bluuebunny/crossref_metadata_2025 huggingface dataset:
Metode Analytical Hierarchy Process (AHP) Dalam Penilaian Kompetensi Soft Skill Pegawai Kantor Balai Desa Ambalutu
Authors: Safitri Dewi , Anggraeni Dewi , Suparmadi Suparmadi
Published: February 2021

Abstract: Employees are a highly needed human resource. In order to achieve the desired goals, the agency conducts performance assessments on the soft skill competencies of its employees. Employee performance appraise based on communication, honesty, cooperation, and personal skills. Analytical hierarchy proces (AHP) method, pairwise comparison assesment to get priority value. In this srudy, the result show the rasio of 0.07 which means that the assesment is consistent because it is less than 0.1, so that the percetage of the calculation is 40%,honesty 34%, cooperation 17%, and personal 10%. The result of this study indicate that the AHP method can be used  a method for assesing the soft skills competence of employeesof the ambalutu village office. Keywords: Analytical Hierarchy Process (AHP), Soft Skill, Village hall Office  Abstrak: Pegawai merupakan sumber daya manusia yang sangat dibutuhkan. Demi mencapai tujuan yang diinginkan maka instansi melakukan penilaian kinerja terhadap kompetensi soft skill pegawainya. Penilaian kinerja pegawai berdasarkan kemampuan Komunikasi, Kejujuran, kerja Sama, dan Personal. Metode Analytical Hierarchy Process (AHP), penilaian perbandingan berpasangan untuk mendapatkan nilai prioritas. Pada penelitian ini menunjukkan hasil rasio 0.07 yang berarti penilaian yang dilakukan tersebut konsisten karena kurang dari 0.1, sehingga memperoleh persentase perhitungan dengan nilai Komunikasi 40%, Kejujuran 34%, Kerjasama 17%, dan personal 10%. Hasil penelitian ini menunjukkan bahwa metode AHP dapat digunakan sebagai metode untuk penilaian kompetensi soft skill pegawai Kantor Balai Desa Ambalutu. Kata kunci: Analytical Hierarchy Process (AHP), Soft Skills, Kantor Balai Desa
Modified Caldwell-Luc Technique to retrieval of tooth fragment displaced into the maxillary sinus: A case report
Authors: Santos José Wittor de Macêdo , Oliveira Emily Ricelly da Silva , Chaves Neto Humberto Pereira , Ramos Fernanda Soares , Fonseca Neto Braz da , Gomes Edynelson da Silva , Germano Adriano Rocha
Published: February 2021

During the surgical removal of maxillary molars, tooth or fragment displacement into the maxillary sinus may occur. The presence of foreign bodies inside these cavities leads to complications such as mucoceles, cellulitis, oroantral fistulae and maxillary sinusitis, to prevent the arise and worsening of complications, these events must be addressed in an early stage. This article aims to report the removal of a tooth root from the maxillary sinus, through the modified Caldwell-Luc (CLM) approach and describe the current indications for the Caldwell Luc technique. It reports an upper third molar surgery in which a patient had the distal root of the left superior third molar displaced into the maxillary sinus, later showing signs of sinus opacification and loss of patency of the maxillary ostium obstructed by the root. After antibiotic treatment, the root was recovered through the CLM technique by local anesthesia, without complications. Foreign bodies in the maxillary sinuses must be urgently addressed, avoiding the development of infectious conditions, the CLM approach is the choice approach to manage these complications by a simple and safe way.
Síndrome dos ovários policísticos: aspectos clínicos e impactos na saúde da mulher
Authors: Cavalcante Igor dos Santos , Mendes Isabella Pires Gomes , Silva Martha Laura Leão dos Santos , Barbosa Giovanna Stefanne Lópes , Hasegawa Luciana Eda Maximiano , Veiga Ana Vitória Meireles , Ferraz Isabella Cabral , Gomes Francisco Enson Souza , Santos Lúcia Maria de Sousa Aguiar dos
Published: February 2021

Objetivo: Descrever os aspectos clínicos da Síndrome dos Ovários Policísticos (SOP) e seu impacto na saúde da mulher. Metodologia: Revisão integrativa da literatura utilizando as bases de dados Scientific Eletronic Library Online (SciELO), PUBMED e Literatura Latino-Americana e do Caribe (LILACS). Resultados: A análise do quadro clínico da SOP foi dividida em cinco tópicos: influência da Resistência Insulínica (RI); relação com a obesidade; hiperandrogenismo e hirsutismo; Síndrome Metabólica (SM) e risco cardiovascular; e interferência na vida sexual. Nesse sentido, o estado hiperglicêmico gerado pela RI determinou o desenvolvimento de diabetes e acantose nigricante, enquanto que obesidade foi observada tanto como consequência da SOP, quanto como um fator agravante dos sintomas dessa síndrome. Ademais, a presença de SM foi influenciada pelo Índice de Massa Corpórea (IMC) e idade. Quanto à sexualidade, os estudos notaram a ocorrência de disfunção sexual, decorrente de alterações físicas e desordem hormonal, e de infertilidade, devido à não ovulação. Conclusão: Conclui-se que a SOP gera uma gama bastante heterogênea de sintomas, que se manifestam em mais de uma fase da vida da mulher e por isso é necessária uma abordagem holística à paciente. Além disso, os hábitos de vida saudáveis, como dieta balanceada e exercícios físicos, influenciam positivamente na melhora dos sintomas.
O papel do enfermeiro frente a casos de morte encefálica e doação de órgãos e tecidos
Authors: Furtado Loyane Barbosa dos Santos , Moraes Filho Iel  Marciano de , Sousa Thais Vilela de , Roure Jéssica Guimarães Rodrigues de , Lima Thaís Pereira , Arantes Aline  Aparecida , Silva Reginaldo Martins da , Pereira Mayara Cândida , Carvalho Filha Francidalma Soares Sousa
Published: February 2021

Objetivo: Descrever o desempenho do enfermeiro no processo de morte encefálica e na doação de órgãos e tecidos. Método: Trata-se de um estudo de revisão narrativa da literatura com abordagem qualitativa exploratória voltada para atuação do enfermeiro em casos de morte encefálica e doação de órgãos. Resultados: Foram selecionados 14 artigos de acordo com o tema, após a interpretação foram divididos em duas categorias: a conduta da enfermagem frente ao possível doador com morte encefálica e diante a família dos pacientes com morte encefálica. Conclusão: O enfermeiro se apresenta como um otimizador de todo o processo de doação de órgãos e tecidos, ademais de ter um papel importante na busca ativa e na manutenção de pacientes com morte encefálica, além de se articular com os familiares na tentativa de obter uma decisão favorável à doação. A entrevista de enfermagem mostrou-se como um instrumento preditor que, se direcionado de maneira efetiva e humanizada, é capaz de evitar uma recusa familiar na tomada de decisão frente à doação.
Influência de agentes precipitantes no desempenho de catalisadores de ferro na desidrogenação do etilbenzeno
Authors: Varela Maria do Carmo Rangel , Barral Bruna Caroline de Oliveira , Lima Simone Pereira de , Lima Sirlene Barbosa
Published: February 2021

A desidrogenação catalítica do etilbenzeno, com vapor de água, é a tecnologia dominante para a produção industrial de estireno, que é uma matéria-prima extensivamente usada na manufatura de plásticos. O catalisador comercial é constituído de óxido de ferro dopado com potássio e cromo e apresenta baixa área superficial específica, além de ser susceptível à desativação. Visando à obter catalisadores mais eficientes que aqueles disponíveis comercialmente estudou-se, neste trabalho, o efeito do agente precipitante sobre o desempenho de catalisadores de ferro, baseados em hematita. As amostras foram preparadas pelo método sol-gel, usando hidróxido de amônio, hidróxido de potássio e carbonato de potássio como agentes precipitantes e avaliadas na desidrogenação do etilbenzeno a 480, 530, 580 e 630 oC. Observou-se que o agente precipitante mais adequado foi o carbonato de potássio, que produziu o catalisador mais ativo, com área superficial específica e resistência à redução mais elevadas. Na temperatura dos processos industriais (530 oC), esse catalisador foi quatro vezes mais ativo que uma amostra comercial.
Efetividade do tratamento ortodôntico interceptativo com aparelho removível em crianças com mordida cruzada e mordida aberta na fase de dentadura mista
Authors: Souza Ricardo Alves de , Reis Victoria Sousa Carneiro , Silva Dábila Ferreira da , Almeida Aislan Pereira de , Freitas Lívia Maria Andrade de , Pithon Matheus Melo
Published: February 2021

A interceptação de maloclusões em estágios iniciais contribui para um crescimento equilibrado das bases ósseas. Dentre as maloclusões que devem ser corrigidas antecipadamente, destacam-se as mordidas cruzadas e mordidas abertas, nessa ordem de prioridade. Uma gama de possibilidades terapêuticas existe descritas na literatura, entre essas, o uso de aparelho removível com expansor e grade lingual. Entretanto, poucas evidências validam essa forma de tratamento, baseado nesse pressuposto o objetivo do presente estudo foi avaliar a efetividade do aparelho removível com expansor e grade lingual para correção da mordida cruzada posterior associado a mordida aberta anterior. Analisou-se as documentações ortodônticas de 148 crianças na faixa etária de 5 a 12 anos de idade que receberam tratamento entre os anos de 2009 e 2018. A efetividade ou não do tratamento foi verificada ao analisar fotografias e modelos de estudo em duas etapas de tratamento: inicial e final. Após realização de testes Shapiro-Wilk, as frequências foram comparadas pelo teste qui-quadrado e as variáveis calculadas a partir do teste Kruskal-Wallis. Foi constatado que 74% dos casos de mordida cruzada e 91,7 % dos casos de mordida aberta foram corrigidos. Dessa forma pode-se concluir que a correção da mordida aberta e mordida cruzada foi conseguida com o uso desses dispositivos.
Caracterização físico-química, microbiológica e da atividade antioxidante de farinhas de casca e amêndoa de manga (Mangifera indica) e sua aplicação em brownie
Authors: Ramos Sabrina Alves , Silva Mauro Ramalho , Jacobino Aureane Rodrigues , Damasceno Iasmin Alves Nani , Rodrigues Sheyla Moreira , Carlos Gracielle Alves , Netto Rocha Viviane , Augusti Rodinei , Melo Júlio Onésio Ferreira , Capobiango Michely
Published: February 2021

O objetivo desse estudo foi desenvolver farinhas com amêndoa (FAM) e casca de manga (FCM), cultivar Tommy Atkins, caracterizar suas propriedades físico-químicas e microbiológicas, determinar atividade antioxidante e desenvolver brownie utilizando as farinhas. Ainda, identificar os compostos voláteis presentes nas farinhas, nos brownies e no cacau. Foi elaborado brownie de chocolate tradicional e com a substituição de 70% da farinha de trigo pela mistura das farinhas obtidas. As FAM e FCM apresentaram-se como fontes de nutrientes, com destaque ao alto teor de fibras alimentares (média de 37%), e seguras do ponto de vista microbiológico. Além disto, as FAM e FCM são ricas em compostos fenólicos (4.495 e 3.340 mg AGE/100 g) e possuem elevada atividade antioxidante. O brownie elaborado com a mistura de farinhas apresentou perfil nutricional com maior valor de fibras, lipídeos e calorias que o tradicional. Considerando todas as amostras analisadas foram identificados 32 compostos voláteis. Nas farinhas foram encontrados compostos das classes de terpenos, aldeídos e éster. Já nos brownies, além das classes citadas, no tradicional foram identificados álcoois, pirazinas e ácidos graxos. No cacau foram encontrados hidrocarbonetos, pirazinas, terpenos, aldeídos, álcoois e ésteres. Dessa forma, pode-se afirmar que a utilização de coprodutos da manga é segura do ponto de vista microbiológico, contribui para o enriquecimento nutricional e funcional de preparações, assim como para a redução dos resíduos descartados no ambiente.
Psicose induzida por drogas recreativas: uma revisão de literatura
Authors: Medeiros Daniel Nobrega , Ribeiro Juliana Fernandes de Souza , Trajano Larissa Alexsandra da Silva Neto
Published: February 2021

Psicose é um termo amplo que caracteriza uma série de distúrbios que têm em comum a produção dos chamados sintomas psicóticos, principalmente delírios e alucinações. Os transtornos psicóticos podem ser divididos em primários e secundários, incluindo-se nesta última categoria os transtornos psicóticos induzidos por substâncias, dentre as quais se destacam as drogas recreativas. O objetivo desta revisão foi analisar as principais características fisiopatológicas, sintomáticas, diagnósticas e terapêuticas dos transtornos psicóticos relacionados ao uso de drogas recreativas. Foi realizada uma busca por trabalhos prévios nas plataformas SciELO, Lilacs e PubMed e um total de 27 artigos científicos foram incluídos após a aplicação de critérios de inclusão e exclusão. Através dos estudos analisados foi observado que as drogas mais frequentemente associadas com transtornos psicóticos foram cannabis, anfetaminas, o álcool e a cocaína, sendo que os delírios, especialmente persecutórios, e as alucinações auditivas foram os principais sintomas relatados. Embora a fisiopatologia destes distúrbios não esteja completamente esclarecida, há evidências de que o uso de drogas ilícitas sejam um fator de risco para o desenvolvimento de eventos psicóticos, desta forma, o conhecimento dos fatores envolvidos nessa relação é importante na prática clínica. Em conclusão, é importante que os profissionais de saúde saibam que o uso de drogas recreativas pode levar ao desenvolvimento de psicose e que saibam avaliar a melhor forma de abordar esses pacientes para que possam oferecer o melhor suporte possível.
Plant growth regulators in the germination of Diospyros hispida A. DC. (EBENACEAE) seeds
Authors: Ramalho Aline Bueno , Braga Lúcia Filgueiras
Published: February 2021

Plant growth regulators in the germination of Diospyros hispida A. DC. (Ebenaceae) Seed. Diospyros hispida species is a native fruit that has long germination period, hindering seedling production. The aim of this work was to evaluate the germination of Diospyros hispida seeds under the effect of gibberellic acid and biostimulant applications. Four replicates of 25 seeds per treatment were used. Treatments were: T1 - distilled water, T2, T3 and T4 - GA3 solutions at 100, 150 and 200 mg L-1, respectively, T5 - Immersion for 24 hours in distilled water with aeration, T6, T7 and T8 - Immersion for 24 hours in aerated GA3 solutions at 100, 150 and 200 mg L-1, respectively, T9, T10 and T11 - biostimulant application (containing auxin, gibberellin and cytokinin) at 3, 5 and 7 ml kg-1 of seeds. Germination rate, mean germination time, germination speed index, synchronization index, relative germination frequency, normal seedlings, root length, shoot length and seedling dry mass were evaluated. The effect of gibberellic acid and biostimulant containing auxin, gibberellin and cytokinin negatively influenced Diospyros hispida germination under the conditions of this study.
Oral disorders in animals seen in the Dentistry sector of the University of Franca and prevention in the control of local and systemic impairments
Authors: Dias Fernanda Gosuen Gonçalves , Oliveira Alex Roberto de , Dias Luis Gustavo Gosuen Gonçalves , Pereira Lucas de Freitas , Derruci Marina Queiroz , Costa James Cintra
Published: February 2021

Diversas afecções orais podem acometer a espécie canina e felina, causando comprometimentos locais e sistêmicos. Assim, o objetivo do presente trabalho foi realizar estudo retrospectivo de 385 casos atendidos no setor cirúrgico de Odontologia de Pequenos Animais da Universidade de Franca, enfatizando os de fístulas infraorbitárias, fraturas dentárias e ósseas e neoplasias e, ademais, relacioná-los com a resenha dos pacientes (sexo, espécie, idade e raça) e tipo de alimentação. Os resultados foram expressos em percentuais. Das 385 fichas odontológicas, 30 pacientes foram diagnosticados com fístulas infraorbitárias (7,8%), 25 com fraturas dentárias (6,5%), 26 com fraturas ósseas (6,8%) e 28 com neoplasias (7,3%). Conforme descrito na literatura científica, não houve diferença significativa quanto ao gênero dos acometidos por todas as afecções orais. A espécie canina foi a mais afetada e a maioria dos pacientes era adultos a idosos. Os sem raça definida e os Poodles foram os mais acometidos. Quanto ao tipo de alimentação fornecida, a maioria era ração comercial; em contrapartida, grande parte oferecia ração comercial acrescida de comida caseira, o que pode predispor e agravar algumas enfermidades orais. Perante a metodologia preconizada e os dados obtidos, pode-se inferir que as fístulas infraorbitárias, fraturas dentárias, fraturas ósseas e neoplasias são comumente diagnosticadas em animais de companhia, principalmente em cães idosos e pequenos, podendo gerar danos locais e sistêmicos. A alimentação errônea pode predispor enfermidades orais; assim a divulgação aos tutores quanto aos cuidados odontológicos pode melhorar a qualidade de vida e sobrevida dos cães e gatos.
A Matriz SWOT e suas Subdimensões: Uma Proposta de Inovação Conceitual
Authors: Costa Júnior João Florêncio da , Bezerra Diogo de Menezes Cortês , Cabral Eric Lucas dos Santos , Moreno Rosângela Carmelita Pessoa , Pires Ahanna Kiaara Souza
Published: February 2021

O presente trabalho objetiva propor uma releitura da análise SWOT, apresentando um modelo adequado às demandas e transformações das organizações modernas, focando em uma definição mais robusta e específica das categorias da matriz SWOT – forças fraquezas, oportunidades e ameaças. A pesquisa foi dividida em duas etapas: i) pesquisa bibliográfica e documental; e ii) pesquisa-ação com observação participante. Durante o período de 2014 a 2016 em uma empresa Britânica no ramo de Business Intelligence, pôde-se avaliar o progresso do uso e da adaptação da análise SWOT às demandas de competitividade. Baseados nas evidências documentais e empíricas, os autores propuseram uma releitura da MATRIZ SWOT em que cada uma das dimensões originais é subdividida em cinco subcategorias, oferecendo assim, uma ferramenta para dar suporte a análises mais detalhadas e robustas. As forças e fraquezas são divididas nas seguintes categorias: i) sintomáticas; ii) adormecidas; iii) constantes; iv) circunstanciais; e iv) tangíveis. As oportunidades são divididas nas seguintes categorias: i) exploradas; ii) passageiras; iii) desperdiçadas; iv) inacessíveis; e v) disfarçadas. Por fim, as ameaças apresentam as seguintes subcategorias: i) constantes; ii) passageiras; iii) adormecidas; iv) provocadas; e v) disfarçadas. Este trabalho contribui com a literatura e a prática da gestão estratégica ao oferecer uma alternativa para endereçar as dificuldades de precisão na definição das categorias da Matriz SWOT, criando subcategorias até então não levantadas na literatura para que se possa mais precisamente abarcar forças e fraquezas e melhor avaliar oportunidades e ameaças, validando assim, a continuidade do uso desta ferramenta.
Propriedades físicas do solo em níveis variáveis de compactação do solo
Authors: Bareta Junior Eloi , Silva André Augusto Pazinato da , Sens Talyta Mytsuy Zanardini Galeski , Colecha Keli , Rampim Leandro , Pott Cristiano Andre
Published: February 2021

Devido o intenso trafego de máquinas e equipamentos agrícolas para o manejo das culturas, a compactação do solo vem causando preocupação por parte de agricultores. O trabalho teve como objetivo avaliar a qualidade física de um Latossolo Bruno com níveis distintos de compactação tratorizada, na região de Guarapuava, Paraná, Brasil. O delineamento experimental utilizado foi o de blocos ao acaso, com seis repetições. Os tratamentos foram quatro níveis de compactação produzidos por tráfico de trator, representados por: testemunha (sem compactação), duas, cinco e vinte passadas. Verificou-se que a compactação do solo com tráfego de trator superiores a duas passadas, proporcionaram aumento das variáveis grau de compactação, argila dispersa em água e grau de dispersão, assim como redução do grau de floculação das argilas. Assim, ressalta a importância de considerar nas operações agrícolas que mesmo níveis baixos de tráfego de trator são capazes de reduzir a qualidade física do solo.
BATMAN RIBONE (Batik Malangan Triple Bottomline) Implementation Triple Bottomline for Small Medium Enterprise (SME) in Malang Regency
Authors: Amerieska Siti , Kartiko Galuh , Nugrahani Novi , Wijayanti Rika , Nikmah Farika
Published: February 2021

Batik Malangan craftsmen SMEs need a presence in the world of business development. The main problems faced by batik SMEs are 1) lack of good management which covers Planning, Organizing, Actuating and Controlling (POAC) as the focus of management implementation within the context of developing Batik Malangan products, 2) lack of entrepreneurial funds, 3) lack of Batik Malangan socialization (marketing), owing to the lack of web and social media presence 4) Not having financial reports, especially reports within the framework of Triple Bottom Lines (Sustainability Report). The possible solutions are in the form of assistance in the preparation of management procedure systems and the establishment of a marketplace specializing in batik products of Malang. The methods used are in the form of mentoring and training on the use of the procedure system, and the application of a web-based marketplace. The results of this community service, with the existence of Batman Ribone standard operating procedure (SOP), which contains a production planning SOP, SME owners have become increasingly aware of the importance of production planning. The existence of this web-based marketplace increased the number of customers by up to 20% and has made it easier for them to access Batik Malangan products.
PEMANFAATAN DATA SUMBER DAYA MANUSIA PERGURUAN TINGGI DENGAN DATA MART UNTUK MELIHAT PERFORMA DAN PORTOFOLIO DOSEN
Authors: Prasetiya Hendro Poerbo , Susilowati Meme
Published: February 2021

Sebuah perguruan tinggi perlu memantau dan pengukuran kinerja terus-menerus untuk memastikanapakah kinerja dan portofolio dosen sesuai dengan parameter yang telah ditentukan atau tidak. Salahsatu cara untuk mengatasi hal ini adalah dengan memanfaatkan Informasi visualisasi denganmenggunakan Data Mart. Dengan membangun Data Mart, data kinerja dan portofolio dosen akandikelompokkan sesuai kebutuhan yang mengandung informasi penting sehingga mudah dibaca dandipahami, sehingga pimpinan perguruan tinggi dapat segera melihat dan mengambil keputusan yangdibutuhkan dengan cepat dan tepat. .
TECHNIQUE FOR ORDER PREFERENCE BY SIMILARITY TO IDEAL SOLUTION UNTUK MEMILIH JURUSAN BAGI SISWA SMA BERDASARKAN KECERDASAN GANDA
Authors: Ahsan Moh. , Permatasari Devi , Marsitin Retno
Published: February 2021

Setiap manusia mempunyai lebih dari satu kecerdasan ganda, seperti logika-matematika, visual-spasial, interpersonal, intrapersonal, linguistik, musikal, naturalis, dan kinestestis (Howard Gardner dari Harvard University). Banyak cara, untuk melihat kecerdasan seseorang diantaranya melalui angka, musik, gambar, kata-kata, kegiatan fisik atau sosial-emosional. Banyak hasil riset mengenai kecerdasan siswa, mengharap kepada orang tua dan wali murid agar selalu memberikan banyak pengaraha, stimulasi dan pengalaman kepada siswa.Pendidikan menjadi point penting untuk orang tua dalam meningkatkan kecerdasan anaknya, dimana dalam lembaga pendidikan anak sebagai peserta didik atau siswa dapat diarahkan kepada bakat, minat dan potensi yang dimilikinya. Jika anak tidak tersentuh oleh dunia pendidikan maka potensi kecerdasan yang dimiliki seorang anak tidak akan berkembang dengan maksimal.Pemilihan jurusan sejak awal bisa mempermudah siswa dalam memilih bidang ilmu atau jurusan yang akan ditekuninya di akademik, sekolah tinggi atau di Universitas kelak yang tentunya akan mengarah kepada masa depan dan karirnya. Sejak diberlakukannya kurikulum 2013 dimana sistem peminatan sudah dimulai dan dilakukan dari kelas Sepuluh atau kelas satu. Hal ini tentunya membutuhkan peran guru Bimbingan Konseling (BK) untuk mengarahkan anak ke bakat, minat dan potensi akademiknya. Pilihan tersebut terdiri dari Ilmu Pengetahuan Alam (IPA), Ilmu Pengetahuan Sosial (IPS) , dan BAHASA (KEMEDIKBUD 2012).Technique for Order Preference by Similiarty to Ideal Solution (TOPSIS) adalah diantara salah satu metode yang didalam MADM (Multiple-Attribute Decesion Making) dan merupakan salah satu pemodelan decision support system (SPK) digunakan untuk pengambilan sebuah keputusan dalam menetapkan kriteria yang terbaik dari beberapa alternatif berdasarkan beberapa kriteria yang telah ditentukan sebelumnya.
SISTEM PEMESANAN RUMAH MAKAN XYZ BERBASIS DESKTOP
Authors: . Dafid , Wijaya Novan
Published: February 2021

Rumah makan XYZ yang berada di kota Palembang merupakan sebuah usaha penjualan makanan dan minuman dalam bentuk kuliner. Rumah makan XYZ sendiri masih menggunakan prosedur yang masih manual dalam kegiatan operasional, seperti dalam pemesanan makanan, minuman, maupun dalam proses pemesanan meja makan. Sistem yang kami kembangkan untuk rumah makan XYZ bertujuan untuk meminimalisir kesalahan yang akan terjadi pada saat proses pemesanan makanan, minuman, proses pembayaran, maupun pelaporan baik itu pelaporan yang dilakukan perhari ataupun perbulan. Adanya aplikasi ini diharapkan dapat mempermudah dalam melihat laporan seperti makanan dan minuman apa saja yang sering dipesan oleh para pengunjung. Sementara untuk metodologi yang digunakan dalam proses pembuatan aplikasi pemesanan makanan dan minuman ini menggunakan model itterative dimana setiap fase dari pengembangan sistem dilaksanakan secara berulang-ulang sampai mendapatkan hasil yang diinginkan.
“All-In-One” Genetic Tool Assessing Endometrial Receptivity for Personalized Screening of Female Sex Steroid Hormones
Authors: Deryabin Pavel , Domnina Alisa , Gorelova Inga , Rulev Maxim , Petrosyan Mariya , Nikolsky Nikolay , Borodkina Aleksandra
Published: February 2021

Endometrium is the uterine lining that undergoes hundreds of cycles of proliferation, differentiation, and desquamation throughout a woman's reproductive life. Recently, much attention is paid to the appropriate endometrial functioning, as decreased endometrial receptivity is stated to be one of the concerns heavily influencing successes of embryo implantation rates and the efficacy of in vitro fertilization (IVF) treatment. In order to acquire and maintain the desired endometrial receptivity during IVF cycles, luteal phase support by various progestagens or other hormonal combinations is generally recommended. However, today, the selection of the specific hormonal therapy during IVF seems to be empirical, mainly due to a lack of appropriate tools for personalized approach. Here, we designed the genetic tool for patient-specific optimization of hormonal supplementation schemes required for the maintenance of endometrial receptivity during luteal phase. We optimized and characterized in vitro endometrial stromal cell (ESC) decidualization model as the adequate physiological reflection of endometrial sensitivity to steroid hormones. Based on the whole transcriptome RNA sequencing and the corresponding bioinformatics, we proposed that activation of the decidual prolactin (PRL) promoter containing ancient transposons MER20 and MER39 may reflect functioning of the core decidual regulatory network. Furthermore, we cloned the sequence of decidual PRL promoter containing MER20 and part of MER39 into the expression vector to estimate the effectiveness of ESC decidual response and verified sensitivity of the designed system. We additionally confirmed specificity of the generated tool using human diploid fibroblasts and adipose-derived human mesenchymal stem cells. Finally, we demonstrated the possibility to apply our tool for personalized hormone screening by comparing the effects of natural progesterone and three synthetic analogs (medroxyprogesterone 17-acetate, 17α-hydroxyprogesterone caproate, dydrogesterone) on decidualization of six ESC lines obtained from patients planning to undergo the IVF procedure. To sum up, we developed the “all-in-one” genetic tool based on the MER20/MER39 expression cassette that provides the ability to predict the most appropriate hormonal cocktail for endometrial receptivity maintenance specifically and safely for the patient, and thus to define the personal treatment strategy prior to the IVF procedure.
Ruxolitinib Cream Has Dual Efficacy on Pruritus and Inflammation in Experimental Dermatitis
Authors: Scuron Monika D. , Fay Brittany L. , Connell Andrew J. , Peel Michael T. , Smith Paul A.
Published: February 2021

The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common chronic relapsing inflammatory skin disease, significantly impairs patients’ quality of life, with pruritus being a common complaint. The sensation of itch results from the interplay between epidermal barrier dysfunction, upregulated immune signaling and the activation of the central nervous system. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a central role in pro-inflammatory cytokine signaling in AD. Ruxolitinib cream is a potent and selective JAK1/2 inhibitor currently undergoing clinical evaluation in adults with mild-to-moderate AD (NCT03745638, NCT03920852 and NCT03745651). The efficacy of ruxolitinib cream was tested in murine models of acute and chronic dermatitis and was also characterized in an ex vivo human skin dermatitis model. Ruxolitinib cream was highly effective at ameliorating disease symptoms in multiple murine dermatitis models through downregulation of T helper (Th)2-driven inflammation, resulting in reduced skin thickening and decreased itch. Pathway analysis of mouse ear tissue and human skin explants underscored the role for ruxolitinib in ameliorating inflammation and reducing itch via modulation of the JAK-STAT pathway. Together, the data offer a strong rationale for the use of ruxolitinib cream as a potent therapeutic agent for the clinical management of atopic dermatitis.
Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses
Authors: Lin Chun-Yu , Huang Chung-Hao , Wang Wen-Hung , Tenhunen Jyrki , Hung Ling-Chien , Lin Chi-Chou , Chen Yu-Cheng , Chen Yen-Hsu , Liao Wei-Ting
Published: February 2021

Exposure to environmental hormones such as di(2-ethylhexyl) phthalate (DEHP) has become a critical human health issue globally. This study aimed to investigate the correlations between DEHP/mono-(2-ethylhexyl) phthalate (MEHP) levels and macrophage-associated immune responses and clinical manifestations in dengue virus (DV)-infected patients. Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In anin vitrostudy using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. MEHP-treated MDMs had lower antiviral Th17 response induction activity in mixed T-cell response tests. Thein vitrodata showed that MEHP increased DV viral load and decreased IL-23 release dose-dependently, and adding IL-23 to MEHP-exposed MDMs significantly reduced the DV viral load. MEHP also suppressed IL-23 expressionviathe peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. Further, the PPAR-γ antagonist GW9662 significantly reversed MEHP-induced IL-23 suppression and reduced the DV viral load. These study findings help to explain the associations between high MEHP levels and the high global burden of dengue disease.
Switchable Coumarins for Ratiometric pH Sensing
Authors: Mazza Mercedes M. A. , Cardano Francesca , Baker James D. , Giordani Silvia , Raymo Françisco M.
Published: February 2021

A fluorescent chromophore and a pH-sensitive heterocycle were integrated within a single covalent skeleton to generate four molecular switches with ratiometric fluorescence response. Upon acidification, the pH-sensitive heterocycle opens to shift bathochromically the absorption and emission bands of the fluorescent chromophore. As a result, an equilibrium between two species with resolved fluorescence is established with fast kinetics in aqueous environments. The relative amounts of the two interconverting forms and their relative emission intensities change with pH, providing the opportunity to probe this parameter ratiometrically with fluorescence measurements. Specifically, the resolved emissions of the two species can be collected in separate detection channels of the same microscope to map their ratio across a labeled sample and reconstruct its pH distribution ratiometrically with spatial resolution at the micrometer level. Additionally, the sensitivity of these molecular switches varies with the nature of the heterocyclic ring and with its substituents, allowing the possibility of regulating their response to a given pH range of interest with the aid of chemical synthesis. Thus, a family of valuable fluorescent probes for ratiometric pH sensing in a diversity of samples can emerge from the unique combination of structural and photophysical properties designed into our innovative molecular switches.
Clinical Features and Molecular Markers on Diffuse Midline Gliomas With H3K27M Mutations: A 43 Cases Retrospective Cohort Study
Authors: Wang Yuan , Feng Lan-lan , Ji Pei-gang , Liu Jing-hui , Guo Shao-chun , Zhai Yu-long , Sankey Eric W. , Wang Yue , Xue Yan-rong , Wang Na , Lou Miao , Xu Meng , Chao Min , Gao Guo-Dong , Qu Yan , Gong Li , Wang Liang
Published: February 2021

Purpose

Diffuse midline gliomas (DMG) with H3K27M mutations have been identified as a rare distinctive entity with unique genetic features, varied molecular alterations, and poor prognosis. The current study aimed to evaluate the clinical characteristics and profile of molecular markers on patients with a DMG harboring H3K27M mutations, and explore the impact of this genetic makeup on overall survival.

Methods

We retrospectively analyzed 43 consecutive patients diagnosed with a DMG harboring H3K27M mutations (age range 3 to 75 years) and treated in a tertiary institution within China between January 2017 to December 2019. Various clinical and molecular factors were evaluated to assess their prognostic value in this unique patient cohort.

Results

The median overall survival (OS) was 12.83 months. Preoperative Karnofsky Performance Score (KPS) and adjuvant radiotherapy were found to be independent clinical parameters influencing the OS by multivariate analysis (p = 0.027 and p < 0.001 respectively). Whereas extent of tumor resection failed to demonstrate statistical significance. For molecular markers, P53 overexpression was identified as a negative prognostic factor for overall survival by multivariate analysis (p = 0.030).

Conclusion

Low preoperative KPS, absence of radiotherapy and P53 overexpression were identified as predictors of a dismal overall survival in patients with DMG and H3K27M mutations.
SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer
Authors: Tran Arthur-Quan , Sullivan Stephanie A. , Chan Leo Li-Ying , Yin Yajie , Sun Wenchuan , Fang Ziwei , Dugar Sundeep , Zhou Chunxiao , Bae-Jump Victoria
Published: February 2021

SPR965 is an inhibitor of PI3K and mTOR C1/C2 and has demonstrated anti-tumorigenic activity in a variety of solid tumors. We sought to determine the effects of SPR965 on cell proliferation and tumor growth in human serous ovarian cancer cell lines and a transgenic mouse model of high grade serous ovarian cancer (KpB model) and identify the underlying mechanisms by which SPR965 inhibits cell and tumor growth. SPR965 showed marked anti-proliferative activity by causing cell cycle arrest and inducing cellular stress in ovarian cancer cells. Treatment with SPR965 significantly inhibited tumor growth in KpB mice, accompanied by downregulation of Ki67 and VEGF and upregulation of Bip expression in ovarian tumors. SPR965 also inhibited adhesion and invasion through induction of the epithelial–mesenchymal transition process. As expected, downregulation of phosphorylation of AKT and S6 was observed in SPR965-treated ovarian cancer cells and tumors. Our results suggest that SPR965 has significant anti-tumorigenic effects in serous ovarian cancer in vitro and in vivo. Thus, SPR965 should be evaluated as a promising targeted agent in future clinical trials of ovarian cancer.
Molecular Response of Skin to Micromachining by Femtosecond Laser
Authors: Wang Yutong , Wang Shaoyang , Zhu Yujie , Xu Hui , He Hao
Published: February 2021

Pulsed lasers at the near infrared (NIR) range have been widely used in dermatology. Ultrashort pulsed picosecond lasers are found with the specific ability of very effective activation of skin repair and remodeling along with significant photodamage. Femtosecond lasers, with a shorter pulse width, may be a promising alternative to current NIR lasers in clinic. In this study, we performed optical micromachining by a femtosecond laser at 1,030 nm to skin of live mice in two modes of scanning of focused laser and direct irradiation by unfocused laser. The acute and one-day delayed immune molecular responses of the skin to the micromachining are studied by immunofluorescence microscopy of the skin sections. Our data shows the focused laser can activate remodeling of skin without any significant immune responses. In contrast, the direct irradiation by the unfocused laser activate significant immune responses in the deep dermis with high regulation of interleukin. Those results suggest focused femtosecond laser is of good promising potential in activation of skin remodeling and repairing with little immune or physical damage.
Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops?
Authors: Platel Hervé , Eustache Marie-Loup , Coppalle Renaud , Viard Armelle , Eustache Francis , Groussard Mathilde , Desgranges Béatrice
Published: February 2021

Despite severe amnesia, some studies showed that Alzheimer Disease (AD) patients with moderate to severe dementia keep a consistent, but impoverished representation of themselves, showing preservation of the sense of identity even at severe stages of the illness. Some studies suggest that listening to music can facilitate the reminiscence of autobiographical memories and that stimulating autobiographical memory would be relevant to support the self of these patients. Consequently, we hypothesized that repeated participation to reminiscence workshops, using excerpts of familiar songs as prompts would participate to the enrichment of autobiographical memories, self-representation and sense of identity. We included a group of 20 AD patients with severe dementia residing in nursing homes. Their performances were compared to a control group of 20 matched (age, education, mood) healthy residents living in the same institutions. The experiment was conducted in three phases over a 2-week period. On phase 1, an individual assessment of sense of identity was proposed to each participant. On phase 2, participants joined musical reminiscence workshops (six sessions over 2 weeks for AD patients and 3 sessions over a week for controls). During the third phase (12 days after the first assessment), individual evaluation of autobiographical memory and a second assessment of sense of identity were proposed. Our results showed that, despite their massive amnesia syndrome, autobiographical memories of AD reached at the end of the 2 weeks the number and quality of those of matched controls. Moreover, we confirmed a continuity of self-representation in AD patients with a stable profile of the answers between the first and second individual assessments of sense of identity. However, the increase in number and episodic quality of autobiographical memories was not accompanied by an enrichment of the sense of identity. In a complementary study, new patients participated in the same paradigm, but using movie extracts as prompts, and showed very similar effects. We discuss all of these results with regard to the literature showing the significant impact of repetition on the reactivation of memory traces even in very amnestic AD patients at severe stages of the disease.
Measurement Invariance of Screening Measures of Anxiety, Depression, and Level of Functioning in a US Sample of Minority Older Adults Assessed in Four Languages
Authors: Cruz-Gonzalez Mario , Shrout Patrick E. , Alvarez Kiara , Hostetter Isaure , Alegría Margarita
Published: February 2021

Population aging in the US and its increase in racial/ethnic diversity has resulted in a growing body of literature aimed at measuring health disparities among minority older adults. Disparities in health outcomes are often evaluated using self-reported measures and, to attend to linguistic diversity, these measures are increasingly being used in languages for which they were not originally developed and validated. However, observed differences in self-reported measures cannot be used to infer disparities in theoretical attributes, such as late-life depression, unless there is evidence that individuals from different groups responded similarly to the measures—a property known as measurement invariance. Using data from the Positive Minds-Strong Bodies randomized controlled trial, which delivered evidence-based mental health and disability prevention services to a racially/ethnically diverse sample of minority older adults, we applied invariance tests to two common measures of anxiety and depression (the GAD-7 and the HSCL-25) and two measures of level of functioning (the Late-Life FDI and the WHODAS 2.0) comparing four different languages: English, Spanish, Mandarin, and Cantonese. We found that these measures were conceptualized similarly across languages. However, at the item-level symptom burden, we identified a non-negligible number of symptoms with some degree of differential item functioning. Spanish speakers reported more worry symptoms and less somatic symptoms for reasons unrelated to their psychological distress. Mandarin speakers reported more feelings of restlessness, and both Mandarin and Cantonese speakers reported no interest in things more often for reasons unrelated to their psychological distress. Mandarin and Cantonese speakers were also found to consistently report more difficulties performing physical activities for reasons unrelated to their level of functioning. In general, invariance tests have been insufficiently applied within psychological research, but they are particularly relevant as a prerequisite to accurately measure health disparities. Our results highlight the importance of conducting invariance testing, as we singled out several items that may require careful examination before considering their use to compare symptoms of psychological distress and level of functioning among ethnically and linguistically diverse older adult populations.
Low Mass Stars or Intermediate Mass Stars? The Stellar Origin of Presolar Oxide Grains Revealed by Their Isotopic Composition
Authors: Palmerini S. , Cristallo S. , Busso M. , La Cognata M. , Sergi M. L. , Vescovi D.
Published: February 2021

Among presolar grains, oxide ones are made of oxygen, aluminum, and a small fraction of magnesium, produced by the 26Al decay. The largest part of presolar oxide grains belong to the so-called group 1 and 2, which have been suggested to form in Red Giant Branch (RGB) and Asymptotic Giant Branch (AGB) stars, respectively. However, standard stellar nucleosynthesis models cannot account for the 17O/16O, 18O/16O, and 26Al/27Al values recorded in those grains. Hence, for more than 20 years, the occurrence of mixing phenomena coupled with stellar nucleosynthesis have been suggested to account for this peculiar isotopic mix. Nowadays, models of massive AGB stars experiencing Hot Bottom Burning or low mass AGB stars where Cool Bottom Process, or another kind of extra-mixing, is at play, nicely fit the oxygen isotopic mix of group 2 oxide grains. The largest values of the 26Al/27Al ratio seem somewhat more difficult to account for.
Doomed Youth: Antonio Cánovas, a Young Sportsman in Time of War in 1930s Spain
Authors: Viuda-Serrano Alejandro , Ibarrondo-Merino Iker
Published: February 2021

During the Spanish Civil War (SCW) 1936–1939, many young working-class sportsmen volunteered. They were both physically and politically active and some of them outstanding athletes. The search of these unknown men has just begun.Doomed Youthis a tribute to them and the first step toward a bigger attempt to better comprehend the role of sportsmen volunteers enlisted during the first months of the SCW, a fact that to date has received little scholar attention. Archival research, especially war combatants' family records as well as newspaper archives, oral memories of the protagonists left alive, and historical contextualization were defined as the appropriate methods to conduct the research. This paper is devoted to one of these young volunteers, Antonio Cánovas, recently dead in 2018 at the age of 98, whose life story in the 1930s and 1940s may be taken as the epitome of the young working-class sportsman of the cutting-edge regions of Spain in the first half of the 20th century: youngsters aware of their political and social rights whose dreams of social justice and active life were dashed by the war.
Comparison of Outcomes Between Anti-Nuss Operation and Modified Anti-Nuss Operation Using a Flexible Plate for Correcting Pectus Carinatum: A Retrospective Study
Authors: Wang Lei , Liu Juan , Shen Saie , Li Yao , Feng Tienan , Li Guoqing , Xiao Haibo , Hu Fengqing
Published: February 2021

Introduction: The anti-Nuss procedure has gradually been found to have several shortcomings in clinical practice. Accordingly, our department previously designed and introduced a new steel plate. However, there is limited evidence regarding its safety and efficacy. Thus, we aim to compare the efficacy and safety of the conventional anti-Nuss operation with those of a modified anti-Nuss operation using a flexible plate.

Methods: Patients with pectus carinatum who underwent surgery between January 2014 and August 2019 were consecutively enrolled in this single-center, retrospective study. In all, 53 patients underwent the modified procedure using the new steel plate (new procedure group), whereas 43 underwent the conventional anti-Nuss procedure (traditional procedure group). Outcome analysis was performed using SPSS to compare the intraoperative and postoperative short-term outcomes.

Results: All patients in the new procedure group had shorter operation duration (75.23 ± 11.90 vs. 82.45 ± 9.30 min, p = 0.008), postoperative hospitalizations (3.42 ± 0.95 vs. 4.64 ± 1.53 days, p = 0.039), and plate removal surgery durations (40.60 ± 3.47 vs. 60.30 ± 9.75 min, p = 0.041) than patients in the traditional procedure group. There were no significant differences in the length of incision, postoperative Haller index, cost, postoperative surgical outcome, and incidence of complications between the two groups.

Conclusion: Our data reveal that the main clinical outcomes were similar for after anti-Nuss operation and modified anti-Nuss operation. However, the modified procedure for pectus carinatum had a shorter operation duration, postoperative hospitalization, and plate removal surgery duration.