bluuebunny/crossref_metadata_2025 huggingface dataset:
NOVEL ACTIVE SITE INHIBITION OF O-LINKED N-ACETYL GLUCOSAMINE TRANSFERASE (OGT) FROM ALKALOID LIBRARY
Authors: AKINYEMI FLORENCE WUMI , AMEEN OLANREWAJU ADIRU , OSENI TAJUDEEN O. , ALLI ABDULHAMEED OLUWATOMI , ABDULRAHMAN BASHIR DAYO , AHMED ABDULHAKEEM FUNSHO
Published: December 2022

O-linked-N- acetyl glucosaminetransferase (OGT) is an important enzyme which regulates many important cellular processes through posttranscriptional modification of the nuclear and cytosolic proteins. OGT catalyzes the attachment of N- acetylglucosamine portion of uridine diphosphate N- acetyl glucosamine (UDP- GlcNac) to the serine and threonine residues of nuclear and cytoplasmic proteins of multicellular eukaryote in protein O-GlcNacylation process. Hyperglycemia increases GlcNacylation of proteins. GlcNacylation has been linked to some human diseases, such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, and cancer. Several inhibitors of the enzyme have been explored in the treatment of the diseases associated with it. In this study, alkaloids were mined from online database and screened computationally using molecular docking approach. 290 alkaloids were retrieved and docked against OGT, using OGT complexed with a thio – linked substrate as the control, and the docking approach predicted 14-norpseurotinA (14-NSA), Protoveratrine B (PB) and 3-(4-methoxyphenyl)-3-[[2-(4-methoxyphenyl)-1-oxoethyl] amino] propanoic acid (MPOAPA) to be suitable inhibitors of OGT, through their interaction and binding pose with the amino acid residues at the substrate-binding site of the protein, with a  docking score of -11.106, -9.176 and -8.269 respectively. Additionally, the hit compounds were then subjected to ADMETox screening to predict their drug – likeness.  The ADMETox analysis  predicted that 14-NSA, and MPOAPA shows more drug-like characteristics compared to PB and the co crystallised ligand by obeying the rule of five for drug development. However, natural bioactive compounds 14-NSA, and MPOAPA could be a potential active site inhibitor of OGT in the treatment of cancer, diabetes, neurodegenerative diseases and cardiovascular diseases caused by aberrant O- GlcNacylation.
FOUR DIFFERENT STAINING METHODS FOR DETECTION OF MITOTIC FIGURES IN ORAL SQUAMOUS CELL CARCINOMA
Authors: VARMA SIDDHARTHA , ZOPE SAMEER , SURAGIMATH GIRISH , GANGAVATI RASHMI
Published: December 2022

In the diagnosis and prognosis of oral squamous cell carcinoma (OSCC) and oral epithelial dysplasia, evaluation of mitotic figures (MFs) is often performed. Numerous techniques, like microscopy, flow cytometry, nucleotide radio labelling, as well as immuno-histochemistry, have been developed throughout time to evaluate the MFs. The most modern techniques are more precise for everyday usage, but because of time and money constraints, they are less practical. In the current research, mitotic figures in various stages of oral squamous cell carcinoma were examined using Haematoxylin and Eosin stain, Crystal Violet stain, Giemsa stain and Toluidine Blue stain. Based on statistical comparison, the number of mitotic figures seen in each of the four distinct stains was compared.
LOCAL ANAESTHETIC EFFECT OF LIDOCAINE AND ARTICAINE: A COMPARATIVE CLINICAL STUDY
Authors: TIWARY SHIVSAGAR , JOSHI SUBHA , SANYAL PRANOB , KURADE SADEEP
Published: December 2022

Background: Before the invention of anaesthesia, people employed a variety of techniques to lessen pain, such as pressure or ice to numb their limbs. They gave out wine, hemp-marijuana, mandragora, opium, as well as herbal medicines. The only way the Incas could have injected cocaine into a wound was to spit saliva into it, even though they were aware of its topical effects. That would have some impact, but because there wasn't much active cocaine present, the impact wouldn't likely be sufficient to induce anaesthesia. Aim of the study: The aim of this study was to evaluate and compare the anesthestic efficacy of 4% Articaine Hydrochloride with 1:100,000 adrenaline and 2% Lignocaine HCl with 1:80,000 adrenaline in dental extractions.

Methods: In this prospective comparative study 2% Lignocaine HCl with 1:80,000 adrenaline was used as standard solutions.

Results: In this comparative study we assessed the anesthetic efficacy of 4% Articaine HCl with 1:100,000 adrenaline and 2% Lignocaine HCl with 1:80,000 adrenaline for orthodontic premolar extractions.

Conclusion: Through clinical usage, lidocaine hydrochloride has shown effectiveness, low sensitivity, and little toxicity. Research has backed up this medication's efficacy and safety.
“CHANGING WAY OF LEARNING” TERHADAP EFEKTIVITAS PEMBELAJARAN TERBATAS DI ERA PANDEMI COVID-19 PESERTA DIDIK KELAS VII SMPN 2 TAKALAR
Authors: Achmad Muhammad Luthfi , Balkis Syarifa
Published: December 2022

Muhammad Luthfi Achmad, 2022. “Changing Way Of Learning Terhadap Efektivitas Pembelajaran Terbatas Di Era Pandemi Covid-19 Peserta Didik Kelas VII SMPN 2 Takalar. Skripsi, Fakultas Ilmu Sosial dan Hukum Program Studi Ilmu Pengetahuan Sosial Universitas Negeri Makassar. Dibimbing oleh Dalilul Falihin dan Feri Padli. Penelitian ini bertujuan untuk mengetahui 1) Bagaiamana Pengaruh Antara Changing Way Of Learning Terhadap Efektivitas Pembelajaran Terbatas Di Era Pandemi Covid-19 Peserta Didik Kelas VII SMPN 2 Takalar. 2) Apakah Changing Way Of Learning Dapat Meningkatkan Efektivitas Pembelajaran Terbatas Peserta Didik Kelas VII SMPN 2 Takalar. 3) Seberapa Efektif Pembelajaran Terbatas Yang Diterapkan Di Era Pandemi Covid-19 Pada Peserta Didik Kelas VII SMPN 2 Takalar. Metode penelitian yang digunakan adalah metode pendekatan kuantitatif. Teknik pengumpulan data melalui dokumentasi dan kuisioner tertutup. Hasil penelitian diolah dengan menggunakan analisis kuantitatif dengan bantuan aplikasi program windows SPSS. Hasil penelitian ini menunjukkan bahwa : 1) Terdapat hubungan antara variabel Changing Way Of Learning (X) dengan variabel Efektivitas Pembelajaran Terbatas (Y). Hal ini di landaskan pada hasil analisis data yang dilakukan, dimana hasil variabel Changing Way Of Learning memiliki nilai F hitung = 186.322 dengan tingkat signifikansi 0.000 < 0.05. Pada variabel Changing Way Of Learning (X) diketahui R yaitu sebesar 0.761 artinya korelasi/hubungan antara Changing Way Of Learning dengan Efektivitas Pembelajaran Terbatas adalah erat atau kuat sebesar 76,1%. 2) Changing Way Of Learning dapat meningkatkan Efektivitas Pembelajaran Terbatas. Keputusan tersebut dapat dilihat pada nilai koefisien determinasi (R square) 0.580. Dari nilai R square dapat diketahui bahwa Changing Way Of Learning memiliki pengaruh sebesar 58% terhadap Efektivitas Pembelajaran Terbatas, sedangkan sisanya 42% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini. 3) ke-efektifan pembelajaran terbatas yang diterapkan sudah berjalan baik dan sesuai, karena dari 137 peserta didik sebanyak 82 responden dengan persentase 59.9% menyatakan atau mengkategorikan keefektifan pembelajaran terbatas dalam kategori sedang atau bisa dikatakan baik dan sudah sesuai. Kata kunci: Changing Way Of Learning, Efektivitas Pembelajaran Terbatas, Peserta Didik.
PENGARUH SEKOLAH RAMAH ANAK TERHADAP PERILAKU ASOSIAL
Authors: Torro Supriadi , Darmayanti Dyan Paramitha , Nurmagfirah Nurmagfirah
Published: December 2022

This study aims to determine 1) the description of the implementation of child-friendly schools, 2) the effect of child-friendly school programs on ansocial behavior. This type of research is quantitative with a population of 361 people. The research sample was taken using a random sampling technique with a total sample of 41 people. Data collection is done through questionnaires and documentation. Data analysis using descriptive and inferential techniques using SPSS version 24. The results of the study show that the friendly school program has provided space for students to avoid violence at school. This can be seen in the availability of shared reading rooms, open play areas. In addition, the research results also illustrate that variable X (child-friendly school programs) has a significant and very strong influence on variable Y (ansocial behavior). This is indicated by a significance value of 0.002 <0.05, meaning that there is a significant relationship and a coefficient value of 0.838 which indicates a very strong relationship. In addition, for variable X, the tcount value is 1.748. Where the number is > 1.685 then H0 is rejected and H1 is accepted. Programs from child-friendly schools that support extracurricular activities can attract students to actively participate in positive activities carried out by the school. So as to minimize the occurrence of anti-social actions, violence or bullying in the school environment, because students will be preoccupied with activities that simultaneously stimulate high social values.
The smartphone role in the era of information technology
Authors: Alireza Atarodi  , Hamidreza Atarodi
Published: December 2022

The world today is faced with huge achievements in development of technology and this enforce and speed up the process we wish for life. Using technology is a coin with two different sides of positive and may negative that should be cared not to make something worse than it is, then we should be aware of the advantages and disadvantages of the things we use to decrease the possible damages that can be resulted. Smartphone one of the technology era tools can make the best opportunity if it is understood well, mostly by the youth to get the best use of it, however, its properties and capabilities with various functions is beyond the scope of the youth understanding in some parts. The parents, teachers, society and the rulers’ duties should come to view and manage the status with a look toward the future. Neglecting the field, we are talking about something that may result more negative and destructive outcomes for all individual in our planet soon or late, then an effort to manage and or control the problem seems more necessary than ever.
Aktivitas Pembelajaran Bahasa Arab Anak Usia Dini dengan Pendekatan Psikologi Humanistik Carl R. Rogers
Authors: Aziz Abd , Suhada  , Masruri Ahmad
Published: December 2022

Artikel ini bertujuan menjelaskan kesesuaian model pembelajaran bahasa Arab pada usia dini dengan tahapan perkembangan pemerolehan bahasa pada anak dari perspektif psikologi humanistik Carl Rogers. Penelitian ini merupakan studi penelitian literatur, karena data yang dikumpulkan berfokus pada pembelajaran bahasa Arab pada usia dini untuk mengetahui model pembelajaran bahasa Arab anak usia dini melalui perspektif psikologi humanistik Carl Rogers yang menyesuaikan tahapan perkembangan perkembangan bahasa anak. Analisis data dalam penelitian ini menggunakan pendekatan kualitatif deskriptif terhadap pendekatan psikologis Humanistik dari Perspektif Carl Rogers. Artikel ini menyimpulkan bahwa aktivitas pembelajaran bahasa Arab untuk anak usia dini menggunakan pendekatan Carl Rogers, yaitu bahwa orang harus mau belajar dan memiliki kecenderungan untuk belajar sejak lahir, dan ini dapat diterapkan dalam pembelajaran bahasa Arab yang memuat materi kata tunjuk (isim isyarah) melalui buku elektronik Haza dan Haẓihi, sehingga memunculkan daya kreatif tinggi pada diri peserta didik.
Meningkatkan Perkembangan Motorik Halus Anak melalui Media Plastisin
Authors: Fitriani Anis , Hasanah Uswatun , Nopiana
Published: December 2022

Penelitian ini bertujuan untuk meningkatkan perkembangan motorik halus anak melalui media plastisin di TK Aisyiyah Bustanul Athfal Tempuran Trimurjo. Metode penelitian ini merupakan Penelitian Tindakan Kelas (PTK). Penelitian ini dilakukan dengan menggunakan dua siklus dan pada setiap siklusnya dilaksanakan tiga kali pertemuan. Subjek penelitian ini adalah 16 anak TK Aisyiyah Bustanul Athfal Tempuran Trimurjo, yang terdiri dari 9 anak laki-laki dan 7 anak perempuan. Metode pengumpulan data dilakukan melalui observasi dan dokumentasi. Teknik analisis data dilakukan secara kualitatif. Hasil penelitian menunjukkan bahwa media plastisin dapat meningkatkan perkembangan motorik halus anak. Sebelum dilakukan tindakan belum ada anak yang berkembang sangat baik. Setelah adanya tindakan pada siklus I, perkembangan motorik halus anak meningkat sebanyak 4 anak dengan persentase 25%, dan pada siklus II meningkat hingga 11 anak dengan persentase 69% kriteria berkembang sangat baik (BSB). Dalam penggunaan media plastisin, guru mengenalkan cara membentuk plastisin dan mencetak plastisin selanjutnya anak dapat mencoba mempraktekkannya dengan teman-temanya.
Chimeric Antigen Receptor T Cell Therapy For Solid Tumors
Authors: Hsu Jingmei , Yang Yang , Gergis Mia , Bi Xia , Yi Dongni , Gergis Usama
Published: December 2022

Chimeric antigen receptor T (CAR T) cell therapy has revolutionized the management of lymphoid malignancies. However, it is still in its early phase and is facing many obstacles in solid tumors. Therapeutic challenges in solid tumor lead to tumor target diversification and drive new innovations for the improvement of clinical efficacy. This review showcases early clinical works and sheds light on the most notable successes, drawbacks, and strategies employed to allow CAR T therapy to go full speed ahead.
Management of CAR T-cell Related Toxicities
Authors: Murthy Hemant S. , Yassine Farah , Iqbal Madiha , Alotaibi Shaikha , Moustafa Muhamad Alhaj , Kharfan-Dabaja Mohamed A.
Published: December 2022

Chimeric antigen receptor T cell (CAR-T) therapy is an immunotherapy, which represents a therapeutic breakthrough in the treatment of B-cell malignancies and multiple myeloma. Since the first CAR T-cell approval in 2017, there have been five FDA approved CAR-T products, more approved disease indications for CAR-T therapy, and investigational trials launched for other cancers, including solid organ malignancies. CAR-T therapy possesses unique toxicities. Better understanding of these toxicities over time has helped in more efficient diagnosis, management, and treatment strategies. This review will focus on CAR-T-related toxicities including cytokine release syndrome, immune effector cell associated neurotoxicity syndrome (ICANS), cytokine release syndrome (CRS), and hemophagocytic lymphohistiocytosis (HLH)/ macrophage activation syndrome in terms of assessment, grading, and current management strategies. Additionally, this review will cover future directions and research on CAR-T-related toxicities.
Chimeric Antigen Receptor Structure and Manufacturing of Clinical Grade CAR Engineered Cells using Different Bioreactors
Authors: Syed Farhatullah , El Fakih Riad , Alahmari Ali D. , Ali Ahmed S. Osman , Aljurf Mahmoud
Published: December 2022

Increasing success of adaptive cell therapy (ACT), such as genetically engineered T cells to express chimeric antigen receptors (CARs) proven to be highly significant technological advancements and impressive clinical outcomes in selected haematological malignancies, with promising efficacy. The evolution of CAR designs beyond the conventional structures is necessary to address some of the limitations of conventional CAR therapy and to expand the use of CAR T cells to a wider range of malignancies. There are various obstacles with a wide range of engineering strategies in order to improve the safety, efficacy and applicability of this therapeutic modality. Here we describe details of modular CAR structure with all the necessary domains and what is known about proximal CAR signalling in T cells. Furthermore, the global need for adoptive cell therapy is expanding very rapidly, and there is an urgent increasing demand for fully automated manufacturing methods that can produce large scale clinical grade high quality CAR engineered immune cells. Despite the advances in automation for the production of clinical grade CAR engineered cells, the manufacturing process is costly, consistent and involves multiple steps, including selection, activation, transduction, and Ex-Vivo expansion. Among these complex manufacturing phases, the choice of culture system to generate a high number of functional cells needs to be evaluated and optimized. Here we list the most advance fully automated to semi-automated bioreactor platforms can be used for the production of clinical grade CAR engineered cells for clinical trials but are far from being standardized. New processing options are available and a systematic effort seeking automation, standardization and the increase of production scale, would certainly help to bring the costs down and ultimately democratise this personalized therapy. In this review, we describe in detail different CAR engineered T cell platforms available and can be used in future for clinical-grade CAR engineered ATMP production.
Infectious Complications and Preventative Strategies following Chimeric Antigen Receptor T-cells (CAR-T cells) Therapy for B-Cell Malignancies
Authors: Haroon Alfadil , Muhsen Ibrahim N. , Abid Muhammad B. , Albabtain Abdulwahab , Alahmari Ali , Ahmed Syed O. , Fakih Riad E. , Aljurf Mahmoud
Published: December 2022

Several chimeric antigen receptor T-cell constructs (CAR-T cells) are currently approved for the treatment of B-cell malignancies, including non-Hodgkin lymphoma and acute lymphoblastic leukemia. Additionally, multiple other products are being investigated and developed for other hematological malignancies and solid cancers. Patients receiving CAR-T cells are at increased risk of infectious complications that lead to increased morbidity and inferior mortality in these patients. In this review, we discuss the literature on the incidence and types of infection in patients in the early and late-phase after CAR-T cells infusion. Additionally, we summarize the current literature on prophylaxis against viral, bacterial, and fungal infections after CAR-T cells infusion and the utility of preventative and supportive measures including intravenous immunoglobulins and myeloid growth factors.
Perancangan Aplikasi E-Learning Berbasis Web Pada Fakultas Teknik Universitas Pejuang Republik Indonesia
Authors: Baco Syarifuddin , Sukirman  , Indriany Yusuf Dewi
Published: December 2022

Pembelajaran konvensional mengharuskan dosen dan mahasiswa berada dalam satu ruangan diwaktu yang bersamaan untuk melakukan proses belajar mengajar, hal tersebut mengakibatkan mahasiswa yang memiliki kesibukan diluar jam kuliah sering ketinggalan materi. Kendala lain yang sering terjadi adalah apabila dosen yang bersangkutan berhalangan hadir maka proses belajar mengajar tidak dapat terlaksana. Tujuan penelitian ini untuk merancang sistem aplikasi pembelajaran berbasis web guna memberi kemudahan bagi dosen dan mahasiswa dalam proses belajar mengajar. Metode penelitian yang digunakan adalah RAD dimana mengidentifikasi masalah berdasarkan  data yang telah  dikumpulkan, kemudian membuat  design  sistem  aplikasi dan  menerapkan  metode perancangan kedalam database dan coding program. Metode pengujian yang digunakan adalah Black-Box Testing dimana pengujiannya berfokus pada fungsi tampilan dan input/output tanpa mengetahui struktur kode atau program. Hasil pengujian sistem aplikasi ini adalah admin login dan menginput data dosen dan mahasiswa untuk dibuatkan hak akses, setelah dosen dan mahasiswa mendapat hak akses login maka dosen dapat membuat kelas untuk melakukan proses belajar mengajar sedangkan mahasiswa dapat bergabung ke dalam kelas guna mengikuti proses pembelajaran. Kesimpulan dari hasil pengujian sistem aplikasi dapat berjalan baik dan tidak ditemukan bug serta tampilan aplikasi mudah dipahami.
Pengembangan Cerita Interaktif dan Game Edukasi Sejarah Kerajaan Fena Laisela Di Pulau Buru Sebagai Media Pembelajaran Berbasis Android
Authors: Suradi  , Rosmiati  , El Fazza Fahri , Hamzah Indra. R
Published: December 2022

Sejarah atau ilmu sejarah merupakan sebuah ilmu pengetahuan yang memeriksa mengenai cerita atau kisah mengenai insiden masa lampau. Penelitian ini mengacu untuk membuat perancangan cerita interaktif dan game edukasi kerajaan Fena Laisela dengan harapan agar masyarakat dapat lebih mengenal dan mencintai cerita kebudayaan mereka sendiri. Tujuan penelitian dilakukan untuk bagaimana merancang dan membangun aplikasi cerita interaktif dan game edukasi kerajaan Fena Laisela berbasis android dan Menguji aplikasi cerita interaktif dan game edukasi kerajaan Fena Laisela berbasis android. Metode yang digunakan dalam penelitian ini adalah metode pengembangan Perangkat lunak RAD (Rapid Application Development) dimana metode ini berfokus pada pengembangan aplikasi secara cepat, melalui pengulangan dan feedback berulang-ulang. Hasil penelitian ini yaitu aplikasi cerita interaktif dan game edukasi sejarah kerajaan Fena Laisela berbasis android. Fitur - fitur yang dimiliki yaitu video animasi sejarah, game edukasi sejarah, profil tentang aplikasi dan fitur bantuan untuk memudahkan informasi penggunaan aplikasi. Pengujian dan implementasi sistem android ini sesuai dengan hasil yang diharapkan dimana fungsional video animasi dan game edukasi sebagai media pembelajaran tentang sejarah Kerajaan Fena Laisela dapat dirasakan oleh masyarakat.
Sistem Pakar Pendiagnosis Penyakit Pada Budidaya Ikan Lele Menggunakan Metode Forward Chaining
Authors: Baco Syarifuddin , Sajiah  , Dodi  , Kurniawati Desi
Published: December 2022

Pembudidayaan peternak ikan lele memiliki beberapa kendala penyakit berupa bintik putih, gatal, perut kembung, mulut merah dan cacar kulit yang berakibat matinya ikan yang dibudidaya sehingga menurunkan produksi  ikan lele. Tujuan penelitian  ini  merancang  aplikasi  sistem  pakar  pendiagnosis  penyakit  ikan lele menggunakan metode forward chaining agar memudahkan para peternak ikan lele melakukan diagnosa dengan memilih gejala yang dialami ikan lele. Penelitian ini menggunakan metode forward chaining dan metode RAD dimana mengidentifikasi masalah berdasarkan data yang diperoleh dan dilanjutkan dengan mendesain aplikasi sesuai kebutuhan user selanjutnya merancang penyimpanan data serta menginput koding program. Hasil pengujian pengguna mengakses aplikasi sistem pakar dengan cara mengklik tampilan menu konsultasi pada halaman utama lalu memilih gejala-gejala sesuai dialami oleh ikan lele selanjutnya klik tombol diagnosa sehingga sistem akan mendeteksi penyakit berdasarkan aturan yang telah ditetapkan dan cara pencegahan atau solusi pada menu informasi. Kesimpulan aplikasi mudah dipahami karena tampilannya disederhanakan sesuai dengan kebutuhan pengguna.
Rancang Bangun Pendeteksi Jarak Aman Mata Dengan Layar Monitor Televisi Berbasis Arduino Uno
Authors: Putri Husain Nursuci , B Herlinah , Khairah Mithahul , Akbar M
Published: December 2022

Mata adalah indera penglihatan yang berfungsi mempersepsikan bentuk, ukuran, maupun kedudukan suatu objek. Menonton layar televisi dengan jarak 0–119 cm, dapat menyebabkan kerusakan pada mata seperti mata minus, mata juling dan penyempitan pembuluh darah. Paparan dari cahaya televisi akibat menonton terlalu dekat akan berefek pada mata seperti sakit kepala, mata rabun, mata perih, mata kering dan mata berair. Tujuan penelitian merancang bangun pendeteksi jarak aman mata dengan layar monitor televisi berbasis arduino uno guna mencegah menonton layar televisi terlalu dekat yang mengakibatkan kerusakan pada mata. Metode penelitian Research and Development berfungsi menghasilkan, mengembangkan produk tertentu serta menguji keefektifan produk (alat pendeteksi jarak aman mata). Pengujian sistem  yang dilakukan adalah pengujian arduino uno, sensor HY-SRF05, LCD, push button, relay, buzzer. Hasil pengujian alat menggunakan arduino uno terdiri dari dua proses yaitu input proses dan output proses, ketika sensor HY-SRF05 mendeteksi jarak objek mata <120 cm maka relay akan memutuskan tegangan terminal selama 10 detik dan televisi OFF, sebaliknya jika jarak objek mata ≥120 cm relay akan meyambungkan tegangan ke terminal dan televisi ON. Kesimpulan sensor pendeteksi objek pada alat pengatur jarak aman mata beroperasi dengan lancar dan akurat.
Evaluation of integrated nutrient management on soil health, maize productivity and grain quality
Authors: Bal Karanbir kaur , Chhatwal Neeraj
Published: December 2022

Managing various organic residues produced from agricultural waste is today's prominent need. The present experiment was conducted to evaluate the effect of integrated, chemical, and organic fertilizers on maize productivity. Initially, vermicompost was prepared using different organic residues viz., paddy straw, neem leaves and dhaincha leaves, each in combination with cow dung in 1:1 ratio. Further, prepared vermicompost along with integrated nutrient and chemical fertilizer treatments, were tested on maize productivity. The experiment was carried out in Randomized Block Design. The average two-year data revealed the increased yield and yield attributes of maize with integrated nutrient management followed by the recommended dose of fertilizers and different vermicompost treatments. The least maize productivity was noted with control treatment. The different vermicompost treatments comparatively improved the organic carbon (0.43 to 0.45%) and micronutrient status of the soil in the second year of application (Fe- 10.85 to 13.32 mg kg-1, Zn- 2.95 to 4.18 mg kg-1, Cu- 0.55 to 0.73 mg kg-1, Mn- 10.37 to 15.24 mg kg-1). The result of vermicompost application can be recorded higher in terms of improvement in yield and soil properties in the later years, as the initial organic carbon and nutrient content of the experimental soil was recorded to be low, and, it takes almost three to four years for the positive response of soil to the applied organic amendments. Therefore, long-term experiments are required to evaluate the effects of vermicompost on soil chemical properties and maize productivity. The investigation revealed that integrated nutrient treatment proved better in terms of improving the yield and nutrient status of the soil.
ANALISIS KOMPETENSI GURU DALAM MENINGKATKAN HASIL BELAJAR SISWA PADA SEKOLAH MENENGAH PERTAMA NEGERI 2 MUARA BUNGO
Authors: Susanto Joko , Ichsan Muhammad Al , Rahmiati Siti , Chotib M. , Anggraini Zepa
Published: December 2022

Berdasarkan Undang-undang Nomor 14 tahun 2005 pasal 8 tentang Guru dan Dosen bahwa dalam usaha memenuhi mutu pendidikan guru wajib memiliki kualifikasi akademik, kompetensi, sertifikat pendidik, sehat jasmani dan rohani, serta memiliki kemampuan untuk mewujudkan tujuan pendidikan nasional. Tujuan penelitian ini untuk mengetahui bagaiaman, apa hambatan serta upaya kompetensi guru dalam meningkatkan hasil belajar siswa pada Sekolah Menengah Pertama Negeri 2 Muara Bungo. Jenis penelitian yang digunakan dalam penelitian ini adalah deskiptif dengan pendekatan kualitatif. Teknik dalam pengumpulan data penelitian ialah dengan wawancara, observasi, serta dokumentasi dengan jumlah informan sebanyak sepuluh orang. Hasil penelitian menunjukkan bahwa kompetensi guru dalam meningkatkan hasil belajar peserta didik belum cukup baik, hal ini dikarenakan masih ditemukan permasalahan terkait dengan kompetensi pedagogik dan profesional. Hambatan yang ditemukan adalah sebagian tenaga pengajar belum sesuai dengan kebutuhan kurikulum, sebagian guru belum menguasai rencana perangkat pembelajarn dan kekurangan bahan ajar dan sarana guru mengajar. Upaya yang dilakukan adalah dengan melakukan evaluasi kebutuhan tenaga pengajar, membuat aturan dan pengawasan terkait dengan kinerja guru dan memaksimalkan sarana dan prasarana belajar untuk mendukung pemenuhan kompetensi guru dalam meningkatkan hasil belajar peserta didik.
PENGARUH MOTIVASI DAN SELF EFFICACY TERHADAP MINAT BERWIRAUSAHA PADA SISWA/I KELAS XII SMKN 1 BUNGO
Authors: Ulum Panji , Juniarsih Delvita , Wati Vera , Pratiwi Widya , Syukurman M.
Published: December 2022

PENGARUH MOTIVASI DAN SELF EFFICACY TERHADAP MINAT BERWIRAUSAHA PADA SISWA/I KELAS XII SMKN 1 BUNGO
IMPLEMENTASI PERATURAN DAERAH KABUPATEN BUNGO NOMOR 16 TAHUN 2012 TENTANG RETRIBUSI PARKIR DI TEPI JALAN UMUM (Studi pada Dinas Perhubungan Kabupaten Bungo)
Authors: Hidayat Nanang Al , Burhanuddin Burhanuddin , Maros Asra'i
Published: December 2022

Based on the initial observations of researchers in the field, several problems can be identified in the implementation of the Bungo Regency Regional Regulation Number 16 of 2012 concerning Parking Fees on Public Roads, namely the target of receiving fees is not achieved 100%; The determination of the Revenue and Revenue Budget is out of sync between the Revenue Service and the Transportation Service; Limited Human Resources for Transportation in Oversight of Parking Attendant Performance Activities. The purpose of this research is to find out the implementation of Bungo Regency Regional Regulation No. 16 of 2012 concerning Parking Fees on Public Roads. The method chosen in this study is a descriptive method with a qualitative approach. The population in this study were all employees of the transportation service, and people who use parking services in Bungo Regency with a sample of 12 people. The results showed that the Implementation of Bungo Regency Regional Regulation Number 16 of 2012 concerning Parking Fees on Public Roads was seen from 4 main issues, namely parking locations, services, obligations and prohibitions, and rates. The results of the study show that the Bungo Regency Regional Regulation Number 16 of 2012 has not been fully implemented by parking attendants or parking service users themselves.
Implementasi Penebusan Pupuk Bersubsidi Melalui Kartu Tani di Dusun Karak Apung Kecamatan Bathin III Ulu Kabupaten Bungo
Authors: Sari Mela , Nabela Agnia Aska , Astika Yulia Wiji , Wismar Teta
Published: December 2022

Penyaluran pupuk bersubsidi sangat diperlukan bagi para petani di berbagai daerah Indonesia karena mayoritas petani di Indonesia memiliki penghasilan menengah ke bawah dan memerlukan pupuk untuk bertani sementara harga pupuk yang tinggi membuat para petani berfikir untuk membelinya, maka penyaluran pupuk bersubsidi dari pemerintah tersebut sangat berguna bagi para petani karena mereka dapat membeli pupuk dengan harga yang terjangkau dengan kualitas yang baik.?Penelitian ini dilakukan untuk mengetahui bagaimana, dan apa hambatan serta upaya dalam?pelaksanaan?penyaluranpupuk??bersubsidi?di?Dusun Karak Apung?Kecamatan?BathinIII?Ulu?Kabupaten?Bungomenggunakan?kartu?tani.Metode yang digunakan dalam penelitian ini adalah deskriptif dengan pendekatan kualitatif. Populasi dalam penelitian ini adalah?seluruhPemerintahKecamatanBathinIIIUluKabupatenBungo,PenyuluhPertanianKabupaten Bungodan Dinas PertanianKecamatanBathin IIIUlusertaKelompoktanidanMasyarakatKecamatanBathinIIIUluKabupatenBungodengan??teknik purposive samplingdiperoleh sampel berjumlah 10 Orang.?Hasil penelitian ini menunjukan bahwa implementasipenyaluran pupuk bersubsidi di Dusun Karak Apung Kecamatan Bathin III Ulu terlihat belum optimal dikarenakan jumlah dan jenis pupuk yang disalurkan belum mampu mencukupi kebutuhan petani dan juga terdapat salah satu jenis pupuk yang dijual diatas standar harga eceran tertinggi. Hambatannya adalah kuota pupuk bersubsidi yang terbatas, karakteristik sebagian agen penyalur dan ketidaksiapan sebagian petani di Kecamatan Bathin III Ulu. Upaya mengatasi hambatan yang dilakukan adalah mengajukan penambahan kuota dan jenis pupuk bersubsidi, memberikan sanksi tegas kepada agen penyalur dan meningkatkan pengarahan dan bantuan pendaftaran kepada petani.?
PENGARUH KOMPETENSI DAN KOMPENSASI TERHADAP KINERJA KARYAWAN BAGIAN KANTOR PT. PERKEBUNAN NUSANTARA VI UNIT USAHA RIMBO SATU (PERSERO)
Authors: Albadry Syah Amin , Widyastuti Ira , Fatoni Muhammad , Darmawanto Darmawanto
Published: December 2022

Semakin tingi kompetensi dan besar kompensasi yang diterima oleh karyawan, maka semakin tinggi etos kerja karyawan, dan pada akhirnya akan dapat meningkatkan kinerjanya. Sehingga akan berdampa positif bagi suatu perusahaan dengan kelangsungannya. Penelitian ini dilakukan untuk mengetahui bagaimana pengaruh pengaruh kompetensi dan kompensasi terhadap kinerja karyawan tetap PT. Perkebunan? Nusantara? VI? Unit Usaha Rimbo Satu (Persero).Metode yang digunakan dalam penelitian ini adalah asosiatif dengan pendekatan kuntitatif. Populasi dalam penelitian ini adalah karyawan tetap PT. Perkebunan? Nusantara? VI? Unit Usaha Rimbo Satu (Persero) yang kemudian diproses menjadi sampel dengan tekhnik total sampling 44 orang, dimana sampel diambil berdasarkan yang peneliti anggap dapat mewakili permasalahan yang diteliti. Pengumpulan data penelitian ini dilakukan dengan cara menyebarkan angket.Hasil penelitian ini menunjukan bahwa variabel Costumer Review (X1) berpengaruh terhadap variabel Kompetensi (X1) berpengaruh terhadap variabel Kinerja Karyawan (Y), dan Kompensasi (X2) berpengaruh terhadap Kinerja Karyawan (Y), dan Kompetensi (X1) dan Kompensasi (X2) secara simultan berpengaruh terhadap Kinerja Karyawan (Y).Kata Kunci : Kompetensi, Kompensasi, Kinerja, Karyawan
Pengaruh Harga dan Kualitas Layanan Terhadap Pembelian Ulang Konsumen Pada Toko Sumber makmur
Authors: Yasmir Yasmir , Antoni Feri
Published: December 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh harga dan kualitas layanan terhadap pembelian ulang konsumen secara parsial dan simultan terhadap pembelian ulang konsumen toko bangunan Sumber Makmur. Metode penelitian ini menggunakan metode kuantitatif. Sampel penelitian menggunakan teknik sampling accidental. Untuk menghitung jumlah sampel peneliti menggunakan rumus Rao Purba dengan hasil 96,04 dan di bulatkan menjadi 100 responden. Teknik analisis data yang digunakan yaitu analisis analisis deskriptif, uji asumsi klasik, analisis regresi linier berganda, uji t, uji f, uji koefisien determinasi dengan bantuan program SPSS Versi 20.Hasil uji statistik H1 diterima, pengaruh harga terhadap pembelian ulang konsumen thitung > ttabelttabel( 3,585 > 1,98477 ) dengan tingkat signifikansi lebih kecil dari 0,05 (0,01 < 0,05). Hasil uji H2 ditolak, pengaruh kualitas layanan terhadap pembelian ulang konsumen terbukti thitung<ttabel( -0,180 < 1,98477 ) dengan tingkat signifikansi lebih besar dari 0,05 (0,858 > 0,05). Pengaruh secara simultan harga dan kualitas layanan terhadap pembelian ulang konsumen terbukti dengan nilai fhitung> ftabel (14,217> 3,07) dan tingkat signifikansi(0,000 < 0,05) maka H3 diterima.
ANALISIS PELAKSANAAN KERJA SATPOL PP KABUPATEN BUNGO DALAM PENYELENGGARAAN USAHA RUMAH KOS
Authors: Dolly Fajar Ifan , Handayani Asma , Chotib M.
Published: December 2022

Seiring jumlah usaha rumah kos yang ada di wilayah Kelurahan Sungai Kerjan semakin banyak dan belum maksimalnya kegiatan pembinaan dan pengawasan yang dilakukan oleh Satpol PP Kabupaten Bungo, menyebabkan banyaknya terjadi pelanggaran yang dilakukan oleh pemilik maupun penyewa usaha rumah kos. Untuk menyelenggarakan usaha rumah kos yang sesuai dengan norma yang berkembang di tengah-tengah masyarakat, Pemerintah Kabupaten Bungo menetapkan Perda Kabupaten Bungo Nomor 3 Tahun 2019 Tentang Penyelenggaraan Usaha Rumah Kos.Tujuan penelitian ini adalah untuk mengetahui implementasi dan hambatan dalam implementasi pembinaan dan pengawasan dalam penyelenggaraan usaha rumah kos di Kelurahan Sungai Kerjan. Metode yang digunakan deskriptif dengan pendekatan kualitatif. Populasi dalam penelitian ini adalah seluruh anggota Satpol PP Kabupaten Bungo, tim koordinasi dalam penyelenggaraan usaha rumah kos, dan masyarakat Kelurahan Sungai Kerjan. Sampel yang diteliti adalah sebanyak 15 orang yang ditetapkan dengan teknik purposive sampling dan accidental sampling. Analisis yang digunakan adalah model berlangsung/mengalir oleh Miles dan Huberman.Hasil penelitian ini menunjukkan bahwa implementasi pembinaan dan pengawasan dalam penyelenggaraan usaha rumah kos di Kelurahan Sungai Kerjan belum dilaksanakan sesuai aturan, terlihat dari belum ada kegiatan sosialisasi terkait materi Perda oleh Satpol PP Kabupaten Bungo. Namun, kegiatan pemantauan, evaluasi, pemeriksaan langsung dan tanpa pemberitahuan ke kos, sampai kepada penertiban non yustisal telah dilaksanakan oleh Satpol PP Kabupaten Bungo. Hambatan dalam implementasi, yaitu Perda ini ditetapkan bertepatan dengan mewabahnya virus covid-19. Tersebarnya informasi pelaksanaan razia. Keterbatasan Intelijen Satpol PP Kabupaten Bungo
Stylistic analysis of Tivisms in select Nigerian novels
Authors: Aor Terfa
Published: December 2022

The culture of a given people is reflected in their literature and language is a medium through which such a culture is expressed. Stylistic analysis of Tange’s The Legitimate Candidate, Shija’s Whispers of Distant Drums, Gar’s The Blood of the Ram, Kwaghchimin’s A Star of Hope, Tijah’s Slow Men at Work and Norya’s The Luminous Flame resonates with unique expressions which express Tivness. The study investigates the significance of semantic devices in the select novels using Style as a Manner of Expression Model. Methodologically, this study used primary and secondary sources of data. The data for analysis are Tivisms in the select novels. Tivisms refer to Tiv words, expressions, exclamations or interjections, phrases and sentences, unique narrative, dramatic and poetic techniques that are used in literary works talk about Tiv people, culture and language. The study shows that Tivisms serve the following purposes: identity construction, multimodality, beautification, speech flavour and local colour. The paper contributes the literature on language use in Nigerian or African literature.
Environmental chemical risk factors of breast cancer in Nigeria II: Adolescent hormonal contraceptives use
Authors: Olumide Yetunde , Ayanlowo Olusola , Akinkugbe Ayesha , Otrofanowei Erereoghor
Published: December 2022

Globocan’s 2018 cancer statistics show increasing rates of breast cancer in Nigeria. There is sufficient evidence in humans that hormonal contraceptive is a breast cancer risk factor particularly among African American women who begin use before 20 years of age or before first pregnancy. Nigerian breast cancer patients have identical subtypes as African Americans i.e triple negative tumors, early age of onset, clinically aggressive, and poor prognosis. Data from Nigeria show that 37.4% adolescent girls engage in high-risk sexual behaviour. For adolescent girls, dual use of condom and other hormonal contraceptives have been recommended to prevent pregnancy and acquisition of STI/HIV. Adolescents in Nigeria have uncensored access to all the contraceptive mix including hormonal contraceptives. There are also some ethical concerns. There are extremely harmful socio-cultural and socio-economic determinants that promote early sexual debut, Teenage Pregnancy, and Child Marriage. There are also grave health related, social and economic consequences for mother and child, and the community. Both Teenage Pregnancy and Child Marriage undermine nearly every Millennium Development Goal. The notable reason given by some fathers for embracing Child Marriage was to protect daughters from what was perceived as “unwholesome” Western values that permit loss of virginity, pre-marital sex and high adolescent sexual networking, necessitating the use of contraceptives. Hormonal contraceptive is a modifiable risk factor of breast cancer. Appropriate early pre-adolescent and adolescent parental care and nurturing before the crisis stage in godly principles is the gold standard for preventing adolescents’ use of contraceptives. Adolescent pregnancy and Child Marriage are not safe options.
Conversion of sewage sludge from healthcare facility to bio-crude oil using hydrothermal liquefaction technology
Authors: Okareh Oladapo , Akinniyi Ifeoluwa
Published: December 2022

Population growth, municipal waste management challenges, fossil fuel depletion and its associated pollution are increasingly becoming public health issues. These necessitate the production of renewable and sustainable biofuels. This study, therefore, employed the use of hydrothermal liquefaction for the conversion of sewage sludge to bio-crude oil. Samples of the sewage sludge were purposively collected from sewage treatment plant and subjected to laboratory analyses (in triplicates) using standard methods (ASTM and AOAC) to obtain the composition. Sewage sludge (25 kg) from the sewage treatment Plant of University College Hospital, Ibadan, was converted at 300oC to bio-crude oil and biochar using hydrothermal liquefaction. The bio-crude oil was analysed for its physico-chemical properties. Conversion product yield gave 34% bio-crude oil with cloud point, pour point, viscosity and density of -38.89oC, -36.11oC, 0.86cP and 1.04gml-1respectively. The Higher Heating Value (HHV) of the bio-crude oil was 30.60 MJ/kg. A total of 18 compounds were identified from the analysis of Total Petroleum Hydrocarbon (TPH) in the bio-crude oil with 17 compounds within the diesel range organics of crude oil which showed that bio-crude oil has great potential to serve as alternative to fossil fuels.
The Increasing Cross-Talks Between The “Dry” And “Wet” Sciences
Authors: Okonkwo Paul
Published: December 2022

n the early 1960s, the Higher School Certificate Course was the track to direct entrance to Nigerian universities. There was a clear dichotomy between those who opted for Additional Mathematics, Mathematics and Physics and those who followed the “wet sciences” of dissections, buffers, enzymes in Botany, Zoology and Chemistry. The would-be “dry scientists” toted around slide rules, mathematical sets, and pencils and were destined for careers in the computational sciences and engineering. Those in the “dry areas” acted as if they were smarter, and the two groups lived in different scientific worlds. Increasingly, however the two scientific worlds are having serious conversations.
Environmental chemical risk factors of breast cancer in Nigeria IV: Pesticides
Authors: Olumide Yetunde , Ayanlowo Olusola , Akinkugbe Ayesha , Otrofanowei Erereoghor
Published: December 2022

Pesticides are widely used to protect pests in agricultural production and in homes. Women, like men, are heavily involved in Nigerian Agriculture. Since pesticides are essentially poison meant to kill or ward off unwanted living organisms, it is not surprising that they could produce adverse health impacts in people. The pesticides identified as potential breast cancer risk factors discussed in this study are DDT, Lindane, Formaldehyde, Naphthalene/ Mothballs, 2,2-Dichlorovinyl dimethyl phosphate/Aluminium phosphate, Calcium carbide and Diphenylamine. DDT continues to be used against vectors of malaria parasites. Lindane is used by agricultural workers, sprayed in homes by pesticide applicators, used for treating head lice or scabies as shampoos and lotions, and transferred to household members by clothing of workers who are occupationally exposed to Lindane. Formaldehyde is largely released into the air by cosmetics/nail polish, detergents, household furniture, from control of fish parasites and preservation of frozen fish and poultry. The main source of naphthalene is from mothballs sometimes used when storing clothing against moths like Tineola bisselliella. Mothballs are also used as a recreational drug – “Bagging” (sniffing mothballs fumes) particularly among adolescent girls. Dichlorovinyl dimethyl phosphate/Aluminium phosphate are used to protect beans from weevils. Calcium carbide is used as a ripening agent, and Dipheylamine is used as a coating agent on fruit and vegetables to preserve moisture. These chemicals are among the pesticides banned/restricted under the auspices of UNEP but continued to be used in Nigeria because they are cheap. Recommendations are proffered on how to rid pesticides from food.
Environmental chemical risk factors of breast cancer in Nigeria III: Metal: Lead
Authors: Olumide Yetunde , Ayanlowo Olusola , Akinkugbe Ayesha , Otrofanowei Erereoghor
Published: December 2022

Lead (Pb) is a metalloestrogen and a notable breast cancer risk factor. Lead is an International Agency for Research on Cancer (IARC) group 2A carcinogen. There is no level of exposure to lead that is known to be without harmful effects. Nigeria has literally every known environmental risk factor for lead exposure. Notable sources of lead exposure in Nigeria are lead in contaminated water, paints, artisanal gold ore processing, incineration of lead-containing waste and electronic waste (e-waste). Other sources of lead exposure are ‘tiro’—a lead-laden eye cosmetic, smoked fish particularly those displayed near highways with high vehicular traffic density, vegetables and root crops grown in mining communities, fruit exposed to lead-laden ripening agents, “Calabar chalk”—a lead-laden pica mostly consumed by pregnant women, and children’s toys. Prenatal vitamins supplements, paediatric medication syrups, traditional alcoholic and non-alcoholic drinks such as Kunnu and Zobo were also found as notable sources of lead consumption. Studies in Nigeria on blood lead (Pb) levels in children, pregnant women, and breast milk of nursing women were found to contain high lead levels. Lead exposure is preventable. Hitherto, the neurotoxicity of lead has been the dominant concern as regards lead exposure in children. The breast cancer risk factor now reinforces the zero tolerance for lead exposure.
Environmental chemical risk factors of breast cancer in Nigeria I: Broad overview
Authors: Olumide Yetunde , Ayanlowo Olusola , Akinkugbe Ayesha , Otrofanowei Erereoghor
Published: December 2022

Nigeria is currently experiencing a most disturbing level of incidence rate, morbidity and mortality from the ravages of female breast cancer, with its attendant burden of emotional, social and financial consequences. Tens of thousands of chemicals make their way into our everyday products and environment, with little regard for safety. The need to explore the impact of adverse environmental chemical exposures to breast health in Nigeria informed this study as there is need for public health approach to long term prevention. After exploring the robust scientific database on environmental chemical risk factors for female breast cancer, we found that many mammary toxicants are ubiquitous in our environment in Nigeria but have been taken for granted as inevitable in normal life exposures. This study identifies some of the potential environmental chemical risk factors of breast cancer in Nigeria. We describe the special exposure scenarios in Nigeria and prescribe some modest but practical ways to mitigate exposures. The factors that constitute risk to breast cancer could potentially be modified either through community education or government action and regulation. The subject is discussed in multiple Parts before releasing the manuscripts for publication to prevent criminalizing only a few chemicals if discussed and published to the exclusion of others. To our knowledge, this is the first ever comprehensive work on the subject in the African continent and is useful to typical developing countries as are found in sub-Saharan countries and elsewhere since findings and recommendations are usually generic in nature and mutually beneficial.