bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH SENAM OSTEOPOROSIS TERHADAP KEKUATAN OTOT QUADRICEPS DAN KESEIMBANGAN PADA LANSIA
Authors: Choirunnisa Luthfi , Pudjianto Maskun
Published: March 2023

Latar Belakang; Proses menua hilangnya secara perlahan kemampuan jaringan tubuh dengan penurunan kekuatan kurang lebih 1,5 – 5 % tiap tahunnya. Kekuatan otot tertinggi terjadi pada usia 30 tahun, dan berkurang perlahan sekitar 30 – 40 % pada usia 80 tahun. Penurunan kekuatan otot dapat menganggu keseimbangan tubuh lansia. Gangguan keseimbangan dan penurunan kekuatan otot dapat ditingkatkan melalui senam osteoporosis. Tujuan; Mengetahui adanya pengaruh pemberian senam osteoporosis terhadap peningkatan kekuatan otot quadriceps dan keseimbangan pada lansia di Posyandu Desa Tempukrejo. Metode ; Penelitian ini menggunakan metode Quasi-eksperimen dengan one group pre-test post-test design. Populasi dalam penelitian ini adalah seluruh lansia di Posyandu Desa Tempukrejo. Tehnik pengambilan sampel pada penelitian ini menggunakan purposive sampling. Sampel 25 orang lansia yang menghadiri posyandu lansia dan memenuhi kriteria yang ditetapkan peneliti diberikan pelakuan sebanyak 12 kali dengan dosis latihan 3 kali/minggu (selama 4 minggu), 30 menit. Hasil; Hasil penelitian pengukuran kekuatan otot quadriceps menggunakan uji Wilcoxon diperoleh hasil signifikansi p=0,046 (p<0,05) dan pengukuran keseimbangan menggunakan uji paired sampel test diperoleh hasil signifikansi p=0,043 (p<0,05). Kesimpulan; Adanya pengaruh senam osteoporosis terhadap peningkatan kekuatan otot quadriceps dan keseimbangan pada lansia.
Waves of Globalization, Decolonization and Geopolitical Subjectivity
Authors: Hrabovska Iryna , Hrabovskyi Serhii
Published: March 2023

The authors consider the issues of geopolitical subjectivity of Ukraine in the context of globalization processes, starting from the end of the 18th century. The article proves that each significant stage of globalization (the authors use the conceptual metaphor "wave of globalization"), among others, results in anti-colonial revolutions, the emergence of new states, and the independence of countries conquered by empires. Far not every anti-colonial revolution is connected with the formation and establishment of a new geopolitical subject, however, each testifies to a certain national maturity and subjectivity of the activist of such a revolution. This all applied in the past and applies to Ukraine now.Globalization was not and is not a linear process. It sees "ebbs and flows", sometimes the destruction of the achieved gains and advantages of the global economic and political systems. At the initial stages of globalization, despite the problems caused primarily by Russian imperial rule, Ukrainian society underwent noticeable modernization, but found itself in a situation of "delayed nation-building". Various, sometimes diametrically opposed, globalization projects compete with each other and influence those countries that have not yet acquired political subjectivity on the world stage. According to the authors, during the 20th and 21st centuries, the main plot of world development was the constant struggle between more or less democratic and currently totalitarian globalization projects, which had Ukraine as one of their arenas. The emergence of totalitarian states and corresponding global projects coincided in time with the Ukrainian revolution that began in 1917 and had a significant impact on its course, results, and subsequent events. The authors insist that already at that time, Ukraine had already become an important geopolitical factor, but not yet a subject, although certain Ukrainian forces were already internationally significant figures. Ukraine has become a full-fledged geopolitical subject under the current circumstances, having managed to effectively resist Russian aggression.
Sacred and Architectural Objects of Pereiaslav Skansen: Preservation, Development, Prospects
Authors: Fihurnyi Yurii , Lukashevych Oleksii , Haidaienko Ihor , Vysoven Oksana , Kapitan Larysa
Published: March 2023

The article analyses the preservation, development, and further prospects of the functioning of the sacred and architectural objects of the Pereiaslav open-air museum in the conditions of the full-scale Russian-Ukrainian war and the post-war reconstruction of the Ukrainian state. A review of the history of the construction and operation of church buildings was carried out. Their architectural features are characterised. The circumstances of museification are considered. Particular attention is paid to the peculiarities of the coexistence of museum exhibits and religious buildings and the visitors' perceptions of this phenomenon. It is shown that during the totalitarian era, as a result of the state struggle against religion, a huge number of Ukrainian sacred monuments were destroyed, but thanks to the ascetic activities of museum workers, some of them were saved. It was revealed that M. Sikorskyi, M. Zham, together, not only saved sacred objects from complete destruction, but also restored the previous appearance of monuments, thereby preserving them for the contemporaries and descendants. It has been clarified that what the totalitarian Soviet government could not destroy, now it is trying to destroy the criminal Putin regime, therefore, there is an urgent need to carry out a 3-D recording of all historical, cultural, and artistic monuments in Ukraine, if possible, in order to successfully restore them in the event of possible damage to the original appearance of objects. It has been proven that sacred sights are an important component of the development of cognitive types of tourism. The importance and necessity of including the sacred monuments of the museum and the city of Pereiaslav in tourist routes are argued. Their sacral-tourist potential for the development of excursion-religious tourism is determined. The further effective use of sacred monuments for the further development of the tourist resource is substantiated. The results of the research can be used by museum workers, local self-government bodies, and tour operators to develop and substantiate prospective plans for the optimization, improvement, and development of tourist activities based on the sacred heritage of the museum for its popularisation on the domestic and international market for tourist services.
Laju insiden gagal ASI eksklusif di masyarakat nelayan pada masa pandemi Covid-19
Authors: Santoso Hari , Estuti Wiwit , Anwar M. Choiroel , Sulistiyono Priyo , Rahayu Dewi
Published: March 2023

Exclusive breastfeeding in Indonesia reached 37,3%. The Covid-19 pandemic has threatened to reduce exclusive breastfeeding coverage, which will impact the quality of human resources in the future. This study aims to determine the incidence rate of exclusive breastfeeding failure during the Covid-19 pandemic. Cohort study for nine months. In a fishing village, namely Dadap Village, Juntinyuat, Indramayu, West Java 2020. The population is all babies born during the study period, obtained 58 babies. Risk factor data were collected through interviews with questionnaires through home visits. Home visits were conducted six times during the observation period. The analysis was conducted by calculating the incidence rate using the formula for the number of cases of infants failing exclusive breastfeeding divided by the total number of live births during the observation period. The results showed that the incidence rate of exclusive breastfeeding failure in Dadap Village was 96,6 per 100 live births. Complementary feeding was given in formula milk in the first week (84,5%), even 79,3% of it after birth. Mothers and husbands do not know about exclusive breastfeeding (75,9%). The mother took the initiative to provide early complementary feeding with the support of her husband (63,8%). Mothers experience problems in breastfeeding (87,9%), and mothers cannot cope with the problem. In conclusion, the causes of exclusive breastfeeding failure in fishing villages are low income, low maternal education and knowledge, and lack of husband support.
Resilience Is Key to Overcoming Work Burnout
Authors: Resma Stevent , Prastika Netty Dyan
Published: March 2023

This study aims to determine the relationship between toughness and burnout at PT. X. This research method uses a quantitative approach. The sample of this research is 62 employees of PT. X is selected by using total sampling technique. The data collection method used is the toughness and burnout scale. The data analysis technique used is product moment correlation. The collected data were analyzed with the help of the Statistical Package for Social Science (SPSS) version 26.0 for windows. The results of the analysis of the research data show that the correlation coefficient value of r count = -0.538 with p = 0.000. This shows that there is a significant negative relationship between toughness and burnout among PT. X.Penelitian ini bertujuan untuk mengetahui hubungan antara ketangguhan dengan kelelahan kerja pada karyawan PT. X. Metode penelitian ini menggunakan pendekatan kuantitatif. Sampel penelitian ini adalah 62 karyawan PT. X yang dipilih dengan menggunakan teknik total sampling. Metode pengumpulan data yang digunakan adalah dengan skala ketangguhan dan kelelahan kerja. Teknik analisis data yang digunakan adalah korelasi product moment. Data yang terkumpul dianalisis dengan bantuan program Statistical Package for Social Science (SPSS) versi 26.0 for windows. Hasil analisis data penelitian menunjukkan bahwa diperoleh nilai koefisien korelasi sebesar r hitung = -0,538 dengan p = 0,000. Hal ini menunjukkan bahwa ada hubungan negatif signifikan antara ketangguhan dengan kelelahan kerja pada karyawan PT. X.
SOFTWARE DEFINED RADIO FOR SPACECRAFTS COMMUNICATION LINKS
Authors:   Space Research Institute Russian Academy of Sciences  117997, Moscow, Profsouznay str., 84/32., Kosov A.S. , Roshkov V.S. ,   Space Research Institute Russian Academy of Sciences  117997, Moscow, Profsouznay str., 84/32., Roshkov L.S. ,   Space Research Institute Russian Academy of Sciences  117997, Moscow, Profsouznay str., 84/32., Skulachev D.P. ,   Space Research Institute Russian Academy of Sciences  117997, Moscow, Profsouznay str., 84/32.
Published: March 2023

In the paper the development ways of space communication links based on software define radio (SDR) are considered. Shown the practical realizations of different SDR blocks. The receiver (RX) and the transmitter (TX) graphical programs been developed and related circuits based on commercial components have produced. The transponder circuit has experimentally verified.
The dynamics of incidence of active tuberculosis in children in Bukovina, the impact of the COVID-19 pandemic
Authors: Todoriko L.D.
Published: March 2023

Ukraine remains one of the leaders in the global ranking of morbidity and mortality from tuberculosis (TB) and, according to WHO, ranks 5th in the world and 2nd in Europe according to these indicators.
Objective — to analyze the regional features of the epidemiology of tuberculosis among children in the Chernivtsi region.
Materials and methods. The medical records of all pediatric patients with newly diagnosed TB for the period from January 2020 to December 2022 in the Chernivtsi Regional Clinical TB Dispensary were analyzed. Statistical processing of the data obtained during the research was carried out using the IBM SPSS Statistics v. 26.0 program.
Results and discussion. An analysis of the dynamics by years, when Ukraine was in lockdown due to COVID-19, revealed an increase in the incidence of TB among children under the age of 14 — by 2.7 times compared to 2021 and almost 8 times compared to 2020. 2 cases (25 %) of extrapulmonary tuberculosis, one of which (meningoencephalitis) had an unfavorable prognosis and resulted in death. Indicators of the tuberculosis situation in the Chernivtsi Region in the age group of 15—17 years showed an increase in TB in the percentage ratio of almost 2 times, with an even gender distribution (50 % each) compared to 2020 and 2021.
Conclusions. In Bukovina, for the period from 2020 to 2022, increase in the incidence of tuberculosis among children (almost in 2 times) was registered. In 2022, in 100 % of cases, TB was detected during referral, and in children living in rural areas, the majority were girls (62.5 %). In 87.5 % of cases, the diagnosis was confirmed bacterioscopically, in 50 % of children the presence of contact with a tuberculosis source was determined, in 12.5 % there was no BCG vaccination, in 25 % of children MDR-TB was registered.
Implementasi Kegiatan Pembiasaan Tadarus Al Qur’an Dalam Membentuk Nilai-nilai Karakter Peserta Didik di MTs Negeri 2 Kotamobagu
Authors: Daeng Maya Nurdin
Published: March 2023

Tujuan penelitian ini adalah untuk mengetahui bentuk pembinaan yang dilakukan oleh Badan Komunikasi Pemuda Remaja Masjid Indonesia terhadap remaja masjid Al-Muttaqin, dan untuk mengetahui apa saja kegiatan yang dilakukan BKPRMI sebagai upaya untuk membentuk karakter terhadap Remaja Masjid di Kelurahan Singkil Satu Kota Manado.Jenis penelitian ini menggunakan penelitian kualitatif. Metode pegumpulan data dalam penelitian ini menggunakan observasi, wawancara, dan dokumentasi. Adapun teknik pegelolahan dan analisis datanya melalui tiga tahap yaitu reduksi data, penyajian data, dan penarikan kesimpulan, dan pengujian keabsahan data menggunakan uji kreadibilitas dengan teknik triangulasi.Hasil penelitian ditemukan bahwa BKPRMI Kecamatan Singkil berperan sagat penting dalam membentuk karakter remaja ditengah perkembangan teknologi dan pergaulan bebas. Adapun bentuk pembinaan karakter yang diberikan kepada remaja masjid al-muttaqin dengan melaksanakan program tadzkir keliling setiap minggu di masjid-masjid yang berbeda, merekomendasikan narasumber, atau menjadi fasilitator di diskusi-diskusi bersama remaja dan juga sebagai mc, atau pembawa materi dalam kegiatan yang diadakan, kemudian dengan mengagendakan aksi kemanusiaan dalam hal ini pengumpulan dana korban bencana dilakukan dengan Aksi di jalanan. Dan kegiatan yang dilaksanakan dalam membentuk karakter remaja masjid Al-Muttaqin dilakukan melalui kegiatan tadzkir tiap minggu, kajian ke-Islaman serta peringatan hari besar Islam, pengkaderan dan bakti sosial.
Implementasi Permainan Tradisional Petak Umpet pada Anak Usia Dini di Era Society 5.0
Authors: Muharrahman Muharrahman , Loka Novita , Syarfina Adzhani , Kibtiyah Meriatul , Sari Novita
Published: March 2023

Di era society 5.0, permainan tradisional petak umpet sudah mulai hilang dan sangat sulit ditemukan. Saat ini anak-anak lebih menyukai permainan modern yang ada di gadget. Bertujuan untuk mengetahui apakah permainan ini masih digunakan atau tidak dengan zaman teknologi sekarang ini. Penelitian ini merupakan penelitian deskriptif kualitatif dengan pengumpulan data berupa observasi dan wawancara melalui google form dengan 30 responden. Hasil penelitian menunjukkan bahwa permainan tradisional petak umpet masih digunakan oleh anak-anak pada usia dini. Seperti hasil wawancara bahwa 96,7% responden mengatakan permainan ini sudah mulai hilang dengan hadirnya gadget. Solusi dari permasalahan tersebut adalah dengan terus mensosialisasikan permainan tradisional khususnya petak umpet pada anak usia dini. agar warisan budaya yang diturunkan dari generasi ke generasi ini tidak hilang ditelan zaman
Bercerita dengan Boneka Tangan untuk Meningkatkan Empati Anak 4-6 Tahun
Authors: Salim Rose Mini Agoes , Gavinta Dias Amartiwi Putri , Rumalutur Nur Aisyah
Published: March 2023

Anak-anak yang berperilaku agresif cenderung memiliki empati yang rendah sebab kurang memahami dan peduli pada orang lain. Penelitian ini bertujuan untuk mengetahui efektivitas bercerita dengan boneka tangan dalam meningkatkan empati pada anak usia 4-6 tahun. Penelitian melibatkan 11 TPA di Bekasi. Intervensi bercerita menggunakan boneka tangan dengan empat skrip cerita selama empat hari. Cerita disusun berdasarkan aspek ESC dan keseharian anak serta menggunakan boneka tangan rancangan sendiri yang merupakan keterbaruan penelitian. Pengukuran empati menggunakan Empathy Scale for Children (ESC), berupa 12 kartu bergambar dengan cerita singkat yang terdiri dari emosi senang, sedih, marah, dan takut. Analisis data menggunakan uji beda Wilcoxon signed-rank test yang menunjukkan perbedaan nilai rata-rata empati yang signifikan (p 0.05) antara sebelum dan sesudah intervensi. Post-test kedua yang dilakukan dua minggu setelah intervensi tetap menunjukkan peningkatan skor empati yang signifikan. Hal ini memperlihatkan bercerita dengan boneka tangan efektif meningkatkan empati anak usia 4-6 tahun
Zahrawain: Strategi Program Hafalan Al-Qur’an Anak Usia Dini
Authors: Kholis Maisah , Elmubarok Zaim , Setiawan Deni
Published: March 2023

Zahrawain merupakan salah satu metode menghafal al-Qur’an anak usia dini. Metode ini menekankan pentingnya mengoptimalkan indera audio dan visual anak saat menghafalkan al-Qur’an. Penelitian ini bertujuan untuk melakukan eksperimen penerapan program hafalan al-Qur’an anak usia dini menggunakan strategi Zahrawain. Metode yang digunakan adalah eksperimen model Single Subject Research dengan satu sampel dalam desain A-B-A’. Pengumpulan data menggunakan teknik observasi, wawancara, tes dan dokumentasi. Hasil penelitian adalah subjek sebelum adanya perlakuan menunjukkan belum sama sekali menghafal ayat yang akan diberikan, kegiatan menghafal al-Qur’an dengan strategi Zahrawain efektif untuk meningkatkan program hafalan al-Qur’an anak usia dini; dan kondisi subjek setelah diberikan perlakuan menunjukkan pada kategori baik. Secara umum dapat disimpulkan bahwa Zahrawain dalam program hafalan al-Qur’an untuk anak usia dini cukup efektif diterapkan.
Pengembangan E-Modul Literasi Sains Anak Usia Dini
Authors: Sativa Bebyi Riza , Eliza Delfi
Published: March 2023

Literasi sains perlu dikenalkan sejak dini karena penting untuk melatih perkembangan konsep dan perilaku ilmiah. Hasil PISA Indonesia tahun 2018 menyebutkan penurunan literasi paling banyak ditunjukkan pada literasi membaca 371, literasi matematika 379, dan disusul literasi sains 396. Studi tersebut melaporkan bahwa media yang digunakan masih sangat minim sehingga pembelajaran literasi sains tidak optimal. Oleh karena itu, penelitian ini bertujuan untuk menghasilkan e-modul untuk meningkatkan kemampuan literasi sains anak usia dini. Metode yang digunakan adalah pengembangan yang diadopsi dari Borg Gall. Instrumen yang digunakan berupa angket dan pedoman observasi. Subyek yang terlibat adalah tiga guru dan anak usia dini berusia 5-6 tahun yang berjumlah 15 orang. Analisis data dilakukan dengan metode persentase. Hasil analisis data ini dalam penelitian ini dapat dijabarkan berdasarkan perumusan dan pengelolaan pada pengumpulan data, perencanaan, pengembangan draft produk, dan uji coba dan revisi hasil uji coba. Implikasi hasil penelitian ini dapat digunakan oleh guru untuk memberikan kegiatan yang beragam dan menantang terutama berkaitan dengan sains
Marketing Management of Educational Services in Early Childhood Education
Authors: Sulistyorini Sulistyorini
Published: March 2023

The number of PAUD institutions has increased very significantly. This makes each institution have to compete and devise a strategy to win the hearts of parents of prospective students. This study aims to analyze the marketing strategy of educational services carried out by PAUD institutions to parents of prospective students. The research used a descriptive qualitative approach, the researchers conducted observations and interviews with teachers, parents, and community leaders in 3 PAUD institutions in Tulungagung Regency. The respondents in this study were selected using a purposive sampling technique based on the criteria set by the researcher. The results of the study show that PAUD institutions are aware of the urgency of marketing management. Various elements such as teachers, student guardians and stakeholders synergize in marketing educational services. Among the implications of this research is the importance of resources in educational institutions having the ability to manage the marketing of educational services. This ability will increase competitiveness, sustainability of institutions and the quality of graduates.
The Influence of Practical Lecturer Competence and Innovation on Improving Soft Skills and Hard Skills in Early Children
Authors: Djatmika Gatot Herry
Published: March 2023

The purpose of this study was to determine the relationship and influence between the competence of practical educators and the abilities and knowledge of early childhood in soft skills and hard skills. Problems or difficulties arise when learning does not always run smoothly, including a poor school environment, unattractive learning models and reduced early childhood abilities. This situation is often a problem that often arises in the learning process. Teaching and learning has many objectives to be achieved, including the development and improvement of student performance and skills. The method used is quantitative validation. The target of this study were students from several state early childhood education schools in DKI Jakarta Province with a total of 285 students, and the number of children selected using the purposive sampling method was 165 children. The results of the study show that there is a positive and significant relationship between the competence of practicing teachers and young children (soft skills and hard skills). Practical teacher innovation greatly influences the development of early childhood skills. Meanwhile, the competence and innovation of practicing teachers have a positive and significant effect on improving early childhood skills (soft and hard skills). Based on these findings, schools need to maintain children's achievements and develop children's skills in a sustainable manner by providing experienced and trained teachers
Mengoptimalkan Pembentukan Karakter untuk Anak Usia Dini
Authors: Lilianti Lilianti , Rohmiati Rohmiati , Adam Adam , Hermanto Hermanto , Risnajayanti Risnajayanti , Salma Sitti
Published: March 2023

Karakter tidak hanya dibentuk untuk mengejar kecerdasan akademik saja, namun dibentuk untuk kebutuhan anak di masa yang akan datang. Penelitian ini dilakukan untuk mengetahui peran yang diterapkan pendidik dalam membangun karakter siswa. Pendekatan kualitatif digunakan pada kegiatan penelitian ini dengan melibatkan informan sebanyak 5 orang guru. Cara mengumpulkan data dilakukan melalui wawancara, observasi dan dokumentasi. Kemudian peneliti mereduksi data dengan cara membuat rangkuman serta memilih data yang dapat menjawab tujuan penelitian. Tahap selanjutnya  menyajikan data dalam bentuk matriks dan digabungkan dengan informasi yang sudah tersusun agar mudah dicapai, kemudian disimpulkan dan divalidasi. Hasil dari penelitian ini ditemukan bahwa karakter yang dibentuk di sekolah dilakukan melalui peran-peran yang telah diterapkan oleh guru pada saat proses pembelajaran.  Setelah itu, sekolah melibatkan para orang tua siswa untuk mengawasi anaknya ketika berada di rumah. Akan tetapi dalam hal ini yang menjadi faktor penentu adalah kerjasama antara kedua bela pihak.
Study of climatic stability of polyethylene based electrically conductive materials for fuel canisters in North and Arctic coditions
Authors:   Federal Research Centre «Yakutsk Scientific Centre», RAS, SB, Institute of Oil and Gas Problems RAS, Petukhova E.S. , Fedorov A.L. , Argunova A.G.
Published: March 2023

The study results of the impact of weathering factors on the properties of electrically conductive materials based on polyethylene, which are intended for fuel canisters, are presented. These canisters are used to transport fuel to the Northern and Arctic regions of the Republic of Sakha (Yakutia). In this study, samples were exposed to natural weather conditions for 2 years. It is shown that the developed material has the necessary climatic resistance, and its volumetric electrical resistivity decreases, which is due to the occurrence of relaxation processes in its volume.
Endometrial implantation failure in cycles of in vitro fertilization in patients with chronic endometritis
Authors:   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia, Tral T.G. ,   St. Petersburg State Pediatric Medical University of the Ministry of Health of Russia, Saint Petersburg, Russia, Tolibova G.Kh. ,   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia,   I.I. Mechnikov North-Western State Medical University of the Ministry of Health of Russia, Saint Petersburg, Russia, Kogan I.Yu. ,   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia
Published: March 2023

Introduction. Chronic endometritis is one of the most frequent gynecological diseases which negatively impacts the main pathogenetic links in the morphogenesis of secretory and gestational endometrial transformation. These links determine implantation failure. The study aimed to verify the expression of estrogen receptors (ER) and progesterone receptors (PR), progesterone-induced blocking factor (PIBF) and stromal cell-derived factor-1 (SDF-1) in the endometrium of patients having chronic endometritis with ineffective IVF cycles or undeveloped pregnancies occurred after assisted reproductive technologies in their histories. Materials and methods. We formed 3 study groups: group I included samples of the endometrium of patients with ineffective IVF cycles (n=50); group II contained samples received from patients with a history of undeveloped pregnancy after IVF (n=50); and group III (the control group) included endometrial tissue from healthy patients (n=25). We carried out routine histological evaluation followed by an immunohistochemical assay with ER, PR, PIBF, and SDF-1 in the endometrial glands and stroma in the middle secretion phase. esults. The middle stage of the secretion phase of the menstrual cycle in endometrial samples of groups I and II was detected in only 46% and 42% of cases, respectively. We showed a decrease in the ER and PR expression in more than 92% of cases. Statistically significant decrease was detected in PIBF and SDF-1 expression in the endometrial glands and stroma within the implantation window in patients with a history of reproductive loss. Conclusion. Violation of implantation viability with an imbalance of chemokines, cytokines, cellular factors, and structural and functional characteristics of the endometrium was found in patients with revealed chronic endometritis and history of ineffective IVF cycles and miscarriage after ART. Keywords: endometrium,IVF, missed abortion after IVF, estrogen receptor, progesterone receptor, progesterone-induced blocking factor, stromal cell-derived factor-1
Role of HPV and Epstein–Barr virus in the development of epithelial breast tumors
Authors:   Primorsky Regional Oncological Center, Vladivostok, Russia, Lagureva A.V. ,   Pacific State Medical University of the Ministry of Health of Russia,Vladivostok, Russia, Plekhova N.G. ,   Pacific State Medical University of the Ministry of Health of Russia,Vladivostok, Russia, Apanasevich V.I. ,   Pacific State Medical University of the Ministry of Health of Russia,Vladivostok, Russia
Published: March 2023

Breast cancer is the leading cause of oncological morbidity in women worldwide, but its causes are still being investigated. The researchers hypothesized a possible association between breast cancer and viral infection. Some studies support this assumption, while others point out their inconclusiveness. The aim of the review was to study the association of human papillomavirus (HPV) and Epstein–Barr (EBV) infection in breast tumors. We analyzed the results of more than 100 publications demonstrating the relation between HPV and EBV infections and breast tumors of different origin. Data on the presence of viral particles were obtained by various methods: IHC, real-time PCR, and in situ hybridization, where formalin-fixed tissues were studied. We detected HPV and EBV DNA and studied the expression of HPV oncoproteins (E6, L1) and EBV latent antigens (EBNA-1, EBNA-2, EBNA-3, LMP-1). The analysis of more than 4,000 cases of benign and malignant breast tumors indicates a wide range of HPV and EBV prevalence in breast tissue (up to 86% and 56%, respectively). Despite the revealed relations between the presence of viral particles in tissues and the subsequent tumor development, the etiological role of HPV and EBV in the occurrence and progression of breast tumors remains debatable. Keywords: breast tumor, breast cancer, human papillomavirus (HPV), Epstein–Barr virus (EBV), oncoviruses
The evaluation of hibernating myocardium function
Authors:   M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia, Popov M.A. , Shumakov D.V. ,   M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia, Gurevich L.E. ,   M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia, Fedorov D.N. ,   Petrovsky National Research Centre of Surgery, Moscow, Russia, Zybin D.I. ,   M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia, Ashevskaya V.E. ,   MEDSI Group of Companies JSC, Moscow, Russia, Korosteleva P.A. ,   International Network of Clinical Diagnostic Laboratories CITILAB, Moscow, Russia, Tyurina V.M. ,   M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia
Published: March 2023

Introduction.Currently, there are different approaches to assessing changes that occur in ischemic myocardium in patients with chronic coronary artery disease (CAD). Researchers argue about the timing and completeness of the restoration of myocardial dysfunction areas. We aimed to assess hibernating myocardium in the zones of hypokinesia in patients with CAD. Materials and methods. We performed a morphological and immunohistochemical study of left ventricular myocardial biopsies of 25 patients who underwent surgical reconstruction of the left ventricle with surgical revascularization. Results. Morphological and immunohistochemical studies revealed violated morphological structure of cardiomyocytes. It correlates with the accumulation of MMP9 in the cytoplasm of cardiomyocytes in the areas of affected myocardium in ischemia against the background of partial or complete destruction of CM basement membranes formed by type IV collagen. It also correlates with long-term consequences of treatment. Conclusion. As a result of the destructed structure of sarcomeres and cardiac basement membrane hibernating myocardium is unable to provide a contractile function in the future. Morphological examination showed that viable cells were likely to function only as a protective mechanism in early scar formation. Keywords: left ventricular remodeling, hibernating myocardium, basement membrane, cardiomyocytes, matrix metalloproteinase 9, type IV collagen
ОСОБЛИВОСТІ ДИСТАНЦІЙНОГО НАВЧАННЯ АНГЛІЙСЬКОЇ МОВИ ДЛЯ ПЕРСОНАЛУ ЄВРОПЕЙСЬКИХ ПРИКОРДОННИХ ВІДОМСТВ З ВИКОРИСТАННЯМ МЕТОДІВ ФАСИЛІТАЦІЇ
Authors: Ісламова Олександра
Published: March 2023

У статті досліджено особливості дистанційного навчання англійської мови для персоналу європейських прикордонних відомств, для сприяння інтеграції передових ідей у систему дистанційного навчання майбутніх офіцерів-прикордонників у закладі вищої освіти Державної прикордонної служби України, зокрема, надання їм можливості підвищувати рівень іншомовної компетентності у процесі професійної підготовки за дистанційної формою навчання. Відомо, що Державна прикордонна служба України активно співпрацює з європейською агенцією Фронтекс, що дозволяє українським прикордонникам брати участь у міжнародних освітніх проектах, курсах дистанційного навчання загальноєвропейського значення, використовувати електронні навчальні комплекси та підручники, тренажери на основі віртуальної реальності. Розкрито поняття «фасилітація» в освітньому онлайн середовищі, що загалом інтерпретується як сукупність навичок, що використовуються для ефективного управління діяльністю курсантів в мережі Інтернет, що дозволяє виконувати заплановані завдання у мінімальні терміни з максимальним залученням учасників. Висвітлено інноваційні форми та методи навчання, які впроваджуються в навчальний процес, такі як: «Світове кафе», «Поляризація думок», «Модераційні картки», «Континіум», «Акваріум». Узагальнено результати застосування фасилітаційних методів і прийомів під час проведення «Інтенсивного онлайн-курсу англійської мови для прикордонників», що засвідчило ефективність проведеного навчального курсу та вказує на доцільність використання фасилітаційних методів і прийомів у рамках онлайн-курсів навчання майбутніх офіцерів-прикордонників у вітчизняних закладах вищої військової освіти. Відповідно, об’єктивним є сприяння розвитку фасилітаційних навичок тренерів прикордонних закладів освіти на основі передового європейського досвіду.
АНАЛІЗ НАВЧАННЯ ВИБІРКОВОГО МОДУЛЯ «ВЕБ-ТЕХНОЛОГІЇ» У 10-11 КЛАСАХ ЗЗСО
Authors: Яцько Оксана
Published: March 2023

Методична система навчання інформатики, зокрема і вибіркового модулю «Веб-дизайн», як складової предмету «Інформатика» у 10-11 класах ЗЗСО, формулюється як підсистема, функціонування якої визначається певними чинниками. Основними з яких є: соціальне замовлення на сучасному етапі розвитку інформаційного суспільства, інформатичні компетентності, яких має набути здобувач освіти, мета, принципи та зміст навчання та виховання тощо.
Створення та розвиток методичної системи навчання інформатики відіграє ключову роль у становленні шкільною курсу інформатики. Тому актуальним є аналіз елементів методичної системи, виявлення найвужчих місць і проблем, без розв’язання яких неможливий її подальший розвиток.
У статті проведено порівняльний аналіз навчальних програм та підручників з інформатики для учнів 10-11 класів закладів загальної середньої освіти профільного рівня та рівня стандарт; визначено особливості навчання вибіркового модуля "Веб-технології".
Проведений аналіз методики навчання вибіркового модуля «Веб-технології» у 10-11 класах ЗЗСО дозволяє виділити основні моменти побудови уроків, такі як розподіл часу на уроці, побудова самого уроку, розробка практичних завдань тощо. Так виділяється матеріал, який був відомий і його варто повторити, та новий матеріал, що варто опрацювати більш детально.
Role of manganese in the pathophysiology of hepatic encephalopathy: scoping review protocol
Authors: Pérez-Neri Iván , Sandoval Hugo , Malvaso Antonio , Indika Neluwa-Liyanage R. , Alarcon-Ruiz Christoper A. , Ebrahimian Manoochehr , Ríos Camilo
Published: March 2023

Introduction: Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver disease and/or portosystemic blood shunting, characterized by alterations of alertness, personality, cognition, and motor functions. Its severity is defined from mild symptoms to coma according to four grades. This disease may affect several brain regions including the cingulate gyrus, the insular cortex, and the globus pallidus. The pathophysiology of HE is thought to be multifactorial and involves manganese accumulation in the brain, damaging effect of ammonia on glial cells, etc. Previous studies describe the pathophysiology of HE or the effect of manganese in the central nervous system but there is no review addressing both topics from an integrative perspective and using a systematic methodology. This scoping review aims to evaluate the role of manganese in HE. Methods: Published studies (all publication types) will be retrieved from Web of Science, MEDLINE, Scopus, EBSCOhost, Ovid, and Google Scholar. Inclusion criteria are: studies reporting manganese levels in any biological sample or tissue of patients with HE, any experimental model reporting the effect of manganese administration on measures of neuroprotection in models of liver damage, or showing an effect on manganese levels in the liver and/or the brain. Exclusion criteria are: studies reporting subjects exposed occupationally or environmentally to manganese, or written in languages different than Spanish or English that could not be appropriately translated, or whose full-text files could not be retrieved. Either clinical or preclinical studies will be analyzed separately but might be discussed together. Data summaries will be presented in graphs, figures, and tables. A narrative synthesis will be presented. This protocol complies with PRISMA-P.
Overlooked Colotis phisadia (Godart, 1819) (Lepidoptera: Pieridae) – a new record for the butterfly fauna of Kuwait with remarks on host plant
Authors: Marafi Mohammad A.J. , Asadalla Naseraldeen
Published: March 2023

We document a new contribution to the Kuwaiti butterfly fauna: Colotis phisadia (Godart, 1819) was observed for the first time in 2012. This species is confirmed as a new record based on collections and observations made in 2019–2022. The geographic distribution of the
species suggests that the butterfly was relatively recently introduced to the country. Causal evidence behind the introduction of C. phisadia following host plant (Salvadora persica L.) usage in Kuwait is discussed. The butterfly occurred in five localities belonging to four
governorates. Future study of this species in Kuwait is suggested.
On the Afrotropical species of Myospila (Diptera: Muscidae). The first comprehensive identification key to the region's species, and description of a new species
Authors: Zielke Eberhard
Published: March 2023

An identification key to 20 Afrotropical Myospila Rondani, 1856, based on original descriptions and additional information, is provided, including description of a new species from Madagascar, and summary synopses of the other recognised species.
A new species of the genus Doliopteryx Hesse (Diptera: Mythicomyiidae: Glabellulinae) from southern Iran
Authors: Gharali Babak , Moghbeli Sajjad , Evenhuis Neal
Published: March 2023

Two specimens of the genus Doliopteryx Hesse, 1956, were collected from the southern Iran (Kerman province) by white pan trapping and the new species discovered is named Doliopteryx acuminatis sp. n. This new species is easily separated from the two other Iranian species
by its long acuminate first antennal flagellomere. Description and the diagnostic features of Doliopteryx acuminatis sp. n. are presented. A key to species of the genus in Iran is provided.
Zelus renardii (Heteroptera: Reduviidae: Harpactorinae) for Cyprus
Authors: John Eddie , Kolokotronis Demetris
Published: March 2023

We report the discovery of non-native Zelus renardii Kolenati, 1857, (Leafhopper Assassin Bug) new to Cyprus, and discuss the species' known presence in the eastern Mediterranean. As reported elsewhere, arrival is considered to have been human assisted, the early stages passively
carried on imported nursery stock.
X-Girl (part three)
Authors: Akmut Camille
Published: March 2023

"In the transition towards a digital world, women continued to”hack” around laws and morals when it came to their lesbian underground."
Complementary, Alternative, and Integrative Medicine-Specific COVID-19 Misinformation on Social Media: A Scoping Review
Authors: Ng Jeremy Y. , Liu Shawn , Maini Ishana , Pereira Will , Cramer Holger , Moher David
Published: March 2023

Background: The sharing of health-related information has become increasingly popular on social media. Unregulated information sharing has led to the spread of misinformation, especially regarding complementary, alternative, and integrative medicine (CAIM). This scoping review synthesized evidence surrounding the spread of CAIM-related misinformation on social media during the COVID-19 pandemic.Methods: This review was informed by a modified version of the Arksey and O’Malley scoping review framework. AMED, EMBASE, PsycINFO and MEDLINE databases were searched systematically from inception to January 2022. Eligible articles explored COVID-19 misinformation on social media and contained sufficient information on CAIM therapies. Common themes were identified using an inductive thematic analysis approach.Results: Twenty-eight articles were included. The following themes were synthesized: 1) misinformation prompts unsafe and harmful behaviours, 2) misinformation can be separated into different categories, 3) individuals are capable of identifying and refuting CAIM misinformation, 4) non-representative study samples have resulted in considerable generalizability issues, and 5) studies argue governments and social media companies have a responsibility to resolve the spread of COVID-19 misinformation.Conclusions: Misinformation can spread more easily when shared on social media. Our review suggests that misinformation about COVID-19 related to CAIM that is disseminated online contributes to unsafe health behaviours, however, this may be remedied via public education initiatives and stricter media guidelines. The results of this scoping review are crucial to understanding the behavioural impacts of the spread of COVID-19 misinformation about CAIM therapies, and can inform the development of public health policies to mitigate these issues.
Convolutional Neural Network-based Image Denoising for High-Quality Image Reconstruction
Authors: nsim adeil
Published: March 2023

Convolutional Neural Network-based Image Denoising forHigh-Quality Image Reconstruction
Analysis Criminal Offense Law Criminal Case Jiwasraya
Authors: Jones Ithel
Published: March 2023

Default cases committed by well-known and oldest insurance companies, are even known as pioneers in the insurance services industry. The case being discussed involves PT Asuransi Jiwasraya. Problems arise when there are complaints from customers who say that they have not received insurance policy money. The main cause of PT Asuransi Jiwasraya's default is an error in managing the investment in the company. Given these problems, it is necessary to conduct research on the analysis of the Jiwasraya crime from a legal perspective in Indonesia. This study uses a normative juridical method. To support this research by processing data from books and reference studies. Referring to the study of this legal issue, two approaches are used, namely the legal approach and the analytical approach. The purpose of using these two approaches is to find out and analyze basic definitions or definitions, laws, legal systems, regulations, and various draft laws. While this analytical approach is carried out to better understand the definitions and issues related to law and to be able to analyze from a legal point of view more accurately.
When Average Isn't Enough: Identifying Meaningful Subgroups in Clinical Data
Authors: Gloster Andrew , Nadler Matthias , Firsching-Block Victoria Joy , Haller Elisa , Rubel Julian , Benoy Charles , Villanueva Jeanette , Bader Klaus , Walter Marc , Lang Undine , Hofmann Stefan G. , Ciarrochi Joseph , Hayes Steven C.
Published: March 2023

Background: Clinical data are usually analyzed with the assumption that knowledge gathered from group averages applies to the individual. Doing so potentially obscures patients with meaningfully different trajectories of therapeutic change. Needed are “idionomic” methods that first examine idiographic patterns before nomothetic generalizations are made. The objective of this paper is to test whether such an idionomic method leads to different clinical conclusions.Methods: 51 patients completed weekly process measures and symptom severity over a period of eight weeks. Change trajectories were analyzed using a nomothetic approach and an idiographic approach with bottom-up clustering of similar individuals. The outcome was patients’ well-being at post-treatment.Results: Individuals differed in the extent that underlying processes were linked to symptoms. Average trend lines did not represent the intraindividual changes well. The idionomic approach readily identified subgroups of patients that differentially predicted distal outcomes (well-being).Conclusions: Relying exclusively on average results may lead to an oversight of intraindividual pathways. Characterizing data first using idiographic approaches led to more refined conclusions, which is clinically useful, scientifically rigorous, and may help advance individualized psychotherapy approaches.
Fused Deposition Modelling (FDM) and Selective Laser Sintering (SLS) as Indisputable Machines in Additive Manufacturing: A Review
Authors: Erinle Tunji John , Ojaomo Koleola Ebenezer , Adeoye Oluwatosin Samuel
Published: March 2023

The additive manufacturing process is one of the keys to advanced engineering manufacturing processes in this era of the Fourth Industrial Revolution. Fused deposition modelling (FDM) and selective laser sintering (SLS) are two additive manufacturing (AM) techniques that can be used for rapid prototyping. The importance of fused deposition modelling and selective laser sintering as viable equipment for advanced technology development in the manufacturing of interchangeable parts in automotive and aerospace was demonstrated in this review study. The impact of these two machines on the advancement of manufacturing technology is also discussed in this article. The findings demonstrated the enormous benefits of fused deposition modelling and selective laser sintering in the manufacturing industry for efficient and successful production, as well as the duo's applications. The purpose of this paper is to summarise fused deposition modelling and selective laser sintering as important technological tools for advanced manufacturing technology advancement. Many advantages and applications are highlighted in the study, including durability, ease of use, lower production costs, shorter lead times manufacturing process, ease of dealing with complicated cavities and geometries, several high-performance, lower tooling costs, produce customised products, and develop low-volume production, bridge manufacturing, engineering models, testing, and high-temperature applications to bring the product to market quickly.Keywords: Additive Manufacturing, Fused Deposition Modelling, Fourth Industrial Revolution, Rapid Prototyping, Selective Laser Sintering.
Enhancing Image Quality through Convolutional Neural Networkbased Image Denoising
Authors: nsim adeil
Published: March 2023

Enhancing Image Quality through Convolutional Neural Networkbased Image Denoising
Differential expression of GBP6 in cancer of the head and neck: oral squamous cell carcinoma.
Authors: Mamoor Shahan
Published: March 2023

Head and neck cancers are an emerging public health problem and most are now thought to be caused by high-risk human papillomavirus infection (1-3). We mined public and published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with oral squamous cell carcinoma (OSCC). We found significant differential expression of the gene encoding guanylate-binding protein family member 6, GBP6, when comparing OSCC tumor tissue to the tissue of origin. GBP6 mRNA was present at significantly lower quantities in tumors of the head and neck as compared to normal tissues from the head and neck. Analysis of human survival data revealed that expression of GBP6 in head and neck tumors was correlated with overall survival in patients with head and neck cancer. GBP6 expression changes may be important for the initiation or progression of human OSCC.