bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF LIFESTYLE IN MEDIATING THE EFFECT OF USING SOCIAL MEDIA ON SELF-CONCEPT IN STUDENTS FROM TIMOR LESTE IN DKI JAKARTA
Authors:   Universitas Persada Indonesia YAI, Jakarta Indonesia., Manuel Alves Guterres Aderito
Published: November 2023

Advances in technology today have a significant impact on everyday life. Many people think of the use of technology as the creation and application of instruments, devices, materials, and methods that assist people in solving problems. This research was conducted with the aim of looking at the effect of using social media on self-concept with lifestyle as a mediating variable for students from Timor Leste in DKI Jakarta. The population in this study were students from Timor Leste who were in Jakarta, with a sample of 50 respondents. The data analysis method used is the structural equation model (SEM) using the SmartPLS version 3.2.9. The results of the study found that the use of social media had a positive and significant effect on the lifestyle of students from Timor Leste in Jakarta. Then it was also found that lifestyle has a positive and significant influence on the self-concept of students from Timor Leste in Jakarta. Finally, it is known that lifestyle is able to mediate the effect of using social media on the self-concept of students from Timor Leste in Jakarta.
POUR UNE JUSTICE COMMUTATIVE DANS LES PLANS NATIONAUX DE DEVELOPPEMENT
Authors:   Universite de Kara, TOGOFaculte des Lettres et Sciences Humaines (FLESH)Departement de Philosophie., Arinte Touko
Published: November 2023

After the period of structural adjustment, whichhad no positive impact on development or national finances, we are now in the era of National Development Plans. At the risk of these national plans telescoping and scuttlingeachother, giventhat countries in the same zone produce the samethings and have the samenaturalresources, wewould like to use ourwork to propose an inclusive regional plan in the light of the commutative justice advocated by Thomas Aquinas and Aristotle. This regionaldevelopment plan willtakeintoaccount not only the specificity of each country, but also the region as a whole, so as not to give in to the manipulations of the usualdivide-and-rulecommonalities. Wewill focus on three main areas. These are the ecological question, economic and political inclusion, and the security question. This plan must bedrawn up in the light of commutative justice, a justice thatfocuses on the distribution of goodsaccording to equivalence, where nature obeys the order of chance. In fact, the distribution of wealth, births and social affiliations from the outsetis the result of chance, and it can neverbe right thatwhat nature gives for free shouldbekept for oneself. A regional plan for inclusive developmentwouldbe the place to repairwhat nature has disposed of at random.
SINGLE COMPLETE DENTURE WITH THE INCORPORATION OF A DENTURE TITANIUM MESH INTO THE DENTURE BASE AND METAL OCCLUSAL STOPS: A CLINICAL REPORT
Authors:   Postgraduate Student at Late Shri. Yashwantrao Chavan Memorial Medical and Rural Development Foundations Dental College and Hospital, Ahmednagar., D. Khairnar Chetan , S. Sakpal Omkar ,   Assistant Professor at Late Shri. Yashwantrao Chavan Memorial Medical and Rural Development Foundations Dental College and Hospital, Ahmednagar.
Published: November 2023

The single complete denture is a complex prosthetic treatment that necessitates a comprehensive understanding of prosthetic rehabilitation for the loss of natural dentition. One of the main challenges encountered during the provision of successful single complete denture treatment is the repeated fracture of the prosthesis. To address this issue, incorporating denture titanium mesh into the denture base is proposed as an ideal solution to strengthen the prosthesis. Another common problem is the wearing off of acrylic denture teeth when opposing natural dentition. To mitigate this issue, the use of metal occlusal stops in the single complete denture is recommended. This clinical report presents a case of successful rehabilitation of an edentulous maxillary ridge using denture titanium mesh incorporated into the heat-cure acrylic denture base material, along with metal occlusal stops in a patient with an edentulous maxillary jaw.
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME: A CASE REPORT
Authors:   Service De Pediatrie, Chu Hassan II De Fes., Moudden S.El , Chaouki S. ,   Service De Pediatrie, Chu Hassan II De Fes., Abourazzak S. ,   Service De Pediatrie, Chu Hassan II De Fes., Hbibi M. ,   Service De Pediatrie, Chu Hassan II De Fes., Hida M. ,   Service De Pediatrie, Chu Hassan II De Fes.
Published: November 2023

Autoimmunelymphoproliferative syndrome (ALPS), a rare geneticdisorder, is a non-malignant, non-infectiouslymphoproliferationthatalters immune system homeostasis by altering FAS-mediated lymphocyte apoptosis. In the past few years, the diagnosis of ALPS wasalwaysconfusedwithotheridiopathicautoimmune pathologies such as Evans syndrome (which combines autoimmunehemolyticanemia and idiopathicthrombocytosis), histyocytosis or systemic lupus erythematosus. In this article, wepresenta case of a childaged 2 years and 7 months, whopresentedwithprolongedfeverassociatedwith a tumor syndrome consisting of polyadenopathy, hepatomegaly, splenomegaly and recurrentcytopenia. Aftereliminatingother diagnoses, the diagnosis of autoimmunelymphoproliferative syndrome wasretained by the demonstration of the FAS mutation on geneticstudy.
ISCHEMIC HEART DISEASE AND DIAGNOSTIC CORONARY ANGIOGRAPHYEPIDEMIOLOGICAL DATA AND FEMORAL VS. RADIAL APPROACH : A SERIES OF 100 CASES
Authors: M.A. Skandaji , M. Ibenchekroun , N. Fellat
Published: November 2023

Introduction: The use of radial access for coronary interventions offers advantages such as reduced access-site bleeding and improved patient comfort. However, the learning curve for radial access and conflicting findings regarding outcomes in previous studies have influenced its widespread adoption. This study aimed to comprehensively assess the effects of radial access compared to femoral access in patients with ischemic heart disease. Materials and Methods: A retrospective analysis was conducted on 100 patients who underwent diagnostic coronary angiography at Ibn Sina University Hospital. Patient demographics, clinical indications, angiographic data, and complications were compared between the radial and femoral access groups. Statistical analysis was performed using SPSS software. Results: The study included 45 patients in each group, with an average age of 63 years. Male patients accounted for 67% of the study population. The most common indications for coronary angiography were acute coronary syndrome (41%), heart failure (28%), stable angina (17%), and unstable angina (10%). The angiographic findings revealed that 79% of patients had pathological coronary angiograms, with bi-troncular involvement being the most prevalent (40.5%). Vascular complications occurred in 4% of cases, including a femoral fistula requiring vascular surgery. Conclusion: The study findings aligned with previous research, demonstrating that radial access resulted in fewer vascular and hemorrhagic complications compared to the femoral approach. However, the radial route presented challenges such as a longer procedural duration and increased radiation exposure. The decision between radial and femoral access should consider the operators experience, patient preference, and clinical factors.
SPONTANEOUSREMOVALOFPLACENTAORMANUALREMOVALOFPLACENTA:WHICHISMOREBENEFICIALTOTHEPATIENTSPOST-OPERATIVELY:
Authors: Kishore Kumar M. , Kumar Shery Angel Raja
Published: November 2023

Aim:Toassesswhichmethodofplacentaremovalhasmorebeneficialeffects,spontaneousremovalormanualremovalandadheretopracticesthatbenefitthepatient. Design:RETROSPECTIVECOHORTSTUDY Methodology: SampleSize:100 Inclusioncriteria: PostnatalpatientsProcedure:Thisstudyisaretrospectivecohortstudy.ThestudypopulationwillbepostnatalpatientswhodeliveredinChettinadHospital. After getting informed consent, the procedure will be explained thoroughly to the participantsand only the participants who are willing to take part in the study will be selected. Theparticipantswereobservedonanoutpatientbasisandthosewhowereadmittedinthepostnatalward. Parturients undergoing cesarean delivery were prospectively randomized to have theplacenta removed manually or spontaneously. Patients were excluded from participation if theyhad received intrapartum prophylactic antibiotics or had been determined to havechorioamnionitis. After delivery of the infant, women in the manual group had the placentaextracted by the primary surgeon, whereas women in the spontaneous group had the placentadelivered by gentle traction on the umbilical cord. All study subjects received perioperativeprophylactic antibiotics. Their pre operative and post operative reports were analyzed forHaemoglobin counts, their course of antibiotics and days of antibiotics taken post operativelywastakenintoconsideration,symptomssuchasDizziness,palpitations,headacheTirednessorweakness were asked to the patients and their complete blood counts report, urine routinereportswerecollectedtobecomparedpreandpostoperatively. Thisstudyisainvasivestudy. StudyDuration:2months(4/10/2023-04/12/2023)Results: A total of 100 women were enrolled in the investigation, with 48 assigned to the manual removalgroup and 52 allocated to have spontaneous removal. There were no statistically significantdifferencesinmeangestationalage,frequencyordurationofrupturedmembranes,frequencyordurationoflabor,ormeannumberofvaginalexaminationsbetweenthetwostudygroups. Postoperative infections occurred in 5 of 52 women in the spontaneous delivery groupcomparedwith12of48womeninwhichtheplacentawasmanuallyextracted.Subsetanalysisof patients delivered with ruptured membranes similarly demonstrated a statistically significantreduction in the incidence of postoperative infections with spontaneous placental removalcompared with manual extraction There was a similar trend toward a reduction in post deliveryinfectionsassociatedwithspontaneousplacentalremovalinwomenwithintactmembranes. Conclusion:Spontaneous delivery of the placenta after cesarean delivery is associated with a decrease intheincidenceofpostcesareaninfectionsandanemicsymptomscomparedtomanualremovaloftheplacenta.
A rare case of cutaneous mastocytosis in pediatric practice
Authors: Kulakova G. A. , Solovieva N. A. , Volgina S. Ya. , Kurmaeva E. A. , Kalinina O. V. , Kaiumova I. I. , Zarva L. A.
Published: November 2023

Mastocytosis belongs to a group of rare diseases in which there is a pathological accumulation of mast cells in tissues. In childhood, it is more often limited to skin lesions. A clinical case of a bullous form of severe cutaneous mastocytosis, with the onset of the disease at 3.5 months, is presented. Cutaneous manifestations with a positive Darier–Unna symptom and a high level of tryptase in the blood, the exclusion of systemic lesions allowed diagnosing cutaneous mastocytosis and choosing treatment tactics.
Current insight into klebsiella infection in children
Authors: Nikolaeva I. V. , Semenova D. R. , Shaikhieva G. S.
Published: November 2023

Klebsiella pneumoniae is an important causative agent of nosocomial and community-acquired infections in children. The relevance of Klebsiella infection has increased in recent years due to the spread of multiresistant and hypervirulent strains that can cause invasive forms of infection (sepsis, meningitis, liver abscess, etc.). Strains of Kl. pneumoniae, producing extended-spectrum β-lactamase (ESBL), as well as carbapenem-resistant strains, are the cause of nosocomial outbreaks with high mortality. The choice of antibacterial drugs for the treatment of invasive forms of infection is limited and depends on the spectrum of sensitivity to antimicrobial drugs of Klebsiella clinical isolates circulating in the hospital and the age of the child. Due to the high rate of ESBL production, carbapenems are the drugs of choice in the empirical therapy of invasive forms of infection.
Analysis of complications of neurogenic bladder dysfunction in children
Authors: Morozov V. I. , Nuritdinov I. N. , Morozov D. V.
Published: November 2023

Dysfunction of the lower urinary tract is a fairly common consequence of perinatal lesions of the nervous system. Dysfunction of the bladder and muscles of the urogenital diaphragm in this group of children can be accompanied by severe urodynamic disorders and, in some cases, can lead to complications such as chronic recurrent urinary tract infection, vesicoureteral reflux, nephrosclerosis, kidney atrophy, chronic renal failure. Purpose. To study uronephrological complications in children with various forms of neurogenic bladder dysfunction and suggest methods for their prevention and pathogenetic treatment. Material and methods. 67 children with neurogenic bladder dysfunction were examined. All children underwent comprehensive uronephrological and neurological diagnostics using objective neuroimaging, electrophysiological and functional research methods. Results. Complications leading to somatic health disorders in patients were diagnosed. These included chronic cystitis — in 13 (19.4%) patients, chronic pyelonephritis — in 57 (85.1%), vesicoureteral reflux — in 25 (37.3%), chronic renal failure — in 8 (11.9%) children. Therapy for neurogenic bladder dysfunction consisted of basic therapy of the central nervous system lesion, as well as symptomatic therapy aimed at normalizing the functional state of the bladder. In the vast majority of cases of neurogenic bladder dysfunction complications, their relief occurred within a year in the process of curing the underlying disease. In some cases, in children with severe neurological disorders (myelodysplasia, meningoradiculocele), along with medication and physiotherapy, surgical manipulations (periodic bladder catheterization) and surgical interventions (epicystostomy) were performed. Conclusion. In children with detrusor hyperreflexia and mild «high» lesions of the nervous system, clinical symptoms of neurogenic bladder dysfunction were usually noted, worsening only their quality of life. In children with a significant neurological deficit and a rather severe lesion of the lumbosacral spinal cord, complications developed that worsened the somatic health of this group of patients.
A case of Kaposi’s varicelliform eruption in a 4-month-old child
Authors: Fatkullina G. R. , Anokhin V. A. , Safina F. M. , Emel’yanova P. N. , Bakhtiguzina T. K. , Sabitova A. M.
Published: November 2023

It is well known that herpesviruses are pantropic, hence herpetic infections are characterized by a diverse clinical pattern. Often one of the syndromes of various «herpetic nosologic forms» is the exanthema syndrome. Traditionally, this is a vesicular rash accompanying the infection caused by herpes simplex virus, which occupies a fairly limited area, but the rashes can be completely different in nature, quantity, and localization. The article discusses a relatively rare variant of herpetic infection, called: Kaposi’s varicelliform eruption (eczema herpeticum), or Kaposi–Juliusberg varioliform pustulosis, characterized by the severity of clinical manifestations, often an unfavorable outcome, diagnostic and therapeutic difficulties. Photo documents of the dynamics of the skin process and laboratory parameters against the background of antiviral therapy are presented.
Integrating local solar energy and water recovery: Operating experiences of a systemic approach
Authors: Gillblad Thomas , Olsson Gustaf
Published: November 2023

The key message is the importance of a systemic approach to handling water and energy together, both in design and in operation. The paper demonstrates how renewable energy, solar photovoltaic (PV) and solar thermal, in combination with a small nutrient removal plant, provides a reliable solution for small-scale decentralized water recovery operations. The system is automated and can operate outside the power grid and is designed to be a fully circular system in terms of both energy and water. The system has been installed on an island in the archipelago outside Stockholm, Sweden, to replace an old-fashioned septic tank. The effluent must satisfy rather strict effluent quality criteria for the Baltic Sea. The paper describes design considerations, instrumentation aspects, automation features, and operation experiences.
Comparative analysis of gridded rainfall datasets over the Bagmati river basin, India
Authors: Kumar Ajit , Singh Vivekanand
Published: November 2023

In this study, three high-resolution gridded rainfall datasets, viz., Integrated Multi-Satellite Retrievals for Global Precipitation Measurement (IMERG), Modern-Era Retrospective Analysis for Research and Applications 2 (MERRA-2), and Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN) have been collected, analyzed, and compared against the ground-based observed rain gauge datasets of Indian Meteorological Department (IMD) of the Bagmati river basin from 2001 to 2014 in the Bihar State of India. Comparison analyses were performed at daily, monthly, seasonal, and annual time scales. Various statistical parameters, contingency tests, trend analysis, and rainfall anomaly index were used for comparison of datasets. Though MERRA-2 had the highest probability of detection (POD) and lowest false alarm ratio (FAR), analysis showed that IMERG data were closely matching with the observed data, whereas MERRA-2 and PERSIANN underestimated the extreme values. For the monthly scale, again IMERG had the most optimal Coefficient of Determination (R2) and Nash-Sutcliffe Efficiency (NSE) values. IMERG also performed well in detecting rainfall trends and identifying wet and dry years. Overall, IMERG was the most suitable dataset at all time scales for future studies in the basin.
Influence of seasonality on the physical-chemical properties of water for human consumption by residents of floating villages in the interior of the Amazon
Authors: Corrêa Lima Chamy Michel Nasser , Guimarães Patrícia dos Santos , Poveda Vanessa de Brito
Published: November 2023

The aim of this study was to evaluate the physicochemical properties of the water consumed by residents of floating houses and the influence of the hydrological cycles of flood and drought on these parameters. The sample consisted of 44 floating domestic units per hydrological cycle, located on the edges of the cities of Codajás, Coari and Tefé. Sociodemographic data and data related to water consumption and storage habits were collected using a semi-structured questionnaire. Water samples were collected and analyzed in accordance with the Standard Methods for the Examination of Water and Wastewater. Data were analyzed in the dry and flood hydrological phases and compared to the maximum values allowed by Ordinance GM/MS No. 888/2021. The results showed that the nitrite, manganese and free residual chlorine parameters were not in accordance with the legislation. Manganese (p = .035) and aluminum (p < .001) showed significant differences between the hydrological phases. The considerable increase in aluminum content during the flood period, even though it was within the limits of the ordinance, was also highlighted. Accordingly, even with periodic control by the supply companies, it is important to monitor the water at the point of consumption of the population.
An Outlook of the Structure Activity Relationship (SAR) of Naphthalimide Derivatives
as Anticancer Agents
Authors: Bhat Aeyaz Ahmad
Published: November 2023

The efficacy of drugs against cancer in clinical settings may be limited due to pharmacokinetic issues,
side effects and the emergence of drug resistance. However, a class of anticancer drugs known as naphthalimides
have proven to be very effective. These derivatives have demonstrated to be effective in treating different types of
cancers and exhibit strong DNA binding affinity. The anticancer properties of the naphthalimide derivatives allow
them to target a number of cancer cell lines. Researchers have investigated the anticancer activity of numerous
naphthalimide derivatives, such as heterocyclic fused, non-fused substituted, metal-substituted and carboxamide
derivatives. Surprisingly, some derivatives demonstrate greater activity than the reference norms, such as cisplatin,
amonafide, mitonafide and others and are selective against many cell lines. The primary objective of this
research is to comprehend the effects of various substitution patterns on the structure-activity relationship (SAR)
of these derivatives and the instances in which they enhance or reduce this biological activity.
Cheminformatics Screening of Phytochemicals Targeting Diverse Potential
Receptors to Elicit Antiviral Properties
Authors: Kumar Ravi , Gupta Garima , Mohan Aditi , Gupta Madhu
Published: November 2023

Objective:

Recently, the COVID-19 (coronavirus disease) pandemic caused by SARSCoV-2 (severe acute respiratory syndrome coronavirus) gave rise to a public health emergency
worldwide. Similarly, other viruses like HIV (Human Immunodeficiency Virus)/AIDS (acquired
immunodeficiency syndrome), Zika, Ebola, and Influenza and their mutants have called for an urgent
need for a Broad-spectrum antiviral drug, inhibiting the infection by targeting the common essential
components of different viruses.

Methods:

Based on ancient medicinal knowledge, we made an attempt through molecular docking
analysis to explore different phytochemical compounds against well-recognized viral receptors.

Results:

A total of 29 phytochemicals were virtually examined against 4 targets essential in the life
cycle of viral infection: CD147 (Cluster of Differentiation 147), CD209L (Cluster of Differentiation
209 Lectin), eIF4A (Eukaryotic Initiation Factor 4A), and RdRp (RNA-dependent RNA polymerase). Providentially, Berbamine was identified as the best-hit lead molecule based on binding energies, conventional hydrogen bonding numbers, and non-covalent interactions. It exhibited binding
energies as -8.3 kcal/mol with CD147, -8.2 kcal/mol with CD209L, -9.5 kcal/mol with eIF4A, and -
10.5 kcal/mol with RdRp. Additionally, in-silico drug likeliness (Lipinski’s rule) and ADME studies
depict high bioavailability and gastrointestinal absorption and follow Lipinski’s rule.

Conclusion:

The data presented by our study exemplify phytochemicals from the selected plants that
could target conserved viral components shared across multiple viruses. Berbamine can be designed
as a possible drug to target Broad-Spectrum viruses, limiting the effectiveness of different viruses.
MgO-based cements – Current status and opportunities
Authors: Bernard Ellina , Nguyen Hoang , Kawashima Shiho , Lothenbach Barbara , Manzano Hegoi , Provis John , Scott Allan , Unluer Cise , Winnefeld Frank , Kinnunen Paivo
Published: November 2023

The cement industry is a major contributor to the anthropogenic CO2 emissions, with about 8% of all emissions coming from this sector. The global cement and concrete association has set a goal to achieve net-zero CO2 concrete by 2050, with 45% of the reduction coming from alternatives to Portland cement, substitution, and carbon capture and utilization/storage (CCU/S) approaches. Magnesia-based cements offer a conceivable solution to this problem due to their potential for low-to-negative CO2 emissions (CCU/S) but also being alternatives to Portland cement. The sources of magnesia can come from magnesium silicates or desalination brines which are carbon free for raw-material-related emissions (cf. carbonated rocks). This opens up possibilities for low or even net-negative carbon emissions. However, research on magnesia-based cements is still in its early stages.

In this paper, we summarize the current understanding of different MgO-based cements and their chemistries: magnesia oxysulfate cement, magnesia oxychloride cement, magnesia carbonate cement, and magnesia silicate cement. We also discuss relevant research needed for MgO-based cements and concretes including the issues relating to the low pH of these cements and suitability of steel reinforcement. Alternatives reinforcements, suitable admixtures, and durability studies are the most needed for the further development of MgO-based concretes to achieve a radical CO2 reduction in this industry. Additionally, techno-economic and life cycle assessments are also needed to assess the competition of raw materials and the produced binder or concrete with other solutions. Overall, magnesia-based cements are a promising emerging technology that requires further research and development to realize their potential in reducing CO2 emissions in the construction industry.
Efficient Industrial Wastewater and Leachate Evaporation Utilizing Heat Localization in Porous Media
Authors: Zaro Abdel , Jones Spencer , Languri Ethan
Published: November 2023

In this paper, an efficient industrial wastewater and leachate evaporation method is proposed and tested experimentally. The goal of this study is to investigate whether the addition of a carbon foam (CF) porous layer can lead to energy savings by evaporating more water mass per unit of energy input. The standard boiling evaporator layout was redesigned by placing the heating element in the upper region of the tank and CF underneath the heat source. The CF purposed to localize the energy in an area by the water's surface and minimize conduction heat losses to the rest of the water. A 90.2% reduction in energy lost to regions outside of the CF isolated control volume, specifically during the evaporator preheating process was observed with the addition of 100 Pores Per Inch (PPI) CF. In addition, a reduction in evaporative energy intensity was observed yielding results of 3.344 , 3.441 , and 3.644 for the 100 PPI, 45 PPI, and 10 PPI tests, respectively. This new evaporation design provides a more energy- and cost-efficient method for reducing the volume of various industrial wastewater and leachate concentrations onsite.
Net Zero Corridors: A Case Study Approach from Perth, Australia to Decarbonize Urban Power and Transport
Authors: Newman Peter , Verschuer Marie
Published: November 2023

The transition to net zero cities is a pivotal challenge in the face of climate change. This research introduces a novel methodology termed "Net Zero Corridors," which emphasizes a bottom-up approach to decarbonize urban power and transport systems. By focusing on urban corridors, this method integrates distributed power systems with urban transport, offering a localized solution to the broader challenge of urban decarbonization. Drawing from urban fabric theory and urban metabolism data, the study provides insights into the application of various renewable technologies in diverse urban settings, particularly in automobile-dominated cities like Perth, Australia. The net zero city agenda is gathering momentum but faces the issues of transition using either top-down large-scale technologies or bottom-up local-scale technologies that make the most out of the small-scale niches that have been created around renewables. This paper seeks to show how a bottom-up process can be used to start a more effective local scale approach using net zero corridors that can enable more net zero precincts with distributed power systems and at the same time integrate and decarbonize transport systems. Data on Perth are collected and processed to show the economic viability of such net zero projects though they are not yet linked to good transit systems. The net zero corridor concept is demonstrated and shows how to enable a series of net zero precincts that create large steps in removing fossil fuels. These corridor precincts can spread into surrounding suburbs through expanding the local microgrids and their local governance embracing more and more of the city. The net zero corridor concept can be used to transition to net zero cities using bottom-up approaches that link the transformation of power systems and the transformation of transport systems.
Analysis on the Application of Economic Principles in Communication Engineering Projects
Authors: Duan Min
Published: November 2023

With the increasing level of science and technology, the market competition between industries in the real economy has been intensifying, and the prices of production factors such as human capital and raw materials have risen significantly, resulting in higher cost pressure on business projects with low profit margins. Therefore, the use mode of extensive means of production and the irregular financial budgeting of enterprises in the past, to a certain extent, It is necessary to adopt scientific means for effective improvement, so the author takes the communication engineering, which has a wide influence in the real economy industry, as an example to explore the auxiliary role of the principles of enterprise management economics and macroeconomics in the cost and profit of the communication engineering, aiming to contribute to the development of China's industrial economy.
Using the Quine McCluskey Binary Classifier (QMBC) for Heart Disease Prediction
Authors: Namose Prof. M. S.
Published: November 2023

Abstract: In this examine, we awareness on cardiovascular disease, a major worldwide motive of mortality. Researchers use gadget getting to know and records evaluation strategies to enhance the prognosis of this ailment. We introduce a brand new version, the Quine McCluskey Binary Classifier (QMBC), which combines seven extraordinary fashions to efficiently become aware of patients with coronary heart disease. To decorate performance, we appoint feature selection and extraction methods.First, we discover the top 10 relevant features from the dataset the use of Chi-rectangular and ANOVA approaches. We then lessen the dimensionality of the facts with principal aspect analysis, retaining nine essential additives. The QMBC version combines the outputs of the seven fashions to create a truthful rule for predicting coronary heart ailment. The outcomes from the seven fashions are dealt with as unbiased functions, while the target attribute depends on those results. Our proposed QMBC version outperforms present methods, establishing its effectiveness in heart disorder prediction.
A Survey on Campus Companion
Authors: Ramanjinamma Mrs. G
Published: November 2023

Abstract: Chatbots are expert systems designed to understand and respond to user queries in their own language, engaging in conversations similar to human interactions. This chatbot offers two modes of interaction, text and audio, enhancing user experience, particularly in answering through voice messages. College bot project addresses the challenges faced during the academic admission procedure at our institute, especially for parents residing in different locations. The system aims to provide a platform for students and parents to ask questions and resolve doubts using simple English text messages or audio commands, reducing the need for physical visits to the inquiry window.
Calidad y cronotipo del sueño y su relación con la obesidad en población adulta. Revisión bibliográfica narrativa
Authors: Serra Laborde Paula Lucía , Torterolo Pizzuti Caterina , Calvo Pesce María Soledad
Published: November 2023

Introducción: Debido a la alta prevalencia de obesidad a nivel mundial y nacional, y de la incidencia de esta enfermedad en el desarrollo de comorbilidades, estudiar los factores que contribuyan a su desarrollo resulta pertinente. La falta de sueño o el sueño interrumpido pueden estar asociados a la epidemia mundial de la obesidad, y resulta un factor modificable a incluir en su terapéutica. Objetivo: Conocer la evidencia reciente acerca de los mecanismos subyacentes que conforman una posible relación entre la cantidad y/o calidad de sueño con el desarrollo de obesidad en personas adultas. Metodología: Revisión bibliográfica de artículos científicos en plataformas virtuales de bases de datos. Se aplicaron distintos filtros: edad (18 a 64 años), estudios realizados en humanos, texto completo, idioma inglés y español, y publicaciones no mayores a 5 años. Los estudios de evaluación de la calidad de sueño debían haber aplicado el Índice de Calidad de Sueño de Pittsburgh, y los de evaluación del cronotipo el Horne and Ostberg’s Morningness - Eveningness Questionnaire o el Munich Chronotype Questionnaire. Resultados: Individuos con una insuficiente cantidad y/o calidad de sueño fueron asociados con una mayor probabilidad de desarrollar obesidad. Los principales mecanismos subyacentes encontrados fueron: alteraciones hormonales, metabólicas y un aumento de la ingesta de alimentos principalmente en la noche biológica. Conclusiones: Según la bibliografía seleccionada se concluye que existe evidencia que relaciona la cantidad y/o calidad de sueño con el posible desarrollo de obesidad en población adulta.
Therapeutic measures for COVID-19 and their clinical relevance of hERG channel translocation: A Pharmacodynamic approach
Authors: Satapathy Trilochan , Chandrakar Kunal , Satapathy Abinash , Yadav Neha , Singh Shivangee , Kumar Dheeraj
Published: November 2023

The COVID-19 caused by SARS-CoV-2 poses a massive challenge to the medical system, especially the safe and effective COVID-19 treatment methods, forcing people to look for drugs that may have therapeutic effects as soon as possible. Some old drugs have shown clinical benefits after a few small clinical trials attracting significant attention. Clinically, however, many medications, including those currently shown to be effective against COVID-19, such as Chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir, may cause cardiotoxicity by acting on cardiac potassium channel, hERG channel due to their off-target effect. Blocking of hERG prolongs QT intervals on the electrocardiogram and thus might induce severe ventricular arrhythmias and even sudden cardiac death. Therefore, while focusing on the efficacy of COVID-19 drugs, the fact that they block hERG from causing arrhythmias cannot be ignored. To develop safe and effective drugs, it is necessary to understand the interactions between drugs and hERG channels and the molecular mechanism behind this high affinity. In this review, we focus on the biochemical and molecular mechanistic aspects of related drug blockade in the hERG, trying to provide insights into the QT interval prolongation caused by potential therapeutic drugs for COVID-19 and hope to weigh the risks and benefits when using related drugs.

Keywords: COVID-19; Therapeutic measures; hERG channel; Pharmacodynamic; Vaccines
In-Vitro and In-Silico Approach Distinguish ER-α and HER-2 Antagonistic Properties of Indian Herbal Formulation on Breast Cancer
Authors: Khan Munir , Sur Tapas Kumar , Saha Avijit , Ghosh Chandreyi , Biswas Tuhin K. , Chatterjee Sirshendu , Pandit Srikanta
Published: November 2023

Objectives:  The anticancer effect of an Indian herbal preparation was studied under a cancer cell line, as well as the in silico computational methods that explain the probability of protein ligands binding to ER- α and HER-2 receptors.

Method: The in vitro anticancer activity of Body Revival® suspension (BR) was determined using cytotoxicity tests, cell invasion and migration assays, and metastatic protein expression assays using MCF-7 breast cancer cells. The computational predictive biological method was applied to find out the pharmacodynamic and pharmacokinetic interactions between the active molecules present in the BR and ER- α/and HER-2 of breast cancer.

Results: BR showed significant and dose dependent cytotoxic effects on MCF-7 cells. The 50% effective cytotoxic dose of BR was 34.27µl/ml. It restricted invasion (26%) and migration (28%) of cancer cells than BSA control. MMP-9 and IL-6 concentration were reduced significantly (p<0.001) after treatment. Cucurbitacin B had maximum in silico binding energy score (-7.8) with ER-α, while symconoside B had with HER-2 (-8.4); but, among the other interactions between the two ligands and receptors, withaferin A had the highest affinity (-15.3). Additionally, withaferin A, symconoside A, and symconoside B curcurbitacin A demonstrated bioavailability and fulfilled safety standards.         

Conclusion: Body Revival® showed as a powerful multi-target inhibitor of ER- α and HER-2 that has prospective anticancer action without side effects, and may be useful in the therapy management following a successful trial in breast cancer patients.

Keywords:  Breast cancer, Cytotoxicity, MCF-7, ER- α, HER-2, Herbs, In Silico
The ethanol extract of Muntingia calabura exhibits in vitro antidiabetic potentials by inhibiting carbohydrate digestive enzymes
Authors: Dutta Subhajit , Ramesh C , Madhu A , Pundi Krishna , Sowmya B.A.
Published: November 2023

Objective: The present research study was conducted to investigate in vitro anti-diabetic potentials of ethanol extract of leaves of Muntingia calabura for α-glucosidase and α-amylase inhibitory activities.

Materials & Methods: The leaves of Muntingia calabura were collected and authenticated. dried and powdered. The powdered drug was defatted using petroleum ether and extracted with ethanol. The ethanol extract of Muntingia calabura was subjected to preliminary phytochemical investigation. The in vitro α-glucosidase inhibitory and α-amylase inhibitory properties were determined for the ethanol extract and concentrations of extract required to inhibit absorbance (IC50 values) EEMC were determined.

Results: Significant IC50 values were found in both tests that assessed the inhibitory activity of α-glucosidase and α-amylase, demonstrating the capacity of the ethanol extract of Muntingia calabura to block carbohydrate digesting enzymes and prevent postprandial blood glucose.

Conclusion: The results of the presents investigation recommends that ethanol extract of Muntingia calabura possess significant α-glucosidase and α-amylase inhibitory activity.

Keywords: Antidiabetic activity, Muntingia calabura, α-glucosidase and α-amylase and IC50values.
Screening the statistical impact of some independent variables on the particle size and entrapment efficiency (EE) for the design and development of curcumin-loaded PLGA-Tf nanoparticles
Authors: Verma Deepika , Upadhyaya Kumud
Published: November 2023

The present study provides the insight of statistical aspects of various independent variables like Tf-PLGA Curcumin ratio, stirring speed and emulsifying concentration over dependent variables like particle size and EE of the drug. Design Expert Version 13.1.5 was used to analyse the impact of independent variables over dependent variables.  To study   the effect of intendent variables over particle size, the valve Predicted R² was 0.9701 is in reasonable agreement with the Adjusted R² of 0.9907; i.e., the difference is less than 0.2. indicating that stirring speed have a great impact of particle size. While in another fact also shown the Adeq Precision measures the signal to noise ratio. A ratio greater than 4 is desirable and in respect of that the ratio of 9.630 indicates an adequate signal, i.e. it greatly gives impact on size of nanoparticles. In the case of entrapment efficacy (EE) the Predicted R² of 0.9892 is in reasonable agreement with the Adjusted R² of 0.9910; i.e. the difference is less than 0.2 which support the significance of the study and impact of Tf- PLGA curcumin ratio over EE. Adeq Precision measures the signal to noise ratio. A ratio greater than 4 is desirable but for this study the ratio was calculated as14.989 indicates an adequate signal. Therefore, the two independent variables like, Tf-PLGA Curcumin ratio and stirring speed have significant impact on EE and particle size of nanoparticles.

Keywords: Tf-PLGA Curcumin ratio, stirring speed, EE, particle size, Adjusted R², Predicted R²,. Adeq Precision
Validated Simultaneous Derivative Spectrophotometric Estimation of Azithromycin, Fluconazole and Secnidazole in Bulk and Pharmaceutical Formulation
Authors: Raskar M.A. , Kate P.A. , Mungse S.S. , Godge Ganesh Raosaheb
Published: November 2023

Two simple, sensitive, accurate and precise spectrophotometric methods were developed and validated for the quantitative determination of Azithromycin (AZI), Fluconazole (FLU) and Secnidazole (SEC) in bulk and tablet dosage form. Method A is based on the first-order derivative (D1) and Method B is based on the second-order derivative (D2) spectrophotometric method. In Method A, absorbance was measured at 215nm, 275nm and 333nm being the zero crossing points for AZI, FLU and SEC respectively. In Method B, absorbance was measured at 220nm, 225nm and 211nm being the zero crossing points for AZI, FLU and SEC respectively. For Method A, all three drugs obey Beer’s law in the concentration range 5-30µg/ml for AZI, 5-60 µg/ml for FLU and 5-40 µg/ml for SEC with correlation coefficients 0.995, 0.998 and 0.998 respectively. For Method B, all three drugs obey Beer’s law in the concentration range 5-35 µg/ml for AZI, 5-40 µg/ml for FLU and 5-40 µg/ml for SEC with correlation coefficients 0.995, 0.999 and 0.998 respectively. Both methods can be used for routine analysis of these three drugs in their pharmaceutical dosage form. Results for analysis of both methods were tested and validated for various parameters according to ICH guidelines. 

Keywords: Derivative, Azithromycin, Fluconazole, Secnidazole
Evaluation of Effect of Rosmarinus officinalis L. on Ethylene Glycol Induced Kidney Stone in Rats
Authors: Sahu Swati , Sharma Aakash
Published: November 2023

The present study evaluation of effect of Rosmarinus officinalis L. on ethylene glycol induced kidney stone in rats showed that the ethanolic extract of Rosmarinus officinalis possess the diuretic activity and effective in the treatment of kidney stone. The activity was evaluated against ethylene glycol (0.75%) induced kidney stone in albino rats. Animals were divided into five groups, containing six animals in each. Group I serve as normal control and received regular rat food and drinking water ad libitum. Ethylene glycol (0.75%) in drinking water was feed to Groups II to V for induction of renal calculi for 28 days. Group III received standard anti-urolithiasis drug, cystone (750mg/kg body weight) from 15th to till 35th day. Group IV and V received ethanolic extract of Rosmarinus officinalis at dose of 100mg/kg and 200mg/kg respectively from 15th to till 35th day.

The serum creatinine level, serum urea level, urine calcium level, protein level in urine, serum uric acid was increased and serum calcium level, protein level in serum was decreased in all experimental groups except normal control group after ethylene glycol administration till day 14.

The animals treated on the day 14th with standard drug (Cystone 750mg/kg) and Rosmarinus officinalis extract (100mg/kg and 200mg/kg), were observed significant decreased serum creatinine level, serum urea level, urine calcium level, protein level in urine and serum uric acid and increased serum calcium level, protein level in serum compared to normal control group on the day 28th and 35th.

This indicates that the ethanolic extract of Rosmarinus officinalis (200mg/kg) have protective role against kidney stone.

Keywords: Kidney Stone, Ethanolic extract, Rosmarinus officinalis, Ethylene glycol, uric acid, creatinine.
Assessment of Efficacy and Cost-Effectiveness of Oral and IV Iron Therapy in Chronic Kidney Disease
Authors: Tamilselvan T. , Shanet Nissy Nelson , Senorita Ann Thomas , Shabla KM , Sneha Sathyan
Published: November 2023

Introduction: Long-term iron therapy for anemia in chronic kidney disease patients is creating an economic burden and discontinuation of the treatment. Objective: The purpose of this study was to assess the cost-effectiveness and efficacy of oral and intravenous iron therapy and iron therapy. Methods: the patients were distributed into group 1 and group 2 and were administered with oral and intravenous iron therapy respectively. Baseline hemoglobin and packed cell volume were recorded and subsequently monitored in the next follow-up visit to assess the efficacy of the iron therapy. Results: Among oral therapy, ferric citrate and ferric ascorbate were administered in 61 % and 39% of patients respectively. Among intravenous Iron sucrose and carboxymalotose were administered in 76% and 24% of patients respectively. There was a mean increase of 1.15g/dl and 2g/dl of hemoglobin with oral ferrous ascorbate and intravenous carboxymaltose therapy respectively. Conclusion: Thus, iron sucrose is found to be a cost-effective treatment. Ferrous ascorbate had more effect than ferric citrate and a lower cost compared to ferric citrate. This study revealed that oral ferrous ascorbate treatment is found to be cost-effective in chronic kidney disease with anemia.

Keywords: Iron therapy, cost-effective, anemia, hemoglobin, kidney disease.
Predicting the General Factor of Personality: From Adolescence Through Adulthood
Authors: Dunkel Curt S. , Nedelec Joseph , van der Linden Dimitri
Published: November 2023

It was predicted that interviewers’ rating of the attractiveness of interviewees’ personality would be predictive of interviewees’ self-assessed personality and that this association would primarily be a function of the General Factor of Personality (GFP). Using data from the National Longitudinal Study of Adolescent to Adult Health, ratings based on four interviews occurring across adolescence and into adulthood exhibited small, but reliable, associations with self-assessed personality in early to middle adulthood. Consistent with predictions, the association was primarily a function of the GFP, was independent of interviewee sex and ethnicity, and remained when controlling for the rated candidness of the interviewee. The results are discussed in terms of the GFP social- effectiveness hypotheses.
The Costs of Union Leadership
Authors: Hinshaw John
Published: November 2023

This essay examines why women are underrepresented in the top ranks of unions. Historians have shown that men sidelined women, suggesting the reasons for male dominance were primarily social or cultural. This essay offers novel evidence on family formation and longevity from obituaries and other sources, and a new model that suggests that historians have downplayed the costs of becoming a leader, which are considerable for men and higher still for women. National union leaders lived longer lives than did union members, but local union leaders of both sexes lived considerably shorter ones. Women leaders were significantly less likely than men to have children; an enormous cost. The new model is able to incorporate social and cultural factors that have been well-documented by historians with game theory and evolutionary factors that historians have largely ignored.