bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of letrozole on patients with symptomatic leiomyoma in the reproductive age women
Authors: Prakash Ranjana , Pandey Sushma , Chawla Indu
Published: April 2017

Background: Uterine leiomyoma is a common indication for hysterectomy in India. An effective medical treatment option may reduce hysterectomy associated morbidity. This study was undertaken to evaluate the effect of the Letrozole on patients with symptomatic leiomyoma in the reproductive age women.Methods: Prospective interventional study was conducted on 50 women between 30-45 years of age with menstrual or pressure symptoms on the bowel or urinary system, and having no. Of myoma ≤4 and size of single myoma ≥2 cms in diameter. They received tablet letrozole 5mg/day for 3 month, and effect of the drug on myoma volume and symptomatology were studied. Beside these, effects on uterine volume, ovarian volume, endometrial thickness and side effects of letrozole of any were also studied.Results: Average reduction of myoma volume by 47.68% and uterine volume by 19.58% was seen. Haemoglobin concentration was significantly higher at the end of study. It increased from 9.56g/dl to 10.76g/dl and overall improvement in symptomatology score was observed. Ovarian volume increased significantly from baseline mean volume of 8.18±0.51cm³ to 19.3±0.84cm³ and no significant change in endometrial thickness was observed at the end of 3 month. Sweating, hot flushes, nausea and vomiting were the main adverse effects observed and were self limiting.Conclusions: Letrozole, the aromatase inhibitor resulted in significant volume reduction of the uterus-leiomyoma structure and was effective in controlling the more frequent symptoms of this disorder with fewer side effects.
Evaluation of intersystem agreement between standard pelvic organ prolapse quantification system and simplified pelvic organ prolapse scoring system
Authors: Singh Archana G. , Choudhary Varsha Rani , Ghanghoria Vineeta , Patel Kirti
Published: April 2017

Background: Pelvic organ prolapse (POP) is one of the most common gynaecological problem encountered worldwide. The POPQ has become the most commonly used prolapse staging system since its introduction (1996). In spite of having merits to it, POP-Q has not acquired a widespread acceptance. International Urogynaecological Association (IUGA) Standardization of Terminology Committee has devised a simplified version S-POP classification system based on the ordinal stages of the POPQ. The objectives of present study are to determine the intersystem agreement between the standard POPQ and S-POP classification system of pelvic organ prolapse and to propose a user-friendly classification system.Methods: This prospective observational blinded study was conducted in the department of Obstetrics and Gynaecology, NSCB Medical College and Hospital, Jabalpur (M.P.) from March 2015-August 2016. 125 women underwent two separate pelvic examinations POPQ and S-POP, by two groups of gynaecologists at each site. Results were compared and analysed using appropriate statistics.Results: Out of 125 women 54 (43.2%) were in age group 41-50 years. 79 (63.2%) were post-menopausal. 102 (81.4%) were more than third parity. 107 (85.6%) had home delivery. 119 (95.2%) had symptom of something coming out of vagina. The weighted Kappa statistics for the intersystem agreement of S-POP system with POPQ system for overall stage was 0.82, 0.61 for both anterior and posterior vaginal wall, 0.9 for cervix and 0.87 for posterior fornix/cuff.Conclusions: There is significant agreement between the POPQ and S-POP classification systems of POP.
Current placenta previa management and outcome in a rural tertiary care centre
Authors: Sood Reena , Sharma Swati , Nagpal Madhu , Arora Madhurima
Published: April 2017

Background: The reported incidence for placenta previa averages 0.3% or 1 case in 300 to 400 deliveries. Multiparity, advanced maternal age, cigarette smoking, previous caesarean delivery, history of abortions or uterine surgical procedures are some of the risk factors contributing to the development of placenta previa. Massive obstetrical haemorrhage in placenta previa is associated with severe maternal morbidity and mortality. A significant number of mothers can be saved if right approach of management is followed in placenta previa.Methods: The present case study is a retrospective analysis carried out in a tertiary care centre to study the risk factors and maternal and perinatal outcome in cases of placenta previa. The study included antenatal patients diagnosed as placenta previa on sonography at or >26 weeks of pregnancy. Data was compiled and statistically analysed.Results: Incidence of Placenta Previa in our study was 0.54%. 73.2% patients had history of previous cesarean sections. 53.6% patients were referred from outside. 98.2% patients delivered by caesarean section. Obstetric hysterectomy was required in 3.5% of total cases. 10.7% cases required the ICU admission after delivery. There was no maternal mortality in the study group. The mean gestational age at delivery was 35±2.4weeks. The mean APGAR at 5 min was 9±2.2.Conclusions: Increasing rates of caesarean sections in present era indicate that incidence of Placenta Previa is expected to rise. Good antenatal care, availability of emergency obstetric services, infrastructure, blood bank facility, HDU and ICU care and NICU services can improve maternal and neonatal outcome.
A successful pregnancy outcome in a testicular cancer survivor: case report
Authors: Devi Renuka , Jagadeesan Nithya , Raghavan Saritha Kamala
Published: April 2017

Testicular cancer is the most common cancer in young men. We report a successful pregnancy that was achieved by intracytoplasmic sperm injection (ICSI) using cryopreserved semen from a man with testicular cancer. He was treated for left testicular mixed germ cell tumor with left radical orchiectomy followed by chemotherapy. Three years post chemotherapy, the couple had two successive failures of intrauterine insemination (IUI) with cryopreserved semen. The couple then underwent Assisted reproduction with ICSI. Ten oocytes were retrieved following stimulation of which six oocytes fertilized and progressed. She had transfer of two healthy embryos and the remaining four embryos cryopreserved. Singleton pregnancy was achieved and she delivered a healthy girl baby at 38 weeks of gestation. Assisted reproduction with ICSI is a boon to the male patients with cancer and offers them a chance of fathering their own biological offspring.
Comparison of NALC-NAOH processing method with C18-carboxy propyl betaine method for the detection of mycobacterium in sputum
Authors: Kumar G. Amar , Chandrasekaran S.
Published: April 2017

Background: Tuberculosis is an infectious disease which remains to be a major public health risk worldwide even after the availability of many highly sensitive diagnostic tools. Early case detection plays an important role in control of the disease which relies solely on the detection of acid-fast bacilli in clinical samples which is low sensitive. Prior decontamination of sputum sample may improve the detection of mycobacterium.Methods: A prospective study was conducted with a total of (N=464) clinically suspected TB patient sputum samples which were collected and processed directly for AFB. From which AFB +ve samples were excluded. The direct AFB-ve (N=279) samples were processed using concentration (NALC, CB-18) and culture (LJ medium). After concentration, smears were examined under oil immersion for acid fast bacilli by ZN staining.Results: Out of 464 sputum samples, 185 direct ZN stain +ve were excluded. Among the ZN-ve (N=279) samples, N= 48 (17.2%) were positive using NALC-NaOH method. The positivity has improved to N=69 (25%) using CB-18 and N=79 (28.3%) using culture (LJ medium).Conclusions: CB-18 is sensitive than NALC-NaOH method and its sensitivity is almost comparable to the gold standard culture using LJ medium. Therefore we conclude that the identification of AFB using CB-18 concentration method can be used in resource limited health care setups which might help us to diagnose the TB at the earliest.
RELIGIÃO E POLÍTICA: APROXIMAÇÕES E PERMEABILIZAÇÃO A PARTIR DO OLHAR DE JOVENS UNIVERSITÁRIOS
Authors: Mezzomo Frank Antonio , Pátaro Cristina Satiê de Oliveira , Rosa Daiana Nunes da
Published: April 2017

A pesquisa traça o perfil de jovens universitários de cursos de bacharelado no que se refere às ações e representações sobre religião e política. Para a realização da pesquisa, foi aplicado um questionário online junto a 157 estudantes ingressantes em 2014 dos cursos de bacharelado da Universidade Estadual do Paraná, Câmpus de Campo Mourão, abrangendo questões relativas ao perfil socioeconômico, religioso e político dos estudantes. Os resultados permitem apontar para permeabilização de fronteiras entre os campos religioso e político na compreensão dos jovens, com relevância para a influência exercida pela religião no modo como os jovens entendem e atuam social e politicamente.
BREVE PANORAMA DA CULTURA NOS JORNAIS MARANHENSES DO SÉCULO XIX
Authors: Reis Thays Assunção , Gadini Sérgio Luiz
Published: April 2017

O presente artigo busca identificar os primeiros indícios da cultura nos jornais maranhenses do século XIX. Para tanto, foi feito um levantamento, com base no catálogo de jornais da Biblioteca Benedito Leite, das publicações literárias ou artísticas do estado. Em seguida foram selecionados 10 títulos semanais para a identificação das variáveis culturais presentes nos impressos. Atrelado a isso, foram recortadas algumas referências históricas em busca de uma contextualização do Maranhão no século XIX. Por meio deste estudo, observou-se que a presença da cultura no jornalismo maranhense surge atrelada a literatura principalmente devido à atuação dos periódicos especializados neste segmento. Além disso, verifica-se nestes jornais uma noção de cultura concebida como um meio de formar o homem e direciona-lo a civilidade.
MOVIMENTO RADICAIS LIVRES: O VIRTUOSISMO HEROICO NA JUVENTUDE CONTEMPORÂNEA
Authors: Araujo Cristiano Santos
Published: April 2017

Este artigo objetiva perceber a função sócio-cultural da religião na juventude do movimento Radicais Livres, da Igreja Videira de Goiânia (BERGER, 1985; BAUMAN, 2003). Analisaremos a proposta de sexualidade chamada de corte, o namoro radical sem contato íntimo, como um virtuosismo heroico para a regulamentação do prazer (FOUCAULT, 2012) dentro deste agrupamento social religioso (WEBER, 2002; BOURDIEU, 1998). O percurso metodológico para analisar esta ambiência comunitária juvenil encontrará em duas obras literárias oficiais do movimento, escritas pelo seu fundador, o pastor Naor Pedroza (2007, 2009), cujo teor doutrinário é amplamente divulgado entre os jovens. O primeiro livro chama-se Geração radical: jovens na contramão, e o segundo, Corte e namoro: o desafio de um relacionamento radical, ambos os livros publicados pelo canal oficial da Igreja Videira, a editora Vinha. Perceberemos que há uma grande tensão entre a ética da esfera profana de uma sociedade erotizada e a santidade da respectiva fraternidade religiosa, que é vivenciada nas dimensões existenciais do caos e da ordem, o caos é visto nos usos da sexualidade de forma livre, e a ordem, nos processos de doutrinação e regulamentação do prazer implementado pela corte do movimento Radicais Livres.

Palavras-chave: Radicais Livres - Jovens - Virtuosidade - Foucault
Структурные изменения в пищевой промышленности Приморского края
Authors: Шмидт Юрий Давыдович , Гу Эркан
Published: April 2017

Пищевая промышленность является социально значимой составляющей продовольственного комплекса региона и оказывает значительное влияние на качество и уровень жизни населения территории. В статье отмечается, что существующий методический аппарат и экономико-математический инструментарий не позволяют в полной мере оценить качество и эффективность структурных сдвигов в пищевой промышленности региона. Предложена авторская методика количественной оценки величины и направления структурных сдвигов в пищевой промышленности, в которой предложены показатели качества структурных сдвигов и интегральный показатель в виде взвешенной суммы структурных сдвигов по составляющим отраслевой структуры пищевой промышленности с учетом их значимости. Качество структурных сдвигов оценивается по степени их соответствия рациональности структурных изменений в пищевой промышленности региона. Апробация методики на примере пищевой промышленности Приморского края позволила сделать содержательные выводы о величине и качестве структурных сдвигов в пищевой промышленности региона.
Корпоративная социальная ответственность в эпоху «сознательного капитализма»
Authors: Окорочкова Анастасия Александровна Анастасия Александровна
Published: April 2017

В настоящее время в деловом мире корпоративную социальную ответственность (далее – КСО) сводят к разного рода практикам, которые могут быть косвенно или частично связаны с устойчивым развитием бизнеса: к благотворительности, социальному инвестированию, маркетингу, связям с общественностью, управлению персоналом, взаимодействию с представителями органов государственной власти, а также к концепции общих ценностей. Даже если компания выполняет требования законодательства и соблюдает нормы деловой этики, своевременно платит налоги и выпускает годовой отчет по корпоративной социальной ответственности, это не обязательно свидетельствует о том, что компания является социально ответственной. В данной статье автор внимательным образом рассматривает разного рода практики в области КСО и посредством принципа отрицания выводит ее сущностные характеристики; описывает существующую систему взаимоотношений государства и экономики, которая развивается за счет роста «сознательного» спроса и предложения на рынке свободной конкуренции и утверждает, что КСО становится одним из самых важных и системообразующих институтов эпохи «сознательного капитализма».
Анализ текущего положения гражданского общества и его влияния на экономику России.
Authors: Горошков Иван Александрович
Published: April 2017

В настоящей статье рассматривается состояние, а также возможности для развития гражданского общества в России. Проведен анализ влияния гражданского общества на экономику нашей страны. Показано, что неразвитость гражданского общества отрицательно сказывается на экономике и качестве государственного управления. На этой основе автор делает вывод о необходимости развития институтов гражданского общества, в том числе через внесение изменений в нормативные правовые акты.
A radikalizmus szociális reprezentációja fiatalok körében
Authors: Murányi István
Published: April 2017

In the study, using data from an international research (Myplace), relying on the theory ofsocial representations, we examined the understanding of radicalism of young people aged 15to 26 and living in two towns in Hungary (Ózd and Sopron) which differ significantly regardingtheir political socialization. In accordance with an empirical method based on the theory,we analyzed the relationship between young people’s attitudes towards nationalism and thedemocratic principles and the representation of radicalism, following the structural and contentcharacterization of the representation of radicalism through the quantification of associationalresponses received in the questionnaire survey conducted in 2012.
Gyermekvédelem a változás-elmélet tükrében
Authors: Rácz Andrea
Published: April 2017

It is essential that the child’s individual needs determine the required services and how these can give adequate responses to children’s problems. In Hungary, the child protection system is driven by less established professional principles, service planning and provision are of an ad hoc nature, child protection services lack any conscious design. The present study is based upon main qualitative results obtained from the research subject of “Is the State a Good Parent?”. Our goal is to reveal how the child’s needs are met in the system of the Hungarian child protection services (institutional and foster care), in what way the system can serve best the interests of the child, what systemic flaws can be identified according to child protection experts opinion.
A hadifogolytábor gazdasága
Authors: Baluja Petra
Published: April 2017

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„Sarjainak sorsát-hírét vállára felöltvén”
Authors: Takács Izolda
Published: April 2017

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Zárt intézeti neveltek családdal kapcsolatos nézetei
Authors: Hegedűs Judit , Fekete Márta , Sipos Szandra
Published: April 2017

When researching the reasons for criminal behaviour, literature almost unequivocally emphasises the responsibility and role of the family, where as the number of studies analysing the functioning of families of inmates in closed institutions (reform schools, special children’s homes) is relatively low. The present pilot research (with the purpose of preparing a wider one) tries to fill this gap. Using semi-structured interviews, we attempted to explore the inmates’ family background, what methods were used during their upbringing, what they thought about the family and its role and importance in one’s life. Harassment had occurred in juvenile delinquents’ families in various forms: it had physical and emotional manifestations, and therefore its impact on the affected person’s personality is extremely complex. These young people did not/do not have a safe background, and thus they were more easily influenced to choose the wrong way; they did not have a real childhood, never had the experience of common games or hiking, and never felt an atmosphere of trust, love and security. It was apparent that in these young people’s families very little attention was paid to each family member’s personal sensitivity or opinion, and emotional ties were either missing or were strongly distorted. In such a family environment, the young people were unable to solve the crises of adolescence which are parts of normal development, the family did not ensure support in coping with the tension, and they were left alone with solving their problems. Consequently, it is not surprising that they had great difficulties in telling what the family meant to them and what ideas they had about their future family.
Választási rendszerek Kelet-Közép-Európában
Authors: Fábián György
Published: April 2017

The democratic transition in Eastern and Central Europe provides a good opportunity toexamine how to apply the findings of the science of elections in a new dimension. This studybased on 167 elections in 23 countries shows the formation, evolution and political consequencesof the new electoral systems. The hypothesis of the paper is that the elections and electoralsystems in this region not always correspond to the conventional wisdom. Our analysis dividesinto five parts the region (Central Europe, Western and Eastern Balkans, Baltic States and theother former republics of Soviet Union). This division helps to get an sophisticatad picture aboutthe emergence and changes of the new electoral systems. By showing country by country we candemonstrate the similarities and differences between and within subgroups as well. Finallyusing three well-known indices (least square index, effective electoral and parliamentarynumber of parties) the study summarizes – country by country and subgroups by subgroups bytype – the political consequences for the proportionality and party structure. The analysis of the167 elections demonstrates that Eastern and Central Europe does not show uniformity regardingthe political consequences of the electoral systems. Their influence is more moderate than in theestablished democracies and they are also much more volatile. Their changes have shown ratherdiverging than converging trend in the last quarter century. The conventional findings aredifficult to apply for this region, they are only partially valid, especially the formation of partystructure differ from the previous experiences. In sum the Eastern and Central European electionsdo not invalidate the conventional statements of the elctoral studies but they offen do not showcorresponding image. So they significantly contribute to the further development and refinementof the previous findings.
TAKHRIJ AL-HADITS TENTANG PERALATAN MAKAN NABI SAW
Authors: Hudaya Hairul
Published: April 2017

For the Muslims, the position of the Prophet Muhammad is not only transmitting the revelations, but also explaining and realizing them in all aspects of his life. Therefore, the description of how and what he ate is included as parts of the hadith. Nevertheless, the practice of hadith can not be separated from the assessment of the quality of these hadith. The results showed that the hadith associated with the Prophets tableware and Food is authentic both from its sanad and matan. The Hadith can be understood as a form of the humble life style of the prophet. This attitude fits with what is said in the Qur'an and the Hadiths
UPAYA GURU AL-QUR’AN DALAM MENGATASI KESULITAN BELAJAR MEMBACA AL-QUR’AN DI SDIT UKHUWAH BANJARMASIN
Authors: Mubarak Hafiz
Published: April 2017

This research had goal to gain knowledge about any difficulties experienced by student since learning to read theQuran and what methods used by the Quran teachers to overcome learning difficulties. This research usedqualitative approach. The amount of data source was not determined, but it was based on snowball sampling.Although, the amount of research subject was not determined, the process of moving the research data was onsubjects at SDIT “Ukhuwah” Banjarmasin. The results showed that the learning difficulties experienced bystudents in the third grade to learn to read the Qur’an were: the students were difficult to concentrate or to focuse;a very active student verbally; slow student learning; student who had a low voice; student shard looked; studentsactively engaged; passive student; students had not been studied together with the child standard abilities; thenumber of children who were too much in the group.
PEMAHAMAN HADIS-HADIS MISOGINIS MENURUT ULAMA HADIS DAN FEMINIS MUSLIM INDONESIA
Authors: Usamah Usamah
Published: April 2017

This article analyses some prophetic sayings (hadith) considered misogenic, by comparing commentaries of the medieval ulama and the contemporary Muslim feminists in Indonesia. The first hadith is about woman leadership. Based on this hadith, many traditional ulama do not allow woman to be the leader. However, some medieval ulama such as Jalaluddin al-Sayuthi, al-Tabari and Abu Hanifah, do allow woman to become a leader. In line with this view, Indonesian Muslim feminists argue that woman deserves to be a leader like man, and the hadith should be understood in its specific context, namely that it talks about Persian Imperium which was led by a woman, so that it cannot be generalized. Morever, the hadith is ahad, reported by one line of transmitters. The second hadith is about God’s condemnation on a wife who refuses her husband for sexual intercourse. The traditional medieval ulama and Indonesian Muslim feminists agree that this hadith is also applied to man, that is, if he refuses his wife. Finally, the hadith stating that woman is less intelligent, according to the traditional ulama, means not to humiliate her, but to be aware of her temptation.
Privacidade, Pós-modernidade jurídica e Governança digital: o exemplo do Marco Civil da Internet na direção de um novo direito
Authors: Pilati José Isaac , Vieira Cancelier de Olivo Mikhail
Published: April 2017

Resumo: 2014 foi um ano importante para o Brasil quando se analisa a produção normativa relacionada à governança da internet. Isso porque, além da sanção da Lei n. 12.965 (o Marco Civil da Internet), realizou-se o Encontro Multissetorial Global Sobre o Futuro da Governança da Internet (NETmundial), evento que reuniu em São Paulo representantes de todas as esferas de usuários da rede, além de enviados de diversos países e organizações internacionais. Tanto no decorrer da elaboração do projeto de lei que gerou o atual Marco Civil da Internet quanto no desenvolvimento do referido evento, procedimentos participativos demonstraram-se fundamentais ao processo de construção do Direito referente ao tema, e um assunto ganhou enorme relevância, o direito fundamental à privacidade. Fazendo uso dos exemplos citados como base ilustrativa, neste artigo buscou-se relacioná-los à teoria da pós-modernidade jurídica, chamando a atenção para uma nova perspectiva do direito à privacidade: a coletiva.Palavras-chave: Direito à privacidade. Pós-modernidade jurídica. Internet. Processo participativo.
Gênero e práticas de saúde: singularidades do autocuidado entre adolescentes
Authors: Santos Rodrigo Ribeiro dos , Garrocho Junior Norberto Marques , Martins Alberto Mesaque , Modena Celina Maria
Published: April 2017

Este é um estudo descritivo e exploratório que buscou compreender as implicações de gênero nas práticas de saúde e autocuidado de adolescentes e identificar a opinião deles acerca das ações oferecidas nas Unidades Básicas de Saúde (UBS). Participaram 347 adolescentes matriculados nos anos finais do Ensino Fundamental e Ensino Médio de duas escolas públicas de Belo Horizonte, os quais responderam a um questionário semiestruturado e autoadministrado. Os resultados revelam influências do processo de socialização e construção social das identidades masculinas e femininas nas práticas de autocuidado entre o grupo de adolescentes. Os meninos relataram maior frequência de atividades físicas e uma menor utilização dos serviços e ações voltados para a promoção da saúde e prevenção de agravos, utilizando, com maior frequência, os serviços de urgência e emergência. As deficiências estruturais e organizacionais das UBS e o acolhimento das equipes de saúde foram apontados como pontos negativos que dificultam a vinculação do público adolescente.
Qualidade de Vida e Transtornos Psíquicos Menores em Seminaristas Católicos
Authors: Andrade Denisval Pereira , Souza José Carlos , Figueiró Mirna Torres , Andrade Karina Oliveira , Andrade Vinicius Oliveira
Published: April 2017

A religiosidade e a espiritualidade sempre foram consideradas importantes elementos de suporte para as pessoas que sofrem e/ou estão doentes. Objetivo: Avaliar a Qualidade de Vida (QV) geral e a prevalência de transtornos psíquicos menores nos seminaristas católicos. Método: Um estudo de corte transversal, descritivo e comparativo. Foram entrevistados 68 seminaristas católicos por meio dos questionários sociodemográfico, World Health Organization Quality of Life (WHOQOL-100) e Self Report Questionnaire (SRQ-20). Resultados: A avaliação da QV mostrou-se alta em todos os domínios investigados. Com relação ao cruzamento entre as dimensões do WHOQOL-100 e a presença/ausência de sofrimento mental, em todos os domínios do instrumento de qualidade de vida, e SRQ-20, houve diferença significativa, demonstrando que os candidatos que possuíam sofrimento mental estavam piores em relação aos que não possuíam em todos os domínios do WHOQOL-100. Conclusão: A QV dos seminaristas foi boa e a prevalência de transtornos psíquicos menores não foi significante.
(Re) pensando a função social da escola na atualidade
Authors: Oliveira Marli Dos Santos de , Amorim dos Reis Maria das Graças Fernandes de
Published: April 2017

O presente texto tem por objetivo analisar qual(is) a(s) função(es) social(is) atribuída(s) à escola sob a perspectiva de professores e alunos do Ensino Fundamental de escolas públicas de Naviraí, Mato Grosso do Sul, MS. Realizou-se uma revisão da literatura sobre o tema, subsidiando-se em autores como Saviani (2003), Rodrigues (1988), Freire (1996) Bourdieu e Passeron (1992), entre outros, além da realização de entrevistas com professores e alunos. Os participantes entrevistados concebem a função da escola como a de ensinar os conhecimentos historicamente produzidos, porém, nota-se dificuldades em definir o que de fato é essencial e o que é secundário no trabalho educativo escolar.
Synthesis and Anti-Tumor Activity of Oleanolic Acid Derivatives
Authors: ZhenYu Kuai , Li Lei , Zhan Shengwen , Li Chunlin , Zhao Yuwei , Chen Hongrong , Meng Yanqiu
Published: April 2017

Using the techniques of computer-aided drug design, the docking of Survivin and known active small molecules was simulated and then the key amino acid residue fragment of the target protein was analyzed. It led to the discovery of active groups capable of binding to the critical sites. Through the use of the natural product, Oleanolic Acid, as a lead compound, the introduction of the active groups onto the A-ring, and the modification of the carboxyl group at the C-28 position using esterification or amidation, twenty new Oleanolic acid derivatives had been designed and synthesized.A549 and SGC-7901 cells were used to screen the antitumor activity in vitro through the standard MTT method. The compounds, II3, III5 and Ⅳ4, exhibited more potent cytotoxicity than positive drugs.
Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields
Authors: Montagnier L. , Aïssa J. , Capolupo A. , Craddock T. J. A. , Kurian P. , Lavallee C. , Polcari A. , Romano P. , Tedeschi A. , Vitiello G.
Published: April 2017

We discuss the role of water bridging the DNA-enzyme interaction by resorting to recent 1 results showing that London dispersion forces between delocalized electrons of base pairs of DNA 2 are responsible for the formation of dipole modes that can be recognized by Taq polymerase. 3 We describe the dynamical origin of the high efficiency and precise targeting of Taq activity in 4 PCR. The spatiotemporal distribution of interaction couplings, frequencies, amplitudes, and phase 5 modulations comprise a pattern of fields instantiating the electromagnetic image of DNA in its 6 water environment, which is what the polymerase enzyme actually recognizes at long range. The 7 experimental realization of PCR amplification, achieved through replacement of the DNA template 8 by the treatment of pure water with electromagnetic signals recorded from viral and bacterial DNA 9 solutions, is found consistent with the gauge theory paradigm of quantum fields.
Ranolazine alone or as a complement to the amiodarone for both prevention and cardioversion of atrial fibrillation: A meta-analysis of the literature
Authors: De Vecchis Renato , Ariano Carmelina
Published: April 2017

Introduction Recent evidence from relatively small randomized controlled trials would seem to support a useful role of ranolazine for the prevention and treatment of atrial fibrillation (AF). The present study is aimed at providing information about the possible beneficial anti-arrhythmic properties of   ranolazine. In particular, the meta-analysis carried out in this study focuses on the application of ranolazine to prophylaxis and treatment of atrial fibrillation.Methods Both  randomized controlled trials (RCTs) and  non randomized observational  studies concerning the effects of ranolazine on AF were included in the meta-analysis. In each of the considered studies, a comparison was made between a group of patients taking ranolazine and a second group treated instead with another antiarrhythmic therapy , or assigned to placebo. Efficacy outcomes were the risk of new- onset AF, the probability of conversion to sinus rhythm of patients with recent occurrence(≤ 48 h)of AF and the time to conversion to sinus rhythm. Safety endpoints were death, adverse events, QTc  prolongation and hypotension.Results Ten studies ( 8 RCTs and 2 nonrandomized observational studies) were gathered on the whole.  Ranolazine was effective in preventing the occurrence of AF when compared to controls (RR= 0.60; 95% CI: 0.43–0.83; p = 0.002). Subgroup analysis showed a more  pronounced preventive effect  of ranolazine against AF in the postoperative setting of coronary artery bypass grafting(CABG) surgery (RR= 0.39; 95% CI: 0.18-0.83; p=0.02) when compared to non- postoperative AF (RR= 0.76; 95% CI: 0.63-0.92; p=0.04). Ranolazine enhanced the chances of successful cardioversion when added to intravenous amiodarone compared to amiodarone alone  (RR 1.18; 95% CI: 1.05–1.33; p = 0.004) and  significantly decreased the  time to cardioversion(SMD= −10.35 h; 95% CI: −18.13 hours to − 2.57 hours; p < 0.001). Overall risks of death, adverse events, and QTc prolongation were shown to be similar in the comparison between patients treated with ranolazine and controls. Conclusions Ranolazine given orally at appropriate doses showed the property to significantly quicken the conversion of AF to sinus rhythm when combined with the iv amiodarone, compared to iv amiodarone alone . Furthermore, in patients in sinus rhythm, ranolazine   proved to reduce the frequency of new onset AF as well as of its recurrences, especially in patients undergone CABG surgery, known to be at high risk of developing postoperative AF. In addition, ranolazine use seems to be safe and associated with relatively few adverse events.
PRANATA HUKUM BERBASIS KEARIFAN LOKAL DALAM TATA KEHIDUPAN BERBANGSA DAN BERNEGARA
Authors: Asrori S M. Hudi
Published: April 2017

Abstract
In the transition system of modern life with all the phenomena that arise, at present, there are patterns of local wisdom and the life that holds fast to the principle ofl ifeis based on national values and moral, as well as discipline and obedience to the rules applicable in the environment. It exists in the Java community, especially in the Palace of Yogyakarta Sultanate. The conceptof national and state basis for a civilizednation Indonesia based on the persistence of religion and practice their religion according to their beliefs. Constitutionally this concept set for thin the Grundnorm Pancasila and Undang Dasar1945. Institutions based on local wisdom (Java) as aservicein the life of the nation is to up hold the principle of national unity Bhineka Tunggal Ika, the work ethic Tan Hana Dharma Mangrowa, based on the principle, Manunggaling Kawulo Gusti, Golong Gilig implemented, with the credo of service Nyawiji, Greget, Sengguh and Ora Mingkuh, to realize Hamemayu Hayuning Bawono as a primary goal in the life of the nation is prosperous, fairly and prosperous
KEMANDIRIAN PENGADILAN TINDAK PIDANA KORUPSI DALAM SISTEM KETATANEGARAAN DI INDONESIA
Authors: Santoso M. Agus
Published: April 2017

Abstract

Purpose of this study is to find out the independence of the judiciary of corruption in the state system in Indonesia. The method used is a normative legal research methods (legal research), with the approach of the statute .Data sourced from legislation, library materials, and interviews. Qualitative data was analyzed in such a way and set out in writing a descriptive analysis. The results of this study illustrate that the independence of the corruption judiciary is determined from the independence of its institutions, the courts, and the judges. The intervention against corruption court decision is not aimed at her agency or the judicial process, but addressed to the judge overseeing the corruption case, in the form of feedback, criticism and even censure which was published in a newspaper that has led to contempt of court.

Key words: Independence of corruption court, and constitutional system.

Abstrak

Tujuan Penelitian ini ialah untuk mengetahui kemandirian pengadilan tindak pidana korupsi dalam sistem ketatanegaraan di  Indonesia.  Metode yang digunakan ialah metode penelitian hukum normatif (legal research), dengan pendekatan perundang-undangan (Statute approach) .. Data yang  bersumber dari perundang-undangan, bahan pustaka, dan hasil wawancara. Data kualitatif kemudian dianalisis sedemikian rupa dan dituangkan dalam bentuk tulisan secara diskriptif analisis. Hasil penelitian ini memberi gambaran bahwa bentuk kemandirian pengadilan tindak pidana korupsi ditentukan dari kemandirian lembaganya, proses peradilannya, dan hakimnya. Adanya intervensi terhadap putusan pengadilan tindak pidana korupsi bukan ditujukan terhadap lembaganya atau proses peradilannya, tetapi ditujukan kepada hakim yang menangani perkara korupsi, berupa tanggapan, kritik dan bahkan celaan yang dimuat dalam berita surat kabar yang sudah mengarah pada contempt of court.

Kata kunci: Kemandirian Pengadilan Tipikor, dan sistem ketatanegaraan.
STUDI EVALUATIF PERAN HAKIM AD HOC dALAM PENYELESAIAN PERSELISIHAN HUBUNGAN INdUSTRIAL dI PENGAdILAN HUBUNGAN INdUSTRIAL YOGYAKARTA
Authors: Wijayanta Tata Wijayanta , Hernawan Ari
Published: April 2017

Abstract

The research aim to evaluate the role of ad hoc judges in the settlement of industrial relation disputes, as well as to explore further what are the obstacles which may occur in the course of performing their duties. The research is a normative-empiric legal research. The data research comes from secondary data derived from literature studies and primary data from field researches. The data analyzed by qualitatively. The results of this research will show that ad hoc judges are appointed by the Supreme court and assigned to cases by the President of the court of Industrial Relations. Since its establishment, there has only been two appointments of ad hoc judges (one from the enterpreneur and the other from the labor union), and the court has tried and decided upon 104 cases (2006-2011). The most paramount obstacle turns out to be the lack of knowledge of the ad hoc judges in civil procedural laws while trying and deciding cases before them.

Keywords: court of Industrial Relations, Ad hoc Judge

Abstrak

Penelitian ini bertujuan untuk mengevaluasi peran hakim ad hoc dan untuk mengkaji hambatan-hambatan yang dialami hakim ad hoc dalam penyelesaian perselisihan hubungan industrial di Pengadilan Hubungan Industrial (PHI). Penelitian ini merupakan penelitian hukum empiris bersumber pada data sekunder dan data primer melalui penelitian kepustakaan dan penelitian lapangan Data dianalisis secara kualitatif. Hasil penelitian menunjukan bahwa hakim ad hoc diangkat oleh Mahkamah Agung dan ditunjuk dalam suatu perkara oleh Ketua PHI. Sejak didirikan PHI yogyakarta hanya terdapat dua hakim ad hoc yang masing-masing merupakan perwakilan dari pengusaha dan pekerja. Sebanyak 104 perkara diperiksa dan diputus oleh PHI yogyakarta antara 2006-2011. Hambatan utama yaitu kurangnya pengetahuan dan pemahaman hakim ad hoc tentang hukum acara perdata yang menghambat ketika para hakim ad hoc ini harus memeriksa dan memutus perkara.

Kata kunci:  Pengadilan hubungan industrial, Hakim ad hoc
PERGESERAN ASAS LEGALITAS FORMAL KE FORMAL DAN MATERIAL DALAM PEMBAHARUAN HUKUM PIDANA NASIONAL
Authors: Suartha I Dewa Made
Published: April 2017

Abstract

Legality principle is a fundamental basis in the criminal law. The principle of legality which is in accordance with Penal Code Article 1 (1), the law stateskhat there are not any actions that are made into a punisment without first all, have any basis of the rule which passed the actions completely. There are so many actions based on customery law as deviant behaviours and should be made into a criminal case (custom delict), but law enforcement can not follow it up because they are contrary to formal legality. And if there are customery law (custom delict) which will be made into criminal case by the court is in accordance with statutes No. 1/Drtl1951, the finding of a court seems unfair fro conventional norms. In Penal Code renewal, the legislative assembly have taken notes of conventional norms. In Penal Code Concept formal legality principle which has been practiced in Wet Boek van Straf Recht (WvS) system has been softened or widened into legality principle of material.

Key words: legality principle, criminal law renewal.

Abstrak

Asas legalitas merupakan asas yang sangat fundamental dalam hukum pidana. Asas legalitas yang tercantum dalam pasal 1 ayat (1) KUHP mutlak tunduk pada perinsip bahwa tidak ada suatu perbuaan yang dapat dipidana tanpa suatu dasar ketentuan undang-undang yang diadakan terlebih dahulu yang menetapkan dalam rumusan yang jelas dari perbuatan tersebut. Cukup banyak perbuatan yang menurut pandangan masyarakat sebagai perbuatan tercela dan patut dipidana (delik adat), akan tetapi penegak hukum tidak dapat menindak lanjutinya karena terbentur pada asas legalitas formal. Kalaupun ada di beberapa daerah delik adat diputus oleh pengadilan berdasarkan UU No. 1/Drt/1951, akan tetapi putusan pengadilan dirasakan tidak mencerminkan rasa keadilan masyarakat hukum adat. Dalam pembaharuan KUHP pembentuk undang-undang telah memperhatikan nilai-nilai hukum yang hidup dalam masyarakat. Dalam Konsep KUHP asas legalitas,(ormal yang selama ini dianut dalam sistem WvS (KUHP) telah diperlunak atau diperluas ke dalam asas legalitas materiel. Dengan perluasan asas legalitas maka pengadilan mempunyai landasan hukum untuk mengadili delik adat yang tidak ada bandingnya dalarrr KUHP.

Kata kunci : Asas legalitas, pembaharuan hukum pidana.
Alternatif atas Pemberlakuan Hukum Humaniter Internasional dalam Konflik Bersenjata Melawan Islamic State of Iraq and Syria
Authors: Kusumo Ayub Torry Satriyo , Tejomurti Kukuh
Published: April 2017

Abstract

Recently, there is a shift in armed conflict in the world from the conflicts among states or between state and belligerent into the conflict which happened across nations’ border, such as the Islamic State of Iraq and Syria (ISIS). The ISIS is a non-state actor, which consequently means that the conflicts cannot be properly categorized into international armed conflict. As the consequence, the international humanitarian law cannot be put into practice. The alternative solution is to apply the Martens Clause by paying an ultimate appreciation of fundamental principles of international humanitarian law for the sake of humanity and human rights.

Keywords : ISIS, Martens Clause, Fundamental Principle

 

Abstrak

Dewasa ini telah terjadi pergeseran subyek konflik bersenjata yang semula terjadi antar-negara atau antara negara dengan pemberontak menjadi konflik lintas-batas negara seperti Islamic State of Iraq and Syria (ISIS). Status ISIS dalam hukum internasional bukan sebagai negara melainkan sebagai aktor non negara (non-state actor). Perang melawan ISIS tidak termasuk ke dalam konflik bersenjata internasional karena tidak memenuhi kriteria berdasarkan Konvensi Jenewa Tahun 1949 dan Protokol Tambahan I Tahun 1977. Hal ini sangat mungkin memunculkan kesulitan pemberlakukan HHI. Sebagai alternatifnya, penerapan Martens Clause dapat dilakukan, yaitu dengan menghormati prinsip-prinsip fundamental yang menjadi dasar hukum humaniter internasional demi penghargaan terhadap kemanusiaan dan hak asasi manusia.

Kata kunci : ISIS, Martens Clause, Prinsip Fundamental
MODEL PERTANGGUNGJAWABAN HUKUM PELAKSANAAN CORPORATE SOSIAL RESPONSIBILITY (CSR) UNTUK MENINGKATKAN KESEJAHTERAAN MASYARAKAT
Authors: - Pujiyono , Wiwoho Jamal , - Triyanto
Published: April 2017

Abstract

Corporate Social Responsibility (CSR) is an obligation that imposed on a company under Article 74 of Law No. 40 Year 2007 regarding Limited Liability Company (UUPT). CSR implementation has some problems because of the lack of regulations (UUPT) that thera no sanctions for the companies that do not implement CSR. Currently, many companies that do not implement CSR maximally. So that the implementation of CSR is currently less of legal responsibility. Therefor,  it is necessary to formulate a model of CSR’s accountability in order to fill the legal vacuum that occurs at this time in order to improve the welfare of society. This research used research and development / R&D method. The location of research consits of PT Pertamina Hulu Energi (PHE) in Jakarta and some companies in Surakarta. The data used is derived from the primary data from informants, while secondary data in the form of journals, papers, reports, results of previous studies and other relevant publications. The Instrument collecting data using interviews, questionnaires, focus group discussions (FGD) and literature study. For the analysis used qualitative analysis techniques.

Keywords : CSR, Legal responsibility, the welfare of society.

Abstrak

Tanggung jawab sosial perusahaan atau Corporate Social Responsibility (CSR) merupakan kewajiban yang dibebankan kepada suatu perusahaan berdasarkan Pasal 74 Undang-Undang Nomor 40 Tahun 2007 tentang Perseroan Terbatas (UUPT). Pelaksanaan CSR masih menjadi persoalan karena belum adanya peraturan pelaksanaan dari UUPT tentang pengawasan dan sanksi bagi perusahaan yang tidak melaksanakan CSR. Saat ini banyak perusahaan hanya melakukan CSR secara suka-suka tanpa ada pedoman yang jelas. Sehingga pelaksanaan CSR saat ini kurang dapat dipertanggungjawabkan secara hukum. Untuk itu perlu dirumuskan model pertanggungjawaban pelaksanaan CSR guna mengisi kekosongan hukum yang terjadi saat ini guna meningkatkan kesejahteraan masyarakat. Penelitian ini menggunakan metode penelitian dan pengembangan (research and development / R&D). Lokasi penelitian meliputi PT Pertamina Hulu Energi (PHE) di Jakarta dan beberapa Perusahaan di Surakarta. Data yang dipergunakan yakni data primer berasal dari informan, sedangkan data sekunder berupa jurnal, makalah, laporan, hasil penelitian terdahulu dan publikasi lainnya yang relevan. Instrumen pengumpul data menggunakan wawancara, kuesioner, Focus Group Discussion (FGD) dan studi kepustakaan. Untuk analisis digunakan teknik analisis kualitatif.
Kata kunci: CSR, Pertanggungjawaban Hukum, Kesejahteraan Masyarakat
PRECAUTIONARY PRINCIPLE SEBAGAI LANDASAN DALAM MERUMUSKAN KEBIJAKAN PUBLIK
Authors: Latifah Emmy
Published: April 2017

Abstract

This study aims to explore on how to formulate and what should be considered in formulating the precautionary principle within public policy in order to generate appropriate and effective public policy. Precautionary principle is one of the important principles in International Law, particularly in International Environmental Law. This principle implies caution (prudence) in the face of new challenges, especially in the development of technology. Caution is not understood as an unwillingness to act or lack of courage to face new challenges, but on the contrary, the caution conduct is needed for the policy maker to make activity contain potential danger to the public butat the same time that danger is not understood  because

 Keywords: precautionary principle, public policy.

Abstrak

Penelitian ini bertujuan untuk mengeksplorasi bagaimana cara merumuskan dan apa saja yang harus dipertimbangkan dalam merumuskan precautionary principle dalam kebijakan publik agar menghasilkan kebijakan publik yang tepat dan efektif. Precautionary principle menjadi salah satu prinsip yang penting di dalam perkembangan Hukum Internasional, khususnya Hukum Lingkungan Internasional. Prinsip ini mengandung makna kehati-hatian dalam menghadapi tantangan baru salah satunya berupa perkembangan teknologi. Sikap kehati-hatian ini bukan dipahami sebagai ketidakmauan untuk bertindak atau kurangnya keberanian untuk menghadapi tantangan baru, namun sebaliknya, sikap kehati-hatian bagi para perumus kebijakan publik diperlukan untuk membuat keputusan yang tepat mengenai suatu produk atau kegiatan khusus di mana di dalamnya terdapat kecurigaan bahwa produk atau kegiatan tersebut mengandung potensi bahaya bagi masyarakat luas namun di waktu yang sama bahaya tersebut belum dimengerti karena belum adanya bukti-bukti ilmiah.

Kata kunci: precautionary principle, kebijakan publik.

 