bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence Powered Automated and Early Diagnosis of Acute Lymphoblastic Leukemia Cancer in Histopathological Images: A Robust SqueezeNet‐Enhanced Machine Learning Framework
Authors: Mehan Vineet
Published: February 2025

The growing prevalence of acute lymphoblastic leukemia cancer worldwide underlines the critical need for early and more precise detection to counter this deadly disease. This study presents a robust SqueezeNet‐enhanced machine learning framework for automatically screening and classifying histopathological images for acute lymphoblastic leukemia. This work employs a deep learning (DL)–based SqueezeNet integrated with three machine learning (ML) models including neural network (NN), logistic regression (LR), and random forest (RF) for diagnosis. Combining DL and ML algorithms addresses the complexity of understanding histopathological images and the classification process. Evaluation metrics computed for acute lymphoblastic leukemia reveal a good classification accuracy (CA) of 99.3%. Results are further validated by confusion matrix (CM), calibration plot (CP), receiver operating characteristic (ROC) analysis, and comparative analysis with previous techniques. The proposed method has the potential to transform healthcare with more accurate diagnosis. It provides a robust framework for the classification of acute lymphoblastic leukemia, facilitating timely treatment options for patients.
Fault Diagnosis of Traction Motor Bearings Based on Shifted Rank‐1 Reconstruction
Authors: Zheng Shubin , Chen Xieqi , Zou Boyu , Zhong Qianwen , Peng Lele , Wu Liqun
Published: February 2025

Rolling bearings are one of the important components of rotating machinery, and effective bearing fault diagnosis is a necessary condition to ensure the normal operation of mechanical systems. In the rolling bearing operation process, the working conditions are usually harsh, and the sensor for collecting signals is usually placed on the outer surface of the mechanical system, resulting in the signal collected by the sensor eventually containing various interference components, increasing the difficulty of fault identification. Therefore, traditional bearing fault diagnosis methods make it difficult to detect periodic transient features from the signal spectrum. The traditional trajectory matrix with singular value decomposition (SVD) method cannot effectively diagnose the weak fault characteristics of bearings, which means that it is difficult to retain effective singular components. Therefore, a new singular value decomposition method based on shift rank‐1 matrix is proposed. To begin, generate the trajectory matrix using an approximation of the traversal segment length. The built approximation matrix is then approximated using a shift vector in order to produce a strict rank‐1 matrix, which is achieved by optimizing λ in low‐rank matrices. Through the singular values of the shift matrix, the fault impact signal may ultimately be reconstructed. Comparative analysis was conducted between the suggested technique and other approaches via quantitative and qualitative evaluation of the algorithm’s performance on simulated and experimental data. In spite of severe background noise (−20 dB), the findings demonstrate that this approach can still recover fault impact signals without requiring a fixed traversal segment length.
Figure S2 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Figure 2 shows Venn diagrams of elevated genes in drug-treated cells.
Figure 4 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Talazoparib treatment upregulates CXCL10 gene expression in three, BRCA wild-type HGSC cell lines compared with veliparib treatment. A and D, OVCAR3, (B and E) OVCAR4 cells, and (C and F) CAOV3 cells were treated with a vehicle control (DMSO) or 10 μmol/L Veliparib or 2 μmol/L Talazoparib. Cell pellets and supernatants were collected 48 hours after drug treatment. A–C, Two micrograms of total RNA extracted from cell pellets was reverse transcribed to cDNA and then analyzed by qRT-PCR for CXCL10 and GAPDH expression. D–F, Supernatants were tested for CXCL10 (IP-10) protein levels using an ELISA assay. A five-parameter logistic curve fit was used to analyze these results. *, P < 0.05; **, P < 0.01; ns, not statistically significant.
Data from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Abstract
Immune checkpoint inhibitors (ICI) have revolutionized treatment for several tumor indications without demonstrated benefit for patients with ovarian cancer. To improve the therapeutic ratio of ICIs in patients with ovarian cancer, several different clinical trials are testing combinations with poly(ADP-ribose) polymerase (PARP) inhibitors. Comparing the immunomodulatory effects of clinically advanced PARP inhibitors (PARPi) may help to identify the best partner to combine with ICIs. We examined the treatment effect of talazoparib (a PARP trapper) and veliparib (a solely PARP enzymatic inhibitor) in homologous recombination deficient (HRD) and homologous recombination proficient high-grade serous tubo-ovarian carcinoma (HGSC) cell lines on immune-related gene expression. We discovered and validated that CXCL8, IL-6, and TNF gene expression were upregulated after talazoparib treatment in both OVCAR3 (HRD) and CAOV3 homologous recombination proficient HGSC cell lines. In contrast, veliparib treatment slightly elevated similar genes exclusively in an HRD HGSC cell line model. We expanded these studies to include olaparib, a PARP trapper less potent than talazoparib, and found effects specific to COV361 (BRCA1 mutant) and OVCAR8 (BRCA1 methylated) HGSC cells but not all HRD HGSC cell lines. Our studies also identified differences among PARP trappers versus veliparib on augmenting CXCL10 expression. Finally, we show that talazoparib modulates the CXCL10 response in cGAS-defective cell lines, independent of the cGAS-STING pathway. These mechanistic studies advance our understanding of how different PARPis affect the immune system in various genetic backgrounds.
Significance:
This work highlights how different PARPis, especially talazoparib, modulate immune-related gene expression in ovarian cancer cells, independent of the cGAS-STING pathway. These findings may improve our understanding of how different PARPis affect the immune system in various genetic backgrounds.
Severe Acute Pancreatitis Complicated by Multiple Intra-Abdominal Hemorrhages
Authors: Wang Cong-Yu , Gu Yin , Yan Rui-Peng , Li Xin , He Fei , Feng Xiang-Lan , Zhang Gen , Cui Yun-Feng
Published: February 2025

Introduction: Intra-abdominal hemorrhage is a rare yet life-threatening complication of acute pancreatitis (AP), with a higher prevalence in cases of severe acute pancreatitis (SAP). This condition is primarily caused by vessel wall erosion and rupture of pseudoaneurysms (PSAs). However, SAP cases involving multiple sequential arterial hemorrhages are extremely rare. This condition is primarily brought on by the process of vessel wall degeneration and the development of PSAs. Nonetheless, SAP necessitating multiple episodes of arterial bleeding is very uncommon. Case Presentation: Here is the case history of a 31-year-old man already being treated for SAP. His condition was then complicated by massive, frequent intra-abdominal bleeding. The patient initially presented to the hospital with SAP. He was transferred to the intensive care unit for proper management. Massive intra-abdominal bleeds occurred on the 31st, 45th, and 60th days during hospitalization. The maximum blood loss was 1,500 mL. In each of the instances, digital subtraction angiography (DSA) embolization was carried out after the bleeding source had been verified. In order to manage SAP, continuous percutaneous drainage and staged pancreatic necrosectomy were undertaken for 6 months. No recurrence of intra-abdominal hemorrhage was detected. Infection of the abdominal cavity was properly controlled. The patient left the hospital in good condition. Conclusion: Spontaneous bleeding in the abdominal cavity is a severe and life-threatening complication of SAP. This is often caused by vessel wall erosion. In such cases, DSA plays a crucial role in diagnosis and management. Besides precisely locating the bleeding source, one can perform a much-needed embolization immediately. Consequently, the disease is under total control, and the patient is much more likely to survive.
Visual vertigo is not correlated with perception of dynamic verticality
Authors: Chang Tzu-Pu , Hong Ying-Chi , Kuo Yu-Hung , Schubert Michael C.
Published: February 2025

Introduction: We conducted a prospective study determining the relationship between severity of visual vertigo and extent of visual dependence by comparing the visual vertigo analogue scale (VVAS) with the dynamic subjective visual vertical (dSVV) test.
Methods: Seventy-six patients with chronic dizziness (without peripheral or central vestibular lesions) and 43 healthy controls completed VVAS and dSVV testing. The VVAS uses nine visual analogue scales to query visual vertigo across nine specific situations. The dSVV measures visual dependence under three conditions: static background, counterclockwise (CCW) rotating background, and clockwise (CW) rotating background (20 o/s). Finally, each patient completed a simulator sickness questionnaire (SSQ) to evaluate the dizziness induced from the dSVV. VVAS, dSVV, and SSQ were compared between the patient and the control groups. Among the patient group, the correlation between VVAS and dynamic SVV were determined. Associations of outcomes measures and gender, age, and migraine were also assessed.
Results: Patients with dizziness had significantly greater VVAS (16.9 VS 1.6, p < 0.001) and SSQ (25.7 VS 6.5, p < 0.001) scores, yet less deviation of dSVV (CCW background: -9.2 VS -11.5, p = 0.05; CW background: 7.4 VS 10.1, p = 0.02) than controls. In the patient group, VVAS was not correlated with dynamic SVV for either CCW (r = 0.12, p = 0.30) or CW backgrounds (r = -0.01, p = 0.92). During CCW rotation the SVV deviation was greater in older-aged patients and slightly greater in female. During CW rotation the SVV deviation was less in the patients with migraine. Conclusion: In chronic dizzy patients that have no measurable peripheral or central vestibular lesion, severity of visual vertigo is not correlated with visual dependence.
Image findings of breast cancer-related elastosis: A case report
Authors: Takano Yu , Oura Shoji , Honda Mariko
Published: February 2025

A 70-year-old woman visited the Rinku General Medical Center for the evaluation of her left palpable breast tumor. Mammography (MMG) showed an irregular mass with segmental distribution of pleomorphic calcifications. The tumor was more clearly depicted on cranio-caudal (CC) MMG than on medio-lateral-oblique (MLO) MMG. Ultrasound showed a lobulated mass with low internal echoes, echogenic spots, and at least focally enhanced posterior echoes. Magnetic resonance imaging (MRI) of the tumor showed low signal intensity on T1-weighted images and no high signal intensity on T2-weighted images and a rim enhancement pattern on subtraction images. Pathological examination of the core needle biopsy specimen showed atypical cells growing in a tubule forming fashion. The patient underwent mastectomy and, due to the cytologically proven lymph node metastasis, axillary dissection. Postoperative pathological study showed that the tumor had large elastosis areas encompassed by malignant cells. Diagnostic physicians should note that breast cancer-related elastosis is more clearly depicted on CC MMG than on MLO MMG, has possible enhanced posterior echoes, and shows low and no high signal intensities on T1-and T2-weighted images, respectively.
Hereditary Alpha Tryptasemia: Survey of Concomitant Genetic Testing
Authors: Butterfield Joseph H. , Bhasin Arveen K. , Ishmael Leah L. , Squire Jacqueline D.
Published: February 2025

Background Hereditary alpha tryptasemia (HαT) affects 4-6% of the general population. Inherited as a mendelian dominant, HαT has a variable phenotypic expression. Many patients have no obvious symptoms. There is a dearth of reports of possible co-inheritance of other genetic abnormalities.
Methods We examined records of 69 Mayo Clinic patients with HαT for the results of any additional genetic studies obtained during routine or focused evaluations. Clinical records of patients evaluated for baseline tryptase values > 8 ng/mL testing positive for the TPSAB1 mutation were reviewed. Screening genetic tests obtained during standard care and/or for evaluation of clinical symptoms were recorded as well as inciting symptoms that led to tryptase determination, the serum tryptase level, alpha and beta tryptase gene copy numbers and the urinary mast cell mediator metabolites.
Results Bone marrow biopsies for systemic mastocytosis and the presence of either a KIT Asp816Val, or Janus Kinase 2 Val617Phe mutation were negative. Genetic tests were diverse and included nearly 1000 suspect genes in one case and one to several hundred in others. There was no genetic testing in 19 patients and normal genetic test findings in 37 patients. A group of 8 patients showed at least one genetic abnormality, and in a group of 5 patients both normal and abnormal genetic findings were present. There was no clustering of genetic tests or relation to the inciting symptoms.
Conclusion Genetic testing, often extensive, was obtained in 73% of these HαT patients. Most of these results were normal and did not suggest the presence of a concomitant genetic disorder.
Skin transcriptomic analysis reveals altered fatty acid metabolism pathways in mice subjected to sleep fragmentation
Authors: Lee Da-Been , Yoo Seung-Lim , Heo June Seok , Lim Ja-Yun , Pyo Sang Shin , Moon Ji Sun , Lee Mi-Ran , Kim Jinkwan , Kim Suhng-Wook , Yoon Dae-Wui
Published: February 2025

Introduction
Sleep fragmentation (SF) is a hallmark of sleep disorders and has been associated with systemic health issues, but its specific impact on skin health remains unclear. This study aimed to investigate whether SF impairs skin barrier function and identify the biological pathways involved in SF-induced skin damage.
Methods
Twenty-four 6-week-old male BALB/c mice were divided into home cage control (HC) and SF groups. SF was induced using a commercially available SF chamber. Skin barrier function was assessed by measuring transepidermal water loss (TEWL) at 4 and 8 weeks. Epidermal thickness and dermal collagen density were also measured. Total RNA sequencing (RNA-Seq) and bioinformatics analysis were conducted to identify the affected pathways.
Results
TEWL was significantly higher in the SF group than in the HC group at 8 weeks. Epidermal thickness and dermal collagen density were significantly lower in the SF group than in the HC group. In the SF group, 133 differentially expressed genes were identified, of which 14 were upregulated and 119 were downregulated. RNA-Seq and bioinformatics analysis revealed an altered fatty acid metabolism pathway in the skin of mice subjected to chronic SF. This was validated through quantitative real-time polymerase chain reaction.
Conclusion
SF caused physiological and histological changes in the skin, altering the fatty acid metabolism pathway. The role of this pathway in SF-induced skin damage requires further exploration.
Rapid On-Site Evaluation with Pancreatic Fine-Needle Biopsies: Successes and Challenges
Authors: Helland T. Leif , Zhang M. Lisa , Pitman Martha B. , Torous Vanda F.
Published: February 2025

Background: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using larger, next-generation cutting needles is a minimally invasive method for the diagnosis of pancreatic lesions. Rapid on-site evaluation (ROSE) is employed to render preliminary diagnoses, ensure specimen adequacy, and triage tissue for ancillary testing and can be performed on FNB cores. Given the difficulty of pancreatic cytology and the novelty of ROSE with these larger cutting needles, this study was performed to evaluate discrepancies between ROSE and the final diagnosis to uncover challenging diagnostic areas.
Methods: Final reports from pancreatic FNBs with ROSE between 1/2019-12/2021 were reviewed, and the ROSE and final diagnoses were compared. Cases were categorized into non-diagnostic (ND), negative for malignancy (NEG), atypical, neoplastic (NEO), suspicious for malignancy (SFM), and positive for malignant cells (POS). A major discrepancy was defined as a ND/NEG versus NEO/SFM/POS interpretation.
Results: 454 cases were identified. The ROSE versus final diagnosis breakdown was as follows: ND/NEG 18.7% versus 16.3%, atypical 6.4% versus 5.1%, NEO 10.8% versus 11.9%, SFM 4.4% versus 2.0%, and POS 59.7% versus 64.8%. The concordance rate was high at 96.9% with only 14 (3.1%) major discrepancies which included 6 due to interpretive error, 3 to sampling error, and 5 due to a combination of both. While the majority of lesions in the cohort were conventional ductal adenocarcinomas (76%), there was an over-representation of non-ductal tumors constituting major discrepancies (6/14; 42.9%).
Conclusions: ROSE using pancreatic EUS-FNB is possible and provides an accurate interpretation in most cases. Diagnostic challenges remain with non-ductal tumors.
The prediction of hematoma growth in acute intracerebral hemorrhage: from 2-dimensional shape to 3-dimensional morphology
Authors: Yang Wen-Song , Shen Yi-Qing , Liu Qing-Jun , Ma Yong-Bo , Huang Jun-Meng , Wu Qing-Yuan , Wang Jing , Huang Chao-Yi , Zhao Li-Bo , Li Qi , Xie Peng
Published: February 2025

Introduction: The relationship between the 3-dimensional morphological features of hematoma and hematoma growth (HG) remains unclear. We aim to quantitatively assess the predictive value of 3-dimensional hematoma morphology for HG among patients with intracerebral hemorrhage (ICH).
Methods: Our study comprised 312 consecutive ICH patients. Using semi-automated volumetric analysis software, we measured hematoma volumes and delineated the region of interest. We employed Python software to extract shape features, and receiver operating characteristic curve analysis to assess the predictive performance of hematoma morphology for HG. P value < 0.05 was considered statistically significant.
Results: Sphericity and SurfaceArea emerged as the most effective 3-dimensional hematoma morphological predictors for HG. Optimal cutoff points relating to HG were Sphericity ≤ 0.56 and SurfaceArea > 55 cm2. We subsequently constructed the 3-dimensional morphology models, including the probability of hematoma morphology (PHM) and the probability of comprehensive model (PCM), to predict HG. The PHM model outperformed the irregular hematoma (p = 0.007), island sign (p = 0.032), and satellite sign (p < 0.001) in predictive accuracy for HG. Amongst all prediction models, the PCM presented the highest predictive value for active bleeding.
Conclusions: The Sphericity≤0.56 and SurfaceArea >55 cm2 could represent the optimal threshold for HG prediction. PHM was considered a reliable 3-dimensional morphology model for HG prediction. PCM tended to be a better model for risk stratification of active bleeding in acute ICH patients.
Elogio das humanidades - homenagem a Sérgio Paulo Rouanet
Authors: Perine Marcelo
Published: February 2025

O texto parte de uma breve reflexão sobre as origens e o legado grego para o humanismo na tradição ocidental de filosofia, passa por uma compreensão da nossa humanidade a partir da escolha da razão contra a violência e desemboca num elogio dos estudos humanistas como via de superação da violência em nossa cultura, a partir de um confronto do texto “Reinventando as humanidades”, de Sérgio Paulo Rouanet (As razões do Iluminismo), com alguns textos de Eric Weil sobre os estudos humanistas.
Acupuntura no linfedema de membro superior avaliado pela termografia e bioimpedância espectroscópica: relato de caso
Authors: Marques Jaqueline Covatti , Barbosa Everton Horiquini , Gomes Guilherme Gallo Costa , Silva Gabriel Pádua da , Sarri Almir José
Published: February 2025

O linfedema secundário, é a maior e mais importante morbidade associada ao tratamento para o câncer de mama com impacto direto na qualidade de vida destas pacientes.
Atendimento fisioterapêutico em intervenção precoce na Casa da Esperança de Santos: relato de caso
Authors: Lopes Eliane Calumby de Souza , Apa Maria Fernanda de Mello , Menezes Ilma , Siqueira Paulo Santos de , Santos Maria Lúcia Leal dos
Published: February 2025

A intervenção precoce e a avaliação sistemática em programas de follow up favorecem o desenvolvimento de crianças prematuras e de risco. Embora os avanços da tecnologia aumentem as taxas de sobrevivência, o maior desafio são as taxas de morbidade que representam 50% destas crianças com atrasos em domínios motores, cognitivos, comportamentais e outros diagnósticos.
Avaliação da satisfação do usuário com a tecnologia assistiva: cadeira de rodas motorizada
Authors: Fernandes Luísa Alves , Ribeiro Darlan Martins
Published: February 2025

A Tecnologia Assistiva (TA) engloba uma variedade de recursos, estratégias, e serviços destinados a promover a funcionalidade e participação de pessoas com incapacidades, visando à autonomia, qualidade de vida e inclusão social. Dentro desse contexto, a cadeira de rodas motorizada (CRM) se destaca como um dispositivo essencial de mobilidade alternativa, projetado para melhorar a locomoção tanto em ambientes internos quanto externos, sendo prescrita por Terapeutas Ocupacionais habilitados.
Depressão, quedas e risco de quedas em mulheres idosas
Authors: Tesser Ramayana Bazeggio , Santos Brenda Felski dos , Moreira Gislaine Costa , Velasquez Jorge Luiz , Mineiro Lindomar
Published: February 2025

A população idosa apresenta risco aumentado de quedas por apresentarem maiores fatores de risco, como distúrbios da marcha, fraqueza muscular, sarcopenia, tontura, síncope, hipotensão postural, depressão, comprometimento cognitivo, distúrbio do sono, uso de medicamentos e osteoporose, este último mais comum em mulheres no período pós-menopausa. A relação entre menopausa e o risco de quedas se dá pela alteração da composição corporal que ocorre nesse período após a queda dos níveis de estrogênio. A depressão é prevalente em idosos e manifesta-se com sintomas como medo de cair, disfunção cognitiva, sono prejudicado e desnutrição, levando a um prejuízo da marcha.
Eficácia do dispositivo robótico Armeo®Spring na reabilitação do membro superior espástico após AVE: relato de caso
Authors: Marques Israel de Souza , Lima Thássia Cristina Farias , Marques Jaqueline Covatti , Silva Larissa Russo Veloso e , Barbosa Everton Horiquini
Published: February 2025

O AVE (Acidente Vascular Encefálico), uma desordem cerebrovascular de caráter trombótico ou hemorrágico, multifatorial envolvendo influências poligênicas e ambientais, sendo o distúrbio neurológico incapacitante mais comum. Por exercerem forte impacto sobre a saúde da população, as doenças cerebrovasculares são mais incapacitantes do que fatais, 2 tendo como sequela principal hemiparesia ou hemiplegia, acarretando com isso perda de produtividade e maiores custos em saúde coletiva. No campo da reabilitação o uso de diferentes técnicas sensório-motoras demostraram avanços significativos na recuperação dos membros superiores, incluindo movimentos repetitivos intensivos, terapia de movimento induzido por restrição e terapia robótica assistida. Os robôs são frequentemente usados em associação com ambientes interativos, a fim de fornecer significados funcionais as tarefas de treinamento. Essa abordagem tem sido utilizada na neurorreabilitação há mais de 15 anos com o propósito de recriar condições favoráveis à aprendizagem motora.
Evidência do método TheraSuit® na paralisia cerebral em uma criança diparética espástica: estudo de caso
Authors: Cruz Jackeline Silva , Contenças Thaís Santos , Silva Elaine Cristina , Torre Cláudia Alcântara de , Antunes Gisele Ladik
Published: February 2025

A Paralisia Cerebral (PC) refere-se a uma desordem no desenvolvimento do controle motor e da postura, resultante de uma lesão cerebral não progressiva que pode ocorrer desde a concepção até os dois anos de idade, contribuindo para limitações na funcionalidade e aparecimento de comorbidades.
Mídias sociais na telerreabilitação: análise de implicações ético-profissionais em serviço de reabilitação em Teresina/PI
Authors: Moraes Lucas Levy Alves de , Visgueira Ana Raquel Lopes , Lopes Leylane Auzeni Mendes Rilzer , Rodrigues Leonardo Raphael Santos , Alencar Francisco José
Published: February 2025

Toma-se como marco metodológico na relação profissional de saúde e paciente, o aproveitamento da formação de redes sociais no contexto virtual. Constituem-se como uma variedade de ferramentas contribuintes das malhas de comunicação capazes de criar interrelações, objetivos e valores. Por meio do encurtamento emissor-receptor, impactaram diretamente na educação em saúde, bem como no suporte à funcionalidade.
Síndrome do túnel do carpo: uma nova abordagem em relação à classificação neurofisiológica
Authors: Ferreira Luciana Borges , Ferreira Anthero Sarmento
Published: February 2025

A Síndrome do Túnel do Carpo (STC) é caracterizada pela compressão do Nervo Mediano ao nível do punho, sendo a mononeuropatia compressiva mais comum. A prevalência global da STC na população em geral pode variar de 2 a 5%. A Eletroneuromiografia, por meio dos estudos de condução nervosa e da eletromiografia (EMG), é o exame de escolha para definição da topografia, do grau de severidade e do prognóstico da lesão nervosa. Ao longo dos anos, várias classificações de intensidade da STC foram propostas, entretanto ainda não há uma padronização universal.
Toxina Botulínica do tipo A para o tratamento de espasticidade em pacientes pós acidente vascular cerebral: uma revisão sistemática
Authors: Aguiar Letícia , Zamarian Carmen Costa , Ferreira Lucas Araújo
Published: February 2025

A espasticidade nos membros inferiores é uma condição frequentemente observada em indivíduos que sofreram acidente vascular cerebral (AVC). Essa manifestação pode ter um impacto significativo nas habilidades de locomoção, equilíbrio, marcha e, consequentemente, na capacidade de realizar atividades cotidianas.
Tratamento com Toxina Botulínica em pacientes pós acidente vascular cerebral no CREFES
Authors: Cabral Fernando Bermudes , Maia Raphael de Paula Doyle , Oliveira Rosimara Loureiro de , Pereira Cristiane Chaves , Lee Soo Yang
Published: February 2025

Espasticidade é uma complicação comum após um Acidente Vascular Cerebral (AVC), afetando cerca de 25% dos sobreviventes. Compromete a qualidade de vida, causando rigidez muscular, postura inadequada dos membros, dor, dificuldade de higiene e limitações no auto-cuidado e tarefas diárias. O uso da toxina botulínica tipo A (TBA) é tratamento padrão para esta condição embora ainda pouco difundido. É um tratamento eficaz, seguro, trazendo inúmeros benefícios, como o ganho de função e a melhora na qualidade de vida.
Uso de emplastro de Lidocaína em ombralgia: um relato de caso
Authors: Nishizawa Lucas Eiti , Akamine Eduardo Hideyuki , Cheng Leonardo Honorato , Fonseca Marcos Matheus da
Published: February 2025

As neuropatias periféricas possuem diferentes causas possíveis, como diabetes mellitus, deficiências vitamínicas, autoimunidade, infecções, toxinas, traumas etc. Os sintomas variam dependendo dos nervos afetados, mas podem cursar com queixas como queimação, choque, formigamento, alodínea, adormecimento e perda de força muscular.
Associations of a Composite Stress Measurement Tool With Cardiovascular Risk Factors and Outcomes: Findings From the Dallas Heart Study
Authors: Eleazu Ijeoma , Ayers Colby , Navar Ann Marie , Salhadar Karim , Albert Michelle , Carnethon Mercedes , Brown E. Sherwood , Ogbu Nwobodo Lucy , Carter Spencer , Bess Courtney , Powell‐Wiley Tiffany M. , de Lemos James A.
Published: February 2025

Background

Most data linking chronic stress with cardiovascular disease (CVD) risk factors and outcomes have focused on single‐domain stress measurements. We evaluated the association between a novel composite measure of chronic perceived stress and CVD risk factors and outcomes in a diverse population.

Methods and Results

Individual chronic stress subcomponents (generalized stress, psychosocial, financial, and neighborhood stress) were standardized and integrated to create a novel composite stress score (CSS). Participants from the DHS (Dallas Heart Study) phase 2 (2007–2009) visit without prevalent CVD who completed chronic stress questionnaires were included (n=2685). Associations between CSS and demographics, cardiac risk factors, and health behaviors were assessed in multivariable analyses. Cox proportional hazards models adjusting for traditional risk factors were used to determine associations of the CSS with adjudicated atherosclerotic CVD and global CVD (atherosclerotic CVD, heart failure, and atrial fibrillation) outcomes. CSS was higher among participants who were younger, women, and Black or Hispanic individuals, with lower income and educational attainment (
P
<0.0001 for each). In multivariable regression models adjusting for age, sex, race and ethnicity, income and education, higher CSS associated with hypertension, smoking, higher body mass index, hemoglobin A
1C
, high‐sensitivity C‐reactive protein, and sedentary time (
P
<0.01 for each). Over a median follow‐up of 12.4 years, higher CSS associated with atherosclerotic CVD (adjusted hazard ratio [HR]. 1.22 per SD [95% CI, 1.01–1.47]) and global CVD (adjusted HR, 1.20 [95% CI, 1.03–1.40]). No interactions were seen between CSS, demographic factors, and outcomes.

Conclusions

Composite measures of chronic stress are higher in vulnerable populations and may help identify individuals at risk for CVD who may benefit from enhanced prevention strategies.
On the biogeography of earthworms of the primitive genus Drawida Michaelsen, 1900 (Clitellata: Moniligastridae) in the Indian subcontinent
Authors: NARAYANAN S. PRASANTH , KUMARI SHAILJA , KURIEN VIJO T. , THOMAS A.P. , PALIWAL R. , JULKA J.M.
Published: February 2025

Among the various Indian earthworm genera, the moniligastrid earthworm genus Drawida is the most species rich and has undergone extensive species radiation in Peninsular India. It is believed that Drawida entered Peninsular Indian landmass after the suturing of Indian plate with Laurasia during the Tertiary period in the Cenozoic Era. There are a number of hypotheses about the occurrence of various wet zone species in Peninsular India and its disjunct distribution in peninsula, northeast India and Sri Lanka. Here in this work, based on the thorough analysis of various available literatures on the various knowledge domains, we are further discussing the biogeography of Drawida in the Indian subcontinent in detail. We postulate that the Drawida species entered the Indian peninsula through the north-eastern corner of present-day India, during the middle Miocene epoch (during Burdigalian age: ca. 16 Ma) and taken the Eastern Ghats-east coast route to colonise the Western Ghats mountain ranges and undergone rapid diversification. Sri Lanka holds lone two endemic Drawida species/subspecies, and it is assumed that Drawida could not colonize Sri Lanka as it separated from the mainland India in the Miocene and only connected with mainland during several Pleistocene periods of low sea level. Hence the species occurring in Sri Lanka would have been carried there from the mainland India. Populations of Drawida species from Western Ghats, Eastern Ghats, north-eastern hills of India and Sri Lanka need to be sampled and studied in detail making use of the modern molecular techniques, which can solve many problems in the phylogeny and their biogeographical relationships.
Annotated checklist of the earthworms (Annelida: Clitellata: Oligochaeta) from Hispaniola: a brief review and remarks
Authors: ÁLVAREZ-ABREU ONIEL , CARRERA-MARTÍNEZ ROBERTO
Published: February 2025

Here, we present an annotated checklist and a brief literature review of earthworms known from the Caribbean island of Hispaniola. A total of 22 species are recorded, with one uncertain species record. Among these species, only 11 are considered native or endemic to the island. Patterns of distribution within Hispaniola are therefore preliminary. Nonetheless, of the 22 recorded species so far, eight are found exclusively in the Dominican Republic and six are restricted to Haiti. The total number of earthworm species on Hispaniola is considerably lower than the known diversity of the other Greater Antilles islands. However, the lower species richness on the island is attributed to limited work and absence of local experts. Systematic surveys will be needed to better understand the basic earthworm diversity of Hispaniola.
Shooting the phantom: what is Octolasion tyrtaeum?
Authors: SZEDERJESI TÍMEA , CSUZDI CSABA
Published: February 2025

Our study follows the history of the species name tyrtaeum, from the scanty original description as Enterion tyrtaeum by Savigny, 1826 through the loss of type specimen, additional description by Ribaucourt, confusion in the later literature, suggested synonymy with O. lacteum and different opinions of the different authors. Our molecular phylogenetic study within the genus Octolasion reflects the inconsistency in the name usage and shows that O. lacteum and O. tyrtaeum can’t be separated genetically. As a solution of the problem, the name E. tyrtaeum is suggested to be treated as a Lumbricus species incertae sedis.
Annotated Checklist of the Earthworms (Annelida: Clitellata: Megadrili) of Nepal
Authors: SINGH ANKIT KUMAR , KHANAL LAXMAN
Published: February 2025

This checklist of earthworms in Nepal was compiled from existing literature and documents 24 species across five families: Moniligastridae, Acanthodrilidae, Almidae, Lumbricidae, and Megascolecidae, found in various regions of the country. The family with the highest diversity is Megascolecidae, which includes nine species, followed by Lumbricidae with seven, and Acanthodrilidae with six species. Almidae and Moniligastridae each have one species represented. Four species—Drawida nepalensis, Eutyphoeus lippus, Eutyphoeus nepalensis, and Eutyphoeus pharpingianus—were first described taxonomically in Nepal and were considered endemic to the region. However, Drawida nepalensis, Eutyphoeus nepalensis, and Eutyphoeus pharpingianus have since been reported in other countries as well. Despite this documentation, Nepal remains underexplored in terms of earthworm diversity and lacks thorough taxonomic studies based on both morphology and molecular systematics. Therefore, this checklist serves as an important reference for future morphological and molecular taxonomic research on earthworms in Nepal.
Airborne and Ground Measurements for Vertical Profiling of Secondary Ice Production during Ice Pellet Precipitation
Authors: Lachapelle M. , Nichman L. , Girouard M. , Nguyen C. , Ranjbar K. , Bliankinshtein N. , Bala K. , Thériault J. M. , French J. R. , Minder J. R. , Wolde M.
Published: February 2025

During freezing rain, secondary ice produced by the fragmentation of freezing drops (FFD) can initiate a chain reaction, potentially transitioning freezing rain into ice pellets. Including this process in numerical weather prediction models is challenging due to the uncertainty of this mechanism. To bridge this gap, this study aims to evaluate the efficiency of the FFD process during ice pellet precipitation using measurements collected onboard the National Research Council Canada (NRC) Convair-580 research aircraft during the 2022 Winter Precipitation Type Research Multiscale Experiment (WINTRE-MIX). Below the supercooled raindrops freezing altitude, in situ probes measured a bi-modal particle size distribution. Observations from imaging and optical-array probes show that most particles smaller than 500 µm in diameter were non-spherical ice crystals, in concentration of ~500 L−1. In contrast, most particles larger than 500 µm were identified as fractured ice pellets and ice pellets with bulges, which suggested the occurrence of the FFD process. A conceptual model is then developed to show that five to eight fragments of ice were produced for each freezing drop. Two existing parametrizations of the FFD process are also tested. It is shown that one parameterization would result in less ice crystals than the measured number concentration, while the second one would result in too many ice crystals. Adjustments to these parametrizations are computed based on the collected observations. This analysis will be valuable for including the FFD process into simulations of freezing rain, ice pellets, and other weather phenomena where this process plays a significant role.
An alternative Ensemble Streamflow Prediction approach using improved subseasonal precipitation forecasts from the North America Multi-Model Ensemble Phase II
Authors: Zhang Lujun , Yang Tiantian , Gao Shang , Fan Ming , Lu Dan , Xu Hongmei , Xiao Chan
Published: February 2025

Streamflow forecasting at a subseasonal timescale (10 to 30 days into the future) is important for various human activities. The Ensemble Streamflow Prediction (ESP) is a widely applied technique for subseasonal streamflow forecasting. However, ESP’s reliance on the randomly resampled historical precipitation limits its predictive capability. Available dynamical subseasonal precipitation forecasts provide an alternative to the randomly resampled precipitation in ESP. Prior studies found the predictive performance of raw subseasonal precipitation forecast is limited in many regions such as the central south of the U.S., which raises questions about its effectiveness in assisting streamflow forecasting. To further assess the hydrologic applicability of dynamical subseasonal precipitation forecasts, we test the subseasonal precipitation forecast from North America Multi-Model Ensemble Phase II (NMME-2) at four watersheds in the central south region of the U.S. The subseasonal precipitation forecasts are post-processed with Bias Correction and Spatial Disaggregation (BCSD) to correct bias and improve spatial resolution before replacing the randomly resampled precipitation in ESP for streamflow predictions. The performance of the resulting streamflow predictions is benchmarked with ESP. Evaluation is conducted using Kling-Gupta Efficiency (KGE), Continuous Ranked Probability Score (CRPS), probability of detection (POD), false alarm ratios (FAR), as well as reliability diagrams. Our results suggest that BCSD-corrected subseasonal precipitation forecasts lead to overall improved streamflow predictions due to added skills in winter and spring. Our results also suggest that BCSD-corrected subseasonal precipitation forecasts lead to improved predictions on the occurrence of high-percentile streamflow values above 75%. Overall, BCSD-corrected subseasonal precipitation has shown promising performance, highlighting its potential broader applications for river and flood forecasting.
MicroRNAs in serum and tissue can differentiate splenic hemangiosarcoma from other splenic masses in dogs
Authors: Ludwig Latasha , Treleaven Heather , Khachadoorian Arlene , Degasperi Brigitte , Walter Ingrid , Stuart Deirdre , Foster Robert A. , Wood Robert Darren , Ali R. Ayesha , Wood Geoffrey A.
Published: February 2025

Splenic masses are common in dogs and vary dramatically in their clinical behavior. Clinically, and even with histology, it can be challenging to differentiate between benign and malignant splenic masses. Hemangiosarcoma (HSA), the most common malignancy of the spleen, is a very aggressive tumor with a poor prognosis. We hypothesize that microRNAs (miRNAs) in mass tissue and serum can differentiate between HSA and other splenic masses. Fifty-nine miRNAs were investigated by reverse-transcription followed by real-time quantitative polymerase chain reaction (RT-qPCR) in serum and/or tissue from dogs with HSAs (serum n = 24 and tissue n = 17; postsplenectomy serum n = 11), lymphomas (serum n = 8 and tissue n = 11), nonangiomatous nonlymphomatous sarcomas (serum n = 6 and tissue n = 10), histiocytic sarcomas (tissue n = 4), benign splenic masses (myelolipomas, nodular hyperplasia, and hematomas; total serum n = 21 and total tissue n = 35), and normal dogs (serum n = 14 and tissue n = 7). Numerous miRNAs were differentially expressed in serum and tissue of HSA cases compared to those with other splenic masses or normal spleens. In serum, our 5-miRNA model (miR-135a-5p, miR-10a, miR-450b, miR-152-3p, and miR-126-5p) accurately classified 100% (24/24) of dogs with HSA from normal dogs and those with a benign splenic mass (recall = 1 for HSA). The overall accuracy of the model was 86%. In HSA and benign splenic mass tissues, our 3-miRNA model (miR-126-5p, miR-502-3p, and miR-452-5p) accurately classified 96% of the cases. This study demonstrates the utility of miRNA models in serum and tissue for screening and diagnosis of HSA in dogs. Future studies include the evaluation of prospective and prediagnosis serum samples.
Entrepreneurial education in the metaverse: Challenges and prospects for business schools
Authors: Maalaoui Adnan , Mejri Issam , Bertrand Gael , Lemaire Severine Le loarne , Kallmuenzer Andreas
Published: February 2025

This paper reexamines the debate on technological disruptive innovation and its tendency to fail, focusing on entrepreneurial education (EE). It explores the emergence of new EE formats, particularly training programs using the metaverse. The research question is: “How are technological disruptive innovations in EE developed and why do most of them fail?”. For that purpose, we mobilize the EE literature as well as the state of the art on innovation processes among business schools, considered to be one of the main vehicles of EE. This state of the art provides a framework for interpreting an ethnographic study on the trajectory of an abandoned EE program initially planned for implementation in the metaverse. Although such initiatives may receive institutional support, they often provoke “crises of stimulation” among faculty (acting as EE innovators), which escalate into “crises of manipulation,” ultimately leading to the project's cessation. The paper contributes to the EE field by examining why metaverse-based EE faces high failure rates and may be difficult to develop within business schools. It also adds to metaverse literature by showing how its applications follow similar failure patterns as other disruptive innovations.
Residual life forecasting and advanced surface damage remanufacturing processes for automotive drive axle shells
Authors: Shen Yechao , Huang Jinlin
Published: February 2025

As a critical component of vehicles, automobile drive axle shells are susceptible to issues such as body cracks, half-shaft casing mating surface wear, and axle head thread damage during service. These problems not only degrade vehicle performance but also compromise driving safety. To address these challenges, this paper proposes a systematic approach combining residual life prediction and surface damage remanufacturing. X-ray diffraction technology is used to analyze the stress state of key areas of the drive axle shell, allowing for the prediction of its remaining life and identification of parts suitable for remanufacturing. For different types of damage, this study investigates surfacing, brush plating, and micro-arc deposition technologies to repair cracks, mating surface wear, and thread damage in the axle housing, respectively. The experimental results demonstrate that this approach significantly enhances the quality and reliability of remanufactured drive axle shells. Specifically, the hardness of the overlay repair layer, prepared using ER50-6 wire, reaches HRC6; the grain size of the special nickel-based brush plating layer is approximately 15 nm; and the magnetic memory gradient change in the remanufactured threads, created by micro-arc deposition, is only 3.4 A/(m−1 mm−1). These outcomes satisfy the practical requirements for hardness, wear resistance, residual stress distribution, and thread joint performance. This paper establishes an efficient, precise, and sustainable repair system for automotive drive axle shells by integrating advanced inspection technologies and diverse remanufacturing processes. The proposed system offers novel solutions and technical support for extending the service life of automotive parts and promoting green manufacturing.
Age assessment and migration control: ‘Child as method’
Authors: Christinaki Artemis
Published: February 2025

In this paper, I critically discuss age assessment and migration control under the analytic category and research tool of ‘child as method’. I start by arguing that for age and its assessment to be explored within the field and practice of humanitarian, migration and refugee studies, it needs to be situated and conceptualised within the pressuring control of migration. Following Burman’s research analytic ‘child as method’, I make a theoretical-analytical argument to discuss how ‘the child’ is understood as a figure or trope within forced migration and displacement, and how ‘childhood’ manifests as a social condition where children are represented and discussed in States’ discourse as victims. In contrast, anyone who employs the legal category of the child is approached by the State and humanitarian sector with suspicion. I conclude by discussing, first, how child, childhood and children as a discourse subjugate refugees by (re)presenting them as children, voiceless and passive. Second, I propose that the figuration of ‘child’ in migration regimes could be strategically understood as an act of resistance.