bluuebunny/crossref_metadata_2025 huggingface dataset:
An animal movement track segmentation framework for forecasting range adaptation under global change
Authors: Getz Wayne M.
Published: June 2023

The methods used for predicting space use and geographic distribution adaptations of animals in response to global change have relied on fitting statistical and machine learning models to environmentally-contextualized movement and spatial distribution data. These predictions, however, are made at particular spatiotemporal scales (from home range to species distribution), but no comprehensive methods have been proposed for predicting how changes to subdiel segments of individual movement tracks may lead to emergent changes in the lifetime tracks of individuals, and hence in the redistribution of species under global change. In this article, we discuss in terms of a hierarchical movement track segmentation framework that, anchored by diel activity routines (DARs), how adaptions in the canonical activity modes (CAMs) of movement can be used to assess space use adaptations to landscape and climate change at scales ranging from subdiel movement segments to the lifetime tracks (LiTs) of individuals.
The response of the brood pouch transcriptome to synthetic estrogen exposure in the Gulf pipefish (Syngnathus scovelli)
Authors: Rose Emily , Johnson Bernadette D. , Armitage Victoria , Jones Adam G.
Published: June 2023

Endocrine disruptors have devastating impacts on the reproductive physiology of aquatic organisms. The Gulf pipefish, Syngnathus scovelli, is a sexually dimorphic species, which demonstrates predictable morphological, physiological, behavioral, and genetic responses to synthetic estrogen exposure. It has a broad geographic range, spanning freshwater and marine environments, making it a potential sentinel species across a wide range of habitats. In this study, we investigated the effects of ecologically relevant levels of 17α-ethinylestradiol (EE2) exposure on gene expression patterns in the male pipefish’s brood pouch. We also characterized the extent to which EE2-exposed males developed coloration patterns that are normally restricted to females. We identified differentially expressed genes in the brood pouches of pregnant and non-pregnant males when males were exposed to 5ng/L EE2 from the second to eighth day of pregnancy (which normally lasts about 2 weeks). Our result revealed several potential candidate genes that have a role in the brood pouch’s response to environmental estrogens. We also identified genes that were differentially expressed between mid-gestation pregnant males and non-pregnant males. We found an overall greater effect of EE2 exposure in the transcriptomes of non-pregnant males, which may explain why estrogen-exposed males exhibited difficulty receiving eggs in previous studies. The offspring developed similarly in the control and estrogen treatments, highlighting a potential link between the timing of EE2 exposure and its effects on male pregnancy. These results provide insight into how breeding pipefish populations may still exist even though they are found in freshwater and coastal locations where they are periodically exposed to potentially high concentrations of endocrine-disrupting compounds. We also present examples of female-typical coloration development on males due to EE2 exposure and identify candidate brood pouch genes that can be utilized as biomarkers, contributing to the development of the Gulf pipefish as a sentinel model for ecotoxicology.
Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals
Authors: Wang Ganggang , Shen Xiaowei , Wang Yicun , Lu Huanhua , He Hua , Wang Xiaoliang
Published: June 2023

Objective

Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide. This study guides the prevention and diagnosis of NAFLD by analyzing its risk factors and the diagnostic value of each index for NAFLD.

Method

We collected the clinical information of adults individuals who underwent physical examination in the Physical Examination Center of Qingpu Branch of Zhongshan Hospital, Fudan University, from January 2016 to January 2020, including gender, age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). We performed logistic regression analysis and ROC diagnostic analysis.

Results

The results showed that age, BMI, SBP, ALT, AST, FBG, TBIL, TG, and LDL were risk factors for NAFLD in adults, and HDL was a protective factor (all p-values were less than 0.05). Among them, age, BMI, ALT, TG, and HDL had a predictive value for the occurrence of NAFLD in the adults (AUC = 0.708, 0.836, 0.767, 0.780, and 0.732, respectively). The combination of age, BMI, ALT, TG, and HDL had a diagnostic value for the occurrence of NAFLD (AUC = 0.881).

Conclusion

Healthy people should pay attention to their BMI levels, manage blood pressure, blood glucose, and lipid levels, and pay attention to changes in ALT and AST index levels to prevent NAFLD. Age, BMI, ALT, TG, and HDL indexes are helpful factors in the diagnosis of NAFLD.
Association between cardiovascular diseases and COVID-19 pneumonia outcome in Indonesia: a multi-center cohort study
Authors: Burhan Erlina , Mubarak Farhan , Adilah Siti Aliyah Said Utriyani , Sari Cut Yulia Indah , Ismail Efriadi , Astuti Puji , Hanifah Yasmina , Wiyarta Elvan , Suryana Nana Maya
Published: June 2023

Background

COVID-19 is a pandemic affecting 185 countries, including Indonesia. Cardiovascular diseases (CVD) in COVID-19 patients were linked to worse clinical outcomes. However, the association remained inconclusive due to limited data in Indonesia. This study aimed to determine the association between CVD in COVID-19 pneumonia patients with its clinical outcomes.

Methods

This retrospective cohort study was conducted in four Indonesian hospitals, enrolling 584 adult COVID-19 pneumonia patients from September 2020 to July 2021. Patients were categorized into two groups: non-CVD and CVD [hypertension, coronary artery disease (CAD), chronic heart failure (CHF), hypertensive heart disease (HHD), arrhythmia, cardiomegaly, left ventricular hypertrophy (LVH), mitral regurgitation (MR), and myocardial injury (MI)]. Clinical outcomes include in-hospital mortality, intensive care unit admission, ventilator use, earlier death, and prolonged hospital stay. Mann–Whitney test was used for analysis.

Results

The most common CVD was hypertension (48.1%), followed by MI (10.6%), CAD (9.2%), CHF (6.8%), HHD (3.1%), arrhythmia (1.7%), and others (0.7%). The in-hospital mortality rate was 24%, and patients were hospitalized for a median of 12 days. MI was the only CVD that increased in-hospital mortality (RR 2.105). It was also significantly increased in patients with diabetes mellitus (RR 1.475) and chronic kidney disease (RR 2.079). Meanwhile, prolonged hospital stay was associated with any CVD (RR 1.553), hypertension (RR 1.511), MI (RR 1.969), CHF (RR 1.595), diabetes mellitus (RR 1.359), and cerebrovascular disease (RR 2.203).

Conclusion

COVID-19 pneumonia in patients with CVD, specifically MI and hypertension, worsens the COVID-19 clinical outcomes.
Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa
Authors: Hannestad Ulf , Apostolou Eirini , Sjögren Per , Bragée Björn , Polo Olli , Bertilson Bo Christer , Rosén Anders
Published: June 2023

The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patient’s tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein–Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.
Optimizing zebrafish rearing−Effects of fish density and environmental enrichment
Authors: Sen Sarma Oly , Frymus Natalia , Axling Fredrik , Thörnqvist Per-Ove , Roman Erika , Winberg Svante
Published: June 2023

Introduction

Despite its popularity in research, there is very little scientifically validated knowledge about the best practices on zebrafish (Danio rerio) husbandry, which has led to several facilities having their own husbandry protocols. This study was performed to expand knowledge on the effects of enrichment and fish density on the welfare of zebrafish, with hopes of providing a scientific basis for future recommendations and legislations.

Methods

Zebrafish were reared at three different stocking densities, (1, 3 or 6 fish/L), in tanks with or without environmental enrichment. Agonistic behavior was observed twice a week for 9 weeks directly in the housing tanks. Aspects of welfare is known to be reflected in neuroendocrine stress responses. Thus, cortisol secretion in response to lowering the water level was analyzed for each group. In addition, we assessed cortisol secretion in response to confinement and risk-taking behavior (boldness) using the novel tank diving test for individual fish. At termination of the experiment fish were subjected to stress by transfer to a novel environment and brain tissue was sampled for analysis of brain monoaminergic activity.

Results

Fish kept at the lowest density (1 fish/L) showed a significantly higher level of aggression than fish kept at 3 or 6 fish/L. Moreover, fish kept at this low density showed significantly higher cortisol secretion on a group level than fish kept at the higher stocking densities, when subjected to lowering of the water level. Keeping fish at 1 fish/L also had effects on brain monoamines, these fish showing higher brain dopamine concentrations but lower dopamine turnover than fish kept at higher densities. Neither stocking density or enrichment had any clear effects on the behavior of individual fish in the novel tank diving test. However, fish kept at high densities showed lower and more variable growth rates than fish kept at 1 fish/L.

Discussion

Taken together these results suggest that zebrafish should not be kept at a density of 1 fish/L. The optimal stocking density is likely to be in the range of 3–6 fish/L.
Graph MADDPG with RNN for multiagent cooperative environment
Authors: Wei Xiaolong , Cui WenPeng , Huang Xianglin , Yang LiFang , Tao Zhulin , Wang Bing
Published: June 2023

Multiagent systems face numerous challenges due to environmental uncertainty, with scalability being a critical issue. To address this, we propose a novel multi-agent cooperative model based on a graph attention network. Our approach considers the relationship between agents and continuous action spaces, utilizing graph convolution and recurrent neural networks to define these relationships. Graph convolution is used to define the relationship between agents, while recurrent neural networks define continuous action spaces. We optimize and model the multiagent system by encoding the interaction weights among agents using the graph neural network and the weights between continuous action spaces using the recurrent neural network. We evaluate the performance of our proposed model by conducting experimental simulations using a 3D wargame engine that involves several unmanned air vehicles (UAVs) acting as attackers and radar stations acting as defenders, where both sides have the ability to detect each other. The results demonstrate that our proposed model outperforms the current state-of-the-art methods in terms of scalability, robustness, and learning efficiency.
Associations between homocysteine and B vitamins and stroke: a cross-sectional study
Authors: Zhang Panpan , Xie Xia , Zhang Yurong
Published: June 2023

Objective

Homocysteine (Hcy) is a predictor for stroke. B vitamins are required for the metabolism of Hcy. We designed a study to investigate the associations of plasma Hcy and B vitamins with the prevalence of stroke in adults.

Methods

A total of 8,371 adults were included in the National Health and Examination Survey (NHANES) between 2003–2006 in the United States. Multivariate regression analysis and smooth curve fitting were conducted to evaluate the associations of stroke prevalence with Hcy, folate, vitamin B6, and B12. A segmented regression model was used to analyze the threshold effects. Sample weights were calculated to ensure the results’ generalizability.

Results

The mean age of all participants was 46.43 years (51.8% women), and the prevalence of stroke was 2.72%. A nonlinear and positive association was found between plasma Hcy levels and the prevalence of stroke. Furthermore, L-shaped associations were found between plasma vitamin B6 and folate levels and stroke, with the turning point at 65.2 nmol/L for vitamin B6 and 26 nmol/L for folate, respectively. Vitamin B12 revealed a U-shaped relationship with stroke, with the turning points at 492.98 pmol/L for vitamin B12.

Conclusion

Non-linear associations of plasma Hcy and B vitamins levels with stroke prevalence were found in American adults. These associations may have an implication that higher plasma Hcy levels should be reduced, and plasma vitamin B6, vitamin B12 and folate levels should be moderately improved in stroke prevention. Future studies are needed to verify the causality of these associations and elucidate the underlying mechanisms.
The role of sleep in neuromuscular disorders
Authors: Angelini Corrado I. , Ansevin Carl , Siciliano Gabriele
Published: June 2023

Sleep represents a major frontier both in clinical myology and as a new possibility for delivering treatment to neuromuscular patients since various neuromuscular cases present a variable degree of disordered sleep and such conditions should be diagnosed and prevented, i.e., sleep apnea and hypoxemia. These sleep disorders are present in dystrophinopathies and in various types of limb-girdle muscular dystrophies (LGMD). Excessive daytime sleepiness (EDS) is found in patients affected by spastic paraparesis or cerebellar ataxia but is rather common in both myotonic dystrophy type 1 and 2, and the correction of sleep disorders is therefore important to improve their daily quality of life (QoL) and consequent daily functioning. Other types of sleep dysfunction such as insomnia, a reduction in rapid eye movement (REM) sleep, loss of normal REM, or sleep-disordered breathing are found in other disorders including myasthenia, ataxias, spastic paraparesis, Charcot–Marie–Tooth disease, and neurogenic disorders, including polyneuropathies, and need appropriate treatment. Research done on this topic aims to incorporate a variety of nuances in metabolic disorders such as those in late-onset Pompe disease and are such as those in late-onset Pompe disease who are susceptible to enzyme replacement therapy (ERT). The overarching goal is to explore both the diagnosis and methodology of sleep-related problems in both genetic and acquired neuromuscular disorders. We also review the type of available treatment opportunities utilized to improve neuromuscular patients’ QoL.
Magnetic resonance spectroscopic correlates of progression free and overall survival in “glioblastoma, IDH-wildtype, WHO grade-4”
Authors: Sacli-Bilmez Banu , Danyeli Ayça Erşen , Yakicier M. Cengiz , Aras Fuat Kaan , Pamir M. Necmettin , Özduman Koray , Dinçer Alp , Ozturk-Isik Esin
Published: June 2023

Background

The 2021 World Health Organization (WHO) Central Nervous System (CNS) Tumor Classification has suggested that isocitrate dehydrogenase wildtype (IDH-wt) WHO grade-2/3 astrocytomas with molecular features of glioblastoma should be designated as “Glioblastoma, IDH-wildtype, WHO grade-4.” This study analyzed the metabolic correlates of progression free and overall survival in “Glioblastoma, IDH-wildtype, WHO grade-4” patients using short echo time single voxel 1H-MRS.

Methods

Fifty-seven adult patients with hemispheric glioma fulfilling the 2021 WHO CNS Tumor Classification criteria for “Glioblastoma, IDH-wildtype, WHO grade-4” at presurgery time point were included. All patients were IDH1/2-wt and TERTp-mut. 1H-MRS was performed on a 3 T MR scanner and post-processed using LCModel. A Mann–Whitney U test was used to assess the metabolic differences between gliomas with or without contrast enhancement and necrosis. Cox regression analysis was used to assess the effects of age, extent of resection, presence of contrast enhancement and necrosis, and metabolic intensities on progression-free survival (PFS) and overall survival (OS). Machine learning algorithms were employed to discern possible metabolic patterns attributable to higher PFS or OS.

Results

Contrast enhancement (p = 0.015), necrosis (p = 0.012); and higher levels of Glu/tCr (p = 0.007), GSH/tCr (p = 0.019), tCho/tCr (p = 0.032), and Glx/tCr (p = 0.010) were significantly associated with shorter PFS. Additionally, necrosis (p = 0.049), higher Glu/tCr (p = 0.039), and Glx/tCr (p = 0.047) were significantly associated with worse OS. Machine learning models differentiated the patients having longer than 12 months OS with 81.71% accuracy and the patients having longer than 6 months PFS with 77.41% accuracy.

Conclusion

Glx and GSH have been identified as important metabolic correlates of patient survival among “IDH-wt, TERT-mut diffuse gliomas” using single-voxel 1H-MRS on a clinical 3 T MRI scanner.
Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve
Authors: Chen Szu-Han , Wu Chia-Ching , Tseng Wan-Ling , Lu Fu-I , Liu Ya-Hsin , Lin Shau-Ping , Lin Sheng-Che , Hsueh Yuan-Yu
Published: June 2023

Introduction

Compressive neuropathy, a common chronic traumatic injury of peripheral nerves, leads to variable impairment in sensory and motor function. Clinical symptoms persist in a significant portion of patients despite decompression, with muscle atrophy and persistent neuropathic pain affecting 10%–25% of cases. Excessive inflammation and immune cell infiltration in the injured nerve hinder axon regeneration and functional recovery. Although adipose-derived stem cells (ASCs) have demonstrated neural regeneration and immunomodulatory potential, their specific effects on compressive neuropathy are still unclear.

Methods

We conducted modified CCI models on adult male Sprague-Dawley rats to induce irreversible neuropathic pain and muscle atrophy in the sciatic nerve. Intraneural ASC injection and nerve decompression were performed. Behavioral analysis, muscle examination, electrophysiological evaluation, and immunofluorescent examination of the injured nerve and associated DRG were conducted to explore axon regeneration, neuroinflammation, and the modulation of inflammatory gene expression. Transplanted ASCs were tracked to investigate potential beneficial mechanisms on the local nerve and DRG.

Results

Persistent neuropathic pain was induced by chronic constriction of the rat sciatic nerve. Local ASC treatment has demonstrated robust beneficial outcomes, including the alleviation of mechanical allodynia, improvement of gait, regeneration of muscle fibers, and electrophysiological recovery. In addition, locally transplanted ASCs facilitated axon remyelination, alleviated neuroinflammation, and reduced inflammatory cell infiltration of the injured nerve and associated dorsal root ganglion (DRG). Trafficking of the transplanted ASC preserved viability and phenotype less than 7 days but contributed to robust immunomodulatory regulation of inflammatory gene expression in both the injured nerve and DRG.

Discussion

Locally transplanted ASC on compressed nerve improve sensory and motor recoveries from irreversible chronic constriction injury of rat sciatic nerve via alleviation of both local and remote neuroinflammation, suggesting the promising role of adjuvant ASC therapies for clinical compressive neuropathy.
Design and implementation of high sampling rate and multichannel wireless recorder for EEG monitoring and SSVEP response detection
Authors: Li Ruikai , Zhang Yixing , Fan Guangwei , Li Ziteng , Li Jun , Fan Shiyong , Lou Cunguang , Liu Xiuling
Published: June 2023

Introduction

The collection and process of human brain activity signals play an essential role in developing brain-computer interface (BCI) systems. A portable electroencephalogram (EEG) device has become an important tool for monitoring brain activity and diagnosing mental diseases. However, the miniaturization, portability, and scalability of EEG recorder are the current bottleneck in the research and application of BCI.

Methods

For scalp EEG and other applications, the current study designs a 32-channel EEG recorder with a sampling rate up to 30 kHz and 16-bit accuracy, which can meet both the demands of scalp and intracranial EEG signal recording. A fully integrated electrophysiology microchip RHS2116 controlled by FPGA is employed to build the EEG recorder, and the design meets the requirements of high sampling rate, high transmission rate and channel extensive.

Results

The experimental results show that the developed EEG recorder provides a maximum 30 kHz sampling rate and 58 Mbps wireless transmission rate. The electrophysiological experiments were performed on scalp and intracranial EEG collection. An inflatable helmet with adjustable contact impedance was designed, and the pressurization can improve the SNR by approximately 4 times, the average accuracy of steady-state visual evoked potential (SSVEP) was 93.12%. Animal experiments were also performed on rats, and spike activity was captured successfully.

Conclusion

The designed multichannel wireless EEG collection system is simple and comfort, the helmet-EEG recorder can capture the bioelectric signals without noticeable interference, and it has high measurement performance and great potential for practical application in BCI systems.
Exploring the correlation between genetic transcription and multi-temporal developmental autism spectrum disorder using resting-state functional magnetic resonance imaging
Authors: Li Yanling , Zhou Fanchao , Li Rui , Gu Jiahe , He Jiangping
Published: June 2023

Introduction

The present investigation aimed to explore the neurodevelopmental trajectory of autism spectrum disorder (ASD) by identifying the changes in brain function and gene expression associated with the disorder. Previous studies have indicated that ASD is a highly inherited neurodevelopmental disorder of the brain that displays symptom heterogeneity across different developmental periods. However, the transcriptomic changes underlying these developmental differences remain largely unknown.

Methods

To address this gap in knowledge, our study employed resting-state functional magnetic resonance imaging (rs-fMRI) data from a large sample of male participants across four representative age groups to stratify the abnormal changes in brain function associated with ASD. Partial least square regression (PLSr) was utilized to identify unique changes in gene expression in brain regions characterized by aberrant functioning in ASD.

Results

Our results revealed that ASD exhibits distinctive developmental trajectories in crucial brain regions such as the default mode network (DMN), temporal lobe, and prefrontal lobes during critical periods of neurodevelopment when compared to the control group. These changes were also associated with genes primarily located in synaptic tissues.

Discussion

The findings of this study suggest that the neurobiology of ASD is uniquely heterogeneous across different ages and may be accompanied by distinct molecular mechanisms related to gene expression.
The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development
Authors: Clement Amalie , Christensen Sarah Louise , Jansen-Olesen Inger , Olesen Jes , Guo Song
Published: June 2023

Migraine is one of the leading causes of disability worldwide, affecting work and social life. It has been estimated that sales of migraine medicines will reach 12.9 billion USD in 2027. To reduce social impact, migraine treatments must improve, and the ATP-sensitive potassium (KATP) channel is a promising target because of the growing evidence of its implications in the pathogenesis of migraine. Strong human data show that opening of the KATP channel using levcromakalim is the most potent headache and migraine trigger ever tested as it induces headache in almost all healthy subjects and migraine attacks in 100% of migraine sufferers. This review will address the basics of the KATP channel together with clinical and preclinical data on migraine implications. We argue that KATP channel blocking, especially the Kir6.1/SUR2B subtype, may be a target for migraine drug development, however translational issues remain. There are no human data on the closure of the KATP channel, although blocking the channel is effective in animal models of migraine. We believe there is a good likelihood that an antagonist of the Kir6.1/SUR2B subtype of the KATP channel will be effective in the treatment of migraine. The side effects of such a blocker may be an issue for clinical use, but the risk is likely only moderate. Future clinical trials of a selective Kir6.1/SUR2B blocker will answer these questions.
Increased newborn NICU admission for evaluation of hypoxic-ischemic encephalopathy during COVID-19 pandemic in a public hospital
Authors: Song Dongli , Narasimhan Sudha Rani , Huang Angela , Jegatheesan Priya
Published: June 2023

Background

Prenatal and perinatal care of pregnant mothers has been adversely affected during the COVID-19 pandemic. Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal death and long-term neurological disabilities. Therapeutic hypothermia is effective for neonatal HIE. This study evaluated the effect of the pandemic on neonatal HIE.

Methods

This retrospective single-center study compared neonatal HIE evaluation and hypothermia treatment between pre-COVID-19 pandemic (1 January 2018–31 December 2019) and COVID-19 pandemic (1 January 2020–31 December 2021) periods. Infants with abnormal neurological examination and or significant metabolic acidosis were admitted to NICU for evaluation of HIE and therapeutic hypothermia. Demographics, NICU admission and interventions, and neonatal outcomes were compared between infants born during the two periods using χ2, t-test, and Wilcoxon rank-sum test as appropriate. Statistical Process Control charts show the yearly proportion of infants evaluated for HIE and those treated with therapeutic hypothermia.

Results

From the pre-pandemic to the pandemic period, the proportion of infants that met HIE screening criteria increased from 13% to 16% (p < 0.0001), the proportion of infants admitted to NICU for HIE evaluation increased from 1% to 1.4% (p = 0.02), and the maternal hypertension rates of the admitted infants increased from 30% to 55% (p = 0.006). There was no difference in the proportions of the infants diagnosed with HIE (0.7% vs. 0.9%, p = 0.3) or treated with therapeutic hypothermia (0.2% vs. 0.3%, p = 0.3) between the two periods. There were no differences in the HIE severity and outcomes of the infants treated with therapeutic hypothermia between the two periods.

Conclusion

During the COVID-19 pandemic, we observed a significant increase in NICU admission for HIE evaluation. While we did not find significant increases in neonatal HIE and the need for therapeutic hypothermia, larger studies are needed for a comprehensive assessment of the impact of the COVID-19 pandemic on neonatal HIE.
Seeking support through solidarity: female leader’s experiences of workplace solidarity in male-dominated professions
Authors: Pillay-Naidoo Daphne , Vermeulen Corlette
Published: June 2023

Introduction

While there is a plethora of research that documents the numerous barriers affecting female leaders in the modern workplace, there is a lack of literature which focuses on strategies or motivating resources that women use to navigate the workplace environment. Despite facing significant barriers in their leadership journeys, there are female leaders who are able to overcome these barriers to achieve leadership positions. These women leaders draw on personal and external motivating factors to assist them in dealing with the challenges associated with being a female leader as a result, research on motivating strategies for women’s career progression is a research topic that warrants immediate attention. Female solidarity as a motivating resource has been gaining traction in the field of leadership studies and can be seen as a supportive resource that can be used by current and aspiring female leaders to progress in underrepresented environments. Although female solidarity is but only one of the many strategies that can be implemented to motivate women in leadership positions, the increase of female solidarity in the workplace is expected to alleviate the conditions that reinforce essentialist notions of the “queen bee syndrome” in which women are seen as unsupportive of each other.

Method

A qualitative research approach was used for this study, following an interpretive descriptive design. A total of 13 semi-structured interviews were conducted with female leaders in male-dominated professions within South Africa. Data was analysed using thematic content analysis.

Results

Results of the study were analyzed in line with three primary content areas, i.e., barriers to female solidarity in the workplace, benefits of female solidarity in the workplace and workplace interventions to increase solidarity.

Discussion

In the context of the study the predominant barriers to female solidarity within male-dominated workplaces were identified as unfair workplace behaviours, generational beliefs, societal expectations, organisational cultures, stereotypes and stigmas. The benefits of female solidarity within male-dominated workplaces were identified as career shaping mentorship, female recognition, female representation and female support. Lastly, the interventions that can be implemented to increase female solidarity within male-dominated workplaces were conceptualised as networking, transforming the company culture, socialisation and mentorship.
Can you imagine this? Imagined contact as a strategy to promote positive intergroup relations
Authors: Shamoa-Nir Lipaz , Razpurker-Apfeld Irene
Published: June 2023

In comparison to the extensive body of research on intergroup contact, which encompasses predictors, outcomes, and implications, there has been relatively little attention given to the role of imagined contact with diverse ethno-religious out-groups. This gap particularly exists in understanding the factors that contribute to the effectiveness of imagined contact interventions. This article aims to address this gap by presenting current research on the predictors and consequences of imagined contact. We offer an overview of the circumstances in which imagined contact proves beneficial; while focusing on research that holds relevance for designing interventions and policies promoting contact between culturally and religiously diverse groups and individuals. We also acknowledge the existing limitations within this field of study and propose potential direction for future research.
Mental health, self-rated health, risky sexual behaviour, alcohol use, and drug use among students who intend to spend a semester abroad – a cross-sectional study
Authors: Danehorn Emil , Peterson Ulla , Oscarsson Marie , Smirthwaite Goldina , Swahnberg Katarina
Published: June 2023

Aim

Our aim was to investigate potential differences in mental health, self-rated health, risky sexual behaviour, alcohol use, and drug use between (1) Prospective exchange students and campus students separated by sex, and (2) male and female students as a group.

Method

Comparative cross-sectional design using an online survey containing the following instruments: Knowledge, Attitudes, and Sexual Behaviour in Young People in Sweden; Self-Rated Health Questionnaire; and General Health Questionnaire 12. One-hundred and fourteen prospective exchange students and 451 campus students participated in the study.

Results

Male prospective exchange students rated their mental health as being better and had used cannabis more often compared with female prospective exchange students. Male prospective exchange students also rated their mental health as being better than male campus students. Female students, in general, rated their mental health as worse than male students. A larger proportion of male prospective exchange students had sex together with alcohol compared with male campus students, and a larger proportion of female prospective exchange students had sex with a new partner and drank more alcohol compared to female campus students.

Conclusion

The result shows that risky alcohol use and sexually risky behaviour is prominent amongst prospective exchange students. It is possible that they will continue, and even increase their risky behaviour whilst abroad as they find themselves in a new social context, and free from influence of the rules and restrictions that they might have at home. With limited knowledge of the local culture, native language, and in an unfamiliar environment, it is possible that the risks will be enhanced and possibly decrease their health. This highlights the need for proactive interventions, conceivably with some variations in content between sexes.
Testicular pathological alterations associated with SARS-CoV-2 infection
Authors: Ly Judy , Campos Rafael K. , Hager-Soto E. Eldridge , Camargos Vidyleison N. , Rossi Shannan L.
Published: June 2023

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to date. Due to its potential for airborne transmission, many studies have focused on SARS-CoV-2 primarily as a respiratory disease. However, the spread of SARS-CoV-2 to non-respiratory organs has been experimentally demonstrated and clinically observed. During autopsy studies, histopathological lesions, and disruption of the blood-testes barrier (BTB) have been observed in the male reproductive tract. Here, we review findings from both autopsy cases and animal models that demonstrate testicular disease due to COVID-19 and present an overview of the pathological alterations that occur in the testes resulting from SARS-CoV-2 infection and explore its potential mechanisms.
Assessing the adoption of regenerative agricultural practices in Eastern Africa
Authors: Ntawuhiganayo Elisée Bahati , Nijman-Ross Elke , Geme Tom , Negesa Doryn , Nahimana Samuel
Published: June 2023

Food security remains a challenge for Africa and regenerative agricultural practices can play an important role in building resilience while sustaining agricultural production and preserving diversity of ingredients and rich biodiversity. This study conducted surveys in eight regions in East Africa, four in Rwanda and four in Kenya, to understand how circular principles are applied in agriculture, potential drivers of the adoption of regenerative agriculture and its contribution to household food security. A binary logistic regression model was used to capture the influence of independent variables on the adoption of regenerative agricultural practices and determining factors of household food security. The findings suggest that farming households engage in less than four different practices, mainly in less labor-intensive practices such as crop rotation and intercropping. Household food security increased with an increased number of regenerative agricultural practices applied by the household and increased frequency of farm visits by extension agents. Regenerative agriculture practices, when applied in combinations, have the potential to increase household food security. This study recommends designing scaling-up pathways to accelerate the transition to regenerative agriculture and build a more resilient food system in East Africa.
Factors influencing disaster response behavior of international tourists under the Tokyo Metropolitan Earthquake scenario
Authors: Choi Sunkyung , Yoshida Kozo , Yamaji Hideyuki , Shindo Hiroaki , Maharjan Rajali
Published: June 2023

As Japan continues to become a popular global tourism destination, its vulnerability to disasters cannot be overlooked. Although the Japanese government has implemented different disaster prevention policies and practices, there is a lack of investigation into disaster response behaviors, such as information seeking, evacuation, and the factors affecting these. This study clarified the factors influencing the disaster response behavior of international tourists in the context of the anticipated Tokyo Metropolitan Earthquake scenario. A questionnaire survey was conducted, and the logistic regression model was used to understand the causative factors. The results revealed that the variable knowledge on disaster response behavior in earthquakes influences individuals' evacuation decisions, especially when people choose to follow others. These findings will be beneficial for tourism stakeholders and policymakers to establish effective tourism crisis management planning, including information provision, shelter allocation, and collaborative initiatives.
The Relationship Between Social Capital and Sleep Duration Among Older Adults in Ghana: A Cross-Sectional Study
Authors: Nutakor Jonathan Aseye , Zhou Lulin , Larnyo Ebenezer , Gavu Alexander Kwame , Chohan Irfan Mir , Addai-Dansoh Stephen , Tripura Debashree
Published: June 2023

Objective: This study aims to investigate the connection between social capital and sleep duration among older adults in Ghana, as limited research has been conducted to explore this relationship.

Methods: This study utilized Wave 2 data from a sample of Ghanaian older adults from the World Health Organization Study on Global AGEing and Adult Health (SAGE). Self-reported data on social capital and sleep duration were compiled. Using ordered logistic regression, the relationship between social capital and sleep duration was examined.

Results: Older adults who did not participate in social activities showed the strongest association with the risk of short sleep (p < 0.05). Our study found that older adults who sleep for shorter periods tend to report better sleep quality. There was no correlation between medium and long sleep durations and social capital.

Conclusion: This study underscores the importance of more research to truly understand the complex connections between older adults’ social participation, sleep, and health. It also has important implications for the promotion of good sleep in aging populations.
Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi
Authors: Yaremenko Ivan A. , Radulov Peter S. , Belyakova Yulia Yu. , Fomenkov Dmitrii I. , Vil’ Vera A. , Kuznetsova Maria A. , Demidova Valentina N. , Glinushkin Alexei P. , Terent’ev Alexander O.
Published: June 2023

The search for new classes of fungicides has long been important in plant protection due to the development of fungal resistance to currently used agrochemicals. Organic peroxides have long been regarded as exotic and unstable compounds. The discovery of the antimalarial activity of the peroxide natural product Artemisinin, an achievement that was recently recognized with the Nobel Prize, has brought organic peroxides into the medicinal and agrochemistry. In this paper, fungicidal activity of synthesized organic peroxides—geminal bishydroperoxide, bridged 1,2,4,5-tetraoxanes, and tricyclic monoperoxides—were tested in vitro against an important species of phytopathogenic fungi (F. culmorum, R. solani, A. solani, P. infestans, C. coccodes). We discovered that substituted bridged 1,2,4,5-tetraoxanes exhibit fungicidal activity comparable or superior to azoxystrobin and superior to geminal bishydroperoxide and tricyclic monoperoxides. The contact mode of action was demonstrated for the bridged 1,2,4,5-tetraoxane.
Special Issue on Remote Sensing Applications in Archaeology, Geography, and the Earth Sciences
Authors: Su Tung-Ching
Published: June 2023

Remote sensing has played a pivotal role in advancing the fields of archaeology, geography, and earth sciences, offering new perspectives and unparalleled opportunities for research, analysis, and interpretation within these disciplines [...]
Model of Neuromorphic Odorant-Recognition Network
Authors: Stasenko Sergey V. , Mikhaylov Alexey N. , Kazantsev Victor B.
Published: June 2023

We propose a new model for a neuromorphic olfactory analyzer based on memristive synapses. The model comprises a layer of receptive neurons that perceive various odors and a layer of “decoder” neurons that recognize these odors. It is demonstrated that connecting these layers with memristive synapses enables the training of the “decoder” layer to recognize two types of odorants of varying concentrations. In the absence of such synapses, the layer of “decoder” neurons does not exhibit specificity in recognizing odorants. The recognition of the ’odorant’ occurs through the neural activity of a group of decoder neurons that have acquired specificity for the odorant in the learning process. The proposed phenomenological model showcases the potential use of a memristive synapse in practical odorant recognition applications.
The Effect of Steel Trusses on the Mechanical Performance of Laminated Precast Slabs
Authors: Xin Gongfeng , Long Guanxu , Zhao Jizhi , Zhang Zejun
Published: June 2023

Laminated concrete slabs can deliver desirable structural properties and effectively improve the speed of construction. According to their basic specifications, laminated concrete slabs comprise a 60 mm precast concrete slab and a 70 mm concrete layer cast in situ, with a steel truss bar at a height of 80 mm. This paper studies the effects of the steel truss bar on the mechanical properties of precast slabs. A simple but accurate method is proposed for calculating the stiffness of precast slabs. The test results show that the steel truss bar has a limited effect on the stiffness of the precast slab but will weaken the compression strength of the concrete, resulting in a significant reduction in the ultimate bearing capacity of the precast slab. Further discussions show that eliminating the steel truss bar and appropriately increasing the thickness of the precast slab can effectively increase the stiffness and load-bearing capacity of the precast slab, as well as reduce the consumption of the floor reinforcement by about 26%.
Notes on Graphidaceae in Macaronesia, with Descriptions of Four New Species
Authors: van den Boom Pieter P. G. , Lücking Robert , Sipman Harrie J. M.
Published: June 2023

A survey of the lichen family Graphidaceae in Macaronesia (Madeira, the Canary Islands, and the Azores) is presented, with detailed treatments for the genera Allographa, Fissurina, and Graphis. All other species are listed and new records provided. A key to all Graphicacy known from Macaronesia, except the thelotremoid species, is presented. The following species are newly described: Fissurina azorica, Fissurina elaiocarpoides, Fissurina nigrolabiata, and Topeliopsis juniperina. Many species are newly recorded for one or more islands of the three archipelagos.
Concordance between Clinical and Pathological T and N Stages in Polish Patients with Head and Neck Cancers
Authors: Chloupek Aldona , Kania Joanna , Jurkiewicz Dariusz
Published: June 2023

Background: The TNM (tumor, node, metastasis) staging system is important for the successful treatment of head and neck cancers (HNCs). This study aimed to evaluate the concordance between clinical and pathological T and N stages in patients with HNCs in Poland. Methods: In this single-center retrospective study, clinical and pathological TNM staging data on 203 patients undergoing surgical treatment for HNC between 2011 and 2018 were collected and compared. The study group was classified as underdiagnosed, overdiagnosed, or correctly diagnosed with HNC based on pathological TNM staging. The concordance between clinical and pathological staging was evaluated using the kappa coefficient. Results: Clinical and pathological TNM staging showed concordance in 59.9% of patients for primary tumor (T) and in 79.3% of patients for lymph node (N) classifications. Moderate agreement between the clinical and pathological stages was shown for stage T, while substantial agreement was revealed for stage N. The size and extent of the tumor were underestimated or overestimated in 73 of the 182 patients (40.1%), while lymph node involvement was downstaged in 11 of the 53 patients (20.7%). Conclusions: The disparities between clinical and pathological staging of HNC demonstrate the need for standardization in physical and pathological examinations, as well as radiographic imaging.
Deep-Learning-Based Cryptanalysis of Lightweight Block Ciphers Revisited
Authors: Kim Hyunji , Lim Sejin , Kang Yeajun , Kim Wonwoong , Kim Dukyoung , Yoon Seyoung , Seo Hwajeong
Published: June 2023

With the development of artificial intelligence, deep-learning-based cryptanalysis has been actively studied. There are many cryptanalysis techniques. Among them, cryptanalysis was performed to recover the secret key used for cryptography encryption using known plaintext. In this paper, we propose a cryptanalysis method based on state-of-art deep learning technologies (e.g., residual connections and gated linear units) for lightweight block ciphers (e.g., S-DES, S-AES, and S-SPECK). The number of parameters required for training is significantly reduced by 93.16%, and the average of bit accuracy probability increased by about 5.3% compared with previous the-state-of-art work. In addition, cryptanalysis for S-AES and S-SPECK was possible with up to 12-bit and 6-bit keys, respectively. Through this experiment, we confirmed that the-state-of-art deep-learning-based key recovery techniques for modern cryptography algorithms with the full round and the full key are practically infeasible.
Aftershocks and Fluctuating Diffusivity
Authors: Abe Sumiyoshi , Suzuki Norikazu , Tayurskii Dmitrii A.
Published: June 2023

The Omori-Utsu law shows the temporal power-law-like decrease of the frequency of earthquake aftershocks and, interestingly, is found in a variety of complex systems/phenomena exhibiting catastrophes. Now, it may be interpreted as a characteristic response of such systems to large events. Here, hierarchical dynamics with the fast and slow degrees of freedom is studied on the basis of the Fokker-Planck theory for the load-state distribution to formulate the law as a relaxation process, in which diffusion coefficient in the space of the load state is treated as a fluctuating slow variable. The evolution equation reduced from the full Fokker-Planck equation and its Green’s function are analyzed for the subdynamics governing the load state as the fast degree of freedom. It is shown that the subsystem has the temporal translational invariance in the logarithmic time, not in the conventional time, and consequently the aging phenomenon appears.