bluuebunny/crossref_metadata_2025 huggingface dataset:
Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3‐L1 cells via activation of AMP‐activated protein kinase
Authors: Park Su‐Jin , Park Jae Ho , Han Anna , Davaatseren Munkhtugs , Kim Hyun Jin , Kim Myung‐Sunny , Hur Haeng Jeon , Sung Mi‐Jeong , Hwang Jin‐Taek , Yang Hye Jeong , Kwon Dae Young
Published: April 2015

The purpose of this study is to investigate the effects of euphorbiasteroid, a component of Euphorbia lathyris L., on adipogenesis of 3T3‐L1 pre‐adipocytes and its underlying mechanisms. Euphorbiasteroid decreased differentiation of 3T3‐L1 cells via reduction of intracellular triglyceride (TG) accumulation at concentrations of 25 and 50 μM. In addition, euphorbiasteroid altered the key regulator proteins of adipogenesis in the early stage of adipocyte differentiation by increasing the phosphorylation of AMP‐activated protein kinase (AMPK) and acetyl‐CoA carboxylase. Subsequently, levels of adipogenic proteins, including fatty acid synthase, peroxisome proliferator‐activated receptor‐γ and CCAAT/enhancer‐binding protein α, were decreased by euphorbiasteroid treatment at the late stage of adipocyte differentiation. The anti‐adipogenic effect of euphorbiasteroid may be derived from inhibition of early stage of adipocyte differentiation. Taken together, euphorbiasteroid inhibits adipogenesis of 3T3‐L1 cells through activation of the AMPK pathway. Therefore, euphorbiasteroid and its source plant, E. lathyris L., could possibly be one of the fascinating anti‐obesity agent. Copyright © 2015 John Wiley & Sons, Ltd.
Exploring Bacterial Heparinase II Activities with Defined Substrates
Authors: Bohlmann Lisa , Chang Chih‐Wei , Beacham Ifor , von Itzstein Mark
Published: April 2015

Bacterial heparinases that cleave heparan sulfate (HS) and heparin are widely used to generate low‐molecular‐weight heparins (LMWHs) and to structurally and functionally characterise heparin and HS biomolecules. We provide novel insights into the substrate specificity of heparinase II from two different bacteria: Pedobacter heparinus (formerly Flavobacterium heparinum) and Bacteroides eggerthii. The activity towards various well‐defined HS oligosaccharides was investigated by 1H NMR spectroscopy; this revealed distinct specificities for the two heparinases. Heparinase II from P. heparinus appears to be more active and displays a broader substrate specificity than B. eggerthii heparinase II. Furthermore, HS di‐ and tetrasaccharides inhibited B. eggerthii heparinase II activity. A better understanding of heparinase substrate specificity will contribute to the production of homogenous LMWHs, provide better characterisation of heparin and HS and assist therapeutic applications.
Obesity and percutaneous coronary intervention outcomes: Beware the extremes
Authors: Hillegass William B. , Brott Brigitta C.
Published: April 2015

Key Points

Observational associations between high body mass index (BMI) and putatively improved outcomes after percutaneous coronary intervention (PCI) have been called the “obesity paradox.”

The present study shows no association between two year PCI outcomes and BMI ranging from 23 to 34 kg/m2.

Under‐represented in this study, the BMI extremes of <23 and >40 kg/m2 are associated with worse outcomes in the broader literature; but require further study including lean body mass index.
Association of embolism and stroke in the catheterization laboratory
Authors: Gilchrist Ian C.
Published: April 2015

Key Points

Strokes continue to be a rare but potentially devastating event during cardiac catheterization

Most strokes are associated with brain imaging patterns consistent with embolic etiologies

Common embolic etiology supports not only the critical importance of catheterization laboratory techniques to minimize activation of thrombosis or embolism, but also point to potential treatment with rapid application of neurovascular brain salvage techniques.
Optimizing endovascular stroke therapy: A primary PCI deja‐vu?
Authors: Cilingiroglu Mehmet , Marmagkiolis Kostas
Published: April 2015

Key Points

The optimal revascularization modality (thromboembolectomy, suction thrombectomy, angioplasty with stenting, and stent retriever thrombectomy) for the cerebral circulation remains to be defined

Catheter‐based therapy of the acute stroke yields better clinical outcomes in patients <65‐year‐old, with a door‐to‐balloon time <4 hr and successful reperfusion TICI ≥ 2.

Considering the significant incidence of acute strokes which are either ineligible for intravenous thrombolytic therapy or present too late, catheter‐based therapies may offer an alternative treatment option.

Interventional cardiologists should play an active role in the development of endovascular stroke therapy in a multi‐disciplinary team approach.
Palladium‐Catalyzed Construction of Heteroatom‐Containing π‐Conjugated Systems by Intramolecular Oxidative CH/CH Coupling Reaction
Authors: Saito Kenta , Chikkade Prasanna Kumara , Kanai Motomu , Kuninobu Yoichiro
Published: April 2015

Synthesis of heteroatom‐containing ladder‐type π‐conjugated molecules was successfully achieved via a palladium‐catalyzed intramolecular oxidative CH/CH cross‐coupling reaction. This reaction provides a variety of π‐conjugated molecules bearing heteroatoms, such as nitrogen, oxygen, phosphorus, and sulfur atoms, and a carbonyl group. The π‐conjugated molecules were synthesized efficiently, even in gram scale, and larger π‐conjugated molecules were also obtained by a double CH/CH cross‐coupling reaction and successive oxidative cycloaromatization.
ChemInform Abstract: Pr3S2Cl2[AsS3]: A Praseodymium(III) Sulfide Chloride Thioarsenate(III) with Double Chains of Condensed [SPr4]10+ Tetrahedra.
Authors: Kang Dong‐Hee , Ledderboge Florian , Kleinke Holger , Schleid Thomas
Published: April 2015

Single crystals of Pr3S2Cl2[AsS3] are obtained by solid state reaction of Pr2S3, PrCl3, As, and S in a molar ratio of 7:4:6:9 (evacuated silica tubes, 850 °C, 7 d) followed by slow cooling (50 °C/d) to room temperature.
ChemInform Abstract: Triangular Ge3 Units in a New Modification of EuGe3.
Authors: Castillo Rodrigo , Baranov Alexey I. , Burkhardt Ulrich , Grin Yuri , Schwarz Ulrich
Published: April 2015

The hexagonal modification hP8 of EuGe3 is obtained by arc‐melting of a stoichiometric mixture of the elements (1% excess of Eu) followed by high‐pressure sintering (multianvil press, 12 GPa, 1100 K, 1 h).
ChemInform Abstract: A Series of Noncentrosymmetric Antimony Sulfides Ln8Sb2S15 (Ln: La, Pr, Nd) — Syntheses, Crystal and Electronic Structures, and NLO Properties.
Authors: Zhao Hua‐Jun , Zhou Liu‐Jiang
Published: April 2015

Ln8Sb2S15 (Ln: La, Pr, Nd) are prepared by heating stoichiometric mixtures of the elements (evacuated silica tubes, 950 °C, 4 d; cooling to 200 °C at a rate of 2.5 °C/h).
ChemInform Abstract: 27Al and 45Sc NMR Spectroscopy on ScT2Al and Sc(T0.5T′0.5)2Al (T:T′: Ni, Pd, Pt, Cu, Ag, Au) Heusler Phases and Superconductivity in Sc(Pd0.5Au0.5)2Al.
Authors: Benndorf Christopher , Niehaus Oliver , Eckert Hellmut , Janka Oliver
Published: April 2015

Intermetallic Heusler compounds of the composition ScT2Al and Sc(T0.5T′0.5)2Al (T,T′: Ni, Pd, Pt, Cu, Ag, Au) are prepared by arc melting of the elements.
ChemInform Abstract: Thermoelectric Properties of Hot‐Pressed Tl9LnTe6 (Ln: La, Ce, Pr, Nd, Sm, Gd, Tb) and Tl10‐xLaxTe6 (0.90 ≤ x ≤ 1.05).
Authors: Guo Quansheng , Kleinke Holger
Published: April 2015

Nearly single phase samples of Tl9LnTe6 (Ln: La, Ce, Pr, Nd, Sm, Gd, Tb) and Tl10‐xLaxTe6 (x = 0.9‐1.1) are prepared by melting of the elements (C‐coated evacuated quartz tubes, 1200 K, 24 h).
ChemInform Abstract: Synthesis and Physical Properties of Cr—P‐Based Intermetallic Compounds: Cr3P, Cr3PC, and Cr3PN.
Authors: Zu L. , Lin S. , Tong P. , Lin J. C. , Kan X. C. , Wang B. S. , Song W. H. , Sun Y. P.
Published: April 2015

Polycrystalline Cr3PX (X: C, N, and vacancy) compounds are prepared by solid state reaction of Cr, P, C, and CrN (evacuated quartz tubes, 1.
ChemInform Abstract: K5Mn3O6 and Rb8Mn5O10, New Charge Ordered Quasi One‐Dimensional Oxomanganates (II, III).
Authors: Nuss Juergen , Dasari Prasad L. V. K. , Jansen Martin
Published: April 2015

K5Mn3O6 (I) and Rb8Mn5O10 (II) are prepared via the azide/nitrate route from stoichiometric mixtures of MnO and KNO3/KN3, or RbNO3/RbN3, resp.
ChemInform Abstract: pH Controlled Pathway and Systematic Hydrothermal Phase Diagram for Elaboration of Synthetic Lead Nickel Selenites.
Authors: Kovrugin Vadim M. , Colmont Marie , Terryn Christine , Colis Silviu , Siidra Oleg I. , Krivovichev Sergey V. , Mentre Olivier
Published: April 2015

The PbO—NiO—SeO2 system is investigated under hydrothermal conditions (Teflon‐lined Parr reaction vessel, 473 K, 36 h).
ChemInform Abstract: A New, Cheap, and Productive FeP Anode Material for Sodium‐Ion Batteries.
Authors: Li Wei‐Jie , Chou Shu‐Lei , Wang Jia‐Zhao , Liu Hua‐Kun , Dou Shi‐Xue
Published: April 2015

FeP is prepared in large quantities by ball milling of stoichiometric mixtures of the elements for 20 h.
ChemInform Abstract: Pentafluoro‐oxotellurate(VI) Anions of Mercury(II); Syntheses and Structures of [Hg(OTeF5)4]2‐, [Hg(OTeF5)5]3‐, [Hg2(OTeF5)6]2‐, [Hg(OTeF5)4] 2‐·Hg(OTeF5)2, and [Hg2(OTeF5)7] 3‐·Hg(OTeF5)2.
Authors: DeBackere John R. , Mercier Helene P. A. , Schrobilgen Gary J.
Published: April 2015

The coordination behavior of (I) toward the [OTeF5]‐ anion is investigated by reactions of (I) with different [OTeF5]‐ salts.
ChemInform Abstract: The Short Series of Lanthanoid(III) Nitride Tellurides with the Composition Ln3NTe3(Ln: Gd‐Ho).
Authors: Foltin Markus L. , Schleid Thomas
Published: April 2015

Ln3NTe3 (Ln: Gd‐Ho) are prepared by solid state reactions of Ln, NaN3, Te, I2 (as Na trap), and NaI as flux (evacuated silica tubes, 950 °C, 7 d).
ChemInform Abstract: About the Syntheses of Chalcogenidometalates by in‐situ Reduction with Elemental Alkali Metals.
Authors: Thiele Guenther , Vondung Lisa , Dehnen Stefanie
Published: April 2015

Phases of nominal composition PbCh·Ch (Ch: chalcogen), Bi2Te3·Te, and Tl2Te·Te are prepared by fusion of the elements in quartz ampoules under Ar prior to their reduction by K in a solution of en and 18‐crown‐6.
ChemInform Abstract: Bi2S3 Bipyramids in Layered Sulfides M2Bi2S3(AlCl4)2 (M: Ag, Cu).
Authors: Groh Matthias F. , Knies Maximilian , Isaeva Anna , Ruck Michael
Published: April 2015

Polycrystalline Cu2Bi2S3(AlCl4)2 (I) and Ag2Bi2S3(AlCl4)2 (II) are prepared by solid state reaction of 2:1:2 molar mixtures of CuCl (AgCl), Bi2S3, and AlCl3 (quartz ampoules, 200 °C, 7 d).
ChemInform Abstract: Synthesis, Crystal Structure, and Properties of Mn(PO3F)(H2O)2.
Authors: Weil Matthias , Baran Enrique J. , Kremer Reinhard K. , Libowitzky Eugen
Published: April 2015

Single crystals of Mn(PO3F)(H2O)2 are grown in a metathesis reaction from aqueous solutions of MnCl2 and (NH4)2(PO3F) (8 °C, 3 d).
ChemInform Abstract: A Catalytic Reactor for the Organocatalyzed Enantioselective Continuous Flow Alkylation of Aldehydes.
Authors: Porta Riccardo , Benaglia Maurizio , Puglisi Alessandra , Mandoli Alessandro , Gualandi Andrea , Cozzi Pier Giorgio
Published: April 2015

A series of chiral alcohols (III), (V), and (VII) is prepared by a reaction of cationic electrophiles with aldehydes in a packed‐bed reactor filled with a polymer‐supported enantiopure imidazolidinone catalyst.
ChemInform Abstract: Asymmetric Synthesis of 3‐Substituted Indole Derivatives Containing Tetrahydrothiophene via Cascade Sulfa‐Michael/Michael Additions Catalyzed by a Chiral Squaramide Catalyst.
Authors: Li Ying‐He , Zhao Bo‐Liang , Gao Yu , Du Da‐Ming
Published: April 2015

The substrate scope of the title reaction is studied.
ChemInform Abstract: Syntheses of Chiral Ferrocenophanes and Their Application to Asymmetric Catalysis.
Authors: Zhang Qiying , Cui Xiuling , Chen Lianmei , Liu Haitao , Wu Yangjie
Published: April 2015

Chiral N‐substituted azaferrocenophanes are prepared and evaluated in the Cu(I)‐catalyzed asymmetric oxidative homocoupling of naphthol derivatives and in the asymmetric Michael addition of nitro olefins to ketones.
ChemInform Abstract: Ruthenium‐Catalyzed Tandem‐Isomerization/Asymmetric Transfer Hydrogenation of Allylic Alcohols.
Authors: Slagbrand Tove , Lundberg Helena , Adolfsson Hans
Published: April 2015

An efficient, Ru‐catalyzed one‐pot procedure for the direct conversion of racemic allylic alcohols to enantiomerically enriched saturated alcohols is presented.
ChemInform Abstract: Fine‐Tuning the Structures of Chiral Diamine Ligands in the Catalytic Asymmetric Aldol Reactions of Trifluoromethyl Aromatic Ketones with Linear Aliphatic Ketones.
Authors: Zong Hua , Huang Huayin , Bian Guangling , Song Ling
Published: April 2015

Primary‐tertiary diamine ligand (PAD) is found to be the most efficient one out of a series of 20 candidates tested.
ChemInform Abstract: Cu‐Catalyzed Intramolecular Hydroarylation of Alkynes.
Authors: Wang Yun‐Long , Zhang Wen‐Man , Dai Jian‐Jun , Feng Yi‐Si , Xu Hua‐Jian
Published: April 2015

A range of 2H‐naphthalene and ‐chromene derivatives are synthesized via efficient Cu‐catalyzed intramolecular hydroarylation reactions of appropriate alkynes.
ChemInform Abstract: Substituent Electronic Effects Govern Direct Intramolecular C—N Cyclization of N‐(Biphenyl)pyridin‐2‐amines Induced by Hypervalent Iodine(III) Reagents.
Authors: Chu Jean‐Ho , Hsu Wen‐Ting , Wu Yi‐Hua , Chiang Meng‐Fan , Hsu Nan‐Hai , Huang Hao‐Ping , Wu Ming‐Jung
Published: April 2015

The direct intramolecular C—N cyclization of N‐(biphenyl)pyridin‐2‐amines in the presence of hypervalent iodine(III) reagents is strongly influenced by substituent electronic effects.
ChemInform Abstract: Chemoselective Intramolecular Wittig Reactions for the Synthesis of Oxazoles and Benzofurans.
Authors: Fan Yu‐Shiou , Das Utpal , Hsiao Ming‐Yu , Liu Meng‐Hsien , Lin Wenwei
Published: April 2015

By appropriate choice of reaction conditions or trapping reagents, the course of the reaction can be controlled towards chemoselective formation of either oxazoles or benzofurans.
ChemInform Abstract: Highly Enantioselective Ring‐Opening Reactions of Aziridines with Indole and Its Application in the Building of C3‐Halogenated Pyrroloindolines.
Authors: Yang Dongxu , Wang Linqing , Han Fengxia , Li Dan , Zhao Depeng , Cao Yiming , Ma Yunxia , Kong Weidong , Sun Quantao , Wang Rui
Published: April 2015

A magnesium‐catalyzed asymmetric ring‐opening reaction of aziridine with indole is realized by employing commercially available chiral ligands.
ChemInform Abstract: Intramolecular N—C Rearrangements Involving Sulfonamide Protecting Groups.
Authors: Saidykhan Amie , Bowen Richard D. , Gallagher Richard T. , Martin William H. C.
Published: April 2015

Amines bearing a sulfonamide and a carbamate protecting group undergo a base mediated rearrangement to form the unexpected products (II) and (IV).
ChemInform Abstract: Light‐Mediated Deoxygenation of Alcohols with a Dimeric Gold Catalyst.
Authors: McCallum Terry , Slavko Ekaterina , Morin Mathieu , Barriault Louis
Published: April 2015

A new protocol for the photolytic bromination of primary alcohols using CBr4 and DMF is developed.
ChemInform Abstract: Heterocycle‐Substituted Tetrazole Ligands for Copper‐Catalyzed Aerobic Oxidation of Alcohols.
Authors: Liu Yangyang , Xie Aming , Li Junjian , Xu Xiao , Dong Wei , Wang Boliang
Published: April 2015

The reaction conditions are not compatible for aliphatic secondary alcohols [e.g. (IIIh)].
ChemInform Abstract: A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins.
Authors: Qu Bo , et al.
Published: April 2015

Several novel air‐stable chiral dihydrobenzooxaphosphole oxazoline ligands are presented and used in Ir‐catalyzed asymmetric hydrogenations yielding the products with high enantio‐ or diastereoselectivity (examples shown; other presented ligands give products with opposite enantio‐ or diastereoselectivity).
ChemInform Abstract: Catalytic, Stereospecific syn‐Dichlorination of Alkenes.
Authors: Cresswell Alexander J. , Eey Stanley T.‐C. , Denmark Scott E.
Published: April 2015

This is the first catalytic syn‐stereospecific dichlorination of alkenes using the redox‐active main group element selenium in a group transfer catalyst.
ChemInform Abstract: Copper and Palladium Mediated C—H Chlorination on 8‐Acylaminoquinoline Scaffolds.
Authors: Guo Haili , Chen Miaomiao , Jiang Peng , Chen Jian , Pan Lingxia , Wang Min , Xie Chunsong , Zhang Yuhong
Published: April 2015

Two reaction systems are evaluated toward the efficient site‐selective mono‐ or dichlorination of substituted 8‐acylaminoquinolines.
ChemInform Abstract: Zeo‐Click Synthesis: Copper‐Zeolite‐Catalyzed Synthesis of Ynamides.
Authors: Harkat Hassina , Borghese Sophie , De Nigris Matteo , Kiselev Serguei , Beneteau Valerie , Pale Patrick
Published: April 2015

Copper(I)‐ultra stable Y zeolite (USY) is found to be a very efficient heterogeneous catalyst for coupling of functionalized 1‐bromoalkynes and various nitrogen derivatives.
ChemInform Abstract: Photoredox Catalysis in a Complex Pharmaceutical Setting: Toward the Preparation of JAK2 Inhibitor LY2784544.
Authors: Douglas James J. , Cole Kevin P. , Stephenson Corey R. J.
Published: April 2015

Key step in the preparation of title compound (Ib) is the direct photochemical aminomethylation of building block (II).
ChemInform Abstract: Efficient Cross‐Coupling of Dioxazaborocanes with α‐Phosphate Enamides.
Authors: Gigant Nicolas , Honraedt Aurelien , Gras Emmanuel , Gillaizeau Isabelle
Published: April 2015

Nonaromatic α‐phosphate enamides react with heteroaromatic dioxazaborocanes to afford α‐functionalized enamides in high yields via palladium‐catalyzed cross‐coupling reactions.
ChemInform Abstract: Aryl Imidazylates and Aryl Sulfates as Electrophiles in Metal‐Free ArSN1 Reactions.
Authors: Qrareya Hisham , Protti Stefano , Fagnoni Maurizio
Published: April 2015

2,2,2‐Trifluoroethoxy aryl sulfates, formed in situ from imidazolium salts (I), represent a new class of photoactive substrates capable of generating aryl cations which can be trapped by various nucleophiles.
ChemInform Abstract: Highly Linear Selective Cobalt‐Catalyzed Addition of Aryl Imines to Styrenes: Reversing Intrinsic Regioselectivity by Ligand Elaboration.
Authors: Xu Wengang , Yoshikai Naohiko
Published: April 2015

Using a cobalt‐based catalytic system with bis(2,4‐dimethoxyphenyl)(phenyl)phosphine as ligand and either 2‐methoxypyridine or DBU as Lewis base additive, a highly linear selective, imine‐directed hydroarylation of styrene is achieved.
ChemInform Abstract: N‐Boc Deprotection and Isolation Method for Water‐Soluble Zwitterionic Compounds.
Authors: Liu Zhijian , Yasuda Nobuyoshi , Simeone Michael , Reamer Robert A.
Published: April 2015

An efficient iodotrimethylsilane‐mediated deprotection and direct isolation method to obtain zwitterionic compounds from the corresponding N‐Boc derivatives is developed.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Reactions of 1‐Bromo‐2‐fluorobenzenes with Various Nucleophiles: Effective Combination of Carbonylation and Nucleophilic Substitution.
Authors: Chen Jianbin , Natte Kishore , Neumann Helfried , Wu Xiao‐Feng
Published: April 2015

A systematic study on the carbonylative transformation of 1‐bromo‐2‐fluorobenzenes with various nucleophiles is performed.
ChemInform Abstract: A Palladium Nanoparticle—Nanomicelle Combination for the Stereoselective Semihydrogenation of Alkynes in Water at Room Temperature.
Authors: Slack Eric D. , Gabriel Christopher M. , Lipshutz Bruce H.
Published: April 2015

Pd nanoparticles are generated prior to addition of the alkynes from Pd(OAc)2 and NaBH4.
ChemInform Abstract: Formal [4 + 1] Cycloaddition of Methylenecyclopropanes with 7‐Aryl‐1,3,5‐cycloheptatrienes by Triple Gold(I) Catalysis.
Authors: Wang Yahui , Muratore Michael E. , Rong Zhouting , Echavarren Antonio M.
Published: April 2015

7‐Aryl‐1,3,5‐cycloheptatrienes and methylenecyclopropanes react in a triple gold(I)‐catalyzed transformation to cyclopentenes.
ChemInform Abstract: Diastereoselective Synthesis of 2‐Arylmethylene‐6‐hydroxyspiro[4.5]deca‐7‐ones via FeCl3·6H2O‐Catalyzed Spiroannulation/Hydride Transfer of 6‐(5‐Arylpent‐4‐yn‐1‐yl)‐7‐oxabicyclo[4.1.0]heptan‐2‐ols.
Authors: Lin Hsin‐Hui , Lee Kuan‐Yi , Chen Yin‐An , Liu Chi‐Fan , Yeh Ming‐Chang P.
Published: April 2015

The presented spirocyclization is limited to the given diastereomer (I); the corresponding (1R*,2S*,6S*)‐isomer does not react.
ChemInform Abstract: Transition‐Metal‐Catalyzed Synthesis of 1,3‐Diynes and Ynamides from 2‐Bromo‐1‐iodoalkenes.
Authors: Xue Jun , Luo Miao‐Ting , Wen Yue‐Lu , Ye Min , Liu Liang‐Xian , Chen Zheng‐Wang
Published: April 2015

The reaction tolerates aryl and alkyl substituted substrates.
ChemInform Abstract: Trifluoromethoxylation of Arenes: Synthesis of ortho‐Trifluoromethoxylated Aniline Derivatives by OCF3 Migration.
Authors: Hojczyk Katarzyna N. , Feng Pengju , Zhan Chengbo , Ngai Ming‐Yu
Published: April 2015

N‐protected N‐arylhydroxylamines are initially O‐trifluoromethylated prior to a thermally induced migration of the CF3‐O‐group from the amino function to the ortho‐position of the attached arene.
ChemInform Abstract: Highly Stereoselective Synthesis of 2‐Aminobenzylidene Derivatives by a Convergent 3‐Component Approach.
Authors: Xu Zian , Ge Jingying , Wang Tianchi , Luo Ting , Liu Hongwei , Yu Xinhong
Published: April 2015

Deactivated benzaldehydes (I) and (X) react with cyanoacetic amides (II) and esters (VII) and cyclic amines (III) and (V) to the title compounds in moderate to good yields.
ChemInform Abstract: Synthesis of Bromohydrins Using NBS in Presence of Iodine as Catalyst.
Authors: Lodh Raj Sekhar , Borah Arun Jyoti , Phukan Prodeep
Published: April 2015

The advantages of the introduced methodology are mild reaction conditions, cleaner reaction profile, operational simplicity and cheap, non‐toxic and readily available catalyst.
ChemInform Abstract: Multicomponent versus Domino Reactions: One‐Pot Free‐Radical Synthesis of β‐Amino‐Ethers and β‐Amino‐Alcohols.
Authors: Rossi Bianca , Pastori Nadia , Prosperini Simona , Punta Carlo
Published: April 2015

Quaternary β‐amino‐ethers and ‐alcohols are synthesized by optimized one‐pot, three‐component reaction of aryl amines, ketones, and ethers or alcohols mediated by a TiCl4/Zn/tBuOOH system.
ChemInform Abstract: Palladium‐Catalyzed Regioselective ortho‐Acylation of Azoxybenzenes with Aldehyde Derivatives.
Authors: Sun Meng , Hou Le‐Kai , Chen Xiang‐Xiang , Yang Xiao‐Juan , Sun Wei , Zang Yu‐Shi
Published: April 2015

An efficient strategy for the regioselective ortho‐acylation of azoxybenzenes with various aldehydes in the presence of palladium catalysts is developed and furnishes good to excellent yields.
ChemInform Abstract: Metal‐Free in situ sp3, sp2, and sp C—H Functionalization and Oxidative Cross Coupling with Benzamidines Hydrochloride: A Promising Approach for the Synthesis of α‐Ketoimides.
Authors: Kalmode Hanuman P. , Vadagaonkar Kamlesh S. , Chaskar Atul C.
Published: April 2015

A novel, metal‐free protocol for the synthesis of α‐ketoimides (III) via C—H bond functionalization of ethylarenes (I), styrenes (IV) and ethynylarenes (V) followed by oxidative coupling with benzamidine hydrochlorides is developed.
ChemInform Abstract: NbCl5‐Mediated Amidation of Olefins with Nitriles to Secondary Amides.
Authors: Yasuda Kaoru , Obora Yasushi
Published: April 2015

A wide range of aliphatic, aromatic, and cyclic olefins, and aliphatic and aromatic nitriles are used.
ChemInform Abstract: [(IPent)PdCl2(morpholine)]: A Readily Activated Precatalyst for Room‐Temperature, Additive‐Free Carbon‐Sulfur Coupling.
Authors: Farmer Jennifer L. , Pompeo Matthew , Lough Alan J. , Organ Michael G.
Published: April 2015

A series of new, easily activated NHC—PdII precatalysts featuring a trans‐oriented morpholine ligand are prepared and evaluated for activity in carbon‐sulfur cross‐coupling chemistry.
ChemInform Abstract: Symmetric Urea‐Catalyzed Asymmetric Michael Addition of Thiols to β‐Nitrostyrenes.
Authors: Kawazoe Souichirou , Yoshida Kazuki , Shimazaki Yuichi , Oriyama Takeshi
Published: April 2015

The applied catalyst is prepared in one step.
ChemInform Abstract: Iron‐Catalyzed S‐Arylation of Benzothiazole with Aryl Iodides under Aqueous Medium: Facile Synthesis of Aryl(2‐aminoaryl) Sulfides.
Authors: Lee Hang Wai , Yung Ka Fu , Kwong Fuk
Published: April 2015

This simple protocol for facile preparation of aryl(2‐aminophenyl) sulfides involves an inexpensive, air‐stable, and green reaction system.
ChemInform Abstract: Three‐Component Reaction Between Isocyanides, Aliphatic Amines and Elemental Sulfur: Preparation of Thioureas under Mild Conditions with Complete Atom Economy.
Authors: Nguyen Thanh Binh , Ermolenko Ludmila , Al‐Mourabit Ali
Published: April 2015

The presented reaction tolerates a variety of functional groups including aminobenzylamines, which react chemoselectively on the aliphatic amino group.
ChemInform Abstract: Direct and Facile Synthesis of Acyl Isothiocyanates from Carboxylic Acids Using Trichloroisocyanuric Acid/Triphenylphosphine System.
Authors: Entezari Najmeh , Akhlaghinia Batool , Rouhi‐Saadabad Hamed
Published: April 2015

The excellent yields, short reaction times, and mild reaction conditions make this procedure an useful and attractive alternative to the currently available methods.
ChemInform Abstract: Palladium‐Catalyzed Direct C—H Functionalization of Benzoquinone.
Authors: Walker Sarah E. , Jordan‐Hore James A. , Johnson David G. , Macgregor Stuart A. , Lee Ai‐Lan
Published: April 2015

Pd(Tfa)2‐catalyzed arylation, heteroarylation and cycloalkylation of benzoquinone is performed in water as well as in acetone.
ChemInform Abstract: Palladium Supported on Oleic Acid‐coated Magnetic Nanoparticle as an Efficient Catalyst for Heck Coupling Reaction in Aqueous Media.
Authors: Rafiee Ezzat , Ataei Ali , Joshaghani Mohammad
Published: April 2015

The catalyst can be easily recovered by external magnetic field and reused several times without significant loss of activity.
ChemInform Abstract: Methylhydrazine‐Induced Enantioselective α‐Hydroxylation of β‐Keto Esters with Molecular Oxygen Catalyzed by Hydroquinine.
Authors: Wang Yakun , Xiong Ting , Meng Qingwei
Published: April 2015

The environmentally friendly procedure is scalable and allows the recycling of the catalyst which is reused without loss of its activity.
ChemInform Abstract: Chiral Squaramide‐Catalyzed Sulfa‐Michael/Aldol Cascade for the Asymmetric Synthesis of Spirocyclic Tetrahydrothiophene Chromanone Derivatives.
Authors: Zhao Bo‐Liang , Liu Lei , Du Da‐Ming
Published: April 2015

A stereoselective construction of chiral spirocycles, possessing three contiguous stereocenters, in a single operation is achieved in the presence of a bifunctional squaramide catalyst with low catalyst loading.
ChemInform Abstract: Palladium(II)‐Catalyzed Oxidative Dearomatization of Free Naphthols with Two Alkyne Units.
Authors: Gu Songlin , Luo Lei , Liu Jingjing , Bai Lu , Zheng Huayu , Wang Yaoyu , Luan Xinjun
Published: April 2015

The novel [2+2+1] spiroannulation reaction of naphthols with alkynes succeeds using symmetrical diaryl and dialkyl alkynes.Mixed aryl‐alkyl alkynes provide three regioisomeric products one of which is formed with moderate to good excess (not shown).
ChemInform Abstract: Catalytic Asymmetric Construction of Azabicyclo[2.2.1]heptanes Bearing Two Quaternary Stereogenic Centers via Silver(I)‐Catalyzed 1,3‐Dipolar Cycloaddition of Cyclic Azomethine Ylides.
Authors: Xue Zhi‐Yong , Xiong Yong , Wang Chun‐Jiang
Published: April 2015

This novel silver‐catalyzed cycloaddition provides a facile access to bridged azabicycloheptanes.
ChemInform Abstract: Synthesis of 2,3‐Di‐ and 2,2,3‐Trisubstituted‐3‐methoxycarbonyl‐γ‐butyrolactones as Potent Antitumor Agents.
Authors: Le Floch Camille , Le Gall Erwan , Sengmany Stephane , Renevret Patrice , Leonel Eric , Martens Thierry , Cresteil Thierry
Published: April 2015

A variety of the title γ‐butyrolactones (IV) (39 examples) are synthesized by Co‐catalyzed three‐component reaction of itaconate (I) with carbonyl compounds and aryl bromides.
ChemInform Abstract: Ruthenium‐Porphyrin‐Catalyzed Diastereoselective Intramolecular Alkyl Carbene Insertion into C—H Bonds of Alkyl Diazomethanes Generated in situ from N‐Tosylhydrazones.
Authors: Reddy Annapureddy Rajasekar , Zhou Cong‐Ying , Guo Zhen , Wei Jinhu , Che Chi‐Ming
Published: April 2015

Alkyl diazomethanes generated in situ from N‐tosylhydrazones are an effective carbene source for ruthenium‐porphyrin‐catalyzed intramolecular C(sp3)—H bond insertion to give a variety of substituted tetrahydrofurans and pyrrolidines.
ChemInform Abstract: A Simple Synthesis of Alkyl 2‐Aminobenzo[b]thiophene‐3‐carboxylates via an Unexpected Dehydrogenation of Alkyl 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carboxylates.
Authors: Adib Mehdi , Bayanati Maryam , Soheilizad Mehdi , Ghazvini Helia Janatian , Tajbakhsh Mahmood , Amanlou Massoud
Published: April 2015

Methyl cyanoacetate as reaction partner gives slightly lower yields.
ChemInform Abstract: Switchable Stereocontrolled Divergent Synthesis Induced by aza‐Michael Addition of Deactivated Primary Amines under Acid Catalysis.
Authors: Amara Z. , Drege E. , Troufflard C. , Retailleau P. , Huu‐Dau M.‐E. Tran , Joseph D.
Published: April 2015

Conjugate addition of deactivated anilines triggers chemo‐ and stereo‐divergent ring‐closure reaction pathways with a striking selectivity depending on reaction conditions.
ChemInform Abstract: Asymmetric Synthesis of 2‐Substituted Cyclic Amines.
Authors: Kudale Amit A. , Anaspure Prasad , Goswami Falguni , Voss Matthew
Published: April 2015

The synthesis of optically active cyclic amines is based on ring closing reaction of aminoalcohols using the Tsunoda reagent.
ChemInform Abstract: Acylation of Pyrroles and Their Free (N—H)‐Derivatives via Palladium‐Catalyzed Carbopalladation of Nitriles.
Authors: Jafarpour Farnaz , Hazrati Hamideh , Darvishmolla Masoumeh
Published: April 2015

The Pd‐catalyzed reaction of pyrrole (VI) and N‐alkylated pyrroles (I) and (IV) with benzyl‐ and arylnitriles (II) gives the 2‐acylated pyrroles (III), (V), and (VII) regioselectively.
ChemInform Abstract: Palladium‐Catalyzed Direct Desulfitative Arylation of Pyrroles Using Benzenesulfonyl Chlorides as Alternative Coupling Partners.
Authors: Jin Rongwei , Yuan Kedong , Chatelain Emmanuelle , Soule Jean‐Francois , Doucet Henri
Published: April 2015

The reactivity of pyrrole derivatives for palladium‐catalyzed desulfitative arylation is investigated.
ChemInform Abstract: Efficient Diastereo‐ and Enantioselective Synthesis of exo‐Nitroprolinates by 1,3‐Dipolar Cycloadditions Catalyzed by Chiral Phosphoramidite·Silver(I) Complexes.
Authors: Castello Luis M. , Najera Carmen , Sansano Jose M. , Larranaga Olatz , de Cozar Abel , Cossio Fernando P.
Published: April 2015

Chiral complexes formed by privileged phosphoramidites and silver triflate or silver benzoate are excellent catalysts for the general 1,3‐dipolar cycloaddition between azomethine ylides generated from alpha‐amino acid‐derived imino esters and nitroalkenes affording the exo‐cycloadducts (4,5‐trans‐2,5‐cis‐4‐nitroprolinates) with high diastereo‐ and enantioselectivity at room temperature.
ChemInform Abstract: Metal‐Free Regioselective β‐Alkylation of Pyrroles with Carbonyl Compounds and Hydrosilanes: Use of a Broensted Acid as a Catalyst.
Authors: Nomiyama Shota , Tsuchimoto Teruhisa
Published: April 2015

The Broensted acid NHTf2 is found to catalyze the reductive β‐alkylation of pyrroles with carbonyl compounds and hydrosilanes.
ChemInform Abstract: Synthetic Strategies for the Synthesis and Transformation of Substituted Pyrrolinones as Advanced Intermediates for Rhazinilam Analogues.
Authors: Kholod Inga , Vallat Olivier , Buciumas Ana‐Maria , Neels Antonia , Neier Reinhard
Published: April 2015

Studies on the preparation of pyrrolinone‐based analogs of rhazinilam (VII) are presented, using suitably functionalized pyrrolinones, e.g. (VI), as key building blocks.
ChemInform Abstract: One‐Pot Synthesis of 2,5‐Dihydropyrroles from Terminal Alkynes, Azides, and Propargylic Alcohols by Relay Actions of Copper, Rhodium, and Gold.
Authors: Miura Tomoya , Tanaka Takamasa , Matsumoto Kohei , Murakami Masahiro
Published: April 2015

Relay actions of copper, rhodium, and gold formulate a one‐pot multistep pathway, which directly gives 2,5‐dihydropyrroles starting from terminal alkynes, sulfonyl azides, and propargylic alcohols.
ChemInform Abstract: Eco‐Efficient, Chemoselective, and Rapid Access to Aminals from Lactams Using Recyclable Silica‐Supported FeCl3 Catalyst in Green Solvent.
Authors: Ramachandran Gunasekar , Mandlimath Triveni Rajashekhar , Sathesh Venkatesan , Umamahesh Balijapalli , Sathiyanarayanan Kulathu I.
Published: April 2015

The applied catalyst can be removed by easy filtration and dried under vacuum after washing with ethyl acetate before reuse.
ChemInform Abstract: Enantioselective Friedel—Crafts Alkylation of Pyrrole with Chalcones Catalyzed by a Dinuclear Zinc Catalyst.
Authors: Hua Yuan‐Zhao , Han Xing‐Wang , Yang Xiao‐Chao , Song Xixi , Wang Min‐Can , Chang Jun‐Biao
Published: April 2015

A novel chiral azetidine‐based ligand is synthesized and applied to a highly enantioselective Friedel—Crafts alkylation of pyrrole.
ChemInform Abstract: Expedient One‐Pot Synthesis of Pyrroles from Ketones, Hydroxylamine, and 1,2‐Dichloroethane.
Authors: Trofimov Boris A. , Mikhaleva Al'bina I. , Ivanov Andrei V. , Shcherbakova Viktoria S. , Ushakov Igor' A.
Published: April 2015

The reaction provides an access to alkyl, aryl, and hetaryl 2‐substituted and 2,3‐disubstituted pyrroles.
ChemInform Abstract: Rhodium‐Catalyzed Coupling of α‐Lactams with Indole Derivatives.
Authors: Box Hannah K. , Upul Kumarasinghe K. G. , Nareddy Radhika R. , Akurathi Gopalakrishna , Chakraborty Amarraj , Raji Babatunde , Rowland Gerald B.
Published: April 2015

The formation of a C—N bond between the C—3 carbon of α‐lactams and the nitrogen atom of indoles in only 25 minutes is reported.
ChemInform Abstract: Organocatalytic Asymmetric Arylative Dearomatization of 2,3‐Disubstituted Indoles Enabled by Tandem Reactions.
Authors: Zhang Yu‐Chen , Zhao Jia‐Jia , Jiang Fei , Sun Si‐Bing , Shi Feng
Published: April 2015

Arylative dearomatization of indoles in presence of chiral BINOL‐derived phosphate TBP gives 3‐aryl‐3H‐indoles with quaternary stereocenters in high yields with excellent enantioselectivities.
ChemInform Abstract: Tunable Broensted Acidity‐Dependent Alkylation and Alkenylation of Indoles.
Authors: Wu Kaikai , Wu Ping , Wang Liandi , Chen Jiping , Sun Chenglin , Yu Zhengkun
Published: April 2015

The Broensted acid‐mediated alkylation and alkenylation of indoles are efficiently achieved by means of 3‐(dimethylamino)acrylonitrile.
ChemInform Abstract: A Cu‐Catalyzed Synthesis of Substituted 3‐Methyleneisoindolin‐1‐one.
Authors: Gogoi Anupal , Guin Srimanta , Rout Saroj K. , Majji Ganesh , Patel Bhisma K.
Published: April 2015

While reactions of 2‐iodobenzamides (IV) proceeds without a ligand, for 2‐bromo substrates (I), the assistance of a ligand is essential.
ChemInform Abstract: An Unexpected Catalytic Synthesis of Novel and Known Bis(pyrazolyl) Methanes by the Use of α‐Aryl‐N‐phenyl Nitrones in Aqueous Media.
Authors: Eskandari Khalil , Karami Bahador , Khodabakhshi Saeed
Published: April 2015

Reaction of a wide range of nitrones (I) with pyrazolin‐5‐one (II) using silicotungstic acid as catalyst gives unexpectedly bis(pyrazolyl)methanes (III) instead of expected addition products.
ChemInform Abstract: Cellulose Sulfuric Acid as a Bio‐Supported and Efficient Solid Acid Catalyst for Synthesis of Pyrazoles in Aqueous Medium.
Authors: Nasseri Mohammad Ali , Salimi Mehri , Esmaeili Abbas Ali
Published: April 2015

Cellulose sulfuric acid efficiently catalyzes the coupling reaction of 1,3‐dicarbonyl compounds with hydrazine and hydrazide derivatives furnishing pyrazole derivatives in good to excellent yields.
ChemInform Abstract: Sustainable Synthesis of Thioimidazoles via Carbohydrate‐Based Multicomponent Reactions.
Authors: Baumann Marcus , Baxendale Ian R.
Published: April 2015

The simple and high yielding multicomponent reaction is performed on a multigram scale and tolerates a wide range of benzylic amines or aliphatic amines as well as chiral amino acid derived amines.
ChemInform Abstract: FeCl3/ZnI2‐Catalyzed Synthesis of Benzo[d]imidazo[2,1‐b]thiazole Through Aerobic Oxidative Cyclization Between 2‐Aminobenzothiazole and Ketone.
Authors: Mishra Subhajit , Monir Kamarul , Mitra Shubhanjan , Hajra Alakananda
Published: April 2015

The method tolerates a variety of functional groups and is applicable to a wide range of readily accessible ketones.
ChemInform Abstract: A Short and Efficient Protocol for the Synthesis of Imidazo[1,5‐a]quinoxalin‐4‐ones from 3‐Aroylquinoxalinones and Compounds with the Aminomethylene Moiety.
Authors: Mamedov Vakhid A. , Kalinin Aleksey A. , Zhukova Nataliya A. , Syakaev Victor V. , Rizvanov Il'dar Kh. , Latypov Shamil K. , Sinyashin Oleg G.
Published: April 2015

Besides amino acids, which react under through decarboxylation, alkyl amines, diamines, and aminoalcohols serve as aminomethylene sources.
ChemInform Abstract: Copper‐Catalyzed Synthesis of 2‐Arylbenzoxazoles from O‐Aminophenol Derivatives with Arylmethyl Chlorides.
Authors: Zhang Guodong , Wang Peng , Yang Fan , Wu Yangjie
Published: April 2015

In addition to the preparation of 2‐arylbenzoxazoles, the method is applicable to the synthesis of 2‐arylbenzothiazoles and 2‐arylbenzimidazoles (VII).
ChemInform Abstract: Synthesis of Some Novel Class of Bisisoxazolidine Derivatives via 1,3‐Dipolar Cycloaddition Reactions in Water.
Authors: Chakraborty Bhaskar , Luitel Govinda Prasad
Published: April 2015

All the novel bisisoxazolidine derivatives (III), and (V) are very effective against both gram positive and gram negative organisms.
ChemInform Abstract: Multipathways for the Synthesis of Fused Bicyclic 2‐Aminothiazolyl Compounds Tuned by Ring Size.
Authors: Liu Pengfei , Shen Hongfeng , Shao Xusheng , Li Zhong , Xu Xiaoyong
Published: April 2015

A novel and practical protocol for the synthesis of fused bicyclic title compounds from thioureas and epoxycycloketones is presented.
ChemInform Abstract: Elemental Sulfur Disproportionation in the Redox Condensation Reaction Between o‐Halonitrobenzenes and Benzylamines.
Authors: Nguyen Thanh Binh , Ermolenko Ludmila , Retailleau Pascal , Al‐Mourabit Ali
Published: April 2015

The reaction is applied in the synthesis of antitumor agent PMX 610 (IX).
ChemInform Abstract: Control of Regioselectivity over Gold Nanocrystals of Different Surfaces for the Synthesis of 1,4‐Disubstituted Triazole Through the Click Reaction.
Authors: Rej Sourav , Chanda Kaushik , Chiu Chun‐Ya , Huang Michael H.
Published: April 2015

Complete regioselectivity for formation of 1,4‐triazoles is obtained using gold rhombic dodecahedra.
ChemInform Abstract: Acid‐Mediated Synthesis of Fully Substituted 1,2,3‐Triazoles: Multicomponent Coupling Reactions, Mechanistic Study, Synthesis of Serine Hydrolase Inhibitor and Its Derivatives.
Authors: Zhang Huan , Tanimoto Hiroki , Morimoto Tsumoru , Nishiyama Yasuhiro , Kakiuchi Kiyomi
Published: April 2015

Some results indicate that the reaction proceeds through methylenetriazolium intermediates.
ChemInform Abstract: Synthesis of β‐Hydroxy‐1,4‐disubstituted‐1,2,3‐triazoles Catalyzed by Copper Ferrite Nanoparticles in Tap Water Using Click Chemistry.
Authors: Anil Kumar B. S. P. , Harsha Vardhan Reddy K. , Satish G. , Uday Kumar R. , Nageswar Y. V. D.
Published: April 2015

The employed catalyst can be easily separated by using an external magnet.
ChemInform Abstract: Microwave Assisted Synthesis of 1,3,4‐Oxadiazole/Thiohydantoin Hybrid Derivatives via Dehydrative Cyclization of Semicarbazide.
Authors: Yang Seung‐Ju , Lee Jae‐Min , Lee Gee‐Hyung , Kim Na Yeon , Kim Yong‐Sang , Gong Young‐Dae
Published: April 2015

A library of hybrid derivatives containing both 1,3,4‐oxadiazole and thiohydantoin (VIII) (58 examples) is synthesized via microwave‐assisted dehydrative cyclization of semicarbazides possessing a thiohydantoin moiety at one of the acyl termini.
ChemInform Abstract: Synthesis of 5,6‐Dihydropyran‐2‐one Derivatives under Coupled Ultrasonication and Phase Transfer Catalyzed in situ Generated Ketene with Chalcones.
Authors: Gupta Ragini , Jain Anshu , Varshney Bindu
Published: April 2015

Ultrasound‐mediated hetero Diels—Alder reaction of chalcones (II) with ketenes, generated in situ from acetyl chlorides (I) under phase‐transfer catalysis conditions, results in the efficient formation of dihydropyranones (III).
ChemInform Abstract: Anchoring of Ruthenium onto Imine‐Functionalized Zeolite Beta: An Efficient Route for the Synthesis of 4H‐Benzo[b]pyrans and Pyrano[c]chromenes.
Authors: Tabatabaeian Khalil , Zanjanchi Mohammad Ali , Mamaghani Manouchehr , Dadashi Ali
Published: April 2015

The catalyst is recyclable and reusable at least 4 times.
ChemInform Abstract: One‐Pot Multicomponent Synthesis of Indole Incorporated Thiazolylcoumarins and Their Antibacterial, Anticancer and DNA Cleavage Studies.
Authors: Gali Rajitha , Banothu Janardhan , Gondru Ramesh , Bavantula Rajitha , Velivela Yashodhara , Crooks Peter A.
Published: April 2015

All seventeen new compounds (structure examples (IV)) possess promising activity against the screened bacterial strains.
ChemInform Abstract: A Complete Switch of the Directional Selectivity in the Annulation of 2‐Hydroxybenzaldehydes with Alkynes.
Authors: Zeng Huiying , Li Chao‐Jun
Published: April 2015

Rhodium catalysis switches the annulation outcome of salicylaldehydes and arylethyne from isoflavone to coumarin skeleton.
ChemInform Abstract: Application of Nanosized Cu0.5Co0.5Fe2O4 Spinel Ferrite as a Nanocatalyst in the Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthene Derivatives under Solvent‐Free Conditions.
Authors: Fareghi‐Alamdari Reza , Golestanzadeh Mohsen , Zekri Negar
Published: April 2015

The catalyst is found to be reusable several times without significant loss of activity.
ChemInform Abstract: Stereocontrolled Construction of the 3,4‐Dihydrothiacarbazol‐2(9H)‐one Skeleton by Using Bifunctional Squaramide‐Catalyzed Cascade Reactions.
Authors: Chen Shanren , Pan Jianping , Wang Youming , Zhou Zhenghong
Published: April 2015

This new tandem Michael addition/thiolysis reaction between indolinethione and N‐alkenoylphthalimides, catalyzed by a tert‐leucine‐derived, single chiral squaramide catalyst, proceeds smoothly to furnish structurally complex dihydrothiacarbazolones in satisfactory yields with moderate to high levels of enantioselectivity.
ChemInform Abstract: An Efficient Method for the Synthesis of N‐Amino‐2‐pyridones Using Reusable Catalyst ZnO Nanoparticles.
Authors: Safaei‐Ghomi Javad , Saberi‐Moghadam Mohammad Reza , Shahbazi‐Alavi Hossein , Asgari‐Kheirabadi Mehrnoosh
Published: April 2015

The title compounds (IV) are obtained by a concise and highly efficient four‐component one‐pot coupling of hydrazine hydrate, ethyl cyanoacetate (I), malononitrile (II), and various aromatic aldehydes (III) under mild reaction conditions.
ChemInform Abstract: Synthesis of Piperidones from Benzyl Azides and Acetone.
Authors: Han Junghoon , Rhee Young Ho , Park Jaiwook
Published: April 2015

Two equivalents acetone (II) are annulated with N‐unsubstituted imines, in‐situ generated from benzyl azines (I), using a ruthenium catalyst leading to 2,2‐dimethyl‐6‐substituted‐4‐piperidones (III) under mild reaction conditions.
ChemInform Abstract: Synthesis of Some New 2‐Substituted 4,5‐Dihydroxypiperidines via Sharpless Asymmetric Dihydroxylation.
Authors: Borah Arun Jyoti , Phukan Prodeep
Published: April 2015

Sharpless asymmetric dihydroxylation of tetrahydropyridines (II) affords the expected diols in high yields but only very poor enantioselectivity.
ChemInform Abstract: Synthesis of Novel 1,2,3‐Triazole Incorporated Quinoline Derivatives via Click Chemistry and Evaluation of Their Antimalarial Activity.
Authors: Mamgain Ritu , Atheaya Himanshu , Khan Shabana I. , Manohar Sunny , Rawat Diwan S.
Published: April 2015

None of the new title compounds (IV) and (VI) show any significant antimalarial activity, but they are found to be non cytotoxic indicating their safety in the mammalian system.
ChemInform Abstract: Synthesis of Multifunctional 3‐Amino‐4‐phosphono‐2‐quinolinones via Regioselective Ring Enlargement of Imino Isatins.
Authors: Wen Xiaojing , Chen Jing , Peng Yungui
Published: April 2015

The title compounds are prepared by one‐pot nucleophilic addition and regioselective ring enlargement of imino isatins.
ChemInform Abstract: Iron(III) Chloride Catalyzed Synthesis of Highly Substituted Indolyl‐Tetrahydroquinoline Derivatives by Using Indolylnitroalkene as Dienophiles and Its Application to the Synthesis of Indolo‐Benzonaphthyridine Derivatives.
Authors: Zanwar Manoj R. , Gawande Sachin D. , Kavala Veerababurao , Kuo Chun‐Wei , Yao Ching‐Fa
Published: April 2015

An efficient iron(III) chloride catalyzed synthesis of highly substituted indolyltetrahydroquinoline derivatives from easily available starting materials, including indolylnitroalkenes, substituted anilines and various aldehydes is reported.
ChemInform Abstract: Heterogeneous Copper‐Catalyzed Cascade Reactions of 2‐Bromobenzamides with β‐Keto Esters Leading to Isoquinolin‐1(2H)‐one Derivatives.
Authors: Zhao Hong , Wu Yichao , Wei Tin , Cai Mingzhong
Published: April 2015

The MCM‐41‐immobilized bidentate nitrogen copper(I) complex used as heterogeneous copper catalyst can be recovered and reused ten times without significant loss of activity.
ChemInform Abstract: A Facile Synthesis of Novel Tricyclic 4‐Pyridones.
Authors: Xu Buzhe , Cheng Zhanling , Fu Lei
Published: April 2015

A facile and mild protocol for an intramolecular Heck coupling reaction to produce tricyclic 4‐pyridones is presented.
ChemInform Abstract: Construction of Erythrinane Skeleton via Pd(0)‐Catalyzed Intramolecular Dearomatization of para‐Aminophenols.
Authors: Xu Ren‐Qi , Gu Qing , Wu Wen‐Ting , Zhao Zhuo‐An , You Shu‐Li
Published: April 2015

A novel Pd(0)‐catalyzed intramolecular arylative dearomatization of substrates having a p‐aminophenol subunit and an alkyl tether bearing an ortho‐haloaryl substituent is shown to yield products representing the erythrinane skeleton and related spirocyclic compounds.
ChemInform Abstract: N‐Tosyl‐3‐azacyclohexyne. Synthesis and Chemistry of a Strained Cyclic Ynamide.
Authors: Tlais Sami F. , Danheiser Rick L.
Published: April 2015

A straightforward synthesis of the silylated tetrahydropyridinyl trifluoromethanesulfonate (VI) is developed and the product is utilized as precursor of N‐tosyl‐3‐azacyclohexene, which is readily trapped by Diels—Alder reaction, 1,3‐dipolar cycloaddition, [2 + 2] cycloaddition reaction, thiophenol or Bu3SnH to give products with excellent levels of regioselectivity.
ChemInform Abstract: Study on One‐Pot Biginelli‐Like Synthesis of Pyrazolo[3,4‐d]pyrimidines in Broensted Acidic Ionic Liquid under Sonication and Its Mechanism.
Authors: Thummar Bhautik B. , Tarpada Umesh P. , Raval Dipak K.
Published: April 2015

12 Title compounds of type (IV) are prepared by a Biginelli‐like reaction under sonication in an ionic liquid.
ChemInform Abstract: A Novel Ruthenium‐Catalyzed Dehydrogenative Synthesis of 2‐Arylquinazolines from 2‐Aminoaryl Methanols and Benzonitriles.
Authors: Chen Mengmeng , Zhang Min , Xiong Biao , Tan Zhenda , Lv Wan , Jiang Huanfeng
Published: April 2015

A novel method for the convenient synthesis of 2‐arylquinazolines is presented that is operationally simple and avoids the use of halogenated reagents.
ChemInform Abstract: Uncatalyzed Synthesis of Furo(2,3‐d)pyrimidine‐2,4(1H,3H)‐diones in Water and Their Antimicrobial Activity.
Authors: Sambavekar P. P. , Aitawade M. M. , Kolekar G. B. , Deshmukh M. B. , Anbhule P. V.
Published: April 2015

A variety of new furopyrimidinedione derivatives (IV) (12 examples) are synthesized by an environmentally‐friendly three‐component condensation reactions.