bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPMENT OF TRANSPORT INFRASTRUCTURE FROM THE POSITION OF THE OMNICHANNEL APPROACH ON THE EXAMPLE OF THE REPUBLIC OF SAKHA (YAKUTIA)
Authors: Барыкин С.Е. , Лавская К.К. , Бурова А.Ю.
Published: May 2023

Данная статья посвящена вопросу развития транспортной инфраструктуры Республики Саха (Якутия) с позиции омниканального подхода. Авторы опираются на особенности территории республики и предлагают на основе одновременного развития транспортной и информационно-коммуникационной инфраструктур рекомендации для повышения транспортной доступности и возможности создания цифровой экосистемы из объединения цифровых платформ участников транспортной деятельности.

This article is devoted to the development of the transport infrastructure of the Republic of Sakha (Yakutia) from the position of the omnichannel approach. The authors rely on the peculiarities of the territory of the republic and offer recommendations on the basis of the simultaneous development of transport and information and communication infrastructures to increase transport accessibility and the possibility of creating a digital ecosystem from combining digital platforms of participants in transport activities.
Differential Diagnosis of Trauma Spectrum Disorders and Clinical High Risk for Psychosis
Authors: Welikson Tamara , Guvenek-Cokol Perihan Esra
Published: May 2023

Early identification of symptoms and accurate diagnoses are necessary for referrals to intervention programs, diagnostic conceptualization, treatment planning, recovery, pharmacotherapy decision-making, improvement in prognosis, functional capacity, and possible prevention of the emergence of full diagnostic disorders. Different symptom profiles have been shown to have more efficacious treatment approaches than others; however, differential diagnoses can be complicated when psychosis-like symptoms first start to emerge. Thus, learning how to differentiate between clinical high risk for psychosis, borderline personality disorder, and posttraumatic stress disorder to determine if a singular diagnosis or multiple comorbid diagnoses are necessary to improve patient care and treatment outcomes.

[
Psychiatr Ann
. 2023;53(5):204–208.]
Obsessions and Delusions: The Clinical Overlap and Differential Diagnosis of Obsessive-Compulsive and Psychotic Disorders
Authors: Guvenek-Cokol Perihan Esra
Published: May 2023

Obsessive-compulsive symptoms (OCS) are commonly observed in the pre-illness, prodromal, first-episode, and chronic stages of schizophrenia. Similarly, patients with obsessive-compulsive disorder (OCD) can present with delusional levels of conviction that border on psychosis. Transitions between OCD and schizophrenia spectrum disorders are also common. The phenomenological overlap between obsessions and delusions can be challenging for accurate diagnosis and treatment planning. Clinicians may struggle to differ entiate obsessions from delusions in severe OCD and similarly may not know if the emerging obsessive symptoms in schizophrenia require specialized OCD treatment. This review summarizes the current literature on comorbid obsessive-compulsive and psychotic disorders, transitions between these two disorders, the impact on prognosis, and the clinical strategies in differential diagnosis as well as treatment planning.

[
Psychiatr Ann
. 2023;53(5):199–203.]
Keratometry Agreement Between Two Swept-Source OCT Devices in Healthy and Post-refractive Surgery Eyes
Authors: Martínez-Albert Noelia , Nieto-Fernández Juan Carlos , García-Marqués José Vicente
Published: May 2023

Purpose:

To evaluate the keratometry agreement between two swept-source devices for healthy and post-refractive surgery eyes and compare them.

Methods:

One hundred volunteers between 20 and 55 years of age were recruited for this study including both healthy and post-refractive surgery eyes. Three consecutive measurements of simulated keratometry (Sim K), posterior keratometry (PK), and total keratometry (TK) were obtained with the IOLMaster 700 and Anterion. The agreement was assessed through the Bland-Altman method. Limits of agreement (LoA) were calculated as mean difference ±1.96·SD and it represents the 95% of the differences between devices.

Results:

For both groups, Sim K measurements exhibited a mean difference close to 0 and within a range of ±0.30 and ±0.36 diopters (D) for the control and post-refractive surgery groups, respectively. Meanwhile, the IOLMaster 700 provided flatter PK values (0.30 D on average) for both groups. In general, the post-refractive surgery group exhibited slightly greater mean differences and wider 95% LoA than the control group for Sim K and PK. Steeper TK values were obtained by the IOLMaster in both groups (control = 0.50 D and post-refractive surgery = 0.75 D). TK differences between devices were significantly greater in the post-refractive surgery group (ranging from 0.38 to 1.14 D) compared to the control group (ranging from 0.15 to 0.85 D).

Conclusions:

The IOLMaster 700 and Anterion are not interchangeable for TK measurements and eyes that had corneal refractive surgery even decreased the agreement between devices. Differences between devices for Sim K and PK measurements should be clinically judged, particularly in eyes with previous corneal surgery.

[
J Refract Surg
. 2023;39(5):347–353.]
Refractive Changes After Implantation of Reversed Intraocular Lens in Cataract Surgery: A Mathematical Model
Authors: Yang Hongseok , Matinrad Hedieh , Goldbaum Michael H. , Bu Jennifer J. , Fukuoka Hideki , Afshari Natalie A.
Published: May 2023

Purpose:

To develop a mathematical model that can predict the amount of refractive change caused by implantation of an intraocular lens (IOL) in a reversed position during cataract surgery.

Methods:

A theoretical mathematical formula based on the Gullstrand eye model was constructed to estimate the refractive change of the eye after implantation of a reversed IOL. The refractive change caused by implantation of the IOL in a reversed position was calculated based on the exchange of the anterior curvature with the posterior curvature of the IOL, and the lengthening of the distance between the IOL and the retina. In case of a three-piece IOL with angulation, the amount of refractive change was calculated based on its angle and the total refractive power of the eye, which is dependent on the focal length of the eye.

Results:

Calculated refractive change for one-piece IOLs was less than 0.10 diopter (D). For three-piece IOLs, the calculated refractive change makes the eye on average 0.77 D more myopic and can increase with the total refractive power of the patient's eye. The mathematical model was applied to seven previously published cases of reverse IOL implantation.

Conclusions:

This calculation demonstrates that with an upside-down IOL, there is a small refractive change in the one-piece IOL, including a toric IOL without angulation, but there can be a large refractive change in the three-piece IOL with angulation, especially using a higher power IOL or with a shorter axial length.

[
J Refract Surg
. 2023;39(5):326–331.]
Refractive and Visual Outcomes of SMILE for Compound Myopic Astigmatism With the VISUMAX 800
Authors: Reinstein Dan Z. , Archer Timothy J. , Potter Joseph G. , Gupta Ruchi , Wiltfang Rainer
Published: May 2023

Purpose:

To report the first refractive and visual outcomes of small incision lenticule extraction (SMILE) using the VISUMAX 800 femtosecond laser (Carl Zeiss Meditec AG).

Methods:

This was a retrospective analysis of consecutive eyes treated by SMILE using the VISUMAX 800 femtosecond laser at London Vision Clinic, EuroEyes Group, London, United Kingdom. Inclusion criteria were patients aged younger than 45 years, a corrected distance visual acuity (CDVA) of 20/20 or better, and the 3-month postoperative timepoint data being available for analysis. Standard outcomes analysis and vector analysis by the Alpins method were performed.

Results:

During the study period, 128 eyes of 66 consecutive patients were treated. Three-month data were available for 118 eyes (92%), and 10 eyes (8%) were lost to follow-up. The mean attempted spherical equivalent refraction (SEQ) was −4.65 ± 1.91 diopters (D) (range: −1.90 to −10.05 D) and the mean cylinder was −0.98 ± 0.78 D (range: 0.00 to −4.00 D). The mean age was 30 ± 5 years (range: 20 to 43 years), with 54% women and 46% men. Postoperative SEQ was within ±0.50 D in 86% and ±1.00 D in 100% of eyes. Uncorrected distance visual acuity was 20/20 or better in 91% of eyes. One line of CDVA was lost in 8% of eyes, and no eyes lost two or more lines. There was a small but statistically significant increase in contrast sensitivity at 3, 6, 12, and 18 cpd.

Conclusions:

Early outcomes data for SMILE with the second generation VISUMAX 800 femtosecond laser demonstrated an effective and safe option equivalent to published first generation VisuMax outcomes for the treatment myopia and astigmatism.

[
J Refract Surg
. 2023;39(5):294–301.]
Toric Trifocal Intraocular Lens for Refractive Lens Exchange: A Multi-center, Multi-surgeon Large Cohort Study
Authors: Wallerstein Avi , Gauvin Mathieu , Trottier Pierre , Cohen Mark , Lloyd John , Racine Louis , Albert Darren , Ahmed Iqbal Ike K. , Mimouni Michael
Published: May 2023

Purpose:

To assess the outcomes of a novel toric trifocal intraocular lens (IOL) for refractive lens exchange (RLE) in a large series of eyes with corneal astigmatism.

Methods:

Consecutive eyes that underwent RLE with the PanOptix Toric IOL (Alcon Laboratories, Inc) were included. Outcomes measures included postoperative distance (UDVA), 60 cm intermediate (UIVA), and 40 cm near (UNVA) uncorrected visual acuity, manifest refraction, spherical and defocus equivalent, efficacy and safety indices, and vector analyses of refractive and toric IOL accuracy.

Results:

A total of 4,933 eyes had a median follow-up of 3 months. UDVA of 20/20 and 20/40 was obtained in 65% and 99% of eyes monocularly and 87% and 100% binocularly, respectively. UIVA at 60 cm of 20/25 and 20/40 was achieved in 70% and 99% of eyes monocularly and in 77% and 100% binocularly, respectively. UNVA at 40 cm of 20/25 and 20/40 was achieved in 85% and 96% of eyes monocularly and in 95% and 100% binocularly, respectively. A total of 67%, 89%, 97%, and 99% of eyes had a SEQ within 0.25, 0.50, 0.75, and 1.00 diopter (D) of intended target (
R
2
= 0.99). Postoperative refractive astigmatism of 0.50, 0.75, and 1.00 D or less was achieved in 86%, 95%, and 98% of eyes. The vector analysis correction index and index of success were 1.04 ± 0.35 and 0.41 ± 0.31 for toric IOL accuracy and 1.00 ± 0.46 and 0.36 ± 0.55 for refractive accuracy, respectively. The 3- and 12-month post-RLE excimer laser enhancement rates were 1.1% (95% CI: 0.8% to 1.4%) and 7.6% (95% CI: 6.9% to 8.3%), respectively.

Conclusions:

The PanOptix Toric IOL performed well for a wide range of axial lengths and corneal astigmatism in eyes that had RLE. Most patients achieved effective uncorrected binocular near, intermediate, and distance vision for daily functioning.

[
J Refract Surg
. 2023;39(5):302–310.]
Influence of the Reference Center on the Calculation of Corneal Higher Order Aberrations
Authors: Smadja David , Greenbaum Assaf , Shoshani Avi , Abulafia Adi , Zadok David , Lavy Itay
Published: May 2023

Purpose:

To evaluate the differences in corneal wavefront measurements in myopic and hyperopic eyes when calculated using three different reference centers and explore possible influencing factors for such differences.

Methods:

Corneal wavefront measurements were performed in myopic and hyperopic eyes using a GALILEI Placido Dual Scheimpflug Analyzer (Ziemer Ophthalmic Systems AG). Corneal higher order aberrations (HOAs), including total, vertical, and horizontal coma-like aberrations, spherical aberrations, and total corneal HOAs through a 6-mm pupil size, were calculated over three different reference center positions: pupil center, corneal vertex, and limbus to limbus. Values were then compared between the myopic and hyper-opic eyes, and correlations with kappa distance and spherical equivalent were tested.

Results:

A significant decrease in the level of total corneal HOAs (−0.04 ± 0.05 and −0.12 ± 0.09), total corneal coma (−0.07 ± 0.09 and −0.18 ± 0.12), and horizontal coma (−0.07 ± 0.11 and −0.22 ± 0.11) in myopic and hyperopic eyes, respectively, was found when recalculating from pupil center to corneal vertex centration, whereas a significant increase in the same aberrations was observed from pupil center or corneal vertex to limbus to limbus. Significant correlations were found between the kappa distance and changes in total corneal HOAs, total corneal coma, and horizontal coma from the pupil center to the corneal vertex in both groups.

Conclusions:

Corneal vertex centration generated the lowest level of corneal wavefront error in both groups. The differences in corneal aberrations between the reference centers for calculation were highly correlated with the kappa distance in hyperopic eyes.

[
J Refract Surg
. 2023;39(5):340–346.]
Ostrácodos del tránsito Cenomaniense-Turoniense en los Montes Ksour y Amour (Atlas Sahariano): sistemática e implicaciones paleobiogeográficas
Authors: Benadla Mustapha , Marok Abbas , Soulimane Choukri , Reolid Matías
Published: May 2023

El estudio de los ostrácodos de la transición Cenomaniense-Turoniense (Cretácico superior) en los Montes Ksour y Monte Amour (Atlas Sahariano, Argelia) ha permitido la identificación de asociaciones fósiles típicas de este periodo caracterizado por cambios ambientales a escala global. La asociacion de ostrácodos consiste en 15 especies y 7 géneros, y se encuentra dominada por la familia Cytherellidae (principalmente el género Cytherella), y en menor medida por las familias Paracyprididae (exclusivamente Paracypris) y Trachyleberididae (principalmente Cythereis). Las formas menos comunes corresponden a las familias Bairdiidae, Bythocypridae y Macrocyprididae. Las asociaciones de ostrácodos del Atlas Sahariano fueron comparadas con las asociaciones de cuencas vecinas pertenecientes a la provincia paleobiogeográfica del Norte de África y Oriente Medio (margen septentrional de Gondwana) con el fin de encontrar similitudes entre cuencas. Así, el resultado obtenido muestra una gran similitud entre la fauna de ostrácodos de las cuencas del Atlas Sahariano en Argelia y Túnez. Por otro lado, existe similaridad entre las asociaciones de las cuencas de Marruecos y Egipto, y de ambas a su vez con las cuencas de Oriente Medio (Jordán y Omán). Finalmente, la fauna de la Cuenca Libanesa aparece relativamente aislada. Estas similaridades entre distintas cuencas desde el punto de vista palaeobiogeográfico pueden evidenciar cierta comunicación entre las mismas o condiciones ambientales equivalentes durante el tránsito Cenomaniense-Turoniense.
Using Sentiment Analysis to Explore Student Feedback: A Lexical Approach
Authors: Faizi Rdouan
Published: May 2023

Given the increasing abundance of online courses over the last couple of years, new forms of student feedback, which are less frequently used by teachers, have been generated in massive amounts. Nonetheless, extracting and processing this student generated content manually is costly and time consuming. In this respect, our objective in this paper is to propose a lexical-based approach that can predict the underlying sentiments of each student review, thus, enabling teachers to assess to what extent are students satisfied with the online learning resources and teaching practices. To enhance the performance of the proposed approach, a new education sentiment lexicon was built and incorporated into the model. After its implementation on a dataset that was extracted from the Web, this sentiment analysis lexical approach has proven to correctly predict the sentiment polarities of the great majority (i.e. 86.45%) of student feedback.
Online Sharing Mechanism of Digital Teaching Resources Considering Knowledge Potential Difference
Authors: Peng Yina , Tan Zhigang
Published: May 2023

The rapid development of emerging technologies, such as the Internet, big data, and artificial intelligence, has provided the technical foundation and conditions for digital online education resources. Knowledge potential difference has been ignored in current studies on teaching resource sharing, which cannot effectively meet the specific learning needs of students with different cognitive levels, and reduces their participation. Therefore, this paper studied the online sharing mechanism of digital teaching resources considering knowledge potential difference. This paper conducted and analyzed an online sharing model of learning resources between teachers and students considering knowledge potential difference, and described in detail the assumptions and steps for constructing the model. Then this paper constructed an effectiveness evaluation index system for the online sharing mechanism of digital teaching resources considering knowledge potential difference, and elaborated the specific steps for evaluating the effectiveness of the mechanism based on extension evaluation method. Experiment results verified the effectiveness of the proposed modeling and evaluation method.
Classroom Teaching Decision-Making Optimization for Students’ Personalized Learning Needs
Authors: Li Liyang
Published: May 2023

Classroom teaching is the basic form of teaching in colleges and universities. Teachers need to constantly optimize classroom teaching decision-making to adapt to the ever-changing educational environment. In order to improve the quality of teaching, stimulate students' potential, and promote students' all-round development, it is necessary to fully consider the personalized needs of students in classroom teaching and provide more suitable teaching content and methods for them. To this end, this article takes the accounting major in higher vocational colleges as an example, and conducts a study on the optimization of classroom teaching decision-making for students' personalized learning needs. It introduces the psychological curve function based on expected performance and current performance to measure the satisfaction degree of students' personalized learning needs, and as an evaluation of whether students' personalized learning needs meet expectations, elaborates on the calculation method of expected performance and current performance of personalized learning. A multi-objective decision-making model for classroom teaching is constructed to achieve the three optimization objectives of maximizing the quality of classroom teaching, maximizing the attention of students' personalized learning needs, and maximizing students' dissatisfaction, and the solution method of the model is given. Experimental results verify the effectiveness of the proposed algorithm and the constructed model.
Combination of M-learning with Problem Based Learning: Teaching Activities for Mathematics Teachers
Authors: Zakaria Mohamad Ikram , Abdul Hanid Mohd Fadzil , Hassan Roslizam
Published: May 2023

This study was conducted to identify elements (teaching activities) that teachers can engage with involving a combination of M-learning methods with Problem-Based Learning methods (M-PBL). This study was conducted using the Nominal Group Technique (NGT) involving 11 experts with various fields of expertise such as mathematics education, educational technology, M-learning, pedagogy and the curriculum as well as primary school mathematics education teachers. The analysis of the findings was carried out using descriptive statistics (percentages) to determine the priority and ranking for each teaching activity. The findings show that overall, there are 30 relevant M-PBL teaching activities that can be carried out by teachers. The findings also show that teachers sharing the learning objectives that the pupils need to achieve using learning applications that are available on mobile devices (98%) ranked first while the teacher classifying the information obtained from each group according to priority through learning applications available on mobile devices (75%) ranked last. In conclusion, this study shows that both methods can be combined to form a new teaching method in the current 4.0 education era.
Myocardin immunohistochemistry index is associated with clinical prognosis in nasopharyngeal carcinoma: a clinical practice-based cohort study
Authors: Chen Fu , Zhang Zhe , Song Xin-Mao , Xiao Xue , Zhou Xiao-Ying , Wang Sheng-Zi
Published: May 2023

Purpose: Recent findings have implicated the role of myocardin re-expression in carcinogenesisHowever, the clinical functions of myocardin in nasopharyngeal carcinoma (NPC) is not known yet. The purpose for the cohort research was to investigate whether myocardin re-expression level may predict clinical prognosis in NPC patients.Methods: 148 NPC patients were recruited from September, 2005 to September, 2011 with median follow-up time of 4.5 years in a clinical practice setting. At study entry myocardin re-expression of these patients was determined using immunohistochemistry (IHC) and additional 20 normal nasopharyngeal tissues were included as control. Two-sample t-test was used to compare mean myocardin reexpression levels and Chi-square test was used for comparing tumour recurrence rate. Logistic regression analysis was used for tumour local control rate, and log-rank test, Kaplan-Meier estimates and Cox proportional hazard model for disease-free survival and overall survival.Results: Myocardin IHC index was significantly downregulated in NPC samples than in normalnasopharyngeal tissues (mean ± standard deviation, 61.2 ±31.5 vs. 109.9 ±73.6, P= 0.009). However, among NPC patients was observed a roughly V-shaped change of myocardin IHC index according to Tumour T-stage (P=0.067); meanwhile higher IHC level was associated with more tumour recurrence rate in NPC patients (High vs. Low: 21.6% vs. 8.1%; P=0.021). Logistic regression analysis equally showed high myocardin IHC level was an independent risk factor for local tumour control rate regardless of adjustments [High vs. Low: unadjusted Odds Ratio (OR) 0.320, 95% confidence interval (CI): 0.117 to 0.871; P=0.026]. Moreover, higher myocardin IHC level was associated with a marginal but not significant risk increase of disease-free survival [High vs. Low: adjusted Hazard Ratio (HR) 1.760, 95% CI: 0.981 to 3.158; log-rank: P=0.129]. A less obvious trend was observed with regard to overall survival [adjusted HR 1.409, 95% CI: 0.715 to 2.77; log-rank: P=0.745].Conclusion: The study results suggested that high myocardin IHC index level could be a potential clinically prognostic intermediate biomarker for tumour recurrence for NPC patients in routine practice. Large well-designed cohort studies involving IHC re-expression change over time is needed.
Suppressive effect of Hsa-miR-125a-5p on cervical cancer proliferation and invasion via regulation of Rab25- PI3K/AKT pathway
Authors: Lin Huanming , Chen Chunjing
Published: May 2023

Purpose: To study the suppressive effect of Hsa-miR-125a-5p on the proliferation and invasion of cervical cancer (CC) cells through the modulation of the Rab25-PI3K/AKT pathway.Methods: 66 pairs of CC and neighboring cell samples were harvested from patients who underwent surgical resection in the Oncology Department from August 2017 to December 2018. The expression levels of Hsa-miR-125a-5p in CC and neighboring cell samples were assessed by quantitative polymerase chain reaction (qPCR). The overexpression vector was transfected into CC cells (siHa cell line), and the proliferation, invasion, migration, and apoptosis of siHa cells were determined. The regulatory role of Hsa-miR-125a-5p in PI3K/AKT pathway was determined using Western blotting.Results: CC tissues, relative to the neighboring tissues, exhibited remarkably lower Hsa-miR-125a-5p levels (p < 0.05), and their upregulation significantly inhibited the growth, migration, and intrusion of siHa cells while repressing apoptosis (p < 0.05). Dual-luciferase reporter assay (DLRA) data indicate that luciferase activity decreased when Hsa-miR-125a-5p was bound to Rab25 (p < 0.05). The HsamiR-125a-5p mimics group had significantly lower PI3K/AKT levels, relative to the negative control mimics group (p < 0.05).Conclusion: Hsa-miR-125a-5p represses CC cell proliferation and invasion through the modulation of Rab25-PI3K/AKT pathway, thus suggesting that this pathway is a target for drug development
Effectiveness of Zhixiao Decoction in children with bronchial asthma, and its effect on serum levels of IL-13, IL-6, and IL-17
Authors: Luo Wenjun , Chen Ming , Wang Wenbin
Published: May 2023

Purpose: To probe into the efficiency of Zhixiao Decoction in treating children with bronchial asthma, and its effect on serum levels of interleukin (IL)-13, IL-6, and IL-17.Methods: 140 children with bronchial asthma who were treated in the Affiliated Hospital of Shandong University of traditional Chinese medicine from February 2018 to October 2020, were included as the study group, while 70 children at the same period of physical examination served as the control group. Using the random number table, the study group was equally subdivided into regular group given Asthma-relief Oral Liquid, and treatment group given Zhixiao Decoction. Serum levels of IL-13, IL-6, and IL-17, and effectiveness and safety of Zhixiao Decoction, were measured.Results: Zhixiao Decoction showed higher levels of IL-13, IL-6, and IL-17 and greater treatment effectiveness in patients compared with Asthma-relief Oral Liquid (p < 0.05). IL-13, IL-6, and IL-17 levels exhibited negative correlation with FEV1 and PEF. The treatment group had lower post-treatment traditional Chinese medicine syndrome scores, serum levels of IL-13, IL-6, IL-17; fractional exhaled nitric oxide, and eosinophil counts. The treatment group also demonstrated higher scores in asthma control test, mini-asthma-related quality of life, and better lung function than the regular group (p <0.05).Conclusion: Zhixiao Decoction mitigates clinical symptoms of bronchial asthma children, improves lung function and clinical efficacy, and down-regulates levels of inflammatory cytokines. Thus, this therapeutic approach has potentials in the management of pediatric asthma.
Therapeutic potential of a combination of recombinant human growth hormone (r-hGH) and vitamin D in children with idiopathic short stature
Authors: Mei Wenlong , Wu Yupei , Shang Hongyue
Published: May 2023

Purpose: To study the effectiveness and clinical significance of recombinant human growth hormone (rhGH) in combination with vitamin D in the treatment of idiopathic short-stature children.Methods: A total of 90 idiopathic short-stature children admitted at Children Health Care Center of Shiyan Maternal and Child Health Care Hospital, Shiyan between March 2017 and March 2020 were assigned to three groups: A, B and C, based on dose of r-hGH given. Group A received r-hGH at a dose of 0.26 mg/kg/week, while groups B and C received r-hGH at doses of 0.35 and 0.42mg/kg/week, respectively. All the patients were given vitamin D along with the r-hGH doses administered. Height, growth rate, bone age, height standard deviation score, fasting blood glucose, thyroid function and treatment effectiveness were determined and compared among the three groups before treatment, and one year after treatment.Results: Significantly higher height standard deviation score, growth rate, bone age, and height were observed in the three groups of patients after one year of treatment than before treatment, with group A < group B < group C (p < 0.05). Fasting blood glucose and thyroid function were not significantly different amongst the three groups after treatment (p < 0.05). Group C showed the highest treatment effectiveness, followed by group B, and then group A (p < 0.05).Conclusion: The use of a combination of r-hGH and vitamin D produces a favorable treatment effectiveness in idiopathic short-stature children. However, further clinical trials are required to validate this treatment strategy.
Efficacy and safety of a combination of shuangdan mingmu capsules and laser therapy for diabetic retinopathy, and its effect on blood glucose indices and quality of life of patients
Authors: Zhang Rui , Feng Boru
Published: May 2023

Purpose: To investigate the efficacy and safety of a combination of Shuangdan Mingmu capsules andlaser therapy in diabetic retinopathy (DR), as well as on blood glucose index and quality of life.Methods: One hundred and twenty DR patients admitted to Zhenba County Peoples Hospital, Shaanxi were assigned equally to 2 groups: A and B. Retinal laser photocoagulation was performed for group B patients, while Shuangdan Mingmu capsules were given to group A, in addition to laser treatment. Ophthalmic parameters, blood glucose indices, ultrasonic indices, platelet parameters, quality of life, and incidence of adverse drug reactions (ADR) were determined and compared between groups A andB.Results: Following treatment, group A had significantly better ophthalmic parameters, blood glucose indices and platelet parameters (p < 0.05); better ultrasonic indices and quality of life (p < 0.001), and lower ADRs (p < 0.05) than group B.Conclusion: The combination of Shuangdan Mingmu capsules and laser therapy effectively cures ocular lesions, controls blood glucose, and lowers ADR in DR patients. Therefore, the combined therapy should be further investigated for the management of diabetic retinopathy.
High miR-34a and miR-26b expressions inhibit prostate cancer cell OPCN-1 proliferation and enhances apoptosis
Authors: Lin Yingwei , Sun Tao , Sun Guoliang
Published: May 2023

Purpose: To investigate the effects of miR-34a and miR-26b on the targeted genes, LEF1 and EphA2, and proliferation and apoptosis of OPCN-1.Methods: Sixty specimens of cancer tissue (CT) and equivalent tissue adjacent to tumors (TAT) were collected from prostate cancer patients. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to determine the mRNA expression levels of miR-34a, miR-26b, LEF1, and EphA2 in the above tissues, while protein expression levels of LEF1 and EphA2 were evaluated by Western blot.Results: Compared with TAT, the expression levels of miR-26b and miR-34a in CT decreased significantly (p < 0.05), whereas the mRNA and protein expression levels of EphA2 and LEF1 in CT significantly increased (p < 0.05). TargetScanHuman7.2 assay data revealed that miR-26b targeted EphA2, while miR-34a targeted LEF1. MiR-26b MG showed decreased EphA2 mRNA and protein levels when compared with miR-26b-NC group after overexpression. The miR-34a MG exhibited decreased expression levels of LEF1 mRNA and protein compared with the miR-34a-NC group. Between 48 and 72 h, miR-26b MG grew more slowly than miR-26b-NC group; miR-34a MG also showed significantly slower growth than miR-34a-NC group. The miR-26b MG and miR-34a MG groups displayed higher apoptosis rate than miR-26b-NC and miR-34a-NC groups, respectively.Conclusion: High expressions of miR-34a and miR-26b targeted the inhibition of LEF1 and EphA2, respectively, indicating that they inhibit the proliferation, and also control the increased apoptosis rate of OPCN-1 cells. Hence, miR-34a and miR-26b are probable molecular targets for the development of new prostate cancer drugs.
Atorvastatin suppressed proliferation and facilitated apoptosis of A549 cells through mediating recruitment of Fas and CD59 in lipid raft
Authors: Lu Jiahuan , Qiang Huiping , Chu Tianqing
Published: May 2023

Purpose: Lipid raft facilitated progression of NSCLC and atorvastatin could break cholesterol. The purpose of this study was to determine the potential mechanism of atorvastatin through lipid raft mediation in NSCLC.Methods: A549 cells were first grouped as NC, methyl-β-cyclodextrin (MβCD, lipid raft inhibitor, 5mM and 10mM), atorvastatin (0, 5mM, 10mM and 15mM) and MβCD (10mM) with atorvastatin (15mM). Later 10mM MβCD treated A549 cells were divided into three groups: NC, 3BDO (mTOR agonist) (60μM) and 3BDO (60μM) with atorvastatin (15mM) group. Thereafter, FLOT-2, SLP-2 expressions were assessed with RT-qPCR，mTOR proteins were measured by western blot and cell viability by CCK-8 method. Meanwhile, apoptosis was analyzed by flow cytometry. Moreover, lipid raft isolation was performed for acquiring Fas and CD59 and concentrations were detected by ELISA.Results: MβCD treatment significantly inhibited FLOT-2 and SLP-2 RNA expressions and cell viability of A549 cells but up-regulated apoptosis. Besides that, Fas protein level was promoted and CD59 was suppressed. Atorvastatin also repressed FLOT-2 and SLP-2 RNA levels. Meanwhile, atorvastatin downregulated cell viability and accelerated apoptosis. Moreover, Fas was increased and CD59 was inhibited by atorvastatin and MβCD enhanced functions of atorvastatin. MβCD inhibited mTOR RNA expression in A549 cells was increased by 3BDO but atorvastatin restored 3BDO caused up-regulation of mTOR. Furthermore, up regulated cell viability of A549 by 3BDO was declined with atorvastatin and decreased apoptosis by 3BDO was reversed through atorvastatin. Fas suppressed by 3BDO and promotion of CD59 were also resumed by atorvastatin.Conclusion: Atorvastatin suppressed FLOT-2 and SLP-2 and mediated recruitments of Fas and CD59 with suppressing cell viability and facilitating apoptosis of A549 cells via mTOR signaling pathway.
Lugrandoside attenuates spinal cord injury by targeting peli1 and TLR4/NF-κB pathway to exert anti-inflammatory and anti-apoptotic effects
Authors: Sheng Wenbo , Jiang Haitao , Yuan Hantao , Li Sibo
Published: May 2023

Purpose: To investigate the curative effect and mechanism of lugrandoside (LG) on spinal cord injury (SCI).Methods: We probed the expression of Pellino1 (peli1) in microglia and spinal cord tissues withdifferent treatments of LG. Lipopolysaccharide (LPS) was used to activate the microglia. Furthermore, rats were used to establish SCI model, and LG, at low and high concentrations, was administered to injured animals to ascertain whether LG exerted a therapeutic effect on SCI.Results: LG inhibited the activation and recruitment of glial cells by acting as a negative regulator of glial inflammation, and this reverse the targeting of peli1 and TLR4/NF-κB pathway. Furthermore, the in vivo data showed that LG exerted a neuroprotective effect, following SCI, via anti-inflammatory and antiapoptotic effects. Furthermore, Peli1 and TLR4/NF-κB were suppressed by LG stimuli.Conclusion: These results suggest that LG protects neural tissue against neuroinflammation and apoptosis by suppressing TLR4/NF-κB pathway and negatively targeting peli1. The findings may provide new insights into the treatment of spinal cord injury.
M echanism of lncRNA FOXD3 AS1 targeting miR 338 3p in human lens epithelial cell injury in diabetic cataract
Authors: Du QingWei , Wang LiLun , Li Mei
Published: May 2023

Purpose: To explore the influence of lncRNA FOXD3-AS1 on high glucose (HG)-stimulated human lens epithelial cell injury in diabetic cataract. Methods: Lens epithelial cell HLEB3 were cultured in vitro and transfected with si-FOXD3-AS1, miR-338-3p mimic or miR-338-3p inhibitor, followed by HG (40 mmol/L) treatment. FOXD3-AS1, miR-338-3p, cleaved caspases3 and cleaved caspases9 expression were analyzed by RT-qPCR or western blot. SOD and CAT activities and MDA production in cells were determined using special kits. Cell apoptotic rate was quantified by flow cytometry. Regulatory relationship of FOXD3-AS1 and miR-338-3p was investigated by mechanism assay. Results: HG enhanced FOXD3-AS1 expression but repressed miR-338-3p (P<0.05) in HLEB3 cells. FoxD3-AS1 depletion or miR-338-3p introduction promoted SOD and CAT activities, decreased MDA content, apoptosis rate, and cleaved caspases3 and cleaved caspases9 protein production in HG-induced HLEB3 cells (P<0.05). FOXD3-AS1 could target and negatively regulate miR-338-3p. FOXD3-AS1-mediated influence on HG-induced HLEB3 cells was rescued by miR-338-3p inhibitors. Conclusion: FOXD3-AS1 silenced upregulated miR-338-3p expression to alleviate HG-induced oxidative stress and apoptosis of HLEB3 cells.
Identification of immune regulatory protein coding genes in the development of lung adenocarcinom a (LUAD)
Authors: Ge Wen , Tang Hua , Wang Jing , Xu Yichun , Ma Haitao
Published: May 2023

Purpose: To verify the differential expressed genes (DEGs) based on The Cancer Genome Atlas (TCGA) using RNA-seq data from eight LUAD patients Methods: TCGA database was used for extraction and analysis of RNA-seq profile in LUAD patients. Then RNA sequencing was performed using the tissue samples from eight LUAD patients for comparison. Weighted correlation network analysis (WGCNA) was applied to establish the co-expression modules and identify hub genes using RNA-seq data from the eight LUAD patients. Protein-protein interaction (PPI) analysis was used to reveal hub genes and GO analysis was performed for functional annotation including immune responses. Results: ALDH3A1, METTL7B, WFDC2 and CDH23 that had close correlation with the immune system were identified by TCGA and validated by RNA-seq from the eight LUAD patients. IL17REL was revealed as a potential oncogene in LUAD. Conclusion: This study highlighted potentially useful biomarkers associated with LUAD development and diagnosis.
Application of two dimensional speckle tracking imaging in the follow up of patients with coronary heart disease treated with metalol
Authors: Li Mengyuan , Zhou Chunwang , Li Li , Ma Yi , Zhao Biqiong
Published: May 2023

Purpose: To investigate the application of two-dimensional speckle tracking imaging (2D-STI) in the follow-up of patients with coronary heart disease (CHD) who were treated with metalol. Methods: A total of 100 patients with CHD (CHD group) who were treated with metalol and had undergone percutaneous coronary intervention (PCI) at Tangshan Works’ Hospital, Tangshan, China, and another 100 healthy people (control group) were enrolled in this study. Prior to and after 6 months of treatment, echocardiography was performed on patients in control and CHD groups, respectively, and the wall motion score was calculated. The 2D-STI was used to obtain systolic peak longitudinal strain value (SLs), global peak longitudinal strain (GSL) and early diastolic peak longitudinal strain rate (SrLe) in the early diastolic period of 6 wall basal segments, middle segments, and apical segments of the left ventricle. Results: The wall motion score index (WMSI) of CHD group was higher than that of the control group, while the WMSI of CHD group after treatment was significantly lower than the value before treatment, (p < 0.05). In 2D-STI, the SLs, SrLe and GLS of patients after 6 months of treatment were significantly higher than those before treatment (p < 0.05).Conclusion: Thus, 2D-STI can be used to quantify the motion of the chamber wall and the effect of PCI surgery, and it also provides a stable new index and technique for evaluating the effects of treatment of CHD.
Determination of allyl isothiocyanate from Hedyotis herbacea and its in silico screening for wound healing activity
Authors: Anand Babu K , Sivakrishnan S , Jasemine S
Published: May 2023

No Abstract.
ANKRD22 enhances cancer stem cell growth and cisplatin resistance in cervical cancer via NUSAP1/Wnt/β catenin pathway
Authors: Pan Dan , Ye Wenwei , Qiu Xiaoxiao , Wang Yaxian
Published: May 2023

Purpose: To investigate the role of ankyrin repeat domain 22 (ANKRD22) and nucleolar spindle-associated protein 1 (NUSAP1)-mediated Wnt/β-catenin pathway in cervical cancer (CC). Methods: ANKRD22 levels were evaluated in tissue samples collected from CC patients. The CC cells were transfected with an ANKRD22 silencing vector. Cell proliferation and migration were determined via colony formation, BrdU, scratch and Transwell assays. Sphere formation test was performed to determine the effect of ANKRD22 on the cancer stem cell (CSC)-like traits of CC cells. The effect of ANKRD22 on CSC-like traits was further evaluated by determining the expressions of the CSC markers, Oct4, SOX2, and Nanog, while cisplatin resistance was assessed by CCK-8 assay. The effect of ANKRD22 on the NUSAP1-mediated Wnt/β-catenin pathway was evaluated by determining the expression levels of β-catenin, matrix metalloproteinase-7, and adenomatous polyposis coli. Moreover, ANKRD22-mediated tumor growth was monitored in vivo using an animal model. Results: ANKRD22 was overexpressed in cancer tissues from CC patients (p < 0.05). ANKRD22 knockdown suppressed CC cell proliferation, migration, invasion, and CSC traits, and also positively regulated Wnt/β-catenin pathway through NUSAP1 (p < 0.05). However, the inhibition of ANKRD22 suppressed tumor growth in vivo through NUSAP1. In addition, the silencing of ANKRD22 alleviated cisplatin resistance in CC cells (p < 0.05). Conclusion: ANKRD22 activates NUSAP1/Wnt/β-catenin pathway, and enhances CSC-like characteristics and cisplatin resistance, thus exacerbating the malignant behaviors of CC cells. Therefore, ANKRD22 could serve as a promising target for CC treatment.
Medicines of Language: Ecosomatic Poetics and Embodied Practice.
Authors:   , Prevallet Kristin
Published: May 2023

The aim of this thesis, written to satisfy the degree requirements for a PhD by publication, is to present the theoretical framework, methodologies, findings and impact of my 25 years of research (books, essays, articles, performances and poems published in literary magazines) in order to demonstrate its originality and contribution to the knowledge and practice of Ecosomatic poetics. Through creative and scholarly outputs, my research over the past 25 years has been to demonstrate how language is an embodied field of somatic awareness. Drawing on somatic phenomenology, psychosomatic psychology, and conceptual poetics, this thesis presents the key findings of the research including insights into relationships between poetic language and the innate healing capacities of the bodymind system as it relates to corresponding ecologies. Although it is my hope that this thesis reveals ways that Ecosomatic poetics might contribute to larger methods and philosophies surrounding mental health and somatic healing modalities, I am not attempting to prove or quantify any medical claim or posit any miracle cure in this document. As poet Tyrone Williams writes in his generous impact statement, “Kristin’s writings are the at the forefront of current social, cultural and political movements driven by an understanding that the very notion of the human ‘body,’ and perhaps the human itself, must be rethought, reconceptualized, beyond and above Cartesian dualisms.” Indeed, this thesis and corresponding bibliography posits a poetics of reading and writing in which language itself is conceptualized as medicine, embodiment, and energy.
Lo divino como posibilidad de superación del racionalismo ilustrado en el pensamiento de María Zambrano (1904-1991)
Authors: Núñez Aguilera Miguel Ángel
Published: May 2023

Dentro de las diversas visiones críticas que de la modernidad se han realizado a lo largo del siglo XX, la malagueña María Zambrano nos ofrece una reflexión original y sugerente sobre el significado y la transcendencia del descubrimiento cartesiano del existente humano como cogito. El hombre nacido de la modernidad ha experimentado una merma progresiva y honda de la amplitud de su ser persona a favor de una consideración de sujeto; con ello, también la realidad ha quedado reducida a mero objeto de razón. El resultado es un hombre abismado, que vive de espaldas a la realidad, y por tanto enemistado con la verdad tal como ella se ofrece en lo real, y en consecuencia cerrado desde dentro a la transcendencia. Frente a los postulados de la modernidad, Zambrano desarrolla una razón radicalmente abierta a la vida y constituida en trascendencia.
Alegoría del mal gobierno. Tiranía y violencia
Authors: Palma Ramírez Manuel
Published: May 2023

En aras de poner en relación en un marco reflexivo la forma de gobierno tiránica con el ejercicio de la violencia, es preciso adentrarse en los orígenes mismos de la consideración filosófica de la tiranía. La tiranía, en el sentido que la Grecia antigua le dio, no es sino el régimen de poder absoluto, de ordinario unipersonal, que con frecuencia instauraba el tirano, aquél o aquellos que habían derrocado el gobierno de una ciudad-estado, normalmente gracias al apoyo popular, pero también mediante un golpe de estado militar o una intervención extranjera. De esta noción clásica de tiranía se derivan algunos elementos importantes de los que se hará eco este escrito. En un primer momento, después de haber considerado la perspectiva de estudio (1), se situará el origen de la tiranía en su relación con un momento de crisis: este vínculo hace de ella una especie de medicina que pretende remediar un mal, como si de la cura de una enfermedad se tratase (2); a continuación, se establecerá el pasaje desde una percepción positiva de  tiranía hacia una determinación peyorativa del término (3); y, por último, se abordará la crisis de la tiranía y la oposición popular violenta que ella suscita (4). Las conclusiones serán presentadas a la luz del fresco de A. Lorenzetti, Alegoría del mal gobierno (5).
Nuevas precisiones artísticas sobre el tesoro catedralicio hispalense (I): El cáliz y el copón de oro y piedras preciosas
Authors: Gil Pineda Francisco M.
Published: May 2023

Entre las valiosas piezas que conforman el rico tesoro de la catedral hispalense destacan un cáliz y un copón de oro y piedras preciosas, joyas sobre las que existen pocas y confusas noticias. En este artículo se aclaran definitivamente diversos aspectos sobre su origen, autoría y ejecución
Por la senda luminosa de un camino abandonado: Via Pulchritudinis y metafísica
Authors: Palma Ramírez Manuel
Published: May 2023

Los rasgos fundamentales de la Belleza, tal como fueron presentados en la filosofía de Santo Tomás de Aquino (armonía, integridad y esplendor), permiten establecer conexiones con la Verdad, el Bien y la Bondad. Volver a recorrer la via pulchritudinis trae consigo la recuperación del Ser mismo, de la Metafísica. La nueva evangelización tiene en la Belleza uno de sus referentes fundamentales para avanzar hacia Dios, comprender el misterio de Cristo y la santidad eclesial.
El tiempo en San Agustín: ¿Lamento o esperanza?
Authors: Morillo Rey Pablo
Published: May 2023

A lo largo de la historia de la humanidad, siempre se ha planteado el problema del tiempo como algo constante y perenne. Así, autores como Ortega y Gasset, Heidegger o Unamuno, entre otros, ya intentaron ofrecer una respuesta sólida y convincente ante tan angustiosa cuestión. Pero, mucho antes, ya San Agustín atisbó en el Siglo IV una doble vertiente: por un lado, el tiempo puede ser visto desde el prisma del lamento, la angustia (pues todo –incluido el ser humano– es “presa de las fauces temporales”) o bajo la esperanza y la expectación (pues a lo largo de su transcurso, el hombre puede ir creciendo y progresando). No obstante, la complejidad temporal es tal que –como ya bien se verá a lo largo de este artículo– hemos de estructurar su análisis en cuatro fases: 1) Tiempo psicológico; 2) Tiempo físico; 3) Tiempo moral y 4) Tiempo histórico.
Spatial Water Quality Characteristics of Kallayi River Basin in GIS Platform
Authors: . Nadeeda , P Binisha
Published: May 2023

Kallayi River is a small river situated in the Kozhikode district of Kerala.it is well known for its timber business. This river is being polluted by these timber businesses and other human activities. This paper deals with the water quality analysis of river Kallayi in post-monsoon and premonsoon seasons and assesses the water quality index using the CCME method and GIS mapping. The parameters analyzed are pH, turbidity, chloride, DO, BOD, COD, E coli, and total coliform.