bluuebunny/crossref_metadata_2025 huggingface dataset:
REHABILITASI PENYALAHGUNAAN NARKOBA UNTUK REMAJA DI BANJARBARU
Authors: Machfuyana Dhea Aghnia Putri , Andini Dila Nadya
Published: April 2024

Social Rehabilitation of narcotics abuse for adolescents In Banjarbaru is an institution which takes care and maintains adolescents patients who abuse narcotics to recover from their addiction. Social Rehabilitation Design is due to the large number of adolescents who use drugs and there are no special rehabilitation facilities for them yet. Issues raised in this report is how to create the design of social rehabilitation with outer space and inner space that can help the healing process. The method used to solve the issues using a healing environment. From these data, the healing environment concept emerged to create the design of outer space and inner space that can help in healing.
BENGKEL MODIFIKASI CUSTOM DI KOTA BANJARMASIN
Authors: Setiawan Eko , Heldiansyah J.C
Published: April 2024

The development in the automotive world is increasing every year, automotive manufacturers, especially motorcycles, compete to make and issue types and brands with the latest technology innovations. This encourages modification lovers to create and create modifications. South Kalimantan has considerable potential in the automotive field, especially custom modification workshops, the problem is the lack of complete workshops and facilities in one workshop, especially in the city of Banjarmasin. Custom modification workshop in Banjarmasin is very small in number, in addition it also has many shortcomings in terms of facilities and building characteristics. To answer these problems a custom modification workshop design is needed that has complete facilities in one place and has the characteristics of a modification workshop building in order to provide comfort and convenience for its visitors. The problem solving method applied is the Metaphor Architecture method, which later the metaphorical elements will be implemented in the form and space of the building. The design concept applies the concept of a custom identity motorcycle where the results of the custom modification workshop design consist of several characteristics and characteristics of a custom motorbike.
SANGGRALOKA PEGUNUNGAN KAWASAN PANTAI GEDAMBAAN KOTABARU KALIMANTAN SELATAN
Authors: Irhammi Muhammad , Nurfansyah Nurfansyah
Published: April 2024

Resorts in general, are tourism objects that utilize the natural potential that is sensitive to the environment, which is an architectural product that is environmentally friendly and sustainable with the surrounding environment. One of the tourist areas in South Kalimantan that has exotic natural potential is Kotabaru Regency. The beach and the mountains are the tourism places of Kotabaru Regency which are the main icons. The resort is one of the developing tourism in Indonesia, especially in areas with beautiful mountains and beaches. From this phenomenon, an idea emerged to present a resort that could exploit the natural potential in the mountainous area of ​​Kotabaru Regency to create a resort that can meet the needs of tourists, Contextual concept is used.
Kemampuan Literasi Numerasi: Materi, Kondisi Siswa, dan Pendekatan Pembelajarannya
Authors: Darmastuti Lintang , Meiliasari Meiliasari , Rahayu Wardani
Published: April 2024

Literasi numerasi merupakan kemampuan dasar yang menjadi prasyarat dan keterampilan hidup di abad 21. Hasil PISA 2018 menunjukkan bahwa kemampuan literasi numerasi siswa SMP belum memenuhi standar rata-rata international. Tujuan penelitian ini adalah untuk mengetahui materi SMP yang berkaitan dengan komponen literasi numerasi, mengetahui kondisi kemampuan literasi numerasi siswa SMP dilihat berdasarkan indikator kemampuan literasi numerasi dan mengetahui bagaimana melatih kemampuan numerasi menggunakan contextual learning. Penelitian ini dilakukan dengan metode Systematic Literature Review (SLR). Hasil penelitian ini, yaitu 1) materi yang berkaitan dengan komponen literasi numerasi sangat beragam, diantaranya materi rasio/perbandingan, pola bilangan, persamaan linear, fungsi kuadrat, ajabar, dan geometri; 2) ditemukan beberapa siswa SMP belum memiliki kemampuan literasi numerasi yang baik; 3) kemampuan literasi numerasi siswa SMP dapat ditingkatkan melalui contextual learning yang dibantu dengan e-modul atau media lainnya.
Life Course Epidemiology of Hip Osteoarthritis in Japan
Authors: Sato Taishi , Yamate Satoshi , Utsunomiya Takeshi , Inaba Yutaka , Ike Hiroyuki , Kinoshita Koichi , Doi Kenichiro , Kawano Tsutomu , Shiomoto Kyohei , Hara Toshihiko , Sonoda Kazuhiko , Kaneuji Ayumi , Takahashi Eiji , Shimizu Tomohiro , Takahashi Daisuke , Kohno Yusuke , Kabata Tamon , Inoue Daisuke , Matsuda Shuichi , Goto Koji , Mawatari Taro , Baba Shoji , Takagi Michiaki , Ito Juji , Nakashima Yasuharu ,   the Japanese Hip OA Consortium
Published: April 2024

Background:

The incidence of developmental dysplasia of the hip (DDH) in Japanese newborns has reduced drastically following a primary prevention campaign initiated around 1972 to 1973; this perinatal education campaign promoted maintaining the hips of newborns in the naturally flexed-leg position. The purpose of the present study was to describe the life course epidemiology of hip osteoarthritis (OA) in adolescent and adult patients and to assess its association with exposure to the primary prevention campaign for DDH.

Methods:

We included new patients with hip OA diagnosed from January 1, 2022, to December 31, 2022, at 12 core hospitals (8 special-function hospitals and 4 regional medical care support hospitals). The trend in the percentage of hips with a history of DDH treatment in childhood was estimated with use of a centered moving average using the birth year of the patient. We compared the prevalence of severe subluxation (Crowe type II, III, or IV) between patients with secondary hip OA due to hip dysplasia who were born in or before 1972 and those who were born in or after 1973.

Results:

Overall, 1,095 patients (1,381 hips) were included. The mean age at the time of the survey was 63.5 years (range, 15 to 95 years). A total of 795 patients (1,019 hips; 73.8% of hips) were diagnosed with secondary OA due to hip dysplasia. Approximately 13% to 15% of hips among patients born from 1963 to 1972 had a history of DDH treatment in childhood; however, the percentage decreased among patients born in or after 1973. The prevalence of severe subluxation (Crowe type II, III, or IV) among patients born in or after 1973 was 2.4%, which was significantly less than that among patients born in or before 1972 (11.1%; odds ratio, 0.20; p < 0.001).

Conclusions:

As of 2022, secondary hip OA due to hip dysplasia is still responsible for most new cases of adolescent and adult hip OA seen in core hospitals in Japan. However, the perinatal education campaign initiated 50 years ago, which utilized a population approach and advocated for maintaining the hips of newborns in the naturally flexed-leg position, may have improved the environmental factors of DDH, as indicated by the apparently reduced need for treatment of DDH in childhood and the associated severe subluxation. This may result in a reduced need for challenging hip surgery later in life.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Glioblastoma Presenting with the Radiological Features of a Meningioma: A Case Report and Literature Review
Authors: Song Sang-Jeong , Lee Jeong-Ho , Ryu Myung-Han , Lee Min-Seok , Suh Sang-Jun , Lee Yoon-Soo , Cho Soo-Ho
Published: April 2024

Glioblastomas, which are the most common primary malignant brain tumors in adults, occasionally exhibit radiological features similar to those of other diseases. However, instances of them mimicking meningiomas are rare. This article describes a rare case of a glioblastoma presenting with radiological features similar to those of a meningioma. A 55-year-old man was admitted following 2 months of gait disturbance, mild dysarthria, and dizziness. Magnetic resonance imaging suggested an extra-axial tumor in the interhemispheric fissure exhibiting a cerebrospinal fluid cleft sign, which was indicative of a meningioma. Bifrontal craniotomy for tumor resection revealed a highly vascularized, yellowish-gray friable mass within the interhemispheric fissure. The pathological diagnosis was glioblastoma. The patient’s symptoms improved following treatment with whole-brain radiotherapy and temozolomide chemotherapy, and his condition was stable during a 5-month follow-up period. Glioblastomas may present with radiological features similar to those of meningiomas, making it challenging for physicians to establish an accurate diagnosis and effective treatment plan.
Quantitative analysis of changing hazard exposure due to community growth in the Arequipa Region of Peru
Authors: Eberle Brook , Santi Paul , Meza Pablo
Published: April 2024

The Arequipa Region in Southern Peru is vulnerable to a unique set of geologic hazards which are a function of geology, climate, tectonic setting and the conditions of population settlement and local industries. The presence and expansion of mining in the region has the potential to directly affect geologic hazards by ground disruption and indirectly affect hazards by population increase and settlement in dangerous areas. We developed a set of geologic hazard maps for 12 communities in the region and quantified changes to hazard exposure based on community expansion patterns over time periods ranging from five to 17 years. Mapped hazards include debris flow, rockfall, flood, landslide, and earthquake liquefaction. Community expansion was measured from analysis of aerial imagery where developed areas are outlined at the beginning and end of the analyzed time interval. For the twelve communities evaluated, the percent of the developed area of each community exposed to hazards remained near constant, even with growth. Small changes were noted for specific hazards: rockfall was the most common hazard to have an increase in exposure, flood and liquefaction were the most likely to have decrease in exposure, while landslides (rotational or translational soil movements) and debris flows were the most likely to have no change. The percent of developed area exposed to high and medium levels of hazards in a community tended to decrease as development expanded over time, while area exposed to low levels of hazards increased. When analyzed by community characteristics, certain characteristics were associated with higher probability of larger changes in percent area exposed to hazards: river communities as opposed to coastal or mountain communities, small communities (< 0.5 km2 area), and communities located within 1.5 km of mining areas. Communities with extreme growth rates (more than 25% area increase per year) did not show different hazard exposure than communities with slower growth rates. The interaction between community growth and geologic hazards is an important area of future research.
Study of the mechanism pathway of sulfasalazine degradation on a novel quadripartite visible-light-driven photocatalyst
Authors: Omrani Narges , Nezamzadeh-Ejhieh Alireza
Published: April 2024

A novel coupled Cu2O-CdS-BiVO4-WO3 quadripartite nanoscale catalyst was prepared and characterized by XRD, SEM-DX, x-ray mapping, and DRS techniques. Its pHpzc was also determined to be about 9. The photodegradation experiments were designed via RSM. The optimal run in the photodegradation of sulfasalazine (SSZ) included the CSSZ: 7 mg/L, pH 6.25, 30 min irradiation time, 0.45 g/L of the catalyst dose, by a catalyst with a Cu2O-CdS-BiVO4-WO3 mole ratio 3:1:1:1 under visible light illumination. The effects of the scavenging agents were also studied, and the results confirmed the critical role of superoxide in SFSZ photodegradation and the hydroxyl radicals. The photodegradation pathway obeyed the direct Z-scheme mechanism, which involved three successive binary Z-scheme components involving WO3-BiVO4, BiVO4-CdS, and CdS-Cu2O, which accumulates the photoinduced electrons in the CB-Cu2O and the holes in the VB-WO3, the more powerful reducing and oxidizing centers, respectively.
TNF-alpha Inhibitors in Organ Transplant Recipients: A Retrospective Cohort Study
Authors: Madden Christopher , Thompson Katherine G. , Smith Isabelle T , Ike Jacqueline , Halle Briana R , Ahlers Carolyn , Mosley Dominique , Grossarth Sarah , Bibee Kristin , Wheless Lee
Published: April 2024

Tumor necrosis factor-alpha inhibitors (TNFi) can be an effective treatment for organ transplant recipients (OTR) with various diseases but can increase the risk of infection and drug interactions.1 There is also a potential for acute graft rejection while on TNFi with an unclear causal relationship. Two patients experienced acute graft rejection out of sixteen in a retrospective study of kidney transplant patients on TNFi, but the rejections were deemed unlikely to be related to biologic use.4 The purpose of this larger, multicenter study was to evaluate the safety of TNFi use in OTR by assessing rates of complications in patients treated with TNFi post-transplant.
Photoelectrochemical Ni-Catalyzed Cross-Coupling of Aryl Bromides with Amine at Ultra-Low Potential
Authors: Tang Zhiyong , Wang Jinghao , Li Siyang , Yang Caoyu , Gao Huiwen , Zuo Lulu , Guo Zhiyu , Yang Pengqi , Jiang Yuheng , Li Jian , Wu Li-Zhu
Published: April 2024

Photoelectrochemical (PEC) cell is an ideal platform for organic transformation because of its green benefits and minimal energy consumption. As an emerging methodology, the reaction types of photoelecrocatalytic organic synthesis (PECOS) are limited to simple oxidation and C–H activation at current stage. Metal catalysis with superiority in construction of C(sp2)–N bonds has not been touched yet in PECOS. We introduce here a PEC method that successfully engages Ni catalysis for the mild production of aniline derivatives. Experimental and computational investigations elucidate that the addition of photoanode-generated amine radical to Ni catalyst avoids the sluggish nucleophilic attack, enabling the reaction to proceed at an ultra-low potential (–0.4 V vs. Ag/AgNO3) and preventing the overoxidation of products in conventional electrochemical synthesis. This synergistic catalysis strategy exhibits good functional group tolerance and wide substrate scope on both aryl halides and amines, by which some important natural products and pharmaceutical chemicals have been successfully modified.
Genotype by Environment Interaction Effect and Fresh Root Yield Stability of Cassava Genotypes under Contrasting Nitrogen Regimes
Authors: Mbe Joseph Okpani , Dzidzienyo Daniel , Abah Simon Peter , Njoku Damian Ndibuisi , Onyeka Joseph , Tongoona Pangirayi , Egesi Chiedozie
Published: April 2024

Nitrogen (N) is an important nutrient element needed by cassava for optimum yield and it is a vital component of nucleotides (nucleic acids), enzymes, amino acids (proteins), chlorophyll molecules and hormones, among other essential compounds required for growth and development of cassava. Nitrogen stress is a major cassava production constraint, the study aimed to examine genotype by environment interaction (GEI) effects and fresh root yield stability of 203 diverse cassava clones to identify genotypes with stable performance under low and optimum nitrogen regime across environments using AMMI and GGE biplot analysis. Experiments were conducted using augmented block design with three replications for two years in three locations in Nigeria, under low and optimum N condition. There were significant differences (p<0.001) in the genotype’s mean performances as well as significant differences (p<0.001) in the environments mean performances for all the traits measured in both nitrogen regimes. The AMMI analysis of variance showed significant effects (p<0.001) for genotypes, environments and the interactions for fresh root yield in both nitrogen regimes. The biplot analysis showed that for fresh root yield in the optimum nitrogen regime, the principal component axis 1 explained 61.88% of the total variation while the principal component axis 2 explained 19.66%, which accounted for 81.54% of the G+GE (Genotype plus and Genotype by Environment) variation. For the G+GE for fresh root yield in the low nitrogen regime, axis 1 (50.40%) and axis 2 (21.24) together accounted for a total of 71.64% of the variation. Ten genotypes were identified as the best genotypes under the optimum nitrogen regime, while eleven genotypes were the best genotypes under the low nitrogen regime. Three genotypes under optimum nitrogen regimes were high-yielding but were unstable in their fresh root yield performance across the environments and can be recommended as specifically adapted to the environments they performed best. Three other genotypes were high-yielding genotypes under low nitrogen but were highly unstable in their fresh root yield mean performance across the environments. The environments Otobi_YR1, Igbariam_YR2, and Umudike_YR1 were identified as most discriminatory amongst the test environments. The environments Umudike_YR2 and Igbariam_YR1 were identified as most representative of the test environments and can represent a mega-environment.
MutL significantly regulates the formation of biofilms in B. subtilis YT1
Authors: Zhou Huafei , Li Baoyan , Chen Min , Chen Haining , Wang Hongtao , Wang Shaoli , Luan Binghui , Liu Baoyou
Published: April 2024

As a crucial and integral adaptation for thriving in diverse habitats, whether for survival or disease prevention and control, biofilm plays a vital role for most biocontrol bacteria, such as B. subtilis , Bacillus amyloliquefaciens, and plant-growth-promoting rhizobacteria (PGPR). However, the process of biofilm formation is intricate, and its regulatory mechanism remains unclear. In this study, we discovered that the regulatory protein MutL significantly influenced biofilm formation and exhibited a diminished colonization effectiveness on rice leaves. The mutant, lacking protein MutL expression, was unable to form biofilm with normal morphology and yielded only a quarter of the biofilm weight observed in the wild type B.subtilis YT1. In a petri dish confrontation assay examining the inhibitory effects on Rhizoctonia solani, no significant differences were observed between the mutant strain and the wild type YT1. Furthermore, through GFP fluorescent labeling technology, we conducted additional colonization tests, which demonstrated that the mutant failed to colonize rice stems effectively in the presence of R. solani. We hypothesize that the negative impact on biofilm formation resulted in inadequate colonization of rice stems, this combination accounts for the poor biocontrol efficacy against rice sheath blight, but it does not affect the normal growth of the strain or other biological phenotypes.
Characterization and Swelling Analysis of Agbaja Iron Ore
Authors: OCHERI CYRIL , Eneh Chukwunonso Jeremiah , Amatanweze Kingsley Tochukwu
Published: April 2024

Characterization and swelling analysis were performed on Agbaja iron ore to determine its suitability for engineering applications. Microstructure and morphological examinations of the ore were conducted on an inverted metallurgical microscope and SEM/ XDS techniques. Thermogravimetry, Differential Thermal Analyzer, X-Ray Fluorescence, and X-Ray Diffraction were used to analyze the chemical and structural compositions of the ore. The iron ore was heated in the muffle furnace to calculate the swelling percentage. The samples were subjected to temperatures 800oC to 1000oC with an interval of 40oC and a hold time of 30mins to 130 mins with an interval of 20mins. The samples were weighed with a digital weighing balance before and after heating to keep track of their initial weight, final weight and hence, percentage swelling induced by the thermal process. After a 30 mins hold time, 3.12% swelling was obtained at 800oC as the lowest point, while 3.67% was obtained at 1000oC. However, after a hold time of 130mins, 3.93% swelling was obtained at 800oC as the lowest point, while the highest percent swelling of 5.52% were obtained at 1000oC.
Radiomic Features Based on Multi-sequence MRI Predict Immunohistochemical Biomarkers of Endometrial Cancer
Authors: Shen Liting , Chen Xiaojun , Li Lan , Zeng Yan , Yan Zhihan , Han Lu , Pan Jiangfeng , Wang Xue
Published: April 2024

Background: Different molecular or genetic information influences the clinical decisions for patients diagnosed with endometrial cancer (EC). A non-invasive, precise, and efficient preoperative evaluation method is crucial for the prognosis of patients with EC.
Purpose: The aim of this study was to construct MRI-based radiomics models to predict immunohistochemical biomarkers and assess the relationship between radiomic features and the Ki-67 proliferation rate in EC.
Material and Methods: We retrospectively analyzed 100 estrogen receptor (ER), 94 progesterone receptor (PR), 97 P53, and 98 Ki-67 immunohistochemistry cases with EC who underwent magnetic resonance imaging (MRI) between May 2012 and June 2023 prior to surgery. Radiomic features were individually extracted from T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and the apparent diffusion coefficient (ADC). Least absolute shrinkage and selection operator (LASSO) regression was employed for feature selection. And logistic regression was employed to construct radiomics models with 5-fold cross-validation. The receiver operating characteristic (ROC) curves were analyzed to evaluate the performance of the radiomics models. Finally, Pearson's correlations were utilized to explore the association between the values of selected features and the Ki-67 proliferation rate.
Results: A total of 2264 features were extracted from each patient’s MRI sequences. The selected features from the multi-sequence models were shared with or without the single sequence models. Both single sequence and multi-sequence models demonstrated good diagnostic performance, although the diagnostic performance of multi-sequence models outperformed the single sequence models. Correlation analysis showed that adc_wavelet_glszm_wavelet-HHH-SmallAreaLowGrayLevelEmphasis and t2_log_firstorder_log-sigma-2-0-mm-3D-Skewness were negatively correlated with the Ki-67 proliferation rate.
Conclusions: MRI-based radiomic features are promising predictors of immunohistochemistry and prognosis in EC.
A Cauchy Integral formula for LR-(p,q)-monogenic functions with α-weight
Authors: Du Xiaojing , Gao Long , Xie Yonghong
Published: April 2024

Firstly, some properties for LR-(p,q)-monogenic functions with α-weight valued in a universal Clifford algebra are given. Secondly, the Cauchy-Pompeiu formula for functions valued in a universal Clifford algebra is proved. Finally, a Cauchy integral formula and the Cauchy integral theorem for LR-(p,q)-monogenic functions with α-weight valued in a universal Clifford algebra are given.
MR Subject Classification: 30E20, 30E25, 45E05.
MenSCs ameliorate experimental colitis by protecting intestinal barrier integrity by inhibiting the NF-κB/Snail signaling pathway
Authors: Ruan Tao , Xue Chengxu , Han Jiaming , Cheng Fangfang , Liang Haiyan , Lin Juntang
Published: April 2024

Background: Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic recurrent nonspecific intestinal disease that are characterized by intestinal epithelial barrier dysfunction and excessive activation of the mucosal immune system. In this study, we aimed to investigate the effects and mechanisms of menstrual blood-derived stem cells(MenSCs) against colon inflammation and mucosal tissue repair.Methods:LPS-exposed human colonic epithelial cancer cell line Caco2, and HT29. Tight junction(TJ) proteins and the level of inflammatory factors were assessed by Western blot and qRT-PCR. MenSCswere co-cultured with LPS-exposed human colonic epithelial cancer cell line, HT29, dextran sulfate sodium (DSS)-induced IBD mouse models were intravenously administered MenSCs. Effects of MenSCs on intestinal inflammation, and colon barrier function were investigated. Finally, NF-κB-snail signaling pathway were assessed by western blot.Results:LPS downregulates intercellular junction proteins, and induces the production of inflammatory cytokines in intestinal epithelial cells.MenSCs mitigated DSS-induced colitis in mice, by reducing body weight loss, colonic shortening, and disease activity index scores and by inhibiting the expressions of the proinflammatory cytokines IL-1β, IL-6, and TNF-α. MenSCs increased the expression of TJ proteins, improved the destruction of tight junction (TJ) structures and reduced intestinal epithelial permeability. Furthermore, MenSCs could inhibit NF-κB p65 phosphorylation and the expression of Snail and prevent Snail nuclear localization, thereby maintaining tight and adherens junctions.Conclusions:Our data demonstrate that MenSCsalleviates gut inflammation, protects intestinal mucosal barrier by inhibiting the NF-κB /Snail signaling pathway.
Characteristics of Japanese patients with systemic sclerosis with dysphagia: a single-center study
Authors: Naganawa Tatsuaki , Hashimoto Takako , Ikeda Naomi , Takase Haruna , Dosoden Naoki , Ito Kodai , Sawada Marika , Ito Yumi , Watanabe Natsuko , Umeda Ai , Akamatsu Konomi , Kurumizawa Megumi , Nishino Jo , Fukaya Shusaku , Inamoto Yoko , Shibata Seiko , Otaka Yohei , Yasuoka Hidekata
Published: April 2024

To determine the prevalence of dysphagia and examine the association among dysphagia, components of gastrointestinal (GI) involvement and clinical features. Fifty consecutive patients with systemic sclerosis (SSc) examined by videofluoroscopic swallowing study were included. Dysphagia was identified by functional abnormalities such as aspiration and/or laryngeal penetration. Radiological findings such as the existence of residue was also evaluated. Esophageal involvement (E) and pharyngeal involvement (P) were defined by residue and gut involvement (G) was by the presence of diarrhea. Twenty-three patients (46%) had dysphagia. E was found in 96%, P in 82%, and G in 50%. Most of E had P (83%), and almost half of P had G (55%). All with G had E, and most of G was with P (88%). The E + P + G + group had younger onset, higher frequency with dysphagia, and higher UCLA GIT-2.0 compared with the E + P + group. Functional dysphagia was associated with radiological abnormalities such as pharyngeal and esophageal residue, diarrhea, and UCLA GIT-2.0 by multivariate analysis. Half of patients were affected by dysphagia. Pharyngeal involvement can be included in upper GI involvement. The emergence of pharyngeal involvement is an earlier stage than that of gut involvement, and patients with younger onset can have extended phenotype.
Aggregate morphing of self-aligining soft active disks in semi-confined geometry
Authors: Chugh Anshika , De Karmakar Soumen , Ganesh Rajaraman
Published: April 2024

We study the dependence of alignment and confinement on the aggregate morphology of self-aligning soft disks in a planer box geometry confined along y direction. We show that the wall accumulation of aggregates becomes non-uniform upon increase in alignment strength and decrease in box width. The height of these structures is found to be a non-monotonic function of alignment strength. Additionally, we identify two distinct categories of wall aggregates: layered and non-layered structures each exhibiting distinct local structural properties. For non-layered structures, local properties stay nearly constant as we move away from the boundary, while for layered structures, they increase with distance from the boundary. Our analysis shows that active pressure difference is a useful indicator for different aggregate morphologies and the peaks in the pressure curve are indicative of the average and minimum height of the structure.
Enhancing Nurse Competence in Early Recognition of Cardiotoxicity
Authors: Kolbus Jeffry , Adeola Mopelola , Luebcke Caitlin , Tipton Janelle
Published: April 2024

Objective: To assess the impact of an educational intervention on nurses perceived self-efficacy in recognizing patients exhibiting symptoms of cancer treatment-related cardiotoxicity.
Sample & Setting: The study was set in a 16-bed cardiac critical care unit (CCU) within a 462-bed hospital. The sample group was comprised of registered nurses (RNs) working on or floating to the CCU.
Methods & Variables: The study used a within-subjects design. Participants completed a pre-education survey, attended a 30-minute education intervention, and completed a post-education survey. The outcome variables were 7 self-confidence questions from the Nursing Self-Efficacy Scale for Managing Cancer Treatment-Induced Cardiotoxicity (NSS-CTC) on a 5-point Likert scale and one yes or no self-efficacy question. Descriptive statistics and paired T-tests were applied to analyze pre- and post-education surveys.
Results: The pre-and post-education comparative analysis for each of the 7 NSS-CTC self-confidence questions was statistically significant with test statistics ranging from t = 3.43 to t = 8.69 and p-values ranging from 0.0021 to less than 0.0001. All 26 RNs answered “yes” in their ability to detect symptoms of cancer therapy-related cardiotoxicity after the education.
Implications for Nursing: The lack of education for cardiac nurses against the backdrop of increasing cardiotoxicity in cancer patients showcases the essential need for cardiac nurse early symptom recognition education.
Synthesis of recommendations and evidence for managing hypertensive disorders of pregnancy in low middle-income countries: a Scoping Review
Authors: Escobar Maria Fernanda , Benitez-Díaz Nicole , Blanco-Londoño Isabella , Guevara-Calderón Lizbeth A. , Cerón-Garcés Catalina , Peña-Zárate Evelyn E. , Libreros-Peña Laura , Galindo Juan Sebastián
Published: April 2024

Background and Objectives: Hypertensive disorders of pregnancy (HDPs) remain one of the leading causes of maternal mortality globally, especially in Low- and middle-income countries (LMICs). To reduce the burden of associated morbidity and mortality, standardized prompt recognition, evaluation, and treatment have been proposed. Health disparities, barriers to access to healthcare, and shortage of resources influence these conditions. We aimed to synthesize the recommendations and literature evidence for the management of HDPs in LMICs.
Methods: A scoping review was conducted in five databases (PubMed, Web of Science, Epistemonikos, Clinical Key, and, Scielo) using MeSh terms, keywords, and Boolean connectors. We summarized the included studies according to the following categories: study design, objectives, settings, participant characteristics, eligibility criteria, interventions, assessed outcomes, and general findings.
Results: 651 articles were retrieved from the literature search in five databases. Following the selection process, 65 articles met the predefined eligibility criteria. After performing a full-text analysis, 27 articles were included. Three themes were identified from the articles reviewed: prevention of HDPs, management of HDPs (antihypertensive and non-hypertensive management) and pregnancy monitoring and follow-up. The topics were approached from the perspective of LMICs.
Conclusions: LMICs face substantial limitations and obstacles in the comprehensive management of HDPs. While management recommendations in most LMICs align with international guidelines, several factors, including limited access to crucial medications, unavailability of diagnostic tests, deficiencies in high-quality healthcare infrastructure, restrictions on continuing professional development, a shortage of trained personnel, community perceptions of preeclampsia, and outdated local clinical practice guidelines, impede the comprehensive management of patients. The development and implementation of protocols, standardized guides and intervention packages are a priority.
Electroencephalogram in cirrhotic children without clinical encephalopathy
Authors: Shahramian Iraj , Mohammadi Mohammad Hassan , Aminisefat Alireza , sabet Negar shafiei , Ataollahi Maryam , Afshari Mahdi
Published: April 2024

Introduction
Cirrhosis is one of the most common causes of hospitalization and death in children, so prevention of progressive liver diseases such as hepatic encephalopathy (HE) is critical. In addition to overt HE, subclinical hepatic encephalopathy (SHE) and mild hepatic encephalopathy (MHE) are stages of HE that can only be diagnosed by psychometric and neurophysiological tests, and with early diagnosis and treatment, daily functioning of patients will improve. Therefore, purpose of this study is determining electroencephalogram (EEG) findings in children with cirrhosis without clinical encephalopathy.
Methods
This study was conducted observationally at Amir Al Momenin Zabol Hospital, Zabol University of Medical Sciences, Iran. In this study, 50 children with cirrhosis without encephalopathy symptoms and 50 healthy children were examined for abnormal electroencephalogram findings. Finally, the data were analyzed using SPSS V22 software.
Results
The mean and standard deviation of study population age was 57.6 ± 76.17 months. Of a total of 50 children with cirrhosis, 21 (42%) had abnormal EEG findings, whereas no child in the healthy group had abnormal EEG findings. There was a significant association between abnormal EEG findings and older age (P = 0.001), underlying autoimmune hepatitis disease (P = 0.011), and abnormal (elevated) serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) .Children with cirrhosis who had abnormal EEG findings had a higher mean Pediatric End-Stage Liver Disease (PELD) score (18.1 ± 4.1) than patients with normal EEG findings (17.2 ± 3.7), but these findings was not statistically significant or remarkable ( P = 0.073). The sensitivity of EEG for predicting the severity of cirrhosis was estimated to be 70% and the specificity to be 65%.
Conclusion
The results of this study demonstrate that the higher sensitivity of EEG compared to the specificity in predicting the severity of cirrhosis indicates that EEG can be used to exclude severe cirrhosis or to screen cirrhotic patients at risk of deterioration than in confirming its diagnosis.
Refractive error and Alzheimer's disease: A bidirectional Mendelian randomization study
Authors: Fan Wenfeng , Ma Keke , Yang Caixia , Xu Yuming , Shi Changhe , Guo Li-na , Dong Xiaofang , Guo Yuanli
Published: April 2024

Background and aims:
Observational studies have shown an association between refractive error and Alzheimer's disease (AD). However, whether there is a causal relationship between them remains unclear. This study aimed to investigate the association between genetically predicted refractive error and Alzheimer's disease and vice versa.
Methods
A bidirectional Mendelian randomization (MR) study of refractive error and Alzheimer's disease from European ancestry was performed using summary statistics from Genome-Wide Association Studies. A series of sensitivity studies, such as heterogeneity tests, multiple validity tests, and leave one out analyses, were also conducted to further assess the accuracy of the MR analyses.
Results
In the forward MR analysis, no significant association was found between refractive error and Alzheimer's disease using 98 genome-wide single nucleotide polymorphisms (SNPs) as instrumental variables for refractive error (IVW: β = 0.003, 95%CI of 0.931 to 1.080, P = 0.936). However, in the reverse MR analysis, three genome-wide SNPs were used as instrumental variables for Alzheimer's disease, revealing a significant association between Alzheimer's disease and refractive error (IVW༚β = 4.616, 95%CI of 5.447 to 1876.674, P = 0.001). Moreover, the weighted median analysis yielded consistent results.
Conclusions
Our research findings suggest that refractive errors seem to be unrelated to Alzheimer's disease. Conversely, refractive errors may be downstream effects of Alzheimer's disease.
The relationship between affective leadership and the voice behavior of nurses: A cross-level moderated mediation model
Authors: Wang Qinglin , Zhang Hang , Li Yongxin , Wang Minghui
Published: April 2024

Drawing on social exchange theory, the study used multi-level structural equation model to statistically examine 167 matched surveys from leaders and subordinates. The study aimed to explore the mediating role of supervisor-subordinate Guanxibetween affective leadership and voice behavior, as well as the cross-level moderating impact of group voice climate. The findings revealed the following key points: while affective leadership showed a significant and positive association with supervisor-subordinate Guanxi, it did not directly correlate with voice behavior. On the other hand, supervisor-subordinate Guanxidemonstrated a significant and positive link with voice behavior. Moreover, our results suggested that affective leadership might impact voice behavior through the mediating effect of supervisor-subordinate Guanxi, with this indirect influence being contingent upon group voice climate. Notably, the indirect impact was more pronounced in settings characterized by a high group voice climate.
Damage Localization in Photovoltaic Solar Panels Using Impedance-Based Shm with Neural Networks
Authors: SAKHRIA Billel , HAMAIDI Brahim , DJEMANA Mohamed , BENHASSINE Naamane
Published: April 2024

The accurate fault detection and monitoring system is necessary and essential to maintain the optimal performance of the photovoltaic (PV) system, the literature on this topic has identified most of the case detection methods that focused only on the system (PV). The gap found is the main problem of the most previous studies and research and duplication of research in the detection of defects (structure and system). This paper presents the results of electromechanical impedance (EMI) analysis performed for a 36-cell silicon photovoltaic module with bonded piezoelectric transducer (PZT). Utilizing ANSYS software, a comprehensive three-dimensional coupled field finite element model is constructed, facilitating harmonic analysis in the context of high-frequency impedance analysis procedures. However, the conventional examination of electromagnetic impedances proves inadequate in offering a comprehensive understanding of damage localization. This study offers valuable perspectives on the formulation and application of a concise electromagnetic (E/M) impedance technique designed for high-frequency impedance analysis. Moreover, it underscores the inherent limitations associated with relying solely on electromagnetic impedances for accurate damage localization. This study provides useful insights into the development and implementation of the compact E/M impedance method for high-frequency impedance analysis and highlights the limitations of using EMIs for damage localization. The model's training process is undertaken using simulation data to encompass a broad spectrum of scenarios. Subsequently, its validation is executed on a photovoltaic (PV) panel model to establish its viability and demonstrate the model's practical applicability. The extreme learning machine (ELM) based algorithm has been devised to predict damage locations using data from piezoelectric sensors. The trained model demonstrated heightened predictive accuracy in comparison to alternative classification methodologies within the realm of machine learning. The outcomes underscore the superior efficacy of the ELM algorithm in defect detection, boasting an impressive overall accuracy rate of 85%.
Effect of incision location and type of fistula on postoperative urinary retention after radical surgery for anal fistula: a retrospective analysis
Authors: Li Chen , Liu Ningyuan , Huang Zichen , Wei Zijian , Li Keyi , Hou Wenxiao , Ye Sangyu , Zheng Lihua
Published: April 2024

Background
Postoperative urinary retention (POUR) refers to the postoperative symptom of bladder fullness without the ability to urinate autonomously. The etiology of POUR in proctology surgery remains unclear, and the underlying causes are multifactorial. The aim of this study was to determine the risk factors for POUR after radical surgery for anal fistula.
Methods
We retrospectively reviewed the clinical records of 511 patients who underwent radical surgery for anal fistula under general anesthesia at the China-Japan Friendship Hospital from August 2022 to December 2023. Risk factors for POUR were determined using binary logistic regression analyses.
Results
57 patients (11.2%) experienced urinary retention within 48 hours after surgery, while the majority of whom were male (84.4%). Multivariate logistic stepwise regression revealed that a history of urological disease (OR = 6.048; P < 0.001), incisions at position 1 (OR = 2.228; P = 0.046), the presence of high anal fistula (OR = 4.768; P < 0.001), a VAS score ≥ 7 (OR = 2.805; P = 0.010), and a GAD-7 score ≥ 5 (OR = 2.405; P = 0.024) were independent risk factors for POUR after radical surgery for anal fistula.
Conclusion
POUR is a common complication following radical surgery for anal fistula. Patients with urological disease or high anal fistula or incisions at position 1 are more likely to develop POUR. Surgeons should pay more attention to the surgical techniques of fistulas in the anterior rectum. Better postoperative pain and anxiety management strategies should be provided to reduce the incidence of POUR and avoid irreversible damage caused by persistent bladder overdistension.
Classification of MRI-only suspicious breast lesions: Development and validation of a nomogram combining MRI features and apparent diffusion coefficient histogram
Authors: Li Xue , Jiang Lei , Gao Jiayin , Zheng Dandan , Wang Hong , Chen Min
Published: April 2024

Purpose
We aimed to develop and validate a nomogram combining clinicoradiologic features and apparent diffusion coefficient (ADC)-based histogram parameters for MRI-only suspicious lesions.
Methods
Ninety patients who underwent breast MRI between May 2017 and August 2023 and were found to have MRI-only suspicious lesions were retrospectively included and randomly divided into training (n = 62) and validation (n = 28) cohorts. The clinical information and MRI features of each patient were reviewed and analyzed. The ADC maps of each patient were subjected to histogram analysis, and then 17 histogram parameters were extracted. Univariate and multivariate logistic regression analyses were performed to identify significant variables associated with predicting MRI-only malignant lesions, which were then included in the nomogram. The diagnostic performances of significant variables and the nomogram were evaluated and compared in terms of the area under the receiver operating characteristic (ROC) curve (AUC) and DeLong’s test.
Results
The kinetic pattern in clinicoradiologic features (P = 0.004, odds ratio [OR] = 2.268) and ADC entropy in histogram parameters (P = 0.003, OR = 6.49) were significant variables associated with the classification of MRI-only suspicious lesions. The C-index values for the nomogram combining ADC entropy and kinetic pattern were 0.820 (95% confidence interval [CI]: 0.702–0.906) for the training cohort and 0.728 (95% CI: 0.528–0.878) for the validation cohort.
Conclusions
The nomogram combining kinetic pattern and ADC entropy can be used as a simple and noninvasive tool for classifying MRI-only suspicious lesions.
Somalia’s Medical Education and Regulation: A Review of the Health Regulatory Landscape
Authors: Hassan Mulki Mukhtar , Ali Amal Naleye , Ali Ifrah , Mohamed Zeinab Omar , Abdullahi Hamza Mohamed , Ahmed Mohamed Mustaf , Mohamud Abdirahman Khalif , Adebisi Yusuff Adebayo , Okesanya Olalekan John , III Don Eliseo Lucero-Prisno
Published: April 2024

Background: Medical education and regulations are pivotal to achieving universal health coverage and Sustainable Development Goals, contributing significantly to health outcomes and public trust in the healthcare workforce. However, low- and middle-income countries, especially in sub-Saharan Africa, face challenges, such as inadequate resources, outdated curricula, and weak governance. Somalia in particular grapples with a fragmented health system and a critical shortage of skilled health professionals, exacerbated by decades of civil war and political instability.
Methods: This study employed a mixed-method approach that incorporated both qualitative and quantitative data collection and analysis. A comprehensive literature review was conducted, along with semi-structured interviews with 44 key informants, including representatives from professional health schools and officials from the Ministry of Health. Additionally, five focus group discussions were held with young professionals and an online survey was administered to students enrolled in professional health courses. The data analysis employed descriptive for quantitative data, and thematic analysis for qualitative data, guided by the HRH maturity model framework.
Results: This study identified 94 medical schools across Somalia, with a significant concentration in urban areas, particularly in Benadir. However, only 25 of these schools are internationally accredited, raising concerns about the quality of medical education. The health workforce analysis revealed a pronounced urban-rural disparity and a density of health professionals below the WHO's recommended threshold. Focus group discussions and surveys highlighted the employment challenges faced by young physicians and students' perceptions of their training and future employment opportunities.
Conclusion: The proliferation of medical schools without adequate quality control, the critical shortage and maldistribution of skilled health professionals, and the absence of a comprehensive regulatory framework are significant challenges facing Somalia's healthcare system. The establishment of the National Health Professionals' Council (NHPC) Act in 2020 marks a step towards addressing these issues. This study emphasizes the need for accreditation of medical schools, capacity building of HRH teams, and collaboration among stakeholders to improve healthcare workforce development and regulation. Addressing urban-rural disparities and combating professional misconduct are also crucial for achieving universal health coverage and improving health outcomes in Somalia.
Cross-cultural differences in gastrointestinal symptoms and sensory response in individuals with autism: A comparison of Spain and Colombia.
Authors: Rodríguez-Jiménez Tíscar , Martínez-González Agustín E. , Riaño-Hernández Diana
Published: April 2024

Purpose. Between 40 and 70% of the population with autism have been found to suffer from functional gastrointestinal disorders (FGIDs). The emergence of FGIDs is related with lower quality of life, and greater medical resources, somatization and emotional instability. There is a paucity of research available that examines gastrointestinal symptoms and sensory responses in individuals with autism in different countries and cultures. Methods. The present study analyses differences in gastrointestinal symptoms and sensory response between individuals with autism from Spain (n=65; mean age = 8.91, SD = 4.02) and Colombia (n=62; mean age = 10.16, SD = 5.31). Results. No differences were found as a function of age, sex and autism severity between Spanish and Colombian participants. More severe functional nausea and vomiting was reported by the Colombian sample when compared with the Spanish sample. Similarly, greater sensory reactivity emerged in Colombian individuals with autism relative to Spanish individuals with autism. Conclusions. Identified differences may suggest that the impact of nutritional and epigenetic factors is dependent on the cultural context. Present findings are of huge relevance to the application of treatments in different cultures based on probiotics, prebiotics and nutrition.