bluuebunny/crossref_metadata_2025 huggingface dataset:
Melatonin Ameliorates Post-Stroke Cognitive Impairment in Mice by Inhibiting Excessive Mitophagy
Authors: Shi Yan , Fang Qian , Hu Yue , Mi Zhaoyu , Luo Shuting , Gan Yaoxue , Yuan Shishan
Published: May 2024

Post-stroke cognitive impairment (PSCI) remains the most common consequence of ischemic stroke. In this study, we aimed to investigate the role and mechanisms of melatonin (MT) in improving cognitive dysfunction in stroke mice. We used CoCl2-induced hypoxia-injured SH-SY5Y cells as a cellular model of stroke and photothrombotic-induced ischemic stroke mice as an animal model. We found that the stroke-induced upregulation of mitophagy, apoptosis, and neuronal synaptic plasticity was impaired both in vivo and in vitro. The results of the novel object recognition test and Y-maze showed significant cognitive deficits in the stroke mice, and Nissl staining showed a loss of neurons in the stroke mice. In contrast, MT inhibited excessive mitophagy both in vivo and in vitro and decreased the levels of mitophagy proteins PINK1 and Parkin, and immunofluorescence staining showed reduced co-localization of Tom20 and LC3. A significant inhibition of mitophagy levels could be directly observed under transmission electron microscopy. Furthermore, behavioral experiments and Nissl staining showed that MT ameliorated cognitive deficits and reduced neuronal loss in mice following a stroke. Our results demonstrated that MT inhibits excessive mitophagy and improves PSCI. These findings highlight the potential of MT as a preventive drug for PSCI, offering promising therapeutic implications.
Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys
Authors: Kösters Peter , Cazorla-Vázquez Salvador , Krüger René , Daniel Christoph , Vonbrunn Eva , Amann Kerstin , Engel Felix B.
Published: May 2024

Uncovering the function of understudied G protein-coupled receptors (GPCRs) provides a wealth of untapped therapeutic potential. The poorly understood adhesion GPCR Gpr126 (Adgrg6) is widely expressed in developing kidneys. In adulthood, Gpr126 expression is enriched in parietal epithelial cells (PECs) and epithelial cells of the collecting duct and urothelium. Whether Gpr126 plays a role in kidney disease remains unclear. Here, we characterized Gpr126 expression in diseased kidneys in mice, rats, and humans. RT-PCR data show that Gpr126 expression is altered in kidney disease. A quantitative RNAscope® analysis utilizing cell type-specific markers revealed that Gpr126 expression upon tubular damage is mainly increased in cell types expressing Gpr126 under healthy conditions as well as in cells of the distal and proximal tubules. Upon glomerular damage, an increase was mainly detected in PECs. Notably, Gpr126 expression was upregulated in an ischemia/reperfusion model within hours, while upregulation in a glomerular damage model was only detected after weeks. An analysis of kidney microarray data from patients with lupus nephritis, IgA nephropathy, focal segmental glomerulosclerosis (FSGS), hypertension, and diabetes as well as single-cell RNA-seq data from kidneys of patients with acute kidney injury and chronic kidney disease indicates that GPR126 expression is also altered in human kidney disease. In patients with FSGS, an RNAscope® analysis showed that GPR126 mRNA is upregulated in PECs belonging to FSGS lesions and proximal tubules. Collectively, we provide detailed insights into Gpr126 expression in kidney disease, indicating that GPR126 is a potential therapeutic target.
A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells
Authors: Polini Beatrice , Zallocco Lorenzo , Gado Francesca , Ferrisi Rebecca , Ricardi Caterina , Zuccarini Mariachiara , Carnicelli Vittoria , Manera Clementina , Ronci Maurizio , Lucacchini Antonio , Zucchi Riccardo , Giusti Laura , Chiellini Grazia
Published: May 2024

Neurodegenerative diseases (NDDs) are progressive multifactorial disorders of the nervous system sharing common pathogenic features, including intracellular misfolded protein aggregation, mitochondrial deficit, and inflammation. Taking into consideration the multifaceted nature of NDDs, development of multitarget-directed ligands (MTDLs) has evolved as an attractive therapeutic strategy. Compounds that target the cannabinoid receptor type II (CB2R) are rapidly emerging as novel effective MTDLs against common NDDs, such as Alzheimer’s disease (AD). We recently developed the first CB2R bitopic/dualsteric ligand, namely FD22a, which revealed the ability to induce neuroprotection with fewer side effects. To explore the potential of FD22a as a multitarget drug for the treatment of NDDs, we investigated here its ability to prevent the toxic effect of β-amyloid (Aβ25–35 peptide) on human cellular models of neurodegeneration, such as microglia (HMC3) and glioblastoma (U87-MG) cell lines. Our results displayed that FD22a efficiently prevented Aβ25–35 cytotoxic and proinflammatory effects in both cell lines and counteracted β-amyloid-induced depression of autophagy in U87-MG cells. Notably, a quantitative proteomic analysis of U87-MG cells revealed that FD22a was able to potently stimulate the autophagy–lysosomal pathway (ALP) by activating its master transcriptional regulator TFEB, ultimately increasing the potential of this novel CB2R bitopic/dualsteric ligand as a multitarget drug for the treatment of NDDs.
Clinical Case of Mild Tatton–Brown–Rahman Syndrome Caused by a Nonsense Variant in DNMT3A Gene
Authors: Bostanova Fatima , Levchenko Olga , Sharova Margarita , Semenova Natalia
Published: May 2024

Tatton–Brown–Rahman syndrome is a rare autosomal dominant hereditary disease caused by pathogenic variants in the DNMT3A gene, which is an important participant in epigenetic regulation, especially during embryonic development, and is highly expressed in all tissues. The main features of the syndrome are high growth, macrocephaly, intellectual disability, and facial dysmorphic features. We present a clinical case of Tatton–Brown–Rahman syndrome in a ten-year-old boy with macrocephaly with learning difficulties, progressive eye impairment, and fatigue suspected by a deep learning-based diagnosis assistance system, Face2Gene. The proband underwent whole-exome sequencing, which revealed a recurrent nonsense variant in the 12th exon of the DNMT3A, leading to the formation of a premature stop codon—NM_022552.5:c.1443C>A (p.Tyr481Ter), in a heterozygous state. This variant was not found in parents, confirming its de novo status. The patient case described here contributes to the understanding of the clinical diversity of Tatton–Brown–Raman syndrome with a mild clinical presentation that expands the phenotypic spectrum of the syndrome. We report the first recurrent nonsense variant in the DNMT3A gene, suggesting a mutational hot-spot. Differential diagnoses of this syndrome with Sotos syndrome, Weaver syndrome, and Cowden syndrome, as well as molecular confirmation, are extremely important, since the presence of certain types of pathogenic variants in the DNMT3A gene significantly increases the risk of developing acute myeloid leukemia.
Emotional Dysregulation and Sleep Problems: A Transdiagnostic Approach in Youth
Authors: Sesso Gianluca , Guccione Fulvio , Pisano Simone , Valente Elena , Narzisi Antonio , Berloffa Stefano , Fantozzi Pamela , Viglione Valentina , Milone Annarita , Masi Gabriele
Published: May 2024

Background: Sleep is a complex phenomenon that affects several aspects of life, including cognitive functioning, emotional regulation, and overall well-being. Sleep disturbances, especially during adolescence, can negatively impact emotional regulation, making it a critical factor in targeting psychopathology. Methods: This study explores the interplay between emotional dysregulation (ED) and sleep patterns in a sample of 90 adolescent patients by means of self- and parent-rated clinical measures. Results: Our findings reveal a bidirectional relationship between ED and sleep problems. Adolescents with higher affective instability experience poorer sleep quality, while those with worse sleep quality exhibit higher internalizing problems. Additionally, emotional reactivity is associated with disrupted circadian rhythms. Conclusions: These results emphasize the significance of addressing sleep problems in the context of psychopathology treatment, potentially leading to improved outcomes. Further research is needed to determine the most effective treatment strategies, including nonpharmacological and pharmacological interventions. Understanding the intricate relationship between sleep problems and emotion regulation offers insights for more targeted and effective treatment approaches for youths struggling with ED.
Knowledge and Attitudes towards Medical Emergencies among Dentists in Iași, Romania
Authors: Murariu Alice , Bobu Livia , Stoleriu Simona , Vasluianu Roxana-Ionela , Iovan Gianina , Gelețu Gabriela Luminița , Toma Vasilica , Baciu Elena-Raluca
Published: May 2024

The aim of this study was to evaluate the level of knowledge of resident dentists and new graduates regarding the etiology, clinical diagnosis, and treatment of the main medical emergency conditions. The study included a sample of 152 new graduates and residents in the first, second, and third year of training in Prosthodontics and General Dentistry from the Faculty of Dental Medicine in Iasi, Romania. Their level of knowledge and the attitudes were assessed using a questionnaire with 24 questions, divided into four sections. The differences among groups were identified using the chi-square test (p < 0.05). A high level of knowledge was found among the three groups of subjects for the questions regarding the recognition of clinical signs in hypoglycemic crisis (88–100%), in anaphylactic shock (83.3–94.5%), and the treatment of angina pectoris (76.2–84.2%). In contrast, a low level of knowledge was found for the questions regarding pulse evaluation in the case of an emergency (26.3–35.7%), the parameters of normal breathing (28.9–43%), and the treatment of hypoglycemic crisis (27.8–44.8%). The study indicated that the dentists had a moderate understanding of dental office medical emergencies and preferred practical training over theoretical courses.
The Use of Statins as an Adjunctive Periodontal Disease Treatment: Systematic Review and Meta-Analysis
Authors: Greethurst Alice Rose , Galletti Cosimo , Lo Giudice Roberto , Nart José , Vallés Cristina , Real-Voltas Francisco , Gay-Escoda Cosme , Marchetti Enrico
Published: May 2024

Background: the purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis. Methods: Electronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant articles. Eligibility was based on inclusion criteria which included Randomized Controlled Trials (RCTs) published after 2010, where the periodontal variables were assessed before and after periodontal treatment in combination with a statin administration. The risk of bias was assessed with the ROBINS-2 tool. The outcome variables were probing depth, clinical attachment level, bleeding on probing, and bone fill in systematically healthy patients, patients with type 2 diabetes, and smokers. Results: Out of 119 potentially eligible articles, 18 randomized controlled trials were included with a total of 1171 participants. The data retrieved from the meta-analysis showed the positive effect that statins have as an adjunctive periodontal disease treatment. When comparing the different types of statins, the PD reduction in the Simvastatin group was significantly higher than the Atorvastatin group at 6 months and at 9 months, while no differences between statins were found for the rest of the outcomes. Over 66% of the articles presented an overall risk of bias with some concerns, making this a limitation of this present RCT. Conclusions: The adjunct administration of statins has proven to have a positive effect on the periodontium by improving both clinical and radiographic parameters by a considerable margin.
A Data Attack Detection Framework for Cryptography-Based Secure Aggregation Methods in 6G Intelligent Applications
Authors: Sun Zhe , Liang Junxi , Yin Lihua , Xu Pingchuan , Li Chao , Wan Junping , Wang Hanyi
Published: May 2024

Eagerly anticipated, 6G networks are attributed with a variety of characteristics by researchers. A pivotal characteristic of 6G networks is the deep integration of sensing and networking, along with intelligent network applications operating on top of this infrastructure. To optimally harness the data collected by sensors distributed across various locations, the training paradigm of the new generation of 6G intelligence applications aligns naturally with the federated-learning paradigm. The exposure of gradients in federated learning to inversion attacks is a critical concern. To address this, cryptography-based secure aggregation methods are commonly implemented to protect the privacy and confidentiality of gradients. However, the semantic meaninglessness of encrypted data makes it difficult to assess the correctness, availability, and source legitimacy of participants’ data. In this paper, we propose a data attack detection framework for cryptography-based secure aggregation methods in 6G intelligence applications that address the security vulnerabilities associated with encrypted data obscurity. We employ a suite of encrypted-data-auditing techniques to prevent data-aggregation errors, data poisoning, and illegal data sources. Additionally, we have compared a series of promising security methods, analyzed, and provided recommendations for the most suitable security approaches in specific 6G scenarios.
A Multi-Step-Ahead Photovoltaic Power Forecasting Approach Using One-Dimensional Convolutional Neural Networks and Transformer
Authors: Moon Jihoon
Published: May 2024

Due to environmental concerns about the use of fossil fuels, renewable energy, especially solar energy, is increasingly sought after for its ease of installation, cost-effectiveness, and versatile capacity. However, the variability in environmental factors poses a significant challenge to photovoltaic (PV) power generation forecasting, which is crucial for maintaining power system stability and economic efficiency. In this paper, a novel muti-step-ahead PV power generation forecasting model by integrating single-step and multi-step forecasts from various time resolutions was developed. One-dimensional convolutional neural network (CNN) layers were used for single-step forecasting to capture specific temporal patterns, with the transformer model improving multi-step forecasting by leveraging the combined outputs of the CNN. This combination can provide accurate and immediate forecasts as well as the ability to identify longer-term generation trends. Using the DKASC-ASA-1A and 1B datasets for empirical validation, several preprocessing methods were applied and a series of experiments were conducted to compare the performance of the model with other widely used deep learning models. The framework proved to be capable of accurately predicting multi-step-ahead PV power generation at multiple time resolutions.
Predicting Impacts of Climate Change on Suitable Distribution of Critically Endangered Tree Species Yulania zenii (W. C. Cheng) D. L. Fu in China
Authors: Wang Haoran , Zhi Feiyun , Zhang Guangfu
Published: May 2024

The ancient Magnoliaceae family is being seriously threatened by climate change, especially for Yulania trees under threat. Little is currently understood regarding the appropriate geographic range of Yulania zenii, as well as how it has reacted to various climate situations from past to present. Here, we chose MaxEnt for final modeling after first using ten Biomod2 models to approximate its possible distribution in China. The findings indicated that the three main environmental parameters impacting its distribution were the monthly mean diurnal range of temperature, the precipitation seasonality of variation coefficient, and elevation. Currently, its appropriate distribution is primarily in southern Anhui, eastern Hunan, central Hubei, southern Jiangsu, and both northern Jiangxi and Zhejiang. The total suitable area of Y. zenii was found to be 14.68 × 104 km2, only taking up 1.53% of China’s total territory, which is larger than known. During the Last Interglacial and Middle Holocene, its suitable habitats were larger than they are currently, exhibiting a relatively continuous distribution. Under various future climate scenarios, its suitable habitats may averagely decrease by 20.26% compared with the current case, and these habitats may become more fragmented. Collectively, the centroid of Y. zenii is expected to migrate towards the southeast in the future. Therefore, our findings demonstrate, for the first time, that climate change has had an adverse effect on this species in terms of its distribution from the past to the current and into the future. Our study could contribute to the conservation, management, introduction, and cultivation of Y. zenii in China and provide a reference for other endangered Yulania species in this country under the conditions of climate change.
Densification of Delignified Wood: Influence of Chemical Composition on Wood Density, Compressive Strength, and Hardness of Eurasian Aspen and Scots Pine
Authors: Mania Przemysław , Kupfernagel Carlo , Curling Simon
Published: May 2024

The densification of solid wood is a well-studied technique that aims to increase the strength and hardness of the material by permanently compressing the wood tissue. To optimise the densification process in this study, a pre-treatment with sodium sulphite was used (delignification). With delignification prior to densification, one achieves higher compression ratios and better mechanical properties compared to densification without pre-treatment. The reactivity of syringyl (dominant in hardwoods) and guaiacyl (dominant in softwoods) lignin towards delignification is different. The influences of this difference on the delignification and densification of softwoods and hardwoods need to be investigated. This study aimed to densify wood after delignification and investigate how variations in chemical composition between coniferous and deciduous species affect the densification process. Scots pine and Eurasian aspen specimens with a similar initial density were investigated to study the influence of the different lignin chemistry in softwoods and hardwoods on the densification process. Both timbers were delignified with sodium sulphite and sodium hydroxide and subsequently densified. While the delignification was twice as efficient in aspen than in pine, the compression ratios were almost identical in both species. The Brinell hardness and compressive strength showed a more significant increase in aspen than in Scots pine; however, one exception was the compressive strength in a radial direction, which increased more effectively in Scots pine. Scanning electron microscopy (SEM) revealed the microstructure of densified aspen and Scots pine, showing the crushing and collapse of the cells.
MADDPG-Based Offloading Strategy for Timing-Dependent Tasks in Edge Computing
Authors: Wang Yuchen , Huang Zishan , Wei Zhongcheng , Zhao Jijun
Published: May 2024

With the increasing popularity of the Internet of Things (IoT), the proliferation of computation-intensive and timing-dependent applications has brought serious load pressure on terrestrial networks. In order to solve the problem of computing resource conflict and long response delay caused by concurrent application service applications from multiple users, this paper proposes an improved edge computing timing-dependent, task-offloading scheme based on Multi-Agent Deep Deterministic Policy Gradient (MADDPG) that aims to shorten the offloading delay and improve the resource utilization rate by means of resource prediction and collaboration among multiple agents to shorten the offloading delay and improve the resource utilization. First, to coordinate the global computing resource, the gated recurrent unit is utilized, which predicts the next computing resource requirements of the timing-dependent tasks according to historical information. Second, the predicted information, the historical offloading decisions and the current state are used as inputs, and the training process of the reinforcement learning algorithm is improved to propose a task-offloading algorithm based on MADDPG. The simulation results show that the algorithm reduces the response latency by 6.7% and improves the resource utilization by 30.6% compared with the suboptimal benchmark algorithm, and it reduces nearly 500 training rounds during the learning process, which effectively improves the timeliness of the offloading strategy.
Complications of Brentuximab Therapy in Patients with Hodgkin’s Lymphoma and Concurrent Autoimmune Pathology—A Case Series
Authors: Preda Oana Diana , Bădeliță Sorina , Ursuleac Iulia , Irimia Ruxandra Maria , Balanica Sonia , Cojocaru Monica , Cotruta Cristina , Dobrea Camelia , Coriu Daniel
Published: May 2024

Background: Brentuximab Vedotin (BV) has revolutionized the treatment landscape for Hodgkin’s lymphoma, yet its effects on pre-existing autoimmune disorders remain elusive. Methods: Here, we present four cases of patients with concurrent autoimmune conditions—Crohn’s disease, vitiligo, type I diabetes, and minimal change disease—undergoing BV therapy for Hodgkin’s lymphoma. The patients were treated with A-AVD instead of ABVD due to advanced-stage disease with high IPI scores. Results: Our findings reveal the surprising and complex interplay between BV exposure and autoimmune manifestations, highlighting the need for multidisciplinary collaboration in patient management. Notably, the exacerbation of autoimmune symptoms was observed in the first three cases where T-cell-mediated autoimmunity predominated. Additionally, BV exposure precipitated autoimmune thrombocytopenia in the vitiligo patient, underscoring the profound disruptions in immune regulation. Conversely, in the minimal change disease case, a disease characterized by a blend of B- and T-cell-mediated immunity, the outcome was favorable. Conclusions: This paper underscores the critical importance of vigilance toward autoimmune flare-ups induced by BV in patients with concurrent autoimmune conditions, offering insights for tailored patient care.
Gas Chromatography-Mass Spectrometry Metabolites and Transcriptome Profiling Reveal Molecular Mechanisms and Differences in Terpene Biosynthesis in Two Torrya grandis Cultivars during Postharvest Ripening
Authors: Zhang Zuying , Gao Lingling , Tao Liu , Wu Tianfang , Suo Jinwei , Hu Yuanyuan , Yu Weiyu , Wu Jiasheng , Song Lili
Published: May 2024

Terpene aroma compounds are key quality attributes of postharvest Torreya grandis nuts, contributing to their commercial value. However, terpene biosynthesis and regulatory networks in different T. grandis cvs. are still poorly understood. Here, chief cvs. ‘Xi Fei’ and ‘Xiangya Fei’ were investigated for their differences in terpene biosynthesis and gene expression levels during postharvest ripening using headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography–mass spectrometry (GC-MS) and transcriptomic datasets. A total of 28 and 22 aroma compounds were identified in ‘Xi Fei’ and ‘Xiangya Fei’, respectively. Interestingly, differences in aroma composition between the two cvs. were mostly attributed to D-limonene and α-pinene levels as key determinants in Torreya nuts’ flavor. Further, transcriptome profiling, correlation analysis, and RT-qPCR annotated two novel genes, TgTPS1 in ‘Xi Fei’ and TgTPS2 in ‘Xiangya Fei’, involved in terpene biosynthesis. In addition, six transcription factors (TFs) with comparable expression patterns to TgTPS1 and four TFs to TgTPS2 were identified via correlation analysis of a volatile and transcriptome dataset to be involved in terpene biosynthesis. Our study provides novel insight into terpene biosynthesis and its regulation at the molecular level in T. grandis nut and presents a valuable reference for metabolic engineering and aroma improvement in this less explored nut.
NinaB and BCO Collaboratively Participate in the β-Carotene Catabolism in Crustaceans: A Case Study on Chinese Mitten Crab Eriocheir sinensis
Authors: Zhang Min , Xiong Jingyi , Yang Zonglin , Zhu Boxiang , Wu Yuting , Chen Xiaowu , Wu Xugan
Published: May 2024

Carotenoid cleavage oxygenases can cleave carotenoids into a range of biologically important products. Carotenoid isomerooxygenase (NinaB) and β, β-carotene 15, 15′-monooxygenase (BCO1) are two important oxygenases. In order to understand the roles that both oxygenases exert in crustaceans, we first investigated NinaB-like (EsNinaBl) and BCO1-like (EsBCO1l) within the genome of Chinese mitten crab (Eriocheir sinensis). Their functions were then deciphered through an analysis of their expression patterns, an in vitro β-carotene degradation assay, and RNA interference. The results showed that both EsNinaBl and EsBCO1l contain an RPE65 domain and exhibit high levels of expression in the hepatopancreas. During the molting stage, EsNinaBl exhibited significant upregulation in stage C, whereas EsBCO1l showed significantly higher expression levels at stage AB. Moreover, dietary supplementation with β-carotene resulted in a notable increase in the expression of EsNinaBl and EsBCO1l in the hepatopancreas. Further functional assays showed that the EsNinaBl expressed in E. coli underwent significant changes in its color, from orange to light; in addition, its β-carotene cleavage was higher than that of EsBCO1l. After the knockdown of EsNinaBl or EsBCO1l in juvenile E. sinensis, the expression levels of both genes were significantly decreased in the hepatopancreas, accompanied by a notable increase in the redness (a*) values. Furthermore, a significant increase in the β-carotene content was observed in the hepatopancreas when EsNinaBl-mRNA was suppressed, which suggests that EsNinaBl plays an important role in carotenoid cleavage, specifically β-carotene. In conclusion, our findings suggest that EsNinaBl and EsBCO1l may exhibit functional co-expression and play a crucial role in carotenoid cleavage in crabs.
Measuring the Flight Trajectory of a Free-Flying Moth on the Basis of Noise-Reduced 3D Point Cloud Time Series Data
Authors: Nishisue Koji , Sugiura Ryo , Nakano Ryo , Shibuya Kazuki , Fukuda Shinji
Published: May 2024

Pest control is crucial in crop production; however, the use of chemical pesticides, the primary method of pest control, poses environmental issues and leads to insecticide resistance in pests. To overcome these issues, laser zapping has been studied as a clean pest control technology against the nocturnal cotton leafworm, Spodoptera litura, which has high fecundity and causes severe damage to various crops. For better sighting during laser zapping, it is important to measure the coordinates and speed of moths under low-light conditions. To achieve this, we developed an automatic detection pipeline based on point cloud time series data from stereoscopic images. We obtained 3D point cloud data from disparity images recorded under infrared and low-light conditions. To identify S. litura, we removed noise from the data using multiple filters and a support vector machine. We then computed the size of the outline box and directional angle of the 3D point cloud time series to determine the noisy point clouds. We visually inspected the flight trajectories and found that the size of the outline box and the movement direction were good indicators of noisy data. After removing noisy data, we obtained 68 flight trajectories, and the average flight speed of free-flying S. litura was 1.81 m/s.
The Roadmap toward Personalized Medicine: Challenges and Opportunities
Authors: Cinti Caterina , Trivella Maria Giovanna , Joulie Michael , Ayoub Hussein , Frenzel Monika
Published: May 2024

In 2019, the International Consortium for Personalised Medicine (ICPerMed) developed a vision on how the use of personalized medicine (PM) approaches will promote “next-generation” medicine in 2030 more firmly centered on the individual’s personal characteristics, leading to improved health outcomes within sustainable healthcare systems through research, development, innovation, and implementation for the benefit of patients, citizens, and society. Nevertheless, there are significant hurdles that healthcare professionals, researchers, policy makers, and patients must overcome to implement PM. The ICPerMed aims to provide recommendations to increase stakeholders’ awareness on actionable measures to be implemented for the realization of PM. Starting with best practice examples of PM together with consultation of experts and stakeholders, a careful analysis that underlined hurdles, opportunities, recommendations, and information, aiming at developing knowledge on the requirements for PM implementation in healthcare practices, has been provided. A pragmatic roadmap has been defined for PM integration into healthcare systems, suggesting actions to overcome existing barriers and harness the potential of PM for improved health outcomes. In fact, to facilitate the adoption of PM by diverse stakeholders, it is mandatory to have a comprehensive set of resources tailored to stakeholder needs in critical areas of PM. These include engagement strategies, collaboration frameworks, infrastructure development, education and training programs, ethical considerations, resource allocation guidelines, regulatory compliance, and data management and privacy.
Management Considerations for Cervical Corpectomy: Updated Indications and Future Directions
Authors: Foreman Marco , Foster Devon , Gillam Wiley , Ciesla Christopher , Lamprecht Chris , Lucke-Wold Brandon
Published: May 2024

Together, lower back and neck pain are among the leading causes of acquired disability worldwide and have experienced a marked increase over the past 25 years. Paralleled with the increasing aging population and the rise in chronic disease, this trend is only predicted to contribute to the growing global burden. In the context of cervical neck pain, this symptom is most often a manifestation of cervical degenerative disc disease (DDD). Traditionally, multilevel neck pain related to DDD that is recalcitrant to both physical and medical therapy can be treated with a procedure known as cervical corpectomy. Presently, there are many flavors of cervical corpectomy; however, the overarching goal is the removal of the pain-generating disc via the employment of the modern anterior approach. In this review, we will briefly detail the pathophysiological mechanism behind DDD, overview the development of the anterior approach, and discuss the current state of treatment options for said pathology. Furthermore, this review will also add to the current body of literature surrounding updated indications, surgical techniques, and patient outcomes related to cervical corpectomy. Finally, our discussion ends with highlighting the future direction of cervical corpectomy through the introduction of the “skip corpectomy” and distractable mesh cages.
Recent Advances in Corrosion Inhibition of Bonded NdFeB Magnets
Authors: Primc Gregor , Mozetič Miran
Published: May 2024

Bonded permanent NdFeB magnets are useful in numerous applications, including electric vehicles, and the demand is steadily increasing. A major drawback is corrosion due to inadequate wetting of the magnetic particles by liquid polymers such as polyphenylene sulfide or polyamide. Recently reported methods for corrosion inhibition are summarized, and their applicability is critically evaluated. The phosphorylation of magnetic particles inhibits corrosion but does not enable appropriate properties in harsh environments. The same applies to metallic coatings, which usually contain aluminum and zinc. Advanced epoxy adhesives are a promising solution, although some authors have reported inadequate corrosion resistance. The application of composite coatings seems like an appropriate solution, but the exact mechanisms are yet to be studied.
Influence of Growth Process on Suppression of Surface Morphological Defects in 4H-SiC Homoepitaxial Layers
Authors: Pei Yicheng , Yuan Weilong , Li Yunkai , Guo Ning , Zhang Xiuhai , Liu Xingfang
Published: May 2024

To address surface morphological defects that have a destructive effect on the epitaxial wafer from the aspect of 4H-SiC epitaxial growth, this study thoroughly examined many key factors that affect the density of defects in 4H-SiC epitaxial wafer, including the ratio of carbon to silicon, growth time, application of a buffer layer, hydrogen etching and other process parameters. Through systematic experimental verification and data analysis, it was verified that when the carbon–silicon ratio was accurately controlled at 0.72, the density of defects in the epitaxial wafer was the lowest, and its surface flatness showed the best state. In addition, it was found that the growth of the buffer layer under specific conditions could effectively reduce defects, especially surface morphology defects. This provides a new idea and method for improving the surface quality of epitaxial wafers. At the same time, we also studied the influence of hydrogen etching on the quality of epitaxial wafers. The experimental results show that proper hydrogen etching can optimize surface quality, but excessive etching may lead to the exposure of substrate defects. Therefore, it is necessary to carefully control the conditions of hydrogen etching in practical applications to avoid adverse effects. These findings have important guiding significance for optimizing the quality of epitaxial wafers.
Surface Topography in Cutting-Speed-Direction Ultrasonic-Assisted Turning
Authors: Nguyen Thanh-Trung , Vu Toan-Thang , Nguyen Thanh-Dong
Published: May 2024

Ultrasonic vibration has been employed to assist in turning, introducing intermittent machining to reduce average cutting force, minimize tool wear, and enhance machining efficiency, thereby improving surface roughness. However, achieving intermittent cutting necessitates specific conditions, with a cutting speed or feed rate falling below the critical speed associated with the ultrasonic vibration parameters. This study presents a theoretical model for surface formation in cutting-speed-direction ultrasonic-assisted turning (CUAT), covering both continuous and intermittent machining regimes. Experimental validation was conducted on C45 carbon steel and 201 stainless steel to demonstrate the applicability of the theoretical model across different materials. Digital microscope analysis revealed 3D topography consistency with the theoretical formula. Surface roughness evaluations were performed for both CUAT and CT (conventional turning) methods. The results indicated a significant reduction in roughness Ra for C45 steel samples machined with CUAT, up to 80% compared to CT at a cutting speed of 20 m/min, while only exhibiting slight fluctuations when turning 201 stainless steel. Detailed analysis and explanation of these phenomena are presented herein.
Antenna Array Design Based on Low-Temperature Co-Fired Ceramics
Authors: Teng Lu , Yu Zhongjun , Zhu Dali , Hao Chengxiang , Jiang Na
Published: May 2024

With the continuous development of wireless communication technology, the frequency band of 6G communication systems is moving towards higher frequencies such as millimeter waves and terahertz. In such high-frequency situations, wireless transmission requires antenna modules to be provided with characteristics of miniaturization, high integration, and high gain, which presents new challenges to the development of antenna technology. In this article, a 4 × 4 antenna array using multilayered low-temperature co-fired ceramic is proposed, operating in W-band, with a feeding network based on substrate-integrated waveguide, and an antenna element formed through the combination of a substrate-integrated cavity and surface parasitic patches, which guaranteed the array to possess the advantages of high integration and high gain. Combined with the substrate-integrated waveguide to a rectangular waveguide transition structure designed in the early stage, a physical array with a standard metal rectangular waveguide interface was fabricated and tested. The test results show that the gain of the antenna array is higher than 18 dBi from 88 to 98 GHz, with a maximum of 20.4 dBi.
Deciphering the Importance of Mineralogical Changes in the Neoproterozoic Epeiric Seas through the Sedimentary Succession of Tandilia System: A Brief Review
Authors: Gómez-Peral Lucía E. , Arrouy María Julia , Ferreyra Camila , Penzo Victoria , Poiré Daniel G.
Published: May 2024

The Neoproterozoic (>1160 to ~540 Ma) sedimentary record of the Tandilia System is reorganized into eight depositional sequences based on a detailed review of published sources and new lithological observations. The main compositional attributes compiled from the studied units were used to indicate changes in lithology regarding their origin. Epiclastic sections reveal supply and sources changes through the succession. Basement detritus was dominant during the deposition of the basal sequences turning drastically to a volcanic affinity dominance. The carbonate sections, dominated by intra-basinal components, were deposited in periods of rare or restricted detrital input. The older, described as a cap-dolostone, was related to bio-induced dolomite precipitation under a deglacial to interglacial context. The younger, a carbonate ramp, reveals to have been built by microbial activity adding high levels of oxygen to seawater correlated to a global oxygenation event. Compositional changes recorded in the shallow marine deposits of Tandilia could have been intricately linked to periods of tectonic and paleo-relief configurations, favoring the detrital supply into the basin, followed by relevant episodic biogeochemical changes. This study shows that the basinal-components progression was controlled by paleoclimate and paleoenvironments associated to the extensive interval between the rupture of the Rodinia to Gondwana paleogeographical framework.
Bioaccessibility of Metallic Nickel and Nickel Oxide Nanoparticles in Four Simulated Biological Fluids
Authors: Lyons-Darden Tara , Heim Katherine E. , Han Li , Haines Laura , Sayes Christie M. , Oller Adriana R.
Published: May 2024

Bioaccessibility of metals from substances and alloys is increasingly used as part of the assessment to predict potential toxicity. However, data are sparse on the metal bioaccessibility from nanoparticle (NP) size metal substances. This study examines nickel ion release from metallic nickel and nickel oxide micron particles (MPs) and NPs in simulated biological fluids at various timepoints including those relevant for specific routes of exposure. The results suggest that MPs of both metallic nickel and nickel oxide generally released more nickel ions in acidic simulated biological fluids (gastric and lysosomal) than NPs of the same substance, with the largest differences being for nickel oxide. In more neutral pH fluids (interstitial and perspiration), nickel metal NPs released more nickel ions than MPs, with nickel oxide results showing a higher release for MPs in interstitial fluid yet a lower release in perspiration fluid. Various experimental factors related to the particle, fluid, and extraction duration were identified that can have an impact on the particle dissolution and release of nickel ions. Overall, the results suggest that based on nickel release alone, nickel NPs are not inherently more hazardous than nickel MPs. Moreover, analyses should be performed on a case-by-case basis with consideration of various experimental factors and correlation with in vivo data.
Novel Highly Efficient Buried Gratings for Selective Coupling of SPP Waves onto Single Interfaces
Authors: Nabizada Arif , Tari Hamed , Bile Alessandro , Fazio Eugenio
Published: May 2024

Diffraction gratings have always been used to effectively couple optical radiation within integrated waveguides. This is also valid for plasmonic structures that support Surface Plasmon Polariton (SPP) waves. Traditional gratings usually excite SPP waves at the interface where they are located or, for thin metal nanostrips, at both interfaces. But reducing the thickness of the metal layer in the presence of a grating has the handicap of increasing the tunnelling of light towards the substrate, which means higher losses and reduced coupling efficiency. In this paper, we design and optimize novel gratings buried within the metallic thin films for selective coupling of SPP waves onto individual interfaces. Compared with traditional superficial gratings, the novel buried ones demonstrate higher efficiency and much lower residual tunnelling of light through the coupling structures.
Controlling Thermoelectric Properties of Laser-Induced Graphene on Polyimide
Authors: Kincal Cem , Solak Nuri
Published: May 2024

In the field of wearable thermoelectric generators, graphene-based materials have attracted attention as suitable candidates due to their low material costs and tunable electronic properties. However, their high thermal conductivity poses significant challenges. Low thermal conductivity due to porous structure of the laser-induced graphene, combined with its affordability and scalability, positions it as a promising candidate for thermoelectric applications. In this study, thermoelectric properties of the laser-induced graphene (LIG) on polyimide and their dependence on structural modifications of LIG were investigated. Furthermore, it was shown that increasing the laser scribing power on polyimide results in larger graphene flakes and a higher degree of graphitization. Electrical conductivity measurements indicated an increase with increasing laser power, due to a higher degree of graphitization, which enhances charge carrier mobility. Our findings reveal that LIG exhibits p-type semiconducting behavior, characterized by a positive Seebeck coefficient. It was shown that increasing laser power increased the Seebeck coefficient and electrical conductivity simultaneously, which is attributed to a charge carrier energy filtering effect arising from structures occurred on the graphene flakes. Moreover, the porous structure of LIG contributes to its relatively low thermal conductivity, ranging between 0.6 W/m·K and 0.85 W/m·K, which enhances the thermoelectric performance of LIG. It has been observed that with increasing laser power, the figure of merit for laser-induced graphene can be enhanced by nearly 10 times, which holds promising applications for laser-induced graphene due to the tunability of its thermoelectric performance by changing laser parameters.
Novel High-Entropy FeCoNiMoZn-Layered Hydroxide as an Efficient Electrocatalyst for the Oxygen Evolution Reaction
Authors: Cheng Zhihao , Han Xin , Han Liying , Zhang Jinfeng , Liu Jie , Wu Zhong , Zhong Cheng
Published: May 2024

The exploration of catalysts for the oxygen evolution reaction (OER) with high activity and acceptable price is essential for water splitting to hydrogen generation. High-entropy materials (HEMs) have aroused increasing interest in the field of electrocatalysis due to their unusual physicochemical properties. In this work, we reported a novel FeCoNiMoZn-OH high entropy hydroxide (HEH)/nickel foam (NF) synthesized by a facile pulsed electrochemical deposition method at room temperature. The FeCoNiMoZn-OH HEH displays a 3D porous nanosheet morphology and polycrystalline structure, which exhibits extraordinary OER activity in alkaline media, including much lower overpotential (248 mV at 10 mA cm−2) and Tafel slope (30 mV dec−1). Furthermore, FeCoNiMoZn-OH HEH demonstrates excellent OER catalytic stability. The enhanced catalytic performance of the FeCoNiMoZn-OH HEH primarily contributed to the porous morphology and the positive synergistic effect between Mo and Zn. This work provides a novel insight into the design of HEMs in catalytic application.
Nanoparticle-Modified 3D-Printed Denture Base Resins: Influence of Denture Cleansers on the Color Stability and Surface Roughness In Vitro
Authors: Gad Mohammed M. , Khattar Abdulrahman , Alramadan Doha M. , Al Dawood Zainab H. , Al Shehab Sujood S. , Al Zaher Rabab H. , Alzain Layal Osama , Khan Soban Q. , Abdelfattah Mohamed Y.
Published: May 2024

This study aimed to evaluate the influence of denture cleansers on the color, stability, and surface roughness of three-dimensional (3D)-printed denture base resins modified with zirconium dioxide nanoparticles (nano-ZrO2). A total of 440 specimens were fabricated using one heat-polymerized resin, and two 3D-printed resins (NextDent and ASIGA). According to the nano-ZrO2 content, the specimens for each resin were divided into five groups (0%, 0.5%wt, 1%wt, 3%wt, and 5%wt). Each concentration was divided into four subgroups (n = 10) based on the immersion solution (distilled water, sodium hypochlorite, Corega, and Fittydent) and immersion duration (360 and 720 days). The color changes (∆E00) and surface roughness (Ra, µm) of each specimen were measured at different time intervals (base line, 360 days, 720 days) using a spectrophotometer and a non-contact profilometer, respectively. The results were statistically analyzed using ANOVA and a post hoc Tukey’s test (α = 0.05). Sodium hypochlorite showed the highest significant color change of all the denture base resins (p < 0.001). The average value of ΔE00 for sodium hypochlorite was significantly higher than the values for the other solutions (Fittydent, Corega, and water) (p < 0.001). Color stability was significantly affected by immersion time for all types of solutions except Corega (p < 0.001). All of the tested immersion solutions (distilled water, sodium hypochlorite, Corega, and Fittydent) showed a significant increase in the surface roughness of all the denture base resins (p < 0.05). Surface roughness was substantially increased by immersion time for all types of solution except Fittydent (p < 0.001). Denture cleansers can result in substantial color change and affect the surface roughness of unmodified and nanoparticle-modified denture base resins. Therefore, the selection of denture cleanser and appropriate types of material is critical for denture longevity.
Carbon Nanofiber Membranes Loaded with MXene@g-C3N4: Preparation and Photocatalytic Property
Authors: Lou Ching-Wen , Xie Meng-Meng , Yang Yan-Dong , Wang Hong-Yang , Wang Zhi-Ke , Zhang Lu , Hsieh Chien-Teng , Liu Li-Yan , Lin Mei-Chen , Li Ting-Ting
Published: May 2024

In this study, a Ti3C2 MXene@g-C3N4 composite powder (TM-CN) was prepared by the ultrasonic self-assembly method and then loaded onto a carbon nanofiber membrane by the self-assembly properties of MXene for the treatment of organic pollutants in wastewater. The characterization of the TM-CN and the C-TM-CN was conducted via X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectrometer (FTIR) to ascertain the successful modification. The organic dye degradation experiments demonstrated that introducing an appropriate amount of Ti3C2 MXene resulted in the complete degradation of RhB within 60 min, three times the photocatalytic efficiency of a pure g-C3N4. The C-TM-CN exhibited the stable and outstanding photocatalytic degradation of the RhB solution over a wide range of pH values, indicating the characteristics of the photodegradation of organic pollutants in a wide range of aqueous environments. Furthermore, the results of the cyclic degradation experiments demonstrated that the C-TM-CN composite film maintained a degradation efficiency of over 85% after five cycles, thereby confirming a notable improvement in its cyclic stability. Consequently, the C-TM-CN composite film exhibits excellent photocatalytic performance and is readily recyclable, making it an auspicious eco-friendly material in water environment remediation.
Abridging the CMOS Technology II
Authors: Wong Hei
Published: May 2024

As silicon CMOS devices approach their physical and technological miniaturization limits, Moore’s Law is expected to persist for several more cycles, thanks to innovative, more compact layout structures [...]