bluuebunny/crossref_metadata_2025 huggingface dataset:
In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes
Authors: MUSAVI BAFRUI Najmossadat , HASHEMI HAZAVEH Seyed Jamal , BAYAT Mansour
Published: November 2020

Background: Dermatophytosis is one of the most common fungal infections in humans. Antifungals such as fluconazole are effectively used for treating dermatophytosis; however, drug resistance was observed in many cases. Therefore, a newer treatment strategy is essential.
Methods: This study (Conducted in the Laboratory of the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2018) evaluated the antifungal susceptibility of nano fluconazole compared to conventional fluconazole on dermatophyte isolates using CLSI M38-A2guidelines. Dermatophyte species isolated from clinical cases of dermatophytosis were identified using PCR sequencing techniques. Zeta potential and size of the nano particles containing fluconazole were measured; scanning electron microscope (SEM) was used to determine nano particle structure.
Results: The size of liposomal fluconazole obtained was 88.9  12.14 nm with –20.12  3.8 mV for zeta potential. The encapsulation rate for fluconazole was 75.1  4.2%. MIC50 for the three tested species was 32, 16, and 8 μg/ml for Trichophyton interdigitale, T. rubrum, and Epidermophyton floccosum isolates, respectively. The corresponding values for nano fluconazole were 8 μg/ml for the three tested species.
Conclusion: MIC value for nano-fluconazole was lower than conventional fluconazole in all dermatophytes species tested; therefore, nano-fluconazole could inhibit the growth of dermatophytes better than fluconazole at a lower concentration of the drug.
Population Attributable Risk of Hyperuricemia in Hypertension Incidence in 20-74-Year-Old Population during a 10-Year Longitudinal Cohort: Yazd Healthy Heart Cohort
Authors: MOHAMMADHOSEINI Mojtaba , NAMAYANDEH Seyedeh Mahdieh , FALLAHZADEH Hosein , MAJIDPOUR Fatemeh , SADR-BAFGHI Seyed Mahmoud , SOLTANI Mohammadhosein , HADIANI Leila , SAREBANHASSANABADI Mohammadtaghi , NOUGH Hossein , KARIMI Ahmad , ASKARI Maryam
Published: November 2020

Background: The population attributable risk (PAR) percent has used widely in public health policy. We aimed to calculate the attribute risk of hypertension due to hyperuricemia by Levin's formulas compare to direct PAR calculation method.
Methods: This was a sub-study of Yazd Healthy Heart Cohort (YHHC). Overall, 1256 normotensive individuals were enrolled through multistage randomized cluster sampling and followed up for mean 9.8 years, from 2005-2015. The threshold cutoff point of the hyperuricemia was considered equal and more than 75th percentile that equal to 5.5 mg/dl for men and 4.3mg/dl for women. To calculate the attributable risk of hyperuricemia in developing hypertension, two methods were applied. Levin's formulas and direct PAR estimation by population risk calculation via exposure prevalence weighted formula. Multiple logistic regression was used for estimate of odds ratio (OR) of hyperuricemia in developing hypertension. We calculated Relative Risk (RR) from OR. The data were analyzed using SPSS software version 16. A significant level of 0.05 was considered.
Results: Hypertension developed in 44.7% of individuals with uric acid level ≥ 75th percentile vs. 35.6% of other individuals (P=0.024). Attributable risk (AR) of hyperuricemia in hypertension incidence was 9.1%. PAR of hyperuricemia for hypertension incidence by using two methods mentioned before was 6%, 5.8% respectively.
Conclusion: The results of the study confirmed the noticeable contribution of hyperuricemia as an independent other risk factor for the occurrence of hypertension. PAR of hyperuricemia for hypertension incidence by using two methods almost near was 6%, 5.8% respectively.
Development of High Resolution Melting Analysis as a Diag-nostic Tool for Molecular Detection of Toxoplasma Infection in Pregnant Women and HIV Positive Cases
Authors: HOSSEINI-SAFA Ahmad , SHOJAEE Saeedeh , SALAMI Seyed Alireza , MOHEBALI Mehdi , HANTOUSHZADEH Sedigheh , MOUSAVI Parisa , DEHGHAN MANSHADI Seyed Ali , KESHAVARZ VALIAN Hossein
Published: November 2020

Background: Toxoplasma gondii is an obligate intracellular protozoan with worldwide distribution. Diagnosis of toxoplasmosis is a very critical issue, especially in pregnant women and immunocompromised patients. The aim of this study was rapid detection of T. gondii DNA in peripheral blood samples (PBS) employing HRM technique and using RE gene.
Methods: Totally, 242 samples from pregnant women and human immunodeficiency virus (HIV) patients were collected from different hospitals and medical centers of Tehran during Oct 2017 to Dec 2018. High resolution melting analysis (HRM) using partial sequences of repetitive element (RE) gene was done and compared with ELISA test.
Results: Overall, 51 were positive for acute toxoplasmosis that among them, 12 and 20 reported as positive in pregnant women and HIV+ patients, respectively using HRM technique. Among 70 patients in chronic phase of disease, 10 and 3 samples were reported as positive for pregnant women and HIV+ patients respectively. From 121 negative control, 3 (4.62%) samples associated with HIV+ patients, showed positive real-time PCR and HRM analysis results.
Conclusion: For the first time, HRM technique via employing RE gene was used for detection of T. gondii infection in PBS. This method is suitable, helpful and in parallel with serological methods for early diagnosis of acute as well as active form of toxoplasmosis in pregnant women and HIV+ patients. The use of techniques based on melt curve and through employing next-generation dyes for diagnosis of T. gondii would be accessible for patients in developing countries.
Correlations between COVID-19 Case Growth and Mental Health-Related Internet Search: An Unexpected Finding
Authors: ZHANG Tenghao
Published: November 2020

The article's abstract is not available.
What Is Needed for a Successful Second Chance for Accused Researchers?
Authors: LEE Jung Hun , JEON Jeong Ho , LEE Sang Hee
Published: November 2020

The article's abstract is not available.
Relationship between Attachment Styles and Risk Behavior (Smoking and Bullying) among Secondary School Students: An Experience from Hulu Langat, Malaysia
Authors: MOHAMMADZADEH Marjan , AWANG Hamidin , JUN Cheah Yt , HASHIM Nor Fauziah , PREMKUMAR Archana
Published: November 2020

The article's abstract is not available.
Bone Turnover in Azerbaijani Patients with Type 2 Diabetes
Authors: SAFAROVA Sain Sattar
Published: November 2020

The article's abstract is not available.
An Early Description of Hematemesis in Persian Medicine
Authors: AMINIAN Ali , YOUSEFI Seyde Sedighe
Published: November 2020

The article's abstract is not available.
The Issue of the Correlation between Legal Regimes of Territories of National Parks and Settlements Located Therein in the Russian Federation
Authors:   Chief Executive Officer of the HEALTH OF THE NATION Foundation for Facilitation of Raising the Level of Healthcare Service Provision to the Population LL.D., Kachushkin Sergey V.
Published: November 2020

The study devotes its text to the important problem of the actual coexistence of Russian Federation’s national parks and some Russian settlements, mainly on the Irkutsk region example. The scientific article includes in its structure, among other things, the Pribaikalsky National Park’s brief description, as well as specific examples from the Irkutsk Region practice, in which settlements are still preserved and actively developed in the Pribaikalsky National Park. The work objectively takes into account the prevailing set of the Russian Federation’s environmental and land laws that regulate the national parks formation and functioning, in the sense that it allows to ensure genuine environmental safety within the borders of Russian national parks. The study actively criticizes the some individuals’ point of view, being regularly observed and permanently promoted at various levels of national government, supporting the idea of indispensable legal and actual preservation of the current state of affairs, as well as the idea of easing the existing environmental legislation norms admissibility, as a position that hides the true aspirations of these persons for achieving goals for the population well-being. At the same time, contrary to this position, the article proposes some different ways to improve national legislation in order to reduce and neutralize existing risks for the Russian ecological system. The article has a fairly high scientific and educational value, it is designed for a wide range of readers, both being related to the political or legal professions, and to environmental or other socially significant activities.
ONLINE REGULATION OF DISPUTES IN ELECTRONIC COMMERCE
Authors:   Acting Head of the Department of Corruption Prevention Methodology of the Institute of Legislation and Comparative Law under the Government of the Russian Federation, Tsirin Artem M. , Tsirina Madina A. ,   Leading Research Scientist of the Department of International Private Law of the Institute of Legislation and Comparative Law under the Government of the Russian Federation
Published: November 2020

This article on Online Dispute Resolution in E-Commerce provides a detailed analysis of the international legal framework for conciliation and online dispute resolution. The authors analyze the conceptual apparatus of online dispute resolution in the field of e-commerce, the subject of this category of disputes, as well as the person composition of their dispute resolution, including the relevant specializedorganizations, includingmediationcenters, andaspecializedentitiessuchasInternetombudsmen, e-commerceombudsmen and etc. Special attention is paid to the rules ensuring transparency of information about the functioning of platforms for online dispute resolution, and about the persons administering their activities. The article examines the online dispute resolution procedure, as well as the activities of online dispute resolution platforms and persons administering their activities, including their functional responsibilities. The authors come to the conclusion that at a certain stage of the introduction of digital technologies there is competition between legal norms and regulations and algorithms that mediate the use of these technologies. Unfortunately, both are subject to the threat of corruption. In this regard, a proposal is being formulated regarding the establishment of anti-corruption restrictions and obligations, and a requirements to avoid conflicts of interest with respect to persons administering online dispute resolution platforms.
LEGAL EXPERIMENT AS A MECHANISM OF TESTING TECHNOLOGIES OF ELECTRONIC TRADE
Authors:   Senior Research Scientist of the Department of Corruption Prevention Methodology of the Institute of Legislation and Comparative Law under the Government of the Russian Federation PhD (Law), Cherepanova Ekaterina V.
Published: November 2020

E-commerce is currently a dynamically developing branch of the Russian economy. Owing to modern digital technologies, new opportunities are opening up for business, government and consumers. The development of this scope requires the adoption of balanced legal decisions, which is not always possible in the context of the emergence of new and transformation of existing e-commerce technologies. And here it is appropriate to talk about the need for legal experiments in order to create effective legal regulators in the field of electronic commerce in the future. The author outlines the main features of a legal experiment, presents arguments justifying the need for such experiments in the field of electronic commerce. The experience of the Russian Federation and a number of foreign countries in organizing and conducting such experiments is also analyzed. Based on the results of the study, it was concluded that conducting a legal experiment contributes to a more successful implementation of e-commerce technologies in the Russian legal system, increases the efficiency of adopted legal acts, the quality of activities of public authorities and business, and as a result, the achievement of the intended results.
THE PECULIARITIES OF THE IMPLEMENTA-TION OF BASEL III PRINCIPLES IN BANKING LAWS OF THE RUSSIAN FEDERATION
Authors:   Professor of the Department of Civil and Legal Disciplines of the Plekhanov Russian University of Economics Head of the Department of Legal Disciplines of the Higher School of State Audit of the Lomonosov Moscow State University (MSU) LL.D., Professor, Krokhina Yulia A.
Published: November 2020

The Russian Federation has formed the foundation for the full implementation of Basel III recommendations in the Russian banking system. However, this process is not yet complete, due to both subjective and objective reasons. The article analyzes the objective reasons for the postponement of the full implementation of the Basel III principles due to the COVID-19 pandemic. The features of the introduction into Russian practice of procedures and approaches for calculating the indicator and ratio of short-term liquidity, as well as assessing operational risks. On the basis of the analysis carried out, recommendations for improving banking legislation are given.
THE LEGAL REGULATION OF INTERNAL CONTROL AND AUDIT IN DEVELOPMENT FINANCE INSTITUTIONS
Authors:   Postgraduate Student of the Department of Legal Disciplines of the Higher School of State Audit of the Lomonosov Moscow State University (MSU), Brykin Konstantin I.
Published: November 2020

The article deals with the study of the legal regulation of internal control and audit in financial development institutions. The study is based both on the analysis of the provisions of regulatory legal acts, and internal regulatory documents of financial development institutions. The author notes the need to organize the development of independent functions of internal control and internal audit in financial institutions, considers the specifics of the functional and administrative accountability of these functions, and also suggests special regulation of labor relations with employees of internal control and internal audit services in financial development institutions.
LEGAL ISSUES OF WILL CONTESTABILITY (PART 1)
Authors:   Private Practice Lawyer, Grivkov Oleg D. , Shichanin Aleksey V. ,   Adviser to Chief Executive Officer for Legal Affairs at Yurprofi Center Limited Liability Company PhD (Law)
Published: November 2020

The article is devoted to the analysis of current legal problems related to the judicial challenge of wills. It is concluded that the main attention in the analysis of these problems should be paid to the forensic psychological and psychiatric examination of such a category of disputes, since it is the key evidence in a civil case of contesting a will. The problems of legal capacity of testators, the complexity of the system of evidence for this category of disputes from the point of view of notary and judicial practice are revealed.
FAMILY AND INHERITANCE LAW IN THE LIFE OF THE MERCHANT CLASS OF THE XIX CENTURY (ON THE EXAMPLE OF ENTREPRENEURS OF THE VLADIMIR GOVERNORATE)
Authors:   Professor of the Department of Russian History of the Ivanovo State University Doctor of History, Professor, Baldin Kirill E. , Kuznetsova Olga A. ,   Associate Professor of the Ivanovo Branch of the International Law Institute PhD (History), Associate Professor, Stolyarov Dmitriy A. ,   Associate Professor of the Ivanovo Branch of the International Law Institute PhD (History)
Published: November 2020

The article analyzes archival documents that reflect the life of the industrial and commercial estate of the Vladimir province of the XIX century. These materials contain a significant array of paperwork on family and inheritance law. Their introduction into scientific circulation allows us to understand the laws governing the functioning of the system of protecting property and civil rights of the population, in the conditions of developing market relations and the dynamic growth of capital of the business class. Also, the documents examined by us allow us to determine the forms of interaction, control and subordination of administrative bodies. These documents to a large extent characterize the quality of life of the entrepreneurial class, mechanisms for regulating the private interests of citizens on the basis of legal norms that existed at a certain historical stage.
EXERCISING SOME CORPORATE RIGHTS BY HEIRS AND THE SPOUSE OF A MEMBER OF A LIMITED LIABILITY COMPANY
Authors:   Associate Professor of the Department of Civil Law of the Rostov Branch of the Russian State University of Justice PhD (Law), Rudik Inna E.
Published: November 2020

Currently in judicial practice there are different approaches to understanding the scope of rights of the heirs and spouse of a participant in a limited liability company in relation to this Corporation. It makes difficult in some cases to protect the rights of these individuals who are interested in protecting the company’s assets from illegal encroachments by other participants, management, or third parties. The author substantiates the position about granting to this persons rights to invalidate decisions of the meeting and transactions of the corporation, transactions of other participants of the corporation. In this connection, were set the tasks: to determine the essence of the term “corporate share”; to develop criteria for determining the situations when the aforesaid rights should be recognized for the heirs and the spouse.
Statutory Aspects of International and Transnational Search for Hiding Terrorists, Extremists and Mercenaries: The National and Foreign Experience
Authors:   Chief Research Scientist of the Research Institute of the Federal Penitentiary Service of Russia LL.D., Associate Professor, Rumyantsev Nikolay V. , Tarasov Maksim Yu. ,   Leading Research Scientist of the Research Institute of the Federal Penitentiary Service of Russia PhD (Law), Class 3 State Counsellor of Justice
Published: November 2020

The article defines statutory grounds for the international and transnational search for terrorists and mercenaries, determines the algorithm of actions in this sphere and the collection of data on the location of wanted criminals, the opportunity for their extradition and prevention of attempts of persons trained in terrorist groups and suicide attackers to penetrate to the Commonwealth of Independent States (hereinafter referred to as the CIS). The publication lists events aimed at the identification of and search for CIS citizens having taken part in military operations in other countries on the side of terrorist and extremist groups and illegal armed formations (hereinafter referred to as the IAF). The authors give justified proposals for the improvement and functioning of the system of international and transnational search, review various solutions of the issues related to the legal mechanism problems, the procedure for mutual exchange of the information on coordination of and procedure for search, supervision and control thereof.
Some Issues of Sentence Enforcement in Respect of Convicts Suffering from a Gender Identity Disorder: Russian, International and Foreign Aspects
Authors:   Head of the Department of Criminal and Penal Law of the Academy of the FPS of Russia LL.D., Associate Professor, Skiba Andrey P. , Myakhanova Aleksandra N. ,   Associate Professor of the Department of Criminal Law and Criminology of the Buryat State University named after D. Banzarov Judge Emeritus, Pakhorukov Aleksandr A. ,   Graduate Student of the Buryat State University named after D. Banzarov
Published: November 2020

The article justifies the need for the improvement of organizational and legal issues of sentence enforcement in respect of convicts suffering from a gender identity disorder (transgender, transsexual people, etc.) as one of the penal law development areas. The authors bring forward a number of recommendations for the improvement of penal and other laws of Russia taking into account studies of the legal regulation and law enforcement in respect of convicts suffering from a gender identity disorder, international provisions and foreign experience in this sphere.
Analysis on Reconstruction Design of Old Urban Roads
Authors: Kuang Degang
Published: November 2020

With the continuous development of cities, the urban roads built in the early days can no longer meet the needs of modern urban transportation. Therefore, in the current urban development and construction process, the reconstruction of old roads is the key construction content. At the same time, the transformation of old urban roads is also an inevitable requirement to improve the urban road system and improve the level of urban communication infrastructure construction and transportation service capacity. The reconstruction of old roads meets the requirements of the overall planning and construction of modern cities, and plays a vital role in promoting the development and progress of urban economy and improving the quality of life of urban residents. In the process of urban old road reconstruction, because the original urban road environment is very complex and involves many factors, the rational design of the construction scheme of the old road reconstruction project is the key factor affecting the effect of the old road reconstruction. This paper makes an in-depth exploration and analysis of the old road reconstruction design of urban roads, and puts forward scientific and reasonable suggestions in combination with the actual situation, so as to provide reliable theoretical support for improving the old road reconstruction level and promoting the urbanization development process in China.
Medycyna stylu życia jako prozdrowotny trend współczesnego prosumenta
Authors: Czerska Iwona , Trojanowska Angelika , Korpak Tetiana
Published: November 2020

The aim of this study is to present the profile of the modern prosumer and analyze their behavior on the health services market in the context of the latest health-promoting trend — lifestyle medicine. The patient’s participation in medical diagnostics was discussed. Attention was paid to the reasons for transformation of medical systems, among others due to changes in the patient’s needs. The theoretical aspects of lifestyle medicine, including evidence-based medicine (EBM), were discussed. Finally, an analysis of the lifestyle of Polish consumers was made based on the results of own study. Less than 20% of respondents are familiar with the term “lifestyle medicine”. Most respondents identify this term with a healthy lifestyle. The respondents’ declarations show that the modern consumer leads a healthy lifestyle, regularly engaging in sports and eating properly balanced meals. As an informed consumer, he or she reads the labels on the packaging and considers each purchase very carefully. He or she is also vulnerable to advertising and other marketing tools, and is aware of this. Nearly 61% of respondents do not know the term “prosumer”. For other people, a prosumer is the modern consumer who consciously and actively makes choices, is involved in co-creating the product and takes part in its promotion.
Opinie studentów na temat konsumpcji mięsa i jej konsekwencji dla środowiska naturalnego
Authors: Borusiak Barbara , Kucharska Barbara
Published: November 2020

The purpose of the paper is to recognize consumers’ opinions on the environmental aspects of meat consumption and the intention to limit meat consumption due to the negative influence of meat production on the environment. The objective of the paper was achieved through literature studies, information acquired from industry magazines and direct research. We adopted the research question whether consumers are willing to limit meat consumption due to the awareness of the consequences of meat consumption for the environment. The research was carried out in December 2019 using the online survey technique. The participants of the study were 457 representatives of young consumers — representatives of the generation which is most convinced of the harmful impact of mankind on the natural environment. The results of the research and analysis indicate that a significant proportion of young consumers have already reduced their meat consumption and a relatively significant (approx. 40%) intend to reduce meat consumption for environmental reasons, with the percentage of people who perceive the negative impact of industrial meat production on the environment is even higher and equals about 50%. Slightly less, approx. 35%, believe that limiting meat consumption can improve the state of the natural environment.
Respondent’s Characteristic and Noise Intensity as Predicting Factors of Noise Induced Hearing Loss
Authors: Situngkir Decy , Ayu Ira Marti , Sipahutara Laosma
Published: November 2020

Introduction: Sensorineural hearing loss caused by loud noise exposure for a long time is known as the risk ofexperiencing Noise-Induced Hearing Loss. PT. Multi Karya Asia Pacific Raya (PT. MKAPR) is a company that provides products and services to the oil and gas industry in Indonesia. Based on its medical check-up, workshop workers at PT MKAPR have the risk of experiencing Noise-Induced Hearing Loss. The Lodan-9 Workshop area was known to have different noise levels, 88-91 dB in the fabrication, pump and engineering areas, and 90-102 dB in the function test area. The purpose of this study was to identify predicting factors of Noise-Induced Hearing Loss at PT. MKAPR. Method: This study used a case-control design. The population in this study were 26 cases and 48 control. Sample size in this study consisted of 26 cases and 26 control. We used a purposive technique sampling. Data were collected through questionnaire, and then were analyzed by using Chi-Square Test. Result: There were association between noise intensity (P-value: 0.035 OR: 4.714; 95% CI: 1.266-17.561), and work period (P-value: 0.029; OR 5.622; 95% CI: 1.342-23.55) with the incidence of Noise-Induced Hearing Loss. Meanwhile age of workers (P-value: 1; OR: 1.547; 95% CI: 0.336-2.976) and smoking habits (P-value: 0.465; OR: 0.435; 95% CI: 0.096-1.168) have no relationship with the incidence of Noise-Induced Hearing Loss. Conclusion: Noise intensity and work period were predictors of Noise-Induced Hearing Loss on PT.MKAPR’ workers. The longer the workers work in high noise intensity area, the more they are at risk of experiencing Noise-Induced Hearing Loss.Keywords: ear, noise-induced hearing loss, noise, noise intensity
The Analysis of Differences in Body Temperature and Blood Pressure Before and After Exposure to Hot Work Climates
Authors: Rahma Sarah Nadhila , Safitri Mahfiro Risky , Tualeka Abdul Rohim
Published: November 2020

Introduction: Working in a hot work environment has a negative impact on occupational health and safety. The impact on health due to work at temperatures above a comfortable temperature can affect body temperature and blood pressure of workers. The aim of this study was to analyze the differences in body temperature and blood pressure of workers before and after exposure to hot work climates at PT. Pertamina (Persero) Tanjung Wangi. Method: This research was an observational study with cross sectional approach. The population of this study was all workers at PT. Pertamina (Persero) Tanjung Wangi., with the total of 11 people. The sample in this study was obtained by total sampling method with a sample of 11 workers. The dependent variables in this study were body temperature, blood pressure, age, fluid intake, and nutritional status, while the independent variable was work climate. Results: Most of the grass lathe workers at PT. Pertamina (Persero) Tanjung Wangi has an age between 17-25 years, some of the grass lathe workers had a fluid intake with less categories with normal nutritional status. The measurement results showed that the average ISBB value was 28.8°C, this value still exceeded TLV. In addition, the results showed that there were differences in body temperature before and after work, from 36.04° C to 36.8° C. In addition there were differences in systolic and diastolic blood pressure before work which was 112.7 mm Hg 77.3 mm Hg, and the average after work was 121 mm Hg and 83.6 mm Hg. Conclusion: There is a difference between body temperature and blood pressure before and after exposure to hot work climates.Keywords: blood pressure, body temperature, hot work climate
The Challenges of Microentrepreneurship Tourism as a New Tourism Destination in Surabaya
Authors: Reindrawati Dian Yulie
Published: November 2020

This research is conducted due to the existence of new tourism destinations in Surabaya, such as Taman Cahaya, Taman Harmoni and Mangrove Gunung Anyar. The existence of the tourism destinations above gives positive impacts on the community to participate in providing the tourism industry through tourism microentrepreneurship. The objective of this research is to explore the challenges from microentrepreneurship in running the business as a new tourism destination. The method used in this research is qualitative research method with descriptive approach. According to the research results, it is concluded that a new tourism is able to create new opportunities to the community to start a new business with the ideas that the development of tourism will result to more visitors and more money spent by them in the tourism destination. This shows that tourism sector is able to increase the opportunities in starting and developing their own business. The challenges in running microentrepreneurship in tourism areas are influenced by various factors, such as lack of awareness in learning and developing the knowledge with regards to the current business and the business products have not been partnering with online transportation companies in their products development. In Mangrove area, the management of the business vendors seems not well-managed as it can be seen from the absence of food corner and stalls, instead, street vendors are dominating the area. This issue is caused by the lack of financial as well as service supports both from the government and private sectors. The tourism development is considered as the best solution in the tourism area in order to accommodate the tourist needs. As a result, more tourists will visit the area and it will enable the community around the area to increase their economic level. The supports from government and private sectors are also needed to educate microentrepreneurship in developing and promote their products widely.
Differences in Marketing Communication Activities at Sheraton Surabaya Hotel & Towers in the middle of COVID-19 Pandemic
Authors: Nata Jiwangga Hadi , Suriani Nur Emma , Darmawan M Riza
Published: November 2020

The tourism industry is a growing industry where hospitality is an essential business that provides accommodation for tourists. However, in early 2020 there was a COVID-19 pandemic that affected the crisis in the tourism industry. The decline in the number of tourists and the limited tourism activities lead to a decrease in consumer buying interest and here also the role of the marketing communication department as a department that promotes and is a liaison between hotels and consumers. The role of marketing communication in increasing the buying interest of prospective consumers is one of the factors that has an impact because of the activities of the department that exchange information with potential customers. This study aims to determine the promotion and adaptation activities carried out by the marketing communication of the Sheraton Surabaya Hotel & Towers in facing a crisis due to the COVID-19 pandemic. In this study, researchers used qualitative methods where the data were analyzed first then arranged and explained with certain statements in the form of written or oral words from an informant and observing the place under study. The results of the study show that marketing communication department of the Sheraton Surabaya Hotel & Towers is adapting to crisis management and using soft selling while planning steps to be taken after the crisis has passed. Marketing communication activities also help to maintain the buying interest of potential customers. The results also show that the use of promotion through social media is more flexible in various conditions.
FARKLI MESLEKLERDE BAŞARILI KİŞİLERİN DÜŞÜNME VE KARAR VERME STİLLERİNİN ÇEŞİTLİ DEĞİŞKENLER AÇISINDAN İNCELENMESİ
Authors: GÜMÜŞER Begüm , UYSAL Öykü Cemre , AYVERDİ Leyla
Published: November 2020

Çalışmanın amacı, farklı mesleklerde başarılı kişilerin düşünme stilleri ile karar verme stilleri arasındaki ilişkiyi ortaya koymak ve düşünme stilleri ile karar verme stillerini cinsiyet ve meslek grubu değişkenleri açısından incelemektir. Araştırma ilişkisel tarama modelinde yürütülmüş olup; çalışma grubu, amaçlı örnekleme yöntemlerinden kartopu örnekleme yöntemi ile seçilen 184 kişiden oluşturmaktadır. Veri toplama aracı olarak Sternberg-Wagner Düşünme Stilleri Ölçeği (SWDSÖ) ve Melbourne Karar Verme Ölçeği I-II (MKVÖ I-II) kullanılmıştır. Veriler, SPSS 22 programı ile analiz edilmiştir. Sonuçlar, farklı mesleklerde başarılı kişilerin düşünme stilleri ve karar verme stilleri arasında anlamlı ilişkiler olduğunu ortaya koymuştur. Mesleğinde başarılı kişilerin düşünme ve karar verme stillerinde, cinsiyet açısından istatistiksel olarak anlamlı sonuçlar ortaya çıkmıştır. Farklı mesleklerde başarılı kişilerin düşünme stillerinde meslek grubuna göre anlamlı farklar olduğu belirlenmiştir.
Synthesis, Characterisation, Antimicrobial activity and DNA
Cleavage of (E)-2-((Tetrazolo[1,5-A]Quinolin-4-
ylmethylene)Amino)Phenol Schiff base Metal complexes
Authors: Ambala Anilkumar , Lincoln Ch. Abraham
Published: November 2020

A series of novel (E)-2-((Tetrazolo[1,5-a]quinolin-4-ylmethylene)amino)phenol
Cu(II), Co(II), Ni(II), Zn(II) and Mn (II) metal complexes have been synthesized 1:1 metal to
ligand ratio, and these complexes were characterized by using analytical data such as FT-IR,
UV-visible, Mass spectroscopy, SEM, EDX, TGA and magnetic moment measurements. The
ligand and all the metal complexes were tested in vitro antimicrobial activity and DNA
cleavage studies.
A Salter-Harris II Distal Radius Fracture Irreducible by Closed Methods
Authors: Carlone Andrew , Kopiec Adam , Riley Scott , Prusick Vincent
Published: November 2020

Case:

A 10-year-old boy presented with a Salter-Harris II distal radius fracture that was irreducible by closed methods. An open reduction was performed in the operating room where a sleeve of periosteum was found interposed between the fracture fragments. Successful reduction was performed without difficulty after the periosteum was removed from the fracture.

Conclusion:

Soft-tissue interposition must be kept in mind when having difficulty performing closed reductions of pediatric distal radius physeal fractures to avoid excessive reduction attempts.
IMPLEMENTATION OF PROJECT ORIENTED PROBLEM-BASED LEARNING (POPBL) MODEL INTEGRATED WITH STEM TO ENHANCE JUNIOR HIGH SCHOOL STUDENTS' SCIENCE CONCEPT MASTERY
Authors: Eliyawati Eliyawati , Sanjaya Yayan , Ramdani A S
Published: November 2020

The low ability of students to solve problems is in line with the low mastery of science concepts. In this study, Science, Technology, Engineering, and Mathematics (STEM) integrated Project Oriented Problem Based Learning (POPBL) learning models were implemented to improve the mastery of science concepts of junior high school students, especially on the topic of Environmental Pollution. The method used was a mixed-method. The STEM integrated STB learning model design framework consists of 3 stages: Onset Stage, Execution Stage, and Closure Stage. The concept of students is emphasized at the onset stage in the case study dissemination phase. In this phase, students analyze problems based on articles provided by the teacher. The more understanding the material, the more critical students will explore existing issues and find logical solutions to those problems. The results showed that there was a difference between the average pretest and posttest learning outcomes (t=-5,660; df = 53; Sig. (2-tailed) = 0,000). This indicates an increase in junior high school students' science concepts mastery after using the STEM integrated POPBL Learning Model. Improving students' mastery of concepts using a STEM integrated POPBL learning model is still in the low category with n-gain = 0.17. Although still in the low category, the POPBL learning model with the STEM approach can be optimized to improve students' mastery of concepts and skills on other science topics.
A risk score based on pediatric Sequential Organ Failure Assessment predicts 90-day mortality in children with Klebsiella pneumoniae bloodstream infection
Authors: Li Shuang , Liu Jingxian , Chen Feng , Cai Kang , Tan Jintong , Xie Wei , Qian Rong , Liu Xiaoqin , Zhang Wenhong , Du Huimin , Liu Ying , Huang Lisu
Published: November 2020

Background: Klebsiella pneumoniae bloodstream infection (Kp-BSI) is a serious threat to pediatric patients. The objective of this study was to explore the risk factors, validate the prediction efficiency of pediatric Sequential Organ Failure Assessment (SOFA) and establish better early predictors of mortality in pediatric patients with Kp-BSI.Methods: All children diagnosed with Kp-BSI were included in this retrospective cohort study from January 2009 to June 2019. Basic characteristics, symptoms and physical examinations, treatments, laboratory statistics, and SOFA at the onset of Kp-BSI were recorded. The Cox proportional hazard model and receiver operating characteristic curves were used to assess the association between the variables and the 90-day mortality and their predictive value. DeLong’s test of receiver operating characteristic curves and integrated discrimination improvement index were used to determine the improvement in predictive capacity of the modified SOFA models. A predictive score was developed using multivariate logistic regression.Results: Of the 146 children enrolled, 33 (22.6%) patients died within 90 days. Hospitalization in the last six months, intra-abdominal source of infection, presence of organ failure, and altered levels of blood biomarkers, including C-reactive protein, albumin, and lactate were significant risk factors for 90-day mortality. The area under the curve (AUC) of SOFA for predicting 90-day mortality was 0.80 (95% CI 0.71–0.89). Moreover, we found that a prediction model combining SOFA with two other parameters, namely hospitalization in the last six months and intra-abdominal source of infection, was better at predicting mortality (AUC = 0.89, 95% CI 0.82–0.96; sensitivity = 0.86; specificity = 0.84). According to this novel risk model, we defined three statistically different groups: low-risk, medium-risk and high-risk groups, with an observed 90-day mortality of 5.4%, 35.7%, and 72.0%, respectively. With reference to the low-risk patients, the medium-risk and high-risk groups had a higher mortality, with hazard ratios of 8.36 (95% CI 3.60–27.83) and 20.27 (95% CI 7.47–54.95), respectively.Conclusions: The modified SOFA may be better than the original score to predict 90-day mortality in pediatric patients with Kp-BSI. Future prospective studies are required to validate this novel scoring system in external cohorts.
Estimating Remaining Carbon Budgets Using Emulators of CMIP6 Models
Authors: Rypdal Martin , Boers Niklas , Fredriksen Hege-Beate , Eiselt Kai-Uwe , Johansen Andreas , Martinsen Andreas , Mentzoni Endre Falck , Graversen Rune , Rypdal Kristoffer
Published: November 2020

A remaining carbon budget (RCB) estimates how much CO2 we can emit and still reach a specific temperature target. The RCB concept is attractive since it easily communicates to the public and policymakers, but RCBs are also subject to uncertainties. The expected warming levels for a given carbon budget has a wide uncertainty range, which we show here to increase with less ambitious targets, i.e., with higher CO2 emissions and temperatures. We demonstrate that the leading cause of the revealed RCB uncertainty is the spread in the equilibrium climate sensitivity (ECS) among climate models. In the Coupled Model Intercomparison Project Phase 6 (CMIP6) ensemble, the models with the lower ECS predict an RCB that is twice as high as that of models with the higher ECS, for temperature targets between 1.5-3.0°C.
Unify Language and Vision: An Efficient COVID-19 Tomography Image
Classification Approach
Authors: Shen Dezhou
Published: November 2020

An accurate and efficient image classification algorithm used in the COVID-19 detection for lung tomography can be of great help for doctors working in places without advance equipments. The machine with high accuracy COVID-19 classification model can relief the burden by making testing and checking thousands of people’s tomography images easy for a specific region which suffers from the COVID-19 outbreak incidents. By encoding image pixels and meta-data using the pre-trained language models of Bidirectional Encoder Representations from Transformers, then connect to a fully connected layer, the classification model outperforms the ResNet model and the DenseNet image classification model, and achieved accuracy of 99.51% ∼ 100.00% on the COVID-19 tomography image test set.
Machine learning magnetic resonance imaging radiomics predicts axillary lymph node metastasis in invasive breast cancer
Authors: Yu Yunfang , He Zifan , Ouyang Jie , Tan Yujie , Chen Yong-Jian , Gu Yang , Mao Luhui , Wang Jue , Ren Wei , Lin Lili , Wu Zhuo , Liu Jingwen , Li Anlin , Ou Qiyun , Hu Qiugen , Chen Kai , Li Chenchen , Lu Nian , Li Xiaohong , Su Fengxi Su , Liu Qiang , Xie Chuan-Miao , Yao Herui
Published: November 2020

In current clinical practice, the standard evaluation for axillary lymph node (ALN) status in breast cancer is based on the invasive procedure and many patients will suffer from operative associated complications. Hence, a novel signature incorporated tumor and lymph node magnetic resonance imaging (MRI) radiomics, clinical and pathological characteristics, and molecular subtypes based on the machine learning approach was established to accurately identify ALN metastasis in early-stage invasive breast cancer patients. Although the misjudgment of ALN status by clinicians according to preoperative MRI are common during clinical practice and even the senior radiologists make mistakes sometimes, this multiomic radiomic signature showed the superiority over clinicians and could precisely discriminate ALN metastasis among different molecular subtype patients. Furthermore, the association between MRI radiomic features and tumor-microenvironment features including immune cells, long non-coding RNAs, and types of methylated sites were found, which revealed the potential biological underpinning of MRI radiomics.
Electro-Mechanical Stresses on Bacillus Atrophaeus Bacterial Spore Germination Induced by Pulsed Electric Fields
Authors: Qiu Xing , WU Wen Jie
Published: November 2020

In this work, the electro-mechanical stresses induced by pulsed electric fields (PEF) on bacterial spore germination was modeled and empirically tested using Bacillus atrophaeus spores. Specifically, a new model, termed as Qiu-Wu’s electro-mechanical (QW’s EM) spore model, was derived to analyze the effect of electro-mechanical stresses on spores subjected under electric fields. A non-linear inverse relationship was found between electric fields and thickness change of spore coat. SEM, pH, hydrophobicity and electrochemical measurements were implemented for verification of the model. PEF-treated spores germinated with a faster rate and a higher degree of homogeneity. The longer the treatment time, the better the homogeneity. The speed of dipicolinic acid (DPA) release was around 20% faster in PEF-treated samples, while the peak intensity of terbium-DPA from PEF-treated samples was up to 80% lower. Theoretical analysis and empirical results were consistent to show that PEF introduces electro-mechanical stresses to expedite spore germination. The significance and impact of this study is obvious: bacterial spore is implicated in food spoilage and foodborne diseases primarily via the process of germination, and PEF technology has been introduced to inactivate microorganisms in food. Understanding the mechanism of germination under PEF can provide deep understanding for inactivation of foodborne pathogens and better food preservation methods.
SARS-CoV-2 induced CYP19A1 expression in the lung correlates with increased aromatization of testosterone-to-estradiol in male golden hamsters
Authors: Stanelle-Bertram Stephanie , Schaumburg Berfin , Kouassi Nancy Mounogou , Beck Sebastian , Zickler Martin , Beythien Georg , Becker Kathrin , Bai Tian , Jania Hanna , Müller Zacharias , Reis Vinicius Pinho dos , Krump-Buzumkic Vanessa , Kadek Alan , Uetrecht Charlotte , Schroeder Maria , Jarczak Dominik , Nierhaus Axel , Kluge Stefan , Scaturro Pietro , Baumgärtner Wolfgang , Klingel Karin , Guelsah Gabriel
Published: November 2020

SARS-CoV-2 infection is associated with increased morbidities in men compared to women. Androgens are believed to play an important role in SARS-CoV-2 pathogenesis in men due to the postulated androgen-dependency of ACE2 and TMPRSS2. However, it is yet unclear whether the sex bias is mediated by SARS-CoV-2 infection itself or by other confounding factors. Here, using the golden hamster model, we show that SARS-CoV-2 infection attacks reproductive organs, causes massive dysregulation of sex hormones and induces elevated transcription of the androgen-to-estrogen converting enzyme aromatase CYP19A1 in the lung. In male hamsters, SARS-CoV-2 infection causes severely depleted testosterone and highly elevated estradiol levels. In female hamsters, SARS-CoV-2 infection causes reduced estradiol levels. Hormonal dysregulation in infected animals is followed by severe weight loss compared to control groups treated with poly(I:C) or PBS. Lungs of SARS-CoV-2 infected animals present abundant CYP19A1 expression in the endothelium and in macrophages, particularly in males. Prominent CYP19A1 expression in endothelial cells and macrophages was verified in lung sections of deceased Covid-19 males compared to females. Our results demonstrate that SARS-CoV-2 infection leads to massive dysregulation of sex hormones, which may increase the risk for sex-specific disease outcome particularly in combination with comorbidities. These findings provide insights into the complex metabolic cross talk between SARS-CoV-2 infection and sex hormones.