bluuebunny/crossref_metadata_2025 huggingface dataset:
Kết quả điều trị ung thư tuyến tiền liệt giai đoạn II-IVa bằng xạ trị điều biến liều kết hợp liệu pháp androgen tại Trung tâm Ung bướu Bệnh viện Chợ Rẫy
Authors: Anh Lê Tuấn
Published: May 2023

Mục tiêu: Đánh giá kết quả điều trị ung thư tuyến tiền liệt giai đoạn tại chỗ bằng xạ trị điều biến liều (IMRT) kết hợp liệu pháp ức chế Androgen tại Trung tâm Ung bướu, Bệnh viện Chợ Rẫy. Đối tượng và phương pháp: Mô tả tiến cứu, báo cáo loạt ca, thực hiện trên bệnh nhân ung thư tuyến tiền liệt giai đoạn II-IVa được xạ trị với kỹ thuật IMRT có hướng dẫn hình ảnh cắt lớp vi tính (CBCT) kết hợp liệu pháp ức chế Androgen tại Trung tâm Ung bướu, Bệnh viện Chợ Rẫy từ 01/6/2015 đến 31/12/2021. Kết quả: Trong số 88 bệnh nhân nghiên cứu, tuổi trung vị 68 (khoảng 51-88). Liều xạ được chỉ định từ 72-78Gy. Thể tích lập kế hoạch xạ trị nhận 95% liều xạ trị rất tốt (từ 97% đến 99%). Các cơ quan lành đều trong giới hạn liều cho phép. Trung vị chỉ số PSA trước điều trị là 38ng/ml, sau điều trị là 0,175ng/ml (p=0,023). Tỷ lệ sống còn  không bệnh tiến triển tại thời điểm 2 năm, 3 năm, 5 năm lần lượt là 93,5%, 89,3%, 78,5%. Kết luận: Kỹ thuật IMRT kết hợp liệu pháp ức chế Androgen trong điều trị ung thư tiền liệt tuyến giai đoạn II-IVa là kỹ thuật an toàn và cải thiện tỷ lệ sống còn của bệnh nhân ung thư tuyến tiền liệt giai đoạn tại chỗ.
Kết quả bước đầu điều trị đa mô thức bệnh nhân u nguyên bào thần kinh đệm có làm xét nghiệm methyl hóa MGMT tại Bệnh viện Trung ương Quân đội 108
Authors: Kiên Nguyễn Xuân
Published: May 2023

Mục tiêu: Đánh giá kết quả bước đầu điều trị đa mô thức bệnh nhân u nguyên bào thần kinh đệm tại Bệnh viện TWQĐ 108 và bước đầu đánh giá vai trò của của tình trạng methyl hóa MGMT cùng một số yếu tố ảnh hưởng trong tiên lượng bệnh. Đối tượng và phương pháp: Nghiên cứu mô tả tiến cứu trên 21 bệnh nhân u nguyên bào thần kinh đệm từ tháng 01/2022 đến tháng 12/2022, được phẫu thuật, và hóa xạ trị, hóa trị bổ trợ theo sau. Đánh giá độc tính của hóa xạ trị, đáp ứng trên lâm sàng đối với các bệnh nhân còn u tồn dư, tỷ lệ kiểm soát tại chỗ tại vùng và tỷ lệ sống thêm cùng các yếu tố ảnh hưởng như tình trạng methyl hóa MGMT, IDH, KPS, mức độ phẫu thuật cắt u, chỉ số RPA. Kết quả: Trong nghiên cứu có 9/21 (42,9%) bệnh nhân được phẫu thuật cắt toàn bộ u, 8/21 (38,1%) được cắt u một phần và 4/21 (19%) chỉ sinh thiết u. Tình trạng methyl hóa gen MGMT phát hiện trên 7/21 (33,3%), 50% bệnh nhân làm IDH có đột biến gen. Trên 12 bệnh nhân không cắt được toàn bộ u, sau hóa xạ trị được đánh giá đáp ứng theo tiêu chuẩn RANO cho thấy đa phần bệnh nhân ở trạng thái ổn định 58,3%, 4 bệnh nhân tiến triển (33,3%), 1 bệnh nhân đáp ứng một phần (8,3%). Thời gian sống thêm toàn bộ (OS) trung bình là 367 ± 26 ngày. Sống thêm không tiến triển (PFS) trung vị ở nhóm nghiên cứu là 303 ngày. Tại thời điểm 6 tháng, tỷ lệ sống thêm toàn bộ là 81,2%, tỷ lệ sống thêm không tiến triển là 83,8%. OS trung bình của 2 nhóm bệnh nhân có tình trạng Methyl hóa MGMT và không methyl hóa MGMT lần lượt là: 322 ngày và 373 ngày (p=0,75), PFS trung bình của 2 nhóm có methyl hóa và không methyl hóa MGMT lần lượt là 326 ngày và 270 ngày (p=0,6). Tỷ lệ OS 6 tháng của nhóm cắt toàn bộ u là 100% trong khi ở nhóm không cắt được toàn bộ u là 70,7% (p=0,17). Tỷ lệ PFS 6 tháng của nhóm cắt toàn bộ u là 100%, nhóm không cắt được toàn bộ là 72,9% (p=0,14). Tỷ lệ OS 6 tháng của nhóm ≤ 50 tuổi và > 50 tuổi là 85,7% (trung bình 383 ngày) và 77,1% (trung bình 314 ngày), p=0,55. OS trung bình của nhóm có KPS trước phẫu thuật ≥ 90 cao hơn ở nhóm có KPS < 90 (392 ngày so với 197 ngày, p=0,17). PFS trung bình của nhóm KPS trước phẫu thuật ≥ 90 và < 90 là 317 ngày và 184 ngày (p=0,14). Tất cả bệnh nhân đều dung nạp điều trị tốt, không có độc tính nghiêm trọng đe dọa tính mạng của bệnh nhân. Tác dụng không mong muốn độ 3, 4 chỉ gặp ở 2 bệnh nhân có tăng men gan GOT/GPT (9,5%), còn lại hầu hết là độ 1, 2. Kết luận: Nghiên cứu đã đánh giá bước đầu điều trị bệnh nhân u nguyên bào thần kinh đệm. Các kết quả thu được dựa trên đánh giá thời gian sống thêm toàn bộ và sống thêm không tiến triển. Trong nghiên cứu của chúng tôi mặc dù có sự khác biệt khi so sánh OS, PFS dựa trên có tình trạng methyl hóa MGMT, đột biến gen IDH, nhóm tuổi, KPS, mức độ phẫu thuật cắt u nhưng chưa đủ ý nghĩa thống kê. Nghiên cứu cần tiến hành trên cỡ mẫu lớn hơn và theo dõi lâu dài để đánh giá chính xác hơn.
Clinical and Radiological Profile of Chronic Obstructive Pulmonary Disease in Kinshasa
Authors: Dikamba Fiston Fiondo , Nkodila Aliocha Natuhoyila , Wembonyama Stanis Okitotsho
Published: May 2023

Background and objective: The diagnosis and follow-up of chronic obstructive pulmonary disease (COPD) are essentially based on the clinic and plethysmography. However, medical imaging techniques remain one of the essential examinations in the differential diagnosis with other pathologies and in the detection of complications of COPD. The objective of this study was to describe the clinical and radiological characteristics of patients with COPD followed in Kinshasa.
Material and Methods: Documentary and descriptive study of clinical data and chest imaging (radiography and computed tomography), collected from the files of 120 COPD subjects followed in three medical trainings in Kinshasa between January 2014 and June 2017. The clinical and radiological data were the object of this study.
Results: The study population (mean age of 64.52 ± 16.82 years) was predominantly male (78.3% n=94). The clinic of the patients in this series was dominated by dyspnea (96.7% n=116) and chronic cough (94.2% n=113) followed by far by sputum (47.5% n=57). Cardiometabolic risk (cardiovascular disease and diabetes mellitus), interstitial lung disease were the comorbidities in patients with COPD. The proportions of stage II and III being the most frequent around 80%. Thickening of the bronchial walls (airway damage), centrilobular emphysema (emphysematous damage), dilation of the bronchial lumen (emphysematous damage) and dilatation of the pulmonary artery (vascular change) were more frequent.
Conclusion: The high frequency of COPD risk factors are probably the basis for the observed lesions.

Key words: Clinical, radiological, COPD, Kinshasa.
Copper-DMEDA Catalyzed Carbon-Sulfur Bond Formation for the Derivatization of 5-(3,4,5-Trimethoxyphenyl)-1,3,4-oxadiazole-2-thiol
Authors: Hassan Adrees Hassan Adrees , Zahra Begum Zahra Begum , Haseen Ahmad Haseen Ahmad , Rifhat Bibi Rifhat Bibi , Sania Batool and Abbas Hassan Sania Batool and Abbas Hassan
Published: May 2023

Sulfide linkage plays an important role not only in synthetic chemistry but also has vast applications in drug discovery as a pharmacologically active moiety. Transition metal-catalyzed thiolation is a challenging task as sulfur has a high affinity to bind with transition metal catalysts resulting in catalyst poisoning. Catalyst poisoning results in the inhibition of the reactivity and utility of the reactions. In the current work, a simple and facile method is developed to carry out S-arylation using hetero-aryl thiols and substituted aryl iodides. The reaction conditions were optimized using varied combinations of transition metal catalysts and ligands. The different copper sources included CuCl, CuI, and Cu(OAc)2 different bidentate nitrogen-based ligands including bipyridine, di-tert-butylbipyridine, DMEDA, and sarcosine. The optimized condition consists of CuI as the catalyst and DMEDA as a ligand. The reaction was found to be optimum for a range of aryl iodides in the presence highly basic oxadiazole ring. The coupled products were isolated in excellent yields and show excellent functional group tolerance bearing -NO2, -Cl, -OCF3 groups.
Macroscopic Dimensional Effect of the Composition and Properties of Coatings With Alloys of Metals of the Iron-Tungsten Group During Induced Co-Deposition: Mechanism of Formation and Consequences
Authors: Dicusar A. , Belevskii S.
Published: May 2023

Using the example of obtaining Co-W alloys it is shown that the observed features of the induced co-deposition, including the macroscopic dimensional effect of composition and properties, as well as nanocrystallinity, are a consequence of the fact that the inducing agent (a metal-precipitator complex) is a polymer complex with a high molecular weight. Under conditions with a high current load on the electrolyte, water molecules participate in the electrode process. This leads to the formation of the surface oxide-hydroxide layers and hydrogenation, as well as to an increase in the concentration of tungsten in the alloy due to a “side” reaction of hydrogen release, alkalinization and polymerization of the inducing agent. At a large-scale transfer from laboratory tests to industrial technology, along with maintaining the usual electrochemical parameters, the presence of a macroscopic dimensional effect (dependence of composition and properties on the surface area of electrodeposition) requires to maintain a constant current load on the electrolyte (volumetric current density).
Wiener Schmäh and the Americans
Authors: Luft David S.
Published: May 2023

Kurt Rudolf Fischer was, perhaps more than anyone else in the postwar era, the person who connected the University of Vienna and Austrian students to American intellectual and academic life. He was a beloved teacher and a remarkable human being, who made many friends in both Austria and the United States. On May 12, 2022, the philosophy department of the University of Vienna celebrated 100 years since Kurt’s birth. The following essay was one of the presentations at this international conference.
From the Protocol to the Windsor Framework
Authors: Murray Colin R G , Robb Niall
Published: May 2023

The Windsor Framework, the new package of measures agreed by the United Kingdom (UK) and European Union (EU) as well as the new name for the Protocol on Ireland/Northern Ireland, was presented in February 2023 amidst considerable fanfare. This article examines the rationale for the new Framework amongst the negotiators and how some of its headline provisions impact upon those most exposed to the out-workings of any deal – those living and doing business in Northern Ireland. We investigate the possible implications for Northern Ireland of the new minimalist regulatory alignment in the trade in goods and the possibility of a ‘cooperation dividend’ stemming from warmer UK–EU relations. In particular, we examine the operation and possible limitations upon the ‘Stormont Brake’ mechanism. This article ultimately assesses whether Sunak’s Windsor Framework will be any more successful than the May Backstop and Johnson Protocol before it at ‘getting Brexit done’.
Reporte de caso de granuloma piógeno relacionado a tercera molar inferior
Authors: Mejía Pablo , Velasquez Sthephanie , Castro Tovar Anthony , Cardona Dennis O.
Published: May 2023

El granuloma piógeno es un tumor que tradicionalmente se ha considerado de naturaleza no neoplásica. Es una lesión reactiva a varios estímulos de bajo grado, como ser traumas, fármacos, mala higiene oral, desbalances hormonales, que con el tiempo su estructura se ve modificada, es más común en la cavidad oral. Principalmente se asocia a mujeres sin importar el grupo de edad, debido a un efecto vascular mediado por cambios hormonales. Este reporte de caso tiene como objetivo describir la inusual localización de este tipo de lesión y su tratamiento. Se presenta el caso clínico de una paciente femenina de 17 años de edad quien presenta una lesión nodular de tipo exofítica de consistencia firme y sangrante a la palpación, con un tiempo de evolución de un año, de curso progresivo a nivel de la segunda molar inferior derecha. El diagnóstico definitivo se obtuvo mediante el estudio anatomopatológico dando como resultado una lesión reactiva como ser el granuloma piógeno. Se indicaron exámenes imagenológicos como ser radiografía periapical, radiografía panorámica y hematológicos para su respectivo abordaje quirúrgico que consistió en realizar una biopsia de tipo excisional; al control postquirúrgico se observó una adecuada cicatrización y sin signos de recidiva a los 6 meses de control. Debido a su extraña ubicación se decide documentar y compartir este caso clínico, en el cual se optó por el tratamiento convencional quirúrgico obteniendo una adecuada resolución.
ORGANISMOS MULTILATERAIS E INSTRUMENTOS DE REGULAÇÃO TRANSNACIONAL DE POLÍTICAS EDUCACIONAIS
Authors: Braga Daniel Santos , Silva Débora Cristina Alves da , Duarte Marisa Ribeiro Teixeira
Published: May 2023

O artigo aborda os instrumentos de regulação transnacional de educação e analisa as métricas utilizadas em estudo comparado de condições de oferta das escolas. O objeto de análise foram os relatórios do projeto School Resources Review da Organização para a Cooperação e Desenvolvimento Econômico – OCDE, de três países latino-americanos signatários do programa: Uruguai, Chile e Colômbia. À luz da teoria da ação pública, foi realizado estudo documental nas diretrizes da OCDE para esses países. A hipótese é que ao estabelecer métricas para um estudo comparado, os relatórios também expõem padrões desejáveis de condições de oferta para diferentes países. Dessa forma, a assessoria política prestada pelo projeto atua no sentido de estabelecer uma padronização de procedimentos, para que os países com piores desempenhos executem ações específicas de gestão, que, supostamente, aproximá-los-ia daqueles com resultados.
A referência ao discurso de outrem e persuasão acadêmica na introdução de artigos científicos de iniciantes
Authors: Vilar Vitor , Lima Anny Angélica de Assis Maia de , Silva Nara Karolina de Oliveira , Bessa José Cezinaldo Rocha
Published: May 2023

O discurso de outrem é um recurso de linguagem do qual os pesquisadores se utilizam para referenciar seus pares e construir conhecimento científico. Além de sua dimensão dialógica, referir-se ao discurso de outrem desempenha papel fundamental na persuasão acadêmica. Por assim entendemos e considerando o propósito de conhecer especificidades que caracterizam a escrita científica de pesquisadores iniciantes, objetivamos, neste trabalho, examinar formas e funções da referência ao discurso de outrem e o papel delas na persuasão acadêmica na introdução de artigos científicos produzidos por estudantes de iniciação científica. Como ancoragens teóricas, assumimos trabalhos que discutem a escrita acadêmico-científica em perspectiva sóciorretórica e enunciativo-discursiva. Do ponto de vista metodológico, o estudo se caracteriza como uma pesquisa de natureza interpretativa e abordagem qualitativa. O corpus de análise se constitui de 20 seções de introdução de artigos científicos produzidos por estudantes de iniciação científica da área de Linguística publicados em um periódico científico. As análises apontam que, na introdução dos artigos, os iniciantes mobilizam diversas formas e funções de referência ao discurso de outrem. Apontam ainda uma forte ausência de palavras de outrem para sustentar afirmações e definições feitas pelos iniciantes, o que acaba comprometendo a força persuasiva de seus dizeres nessa seção.
Leitores/autores em práticas de letramentos literários
Authors: Ribeiro Barbosa Luiz Guilherme
Published: May 2023

O artigo procura desenvolver caminhos possíveis de pesquisa em práticas de letramentos literários, considerando, principalmente, o contexto profissional do professor-pesquisador inserido na Rede Federal de Educação Profissional, Científica e Tecnológica. Para isso, estabelece uma compreensão dos letramentos literários, ao eleger conceitos tanto da tradição acerca do ensino de literatura no Brasil, quanto de estudos que procuram estabelecer uma adequada compreensão do termo “letramentos literários” e das práticas que designa. Nesse ponto, reivindica a necessidade de incluir as autorias estudantis em resposta à leitura literária como estratégia para instituir a literatura na vida social da comunidade escolar. Para viabilizar essa perspectiva, propõe-se uma série de Produtos Educacionais (PE), gênero textual acadêmico catalisador, produzido em mestrados profissionais que vem sendo definido em estudos referenciados. O trabalho de proposição de práticas de ensino de literatura em escolas, com base na perspectiva dos letramentos literários, encontra, portanto, na categoria dos leitores/autores um possível caminho inicial para o reconhecimento de escolas como instituições literárias na comunidade a que servem e no território que ocupam.
Investigando representações de transitividade do professor-residente em relatos reflexivos da residência pedagógica no curso de Letras Inglês
Authors: Souza Anderson Alves de , Neto Lauro Ananias da Silva
Published: May 2023

Dentre os vários componentes da Política Nacional de Formação de Professores instituída em 2018, o Programa de Residência Pedagógica representa um estágio essencial na trajetória profissional de milhares de professores/as (BRASIL, 2018). De modo igualmente importante, por promover a reflexão crítica de sua prática docente em formação, a produção de relatos reflexivos constitui uma ferramenta essencial no processo de formação e acompanhamento dos professores-residentes. A presente pesquisa investiga um conjunto de 30 relatos reflexivos produzidos por um professor-residente durante uma disciplina de Estágio Supervisionado do curso de Letras-Inglês da UFPB. O objetivo principal é investigar as formas como o professor-residente representa a si mesmo, a outros participantes e atividades pedagógicas em sala de aula durante seu estágio. A pesquisa tem como arcabouço teórico a Linguística Sistêmico Funcional e o Sistema de Transitividade (HALLIDAY; MATTHIESSEN, 2004). O resultado da análise revelou uma maior quantidade de ocorrências de processos materiais, relacionais e mentais de caráter positivo e com o professor-residente atuando, principalmente, como Ator e Experienciador em atividades que proporcionaram seu desenvolvimento profissional. A escrita de relatos reflexivos se mostrou também uma ótima ferramenta para a reflexão e revisitação da prática docente.
O portão para a intertextualidade: Uma análise do poema Instruções
Authors: Nicolao Anelize
Published: May 2023

Escrito por Neil Gaiman, Instruções é um poema que prescreve orientações para um herói em sua jornada de conto de fadas. Este artigo trata-se de um levantamento de movimentos intertextuais presentes na obra, investigando a relação do poema com os gêneros narrativo, lírico e dramático, constituídos e difundidos em contos de fadas, mitos e literatura fantástica. Os resultados desta pesquisa contribuem para os estudos literários acerca da intertextualidade e a relevância desse recurso na literatura, em especial nos gêneros literários em análise.
Entre dilemas e possibilidades: A BNCC e os povos indígenas
Authors: Beato-Canato Ana Paula Marques , Back Rogério
Published: May 2023

Neste texto, objetivamos problematizar a Base Nacional Comum Curricular (BNCC) a partir do seguinte questionamento: o que a BNCC representa para os povos indígenas e para a sua educação escolar? Para esboçar uma possível resposta, iniciamos tencionando o cenário e as ideologias (VOLÓCHINOV, 2017 [1929] que possibilitam a promulgação de um documento de caráter nacional e obrigatório. A partir disso, descrevemos algumas das características da Educação Escolar Indígena e os avanços emergidos a partir da promulgação da Constituição Federal aos povos originários, como o direito a uma educação escolar específica e diferenciada. Logo após, desde a visão de pesquisadores indígenas como Baniwa (2019), elencamos os avanços e a contribuição indígena na versão final da BNCC. Para esse exercício, trouxemos excertos da Base – Ensino Fundamental – que ilustram possibilidades de trabalho com a temática indígena em sala de aula. Ademais, trazemos fragmentos de três Projetos Políticos Pedagógicos distintos para ilustrar a transposição da BNCC em outros documentos educacionais. Em nossa percepção, apontamos que algumas políticas (educacionais) trouxeram mudanças importantes, já a BNCC, embora seja um direito dos indígenas, pode contribuir para modificações necessárias ou para retrocessos, o que vai depender significativamente de outras políticas linguísticas, de cada instituição e do corpo docente.
Beyond the Brochure: The Role of Diversity and Inclusion in Shaping the Future of American Tourism Industry
Authors:   The Jonathan M. Tisch Center of Hospitality, New York University, Ritchie Stanley K.
Published: May 2023

This paper investigated the critical role of diversity and inclusion (D&I) in shaping the future trajectory of the American tourism industry. As global demographics shift and cultural interchanges expand, the need for a more inclusive and diverse representation in tourism becomes increasingly significant. The industry’s potential for growth hinges on its capacity to mirror this diversity, and to inclusively represent the array of experiences, identities, and backgrounds that constitute contemporary society. The research emphasizes the necessity of moving beyond the traditional brochure-style of advertising a model often laden with stereotypes and narrow perspectives. It proposes a new model that embraces diverse narratives and perspectives, reflecting the multifaceted nature of American society and the global community at large. The paper explored how this inclusive approach not only broadens market appeal but also fosters a sense of connection and belonging among underrepresented groups, thus promoting more sustainable tourism practices. Furthermore, the paper underscores the potential economic benefits of D&I in the tourism industry. It elucidates how a commitment to D&I can translate into increased revenues by attracting a broader audience base, fostering loyalty, and enabling the industry to stay relevant in a rapidly evolving global context. The study also investigated the role of technology and digital transformation in facilitating D&I, highlighting innovative solutions such as virtual reality, AI-based personalized travel experiences, and social media platforms that democratize information sharing and representation. Ultimately, this research underscores the imperative to shift from a tourism model dominated by homogeneous narratives to one that celebrates diversity and fosters inclusivity. It posits that in doing so, the American tourism industry will not only contribute to a more equitable society but also secure its own sustainable and prosperous future. Keywords: Diversity and Inclusion, American Tourism Industry, Sustainable Tourism Practices, Digital Transformation in Tourism, Representation and Narratives
DEVELOPMENT AND VALIDATION OF A GREEN LIQUID CHROMATOGRAPHICDIODE ARRAY DETECTION METHOD FOR SIMULTANEOUS QUANTIFICATION OF CAPECITABINE AND LAPATINIB IN PHARMACEUTICALS USING ANALYTICAL PROCEDURE DEVELOPMENT CONCEPT
Authors: Panda Sagar S. , Patro Budi C. , Bera Ravi Kumar V.V. ,   Department of Pharmaceutical Analysis & Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Odisha, India
Published: May 2023

Capecitabine and lapatinib are two potent anti-breast cancer drugs used in combination for better therapeutic effects. The current study aims to develop a robust liquid chromatographic method to quantify capecitabine and lapatinib using the concept of analytical procedure development. Risk assessment earmarked critical method variables, and their effect on critical analytical attributes was investigated using a Box-Behnken design. The optimized chromatographic conditions use acetonitrile: 10 mMol L-1 phosphate buffer of pH 3.11 (60:40 V/V) as the mobile phase. The separation was achieved on a C-18 column (250 mm × 4.6 mm, 5 µm), and the mobile phase flow was 0.9 mL min-1 with a diode array detection at 310 nm. The developed method was specific, linear (2 - 64 µg mL-1), accurate (> 99 %), precise (RSD < 1 %), sensitive and selective (recovery > 100 %) for quantification of the said drugs from dosage forms and biological fluids. Employing the analytical eco-scale approach revealed excellent method greenness for routine quantification of capecitabine and lapatinib in various samples.
AI IN PHARMACY EDUCATION: EMBRACE THE TECH
Authors: Joshi Dr. Urmila
Published: May 2023

Dear Reader, The field of Education has a new buzzword, Artificial Intelligence (AI). AI is set to reshape the path of learning of an undergraduate, postgraduate and even a doctoral student. AI will open the door to a number of opportunities to help beat the obstacles on the road of learning. AI not only helps in correcting grammar, paraphrasing, searching for relevant references, analysing and summarizing articles and making PowerPoint Presentations but also assists in writing resumes, cover letters and even in the writing of funding applications. And the story continues. AI has a potential to transform education by enabling personalized learning experiences, automating administrative tasks and improving student outcomes. AI tools can analyse student performance data, provide real time feedback and adapt learning materials to suit individual needs.
Publishing Research Output Continuously (PROCess): The case of modular publishing
Authors: Hartgerink Chris , Field Sarahanne , van Ravenzwaaij Don
Published: May 2023

A grant proposal for the Dutch Research Council's Open Science Fund. The summary: Many new tools are built in the effort to open science, some with the idea that their mere presence will resolve underlying problems. Making impactful cultural change, however, is an ongoing social effort. In this project, we team up with ResearchEquals to create a community of practice for modular publishing in the Netherlands. Specifically, we provide multiple training sessions on how to get started with publishing each step of the research process, accompanied by an ethnographic study of the participating researchers. To sustain the training materials beyond the grant runtime, we create an open educational handbook.
Hubungan Pendidikan Agama Kristen Dengan Amanat Agung Dalam Matius 28:19-20
Authors: Pakpahan Duma Fitri , Sihombing Dona Noveria , Ningsih Hesty Widia , Deak Victor
Published: May 2023

The great commission contained in Matthew 28:19-20 if not understood in its entirety will lead to shallow understanding. And as a result, God's real purpose cannot be achieved because part of the implementation process has been neglected or only partially emphasized. In this study, the literature study research method was used by describing the general understanding of education, the nature and scope of Christian Religious Education, understanding the great mandate and the keywords contained in it and then providing an understanding of the inseparable relationship of the great mandate. It was found that the Great Commission could not be carried out without systematic Christian Religious Education and Christian Religious Education also played a role in evaluating the spiritual growth of God's congregation.Keywords: christian education, great commission, mathew 28: 19-20 AbstrakAmanat agung yang terdapat dalam Matius 28:19-20 apabila tidak dipahami secara keseluruhan akan menimbulkan pemahaman yang dangkal. Dan akibatnya tujuan Allah yang sesungguhnya tidak dapat tercapai karena sebagian dari proses pelaksanaan yang ditetapkan terabaikan atau hanya  menekankan sebagian. Dalam Penelitian ini digunakan metode penelitian studi pustaka dengan menguraikan pengertian pendidikan secara umum, hakikat dan ruang lingkup Pendidikan Agama Kristen, pengertian amanat agung dan kata kunci yang terdapat didalamnya kemudian memberikan pemahaman tentang hubungan amanat agung yang tidak dapat terpisahkan. Ditemukan bahwa Amanat agung tidak dapat terlaksana tanpa adanya Pendidikan Agama Kristen yang sistematis dan Pendidikan Agama Kristen juga berperan untuk mengevaluasi pertumbuhan kerohanian jemaat Tuhan.Kata Kunci: pendidikan agama kristen, amanat agung, matius 28: 19-20
Peran Kecerdasan Spiritual Terhadap Generasi yang Dipulihkan
Authors: Ginting Saronisa
Published: May 2023

AbstractAlong with the times and advances in science, affects various aspects of human life. On the one hand, with the advancement of human civilization, the realization of a modern human, a prosperous life, and facilities in several ways/fields. Spiritual intelligence means intelligence related to the psyche, mind, and instincts, while the restored generation is the generation that has managed to win over the negative effects of the times and become influencers. This article discusses the role of Spiritual Intelligence in the Restored Generation. Where will be discussed in several subtitles, namely 1) Spiritual Intelligence (Spiritual Quotient, the definition of spiritual intelligence, restored generation, recovered generation from temptation and challenges of depravity (Proverbs 7: 7); 4) The Role of Spirituality in the Restored Generation (Psalm 119: 9); The Restored Generation can Become a Source of Inspiration (1 Timothy 4:12), and the conclusion is that spiritual intelligence is a must-have for everyone, the virtue of spiritual intelligence is to form the correct attitude and perspective towards all aspects of life, a person who has a spiritual intelligence who well in Christ, of course, the wisdom and outlook on life will be more than anything else Keywords: intelligence, spiritual, generations, restored AbstrakSeiring perkembangan zaman dan kemajuan IPTEK, mempengaruhi berbagai aspek pada kehidupan manusia. Disatu sisi dengan kemajuan peradaban manusia terwujudnya manusia yang modern kehidupan yang sejahtera serta kemudahan-kemudahan dalam beberapa hal/ bidang. Kecerdasan spiritual berarti kecerdasan yang berkaitan dengan kejiwaan, batin, dan naluri, sedangkan generasi yang dipulihkan yaitu generasi yang berhasil menang dari dampak negatif zaman dan menjadi pemberi pengaruh. Artikel ini membahas tentang peran Kecerdasan Spiritual Terhadap Generasi yang Dipulihkan dalam beberapa sub judul yaitu  Kecerdasan spiritual (spiritual quotient, defenisi kecerdasan spiritual, generasi yang dipulihkan, generasi yang dipulihkan dari godaan dan tantangan kebobrokan (Amsal 7:7); Peran spiritualitas terhadap generasi yang dipulihkan (Mazmur 119:9); generasi yang dipulihkan dapat menjadi sumber inspirasi (1 Timotius 4:12), dan kesimpulannya bahwa kecerdasan spiritual wajib dimiliki oleh setiap orang, keutamaan dalam kecerdasan spiritual adalah untuk membentuk sikap dan cara pandang yang benar terhadap segala aspek kehidupan, seseorang yang memiliki kecerdasan spiritual yang baik didalam Kristus, tentunya hikmat dan pandangan hidup yang dimiliki akan melebihi apapun Kata Kunci: kecerdasan, spiritual, generasi, dipulihkan
Strategi Peningkatan Kualitas Pelayanan Kaum Muda di Gereja Kemah Injil Indonesia Tenggarong Jalan Maduningrat
Authors: Wirano Yolanti Inneke , Panggara Robi
Published: May 2023

The church plays an important role in youth ministry and also has a responsibility to create an effective youth ministry through its youth ministry strategy. Effective youth ministry can make the worship atmosphere more qualified and have results which means new souls in the fellowship. The method used in this research is quantitative with approaches through observation and interviews to obtain results. It was found that to overcome the problems in youth ministry must be overcome by: 1). Discipleship, 2). Teaching, 3). Cell community (Komsel) , 4). Innovative worship, 4). Worship Leader Development, 5). Music coaching. These things can work well if there is cooperation from pastors and youth ministry administrators. Keywords: ministry, strategy, youth, quality AbstrakGereja berperan penting dalam pelayanan pemuda  dan juga memiliki tanggungjawab dalam menciptakan pelayanan pemuda  yang efektif melalui strategi pelayanan pemuda yang dibuat. Pelayanan pemuda yang efektif dapat membuat suasana ibadah lebih berkualitas dan memiliki hasil yang artinya adanya jiwa-jiwa  baru dalam persekutuan. Metode yang dilakukan dalam penelitian ini adalah  kuantitatif dengan pendekatan-pendekatan melalui observasi dan wawancara untuk mendapatkan hasil.  Ditemukan bahwa untuk mengatasi persoalan  dalam pelayanan kaum muda harus diatasi dengan: 1). Pemuridan, 2). Pengajaran, 3). Komunitas sel (Komsel) , 4). Ibadah yang inovatif, 4). Pembinaan Worship Leader, 5). Pembinaan musik. Hal-hal ini dapat berjalan dengan baik jika adanya  kerja sama dari gembala dan para pengurus pelayanan kaum muda. Kata Kunci: pelayanan, strategi, pemuda, kualitas
Pendampingan Usaha Melalui Program Score Terhadap Perkembangan Usaha Sayuran Organik Shanti Bhuana Bengkayang, Kalimantan Barat
Authors: Lusiani Lusiani , Mala Rosita , Manggu Blasius
Published: May 2023

Usaha organik merupakan bagian integral dari pertanian berkelanjutan dengan menggunakan bahan alami. Shanti Bhuana merupakan perguruan tinggi yang ada di Kabupaten Bengkayang. Shanti Bhuana memiliki usaha sayuran organik yang dikelola oleh mahasiswa/i. Kendala yang dialami Sayuran organik Shanti Bhuana sebelumnya yaitu kesulitan pemasaran dan keterbatasan SDM yang mengelola usaha sayuran organik tersebut. Kesulitan pemasaran diakibatkan masa pandemi sehingga membuat mahasiswa sulit untuk memasarkan produk secara langsung ke konsumen. Dan sdm dari usaha sayuran organik ini memiliki keterbatasan dalam mengelola sayuran karna tektur tanah yang kurang memadai untuk menanam sayuran. Sehingga dengan adanya kendala yang dimiliki oleh usaha sayuran organik Shanti Bhuana maka dilakukan pendampingan dengan menggunakan modul dari ILO-SCORE. Modul tersebut berupa Sisih, Susun, Sasap, Sosoh, dan Suluh (5S), Hygiene, Kesehatan, dan Keselamatan Kerja (K3). Setelah berjalan 2 bulan pengabdian dilakukan hasil panen mulai meningkat sehingga pendapatan juga mengalami peningkatan.
Kegiatan Melukis sebagai Media Rekreasional pada Pasien Rawat Inap Rumah Sakit Jiwa Sambang Lihum
Authors: Lavenia Ayu , Febriana Mia , Rahayu Sri , Fadhila Mahdia , Faridah Siti , Budianto Zhulfikri
Published: May 2023

Ruang rehabilitasi psikososial menjadi wadah bagi pasien dengan gangguan jiwa untuk mengasah dan mengembangkan kemampuan, terutama pada bidang yang diminati. Kegiatan rehabilitasi mengarah pada aktivitas okupasi seperti mencuci kendaraan, membuat telur asin, hidroponik, dan sebagainya. Kurangnya kegiatan yang bersifat rekreasional, membuat tim ingin melakukan kegiatan di bidang kesenian yakni melukis. Kegiatan melukis bertujuan untuk memberikan aktivitas yang sifatnya rekreasional, meningkatkan keterampilan interaksi sosial, dan menghibur pasien. Metode yang digunakan menggunakan skala pengukuran Wong Baker Faces Pain Scale. Pelaksanaan kegiatan melukis dilakukan di ruang rehabilitasi psikososial Rumah Sakit Jiwa Sambang Lihum. Sasaran kegiatan ini adalah pasien rawat inap yang mengikuti rehabilitasi psikososial di Rumah Sakit Jiwa Sambang Lihum. Adapun jumlah pasien yang mengikuti kegiatan melukis adalah sebanyak 15 orang dengan kriteria kooperatif, sudah tenang, dan telah mendapat persetujuan oleh dokter spesialis. Hasil dari kegiatan ini menunjukkan 8 pasien mengalami kenaikan perasaan menjadi lebih senang, sementara pada 7 pasien menunjukkan perasaan mereka yang sama saja, yang mana perasaan mereka turut mengalami perubahan menjadi merasa senang dan bahagia.
Biomass/productivity and nutrient retention in some Dalbergia sissoo Roxb. plantations of Punjab, India
Authors: Rawat Laxmi , Kamboj S. , Kholiya Deepak , Kandwal Arun
Published: May 2023

The biomass and nutrient distribution in Dalbergia sissoo Roxb. Plantations of different ages (25-33 years) has been studied at six sites at Nara, Chaksadhu, Dhirowal, Kharkan, Dharamkot and Kamalpur of Hoshiarpur, Feerozpur and Amritsar Forest Division of Punjab. The biomass ranged from 83.56 kg tree-1 to 1516 kg tree-1 and from 85.42 to 1226.94 t ha-1 in all these sites. Productivity ranged from 2.59 t ha-1 yr-1 (at 33 yrs) to 9.28 t ha-1 yr-1 (at 25 yrs). The contribution of individual tree components to total biomass varied as: leaf 0.65 to 3.86%; twig 1.62 to 5.64%, branch 10 to 24.88%, bark 8.49 to 12.27%, root 14.98 to 20.58% and bole 42.98 to 58.76%. The percent contributions of all tree components in all the sites were in the order of bole > root > branch > bark > twig > leaf. Prediction models have been worked out by using allometric regressions. Among prediction variables tried D2H were found the most reliable parameters for prediction of biomass. The amount of various nutrients varied from N-691.12 to 2087.24 kg ha-1 P-26.33 to 98.05 kg ha-1, K-470.2 to 1305.4 kg ha-1, Ca-725.05 to 3306.38 kg ha-1 and Mg – 58.33 to 141.20 kg ha-1, respectively. The percentage contribution of different nutrients to total nutrients were as; N (24.57 to 42.41%), P (1.28 to 2.1%), K (16.69 to 31.95%), Ca (28.25 to 54.79%) and Mg (1.51 to 4.27%), respectively. Nutrient losses through complete harvesting have also been discussed and some suggestions have been made to replenish the nutrient loss and improve the site productivity.
Citrus crop performance and fruit quality in response to different scion-rootstock combinations
Authors: MARTINS Rafaelly C. , LEONEL Sarita , SOUZA Jackson M. A. , LEONEL Magali , PUTTI Fernando F. , ZÜGE Patrícia G. U. , FERREIRA Rafael B. , SILVA Marcelo S. , DUARTE FILHO Jaime
Published: May 2023

Aim of study: To address diversification of citrus cultivars to increase the variety and profitability of orchards to adapt them to environmental changes.
Area of study: State of São Paulo, a subtropical region of southeastern Brazil.
Material and methods: The study evaluated the phenological intervals, thermal sum, vegetative and productive performance, and fruit quality of the sweet orange cultivars ‘Rubi’ (R), ‘Lue Gin Gong’ (LGG) and ‘Valencia Delta Seedless’ (VDS) grafted onto 'Rangpur' lime (RL) and 'Swingle' citrumelo (SC). The field experiment was conducted over consecutive growing seasons 2018-2021.
Main results: The duration of the phenological intervals was little influenced by the rootstocks. The harvest time was approximately 245 days after anthesis (DAA) for R, 402 DAA for LGG, and 407 DAA for VDS, regardless of rootstock. Scion cultivars grafted onto RL showed larger canopy volumes and greater weight, length, and diameter of fruits than those of SC trees, and the combinations with SC were more productively efficient than RL due to lower canopy volume. The R scion cultivar presented superior yield performance and fruit colouration than LGG and VDS. The physicochemical quality of the fruits showed improved results with the combinations of LGG/RL, LGG/SC, VDS/RL, and VDS/SC.
Research highlights: These results may be useful when planning the diversification of scion/rootstock combinations for new orchards, identifying dual-market orange cultivars for industrial processing and natural consumption, and determining the combinations that are better adapted to undesirable climatic conditions.
Consumers’ acceptability and sensory evaluation of a traditional local fresh potato variety
Authors: BALLCO Petjon , GOMEZ Miguel I. , GRACIA Azucena
Published: May 2023

Aim of study: This research explores consumers’ acceptance and sensory evaluation, and measures the willingness to pay (WTP) for the most important attributes of a locally grown fresh potato variety.
Area of study: Aragon, Spain.
Material and methods: Data were collected from two experiments. Experiment 1 (shopping stage) explored the product positioning and reveals consumers’ acceptance using three measurements: visual appearance rating, purchase intent, and WTP. Experiment 2 (consumption stage) corresponds to a sensory ranking task (e.g., taste, smell, texture) conducted at home once the local potato was fried.
Main results: Consumers positively valued the visual appearance and were willing to purchase the local potato. The higher the ratings of visual appearance, the higher the consumers’ intention to purchase the product. Women and participants who purchased food from supermarkets were more likely to buy the local potato. Conversely, consumers over 55 years old and those who belong to a lower level of household monthly income were willing to pay less for the local potato. After tasting, the participants’ rating of the product remained unchanged; however, there was a negative rating of the odor once the local potato was fried.
Research highlights: Potato producers and vendors should consider that consumers associate the local origin label with observable (e.g., appearance of color, shape) and unobservable (e.g., taste, smell, texture) attributes. Therefore, in addition to promoting the local origin and the benefits of purchasing and consuming local food, further consideration should be given to featuring physical quality aspects such as the sensory properties of the food that are important to consumers.
Knowledge Attitude and Practice of Students Towards Online Communication in EFL
Authors: Banafi Norah
Published: May 2023

Online learning refers to education that occurs through the Internet using technological tools such as tablets, smartphones, laptops, and PCs. This study intends to determine how structural equation modeling (SEM) can be used to evaluate the adequacy of the variables included in the knowledge, attitude, and practices (KAP) model concerning online communication in English as a foreign language (EFL). An exploratory study was conducted with 112 female undergraduate English language program (ELP) students at the King Khalid University of Saudi Arabia. A KAP questionnaire was distributed to those students using a Google form. The data analysis was carried out using SPSS version 20. The SEM analysis was conducted using Analysis of Moment Structures (AMOS) software version 5.0. The results showed that the mean score of KAP toward online communication in EFL was 3.78, 3.90, and 3.70, respectively. The mean practice score is lower than the mean knowledge and attitude score. The SEM analysis demonstrated that the variables used in the KAP model are positively related (p<0.05). Variables used in the KAP questionnaire are adequately fit to evaluate the ELP students’ KAP toward online communication in EFL. Hence, policymakers can utilize these variables to assess the students’ KAP toward online communication in EFL at HEIs. The findings of KAP can aid universities in framing and implementing appropriate strategies to motivate online communication and enhance the student’s English language skills.
MENILAI TINGKAT PERUBAHAN LABA PERUSAHAAN BERDASARKAN PERUBAHAN NILAI RATIO PROFITABILITAS
Authors: Sinaga Saria
Published: May 2023

Penelitian ini dilatarbelakangi bahwa begitu pentingnya arti laba bagi investor dan kreditor, sehingga terdapat upaya untuk memprediksi laba suatu perusahaan. Prediksi perubahan laba perusahaan dapat dilakukan dengan menggunakan variabel-variabel yaitu Gross Profit Margin (GPM), Net Profit Margin (NPM), Return on Asset (ROA) dan Return on Equity (ROE) yang terdapat dalam laporan keuangan suatu perusahaan. Tujuan dari penelitian ini dilakukan adalah untuk mendapatkan bukti empiris pengaruh rasio profitabilitas terhadap prediksi perubahan laba. Metode penelitian yang digunakan adalah metode pendekatan kuantitatif dan teknik analisis regresi linier berganda. Penelitian ini menggunakan data laporan keuangan 5 anak perusahaan PT PLN (Persero), periode tahun 2019-2021. Pengujian hipotesis dilakukandengan menggunakan uji signifikansi simultan (Uji-F) dan uji signifikansi parsial (Uji-t) dengan tingkat signifikansi 5%. Pengolahan data dilakukan dengan menggunakan software Statistical Product and Service Solutions (SPSS) ver. 20. Hasil Uji Signifikansi Simultan (Uji-F) menunjukkan bahwa secara simultan variabel GPM, NPM, ROA dan ROE memiliki pengaruh signifikan terhadap Perubahan Laba pada anak perusahaan PT PLN (Persero). Hasil uji Signifikansi Parsial (Uji-t) menunjukkan bahwa variabel GPM, NPM, ROA berpengaruh signifikan terhadap Perubahan Laba, sedangkan variabel ROE berpengaruh tidak signifikan terhadap Perubahan Laba pada anak Perusahaan PT. PLN (Persero).
Headache during pregnancy
Authors: Lusnikova Iya
Published: May 2023

Headaches are a common neurological complaint during pregnancy. Most are primary and benign but secondary headaches may also occur. In the first trimester, the complaints are mainly due to primary headaches, and in the last trimester, the proportion of secondary headaches increases. This article provides clinical characteristics of secondary headaches during pregnancy. The limited range of drugs that can be used during pregnancy, in the absence of potential adverse effects on the mother and fetus/newborn, causes certain difficulties in the management of these patients. This review will consider approaches to the treatment of headaches during pregnancy. A non-drug therapeutic strategy is preferred for the treatment of primary headaches during pregnancy. Treatment should not be delayed because uncontrolled headaches can have negative effects on both the mother and the fetus. If non-drug therapy does not lead to the expected control of headache attacks, a choice should be made regarding the use of drug therapy while weighing the benefits and risks of such a choice.
Ethnomedicinal plants used for controlling hypertension by the people of Churachandpur district Manipur
Authors: Hoikhokim Hoikhokim
Published: May 2023

Hypertension, also called high blood pressure is a transitory or excessive elevation of the blood pressure in the arteries, i.e., the systolic and diastolic pressure. A hypertensive crisis is defined as a systolic rate over 180 mmHg or a diastolic rate above 120 mmHg. In India, hypertension affects all ages especially people from lower social economic groups and more common in older people around and above the age of 45 years. Most blood pressure medicine has side effects. Herbal medicines are in great demand both in developed and developing countries. Herbal medicines have been in use for thousands of years. It is estimated that 80% of the world population depend on herbal medicinal products as a primary source of healthcare and traditional medical practices. The choice of herbal medicines for treatment is due to its less side effects, cheap prices and availability of the material within their reach. Churachandpur district is situated in the southern part of Manipur and is inhabited by various communities with common ancestor, sharing similar language, culture, tradition and food habits. These indigenous people are rich in traditional knowledge, but economically backward. Despite the advancement in modern pharmaceutical medicines, many rural and urban people still depend upon traditional ethno medicinal plants for their treatment. They used different types of plants for treating different types of ailments and diseases. But their traditional knowledge on herbal medicine is yet to be documented. Therefore, the aim of this research work is to document the plants used by the people of Churachandpur district for treatment and controlling hypertension.