bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Hukum Perikatan Islam Terhadap Kerjasama Periklanan Google Adsense Pada Youtube
Authors: Nurseha Muhammad Achid , Hakim Muhammad Fajrul
Published: February 2023

The purpose of this study is to find out how the mechanism of Google Adsense advertising cooperation on Youtube and whether the mechanism is in accordance with Islamic law of engagement. This research is Library Research with a qualitative approach.  The data collecting techniques are using the study of literatures, documents, Google's official website  while to strengthen the data used interviews with Content Creators. The results of this study indicates that the Google Adsense advertising cooperation mechanism involves three parties, namely the Advertiser as the first party, Google as the second party and Content Creator as the third party. Advertisers ask Google for services to advertise their products and Google cooperates  with Content Creators to serve ads. Advertiser pays to Google according to the agreement and Google will share the results with the Content Creator according to applicable regulations. The contract used from the perspective of Islamic law is called an ijarah agreement between the Advertiser and Google and a syirkah contract between Google and the Content Creator. In the course of the transaction or cooperation, it reflects the value of Islamic engagement law, both from contracts, transactions and reflects the value of principles in Islamic engagement law.
Manajemen Keputusan Berisiko
Authors: Achyar M. Munir , Sahputra Refaldy Barry , F Wildan Rizki , Maulana Indra , Pangkio Senggi , Kurniasari Puji , Satria Wisnu
Published: February 2023

An organization or company cannot be separated from the activity of managing risk. Management must decide how to manage economic resources according to the goals of the organization or company. Risk is a hazard or a threat or possibility of an action or event that has an impact which is contrary to the objectives to be achieved. The method used in this research is descriptive analysis with a qualitative approach where this approach describes research on a subject. Sources of data are secondary data obtained through library research in the form of journals, news articles, and books related to research. The data that has been collected will be classified, then verified whether it is in accordance with the research and then analyzed. The results of the study found that a leader must be brave in making decisions because the determination of decision making greatly affects the achievement of organizational goals and also an action to solve problems.
Determinan Penggunaan E-Wallet Generasi Milenial Muslim
Authors: Aisyah Aisyah , Nurohman Yulfan Arif , Qurniawati Rina Sari
Published: February 2023

Perkembangan teknologi informasi memberikan kemajuan dalam bidang keuangan terutama pembayaran digital. Pada saat ini pembayaran digital menjadi sebuah kebutuhan untuk mendapatkan beberapa akses yang ditawarkan kepada masyarakat. Tujuan penelitian ini untuk menguji faktor-faktor yang menentukan generasi milenial untuk menggunakan e-wallet. Adapun variabel yang diuji meliputi persepsi kegunaan, persepsi kemanfaatan, persepsi risiko, dan persepsi keamanan. Responden pada penelitian ini ialah generasi milenial muslim yang berada di kawasan Solo Raya. Berdasarkan hasil pencarian data diperoleh sampel sejumlah 108 responden yang berada dikawasan Solo Raya. Teknik pemilihan responden menggunakan purposive sampling yang memberikan kriteria tertentu kepada sampel. Adapun metode penelitian yang dilakukan merupakan penelitian deskriptif analisis linear berganda. Pengujian yang dilakukan menggunakan software SPSS dengan melakukan pengujian validitas dan reliabilitas sebelum melakukan regresi berganda untuk pembuktian hipotesis. Berdasarkan data yang diperoleh menunjukan responden terbanyak didominasi oleh perempuan, adapun pekerjaan yang terbanyak ialah karyawan swasta. Hasil pengujian variabel menunjukan bahwa persepsi kegunaan dan persepsi kemanfaatan memiliki pengaruh positif terhadap keputusan penggunaan bagi generasi milenial muslim. Adapun variabel persepsi risiko dan keamanan tidak berpengaruh terhadap keputusan penggunaan e-wallet.
Komodifikasi Agama: Sebuah Strategi Pemasaran
Authors: Kholida Maya , Rodiah Ita
Published: February 2023

Globalisasi memberikan pengaruh yang sangat luas termasuk dalam pergesaran yang terjadi pada sektor industri di era globalisasi. Setidaknya terdapat dua fenomena pergeseran dalam sektor indistri saat ini, yaitu fenomena pergeseran dari permasalahan produksi ke konsumsi, dan pergeseran fokus kapitalisme dari pengeksploitasian pekerja ke pengeksploitasian konsumen. Indonesia sebagai negara mayoritas muslim menjadikan muslim market ladang eksploitasi konsumen yang sangat menjanjikan bagi kaum kapitalis. Kaum kapitalis memanfaatkan agama islam sebagai komoditas untuk menggapai keuntungan maksimal dalam mengeksploitasi konsumen muslim. Pada awalnya agama bukanlah sesuatu yang bersiafat komoditi oleh kaum kapitalis dijadikan layaknya barang komoditi yang akan mendatangkan banyak keuntungan. Tulisan ini mengkaji tentang fenomena yang terjadi di masyarakat mengenai adanya komodifikasi agama islam. Tujuan penelitian ini yaitu untuk mengkaji fenomena komodifikasi agama Islam di Indoensia sebagai sebuah strategi pemesaran dengan target muslim market. Metode yang digunakan dalam penelitan ini adalah tinjauan pustaka atau literatur review, yaitu dengan meninjau serta mengkaji secara kritis temuan, gagasan, atau pengetahuan dalam literatur. Hasil dari penelian ini di Indonesia komodifikasi agama Islam mutlak terjadi, dan merupakan strategi pemasaran yang banyak dilakukan oleh pelaku usaha.
Why Are Incretin-Based Therapies More Efficient in East Asians? Perspectives from the Pathophysiology of Type 2 Diabetes and East Asian Dietary Habits
Authors: Yabe Daisuke , Kuwata Hitoshi , Iwasaki Masahiro , Seino Yutaka
Published: February 2023

Type 2 diabetes mellitus (T2D) is one of the most serious global health problems. This is partly a result of its drastic increase in East Asia, which now comprises more than a quarter of the global diabetes population. Ethnicity and lifestyle factors are two determinants in the aetiology of T2D, and changes such as increased animal fat intake and decreased physical activity link readily to T2D in East Asians, which is characterised primarily by β-cell dysfunction that is evident immediately after ingestion of glucose or a meal, and less adiposity compared with T2D in Caucasians. These pathophysiological differences have an important impact on therapeutic approaches. Incretin-based therapies, such as dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide-1 receptor agonists (GLP-1RA), have become widely available for the management of T2D. Incretins, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1 are secreted from the gut in response to the ingestion of various nutrients, including carbohydrates, proteins, and fats, and enhance insulin secretion via a glucose-dependent pathway to exert their glucose-lowering effects. Recent meta-analyses of clinical trials of DPP-4i and GLP-1RA found the drugs to be more effective in East Asians, most likely due to amelioration of the primary β-cell dysfunction by increased stimulation through incretin activity. In addition, our finding that the glycosylated haemoglobin-lowering effects of DPP-4i are enhanced by fish intake, and possibly worsened by animal fat intake, suggests that dietary habits such as eating more fish and less meat can affect the secretion of incretins, and supports the greater efficacy of incretin-based therapies in East Asians.
Homozygosity For The C282Y Substitution In The HFE Gene: The Incomplete Penetrance And Variable Expressivity
Authors: Ekanayake Dilum , Roddick Clinton , Khanbhai Murtaza , Powell Lawrie W.
Published: February 2023

The syndrome of hepatic cirrhosis diabetes and skin pigmentation (‘Bronze diabetes’) has been well documented, including its propensity to lead to hepatocellular cancer. However, this picture of advanced disease is much less common nowadays with increased awareness and early diagnosis. However, in addition to this, it has been increasingly recognised that in contrast to other diseases inherited as autosomal recessive traits, subjects carrying the genetic predisposition infrequently develop overt disease. This is due only in part to physiological and pathological blood loss, and further relevant genetic mutations have been anticipated. Indeed, an international consortium has recently identified that the genetic variant ( GNPAT ) has been identified as predisposing to iron overload related disease. Further mutations can be anticipated and will assist in early diagnosis and treatment as well as identifying subjects predisposed to significant iron overload.
Discourse Network Analysis (DNA): Aktivisme Digital dalam Perdebatan Isu “Presiden Tiga Periode” di Twitter
Authors: Khatami Muhammad Iqbal
Published: February 2023

Artikel ini menawarkan Discourse Network Analysis (DNA) tentang bagaimana pola komunikasi aktivisme digital dalam perdebatan publik pada isu “Presiden Tiga Periode”. Data diambil dari capture tweet di Media Sosial Twitter dengan kata kunci “Presiden Tiga Periode” dan mendapat total 2606 Tweet dan Komentar dengan pengambilan data sumber dari tanggal 16 hingga 24 September 2021.  Pemrosesan data yang dihasilkan berupa diagram akun dengan references tertinggi, diagram indikator isu perdebatan, sociogram, dan data wordcloud. Hasil penelitian ini menunjukkan akun yang terlibat dalam perdebatan didominasi oleh akun tanpa identitas dan memiliki pengikut yang sangat banyak hingga ratusan ribu. Peta perdebatan utama dalam isu ini bukan pada pro dan kontra, namun pada saling konter narasi. Pihak pendukung pemerintah menganggap isu ini adalah permainan oposisi, dan pihak oposisi menarasikan bahwa ini merupakan rencana pemerintahan saat ini untuk mewacanakan jabatan presiden tiga periode melalui amandemen UUD 1945. Implikasi dan kontribusi dari penelitian ini adalah menggambarkan bagaimana keterkaitan antar wacana dilihat dari aktor yang terlibat, akun yang disebut, tagar yang digunakan hingga persebaran tweet yang dilihat dari sociogram.
Authenticity Within Oatly’s Reaction to the Communication Crisis
Authors: Kuncoro Atika Rusy
Published: February 2023

In exploring how people make sense of Oatly’s crisis reaction and its authenticity, this study employed qualitative research analysis. Engaged to symbolic interaction theory, situational crisis communication theory and authenticity, data from interviews with Oatly consumers were investigated to collect pattern and meaning to further extract the key themes. Taken place in Oatly original base in Sweden, this research argues that the way consumer see authenticity in a brand’s action is based on their own preferred concept. Three themes regarding how consumer make sense of Oatly’s reaction to the crisis were concluded. Moreover, three themes emerged during analysis regarding to how consumer understand authenticity in a crisis response.
Pengaruh Terpaan Tayangan Video YouTube Otodriver.com Terhadap Asosiasi Merek Mobil Pada Pengikut Akun
Authors: Prabowo Dhimas Luthfi , Salim Mufid , Hariyanti Nunik , Marta Rustono Farady
Published: February 2023

Seiring berkembangnya zaman, semakin banyak masyarakat yang mengandalkan perolehan informasi melalui sarana internet atau media online. Media online sendiri memiliki peran sangat penting dalam penyebaran informasi. Otodriver.com merupakan portal berita di internet khusus membahas mengenai otomotif. Berawal dari website www.otodriver.com lalu melebarkan sayap ke kanal YouTube dan menyajikan konten audio visual yang berisi tentang informasi mengenai kendaraan roda empat terbaru yang diulas secara lengkap oleh para ahli secara independen. Penelitian ini dilakukan untuk mengetahui apakah terdapat pengaruh terpaan tayang video YouTube Otodriver.com terhadap asosiasi merek mobil terhadap pengikut akun. Metode penelitian yang dilakukan adalah kuantitatif eksplanatif dengan purposive sampling terhadap 100 orang pengikut akun. Hasil dari penelitian ini menunjukkan terdapat 64,7% pengaruh terpaaan tayang dengan asosiasi merek mobil pengikut akun. Asosiasi merek merupakan pengalaman untuk mengidentifikasikan identitas pembeda antara suatu barang atau jasa lainnya.
Mental Health Promotion Efforts in the Switch-Up Program in Collaboration with the Indonesian Mental Health Foundation (YSMI)
Authors: Robaeni Tiara Pascanoviera , Hafiar Hanny
Published: February 2023

Mental health problems can be handled by promoting mental health to the community, as was done in the Switch-Up program in collaboration with the Indonesian Mental Health Foundation (YSMI). The activities carried out are expected to build awareness about the importance of maintaining mental health and the need to be treated if affected by mental health disorders. Departing from the conceptual basis of health promotion and the theoretical basis of symbolic interaction, the researcher obtained a typification as the purpose of this study was to find out how mental health promotion efforts were carried out by the Switch-Up program in collaboration with YSMI. The basic procedure used is qualitative approach, constructivism paradigm, case study type by collecting data through observation, in-depth interview with purposive sampling technique, documentation and literature study. The data analysis and data validity test by data triangulation. The results of this study, the Switch-Up program activity with YSMI on its part made activities that contained providing education about mental health through various activities, mental health check-ups and know your strength. integrated health services from promotive, preventive, rehabilitative and curative efforts. In addition, with YSMI's collaboration, the participants and clients have a stronger belief because it brings out the figure of Dr. Rama Giovani SpKJ as the icon of the Switch-Up program and the treatment process for mental health problems can be followed up both in terms of consultations to medicines by more professionals in their fields. In conclusion, mental health promotion needs to be implemented in an integrated manner so that the fulfillment of needs in dealing with mental health problems can be met.
Public Satisfaction with The Performance of The Government of Joko Widodo – Jusuf Kalla
Authors: Bakheet Hamed Norallah
Published: February 2023

AbstractOne of the parameters of leadership success is the public's satisfaction with the performance. The pair of President and Vice President Joko Widodo - Jusuf Kalla who led Indonesia in 2014-2019 also did not escape this assessment. Public voices can be used as an evaluation of the government that has been carried out for the future to formulate policies that can protect and side with the people. Based on this, the purpose of the research was to determine the extent of the public's response to the performance of the Jokowi-JK government, as well as which sectors were considered good or not by the public. This research uses mixed methods with a descriptive approach. The theory used is the concept of Governments, Performance Theory, Political Communication, and Community Satisfaction. Primary data was obtained using a questionnaire distribution technique to respondents, with a simple random sampling technique. Meanwhile, secondary data were obtained through literature studies relevant to this topic. The results showed that the economic and law enforcement sectors had a low level of satisfaction with Jokowi-JK's performance, namely 30% and 40%, respectively. Meanwhile, the social welfare sector and the political and security sector have a high level of satisfaction at 80%.
On The Elementary and Numerical Approach to k-tuple Conjecture
Authors: Mahmud Salman
Published: February 2023

In 1922 Hardy and Littlewood proposed a conjecture on the asymptotic density of admissible prime k-tuples. Here we have used a sieve method and shown an elementary process to calculate the approximate number of admissible prime k-tuples and compared with Hardy-Littlewood conjecture and real values. Then we have combined our elementary formula with the results obtained from numerical data of real values and generated a new formula which gives almost same results as Hardy-Littlewood conjecture. We have also proposed an easy form of this conjecture which gives us a new perspective to think about it.
Structural informality and occupational classes in a peripheral context: precariousness and in-work poverty in Argentina 2003 – 2020.
Authors: Pla Jésica Lorena , Poy Santiago , Salvia Agustín
Published: February 2023

The aim of this article is to relate the tradition of studies on socio-occupational classes with the perspective of structural informality. Taking Argentina as a case study, it examines the way in which occupational class inequality and job quality condition the level of welfare of the employed population. The study follows a quantitative methodology based on Argentina's Permanent Household Survey. Regression models show a persistent effect over time of social class and job quality on the probability of experiencing poverty and an interaction between both variables, suggesting that job insecurity is a transversal phenomenon across occupational classes.
A NSFD method for the singularly perturbed Burgers-Huxley equation
Authors: Derzie Eshetu B. , Munyakazi Justin B. , Dinka Tekle G.
Published: February 2023

This article focuses on a numerical solution of the singularly perturbed Burgers-Huxley equation. The simultaneous presence of a singular perturbation parameter and the nonlinearity raise the challenge of finding a reliable and efficient numerical solution for this equation via the classical numerical methods. To overcome this challenge, a nonstandard finite difference (NSFD) scheme is developed in the following manner. The time variable is discretized using the backward Euler method. This gives rise to a system of nonlinear ordinary differential equations which are then dealt with using the concept of nonlocal approximation. Through a rigorous error analysis, the proposed scheme has been shown to be parameter-uniform convergent. Simulations conducted on two numerical examples confirm the theoretical result. A comparison with other methods in terms of accuracy and computational cost reveals the superiority of the proposed scheme.
Investigating the suitability of in vitro cell lines as models for the major subtypes of epithelial ovarian cancer
Authors: McCabe Aideen , Zaheed Oza , McDade Simon Samuel , Dean Kellie
Published: February 2023

Epithelial ovarian cancer (EOC) is the most fatal gynaecological malignancy, accounting for over 200,000 deaths worldwide per year. EOC is a highly heterogeneous disease, classified into five major histological subtypes–high-grade serous (HGSOC), clear cell (CCOC), endometrioid (ENOC), mucinous (MOC) and low-grade serous (LGSOC) ovarian carcinomas. Classification of EOCs is clinically beneficial, as the various subtypes respond differently to chemotherapy and have distinct prognoses. Cell lines are often used as in vitro models for cancer, allowing researchers to explore pathophysiology in a relatively cheap and easy to manipulate system. However, most studies that make use of EOC cell lines fail to recognize the importance of subtype. Furthermore, the similarity of cell lines to their cognate primary tumors is often ignored. Identification of cell lines with high molecular similarity to primary tumors is needed in order to better guide pre-clinical EOC research and to improve development of targeted therapeutics and diagnostics for each distinctive subtype. This study aims to generate a reference dataset of cell lines representative of the major EOC subtypes. We found that non-negative matrix factorization (NMF) optimally clustered fifty-six cell lines into five groups, putatively corresponding to each of the five EOC subtypes. These clusters validated previous histological groupings, while also classifying other previously unannotated cell lines. We analysed the mutational and copy number landscapes of these lines to investigate whether they harboured the characteristic genomic alterations of each subtype. Finally we compared the gene expression profiles of cell lines with 93 primary tumor samples stratified by subtype, to identify lines with the highest molecular similarity to HGSOC, CCOC, ENOC, and MOC. In summary, we examined the molecular features of both EOC cell lines and primary tumors of multiple subtypes. We recommend a reference set of cell lines most suited to represent four different subtypes of EOC for both in silico and in vitro studies. We also identify lines displaying poor overall molecular similarity to EOC tumors, which we argue should be avoided in pre-clinical studies. Ultimately, our work emphasizes the importance of choosing suitable cell line models to maximise clinical relevance of experiments.
A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors
Authors: Ma Yufeng , Zhang Fengsen , Zhong Yijing , Huang Yongchun , Yixizhuoma  , Jia Qiangqiang , Zhang Shoude
Published: February 2023

Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP. Inhibiting the activity of PDE5A has proven to be an effective strategy for treating pulmonary arterial hypertension and erectile dysfunction. Current enzymatic activity assay methods for PDE5A mainly use fluorescent or isotope-labeled substrates, which are expensive and inconvenient. Here, we developed an LC/MS-based enzymatic activity assay for PDE5A without labeling, which detects the enzymatic activity of PDE5A by quantifying the substrate cGMP and product GMP at a concentration of 100 nM. The accuracy of this method was verified by a fluorescently labeled substrate. Moreover, a new inhibitor of PDE5A was identified by this method and virtual screening. It inhibited PDE5A with an IC50 value of 870 nM. Overall, the proposed strategy provides a new method for screening PDE5A inhibitors.
The effects of social density, spatial density, noise, and office views on perceived personal space in the virtual workplace
Authors: Jicol Crescent , Taulo Gerald , Goldie Cora , Lloyd-Esenkaya Tayfun , Hynes Ruth , Paradise Caroline , Proulx Michael J. , de Sousa Alexandra A.
Published: February 2023

Here we sought to understand how perceived personal space is influenced by a number of variables that could influence Indoor Environmental Quality (IEQ); specifically, we tested how different levels of social density, spatial density, noise presence, and type of view impact the appreciation of personal space in a shared office environment. We employed virtual reality (VR) to simulate shared and single occupancy offices and devised a novel measure of personal space estimation. We also used a traditional personal space satisfaction score. Participants experienced greater perceived personal space when (1) in a sparsely populated rather than a dense office, (2) in a private office rather than an open plan office, and (3) having any view outside of the office. We did not find an effect of the presence of noise or increased social density (with spatial density held constant) on the perception of personal space.
Model-based shared control approach for a power wheelchair driving assistance system using a force feedback joystick
Authors: Nguyen Viet Thuan , Sentouh Chouki , Pudlo Philippe , Popieul Jean-Christophe
Published: February 2023

This paper presents a haptic-based assistance system (AS) for power wheelchair users designed using the model-based shared control approach. The idea is to combine robust control with a high-level driving supervisor in order to successfully share control authority between the wheelchair user and the assistance system. This shared control strategy is composed of two parts, namely an operational part and a tactical part. Through the haptic joystick interface, this assistance system aims to reduce user’s effort when manipulating the joystick, guide the user to avoid any potential collisions, and maintain the active participation of the user in driving the wheelchair. In the operational part, an optimal Takagi-Sugeno fuzzy control approach is proposed to deal with the time-varying user’s intention represented by his desired longitudinal and angular position errors and velocities and hand torques. The control design is formulated as an LMI optimization problem which can be easily solved with numerical solvers. Two unknown input observers for Takagi-Sugeno fuzzy model have been designed to estimate the user’s intention in order to generate an assistance torque via a haptic force feedback joystick. The control supervisor in the tactical part, aims to provide a decision-making signal which allows for the conflict management based on the user hand torque estimation. A specific algorithm has been developed to solve the conflict between the user’s desired actions and the suggestions from the assistance system to ensure the user remains the final decision-maker. Experimental results show the effectiveness and the validity of the proposed assistance system.
A machine learning approach for predicting descending thoracic aortic diameter
Authors: Yu Ronghuang , Jin Min , Wang Yaohui , Cai Xiujuan , Zhang Keyin , Shi Jian , Zhou Zeyi , Fan Fudong , Pan Jun , Zhou Qing , Tang Xinlong , Wang Dongjin
Published: February 2023

Background

To establish models for predicting descending thoracic aortic diameters and provide evidence for selecting the size of the stent graft for TBAD patients.

Methods

A total of 200 candidates without severe deformation of aorta were included. CTA information was collected and 3D reconstructed. In the reconstructed CTA, a total of 12 cross-sections of peripheral vessels were made perpendicular to the axis of flow of the aorta. Parameters of the cross sections and basic clinical characteristics were used for prediction. The data was randomly split into the training set and the test set in an 8:2 ratio. To fully describe diameters of descending thoracic aorta, three predicted points were set based quadrisection, and a total of 12 models at three predicted points were established using four algorithms included linear regression (LR), support vector machine (SVM), Extra-Tree regression (ETR) and random forest regression (RFR). The performance of models was evaluated by mean square error (MSE) of the prediction value, and the ranking of feature importance was given by Shapley value. After modeling, prognosis of five TEVAR cases and stent oversizing were compared.

Results

We identified a series of parameters which affect the diameter of descending thoracic aorta, including age, hypertension, the area of proximal edge of superior mesenteric artery, etc. Among four predictive models, all the MSEs of SVM models at three different predicted position were less than 2 mm2, with approximately 90% predicted diameters error less than 2 mm in the test sets. In patients with dSINE, stent oversizing was about 3 mm, while only 1 mm in patients without complications.

Conclusion

The predictive models established by machine learning revealed the relationship between basic characteristics and diameters of different segment of descending aorta, which help to provide evidence for selecting the matching distal size of the stent for TBAD patients, thereby reducing the incidence of TEVAR complications.
CARD9 deficiency improves the recovery of limb ischemia in mice with ambient fine particulate matter exposure
Authors: Zhu Qiang , Liu Xuanyou , Wu Hao , Yang Chunlin , Wang Meifang , Chen Feng , Cui Yuqi , Hao Hong , Hill Michael A. , Liu Zhenguo
Published: February 2023

Background

Exposure to fine particulate matter (PM) is a significant risk for cardiovascular diseases largely due to increased reactive oxygen species (ROS) production and inflammation. Caspase recruitment domain (CARD)9 is critically involved in innate immunity and inflammation. The present study was designed to test the hypothesis that CARD9 signaling is critically involved in PM exposure-induced oxidative stress and impaired recovery of limb ischemia.

Methods and results

Critical limb ischemia (CLI) was created in male wildtype C57BL/6 and age matched CARD9 deficient mice with or without PM (average diameter 2.8 μm) exposure. Mice received intranasal PM exposure for 1 month prior to creation of CLI and continued for the duration of the experiment. Blood flow and mechanical function were evaluated in vivo at baseline and days 3, 7, 14, and 21 post CLI. PM exposure significantly increased ROS production, macrophage infiltration, and CARD9 protein expression in ischemic limbs of C57BL/6 mice in association with decreased recovery of blood flow and mechanical function. CARD9 deficiency effectively prevented PM exposure-induced ROS production and macrophage infiltration and preserved the recovery of ischemic limb with increased capillary density. CARD9 deficiency also significantly attenuated PM exposure-induced increase of circulating CD11b+/F4/80+ macrophages.

Conclusion

The data indicate that CARD9 signaling plays an important role in PM exposure-induced ROS production and impaired limb recovery following ischemia in mice.
Estimating the causal effects of genetically predicted plasma proteome on heart failure
Authors: Yang Jian , Yan Bin , Zhang Haoxuan , Lu Qun , Yang Lihong , Liu Ping , Bai Ling
Published: February 2023

Background

Heart Failure (HF) is the end-stage cardiovascular syndrome with poor prognosis. Proteomics holds great promise in the discovery of novel biomarkers and therapeutic targets for HF. The aim of this study is to investigate the causal effects of genetically predicted plasma proteome on HF using the Mendelian randomization (MR) approach.

Methods

Summary-level data for the plasma proteome (3,301 healthy individuals) and HF (47,309 cases; 930,014 controls) were extracted from genome-wide association studies (GWASs) of European descent. MR associations were obtained using the inverse variance-weighted (IVW) method, sensitivity analyses, and multivariable MR analyses.

Results

Using single-nucleotide polymorphisms as instrumental variables, 1-SD increase in MET level was associated with an approximately 10% decreased risk of HF (odds ratio [OR]: 0.92; 95% confidence interval [CI]: 0.89 to 0.95;p = 1.42 × 10−6), whereas increases in the levels of CD209 (OR: 1.04; 95% CI: 1.02–1.06;p = 6.67 × 10−6) and USP25 (OR: 1.06; 95% CI: 1.03–1.08;p = 7.83 × 10−6) were associated with an increased risk of HF. The causal associations were robust in sensitivity analyses, and no evidence of pleiotropy was observed.

Conclusion

The study findings suggest that the hepatocyte growth factor/c-MET signaling pathway, dendritic cells-mediated immune processes, and ubiquitin-proteasome system pathway are involved in the pathogenesis of HF. Moreover, the identified proteins have potential to uncover novel therapies for cardiovascular diseases.
Privacy by design in systems for assisted living, personalised care, and wellbeing: A stakeholder analysis
Authors: Carboni Andrea , Russo Dario , Moroni Davide , Barsocchi Paolo
Published: February 2023

Privacy by design within a system for assisted living, personalised care, and wellbeing is crucial to protect users from misuse of the data collected about their health. Especially if the information is collected through audio–video devices, the question is even more delicate due to the nature of these data. In addition to guaranteeing a high level of privacy, it is necessary to reassure end users about the correct use of these streams. The evolution of data analysis techniques began to take on an important role and increasingly defined characteristics in recent years. The purpose of this paper is twofold: on the one hand, it presents a state of the art about privacy in European Active Healthy Ageing/Active Healthy Ageing projects, with a focus on those related to audio and video processing. On the other hand, it proposes a methodology, developed in the context of the European project PlatfromUptake.eu, to identify clusters of stakeholders and application dimensions (technical, contextual, and business), define their characteristics, and show how privacy constraints affect them. From this study, we then generated a Strengths, Weaknesses, Opportunities, and Threats analysis in which we aim to identify the critical features connected to the selection and involvement of relevant stakeholders for the success of a project. Applying this type of methodology to the initial stages of a project allows understanding of which privacy issues could be related to the various stakeholder groups and which problems can then affect the correct development of the project. The idea is, therefore, to suggest a privacy-by-design approach according to the categories of stakeholders and project dimensions. The analysis will cover technical aspects, legislative and policies-related aspects also regarding the point of view of the municipalities, and aspects related to the acceptance and, therefore, to the perception of the safety of these technologies by the final end users.
Determination of initial velocity of gas diffusion under temperature control
Authors: Shang Xianguang , Wei Jianping , Wen Zhihui , Shang Linwei , Yuan Junling
Published: February 2023

Introduction: The initial velocity of gas diffusion (ΔP) of coal is an important index to characterize the outburst risk of coal, and temperature is an important factor affecting the determination of initial velocity of gas diffusion. However, how to control the temperature during ΔP determination remains a significant challenge. Methods: In this paper, an experimental system for ΔP testing under temperature-controlled conditions was constructed, and the effect of temperature on the ΔP determination results was further explored by accurately controlling the temperature of the testing system. Results: The results show that the temperature change will affect the determination result of ΔP in the range of 13°C–40°C, and the determination results do not show obvious regularity. Discussion: The main reasons for the analysis are as follows: during the determination of ΔP, although the higher the temperature is, the faster the speed of gas diffusion and the greater the amount of gas diffusion and the pressure produced in the first 60 s, but the smaller the amount of gas adsorption before release. There is a situation of mutual offset between the two, resulting in the fluctuation of ΔP determination results. It is concluded that the temperature change will affect the determination of the initial velocity of gas diffusion, and when ΔP is measured, the temperature of the experimental system should be consistent with the actual temperature of the sampled coal body as far as possible, so as to increase the reliability of the measured results for the prediction of coal and gas outburst. This paper provides an experimental basis for clarifying the industry standard of temperature related to ΔP.
Harmonic source localization method for the port distribution system based on the stagewise regularized orthogonal matching pursuit algorithm
Authors: Yang Ruixiang , Yu Moduo , Tai Nengling , Duan Ruochen , Lu Chao
Published: February 2023

The application of power electronic technology which is widely used in large mechanical equipment of ports causes inevitable harmonic pollution issues. Due to the small capacity of the port power system, harmonic interference will bring huge security risks to its normal operation. Therefore, it is necessary to carry out the effective localization of the harmonic sources in the grid. In this paper, a harmonic source localization method based on the stagewise regularized orthogonal matching pursuit (SROMP) is proposed by improving the orthogonal matching pursuit (OMP) in a compressed sensing theory. It can achieve accurate localization of harmonic sources only through measurement information analysis, which is significantly superior to traditional methods. First, according to the grid topology and line parameters, a system equation is constructed that takes the node harmonic voltage as the measurement variable and the harmonic current injected to the node as the state variable. Next, the equation is solved to obtain the harmonic current value injected to each node. The result can reflect the harmonic injection situation of each node, so as to determine the position of each harmonic source. In order to test the localization effect of the algorithm under different measurement configurations, the SROMP method is compared with other algorithms in considerable simulation experiments on the improved IEEE-33 model, which verifies the stability and accuracy of the proposed algorithm.
To what extent does renewable energy deployment reduce pollution indicators? the moderating role of research and development expenditure: Evidence from the top three ranked countries
Authors: Gharbi Inés , Kammoun Aïda , Kefi Mohamed Karim
Published: February 2023

Climate change, pollution, drought, and rising seas impede the achievement of the seventh sustainable development goal SDG#7 “affordable and clean energies”. To counter these threats, the use of Renewable Energy (RE) as an alternative to conventional energy plays an important role in sustainable development. In this context, the purpose of our paper is to investigate the effect of Renewable Energy deployment on environmental protection in China, The United States of America (USA), and Germany: the top three ranked countries in terms of REs production, according to RENEWABLE 2021 GLOBAL STATUSREPORT. To achieve this objective, the paper adopts a Panel fully modified OLS (FMOLS) method. Results declare that renewable energy significantly reduce pollution indicators; furthermore, we find that Research and development fully moderate this relationship. The findings of this study emphasize the importance of increasing spending on Research and development activities in the RE sector. In addition, the countries studied and countries around the world should pay greater attention to investment in research and development to support the long-term plan for advancing sustainable energy sources for feasible energy and economic development.
Sustainability assessment of rural toilet technology based on the unascertained measure theory
Authors: Wu Simei , Chai Qing , Liu Xiaojun , He Bao-Jie
Published: February 2023

Upgrading toilets in rural areas is an effective way to protect public health and reduce environmental pollution. Although there are studies on rural toilets, the sustainable performance of rural toilets in developing areas is considerably less understood. The study aims to build a sustainability assessment model of rural toilet technology to support the local government in upgrading rural toilets. The unascertained measure theory is integrated into the model to quantify the sustainability performance of rural toilet technology in three dimensions: economy, service and management, and environment. A case study of Honghai Village, Inner Mongolia, China, is conducted to verify the reliability of the sustainability assessment model. The results indicate that the sustainability performance of the three-compartment septic tank toilet technology is good in Honghai Village. The results are consistent with the situation of the three-compartment septic tank toilets in the village, which verifies the model’s validity. This study can help local government significantly upgrade rural toilets and improve the living standards of rural residents.
Collectivism culture and green transition: An empirical investigation for the rice theory
Authors: Qu Danxue
Published: February 2023

With growing concerns worldwide on global warming, emissions reduction has become a major challenge for many countries. China, as the largest carbon emitter, has played a key role in achieving global green transition. Using panel data from 2004–2017 on 31 Chinese provinces, this study examines the relationship between the collectivism culture and green transition. My results reveal that places with a stronger collectivism culture tend to make more green investments, and the results remain valid after a battery of robustness tests. In addition, the heterogeneity analysis indicates that the positive effects of collectivism culture on green investments are more pronounced if the province governor is advanced in age, well educated, and holds a long tenure. Additionally, such effects are more conspicuous in those provinces with more serious pollution, greater levels of collectivism, and more developed markets. This study fills a theoretical gap in the field of research on green investments from a cultural perspective. Therefore, this study has important implications for promoting green development and achieve carbon peaking and neutrality.
Metals and metal isotopes incorporation in insect wings: Implications for geolocation and pollution exposure
Authors: Reich Megan S. , Kindra Mira , Dargent Felipe , Hu Lihai , Flockhart D. T. Tyler , Norris D. Ryan , Kharouba Heather , Talavera Gerard , Bataille Clément P.
Published: February 2023

Anthropogenic activities are exposing insects to elevated levels of toxic metals and are altering the bioavailability of essential metals. Metals and metal isotopes have also become promising tools for the geolocation of migratory insects. Understanding the pathways of metal incorporation in insect tissues is thus important for assessing the role of metals in insect physiology and ecology and for the development of metals and metal isotopes as geolocation tools. We conducted a diet-switching experiment on monarch butterflies [Danaus plexippus (L.)] with controlled larval and adult diets to evaluate the sources of 23 metals and metalloids, strontium isotopes, and lead isotopes to insect wing tissues over a period of 8 weeks. Concentrations of Ca, Co, Mo, and Sb differed between the sexes or with body mass. Ni and Zn bioaccumulated in the insect wing tissues over time, likely from the adult diet, while increases in Al, Cr, Cd, Cu, Fe, and Pb were, at least partially, from external sources (i.e., dust aerosols). Bioaccumulation of Pb in the monarch wings was confirmed by Pb isotopes to mainly be sourced from external anthropogenic sources, revealing the potential of Pb isotopes to become an indicator and tracer of metal pollution exposure along migratory paths. Concentrations of Ba, Cs, Mg, Na, Rb, Sr, Ti, Tl, and U appeared to be unaffected by intrinsic factors or additions of metals from adult dietary or external sources, and their potential for geolocation should be further explored. Strontium isotope ratios remained indicative of the larval diet, at least in males, supporting its potential as a geolocation tool. However, the difference in strontium isotope ratios between sexes, as well as the possibility of external contamination by wetting, requires further investigation. Our results demonstrate the complexity of metal incorporation processes in insects and the value of studying metals to develop new tools to quantify pollution exposure, metal toxicity, micronutrient uptake, and insect mobility.
CRISPR/Cas genome editing system and its application in potato
Authors: Hou Xin , Guo Xiaomeng , Zhang Yan , Zhang Qiang
Published: February 2023

Potato is the largest non-cereal food crop worldwide and a vital substitute for cereal crops, considering its high yield and great nutritive value. It plays an important role in food security. The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated) system has the advantages of easy operation, high efficiency, and low cost, which shows a potential in potato breeding. In this paper, the action mechanism and derivative types of the CRISPR/Cas system and the application of the CRISPR/Cas system in improving the quality and resistance of potatoes, as well as overcoming the self-incompatibility of potatoes, are reviewed in detail. At the same time, the application of the CRISPR/Cas system in the future development of the potato industry was analyzed and prospected.
Neural functions in cancer: Data analyses and database construction
Authors: Tan Renbo , Wang Feilong , Zhou Yi , Huang Zhenyu , An Zheng , Xu Ying
Published: February 2023

Recent studies have revealed that neural functions are involved in possibly every aspect of a cancer development, serving as bridges connecting microenvironmental stressors, activities of intracellular subsystems, and cell survival. Elucidation of the functional roles played by the neural system could provide the missing links in developing a systems-level understanding of cancer biology. However, the existing information is highly fragmented and scattered across the literature and internet databases, making it difficult for cancer researchers to use. We have conducted computational analyses of transcriptomic data of cancer tissues in TCGA and tissues of healthy organs in GTEx, aiming to demonstrate how the functional roles by the neural genes could be derived and what non-neural functions they are associated with, across different stages of 26 cancer types. Several novel discoveries are made, including i) the expressions of certain neural genes can predict the prognosis of a cancer patient; ii) cancer metastasis tends to involve specific neural functions; iii) cancers of low survival rates involve more neural interactions than those with high survival rates; iv) more malignant cancers involve more complex neural functions; and v) neural functions are probably induced to alleviate stresses and help the associated cancer cells to survive. A database, called NGC, is developed for organizing such derived neural functions and associations, along with gene expressions and functional annotations collected from public databases, aiming to provide an integrated and publicly available information resource to enable cancer researchers to take full advantage of the relevant information in their research, facilitated by tools provided by NGC.
Identification of key candidate genes and pathways in rheumatoid arthritis and osteoarthritis by integrated bioinformatical analysis
Authors: Huang Huijing , Dong Xinyi , Mao Kaimin , Pan Wanwan , Nie Bin’en , Jiang Lindi
Published: February 2023

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the most common joint disorders. Although they have shown analogous clinical manifestations, the pathogenesis of RA and OA are different. In this study, we used the online Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE153015 to identify gene signatures between RA and OA joints. The relevant data on 8 subjects obtained from large joints of RA patients (RA-LJ), 8 subjects obtained from small joints of RA patients (RA-SJ), and 4 subjects with OA were investigated. Differentially expressed genes (DEGs) were screened. Functional enrichment analysis of DEGs including the Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were identified, which were mainly associated with T cell activation or chemokine activity. Besides, protein-protein interaction (PPI) network analysis was performed, and key modules were identified. Hub genes of RA-LJ and OA groups were screened, they were CD8A, GZMB, CCL5, CD2, and CXCL9, whereas CD8A, CD2, IL7R, CD27, and GZMB were hub genes of RA-SJ and OA group. The novel DEGs and functional pathways between RA and OA identified in this study may provide new insight into the underlying molecular mechanisms and therapeutic strategies of RA and OA.