bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern Tools for the Development of Public Spaces and their Role in the Development of Tourism
Authors:   Peoples Friendship University of Russia named after Patrice Lumumba, Olshanskaya M. V.
Published: September 2024

Currently, public spaces are just beginning to be considered as an object of research in the field of regional economics. Public spaces increasingly determine the image of the urban environment, the comfort of living and the attractiveness of the territory for one-time visits. It is possible to increase the tourist attractiveness of the region by forming an attractive appearance of public spaces of the urban conglomeration. Little attention to the design of public spaces has led to the fact that many newly erected construction projects in Russian cities have a “faceless”, industrial image, unattractive in terms of both permanent residence and visits for tourist pur-poses. This approach is strategically not justified and does not meet modern requirements. The article studies modern approaches to the development of public spaces that correspond to the state of the external environment. The work revealed the place of public spaces in the develop-ment of the tourism industry in the Russian Federation. In the course of the study, it was proved that the design of public spaces can become a tool for the development of tourism and increasing the competitiveness of the territory in the tourism industry. The formation of public spaces makes it possible to solve the tasks set in the Strategy for the Development of Tourism of Russia: in-crease the competitiveness of a tourist product, develop cultural and educational space, business tourism, use an integrated approach to the development of tourism, etc. Such tools for the for-mation of public spaces have already been tested and successfully used: temporary architectural forms, geoplastics; gastro quarters; participatory design, digital means of sup-porting the ecosys-tem of public spaces.
RESULTS OF DIFFERENT PLANT PROTECTION MEANS AGAINST CODLING MOTH IN APPLE PLANTATIONS
Authors: Кочкина А.М. , Каширская Н.Я.
Published: September 2024

В условиях ЦЧР отмечено увеличение численности и вредоносности яблонной плодожорки, которая является основным вредителем в период роста и созревания плодов. Инсектициды широкого спектра действия следует заменять высокоселективными препаратами, которые избирательно действуют на  вредные объекты и  являются малоопасными для полезных элементов агробиоценоза и окружающей среды. В 2019–2021 гг. были выполнены исследования в насаждениях яблони ФГБНУ «ФНЦ им. И.В. Мичурина» на сорте Богатырь. Краткосрочный прогноз сроков проведения защитных мероприятий осуществляли на  основе подсчёта суммы эффективных температур и  наблюдениями за  началом массового лёта бабочек первого и второго поколений с помощью использования феромонных ловушек. Биологическая эффективность препаратов из  группы регуляторов роста и  развития насекомых (кораген, герольд, атаброн) колебалась в  пределах 94–98%. Использование препаратов из группы регуляторов роста и развития насекомых наряду с авантом, КЭ (0,35 л/га) в период начала отрождения личинок и калипсо, КС (0,4 л/га), обладающего пролонгированным действием против яблонной плодожорки обеспечивает эффективность до 97%.

An  increase in  number and harmfulness of  codling moth is observed in the Central chernozem region where the moth is the main pest during the growing season and fruit ripening. Broad spectrum insecticide should be replaced by highly selective chemicals which act selectively on objects and are not so dangerous for useful elements of agrobiocenosis and environment. The investigations of  2019–2021  were carried out in  apple plantations of the FSSI “I.V. Michurin FSC” on Bogatyr variety. Short term forecast of the seasonal procedures for plant protection was carried out on the base of calculation of the effective temperatures sum and observation of initiation of mass moth spread of the first and second generation with the use of pheromone traps. Biological efficiency of chemicals from the group of the growth regulators and pest management (coragen, gerold, atabron) varied within 94–98%. The use of such preparation together with avant, CE ( 0,35 l/ha ) in the period way out of larvae and calypso, CS (0,4 l/ ha) having long-term effect against codling moth provide the effective to 97%.
REACTION OF APPLE TREE PLANTS TO TRANSFORMATION WATERTEMPERATURE REGIME OF THE CENTRAL CHERNOZEM REGION
Authors: Цуканова Е.М. , Ткачев Е.Н.
Published: September 2024

Приведены результаты подробного анализа температурного и  водного режима Центрального Черноземья на  последние 25  лет. Выявлены существенные изменения температурных и  влажностных характеристик территории. Круглогодичное изучение реакции плодовых растений на стрессоры гидротермического режима позволило установить наиболее уязвимые периоды в  годичном цикле их  развития и  закономерности реакции обменных систем на  воздействие стрессоров. Выявлены существенные изменения длительности периода и сроков вхождения и выхода растений яблони в состояние глубокого покоя  — отмечен не  только ранний выход растений из  состояния глубокого покоя (уже в  середине  — конце декабря), но и значительное сокращение этого периода.

The results of a detailed analysis of the temperature and water regime of the Central Black Earth Region for the last 25 years are presented. Significant changes in the temperature and humidity characteristics of the territory were revealed. Year-round study of  the response of  fruit plants to  stressors of the hydrothermal regime made it possible to establish the most vulnerable periods in  the annual cycle of  their development and the patterns of  reaction of  metabolic systems to  the influence of stressors. Significant changes in the duration of the period and timing of the entry and exit of apple tree plants into a state of deep dormancy were revealed  — not only an  early exit of  plants from a state of deep dormancy was noted (already in the middle — end of December), but also a significant reduction in this period.
The diffusion of tempone spin probe in poly-D,L-lactide and polymethylmethacrylate plasticized with sub- and supercritical carbon dioxide
Authors: Попова А.А. , Голубева Е.Н.
Published: September 2024

Методом ЭПР оценены коэффициенты вращательной и трансляционной подвижности спинового зонда ТЕМПОН в полилактиде (ПЛА) и полиметилметакрилате (ПММА), пластифицированных сверх(СК)- и суб(СУБ)-критическим СО2. Коэффициенты трансляционной диффузии ТЕМПОН в системе ПММА-СК-СО2, на три порядка меньше, чем в ПЛА-СК-СО2, и имеют значения порядка 10-4 и 10-11 м2/с соответственно. Энергия активации вращения ТЕМПОН в ПЛА-СК-СО2 составляет 22 ± 5 кДж/моль. При импрегнации ПЛА зондом в субкритических условиях на протяжении всего эксперимента преимущественной является десорбция радикала. Спектр ТЕМПОН в ПЛА-СУБ-СО2 представляет собой суперпозицию узкого сигнала, аналогичного спектру ТЕМПОН в ПЛА-СК-СО2, а также широкого изотропного сигнала, вызванного магнитным концентрированием зондов ТЕМПОН в приповерхностном слое полимера. Снижение локальной концентрации со временем сопровождается появлением вращательной анизотропии в спектрах частиц второго типа. Полученные результаты свидетельствуют о преимуществах использования СК-СО2, как растворителя для импрегнации полимеров, обусловленных, прежде всего, высокими значениями коэффициентов диффузии.

The rotational and translational coefficients of the TEMPONE spin probe mobility were studied by ESR spectroscopy in the PLA and PMMA-based polymers plasticized with supercritical as well as subcritical carbon dioxide. Translational diffusion coefficients of TEMPONE in the PMMA-SC-CO2, system are 3 times inferior in comparison to PLA-SC-CO2  and the corresponding values are of 10-14 and 10-11 m2/s order of magnitude. The rotation activation energy of a value 22±5 kJ/mole was determined for the TEMPONE rotation in PLA-SC-CO2. It was found out that desorption of the radical exceeds TEMPONE diffusion into bulk PLA under subcritical conditions during the experimental period. Spectra of TEMPONE in PLA-SUB-CO2 turned out to be a superposition of two signals: a narrow one, which is similar to that of TEMPONE in PLA-SC-CO2, and a broad isotropic one caused by the TEMPONE paramagnetic particles accumulation in a polymer volume proximate to the surface. As local concentration decreases with time, the rotational anisotropy is exposed in the latter signal. The study gives an outlook on the SC-CO2 use as promising media to the polymer impregnation primarily taking into consideration both it’s and solutes’ higher mass diffusivity.
Some methodological aspects of solid phase–supercritical fluid equilibria modeling
Authors: Восков А.Л. , Демченко А.М. , Иванов А.С. , Лоскутова С.П. , Константинова Н.М. , Воробей А.М. , Костенко М.О. , Паренаго O.O.
Published: September 2024

Термодинамическое моделирование растворимости фармпрепаратов в сверхкритических флюидах необходимо для  оптимизации процессов экстракции, очистки, микронизации и т. п. В работе на примере тройных систем СО2—этанол—аспирин и СО2—диметилсульфоксид (DMSO)—сульфат сальбутамола показана возможность использования для этих целей упрощенных моделей на основе кубического уравнения состояния Пенга—Робинсона. В нем описаны фазовые равновесия в двойных системах СО2—этанол при р = 0,1—12 МПа и Т= 290—345 К, а также СО2— DMSO при р = 0,5—18 МПа и Т= 275—50 К. В случае тройных систем успешно аппроксимированы данные по растворимости фармпрепаратов в смешанных растворителях. Для аспирина использовали имеющиеся экспериментальные данные при р = 7,5—35 МПа, Т = 298—328 К, х(С2Н5ОН) =  0 и 3 мол. %. Растворимость сульфата сальбутамола в смеси СО2 и DMSO была измерена визуально в термостатируемой ячейке постоянного объема при р = 8,6—21,7 МПа и Т= 313—323 К. Хотя построенные модели описывают фазовые равновесия, они не согласуются с данными по плотности флюида, особенно для богатых полярными компонентами составов. Однако, это не препятствует использованию кубических уравнений состояния для описания растворимости фармпрепаратов во флюидных системах.

Thermodynamic modeling of pharmaceutical drugs solubility in supercritical fluids is necessary of optimization of extraction, purification, micronization and other processes. The CO2-ethanol-aspirin and CO2—dimethylsulfoxide (DMSO)—salbutamol sulfate ternary systems were used to show possibility of application of simplified models based on Peng—Robinson cubic equation of state. They were used for descri ption of phase equilibria in the CO2—ethanol binary subsystem at p=0.1—12 MPa and T = 290—345 K and in the CO2—DMSO binary subsystem at p = 0.5—18 MPa and T = 275—350 K. In the case of ternary systems, the data on the pharmaceuticals solubility in the mixed solvents were successfully approximated. Existing data at p = 7.5—35 MPa, T = 298—328 K, x(C2H5OH) = 0 and 3 mol. % were used for aspirin. Salbutamol sulfate solubility in the CO2—DMSO mixture was measures in this work at p = 8.6—21.7 MPa and T = 313—323 K by means of visual method in the thermostatic cell of constant volume. Although the obtained models describe phase equilibria, they disagree with fluid density data, especially for composition that are rich with polar components. Nevertheless, it doesn’t cause problems with usage of cubic equations of state for description of pharmaceuticals solubility in the fluid-based systems.
PHASE EQUILIBRIA IN THE SYSTEM ND3 -WATER-NITRIC ACID--TODGA-CO2 AND THE EFFICIENCY OF SUPERCRITICAL FLUID EXTRACTION OF NEODYMIUM IONS
Authors: ЗУЕВ Я. И. , КОСТЕНКО М. О. , СИНЁВ М. Ю. , ПАРЕНАГО О. О. , БАРАНОВСКАЯ В. Б.
Published: September 2024

Изучены некоторые равновесия в системе Nd3+-вода-азотная кислота-ТОДГА- CO2 (ТОДГА - N,N,N',N'-тетраоктилдигликольамид, или тетра-н-октиламид дигликолевой кислоты) и эффективность экстракции ионов Nd3+ из водных растворов в фазу сверхкритического (СК) CO2 при 313-353 К и 18,0-40,0 МПа. Показано, что в отсутствие ТОДГА переход ионов Nd3+ в СК-фазу не происходит. Эффективность экстракции возрастает при снижении температуры и с увеличением концентрации азотной кислоты (САК) в водном растворе. При 313 К, САК > 1,5 моль/л, содержании ТОДГА не менее 100 моль/г-ат. Nd и давлении CO2, обеспечивающем полное растворение ТОДГА (> 19,0 МПа), наблюдается полный переход Nd3+ в СК-фазу. С ростом содержания в системе ионов неодима происходит увеличение давления и количества CO2, необходимое для полного растворения ТОДГА. Это связано, по-видимому, со снижением интенсивности межмолекулярных взаимодействий в СК-фазе при переходе в нее полярных комплексов Nd с ТОДГА и нитрат-ионами.

Some equilibria in the system Nd3+-water-nitric acid-TODGA-CO2 (TODGA - N,N,N',N'-tetraoctyl diglycolamide) and the efficiency of extraction of Nd3+ ions from aqueous solutions into the supercritical (SC) CO2-based phase at 313-353 K and 180-400 bar were studied. It has been shown that in the absence of TODGA, the transfer of Nd3+ ions to the SC-phase does not occur. The extraction efficiency increases with decreasing temperature and with increasing concentration of nitric acid (CNA) in the aqueous solution. At 313 K, CNA ≥ 1.5 mol/l, TODGA content not less than 100 mol/g-at. Nd and CO2 pressure ensuring complete dissolution of TODGA (> 19 MPa), a complete transfer of Nd3+ to the SC-phase is observed. As the content of neodymium ions in the system increases, the pressure and amount of CO2 required for complete dissolution of TODGA increases too. This is apparently due to a decrease in the intensity of intermolecular interactions in the SC-phase at increasing concentration in it of large and polar Nd complexes with TODGA and nitrate ions.
A Scale Development and Application Study on Smartphone Security Awareness
Authors: Yıldırım Mevlüt , Demirer Veysel
Published: September 2024

This study aims to assess the extent of smartphone security awareness among students pursuing an associate degree and to ascertain if there are substantial variations in smartphone security awareness based on certain demographic variables. Furthermore, its objective is to uncover the correlation between smartphone security awareness and proficiency in digital literacy. The Smartphone Security Awareness Scale was initially designed with this particular aim. The scale comprises nine items that are measured along a single dimension, accounting for 39.6% of the overall variation. The scale’s reliability coefficient was found to be 0.78. The study sample comprised 612 associate degree students pursuing further education in two vocational colleges. The data were obtained using the internet and voluntarily. The data indicate that associate degree students had a high level of awareness regarding smartphone security. There was no significant difference in smartphone security awareness based on gender, use of security software, participation in information security training, and level of care regarding the privacy and safeguarding of personal data. No significant relationship was found between smartphone security awareness and smartphone ownership duration. However, significant differences were found according to experience of security problems and competence in using information technologies. A positive, significant, and moderate correlation was discovered between smartphone security awareness and proficiency in digital literacy. The scale devised during the investigation can be utilised in other future studies. According to the results obtained in this direction, training and seminars can be organised to increase smartphone security awareness.
El trabajo geométrico de niñas y niños ciegos al resolver problemas con cuadriláteros
Authors:   , Correa Pablo Ariel
Published: September 2024

En este estudio se explora el aprendizaje de la geometría en el estudiantado ciego. El objetivo general de la investigación consiste en relevar y analizar los conocimientos y los procedimientos de resolución que emplean niñas y niños ciegos al resolver problemas geométricos que involucran propiedades de los cuadriláteros, uno de los contenidos centrales de la enseñanza de la geometría en el segundo ciclo de la escuela primaria. Metodológicamente se entrevistaron a una niña y un niño ciegos mientras resolvían una secuencia de problemas geométricos diseñada específicamente para esta investigación. Para su elaboración, se siguieron algunas de las fases que propone la metodología de la Ingeniería Didáctica (Artigue, 1995). La enseñanza de la geometría suele estar acompañada por prácticas que se apoyan predominantemente en la percepción visual, lo que lleva a suponer, a quienes desconocen el objeto de estudio de esta disciplina, que el alumnado ciego no podría acceder a esta área de conocimiento. Sin embargo, la Didáctica de la Matemática nos enseña, al igual que la geometría misma en su evolución, que la actividad geométrica no es necesariamente empírica ni visual, sino intelectual. Esto, junto a los aportes de la Educación Inclusiva, nos insta a considerar recursos y construir apoyos que faciliten el acceso del estudiantado al trabajo intelectual propio de este recorte de saber, incluyendo a las alumnas y los alumnos ciegos. Es en este sentido que la indagación también recupera aportes de la Psicología del Tacto. La investigación detalla el desarrollo de la secuencia didáctica con énfasis en los procesos de construcción de conocimientos geométricos que niñas y niños ciegos producen en interacción con los problemas, los materiales y las intervenciones didácticas.
Analysis of Customer Experience and Customer Satisfaction on Repurchase Intention with Customer Loyalty as a Mediation Variable at Cafe Dokobox Mamuju
Authors: Wardani Rezki , Wiyadi Wiyadi , Soepatini Soepatini , Nasir M.
Published: September 2024

This article discusses customer experience and customer satisfaction regarding repurchase interest at Cafe Dokobox Mamuju, with customer loyalty as a mediating variable. This research used a questionnaire to collect data from 200 customers and analyzed using SmartPLS 3. The results show that customer experience and customer satisfaction have a significant influence on loyalty, customer experience also influences repurchase intention. However, customer loyalty does not mediate the influence of customer experience and satisfaction on repurchase intention.
The Influence of Transformational Leadership on Employee Motivation and Performance in the Banking Industry
Authors: Oroh Oliviane , Yusuf Ariyadi Muhammad , Fauzan Fadlan A.
Published: September 2024

This study analyzes the effect of transformational leadership on employee motivation and performance in the banking industry. The research method used is quantitative with a survey approach, involving 200 employees from several leading banks in Indonesia. Data were collected through a questionnaire that measured the respondent's profile, perceptions of transformational leadership, and employee motivation and performance. The results showed that transformational leadership has a significant positive effect on employee motivation and performance. Characteristics of transformational leadership such as charisma, intellectual stimulation, inspirational motivation, and individual consideration increase intrinsic motivation and employee performance. Employees feel appreciated, have challenging tasks, and get significant career development opportunities. This study concludes that transformational leadership can provide a significant competitive advantage for banking companies by increasing employee motivation and performance. Therefore, banking companies are advised to adopt and develop this leadership style in order to achieve long-term success.
EVALUATION OF STUDENTS ATTITUDES AND PERCEPTIONS ABOUT ARTIFICIAL INTELLIGENCE IN DENTISTRY
Authors: Jain Anushka , Thakur Seema , Singhal Parul
Published: September 2024

Background & objectives: The adoption of articial intelligence in healthcare marks signicant change, yet there exists a disparity in how dental
students perceive and approach these emerging technologies. The present study was conducted with the objective to evaluate attitudes and
perceptions of students by sex and academic year regarding the use of articial intelligence (AI) in dentistry. Methods: BDS students including
interns were asked to ll a questionnaire having 17 questions, structured into 2 sections: the rst part of the questionnaire was about
sociodemographic characteristics. In the second part, the respondents were presented with 15 statements and asked to dene their level of
agreement by choosing one of the following values: disagree, do not know, and agree. The questionnaires were evaluated to assess students'
attitudes and perceptions regarding the use of articial intelligence in dentistry based on their sex and year of study using Chi-square test. The level
of statistical signicance was determined at p<0.05. Results: Out of the 224 respondents, 21% were males and 79% were females. Maximum
participants were BDS second year students (28%). 84.1% participants agreed that AI can be used as a treatment planning tool in the diagnosis and
planning of dental treatment. Majority participants agreed that AI applications should be part of undergraduate and postgraduate dental education.
However, majority participants disagreed that AI may replace dentist and doctors in the future. Conclusion: The study reveals a generally positive
perception among dental students towards the integration of AI in dentistry. However, there is a consensus that while AI can signicantly assist in
routine and analytical tasks, it cannot replace the judgment and interpersonal skills of dentists.
THE ROLE OF CEREBROSPINAL FLUID DYNAMICS IN ARACHNOID GRANULATIONS AND BRAIN HERNIATION: CLINICAL SIGNIFICANCE AND IMPLICATIONS
Authors: Pratapbhai Gohil Abhishek , Rahul B N , Rao Baru Rama Krishna , Teja Nerella Krishna
Published: September 2024

Background: Arachnoid granulations (AGs) are small projections into the brain's venous sinuses, crucial for cerebrospinal uid (CSF) absorption.
Brain herniation into arachnoid granulations (BHAGs) is associated with elevated intracranial pressure, particularly idiopathic intracranial
hypertension (IIH). This study investigates the prevalence and clinical signicance of AGs and BHAGs purpose: in patients with headaches,
vertigo, and pulsatile tinnitus. A retrospective study of 200 patients undergoing MRI from January 2 Methods: 022 to January 2023 assessed T2-
weighted imaging (T2WI). Inclusion criteria focused on patients over 18 with unexplained neurological symptoms. AGs were present in Results:
13.6% of patients, with BHAGs observed in 7%. Among BHAG patients, 57% showed features of IIH. Temporal BHAGs were most common,
constituting 64.3% of cases. AGs are common ndings, while BHAGs signicantly correlate with IIH. Th Conclusion: eir presence warrants
further evaluation for elevated intracranial pressure, emphasizing their importance in clinical practice.
A RARE CASE OF TRANSVERSE VAGINAL SEPTUM PRESENTING WITH PRIMARY AMENORRHEA
Authors: Devi. S. S Monisha , M Pavithra.
Published: September 2024

Transverse Vaginal Septum is a rare congenital anomaly of the female genital tract. It may be obstructive or non-obstructive, and patients with
obstructive features are diagnosed earlier. Common presentations include lower abdominal pain, urinary retention, and constipation in the
background of primary amenorrhoea. Herein, we present a case of a 13-year-old adolescent girl who presented with acute lower abdominal pain
and urinary retention. A mid-vaginal transverse septum was observed on vaginal examination. On sonography, signicant hematocolpos were
visualised and a septate uterus was noted. The patient underwent a complete excision of the transverse septum. The postoperative period was
uneventful, and the patient began to have normal menstruation. Early diagnosis, adequate surgical management, and proper follow-up are key to
successful management of transverse vaginal septae. Further research is necessary to better classify and standardise treatment protocols due to the
paucity of reported cases.
NAVIGATING ONLINE HEALTH: A CROSS-SECTIONAL STUDY OF SELFDIAGNOSIS AND SELF MEDICATION AMONG STUDENTS IN BENGALURU
Authors: Rehanuddin Shaikh Mohammad , Gangadhar Aakash M , Kempanna Kavya , Yadav Vidit , Nandeesha Sanath Savithri
Published: September 2024

Introduction: Self-diagnosis, which is dened as diagnosing one's health issues without professional medical guidance, has become increasingly
prevalent worldwide. This study aims to estimate the proportion of students in Bengaluru who use the internet for self-diagnosis and self-treatment,
evaluate their reasons for doing so, and assess their perception of the accuracy and satisfaction with online health information. Materials and
Methods: A cross-sectional survey was conducted among students over 18 years old with internet prociency in Bengaluru, Karnataka. The study
excluded individuals with a medical background. The estimated sample size was 227, based on an 82% proportion of smartphone users. Data
collection involved a self-administered questionnaire distributed via Google Forms to participants who met the inclusion criteria. The
questionnaire included sociodemographic details, frequency of internet use for self-diagnosis, reasons for using the internet, perceptions of
accuracy and satisfaction, conditions sought for self-diagnosis and self-medication practices. Ethical approval and online consent were obtained,
and the data were analyzed using SPSS version 26. The study surveyed 229 students, with a mean age o Results: f 22.8 years; 53.7% were male, and
43.3% were female. About 48% of participants used the Internet for self-diagnosis. The primary reasons included personal convenience (26%),
laziness (25%), and long waiting times (17%). Conditions frequently researched online were hair fall (47%), headaches (33%), and colds (28%).
While 79% of participants were satised with their self-diagnosis, only 27% self-medicated. Some of the participants (16%) argue with doctors
based on their online diagnoses, and 68% recommended internet self-diagnosis to others. However, only 2% believed the internet was 100%
accurate for self-diagnosis, with the majority rating accuracy at 50% or less. The study highlights Conclusion: the high prevalence of internet use
for self-diagnosis among students in Bengaluru, driven by factors like convenience and cost. Despite the satisfaction reported by users, the
accuracy of online health information remains questionable. This underscores the need for better public education on the risks of unsupervised drug
use and the importance of professional medical advice. Health professionals should guide and caution patients in safely navigating online health
information to mitigate potential health risks associated with self-diagnosis and self-medication.
REDUNDANT CAUDA EQUINA NERVE ROOTS: THEIR IMPLICATIONS IN LUMBAR SPINAL STENOSIS
Authors: J Satwik , A N Prakruthi , A Patil Navin
Published: September 2024

Aims: This study examines the association between lumbar spinal stenosis and redundant nerve roots of the cauda equina (RNRCE), focusing on
their prevalence and clinical implications. Methods: MRI data from 37 patients with lumbar stenosis and 21 without were retrospectively
analyzed. Patients were grouped based on dural sac cross-sectional area (CSA). Chi-square tests and odds ratio calculations assessed the
association between stenosis and RNRCE. Results: RNRCE was present in 60% of stenosis patients and 10% of controls. Stenosis patients were
15.6 times more likely to exhibit RNRCE (p < 0.01). Conclusion: Lumbar stenosis, indicated by a dural sac CSA of less than 50mm² on MRI,
signicantly increases the risk of RNRCE. These ndings underscore the importance of recognizing RNRCE in lumbar spine evaluations to
enhance diagnostic accuracy and patient management. Further research is needed to explore the full clinical implications of redundant nerve roots
of the cauda equina.
Assessment of the current state of pharmaceutical development of anti-staphylococcal prophylactic drugs
Authors: Builova Irina A. , Savkina Maria V. , Sayapina Lidiya V. , Krivykh Maxim A. , Obukhov Yury I.
Published: September 2024

Infection caused by Staphylococcus aureus is the most common infection leading to the development of serious complications in humans. S. aureus is among the highly lethal bacteremia-associated pathogens with a mortality rate of approximately 18% in industrial countries; in developing countries, the rate is even higher, up to 27%.
One of the most striking and challenging aspects of clinical manifestations caused by S. aureus is the ability of the bacterium to develop resistance to antibiotics. The development of alternative treatment options for staphylococcal infection is urgently needed. The use of immunotherapy and immunoprophylaxis to activate the anti-infection immune response in patients should be considered as a promising direction.
Objective: to analyze the main trends in the development of vaccines aimed at the prevention of S. aureus infection and its virulence factors.
The present review discusses vaccine development in recent years aimed at preventing infection caused by S. aureus. Particular attention is paid to pathogenicity factors (such as capsule, surface proteins and enzymes) that may be useful for the development of new candidate vaccines or immune therapeutics. In recent years, numerous clinical trials of candidate vaccines based on different antigens, taking into account particularly relevant S. aureus pathogenicity factors that influence morbidity, have not been successful due to their low efficacy or insufficiently substantiated safety (development of adverse events). One of the most important factors constraining vaccine development is the lack of successful translation of vaccine protective activity, which is observed in preclinical studies in experimental models but not confirmed in clinical trials.
Therefore, according to numerous researchers, the use of multiple antigens in vaccine formulations should be considered with the focus on different mechanisms of S. aureus pathogenicity and the use of adjuvants.
The molecular-genetic characteristics of uropathogenic Escherichia coli isolated from pregnant women with asymptomatic bacteriuria
Authors: Khusnutdinova Tatiana A. , Budilovskaya Olga V. , Krysanova Anna A. , Shalepo Kira V. , Sinyakova Anna A. , Savicheva Alevtina M. , Kogan Igor Yu.
Published: September 2024

Introduction. Uropathogenic Escherichia coli (UPEC) are the dominant bacterial pathogens of urinary tract infections (UTIs). UPEC belong to different phylogenetic groups and have many virulence factors, the study of which, in conjuction with the assessment of their relationship with clinical forms of UTI, is necessary for a better understanding of the pathogenesis of UTI and the development of new diagnostic algorithms.
Aim: determination of the molecular genetic characteristics of uropathogenic Escherichia coli isolated from pregnant women with asymptomatic bacteriuria.
Materials and methods. Clinical isolates of uropathogenic E. coli (n = 70) from pregnant women with asymptomatic bacteriuria were included in the study. The PCR method was used to determine the belonging to phylogenetic groups and detect 15 virulence markers — genes associated with adhesion (fimH, papC, sfa, afa, focG); toxin synthesis (cnf 1, hlyA, sat, vat, usp); siderophores (fyuA, iroN, iuc); capsular antigen (kpsMII). To assess the statistical significance of differences, Fisher's exact test was used. Differences were considered statistically significant at a confidence interval of 95% (p 0.05).
Results. Most of the UPEC isolates belonged to phylogroup B2 (51,4%) and were characterized by the detection of all UPEC-associated virulence factors included in this study; genes associated with adhesion (sfa, focG), invasins (ibeA), synthesis of toxins (hlyA, cnf1, vat, usp) and capsule (kpsMII), siderophores (fyuA, iroN, hlyA) were detected significantly more frequently (p 0.05). Two or more virulence determinants were detected in 93% of isolates.
Conclusion. The identification of key determinants of virulence and/or a combination of virulence genes can be a prognostic marker for predicting the course of UTI, especially in pregnant women, and will expand diagnostic capabilities taking into account the virulent properties of the uropathogen.
Evaluation of symbiotic relationships of oral microorganisms and their effect on the development of inflammatory changes of the oral mucosa in the complete absence of teeth
Authors: Shulyatnikova Oksana A. , Yakovlev Mikhail V. , Godovalov Anatoly P.
Published: September 2024

Introduction. By fixing on the exposed surfaces of complete removable dentures and oral soft tissues, bacteria form a biofilm, thereby increasing their overall virulence and resistance. The microorganisms that make up the biofilm are often in a symbiotic relationship, which allows them to increase their pathogenic potential and cause the development of denture stomatitis. Accordingly, when a particular strain is present in the oral cavity, the risks of symbiosis are significantly increased.
The aim of the study was to evaluate the effect of symbiotic relationships of oral bacteria on the development of inflammatory changes in the oral cavity in the absence of teeth.
Materials and methods. Two groups of patients belonging to the elderly age according to WHO systematization (60–74 years) with complete absence of teeth (K08.1) were formed, differing in the presence of clinical manifestations of inflammation (82 men and 49 women). Biological material sampled from the oral cavity of patients was studied using the culture method and RT-PCR. To quantify the interaction between members of the microbiocenosis, we used the Jaccard similarity coefficient.
Results. Coagulase-negative and coagulase-positive staphylococci, Neisseria, Candida spp., Enterobacterales and F. nucleatum were more frequently found in patients with complete absence of teeth. Expressed symbiotic relations between microorganisms of the Enterobacterales order, Lactobacillus, Neisseria and Corynebacterium genera, as well as S. salivarius, C. albicans, F. nucleatum were established. The nature of these relations depended on the presence of inflammatory changes in the oral mucosa and, in turn, influenced the development of the latter. Thus, in the absence of inflammation, Corynebacterium, Lactobacillus and S. salivarius showed stable synergism. In case of inflammation, the association between these bacteria was accompanied by the introduction of F. nucleatum and displacement of S. salivarius.
Conclusion. Thus, conditionally pathogenic microorganisms, forming microbial associations with multidirectional symbiotic relations increase their virulence, which allows them to occupy free niches in the oral cavity and subsequently trigger the development of pathological process of inflammatory character of prosthetic bed tissues.
PEMANFAATAN LAHAN TANAMAN CABAI BAGI UMKM DALAM MENINGKATKAN PEREKONOMIAN DI AMBARAWANG DARAT, KABUPATEN KUTAI KARTANEGARA, KALIMANRAN TIMUR
Authors: Azizil Yudaruddin Yanzil , Ramadhani Ranita , Karlinda Sari Dika , Juwari Juwari , Della Ananda Lesmana Siti
Published: September 2024

Due to its high economic value, chili (Capsicum annum L.) horticultural commodities are in great demand. As the population and industry increase, the need for chili as a raw material also increases, as does the need for chili every year. In Jember Regency, red chili productivity is also low, only 87.68 quintals hectare-1. Several factors cause fluctuations in red chili production in the Kutai Kartanegara region, including unfavorable environments such as low soil fertility, high pest attacks, and excessive use of pesticides. As a result, agricultural development is needed to meet food needs and expand export opportunities to neighboring countries. Secondary data derived from land unit maps provide the parameters observed in this study. Setting the spacing, applying organic matter, agricultural lime, fertilizing phosphorus (P), as well as cutting and backfilling the soil with a mound or bench terrace system to reduce soil erosion are corrective steps to increase the land suitability class. Secondary data includes soil drainage, soil depth in cm, slope associated with erosion, elevation, waterlogging, and soil cation exchange capacity.
The Effect of Strategic Administrative Initiatives on Academic Performance in Kisii County’s Public Secondary Schools, Kenya
Authors: Omwando Oyaro Evans , Kennedy Getange , Enock Obuba
Published: September 2024

Strategic administrative initiatives in schools helps in identifying emerging trends and anticipate future challenges, allowing them to prepare and respond proactively so as to bring change in students’ academic performance. For three consecutive years (2016 -2018), Kisii County’s mean standard score in Kenya Certificate of Secondary Education declined resulting to an average mean standard score of 3.765 (D+) which was still below the National Mean Standard Score of 3.962. The purpose of this study was to determine the extent to which strategic administrative initiatives influence academic performance. Education Production Function theory was applied. The study employed a descriptive survey design. Target population of 353 principals and 4354 teachers were considered from 353 public secondary schools in Kisii County. Slovin’s formula with a margin error of 0.05 was used to sample 28 principals and 341 teachers as respondents. Stratified random sampling was used to get school categories. Instruments for this research included: questionnaire for teachers and interview schedule for principals. Validity of research instruments was ascertained by supervisors’ inputs from the School of Education Kisii University. Questionnaires were considered reliable since Cronbach’s Coefficient Alpha 0.998 obtained was higher than the critical Cronbach alpha of 0.7 on a scale of -1 to +1 by use of test re-test method. Data was analysed both qualitatively and quantitatively. Qualitative data on interview schedules were organized based on research objective and themes of study. Data was presented using percentages, means, frequency distribution tables and bar graphs for easier interpretation. This study’s findings were: The strategic administrative initiatives have a positive influence on academic performance. This study is significant as it indicates that county and sub-county secondary schools need to improve on the application of the strategic administrative initiatives in the academic activities/programs for them to do better academically. In conclusion, National and Extra- County secondary schools’ strategic administrative initiatives have a high positive influence on academic performance compared to county and sub-county secondary schools.
Smallholder Farmers' Demand for Rice Harvesting Technology: Analyzing Willingness to Pay Using One-and-One-Half Bounded Contingent Valuation Method in Northwestern Ethiopia
Authors: Yenewa Workineh
Published: September 2024

Background: This study was designed to measure farmers’ willingness to pay for mechanized rice harvesting technology rental service. Specifically, the study addresses how much they are willing to pay and what factors hinder farmers' WTP for mechanized rice harvesting technology by using a one and one-half bounded elicitation Contingent Valuation method and the Craggit econometric model. Methodology: Selecting representative samples for this study involved using a multi-stage sampling strategy. A total of 190 smallholder farmers were randomly selected to collect primary data. Results: The result revealed that nearly four-fifth of the sample respondents were willing to pay for mechanized rice harvesting technology rental service. Besides, smallholder farmers' willingness to pay for mechanized rice harvesting technology rental service varies between 200 and 1900 birr, with an average value of 890.46 birr per timad. Conclusion: Moreover, the model result indicated that sex of the respondent, family size, access to extension service, access to training, participation on field day, and livestock ownership had positive and statistically significant effect on mechanized rice harvesting technology rental service. Thus, in order to offer smallholder farmers with more access to technology at a reasonable rental cost, policymakers, development workers, researchers, and rental service providers should collaborate.
Knowledge of Hepatitis-B Management and its Prevention among the Senior Staff Nurses Working at Bangabandhu Sheikh Mujib Medical University (BSMMU)
Authors: Begum Delowara , Rozario Mabel D , Nasrin Most. , Akter Halima , Gharami Tumpa , Dina Meherunnesa
Published: September 2024

Background: Hepatitis B, caused by the Hepatitis B virus (HBV), presents a significant global health challenge, especially in regions like Bangladesh where its prevalence is intermediate. The virus is transmitted through percutaneous or mucosal exposure to infectious blood or bodily fluids, posing a substantial risk to healthcare workers. Hepatitis B can lead to severe liver diseases if untreated. In Bangladesh, the burden of Hepatitis B is high, necessitating urgent intervention, particularly among healthcare professionals such as senior staff nurses who are on the frontline of managing and preventing the disease. Methods: This cross-sectional study assessed the knowledge levels of 210 senior staff nurses at Bangabandhu Sheikh Mujib Medical University (BSMMU) regarding Hepatitis B management and prevention. A structured questionnaire, translated into Bengali, was used for data collection through structured interviews. Convenience sampling was employed, and data were analyzed using SPSS (Version 24.0). Descriptive statistics and t-tests/ANOVA were used to explore the relationship between socio-demographic characteristics and nurses' knowledge about Hepatitis B. Ethical clearance was obtained from the Institutional Review Board (IRB) of BSMMU. Results: The majority of respondents were female (70%), aged below 30 years (59.5%), and had basic nursing education (89.5%). Most had 1-10 years of work experience (89%) and earned less than 35,000 BDT monthly (78.1%). Regarding vaccination, 64.3% had completed it, 26.7% were partially vaccinated, and 9% were unvaccinated. Occupational exposure to blood or body fluids was reported by 73.3% of nurses. Knowledge about Hepatitis B infection, transmission, and prevention was generally high, with 85.44%, 89.14%, and 85.11% of nurses demonstrating good knowledge in these areas, respectively. Marital status and vaccination status were significantly associated with higher knowledge levels (p < 0.05). Conclusion: Senior staff nurses at BSMMU exhibit substantial knowledge about Hepatitis B infection, transmission, and prevention. However, misconceptions persist regarding non-transmission routes and some preventive measures. Married nurses and those with complete vaccination status demonstrated higher knowledge levels. These findings highlight the need for targeted educational interventions to address knowledge gaps and reinforce preventive practices among nurses. This study underscores the importance of continuous education and vaccination programs to enhance the effectiveness of Hepatitis B management and prevention efforts in healthcare settings.
A Method for Studying the Size and Position of the Apical Bases of the Jaws Using Computed Tomography of the Jaws
Authors: Slabkovskaya A.B. , Sevan S.M. , Sevan M.N. , Persin L.S.
Published: September 2024

The study of the apical bases has been relevant in orthodontics for many decades; its study was carried out both on jaw models and on lateral cephalograms. Dentistry today is impossible without three-dimensional studies, which allows you to study an object from any angle and visualize the smallest changes in the anatomical structures of the area under study. The use of cone beam computed tomography to study the apical bases of the jaws makes it possible to study the configuration, size, and position of both the bases themselves and the structures that form them. The parameters we proposed allow us to study the width, length and angle of inclination of the apical base on single CBCT sections. Clinical use of the proposed analysis will contribute to more complete and accurate orthodontic treatment planning.
Renal Carcinoma Associated with Xp11.2 Translocations and TFE3 Fusions, Confirmed by Flourescence in Situ Hybridization
Authors: Kader Dr Nazneen Abdul , Supriya Dr. N. K.
Published: September 2024

Renal carcinoma associated with Xp11.2 translocations and TFE3 fusions (Xp 11.2 RCC) form a new and little known entity of the WHO classification. It accounts for at least one-third of pediatric RCCs and 15% of RCCs in patients <45 years of age. Renal carcinoma associated with Xp11.2 translocations and TFE3 fusions (Xp 11.2 RCC) is a rare pediatric renal carcinoma diagnosed by fluorescence in situ hybridization (FISH). We report a case of Xp 11.2 RCC in a 13 year old girl, presented with hematuria. Mass was detected on CECT. She underwent nephrectomy and histopathological examination confirmed renal cell carcinoma. Type was confirmed by FISH. Renal cell carcinoma in pediatric age with characteristic morphology need to be subcategorized using ancillary methods. The most sensitive and specific immunohistochemical markers for these neoplasms are TFE3 protein and cathepsin-K3. Complete surgical removal of the tumour mass including the kidney is the preferred therapy in patients with lower stage ...........
Situação epidemiológica das mulheres vítimas de violência doméstica em Anápolis - Goiás: uma análise retrospectiva
Authors: Mariana Vieira de Andrade  , Beatriz Queiroz Labre Maria , Silva Migliavacca Laura , Vilela Rodovalho Isadora , Gomes e Silva Sarah , Garcia Nascimento Mirlene , Silva Constanza Thaise Xavier
Published: September 2024

Objetivo: descrever o perfil epidemiológico das mulheres vítimas de violência doméstica em Anápolis-GO, de 2017-2021. Métodos: trata-se de estudo descritivo, com dados de fichas de notificação de vítimas de violência doméstica cadastradas no Departamento de Vigilância Epidemiológica. Resultados: foram notificados 669 casos no período; entre a faixa etária de 18-40 anos (68,9%), pardas (69,8%), casadas/em união consensual (39,2%), ensino fundamental incompleto/completo (35,9%) e não gestantes (82,5%). O principal meio de agressão foi a força corporal (68,9%), e seu principal agressor foi do sexo masculino (79,3%); no qual a vítima mantinha uma relação conjugal como agressor (56,1%). Foi possível observar a recorrência das agressões nas diferentes faixa etária do estudo (recorrência presente: 47,2% das agressões; p=0,015). Nota-se também que os anos de 2020 e 2021 tiveram um menor número de casos, mostrando a influência da pandemia da COVID-19 no número de notificações. Conclusão: entre os casos notificados, verificou-se a predominância em mulheres jovens, pardas e que sofreram violência física, e perpetrada por parceiros íntimos, sendo recorrente a agressão.