bluuebunny/crossref_metadata_2025 huggingface dataset:
Formación docente en lengua extranjera en colegios del Distrito Lasallista de Bogotá : aproximación biográfico-narrativa
Authors: Bermúdez Jiménez Jenny , Cardona Serrano Aurora , Fandiño Parra Yamith José , Murcia Suárez Hno. Niky Alexander
Published: November 2021

En la Universidad de La Salle, el estudio de la formación docente exige comprender la manera en que los maestros viven los procesos formativos del sistema educativo y las dinámicas escolares de sus instituciones. Desde dicha perspectiva, este libro analiza cómo los maestros de lengua extranjera de cinco regiones del país han vivido veinte años de políticas, reformas y programas que buscaban circunscribir su pensar, su hacer y su ser. Los investigadores y los maestros participantes comparten una reflexión que se mueve entre la cr ítica de las apuestas programáticas del Ministerio de Educación Nacional en la vida de los maestros del Distrito Lasallista de Bogotá; la asunción del maestro como conocedor y analista crítico de su contexto de enseñanza-aprendizaje y la elaboración de referentes teórico-conceptuales que les proporcionen estrategias y lineamientos contextualizados. Tal reflexión trasciende los límites de las instituciones y los actores involucrados, de modo que es un referente de consulta y réplica para otras entidades que busquen transformar sus currículos y adaptar sus prácticas de enseñanza.
THE RELATIONSHIP OF FAMILY ROLES TO MEDICATION ADHERENCE IN SCHIZOPHRENIA PATIENTS
Authors: Rindayati Rindayati , Nasir Abdul , Rizal Chusnul
Published: November 2021

Introduction: Schizophrenia is a chronic mental illness with symptoms of hallucinations, delusions and inappropriate behavior. Patients require long-term treatment, but many do not adhere to treatment. The purpose of the study was to determine whether there was a relationship between family roles and adherence to medication for schizophrenic patients. Methods: The research design used correlation with a cross-sectional approach. The population of this study was 60 families with schizophrenia who visited the mental polyclinic of Ibnu Sina Hospital on 7-13 July 2019. The sampling technique used accidental sampling with a total sample of 52 respondents. Collecting data on family roles based on Friedman's theory and medication adherence using the Morisky Medication Adherence Scale. The research test used the Spearman rank test SPSS. Ethical Approval by Faculty of Nursing Universitas Airlangga number 1601-KEPK, July 17, 2019. Results: The results of this study showed that the role of the good family was 53.8% and the role of the less family was 46.2%. The medium level of adherence to taking medication was 42.3% and less level of adherence to taking medication was 32.7%. The results of the Spearman test are rho count 0.403 > rho table 0.271, which means that there is a significant relationship. Conclusion: The role of the family is related to medication adherence for schizophrenic patients.
PSYCHOEDUCATION REDUCES ANXIETY IN ELDERLY WITH HYPERTENSION IN NAMBAKOR VILLAGE SARONGGI DISTRICT SUMENEP
Authors: Suprayitno Emdat , Yasin Zakiyah , Karamah Istiqamatul , Puspitasari Dian Ika
Published: November 2021

Introduction: The problems in hypertension will cause emotional or mental disorders, one of which is anxiety. Feelings arise due to the fear and ignorance of an individual about hypertension experienced and the impact that will occur in the future. Psychoeducation is the provision of information about disease management and individual psychological aspects. This study aims to determine the effect of psychoeducation on the anxiety level of elderly patients with hypertension in Nambakor Village, Saronggi District.Methods: This research method is pre-experimental with the research design is one group pre test post test. The sampling technique used is Random Sampling and the number of samples is 30 respondents. Data collection using a questionnaire on the level of anxiety Depression Anxiety and Stress Scale.Result: The results showed that the mean of the anxiety score before the psychoeducation intervention was 24,43±7,60 and the mean of the anxiety score after the psychoeducation intervention was was 23,23 ± 7,83. The results of the paired t test of anxiety score was p = 0.002, means that there is significant difference in anxiety scores before and after psychoeducation.Conclusion: There is an influence of psychoeducation on the level of anxiety in the elderly with hypertension. The conclusion obtained is that psychoeducation can increase knowledge in patients with hypertension so that it is expected to be one form of intervention that can be applied.
THE RELATIONSHIP OF THE ROLE OF FAMILY IN PROVISION OF NUTRITION WITH NUTRITIONAL STATUS IN THE ELDERLY IN KLINTEREJO VILLAGE, SOOKO DISTRICT, MOJOKERTO REGENCY
Authors: Suidah Hartin , Murtiyani Ninik , Putra Wahyu Reza
Published: November 2021

Introduction Biological changes that occur in the elderly can affect nutritional status including reduced muscle mass, increased fat mass, decreased intestinal mobility, number of missing teeth, decreased sense of sight and reduced kidney capacity to excrete large amounts of water (Hutapea, 2015). As compensation for the decline in physiological functions, adequate nutrition must be provided to suit the activities of the elderly. Balanced nutritional intake is very necessary for healthy and sick elderly to maintain their quality of life and is needed in the healing process and prevent further complications from the disease (Siti, 2015). The family has an important role in maintaining the health status of the elderly through the fulfillment of balanced nutritional needs because the family is the closest party to the elderly.Methods:The research design used is a correlation research type because this study aims to determine the existence of a relationship between the role of the family and the nutritional status of the elderly with a Cross Sectional approach. The population is the elderly aged 60-90 years and over in Klinterejo Village, Sooko District, Mojokerto Regency as many as 52 samples with simple random sampling technique. Variable measurement instruments use questionnaires and KMS sheets. The statistical test uses Chi-Square with a value of = 0.05. Result: The results showed that almost half of the respondents (44.2%) had less family roles as many as 23 respondents and as many as 36 respondents (69.2%2 with poor nutritional status). Conclusion: Based on the results of the study, it is expected that the optimal role of the family in providing a balanced menu according to the needs of the elderly so that the nutritional status of the elderly is not in poor condition.
THE RELATIONSHIP BETWEEN THE LONG IN HEMODIALIZATION WITH STATUS OF EXCESS VOLUME OF LIQUID IN CHRONIC KIDNEY FAILURE PATIENTS
Authors: Harianto Susilo , Muhalla Hafna Ilmy , Cahyani Devi Purbandari Regita
Published: November 2021

Chronic kidney disease is a chronic disease that progresses damage to the kidneys which disrupts the body’s fluid and electrolyte balance which affects all body systems. PGK is currently it is one of the many diseases that have become a concern in the world including in Indonesia. One phenomenon that often occurs is an increase in fluid volume between two times of dialysis. The purpose of this study was to find out the long relationship between hemodialysis and excess fluid volume status in patients with chronic renal failure in the Hemodialysis room at Ibnu Sina Gresik Hospital. This was an analytical study with a correlative analytic design. Data were collected by using the contingency coefficient. The result of this study shows that older respondents underwent <1 year of hemodialysis with excess fluid status >2,5 BB post HD as much 81,2%, which is more dominant than patients who undergo > 1-year hemodialysis with excess fluid status >2,5 BB post HD as much 58% of the total resulting in p-value 0,103 where p>0,05 so it can be concluded that there is no long relationship to undergo hemodialysis with excess fluid volume status in patients with chronic kidney disease. It is expected that patients undergoing hemodialysis can be more obedient to the recommended diet so that it does not cause other complications and can improve the quality of life patients
Utilization of the library recreational function through the Gasibu Library Bandung
Authors: Anwar Rully Khairul , Agustine Merryam
Published: November 2021

Background of the study: One of the capabilities of the library is to provide pleasant conditions for relaxation that cannot be found at home. This research has the background to find out more about the recreational functions of public libraries through the Gasibu Bandung library which is located around the Gasibu field.

Purpose: The purpose of this study is divided into two parts, namely to determine the recreational function of the library as a means of channeling reading hobbies and to find out the Gasibu library as a tourism developer of Bandung city.

Method: The technique used in this research is a qualitative research technique with a case study method.

Findings: The results of this study indicate that the Gasibu library is an appropriate informative recreation facility to serve as a means of channeling people's reading hobbies and the Gasibu library can add to the tourist attraction of Bandung city because of the uniqueness of the information center in the middle of recreational facilities.

Conclusion: In fulfilling the recreational needs of its users, the Gasibu library is carried out by providing books that are suitable for its purpose. Novels and other literary forms, works of art, travel books, biographies, popular magazines, especially other recreational books. The Gasibu library building is also the main attraction because of its location in the middle of recreational facilities.
Cognitive modeling of informatization influence on socio-economic indicators of the region
Authors: Gorelova Galina , Magomedova Sabina , Feilamazova Svetlana
Published: November 2021

The article discusses topical issues of the influence of informatization on the development of the country’s regions in the conditions of the modern unstable world. The nature of the development of a region can be reflected and understood on the basis of qualitative and quantitative information about its socio-economic indicators, about their relationship and trends in their changes under the influence of internal and external factors. At the same time, information can most often be incomplete, difficult to access, untimely, contradictory, etc. Therefore, in this paper, it is proposed to use a cognitive approach and cognitive modeling of complex systems to overcome the problems of information deficiency by imitating cognitive modeling of the structure and behavior of a complex regional system. The simulation was carried out using the author’s CMCS (Cognitive Modeling Complex System) software system. The results of multi-stage cognitive modeling, consisting in the development of cognitive maps “Influence of ICT on the state of the region” and “Digitalization of the republic” (according to the socio-economic state of the Republic of Dagestan), analysis of structural properties and modeling scenarios for the development of situations on the model are presented. Scenarios make it possible to foresee the ways of possible development of the system under the influence of various factors, including the factor of informatization.
Travels in Scottland: Poems for Walter Scott @250
Authors:   University of Dundee
Published: November 2021

Welcome to the fifth collection by Wyvern Poets, in collaboration with the University of Dundee. 2021 marks the 250th anniversary of the birth of Sir Walter Scott (1771-1832), father of the historical novel and, effectively, of a new kind of mass ‘time travel’. Scott’s prolific output exported an image of his homeland with global appeal, if not always scrupulous authenticity. Stuart Kelly’s 2011 biography, Scott-land, is subtitled The Man Who Invented a Nation, perhaps without too much exaggeration. Scott’s antiquarian vision transformed a turbulent past into a pre-industrial landscape for the Romantic imagination, virtually overwhelming its place of origin or at least melding with it, as he rapidly became one the best-selling authors on earth. John Davidson’s ‘The Salvation of Nature’ (1891), fantasised a future Scotland bought out by an entertainment conglomerate. The World’s Pleasance Company, Ltd. demolishes anything built after 1700, ‘rewilding’ Scotland into a kind of neo-medieval theme park re-staging the past for tourists. Davidson’s story was both satirical exaggeration and backhanded tribute to Scott’s work for bringing history to life in a certain form. Hence this collection considers the many ways in which Scott’s evocative, but also problematic reimagining of his homeland remains relevant to our time and beyond.
Frailty Care Robot for Elderly and its Application for Physical and Psychological Support
Authors: Yamazaki Yoichi , Ishii Masayuki , Ito Takahiro , Hashimoto Takuya ,   Department of Home Electronics, Faculty of Creative Engineering, Kanagawa Institute of Technology 1030 Shomo-Ogino, Atsugi, Kanagawa 243-0292, Japan,   OKUBO GEAR Co., Ltd. 3030 Kamiechi, Atsugi, Kanagawa 243-0801, Japan,   CMK Products Corporation 1-1-11 Tanashioda, Chuo, Sagamihara, Kanagawa 252-0245, Japan,   Department of Mechanical Engineering, Tokyo University of Science 6-3-1 Niijuku, Katsushika, Tokyo 125-8585, Japan
Published: November 2021

To achieve continuous frail care in the daily lives of the elderly, we propose AHOBO, a frail care robot for the elderly at home. Two types of support systems by AHOBO were implemented to support the elderly in both physical health and psychological aspects. For physical health frailty care, we focused on blood pressure and developed a support system for blood pressure measurement with AHOBO. For psychological frailty care, we implemented reminiscent coloring with the AHOBO as a recreational activity with the robot. The usability of the system was evaluated based on the assumption of continuous use in daily life. For the support system in blood pressure measurement, we performed a qualitative evaluation using a questionnaire for 16 subjects, including elderly people under blood pressure measurement by the system. The results confirmed that the proposed robot does not affect the blood pressure readings and is acceptable in terms of ease of use based on subjective evaluation. For the reminiscent coloring interaction, subjective evaluation was conducted on two elderly people under the verbal fluency task, and it has been confirmed that the interaction can be used continuously in daily life. The widespread use of the proposed robot as an interface for AI that supports daily life will lead to a society in which AI robots support people from the cradle to the grave.
SELECTION AND JUSTIFICATION OF THE MATHEMATICAL 6 FACTORS EXPERIMENT PLAN IN THE STUDY OF ICE STARTING QUALITIES
Authors: Levchenko D.V.
Published: November 2021

The practical significance of the application of multivariate regression analysis in engineering practice as a necessary step towards improving and optimizing complex systems and processes is presented. The goal and investigation tasks have been actualized to optimize the start-up process of a high-speed subcompact diesel engine. Preparation of the plural factors experiment features of diesel start-up process based on regression analysis and the theory of mathematical design of experiment are presented. Qualitative optimizing parameters of the diesel engine cold start are determined: instantaneous acceleration of the crankshaft dn / dτ at the time of crankshaft cranking by an external energy source close to the time spent on starting the engine with optimal parameters of the starting system and starting energy consumed during the crankshaft cranking by an external energy source. Six main factors influence on certain parameters of the diesel engine start quality have been investigated. The regression equation for assessing the quality of the start-up process is substantiated. The form of regression equation is a full quadratic polynomial for the reproduction of the investigated functions, based on the previous study of some used in the study individual factors influence. The analysis of proposals for rational plan selection of a six-factor experiment to find the coefficients of the second-degree regression polynomial is carried out. The substantiation of the decision regarding the choice of the plan is given. Selection was based on the requirements of the investigation test bench and the conditions for study organizing. Main impact had the predecessors experience of similar investigation and the statistical criteria for different plans of experiment comparison used in mathematical theory of design of experiments. The points of the plan have been defined on a multidimensional cube due to the need to vary on three levels with a uniform step of all 6 factors that were identified as influential. Under the conditions of the available laboratory test bench, the current values of the factors of equivalent cold start temperature, crankshaft-cranking speed and maximum temperature of the glow plugs have a variance of the installation at different points of the plan, and the nature of the factors on energy consumption is unknown in advance. As a rational experimental design for organizing the current study, the Box-Wilson orthogonal central compositional plan was chosen, built by adding plan points on the axes of the factorial space to the full-factorial plan of the lowest order, while maintaining the requirement of orthogonality and symmetry of the plan.
Semi-automated land cover mapping using an ensemble of support vector machines with moderate resolution imagery integrated into a custom decision support tool
Authors: Lasko Kristofer , Sava Elena
Published: November 2021

Land cover type is a fundamental remote sensing-derived variable for terrain analysis and environmental mapping applications. The currently available products are produced only for a single season or a specific year. Some of these products have a coarse resolution and quickly become outdated, as land cover type can undergo significant change over a short time period. In order to enable on-demand generation of timely and accurate land cover type products, we developed a sensor-agnostic framework leveraging pre-trained machine learning models. We also generated land cover models for Sentinel-2 (20m) and Landsat 8 imagery (30m) using either a single date of imagery or two dates of imagery for mapping land cover type. The two-date model includes 11 land cover type classes, whereas the single-date model contains 6 classes. The models’ overall accuracies were 84% (Sentinel-2 single date), 82% (Sentinel-2 two date), and 86% (Landsat 8 two date) across the continental United States. The three different models were built into an ArcGIS Pro Python toolbox to enable a semi-automated workflow for end users to generate their own land cover type maps on demand. The toolboxes were built using parallel processing and image-splitting techniques to enable faster computation and for use on less-powerful machines.
ANALISIS PENGARUH KREATIF DAN INOVATIF DI DUNIA BISNIS KEWIRAUSAHAAN DALAM PERSPEKTIF EKONOMI ISLAM
Authors: Novita Mega Angel Virdianasari
Published: November 2021

In writing this article, it aims to determine the effect of the benefits of creative and innovative ideas in running an entrepreneurial business based in an Islamic economy. The method in writing this article is to use descriptive analysis literature study to analyze the influence of creative and innovative ideas on the entrepreneurial world. The data collection technique is to look for secondary data obtained from sources relevant to the topic of discussion. By taking the title, taking advantage of this idea will have a great opportunity to face existing challenges and have great potential in the face of increasingly fierce business competition today. Because if you don't take advantage of this idea, the business you are running will be unable to compete with similar businesses and consumers will feel uninterested in simple products so that the business we run will experience a decrease in sales levels. Therefore, the existence of this idea will have a considerable influence in the world of economy and business so that consumers do not feel bored to buy and use these products. However, consumers can feel satisfied because they can use products with many benefits that consumers can take advantage.

Dalam penulisan artikel ini bertujuan untuk mengetahui pengaruh manfaat ide kreatif dan inovatif dalam menjalankan bisnis wirausaha yang berbasis dalam ekonomi Islam. Metode dalam penulisan artikel ini ialah dengan menggunakan studi pustaka analisis deskriptif untuk menganalisis pengaruh ide kreatif dan inovatif terhadap dunia usaha wirausaha. Teknik pengumpulan data adalah dengan mencari data sekunder yang diperoleh dari sumber yang relevan dengan topik pembahasan. Dengan mengambil gelar tersebut, karena dengan memanfaatkan ide tersebut akan memiliki peluang yang besar untuk menghadapi tantangan yang ada dan memiliki potensi yang besar dalam menghadapi persaingan bisnis yang semakin ketat saat ini. Karena jika tidak memanfaatkan ide ini maka bisnis yang dijalankan akan kalah bersaing dengan bisnis sejenis dan konsumen akan merasa tidak tertarik pada produk sederhana sehingga bisnis yang kita jalankan akan mengalami penurunan tingkat penjualan. Oleh karena itu, keberadaan ide ini akan memberikan pengaruh yang cukup besar dalam dunia ekonomi dan bisnis agar konsumen tidak merasa bosan untuk membeli dan menggunakan produk tersebut. Namun konsumen dapat merasa puas karena dapat menggunakan produk dengan banyak manfaat yang dapat dimanfaatkan konsumen.
PENGARUH CAPITAL ADEQUACY RATIO, INFLASI, DAN GROSS DOMESTIC PRODUCT TERHADAP RETURN ON ASSETS (STUDI PADA BANK UMUM SYARIAH NON DEVISA DI INDONESIA PERIODE TAHUN 2018-2020)
Authors: Lutfi Indriwati  , Agung Eko Purwana
Published: November 2021

This research examines the influence of CAR, inflation and GDP on ROA of Non-Foreign Exchange Sharia Commercial Banks in Indonesia. In the research period there were cases in the financial statements where CAR increased but ROA decreased, in addition when inflation decreased ROA also decreased and at the time of GDP rise ROA again decreased. The novelty of this research is a method of regression of panel data that has never been used in CAR, inflation and GDP together. This research is quantitative with a sample number of 4 Non-Foreign Exchange Sharia Commercial Banks. The findings in this study are that CAR, inflation and GDP have no partial effect on ROA. However, CAR, inflation, and GDP simultaneously affect ROA. The next research is expected to take variables other than CAR, inflation, and GDP that theoretically affect roa of Non-Foreign Exchange Sharia Commercial Banks in order to obtain a better roa model of Non-Foreign Exchange Sharia Commercial Banks compared to this study.

Riset ini menguji pengaruh CAR, inflasi dan GDP terhadap ROA Bank Umum Syariah Non Devisa di Indonesia. Pada periode riset ditemui kasus pada laporan keuangan dimana CAR mengalami peningkatan namun ROA mengalami penurunan, selain itu ketika inflasi mengalami penurunan ROA turut mengalami penurunan serta pada saat GDP naik ROA kembali mengalami penurunan. Kebaruan dari riset ini berupa metode regresi data panel yang belum pernah digunakan pada CAR, inflasi dan GDP secara bersama. Riset ini berjenis kuantitatif dengan jumlah sampel 4 Bank Umum Syariah Non Devisa. Temuan pada riset ini adalah CAR, inflasi dan GDP secara parsial tidak berpengaruh pada ROA. Namun, CAR, inflasi, serta GDP secara simultan berpengaruh pada ROA. Riset berikutnya diharapkan dapat mengambil variabel lain selain CAR, inflasi, dan GDP yang secara teori berpengaruh pada ROA Bank Umum Syariah Non Devisa agar diperoleh model ROA Bank Umum Syariah Non Devisa yang lebih baik dibandingkan dengan penelitian ini.
A Novel Clinical Nomogram for Predicting Lymph Node Metastasis in Ovarian Cancer: A SEER Analysis and External Validation in a Tertiary Center
Authors: Zhang Guiping , Ren Wei
Published: November 2021

Introduction

The aim of the study is to investigate the risk factors for developing lymph node metastases (LNM) in cases diagnosed as a presumed early-stage ovarian carcinoma (OC).
Methodology

Information of patients who had been diagnosed as OC in 2018 was obtained from the SEER database. We enrolled 104 OC patients in General Hospital of Northern Theatre Command for external validation. A logistic regression was conducted to determine the independent predictors for LNM, which were used for establishing a nomogram. In order to evaluate the reliability of nomogram, we applied a receiver operating characteristic curve (ROC) analysis, calibration curves and plotted decision curves.
Results

We found that age(≥70, OR=0.544, p=0.022), histology type (Mucinous carcinoma, OR=0.390, p=0.001; Endometrioid carcinoma, OR=7.946, p=0.053; Others, OR=2.400, p=0.040), histology grade (Grade II, OR=2.423, p=0.028; Grade III, OR=1.982, p=0.152; Grade IV, OR=1.594, p=0.063) and preoperative serum CA125 level (positive, OR=2.236, p=0.001) were all significant predictors of LNM. The AUC of the model training cohort, internal validation cohort, and external validation cohort were 0.78, 0.79 and 0.76 respectively. The calibration curves showed that the predicted outcome fitted well to the observed outcome in the training cohort (p=0.825) internal validation cohort (p=0.503), and external validation cohort (p=0.108). The decision curves showed the nomogram had more benefits than the All or None scheme if the threshold probability is >50% and <100% in training cohort and internal validation cohort, >30% and <90% in the external validation cohort.
Conclusion

The multivariate logistic regression showed that age, histology type, histology grade and preoperative serum CA125 level were all significant predictors of LNM. The nomogram established using the above variables had great performance for clinical applying.
Evaluating Positive and Negative Effects of Seven Biogenic Metal-based Nanoparticles on Seed Germination and Seedling of Nano-primed Wheat and Flax Seeds
Authors: Bayat Maryam , Zargar Meisam
Published: November 2021

Seed germination is the first and the most susceptible stage in plant’s growing phases, so could be considered as an index to evaluate the effect of newly developed materials like nanoparticles (NPs), providing useful information for researchers. In our experiments, germination tests have been carried out in Petri plates, containing wet filter paper and nano-primed seeds. We had biosynthesized seven nanoparticles in our previous researches, including calcinated and non-calcinated zinc oxide, zinc, magnesium oxide, silver, copper and iron nanoparticles. The effect of these biogenic nanoparticles and their counterpart metallic salts including zinc acetate, magnesium sulphate, silver nitrate, copper sulphate and iron (III) chloride was studied on two popularly grown plants, wheat and flax, in laboratory condition to obtain preliminary information for future field experiments. Germination percentage, shoot length, root length, seedlings length, root-shoot ratio, seedling vigor index (SVI), shoot length stress tolerance index (SLSI) and root length stress tolerance index (RLSI) were calculated at 2nd and 7th days of the experiment. According to the results, the response of the plants to metal containing nanoparticles and metal salts mainly depend on type of the metal, plant species, concentration of the NP suspension or salt solution, condition of the exposure and the stage of growth.
Self-care Status and Influencing Factors of Patients with Chronic Heart Failure in Community from The Perspective of Health Ecology
Authors: Zhou Bingying , Xu Cuirong , Xu Xiaolu , Chen Yong , Tang Weihong
Published: November 2021

Objective To explore the current situation and influencing factors of self-care of patients with chronic heart failure in community. Methods Patients with chronic heart failure in four community health service centers of a third class hospital in Nanjing were selected as the research object. A questionnaire was formed based on health ecology to understand the current situation and influencing factors of self-care. The data were analyzed by one-way ANOVA and multiple linear regression.Results The self-care status of community patients with chronic heart failure was poor, and they were in the state of "low maintenance, low management and low confidence"; Social support level, anxiety, depression, number of complications, course of disease, education level and income were independent influencing factors of self-care ability of community patients with chronic heart failure (P < 0.05). Conclusion The self-care ability of community patients with chronic heart failure needs to be improved, which is affected by many factors. Personalized evaluation and active intervention should be carried out to improve the self-care ability and quality of life of patients with chronic heart failure.
Artificial Neural Network for analyzing the chaotic time series motion: The case of the Lebanese GDP
Authors: Verne Jean-François
Published: November 2021

In this paper, we propose to analyze the motion of the Lebanese GDP over the period 1950-2019. This macroeconomic aggregate reveals large fluctuations notably during the civil war period (1975-1990). By estimating the Lyapunov exponents with the Artificial Neural Network (ANN) procedure, we show that this series exhibits a strange attractor generated by a chaotic dynamic and we use the embedding procedure to shed in light the bizarre structure of such a series. Thus, the ANN method gives better results regarding prediction than other linear regression models and allows to fit with accuracy the chaotic motion followed by the Lebanese GDP in the phase space.
Molecular Diagnostic of Ochratoxin A with Specific Aptamers in Corn and Groundnut via Fabrication of A Microfluidic Device
Authors: Shahdeo Deepshikha , Khan Azmat Ali , Alanazi Amer M , Huh Yun Suk , Shukla Shruti , Gandhi Sonu
Published: November 2021

Ochratoxin A (OTA) is one of the predominant mycotoxins that contaminate a wide range of food commodities. In the present study, a 36-mer aptamer was used as a molecular recognition element coupled with gold nanoparticles (AuNPs) for colorimetric detection of OTA in a microfluidic paper-based analytical device (µPADs). The µPADs consisted of three zones: control, detection, and sample, interconnected by channels. The biophysical characterizations of aptamer conjugated AuNPs were done by UV-vis spectroscopy (UV-vis), dynamic Light Scattering (DLS), and transmission electron microscopy (TEM). The developed colorimetric assay for OTA showed a limit of detection of 242, 545, and 95.69 ng/mL in water, corn, and groundnut, respectively. The HPLC detection method achieved acceptable coefficient in standard curves (r2 = 0.9995), better detection range, and recovery rates in spiked corn and groundnut samples as 43.61 ± 2.18% to 87.10 ± 1.82% and 42.01 ± 1.31% to 86.03 ± 2.64% after multiple sample extractions and cleanup steps. However, the developed µPADs analytical device had the potent ability to rapidly detect OTA without any extraction pre-requirement, derivatization, and cleanup steps, thus illustrating its feasibility in the animal health sector, agricultural, and food industries.
Downregulation of Lipid Phosphate Phosphatase 3 correlates with Tumor-Infiltrating Immune Cells in Oral Cancer
Authors: Vishwakarma Supriya , Joshi Deepti , Pandey Ritu , Das Saikat , Mukhopadhyay Sramana , Singh Renu , Singhal Ritu , Kapoor Neelkamal , Kumar Ashok
Published: November 2021

Purpose

Sphingosine-1-phosphate (S1P), a potent oncogenic lipid. Intracellular levels of S1P are tightly regulated by eight S1P metabolizing enzymes. S1P is synthesized by phosphorylation of sphingosine which is catalyzed by two sphingosine kinases (SphK1 and SphK2). Five lipid phosphatases (two S1P phosphatases and three lipid phosphate phosphatases) reversibly convert S1P back to sphingosine. S1P is ultimately irreversibly degraded by S1P lyase. The role of sphingosine-1-phosphate (S1P) metabolizing enzymes in oral squamous cell carcinoma (OSCC) has not been fully studied.

Methods

In the current study, we have determined the protein expression of four S1P metabolizing enzymes, namely sphingosine Kinase (SphK) -1, SphK2, S1P phosphatase 1 (SGPP1), and lipid phosphate phosphatase 3 (LPP3) by immunohistochemistry (IHC) and western botting in tumor tissues of 46 OSCC patients and normal oral mucosa (N = 6). Further, we determined the associations of expression of S1P metabolizing enzymes with clinicopathological features of OSCC patients.

Results

SphK2 and LPP3 exhibit low IRS in OSCC tumors. Importantly, expression of SphK2 and LPP3 was downregulated in malignant cells compared to non-malignant mucosa. Further, LPP3 expression negatively correlated with TNM staging of patients (ρ = -0.307, p = 0.043). Importantly, TCGA analysis revealed that LPP3 expression was positively correlated with infiltration of B cells, neutrophils, macrophages, and dendritic cells in the HNSCC tumors.

Conclusion

In conclusion, our data show that expression of SphK2 and LPP3 is decreased in OSCC tumors compared to normal mucosa. Thus, LPP3 could represent a potential prognostic marker and therapeutic target for OSCC.
A Selected Population Study Reveals the Biochemical Mechanism of Intramuscular Fat Deposition in Chicken Meat
Authors: Cui Huanxian , Liu Lu , Liu Xiaojing , Wang Yongli , Luo Na , Tan Xiaodong , Zhu Yuting , Liu Ranran , Zhao Guiping , Wen Jie
Published: November 2021

Background

Increasing intramuscular fat (IMF) is an important strategy to improve meat quality, but the regulation mechanism of IMF deposition needs to be systematically clarified.
Results

A total of 520 chickens from a selected line with improved IMF content and a control line were used to investigate the biochemical mechanism of IMF deposition in chickens. The results showed that the increased IMF would improve the flavor and tenderness quality of chicken meat. IMF content was mainly determined both by measuring triglyceride (TG) and phospholipid (PLIP) in muscle tissue, but only TG content was found to be decisive for IMF deposition. Furthermore, the increase in major fatty acid (FA) components in IMF is mainly derived from TGs (including C16:0, C16:1, C18:1n9c, and C18:2n6c, etc.), and the inhibition of certain very-long-chain FAs would help to IMF/TG deposition.
Conclusions

Our study elucidated the underlying biochemical mechanism of IMF deposition in chicken: Prevalent accumulation of long-chain FAs and inhibitions of medium-chain FAs and very long chain-FA would synergistically result in the increase of TGs with the FA biosynthesis and cellular uptake ways. Our findings will guide the production of high-quality chicken meat.
Metabolomics Profiling of Brassinolide and Abscisic Acid In Response to High Temperature Stress
Authors: Lv Jinhua , Dong Tianyu , Zhang Yanping , Ku Yu , Zheng Ting , Jia Haifeng , Fang Jinggui
Published: November 2021

To determine the effect of abscisic acid (ABA), brassinolide (BR) and ABA+BR on grape quality under high temperature stress (HTS), various metabolites were analyzed. Compared with the control (CK), DL-tryptophan, D-raffinose, geniposidic acid, dodecanedioic acid and polyphenols were found to be higher after ABA treatment. After BR treatment, amino acids and poricoic acid B were higher than in CK. And carbohydrates and amino acids were upregulated after ABA+BR treatment. BR and ABA+BR treatment also induced higher endogenous ABA and epibrassinolide (EBR) contents. In addition, treated grape had higher soluble solid concentrations (SSC) and soluble sugar content, and delayed the degradation of middle lamella and microfibrils. Antioxidant and heat shock related genes were examined, which significantly increased in treated grape. The finding of this study suggested that ABA, BR and ABA+BR are very useful for alleviating high temperature damage by increasing the accumulation of osmotic adjustment substances, and endogenous hormones content.
Investigating EFL Learners’ Perceptions Towards the Difficulties in Oral Presentation at Kandahar University
Authors: Tareen Hashmatullah , Faizi Farishta
Published: November 2021

This research paper examines the difficulties of oral presentation, strategies coping with difficulties used in oral presentations and the perceived role of lecturer in improving EFL learners’ oral presentation skills. The study used quantitative approach in which a survey questionnaire comprising 34 items based on four likert scales was distributed to EFL learners in a public university. The data was collected from 150 learners from two English Departments through random sampling which 109 were male and 41 were female learners. The data was analyzed and interpreted in terms of mean and standard deviation through SPSS software (22) version. The results of the study revealed that learners had a problem with oral fluency, accuracy and pronunciation during oral presentation, feel frightened when a lot of people are watching them, afraid of being assessed by their classmates in front of the class, having low self-confidence. The results also revealed some strategies coping with difficulties used in oral presentation such as, learners have to prepare themselves properly before an oral presentation, they have to build self-confidence for presentation to present very well and they have to concentrate more on phonetics and phonology of language. Furthermore, considering a crucial role of lecturer in improving oral presentation skills, the following factors such as lecturer has to design a specific course in teaching oral presentation skills for EFL learners, lecturer has to show learners videos of good speakers for enhancing their presentation skill and lecturer has to give learners freedom to choose their own topic that lowers their anxiety were discovered for more consideration.
How Does HbA1c Predict Mortality and Readmission in Patients with Heart Failure? A Protocol for Systematic Review and Meta-analysis
Authors: Xu Junpeng , Zeng Ruixiang , Mai Xiaoyi , Pan Wenjun , Zhang Yuzhuo , Zhang Minzhou
Published: November 2021

BackgroundAccumulating evidence suggests that HbA1c levels, a common clinical indicator of chronic glucose metabolism over the preceding 2-3 months, are independent risk factor for cardiovascular disease, including heart failure. The aim of this protocol is to conduct a systematic review and meta-analysis to assess the possible predictive value of HbA1c on mortality and readmission in patients with heart failure.MethodsA systematic and comprehensive search will be performed using PubMed, Embase, Central and other databases before August 2021 to identify relevant trials. All-cause mortality is the pre-specified primary endpoint. Cardiovascular death and heart failure readmission are secondary interested endpoints. We will only include prospective and retrospective cohort trials and place no restrictions on the language, race, region and publication period. The Newcastle-Ottawa Scale will be used to assess the quality of each trial included. If there are sufficient trials, we will conduct meta-analysis with pooled relative risks and corresponding 95% confidence interval to evaluate the possible predictive value of HbA1c on mortality and readmission. Otherwise, we will undertake a narrative synthesis. Heterogeneity and publication bias will be assessed. If heterogeneity is significant among included trails, a sensitivity analysis or subgroup analysis will be used to explore the source of heterogeneity, such as diverse types of heart failure or patients with diabetes and non-diabetes. Also, we will conduct meta-regression to examine the time-effect and treatment-effect modifiers on all-cause mortality compared between different quantile of HbA1c levels. Finally, a restricted cubic spline model may be used to explore the dose-response relationship between HbA1c and adverse outcomes.DiscussionThis planned analysis is anticipated to identify the predictive value of HbA1c on mortality and readmission in patients with heart failure. Improved understanding of different HbA1c levels and their specific effect on diverse types of heart failure or patients with diabetes and non-diabetes is expected to be figured out. Also, a dose-response relationship or optimal range of HbA1c will be determined to instruct clinicians and patients.PROSPERO registration detailsCRD42021276067
WITHDRAWN: Effects of GABAA Receptors in Dorsal Hippocampus on Memory Retention of Cholestatic Rats
Authors: Chen Ruili , Zhang Dongdong , Tayyebi Sepideh , Li Nini
Published: November 2021

The molecular mechanisms that result in cognitive deficits following cholestasis are mainly unknown. As there are many GABAA receptors in the hippocampus CA1 region and the crucial role for GABA in modulating memory, we evaluated the effects of GABAA receptor agents in the CA1 of cholestatic rats on memory retention. The interaction between GABAergic and opioidergic systems in the CA1 on memory was also investigated. The effects of administration of GABAA receptor agonist and antagonist, muscimol (60, 120 and 240 ng/ side) and bicuculline (100, 200 and 400 ng/ side), into CA1 on memory retention were studies using passive avoidance learning (PAL) task in bile duct ligated (BDL) rats. Naloxone (250 ng/ side), the mu-opioid receptor antagonist, was also co-administered alone or with bicuculline (400 ng/ side) to indicate the interaction between opioidergic and GABAergic system. Cholestasis inhibited memory retrieval is shown by the decrease in the step-through latency (STLr). Administration of muscimol or bicuculline alone after training potentiated or attenuated respectively amnesia in BDL rats dose-dependently. Naloxone (250 ng /side) alone increased STLr in BDL-treated rats. Bicuculline (100 ng/side) alone antagonized the amnesic effect of muscimol (120 ng/side). Co-administration of bicuculline and naloxone or muscimol and naloxone caused a significant difference in STLr compared to only naloxone treated rats which show the interaction between two systems on memory retention in cholestssis. Bicuculline (100 ng/side) microinjection alone antagonized the amnesic effect of muscimol (120 ng/side). We indicated the contribution of intra-CA1 GABAA receptors on memory retention in cholestatic rats by the PAL test. Blockade of each GABAA or mu-opioid receptors alone could attenuate the amnesia in BDL rats. Furthermore, blockade of both GABAA or mu-opioid receptors reversed the memory deficit in BDL-treated rats, which shows the interaction between GABAergic and opioidergic systems on memory retention in this test.
Production Enhancement of Human Adipose-Derived Mesenchymal Stem Cells By Low-Intensity Ultrasound Stimulation
Authors: Min Soohong , Byeon Yungsun , Kim Min , Lee Youngjun , Lee Hongki , Paeng Dong-Guk
Published: November 2021

Background: Low-intensity ultrasound (LIUS) has been used to increase the proliferation rate of various stem cells including human adipose-derived mesenchymal stem cells (hAdMSCs). hAdMSCs is now commercially produced for various therapeutic applications. The purpose of this study was to show feasibility of enhancing the productivity of cell culture during 16-day cell culturing and increasing proliferation rate of hAdMSCs by LIUS stimulation with appropriate ultrasound parameters. Methods: Beam patterns of 5 and 10 MHz ultrasound transducers were measured to confirm the area of stimulation. The intensity of sound waves transmitted through a Petri-dish was measured in situ for quantitative evaluation. Bromodeoxyuridine (BrdU) incorporation assay was performed to search for appropriate parameters for LIUS stimulation of hAdMSCs. Cell culture medium supplemented with 8% fetal bovine serum (FBS) in a 35 mm Petri-dish was used for 16 days with subculture from 2 to 6 passage. Results: A frequency of 5 MHz, an intensity of 300 , a duration of 10 minutes per day, and continuous waves with 100% duty cycle were the best parameters according to the BrdU assay of proliferation rate of hAdMSCs. LIUS stimulation group had about 3.25-fold greater number of cells from passage 2 to 6 compared with the control group. Doubling time was decreased to 4.44 hours in average. Cell viability was the same between the control and LIUS stimulation groups.Conclusions: This study of enchanced proliferation rate and cell culture productivity of hAdMSCs by LIUS stimulation may lay the foundation for the application of LIUS stimulation in cell therapeutic industry by reducing the production cost and time required for cell therapy.
Synthesis, Characterization And Antimicrobial Activity of Copper-Metal Organic Framework (Cu-MOF) And Its Modification By Melamine
Authors: Abdelmoaty A.S. , El-Beih A.A. , Hanna A.A.
Published: November 2021

Copper- Metal organic framework (Cu-MOF) and melamine/ Cu-MOF (MCu-MOF) samples were prepared by the hydrothermal process. The produced powder was dried and characterized by using the FTIR, X-ray techniques. The thermal gravimetry (TG) analysis was performed to detect the thermal stability of the product. On other hand, the morphology and the surface area of the powder were carried. The bioactivity of the powder was carried by measuring the inhibition zone diameter around samples in (mm). The results of characterization showed that the formation of Cu-MO and melamine/ Cu-MOF in crystalline state in both samples, the surface area of Cu-MOF is equal to 1350 m2 g-1 while increase to 1410 m2 g-1 by incorporate by melamine into the Cu-MOF. The thermal behavior (TG) of the Cu-MOF showed three sequence stages attributed to the moisture evaporation, degradation of the Cu-MOF and forming the Cu-O as end product respectively. For melamine incorporated to Cu-MOF (MCu-MOF), the TG profile shows that the split of the main degradation into two parts resulting from the presence of melamine. The bioactivities of the both samples were tested against microbial strains. The results showed that the Cu-MOF and MCu-MOF have insignificant antimicrobial activity against gram positive of bacteria and Fungi. While for gram negative of bacteria it is observed a considerable effect.
Parent-of-origin effects in the UK Biobank
Authors: Delaneau Olivier , Hofmeister Robin , Rubinacci Simone , Ribeiro Diogo , Kutalik Zoltan , Buil Alfonso
Published: November 2021

Identical genetic variations can have different phenotypic effects depending on their parent of origin (PofO). Yet, studies focussing on PofO effects have been largely limited in terms of sample size due to the need of parental genomes or known genealogies. Here, we used a novel probabilistic approach to infer PofO of individual alleles in the UK Biobank that does not require parental genomes nor prior knowledge of genealogy. Our model uses Identity-By-Descent (IBD) sharing with second- and third-degree relatives to assign alleles to parental groups and leverages chromosome X data in males to distinguish maternal from paternal groups. When combined with robust haplotype inference and haploid imputation, this allowed us to infer the PofO at 5.4 million variants genome-wide for 26,393 UK Biobank individuals. We used this large dataset to systematically screen 59 biomarkers and 38 anthropomorphic phenotypes for PofO effects and discovered 101 significant associations, demonstrating that this type of effects is widespread. Notably, we retrieved well known PofO effects, such as the MEG3/DLK1 locus on platelet count, and we discovered many new ones often at loci outside currently known imprinted regions and previously thought to harbour additive associations, implying that the underlying molecular mechanisms may be more complex than expected.