bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the force applied by the adductor muscles in a healthy student population performing an adduction task
Authors: Cruz Maria , Rasteiro Deolinda , Carvalho Filipe , Lains Jorge , Roseiro Luis
Published: August 2021

Background

The adduction and abduction movement (closing and open the legs) are important tasks in daily activities. The evaluation and monitor of the force exerted by the adductor muscles can be used as a rehabilitation progress indicator, particularly in people with injuries in the central nervous system or motor neurons. The development of biomechanical devices to quantify and identify patterns in this type of force with healthy people can be a contribution in this domain. This work, approved by the Ethical Committee of IPC, aims to evaluate the force applied by the adductor muscles from a healthy group of students, performing the closing legs task.

Methods

The study was carried out at Applied Biomechanics Laboratory of IPC, with a group of 32 healthy volunteers from the student community (19-26 yo), half men - half women, without lower limb injuries, 59,38% with a prevalence of sedentary lifestyle. Volunteers, sitting in a comfortable position, press a biomechanical device placed between the legs. The time-force was registered for four discrete open-leg positions.

Results

The maximum mean forces were 199N in women and 257N in men, both in the shorter range of the open-leg position. The peak of force decreases with open leg distance for both genders and was achieved between 34%–54% of the performance time ([3, 28] seconds). Moderate correlations were identified between forces applied and skeletal muscles and resting metabolism.

Conclusion

The time-force applied was identified and registered with a developed biomechanical device. Obtained values are reliable and can be a support for future investigations.
1. Doing Political Philosophy
Authors: Abel William , Kahn Elizabeth , Parr Tom , Walton Andrew
Published: August 2021

This chapter provides an overview of how to do political philosophy. It identifies some of the main aims of the discipline, showing that one can make progress with the subject by studying arguments about the justifiability of various public policies. Political philosophers are mostly concerned with exploring the moral claims of an argument, and the relationship between an argument’s claims and its conclusion. It is here that the discipline connects to other parts of philosophy, particularly moral philosophy and logic. This chapter discusses two tools in the practice of political philosophy. One of these involves arranging arguments in clear and organized terms, and the other involves the use of examples and thought experiments in the analysis of moral claims. The chapter then discusses how to employ these tools in the service of a political argument.
4. Recreational Drugs and Paternalism
Authors: Abel William , Kahn Elizabeth , Parr Tom , Walton Andrew
Published: August 2021

This chapter explores whether it is justifiable for a state to discourage an individual from using recreational drugs. It focuses on paternalist arguments—that is, arguments that appeal to the idea that a state may intervene in an individual’s life for their own good. The chapter argues against the justifiability of these policies, except in some extreme cases. It offers three arguments for the anti-paternalist claim that a state may not intervene in an individual’s life for their own good. These are that there is value in an individual acting autonomously; that it is disrespectful to intervene in an individual’s life for their own good; and that an individual is a better judge of their interests than the state. The chapter also examines whether it is justifiable for a state to intervene in an individual’s life for their own good when that individual is misinformed about the options. In the case of recreational drugs, the appropriate response to misinformation is to educate an individual about the effects of drugs, rather than to discourage their use. Finally, the chapter outlines some implications of this argument for the design of drug policy.
12. Intensive Animal Farming and Moral Status
Authors: Abel William , Kahn Elizabeth , Parr Tom , Walton Andrew
Published: August 2021

This chapter studies which principles should govern the state’s regulation of the treatment of non-human animals raised for human consumption. It defends the claim that it is wrong to inflict pain on or to kill animals, and that the state should prohibit intensive animal farming on these bases. The chapter then considers the objection that there is no moral duty to act in this way because animals are not part of the relevant community of moral concern. It demonstrates that it is implausible to restrict the scope of moral duties in this way. Finally, the chapter explores the claim that it would be wrong for the state to enforce compliance with these duties, but it contends that limiting the state’s role in this way leads to various implausible conclusions regarding how it should regulate the treatment of both animals and humans.
14. Immigration and the Political Community
Authors: Abel William , Kahn Elizabeth , Parr Tom , Walton Andrew
Published: August 2021

This chapter argues against policies that restrict immigration. It contends that states should have open borders that allow an individual to move between political communities. The chapter begins by defending a presumption in favour of open borders that appeals to the value of freedom of movement. It then responds to those who deny that freedom of movement is sufficiently important to generate such a presumption, as well as to those who insist that states enjoy a prerogative over whether or not to grant an individual the opportunity to migrate. The chapter considers a range of objections that emphasize how open borders can jeopardize the security, economy, and culture of receiving states, showing that a proper concern for these values is consistent with borders that are largely (even if not fully) open.
16. Humanitarian Intervention and Political Self-Determination
Authors: Abel William , Kahn Elizabeth , Parr Tom , Walton Andrew
Published: August 2021

This chapter argues that there is a just cause to intervene militarily in a state that systematically violates the human rights of its members. It rejects the views of those who contend that there is no justification for humanitarian intervention because there are no universal moral values. The chapter accepts that the value of political self-determination can explain what is wrong with humanitarian intervention in some cases. However, appeals to this value are decisive less often than many critics of intervention suppose. One concern with adopting a permissive attitude towards humanitarian intervention is that this might be open to misuse. The chapter then articulates a role for international law in authorizing intervention to minimize this risk. It concludes by clarifying how these arguments fit within a wider set of considerations pertinent to the justifiability of humanitarian intervention.
6. Global environmental governance and climate change
Authors: Scicluna Nicole
Published: August 2021

This chapter focuses on the intersection of law and politics in global environmental governance. A key characteristic of global environmental governance is its fragmentation. The regulatory landscape is populated by a variety of hard and soft law regimes, institutions, processes, and actors, which address particular environmental challenges, or address them in particular ways. Yet there are core principles that are common to many of these regimes, including the precautionary principle, the prevention principle, the principle of common but differentiated responsibilities, and the concept of sustainable development. The chapter then turns to an in-depth analysis of global climate change governance. It traces the evolution of climate change governance from the creation of the UN Framework Convention on Climate Change in 1994 to the present, focusing on the major legal-institutional milestones of the 1997 Kyoto Protocol and the 2015 Paris Agreement. Finally, the chapter returns to the problem of fragmentation, considering recent attempts to bring greater unity and coherence to global environmental governance.
9. States, nations, and colonies
Authors: Scicluna Nicole
Published: August 2021

This chapter investigates how-and how effectively-international law strikes a balance between the individual and collective rights of people, and the prerogatives of sovereign states. It begins by exploring the what, who, and where of self-determination. Self-determination is a concept that has meant different things to different people at different times. Its meaning under international law can only be understood in relation to the shifting paradigms of international politics in the twentieth and twenty-first centuries. The chapter discusses the Wilsonian principle of self-determination and its partial application during the interwar period. It then turns to the post-Second World War rebirth of self-determination as a right of colonized peoples to independent statehood. The chapter also considers the concept of internal self-determination, before analysing what external self-determination has come to mean in non-colonial contexts and the problem of remedial secession. Finally, it examines the law and politics of recognition of statehood.
13. International criminal justice
Authors: Scicluna Nicole
Published: August 2021

This chapter assesses whether international politics can be conducted in the courtroom. It begins with an analysis of the post-Second World War Nuremberg tribunal. While flawed in many ways, these proceedings marked a significant change in thinking about international crimes and individual responsibility. Though the onset of the Cold War prevented the translation of the Nuremberg legacy into more permanent, treaty-based international institutions, the ideas Nuremberg incubated were to have a lasting impact on international law. As in so many other areas of international law and international politics, the end of the Cold War was a watershed. The 1990s saw the revival of ad hoc international criminal tribunals, most notably the International Criminal Tribunal for Yugoslavia and the International Criminal Tribunal for Rwanda. The chapter then examines the International Criminal Court, which is, in many ways, the culmination of efforts to institutionalize international criminal justice.
3. The EU Policy Process in Comparative Perspective
Authors: Young Alasdair R. , Roederer-Rynning Christilla
Published: August 2021

This chapter examines the European Union’s policy-making process with a comparative perspective. It outlines the stages of the policy-making process (agenda-setting, policy formation, decision-making, implementation, and policy feedback) and considers the prevailing approaches to analysing each of these stages. It also shows how these approaches apply to studying policy-making in the EU. Themes addressed in this chapter include policy-making and the policy cycle, the players in the policy process, executive politics, legislative politics, and judicial politics. The chapter argues that theories rooted in comparative politics and international relations can help elucidate the different phases of the EU’s policy process. It concludes by explaining why policy-making varies across issue areas within the EU.
4. An Institutional Anatomy and Five Policy Modes
Authors: Wallace Helen , Reh Christine
Published: August 2021

This chapter examines the European Union’s institutional design and how its institutions interact with national institutions in five different policy modes. The chapter first considers the evolving role and internal functioning of the European Commission, Council of the EU, European Council, European Parliament, and Court of Justice of the European Union (CJEU). It also discusses quasi-autonomous agencies, in particular the European Central Bank (ECB), institutionalized control and scrutiny, and non-state actors. The chapter then offers an analysis of five policy modes that capture the different patterns of interaction between the EU and its member states: the classical Community method, the regulatory mode, the distributional mode, policy coordination, and intensive transgovernmentalism.
11. Social Policy
Authors: Bachtler John , Mendez Carlos
Published: August 2021

Social policy in the European Union (EU) is characterized by a fundamental puzzle: integration has happened despite member-state opposition to the delegation of welfare competences. While the policy has developed in small and modest steps, over time, this has led to a considerable expansion of the policy remit. Negative integration pushed by judicial decision-making is often regarded as a main driver for social integration. Positive integration through EU legislation is, however, just as defining for EU social policy, and politics is very evident when EU member states negotiate social regulation. More recently, the policy has been marked by deep politicization.
18. International Development
Authors: Orbie Jan
Published: August 2021

The European Union (EU) is widely recognized to be a major actor in international development cooperation. First, this chapter discusses key issues and debates in EU development policy. These relate to the importance of the EU in this field, the different objectives that it pursues, the aid budgets at its disposal, and the legal competences vis-à-vis the member states. Secondly, the uniqueness of this policy domain, compared to other EU policies in this volume, is addressed. Specifically, it highlights three distinctive features: the availability of budgetary power outside the EU, the long historical legacy dating back to member states’ colonial past, and the key role of trade as the preferred tool for development. Thirdly, the chapter elaborates two main policy-making domains: the EU as a donor itself and as a coordinator of member states’ policies. Overall, the EU follows the regulatory and distributional modes in its role as a donor, and when it seeks to coordinate member-state policy, the policy coordination mode is to the fore. Moreover, intensive transgovernmentalist features appear in both domains. The conclusion summarizes the main trends and future challenges including the implications of Brexit, the rise of China, and the increasing politicization of aid.
1. Electoral Systems
Authors: Pilet Jean-Benoit , Renwick Alan
Published: August 2021

This chapter examines the variety of electoral systems in Europe. Electoral systems lie at the heart of democratic politics, influencing who citizens’ representatives are and having profound effects upon politics at large. The authors start by presenting the variety of electoral systems used across Europe, focusing on three key dimensions: electoral formulas, district magnitudes, and ballot structures. Then they discuss some of the main developments in electoral systems in Europe since 1945, highlighting shifts towards limited proportional systems and more ‘personalized’ systems. Finally, they probe deeper into the consequences of electoral systems, looking at effects on the nature of competition both between and within political parties.
2. Political Parties
Authors: Krouwel André
Published: August 2021

This chapter charts some of the more important developments in European party politics, as well as analysing the contemporary state of party politics. It begins with a discussion of the value of political parties for democracy, after which it describes the origin of party systems in historical social cleavages, how these cleavages relate to the various party families, and the variation in party systems found across European democracies. Subsequently, it examines how parties have changed over time in terms of organization, ideology, and electoral appeal. Highlighting the changing roles political parties performed over time, it focuses on recent changes in European party systems, particularly growing polarization and fragmentation.
14. Security and Terrorism
Authors: Cross Mai’a K. Davis
Published: August 2021

The rise of international terrorism has made domestic security a high-profile issue in Europe. This chapter first provides an overview of the European experience of terrorism, and discusses how European governments have responded to terrorist threats. The focus then shifts to the EU level, as increasingly this is where the most significant developments are taking place in the field of security and counter-terrorism. The chapter delves into the development of the EU’s counter-terrorism policy, within the context of an increasingly stronger European approach to security more generally. Particular attention is paid to the impact of the ISIS-inspired attacks that took place between 2015 and 2017, including the effect they had on national politics.
1. International Relations and Social Science
Authors: Kurki Milja , Wight Colin
Published: August 2021

This chapter focuses on the major debates within International Relations (IR) theory with regard to the philosophy of social science. The philosophy of social science has played a key role in the formation, development, and practice of IR as an academic discipline. Issues concerning the philosophy of social science are frequently described as meta-theoretical debates. Meta-theory primarily deals with the underlying assumptions of all theory and attempts to understand the consequences of such assumptions on the act of theorizing and the practice of empirical research. The chapter first provides an historical overview of the philosophy of social science in IR before discussing both the implicit and explicit roles played by meta-theoretical assumptions in IR. It then considers the contemporary disciplinary debates surrounding the philosophy of social science and concludes by analysing how theoretical approaches to the study of world politics have been shaped by meta-theoretical ideas.
2. Classical Realism
Authors: Lebow Richard Ned
Published: August 2021

This chapter examines the central assumptions of classical realism by analysing the texts of ancient and modern writers and contrasting their ideas with neorealism and other variants of modern realism. Classical realism represents an approach to international relations that dates back to Thucydides and his account of the Peloponnesian War. According to classical realists, power plays a major role in politics, but they also acknowledge its limitations and the ways it can be self-defeating. The chapter begins with a discussion of the position of classical realists regarding order and stability, focusing on the views of Thucydides and Hans J. Morgenthau with respect to the concepts of community, balance of power, and interest and justice. It then considers what classical realists think about change and transformation as well as the nature and purpose of theory. It concludes by commenting on the Iraq war in the context of classical realism.
5. Neoliberalism
Authors: Sterling-Folker Jennifer
Published: August 2021

This chapter examines the neoliberalist argument that international institutions promote international cooperation. While neoliberalism acknowledges that cooperation can be difficult to achieve in anarchic conditions, it insists that institutions allow states to overcome a variety of collective action impediments. The central concern of neoliberal analysis is how institutions do so, and how they might be redesigned to more efficiently obtain cooperative outcomes. This chapter considers three questions that are relevant for understanding neoliberal contributions: How did neoliberalism emerge? What are the barriers to international cooperation? How does neoliberalism study international institutions? The chapter uses the World Trade Organization as a case study to illustrate the importance of institutional design for international free trade cooperation. Along the way, various concepts such as interdependence, hegemonic stability, hegemon, bargaining, defection, compliance, autonomy, and principal–agent theory are discussed, along with the game known as Prisoner’s Dilemma.
17. Still a Discipline After All These Debates?
Authors: Wæver Ole
Published: August 2021

This chapter considers how the arguments associated with the different theories of International Relations discussed in the book sum up. More specifically, it asks whether IR is (still?) a discipline, and whether it is likely to remain one. The chapter examines the intellectual and social patterns of IR and the discipline as a social system, along with its relations of power, privilege, and careers. It also reflects on where, what, and how IR is today by drawing on theories from the sociology of science, whether IR can be regarded as a subdiscipline within political science, and the social structure of IR. It argues that the discipline of international relations is likely to continue whether or not ‘international relations’ remains a distinct or delineable object. It also contends that the core of the intellectual structure in the discipline of IR has been recurring ‘great debates’.
2. Democratic Politics
Authors: De Vries Catherine E. , Hobolt Sara B. , Proksch Sven-Oliver , Slapin Jonathan B.
Published: August 2021

This chapter introduces the proposed theoretical toolbox this book intends to use for the studying of democracy in Europe. The idea is that the analytical concepts created by this toolbox will prove useful for understanding the various aspects of democratic politics seen throughout Europe. The fundamental philosophy of this book is the idea that to understand democratic governance, in particular in Europe, there needs to be a model. The goal isn’t to include every single possible detail of what is observed in the real world. Rather, it is to consider the essential elements for understanding democratic politics and to use those to highlight the various nuances found in the real world. A model is a comparative and analytical tool, rather than a method of example.
11. Law-Making in Governments and Parliaments
Authors: De Vries Catherine E. , Hobolt Sara B. , Proksch Sven-Oliver , Slapin Jonathan B.
Published: August 2021

This chapter explores how political systems across Europe actually make policy and also how they change policy. It examines in detail how coalitions are formed and looks at how coalitions function. The chapter uses the theoretical lens of the Veto Players theory to consider how the nature of governments, and parties within governments, affect the type of policies that become law. It also looks at the ease with which governments can change existing policy. The chapter moves on to address the role of informal actors such as interest groups. Processes differ across different countries and at the European Union (EU) level and that is examined in this chapter as well.
13. Rule of Law and Judicial Politics
Authors: De Vries Catherine E. , Hobolt Sara B. , Proksch Sven-Oliver , Slapin Jonathan B.
Published: August 2021

This chapter examines the importance of law and the rule of law by looking at real-life situations through the lens of theoretical models that consider why people obey the law and how judges interpret the law. The chapter considers when and why citizens and elected officials follow the law. It then moves to the conditions under which this obedience of laws falls. It also explores the importance of courts and judges in interpreting the law, and analyses the interaction of politics and law as a way to try to understand how judges come to their decisions. In particular, it looks at the interaction between national and European Union (EU) law.
Behaviourism
Authors: Herzog Olga
Published: August 2021

This chapter focuses on behaviourism, which is a methodological approach that involves the observable measurement of individual behaviour. It is closely related to the epistemology of positivism and empiricism, which emphasize the observation and verifiability of individual or social phenomena to generate knowledge. Hence, behaviourists focus on the study of perceptible reactions of humans or animals to different situations. Behaviour is understood as reflexive or conscious reactions to different stimuli and does not presume an underlying rationality. Ultimately, behaviourism follows the logic of the natural sciences, by relying on objective, observable information based on sensory experiences. The chapter then traces the origins of behaviourism and its use across disciplines.
Critical Realism
Authors: Giese Dominik , Joseph Jonathan
Published: August 2021

This chapter evaluates critical realism, a term which refers to a philosophy of science connected to the broader approach of scientific realism. In contrast to other philosophies of science, such as positivism and post-positivism, critical realism presents an alternative view on the questions of what is ‘real’ and how one can generate scientific knowledge of the ‘real’. How one answers these questions has implications for how one studies science and society. The critical realist answer starts by prioritizing the ontological question over the epistemological one, by asking: What must the world be like for science to be possible? Critical realism holds the key ontological belief of scientific realism that there is a reality which exists independent of our knowledge and experience of it. Critical realists posit that reality is more complex, and made up of more than the directly observable. More specifically, critical realism understands reality as ‘stratified’ and composed of three ontological domains: the empirical, the actual, and the real. Here lies the basis for causation.
Discourse Analysis
Authors: Narminio Elisa , Carta Caterina
Published: August 2021

This chapter describes discourse analysis. In linguistics, discourse is generally defined as a continuous expression of connected written or spoken language that is larger than a sentence. However, as a method in the social sciences, discourse analysis (DA) gave rise to diatribes about where to set the borders of discourse. As language constitutes the very entry point to the world, some discourse analysts argue that all that exists acquires meaning through language. Does this mean that discourse constitutes reality? Is there anything outside text and discourse? Or is discourse one among many means of social construction? The evolution of DA in social science unearths an ontological debate between ‘realists’ and ‘nominalists’, which eventually reverberates in epistemological strategies.
Ethics in Research
Authors: Marquis Laurence , Daku Mark
Published: August 2021

This chapter studies ethics in research. Ethics play an important role in scientific inquiry, beyond cases of plagiarism, fraud, and misconduct. Importantly, there is a difference between ethical research and ethical researchers. While principles of ethics in research stem mostly from the biomedical field, they have also been adapted to apply to the social sciences. These principles are generally addressed through three common principles: voluntary participation, informed consent, and confidentiality. Researchers themselves must be wary of a number of other factors that can influence their project and role, such as the supervision of students, or other situations where there is a relationship of authority. Similarly, researchers must be careful not to make misrepresentations to subjects about the project or the related risks, or fail to disclose any conflict of interest. Researchers must take steps to ensure their neutrality so that no preconceptions or personal bias can risk influencing the results or subjects. The chapter then looks at ethics review boards and the emergent ethical issues.
Interview Techniques
Authors: Marta Matrakova
Published: August 2021

This chapter explores interview techniques. The use of interviews in social science expanded during the twentieth century. Research interviews with industrial, commercial, and market objectives have also contributed to their development as one of the main methods of social inquiry. The extensive use of interviews as a means of investigation and self-representation in modern society has contributed to their position as the ‘characteristic format for personal narratives’. While positivists conceive interviewers as miners whose main objective is data collection, post-positivists view them as travellers who unravel the intersubjective process of knowledge construction. These different epistemological conceptions of interview research have led to the development of various techniques. The chapter then looks at different types of interviews, including structured/directed interview, semi-structured/semi-directive interview, and in-depth/non-directive interview.
Scope Conditions
Authors: Gauquelin Mathilde
Published: August 2021

This chapter describes scope conditions, the idea of which is rooted in Hempel’s ‘true–false’ paradox of theoretical formulations: one can always find data to support a general theoretical proposition, but conversely, every proposition will also always be subject to contradicting evidence. This realization led scholars to reflect on possible ways to evaluate theories: how can they ever be proven to be valid, if they can never escape falsification? The concept of scope conditions suggests that when formulating general theoretical propositions, scholars may also identify the specific conditions under which they expect these propositions to apply. By doing so, the risk of systematic falsification decreases, and the development of cumulative knowledge becomes possible. The chapter explains the role of scope conditions in theory development and provides guidance on their identification.
Social Network Analysis
Authors: Morin Jean-Frédéric , Olsson Christian , Atikcan Ece Özlem
Published: August 2021

This chapter studies Social Network Analysis (SNA), which is a methods toolbox for analysing the patterning of social ties and explaining how and why those patterns emerge and what consequences they have for social actors. Social networks are ubiquitous in the social world, either unfolding in face-to-face interactions or digitally. In recent decades, SNA has grown in popularity, appealing broadly to students interested in complex social structures. The recent availability of data based on digital traces of social relations (e.g. emails or social media profiles) has further prompted students to study these network structures. Analysing how actors are connected through other actors via paths may indicate how e.g. information or resources flow through the network via these ties.
Statistical Significance
Authors: Morin Jean-Frédéric , Olsson Christian , Atikcan Ece Özlem
Published: August 2021

This chapter highlights statistical significance. The key question in quantitative analysis is whether a pattern observed in a sample also holds for the population from which the sample was drawn. A positive answer to this question implies that the result is ‘statistically significant’ — i.e. it was not produced by a random variation from sample to sample, but, instead, reflects the pattern that exists in the population. The null hypothesis statistical test (NHST) has been a widely used approach for testing whether inference from a sample to the population is valid. Seeking to test whether valid inferences about the population could be made based on the results from a single sample, a researcher should consider a wide variety of approaches and take into the account not only p-values, but also sampling process, sample size, the quality of measurement, and other factors that may influence the reliability of estimates.
Typology
Authors: Morin Jean-Frédéric , Olsson Christian , Atikcan Ece Özlem
Published: August 2021

This chapter assesses typology. The importance of typologies is contested. Some scholars view them as fundamental to concept construction, while others consider that they are temporary devices at best and actually discourage their use. The chapter focuses on the less problematic, heuristic roles of typologies. In this respect, typologies are a proven and widely used instrument for organizing knowledge and ideas at various stages of research, and especially for jump starting the process of generating hypotheses. Moreover, theories are often presented, e.g. for didactic purposes, by means of typologies. Before turning to the uses of typologies, the chapter differentiates between typology, classification, and taxonomy.
Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract
Authors: Zhang Haoyang , Xiu Xuehao , Xue Angli , Yang Yuedong , Yang Yuanhao , Zhao Huiying
Published: August 2021

Background

The epidemiological association between type 2 diabetes and cataract has been well established. However, it remains unclear whether the two diseases share a genetic basis, and if so, whether this reflects a putative causal relationship.

Methods

We used East Asian population-based genome-wide association studies (GWAS) summary statistics of type 2 diabetes (Ncase = 36 614, Ncontrol = 155 150) and cataract (Ncase = 24 622, Ncontrol = 187 831) to comprehensively investigate the shared genetics between the two diseases. We performed: (i) linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (ρ-HESS) to estimate the genetic correlation and local genetic correlation pattern between type 2 diabetes and cataract; (ii) multiple Mendelian randomization (MR) analyses to infer the putative causality between type 2 diabetes and cataract; and (iii) summary-data-based Mendelian randomization (SMR) to identify candidate risk genes underling the putative causality. Moreover, to investigate the extent of the population-specific genetic effect size underlying the shared genetics between type 2 diabetes and cataract, we applied the same analytical pipeline to perform a comparative analysis on European population-based GWAS of type 2 diabetes (Ncase = 62 892, Ncontrol = 596 424) and cataract (Ncase = 5045, Ncontrol = 356 096).

Results

Using East Asian population-based GWAS summary data, we observed a strong genetic correlation [rg = 0.58, 95% confidence interval (CI) = 0.33, 0.83), P-value = 5.60 × 10–6] between type 2 diabetes and cataract. Both ρ-HESS and multiple MR methods consistently showed a putative causal effect of type 2 diabetes on cataract, with estimated liability-scale MR odds ratios (ORs) at around 1.10 (95% CI = 1.06, 1.17). In contrast, no evidence supports a causal effect of cataract on type 2 diabetes. SMR analysis identified two novel genes MIR4453HG (βSMR = −0.34, 95% CI = −0.46, −0.22, P-value = 6.41 × 10–8) and KCNK17 (βSMR = −0.07, 95% CI = −0.09, −0.05, P-value = 2.49 × 10–10), whose expression levels were likely involved in the putative causality of type 2 diabetes on cataract. On the contrary, our comparative analysis on European population provided universally weak evidence on the genetic correlation and causal relationship between the two diseases.

Conclusions

Our results provided robust evidence supporting a putative causal effect of type 2 diabetes on the risk of cataract in East Asians, and revealed potential genetic heterogeneity in the shared genetics underlying type 2 diabetes and cataract between East Asians and Europeans. These findings posed new paths on guiding the prevention and early-stage diagnosis of cataract in type 2 diabetes patients.
The World of Immunization: Achievements, Challenges, and Strategic Vision for the Next Decade
Authors: Lindstrand Ann , Cherian Thomas , Chang-Blanc Diana , Feikin Daniel , O’Brien Katherine L
Published: August 2021

Immunization is among the most cost-effective public health interventions available and is estimated to have averted at least 37 million deaths between 2000 and 2019. Since the establishment of the Expanded Programme on Immunization in 1974, global vaccination coverage increased and the coverage gap between rich and poor countries decreased. Creation of Gavi, the Vaccine Alliance, in 2000 allowed the poorest countries in the world to benefit from new, life-saving vaccines and expand the breadth of protection against an increasing number of vaccine-preventable diseases. Despite this progress, inequities in access to and uptake of vaccines persist. Opportunities to realize the full potential of vaccines are within reach but require focused, tailored and committed action by Governments and immunization stakeholders. The Immunization Agenda 2030 provides a framework for action during the next decade to attain a world where everyone, everywhere, at every age fully benefits from vaccines for good health and well-being.
Functional Antibodies and Innate Immune Responses to WRSS1, a Live Oral Shigella sonnei Vaccine Candidate, in Bangladeshi Adults and Children
Authors: Sarker Protim , Mily Akhirunnesa , Ara Anjuman , Haque Farjana , Maier Nicole , Wierzba Thomas F , Walker Richard I , Venkatesan Malabi M , Raqib Rubhana
Published: August 2021

Background

We demonstrated in a randomized placebo-controlled trial that WRSS1, a live oral Shigella sonnei vaccine candidate, is safe in Bangladeshi adults and children, and elicits antigen-specific antibodies. Here, we describe functional antibody and innate immune responses to WRSS1.

Methods

Adults (18–39 years) and children (5–9 years) received 3 doses of 3 × 105 or 3 × 106 colony forming units (CFU) of WRSS1 or placebo, 4 weeks apart; children additionally received 3 × 104 CFU. Blood and stool were collected at baseline and 7 days after each dose. Functional antibodies were measured using serum bactericidal antibody (SBA) assay. Cytokine/chemokine concentrations were measured in lymphocyte cultures. Host defense peptides LL-37, HBD-1, and HD-5 were analyzed in plasma and stool.

Results

Children showed increased SBA titers over baseline after the third dose of 3 × 106 CFU (P = .048). Significant increases of Th-17 and proinflammatory cytokines (TNF-α, G-CSF, MIP-1β), and reduction of anti-inflammatory and Th2 cytokines (IL-10, IL-13, GM-CSF) were observed in children. Plasma HBD-1 and LL-37 decreased in children after vaccination but were increased/unchanged in adults.

Conclusions

Functional antibodies and Th1/Th17 cytokine responses in children may serve as important indicators of immunogenicity and protective potential of WRSS1.

Clinical Trials Registration: NCT01813071.
FORUM: Stripping Away the Body: Prospects for Reimagining Race in IR
Authors: Harper-Shipman T D , Hall K Melchor Quick , Cutipa-Zorn Gavriel , Dougé-Prosper Mamyrah A
Published: August 2021

It is impossible to talk about race in international relations (IR) without acknowledging the early and groundbreaking intervention of a couple of special issues, followed by conversation-changing book anthologies. Despite these contributions, mainstream IR continues to marginalize the valuable work of non-white institutions and people, while minimizing the role of race and racism in the discipline. In the wake of a historic racial uprising in the United States (and globally) during the summer of 2020, IR scholars returned to critical discussions of race and racism in the contemporary moment.

Although the current conversations on race in IR are crucial for directing the field toward a more generative path, there is still work to be done. Many of the existing formulations of race orient the concept around the somatic. The overreliance on the body as an indication of race can obscure how race as a set of dispossessing structures supported and reproduced through a variety of agents and mechanisms can be discerned through other means. Body-centric conceptualizations of race are also typically divorced from their origins at the root of capitalism, in favor of more US-centric renderings of race as identity. The contributors to this forum think through race as the concomitant othering and rank-ordering of groups that translates into material conditions. We illustrate how race as a material–spatial–temporal relation of power exposes the limits of race as merely phenotype or culture. Through our examination of race in this light, issues of gender effortlessly emerge alongside the study of race. As such, we demonstrate how a re-reading of IR with this formulation of race as its central tenet offers a more generative avenue for explorations of class, gender, security, and power, writ large.
Misalignment between COVID-19 hotspots and clinical trial sites
Authors: Franks Lauren , Liu Hao , Elkind Mitchell S V , Reilly Muredach P , Weng Chunhua , Lee Shing M
Published: August 2021

Hundreds of interventional clinical trials have been launched in the United States to identify effective treatment strategies for combating the coronavirus disease 2019 (COVID-19) pandemic. However, to date, only a small fraction of these trials have completed enrollment, delaying the scientific investigation of COVID-19 and its treatment options. This study presents novel metrics to examine the geographic alignment between COVID-19 hotspots and interventional clinical trial sites and evaluate trial access over time during the evolving pandemic. Using temporal COVID-19 case data from USAFacts.org and trial data from ClinicalTrials.gov, U.S. counties were categorized based on their numbers of cases and trials. Our analysis suggests that alignment and access have worsened as the pandemic shifted over time. We recommend strategies and metrics to evaluate the alignment between cases and trials. Future studies are warranted to investigate the impact of the misalignment of cases and clinical trial sites on clinical trial recruitment.
Surviving an Extensive Burn Injury Using Advanced Skin Replacement Technologies
Authors: Kelly Charis , Wallace David , Moulin Veronique , Germain Lucie , Zuccaro Jennifer , Galdyn Izabela , Fish Joel S
Published: August 2021

There have been significant improvements in the technology available for treating extensive burns in the past decade. This case presents two unique, skin replacement technologies that were used to treat an 86% surface area flame burn in a pediatric patient. A temporary dermal replacement, known as “Novosorb™ Biodegradable Temporizing Matrix” was first used to stabilize the burn injury and remained in place for approximately 3 months. Given the large burn size and lack of available donor skin for grafting, a permanent skin replacement product known as “Self-Assembled Skin Substitute (SASS)” was then utilized to cover the burns. SASS is a novel technology that was developed to replace skin as an autologous skin graft and is currently available in Canada through a clinical trial for major burns. Ultimately, the concurrent use of these two technologies allowed for the unprecedented survival of a child following an extensive and life-threatening burn injury.
Individualized Education Program Team Members’ Perceptions of Music Therapy: An Interpretivist Investigation
Authors: West Rebecca , Furman Amy , Silverman Michael J
Published: August 2021

Although music therapists are often members of the Individualized Education Program (IEP) team in educational settings, there is a lack of research exploring IEP members’ perceptions of music therapy. The purpose of this interpretivist study was to understand the perceptions IEP team members have of music therapy in educational settings; 8 professionals from a single school district who had experience working with music therapists as part of the IEP team participated in an individual semi-structured interview. We used in-vivo coding, an inductive approach to thematic analysis, and member and peer checking. We identified 3 themes: (1) Music Therapy Is Beneficial and Unique, (2) Communication With the Music Therapist is Essential, and (3) Additional Access, Education, and Advocacy Are Needed. These themes were supported by 8 subthemes. Participants identified the relevance and integral role of music therapy in addition to the unique contributions music therapists had as part of the IEP team. Moreover, participants highlighted the importance of communication, continued education for IEP team members, and the need for additional access to music therapy services. Implications for clinical practice, limitations of the study, and suggestions for future research are provided.
Comparative beneficial effects of nebivolol and nebivolol/valsartan combination against mitochondrial dysfunction in angiotensin II-induced pathology in H9c2 cardiomyoblasts
Authors: Gul Rukhsana , Alsalman Nouf , Bazighifan Arwa , Alfadda Assim A
Published: August 2021

Objectives

Considering the complementary nature of signalling mechanisms and the therapeutic effects of nebivolol, a β1-adrenoreceptor antagonist, and valsartan, an angiotensin receptor blocker (ARB), here we aimed to investigate whether nebivolol/valsartan combination would complement the cardioprotective effects of nebivolol on angiotensin II (ANG II)-induced pathology in H9c2 cardiomyoblasts.

Methods

H9c2 cardiomyoblasts were used to investigate the protective effects of nebivolol and nebivolol and valsartan combination against ANG II-induced pathology. Reactive oxygen species (ROS) generation was determined by 2′,7′-dichlorofluorescein diacetate (DCFDA) and MitoSOX Red staining. Real-time PCR and immunoblotting were employed to quantify the changes in mRNA and protein expression levels, respectively.

Key findings

Our data revealed that pretreatment with nebivolol and nebivolol/valsartan combination significantly reduced ANG II-induced oxidative stress and mTORC1 signalling. Concurrently, ANG II-induced activation of inflammatory cytokines and fetal gene expressions were significantly suppressed by nebivolol and nebivolol/valsartan combination. Pretreatment with nebivolol and nebivolol/valsartan combination alleviated ANG II-induced impairment of mitochondrial biogenesis by restoring the gene expression levels of PGC-1α, TFAM, NRF-1 and SIRT3. Our data further show that nebivolol and nebivolol/valsartan combination mediated up-regulation in mitochondrial biogenesis is accompanied by decrease in ANG II-stimulated mitochondrial ROS generation as well as increase in expression of mitochondrial fusion genes MFN2 and OPA1, indicative of improved mitochondrial dynamics.

These findings suggest that both nebivolol and nebivolol/valsartan combination exert protective effects on ANG II-induced mitochondrial dysfunction by alleviating its biogenesis and dynamics. Moreover, addition of valsartan to nebivolol do not produce any additive effects compared with nebivolol alone on ANG II-induced cardiac pathology.
Decision-Making
Authors: Graham Kennedy Ashley
Published: August 2021

The process of diagnostic decision-making (DDM) can be very complex, and in all instances, it involves considerations of epistemology, ethics, probability, and economics. Furthermore, the process of DDM is patient-specific both in terms of qualitative evidence toward a diagnosis (e.g., information from the medical history) and in terms of quantitative evidence (e.g., pre- and post-test probabilities). Thus, learning to make diagnostic decisions requires at least a basic understanding of concepts in each of these fields as well as careful consideration on the part of both the physician and the patient as to how these considerations bear on the individual case at hand. In addition, it requires a commitment on the part of each to shared decision-making in the clinical context.
Avoiding Over- and Underdiagnosis
Authors: Graham Kennedy Ashley
Published: August 2021

This chapter analyzes two examples, one from endocrinology and one from neuroscience, to show that undertreatment and overtreatment are major medical issues that are very much intertwined with the twin diagnostic problems of under- and overdiagnosis. If physicians do not correctly diagnose a disease (or if they miss it altogether), then there is very little hope that they will be able to treat it effectively. On the other hand, if physicians diagnose “disease” that does not cause suffering for the patient, then they might end up causing the patient harm from the subsequent overtreatment of the condition. Therefore, in addition to research on the causal basis of diseases, physicians also need to improve their diagnostic practices by carefully selecting the appropriate screening and/or diagnostic tests and by appealing to clinical findings to aid in interpretation of their results.