bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of the Human Gut Microbiota between Normal Control Subjects and Patients with Colonic Polyps and Colorectal Cancer
Authors: Uppakarn Kittipot , Bangpanwimon Khotchawan , Hongpattarakere Tipparat , Wanitsuwan Worrawit
Published: December 2021

Background: The human gut microbiota has been related to numerous colonic diseases. To identify colorectal cancer (CRC)-associated microbiota, the gut microbiomes of patients with colonic polyps and CRC compared to normal controls were analyzed.Methods: Between July and December 2020, forty-four stool samples were obtained from participants older than 50 years who were scheduled for elective colonoscopies at the Surgery Clinic, Songklanagarind Hospital. The samples were divided into 3 groups (17 normal control, 17 colonic polyps, and 10 CRC) and were collected for analysis with a 16s metagenomic sequencing library preparation with MiSeq Reporter software (MSR) following the protocol of the 16s metagenomics workflow. The microbiome data were analyzed with Kruskal–Wallis test with the Dunn-Bonferroni post hoc method.Results: The relative proportions of beneficial butyrate-producers Kineothrix alysoides, Eubacterium rectale, and Roseburia inulinsivorans were significantly higher in healthy control and colonic polyp groups compared with the CRC group at the top three lowest p-values. The recommended CRC biomarker Clostridium symbiosum was shown in a significantly higher proportion in the CRC group than in the normal control group. The prevalences and relative proportion of the novel CRC-associated species Acutalibacter muris and the familiar CRC-associated species Christensenella massiliensis and lntestinimonas butyriciproducens were significantly higher in the CRC group than in the normal control and colonic polyp groups at the top three lowest p-values.Conclusions: A correlation between specific bacteria and clinical outcomes was found in this pilot study. The microbiome data revealed possible microbial biomarkers associated with CRC. Studies with larger numbers of stool samples are required to substantiate our findings.
Divergent Actions of Pyruvate and ATP in Glucose-mediated Irinotecan Chemoresistance in Colorectal Cancer
Authors: Huang Chung-Yen , Pai Yu-Chen , Yu Linda Chia-Hui
Published: December 2021

Background: Altered glucose metabolism is associated with chemoresistance in colorectal cancer (CRC). The aim of this study was to illustrate the molecular mechanisms of glucose-mediated chemoresistance against irinotecan, a topoisomerase I inhibitor, focusing on the distinct roles of metabolites such as pyruvate and ATP in modulating cell death and proliferation. Methods: Four human CRC cell lines, tumorspheres, and mouse xenograft models were treated with various doses of irinotecan in the presence of high concentrations of glucose, pyruvate or ATP-encapsulated liposomes. Cell apoptosis was measured by DNA fragmentation and caspase activities, and necroptosis was evaluated by immunoprecipitation of receptor-interacting protein kinase (RIP) 1/3 complex. Cell cycles were assessed by flow cytometric analysis.Results: Human CRC cell lines treated with irinotecan in the presence of high glucose displayed increased cell viability and larger xenograft tumor sizes in mouse models compared to those treated in the presence of normal glucose. Irinotecan induced apoptosis and necroptosis, both of which were mitigated by high glucose. Liposomal ATP prevented irinotecan-induced apoptosis, while it had no effect on necroptosis. In contrast, pyruvate attenuated the RIP1/3-dependent necroptosis via free radical scavenging, without modulating apoptotic levels. Regarding the cell cycle, liposomal ATP aggravated irinotecan-induced G0/G1 shift whereas pyruvate diminished the G0/G1 shift, showing opposite effects on proliferation. Last, tumorsphere structural damage, an index of solid tumor responsiveness to chemotherapy, was determined. Liposomal ATP increased tumorsphere sizes while pyruvate prevented the deformation of spheroid mass. Conclusions: Glucose metabolites confer tumor chemoresistance via multiple modes of action. Glycolytic pyruvate attenuated irinotecan-induced necroptosis and potentiated drug insensitivity by shifting cells from a proliferative to quiescent state. On the other hand, ATP decreased irinotecan-induced apoptosis and promoted active cell proliferation, which might contribute to tumor recurrence.
Out of Hospital Cardiac Arrest (OHCA): Experience of a Bystander CPR Training Program in Karachi, Pakistan
Authors: Khan Uzma Rahim , Khudadad Umerdad , Baig Noor , Ahmed Fareed , Raheem Ahmed , Hisam Butool , Khan Nadeem Ullah , Hock Marcus Ong Eng , Razzak Junaid Abdul
Published: December 2021

Background: Nearly 90% of out-of-hospital cardiac arrest (OHCA) patients are witnessed, yet only 2.3% received bystander CPR (cardiopulmonary resuscitation in Pakistan. This study aimed to determine retention of knowledge and skills of Hands-Only CPR among community participants in early recognition of OHCA and initiation of CPR in Karachi, Pakistan.Methods: The pre and post-tests were conducted among participants from diverse non-health-related backgrounds from July 2018 to October 2019. Participants were tested for knowledge and skills of CPR before training (pre-test), immediately after training (post-test), and six months after training (retention test). All the participants received CPR training through video and scenario-based demonstration using manikins. Post-training CPR skills of the participants were assessed using a pre-defined performance checklist. The evaluator read out numerous case scenarios to the participants, such as drowning, poisoning, and road traffic injuries, etc., and then asked them to perform the critical steps of CPR identified in the scenario on manikins. The primary outcome was the mean difference in the knowledge score and skills of the participants related to the recognition of OHCA and initiation of CPR. Results: The pre and post-tests were completed by 722 participants, whereas the retention test after 6 months was completed by 358 participants. The mean knowledge score related to the recognition of OHCA, and initiation of CPR improved significantly (p <0.001) from pre-test (47.2/100, ±13.2) to post-test (69.9/100, ±12). The mean CPR knowledge after six months (retention) reduced slightly from (69.9/100, ±12) to (64.8/100, ±9.3). The CPR skill retention for various components (correct placement of the heel of hands, complete chest recoil, check for scene safety, check for a response, and activate emergency response system) slightly deteriorated from 79% in the post-test to 72% in re-test. However, participants performed slightly better on achieving an adequate rate of chest compressions from 73.7% in post-test to 75.5% in re-test.Conclusion: Community members with non-health backgrounds can learn and retain CPR skills, allowing them to be effective bystander CPR providers in OHCA situations. We recommend training the mass population in Pakistan regarding CPR to increase the survival rate from OHCA.
Uncertainty-aware Visual Analytics - Scope, Oppertunities and Challenges
Authors: Maack Robin Georg Claus , Scheuermann Gerik , Hagen Hans , Peñaloza Jose Tiberio Hernández , Gillmann Christina
Published: December 2021

In many applications, Visual Analytics(VA) has developed into a standard tool to ease data access and knowledge generation. Unfortunately, many data sources, used in the VA process, are affected by uncertainty. In addition, the VA cycle itself can introduce uncertainty to the knowledge generation process. The classic VA cycle does not provide a mechanism to handle these sources of uncertainty. In this manuscript, we aim to provide an extended VA cycle that is capable of handling uncertainty by quantification, propagation, and visualization. Different data types and application scenarios that can be handled by such a cycle, examples, and a list of open challenges in the area of uncertainty-aware VA are provided.
A Foliar Pigment-Based Bioassay for Interrogating Chloroplast Signalling Reveals that Chlorophyll Biosynthesis Requires Carotenoid Isomerisation.
Authors: Dhami Namraj , Pogson Barry J , Tissue David T , Cazzonelli Christopher I
Published: December 2021

Background: Plastid-derived metabolites can signal control over nuclear gene expression, chloroplast biogenesis, and chlorophyll biosynthesis. Norflurazon (NFZ) inhibition of carotenoid biosynthesis in seedlings can elicit a protoporphyrin retrograde signal that controls chlorophyll and chloroplast biogenesis. Recent evidence reveals that plastid development can be regulated by carotenoid cleavage products called apocarotenoids. The key steps in carotenoid biosynthesis and catabolism that generate apocarotenoid signalling metabolites in foliar tissues remains to be elucidated. Here, we established an Arabidopsis foliar pigment-based bioassay using detached rosettes to differentiate plastid signalling processes in young expanding leaves containing dividing cells with active chloroplast biogenesis, from fully expanded leaves containing mature chloroplasts. Results: We demonstrate that environmental (extended darkness and cold exposure) as well as chemical (norflurazon; NFZ) inhibition of carotenoid biosynthesis can reduce chlorophyll levels in young, but not older leaves following a 24 h of rosette treatment. Mutants that disrupted xanthophyll accumulation, phytohormone biosynthesis (abscisic acid and strigolactone), or enzymatic carotenoid cleavage, did not alter chlorophyll levels in young or old leaves. Perturbations in acyclic cis-carotene biosynthesis revealed that disruption of CAROTENOID ISOMERASE (CRTISO), but not ZETA-CAROTENE ISOMERASE (Z-ISO) activity, reduced chlorophyll levels in young but not older leaves of plants growing under a long photoperiod. NFZ-induced inhibition of PHYTOENE DESATURASE (PDS) activity triggered phytoene accumulation more so in younger relative to older leaves from both WT and the crtiso mutant, indicating a continued substrate supply from the methylerythritol 4-phosphate (MEP) pathway for carotenogenesis. NFZ treatment of WT and crtiso mutant rosettes reveal similar, additive, and opposite effects on individual pigment accumulation.Conclusion: The Arabidopsis foliar pigment-based bioassay was used to differentiate signalling events elicited by environmental, chemical, genetic, and combinations thereof, that control chlorophyll biosynthesis. Genetic perturbations that impaired xanthophyll biosynthesis and/or carotenoid catabolism did not affect chlorophyll biosynthesis. The lack of CAROTENOID ISOMERISATION generated a signal that rate-limited chlorophyll accumulation, but not phytoene biosynthesis in young Arabidopsis leaves exposed to a long photoperiod. Findings generated using this new foliar pigment bioassay implicate that carotenoid isomerisation and NFZ elicit different signalling pathways to control chlorophyll homeostasis in young emerging leaves.
An Initial-Controlled Double-Scroll Hyperchaotic Map
Authors: Li Yongxin , Li Chunbiao , Liu Sicong , Lei Tengfei , Jiang Yicheng
Published: December 2021

Initial condition-dominated offset boosting provides a special channel to arrange coexisting orbits. Due to the nonlinearity and inherent periodicity, sinusoidal function is often introduced into a dynamical system for multistability design. In this paper, an initial-controlled double-scroll hyperchaotic map is constructed based on two sine functions. Four patterns of the double-scroll hyperchaotic orbits are found as 0-degree, 90-degree, 45-degree and 135-degree. Consequently, different modes for attractor growing are demonstrated. Finally, hardware experiments based on STM32 are carried out to verify the theoretical analysis and numerical simulation.
Outcomes of Side to End versus End to End Colorectal Anastomosis in Non-emergent Sigmoid and Rectal Cancers. Randomized Controlled Clinical Trial.
Authors: Tamer.A.A.M.Habeeb  , Mohammad Hatem , TamerWasefy  , Mansour Mohamed Ibrahim
Published: December 2021

Purpose

The outcomes of open side-to-end colorectal anastomosis versus open end to end colorectal anastomosis in non-emergent sigmoid and rectal cancers open surgery in adults were compared.
Methods

A randomized controlled trial on individuals with sigmoid and rectal cancers was conducted between September 2016 and September 2018.
Results

The majority of the participants in the study were between the ages of 50 and 70 years, with a mean age of 62.58±12.3 years in the side-to-end anastomotic group (SEA group = group A = antegrade approach) and 61.03±13.98 years in the end-to-end anastomotic group (EEA group = group B = retrograde approach), respectively. Except for the operative time, intraoperative data revealed no significant differences between the studied groups, and the SEA group revealed that the mean anastomotic time was significantly shorter. Perioperative blood loss, length of stay, reoperation, inpatient death, infection, and bleeding were all revealed to be significantly associated with leakage in univariate analysis. In a multivariate analysis of anastomotic leaks, infection was the only independent predictor. There is a statistically significant change regarding the range of bowel frequency in the EEA group only (p = 0.04). There is a statistically significant difference regarding incontinence for Flatus in the SEA group only (p = 0.00). A statistically significant change in both groups regards incontinence for liquid stools (p = 0.00) and clustering of stools (p = 0.00 and p = 0.043). The quality of life (QOL) in the SEA group significantly dropped at 6 months and returned to baseline after that as regards PWB, FWB, and CCS with no difference as regards SWB & EWB, while in the EEA group, the exact change happened only as regard PWB & FWB, but SWB and CCS percentage did not return to baseline.
Conclusion

The SEA group offers a safe and approach alternative to the EEA group.
Camel-related Major Vascular Injuries: A 20-years’ Experience
Authors: Abu-Zidan Fikri M. , Abdel-Kader Saleh , Mousa Hussam , Aiyan Ahmad Al , Baguneid Mohamed S. , Jawas Ali
Published: December 2021

Background: Majority of animal-related injuries in United Arab Emirates are caused by camels. We aimed to study the anatomy, biomechanism and outcome of major camel-related human vascular injuries and correlate them to the camel anatomy and behavior.Methods: We retrospectively studied all patients who were admitted to Al-Ain Hospital with camel-related major vascular injury during January 2001 to January 2020. A special protocol was designed to collect the data. An adult 7-year-old male camel skull was prepared and web-based video clips of camel bites to humans were analysed to have an in-depth understanding of the biomechanism of injury.Results: Seven patients were studied, all were males having a median age of 26 years. Five out of six bite injuries (83%) occured during the camel rutting season. The injuries were severe and life threatening. Four involved the carotid artery, one the femoral artery and vein, one the external iliac vein and one the aorta which was due to a fall from a camel. Although the standard of surgical care was high, the outcome was poor. Six patients were admitted to the ICU for a median of 5 days. One patient died, one was vegetative, and one had arm paralysis. The elongated jaws of the camel having its biting component at the front, and the strong masseter muscles at the back increases the strength of its bite grip. Each bite causes four small elliptical wounds of the canine teeth which resembles two stab wounds of 8 cm long, penetrating deeply and injuring major vessels. Aggressive camels bite repeatedly to kill their victims.Conclusions: Camel-related vascular injuries have a poor clinical outcome. Although the basis of their surgical management is similar to other vascular injuries, their poor outcome is related to the aggressiveness of the attacking camel, the anatomy of its jaw, and its intention to kill. Neck wounds of camel bites can be closed primarily after debridement. Studying these unusual injuries gives an insight into the “one globe one health approach” in which humans interacts with the animals and the environment around them. It important to understand the camel behavior for injury prevention.
Human Blood-Derived Lymphoblastoid Cybrids for Assessment of Mitochondrial tRNAs Deficiency by MTO1 Silence
Authors: Chen Chao , Wang Qi , Aishanjiang Maerhaba , Wei Yuping , Gao Zewen , Chen Ye , Lei Zhixian , Ye Shixin
Published: December 2021

Background: Mutations in the mitochondrial translation optimization 1 (MTO1) gene can cause hypertrophic cardiomyopathy. Although the functional role of MTO1 deficiency in certain cells is gradually confirmed, the phenotype of MTO1 deficiency in a lymphoblastoid cybrid line is not yet reported. In this study, we characterized changes of mitochondrial function in MTO1 silenced cybrid cells derived from human lymphoblastoids, immature white blood cells that give rise to lymphocytes. Results: We showed that MTO1 silence decreased the levels of 2-thiourylation of mitochondrial tRNALys, tRNAGlu, and tRNAGln, nevertheless, the aminoacylation efficiency of tRNALys and the steady state of mitochondrial tRNAs were elevated. These aberrant tRNA changes caused a significant decrease in protein levels of oxidative phosphorylation complex subunits including complex I, III, IV and V. Furthermore, dysfunctional mitochondria promoted apoptosis in stress, evidenced by elevated ratios of apoptotic cells and increased levels of apoptosis-activated proteins in the MTO1 knockdown cell lines, as compared to the controls. Conclusions: Our data provide new insights into the important functional role of MTO1 in lymphoblastoid mitochondria. We envision the cybrid cell line approach we have established provides an alternative model for the cardiac tissue of high-energy demands characteristics, and they hold promises for the diagnosis and drug screening for the therapeutic agents of hypertrophic cardiomyopathy caused by MTO1 dysfunction.
SNP-based Genetic Structure of Tunisian Durum Wheat Landraces and Distribution of the Resistance to Septoria Tritici Blotch
Authors: Ouaja Maroua , Bahri Bochra , Ferjaoui Sahbi , Medini Maher , Sripa Udupa . , Hamza Sonia
Published: December 2021

Background: Septoria tritici blotch (STB) has marked durum wheat production worldwide. This fungal disease is until today a challenge for farmers, researchers and breeders all united in the aim of reducing its damage and improving wheat resistance. Tunisian durum wheat landraces were reported to be valuable genetic resources for resistance to biotic and abiotic stresses and are therefore prominently deployed in breeding programs to develop new varieties adapted to fungal diseases as STB and to climate change constraints overall.Results: A total of 366 local durum wheat accessions were assessed for resistance to two virulent Tunisian isolates of Zymoseptoria tritici Tun06 and TM220 under field conditions. Population structure analysis of the durum wheat accessions, performed with 286 polymorphic SNPs (PIC >0.3) covering the entire genome, identified three genetic subpopulations (GS1, GS2 and GS3) with 22% of admixed genotypes. Interestingly, all of the resistant genotypes were among GS2 or admixed with GS2. Conclusions: This study revealed the population structure and the genetic distribution of the resistance to Z. tritici in the Tunisian durum wheat landraces. The grouping pattern of accessions appear to be associated, to some extent, with the geographical pattern of the landraces. We suggested that GS2 accessions were mostly introduced from eastern Mediterranean populations, unlike GS1 and GS3 that originated from the west. Resistant GS2 accessions belonged to landraces Taganrog, Sbei glabre, Richi, Mekki, Badri, Jneh Khotifa and Azizi. Furthermore, we suggested that admixture contributed to transmit STB resistance from GS2 resistant landraces to initially susceptible landraces such as Mahmoudi (GS1), but also resulted in the loss of resistance in the case of GS2 suscpetible Azizi and Jneh Khotifa accessions.
Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database
Authors: wu jinbo , Hu Taobo , wang shu
Published: December 2021

Background
Breast cancer has remained the most common malignancy in women over the past two decades. As lifestyle and living environments have changed, alterations to the disease spectrum have inevitably occurred in this time. As molecular profiling has become a routine diagnostic and objective indicator of breast cancer etiology, we analyzed changes in gene expression in breast cancer populations over two decades using The Cancer Genome Atlas (TCGA).
Methods
We performed Heatmap and Venn diagram analyses to identify constantly up- and down-regulated genes in this cohort. We used Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses to visualize associated functional pathways.
Results
We determined that three oncogenes, PD-L2, ETV5, and MTOR and 113 long intergenic non-coding RNAs (lincRNAs) were constantly up-regulated, whereas two oncogenes, BCR and GTF2I, one tumor suppression gene (TSG) MEN1, and 30 lincRNAs were constantly down-regulated. Up-regulated genes were enriched in “focal adhesion” and “PI3K-Akt signaling” pathways, et al, and down-regulated genes were significantly enriched in “metabolic pathways” and “viral myocarditis”. Eight up-regulated genes exhibited doubled or higher expression, and the expression of three down-regulated genes was halved or lowered and correlated with long-term survival.
Conclusions
In this study, we determined that genes and molecular pathways are constantly changing, importantly, some altered genes were associated with prognostics and are potential therapeutic targets, suggesting molecular typing technologies must keep pace with this dynamic situation.
Association of ACE2 Polymorphisms and Derived Haplotypes with Obesity and Hyperlipidemia in Female Spanish Adolescents
Authors: Lumpuy-Castillo J. , Vales-Villamarín C. , Mahíllo-Fernández I. , Pérez-Nadador I. , Soriano-Guillén L. , Lorenzo Oscar , Garcés C.
Published: December 2021

Background
In the cardiovascular (CV) system, overactivation of the angiotensin converting enzyme (ACE) may trigger deleterious responses derived from angiotensin (Ang)-II, which can be attenuated by stimulation of ACE2 and subsequent Ang-(1-7) metabolite. However, ACE2 exhibits a high degree of genetic polymorphism that may affect its structure and stability, interfering with these cardioprotective actions.
Methodology:
Five ACE2-single nucleotide polymorphisms (SNP); rs4646188, rs2158083, rs233575, rs879922, and rs2074192, previously related with CV risk factors, were analyzed in a general population of adolescents and tested for potential associations with anthropometric and plasma parameters.
Results
Girls (n=461) exhibited lower rates of overweight and obesity, blood pressure, and glycemia than boys (n=412), though increased plasma lipids. The triglycerides (TG)/HDL-C ratio was, however, lower in females. Interestingly, only in girls, the occurrence of overweight/obesity was associated with the SNPs rs879922 [OR 1.67 (1.02-2.75)], rs233575 [OR 1.98 (1.21- 3.22)] and rs2158083 [OR 1.67 (1.04-2.68)]. Also, their highest levels of TG were linked to rs879922, rs233575, and rs2158083, and the highest TG/HDL-C ratio was assocated with rs879922 and rs233575. The upper levels of TC and LDL-C was associated with rs2074192 and rs2158083. Furthermore, the established cut-off level for TG ≥ 90 mg/dl was related with rs879922 [OR 1.78 (1.06-2.96)], rs2158083 [OR 1.75 (1.08-2.82)], and rs233575 [OR 1.62 (1.00 -2.61)]. The cut-off level for TC ≥ 170 mg/dl was associated with rs2074192 [OR 1.54 (1.04-2.28) and rs2158083 [OR 1.53 (1.04-2.25)]. In addition, the haplotype (C-G-C) derived from rs879922-rs2158083-rs233575 was related with higher prevalence of overweight/obesity and TG elevation.
Conclusion
The expression and activity of ACE2 may be essential for CV homeostasis. Interestingly, ACE2-SNPs rs879922, rs233575, rs2158083 and rs2074192, and haplotype (C-G-C) of the three former could induce vulnerability to obesity and hyperlipidemia in women. Thus, these SNPs might be used as predictive biomarkers for CV diseases and as molecular targets for CV therapy.
Conditional Knockout of PDK1 in Osteoclasts Suppressed Osteoclastogenesis and Ameliorated Prostate Cancer-Induced Osteolysis
Authors: Zhang Yanan , Nong Haibin , Bai Yiguang , Zhou Quan , Zhang Qiong , Liu Mingfu , Liu Pan , Zeng Gaofeng , Zong Shaohui
Published: December 2021

Background: The development and maintenance of normal bone tissue is supported by balanced communication between osteoblasts and osteoclasts. The invasion of cancer cells disrupts this balance, leading to osteolysis. As the only bone resorption cells in vivo, osteoclasts play important roles in cancer-induced osteolysis. However, the function of 3-phosphoinositide–dependent protein kinase-1 (PDK1) in osteoclast resorption remains unclear. Methods: In our study, we used a receptor activator of nuclear factor-kappa B (RANK) promoter‐driven Cre‐LoxP system to conditionally delete the PDK1 gene in osteoclasts in mice. We investigated the impact of Osteoclast‐specific knockout of PDK1 on prostate cancer-induced osteolysis. Bone marrow-derived macrophage cells (BMMs) were extracted and induced to differentiate osteoclasts in vitro to examine the function of PDK1 in osteoclasts.Results: In this study, we found that PDK1 conditional knockout (cKO) mice exhibited smaller body sizes when contrasted with the wild-type (WT) mice. Moreover, deletion of PDK1 in osteoclasts ameliorated osteolysis and reduced bone resorption markers in the murine model of prostate cancer-stimulated osteolysis. In vivo, we discovered that osteoclast‐specific knockout of PDK1 suppressed RANKL-stimulated bone resorption function, osteoclastogenesis, and osteoclast-specific gene expression (Ctsk, TRAP, MMP-9, NFATc1). Western blot analyses of RANKL-induced signaling pathways showed that conditional knockout of PDK1 in osteoclasts inhibited the early nuclear factor κB (NF-κB) activation, which consequently suppressed the downstream induction of NFATc1. Conclusion: These findings demonstrated that PDK1 performs an instrumental function in osteoclastogenesis and prostate cancer-induced osteolysis by modulating the PDK1/AKT/NF-κB signaling pathway.
A model proposal for estimating banks’ future value: Evidence from Turkey
Authors: Günay Burhan , Turan Kurtaran Ayten , Faedfar Sara
Published: December 2021

Investors make solid decisions when evaluating their investments based on positive indicators the firm may show in the future, rather than based on its past performance. Accordingly, this study aims to investigate the relationship between performance criteria and the most significant value-based criterion; Economic Value Added (EVA). Further, it evaluates the impact of future EVA values on the bank value. Panel Data Analysis and the OLS Regression model are used to estimate the regression equation. The analysis is performed using data of 10 banks on the BIST Banks Index over the period 2011 to 2020. Furthermore, the EVA criterion was converted into standardized EVA(SEVA) by dividing EVA by total assets. The OLS regression analysis results revealed that the model’s explanatory power for the SEVA variable is 71.92%. The three variables that have positive correlation with SEVA are earnings per share (EPS) and TOBINQ rates at the 1% significance level and the price to sales growth rate with a degree of significance at 10%. Regarding the Panel Data Analysis results, while the explanatory power of the SEVA variable is 72.14%, its association with the EPS and TOBINQ criteria was found to be significant at the 1% significance level. The empirical investigations reveal that the model developed using the future SEVA as a proxy for bank value is found to be promising, and it is accepted that the SEVA variable can be used instead of the bank value.
How to build trust: Evidence from Thai customers in the latex glove industry
Authors: Kim Long , Maijan Pattarawadee , Jindabot Teerasak , Bostan Ali Wanamina
Published: December 2021

This paper examined the impact of product quality, perceived risk, and perceived value on customer trust in the latex glove industry of Thailand. It used a structural equation model (SEM) to analyze the association between two or more variables. Data collection was conducted in Thailand during the pandemic of COVID-19. Five hundred people looking for glove protection were invited to join the survey; however, only 384 provided responses were valid enough for the data analysis. According to the empirical results of this study, product quality demonstrated significant and positive impacts on perceived value and trust. In addition, perceived value acted not only as a significant and positive predictor of customer trust but also as a partial mediator between product quality and customer trust. On the other hand, the current results demonstrated that perceived risk had little impact on perceived value and trust, while product quality was the primary benefit for increasing perceived value and trust among customers. Thus, ambiguity among customers was unlikely to demonstrate any serious concern for customer value and trust. Overall, customer trust relied significantly on perceived value through increased product quality.
AcknowledgmentThis study was supported by Internal Research Grant Funding of Academic year 2021, Hatyai University and Postdoctoral Fellowship, Prince of Songkla University.
FORMATION OF SOCIAL COMPETENCE OF TEACHING STAFF IN THE MODERN EDUCATIONAL SPACE
Authors: Finin Heorgii
Published: December 2021

The article substantiates the importance of forming the social competence of teachers. It was found that modern society needs specialists who know how to socialize in a fleeting society, people who are creative, active, competitive, competent, capable of change, with flexible critical thinking, to provide socio-pedagogical support of socialization, to form key and subject competencies of general secondary and higher education students.
US EDUCATIONAL FOREIGN POLICY AS A “SOFT POWER” FACTOR: RETROSPECTIVE ASPECT
Authors: Panfilov Oleksandr , Savchenko Olga
Published: December 2021

The subject of the article is education as a component of US foreign policy that was used and still is as an efficient and influential factor in the development of society oriented to American values, viewpoints, and way of life. The goal of the article is to analyse the place and role of education in the US foreign policy strategy in the modern era, while the main objectives are to specify the strategic directions of using education as a “soft power” by the United States as well as identify specific mechanisms that enable achieving the most effective results in this direction. Within the study, all the above objectives are solved. In particular, the main results obtained include the following: the historical context of the US use of education as a “soft power” tool is studied, the strategic directions of using educational potential as a “soft power” are analysed, the areas where educational efforts of the United States have always been concentrated are singled out. The US experience in the sphere of educational services export can be used to specify and theoretically substantiate the capabilities of Ukraine to advance its interests in the international arena using the educational opportunities our country can suggest to the world.
CRITICAL REVIEW OF J. CHAN'S MODEL OF SOCIAL COHESION MEASUREMENT: PERSPECTIVES OF ADAPTATION TO THE UKRAINIAN CONTEXT
Authors: Deineko Oleksandra
Published: December 2021

The article is devoted to identifying the "weaknesses" of J. Chan's model of social cohesion theoretical conceptualization and empirical measurement and outlining promising areas for its adaptation to the Ukrainian context. It's summarized the necessity of refining the definition of social cohesion from the standpoint of social dynamics, supplementing the subjective component of the model with "value" indicators, diversification with projective issues in order to avoid the "spiral of silence" and Lapierre's paradox.
Embroidery and Textiles: A Novel Perspective on Women Artists’ Art Practice
Authors:   PhD Scholar, School of Art & Design, Wuhan University of Technology, Wuhan, China, Rani Sunanda , Jining Dong ,   Professor, School of Art & Design, Wuhan University of Technology, Wuhan, China, Shah Dhaneshwar ,   PhD Scholar, School of Art & Design, Wuhan University of Technology, Wuhan, China
Published: December 2021

The manuscript focuses on the autobiographical artistic practice of women artists and feminist expression in visual art, particularly those women artists who use embroidery and textiles as mediums, techniques, processes, styles, subjects, and themes. Women artists often use a variety of unique materials and techniques to create artwork which are primarily related to them and show a feminist identity. The research explores the mediums, tools and techniques applied by women artists in their artworks and the reasons behind choosing that particular medium and methods. In addition, women artists when, where, and how these diverse creation strategies have been adopted and developed over time are examined and analysed with the help of earlier literature, articles, research papers, art exhibitions, and artworks created by women artists. This manuscript discusses the chronological development of embroidery and textiles in the context of women’s art practice, the efforts and achievements of the “Feminist Art Movement” and the cause and concept of “Entangled: Threads & Making”, a contemporary woman artist art exhibition at Turner. Embroidery and textiles are associated with women’s art practice; women artists used embroidery, needlework, and textiles as a powerful symbolic medium of expression and resistance against the male-dominated art society. They began to use feminist expressions, forms, and materials to present their new characteristics. Women artists use embroidery, textiles and needlework as feminist traditional materials and techniques, and continue to struggle to blend them with other new contemporary mediums.
Ideological Reconfigurations: Privacy, Voyeurism and Form in Recent Malayalam Cinema
Authors:   Research Scholar, Department of Cultural Studies, The English and Foreign Languages University, Hyderabad, Abhijith B.
Published: December 2021

This paper traces a particular moment in the recent history of Malayalam Cinema when a shift in the representation of the private sphere was attempted. In the period after 2010, a set of new Malayalam films carried a shift in terms of aesthetics and narrative techniques and went on to unfold in a full-fledged manner by the end of the decade. The paper would look at Chappa Kurishu (Head or Tails, 2011), one of the early movies of this tide to shed light on the remarkable shift it achieves in representing the scenes of romantic and erotic intimacy on screen. As the narrative of the movie centers around the fight over a smart phone that ensues between two strangers in the city of Kochi, it gets entangled with questions of privacy, class and contest over the urban spaces. Bringing to the discussion contestations over the meanings of public and private manifested in certain urban-based movements in recent times like ‘Kiss of Love’ protests, it is argued that Chappa Kurishu can be read as a response to the contradictions arising out of the emergence of new subjects in the wake of urban transformations and the conflicting cinematic publics of multiplex and single hall theatre. The formal transactions between cinematic form and video form, the paper suggests, is one of the ways in which Chappa Kurishu attempts to respond to this situation in a way that signals the transitional position of the spectator subject.
Tyrannous Minds and Tamed Bodies: The Curious Case of Irene Adler from Canon to Screen
Authors:   Assistant Professor, School of Languages, KIIT Deemed to be University, Roy Debanjali , Putatunda Tanmoy ,   Assistant Professor, School of Languages, KIIT Deemed to be University
Published: December 2021

Appearing in the singular short story “A Scandal in Bohemia” in Sir Arthur Conan Doyle’s Sherlock Holmes series, the character of Irene Adler has been adapted and reconstructed in subsequent literary and visual media. Twenty-first century screen adaptations have swivelled upon postfeminist re-appropriations of the character and overt sexualisation of the ‘body’, thereby engaging in reassessment of the Irene-Sherlock relationship and problematizing gendered presentations of the character. Locating Irene in a heteronormative space, such narratives have attempted to revise the image of the cross-dressing ‘adventuress’ through varied portrayals which seemingly broaden her scope by means of her deliberate transgressions of fixed gender tropes. This article, by taking into account the gendered power-play embedded in three popular twenty first century screen adaptations of the text, namely, the films Sherlock Holmes (2009) and Sherlock Holmes: A Game of Shadows (2011), CBS’s Elementary (2012-2019) and BBC’s Sherlock (2010-2017), scrutinizes the dilemma of presentation of Irene Adler through the lenses of sexual dynamics and gendered performances.
Simulation-optimization framework in urban flood management for historic and climate change scenarios
Authors: Madhuri R. , Sarath Raja Y. S. L. , Srinivasa Raju K.
Published: December 2021

A simulation-optimization framework is established by integrating Hydrologic Engineering Center Hydraulic Modeling System (HEC-HMS) for computation of runoff, siting tool EPA System for Urban Storm-water Treatment and Analysis INtegration (EPA-SUSTAIN) for placement of Best Management Practices (BMPs), and Binary Linear Integer Programming (BLIP) for runoff reduction. The framework is applied to an urban catchment, namely Greater Hyderabad Municipal Corporation (GHMC). The rainfall-runoff analysis was conducted for extreme rainfalls for historic (2016) and future events in 2050 and 2064 under Representative Concentration Pathways (RCPs) 6.0 and 8.5. The simulation-optimization approach in the historic scenario yielded 495,607 BMPs occupying 76.99 km2 resulting in runoff reduction of 21.54 mm (198.76–177.22 mm). Achieved runoff reduction is 38.72 (428.35–389.63 mm) and 55.03 (602.65–547.62 mm), respectively, for RCPs 6.0 and 8.5, which could meet the water demands of GHMC for 10.33 and 11.53 days. Impacts of 10 different BMP configurations of varying costs (10–70%) and pollutant load reductions (0–3%) on runoff reduction are accomplished as part of sensitivity analysis.
Huaranhuay
Authors: Quispe Farias Valeria
Published: December 2021

Árbol de 32 cm de circunferencia y 5 m de altura total con fuste cilíndrico a irregular, ramificación simpodial desde el primer tercio de altura, base del fuste sin modificaciones.
Zorro andino
Authors: Vilca-Portillo Jenny , Monteverde-Calderón Enrique  Gianlucca
Published: December 2021

El zorro andino es considerada la especie de cánido más grande entre todos los zorros sudamericanos, puede llegar a medir hasta 1,7 m incluido la cola (Mendoza, 2019) y pesa entre 4 a 13,8 kg (Guntiñas-Rosado, 2018). Físicamente su cabeza y hocico son anchos y bien pronunciados, de apariencia triangular, orejas muy evidentes rectas y triangulares. Su pelaje es largo y tupido, el dorso incluyendo la cabeza, las orejas y el cuello, así como las piernas y los flancos presentan un color rojizo con apariencia leonada. En la barbilla y en las partes inferiores del cuerpo se observan zonas de color blanquecino, la cola es corta, larga, peluda y de color grisáceo con la punta de color negro y una mancha oscura dorsal cerca de su base; esta puede alcanzar el 50% de la longitud de la cabeza y cuerpo junto. Los machos son más grandes que las hembras (Lema, 2018).
Synthesized NaA Nanozeolite as a Catalyst for the Preparation of 3-amino imidazo[1,2-a]pyridines under Solvent-Free Conditions
Authors: Azargashb Sara , Sarvary Afshin , Hassaninejad-Darzi Seyed Karim
Published: December 2021

The present study explores a new method for the fabrication of NaA nanozeolite as a simple and efficient catalyst for producing 3-aminoimidazo [1,2-a] pyridines via the 3-component reaction of aldehydes, 2-aminoperidines and isocyanides under solvent-free conditions. The production of the organic template-free (OTF) NaA nanozeolite was performed at room temperature. The prepared nanozeolite was identified by X-ray diffraction (XRD), Fourier Transform infrared spectroscopy (FT-IR), Field Emission Scanning Electronic Microscopy (FESEM), N2 sorption isotherm and Particle Size Analysis (PSA). The particle sizes of synthesized spherical NaA nanozeolite were under 100 nm via the FESEM method. BET surface area, total pore volume, and mean pore diameter of the created sample were attained to be 362 m2g-1, 0.44 cm3 g-1 and 5.9 nm, respectively. The developed method has some advantages, such as OTF production of NaA nanozeolite, a simple synthesis method with short reaction time and easy separation using filtration, and the ability to recycle and reuse the catalyst several times without reducing its efficiency.
COVID-19 Vaccination in Children: An Open Question
Authors: Bardanzellu Flaminia , Campagnani Giuseppe , Pintus Maria Cristina , Fanos Vassilios , Marcialis Maria Antonietta
Published: December 2021

Background:

A safe and effective vaccine represents the best way to control the
COVID-19 pandemic, which has caused more than 4 million deaths to date. Several vaccines have
now been approved worldwide, depending on the country. Being administered to healthy people,
anti-SARS-CoV-2 vaccines must meet high safety standards, and this is even more important
among the pediatric population in which the risk of developing severe disease is significantly lower
than adults. However, vaccination of the pediatric population could help in reducing viral spread in
the whole population.

Objective:

Our narrative review analyzes and discusses the currently available literature on the advantages
and disadvantages of COVID-19 vaccination in the pediatric population.

Methods:

A bibliographic research was conducted through Pubmed, Read, and Scopus using
COVID-19, SARS-CoV-2, immunization, antibody, COVID-19 vaccine efficacy, COVID-19
vaccine safety, children, adolescents, MIS-C, adverse effects as keywords.

Results:

Although children are less susceptible to COVID-19 infection, they can develop serious
consequences, including multi-inflammatory syndrome. However, any vaccine-related side effects
should be evaluated before administering vaccination to children while ensuring complete safety.
To date, adverse effects are reported in adolescents and young adults following vaccination; however,
these are mostly isolated reports.

Conclusions:

Further investigation is needed to establish whether there is indeed a cause-and-effect
relationship in the development of vaccine-related adverse effects. However, to date, COVID-19
vaccination is recommended for children and adolescents older than 12 years of age. However, this
question is still under debate and involves ethical, political, and social issues.
Hepatic Lipid Metabolism Disorder and Atherosclerosis
Authors: Zhang Sen , Hong Fenfang , Ma Chen , Yang Shulong
Published: December 2021

:

Lipid metabolism disorder plays a fundamental role in the pathogenesis of atherosclerosis. As the largest metabolic organ of the human body, liver has a key role in lipid metabolism by influencing fat production, fat decomposition, and the intake and secretion of serum lipoproteins. Numerous clinical and experimental studies have indicated that the dysfunction of hepatic lipid metabolism is closely tied to the onset of atherosclerosis. However, the identity and functional role of hepatic lipid metabolism responsible for these associations remain unknown. This review presented that cholesterol synthesis, cholesterol transport, and the metabolism of triglyceride, lipoproteins, and fatty acids are all associated with hepatic lipid metabolism and atherosclerosis. Moreover, we also discussed the roles of gut microbiota, inflammatory response, and oxidative stress in the pathological association between hepatic lipid metabolism and atherosclerosis. These significant evidences support strongly that hepatic lipid metabolism disorders may increase the risk of atherosclerosis.
Fabrication of Cefixime Nanoparticles Loaded Films and their Ex Vivo Antimicrobial
Effect on Periodontitis Patient’s Saliva
Authors: Parmar Rakeshkumar , Salman M Mohammad , Chauhan Payal
Published: December 2021

Aim:

This study was designed to prepare and evaluate cefixime-loaded nanoparticles
containing low molecular weight chitosan films for the enhanced topical treatment of periodontitis.

Methods:

To fabricate the enhanced antimicrobial films, a nanoprecipitation method for cefixime
nanoparticles followed by a solvent evaporation method for these nanoparticles loaded films were
adopted in this study. Nine batches of nanoparticles (NPs) with different concentrations of ethyl cellulose and polyvinyl alcohol were prepared and evaluated. Furthermore, nine batches of optimized
NPs loaded films with different concentrations of low molecular weight chitosan and glycerol were
fabricated and evaluated. Optimized NPs loaded films were assessed for their antimicrobial activity
against the periodontitis patient’s saliva samples.

Results:

The FT-IR spectroscopy and XRD study revealed that there was no interaction between
the drug and all other excipients and the drug remained amorphous form in chitosan film. The
SEM study revealed that the prepared NPs were spherical in shape and uniformly distributed in chitosan film. In vitro drug release study revealed the NPs have a sustained release profile up to 8
days and NPs loaded films have up to 11 days. The conventional marketed mouth wash shows a
low inhibition zone of 5.70 ± 0.043 mm, whereas NPs loaded film shows a higher inhibition zone
of 6.72 ± 0.063 mm against periodontal microorganisms present in the patient’s saliva. The stability study revealed that the optimized NPs loaded film shows no dramatic change in drug release profile and folding endurance after six months.

Conclusion:

This present study highlights the possible usage of cefixime NPs loaded films in enhanced periodontal treatment.
A Review Article on the Therapeutic Potential of Medicinal Plants for Prevention and Treatment of Secondary Infection in Patients with COVID-19
Authors: Patil Asmita Gajbhiye , Rathore Swati , Tiwari Richa Tripathy , Rai Neha , Mahapatra Debarshi Kar , Patil Shailendra
Published: December 2021

:

COVID-19 is an infectious disease, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) that is rapidly spreading all over the world and responsible for the international health crisis. In an earlier period, various synthetic antiviral drugs and clinical therapies have been used to control the viral infection but at present, there is no specific treatment available for COVID-19 infection. Several approaches like ritonavir, lopinavir, hydroxychloroquine, and chloroquine have been proposed. India is a hub of medicinal plants, so there is a chance to find out the way to combat the COVID-19 pandemic. The medicinal herbal formulations may enhance the immunity and come up with a powerful antiviral drug, which is an urgent need to control the outbreak of coronavirus. In this review article, we have discussed epidemiology, clinical outcomes, treatment, and prevention of this novel epidemic coronavirus from medicinal herbal formulations perspective. We have also emphasized the reported antiviral activity and immunity-boosting property of the Indian medicinal plants. This article also suggests that the drug or formulation obtained from medicinal plant sources may have low fatal outcomes, quick response, and safe in the management and prevention of this pandemic outbreak.