bluuebunny/crossref_metadata_2025 huggingface dataset:
microRNA profile of Hermetia illucens (black soldier fly) and its implications on mass rearing
Authors: DeRaedt Sarah , Bierman Anandi , van Heusden Peter , Richards Cameron , Christoffels Alan
Published: March 2022

The growing demands on protein producers and the dwindling available resources have made Hermetia illucens (the black soldier fly, BSF) an economically important species. Insights into the genome of this insect will better allow for robust breeding protocols, and more efficient production to be used as a replacement of animal feed protein. The use of microRNA as a method to understand how gene regulation allows insect species to adapt to changes in their environment, has been established in multiple species. The baseline and life stage expression levels established in this study, allow for insight into the development and sex-linked microRNA regulation in BSF. To accomplish this, microRNA was extracted and sequenced from 15 different libraries with each life stage in triplicate. Of the total 192 microRNAs found, 168 were orthologous to known arthropod microRNAs and 24 microRNAs were unique to BSF. Twenty-six of the 168 microRNAs conserved across arthropods had a statistically significant (p < 0.05) differential expression between Egg to Larval stages. The development from larva to pupa was characterized by 16 statistically significant differentially expressed microRNA. Seven and 9 microRNA were detected as statistically significant between pupa to adult female and pupa to adult male, respectively. All life stages had a nearly equal split between up and down regulated microRNAs. Ten of the unique 24 miRNA were detected exclusively in one life stage. The egg life stage expressed five microRNA (hil-miR-m, hil-miR-p, hil-miR-r, hil-miR-s, and hil-miR-u) not seen in any other life stages. The female adult and pupa life stages expressed one miRNA each hil-miR-h and hil-miR-ac respectively. Both male and female adult life stages expressed hil-miR-a, hil-miR-b, and hil-miR-y. There were no unique microRNAs found only in the larva stage. Twenty-two microRNAs with 56 experimentally validated target genes in the closely related Drosophila melanogaster were identified. Thus, the microRNA found display the unique evolution of BSF, along with the life stages and potential genes to target for robust mass rearing. Understanding of the microRNA expression in BSF will further their use in the crucial search for alternative and sustainable protein sources.
Situating zoonotic diseases in peacebuilding and development theories: Prioritizing zoonoses in Jordan
Authors: McAlester Jaclyn , Kanazawa Yuichiro
Published: March 2022

Zoonotic diseases are projected to be a serious public threat in the coming decades. In 2016, the World Health Organization (WHO) recommended that Jordan prioritize their list of zoonoses, partially in response to the influx of Syrian refugees. We write this paper to expand the One Health framework by situating zoonotic diseases in peacebuilding and development theories in order to prioritize zoonotic diseases in Jordan. We employ an explanatory sequential mixed methods approach to create a modified version of the Center for Disease Control’s (CDC) One Health Zoonotic Disease Prioritization (OHZDP) tool. We use an integrative literature review to develop a list of zoonoses to be prioritized. We expand the One Health framework by arguing health inequity is a form of violence, and thus promotion of health equity is a form of peacebuilding. We undertake thematic and statistical analyses to assess the 12 previously published OHZDP tools to evaluate necessity for change to the process given COVID-19 and the refugee situation in Jordan. In these analyses we use drivers of health indicators as measurements for peacebuilding and development, given these drivers are related to health inequities, to guide weighting of the criteria in our tool for Jordan. We apply our modified OHZDP tool to prioritize our disease list. We find it necessary to give socioeconomic factors greater consideration and to distribute weighting more evenly among all criteria within the tool when prioritizing zoonotic diseases in better reflect the Jordanian context and incorporate the refugee population. We find the priority zoonoses within Jordan to be bovine tuberculosis, brucellosis, and COVID-19, with most having a disproportionately negative impact on refugees. In Jordan’s case, zoonotic diseases represent an area where promoting social equity for individuals is essential to the larger society. In this sense managing zoonoses is an area uniquely suited for peacebuilding.
A TCR mimic monoclonal antibody for the HPV-16 E7-epitope p11-19/HLA-A*02:01 complex
Authors: Dao Tao , Mun Sungsoo , Korontsvit Tatyana , Khan Abdul G. , Pohl Mary Ann , White Thomas , Klatt Martin G. , Andrew David , Lorenz Ivo C. , Scheinberg David A.
Published: March 2022

More effective treatments are needed for human papilloma virus (HPV)-induced cancers despite HPV virus vaccination. The oncogenic HPV protein targets are currently undruggable and intracellular and therefore there are no antibodies to these targets. Here we report the discovery of TCR mimic monoclonal antibodies (TCRm mAb) specific for the HPV E7 protein p11-19, YMLDLQPET, when presented on the cell surface in the context of HLA-A*02:01 by use of human phage display libraries. One of the mAbs, 3F8, was able to specifically mediate T cell- redirected cytotoxicity, in a bispecific T cell engager (BiTE) form. While further studies are required to assess the therapeutic potential of this approach, the study provided the proof of concept that TCRm mAb could be a therapeutic strategy for HPV-induced human cancers.
Investigation of the incidence trend of follicular lymphoma from 2008 to 2017 in Taiwan and the United States using population-based data
Authors: Su Yu-Chieh , Chiu Brian Chih-Hung , Li Hung-Ju , Yang Wen-Chi , Chen Tsai-Yun , Yeh Su-Peng , Wang Ming-Chung , Huang Wen-Tsung , Lee Ming-Yang , Lin Sheng-Fung
Published: March 2022

Background

The incidence of follicular lymphoma (FL) in Taiwan has not been well investigated since its inclusion as a histological subtype in the Taiwan Cancer Registry in 2008. The purpose of this study was to describe the incidence patterns of FL in Taiwan and compare the trends with those in other racial groups in the United States.

Materials and methods

We conducted an epidemiological study using population-based data from the Taiwan Cancer Registry, Ministry of Health and Welfare, and the 18 Surveillance, Epidemiology, and End Results (SEER) registries to evaluate the FL incidence from 2008 to 2017. We calculated the annual percent change (APC) to describe the trends in the incidence of FL in subpopulations defined by race and sex over time.

Results

The annual age-adjusted incidence rate of FL in Taiwan increased significantly from 0.59 per 100,000 persons in 2008 to 0.82 per 100,000 persons in 2017, with an APC of 3.2. By contrast, the incidence rate in whites in the United States during the same period decreased from 3.42 to 2.74 per 100,000 persons, with an APC of −2.1. We found no significant change for the blacks (APC, −1.5%), Hispanics (APC, −0.7%), and Asians or Pacific Islanders (APC, +0.7%). The temporal trend was similar between the males and females. The relative frequency of FL among the incident non-Hodgkin lymphoma (NHL) cases also increased significantly in Taiwan from 7.64% in 2008 to 11.11% in 2017 (APC = 3.8). The relative frequency of FL among the incident NHL cases in the whites decreased from 2008 to 2012 (APC, −3.8%) and then stabilized after 2012 (APC, −0.2%). By contrast, little change in relative frequency of FL among the incident NHL cases was observed in the blacks, Hispanics, and APIs between 2008 and 2017.

Conclusion

We found increases in the incidence of FL and the relative frequency of FL among the incident NHL cases in both males and females in Taiwan from 2008 to 2017. The FL incidence rates were unchanged for all races and sex groups in the United States, except for the decreases in the whites.
Driving the blue fleet: Temporal variability and drivers behind bluebottle (Physalia physalis) beachings off Sydney, Australia
Authors: Bourg Natacha , Schaeffer Amandine , Cetina-Heredia Paulina , Lawes Jasmin C. , Lee Daniel
Published: March 2022

Physalia physalis, the bluebottle in Australia, are colonial siphonophores that live at the surface of the ocean, mainly in tropical and subtropical waters. P. physalis are sometimes present in large swarms, and with tentacles capable of intense stings, they can negatively impact public health and commercial fisheries. P. physalis, which does not swim, is advected by ocean currents and winds acting on its gas-filled sail. While previous studies have attempted to model the drift of P. physalis, little is known about its sources, distribution, and the timing of its arrival to shore. In this study, we present a dataset with four years of daily P. physalis beachings and stings reports at three locations off Sydney’s coast in Australia. We investigate the spatial and temporal variability of P. physalis presence (beachings and stings) in relation to different environmental parameters. This dataset shows a clear seasonal pattern where more P. physalis beachings occur in the Austral summer and less in winter. Cold ocean temperatures do not hinder the presence of P. physalis and the temperature seasonal cycle and that observed in P. physalis presence/absence time-series are out of phase by 3-4 months. We identify wind direction as the major driver of the temporal variability of P. physalis arrival to the shore, both at daily and seasonal time-scales. The differences observed between sites of the occurrence of beaching events is consistent with the geomorphology of the coastline which influences the frequency and direction of favorable wind conditions. We also show that rip currents, a physical mechanism occurring at the scale of the beach, can be a predictor of beaching events. This study is a first step towards understanding the dynamics of P. physalis transport and ultimately being able to predict its arrival to the coast and mitigating the number of people who experience painful stings and require medical help.
Retweet communities reveal the main sources of hate speech
Authors: Evkoski Bojan , Pelicon Andraž , Mozetič Igor , Ljubešić Nikola , Kralj Novak Petra
Published: March 2022

We address a challenging problem of identifying main sources of hate speech on Twitter. On one hand, we carefully annotate a large set of tweets for hate speech, and deploy advanced deep learning to produce high quality hate speech classification models. On the other hand, we create retweet networks, detect communities and monitor their evolution through time. This combined approach is applied to three years of Slovenian Twitter data. We report a number of interesting results. Hate speech is dominated by offensive tweets, related to political and ideological issues. The share of unacceptable tweets is moderately increasing with time, from the initial 20% to 30% by the end of 2020. Unacceptable tweets are retweeted significantly more often than acceptable tweets. About 60% of unacceptable tweets are produced by a single right-wing community of only moderate size. Institutional Twitter accounts and media accounts post significantly less unacceptable tweets than individual accounts. In fact, the main sources of unacceptable tweets are anonymous accounts, and accounts that were suspended or closed during the years 2018–2020.
Geographies of the global co-editor network in oncology
Authors: Csomós György , Lengyel Balázs
Published: March 2022

The co-editor networks of academic journals are generally examined at the journal level. This paper investigates the geographies of the global co-editor network in oncology through the lens of cities. After using different network methods to analyze the global co-editor network, we found that the network can be characterized by a core-periphery structure. The dense core is occupied by many highly interconnected cities, whereas the periphery contains many cities maintaining loose connections with the core cities. The core shows an asymmetric dual sub-core structure. The greater sub-core is constituted by Northern American cities with New York, Washington DC, Boston, Houston, and Los Angeles in the center, whereas the smaller sub-core is formed by Asian cities and centered on Tokyo, Seoul, Osaka, Beijing, and Shanghai. The European core cities do not form a well-outlined sub-core but produce a ringlike shape around the Northern American core. This structure of the co-editor network is a consequence of the prestige effect still characterizing global science. Many European and Chinese journals tend to employ Northern American editors (US-based editors in the first place) to help increase the reputation of the journal. However, US-based journals are more interested in recruiting American editors from the top-ranked national cancer centers and universities rather than outside of the country.
How common are high-risk coronavirus contacts? A video-observational analysis of outdoor public place behavior during the COVID-19 pandemic
Authors: Appelman Joska , Liebst Lasse Suonperä , Lindegaard Marie Rosenkrantz
Published: March 2022

Epidemiological evidence and recommendations from the World Health Organization suggest that close face-to-face interactions pose a particular coronavirus transmission risk. The real-life prevalence and nature of such high-risk contacts are understudied, however. Here, we video-observed high-risk contacts in outdoor public places in Amsterdam, the Netherlands, during the COVID-19 pandemic. We found that high-risk contacts were relatively uncommon: Of the 7,813 individuals observed, only 20 (0.26%) displayed high-risk contacts. Further, we qualitatively examined the 20 high-risk contacts identified and found that they occurred disproportionally between affiliated persons engaged in affiliative behaviors. We discuss the potential public health implications of the relatively low incident rate of high-risk contacts.
Centralidades urbanas: proposta de classificação com base no fluxo de viagens em Belo Horizonte - MG
Authors: Rocha Castilho Luís Otávio , Cardoso Leandro , Lobo Carlos , Kopperschmidt de Oliveira Isabela
Published: March 2022

Os recentes problemas urbanos, notadamente as deficiências em mobilidade urbana e a concentração espacial, apresentam-se como desafios aos pesquisadores e gestores públicos. Neste contexto, quando há o agravamento das distâncias e dos tempos de deslocamentos percorridos pelos citadinos, aponta-se para a fomentação e a manutenção de policentros, desconcentrando equipamentos, serviços e atividades. Tal medida possui potencial para redução das distâncias e dos tempos de deslocamentos, contribuindo, assim, para a melhoria da mobilidade e acessibilidade, bem como da própria qualidade de vida urbana. Essa pesquisa está estruturada para desenvolver e aplicar uma proposta metodológica de classificação de centralidades com base no fluxo de viagens. Ao se utilizar de técnicas de geoprocessamento e medidas de análise espacial, tem como objetivo propor indicadores capazes de classificar as centralidades urbanas, discriminadas em local, regional e municipal. A aplicação para Belo Horizonte - MG, demonstrou que a proposta é viável, tendo sido classificadas 38 centralidades em conformidade com o Plano Diretor, possuindo, assim, capacidade para subsidiar a gestão e elaboração de políticas públicas.
Analisis Rencana Tata Ruang Wilayah Pada Pesisir Rawan Tsunami (Studi Pesisir Aceh, Banten dan Palu)
Authors: Utami Westi
Published: March 2022

Indonesia sebagai negara kepulauan dengan pusat pengembangan perekonomian maupun permukiman berada pada wilayah pesisir memiliki ancaman cukup serius terhadap bencana banjir rob, abrasi, maupun tsunami. Penelitian ini dilakukan untuk mengkaji kebijakan rencana tata ruang yang diterapkan pada daerah-daerah pesisir yakni sebagian Pesisir Aceh, Pesisir Palu dan Pesisir Banten yang memiliki kerawanan bencana tsunami. Metode penelitian dilakukan melalui analisis spasial terhadap kondisi eksisting penggunaan tanah dioverlaykan dengan pola ruang dan tingkat kerawanan bencana. Untuk mengetahui bagaimana kebijakan tata ruang dan manajemen pengelolaan pesisir dilakukan melalui studi literatur dan studi dokumen. Pemetaan penggunaan tanah eksisting di sebagian pesisir Aceh dan Kota Palu diperoleh melalui interpretasi citra Landsat 8, dan untuk pesisir Banten dari interpretasi Foto Udara.  Hasil kajian menunjukkan bahwa revisi RTRW di Kota Banda Aceh belum sepenuhnya mempertimbangkan mitigasi bencana dimana masih terdapat pola ruang permukiman berada pada zona merah rawan tsunami. Begitupun dengan RTRW di Banten dan Kota Palu pola ruang di sekitar pesisir digunakan sebagai permukiman dan pariwisata mengakibatkan tingginya korban jiwa, kerugian dan kerusakan pada tsunami 2018. Hasil kajian menunjukkan bahwa pada 3 wilayah rawan tsunami ini belum sepenuhnya zona merah dijadikan sebagai kawasan lindung/barrier alami perlindungan tsunami. Lemahnya regulasi yang disusun dalam mengendalikan dan memberikan arahan penggunaan tanah yang tepat pada daerah pesisir berdampak terhadap tingginya tingkat risiko yang diakibatkan apabila terjadi bencana. Dalam hal ini maka aspek ekonomi, ancaman bencana, kerentanan, kondisi lingkungan, sosial dan ekosistem serta kehidupan masyarakat hendaknya menjadi bahan pertimbangan dalam pengelolaan wilayah pesisir sehingga ruang yang tersedia mampu mewujudkan kehidupan yang berkelanjutan.
Utilization of ANN technique to estimate the discharge coefficient for trapezoidal weir-gate
Authors: Sahib Jumana Hadi , Al-Waeli Luay Kadhim , Jaber Al Rammahi Ali Hussein
Published: March 2022

Developing and assessing the performance of water projects and irrigation networks is based on many factors, such as flow measurement. Weir and gate structures have been extensively utilized for flow measurement and to get rid of sediments. The process of modeling and estimating the coefficient of discharge in the weir is an essential part of hydraulic engineering. Recently the application of computer skills was adopted instead of traditional methods. In the present study, the artificial neural network (ANN) was adopted to estimate the coefficient of discharge for a combined weir that consisted of the trapezoidal weir and rectangular gate. For this purpose, the experimental data were collected and analyzed. The dimensional analysis was used to identify the effective dimensionless parameters related to the discharge coefficient. The developed ANN network structure was designed as 6-10-1 and adopted the default scaled conjugate gradient algorithm for training using SPSS V24 software. It was found that the proposed model with ten neurons was highly accurate in predicting the discharge coefficient. The sensitivity analysis was adopted to assess the performance of the ANN using different numbers of effective input parameters. Assessing five models, the ratio of upstream head to gate height (H/d), slope of trapezoidal angle (tan θ), and the ratio of distance between weir and gate and gate height (y/d) parameters are adequate for estimating the discharge coefficient compared to other parameters. ANN model with input parameters of H/d, h/d (h is the flow depth over the trapezoidal weir), b
g/d (b
g is the gate width), tan θ, b
g/b (b is the total width of flume), and y/d shows reasonable accuracy with acceptable statistical indicators, coefficient of determination (R
2 = 0.87), relative error (RE = 0.096), and mean squared error (MSE = 1.86) for the discharge coefficient. The ANN model gave a good idea about which factors are more effective on the discharge coefficient, and the process of training the network is more accessible than the traditional method which represent the discharge coefficient by equation.
Development of an eutectic-based self-healing in Al–Si cast alloy
Authors: Kilicli Volkan
Published: March 2022

In this study, a self-healing mechanism was developed by means of melting the eutectic structure for microcrack repair in a hypoeutectic Al–Si cast alloy. The alloy was heated just above the eutectic temperature to provide melting of the eutectic in this mechanism. The melted eutectic Si particles repair the microcrack under appropriate conditions. The microcrack formation was provided by tensile loading in Al–Si alloy tensile bars and then eutectic-based self-healing treatment was performed to ensure microcrack healing. Microcrack healing was monitored by X-ray radiography and microstructural examinations were carried out by scanning electron microscopy. The mechanical properties were investigated by tensile testing before and after the healing treatment. Eutectic-based self-healing treatment provides the healing of some microcracks in the microstructure of hypoeutectic Al–Si cast alloy. Also, 44% of yield strength, 59% of ultimate tensile strength, and 86% of total elongation have been recovered by the eutectic-based self-healing process in Al–Si alloy.
Mechanical properties and corrosion behavior of a friction stir processed magnesium alloy composite AZ31B–SiC
Authors: Lu Yongxin , Li Wangxin , Luo Fan , Feng Hongfeng , Gao Qian , Ma Yuhang , Yang Mingxiao
Published: March 2022

The optimization of friction stir processing (FSP) parameters of magnesium alloy composite (AZ31B–SiC) based on orthogonal test was researched. The results show that the distribution of silicon carbide (SiC) particles, microhardness, tensile property, and fracture mode are greatly affected by the change in process parameters. The results show that the composite was made with a rotating speed of 750 rev·min−1, a traversing speed of 30 mm·min−1, and a processing time of three; the distribution of SiC particles is even, the microhardness difference of composite is small, the tensile property is better, and the ductile fracture is the main fracture mode. Besides, the existence of SiC and the number of FSP have a certain influence on the corrosion performance of the magnesium alloy composite (AZ31B–SiC), and the corrosion resistance of the FSP sample is obviously better than that of the AZ31B magnesium alloy.
Effect of calcination and sintering temperature on porosity and microstructure of porcelain tiles
Authors: Durgun Ramazan , Abalı Serkan
Published: March 2022

Porcelain tiles are prepared from kaolin, silica sand, feldspar, clay raw materials, and various additives. Ceramic powders are calcined at different temperatures after grinding, drying, and sieving. After the powders are formed and dried, they are sintered at different temperatures. Firing shrinkage (FS), water absorption (WA), and three-point flexure tests of the samples are compared. The mineralogical definitions are completed by performing a phase analysis via X-ray diffraction (XRD). After the microstructural investigations, pore-sizes and distributions are examined by the Barrett–Joyner–Halenda (BJH) method. The powder sintering process increases the crystallization of the compact material. Low porosity and high strength structures are obtained for the samples with powder calcination temperatures of 800 and 900 °C and a compact sintering temperature of 1200 °C. The pore volume increases by increasing the powder calcination temperature in samples compact-sintered at 1200 °C. When the powder calcination temperature of these samples is increased to 1000 °C, the flexural strength decreases. Therefore, the powder sintering temperature of 900 °C is the critical value.
Effect of water absorption and hydroxyapatite addition on mechanical and microstructural properties of dental luting cements
Authors: Elibol Cagatay , Atalay Ender Göksen , Sagir Kadir , Hazar Yoruc Afife Binnaz
Published: March 2022

In recent years, dental cements have gained more and more importance due to the increasing clinical expectations. They are used as restorative materials and as materials providing critical functions such as chemical and physical adhesion in restorations and protective lining in the cavity. In this work, the effect of water absorption on the mechanical and microstructural properties of different commercial dental cements is systematically investigated. Furthermore, the effect of addition of biocompatible hydroxyapatite on the mechanical and microstructural properties of the cements is characterized. The results show that Voco Meron containing glass ionomer provides the highest values in water absorption and volume change tests. Ketac Cem Radiopaque (209 HV) containing glass ionomer exhibits the highest hardness increase after immersion for 28 days in water, whereas the highest water uptake value is observed in Adhesor Carbofine cement containing zinc polycarboxylate. The hardness of Adhesor ZincPhospate increases with increasing content of hydroxyapatite, whereas in Ketac Cem Radiopaque, the hardness decreases with increasing content of hydroxyapatite significantly. Test results are verified by microstructural analysis of different types of dental cements using scanning electron microscopy and the effect of particle size/distribution on the properties that are of crucial clinical importance is characterized in detail.
The Original and Short Versions of the Activities-Specific Balance Confidence (ABC) Scale in Community-Dwelling Older Adults: Clinical Implications Based on Scale Agreement, Internal Consistencies, and Associations With Self-Rated Health
Authors: Tiernan Chad , Goldberg Allon
Published: March 2022

Background and Purpose:

Balance confidence assessment in older adults has implications for falls prevention and quality of life. It remains unclear whether the original Activities-specific Balance Confidence Scale (ABC-16) or the shortened 6-item scale (ABC-6) is recommended clinically. This study examined ABC-16 and ABC-6 association and agreement, internal consistencies, and relationships with self-rated health (SRH) in community-dwelling older adults.

Methods:

Secondary analysis of an existing dataset (N = 77) was performed. Scale association and agreement were assessed with a Spearman ρ correlation (r
s), intraclass correlation coefficient, 95% limits of agreement (LoA), and Bland-Altman plot. Cronbach α values were calculated to determine internal consistencies. Separate multiple linear regression models with SRH as the outcome and ABC-6 and ABC-16 scores as primary predictors were estimated and subsequently used to conduct Hotelling t test.

Results and Discussion:

Participants were primarily female (80.5%) with a median age of 68 years living in the metro Detroit area. The ABC-6 and ABC-16 were closely associated [r
s = 0.97, P < .001; intraclass correlation coefficient (2,1) = 0.80] but demonstrated discrepancy (95% LoA range of −3.9 to +18.2; mean difference = 7.2 points in the direction of the ABC-16). Cronbach α values were 0.95 (ABC-16) and 0.89 (ABC-6). Regression model 1 (ABC-6 = primary predictor) explained more of the variance (R
2 = 0.36) in SRH compared with model 2 (ABC-16 = primary predictor; R
2 = 0.29). Hotelling t test [t(74) = 2.4, P = .008] found that the predicted values from the ABC-6 model were significantly more highly correlated with SRH than those from the ABC-16 model.

Conclusions:

Despite a high correlation between the ABC-16 and ABC-6, the 2 scales showed limited agreement and should not be considered interchangeable. Given that the ABC-16 takes longer to administer, does not relate to SRH as strongly, and could have redundant items, the ABC-6 may be preferable to the ABC-16 for balance confidence assessment in older adults living in cold weather, urban, or well-resourced areas.
PENDAMPINGAN PADA MASYARAKAT DALAM PENGEMBANGAN MATA PENCAHARIAN MELALUI PEMBERDAYAAN KOMUNITAS PEMUDA DESA DI DESA LAU KECAMATAN DAWE KABUPATEN KUDUS
Authors: Lestari Eta Yuni , Sunarto Slamet , Wijayanti Tutik
Published: March 2022

Setiap desa pada dasarnya memiliki potensi yang dapat dijadikan sebagai peluang untuk mempercepat pembangunan masyarakat desa. Masing-masing kepala desa hingga kepala daerah memiliki tanggungjawab untuk melaksanakan pembangunan sebagai wujud tugas tambahan dalam melaksanakan prinsip otonomi daerah.   Pemerintah daerah menjadi sala satu landasan perubahan sistem tata pengaturan atau tata pemerintahan (governance system) yang penting dalam sejarah pembangunan politik dan pengelolaan administrasi pemerintah secara nasional. Salah satu permasalahan yang dialami oleh masyarakat desa di desa Lau Kecamatan Dawe Kabupaten Kudus adalah adanya ketimpangan antara satu desa dengan desa yang lain Pemuda di desa Lau sebagian besar bekerja sebagai buruh pabrik rokok bagi kaum perempuan, dan buruh bangunan bagi kaum laki-laki, berbeda dengan masyarakat di desa Colo dimana mata pencaharian lebih beragam.  Maka diperlukan kegiatan pendampingan untuk mengembangkan mata pencaharian bagi masyarakat desa khususnya pemuda desa Lau Kecamatan Dawe Kabupaten Kudus. Permasalahan yang dialami mitra adalah , pertama Masyarakat desa belum memiliki keterampilan lain selain menjadi buruh pabrik maupun buruh bangunan, kedua masyarakat Desa Lau telah memiliki komunitas remaja akan tetapi tidak aktif melakukan kegiatan. Ketiga, Masyarakat Desa Lau jarang sekali mendapatkan pelatihan dari dinas, maupun perguruan tinggi . Ke empat Masyarakat desa Lau belum memiliki kemampuan kewirausahaan. Tahapan kegiatan pengabdian dilaksanakan dengan perencanaan kegiatan, pelaksanaan kegiatan dan evaluasi.
PENINGKATAN KOMPTENSI SINEMATOGRAFI BAGI PELAJAR, MAHASISWA DAN MASYARAKAT UMUM DI KOTA SEMARANG
Authors: Sulistio Basuki , Purwanto Sugeng , Wahzudik Niam , S. Heri Tri Luqman B. , Suripto Suripto , Oktavianto Nanang
Published: March 2022

Film sebagai genre seni adalah produk sinematografi. Film adalah karya cipta seni dan budaya yang merupakan salah-satu media komunikasi massa audio visual. Kreatifitas merupakan ekspresi yang muncul dari diri seseorang yang menghasilkan karya, kebanggaan, dan juga merupakan sesuatu yang dapat dikenang semasa hidup. Kreatifitas tercipta karena niat dan kecintaan pada sesuatu yang dapat dijadikan inspirasi sehingga menghasilkan karya yang dapat dinikmati semua orang. Kemampuan membuat karya sinematografi pada film yang paling modern saat ini sudah menjadi kebutuhan, baik dari yang profesional maupun amatir serta bagi kalangan masyarakat umum. Kemampuan tersebut tidak hanya mengenal kamera secara global, melainkan juga seorang pelajar atau mahasiswa dituntut mampu mengoperasikan kamera, proses pra produksi, produksi dan pasca produksi. Selain itu sebenarnya banyak pelajar, mahasiswa serta masyarakat umum yang masih memiliki pengetahuan minim sekali tentang sinematografi. Padahal kemampuan ini sangat diperlukan dalam usaha pembuatan film. Metode yang akan digunakan untuk mencapai tujuan kegiatan ini dapat diuraikan sebagai berikut: (1) Workshop sinematografi bagi pelajar, mahasiswa dan masyarakat umum. (2) Memberikan pendampingan saat praktik produksi film dalam kegiatan workshop.
Diversifikasi Produk Beras Merah Cendana menjadi Angkak sebagai Produk Kesehatan di Desa Mengesta
Authors: Parwati Ni Nyoman , Ristiati Ni Putu , Atmadja Anantawikrama Tungga
Published: March 2022

Tujuan pelaksanaan program ini adalah menerapkan teknologi untuk menghasilkan versi produk beras merah jenis cendana menjadi produk makanan/minuman kesehatan. Beras merah cendana merupakan produk unggulan desa Mengesta, Penebel, Tabanan. Luaran yang ditargetkan adalah meningkatkan pengetahuan dan keterampilan masyarakat di bidang teknologi pengolahan pangan dan menambah sumber penghasilan masyarakat. Metode pelaksanaan kegiatan menggunakan metode PAP (Participatory Assessment and Planning) yang terdiri dari empat langkah pokok, yaitu: (1) menemukan masalah, (2) menemu kenali potensi, (3) menganalisis masalah dan potensi, dan (4) memilih solusi pemecahan masalah. Data dianalisis secara deskriptif dan kualitatif. Hasil kegiatan ini adalah sebagai berikut. (1) Meningkatnya pengetahuan dan keterampilan masyarakat di bidang teknologi pengolahan pangan dengan memanfaatkan beras merah cendana. (2) Terciptanya produk olahan beras merah menjadi angkak sebagai minuman kesehatan dan penghasil zat pewarna makanan alami, dan (3) Bertambahnya sumber mata pencaharian masyarakat yang berdampak pada adanya peningkatan ekonomi lokal.
Growth hormone therapy in short-stature patients with kyphoscoliosis: a literature review
Authors: Alharbi Mariam S
Published: March 2022

The aim of the study was to conduct a literature review on growth hormone therapy in short-stature patients with kyphoscoliosis.

The search strategy was performed in which all the relevant papers published in 20 years were included on Pub Med, Central, and Google scholar by using keywords short stature, growth hormones, adverse events of growth hormones in kyphoscoliosis, safety.

The study investigation supports the idea that giving human growth hormone (HGH) to a diverse population of short-statured children does not enhance the occurrence of scoliosis.

Patients on HGH therapy for progressing scoliosis had syndromes in which scoliosis was more prevalent in an age-matched group. Short stature attributed to progressive growth failure is prevalent in all mucopolysaccharidosis (MPS) disorders, as per the existing research on growth and growth hormone in MPS.

MPS should be explored in children who are being tested for short stature since growth failure might be the presenting symptom.
Surgical management options for long-bone metastasis
Authors: Cirstoiu Catalin , Cretu Bogdan , Iordache Sergiu , Popa Mihnea , Serban Bogdan , Cursaru Adrian
Published: March 2022

Bone metastases are difficult to treat surgically, necessitating a multidisciplinary approach that must be applied to each patient depending on the specifics of their case.

The main indications for surgical treatment are a lack of response to chemotherapy, radiation therapy, hormone therapy, immunotherapy, and bisphosphonates which is defined by persistent pain or tumor progression; the risk of imminent pathological bone fracture; and surgical treatment for single bone metastases.

An important aspect of choosing the right treatment for these patients is accurately estimating life expectancy. Improved chemotherapy, postoperative radiation therapy, and sustainable reconstructive modalities will increase the patient’s life expectancy.

The surgeon should select the best surgical strategy based on the primary tumor and its characteristics, the presence of single or multiple metastases, age, anatomical location, and the functional resources of the patient.

Preventive osteosynthesis, osteosynthesis to stabilize a fracture, resections, and reconstructions are the main surgical options for bone metastases.

Resection and reconstruction with a modular prosthesis remain the generally approved surgical option to restore functionality, increase the quality of life, and increase life expectancy.

Preoperative embolization is necessary, especially in the case of metastases of renal or thyroid origin. This procedure is extremely important to avoid complications, with a major impact on survival rates.
Prácticas lectoras durante la cuarentena. Una experiencia desde Argentina
Authors: Sánchez María Gabriela
Published: March 2022

Este texto relata las experiencias educativas realizadas durante el ciclo lectivo 2020 en un instituto de formación docente (IFD 11) ubicado en la provincia de Neuquén, República Argentina. Por iniciativa de docentes, directivos y estudiantes de la mencionada institución, bajo el título Había Una Vez, se llevó adelante una propuesta de difusión de material literario mediante redes sociales y radios, donde se compartieron textos pertenecientes a diferentes géneros: libro álbum, poesía, narrativa, microrrelato, teatro y radioteatro. Buscando dar voz a estudiantes de la comunidad, este emprendimiento educativo construyó redes y fue creciendo al compartir las producciones con otras instituciones educativas del país y del extranjero, desde la guía las palabras de Gianni Rodari: “El uso total de la palabra para todos es un bello lema de sentido democrático, no para que todos sean artistas, sino para que nadie sea esclavo
La literatura como instrumento de resistencia y desafío de las estructuras de poder en Centroamérica analizado en las obras de Gerardo Maloney y Quince Duncan
Authors: Smart Ian Isidore
Published: March 2022

Con el análisis de las obras de Gerardo Maloney (1945) y Quince Duncan(1940) se intenta demostrar que constituyen el mejor instrumento de resistencia y desafío de las estructuras de poder en Centroamérica. Primero, establecen las estructuras de poder en el mundo entero, fueron fundadas a fines del siglo XVIII por ideólogos europeos, quienes inventaron la teoría del “modelo ario”.La teoría se basa, en su totalidad, en “hechos alternativos”. Es la base fundamental de la civilización occidental, y consiste en la supremacía blanca. La mentira másperversa proveniente del sistema de datos alternativos del “modelo ario” será que los africanos son los últimos en desarrollar una literatura. El escritor afrodescendiente colombiano Manuel Zapata Olivella (1920-2005) dio el primer paso en crear una literatura de auténtica representación de la gran riqueza cultural de la comunidad afro de habla hispana. Duncan dio el segundo paso, por ponerse en contacto directo con la religión y la filosofía de la comunidad afro de Costa Rica. Maloney en su arte, va directo al grano, celebrando las acciones ya realizadas por los héroes que sirven de modelo para los activistas que se dedican a resistir y desafiar las estructuras de poder y así liberarnos de la esclavitud mental.
El afrorrealismo como insumo teórico para el análisis literario
Authors: Rodríguez-Rojas Paola
Published: March 2022

La obra de Quince Duncan ha sido galardonada con premios nacionales e internacionales, reconociéndole, justamente, el aporte brindado a través de sus cuentos y novelas. No obstante, existe una faceta del autor como crítico, teórico literario y ensayista que no ha sido examinada de manera consistente y detallada, en especial en su propuesta afrorrealista. Dicha corriente ha sido vista de manera simplificada por parte de la crítica literaria, situación que ha impedido el estudio profundo de la literatura afrolatinoamericana. Por lo tanto, se realiza una búsqueda de antecedentes teóricos duncanianos, a fin de conocer las raíces del afrorrealismo, mediante la revisión de textos que tienen su base en el trabajo realizado por el autor a lo largo de su carrera y cuya naturaleza aborda espacios de diversa índole: educativo, legislativo, político y crítica literaria.
RECEPTION OF F. M. DOSTOEVSKY’S NOVEL IN TURKISH LITERATURE OF THE 20TH — 21ST CENTURIES
Authors: Shener Leyla
Published: March 2022

F. M. Dostoevsky is one of the most prominent figures in the history of world culture and literature, whose work has had a strong influence on writers from different countries. The article examines the reception of F. M. Dostoevsky’s creative heritage in Turkish literature of the 20th and 21s centuries. The main translations of his works into Turkish from the 1920s to the present are noted, Turkish translators and researchers who studied the work of the Russian writer are named. The article provides an overview of the works of leading Turkish writers (P. Safa, S. Ali, A. H. Tanpinar, S. Agaoglu, D. Ozlu, V. O. Bener, B. Karasu, O. Atay, R. Ozdenoren, O. Pamuk, L. Tekin, M. Mungan, etc.) that reflect the ideas and images of F. M. Dostoevsky. The influence of his novels on Turkish literature was reflected in the similarity of themes, problems, ideas, motifs, images, narrative style, ways of depicting reality in the works of Turkish writers, especially at the level of artistic insight into tragic life collisions, universal values, human mental life, features and motifs of his behavior, as well as in the development of the novel as a genre. Master’s and doctoral dissertations of Turkish researchers, scientific articles, monographs, publications in journals, interviews with Turkish writers were used as sources of research.
Ecological and coenotic differentiation of meadow vegetation of Buzkyi Gard National Nature Park
Authors:   M.G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Shyriaieva D.V.
Published: March 2022

The diversity of mesic and wet grasslands for the north part of the steppe zone in the Southern Bug River basin is characterized by the example of Buzkyi Gard National Nature Park and adjacent territories. I classified 39 vegetation relevés with quantitative classification methods (JUICE, TWINSPAN modified algorithm) and obtained seven clusters, which represent three associations, three communities and one derivate community within six alliances (Agrostion vinealis, Althaeion officinalis, Arrhenatherion elatioris, Convolvulo arvensis-Agropyrion repentis, Potentillion anserinae, Veronico longifoliae-Lysimachion vulgaris). Using Canonical Correspondence Analysis (CCA), Detrended Correspondence Analysis (DCA) and Didukh’s ecological scales, I determined the main environmental factors, which explain differentiation of the resulted vegetation units: variability of damping, salt regime of a soil, soil moisture, soil aeration, carbonate content in a soil, light. Characterized vegetation corresponds to six habitat types of the EUNIS classification (R21, R22, R35, R36, R55, V38). I also reviewed the major factors of negative impact on the meadow vegetation of the territory, in particular the changes of traditional land use in the last decades and their consequences. The main measures of management for studied communities should be mowing, moderate grazing, and removal of tree and shrub species if necessary.
How the Asian and European Communities Accept Negative Numbers
Authors: Maryati Tita Khalis , Aisah K , Miftah Ramdani
Published: March 2022

AbstractThis research is based on several inquiries from mathematics educators on the origins of negative numbers and their acceptance in the community. This study used library research, or more precisely, bibliographical studies, as a method. The research examined how the Asian and European communities accept negative numbers. The study's findings indicated that the Asian and European communities accept negative numbers differently. In comparison to the Asian population, the European populace takes a long time to accept negative figures. It resulted in numerous contrasts between the Asian and European Communities, one of which is in terms of religiosity. This study established that religiosity has an effect on the Asian and European communities' acceptance of negative numbers.AbstrakPenelitian ini didasarkan pada beberapa pertanyaan dari pendidik matematika tentang asal-usul bilangan negatif dan penerimaannya di masyarakat. Penelitian ini menggunakan metode penelitian kepustakaan atau lebih tepatnya studi kepustakaan. Penelitian tersebut mengkaji bagaimana masyarakat Asia dan Eropa menerima angka negatif. Temuan studi menunjukkan bahwa komunitas Asia dan Eropa menerima angka negatif secara berbeda. Dibandingkan dengan penduduk Asia, penduduk Eropa membutuhkan waktu lama untuk menerima angka negatif. Hal ini mengakibatkan banyak perbedaan antara Komunitas Asia dan Eropa, salah satunya dalam hal religiositas. Studi ini menetapkan bahwa religiusitas berpengaruh pada penerimaan masyarakat Asia dan Eropa terhadap angka negatif. How to Cite: Maryati, T. K., Aisah, K., Miftah, R. (2021). How the Asian and European Communities Accept Negative Numbers. TARBIYA: Journal of Education in Muslim Society, 8(2), 167-178. doi:10.15408/tjems.v8i2.25042.
Changes in molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in the intensive care units of a Greek hospital, 2018–2021
Authors: Zarras Charalampos , Pappa Styliani , Zarras Konstantinos , Karampatakis Theodoros , Vagdatli Eleni , Mouloudi Eleni , Iosifidis Elias , Roilides Emmanuel , Papa Anna
Published: March 2022

The spread of multi-drug resistant (MDR) Gram-negative bacteria, including Klebsiella pneumoniae, constitutes a global threat. The most frequent mechanism of acquired carbapenem resistance is the production of carbapenemases, especially KPC, NDM, VIM, IMP and OXA-48. We analyzed the epidemiological trend of carbapenem resistance genes of carbapenem-resistant K. pneumoniae (CRKP) strains isolated from critically ill patients in a Greek tertiary hospital.

The study included 150 CRKP isolates collected from 116 (77.4%) patients hospitalized in the adult ICU and 17 (11.3%) each in the pediatric and the two neonatal ICUs between March 2018 and March 2021. Identification and antimicrobial susceptibility testing were performed using VITEK-2. A multiplex lateral flow immunoassay was used for the detection of carbapenemases, while the detection of bla
VIM, bla
KPC, bla
NDM, bla
IMP and bla
OXA-48-like genes was achieved by multiplex PCR.

The bla
NDM was mainly detected in adults (54/116, 46.9%), while in children the most often detected gene was bla
KPC (24/34, 70.6%). The predominant carbapenem resistance gene during 2018–2019 was bla
KPC alone or in combination with bla
VIM, reaching 44.4% in 2019, while during 2020–2021 the detection of bla
NDM prevailed significantly, reaching 45.5 and 60.7% for 2020 and 2021, respectively.

A shift in the molecular epidemiology of CRKP was seen during 2018–2021, which is probably associated with the recent excessive empiric use of newer antimicrobials. Surveillance studies and proper and strict implementation of infection control measures are highly needed to decrease the spread of MDR bacteria, including CRKP.
Avaliação das más-oclusões na dentição mista em um município de médio porte da Bahia
Authors: Correia Lopes Maria Luisa , Santana Flávia Carvalho , Cunha de Morais Laila , Pinto Luís Felipe Sant’Ana Bastos , Lima dos Anjos Marina , Santana Naielly Viana , Lima Daniel Ferraz , Ribeiro Patrícia Maria Coelho
Published: March 2022

A má-oclusão pode ser definida como uma alteração do crescimento e desenvolvimento que prejudica o correto posicionamento dos dentes e maxilares. Objetivo: Avaliar a prevalência das má-oclusões em escolares com idade entre 6 e 12 anos em um munícipio de médio porte da Bahia. Material e métodos: Estudo transversal executado na Rede Pública de Ensino. A coleta de dados foi realizada por examinador treinado e calibrado. A análise estatística foi executada por meio do Teste Exato de Fisher. Resultados: Uma amostra de 242 crianças com média de idade de 8 anos (DP=1,3) foi observada. Destas, 12% apresentavam mordida aberta, 8,3% mordida cruzada e 5,4% mordida profunda. Não houve associação estatisticamente significativa entre as variáveis período, idade, má-oclusão e gênero (p0,05). Conclusão: A prevalência de má-oclusão na amostra desta pesquisa foi de 25,7%, havendo a necessidade de estudos complementares para estabelecimento das possíveis causas.
Editorial
Authors: Paganotti Ivan , Vargas Herom
Published: March 2022

O terceiro número do volume 43 da revista Comunicação Sociedade, do Programa de Pós-Graduação em Comunicação Social da Universidade Metodista de São Paulo (PósCom-Umesp) encerra o ano de 2021 com a publicação de pesquisas científicas de pesquisadores de universidades brasileiras e europeias, de modo a permitir que nossa comunidade científica tenha acesso às pesquisas recentes e de impacto em nossa área de estudos comunicacionais.
National Health and Nutrition Examination Survey, 2017–March 2020 Prepandemic File: Sample Design, Estimation, and Analytic Guidelines.
Authors: Akinbam Lara , Chen Te-Ching , Davy Orlando , Ogden Cynthia , Fink Steven , Clark Jason , Riddles Minsun , Mohadjer Leyla
Published: March 2022

This report describes the creation of the NHANES 2017–March 2020 prepandemic data files.