the paper considers an origin of the current standard for inlet air which is equal to 3 m³/h per 1 m² of residential area. It has been shown that the given value has been determined on the assumption of air exchange which is required for assimilation of carbon dioxide and residential area standard per one person. The required air exchange can be reduced up to 1.5 m³/(h×m²) due to improvement of population living conditions and increase in provision of residential area. Calculations have also shown that the given reduction makes it possible to enhance energy efficiency class of a building and decrease portion of heat losses on heating inlet air in overall heat balance. The paper has also revealed that rational light location on both sides permits to reduce a specific index of heat energy consumption for heating and ventilation of a residential building. Determination of outlet air consumption for kitchens has been considered simultaneously with determination of inlet air consumption. It has been ascertained that in order to support combustion process and removal of combustion products consumption of outlet air must constitute 10–20 m³/h according to type of gas stove. Due to the fact that windows can not support the proposed and existing air exchanges they must be completed with plenum valves.
Nuevos datos sobre el origen del Lago de la Baña (Sierra de la Cabrera, NO de España) a partir del análisis geomorfológico y sedimentológico
Authors: Santos González Javier , Redondo Vega José María , González Gutiérrez R.B. , Gómez Villa A.
Published: July 2018

Texto resumen.
Los centros de interpretación como motor de desarrollo turístico local, ¿un modelo fracasado? El caso de la provincia de Cádiz
Authors: Arcila Garrido M. , López Sánchez José Antonio
Published: July 2018

Texto resumen.
Geografía de la deuda pública española. Algunas consideraciones espaciales desde la perspectiva política
Authors: Fernández Cela J. C.
Published: July 2018

Texto resumen.
Delito y espacio en ciudades intermedias: afinando un modelo de análisis territorial en Gerona, Tarragona y Lérida
Authors: Fraile Pedro , Bonastra Quim
Published: July 2018

Texto resumen.
Análisis de la accesibilidad en transporte público al Parque Nacional de Garajonay (Isla de la Gomera): propuesta para su corrección
Authors: Hernández Luis José Ángel
Published: July 2018

Texto resumen.
Auge y caída de nuevas naturalezas urbanas: plantas ornamentales y expansión turístico-residencial en Alicante
Authors: Hernández Hernández María , Sauri Pujol David , Morales Gil Alfredo
Published: July 2018

Texto resumen.
Análisis exploratorio de la funcionalidad de las páginas web de los viñedos del Priorat: el caso de las bodegas de la ruta del vino de la Denominación de Origen de Calidad Priorat
Authors: Camprubí R. , Galí N.
Published: July 2018

Texto resumen.
La gestión colectiva de los contratos en origen de temporeros colombianos en la provincia de Lleida
Authors: Gordo Márquez M. , Allepuz Capdevila R. , Márquez Domínguez Juan Antonio , Torres Solé T.
Published: July 2018

Texto resumen.
El agua en Yecla (Murcia): pasado y futuro de un recurso imprescindible para el desarrollo local
Authors: Morales Yago Francisco José
Published: July 2018

Texto resumen.
Estimación de la humedad del suelo a niveles de capacidad de campo y punto de marchitez mediante modelos predictivos a escala regional
Authors: Pérez Cutillas P. , González Barberá G. , Conesa García Carmelo
Published: July 2018

Texto resumen.
Actitudes y comportamientos de los Natusers en los corredores verdes urbanos: retos y oportunidades. Caso de estudio del Parc Fluvial del Túria (España)
Authors: Alonso Monasterio M. , Alonso Monasterio P. , Viñals María José
Published: July 2018

Texto resumen.
Formación de las mujeres, empoderamiento e innovación rural
Authors: Porto Castro A. M. , Villarino Pérez Montserrat , Baylina Ferré Mireia , García Ramón M. Dolors , Salamaña Serra Isabel
Published: July 2018

Texto resumen.
Patrimonio industrial, revitalización económica y compacidad urbana en el Poblenou-22@barcelona ¿Un nuevo modelo Barcelona?
Authors: Dot Jutgla E. , Pallares Barberá Montserrat
Published: July 2018

Texto resumen.
Treatment and Palliation of Symptoms in Patients With Advanced Pulmonary Arterial Hypertension
Authors: Malotte Kasey L. , Weinberg Aaron , Tapson Victor F.
Published: July 2018

Pulmonary arterial hypertension (PAH) is a complex disease in which the illness as well as the associated treatment can be particularly burdensome. Previously considered to be uniformly fatal, PAH treatment and management has improved with an extended survival. However, this can come with symptom burden. Burden can be associated with the disease itself in addition to the treatment aimed at ameliorating these symptoms. This article explores both the use of PAH-directed therapy as well as traditionally supportive treatment strategies for palliation of symptoms in those with PAH. As highlighted in the patient case described throughout this issue, patients are constantly weighing the benefits and burdens of treatment during each step of their journey.
Differential Protein Expression in Shewanella seohaensis Decolorizing Azo Dyes
Authors: de Souza Nadine Ana , Ramaiah Nagappa , Damare Samir , Furtado Bliss , Mohandass Chellandi , Patil Anushka , De Lima Marsha
Published: July 2018

Background:

Microbial remediation is an ecologically safe alternative to controlling environmental pollution caused by toxic aromatic compounds including azo dyes. Marine bacteria show excellent potential as agents of bioremediation. However, a lack of understanding of the entailing mechanisms of microbial degradation often restricts its wide-scale and effective application.

Objective:

To understand the changes in a bacterial proteome profile during azo dye decolorization.

Methods:

In this study, we tested a Gram-negative bacterium, Shewanella seohaensis NIODMS14 isolated from an estuarine environment and grown in three different azo dyes (Reactive Black 5 (RB5), Reactive Green 19 (RG19) and Reactive Red 120 (RR120)). The unlabeled bacterial protein samples extracted during the process of dye decolorization were subject to mass spectrometry. Relative protein quantification was determined by comparing the resultant MS/MS spectra for each protein.

Results:

Maximum dye decolorization of 98.31% for RB5, 91.49% for RG19 and 97.07% for RR120 at a concentration of 100 mg L-1 was observed. The liquid chromatography-mass spectrometry - Quadrupole Time of Flight (LCMS-QToF) analysis revealed that as many as 29 proteins were up-regulated by 7 hours of growth and 17 by 24 hours of growth. Notably, these were common across the decolorized solutions of all three azo dyes. In cultures challenged with the azo dyes, the major class of upregulated proteins was cellular oxidoreductases and an alkyl hydroperoxide reductase (SwissProt ID: A9KY42).

Conclusion:

The findings of this study on the bacterial proteome profiling during the azo dye decolorization process are used to highlight the up-regulation of important proteins that are involved in energy metabolism and oxido-reduction pathways. This has important implications in understanding the mechanism of azo dye decolorization by Shewanella seohaensis.
A Simple and Novel Colorimetric Optimized Assay for Determination of Hydrogen Peroxide Concentration Under Oxidative Stress Conditions
Authors: Masooleh Anahita K. , Ahmadikhah Asadollah
Published: July 2018

Background:

Reactive oxygen species are formed through the electron transfer reactions in
the mitochondria and chloroplasts and rapidly converted to H2O2.Therefore, H2O2 as a more stable
ROS can be considered as an indicator of cellular stress and it can be used in a steady state to monitor
intracellular stress level. In this regard, the increasing use of various nanoparticles, most of which are
associated with biological systems, are essential to be studied for their possible adverse effects. We
measured the concentration of hydrogen peroxide in samples collected before and after the treatment
with silver nanoparticles by a novel method and optimized this method for the living tissue.

Methods:

In this study, we evaluated the endogenous H2O2 production from Pyricularia oryzae tissue
under normal and stress conditions (such as after treatment with nanoparticles) by spectrophotometric
assay. The method used is based on instant reaction of hydrogen peroxide with vanadium pentoxide in
sulfuric acid solution, forming a peroxovanadate complex that has a maximum absorption at 454 nm.
This method was also compared with other methods.

Results:

The results of this method compared with other methods in the same tissue showed that the
method is simple, inexpensive and more efficient, and the complex is stable for several hours and can
be used for a variety of H2O2 concentrations. Also, the detection range of the mentioned method
equals with high-sensitivity methods such as available commercial kits. Furthermore, this method can
also measure higher values of H2O2.

Conclusion:

The optimized methods for measuring the H2O2 concentration with vanadium pentoxide
in sulfuric acid solution by the colorimetric method are simple, efficient, rapid, accurate, cost-effective
and do not have problems of other methods. The measurements using this method in Pyricularia
oryzae under oxidative stress showed that the created oxidative stress caused by the use of silver
nanoparticles increased H2O2 in fungal tissue. H2O2 is the SOD reaction product that is later decomposed
by CAT. This method is able to measure H2O2 in different ranges and under normal and stress
conditions which are indicative of antioxidant defense. Therefore, we recommend it to the researchers
in similar conditions.
Optimized Trace Analysis of Verapamil in Biological Fluids Using Solvent Bar Micro Extraction Technique Coupled with HPLC-UV Detection
Authors: Farazmand Farzaneh , Qomi Mahnaz
Published: July 2018

Introduction:

Verapamil (Verap) is an antidysrhythmic agent and a calcium channel blocker, indicated for angina, hypertension, supraventricular arrhythmias, and migraine.

Objective:

Drug monitoring plays a critical role in patient survival. In order to prevent the onset of drug toxicity, trace levels of this drug should be determined.

Methods:

For this reason, solvent bar microextraction technique coupled with high-performance liquid chromatography was implemented.

Results:

Under optimum condition, verapamil was micro-extracted from a donor solution (pH=11) to an acceptor solution (pH=3.2). It was transferred through n-octanol as the organic solvent, which was impregnated in the pores of the hollow fiber. Salt addition (30%) had the major effect on the efficiency of the method. Interaction of time (65 min), temperature (25°C), and stirring rate (818 rpm) had a significant effect too. It all resulted in a limit of detection and quantification of 15 ng mL-1 and 50 ng mL-1, respectively. The relative standard deviations of analysis were 4.9% within a day (n=3) and 5.7% between days (n=9). The calibration curves represented good linearity for urine and plasma samples with coefficient estimations higher than 0.99 with a linearity range of 50-5000 ng mL-1. The relative standard deviation for intra- (n=3) and inter-(n=9) day was 4.2% and 5.7%, respectively.

Conclusion:

It could be concluded that the application of this method for dose monitoring can be done at hospital and healthcare facilities.
A Smart Green Spectrophotometric Method for Simultaneous Determination of Severely Overlapped Binary Mixtures Using Normalized Spectrum and Isosbestic Point as Resolving Tools
Authors: H. Mohamed Ekram , Hamza Ahmed , Reda Aya , Adel Ola , Atef Sara
Published: July 2018

Background:

The ability of the normalized spectra when used as a divisor and in combination
with isosbestic point to resolve complex binary or ternary mixtures, Candesartan and Hydrochlorthiazide
binary mixture was taken as a model.

Introduction:

A green simple smart and accurate method using ethanol as a solvent namely simultaneous
derivative ratio (SIDD) was applied to prove the power of normalized spectra and isosbestic point as
spectrophotometric resolving tools.

Methods:

In the proposed SIDD method, the zero order spectra of drugs were simply manipulated using
the normalized spectra of CAN as divisor to obtain the ratio and first derivative spectra in two successive
steps. Firstly, the total amplitude at isosbestic point 255.4 nm of the ratio spectra of the mixture
was measured representing the total actual concentration of both drugs in the mixture. Then, the first
derivative of the ratio spectra was obtained to determine Hydrochlorothiazide concentration at 233 nm.
While the concentration of Candesartan was determined subsequently by subtracting the Hydrochlorothiazide
concentration calculated after derivatization from the total concentration of both drugs
obtained at the ratio spectra before the derivatization step.

Results:

The SIDD was successfully applied for simultaneous determination of both drugs in their pure
form or in their binary mixture either in synthetic prepared mixtures or in combined dosage form the
adopted method was validated according to the ICH guidelines and the results were found to be within
the acceptable limits.

Conclusion:

The adopted method highlighted the important role of normalized spectrum when used as a
divisor in addition to the importance of isosbestic point to resolve severely overlapped spectra. All the
measurements were carried using ethanol which is considered one of the greenest solvents making the
method an environmentally friendly one. the adopted method was validated according to the ICH guidelines
and the results were found to be within the acceptable limits.
Security of NoSQL Database Against Intruders
Authors: Ahmad Khaleel , Alam Mohammad Shoaib , Udzir Nur Izura
Published: July 2018

Background:

The evolution of distributed web-based applications and cloud computing has brought about the demand to store a large amount of big data in distributed databases. Such efficient systems offer excessive availability and scalability to users. The new type of database resolves many new challenges especially in large-scale and high concurrency applications which are not present in the relational database. NoSQL refers to non-relational databases that are different from the Relational Database Management System.

Objective:

NoSQL has many features over traditional databases such as high scalability, distributed computing, lower cost, schema flexibility, semi or un-semi structural data and no complex relationship.

Method:

NoSQL databases are “BASE” Systems. The BASE (Basically Available, Soft state, Eventual consistency), formulates the CAP theorem the properties of which are used by BASE System. The distributed computer system cannot guarantee all of the following three properties at the same time that is consistency, availability and partition tolerance.

Results:

As progressively sharp big data is saved in NoSQL databases, it is essential to preserve higher security measures to ensure safe and trusted communication across the network. In this patent, we describe the security of NoSQL database against intruders which is growing rapidly.

Conclusion:

This patent also defines probably the most prominent NoSQL databases and describes their security aspects and problems.
Enhancing Antibacterial Activity by Combination of Chloramphenicol with Constituents from Dracaena cochinchinensis (Lour.) S.C.Chen
Authors: Ruga Ritbey , Chavasiri Warinthorn
Published: July 2018

Background:

Seven compounds were isolated from Dracaena cochinchinensis and elucidated
their structure by NMR spectroscopic analysis and determined the optical rotation for certain
compounds.

Methods:

These compounds were screened for antibacterial activity by using agar well diffusion and determination
of minimum inhibitory concentration (MIC) was conducted by the broth micro-dilution method
using resazurin colorimetric assay. Further investigation on combination effect between each compound
with chloramphenicol was conducted by agar well diffusion method. Among the seven compounds, compound
4 displayed the highest antibacterial activity against P. acnes and S. aureus with the inhibition zone of
17.3 and 16.7 mm, respectively. The MIC value of 1 and 4 against all tested bacteria was 62.5 µM, whereas
those of other compounds were 62.5-250 µM. The combination of 4 and chloramphenicol exhibited the
most synergistic effect against P. acnes with the rate in increasing antibacterial activity of 4 in combination
as 1,250 folds. This compound also enhanced the antibacterial activity of chloramphenicol at 50 µM with an
inhibition zone of 16.3 mm comparing to its activity alone (8.7 mm).

Results & Conclusion:

The results revealed compound 4 displayed the highest antibacterial activity
alone and in combination with chloramphenicol against P. acnes and S. aureus.
Design, Synthesis and Biological Profiling of Novel Phenothiazine Derivatives as Potent Antitubercular Agents
Authors: Singh Sushil K. , Nath Gopal , Kumar Ashok , Sellamuthu Satheesh K.
Published: July 2018

Background:

Neuroleptic phenothiazines have been reported for antitubercular activity, but
the unwanted side effect (antipsychotic activity) restricted their use as antitubercular drugs.

Objective:

The study aimed to carry out development of phenothiazine based antitubercular agents by
modifying/removing the chemical group(s)/ linker(s) of chlorpromazine essential for exerting an
antipsychotic effect.

Methods:

The designed molecules were filtered with a cut-off of docking score < 2.0 Kcal/mol against
dopamine receptors, so that their binding with the receptor would be reduced to produce no/ less antipsychotic
effect. The molecules were then synthesized and screened against M. tuberculosis H37Rv.
They were further screened against a gram-positive (S. aureus) and a gram-negative (E. coli) bacterial
strains to evaluate the spectrum of activity. The ability of the compounds to cross the blood-brain barrier
(BBB) was also analyzed. The compounds were further examined for cytotoxicity (CC50) against
mammalian VERO cells.

Results:

Compounds 14p, 15p and 16p were found to be the most effective against all the strains viz. M.
tuberculosis H37Rv, S. aureus and E. coli with MIC of 1.56µg/ml, 0.98µg/ml and 3.91µg/ml, respectively.
Further, BBB permeability was found to be diminished in comparison to chlorpromazine, which
would ultimately reduce the unwanted antipsychotic activity. They were also found to be free from toxicity
against VERO cells.

Conclusion:

The designed strategy, to enhance the antitubercular activity with concomitant reduction of
dopamine receptor binding and BBB permeability was proved to be fruitful.
Career Outcomes of Dental Hygiene Baccalaureate Education: A Study of Graduates’ Professional Opportunities, Further Education, and Job Satisfaction
Authors: Kanji Zul , Laronde Denise M.
Published: July 2018

There is a paucity of studies on Canadian baccalaureate dental hygienists. As discussions about the entry‐level education required in dental hygiene continue on national and international platforms, examining outcomes of earning a dental hygiene baccalaureate degree is imperative. The aim of this study was to investigate the professional practice behaviors and career outcomes of graduates of the University of British Columbia (UBC), Canada, Bachelor of Dental Science in Dental Hygiene (BDSc) degree program. UBC dental hygiene entry‐to‐practice (ETP) and degree‐completion graduates from 1994 to 2016 were invited to participate in an online survey with closed‐ and open‐ended questions about practice behaviors and outcomes after earning the BDSc degree. Of the 365 BDSc alumni who received the email invitation, 116 responded, for a 32% response rate. The results showed that 45% of respondents worked outside of the traditional private dental practice setting, specifically in education (23%), administration (9%), public health (8%), and research (5%). Of the 77 degree‐completion respondents, 75% reported that the BDSc degree had expanded their career opportunities. A greater proportion of degree‐completion respondents practiced outside of the clinical setting (p<0.01) and had earned a graduate degree (p=0.04) compared with ETP respondents. Over 25% of total respondents had pursued graduate education. In comparison to results from the 2015 Canadian Dental Hygienists Association job market and employment survey, a significantly greater proportion of BDSc graduates practiced collaboratively with non‐dental professionals (2.7 vs. 0.8, p<0.001), earned more than $80,000 annually (47% vs. 23%, p<0.001), and received more employment benefits (4.0 vs. 3.5, p<0.001). These results highlight the positive impact of baccalaureate education on dental hygiene practice behaviors and career outcomes.
Value of the Manual Dexterity Test as a Screening Tool for Dental School Admissions
Authors: Cleghorn Blaine Murray , Brillant Martha , Kraglund Ferne , Seth Sachin , Garland H. Wayne
Published: July 2018

The Manual Dexterity Test (MDT) was originally developed in the 1940s as part of the American Dental Association's Dental Aptitude Test to assist in reducing high attrition rates in U.S. dental schools. The Perceptual Motor Ability Test (PMAT) replaced the MDT in 1972 in the U.S., but the MDT continues to be available in Canada. The MDT was originally developed to be used as a screening tool to eliminate those applicants who demonstrated poor psychomotor skills, and it was very effective in doing so. The MDT has been subsequently criticized for not being an effective predictor of performance in dental school. The aim of this study was to determine the level of correlation between MDT scores and psychomotor skills assessment scores in preclinical psychomotor skills courses in the DDS program at Dalhousie University. Three key preclinical psychomotor skills courses were identified, and their course coordinators were asked to identify students who had been accepted into the program but had extremely weak psychomotor skills. Those students’ psychomotor skills scores were then compared to their MDT scores. The results showed that when the student had an MDT score of 10 or less, there was high sensitivity (though low specificity) in identifying students with extremely weak psychomotor skills. Those students with MDT scores of 11 or above were unlikely to have difficulties in psychomotor skills courses. These findings support the MDT's use as a screening tool in the admissions process and a minimum cut‐off score of 11 out of 30.
Mobile-Based Oral Chemotherapy Adherence–Enhancing Interventions: Scoping Review (Preprint)
Authors: Skrabal Ross Xiomara , Gunn Kate M , Patterson Pandora , Olver Ian
Published: July 2018

BACKGROUND

Adherence to oral chemotherapy is crucial to maximize treatment outcomes and avoid health complications in cancer patients. Mobile phones are widely available worldwide, and evidence that this technology can be successfully employed to increase medication adherence for the treatment of other chronic diseases (eg, diabetes) is well established. However, the extent to which there is evidence that mobile phone–based interventions improve adherence to oral chemotherapy is unknown.

OBJECTIVE

This scoping review aims to explore what is known about mobile phone–delivered interventions designed to enhance adherence to oral chemotherapy, to examine the reported findings on the utility of these interventions in increasing oral chemotherapy adherence, and to identify opportunities for development of future interventions.

METHODS

This study followed Arksey and O’Malley’s scoping review methodological framework.

RESULTS

The review search yielded 5 studies reporting on 4 interventions with adults (aged >18 years) diagnosed with diverse cancer types. All interventions were considered acceptable, useful, and feasible. The following themes were evident: text messages and mobile apps were the main methods of delivering these interventions, the 2 most commonly employed oral chemotherapy adherence–enhancing strategies were management and reporting of drug-related symptoms and reminders to take medication, the importance of stakeholders’ engagement in intervention design, and the overall positive perceptions of delivery features. Areas for future research identified by this review include the need for further studies to evaluate the impact of mobile phone–delivered interventions on adherence to oral chemotherapy as well as the relevance for future studies to incorporate design frameworks and economic evaluations and to explore the moderator effect of high anxiety, poor baseline adherence, and longer time taking prescribed drug on adherence to oral chemotherapy.

CONCLUSIONS

Despite the increasing body of evidence on the use of mobile phones to deliver medication adherence–enhancing interventions in chronic diseases, literature on the oral chemotherapy context is lacking. This review showed that existing interventions are highly acceptable and useful to cancer patients. The engagement of stakeholders as well as the use of a design framework are important elements in the development of mobile phone–delivered interventions that can be translated into oncology settings.
FAKTOR FAKTOR YANG MEMPENGARUHI KINERJA PERANGKAT NAGARI
Authors: Mardika Nanda Harry
Published: July 2018

The Purposes of this Research aim to determine the effect of the Leadership Style, Work Motivation and Training in partially and simultaneously to the Employee Performance at Airpura District in Pesisir Selatan Regency. Metodhology of this research was used quantitative descriptive methods and multiple linear regression analysis wich used SPSS version 20.0. By using 50 samples, the result showed that Leadership Style, Work Motivation and Training partially and simultaneously have a positive and significant influencing to the Employee Performance at Airpura District in Pesisir Selatan Regency. The regression equation for these three variables is Ŷ = 8.126 + 0, 301 X1 + 0,334X2.+ 0, 180X3. The magnitude effect of three independent variables as together to the dependent variable is 62,4 % and 37,6 % is influenced by other variables which are not examined in this study.
PROFESSIONAL ATTRIBUTES OF INTERNAL AUDITORS IN RIAU
Authors: Nanda Satria Tri
Published: July 2018

This research aims to identify the factors influencing the audit quality of auditors at Inspektorat Provinsi Riau. The population in this research were auditor, examiner, assistant examiner, and P2UPD (Pengawas Penyelenggara Urusan Pemerintah di Daerah) in charge at the Inspectorate in Riau Province and all Inspectorates in Districts and Cities in Riau Province. A total of 290 set of questionnaire were sent and a number of 184 of questionnaires were processed. Using regression analysis conducted by SPSS, the hypotheses testing analysis results show that experience, responsiveness, professional care, executive involvementt, planning and auditability have significant and positive effect on audit quality. These results indicate that the higher the levels of experience, responsiveness, professional care, executive involvement and auditability of Inspectorate officials, the better the quality of audit performed by the Inspectorate Officials of Riau Province.
PENGARUH LIKUIDITAS, SOLVABILITAS DAN PERPUTARAN MODAL KERJA TERHADAP PROFITABILITAS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Wahyuliza Suci , Dewita Nola
Published: July 2018

This study aims to determine the effect of liquidity, solvency and working capital turnover on profitability at manufacturing companies listed on the Indonesia Stock Exchange. In this study, the sample used as many as 32 companies. The data used in the form of financial statements listed on the Indonesia Stock Exchange. The data analysis technique used multiple linear regression analysis after passing the classical assumption test consisting of normality test, multicollinearity test, autocorrelation test and heteroscedasticity test. The results prove that liquidity has a significant effect on profitability, solvency has no effect on profitability and turnover of working capital has a significant positive effect on profitability. Of the two influential variables, liquidity has a greater impact than the working capital turnover. Simultaneously liquidity, solvency and turnover of working capital have a significant effect on profitability. The value of R2 Adjusted in this study is 0.159 which means that 15.9% profitability can be influenced by liquidity, solvency and working capital turnover. While the remaining 84.1% influenced by other variables.

 

Penelitian ini bertujuan untuk mengetahui pengaruh likuiditas, solvabilitas dan perputaran modal kerja terhadap profitabilitas pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Dalam penelitian ini, sampel yang digunakan sebanyak 32 perusahaan. Data yang digunakan berupa laporan keuangan yang terdaftar di Bursa Efek Indonesia. Teknik analisis data menggunakan analisis regresi linier berganda setelah melewati uji asumsi klasik yang terdiri dari uji normalitas, uji multikolinieritas, uji autokorelasi dan uji heteroskedastisitas. Hasil penelitian membuktikan bahwa likuiditas berpengaruh signifikan terhadap profitabilitas, solvabilitas tidak berpengaruh terhadap profitabilitas dan perputaran modal kerja berpengaruh positif signifikan terhadap profitabilitas. Dari kedua variable yang berpengaruh tersebut, likuiditas mempunyai pengaruh yang lebih besar dibandingkan dengan perputaran modal kerja. Secara simultan likuiditas, solvabilitas dan perputaran modal kerja berpengaruh signifikan terhadap profitabilitas. Nilai R2 Adjusted dalam penelitian ini sebesar 0.159 yang berarti bahwa 15.9%  profitabilitas dapat dipengaruhi oleh likuiditas, solvabilitas dan perputaran modal kerja. Sedangkan sisanya 84.1% dipengaruhi oleh variabel-variabel lain.
ANALISIS SOSIALISASI PAJAK DAN PEMANFAATAN TEKNOLOGI INFORMASI TERHADAP KEPATUHAN PELAPORAN SPT WAJIB PAJAK DI KEPULAUAN RIAU
Authors: Nopiana Puspita Rama , Natalia Erni Yanti
Published: July 2018

This research has purpose to analyze socialization of information technology utilization to taxpayer reporting compliance in Riau Islands either partially or simultaneously. This research method is descriptive with quantitative approach. The population of this study consists of the number of individual taxpayers registered in the Tax Office Pratama Batam, Tanjung Pinang and Bintan Islands Islands in Riau Islands amounting to 322,469 Taxpayers. The sample of the research is taxpayer as much as 298 respondents in Kepualauan Riau area, where the amount of sample of this research is calculated by using slovin formula. The results of the research conducted the test explains that: 1) tax socialization has a positive and significant effect for taxpayers on compliance reporting SPT, 2) utilization of information technology has a positive and significant impact for taxpayers on tax reporting compliance, 3) tax socialization and technology utilization the information simultaneously has a positive and significant influence for the taxpayer on tax reporting compliance, where the contribution of coefficient of determination (Adjusted R²) is 35,9% and the rest 64,1% is influenced by other factors not included in this research model.

 

Penelitian ini memiliki tujuan untuk menganalisis sosialisasi pemanfaatan teknologi informasi terhadap kepatuhan pelaporan SPT Wajib Pajak di Kepulauan Riau baik secara parsial maupun simultan. Metode penelitian ini adalah deskriptif dengan pendekatan kuantitatif. Populasi penelitian ini terdiri dari jumlah Wajib Pajak orang pribadi yang terdaftar di Kantor Pelayanan Pajak Pratama Kota Batam, Kota Tanjung Pinang dan Kabupaten Bintan Kepulauan di Kepulauan Riau yang berjumlah 322.469 Wajib Pajak. Sampel penelitian adalah wajib pajak sebanyak 298 responden di wilayah Kepualauan Riau, dimana jumlah dari sampel penelitian ini dihitung dengan menggunkan rumus slovin.  Hasil penelitian pengujian yang dilakukan menjelaskan bahwa: 1) sosialisasi pajak memiliki pengaruh positif dan signifikan bagi Wajib Pajak terhadap kepatuhan pelaporan SPT, 2) pemanfaatan teknologi informasi memiliki pengaruh positif dan signifikan bagi Wajib Pajak terhadap kepatuhan pelaporan SPT, 3) sosialisasi pajak dan pemanfaatan teknologi informasi secara simultan memiliki pengaruh positif dan signifikan bagi Wajib Pajak terhadap kepatuhan pelaporan SPT, dimana kontribusi nilai koefisien determinasi (Adjusted R²) sebesar 35,9% dan sisanya 64,1% dipengaruhi oleh faktor-faktor lainnya yang tidak dimasukan dalam model penelitian ini.