bluuebunny/crossref_metadata_2025 huggingface dataset:
Подростковая преступность и ее профилактика при изучении курса ОБЖ в школе
Authors: Пимкин М.Ю , Федулова Я.А.
Published: June 2023

Статья посвящена такой актуальной проблеме как подростковая преступность. Рассмотрены основные характеристики данного явления, охарактеризованы направления профилактической работы. Показана роль школы как субъекта профилактики подростковой преступности. Раскрыт потенциал и направления работы по использованию школьного курса ОБЖ в профилактической работе по минимизации подростковой преступности.
СОЦІАЛЬНА ВІДПОВІДАЛЬНІСТЬ ЯК ІНСТРУМЕНТ ЗАБЕЗПЕЧЕННЯ СТАЛОГО РОЗВИТКУ ПІДПРИЄМСТВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ В УМОВАХ СОЦІАЛЬНОЕКОНОМІЧНОЇ КРИЗИ
Authors: Овчиннікова В. О. , Корінь М. В. , Обруч Г. В. , Чорнобровка І. В.
Published: June 2023

На основі ґрунтовного аналізу сучасного стану підприємств залізничного транспорту виявлено стале скорочення обсягових показників їх роботи і зниження частки залізничної компанії на ринку транспортно-логістичних послуг. Встановлено, що наростання проблем зношеності і технічної непридатності залізничної інфраструктури та рухомого складу призвело до скорочення провізної і пропускної спроможності підприємств залізничного транспорту та зниження якості залізничних перевезень. Доведено доцільність застосування інструментів забезпечення сталого розвитку підприємств, які довели свою ефективність в умовах системної кризи. Виявлено, що одним із найефективніших наразі антикризових інструментів забезпечення сталого розвитку підприємств є соціальна відповідальність. Досліджено особливості впровадження компаніями практики соціально відповідального господарювання. В умовах інтернаціоналізації та глобалізації бізнесу доведено доцільність впровадження принципів корпоративної соціальної відповідальності в діяльність національної залізничної компанії. Розроблено модель впровадження соціальної відповідальності в АТ «Укрзалізниця», що включає функціональний, забезпечуючий, інструментальний та результативний блоки реалізації цілей соціально відповідального господарювання підприємствами галузі.
Keeping the line in transition years: Comparison of preschoolers and nine graders
Authors: Havigerová Jana Marie , Loudová Irena , Košek-Bartošová Iva , Kocourková Karolína , Podubecká Dominika
Published: June 2023

The study deals with the graphomotor difficulties of children at the beginning and the end of primary school. The aim is to describe and analyze the occurrence of two manifestations of graphomotor problems: tremor and line continuity. The results of the redrawing of seven graphics were compared. Fifty-one (51) preschoolers and 22 nine graders participated in the research. The tremor was detected at 1/5 to 4/5 of preschoolers and at 1/5 to 3/5 of ninth graders; the prevalence of the tremor decreases with age. Significant differences were found in the number of interruptions in most tasks. Contrary to expectations, more interruptions were found among 9th graders. The result is interpreted based on declining experience with writing and drawing images larger than interlinear differences, experience interference such as writing through discontinuous cursive handwriting, favored by the majority of adolescents, and intervening personality characteristics such as perfectionism, and laziness.
Keywords: Adolescents; graphomotor skills; interruptions; preschool children; tremor
STRATEGI BRANDING DALAM MENGIMPLEMENTASIKAN PESANTREN PRENEUR
Authors: Masruroh Nikmatul , Zahirah Farah
Published: June 2023

Pesantren preuner hadir di tengah-tengah keadaan pengangguran muda Indonesia yang semakin meningkat.Hadirnya konsep ini, membuka ruang bagi pemuda-pemuda untuk ikut andil dalam kegiatan ekonomi gunamemberikan pendapatan negara.Pesantren sebagai lembaga pendidikan yang selama ini dipahami sebagai garda terdepan dalam upaya tafaqquh fiddin, akhir-akhir ini ikut hadir sebagai pencetus ide pemerkuat ekonomi umat dengan berbagai macam jenis usaha yang dimiliki. Pesantren Salafy Sidogiri Jawa Timur, selama ini menjadi ikon pesantren salaf, terbukti tidakmemiliki pendidikan formal di dalamnya, namun mampu melahirkan berbagai jenis usaha, guna menghidupkan perekonomian. Pola usaha yang dilakukan dengan memberdayakan santri dan alumni-alumni yang dimiliki. Agar pasca dari Pesantren tidak terjadi pengangguran.Selain itu keterampilan berwirausaha sudah dilatih mulai santri berada dalam Pesantren sembari tidak meninggalkan ilmu agama sebagai pengajaran pokok dari pesantren. Dari fenomena yang bertolak belakang tersebut, tulisan ini bertujuan mengungkaplatarbelakang Pondok Pesantren Sidogiri menggarap sektor preneur, di saat kebanyakan pesantren lain belum menggarapnya dan masih konsisten dengan keâ€™salafiâ€™ annya. Hal yang tidak kalah menarik tujuan penelitian ini untukmenguraimodel usaha dapat diambil pelajaran dan diadopsi sebagai strategi preneur pesantren lain, yaitu: mengenai kiat sukses usaha Pondok Pesantren Sidogiri dalam membangun kekuatan bisnisnya hingga seperti sekarang.
Creencias sobre el aprendizaje del inglés de estudiantes normalistas del estado de Chihuahua
Authors: Arán Ana , Ríos Cepeda Vera Lucía
Published: June 2023

Las creencias sobre el aprendizaje de un idioma influyen en las expectativas, opiniones y motivaciones de los estudiantes, facilitando o dificultando el proceso de adquisición de una lengua. Se presenta una investigación que describe y analiza las creencias sobre el aprendizaje del inglés de 261 estudiantes que cursan el sexto semestre la licenciatura en educación primaria o la licenciatura en educación preescolar, pertenecientes a tres escuelas normales del estado de Chihuahua, en México. El estudio se enmarca en el enfoque cuantitativo, y utiliza un diseño no experimental con alcance longitudinal de aproximación, a través del método de la encuesta y la aplicación del instrumento BALLI (Inventario de Creencias sobre el Aprendizaje de la Lengua) creado por Horwitz (1987). Los resultados muestran que el alumnado valora la práctica y repetición para adquirir la lengua extranjera, les parece importante la gramática y el vocabulario de la misma, y le otorgan mayor peso a la exposición a la lengua extranjera que a los aspectos culturales.

Students’ beliefs about learning a language influence their expectations, opinions and motivation, thus facilitating or inhibiting the language acquisition process. The purpose of this research is to describe and analyze the beliefs about English learning of 261 students that are in the sixth semester of the bachelor’s degree in elementary education or preschool education, who attend one of the three normal schools of the state of Chihuahua, in Mexico. The information regarding students’ beliefs can be used by teachers in their class’methodology, teaching approach and curricular design of the second language. The study uses the quantitative approach and a non-experimental design with a longitudinal approximation study, by employing the survey method and the BALLI instrument (Beliefs about Language Learning Inventory) created by Horwitz(1987). The results show that students value practice and repetition in order to learn the second language. Also, they think that grammar and vocabulary are important, and give a greater weight to being exposed to the language rather than the cultural aspects of it.
Book Review: Shin Yi Chew and Lee Luan Ng (2021). Interpersonal Interactions and Language Learning: Face-to-Face vs. Computer-Mediated Communication. Palgrave Macmillan
Authors: Godev Concepción
Published: June 2023

The content of this book can be fully appreciated within the context of Malaysia, a country that is home to approximately thirty-four million people with multi-ethnic backgrounds. While the official language is Malay, a multitude of languages are spoken in Malaysia. The country aspires to educate professionally competent citizens in order to increase their opportunities for advancement and to enhance the country’s ability for international relations and international trade. Rashid et al. (2017) point out that educational reform initiatives in Malaysia have often focused on language policy that places the English language at the center of curricular changes as English is viewed as the tool that may make it possible for the country to keep pace with its economic objectives. Within this view, English teachers have become key players in the implementation of educational reforms.
The current state of blood pressure measurement and emerging technologies
Authors: Ringrose Jennifer S. , Padwal Raj
Published: June 2023

Office blood pressure measurement has been the primary means of diagnosing and treating hypertension for almost a century. Increasingly, guidelines recommend out-of-office measurements (ambulatory or home blood pressure measurement) to confirm the diagnosis of hypertension and to follow treated patients. Ambulatory blood pressure measurement includes nocturnal measurement and provides a 24-hour blood pressure profile, enabling calculation of overall blood pressure, daytime mean, and nocturnal mean. Home blood pressure monitoring is a method of blood pressure measurement that is convenient and accessible. Blood pressure telemonitoring is a complementary and emerging technology that enhances the effectiveness of out-of-office blood pressure measurement and has the potential to improve the health of end users through engagement, efficiency, and enhanced communication with the care team. Blood pressure measurements can be obtained remotely, effectively transmitted to their health care team via telemonitoring for interpretation, and then a care plan can be developed and implemented. However, care must be taken to ensure that these emerging technologies record and transmit accurate blood pressure information in a secure and reliable manner.
Structure, magnetism and low thermal expansion in Tb1-xErxCo2Mny intermetallic compounds
Authors: Sun Yanming , Cao Yili , Ren Yang , Lapidus Saul H. , Li Qiang , Deng Jinxia , Miao Jun , Lin Kun , Xing Xianran
Published: June 2023

Here, we obtained a series of controllable thermal expansion alloys Tb1-xErxCo2Mny (x = 0-0.5, y = 0-0.4) by incorporating double rare earth doping and introducing non-stoichiometric Mn content. By varying the amount of Er or Mn, a low thermal expansion (LTE) is achieved in Tb0.6Er0.4Co2Mn0.1 (TECM, α1 = 1.23 × 10-6 K-1, 125~236 K). The macroscopic linear expansion and magnetic properties reveal that anomalous thermal expansion is closely related to the magnetic phase transition. Synchrotron X-ray powder diffraction results show that TECM is a cubic phase (space group: Fd-3m) at high temperatures, and a structural transition to a rhombohedral phase (space group: R-3m) occurs as temperature decreases. The negative thermal expansion c-axis compensates for the normal positive thermal expansion of the basal plane, resulting in the volumetric LTE. This study provides a new metallic and magnetic ZTE material.
CURRENT TRENDS IN DESIGN OF ELECTRIC SUBSTATIONS
Authors: Drubetskaya Tanya , Biltsman K.
Published: June 2023

The issue of using modern equipment in the construction and modernization of electrical substations is discussed in the article.

The current state of electrical substation equipment is analyzed. It is shown that more than half of the equipment has exhausted its technical resource. The percentage of refusals due to aging has increased significantly.

Modern trends in design and new concepts of construction and installation of electrical substations are described. The complete-block technology of construction of electrical substations is considered.

The experience of substation reconstruction in Europe is presented. ODD, MTS and GIS technologies are compared.

The main suppliers of equipment for electrical substations in Ukraine are characterized.

Variants of the use of electric and gas equipment are described.

 Concepts of closed modular construction and "hybrid modules" are given.

Gradual changes to the traditional for the unified energy system of Ukraine scheme "two working bus systems with a bypass bus system" are presented, depending on the choice of switching devices.

New schematic solutions for substations on desolderings are provided (the RP scheme of the TP supply voltage on desolderings with a jumper on separate equipment; a typical RP scheme of the TP supply voltage on desolderings on integrated power equipment, the RP scheme of the TP supply voltage on desolderings with a jumper on enlarged cells on an integral power equipment). The advantages and disadvantages of the presented schemes are analyzed. On the basis of a complex analysis, conclusions are made about the advantages and disadvantages of the presented schemes and the criteria for choosing one or another scheme and the corresponding equipment are presented.
JUSTIFICATION AND DEVELOPMENT OF THE DESIGN PARAMETERS OF PARAFFIN AUTONOMOUS HEATING DEVICES (TRENCH CANDLES)
Authors: Derevyanko Denis , Zaichenko Stefan , Pobigaylo Vitaliy , Zaichenko Daria
Published: June 2023

The work presents the general concept of creating autonomous heating devices, taking into account the peculiarities of thermal processes that occur during the generation, accumulation and consumption of heat generated in the process of burning paraffin. The main regularities of thermal radiation of paraffin autonomous heating devices have been established, taking into account the peculiarities of the interaction of the constituent elements, which will allow establishing the mutual influence of various parts of the research object on its condition. The main goal of the conducted research was experimental research with the development of new designs of paraffin autonomous heating devices, taking into account the peculiarities of thermal processes that occur during the generation, accumulation and consumption of heat. For the first time, the combustion process of a paraffin heating device of different power was experimentally investigated under conditions that are as close as possible to natural and operational conditions. On the basis of experimental data, the specific indicators of combustion power, heat transfer and efficiency of a paraffin candle were determined. It was determined that an increase in the power of paraffin autonomous heating devices leads to a rapid decrease in the efficiency, which is explained by a decrease in the stoichiometric coefficient of the combustible mixture. Recommendations have been established to optimize the design of paraffin autonomous heating devices, which will allow to reduce the consumption of paraffin. A new design of a multifunctional paraffin autonomous heating device has been developed, which contains several functions: a heat source for the room; light; heat accumulator. It is proposed to use a thin-walled metal cylinder with corrugated walls filled with paraffin as a heat accumulator for paraffin autonomous heating devices.
EVALUATION CRITERIA OF INSTALLED TRANSFORMER POWER AT DISTRIBUTION SUBSTATIONS OF ELECTRICAL NETWORKS
Authors: Yandulskyi O. , Mossakovskyi V.
Published: June 2023

This work is devoted to approaches to determining and substantiating the optimal power value of transformers that installed at distribution substations. During the selection of the transformer under working the electrical load schedule of consumers of distribution substation in the power grid, it is necessary to ensure in full using of every unit of installed transformer capacity. For example, there are three transformers that belongs to the 10 kV, 35 kV and 110 kV voltage levels. It is shown the calculation of the optimal value of the transformer power and the selection of this power is performed, based on the nomenclature of transformers. It was carried out a technical and economic comparison of possible combinations in number and capacity of transformers to set the optimal power level.

Active energy losses, profit from the transporting of active energy and the total discounted costs function are the estimation of the installed transformer capacity. The transformers chosen for installation at the substation of the power grid are estimated for the ability to work at the highest ambient temperature level of +40°С, based on the temperature of the hot-spot point on the surface of the insulation of the windings.

This work ends by conclusion in comparison of the results of two approaches to estimating the lifetime and residual operation life - when the hot-spot point is in stationary and when it moves during electric load changes.
Plane-Parallel Advective Flow in a Horizontal Layer of Incompressible Permeable Fluid
Authors:   Perm State University, Shvarts K. G.
Published: June 2023

In this paper a new exact solution of the Navier – Stokes equations in the Boussinesq approximation describing advective flow in a horizontal liquid layer with free boundaries, where the vertical velocity component is a constant value, is obtained. The temperature is linear along the boundaries of the layer. Solutions of this kind are used to close three-dimensional equations averaged across the layer in the derivation of two-dimensional models of nonisothermal large-scale flows in a thin layer of liquid or incompressible gas. The properties of advective flow at different values of Reynolds number and Prandtl number are investigated.
PERSEPSI ANGGOTA AKHWAT LEMBAGA DAKWAH UNIVERSITAS ISLAM INDONESIA TERHADAP WANITA MUSLIMAH YANG MEMPERLIHATKAN AURATNYA KEPADA WANITA NON MUSLIM PERIODE 2021/2022
Authors: Firdaus Allail Meylda , Yolanda Yuke , Haningsih Sri
Published: June 2023

Aurat merupakan batasan minimal dari tubuh laki-laki maupun perempuan (dalam kitab anggota tubuh yang wajib ditutupi atau sesuatu yang tidak boleh diperlihatkan pada selain muhrim (Pulungan, 2018). Aurat wanita yang wajib untuk ditutupi ketika berhadapan dengan laki- laki yang bukan muhrimnya adalah seluruh tubuhnya, kecuali wajah dan kedua telapak tangan. Sebagian ulama ada yang menambahkan pendapat kedua telapak kaki juga tidak termasuk aurat (Oktariadi, 2016). Adapun batasan aurat sesama wanita mencakup bagian pusar sampai lutut. Namun, ada beragam pendapat ulama terkait batasan aurat wanita muslimah dengan wanita non muslim. Sebagian berpendapat bahwa batasan aurat wanita muslimah di hadapan wanita non muslim berbeda dengan di hadapan wanita muslimah. Sebagian yang lain berpendapat bahwa aurat wanita muslimah di hadapan wanita non muslim, sama halnya dengan di hadapan wanita muslimah. Perbedaan ini terjadi dikarenakan adanya multitafsir terhadap QS. An- Nur/ 24 ayat 31. Tujuan penelitian ini bertujuan untuk mengetahui persepsi anggota akhwat Lembaga Dakwah Universitas Islam Indonesia, dengan menggunakan metode penelitian kuantitatif deskriptif. Teknik pengumpulan data melalui kuiseoner dengan jumlah sampel yang diambil adalah 32 responden. Metode yang digunakan dalam penelitian ini adalah non-probability sampling dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa 62,50% menyatakan wanita muslimah tidak dapat memperlihatkan auratnya kepada wanita non muslim. Sedangkan 37,50% lainnya menyatakan bahwa wanita muslimah dapat memperlihatkan auratnya kepada wanita non muslim.
Kata Kunci: Aurat Wanita Muslimah, Batasan Aurat,  Persepsi
Simulation Of The Process Of Injection Of Liquid Sulfur Dioxide Into A Porous Reservoir Initially Saturated With Methane And Ice
Authors: Gimaltdinov Ilias , Stolpovskii Maksim
Published: June 2023

The paper presents the results of modeling the problem of injecting liquid sulfur dioxide into a porous reservoir initially saturated with methane and ice. The model presented in the paper assumes the formation of three different regions, namely, the near one, saturated with liquid SO2 and its hydrate; the far one, containing methane and ice, and the intermediate one, saturated with methane and water. The effects of various parameters of the porous medium and injected SO2 on the nature of the course of the hydrate formation process have been studied. It is shown that with a decrease in reservoir permeability or injection pressure, the length of the intermediate region decreases, which in the limiting case means the formation of SO2 hydrate in the mode without the formation of an extended region saturated with methane and water. It is shown that such a regime is also typical for the case of high initial injection pressures, as well as low values of the initial reservoir temperature and injection temperature.
Forecasting the Fuel Consumption and Price for Future Pandemic Outbreak: A case study in the USA under COVID-19
Authors: Sakib Ahmed Nazmus , Razzaghi Talayeh , Bhuiyan Md Monjur Hossain
Published: June 2023

The COVID-19 epidemic and the measures adopted to contain it have had a significant impact on energy patterns throughout the world. The pandemic and movement restrictions led to unpredictable fluctuations in power systems demand and the fuel price for a delayed period. Monkeypox, another viral disease, appeared during the post-COVID period. It is assumed that the outbreak of monkeypox is unlikely due to the implication of preventive measures experienced by COVID-19. At the same time, the probability of an epidemic cannot be blindly overlooked. This paper aims to examine and analyze historical data to look at how much petroleum fuel was used for generating power and how the price of petroleum fuel changed over seven years, from January 2016 to August 2022. This period covers the time before the COVID-19 pandemic, during the pandemic, and after the pandemic. Several time-series forecasting models, including all four benchmark methods (Mean, Naïve, Drift, and Snaïve), Seasonal and Trend decomposition using Loess (STL), Exponential Smoothing (ETS), and Autoregressive Integrated Moving Average (ARIMA) methods have been applied for both fuel consumption and price prediction. The best forecasting method for fuel price and consumption has been identified among these methods. The paper also utilizes the ARIMAX model by incorporating multiple exogenous variables, such as monthly mean temperature, mean fuel price, and mileage of vehicles traveling during a certain period of pandemic lock-down. It will assist in capturing the non-smooth and stochastic pattern of fuel consumption and price due to the pandemic by separating the seasonal influence and thus provide a prediction of the consumption pattern in the event of any future pandemic.
The Level of Qualitative Perception in Two Public General Hos-Pitals in North-West of Romania
Authors: Dulău Dorel , Daina Lucia Georgeta , Tudoran Cristina , Coțe Adrian , Rus Marius , Lascu Camelia Florentina , Tudoran Mariana , Silaghi Gheorghe , Kovacs Noemi , Caita Georgiana Albina , Dulău Bianca Ana , Voiţă-Mekereş Florica
Published: June 2023

The patient's satisfaction level concerning hospitalization has certain particularities, related to the geographical area, medical/non-medical assistance, the age, incomes, morbidity and mortality of the population. The objective of this study is to emphasize the degree of patients' satisfaction, depending on the specialty of the hospitalization department: surgical, medical, oncological, psychiatry, and to evidence the factors influencing the reliability and accuracy of patients' answers, such as: the patient's health condition upon admission, the duration of the admission, the level of physical pain and the emotional state. Patients and methods: The research was conducted between April and December 2021 on patients hospitalized in two public hospitals from the north-west of Romania, both of them being independent Legal Entities: the Municipal Clinical Hospital of Oradea (MCHO) and the County Clinical Emergency Hospital of Oradea (CCEHO). Results: The lowest score of PSS recorded in these two analyzed public hospitals from the north-western of Romania was appointed for the Pharmaceutical availability of patients medical treatment (2.24), attitude of the staff (2.56) and the quality of nursing care offered (2.58). Conclusions: The hospital management’s focus has been set to improve the communication skills among medical staff, to evidence their compassion, politeness, and to ensure the availability of essential drugs.
Mathematical Modeling and Computational Simulation Applied to the Study of Glycerol and/or Molasses Anaerobic Co-digestion Processes
Authors: Ferreira Carolina Machado , Akisue Rafael Akira , De Sousa Júnior Ruy
Published: June 2023

Abstract: An attractive application of crude glycerol is in the generation of biomethane by means of anaerobic co-digestion, involving the decomposition of the organic matter in two or more substrates by bacteria and archaea, in the absence of oxygen. Thus, the objective of this work was to evaluate the potential of neural networks and fuzzy logic to predict the production of biomethane from the anaerobic co-digestion of glycerol and/or sugarcane molasses. Firstly, a reactor model was implemented using Scilab, with Monod kinetics involving two substrates and an intermediate (M2SI model), to generate a database for subsequent fitting and evaluation of neural and fuzzy models. The neural network package of Matlab was used. Fuzzy modeling was applied using the Takagi-Sugeno approach available in the ANFIS package of Matlab. The biomethane production results simulated by M2SI were used in neural network modeling, firstly employing a “generic” network applicable to all 8 scenarios. A very good fit was obtained (R²>0.99). Excellent performance was also observed for specific artificial neural networks (one for each condition). The parameters of the M2SI model for the 8 different conditions were also mapped using a neural network, as a function of the organic material composition. A fit with R²>0.99 was obtained using 25 neurons. In the case of the fuzzy logic, RMSE of 18.88 mL of methane was obtained with 216 rules, which was a value lower than 0.5% of the order of magnitude of the accumulated methane. It could be concluded from the results that fuzzy logic and artificial neural networks offer excellent ability to predict methane production, as well as to parameterize the M2SI kinetic model (using neural networks).
Functionalized Metal Nanoparticles in Cancer Therapy
Authors: Villalobos-Gutiérrez Paola Trinidad , Muñoz-Carrillo José Luis , Sandoval-Salazar Cuauhtémoc , Viveros-Paredes Juan Manuel , Gutiérrez-Coronado Oscar
Published: June 2023

Currently, there are many studies on the application of nanotechnology in therapy. Metallic nanoparticles are promising nanomaterials in cancer therapy, however, functionalization of these nanoparticles with biomolecules has become relevant as their effect on cancer cells is con-siderably increased by photothermal and photodynamic therapy, drug nanocarriers, and speci-ficity by antibodies, resulting in new therapies that are more specific against different types of cancer. This review describes studies on the effect of functionalized palladium, gold, silver and platinum nanoparticles in the treatment of cancer.
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
Authors: Soko Nyarai Desiree , Muyambo Sarudzai , Dandara Michelle T.L. , Kampira Elizabeth , Blom Dirk , Jones Erika S.W , Rayner Brian , Shamley Delva , Sinxadi Phumla , Dandara Collet
Published: June 2023

Pharmacogenomics may improve patient care by guiding drug selection and dosing, however this requires prior knowledge of the pharmacogenomics of drugs commonly used in a specific setting. The aim of this study was to identify a preliminary set of pharmacogenetic variants important in Southern Africa. We describe co-morbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV, and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using literature, a list of pharmacogenes vital in disposition of the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred in 31.5% of the participants and statins were frequently prescribed cholesterol lowering drugs. HIV was reported in 20.3% of the study participants with lamivudine/stavudine/efavirenz being the most prescribed antiretroviral combination. Based on these data, pharmacogenes of immediate interest in Southern African populations include ABCB1, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, SLC22A1, SLCO1B1 and UGT1A1. Variants in these genes are a good starting point for pharmacogenomic translation programs in Southern Africa.
M1/M3 Muscarinic Acetylcholine Receptors Control Long-Term, but Not Short-Term Plasticity at the Mossy Fiber – CA3 Pyramidal Cell Synapse in Mouse Hippocampus
Authors: Zheng Fang , Wess Jürgen , Alzheimer Christian
Published: June 2023

Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1-M5) are still not fully understood. Here, we studied how M1 and M3 receptors affect plasticity at the mossy fiber (MF)-CA3 pyramidal cell syn-apse. In hippocampal slices from M1/M3 receptor double knockout (M1/M3-dKO) mice, the signature short-term plasticity of the MF-CA3 synapse was not significantly affected. However, the rather unique, NMDA receptor-independent and presynaptic form of long-term potentiation (LTP) of this synapse was much larger in M1/M3-deficient slices compared to wild type slices, in both field potential and whole-cell recordings. Consistent with its presynaptic origin, induction of MF-LTP strongly en-hanced the excitatory drive onto single CA3 pyramidal cells, with the effect being more pronounced in M1/M3-dKO cells. In an earlier study (Zheng et al., 2012), we found that deletion of M2 receptors in mice disinhibits MF-LTP in a similar fashion, suggesting that endogenous acetylcholine employs both M1/M3 and M2 receptors to constrain MF-LTP. Importantly, such synergism was not observed for MF long-term depression (LTD). Low-frequency stimulation, which reliably induced LTD of MF synapses in control slices, failed to do so in M1/M3-dKO slices and gave rise to LTP instead. In striking contrast, loss of M2 augmented LTD when compared to control slices. Taken together, our data demonstrate convergence of M1/M3 and M2 recep-tors on MF-LTP, but functional divergence on MF-LTD, the net effect being well-balanced bidirectional plasticity of the MF-CA3 pyramidal cell synapse.
Oxidative Stress and ROS Linking Diabetes and Cancer
Authors: Black Homer S.
Published: June 2023

Type 2 diabetes mellitus (T2DM) accounts for one-sixth of deaths, globally, whereas cancer is the second leading cause of death in the U.S. T2DM is a known risk factor for many cancers. This review examines the link of Reactive oxygen Species (ROS)-altered metabolic and signaling pathways in T2DM to cancer. These reprogrammed metabolic and signaling pathways are activated that contribute to diabetic complications, impact redox balance (Oxidative Stress), and have differential roles in early and late stages of cancer. If the respiratory chain is highly reduced (as under hyperglycemic conditions) or if reduced cofactors accumulate, ROS are greatly elevated. ROS may cause mutations in mitochondrial DNA (mtDNA) that result in further ROS elevation. Amplification of ROS results in activation of PKC, an overarching signaling pathway that activates MAPK with subsequent regulation of several factors that result in pathophysiological manifestations of T2DM and cancer. Upregulation of PKC leads to deregulation of NF-kß that regulates the PKB/P13/Akt pathway that orchestrates cell survival, growth, proliferation, and glucose metabolism manifested in cancer. It also affects Insulin Receptor Substrate (IRS-1), decreasing insulin stimulated glucose transport and glucose uptake, disrupting subsequent cell signaling pathways contributing to the development of T2DM. Dyslipidemia is a hallmark of T2DM and cancer. ROS-induced lipid peroxidation leads to systemic inflammation, producing inflammatory prostaglandins, cytokines and chemokines that result in tumor proliferation, rapid tumor growth, and modulation of immunity. The dual role of ROS in early and late stages of cancer make antioxidant therapy precarious and may be responsible for controversial results. A system that delivers an antioxidant directly to mitochondria may be useful in inhibiting formation of ROS early during the pre-diabetic stage whereas antioxidant therapy must be halted in later stages to retard metastasis.
Use of Doping Substances in Sport. Information and Availability on the Internet
Authors: García Juan F. , Seco-Calvo Jesús , Arribalzaga Soledad , Díez Raquel , López Cristina , Fernández-Martínez María Nélida , García Juan J. , Diez M. José , De la Puente Raul , Sierra Matilde , Sahagún Ana M.
Published: June 2023

Dietary supplements are commonly used among athletes. The Australian Institute of Sport (AIS) groups supplements into 4 categories, being group D considered by the World Anti-Doping Agency (WADA) as prohibited supplements. The online availability of four doping substances: oxandrolone, dehydroepiandrosterone (DHEA), androstenedione and Tribulus terrestris, purchased from Spain, Puerto Rico, Canada, USA, Ukraine and Russia was evaluated. The characteristics of the websites, the countries the webs sold to, the pharmaceutical forms offered and the recommendations for its use were analyzed by using a computer tool designed ad hoc. There were significant differences between countries in the number of webpages that sold the products (Chi-square test, p<0.05). Oxandrolone was available for purchase mainly in Spain (27.12%) and Ukraine (26.58%), coming from websites dedicated to sports (77.26%). For DHEA, most of the pages were located in Canada (23.34%) and Russia (21.44%). Tribulus terrestris was the compound with the highest number of web pages. In the case of androstenedione, none of the pages for its sale requested prescription. Products such as androstenedione or DHEA are claimed to enhance sports performance or for sports use without providing details. The results showed that a limited number of Internet sites request prescriptions. Most of the doping substances are purchased from the country where they are requested. Athletes should be encouraged to consult health professionals about which supplements are suitable for their type of training and sports objectives.
A SURVEY OF MEDICINAL PLANTS AROUND UPPER SONGKHLA LAKE, THAILAND
Authors: Neamsuvan Oratai , Sengnon Narumon , Seemaphrik Nittaya , Chouychoo Metinee , Rungrat Rojjana , Bunrasri Sujittra
Published: June 2023

The aim of this study was to explore medicinal plants from upper Songkhla lake, Songkhla and Phatthalung provinces. Semi-structured interviews were conducted with seven key informants to get information regarding to the local names, parts and utilization, method of preparation, route of administration and properties of plants. Voucher specimens were prepared, identified and deposited. In total, 95 species belonging to 82 genera in 46 families were found. Among them 26 groups of ailments could be classified, and most of herbal plants were used for antipyretic (24.30%). However, only 39 medicinal plants were related to biological activities previously reported. Therefore, it is interesting to focus on these activities of remaining plants to confirm folk utilization of local healers. This compilation of medicinal plants will promote their practical use and be the data evidence for further conservation of the plants.
A COMPARATIVE STUDY ON THE APHRODISIAC ACTIVITY OF FOOD PLANTS MONDIA WHITEI, CHENOPODIUM ALBUM, CUCURBITA PEPO AND SCLEROCARYA BIRREA EXTRACTS IN MALE WISTAR RATS.
Authors: Sewani-Rusike Constance Rufaro , Iputo Jehu E , Ndebia Eugene J , Gondwe Mavuto , Kamadyaapa David R
Published: June 2023

Background: Any substance that increases erectile function, sexual performance and enjoyment is considered an aphrodisiac. The was to compare the effects of food plants Mondia whitei, Chenopodium album, Cucurbita pepo and Sclerocarya birrea extracts 200mg/kg body weight on sexual behavior, sperm parameters and testosterone levels in adult male rats. These are food plants also aphrodisiacs in South Africa, Zimbabwe and other parts of Africa.

Materials and methods: Sexual behavior parameters assessed in this study included an arousal component (mount latency and intromission sexual potency (mount frequency and intromission frequency), erection (copulatory efficiency) and ejaculations. All treatments orally daily for 28 days. Sexual behavior parameters were quantified 2 hours after a single dose, at 14 days and at 28 days of treatment.

Results: The order of efficacy in stimulating sexual behavior in male rats was M. whitei >S. birrea > C. pepo ≥C. album. Although change in number of ejaculations and sperm count (P>0.05) for all treatment groups compared to controls, all treatments increased motility. M. whitei and C. pepo treatments resulted in increased (P
ETHNOMEDICINAL PLANTS USED AGAINST COMMON DIGESTIVE PROBLEMS
Authors: Adnan Muhammad , Bibi Roqaia , Azizullah Azizullah , Andaleeb Rani , Mussarat Sakina , Tariq Akash , Ullah Riaz , AbdElsalam Naser M. , Khan Abdul Latif , Begum Shaheen
Published: June 2023

Background: Ethnomedicinal knowledge is highly significant for persistence of human health care. Different studies shown that medicinal

plants are considered as curing agent for digestive disorders in Pakistan. The aim of present review is to explore this ethnomedicinal information

all over the Pakistan and to investigate the ecological status of these species in the country.

Methodology: Online litera
ASSESSMENT OF KNOWLEDGE AND ATTITUDES TOWARD COMPLEMENTARY AND ALTERNATIVE MEDICINE (CAM) AMONGST TURKISH MEDICAL FACULTY STUDENTS
Authors: YURTSEVEN Eray , Vehid Suphi , Bosat Merve , SÃ¼mer Esin Cetinkaya , Akdeniz SÄ±dÄ±ka ipek , CÄ±ÄŸ GÃ¼lnaz , Tahirbegolli Bernard
Published: June 2023

Background: Complementary and Alternative Medicine (CAM) therapies are becoming increasingly acceptable to the general public and are

increasingly used around the world. The international rise in focus on CAM and the increased incorporation of CAM into medical curricula,

make it important to gain insight into the knowledge and attitudes of medical students about CAM and its integration in the medical curriculum.

Materials and Methods: In this present study, we attempt to investigate the Cerrahpasa medical faculty students’ knowledge, attitude and

practices of the on CAM. The study used a primary cross-sectional data collection from students of Cerrahpasa Medical Faculty, Istanbul

University, in 2012-2013 academic years.

Results: Students knowledge of CAM between classes was also compared. There were also statistically significant differences about the

knowledge of those methods (acupuncture, acupressure, yoga, reiki, prayer, meditation massage, dietary, spa). Prayer was the most known

modality in all medical classes’ students (first year students: 254, sixth year students: 192). The students who participated in the study stated that

433 (%59.4) have some knowledge about the acupuncture (first year students: 229, sixth year students: 204). Acupressure was found to be at

least known methods for CAM (first year students: 313, sixth year students: 282).

Conclusion: Medical students in our faculty also had limited knowledge about CAM therapies. Medical students also have an understanding of

the importance of CAM education in the medical curriculum, specifically how it will positively influence professional attitude and stimulate the

doctor–patient relationship.
Constitutional Framework for Planning Acts as Legal Forms of Administration’s Activity in Environmental Protection (on the Example of Poland)
Authors: Majchrzak Bartosz
Published: June 2023

Planning acts constitute a very important instrument for conducting environmental protection policy in Poland. Despite the relative freedom of public authorities in shaping their provisions, these acts are adopted on the basis of explicit authorisations contained – in principle – in universally binding law, primarily in statutes. The aim of the article is to draw attention to the fact that a quite detailed normative framework for adopting environmental planning acts is also present at the level of the Constitution of the Republic of Poland. Determining its scope, however, requires defining the legal nature of the indicated acts, which is an issue that raises certain problems. They are visible especially in the context of the administrative law doctrine.
New Charges on Communal Waste in the Czech Republic
Authors: Radvan Michal
Published: June 2023

The aim of this contribution is to confirm or dispute the hypothesis that the new system of charges for municipal waste management in the Czech Republic is suitable for both taxpayers and municipalities. To achieve this aim, the article critically describes the old and new methods of communal waste charging, compares the two, and highlights their weaknesses and strengths. In addition, it summarizes the opportunities and threats of new options so that municipalities receive more valuable information when deciding whether to tax communal waste and what charge is most effective in their territories.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 10.06.2023 г. по 16.06.2023 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: June 2023

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 10.06.2023 г. по 16.06.2023 г.
ANALISIS COMMON-SIZE UNTUK MENGUKUR KINERJA KEUANGAN PERUSAHAAN PADA PT XL AXIATA TBK DAN PT SMARTFREN TELECOM TBK YANG TERDAFTAR DI BEI PERIODE 2018 - 2020
Authors: Ningsih Widia Ningsih Alfiany
Published: June 2023

The research that has been done can be shown to determine the company's financial performance by using the common-size statement analysis method at the companies PT XL Axiata, Tbk and PT Smartfren, Tbk. Those listed on the Indonesia Stock Exchange in the period 2018 to 2020 are seen from the balance sheet and income statement. This research is quantitative descriptive. In collecting the data using the documentation method and in analyzing the data with the common-size analysis. Based on the results of the common-size analysis seen from the balance sheet of PT XL Axiata, Tbk in allocating its funds for assets part of the debt of PT Smartfren Telecom, Tbk. in allocating the use of assets from own capital, therefore increasing the margin of safety for creditors and can strengthen the statement of financial position. Then the common-size is seen from the income statement at PT XL Axiata, Tbk and PT. Smartfren Telecom experienced a decline in its net profit during the 2018 â€“ 2020 period, therefore its financial performance was not good. However, in the 2020 period financial performance has increased in terms of net income, therefore the financial performance is getting better.
IMPLEMENTASI CAPITAL ADEQUACY RATIO DAN HUMAN RESOURCE SLACK DALAM MENGOPTIMALKAN PENERAPAN SUSTAINABLE FINANCE
Authors: Selly Selly Puspita Sari , Sunarmi  , Mulyono Andi
Published: June 2023

Abstract

The research objective of this study was used to empirically examine data related to the effect of Capital Adequacy Ratio (CAR) and Human Resource Slack (HRC) on the implementation of sustainable finance implemented from 10 sub-sector sample companies in Islamic banks listed on the IDX for the period 2017- 2020. The analysis used to measure the variables to be examined uses multiple linear regression analysis to test and determine the causal relationship between the independent variables on the implementation of sustainable finance. The results of the research itself show conditions where the Capital Adequacy Ratio has no effect on the implementation of sustainable finance. In addition, a positive effect of Human Resource Slack was also found on the implementation of sustainable finance

Keywords capital adequacy ratio; human resource slack; implementation of sustainable finance.
The Potential of Municipal Sukuk Issuance in Indonesia - A Review of Theoretical Research
Authors: Ulfah Indar Fauziah
Published: June 2023

The main objective of this study is to provide local authorities with municipal Sukuk as an alternative to financing local infrastructure and developing areas. This study reviews the previous literature examining contemporary municipal sukuk and Discussed issues related to restrictions on the issuance of municipal sukuk. The research shows that the barriers to municipal Sukuk issuance are: Regional Barriers, Credit risk, Political Risk, Credit Weakness among stakeholders, Lack of through understanding of Shariah and financing and implementation. It was an exploratory study and aimed to identify barriers to becoming municipal bonds. Blocks of municipal Sukuk are listed from all possible sources. The study proposes some practical ways to overcome the obstacles to the provision of municipal sukuk in order to promote more municipal sukuk in various regions of the country to support sustainable development through equitable infrastructure distribution.
Analysis of the fluvial stratigraphic response to the Paleocene–Eocene Thermal Maximum in the Bighorn Basin, U.S.A.
Authors: Owen Amanda , Hartley Adrian J. , Hoey Trevor B. , Ebinghaus Alena , Jolley David W. , Weissmann Gary S.
Published: June 2023

Geological deposits can reveal how environments of the past have responded to climate change, enabling important insights into how environments may respond to our current anthropogenically induced warming. The Paleocene–Eocene Thermal Maximum (PETM) occurred ca. 56 Ma and was a short-lived (approximately 200,000 years) global warming event (5–8°C rise). The PETM has been investigated at several terrestrial and marine localities across the globe. However, many studies are based on single successions, with very few sites being placed within a well-defined spatial and temporal context and with comparisons limited to deposits that lie immediately above and below the event. Due to the inherent variability of sedimentary systems, it is imperative that the appropriate context is provided to fully understand the impacts of climate change on landscapes and subsequent deposits. This study examines 28 locations, totaling over 4 km of recorded stratigraphy, within a newly defined quantified sedimentary basin context (Bighorn Basin, USA) to evaluate variability of fluvial response to the PETM. We show that channel-body and story thicknesses across the PETM are not statistically significantly different from deposits outside the climate event, implying that there is not a consistent sedimentary response to the climate event across the basin. Based on our large dataset we calculate that precipitation would have had to double for statistically significant changes in deposit thickness to be generated. We discuss how climatic signals may be lost due to the self-organization, spatial–temporal varied response and preservation potential in large fluvial systems. This study gives a new quantified perspective to climate events in the geologic record.