bluuebunny/crossref_metadata_2025 huggingface dataset:
Issues of Declining Livestock Breeds: Revisiting Domestic Animal Diversity in Pastoral Systems
Authors:   Independent Researcher & Consultant, Editor of Nomadic Peoples, Associate Research Fellow at the German Institute for Tropical and Subtropical Agriculture, and Transdisciplinary and Social-ecological Landuse Research (DITSL), Germany.  Email: saverio.kratli@gmail.com, Krätli Saverio
Published: April 2023

Concerns for the disappearance of local breeds go back to the beginning of scientific breeding and the early national policies of agriculture intensification in Europe at the time of the industrial revolution. That initial Eurocentric framing of domestic animal diversity as ‘local’ breeds, largely the result of natural selection and potentially a useful source of ‘raw’ genetic material, remains dominant. Today, however, the debate around domestic animal diversity has been globalized, and so includes livestock breeding populations and livestock systems that developed outside the European experience. This paper looks at domestic animal diversity from the vantage point of one of such cases: cattle breeding among the Wodaabe pastoralists in Niger. The research is based on a combination of qualitative methodologies standard in social anthropology and quantitative analysis of memorized herd genealogies over a 20-year period. Results show that a competent herder can control cattle mating in over 90 percent of cases. Complex learned behaviour in cattle, particularly related to feeding competence, is a major selection criterion. The Wodaabe specialize in using the short-lived and unpredictable grazing opportunities, which is characteristic of Sahelian rangelands. To successfully interface the unpredictable variability in potential inputs, they breed herds with exceptional levels of within-breed diversity, crucially including epigenetic traits. The common practice of conflating Domestic Animal Diversity (DAD) with Animal Genetic Resources (AnGR), therefore, falls short of adequately representing the relationship between ‘local breeds’ and livelihood in pastoral systems.
Livelihood Transformation among the Borana Pastoralists of Dhas District, Southern Ethiopia
Authors:   Institute of Indigenous Studies, Dilla University, Dilla, Ethiopia.  Email: dejenea987@gmail.com, Alemayehu Dejene , Hizekeal Yetebarek ,   Institute of Indigenous Studies, Dilla University, Dilla, Ethiopia.  Email: yetebarek-h.zekareas@connect.polyu.hk, Petros Tesfatsion ,   Institute of Indigenous Studies, Dilla University, Dilla, Ethiopia.  Email: petrostesfatsion@gmail.com, Arjjumend Hasrat ,   The Grassroots Institute, 548 Jean Talon Ouest, Montreal, QC, Canada.  Email: ceo@grassrootsinstitute.ca
Published: April 2023

This study intends to examine the triggers of livelihoods transformation among the Borana pastoralists of Dhas district in Borana zone, southern Ethiopia. The Participatory Rural Appraisal (PRA) tools, such as key informant interviews and focused group discussions, were used to explore the perceptions of local communities on the causes of livelihood transformation and its impact on the well-being of pastoralists and their overall survival. Purposive sampling was used to administer key informant interviews and FGDs. The findings of this study indicate that the foremost causes of livelihoods transformation in Dhas district include frequent drought and environmental degradation, pastoralists’ sedentarisation policies and conflict over boundary and grazing lands. Previously, pastoralism livelihood system was the most viable strategy in the study area providing sustainable livestock products, while, at the same time, protecting water and rangeland resources and safeguarding environment warrant the Borana pastoralist’s well-being. However, with the changing livelihood dynamics, the Borana’s pastoral system underwent major upheavals, enfeebling the pragmatism of these practices. Therefore, this study concludes that a comprehensive development strategy for supporting pastoral livelihood becomes the need of the hour to guide the efforts of all relevant stakeholders operating in pastoral areas.
Technological Strategies Implemented by Livestock Farmers Specialized in Goat Breeding in the Mountain Region of San Juan, Mendoza and La Rioja Provinces in Argentina
Authors:   Area of Research and Technological Development for Family Farming, CR Mendoza – San Juan, National Institute of Agricultural Technology of Argentina, Argentina.  Email: guzman.fernando@inta.gob.ar, Guzmán Fernando Diego , Alberghini Juan Pablo ,   Area of Research and Technological Development for Family Farming, CR Mendoza – San Juan, National Institute of Agricultural Technology of Argentina, Argentina.  Email: alberghini.juan@inta.gob.ar
Published: April 2023

The goat farming is of great relevance in the mountain ranges of San Juan, La Rioja and Mendoza Provinces in Argentina. Out of the three, Mendoza province has the highest number of goats in the country. This system of production is majorly managed by the family members making it an integral part of the Family Farming sector.. This type of production generates work in a pauperized sector and at such places that are distant from the urban centres where possibility of alternative occupations is scare or almost nil. The animal rearing activity focuses on primary production with little value addition, high seasonality, and informal and rudimentary marketing strategies. These activities primarily employ tacit knowledge acquired over the years by trial-and-error method. Transhumance, as a strategy for the use of the natural environment, reveals the existence of a thorough knowledge of the seasonal productivity of the grasslands of the mountain valleys. Research and extension organizations develop projects aimed at improving these production systems through the implementation of contemporary technologies. The objective of this paper is to identify the technological strategies implemented by the Family Farming sector specialized in goat breeding in the mountain region of the provinces of Mendoza, San Juan and La Rioja, with specific focus on their origin, specific problems they face, and strategic similarities and differences to propose recommendations for the research and extension organizations.
Camel Systems and Pastoralists’ Lifestyle in Semi-Deserts and Mountains: Constraints and Challenges
Authors:   Therapeutic Nutrition Department, Faculty of Health Sciences, Misurata University, P.O. Box 2478, Misurata, Libya.  Email: a.yassien@nurs.misurata.edu.ly, Mustafa Ayman Balla , Faraz Asim ,   Department of Livestock and Poultry Production, Bahauddin Zakariya University, Multan, Pakistan.  Email: drasimfaraz@bzu.edu.pk
Published: April 2023

Camels are vital to the daily life of all desert dwellers, especially Bedouins, for whom they form a source of food, a means of transportation and recreation. To appreciate the unique contribution that Arabian camels make towards the community life and the history of the desert lands, in this paper, the pastoral production systems observed across three major regions - Butana, Kordofan and Darfur - are discussed. The field survey based study was conducted from August 2011 to May 2014 using structured interview method to determine the limitations and challenges faced by camel pastoral community in main camel production regions of Sudan. The results revealed that the average of calving interval was 30 months; male camel is rutting for 3 months during rainy season. She-camel gives birth to 6-8 calves throughout the life. The average milk yield was 3 liters per day with the lactation period extended to more than 10 months. The calf is weaned for 10 months or more. Social prestige and continuity of traditional heritage are the major reasons for keeping animals rather than economic revenue. However, it was found that the security issues are limiting camel breeding practices and pastoralists’ movement in the semi-desert and mountain regions. Internal conflicts between farmers and pastoralists that often develop into tribal wars also affected pastoral production systems. Such constraints in addition to the lack of government support and favorable policies present major challenges to camel pastoral system in the region.
Editorial: Retrospective, Challenges, and Persistence
Authors: Bowman Sarah Lynne , Torner Evan , White William J.
Published: April 2023

Editorial: Retrospective, Challenges, and Persistence
Not Only Play: Experiences of Playing a Professor Character at College of Wizardry with a Professional Background in Teaching
Authors: Homann Juliane
Published: April 2023

This article investigates how participants that have played professor characters in the sandbox-style Nordic Larp College of Wizardry reflected on planning and conducting play-pretend lessons compared to their experiences of teaching in professional environments. Using the concepts of spillover, bleed, compensation, role conflict, and contrast, this article focuses on how such experiences can contain reversals of playful and serious motivational states. Data was obtained by interviewing nine participants from various countries: areas of subject expertise; amounts of teaching and larping experience; and levels of education (primary, secondary, tertiary, and vocational). Qualitative content analysis (Mayring 2002) was used to evaluate the guideline-structured interviews via a category system developed from a theoretical framework, combining the research findings of Fenstermacher et al. (2009), Apter (2008), Banner (1985), Biddle (1983 and 1979), Staines (1980) and Kando and Summers (1971). The results of this investigation show that all interviewees drew on their professional teaching experiences for planning and conducting play-pretend lessons at College of Wizardry. Despite the fictionality of the setting, interviewees identified several parallels, such as approaches to teaching and an awareness for student/player needs. Playing a professor at College of Wizardry with a professional background in teaching provided an opportunity to explore and experiment, due to the absence of expectations present in professional settings. Educators larping their role enjoyed more liberty, yet also encountered familiar real-world stress factors.
International Journal of Role-playing 11 -- Full Issue -- IJRP
Authors: Torner Evan , Bowman Sarah Lynne , White William J. , Albom Sarah , Leonard Diana J. , Janjetovic Jovo , Usman Maximilian , Lasley Joe , Lehto Kerttu , Baird Josephine , Geneuss Katrin
Published: April 2023

IJRP 11: Full Issue

Table of Contents

Evan Torner, Sarah Lynne Bowman, and William J. White, “Editorial Introduction to Issue 11”

Some context for the current issue, especially with regard to current critiques of themes of violence and oppression in games, as well as this year’s Call for Papers on Applied Role-playing Games and the excellent articles submitted in response.

Sarah Albom, “The Killing Roll: The Prevalence of Violence in Dungeons & Dragons”

A textual analysis evaluating the language used in the Dungeons & Dragons 5th Edition Player’s Handbook. This article discusses the ways that the text incentivizes characters to take violent actions more often than offering peaceful solutions.

Diana J. Leonard, Jovo Janjetovic, Maximilian Usman, “Playing to Experience Marginalization: Benefits and Drawbacks of ‘Dark Tourism’ in Larp”

An examination of how playing characters with marginalizations the player does not share can lead to perspective taking and empathy, but can also cause harm if not done with care.

Joe Lasley, “Fantasy In Real Life: Making Meaning from Vicarious Experiences with a Tabletop RPG Internet Stream”

A qualitative study examining seven fans of the livestream show Critical Role, in which actors play Dungeons & Dragons. The fans described an increase in their well-being due to parasocial relationships with the fiction and players in the show.

Kerttu Lehto, “Role-Playing Games and Well-Being”

A secondary literature review discussing the main themes in role-playing game studies, as well as arts and well-being as fields of study. This author advocates for more dialogue between these fields as a fruitful line of inquiry, especially with regard to the design of games for personal development and well-being.

Josephine Baird, “Role-playing the Self – Trans Self-Expression, Exploration, and Embodiment in Live Action Role-Playing Games”

An autoethnography blending gender theory with personal experience exploring gender in role-playing games and other performance spaces. The author considers how best to design larps explicitly to help trans people embody their identities.

Katrin Geneuss, “The Use of the Role-playing Technique STARS in Formal Didactic Contexts”

A summary of Design-based Research on 16 educational live action role-playing games (edu-larps) created for German schools. This article offers several best practices for educators who seek to implement edu-larp in the classroom.
International Journal of Role-playing 8 -- Full Issue -- IJRP
Authors: Bowman Sarah Lynne , Koziej Ken , Hellström Mikael , Loh Magdalene , Rezende Rian , Araujo Sabrina , Portinari Denise , Weiner Susan
Published: April 2023

International Journal of Role-playing 8 -- Full Issue -- IJRP
Case Studies as Tabletop RPGs
Authors: Weiner Susan
Published: April 2023

For many college educators, case studies provide a relatively easy form of active learning to implement. Students connect with them and can see the application and value. There are resources for published case studies available for free online and they can be applicable to almost any topic. However, frequently, case studies mostly involve research that can be divided up among group members with perhaps a few thinking and discussing questions at the end. In this article, I introduce a method of implementing case studies using a tabletop framework, allowing students the agency to make decisions that have impact within the world of the case study. Approaching the case study like a tabletop role-playing game (RPG) provides a more interactive and realistic feeling format. In a tabletop RPG, generally the players specialize. They have roles that only they can provide. Similarly, students can become “specialists” on their part of the case study and bring that expertise back. They may take on the role of particular stakeholders within the issue they are addressing. This structure allows students to teach each other and also discourages “slacking” in which a few people do all the work for the group. This method can also allow for a “role-playing” aspect, in which a student is considering the decisions that are relevant to their specialty from the specialist’s perspective. Also, in a tabletop RPG, there are many points at which the players need to make decisions that affect what happens to their characters in the follow-up. While there are many divided case studies, most of them do not change based on decisions made in prior parts. Due to the interactive nature and direct responses to student decisions, students can feel like their answers matter and get feedback about their choices. Depending on class size, length, and preparation, the results may come within a class session or between class sessions. Either way, their actions matter. These pieces together can give students a sense of ownership and agency over their work and improve understanding of complicated topics.
Legal Liability in Live Action Role-Playing: The Law is Dark and Full of Terrors
Authors: Murdock Russell
Published: April 2023

This paper explores the legal liabilities and risks associated with running a live-action role-playing game (larp). Because few cases directly involving the larp community have been litigated, this paper searches for corollaries from other types of events run mainly in the United States that may prove enlightening for larp organizers. While the legal concerns faced by larp organizers may seem novel to them, many similar issues of legal liability have been litigated in courts for more than a century. The legal principles of social host liability vs. commercial host liability will be analyzed in the context of larps, demonstrating some of the likely disparate treatment for-profit larp organizers will experience versus their non-commercial counterparts. These principles will provide the foundation to analyze liability regarding the furnishing of alcohol in contexts when alcohol is being sold by the larp’s organizers, when it is given away by organizers, and when organizers provide alcohol to an underage minor. This paper also explores other liability concerns for larp organizers, including their responsibility resulting from criminal actions by participants; criminal or negligent acts by their employees and volunteers; and personal injury of a participant at a larp event. Finally, the paper will briefly explore the liability of the landowner of sites where larps take place. Where clear bright-line answers to legal questions prove impossible—as they all too often do—this paper seeks to provide a general foundation of knowledge from which larp organizers can begin to analyze their legal liabilities. This article is intended for informational purposes only and not for the purpose of providing legal advice.
INDIVIDUAL METHODS OF HEALTH EDUCATION IMPROVING KNOWLEDGE AND ATTITUDES OF PREGNANT WOMEN ABOUT HEPATITIS B
Authors: Yanniarti Sri , Revika Nova , Widiyanti Desi , Savitri Wewet , Rahayu Else Sri
Published: April 2023

Hepatitis B in pregnant women causes coagulation effects, organ failure, and increased maternal mortality, while in newborns, it causes asphyxia and low birth weight. Pregnant women need to know about Hepatitis B and have a positive attitude to prevent transmission to pregnant women. It can be improved through health education. This study aims to determine the effect of individual method health education with leaflet media on increasing knowledge and attitudes of pregnant women about Hepatitis B at the Sidodadi Health Center Bengkulu Tengah in 2022. The research design was quasi-experimental with a non-equivalent control group design, with a pre-test post-test control group approach. The population is all pregnant women in the area of the Sidodadi Health Center in 2022, amounting to 37 people, using the Lemeshow formula, a sample of 34 respondents (17 in intervention groups and 17 in comparison). Data were analyzed using the dependent T-test, and Wilcoxon signed rank test. There is a difference in the average knowledge score and attitudes before and after being given individual method health education with leaflet media. There is a significant difference between the two groups with ?= 0.000. It means that there is a significant effect on individual method health education with leaflet media on knowledge and attitudes of pregnant women about Hepatitis B at the Sidodadi Health Center in 2022, with a mean difference of 3.47 on the knowledge variable and 5.65 on the attitude variable. A diversity of counseling methods is needed to increase the knowledge and attitudes of pregnant women about Hepatitis B. Health workers must increase their role in improving methods and media in providing counseling to pregnant women to prevent transmission of Hepatitis B.
PROGRAMAS DE PREPARACIÓN DE SALIDA PARA POTENCIALES JUBILADOS, COMO RESPUESTA A LA RESPONSABILIDAD SOCIAL EMPRESARIAL (RSE)
Authors: González Guajardo Jesús Emilio , Zúñiga Cortez Juan Hermilo , Gutiérrez González Leonor , Ballesteros Martínez Marla María Elena
Published: April 2023

El trabajo considera los impactos negativos en jubilados y potenciales jubilados de empresas del centro de Coahuila y su objetivo general es el de proponer ayuda previa como responsabilidad empresarial. Se identi­fican tres figuras: empresa, potenciales jubilados y jubilados con mues­tras representativas de 284, 211 y 117 respectivamente; hallazgos: 283 de 284 empresas desconocen los programas de salida (PSPJ). 117 jubilados, 68(59%) son anticipados, 49(41%) con más de 65 años. Existe relación entre la problemática interna y externa en los trabajadores antes y después de jubilarse por la falta PSPJ. Conocer su próxima salida, 162(77%) de 211 casos se ven emocionalmente afectados; 197 de 211 requieren orienta­ción; indicadores de apoyo: 113(96.6%) Salud física; 107(91.45%) Salud mental; Nuevo Presupuesto Económico, 98 (83.8%), Relaciones Familia­res, 89 (76.06%), Relaciones Sociales, 86 (73.50%), Derechos y Obliga­ciones, 45(38.46%). Como RSE, se propone incluir PSPJ en los modelos de GRH y su mecánica operacional.
LAS TIC Y SU IMPACTO EN EL DESEMPEÑO ACADÉMICO DE LOS ESTUDIANTES UNIVERSITARIOS
Authors: Hernández Barrera Mónica , Guerrero Dávalos Cuauhtémoc
Published: April 2023

En este artículo se revisan varias publicaciones referentes al impacto que tienen las Tecnologías de la Información y Comunicación (TIC) en el ámbito educativo, en especial en la educación superior. Se identifican los principales indicadores que se han usado para medir el impacto que es­tas tecnologías tienen sobre el rendimiento académico de los estudiantes universitarios. Se concluye que a nivel internacional existe una variedad de indicadores que aún no se han estandarizado, debido a la gran diversidad de condiciones económicas, sociales y culturales tanto de universidades como de profesores y estudiantes en diferentes lugares del mundo, que hacen que los estudios actuales referentes al impacto que tienen las TIC sobre el rendimiento académico de los estudiantes sean casos particulares.
EL NIVEL ACADÉMICO DE LOS ADMINISTRADORES Y SU INFLUENCIA EN PROPICIAR LA INFORMACIÓN EN PYMES CENTRO ESTADO DE COAHUILA
Authors: Zúñiga Cortez Juan Hermilo
Published: April 2023

El objetivo es demostrar que el nivel académico de los administradores es insuficiente en relación con la importancia determinante que tiene la información que requieren generar las PYMES. El instrumento se valida mediante consulta a expertos académicos y administradores de empresa, la confiabilidad coeficiente α (alfa) de Cronbach (0.805), la muestra de 157 casos; el nivel de confianza 95%, la información se registra en SPSS 21.0 y Excel: las empresas logran mantener su operación y su planta laboral. Sin embargo, el nivel académico de los administradores y la información son aspectos importantes relacionados con el problema de la investiga­ción; las tres cuartas partes de los administradores tienen nivel licenciatura, (46,2%) no cuenta con información financiera, no se elabora en tiem­po los reportes que resultan de su operación, además carecen de sistemas integrales contables-administrativos. No se rechaza la hipótesis mediante chi-cuadrada, las PYMES deben gestionar más la información; las conclu­siones de este trabajo son coherentes con las opiniones vertidas por otros autores y los empresarios deben considerar contar con personal con nivel posgrado en sus áreas directivas.
FACTORES DE INFLUENCIA EN LA TRAYECTORIA ESTUDIANTIL DE LA FACULTAD DE ECONOMÍA DE LA UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO: UN ANÁLISIS CON MODELOS ECONOMÉTRICOS CUALITATIVOS, 2013-2014
Authors: Gómez Monge Rodrigo , González Pérez José Manuel
Published: April 2023

En la presente investigación se estudian los aportes teóricos y metodo-lógicos del análisis cualitativo realizado con modelos econométricos, así mismo se genera una revisión de diversos estudios que han buscado iden­tificar las principales características que inciden en el aprovechamiento de los estudiantes del nivel superior. En un segundo apartado se realiza una contextualización de la Facultad de Economía “Vasco de Quiroga”, de­pendiente de la Universidad Michoacana de San Nicolás de Hidalgo, así como de las licenciaturas en comercio exterior y economía que oferta. En la tercera parte se presenta la aplicación de la metodología econométrica para identificar algunas variables claves que impactan en el desempeño aca­démico de las dos licenciaturas. Finalmente se muestran las conclusiones a que se llegan en el estudio.
TEORÍA DE LOS EFECTOS OLVIDADOS EN LA INCIDENCIA DE LA ACTIVIDAD ECONÓMICA EN LA CALIDAD DE VIDA DE LOS HABITANTES Y CUANTIFICACIÓN DE LOS EFECTOS PARA UN REEQUILIBRIO TERRITORIAL
Authors: Gil Lafuente Anna María , González Santoyo Federico , Flores Romero Beatriz
Published: April 2023

Los gobiernos e instituciones de los Estados y países tienen como misión fundamental buscar el bienestar de la ciudadanía sin distinciones. Uno de los problemas que a menudo surge es asegurar la equidad en el acceso a todos los bienes y servicios que, de forma global, los estados deben garan­tizar. Uno de los impedimentos más esgrimidos es la desigual distribución territorial del tipo de actividad de cada zona o región. Con el fin de gestio­nar y administrar estos desequilibrios se han de llevar a cabo una serie de acciones de reequilibrio territorial. Para ello se presenta una metodología, basada en el modelo de los efectos olvidados Kaufmann y Gil Aluja, 1988, en la que se constata y se cuantifica la relación existente entre el tipo de actividad económica de un territorio y la calidad de vida de los ciudadanos que lo habitan. El objetivo es ofrecer un modelo para la toma de decisiones en torno a las políticas de inversión territorial de los estados con el fin de que toda la ciudadanía goce del mismo nivel de bienestar, sea cual sea la zona o región en la que habite.
ALGUNOS FACTORES A CONSIDERAR EN LAS PYMES POR EFECTO DEL CAMBIO CLIMATICO, REGIÓN CENTRO DEL ESTADO DE COAHUILA
Authors: Zúñiga Cortez Juan Hermilo , González Guajardo Jesús Emilio , Gutiérrez González Leonor , Morales Tovar Esmeralda Citlalin
Published: April 2023

No cabe duda que el cambio climático a través del tiempo forma parte del desarrollo empresarial derivado del posible impacto en la gestión, por lo que el objetivo de este trabajo es comprobar si el cambio climático es tomado en cuenta por la Pyme como variable en la gestión del negocio, la validez se realizó con el método de expertos, y la fiabilidad con Alpha de Cronbach .814 siendo aceptable este resultado, las empresas que sobresa­len son las comerciales 50%, casi cien por ciento de las Pymes (97%) son Sociedades Anónimas de capital variable, 90% tienen el cien por ciento de las acciones y el 90% con más de 20 años de operación, el nivel académico de los administradores es nivel Licenciatura, la validez de la hipótesis es con Análisis Factorial explicando el fenómeno con seis factores con un 89.087% para cumplir con el requisito del análisis factorial para estas in­vestigaciones, generando nuevos constructos. Concluyendo que la mayo­ría de las empresas no toman en cuenta el clima como variable así como algunos factores que afectan el medio ambiente y el modelo de gestión empresarial actual, por lo que se deben considerar nuevas estrategias para minimizar los impactos en la empresa.
Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells
Authors: Jia Yannan , Han Lina , Ramage Cassandra L. , Wang Zhe , Weng Connie C. , Yang Lei , Colla Simona , Ma Helen , Zhang Weiguo , Andreeff Michael , Daver Naval , Jain Nitin , Pemmaraju Naveen , Bhalla Kapil , Mustjoki Satu , Zhang Peiyi , Zheng Guangrong , Zhou Daohong , Zhang Qi , Konopleva Marina
Published: April 2023

BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-XL and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCLX L/BCL-2 ubiquitination and degradation selectively in cells expressing VHL. Because platelets lack VHL expression, 753B spares on-target platelet toxicity caused by the first-generation dual BCL-XL/BCL-2 inhibitor navitoclax (ABT-263). Here, we report pre-clinical single-agent activity of 753B against different leukemia subsets. 753B effectively reduced cell viability and induced dose-dependent degradation of BCL-XL and BCL-2 in a subset of hematopoietic cell lines, acute myeloid leukemia (AML) primary samples, and in vivo patient-derived xenograft AML models. We further demonstrated the senolytic activity of 753B, which enhanced the efficacy of chemotherapy by targeting chemotherapy-induced cellular senescence. These results provide a pre-clinical rationale for the utility of 753B in AML therapy, and suggest that 753B could produce an added therapeutic benefit by overcoming cellular senescence-induced chemoresistance when combined with chemotherapy.
DA DITADURA MILITAR À REDEMOCRATIZAÇÃO: CAMINHOS DA TEORIA HISTÓRICO-CULTURAL NA PSICOLOGIA E EDUCAÇÃO BRASILEIRAS (ANOS 1970 A 1990)
Authors: Toassa Gisele , Da Silva Ferreira Asbahr Flávia , Proença Rebello de Souza Marilene
Published: April 2023

O presente artigo traça uma breve análise histórica do processo inicial de apropriação e difusão da psicologia histórico-cultural no Brasil, com foco no legado de Lev Semionovich Vigotski (1896-1934). O objetivo da pesquisa que lhe deu origem foi identificar especificidades do contexto político brasileiro e seu desdobramento no trabalho dos grupos que impulsionaram esse processo de difusão. Para tanto, trabalhamos com teses, livros, artigos e dossiês que recuperam a história do legado vigotskiano entre os anos 1970 (ainda durante a ditadura civil-militar) e final da década de 1990. Nossa análise mostra o decisivo impacto da redemocratização na busca por referências mais adequadas à realidade brasileira (seja na educação ou na psicologia social), com ênfase no marxismo, assim como o redesenho das políticas educacionais no bojo da redemocratização que atravessou os anos 1980 e 1990 e que acabou promovendo Vigotski à condição de um dos mais populares autores da psicologia no campo educacional em nosso país. Concluímos nosso percurso apontando como essa popularidade desdobra-se no bojo de divergências sobre a natureza política e epistemológica do seu legado.
Palavras-chave: Vigotski, Lev Semionovich (1896-1934); psicologia educacional; psicologia histórico-cultural; redemocratização; história da psicologia.
 
ABSTRACT
This article outlines a brief historical analysis of the initial process of appropriation and diffusion of historical-cultural psychology in Brazil, focusing on the legacy of Lev Semionovich Vigotski (1896-1934). The objective of the research that gave rise to it was to identify specificities of the Brazilian political context and its unfolding in the work of the groups that boosted this diffusion process. To do so, we work with theses, books, articles and dossiers that trace the history of the Vygotskian legacy between the 1970s (still during the civil-military dictatorship) and the end of the 1990s. Our analysis highlights how the search for more appropriate references to Brazilian reality (whether in education or in social psychology), with an emphasis on Marxism, played a significant role in such legacy. This process also depended on the reshaping of educational policies in the wake of redemocratization that went through the 1980s and 1990s and ended up promoting Vygotsky to the status of one of the most popular psychology authors in the educational field in our country.  We conclude our journey by pointing out how this popularity unfolds in the midst of disagreements about the political and epistemological nature of his legacy.
Keywords: Vygotsky, Lev Semionovich (1896-1934); educational psychology;  historical-cultural psychology; redemocratization; history of psychology.
A fisioterapia no pós-operatório de cirurgias conservadoras de câncer de mama: revisão bibliográfica
Authors: Soares Antoniel de Oliveira , Limão Emmanuel Victor Morais , Souza Kaylane Rodrigues de
Published: April 2023

O câncer de mama ocupa a segunda posição entre os tipos de câncer mais comum no mundo, sendo ele mais corriqueiro entre as mulheres e sua incidência vem aumentando ao longo do tempo, deste modo, a fisioterapia vem para somar nesse processo de tratamento pós-operatório do câncer de mama, a fim de melhorar a qualidade de vida das pacientes. O objetivo desse trabalho é analisar a vista fisioterapêutica no pós-operatório de pacientes com câncer de mama, a fim de expor formas para melhorar a qualidade de vida das pacientes e mostrar a importância da fisioterapia no meio oncológico que cresce a cada dia mais, através de uma revisão bibliográfica. A presente revisão de literatura constitui-se de uma pesquisa de caráter exploratório-descritivo. Para construção de referencial teórico, foram buscados bancos de dados de publicações científicas em bases eletrônicas de domínio público online, tais como PubMed, SciElo, e Science Direct. Foram selecionados artigos científicos de acesso livre nas línguas portuguesa e inglesa, pesquisados no período de 20/06/2022 a 9/10/2022. Não há um consenso sobre a amplitude de movimento do ombro nos primeiros dias de pós-operatório, assim existem diferentes formas de reabilitação para esses pacientes submetidos a cirurgias conservadoras na neoplasia maligna de mama e desse modo intervi as possíveis complicações causadas por esse procedimento. Com base nos artigos estudados a fisioterapia se mostrou muito importante para essas pacientes submetidas a essas cirurgias que claramente interfere no bem-estar, autoestima e psicológico.
Aspectos fisiopatológicos da emergência hipertensiva e conduta na emergência: uma revisão narrativa
Authors: Frazão Luiz Felipe Neves , Santos Antônio José Coimbra dos , Helbingen Vitor Xavier , Temponi Murilo Santos , Sousa Júnior Joel Alves de , Puglia Ana Clara , Morais Vitória Cordeiro , Miranda Yasmin Cruvinel Vieira de , Silva William Gomes da , Maia Pétala Diane Koster , Rosa Francielle Andrade Carvalho , Silva Ronny de Tarso Alves e , Monteiro Vanessa Borges
Published: April 2023

Definida como uma emergência hipertensiva (EH) tendo como característica a elevação acentuada e aguda da pressão arterial, em específico a diastólica, estando maior que 120 mmHg, associada a sinais de lesão de órgão-alvo. Estes podem incluir edema pulmonar, isquemia cardíaca, déficits neurológicos, insuficiência renal aguda, dissecção aórtica e eclampsia. Diante da importância epidemiológica da EH este artigo visa discutir os mecanismos fisiopatológicos da doença. Este estudo trata-se de uma revisão narrativa com o propósito de discutir e descrever sobre a EH e sua fisiopatologia, como também, demonstrar como esta doença afeta a vida pessoal dos indivíduos acometidos. Foi utilizado o banco de dados: SciElo (Scientific Eletronic Library Online) e PubMed (US National Library of Medicine), com dados científicos de 09 de março de 2023, sem restrição de idioma e sem restrição ao ano de publicação. Vários estudos mostram a fisiopatologia da EH, onde inclui condições associadas ao aumento do volume intravascular, da resistência vascular periférica e, também, a possibilidade da produção reduzida de vasodilatadores endógenos que podem levar a vasorreatividade maior que é capaz de gerar a emergência. Em suma, a sepse continua sendo um fardo significativo para os sistemas de saúde em todo o mundo.
Cuidados paliativos odontológicos a pacientes com câncer bucal
Authors: Soares Larissa Silva , Silva Gabriela Gonçalves da , Guedes Cizelene do Carmo Faleiros Veloso
Published: April 2023

Sabe-se que a qualidade da saúde bucal do indivíduo é extremamente importante, devendo-se prevenir contra prejuízos futuros como doença periodontal e cáries recorrentes. Indivíduos que se encontram em tratamentos oncológicos paliativos, apresentam vários problemas sistêmicos. O objetivo do trabalho é ressaltar a importância dos cuidados paliativos odontológicos em pacientes com câncer bucal, tanto para os pacientes como familares. Trata-se de uma revisão narrativa de literatura descritiva e qualitativa disponíveis nos bancos de dados online PubMed, Google Acadêmico, Scielo e Lilacs e foram selecionados artigos publicados entre 2005 a 2022 na língua portiguesa e iglesa.  Doenças orais, tais como xerostomia, candidíase e estomatite possuem alta prevalência em pacientes portadores de doenças graves, as quais podem gerar complicações e comprometimento da qualidade de vida desses pacientes. Por este motivo é de extrema importância os cuidados por parte dos cirurgiões dentistas, pois a saúde bucal do indivíduo, afeta a condição sistêmica, principalmente em pacientes paliativos. Os cuidados paliativos busca proporcionar uma melhor qualidade de vida tanto para os pacientes com doença avançada quanto dar suporte para seus familiares durante o período que for necessário. Conclui-se, assim que os cuidados paliativos são de extrema importância para pacientes oncológicos, independente se estes se encontram em ambiente hospitalar ou não.
Berberina: aspectos químicos, farmacológicos e sua potencial relação profilática com a doença de Alzheimer
Authors: Freitas Samuel Rodrigues do Nascimento , Silva Thiago Filipe da , Rodrigues Jefferson Renan Pinheiro , Araújo Victória Raquel Alves de , Ramos Alexsandra Andreia da Silva , Silva Ivini Ferreira da , Silva Nataly Juliany da , Sousa Danielly Gonçalo da Silva , Lima Caique Derwsom Oliveira de
Published: April 2023

Este artigo objetivou revisar os aspectos químicos e farmacológicos da berberina, correlacionando-os com a desfecho fisiopatológico da doença de Alzheimer (DA). Foi realizado um estudo descritivo do tipo revisão narrativa de literatura. O lócus investigativo se deu mediante busca eletrônica nas bases Scientific Eletronic Library (SciELO), Centro Latino-americano e do Caribe de Informação em Ciências da Saúde (BIREME-OPAS-OMS) e National Library of Medicine, dos EUA (PubMed), sendo considerados os artigos publicados entre 2018 e 2023, no idioma inglês, português e espanhol. A busca dos artigos se deu a partir da pesquisa das palavras-chave berberine e Alzheimer disease, usando-se o operador booleano and para conectar esses termos. A berberina é classificada como um sal de amônio quaternário, faz parte do grupo de alcaloides isoquinolínicios denominado protoberberina. Alguns estudos apontam que a berberina é capaz de atenuar o processo inflamatório, a excitotoxicidade, a atividade excessiva de radicais livres e deposição de placas senis. Esta revisão resumiu os aspectos químicos e físico-químicos da berberina, relacionando-os com parâmetros de biodisponibilidade; elucidou alguns pontos da etiologia, da fisiopatologia e das manifestações clínicas da doença de Alzheimer, considerando sua complexidade; e correlacionou-os considerando os principais mecanismos de ação da neuroprotetora substância. Os estudos in vivo e in vitro demonstram que a berberina possui potencial terapêutico para o tratamento da doença de Alzheimer. Entretanto, ainda não é possível afirmar se esses resultados são translacionais. Para comprovar sua eficácia em humanos e estimar possíveis doses terapêuticas se faz necessário estudos clínicos robustos.
Enhanced geranylgeraniol stability and dissolution from self-emulsifying pellets containing the sucupira (Pterodon emarginatus Vogel) standardized extract
Authors: Alves Suzana Ferreira , Marreto Ricardo Neves , Bara Maria Teresa Freitas
Published: April 2023

The vegetal species sucupira (Pterodon emarginatus Vogel) presents some diterpenes that have anti-inflammatory activities. However, diterpenes are poorly water-soluble compounds. The development of Self-Emulsifying Drug Delivery Systems (SEDDS) allows for obtaining a solid dosage form that maximizes the release of P. emarginatus constituents in an aqueous medium. This work aimed to obtain and characterize pellets containing the SEDDS prepared from P. emarginatus extract using the extrusion-spheronization technique. Formulations PF1 to PF6 were tested. Then, self-emulsifying formulations were prepared (SES1 to SES5) based on the mixture of poloxamer 188 (Pluronic® F-68) and sorbitan triolate (Span®85) with P. emarginatus extract. Next, formulation PF6, containing microcrystalline cellulose: P. emargitus extract: aerosil®200: polyvinylpyrrolindone K-30 (50: 54.25: 4: 4) was used in the preparation of pellets containing the self-emulsifying systems. These pellets had a homogeneous surface and average sphericity of 0.52. When encapsulated in hard gelatin capsules, it was noted that the formulations PF6, PSES3 and PSES4 were statistically different from each other at the 5% level. In the first 10 min of dissolution, PSES3 and PSES4 showed a higher level of geranylgeraniol released compared to the PF6 (p=0.000117). However, after 20 min of dissolution, no significant difference was observed in relation to the content of this compound. In the accelerated stability study, the average content of the geranylgeraniol was 85.6% and 81.8% for PSES3 and PSES4, respectively, whereas it was only 34.4% for PF6. Under the studied conditions, obtaining the self-emulsifying systems made it possible to achieve the desired dissolution and chemical stability of geranylgeraniol.
Medyada Şiddet Kültürü: Prof. Dr. Ömer Özer ile Söyleşi
Authors: BAŞPEHLİVAN Atakan
Published: April 2023

Medyada Şiddet Kültürü: Prof. Dr. Ömer Özer ile Söyleşi
El trasplante de progenitores hematopoyéticos y la terapia celular
Authors: Maldonado Guerrero Bella
Published: April 2023

El trasplante de progenitores hematopoyéticos se ha convertido en una opción curativa y de sobrevida libre de enfermedad que las alcanzadas con otras modalidades terapéuticas en ciertas patologías congénitas o tumorales. A inicios del año 2006 se diseñó el proyecto para la creación de la Unidad de Trasplante de progenitores hematopoyéticos del Hospital de SOLCA – Guayaquil. En Junio de 2006, la Unidad de Trasplante de Médula Ósea (UTMO) inicia los primeros trasplantes, uno autólogo y otro alogénico, y a partir de entonces se han realizado 375 trasplantes de progenitores hematopoyéticos, de los cuales 166 han sido de tipo alogénicos, 147 con progenitores hematopoyéticos obtenidos desde la sangre periférica o médula ósea propiamente dicha y 19 con células obtenidas desde la sangre de cordón umbilical, así como 209 trasplantes de tipo autólogo. Atualmente se ha diseñado un proyecto de ampliación que contempla una infraestructura con 20 habitaciones para hospitalización y un área para manipulación celular más amplia con equipamiento complementario, lo cual permitirá incrementar la cartera de servicios, a saber: la opción del trasplante alogénico de tipo haploidéntico y ciertos procedimientos de inmunoterapia adoptiva con células T.
Мethod of diagnosis of modern tractor diesels of agricultural purpose
Authors:   University of Warmia and Mazury in Olsztyn, Vrublevskyi Oleksandr , Gonera Jarosław ,   University of Warmia and Mazury in Olsztyn, Prokhorenko Andriy ,   Kharkiv National Automobile and Highway University, Kuzmenko Anatoliy ,   Kharkiv National Automobile and Highway University
Published: April 2023

The paper presents new the latest method of diagnostics of a diesel engine of an agricultural tractor based on the analysis of data on changes in efficiency and parameters that characterize the process of formation of fuel-air mixture generated by the engine controller. The technique was tested using an original test cycle, during which several engine defects were physically simulated, which led to changes in the conditions and quality of the processes of formation and combustion of the fuel-air mixture. The paper substantiates the choice of operating modes and a set of engine parameters that provide the greatest information and allow you to effectively identify possible damage. The developed technique and the obtained results allow to determine the technical condition of the engine directly in the operating conditions, both for vehicles with a driver and for unmanned vehicles. Keywords: diagnostics, internal combustion engine, damage, fuel consumption, efficiency, test cycle.
Availability of general purpose buses for passengers with limited mobility
Authors:   SE “State Road Transport Research Institute”, Zelinsky Evgeniy , Lapshin Yriy ,   SE “State Road Transport Research Institute”, Lych Vasyl ,   SE “State Road Transport Research Institute”
Published: April 2023

The issue of creating appropriate conditions for the access of people with limited mobility to public transport (general buses) has been disclosed; the creation of a civilized society in Ukraine, the purpose of which is to achieve the full participation of people with limited mobility in public life; ensuring the unimpeded use of buses on public routes by persons with reduced mobility. Keywords: general purpose bus, public routes, classes of buses, passenger with reduced mobility, priority passenger, wheelchair, pram, lift, ramp, supporting plate.
Impact of road transport vehicles on climate change while using traditional and alternative fuels
Authors:   Kharkiv National Automobile and Highway University, Volkov Vladimir , Vnukova Nataliia ,   Kharkiv National Automobile and Highway University, Pozdnyakova Olena ,   Kharkiv National Automobile and Highway University
Published: April 2023

The purpose of the work was to identify environmental climatic impacts resulting from the biodiesel fuel use for vehicles (Vs). The methods are based on computation of natural resource consumption and toxic substances emission with the help of environmental footprint calculator being a software program. The results of integral assessment of the environmental impact (namely, consumption of water, pow basic traction trucks as VOLVO FM, FH, FE, and FL) were computed for biodiesel fuel types В0, В7, В30, В100 depending upon different standards of EURO propellants. Both positive and negative environmental impact factors have been determined for consuming biofuels during full lifecycle of Vs. It has been defined that minor decrease in СО2 emission owing to the use of standard modern biodiesel fuel was followed by significant increase in NOx emission, as well as power and water consumption in terms of first-generation biodiesel fuel utilization. Similar tendencies were recognized. Moreover, opportunity to apply biodiesel fuels along with other measures decreasing СО2 emission was analyzed. Originality it is stipulated by the use of the integrated assessment of impact of vehicles on climate change, as well as the use of natural resources while applying biodiesel fuel for vehicles. Keywords: greenhouse effect, biodiesel fuel, life cycle of Vs, nitrogen oxides.
FAMÍLIAS EM FOCO: ESTUDO DAS FOTOPINTURAS ATRAVÉS DE DISCURSOS IMAGÉTICOS NO CENTRO DO PARANÁ
Authors: Guimaraes Valdir Machado
Published: April 2023

Este artigo que se propõe, versa sobre a questão da visualidade dos retratos de famí­lias na região central do Paraná. Para este fim selecionamos como objeto de análise as fotopinturas, imagens com aplicações de tintas que apresentam casais como foco de suas representações. Esta problemática procura discussões frente aos referenciais teóricos, podendo contribuir para pesquisas que tratam destas fontes, na compreensão de suas práticas culturais, sendo relevante para os estudos históricos. Para este fim, selecionamos algumas fontes que permitem refletir frente aos diálogos com a dimensão visual, percebendo suas articulações dentro da historiografia que trata de fotografias.