bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
Authors: Choi Young Hoon , Lim Younggyun , Jang Dong Kee , Ahn Dong-Won , Ryu Ji Kon , Paik Woo Hyun , Kim Yong-Tae , Kim Ju Han , Lee Sang Hyub
Published: October 2023

Background/Aims: A previous history of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a risk factor for PEP, suggesting that there may be a genetic predisposition to PEP. However, nothing is known about this yet. The aim of this study was to identify genetic variations associated with PEP.Methods: A cohort of high-risk PEP patients was queried from December 2016 to January 2019. For each PEP case, two propensity score-matched controls were selected. Whole exome sequencing was performed using blood samples. Genetic variants reported to be related to pancreatitis were identified. To discover genetic variants that predispose to PEP, a logistic regression analysis with clinical adjustment was performed. Gene-wise analyses were also conducted.Results: Totals of 25 PEP patients and 50 matched controls were enrolled. Among the genetic variants reported to be associated with pancreatitis, only CASR rs1042636 was identified, and it showed no significant difference between the case and control groups. A total of 54,269 non-synonymous variants from 14,313 genes was identified. Logistic regression analysis of these variants showed that the IRF2BP1 rs60158447 GC genotype was significantly associated with the occurrence of PEP (odds ratio 2.248, FDR q value = 0.005). Gene-wise analyses did not show any significant results.Conclusions: This study found that the IRF2BP1 gene variant was significantly associated with PEP. This genetic variant is a highly targeted PEP risk factor candidate and can be used for screening high-risk PEP groups before ERCP through future validation. (ClinicalTrials.gov no. NCT02928718)
(Ré-)invention de soi et revendication identitaire
Authors: Nicolas Jonathan , Goguel d'Allondans Thierry
Published: October 2023

La recherche identitaire de l’adolescent rencontre, dans notre époque actuelle, de nouvelles propositions en termes d’identification. En déliant la question du genre de celle du sexe, les théories du genre ouvrent de nouvelles perspectives d’affirmation individuelle, ouvrant ainsi la binarité « homme/femme », « homosexuel·le/hétérosexuel·le » à d’autres déclinaisons. La possibilité de « choisir son genre » peut alors rencontrer la revendication adolescente d’un « droit à l’autodétermination ».
Semi-supervised graph regularized concept factorization with the class-driven constraint for image representation
Authors: Gao Yuelin , Li Huirong , Zhou Yani , Chen Yijun
Published: October 2023

As a popular dimensionality reduction technique, concept factorization (CF) has been widely applied in image clustering. However, CF fails to extract the intrinsic structure of data space and does not utilize the label information. In this paper, a new semi-supervised graph regularized CF (SGCF) method is proposed, which makes full use of the limited label information and the graph regularization to improve the algorithm of clustering performance. Particularly, SGCF associates the class label information of data points with their new representations by using the class-driven constraint, and this constraint forces the new representations of data points to be more similar within the same class while different between classes. Furthermore, SGCF extracts the geometric structure of the data space by incorporating graph regularization. SGCF not only reveals the geometrical structure of the data space, but also takes into the limited label information account. We drive an efficient multiplicative update algorithm for SGCF to solve the optimization, and analyze the proposed SGCF method in terms of the convergence and computational complexity. Clustering experiments show the effectiveness of the SGCF method in comparison to other state-of-the-art methods.
Local Hölder continuity of inverse variation-inequality problem constructed by non-Newtonian polytropic operators in finance
Authors: Li Jia , Tong Zhipeng
Published: October 2023

This paper aims to explore the inverse variation-inequality problems of a specific type of degenerate parabolic operators in a non-divergence form. These problems have significant implications in financial derivative pricing. The study focuses on analyzing the Hölder continuity of weak solutions by employing cut-off factors.
On the hyperbolicity of Delaunay triangulations
Authors: Carballosa Walter , Rodríguez José M. , Sigarreta José M.
Published: October 2023

If $ X $ is a geodesic metric space and $ x_1, x_2, x_3\in X $, a geodesic triangle $ T = \{x_1, x_2, x_3\} $ is the union of the three geodesics $ [x_1 x_2] $, $ [x_2 x_3] $ and $ [x_3 x_1] $ in $ X $. The space $ X $ is hyperbolic if there exists a constant $ \delta \ge 0 $ such that any side of any geodesic triangle in $ X $ is contained in the $ \delta $-neighborhood of the union of the two other sides. In this paper, we study the hyperbolicity of an important kind of Euclidean graphs called Delaunay triangulations. Furthermore, we characterize the Delaunay triangulations contained in the Euclidean plane that are hyperbolic.
dm-GAN: Distributed multi-latent code inversion enhanced GAN for fast and accurate breast X-ray image automatic generation
Authors: Jiao Jiajia , Xiao Xiao , Li Zhiyu
Published: October 2023

Breast cancer seriously threatens women's physical and mental health. Mammography is one of the most effective methods for breast cancer diagnosis via artificial intelligence algorithms to identify diverse breast masses. The popular intelligent diagnosis methods require a large amount of breast images for training. However, collecting and labeling many breast images manually is extremely time consuming and inefficient. In this paper, we propose a distributed multi-latent code inversion enhanced Generative Adversarial Network (dm-GAN) for fast, accurate and automatic breast image generation. The proposed dm-GAN takes advantage of the generator and discriminator of the GAN framework to achieve automatic image generation. The new generator in dm-GAN adopts a multi-latent code inverse mapping method to simplify the data fitting process of GAN generation and improve the accuracy of image generation, while a multi-discriminator structure is used to enhance the discrimination accuracy. The experimental results show that the proposed dm-GAN can automatically generate breast images with higher accuracy, up to a higher 1.84 dB Peak Signal-to-Noise Ratio (PSNR) and lower 5.61% Fréchet Inception Distance (FID), as well as 1.38x faster generation than the state-of-the-art.
Wear Failure of PEEK-Alumina Ball Bearings in Dry Rolling Contact at 600 rpm - Part 2: Observation of Wear on Retainer
Authors: Matsubayashi Soji , Watanabe Yukinojo , Kida Katsuyuki
Published: October 2023

In our previous paper[6], the effects of the retainer wear failure on the friction torque were investigated. In the present paper, to research the failure of the retainers of the PEEK-alumina ball bearings tested under dry rolling contact, the upper and bottom surfaces and the sections of the retainer pockets were observed. The wear damage was found on the surface of the upper and bottom surfaces. On the sections of the pocket, the changes due to wear at the pocket edge was found. On the worn curves of the sections, large scatter of the curvature center positions were numerically calculated in both specimens. The balls moved relatively for the retainer unit to the upper or bottom sides. These results indicate that the wear changed the pocket shape, and the ball could not become to keep the position for the retainer unit. The wear of the pocket caused the failure of the retainer.
Wear Behaviour of Additive Manufactured Aluminium Alloy ER 5356
Authors: Azlin M. Faris Akmal Md. , Abdullah Ahmad Baharuddin , Nasir Ramdziah Md. , Rajendran R. , Yusuf Shahir Y. Mohd , Hussain Zuhailawati
Published: October 2023

In the automotive industry, parts are mostly made from aluminium alloy due to its lightweight properties and high corrosion resistance. However, the drawback is that the aluminium alloy is easily worn due to wear and friction and will end up in the scrap yard. In order to salvage the aluminium component, the worn part can be repaired. Currently, wire arc additive manufacturing (WAAM) offers flexible remanufacturing of the worn part. However, the wear behaviour of the additively manufactured part needs to be studied first to improve the wear performance of the material. In this study, the gas metal arc welding (GMAW) or MIG-based WAAM machine was utilised to produce a 3D profile from the available aluminium alloy wire grade ER 5356. The wear test was carried out in accordance with ASTM G-99, using a pin-on disc in both dry and wet sliding conditions. It was found that on dry sliding, the specific wear rates are decreasing from 5.3632 x 10-11 mm3/Nm to 4.3496 x 10-11 mm3/Nm and 4.1513 x 10-11 mm3/Nm as the speed increases from 200 to 400 RPM at the constant 20 N load. Meanwhile, for wet sliding, it has been observed that the specific wear rate increases as similar speed values are used in dry sliding conditions, which are 6.8122 x 10-12 mm3/Nm, 1.1931 x 10-11 mm3/Nm and 3.7561 x 10-11 mm3/Nm with a similar constant 20 N load. Next, the coefficient of friction for dry sliding shows that as the speed decreases. In contrast, for wet sliding, it is observed that the coefficient of friction increases.
Tensile Effect on Sensitization and Corrosion Resistance of Stainless Steels
Authors: Ieamsupapong Supat , Taksina Pattarapon , Phakdeemee Thiti
Published: October 2023

The purpose of this research is to investigate cold work effect on corrosion behavior of stainless steels of type AISI 304, AISI 316L and AISI 2101. The specimen were processed through cold work simulated by the tensile test at various percentages elongation and then tempered at 600°C for different time intervals. Two electrochemical techniques and hardness test were utilized in this investigation. The first technique was the double loop electrochemical potentiokinetic reactivation (DL-EPR) that yields the values of degrees of sensitization (DOS). The second one was the cyclic potentiodynamic polarization (CPP) to study the ability of the metals to build or repair the damaged films under localized corrosion. The DOS values from the DL-EPR tests of the samples under the same heating conditions suggested that specimens drawn at higher percentage elongation tend to have more chromium depleted areas. Also, the test specimens with more exposure time to heat were more prone to chromium deficiencies. As for the ability of the metal to create or repair damaged film after corrosion has occurred, it was found that AISI 316L had hihger corrosion resistance than AISI 304. However, AISI 2101 stainless steel had highest corrosion resistance. In this study, it was also found that AISI 2101 did not exhibit pitting corrosion, but the crevice corrosion. This could be due the fact that AISI 2101 which is a duplex stainless steel has high corrosion resistance and could trigger the crevice corrosion take place before the pitting initiation.
Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease
Authors: Foer Dinah , Amin Taneem , Nagai Jun , Tani Yumi , Feng Chunli , Liu Tao , Newcomb Dawn C , Lai Juying , Hayashi Hiroaki , Snyder William E , McGill Alanna , Lin Anabel , Laidlaw Tanya M , Niswender Kevin D , Boyce Joshua A , Cahill Katherine N
Published: October 2023

Platelets are key contributors to allergic asthma and aspirin-exacerbated respiratory disease (AERD), an asthma phenotype involving platelet activation and IL-33–dependent mast cell activation. Human platelets express the glucagon-like peptide-1 receptor (GLP-1R). GLP-1R agonists decrease lung IL-33 release and airway hyperresponsiveness in mouse asthma models. We hypothesized that GLP-1R agonists reduce platelet activation and downstream platelet-mediated airway inflammation in AERD. GLP-1R expression on murine platelets was assessed using flow cytometry. We tested the effect of the GLP-1R agonist liraglutide on lysine-aspirin (Lys-ASA)–induced changes in airway resistance, and platelet-derived mediator release in a murine AERD model. We conducted a prospective cohort study comparing the effect of pretreatment with liraglutide or vehicle on thromboxane receptor agonist-induced in vitro activation of platelets from patients with AERD and nonasthmatic controls. GLP-1R expression was higher on murine platelets than on leukocytes. A single dose of liraglutide inhibited Lys-ASA–induced increases in airway resistance and decreased markers of platelet activation and recruitment to the lung in AERD-like mice. Liraglutide attenuated thromboxane receptor agonist-induced activation as measured by CXCL7 release in plasma from patients with AERD and CD62P expression in platelets from both patients with AERD (n = 31) and nonasthmatic, healthy controls (n = 11). Liraglutide, a Food and Drug Administration–approved GLP-1R agonist for treatment of type 2 diabetes and obesity, attenuates in vivo platelet activation in an AERD murine model and in vitro activation in human platelets in patients with and without AERD. These data advance the GLP-1R axis as a new target for platelet-mediated inflammation warranting further study in asthma.
Coneroichnus marinus ichnogenus et ichnospecies nov., a fossil trackway of marine reptile in the Maiolica Formation (Upper Jurassic–Lower Cretaceous) from Monte Conero, Marche, Italy
Authors: Natali Luca , Leonardi Giuseppe
Published: October 2023

An uncommon ichnofossil, constituted of a sequence of eleven imprints, named as Coneroichnus marinus ichnog. et ichnosp. nov., is described from Mount Conero, Province of Ancona, Italy. The trackway is impressed in whitish micritic limestone of the Maiolica Formation (Upper Jurassic–Lower Cretaceous), herein interpreted as the passage on the sea bottom of a marine reptile, softly interfering in the sediment-water interface. Its gait can be defined as half-swimming, that is the swimming in exploratory and punting propulsive contact with the mud at the bottom. We discuss the probable trackmaker and we suggest it was probably a pliosaurid Plesiosauria. The extreme rarity of ichnofossils of tetrapods on the deep-sea bottom in the whole world is herein confirmed. Keywords: Early Cretaceous, Coneroichnus marinus ichnog. et ichnosp. nov., pelagic reptile trackway.
Mixed marine, brackish water, non-marine, and subaerial microfaunal association in the Red Marls Formation of the Western Aurès Basin (Upper Paleocene)
Authors: Nahnah Raouia , Benmansour Sana
Published: October 2023

In the western part of the Aurès Basin (northeastern Algeria), the Red Marls of El Kantara Formation records a mixed microfaunal association of non-marine-brackish ostracoda, marine foraminifera, lacustrine charophytes, and subaerial Microcodiums. Based on the recovered biotic component, it is considered that the Red Marls of El-Kantara Formation date from the upper Paleocene (Thanetian). Seven species of brackish water (Neocyprideis raoi) and non-marine ostracoda (Frambocythere tumiensis anjarensis, Paracypretta jonesi, Paracypretta verruculosa, Limnocythere deccanensis, Darwinula torpedo and Zonocypris spirula), have been discovered for the first time in Algeria and on the south Tethyan margin. Paleoenvironmentally, the overall biotic assemblage recovered indicates the presence of a freshwater palustrine/lacustrine depositional system connected to a low energy stream/river. This indicates that marginal marine conditions were prevalent in northeastern Algeria’s far inland regions. Paleobiogeographically, the seven known ostracod species have limited distributions that are until now common only with India. However, this disproved the theory that these species are endemic to the Indian Subcontinent, which is confirmed by their association with cosmopolitan charophytes. Keywords: limnic ostracoda, charophytes, paleobiogeography, Thanetian, western Aurès, Algeria.
A new symmoriiform shark and other chondrichthyan teeth from the earliest Permian of southern Brazil
Authors: Pauliv Victor Eduardo , Dias Eliseu Vieira , Sedor Fernando Antonio , Weinschütz Luiz Carlos , Ribeiro Ana Maria
Published: October 2023

The Lontras Shale (Itararé Group, Paraná Basin) is a relevant late Paleozoic fossil stratum in western Gondwana known as a Lagerstätte, as it presents a great diversity that includes plants, invertebrates, ichnofossils and a rich ichthyofauna, mainly composed by exceptionally well-preserved actinopterygians. The chondrichthyan remains reported here are represented by three isolated teeth, collected in dark gray levels of the Lontras Shale from an outcrop known as Campaleo, located in Mafra municipality, northeastern region of the Santa Catarina State, south Brazil. One of these teeth is considered a new genus and species, which represents the first Brazilian Symmoriiformes species known so far, while the other two are attributed to undetermined Chondrichthyes. These chondrichthyans lived alongside brachiopods, poriferans, conodonts, actinopterygians, and crossopterygian fishes in cold waters of a periglacial environment during the earliest Asselian (Cisuralian, Permian) that represents the terminal stage of the Gondwanan Glaciation. Keywords: Cisuralian, Asselian, Paraná Basin, Campo Mourão Formation, Lontras Shale.
Effect of using cassava and glycerol as food storage on the quality of bioplastic packaged food
Authors: Supardi Yosephina Ardiani , Karmini Mimin
Published: October 2023

Food packaging today often involves the migration of monomer substances from petroleum-based plastics into the food. This study aimed to determine the effects of storing food in bioplastic on moisture content and peroxide levels. The study design employed a post-test experimental design with a control group. Dodol samples were selected for this study using a simple random sampling method. The bioplastics used were made from cassava peel starch, and the food storage conditions included temperature-humidity variations of 10-15°C and 85.3-90.8% relative humidity and 25-29°C and 46.5%-80.4% relative humidity. Data were collected through laboratory tests and analyzed using the SPSS program. The study found a significant effect of glycerol dosage on the thickness of the bioplastic (p-value < 0.001). There was a significant influence of temperature-humidity storage on moisture content with glycerol dosages of 3 ml (p-value = 0.002), 4 ml (p-value < 0.023), and 5 ml (p-value = 0.007), as well as on the peroxide content of dodol. This effect was particularly pronounced with glycerol dosages of 3 ml (p-value = 0.001), 4 ml (p-value < 0.001), and 5 ml (p-value = 0.008). The results indicate that cassava peel starch bioplastic can serve as a viable alternative for food packaging, provided that temperature and humidity conditions during food storage are carefully controlled.
A Randomized Comparison between Classical Landmark-based and Ultrasound-guided Right Superficial Cervical Plexus Block in Attenuating Postlaparoscopic Shoulder Pain under Subarachnoid Anesthesia
Authors: Saravanan Balachandar , Chandramohan Thiagarajan , Srinivasan Parthasarathy
Published: October 2023

ABSTRACT

Background:

Postlaparoscopic shoulder pain is believed to be due to phrenic nerve involvement, with an incidence of 35%–80%. Classical landmark-based right superficial cervical plexus block (SCPB) has been utilized to alleviate postlaparoscopic shoulder pain. However, there is no possibility of phrenic nerve blockade with subcutaneously deposited injectate in landmark-based SCPB. Therefore, we hypothesized that the local anesthetic injectate in the sternocleidomastoid-scalene intermuscular fascial plane under ultrasound guidance is paramount in achieving phrenic nerve blockade. The main objective was to evaluate the effect of ultrasound-guided right SCPB in decreasing postlaparoscopic shoulder pain compared to conventional landmark-guided SCPB.

Methods:

In this prospective randomized trial, 79 adult patients reported for laparoscopic surgeries under spinal anesthesia were randomly divided into groups; A and B. Group A patients received intermediate approach to SCPB with 10 ml of 0.5% bupivacaine under ultrasound guidance. Group B patients received SCPB using a classical landmark-based approach. The incidence of intraoperative and postoperative shoulder pain and other adverse effects were noted.

Results:

Intraoperative shoulder pain was significantly less in Group A than in Group B (5% vs. 43.5%, P < 0.001). The postoperative shoulder pain was also significantly reduced in Group A than in Group B (5% vs. 28.2%, P = 0.013). There were no instances of major adverse effects.

Conclusion:

We conclude that the ultrasound-guided injectate in the sternocleidomastoid-scalene intermuscular space deeper to investing layer but superficial to the prevertebral layer of the deep cervical fascia is central to providing superior shoulder pain relief in patients undergoing laparoscopic surgery under spinal anesthesia than the classical landmark-based SCPB.
Thrombocytopenic Purpura in a 40-year-old Patient with Rothia dentocariosa-associated Endocarditis
Authors: Jianjian Song , Heping Jiang , Feifei Li , Kang Gao , Yinghao Gu
Published: October 2023

A 40-year-old male patient with a history of dental disease was sent to the emergency room mainly for fever, unclear consciousness, and purpura. Computed tomography reveals subarachnoid hemorrhage and blood analysis reveals platelet reduction. The patient was started daily intravenous piperacillin tazobactam glucocorticoid and gamma globulin. Two weeks later, symptoms improved but still had severe complications such as fever, platelet reduction, hepatosplenic abscess, and severe myocardial injury. Subsequently, Rothia dentocariosa was cultured from the blood samples of patient’s limb. The patient was started on daily injections of tigecycline and penicillin. Ten days later, symptoms improved and amikacin was tried, which was later confirmed to be ineffective in this patient. Cardiac ultrasound revealed aortic valve vegetations and magnetic resonance imaging revealed brain abscess formation. Then, antibiotics were adjusted to vancomycin and meropenem. Finally, the patient underwent valve replacement. Infectious endocarditis – after surgery, vancomycin and meropenem were utilized for a week leading to symptom resolution. The patient was transferred to rehabilitation hospital. This case will provide clinical experience for the treatment of R. dentocariosa.
The role of remote data capture, wearables, and digital biomarkers in decentralized clinical trials
Authors: Chodankar Deepa , Raval Tapan K. , Jeyaraj Jeyaseelan
Published: October 2023

Decentralized clinical trials (DCTs) are gaining momentum in clinical research as these studies can be executed remotely through telemedicine and mobile/local health-care providers. The COVID-19 pandemic has further accelerated advances and adoption in this area. In the past few years, there has been significant development and growth in the use of remote data that are electronically transmitted from a clinical trial (CT) participant, from outside the clinical setting, to a data repository. Such data may include laboratory data, safety data, or outcome measures reported by the participant, the clinician or the observer. Similarly, wearable health monitoring devices are being increasingly used in health-care and CT settings. Digital biomarkers, which can support continuous measurement of physiologic parameters outside the physical confines of the clinical environment, are also creating new and improved opportunities for patient care and biomedical research, enabling remote monitoring and DCTs. There are several benefits to using remote data capture, wearables, and digital biomarkers in clinical health-care research; however, several questions and challenges still need to be addressed. In an effort to understand the adoption of these technologies in DCTs, and the challenges therein, the authors of this workstream conducted an online survey of clinical research stakeholders across India and reviewed 80 responses. The review article summarizes the key findings from this online survey.
Hepatic Abscess in Inflammatory Bowel Disease: A Systematic Scoping Review of an Overlooked Entity
Authors: Alshammary Shadi Abdullah , Boumarah Dhuha Nahar
Published: October 2023

Background:

Liver abscess is one of the hepatobiliary manifestations of inflammatory bowel disease (IBD) that has been scarcely described in the literature.

Objectives:

To conduct a scoping review to provide a detailed description of the occurrence of hepatic abscess in patients with IBD and summarize the observed clinical features.

Methodology:

Searches were carried out using relevant keywords in Medline (via PubMed) and Web of Science from inception until June 13, 2022. Only articles that reported the occurrence of hepatic abscess in patients with IBD were included.

Results:

Forty-eight publications (40 case reports and 8 case series) were included, representing 73 patients with IBD who were radiologically or intraoperatively diagnosed with hepatic abscess. Patients with Crohn’s disease were more predisposed to developing hepatic abscess than patients with ulcerative colitis (79.5% vs. 20.5%, respectively). Furthermore, pyogenic liver abscess was found to be more prevalent (57.9%) compared with aseptic (38.7%) and amebic (3.2%) abscesses. No clear relation was found between death or prolonged hospital stay in terms of the clinical presentation or management plan, as mortality was reported in different age groups with different managements.

Conclusion:

To date, there is no consensus regarding the appropriate management of hepatic abscess as an extraintestinal manifestation of IBD. However, the condition shares several features with liver abscess diagnosed among the general population.
High Insulin Resistance in Saudi Women with Unexplained Recurrent Pregnancy Loss: A Case–control Study
Authors: Alghamdi Ahlam A. , Alotaibi Amani S.
Published: October 2023

Background:

Unexplained recurrent pregnancy loss (RPL) accounts for >50% of the patients with RPL. Insulin resistance (IR) is a potential cause of unexplained RPL.

Objectives:

To evaluate the relationship between insulin resistance (IR) and unexplained RPL among Saudi women.

Methods:

This is a single-center, case–control study conducted at a tertiary hospital in the Eastern Province of Saudi Arabia. The study group comprised Saudi women with unexplained RPL, while the control group had Saudi women with at least one live birth and no RPL. Blood samples were taken to determine the fasting glucose (FG) and fasting insulin (FI) levels. Women with diabetes mellitus and polycystic ovarian syndrome were excluded. A homeostatic model assessment of insulin resistance index (HOMA-IR) value ≥3 was considered as IR.

Results:

The study and control groups comprised 43 and 56 women, respectively. Between the groups, there was a significant difference in the mean age (case: 37.9 ± 5.4 years; control: 32.2 ± 5.9 years; P < 0.0001) and the mean BMI (case: 31.5 ± 6.0; control: 26.1 ± 2.8; P < 0.0001). FG level was slightly higher in the control group (90.9 mg/dL vs 88.7 mg/dL; P = 0.068). FI level was significantly higher in the study group (16.33 μU/mL vs. 6.17 μU/mL; P < 0.0001). HOMA-IR of ≥3 was significantly more common in the study group (n = 22; 51.2%) than the control group (4; 7.1%) (P < 0.0001). After adjusting for age and BMI, IR ≥3 was found to be independently associated with unexplained RPL (aOR: 13.2; 95% CI: 3.77–46.36).

Conclusions:

This study showed that Saudi women with unexplained RPL had significantly higher levels of fasting insulin and insulin resistance than those without a history of RPL. Therefore, it is recommended to assess IR in women with RPL.
Neural Networks for the Diagnosis of Covid-19 in Chest X-ray Images: A Systematic Review and Meta-Analysis
Authors: Andrade-Girón Daniel Cristobal , Marín-Rodriguez William Joel , Lioo-Jordán Flor de María , Villanueva-Cadenas Gladis Jane , Garivay-Torres de Salinas Flor de María
Published: October 2023

Introduction: The COVID-19 pandemic has triggered a global crisis with significant repercussions in terms of mortality and an ever-increasing demand for urgent medical care, particularly in emergency care settings. This demand arises mainly from the prevailing need to carry out real-time diagnoses and provide immediate care to patients at high risk of serious complications. With the purpose of addressing this problem in a rigorous manner, we have carried out a systematic review focused on evaluating the effectiveness of models based on neural networks for the diagnosis of COVID-19 from chest x-ray images.
Methods: This review has been carried out through an exhaustive search in various renowned electronic bibliographic databases, such as Scopus, IEEE Xplore, PubMed and ScienceDirect. The search period has been extended until September 2023, culminating in the identification of a total of 1,250 relevant articles.
Results: The culminating phase of our review involved the inclusion of 37 studies that met rigorously established selection criteria. These studies have been the subject of a thorough analysis, where various performance metrics such as accuracy/precision, sensitivity/recall, specificity and the F1 value (F1-score) have been evaluated.
Conclusions: Our results reveal that the VGG16 (Visual Geometry Group 16) model, based on neural networks, has emerged as the most widely adopted, manifesting itself in 13.04% of the total models analyzed and in 16.21% of the models supported by the 37 studies. selected. Notably, this algorithm has exhibited an impressive accuracy of over 99% in predicting the diagnosis of patients with suspected COVID-19.
Null controllability and Stackelberg–Nash strategy for a $2\times 2$ system of parabolic equations
Authors: Albuquerque Islanita C. A. , Santos Maurício C.
Published: October 2023

This paper is dedicated to solving a multi-objective control problem for a

2\times2

system of parabolic equations. Here, we have many objectives, possibly conflictive, and we adopt a concept of hierarchy for the controls. We have the leader control, responsible for objectives of controllability type, and the follower controls which intend to be a Nash-equilibrium with respect to some given cost functionals. The novelty here is that we formulate this problem for systems of parabolic equations, meaning that we have many variables and naturally much more objectives to accomplish.
Об одной предельной теореме для ветвящихся случайных блужданий
Authors: Smorodina Natal'ya Vasil'evna , Yarovaya Elena Borisovna
Published: October 2023

Общая теория марковских случайных процессов была заложена А. Н. Колмогоровым. К таким процессам относятся ветвящиеся случайные блуждания по решеткам $\mathbf{Z}^d$, $d\in\mathbf{N}$. Мы рассмотрим ветвящееся случайное блуждание, в котором частицы могут погибать и производить потомство, находясь в любой точке решетки. Перемещение каждой частицы по $\mathbf{Z}^d$ описывается симметричным, однородным и неприводимым случайным блужданием. Интенсивность ветвления частиц в точке $x\in \mathbf{Z}^d$ стремится к нулю при $\|x\|\to\infty$, и выполнено дополнительное условие на параметры ветвящегося случайного блуждания, гарантирующее экспоненциальный по времени рост среднего числа частиц в каждой точке $\mathbf{Z}^d$. В правой части уравнения для среднего числа частиц в этом случае возникает возмущение оператора, задающего блуждание, вызванное возможностью генерации частиц в точке $\mathbf{Z}^d$. Подобного рода уравнения с возмущением оператора диффузии в $\mathbf{R}^2$ были рассмотрены в работе Колмогорова-Петровского-Пискунова в 1937 г. и продолжают исследоваться в теории ветвящихся случайных блужданий на дискретных структурах. В перечисленных выше предположениях доказывается предельная теорема о сходимости в среднеквадратическом нормированного числа частиц в произвольной фиксированной точке решетки при $t\to\infty$.
О полной сходимости моментов в точных асимптотиках при нормальной аппроксимации
Authors: Rozovskii Leonid Victorovich
Published: October 2023

В работе получены новые результаты относительно поведения сумм вида
$$
\overline I_s(\varepsilon) = \sum_{n\geqslant 1} n^{s-r/2}\mathbf{E}|S_n|^r \mathbf I[|S_n|\geqslant \varepsilon n^\gamma],
$$
где $S_n = X_1 +…+ X_n$, $X_n$, $n\geqslant 1$, являются последовательностью независимых одинаково распределенных случайных величин, $s+1 \geqslant 0$, $r\geqslant 0$, $\gamma>1/2$, а $\varepsilon>0$. В качестве примера приведено следующее обобщение пионерского результата Хейди ("A supplement to the strong law of large numbers", J. Appl. Probab., 12 (1975), 173-175): для любого $r\geqslant 0$
$$
\lim_{\varepsilon\searrow 0}\varepsilon^{2}\sum_{n\geqslant 1} n^{-r/2} \mathbf{E}|S_n|^r \mathbf I[|S_n|\geqslant \varepsilon n] =\mathbf{E} |\xi|^{r+2}
$$
тогда и только тогда, когда $\mathbf{E} X=0$ и $\mathbf{E} X^2=1$, а также $\mathbf{E}|X|^{2+r/2}<\infty$, если $r<4$, $\mathbf{E}|X|^r<\infty$, если $r>4$, и $\mathbf{E} X^4 \ln{(1+|X|)}<\infty$, если $r=4$. Здесь $\xi$ обозначает стандартную нормально распределенную случайную величину.
О прямых и обратных уравнениях Колмогорова для чисто скачкообразных марковских процессов и их обобщениях
Authors: Feinberg Eugene Aleksandrovich , Shiryaev Albert Nikolaevich
Published: October 2023

В настоящей статье, приуроченной к 120-летию со дня рождения А. Н. Колмогорова, сначала дается обзор прямых и обратных уравнений Колмогорова для чисто скачкообразных марковских процессов с конечным и счетным множеством состояний, а затем описываются соответствующие результаты для случая марковских процессов со значениями в стандартных борелевских пространствах, основанные на работах В. Феллера и авторов.
Разложение Лапласа для статистики Бартлетта-Нанда-Пиллая и оценка ошибки приближения
Authors: Wakaki Hirofumi , Ulyanov Vladimir Vasilievich
Published: October 2023

Построены асимптотические разложения для функции распределения статистики Бартлетта-Нанда-Пиллая при условии справедливости нулевой линейной гипотезы в многомерной линейной модели. При этом получены вычислимые оценки точности аппроксимации с использованием метода приближения Лапласа, который обобщен на интегралы от матричнозначных функций.
Jerzy Konstanty Czartoryski a „kwestia ruska” w Galicji
Authors: Pijaj Stanisław
Published: October 2023

Jerzy Konstanty Czartoryski and the “Ruthenian question” in Galicia

Jerzy K. Czartoryski was the first member of the Czartoryski family to devote himself to Galicia; he became involved in Galician politics and in the problems of this province of the Habsburg Monarchy. He stood out among the other Polish politicians in Galicia with his attitude to the Ruthenians; he stressed the importance of the Ruthenian question in Galicia, and even believed it to be a “matter of life or death” for the Poles living there. Czartoryski was in favour of Polish-Ruthenian co-operation, recognised the Ruthenians’ national identity, which not all Polish politicians regarded as an obvious thing, and declared his willingness to enter into an agreement with them. He also supported efforts to develop the Ruthenian school system and Ruthenian social and cultural institutions. While recognising and supporting Ruthenian postulates on education, he opposed the political postulates formulated by the Ruthenians at the turn of the nineteenth and twentieth century. His fear of the growing radicalism of the Ruthenian politicians brought him closer to the conservatives, the so-called Podolaks, and later to the National Democrats.
« Ces orgies d’inspirations ». Le destin du peintre d’après le Journal de Félix Ziem
Authors: Sokołowicz Małgorzata
Published: October 2023

“These orgies of inspiration”. The Destiny of the Painter According to the Journal of Félix Ziem

The present paper focuses on the diary of the French painter Félix Ziem (1821-1911) and inquires the destiny of the painter emerging from his writings. Basing on the theories of diary writing (B. Didier, A. Girard, J. Lis), it shows how the artist represents his profession. The analyses convey that three elements are necessary for Félix Ziem to fulfill the destiny of the painter: hard work, dreamy contemplation of nature and travels. Those elements are described in detail in the three consecutive parts of the paper. The conclusions display a self-confident artist, influenced by Romantic aesthetics, who consciously constructs in his diary a testimony of his life as an example of painter’s destiny.
John Ruskin par la voix de Marcel Proust: acheminement vers le moi artiste
Authors: Zgani Mohammed Rida
Published: October 2023

John Ruskin by the voice of Marcel Proust : Journey to the artist’s self The translation of La Bible d’Amiens and Sesame et les Lys was a way for Proust to take an interest in religious art, but also to cultivate his own vision of art. Ruskin was for Proust a guide who participated in the support of his artistic self by transfering a certain number of aesthetic conceptions to which his mind would never have been able to access on its own. Proust succeeds in recognizing the decisive dimension of the Christian religion and its implications for Ruskin's aesthetics. Transcending the religious dimension, Proust realizes that Christian architecture, as understood by Ruskin, acquires a meaning other than religious, namely that of a past sublimated by the powers of art. Thus the historical dimension is annihilated in favor of an aesthetic perception of works from the past. Our article therefore aims to show how this experience of translation allowed Proust to deconstruct the aesthetic vision of the author of the translated text, while constructing a vision of art that is his own.
L’An deux mille quatre cent quarante – voyage imaginaire dans le temps selon le schéma canonique
Authors: Świtlik Stanisław
Published: October 2023

The Year 2440: A Dream If Ever There Was One

The aim of this paper is to comment the links between the work of Louis-Sébastien Mercier, The Year 2440: A Dream If Ever The Was One, and narrative utopia model. The Mercier’s work is often considered as inventive fiction which presents a new type of utopia focused on the future, but a large number of traditional narrative strategies is used by the author to show Paris in 25th century. The future civilization is built on the Enlightenment ideas but it remains still attached by its culture to the 18th century. The Mercier’s work is inspired by the utopism but in this fiction the reader finds more a fictional realization of dreams and philosophical thinking about human nature.
Autour des congrès des écrivains et artistes noirs et des festivals panafricains – entretien avec Sarah Frioux-Salgas
Authors: Obszyński Michał
Published: October 2023

Black Writers’ and Artists’ Congresses and Pan-African Festivals - values and issues of intellectual debates and artistic events from the 1950s to today - interview with Sarah Frioux-Salgas

Focusing on the major intellectual debates surrounding the Black and African Renaissance, the interview with Sarah Frioux-Salgas, head of archives and collections’ resources at the Musée du quai Branly-Jacques Chirac media library, covers topics such as the role of Black writers’ and artists’ congresses and art festivals in the cultural reaffirmation of Black people during the decolonization era of the 1950s-60s, the place of literature in the shaping of Black pan-African and transcontinental solidarity, the figure of the Black intellectual, particularly that of Léopold Sédar Senghor, and the networks of ideological affinities and antagonisms formed by Black writers, artists and activists. The interview aims to highlight the complexity of the socio-political and aesthetic issues at stake, all too often summed up in simplified definitions of projects such as negritude or Pan-Africanism.
Ponticulus posticus: prevalência e associação com manifestações clínicas em população brasileira
Authors: Felipe Beatriz Caio , Silva Pedro Henrique Castelão , Ferreira Matheus Herreira , Silva Breno Gabriel da , Chicora Paula Gabriela Vieira , Tolentino Elen de Souza , Iwaki Lilian Cristina Vessoni , Chicarelli da Silva Mariliani
Published: October 2023

Ponticulus posticus (PP) é uma variação anatômica caracterizada por ser uma ponte óssea entre a parte posterior do processo articular superior e a parte posterolateral do arco posterior da vértebra Atlas (C1). Essa variação pode estar associada à sintomatologia dolorosa. Este estudo visa a contribuir com mais dados a respeito do PP, investigando sua prevalência e utilizando tomografias computadorizadas de feixe cônico (TCFC) realizadas em população brasileira, correlacionando sexo, idade e, principalmente, manifestações clínicas. Foram analisados 673 TCFC de pacientes brasileiros, em que 167 (24,81%) exames analisados apresentaram o PP. A presença e o tipo de PP foram avaliados e categorizados como parciais ou completos, unilateral ou bilateral. A relação da presença do PP com a sintomatologia foi feita por meio de um questionário. No total 39 (23,35%) indivíduos participaram da pesquisa quanto à etapa de coleta de informações a respeito da presença ou da ausência de sintomatologia que pudesse ser relacionada à presença do PP, sendo 23 (58,98%) do sexo feminino e 16 (41,02%) do sexo masculino. Em 11 (28.20%) pacientes, verificou-se estrutura anatômica parcialmente no lado esquerdo, enquanto oito (20,51%) apresentaram a estrutura anatômica parcialmente no lado direito. No que diz respeito à presença bilateral, nove (23,07%) pacientes a apresentaram. Não houve associação de nenhuma sintomatologia com os tipos de classificação dos PP (valor-p > 0,05) e nem relação estatística entre sexo e idade. Assim, foi possível concluir que inexiste correlação comprovada entre a presença do PP e a presença de manifestações clínicas.
Systematic Review: Trends in Intelligent Tutoring Systems in Mathematics Teaching and Learning
Authors: Niño-Rojas Francisco , Lancheros-Cuesta Diana , Jiménez-Valderrama Martha Tatiana Pamela , Mestre Gelys , Gómez Sergio
Published: October 2023

The use of intelligent tutoring systems (ITSs) is growing rapidly in the field of education. In mathematics, adaptive and personalized scenarios mediated by these systems have been implemented to aid concept comprehension and skill development. This study presents a systematic review on the current status of the use of ITSs in mathematics education in higher education institutions (HEI). More specifically, it inquires about elements rarely addressed in reviews, such as the purposes, advantages, effectiveness, limitations, characteristics, and development and research methodologies in ITSs used for mathematics education. We analyzed 43 documents in 15 specialized and indexed journals in the years 2012-2022. In addition to providing a global overview of the implementation of ITSs in mathematics teaching and learning, we also present trends and opportunities for future research on building educational environments guided by these technologies.
The Effects of Technical Skills, Attitudes, and Knowledge on Students' Readiness to Use 4.0 Industrial Revolution Technologies in Education
Authors: Alshammari Sultan Hammad
Published: October 2023

Technological advancements have led to the emergence of the Fourth Industrial Revolution (4IR). Students’ readiness to use 4IR technologies is thus essential for the development of knowledgeable, competent, and skilled graduates. However, ensuring students’ readiness to use 4IR technologies is quite challenging, leading to a need to understand the factors that influence readiness in this regard. In this study, a research model was developed for examining effects of students’ technical skills, attitudes, and knowledge on their readiness to use 4IR technologies. Data were collected from 182 students through an online survey. A two-step data analysis was then performed using AMOS. A confirmatory factor analysis was conducted to assess the research model, and SEM was then applied to examine the hypotheses and relationships between the constructs. The results demonstrated that students’ technical skills, attitudes, and knowledge levels significantly influenced their readiness to use 4IR technologies. Recommendations for policy and decision makers in higher education were drawn from this research to increase students’ readiness for adopting and using 4IR technologies.
Integrating Digital Storytelling into STEAM Teaching: Examining Young Language Learners’ Development of Self-regulation and English Literacy
Authors: Amirinejad Maryam , Rahimi Mehrak
Published: October 2023

As an innovative pedagogical approach, STEAM Education uses science, technology, engineering, the arts, and mathematics to spark students’ learning motivation, problem-solving skills, and cognitive development. Despite widespread literature on STEAM pedagogy, evidence on the benefit of integrating STEAM with technology-enhanced language learning at elementary levels is insufficient. This study thus inspects the impact of incorporating digital storytelling (DST) into STEAM teaching on young language learners' development of self-regulation and English literacy. Thirty-three schoolchildren participated in the study as the experimental and control groups. Their English literacy and self-regulation were examined before and after the study. Both groups received STEAM instructional content in English for one semester. The DST group worked with the online platform StoryJumper to make digital books for their projects; meanwhile, the control group prepared their projects by reports and presentations. At the end of the experiment, the DST group’s academic self-regulation improved significantly which was the result of their enhanced introjected and external regulation. Also, the DST group outperformed the control group in English literacy. Due to the key role of STEAM education in making students interested in STEAM disciplines at elementary levels, planning and implementing best practices of STEAM pedagogy for schoolchildren is recommended.
An Examination of the Attitudes of Teacher Candidates towards Mobile Learning
Authors: Kirbas Abdulkadir , Bulut Mesut
Published: October 2023

This study aims to ascertain how potential Turkish language and literature and Turkish teacher candidates tend to mobile learning. In this context, it investigates whether there are any notable differences in these aspiring teachers' attitudes toward mobile learning based on elements like gender, age, major field of study, grade level, personal tablet ownership, computer ownership, income level, social media usage, and enrollment in computer courses. A relational survey model, a quantitative research method, is used in this study.  209 females and 65 males who willingly joined the study at a university in Turkey's east comprise its participant pool. The findings reveal that prospective teachers of Turkish language and literature, as well as Turkish language teaching, strongly endorse the statements in the Mobile Learning Attitude Scale. Furthermore, their attitudes towards mobile learning do not exhibit significant variations concerning variables such as gender, major field of study, grade level, personal tablet ownership, possession of a computer, income level, social media usage, and participation in a computer course. Nevertheless, a noteworthy difference is identified in attitudes towards mobile learning across different age groups. The outcomes imply that while substantial distinctions exist among age groups, the attitudes of prospective teachers in the aforementioned fields do not significantly differ in terms of demographic or technological aspects. These results underscore the importance of integrating mobile learning into teaching and learning. Encouraging positive attitudes towards mobile learning and conducting additional research on this subject are strongly recommended.