bluuebunny/crossref_metadata_2025 huggingface dataset:
Dimensions of suffering and the need for palliative care: experiences and expectations of patients living with cancer and diabetes and their caregivers in Mexico – a qualitative study
Authors: Doubova Svetlana V , Bhadelia Afsan , Pérez-Moran Diana , Martinez-Vega Ingrid Patricia , García-Cervantes Nancy , Knaul Felicia
Published: December 2023

Objectives

Over 40 million people in low-income and middle-income countries (LMICs) experience serious health-related suffering (SHS) annually and require palliative care. Patient and caregiver experiences of SHS in LMICs are understudied despite their importance in guiding palliative care provision. Diabetes and cancer are the second-leading and third-leading causes of death in Mexico, causing a significant SHS burden on patients, families and health systems. This study examines SHS and palliative care from the point of view of patients with cancer and diabetes and their caregivers.

Design

A qualitative descriptive study based on in-depth telephone interviews was conducted between August 2021 and February 2022. Data were analysed through inductive thematic analysis.

Participants

Overall, 20 patients with end-stage cancer, 13 patients with diabetes and 35 family caregivers were interviewed individually.

Setting

Participants were recruited from two family medicine clinics and a pain clinic in Mexico City.

Results

Seven themes emerged: (1) suffering as a multifaceted phenomenon, (2) diversity in perceptions of suffering, (3) different coping strategies, (4) need and perceived importance of relief from suffering, (5) barriers to accessing services to relieve suffering, (6) demand for the health sector’s active and humane role in addressing suffering and (7) preferences and need for comprehensive care for relief from suffering. The primary coping strategies included family companionship, protective buffering and faith-based support. Participants lacked knowledge of palliative care. They expressed the importance of relief from suffering, viewing it as the health sector’s responsibility and requesting more humane, personalised care and access to medicines and pain clinics.

Conclusions

The multifaceted nature of SHS highlights the health system’s responsibility to provide high-quality palliative care. Policies to enhance access to palliative care should integrate it into primary care, redesigning services towards patient and caregiver biopsychosocial and spiritual needs and ensuring access to medicines and competent health personnel.
Evaluation of antimicrobial photodynamic therapy and minimal intervention associated with deproteinisation in permanent teeth with molar incisor hypomineralisation: study protocol for a clinical, controlled, blinded trial
Authors: Mandetta Amanda Rafaelly Honório , Bortoletto Carolina Carvalho , Sobral Ana Paula Taboada , Gonçalves Marcela Letícia Leal , Motta Lara Jansiski , Horliana Anna Carolina Ratto Tempestini , Ferrari Raquel Agnelli Mesquita , Prates Renato Araujo , Deana Alessandro Melo , Cordeiro Rita de Cássia Loiola , Pinto Lourdes Aparecida Martins dos Santo , Fernandes Kristianne Porta Santos , Bussadori Sandra Kalil
Published: December 2023

Introduction

Molar incisor hypomineralisation (MIH) is a qualitative defect of enamel development that occurs in the mineralisation phase. MIH affects one or more permanent molars and, occasionally, permanent incisors. The aim of the proposed study is to evaluate the clinical effect of antimicrobial photodynamic therapy (aPDT) on permanent teeth with MIH through decontamination and sensitivity control.

Methods and analysis

Patients from 8 to 12 years of age with permanent molars will be randomly allocated to three groups. Group 1: selective chemical–mechanical removal of carious dentinal tissue around the walls of the cavity with Papacárie Duo and a curette followed by the application of aPDT and deproteinisation with Papacárie Duo; group 2: selective removal of carious dentinal tissue around the walls of the cavity with a curette, followed by the application of aPDT and deproteinisation with a 5% sodium hypochlorite solution; group 3: selective removal of carious dentinal tissue using a curette. The selected teeth must have a carious lesion in the dentin and posteruptive enamel breakdown on one or more surfaces with an indication for clinical restorative treatment. The teeth will subsequently be restored using a mixed technique with resin-modified glass ionomer cement and bulk-fill composite resin. The data will be submitted to descriptive statistical analysis. Associations with age and sex will be tested using either the χ2test or Fisher’s exact test. Pearson’s correlation coefficients will be calculated to determine the strength of correlations between variables. Comparisons of the microbiological results (colony-forming units) will be performed using analysis of variance and the Kruskal-Wallis test. Kaplan-Meier survival analysis will be performed to assess the performance of the restorations.

Ethics and dissemination

This protocol has been approved by the Human Research Ethics Committee of Nove de Julho University (certificate number: 61027522.0.0000.5511/approval date: 23 August 2022). The findings will be published in a peer-reviewed journal.

Trial registration number

NCT05443035.
Patient experience of a virtual reality calm room in a psychiatric inpatient care setting in Sweden: a qualitative study with inpatients
Authors: Ilioudi Maria , Wallström Sara , Steingrimsson Steinn , Lindner Philip , Thunström Almira Osmanovic , Ali Lilas
Published: December 2023

Objective

Calm rooms have been developed and implemented in psychiatric inpatient care settings to offer patients a dedicated space for relaxation in a convenient and safe environment. Recent technology developments have enabled virtual reality (VR) equivalents of calm rooms that can be feasibly deployed in psychiatric care settings. While research has shown VR environments to be efficacious in inducing relaxation, little is known how these virtual calm rooms are perceived by patients. The aim of this study was to elucidate patient experiences of using a VR calm room in a psychiatric inpatient setting.

Design

Qualitative interview study. Semi-structured interviews were analysed using qualitive inductive content analysis, which focuses on the interpretation of texts for making replicable and valid inferences.

Setting

Swedish hospital psychiatric inpatient care setting with a wireless, three degrees-of-freedom VR head-mounted display running a calm room application simulating nature environment.

Participants

20 adult patients (12 women) with bipolar disorder (n=18) or unipolar depression (n=2).

Results

Participants experienced the use of the VR calm room as having a positive impact on them, inducing awareness, calmness and well-being. They were thankful to be offered a non-pharmacological alternative for anxiety relief. Participants also expressed that they had some concerns about how they would react emotionally before using the VR device. However, after use, they highlighted that their overall experience was positive. They also expressed that they could see potential for further development of VR technology in psychiatric care.

Conclusions

VR technology has the potential to solve pressing logistic issues in offering calm rooms in psychiatric inpatient care. VR calm rooms appear to be appreciated by psychiatric inpatients, who value their accessibility, convenience and variety of modalities offered. Participants perceived an increase in their well-being after use.
First-line treatment with durvalumab plus chemotherapy versus chemotherapy alone for metastatic non-small-cell lung cancer in the USA: a cost-effectiveness analysis
Authors: Zheng Zhiwei , Fang Ling , Cai Hongfu
Published: December 2023

Objective

The objective of this study was to evaluate the cost-effectiveness of durvalumab in combination with chemotherapy compared with chemotherapy alone as first-line therapy for metastatic non-small-cell lung cancer (NSCLC) from the perspective of the US payer.

Methods

Based on the POSEIDON clinical trial, a partition survival model was developed to compare the cost-effectiveness of durvalumab in combination with chemotherapy versus chemotherapy alone for the first-line treatment of metastatic NSCLC. The model’s primary outcomes were costs, life years (LYs), quality-adjusted LYs (QALYs) and the incremental cost-effectiveness ratio (ICER). The analysis only considered direct medical costs, and health utility value was determined using published literature. The robustness of the model was tested by probabilistic sensitivity analyses.

Results

The combination therapy of durvalumab and chemotherapy improved survival by 0.713 QALYs at an incremental cost of $64 104.638 compared with chemotherapy alone, resulting in an ICER of $89 908.328 per QALY gained from the US payer perspective. The combination therapy had a 92.3% probability of being cost-effective at a willingness-to-pay threshold of $150 000 per QALY based on incremental net health benefits. Sensitivity analyses confirmed the model’s consistency, and none of the parameters significantly influenced the findings.

Conclusion

Durvalumab in combination with chemotherapy represents a more cost-effective strategy for first-line therapy in patients with metastatic NSCLC in the USA compared with chemotherapy alone.
Implementing a complex mental health intervention in occupational settings: process evaluation of the MENTUPP pilot study
Authors: Tsantila Fotini , Coppens Evelien , De Witte Hans , Arensman Ella , Aust Birgit , Pashoja Arlinda Cerga , Corcoran Paul , Cully Grace , De Winter Lars , Doukani Asmae , Dushaj Arilda , Fanaj Naim , Griffin Eve , Hogg Bridget , Holland Carolyn , Leduc Caleb , Leduc Mallorie , Mathieu Sharna , Maxwell Margaret , Ni Dhalaigh Doireann , O' Brien Cliodhna , Reich Hanna , Ditta Tóth Mónika , van Weeghel Jaap , Van Audenhove Chantal
Published: December 2023

Background

According to the Medical Research Council (MRC) framework, the theorisation of how multilevel, multicomponent interventions work and the understanding of their interaction with their implementation context are necessary to be able to evaluate them beyond their complexity. More research is needed to provide good examples following this approach in order to produce evidence-based information on implementation practices.

Objectives

This article reports on the results of the process evaluation of a complex mental health intervention in small and medium enterprises (SMEs) tested through a pilot study. The overarching aim is to contribute to the evidence base related to the recruitment, engagement and implementation strategies of applied mental health interventions in the workplace.

Method

The Mental Health Promotion and Intervention in Occupational Settings (MENTUPP) intervention was pilot tested in 25 SMEs in three work sectors and nine countries. The evaluation strategy of the pilot test relied on a mixed-methods approach combining qualitative and quantitative research methods. The process evaluation was inspired by the RE-AIM framework and the taxonomy of implementation outcomes suggested by Proctor and colleagues and focused on seven dimensions: reach, adoption, implementation, acceptability, appropriateness, feasibility and maintenance.

Results

Factors facilitating implementation included the variety of the provided materials, the support provided by the research officers (ROs) and the existence of a structured plan for implementation, among others. Main barriers to implementation were the difficulty of talking about mental health, familiarisation with technology, difficulty in fitting the intervention into the daily routine and restrictions caused by COVID-19.

Conclusions

The results will be used to optimise the MENTUPP intervention and the theoretical framework that we developed to evaluate the causal mechanisms underlying MENTUPP. Conducting this systematic and comprehensive process evaluation contributes to the enhancement of the evidence base related to mental health interventions in the workplace and it can be used as a guide to overcome their contextual complexity.

Trial registration number

ISRCTN14582090.
Effects of socioeconomic status on patient-reported outcome after surgically treated trigger finger: a retrospective national registry-based study
Authors: Lesand Lovisa , Dahlin Lars B , Rydberg Mattias , Zimmerman Malin
Published: December 2023

Objectives

To investigate if socioeconomic status impacts patient-reported outcomes after a surgically treated trigger finger (TF).

Design and setting

Data on patients with TF treated with surgery were collected from the Swedish National Quality Registry of Hand Surgery (HAKIR) 2010–2019 with an evaluation of symptoms and disability before surgery and at 3 and 12 months after surgery, using the short version of the Disabilities of Arm, Shoulder and Hand (QuickDASH) questionnaire.

Data from HAKIR and the Swedish National Diabetes Registry (ndr.nu) were combined with socioeconomic data from Statistics Sweden (scb.sc), analysing the impact of marital status, education level, income, occupation, sickness benefits, days of unemployment, social assistance and migrant status on the outcome by a linear regression model.

Participants

In total, 5477 patients were operated on for primary TF during the study period, of whom 21% had diabetes, with a response rate of 35% preoperatively, 26% at 3 months and 25% at 12 months.

Results

At all time points, being born in Sweden (preoperatively B-coefficient: −9.74 (95% CI −13.38 to −6.11), 3 months postoperatively −9.80 (95% CI −13.82 to −5.78) and 12 months postoperatively −8.28 (95% CI −12.51 to −4.05); all p<0.001) and high earnings (preoperatively −7.81 (95% CI −11.50 to −4.12), 3 months postoperatively −9.35 (95% CI −13.30 to −5.40) and 12 months postoperatively −10.25 (95% CI −14.37 to −6.13); all p<0.0001) predicted lower QuickDASH scores (ie, fewer symptoms and disability) in the linear regression models. More sick leave during the surgery year predicted higher QuickDASH scores (preoperatively 5.77 (95% CI 3.28 to 8.25; p<0.001), 3 months postoperatively 4.40 (95% CI 1.59 to 7.22; p<0.001) and 12 months postoperatively 4.38 (95% CI 1.35 to 7.40; p=0.005)). No socioeconomic factors impacted the change in QuickDASH score from preoperative to 12 months postoperatively in the fully adjusted model.

Conclusion

Individuals with low earnings, high sick leave the same year as the surgery and those born outside of Sweden reported more symptoms both before and after surgery, but the relative improvement was not affected by socioeconomic factors.
PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery
Authors: Hackett Claire , Denehy Linda , Kruger Peter , Ripley Nina , Reid Natasha , Smithers B Mark , Walker Rachel M , Hope Louise , Boden Ianthe
Published: December 2023

Introduction

Few clinical trials have investigated physiotherapy interventions to treat hypoxaemia following abdominal surgery. The objective of this study is to determine the feasibility and safety of conducting a clinical trial of physiotherapist-led non-invasive ventilation (NIV).

Methods and analysis

This single-centre, 50-patient, parallel-group, assessor blinded, pilot feasibility randomised controlled trial with concealed allocation will enrol spontaneously ventilating adults with hypoxaemia within 72 hours of major abdominal surgery. Participants will receive either (1) usual care physiotherapy of a single education session (talk), daily walking of 10–15 min (walk) and four sessions of coached deep breathing and coughing (breathe) or (2) usual care physiotherapy plus four 30 min sessions of physiotherapist-led NIV delivered over 2 postoperative days. Primary feasibility and safety outcome measures are; number of eligible patients recruited per week, total time of NIV treatment delivered, acceptability of treatments to patients and clinicians and incidence of adverse events. Secondary feasibility outcomes include measures of recruitment and treatment adherence. Exploratory outcome measures include change in respiratory parameters, postoperative pulmonary complications, length of hospital stay, health-related quality of life, postoperative activity levels and mortality.

Ethics and dissemination

Ethics approval has been obtained from the relevant institution. Results will be published to inform future research.

Trial registration number

ACTRN12622000839707.
Non-pharmacological fatigue interventions for patients with a primary brain tumour: a scoping review protocol
Authors: Simms-Moore Rachael , Dures Emma , Barua Neil , Cramp Fiona
Published: December 2023

Introduction

Fatigue is the most prevalent symptom for patients with a primary brain tumour (PBT), significantly reducing quality of life and limiting daily activities. Currently, there are limited options for managing cancer-related fatigue (CRF) in patients with a PBT, using non-pharmacological methods. The objective of this scoping review is to identify current and emerging evidence in relation to non-pharmacological CRF interventions for patients with a PBT.

Methods and analysis

Electronic databases OVID and EBSCO platforms: MEDLINE, EMBASE and CINAHL will be searched. In addition, PROSPERO, The Cochrane Library and ISI Web of Science will be searched. Trials registries CENTRAL and the International Clinical Trials Registry platform will also be searched for ongoing research. Inclusion criteria: studies from 2006 onwards, primary research on non-pharmacological interventions in patients with a PBT (>18 years). A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram will be utilised to summarise the screening process and results.

Quantitative data will be analysed descriptively, while content analysis will be used for qualitative data.

Findings will map the existing and emerging evidence on non-pharmacological interventions for CRF in patients with PBTs. This will provide insights into the extent and nature of the evidence in this evolving field, identifying gaps in knowledge and research priorities, and guide further investigations in this area.

Ethics and dissemination

Ethical approval is not required for this scoping review. Findings will be disseminated via relevant peer-reviewed journals, PhD thesis, conference presentations, and shared with relevant charities and health professionals.
Exploring mobility data for enhancing HIV care engagement in Black/African American and Hispanic/Latinx individuals: a longitudinal observational study protocol
Authors: Hassani Maryam , De Haro Cristina , Flores Lidia , Emish Mohamed , Kim Seungjun , Kelani Zeyad , Ugarte Dominic Arjuna , Hightow-Weidman Lisa , Castel Amanda , Li Xiaoming , Theall Katherine P , Young Sean
Published: December 2023

Introduction

Increasing engagement in HIV care among people living with HIV, especially those from Black/African American and Hispanic/Latinx communities, is an urgent need. Mobility data that measure individuals’ movements over time in combination with sociostructural data (eg, crime, census) can potentially identify barriers and facilitators to HIV care engagement and can enhance public health surveillance and inform interventions.

Methods and analysis

The proposed work is a longitudinal observational cohort study aiming to enrol 400 Black/African American and Hispanic/Latinx individuals living with HIV in areas of the USA with high prevalence rates of HIV. Each participant will be asked to share at least 14 consecutive days of mobility data per month through the study app for 1 year and complete surveys at five time points (baseline, 3, 6, 9 and 12 months). The study app will collect Global Positioning System (GPS) data. These GPS data will be merged with other data sets containing information related to HIV care facilities, other healthcare, business and service locations, and sociostructural data. Machine learning and deep learning models will be used for data analysis to identify contextual predictors of HIV care engagement. The study includes interviews with stakeholders to evaluate the implementation and ethical concerns of using mobility data to increase engagement in HIV care. We seek to study the relationship between mobility patterns and HIV care engagement.

Ethics and dissemination

Ethical approval has been obtained from the Institutional Review Board of the University of California, Irvine (#20205923). Collected data will be deidentified and securely stored. Dissemination of findings will be done through presentations, posters and research papers while collaborating with other research teams.
Potential energy surface and quantum dynamics calculation of SH2− (2A′) based on ab initio scaled external correlation correction
Authors: Ma Hongyu , Gu Ning
Published: December 2023

An accurate interatomic potential energy surface for ground state of SH2− is reported at the multireference configuration interaction level of theory using aug–cc–pVQZ basis set. The calculated ab initio energy points are utilized, after semi-empirically correcting the dynamical correlation by the many-body expansion-scaled external correlation method. To verify the accuracy of the potential energy surface, molecular reaction dynamics, including the relationship between reaction probability and collision energy, thermal rate constant, and integral scattering cross section are calculated by using the quantum time-dependent wave packet method. The final results show that our potential energy surface is accurate and the molecular reaction dynamics results are satisfactory, and the accurate potential energy surface and its dynamics results can also lay a foundation for the future experimental research of SH−-containing molecules.
Impact of Digital Transformation on Accelerating Enterprise Innovation—Evidence from the Data of Chinese Listed Companies
Authors: Liu Jiqiong , Liu Chunyan , Feng Shuai
Published: December 2023

Under the background of the rapid development of digital economy, this paper empirically analyzes the impact of digital transformation on enterprise innovation and selects the panel data of China’s Shanghai and Shenzhen A-share listed companies from 2013 to 2021 as the research objective is to study the impact of digital transformation on enterprise innovation from theoretical and empirical perspectives. First, we find that digital transformation accelerates enterprise innovation, a conclusion that has been validated through robustness testing. Second, digital transformation impacts enterprise innovation by enhancing productivity and information transparency. Third, financing constraints and financial redundancy play distinct regulatory roles in the process. Fourth, heterogeneity analysis finds that the role of digital transformation in promoting enterprise innovation has different effects in state-owned and non-state-owned enterprises, high-tech and non-high-tech enterprises, and enterprises with different life cycles. Finally, the functional analysis suggests that further investigation is needed to determine whether digital transformation can significantly promote the sustainable development of enterprises through innovation while also recognizing that this function may have a lag effect. Overall, this study contributes to a deeper understanding of digital transformation and innovation-driven practices and encourages more significant integration of the real and digital economies.
UPLC-Q-Exactive-MS Combined with Network Pharmacology to Explore the Antitumor Effect of Polygonatum sibiricum Leaf Tea
Authors: Chen Jie , Xia Jie , Yin Feng , Yu Jiani , Huo Jinfeng , Shi Yingjiao , Han Ruilian , Zeng Zhongda , Zhang Xiaodan
Published: December 2023

Background. Currently, the substance basis and function of Polygonatum sibiricum leaf remain unknown. Objective. This study aims to investigate the antitumor mechanism of P. sibiricum leaf tea through network pharmacology. Methods. Ultraperformance liquid chromatography quadrupole exactive mass spectrometry (UPLC-Q-Exactive-MS) was employed to analyze the chemical components in the extract of P. sibiricum leaf tea. Compounds were screened using the PubChem database and SwissADME platform. The compound targets were identified using the Swiss Target Prediction database, while the disease targets were obtained from the GeneCards database. Subsequently, a compound-protein interaction network was constructed, and KEGG pathway enrichment analysis was performed to elucidate the antitumor activity pathway of P. sibiricum leaf tea. Molecular docking verification was carried out as well. Results. From the extract of P. sibiricum leaf tea, a total of fifty-six components were screened, including 27 active components. Seventy-two corresponding targets closely associated with the antitumor activity of P. sibiricum leaf tea were identified. By constructing a compound-target-pathway network diagram, three key compounds (pubescenol, avenanthramide E, and 13-cis-acitretin) and eleven key targets (AKT1, EGFR, CASP3, CCND1, MTOR, MMP9, ERBB2, BCL2L1, MAPK1, PPARG, and PIK3CA) were determined. Additionally, KEGG pathway analysis identified 30 antitumor related pathways. The results of molecular docking between the three key compounds and the top three targets (AKT1, EGFR, and CASP3) were consistent with the findings of network pharmacology. Conclusion. This study highlights the distinctive features of P. sibiricum leaf tea extract, which possesses multiple components, targets, and pathways. It successfully identifies the active components of P. sibiricum leaf tea that exhibit antitumor properties, along with their potential mechanisms of action. These findings offer valuable insights and inspiration for further research on novel mechanisms of action.
Cerebellar Compression by Giant Extracanalicular Osteoma with Central Cholesterol Granuloma
Authors: Smith Caroline F. , Massey Conner J. , Mann Scott E.
Published: December 2023

Temporal bone osteomas comprise 0.1–1% of benign tumors involving the skull, the majority of which arise in the external auditory canal. More rarely, they can arise from the mastoid portion of the temporal bone. These generally present as a slow growing skull base lesion that can cause cosmetic deformity, headache, and/or hearing loss. Here, we report a case of extracanalicular mastoid osteoma uniquely presenting with posterior fossa and cerebellar compression with associated dizziness and imbalance.
The Determinants of Beef Cattle Market Participation on Beef Cattle Producers’ Welfare: A Case Study of West Shewa Zone, Oromia Region, Ethiopia
Authors: Willy Bultossa Terefe , Beyene Amsalu Bedemo , Amare Daniel Masresha
Published: December 2023

Due to their ability to produce meat, milk, leather, glue, gelatin, and other products that people may utilize, beef cattle are domesticated. Beef cattle production and marketing play a vital role in the growth and development of the globe and the African economy. Ethiopia has great potential for livestock population in Africa and in the world but earns less from beef cattle production and marketing. Ethiopian farmers are reluctant to beef cattle market participation. Their reluctant to participate in beef cattle marketing causes lack of beef cattle products in the market and causes high prices for beef cattle and its products. The research objective was to analyze the impact of beef cattle market participation on the welfare of beef cattle smallholder farmers in Ethiopia. The primary data come from 400 randomly selected beef cattle farmers involved in beef cattle production and marketing and actors. Descriptive statistics and inferential statistics propensity score matching (PSM) model have used to analyze the collected data. The data analysis result indicated that smallholder beef cattle farmers participating in beef cattle marketing and farmers’ annual per capita consumption expenditure (economic welfare) increased by 84% more than the nonbeef cattle market participants. We assume this is a first result and investigation in the study area. The research study is important for farmers, policymakers, researchers, and the academia in general. Providing education and training, promoting the participation of more women in beef cattle marketing, and promoting and encouraging more full-time beef cattle farmers are suggested recommendations.
Supplementary Methods and Figure Legends 1-2 from RETRACTED: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation
Authors: Datta Jharna , Ghoshal Kalpana , Denny William A. , Gamage Swarna A. , Brooke Darby G. , Phiasivongsa Pasit , Redkar Sanjeev , Jacob Samson T.
Published: December 2023

Supplementary Methods and Figure Legends 1-2 from RETRACTED: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation
Supplementary Methods, Table 1, Figures 1-8 from RETRACTED: Loss of Metallothionein Predisposes Mice to Diethylnitrosamine-Induced Hepatocarcinogenesis by Activating NF-κB Target Genes
Authors: Majumder Sarmila , Roy Satavisha , Kaffenberger Thomas , Wang Bo , Costinean Stefan , Frankel Wendy , Bratasz Anna , Kuppusamy Periannan , Hai Tsonwin , Ghoshal Kalpana , Jacob Samson T.
Published: December 2023

Supplementary Methods, Table 1, Figures 1-8 from RETRACTED: Loss of Metallothionein Predisposes Mice to Diethylnitrosamine-Induced Hepatocarcinogenesis by Activating NF-κB Target Genes
Supplementary Materials and Methods from FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation
Authors: Ouyang Yi , Ou Ziwei , Zhong Wenlong , Yang Jin , Fu Sha , Ouyang Nengtai , Chen Junyu , Xu Longhao , Wu Daqin , Qian Junan , Lin Yi , Lin Tianxin , Huang Jian
Published: December 2023

Supplementary Materials and Methods
Table S4 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

qPCR probes utilized in this study
Table S3 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Antibodies/Dyes utilized in this study
Table S2 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Compounds/Inhibitors utilized in this study
Table S1 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Cell lines utilized in this study
Figure S3 from Fructose-Induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
Authors: Cui Yanfen , Tian Jianfei , Wang Zhaosong , Guo Hui , Zhang He , Wang Zhiyong , Liu Hui , Song Weijie , Liu Liming , Tian Ruinan , Zuo Xiaoyan , Ren Sixin , Niu Ruifang , Zhang Fei
Published: December 2023

Figure S3
Figure S7 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Supplementary Figure 7
Figure S6 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Supplementary Figure 6
Figure S5 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Supplementary Figure 5
Supplementary Data from CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non–Small Cell Lung Cancer
Authors: Prahallad Anirudh , Weiss Andreas , Voshol Hans , Kerr Grainne , Sprouffske Kathleen , Yuan Tina , Ruddy David , Meistertzheim Morgane , Kazic-Legueux Malika , Kottarathil Tina , Piquet Michelle , Cao Yichen , Martinuzzi-Duboc Laetitia , Buhles Alexandra , Adler Flavia , Mannino Salvatore , Tordella Luca , Sansregret Laurent , Maira Sauveur-Michel , Graus Porta Diana , Fedele Carmine , Brachmann Saskia M.
Published: December 2023

Supplementary methods, tables and figures
Figure S2 from TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards A. Cole , Stalnecker Clint A. , Jean Morales Alexis , Taylor Khalilah E. , Klomp Jennifer E. , Klomp Jeffrey A. , Waters Andrew M. , Sudhakar Niranjan , Hallin Jill , Tang Tracy T. , Olson Peter , Post Leonard , Christensen James G. , Cox Adrienne D. , Der Channing J.
Published: December 2023

Supplementary Figure 2
Table S2 from Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma
Authors: Wu Yige , Chen Siqi , Yang Xiaolu , Sato Kazuhito , Lal Preet , Wang Yuefan , Shinkle Andrew T. , Wendl Michael C. , Primeau Tina M. , Zhao Yanyan , Gould Alanna , Sun Hua , Mudd Jacqueline L. , Hoog Jeremy , Mashl R. Jay , Wyczalkowski Matthew A. , Mo Chia-Kuei , Liu Ruiyang , Herndon John M. , Davies Sherri R. , Liu Di , Ding Xi , Evrard Yvonne A. , Welm Bryan E. , Lum David , Koh Mei Yee , Welm Alana L. , Chuang Jeffrey H. , Moscow Jeffrey A. , Meric-Bernstam Funda , Govindan Ramaswamy , Li Shunqiang , Hsieh James , Fields Ryan C. , Lim Kian-Huat , Ma Cynthia X. , Zhang Hui , Ding Li , Chen Feng
Published: December 2023

Somatic mutations and copy number alterations for the tumors
Table S2. Ingenuity Pathway Analysis of LILRB3 antibody treated U937 cells from LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy
Authors: Mai Sunny , Hodges Alan , Chen Hui-Ming , Zhang Jilu , Wang Yi-Ling , Liu Yongbin , Nakatsu Fumiko , Wang Xiaoxuan , Fang Jing , Xu Yitian , Davidov Vitaliy , Kang Kyeongah , Pingali Sai Ravi , Ganguly Siddhartha , Suzuki Masataka , Konopleva Marina , Prinzing Brooke , Zu Youli , Gottschalk Stephen , Lu Yong , Chen Shu-Hsia , Pan Ping-Ying
Published: December 2023

Pathway analysis of LILRB3 antibody treated U937 cells.
Supplementary Table S4 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: December 2023

Supplementary Table S4
MaGeCK analysis of MRTX-849/TNO155 CRISPR/Cas9 screens of NSCLC cell lines
Supplementary Table S3 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: December 2023

Supplementary Table S3
RNA-seq analysis of H2030 and H2122 cells treated with MRTX-849 or vehicle for 48 hr
Supplementary Table S11 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: December 2023

Supplementary Table S11
Differential gene expression analysis of scRNA-seq data from tumor cluster in patient #2349 (MRTX-849/TNO155-resistant) vs patient #1566 (control, KRASG12V tumor)
Data from RETRACTED: Loss of Metallothionein Predisposes Mice to Diethylnitrosamine-Induced Hepatocarcinogenesis by Activating NF-κB Target Genes
Authors: Majumder Sarmila , Roy Satavisha , Kaffenberger Thomas , Wang Bo , Costinean Stefan , Frankel Wendy , Bratasz Anna , Kuppusamy Periannan , Hai Tsonwin , Ghoshal Kalpana , Jacob Samson T.
Published: December 2023

Abstract
Metallothioneins (MT) are potent scavengers of free radicals that are silenced in primary hepatocellular carcinomas (HCC) of human and rodent origin. To examine whether loss of MT promotes hepatocarcinogenesis, male Mt-1 and Mt-2 double knockout (MTKO) and wild-type (WT) mice were exposed to diethylnitrosamine (DEN) and induction of HCC was monitored at 23 and 33 weeks. The size and number of liver tumors, the ratio between liver and body weight, and liver damage were markedly elevated in the MTKO mice at both time points compared with the WT mice. At 23 weeks, MTKO mice developed HCC whereas WT mice developed only preneoplastic nodules suggesting that loss of MT accelerates hepatocarcinogenesis. MTKO tumors also exhibited higher superoxide anion levels. Although NF-κB activity increased in the liver nuclear extracts of both genotypes after DEN exposure, the complex formed in MTKO mice was predominantly p50/65 heterodimer (transcriptional activator) as opposed to p50 homodimer (transcriptional repressor) in WT mice. Phosphorylation of p65 at Ser276 causing its activation was also significantly augmented in DEN-exposed MTKO livers. NF-κB targets that include early growth response genes and proinflammatory cytokines were significantly upregulated in MTKO mice. Concurrently, there was a remarkable increase (∼100-fold) in Pai-1 expression; significant increase in c-Jun, c-Fos, c-Myc, Ets2, and ATF3 expressions; and growth factor signaling that probably contributed to the increased tumor growth in MTKO mice. Taken together, these results demonstrate that MTs protect mice from hepatocarcinogen-induced liver damage and carcinogenesis, underscoring their potential therapeutic application against hepatocellular cancer. Cancer Res; 70(24); 10265–76. ©2010 AACR.
Data from Super Enhancer–Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis
Authors: Su Tao , Zhang Nasha , Wang Teng , Zeng Jiajia , Li Wenwen , Han Linyu , Yang Ming
Published: December 2023

Abstract
Hepatocellular carcinoma (HCC) is one of the most lethal neoplasms and has a 5-year survival rate of only 18% in patients with metastatic diseases. Epigenetic modifiers and alterations, including histone modifications, long noncoding RNAs (lncRNA), RNA alternative splicing, and N6-methyladenosine (m6A) modification, are key regulators of HCC development, highlighting the importance of understanding the cross-talk between these biological processes. In the current study, we identified LINC01089 as a super enhancer (SE)–driven lncRNA that promotes epithelial–mesenchymal transition (EMT), migration, invasion, and metastasis of HCC cells in vivo and in vitro. The transcription factor E2F1 bound to a LINC01089 SE, promoting LINC01089 transcription and overexpression. LINC01089 interacted with heterogeneous nuclear ribonucleoprotein M (hnRNPM) and led to hnRNPM-mediated skipping of DIAPH3 exon 3. Knockdown of LINC01089 increased the inclusion of DIAPH3 exon 3, which contains an important m6A-modification site that is recognized by IGF2BP3 to increase DIAPH3 mRNA stability. Thus, LINC01089 loss increased DIAPH3 protein levels, which suppressed the ERK/Elk1/Snail axis and inhibited EMT of HCC cells. In conclusion, this study revealed cross-talk between different epigenetics modifiers and alterations that drives HCC progression and identified LINC01089 as a potential prognostic marker and therapeutic target for HCC.
Significance:
LINC01089 is a super enhancer–driven long noncoding RNA that induces ERK signaling and epithelial–mesenchymal transition by regulating DIAPH3 alternative splicing that blocks N6-methyladenosine–mediated mRNA stabilization, establishing an epigenetic network that promotes hepatocellular carcinoma metastasis.
Data from Fructose-Induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
Authors: Cui Yanfen , Tian Jianfei , Wang Zhaosong , Guo Hui , Zhang He , Wang Zhiyong , Liu Hui , Song Weijie , Liu Liming , Tian Ruinan , Zuo Xiaoyan , Ren Sixin , Niu Ruifang , Zhang Fei
Published: December 2023

Abstract
Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding of the mechanisms underlying the functions of fructose in cancer could facilitate the development of better treatment and prevention strategies. In this study, we investigated the functional association between fructose utilization and pancreatic ductal adenocarcinoma (PDAC) progression. Fructose could be taken up and metabolized by PDAC cells and provided an adaptive survival mechanism for PDAC cells under glucose-deficient conditions. GLUT5-mediated fructose metabolism maintained the survival, proliferation, and invasion capacities of PDAC cells in vivo and in vitro. Fructose metabolism not only provided ATP and biomass to PDAC cells but also conferred metabolic plasticity to the cells, making them more adaptable to the tumor microenvironment. Mechanistically, fructose activated the AMP-activated protein kinase (AMPK)–mTORC1 signaling pathway to inhibit glucose deficiency-induced autophagic cell death. Moreover, the fructose-specific transporter GLUT5 was highly expressed in PDAC tissues and was an independent marker of disease progression in patients with PDAC. These findings provide mechanistic insights into the role of fructose in promoting PDAC progression and offer potential strategies for targeting metabolism to treat PDAC.
Significance:
Fructose activates AMPK–mTORC1 signaling to inhibit autophagy-mediated cell death in pancreatic cancer cells caused by glucose deficiency, facilitating metabolic adaptation to the tumor microenvironment and supporting tumor growth.
Table 1 from Facts and Hopes on RAS Inhibitors and Cancer Immunotherapy
Authors: Boumelha Jesse , Molina-Arcas Miriam , Downward Julian
Published: December 2023

Clinical trials evaluating the combination of KRAS–G12C inhibitors with immune checkpoint inhibitors.
Supplementary Table S2 from A Pilot Study Omitting Radiation in the Treatment of Children with Newly Diagnosed Wnt-Activated Medulloblastoma
Authors: Cohen Kenneth J. , Munjapara Vasu , Aguilera Dolly , Castellino Robert C. , Stapleton Stacie L. , Landi Daniel , Ashley David M. , Rodriguez Fausto J. , Hawkins Cynthia , Yang Edward , London Wendy , Chi Susan , Bandopadhayay Pratiti
Published: December 2023

Representativeness Table
Supplementary Figures S1-S2 from A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Authors: Huffman Brandon M. , Feng Hanrong , Parmar Kalindi , Wang Junning , Kapner Kevin S. , Kochupurakkal Bose , Martignetti David B. , Sadatrezaei Golbahar , Abrams Thomas A. , Biller Leah H. , Giannakis Marios , Ng Kimmie , Patel Anuj K. , Perez Kimberly J. , Singh Harshabad , Rubinson Douglas A. , Schlechter Benjamin L. , Andrews Elizabeth , Hannigan Alison M. , Dunwell Stanley , Getchell Zoe , Raghavan Srivatsan , Wolpin Brian M. , Fortier Caroline , D'Andrea Alan D. , Aguirre Andrew J. , Shapiro Geoffrey I. , Cleary James M.
Published: December 2023

Figures S1-S2
Supplementary Fig. S3 from Safety and Efficacy of Tucatinib, Letrozole, and Palbociclib in Patients with Previously Treated HR+/HER2+ Breast Cancer
Authors: Shagisultanova Elena , Gradishar William , Brown-Glaberman Ursa , Chalasani Pavani , Brenner Andrew J. , Stopeck Alison , Parris Hannah , Gao Dexiang , McSpadden Tessa , Mayordomo Jose , Diamond Jennifer R. , Kabos Peter , Borges Virginia F.
Published: December 2023

PFS before and after palbociclib dose change
Supplementary Table S7 from A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response–Dependent Survival of Quiescent Cancer Cells
Authors: Calvo Veronica , Zheng Wei , Adam-Artigues Anna , Staschke Kirk A. , Huang Xin , Cheung Julie F. , Nobre Ana Rita , Fujisawa Sho , Liu David , Fumagalli Maria , Surguladze David , Stokes Michael E. , Nowacek Ari , Mulvihill Mark , Farias Eduardo F. , Aguirre-Ghiso Julio A.
Published: December 2023

Supplementary Table 7: KINOMEscan™ screening comparison of HC4, HC19, HC28 and GSK-157 at concentrations of 0.1, 1.0 and 10 mM versus RIPK1, AURKB, AXL, EPHB6, FLT3, KIT and KIT (V599D), kinases potently engaged by GSK157
Supplementary Table S5 from A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response–Dependent Survival of Quiescent Cancer Cells
Authors: Calvo Veronica , Zheng Wei , Adam-Artigues Anna , Staschke Kirk A. , Huang Xin , Cheung Julie F. , Nobre Ana Rita , Fujisawa Sho , Liu David , Fumagalli Maria , Surguladze David , Stokes Michael E. , Nowacek Ari , Mulvihill Mark , Farias Eduardo F. , Aguirre-Ghiso Julio A.
Published: December 2023

Supplementary Table 5: Aqueous kinetic solubility, Caco-2 permeability, plasma protein binding and hepatocyte stability of HC4, HC19, HC28 and GSK-157
Supplementary Table S3 from A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response–Dependent Survival of Quiescent Cancer Cells
Authors: Calvo Veronica , Zheng Wei , Adam-Artigues Anna , Staschke Kirk A. , Huang Xin , Cheung Julie F. , Nobre Ana Rita , Fujisawa Sho , Liu David , Fumagalli Maria , Surguladze David , Stokes Michael E. , Nowacek Ari , Mulvihill Mark , Farias Eduardo F. , Aguirre-Ghiso Julio A.
Published: December 2023

Supplementary Table 3: KINOMEscan™ screening comparison of HC4, HC19, HC28 and GSK-157 at concentrations of 0.1, 1.0 and 10 mM versus other eif2a kinases