bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring STEAM teachers’ trust in AI-based educational technologies: a structural equation modelling approach
Authors: Ayanwale Musa Adekunle , Adelana Owolabi Paul , Odufuwa Tolulope Timothy
Published: April 2024

In the rapidly evolving landscape of education, Artificial Intelligence (AI) has emerged as a transformative tool with the potential to revolutionize teaching and learning processes. However, the successful integration of AI in education depends on the trust and acceptance of teachers. This study addresses a significant gap in research by investigating the trust dynamics of 677 in-service Science, Technology, Engineering, Arts, and Mathematics (STEAM) teachers in Nigeria towards AI-based educational technologies. Employing structural equation modelling for data analysis, our findings reveal that anxiety, preferred methods to increase trust, and perceived benefits significantly influence teachers' trust in AI-based edtech. Notably, the lack of human characteristics in AI does not impact trust among STEAM teachers. Additionally, our study reports a significant gender moderation effect on STEAM teachers' trust in AI. These insights are valuable for educational policymakers and stakeholders aiming to create an inclusive, AI-enriched instructional environment. The results underscore the importance of continuous professional development programs for STEAM teachers, emphasizing hands-on experiences to build and sustain confidence in integrating AI tools effectively, thus fostering trust in the transformative potentials of AI in STEAM education.
Dealing with Outliers in Wireless Sensor Networks Localization: An Iterative and Selection-Minimization Strategy
Authors: Mederos-Madrazo Boris , Diaz-Roman Jose , Enriquez-Aguilera Francisco , Cota-Ruiz Juan
Published: April 2024

In recent years, there has been considerable interest in robust range-based Wireless Sensor Network (WSN) localization due to the increasing importance of accurately locating sensors in various WSN applications. However, achieving precise localization is often hampered by the presence of outliers or underestimations in range measurements, particularly when employing the RSS technique. To tackle these issues, we introduce a Two-Step Localization (namely, the SelMin approach). In the initial phase, the approach utilizes Second-Order Cone Programming (SOCP) to minimize distance discrepancies. It does this by comparing a reference Euclidean Distance Matrix (EDM) with a weighted one derived from imprecise distances between sensor nodes. In the subsequent phase, a heuristic method is employed to identify a specific number of imprecise distances, referred to as outliers, that will be disregarded in the first phase, and this two-phase process continues iteratively. The experimental results demonstrate that the SelMin strategy performs better than the DSCL method when evaluated using the Root Mean Square Error (RMSE) metric. This superior performance is maintained even in challenging conditions, such as when there are many outliers (i.e, around 30$$\%$$%) in the network. This indicates that SelMin is a reliable and robust choice for these environments.
Using the conditioned place preference paradigm to assess hunger in dairy calves: Preliminary results and methodological issues
Authors: Lafon Camille , Mendl Michael T , Lecorps Benjamin
Published: April 2024

Dairy calves are typically fed restricted amounts of milk. Although feed restrictions are predicted to result in negative affective states, the relative aversiveness of ‘hunger’ remains largely unexplored in this species. Here, we investigated whether the conditioned place preference paradigm can be used to explore how calves feel when experiencing different levels of satiation. This paradigm provides insight into what animals remember from past experiences, the assumption being that individuals will prefer places associated with more pleasant or less unpleasant experiences. Sixteen Holstein calves were either fed a restricted (3 L per meal totalling 6 L per day) or ‘enhanced’ milk allowance (ad libitum up to 6 L per meal totalling up to 12 L per day) in their home-pen. Calves were then placed in a conditioning pen for 4 h immediately after being fed their morning meal to allow them to develop an association between the pen and their state of post-prandial satiation. Calves were conditioned across four days with their satiation state alternating between days to allow them to develop an association between pen and satiation levels. On the 5th day, calves were individually allowed to roam freely between the two pens for 30 min. We expected that calves would prefer the pen where they previously experienced higher levels of satiation, but our results show no to limited effects of treatment. However, some methodological issues (colour and side bias) prevent us from drawing strong conclusions. We discuss reasons for these issues and potential solutions to avoid these in future studies.
Design and optimization methods towards a 10 kW high beam quality fiber laser based on the counter tandem pumping scheme
Authors: Li Ruixian , Wu Hanshuo , Xiao Hu , Chen Zilun , Leng Jinyong , Huang Liangjin , Pan Zhiyong , Zhou Pu
Published: April 2024

In this study, we investigated the influence of fiber parameters on stimulated Raman scattering (SRS) and identified a unique pattern of SRS evolution in the counter tandem pumping configuration. Our findings revealed that the SRS threshold in counter-pumping is predominantly determined by the length of the output delivery fiber rather than the gain fiber. By employing the counter tandem pumping scheme and optimizing the fiber parameters, a 10 kW fiber laser was achieved with beam quality M2 of 1.92. No mode instability or severe SRS limitation was observed. To our knowledge, this study achieved the highest beam quality in over 10 kW fiber lasers based on conventional double-clad Yb-doped fiber.
The Possibilities of U.S. Imperial History
Authors: Kramer Paul A.
Published: April 2024

It is an honor and pleasure to have my essay discussed by such accomplished and thoughtful colleagues, from whom I continue to learn so much. In setting out to respond to their reflections, I would like to begin by stressing my original essay's tremendous debt to the work of scholars, intellectuals, and political actors who have approached histories of U.S. power in the world from a critical stance, as the piece's long footnotes—about which I have received much good-natured ribbing—were crafted to highlight. Despite occasional efforts to deny or minimize this rich, complicated intellectual history, there is a vibrant, long-standing conversation here—a conversation that is, in fact, my essay's main subject and theme, and without which it simply could not exist.
Spreading primitive groups of diagonal type do not exist
Authors: Bamberg John , Freedman Saul D. , Giudici Michael
Published: April 2024

The synchronization hierarchy of finite permutation groups consists of classes of groups lying between$2$-transitive groups and primitive groups. This includes the class of spreading groups, which are defined in terms of sets and multisets of permuted points, and which are known to be primitive of almost simple, affine or diagonal type. In this paper, we prove that in fact no spreading group of diagonal type exists. As part of our proof, we show that all non-abelian finite simple groups, other than six sporadic groups, have a transitive action in which a proper normal subgroup of a point stabilizer is supplemented by all corresponding two-point stabilizers.
AN UNNOTICED TELESTICH IN VIRGIL, AENEID 8.246–9?
Authors: Silva Gabriel A.F.
Published: April 2024

The aim of this short note is to highlight a possible, hitherto unnoticed, telestich in Verg. Aen. 8.246–9, which presents the Greek word sēma (‘portent’, ‘wonder’, ‘prodigy’, ‘tomb’). To justify this identification, I will argue for its significance from its context in the poem (the battle between Hercules and Cacus), pointing out the insistence on the imagery of light and revelation, and the use of the phrase mirabile dictu, which appears in the same episode of the Aeneid, in the Latin poetic tradition.
Who Publishes Open Access?
Authors: Breuning Marijke , Akyol Seyma
Published: April 2024

Open access (OA) publishing makes scholarship more accessible to readers but also presents additional hurdles for authors. This article examines determinants of OA publishing in well-respected, subscription-based journals. We find that research funding provides the strongest explanation for OA publishing, although various aspects of authorship and an author’s affiliation with a European versus a US institution also matter. We discuss the implications of our findings for publishing in scholarly journals in political science.
Activation of ASL signs during sentence reading for deaf readers: evidence from eye-tracking
Authors: Saunders Emily , Mirault Jonathan , Emmorey Karen
Published: April 2024

Bilinguals activate both of their languages as they process written words, regardless of modality (spoken or signed); these effects have primarily been documented in single word reading paradigms. We used eye-tracking to determine whether deaf bilingual readers (n = 23) activate American Sign Language (ASL) translations as they read English sentences. Sentences contained a target word and one of the two possible prime words: a related prime which shared phonological parameters (location, handshape or movement) with the target when translated into ASL or an unrelated prime. The results revealed that first fixation durations and gaze durations (early processing measures) were shorter when target words were preceded by ASL-related primes, but prime condition did not impact later processing measures (e.g., regressions). Further, less-skilled readers showed a larger ASL co-activation effect. Together, the results indicate that ASL co-activation impacts early lexical access and can facilitate reading, particularly for less-skilled deaf readers.
Historical Soil Moisture Variability in High‐Latitude Humid Regions: Insights From a Paleoclimate Data‐Model Comparison
Authors: Wang Lu , Liu Hongyan , Seftigen Kristina , Chen Deliang , Fang Congxi , Liang Boyi , Yue Yuemin , Wang Kelin
Published: April 2024

Understanding historical soil moisture (SM) variations and their relationship with temperature in high‐latitude humid regions is essential for predicting hot droughts under widespread warming. This paper presents the first‐ever annual‐resolution summer surface SM reconstruction (1736–2006 CE) in Sweden, located in northern Europe (NE). The reconstruction utilizes the paleoclimate proxy, tree‐ring δ18O, which exhibits a strong correlation with reanalysis SM data during 1948–2007 CE (r = −0.67, p < 0.001). In contrast to an unprecedented trend suggested by previous studies, our reconstruction exhibits a wetting trend in NE since the 1960s falling within the historical spectrum of trends. Both reanalysis SM data and our reconstruction show significant negative correlations with temperature at interannual timescales. However, Coupled Model Intercomparison Project Phase 6 climate models failed to capture the significant SM‐temperature relationship during the historical (1850–1947 CE) and observation periods (1948–2006 CE). This proxy‐model comparison represents a critical step toward enhancing our understanding of SM dynamics and the reliability of SM projections in high‐latitude humid regions.
Distribution and Abundance of Solar Wind‐Derived Water in Chang'E‐5 Core Samples and Its Implications
Authors: Tian Heng‐Ci , Hao Jialong , Lin Yangting , Xu Yuchen , Jin Ziliang , Zhang Chi , Yang Wei , Hu Sen , Li Ruiying , Yue Zongyu , Li Qiuli , Wei Yong , Li Xianhua , Wu Fuyuan
Published: April 2024

Knowledge regarding the abundance and distribution of solar wind (SW)‐sourced water (OH/H2O) on the Moon in the shallow subsurface remains limited. Here, we report the NanoSIMS measurements of H abundances and D/H ratios on soil grains from three deepest sections of the Chang'E‐5 drill core sampled at depths of 0.45–0.8 m. High water contents of 0.13–1.3 wt.% are present on approximately half of the grain surfaces (topmost ∼100 nm), comparable to the values of Chang'E‐5 scooped soils. The extremely low δD values (as low as −995‰) and negative correlations between δD and water contents indicate that SW implantation is an important source of water beneath the lunar surface. The results are indicative of homogeneous distribution of SW‐derived water in the vertical direction, providing compelling evidence for the well‐mixed nature of the lunar regolith. Moreover, the findings demonstrate that the shallow subsurface regolith of the Moon contains a considerable amount of water.
Repeated and Long‐Lasting Fault Activation on Amazonian Mars as Demonstrated by Tectonically Induced Landslides
Authors: Woodley S. Z. , Fawdon P. , Balme M. R. , Rothery D. A.
Published: April 2024

We identify and analyze a large shortening structure (surface expression of a thrust fault) in western Arabia Terra, Mars, exhibiting recent, repeated, and long‐lasting tectonic activity. Where the fault system deforms Marsabit crater rim, four landslides with differing degradation states extend onto the crater floor. We propose these were triggered by episodic re‐activation of the thrust system. Using a morphological map and crater size frequency statistics we show that the fault system experienced at least four landslide‐inducing events during the Middle to Late Amazonian. We note that 1.4 km total displacement on the fault plane must have required many events to accumulate if motion was by brittle failure rather than continuous creep. The current understanding of tectonic activity and stress‐sources since 3.6 Ga, cannot account for these repeated and large Amazonian marsquakes—suggesting revaluation of sources of stress to account for a more active and complex Amazonian tectonic history.
Machine Learning Based Modeling of Thermospheric Mass Density
Authors: Pan Qian , Xiong Chao , Lühr Hermann , Smirnov Artem , Huang Yuyang , Xu Chunyu , Yang Xu , Zhou Yunliang , Hu Yang
Published: April 2024

In this study, we propose a machine learning based approach to construct an empirical model of thermospheric mass densities, based on the MultiLayer Perceptron and bi‐directional Long Short‐Term Memory for ensemble learning model (MBiLE). The MBiLE model was trained by using only the thermospheric mass density from Swarm C satellite at ∼450 km altitude. To assess the performance of the MBiLE model, the model predictions were compared with observations from several satellites, namely, the Swarm C, the Challenging Minisatellite Payload (CHAMP) and the Gravity Field and Steady‐State Ocean Circulation Explorer (GOCE) satellites. The determination coefficients (R2) for the three satellites are 0.98, 0.99, and 0.98, respectively. The MBiLE model predicts the thermospheric mass density well not only at Swarm C altitude but also at lower altitudes. Earlier empirical models based on multivariate least‐square‐fitting approach failed to achieve this good altitude generalization (e.g., Liu et al., 2013, https://doi.org/10.1002/jgra.50144; Xiong et al., 2018a, https://doi.org/10.5194/angeo‐2018‐25). Further tests have been made by checking the MBiLE model prediction deviations in relation to magnetic local time, day of year, solar flux level, and magnetic activities. No obvious dependences are found for these parameters. Comparing with the NRLMSIS‐2.0 model, the MBiLE model improves prediction accuracy by 91%, 66%, and 56% at the three satellites altitudes. The results indicate that the MBiLE model has the ability to predict well the thermospheric mass density over a wide altitude range, for example, from 224 to 528 km, offering potential for atmospheric research applications.
Wind‐Driven Seasonal Variability of Deep‐Water Overflow From the Pacific Ocean to the South China Sea
Authors: Chen Lei , Yang Jiayan , Wu Lixin , Lin Xiaopei
Published: April 2024

The South China Sea (SCS) is a semi‐enclosed marginal sea linked to the broader oceans via various geographically constrained channels. Beneath the main thermocline depth, Luzon Strait is the only conduit for water‐mass exchanges. Observations indicate a substantial seasonal variability in the inflow transport of deep water from the Pacific Ocean. This study aims to identify and examine key drivers for such seasonal changes. It is found that seasonal variability of the deep‐water transport into the SCS is primarily driven by surface wind stress. An imbalance in wind‐driven exchanges of surface water between the SCS and external seas demands compensational transports in subsurface layers so that the net volume transport into the SCS is conserved, resulting in seasonal variations in deep‐water overflow. Changes in Karimata Strait exert a particularly influential impact on deep‐water inflow, likely due to its unique position as the sole connecting channel across the Equator.
Blood pressure and cerebral oxygenation with physiologically-based cord clamping: sub-study of the BabyDUCC trial
Authors: Badurdeen Shiraz , Blank Douglas A. , Hoq Monsurul , Wong Flora Y. , Roberts Calum T. , Hooper Stuart B. , Polglase Graeme R. , Davis Peter G.
Published: April 2024

Background

Cord-clamping strategies may modify blood pressure (BP) and cerebral tissue oxygen saturation (rStO2) immediately after birth.

Methods

We conducted a sub-study nested within the Baby-Directed Umbilical Cord-Clamping trial. Infants ≥32+0 weeks’ gestation assessed as requiring resuscitation were randomly allocated to either physiologically-based cord clamping (PBCC), where resuscitation commenced prior to umbilical cord clamping, or standard care where cord clamping occurred early (ECC). In this single-site sub-study, we obtained additional measurements of pre-ductal BP and rStO2. In a separate observational arm, non-randomised vigorous infants received 2 min of deferred cord clamping (DCC) and contributed data for reference percentiles.

Results

Among 161 included infants, n = 55 were randomly allocated to PBCC (n = 30) or ECC (n = 25). The mean (SD) BP at 3–4 min after birth (primary outcome) in the PBCC group was 64 (10) mmHg compared to 62 (10) mmHg in the ECC group, mean difference 2 mmHg (95% confidence interval −3–8 mmHg, p = 0.42). BP and rStO2 were similar across both randomised arms and the observational arm (n = 106).

Conclusion

We found no difference in BP or rStO2 with the different cord clamping strategies. We report reference ranges for BP and rStO2 for late-preterm and full-term infants receiving DCC.

Impact

Among late-preterm and full-term infants receiving varying levels of resuscitation, blood pressure (BP, at 3–4 minutes and 6 min) and cerebral tissue oxygen saturation (rStO2) are not influenced by timing of cord clamping in relation to establishment of ventilation.

Infants in this study did not require advanced resuscitation, where cord clamping strategies may yet influence BP and rStO2.

The reference ranges for BP and rStO2 represent the first, to our knowledge, for vigorous late-preterm and full-term infants receiving deferred cord clamping.

rStO2 > 90% (~90th percentile) may be used to define cerebral hyperoxia, for instance when studying oxygen supplementation after birth.
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
Authors: Cerneckis Jonas , Cai Hongxia , Shi Yanhong
Published: April 2024

The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be differentiated into most somatic cell types. iPSCs have been widely applied to model human development and diseases, perform drug screening, and develop cell therapies. In this review, we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications. We begin by discussing the pivotal discoveries that revealed the potential of a somatic cell nucleus for reprogramming and led to successful generation of iPSCs. We consider the molecular mechanisms and dynamics of somatic cell reprogramming as well as the numerous methods available to induce pluripotency. Subsequently, we discuss various iPSC-based cellular models, from mono-cultures of a single cell type to complex three-dimensional organoids, and how these models can be applied to elucidate the mechanisms of human development and diseases. We use examples of neurological disorders, coronavirus disease 2019 (COVID-19), and cancer to highlight the diversity of disease-specific phenotypes that can be modeled using iPSC-derived cells. We also consider how iPSC-derived cellular models can be used in high-throughput drug screening and drug toxicity studies. Finally, we discuss the process of developing autologous and allogeneic iPSC-based cell therapies and their potential to alleviate human diseases.
Visualizing a single wavefront dislocation induced by orbital angular momentum in graphene
Authors: Liu Yi-Wen , Zhuang Yu-Chen , Ren Ya-Ning , Yan Chao , Zhou Xiao-Feng , Yang Qian , Sun Qing-Feng , He Lin
Published: April 2024

Phase singularities are phase-indeterminate points where wave amplitudes are zero, which manifest as phase vertices or wavefront dislocations. In the realm of optical and electron beams, the phase singularity has been extensively explored, demonstrating a profound connection to orbital angular momentum. Direct local imaging of the impact of orbital angular momentum on phase singularities at the nanoscale, however, remains challenging. Here, we study the role of orbital angular momentum in phase singularities in graphene, particularly at the atomic level, through scanning tunneling microscopy and spectroscopy. Our experiments demonstrate that the scatterings between different orbital angular momentum states, which are induced by local rotational symmetry-breaking potentials, can generate additional phase singularities, and result in robust single-wavefront dislocations in real space. Our results pave the way for exploring the effects of orbital degree of freedom on quantum phases in quasiparticle interference processes.
Moderate greenhouse climate and rapid carbonate formation after Marinoan snowball Earth
Authors: Ramme Lennart , Ilyina Tatiana , Marotzke Jochem
Published: April 2024

When the Marinoan snowball Earth deglaciated in response to high atmospheric carbon dioxide (CO2) concentrations, the planet warmed rapidly. It is commonly hypothesized that the ensuing supergreenhouse climate then declined slowly over hundreds of thousands of years through continental weathering. However, how the ocean affected atmospheric CO2 in the snowball Earth aftermath has never been quantified. Here we show that the ocean’s carbon cycle drives the supergreenhouse climate evolution via a set of different mechanisms, triggering scenarios ranging from a rapid decline to an intensification of the supergreenhouse climate. We further identify the rapid formation of carbonate sediments from pre-existing ocean alkalinity as a possible explanation for the enigmatic origin of Marinoan cap dolostones. This work demonstrates that a moderate and relatively short-lived supergreenhouse climate following the Marinoan snowball Earth is a plausible scenario that is in accordance with geological data, challenging the previous hypothesis.
Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells
Authors: Wang Jing , Zhao Xinyang , Tao Yucheng , Wang Xiuxiu , Yan Li , Yu Kuang , Hsu Yi , Chen Yuncong , Zhao Jing , Huang Yong , Wei Wei
Published: April 2024

Glutamine synthetase (GS) is vital in maintaining ammonia and glutamate (Glu) homeostasis in living organisms. However, the natural enzyme relies on adenosine triphosphate (ATP) to activate Glu, resulting in impaired GS function during ATP-deficient neurotoxic events. To date, no reports demonstrate using artificial nanostructures to mimic GS function. In this study, we synthesize aggregation-induced emission active polyP-Mn nanosheets (STPE-PMNSs) based on end-labeled polyphosphate (polyP), exhibiting remarkable GS-like activity independent of ATP presence. Further investigation reveals polyP in STPE-PMNSs serves as phosphate source to activate Glu at low ATP levels. This self-feeding mechanism offers a significant advantage in regulating Glu homeostasis at reduced ATP levels in nerve cells during excitotoxic conditions. STPE-PMNSs can effectively promote the conversion of Glu to glutamine (Gln) in excitatory neurotoxic human neuroblastoma cells (SH-SY5Y) and alleviate Glu-induced neurotoxicity. Additionally, the fluorescence signal of nanosheets enables precise monitoring of the subcellular distribution of STPE-PMNSs. More importantly, the intracellular fluorescence signal is enhanced in a conversion-responsive manner, allowing real-time tracking of reaction progression. This study presents a self-sustaining strategy to address GS functional impairment caused by ATP deficiency in nerve cells during neurotoxic events. Furthermore, it offers a fresh perspective on the potential biological applications of polyP-based nanostructures.
Impact of dose reductions on adjuvant abemaciclib efficacy for patients with high-risk early breast cancer: analyses from the monarchE study
Authors: Goetz Matthew P. , Cicin Irfan , Testa Laura , Tolaney Sara M. , Huober Jens , Guarneri Valentina , Johnston Stephen R. D. , Martin Miguel , Rastogi Priya , Harbeck Nadia , Shahir Ashwin , Wei Ran , André Valérie , Rugo Hope S. , O’Shaughnessy Joyce
Published: April 2024

In monarchE, adjuvant abemaciclib significantly improved invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS), with sustained benefit beyond the 2-year treatment period. Abemaciclib dose reductions were allowed to proactively manage adverse events. Exploratory analyses to investigate the impact of dose reductions on efficacy were conducted. Across the three patient subgroups as defined by relative dose intensity (≤66%, 66–93%, ≥93%), the estimated 4-year IDFS rates were generally consistent (87.1%, 86.4%, and 83.7%, respectively). In the time-dependent Cox proportional hazard model, the effect of abemaciclib was consistent at the full dose compared to being reduced to a lower dose (IDFS hazard ratio: 0.905; 95% confidence interval: 0.727, 1.125; DRFS hazard ratio: 0.942; 95% confidence interval: 0.742, 1.195). These analyses showed that the efficacy of adjuvant abemaciclib was not compromised by protocol mandated dose reductions for patients with node positive, hormone receptor positive, human epidermal growth factor 2-negative, high-risk early breast cancer.
Structural transitions, octahedral rotations, and electronic properties of A3Ni2O7 rare-earth nickelates under high pressure
Authors: Geisler Benjamin , Hamlin James J. , Stewart Gregory R. , Hennig Richard G. , Hirschfeld P. J.
Published: April 2024

Motivated by the recent observation of superconductivity withTc ~ 80 K in pressurized La3Ni2O71, we explore the structural and electronic properties ofA3Ni2O7bilayer nickelates (A = La-Lu, Y, Sc) as a function of pressure (0–150 GPa) from first principles including a Coulomb repulsion term. At ~ 20 GPa, we observe an orthorhombic-to-tetragonal transition in La3Ni2O7at variance with x-ray diffraction data, which points to so-far unresolved complexities at the onset of superconductivity, e.g., charge doping by variations in the oxygen stoichiometry. We compile a structural phase diagram that establishes chemical and external pressure as distinct and counteracting control parameters. We find unexpected correlations betweenTcand thein-planeNi-O-Ni bond angles for La3Ni2O7. Moreover, two structural phases with significantc+octahedral rotations and in-plane bond disproportionations are uncovered forA = Nd-Lu, Y, Sc that exhibit a pressure-driven electronic reconstruction in the Niegmanifold. By disentangling the involvement of basal versus apical oxygen states at the Fermi surface, we identify Tb3Ni2O7as an interesting candidate for superconductivity at ambient pressure. These results suggest a profound tunability of the structural and electronic phases in this novel materials class and are key for a fundamental understanding of the superconductivity mechanism.
Differences in schizophrenia treatments by race and ethnicity—analysis of electronic health records
Authors: Medina Candice , Akinkunmi Ayooluwa , Bland Nevaeh , Velthorst Eva , Reichenberg Avi , Khachadourian Vahe , Modabbernia Amirhossein , Janecka Magdalena
Published: April 2024

Racial disparities in prescriptions of anti-psychotics have been highlighted before. However, (i) the evidence on other medications, including anti-depressant or mood stabilizing medications is lacking, and (ii) the role of potentially confounding factors and (iii) specificity of such disparities to schizophrenia (SCZ), are still unknown. We used electronic health records (EHRs) from 224,212 adults to estimate the odds ratios of receiving a prescription for different nervous system medications among patients with SCZ of different race/ethnicity, and analogous linear models to investigate differences in prescribed medication doses. To verify specificity of the observed patterns to SCZ, we conducted analogous analyses in depression and bipolar disorder (BD) patients. We found that Black/African American (AA) and Hispanic patients with SCZ were more likely to be prescribed haloperidol (Black/AA: OR = 1.52 (1.33–1.74); Hispanic: OR = 1.32 (1.12–1.55)) or risperidone (Black/AA: OR = 1.27 (1.11–1.45); Hispanic: OR = 1.40 (1.19–1.64)), but less likely to be prescribed clozapine (Black/AA: OR = 0.40 (0.33-0.49); Hispanic: OR = 0.45 (0.35-0.58)), compared to white patients. There were no race/ethnicity-related differences in the prescribed medication doses. These patterns were not specific to SCZ: Asian, Hispanic and Black/AA patients with BD or depression were more likely to be prescribed anti-psychotics, but less likely to be prescribed antidepressants or mood-stabilizers. In conclusion, we found racial/ethnic disparities in the medications prescribed to patients with SCZ and other psychiatric conditions. We discuss the potential implications for the quality of care for patients of diverse races/ethnicities.
Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Authors: Brosey Chris A. , Link Todd M. , Shen Runze , Moiani Davide , Burnett Kathryn , Hura Greg L. , Jones Darin E. , Tainer John A.
Published: April 2024

Drug discovery relies on efficient identification of small-molecule leads and their interactions with macromolecular targets. However, understanding how chemotypes impact mechanistically important conformational states often remains secondary among high-throughput discovery methods. Here, we present a conformational discovery pipeline integrating time-resolved, high-throughput small-angle X-ray scattering (TR-HT-SAXS) and classic fragment screening applied to allosteric states of the mitochondrial import oxidoreductase apoptosis-inducing factor (AIF). By monitoring oxidized and X-ray-reduced AIF states, TR-HT-SAXS leverages structure and kinetics to generate a multidimensional screening dataset that identifies fragment chemotypes allosterically stimulating AIF dimerization. Fragment-induced dimerization rates, quantified with time-resolved SAXS similarity analysis (kVR), capture structure–activity relationships (SAR) across the top-ranked 4-aminoquinoline chemotype. Crystallized AIF–aminoquinoline complexes validate TR-SAXS-guided SAR, supporting this conformational chemotype for optimization. AIF–aminoquinoline structures and mutational analysis reveal active site F482 as an underappreciated allosteric stabilizer of AIF dimerization. This conformational discovery pipeline illustrates TR-HT-SAXS as an effective technology for targeting chemical leads to important macromolecular states.
Rate splitting with semantics as a generalized multi-access framework for intelligent reflecting surfaces
Authors: Jagatheesaperumal Senthil Kumar , Yang Zhaohui , Hassan Md. Rafiul , Hassan Mohammad Mehedi , Fortino Giancarlo
Published: April 2024

The rapid advancement of modern communication technologies necessitates the development of generalized multi-access frameworks and the continuous implementation of rate splitting, augmented with semantic awareness. This trend, coupled with the mounting pressure on wireless services, underscores the need for intelligent approaches to radio signal propagation. In response to these challenges, intelligent reflecting surfaces (IRS) have garnered significant attention for their ability to control data transmission systems in a goal-oriented and dynamic manner. This innovation is largely attributed to equitable resource allocation and the dynamic enhancement of network performance. However, the integration of rate-splitting multi-access (RSMA) architecture with semantic considerations imposes stringent requirements on IRS platforms to ensure seamless connectivity and broad coverage for a diverse user base without interference. Semantic communications hinge on a knowledge base-a centralized repository of integrated information related to the transmitted data-which becomes critically important in multi-antenna scenarios. This article proposes a novel set of design strategies for RSMA-IRS systems, enabled by reconfigurable intelligent surface synergizing with semantic communication principles. An experimental analysis is presented, demonstrating the effectiveness of these design guidelines in the context of Beyond 5G/6G communication systems. The RSMA-IRS model, infused with semantic communication, offers a promising solution for future wireless networks. Performance evaluations of the proposed approach reveal that, despite an increase in the number of users, the delay in the RSMA-IRS framework incorporating semantics is 2.94% less than that of a RSMA-IRS system without semantic integration.
Superovulation with an anti-inhibin monoclonal antibody improves the reproductive performance of rat strains by increasing the pregnancy rate and the litter size
Authors: Mochida Keiji , Morita Kohtaro , Sasaoka Yoshio , Morita Kento , Endo Hitoshi , Hasegawa Ayumi , Asano Masahide , Ogura Atsuo
Published: April 2024

Rats are multiparous rodents that have been used extensively in research; however, the low reproductive performance of some rat strains hampers the broader use of rats as a biomedical model. In this study, the possibility of increasing the litter size after natural mating in rats through superovulation using an anti-inhibin monoclonal antibody (AIMA) was examined. In outbred Wistar rats, AIMA increased the number of ovulated oocytes by 1.3-fold. AIMA did not affect fertilization and subsequent embryonic development, resulting in a 1.4-fold increase in litter size and a high pregnancy rate (86%). In contrast, conventional superovulation by eCG/hCG administration decreased the pregnancy rate to 6–40% and did not increase the litter size. In inbred Brown Norway rats, AIMA increased the litter size by 1.2-fold, and the pregnancy rate increased more than twice (86% versus 38% in controls). AIMA also increased the litter size by 1.5-fold in inbred Tokai High Avoiders and Fischer 344 rats. AIMA increased the efficiency of offspring production by 1.5-, 2.7-, 1.4-, and 1.4-fold, respectively, in the four rat strains. Thus, AIMA may consistently improve the reproductive performance through natural mating in rats, which could promote the use of AIMA in biomedical research.
Sex-specific associations between the environmental exposures and low-grade inflammation and increased blood pressure in young, healthy subjects
Authors: Marchewka Wojciech M. , Bryniarski Krzysztof L. , Marchewka Jakub M. , Popiołek Iwona , Dębski Grzegorz , Badacz Rafał , Marchewka Ida , Podolec-Szczepara Natalia , Jasiewicz-Honkisz Barbara , Mikołajczyk Tomasz P. , Guzik Tomasz J.
Published: April 2024

Long-term exposures to environmental factors including airborne as well as noise pollutants, are associated with cardiovascular risk. However, the influence of environmental pollution on the young population is controversial. Accordingly, we aimed to investigate the relationships between long-term exposures to different environmental factors and major cardiovascular and inflammatory parameters and biomarkers in young, healthy subjects. Representative sample of permanent residents of two cities differing in air and noise pollution levels, aged 15–21 years, were recruited. Krakow and Lublin, both located in southern Poland, were chosen in relation to their similarities in demographic and geopolitical characteristics, but differences in air pollution (higher in Krakow) and noise parameters (higher in Lublin). A total of 576 subjects were studied: 292 in Krakow and 284 in Lublin. All subjects underwent health questionnaire, blood pressure measurements and biomarker determinations. Inflammatory biomarkers, such as CRP, hs-CRP, fibrinogen as well as homocysteine were all significantly higher in subjects living in Krakow as opposed to subjects living in Lublin (for hsCRP: 0.52 (0.32–0.98) mg/l vs. 0.35 (0.22–0.67) mg/l; p < 0.001). Increased inflammatory biomarker levels were observed in Krakow in both male and female young adults. Interestingly, significant differences were observed in blood pressure between male and female subjects. Males from Krakow had significantly higher mean systolic blood pressure (127.7 ± 10.4 mm/Hg vs. 122.4 ± 13.0 mm/Hg; p = 0.001), pulse pressure (58.7 ± 8.9 mm/Hg vs. 51.4 ± 12.3 mm/Hg; p < 0.001) and lower heart rate (p < 0.001) as compared to males living in Lublin. This was not observed in young adult females. Long-term exposure to environmental factors related to the place of residence can significantly influence inflammatory and cardiovascular parameters, even in young individuals. Interestingly, among otherwise healthy young adults, blood pressure differences exhibited significant variations based on biological sex.
Improved phase-to-height mapping method combine with device attitude
Authors: Han Shuhuan , Yang Yanxi , Li Xinjie , Zhao Xubo , Zhang Xinyu
Published: April 2024

Phase-to-height mapping is one of the important processes in three dimensional phase measurement profilometry. But, in traditional phase-to-height mapping method, the measurement accuracy is affected by device attitude, so it needs saving a large amount of mapping equations to achieve high-quality phase-to-height mapping. In order to improve that, this paper proposes an improved phase-to-height mapping method combine with device attitude. Firstly, we get the unwrapped phase of the target. Then, using generalized regression neural network is used to reduce the offset of phase information at the same height due to the randomness of device attitude. Last, the phase-to-height mapping is completed by substituting the unwrapped phase (the difference between having detected object and no detected object) of eliminate the offset into improved phase-to-height mapping method. Experimental results show that the proposed method could achieve high-quality phase-to-height mapping with less mapping equation and less memory space. Compared with the nonlinear phase-to-height mapping method (probabilistic neural network to eliminate phase offset), its accuracy is improved by 44.30%. Compared with the nonlinear phase-to-height mapping method (radial basis function neural network to eliminate phase offset), the accuracy is improved by 39.58%.
The transcription factor STE12 influences growth on several carbon sources and production of dehydroacetic acid (DHAA) in Trichoderma reesei
Authors: Schalamun Miriam , Hinterdobler Wolfgang , Schinnerl Johann , Brecker Lothar , Schmoll Monika
Published: April 2024

The filamentous ascomycete Trichoderma reesei, known for its prolific cellulolytic enzyme production, recently also gained attention for its secondary metabolite synthesis. Both processes are intricately influenced by environmental factors like carbon source availability and light exposure. Here, we explore the role of the transcription factor STE12 in regulating metabolic pathways in T. reesei in terms of gene regulation, carbon source utilization and biosynthesis of secondary metabolites. We show that STE12 is involved in regulating cellulase gene expression and growth on carbon sources associated with iron homeostasis. STE12 impacts gene regulation in a light dependent manner on cellulose with modulation of several CAZyme encoding genes as well as genes involved in secondary metabolism. STE12 selectively influences the biosynthesis of the sorbicillinoid trichodimerol, while not affecting the biosynthesis of bisorbibutenolide, which was recently shown to be regulated by the MAPkinase pathway upstream of STE12 in the signaling cascade. We further report on the biosynthesis of dehydroacetic acid (DHAA) in T. reesei, a compound known for its antimicrobial properties, which is subject to regulation by STE12. We conclude, that STE12 exerts functions beyond development and hence contributes to balance the energy distribution between substrate consumption, reproduction and defense.
Changing epidemiology of parvovirus B19 in the Netherlands since 1990, including its re-emergence after the COVID-19 pandemic
Authors: Russcher Anne , van Boven Michiel , Benincà Elisa , Verweij E. J. T. , Molenaar-de Backer Marijke W. A. , Zaaijer Hans L. , Vossen Ann C. T. M. , Kroes Aloys C. M.
Published: April 2024

Parvovirus B19V (B19V) infection during pregnancy can be complicated by potentially life-threatening fetal hydrops, which can be managed by intrauterine transfusion (IUT). This study investigates the long-term temporal patterns in the epidemiology of B19V and evaluates the impact on fetal hydrops, by combining data on B19V infections from the Dutch Sentinel Surveillance system in the period 1990 to 2023, Dutch blood banking data and hospital data on fetal hydrops. Using wavelet analysis, we identified annual epidemic cycles in the Netherlands in the period 1990–2019 and we identified superimposed multiannual cycles in the period 1990–2009. After 2009, no multiannual cycle could be identified, although the incidence fluctuated and correlates with number of IUT performed. As of 2020, weekly reports of B19V infection demonstrated a historically low incidence and B19V-DNA positive blood donors were nearly absent. From May 2020 to May 2023, no IUT for B19V-related hydrops was performed. In the spring of 2023, B19V infections re-emerged, reaching pre-pandemic epidemic levels. Due to the changes in B19V epidemiology over the last 30 years and the near-absence of B19V during the COVID-19 pandemic, the resulting low immunity levels may lead to rebound outbreaks. Alertness to severe complications such as fetal hydrops is warranted.
Regionally-triggered geomagnetic reversals
Authors: Terra-Nova Filipe , Amit Hagay
Published: April 2024

Systematic studies of numerical dynamo simulations reveal that the transition from dipole-dominated non-reversing fields to models that exhibit reversals occurs when inertial effects become strong enough. However, the inertial force is expected to play a secondary role in the force balance in Earth’s outer core. Here we show that reversals in numerical dynamo models with heterogeneous outer boundary heat flux inferred from lower mantle seismic anomalies appear when the amplitude of heat flux heterogeneity is increased. The reversals are triggered at regions of large heat flux in which strong small-scale inertial forces are produced, while elsewhere inertial forces are substantially smaller. When the amplitude of heat flux heterogeneity is further increased so that in some regions sub-adiabatic conditions are reached, regional skin effects suppress small-scale magnetic fields and the tendency to reverse decreases. Our results reconcile the need for inertia for reversals with the theoretical expectation that the inertial force remains secondary in the force balance. Moreover, our results highlight a non-trivial non-monotonic behavior of the geodynamo in response to changes in the amplitude of the core-mantle boundary heat flux heterogeneity.
Global warming significantly increases the risk of Pierce’s disease epidemics in European vineyards
Authors: Giménez-Romero Àlex , Iturbide Maialen , Moralejo Eduardo , Gutiérrez José M. , Matías Manuel A.
Published: April 2024

Pierce’s disease (PD) is a vector-borne disease caused by the bacteria Xylella fastidiosa, which affects grapevines in the Americas. Currently, vineyards in continental Europe, the world’s largest producer of quality wine, have not yet been affected by PD. However, climate change may alter this situation. Here we incorporate the latest regional climate change projections into a climate-driven epidemiological model to assess the risk of PD epidemics in Europe for different levels of global warming. We found a significant increase in risk above $$+\,2\,^{\circ }\hbox {C}$$

+

2

∘

C

in the main wine-producing regions of France, Italy and Portugal, in addition to a critical tipping point above $$+\,3\,^{\circ }\hbox {C}$$

+

3

∘

C

for the possible spread of PD beyond the Mediterranean. The model identifies decreasing risk trends in Spain, as well as contrasting patterns across the continent with different velocities of risk change and epidemic growth rates. Although there is some uncertainty in model projections over time, spatial patterns of risk are consistent across different climate models. Our study provides a comprehensive analysis of the future of PD at multiple spatial scales (country, Protected Designation of Origin and vineyard), revealing where, why and when PD could become a new threat to the European wine industry.
Influence of different factors on coseismic deformation of the 2015 Mw7.8 earthquake in Nepal
Authors: Wu Rui , Dong Xibin , Xia Bo , Wang Weisi , She Xiayu , Chu ZiMing
Published: April 2024

In Geophysics, topographic factors are observations that can be directly measured, but they are often ignored to simplify the model. Studying the coseismic deformation caused by earthquakes helps accurately determine the epicenter's parameterization. It provides a reference for the reasonable layout of coseismic observation stations and GNSS observation stations. After the Mw7.8 earthquake in Nepal in 2015, GCMT, USGS, GFZ, CPPT, and other institutions released their epicenter parameter. However, according to their parameters, the coseismic displacements simulated by the spectral-element method are quite different from the GNSS observations. Firstly, this paper inverts the geometric parameters of the seismogenic fault with Nepal’s coseismic GNSS displacement. The spectral-element method determines the source's location and depth under the heterogeneous terrain and outputs the source parameters. Among the results of many studies, the surface source is more consistent with the generation mechanism of large earthquakes. Secondly, this paper calculates the fault slip distribution of this earthquake using SDM (Steepest Descent Method) based on GNSS and InSAR data, which is divided into 1500 subfaults, and the moment tensor of each subfault is calculated. This paper investigates the distribution characteristics of the coseismic deformation field of the 2015 Mw 7.8 earthquake in Nepal under three different models. The results show that the influence of topographic factors is ~ 20%, and the influence of heterogeneous factors is ~ 10%. This paper concludes that the influence of topographic factors is much more significant than that of heterogeneous factors, and the influence of both should be addressed in coseismic deformation calculations.