bluuebunny/crossref_metadata_2025 huggingface dataset:
El lugar de lo imaginable en la concepción de imagen divina según Juan Damasceno
Authors: Méndez Gallardo Brenda Mariana
Published: April 2023

El hombre, al ser definido como compuesto y doble, estaría relacionado tanto con el ámbito espiritual como con el material. Según esto, Juan Damasceno inferiría que, por tanto, el conocimiento humano necesariamente sería un reflejo de ambos ámbitos.
Las «humanidades» en El conflicto de las facultades de Immanuel Kant
Authors: Parra París Lisímaco
Published: April 2023

Voy a formular más o menos abruptamente mi tesis central. Pienso que la función de las humanidades que puede derivarse de El conflicto de las facultades consiste en construir una legitimación de la dominación. Rousseau, quien en muchos aspectos bien podría considerarse como un kantiano avant la lettre, ha formulado esta tarea en los siguientes términos: «El más fuerte nunca es lo suficientemente fuerte para ser siempre el amo, si no transforma su fuerza en derecho y la obediencia en deber» (Rousseau, [1762] 1963, p. 53). Soy consciente de que asignar a las humanidades tales transformaciones resultará extraño. Estamos acostumbrados a definiciones más «humanísticas» de las humanidades. Con todo, eso es lo que yo infiero del texto kantiano. Superada la extrañeza inicial y dejando de lado inevitables anacronismos, creo que la lectura de los ensayos kantianos nos puede sorprender por la persistencia de su vigor. La crisis actual y más o menos global de la política reside, justamente, en la inoperancia, cuando no en la ausencia, de discursos legitimadores: claramente, el elogio de la eficiencia resulta insuficiente. Y cuando solo disponemos de él, parecería que estamos ad portas de la barbarie.
Las trampas de la filosofía
Authors: Dávila Morey Dante
Published: April 2023

Desde su origen, la filosofía ha sido un saber cuestionado, una actividad de la que habría que sospechar y desconfiar con razón. En diversas épocas y de diversas maneras, las ciencias le han discutido su rigor metódico y su consistencia epistemológica; los saberes prácticos le han criticado su falta de utilidad y de relevancia social; la religión ha cuestionado lo limitado de su búsqueda y el alcance de sus afirmaciones; y el sentido común la ha considerado como una actividad que se complica innecesariamente sobre la explicación del sentido de las cosas. Así, como parte de su actividad especulativa, la filosofía se ha acostumbrado a luchar argumentativamente en cada época por afirmar su saber, por hacer frente a los ataques que en determinados momentos se han hecho virulentos y por darse un lugar en el conjunto del conocimiento. Pero, aparte de estos adversarios externos y de actitudes de saberes ajenos a la filosofía, muchos de ellos antiguos y otros de épocas recientes, hay algunos adversarios internos que actúan como trampas inmanentes al quehacer filosófico. Si una trampa es un dispositivo para atrapar, burlar o perjudicar a alguien, estas trampas han surgido en el desenvolvimiento normal de la actividad filosófica, y a veces las tenemos tan enraizadas que ni siquiera podemos darnos cuenta de cómo ni en qué momento hemos caído en sus artificios. Ellas actúan como las aporías de las que nos habla Aristóteles en el libro III de la Metafísica. Pero, mientras las aporías son dificultades que surgen del carácter problemático de la realidad, es decir, de la naturaleza propia de la cosa misma tal como se le presenta al espíritu atento, estas trampas surgen de un acercamiento unilateral a las dificultades o de cierta imprecisión en el planteamiento de los problemas.
El ideal de humanidad y las humanidades : dialogando con Kant, Fichte y Husserl
Authors: Rizo-Patrón de Lerner Rosemary
Published: April 2023

No hay que esperar a la aparición de las universidades europeas en el siglo XIII, o al giro radical que parece introducirse en el rumbo de la historia europea desde la llamada Ilustración en la Edad Moderna, para constatar la difícil relación que el filósofo siempre ha mantenido —como señala Merleau-Ponty— «con los dioses de la Ciudad, es decir, con los otros hombres y con lo absoluto fijado, cuya imagen ellos le tienden» (2006, p. 25). En El elogio de la filosofía, de 1953, Merleau-Ponty señala —refiriéndose a la vida y la muerte de Sócrates— que no sería tanto un problema «si el filósofo fuese un rebelde»; pues, «la rebelión», en tanto tal, «no desagrada». Por el contrario, Sócrates ofrece sacrificios a los dioses, señala que su religión es verdadera y conmina a los ciudadanos a «obedecer a la Ciudad».
La ingeniería y las humanidades en la universidad
Authors: Blondet Marcial
Published: April 2023

El antiguo «conflicto entre facultades» volvió a ponerse en relevancia el siglo pasado, luego de la publicación del libro The Two Cultures, en el que C.P. Snow sostiene lo siguiente: [...] la vida intelectual de toda la sociedad occidental se está viendo dividida cada vez más en dos grupos polarizados: [...] en un polo tenemos a los intelectuales literarios [...] [en el otro polo] a los científicos. [...] Entre los dos, una brecha de mutua incomprensión [1959, p. 3]. Esta separación entre las culturas científicas y humanísticas sigue viva en nuestros días. Ella ha sido reconocida como un problema, un obstáculo para la formación integral de los estudiantes —formación que necesariamente implica componentes científicos y humanísticos— y para la investigación de los problemas importantes actuales, los cuales son complejos y multidimensionales y que, por tanto, requieren de un enfoque interdisciplinario.
La aparición de la historia como disciplina académica en el Perú del siglo XIX : discusiones y contexto
Authors: de la Puente Brunke José
Published: April 2023

La figura del historiador formado en las aulas universitarias como tal y dedicado profesionalmente a la disciplina por medio de la docencia o la investigación —es decir, sosteniéndose económicamente de modo exclusivo de su trabajo como historiador— es un fenómeno que aparece en el Perú no antes de la década de 1960. Sin embargo, el proceso en virtud del cual la historia se fue convirtiendo en una disciplina académica en el Perú se remonta al siglo XIX. Así, este trabajo pretende aproximarse a ese proceso: se referirá a algunos de los principales estudiosos del pasado de nuestro país en esa centuria, a sus motivaciones y a los movimientos intelectuales y políticos en cuyo marco desarrollaron sus trabajos, como el Romanticismo y el nacionalismo. Si bien dichos personajes pueden ser considerados hoy, en buena medida, historiadores «aficionados» —a pesar de que varios de ellos se interesaron en las cuestiones metodológicas—, los acontecimientos y los temas que estudiaron siguen considerándose en la actualidad fundamentales en nuestras visiones de la historia del Perú.
Estudios visuales versus historia del arte : la alternativa interdisciplinaria
Authors: Fernández Eva Natalia
Published: April 2023

En este ensayo se intentarán describir algunos aspectos de (1) la historia del arte y (2) los estudios visuales, estableciendo algunas diferencias que podrían sugerir que la historia del arte se ha quedado rezagada debido a su encasillamiento disciplinario, mientras que los estudios visuales expanden su campo, traspasan los límites, convirtiéndose en estudios de carácter interdisciplinar. En un tercer apartado concluyente, se sostiene que la interdisciplinariedad es una salida fehaciente a la crisis que atraviesan algunos departamentos en las universidades en la actualidad, dado que permite el trabajo de una comunidad académica que busca incidir en la realidad compleja.
La importancia de las humanidades en la formación de un científico
Authors: Gago A.M.
Published: April 2023

En este artículo vamos a comentar los beneficios que se siguen tanto de que las humanidades sean parte de la formación de un científico como viceversa. Dentro de este marco de discusión, es importante tener en cuenta que la formación de un científico requiere de un alto grado de especialización. Por ejemplo, la física se subdivide en una serie de áreas como: la óptica cuántica, la ciencia de los materiales, las partículas elementales, entre otras. Dichas áreas casi pueden ser consideradas especialidades distintas. Sin embargo, a pesar de esta necesidad de especialización, no deben ser excluidos los cursos de humanidades, debido a que juegan un rol indispensable en el proceso de formación de un científico.
Humanidades, ciencias y el proyecto de unificación del conocimiento
Authors: Rodríguez-Mondoñedo Miguel
Published: April 2023

En este breve trabajo pretendo desarrollar el siguiente argumento: las humanidades y las ciencias no tienen por qué seguir funcionando como si se tratara de planetas donde los habitantes de uno no pudieran sobrevivir en el otro. Así como el mundo es uno, así tendría que ser también el conocimiento. No resulta sorprendente que esta consideración ofrezca ventajas adicionales para resolver el conflicto de las facultades y sus herederos contemporáneos.
Del homo academicus al homo oeconomicus
Authors: Cortés Rodas Francisco
Published: April 2023

En nuestras sociedades hay una serie de limitaciones estructurales que impiden tener en la educación secundaria y universitaria una juventud con una visión crítica, sensible a los problemas sociales y solidaria con los más necesitados. Esta limitación se refleja en la situación que experimentamos en el mundo social: vivimos en un mundo habitado por expertos, especializados en una variedad de saberes, y por personas sin educación, ignorantes, sin cultura, sin mundo. Los primeros se han distanciado del mundo público y de los problemas políticos de sus sociedades y han delegado estos asuntos a expertos en política, administración o gobernanza. Los segundos, carentes de educación, son incapaces de distinguir lo auténtico y noble de la cultura de «las oleadas de basura efímera, superstición, irracionalismo y explotación comercial que nos ofrece el capitalismo» (Steiner, 2008, p. 154). En este momento de la historia de la sociedad capitalista, las universidades, los colegios, los medios de comunicación, los ciudadanos han abandonado en una medida preocupante el programa de una educación humanista y liberal. El neoliberalismo ha creado una situación espiritual en la que el individuo autónomo, que piensa por sí mismo, ha sido lentamente sustituido por un sujeto formado en el disfrute desenfrenado del consumo y enaltecido como un «yo» libre por la sociedad del espectáculo. El individuo de la sociedad neoliberal, el trabajador y consumidor que solamente se preocupa por sus intereses privados, carece de una educación ciudadana y se distancia totalmente de lo público. A él le interesa la autoinversión en formas que contribuyan a su apreciación. Esto incluye dar un valor a aportes como la educación; prever y ajustarse a los cambiantes mercados de vivienda, salud y retiro, en modos que aumenten su valor. El hombre de la sociedad neoliberal es el sujeto competitivo, que «busca el modo de maximizar su capital humano en todos los dominios, [...] que persigue, sobre todo, trabajar sobre sí mismo con el fin de transformarse permanentemente, de mejorar, de volverse cada vez más eficaz» (Laval y Dardot, 2013, pos. 7539;1 para hacer esta caracterización del neoliberalismo, me baso en las tesis de Brown, 2015; Wallerstein y otros, 2013; Streeck, 2016 y Laval y Dardot, 2013)
El pensamiento humanista como ruta hacia el valor de la humanidad
Authors: Crary Alice Marguerite
Published: April 2023

El presente artículo es una defensa de la posición según la cual la humanidad —ser humano— es en sí misma un valor moral y político. Los valores exigen ser defendidos cuando se encuentran bajo ataque. Un aspecto llamativo del clima intelectual de nuestros tiempos es el brote de un escepticismo con respecto a la importancia de lo que significa ser simplemente humano. Dicho escepticismo moldea muchas discusiones orientadas por el posestructuralismo en torno al «poshumanismo». También cumple una función estructural en muchas conversaciones dentro de los estudios animales —conversaciones en las que se asume que comprometerse con la afirmación del valor de las vidas de los animales supone rechazar la idea de la importancia humana, importancia que estaría derivada de una forma de «especismo»—. Esta tendencia escéptica se muestra de manera particularmente problemática en los debates filosóficos acerca del estatus moral. En este campo, la hostilidad ante la posición de que el mero hecho de ser un ser humano importa es utilizada para sancionar la indignante sugerencia de que los seres humanos con discapacidades cognitivas merecerían, por ello, menos atención y respeto. En este ensayo, tomo a las disputas acerca del estatus moral como un punto de partida para defender el valor de la humanidad. Mi tesis es que la mencionada antipatía frente a dicho valor es, en buena parte, resultado de una desconfianza en los métodos moralmente no neutrales que caracterizan a las disciplinas humanistas. Quisiera sugerir que, si hemos de reconocer la importancia moral y política del mero hecho de ser humanos, debemos tomar en serio el poder cognitivo de dichos métodos.
Apuntes de Geotecnia Aplicada
Authors: Ramírez Óscar
Published: April 2023

Este libro está basado en la recopilación de temas relacionados con la Asignatura Geotecnia Aplicada 1 de la UPTC, elaborado con la revisión bibliográfica de diferentes autores, en el que se mencionan elementos como, la exploración del subsuelo, basado en los requerimientos normativos vigentes, seguido de un capítulo denominado Cimentaciones, en el que se hace énfasis en la determinación fundamentado en la capacidad portante de un suelo ante cimentaciones superficiales, exponiendo los diferentes modelos matemáticos para su determinación; posteriormente, se entregan los capítulos referentes a las deformaciones en los suelos, en los que se estudian las diferentes metodologías empleadas en Ingeniería Civil para su determinación; por último, el lector encontrará con temas relacionados con Diseño de cimentaciones, en donde se expresan las características necesarias para que el estudiante comprenda los requerimientos mínimos de un diseño geotécnico de cimentaciones superficiales.
JADWIGA KOCZOCIK-PRZEDPELSKA (1920–2023) – MEMORIES
Authors: Huber Juliusz
Published: April 2023

The article presents memories of Jadwiga Koczocik (1920–2023), an eminent scientist, physician and patriot, originator of clinical neurophysiology in Poznań, Poland
PSEUDOPARALYSIS
Authors: Neyton Lionel
Published: April 2023

The definition of pseudoparalysis in shoulder is controversial. Gwschend initially described pseudoparalysis as an appearance of paralysis with severe rotator cuff tear. Later, Werner described pseudoparesis as active elevation under 90° caused by an irreparable massive cuff tear. Since these descriptions, many articles across the literature make the confusion between pseudoparesis and pseudoparalysis who differ in term of lesion and treatment options. Subsequently, this adds confusion to confusion when evaluating the results to determine the optimal therapeutic strategy. Conservative and arthroplasty options are discussed but the reverse arthroplasty appears to be the treatment of choice in a true pseudoparalyzed shoulder.
Emisión de gases de efecto invernadero en la economía mexicana y políticas de mitigación, 2020-2030
Authors: Ruiz Nápoles Pablo , Castañeda León Javier , Reyes Eduardo Moreno
Published: April 2023

En este trabajo desarrollamos un modelo de insumo-producto medioambiental para la economía mexicana con el fin de explorar qué tanto es posible reducir la emisión de gases de efecto invernadero (GEI) en la economía para 2030. El modelo muestra cómo nuevas tecnologías aplicadas en subsectores seleccionados de la economía reducen las emisiones totales y estima los impactos de tales tecnologías en las emisiones anuales de gei hasta 2030. Utilizamos esta metodología con el propósito de estimar dos trayectorias: una a la que llamamos “base” y otra que resulta de simular un cambio tecnológico en las ramas seleccionadas. A partir de los resultados, concluimos que el cambio tecnológico, aun limitado a unas cuantas ramas, tiende a producir efectos benéficos importantes en materia de reducción de GEI.
El debate sobre la organización de la política económica en un mundo dominado por la finanza: implicaciones para México
Authors: Capraro Santiago , Panico Carlo , Torres Gonzalez Luis Daniel
Published: April 2023

El trabajo muestra que los procesos de liberalización y la expansión del sector financiero han cambiado profundamente la vida económica, social y política de la economía mundial. Han surgido fenómenos nuevos, por ejemplo, la supremacía de las autoridades monetarias sobre las fiscales y la transformación de los gobiernos nacionales en acreedores de los bancos centrales. Estos cambios han generado consecuencias negativas, como la inestabilidad financiera, el aumento del número de crisis, el bajo crecimiento y la desigualdad distributiva. El artículo aclara la necesidad de modificar aspectos relevantes de la política económica. Se argumenta que atribuir a las autoridades monetarias el papel de líderes en la coordinación de las políticas económicas perjudica el crecimiento y la equidad distributiva. Se alega que debe devolverse discrecionalidad a la política fiscal y que la intervención pública tiene que guiar la evolución de la estructura productiva. A fin de cumplir lo primero, deben mejorarse la calidad de las políticas públicas y los niveles de confianza entre las diferentes instituciones de la política económica nacional y entre los operadores de los mercados financieros y las autoridades de gobierno.
The Influence of Urbanization, Foreign Direct Investment, and Economic Growth on Environmental Degradation in the OIC Countries
Authors: Luqmannur Rohman Afifa , Sukmana Raditya
Published: April 2023

ABSTRACT
This research aims to determine the influence of Urbanization, FDI, and Economic Growth on environmental degradation within the OIC member countries. The CO2 Emission variable is used as an indicator of environmental degradation. The analytical method used in this study uses multiple regression analysis with the EVIEWS 9 application. The sample of this study uses OIC member countries in 1995-2018 with 288 observational data. The results of this study indicate that there is a significant positive influence on the variables Urbanization and Economic Growth on CO2 Emissions. While the FDI variable has an insignificant positive effect on CO2 emissions. The scope of this research is limited by the availability of data which is only in the form of 12 countries out of 57 member countries of the Organization of Islamic Cooperation.
Keyword : Urbanization, Foreign Direct Investment, Economic Growth, CO2 Emissions, OIC, Pollution, Environmental Degradation.
 
ABSTRAK
Peneltian ini memiliki tujuan untuk mengetahui pengaruh Urbanisasi, FDI, dan Pertumbuhan Ekonomi memiliki pengaruh terhadap degradasi lingkungan di lingkup negara Anggota OKI. Variabel Emisi CO2 digunakan sebagai gambaran indikator degradasi lingkungan. Metode analisis yang digunakan dalam penelitian ini menggunakan analisis regresi berganda dengan aplikasi EVIEWS 9. Sampel dari penelitian ini menggunakan negara Anggota OKI pada tahun 1995-2018 dengan 288 data observasi. Hasil dari penelitian ini menunjukkan adanya pengaruh signifikan positif pada variabel Urbanisasi dan Pertumbuhan Ekonomi terhadap Emisi CO2. Sedangkan variabel FDI memiliki pengaruh positif tidak signifikan terhadap Emisi CO2. Lingkup penelitian ini terbatasi dengan ketersediaan data yang hanya berupa 12 Negara dari 57 Negara Anggota Organisasi Kerjasama Islam.
Kata Kunci : Urbanisasi, Foreign Direct Investment (FDI), Pertumbuhan Ekonomi, Emisi CO2, OKI, Polusi Udara, Degradasi Lingkungan.
The Impact of Awareness, Certification, and Quality of Halal Food on Consumer Purchase Intentions at Asia Kintan Buffet Restaurant
Authors: Darmawan Firman , Fathurrohman Muhamad Said
Published: April 2023

ABSTRACT
This study aims to obtain empirical evidence regarding the effect of halal certification, halal awareness, and food quality on purchase intention. This study uses a quantitative approach with a questionnaire. The population of the research was UNAIR students for the 2020 academic year with a sample of 376. This study used a linear regression analysis technique using the SPSS application. The results of this study indicate that all three variables have a positive effect on purchase intention.
Keywords: Halal Certification, Halal Awareness, Food Quality, Purchase Intention.
 
ABSTRAK
Penelitian ini bertujuan untuk memperoleh bukti empiris mengenai pengaruh sertifikasi halal, kesadaran halal, dan kualitas makanan terhadap niat pembelian konsumen. Penelitian ini menggunakan pendekatan kuantitatif dengan kuesioner. Populasi dari penelitian adalah mahasiswa UNAIR tahun ajar 2020 dengan sampel sebanyak 376. Penelitian ini menggunakan teknik analisis regresi linier dengan menggunakan aplikasi SPSS. Hasil dari penelitian ini menunjukkan bahwa dari tiga variabel semua berpengaruh positif terhadap niat pembelian konsumen n.
Kata Kunci: Sertifikasi Halal, Kesadaran Halal, Kualitas Makanan, Purchase Intention.
Analysis of packaging recycling patterns using mathematical modeling
Authors:   School of Economics and Management, Tianjin Sino-German University of Applied Sciences, Tianjin 300350, China., Fu Xiaoxi , Sun Xuecheng ,   School of Economics and Management, Tianjin Sino-German University of Applied Sciences, Tianjin 300350, China.
Published: April 2023

With the rapid development of online shopping platforms, China’s express industry has embraced explosive growth, but, at the same time, numerous significant social problems also occur. Regarding the problems, how to deal with the large number of packaging from express delivery has become a growing concern for governments, e-commerce platforms, express enterprises, and ordinary consumers. Abandoned express packaging increases the cost of express enterprises and aggravates the environmental burden. Therefore, based on previous research, this paper tried to establish two recycling models and analyze their benefits through mathematical model deduction. By comparing the results, this paper aimed to set up a model to maximize express enterprises’ revenue from recycling packaging. According to the results, regardless of the governmental subsidies, the revenue from recycling packaging was bound up with the environmental awareness of residents and the recycling price. Through the comprehensive analysis, the author hopes that the results could provide express enterprises with the option of the best recycling model in different contexts and help governments formulate more appropriate recycling policies.
The Shielding and Mechanical Properties of Tungsten/Epoxy Composites
Authors: Zhang Jun Xiang , Nie Shi Wei , Zhang Shuo , Xing Tie Ming , Xiong Hou Hua , Zeng Zheng Kui
Published: April 2023

With the development of nuclear technology application, radiation safety has been widely concerned, and there is an urgent need for novel shielding materials. Among the various options available, non-lead organic composite shielding material has emerged as a promising solution in the field of radiation shielding due to its high strength, easy processing, and light weight. In this study, tungsten/epoxy resin (W/EP) composite samples with tungsten weight fraction from 0% to 60% were prepared. The shielding and mechanical properties of W/EP composites were investigated. The results show that the results showed that the higher the tungsten content, the greater the shielding capacity of W/EP composites, particularly for low-energy gamma ray (γ) shielding. However, the addition of tungsten reduces the impact strength and tensile properties of the material. Overall, for 300 keV γ-ray, W/EP with 30% tungsten content has comparable shielding capacity to ordinary concrete. W/EP composite materials can serve as shielding materials for low-energy γ-rays.
Deriving the Arrhenius Equation and the Pre-Exponential Factor
Authors: Dou Rupeng
Published: April 2023

Proposed in 1889 by Svante Arrhenius, the Arrhenius equation is an important result in physical chemistry which aims to find the relationship between temperature and reaction rates. It is also an essential equation for analytic chemistry which helps to determine the energy barrier for a given reaction. In this article, we will go through a detailed derivation of the exponential factor in the Arrhenius Equation based on the Boltzmann distribution of particle energy probability. Then, we will attempt to model the pre-exponential factor in accordance with the principles of collision theory for bi-molecular reaction with gaseous reactants. Understanding the basic principles of chemical reaction provides valuable tools to analyze complex reaction mechanisms in the perspective of optimizing existing industrial processes.
The Effectiveness of Using the Minnesota Model in Completing University Physics Selection Exam
Authors: Syukri Muhammad , Putri Elva Sesioria , Evendi Evendi , Yusrizal Yusrizal , Hamid Abdul
Published: April 2023

This study raises the issue of whether the Minnesota model in solving university selection physics questions gets the right results in terms of answers and time. This research aims to determine the effectiveness of using the Minnesota problem-solving model for the accuracy of answers and time in solving physics problems. The type of research is quantitative research with experimental methods. The population of this study was students of class XI from senior high school in Banda Aceh. The sample in this study was two classes. There was the experimental class and control class. Determination of the sample is done by purposive sampling. The approach used is a quantitative approach with the type of experimental research. The data was collected using a written test technique and data processing using an analysis of the effectiveness of the accuracy of the answers using an assessment rubric that has been validated and using t-test statistics, as well as the effectiveness of the use of time analysis based on the average time use of the two classes. The results of the data analysis showed that the average value of the experimental class using the Minnesota problem-solving model was higher than the control class, and the experimental class’s time usage was faster than the control class. It was stated that the Minnesota problem-solving model was effectively used in solving physics problems.
Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms
Authors: de Almeida Viviani Mendes , Engel Daiane F , Ricci Mayra Fernanda , Cruz Clênio Silva , Lopes Icaro Santos , Alves Daniele Almeida , Auriol Mirna d’ , Magalhães João , Zuccoli Giuliana S. , Smith Bradley Joseph , Carregari Victor Corasolla , Machado Elayne Cristina , Rocha Victor M. , Carvalho Toniana G. , Lacerda Larisse de Souza Barbosa , Pimenta Jordane C. , Galvão Izabela , Silva Mariana Aganetti , Rosa Erika da Silva , Cassali Geovanni Dantas , Garcia Cristiana C. , Teixeira Mauro Martins , Coelho Leiliane , Ribeiro Fabiola Mara , Martins Flaviano S. , Saia Rafael Simone , Costa Vivian Vasconcelos , Martins-de-Souza Daniel , Marques João T. , Aguiar Eric R. G. R. , Vieira Angelica T.
Published: April 2023

Long-term sequelae after Coronavirus disease (COVID)-19 are frequent and of major concern. SARS-CoV-2 infection affects the host's gut microbiota, which is linked with disease severity in patients with COVID-19. We report here that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with antibiotic-resistance phenotype compared to healthy controls. Additionally, short-chain fatty acids (SCFA) levels were reduced in their feces. Fecal transplant from post-COVID subjects to germ-free mice led to lung inflammation and worst outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. Transplanted mice also had poorer cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection in the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.
Potential Usefulness of a Lifetime Lyso-Gb3 Exposure at Diagnosis and Baseline Modified Disease Severity Score in Early-Diagnosed Patients with Fabry Disease
Authors: Hotta Junko , Jogu Yukiko , Bamba Haruka , Izumiya Yasuhiro , Kudo Masaharu , Imai Takumi , Sakuraba Hitoshi , Hamazaki Takashi , Seto Toshiyuki
Published: April 2023

Background: Fabry disease (FD) is a lysosomal storage disease caused by a deficit of α-galactosidase A (GAL). Recently, plasma globotriaosylsphingosine (lyso-Gb3), a pathogenic analogue of a substrate of GAL, has been suggested as a potential biomarker for FD, and disease severity scores—the Mainz Severity Score Index (MSSI) or the Disease Severity Scoring System (DS3), FASTEX (the FAbry STabilization indEX)—are useful tools for evaluating the severity of signs and symptoms in symptomatic FD patients. However, a more useful method of evaluating disease severity in early-diagnosed FD patient such as children, adult females, and asymptomatic patients is needed. Here, we examined the clinical usefulness of lyso-Gb3 and modified MSSI or DS3 scores for early-diagnosed FD patients.
Result: In 13 early-diagnosed FD patients, we developed modified MSSI and DS3 scores and examined the correlation of lifetime lyso-Gb3 exposure at diagnosis with the conventional or the modified scores. Lifetime lyso-Gb3 exposure was positively correlated only with the modified DS3 score. Additionally, we examined the long-term changes in plasma lyso-Gb3 concentration and in conventional MSSI, DS3 and FASTEX. In male, plasma lyso-Gb3 concentration decreased more rapidly than in females. In all patients, the severity scores were mild and remained nearly stable throughout the follow-up period.
Conclusion: Our data suggest that lifetime lyso-Gb3 exposure and the modified DS3 score are useful in early-diagnosed patients.
A Neighborhood-aware Multi-markovian Switching Particle Swarm Optimization Technique for Solving Complex and Expensive Problems
Authors: Khalil Muhammad Ilyas Khan , Rahman Izaz Ur , Zakarya Muhammad , Khan Mukhtaj
Published: April 2023

Particle swarm optimization approach (PSO) has illustrated promising performance on a variety of optimization problems, two critical issues that must be addressed in PSO research are how to balance conflicts around exploration, exploitation and reasonably distribute computational resources. In this paper, a neighborhood-aware N states markovian switching PSO algorithm (NS-MJPSO$loc$) is proposed, where we have employed local search based approach. The neighborhood of PSO algorithm is a single particle itself in the early stages of optimization. The neighborhood will eventually expand to include all particles as the amount of generations increases. The search space is segmented into N potential states according to the size of problem. The value of N is dependent on the dimension of problem space. Every iteration serves a transition probability-based markovian switching technique to estimate the acceleration coefficients in an adaptable way. The transition probability determines the next state and the adequate values of an acceleration coefficients. Through adopting a local search strategy while interacting with all other particles in the group, perhaps every particle possesses chance of improving itself. Moreover, new features have been incorporated to accomplish accuracy and stability. The primary contributions of the proposed work are to enhance the topological structure of a recently developed PSO variant by using a local search (loc) mechanism rather than a global (gbest). The purpose of this idea is to develop a more adaptable and less sensitive novel version of PSO that can handle multi-modal, highly challenging problems. The proposed algorithm was then tested using a variety of uni-modal, multi-modal and rotated benchmark functions. The experimental findings show that the proposed NS-MJPSOloc outperform most of the current versions in terms of accuracy and convergence time, notably in multi-modal problems.
A NEW Body Mass Index (NBMI)
Authors: Yin Minghui , Liu Caiping
Published: April 2023

Body mass index (BMI) is typically used to define overweight and obesity. However, without waist circumference information, BMI may misclassify as overweight or obese. Therefore, we proposed a new index based on BMI. We developed a New Body Mass Index (NBMI) by adding waist circumference (WC) to BMI, which combined BMI and WC. That is, it also combined weight-for-height and waist-to-height ratios. The formula is: NBMI = BMI × WC (m) = WT (kg) / HT (m2) × WC (m) = WT (kg) / HT (m) × WC (m) / HT (m) = weight-for-height × waist-to-height. Firstly, individuals with the same height and weight have the same BMI, but their waist circumferences could vary considerably, and NBMI could distinguish body differences among people's waist sizes. Secondly, NBMI could better identify central obesity than BMI. Thirdly, NBMI could not only measure body mass but also classify health and obesity degrees according to a wide range of scores. Firstly, NBMI incorporating WC could better reflect the body difference in waist size than BMI. Secondly, NBMI is more convenient for identifying central obesity. Thirdly, NBMI could better classify different weight types by expanding the score range.
Impact of the Covid-19 pandemic on older adults and its association with cognition, mood, and quality of life
Authors: Guimarães Anna Luiza , Reuwsaat Karin , Emele Nwabu , Poltronieri Bruno Costa , Oliveira Yasmin Guedes , Carvalho Cíntia Monteiro , Pelegrino Ana , Lin Feng V , Panizzutti Rogerio
Published: April 2023

The COVID-19 pandemic greatly impacted people's lives, including social interactions, physical and mental health, and the use of technology. This impact may endure even after the vaccination, especially in more vulnerable populations such as older adults. Here, we measured the global impact of the COVID-19 pandemic on older adults with or without mild cognitive impairment (MCI). We used a questionnaire comprising: living arrangements, physical health, information about the pandemic, behaviors adopted in the face of pandemic-related restrictions, financial situation, mental health, and changes in life activities. We primarily asked if the impact would be associated with demographics, cognition, depression/anxiety, and/or quality of life. Secondarily, we wondered whether the pandemic impact would differ between participants assessed before and after the vaccination. In cognitively healthy older adults, a higher pandemic impact was associated with worse cognitive performance and quality of life and increased symptoms of anxiety and depression. In older adults with MCI, higher pandemic impact was associated with increased depressive symptoms. Only healthy older adults had significantly lower pandemic impact scores after vaccination. We conclude that the perceived pandemic impact on older adults was associated with cognition, anxiety, depression, and quality of life. Since the effect of vaccination on decreasing the perceived pandemic impact was not observed in older adults with MCI, interventions to reduce the pandemic impact on this population should be developed and recommended even after the vaccination.
Phytopharmaceutical characterization of Curcuma angustifolia Roxb. collected from Manipur, India
Authors: Yengkhom Abinash , Ningthoujam Teresa , Laldingliani TBC , Saikhom Herojit , Kumar Awadhesh
Published: April 2023

The present study attempted to characterize the phytochemical constituents of the essential oil (EO) extracted from the rhizome of Curcuma angustifolia Roxb. and to assess their antioxidant and antibacterial activity using standard techniques. The investigation of the phytochemicals showed the class of compounds such as glycosides, tannins, proteins, carbohydrates, saponins and terpenoids; however, the total content of phenols and flavonoids was 30.07±0.02mg/100g and 10.29±0.019mg/100g respectively. Antioxidant property of essential oil was evaluated using DPPH and FRPA. Percentage inhibition of the DPPH radical was recorded as the highest at 300 µg/ml (73.32%) with an IC50 of 2.539 µg/ml; and it was observed that the essential oil could also reduce the ferric ions in a concentration-dependent manner. In addition, the antibacterial activities against human pathogenic bacteria were evaluated by estimation of the zone of inhibition (DDA). The zone of inhibition varied from 10.05 ± 0.05mm to 15.5 ± 0.5mm, where, zone of inhibition of 15.5 ± 0.5mm at 100µg/ml was recorded against Bacillus cereus. Further, GC-MS analysis of EO showed the presence of 43 compounds having Epicurzerenone (37.3%) as highest active compound followed by Camphor (14.2%), Coronarin E (5.6%), Germacrone (4%), 1, 4-di-iso-propylnaphthalene (3.6%), borneol trifluoroacetate (3.9%) and N-hexadecanoic acid (2.8%). Thus, the present study demonstrated the medicinal importance of Curcuma angustifolia Roxb. from the North East Region of India, which is a very potent plant that could play an important role in phytopharmaceutical industries for development of new drugs in the coming future.
The Effectiveness of a Balint Group on Burnout Prevention, Reduction of Stress Perception, and Improvement of Caring Behaviors in Nurses in the COVID-19 Ward at Amir-Alam Hospital
Authors: Masoomi Maryam , jamshidnejad nina , kianidehkordi mansoureh , Ghasempour fatemeh , gholamzad shakiba
Published: April 2023

Background:
Nurses have stressful jobs. Considering the frequency of burnout and its consequences in nurses and subsequently the direct impact it has on patients' health, devising interventions is necessary to prevent or reduce burnout. The aim of this study was to evaluate the effectiveness of Balint groups on burnout, perceived stress, and caring behaviors in nurses at the COVID-19 ward, Amir-Alam Hospital.
Methods:
This was a quasi-experimental study with pre-test, post-test and a control group. 20 nurses were selected at the COVID-19 ward, Amir-Alam hospital, using a random sampling method. Twelve online Balint sessions were held. Maslach Burnout Inventory (MBI), Caring Behaviors Inventory (CBI), and Perceived Stress Scale (PSS) were used at the beginning and the end of the intervention to collect data.
Results:
Results showed no significance difference between the experimental and control groups in pre-test and post-test in terms of sum of dependent variables, including Perceived Stress, frequency and intensity of Emotional Exhaustion, Personal Accomplishment, Depersonalization, and Occupation, Respectful Deference to Others, Human Presence, Positive Connectedness, Knowledge and Skills, and Experiences of Others.
Balint group with a limited number of once-weekly sessions (12 online sessions) had no significant effect on burnout, perceived stress, and caring behaviors in nurses at Amir-Alam Hospital. More sessions of Balint group-work in online situation is recommended as opposed to face-to-face Balint sessions.
Preference of musculoskeletal pain treatment in middle-aged and elderly Chinese people: A machine learning analysis of the China Health and Retirement Longitudinal Study
Authors: Mei Fengyao , Dong Shengjie , Li Jiaojiao , Xing Dan , Lin Jianhao
Published: April 2023

Background Musculoskeletal pain is a major cause of physical disability, associated with huge socioeconomic burden. Patient preference for treatment is an important factor contributing to the choice of treatment strategies. However, effective measurements for evaluating the ongoing management of musculoskeletal pain are lacking. To help improve clinical decision making, it's important to estimate the current state of musculoskeletal pain management and analyze the contribution of patient treatment preference.Methods A nationally representative sample for the Chinese population was derived from the China Health and Retirement Longitudinal Study (CHARLS). Information on the patients’ demographic characteristics, socioeconomic status, other health-related behavior, as well as history on musculoskeletal pain and treatment data were obtained. The data was used to estimate the status of musculoskeletal pain treatment in China in the year 2018. Univariate analysis and multivariate analysis were used to find the effect factors of treatment preference. XGBoost model and Shapley Additive exPlanations (SHAP) method were performed to analyze the contribution of each variable to different treatment preferences.Results Among 18814 respondents, 10346 respondents suffered from musculoskeletal pain. Approximately 50 percent of musculoskeletal pain patients preferred modern medicine, while about 20 percent chose traditional Chinese medicine and another 15 percent chose acupuncture or massage therapy. Differing preferences for musculoskeletal pain treatment was related to the respondents’ gender, age, place of residence, education level, insurance status, and health-related behavior such as smoking and drinking. Compared with upper or lower limb pain, neck pain and lower back pain were more likely to make respondents choose massage therapy (P < 0.05). A greater number of pain sites was associated with an increasing preference for respondents to seek medical care for musculoskeletal pain (P < 0.05), while different pain sites did not affect treatment preference.Conclusion Factors including gender, age, socioeconomic status, and health-related behavior may have potential effects on people' s choice of treatment for musculoskeletal pain. The information derived from this study may be useful for helping to inform clinical decisions for orthopedic surgeons when devising treatment strategies for musculoskeletal pain.
Mental Health Care Seeking Behavior in Bangladesh: Evidence from the National Mental Health Survey 2019
Authors: Huque Rumana , Azad Abul Kalam , Islam Khaleda , Ahmed Helal Uddin , Amin Md. Robed
Published: April 2023

Objectives The study aims to explore the existing pattern of mental healthcare-seeking behavior among the adult population in Bangladesh, and to delineate the factors that influence the mental health patients' decision to receive mental healthcare services.Methods We used the National Mental Health Survey Bangladesh 2019 dataset with 7270 households to identify the patterns and catalysts of seeking mental health care services. A Probit model using a standard normal cumulative distribution function (CDF) with three specifications has been applied to identify the factors influencing mental healthcare-seeking behavior and the probability of seeking mental healthcare services in Bangladesh.Results We found that about 19% of the total adult population have mental health disorder in the country. Among the mental health disorder patients, only 10% seek healthcare services from different sources of mental healthcare services. Patients with addictive disorder show the lowest interest in seeking healthcare services, while patients with bipolar-related disorder receive treatment from mental healthcare sources. Findings portray that 4.8% of addictive disorder patients seek healthcare services. On the other hand, 34.4% of bipolar-related disorder patients receive treatment for mental health. In addition, the findings from the Probit model show that only the existence of other mentally disordered family members is the only statistically significant determinant among the socio-economic factors, such as gender, age, religion, education level and residential status. The marginal effects analysis shows that the existence of mentally disordered family members increases the probability of seeking mental health care services by around 6%. The other socio-economic variables considered in the study are found statistically insignificant. However, a married woman has a significantly higher likelihood of seeking treatment than an unmarried woman, while the family size is the only variable that significantly influences treatment-seeking behavior for men.Conclusion Though mental health conditions are major public health concerns in Bangladesh, the treatment-seeking behavior among the mentally diorder people is very low, implying a large treatment gap in the mental health sector. The findings indicate the urgent need to increase mental health service coverage among mental health patients.
The Relationship Between College Students' Sense of Social Connection and Insomnia during the COVID-19 Lockdown in China：A Moderated Mediation Model
Authors: Liu Quzhi , Jiang Xiuya , Zhang Shuo
Published: April 2023

The lockdown due to the coronavirus pandemic may have exacerbated mental health problems. This study aimed to explore the mediating and moderating effects of rumination and exercise between social connectedness and insomnia. A cross sectional survey was employed, a total of 10097 Chinese students completed social connectedness (SCS-R), total active time (IPAQ-SF), rumination and insomnia severity (ISI). The results revealed that: (1) social connectedness had a significant direct predictive effect on insomnia in college students (β = -0.19, t=-48.31, p<0.01), can also indirectly predict the level of insomnia through the mediation of rumination (β = -0.13, t = -32.41, p<0.01). (2) The direct effect of social connectedness on insomnia and the mediating effect of rumination were moderated by exercise. This study supports the view that insomnia may be aggravated during lockdown, which was associated with a decreased sense of social connectedness.
Infrared initiation of frontal polymerization with density gradient multi-layered resins for tunable colored layers via photothermal effect
Authors: Wi Eunsoo , Kim Younghun
Published: April 2023

Frontal polymerization (FP) is a unique polymerization technique that involves the self-propagation of heat, which is triggered by a local heat source, such as a photoinitiator. In this paper, we propose a novel method for producing colorful polymeric layers through an FP reaction using carbon black (CB) under near-infrared (NIR) irradiation. In the FP reaction, CB and dicyclopentadiene (DCPD) were used as the photothermal agent and monomer, respectively. The photothermal efficiencies of the CB/DCPD suspensions were found to increase with the increase in their CB content. After photothermal initiation, the exothermic FP reaction propagated thermally, resulting in the formation of a free-standing poly(DCPD) resin. In addition, the density of the DCPD suspension in the test tube was adjusted to prepare a multilayered, colored poly(DCPD) resin. Consequently, a four-colored poly(DCPD) resin was obtained via an NIR-induced FP reaction. These results indicate that nanosized CB can be an effective photothermal agent for FP and that the proposed approach can be used for the rapid curing of polymers with multicolored layers with low energy consumption.