bluuebunny/crossref_metadata_2025 huggingface dataset:
Complementary Coarse-to-Fine Matching for Video Object Segmentation
Authors: Chen Zhen , Yang Ming , Zhang Shiliang
Published: May 2023

Semi-supervised Video Object Segmentation (VOS) needs to establish pixel-level correspondences between a video frame and preceding segmented frames to leverage their segmentation clues. Most works rely on features at a single scale to establish those correspondences, e.g., perform dense matching with Convolutional Neural Network (CNN) features from a deep layer. Differently, this work explores complementary features at different scales to pursue more robust feature matching. A coarse feature from a deep layer is first adopted to get coarse pixel-level correspondences. We hence evaluate the quality of those correspondences, and select pixels with low-quality correspondences for fine-scale feature matching. Segmentation clues of previous frames are propagated by both coarse and fine-scale correspondences, which are fused with appearance features for object segmentation. Compared with previous works, this coarse-to-fine matching scheme is more robust to distractions by similar objects and better preserves object details. The sparse fine-scale matching also ensures a fast inference speed. On popular VOS datasets including DAVIS and YouTube-VOS, the proposed method shows promising performance compared with recent works.
Sensing within Smart Buildings: A Survey
Authors: Alsafery Wael , Rana Omer , Perera Charith
Published: May 2023

Increasingly, buildings are being fitted with sensors for the needs of different sectors, such as education, industry and business. Using Internet of Things devices combined with analysis of data being generated by these devices, it is possible to infer a number of metrics, e.g., building occupancy and activities of occupants. The information thus gathered can be used to develop software applications to support energy management, occupant comfort, and space utilization. This survey explores the use of sensors in smart building environments, identifying different approaches to employ sensors in buildings. The most commonly used data-driven approaches for activity recognition in such buildings is also investigated, concluding by highlighting current research challenges and future research directions in this area.
Multimodal Social Data Analytics on the Design and Implementation of an EEG-Mechatronic System Interface
Authors: Aume Cameron , Pal Shantanu , Jolfaei Alireza , Mukhopadhyay Subhas
Published: May 2023

The devices that can read Electroencephalography (EEG) signals have been widely used for Brain-Computer Interfaces (BCIs). Popularity in the field of BCIs has increased in recent years with the development of several consumer-grade EEG devices that can detect human cognitive states in real-time and deliver feedback to enhance human performance. Several previous studies have been conducted to understand the fundamentals and essential aspects of EEG in BCIs. However, the significant issue of how consumer-grade EEG devices can be used to control mechatronic systems effectively has been given less attention. In this article, we have designed and implemented an EEG BCI system using the OpenBCI Cyton headset and a user interface running a game to explore the concept of streamlining the interaction between humans and mechatronic systems with a BCI EEG-mechatronic system interface. Big Multimodal Social Data (BMSD) analytics can be applied to the high-frequency and high-volume EEG data, allowing us to explore aspects of data acquisition, data processing, and data validation and evaluate the Quality of Experience (QoE) of our system. We employ real-world participants to play a game to gather training data that was later put into multiple machine learning models, including a linear discriminant analysis (LDA), k-nearest neighbours (KNN), and a convolutional neural network (CNN). After training the machine learning models, a validation phase of the experiment took place where participants tried to play the same game but without direct control, utilising the outputs of the machine learning models to determine how the game moved. We find that a CNN trained to the specific user was able to control the game and performed with the highest activation accuracy from the machine learning models tested, along with the highest user-rated QoE, which gives us significant insight for future implementation with a mechatronic system.
Catalytic Activity and Stability of Non-Platinum Group Metal Oxides for the Oxygen Evolution Reaction in Anion Exchange Membrane Electrolyzers
Authors: Volk Emily K. , Kwon Stephanie , Alia Shaun M.
Published: May 2023

The activities and stabilities of non-platinum group metals (PGMs) in the forms of monometallic (Mn2O3, Fe2O3, Co3O4, NiO) and bimetallic (NiFe2O4, CoNiO2) oxides were assessed for the oxygen evolution reaction (OER) in alkaline media and compared with IrO2. Both half-cell, rotating disc electrode (RDE) apparatus and single-cell, membrane electrode assemblies (MEA) were used to study kinetic and device-level performance in parallel and to provide insights into the use of these materials in anion exchange membrane (AEM) electrolyzers. Normalization of RDE results by geometric and physical surface areas, double layer capacitance, and metal content probed differences in physically vs electrochemically accessible surface areas and ensured reported trends were independent of the normalization method. The results showed that: (i) Ni- and Co- containing materials met or exceeded IrO2 performance in both RDE and MEA testing, (ii) Co3O4 deactivated over time-on-stream (1.8 V for 13.5 h) due to oxide and, relatedly, particle growth, (iii) NiFe2O4 increased in activity over time-on-stream due to dissolution of Fe and an increased Ni/Fe ratio, and (iv) reduction of catalyst layer resistance is an avenue to further increase device-level performance. These results demonstrated the clear viability for non-PGMs to be used as anode catalysts in AEM devices.
Use of Multielectrode Arrays and Statistical Analysis to Investigate the Pitting Probability of Copper: Part II. The Effect of Sulfate and Bicarbonate
Authors: Matin Sina , Morgan Adam , Tahmasebi Arezoo , Zadidulin Dmitrij , Behazin Mehran , Davison Matt , Shoesmith David W. , Noël James J.
Published: May 2023

Copper and copper alloys have found applications in various industries. One of the main reasons Cu and its alloys are utilized widely is that they have sufficient corrosion resistance in key environments, such as seawater and anoxic solutions; however, localized corrosion processes might occur in the presence of aggressive anions, oxygen, or an increase in solution pH. In critical applications of Cu, the susceptibility of Cu to localized corrosion, specifically pitting, must be carefully considered, as it could lead to material failure. In this study, the pitting probability of Cu in unary (sulfate) and binary (sulfate + bicarbonate) solutions was investigated using electrochemical techniques in conjunction with statistical analysis. We determined pitting probabilities based on two different defining criteria for pitting susceptibility, one based on the probability that the corrosion potential, Ecorr, could exceed the passivity breakdown potential, Eb, and the other, a more conservative approach, based on the likelihood that Ecorr would be greater than the repassivation potential, Erp. The pitting probability of Cu did not change significantly with sulfate concentration at pH 8 but was found to increase with increasing [

SO

4

2
−

] up to 0.005 M at pH 9 and then to decrease with a further increase in [

SO

4

2
−

].
Properties of Electro-Deposited CuSCN Thin Films with Different Electrodeposition Charge Density
Authors: Huang Yu-Tang , Wang Li-Wen , Tang Jian-Fu , Wu Tai-Yu , Liu Yi-Hung , Chu Sheng-Yuan
Published: May 2023

The development of efficient CuSCN hole transport layers is crucially important for achieving high photovoltaic performance in inorganic perovskite devices. In this study, the effects of electrodeposition charge density on the morphological/microstructural and electrical properties and the formation mechanism of electro-deposited CuSCN films are investigated and discussed. The results indicate that the charge density is the key factor that governs not only the thickness, but also morphological, electrical, and surface properties of the electro-deposited CuSCN films. For the energy band diagram property, we found that when the charge density is 120 mC cm−2 (named as CD120), the valance band of CuSCN near ITO work function. This excellent property can efficiently improve the photovoltaic performance of inorganic perovskite devices, where ITO and CuSCN are employed, owing to the reduction of energy barrier. Among the films electro-deposited at different charge densities, the CD120 exhibits the highest mobility, possibly due to the excess amount of SCN in the thin film.
Modeling and Analysis of Stochastic Perishable Inventory System with Impatient Customers at Service Facility
Authors: Islam Md. Amirul , Ekramol Islam Mohammad , Rashid Abdur
Published: May 2023

In this paper, we consider a two‐commodity stochastic (s, S) perishable inventory system of the multiqueue Jackson network at a service facility with reneging and jockeying of the customers. The waiting room capacity of the first queue is M/M/1/∞ and the second queue is M/M/1/C2, where C2 < ∞. In this network, different queues have different service rates. Service times are exponentially distributed. Customers join the system at a rate of λi; (i = 1,2) using a Poisson process. We assumed that some customers maybe impatient due to the long waiting time in the queue and can leave the system without service or may switch from the longest queue to the shortest queue to reduce the waiting time. If the inventory levels of the items from the warehouse i at any time reaches below or reorder level si, an order Qi = ((Si − si) > 0; i = 1,2) units is placed to bring the inventory level up to Si. The joint probability distribution of the number of customers in the system and also the stock level of the warehouse is determined in the equilibrium case. Several important measures of steady‐state system performance are derived. Several examples are presented to demonstrate the reneging and jockeying behavior of the customers for this system. A sensitivity analysis is performed to investigate the effect of changing the parameters on the total expected cost of the system.
Dermoscopic Features of Psoriatic Nails and Their Correlation to Disease Severity
Authors: Mashal Zeinab R. , Elgamal Emad Eldin A. , Zaky Mohamed S. , Elsaie Mohamed L.
Published: May 2023

Background. Nail psoriasis is a challenging chronic condition affecting patients functionally and psychologically. Nail involvement is observed in 15–80% of psoriatic patients with occasional presence of isolated nail psoriasis. Objectives. To evaluate dermoscopic features of nail psoriasis and correlate them clinically. Methods. The study included fifty subjects with nail psoriasis. Psoriasis skin and nail severity was evaluated using psoriasis area severity index (PASI) and nail psoriasis severity index (NAPSI). Dermoscopy of the nails (onychoscopy) was performed, and features were recorded and analyzed. Results. The most common clinical and dermoscopic findings were pitting (86%) and onycholysis (82%). Among all dermoscopic features of nail psoriasis, only longitudinal striations and subungual hyperkeratosis were significantly higher in patients with moderate to severe psoriasis than in patients with mild psoriasis (

P
=
0.028

;

P
=
0.042

, respectively). PASI scores correlated positively but none significantly with NAPSI scores (r = 0.132,

P
=
0.360

), and similarly, no significant correlation was observed between the duration of psoriasis and the dermoscopic NAPSI (r = 0.022,

P
=
0.879

). Conclusion. Dermoscopy can serve as a useful tool for early diagnosis of psoriatic nail changes not always visible to the naked eye and is a non-invasive easy-to-use confirmatory tool for nail changes in psoriatic disease or in isolated nail involvement.
Renoprotective Effect of Thai Patients with Type 2 Diabetes Mellitus Treated with SGLT-2 Inhibitors versus DPP-4 Inhibitors: A Real-World Observational Study
Authors: Chanawong Apichaya , Uitrakul Suriyon , Incomenoy Supatcha , Poonchuay Natnicha
Published: May 2023

Background. Recently, there is a lack of studies comparing the renoprotective effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors. This study therefore aimed to investigate the renoprotective effects of SGLT-2 inhibitors and DPP-4 inhibitors on Thai patients with type 2 diabetes mellitus. Methods. Patient medication records of all patients who used those two antidiabetic classes at Fort Wachirawut Hospital were reviewed. Renal function tests, blood glucose levels, and other baseline characteristics were collected. Continuous variables were compared within the group using the Wilcoxon signed-rank test and between groups using the Mann–Whitney U test. Results. There were 388 and 691 patients with SGLT-2 inhibitors and DPP-4 inhibitors, respectively. The mean estimated glomerular filtration rate (eGFR) of the SGLT-2 inhibitor group was significantly lower from baseline at 18 months of treatment, as well as the DPP-4 inhibitor group. However, the trend of eGFR reduction in patients with baseline eGFR <60 mL/min/1.73 m2 was smaller than those with baseline eGFR ≥60 mL/min/1.73 m2. In addition, the fasting blood sugar and haemoglobin A1c levels significantly decreased from baseline in both the groups. Conclusions. Both SGLT-2 inhibitors and DPP-4 inhibitors showed the same trends of eGFR reductions from baseline in Thai patients with type 2 diabetes mellitus. However, SGLT-2 inhibitors should be considered in patients with impaired renal function rather than in all T2DM patients.
Changes in Protease-Activated Receptor and Trypsin-1 Expression Are Involved in the Therapeutic Effect of Mg2+ Supplementation in Type 2 Diabetes-Induced Gastric Injury in Male Adult Rats
Authors: Mehranfard Nasrin , Rezazadeh Hossein , Soltani Nepton , Dastgerdi Azadesadat Hosseini , Ghanbari Rad Mahtab , Ghasemi Maedeh
Published: May 2023

Purpose. Gastric inflammation is common and usually severe in patients with type 2 diabetes mellitus (T2DM). Evidence suggests protease-activated receptors (PARs) are a link between inflammation and gastrointestinal dysfunction. Given that magnesium (Mg2+) deficiency is a highly prevalent condition in T2DM patients, we assessed the therapeutic role of Mg2+ on the factors involved in gastric inflammation in T2DM. Methods. A rat model of T2DM gastropathy was established using a long-term high-fat diet + a low dose of streptozocin. Twenty-four rats were divided into control, T2DM , T2DM + insulin (positive control), and T2DM + Mg2+ groups. At the end of 2-month therapies, changes in the expression of gastric trypsin-1, PAR1, PAR2, PAR3, PI3K/Akt, and COX-2 proteins were measured by western blot. Hematoxylin and eosin and Masson’s trichrome staining were used to detect gastric mucosal injury and fibrosis. Results. The expression of trypsin-1, PAR1, PAR2, PAR3, and COX-2 increased in diabetes, and Mg2+/insulin treatment strongly decreased their expression. The PI3K/p-Akt significantly decreased in T2DM, and treatment with Mg2+/insulin improved PI3K in T2DM rats. Staining of the gastric antrum tissue of the insulin/Mg2+-treated T2DM rats showed a significantly minimal mucosal and fibrotic injury compared with those of rats from the T2DM group. Conclusion. Mg2+ supplement, comparable to insulin, via decreasing PARs expression, mitigating COX-2 activity, and decreasing collagen deposition could exert a potent gastroprotective effect against inflammation, ulcer, and fibrotic development in T2DM patients.
Effect of Zingiber officinale on Lipid Profile and Some Inflammatory Markers in Diabetic Hemodialysis Patients: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial
Authors: Veisi Parisa , Rostamkhani Helya , Niknafs Bahram , Asghari Jafarabadi Mohammad , Ghoreishi Zohreh
Published: May 2023

Background. Diabetes, inflammation, and abnormal lipid levels are the main risk factors for mortality in end‐stage renal disease (ESRD). The present study aimed to investigate the effects of ginger supplementation on inflammatory markers and lipid profile in diabetic patients with ESRD undergoing hemodialysis. Methods. In this study, 44 patients were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 2000 mg/d ginger for eight weeks, while the control group received the placebo with the same protocol. The serum concentrations of triglyceride (TG), total cholesterol (TC), low‐density lipoprotein‐cholesterol (LDL‐c), high‐density lipoprotein‐cholesterol (HDL‐c), albumin, and high‐sensitivity C‐reactive protein (hs‐CRP) were measured after a 12‐ to 14‐hours fast at the baseline and the end of the study, as along with the platelet‐to‐lymphocyte ratio (PLR), neutrophil‐to‐lymphocyte ratio (NLR), and Glasgow prognostic score (GPS). Results. Forty‐one subjects were analyzed based on the intention‐to‐treat method of all included patients. Serum levels of TG (p = 0.003), hs‐CRP (p = 0.022), and NLR (p = 0.001) decreased significantly in the ginger group compared to the placebo group, while albumin concentration in serum was elevated (p = 0.022). However, there were no significant differences in GPS, levels of TC, LDL‐C, HDL‐C, and PLR within and between the groups (p > 0.05). Conclusion. Ginger administration reduced NLR, hs‐CRP, and TG serum levels and increased serum albumin levels in included patients. Thus, ginger can be considered an effective complementary treatment for these patients. This trail is registered with IRCT20191109045382N3.
On the Optimal Control of Intervention Strategies for Hepatitis B Model
Authors: Atte Momoh Abdulfatai , Audu Abubakar , Dione Déthié , Ali Inalegwu Michael
Published: May 2023

Hepatitis B is one of the leading causes of morbidity and mortality, affecting hundreds of millions of people worldwide. Thus, this paper focuses on three control measures as the best way to intervene against the hepatitis B viral infection. These measures are condom use, testing and treatment, and vaccination to stop the disease from spreading over a community. The model comprises seven (7) compartments that include susceptible individuals, latent individuals, acute-infected individuals, chronic-infected individuals, infected by carrier individuals, recovered individuals from the disease, and the vaccinated population. We mathematically established a nonlinear differential equation to study the dynamics of the model. The disease-free equilibrium (DFE) and endemic equilibrium (EE) are reached. The basic reproduction numbers,

R

0

A

,

R

0

H

, and

R

0

C

, determine the transmission of the disease and thus are gotten. We perform sensitivity analysis on the reproduction numbers to identify the factors that affect the reproduction numbers. The results of the sensitivity analysis paved a way for introducing a controlled system which was solved using Pontryagin’s maximum principle (PMP) and the optimality system got. The optimality system was then solved numerically using the forward and backward sweep approach, and graphs were generated, establishing the conditions for local and global stability of the disease-free equilibrium using the Routh-Hurwitz criterion and Castillo-Chavez approach, respectively. We also used Pontryagin’s maximum principle to determine the optimality system. The result of the analysis of the stability of the disease-free equilibrium states that hepatitis B virus can be completely wiped out if the rate of infection is kept at a number less than unity. A numerical simulation of the model was carried out and showed that hepatitis B virus transmission can best be controlled when condom use, testing and treatment, and vaccination are implemented.
Supplementary Table 4 from RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Authors: Compadre Amanda J. , van Biljon Lillian N. , Valentine Mark C. , Llop-Guevara Alba , Graham Emily , Fashemi Bisiayo , Herencia-Ropero Andrea , Kotnik Emilee N. , Cooper Isaac , Harrington Shariska P. , Kuroki L Lindsay M. , McCourt Carolyn K. , Hagemann Andrea R. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Sun Lulu , Mosammaparast Nima , Serra Violeta , Zhao Peinan , Lomonosova Elena , Khabele Dineo , Mullen Mary M.
Published: May 2023

Patient characteristics of FFPE discovery cohort
Supplementary Table 2 from RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Authors: Compadre Amanda J. , van Biljon Lillian N. , Valentine Mark C. , Llop-Guevara Alba , Graham Emily , Fashemi Bisiayo , Herencia-Ropero Andrea , Kotnik Emilee N. , Cooper Isaac , Harrington Shariska P. , Kuroki L Lindsay M. , McCourt Carolyn K. , Hagemann Andrea R. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Sun Lulu , Mosammaparast Nima , Serra Violeta , Zhao Peinan , Lomonosova Elena , Khabele Dineo , Mullen Mary M.
Published: May 2023

Patient characteristics of patient-derived ovarian cancer cells
Supplementary Figure S4 from RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Authors: Compadre Amanda J. , van Biljon Lillian N. , Valentine Mark C. , Llop-Guevara Alba , Graham Emily , Fashemi Bisiayo , Herencia-Ropero Andrea , Kotnik Emilee N. , Cooper Isaac , Harrington Shariska P. , Kuroki L Lindsay M. , McCourt Carolyn K. , Hagemann Andrea R. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Sun Lulu , Mosammaparast Nima , Serra Violeta , Zhao Peinan , Lomonosova Elena , Khabele Dineo , Mullen Mary M.
Published: May 2023

RAD51 scores in BRCA mutated tumors shows correlation with survival and protein integrity
Supplementary Figure S3 from RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Authors: Compadre Amanda J. , van Biljon Lillian N. , Valentine Mark C. , Llop-Guevara Alba , Graham Emily , Fashemi Bisiayo , Herencia-Ropero Andrea , Kotnik Emilee N. , Cooper Isaac , Harrington Shariska P. , Kuroki L Lindsay M. , McCourt Carolyn K. , Hagemann Andrea R. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Sun Lulu , Mosammaparast Nima , Serra Violeta , Zhao Peinan , Lomonosova Elena , Khabele Dineo , Mullen Mary M.
Published: May 2023

RAD51 expression and platinum chemotherapy response in vitro and in patient tumors
Supplementary Figure S2 from RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Authors: Compadre Amanda J. , van Biljon Lillian N. , Valentine Mark C. , Llop-Guevara Alba , Graham Emily , Fashemi Bisiayo , Herencia-Ropero Andrea , Kotnik Emilee N. , Cooper Isaac , Harrington Shariska P. , Kuroki L Lindsay M. , McCourt Carolyn K. , Hagemann Andrea R. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Sun Lulu , Mosammaparast Nima , Serra Violeta , Zhao Peinan , Lomonosova Elena , Khabele Dineo , Mullen Mary M.
Published: May 2023

γH2AX score in established and patient-derived ovarian cancer cell lines and patient-derived organoids
Supplementary Figure S1 from RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Authors: Compadre Amanda J. , van Biljon Lillian N. , Valentine Mark C. , Llop-Guevara Alba , Graham Emily , Fashemi Bisiayo , Herencia-Ropero Andrea , Kotnik Emilee N. , Cooper Isaac , Harrington Shariska P. , Kuroki L Lindsay M. , McCourt Carolyn K. , Hagemann Andrea R. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Sun Lulu , Mosammaparast Nima , Serra Violeta , Zhao Peinan , Lomonosova Elena , Khabele Dineo , Mullen Mary M.
Published: May 2023

Flow diagram of HGSOC patient-derived samples used for RAD51 foci assay
Table S2 from Novel BCL-2 Inhibitor Lisaftoclax in Relapsed or Refractory Chronic Lymphocytic Leukemia and Other Hematologic Malignancies: First-in-Human Open-Label Trial
Authors: Ailawadhi Sikander , Chen Zi , Huang Bo , Paulus Aneel , Collins Mary C. , Fu Lei (Tommy) , Li Mingyu , Ahmad Mohammad , Men Lichuang , Wang Hengbang , Davids Matthew S. , Liang Eric , Mekala Divya J. , He Zhicong , Lasica Masa , Yannakou Costas K. , Parrondo Ricardo , Glass Laura , Yang Dajun , Chanan-Khan Asher , Zhai Yifan
Published: May 2023

Summary of BH3 profiling for PBMC samples collected at baseline.
Table S1 from Novel BCL-2 Inhibitor Lisaftoclax in Relapsed or Refractory Chronic Lymphocytic Leukemia and Other Hematologic Malignancies: First-in-Human Open-Label Trial
Authors: Ailawadhi Sikander , Chen Zi , Huang Bo , Paulus Aneel , Collins Mary C. , Fu Lei (Tommy) , Li Mingyu , Ahmad Mohammad , Men Lichuang , Wang Hengbang , Davids Matthew S. , Liang Eric , Mekala Divya J. , He Zhicong , Lasica Masa , Yannakou Costas K. , Parrondo Ricardo , Glass Laura , Yang Dajun , Chanan-Khan Asher , Zhai Yifan
Published: May 2023

Representativeness of study participants.
Supplementary Tables S1-S15 from Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors
Authors: Schroers-Martin Joseph G. , Soo Joanne , Brisou Gabriel , Scherer Florian , Kurtz David M. , Sworder Brian J. , Khodadoust Michael S. , Jin Michael C. , Bru Agnès , Liu Chih Long , Stehr Henning , Vineis Paolo , Natkunam Yasodha , Teras Lauren R. , Song Joo Y. , Nadel Bertrand , Diehn Maximilian , Roulland Sandrine , Alizadeh Ash A.
Published: May 2023

Supplementary Table S1. Patient and control clinical characteristics
Supplementary Table S2. Sequencing metrics for FL cases & controls
Supplementary Table S3. Identified mutations in EPIC FL pre-diagnostic samples
Supplementary Table S4. Identified mutations in control samples
Supplementary Table S5. Statistical significance for detection in prediagnostic samples with paired tumor biopsy
Supplementary Table S6. Identified mutations in FL tumors with detection in paired prediagnostic samples
Supplementary Table S7. Paired tumor cohort histology & sample characteristics
Supplementary Table S8. Identified mutations in paired biopsy samples
Supplementary Table S9. Clonal VDJ rearrangements in paired biopsies
Supplementary Table S10. Concordance analysis of paired biopsy samples
Supplementary Table S11. Patient characteristics, marrow and sorting studies
Supplementary Table S12. DNA and sequencing metrics for marrow and sorting studies
Supplementary Table S13. Monoclonal antibodies and manufacturers
Supplementary Table S14. Mutations detected in marrow and sorting studies
Supplementary Table S15. Genes fully or partially covered in lymphoma-focused CAPP-Seq selector
Supplementary Table S4 from Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia
Authors: Nowicki-Osuch Karol , Zhuang Lizhe , Cheung Tik Shing , Black Emily L. , Masqué-Soler Neus , Devonshire Ginny , Redmond Aisling M. , Freeman Adam , di Pietro Massimilliano , Pilonis Nastazja , Januszewicz Wladyslaw , O'Donovan Maria , Tavaré Simon , Shields Jacqueline D. , Fitzgerald Rebecca C.
Published: May 2023

This table contains results of pairwise differential expression analysis between E-GM and gastric tissues and Atrophic gastritis and gastric tissue.
Supplementary Table S1 from Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia
Authors: Nowicki-Osuch Karol , Zhuang Lizhe , Cheung Tik Shing , Black Emily L. , Masqué-Soler Neus , Devonshire Ginny , Redmond Aisling M. , Freeman Adam , di Pietro Massimilliano , Pilonis Nastazja , Januszewicz Wladyslaw , O'Donovan Maria , Tavaré Simon , Shields Jacqueline D. , Fitzgerald Rebecca C.
Published: May 2023

This file contains details of individual samples (including clinical data) used in the sutdy
Data from Tracing founder mutations in circulating and tissue-resident follicular lymphoma precursors
Authors: Schroers-Martin Joseph G. , Soo Joanne , Brisou Gabriel , Scherer Florian , Kurtz David M. , Sworder Brian J. , Khodadoust Michael S. , Jin Michael C. , Bru Agnes , Liu Chih Long , Stehr Henning , Vineis Paolo , Natkunam Yasodha , Teras Lauren R. , Song Joo Y. , Nadel Bertrand , Diehn Maximilian , Roulland Sandrine , Alizadeh Ash A.
Published: May 2023

Abstract
Follicular lymphomas (FL) are characterized by BCL2 translocations, often detectable in blood years before FL diagnosis, but also observed in aging healthy individuals suggesting additional lesions are required for lymphomagenesis. We directly characterized early cooperating mutations by ultra-deep sequencing of pre-diagnostic blood and tissue specimens from 48 subjects who ultimately developed FL. Strikingly, CREBBP lysine acetyltransferase (KAT) domain mutations were the most commonly observed precursor lesions, and largely distinguished patients developing FL (14/48, 29%) from healthy adults with or without detected BCL2 rearrangements (0/13, p=0.03 and 0/20, p=0.007, respectively). CREBBP variants were detectable a median of 5.8 years before FL diagnosis, were clonally selected in FL tumors, and appeared restricted to the committed B-cell lineage. These results suggest that mutations affecting the CREBBP KAT domain are common lesions in FL cancer precursor cells (CPC), with potential for discriminating subjects at risk of developing FL or monitoring residual disease.
Table S1-2 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics
Authors: Wang Siwei , Xia Zhijun , You Jing , Gu Xiaolan , Meng Fanchen , Chen Peng , Tang Wanxiangfu , Bao Hua , Zhang Jingyuan , Wu Xue , Shao Yang , Wang Jie , Zuo Xianglin , Xu Lin , Yin Rong
Published: May 2023

Supplementary Table S1. Patient demography
Supplementary Table S2. Evaluating fragmentomics model performances and ctDNA mutation-based method.
Supplementary Figure S4 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics
Authors: Wang Siwei , Xia Zhijun , You Jing , Gu Xiaolan , Meng Fanchen , Chen Peng , Tang Wanxiangfu , Bao Hua , Zhang Jingyuan , Wu Xue , Shao Yang , Wang Jie , Zuo Xianglin , Xu Lin , Yin Rong
Published: May 2023

Recursive feature elimination with cross-validation of Coxnet model using fragmentomics profiles
Supplementary Figure S3 from Nuclear export inhibitor Selinexor enhances oncolytic myxoma virus therapy against cancer
Authors: Rahman Masmudur M. , Oosterom Fleur van , Enow Junior A. , Hossain Maksuda , Gutierrez-Jensen Ami D. , Cashen Mackenzie , Everts Anne , Lowe Kenneth , Kilbourne Jacquelyn , Daggett-Vondras Juliane , Karr Timothy L , McFadden Grant
Published: May 2023

Tumor burden of individual mouse received PANC-1 cells.
Supplementary Figure S1 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics
Authors: Wang Siwei , Xia Zhijun , You Jing , Gu Xiaolan , Meng Fanchen , Chen Peng , Tang Wanxiangfu , Bao Hua , Zhang Jingyuan , Wu Xue , Shao Yang , Wang Jie , Zuo Xianglin , Xu Lin , Yin Rong
Published: May 2023

Evaluating longitudinal fragmentomics model prediction and ctDNA status
TABLE 2 from Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis
Authors: Karim Mohammad A. , Singal Amit G. , Kum Hye Chung , Lee Yi-Te , Park Sulki , Rich Nicole E. , Noureddin Mazen , Yang Ju Dong
Published: May 2023

Factor associated with OS for patients with HCC
TABLE 1 from Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis
Authors: Karim Mohammad A. , Singal Amit G. , Kum Hye Chung , Lee Yi-Te , Park Sulki , Rich Nicole E. , Noureddin Mazen , Yang Ju Dong
Published: May 2023

Demographic and clinical characteristics of patients with HCC
FIGURE 2 from Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis
Authors: Karim Mohammad A. , Singal Amit G. , Kum Hye Chung , Lee Yi-Te , Park Sulki , Rich Nicole E. , Noureddin Mazen , Yang Ju Dong
Published: May 2023

OS estimates by Imaging group. Comparison of OS between patients with HCC receiving different types of imaging without adjustment for lead-time bias (A) and after adjustment for lead-time bias with mean sojourn time of 6 months (B). Median OS was 20.5 months (95% CI: 19–22 months), 15 months (95% CI: 13–17 months), and 10 months (95% CI: 9–11 months) for CT/MRI, US, and no imaging, respectively without adjustment for lead-time bias. Median OS was 16.7 months (95% CI: 15.8–18.6 months) and 12 months (95% CI: 10.7–14.1 months) for CT/MRI and US, respectively, with adjustment for lead-time bias. Lead-time adjustment would not affect median OS of no imaging group. CT, computed tomography; HCC, hepatocellular carcinoma; MRI, magnetic resonance imaging; US, ultrasound.
Data from Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis
Authors: Karim Mohammad A. , Singal Amit G. , Kum Hye Chung , Lee Yi-Te , Park Sulki , Rich Nicole E. , Noureddin Mazen , Yang Ju Dong
Published: May 2023

Ultrasound-based surveillance has suboptimal sensitivity for early hepatocellular carcinoma (HCC) detection, generating interest in alternative surveillance modalities. We aim to investigate the association between prediagnostic CT or MRI and overall survival in a contemporary cohort of patients with HCC. Using the Surveillance Epidemiology and End Results (SEER)-Medicare database, we analyzed Medicare beneficiaries diagnosed with HCC between 2011 and 2015. Proportion of time covered (PTC) was defined as the proportion of the 36-month period prior to HCC diagnosis in which patients had received abdominal imaging (ultrasound, CT, MRI). Cox proportional hazards regression was used to investigate the association between PTC and overall survival. Among 5,098 patients with HCC, 3,293 (65%) patients had abdominal imaging prior to HCC diagnosis, of whom 67% had CT/MRI. Median PTC by any abdominal imaging was 5.6% [interquartile range (IQR): 0%–36%], with few patients having PTC >50%. Compared with no abdominal images, ultrasound [adjusted HR (aHR): 0.87, 95% confidence interval (CI): 0.79–0.95] and CT/MRI group (aHR: 0.68, 95% CI: 0.63–0.74) were associated with improved survival. Lead-time adjusted analysis showed improved survival continued to be observed with CT/MRI (aHR: 0.80, 95% CI: 0.74–0.87) but not ultrasound (aHR: 1.00, 95% CI: 0.91–1.10). Increased PTC was associated with improved survival, with a larger effect size observed with CT/MRI (aHR per 10%: 0.93, 95% CI: 0.91–0.95) than ultrasound (aHR per 10%: 0.96, 95% CI: 0.95–0.98). In conclusion, PTC by abdominal images was associated with improved survival in patients with HCC, with potential greater benefit using CT/MRI. Regular utilization of CT/MRI before cancer diagnosis may have potential survival benefit compared to ultrasound in patients with HCC.
Significance:
Our population-based study using SEER-Medicare database demonstrated that proportion of time covered by abdominal imaging was associated with improved survival in patients with HCC, with potential greater benefit using CT/MRI. The results suggest that CT/MRI surveillance may have potential survival benefit compared with ultrasound surveillance in high-risk patients for HCC. A larger prospective study should be conducted for external validation.
Data from Targeting CHAF1B enhances Interferon activity against Myeloproliferative Neoplasm cells
Authors: Saleiro Diana , Kosciuczuk Ewa M , Fischietti Mariafausta , Perez Ricardo E , Yang G. Sohae , Eckerdt Frank , Beauchamp Elspeth M. , Hou Ye , Wang Qixuan , Weinberg Rona Singer , Fish Eleanor N. , Yue Feng , Hoffman Ronald , Platanias Leonidas C.
Published: May 2023

Abstract
Interferons (IFNs) are cytokines with potent antineoplastic and antiviral properties. IFNα has significant clinical activity in the treatment of myeloproliferative neoplasms (MPN), but the precise mechanisms by which it acts are not well understood. Here, we demonstrate that chromatin assembly factor 1 subunit B (CHAF1B), an Unc-51-like kinase 1 (ULK1)-interactive protein in the nuclear compartment of malignant cells, is overexpressed in MPN patients. Remarkably, targeted silencing of CHAF1B enhances transcription of IFNα-stimulated genes and promotes IFNα-dependent antineoplastic responses in primary MPN progenitor cells. Taken together, our findings indicate that CHAF1B is a promising newly identified therapeutic target in MPNs and that CHAF1B inhibition in combination with IFNα therapy might offer a novel strategy for treating MPN patients.
A América do Sul no tempo do Bicentenário da Independência do Brasil: revitalização da Unasul e reconstrução da integração regional
Authors: Barros Pedro Silva
Published: May 2023

Este trabalho tem por objetivo a) discutir a integração regional em perspectiva histórica e a América do Sul no marco do Bicentenário da Independência do Brasil, b) apresentar e analisar os desdobramentos econômicos e políticos da prioridade que o Brasil deu para a América do Sul a partir de 2000, c) comparar as diferentes institucionalidades da governança regional (Unasul, Prosul, Grupo de Lima) e d) delimitar os pontos centrais da revitalização da Unasul e da agenda de integração regional.
Transcatheter Aortic Valve Replacement and Impact of Subclinical Leaflet Thrombosis in Low-Risk Patients: LRT Trial 4-Year Outcomes
Authors: Waksman Ron , Bhogal Sukhdeep , Gordon Paul , Ehsan Afshin , Wilson Sean R. , Levitt Robert , Parikh Puja , Bilfinger Thomas , Hanna Nicholas , Buchbinder Maurice , Asch Federico M. , Kim Francis Y. , Weissman Gaby , Ben-Dor Itsik , Shults Christian C. , Ali Syed , Sutton Joseph A. , Shea Corey , Zhang Cheng , Garcia-Garcia Hector M. , Satler Lowell F. , Rogers Toby
Published: May 2023

Background:

The LRT trial (Low-Risk Transcatheter Aortic Valve Replacement [TAVR]) demonstrated the safety and feasibility of TAVR in low-risk patients, with excellent 1- and 2-year outcomes. The objective of the current study is to provide the overall clinical outcomes and the impact of 30-day hypoattenuated leaflet thickening (HALT) on structural valve deterioration at 4 years.

Methods:

The prospective, multicenter LRT trial was the first Food and Drug Administration-approved investigational device exemption study to evaluate feasibility and safety of TAVR in low-risk patients with symptomatic severe tricuspid aortic stenosis. Clinical outcomes and valve hemodynamics were documented annually through 4 years.

Results:

A total of 200 patients were enrolled, and follow-up was available on 177 patients at 4 years. The rates of all-cause mortality and cardiovascular death were 11.9% and 3.3%, respectively. The stroke rate rose from 0.5% at 30 days to 7.5% at 4 years, and permanent pacemaker implantation rose from 6.5% at 30 days to 11.7% at 4 years. Endocarditis was detected in 2.5% of the cohort, with no new cases reported between 2 and 4 years. Transcatheter heart valve hemodynamics remained excellent post-procedure and were maintained (mean gradient 12.56±5.54 mm Hg and aortic valve area 1.69±0.52 cm
2
) at 4 years. At 30 days, HALT was observed in 14% of subjects who received a balloon-expandable transcatheter heart valve. There was no difference in valve hemodynamics between patients with and without HALT (mean gradient 14.94±5.01 mm Hg versus 12.3±5.57 mm Hg;
P
=0.23) at 4 years. The overall rate of structural valve deterioration was 5.8%, and there was no impact of HALT on valve hemodynamics, endocarditis, or stroke at 4 years.

Conclusions:

TAVR in low-risk patients with symptomatic severe tricuspid aortic stenosis was found to be safe and durable at 4 years. Structural valve deterioration rates were low irrespective of the type of valve, and the presence of HALT at 30 days did not affect structural valve deterioration, transcatheter valve hemodynamics, and stroke rate at 4 years.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02628899.
Precarity and Possibility
Authors: Atwood Blake
Published: May 2023

At first glance, Iran and Lebanon may appear to have very little in common when it comes to state intervention in the media economy. The Iranian government oversees nearly every aspect of media production, distribution, and exhibition, while the Lebanese state exercises relatively little oversight of media and offers no financial or infrastructural support to the country’s robust creative industries. Given the divergent approaches to regulating media in Iran and Lebanon, we might expect each to yield vastly different media labor conditions. Yet in this article, I argue the opposite. I demonstrate how the two extremes foster informal labor practices that are remarkably similar. By bringing together these two unlikely case studies, I advocate for informality as a constitutive feature of Middle Eastern media. Such a claim expands the growing body of scholarship on media labor by accounting for the triangulation of informality, state regulation, and worker subjectivity.
Collecting contemporary art in Rotterdam between 1870 and 1892: The international taste of Fop Smit Jr (1815-1892)
Authors: De Visser Evelien
Published: May 2023

The extensive international art collection of the now virtually forgotten Rotterdam collector Fop Smit Jr (1815-1892) included as many as 240 contemporary European genre paintings and several works by renowned artists of the Barbizon School. After Smit’s death, his collection was divided among his family. The recent discovery of a two-part album containing photographs of the works of art he owned made it possible to reconstruct his collection for the first time.

Based on extensive provenance and archival research, his collection is analysed and placed in the context of collecting contemporary art in Rotterdam and the Netherlands in the 1870s and 1890s. This reveals that Smit’s collection differed from the prevailing Dutch taste at that time. It was distinctly internationally oriented as well as larger than most other Dutch collections. Moreover, Smit did not combine paintings with works on paper or old master art, as was customary. Other Rotterdam collectors exhibit an international orientation similar to Smit’s. This is partly because, like him, they were advised by Rotterdam art dealers such as Jos de Kuyper, Jan van Mastenbroek and Willem Hendrik Köhler.

In his collecting pursuits, Fop Smit was guided by his mercantile ethos. He was a shipowner and came from a successful family of shipbuilders. In addition, he owned stocks and bonds at home and abroad worth several million guilders. His collection and motives for collecting dovetailed with the development of the growing international art market, in which Smit can be considered as one of the new, upper-middle-class collectors in a position to compete with other industrialists and for whom money was no object.
Living in the darkness: a new cave cricket species of the genus Endecous Saussure (Orthoptera, Grylloidea, Phalangopsidae) from Serra da Bodoquena in Mato Grosso do Sul state, Brazil
Authors: CAMPOS LUCAS DENADAI DE , BOLFARINI MÁRCIO PEREZ , SUEMITSU MÔNICA MIDORI , BORGHEZAN LÍVIA MEDEIROS CORDEIRO , SOUZA-DIAS PEDRO G. B.
Published: May 2023

We describe a new species of the genus Endecous Saussure (1878), recorded at the Dente de Cão and Urubu Rei caves, which are located in the Bodoquena municipality, state of Mato Grosso do Sul, Brazil. Species of Endecous are the most common of crickets in Brazilian hypogean environments. Endecous comprises 24 species described and is widely distributed throughout South America, occurring also in Argentina, Bolivia and Uruguay. We also present a brief discussion about the presence of the genus in subterranean environments and a distribution map of Endecous troglobitic species through the regions of the Brazilian karst.
A new species of Glabellula Bezzi, 1902 (Diptera: Mythicomyiidae: Glabellulinae) from Colombia, and an updated key to South American species
Authors: RAMOS-PASTRANA YARDANY , CÓRDOBA-SUAREZ ERIC , EVENHUIS NEAL. L
Published: May 2023

Glabellula Bezzi, 1902 has a cosmopolitan distribution and is a poorly studied group in the Neotropical Region, and completely unknown in Colombia. One new species of Glabellula is described from Colombia, namely Glabellula antioquensis sp. nov. (type-locality: Buriticá, La Angelina). Illustrations and a dichotomous key to the South American species are presented.
A new species of the genus Formosaspis Takahashi, 1932 (Hemiptera: Coccomorpha: Diaspididae) from China
Authors: JIAN QIAN , TIAN FENG , XING JICHUN
Published: May 2023

A new species of armoured scale insect, Formosaspis fanjingensis sp. n. (Hemiptera: Coccomorpha: Diaspididae), is described; it was found on Chimonobambusa spp. (Poaceae; Bambusoideae) in Guizhou Province, China. Habitat photographs and taxonomic illustrations are provided. The type specimens are deposited at the Institute of Entomology, Guizhou University, Guiyang, China (GUGC). An identification key based on the morphology of adult females is provided to separate all the species in the genus.
First report of brittle stars (Echinodermata: Ophiuroidea) from a seamount in the eastern Arabian Sea
Authors: U. ABDUL JALEEL K. , PARAMESWARAN USHA V. , BIJU ANAGHA , S. PARTHASARATHI , ABDULAZIZ ANAS
Published: May 2023

This paper reports two species—Ophiozonella molesta (Koehler, 1904) and Ophiothamnus venustus Matsumoto, 1915, from a seamount in the Eastern Arabian Sea. This forms the first ever report of Ophiothamnus venustus from the Indian Ocean, and the first verified report of Ophiozonella molesta from Indian waters. This is the first ever work to document benthic invertebrates from seamounts in the Arabian Sea.
Kelvin–Helmholtz Instability “Tube” and “Knot” Dynamics. Part I: Expanding Observational Evidence of Occurrence and Environmental Influences
Authors: Fritts David C. , Baumgarten Gerd , Pautet P.-Dominique , Hecht James H. , Williams Bifford P. , Kaifler Natalie , Kaifler Bernd , Kjellstrand C. Bjorn , Wang Ling , Taylor Michael J. , Miller Amber D.
Published: May 2023

Multiple recent observations in the mesosphere have revealed large-scale Kelvin–Helmholtz instabilities (KHI) exhibiting diverse spatial features and temporal evolutions. The first event reported by Hecht et al. exhibited multiple features resembling those seen to arise in early laboratory shear-flow studies described as “tube” and “knot” (T&K) dynamics by Thorpe. The potential importance of T&K dynamics in the atmosphere, and in the oceans and other stratified and sheared fluids, is due to their accelerated turbulence transitions and elevated energy dissipation rates relative to KHI turbulence transitions occurring in their absence. Motivated by these studies, we survey recent observational evidence of multiscale Kelvin–Helmholtz instabilities throughout the atmosphere, many features of which closely resemble T&K dynamics observed in the laboratory and idealized initial modeling. These efforts will guide further modeling assessing the potential importance of these T&K dynamics in turbulence generation, energy dissipation, and mixing throughout the atmosphere and other fluids. We expect these dynamics to have implications for parameterizing mixing and transport in stratified shear flows in the atmosphere and oceans that have not been considered to date. Companion papers describe results of a multiscale gravity wave direct numerical simulation (DNS) that serendipitously exhibits a number of KHI T&K events and an idealized multiscale DNS of KHI T&K dynamics without gravity wave influences.

Significance Statement

Kelvin–Helmholtz instabilities (KHI) occur throughout the atmosphere and induce turbulence and mixing that need to be represented in weather prediction and other models of the atmosphere and oceans. This paper documents recent atmospheric evidence for widespread, more intense, features of KHI dynamics that arise where KH billows are initially discontinuous, misaligned, or varying along their axes. These features initiate strong local vortex interactions described as “tubes” and “knots” in early laboratory experiments, suggested by, but not recognized in, earlier atmospheric and oceanic profiling, and only recently confirmed in newer, high-resolution atmospheric imaging and idealized modeling to date.