bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancement of Plant Regeneration in Lemon Balm (Melissa officinalis L.) with Different Magnetic Field Applications
Authors: ULGEN Canan , YILDIRIM Arzu , TURKER Arzu
Published: May 2020

Melissa officinalis L. (lemon balm) is a valuable medicinal and aromatic plant in the Lamiaceae family. Two independent experiments were performed to improve the productivity of the plant regeneration. Firstly, the most efficient in vitro culture system of M. officinalis was determined using 7 different explant types (leaf, petiole, stem, root, axillary buds, shoot buds and cotyledon buds) on medium containing Murashige and Skoog minimal organics (MSMO) medium with different concentrations and combinations of plant growth regulators (PGRs). Micropropagation was obtained only with explants containing meristematic cells (axillary buds, shoot tip buds and cotyledon buds). Lemon balm had a very low regeneration capacity and in the second part of the experiment, enhancement of regeneration was aimed with the applications of different magnetic fields (MFs). Two different MFs (50 and 100 mT) were generated using neodymium block magnets. There was no MF exposure with control treatment. Three different explants (axillary, shoot tip and cotyledon buds) were cultured on media including BA in combination with indole-3-acetic acid (IAA) or naphthalene acetic acid (NAA) with the application of two different MFs at 1 hour duration. As a result, it was determined that MF applications enhanced the regeneration capacity of M. officinalis and the best shoot formation was observed with axillary bud explant cultured in 1.5 mg/L BA at 100 mT MF application for 1 hour duration.
“Özel Eğitimde Psikolojik Danışma ve Rehberlik Hizmetleri” Dersinin Psikolojik Danışman Adaylarının Özel Eğitimde Öz-Yeterlik Algılarına Etkisi
Authors: SÖNMEZ Nesrin , KOÇYİĞİT Melike
Published: May 2020

Bu çalışmada, psikolojik danışman adaylarıyla yürütülen
“Özel Eğitimde Psikolojik Danışma ve Rehberlik
(PDR) Hizmetleri” dersinin, adayların özel eğitimde öz-yeterlik algılarına
etkisini incelemek amaçlanmıştır. Yarı-deneysel nitelikte olan çalışmada
ön-test, son-test kontrol gruplu (2x2) desen kullanılmıştır. Çalışmanın
katılımcıları, 2017-2018 bahar yarıyılında Rehberlik ve Psikolojik Danışma
programında öğrenim gören 4. sınıf psikolojik danışman adaylarıdır (n=45). Son
sınıf müfredatında seçmeli ders olan “Özel Eğitimde PDR
Hizmetleri”
dersini seçen 24 aday deney grubunu, başka bir dersi seçen 21 aday da kontrol
grubunu oluşturmuştur. Adayların özel eğitimde
öz-yeterlik algılarına etkisini belirlemek üzere “Kişisel Bilgi
Formu” ve “Rehber
Öğretmen Özel Eğitim Öz Yeterlik Ölçeği” kullanılmıştır. Verilerin analizinde “tekrarlı
ölçümler için ANOVA” ve t-testi kullanılmıştır. 14 hafta boyunca yüzyüze
eğitimler, okul ziyaretleri, deneyim paylaşımı, doküman inceleme gibi
süreçlerle yürütülen dersin sonunda, deney grubundaki psikolojik danışman
adaylarının özel eğitim özyeterlik algı düzeyi kontrol grubuna göre anlamlı
düzeyde artmıştır. Psikolojik danışman adaylarının lisans eğitiminde özel
eğitim alanında yeterlik kazandıracak nitelikte derslerin açılması yönünde
önerilere yer verilmiştir.
Data Privacy, What Still Need Consideration in Online Application System?
Authors: Puspa Dewi , Soegiharto Adhiawan , Nizar Hidayanto Achmad , Munajat Qorib
Published: May 2020

This paper aims to conduct an analysis and exploration of matters that still needs to be considered in relation to data privacy in the online application system. This research is still a preliminary study. We conduct research related to data privacy using systematic literature review approach (SLR). Bt using SLR stages, we made a synthesis of 44 publications from Scopus Database Online that were released in the range 2015 - 2019. Based on this study, we found six things points to consider in data privacy, namely security and data protection, user awareness, risk managment, control setting, ethics, and transparency.
USP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer
Authors: Lei Xuemeng , Li Xukun , Chen Hongyan , Liu Zhihua
Published: May 2020

Background:

Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating
enzymes (DUBs) family. However, the function of USP48 in ovarian cancer remains unclear.

Objective:

The present study reveals that USP48 knockdown could significantly inhibit cell migration
and invasion in ES2, 3AO and A2780 cells, without affecting cell proliferation.

Methods:

After carboplatin (CBP) treatment, the USP48 ablation increases the apoptosis rate, and
the cleaved PARP and cleaved caspase 3 expression levels in ES2, 3AO and A2780 cells. The subcutaneous
tumor and intraperitoneally injected experiments demonstrated that the USP48 knockdown
significantly increases responsiveness to CBP, and alleviates the metastasis in vivo. Meanwhile,
USP48 deficiency results in the improved survival of mice.

Results:

Finally, the analysis of clinical samples and the TCGA and Kaplan-Meier Plot database revealed
that the high expression of USP48 in ovarian cancer patients is associated with poor survival
and resistance to CBP therapy.

Conclusion:

In summary, USP48 may be a potential therapeutic target for ovarian cancer patients.
An Overview on Steroids and Microwave Energy in Multi-Component Reactions towards the Synthesis of Novel Hybrid Molecules
Authors: Borah Preetismita , Shivling Vhatkar Dattatraya , Banik Bimal Krishna , Sahoo Biswa Mohan
Published: May 2020

In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon- Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.
MicroRNA 21 Emerging Role in Diabetic Complications: A Critical Update
Authors: Roy Dipayan , Modi Anupama , Khokhar Manoj , Sankanagoudar Shrimanjunath , Yadav Dharamveer , Sharma Shailja , Purohit Purvi , Sharma Praveen
Published: May 2020

Background:

Diabetes Mellitus is a multifactorial disease encompassing various pathogenic
pathways. To avoid morbidity and mortality related to diabetic complications, early detection of disease
complications as well as targeted therapeutic strategies are essential.

Introduction:

MicroRNAs (miRs) are short non-coding RNA molecules that regulate eukaryotic posttranscriptional
gene expression. MicroRNA-21 has diverse gene regulatory functions and plays a significant
role in various complications of Type 2 diabetes mellitus (T2DM).

Methods:

The study included electronic database searches on Pubmed, Embase, and Web of Science
with the search items MicroRNA21 and each of the diabetic complications. The search was carried out
up to November, 2019.

Results:

MicroRNA-21 modulates diabetic cardiomyopathy by affecting vascular smooth muscle cell
proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. At the renal
tubules, miR-21 can regulate the mesangial expansion, interstitial fibrosis, macrophage infiltration,
podocyte loss, albuminuria and fibrotic and inflammatory gene expression related to diabetic nephropathy.
Overexpression of miR-21 has been seen to play a pivotal role in the pathogenesis of diabetic retinopathy
by contributing to diabetes-induced endothelial dysfunction as well as low-grade inflammation.

Conclusion:

Considering the raised levels of miR-21 in various diabetic complications, it may prove to
be a candidate biomarker for diabetic complications. Further, miR-21 antagonists have shown great potential
in the treatment of diabetic cardiomyopathy, diabetic nephropathy, diabetic retinopathy, and diabetic
neuropathy related complications in the future. The current review is the first of its kind encompassing
the roles miR-21 plays in various diabetic complications, with a critical discussion of its future
potential role as a biomarker and therapeutic target.
Selection of Cowpea Elite Lines for Iron and Zinc Biofortification
Authors: C. Dias-Barbosa Cristina Z. de Morais , de Oliveira Diego S.V. , de Oliveira Kaesel J.D. , dos Reis Moreira Araújo Regilda S. , de Moura Rocha Maurisrael
Published: May 2020

Background:

Cowpea is a very popular crop in Brazil, rich in nutrients that can be used as
food to feed the population, avoiding deficiencies caused by the lack of minerals such as iron and
zinc.

Objective:

To select elite cowpea lines for biofortification of iron and zinc and determine
the physical and chemical characteristics of the lines. We analyzed: 33 cowpea genotypes, being 31
elite genotypes and two biofortified cultivars (control).

Method:

The 10 best lines with iron and zinc contents were selected and, together with the controls,
were analyzed for chemical composition (moisture, ash, lipids, proteins and carbohydrates), total energy
value and cooking time.

Results:

The iron and zinc contents in semi-prostrate genotypes were higher than those in semi-erect
genotypes, all the semi-prostrate lines presented a high iron content, and 19.25% presented a high
zinc content. The genotypes of the semi-erect lines exhibited more significant genetic variability for
iron content, whereas those of the semi-prostrate genotypes showed more significant genetic variation
for zinc content, both exhibited a high genetic component in phenotypic expression. Improving
the genotypes for increased protein content led to reductions in lipid and carbohydrate contents, as
well as the total energy value, whereas increasing the carbohydrate content increased both the total
energy value and the zinc content. The MNC04-792F-146 lines presented alleles that favored an increase
in carbohydrate content and total energy, while the MNC04-769F-26, MNC04-769F-31, and
MNC04-774F-90 lines were shown to be good sources of genes for increasing protein content, decreasing
lipid content, and rapid cooking.

Conclusion:

The MNC04-762F-9, MNC04-792F-146, and MNC04-769F-55 lines exhibited the
greatest potential to be released as iron and zinc biofortified cultivars.
Microwave-assisted Extraction for Maximizing the Yield of Phenolic Compounds and Antioxidant Capacity from Cacao Pod Husk (Theobroma cacao L.)
Authors: Nguyen Van T. , Pham Thi D. , Vu Long B. , Nguyen Van H. , Tran Ngoc L.
Published: May 2020

Background:

Extraction is an important step to obtain phytochemical compounds from
natural materials. Among different extraction techniques, microwave-assisted extraction (MAE) is an
advanced method with high extraction efficiency and low energy consumption.

Objective:

This study aimed to optimize the MAE parameters for obtaining the highest levels of phenolic
compounds and antioxidant activity from cacao pod husk (CPH).

Methods:

The dried CPH was prepared using a microwave drying method. The CPH extract was
prepared using a microwave-assisted extraction method. The powdered CPH extract was prepared
using vacuum evaporation and freeze-drying methods. Phytochemical compounds and antioxidant
capacity of CPH extracts were analyzed using spectrophotometric methods.

Results:

The optimal MAE parameters were 600 W microwave power, 5 s/min irradiation time, 30
min extraction time, and 50 mL/g solvent to sample ratio. Under these MAE parameters, total phenolic
content (TPC), phenolic extraction efficiency (PEE), saponin content (SC), and DPPH radical
scavenging capacity (DRSC) were achieved from the CPH to be 10.97 mg GAE/g dried sample,
76.82%, 70.10 mg EE/g dried sample, and 141.18 mg DPPH/g dried sample, respectively, which
were not significantly different from the predicted values (10.38 mg GAE/g dried sample, 72.68%,
70.09 mg EE/g dried sample, and 121.49 mg DPPH/g dried sample, respectively). The residual moisture,
water activity, density, water-soluble index and pH of powdered CPH extract were 9.72%, 0.38,
0.17 g/ml, 84.93% and 7.68, respectively. TPC, total flavonoid content (TFC) and SC of powdered
CPH extract were 15.75 mg GAE/g dried sample, 27.03 mg CE/g dried sample and 133.67 mg EE/g
dried sample, respectively. DRSC and ferric reducing antioxidant power (FRAP) of powdered CPH
extract were 227.79 mg DPPH/g dried sample and 14.12 mg Fe(II)/g dried sample, respectively.

Conclusion:

The findings from this study reveal that the powdered extract obtained from the CPH at
the optimal MAE parameters is a rich source of phytochemicals possessing great antioxidant activity.
Therefore, it is a potential candidate to apply in functional foods.
Biochanin A Ameliorates Ovalbumin-induced Airway Inflammation through Peroxisome Proliferator-Activated Receptor-Gamma in a Mouse Model
Authors: Derangula Madhavi , Panati Kalpana , Narala Venkata R.
Published: May 2020

Objective:

Asthma is an inflammatory airway disease affecting most of the population in the
world. The current medication for asthma relieves airway inflammation but it has serious adverse
effects. Biochanin A (BCA), a phytoestrogen, is an active component present in red clover, alfalfa, soy
having anti-oxidant and anti-inflammatory properties. BCA was identified as a natural activator of
peroxisome proliferator-activated receptor-gamma (PPARγ).

Methods:

The study aims to evaluate the effects of BCA in ovalbumin (OVA)-induced murine model
of asthma and to study the role of PPARγ.

Results:

We found that BCA administration reduced the severity of murine allergic asthma as
evidenced histologically, and measurement of allergen-specific IgE levels in serum as well as in BAL
fluid. BCA also reversed the elevated levels of inflammatory cytokines, cell infiltration, protein
leakage into the airways and expression of hemoxygenase-1 in OVA-induced lungs. Further, we
confirmed that BCA mediated inhibitory effects are mediated through PPARγ as assessed by treatment
with PPARγ antagonist GW9662.

Conclusion:

Our results suggest that BCA is efficacious in a preclinical model of asthma and may
have the potential for the treatment of asthma in humans.
Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
Authors: El-Eshmawy Mervat M. , Gad Doaa F. , El-Baiomy Azza A.
Published: May 2020

Background:

Prediabetes, defined as impaired glucose tolerance and/or impaired fasting
glucose, is a risk factor for future type 2 diabetes, dyslipidemia, cardiovascular disease and all-cause
mortality. High serum levels of ischemia modified albumin (IMA) and malondialdehyde (MDA) as
oxidative stress markers were determined in diabetes, however, no studies have investigated these
markers together in prediabetes. The aim of the present study was to investigate the circulating levels
of both IMA and MDA in a cohort of prediabetic adults. The possible associations between both markers
and the atherogenic index of plasma (AIP) were also evaluated.

Methods:

This study enrolled 100 adults with prediabetes and 50 healthy controls matched for age and
sex. Anthropometric measurements, fasting and 2-hour post load glucose, glycosylated hemoglobin
(A1c), lipids profile, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR),
high sensitivity C-reactive protein (hs-CRP), AIP, IMA and MDA were assessed.

Results:

IMA, MDA, hs-CRP and AIP were significantly higher in adults with prediabetes than in
healthy controls. Male gender, fasting and post load glucose, A1c, fasting insulin, TGs, HDL-C, hs-
CRP, AIP and MDA were independent predictor variables of IMA, whereas male gender, WC, fasting
and post load glucose, A1c, fasting insulin, TC, TGs, LDL-C, HDL-C, hs-CRP and AIP were independent
predictor variables of MDA.

Conclusion:

The elevation of IMA concomitantly with MDA reflecting the antioxidant status in prediabetes,
and their associations with hs-CRP and AIP should reinforce the idea of screening and treatment
of prediabetes.
Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin
Authors: Yong David O.C. , Saker Sanggetha R. , Chellappan Dinesh K. , Madheswaran Thiagarajan , Panneerselvam Jithendra , Choudhury Hira , Pandey Manisha , Chan Yik L. , Collet Trudi , Gupta Gaurav , Oliver Brian G. , Wark Peter , Hansbro Nicole , Hsu Alan , Hansbro Philip M. , Dua Kamal , Zeeshan Farrukh
Published: May 2020

The application of medicinal plants has captured the interest of researchers in recent times
due to their potent therapeutic properties and a better safety profile. The prominent role of herbal products
in treating and preventing multiple diseases dates back to ancient history and most of the modern
drugs today originated from their significant sources owing to their ability to control multiple targets
via different signalling pathways. Among them, flavonoids consist of a large group of polyphenols,
which are well known for their various therapeutic benefits. Rutin is considered one of the attractive
phytochemicals and important flavonoids in the pharmaceutical industry due to its diverse pharmacological
activities via various underlying molecular mechanisms. It is usually prescribed for various
disease conditions such as varicosities, haemorrhoids and internal haemorrhage. In this review, we
have discussed and highlighted the different molecular mechanisms attributed to the various pharmacological
activities of rutin, such as antioxidant, anti-inflammatory, anticancer, anti-allergic and antidiabetic.
This review will be beneficial to herbal, biological and molecular scientists in understanding
the pharmacological relevance of rutin at the molecular level.
An Energy-Efficient and Reliable Opportunistic Routing for Wireless Sensor Networks
Authors: Kumar Nagesh , Singh Yashwant
Published: May 2020

Introduction:

Routing protocols in Wireless Sensor Networks (WSN) are of major concern
because of the important factors like energy efficiency and reliability. Opportunistic Routing
(OR) is the simplest and reliable routing technique for ad-hoc networks and WSN. The OR protocol
guarantees data delivery in the network. As WSN need energy-efficient routing, therefore, energy-
efficient OR protocols gained popularity in the last three years.

Objectives:

Opportunistic routing improves the performance of the network by utilizing the
broadcasting abilities of wireless channels. In this paper, a new energy-efficient and reliable routing
protocol has been proposed that is based on the opportunistic routing technique.

Methods:

The proposed protocol is based on the energy-efficient routing metric. The proposed
OR protocol prioritizes among the candidate forwarders on the basis of energy-efficient routing
metric and this will lead to the achievement of improved network lifetime.

Results:

The end-to-end delay is reduced because of the selection of candidate forwarders from
the neighbor list of each node. The proposed protocol uses selective acknowledgment mechanisms.
The simulation results of the proposed protocol depict the improved performance as compared
to other recent OR protocols.

Conclusion:

The proposed protocol can directly be used with existing WSN applications. Further
improvements can be made by utilizing more parameters like distance and the quality of transmission.
Success Rate of Obturation of Root Canals by Different Techniques in Primary Molars: A Comparative Clinical Study
Authors: Damle Satyawan G. , Bansal Ritika , Sakhare Dhanashree D.
Published: May 2020

Objective:

To compare the success rate of different obturation procedures in primary
mandibular second molars clinically and also by digital radiovisiography.

Methods:

A total of 40 children aged between 4-8 years with deeply carious mandibular second
primary molars indicated for single session pulpectomy were selected. Canals were obturated with
Metapex. The 3 study groups (Endodontic plugger, Handheld lentulospiral, Navi Tip syringe) were
compared with the control group (reamer) both clinically and radiovisiographically. The data collected
were statistically analyzed using Pearson’s Chi-square and Fisher’s exact test.

Results:

The use of Navi tip syringe led to the least number of voids followed by Endodontic plugger
and Reamer and the highest number of voids was reported with Lentulospiral. Navitip presented
maximum number of optimally filled cases followed by Endodontic plugger and Lentulospiral and
least number of optimally filled cases with reamer. However, there was no statistically significant
difference (p>0.05) in any of the groups with clinical (pain and tenderness to percussion) and radiographic
parameters (presence or absence of voids and length of obturation).

Conclusion:

Within the limitations of the present study, though the clinical outcome was statistically
insignificant, Navitip syringe exhibited encouraging results and is a promising option for obturation
in primary teeth.
Inovasi Financial Technology (Fintech) pada Asuransi Syariah (Studi kasus: PT Duta Danadyakasa Teknologi)
Authors: Nuranggraeni Indri
Published: May 2020

Fintech Asuransi
Wearable Activity Trackers for Monitoring Adherence to Home Confinement During the COVID-19 Pandemic Worldwide: Data Aggregation and Analysis (Preprint)
Authors: Pépin Jean Louis , Bruno Rosa Maria , Yang Rui-Yi , Vercamer Vincent , Jouhaud Paul , Escourrou Pierre , Boutouyrie Pierre
Published: May 2020

BACKGROUND

In the context of home confinement during the coronavirus disease (COVID-19) pandemic, objective, real-time data are needed to assess populations’ adherence to home confinement to adapt policies and control measures accordingly.

OBJECTIVE

The aim of this study was to determine whether wearable activity trackers could provide information regarding users' adherence to home confinement policies because of their capacity for seamless and continuous monitoring of individuals’ natural activity patterns regardless of their location.

METHODS

We analyzed big data from individuals using activity trackers (Withings) that count the wearer’s average daily number
of steps in a number of representative nations that adopted different modalities of restriction of citizens’ activities.

RESULTS

Data on the number of steps per day from over 740,000 individuals around the world were analyzed. We demonstrate the physical activity patterns in several representative countries with total, partial, or no home confinement. The decrease in steps per day in regions with strict total home confinement ranged from 25% to 54%. Partial lockdown (characterized by social distancing measures such as school closures, bar and restaurant closures, and cancellation of public meetings but without strict home confinement) does not appear to have a significant impact on people’s activity compared to the pre-pandemic period. The absolute level of physical activity under total home confinement in European countries is around twofold that in
China. In some countries, such as France and Spain, physical activity started to gradually decrease even before official commitment
to lockdown as a result of initial less stringent restriction orders or self-quarantine. However, physical activity began to increase
again in the last 2 weeks, suggesting a decrease in compliance with confinement orders.

CONCLUSIONS

Aggregate analysis of activity tracker data with the potential for daily updates can provide information regarding adherence to home confinement policies.
INFLUENCE OF PHARMACEUTICALINFLUENCE OF PHARMACEUTICAL CARE ACTIVITIES ON KNOWLEDGE ATTITUDE AND PRACTICE (KAP) AMONG DIABETIC PATIENTS IN A TERTI CARE ACTIVITIES ON KNOWLEDGE ATTITUDE AND PRACTICE (KAP) AMONG DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL
Authors: SHAILAJA K. , ABRAHAM ANJU , BHARGAVI BINDHU , DEVIKA R.
Published: May 2020

Objective: To assess the influence of pharmaceutical care activities on Knowledge, Attitude and Practice (KAP) among type 2 diabetic patients.

Methods: A total of about 301 patients with type 2 Diabetes Mellitus were recruited from a tertiary care hospital. Patients were educated about their disease condition, lifestyle modifications and diet regimen to be followed and were given instructions for improving medication adherence. In the initial session, no pharmaceutical care was given, in the second session patient counseling was given verbally and in the last session patient counseling was given both verbally and non-verbally by means of pamphlet distribution. KAP questionnaire and glycemic levels (glycated hemoglobin, fasting blood sugar and post-prandial blood sugar) of participants were obtained at baseline and at follow up.

Results: The baseline values of FBS in patients before intervention was found to be 176.5±74.46 mg/dL and it was reduced to 140.7±43.9 mg/dL after 3 mo. Henceforth, there was also an improvement in the PPBS values which was found to be 254±77.3 mg/dL at the baseline and was 212.9±54.2 mg/dL after intervention. The baseline values of HbA1c is 8.144±1.727% and after intervention, value reduced to about 7.173±2.768%. After the intervention, it was found to be that 30%, 16% and 12% reduction in FBS, PPBS and HbA1c values and the P-value (<0.0001) found to be statistically significant. KAP scores also found to be improved after the intervention and statistically significant. The results clearly indicate that through proper guidance and educating the patients by the pharmacist is beneficial in managing the glycemic levels and reduce further complications.

Conclusion: The study concluded that the pharmaceutical care by the pharmacist is highly essentially and useful for the patients to manage the glycemic index and prevent further diabetic complications.
POTENCY OF Γ-ORYZANOL-RICH BLACK RICE BRAN (ORYZA SATIVA L. INDICA) EXTRACT FOR TYROSINASE INHIBITION
Authors: VARDHANI AFIFAH , JUFRI MAHDI , PURWANINGSIH ERNI
Published: May 2020

Objective: The objectives of this study were to quantify γ-oryzanol in an ethanolic extract of Oryza sativa L. Indica (black rice) bran and to evaluate its activity as a tyrosinase inhibitor.

Methods: Black rice bran was extracted via maceration in 96% ethanol, and the γ-oryzanol concentration in the extract was measured through high-performance liquid chromatography. The applicability of the extract as a skin lightening agent was determined by evaluating its tyrosinase inhibition activity.

Results: The dry rice bran contained 118.572 mg/g of γ-oryzanol, and the extract inhibited tyrosinase activity at an IC50 of 74.8%.

Conclusion: The black rice bran extract was sufficiently potent for use in skin lightening formulations.
THERAPEUTIC APPROACH TO CONCURRENT PCP AND PULMONARY TB IN PEOPLE LIVING WITH HIV/AIDS WITH VARIOUS DRUG HYPERSENSITIVITY REACTIONS
Authors: SURYANA KETUT
Published: May 2020

Pneumocystis Carinii Pneumonia (PCP) and Pulmonary Tuberculosis (PTB) are the most frequent Opportunistic Infection (OI) in People living with HIV/AIDS (PLWHA), especially whose CD4 counts<200 cells/mL. There is no pathognomonic sign and symptom of pneumocystis, radiographic imaging (chest radiograph) and blood examination. An intractable microorganism cannot be isolated or sustained in culture. The diagnosis of PCP is complicated, based on the presumptive diagnosis. PCP should be treated optimally as soon as possible in order not to be fatal. We report a complicated case of a female 26 y-old, diagnosed with HIV infection on Highly Active Anti Retro Viral Therapy (HAART), PTB on Anti Tuberculosis Drugs (ATD) concurrent with PCP. She also has a history of various Drug Hypersensitivity Reactions (DHR) include Rifampycin, Ciprofloxacin and Cotrimoxazole. DHR is unpredictable, and Clindamycin and Primaquin are the recommended alternative drugs for PCP, the strategic therapy is by Desensitization Protocols.
National Security in Kautilya’s Arthashastra: A Content Analysis
Authors: Saad Muhammad , Wenxiang Liu
Published: May 2020

To understand the Indian strategic culture, one must understand Kautilya’s Arthashastra. Contemporary Indian national security preferences show a parallel resonance to the teachings of Kautilya’s Arthashastra. However, the existence of national security variable in Arthashastra has been undermined by most of the researches. This research attempts to explore the national security variable in Kautilya’s Arthashastra using summative content analysis. Results show that 69.88% of the text of Arthashastra is purely dedicated to national security issues. The interpretation proves that national security is the prime theme of Kautilya’s Arthashastra that has been systematically classified as Saptanga Theory and Mandala Theory. Its sole aim is real power politics and the securing of a state’s national security interests.
Parents’ perceptions over the use of New Technologies in Education
Authors: Kaltsidou Despoina , Tsairidis Charalampos , Dimitriadis Efstathios
Published: May 2020

This article analyses parents' views on the role that Information and Communication Technology (ICT) plays in the context of pedagogy. It also refers to parents' beliefs, fears and expectations towards new technologies. It uses data that were collected from primary schools and kindergartens of the region of Eastern Macedonian and Thrace in Greece. 1450 parents participated in this research, 869 were from primary schools and 581 from kindergartens. The results showed that parents (both from primary school and kindergarten) believe that new technologies help their children in the learning process and they believe that new technologies are beneficial for their children. Despite the fact that parents accept new technologies in their children's lives only for educational purposes, they don't want their children to spend a lot of time on the computer, because they are afraid that their children will not be able to socialize properly
Srbija i izazovi odbrambene diplomatije
Authors: Jojic Stefan
Published: May 2020

Prikaz knjige:

Veljko Blagojević, Srbija i izazovi odbrambene diplomatije, Medija centar Odbrana, Beograd, 2017.
PENENTUAN AUDIT FEE DITINJAU DARI KOMPLEKSITAS PERUSAHAAN, INTERNAL AUDIT DAN RISIKO AUDIT
Authors: Yusica Meithy , Sulistyowati Wiwit Apit
Published: May 2020

The audit fee is in return for a fee paid by the client entity for a public accountant based on a contractual agreement on providing audit services. This research aims was to analyse the influence of the company's complexity, internal audit and audit risk partially against the audit fee in manufacturing companies of consumer goods industry listed on the Indonesia Stock Exchange for the period 2014 to 2018. The selection of samples on this study was conducted using purposive sampling methods and obtained 80 samples. Multiple linear regression analysis was used in this research. The results of this study showed that a partially complexity of the company has positive effect on the audit fee, internal audit has negative affect on the audit fee and audit risk using both current ratio measurement and dummy variable loss no effect on the audit fee.
Percepción de pacientes con VIH/Sida sobre consulta odontológica en IPS de Santa Marta - Colombia
Authors: Vila-Sierra Luis Armando , Hernandez-Fuentes María Teresa
Published: May 2020

Introducción: La atención odontológica oportuna e inclusiva tiene un papel importante en las personas con VIH/SIDA, por cuanto permite prevenir y dar tratamiento a las múltiples lesiones orales que acompañan a esta patología, mejorando la calidad de vida de esta población. Objetivo: Determinar la percepción y experiencia de pacientes con VIH/SIDA sobre la consulta odontológica en una Institución Prestadora de Salud (IPS) de Santa Marta, Colombia. Materiales y métodos: Se realizó un estudio descriptivo cuantitativo donde participaron 64 pacientes con VIH/SIDA de una IPS de la ciudad de Santa Marta, quienes se les aplicó un instrumento de recolección de datos. Resultados: El 65,6% expresó nunca percibir rechazo por parte del odontólogo, el 25% refiere haber experimentado algún rechazo por lo menos una vez y un 9,4% siempre se siente rechazado. Conclusiones: Existe la necesidad de abordar esta enfermedad no sólo desde el aspecto clínico, sino también desde lo social, para educar tanto al profesional de la salud como a la comunidad, sobre avances científicos, el estudio de esta patología y los riesgos reales de contraerla, para desmitificar esta afección y erradicar la discriminación hacia los pacientes.
Relación entre clima organizacional y violencia laboral en funcionarios de una universidad pública
Authors: PantojaPantoja Anyi Katherine , Navarrete-Acosta Adriana Patricia , Zambrano-Guerrero Christian Alexander , Matabanchoy-Tulcán Sonia Maritza
Published: May 2020

Introducción: El clima laboral se relaciona con el acoso psicológico en el trabajo. No obstante, son escasos los estudios encontrados sobre la relación entre clima y violencia laboral en el contexto universitario. Objetivo: Analizar la relación entre el clima y la violencia laboral en funcionarios de una universidad pública. Materiales y métodos: Estudio descriptivo correlacional con diseño transversal, con la participación de 410 funcionarios. Se utilizó el Cuestionario de Clima Laboral del Departamento Administrativo de la Función Pública de Colombia (DAFP) y el Inventario de Violencia y Acoso Psicológico en el Trabajo IVAPT. Resultados: Se encontró que existe una relación negativa entre el clima y la violencia laboral (r=-0,441, p<0,005), en esta se resaltan estrechas asociaciones entre la dimensión obstáculos al desempeño laboral (ODL), y estilo de liderazgo (ED), administración del talento humano (ATH) y clima general. Conclusiones: La presencia de violencia laboral se relaciona con bajos niveles de favorabilidad de clima laboral y viceversa. Los comportamientos característicos de ODL y los referentes a manipulación para inducir al castigo (MIC) son los que aportan en mayor medida a esta desfavorabilidad. Este tipo de violencia, sin una debida intervención puede llegar a convertirse en acoso psicológico en el trabajo.
Flexibilidad, equilibrio dinámico y estabilidad del core para la prevención de lesiones en deportistas universitarios
Authors: Villaquiran-Hurtado Andrés , Molano-Tobar Nancy Janneth , Portilla-Dorado Enmanuel , Tello Andrés
Published: May 2020

Introducción: El deporte competitivo demanda un intensivo acondicionamiento físico que conlleva a un mayor riesgo de lesión que afectan la salud, el rendimiento físico, la participación en los entrenamientos, las competencias y los logros deportivos. Objetivo: Determinar las características de la estabilidad del core, el equilibrio dinámico de miembros inferiores y la flexibilidad en deportistas universitarios. Materiales y métodos: Estudio de corte transversal, con 86 deportistas universitarios que corresponden al 25% de la población. Se evaluó la estabilidad del core, el equilibrio dinámico de miembros inferiores y flexibilidad de la cadena posterior, hombro y cadera; se tuvo en cuenta la guía de valoración para la prevención de lesiones del lineamiento de política pública en ciencias del deporte. Resultados: El 83,7% de atletas presentaron un índice de masa corporal normal, el 47,5% mostró una flexibilidad promedio en el Sit and Reach, sin presencia de retracciones en cadera. Respecto al core el 77,9% de los participantes presentaron una mala estabilidad y el 47% riesgo de lesión, producto de las diferencias entre las extremidades inferiores en el equilibrio dinámico. Conclusiones: Los resultados sugieren implementar programas de prevención de lesiones para deportistas universitarios.
Efectos de la rehabilitación pulmonar sobre calidad de vida y tolerancia al esfuerzo
Authors: Betancourt-Peña Jhonatan , Ávila-Valencia Juan Carlos , Muñoz-Erazo Beatriz Elena , Hurtado-Gutiérrez Hugo , Benavides-Córdoba Vicente
Published: May 2020

Introducción: La rehabilitación pulmonar (RP) es una intervención que disminuye los síntomas de la Enfermedad Pulmonar Obstructiva Crónica (EPOC), incrementa la tolerancia al ejercicio, el estado emocional, la funcionalidad, la participación y la percepción de control de la enfermedad, mejorando la calidad de vida. Objetivo: Describir los efectos de la RP sobre dos escalas de calidad de vida y su influencia en la capacidad aeróbica funcional en pacientes con EPOC. Materiales y métodos: Estudio cuasiexperimental en pacientes que asistieron a RP. La capacidad aeróbica funcional se evaluó con el test de caminata de 6 minutos y la calidad de vida relacionada con la salud con los cuestionarios St. George Respiratory Questionnaire (SGRQ) y Chronic Respiratory Disease Questionnaire (CRQ-SAS). Resultados: Diferencias significativas en test de caminata de 6 minutos 51.9±44.5 metros; p<0.001. El SGRQ en actividad (inicial:65.9±16.8 y final 50.8±19.5; p<0.001), síntomas (inicial 45±17.9; final 33.6±16.8; p=0.005), impacto (inicial 40.5±16.4; final 31.8±18.1; p=0.004) y total (inicial 49.8±14.8; final 40.7±17.7; p=0.002). El CRQ-SAS en disnea (inicial 3.8±1.3; final 4.7±1.1; p<0.001), emocional (inicial 5.1±1 final 5.7±0.9; p<0.001) y total (inicial 4.6±0.9 final 5.3±0.8; p<0.001). Conclusiones: La RP favorece la calidad de vida evaluada con el SGRQ y el CRQ-SAS y la capacidad aeróbica funcional de los pacientes con EPOC.
Recomendaciones prácticas para evitar el desacondicionamiento físico durante el confinamiento por pandemia asociada a COVID-19
Authors: Mera Andry Yasmid , Tabares-Gonzalez Esteban , Montoya-Gonzalez Santiago , Muñoz-Rodriguez Diana Isabel , Monsalve Vélez Felipe
Published: May 2020

Introducción: El aislamiento social durante la pandemia por COVID-19 incluye el confinamiento en casa, que redunda en incremento de la inactividad física y de comportamientos sedentarios, favoreciendo el desacondicionamiento físico. Las personas desacondicionadas físicamente tienen alteraciones metabólicas y sistémicas por la falta de movimiento. Objetivo: Presentar recomendaciones prácticas, y de bajo costo sobre actividades basadas en la evidencia para evitar el desacondicionamiento físico durante el confinamiento en casa, que se pueden mantener a largo plazo, incluso después de la pandemia. Materiales y métodos: Revisión documental sobre estrategias para conducir estilos de vida saludable en casa que disminuyan los efectos negativos a nivel fisiológico producidos por el confinamiento derivado de la pandemia. Resultados: La evidencia señala que el confinamiento en casa incrementa los niveles de inactividad física y el comportamiento sedentario; la realización de actividad física bajo condiciones particulares puede entre otros, fortalecer el sistema respiratorio e inmunológico, mantener la condición física y generar efectos positivos sobre la salud mental. Conclusiones: Los hábitos relacionados con la práctica de actividad física en casa se deben mantener en el tiempo, se recomienda realizarla de manera programada, establecer horarios de descanso entre las actividades y durante la noche, y elegir aquellas que generen disfrute.
Violencia de género: Un análisis evolutivo del concepto
Authors: Jaramillo-Bolivar Cruz Deicy , Canaval-Erazo Gladys Eugenia
Published: May 2020

Introducción: Un concepto es una idea acerca de algo o de una acción. Objetivo: Analizar el concepto “Violencia de Género” desde la perspectiva evolutiva de Rodgers. Materiales y métodos: Se utilizó el análisis evolutivo de conceptos mediante revisión de literatura publicada entre los años 2000 y 2018. Criterios de inclusión: Artículos de investigación, de implementación de estrategias, de política, tesis, libros, capítulos de libro y reportes, en las bases de datos Lilacs, Ebsco, SciELO, CINAHL, Web of Science, PubMed, Google Académico; también se incluyeron documentos de organizaciones, publicados del año 2000 al año 2018, en Español, Inglés o Portugués, y que pertenecieran al contexto iberoamericano. Resultados: La Violencia de género consiste en un fenómeno de orden estructural, social y político; resultado de la discriminación estructural originado por un sistema sexo-género-patriarcado. Se encontraron términos relacionados como inequidad de género, control, relaciones asimétricas y términos subrogados como violencia de pareja, contra la mujer y doméstica. Conclusiones: La violencia de género, constituye una violación a los derechos humanos, afecta la dignidad, la integridad física y moral, la libertad y la autonomía.
Estrategia de búsqueda de información científica aplicada al reintegro laboral de personas con discapacidad
Authors: Galarza-Iglesias Ana Milena
Published: May 2020

Introducción: El ejercicio de la práctica profesional relacionado con el reintegro laboral de personas con discapacidad, debe soportar su actuar en la evidencia científica. Con el avance de las tecnologías de información y comunicación se tiene acceso a un gran acervo de resultados de investigaciones, a las cuales se pueden acceder a través del uso de estrategias de búsqueda. Objetivo: Evidenciar la pertinencia de una estrategia de búsqueda para recuperar publicaciones científicas relacionadas con el reintegro laboral de personas con discapacidad. Materiales y métodos: Se presenta de forma sistemática la estrategia de búsqueda a partir de definición de la pregunta, identificación de términos de búsqueda en lenguaje común y controlado, ecuación de búsqueda, búsqueda-recuperación de artículos, criterios inclusión-exclusión, selección de artículos, lectura crítica y respuesta a pregunta de investigación. Lo anterior puede ser reproducido ajustando descriptores según el interés profesional. Resultados: Se recuperaron 15 artículos que responden a la pregunta ejemplo, evidenciando la pertinencia de la estrategia de búsqueda. Conclusiones: La estrategia de búsqueda de información académica propuesta, permite recuperar artículos que son pertinentes para el investigador y profesionales en su práctica diaria.
Moldeado nasoalveolar prequirúrgico de un paciente con labio y paladar hendido unilateral izquierdo
Authors: Rodríguez-Solano María Paulina , Vergara-Mercado Martha Ligia
Published: May 2020

Introducción: El labio y paladar hendido son malformaciones craneofaciales que se presentan en 1:1000 nacidos vivos en Colombia. Realizar un moldeado nasoalveolar previo a la cirugía favorece el reposicionamiento de los cartílagos nasales deformados y de los procesos alveolares. Objetivo: Dar a conocer a los profesionales la importancia de realizar moldeado nasoalveolar en un paciente con labio y paladar hendido antes de la intervención quirúrgica. Materiales y métodos: En la clínica odontológica de la Universidad del Sinú de Montería (Córdoba, Colombia), se atendió una paciente de 17 días de nacida que presentaba labio y paladar hendido completo unilateral izquierdo severo. Luego de diligenciar la historia clínica odontológica, se realizó placa de órtesis, que se cambió cada 15 días y se hizo el retoque del “tutor” cada 8 días. Resultados: La placa de órtesis permitió un moldeado naso alveolar, con el progreso en la alimentación y mejoras en el contorneado de los tejidos nasales, que mejoró la preparación para la operación de la hendidura a los 8 meses de edad. Conclusiones: La importancia del moldeado nasoalveolar en casos como el presentado, es propiciar mejores condiciones físicas, favoreciendo la ingesta de alimentos y beneficiando la apariencia física.
Improvement of the cold resistance of the 09G2S steel by programmed hardening combined with additional medium-temperature tempering
Authors: Olenin M. I. , Gorynin V. I. , Makhorin V. V.
Published: May 2020

The article discusses a method of improving the cold resistance of steels of a ferrite-pearlite class. It has been established that the process of programmed hardening, combined with an additional medium temperature tempering, has a positive effect on the cold resistance of thermally improved 09G2S steel. The mechanical properties of steel grade 09G2S were determined before and after additional tempering at mediumtemperature. It is shown that the new technology allows the critical temperature of brittleness, determined by the criterion of the energy intensity of failure, to be shifted to lower temperatures by 15°C, and at the same time to increase the impact strength of 09G2S steel three times more at a temperature of minus 90°C without changing its strength properties.
Influence of niobium microalloying on the kinetics of static and dynamic recrystallization during hot rolling of medium-carbon high-strength steels
Authors: Knyazyuk T. V. , Novoskoltsev N. S. , Zisman A. A. , Khlusova E. I.
Published: May 2020

The temperature-strain conditions of dynamic and static recrystallization during hot deformation were determined at a rate of 1 sec–1 for medium-carbon steel microalloyed with titanium, boron, and vanadium containing different amounts of niobium. It was found that under hot rolling conditions niobium prevents the completion of dynamic recrystallization, and at temperatures below 970°C it drastically slows down static recrystallization in the pauses between successive reductions.
Nanocomposite coating with high microhardness based on the agglomerated Kh20N80-WC powder system
Authors: Bobkova T. I. , Vasiliev A. F. , Samodelkin E. A. , Farmakovsky B. V.
Published: May 2020

This article explores the characteristic and particular features of manufacturing nanostructured composite coatings with high microhardness from agglomerated powders of Kh20N80-WC system manufactured by high-speed mechanosynthesis. The properties of the functional coatings deposited by both supersonic cold gas-dynamic and microplasma spraying are studied.
Electrochemical deposition of nanocrystalline Ni–W coatings from citrate electrolytes
Authors: Krasikov A. V. , Bykova A. D. , Merkulova M. V. , Markov M. A.
Published: May 2020

In this paper, requirements for wear-resistant coatings of Ni–40%W manufactured by electrochemical deposition are determined, and the electrolyte stability is studied. The influence of temperature and current density on the deposition of the Ni–W alloy from a citrate electrolyte was researched, and the optimal deposition mode was found. The maximum operating time of the electrolyte is established by the dependence of the current efficiency for the Ni–W alloy on the electric power transmission. The necessity of using membrane electrolyzers during the deposition of nickel-tungsten coatings is substantiated.
Wear behaviour of metals in dry sliding against molybdenum with current collection
Authors: Aleutdinova M. I. , Fadin V. V.
Published: May 2020

The possibility of high electrical conductivity of dry sliding electrical contact against molybdenum counterbody was studied. It was found that metals W and Cu were not able to form a sliding electrical contact with high wear resistance at current density higher 100 A/cm2 . The characteristics of the contacts of iron containing metals were slightly better than the contact characteristics of non-ferrous metals due to weaker adhesion. Using X-ray phase analysis, it was shown the absence of oxides in the sliding zone of non-ferrous metals. This led to their strong wear and contact’s low electrical conductivity. In the contact zone of iron containing samples the formation of FeO was observed that made it possible to reduce wear. This means that high electrical conductivity is unattainable in sliding with current collection against molybdenum.