bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel and Simplified Score for Determining Treatment Eligibility for Patients with Chronic Hepatitis B
Authors: Geeratragool Tanawat , Tangkijvanich Pisit , Nimanong Supot , Chainuvati Siwaporn , Charatcharoenwitthaya Phunchai , Tanwandee Tawesak , Chotiyaputta Watcharasak
Published: March 2023

Background: International guidelines for hepatitis B infection (HBV) recommend initiating antiviral treatment based on viral replication with inflammation or fibrosis. HBV viral loads and liver fibrosis measurements are not widely available in resource-limited countries. Aim: To develop a novel scoring system for the initiation of antiviral treatment in HBV-infected patients. Methods: We examined 602 and 420 treatment-naïve, HBV mono-infected patients for derivation and validation cohorts. We performed regression analysis to identify parameters associated with the initiation of antiviral treatment based on the European Association for the Study of the Liver (EASL) guidelines. The novel score was developed based on these parameters. Results: The novel score (HePAA) was based on HBeAg (hepatitis B e-antigen), the platelet count, alanine transaminase, and albumin. The HePAA score showed excellent performance, with AUROC values of 0.926 (95% CI, 0.901–0.950) for the derivation cohort and 0.872 (95% CI, 0.833–0.910) for the validation cohort. The optimal cutoff was ≥3 points (sensitivity, 84.9%; specificity, 92.6%). The HePAA score performed better than the World Health Organization (WHO) criteria and the Risk Estimation for HCC in Chronic Hepatitis B (REACH-B) score, and it performed similarly to the Treatment Eligibility in Africa for HBV (TREAT-B) score. Conclusions: The HePAA scoring system is simple and accurate for chronic hepatitis B treatment eligibility in resource-limited countries.
Protein Degradation by Gammaherpesvirus RTAs: More Than Just Viral Transactivators
Authors: Combs Lauren R. , Combs Jacob , McKenna Robert , Toth Zsolt
Published: March 2023

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a member of the Gammaherpesvirus subfamily that encodes several viral proteins with intrinsic E3 ubiquitin ligase activity or the ability to hijack host E3 ubiquitin ligases to modulate the host’s immune response and to support the viral life cycle. This review focuses specifically on how the immediate-early KSHV protein RTA (replication and transcription activator) hijacks the host’s ubiquitin–proteasome pathway (UPP) to target cellular and viral factors for protein degradation to allow for robust lytic reactivation. Notably, RTA’s targets are either potent transcription repressors or they are activators of the innate and adaptive immune response, which block the lytic cycle of the virus. This review mainly focuses on what is currently known about the role of the E3 ubiquitin ligase activity of KSHV RTA in the regulation of the KSHV life cycle, but we will also discuss the potential role of other gammaherpesviral RTA homologs in UPP-mediated protein degradation.
A Risk Factor Analysis of SARS-CoV-2 Infection in Animals in COVID-19-Affected Households
Authors: Kuhlmeier Evelyn , Chan Tatjana , Meli Marina L. , Willi Barbara , Wolfensberger Aline , Reitt Katja , Hüttl Julia , Jones Sarah , Tyson Grace , Hosie Margaret J. , Zablotski Yury , Hofmann-Lehmann Regina
Published: March 2023

A higher prevalence of SARS-CoV-2 infections in animals that have close contact with SARS-CoV-2-positive humans (“COVID-19 households”) has been demonstrated in several countries. This prospective study aimed to determine the SARS-CoV-2 prevalence in animals from Swiss COVID-19 households and to assess the potential risk factors for infection. The study included 226 companion animals (172 cats, 76.1%; 49 dogs, 21.7%; and 5 other animals, 2.2%) from 122 COVID-19 households with 336 human household members (including 230 SARS-CoV-2-positive people). The animals were tested for viral RNA using an RT-qPCR and/or serologically for antibodies and neutralizing activity. Additionally, surface samples from animal fur and beds underwent an RT-qPCR. A questionnaire about hygiene, animal hygiene, and contact intensity was completed by the household members. A total of 49 of the 226 animals (21.7%) from 31 of the 122 households (25.4%) tested positive/questionably positive for SARS-CoV-2, including 37 of the 172 cats (21.5%) and 12 of the 49 dogs (24.5%). The surface samples tested positive significantly more often in households with SARS-CoV-2-positive animals than in households with SARS-CoV-2-negative animals (p = 0.011). Significantly more animals tested positive in the multivariable analysis for households with minors. For cats, a shorter length of outdoor access and a higher frequency of removing droppings from litterboxes were factors that were significantly associated with higher infection rates. The study emphasizes that the behavior of owners and the living conditions of animals can influence the likelihood of a SARS-CoV-2 infection in companion animals. Therefore, it is crucial to monitor the infection transmission and dynamics in animals, as well as to identify the possible risk factors for animals in infected households.
Human Cytomegalovirus Protein Expression Is Correlated with Shorter Overall Survival in Breast Cancer Patients: A Cohort Study
Authors: Touma Joel , Pantalone Mattia Russel , Rahbar Afsar , Liu Yan , Vetvik Katja , Sauer Torill , Söderberg-Naucler Cecilia , Geisler Jürgen
Published: March 2023

Background: Human cytomegalovirus (HCMV) is increasingly suggested to be involved in human carcinogenesis and onco-modulation due to its ability to contribute to all hallmarks of cancer. Growing evidence demonstrates a link between HCMV infection and various malignancies, including breast cancer, which incidence and mortality are still on the rise. The etiology of breast cancer remains mostly unclear, leaving 80% of breast cancer cases considered to be sporadic. Identifying novel risk- and prognostic factors for improved breast cancer treatment and increased survival rates, were the objectives of this study. Methods: Automated immunohistochemical staining results for HCMV proteins in 109 breast tumors and lymph node metastasis were correlated with clinical follow-up data (>10 years). Statistical analyses for median Overall Survival (OS) were performed. Results: Survival analyses revealed shorter median OS for patients with HCMV-IE positive tumors of 118.4 months compared to 202.4 months for HCMV-IE negative tumors. A higher number of HCMV-LA positive cells in the tumors was also associated with a shorter OS in patients (146.2 months vs. 151.5 months). Conclusions: Our findings suggest a link between HCMV-infections and breast cancer prognosis, which paves the way for potential novel clinical intervention and targeted therapy that may prolong the overall survival of selected patients with breast cancer.
An Automated Bioinformatics Pipeline Informing Near-Real-Time Public Health Responses to New HIV Diagnoses in a Statewide HIV Epidemic
Authors: Howison Mark , Gillani Fizza S. , Novitsky Vlad , Steingrimsson Jon A. , Fulton John , Bertrand Thomas , Howe Katharine , Civitarese Anna , Bhattarai Lila , MacAskill Meghan , Ronquillo Guillermo , Hague Joel , Dunn Casey W. , Bandy Utpala , Hogan Joseph W. , Kantor Rami
Published: March 2023

Molecular HIV cluster data can guide public health responses towards ending the HIV epidemic. Currently, real-time data integration, analysis, and interpretation are challenging, leading to a delayed public health response. We present a comprehensive methodology for addressing these challenges through data integration, analysis, and reporting. We integrated heterogeneous data sources across systems and developed an open-source, automatic bioinformatics pipeline that provides molecular HIV cluster data to inform public health responses to new statewide HIV-1 diagnoses, overcoming data management, computational, and analytical challenges. We demonstrate implementation of this pipeline in a statewide HIV epidemic and use it to compare the impact of specific phylogenetic and distance-only methods and datasets on molecular HIV cluster analyses. The pipeline was applied to 18 monthly datasets generated between January 2020 and June 2022 in Rhode Island, USA, that provide statewide molecular HIV data to support routine public health case management by a multi-disciplinary team. The resulting cluster analyses and near-real-time reporting guided public health actions in 37 phylogenetically clustered cases out of 57 new HIV-1 diagnoses. Of the 37, only 21 (57%) clustered by distance-only methods. Through a unique academic-public health partnership, an automated open-source pipeline was developed and applied to prospective, routine analysis of statewide molecular HIV data in near-real-time. This collaboration informed public health actions to optimize disruption of HIV transmission.
Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions
Authors: Koh Jia , Masomian Malihe , Anasir Mohd , Ong Seng-Kai , Poh Chit
Published: March 2023

EV-A71 is a common viral pathogen that causes hand, foot and mouth disease. It is a single-stranded RNA virus that has a low fidelity RNA polymerase and, as a result, spontaneous mutations frequently occur in the EV-A71 genome. The mutations within the genome give rise to quasispecies within the viral population that could be further defined by haplotypes. In vitro virulence of EV-A71 was shown by plaque size in Rhabdomyosarcoma (RD) cells, which was substantiated by in vitro characterizations of growth, RNA replication, binding, attachment and host cell internalization. Viruses could exhibit different host cell adaptations in different cell lines during viral passaging. The EV-A71/WT (derived from EV-A71 subgenotype B4) was shown to comprise six haplotypes through next-generation sequencing, where only EV-A71/Hap2 was found to be cultivable in RD cells, while EV-A71/Hap4 was the only cultivable haplotype in Vero cells. The EV-A71/WT produced plaques of four different sizes (small, medium, big, huge) in RD cells, while only two plaque variants (small, medium) were present in Vero cells. The small plaque variant isolated from RD cells displayed lower RNA replication rates, slower in vitro growth kinetics, higher TCID50 and lower attachment, binding and entry ability when compared against EV-A71/WT due to the mutation at 3D-S228P that disrupted the active site of the RNA polymerase, resulting in low replication and growth of the variant.
Disease Course, Management and Outcomes in Kidney Transplant Recipients with SARS-CoV-2 Infection during the Omicron-Variant Wave: A Single-Center Experience
Authors: Korogiannou Maria , Vallianou Kalliopi , Xagas Efstathios , Rokka Evangelia , Soukouli Ioanna , Boletis Ioannis N. , Marinaki Smaragdi
Published: March 2023

Background: Since December 2019, kidney transplant recipients (KTRs) have experienced a great impact of the coronavirus disease 2019 (COVID-19) pandemic, with a higher risk of morbidity and mortality compared to the general population. Preliminary data in KTRs suggest that the Omicron variant, which has been dominant since December 2021, is more infectious than the previous ones but is associated with reduced risk of severity and low lethality rates. The purpose of our study was to assess the disease course and outcomes of the SARS-CoV-2 infection in KTRs during the Omicron-surge. Methods: This retrospective study included 451 KTRs diagnosed with SARS-CoV-2 infection between 1 December 2021 and 30 September 2022. Demographic and clinical characteristics at the time of infection, vaccination data, treatment, clinical course, and outcomes were recorded and analyzed. Results: Mean age was 51.8 ± 13.7 years with a male predominance (61.2%). The majority (76.1%) were vaccinated with at least three doses of the available mRNA vaccines, although serology revealed low anti-SARS-CoV-2 antibody titers before infection (33 [3.3–1205] AU/mL). Only 6% of the patients experienced moderate–severe disease. Accordingly, there was low prevalence of adverse outcomes, such as SARS-CoV-2-related hospitalization (11.3%) and death (0.9%). Multivariate analysis revealed that only age significantly increased the risk of SARS-CoV-2-related hospitalization. Conclusions: During the Omicron wave, the clinical course of the SARS-CoV-2 infection in KTRs has substantially changed, with lower rates of moderate and severe disease and a low prevalence of adverse outcomes. Prospective clinical trials are warranted to further elucidate the evolving pathogenesis, management, and long-term outcomes of COVID-19 in such high-risk populations.
Vaccine Candidates against Arenavirus Infections
Authors: Saito Takeshi , Reyna Rachel A. , Taniguchi Satoshi , Littlefield Kirsten , Paessler Slobodan , Maruyama Junki
Published: March 2023

The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment facility, biosafety level-4 (BSL-4). Vaccines and treatments are very limited for these pathogens. The development of vaccines is crucial for the establishment of countermeasures against highly pathogenic arenavirus infections. While several vaccine candidates have been investigated, there are currently no approved vaccines for arenavirus infection except for Candid#1, a live-attenuated Junin virus vaccine only licensed in Argentina. Current platforms under investigation for use include live-attenuated vaccines, recombinant virus-based vaccines, and recombinant proteins. We summarize here the recent updates of vaccine candidates against arenavirus infections.
Hydraulic Conductivity Tests in the Triaxial Stress State: Is Peat an Aquitard or an Aquifer?
Authors: Kaczmarek Łukasz , Grodzka-Łukaszewska Maria , Sinicyn Grzegorz , Grygoruk Mateusz , Jastrzębska Małgorzata , Szatyłowicz Jan
Published: March 2023

The characteristics of peat’s are crucial for understanding natural processes and their suitable shaping through the management of water relations. This study focused on the results of one of the first hydraulic conductivity (k) laboratory tests of exemplary peat samples from the Biebrza Valley (a peatland of very high environmental importance) in relation to the stress state and hydraulic gradient. Further, the research was devoted to a specific test procedure of peat permeability as a key feature for landform development in wetlands. Detailed tests of dark brown/black samples were selected as the reference for the research investigations. Four long-term test series of water permeability were performed in a modified triaxial compression apparatus. In all selected hydraulic gradient variants (i = 5,10,25,40,55,85), the k values decreased from 6 × 10−8 m/s to 1.6 × 10−10 m/s with a stepwise increase in the effective confining pressures tested (10, 15, 30, 45, and 90 kPa). These results were related to the inherent soil features—a relatively high peat decomposition and external driver—confining pressure (radial stress) magnitude. Compared to the other Polish peat tests, the determined k values were at the lower end of their hydraulic conductivity range. The analysed organic soil is not a typical aquifer. Despite very high porosities (~88%) and a high organic matter content (81.1–89.4%) which is favourable for water accumulation, the characterized peat showed relatively low hydraulic conductivity values. Thus, this specific soil may differentiate the groundwater flow as it complicates strong contact with surface water.
Study on the Deposition Reduction Effect of the Sediment–Sluice Tunnel in Zengwen Reservoir
Authors: Lo Wei-Cheng , Huang Chih-Tsung , Wu Meng-Hsuan , Chen Boris Po-Tsang , Tan Hsi-Nien
Published: March 2023

Reservoirs are a crucial part of the human water supply system. The effectiveness and service life of a reservoir is decided mainly by its storage capacity, and as such, preventing reservoir capacity loss is of high interest worldwide. Due to climate change in recent years, precipitation types have changed, and heavy rainfall events have become more severe and frequent. Rainfall causes soil erosion in slope lands and transports large amounts of sediment downstream, forming deposition. This causes reservoir storage capacity to fall rapidly and decreases reservoir service life. The Sediment–Sluice Tunnel can reduce rapid deposition in reservoirs and is, thus, widely employed. By simulating sediment transportation in reservoirs, deposition reduction after building the Sediment–Sluice Tunnel can be evaluated. This study used the Physiographic Soil Erosion–Deposition (PSED) model to simulate the flow discharge and suspended sediment discharge flowing into the Zengwen reservoir then used the depth-averaged two-dimensional bed evolution model to simulate the sediment transportation and deposition in a hydrological process. Simulation results showed that the Sediment–Sluice Tunnel effectively reduced deposition and transported sediment closer to the spillway and Sediment–Sluice Tunnel gate. The deposition distribution with the Sediment–Sluice Tunnel built is more beneficial to the deployment of other dredging works.
Characterization and Disinfection by Product Formation of Dissolved Organic Matter in Anaerobic–Anoxic–Oxic Membrane Bioreactor (AAO-MBR) Process
Authors: Ren Xueli , Wang Feng , Zhang Yajing , Wang Jiali , Miao Hengfeng
Published: March 2023

In the process of sewage treatment, the characteristics of dissolved organic matter (DOM) are always changed during chemical and biological processes, affecting the generation of disinfection by-products (DBPs) compositions at the following disinfection stage. The present study systematically investigated the effect of DOM characterization on C- and N-DBPs formation at AAO-MBR reactor when treating wastewater. The results showed that the AAO-MBR treatment process could efficiently eliminate dissolved organic carbon (DOC) and ammonium nitrogen (NH4+-N) from wastewater with an elimination rate of 89% and 98%, respectively. Most of the precursors (i.e., 56.8% C-DBPs and 78.1% N-DBPs) were removed at the MBR unit, while AGC and AAO units promoted the formation of DBPs precursors. More specifically, soluble microbial products (SMPs) and humus acid were increased, which led to improved C- and N-DBPs via aerated grit chamber (AGC) treatment. At the AAO treatment unit, the content of low MW hydrophobic SMPs, humus acid, and polysaccharides was increased, indicating low MW and HPO fractions dominating the C- and N-DBPs. MBR treatment improved C-DBPs in high MW and HPO fractions and N-DBPs in low MW and HPO fractions, which is explained by higher MW hydrophobic SMPs and humus acids, compared to the AAO unit. The present study provided deep insight into the linkage of DOM characteristics and C- and N-DBPs formation at each treatment unit during the AAO-MBR process.
Assessing the Hydrochemistry, Groundwater Drinking Quality, and Possible Hazard to Human Health in Shizuishan Area, Northwest China
Authors: Xiao Shan , Fang Yuan , Chen Jie , Zou Zonghua , Gao Yanyan , Xu Panpan , Jiao Xueke , Ren Miaoyue
Published: March 2023

Groundwater is an important source of drinking water, particularly in arid regions. In this study, a total of 66 groundwater samples were collected from the phreatic aquifer in the Shizuishan area, a traditional irrigation region of Ningxia. The results showed that the TDS values were above the drinking water standards for nearly 50% of the groundwater samples. The ions followed the order of Na+ > Ca2+ > Mg2+ > K+ and SO42− > Cl− > HCO3− in the groundwater. There were four dominant factors in controlling groundwater chemistry based on principal component analysis: the salinity factor, alkalinity factor, carbonate factor, and pollution factor. The high concentration of NH4-N in groundwater was attributed to agricultural activities, but the high NO3-N levels were mainly due to sewage or wastewater. F and As were derived from geogenic sources. Based on the result of the WQI assessment, about 40% of the samples in the central part of the study region showed unacceptable water quality for drinking, which was mainly associated with high NH4-N, TDS, and As concentrations. The total non-carcinogenic risks of drinking the groundwater were 0.05–10.62 for adults and 0.09–20.65 for children, respectively. The order of pollutants in the groundwater in terms of their hazard to residents was: As > F− > NO3-N > NH4-N. The carcinogenic risk values of As through oral ingestion for children and adults were 0–7.37 × 10−4 and 0–1.89 × 10−4, respectively. Chronic exposure by oral ingestion presented as the main source of susceptibility to exposure to groundwater contaminants for children.
Dynamic Coupling Model of Water Environment of Urban Water Network in Pearl River Delta Driven by Typhoon Rain Events
Authors: Shen Weiping , Jin Yuhao , Cong Peitong , Li Gengying
Published: March 2023

Typhoon rain dominates meteorology-rainfall-runoff-environmental factor changes at the regional scale and regulates water resources in the river network area by means of multi-field coupled meteorological, hydrological, and geographic models, shaping complex water resources and water environment scenarios in the Pearl River Delta. Because of limitations in the monitoring capacity of the typhoon process, quantifying the ephemeral processes and spatial heterogeneity information of typhoon rain events is difficult, which makes the degree of research on typhoon rainfall-runoff transformation processes low and the progress in regional water resources and water environment evaluations based on typhoon events slow. In this study, typhoon rain event data, namely, remote-sensing spectra, measured water quality parameters, and meteorological factors, in the Pearl River Delta during 2022 were first collected. Next, a dynamic coupling model between typhoon rain events and the water network environment was established to simulate and predict the water environment conditions of the Zhongshan City water network controlled by the regulation of typhoon rain events. By inputting the quantitative data of the typhoon rain events, the water environment conditions of the river network in Zhongshan City after the typhoon rain events were simulated and output. The results showed that the distribution of dissolved oxygen concentrations and ammonia nitrogen concentrations were consistent: the concentration was highest in the central urban area, which is more urbanised than other areas, and it was lowest in the area far from the urban centre. Moreover, under the influence of Typhoon Ma-on, the water environment of the Zhongshan City water network changed over time: dissolved oxygen concentrations decreased and then increased, and ammonia nitrogen concentrations increased and then decreased. The water quality prediction model proposed in this study helps to improve the understanding of the dynamic impact of typhoon rain on the water quality of an urban water network in the Pearl River Delta and is conducive to improving the formulation of water environment control strategies during typhoon transit.
A Hybrid Coupled Model for Groundwater-Level Simulation and Prediction: A Case Study of Yancheng City in Eastern China
Authors: Hou Manqing , Chen Suozhong , Chen Xinru , He Liang , He Zhichao
Published: March 2023

The over-exploitation of groundwater has led to a significant drop in groundwater levels, which may lead to a series of geological disasters and ecological environmental problems such as ground subsidence and ground cracks. Therefore, through studying the dynamic change characteristics of groundwater, we can grasp the dynamic changes in groundwater level over time and invert the hydrogeological parameters, which provides an important basis for the management of groundwater resources. In this study, the confined aquifer III groundwater between 2005 and 2014 in Yancheng City was selected as the research object, and the Back Propagation (BP) neural network, Spatial-temporal Auto Regressive and Moving Average (STARMA) model, and BP-STARMA model were used to predict the spatial and temporal evolution trends of groundwater. In order to compare the prediction effectiveness of the BP-STARMA model, the fitting and prediction accuracies of the three models were measured from the perspectives of time and space. The results of the Relative Squared Error (RSE), Normal Mean Squared Error (NMSE), Root-Mean-Squared Error (RMSE), and Mean Absolute Error (MAE) were used to assess the robustness of the BP-STARMA model. The results showed that the fitting of the RMSE of BP-STARMA model was reduced by 39.92%, 38.35%, 30.25%, 31.55%, and 13.57% compared with the STARMA model, and by 22.2%, 8.7%, 15.9%, 28.5%, and 4.42% compared with the BP neural network model, respectively. Collectively, this shows that the BP-STARMA model has a better spatiotemporal prediction of groundwater level than the STARMA and BP neural network models, is more applicable to spatially continuous time-discrete spatiotemporal sequences, and is more applicable to spatiotemporal sequences that respond to natural geographic phenomena.
Water Pipeline Leak Detection Based on a Pseudo-Siamese Convolutional Neural Network: Integrating Handcrafted Features and Deep Representations
Authors: Zhang Peng , He Junguo , Huang Wanyi , Zhang Jie , Yuan Yongqin , Chen Bo , Yang Zhui , Xiao Yuefei , Yuan Yixing , Wu Chenguang , Cui Hao , Zhang Lingduo
Published: March 2023

The detection of leaks in water distribution systems (WDS) has always been a major concern for urban water supply companies. However, the performance of traditional leak detection classifiers highly depends on the effectiveness of handcrafted features. An alternative method is to use a convolutional neural network (CNN) to process raw signals directly to obtain deep representations that may ignore prior information about the leakage. The study proposes a novel approach to leak detection in WDS using ground acoustic signals, and demonstrates the effectiveness of combining handcrafted features and deep representations using a pseudo-siamese convolutional neural network (PCNN) model. Mel frequency cepstral coefficient (MFCCs) are selected as additional handcrafted features to traditional time- and frequency-domain (TFD) features. Based on the results of the model performance evaluation, the optimized PCNN model performs better than other methods, with an accuracy of 99.70%. A quantitative analysis of the PCNN demonstrates the effectiveness of handcrafted features and deep representations. Model visualization and interpretation analysis show that feature fusion occurs in the feedforward of the PCNN, hence improving the model’s performance. The present work can effectively support the development of novel intelligent leak detection equipment for WDS.
Selected Worldwide Cases of Land Subsidence Due to Groundwater Withdrawal
Authors: Tzampoglou Ploutarchos , Ilia Ioanna , Karalis Konstantinos , Tsangaratos Paraskevas , Zhao Xia , Chen Wei
Published: March 2023

The present review paper focuses on selected cases around the world of land subsidence phenomena caused by the overexploitation of aquifers. Land subsidence is closely related to human activity. In particular, the development of technology has led to an exponential increase in industrial and agricultural production, as well as extensive urbanization, mainly in large cities. The action of those parameters, along with the effects of climate change, has led to further increases in water demands, which have mainly been served by overexploitation of the aquifers. Overexploitation, in conjunction with broader geo-tectonic conditions, can trigger severe land subsidence phenomena, resulting in significant damage affecting the physical and man-made environment. The scope of the present study is to provide a critical review of the existing literature on land subsidence due to aquifer overexploitation and highlight the main causal factors driving this process. The methods developed in the past and their outcomes hold significant importance in sustainable development strategic planning.
Academic and Corporate Vehicle Electrification Research
Authors: Pohl Hans , Karlström Magnus
Published: March 2023

We developed and used methodology to analyze scientific publications in Scopus relating to vehicle electrification and associated key enabling technologies: batteries, fuel cells and electric machines with power electronics. The global research landscape was mapped, and an analysis of the 16 most active countries was carried out. Vehicle electrification publications are rewarded with a high citation impact, and they include corporate actors to a great extent. China dominates in vehicle electrification research as well as in the enabling technologies, and China’s position is set to become even more dominating. Battery research has grown rapidly with a high citation impact, whereas the volume of research for the other enabling technologies was more constant during 2017–2021. Automakers’ research that has led to scientific publications was specifically studied. Ford Motor Company was the automaker with the highest number of vehicle electrification publications during 2017–2021. A large share of the automakers’ publications was co-authored with academic actors, and such publications were rewarded with a higher citation impact than those without. However, the share of international co-publications among the automakers was meager. It is concluded that the analysis of vehicle electrification publications gives an overview of the rapidly developing field. Moreover, the analysis of automakers’ involvement in such research is one way of obtaining one perspective on their strategies and priorities.
Values and Solidarity of Young Finnish Millennials and Generation X
Authors: Helve Helena Marketta
Published: March 2023

It has been claimed that, in many countries and societies, there has been a generational change in youth values towards postmodern values that indicate postmaterialism. This paper tests that proposition by comparing youth values and solidarity attitudes in the Nordic welfare state of Finland among Generation X (born in the 1960s and 1970s) and Millennials (born in the 1980s and 1990s). The data were gathered from young people in 1992, 1995, 2011, and 2015 by same attitude scales relating to solidarity, environmental issues, gender, work, science and technology, immigration, economic well-being, and politics. Factor analysis was used to identify the value structures of young people. Common to the value structures of both generations were humanism, traditionalism, individualism, and globalism. The findings indicate a decline in postmaterialist values during the periods of economic recession, which affected solidarity attitudes. It was easier, for example, to show solidarity towards people of one’s own country than to people of foreign countries. Generation X youth presented a more socio-democratic type of solidarity towards citizens, while Millennials showed liberal solidarity towards the poor. Young females of both generations were more likely to support postmaterialistic values, such as gender equality, tolerance of different ethnic groups, globalization, and environmentalism. By contrast, young males had more materialist values and greater faith in science and technology. Positive attitudes towards the future were found among young Millennials, which could support the broad identity horizon. Young people of Millennials showed greater variety in their value structures than the young people of Generation X. They revealed neoliberal attitudes in their value structures, which came closer to the ideology of economic liberalization. Nationalist values were also found among the young people of Millennials. The research findings and implication will be critically discussed.
Avaliação do controle de plantas daninhas submetidas a aplicação de herbicidas de diferentes modos de ação e tamanho de gotas
Authors: Hoffmann Gabriel , Nogueira dos Anjos Danilo , Oliveira Castro Yuri de
Published: March 2023

A falta de controle das plantas daninhas, pode influenciar diretamente na produtividade da cultura. Por isso, o objetivo desse trabalho, foi avaliar o controle de plantas daninhas com dois tipos de produtos, com modos de ação sistêmico (Glifosato) e de contato (Paraquat), com três diferentes tamanhos de gotas (fina, média e grossa). O trabalho foi realizado em Confresa-MT, em delineamento em blocos casualizados (DBC), com seis tratamentos e quatro repetição. A aplicação dos herbicidas foi com uma bomba costal a base de CO2, com uma barra de 2 metros, e com quatro bicos, com 50 cm entre eles. A análise estatística do resultado da aplicação dos herbicidas, mostrou que houve significância a 5% de probabilidade para a variável modo de ação nas avaliações 3, 6, 9 e 38 dias após a aplicação dos herbicidas (DAA). Para as avaliações 12 e 14 DAA, não houve diferença significativa para nenhum fator avaliado. O Paraquat teve um controle superior aos 3, 6 e 9 DAA, aos 12 e 14 DAA, os dois produtos tiveram o mesmo nível de controle, e aos 38 DAA o Glifosato obteve um controle superior. Em relação ao tamanho de gotas, não teve diferença significativa em nenhuma das avaliações.
Aplikasi Kalkulator Full Costing UD Roti Bakery dengan Visual Basic 6.0
Authors: Fatimah Novia , Wigiyanti Wigiyanti
Published: March 2023

Konsumen selalu tertarik pada produk/jasa berkualitas dengan harga yang kompetitif. Harga kompetitif dapat dicapai dengan menekan biaya produksi. Untuk menekan biaya produksi, perusahaan harus cermat menentukan harga pokok produksi. Salah satu cara menentukannya dengan menggunakan metode full costing, yaitu metode perhitungan harga pokok produksi dengan cara menghitung seluruh biaya tetap dan variabel. UD Roti Bakery yang bergerak dibidang produksi roti manis di Jakarta Selatan, menghitung harga pokok produksi secara manual. Sering terjadi kesalahan pada proses tersebut karena unsur biaya yang akan dihitung tidak sedikit sehingga proses memasukkan datanya dan proses menghitung dapat berulang kembali untuk memastikan kebenaran hasil perhitungan. Hal ini sangat tidak efisien. Dengan tujuan mengefisienkannya, penulis membangun aplikasi sederhana berbasis komputer menggunakan pemrograman Visual Basic 6.0 dan metode Rapid Application Development berdasarkan data laporan keuangan UD Roti Bakery periode Januari 2020. Penelitian ini menggunakan metode kuantitatif dan kualitatif karena data berupa angka-angka dan diperoleh melalui wawancara dan catatan pengamatan langsung dengan pihak perusahaan. Hasil akhir penelitian ini berupa aplikasi komputer siap pakai berbasis desktop bernama Aplikasi Kalkulator Full Costing UD Roti Bakery dengan batasan hanya untuk operator UD Roti Bakery dan tidak dapat memasukkan lebih dari satu tanggal untuk data yang sama. Aplikasi ini berimplikasi memberi warna lain dalam komputerisasi perhitungan harga pokok produksi dengan metode full costing.
Pengelolaan Keuangan Pribadi Menggunakan Teknologi Citra Digital Berbasis Website
Authors: Purwanto Heri , Nugraha Rikky Wisnu , Hamdani Deden Sofyan , Rizky Mohamad
Published: March 2023

Pengelolaan keuangan merupakan suatu tindakan untuk mencukupi kebutuhan keuangan pada masa mendatang dan juga dapat digunakan untuk menyelesaikan masalah ekonomi pribadi maupun kelompok. Pengelolaan keuangan dibutuhkan untuk menangani persoalan keuangan yang terjadi dalam kehidupan. Pengeluaran biaya sehari-hari yang semakin bertambah, menjadi satu dari beberapa sebab pentingnya mengatur keuangan pribadi agar tidak terjebak dalam hutang. Masyarakat juga belum terbiasa dalam mengelola keuangannya, sehingga sering terbebani dengan pengeluaran yang tidak terduga. Dengan mengelola keuangan yang tepat, dapat berguna untuk membantu terlaksananya setiap tujuan individu. Penelitian ini bertujuan untuk mengembangkan aplikasi yang telah dirancang sebelumnya oleh peneliti terdahulu, sistem dibuat dengan berbasis website demi fleksibilitas pengguna, dan ditambahkan fitur menggunakan teknologi citra digital menambahkan fitur input data pemasukan dan pengeluaran keuangan berupa scan uang dan scan struk belanja. Metodologi yang digunakan dalam penelitian ini adalah metode Agile, metodologi ini berfokus kepada kepuasan pelanggan dan juga kecepatan pembuatan program. Teknik pengumpulan data menggunakan studi pustaka dan bahasa pemodelan yang digunakan adalah Unified Modelling Language (UML). Berdasarkan hasil pengujian, sistem ini mampu diakses melalui berbagai sistem operasi yang memiliki koneksi internet dan browser, sehingga memudahkan pengguna dalam memanfaatkan berbagai fasilitas yang ada dalam sistem. Sistem ini dapat dikembangkan lebih jauh dengan menambahkan fitur yang dapat mengingatkan pengguna dalam penggunaan uang, seperti notifikasi limit penggunaan keuangan.
PELATIHAN PENGAJARAN DARING YANG EFEKTIF DAN MENARIK MENGGUNAKAN GOOGLE MEET DI PKBM DAARUL ADAB BANDUNG
Authors: Zarman Wendi
Published: March 2023

Dengan adanya berbagai pembatasan aktifitas akibat adanya wabah Covid-19, dunia pendidikan harus beralih dari pembelajaran tatap muka (PTM) ke pembelajaran jarak jauh (PJJ) berbasis internet (daring). Agar pembelajaran daring dapat mencapai tujuannya, guru perlu menerapkan metode yang tepat dalam menyampaikan materi pelajarannya. Sehubungan dengan itu, penulis telah melakukan pelatihan metode penyampaian materi pembelajaran daring kepada guru-guru PKBM Daarul Adab, Kota Bandung. Tujuan pelatihan ini adalah agar para guru dapat memahami perbedaan PTM dan pembelajaran daring dan kemudian menerapkan metode pembelajaran daring secara menarik dan efektif. Melalui pelatihan ini guru dapat memahami langkah-langkah yang diperlukan dalam melaksanakan pembelajaran daring. Selain itu diperoleh temuan bahwa kefektifan pembelajaran daring tidak hanya ditentukan oleh kepiawaian guru dalam mengajar tapi juga kelengkapan sarana dan prasarana yang dimiliki siswa.
PERANCANGAN VIDEO PROMOSI PRODUK PUSAT PENELITIAN TEH DAN KINA (PPTK) GAMBUNG
Authors: Hardoyo Adityo Baskoro , Albar Deni , Haq Muthia Shafika , Soegoto Eddy Soeryanto , Warlina Lia , Tarmawan Irwan , Maryati Mari
Published: March 2023

Fakultas Desain Universitas Komputer Indonesia yang telah bekerjasama dengan Puat Penelitian Teh dan Kina (PPTK) melaksanakan pelayanan kepada masyarakat berupa perancangan/ pembuatan iklan video. Metode pelaksanaan kegiatan pengabdian pada masyarakat ini dilakukan dengan beberapa cara baik bertemu langsung dengan pihak PPTK, maupun diskusi secara online. Adapun metode yang digunakan dalam pembuatan video adalah dengan metode langsung berupa Design Thinking yaitu mitra diajak berperan serta sebagai klien. Video Iklan Produk PPTK Gambung ini telah di upload ke Youtube pada tanggal 9 Februari 2022 dengan dengan judul “Gamboeng White Tea Baik bagi Menjaga Kesehatan dan Kecantikan Wanita” dengan link https://youtu.be/vAcjEw9xeeo. Video yang telah dirancang ini sejalan dengan penelitian tentang white tea yang menyatakan bahwa produk ini perlu didorong untuk komersialisasi dengan melakukan promosi yang tepat sasaran.
Training of museum studies experts and educators: design and implementation of the integrated certificate programme
Authors:   Mariupol State University, Kyiv, Sabadash Juliia , Marakhovska Nataliia ,   Mariupol State University, Kyiv
Published: March 2023

The aim of the study is to explore the peculiarities of obtaining the qualification of a museum studies expert and educator by higher education seekers within the framework of the integrated certificate program “Museum pedagogy”. The article describes domestic and foreign experience of training specialists for the integrated field of museum pedagogy. The analysis of the scientific literature shows that while defining a museum educator researchers give primary importance either to museum or pedagogical component of their work. Therefore, the authors provide a comprehensive definition for a specialist in the field of museum pedagogy in the paper. It is shown that a museum studies expert and educator is able to combine cultural and pedagogical expertise and skills, develop teaching technologies through museums, design a museum-educational environment, experiment with museum and pedagogical methods and techniques. The content of the two-year certificate programme designed and implemented on the basis of Mariupol State University is comprised of ten three-credit academic disciplines, inter alia,“Museum Studies”, “History of Arts”, “Cultural Studies”, “Preservation of Historical Monuments of Ukraine”, “Practicum on Perception of Contemporary Art”, “Modern Museum Communications”, “Museum Didactics”, “Methodology of Museum Education”, “Art Pedagogy” and “Pedagogical Practicum”. In the focus of the programme are: acquisition of theoretical knowledge in museum studies, familiarisation with museum development in Ukraine and all over the world; enhancing the understanding of cultural and art orientations; development of skills to design and organise the educational process in institutions of general secondary education by means of museum pedagogy, and create a museum-educational environment. The paper gives rationale for the core competencies for a prospective museum studies expert and educator, enumerates the learning outcomes of the integrated certificate programme. The authors provide the requirements for text and visual content of the programme presentation.
50 years of chronicle discourse of the department of event-industries, culturology and museum studies of Rivne state humanitarian university
Authors:   Mariupol State University, Kyiv, Sabadash Juliia , Nikolchenko Yuzef ,   Mariupol State University, Kyiv
Published: March 2023

Peer-reviewed monograph "Higher Cultural Education in Ukraine: Regional Discourse (through the prism of the Department of Event Industries, Cultural Studies and Museum Studies of Rivne State University for the Humanities)", prepared for publication by Doctor of Cultural Studies, Professor, Professor of the Department of Event Industry and Culture Vytkalov, is the first attempt in domestic historiography to comprehensively study the system of higher cultural education in Ukraine, based on 50 years of experience of the Department of Event Industries, Cultural Studies and Museum Studies of Rivne State University for the Humanities, formed in 1971 within the Rivne Faculty of Culture and Education of the Kyiv State Institute of Culture, and later (since 1979) - Rivne State Institute of Culture and (since 1998) - in RDGU. The use of historical-analytical method, system-functional approach and network analysis allowed the author of the monograph to comprehensively analyze the trends in the development of higher cultural education in the western region of Ukraine in its historical retrospective. In a highly professional clarification of the essence of educational and scientific activities of the staff of the department for 50 years, the author originally used the form of the Chronicle as a traditional method of phased coverage of events. This is a complete picture of the directions and effectiveness of its work not only in the system of higher cultural education in Ukraine, but also the development of culture and art in Volyn, Zakarpattia, Ivano-Frankivsk, Lviv, Rivne, Ternopil, Khmelnytsky, Chernivtsi regions provided by the graduates of the department according to the state order. The monograph will be useful for scientists, students, cultural workers; it is a significant contribution of the lecturers of the Department of Event Industries, Cultural Studies and Museum Studies of Rivne State University for the Humanities to the development of Ukrainian cultural studies.
The festival as a convivial cultural practice
Authors:   Kyiv National University of Culture and Arts, Haidukevych Kateryna
Published: March 2023

The scientific research reveals the characteristics of the festival as a cultural form, defines its structure, functions and social purpose. General and special features of the festival as a festive practice are described (its purpose, ontological foundations, cultural potential). The research methodology focused on the systematic approach allowed to apply the comparative, historical and cultural, typological and analytical methods. The ability of the festival to improve social relations, smooth over difficulties and misunderstandings caused by intercultural diversity, create a single cultural space indicates that in the modern world the leading function of the festival is integration and differentiation. The study justifies that in order to initiate systematic festival practices in territorial communities one should take into consideration the following factors: the significance of the cultural potential of the festival; the ability of cultural practices to influence the economic situation of the settlement; the impossibility to realize the festival potential without the support of the government and understanding the importance of culture as social capital by its representatives; the co-ordination of common interests between the cultural and artistic environment and the local community; having a common understanding of social and cultural problems and ways to solve them. The author proves that the festival, forming an open symbolic and cultural space for dialogue, acts as a «cultural mediator» between different social groups of society. The implementation of communicative, educational, entertainment functions and the function of a direct participation contributes to achieving the goal. In modern society, the festival is not only a powerful factor in strengthening social capital as such, which stimulates the economic, cultural, and educational development of the local community; the festival represents and, at the same time, produces patterns of cultural development for the near future. It creates its own cultural product, actualizing modern culture, as it combines different cultural practices in a single project.
Lexis to Denote Emotions: Problems and Prospects of Creating Word List
Authors:   the National University of “Kyiv-Mohyla Academy”, Dalebiha Olesia
Published: March 2023

The article discussed the researches about emotions which were done by Ukrainian scholars in the field of linguistics, analyzes ways to create a list of emotion-related words and criteria for their selection, suggests methods and criteria that can be used to distinguish words to denote emotions in the Ukrainian language. According to the results of the research, most linguistics works in Ukraine about emotions study semantic fields and idiomatic-semantic fields of specific emotions. Methods and criteria for selecting words to describe emotions in English, German, Polish, Korean, Estonian, Chinese, and Ukrainian were analyzed. The following most common methods were identified: field research, selection of words to denote emotions from individual texts and corpora, and selection of words from lexicographical sources. The article analyzes how words to denote emotions can be selected in the Ukrainian language from lexicographic sources on the example of an explanatory dictionary and a dictionary of synonyms. The criteria that can be relied on in such a selection of words are proposed. In particular, to distinguish words to denote emotions using an explanatory dictionary, we can generally suggest the following way: 1. Analyze through which word the words that exactly belong to emotions are most often interpreted. In our case, it is the word «почуття» (feeling). 2. From the dictionary, write out the words that are interpreted through “почуття + word in the genitive case”. 3. Write out the words that are interpreted through “те саме, що (the same as) + one of the words from the list obtained at the previous stage”, “протилежне (opposite) + one of the words from the list already obtained”, “див. (see) + one of the words from the already received list”. 4. Write out the words that are interpreted through synonyms for words from the already obtained list. To separate words to denote emotions using a dictionary of synonyms, we suggest the following way: 1. Choose the source words that exactly are emotion labels. 2. Write out the synonyms for these words from the dictionary. 3. Write out the synonyms to the list of words obtained at the previous stage (to avoid the words that are not related to emotions, but have become a part of the synonymous series due to the homonymy and polysemanticism of words, the meaning of words could be checked in the explanatory dictionary according to the criteria described in the previous method).