bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of the Prolong Life With Nine Turn Method (Yan nian jiu zhuan) Qigong on patients with chronic fatigue syndrome: Study protocol for a randomized controlled trial
Authors: xie Fangfang , You Yanli , Yang Wenjia , Tian Jiancai , Guan Chong , Cheng Ziji , Yao Fei
Published: August 2019

Background

Chronic fatigue syndrome (CFS) is characterized by persistent fatigue, which often leads to physical and psychological damage. However, there is currently no clear explanation for this syndrome. Most treatments are based on symptoms, and cognitive behavioral therapy (CBT) is considered to be one of the most effective treatments. Little is known about the Prolong Life With Nine Turn Method (PLWNT) Qigong, a combination of complex two-way traffic path connecting the cognitive center and the enteric nerves. In this study protocol, we explored the effectiveness of PLWNT on gastrointestinal function, physical and mental fatigue, and sleep quality in patients with CFS.

Methods/design

A randomized controlled trial consisting of 90 patients will be divided into treatment A and B groups. The treatment group will be treated with either CBT or PLWNT. Both treatment groups will include a supervised intervention at the Shanghai University of Traditional Chinese Medicine once a week, and the remaining six days will be completed at home over 12 consecutive weeks. Both treatments will take three months. Qualified participants in accordance with the inclusion criteria and signed informed consent will be recruited. The primary outcome variable is to explore the regulation mechanism of the brain-gut axis in patients with chronic fatigue and the Multidimensional Fatigue Inventory (MFI-20). Secondary outcomes are the Short Form 36-item Health Survey (SF-36), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS), which will be completed before and after the intervention.

Discussion

This will be the first randomized controlled clinical trial to introduce the PLWNT method for the treatment of CFS. If our results demonstrate that CBT or PLWNT nterventions are more effective, this will provide a quality treatment for patients with chronic fatigue and optimize their guidance.
Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)
Authors: Hurley Deirdre , Jeffares Isabelle , Hall Amanda M , Keogh Alison , Toomey Elaine , McArdle Danielle , Lonsdale Chris , McDonough Suzanne M , Guerin Suzanne , Segurado Ricardo , Matthews James
Published: August 2019

Background

The Self-management of Osteoarthritis (OA) and Low back pain (LBP) through Activity and Skills (SOLAS) theory-driven group-based complex intervention was developed primarily for the evaluation of its acceptability to patients and physiotherapists and the feasibility of trial procedures, to inform the potential for a definitive trial.

Methods

This assessor-blinded multicentre two-arm parallel cluster randomised controlled feasibility trial compared the SOLAS intervention to usual individual physiotherapy (UP; pragmatic control group). Patients with OA of the hip, knee, lumbar spine and/or chronic LBP were recruited in primary care physiotherapy clinics (i.e. clusters) in Dublin, Ireland between September 2014 and November 2015. The primary feasibility objectives were evaluated using quantitative methods and individual telephone interviews with purposive samples of participants and physiotherapists. A range of secondary outcomes were collected at baseline, 6 weeks (behaviour change only), 2 months and 6 months to explore the preliminary effects of the intervention. Analysis was by intention-to-treat according to participants’ cluster allocation and involved descriptive analysis of the quantitative data and inductive thematic analysis of the qualitative interviews. A linear mixed model was used to contrast change over time in participant secondary outcomes between treatment arms, while adjusting for study waves and clusters.

Results

14 clusters were recruited (7 per trial arm), each cluster participated in two waves of recruitment, with the average cluster size below the target of six participants (Intervention: mean (SD) =4.92 (1.31), range 2-7; UP: mean (SD) =5.08 (2.43), range 1-9). 120 participants (83.3% of n=144 expected) were recruited (Intervention n=59; UP n=61), with follow up data obtained from 80.8% (n=97) at 6 weeks, 84.2% (n=101) at 2 months and 71.7% (n=86) at 6 months. Most participants received treatment as allocated (Intervention n=49; UP n=54). The qualitative interviews (12 participants; 10 PTs) found the Intervention and trial procedures acceptable and appropriate, with minimal feasible adaptations required. Linear mixed methods showed improvements in most secondary outcomes at 2 and 6 months with small between group effects.

Conclusions

While the SOLAS intervention and trial procedures were acceptable to participants and PTs, the recruitment of enough participants is the biggest obstacle to a definitive trial.

Trial Registration: ISRCTN Registry, ISRCTN49875385, Registered 26 March 2014. https://doi.org/10.1186/ISRCTN49875385
Clinical analysis of Kimura’s disease in 24 cases from China
Authors: Zhang Guoliang , Qi Weidong , Li Xumao , Sun Guangbin , Cao Yitan , Gao Nan
Published: August 2019

Background

We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD.

Methods

A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis.

Results

In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%).

Conclusions

Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.
Influence of complete uncinate process removal on 2-year assessment of radiologic outcomes: subsidence and sagittal balance in patients receiving one-level anterior cervical discectomy and fusion
Authors: Noh Sung Hyun , Park Jeong Yoon , Kuh Sung Uk , Chin Dong Kyu , Kim Keun Su , Cho Yong Eun , Kim Kyung Hyun
Published: August 2019

Background: Many patients who appealed cervical radiculopathy have stenosis of neural foramens because of cumulative osteophyte or uncovertebral joint hypertrophy. For cervical foraminal stenosis, complete UPR conducted concurrently with ACDF. The aim of this study was to evaluate the clinical and radiological consequences of complete uncinate process resection (UPR) during anterior discectomy and fusion (ACDF) versus those seen with ACDF without UPR.

Methods: In total, 105 patients who underwent one-level ACDF with a cage-and-plate construct between 2011 and 2015 were retrospectively reviewed. Among them, 37 underwent ACDF with complete UPR, and 68 underwent ACDF without UPR. Radiographic parameters of disc height, C2–C7 lordosis, T1 slope, C2–C7 sagittal vertical axis (SVA), center of the sellar turcica–C7 SVA (St-SVA), spinocranial angle (SCA), and fusion rate were measured on plain radiographs at pre-operation, immediately post-operation, and during the follow-up period (median follow-up duration: 37.7 ± 10.5 months).

Results: Improvement in Visual analogue scale (VAS) score for arm pain was significantly better in the ACDF with complete UPR group immediately post-operation. Fusion rates, C2–C7 lordosis, T1 slope, and C2–C7 SVA after single-level ACDF were not significantly different between the two groups (p>0.05). Subsidence occurred in 23 patients (ACDF with complete UPR: 14 cases [37%] versus ACDF without UPR: 9 cases [13%]; p < 0.05).

Conclusions: Cervical sagittal alignment after ACDF with complete UPR is not significantly different from that achieved with ACDF without UPR. However, subsidence occurred more frequently after ACDF with complete UPR than after ACDF without UPR, although there was no clinical impact. More precise and careful selection of patients is needed when deciding on additional complete UPR.
Factors associated with child health service delivery by female community health volunteers in Nepal: Findings from a national survey
Authors: Bhattarai Hari Krishna , Khanal Pratik , Khanal Vishnu , Regmi Kiran , Paudel Narendra Raj , Dhakal Liladhar , Singh Samikshya
Published: August 2019

Background
Nepal has made a significant improvement in child survival in the last few decades and the involvement of female community health volunteers (FCHVs) has been crucial in such achievement. While there have been a lot of documented studies and reports, rarely has been explored the status and factors associated with the child health service provided by these volunteers. This study aimed to measure the child health service delivery status by FCHVs and its associated factors.

Methods
A national survey was conducted in 2014 in Nepal that included 4,302 FCHVs using the structured questionnaire across the 13 geopolitical domains of the country. The data was extracted and the association of child health services with characteristics was examined using Chi-square test (χ2) followed by logistic regression.

Results
Two out of three FCHVs provided at least one child health service. Those FCHVs who utilized money from the FCHV fund, conducted mothers’ group meeting, involved in the local committees and those who supported in antenatal care related activities were more likely to provide child health services. Similarly, FCHVs having the stock of cotrimoxazole tablet, Zinc tablet, oral rehydration salt were also more likely to provide child health services. Province wise analysis showed that FCHVs from Province 5 and Province 7 were more likely to provide child health services compared to their counterparts from province 1.

Conclusions
FCHVs are an important human resource in providing child health services in Nepal. To improve child health service delivery by FCHVs, availability of the key commodities, the involvement of FCHVs in regular health mothers’ group meeting, use of mobile phone, involvement in other health programs and social networks, and utilization of fund need to be taken into consideration.
The Spectrum of heart disease among adults at the Bamenda Regional Hospital, North west Cameroon: a semi urban setting
Authors: Akono Manuel Ndo , Simo Larissa Pone , Agbor Valirie Ndip , Njoyo Sylvain Laah , Mbanya Dora
Published: August 2019

Background

Non-communicable diseases are the leading causes of global mortality, and the second commonest cause in sub-Saharan Africa. They have been projected to drive mortality in sub-Saharan Africa by 2030.

Methods

This is a chart review of echocardiographic records of adult patients of the Imagery Centre of the Bamenda Regional Hospital in the North West Region of Cameroon. Data was collected for the period between July 2015 and April 2018, and included age, sex, comorbidities, ejection fraction and echocardiographic findings.

Results

In total, 673 records were included in our study, of which 506 had a definite heart disease. Amongst those with a definite heart disease, 93 had mixed cardiopathies. Their ages ranged from 18 – 105 years with a median age of 64.0 (Interquartile range [IQR] = 47 – 75) years. Females accounted for a greater proportion (55.3%) of the study population. The most common echocardiographic diagnoses were hypertensive heart disease (41.1%), valvular heart disease (22.3%) and cardiomyopathies (11.4%). The prevalence of heart failure was 17.5%, with hypertensive heart disease being the leading cause.

Conclusion

Hypertensive heart disease is the most common heart disease in this semi-urban setting in Cameroon. A significant proportion of the population has more than one heart disease (mixed cardiopathies).
Stroke in Maputo Central Hospital, Mozambique 2019: A Glimpse of Epidemic or Endemicity?
Authors: Baduro Yanina , Ndala Omer , Vaz Deise , Buque Helena , Sebastião Frederico , Baco Jamal , Arroz Nachan , Casas Carlos , Lorenzo Elder , Arroz Jorge
Published: August 2019

Objective The aim of this study is to determine the endemic/epidemic pattern of stroke in Maputo Central Hospital in the first semester of 2019. Results During the period 2014-18, there were 2,979 registered cases of stroke in MCH, ranging from 512 in 2017 and 687 in 2015. The mean monthly registered cases per year ranged from 43 in 2017 to 57 in 2015. The C-SUM+1.96SD and mean+2SD methods have the highest monthly thresholds comparing to C-SUM and 3rd quartile methods. An epidemic pattern of stroke was observed during the first semester of 2019 when 3rd quartile and C-SUM threshold epidemic method was used. A relatively stable pattern of stroke occurrence with high registered cases was observed during the study period. It can be concluded that stroke is an endemic disease for the Maputo Central Hospital, with an epidemic pattern during the first semester of 2019. Adoption of 3rd quartile threshold methods for stroke surveillance might well add value for the control of the stroke epidemics.
Knowledge of reproductive age women on prevention of mother to child transmission of human immunodeficiency virus and associated factors at Mecha district, Northwest Ethiopia: A community based cross sectional study
Authors: liyeh Tewachew Muche , Cherkose Endeshaw Admasu , Limenih Miteku Andualem , Yimer Tigist Seid , Tebeje Hailemariam Demewozu
Published: August 2019

Objective: To asses knowledge of reproductive age women on prevention of mother to child transmission of HIV and associated factors at Mecha district, North West Ethiopia, 2016. Result: About 22.4% of the respondents were knowledgeable on prevention of mother to child transmission (PMTCT) of HIV. Having knowledge on PMTCT of HIV was significantly associated with urban residence (AOR =2.486, 95%CI= 1.160-5.328), education level of secondary and above (AOR =5.445, 95%CI=2.698-10.986), those having history of antenatal care followup (AOR =4.430, 95%CI=1.471-13.340), those with history of institutional delivery (AOR=4.766, 95%CI = 2.004-11.334), those having comprehensive knowledge on HIV/AIDS (AOR=1.697, 95%CI = 1.011-2.846), women who were knowledgeable about mother to child transmission of HIV (AOR =2.203, 95% CI =1.37-3.54), and women who held discussions with their husband regarding HIV/AIDS, (AOR= 2.700, 95%CI =1.658-4.396).
Efficacy of a complex intervention comprising the guideline evidence-based health information and a training programme on the quality of health information: study protocol of a randomised controlled trial
Authors: Lühnen Julia , Berger-Höger Birte , Haastert Burkhard , Hinneburg Jana , Kasper Jürgen , Steckelberg Anke
Published: August 2019

Background
Evidence-based health information (EBHI) is a prerequisite for informed and shared decision-making. The criteria for EBHI have been described comprehensively but the implementation in practice is still insufficient. The guideline evidence-based health information addresses providers of health information. Its goal is to improve the quality of health information. The evidence-based guideline emerged from the German Network for Evidence-based Medicine (DNEbM) and was published in February 2017. In addition, the competences of providers of health information were explored and a training programme was developed.
Aim of this study is to evaluate the efficacy of an intervention comprising the guideline evidence-based health information and a training programme addressing providers of health information in a randomised controlled trial. We expect the intervention to improve the quality of health information in comparison to provision of the guideline only.
Methods
The trial uses a superiority randomised control group design with ten months follow-up. 26 providers of health information (groups with up to ten members) will be enrolled to compare the intervention (guideline & training programme) with usual care (guideline publicly available). The 5-day training programme comprises an evidence-based medicine training module and a module to prepare the application of the guideline. The primary outcome measure is the quality of the health information. Quality is operationalised as the extent of adherence to the guideline’s recommendations. Each provider will prepare a single health information informing a health-related decision. The quality of this information will be rated using the MAPPIN Health Information Quality instrument. An accompanying process evaluation will then be conducted.
Discussion
The study results will show whether the efficacy of the intervention justifies implementation of the training programme to enhance health information developers’ competences in evidence-based medicine and to ensure high quality EBHI in the long-term.
Trial registration ISRCTN registry, registration number: ISRCTN96941060, Date: 7 March 2019, URL: http://www.isrctn.com/ISRCTN96941060 Keywords
health information; guideline implementation, training programme; evidence-based medicine; guideline evidence-based health information
Clinical characteristics, risk factors, prognosis and immune status of secondary infection of sepsis: a retrospective observational study
Authors: Chen Yao , Hu Yanyan , Zhang Jin , Shen Yue , Huang Junling , Yin Jun , Wang Ping , Fan Ying , Wang Jianli , Lu Su , Yang Yilin , Yan Lei , Li Keyong , Song Zhenju , Tong Chaoyang , Du Shilin
Published: August 2019

Background: Secondary infection has a higher incidence in septic patients and affects clinical outcomes. This study aims to investigate the clinical characteristics, risk factors, prognosis and immune status of secondary infection of sepsis.

Methods: A four-year retrospective study was carried out in Zhongshan Hospital, Fudan University, enrolling septic patients admitted between January, 2014 and January, 2018. Clinical data were acquired from medical records. CD14+ monocyte human leukocyte antigen-D related (HLA-DR) expression and serum cytokines levels were measured by flow cytometry and enzyme-linked immunosorbent assay (ELISA) respectively.

Results: A total of 297 septic patients were enrolled, 92 of whom developed 150 cases of secondary infections. Respiratory tract was the most common site of secondary infection (n = 84, 56%) and Acinetobacter baumanii the most commonly isolated pathogen (n = 40, 31%). Urinary and deep venous catheterization increased the risk of secondary infection development. Lower HLA-DR expression and elevated IL-10 level were found in secondary infection group. The expected prolonged in-hospital stay owing to secondary infection was 4.63 days. Secondary infection was also associated with higher in-hospital, 30-day and 90-day mortality. Kaplan-Meier survival curves and Log-rank test revealed secondary infection group had a worse survival between day 15 and day 90.

Conclusions: Urinary and deep venous catheter indwelling increased the risk of developing secondary infection. Secondary infection influenced outcomes of septic patients and prolonged in-hospital length of stay. Underlying immunosuppression led to a higher tendency to developing secondary infection.
Optical Quality after Posterior Chamber Phakic Implantation of an Intraocular Lens with a Central Hole (V4c Implantable Collamer Lens) under Different Lighting Conditions
Authors: He Tianrui , Zhu Yi , Zhou Jibo
Published: August 2019

Background

The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting conditions by means of the Optical Quality Analysis System™ (OQAS; Visiometrics, Terrassa, Spain).

Methods

This prospective study involved 91 eyes of 46 consecutive patients undergoing implantation of a V4c ICL (15 males and 31 females). The modulation transfer function (MTF) cutoff frequency, Strehl ratio, objective scattering index (OSI), and predicted visual acuities (PVAs; 100%, 20%, and 9%), under different lighting conditions, were measured before and 1 week, 1 month, and 3 months after surgery.

Results

All optical parameters showed significant improvements, at all time points, under dark condition after surgery. We observed no significant changes in PVA 9% at 1 week (P=0.12) or 1 month after surgery (P=0.08) under light condition; but all other postoperative parameters improved significantly. Comparing the two lighting conditions, the OSI decreased more under dark conditions at 1 week (P=0.02), 1 month (P=0.004), and 3 months (P=0.002), but there was no significant difference in any other parameter. In addition, patients were divided into a high myopia group (group H) and a super-high myopia group (group S), the group S improved significantly more than group H in all parameters, under both bright and dark conditions.

Conclusions

V4c ICL implantation improved optical quality under both bright and dark lighting conditions, and had a better ability to reduce the extent of scattering in the dark. Furthermore, group S achieved greater improvement in visual quality, which should be considered by physicians before surgery.
Usefulness of a stool to stabilize dental chairs for cardiopulmonary resuscitation (CPR)
Authors: Awata Norimasa , Hitosugi Takashi , Miki Yoichiro , Tsukamoto Masanori , Kawakubo Yoshifumi , Yokoyama Takeshi
Published: August 2019

Background: Cardiopulmonary resuscitation (CPR) requires immediate start of manual chest compression (MCC) and defibrillation as soon as possible. During dental surgery, CPR could be started in the dental chair considering difficulty to move the patient from the dental chair to the floor. However, all types of dental chairs are not stable for MCC. We previously developed a procedure to stabilize a dental chair by using a stool. EUROPEAN RESUSCITATION COUNCIL (ERC) guideline 2015 adopted our procedure when cardiac arrest during dental surgery. The objective of this study was to verify the efficacy of a stool as a stabilizer in different types of dental chairs.
Methods: Three health care providers participated in this study, and 8 kinds of dental chairs were examined. MCC were performed on a manikin that was laid on the backrest of a dental chair. A stool was placed under the backrest to stabilize the dental chair. The vertical displacement of the backrest by MCC was recorded by a camcorder and measured by millimeter. Next, the vertical displacement of the backrest by MCC were compared between with and without a stool.
Results: In all 8 dental chairs, the method by using a stool significantly reduced the vertical displacements of the backrest by during MCC. The reduction ratio (mean [interquartile range]) varied between nearly 27 [20] and 87 [5] %. In the largest stabilization case, the displacement was 3.5 [0.5] mm with a stool versus 26 [5.5] mm without a stool (p < 0.001).
Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography
Authors: Li Bing , Chen Youxin , Li Donghui
Published: August 2019

Background: To report a case of Purtscher-like retinopathy (PUR) and the optical coherence tomography (OCT) and OCT angiography (OCT-A) findings before and after treatment.

Case presentation: A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal haemorrhage, and Purtscher flecken spread around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because he lacked any traumatic medical history. OCT presented some band-like hyperreflective lesions at the inner nuclear layer, which are indicative of paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction in blood flow signal at the deep retina and choriocapillaris layers with a honeycomb-like hypointense signal pattern. After 3 months of follow-up, OCT revealed resolution of retinal oedema, but PAMM lesions remained visible. Based on OCT-A, the honeycomb-like pattern turned into a homogeneous reduction in blood flow with small patches of hypointense signal areas in the choriocapillaris.

Conclusion: This case presented a new OCT-A sign in PUR with a honeycomb-like hypointense signal at the choriocapillaris layer, indicating the involvement and ischaemia of the choroid during the pathological process.
Evaluation of agronomic traits and assessment of genetic variability in some popular wheat genotypes cultivated in Saudi Arabia
Authors: Al-Otayk Soleman M.
Published: August 2019

The present study was carried out to evaluate agronomic traits and assessment of genetic variability of some wheat genotypes at Qassim region, Saudi Arabia', during 2010/11 and2011/12 seasons. Fourteen wheat genotypes including five bread wheat and nine durum wheat genotypes were evaluated in randomized complete block design with three replications. The genotypes were evaluated for ten different yield contributing characters viz., days to heading, days to maturity, grain filling period, grain filling rate, plant height, number of spikes m-2, kernels spike-1, 1000-kernel weight, grain yield and straw yield. The combined analysis of variance indicated the presence of significant differences between years for most characters. The genotypes exhibited significant variation for all the characters studied indicating considerable amount of variation among genotypes for each character. Maximum coefficient of variation was observed for number of spikes m-2 (17%), while minimum value was found for days to maturity. Four genotypes produced maximum grain yield and statistically similar, out of them two bread wheat genotypes (AC-3 and SD12) and the other two were durum wheat (AC-5 and BS-1). The genotypes AC-3, AC-5 and BS-1 had higher grain yield and stable in performance across seasons. The estimation of phenotypic coefficient of variation in all the traits studied was greater than those of the genotypic coefficient of variation. High heritability estimates (> 0.5) were observed for days to heading, days to maturity, and plant height, while the other characters recorded low to moderate heritability. The high GA % for plant height and days to heading (day) was accompanied by high heritability estimates, which indicated that heritability is mainly due to genetic variance. Comparatively high expected genetic advances were observed for grain yield components such as number of kernels spike-1 and 1000-kernel weight. Grain yield had the low heritability estimate with a relatively intermediate value for expected genetic advance. The results of principle component analysis (PCA) indicated that the superior durum wheat genotypes for grain yield in the two seasons (AC-5 and BS-1) are clustered in group II (Fig. 2). Also, the superior two bread wheat genotypes (AC-3 and SD12) were in group I. Therefore, it could be future breeding program to develop new high yielding genotypes in bread and durum wheat.
Effect of tear/crack on soybean (Glycine max) seed coat, physiological quality and pathology of the seed
Authors: Machado Bruna Ribeiro , Pereira Caio Cesar de Oliveira , Carvalho Élida Priscila Bogéa , Silva Juliana Oliveira da , Mendes Letícia Maria de Oliveira , Lima Milton Luiz da Paz , Silva Jakelinny Martins , Menezes Ivandilson Pessoa Pinto de
Published: August 2019

Seed coat tear is frequently occurs in some soybean cultivars. The impact of seed coat tear on seed physiology and sanitation is uncertain. Our objective was to analyze the physiological and pathological effect of tear on soybean (Glycine max) seed coat. The cultivars NS-8338-IPRO (with high incidence of tear) and NS-6906-IPRO (with low incidence of tear) were used. A tetrazolium test was used to assess the physiological quality of the seed coat before and after storage. The sanitary quality was assessed through the "Blotter Test". For each storage period, we evaluated seeds with 0% coat tear, up to 10%, and above 10%. The experiment was performed in a completely randomized design using the methodologies proposed by RAS. The coat tear on soybean seed positively contributed to the moisture damage affecting the inner part of the seed. Incidences of Fusarium sp. and Aspergillus sp. were frequently observed in torn seeds and in seeds without tear (around 9-10%) but did not interfere with seed quality. The appearance of coat tear on soybean seed is increased by moisture damage and do not serve as a gateway for the fungi to cause damage during seed emergence.
Membidik Potensi Ekonomi Syariah di Lembaga Pendidikan Pondok Pesantren
Authors: Zuhirsyan Muhammad
Published: August 2019

This study aims to explore Islamic economic empowerment in Islamic boarding schools. Various resources in Islamic boarding schools can be empowered as facilities in implementing and developing Islamic economics. This research method uses a phenomenological qualitative approach that is analytical and inductive descriptive. The object of this study uses several modern boarding schools in Medan, Langkat, Deli Serdang and Serdang Bedagai, North Sumatra. The results show that Islamic economic empowerment can be in the form of application in Islamic boarding schools that can be classified in several ways, including sharia economic principles education, contract and sharia economic cooperation, pesantren accounting and sharia accommodation, culinary and halal tourism. While in the form of sharia economic development, Islamic boarding schools as an institution known for its independence can make Islamic boarding schools as a sharia economic assessment laboratory, form a sharia business forum, become an Islamic economics center and inspire sharia-based economic development. This study uses a phenomenological qualitative approach that is descriptive analytical and inductive in nature by digging data to find the basic things of phenomena, reality and experience.Penelitian ini bertujuan untuk menggali pemberdayaan ekonomi syariah di dalam lembaga pendidikan pesantren. Berbagai sumber daya yang ada di dalam pesantren bisa diberdayakan sebagai fasilitas dalam penerapan dan pengembangan ekonomi syariah. Metode penelitian ini menggunakan pendekatan kualitatif fenomologi yang bersifat deskriptif analitis dan induktif. Objek penelitian ini menggunakan beberapa pesantren modern yang berada di Kota Medan, Langkat, Deli Serdang dan Serdang Bedagai, Sumatera Utara. Hasil penelitian menunjukkan Pemberdayaan ekonomi Islam ini bisa dalam bentuk penerapan di dalam pondok pesantren yang dapat diklasifikasi dalam beberapa hal, di antaranya pendidikan prinsip ekonomi syariah, akad dan kerjasama ekonomi syariah, akuntansi pesantren serta penginapan syariah, kuliner dan wisata halal. Sementara dalam bentuk pengembangan ekonomi syariah, pesantren sebagai lembaga yang dikenal dengan kemandiriannya bisa menjadikan pesantren sebagai laboratorium pengkajian ekonomi syariah, membentuk forum bisnis syariah, menjadi islamic ekonomy centre dan inspirator pengembangan ekonomi berbasis syariah. Penelitian ini menggunakan pendekatan kualitatif fenomenologi yang bersifat deskriptif analitis dan induktif dengan menggali data untuk menemukan hal-hal mendasar dari fenomena, realitas maupun pengalaman.
Groundwater contamination characterization using multivariate statistical analysis and geostatistical method
Authors: Chaudhry Akshay Kumar , Kumar Kamal , Alam Mohd. Afaq
Published: August 2019

The aim of the present study is to identify sources of groundwater contamination in Rupnagar district, Punjab, using an integrated approach of exploratory factor analysis (EFA) and ordinary kriging (OK). For this, a 13 physico-chemical parameter data set at 14 sampling locations for a period of over 25 years was assessed. The correlation was statistically examined amongst parameters. A five-factor model is proposed which explains over 89.11% of total groundwater quality variation. Three semi-variogram models, namely exponential, Gaussian, and spherical, fitted well for the data set and are cross-validated using predictive statistics. Spatial variability maps of all the parameters and factor scores are generated and are in good agreement with each other. The variation seen in groundwater quality is mainly due to various hydrogeochemical, anthropogenic, and geogenic processes occurring in the region. Thus, this study indicated that there is need to treat the industrial and municipal wastewater before discharging it (directly/indirectly) into nearby streams and pits and to encourage sustainable agricultural practices to prevent adverse health effects and minimize further environmental degradation in the study region.
Cognitive motives of sports medicine specialists during training at the center of competence development
Authors: Malinauskas Ramualdas Kazemirovich , Pocius Eimantas
Published: August 2019

The purpose of the study is to compare the cognitive motives and the motives of personality development among sports medicine specialists with and without using innovative technologies at the center of competence development. The results showed that the cognitive motives among sports medicine specialists during training with the use of innovative technologies in the center of competence development are higher compared to the motives among sports medicine specialists during training without the use of innovative technologies.
ORIENTAÇÃO PROFISSIONAL QUANTO AO ALEITAMENTO MATERNO: O OLHAR DAS PUÉRPERAS EM UMA MATERNIDADE DE ALTO RISCO NO ESTADO DE SERGIPE
Authors: Santana Stefani Catarina Gois , Mendonça Andreza Carvalho Rabelo , Chaves Jéssica Natália De Oliveira
Published: August 2019

Objetivo: Analisar as ações de promoção, proteção e apoio à prática da amamentação realizada pelos profissionais de saúde, no olhar das puérperas. Métodos: Estudo descritivo e observacional, realizado em uma maternidade de alto risco no município de Aracaju, SE. Resultados: 96% das puérperas realizaram o pré-natal completo e 56,78% não receberam nenhum tipo de orientação. Dentre as orientações recebidas, a mais citada refere-se ao tempo recomendado para a amamentação (12,29%), seguida da importância da amamentação (9,75%). Conclusão: Mesmo com a adesão da maioria das puérperas à realização do pré-natal completo, há ainda uma necessidade de maiores informações, orientações e apoio dos profissionais quanto ao aleitamento materno.Descritores: Orientação profissional; Aleitamento materno; Puerpério.PROFESSIONAL ORIENTATION ON BREASTFEEDING: THE LOOKING OF PUERPERAS IN A MATERNITY OF HIGH RISK IN THE STATE OF SERGIPEObjective: To analyze the actions of promotion, protection and support to the practice of breastfeeding performed by health professionals, in the eyes of puerperal women. Methods: Descriptive and observational study, carried out in a high risk maternity hospital in the city of Aracaju, State of. Results: 96% of the women who completed the full prenatal care and 56.78% received no guidance. Among the received guidelines, the most cited refers to the recommended time for breastfeeding (12.29%), followed by the importance of breastfeeding (9.75%). Conclusion: Even though the majority of postpartum women are adherent to complete prenatal care, there is still a need for more information, guidance and support from professionals regarding breastfeeding.Descriptors: Professional orientation; Breastfeeding; Puerperium.ORIENTACIÓN PROFESIONAL EN EL ALCANCE MATERNO: LA MIRADA DE LAS PUÉRPERAS EN UNA MATERNIDAD DE ALTO RIESGO EN EL ESTADO DE SERGIPEObjetivo: Para analizar las acciones de promoción, protección y apoyo a la práctica de los amamantamiento realizados por la salud, en los ojos de las mujeres puerperales. Métodos: Descriptive and observational study, llevado a cabo en un alto riesgo de maternidad hospital en la ciudad de Aracaju, State of. Resultados: 96% de las mujeres que completó el completo prenatal care y el 56.78% recibido en la guía. En las primeras pautas, el más citado se refería al recomendado para el amamantamiento (12.29%), seguido por la estima del amamantamiento (9.75%). Conclusión: Sin embargo, la mayoría de las mujeres postpartum de las mujeres son adherentes a completar el prenatal care, todavía no es necesario obtener más información, orientación y apoyo de los profesionales que se comprometen a amamantar.Descriptores: Orientación professional; Lactancia materna; Puerperio.
CARACTERÍSTICAS DOS ENFERMEIROS NO ATENDIMENTO PRÉ-HOSPITALAR: CONCEPÇÕES SOBRE A FORMAÇÃO E EXERCÍCIO PROFISSIONAL
Authors: De Andrade Thamires Faria , Silva Mônica Maria De Jesus
Published: August 2019

Objetivo: analisar as características dos enfermeiros no Atendimento Pré-Hospitalar, sua formação profissional e dificuldades no exercício da profissão. Metodologia: estudo descritivo-exploratório, realizado com sete enfermeiros, por meio de uma entrevista estruturada, no Serviço de Atendimento Móvel de Urgência de um município do Sul de Minas Gerais, Brasil. Resultados: os enfermeiros são egressos de faculdades privadas; possuem formação específica e encontram dificuldades no exercício profissional. Conclusão: a formação específica não garante a inexistência de dificuldades no exercício profissional no atendimento pré-hospitalar e estas evocam a necessidade de aperfeiçoamento, atualização constante e educação em saúde da população.Palavras-chave: Enfermagem; Enfermagem em emergência; Serviços médicos de emergência.CHARACTERISTICS OF NURSES IN PRE-HOSPITAL CARE: CONCEPTIONS ABOUT PROFESSIONAL TRAINING AND PROFESSIONAL PRACTICEObjective: to analyze the characteristics of nurses working in pre-hospital care, their professional training and difficulties in the exercise of their profession. Methodology: a descriptive-exploratory study, was performed with seven nurses working in the Mobile Emergency Care Service of a city in the South of Minas Gerais, Brazil. Results: nurses are graduates of private colleges; Have specific training and encounter difficulties in their professional practice. Conclusion: the specific training does not guarantee the absence of difficulties in the professional practice in prehospital care and these evocate the need for improvement, constant updating and health education of the populationDescriptors: Nursing; Emergency nursing; Emergency Medical Services.CARACTERÍSTICAS DE LOS ENFERMEROS EM LA ATENCIÓN PRE-HOSPITALAR: CONCEPCIONES SOBRE LA FORMACIÓN Y EL EJERCICIO PROFESIONALObjetivo: analizar las características de los enfermeros que actúan en el Servicio Pre-Hospitalario, su formación profesional y dificultades en el ejercicio de la profesión. Metodología: estudio descriptivo-exploratorio, realizado con siete enfermeros actuantes en el Servicio de Atención Móvil de Urgencia de un municipio del Sur de Minas Gerais, Brasil. Resultados: los enfermeros son egresados de colegios privados; Tienen formación específica y encuentran dificultades en el ejercicio profesional. Conclusión: la formación específica no garantiza la inexistencia de dificultades en el ejercicio profesional en la atención prehospitalaria y éstas evocan la necesidad de perfeccionamiento, actualización constante y educación en salud de la población.Descriptores: Enfermería; Enfermería en emergência; Servicios médicos de emergência.
In Vitro Immunodetection of Prothymosin Alpha in Normal and Pathological Conditions
Authors: Karachaliou Chrysoula-Evangelia , Kalbacher Hubert , Voelter Wolfgang , Tsitsilonis Ourania E. , Livaniou Evangelia
Published: August 2019

Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost
all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known
to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a
biologic response modifier mediating immune responses similar to molecules termed as “alarmins”.
Antibodies and immunochemical techniques for ProTα have played a leading role in the investigation
of the biological role of ProTα, several aspects of which still remain unknown and contributed
to unraveling the diagnostic and therapeutic potential of the polypeptide. This review deals with the
so far reported antibodies along with the related immunodetection methodology for ProTα (immunoassays
as well as immunohistochemical, immunocytological, immunoblotting, and immunoprecipitation
techniques) and its application to biological samples of interest (tissue extracts and sections,
cells, cell lysates and cell culture supernatants, body fluids), in health and disease states. In
this context, literature information is critically discussed, and some concluding remarks are presented.
Leishmaniasis and Autoimmunity in Patient with LPS-Responsive Beige-Like Anchor Protein (LRBA) Deficiency
Authors: Salami Fereshte , Shirkani Afshin , Shahrooei Mohammad , Azizi Gholamreza , Yazdani Reza , Abolhassani Hassan , Aghamohammadi Asghar
Published: August 2019

Background/Objective:

LPS-responsive beige-like anchor protein (LRBA) deficiency is a
combined immunodeficiency and immune dysregulation. The authors present a case report of LPSresponsive
beige-like anchor protein (LRBA) deficiency with the history of autoimmunity, enteropathy
and visceral leishmaniasis. Sirolimus therapy was started for autoimmunity and enteropathy but was
discontinued due to recurrent leishmaniasis. Therefore, a common side-effect of many immunosuppressive
drugs in patients with LRBA deficiency is increased susceptibility to infections.

Methods:

Whole exome sequencing was performed to detect the underlying genetic mutation and
Leishmania DNA was detected by the PCR technique in this patient.

Results:

Whole exome sequencing of the patient reported a homozygous frameshift deletion mutation
in the LRBA gene (NM_006726: exon29: c.4638delC, p. S1546fs). Leishmania DNA PCR was positive
in this case.

Conclusion:

Parasite infections manifestations report in LRBA deficiency. Leishmania infections in
patients with chronic diarrhea and autoimmunity should be considered for immunodeficiency.
Acquisition of Skills in Operative Dentistry Following a Contemporary Technique Skills Course: A Retrospective Study
Authors: Sadid‐Zadeh Ramtin , Arany Hema , Guha Upoma , Haraszthy Violet
Published: August 2019

The aim of this study was to evaluate the impact of a contemporary preclinical technique skills course on early dental student performance in a preclinical operative course. Ivorine teeth prepared for Class I resin restorations by the Classes of 2020 and 2021 in one U.S. dental school were evaluated in this study (N=184). Ivorine teeth were prepared during the first practical exam of the operative dentistry course. Students in the Class of 2021 had been enrolled in a contemporary technique skills course a semester prior to the operative dentistry course, while students in the Class of 2020 were not. The preparations were randomly evaluated by three calibrated and blinded faculty members using magnification loupes, an explorer, and a periodontal probe to evaluate external outline form, internal form, depth, and margin following an established rubric. The results showed that students in the Class of 2021 (who had taken the technique skills course) performed significantly better than students in the Class of 2020 for all criteria evaluated (p<0.05). In this study, incorporation of the preclinical technique skills course improved student performance in the subsequent operative dentistry course.
Dental Students' Exposure to Periodontal and Implant Placement Surgeries in U.S. Dental Schools
Authors: Katsaros Theodoros , Allareddy Veerasathpurush , Elangovan Satheesh
Published: August 2019

The aim of this study was to assess nationwide trends in the exposure of dental students to periodontal and implant surgical procedures and to evaluate the potential factors that influence these clinical experiences. A 19‐item questionnaire was sent to all 64 directors of predoctoral periodontics in U.S. dental schools. In addition to gathering information on the percentage of students who perform surgical periodontics or implant placement procedures in each program, data on student research groups, periodontics residency programs, and periodontics faculty practices were collected. A total of 33 responses were received, for a response rate of 51.5%. Among the responding institutions, 97% and 45.5% allowed dental students to perform periodontal and dental implant placement surgeries, respectively, although only 26.4% and 15.2% of the dental class ended up performing periodontal and dental implant placement surgeries, respectively. Crown lengthening was the most commonly reported (84.8%) periodontal surgical procedure performed by dental students. A negative correlation was found between the presence of a periodontics residency program and dental students' placing dental implants, while the size of the residency program positively correlated with dental students' placing dental implants. Overall, a wide variation in the exposure of dental students to periodontal and dental implant placement surgical experiences was found. Future surveys should assess clinical procedures performed in other special‐ties to gain a broader picture of the experience students are gaining in these areas.
A Pro-Somathropic Formulation with GHR Agonistic and Pro-Thyrogenic Features (Preprint)
Authors: Alkoclar Erdal Can
Published: August 2019

BACKGROUND

A Formulation consisting of 2 Dioscin and 2 Glucopyranoside Derivatives with Simultaneous GHRH Stimulative and T3 mRNA Expression Enhancimg Features.

OBJECTIVE

Anti Aging

METHODS

GH/T3 Optimization

RESULTS

Approved in Vitro

CONCLUSIONS

Endogenous GH and T3 Optimization is the an efficient method for combating age related
Senility and Fatigue Symptoms
Factores que estimulan la actividad de innovación en América Latina: un enfoque VECM
Authors: Gutiérrez Flores Luis , Flores Pérez Jonathan
Published: August 2019

En este documento se exponen los resultados de una investigación que indagó en los factores que incentivan la actividad de innovación en América Latina durante 2006-2017. Metodológicamente, la investigación se apoya en un modelo de corrección de errores (VECM) que estima la relación de equilibro de largo plazo entre las variables. Los resultados sugieren la existencia de una relación de equili- brio positiva y signi cativa. Se concluye que en los países de la región donde predominan actividades económicas con escaso contenido tecnológico es más importante la absorción de tecnología empresarial que el gasto en I+D a nivel empresa.
Análisis de la relación entre el sistema de información y el sistema de control de gestión, para administrar los riesgos empresariales, en una empresa de transporte de carga y de personal
Authors: Chávez Lira Katherine
Published: August 2019

El presente trabajo de investigación está orientado a realizar un análisis de los sistemas de información y sistemas de control de gestión de una empresa, de transporte de carga y personal, de la Cuarta Región, donde se verificará la relación actual que existe entre cada una de las áreas funcionales con los sistemas de información y control implementados por la organización en estudio. Corresponde a una investigación de tipo cualitativa con un alcance comprehensivo, donde la técnica aplicada para la recolección de datos fue la entrevista a dos gerentes y un Jefe de área, de una empresa de Transporte de Carga y Personal, de la ciudad de Salamanca, Cuarta Región de Chile. De los resultados obtenidos en la investigación, se desprende la necesidad de implementar un sistema de información que permita integrar a todas las áreas de la empresa.