bluuebunny/crossref_metadata_2025 huggingface dataset:
Lidocaine as an element of multimodal analgesic therapy in major spine surgical procedures in children: a prospective, randomized, double-blind study
Authors: Batko Ilona , Kościelniak-Merak Barbara , Tomasik Przemysław J. , Kobylarz Krzysztof , Wordliczek Jerzy
Published: April 2020

Background

Introducing the principles of multimodal analgesic therapy is necessary to provide appropriate comfort for the patient after surgery. The main objective of the study was evaluating the influence of perioperative intravenous (i.v.) lidocaine infusion on postoperative morphine requirements during the first 48 h postoperatively in children undergoing major spine surgery.

Materials and methods

Prospective, randomized, double-blind study: 41 children, qualified to multilevel spine surgery, were randomly divided into two treatment groups: lidocaine and placebo (control). The lidocaine group received lidocaine as a bolus of 1.5 mg/kg over 30 minutes, followed by a continuous infusion at 1 mg/kg/h to 6 hours after surgery. The protocol of perioperative management was identical for all patients. Measurements: morphine demand, intensity of postoperative pain (the Numerical Rating Scale), oral feeding initiation time, first attempts at assuming erect position, postoperative quality of life (the Acute Short-form /SF-12/ health survey).

Results

Patient data did not differ demographically. Compared to the control group, lidocaine treatment reduced the demand for morphine during the first 24h [95% CI 0.13 (0.11-0.28) mg/kg, p = 0.0122], 48h [95% CI 0.46 (0.22-0.52) mg/kg, p = 0.0299] after surgery and entire hospitalization [95% CI 0.58 (0.19-0.78) mg/kg, p = 0.04]; postoperative pain intensity; nutritional withdrawal period [introduction of liquid diet (p = 0.024) and solid diet (p = 0.012)], and accelerated the adoption of an upright position [sitting (p = 0.048); walking (p = 0.049)]. The SF-12 generic health survey did not differ between groups before operation, 2 months and 4 years after surgery.

Conclusions

Perioperative lidocaine administration, as a part of the applied analgesic therapy regimen, may decrease postoperative opioid demand and accelerates convalescence of children undergoing major surgery.
OPTIMAL ASSET ALLOCATION FOR DC PENSION DECUMULATION WITH A VARIABLE SPENDING RULE
Authors: Forsyth Peter A. , Vetzal Kenneth R. , Westmacott Graham
Published: April 2020

We determine the optimal asset allocation to bonds and stocks using an annually recalculated virtual annuity (ARVA) spending rule for DC pension plan decumulation. Our objective function minimizes downside withdrawal variability for a given fixed value of total expected withdrawals. The optimal asset allocation is found using optimal stochastic control methods. We formulate the strategy as a solution to a Hamilton–Jacobi–Bellman (HJB) Partial Integro Differential Equation (PIDE). We impose realistic constraints on the controls (no-shorting, no-leverage, discrete rebalancing) and solve the HJB PIDEs numerically. Compared to a fixed-weight strategy which has the same expected total withdrawals, the optimal strategy has a much smaller average allocation to stocks and tends to de-risk rapidly over time. This conclusion holds in the case of a parametric model based on historical data and also in a bootstrapped market based on the historical data.
“Africa for the Africans?” – Mapmaking, Lagos, and the Colonial Archive
Authors: Adelusi-Adeluyi Ademide
Published: April 2020

In early colonial Lagos, struggles over race, place and identity were played out over ownership of land, and ended with the displacement of sections of the indigenous population. “Africa for the Africans” combines texts and maps to narrate the history of 1860s Lagos. This article demonstrates how, with Geographic Information Systems (GIS), European colonial maps can be used to analyze the significance of changing urban spatial relationships in 1860s Lagos. Though much of this analysis employs GIS, it also leans heavily on other tools for making timelines, story maps and vector diagrams. This process of creating digital representations of the past also has pedagogical applications, as these methods can be extended to the classroom for undergraduates learning about African history.
DENIAL OF HISTORY? YASUKUNI VISITS AS SIGNALING
Authors: Fujita Taisuke , Kusano Hiroki
Published: April 2020

Under what conditions would Japanese leaders visit the controversial Yasukuni Shrine and why? Previous studies have focused primarily on the domestic benefits and effects of such visits, claiming that leaders employ visits to follow their own conservative ideology and gain domestic political support. Given the harsh international criticism that tends to ensue, however, political leaders should also consider the cost and international effects of such visits. This study proposes three necessary conditions for such visits: a conservative ruling party, a government enjoying high popularity, and Japan's perception of a Chinese threat. With regard to the latter, a security threat from China has allowed Japan to use these visits as a credible signal of its resolve against China. Comparative analyses of Japanese cabinets after the mid-1980s support this argument.
PARTY COMPETITION AND IDEOLOGY IN HONG KONG: A NEW MANIFESTO CODING DATASET
Authors: Wong Mathew Y. H.
Published: April 2020

This study provides a new dataset on the ideological positions of political parties in Hong Kong, which is a hybrid regime with electoral elements. Using this dataset, the study challenges the non-ideological view of party competition in Hong Kong by identifying an ideological dimension to the elections held between 1998 and 2016. It is shown that parties do position themselves along an identifiable left–right spectrum, with shifts that can be meaningfully interpreted, and that the aggregate ideology of the electorate appears to be linked to the level of economic growth. The ideological dimension provides a novel perspective on local politics that looks beyond the dominant pro-democracy versus pro-Beijing divide while also shedding light on the recent changes underlying the latter. This study provides valuable objective data for analyzing political competition dynamics and contributes to the comparative literature by incorporating Hong Kong into the framework of the manifesto coding project.
National parks influence habitat use of lowland tapirs in adjacent private lands in the Southern Yungas of Argentina
Authors: Rivera Luis Osvaldo , Martinuzzi Sebastian , Politi Natalia , Bardavid Sofia , de Bustos Soledad , Chalukian Silvia , Lizárraga Leonidas , Radeloff Volker , Pidgeon Anna
Published: April 2020

Protected areas are cornerstones of conservation efforts worldwide. However, protected areas do not act in isolation because they are connected with surrounding, unprotected lands. Few studies have evaluated the effects of protected areas on wildlife populations inhabiting private lands in the surrounding landscapes. The lowland tapir Tapirus terrestris is the largest terrestrial mammal of the Neotropics and is categorized as Vulnerable on the IUCN Red List. It is necessary to understand the influence of landscape characteristics on the tapir's habitat use to enable effective conservation management for this species. Our objectives were to (1) determine the potential distribution of the lowland tapir's habitat in the Southern Yungas of Argentina, and (2) evaluate the role of protected areas and other covariates on tapir habitat use in adjacent private lands. We used records of lowland tapirs to model the species' potential distribution and determined habitat use with occupancy modelling. Based on the covariates found to be significant in our models, we constructed predictive maps of probability of habitat use and assessed the area of potential habitat remaining for the species. Probability of habitat use was higher in the vicinity of two national parks and small households than further away from them. We found that in 85% of the lowland tapir's potential distribution the probability of habitat use is high (> 0.5). These areas are near the three national parks in the study area. The probability of detecting lowland tapirs increased with distance to roads. We conclude that national parks play a key role in the persistence of lowland tapir populations on adjacent private lands.
A Magnetometry Survey of the Second Augustan Legionary Fortress at Lake Farm, Dorset
Authors: Stewart Dave , Cheetham Paul , Russell Miles
Published: April 2020

A magnetometry survey of the Roman fort at Lake Farm, near Wimborne Minster in Dorset, first discovered in 1959, has upgraded the status of this site to a full legionary fortress: a major base of thelegioII Augusta during the subjugation of the Durotriges and other tribes of south-west Britain. The interior layout of the fortress was identified for the first time, together with the original road and river connections, extensive areas of extramural activity and evidence for an earlier phase of the site as a marching camp.
Rationalization is a suboptimal defense mechanism associated with clinical and forensic problems
Authors: Brody Stuart , Costa Rui Miguel
Published: April 2020

Cushman argues that “rationalization is rational.” We show that there is reasonable empirical clinical and forensic psychological evidence to support viewing rationalization as a quite suboptimal defense mechanism. Rationalization has been found to be associated not only with poorer emotional development, but also with a broad range of antisocial behavior, including not only shoplifting, but also pedophilia and murder.
Evidence for the rationalisation phenomenon is exaggerated
Authors: Stafford Tom
Published: April 2020

The evidence for rationalisation, which motivates the target article, is exaggerated. Experimental evidence shows that rationalisation effects are small rather than gross and, I argue, largely silent on the pervasiveness and persistence of the phenomenon. At least some examples taken to show rationalisation also have an interpretation compatible with deliberate, knowing reason-responsiveness on the part of participants.
Age-friendly cities and communities: a review and future directions
Authors: Torku Alex , Chan Albert Ping Chuen , Yung Esther Hiu Kwan
Published: April 2020

The unprecedented increase in the ageing population, coupled with urbanisation, has led to a vast number of research publications on age-friendly cities and communities (AFCC). However, the existing reviews on AFCC studies are not sufficiently up-to-date for AFCC researchers. This paper presents a thorough analysis of the annual publication trend, the contributions of authors and institutions from different countries, and the trending research themes in the AFCC research corpus through a systematic review of 98 publications. A contribution assessment formula and thematic analysis were used for the review. The results indicated a growing AFCC research interest in recent times. Researchers and institutions from the United States of America, Canada, United Kingdom and Hong Kong made the highest contribution to the AFCC research corpus. The thematic analysis classified the AFCC research corpus into four main themes: conceptualisation; implementation and development; assessment; and challenges and opportunities. The themes indicate the current and future research patterns and issues to be considered in the development of AFCC and for interested researchers to make proposals for future research. Future directions are proposed, including suggestions on adopting new assessment methods and instruments, collaboration and cross-nation comparative research, considering older adults as place-makers and conducting a prior participatory analysis to maximise the participation of older adults.
Health and socio-economic inequalities by sexual orientation among older women in the United Kingdom: findings from the UK Household Longitudinal Study
Authors: Bécares Laia
Published: April 2020

Lesbian, gay, bisexual and queer (LGBQ) women living in the United Kingdom (UK) experience worse health than their heterosexual peers throughout their lives, but less is known about health inequalities in older age. This study uses population-level data to examine inequalities among LGBQ older women and women who prefer not to disclose their sexuality, compared to heterosexual women. Analyses use data from women aged 50 and older who were active in Waves 3 and 7 of the UK Household Longitudinal Study (also known as Understanding Society) (N = 8,209) to examine inequalities in socio-economic conditions, health and alcohol consumption across sexual orientation groups. LGBQ older women are on average younger and have higher socio-economic resources than their heterosexual peers. In contrast, women who prefer not to disclose their sexual orientation are older and have the lowest income and educational qualifications. Results of the health inequalities analyses show that LGBQ older women are almost twice as likely as heterosexual older women to engage in harmful alcohol consumption. Older women who prefer not to disclose their sexuality have worse physical and mental health than heterosexual older women. The health of LGBQ older women and women who prefer not to disclose their sexual orientation is one of the most neglected research areas in UK gerontology. Findings of this study contribute to our understanding of their social and health circumstances, and illuminate methodological limitations in existing data.
Clinical efficacy and safety of switch from bosentan to macitentan in children and young adults with pulmonary arterial hypertension: extended study results
Authors: Aypar Ebru , Alehan Dursun , Karagöz Tevfik , Aykan Hakan , Ertugrul İlker
Published: April 2020

Background:

Macitentan is an orally active, potent, dual endothelin receptor antagonist and is the only registered treatment for pulmonary arterial hypertension that significantly reduced morbidity and mortality in a long-term study.

Aim:

We have recently reported that switch from bosentan to macitentan significantly improved exercise capacity in children and young adults with pulmonary arterial hypertension in a 24-week prospective study and well tolerated without adverse events. We now aimed to evaluate clinical efficacy, safety of switch in a larger patient population, in a 24-month prospective study.

Methods:

This is a single-institution, 24-month prospective study. Patients ≥12 years with idiopathic/heritable, pulmonary arterial hypertension, or related to CHD or residual pulmonary arterial hypertension due to repaired congenital systemic-to-pulmonary shunts and on bosentan treatment were included. Concomitant treatment with oral phosphodiesterase type 5 inhibitors/inhaled prostanoids was allowed. Outcome measures included change from baseline to 24 months, in the 6-minute walk distance, functional class, oxygen saturation at rest/after walk distance test, and natriuretic peptide levels. Safety end points included adverse events, laboratory abnormalities.

Results:

Twenty-seven patients (19 adults/8 children, mean age: 21.1 ± 6.3 years (12–36), weight: 53.1 ± 15.7 kgs (26–87)) were included. Mean duration of macitentan treatment: 22.3 ± 3.9 months (9–24). Six-minute walk distance significantly improved from baseline (mean: 458 ± 79 m (300–620)) at 6 months (mean: 501 ± 73 m (325–616) + 43 m) (p < 0.05), at 12 months (mean: 514 ± 82 m (330–626) + 56 m) (p < 0.05), and at 24 months (mean: 532 ± 85 m (330–682) + 74 m) (p < 0.05). We observed a significant improvement during the first 6 months but no incremental improvement after 6 months (p > 0.05). Macitentan did not significantly change functional class, oxygen saturation, and natriuretic levels (p > 0.05). None of the patients had anaemia, hepatotoxicity, and peripheral edema.

Conclusions:

Our study is the first study which showed that switch from bosentan to macitentan improved exercise capacity in children and young adults with pulmonary arterial hypertension significantly in the first 6 months and compared to baseline in 24 months and well tolerated without adverse events.
The Epidemiology of Extreme Weather Event Disasters (1969-2018)
Authors: Keim Mark E.
Published: April 2020

Introduction:

This manuscript summarizes the global incidence, exposures, mortality, and morbidity associated with extreme weather event (EWE) disasters over the past 50 years (1969-2018).

Methods:

A historical database (1969-2018) was created from the Emergency Events Database (EM-DAT) to include all disasters caused by seven EWE hazards (ie, cyclones, droughts, floods, heatwaves, landslides, cold weather, and storms). The annual incidence of EWE hazards and rates of exposure, morbidity, and mortality were calculated. Regression analysis and analysis of variance (ANOVA) calculations were performed to evaluate the association between the exposure rate and the hazard incidence rate, as well as the association between morbidity and mortality incidence rates and rates of human exposure and annual EWE incidence.

Results:

From 1969-2018, 10,009 EWE disasters caused 2,037,415 deaths and 3,998,466 cases of disease. A reported 7,350,276,440 persons required immediate assistance. Floods and storms were the most common. Most (89%) of EWE-related disaster mortality was caused by storms, droughts, and floods. Nearly all (96%) of EWE-related disaster morbidity was caused by cold weather, floods, and storms. Regression analysis revealed strong evidence (R2 = 0.88) that the annual incidence of EWE disasters is increasing world-wide, and ANOVA calculations identified an association between human exposure rates and hazard incidence (P value = .01). No significant trends were noted for rates of exposure, morbidity, or mortality.

Conclusions:

The annual incidence of EWEs appears to be increasing. The incidence of EWEs also appears to be associated with rates of human exposure. However, there is insufficient evidence of an associated increase in health risk or human exposures to EWEs over time.
Anthropocene Geomorphic Change. Climate or Human Activities?
Authors: Cendrero Antonio , Forte Luis M. , Remondo Juan , Cuesta‐Albertos Juan A.
Published: April 2020

Key Points

Sedimentation rates and frequency of geomorphic disasters show a marked increase worldwide, especially after midtwentieth century

This points to an intensification of geomorphic processes, which could be one of the characteristics of the Anthropocene

Land surface change caused by human activities, rather than climate change, is very likely behind the intensification of geomorphic processes
Long‐Term Trajectory of Nitrogen Loading and Delivery From Mississippi River Basin to the Gulf of Mexico
Authors: Tian Hanqin , Xu Rongting , Pan Shufen , Yao Yuanzhi , Bian Zihao , Cai Wei‐Jun , Hopkinson Charles S. , Justic Dubravko , Lohrenz Steven , Lu Chaoqun , Ren Wei , Yang Jia
Published: April 2020

The large areal extent of hypoxia in the northern Gulf of Mexico has been partially attributed to substantial nitrogen (N) loading from the Mississippi River basin, which is driven by multiple natural and human factors. The available water quality monitoring data and most of the current models are insufficient to fully quantify N load magnitude and the underlying controls. Here we use a process‐based Dynamic Land Ecosystem Model to examine how multiple factors (synthetic N fertilizer, atmospheric N deposition, land use changes, climate variability, and increasing atmospheric CO2) have affected the loading and delivery of total nitrogen (TN) consisting of ammonium and nitrate (dissolved inorganic N) and total organic nitrogen from the Mississippi River basin during 1901–2014. The model results indicate that TN export during 2000–2014 was twofold larger than that in the first decade of twentieth century: Dissolved inorganic N export increased by 140% dominated by nitrate; total organic nitrogen export increased by 53%. The substantial enrichment of TN export since the 1960s was strongly associated with increased anthropogenic N inputs (synthetic N fertilizer and atmospheric N deposition). The greatest export of TN was in the spring. Although the implementation of N reduction has been carried out over the past three decades, total N loads to the northern Gulf of Mexico have not decreased significantly. Due to the legacy effect from historical N accumulation in soils and riverbeds, a larger reduction in synthetic N fertilizer inputs as well as improved N management practices are needed to alleviate ocean hypoxia in the northern Gulf of Mexico.
Bayesian Inversion of Wrapped Satellite Interferometric Phase to Estimate Fault and Volcano Surface Ground Deformation Models
Authors: Jiang Yu , González Pablo J.
Published: April 2020

Bayesian inference and an improved downsampling method is used to determine earthquake and volcano source parameters using a popular geodetic observation method, satellite radar interferometry. The main novelty of the proposed approach is that the interferometric wrapped phase can be directly inverted, circumventing the ill‐posed phase unwrapping processing step. Phase unwrapping errors severely affect the estimation of earthquake and volcano source parameters using interferometric observations. Therefore, it is desirable to avoid phase unwrapping completely. To overcome the need for phase unwrapping, we propose a downsampling algorithm and a method to estimate the covariance function of the wrapped phase and establish an appropriate misfit function between the observed and simulated wrapped phase. Uncertainties in source parameters are assessed with a Bayesian approach, and finally, the robustness of the inversion methodology is tested in multiple simulations including variable decorrelation and atmospheric noise simulations. The method is shown to be robust in challenging noise scenarios. It features an improvement in performance with the Bayesian approach, compared to similar previous methods, avoiding any influence of seed starting models and escaping local minima. The impact of a small percentage of incorrectly unwrapped phase observations in current state‐of‐the‐art methods is shown to strongly affect the estimation process. We conclude that in the cases where phase unwrapping is difficult or even impossible, the proposed inversion methodology with wrapped phase will provide an alternative approach to assess earthquake and volcano source model parameters.
Simulations of Tephra Fall Deposits From a Bending Eruption Plume and the Optimum Model for Particle Release
Authors: Mannen Kazutaka , Hasenaka Toshiaki , Higuchi Atsushi , Kiyosugi Koji , Miyabuchi Yasuo
Published: April 2020

We developed a simulation code named WT, which calculates tephra fallout from eruption plumes bent by wind. This proposed model assumes a series of radial particle sources arraying along the theoretically predicted trajectory of the plume center. To validate WT, we reconstructed the tephra dispersal during the 2011 sub‐Plinian eruption of Shinmoedake in Japan. This eruption was ideal for the validation because it was observed through various approaches; however, high‐resolution data of the fluctuating plume height made it difficult to determine a representative eruption time and plume height for running the simulations. Also, the amount of particle segregation along the plume could not be determined a priori. We thus implemented inversion calculations to study the optimum particle segregation pattern for possible ranges of time and the plume height, and the misfit between the observed and calculated mass loadings on the ground was evaluated. After this process and the following analysis, the optimum eruption time was determined for one of three major explosions (18:00 Japan Standard Time on 26 January). The optimum plume height was estimated to be 4 km above sea level, slightly lower than the estimation derived by the weather satellite (5 km). When wind shear exists, the WT model has a significant advantage in reconstructing tephra dispersal over the classical code named Tephra2, the prototype of WT. The WT inversion implies a simple segregation model from a well‐mixed plume, and further studies on particle segregation patterns will help to improve the accuracy of forward WT simulations.
Using SF6 and Xe to Monitor Gas Migration Through Explosion‐Generated Fracture Networks
Authors: Stroujkova A. , Gorman E. , Avendaño S. T. , Horne M. , Person M. A. , Hubbard P. , Salerno J. , Carrigan C. R. , Harp D. R. , Stauffer P. H.
Published: April 2020

We describe a field study where tracer gas was injected into a subsurface cavity created by a small chemical explosion beneath the water table. The main objective of the study is to compare the migration of sulfur hexafluoride (SF6) and xenon (Xe) through an explosion‐generated fracture network and to study the influence of ground water on gas transport. A mixture of tracer gases (50% of SF6 and 50% of Xe) was injected on 31 October 2018 and gas sampling continued until 8 November 2018. We observe similar trends in SF6 and Xe concentrations at four ground surface sampling sites. The changes in the SF6/Xe ratios with time show that more SF6 than Xe is observed during the barometric pressure lows when the absolute measured concentrations are highest. Conversely, the ratio SF6/Xe is less than 1 during the high‐pressure intervals when absolute measured concentrations are low. The results of the experiment suggest that during barometric pressure lows the tracer is migrating to the surface primarily by advective gas phase transport, whereas during barometric pressure highs, advection is suppressed and near‐surface evaporation of interstitial pore fluid with tracer dissolved in it becomes more important. Thus, the results of the experiment show that the gas concentrations at the surface are controlled by the combined effects of the gas dissolution into pore water and the barometric pressure fluctuations.
Methods for Rapidly Estimating Velocity Precision from GNSS Time Series in the Presence of Temporal Correlation: A New Method and Comparison of Existing Methods
Authors: Langbein John
Published: April 2020

Time series of position estimates from Global Navigational Satellite System (GNSS) are used to measure the velocities of points on the surface of the Earth. Along with the velocity estimates, a measure of the precision is needed to assess the quality of the velocity measurement. Here, I evaluate rate uncertainties provided by four different methods that have been applied to geodetic time series. The most rigorous approach uses a data covariance that incorporates a variety of noise processes relevant to geodetic time series but is computationally demanding. Two other approaches are efficient algorithms and are used widely, but both can provide less rigorous estimates of the rate uncertainty. I propose and evaluate a fourth method, which provides estimates of rate uncertainty closer to the rigorous approach but is significantly less computationally demanding. I have evaluated all three methods against the more rigorous method using both simulations and time series from 190 GNSS sites. For data best characterized as having a flicker type noise process, one of the widely used methods overestimates the uncertainty by up to a factor of 2, while the other widely used method underestimates the uncertainty by less than a factor of 2. For a random‐walk process, both methods underestimate the rate uncertainty by a factor of 3 to 5.
A Century of Southern California Coastal Ocean Temperature Measurements
Authors: Rasmussen Linda L. , Carter Melissa L. , Flick Reinhard E. , Hilbern Mary , Fumo James T. , Cornuelle Bruce D. , Gordon Bonnie K. , Bargatze Lee F. , Gordon R. Lee , McGowan John A.
Published: April 2020

Scripps Institution of Oceanography Pier has been the site of daily temperature measurements since the original structure was built in 1916. The time series is the longest continuous record of temperature on the Pacific Rim and is frequently cited as an indicator of ocean temperature trends in the region. The over 100‐year long record of daily surface temperature and slightly shorter bottom temperature data are presented here, with adjustment for bias owing to changes in sampling time of day. Data were generally collected near 8:00 a.m. in the early years, when water temperatures are cooler, and gradually shifted later in the day, when temperatures are warmer. In addition, cold surges from irregular internal tidal bores complicated attempts to estimate daily heating‐cooling cycles solely as a function of time of day. To isolate the effect of the solar heating cycle, adjustments were calculated based on seasonally variable diurnal solar heating using a surface ocean heating model and locally measured insolation data. Although the observed warming trends in nearshore temperatures are reduced by about 0.2 °C per century in the adjusted data, they still retain a significant increase of 1.24 °C per century at the surface and 1.67 °C per century in bottom waters.
Winter Arctic Sea Ice Thickness From ICESat‐2 Freeboards
Authors: Petty Alek A. , Kurtz Nathan T. , Kwok Ron , Markus Thorsten , Neumann Thomas A.
Published: April 2020

National Aeronautics and Space Administration's (NASA's) Ice, Cloud, and land Elevation Satellite‐2 (ICESat‐2) mission was launched in September 2018 with the primary goal of monitoring our rapidly changing polar regions. The sole instrument onboard, the Advanced Topographic Laser Altimeter System, is now providing routine, very high‐resolution, surface elevation data across the globe, including the Arctic and Southern oceans. In this study, we demonstrate our new processing chain for converting the along‐track ICESat‐2 sea ice freeboard product (ATL10) into sea ice thickness, focusing our initial efforts on the Arctic Ocean. For this conversion, we primarily make use of snow depth and density data from the NASA Eulerian Snow on Sea Ice Model. The coarse resolution (~100 km) snow data are redistributed onto the high‐resolution (approximately 30–100 m) ATL10 freeboards using relationships obtained from snow depth and freeboard data collected by NASA's Operation IceBridge mission. We present regional sea ice thickness distributions and highlight their seasonal evolution through our first winter season of data collection. We include ice thickness uncertainty estimates, while also acknowledging the limitations of these estimates. We generate a gridded monthly thickness product and compare this with various monthly sea ice thickness estimates obtained from European Space Agency's CryoSat‐2 satellite mission, with ICESat‐2 showing consistently lower thicknesses. Finally, we compare our February/March 2019 thickness estimates to ICESat February/March (19 February to 21 March) 2008 ice thickness estimates using the same input assumptions, which show an ~0.37 m or ~20% thinning across an inner Arctic Ocean domain in this 11‐year time period.
Modeling Spatial Heterogeneity in Surface Turbulent Heat Flux in the U.S. Southern Great Plains
Authors: Williams Ian N. , Lee Jungmin M. , Tadić Jovan , Zhang Yunyan , Chu Housen
Published: April 2020

Advances in numerical modeling of cloud dynamics are driving a need for improved land model prediction at convective storm scales. In this study, satellite and ground‐based vegetation remote sensing data were combined with land model experiments to more accurately characterize land surface spatial heterogeneity in the Community Land Model (CLM4.0). The new subgrid classification of plant functional types (PFT) and leaf area index (LAI) enables consistent comparison between models and ground‐based flux measurements in the U.S. southern Great Plains. Errors in vegetation data sets (inferred from comparison between 250 m satellite and ground‐based LAI), while large, had less impact on the simulated characteristics of spatial heterogeneity compared to errors in model representation of surface energy partitioning (between latent and sensible heat flux) and its relationship to LAI. Predicted spatial heterogeneity in surface energy partitioning was enhanced after replacing soil and stomatal resistance parameters with a new set that better predicts the observed relationship to LAI. These modifications increase the number of smaller (mesoscale) dry land patches having higher sensible heat flux. The parameter experiments suggest that vegetation state and processes (transpiration) act to broaden the size spectrum of surface heat flux heterogeneity, which can influence clouds and convective initiation. Moreover, improvements in vegetation input data and model parameters had partially compensating effects on surface flux heterogeneity, indicating the importance of evaluating input data and parameterizations together to improve prediction at higher spatial resolutions.
The Provenance of Regolith at the Chang'e‐5 Candidate Landing Region
Authors: Xie Minggang , Xiao Zhiyong , Zhang Xunyu , Xu Aoao
Published: April 2020

The upcoming lunar Chang'e‐5 mission is scheduled to land near Mons Rümker, in northern Oceanus Procellarum, and return samples with masses up to 2 kg from depths up to ~2 m. A clear understanding of the regolith components in the candidate landing region is crucial to both the selection of sampling sites and the interpretation of the geological affinities for the returned samples. We quantitatively estimate the abundance of distantly sourced particles (DSPs) in the regolith at the landing region using an updated ballistic sedimentation model. Our results suggest that older units have a higher abundance of DSPs. In the targeted landing area, the total abundance of DSPs on the surface of the regolith varies from approximately 12% to 20%, and most of the DSPs on the surface are ejecta from the Pythagoras (~5%) and/or Aristarchus (~7%) craters. The youngest geological unit, which is located in the easternmost sector of the landing region, possesses the least DSPs in the regolith. Therefore, sampling the eastern unit has a higher potential of revealing both the petrological characteristics and age of the youngest mare basalt, which are fundamentally important to improve both the lunar crater chronology and the understanding of late‐stage evolution of the Moon. Our results also indicate that the anorthositic material within the shallow regolith is most likely ejected from the Pythagoras and Aristarchus craters, which could further improve the understanding of lunar geology and chronology.
On‐Deck Seismology: Lessons from InSight for Future Planetary Seismology
Authors: Panning M. P. , Pike W. T. , Lognonné P. , Banerdt W. B. , Murdoch N. , Banfield D. , Charalambous C. , Kedar S. , Lorenz R. D. , Marusiak A. G. , McClean J. B. , Nunn C. , Stähler S. C. , Stott A. E. , Warren T.
Published: April 2020

Before deploying to the surface of Mars, the short‐period (SP) seismometer of the InSight mission operated on deck for a total of 48 hr. This data set can be used to understand how deck‐mounted seismometers can be used in future landed missions to Mars, Europa, and other planetary bodies. While operating on deck, the SP seismometer showed signals comparable to the Viking‐2 seismometer near 3 Hz where the sensitivity of the Viking instrument peaked. Wind sensitivity showed similar patterns to the Viking instrument, although amplitudes on InSight were ∼80% larger for a given wind velocity. However, during the low‐wind evening hours, the instrument noise levels at frequencies between 0.1 and 1 Hz were comparable to quiet stations on Earth, although deployment to the surface below the Wind and Thermal Shield lowered installation noise by roughly 40 dB in acceleration power. With the observed noise levels and estimated seismicity rates for Mars, detection probability for quakes for a deck‐mounted instrument is low enough that up to years of on‐deck recordings may be necessary to observe an event. Because the noise is dominated by wind acting on the lander, though, deck‐mounted seismometers may be more practical for deployment on airless bodies, and it is important to evaluate the seismicity of the target body and the specific design of the lander. Detection probabilities for operation on Europa reach over 99% for some proposed seismicity models for a similar duration of operation if noise levels are comparable to low‐wind time periods on Mars.
Stratospheric Injection of Massive Smoke Plume From Canadian Boreal Fires in 2017 as Seen by DSCOVR‐EPIC, CALIOP, and OMPS‐LP Observations
Authors: Torres O. , Bhartia P. K. , Taha G. , Jethva H. , Das S. , Colarco P. , Krotkov N. , Omar A. , Ahn C.
Published: April 2020

A carbonaceous aerosol plume associated with wildfires in British Columbia in August 2017 reached the stratosphere a few days following the fires onset. The Earth Polychromatic Imaging Camera (EPIC) sensor onboard the Deep Space Climate Observatory (DSCOVR) satellite observed the spatial and temporal evolution of the plume for about 6 weeks. EPIC's near‐hourly observations of the Earth's sunlit disk allowed for monitoring the smoke plume several times per day. High ultraviolet aerosol index values pointed to the presence of an aerosol layer in the upper troposphere and lower stratosphere, confirmed with Cloud‐Aerosol Lidar with Orthogonal Polarization (CALIOP) lidar observations. EPIC aerosol optical depth retrievals and CALIOP information on layer height were used to estimate the stratospheric portion of the aerosol mass, reaching a maximum of 268 ± 86 Kt 3 days after the onset of the wildfires. About 10% of this aerosol mass reached the stratosphere on 13 August, whereas the remaining 90% did so over the following 2 days. Observed daytime and inferred nighttime rates of stratospheric aerosol mass increase showed a more rapid daytime increase, consistent with variability in diurnal insolation, suggesting that solar radiation driven processes may have contributed to the observed stratospheric aerosol mass increase. Global modeling results support the possible role of diabatic aerosol self‐lofting. Ozone Mapping and Profiler Suite Limb Profiler (OMPS‐LP) aerosol retrievals showed the spread of stratospheric aerosols in the Northern Hemisphere, reaching peak concentration between October 2017 and January 2018, when about half the Northern Hemisphere experienced a detectable enhancement of stratospheric aerosols with respect to preinjection conditions. The lifetime and aerosol mass of this smoke event were comparable to those of a moderate volcanic eruption.
GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513
Authors: Marques Tiago Reis , Ashok Abhishekh H. , Angelescu Ilinca , Borgan Faith , Myers Jim , Lingford-Hughes Anne , Nutt David J. , Veronese Mattia , Turkheimer Federico E. , Howes Oliver D.
Published: April 2020

A loss of GABA signaling is a prevailing hypothesis for the pathogenesis of schizophrenia. Preclinical studies indicate that blockade of the α5 subtype of the GABA receptor (α5-GABAARs) leads to behavioral phenotypes associated with schizophrenia, and postmortem evidence indicates lower hippocampal α5-GABAARs protein and mRNA levels in schizophrenia. However, it is unclear if α5-GABAARs are altered in vivo or related to symptoms. We investigated α5-GABAARs availability in antipsychotic-free schizophrenia patients and antipsychotic-medicated schizophrenia patients using [11C]Ro15-4513 PET imaging in a cross-sectional, case–control study design. Thirty-one schizophrenia patients (n = 10 antipsychotic free) and twenty-nine matched healthy controls underwent a [11C]Ro15-4513 PET scan and MRI. The α5 subtype GABA-A receptor availability was indexed using [11C]Ro15-4513 PET imaging. Dynamic PET data were analyzed using the two-tissue compartment model with an arterial plasma input function and total volume of distribution (VT) as the outcome measure. Symptom severity was assessed using the PANSS scale. There was significantly lower [11C]Ro15-4513 VT in the hippocampus of antipsychotic-free patients, but not in medicated patients (p = 0.64), relative to healthy controls (p < 0.05; effect size = 1.4). There was also a significant positive correlation between [11C]Ro15-4513 VT and total PANSS score in antipsychotic-free patients (r = 0.72; p = 0.044). The results suggest that antipsychotic-free patients with schizophrenia have lower α5-GABAARs levels in the hippocampus, consistent with the hypothesis that GABA hypofunction underlies the pathophysiology of the disorder.
Reinventing quantitative genetics for plant breeding: something old, something new, something borrowed, something BLUE
Authors: Bernardo Rex
Published: April 2020

The goals of quantitative genetics differ according to its field of application. In plant breeding, the main focus of quantitative genetics is on identifying candidates with the best genotypic value for a target population of environments. Keeping quantitative genetics current requires keeping old concepts that remain useful, letting go of what has become archaic, and introducing new concepts and methods that support contemporary breeding. The core concept of continuous variation being due to multiple Mendelian loci remains unchanged. Because the entirety of germplasm available in a breeding program is not in Hardy–Weinberg equilibrium, classical concepts that assume random mating, such as the average effect of an allele and additive variance, need to be retired in plant breeding. Doing so is feasible because with molecular markers, mixed-model approaches that require minimal genetic assumptions can be used for best linear unbiased estimation (BLUE) and prediction. Plant breeding would benefit from borrowing approaches found useful in other disciplines. Examples include reliability as a new measure of the influence of genetic versus nongenetic effects, and operations research and simulation approaches for designing breeding programs. The genetic entities in such simulations should not be generic but should be represented by the pedigrees, marker data, and phenotypic data for the actual germplasm in a breeding program. Over the years, quantitative genetics in plant breeding has become increasingly empirical and computational and less grounded in theory. This trend will continue as the amount and types of data available in a breeding program increase.
Water-mediated crystallohydrate–polymer composite as a phase-change electrolyte
Authors: Tai Ziyang , Wei Junjie , Zhou Jie , Liao Yue , Wu Chu , Shang Yinghui , Wang Baofeng , Wang Qigang
Published: April 2020

With the world’s focus on wearable electronics, the scientific community has anticipated the plasticine-like processability of electrolytes and electrodes. A bioinspired composite of polymer and phase-changing salt with the similar bonding structure to that of natural bones is a suitable electrolyte candidate. Here, we report a water-mediated composite electrolyte by simple thermal mixing of crystallohydrate and polymer. The processable phase-change composites have significantly high mechanical strength and high ionic mobility. The wide operating voltage range and high faradic capacity of the composite both contribute to the maximum energy density. The convenient assembly and high thermal-shock resistance of our device are due to the mechanical interlocking and endothermic phase-change effect. As of now, no other non-liquid electrolytes, including those made from ceramics, polymers, or hydrogels, possess all of these features. Our work provides a universal strategy to fabricate various thermally manageable devices via phase-change electrolytes.
Hydrogen migration at restructuring palladium–silver oxide boundaries dramatically enhances reduction rate of silver oxide
Authors: O’Connor Christopher R. , van Spronsen Matthijs A. , Egle Tobias , Xu Fang , Kersell Heath R. , Oliver-Meseguer Judit , Karatok Mustafa , Salmeron Miquel , Madix Robert J. , Friend Cynthia M.
Published: April 2020

Heterogeneous catalysts are complex materials with multiple interfaces. A critical proposition in exploiting bifunctionality in alloy catalysts is to achieve surface migration across interfaces separating functionally dissimilar regions. Herein, we demonstrate the enhancement of more than 104 in the rate of molecular hydrogen reduction of a silver surface oxide in the presence of palladium oxide compared to pure silver oxide resulting from the transfer of atomic hydrogen from palladium oxide islands onto the surrounding surface formed from oxidation of a palladium–silver alloy. The palladium–silver interface also dynamically restructures during reduction, resulting in silver–palladium intermixing. This study clearly demonstrates the migration of reaction intermediates and catalyst material across surface interfacial boundaries in alloys with a significant effect on surface reactivity, having broad implications for the catalytic function of bimetallic materials.
Manipulating dehydrogenation kinetics through dual-doping Co3N electrode enables highly efficient hydrazine oxidation assisting self-powered H2 production
Authors: Liu Yi , Zhang Jihua , Li Yapeng , Qian Qizhu , Li Ziyun , Zhu Yin , Zhang Genqiang
Published: April 2020

Replacing sluggish oxygen evolution reaction (OER) with hydrazine oxidation reaction (HzOR) to produce hydrogen has been considered as a more energy-efficient strategy than water splitting. However, the relatively high cell voltage in two-electrode system and the required external electric power hinder its scalable applications, especially in mobile devices. Herein, we report a bifunctional P, W co-doped Co3N nanowire array electrode with remarkable catalytic activity towards both HzOR (−55 mV at 10 mA cm−2) and hydrogen evolution reaction (HER, −41 mV at 10 mA cm−2). Inspiringly, a record low cell voltage of 28 mV is required to achieve 10 mA cm−2 in two-electrode system. DFT calculations decipher that the doping optimized H* adsorption/desorption and dehydrogenation kinetics could be the underlying mechanism. Importantly, a self-powered H2 production system by integrating a direct hydrazine fuel cell with a hydrazine splitting electrolyzer can achieve a decent rate of 1.25 mmol h−1 at room temperature.
Unusual KIE and dynamics effects in the Fe-catalyzed hetero-Diels-Alder reaction of unactivated aldehydes and dienes
Authors: Yang Yuhong , Zhang Xiaoyong , Zhong Li-Ping , Lan Jialing , Li Xin , Li Chuang-Chuang , Chung Lung Wa
Published: April 2020

Hetero-Diels-Alder (HDA) reaction is an important synthetic method for many natural products. An iron(III) catalyst was developed to catalyze the challenging HDA reaction of unactivated aldehydes and dienes with high selectivity. Here we report extensive density-functional theory (DFT) calculations and molecular dynamics simulations that show effects of iron (including its coordinate mode and/or spin state) on the dynamics of this reaction: considerably enhancing dynamically stepwise process, broadening entrance channel and narrowing exit channel from concerted asynchronous transition states. Also, our combined computational and experimental secondary KIE studies reveal unexpectedly large KIE values for the five-coordinate pathway even with considerable C–C bond forming, due to equilibrium isotope effect from the change in the metal coordination. Moreover, steric and electronic effects are computationally shown to dictate the C=O chemoselectivity for an α,β-unsaturated aldehyde, which is verified experimentally. Our mechanistic study may help design homogeneous, heterogeneous and biological catalysts for this challenging reaction.