bluuebunny/crossref_metadata_2025 huggingface dataset:
„Я люблю ездить в г. Челябинск и в Польшу”: Nikolaj Kolada i Polacy – wzajemne fascynacje
Authors: Sadowska Monika
Published: January 2019

Nikolai Kolada’s, by critics called also the “Almodovar of Russian theatre”, artistic work for years is very popular in Poland. This article is an attempt to present the profile of Nikolai Kolada and chosen aspects of his literary output and dramatist’s works reception in Poland. The author also tries to put attention to “father’s of new Russian dramaturgy” cooperation with representatives of Polish theatrical environment and to solve the secret of his popularity in Poland phenomenon.
Frontowik, gławnowierch, opołczeniec, czyli rosyjska terminologia wojskowa w międzywojennej prasie warszawskiej
Authors: Joachmiak-Prażanowska Joanna
Published: January 2019

Russified words concerning army field have been presented in the given article. They were excerpted from “Tygodnik Ilustrowany”. The author explores all annuals of the questioned newspaper, namely the period 1918–1939. She tried to interpret in a semantic way the collected lexical russicisms in respect of their definitions in definitional dictionaries of Polish language, in etymological dictionaries and in other sources. The following topic groups concerning the army were distinguished taking into consideration the noted lexicon, topic groups differing as far as the meaning is concerned: weapon names, military reinforcement, divisions and subdivisions, rank and military occupational specialty, soldiers designation and armies names. Formal and semantic borrowings dominated in the field. Word-formative calques were found on the second place. Semantic calques represented the smallest group.
Kobieta demoniczna Teffi (1872–1952) w przekładzie Juliana Tuwima
Authors: NDiaye Iwona Anna
Published: January 2019

This article deals with the specifics of the language and the translational difficulties of Teffi (Nadezhda Lochwicka), one of the most recognized figures of pre-revolutionary Russia, poet, columnist and author of humorous stories. The author verifies the thesis essence on the material the novel’s title from the collection Demonic woman and her Polish variant in the translation of Julian Tuwim. Evaluating the choice validity of translator equivalents from the standpoint of the author’s individual style, the ideologicaltheatrical and the stylistic aspects were taken into account.
I wojna światowa i sposób jej przedstawienia na przykładzie opowiadania Maksima Hareckiego Litewski chutorek
Authors: Drozd Katarzyna
Published: January 2019

Maksim Harecki introduced the subject of war to Belarusian literature. This story, analysed broadly, shows the consequences of the war for each party in the conflict. This is seen in the construction of the story, based on contrast and the diversified language of the narrative.
Obrazy (z) Arkadii. Jewreinowa sceniczne wspomnienia o Rosji
Authors: Gracla Jadwiga
Published: January 2019

In this article, the author analyzes selected aspects of two dramas of Evreinov from the émigré period: What has no name and Citizens of the second category. One of the principles of constructing their theatrical space is, in the author’s opinion, the principle of memories, which takes place on the stage, transferring the world remembered to the universe of theater. Thus understood, the dramas become not only a testimony to Evreinov’s interest in the transformation of the theater but there is also the unusual testimony of his journal, an album of photographs. Images from the past are kept in these photos, but at the same time they are a warning against rejecting the present, because, as the author shows, such a world can only exist in the theater. The paintings are doubly processed: through memory and through the theater.
Tytuły filmów „oskarowych” w wielojęzycznym przekładzie
Authors: Mocarz-Kleindienst Maria
Published: January 2019

This article provides a comparative analysis of translation strategies for the English titles of Oscar-winning movies (Academy Award for Best Picture) into Polish, German and Russian. The titles analyzed show two strategies: adaptation and exotisation. However, they did not show a clear connection between the translation strategy and the degree of linguistic similarity since there was no clear dominance of exotisation in the German versions, considered to be the closest to the original. A significant use of explication of the meaning of the title in German versions was observed, which may indicate an attempt to more accurately convey basic information about a foreign movie to a German viewer.
Z historii polskich przekładów powieści Doktor Żywago Borysa Pasternaka (na podstawie korespondencji Jerzego Giedroycia i Gustawa Herlinga-Grudzińskiego oraz Jerzego Stempowskiego i Marii Dąbrowskiej)
Authors: NDiaye Iwona Anna
Published: January 2019

This article recalls the circumstances of the first edition of the novel by Boris Pasternak, Doctor Zhivago, in Polish translation, which appeared in 1959 in volume XLIV of the Biblioteka ‟Kultury” series, published by the Paris Literary Institute. Reconstruction of the history of this publishing initiative in the context of the political situation is possible thanks to historical sources preserved in the Paris and Warsaw archives, publications in periodicals, memoirs and epistolary culture. The circumstances in which the typescript was imported to Poland and in which the Literary Institute obtained a license for a Polish translation, the choice of translator, and Jerzy Giedroyc and Gustaw Herling-Grudziński’s correspondence are discussed. An important source of information is the lively correspondence between Maria Dąbrowska and Jerzy Stempowski, the son of a publicist and social activist, and Mason Stanisław Stempowski, a longtime life partner of the writer. The fragments of epistolary culture discussed here allow a better understanding of these outstanding individuals of the twentieth century. The content of the correspondence analyzed also allows us to reconstruct many interesting facts from the field of translating Russian literature into Polish, as well as the complex situation of Polish-Russian relations in the post-war period.
Transformacja mitu o bohaterstwie w rosyjskiej współczesnej prozie wojennej
Authors: Borkowska Aldona
Published: January 2019

Contemporary “war prose” contains works on both the Second World War and the subsequent conflicts in Afghanistan and Chechnya. The aim of the article is to analyse the changes of the war hero myth in autobiographical texts of the wars’ participants. Among the authors are Oleg Yermakov, Zachar Prilepin, Arkady Babchenko. As we find out, the contemporary “war narrative” is interwoven with the lack of ideology and patriotic pathos. A soldier fails to accept his war; moreover, he questions the authorities in their decision to break out the military conflict. In these conditions, it is difficult to make heroic acts and sacrifice for the good of the homeland.
Metafora synestezyjna w rosyjskich tekstach krytyki muzycznej
Authors: Dzienisiewicz Maria
Published: January 2019

The paper presents a variety of synesthetic metaphors used by musical critics. The metaphors were retrieved from musical critical texts written in Russian, which described classical music events. The basis of division are human senses: hearing, touch, sight and taste. Metaphors are divided into two main groups: intermodal and singlemodal ones. The most representative type turned out to be synesthetic metaphors referring to the sense of touch.
Leksykalne wykładniki wybranych emocji negatywnych w rosyjskojęzycznej wersji utworu Katarzyny Grocholi Upoważnienie do szczęścia
Authors: Rudyk Anna
Published: January 2019

The subject of the analysis in this article are words that describe negative emotions of sadness, anger and fear: nouns, verbs, adjectives and adverbs containing the following roots: -smut-, -zł- and -strach-. The source of the factual material is the book by Katarzyna Grochola Upoważnienie do szczęścia and its translation into Russian. The collected factual material includes a total of 42 examples of sentences with lexemes with the meaning of sadness, anger and fear, containing the aforementioned roots and includes 9 exponents of sadness, 10 – of anger and 23 examples in which the emotion of fear is named. The syntax roles of the analysed lexemes and their Russian text equivalents are usually convergent in the sentences of both languages, which results from the fact that the lexemes are in most cases translated by means of dictionary equivalents, retaining the morphological identity.
Językowe emanacje emocji w Listach do Voli Vładzimira Naklajeva jako źródło wartościowania rzeczywistości
Authors: Sitarski Andrzej
Published: January 2019

On the basis of the analysis of the letters of Vladimir Naklajev to his wife, Vola, the author concludes that the linguistic forms used in the letters serve the function of conceptualisation of the emotions of their author. In fact, they are an example of ego-documents that represent the self-perception and interpretation of a particular political event in Minsk in 2010, through which the Belarussian poet, Vladimir Naklajev, verbalises his personal accounts of himself, events and other people linked with these events in the Belarussian capital. It is worth pinpointing that the language of the letters has a specific emotional climate that changes in accordance with events, situations and people, to which their author refers. The properties of the linguistic code of the letters allow to understand them as texts that symbolise the personal senses of their author.
PREVENTION OF MYELOSUPPRESSION BY COMBINED TREATMENT WITH ENTEROSORBENT AND GRANULOCYTE COLONY-STIMULATING FACTOR
Authors: Shevchuk O O , Posokhova K A , Todor I , Lukianova N Yu , Nikolaev V G , Chekhun V F
Published: January 2019

Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colonystimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. Still, no trial was performed to combine both of them. Aim: To study the influence of combination of enterosorption and pharmaceutical analogue of naturally occurring G-CSF (filgrastim) on bone marrow protection and the growth of grafted tumor in a case of injection of melphalan (Mel). Materials and Methods: Mel injections were used for promotion of bone marrow suppression in rats. Carbon granulated enterosorbent C2 (IEPOR) was used for providing of enteral sorption detoxifying therapy. Filgrastim was used to increase white blood cells (WBC) count. Results: The simultaneous usage of enterosorption and filgrastim had maximum effectiveness for restoring of all types of blood cells. WBC count was higher by 138.3% compared with the Mel group. The increase of platelets count by 98.5% was also observed. In the group (Mel + C2 + filgrastim) the absolute neutrophils count was twofold higher, in comparison with rats of Mel group. Conclusion: Simultaneous admin istration of G-CSF-analogue and carbonic enterosorbent C2 is a perspective approach for bone marrow protection, when the cytostatic drug melphalan is used. Such combination demonstrates prominent positive impact on restoring of all types of blood cells and had no influence on the antitumor efficacy.
DETECTION OF NOTCH1 c.7544_7545delCT MUTATION IN CHRONIC LYMPHOCYTIC LEUKEMIA USING CONVENTIONAL AND REAL-TIME POLYMERASE CHAIN REACTION
Authors: Bilous N I , Abramenko I V , Chumak A A , Dyagil I S , Martina Z V
Published: January 2019

Aim: To evaluate real-time polymerase chain reaction (PCR) assay system for detection of NOTCH1 c.7541_754delCT mutation in chronic lymphocytic leukemia (CLL) patients. Material and Methods: A total of 325 CLL patients were included in the study. Screening for NOTCH1 c.7544_7545delCT was performed using conventional PCR-based amplification refractory mutation system (ARMS) method. All 33 samples harboring c.7544_7545delCT allele and 5 negative cases as control were submitted to real-time PCR. Results: Specificity and sensitivity of two PCR techniques were comparable. NOTCH1 c.7544_7545delCT mutation was found by ARMS in 10.1% of CLL patients, which is consistent with the data of other studies. However, the results of ARMS PCR in a minority of cases (2.15%) were doubtful and required reinvestigation. Real-time PCR, being less time-consuming, showed advantage in the assessment of the amplification’s specificity (using the melting curve analysis). It also allows the quantitative assessment of NOTCH1-mutated clone. Conclusion: NOTCH1 c.7544_7545delCT mutation resulting in removal of the C-terminal PEST domain, deregulation of NOTCH1-dependent signaling pathways, has negative influence on prognosis of CLL and efficiency of therapy with anti-CD20 monoclonal antibodies. Real-time PCR allows the fast and reliable detection of c.7544_7545delCT mutation and can be used for the screening of this molecular lesion in CLL patients.
EFFECT OF COPULATION ON POTENTIALLY PRECANCEROUS PROSTATE LESIONS, SERUM TESTOSTERONE AND PROLACTIN LEVELS IN RATS
Authors: Herrera-Covarrubias D , Tecamachaltzi-Silvaran M B , Barradas-Moctezuma M , Rosales-Raya J B , Manzo J , García L I , Aranda-Abreu G E , Ismail N , Coria-Avila G A , Hernandez M E
Published: January 2019

The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. Aim: In the present study, we assessed the long­term effects of copulation on the development of precancerous lesions in rats, and compared them with testosterone­induced prostatic lesions. Materials and Methods: One group of Wistar males was given 10 copulatory sessions to one ejaculation with ovariectomized, hormone­primed females. Sessions occurred twice per week for a total of ten trials. A second group was exposed to females during the same trials, but physical contact was prevented. In addition, each group received a subcutaneous implant in the back either filled with testosterone propionate (T, 100 mg/kg) or empty. This resulted in four subgroups: 1) Control + No sex, 2) Control + Sex, 3) T + No sex and 4) T + Sex. Two days after the 10th trial all the males were sacrificed for prostate histo logy (H&E) and hormone analysis (testosterone and prolactin). Results: Males from the group Control + No sex expressed normal histo logy. However, those in the groups Control + Sex and T + No sex expressed metaplasia and dysplasia in both the dorsolateral and ventral portions of the prostate, respectively. Interestingly, males from the group T + Sex expressed dysplasia in the dorsolateral prostate only, but not in the ventral prostate. Conclusions: These results indicate that constant copulation may facilitate the development of prostatic lesions in males with normal levels of testosterone. However, copulation induces less lesions in the ventral prostate of males treated with testosterone.
EFFECTIVENESS OF SODIUM DICHLOROACETATE AGAINST GLIOMA С6 DEPENDS ON ADMINISTRATION SCHEDULE AND DOSAGE
Authors: Fedorchuk A G , Pyaskovskaya O N , Gorbik G V , Prokhorova L V , Kolesnik D L , Solyanik G I
Published: January 2019

Background: Anticancer action of sodium dichloroacetate (DCA) could be related to its ability to activate oxidative phosphorylation leading to enhanced generation of reactive oxygen species and induction of apoptosis. On the other hand, activation of oxidative phosphorylation could promote tumor cell survival, in particular, via increased ATP synthesis. Such ambiguous effects of DCA could influence its anticancer effectiveness, depending on biological properties of a tumor, schedule of DCA administration and its dosage. The aim of the study was to analyze anticancer effect of DCA against glioma С6 in rats under conditions of different schedules of its administration and various dosages. Materials and Methods: The study was carried out in Wistar rats with intracerebrally transplanted glioma С6 cells. Therapy with DCA was performed as follows: daily for 6 days starting from the second day after tumor cell transplantation (schedule І) or 7th day (schedule ІІ) at a dose of 1.0 g/kg, or daily for 13 days starting from the second day at doses of 1.0; 1.5 or 4.5 g/kg (schedule ІІІ). An influence of hypoxia on anticancer effect of DCA was studied using hypoxic chambers where oxygen content was maintained at a level of 12.5–13% for 3 h after DCA administration to glioma С6 bearing rats. The state of mitochondrial electron transport chain components in tumor cells was studied using electron paramagnetic resonance. Results: It has been shown that therapy with DCA using schedule I resulted in 15% decrease of animals life span (LS; р < 0.05), while the use of schedule II had no effect on this index. Prolonged administration of DCA (schedule ІІІ) resulted in significant antitumor effect and increased LS of rats by 25.5% (p < 0.05). Under hypoxic conditions, treatment with DCA resulted in a significant increase of animal LS by 15–22%. Dosage of DCA had a moderate effect of its anticancer action. Maximal effect, an increase of LS by 34.5% (p < 0.05) was detected at a dose of 1.5 g/kg. It has been shown that anticancer activity of DCA under all studied conditions is not related to its influence on a functional state of tumor cell mitochondria. Conclusion: Anticancer effect of DCA significantly depends on a schedule of its administration; being administered at equal total dose, but dependent on the schedule DCA could cause ambiguous effects varying from tumor growth stimulation to significant anticancer activity. Under hypoxic conditions, anticancer efficacy of DCA against glioma С6 is significantly enhanced.
2-DEOXY-D-GLUCOSE ENHANCES DICHLOROACETATE ANTITUMOR ACTION AGAINST LEWIS LUNG CARCINOMA
Authors: Pyaskovskaya O N , Kolesnik D L , Fedorchuk A G , Prochorova I V , Solyanik G I
Published: January 2019

Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. Aim: To study antitumor and antimetastatic activity of the modulators of energetic metabolism dichloroacetate (DCA) and 2-deoxy-D-glucose (2DG) used in combination treatment of Lewis lung carcinoma (LLC). Materials and Methods: As experimental tumor model, LLC/R9 variant was used. DCA and 2DG were administered per os to С57Bl/6 mice 5 times per week for 3 weeks at a total dose of 1.5 and 0.98 g/kg, respectively, as single agents or in combination starting from the following day after tumor cell transplantation. Growth of primary tumor and number and volume of lung metastases were registered. Lactate and pyruvate content was determined by enzymatic methods using lactate dehydrogenase. Electron paramagnetic resonance was used for analyzing the functional state of the components of mitochondrial respiratory chain. Engulfing activity and reactive oxygen species (ROS) production in tumor-associated CD14+ cells was analyzed by flow cytometer with the use of FITC-labeled staphylococcus, and by spectrofluorometry with the use of 2.7-dichlorofluorescein diacetate, respectively. Results: DCA administered as a single agent did not affect primary tumor growth but decreased the number and volume of lung metastases by 60% (p < 0.05) and 90% (p < 0.05), respectively. In mice treated with 2DG only, primary tumor volume as well as the number and volume of lung metastases were not affected. Combination treatment with DCA and 2DG resulted in the decrease of primary tumor volume, the number and volumes of lung metastases by 70; 46, and 90%, respectively (р < 0.05). High antitumor activity of DCA + 2DG was associated with 31% decrease (p < 0.05) of lactate content in tumor tissue and 120% increase (p < 0.01) of ROS production in СD14+ cells recruited to the region of tumor growth. Conclusion: 2DG that possesses neither antitumor nor antimetastatic activity against LLC/R9 significantly enhanced antitumor activity of DCA with accompanying inhibition of glycolysis and increase of cytotoxic activity of CD14+ cells infiltrating tumor tissue. Taking into account significant antimetastatic activity of DCA this substance could be considered as a promising antimetastatic agent.
MOLECULAR MARKERS OF APOPTOSIS IN CANCER PATIENTS EXPOSED TO IONIZING RADIATION: THE POST-CHORNOBYL VIEW
Authors: Philchenkov A A , Balcer-Kubiczek E K
Published: January 2019

During the past three decades, the deleterious consequences of Chornobyl accident including carcinogenic effects in the people who were accidentally exposed to radiation have been intensively studied. In particular, recent studies provided increased knowledge of the molecular pathogenesis of thyroid tumors in children exposed to Chornobyl fallout. The risk of several forms of leukemia including myelodysplastic syndromes is elevated in Chornobyl liquidators. Furthermore, the upward trends of increases in a variety of other tumors including breast cancer, cancers of central nervous system and renal cancer have been reported in the persons exposed to Chornobyl fallout. There is growing evidence that insufficient apoptosis allows irradiated cells to survive and thereby contributes to carcinogenesis. The purpose of the present survey is to summarize the recent findings related to apoptotic biomarkers among cancer patients from the different populations affected by the Chornobyl catastrophe. Among the particularly radiosensitive cancer sites, we focused on thyroid cancer and leukemia. Several genes and/or proteins controlling apoptosis directly or indirectly have been incorporated into the analysis. The data reviewed here provide a mechanistic link between the apoptosis alterations and development of radiation-related cancer in the 30-year post-Chornobyl period. We suggest that the type of mutations arising from misrepair of DNA double strand breaks (gene fusion and amplification) is the initial signature event in radiation-induced thyroid cancer. Much work has to be done over the next years to elucidate central questions related to the nature of human radiation carcinogenesis. This article is part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.
DISORDERED REDOX METABOLISM OF BRAIN CELLS IN RATS EXPOSED TO LOW DOSES OF IONIZING RADIATION OR UHF ELECTROMAGNETIC RADIATION
Authors: Burlaka A P , Druzhyna M O , Vovk A Vovk , Lukin S M
Published: January 2019

Aim: To investigate the changes of redox-state of mammalian brain cells as the critical factor of initiation and formation of radiation damage of biological structures in setting of continuous exposure to low doses of ionizing radiation or fractionated ultra high frequency electromagnetic radiation (UHF EMR) at non-thermal levels. Materials and Methods: The influence of low-intensity ionizing radiation was studied on outbred female rats kept for 1.5 years in the Chernobyl accident zone. The effects of total EMR in the UHF band of non-thermal spectrum were investigated on Wistar rats. The rate of formation of superoxide radicals and the rate of NO synthesis in mitochondria were determined by the EPR. Results: After exposure to ionizing or UHF radiation, the levels of ubisemiquinone in brain tissue of rats decreased by 3 and 1.8 times, respectively. The content of NO-FeS-protein complexes in both groups increased significantly (р < 0.05). In the conditions of ionizing or EMR the rates of superoxide radical generation in electron-transport chain of brain cell mitochondria increased by 1.5- and 2-fold, respectively (р < 0.05). In brain tissue of rats kept in the Chernobyl zone, significant increase of NO content was registered; similar effect was observed in rats treated with UHFR (р < 0.05). Conclusions: The detected changes in the electron transport chain of mitochondria of brain cells upon low-intensity irradiation or UHF EMR cause the metabolic reprogramming of cell mitochondria that increases the rate of superoxide radical generation and nitric oxide, which may initiate the development of neurodegenerative diseases and cancer. This article is part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.
TISSUE-ENGINEERED BONE FOR TREATMENT OF COMBAT RELATED LIMB INJURIES
Authors: Vasyliev R G , Oksymets V M , Rodnichenko A E , Zlatska A V , Gubar O S , Gordiienko I M , Zubov D O
Published: January 2019

Aim: Based on our preliminary positive clinical results with use of cultured bone marrow-derived multipotent mesenchymal stem/stromal cells in traumatology, our aim was to develop living three-dimensional tissue-engineered bone equivalent transplantation technology for restoration of critical sized bone defects caused by combat related high energy trauma. Materials and Methods: To fabricate bone equivalent we used devitalized allogeneic bone scaffolds (blocks and chips) seeded with cultured autologous cells: bone marrow-derived multipotent mesenchymal stem/stromal cells in mix with periosteal progenitor cells and endothelial progenitor cells. Quality/identity of cell cultures was assured by donor and cell culture infection screening (immunofluorescence assay, polymerase chain reaction), flow cytometry (cell phenotype), karyotyping (GTG banding), functional assays (colony forming units analysis, multilineage differentiation assay). Bone defect treatment with bone equivalent application was fully completed in 39 combat-injured with 42 defects. New bone formation was assessed by the radiographic examination. Results: Casualties were included in a treatment program an average of 10.1 months after injury, provided the ineffectiveness of conventional surgery methods. All cell type cultures had a normal karyotype and appropriate phenotype, differentiation potential and functional properties, ~30% colony forming units frequency and hadn’t any signs of cell senescence. The fluorescein diacetate/propidium iodide combined staining and histology analysis of graft samples before transplantation showed their regular seeding with viable cells. Pathomorphological analysis of bone equivalent specimens 3–6 months post-op revealed the active remodeling processes and immature bone tissue formation. Bone defect restoration was observed 5–6 months post-op. Conclusion: The developed biotechnology of living three-dimensional tissue-engineered bone equivalent transplantation with overall effectiveness 90.4% allows restoring the bone integrity, forming new bone tissue in a site of bone defect, and significantly reducing the rehabilitation period of a patient.
ANTI-CANCER EFFICIENCY OF NATURAL KILLER CELLS DIFFERENTIATED FROM HUMAN ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS AND TRANSFECTED WITH miRNA150
Authors: Karlitepe A , Kabadayi H , Vatansever S , Gurdal M , Gunduz C , Ercan G
Published: January 2019

Aim: The aim of this study is to investigate the effects of miR150 transfection on NK-like cells differentiated from adipose tissue derived mesenchymal stem cells (AD-MSCs). Methods: NK-like cells were differentiated from AD-MSCs and activated by miR150 transfection. Transfected/non-transfected NK-like cells were characterized by immunohistochemical and RTPCR analyzes. Apoptotic efficiency of the transfected/non-transfected NK-like cells on pancreatic cancer cells PANC1 were determined by TUNEL and RT-PCR. Results: In miR150-transfected cells, the increased expression of NK cell-specific genes such as GZMB, KIR2DL2, CD16, CD56, NKG2D, NKp46 and increased immunoreactivity of NK cell-specific surface marker CD314 (NKG2D) were evident. TUNEL assays showed that NK-like cells with/without transfection induced apoptosis in PANC1 cells in the same manner. The decrease in oncogene expression and the increase in the tumor suppressor gene expression in PANC1 cells upon co-culture with NK-like cells differentiated from AD-MSCs were more prominent following miRNA150 transfection. Conclusion: It was shown in vitro that NK-like cells could be obtained by differentiation from AD-MSCs and their efficiency could be increased via miR150 transfection. The results are encouraging for further clinical studies in improvement of immunotherapeutic approaches for cancer therapy.
UPAYA MENINGKATKAN 7K DI SEKOLAH MELALUI KEGIATAN REUSE, REDUCE, DAN RECYCLE (3R) DI SMP NEGERI 1 TEGOWANU KABUPATEN GROBOGAN TAHUN PELAJARAN 2010/2011
Authors: . Hartanto
Published: January 2019

Abstrak: Penelitian ini dilandasi oleh sebuah kenyataan bahwa kebersihan di SMP Negeri 1 Tegowanu Kabupaten Grobogan selama ini tidak dapat maksimal. Sampah berserakan di mana-mana. Tempat sampah yang sudah tersedia tidak dapat dimanfaatkan secara maksimal. Kamar mandi/WC siswa terlihat kotor dan bau tidak sedap. Di beberapa lokasi halaman, pekarangan, dan kebun sekolah terlihat kotor karena bekas untuk membakar sampah. Masalah yang diteliti dalam penelitian ini adalah (1) Apakah dengan program kegiatan Reuse, Reduce, dan Recycle (3R) dapat meningkatkan 7K di SMP Negeri 1 Tegowanu, dan (2) seberapa besar peningkatan 7K setelah dilaksanakan program kegiatan Reuse, Reduce, dan Recycle (3R) di SMP Negeri 1 Tegowanu. Sedangkan tujuan penelitian ini adalah (a) untuk memperoleh informasi yang akurat apakah melalui program kegiatan Reuse, Reduce, dan Recycle (3R) dapat meningkatkan 7K di SMP negeri 1 Tegowanu dan (b) untuk memperoleh informasi yang akurat mengenai besarnya peningkatan 7K setelah dilaksanakannya kegiatan program kegiatan Reuse, Reduce, dan Recycle (3R) di SMP Negeri 1 Tegowanu. Desain penelitian ini adalah penelitian tindakan sekolah (PTS). Teori yang dipakai dalam penelitian ini meliputi teori-teori tentang hasil belajar, hal-hal yang mempengaruhi hasil belajar, pengertian 7K, pengertian 3R dalam pengelolaan sampah, penciptaan budaya bersih di sekolah, dan dampak lingkungan sekolah terhadap hasil belajar siswa. Penelitian berlangsung selama dua siklus. Tiap siklus terdiri atas perencanaan, pelaksanaan, observasi, dan refleksi. Data penelitian diperoleh dengan pengamatan dan wawancara. Hasil penelitian ini menunjukkan bahwa melalui kegiatan 3R (Reuse, Reduce, dan Recycle), 7K di SMP Negeri 1 Tegowanu meningkat.
UPAYA MENINGKATKAN HASIL BELAJAR DAN KEAKTIFAN BELAJAR MATEMATIKA MELALUI PENDEKATAN KONTEKSTUAL TEKNIK BERMAIN MENGGUNAKAN KARTU “BILANGAN KUBIK-AKAR PANGKAT TIGA” SISWA KELAS VI SD NEGERI 02 SIDOMULYO TAHUN PELAJARAN 2012/2013
Authors: Nuredi Casto
Published: January 2019

playing by learning bermain untuk belajar. Manusia secara kodrati dikatakan sebagai Homo luden makhluk bermain.Dan memang sehatinya kecenderungan manusia adalah untuk bermain. Kami mencoba untuk mengadakan penelitian tindakan kelas dengan menggunakan cara bermain kartu playing card yaitu kartu edukatif yang didesain sebagai kartu bilangan. Permainan ini menerapkan pembelajaran konstektual sebagai bagian dari Quantum math learning (QML). Penelitian ini bertujuan untuk menentukan besaran peningkatan hasil belajar dan keaktifan belajar peserta didik kelas VI SD Negeri 02 Sidomulyo, kec. Lebakbarang, Kab. Pekalongan pada kompetensi dasar akar pangkat tiga suatu bilangan kubik yang telah mendapat perlakuan pendekatan konstektual learning berorientasi Quantum Math Learning dengan teknik bermain. Skenario pembelajaran dimulai dari konteks kehidupan nyata (daily life) peserta didik yang gemar bermaian. Bermain ini digunakan sebagai sarana pembelajaran. Dengan cara bermain diketahui hasil penelitian bahwa ini dapat meningkatkan minat peserta didik Dalam pembelajaran kompetensi dasar akar pangkat tiga suatu bilangan kubik dan dari hasil tes diperoleh data bahwa nilai rata-rata peserta didik mengalami peningkatan pada kondisi sebelum tindakan yaitu 61,1 persen menjadi 76,8 persen pada siklus I dan 86,6 persen pada siklus II. Hal ini menunjukkan peningkatan yang cukup besar yaitu 15,8 persen pada siklus I dan 25,5 persen pada siklus II. Setelah perbaikan tindakan pada siklus II terjadi peningkatan dari siklus I sebesar 9,7 persen. Nilai tertinggi mengalami peningkatan dari 8 pada siklus I menjadi 10 pada Siklus II. Kata kunci :Pendekatan kontekstual, teknik bermain, kartu kubik, keaktifan belajar
MENINGKATKAN KUALITAS BELAJAR ANAK AUTIS MELALUI BERBASIS METODE ABA (APPLIED BEHAVIOUR ANALYSIS) LOVAAS
Authors: Fatkuroji Tn
Published: January 2019

Kebutuhan belajar anak autis adalah dengan bantuan media visual, tetapi fasilitas multimedia yang dapat mendukung pembelajaran tersebut kurang diperhatikan dan dikembangkan. Akibatnya muncul kesulitan dalam meningkatkan kualitas belajar mereka. Tulisan ini bertujuan mendefinisikan kebutuhan belajar anak autis,dengan Metode ABA Lovaas sesuai kebutuhan belajar anak autis untuk meningkatkan kualitas belajarnya. Untuk memahami karakter anak autis, yang diperlukan antara laina; menggali kebutuhan belajarnya dan penerapan metode ABA Lovaas dalam pembelajaran. Selain itu hal yang tidak kalah penting adalah, bahwa peningkatan kualitas belajar anak autis sangat variatif tergantung spektrum yang dimilikinya, sehingga terjadi perbedaan respon tiap-tiap anak yang sulit digeneralisasikan. Kata Kunci : kualitas belajar, autis, ABA Lovaas.
SAlNS DAN AGAMA DIALOG UNTUK SALING MENGUATKAN
Authors: Fadlan Andi
Published: January 2019

AbstrakAl Qur’an ternyata masih banyak dipahami sebagai firman Tuhan. Sejatinya isi Al qur’an yang menguraikan bukti-bukti kebesaran Allah yang tersingkap di alam semesta belum sepenuhnya terjabarkan dengan observasi, trial and error, atau proses-proses ilmiah lainnya. Namun demikian sains dan agama perlu dipahami dengan baik agar umat Islam tidak mudah digoyahkan oleh pandangan-pandangan anti integrasi, pandangan yang masih menginginkan agar sains dipisahkan jauh dari agama (Islam).  Keberadaan Islamisasi sains cukup menginspirasi dan mendorong manusia untuk memahami Islam lebih mendalam. Begitu pula saintifikasi Islam dapat berperan memberi warna modernitas pada Islam yang terlanjur dicap sebagai agama konservatif. Temuan-temuan sains yang memiliki kebenaran obyektif diharapkan mampu menyampaikan pesan-pesan agama kepada umat Islam guna mencapai kebahagiaan hidupnya.  Melalui sains Islam pula, dialog sains dan Islam akan menjadi lebih jelas dan terarah dengan melihat posisi dan peran yang  sebenarnya.Kata Kunci : Sains, agama, dan dialogAbstract           The Qur'an was still very much understood as God's word. Indeed the content of Al Qur'an that describes the evidence-proof of the greatness of God, is revealed in nature the universe is not completely span the 'hierarchy by observation, trial and error, or a processes more scientific. However, science and religion need to be well understood  that Muslims are not easily swayed by the anti-integration views, the views were still desires that separated science from religion (Islam). The existence of the Islamization of science quite inspire and encourage people to understand Islam more deeply. Similarly, Islam saintifikasi may contribute to  modernity in Islam is already branded as a religious conservative. The findings of science that has the objective truth is expected to convey religious messages to Muslims in order to achieve the happiness of his life. Similarly Islam through science, science dialogue and Islam will become more clear and focused by looking at the actual position and role.Keywords: science, religion, and dialogue
Eksistensi Pendidikan Karakter Peserta Didik dalam Balutan Full Day School
Authors: Imaniyah Alfiyatul
Published: January 2019

AbstrakTulisan ini akan membahas tentang eksistensi pendidikan karakter di sekolah dalam konsep full day school. Sekolah merupakan lembaga yang berperan sebagai penyelenggara pendidikan dan pengembangan ilmu, pengetahuan, teknologi dan seni. Tujuan pendidikan ialah membentuk kepribadian, kemandirian, keterampilan social dan karakter. Oleh sebab itu, berbagai program dirancang dan diimplementasikan untuk mewujudkan tujuan pendidikan tersebut, terutama dalam rangka pembinaan karakter. Full day school akhir-akhir ini yang menjadi kontro versi dikalangan masyarakat pun menempati tempat ternyaman. Dibuktikan dengan menjamurnya sekolah-sekolah yang mulai menerapkan full day school untuk meningkatkan kualitas pendidikan karakter siswa khususnya.Kata kunci : Pendidikan Karakter, Peserta Didik, Full day SchoolAbstractThis writing is presenting about the existence of character education in schools in the concept of full day school. School is an institution that acts as a provider of education and development of science, knowledge, technology and art. The purpose of education is to shape the personality, independence, social skills and character. Therefore, various programs are designed and implemented to realize the purpose of education, especially in the context of character building. Full day school lately which became the contro version of society also occupies the most comfortable place. It is proven by the proliferation of schools that start implementing full day school to improve the quality of character education of students in particular.Keywords: Character Education, Educate Participants, Full day School
Rapid development of computer games in China
Authors: Gao Qiang , Yuan Zhonghu , Xu Xinhe , Hao Lina , Cao Ruimin
Published: January 2019

Thousands of years ago, Go and Chinese chess were popular board games in China. The words “Chuhe Hanjie” that is often printed on Chinese chess game boards to divide the two player sides is a reference to the Chu-Han war; while it is far from proof that Chinese chess dates back to the Han dynasty, there is much evidence to show that the game has a long history. Computer game tournaments began comparatively late in China, but they have developed very quickly. This article summarizes the history of the development of computer game tournaments in China and discusses the reasons for the rapid development of computer game tournaments in China from several perspectives. Finally, we comment on the future of computer game tournaments in China.
Real-World Outcome of 173 Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC) Cases: The Experience of the Center Group for Genitourinary Tumors
Authors: Martín Almudena , Puente Javier , Pinto Alvaro , Gajate Pablo , Gordoa Teresa Alonso , Grande Enrique , Herrero Ana , Maximiano Constanza , Garrido María , Gallegos Isabel , Villalobos Ma Laura , García-Donas Jesús , Caviedes Edinson , García Iciar , Espinosa Javier , Aguado Carlos , Arranz José Angel , García Lourdes , Rodriguez Juan Francisco , Casinello Javier , Rodriguez Laura
Published: January 2019

Non-clear cell renal cell carcinoma (nccRCC) represents a group of multiple histologic subtypes, with different clinical outcomes and an uncertain optimal treatment. Data collected in clear cell tumors are routinely extrapolated to nccRCC, despite a different underlying biology. The Center Group for Genitourinary tumors is a network of medical oncologists from hospitals in Madrid and surrounding provinces that are focused on genitourinary tumors. A retrospective, multicenter study of the outcome of patients with nccRCC diagnosed and treated at the Center Group hospitals between 1995 and 2015 was performed. Baseline clinical features, histologic subtypes, therapeutic management and survival status were analyzed. Data was collected from 173 patients, with a median age at diagnosis of 65 years [24–90], 67.1% were male. Histologic subtypes comprised 55.5% papillary carcinoma, 23.1% sarcomatoid, 13.9% chromophobe, 6.9% unclassified tumors and 0.6% oncocytoma. 159 patients received first line therapy including tyrosine kinase inhibitors (67.9%) and mammalian target of rapamycin inhibitors (11.9%). The response rates (RR) in evaluable patients (142) were: complete response 5.6%, partial response 17.6%, stable disease 40.8% and progression in 35.9% of cases. 90 patients (52.0%) received second line treatment. At the time of the data cut-off point (April 1, 2016), 126 patients had died, with a median overall survival (OS) of 17.9 months [95% CI 15.0–20.9]. The clinical outcome reported in this study has a similar OS to other published studies. Nevertheless, there are substantial differences among the distinct subtypes. Overall, prognosis in nccRCC remains poor. No significant differences were observed in the activity of systemic agents, used as either first or second line therapy.
Characteristics and resistance to selected disinfectants of bacterial spores of Bacillus subtilis and Bacillus cereus
Authors: Kierzkowska Anna Kinga
Published: January 2019

Despite the emergence of newer disinfectant preparations on the market, there are still no biocides that would effectively eliminate spores of multi-drug resistant pathogenic bacteria. For this reason, most commercially available sporicidal preparations are mixtures of several substances. The paper discusses the endospore characteristics, their development cycle and the list of currently effective substances used in mixtures of sporicidal preparations
Characteristics of humoral response in individual IgG subclasses in the course of selected bacterial infections in humans
Authors: Rastawicki Waldemar
Published: January 2019

It has been recognized that human serum IgG is composed of four distinct subclasses. The IgG subclasses differ not only in their distribution in normal serum, but also in their biological properties and the nature of the antigens which elicit their production. In general, bacterial proteins antigens preferentially induce IgG1 antibodies in humans, with minor contributions of IgG3 and IgG4. In contrast, IgG response to polysaccharides is normally restricted to the IgG2 subclass, although some polysaccharides also induce substantial amounts of IgG1.
Dehydration, Rehydration, and Hyponatremia
Authors: Lamarine Roland J.
Published: January 2019

Current health culture suggests that sedentary individuals should be consuming at least eight, eight ounce glasses of water each day. This injunction further stipulates that the water requirement cannot be adequately met by consumption of sweetened, caffeinated, or alcohol containing fluids. An additional concern is that thirst may not serve as an adequate early indicator of hydration needs. These propositions are reviewed in light of current research findings and suggestions are submitted for appropriate emendation of these rules.
Prevalence and Predictors of Fruit Intake Among Community College Women in the Extended Opportunity Program and Services
Authors: Shive Steve E. , Neyman Michelle R.
Published: January 2019

This study examined fruit intake among 276 female Extended Opportunity Program and Services (EOPS) community college students. Knowledge, attitudes, and behaviors associated with fruit intake were determined. The attitudes which are potential predictors of daily fruit intake were also examined. Analysis showed that 33% ate fewer than the minimum recommended two daily servings of fruit. Students reported that fruit gave them energy, taste and cost were not barriers to consumption and that it would not be difficult to increase daily fruit consumption. A linear regression analysis revealed that beliefs that eating fruit leads to good health, having a habit of eating fruit, feeling energy, and weight loss accounted for 30% of the variance in fruit intake.
Hemophobia In High School Students, Guntur, Andhra Pradesh, India
Authors: Pitchaiah Podila Sankara
Published: January 2019

Hemophobia fear of blood, is a type of specific phobia. The present study was aimed to know the Hemophobia among 8th to 10th studying students in rural and urban Government schools. The response was taken from 3399 students (8th:1175, 9th:1095, 10th:1129). The study found that the phobia was more in Namburu school students (21.31%). In the urban schools the highest percentage was noticed in SJRR school (28.96). Homeopathy, Exposure based therapy, Cognitive therapy are some of the useful treatment methods. Parents shall not neglect any specific phobia, which can influence the future.
Plano de Empreendimento: LOJA DE ROUPAS E ARTIGOS INFANTIS
Authors: Mendes Fabiana da Conceição
Published: January 2019

Através da observação direta do empreendedor no mercado de Itaipuaçu, município de Maricá/RJ, foi identificada uma demanda por um estabelecimento que oferte produtos infantis. Dessa forma, realizou-se este plano para abertura de uma loja de roupas e artigos infantis. A empresa busca atender ao público local, no que tange a produtos infantis, classe média, com faixa etária de usuários de 0 a 14 anos. Visa ofertar produtos de qualidade, excelência no atendimento e bom preço. Os principais objetivos são: Atender as necessidades dos clientes com roupas e acessórios, calçados, brinquedos, higiene pessoal e cosméticos, utilidades, passeios e enxoval; E ser líder do ramo no comércio local, sendo reconhecida como uma loja atrativa que supre as expectativas dos clientes. Em termos de faturamento, nos 3 anos iniciais de sua existência, a empresa espera pagar seus custos e despesas, recuperar o investimento inicial e começar a ter lucro. Para concretizar o Plano de Negócios, com vistas à locação do imóvel, adequação, legalização e aquisições tanto para composição da loja, quanto de suprimentos para comercializar, presume-se a necessidade de um investimento aproximado de R$100.000,00 (cem mil reais).
Plano de Empreendimento: CASA DE MÚSICA
Authors: De Freitas Thiago Fonseca
Published: January 2019

A Casa de Música se propõe a ser uma produtora musical com infraestrutura completa de estúdio, escritórios e ambiente multiuso utilizado como restaurante e espaço para eventos.  Com essa infraestrutura diferenciada, pretende atender às necessidades dos clientes, que sentem falta de conveniências agregadas aos serviços musicais nos principais estúdios e produtoras do mercado. O mercado musical vem apresentando crescimento nos últimos anos, e é atualmente caracterizado por mudanças de comportamento dos produtores e consumidores de música, em decorrência de novas tecnologias. Pela diversificação dos serviços prestados, o público alvo pode ser dividido nas seguintes categorias: Estúdio musical; Produtora musical; Incubadora de bandas; Aulas de música e Bar e Restaurante.
Plano de Empreendimento: CANTINHO DA GLADYS
Authors: Guimarães De Oliveira Marcia Gladys
Published: January 2019

Trata-se de um projeto de uma loja voltada para a venda de bolos saudáveis, chamada Cantinho da Gladys, na Zona Norte da cidade de Rio de Janeiro – RJ, que será situada no bairro Tijuca. A loja de bolos Cantinho da Gladys possui valores bem destacados em relação à qualidade, tanto dos produtos oferecidos como do atendimento ao público. A oportunidade de negócio existe pelo fato das pessoas buscarem uma vida mais saudável ou se preocuparem cada vez mais com a saúde, uma vez que a taxa de pessoas diabéticas, celíacas e intolerantes à lactose crescem ano a ano.  Diferente de outras lojas que vendem bolos e doces tradicionais, muitas vezes menos acessíveis e que deixam muito a desejar na qualidade, nossa loja terá uma menor variedade de produtos, até por ser um empreendimento ainda em crescimento, e nosso foco principal será manter a qualidade de nossos bolos saudáveis, para que correspondam as expectativas de nossos clientes.  Acreditamos que a qualidade, seja no serviço ou no produto, é a chave para o sucesso, uma vez que diminui a chance de erros. Pretendemos constantemente medir a satisfação dos nossos clientes em relação a nossa empresa. Focaremos também em um atendimento de excelência e funcionaremos de segunda a domingo, ampliando a possibilidade de captação de novos clientes e fidelização dos atuais. Será necessário um investimento pré-operacional de R$ 35.466,00 para a inauguração do Cantinho da Gladys. A receita mensal da estimativa de vendas conservadora, no primeiro ano, será de R$ 227.160,56 e o custo dos produtos e serviços de R$ 127.967,27, o que gera uma margem de contribuição de R$ 96.014,63. No entanto, o saldo do fluxo de caixa no primeiro ano ainda será negativo, o que demandará recursos adicionais para o giro do negócio.  O tempo para a recuperação do investimento (payback) será de aproximadamente trinta e dois meses, levando em conta uma projeção de receitas conservadora e um nível de crescimento orgânico para o empreendimento. Mas vale destacar que a partir do terceiro ano os resultados do empreendimento são satisfatórios. E com a marca estabalecida no mercado será possível realizar expansões, com abertura de novas unidades ou adoção de um sistema de franquias.