bluuebunny/crossref_metadata_2025 huggingface dataset:
First evaluation of stiff-in-soft host–inclusion systems: experimental synthesis of zircon inclusions in quartz crystals
Authors: Gonzalez Joseph P. , Thomas Jay B. , Mazzucchelli Mattia L. , Angel Ross J. , Alvaro Matteo
Published: January 2024

Quartz crystals with zircon inclusions were synthesized using a piston-cylinder apparatus to experimentally evaluate the use of inclusions in “soft” host minerals for elastic thermobarometry. Synthesized zircon inclusion strains and, therefore, pressures (Pinc) were measured using Raman spectroscopy and then compared with the expected inclusion strains and pressures calculated from elastic models. Measured inclusion strains and inclusion pressures are systematically more tensile than the expected values and, thus, re-calculated entrapment pressures are overestimated. These discrepancies are not caused by analytical biases or assumptions in the elastic models and strain calculations. Analysis shows that inclusion strain discrepancies progressively decrease with decreasing experimental temperature in the α-quartz field. This behavior is consistent with inelastic deformation of the host–inclusion pairs induced by the development of large differential stresses during experimental cooling. Therefore, inclusion strains are more reliable for inclusions trapped at lower temperature conditions in the α-quartz field where there is less inelastic deformation of the host–inclusion systems. On the other hand, entrapment isomekes of zircon inclusions entrapped in the β-quartz stability field plot along the α–β quartz phase boundary, suggesting that the inclusion strains were mechanically reset at the phase boundary during experimental cooling and decompression. Therefore, inclusions contained in soft host minerals can be used for elastic thermobarometry and inclusions contained in β-quartz may provide constraints on the P–T at which the host–inclusion system crossed the phase boundary during exhumation.
ChatGPT fails challenging the recent ESCMID brain abscess guideline
Authors: Dyckhoff-Shen Susanne , Koedel Uwe , Brouwer Matthijs C. , Bodilsen Jacob , Klein Matthias
Published: January 2024

Background

With artificial intelligence (AI) on the rise, it remains unclear if AI is able to professionally evaluate medical research and give scientifically valid recommendations.

Aim

This study aimed to assess the accuracy of ChatGPT’s responses to ten key questions on brain abscess diagnostics and treatment in comparison to the guideline recently published by the European Society for Clinical Microbiology and Infectious Diseases (ESCMID).

Methods

All ten PECO (Population, Exposure, Comparator, Outcome) questions which had been developed during the guideline process were presented directly to ChatGPT. Next, ChatGPT was additionally fed with data from studies selected for each PECO question by the ESCMID committee. AI’s responses were subsequently compared with the recommendations of the ESCMID guideline.

Results

For 17 out of 20 challenges, ChatGPT was able to give recommendations on the management of patients with brain abscess, including grade of evidence and strength of recommendation. Without data prompting, 70% of questions were answered very similar to the guideline recommendation. In the answers that differed from the guideline recommendations, no patient hazard was present. Data input slightly improved the clarity of ChatGPT’s recommendations, but, however, led to less correct answers including two recommendations that directly contradicted the guideline, being associated with the possibility of a hazard to the patient.

Conclusion

ChatGPT seems to be able to rapidly gather information on brain abscesses and give recommendations on key questions about their management in most cases. Nevertheless, single responses could possibly harm the patients. Thus, the expertise of an expert committee remains inevitable.
Histamine H2-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II–hypertensive mice
Authors: Assersen Kasper B. , Jensen Boye L. , Enggaard Camilla , Vanhoutte Paul M. , Hansen Pernille B. L.
Published: January 2024

Aldosterone through the mineralocorticoid receptor MR has detrimental effects on cardiovascular disease. It reduces the bioavailability of nitric oxide and impairs endothelium-dependent vasodilatation. In resistance arteries, aldosterone impairs the sensitivity of vascular smooth muscle cells to nitric oxide by promoting the local secretion of histamine which activates H2 receptors. The present experiments tested in vivo and ex vivo the hypothesis that systemic H2-receptor antagonism reduces arterial blood pressure and improves vasodilatation in angiotensin II–induced chronic hypertension. Hypertension was induced by intravenous infusion of angiotensin II (60 ng kg−1 min−1) in conscious, unrestrained mice infused concomitantly with the H2-receptor antagonist ranitidine (27.8 µg kg−1 min−1) or vehicle for 24 days. Heart rate and arterial blood pressure were recorded by indwelling arterial catheter. Resistance (mesenteric) and conductance (aortae) arteries were harvested for perfusion myography and isometric tension recordings by wire myography, respectively. Plasma was analyzed for aldosterone concentration. ANGII infusion resulted in elevated arterial blood pressure and while in vivo treatment with ranitidine reduced plasma aldosterone concentration, it did not reduce blood pressure. Ranitidine improved ex vivo endothelial function (acetylcholine 10−9 to 10−6 mol L−1) in mesenteric resistance arteries. This was abolished by ex vivo treatment with aldosterone (10−9 mol L−1, 1 h). In aortic segments, in vivo ranitidine treatment impaired relaxation. Activation of histamine H2 receptors promotes aldosterone secretion, does not affect arterial blood pressure, and protects endothelial function in conduit arteries but promotes endothelial dysfunction in resistance arteries during angiotensin II–mediated hypertension. Aldosterone contributes little to angiotensin II–induced hypertension in mice.
Long COVID in pediatrics—epidemiology, diagnosis, and management
Authors: Toepfner Nicole , Brinkmann Folke , Augustin Silvia , Stojanov Silvia , Behrends Uta
Published: January 2024

This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID-19 condition (PCC) in children and adolescents. A literature review was performed to synthesize information from clinical studies, expert opinions, and guidelines. PASC also termed Long COVID — at any age comprise a plethora of unspecific symptoms present later than 4 weeks after confirmed or probable infection with severe respiratory syndrome corona virus type 2 (SARS-CoV-2), without another medical explanation. PCC in children and adolescents was defined by the WHO as PASC occurring within 3 months of acute coronavirus disease 2019 (COVID-19), lasting at least 2 months, and limiting daily activities. Pediatric PASC mostly manifest after mild courses of COVID-19 and in the majority of cases remit after few months. However, symptoms can last for more than 1 year and may result in significant disability. Frequent symptoms include fatigue, exertion intolerance, and anxiety. Some patients present with postural tachycardia syndrome (PoTS), and a small number of cases fulfill the clinical criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To date, no diagnostic marker has been established, and differential diagnostics remains challenging. Therapeutic approaches include appropriate self-management as well as the palliation of symptoms by non-pharmaceutical and pharmaceutical strategies.

   Conclusion: PASC in pediatrics present with heterogenous severity and duration. A stepped, interdisciplinary, and individualized approach is essential for appropriate clinical management. Current health care structures have to be adapted, and research was extended to meet the medical and psychosocial needs of young people with PASC or similar conditions.

What is Known:• Post-acute sequelae of coronavirus 2019 (COVID-19) (PASC) — also termed Long COVID — in children and adolescents can lead to activity limitation and reduced quality of life.• PASC belongs to a large group of similar post-acute infection syndromes (PAIS). Specific biomarkers and causal treatment options are not yet available.

What is New:• In February 2023, a case definition for post COVID-19 condition (PCC) in children and adolescents was provided by the World Health Organization (WHO), indicating PASC with duration of at least 2 months and limitation of daily activities. PCC can present as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).• Interdisciplinary collaborations are necessary and have been established worldwide to offer harmonized, multimodal approaches to diagnosis and management of PASC/PCC in children and adolescents.
Efficacy of immunotherapy in HER2-mutated non-small cell lung cancer: a single-arm meta-analysis
Authors: Zhang Juguang , Han Weizhong , Guo Jun , Zhang Chufeng , Cao Lijun , Peng Lixiu , Han Xiao , Wang Zhehai
Published: January 2024

Background

Non-small cell lung cancers (NSCLC) harboring Human Epidermal Growth Factor Receptor 2 (HER2) mutations represent a distinct subset with unique therapeutic challenges. Although immune checkpoint inhibitors (ICIs) have been transformative in lung cancer treatment, the efficacy of ICIs in HER2-mutated NSCLC remains to be established.

Methods

We systematically searched for real-world studies investigating the use of ICIs in treating HER2-mutated NSCLC, sourced from the PubMed, Cochrane Library, and Embase databases. Outcomes including objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS) were extracted for further analysis.

Results

Twelve studies involving 260 patients were enrolled in this meta-analysis. Pooled data revealed an ORR of 0.26 (95% CI 0.17–0.34), a DCR of 0.68 (95% CI 0.55–0.81), and a median PFS (mPFS) of 5.36 months (95% CI 3.50–7.21). Notably, in the subgroup receiving combined immune and chemotherapy, the ORR increased to 0.37 (95% CI 0.26–0.49), the DCR to 0.79 (95% CI 0.70–0.87), and the mPFS to 7.10 months (95% CI 5.21–8.99).

Conclusions

ICIs demonstrate promising anti-tumor activity and safety in patients with HER2-mutated NSCLC. Furthermore, the combined regimen of ICIs and chemotherapy may provide a significant therapeutic option for this patient population.
BAP1, Wilms’ tumor 1, and calretinin in predicting survival and response to first-line chemotherapy in patients with pleural mesothelioma
Authors: Yuce Tuna Han , Ak Guntulu , Metintas Selma , Dundar Emine , Roe Oluf Dimitri , Panou Vasiliki , Metintas Muzaffer
Published: January 2024

Purpose

There are currently no methods to predict response to chemotherapy in pleural mesothelioma (PM). The aim of this study is to investigate the predictive and prognostic role of BAP1, WT1 and calretinin expression and their combinations in pre-treatment tumor samples by immunohistochemical (IHC) staining.

Methods

The study included consecutive PM patients treated with chemotherapy alone at a University hospital between 2009 and 2020. BAP1 analyses were performed on formalin-fixed, paraffin-embedded tumor tissue samples of the patients, while WT1 and calretinin information were obtained from the histopathological diagnosis records.

Results

Of the total 107 patients included, 64% had loss of BAP1 expression, whereas 77% had WT1 and 86% had calretinin expression. Patients with the presence of BAP1 expression, one or both of the other two markers, or loss of expression of all three markers (unfavorable status) were more likely to not respond to chemotherapy than those with the presence of all three markers or loss of BAP1 expression and expression of one or two other markers (favorable status) (p = 0.001). Median survival time of patients with favorable and unfavorable status was 15 ± 1.7 and 8.0 ± 2.4 months, respectively (p = 0.027). After adjustment for histopathology and stage, loss of BAP1 (HR = 0.54, 95%CI 0.35–0.83), WT1 (1.75, 1.06–2.90), calretinin (2.09, 1.14–3.84) expression and favourable panel (0.50, 0.27–0.92) was associated with prognosis.

Conclusions

The IHC biomarkers BAP1, WT1, and calretinin, used in the routine diagnosis of PM and their combinations, are the first biomarkers associated with response to chemotherapy and may be a useful tool to select patients for first-line platinum pemetrexed treatment in PM patients. Validation in a large cohort is ongoing.
Head and neck cancer patient journey’s health literacy: a multidisciplinary team perspective. VOICE study
Authors: Joaquim Ana , Vieira Cláudia , Ribeiro Leonor , Barros Anabela , Leão Inês , Alvim Cecília , Pinheiro Sara , Nogueira Mafalda , Morais Catarina
Published: January 2024

Purpose

Health literacy is a current Public Health priority in Portugal. The participation of well-informed patients in their care and shared decision making are essential, especially in chronic aggressive and debilitating pathologies such as recurrent or metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC).

Aims

This study aimed to characterize R/M HNSCC patients’ and caregivers’ information needs identified by healthcare professionals (HCPs).

Methods

Two online Focus Groups, one with only medical doctors and the other with other HCPs involved in the treatment of R/M HNSCC patients, were conducted, using a modified Metaplan, Lean or adapted PDCA methodology. The discussions were audio recorded in full and content analysis was performed using ATLAS.ti qualitative data analysis software.

Results

Topics addressed were diagnosis, treatment, quality of life, and global evaluation. In general, all experts agreed that only essential information should be cautiously given, according to patients’ and caregivers’ wishes. It was consensual that patients are given the necessary information to adhere to treatment. Two main barriers were identified: one barrier was associated with verbal communication due to the lack of health literacy of these patients, and the other barrier regarded healthcare access. It was also considered important to remind patients of the daily and social activities that they could and should maintain, as well as providing sufficient social resources and problem-solving training to caregivers.

Conclusions

This qualitative study highlights the complexity of R/M HNSCC patients’ care. Immediate availability of psychologists and psychiatrists should be implemented in all centers that treat HNSCC patients. The differences found between the physicians' Focus Group and other HCPs’ Focus Group in some of the addressed topics emphasize the importance of a multidisciplinary and holistic approach, in a biomedical model integrated with a biopsychosocial model.
Determination of a cut-off COmprehensive Score for financial Toxicity (COST) for identifying cost-related treatment nonadherence and impaired health-related quality of life among Chinese patients with cancer
Authors: Xu Binbin , So Winnie K. W. , Choi Kai Chow
Published: January 2024

Purpose

This study aimed to determine a cut-off for the simplified Chinese version of the COmprehensive Score for financial Toxicity (COST) that could identify cost-related treatment nonadherence among Chinese patients with cancer. The study also sought to validate this cut-off score by using it to assess impaired health-related quality of life (HRQoL) in the same population.

Methods

A secondary analysis was conducted using data from a cross-sectional survey of 1208 Chinese patients with cancer who were recruited from 12 hospitals in six cities across three provinces of the Chinese mainland. Sociodemographic information and data on financial toxicity (FT), cost-related treatment nonadherence, and HRQoL were used in the analysis. Receiver operating characteristic (ROC) analysis was used to determine the optimal cut-off for the simplified Chinese version of the COST.

Results

The ROC analysis identified a COST cut-off of 18.5 for identifying cost-related treatment nonadherence, yielding a sensitivity of 76.5% and specificity of 71.4%. In the validation study, this cut-off score yielded a sensitivity of 64.2% and a specificity of 67.1% for identifying impaired HRQoL.

Conclusion

Early and dynamic assessment of cancer-related FT in routine clinical practice may play a crucial role in the early identification and management of FT. Accordingly, a COST cut-off of 18.5 was identified to indicate cost-related treatment nonadherence and impaired HRQoL in a population of patients with cancer from the Chinese mainland. This finding may facilitate the implementation of universal FT screening among patients with cancer in specific settings such as the Chinese mainland.
Malnutrition prevalence in cancer patients in Belgium: The ONCOCARE study
Authors: Rasschaert Marika , Vandecandelaere Pieter , Marechal Stéphanie , D’hondt Randal , Vulsteke Christof , Mailleux Marie , De Roock Wendy , Van Erps Joanna , Himpe Ulrike , De Man Marc , Mertens Geertrui , Ysebaert Dirk
Published: January 2024

Rationale

Unintentional weight loss and malnutrition are common among cancer patients. Malnutrition has been associated with impaired health-related quality of life, less well-tolerated chemotherapy regimens and shorter life duration. In Belgium there is a lack of epidemiological data on malnutrition in oncology patients at advanced stages of the disease.

Methods

Malnutrition assessment data was collected through a prospective, observational study in 328 patients who started a neoadjuvant anticancer therapy regimen or who started 1st, 2nd or 3rd line anticancer therapy for a metastatic cancer via 3 visits according to regular clinical practice (baseline visit (BV) maximum 4 weeks before start therapy, 1st Follow up visit (FUV1) ± 6 weeks after start therapy, FUV2 ± 4 months after start therapy). Malnutrition screening was evaluated using the Nutritional Risk Screening score 2002 (NRS-2002)and the diagnosis of malnutrition by the GLIM criteria. In addition, SARC-F questionnaire and Fearon criteria were used respectively to screen for sarcopenia and cachexia.

Results

Prevalence of malnutrition risk at BV was high: 54.5% of the patients had a NRS ≥ 3 (NRS 2002) and increased during the study period (FUV1: 73.2%, FUV2: 70.1%). Prevalence of malnutrition based on physician subjective assessment (PSA) remained stable over the study period but was much lower compared to NRS results (14.0%—16.5%). At BV, only 10% of the patients got a nutrition plan and 43.9% received ≤ 70% of nutritional needs, percentage increased during FU period (FUV1: 68.4%, FUV2: 67.6%). Prevalence of sarcopenia and cachexia were respectively 12.4% and 38.1% at BV and without significant variation during the study period, but higher than assessed by PSA (11.6% and 6.7% respectively). Figures were also higher compared to PSA. There were modifications in cancer treatment at FUV1 (25.2%) and at FUV2 (50.8%). The main reasons for these modifications at FUV1 were adverse events and tolerability. Patient reported daily questionnaires of food intake showed early nutritional deficits, preceding clinical signs of malnutrition, and therefore can be very useful in the ambulatory setting.

Conclusions

Prevalence of malnutrition and cachexia was high in advanced cancer patients and underestimated by physician assessment. Earlier and rigorous detection of nutritional deficit and adjusted nutritional intake could lead to improved clinical outcomes in cancer patients. Reporting of daily caloric intake by patients was also very helpful with regards to nutritional assessment.
Evaluation of surgical treatment strategies and outcome for cerebral arachnoid cysts in children and adults
Authors: Schmutzer-Sondergeld Michael , Gencer Aylin , Niedermeyer Sebastian , Quach Stefanie , Stoecklein Veit M. , Teske Nico , Schichor Christian , Terpolilli Nicole Angela , Kunz Mathias , Thon Niklas
Published: January 2024

Objective

The best treatment strategies for cerebral arachnoid cysts (CAC) are still up for debate. In this study, we present CAC management, outcome data, and risk factors for recurrence after surgical treatment, focusing on microscopic/endoscopic approaches as compared to minimally invasive stereotactic procedures in children and adults.

Methods

In our single-institution retrospective database, we identified all patients treated surgically for newly diagnosed CAC between 2000 and 2022. Microscopic/endoscopic surgery (ME) aimed for safe cyst wall fenestration. Stereotactic implantation of an internal shunt catheter (STX) to drain CAC into the ventricles and/or cisterns was used as an alternative procedure in patients aged ≥ 3 years. Treatment decisions in favor of ME vs. STX were made by interdisciplinary consensus. The primary study endpoint was time to CAC recurrence (TTR). Secondary endpoints were outcome metrics including clinical symptoms and MR-morphological analyses. Data analysis included subdivision of the total cohort into three distinct age groups (AG1, < 6 years; AG2, 6–18 years; AG3, ≥ 18 years).

Results

Sixty-two patients (median age 26.5 years, range 0–82 years) were analyzed. AG1 included 15, AG2 10, and AG3 37 patients, respectively. The main presenting symptoms were headache and vertigo. In AG1 hygromas, an increase in head circumference and thinning of cranial calvaria were most frequent. Thirty-five patients underwent ME and 27 STX, respectively; frequency did not differ between AGs. There were two (22.2%) periprocedural venous complications in infants (4- and 10-month-old) during an attempt at prepontine fenestration of a complex CAC, one with fatal outcome in a 10-month-old boy. Other complications included postoperative bleeding (2, 22.2%), CSF leaks (4, 44.4%), and meningitis (1, 11.1%). Overall, clinical improvement and significant volume reduction (p = 0.008) were seen in all other patients; this did not differ between AGs. Median follow-up for all patients was 25.4 months (range, 3.1–87.1 months). Recurrent cysts were seen in 16.1%, independent of surgical procedure used (p = 0.7). In cases of recurrence, TTR was 7.9 ± 12.7 months. Preoperative ventricular expansion (p = 0.03), paresis (p = 0.008), and age under 6 years (p = 0.03) were significant risk factors for CAC recurrence in multivariate analysis.

Conclusions

In patients suffering from CAC, both ME and STX can improve clinical symptoms at low procedural risk, with equal extent of CAC volume reduction. However, in infants and young children, CAC are more often associated with severe clinical symptoms, stereotactic procedures have limited use, and microsurgery in the posterior fossa may bear the risk of severe venous bleeding.
Wind energy potential of weather systems affecting South Africa’s Eastern Cape Province
Authors: Landwehr Greg , Lennard Chris , Engelbrecht Francois
Published: January 2024

As a percentage of the total global energy supply, wind energy facilities could provide 10% of the total global energy supply by 2050 as reported in IEA World Energy Outlook (2022). Considering this, a just transition to renewable and sustainable energy in South Africa is a genuine possibility if steps are taken immediately to achieve this. The Eastern Cape Province exhibits a strong wind resource which can be exploited towards expediting such a just energy transition. No research and related modelling have, to date, been undertaken in quantifying and relating the detailed P50 energy yield analyses of representative wind energy facilities in temporal and spatial dimensions to the occurrence of specific synoptic types in South Africa. To quantify this energy meteorology climatology for a suitably sized geospatial area in the Eastern Cape Province of South Africa (spatial focus area, latitude −30 to −35, longitude 20 to 30), the approach of using self-organising maps is proposed. These maps are used to identify the most common synoptic circulation types occurring in the Eastern Cape and can subsequently be mapped onto an equivalent time resolution wind energy production timeseries calculated based on probable wind energy facility sites. This paper describes comprehensive methodologies used to model the wind energy facilities, calculate with high confidence the P50 energy production, and then identify the predominant synoptic weather types responsible for the wind energy production in this spatial focus area. After quantifying the energy production, running a self-organising map software generates a purposely selected 35 node map that characterises archetypal synoptic patterns over the 10-year period. The synoptic types can be ranked by the highest energy production. It is shown that in this spatial area, monthly wind energy production is higher during the winter months. When the well-established high-pressure cells move northward, synoptic types associated with higher energy production are frequent and include tropical and temperate disturbances across South Africa, patterns resembling a ridging anticyclone off the west coast of South Africa and low-pressure cells occurring to the north and south. Low energy producing patterns show characteristics of the high-pressure cells moving southwards producing fine weather and mildly disturbed conditions. The purpose of this methodology is that it provides the foundation required to derive long-term frequency changes of these synoptic weather systems using global climate model ensembles and thus changes in wind energy production.
Sakawa River plume in Sagami Bay, Japan under weak wind condition: numerical simulation of coastal ocean dynamics and in situ observations for validation
Authors: Arai Riwa , Nishi Yoshiki , Fujiwara Yasunori , Zhao Jinrui , Jamil Muhammad Zeeshan
Published: January 2024

This study proposes a method for estimating river plume length from water levels and river discharge rates. A numerical model for coastal ocean dynamics was refined by comparing thermohaline fields calculated using the model with those measured off the mouth of the Sakawa River in Sagami Bay, Japan. The model successfully captured the reduction in salinity within the surface 1.0-m layer caused by riverine water transport. The simulated surface salinity maps revealed that the dynamic motions of the river plumes were primarily driven by one of the two diurnal occurrences of tidal current intensification. Regression analyses of the simulated results demonstrated that the river plume lengths were closely correlated with the water levels and river discharge rates, and that they could be accurately estimated from preceding river discharge rates under weak wind condition.
Exploiting the untapped functional potential of Memento aggregators beyond aggregation
Authors: Kelly Mat
Published: January 2024

Web archives capture, retain, and present historical versions of web pages. Viewing web archives often amounts to a user visiting the Wayback Machine homepage, typing in a URL, then choosing a date and time significant of the capture. Other web archives also capture the web and use Memento as an interoperable point of querying their captures. Memento aggregators are web accessible software packages that allow clients to send requests for past web pages to a single endpoint source that then relays that request to a set of web archives. Though few deployed aggregator instances exist that exhibit this aggregation trait, they all, for the most part, align to a model of serving a request for a URI of an original resource (URI-R) to a client by first querying then aggregating the results of the responses from a collection of web archives. This single tier querying need not be the logical flow of an aggregator, so long as a user can still utilize the aggregator from a single URL. In this paper, we discuss theoretical aggregation models of web archives. We first describe the status quo as the conventional behavior exhibited by an aggregator. We then build on prior work to describe a multi-tiered, structured querying model that may be exhibited by an aggregator. We highlight some potential issues and high-level optimization to ensure efficient aggregation while also extending on the state-of-the-art of memento aggregation. Part of our contribution is the extension of an open-source, user-deployable Memento aggregator to exhibit the capability described in this paper. We also extend a browser extension that typically consults an aggregator to have the ability to aggregate itself rather than needing to consult an external service. A purely client-side, browser-based Memento aggregator is novel to this work.
Adjustability in robust linear optimization
Authors: Wei Ningji , Zhang Peter
Published: January 2024

We investigate the concept of adjustability—the difference in objective values between two types of dynamic robust optimization formulations: one where (static) decisions are made before uncertainty realization, and one where uncertainty is resolved before (adjustable) decisions. This difference reflects the value of information and decision timing in optimization under uncertainty, and is related to several other concepts such as the optimality of decision rules in robust optimization. We develop a theoretical framework to quantify adjustability based on the input data of a robust optimization problem with a linear objective, linear constraints, and fixed recourse. We make very few additional assumptions. In particular, we do not assume constraint-wise separability or parameter nonnegativity that are commonly imposed in the literature for the study of adjustability. This allows us to study important but previously under-investigated problems, such as formulations with equality constraints and problems with both upper and lower bound constraints. Based on the discovery of an interesting connection between the reformulations of the static and fully adjustable problems, our analysis gives a necessary and sufficient condition—in the form of a theorem-of-the-alternatives—for adjustability to be zero when the uncertainty set is polyhedral. Based on this sharp characterization, we provide two efficient mixed-integer optimization formulations to verify zero adjustability. Then, we develop a constructive approach to quantify adjustability when the uncertainty set is general, which results in an efficient and tight poly-time algorithm to bound adjustability. We demonstrate the efficiency and tightness via both theoretical and numerical analyses.
Bone turnover and mineralisation kinetics control trabecular BMDD and apparent bone density: insights from a discrete statistical bone remodelling model
Authors: Castoldi Natalia M. , Pickering Edmund , Sansalone Vittorio , Cooper David , Pivonka Peter
Published: January 2024

The mechanical quality of trabecular bone is influenced by its mineral content and spatial distribution, which is controlled by bone remodelling and mineralisation. Mineralisation kinetics occur in two phases: a fast primary mineralisation and a secondary mineralisation that can last from several months to years. Variations in bone turnover and mineralisation kinetics can be observed in the bone mineral density distribution (BMDD). Here, we propose a statistical spatio-temporal bone remodelling model to study the effects of bone turnover (associated with the activation frequency $$\mathrm {Ac.f}$$

Ac
.
f

) and mineralisation kinetics (associated with secondary mineralisation $$T_\textrm{sec}$$

T
sec

) on BMDD. In this model, individual basic multicellular units (BMUs) are activated discretely on trabecular surfaces that undergo typical bone remodelling periods. Our results highlight that trabecular BMDD is strongly regulated by $$\mathrm {Ac.f}$$

Ac
.
f

and $$T_\textrm{sec}$$

T
sec

in a coupled way. Ca wt% increases with lower $$\mathrm {Ac.f}$$

Ac
.
f

and short $$T_\textrm{sec}$$

T
sec

. For example, a $$\mathrm {Ac.f}=$$

Ac
.
f

=

4 BMU/year/mm$$^3$$

3

and $$T_\textrm{sec}$$

T
sec

= 8 years result in a mean Ca wt% of 25, which is in accordance with Ca wt% values reported in quantitative backscattered electron imaging (qBEI) experiments. However, for lower $$\mathrm {Ac.f}$$

Ac
.
f

and shorter $$T_\textrm{sec}$$

T
sec

(from 0.5 to 4 years) one obtains a high Ca wt% and a very narrow skew BMDD to the right. This close link between $$\mathrm {Ac.f}$$

Ac
.
f

and $$T_\textrm{sec}$$

T
sec

highlights the importance of considering both characteristics to draw meaningful conclusion about bone quality. Overall, this model represents a new approach to modelling healthy and diseased bone and can aid in developing deeper insights into disease states like osteoporosis.
An inflammatory response-related gene signature can predict the prognosis and impact the immune infiltration of multiple myeloma
Authors: Zhao Qian , Li Feng , Li Jing , Xia Yuan , Wang Jing , Chen Lijuan
Published: January 2024

Multiple myeloma (MM) is a highly heterogeneous and incurable disease. Inflammation plays a vital role in cancer genesis and progression. However, the relationship between inflammatory response-related genes (IRRGs) and the prognosis of MM patients remains unknown. We constructed a IRRGs prognosis model by least absolute shrinkage and selection operator regression analysis. Moreover, clinical multivariate regression was performed to identify clinical implications. Gene set enrichment analysis was implemented to conduct its biological properties. CIBERSORT deconvolution algorithm was utilized to calculate the immune cell infiltration in different risk groups. The flow cytometry was utilized to perform protein expression of prognostic gene. A Six-IRRGs (VCAM1, RGS1, KIT, CD81, BLNK, and BIRC3) prognostic risk model was successfully constructed and validated. The risk model was an independent predictor for overall survival. Enrichment analysis revealed autophagy and PI3K–Akt signaling pathways were enriched in the high-risk group. Furthermore, we found CD81 widely impacted on the infiltration of immune cells, especially on monocytes and macrophages2. At last, the role of CD81 in MM was confirmed to be an adverse prognostic factor in clinical. Our study explores the potential application value of IRRGs in MM. These findings may provide new insights into the treatment for MM patients.
FLI-1 is expressed in a wide variety of hematolymphoid neoplasms: a special concern in the differential diagnosis
Authors: Cho Uiju , Cha Hee Jeong , Kim Hyun Jung , Min Soo Kee , Kim Hee Kyung , Jung Hye Ra , Park Gyeongsin , Kim Ji Eun
Published: January 2024

Friend Leukemia Virus Integration 1 (FLI-1) is a member of E26 transformation-specific family of transcription factors that participates in hematopoietic and vascular endothelial cell development. Immunohistochemical detection of FLI-1 has been widely used to diagnose vascular tumors or, more evidently, Ewing’s sarcoma. However, the expression pattern of FLI-1 in hematolymphoid neoplasms remains unclear. Therefore, in this study, we aimed to investigate the expression of FLI-1 in these tumors, focusing on high-grade lesions, which presents a diagnostic challenge by mimicking Ewing’s sarcoma. We evaluated the expression FLI-1 in various types of lymphoid and plasmacytic tumors, including 27 plasmablastic lymphomas, 229 diffuse large B-cell lymphomas, 22 precursor T- or B-lymphoblastic lymphomas, 24 angioimmunoblastic-type nodal T-follicular helper cell lymphomas, 52 peripheral T-cell lymphomas, NOS, 18 Burkitt lymphomas, 18 non-gastric lymphomas of mucosa-associated lymphoid tissue, 38 chronic lymphocytic leukemia/small lymphocytic lymphomas, 15 mantle cell lymphomas, 23 gastric MALT lymphomas, 50 plasma cell myelomas, and 38 follicular lymphomas. We calculated the H-scores of FLI-1 immunostaining, ranging from 0 to 200, and used the scores to analyze the clinicopathological significance of FLI-1 statistically. FLI-1 was expressed to varying degrees in all types of hematological tumors. FLI-1 expression was detected in 84.1% of patients (466/554). FLI-1 was highly expressed in precursor T- or B-lymphoblastic lymphomas. Follicular lymphomas exhibited low FLI-1 expression. In plasmablastic lymphoma, 85.2% of the patients were focally positive for FLI-1. FLI-1 expression did not correlate with clinicopathological variables, such as demographic data or disease stage, in patients with plasmablastic lymphoma and diffuse large B-cell lymphoma. However, FLI-1 overexpression was associated with poorer overall survival in patients with plasmablastic lymphoma. This study demonstrates that FLI-1 is expressed in various hematolymphoid neoplasms. FLI-1 expression can lead to diagnostic confusion, especially in small blue round cell tumors, such as lymphoblastic lymphoma, plasmablastic lymphoma, and plasma cell myeloma, when distinguishing tumors positive for CD99 and CD56 without CD3, CD20, or CD45. Our findings also suggested the possibility of FLI-1 as a potential prognostic biomarker for plasmablastic lymphoma.
The relationship between peripheral T follicular helper cells and disease severity in systemic sclerosis
Authors: Sahinoglu Melek , Sargin Gokhan , Yavasoglu Irfan , Senturk Taskin
Published: January 2024

We aimed to investigate the association between follicular T helper cells (Tfh) and disease severity in systemic sclerosis (SSc), a chronic connective tissue disease characterized by progressive fibrosis. While Tfh cells have been extensively studied in other autoimmune diseases, their role in SSc remains poorly understood. A cohort of 50 SSc patients, diagnosed based on the ACR/EULAR 2013 classification criteria, was included in the study. Patient data, including demographic information, comorbidities, treatment history and organ involvement, were collected. Disease severity was assessed using the modified Rodnan skin score and Medsger disease severity index. Statistical analyses were performed, considering a p value of < 0.05 as statistically significant. 38% had SSc with limited skin involvement, while 62% had SSc with extensive skin involvement. However, there were no statistically significant differences observed in the levels of CD4+ CXCR5+ , CD4+ ICOS+ , CD4+ CD40L+ and CD4+ PD+ lymphocytes between the two groups. Notably, SSc patients with Raynaud’s phenomenon, digital ulcer and lung involvement exhibited higher levels of CD4+ CXCR5+ lymphocytes compared to those without these manifestations. Furthermore, a significant positive correlation was observed between CD4+ CXCR5+ lymphocyte levels and the severity of lung disease according to the Medsger disease severity index. Based on these findings, we conclude that elevated levels of Tfh cells are associated with lung involvement in SSc and there is a significant correlation between Tfh cell levels and the severity of lung disease. These observations suggest a potential role for Tfh cells in the pathogenesis of lung involvement in SSc and may guide the development of targeted therapies for this aspect of the disease.
Monitoring urban biological invasions using citizen science: the polyphagous shot hole borer (Euwallacea fornicatus)
Authors: Potgieter Luke J. , Cadotte Marc W. , Roets Francois , Richardson David M.
Published: January 2024

Benefits provided by urban trees are increasingly threatened by non-native pests and pathogens. Monitoring of these invasions is critical for the effective management and conservation of urban tree populations. However, a shortage of professionally collected species occurrence data is a major impediment to assessments of biological invasions in urban areas. We applied data from iNaturalist to develop a protocol for monitoring urban biological invasions using the polyphagous shot hole borer (PSHB) invasion in two urban areas of South Africa. iNaturalist records for all known PSHB reproductive host species were used together with data on localities of sites for processing plant biomass to map priority monitoring areas for detecting new and expanding PSHB infestations. Priority monitoring areas were also identified using the distribution of Acer negundo, a highly susceptible host that serves as a sentinel species for the detection of PSHB infestations. iNaturalist data provided close to 9000 observations for hosts in which PSHB is known to reproduce in our study area (349 of which were A. negundo). High-priority areas for PSHB monitoring include those with the highest density of PSHB reproductive hosts found close to the 140 plant biomass sites identified. We also identified high-priority roads for visual and baited trap surveys, providing operational guidance for practitioners. The monitoring protocol developed in this study highlights the value of citizen or community science data in informing the management of urban biological invasions. It also advocates for the use of platforms such as iNaturalist as essential tools for conservation monitoring in urban landscapes.
Ensemble-based history matching of the Edvard Grieg field using 4D seismic data
Authors: Lorentzen Rolf J. , Bhakta Tuhin , Fossum Kristian , Haugen Jon André , Lie Espen Oen , Ndingwan Abel Onana , Straith Knut Richard
Published: January 2024

The Edvard Grieg field is a highly complex and heterogeneous reservoir with an extensive fault structure and a mixture of sandstone, conglomerate, and shale. In this paper, we present a complete workflow for history matching the Edvard Grieg field using an ensemble smoother for Bayesian inference. An important aspect of the workflow is a methodology to check that the prior assumptions are suitable for assimilating the data, and procedures to verify that the posterior results are plausible and credible. We thoroughly describe several tools and visualization techniques for these purposes. Using these methods we show how to identify important parameters of the model. Furthermore, we utilize new compression methods for better handling large datasets. Simulating fluid flow and seismic response for reservoirs of this size and complexity requires high numerical resolution and accurate seismic models. We present a novel dual-model concept for a better representation of seismic data and attributes, that deploy different models for the underground depending on simulated properties. Results from history matching show that we can improve data matches for both production data and different seismic attributes. Updated parameters give new insight into the reservoir dynamics, and are calibrated to better represent water movement and pressure.
Existential Social Work in Coping with Death and Grief
Authors: Temiz Rıdvan
Published: January 2024

This article delves into the use of existential social work in coping with death and grief. After defining death and grief, the article explores individuals' attitudes towards death and the theoretical perspectives related to death and grief. The article further examines the fundamental concept of existentialism within the context of coping with death and grief. The article then considers the theoretical basis of an existentialist approach to social work evaluation and intervention. It highlights the importance of an existentialist approach in the process of coping with death and grief, as it encourages individuals to confront the reality of death and find meaning in life. Ultimately, the article contributes to the field of social work by providing insights into the theoretical foundations of existential social work in the context of death and grief. In order to enhance understanding, this article includes a case example, contributing to a deeper understanding of the practical application of existential social work in dealing with death and grief.
Regulatory Stringency and Emission Leakage Mitigation
Authors: Antoniou Fabio , Hatzipanayotou Panos , Tsakiris Nikos
Published: January 2024

We construct a two-country trade model where emissions are an input in production and generate cross-border pollution. We examine the strategic incentives of an active regulator who sets a binding level of emissions in production. We show that, in the presence of terms of trade and emission leakage strategic motives, tighter regulation can mitigate emission leakage, reduce global pollution, and improve a country’s welfare. This result and the corresponding policy implications depend on the relative magnitude of emissions intensities of goods between sectors and on their relationship in production and consumption.
Covariational reasoning in Bayesian situations
Authors: Büchter Theresa , Eichler Andreas , Böcherer-Linder Katharina , Vogel Markus , Binder Karin , Krauss Stefan , Steib Nicole
Published: January 2024

Previous studies on Bayesian situations, in which probabilistic information is used to update the probability of a hypothesis, have often focused on the calculation of a posterior probability. We argue that for an in-depth understanding of Bayesian situations, it is (apart from mere calculation) also necessary to be able to evaluate the effect of changes of parameters in the Bayesian situation and the consequences, e.g., for the posterior probability. Thus, by understanding Bayes’ formula as a function, the concept of covariation is introduced as an extension of conventional Bayesian reasoning, and covariational reasoning in Bayesian situations is studied. Prospective teachers (N=173) for primary (N=112) and secondary (N=61) school from two German universities participated in the study and reasoned about covariation in Bayesian situations. In a mixed-methods approach, firstly, the elaborateness of prospective teachers’ covariational reasoning is assessed by analysing the arguments qualitatively, using an adaption of the Structure of Observed Learning Outcome (SOLO) taxonomy. Secondly, the influence of possibly supportive variables on covariational reasoning is analysed quantitatively by checking whether (i) the changed parameter in the Bayesian situation (false-positive rate, true-positive rate or base rate), (ii) the visualisation depicting the Bayesian situation (double-tree vs. unit square) or (iii) the calculation (correct or incorrect) influences the SOLO level. The results show that among these three variables, only the changed parameter seems to influence the covariational reasoning. Implications are discussed.
Homotopy equivalent boundaries of cube complexes
Authors: Fernós Talia , Futer David , Hagen Mark
Published: January 2024

A finite-dimensional CAT(0) cube complex X is equipped with several well-studied boundaries. These include the Tits boundary$$\partial _TX$$

∂
T

X

(which depends on the CAT(0) metric), the Roller boundary$${\partial _R}X$$

∂
R

X

(which depends only on the combinatorial structure), and the simplicial boundary$$\partial _\triangle X$$

∂
▵

X

(which also depends only on the combinatorial structure). We use a partial order on a certain quotient of $${\partial _R}X$$

∂
R

X

to define a simplicial Roller boundary $${\mathfrak {R}}_\triangle X$$

R
▵

X

. Then, we show that $$\partial _TX$$

∂
T

X

, $$\partial _\triangle X$$

∂
▵

X

, and $${\mathfrak {R}}_\triangle X$$

R
▵

X

are all homotopy equivalent, $$\text {Aut}(X)$$

Aut
(
X
)

-equivariantly up to homotopy. As an application, we deduce that the perturbations of the CAT(0) metric introduced by Qing do not affect the equivariant homotopy type of the Tits boundary. Along the way, we develop a self-contained exposition providing a dictionary among different perspectives on cube complexes.