bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotional Intelligence and Mental Health in the Family: The Influence of Emotional Intelligence Perceived by Parents and Children
Authors: Sánchez-Núñez María Trinidad , García-Rubio Noelia , Fernández-Berrocal Pablo , Latorre José Miguel
Published: August 2020

Introduction: The relevant scientific literature has confirmed the relationship between emotional intelligence (EI) and mental health. In addition, previous studies have underlined the importance of perceived EI between family members in the construction of one’s own EI. Adolescence is considered to be a crucial stage in identity construction and a time when mental health is vulnerable. Objectives: To analyze the mediating role of self-reported EI on mental health of adolescents and young adults still living in the family home, we considered the relationship between perceived EI in parents and children. Method: The sample was comprised of 170 children and their respective fathers and mothers living in the same family home. Self-reported EI was evaluated using the Trait Meta-Mood Scale (TMMS-24), whereas perceived EI was evaluated via the Perceived Emotional Intelligence Scale-24 (PTMM-24) and mental health using the MH-5. Results: Parents’ perceived EI of their children also children’s perceived EI of their parents has a direct effect on children’s mental health and an indirect effect through the EI self-reported by children. We discuss the differences in the role of mothers and fathers in emotional education and its influence on the results. Conclusions: We highlight the importance of perceived EI among family members, over and above the self-reported EI of each member, for its predictive power on the mental health of children.
The Prevalence of Anticholinergic Drugs and Correlation with Pneumonia in Elderly Patients: A Population-Based Study in Taiwan
Authors: Lee Chien-Ying , Cheng Yih-Dih , Cheng Wei-Yuan , Tsai Tung-Han , Huang Kuang-Hua
Published: August 2020

Anticholinergic drugs may increase the risk of serious respiratory infection, especially in the elderly. The study aims to investigate the prevalence of anticholinergic drugs and the correlation of incident pneumonia associated with the use of anticholinergic drugs among the elderly in Taiwan. The study population was 275,005 elderly patients aged ≥65 years old, selected from the longitudinal health insurance database (LHID) in 2016. Among all the elderly patients, about 60% had received anticholinergic medication at least once. Furthermore, the study selected elderly patients who had not been diagnosed with pneumonia and had not received any anticholinergic drugs in the past year in order to evaluate the correlation between pneumonia and anticholinergic drugs. The study excluded elderly patients who died or had received related drugs of incident pneumonia during the study period and selected elderly patients receiving anticholinergic drugs as the case group. Propensity score matching (PSM) on a 1:1 scale was used to match elderly patients that were not receiving any anticholinergic drugs as the control group, resulting in a final sample of 32,215 patients receiving anticholinergic drugs and 32,215 patients not receiving any anticholinergic drugs. Conditional logistic regression was used to estimate the association between anticholinergic drugs and pneumonia after controlling for potential confounders. Compared with patients not receiving anticholinergic drugs, the adjusted odds ratio of patients receiving anticholinergic drugs was 1.33 (95% confidence interval: 1.18 to 1.49). Anticholinergic medication is common among elderly patients in Taiwan. Elderly patients receiving anticholinergic drugs may increase their risk of incident pneumonia. The safety of anticholinergic drugs in the elderly should be of concern in Taiwan.
The WHO and UNICEF Joint Monitoring Programme (JMP) Indicators for Water Supply, Sanitation and Hygiene and Their Association with Linear Growth in Children 6 to 23 Months in East Africa
Authors: Rakotomanana Hasina , Komakech Joel J. , Walters Christine N. , Stoecker Barbara J.
Published: August 2020

The slow decrease in child stunting rates in East Africa warrants further research to identify the influence of contributing factors such as water, sanitation, and hygiene (WASH). This study investigated the association between child length and WASH conditions using the recently revised WHO and UNICEF (United Nations Children’s Fund) Joint Monitoring Programme (JMP) indicators. Data from households with infants and young children aged 6–23 months from the Demographic and Health Surveys in Burundi, Ethiopia, Kenya, Malawi, Rwanda, Tanzania, Uganda, and Zambia were used. Associations for each country between WASH conditions and length-for-age z-scores (LAZ) were analyzed using linear regression. Stunting rates were high (>20%) reaching 45% in Burundi. At the time of the most recent Demographic and Health Survey (DHS), more than half of the households in most countries did not have basic or safely managed WASH indicators. Models predicted significantly higher LAZ for children living in households with safely managed drinking water compared to those living in households drinking from surface water in Kenya (β = 0.13, p < 0.01) and Tanzania (β = 0.08, p < 0.05) after adjustment with child, maternal, and household covariates. Children living in households with improved sanitation facilities not shared with other households were also taller than children living in households practicing open defecation in Ethiopia (β = 0.07, p < 0.01) and Tanzania (β = 0.08, p < 0.01) in the adjusted models. All countries need improved WASH conditions to reduce pathogen and helminth contamination. Targeting adherence to the highest JMP indicators would support efforts to reduce child stunting in East Africa.
Mortality among Fire Department of the City of New York Rescue and Recovery Workers Exposed to the World Trade Center Disaster, 2001–2017
Authors: Colbeth Hilary , Zeig-Owens Rachel , Hall Charles , Webber Mayris , Schwartz Theresa , Prezant David
Published: August 2020

The World Trade Center (WTC) attacks on 9/11/2001 have consistently been associated with elevated rates of physical and mental health morbidities, while evidence about mortality has been limited. We examined mortality between 9/12/2001 and 12/31/2017 among 15,431 WTC-exposed Fire Department of the City of New York (FDNY) firefighters and emergency medical service providers (EMS), specifically assessing associations between intensity of WTC-exposure and mortality risk. Standardized mortality ratios (SMR) and 95% confidence intervals (CI) compared FDNY cohort mortality with the US general population using life table analysis. Deaths were identified via linkage to the National Death Index. Cox proportional hazards regression models were used to identify associations between intensity of WTC-exposure and mortality, accounting for age, sex, race/ethnicity, smoking history, and other relevant confounders. We identified 546 deaths and a lower than expected all-cause mortality rate (SMR = 0.34; 95% CI, 0.31–0.37). No cause-specific SMRs were meaningfully elevated. Mortality hazard ratios showed no association or linear trend with level of WTC-exposure. Our results provide evidence of the healthy worker effect, despite exposure to the World Trade Center. More follow-up time may be needed to assess the full impact of WTC-exposure on mortality in this occupational population.
Implementation Models of Compassionate Communities and Compassionate Cities at the End of Life: A Systematic Review
Authors: Librada-Flores Silvia , Nabal-Vicuña María , Forero-Vega Diana , Muñoz-Mayorga Ingrid , Guerra-Martín María Dolores
Published: August 2020

In the last decade, we have seen a growth of Compassionate Communities and Cities (CCC) at the end of life. There has been an evolution of organizations that help construct Community-Based Palliative Care programs. The objective is to analyze the implementation, methodology and effectiveness of the CCC models at the end of life. We conducted a systematic review following PRISMA ScR Guideline. The protocol was registered on PROSPERO (CRD42017068501). Five databases (MEDLINE, EMBASE, Web of Science, CINAHL and Google Scholar) were searched for studies (from 2000 to 2018) using set eligibility criteria. Three reviewers screened full-texts articles and extracted study data. Outcomes were filled in a registration form which included a narrative synthesis of each article. We screened 1975 records. We retrieved 112 articles and included 31 articles for the final analysis: 17 descriptive studies, 4 interventions studies, 4 reviews and 6 qualitative studies. A total of 11 studies regard the development models of CCC at the end of life, 15 studies were about evaluation of compassionate communities’ programs and 5 studies were about protocols for the development of CCC programs. There is poor evidence of the implementation and evaluation models of CCC at the end of life. There is little and low-/very low-quality evidence about CCC development and assessment models. We found no data published on care intervention in advance disease and end of life. A global model for the development and evaluation of CCC at the end of life seems to be necessary.
Pollution, Health, and the Moderating Role of Physical Activity Opportunities
Authors: Cunningham George B. , Wicker Pamela , McCullough Brian P.
Published: August 2020

Air and water pollution have detrimental effects on health, while physical activity opportunities have a positive relationship. The purpose of this study was to explore whether physical activity opportunities moderate the relationships among air and water pollution, and measures of health. Aggregate data were collected at the county level in the United States (n = 3104). Variables included the mean daily density of fine particle matter (air pollution), reported cases of health-related drinking water violations (water pollution), subjective ratings of poor or fair health (overall health), the number of physically and mentally unhealthy (physical and mental health, respectively), and the percentage of people living in close proximity to a park or recreation facility (access to physical activity). Air and water pollution have a significant positive effect on all measures of residents’ poor health, while physical activity opportunities only have a negative effect on overall health and physical health. Access to physical activity only moderates the relationship between air pollution and all health outcomes. Since physical activity behavior can be more rapidly changed than some causes of pollution, providing the resident population with better access to physical activity can represent an effective tool in environmental health policy.
Effects of Aerobic and Anaerobic Fatigue Exercises on Postural Control and Recovery Time in Female Soccer Players
Authors: Güler Özkan , Aras Dicle , Akça Fırat , Bianco Antonino , Lavanco Gioacchino , Paoli Antonio , Şahin Fatma Neşe
Published: August 2020

Sixteen female soccer players (age = 20.19 ± 1.52 years; body mass = 56.52 ± 4.95 kg; body height = 164.81 ± 4.21 cm) with no history of lower extremity injury participated in the study. The Biodex SD Balance system was used to determine the non-dominant single-leg stability. In anaerobic exercise, each subject performed four maximal cycling efforts against a resistance equivalent to 0.075 kg/body mass for 30 s with three-minute rest intervals. In aerobic exercise, subjects performed the Bruce protocol on a motorized treadmill. After each exercise, subjects subsequently performed a single-leg stability test and then repeated the same test for four times with five-minute passive rest periods. In accordance with the results, it was found that the impairment observed right after the aerobic loading was higher (p < 0.001) compared to the anaerobic one. However, the time-related deterioration in both aerobic and anaerobic loadings was similar. The B-pre value was lower than Bpost and B5 (p < 0.01) and B10 (p < 0.05) in both conditions. Subjects could reach the initial balance level at B15 after aerobic and anaerobic loadings. The lactate level did not reach resting value even after 20 min of both fatigue protocols. Although the fatigue after aerobic and aerobic exercise negatively affects a single-leg dynamic balance level, single leg balance ability returns to the baseline status after 10 min of passive recovery duration.
Occupational Noise and Hypertension Risk: A Systematic Review and Meta-Analysis
Authors: Bolm-Audorff Ulrich , Hegewald Janice , Pretzsch Anna , Freiberg Alice , Nienhaus Albert , Seidler Andreas
Published: August 2020

A number of epidemiological studies report an association between occupational noise exposure and arterial hypertension. Existing systematic reviews report conflicting results, so we conducted an updated systematic review with meta-analysis. We registered the review protocol with PROSPERO (registration no.: CRD 42019147923) and searched for observational epidemiological studies in literature databases (Medline, Embase, Scopus, Web of Science). Two independent reviewers screened the titles/abstracts and full texts of the studies. Two reviewers also did the quality assessment and data extraction. Studies without adequate information on recruitment, response, or without a comparison group that was exposed to occupational noise under 80 dB(A) were excluded. The literature search yielded 4583 studies, and 58 studies were found through hand searching. Twenty-four studies were included in the review. The meta-analysis found a pooled effect size (ES) for hypertension (systolic/diastolic blood pressure ≥140/90 mmHg) due to noise exposures ≥80 dB(A) of 1.81 (95% CI 1.51–2.18). There is no substantial risk difference between men and women, but data concerning this question are limited. We found a positive dose-response-relationship: ES = 1.21 (95% CI 0.78–1.87) ≤ 80 dB(A), ES = 1.77 (95% CI 1.36–2.29) > 80–≤85 dB(A), and ES = 3.50 (95% CI 1.56–7.86) > 85–≤90 dB(A). We found high quality of evidence that occupational noise exposure increases the risk of hypertension.
Exploration of Alcohol Consumption Behaviours and Health-Related Influencing Factors of Young Adults in the UK
Authors: Bhatti Sunbal Naureen , Fan Lampson M. , Collins Adam , Li Jian-Mei
Published: August 2020

Hazardous alcohol consumption is ranked above illicit drug use with regards to health deterioration and social and economic burden. This study sought to clarify the factors influencing alcohol consumption and its prevalence in young adults. Demographics, alcohol consumption and lifestyle information were gathered via anonymous questionnaires during 2011–2019, crossing Reading, Surrey and Farnborough universities, UK. Controlling for confounders, a multinomial logistic regression was performed using SAS® 9.4 software. A total of 1440 students (43.5% males, 56.5% females; 54.4% Caucasians) with a mean (SD) age of 19.9 (2.73) were included. Among them, 68.9% consumed alcohol frequently and 31.7% had ≥12 units/week. Statistical analysis revealed that males consumed twice more alcohol than females, odds ratio (OR) 1.67 (95% confidence interval (CI) = 1.34–2.09), p-value < 0.01. Caucasians consumed up to five times more alcohol than other ethnicities, OR 4.55 (3.57–5.56), p-value < 0.01. Smokers consumed three times more alcohol than non-smokers, OR 2.69 (1.82, 3.99), p-value < 0.01. In general, the levels of alcohol consumption were positively associated with the levels of physical activity, OR 2.00 (1.17–3.42), p-value < 0.05 and negatively associated with recreational sedentary screen-time activities in males, OR 0.31 (0.12–0.86), p-value = 0.03. Focusing alcohol interventions toward Caucasians, smokers and physically active students, particularly males, may guide university strategies to reduce alcohol-related societal harm and risks of morbidity and mortality.
How Can We Improve the Consumption of a Nutritionally Balanced Maternal Diet in Rural Bangladesh? The Key Elements of the “Balanced Plate” Intervention
Authors: Alam Ashraful , Chowdhury Morseda , Dibley Michael J. , Raynes-Greenow Camille
Published: August 2020

Social, cultural, environmental and economic factors closely regulate the selection, allocation and consumption of maternal diets. We developed a nutrition behaviour change intervention to promote a balanced diet in pregnancy through practical demonstration in rural Bangladesh and tested the impact with a cluster randomised controlled trial. This paper presents the findings of the process evaluation and describes the strategies that worked for intervention compliance. We conducted in-depth interviews with pregnant women, women who birthed recently, and their husbands; focus groups with mothers and mothers-in-law; key-informant interviews with community health workers, and observations of home visits. We identified six key areas within the intervention strategy that played a crucial role in achieving the desired adherence. These included practical demonstration of portion sizes; addressing local food perceptions; demystifying animal-source foods; engaging husbands and mothers-in-law; leveraging women’s social networks; and harnessing community health workers’ social role. Practical demonstration, opportunity to participate and convenience of making of the plate with the food available in their kitchen or neighbours’ kitchen were the most commonly mentioned reasons for acceptance of the intervention by the women and their families. The balanced plate intervention helped women through practical demonstration to learn about a balanced meal by highlighting appropriate portion sizes and food diversity. The women needed active involvement of community health workers in mobilising social support to create an enabling environment essential to bring changes in dietary behaviours. Future implementation of the intervention should tailor the strategies to the local context to ensure optimal adherence to the intervention.
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles
Authors: Do Ha Thi Thu , Cho Jungsook
Published: August 2020

Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression are growing burdens for society globally, partly due to a lack of effective treatments. Mangosteen (Garcinia mangostana L.,) pericarp (MP) and its xanthones may provide therapeutic advantages for these disorders. In this review, we discuss potential therapeutic value of MP-derived agents in AD, PD, and depression with their pharmacokinetic and safety profiles. MP-derived agents have shown multifunctional effects including neuroprotective, antioxidant, and anti-neuroinflammatory actions. In addition, they target specific disease pathologies, such as amyloid beta production and deposition as well as cholinergic dysfunction in AD; α-synuclein aggregation in PD; and modulation of monoamine disturbance in depression. Particularly, the xanthone derivatives, including α-mangostin and γ-mangostin, exhibit potent pharmacological actions. However, low oral bioavailability and poor brain penetration may limit their therapeutic applications. These challenges can be overcome in part by administering as a form of MP extract (MPE) or using specific carrier systems. MPE and α-mangostin are generally safe and well-tolerated in animals. Furthermore, mangosteen-based products are safe for humans. Therefore, MPE and its bioactive xanthones are promising candidates for the treatment of AD, PD, and depression. Further studies including clinical trials are essential to decipher their efficacy, and pharmacokinetic and safety profiles in these disorders.
GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies
Authors: Leal Andrés Felipe , Benincore-Flórez Eliana , Solano-Galarza Daniela , Garzón Jaramillo Rafael Guillermo , Echeverri-Peña Olga Yaneth , Suarez Diego A. , Alméciga-Díaz Carlos Javier , Espejo-Mojica Angela Johana
Published: August 2020

GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside accumulation into the lysosome due to mutations on the genes encoding for the β-hexosaminidases subunits or the GM2 activator protein. Three GM2 gangliosidoses have been described: Tay–Sachs disease, Sandhoff disease, and the AB variant. Central nervous system dysfunction is the main characteristic of GM2 gangliosidoses patients that include neurodevelopment alterations, neuroinflammation, and neuronal apoptosis. Currently, there is not approved therapy for GM2 gangliosidoses, but different therapeutic strategies have been studied including hematopoietic stem cell transplantation, enzyme replacement therapy, substrate reduction therapy, pharmacological chaperones, and gene therapy. The blood–brain barrier represents a challenge for the development of therapeutic agents for these disorders. In this sense, alternative routes of administration (e.g., intrathecal or intracerebroventricular) have been evaluated, as well as the design of fusion peptides that allow the protein transport from the brain capillaries to the central nervous system. In this review, we outline the current knowledge about clinical and physiopathological findings of GM2 gangliosidoses, as well as the ongoing proposals to overcome some limitations of the traditional alternatives by using novel strategies such as molecular Trojan horses or advanced tools of genome editing.
Peripheral Mechanobiology of Touch—Studies on Vertebrate Cutaneous Sensory Corpuscles
Authors: Cobo Ramón , García-Piqueras Jorge , García-Mesa Yolanda , Feito Jorge , García-Suárez Olivia , Vega Jose A
Published: August 2020

The vertebrate skin contains sensory corpuscles that are receptors for different qualities of mechanosensitivity like light brush, touch, pressure, stretch or vibration. These specialized sensory organs are linked anatomically and functionally to mechanosensory neurons, which function as low-threshold mechanoreceptors connected to peripheral skin through Aβ nerve fibers. Furthermore, low-threshold mechanoreceptors associated with Aδ and C nerve fibers have been identified in hairy skin. The process of mechanotransduction requires the conversion of a mechanical stimulus into electrical signals (action potentials) through the activation of mechanosensible ion channels present both in the axon and the periaxonal cells of sensory corpuscles (i.e., Schwann-, endoneurial- and perineurial-related cells). Most of those putative ion channels belong to the degenerin/epithelial sodium channel (especially the family of acid-sensing ion channels), the transient receptor potential channel superfamilies, and the Piezo family. This review updates the current data about the occurrence and distribution of putative mechanosensitive ion channels in cutaneous mechanoreceptors including primary sensory neurons and sensory corpuscles.
Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective
Authors: Smolková Barbora , Frtús Adam , Uzhytchak Mariia , Lunova Mariia , Kubinová Šárka , Dejneka Alexandr , Lunov Oleg
Published: August 2020

The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments.
CRISPR-Cas9 DNA Base-Editing and Prime-Editing
Authors: Kantor Ariel , McClements Michelle , MacLaren Robert
Published: August 2020

Many genetic diseases and undesirable traits are due to base-pair alterations in genomic DNA. Base-editing, the newest evolution of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based technologies, can directly install point-mutations in cellular DNA without inducing a double-strand DNA break (DSB). Two classes of DNA base-editors have been described thus far, cytosine base-editors (CBEs) and adenine base-editors (ABEs). Recently, prime-editing (PE) has further expanded the CRISPR-base-edit toolkit to all twelve possible transition and transversion mutations, as well as small insertion or deletion mutations. Safe and efficient delivery of editing systems to target cells is one of the most paramount and challenging components for the therapeutic success of BEs. Due to its broad tropism, well-studied serotypes, and reduced immunogenicity, adeno-associated vector (AAV) has emerged as the leading platform for viral delivery of genome editing agents, including DNA-base-editors. In this review, we describe the development of various base-editors, assess their technical advantages and limitations, and discuss their therapeutic potential to treat debilitating human diseases.
A Note on Ultrametric Spaces, Minimum Spanning Trees and the Topological Distance Algorithm
Authors: Schäfer Jörg
Published: August 2020

We relate the definition of an ultrametric space to the topological distance algorithm—an algorithm defined in the context of peer-to-peer network applications. Although (greedy) algorithms for constructing minimum spanning trees such as Prim’s or Kruskal’s algorithm have been known for a long time, they require the complete graph to be specified and the weights of all edges to be known upfront in order to construct a minimum spanning tree. However, if the weights of the underlying graph stem from an ultrametric, the minimum spanning tree can be constructed incrementally and it is not necessary to know the full graph in advance. This is possible, because the join algorithm responsible for joining new nodes on behalf of the topological distance algorithm is independent of the order in which the nodes are added due to the property of an ultrametric. Apart from the mathematical elegance which some readers might find interesting in itself, this provides not only proofs (and clearer ones in the opinion of the author) for optimality theorems (i.e., proof of the minimum spanning tree construction) but a simple proof for the optimality of the reconstruction algorithm omitted in previous publications too. Furthermore, we define a new algorithm by extending the join algorithm to minimize the topological distance and (network) latency together and provide a correctness proof.
Identification of a Plasma Microrna Signature as Biomarker of Subaneurysmal Aortic Dilation in Patients with High Cardiovascular Risk
Authors: Torres-Do Rego Ana , Barrientos María , Ortega-Hernández Adriana , Modrego Javier , Gómez-Gordo Rubén , Álvarez-Sala Luis A. , Cachofeiro Victoria , Gómez-Garre Dulcenombre
Published: August 2020

Patients with subaneurysmal aortic dilation (SAD; 25–29 mm diameter) are likely to progress to true abdominal aortic aneurysm (AAA). Despite these patients having a higher risk of all-cause mortality than subjects with aortic size <24 mm, early diagnostic biomarkers are lacking. MicroRNAs (miRs) are well-recognized potential biomarkers due to their differential expression in different tissues and their stability in blood. We have investigated whether a plasma miRs profile could identify the presence of SAD in high cardiovascular risk patients. Using qRT-PCR arrays in plasma samples, we determined miRs differentially expressed between SAD patients and patients with normal aortic diameter. We then selected 12 miRs to be investigated as biomarkers by construction of ROC curves. A total of 82 significantly differentially expressed miRs were found by qPCR array, and 12 were validated by qRT-PCR. ROC curve analyses showed that seven selected miRs (miR-28-3p, miR-29a-3p, miR-93-3p, miR-150-5p, miR-338-3p, miR-339-3p, and miR-378a-3p) could be valuable biomarkers for distinguishing SAD patients. MiR-339-3p showed the best sensitivity and specificity, even after combination with other miRs. Decreased miR-339-3p expression was associated with increased aortic abdominal diameter. MiR-339-3p, alone or in combination with other miRs, could be used for SAD screening in high cardiovascular risk patients, helping to the early diagnosis of asymptomatic AAA.
High Prevalence of Intestinal Pathogens in Indigenous in Colombia
Authors: Kann Simone , Bruennert Daniela , Hansen Jessica , Mendoza Gustavo Andrés Concha , Gonzalez José José Crespo , Quintero Cielo Leonor Armenta , Hanke Miriam , Hagen Ralf Matthias , Backhaus Joy , Frickmann Hagen
Published: August 2020

Background: Intestinal infections remain a major public health burden in developing countries. Due to social, ecological, environmental, and cultural conditions, Indigenous peoples in Colombia are at particularly high risk. Materials: 137 stool samples were analyzed by microscopy and real-time-Polymerase Chain Reaction (RT-PCR), targeting protozoan parasites (Giardia intestinalis, Entamoeba histolytica, Cryptosporidium spp., and Cyclospora cayetanensis), bacteria (Campylobacter jejuni, Salmonella spp., Shigella ssp./enteroinvasive E. coli (EIEC), Yersinia spp., enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), enterotoxin-producing E. coli (ETEC), enteroaggregative E. coli (EAEC), and Tropheryma whipplei), and helminths (Necator americanus, Strongyloides stercoralis, Ascaris lumbricoides, Ancylostoma spp., Trichuris. trichiura, Taenia spp., Hymenolepis nana, Enterobius vermicularis, and Schistosoma spp.). Microscopy found additional cases of helminth infections. Results: At least one pathogen was detected in 93% of the samples. The overall results revealed protozoa in 79%, helminths in 69%, and bacteria in 41%. G. intestinalis (48%), Necator/hookworm (27%), and EAEC (68%) were the most common in each group. Noteworthy, T. whipplei was positive in 7% and T. trichirua in 23% of the samples. A significant association of one infection promoting the other was determined for G. intestinalis and C. jejuni, helminth infections, and EIEC. Conclusions: The results illustrate the high burden of gastrointestinal pathogens among Indigenous peoples compared to other developing countries. Countermeasures are urgently required.
2-Butyl-6-phenyl-4,5-dihydropyridazin-3(2H)-one: Synthesis, In Silico Studies and In Vitro Cyclooxygenase-2 Inhibitory Activity
Authors: Imran Mohd
Published: August 2020

Pyridazinone derivatives are a great template for developing cyclooxygenase-2 (COX-2) inhibitors. The 2-butyl-6-phenyl-4,5-dihydropyridazin-3(2H)-one was prepared by reacting 6-phenyl-4,5-dihydropyridazin-3(2H)-one with n-butyl bromide in the presence of potassium carbonate. The structure of the compound was confirmed based on its FTIR, 1H-NMR, 13C-NMR, and Mass data. The molecular docking studies assessed the COX-2 binding capability of the synthesized compound. The in silico physicochemical and pharmacokinetic parameters of this compound concerning selected drugs were also calculated. The COX-2/COX-1 analysis revealed the synthesized compound as a novel potent COX-2 inhibitor, in comparison to indomethacin, with a promising physicochemical and pharmacokinetic profile.
Influence of Welding Speed on Characteristics of Non-Axisymmetric Laser-Tungsten Inert Gas Hybrid Welded Mg/Al Lap Joints with Zn Filler
Authors: Lv Xinze , Wang Hongyang , Liu Liming
Published: August 2020

A non-axisymmetric laser-tungsten inert gas (TIG) heat source was designed to join Mg–Al dissimilar metals with pure Zn filler at a series of welding speeds (500–900 mm/min). Laser and TIG heat sources respectively acted on Al and Mg base metals to precisely control their dissolution into the welding pool. The solidification rate of liquid metal was controlled by adjusting the welding speed, then the reaction process of Mg, Al and Zn could be accurately regulated. The results indicated that various microstructures including Al solid solution, Zn solid solution, Mg–Zn intermetallic compounds (IMCs) and eutectic structure formed in the joint produced at different speeds. Lower welding speed (500 mm/min) caused the microstructure coarsening and higher welding speed (900 mm/min) would lead to the enrichment of MgZn2 intermetallic compounds. At the optimal welding speed of 800 mm/min in particular, fine MgZn2 IMCs grains uniformly distributed in the Al and Zn solid solution. The tensile-shear load reached a maximum of 1052.5 N/cm and the joint fractured at the fusion zone near the Al base metal.
Development and Characterization of Clay–Nanocomposites for Water Purification
Authors: Asamoah Richard Barnes , Yaya Abu , Nbelayim Paschal , Annan Ebenezer , Onwona-Agyeman Boateng
Published: August 2020

In this work we propose a facile method of preparing cost-effective clay-metaloxide/metal (CuO/Ag and ZnO/Ag) composite pellets for an efficient water purification technique. Clay, with intrinsic antibacterial activity, served as a membrane support for different metaloxide/Ag nanoparticles (NPs) concentrations (2.5, 5 and 10 wt.%), as the active fillers. The effect of time (24 and 48 h) on the bactericidal activity of these pellets was also monitored. The clay–nanocomposite pellets were characterized using: X-ray diffraction, X-ray fluorescence, scanning electron microscopy, transmission electron microscopy, ultraviolet–visible (UV–Vis) spectrophotometry and nitrogen desorption analysis. The antibacterial activity performance was tested using E. coli and S. aureus strains of ATCC25922 and ATCC25923, respectively, in two aqueous media (nutrient broth and nutrient-free) by the colony-forming unit method. The results showed that the clay-CuO/Ag composite with a bandgap (1.24 eV) exhibited overall best performance under all conditions and time factors of ~100% efficiency in nutrient-free medium for all concentrations and times and 20–40% efficiency in nutrient broth for 24 h. The clay-ZnO/Ag with a bandgap of 2.88 eV showed no bactericidal activity in both media, except for that with 10 wt.% ZnO/Ag which showed 100% efficiency in nutrient-free medium after 24 h. All the synthesized composites showed 100% bactericidal efficiency in nutrient free medium after 48 h. These results indicate that, the clay/metaloxide/Ag could serve as efficient water purification technique, with a potential for large-scale commercialization.
Mesoporous Silica Nanoparticles in Bioimaging
Authors: Yuan Daohe , Ellis Connor M. , Davis Jason J.
Published: August 2020

A biomedical contrast agent serves to enhance the visualisation of a specific (potentially targeted) physiological region. In recent years, mesoporous silica nanoparticles (MSNs) have developed as a flexible imaging platform of tuneable size/morphology, abundant surface chemistry, biocompatibility and otherwise useful physiochemical properties. This review discusses MSN structural types and synthetic strategies, as well as methods for surface functionalisation. Recent applications in biomedical imaging are then discussed, with a specific emphasis on magnetic resonance and optical modes together with utility in multimodal imaging.
Influence of Crack Width on Chloride Penetration in Concrete Subjected to Alternating Wetting–Drying Cycles
Authors: Lai Jun , Cai Jian , Chen Qing-Jun , He An , Wei Mu-Yang
Published: August 2020

To investigate the durability of reinforced concrete (RC) beams under the combined actions of transverse cracks and corrosion, corrosion tests were conducted on a total of eight RC beams with different water–cement ratios and cracking states. The effects of the transverse crack width, water–cement ratio, and the length of the wetting–drying cycle on the distribution of the free chloride concentration, the cross-sectional loss of the tensile steel bars, and the chloride diffusion coefficient are analyzed. The results show that the widths of the transverse crack and the water–cement ratio of concrete greatly affected the chloride profile and content of the RC beam specimens. Specifically, the chloride contents in all the cracked RC beams at the depth of the steel bar exceeded the threshold value of 0.15%. As the width of the cracks increased, the chloride concentration and penetration of the cracked concrete beam increased. However, the chloride concentration at the reinforcement position did not seem to be obviously affected by increasing the wetting–drying cycles from 182 days to 364 days. Moreover, the decrease of the water–cement ratio effectively inhibited the penetration of chloride ions in the RC beam specimens. In terms of the cross-sectional loss of the steel bars, the average loss of the steel bar increases with increasing crack width for the beams with 182-day cycles, while the effect of crack width on the average loss is not as noticeable for the beams with 364-day cycles. Finally, a model is proposed to predict the relationship between the crack width influence coefficient, μ, and the crack width, w, and this model shows good agreement with the experimental results.
Preview Tracking Control for Discrete-Time Multirate Systems: An Internal Model-Based Approach
Authors: Pan Yuedou , Pei Mengtong , Li Li , Lu Yanrong
Published: August 2020

This paper investigates the preview tracking problem for discrete-time multirate systems under the scenario of the external signals with amplitude non-attenuation. Since the input and the state cannot be measured at the same time, the multirate system is first lifted into the single-rate system. Noting that the external signals are previewable and their amplitudes are unattenuated, an auxiliary system with preview information and a dynamic compensator with internal model are introduced, respectively. On this basis, the preview tracking problem can be converted to the output regulation problem of an augmented system with the aid of the state augmentation technique. Through verifying the solvability of the output regulation problem, the sufficient conditions and the corresponding controller with preview action and feedforward compensation are presented for the output regulation problem as well as the original problem. Finally, a numeric simulation result is provided to verify the validity of the proposed method.
Progress on the Fabrication and Application of Electrospun Nanofiber Composites
Authors: Toriello Mariela , Afsari Morteza , Shon Ho , Tijing Leonard
Published: August 2020

Nanofibers are one of the most attractive materials in various applications due to their unique properties and promising characteristics for the next generation of materials in the fields of energy, environment, and health. Among the many fabrication methods, electrospinning is one of the most efficient technologies which has brought about remarkable progress in the fabrication of nanofibers with high surface area, high aspect ratio, and porosity features. However, neat nanofibers generally have low mechanical strength, thermal instability, and limited functionalities. Therefore, composite and modified structures of electrospun nanofibers have been developed to improve the advantages of nanofibers and overcome their drawbacks. The combination of electrospinning technology and high-quality nanomaterials via materials science advances as well as new modification techniques have led to the fabrication of composite and modified nanofibers with desired properties for different applications. In this review, we present the recent progress on the fabrication and applications of electrospun nanofiber composites to sketch a progress line for advancements in various categories. Firstly, the different methods for fabrication of composite and modified nanofibers have been investigated. Then, the current innovations of composite nanofibers in environmental, healthcare, and energy fields have been described, and the improvements in each field are explained in detail. The continued growth of composite and modified nanofiber technology reveals its versatile properties that offer alternatives for many of current industrial and domestic issues and applications.
Study on the Preparation and Properties of Talcum-Fly Ash Based Ceramic Membrane Supports
Authors: Cheng Chao , Fu Hongming , Wu Jun , Zhang Heng , Chen Haiping
Published: August 2020

Ceramic membrane method for moisture recovery from flue gas of thermal power plants is of considerable interest due to its excellent selection performance and corrosion resistance. However, manufacturing costs of commercial ceramic membranes are still relatively expensive, which promotes the development of new methods for preparing low-cost ceramic membranes. In this study, a method for the preparation of porous ceramic membrane supports is proposed. Low-cost fly ash from power plants is the main material of the membrane supports, and talcum is the additive. The fabrication process of the ceramic membrane supports is described in detail. The properties of the supports were fully characterized, including surface morphology, phase composition, pore diameter distribution, and porosity. The mechanical strength of the supports was measured. The obtained ceramic membrane supports displays a pore size of about 5 μm and porosity of 37.8%. Furthermore, the water recovery performance of the supports under different operating conditions was experimentally studied. The experimental results show that the recovered water flux varies with operating conditions. In the study, the maximum recovered water flux reaches 5.22 kg/(m2·h). The findings provide a guidance for the ceramic membrane supports application of water recovery from flue gas.
Immobilisation and Release of Radical Scavengers on Nanoclays for Chemical Reinforcement of Proton Exchange Membranes
Authors: Akrout Alia , Delrue Aude , Zatoń Marta , Duquet Fanny , Spanu Francesco , Taillades-Jacquin Mélanie , Cavaliere Sara , Jones Deborah , Rozière Jacques
Published: August 2020

Mechanical and chemical stability of proton exchange membranes are crucial requirements for the development of fuel cells for durable energy conversion. To tackle this challenge, bi-functional nanoclays grafted with amino groups and with embedded radical scavengers, that is, CeO2 nanoparticles were incorporated into Aquivion® ionomer. The composite membranes presented high proton conductivity and increased stability to radical attack compared to non-modified Aquivion membranes, demonstrating the effectiveness of the approach based on radical scavenger immobilisation and release from clay nanocontainers.
Towards Dry Machining of Titanium-Based Alloys: A New Approach Using an Oxygen-Free Environment
Authors: Maier Hans Jürgen , Herbst Sebastian , Denkena Berend , Dittrich Marc-André , Schaper Florian , Worpenberg Sebastian , Gustus René , Maus-Friedrichs Wolfgang
Published: August 2020

In the current study, the potential of dry machining of the titanium alloy Ti-6Al-4V with uncoated tungsten carbide solid endmills was explored. It is demonstrated that tribo-oxidation is the dominant wear mechanism, which can be suppressed by milling in an extreme high vacuum adequate (XHV) environment. The latter was realized by using a silane-doped argon atmosphere. In the XHV environment, titanium adhesion on the tool was substantially less pronounced as compared to reference machining experiments conducted in air. This goes hand in hand with lower cutting forces in the XHV environment and corresponding changes in chip formation. The underlying mechanisms and the ramifications with respect to application of this approach to dry machining of other metals are discussed.
Development of a Nakazima Test Suitable for Determining the Formability of Ultra-Thin Copper Sheets
Authors: Ayachi Nejia , Guermazi Noamen , Pham Cong Hanh , Manach Pierre-Yves
Published: August 2020

The objective is to propose an accurate method for determining the forming limit curves (FLC) for ultra-thin metal sheets which are complex to obtain with conventional techniques. Nakazima tests are carried out to generate the FLCs of a pure copper and a copper beryllium alloy with a thickness of 0.1 mm. Because of the very small thickness of the sheets, the standard devices and the know-how of this test are no longer valid. Consequently, new tools have been designed in order to limit friction effect. Two different methods are used and compared to estimate the necking: the position-dependent measurement method (ISO Standard 12004-2), and the time-dependent method based on the analysis of the derivatives of the planar strain field. It is shown that the ISO standard method underestimates the forming limit curves. As the results present non linear strain paths, a compensation method is applied to correct the FLCs for the tested materials, which combines the effects of curvature, nonlinear strain paths and pressure. The curvature effect for such thickness and punch diameter on the FLCs is weak. The results show that this procedure enables to obtain FLCs that are close to those determined by the reference Marciniak method, leading to a minimum in major strain that converges to the plane strain state.
Comparison of Mechanical Properties of Ni-Al-Bronze Alloy Fabricated through Wire Arc Additive Manufacturing with Ni-Al-Bronze Alloy Fabricated through Casting
Authors: Kim Jisun , Kim Jaewoong , Pyo Changmin
Published: August 2020

This study compared the mechanical properties of the NAB (Ni-Al-bronze) material fabricated using wire arc additive manufacturing (WAAM) technology with those of the cast NAB. Using a CMT (cold metal transfer) welding process, this study analyzed the bead shape for six welding conditions, determined an appropriate bead shape, and fabricated a square bulk NAB material using the bead shape. For a mechanical properties comparison, the study obtained two test specimens per welding direction from the fabricated bulk NAB material, and compared those with the cast NAB materials. In the tensile test, the deposited NAB material showed significantly better results than the cast NAB; furthermore, the deposited NAB material showed better performance than the cast NAB material in the Vickers hardness test, impact test and wear test. In addition, the deposited NAB showed anisotropy depending on the welding direction, and showed high tensile strength, hardness and shock absorption in the longitudinal direction of the welding line.
Melting and Flowing Behavior of Mold Flux in a Continuous Casting Billet Mold for Ultra-High Speed
Authors: Yang Jie , Chen Dengfu , Qin Fengting , Long Mujun , Duan Huamei
Published: August 2020

High casting speed coincides with the development trend of billet continuous casting, which significantly changes the casting characteristics. A mathematical model of the billet mold, which includes multiphase fluid flow, transient heat transfer, and solidification during ultra-high speed of the casting process was developed. The model is first applied to investigate the flow field of molten steel in the mold, studying the influence of steel flow upon the melting and flowing behavior of mold flux. The temperature and velocity distributions of the flux pool that formed above the molten steel surface are described. A parametric study on the melting temperature and viscosity of mold flux on liquid flux thickness and flow velocity is then carried out. Finally, the model is used to derive the relationship between interfacial tension and level fluctuations. The predictions provide an improved understanding of the melting and flowing behavior of mold flux in the billet mold and give the guidance for the design and optimization of mold flux for ultra-high speed of billet casting.