bluuebunny/crossref_metadata_2025 huggingface dataset:
FATP2 regulates osteoclastogenesis by increasing lipid metabolism and ROS production
Authors: Kong Xiangxi , Tao Siyue , Ji Zhongyin , Li Jie , Li Hui , Jin Jiayan , Zhao Yihao , Liu Junhui , Zhao Fengdong , Chen Jian , Feng Zhenhua , Chen Binhui , Shan Zhi
Published: March 2024

Lipid metabolism plays a crucial role in maintaining bone homeostasis, particularly in osteoclasts (OCs) formation. Here, we found that the expression level of FATP2, a transporter for long-chain and very-long-chain fatty acids, was significantly upregulated during OC differentiation and in the bone marrow of mice fed a high-fat diet (HFD). Notably, the use of FATP2 siRNA or a specific inhibitor (Lipofermata) resulted in significant inhibition of OC differentiation, while only slightly affecting osteoblasts. In pathological models of bone loss induced by LPS or ovariectomy, in vivo treatment with Lipofermata was able to rescue the loss of bone mass by inhibiting OC differentiation. RNA sequencing revealed that Lipofermata reduced fatty acid β-oxidation and inhibited energy metabolism, while regulating ROS metabolism to decrease ROS production, ultimately inhibiting OC differentiation. Treatment with Lipofermata, either in vivo or in vitro, effectively rescued the overactivation of OCs, indicating that FATP2 regulated OC differentiation by modulating fatty acid uptake and energy metabolism. These findings suggested that targeting FATP2 may represent a promising therapeutic approach for pathological osteoporosis.
Providing rigor in bee colony strength auditing methods
Authors: Cook Daniel , Hauxwell Caroline
Published: March 2024

The primary method used to audit honey bee (Apis mellifera Linnaeus, 1758 [Hymenoptera: Apidae]) colony strength for almond pollination services, Nasr et al.’s (1990) frame-top cluster count method, is a subjective visual audit that relies on an auditor’s spot assessment and may lack rigor and repeatability. We created novel, open-source software for the analysis of frame-top cluster count photographic assessments to improve methodological rigor and repeatability. We evaluated 2 existing visual audit methods, created 3 novel audit method variations, and determined between-method conversion factors using linear modeling. The software has potential applications in apiological research, apiarist and orchardist colony auditing, as well as training future generations of apiarists in auditing techniques. The software enhances the rigor and repeatability of Nasr et al.’s (1990) frame-top cluster count population assessment. In this article, we introduce the novel open-source software and between-method regression equations and review the tested visual assessment methods and their application.
Mitochondrial genomes of Nemourinae species (Plecoptera: Nemouridae) and the phylogenetic implications
Authors: Wang Ying , Guo Caiyue , Yue Xiaoxiao , Fan Xing , Fan Yuying , Cao Jinjun
Published: March 2024

Currently, the classification system of 2 subfamilies within Nemouridae has been widely accepted. However, monophyly of 2 subfamilies has not been well supported by molecular evidence. To date, only mitogenomes from genus Nemoura of the subfamily Nemourinae were used in previous phylogenetic studies and produced conflicting results with morphological studies. Herein, we analyzed mitogenomes of 3 Nemourinae species to reveal their mitogenomic characteristics and to examine genus-level classification among Nemouridae. In this study, the genome organization of 3 mitogenomes is highly conserved in gene order, nucleotide composition, codon usage, and amino acid composition. In 3 Nemourinae species, there is a high variation in nucleotide diversity among the 13 protein-coding genes (PCGs). The Ka/Ks values for all PCGs were far lower than 1, indicating that these genes were evolving under purifying selection. The phylogenetic analyses highly support Nemurella as the sister group to Ostrocerca. Meanwhile, Nemoura is recovered as the sister group of Malenka; they are grouped with other Amphinemurinae and emerged from a paraphyletic Nemourinae. More molecular data from different taxonomic groups are needed to understand stoneflies phylogeny and evolution.
(043) Gender-Affirming Bilateral Orchiectomy Prior to Vaginoplasty versus with Vaginoplasty: A Comparison of Preoperative Goals and Postoperative Satisfaction
Authors: Stelmar J , Zaliznyak M , Mallavarapu S , Sandhu S , Smith S , Garcia M
Published: March 2024

Introduction

Gender-affirming bilateral orchiectomy (GA-BO), defined here as either a standalone procedure and/or precursor to vaginoplasty, is associated with a decrease in gender-affirming hormone therapy (GAHT) dosages. In comparison to bilateral orchiectomy at time of gender-affirming vaginoplasty (GA-V), GA-BO is associated with shorter waitlist times, procedure duration, and outpatient recovery. While objective benefits of GA-BO have been described, there is limited qualitative data that assesses the preoperative goals and postoperative satisfaction of patients who elect GA-BO. We aim to assess the decision-guiding factors that led patients to select GA-BO, and to compare measures of patient satisfaction between GA-BO and GA-V patients.

Objective

To assess the decision-guiding factors that led patients to select gender-affirming bilateral orchiectomy before vaginoplasty versus with vaginoplasty, and to compare measures of patient satisfaction between groups.

Methods

A retrospective chart review identified 170 patients who underwent GA-BO (n=106; 64%) or GA-V (n=64; 36%) between 4/2017 and 12/2020 at our institution. Patients were emailed a link to an anonymous, online questionnaire (QualtricsTM).

Results

136/170 (80%) patients completed the questionnaire: 86/136 (63%) respondents were GA-BO patients and 50/136 GA-V (37%). 78/86 (91%) of GA-BO respondents had either subsequently undergone vaginoplasty, or, planned to do so in the future. For patients who later underwent vaginoplasty, the mean reported time interval between GA-BO and vaginoplasty was 15 months [Range: 1–34 months]. Respondents prioritized the following expectations in their decision to undergo GA-BO: potential to decrease GAHT medications and dosages (reported as important by 67%), low rates of complications (56.5%), short recovery time (51.6%), and low postoperative pain (46.2%). GA-BO and GA-V patients reported high postoperative improvement in various indices of gender dysphoria and body image, with only 1/4 indices of gender dysphoria differing significantly between the two groups (Figure 1). Unsurprisingly, GA-V patients reported a significantly greater improvement in 3/3 body image indices.

Conclusions

GA-BO is a low-risk procedure that provides a more immediate option to decrease gender dysphoria and improve QOL. All patients who were assigned male at birth and are interested in genital gender-affirming surgery should be made aware of the advantages of GA-BO and offered GA-BO alongside GA-V.

Disclosure

No.
(054) Novel Use of Clitoral Pulse Sensor During Arousal
Authors: Pearlman A , Winter A , Jameson C , Numbers J , Mcmonigal A , Justin E , Hotaling J
Published: March 2024

Introduction

Penile erection is well understood in men and has been extensively studied. The Erectile Hardness Score is a commonly used tool to quantify the strength of an erection. No such measurement tool exists for women. This study builds on the work done by Mechelmans et al exploring Clitoral Pulse Amplitude (CPA) as a marker for physical arousal in women. CPA has been shown to be related to clitoral blood volume, erection, and engorgement of the clitoris. This erection in the clitoris is homologous to penile erection.

Objective

To test a new clitoral pulse sensor for correlation with subjective arousal for proof of concept. To test the comfort and usability of such a device configured with an internal (vaginal) portion and a clitoral portion.

Methods

In the study, 20 healthy female participants wore the device while watching a control (non-arousing) video and during progressively more sexually arousing activities. They were allowed to choose their own materials to watch, read, or listen to for arousal, and a masturbation phase was included for additional information. Participants also reported their subjective arousal after each phase. After the test, participants were also surveyed about the comfort and usability of the device.

Results

The main outcome measures are CPA, subjective sexual arousal, and usability feedback ratings. The pulse sensor successfully detected CPA and results show that most participants had increasing levels of subjective arousal correlating with increasing CPA. Statistical correlation between CPA and arousal was positive but low, which could be attributed to differences of sensor calibration and/or device placement by participants. Overall, this positive relationship indicates that a commercially available pulse sensor could be integrated into a future device to measure physical arousal in women, a metric which was previously not widely available. Furthermore, participants reported high satisfaction with the comfort and usability of the device. These insights give us confidence that this device shape will be comfortable and usable in further iterations. Eventually, we hope to commercialize a similar device which would give women greater insights into their sexual health and provide valuable information to their doctors.

Conclusions

This study showed a positive relationship between CPA and subjective sexual arousal, opening possibilities for future measurement devices. Participants felt the device was very comfortable and easy to use, suggesting this form factor with vaginal (internal) and clitoral (external) portions is a viable configuration for further development. We anticipate improving both the pulse sensing system and device usability as the device is further commercialized.

Disclosure

Yes, this is sponsored by industry/sponsor: FirmTech.

Clarification: Industry initiated, executed and funded study.

Any of the authors act as a consultant, employee or shareholder of an industry for: FirmTech.
(056) The Association Between Disgust Sensitivity, Sexual Desire, Relationship Satisfaction in Finland
Authors: Al Haj Baqir B , Jern P
Published: March 2024

Introduction

Disgust is a basic emotion directed towards certain objects to avoid harm (Angyal, 1941), mainly pathogens. Research, however, has proposed a heterogeneity of disgust beyond pathogen avoidance to generate the functional model, which proposed the functionally distinct domains of disgust: moral, pathogen, and sexual. This model proposes that sexual disgust is an avoidance of sexual contact with unfit partners that may yield unfit offspring (Tybur & de Vries, 2013), this may be due to other anxiety related disorders (Davey, 2011 and Troop et al., 2002)

Objective

This study focuses on the association between disgust sensitivity with sexual desire, and relationships satisfaction. Hypothesis: elevated levels of disgust sensitivity are negatively associated with sexual desire and relationship satisfaction.

Methods

Invitation letters were sent out to the registered Finnish population in the Finnish Central Population Registry to participate in a(n) (online) survey, 9,319 individuals responded to the invitation and completed the survey and agreed to participate in the research. The tools used in this study were Perceived Relationship Quality Component (PRQC), Sexual Desire Inventory (SDI), and the Three-Disgust Domain Scale (TDDS).

Results

The results indicate that the sexual desire and sexual disgust sensitivity, are negatively correlated, the relationship satisfaction correlations are positive except the men pathogen disgust which is a negative correlation between pathogen disgust sensitivity and relationship satisfaction. The correlation between the study variables indicated that among men and women sexual disgust is negatively correlated with sexual desire, and the correlation of relationship satisfaction and sexual disgust was positively correlated.

Conclusions

The results show the negative association of sexual disgust with sexual desire, but there is a positive relationship between sexual disgust and relationship satisfaction.

Disclosure

No.
(059) Effects of a Red-Light–Controllable Nitric Oxide Donor, NORD-1, on Diabetes Mellitus-Induced Erectile Dysfunction in Rats
Authors: Hotta Y , Oyama K , Mori T , Kataoka T , Furukawa-Hibi Y , Kimura K
Published: March 2024

Introduction

Diabetes mellitus (DM) often causes erectile dysfunction (ED). Phosphodiesterase-5 inhibitor has limited effects on diabetes mellitus-induced erectile dysfunction (DMED). One contributing factor to this reduced effect is the decreased production of nitric oxide owing to neuropathy and endothelial impairment. To address this issue, we developed a red-light–controllable nitric oxide donor, NORD-1, that successfully enhanced erectile function in intact and cavernous nerve injury model rats.

Objective

In this study, we investigated whether NORD-1 and red-light irradiation could improve DMED in rats.

Methods

Seven-week-old Sprague–Dawley male rats were used. Rats in the DM and sham groups were intravenously administered streptozotocin 50 mg/kg and saline, respectively. One week after treatment, the blood glucose levels of rats in the DM group were found to be over 250 mg/dL. Five weeks after the treatment, we performed a functional study using the measurements of intracavernous pressure (ICP) under the stimulation of the cavernous nerve. The study was performed before and after NORD-1 treatment, both with and without light irradiation. Additionally, we performed an isometric tension study using corpus cavernosum from rats treated with either NORD-1 or a control compound, SiR650.

Results

The ICP/MAP ratio of the DM group was significantly lower than that of the sham group before and after NORD-1 treatment without light irradiation (both P<0.05). However, after NORD-1 treatment with light irradiation, the ICP/MAP ratios of the Sham and DM groups were substantially enhanced compared with that before and after NORD-1 treatment without light irradiation (all P<0.05). The ICP/MAP ratio of the DM group was similar to that of the Sham group under the normal condition before NORD-1 treatment by light irradiation. Moreover, systemic blood pressure was not affected by NORD-1 and light irradiation. In the isometric tension study, rat corpus cavernosum from rats treated with SiR650 showed no changes under red light in both the Sham and DM groups. However, the corpus cavernosum from rats treated with NORD-1 was strongly relaxed by red light in both groups.

Conclusions

NORD-1 and red-light irradiation could improve DMED in STZ-induced DM rats without lowering blood pressure.

Disclosure

No.
(076) Hyaluronic Acid Injection of Penis for Management of Premature Ejaculation: A Systematic Review with Single-Arm Meta-Analysis
Authors: Atmoko W , Savira M
Published: March 2024

Introduction

Premature ejaculation (PE) is the most prevalent male sexual dysfunction globally. Pharmacological treatments as the primary mainstay for PE therapy have drawbacks in systemic effect and possible recurrence after drug cessation. In the last few years, there has been a progressive use of hyaluronic acid (HA) injection in Andrology, including its use to prolong ejaculation latency time by increasing penile glans sensitivity. However, no meta-analysis on its efficacy and safety exists.

Objective

The study aimed to conduct a comprehensive systematic review and single-arm meta-analysis to identify the efficacy and safety of HA injection in the penis for treating PE.

Methods

A systematic search on PubMed, Scopus, and Embase databases were searched from inception to May 31, 2023, according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Risk of bias of included study were carried out based on Cochrane ROB2 and ROBINS-I tools. Intravaginal ejaculatory latency time (IELT) was considered the primary outcome, whereas satisfaction and complication rate were the secondary outcomes. Pooled rate and mean difference with matching 95% confidence level intervals (CIs) in the random effect model were applied in analysis using STATA 18.0 and RevMan 5.4. To ensure the impact of each study, a leave-one-out sensitivity analysis was performed.

Results

Of the 60 studies identified, three clinical trials and six observational studies with low and moderate risk of bias met the inclusion criteria. A total of 616 participants were eligible for meta-analysis. The results found that HA injection, with different techniques, can significantly increase IELT by 239.78 (95% CI 147.14 – 332.43), 202.76 (95% CI 121.86 – 283.66), 164.62 (95% CI 112.19 – 217.06), and 189.01 (95% CI 71.74 – 306.28) seconds at 1, 3, 6, and ≥12 months follow-up. Despite significant heterogeneity among the studies, the sensitivity analysis results were unaffected by the removal of any of the articles. As for safety, the most commonly reported complications were pain, ecchymosis, and papule formation with pooled incidence of 19% (95% CI: 15% – 24%), 8% (95% CI: 5% – 13%), and 5% (95% CI: 3% – 8%), respectively. The majority of adverse events were mild, temporary, and self-limited, although a single case of skin necrosis and vascular emboli had been reported. In addition, patients and their partners also reported increased satisfaction after HA injection.

Conclusions

HA injection in the penile can effectively prolong the ejaculation time by at least a year with tolerable adverse events. Nevertheless, the optimal injection technique, ideal patient candidate, and long-term outcome still need to be determined through additional well-designed trials.

Disclosure

No.
(084) Frequency of Bleeding at First Vaginal Intercourse and Stereotypes Surrounding it: A Pilot Survey of 6370 Russian-Speaking Women
Authors: Nazaralieva A , Niurkina S , Bocharova M
Published: March 2024

Introduction

Despite the fact not all women experience bleeding at first vaginal intercourse (BFVI), in some cultures failure to prove virginity on the wedding night (sheets/garments covered with blood) may have serious consequences for a woman (bullying, domestic violence, shame and even honor killings). Low awareness of the true frequency of BFVI and of individual variation of the anatomy of the hymen may lead to inaccurate conclusions in cases of sexual assault or “virginity testing” (VT) at schools and/or in clinical settings, which can have a drastic impact on the mental health of young women. In cultures where defloration is sacralized, young women tend to choose anal sex instead of vaginal, which bears further risks including higher hazard of HIV; women also tend to seek hymenoplasty often performed in secrecy (in many cases it cannot guarantee bleeding at following intercourse, as intended).

Objective

To evaluate the frequency of stereotypes surrounding BFVI among Russian-speaking women

Methods

An anonymous survey was completed by 6370 Russian-speaking women across different countries who have had at least one vaginal intercourse. We aimed to reach women from varying religious, socioeconomic and educational backgrounds. The survey included questions on whether women experienced BFVI and if not, whether it had any negative consequences; and list of questions regarding their feelings about virginity, hymen reconstruction and sex in general. The questionnaire was distributed by the authors and biomedical bloggers, via social media (Instagram, Facebook, and Telegram). Preliminary results are presented.

Results

Median age was 31 (15–70); 59% were married; 73.6% reported being raised in secular families. 21.2% - in religious families, and 2.1% - in strictly religious. 43,2% respondents denied having any BFVI; 42,3% confirmed BFVI; while 5,3% reported bleeding on following sexual encounters but not on first intercourse. A minority (3,6%) did not remember whether any bleeding was present. Among those who didn’t have BFVI, 75 (2,2%) reported long-lasting conflicts with partners, 166 (5%) reported withdrawal of their partners, 115 (3,5%)– mistrust, 88 (2,7%)– constant blaming, 37 (1,1 %) – emotional abuse, 2 (0,1%) – physical violence. Two hundred twenty-three (3.5%) women experienced VT at school, 76 (1.2%) referred themselves for VT, and 25 (0.4%) did so at the demand of their own family.

Conclusions

Traditions demonstrating BFVI associate with negative emotions and affect marital relationships as well as sexual health of women. Medical professionals should be aware of the frequency of BFVI; anatomy and gynecology books should reflect corresponding scientific findings. Myths about virginity should be addressed via media and opinion leaders to prevent gender based violence.

Disclosure

No.
(105) Arab Patient and Partner Satisfaction Following Malleable Penile Prosthesis Implantation in North Africa and the Middle East
Authors: Ragheb A , Osmonov D , Abdallah M , Abdelbary A , Emadeldin M , Elmarakby A
Published: March 2024

Introduction

Due to the sensitivity of the topic of penile implants for the treatment of refractory erectile dysfunction (ED) in the Middle East and North Africa region, a scarce body of related research is available.

Objective

We aimed at investigating the levels of patient and partner satisfaction after malleable penile prosthesis implantation among the Arab population and its dynamics during and after the first 6 months of surgery.

Methods

This was a prospective 6-month follow-up study of 120 patients undergoing malleable penile prosthesis implantation at our unit by a single surgeon. Three telephone encounters were conducted for each couple at 1 month, 3 months, and 6 months postoperative (PO). We utilized our validated Arabic version of the Modified Erectile Dysfunction Inventory of Treatment Satisfaction (AM-EDITS). During the 1st first encounter, we inquired about the general patient perioperative experience, starting from preoperative counseling till the first month after surgery. The 2nd and 3rd encounters focused on patient and partner satisfaction after implant utilization.

Results

The average ages of the men and their partners were 54.7±8.4 and 32.9±4.6 years, respectively. Levels of anxiety decreased in over 82% of the men in our study upon receiving proper preoperative counseling. Almost all of the patients were happy (96%) with their early PO days with over 50% of them exceeding their expectations. After 3 months, 82.5% of the men were satisfied, describing their erections to be 80% close to natural. Of the 92.5% satisfied partners at 3 months, nearly 80% were highly satisfied. Over 93% of them reported feeling sexually desirable by their husbands. As opposed to the significant rise in men’s overall satisfaction and AM-EDITS index by 11.6% and 5.2 ± 0.8% (P < 0.001), respectively after 6 months PO, partners demonstrated a 12.4% and 5.9 ± 0.8 decline (P < 0.001), respectively, compared to the 3 months follow up.

Conclusions

Malleable penile implants still represent a good quality-of-life treatment option for middle to low-income countries. Time has a positive effect on Arab men’s PO satisfaction as opposed to their partners’. The explanation behind these findings should be investigated in further studies. A proper understanding of the dynamics of patient and partner satisfaction over time may be useful for proper perioperative counseling of both parties to ensure their sustainable satisfaction.

Disclosure

No.
(120) E-Mergir: Preliminary Efficacy of a Digital Psychological Intervention Program for Improving Mental Health, Sexual Health, and Quality of Life of Prostate Cancer Survivors
Authors: Quinta-Gomes A L , Pieramico S , Rocha H , Carvalho J , Nobre P J
Published: March 2024

Introduction

Introduction: Prostate cancer is one of the most common cancers affecting men worldwide. The diagnosis of prostate cancer and associated treatments have a negative impact on people's physical, emotional, and sexual health, compromising their overall well-being and quality of life throughout the course of the disease. Despite the decreased levels of sexual functioning and sexual satisfaction associated with this type of cancer (Quinta-Gomes et al., 2019), patients' access to specialized healthcare and support is still limited. Given their flexibility and convenience, smartphone-based digital interventions can contribute to bridging this gap and constitute an important way to access specialized and personalized supportive care on emotional and sexual health for people with prostate cancer.

Objective

Objective: The present study aims to evaluate the preliminary efficacy of a digital psychological intervention program using smartphones aimed at improving the mental health, sexual health, and quality of life of prostate cancer survivors.

Methods

Methods: A randomized controlled pilot study is underway involving 30 prostate cancer survivors randomly assigned to an experimental group (with access to the program) and a waiting list control group (treatment as usual). The program was structured in five modules to be completed by the participants in a maximum period of 6 weeks while receiving support from a psychologist. The study was approved by an institutional Ethical Board. Acceptability, usability, feasibility, and preliminary efficacy (overall improvement in sexual and relational satisfaction, sexual pleasure, sexual distress, psychopathology, and quality of life) were defined as the main outcomes of this study. Participants' assessments will take place in two moments, before and after the implementation of the program.

Results

Expected results: It is expected that the program and the experimental design adopted will prove to be adequate and have good acceptability by the participants. Improvements in sexual and relational satisfaction, sexual pleasure, sexual distress, psychopathology, and quality of life are also expected for participants using the program compared to those in the waiting-list group.

Conclusions

Conclusions: As a future empirical-based digital psychological intervention program focused on patients' unmet sexual needs, E-mergir will significantly contribute to addressing the emotional and sexual health and quality of life of people with prostate cancer. Funding: Horizon Europe, NORTE-01-0145-FEDER-000057, CCDRN

Disclosure

No.
(130) Multicenter Study Comparing Stripping vs Ligation of Vas Deferens During Microscopic Denervation of Spermatic Cord in Men with Chronic Orchialgia Across the US
Authors: Hammad M A M , El-Achkar A , Barham D , Hsieh M , Mills J , Ziegelmann M , Smith R , Bernie H , Raheem O , Fendereski K , Hotaling J , Yafi F A
Published: March 2024

Introduction

Microdenervation of the spermatic cord (MSCD) is an effective treatment modality for men with intractable scrotal content pain. For patients not interested in preserving fertility, some centers advocate ligation of the vas during denervation while others perfer stripping of the Vas deferens to preserve the vasal artery, hence preserving vasculature to testis and possibly decreasing post operative congestion pain.

Objective

This multicenter study analyzes outcomes of patients that underwent MSCD by either stripping or ligating the vas deferens.

Methods

A retrospective chart review of 85 patients who underwent MSCD from 2020–2023 was performed. Patients’ demographics including history of prior surgical procedures was recorded. Response to surgery was evaluated as either complete resolution of pain, partial resolution of pain or no improvement in pain.

Results

85 patients underwent MSCD with a median (IQR) age of 36 (25.5–46.5) years and median duration of pain of 16 months. 37 patients underwent stripping of vas while 48 underwent ligation of vas during MSCD. Median follow up was 12 months. 21(43.5%) patients had prior inguinal scrotal surgery in ligation group compared to 5 (13.5%) in the stripping group p=0.003. The etiology of pain was similar between the groups. The response to MSCD between the 2 groups was similar (p=0.968), with similar post op complications (Table 1).

Conclusions

In men with intractable chronic scrotal content with no interest in preserving fertility, ligation or stripping of the vas deferens yields similar outcomes with regards to pain resolution. Both techniques are safe with no reports of any testicular atrophy.

Disclosure

Any of the authors act as a consultant, employee or shareholder of an industry for: Advisory board and speaker for Coloplast; consultant for Cynosure; advisory board and speaker for Halozyme; intellectual property with Masimo; advisory board for Promescent; consultant for Sprout; advisory board for Xialla.
(135) Systematic Review on the Association of Peyronie’s Disease Development and Severity to Testosterone Level: Do we Have Enough Data?
Authors: Savira M , Atmoko W
Published: March 2024

Introduction

Exact pathophysiology of Peyronie's disease (PD) are still poorly known with the combination of tissue ischemia to predefined hereditary variables. Due to the anti-inflammatory factors and ability to regulate collagen metabolism and wound healing, androgens have been the subject of several clinical research studying their role in the onset and severity of PD.

Objective

The aim of this study is to investigate the relationship between testosterone level to the development and severity of PD.

Methods

A systematic search on PubMed, Scopus, and Embase was conducted on April 4th, 2023 using the keywords of testosterone, hypogonadism, and Peyronie’s disease. All studies that compare the testosterone levels of the patients with or without PD or evaluate the association of PD severity were considered. Each included studies are evaluated for its quality and risk of bias.

Results

Eleven studies comprising 1.106 patients with PD and 507 control were included. Three of the four studies examining the association of testosterone level to PD development found that testosterone/DHEA-s levels were lower in the PD group compared to the control. In addition, four of seven studies found that the severity or degree of penile curvature among patients with PD has lower testosterone levels. On contrary, only two of six studies support the correlation of testosterone level to penile plaque diameter. In two studies that confirmed the correlation of penile plaque and degree of curvature to testosterone levels, they also found that PD patients with normal or higher testosterone levels responds better to medical treatment.

Conclusions

Contemporary literature on the correlation between PD and testosterone levels shows conflicting results. Although around half of the studies support its possible correlation to penile curvature severity, no definitive conclusion can be made. Further research is warranted to seek the impact of low testosterone level to PD and whether it needs to be routinely evaluated in clinical practice.

Disclosure

No.
(137) Telemedicine for Sexual Health Issues: A Descriptive Cross-Sectional Study
Authors: Poudel R
Published: March 2024

Introduction

Telemedicine has revolutionized healthcare by enabling remote consultations. In the realm of sexual health, it offers a discreet and convenient platform for couples to seek expert advice, receive counseling, and access personalized treatments from the comfort and privacy of their own homes.

Objective

The objective of this study is to examine the predominant sexual health issues in telemedicine consultations and analyze the socio-demographic profiles of the subjects accessing the service.

Methods

The study received ethical clearance from the Institutional Review Committee of the Medical College. A sexual wellness clinic was established within the psychiatry department, operating on specific days. Patients visiting the clinic were provided with a WhatsApp number for teleconsultation. This number was also shared on various social media platforms to reach a wider audience. During the study period, 88 individuals sought telemedicine consultation, of whom 51 presented with one or more sexual health issues and were included in the study after providing informed verbal consent. The subjects' sociodemographic profiles and relevant clinical data were recorded. Diagnosis of sexual dysfunction followed the DSM5 criteria, while other sexual health issues were categorized separately. Data were analyzed using descriptive statistics.

Results

Among 51 subjects 48 were male while 3 were female. Fourty six subjects had some sexual dysfunction while 5 subjects presented with other sexual health issues. Majority of the patients were young. Among sexual dysfunction, premature ejaculation was the most common sexual dysfunction while among sexual health issues, dhat syndrome was the most common one.

Conclusions

In regions with limited access to sexual health services, telemedicine offers a promising alternative, providing accessible and private consultations. This study emphasizes its significance in addressing sexual health concerns and advocates for further integration into mainstream healthcare.

Disclosure

No.
(139) Efficacy of a New Vacuum Erection Device (Vigor 2020) for Erectile Dysfunction in a Retrospective Study in Japan
Authors: Shirai M , Sano M , Anno Y , Ishikawa K , Taniguchi A , Kure A , Uesaka Y , Nozaki T , Fukuhara S , Iwasa A , Kobayashi K , Kato J , Tsujimura A
Published: March 2024

Introduction

Phosphodiesterase 5 inhibitors (PDE5i) are the first-line treatment for erectile dysfunction (ED), but there is in approximately 30% of ineffective patients or contraindicated in patients taking nitrate medications. Although vacuum erection device (VED) is the second line in ED guidelines, they have long been unavailable in Japan, due to the withdrawal of their manufacturers.

Objective

A new VED, Vigor 2020, has now been manufactured and received medical approval by the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan. It is very important to be able to sexual intercourse with VED, recommended in the ED guidelines. We conducted a retrospective observational study of patients with Vigor 2020 in clinical practice.

Methods

We analyzed male patients aged 20 years or older who presented to an outpatient clinic with ED and were treated with Vigor 2020 as a second-line treatment, because PDE5i was ineffective or contraindicated. Sexual and ejaculatory function were assessed using questionnaires [Erection Hardness Score (EHS), International Index of Erectile Function (IIEF), Male Sexual Health Questionnaire for assessing ejaculatory dysfunction (MSHQ-EjD), the numerical rating scale (NRS)].

Results

There were 34 participants who could be evaluated before and after the use of Vigor 2020, with a mean age of 57.85 (27–86) years. Significant improvement in EHS and IIEF total score were observed with the use of Vigor 2020 in all participants. There was a significant improvement in MSHQ-EjD and NRS for participants who had an EHS of 3 or higher after the use of Vigor 2020. But no significant improvement in MSHQ-EjD and NRS for participants who had an EHS of 2 or lower after the use of Vigor 2020. The participants experienced no significant adverse events.

Conclusions

Vigor 2020 may be one treatment tool for ED, as defined in the ED guidelines. There is not only significant improvement of erection with Vigor 2020 but also improvement of ejaculation in cases of significant erectile efficacy.

Disclosure

No.
(144) The Use of Virtual Reality Systematic Desensitization for the Treatment of Psychogenic Erectile Dysfunction: A Pilot Study
Authors: Rodríguez Martínez J E , Dadian R , García Gómez A , Suro Martos A , Martínez Félix A M
Published: March 2024

Introduction

Erectile dysfunction (ED) is a sexual dysfunction that affects the sexual health of millions of men around the world. In recent years, the evidence indicates an increase in cases of ED among individuals under 40 years old. In most cases, the etiology is of psychogenic origin. Cognitive-behavioral therapy (CBT) has been proven effective and remains one of the most widely used treatments for ED in these cases although controlled studies are lacking. One of the most effective CBT techniques is a set of activities performed by a couple, known as systematic desensitization (SD). SD involves gradually exposing the patient to feared intimacy-related activities with their partner. However, many patients do not have a stable partner or do not want their partner to participate in the treatment. Technological advances are helping to create virtual SD programs which are able to reproduce the sights, sounds, and other sensations of the feared situation.

Objective

Our goal is to determine the potential usefulness of a new virtual reality-based SD program for the treatment of psychogenic ED (pED).

Methods

Six sexually active men diagnosed with pED based on criteria for Erectile Disorder from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) completed virtual SD over 8 weeks. The program consisted of one educational session and five different virtual reality audio exercises which were completed at home using a masturbation aid device called Myhixel ED01, that is connected to a smartphone. The five-item Spanish version of the International Index of Erectile Function (IIEF-5) questionnaire was used to assess symptoms before and after the treatment and the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire was used for evaluating satisfaction with treatment.

Results

Patients enrolled had a mean age of 34.83 years (range 27–39) and experienced an improvement in erectile function, mean IIEF-5 score pretreatment was 11(range 9–13) mean posttreatment IIEF score was 18 (range 14–21). The mean EDITS index score at the end of the treatment was 64.70 (range 59–70.25). No adverse effects were reported during the treatment.

Conclusions

This case series suggests that the use of a virtual reality-based SD could be a potentially effective and safe therapeutic option for men with pED. This new treatment would facilitate greater access of men with pED to one of the most commonly used strategies of sexual therapy, as it would no longer require the participation of a partner. Studies with adequate sample sizes, control groups, randomization, and follow-up are needed to determine the effectiveness of this new treatment.

Disclosure

Any of the authors act as a consultant, employee or shareholder of an industry for: NEW WELLNESS CONCEPT SL.
(149) Knowledge About HIV and Stigma Towards HIV-Positive People: A Study on the Italian Population
Authors: Antonelli P , Salvatori G , Giunti D , Borrello L , Dèttore D
Published: March 2024

Introduction

The literature shows that an adequate knowledge about HIV enables individuals to understand the risks associated with virus transmission and encourages the adoption of protective behaviors. Moreover, it reduces stigma and discrimination against people living with the virus, fostering an open and supportive environment for early diagnosis and treatment. Thus, HIV awareness plays a crucial role in preventing the spread of the virus, improving public health and enhancing the quality of life for those affected.

Objective

The objective of our study was to assess the level of knowledge about HIV, particularly concerning transmission, prevention, and testing. We also investigated participants' habits regarding risky behaviors and the use of protection during sexual intercourse. Additionally, we aimed to evaluate how participants' knowledge about HIV influenced their perceived stigma towards HIV-positive individuals. Our hypothesis was that HIV knowledge would be negatively correlated with perceived stigma towards HIV-positive individuals.

Methods

We recruited a sample of 5256 individuals aged between 14 and 69 (M = 23.99, SD = 6.71) who claimed being HIV-negative, as well as a 54-people sample of participants who reported being HIV-positive, aged between 21 and 70 (M = 43.85, SD = 12.49). Participants completed a questionnaire that assessed their knowledge of HIV, sexual habits related to risky behaviors and transmission prevention, and their level of perceived stigma towards HIV-positive individuals.

Results

Both groups displayed good overall knowledge about HIV, as 75% of the HIV-negative group gave 25 (78.1%) correct answers or more and 75% of the HIV-positives gave at least 28 (87.5%) correct answers. Nonetheless, results highlighted poor knowledge concerning the modalities of HIV transmission and risky behaviors, as well as a low use of condoms during sexual intercourse, as well as low rate of HIV testing. Significant but weak correlations were observed between HIV knowledge, age and perceived stigma.

Conclusions

Although our sample demonstrated good overall HIV knowledge, our findings highlighted specific areas that require attention and should be targeted in future awareness campaigns. Perceived stigma showed weak associations with HIV knowledge and participants' age, but further research is necessary to gain a deeper understanding of the factors influencing this construct.

Disclosure

No.
(161) Is there a Difference in Inflatable Penile Prosthesis Mechanical Failure and Infections Rates in Relation to Prostate Cancer Treatment Modality (Radiation Therapy vs Radical Prostatectomy)
Authors: Khalaf Alla K , Mehr J , Green T , Kim D , Wang R
Published: March 2024

Introduction

Inflatable Penile Prosthesis (IPP) implantation as a treatment for ED has high satisfaction rates in the general population; however, there is limited literature on quantification of complication rates as stratified by ED etiology.

Objective

Our aim was to compare mechanical failure and infection rates in patients undergoing IPP implantation for ED following Radical Prostatectomy (RP) versus radiation therapy (RT) for prostate cancer.

Methods

A retrospective chart review from our institutional database was conducted to identify 405 patients who underwent IPP placement at our institution from 2015–2019, then selecting for those whose etiology of ED was following RP or RT. To prevent crossover confounding; patients with history of pelvic radiation or salvage radiotherapy were excluded from the RP group and patients with history of RP were excluded from the RT group. Data was obtained from 75 patients who met criteria for inclusion: 44 patients in the RP group and 31 patients in the RT group. Mechanical failure, infection rates, mean EDITS scores and additional survey questions were compared between the radiation and RP groups.

Results

Patient demographic information and IPP complication and satisfaction rates are listed below in Table 1 and Figure 1. There was a statistically significant difference in number of patients experiencing IPP complications, 19.4% (n=6) of patients in the RT cohort and 4.5% (n=2) in the RP cohort, respectively. There was no statistically significant difference found in stratified complications- infection rates, device erosion rates, mechanical failure rates, or device removal and/or replacement rates between the two groups. The RP cohort had a significantly higher mean Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire score versus the RT cohort, 91.58 to 76.02, respectively.

Conclusions

These preliminary findings, while requiring large-scale follow up, suggest that there is a higher rate of IPP related complications in patients with device placement following RT for prostate cancer versus RP.

Disclosure

No.
(165) Shaeer's Cavernotome: Core Your Way Through Corporal Fibrosis
Authors: Mahmoud O
Published: March 2024

Introduction

Penile prosthesis implantation in scarred corporal bodies is one of the most challenging urologic procedures, with high risks of perforation and/or failure.

Objective

We present Shaeer’s Cavernotome (patent application number PCT/EG2021/050003). This is the forward-cutting cavernotome that relies on the principle of controlled coring rather than forward stabbing, with fibrous tissue accommodated into the hollow core, thereby high efficacy and low risk of perforation.

Methods

This is a prospective study involving 18 patients with severe corporal scarring. Surgery is performed through a peno-scrotal incision with an indwelling urethral catheter. Corporotomies are incised and a 2cm long core of fibrous tissue is excised with scalpel. Shaeer’s Cavernotome (ShC) is introduced and is lodged against the fibrous tissue. Coring proceeds with the stretched corpus or crus held between the thumb and index fingers of the non-dominant hand as a guide, ahead of the tip. ShC doubles as a sizer. Following coring, penile prosthesis implantation proceeds.

Results

Dilation of the corpora cavernosa was successful in 17 out of 18 patients. Average coring time was 8 minutes 3.2. Dilation was up to girth 13 Hegar in 12 patients, and 11 in 5. No perforations or infections were encountered

Conclusions

Shaeer’s Cavernotome is an instrument that facilitates penile prosthesis implantation in scarred corporal bodies. Full excavation of both corpora cavernosa is achievable in under 10 minutes, with low risk for perforation.

Disclosure

No.
(193) Low Intensity Shockwave Therapy in Combination with Phosphodiesterase-5 Inhibitors is an Effective and Safe Treatment Option in Patients with Vasculogenic ED who are PDE5i Nonresponders: A Multicenter Single-Arm Clinical Trial
Authors: Palmieri A , Arcaniolo D , Palumbo F , Verze P , Liguori G , Mondaini N , Falcone M , Idelfonso Scroppo F , Salonia A , Cai T
Published: March 2024

Introduction

Low-intensity shockwave therapy (Li-ESWT) has been shown to be an effective and safe treatment for vasculogenic erectiledysfunction (ED)

Objective

We aim to evaluate the effectiveness and safety of LiESWT in treating patients affected from vasculogenic ED who did not respond to oral treatment with Phosphodiesterase 5 inhibitors (PDE5-i)

Methods

It is a multicentric open-label prospective study, in a cohort of patients non-responders to PDE-5i. Li-ESWT was performed in an outpatient setting by using the following schedule: 3000 shockwaves with an energy of 0.25 mJ/mm2 and a frequency of 4–6 Hz, twice a week for 3 weeks. International Index of Erectile Function, Erection Hardness Score and Sexual Quality of Life-Male questionnaires, and penile doppler ultrasound (PDU) are the outcome measurements.

Results

The Student t-test or Wilcoxon signed-rank test were applied to compare variables, with results considered statistically significant at p < 0.05. 106 (97.2%) completed treatment and performed follow-up visit after 4 weeks. At follow up visit, the mean IIEF-EF increased by 8.6 points (13.47 ± 4.61 vs 22.07 ± 5.27; p < 0.0001). A clinically significant improvement of IIEF-EF was achieved in 75 patients (70.7%). An EHS score ≥ 3, sufficient for a full intercourse, was reported by 72 patients (67.9%) at follow-up visit. 37 (34.9%) patients reported a full rigid penis (EHS = 4) after treatment. Li-ESWT treatment was also able to improve quality of life (SQOL-M: 45.56 ± 8.00 vs 55.31 ± 9.56; p < 0.0001). Li-ESWT significantly increased mean PSV (27.79 ± 5.50 vs 41.66 ± 8.59; p < 0.0001) and decreased mean EDV (5.66 ± 2.03 vs 1.93 ± 2.11; p < 0.0001) in PDU.

Conclusions

Combination of Li-ESWT and PDE5-i represents an effective and safe treatment for patients affected from ED who do not respond to first line oral therapy

Disclosure

No.