bluuebunny/crossref_metadata_2025 huggingface dataset:
Financial Feasibility Analysis of Constructed Wetland Phytoremediation WWTP (Case Study: Faculty of Agricultural Technology, XYZ University)
Authors: Novita Elida , Rahmadaningtyas Resta Dwi Ismaniar
Published: February 2025

Laboratory activities at the Faculty of Agricultural Technology, University of XYZ produce wastewater that is still dumped directly into the environment. Wastewater content such as pH, TDS, TSS, BOD and COD that exceed quality standards cause potential damage to the environment, especially the river environment. The construction of the constructed wetland phytoremediation wastewater treatment plant aims to manage laboratory wastewater to be safe when it is made into the environment. The purpose of this study is to calculate the value of financial feasibility and cost-benefit value of wetland phytoremediation wastewater treatment plant. The results of the calculation of the value of financial analysis by the method of analysis NPV, IRR, BCR, PBP, shows the NPV value of Rp. 7.456.063; IRR value of 12%; BCR value of 1,06%, and PBP value for 1 year so that the wastewater treatment plant construction project feasible. The value of benefits to costs has a value of 1,05 means the project is feasible because the value of the benefits provided is greater than the costs used.
The Role of Islamic Society in the Ecological Management and Sustainable Development
Authors: Susetyo Budi , Wibowo Rimun , Ar Radi Mohammad , Taqwa Hafiz
Published: February 2025

The phenomenon of environmental damage is a very serious global issue and an increasingly complex problem.  This damage is due to the exploitation of excess economic value without considering future sustainability (over exploitation).  This happened after humans practiced the capitalist economy while ignoring Islamic values.  Various efforts to overcome this environmental damage have been carried out, including various policies and regulations that regulate human activities in interacting with their environment as measured by the achievements of SDG's (Sustainable Development Goal's).  Experts have also tried various applications of concepts and theories as well as models of approaches and technologies that are possible to overcome the problem.  These efforts so far have not significantly paid off, in fact, tending to increase the level of environmental damage.  The idea of returning to the application of religious values and spirituality is one of the alternatives that needs to be applied through a holistic approach.  The purpose of writing this article is to develop a model of the role of Islamic society in environmental management and sustainable development.  Exploratory methods are used to map the role of Islamic communities in environmental restoration and rehabilitation movements, eco-islamic boarding school, and non-governmental organizations that are active in the community and also through Islamic dawah content.  The results showed that there is a significant role that can be used as a role model, so that it can be replicated by other Islamic societies around the world.
Relationships between burnout, self-esteem and psychologicalwell-being in university students
Authors: Lakatos Csilla , Juhász Eleonóra , Rucska Andrea
Published: February 2025

The authors conducted a quantitative cross-sectional study to investigate the
relationships between burnout, self-esteem and psychological well-being among university
students in the health sciences. The aim of the study was to uncover the psychosocial risk
factors that may influence students’ health behaviors and mental health status. A total of 281
full-time students (n = 281; 14.9% male; 85.1% female) from the Faculty of Health Sciences
at the University of Miskolc took part in the study (mean age: 21.1 years; standard deviation:
2.9). According to its composition, 54.1 of the sample consisted of physiotherapists, 15.8%
of public health nurses, 14.3% of medical diagnosticians, 10% of health tourism managers
and 5.7% of nurses. In addition to socio-demographic questions, the survey used the Student
Burnout Inventory to measure burnout, the Rosenberg Self-Esteem Scale (RSES-H) to
measure self-esteem, the Perceived Stress Scale (PSS-10) to measure the subjective
experience of stress and the Depression Anxiety Stress Scales (DASS-21) to assess mental
health. The results indicate that the self-esteem and psychological well-being of university
students are strongly correlated with the likelihood of burnout. Furthermore, these things
have a significant impact on their health behaviors and health status. An inappropriate career
choice and a lack of support from the environment can lead to a change of subject or even
dropping out of college. The findings highlight the complex issues of student burnout and
dropout and emphasize the role of educational institutions in providing early detection and
appropriate support, which are essential for maintaining student well-being and achieving
academic success.
FRP betétek alkalmazása betonszerkezetekhez a világban : 1. rész – francia megközelítés
Authors: Somlai Bálint , Balázs L. György , Sólyom Sándor
Published: February 2025

A szálerősítésű polimerek (FRP – Fibre Reinforced Polymer) építőmérnöki használata, azok kedvező tulajdonságainak köszönhetően egyre elterjedtebb. Ezzel egy időben a használatukkal, viselkedésükkel és
tulajdonságaikkal kapcsolatos kutatások eredményei egyre átfogóbb képet adnak róluk. Széleskörű tapasztalat hiányában azonban nehéz kiválasztani a tervezéshez szükséges információt . Ebben segítésül szolgálhatnak a különböző munkacsoportok által kiadott jelentések, ajánlások. Ezekre több példa létezik az
FRP betétek felhasználásával (FRP erősített) szerkezetekre vonatkozóan, többek között francia, japán és
kanadai kutatóktól. Jelen cikksorozat ilyen dokumentumokat hasonlít össze, azok tartalma és filozófiája
szerint. Ezek a Francia Építőmérnök Egyesület (AFGC – Association Francaise de Gene Civil), a Japán
Előfeszített Beton Intézet (JPCI – Japan Prestressed Concrete Institute) és a Kanadai Szabványügyi Testület (CSA – Canadian Standards Association). Az összehasonlítás célja, hogy összefoglalja és bemutassa a
szakirodalomban elérhető méretezéssel kapcsolatos ajánlásokat, azok részleteit és vonatkozásait. Ezen cikk
a kiadó szervezetek bemutatását, valamint az AFGC dokumentum leírását tartalmazza.
Vasbeton hidak intelligens monitoringja digitális iker és mesterséges intelligencia alkalmazások használatával
Authors: Al-Hijazeen Asseel , Koris Kálmán
Published: February 2025

A vasbeton hidak biztonsága és fenntarthatósága jelentősen növelhető a szerkezet működés közbeni állapotának folyamatos monitoringjával és ennek révén a különböző terhelési körülmények között várható
viselkedésük és állapotuk pontosabb előrejelzésével. A monitoring rendszer által mért adatok alapján, digitális iker (DI) és mesterséges intelligencia (MI) alapú eszközök használatával a szerkezet statikai állapota
valós időben követhető, és a megfelelő határértékek definiálása mellett automatikus hibajelzés kapható
nem megfelelő állapot esetén. A potenciális tartószerkezeti problémák korai felismerésével a későbbi, komolyabb károsodások megelőzhetők, még azok bekövetkezte előtt. Annak ellenére, hogy több hazai hídon
jelenleg is van monitoring rendszer, a mért adatok nyers formában gyakran feldolgozatlanok maradnak, így
a híd állapota pusztán ezek alapján kevésbé becsülhető meg. A célunk az volt, hogy a mért nyers monitoring
adatokat digitális iker és mesterséges intelligencia alapú eszközök alkalmazásával, valós időben feldolgozzuk, és a híd statikai állapotának jellemzésére alkalmas adatokká alakítsuk, ilyen módon lehetővé téve a
szerkezettel kapcsolatos, potenciális problémák időben történő felismerését. A kifejlesztett eljárás alapjait
egy meglévő, magyarországi vasbeton szekrény keresztmetszetű közúti híd példáján keresztül mutatjuk be.
A választott híd felszerkezet statikai viselkedésének numerikus szimulációjához és a megfelelőségi feltételek ellenőrzéséhez a digitális iker (DI) technológiát alkalmaztuk. Az igénybevételek és alakváltozások
meghatározását, valamint a teherbírási (ULS) és használhatósági (SLS) feltételek ellenőrzését egy validált
3D-s végeselemes modellen (VEM) végeztük el. Monte Carlo-szimulációval különböző forgalmi terheket
generáltunk, és minden egyes teherelrendezés esetén meghatároztuk a híd kihasználtságát különböző ULS
és SLS határállapotokban, különös tekintettel a feszültségekre, a lehajlásra és a repedéstágasságra. A numerikus modellben a tényleges hídon elhelyezett szenzoroknak megfelelő helyeken az adott szenzor által
mérhető fizikai jellemzőket (pl. nyúlások) is rögzítettük minden egyes futtatás során. Ilyen módon két adathalmazt kaptunk, amelyek közül az egyik a virtuális híd statikai állapotát (kihasználtságok ULS és SLS
állapotokban), a másik a – valós hídon lévő szenzoroknak megfelelő – virtuális monitoring pontokban
egyidejűleg “mérhető” mennyiségeket tartalmazta. A két adathalmaz közötti kapcsolatot mesterséges intelligencia (MI) alkalmazás, azon belül a mesterséges neurális hálózatok (ANN) segítségével határoztuk meg.
Ezen meghatározott összefüggés alapján a tényleges hídon mért monitoring adatok valós időben feldolgozhatók és meghatározhatók a híd statikai állapotára (ULS és SLS kihasználtságok) vonatkozó számszerű
információk, ezzel segítve a szerkezet állapotának megítélését, valamint az állapottal és a karbantartási
igényekkel kapcsolatos előrejelzések készítését.
Rigid inclusions altalajjavítás tervezése és modellezése
Authors: Lôdör Kristóf , Móczár Balázs
Published: February 2025

Az elmúlt évtizedekben a fejlődő és szerteágazó kivitelezői technológiáknak köszönhetően a talajjavítási
eljárások versenyképes és gazdaságos alternatívát nyújtanak a hagyományos mélyalapozásokhoz képest az
altalaj teherbírásának növelésére, ezzel együtt képesek hatékonyan csökkenteni a szerkezetek alakváltozásait. Magyarországon az egyik legelterjedtebb altalajerősítési mód a rigid inclusions altajjavítás, amelynek
vizsgálata a rendszert alkotó szerkezeti elemek összetett viselkedése miatt nagy kihívást jelent a tervező
mérnökök számára. Nincs kiforrott, egyszerűsített méretezési eljárás, így szinte minden esetben célszerű
térbeli véges elemes modellezést készíteni az alakváltozások pontos meghatározásának érdekében, ugyanis
a legtöbbek által alkalmazott egyszerűsített numerikus modellezésekkel, vagy analitikus számítási módszerekkel nem érhető el gazdaságos tervezés. Az alapozási rendszer komplex viselkedése ellenére megfelelően
felállított talajfizikai modellparaméterekkel és szerkezeti modellgeometriával térbeli szimulációk segítségével lekövethetők annak alakváltozásai és igénybevételei.
Pengembangan Produk Alat Pengayak Pasir Secara Manual Dengan Metode Design For Manufacture and Assembly (DFMA)
Authors: SEMNASTI Akmal Suryadi , SEMNASTI Iffad Rakhmanhuda , SEMNASTI Dwi Sukma Donoriyanto
Published: February 2025

Di zaman yang serba modern ini, sudah banyak alat pengayak pasir inovasi-inovasi baru yang diciptakan untuk memudahkan penggunanya dalam aktivitas sehari-hari. Akan tetapi, banyak produsen pengayak pasir yang fokus tertuju kepada produk yang efektif dan efisien. Banyak pekerja bangunan yang mengalami ke capekan dan ketidak nyamanan yang membutuhkan inovasi produk lebih dari pengayak pasir saat ini. Sementara itu pada saat ini tidak ada alat pengayak pasir yang efektif dan efisien dengan harga yang terjangkau. Pengayak pasir ini juga dirancang untuk mengurangi jumlah tenaga kerja, sehingga produk ini memiliki nilai tambah di masyarakat. Untuk mewujudkan tujuan itu digunakan metode Design For Manufacturing And Assembly (DFMA). Design For Manufacturing And Assembly (DFMA) adalah suatu metode untuk perancangan dan pengembangan produk. Design For Manufacturing And Assembly (DFMA) juga didefinisikan oleh sebagai suatu metode terstuktur untuk melakukan perancangan dan pengembangan produk sesuai yang diinginkan oleh konsumen serta mengevaluasi secara sistematis kapabilitas suatu produk atau jasa untuk memenuhi kebutuhan konsumen dan didapat hasil pengembangan produk menjadi lebih efektif dalam hal efisiensi, efektivitas, dan reliabilitas.
Comparative experience in the implementation of instruments Regional policy instruments aimed at reducing differences in the levels of economic development and incomes of the population
Authors:   Market Economy Institute of RAS, Usmanov Daler I. ,   Financial University under the Government of the Russian Federation, Anishchenko Alesya N. ,   Market Economy Institute of RAS
Published: February 2025

The article is devoted to the analysis of the world experience in the implementation of regional policy instruments aimed at reducing differences in the levels of economic development and incomes of the population in the context of inclusive development of various integration associations. Studies by Russian and foreign scientists on global inequality, integration/disintegration processes, economic activity and international trade in general, give grounds to formulate a number of methodological approaches to determining the impact of globalization processes on the formation of effective mechanisms to promote the development of national economies of integration associations in order to ensure joint economic development. It is more correct to speak not so much about joint economic development as about inclusive economic development, which includes mechanisms of convergence of different-level interaction. It should be noted that globalization processes not only lead to changes in the importance of the centers of the world economy, but also cause significant shifts in the national economies, which raises questions about the modeling of sustainable and balanced spatial development of integration associations, reducing their differences in the level of economic development and income of the population.
Peculiarities of formation and development market economy of Japan
Authors:   Financial University under the Government of the Russian Federation, Usmanov Daler I.
Published: February 2025

It is impossible to imagine the modern world economic system without the rapidly developing information-industrialized countries of Southeast Asia. The formation and development of this region is inextricably linked with the economy of Japan. The article presents the results of retrospective analysis of the role, structure, models and main stages of formation and development of the market economy of the “Rising Sun” country (stage 1 - “Japanese Economic Miracle” (1955-1980), stage 2 - “Stagnation” (1986-2010), stage 3 - “Restoration Growth” (2010-present).
In general, Japan's economy is focused mainly on technology-intensive industries, maintaining its position as a leader in innovation. At the same time, the country's population is aging, raising concerns about the future of the labor force and social security systems. The results achieved are undoubted competitive advantages of the new economic system development track, which is not without contradictions and new challenges.
Digitalization of quality control of medical care in public medical organizations
Authors:   Ministry of Health of the Moscow Region, Sertakova Oksana V. , Kustov Yevgeniy V. ,   Ministry of Health of the Moscow Region
Published: February 2025

The article presents data from a survey of employees of state medical organizations in the Moscow region. These data show that, in general, health care workers are aware of the availability and functionality of modern health information systems. It is proposed to use medical information systems for the purpose of digitalization and automation of the process of internal and departmental quality control of medical care in state medical organizations of the Moscow region. A schematic diagram has been developed for the digitization of control processes according to quality criteria, which are named in the regulations of the Russian Ministry of Health. The continuity and continuity of the control process at the organizational, departmental and state level is shown, which is ensured by digitalization and automatic generation of the required reporting. In addition, it is shown that digitalization and automation of the process will help accelerate the transition from quality control of medical care to quality management in public medical organizations of the Moscow region.
The essence, modern features and general model of socio-economic transformation
Authors:   Market Economy Institute of RAS, Salikhov Boris V. , Salikhova Irina S. ,   Market Economy Institute of RAS,   Moscow University named after S.Yu. Witte
Published: February 2025

The article examines the qualitative integrity and dialectical interrelation of the phenomena of transformation and development, and also defines the essence of transformation as a process of creating a new form. Within the framework of the methodology of the systemic paradigm, the modern specificity of socio-economic transformation is revealed as a purposeful process of transforming socio-economic relations in order to create their new model, the basis and criterion of which is a certain level and quality of life. In the unity and interrelation of the subject, object, project, environmental and process subsystems, a political economic mechanism is proposed for the formation of a critical subject of socio-economic transformation in the form of a rule of law (within the framework of methodological socioindividualism, where a person acts simultaneously as an individual and as a member of society). The imperative of formation and continuous improvement of human capital (managerial, industrial, social, cognitive, coordination, etc.) relevant to the requirements of the target functional of socio-economic transformation is substantiated. A general scheme has been developed to increase the effectiveness of this transformation in conditions of increasing complexity.
Econometric forecast of the Russian economy growth for 2024 under increasing external sanctions pressure
Authors:   Central Economics and Mathematics Institute, Russian Academy of Sciences, Afanasiev Anton А. ,   Financial University under the Government of the Russian Federation, Ponomareva Olga S. ,   Central Economics and Mathematics Institute, Russian Academy of Sciences
Published: February 2025

Under increasing external sanctions pressure on the Russian economy from governments of Western countries that do not agree with Russia's special military operation in Ukraine, based on an econometric study of the macroeconomic production function, we present the most optimistic (of all known to us) forecasts of Russian economy growth rate for 2024 in amount of 5.4–5.5%. This values are the highest in the last 15 years and they are provided by an increase in the world price of Russian oil, an increase in the use of production capacities in industry, and the restoration of production in the oil and gas complex.
Искушение Лейбницем: почему субъект политического действия заблудился в лабиринтах неомонадологии?
Authors: Горяинов О.
Published: February 2025

В статье ставится вопрос о субъекте политического действия в контексте современной рецепции метафизики Готфрида Вильгельма Лейбница. Обзор работ современных философов, опирающихся на Лейбница, позволяет показать, что вопрос о таком субъекте последовательно обходится ими стороной. Чтобы прояснить последствия такого уклонения от вопроса о субъекте для различных версий неомонадологии, в работе проясняется проблематичность понимания субъекта по аналогии с монадами Лейбница. Анализ текстов Лейбница помогает указать на особую роль тела (материи), что влечет за собой постановку проблемы онтологического статуса отдельных тел. Для решения этой проблемы предлагается анализ понятия «субстанциальной связи» (vinculum substantiale) и его роли в системе Лейбница. Анализ «субстанциальной связи» позволяет показать, что построение на основе монадологии когерентной теории субъекта (и, в частности, субъекта политического действия) является невозможным. Для развития и закрепления этого тезиса в финальной части статьи рассматривается работа Джорджо Агамбена, в которой проявляются имплицитно присущие проекту монадологии апории.
Central Role in Social Interaction and Maintenance of Local Culture in the Widal Language Heritage of Sukabumi City
Authors: Muhamad Guntur Muntaha  , Moh.Dulkiah  , Chisa Belinda Harahap
Published: February 2025

Abstrak
Penelitian ini mengungkap fenomena budaya Indonesia melalui bahasa Widal Sukabumi di Tipar Kota Sukabumi, Jawa Barat, dengan menyoroti peran bahasa ini dalam interaksi sosial dan budaya lokal. Penelitian ini bertujuan untuk mengungkap peran bahasa Widal dalam menjaga budaya lokal, melacak pola interaksi sosial di masyarakat Tipar Sukabumi, dan mengidentifikasi jejak budaya Indonesia yang tercermin dalam struktur kebahasaan Widal Sukabumi.Metode kualitatif digunakan dengan wawancara penutur asli bahasa Widal, kajian literatur, dan video didokumentasikan sebagai sumber data. Hasil penelitian menunjukkan bahwa bahasa Widal dibentuk sebagai bahasa sandi pada era Hindia-Belanda. Struktur bahasa ini mencerminkan jejak budaya nusantara dengan kosa kata lokal dan ekspresi tradisional. Bahasa Widal tidak hanya sebagai alat komunikasi, tetapi juga warisan budaya yang memperkuat solidaritas masyarakat. Keunikan pola interaksi di Tipar menciptakan struktur sosial karena bahasa Widal. Implikasi penelitian ini meningkatkan pemahaman tentang peran bahasa Widal sebagai warisan linguistik dan alat untuk mempertahankan interaksi sosial.
 
Kata Kunci : Bahasa Widal Sukabumi,Interaksi sosial,Warisan linguistik
KRISIS REGENERASI PENGRAJIN TENUN DI DESA TROSO
Authors: Azyu Saffana , Wijaya Atika
Published: February 2025

Abstrak
Tenun Troso merupakan warisan budaya lokal Indonesia yang memiliki nilai estetika dan historis tinggi serta menjadi bagian penting dalam kehidupan sosial, budaya, dan ekonomi masyarakat Desa Troso. Namun, tradisi ini menghadapi tantangan berupa krisis regenerasi pengrajin. Tujuan dari penelitian ialah untuk menjelaskan faktor-faktor yang menyebabkan berkurangnya minat generasi muda terhadap profesi pengrajin tenun di Desa Troso serta dampak yang terjadi. Metode penelitian yang digunakan adalah jenis penelitian deskriptif dengan pendekatan kualitatif. Subjek penelitian ini ialah pengrajin tenun Troso. Pemilihan informan dilakukan dengan menggunakan teknik purposive sampling. Teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Analisis data dilakukan dengan mengikuti model Miles dan Huberman yang meliputi tiga tahap, yaitu reduksi data, penyajian data, serta penarikan kesimpulan. Peneliti menggunakan teori pilihan rasional oleh James S. Coleman untuk menganalisis permasalahan dalam penelitian ini. Hasil penelitian menunjukkan bahwa faktor-faktor yang menyebabkan krisis regenerasi ini adalah munculnya alternatif pekerjaan lain, perubahan pola pikir generasi muda, minimnya dukungan keluarga, serta menenun dianggap rumit dan membutuhkan waktu lama untuk menguasainya. Adapun dampak dari krisis ini meliputi penurunan jumlah tenaga kerja terampil, serta ancaman punahnya tradisi tenun Troso. Dengan memanfaatkan temuan dalam penelitian ini, maka diperlukan strategi untuk menciptakan keseimbangan antara melestarikan tradisi dan memenuhi kebutuhan ekonomi serta perkembangan zaman.
 
Kata Kunci : Generasi Muda, Krisis, Regenerasi, Tenun Troso, Tradisi
Pengaruh Quick Ratio (QR), Debt To Assets Ratio (DAR) Dan Earning Per Share (EPS) Terhadap Return Saham Perusahaan Manufaktur Subsektor Otomotif Dan Komponen Yang Terdaftar Di BEI
Authors: Andriani Dian Ayu , Batubara Zulfa Khairina , Fhitri Nisfu , Sinaga Dandy Gunawan
Published: February 2025

This study aims to determine whether there is an Influence of Quick Ratio, Debt to Assets Ratio and Earning Per Share on Stock Returns of Automotive and Component Manufacturing Companies Listed on the Indonesia Stock Exchange. The population in this study is the Automotive and Component Manufacturing Companies Listed on the Indonesia Stock Exchange. The sample taken using Purposive Sampling. So that 40 observations were obtained as samples. Based on the results of the study, it can be concluded that partially Quick Ratio and Earning Per Share have an effect on Stock Returns. While Debt to Assets Ratio does not affect Stock Returns. Simultaneously Quick Ratio, Debt to Assets Ratio and Earning Per Share have an effect on Stock Returns of Automotive and Component Manufacturing Companies Listed on the Indonesia Stock Exchange. The results of this study indicate that Quick Ratio (QR), Debt to Assets Ratio (DAR) and Earning Per Share (EPS) simultaneously or together are able to provide a significant influence on Stock Returns in the Automotive and Component Manufacturing Subsectors Listed on the Indonesia Stock Exchange.
Kirjojen monitahoinen elämä
Authors: Riikonen H. K.
Published: February 2025

Kirjallisuusarvostelu teoksesta Heli Rantala, Jukka Sarjala, Janne Tunturi, Ulla Ijäs & Heidi Hakkarainen, Kirjojen kaipuu. Kirjakulttuuria 1800-luvun alun Suomessa. Helsinki: Gaudeamus, 2024.
IMPLEMENTASI PROGRAM PEMBERIAN MAKANAN TAMBAHAN BAGI ANAK YANG BERESIKO STUNTING
Authors: Dwi Mayla Jesika , Isabella Isabella , Adi Putra Dwiki
Published: February 2025

This research examines the implementation of a supplementary feeding program (PMT) for children at risk of stunting in Seberang Ulu 1 District, using Edward III's Implementation Theory, which addresses communication, resources, disposition, and bureaucratic structure. A qualitative case study approach was used, involving detailed interviews with health workers, posyandu cadres, and parents, alongside field observations and document analysis. The study finds that human resources, such as health instructors and posyandu cadres, are effectively utilized, and community engagement is high with mostly positive feedback. However, there is a small group of individuals who do not fully grasp the program’s benefits, highlighting a need for better public education. Overall, the program is operating effectively, though it faces challenges including limited budget, insufficient equipment, and some bureaucratic inefficiencies. To enhance the program’s impact, recommendations include improving resource allocation, streamlining bureaucratic processes, and increasing public education efforts to ensure a broader understanding and participation.
KONSEP E-DEMOCRACY PADA TATA KELOLA PEMERINTAHAN: STUDI KASUS PENERAPAN APLIKASI TANGERANG LIVE DALAM MEMBUKA PARTISIPASI PUBLIK
Authors: Linggar Vandito Revo , Paramesti Artanti , Ali Vardan Aminudin Muhamad , Nurdin Nurdin
Published: February 2025

In the context of the Tangerang city government, the issue of public services and participation is still a problem in its implementation. There are several aspects related to services that must be improved and streamlined, such as licensing and investment services, education, agriculture and social services, especially service counters whose procedures and costs are not clear, hence the Tangerang Live application was created. The method used in this research is descriptive qualitative to provide a factual explanation of the facts that do exist in the field. The results of the survey conducted by the Tangerang City Information and Communication Office in 2023 obtained points of 80.87, indicating that the public was quite satisfied with the performance of the Tangerang Live application because it received a good indicator. In addition, the Tangerang Live application also succeeded in resolving 99.73% of the complaints made in the LAKSA feature. Thus, Tangerang Live has fulfilled the concept of e-government and increased participation through the available features
Diastolic dysfunction of the left ventricle in HIV-infected patients, clinical and prognostic relationships
Authors: Goryacheva O. G.
Published: February 2025

Diastolic dysfunction in HIV-infected patients is a common problem, the pathway of which is based on chronic low-intensity inflammation, and whose consequences are associated with progression of chronic heart failure (CHF) and death.

   The aim of the study was to evaluate clinical, echocardiographic and laboratory data of patients with diastolic left ventricular myocardial dysfunction infected with HIV and to present new prognostic relationships.

   Within the framework of a one-stage, screening, clinical study in the conditions of a multidisciplinary clinic, 240 patients with HIV infection were examined, and 136 of them showed signs of diastolic dysfunction. The development of diastolic dysfunction in HIV-infected patients is a factor provoking the development and progression of CVD, ventricular rhythm disturbances, ischemic heart disease, and anemia. Diastolic dysfunction in HIV-infected patients increases the risks of death within 2 years by 1.46 times. Increase of NT-proBNP concentration in plasma of HIV-infected patients ≥ 185.7 pg/mL is associated with the development of diastolic dysfunction in them.
Clinical safety of the usage of materials for implantation surgery based on titanium and its alloys according to the biocompatibility indexes
Authors: Dolgalev Al. Al. , Vorobyov M. S. , Prokopenko N. A. , Choniashvili D. Z. , Gezuev G. K. , Avanisyan V. M. , Piskov S. I. , Rzhepakovsky I. V.
Published: February 2025

Biocompatibility is one of the most important characteristics of materials for implantation. It has been scientifically confirmed that the physical and chemical properties of the surface of metal implants or their elements can have an impact on clinical safety. The structure of the material (porosity, smoothness, geometry) can influence its incorporation into surrounding tissues. This requires conducting experiments with a longer contact interval of the tested materials under in vivo conditions.
KANSER HÜCRELERİNDE ER STRESİ VE OTOFAJİK YOLAKLARDAKİ GENLERİN EPİGENETİK DEĞİŞİKLİKLERİNİN ARAŞTIRILMASI
Authors: Özgen Nazmi , Yüksel Şengül
Published: February 2025

Post translasyonel modifikasyonların gerçekleştiği endoplazmik retikulumda (ER) işlenmiş protein yükü ile protein katlanma kapasitesi arasındaki dengenin bozulması sonucu, adaptif ER stresi oluşur ve otofajinin aktif olması beklenir. ER stresi ve otofajik bozuklukların kanser ile ilişkisi belirsizliğini korumaktadır. Bu çalışmada çeşitli kanser hücrelerinde bu yolaklardaki anahtar genlerdeki metilasyon değişikliklerinin araştırılması amaçlanmıştır. Çalışmada çeşitli kanser hücrelerinde (HepG2, MCF-7) ve sağlıklı hücrelerdeki (MCF-10A) ilgili genlerin metilasyon düzeyleri RT-PZR tekniği ile araştırıldı. Çalışmamızda MCF7 hücrelerinde ER stresi genlerinden MAP3K5, ATF6 ve MAOA’nin DNA metilasyon düzeylerinin anlamlı şekilde azaldığı XBP1 ve EIF2AK3 genlerinde ise arttığı belirlendi. HEPG2 hücrelerinde ise MAP3K5, EIF2AK3 ve MAOA genlerinde hipometilasyon saptandı. Otofaji yolağı genlerinden ise sadece GBA geninde her iki hücrede anlamlı hipometilasyon olduğu belirlendi. Bu sonuçlarla, kanser hücrelerinde ER stresi ve otofajik yolaklardaki çoğu protein genlerinin epigenetik olarak aktivitelerinin değiştirildiği böylece hücrelerin transformasyon sürecini hızlandırıldığı söyleyebiliriz.
INVESTIGATION OF PERCEIVED STRESS LEVELS AND MOTIVATION TO PARTICIPATE IN PHYSICAL ACTIVITY IN STUDENTS OF FACULTY OF HEALTH SCIENCES
Authors: Yılmaz Ramazan Cihad , Keleş İsmail , Perçin Alper
Published: February 2025

This study aimed to investigate the perceived stress level and motivation to participate in physical activity among students of the Faculty of Health Sciences. In this descriptive, relational and cross-sectional study, 252 students studying at the Faculty of Health Sciences, Iğdır University, were included in the study determined by stratified sampling method. While the total perceived stress score of the students of the Faculty of Health Sciences was at a moderate level, their motivation to participate in physical activity scores were found to be at a high level. A weak negative correlation was observed between the mean scores of the students' Physical Activity Participation Motivation Scale and the Perceived Stress Scale (r: -0.228, p
THE IMPACT OF SMARTPHONE ADDICTION ON EMPATHY AMONG MEDICAL STUDENTS
Authors: Cansel Neslihan , Avcı Elif Beyza , Tutal Büşra , Alaca Fatma Zehra , Ghaffari Mobin , Kumaşoğlu Gamze , Çitil Melike Sena , Küçükbiltekin Sema , Taner Feyza Nur , Balıkçı Çiçek İpek
Published: February 2025

Smartphone addiction has become an increasing significant public health issue. This study has investigated the relationship between smartphone addiction, and empathy levels, and demographic variables among medical students. As a cross-sectional study, the research has been conducted with 261 medical students educating in İnönü University Medical Faculty between 21.03.2022-31.03.2022. Participants completed a survey delivered to them via Google Forms, including questions about demographic characteristics, reasons for phone use, as well as the Smartphone Addiction Scale (SAS) and the Toronto Empathy Questionnaire (TEQ). Analyses were performed by using IBM SPSS Statistics 26.0. The students' average SAS score was 90.39±23.39, and the mean TEQ score was 52.59 ± 6.66. Approximately 33.7% of participants scored above 50% on the SAS. Smartphones were used most often to listen to music (42.5%) and least often to play games (27%). Students with higher social media use and female students scores were higher on the SAS when compared to others (p
Directive adult education by political actors
Authors: Nohl Arnd-Michael
Published: February 2025

This paper presents for discussion two empirically grounded theses. First, political actors educate adults, and second, in doing so, they use directive forms of education; that is, they expect adult members of society to adopt certain orientations. Following a theoretical discussion on the directive education concept and its relevance to public pedagogy, the methodology (discourse analysis and documentary method) is explained. Then, three approaches to directive adult education demonstrated by political actors are empirically analysed: (1) directive political education is employed by political party leaders when, in the face of a potential U-turn of their party, they try to change the core political convictions of party supporters; (2) newcomers to society are directively educated to adopt democratic role orientations; and (3) in social fields in which practices are standardised by laws but cannot sufficiently be controlled, directive education for the common good can be observed. These types of directive education used by political actors are discussed vis-à-vis the concepts of paternalism and pedagogization.
A computational immune-informatics approach to design multi-epitope vaccine against Guanarito virus targeting nucleoprotein and nucleo-capsid proteins
Authors: Haq Itazaz Ul , Ullah Najeeb , Rahiyab Muhammad , Ali Syed Shujait , Khan Ishaq , Hussain Zahid , Iqbal Arshad
Published: February 2025

The human Guanarito virus (GTOV), belongs to the order Bunyavirales and family Arenaviradae, was found in the Portuguese state of Portugal’s Guanarito municipality. Due to its seasonal occurrence, Venezuelan hemorrhagic fever was caused by severe hemorrhagic febrile sickness outbreak happened in 1989. The lack of antiviral medications or vaccines to prevent the GTOV infection means that the treatment for GTOV infection is currently uncertain; thus, the development of an efficacious vaccine is imperative. Within this research, immune-informatics approaches were utilized to develop an effective vaccine candidate to combat with GTOV infections. We retrieve the nucleo and nucleo-capsid proteins of the GTOV from the National Center for Biotechnology Information database and forecast HTL, B-cell, and CTL epitopes against these proteins using different tools. Non-allergenic and antigenic epitopes were coupled with suitable linker, like KK, GPGPG, and AAY. Furthermore, an adjuvant HMAN Beta-defensin was added to the C-terminal end of the vaccine via EAAAK linker. Using the SoluProt tool, the vaccine solubility value of 0.7951 was produced. Additionally, the vaccine was projected to have an antigenicity score of 0.929968, an immunogenicity score of -0.22436, and a non-toxic and nom-allergenic reaction. It was determined that the vaccine’s ERRAT value was 97.368%, 89.0% of residues were in the most favored region, 9.6 % were in the additional allowed zone, and 0.4% were in the generously allowed region, according to the Ramachandran plot. While the vaccine’s Z-score was calculated to be -4.8. Experimental validation is required to establish the efficacy of this vaccine, with further testing needed to demonstrate its safety and immunogenicity for treating GTOV related disorders. Overall, this study highlights the potential of computational vaccine design as a promising approach to combat GTOV infections, paving the way for future experimental validation and development of an effective therapeutic strategy
Editorial: New Sound Ecologies
Authors: Teixeira William , Smolicki Jacek
Published: February 2025

In an ever-evolving world, the field of sound studies has embarked on a transformative journey, giving rise to the concept of "New Sound Ecologies." This interdisciplinary exploration aims to discuss the dynamic and intricate relationships between sound, environment, technology, and human interaction. Within this dossier, we unravel the intricate tapestry of soundscapes and their roles in contemporary society.
Case Report: Immune checkpoint-inhibitor related myotoxicity monitoring using a comprehensive cardiothoracic MRI approach: insights from a clinical case
Authors: Boussouar Samia , Charpentier Etienne , Abbar Baptiste , Gonzalez Jesus , Similowski Thomas , Kerneis Mathieu , Allenbach Yves , Bretagne Marie , Salem Joe Elie , Redheuil Alban
Published: February 2025

Recent advances in immunotherapy have significantly improved outcomes for cancer patients. However, therapies such as immune checkpoint inhibitors (ICIs) can lead to immune-related adverse events, including potentially fatal ICI-myocarditis. The diagnosis of ICI-myocarditis is complex, and cardiac MRI plays a crucial role in identifying this condition. This report presents a novel finding of elevated muscular T1 and T2 relaxation parameters using standard CMR sequences, correlating with the clinical progression of ICI-myotoxicity affecting not only the heart but also the skeletal thoracic muscles and the diaphragm. Identifying diaphragm involvement in these patients is particularly important, as it may result in respiratory failure. MRI has shown significant potential in assessing diaphragmatic function, as well as detecting tissue damage and edema, while also monitoring their evolution over time. This comprehensive, imaging-based approach could guide treatment decisions, including the use of corticosteroids and immunosuppressive therapies. Combining functional and non-invasive tissue assessments in a single MRI examination may enhance early diagnosis and improve the management of patients undergoing ICI therapy.
Ecological security pattern construction based on landscape ecological risk assessment in the Yellow River basin
Authors: Yan Jixuan , Li Jie , Yao Xiangdong , Li Qiang , Zheng Zhiqin , Li Guang , Qi Guangping , Ma Weiwei , Song Miao , Gao Pengcheng
Published: February 2025

The Yellow River Basin is one of the most ecologically fragile zones in China. Landscape ecological risk assessment and ecological security pattern construction are effective ways to find out and solve the problems of the ecological environment in this region. In this study, based on LUCC and driving factor data, we evaluated the spatial distribution characteristics of landscape ecological risk from the grid scale using the ecological risk index (ERI) and minimum cumulative resistance (MCR) models, especially proposing a new method for constructing the ecological security pattern from the perspective of landscape ecological risk assessment and finally forming an ecological security pattern network composed of points, lines, and surfaces. The results indicated that the ecological risk of the Yellow River basin showed a spatial distribution pattern of “High in southwest and northwest, low in other regions.” The middle–low level ecological risk accounted for more than 86% of the total area. The study has formed an ecological security pattern network consisting of 12 core ecological sources, 92 ecological nodes, 12 key corridors, 16 auxiliary corridors, and 4 different controlled areas. According to these study findings, we provide ecological protection strategies that strengthen the ecological source conservation, attaching importance to the construction of ecological corridor, increasing the restoration of ecological nodes, and carrying out the zoning regulation. This study will provide a new insight for the construction of the ecological security pattern network based on the results of landscape ecological risk assessment.
Does government data openness have a green effect? an examination from the perspective of green innovation
Authors: Wang Jingyuan , Chen Yan , Luo Qingfeng
Published: February 2025

Firms’ green R&D and innovation directly impact the national economy’s green and high-quality development. However, data resources play a significant role in altering traditional development models and promoting sustainable economic growth. Government data openness (GDO) offers a vital opportunity for the widespread transmission of data value. Existing literature has not yet examined whether GDO can intrinsically affect the green R&D and innovation of micro-level firms. In this study, we examine the impact of GDO on corporate green innovation using data from A-share industrial listed companies in China spanning 2007–2022 and employing the difference-in-differences (DID) method. The results indicate that GDO significantly promotes corporate green innovation. Mechanism tests reveal that GDO fosters corporate green innovation through channels such as enhancing corporate risk-taking, alleviating financing constraints, and optimizing the business environment. Further examination shows that improvements in the quality of GDO significantly enhance corporate green innovation. Moreover, the green effect of GDO is comprehensive and does not vary with the classification of green innovation types. According to the heterogeneity analysis, when management’s green cognition is higher, the firm is younger, environmental regulations are more stringent, and intellectual property is less protected, the green effect of GDO is more noticeable. This paper provides insights for promoting high-quality GDO, advancing green innovation and development in emerging market countries.
Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review
Authors: Gu Yixin , Xuan Tingting , Li Pankui , Zhou Jing , Wang Zhenhai
Published: February 2025

Metabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma. Mental and behavioral abnormalities are prevalent manifestations, accompanied by cognitive impairment, movement disorders, seizures, and other associated symptoms. In this report, we present the case of a young female patient who presented with abnormal mental behavior, seizures, and disturbances of consciousness. A cell-based assay (CBA) showed positive IgG metabotropic glutamate receptor 5 in both her serum and cerebrospinal fluid (CSF), as well as positive IgG N-methyl-D-aspartate receptor (NMDAR) in both her serum and CSF. She was diagnosed with mGluR5 overlapping NMDAR antibody encephalitis and received high-dose intravenous methylprednisolone pulse therapy and immunoglobulin therapy. Tumor screening suggested the presence of bilateral ovarian teratoma. However, unfortunately the prognosis was extremely poor. Clinical results suggested that patients with mGluR5-Abs mostly have good prognoses, excepting our case.
Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease
Authors: Fu Jiao , Wang RuoXuan , He JiHui , Liu XiaoJing , Wang XinXin , Yao JuMing , Liu Ye , Ran ChongZhao , Ye QingSong , He Yan
Published: February 2025

Microglia, the resident immune cells of the central nervous system, continuously monitor the brain’s microenvironment through their array of specific receptors. Once brain function is altered, microglia are recruited to specific sites to perform their immune functions, including phagocytosis of misfolded proteins, cellular debris, and apoptotic cells to maintain homeostasis. When toxic substances are overproduced, microglia are over-activated to produce large amounts of pro-inflammatory cytokines, which induce chronic inflammatory responses and lead to neurotoxicity. Additionally, microglia can also monitor and protect neuronal function through microglia-neuron crosstalk. Microglia receptors are important mediators for microglia to receive external stimuli, regulate the functional state of microglia, and transmit signals between cells. In this paper, we first review the role of microglia-expressed receptors in the pathogenesis and treatment of Alzheimer’s disease; moreover, we emphasize the complexity of targeting microglia for therapeutic interventions in neurodegenerative disorders to inform the discovery of new biomarkers and the development of innovative therapeutics
The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases
Authors: Deng Chunyan , Chen Dongyan , Yang Liang , Zhang Yubiao , Jin Cheng , Li Yue , Lin Qihong , Luo Mingjing , Zheng Ruihao , Huang Baozhen , Liu Sixi
Published: February 2025

The cGAS-STING pathway is essential in innate immunity, especially in antiviral responses and cellular stress management. cGAS acts as a cytoplasmic DNA sensor by initiating the synthesis of the second messenger cyclic GMP-AMP synthase (cGAMP), which subsequently activates the STING pathway, leading to the production of type I interferons and other cytokines, as well as the activation of inflammatory mediators. Recent studies have demonstrated that ubiquitination changes closely regulate the function of the cGAS-STING pathway. Ubiquitination modifications influence the stability and activity of cGAS and STING, while also influencing the accuracy of the immune response by adjusting their degradation and signal intensity. E3 ubiquitin ligase specifically facilitates the degradation or modulates the signaling of cGAS-STING-associated proteins via ubiquitination alterations. Furthermore, the ubiquitination of the cGAS-STING pathway serves distinct functions in various cell types and engages with NF-κB, IRF3/7, autophagy, and endoplasmic reticulum stress. This ubiquitin-mediated regulation is crucial for sustaining the balance of innate immunity, while excessive or inadequate ubiquitination can result in autoimmune disorders, cancers, and viral infections. An extensive examination of the ubiquitination process within the cGAS-STING pathway elucidates its specific regulatory mechanisms in innate immunity and identifies novel targets for the intervention of associated diseases.