bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS FAKTOR-FAKTOR YANG MENENTUKAN RATING OBLIGASI SYARIAH PADA PERUSAHAAN-PERUSAHAAN YANG TERDAFTAR DI BEI TAHUN 2015-2017
Authors: Elviza  , Maryasih Lilis
Published: December 2024

The research aims to analyze the factors that determine the rating of sharia bonds in companies listed on the Indonesia Stock Exchange. The factors tested in this research are profitability ratios, liquidity ratios, solvency ratios and bond life as independent variables while the sharia bond rating is the dependent variable. The research sample consisted of 29 company bonds that were listed on the Indonesia Stock Exchange (BEI) and submitted financial reports to Bapepam in the 2015-2017 period. The data used in this research is secondary data and the sample selection used the purposive sampling method. The analytical tools used are discriminant analysis and logistic regression analysis. The results of hypothesis testing show that all variables can be used to determine bond ratings for companies that issue sharia bonds and are listed on the Indonesia Stock Exchange (BEI). Hypothesis testing using logistic regression analysis shows that 29 companies that issued sharia bonds from 2015 to 2017 had a high liquidity value, so the company received a bond rating with an AAA investment grade rating.
Lidt om kæmpe-menneskeaber
Authors: Nielsen Eigil
Published: December 2024

Intet resumé
Her og der. Turen går til Møn
Authors: Floris Søren
Published: December 2024

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Jeg - en spordanner
Authors: Bromley Richard
Published: December 2024

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Sjældne mineraler fra Sydgrønland
Authors: Schwartz Gitte
Published: December 2024

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Granit
Authors: Maaløe Sven
Published: December 2024

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Bornholms grundfjeld
Authors: Berthelsen Asger
Published: December 2024

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San Fransisco, 1838, 1966, 1989, ?
Authors: Håkansson Eckart , Madsen Lena
Published: December 2024

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Nyt geologisk kort over Danmark
Authors: Pedersen Stig Asbjørn Schack
Published: December 2024

Intet resumé
Kystklinten ved Lodbjerg
Authors: Sjørring Steen
Published: December 2024

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Basalter i Østgrønland
Authors: Larsen Lotte Melchior
Published: December 2024

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Guld, platin og palladium i Østgrønland
Authors: Larsen Rune B.
Published: December 2024

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Brachiopoder - hvor gik de hen?
Authors: Asgaard Ulla
Published: December 2024

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Nyt om danekræ
Authors: Jakobsen Sten Lennart
Published: December 2024

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En glødende borekerne
Authors: Pedersen Asger Ken , Nygaard Erik , Rønsbo Jørn , Bender-Koch Christian , Buchwald Vagn Fabricius
Published: December 2024

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Geologen og lurmærket
Authors: Jørgensen Gunni
Published: December 2024

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“Stenæbler"
Authors: Håkansson Eckart
Published: December 2024

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Træstubbe på havets bund - eller Syndfloden i Storebælt
Authors: Fischer Anders
Published: December 2024

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Ringe af flint
Authors: Sjørring Steen
Published: December 2024

Intet resumé
Jordbunden i Danmark
Authors: Rasmussen Kjeld
Published: December 2024

Intet resumé
Meteorstenen fra Mern
Authors: Nielsen Erhard
Published: December 2024

Intet resumé
Kvartærgeologi i Thailand
Authors: Skibsted Søren
Published: December 2024

Intet resumé
Et nyt undergrundskort
Authors: Pedersen Stig Asbjørn Schack
Published: December 2024

Intet resumé
Sten- og fingrustællinger
Authors: Sjørring Steen
Published: December 2024

Intet resumé
En fossil jordbund i Østjylland
Authors: Sjørring Steen , Skibsted Søren
Published: December 2024

Intet resumé
Kæmper og andet godtfolk
Authors: Poulsen Valdemar
Published: December 2024

Intet resumé
Tertiær landhævning og erosion
Authors: Japsen Peter
Published: December 2024

Intet resumé
Hvordan kom den amerikanske strandmusling til Europa, før Columbus opdagede Amerika
Authors: Petersen Kaj Strand
Published: December 2024

Intet resumé
Boganmeldelse. Heinz Kowalski, 1992: Trilobiten. Verwandlungskünstler des Palaozoikums.Ein unorthodoxer Streifzug durch das Reich der Dreilapper. Goldschneck-Verlag
Authors: Nielsen Arne Thorshøj
Published: December 2024

Intet resumé
Hinrich Rink og Nicobarerne
Authors: Jørgensen Gunni
Published: December 2024

Intet resumé
Grøndalsboringen - en rekord fra århundredeskiftet
Authors: Svendsen Nick
Published: December 2024

Intet resumé
Søpindsvin – de irregulære
Authors: Asgaard Ulla
Published: December 2024

Intet resumé
Præstens Badekar i Skåne – En jordskælvsbetinget indsynkningsstruktur,
Authors: Hamberg Lars
Published: December 2024

Intet resumé
Historien om jern-titan-oxiderne I
Authors: Jensen Aage
Published: December 2024

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Guld i Grønland
Authors: Stendal Henrik
Published: December 2024

Intet resumé
Boganmeldelse. Nina Rehfeldt: Fra istid til bøgetid,. 2.udg. Natur og Museum, Naturhistorisk Museum, Århus 1994
Authors: Björck Svante
Published: December 2024

Intet resumé
Hvor vokser krystallerne i et magmakammer?
Authors: Wilson J. Richard , Holmboe Anita S.
Published: December 2024

Intet resumé
Iltmangel, sort slam og trilobitter - en kambrisk cocktail
Authors: Nielsen Arne Thorshøj
Published: December 2024

Intet resumé
Ordrup Næs - en ‘ny’ lokalitet for marint Kvartær på Sjælland
Authors: Skibsted Søren
Published: December 2024

Intet resumé
Boganmeldelse. Jørgen Butzbach: Bornholm gennem 1700 millioner år. William Dams Boghandel A/S, 3700 Rønne. 88 sider
Authors: Poulsen Valdemar
Published: December 2024

Intet resumé
Den dynamiske istid
Authors: Björck Svante
Published: December 2024

Intet resumé
Dinosaurernes år i Danmark
Authors: Bonde Niels
Published: December 2024

Intet resumé
Dunede dino’er og fjerede fugle i Kinas Kridt
Authors: Bonde Niels
Published: December 2024

Intet resumé
En fjeldvæg i Kronprins Christian Land, Nordøstgrønland
Authors: Higgins A. K.
Published: December 2024

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Boganmeldelse. Storebælt i 10.000 år – Mennesket, havet og skoven, 339 sider
Authors: Noe-Nygaard Nanna
Published: December 2024

Intet resumé
Oversvømmelserne i Centraleuropa juli 1997,
Authors: Hillefors Åke
Published: December 2024

Intet resumé
Boganmeldelse. Hans Kermit: Niels Steensen - Naturforsker og Helgen
Authors: Poulsen Valdemar
Published: December 2024

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Hafnium - opdagelsen af Københavns grundstof og geokemiske forhold
Authors: Bailey John C.
Published: December 2024

Intet resumé
Fundering af bro i interstadialt søbassin
Authors: Frederiksen John , Rosbirk Erik
Published: December 2024

Intet resumé
På sporet af dinosuarerne
Authors: Nielsen Jesper Milàn
Published: December 2024

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Den store Överskjytningen
Authors: Berthelsen Asger
Published: December 2024

Intet resumé
Boganmeldelse. Bjarne Holm et al. (red): Topografisk atlas Grønland
Authors: Berthelsen Asger
Published: December 2024

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Oceanbund skubbet op på land - Troodos komplekset på Cypern
Authors: Henriksen Niels
Published: December 2024

Intet resumé
Danmarks største krystal
Authors: Madsen Henrik
Published: December 2024

Intet resumé
Anmeldelse. 'Walking with beasts´ – en BBC production
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Foraminiferer – naturens geniale arkitekter
Authors: Nielsen Kurt S. S.
Published: December 2024

Intet resumé
Det nye Geocenter – fra idé til virkelighed
Authors: Sørensen Henning , Ghisler Martin
Published: December 2024

Intet resumé
Anmeldelse. The future is wild – en ZDF production
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Nordøstgrønland – sen prækambrisk til tidlig palæozoisk bassinudvikling
Authors: Stouge Svend , Christiansen Jørgen L. , Harper David. A.T. , Boyce Douglas , Knight Ian
Published: December 2024

Intet resumé
Danekræ – endnu et flot fossil
Authors: Bonde Niels , Jakobsen Sten L.
Published: December 2024

Intet resumé
Guddommelige spiraler – historien bag et mønster, 2
Authors: Asgaard Ulla , Bromley Richard , Uchman Alfred
Published: December 2024

Intet resumé
Boganmeldelse. Jan Lundqvist: Geologi - processer - utvikling - tillämpning, 4:e Uppl.
Authors: Sørensen Henning
Published: December 2024

Intet resumé
Tetrapteryx og flyvning – lidt om flyvning og aerodynamik
Authors: Hansen Kasper , Bonde Niels
Published: December 2024

Intet resumé
Rettelse til Varv 2006-2
Authors: Redaktionen
Published: December 2024

Intet resumé
Różnice między społecznościami energetycznymi a tradycyjnymi uczestnikami rynku energii
Authors:   University of Silesia, Katowice, Kmieć Jakub , Pawełczyk Mirosław ,   Uniwersytet Śląski w Katowicach
Published: December 2024

Celem artykułu jest zidentyfikowanie różnic między społecznościami energetycznymi a tradycyjnymi uczestnikami rynku energii prowadzącymi działalność na obszarze państw członkowskich UE. Poddane analizie zagadnienia należą do obszaru nauk prawnych i ekonomicznych. Badania przeprowadzono przy użyciu metod formalnoprawnej i teoretycznoprawnej. Zidentyfikowane różnice zostały podzielone na różnice o charakterze programowym (obejmujące genezę powstania i rozwoju porównywanych podmiotów, stopień ingerencji państwa oraz zakres oddziaływania regulacji sektorywych na prowadzenie przez nie działalności), różnice o charakterze strukturalnym (dominujące formy prowadzenia działalności, struktura kapitałowa, zakres uprawnień kontrolnych i decyzyjnych członków oraz stopień partycypacji społecznej), różnice o charakterze przedmiotowym (odmienny cel, przedmiot, zakres terytorialny prowadzonej działalności). W wyniku przeprowadzonej analizy różnic sformułowano wniosek, iż społeczności energetyczne są nowymi podmiotami na rynku energii.
Ku globalnemu reżimowi odpowiedzialności cywilnej za szkodę jądrową: potencjalne wybrane skutki przystąpienia Polski do konwencji o dodatkowym odszkodowaniu za szkodę jądrową (CSC)
Authors:   Wydział Prawa i Administracji, Uniwersytet Jagielloński, Nowakowska Patrycja
Published: December 2024

Celem niniejszego artykułu jest przybliżenie etapów rozwoju międzynarodowego reżimu odpowiedzialności cywilnej za szkodę jądrową poprzez opisanie najważniejszych wydarzeń w tym procesie i wyjaśnienie przyczyn zmian, które doprowadziły społeczność międzynarodową do przyjmowania poszczególnych aktów prawa. Centralnym punktem jest ukazanie momentu przyjęcia konwencji o dodatkowym odszkodowaniu za szkodę jądrową w 1997 roku (dalej: konwencja CSC lub CSC). Artykuł opisuje najważniejsze założenia konwencji CSC, prowadząc do analizy potencjalnych wybranych skutków przystąpienia Polski do tego aktu prawa międzynarodowego. Rozważania prowadzone są na tle aktualnej sytuacji sektora jądrowego na świecie i w Polsce, w celu uzmysłowienia, że zagadnienia odpowiedzialności cywilnej za szkodę jądrową mają bezpośredni wpływ na rozwój tej gałęzi gospodarki.
Non-linear transcriptional responses to gradual modulation of transcription factor dosage
Authors: Domingo Júlia , Minaeva Mariia , Morris John A , Ziosi Marcello , Sanjana Neville E , Lappalainen Tuuli
Published: December 2024

Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However, our understanding of how gradual changes in gene dosage affect molecular, cellular, and organismal traits is currently limited. To address this gap, we induced gradual changes in gene expression of four genes using CRISPR activation and inactivation. Downstream transcriptional consequences of dosage modulation of three master trans-regulators associated with blood cell traits (GFI1B, NFE2, and MYB) were examined using targeted single-cell multimodal sequencing. We showed that guide tiling around the TSS is the most effective way to modulate
cis
gene expression across a wide range of fold-changes, with further effects from chromatin accessibility and histone marks that differ between the inhibition and activation systems. Our single-cell data allowed us to precisely detect subtle to large gene expression changes in dozens of
trans
genes, revealing that many responses to dosage changes of these three TFs are non-linear, including non-monotonic behaviours, even when constraining the fold-changes of the master regulators to a copy number gain or loss. We found that the dosage properties are linked to gene constraint and that some of these non-linear responses are enriched for disease and GWAS genes. Overall, our study provides a straightforward and scalable method to precisely modulate gene expression and gain insights into its downstream consequences at high resolution.
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
Authors: Sugimoto Mitsuru , Takagi Tadayuki , Suzuki Tomohiro , Shimizu Hiroshi , Shibukawa Goro , Nakajima Yuki , Takeda Yutaro , Noguchi Yuki , Kobayashi Reiko , Imamura Hidemichi , Asama Hiroyuki , Konno Naoki , Waragai Yuichi , Akatsuka Hidenobu , Suzuki Rei , Hikichi Takuto , Ohira Hiromasa
Published: December 2024

Post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establish a simple PEP risk score model (SuPER model: Support for PEP Reduction) that can be applied before ERCP.This multicenter study enrolled 2074 patients who underwent ERCP. Among them, 1037 patients each were randomly assigned to the development and validation cohorts. In the development cohort, the risk score model for predicting PEP was established via logistic regression analysis. In the validation cohort, the performance of the model was assessed.In the development cohort, five PEP risk factors that could be identified before ERCP were extracted and assigned weights according to their respective regression coefficients: -2 points for pancreatic calcification, 1 point for female sex, and 2 points for intraductal papillary mucinous neoplasm, a native papilla of Vater, or the pancreatic duct procedures (treated as “planned pancreatic duct procedures” for calculating the score before ERCP). The PEP occurrence rate was 0% among low-risk patients (≤ 0 points), 5.5% among moderate-risk patients (1 to 3 points), and 20.2% among high-risk patients (4 to 7 points). In the validation cohort, the C statistic of the risk score model was 0.71 (95% CI 0.64–0.78), which was considered acceptable. The PEP risk classification (low, moderate, and high) was a significant predictive factor for PEP that was independent of intraprocedural PEP risk factors (precut sphincterotomy and inadvertent pancreatic duct cannulation) (OR 4.2, 95% CI 2.8–6.3;
P
< 0.01).The PEP risk score allows an estimation of the risk of PEP prior to ERCP, regardless of whether the patient has undergone pancreatic duct procedures. This simple risk model, consisting of only five items, may aid in predicting and explaining the risk of PEP before ERCP and in preventing PEP by allowing selection of the appropriate expert endoscopist and useful PEP prophylaxes.
Change point estimation by the mouse medial frontal cortex during probabilistic reward learning
Authors: Murphy Cayla E , Wang Hongli , Ortega Heather K , Kwan Alex C , Atilgan H
Published: December 2024

There are often sudden changes in the state of environment. For a decision maker, accurate prediction and detection of change points are crucial for optimizing performance. Still unclear, however, is whether rodents are simply reactive to reinforcements, or if they can be proactive to estimate future change points during value-based decision making. In this study, we characterize head-fixed mice performing a two-armed bandit task with probabilistic reward reversals. Choice behavior deviates from classic reinforcement learning, but instead suggests a strategy involving belief updating, consistent with the anticipation of change points to exploit the task structure. Excitotoxic lesion and optogenetic inactivation implicate the anterior cingulate and premotor regions of medial frontal cortex. Specifically, over-estimation of hazard rate arises from imbalance across frontal hemispheres during the time window before the choice is made. Collectively, the results demonstrate that mice can capitalize on their knowledge of task regularities, and this estimation of future changes in the environment may be a main computational function of the rodent dorsal medial frontal cortex.
The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)
Authors: Zhang Lingjie , Deng Tong , Liufu Zhongqi , Liu Xueyu , Chen Bingjie , Hu Zheng , Liu Chenli , Tracy Miles E , Lu Xuemei , Wen Hai-Jun , Wu Chung-I
Published: December 2024

Tumorigenesis, like most complex genetic traits, is driven by the joint actions of many mutations. At the nucleotide level, such mutations are cancer-driving nucleotides (CDNs). The full sets of CDNs are necessary, and perhaps even sufficient, for the understanding and treatment of each cancer patient. Currently, only a small fraction of CDNs is known as most mutations accrued in tumors are not drivers. We now develop the theory of CDNs on the basis that cancer evolution is massively repeated in millions of individuals. Hence, any advantageous mutation should recur frequently and, conversely, any mutation that does not is either a passenger or deleterious mutation. In the TCGA cancer database (sample size n=300–1000), point mutations may recur in i out of n patients. This study explores a wide range of mutation characteristics to determine the limit of recurrences (i*) driven solely by neutral evolution. Since no neutral mutation can reach i*=3, all mutations recurring at i≥3 are CDNs. The theory shows the feasibility of identifying almost all CDNs if n increases to 100,000 for each cancer type. At present, only <10% of CDNs have been identified. When the full sets of CDNs are identified, the evolutionary mechanism of tumorigenesis in each case can be known and, importantly, gene targeted therapy will be far more effective in treatment and robust against drug resistance.
Innledning
Authors: Olsen Bjørnar J.
Published: December 2024

Denne utgaven av Ottar tar for seg et særegent arkeologisk fenomen, de såkalte ”mangeromstuftene”. Dette er tufter etter noen svært spesielle hus og bygninger som bare finnes langs kysten av Nord-Troms og Finnmark. Tuftene framstår som klynger av rom forbundet med ganger og passasjer, og er ofte omgitt av en felles ytre voll. De dateres hovedsakelig til perioden 1200-1450.
Smart energy: application of the photovoltaic system using genetic algorithms for decision making in industry 4.0
Authors: Carneiro Adriana Waschington Carneiro de Oliveira , Silva Simone da , Leite Jandecy Cabral , Almeida Anderson Alexandre Silva de , Monteiro Odilon Bentes , Ribeiro Paulo Francisco da Silva , Nascimwento Filho Alarico Gonçalves do
Published: December 2024

The growing demand for sustainable solutions and the digitalization of industrial processes have driven the adoption of photovoltaic systems and advanced decision-making technologies. In the context of Industry 4.0, where automation and artificial intelligence are fundamental, these systems stand out as a clean energy alternative, promoting savings and reducing pollutant emissions. This study aims to develop a photovoltaic energy control model that uses genetic algorithms to optimize energy efficiency in industrial environments, reducing costs and dependence on non-renewable sources. The methodology included the computational modeling of a photovoltaic system and the application of genetic algorithms to optimize parameters such as panel angle and operating hours, adapting the system in real time to variable consumption and generation conditions. The results showed that the use of genetic algorithms increased the system's efficiency by up to 20% compared to traditional methods, as well as minimizing consumption from the electricity grid at peak times. This study reinforces the importance of artificial intelligence in optimizing renewable resources, contributing to energy efficiency and sustainability in Industry 4.0.
Ayurvedic Management of Mukhadushika (Acne Vulgaris): A Case Report
Authors: Khapre Sakshi Yashwant , Wanjari Anita Santoshrao , Naharwal Kirti
Published: December 2024

Acne vulgaris, also known as Mukhadushika; described under Kshudraroga (minor diseases) in Ayurveda is a common skin condition that can have serious psychological and physical effects, especially among adolescents. The present study set out to evaluate the efficacy of Ayurvedic medicines for treating Mukhadushika (Acne vulgaris). A 24-year-old female patient presented with Acne (facial), papules with burning sensation and pain on both cheeks. Her symptoms significantly improved after receiving medicine for both internal and external application. The treatment approach, including the use of Herbo-mineral drugs like Ras manikya, Gandhaka rasayana, Kamdudha Ras, Khadiraristha and Varnya gana lepa. The papules resolved and the discharge, pain and burning sensation disappeared.
Development of a Preliminary Screening Tool for Predicting Polycystic Ovarian Syndrome using Machine Learning and Deep Learning Models with Non Invasive Qualitative Features: A Case-control Study
Authors: Narni Hanumanth , Ananthasetty Vasudeva Rao , Jilani SD
Published: December 2024

Introduction: Polycystic Ovarian Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, characterised by irregular menstrual cycles, hyperandrogenism and polycystic ovaries. Despite its high prevalence, the diagnosis of PCOS remains challenging due to the variability in symptom presentation. Traditional diagnostic methods involve clinical evaluation, biochemical assays and ultrasound imaging. Machine Learning (ML) and Deep Learning (DL) models offer promising avenues for predicting probable cases of PCOS using non invasive qualitative features. Aim: To develop and compare the performance of Random Forest (RF) and Feedforward Neural Network (FFNN) models in predicting PCOS using abundant non invasive qualitative features.

Materials and Methods: A retrospective case-control study was conducted with 100 cases and 100 controls, selected based on ultrasound-confirmed PCOS diagnosis in the Obstetrics and Gynaecology, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology (GVP IHC MT), Medical College departments from February 2024 to October 2024. Data were collected using a structured questionnaire capturing demographic and clinical variables. Feature selection was performed using the Chi-square filter method, with 10 features identified as significant. The data were split into training (80%) and testing (20%) sets and stratified 5-fold cross-validation was applied. Model performance was evaluated using accuracy, precision, recall, F1 score and Area Under Curve (AUC).

Results: The RF model demonstrated high performance on the training set, with an average accuracy of 0.95, but exhibited variability on the testing set (accuracy of 0.80). The FFNN model showed consistent performance across both training (accuracy of 0.80) and testing datasets (accuracy of 0.82). The RF model identified irregular cycles and hirsutism as key predictors, while the FFNN model highlighted weight gain and abnormal Body Mass Index (BMI) as important features. The RF model required significantly less computational time compared to the FFNN model.

Conclusion: The RF model is preferable for tasks requiring computational efficiency, while the FFNN model offers better generalisation. The complementary feature importance rankings suggest that integrating insights from both models could enhance the understanding of PCOS predictors. In epidemiological investigations, these models can be used as preliminary screening tools for identifying probable cases of PCOS using non invasive qualitative features, especially in areas where diagnostic facilities are not available.
Impact of Diabetes on Clinical Characteristics and Angiographic findings in Young Adults with ST-Elevation Myocardial Infarction: A Cross-sectional Study
Authors: Golla Abhishek , Hidayathulla Mohammed , Chavala Sowmya , Gurrala Rajashekar R , Bangi Hussain
Published: December 2024

Introduction: The prevalence of diabetes among young patients with ST-Elevation Myocardial Infarction (STEMI) is increasing, but its impact on this population remains understudied. Limited data on diabetes in young patients with STEMI exist. The presence of diabetes among young patients experiencing STEMI deserves special consideration, as it manifests with unique clinical patterns and can significantly impact their active lifestyle.

Aim: To determine the effect of diabetes and associated clinical characteristics in young patients with STEMI.

Materials and Methods: A cross-sectional study was conducted at a tertiary care centre in India between April 2018 and December 2019. Fifty-one STEMI patients aged below 40 years were enrolled and categorised into diabetic (n=23) and non diabetic (n=28) groups based on glycated haemoglobin (HbA1c) levels. Clinical characteristics, laboratory parameters and angiographic findings were compared between the groups. This study analysed continuous variables using Student’s t-test and Analysis of Variance (ANOVA) (expressed as mean±SD), and categorical variables using Chi-square or Fisher’s exact tests (shown as n, %). A p-value of < 0.05 was considered significant.

Results: The mean age was 35.6±3.4 years, with 80.4% male predominance. Diabetic patients showed higher prevalence of dyslipidaemia (p-value=0.009), hypertension (p-value=0.043), and metabolic syndrome (p-value=0.002). They also exhibited significantly higher levels of total cholesterol, triglycerides and Low-Density Lipoprotein Cholesterol (LDL-C). Anterior Wall Myocardial Infarction (AWMI) was predominant in both groups (p-value=0.442). Single-Vessel Disease (SVD) was most common, but Triple-Vessel Disease (TVD) was observed exclusively in diabetic patients (p-value=0.198). The Left Anterior Descending (LAD) artery was the most involved vessel in both groups.

Conclusion: Compared to non diabetic patients, young STEMI patients with diabetes demonstrated a more adverse cardiovascular risk profile and lipid abnormalities.
Calcium phosphate ceramics having hierarchical pore structure
Authors:   Rzeszów University of Technology, Faculty of Chemistry, Department of Industrial and Materials Chemistry,  6 Powstańców Warszawy Ave., 35 - 959 Rzeszów,  Poland, Potoczek Marek
Published: December 2024

Currently, the most studied materials of porous resorbable ceramics in the field of bone tissue regeneration and as scaffolds in tissue engineering are calcium orthophosphate Ca3(PO4)2 and hydroxyapatite Ca10(PO4)5(OH)2. In this work, calcium orthophosphate ceramic foams were produced by gel-casting of foams method using agarose as a gelling agent. Foaming was carried out at 60°C, followed by the transformation of the foams from the liquid state to the gelled state by cooling them to 15°C. After the sintering process (T = 1100°C, t = 2 h), the basic physical properties of the foam were determined and morphological observations were made using scanning electron microscopy. The foam exhibited a hierarchical pore structure, i.e., spherical macropores with diameters ranging from 250 to 800 µm, interconnections between macropores (so-called “windows”) with diameters in the rage of 30 - 350 µm, and micropores in the ceramic skeleton with diameters ranging from less than 1 to about 3 µm. This structure allows good conditions for bone tissue to grow into the implant.
Environmental Accounting and Performance of Petroleum and Communication Firms in Nigeria (2012-2022)
Authors: G. Chime, Ijeoma , G. N. Ofoegbu, , O. Nnamani, Caroline , M. N. Ozofor, , T. F. I. Nwanne,
Published: December 2024

This study examined the effect of environmental accounting and performance of petroleum and communication firms in Nigeria. It was necessitated by the fact that petroleum and communication firms in Nigeria needs to implement appropriate environmental costs accounting that will help stakeholders in taking economic decision and by extension, create an improvement in the firms' performance.  The broad objective of this study is to investigate the environmental accounting and performance of petroleum and communication firms in Nigeria. Ex- post facto research design was adopted. The population of the study consists of nineteen (19) petroleum and communication firms in Nigeria. Out of the nineteen (19), ten (10) firms were randomly chosen as a sample based on the meeting of requirements of the Nigeria exchange group (NGX). Four (4) Communication firms and six (6) petroleum firms. Time series data were gathered from the annual reports and financial statements of particular petroleum and communication firms. Multiple regression analysis and SPSS Version 26 were used in the analysis. This implied that the null hypothesis was accepted, implying that Community development Cost does not significantly affect return on assets of petroleum and communication firms in Nigeria. The EHSC has a beta coefficient of 100019 and a p-value of 0.3735 which is greater than the significance level at 5%. It means that happy and healthy workforce will lead to increase in productivity and by extension increase financial performance of firms concerned. Based on these results obtained we accept Ho and reject HI. We found that community development cost does not significantly affects Return on Assets of listed petroleum and communication firms in Nigeria; and that a happy and healthy staff would enhance production and, by extension, increase the financial performance of firm concerned. Based on the findings, we recommend, among others, that Nigerian petroleum and communication sectors should invest in community development initiatives to foster positive connections with local community and minimize unemployed youths.
Renewable Energy in India: An Overview and the Path towards Sustainable Development
Authors: Shahdeo Kumar Aditendra Nath , Kumari Shweta
Published: December 2024

The utilization of natural and energy resources began to manifest in the 19th century. Throughout the 20th century, energy usage escalated significantly. Currently, around 80% of global energy consumption is derived from the extraction of fossil fuels, including oil, coal, and gas. Renewable energy has grown increasingly vital as the world confronts the issue of alleviating the adverse effects of climate change and diminishing reliance on finite and polluting fossil fuels. Utilizing renewable energy sources is acknowledged as a crucial element in advancing sustainable development, which seeks to fulfill the requirements of the current generation without jeopardizing future generations. India, akin to other developing nations, is endeavouring to implement various strategies to guarantee a cheap and accessible energy supply for its socioeconomic and political sectors in pursuit of renewable energy advancement. India's Renewable Energy Goals stipulate an objective of attaining 500 GW of installed capacity by 2030. This study aim is to examine the several sources of renewable energy, including solar, wind, hydropower, geothermal, and biomass, to facilitate sustainable development in India. Strong policy support with stable and predictable regulations, effective grid integration strategies to manage variable renewables, dedicated funding for research and development, and strong public engagement are key findings to successfully implement the state-level renewable energy. Setting aggressive renewable energy capacity installation targets, easing grid integration through transmission infrastructure expansion, and offering financial incentives like subsidies and tax benefits are significant recommendations for India to promote renewable energy.
Evaluation of Water Quality of Ogbujilekwe Stream in Njikoka L.G.A of Anambra State
Authors: Sussan Ezenwata Ifeoma , Chibuzo Anyanele Wisdom , Catherine Eze Chinwe , Amaka Egbe Patricia , Chinwe Ezeani Amalachukwu , Anthonia Ezeabara Chinelo , Sylvalyn Anyanele Ijeoma
Published: December 2024

Water pollution is the contamination of waters by bodies by nutrient. These nutrient may be organic or inorganic nutrient Dissolved organic nutrient may serve as a source of living for organisms living in water, and also show detrimental effect on aquatic ecosystem since it, favors bacterial slimes and cause eutrophication. This research work evaluated the water quality of Ogbujilekwe Stream in Njikoka L.G.A. of Anambra State. The parameters used for this evaluation include water color, odour, taste, pH, Oxygen Demand (OD), Biochemical Oxygen Demand (BOD), total dissolved solid, (T.D.S.), turbidity and microbial test.
The result obtained from this research showed that the B.O.D., was high. All the water samples used for the analysis yielded positive result indicating various forms of coliform.
The detection of these coliform in the water samples indicates that stream is seriously being polluted by the animal faces used for planting crops on the watershed. Although the concentrations were within the permissible, range for drinking water, further, inputs accumulation, may result in serious health hazard to the neighbouring communities in Anaocha Local Government Area of Anambra state.
Natural Deep Eutectic Solvents (NADES) Research Framework: Bibliometric Analysis
Authors: Waluyo Eko , Nursyam Happy , Kusuma Bayu , Arini Luthfia Hanun Yuli , Amanda Devi Veda
Published: December 2024

Aims: The Natural Deep Eutectic Solvents (NADES) method is an extraction method currently being developed using affordable green solvents with low cytotoxicity. This research aims to (a) identify developments in NADES research, and (b) develop research gaps for NADES for future research.
Study Design: This research was conducted using bibliometric analysis.
Place and Duration of Study: Library sources refer to research articles available online that can be accessed via websites or search engines by entering specific keywords related to the topic.
Methodology: A research approach using quantitative methods was carried out using bibliometric analysis. Data analysis using bibliometric analysis of “Natural Deep Eutectic Solvents” sourced by article tittle, abstract, and keywords that produced 1,045 Scopus documents.
Results: The results show a growing research trend in NADES, but there are still several gaps that need to be addressed as mentioned in the proposed research framework.
Conclusion: Future research should focus on more comprehensive comparisons, more detailed method explanations, deeper understanding of molecular mechanisms, and long-term stability evaluations to improve the applicability of NADES in various fields. This paper contributes to the development of NADES.
Challenges Faced in the Utilization of FAQs in Agriculture among Farmers in Kerala, India
Authors: Shiney Joe , T Allan , B V Blesson
Published: December 2024

The study aimed to identify and rank the challenges faced by farmers in South Kerala in utilizing Frequently Asked Questions (FAQ) and Frequently Asked Question Solution (FAQ-S) for agricultural information. The research was carried out across five districts, viz., Thiruvananthapuram, Kollam, Alappuzha, Pathanamthitta, and Kottayam, representing diverse agricultural practices. A total of 150 progressive farmers were randomly selected, with 30 participants from each district, based on their active involvement in agricultural programs and knowledge-sharing activities. Primary data were collected through in-person interviews using a pre-tested semi-structured schedule. Challenges were ranked using Garrett’s ranking technique, which provided a comprehensive evaluation of their significance based on both mean scores and Garrett values. The findings revealed that the lack of awareness (mean=72.01 and Garrett value= 80) about FAQ-S ranked as the most critical challenge, followed by time constraints (mean=69.65 and Garrett value= 33 and insufficient trust (mean=54.56 and Garrett value= 40 in the information provided. Other significant barriers included limited content relevance, technical difficulties, language barriers, and access issues. However, despite the agricultural sector's potential, farmers in Kerala, particularly smallholders, face barriers in accessing updated and reliable information essential for improving agricultural productivity. The study concluded that targeted interventions, such as awareness campaigns, trust-building initiatives, localized content development, and improved digital literacy, are essential to enhance the effectiveness of FAQ-S. Based on the findings, it is therefore recommended that if these challenges are properly addressed, it will improve information dissemination, empower farmers, and support sustainable agricultural development in Kerala.
Cybersecurity in the Petroleum Industry: A Comprehensive Review of Threats and Mitigation Strategies
Authors: U.E. Akpan, , O. Okoye.
Published: December 2024

The reliance of the petroleum industry on digital technologies is on the increase. This increase has introduced significant cyber security risks, threatening operations, safety, and the environment. This review examines the current state of cyber security in the petroleum industry, highlighting the range of threats, including phishing, ransom ware, OT-specific risks, like attacks on SCADA and ICS systems, and industrial control system attacks. It also assesses the effectiveness of countermeasures, such as risk assessment, incident response planning, employee training, and advanced security measures like AI and machine learning. The study emphasizes the importance of compliance with industry-specific standards and certification, continuous monitoring, and adaptation to emerging technologies and evolving threats. Some of the cyber security standards and protocols include NIST, ISO/IEC 27001 and CIS. Their duties include provide guidelines to assist organizations in conducting appropriate and effective management and mitigation of risks, establishing a sound information security management system that focuses on safeguarding sensitive data and outline a prioritized method by which one could guard against common cyber threats, putting an emphasis on key areas of security, access control, and response to incidents respectively. This review aims to inform and guide the petroleum industry in strengthening its cyber security posture and ensuring the resilience of its operations as well as this review serves as a guide for leadership on resilience and proactive threat management, addressing critical vulnerabilities.
Determinants of Formal Agricultural Credit Flow to Districts in India: An Econometric Analysis
Authors: HV Harish Kumar , AR Anuja , GP Shivaswamy , Lama Achal , T Rajesh , Singh KN , R Raju
Published: December 2024

Aims: This study investigates the determinants of formal agricultural credit flow at the district level in India, using region-wise fixed effects models.
Study Design: Panel data regression technique.
Place and Duration of Study: Data from districts across Indian states from 2000 to 2021 were analyzed.
Methodology: Districts categorized into high, medium, and low credit exposure groups based on average outstanding agricultural credit by Scheduled Commercial Banks (SCBs) through a clustering technique. One district from each category in each state was selected for analysis. The study examined outstanding agricultural advances by SCBs, the number of SCB branches, gross sown area, gross irrigated area, area under commercial crops, and annual rainfall using an unbalanced panel model.
Results: The findings reveal that an increased number of SCB branches in a district significantly enhances agricultural credit availability. The share of gross irrigated area positively impacts credit flow, especially in the southern, western, and central regions, highlighting the importance of irrigation in accessing credit for high-value crops. In contrast, a higher share of area under commercial crops negatively affects credit flow in the southern and western regions, possibly due to limited financing for rainfed commercial crops. Rainfall was found to have no significant impact on agricultural credit at the district level. Additionally, there is a noticeable trend of increasing urban branches, particularly in the southern, northern, and northeastern regions, alongside a decline in rural branches in most regions except the eastern region.
Conclusion: The study emphasizes the need for targeted policy measures to improve agricultural credit distribution. Policymakers should focus on the number of SCB branches, the share of irrigated area in total sown area, and address the rural-urban branch shift while considering region-specific agricultural requirements to ensure equitable and efficient credit allocation.
Dor Crônica Orofacial e Sofrimento Psíquico: Uma Revisão Narrativa de Literatura
Authors: M. N. Lima Carla , L. Gaspard Jean- , V. Zanotti Susane
Published: December 2024

Orofacial pain (OFP) refers to any type of pain that aff ects the face, mouth, and neck region. When chronic and persistent, managing this condition represents a challenge for healthcare professionals, especially due to the associated psychosocial comorbidities. In this context, psychological factors are often mentioned in healthcare. The objective of this study was to investigate the forms of presentation of the psychological suff ering associated with chronic orofacial pain and the care practices derived from them. A narrative literature review was conducted with a focus on psychological suff ering, from the theoretical-clinical perspective of psychoanalysis. The results were organized into two thematic axes: “Chronic orofacial pain and psychological suff ering” and “Care practices in cases of OFP.” The fi rst comprised the psychological factors associated with OFP and temporomandibular dysfunction (TMD); the ways of measuring suff ering; the COVID-19 pandemic and the worsening of orofacial pain. The second encompassed treatment alternatives through psychotherapy; multiprofessional work; quality of life assessment; and the dimension of listening in pain clinics. The results show that TMD, one of the main causes of OFP, is associated with the incidence of psychological suff ering and impaired quality of life. Studies highlight the need for multiprofessional approaches to accompany cases refractory to traditional treatment of chronic orofacial pain and TMD, but are incipient regarding the clinical approach to suff ering associated with pain.Keywords: Orofacial pain, temporomandibular dysfunction, psychological distress, psychoanalysis, multiprofessional approac
Impact of patient positioning uncertainty in noncoplanar intracranial stereotactic radiotherapy
Authors: Tanaka Yoshihiro , Oita Masataka , Inomata Shinichiro , Fuse Toshiaki , Akino Yuichi , Shimomura Kohei
Published: January 2020

The aim of this study is to evaluate the patient positioning uncertainty in noncoplanar stereotactic radiosurgery or stereotactic radiotherapy (SRS/SRT) for intracranial lesions with the frameless 6D ExacTrac system. In all, 28 patients treated with SRS/SRT of 70 treatment plans at our institution were evaluated in this study. Two X‐ray images with the frameless 6D ExacTrac system were first acquired to correct (XC) and verify (XV) the patient position at a couch angle of 0º. Subsequently, the XC and XV images were also acquired at each planned couch angle for using noncoplanar beams to detect position errors caused by rotating a couch. The translational XC and XV shift values at each couch angle were calculated for each plan. The percentages of the translational XC shift values within 1.0 mm for each planned couch angle for using noncoplanar beams were 77.86%, 72.26%, and 98.47% for the lateral, longitudinal, and vertical directions, respectively. Those within 2.0 mm were 98.22%, 97.96%, and 99.75% for the lateral, longitudinal, and vertical directions, respectively. The maximum absolute values of the translational XC shifts among all planned couch angles for using noncoplanar beams were 2.69, 2.45, and 2.17 mm for the lateral, longitudinal, and vertical directions, respectively. The overall absolute values of the translational XV shifts were less than 1.0 mm for all directions except for one case in the longitudinal direction. The patient position errors were detected after couch rotation for using noncoplanar beams, and they exceeded a planning target volume (PTV) margin of 1.0–2.0 mm used commonly in SRS/SRT treatment. These errors need to be corrected at each planned couch angle, or the PTV margin should be enlarged.
Secukinumab 150/300 mg Provides Sustained Improvements in the Signs and Symptoms of Active Ankylosing Spondylitis: 3‐Year Results from the Phase 3 MEASURE 3 Study
Authors: Pavelka Karel , Kivitz Alan J. , Dokoupilova Eva , Blanco Ricardo , Maradiaga Marco , Tahir Hasan , Wang Yi , Porter Brian O. , Stefanska Anna , Richards Hanno B. , Rohrer Susanne ,   the MEASURE 3 study group
Published: January 2020

Objective

Secukinumab 150 mg has demonstrated significant improvement in signs and symptoms of ankylosing spondylitis (AS), with response rates sustained for up to 5 years. Here, we report end‐of‐study 3‐year efficacy and safety results of secukinumab 150 and 300 mg from the MEASURE 3 study.

Methods

A total of 226 patients was randomized to intravenous secukinumab 10 mg/kg (baseline, weeks 2 and 4) followed by subcutaneous (s.c.) secukinumab 300/150 mg every 4 weeks or a matched placebo. At week 16, placebo patients were re‐randomized to s.c. secukinumab 300/150 mg. Analysis at week 156 included patients initially randomized to secukinumab and those who switched from placebo to secukinumab at week 16 (any secukinumab 300/150 mg). Outcome measures at week 156 included Assessment of Spondyloarthritis International Society (ASAS) 20/40, Bath Ankylosing Spondylitis Disease Activity Index, ASAS partial remission (PR), ASAS 5/6, and Ankylosing Spondylitis Disease Activity Score–C‐reactive protein inactive disease.

Results

The retention rates from weeks 16 to 156 were 80.5% and 80.9% in secukinumab 300 and 150 mg, respectively. ASAS 20/40 response rates at week 156 were 75.0%/56.5% and 68.2%/47.7% for secukinumab 300 and 150 mg, respectively. At week 156, response rates on more stringent clinical end points (eg, ASAS 40, ASAS‐PR) were higher with the 300‐mg dose, particularly in tumor necrosis factor (TNF)–inadequate responder (IR) patients. No new safety findings were observed.

Conclusion

Secukinumab (300 and 150 mg) provided sustained improvements through 3 years in the signs and symptoms of active AS. Improvements with secukinumab 300 mg were numerically higher compared with the 150‐mg dose for some higher hurdle end points and in TNF‐IR patients. The safety profile of secukinumab was consistent with previous reports.
Red AIE‐Active Fluorescent Probes with Tunable Organelle‐Specific Targeting
Authors: Alam Parvej , He Wei , Leung Nelson L. C. , Ma Chao , Kwok Ryan T. K. , Lam Jacky W. Y. , Sung Herman H. Y. , Williams Ian D. , Wong Kam Sing , Tang Ben Zhong
Published: January 2020

Cell staining is a fascinating research area where monitoring and visualizing different cell organelles can be done using fluorescence techniques. However, the design and synthesis of organelle‐targeting fluorophores is still a challenge for several specific organelles. Herein, a platform for synthesizing efficient red‐emitting aggregation‐induced emission luminogens (AIEgens) with donor–acceptor characteristics is reported. The core molecule can be easily functionalized in order to modulate organelle targeting. The three synthesized AIEgens exhibit quantum yields of up to 39.3% and two‐photon absorption cross‐section values of up to 162 GM. The two zwitterionic AIEgens, CDPP‐3SO3 and CDPP‐4SO3, with the sulfonate function group, are successfully utilized for specific one‐photon and two‐photon imaging of the endoplasmic reticulum (ER) in live human cells. Substituting the zwitterionic nature with a singly positive charge group, one‐photon and two‐photon imaging of CDPP‐BzBr shows mitochondrial specificity, indicating the importance of the zwitterionic group for ER‐targeting. Owing to the good in vitro photostability, cell viability, and high efficiency, these red dyes serve as a good potential candidate for specific organelle targeting, as well as illustrate how such a platform can easily aid in the study of structure–property relationships for designing such probes.