bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution and Molecular Diversity of Paranoplocephala kalelai (Tenora, Haukisalmi & Henttonen, 1985) Tenora, Murai & Vaucher, 1986 in Voles (Rodentia: Myodes) in Eurasia
Authors: Krivopalov Anton , Vlasenko Pavel , Abramov Sergey , Akimova Lyudmila , Barkhatova Alina , Dokuchaev Nikolai , Gromov Anton , Konyaev Sergey , Lopatina Natalia , Vlasov Egor , Zakharov Eugeny
Published: June 2022

Cestodes Paranoplocephala kalelai, which parasitizes in the small intestine of Myodes voles and is distributed in northern Fennoscandia, was found in six habitats in the Asian part of Russia and eastern Kazakhstan, which indicates a wider distribution of P. kalelai on the continent. Analysis of mtDNA showed that P. kalelai is characterized by significant molecular variability in Eurasia. This study complements the data on the distribution of P. kalelai and provides the first molecular data from the territory of Russia and Kazakhstan. The sequence variability of two mitochondrial genes cox1 and nad1 of P. kalelai was studied in two species of voles: gray red-backed Myodes rufocanus and northern red-backed vole Myodes rutilus. Five haplotype groups in the cox1 and nad1 gene networks were identified, and the existence of two mtDNA lines in P. kalelai outside northern Fennoscandia was confirmed. The geographical distribution of the identified haplotypes suggests that the foothills of the Altai-Sayan mountains and southern West Siberia may serve as a refugium for P. kalelai during repeated glaciations.
Subtle Effects of Experimental Grassland Fragmentation on Density, Species Composition and Functional Dispersion of Gastropods
Authors: Braschler Brigitte , Oggier Peter , Baur Bruno
Published: June 2022

The fragmentation of continuous habitats has significant consequences for species and for the functional diversity of plant and animal communities. Fragmentation effects can be indirect, can occur at different spatial scales and may vary over years. Small fragmentation-related effects may only be detected in standardized, controlled field experiments accounting for the natural variation in environmental conditions and in remnants of habitat. Using a non-invasive trapping approach, we examined the responses of terrestrial gastropods (snails and slugs) to small-scale habitat fragmentation in a controlled experiment conducted in three species-rich, nutrient-poor calcareous grasslands in the Jura Mountains, Switzerland, over four years. We found site-specific differences in species richness, individual density, and species composition. Experimental grassland fragmentation did not significantly affect species richness or density, but affected functional dispersion (a measure of functional diversity) in the final year, indicating that fragmentation-related changes may occur with a time delay. Similarly, experimental fragmentation influenced the mean shell size of the snail assemblage and the proportions of individuals with certain life-history traits or habitat preferences in some years. The observed fragmentation effects were subtle and varied over time, underlining the importance of controlled field experiments.
Prognostic Value of Pathologically Positive Nodal Number in p16-Negative Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma with pN3b Status
Authors: Tsai Ming-Hsien , Lin Yu-Tsai , Chuang Hui-Ching , Huang Tai-Ling , Lu Hui , Chien Chih-Yen , Fang Fu-Min
Published: June 2022

In this study, we aimed to investigate the prognostic value of the number of pathologically positive nodes (pN+) in p16-negative oropharyngeal (OPSCC) and hypopharyngeal (HPSCC) squamous cell carcinoma cases with pN3b status after surgery. We reviewed the clinical and pathological features of 120 newly diagnosed p16-negative OPSCC and HPSCC patients with pN3b status after radical surgery. The primary endpoints were the 5-year overall survival (OS), cancer-specific survival (CSS), and their prognostic factors. We used the Cox proportional hazards model for survival analysis. We generated predictive nomograms that incorporated the clinicopathological factors of OS and CSS. The 5-year OS and CSS rates were 44.1% and 59.1%, respectively. The optimal number of pN+ to predict the 5-year OS and CSS was pN+ = 3. In the Cox model, we observed that pN+ ≥ 3 was a significantly negative predictor of OS (HR: 1.9, 95% CI: 1.1–3.2, p = 0.021) and CSS (HR: 2.3; 95% CI: 1.2–4.6; p = 0.015). After adding the pN+ variable, the c-index of the predictive nomogram incorporating assorted clinicopathological factors increased from 0.66 to 0.689 for OS and from 0.713 to 0.75 for CSS. The results highlight the prognostic value of the pN+ number in p16-negative OPSCC and HPSCC patients with pN3b status.
A 3D Digital Analysis of the Hard Palate Wound Healing after Free Gingival Graft Harvest: A Pilot Study in the Short Term
Authors: Marques Tiago , Ramos Sara , Santos Nuno Bernardo Malta dos , Borges Tiago , Montero Javier , Correia André , Fernandes Gustavo Vicentis de Oliveira
Published: June 2022

Purpose: Within this context, this pilot study aimed to evaluate the healing dynamics process of the hard palate after free gingival graft harvesting in the short term (3 months), utilizing digital imaging technology and tridimensional analysis software. Furthermore, assessing the results found to verify the existence of a relationship between gender or age with tissue loss. Materials and Methods: For connective-tissue harvesting, fifteen patients with gingival recessions type (RT) 1 and RT2 were selected. On the surgery day (before the procedure) and after three months, palatal impressions were taken in all patients, and cast models were done for posterior model scanning. The following variables were analyzed: mean thickness alterations (x¯ TA), maximum thickness loss (MTL), mean maximum thickness loss (x¯ MTL), and volume alterations (VA). A descriptive and bivariate analysis of the data was done. The data were submitted for statistical evaluation and were significant if p < 0.05. Results: Fifteen patients were analyzed, 11 females (73.3%) and four males (26.7%). The patients’ average age was 28 ± 8.52 years (ranging between 16 and 48 years old). The palatal wound region’s mean thickness and volume changes were −0.26 mm (±0.31) and 46.99 mm3 (±47.47 mm3) at three months. There was no statistically significant result correlating age/gender with any variable evaluated. Conclusions: Connective tissue graft harvesting promoted changes with a standard volume and thickness loss of palatal soft tissue. A 3D digital evaluation was a non-invasive method with a reproducible technique for measuring thickness or volume after connective tissue is collected. There was no relationship between age/gender and any variables analyzed.
Exact Solutions to Navier–Stokes Equations Describing a Gradient Nonuniform Unidirectional Vertical Vortex Fluid Flow
Authors: Burmasheva Natalya , Prosviryakov Evgeniy
Published: June 2022

The paper announces a family of exact solutions to Navier–Stokes equations describing gradient inhomogeneous unidirectional fluid motions (nonuniform Poiseuille flows). The structure of the fluid motion equations is such that the incompressibility equation enables us to establish the velocity defect law for nonuniform Poiseuille flow. In this case, the velocity field is dependent on two coordinates and time, and it is an arbitrary-degree polynomial relative to the horizontal (longitudinal) coordinate. The polynomial coefficients depend on the vertical (transverse) coordinate and time. The exact solution under consideration was built using the method of indefinite coefficients and the use of such algebraic operations was for addition and multiplication. As a result, to determine the polynomial coefficients, we derived a system of simplest homogeneous and inhomogeneous parabolic partial equations. The order of integration of the resulting system of equations was recurrent. For a special case of steady flows of a viscous fluid, these equations are ordinary differential equations. The article presents an algorithm for their integration. In this case, all components of the velocity field, vorticity vector, and shear stress field are polynomial functions. In addition, it has been noted that even without taking into account the thermohaline convection (creeping current) all these fields have a rather complex structure.
Maximum Power Point Tracking Control for Non-Gaussian Wind Energy Conversion System by Using Survival Information Potential
Authors: Yin Liping , Lai Lanlan , Zhu Zhengju , Li Tao
Published: June 2022

In this paper, a wind energy conversion system is studied to improve the conversion efficiency and maximize power output. Firstly, a nonlinear state space model is established with respect to shaft current, turbine rotational speed and power output in the wind energy conversion system. As the wind velocity can be descried as a non-Gaussian variable on the system model, the survival information potential is adopted to measure the uncertainty of the stochastic tracking error between the actual wind turbine rotation speed and the reference one. Secondly, to minimize the stochastic tracking error, the control input is obtained by recursively optimizing the performance index function which is constructed with consideration of both survival information potential and control input constraints. To avoid those complex probability formulation, a data driven method is adopted in the process of calculating the survival information potential. Finally, a simulation example is given to illustrate the efficiency of the proposed maximum power point tracking control method. The results demonstrate that by following this method, the actual wind turbine rotation speed can track the reference speed with less time, less overshoot and higher precision, and thus the power output can still be guaranteed under the influence of non-Gaussian wind noises.
Stories That Teachers Tell: Exploring Culturally Responsive Science Teaching
Authors: Wallace Jamie , Howes Elaine , Funk Arthur , Krepski Sean , Pincus Maya , Sylvester Susan , Tsoi Kin , Tully Caity , Sharif Raghida , Swift Samantha
Published: June 2022

In this paper, we explore the stories teachers tell as they study and grapple with culturally responsive education in their science classrooms. This qualitative case study focuses primarily on “Stories from the Field”, a conversational routine at each professional learning group meeting where teachers shared observations, thoughts, and insights about their classroom, instruction, and school settings in the context of culturally responsive education. We found that teachers’ stories from the first year of the group surfaced themes of navigating systemic constraints and supports, connecting through science, and sensemaking and learning from developing and analyzing strategies for culturally responsive science teaching. This helped to shine a light on a critical aspect of our work exploring culturally responsive education and what that might look like in science classrooms through the stories that teachers tell. Our findings suggest that storytelling is a rich, descriptive vehicle for exploration and sensemaking amongst teachers in a professional learning group and an underused resource in studying culturally responsive education, especially in science.
Recursive Least Squares Based Refinement Network for Vehicle Trajectory Prediction
Authors: Li Shengyi , Xue Qifan , Shi Dongfeng , Li Xuanpeng , Zhang Weigong
Published: June 2022

Trajectory prediction of surrounding objects plays a pivotal role in the field of autonomous driving vehicles. In the current rollout process, it suffers from an accumulation of errors, which has a negative impact on prediction accuracy. This paper proposes a parametric-learning recursive least-squares (RLS) method integrated with an encoder–decoder framework for trajectory prediction, named the recursive least-squares-based refinement network (RRN). Through the generation of several anchors in the future trajectory, RRN can capture both local and global motion patterns. We conducted experiments on the prevalent NGSIM and INTERACTION datasets, which contain various scenarios such as highways, intersections and roundabouts. The promising results indicate that RRN could improve the performance of the rollout trajectory prediction effectively.
Managed Evolution of Automotive Software Product Line Architectures: A Systematic Literature Study
Authors: Knieke Christoph , Rausch Andreas , Schindler Mirco , Strasser Arthur , Vogel Martin
Published: June 2022

The rapidly growing number of software-based features in the automotive domain as well as the special requirements in this domain ask for dedicated engineering approaches, models, and processes. Nowadays, software development in the automotive sector is generally developed as product line development, in which major parts of the software are kept adaptable in order to enable reusability of the software in different vehicle variants. In addition, reuse also plays an important role in the development of new vehicle generations in order to reduce development costs. Today, a high number of methods and techniques exist to support the product line driven development of software in the automotive sector. However, these approaches generally consider only partial aspects of development. In this paper, we present an in-depth literature study based on a conceptual model of artifacts and activities for the managed evolution of automotive software product line architectures. We are interested in the coverage of the particular aspects of the conceptual model and, thus, the fields covered in current research and research gaps, respectively. Furthermore, we aim to identify the methods and techniques used to implement automotive software product lines in general, and their usage scope in particular. As a result, this in-depth review reveals that none of the studies represent a holistic approach for the managed evolution of automotive software product lines. In addition, approaches from agile software development are of growing interest in this field.
A Review of Models for Photovoltaic Crack and Hotspot Prediction
Authors: Goudelis Georgios , Lazaridis Pavlos I. , Dhimish Mahmoud
Published: June 2022

The accurate prediction of the performance output of photovoltaic (PV) installations is becoming ever more prominent. Its success can provide a considerable economic benefit, which can be adopted in maintenance, installation, and when calculating levelized cost. However, modelling the long-term performance output of PV modules is quite complex, particularly because multiple factors are involved. This article investigates the available literature relevant to the modelling of PV module performance drop and failure. A particular focus is placed on cracks and hotspots, as these are deemed to be the most influential. Thus, the key aspects affecting the accuracy of performance simulations were identified and the perceived relevant gaps in the literature were outlined. One of the findings demonstrates that microcrack position, orientation, and the severity of a microcrack determines its impact on the PV cell’s performance. Therefore, this aspect needs to be categorized and considered accordingly, for achieving accurate predictions. Additionally, it has been identified that physical modelling of microcracks is currently a considerable challenge that can provide beneficial results if executed appropriately. As a result, suggestions have been made towards achieving this, through the use of methods and software such as XFEM and Griddler.
State Regulation of Energy Transition and Economic Development
Authors: Komarova Anna
Published: June 2022

Government regulation with respect to the reduction of greenhouse gas emissions has been actively developing in the world in the past three decades, mainly in form of carbon taxation and emission trading systems with a carbon price as their basic representation. With more than 50 countries already applying such regulation and many others looking in that direction due to their obligations under the Paris Agreement, the question of suitable carbon price is still open. The aim of this paper is to form groups of countries according to the chosen economic, environmental and regulation factors to facilitate decision-making regarding the formation of energy transition regulation policies. Clustering analysis was carried out to identify countries with similar features in the research area. Five clusters with average carbon price ranging from USD 5.3 to 49.2 per t were obtained. The hypothesis of the study regarding direct connection between the level of economic development and state regulation was partially confirmed. It was revealed that most of the countries with active carbon regulation depend on the external supply of fossil energy sources. The results of the clustering could serve as a benchmark for the countries with similar indicators.
Wind Power Potential in Highlands of the Bolivian Andes: A Numerical Approach
Authors: Mamani Rober , Hendrick Patrick
Published: June 2022

Wind resource assessment is a key factor for the development and implementation of wind farms with the purpose of generating green, eco-friendly and clean electricity. The Bolivian Andes, as a large dry region, represents an important source of renewable energy. However, the altitude and high wind energy resources of the Bolivian Andes require further knowledge and understanding of the wind energy resources. In this study, the GWA have been used to determine the total area available to install wind farms considering the protected areas, roads, cities and transmission lines. In addition, the Weather Research and Forecasting (WRF v3.8.1) model is employed to complement the results of the GWA based on the validation of WRF simulations with measurements from Qollpana wind farm. The main purpose is to estimate the wind power potential along the Bolivian Andes and its variability in time. The wind power simulations have been compared with the power generated by the Qollpana wind farm to verify the WRF’s performance. The wind power potential in the highlands of the Bolivian Andes could reach between 225 (WRF) and 277 (GWA) GW, distributed mainly over the Western and Eastern Cordillera of the Altiplano.
Effect of a Plasma Burner on NOx Reduction and Catalyst Regeneration in a Marine SCR System
Authors: Jang Jaehwan , Ahn Seongyool , Na Sangkyung , Koo Jinhee , Roh Heehwan , Choi Gyungmin
Published: June 2022

The problem of environmental pollution by the combustion of fossil fuels in diesel engines, to which NOx emission is a dominant culprit, has accelerated global environmental pollution and global and local health problems such as lung disease, cancer, and acid rain. Among various De-NOx technologies, SCR (Selective Catalytic Reduction) systems are known to be the most effective technology for actively responding to environmental regulations set by the IMO (International Maritime Organization) in marine diesel applications. The ammonia mixes with the exhaust gas and reacts with the NOx molecules on the catalyst surface to form harmless N2 and H2O. However, since the denitrification efficiency of NOx can be rapidly changed depending on the operating temperature from 250 °C to 350 °C at 0.1% sur contents of the catalyst used in the SCR, a device capable of controlling the exhaust gas temperature is essential for the normal operation of the catalyst. In addition, when the catalyst is exposed to SOx in a low exhaust gas temperature environment, the catalyst is unable to reduce the oxidation reaction of the catalyst, thereby remarkably lowering the De-NOx efficiency. However, if the exhaust gas temperature is set to a high temperature of 360–410 °C, the poisoned catalyst can be regenerated through a reduction process, so that a burner capable of producing a high temperature condition is essential. In this study, a plasma burner system was applied to control the exhaust gas temperature, improving the De-NOx efficiency from the engine and regenerating catalysts from PM (Particulate Matter), SOOT and ABS (ammonia bisulfate), i.e., catalyst poisoning. Through the burner system, the optimum De-NOx performance was experimentally investigated by controlling the temperature to the operating region of the catalyst, and it was shown that the regeneration efficiency in each high temperature (360/410 °C) environment was about 95% or more as compared with the initial performance. From the results of this study, it can be concluded that this technology can positively contribute to the enhancement of catalyst durability and De-NOx performance.
A Novel Intelligent Fan Clutch for Large Hybrid Vehicles
Authors: Shu Ruizhi , Gong Hang , Hu Guanghui , Huang Jin
Published: June 2022

To solve the problems of complex structure, poor reliability, and low intelligence of existing fan clutches for large hybrid vehicles, this paper proposes a new adaptive shape memory alloy intelligent fan clutch for large hybrid vehicle motor cooling. Based on the pure shear shape memory alloy thermodynamic effects, the relationship between shape memory alloy spring recovery force and temperature has been established; based on the shape memory alloy spring thermal drive characteristics and clutch construction dimensions, clutch torque transmission equations have been established. The shape memory alloy fan clutch transmission characteristics were quantitatively analyzed in terms of temperature, torque, rotational speed, and slip rate. The results show that the shape memory alloy fan clutch model based on the finite element method (FEM) and the established transmission model can accurately describe the mechanical characteristics of the shape memory alloy phase change process and the clutch torque transmission characteristics. When the clutch input speed is 3000 rad/min and the temperature is 100 °C, the output torque is 19.04 N·m, the speed is 2877.2 rad/min, and the slip rate is 4.3%. Due to the shape memory effect of shape memory alloy, the clutch can intelligently adjust the fan speed by sensing the ambient temperature. A fan clutch can satisfy the heat dissipation requirement of a large hybrid vehicle’s transmission system under complicated road conditions.
A Novel Ultracapacitor State-of-Charge Fusion Estimation Method for Electric Vehicles Considering Temperature Uncertainty
Authors: Wang Chun , Fang Chaocheng , Tang Aihua , Huang Bo , Zhang Zhigang
Published: June 2022

An ultracapacitor State-of-Charge (SOC) fusion estimation method for electric vehicles under variable temperature environment is proposed in this paper. Firstly, Thevenin model is selected as the ultracapacitor model. Then, genetic algorithm (GA) is adopted to identify the ultracapacitor model parameters at different temperatures (−10 °C, 10 °C, 25 °C and 40 °C). Secondly, a variable temperature model is established by using polynomial fitting the temperatures and parameters, which is applied to promote the ultracapacitor model applicability. Next, the off-line experimental data is iterated by adaptive extended Kalman filter (AEKF) to train the Nonlinear Auto-Regressive Model with Exogenous Inputs (NARX) neural network. Thirdly, the output of the NARX is employed to compensate the AEKF estimation and thereby realize the ultracapacitor SOC fusion estimation. Finally, the variable temperature model and robustness of the proposed SOC fusion estimation method are verified by experiments. The analysis results show that the root mean square error (RMSE) of the variable temperature model is reduced by 90.187% compared with the non-variable temperature model. In addition, the SOC estimation error of the proposed NARX-AEKF fusion estimation method based on the variable temperature model remains within 2.055%. Even when the SOC initial error is 0.150, the NARX-AEKF fusion estimation method can quickly converge to the reference value within 5.000 s.
Review and Prospect of Legal Development in Commercial Nuclear Energy
Authors: Du Wuqing , You Wei , Xu Zhenqing
Published: June 2022

As a major developer of commercial nuclear energy, China saw its developments improve year by year in relevant key indicators such as the number of commercial nuclear facilities, total installed capacity and electricity generation. Accordingly, the legal system of commercial nuclear energy in China has also improved in the past four decades in three phases: Beginning (1985–2002), Growth (2003–2015) and Maturity (2016–now). The legal needs of nuclear energy development, operation, supervision and regulation has been basically met with great focuses on authorities, nuclear safety licensing, disposal of radioactive nuclear wastes and nuclear materials. However, problems still exist, including an inefficient legal system, complicated organic system and inadequate supervision on those regulatory bodies. Looking ahead, efforts should be made in three aspects for safe and healthy development in China’s commercial nuclear industry, specifically, a better relevant legal system, safety management licensing and emergency response to nuclear accidents.
Forest Vulnerability to Climate Change: A Review for Future Research Framework
Authors: Roshani  , Sajjad Haroon , Kumar Pankaj , Masroor Md , Rahaman Md Hibjur , Rehman Sufia , Ahmed Raihan , Sahana Mehebub
Published: June 2022

Climate change has caused vulnerability not only to the forest ecosystem but also to forest-dependent communities. Therefore, its management is essential to increase forest ecosystem services and reduce vulnerability to climate change using an integrated approach. Although many scientific studies examined climate change impact on forest ecosystems, forest vulnerability assessment, including forest sensitivity, adaptability, sustainability and effective management was found to be scant in the existing literature. Through a systematic review from 1990 to 2019, this paper examined forest vulnerability to climate change and its management practices. In this paper, descriptive, mechanism and thematic analyses were carried out to analyze the state of existing research, in order to understand the concept of vulnerability arising from climate change and forest management issues. The present study proposed a framework for integrated forest assessment and management for addressing such issues in future research. The conversion of forest land into other land uses, forest fragmentation, forest disturbance and the effects of climate change on the forest ecosystem are the existing problems. Forest vulnerability, effective adaptation to forest ecosystems and long-term sustainability are priority areas for future research. This study also calls for undertaking researchers at a local scale to involve communities for the effective management of forest ecosystems.
Light Regimes Regulate Leaf and Twigs Traits of Camellia oleifera (Abel) in Pinus massoniana Plantation Understory
Authors: Zhang Yaqin , Guo Qiqiang , Luo Siqiong , Pan Jinwen , Yao Shan , Gao Chao , Guo Youyan , Wang Gang
Published: June 2022

Camellia oleifera (Abel) is an economic tree species and one of the four largest oil plants in the world. The leaf and twig responses and plasticity indices of C. oleifera were investigated under four light regimes in Pinus massoniana understory plantations, namely, 100% light intensity (CK), 75% of CK (HL), 50% of CK (ML), and 30% of CK (LL). The morphological characteristics, biomass allocation, and physiological characteristics of C. oleifera leaves and twigs under different light regimes, as well as their plasticity indexes, were comprehensively evaluated. The results showed that leaf area, and specific leaf area, leaf total carbon, total nitrogen, total phosphorus and chlorophyll contents, and photosynthesis increased, which indicates that plants have the strongest adaptability under HL. No fruit appeared in twigs under LL and ML. The plastic morphological traits were greater than the biomass allocation and physiological traits. The plasticity of palisade/sponge tissue thickness and lower epidermis thickness were the lowest. In conclusion, C. oleifera have differences in sensitivity and regulation mechanism according to their differences in leaf morphological characteristics, biomass allocation physiological indicators, and response to light regimes. C. oleifera plants showed obvious phenotypic inhibition under CK, while they can adjust their strategies for using light energy to maintain their own growth and development under HL. The wide range of light adaptation and strong plasticity of C. oleifera may be two important reasons for its existence in heterogeneous habitats, but it needs at least 75% light regimes to complete its normal growth development and fruit setting. The study provides insights into the optimum light regimes for the improvement of the quality and efficiency of C. oleifera in P. massoniana understory plantations.
Effects of Habitat Filtering on Tree Growth and Mortality across Life Stages in an Old-Growth Temperate Forest
Authors: Han Daxiao , Jin Guangze
Published: June 2022

A demographic (growth and mortality) trade-off plays a central role in the assembly and dynamics of ecological communities and contributes to tree species’ coexistence. On the basis of field investigation data from the 2010 and 2015 censuses, we evaluated the degrees to which the relative growth rate (RGR) and mortality rate (MR) of saplings and large trees were related to habitat filtering for temperate tree species from a 9 ha forest dynamics plot. The results showed that the relationship between RGR and MR was stronger in saplings than that in large trees. In saplings, the total P (TP) and organic C (OC) of the soil had a significantly positive correlation with RGR. In large trees, volumetric water content had a significantly negative correlation with RGR. In saplings, the bulk density and available P had a significantly positive correlation with MR. In large trees, MR showed a significantly negative correlation with aspect and a significantly positive correlation with TP and OC. Principal component analysis showed that species–habitat association status significantly affected the demographic parameters. A linear regression analysis revealed that the process of habitat filtering contributed to the ontogenetic variation that controlled RGR and MR as the community transitioned from saplings to large trees. Moreover, water availability for large trees played a key role in this process in an old-growth temperate forest.
Modification of Artichoke Dietary Fiber by Superfine Grinding and High-Pressure Homogenization and Its Protection against Cadmium Poisoning in Rats
Authors: Zhu Renwei , Xu Tianhui , He Bian , Wang Yayi , Zhang Linwei , Huang Liang
Published: June 2022

This study was carried out to investigate the effects of superfine grinding (SP) and high-pressure homogenization (HPH) on the structural and physicochemical properties of artichoke dietary fiber (ADF), as well as the protective effects against cadmium poisoning in rats. The structural characteristics and physicochemical properties of ADF, HPH-ADF (ADF treated by HPH) and CM-ADF (ADF treated by SP and HPH) were determined, and cadmium chloride (CdCl2) was induced by exposing rats for 7 weeks. The amounts of creatinine and urea; the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum; the quantity of red blood cells, hemoglobin, white blood cells and neutrophil proportion in blood samples; and the activity of glutathione peroxidase (GSH-Px) in liver tissue were analyzed. Hematoxylin-eosin (HE) staining was performed to analyze the tissue structure and pathology of the liver and testis. The results showed that ADF subjected to HPH and SP-HPH exhibited increased content of soluble dietary fiber (SDF) (p < 0.05). HPH and SP-HPH treatments increased oil-holding capacity (OHC), total negative charge (TNC) and heavy metal adsorption capacity (p < 0.05). The CdCl2 intervention led to a significant increase in AST, ALT, creatinine, urea, neutrophil proportion and white blood cell count, as well as a significant decrease in GSH-Px activity, red blood cell count and hemoglobin (HGB) (p < 0.05). In rats fed with ADF, HPH-ADF and CM-ADF significantly reduced creatinine, urea amounts, ALT, AST activity in serum, leukocyte count and the neutrophil ratio in blood and increased GSH-Px activity in the liver, in addition to increasing the erythrocyte count and hemoglobin count in blood (p < 0.05). H&E staining results showed that steatosis in the liver was significantly reduced, whereas testicular tissue edema was improved. These results indicate that ADF exhibited positive activity against cadmium poisoning in rats and that CM-ADF had a better protective effect than ADF and HPH-ADF. ADF has specific potential to be used in health foods or therapeutic drugs, providing a reference for the development and utilization of artichoke waste.
Effects of Weak Acids on the Microbiological, Nutritional and Sensory Quality of Baltic Herring (Clupea harengus membras)
Authors: Logrén Nora , Hiidenhovi Jaakko , Kakko Tanja , Välimaa Anna-Liisa , Mäkinen Sari , Rintala Nanna , Mattila Pirjo , Yang Baoru , Hopia Anu
Published: June 2022

Baltic herring (Clupea harengus membras) pickled in vinegar is a common product in the Nordic countries. Other weak acids are used to cook and preserve fish in other food cultures. The aim of this study was to evaluate the potential of weak acids to produce safe and nutritious pickled fish products with varying sensory properties. The influence of acetic, citric, lactic, malic, and tartaric acids on the preservability and quality of pickled and marinated Baltic herring was studied by measuring microbiological quality, pH, chemical composition, and lipid oxidation and by sensory profiling. Pickling with these acids with pH levels of 3.7–4.2 resulted in pickled Baltic herring products with high microbiological quality. The results of the chemical analysis of the samples indicated that pickling and storage on marinade influenced the chemical composition of fish. The most significant changes in chemical composition were the increase in moisture and decrease in protein content of the samples during storage. Fat content decreased during the storage period in acetic acid and malic acid samples. All tested acids inhibited lipid oxidation for one month, but at three and four month time points, the content of oxidation products increased except in the samples pickled with tartaric acid. The highest oxidation level was observed in the case of citric acid and the lowest with tartaric acid. The results indicate that replacing acetic acid with other weak acids frequently used in the food industry results in pickled and marinated fish products with novel and milder sensory profiles.
An Existence Study for a Multiplied System with p-Laplacian Involving φ-Hilfer Derivatives
Authors: Beddani Hamid , Beddani Moustafa , Cattani Carlo , Hamdi Cherif Mountassir
Published: June 2022

In this paper, we study the existence of solutions for a multiplied system of fractional differential equations with nonlocal integro multi-point boundary conditions by using the p-Laplacian operator and the φ-Hilfer derivatives. The presented results are obtained by the fixed point theorems of Krasnoselskii. An illustrative example is presented at the end to show the applicability of the obtained results. To the best of our knowledge, this is the first time where such a problem is considered.
Gel Polymer Electrolytes with Mixture of Triazolium Ionic Liquids and Propylene Carbonate
Authors: Lewandowska Aneta , Gajewski Piotr , Szcześniak Katarzyna , Marcinkowska Agnieszka
Published: June 2022

This study is focused on the structural influence of 1,2,4-triazolium ionic liquid (IL), that is, the effect of the length of the substituent and the type of substitution (1-methyl-4-alkyl or 1-alkyl-4-methyl) used in the mixture with propylene carbonate (PC) on the properties of thiol–ene polymer ionogels and on the preparation of an ionogel with satisfactory mechanical and conductive properties. PC allows for higher conductivity but also causes electrolyte leakage from the gel. When using triazolium IL (instead of the imidazolium one), because of the stronger interactions between components of the system, the ionogels do not leak. In this study, 1,4-dialkyl-1,2,4-triazolium ILs were successfully synthesized by the alkylation of 1,2,4-triazole. Subsequently, gel polymer electrolytes were obtained by one-pot thiol–ene photopolymerization reactions of tetrafunctional thiols with different chemical structures: pentaerythritol tetra(3-mercaptopropionate) (PETMP) or pentaerythritol tetra(3-mercaptobutyrate) (PETMB) and trifunctional ene (TATT) in the presence of a mixture of 1,4-dialkyl-1,2,4-triazolium IL with PC. Measurements made by electrochemical impedance spectroscopy showed that all ionogels with TATT+PETMB as a polymer matrix presented smaller relative ionic conductivity compared to ionogels containing TATT+PETMP. The puncture resistance and elongation at puncture, measured by the puncture resistance method, were higher for ionogels with poly(TATT+PETMB) than for those with poly(TATT+PETMP). Moreover, ILs containing a methyl group in position N1 of the 1,2,4-triazole ring presented lower puncture resistance than ionogels with ILs containing a methyl group in position N4, especially for shorter alkyl chains. Additionally, the photo-differential scanning calorimetry method was employed to characterize the course of photopolymerization. The compositions and their constituents were characterized by UV and IR spectroscopy.
An Enactive–Ecological Model to Guide Patient-Centered Osteopathic Care
Authors: Cerritelli Francesco , Esteves Jorge E.
Published: June 2022

Osteopaths commonly face complexity and clinical uncertainty in their daily professional practice as primary contact practitioners. In order to effectively deal with complex clinical presentations, osteopaths need to possess well-developed clinical reasoning to understand the individual patient’s lived experience of pain and other symptoms and how their problem impacts their personhood and ability to engage with their world. We have recently proposed (En)active inference as an integrative framework for osteopathic care. The enactivist and active inference frameworks underpin our integrative hypothesis. Here, we present a clinically based interpretation of our integrative hypothesis by considering the ecological niche in which osteopathic care occurs. Active inference enables patients and practitioners to disambiguate each other’s mental states. The patients’ mental states are unobservable and must be inferred based on perceptual cues such as posture, body language, gaze direction and response to touch and hands-on care. A robust therapeutic alliance centred on cooperative communication and shared narratives and the appropriate and effective use of touch and hands-on care enable patients to contextualize their lived experiences. Touch and hands-on care enhance the therapeutic alliance, mental state alignment, and biobehavioural synchrony between patient and practitioner. Therefore, the osteopath–patient dyad provides mental state alignment and opportunities for ecological niche construction. Arguably, this can produce therapeutic experiences which reduce the prominence given to high-level prediction errors—and consequently, the top-down attentional focus on bottom-up sensory prediction errors, thus minimizing free energy. This commentary paper primarily aims to enable osteopaths to critically consider the value of this proposed framework in appreciating the complexities of delivering person-centred care.
Histological Kidney Re-Evaluation after Daratumumab Monotherapy for AL Amyloidosis
Authors: Fenoglio Roberta , Rabajoli Gianluca , Barreca Antonella , De Simone Emanuele , Sciascia Savino , Roccatello Dario
Published: June 2022

Background: AL amyloidosis is a systemic disorder characterized by extracellular deposition of characteristic fibrils that results in progressive multi-organ failure and premature death. Recently daratumumab has been demonstrating higher hematological and organ response rates when compared to the standard of care. We hereby report our long-term experience on the effects of daratumumab given alone on the deposition of amyloid as evaluated in repeat renal biopsy. Results: Six patients were enrolled. All patients had proteinuria that was associated with renal function impairment in four. After therapy with daratumumab, four patients achieved complete hematological response and two had partial hematological response at the end of treatment. With regard to renal response, four out of six patients achieved an organ response; one patient had fluctuating proteinuria levels and did not meet the needed criteria at the end of the treatment and the last patient, who was already in dialysis at the time of therapy initiation, remained on dialysis despite complete hematological and cardiac responses. A significant decrease in 24-h proteinuria from 7.9 g/24 h to 1.1 (p < 0.005) with stabilization or improvement of sCr (from 1.5 mg/dL to 1.2 mg/dL; p = 0.34) were observed. All patients underwent a repeat biopsy after 24 administrations of daratumumab. In five patients, the repeat biopsy showed unchanged features; while in one it showed an improvement. Conclusions: Our data, based on real life experience, show that daratumumab monotherapy can be an effective therapeutic option. It is capable not only of achieving a substantial rate of renal improvement in pre-treated and naïve patients, but also of limiting renal deposition
Effect of Treated Wastewater Irrigation on the Accumulation and Transfer of Heavy Metals in Lemon Trees Cultivated in Arid Environment
Authors: Albdaiwi Randa N. , Al-Hawadi Jehad S. , Al-Rawashdeh Ziad B. , Al-Habahbeh Khaled A. , Ayad Jamal Y. , Al-Sayaydeh Rabea S.
Published: June 2022

The Middle East is considered as one of the driest regions of the world and the use of municipal-treated wastewater (TWW) for agricultural purposes is needed. The aim of this study was to evaluate the effect of continuous irrigation of TWW in lemon orchards on the accumulation of heavy metals (HMs) in the soil, as well as their uptake and translocation to aerial parts of the trees. For this purpose, two lemon orchards were selected to be irrigated from two different water sources: TWW from a tertiary treatment plant and freshwater (SW) from Moses springs in Jordan. Continuous irrigation with TWW resulted in higher concentrations of nutrients and HM accumulation in the soil as compared to SW. However, HM accumulation in the soil was found to be within the acceptable range according to the standards of the WHO. On the contrary, the continuous irrigation with TWW resulted in the accumulation of HMs in plant parts when compared to SW irrigation; the fruits were clearly affected by the accumulation of high levels of Cd and Pb that exceed the maximum limits for the presence of HMs in plant tissues. The irrigation of lemon trees with TWW had a significant effect on the bioaccumulation factor and translocation factors (TF) of HMs into different lemon tree parts. Heavy metal accumulation coincided with high translocation rates to different tree parts, and this is considered to be a main challenge for long-term irrigation with TWW in arid environments.
A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
Authors: Leonso Ana-Alicia , Brown Kyle , Prol Raquel , Rawat Saumya , Khunger Arjun , Bromberg Romina
Published: June 2022

Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months after a successful inpatient treatment of COVID-19. A 74-year-old female from the Philippines presented with a new left mid-lung infiltrate with worsening shortness of breath and lethargy for one week prior to admission. The clinical course of the patient deteriorated despite broad-spectrum antibiotics, diuretics, and high-dose steroid therapy requiring intubation and mechanical ventilation. Her sputum culture yielded the microbiological diagnosis of TB. Anti-tubercular medications were started and the patient had a favorable clinical outcome. Our case demonstrates that immunosuppression secondary to COVID-19 and its treatments may promote the development of an active TB infection from a latent infection. It is important to be aware of this potential increase in risk during and after a COVID-19 treatment. This is especially important in high-risk populations to ensure an early diagnosis and prompt management as well as to reduce transmission.
Combined Use of Transcutaneous Electrical Nerve Stimulation and Short Foot Exercise Improves Navicular Height, Muscle Size, Function Mobility, and Risk of Falls in Healthy Older Adults
Authors: Namsawang Juntip , Muanjai Pornpimol
Published: June 2022

Electrical stimulation is an established method that is used to improve muscle strength. The present study compared changes in the navicular drop test (NDT), muscle size, the five times sit to stand (5TSTS) test, the timed up and go (TUG) test, and the risk of falls in response to transcutaneous electrical nerve stimulation (TENS) plus short foot exercise (SFE) and SFE alone in 68 healthy elderly participants aged 65–75 years. Participants were randomly assigned to two groups: TENS plus SFE and SFE alone (with sham TENS). Measurements of NDT, muscle size, 5TSTS, TUG, and risk of falls were made before and after 4 weeks of training. The NDT was significantly improved by a median of 0.31 mm in the TENS plus SFE group and 0.64 mm in the SFE alone group (p < 0.001). Similarly, there was a significant improvement in Falls Efficacy Scale International (FES-I), 5TSTS, and TUG for both groups (p < 0.001). The abductor hallucis muscle size increased by 0.23 cm2 in the TENS plus SFE group and 0.26 cm2 in the SFE alone group (p < 0.001). There were no significant differences between the two groups for any variables (p > 0.05) except TUG, which showed a greater improvement in the TENS plus SFE group (p = 0.008). Our findings demonstrated that TENS plus SFE and SFE alone improved intrinsic foot muscle size. However, TENS plus SFE tended to improve NDT more than SFE alone, particularly in cases of severe muscle weakness. Thus, the combined use of TENS plus SFE could be recommended for muscle strengthening and balance programs for fall prevention in older adults.
The Transition of Cities towards Innovations in Mobility: Searching for a Global Perspective
Authors: Medina-Molina Cayetano , Rey-Tienda María de la Sierra , Suárez-Redondo Eva María
Published: June 2022

The growing concentration of the population in urban areas presents great challenges for sustainability. Within this process, mobility emerges as one of the main generators of externalities that hinder the achievement of the Sustainable Development Goals. The transition of cities towards innovations in sustainable mobility requires progress in different dimensions, whose interaction requires research. Likewise, it is necessary to establish whether the experiences developed between cities with different contexts can be extrapolated. Therefore, the purpose of this study was to identify how the conditions that determine a city’s readiness to implement urban mobility innovations could be combined. For this, qualitative comparative analysis was applied to a model developed using the multi-level perspective, analyzing 60 cities from different geographical areas and with a different gross domestic product per capita. The R package Set Methods was used. The explanation of the readiness of cities to implement mobility innovations is different to the explanation of the readiness negation. While readiness is explained by two solutions, in which only regime elements appear, the negation of readiness is explained by five possible solutions, showing the interaction between the landscape and regimen elements and enacting the negation of innovations as a necessary condition. The cluster analysis shows us that the results can be extrapolated between cities with different contexts.