bluuebunny/crossref_metadata_2025 huggingface dataset:
New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies
Authors: Rajamuthy Vikneswaran , Eltayeb Naser Eltaher , Subramaniam Ramesh , Rosiyah Yahya
Published: March 2016

The reaction of the thiosemicarbazones (CH2)4CNN(H)C(S)NHR (R = H, Me) with zinc(II) acetate in methanolic solution proceeds readily under mild conditions to form stable mononuclear complexes Zn[(CH2)4CNNC(S)NHR]2. DNA interaction studies show that the zinc(II) complexes bind to DNA via groove mode and exhibit efficient DNA cleavage activity in the presence of hydrogen peroxide. Also, the complexes display a binding affinity to bovine serum albumin protein with KBSA values of ca 105 M−1. Topoisomerase catalytic inhibition studies suggest that both complexes are efficient topoisomerase‐I impeders. Furthermore, the anti‐proliferative effects of the two complexes on five human tumor cell lines (Caki‐2, MCF‐7, CaSki, NCI‐H322M and Co‐115) indicate that both complexes have the potential to act as effective anticancer drugs. Copyright © 2016 John Wiley & Sons, Ltd.
Reintroduction of a dioecious aquatic macrophyte (Stratiotes aloides L.) regionally extinct in the wild. Interesting answers from genetics
Authors: Orsenigo Simone , Gentili Rodolfo , Smolders Alfons J. P. , Efremov Andrey , Rossi Graziano , Ardenghi Nicola M. G. , Citterio Sandra , Abeli Thomas
Published: March 2016

The reintroduction of a plant species regionally extinct in the wild poses a stimulating conservation challenge. If the species is dioecious and the ex situ preserved population is only of one sex, the challenge is even more difficult. To assess whether the female population of Stratiotes aloides originally studied requires a reinforcement to increase its genetic variation, and to determine from which source male individuals should be taken to re‐establish a viable population, the genetic structure of nine different accessions of S. aloides across Europe and Asia were analysed – six native populations and the last three Italian populations, preserved ex situ.

Amplified fragment length polymorphism (AFLP) fingerprinting of 190 individuals from these populations was performed using six primer combinations and chromosome counts.

AFLP markers revealed medium to high values of genetic diversity at the population level, unexpectedly including residual ex situ accessions. Neighbour‐joining tree, PCoA and STRUCTURE analyses indicate the presence of three genetic patterns identifiable in the central‐western, central and eastern Europe–Asian populations. Chromosome counts revealed the presence of diploid (2n = 24) and tetraploid (2n = 48) populations.

Similarity between populations belonging to different hydrographical basins, and differences between neighbouring populations could be explained through long‐distance bird‐mediated dispersal events. Genetic analysis showed that reinforcement with female individuals from other European populations to increase the genetic diversity of the Italian female population is not necessary. Surprisingly, the geographically closest male population (Bavaria) to the Po basin is not the best option for male reintroduction. Instead, male individuals should be reintroduced from the Rhine basin (Netherlands) and eastern part of the Danube basin (Romania).

Copyright © 2016 John Wiley & Sons, Ltd.
Ring Expansion via Cleavage of Benzylic C−C Bonds Enabling Direct Synthesis of Medium Ring‐Fused Benzocarbocycles
Authors: Rao Bin , Tang Jinghua , Wei Yu , Zeng Xiaoming
Published: March 2016

A fluoride‐anion‐induced, regioselective ring expansion of benzocyclic ketones and α‐aryl cycloketones has been developed via insertion of arynes into unactivated benzylic C−C bonds. This reaction provides a straightforward, transition‐metal‐free avenue to prepare medium ring‐fused benzocarbocycles by creating “noble” seven‐, eight‐, and nine‐membered rings. Applications of this method in the creation of medium‐sized exocyclic and inner benzocyclic olefins, nine‐membered lactones, and lactams are described.
Aging and autism spectrum disorder: Evidence from the broad autism phenotype
Authors: Wallace Gregory L. , Budgett Jessica , Charlton Rebecca A.
Published: March 2016

This study investigated for the first time the broad autism phenotype (BAP) in the context of older adulthood and its associations with real‐world executive function, social support, and both depression and anxiety symptomatology. Based on self‐ratings of autistic traits, 66 older adults (60+ years old, range = 61–88) were split into BAP (n = 20) and control (n = 46) groups. Individuals in the BAP group, even after controlling for age, education level, sex, and health problems, exhibited more real‐world executive function problems in multiple domains, reported lower levels of social support, and self‐rated increased depression and anxiety symptomatology compared to the control group. Regression analysis revealed that level of social support was the strongest predictor of BAP traits across both groups, although real‐world executive function problems and depression symptomatology were also significant predictors. Moreover, when predicting anxiety and depression symptomatology, BAP traits were the strongest predictors above and beyond the effects of demographic factors, real‐world executive function problems, and social support levels. These findings suggest that the BAP in older adulthood imparts additional risks to areas of functioning that are known to be crucial to aging‐related outcomes in the context of typical development. These results might in turn inform aging in autism spectrum disorder, which has been largely unexplored to date. Autism Res 2016, 9: 1294–1303. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
Enzymes in therapy of biofilm‐related oral diseases
Authors: Pleszczyńska Małgorzata , Wiater Adrian , Bachanek Teresa , Szczodrak Janusz
Published: March 2016

Biofilm‐related infections of the oral cavity, including dental caries and periodontitis, represent the most prevalent health problems. For years, the treatment thereof was largely based on antibacterial chemical agents. Recently, however, there has been growing interest in the application of more preventive and minimally invasive biotechnological methods. This review focuses on the potential applications of enzymes in the treatment and prevention of oral diseases. Dental plaque is a microbial community that develops on the tooth surface, embedded in a matrix of extracellular polymeric substances of bacterial and host origin. Both cariogenic microorganisms and the key components of oral biofilm matrix may be the targets of the enzymes. Oxidative salivary enzymes inhibit or limit the growth of oral pathogens, thereby supporting the natural host defense system; polysaccharide hydrolases (mutanases and dextranases) degrade important carbohydrate components of the biofilm matrix, whereas proteases disrupt bacterial adhesion to oral surfaces or affect cell–cell interactions. The efficiency of the enzymes in in vitro and in vivo studies, advantages and limitations, as well as future perspectives for improving the enzymatic strategy are discussed.
Porcine circovirus type 2 protective epitope densely carried by chimeric papaya ringspot virus–like particles expressed in Escherichia coli as a cost‐effective vaccine manufacture alternative
Authors: Aguilera Brenda Eugenia , Chávez‐Calvillo Gabriela , Elizondo‐Quiroga Darwin , Jimenez‐García Mónica Noemí , Carrillo‐Tripp Mauricio , Silva‐Rosales Laura , Hernández‐Gutiérrez Rodolfo , Gutiérrez‐Ortega Abel
Published: March 2016

Porcine circovirus type 2 (PCV2) still represents a major problem to the swine industry worldwide, causing high mortality rates in infected animals. Virus‐like particles (VLPs) have gained attention for vaccine development, serving both as scaffolds for epitope expression and immune response enhancers. The commercial subunit vaccines against PCV2 consist of VLPs formed by the self‐assembly of PCV2 capsid protein (CP) expressed in the baculovirus vector system. In this work, a PCV2 protective epitope was inserted into three different regions of papaya ringspot virus (PRSV) CP, namely, the N‐ and C‐termini and a predicted antigenic region located near the N‐terminus. Wild‐type and chimeric CPs were modeled in silico, expressed in Escherichia coli, purified, and visualized by transmission electron microscopy. This is the first report that shows the formation of chimeric VLPs using PRSV as epitope‐presentation scaffold. Moreover, it was found that PCV2 epitope localization strongly influences VLP length. Also, the estimated yields of the chimeric VLPs at a small‐scale level ranged between 65 and 80 mg/L of culture medium. Finally, the three chimeric VLPs induced high levels of immunoglobulin G against the PCV2 epitope in immunized BALB/c mice, suggesting that these chimeric VLPs can be used for swine immunoprophylaxis against PCV2.
Mechanism of pancreatic and liver malformations in human fetuses with short‐rib polydactyly syndrome
Authors: Loo Christine K.C. , Pereira Tamara N. , Ramsing Mette , Vogel Ida , Petersen Olav B. , Ramm Grant A.
Published: March 2016

Background

The short‐rib polydactyly (SRP) syndromes are rare skeletal dysplasias caused by abnormalities in primary cilia, sometimes associated with visceral malformations.

Methods

The pathogenesis of ductal plate malformation (DPM) varies in different syndromes and has not been investigated in SRP. We have studied liver development in five SRP fetuses and pancreatic development in one SRP fetus, with genetically confirmed mutations in cilia related genes, with and without DPMs, using the immunoperoxidase technique, and compared these to other syndromes with DPM.

Results

Acetylated tubulin expression was abnormal in DPM in SRP, Meckel syndrome, and autosomal recessive polycystic kidney disease (ARPKD), confirming ciliary anomalies. SDF‐1 was abnormally expressed in SRP and two of three cases of autosomal dominant polycystic kidney disease (ADPKD) but not ARPKD or Meckel. Increased density of quiescent hepatic stellate cells was seen in SRP, Meckel, one of three cases of ARPKD, and two of three cases of ADPKD with aberrant hepatocyte expression of keratin 19 in SRP and ADPKD. Immunophenotypic abnormalities were present even in fetal liver without fully developed DPMs. The SRP case with DPM and pancreatic malformations showed abnormalities in the pancreatic head (influenced by mesenchyme from the septum transversum, similar to liver) but not pancreatic body (influenced by mesenchyme adjacent to the notochord).

Conclusion

In SRP, there are differentiation defects of hepatocytes, cholangiocytes, and liver mesenchyme and, in rare cases, pancreatic mesenchymal anomalies. The morphological changes were subtle in early gestation but immunophenotypic abnormalities were present. Mesenchymal–epithelial interactions may contribute to the malformations. Birth Defects Research (Part A) 106:549–562, 2016. © 2016 Wiley Periodicals, Inc.
Drone based measurement system for radiofrequency exposure assessment
Authors: Joseph Wout , Aerts Sam , Vandenbossche Matthias , Thielens Arno , Martens Luc
Published: March 2016

For the first time, a method to assess radiofrequency (RF) electromagnetic field (EMF) exposure of the general public in real environments with a true free‐space antenna system is presented. Using lightweight electronics and multiple antennas placed on a drone, it is possible to perform exposure measurements. This technique will enable researchers to measure three‐dimensional RF‐EMF exposure patterns accurately in the future and at locations currently difficult to access. A measurement procedure and appropriate measurement settings have been developed. As an application, outdoor measurements are performed as a function of height up to 60 m for Global System for Mobile Communications (GSM) 900 MHz base station exposure. Bioelectromagnetics. 37:195–199, 2016. © 2016 Wiley Periodicals, Inc.
Disturbed sleep in individuals with idiopathic environmental intolerance attributed to electromagnetic fields (IEI‐EMF): Melatonin assessment as a biological marker
Authors: Andrianome Soafara , Hugueville Laurent , de Seze René , Hanot‐Roy Maïté , Blazy Kelly , Gamez Christelle , Selmaoui Brahim
Published: March 2016

Individuals who suffer from idiopathic environmental intolerance attributed to electromagnetic fields (IEI‐EMF) complain of a variety of adverse health effects. Troubled sleep remains a recurrent and common symptom in IEI‐EMF individuals. Melatonin, a circadian hormone, plays a major role in the sleep process. In this study, we compared levels of melatonin between a sensitive group (IEI‐EMF,n = 30) and a non‐sensitive control group (non IEI‐EMF,n = 25) without exposure to electromagnetic sources. Three questionnaires were used to evaluate the subjective quality and sleep quantity: the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index and the Spiegel Sleep Inventory. Melatonin was quantified in saliva and its major metabolite 6‐sulfatoxymelatonin (aMT6s) in urine. Melatonin levels were compared by a two‐way analysis of variance at various times between the control and IEI‐EMF group. Despite significantly different sleep scores between the two groups, with a lower score in the IEI‐EMF group (P < 0.001), no statistical difference was found between the two groups for saliva melatonin (P > 0.05) and urine aMT6s (P > 0.05). Bioelectromagnetics. 37:175–182, 2016. © 2016 Wiley Periodicals, Inc.
Effects of Substituents on NMR Chemical Shifts and Mass Fragmentation Patterns of 1‐Aryl‐3‐phenylpropanes
Authors: Jeong Eun Jeong , Lee In‐Sook Han
Published: March 2016

The
1H and
13C chemical shifts and the mass spectral fragmentation patterns of 1‐aryl‐3‐phenylpropanes with m‐ or p‐substituents (H, NO2
, Br, Cl, OCH3
, CH3
) were studied. The electronic effects of the substituents seemed to be transmitted by the through‐space as well as by a through‐bond mechanism, resulting in an inverse correlation in the plot of the chemical shift values of i‐C vs. the Hammett σ values. The mass spectra showed the substituted benzyl fragments as the base peaks when the substituents were electron donating, whereas the benzyl fragment was observed as the base peaks with the electron‐withdrawing substituents.
Electrochemically Inducible Surfaces for Patterning Two Distinct Molecules
Authors: Choi Inseong , Yeo Woon‐Seok
Published: March 2016

Herein, we report on a new multicomponent patterning method based on electrochemically inducible self‐assembled monolayers on gold. Two different masked functional groups on monolayers are activated to give amine and acetylene moieties through electrochemical activations at negative potential and positive potential, respectively. The resulting amine and acetylene groups are further used as chemical handles for incorporation of ligand molecules via well‐known chemoselective conjugation reactions such as amine‐specific conjugation chemistry and click reaction. The chemical conversions of masked functional groups to amine and acetylene groups were characterized by cyclic voltammetry. We demonstrated the orthogonal immobilization of two fluorescent dyes on the patterned surface along the patterned features. Our strategy can provide a useful platform technology for the preparation of multicomponent ligand‐patterned substrates with various advantages such as chemical flexibility, mild reaction conditions, and high yields of two orthogonal chemical reactions of amine‐specific conjugation and click reaction.
I decide, therefore I am (relevant!): A project‐based learning experience in linear algebra
Authors: Izquierdo Joaquín , Benítez Julio , Berenguer Antonio , Lago‐Alonso Concepción
Published: March 2016

We present a project‐based learning experience in the context of linear algebra developed for the recently launched double major in business administration and management/engineering of technology and telecommunication services at the universitat politècnica de valència 2014–15. Decision‐making is used to motivate students towards applying, understanding, and appreciating linear algebra in a diversity of projects. this experience introduces students to the analytic hierarchy process (AHP), a multi‐attribute, decision‐making technique that is rooted in linear algebra. Through a simulation scenario, each team of students develops a project about any real‐world problem consisting of a decision‐making process in the presence of multiple intangibles. At the same time, the algebraic fundamentals that make the process valid and consistent are clarified. The students showed great interest in the experience; and the results obtained confirmed that the activities helped them understand several complex concepts related to linear algebra, and fostered a significant interest in a subject traditionally considered frighteningly abstract. Finally, the students appreciated the stimulating insights provided by linear algebra that are crucial in decision‐making. This multi‐disciplinary experience enables the evaluation of several cross skills and competencies such as critical thinking and ethical leadership. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:481–492, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21725
Development of a new android application to remotely control a micro‐cogeneration system as e‐learning tool
Authors: Crespo Bárbara , Rey Guillermo , Míguez Carla , Míguez Tabarés José Luis , De Lara José
Published: March 2016

The increasing use of smartphone technology in people's daily lives and its continuous development lead to the inevitable use of mobile applications because of their easy access anytime and anywhere. In this study, a new Android application for smartphones is developed and presented for the remote control of a micro‐cogeneration system from a mobile device without the need to be near the system. The mobile application consists of five different windows through which real‐time data on the most important variables of the system can be observed at any time. Additionally, the application allows the user to select the system's desired operating mode among a total of five possibilities. Alarms and warnings are also shown along with the detailed status of the main variables of the groups forming the system. Moreover, the application can graphically show the progression of variables at any time, and a history of the changes to the system is available. An experimental practice based on the “use of current mobile applications” for a subject of the Master of Thermal Engineering is proposed as a pedagogical method that involves the procedure “learning by doing,” in which students can realize the great advantages of using these technologies. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:497–507, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21726
Veil as Stigma: Exploring the Role of Representations in Muslim Women's Management of Threatened Social Identity
Authors: Chapman Madeleine
Published: March 2016

This study extends research on the relations between social representations and social identities through an exploration of how Muslim women manage the stigma of veiling. Based on analysis of individual and group interviews among Muslim women in Denmark and the UK, the study highlights the dialectical nature of social identity as constructed through and against others' representations of social groups and the norms of valuing they impose. It shows how, for the women here, the reinforcement of a shared sense of Muslim identity goes together with re‐evaluation of aspects of that identity, principally in response to representations of the veil that deny Muslim women agency and cast them as oppressed. It shows how norms of gender and agency are in this process variously resisted and affirmed, resulting in the reframing of gendered religious values. Theoretically, the study argues that an account of the role of representations in the construction of identity challenges the inter‐group framework of existing approaches to threatened social identity and sheds light on intersectional dynamics of identity. Copyright © 2016 John Wiley & Sons, Ltd.
Weigh pros, cons of moving sports medicine out from under the athletics department's umbrella
Authors: McCarthy Claudine
Published: March 2016

After several high‐profile academic fraud scandals, schools began moving academic support services for their student‐athletes out from under the athletics department's umbrella.
Build a better athletics department by engaging creative strengths of staff members
Authors: Sutton Halley
Published: March 2016

CHICAGO — As an athletics administrator, you constantly work on projects with teams. Without the proper understanding of the different creative styles that the other staff members on your team possess, you cannot tap the full potential of your team or manage the complicated dynamics that come from many different types of creative styles. In a session led by June Hanley during the annual convention for the Society for College and University Planning, participants were led through an exercise based on The Five Faces of Genius by Annette Moser‐Wellman and given instructions on how to create a well‐rounded team that takes advantage of different creative styles.
Did a university breach coach's contract with reassignment to new position?
Authors: Gelpi Aileen
Published: March 2016

James Fleming signed a written contract in 2010 to be the defensive coordinator of the Kent State University football team. His term of employment was supposed to last through June 2012.
Develop plans for increasing success in athletics, academics and beyond
Authors: McCarthy Claudine
Published: March 2016

Ten years ago, Michael McBroom made an ambitious and strategic decision to no longer limit expectations for success to only three or four sports.
Successful use of nicotine replacement therapy to quit e‐cigarettes: lack of treatment protocol highlights need for guidelines
Authors: Silver Barbara , Ripley‐Moffitt Carol , Greyber Jennifer , Goldstein Adam O.
Published: March 2016

Key Clinical Message

Although use of electronic nicotine delivery system devices, such as e‐cigarettes and vapor pens, is on the rise, no treatment protocols exist to help such users quit. We report the case of a 24‐year‐old patient in a tobacco treatment program who successfully quit e‐cigarette use by using nicotine replacement therapy.
Giant neck swelling
Authors: De Utpal , Nandi Mintu Mohon , Kabiraj Pranoy
Published: March 2016

Key clinical message

The most common benign salivary gland tumor is pleomorphic adenoma. They can attain giant proportions and weigh several kilograms. They can cause facial disfigurement and, if untreated, could lead malignant transformation. This image depicts a 7.5 kg pleomorphic adenoma of right submandibular gland with malignant change in a 55‐year‐old male.
Seventy‐year‐old patient survives a giant apical LV pseudoaneurysm for 8 years
Authors: Razik Nady A. , Taha Salma , ElMaghraby Khaled , Demitry Salwa
Published: March 2016

Key clinical message

The risk of rupture of LV pseudaneurysm is still not well understood, and ischemic cardiomyopathy with heart failure is a common consequence. Simple investigations like chest X‐ray can give clue to such a serious diagnosis.
A case of pulmonary alveolar microlithiasis associated with a homozygous 195 kb deletion encompassing the entire SLC34A2 gene
Authors: Stokman Lara , Nossent Esther J. , Grunberg Katrien , Meijboom Lilian , Yakicier Mustafa C. , Voorhoeve Els , Houweling Arjan C.
Published: March 2016

Key Clinical Message

With around 500 cases published worldwide, pulmonary alveolar microlithiasis is a rare disorder with an autosomal recessive pattern of inheritance. We show for the first time that homozygous deletions encompassing the entire SCL34A2 can be associated with this rare genetic pulmonary disease.
Carbon Nanotube–Ruthenium Hybrids for the Partial Reduction of 2‐Nitrochalcones: Easy Access to Quinoline N‐Oxides
Authors: Basu Pallabita , Prakash Praveen , Gravel Edmond , Shah Nimesh , Bera Kalisankar , Doris Eric , Namboothiri Irishi N. N.
Published: March 2016

A ruthenium–carbon nanotube nanohybrid was employed as a catalyst in the tandem transformation of nitrochalcones into quinoline N‐oxides. Partial reduction of the nitro group to a hydroxylamine, followed by in situ intramolecular condensation to the carbonyl afforded the quinoline‐N‐oxides in satisfactory to good yields. Reduction of the nitro group was selective and independent of changes in the reaction conditions. Highlights of this method include a very low catalyst loading relative to that required for conventional methods for the synthesis of quinoline N‐oxides and mild reaction conditions.
Scalable Synthesis of Palladium Icosahedra in Plug Reactors for the Production of Oxygen Reduction Reaction Catalysts
Authors: Wang Helan , Niu Guangda , Zhou Ming , Wang Xue , Park Jinho , Bao Shixiong , Chi Miaofang , Cai Zaisheng , Xia Younan
Published: March 2016

We have synthesized Pd icosahedra with uniform, controllable sizes in plug reactors separated by air. The oxygen contained in the air segments not only contributed to the generation of a reductant from diethylene glycol in situ, but also oxidized elemental Pd back to the ionic form by oxidative etching and thus slowed down the reduction kinetics. Compared to droplet reactors involving silicone oil or fluorocarbon, the use of air as a carrier phase could reduce the production cost by avoiding additional procedures for the separation of products from the oil. The average diameters of the Pd icosahedra could be readily controlled in the range of 12–20 nm. The Pd icosahedra were further employed as seeds for the production of Pd@Pt2–3L core‐shell icosahedra, which could serve as a catalyst toward the oxygen reduction reaction with greatly enhanced activity. We believe that the plug reactors could be extended to other types of noble‐metal nanocrystals for their scale‐up production.
Agglomeration Mechanism of Nanoparticles by Adding Coarse Fluid Catalytic Cracking Particles
Authors: Wang Jian , Xu Bao , Zhou Tao , Liang Xizhen
Published: March 2016

The agglomeration mechanism of SiO2, TiO2, and ZnO nanoparticles by adding coarse fluid catalytic cracking (FCC) particles is studied. The core‐shell structure of agglomerates is revealed on the basis of experimental analyses. Nanoparticles can be fluidized by forming agglomerates of the core‐shell structure with coarse FCC particles. The porosity of core‐shell structure agglomerates and the average roundness value were found to be distinctly lower than those of pure nanoparticle agglomerates. In addition, the cohesion of the core‐shell structure agglomerates is far less than that of the agglomerates formed by pure nanoparticles. Due to the smaller porosity, irregular shape, and relatively low cohesion, the fluidization behavior of core‐shell structure agglomerates is better than that of pure nanoparticle agglomerates.
Recovery of Oil, Erucic Acid, and Phenolic Compounds from Rapeseed and Rocket Seeds
Authors: Koubaa Mohamed , Mhemdi Houcine , Sanlaville Quentin , Vorobiev Eugène
Published: March 2016

Erucic acid‐enriched oil, sought for industrial purposes, from rapeseed (agronomic plant) and rocket seeds (non‐agronomic plant) was extracted by three different processes: supercritical CO2, mechanical expression, and hexane extraction. Oil extraction yields were determined and the extracted oils were characterized for their fatty acid and phenolic compound compositions. Higher oil yields were achieved using hexane compared to mechanical expression and supercritical CO2 extractions. Fatty acid analysis indicated a higher content of erucic acid in rapeseed oil than in rocket oil. In addition, supercritical CO2 extraction allowed better recovery of phenolic compounds with high antioxidant activities. The most prominent identified polyphenols were vanillin, sinapic acid, syringic acid, and apigenin.
Cobalt Modification for Improving Potassium Resistance of Mn/Ce‐ZrO2 in Selective Catalytic Reduction
Authors: Xiaopeng Zhang , Yuezong Cui , Zhuofeng Li , Xuerong Zhou , Gaohong He
Published: March 2016

The three catalysts Mn/Ce‐ZrO2, MnCo/Ce‐ZrO2, and Mn/Co‐Ce‐ZrO2 were applied to remove NO in simulated flue gas. Their selective catalytic reduction (SCR) activity and potassium resistance were studied. Catalysts with Co as a modifier of the support exhibited the best SCR activity. The catalyst Mn/Co‐Ce‐ZrO2 had a larger surface area, higher dispersion of active components, larger amount of surface acid, and better redox characteristics than the other two catalysts, leading to a better SCR activity. X‐ray photoelectron spectroscopy results proved the higher surface Mn4+ concentration of K0.3Mn/Co‐Ce‐ZrO2. Pyridine adsorption analysis suggested that there was still a large amount of Lewis acid in Mn/Co‐Ce‐ZrO2 even after potassium poisoning, demonstrating the higher resistance of this catalyst to potassium. Mn/Co‐Ce‐ZrO2 with potassium addition had a relatively stable SCR activity in the presence of H2O and SO2.
Acceleration of Anti‐Markovnikov Hydroamination in the Synthesis of an Active Pharmaceutical Ingredient
Authors: Mitic Aleksandar , Skovby Tommy , Dam‐Johansen Kim , Gernaey Krist V.
Published: March 2016

Slow chemical reactions are a big challenge in the modern pharmaceutical industry. Their accelerations together with the introduction of continuous manufacturing modes are major drivers for future development. One example reaction is hydroamination, a reaction between unsaturated hydrocarbons and amines. Such a reaction type is the main focus of this work. More precisely, the anti‐Markovnikov hydroamination reaction between cis/trans 9H‐thioxanthene‐2‐chloro‐9‐(2‐propenylidene)‐(9CI) and 1‐(2‐hydroxyethyl)piperazine (HEP) is investigated in detail. It has been traditionally performed in toluene with a huge excess of HEP and reaction times of up to 24 h. Acceleration of the reaction from 24 down to 4 h is achieved by switching from batch operation mode in toluene to either solvent‐free batch mode or microwave‐assisted hydroamination with tetrahydrofuran as a solvent.
Comment on “Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum”
Authors: Davoli Paolo , Floriani Marco , Assisi Francesca , Kob Karl , Sitta Nicola
Published: March 2016

Recent findings casting doubts over the edibility of the European mushroom Tricholoma terreum are questioned on the basis of mycological and mycotoxicological considerations. Accordingly, T. terreum should remain listed among edible mushroom species.
Nanostructured MoS2 Nanorose/Graphene Nanoplatelet Hybrids for Electrocatalysis
Authors: Chua Chun Kiang , Loo Adeline Huiling , Pumera Martin
Published: March 2016

Tailoring and enhancing electrocatalytic activity is of the utmost importance from the viewpoints of sustainable energy and sensing. MoS2 and graphene show great promise for the electrocatalysis of many reactions. Given that both graphene and MoS2 are highly anisotropic in nature, with edge planes that are several orders of magnitude more catalytically active than basal planes, a new hybrid material with maximized edge‐plane density to provide efficient electron transfer, high catalytic activity, and conductive cores was engineered. The hybrid material consists of radial MoS2 nanosheets with a high density of edge planes and unsaturated active sulfur atoms as well as interspersed with conductive graphene nanoplatelets. This hybrid material exhibits excellent activity for the hydrogen evolution reaction and the detection of DNA nucleobases. Such a nanoengineered, nanostructured hybrid material may play a major role in future electrocatalytic devices.
One‐Pot Fabrication of Hierarchical Nanosheet‐Based TiO2–Carbon Hollow Microspheres for Anode Materials of High‐Rate Lithium‐Ion Batteries
Authors: Jin Zhaokui , Yang Mu , Wang Jingjing , Gao Hongyi , Lu Yunfeng , Wang Ge
Published: March 2016

Hierarchical and hollow nanostructures have recently attracted considerable attention because of their fantastic architectures and tunable property for facile lithium ion insertion and good cycling stability. In this study, a one‐pot and unusual carving protocol is demonstrated for engineering hollow structures with a porous shell. Hierarchical TiO2 hollow spheres with nanosheet‐assembled shells (TiO2 NHS) were synthesized by the sequestration between the titanium source and 2,2′‐bipyridine‐5,5′‐dicarboxylic acid, and kinetically controlled etching in trifluoroacetic acid medium. In addition, annealing such porous nanostructures presents the advantage of imparting carbon‐doped functional performance to its counterpart under different atmospheres. Such highly porous structures endow very large specifics surface area of 404 m2 g−1 and 336 m2 g−1 for the as‐prepared and calcination under nitrogen gas. C/TiO2 NHS has high capacity of 204 mA h g−1 at 1 C and a reversible capacity of 105 mA h g−1 at a high rate of 20 C, and exhibits good cycling stability and superior rate capability as an anode material for lithium‐ion batteries.
Formation and High Reactivity of the anti‐Dioxo Form of High‐Spin μ‐Oxodioxodiiron(IV) as the Active Species That Cleaves Strong C−H Bonds
Authors: Kodera Masahito , Ishiga Shin , Tsuji Tomokazu , Sakurai Katsutoshi , Hitomi Yutaka , Shiota Yoshihito , Sajith P. K. , Yoshizawa Kazunari , Mieda Kaoru , Ogura Takashi
Published: March 2016

Recently, it was shown that μ‐oxo‐μ‐peroxodiiron(III) is converted to high‐spin μ‐oxodioxodiiron(IV) through O−O bond scission. Herein, the formation and high reactivity of the anti‐dioxo form of high‐spin μ‐oxodioxodiiron(IV) as the active oxidant are demonstrated on the basis of resonance Raman and electronic‐absorption spectral changes, detailed kinetic studies, DFT calculations, activation parameters, kinetic isotope effects (KIE), and catalytic oxidation of alkanes. Decay of μ‐oxodioxodiiron(IV) was greatly accelerated on addition of substrate. The reactivity order of substrates is toluene<ethylbenzene≈cumene<trans‐β‐methylstyrene. The rate constants increased proportionally to the substrate concentration at low substrate concentration. At high substrate concentration, however, the rate constants converge to the same value regardless of the kind of substrate. This is explained by a two‐step mechanism in which anti‐μ‐oxodioxodiiron(IV) is formed by syn‐to‐anti transformation of the syn‐dioxo form and reacts with substrates as the oxidant. The anti‐dioxo form is 620 times more reactive in the C−H bond cleavage of ethylbenzene than the most reactive diiron system reported so far. The KIE for the reaction with toluene/[D8]toluene is 95 at −30 °C, which the largest in diiron systems reported so far. The present diiron complex efficiently catalyzes the oxidation of various alkanes with H2O2.
Electrophilic Activation of α,β‐Unsaturated Amides: Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ‐Butyrolactones
Authors: Zhang Ming , Kumagai Naoya , Shibasaki Masakatsu
Published: March 2016

Although catalytic asymmetric conjugate addition reactions have remarkably advanced over the last two decades, the application of less electrophilic α,β‐unsaturated carboxylic acid derivatives in this useful reaction manifold remains challenging. Herein, we report that α,β‐unsaturated 7‐azaindoline amides act as reactive electrophiles to participate in catalytic diastereo‐ and enantioselective vinylogous conjugate addition of γ‐butyrolactones in the presence of a cooperative catalyst comprising of a soft Lewis acid and a Brønsted base. Reactions mostly reached completion with as little as 1 mol % of catalyst loading to give the desired conjugate adducts in a highly stereoselective manner.
Site‐Selective Acylations with Tailor‐Made Catalysts
Authors: Huber Florian , Kirsch Stefan F.
Published: March 2016

The acylation of alcohols catalyzed by N,N‐dimethylamino pyridine (DMAP) is, despite its widespread use, sometimes confronted with substrate‐specific problems: For example, target compounds with multiple hydroxy groups may show insufficient selectivity for one hydroxyl, and the resulting product mixtures are hardly separable. Here we describe a concept that aims at tailor‐made catalysts for the site‐specific acylation. To this end, we introduce a catalyst library where each entry is constructed by connecting a variable and readily tuned peptide scaffold with a catalytically active unit based on DMAP. For selected examples, we demonstrate how library screening leads to the identification of optimized catalysts, and the substrates of interest can be converted with a markedly enhanced site‐selectivity compared with only DMAP. Furthermore, substrate‐optimized catalysts of this type can be used to selectively convert “their” substrate in the presence of structurally similar compounds, an important requisite for reactions with mixtures of substances.
Asymmetric Palladium‐Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides
Authors: Garlets Zachary J. , Parenti Kaia R. , Wolfe John P.
Published: March 2016

The synthesis of cyclic sulfamides by enantioselective Pd‐catalyzed alkene carboamination reactions between N‐allylsulfamides and aryl or alkenyl bromides is described. High levels of asymmetric induction (up to 95:5 e.r.) are achieved using a catalyst composed of [Pd2(dba)3] and (S)‐Siphos‐PE. Deuterium‐labelling studies indicate the reactions proceed through syn‐aminopalladation of the alkene and suggest that the control of syn‐ versus anti‐aminopalladation pathways is important for asymmetric induction.
ChemInform Abstract: Study of Phase Transformation in BaTe2O6 by in situ High‐Pressure X‐Ray Diffraction, Raman Spectroscopy, and First‐Principles Calculations.
Authors: Mishra K. K. , Achary S. Nagabhusan , Chandra Sharat , Ravindran T. R. , Pandey K. K. , Tyagi Avesh K. , Sharma Surinder M.
Published: March 2016

The title compound is synthesized by solid state reaction of a stoichiometric mixture of BaCO3 and TeO2 (air, 550 °C for 6 h, and 650 °C for 12 h).
ChemInform Abstract: Hydrogenation‐Induced Structure and Property Changes in the Rare‐Earth Metal Gallide NdGa: Evolution of a [GaH]2— Polyanion Containing Peierls‐Like Ga—H Chains.
Authors: Aangstroem Jonas , Johansson Robert , Sarkar Tapati , Soerby Magnus H. , Zlotea Claudia , Andersson Mikael S. , Nordblad Per , Scheicher Ralph H. , Haeussermann Ulrich , Sahlberg Martin
Published: March 2016

NdGaH1.66 and its deuterated analogue are obtained by heating NdGa with H2 or D2 (autoclave, 10—20 bar, 300 °C, up to 48 h) and characterized by powder neutron diffraction, thermal desorption mass spectrometry, and magnetic measurements.
ChemInform Abstract: High‐Pressure Study of Mn(BH4)2 Reveals a Stable Polymorph with High Hydrogen Density.
Authors: Filinchuk Yaroslav , et al.
Published: March 2016

α‐Mn(BH4)2 is prepared by high—energy ball milling of stoichiometric amounts of LiBH4 and MnCl2 or by metathesis reaction of the latter precursors in Et2O to yield NaMn2(BH4)2·2Et2O followed by desolvation under vacuum at 110 °C.
ChemInform Abstract: Ca6BaP4O17:Eu2+,Gd3+: A Yellow Emitting Long‐Lasting Phosphor with High Brightness and Long Afterglow Duration.
Authors: Guo Haijie , Wang Yuhua , Chen Wenbo , Zeng Wei , Li Gen , Li Yanyan
Published: March 2016

A series of phosphors, Ca6BaP4O17:0.02Eu2+,xGd 3+ (x = 0, 0.005, 0.01, 0.015, 0.02, 0.025) is synthesized by solid state reaction of CaCO3, BaCO3, NH4H2PO4, Gd2O3, and Eu2O3 (alumina crucible, 5% H2/N2 stream, 1280 °C, 10 h).
ChemInform Abstract: Design, Synthesis and Characterization of Near‐Infrared Long Persistent Phosphors Ca4(PO4)2O:Eu2+,R3+ (R: Lu, La, Gd, Ce, Tm, Y).
Authors: Chen Wenbo , Wang Yuhua , Zeng Wei , Li Gen , Guo Haijie
Published: March 2016

The title phosphors are prepared by solid state reactions of appropriate mixtures of CaCO3, NH4H2PO4, Ln2O3 (Ln: Eu, Lu, La, Gd, Tm), and CeO2 (alumina crucible, 1573 K, 6 h).
ChemInform Abstract: A Surfactant‐Thermal Method to Prepare Crystalline Thioantimonate for High‐Performance Lithium‐Ion Batteries.
Authors: Nie Lina , Zhang Yu , Xiong Wei‐Wei , Lim Teik‐Thye , Xu Rong , Yan Qingyu , Zhang Qichun
Published: March 2016

Crystalline [Me2NH][Sb4S5(S3)] is prepared by a surfactant solvothermal reaction of Sb2S3 and S (1:7.5) together with DMF, H2N‐NH2·H2O, and octylamine (autoclave, 160 °C, 6 d).
ChemInform Abstract: Synthesis and Characterization of Carbon‐Doped ZnSn(OH)6 with Enhanced Photoactivity by Hydrothermal Method.
Authors: Lu Hongxia , et al.
Published: March 2016

Submicrocubes of carbon‐doped ZnSn(OH)6 are hydrothermally synthesized from aqueous solutions of SnCl4, Zn(OAc)2, NaOH, and glucose as the carbon doping source (autoclave, 160 °C, 18 h).
ChemInform Abstract: The Electrochemical Synthesis of Polycationic Clusters.
Authors: Schulz Christopher , Daniels Joerg , Bredow Thomas , Beck Johannes
Published: March 2016

Electrochemical dissolution of elemental Te in ionic liquids (IL) or in liquid SO2 is studied under dry conditions.
ChemInform Abstract: Synthesis of Borophenes: Anisotropic, Two‐Dimensional Boron Polymorphs.
Authors: Oganov Artem R. , et al.
Published: March 2016

Atomically thin crystalline boron sheets (i.e.
ChemInform Abstract: One‐Step Synthesis of High‐Purity Li2BeF4 Molten Salt.
Authors: Zong Guoqiang , Cui Zhen‐Hua , Sun Xiao‐Gang , Xiao Ji‐Chang
Published: March 2016

The title compound is prepared by melting a mixture of (NH4)2BeF4 (purified by recrystallization to remove sulfate ions) and LiF according to a preset temperature program (graphite crucible, 650 °C, 3 h).
ChemInform Abstract: A New Magnesium‐Containing Aluminophosphate with a Zeolite‐Like Structure.
Authors: Jiao Xuejiao , Wang Yanyan , Mu Ying , Sun Yanjun , Li Jiyang
Published: March 2016

[PipH2] [Mg2Al6(PO4)8 (H2O)4] (PipH2: diprotonated piperazine) is prepared by hydrothermal reaction of a gel formed by Mg(O‐Ac)2 and Al2O3 in H3PO4 and in the presence of piperazine as a structure‐directing agent (autoclave, 180 °C, 3 d).
ChemInform Abstract: Crystal Chemistry of the New Families of Interstitial Compounds R6Mg23C (R: La, Ce, Pr, Nd, Sm, or Gd) and Ce6Mg23Z (Z: C, Si, Ge, Sn, Pb, P, As, or Sb).
Authors: Wrubl Federico , Manfrinetti Pietro , Pani Marcella , Solokha Pavlo , Saccone Adriana
Published: March 2016

The title compounds are prepared by melting mixtures of the elements twice at 1100 °C followed by annealing (Ta crucible, 700 °C, 14 d).
ChemInform Abstract: A Vanadium Chalcogenide Dicubane.
Authors: Li Tianyang , Baum Zachary J. , Goldberger Joshua E.
Published: March 2016

[V7S8Cl2(en)8]Cl4 is solvothermally synthesized from mixtures of VCl4, thiourea, and en (autoclave, 160 °C, 5 d; 61% yield).
ChemInform Abstract: Crystal Structure, Magnetic, Electronic, and Thermal Transport Properties of Ternary Compounds REReB4 (RE: Ce, Gd—Er, Yb).
Authors: Abramchuk Mykola , Schnelle Walter , Veremchuk Igor , Leithe‐Jasper Andreas , Grin Yuri , Gumeniuk Roman
Published: March 2016

LnReB4 with Ln: Tb—Er, Yb are synthesized from the elements by arc‐melting and subsequent annealing at temperatures between 1073 and 1823 K for 12—700 h.
ChemInform Abstract: Crystal Structure and Ionic Conductivity of the New Cobalt Polyphosphate NaCo(PO3)3.
Authors: Ben Smida Youssef , Guesmi Abderrahmen , Georges Samuel , Avdeev Maxim , Zid Mohamed Faouzi
Published: March 2016

The title compound is synthesized by solid state reaction of a stoichiometric mixture of NaNO3, Co(NO3)2, and NH4H2PO4 (porcelain crucible, 350 °C for 12 h and 650 °C for 24 h).
ChemInform Abstract: Syntheses, Crystal Structures and Electronic Structures of New Metal Chalcoiodides Bi2CuSe3I and Bi6Cu3S10I.
Authors: Liang I‐Chu , Bilc Daniel I. , Manoli Maria , Chang Wei‐Yun , Lin Wen‐Fu , Kyratsi Theodora , Hsu Kuei‐Fang
Published: March 2016

Crystals of Bi2CuSe3I (I) and Bi6Cu3S10I (II) are prepared by solid state reaction of stoichiometric mixtures of Bi, CuI (and Cu for II), and Se or S at 400 °C.
ChemInform Abstract: Catalytic Asymmetric Sulfenylation to Structurally Diverse Dithioketals.
Authors: Liao Kui , Zhou Feng , Yu Jin‐Sheng , Gao Wei‐Ming , Zhou Jian
Published: March 2016

The first highly enantioselective synthesis of dithioketals via dihydroquinine catalytic asymmetric sulfenylation is introduced.
ChemInform Abstract: A New Class of Squaramide‐Containing Phase‐Transfer Catalysts: Application to Asymmetric Fluorination of β‐Keto Esters.
Authors: Wang Bin , He Yingdong , Fu Xuancheng , Wei Zhonglin , Lin Yingjie , Duan Haifeng
Published: March 2016

Several catalysts are synthesized and their efficiency in the asymmetric fluorination of keto esters is tested.
ChemInform Abstract: Divergent Synthesis of Indole‐Fused Polycycles via Rh(II)‐Catalyzed Intramolecular [3 + 2] Cycloaddition and C—H Functionalization of Indolyltriazoles.
Authors: Zhang Yong‐Sheng , Tang Xiang‐Ying , Shi Min
Published: March 2016

A novel and efficient rhodium catalyzed Intramolecular [3 + 2] cycloaddition and C—H functionalization of indolyltriazoles to give access to polycyclic pyrroloindoles and azepino[4,5‐b]indoles is presented.
ChemInform Abstract: Diels—Alder Reactions of Arynes in situ Generated from DA Reaction Between Bis‐1,3‐diynes and Alkynes.
Authors: Zhang Ming‐Xing , Shan Wei , Chen Zhao , Yin Jun , Yu Guang‐Ao , Liu Sheng Hua
Published: March 2016

Diels—Alder cycloadditions of arynes, in situ generated from 1,3‐diynes (I), and dienophiles, such as furans, cyclopentadiene, and pyrrole are developed.
ChemInform Abstract: Transformation of N,N‐Diisopropylarylmethylamines into N‐Isopropylarylmethylamines with Molecular Iodine.
Authors: Ezawa Masatoshi , Moriyama Katsuhiko , Togo Hideo
Published: March 2016

Optimized conditions allow the efficient removal of one isopropyl group from diisopropylamines (I), whereas the reaction of related amines (III) is less effective.
ChemInform Abstract: A Convenient Alternative for the Selective Oxidation of Alcohols by Silica Supported TEMPO Using Dioxygen as the Final Oxidant.
Authors: Shakir Ahmed Juwad , Paraschivescu Codruta , Matache Mihaela , Tudose Madalina , Mischie Alice , Spafiu Felicia , Ionita Petre
Published: March 2016

Various primary and secondary alcohols (I) and (III) are oxidized to the corresponding aldehydes (II) and ketones (IV), resp., using silica supported TEMPO as a heterogeneous catalyst and nitrosonium tetrafluoroborate as a co‐catalyst.
ChemInform Abstract: Tribromoisocyanuric Acid as a Green Reagent for Benzylic Bromination of Alkylarenes.
Authors: de Almeida Leonardo S. , Esteves Pierre M. , de Mattos Marcio C. S.
Published: March 2016

The title reaction affords benzyl bromides (II) and (IV) in the absence of any catalyst or light irradiation.
ChemInform Abstract: Molybdenum Hexacarbonyl Mediated Synthesis of Indolin‐2‐one & Azaindolin‐2‐one under Catalyst Free Conditions.
Authors: Patil Vikas S. , Pal Shyam S. , Pathare Ramdas S. , Reddy L. K. K. , Pathak Arunendra
Published: March 2016

A very efficient and catalyst free method for the synthesis of substituted indolin‐2‐one and azaindolin‐2‐one derivatives is developed.
ChemInform Abstract: N‐(Pyridin‐2‐yl)benzamide: Efficient Ligand for the Nickel Catalyzed Chan—Lam Cross‐Coupling Reaction.
Authors: Keesara Srinivas
Published: March 2016

The cross‐coupling of anilines and alkyl amines with arylboronic acids proceeds in the presence of the title ligand to give secondary and tertiary aryl amines in moderate to good yields.
ChemInform Abstract: Ring‐Closing Metathesis with Vicinal Dibromoalkenes as Protected Alkynes: A Synthetic Approach to Macrocyclic Enynes.
Authors: Karabiyikoglu Sedef , Iafe Robert G. , Merlic Craig A.
Published: March 2016

Triene substrates containing an (E)‐dibromo‐tetrasubstituted alkene moiety participate in selective ene‐ene ring‐closing metathesis reactions.
ChemInform Abstract: Microwave‐Assisted Telescoped Cross Metathesis‐Ring Closing Aza‐Michael Reaction Sequence: Step‐Economical Access to Nicotine—Lobeline Hybrid Analogues.
Authors: Drege E. , Oko J. , Venot P.‐E. , Gigant N. , Joseph D.
Published: March 2016

The sequence for the access to nicotine‐natural nicotinic acetylcholine receptor ligand hybrids includes a cross‐metathesis and a ring‐closing step.