bluuebunny/crossref_metadata_2025 huggingface dataset:
Material Characterization of (C+N) Austenitic Stainless Steel Manufactured by Laser Powder Bed Fusion
Authors: Blankenhagen Jakob , Diller Johannes , Siebert Dorina , Hegele Patrick , Radlbeck Christina , Mensinger Martin
Published: January 2025

The potential of an optimization process with respect to reduced mass can be used to the full extent by utilizing a high-strength material as it is, among others, strength-dependent. For the additive manufacturing process, Powder Bed Fusion of Metals using a Laser Beam (PBF-LB/M), 316L is commonly used. PBF-LB/M/316L has its benefits, like good material properties, such as availability, corrosion resistance, strength, and ductility. Nevertheless, a higher-strength material is required to fully take advantage of the optimization process and achieve a greater reduction in the mass of manufactured parts. The high-strength austenitic stainless steel investigated in this study is Printdur® HSA. Its main alloying elements are manganese, chromium, molybdenum, carbon, and nitrogen. The steel obtains its high strength properties from the alloyed carbon and nitrogen via solid solution hardening and improving the austenite stability. Therefore, it is defined as (C+N) steel. The datasheet of the powder manufacturer describes a yield strength (Rp0.2; 0.2% offset proof stress) of 915 MPa, an ultimate tensile strength of 1120 MPa, and an elongation at fracture of 30%. These are clear benefits in comparison to PBF-LB/M/316L. Since there are no further investigations made on Printdur® HSA, a thorough investigation of material behavior, fatigue life, and microstructure is needed.
Phase Field Simulation of Al-Fe-Mn-Si Quaternary Eutectic Solidification
Authors: NouraniNiaki Kimiya , Uddagiri Murali , Isidorio Daysianne , Shchyglo Oleg , Steinbach Ingo
Published: January 2025

This study investigates the eutectic equilibrium phases in a multicomponent system through 3-D multi-phase-field simulations. Emphasizing the directional solidification process, the work examines the growth dynamics of intermetallic phase Al13Fe4, a lamellar structure (FCC-A1), and a quaternary phase beta-AlMnSi from the liquid that is solidified at a specific temperature. The eutectic transformation, described by the four phase reaction L→Al13Fe4+FCC-A1+beta-AlMnSi, is analyzed to develop a microstructure selection map. This map correlates stable growth modes with initial system composition and lamellar spacing. The results provide detailed insights into the segregation behaviour of alloying elements and their influence on transformation kinetics, enhancing the understanding of eutectic microstructure evolution in complex alloy systems.
Research Advances in Additively Manufactured High-Entropy Alloys: Microstructure, Mechanical Properties, and Corrosion Resistance
Authors: Han Feng , Li Chunyang , Huang Jiqiang , Wang Jiacai , Xue Long , Wang Caimei , Zhang Yu
Published: January 2025

High-entropy alloys have garnered significant attention due to their unique composition and exceptional properties. Additive manufacturing technology, with its distinctive processing methods, offers new options for the fabrication of high-entropy alloys. However, due to the diversity of high-entropy alloys and additive manufacturing technologies, it is imperative to provide a comprehensive overview of the high-entropy alloys produced using various additive manufacturing methods. This paper presents a summary of the microstructure, mechanical properties, and corrosion resistance of high-entropy alloys fabricated using different additive manufacturing techniques. This paper initially reviews the impact of various additive manufacturing process parameters and the influence of different elements on the microstructure of additively manufactured high-entropy alloys. Subsequently, it discusses the effects of different additive manufacturing techniques on mechanical properties and summarizes four strengthening mechanisms in additively manufactured high-entropy alloys. Additionally, the corrosion resistance of various additively manufactured high-entropy alloys is summarized. Finally, based on the review of additively manufactured high entropy alloys presented in this paper, the current challenges and future research directions are proposed.
Nano-Titania Photocatalysis and Metal Doping to Deter Fungal Growth on Outdoor and Indoor Paint Surfaces Using UV and Fluorescent Light
Authors: Whitehead Kathryn A. , Brown Mark , Caballero Lucia , Lynch Stephen , Edge Michele , Hill Claire , Verran Joanna , Allen Norman S.
Published: January 2025

This work determined the resistance of paint formulations containing TiO2 particles to fungal growth. Siloxane, acrylic and silicone paints were placed outdoors, and the fungal species growing thereon were recorded after 3, 6 and 9 months. In addition, three paint types containing TiO2 with/without biocide were inoculated with fungal spores and irradiated using UV. Acrylic paints were also doped with different metals and were inoculated and incubated under fluorescent light. Following outdoor incubation, the silicone paint was the least colonised by different fungal species. The species most recovered from the surfaces were Aspergillus spp. and Penicillium spp. Following UV irradiation on different paints containing biocide and/or a photocatalyst, no fungal growth was demonstrated on some of the paint combinations. When the paint samples were doped with different metals and incubated using light, the sample most efficient at preventing fungal growth contained lanthanum (0.004%). The paint samples containing praseodymium (light:1.72) facilitated the densest fungal colonies. Most of the surfaces demonstrated heterogeneous coverage by the fungi. The most clustered fungal colonisation was on surfaces incubated in the light. This work demonstrated that fungal colonisation on paints changed over time and that the antimicrobial efficacy of TiO2 was affected by the chemical composition, biocide and doping of the paint.
Sex Differences and Pathogen Patterns in Surgically Treated Aortic Valve Endocarditis over 15 Years
Authors: Mikus Elisa , Fiorentino Mariafrancesca , Sangiorgi Diego , Costantino Antonino , Calvi Simone , Tenti Elena , Tremoli Elena , Tripodi Alberto , Savini Carlo
Published: January 2025

Background: Infective endocarditis (IE) is a serious public health concern due to its high morbidity and lethality. This study investigates epidemiological trends in aortic valve endocarditis, focusing on sex-related differences in microbial etiology and surgical outcomes over a 15-year period. Methods: From January 2010 to January 2024, 608 patients underwent cardiac surgery for IE at our center. Of these, 274 patients received isolated aortic valve replacement. This retrospective, single-center study analyzes these cases. Results: Despite a decline in overall aortic valve replacement surgeries, a significant increase in surgeries due to aortic valve endocarditis was observed (p < 0.001). Both sexes showed a rising incidence of aortic valve endocarditis, with females undergoing surgery at an older age, particularly in native valve cases (p = 0.008). In prosthetic valve cases, this age difference was less pronounced (p = 0.050). While sex did not influence microbial etiology in native valve endocarditis, females with prosthetic valves were more frequently infected by Streptococcus (p = 0.033). Staphylococcus aureus infections increased in native valves (p = 0.016). Conclusions: Over 15 years, surgical aortic valve endocarditis has risen in both sexes. Males are more often affected by native valve cases, while females develop it later. Neither gender nor microbial etiology independently predicts death.
Characteristics and Mechanism of Ammonia Nitrogen Removal by Heterotrophic Nitrification Bacterium Klebsiella pneumoniae LCU1 and Its Application in Wastewater Treatment
Authors: Xu Meng , Chen Lifei , Xin Yizhen , Wang Xiangyu , Wang Zhuoya , Meng Xueqiang , Zhang Wenyu , Sun Haoyang , Li Yifan , Zhang Wenzhe , Wan Peng , Geng Bingshuai , Li Lusheng
Published: January 2025

In this study, a novel strain exhibiting heterotrophic nitrification was screened; subsequently, the strain was identified as Klebsiella pneumoniae LCU1 using 16S rRNA gene sequencing. The aim of the study was to investigate the effects of external factors on the NH4+-N removal efficiency of strain LCU1 in order to elucidate the optimal conditions for NH4+-N removal by the strain and improve the removal efficiency. The findings indicated that the NH4+-N removal efficiency of the strain exceeded 80% under optimal conditions (sodium succinate carbon source, C/N ratio of 10, initial pH of 8.0, temperature of 30 °C, and speed of 180 rpm). The genome analysis of strain LCU1 showed that key genes involved in nitrogen metabolism, including narGHI, nirB, nxrAB, and nasAB, were successfully annotated; hao and amo were absent, but the nitrogen properties analysis determined that the strain had a heterotrophic nitrification ability. After 120 h, the NH4+-N removal efficiency of strain LCU1 was 34.5% at a high NH4+-N concentration of 2000 mg/L. More importantly, the NH4+-N removal efficiency of this strain was above 34.13% at higher Cu2+, Mn2+, and Zn2+ ion concentrations. Furthermore, strain LCU1 had the highest NH4+-N removal efficiency of 34.51% for unsterilised (LCU1-OC) aquaculture wastewater. This suggests that with intensive colonisation treatment, the strain has promising application potential in real wastewater treatment.
Analysis of Reported Cases of Giardia lamblia and Cryptosporidium spp. Infection in Children from Aragón (Northeast Spain) During the Period (2012–2021)
Authors: Lafarga-Molina Laura , Rubio Encarnación , Seral Cristina , Rezusta Antonio , Lizán Pilar Egido , Malo Aznar Carmen , Casanovas-Marsal Josep-Oriol , Fernández Rodrigo María Teresa , Goñi Pilar
Published: January 2025

Giardiasis and cryptosporidiosis, caused by Giardia lamblia and Cryptosporidium spp., are parasitic infections transmitted through faecal–oral routes or contaminated water. Although less common in Spain compared to developing countries, they pose a public health concern, particularly for vulnerable groups like children and immunocompromised individuals. This study aims to analyse the cases reported to the Microbiological Information System (MIS) in children between 2012 and 2021, as well as their distribution across sociodemographic variables. Proportions and infectivity rates were determined for epidemiological and sociodemographic data, and the incidence rate for giardiasis and cryptosporidiosis was calculated annually and by health sector. The variables analysed included sex, age, health sector and weather. For both diseases, there was a significant decrease in the number of cases in 2020, suggesting the importance of person-to-person transmission. Children were infected by Giardia in significantly higher proportion (p < 0.001), being the majority in age groups 5–14 years, while the proportion of boys and girls infected by Cryptosporidium was almost identical (1.4% vs. 1.3%), in children aged 2–4 years. Periodically there was a significant increase in cases of cryptosporidiosis, apparently related to the presence of torrential rains. Transmission is related to increased temperature and rainfall. Person-to-person transmission in the paediatric population needs further investigation. This study provides the foundation for future research on the evolution of cases of giardiasis and cryptosporidiosis in Spanish children. The data emphasise the need for informational campaigns on hygienic measures and efforts by public health authorities to maintain water resources in optimal condition to prevent parasite spread.
Advancing Iron Ore Grade Estimation: A Comparative Study of Machine Learning and Ordinary Kriging
Authors: Maniteja Mujigela , Samanta Gopinath , Gebretsadik Angesom , Tsae Ntshiri Batlile , Rai Sheo Shankar , Fissha Yewuhalashet , Okada Natsuo , Kawamura Youhei
Published: January 2025

Mineral grade estimation is a vital phase in mine planning and design, as well as in the mining project’s economic assessment. In mining, commonly accepted methods of ore grade estimation include geometrical approaches and geostatistical techniques such as kriging, which effectively capture the spatial grade variation within a deposit. The application of machine-learning (ML) techniques has been explored in the estimation of mineral resources, where complex correlations need to be captured. In this paper, the authors developed four machine-learning regression models, i.e., support vector regression (SVR), random forest regression (RFR), k-nearest neighbour (KNN) regression, and extreme gradient boost (XGBoost) regression, using a geological database to predict the grade in an Indian iron ore deposit. When compared with ordinary kriging (R2 = 0.74; RMSE = 2.09), the RFR (R2 = 0.74; RMSE = 2.06), XGBoost (R2 = 0.73; RMSE = 2.12), and KNN (R2 = 0.73; RMSE = 2.11) regression models produced similar results. The block model predictions generated using the RFR, XGBoost, and KNN models show comparable accuracy and spatial trends to those of ordinary kriging, whereas SVR was identified as less effective. When integrated with geological methods, these models demonstrate significant potential for enhancing and optimizing mine planning and design processes in similar iron ore deposits.
Synthesis and Antimycobacterial Assays of Some New Ethambutol Analogs
Authors: Abdelaziz Rana , Dube Mthandazo , Mann Lea , Richter Adrian , Robaa Dina , Reiling Norbert , Abdel-Halim Mohammad , Imming Peter
Published: January 2025

Ethambutol (EMB) is a first-line anti-tuberculosis drug that is also considered in treatment regimens for infections caused by non-tuberculous mycobacteria (NTM). EMB targets the arabinosyl transferases EmbCAB, which are important for the synthesis of cell wall constituents. To further explore and narrow down the structural variability of EMB, we synthesized three series of new EMB analogs. We tested their activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium abscessus and Mycobacterium intracellulare. Only analogs that very closely resembled EMB showed comparable antimycobacterial activity.
Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects
Authors: van de Wetering Ross , Vu Loan Y. , Kornberger Lindsay D. , Luo Dan , Scouller Brittany , Hong Sheein , Paton Kelly , Prisinzano Thomas E. , Kivell Bronwyn M.
Published: January 2025

Kappa opioid receptor (KOR) agonists have well-established antinociceptive effects. However, many KOR agonists have negative side effects, which limit their therapeutic potential. Some researchers have suggested that the development of biased agonists that preferentially stimulate KOR G-protein pathways over β-arrestin pathways may yield drugs with fewer adverse side effects. This was investigated in the current study. We describe the synthesis and characterization of three U50,488 analogues, 1, 2, and 3. We evaluated the acute and chronic antinociceptive effects of these compounds in mice using the warm-water tail flick assay and in a paclitaxel-induced neuropathic pain model. Side effects were investigated using open-field, passive wire hang, rotarod, elevated zero maze, conditioned place aversion, and whole-body plethysmography, with some tests being conducted in KOR or β-arrestin2 knock out mice. All compounds were highly potent, full agonists of the KOR, with varying signaling biases in vitro. In the warm-water tail withdrawal assay, these agonists were ~10 times more potent than U50,488, but not more efficacious. All KOR agonists reversed paclitaxel-induced neuropathic pain, without tolerance. Compound 3 showed no significant side effects on any test. Signaling bias did not correlate with the antinociceptive or side effects of any compounds and knockout of β-arrestin2 had no effect on U50,488-induced sedation or motor incoordination. These findings highlight the therapeutic potential of 3, with its lack of side effects typically associated with KOR agonists, and also suggest that G-protein signaling bias is a poor predictor of KOR agonist-induced side effects.
Improved Ferroelectric and Magnetic Properties of Bismuth Ferrite-Based Ceramics by Introduction of Non-Isovalent Ions and Grain Engineering
Authors: Wang Ting , Ye Huojuan , Wang Xiaoling , Cui Yuhan , Mei Haijuan , Song Shenhua , Zhao Zhenting , Wang Meng , Rosaiah Pitcheri , Ma Qing
Published: January 2025

Single-phase multiferroics exhibiting ferroelectricity and ferromagnetism are considered pivotal for advancing next-generation multistate memories, spintronic devices, sensors, and logic devices. In this study, the magnetic and electric characteristics of bismuth ferrite (BiFeO3) ceramics were enhanced through compositional design and grain engineering. BiFeO3 ceramic was co-substituted by neodymium (Nd) and niobium (Nb), two non-isovalent elements, via the spark plasma sintering process using phase-pure powder prepared via sol-gel as the precursor. The symmetry of the sintered Nd–Nb co-doped samples changed from R3c to Pnma, accompanied by a decrease in the loss tangent, grain size, and leakage current density. The reduction in the leakage current density of the co-doped samples was ~three orders of magnitude. Moreover, ferroelectric, dielectric, and magnetic properties were substantially improved. The remanent polarization and magnetization values of the optimized Nd–Nb co-doped BiFeO3 sample were 3.12 μC cm−2 and 0.15 emu g−1, respectively. The multiferroic properties were enhanced based on multiple factors such as structural distortion caused by co-doping, grain size reduction, suppression of defect charges via donor doping, space-modulated spin structure disruption, and an increase in magnetic ions. The synergistic approach of composition design and grain engineering sets a paradigm for the advancement of multiferroic materials.
Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies
Authors: Dileo Eleonora , Saba Francesca , Parasiliti-Caprino Mirko , Rosso Chiara , Bugianesi Elisabetta
Published: January 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a spectrum of liver disease ranging from hepatic fat accumulation to steatohepatitis (metabolic dysfunction-associated steatohepatitis, MASH), fibrosis, cirrhosis, and potentially hepatocellular carcinoma in the absence of excessive alcohol consumption. MASLD is characterized by substantial inter-individual variability in terms of severity and rate of progression, with a prevalence that is generally higher in men than in women. Steroids metabolism is characterized by sexual dimorphism and may have an impact on liver disease progression; indeed, several therapeutic strategies targeting hormone receptors are under phase 2/3 development. Despite the fact that the importance of sexual dimorphism in the setting of MASLD is well recognized, the underlying molecular mechanisms that can potentially drive the disease toward progression are not clear. The aim of this review is to delve into the crosstalk between sexual dimorphism and steroid hormone perturbation under nutritional and pharmacological intervention.
The Dietary Inflammatory Index and Sarcopenia in Older Adults in Four Chinese Provinces: A Cross-Sectional Study
Authors: Pu Rongchang , Man Qingqing , Song Shuang , Jia Shanshan , Liu Zhen , Zhang Xiaona , Zhang Jian , Song Pengkun
Published: January 2025

Background: Sarcopenia associated with aging severely affects the quality of life of the elderly; diets have been shown to elicit an inflammatory response in the body, and diets that promote inflammation may lead to damage to muscles. The Dietary Inflammatory Index (DII) has been developed to quantify the inflammatory potential of individual diets. Therefore, this study aimed to investigate the association between the DII, sarcopenia and its components in elderly Chinese people. Methods: In this study, data were obtained from the China Nutrition Improvement Strategies and Applications for the Elderly Research Programme. An assessment of sarcopenia was carried out according to the Asian Working Group on Sarcopenia’s (AWGS2019) criteria. The DII was calculated using food intake data obtained using the FFQ method, and then the quartile method was used to categorize the subjects into four groups. Multifactor logistic regression was conducted to examine the associations between DII, sarcopenia and its components. Results: This study included 993 subjects over the age of 65, and the prevalence of sarcopenia was 20.2%. The mean DII score of the study population was 0.99 ± 0.1. After adjusting for the confounders age, gender, marital status, and educational level, the risk of sarcopenia was 1.66 times higher in group Q4 than in group Q1 (p-trend < 0.05). However, this relationship is not statistically significant when other more confounding factors are added. Nevertheless, when further analyzing the relationship between DII and sarcopenia components, it was found that after adjusting the model, a higher DII was associated with a risk of muscle strength loss (OR = 1.65, p-trend < 0.05). Conclusions: Higher DII scores increase the risk of muscle strength loss in older adults. By guiding older adults to adopt a more anti-inflammatory diet, muscle health can be improved in terms of increased muscle strength. Further cohort or interventional studies are necessary to validate our findings.
Development of New Equation for Predicting State of Normometabolism from Cohort of Hospitalized Patients with Obesity
Authors: Mazzola Giuseppe , Rondanelli Mariangela , Cattaneo Carlo , Lazzarotti Alessandro , Gasparri Clara , Barrile Gaetan Claude , Moroni Alessia , Mansueto Francesca , Minonne Leonardo , Perna Simone
Published: January 2025

Background/Objectives: Existing resting energy expenditure (REE) predictive equations, including Mifflin-St Jeor and Harris–Benedict, show limited accuracy, particularly in patients with a BMI over 35, often leading to overestimation or underestimation of REE. This study aimed to develop a new predictive equation specifically designed to identify normometabolic status in patients with obesity, enabling more precise qualitative assessments of basal metabolism through indirect calorimetry. Methods: A cohort of 89 hospitalized patients with obesity (BMI > 30) underwent REE measurement and comprehensive anthropometric assessments. Patients were classified as normometabolic if their REE was within ±10% of the Mifflin-St Jeor prediction or if their fat-free mass-specific REE fell between 23 and 30 kcal/kg. Results: The newly developed equation demonstrated high predictive accuracy (R2 = 0.923, root mean square error = 81.872 kcal/day), with a mean bias of −0.054 kcal/day and narrower limits of agreement (−156.834 to 156.725 kcal/day) compared to widely used models. Conclusions: These advancements could enhance follow-up and management of diet therapy in patients with obesity, allowing for a more tailored approach to their metabolic health over time.
Chrebp Deletion and Mild Protein Restriction Additively Decrease Muscle and Bone Mass and Function
Authors: Deguchi Kanako , Ushiroda Chihiro , Hidaka Shihomi , Tsuchida Hiromi , Yamamoto-Wada Risako , Seino Yusuke , Suzuki Atsushi , Yabe Daisuke , Iizuka Katsumi
Published: January 2025

Background/Objectives: Carbohydrate and protein restriction are associated with sarcopenia and osteopenia, but the underlying mechanisms remain unclear. We aimed to determine whether mild protein restriction affects muscle and bone function in wild-type (WT) and homozygous carbohydrate response element binding protein (Chrebp) knockout (KO) mice. Methods: Eighteen-week-old male wild-type and homozygous carbohydrate response element binding protein (Chrebp) knockout (KO) mice were fed a control diet (20% protein) or a low-protein diet (15% protein) for 12 weeks. We estimated the muscle weight and limb grip strength as well as the bone mineral density, bone structure, and bone morphometry. Results: Chrebp deletion and a low-protein diet additively decreased body weight (WT control–KO low-protein: mean difference with 95% CI, 8.7 [6.3, 11.0], p < 0.0001) and epidydimal fat weight (1.0 [0.7, 1.2], p < 0.0001). Chrebp deletion and a low-protein diet additively decreased tibialis anterior muscle weight (0.03 [0.01, 0.05], p = 0.002) and limb grip strength (63.9 [37.4, 90.5], p < 0.0001) due to a decrease in insulin/insulin-like growth factor 1 mRNA and an increase in myostatin mRNA. In contrast, Chrebp deletion increased bone mineral density (BMD) (WT control–KO control: –6.1 [–1.0, –2.3], p = 0.0009), stiffness (–21.4 [–38.8, –4.1], p = 0.011), cancellous bone BV/TV (–6.517 [–10.99, –2.040], p = 0.003), and the number of trabeculae (–1.1 [–1.8, –0.5], p = 0.0008). However, in KO mice, protein restriction additively decreased BMD (KO control–KO low-protein: 8.1 [4.3, 11.9], p < 0.0001), bone stiffness (38.0 [21.3, 54.7], p < 0.0001), cancellous bone BV/TV (7.7 [3.3, 12.2], p = 0.006), and the number of trabeculae (1.2 [0.6, 1.9], p = 0.0004). The effects of mild protein restriction on bone formation parameters (osteoid volume (WT control–WT low-protein: –1.7 [–2.7, –0.7], p = 0.001) and the osteoid surface (–11.2 [–20.8, –1.5], p = 0.02) were observed only in wild-type (WT) mice. The levels of bone resorption markers, such as the number of osteoclasts on the surface, the number of osteoclasts, and surface erosion, did not differ between the groups. Conclusions: Both Chrebp deletion and protein restriction led to a decrease in muscle and bone function; therefore, an adequate intake of carbohydrates and proteins is important for maintaining muscle and bone mass and function. Further studies will be needed to elucidate the mechanisms by which ChREBP deletion and a low-protein diet cause osteosarcopenia.
Diverse Roles of Antibodies in Antibody–Drug Conjugates
Authors: Yamaguchi Aiko , Manning H. Charles
Published: January 2025

The emergence of antibody–drug conjugates (ADCs) has transformed the treatment landscape of a variety of cancers. ADCs typically consist of three main components: monoclonal antibody, chemical linker, and cytotoxic payload. These integrated therapeutic modalities harness the benefits of each component to provide a therapeutic response that cannot be achieved by conventional chemotherapy. Antibodies play roles in determining tumor specificity through target-mediated uptake, prolonging the circulation half-life of cytotoxic payloads, and providing additional mechanisms of action inherent to the original antibody, thus significantly contributing to the overall performance of ADCs. However, ADCs have unique safety concerns, such as drug-induced adverse events related to the target-mediated uptake of the ADC in normal tissues (so-called “on-target, off-tumor toxicity”) and platform toxicity, which are partially derived from limited tumor uptake of antibodies. Identifying suitable target antigens thus impacts the clinical success of ADCs and requires careful consideration, given the multifaceted aspects of this unique treatment modality. This review briefly summarizes the representative roles that antibodies play in determining the efficacy and safety of ADCs. Key considerations for selecting suitable cell surface target antigens for ADC therapy are also highlighted.
The Efficacy of Honey for the Treatment of Perineal Wounds Following Vaginal Birth: A Narrative Review
Authors: Schaap Isa S. , Lardenoije Céline M. J. G. , Riel Senna J. J. M. van , Cremers Niels A. J.
Published: January 2025

Background/Objectives: During vaginal delivery, the perineum can be damaged either by episiotomy or by a spontaneous perineal tear, leading to several complications. The wound healing process should proceed as quickly and properly as possible without an infection. Medical grade honey (MGH) may be a potent treatment option due to its antimicrobial and pro-healing activities. This literature study investigated the role of honey in the treatment of vaginal wounds after delivery. Methods: Studies published before 17 July 2024 in the PubMed, Web of Science, Embase, Scopus, EBSCO host/CINAHL, Cochrane Library, and Google Scholar databases about honey, episiotomy wounds, and perineal tears, as well as those investigating wound healing and/or pain, were assessed. Results: Ten studies were included (six RCTs, of which three were double-blind, one was quasi-experimental with a posttest only, and three were observational studies without a control group), with 723 participants in total. Six of the seven controlled studies showed honey significantly improved various outcome measures, such as improved wound healing, and reduced need for pain medication. The three non-controlled studies also had a positive outcome, improving wound healing and decreasing pain intensity and prickling sensation. However, the overall quality of available evidence is limited. Different types of honey concentrations, origins, and additives were used in the included studies. Using a standardized MGH formulation may help to maintain consistent and potent effects. Therefore, additional research is needed to determine the efficacy of MGH in perineal trauma and to establish guidelines for clinical use. Conclusions: Honey potentially has a great effect on wound healing of perineal trauma; however, more research is necessary to substantiate the findings in the current literature.
Pharmacists’ Perspectives on Nicotine Vaping Products (NVPs) for Smoking Cessation in Australia: A Qualitative Analysis
Authors: Le David , Saba Maya , Bhurawala Habib , Rahman Muhammad Aziz , Shah Smita , Saini Bandana
Published: January 2025

Vaping, particularly the use of nicotine vaping products (NVPs), has emerged as a public health concern. The regulatory environment surrounding NVPs in Australia has rapidly evolved, shifting from a prescription-only model to availability through community pharmacies. Pharmacists play a critical role in addressing vaping-related health concerns. This study explores Australian pharmacists’ perspectives on their professional roles and the support needed to manage vaping-related enquiries. Qualitative semi-structured interviews were conducted with 25 practicing pharmacists using a topic guide developed from the current literature and team expertise. The interviews were transcribed verbatim and analysed thematically using an inductive approach to identify key themes. Key themes included risk perception, professional vaping health-related services, professional practice and other support-related needs. Pharmacists expressed significant uncertainty about the risks and harms associated with vaping. There was apprehension around the regulatory complexity of supplying NVPs, and participants called for greater education and support, particularly around NVP’s place in smoking cessation and potential vaping cessation services. Effective public health messaging and risk communication about vaping are crucial. At the centre of recent legislative changes, pharmacists require training and professional support to address vaping-related scenarios and provide counselling that aligns with individual risk perceptions, ensuring NVP use is clinically appropriate.
Localized Effects in Graphene Oxide Systems: A Pathway to Hyperbolic Metamaterials
Authors: Politano Grazia Giuseppina
Published: January 2025

Graphene oxide (GO) has emerged as a carbon-based nanomaterial providing a different pathway to graphene. One of its most notable features is the ability to partially reduce it, resulting in graphene-like sheets through the elimination of oxygen-including functional groups. In this paper, the effect of localized interactions in an Ag/GO/Au multilayer system was studied to explore its potential for photonic applications. GO was dip-coated onto magnetron-sputtered silver, followed by the deposition of a thin gold film to form an Ag/GO/Au structure. Micro-Raman Spectroscopy, SEM and Variable Angle Ellipsometry (VASE) measurements were performed on the Ag/GO/Au structure. An interesting behavior of the GO deposited on magnetron-sputtered silver with the formation of Ag nanostructures on top of the GO layer is reported. In addition to typical GO bands, Micro-Raman analysis reveals peaks such as the 1478 cm−1 band, indicating a transition from sp3 to sp2 hybridization, confirming the partial reduction of GO. Additionally, calculations based on effective medium theory (EMT) highlight the potential of Ag/GO structures in hyperbolic metamaterials for photonics. The medium exhibits dielectric behavior up to 323 nm, transitions to type I HMM between 323 and 400 nm and undergoes an Epsilon Near Zero and Pole (ENZP) transition at 400 nm, followed by type II HMM behavior.
Staining Analysis of Resin Cements and Their Effects on Colour and Translucency Changes in Lithium Disilicate Veneers
Authors: Miletic Vesna , Pour Ronagh Asana
Published: January 2025

This study evaluated the colour and translucency changes in resin cements and lithium disilicate veneer restorations, as well as the sorption and solubility of cements after staining. Four resin cements (G-CEM ONE, RelyX Universal, Panavia V5, Variolink Esthetic) were tested. Cylindrical specimens and LiSi veneer restorations cemented to a G-aenial Universal Injectable dentine base (N = 10/group) were stained in black tea for 72 h. Changes in colour (∆E00) and the translucency parameter (∆TP00) were analyzed using a spectrophotometer, while sorption and solubility were calculated via mass/volume formulae. G-Cem and RelyX exhibited significantly lower ∆E00 than Variolink and Panavia (p < 0.001), while RelyX uniquely showed increased ∆TP00 (p < 0.001). The ∆E00 of cemented veneers ranged from 2.7 ± 0.5 (G-Cem) to 3.9 ± 0.7 (Panavia), with decreased translucency after staining across groups (p > 0.05). The initial TP positively correlated with the ∆E00 of both cements and veneer restorations, while the ∆E00 of cements correlated with that of veneer restorations. RelyX had the highest sorption, and Variolink showed the highest solubility, though neither correlated with colour changes. Resin cements influenced colour changes in veneer restorations post-staining, with colour differences associated with initial cement translucency but independent of sorption and solubility.
Strategies for the Transformation of Waste Cooking Oils into High-Value Products: A Critical Review
Authors: Beghetto Valentina
Published: January 2025

Waste cooking oils (WCOs) are generated globally from households, the hospitality industry, and other sectors. Presently, WCOs are mainly employed as feedstock for biodiesel and energy production, strongly depending on the availability of WCOs, which are often imported from other countries. The objective of this review is to give an overall comprehensive panorama of the impacts, regulations, and restrictions affecting WCOs, and their possible uses for producing high-value products, such as bio lubricants, bio surfactants, polymer additives, road and construction additives, and bio solvents. Interestingly, many reviews are reported in the literature that address the use of WCOs, but a comprehensive review of the topic is missing. Published studies, industry reports, and regulatory documents were examined to identify trends, challenges, production statistics, environmental impacts, current regulations, and uses for high-value polymer production. The data collected show that WCOs hold immense potential as renewable resources for sustainable industrial applications that are in line with global carbon neutrality goals and circular economy principles. However, achieving this shift requires addressing regulatory gaps, enhancing collection systems, and optimizing conversion technologies. This comprehensive review underlines the need for collaborative efforts among policymakers, industry stakeholders, and researchers to maximize the potential of WCOs and contribute to sustainable development.
Fracture Resistance of Glass-Fiber-Reinforced Direct Restorations on Endodontically Treated Molar Teeth with Furcal Perforation
Authors: Hazar Ecehan , Hazar Ahmet
Published: January 2025

This in vitro study evaluated short-fiber-reinforced composite materials and fiber-reinforced restorations of endodontically treated molars with furcal perforation. The endodontic treatment and mesio-occlusal–distal cavity preparation of 126 two-rooted mandibular third molars were performed. Eighteen non-perforated teeth were restored with resin composite as the control group. Furcal perforations and repair were performed on 108 teeth that were divided into six experimental groups: resin composite (RC), everX Flow (EXF), everX Posterior (EXP), Bioblock (BB), modified transfixed (MT), and horizontal glass-fiber (HGF) groups (n = 18). Fracture resistance tests were performed at an angle of 30◦ using a universal testing machine under static loading, and fracture patterns were classified. Welch’s analysis of variance, Pearson chi-square, and Tamhane post hoc tests (p = 0.05) were used to analyze the data (p = 0.05). The highest fracture resistance values were seen with the HGF (596.305 N), followed by MT (540.365 N), BB (477.906 N), EXP (476.647 N), EXF (414.462 N), control (413.811 N), and RC (335.325 N) groups (p < 0.001). There was no significant difference between the BB and EXP groups or between the EXF and control groups (p > 0.05). In terms of the dominant fracture pattern, the HGF and MT groups were repairable and possibly repairable, whereas the control, RC, and EXP groups were unrepairable. The EXF and BB groups were almost equally divided between possibly repairable and unrepairable. Restorations using horizontal fiber techniques and short-fiber-reinforced materials increased the fracture resistance of endodontically treated teeth with furcal perforation.
Does Genetic Predisposition Explain the “Immigrant Health Paradox”? Evidence for Non-Hispanic White Older Adults in the U.S.
Authors: Gubernskaya Zoya , Conley Dalton
Published: January 2025

This study uses data from the 2006–2012 Health and Retirement Study (HRS) genetic sample (N = 11,667) to explore the “immigrant health paradox” from a novel perspective by examining the nativity differences in genetic predisposition to health-related outcomes. Polygenic indices (PGIs) were used to evaluate whether older non-Hispanic white foreign-born individuals have genotypes that predispose them to better health profiles compared to their U.S.-born counterparts. The results show an immigrant advantage with respect to genetic predisposition to cognitive function, BMI, and smoking frequency. There are no significant differences in genetic predisposition to height, smoking initiation, and depression. Including respective PGIs in multinomial regression models partially explains an immigrant advantage with respect to cognitive function and obesity. The findings are consistent with the “healthy immigrant effect” or selective migration of individuals with a favorable genetic predisposition to health as one of the explanations of the immigrant health paradox.
Insights from the Last Decade in Computational Fluid Dynamics (CFD) Design and Performance Enhancement of Darrieus Wind Turbines
Authors: Fertahi Saïf ed-Dîn , Rehman Shafiqur , Benini Ernesto , Lahrech Khadija , Samaouali Abderrahim , Arbaoui Asmae , Kadiri Imad , Agounoun Rachid
Published: January 2025

This review provides an analysis of advancements in the design and performance assessment of Darrieus wind turbines over the past decade, with a focus on the contributions of computational fluid dynamics (CFD) to this field. The primary objective is to present insights from studies conducted between 2014 and 2024, emphasizing the enhancement of Darrieus wind turbine performance through various technological innovations. The research methodology employed for this review includes a critical analysis of published articles related to Darrieus turbines. The focus on the period from 2014 to 2024 was considered to highlight recent parametric CFD studies on Darrieus turbines, avoiding overlap with previously published reviews and maintaining originality relative to existing review works in the literature. By synthesizing a collection of articles, the review discusses a wide range of recent investigations utilizing CFD modeling techniques, including both 2D and 3D simulations. These studies predominantly utilize the “Ansys-Fluent” V12.0 and “STAR CCM+” V9.02 solvers to evaluate the aerodynamic performance of Darrieus rotors. Technological advancements focus on modifying the geometry of Darrieus, including alterations to blade profiles, chord length, rotor diameter, number of blades, turbine height, rotor solidity, and the integration of multiple rotors in various configurations. Additionally, the incorporation of flow deflectors, the use of advanced blade shapes, such as V-shaped or twisted blades, and the application of an opening ratio on the blades are explored to enhance rotor efficiency. The review highlights the significant impact of these geometric modifications on key performance metrics, particularly the moment and power coefficients. A dedicated section presents CFD-derived visualizations, including vorticity fields, turbulence contours illustrated through the Q-criterion, velocity vectors, and dynamic pressure contours. These visualizations provide a description of the flow structures around the modified Darrieus rotors. Moreover, the review includes an analysis of the dynamic performance curves of Darrieus, which show improvements resulting from the modifications of the baseline design. This analysis covers the evolution of pressure coefficients, moment coefficients, and the increased power output of Darrieus.
The Discourse on the Marxist Study of Religion in the New Era in the PRC: An Outsider’s Perspective
Authors: Wengenmayr Katja
Published: January 2025

This paper contributes to the intercultural understanding of religious studies in East Asia by examining their discursive framework within the Chinese context. It analyzes the academic discourse on religious studies in the PRC, particularly debates on atheism and the Marxist study of religion. In 2021, President Xi Jinping emphasized the importance of aligning religious studies with Marxist principles, sparking renewed debate on the field’s orientation. This paper examines the responses of religious studies scholars to state directives. It illustrates how the reframing of the discipline and reinterpretations of the Marxist view on religion serve as strategies employed by scholars to answer “the call” of the official discourse. The significant representation of scholars promoting atheism in the political sphere further aligns religious studies with official discourse, narrowing the discursive space for other theoretical approaches toward religion.
Quantum-Inspired Sliding-Mode Control to Enhance the Precision and Energy Efficiency of an Articulated Industrial Robotic Arm
Authors: Fazilat Mehdi , Zioui Nadjet
Published: January 2025

Maintaining precise and robust control in robotic systems, particularly those with nonlinear dynamics and external disturbances, is a significant challenge in robotics. Sliding-mode control (SMC) is a widely used technique to tackle these issues; however, it is plagued by chattering and computational complexity, which limit its effectiveness in high-precision environments. This study aims to develop and assess a quantum-inspired sliding-mode control (QSMC) strategy to enhance the SMC’s robustness, precision, and computational efficiency, specifically in controlling a six-jointed articulated robotic arm. The methodology involves creating a comprehensive kinematic and dynamic model of the robot, followed by implementing both classic SMC and the proposed Q-SMC in a comparative way. The simulation results confirm that the Q-SMC method outperforms the classic SMC, particularly in reducing chattering, improving tracking accuracy, and decreasing energy consumption by approximately 3.79%. These findings suggest that the Q-SMC technique provides a promising alternative to classical control methods, with potential applications in tasks requiring high precision and efficient robotic manipulations.
Detecting the Phenological Threshold to Assess the Grassland Restoration in the Nanling Mountain Area of China
Authors: Liu Zhenhuan , Li Sujuan , Chi Yueteng
Published: January 2025

The dynamics of vegetation changes and phenology serve as key indicators of interannual changes in vegetation productivity. Monitoring the changes in the Nanling grassland ecosystem using the remote sensing vegetation index is crucial for the rational development, utilization, and protection of these grassland resources. Grasslands in the hilly areas of southern China’s middle and low mountains have a high restoration efficiency due to the favorable combination of water and temperature conditions. However, the dynamic adaptation process of grassland restoration under the combined effects of climate change and human activities remains unclear. The aim of this study was to conduct continuous phenological monitoring of the Nanling grassland ecosystem, and evaluate its seasonal characteristics, trends, and the thresholds for grassland changes. The Normalized Difference Phenology Index (NDPI) values of Nanling Mountains’ grasslands from 2000 to 2021 was calculated using MOD09A1 images from the Google Earth Engine (GEE) platform. The Savitzky–Golay filter and Mann–Kendall test were applied for time series smoothing and trend analysis, and growing seasons were extracted annually using Seasonal Trend Decomposition and LOESS. A segmented regression method was then employed to detect the thresholds for grassland ecosystem restoration based on phenology and grassland cover percentage. The results showed that (1) the NDPI values increased significantly (p < 0.01) across all grassland patches, particularly in the southeast, with a notable rise from 2010 to 2014, and following an eastern to western to central trend mutation sequence. (2) the annual lower and upper NDPI thresholds of the grasslands were 0.005~0.167 and 0.572~0.727, which mainly occurred in January–March and June–September, respectively. (3) Most of the time series in the same periods showed increasing trends, with the growing season length varying from 188 to 247 days. (4) The overall potential productivity of the Nanling grassland improved. (5) The restoration of the mountain grasslands was significantly associated with the grassland coverage and mean NDPI values, with a key threshold identified at a mean NDPI value of 0.5 for 2.1% grassland coverage. This study indicates that to ensure the sustainable development and conservation of grassland ecosystems, targeted management strategies should be implemented, particularly in regions where human factors significantly influence grassland productivity fluctuations.
HMCNet: A Hybrid Mamba–CNN UNet for Infrared Small Target Detection
Authors: Li Bolin , Rao Peng , Su Yueqi , Chen Xin
Published: January 2025

Using infrared technology to accurately detect small weak targets is crucial in various fields, such as reconnaissance and security. However, the infrared detection of small weak targets is challenged by complex backgrounds, tiny target sizes, and low signal-to-noise ratios, which significantly increase the difficulty of detection. Early studies in this domain typically utilized manually designed feature-extraction methods that performed inadequately in the presence of complex backgrounds. While advancements in deep learning have spurred rapid progress in this field, with CNN models effectively enhancing the detection performance, the problem of small weak target features being lost persists. HMCNet, which employs a hybrid architecture combining a state space model and a CNN, is proposed in this paper; its hybrid architecture demonstrates the capacity to extract the local features and model the global context, facilitating superior suppression of complex backgrounds and detection of small weak targets. Our experimental results on the public IRSTD-1k dataset and our own MISTD dataset indicate that, compared to the current mainstream methods, the method proposed achieves better detection accuracy while maintaining high-speed inference capabilities, thus validating the rationality and effectiveness of this research.