bluuebunny/crossref_metadata_2025 huggingface dataset:
Serological Biomarkers of Extracellular Matrix Turnover and Neutrophil Activity Are Associated with Long-Term Use of Vedolizumab in Patients with Crohn’s Disease
Authors: Alexdottir Marta S. , Bourgonje Arno R. , Karsdal Morten A. , Pehrsson Martin , Loveikyte Roberta , van Dullemen Hendrik M. , Visschedijk Marijn C. , Festen Eleonora A. M. , Weersma Rinse K. , Faber Klaas Nico , Dijkstra Gerard , Mortensen Joachim H.
Published: July 2022

Crohn’s disease (CD) is a relapsing-remitting inflammatory disease of the gastrointestinal (GI) tract characterized by increased extracellular matrix (ECM) remodeling. The introduction of the α4β7-integrin inhibitor vedolizumab (VEDO) has improved disease management, although there is a high rate of primary non-response in patients with CD. We studied whether ECM biomarkers of neutrophil activity and mucosal damage could predict long-term response to VEDO in patients with CD. Serum levels of human neutrophil elastase (HNE)-derived fragments of calprotectin (CPa9-HNE), and matrix metalloproteinase (MMP)-derived fragments of type I (C1M), III (C3M), IV (C4M), and VI (C6Ma3) collagen, type III collagen formation (PRO-C3), basement membrane turnover (PRO-C4) and T-cell activity (C4G), were measured using protein fingerprint assays in patients with CD (n = 32) before VEDO therapy. Long-term response was defined as VEDO treatment of at least 12 months. CPa9-HNE was significantly increased at baseline in non-responders compared with responders (p < 0.05). C1M, C3M, C4M, C6Ma3, and PRO-C4 were also significantly increased at baseline in non-responders compared with responders (all p < 0.05). All biomarkers were associated with response to VEDO (all p < 0.05). To conclude, baseline levels of serum biomarkers for neutrophil activity and mucosal damage are linked to the pathology of CD, and are associated with long-term use of VEDO in patients with CD. Therefore, these biomarkers warrant further validation and could aid in therapeutic decision-making concerning vedolizumab therapy.
Anti-Fibrotic Effect of Synthetic Noncoding Decoy ODNs for TFEB in an Animal Model of Chronic Kidney Disease
Authors: Lee Sun-Jae , Kim Young-Ah , Park Kwan-Kyu
Published: July 2022

Despite emerging evidence suggesting that autophagy occurs during renal interstitial fibrosis, the role of autophagy activation in fibrosis and the mechanism by which autophagy influences fibrosis remain controversial. Transcription factor EB (TFEB) is a master regulator of autophagy-related gene transcription, lysosomal biogenesis, and autophagosome formation. In this study, we examined the preventive effects of TFEB suppression on renal fibrosis. We injected synthesized TFEB decoy oligonucleotides (ODNs) into the tail veins of unilateral ureteral obstruction (UUO) mice to explore the regulation of autophagy in UUO-induced renal fibrosis. The expression of interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and collagen was decreased by TFEB decoy ODN. Additionally, TEFB ODN administration inhibited the expression of microtubule-associated protein light chain 3 (LC3), Beclin1, and hypoxia-inducible factor-1α (HIF-1α). We confirmed that TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects. Collectively, these results suggest that TFEB may be involved in the regulation of autophagy and fibrosis and that regulating TFEB activity may be a promising therapeutic strategy against kidney diseases.
Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation
Authors: Arleevskaya Marina , Takha Elena , Petrov Sergey , Kazarian Gevorg , Renaudineau Yves , Brooks Wesley , Larionova Regina , Korovina Marina , Valeeva Anna , Shuralev Eduard , Mukminov Malik , Kravtsova Olga , Novikov Andrey
Published: July 2022

In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-genetic factors form tangles of interdependent relationships and, thereby, several interdependent external factors hit one vulnerable basic process at once, either provoking or reinforcing each other. Understanding the specific mechanisms by which environmental and individual factors impact an individual under RA risk in the preclinical stages can contribute to early disease diagnosis and, if the factor is modifiable, might be useful for the prevention or delay of its development.
Fluorescence Imaging Using Enzyme-Activatable Probes for Detecting Diabetic Kidney Disease and Glomerular Diseases
Authors: Yamada Kentaro , Takata Tomoaki , Iyama Takuji , Hamada Shintaro , Mae Yukari , Sugihara Takaaki , Isomoto Hajime
Published: July 2022

A clear identification of the etiology of glomerular disease is essential in patients with diabetes. Renal biopsy is the gold standard for assessing the underlying nephrotic pathology; however, it has the risk for potential complications. Here, we aimed to investigate the feasibility of urinary fluorescence imaging using an enzyme-activatable probe for differentiating diabetic kidney disease and the other glomerular diseases. Hydroxymethyl rhodamine green (HMRG)-based fluorescent probes targeting gamma-glutamyl transpeptidase (GGT) and dipeptidyl-peptidase (DPP) were used. Urinary fluorescence was compared between groups which were classified by their histopathological diagnoses (diabetic kidney disease, glomerulonephritis, and nephrosclerosis) as obtained by ultrasound-guided renal biopsy. Urinary fluorescence was significantly stronger in patients with diabetic kidney disease compared to those with glomerulonephritis/nephrosclerosis after DPP-HMRG, whereas it was stronger in patients with nephrosclerosis than in patients with glomerulonephritis after GGT-HMRG. Subgroup analyses of the fluorescence performed for patients with diabetes showed consistent results. Urinary fluorescence imaging using enzyme-activatable fluorescence probes thus represents a potential noninvasive assessment technique for kidney diseases in patients with diabetes.
Overexpressing PhytochromeInteractingFactor 8 of Myrothamnus flabellifolia Enhanced Drought and Salt Tolerance in Arabidopsis
Authors: Huang Zhuo , Tang Rong , Yi Xin , Xu Wenxin , Zhu Peilei , Jiang Cai-Zhong
Published: July 2022

Myrothamnus flabellifolia is the only woody resurrection plant found in the world and can survive from long-term desiccation. Therefore, M. flabellifolia could be considered as a valuable resource for study of plant adaptation to abiotic stress. However, few genes related to its drought tolerance have been functionally characterized and the molecular mechanisms underlying the stress tolerance of M. flabellifolia are largely unknown. The phytochrome interacting factor (PIF) family is a group of basic helix–loop–helix (bHLH) transcription factors and functions as the core regulator in plant growth and development. However, less is known of its participation in abiotic stress response. In this study, we isolated and characterized a dehydration-inducible PIF gene MfPIF8 from M. flabellifolia. Heterologous expression of MfPIF8 in Arabidopsis enhanced tolerance to drought and salinity stresses at seedling and adult stages. It significantly increased primary root length and stomatal aperture (ration of length/width) under stress treatments and decreased water loss rate. Compared with WT, the transgenic lines overexpressing MfPIF8 exhibited higher chlorophyll content and lower malondialdehyde accumulation. The abilities of osmotic adjustment and reactive oxygen species scavenging were also enhanced in MfPIF8 transgenic lines. These results suggest that MfPIF8 may participate in the positive regulation of abiotic stress responses. Additional investigation of its mechanism is needed in the future.
Taxonomy, Habitat Preference, and Niche Overlap of Two Arrow-Poison Flea Beetle Species of the Genus Polyclada in Sub-Saharan Africa (Coleoptera, Chrysomelidae)
Authors: Biondi Maurizio , D’Alessandro Paola , Cerasoli Francesco , De Simone Walter , Iannella Mattia
Published: July 2022

Coupling the geographic distribution and the ecological requirements of species often supports taxonomy and biogeography. In this contribution, we update the distribution of two flea beetle species of ethno-entomological interest, Polyclada bohemani and P. pectinicornis, by analyzing original data. In addition, we supply their main morphological diagnostic characters, describing their aedeagal and spermathecal shapes for the first time. We also assess their niche differences in terms of climatic and vegetation needs, by means of ecological niche modelling and remote sensing techniques. Several new localities were identified to improve knowledge of the geographical distribution of both species. Moreover, we located a wide climatic suitability overlap in East Africa for these two flea beetle species, while in other areas they show a clear separation. Our analysis also reports that P. bohemani is associated with areas of denser tree cover than P. pectinicornis. Finally, the lectotypes of Diamphidia bohemani Baly, 1861, Clytra pectinicornis Olivier, 1791, and Diamphidia compacta Fairmaire, 1887 are here designated and the new synonymy Clytra pectinicornis Olivier = Diamphidia compacta Fairmaire syn.nov. is proposed.
In Pursuit of Genetic Prognostic Factors and Treatment Approaches in Secondary Acute Myeloid Leukemia—A Narrative Review of Current Knowledge
Authors: Stefaniuk Paulina , Szymczyk Agnieszka , Podhorecka Monika
Published: July 2022

Secondary acute myeloid leukemia can be divided into two categories: AML evolving from the antecedent hematological condition (AHD-AML) and therapy related AML (t-AML). AHD-AML can evolve from hematological conditions such as myelodysplastic syndromes, myeloproliferative neoplasms, MDS/MPN overlap syndromes, Fanconi anemia, and aplastic anemia. Leukemic transformation occurs as a consequence of the clonal evolution—a process of the acquisition of mutations in clones, while previous mutations are also passed on, leading to somatic mutations accumulation. Compared de novo AML, secondary AML is generally associated with poorer response to chemotherapy and poorer prognosis. The therapeutic options for patients with s-AML have been confirmed to be limited, as s-AML has often been analyzed either both with de novo AML or completely excluded from clinical trials. The treatment of s-AML was not in any way different than de novo AML, until, that is, the introduction of CPX-351—liposomal daunorubicin and cytarabine. CPX-351 significantly improved the overall survival and progression free survival in elderly patients with s-AML. The only definitive treatment in s-AML at this time is allogeneic hematopoietic cell transplantation. A better understanding of the genetics and epigenetics of s-AML would allow us to determine precise biologic drivers leading to leukogenesis and thus help to apply a targeted treatment, improving prognosis.
Trends in Diagnosis and Surgical Treatment of Bone Metastases among Orthopedic Surgeons
Authors: Ciechanowicz Dawid , Kotrych Daniel , Dąbrowski Filip , Mazurek Tomasz
Published: July 2022

Background: The proper diagnosis and treatment of bone metastases are essential for patient survival. However, several strategies for the treatment are practiced. Therefore, the aim of the study was to analyze what factors influence the choice of a method of treatment. Methods: An online survey was conducted within the Polish Society of Orthopedics and Traumatology. It consisted of 45 questions and was divided into four main parts: Participant Characteristics, Diagnosis and Qualification, Treatment, and Clinical Cases. Results: A total number of 104 responses were collected. The most frequently chosen methods were: Intramedullary nail (IMN) + Resection + Polymethyl methacrylate (PMMA) (30.47%) and IMN without tumor resection (42.13%), and in third place, modular endoprosthesis (17.25%). The less experienced group of orthopedic surgeons more often (47.5% vs. 39.5%) decided to perform IMN without tumor resection than the more experienced group (p = 0.046). Surgeons from district hospitals less frequently (13.7% vs. 23.1%) would decide to use modular endoprosthesis than surgeons from university hospitals (p = 0.000076). Orthopedists who performed ≥ 11 bone metastases surgeries per year would more often use modular endoprosthesis (34.8% vs. 13.2%) than those who performed ≤ 10 operations per year (p = 0.000114). Conclusion: Experience, place of work, and the number of metastasis surgeries performed during a year may influence the choice of treatment method in patients with bone metastases.
Eating Habits, Risk of Breast Cancer, and Diet-Dependent Quality of Life in Postmenopausal Women after Mastectomy
Authors: Socha Małgorzata , Sobiech Krzysztof A.
Published: July 2022

The present study examined dietary risk factors for breast cancer, their association with quality of life, and changes in eating habits in postmenopausal women after mastectomy. The study included 210 women with histologically confirmed invasive breast cancer and 225 women without a cancer diagnosis. Questionnaire data on frequency of intake of 40 different foods, the Block Food Frequency Questionnaire, and SF-36 for evaluation of quality of life were used. All questionnaire data in the patient group were collected after diagnosis. Questions about eating habits covered two time points—before breast cancer diagnosis and after completion of treatment. Logistic regression was applied to calculate the odds ratios of breast cancer risk and 95% confidence intervals. A significant positive association was found between the risk of breast cancer and more frequent intake of red meat, smoked products, offal, animal fat, white bread, potatoes, and sweets, high intake of total fat, and low consumption of dietary fibre. Foods that were inversely associated with the risk of breast cancer included fish, vegetables, fruit, wholemeal bread, and groats. The relationship between quality of life and dietary habits according to the Block Eating Frequency Questionnaire was analysed using multiple regression. It was shown that high intake of total fat reduces the quality of life in its mental components. We observed a positive change in eating habits after cancer diagnosis, albeit not always to the level in the control group. As an important lifestyle component, the diet is of great significance for primary prevention of breast cancer as well as for improving the quality of life of breast cancer patients.
Metformin Improves the Hepatic Steatosis Index in Non-Obese Patients with Polycystic Ovary Syndrome
Authors: Riemann Annika , Blaschke Martina , Jauho-Ghadimi Annukka , Siggelkow Heide , Gollisch Katja Susanne Claudia
Published: July 2022

Non-alcoholic fatty liver disease (NAFLD) is a common yet little recognized health problem in women with polycystic ovary syndrome (PCOS). In a retrospective setting, we investigated the effects of metformin treatment on the hepatic steatosis index (HSI) as a readily available biomarker panel for NAFLD. HSI values of >36 are considered to be highly suggestive for NAFLD. In our cohort, HSI values indicating NAFLD were found in 60/81 (74.1%) women at baseline. The mean HSI improved significantly after the metformin treatment from 43.2 ± 1.0 to 41.0 ± 1.1. Subgroup analyses of non-obese (body mass index (BMI) < 30 kg/m2), obese (BMI 30–35 kg/m2) and very obese (BMI > 35 kg/m2) women yielded mean baseline HSI values of 35.5 ± 4.5, 41.2 ± 2.7 and 51.2 ± 4.7, respectively. A significant improvement in the HSI of 1.5 ± 2.1 was observed after metformin treatment in non-obese women but not in the obese subgroups. The data suggest a new aspect of metformin treatment in non-obese PCOS patients, namely, a possible improvement in NAFLD. This study highlighted hepatic steatosis as a common comorbidity in PCOS patients that can severely affect their long-term health, and therefore, deserves more attention in the management of PCOS patients.
Long-Term Adherence to Levothyroxine Replacement Therapy in Thyroidectomized Patients
Authors: Bocale Raffaella , Desideri Giovambattista , Barini Angelina , D’Amore Annamaria , Boscherini Mauro , Necozione Stefano , Lombardi Celestino Pio
Published: July 2022

(1) Background: We evaluated the long term adherence to two distinct formulations of levothyroxine (L-T4), liquid or solid, which are differently influenced by concomitant food ingestion. (2) Methods: A total of 106 thyroidectomized patients (82 female, mean age 58.2 ± 13.3 years) on L-T4 replacement therapy in either liquid (n = 52) or solid formulation (n = 54) were administered the four-item Medication Adherence Questionnaire (MAQ). (3) Results: The study population had 59.4% adherers and 40.6% non-adherers. The global MAQ score was significantly better in patients under liquid L-T4 in comparison to those under solid L-T4 (0.42 ± 0.82 vs. 0.83 ± 0.95, respectively, p = 0.0085). The patients on tablet L-T4 forgot to take their medication more frequently than those on liquid LT4 treatment (p = 0.0159) and were more often careless at times about taking their medication (p = 0.007), whilst about one in two thyroidectomized patients preferred tablets for lifetime medication therapy. The global MAQ score was directly correlated with the circulating TSH levels in the whole study population (0.700, p < 0.0001) and inversely correlated with both the FT3 (−0.220, p = 0.0232) and FT4 (−0.327, p = 0.0006) serum concentrations. (4) Conclusions: Long-term adherence to L-T4 treatment was globally satisfactory although it was better for the liquid formulation, which appears to represent an easier-to-manage L-T4 replacement therapy for most thyroidectomized patients, particularly for those with difficulties in taking L-T4 while fasting.
Typical and Atypical Symptoms of Petrous Apex Cholesterol Granuloma: Association with Radiological Findings
Authors: Vinciguerra Alessandro , Turri-Zanoni Mario , Verillaud Benjamin , Guichard Jean-Pierre , Spirito Luca , Karligkiotis Apostolos , Castelnuovo Paolo , Herman Philippe
Published: July 2022

Objective: Petrous apex cholesterol granuloma (PACG) is a lesion that can give rise to different symptoms, and correlations with etiopathology are ambiguous. The aim of this study is to analyze the association between PACG symptoms and radiological findings at presentation, in order to establish a reproduceable pre-operative radiological evaluation and guide the surgical indication. Methods: PACG patients were collected in two tertiary care hospitals. All cases underwent CT/MRI to evaluate the cyst localization and erosion of surrounding structures. Typical and atypical symptoms were then analyzed and compared to radiologic findings established in accordance with the literature. Results: Twenty-nine patients were recruited; the most common symptoms were headache (69%), diplopia (20.7%) and fainting (24.1%), an atypical clinical manifestation related to jugular tubercle involvement. Significant associations between symptoms and radiologic findings were noted in terms of headache and temporal lobe compression (p = 0.04), fainting and jugular tubercle erosion (p < 0.001), vestibular symptoms and internal auditory canal erosion (p = 0.02), facial paresthesia and Meckel’s cave compression (p = 0.03), diplopia and Dorello canal involvement (p = 0.001), and tinnitus and cochlear basal turn erosion (p < 0.001). All patients were treated via an endoscopic–endonasal approach, in which extension was tailored to each case. At a median follow-up of 46 months, 93.1% of patients experienced resolution of symptoms. Conclusions: This clinico-radiological series demonstrates associations between symptoms and anatomical subsites involved with PACG. Hence, it may guide the surgeon at the time of surgical decision, since it asserts that typical and atypical symptoms are actually related to PACG.
On the Fate of Floating Marine Debris Carried to the Sea through the Main Rivers of Indonesia
Authors: Dobler Delphine , Maes Christophe , Martinez Elodie , Rahmania Rinny , Gautama Budhi Gunadharma , Farhan Aulia Riza , Dounias Edmond
Published: July 2022

Plastic debris has become an acute marine pollution concern worldwide in modern times. Indonesia is particularly impacted because of its high population density, heavy rainfall rate and numerous coastlines. A Lagrangian analysis was performed to simulate the fate of fictive marine debris drifting along surface currents, including tides and Stokes drift. The fictive particles were released according to the discharge rate of 21 Indonesian rivers and advected over 4 years. Most of the particles were stranded along Indonesian coasts (60%), before 6 months had elapsed (84%) and within a range of 1000 km (76%). The time variability exhibited two seasonal peaks, one centered on January-February and one on June-July, consistent with in situ observations. However, the results underline the complexity of performing direct comparisons between in situ observations and numerical simulations for stranded waste due to limited measurements and the heterogeneity of field methods and protocols.
Species Diversity, Distribution, and Phylogeny of Exophiala with the Addition of Four New Species from Thailand
Authors: Thitla Tanapol , Kumla Jaturong , Khuna Surapong , Lumyong Saisamorn , Suwannarach Nakarin
Published: July 2022

The genus Exophiala is an anamorphic ascomycete fungus in the family Herpotrichiellaceae of the order Chaetothyriales. Exophiala species have been classified as polymorphic black yeast-like fungi. Prior to this study, 63 species had been validated, published, and accepted into this genus. Exophiala species are known to be distributed worldwide and have been isolated in various habitats around the world. Several Exophiala species have been identified as potential agents of human and animal mycoses. However, in some studies, Exophiala species have been used in agriculture and biotechnological applications. Here, we provide a brief review of the diversity, distribution, and taxonomy of Exophiala through an overview of the recently published literature. Moreover, four new Exophiala species were isolated from rocks that were collected from natural forests located in northern Thailand. Herein, we introduce these species as E. lamphunensis, E. lapidea, E. saxicola, and E. siamensis. The identification of these species was based on a combination of morphological characteristics and molecular analyses. Multi-gene phylogenetic analyses of a combination of the internal transcribed spacer (ITS) and small subunit (nrSSU) of ribosomal DNA, along with the translation elongation factor (tef), partial β-tubulin (tub), and actin (act) genes support that these four new species are distinct from previously known species of Exophiala. A full description, illustrations, and a phylogenetic tree showing the position of four new species are provided.
Engineered Production of Isobutanol from Sugarcane Trash Hydrolysates in Pichia pastoris
Authors: Bumrungtham Pornsiri , Promdonkoy Peerada , Prabmark Kanoknart , Bunterngsook Benjarat , Boonyapakron Katewadee , Tanapongpipat Sutipa , Champreda Verawat , Runguphan Weerawat
Published: July 2022

Concerns over climate change have led to increased interest in renewable fuels in recent years. Microbial production of advanced fuels from renewable and readily available carbon sources has emerged as an attractive alternative to the traditional production of transportation fuels. Here, we engineered the yeast Pichia pastoris, an industrial powerhouse in heterologous enzyme production, to produce the advanced biofuel isobutanol from sugarcane trash hydrolysates. Our strategy involved overexpressing a heterologous xylose isomerase and the endogenous xylulokinase to enable the yeast to consume both C5 and C6 sugars in biomass. To enable the yeast to produce isobutanol, we then overexpressed the endogenous amino acid biosynthetic pathway and the 2-keto acid degradation pathway. The engineered strains produced isobutanol at a titer of up to 48.2 ± 1.7 mg/L directly from a minimal medium containing sugarcane trash hydrolysates as the sole carbon source. To our knowledge, this is the first demonstration of advanced biofuel production using agricultural waste-derived hydrolysates in the yeast P. pastoris. We envision that our work will pave the way for a scalable route to this advanced biofuel and further establish P. pastoris as a versatile production platform for fuels and high-value chemicals.
The Logic of Urban Land System Reform in China—A Policy Analysis Framework Based on Punctuated-Equilibrium Theory
Authors: Xiong Shangxun , Wang Hui
Published: July 2022

Land system reform is inseparable from land policy evolution in the reform process. Understanding land system reform from the perspective of policy evolution is crucial for the further deepening of the reform. Based on a review of policy documents on urban land system reform over the past 70 years (1949–2021), this paper applies a policy analysis framework based on punctuated-equilibrium theory to analyze the process of China’s urban land system reform and its inner mechanism. We conclude that under the framework of punctuated-equilibrium theory, the reform process of the urban land system can be divided into three equilibrium periods and two punctuated periods: Equilibrium Period I (1949–1978), Punctuated Period I (1979–1990), Equilibrium Period II (1991–2000), Punctuated Period II (2001–2007), and Equilibrium Period III (2008–2021). The reform of China’s urban land system shows a non-linear change that alternates between gradual change and punctuated evolution. Further analysis demonstrates that the change of the policy image, the transfer of the policy venue and the shock of focus events are the vital driving factors resulting in the alternation between equilibrium and punctuation.
Land Use Affects Soil Water Balance and Soil Desiccation within the Soil Profile: Evidence from the Western Loess Plateau Case
Authors: Wang Linlin , Luo Zhuzhu , Li Lingling , Xie Junhong , Fudjoe Setor Kwami , Zechariah Effah
Published: July 2022

This study evaluated the properties of soil water dynamics and desiccation to a depth of 500 cm and tested the idea that land use affects soil drying in deep profiles. Four land use types were chosen: farmland, artificial forest and grassland, and abandoned land. Soil water content was most outstanding under long-term wheat fields, but average soil water content under artificial vegetation of Caragana korshinskii Kom. and alfalfa dropped to 6–8% within the 160–500 cm soil profile, very near to the 7.0% wilting point. Long-term continuous maize cultivation in a fully mulched ridge–furrow system significantly depleted soil water and resulted in a dried soil layer with a thickness of 240 cm. Short-term or long-term land abandonment enhanced soil reservoir and reduced soil water storage deficit degree compared to long-term maize and artificial vegetation. Soil water storage in the 160–500 cm soil profile was depleted by 240 and 464 mm under long-term maize and Caragana korshinskii Kom., respectively, by 267, 319, 381, and 463 mm under 5-, 10-, 20-, and 30-year alfalfa, and by −58, 278, 234, and 93 mm under 5-, 10-, 20-, and 30-year abandonment land, respectively, compared to long-term wheat. Based on the analysis of long-term experimental results, this study shows that the phenomenon of soil drying caused by long-term intensive maize production cannot be ignored in semi-arid areas and that natural re-vegetation under long-term abandonment, rather than artificial vegetation, may be the best type of vegetation reconstruction for this region based on soil water balances.
An Intelligent Homogeneous Model Based on an Enhanced Weighted Kernel Self-Organizing Map for Forecasting House Prices
Authors: Cheng Ching-Hsue , Tsai Ming-Chi
Published: July 2022

Accurately forecasting housing prices will enable investors to attain profits, and it can provide information to stakeholders that housing prices in the community are falling, stabilizing, or rising. Previous studies on housing price forecasting mostly used hedonic pricing and weighted regression methods, which led to the lack of consideration of the nonlinear relationship model and its explanatory power. Furthermore, the attribute data of housing price forecasts are a heterogeneous study, and they are difficult to forecast accurately. Therefore, this study proposes an intelligent homogeneous model based on an enhanced weighted kernel self-organizing map (EW-KSOM) for forecasting house prices; that is, this study proposes an EW-KSOM algorithm to cluster the collected data and then applies random forest, extra tree, multilayer perception, and support vector regression to forecast the house prices of full, district, and apartment complex data. In the experimental comparison, we compare the performance of the proposed enhanced weighted kernel self-organizing map with the listing clustering methods. The results show that the best forecast algorithm is the combined EW-KSOM and random forest under the root mean square error and root-relative square error, and the proposed method can effectively improve the forecast capability of housing prices and understand the influencing factors of housing prices in full and important districts. Furthermore, we obtain that the top five key factors influencing house prices are transferred land area, house age, building transfer total area, population percentage, and the total number of floors. Lastly, the research results can provide references for investors and related organizations.
Solute-Induced Perturbation of the Solvent Microstructure in Aqueous Electrolyte Solutions: Some Uses and Misuses of Structure Making/Breaking Criteria
Authors: Chialvo Ariel A. , Crisalle Oscar D.
Published: July 2022

In this article, we raise awareness about the misuses of frequently invoked criteria for structure making/breaking phenomena, resulting from the absence of any explicit cause–effect relationship between the proposed markers and the microstructural perturbation of the solvent induced by the solute. First, we support our assessment with rigorous molecular-based foundations to determine, directly and quantitatively, the solute-induced perturbation of the solvent structure leading to an unambiguous definition of a structure making/breaking event. Then, we highlight and discuss the sources of concealed ambiguities in two of the most frequently invoked structure making/breaking criteria, i.e., Hepler’s thermal expansivity-based and Jones–Dole’s B coefficient-based markers. Finally, we illustrate how the implementation of rigorous molecular-based arguments, in conjunction with the available experimental evidence on a variety of aqueous species at infinite dilution, rule out the validity of these two criteria as structure making/breaking markers and suggest their discontinuation to avoid the perpetuation of myths.
Fatigue Damage Behaviors of TRC-Strengthened RC Beams
Authors: Sheng Jie , Yu Zongjian , Dou Guotao , Liu Hao
Published: July 2022

For the investigation of fatigue damage behavior of textile reinforced concrete (TRC)-strengthened RC beams, in this study, eight RC beams were fabricated, and five of them were strengthened with TRC and tested under fatigue loading until failure, using a four-point bending setup. Research parameters included reinforcement ratio, textile ratio, and strengthening methods (single-side and U-wrapped). The failure mode, fatigue life, fatigue deformation, and other properties of TRC-strengthened beams were analyzed. Experimental results revealed that there were two fatigue failure modes for TRC-strengthened RC beams. In the first mode, the textile was snapped, but the steel bars did not rupture. In the second mode, both the textile and steel bars broke. Fatigue failure modes depended on the textile ratio. The TRC-strengthened beam’s fatigue life was significantly higher than the non-strengthened RC beam. At the same textile ratio, the TRC-strengthened beam’s fatigue life using the single-side method was longer than that using the U-wrapped method. With the increase in fatigue loading time, the midspan deflection of the TRC-strengthened beam was developed in three stages, namely rapid development stage, stable development stage, and destabilized development stage. The residual deflection and strain damage accumulation of tensile steel bars of TRC-strengthened beams were significantly reduced with the increase in textile or reinforcement ratios; thus, the beam’s fatigue life was prolonged.
The Effect of Different Nanomaterials Additions in Clay-Based Composites on Electromagnetic Transmission
Authors: Vrdoljak Ivan , Brdarić Jelena , Rupčić Slavko , Marković Berislav , Miličević Ivana , Mandrić Vanja , Varevac Damir , Tatar Dalibor , Filipović Nikolina , Szenti Imre , Kukovecz Ákos
Published: July 2022

In this study, clay composites were subjected to electromagnetic transmission testing at frequencies in the region of non-ionizing radiation. Specimens were made with partial substitution of clay with different admixtures by mass. Admixtures used were Fly Ash, four different particle sizes and phases of Titanium Dioxide (TiO2), Zinc Ferrite (ZnFe2O4), Maghemite (γ-Fe2O3) and Antimony Tin Oxide (ATO). The additives were thoroughly (chemically, structurally, morphologically) characterized. The replacement percentage was 5 wt.%. Electromagnetic transmission assessment included S21 transmission coefficient measurements for samples with different additives. The lowest transmission was reported for the clay specimens with ATO and Titanium Dioxide, especially at higher frequencies. A decrease in the transmission parameter with increasing specimen thickness was also confirmed.
Characterization and Ofloxacin Adsorption Studies of Chemically Modified Activated Carbon from Cassava Stem
Authors: Sulaiman Nurul Syuhada , Mohamad Amini Mohd Hazim , Danish Mohammed , Sulaiman Othman , Hashim Rokiah , Demirel Samet , Demirel Gaye Kose
Published: July 2022

Cassava is a type of crop popular in Asian countries. It can be easily cultivated and grows to a mature plant in 9 months. Considering its availability, this work studied activated carbon based on cassava stem. Ofloxacin was chosen as the adsorbate, simulating the wastewater from the pharmaceutical industry. Cassava stem was ground into particles and heated to the activated state, 787 °C. The cassava-stem-activated carbon was further treated with the surface modifier, namely sodium hydroxide and zinc chloride, to study the improvement in ofloxacin adsorption. Prepared adsorbents were characterised using the SEM, FT-IR, XRD, DSC and TGA methods before being evaluated through batch adsorption, thermodynamic, and kinetic studies. The surface area analysis indicates that treatment of the activated carbon with NaOH and ZnCl2 increases the surface area due to the removal of organic content by the chemicals. Better ofloxacin adsorption of all activated carbon samples can be obtained with solutions at pH 8. An endothermic reaction was predicted, shown by higher ofloxacin adsorption at a higher temperature, supported by a positive value of ΔH° in the thermodynamic studies. The negative values of ΔG° revealed that adsorptions were spontaneous. The higher R2 values indicate that the adsorption process follows the pseudo-second-order equation of kinetic study. The maximum adsorption capacities are 42.37, 62.11, 62.89 and 58.82 mg/g for raw cassava stem (RC), cassava-stem-activated carbon (AC), NaOH-modified cassava-stem-activated carbon (NAC), and ZnCl2 modified cassava-stem-activated carbon (ZAC). The adsorption capacity is good compared to previous works by other researchers, making it a possible alternative material for the pharmaceutical industry’s wastewater treatment.
Adsorption of Naphthalene on Clay Minerals: A Molecular Dynamics Simulation Study
Authors: Chen Zhixin , Hu Liming
Published: July 2022

Naphthalene, as one of the representative polycyclic aromatic hydrocarbons, widely exists in contaminated sites and is a potential threat to human health due to its high mobility in soil. The interaction between naphthalene and clay minerals is of great significance to the environmental behavior of naphthalene and the design of remediation technology. In this study, montmorillonite and kaolinite were selected as representative clay minerals. Naphthalene adsorption behavior on mineral surfaces and water-wet kaolinite surfaces was investigated using molecular dynamics (MD) simulation. The interaction energy was calculated to represent the interaction between naphthalene and soil fractions, and the relative concentration and density distribution of naphthalene was analyzed to describe the distribution of naphthalene on the clay surfaces. The self-diffusion coefficient of naphthalene was obtained to represent its mobility under different water content. The electron density calculation was performed to reveal the different adsorption behavior of naphthalene on different surfaces of kaolinite. The simulation results show that montmorillonite had a stronger interaction with naphthalene due to larger electrostatic interaction energy compared to kaolinite, and naphthalene distributed more intensively on the montmorillonite surface. With regards to kaolinite, naphthalene tended to be absorbed on the alumina octahedral surface rather than the silicon tetrahedral surface due to the weak hydron bond interaction. The results indicate that water impeded the adsorption of naphthalene, and the optimal initial thickness of water film, which was 10 Å, was put forward for the application of thermal remediation technology. Furthermore, the average interaction energies between water and mineral surfaces largely depended on the water content, and the competitive adsorption between water and naphthalene only occurred under absorbed and bound water conditions. Overall, the knowledge of naphthalene–soil fractions interaction gained in this study is critical to the understanding of the environmental behavior of naphthalene and the reference for remediation technology.
Novel Electromagnetic Characterization Methods for New Materials and Structures in Aerospace Platforms
Authors: Ramos David , Cidrás José , Plaza Borja , Moravec Carolina , de la Torre Antonia , Frövel Malte Richard Karl , Poyatos David
Published: July 2022

The tendency over the last decades in the aerospace industry is to substitute classic metallic materials with new composite materials such as carbon fiber composites (CFC), fiber glass, etc., as well as adding electronic devices to ensure the safety and proper platform operation. Due to this, to protect the aircraft against the Electromagnetic Environmental Effects (E3), it is mandatory to develop accurate electromagnetic (EM) characterization measurement systems to analyze the behavior of new materials and electronic components. In this article, several measurement methods are described to assess the EM behavior of the samples under test: microstrip transmission line for a surface current analysis, free space to obtain intrinsic features of the materials and shielding effectiveness (SE) approaches to figure out how well they isolate from EM fields. The results presented in this work show how the different facilities from the National Institute of Aerospace Technology (INTA) are suitable for such purposes, being capable of measuring a wide variety of materials, depending on the type of test to be carried out.
Determination of 238U and 40K Radionuclide Concentrations in Some Granite Rocks by Gamma Spectroscopy and Energy Dispersive X-ray Analysis
Authors: Al-Ghamdi Hanan , El-Nahal M. A. , Saleh I. H. , Elsafi Mohamed , Sayyed M. I. , Almuqrin Aljawhara H.
Published: July 2022

Uranium-238 (238U) and potassium-40 (40K) are important naturally occurring radionuclides. Gamma spectroscopy is a direct, non-destructive method used to determine radionuclide concentrations, but it suffers from the interference of gamma lines. 40K gamma spectroscopy is affected by background interference, which leads to a reduction in the minimum detectable activity. The energy dispersive X-ray analytical technique is quick, with fewer interference problems or background effects. However, it is an indirect method for calculating and deducing the concentrations of isotopes. The aim of the present study was to compare and evaluate both techniques so that they can be utilized efficiently. The results of 238U and 40K were measured by well-calibrated gamma spectroscopy and energy dispersive X-ray techniques. the results indicated that Halayeb White granite is the most environmentally safe compared to the other two types because it contains a very low concentration of uranium 238 and potassium 40.
Estimation of Drag Finishing Abrasive Effect for Cutting Edge Preparation in Broaching Tool
Authors: Pérez-Salinas Cristian F. , del Olmo Ander , López de Lacalle L. Norberto
Published: July 2022

In recent years, cutting edge preparation became a topic of high interest in the manufacturing industry because of the important role it plays in the performance of the cutting tool. This paper describes the use of the drag finishing DF cutting edge preparation process on the cutting tool for the broaching process. The main process parameters were manipulated and analyzed, as well as their influence on the cutting edge rounding, material remove rate MRR, and surface quality/roughness (Ra, Rz). In parallel, a repeatability and reproducibility R&R analysis and cutting edge radius re prediction were performed using machine learning by an artificial neural network ANN. The results achieved indicate that the influencing factors on re, MRR, and roughness, in order of importance, are drag depth, drag time, mixing percentage, and grain size, respectively. The reproducibility accuracy of re is reliable compared to traditional processes, such as brushing and blasting. The prediction accuracy of the re of preparation with ANN is observed in the low training and prediction errors 1.22% and 0.77%, respectively, evidencing the effectiveness of the algorithm. Finally, it is demonstrated that the DF has reliable feasibility in the application of edge preparation on broaching tools under controlled conditions.
Measurement of Water Absorption of Recycled Aggregate
Authors: Duan Zhenhua , Zhao Wenjing , Ye Taohua , Zhang Yunhui , Zhang Chuanchuan
Published: July 2022

Owing to the high absorption capacity of recycled aggregate (RA), it is crucial to accurately measure its saturated-surface-dried water absorption (WSSD), which largely affects an effective water-to-binder ratio of recycled aggregate concrete. In this study, existing measurement methods for the WSSD of RA are extensively reviewed, including Wiping, Slumping, Centrifugation, Infrared, Evaporation, Airflow drying, Conductivity, Pycnometer, Hydrostatic balance, and Extrapolation. In particular, the physical principles and operability of these methods are emphasized. It was determined that the accuracy of all test results was not satisfactory. For example, the water in pores with an open-ended direction that was opposite to the centrifugal force could largely be retained. In Airflow drying, the temperature change was significantly delayed. In addition, in Hydrostatic balance, RA would pre-absorb water before determining the initial reading. Therefore, several suggestions for optimizing these methods are presented, such as the combination of Evaporation and Airflow drying, the liquid selection in Hydrostatic balance, and the addition of a tiny mixer in each centrifuge tube. In summary, this review facilitates the development of an accurate and convenient method for measuring the WSSD of RA.
Pilot Evaluation of Sealer-Based Root Canal Obturation Using Epoxy-Resin-Based and Calcium-Silicate-Based Sealers: A Randomized Clinical Trial
Authors: Song Minju , Park Min-Gyu , Kwak Sang-Won , Kim Ruben H. , Ha Jung-Hong , Kim Hyeon-Cheol
Published: July 2022

The purpose of this randomized controlled clinical trial was to assess the short-term clinical effectiveness of sealer-based root canal obturation using calcium-silicate-based sealer (CSBS) and epoxy-resin-based sealer (ERBS). A total of eighty patients (eighty teeth) were enrolled and seventy-two patients (seventy-two teeth) were randomly assigned into four different sealer groups: AH Plus (AH, Dentsply Sirona), ADseal (AD, Meta Biomed), CeraSeal (CS, Meta Biomed), or EndoSeal TCS (ES, Maruchi). At the first visit, root canal treatment was performed using ProTaper. Next, the NiTi file system and passive ultrasonic irritation was applied with 2.5% NaOCl. At the second visit, the teeth were obturated with a sealer-based obturation technique using the assigned sealer. The quality of filling obturation was evaluated with postoperative radiographs in terms of the presence of voids and sealer extrusion. The patients were recalled at 1-week, 1-month, and 3-month intervals, and pain levels were measured using visual analog scales (VAS), and clinical examination performed with percussion and palpation. Radiographs were also taken. The results were statistically compared by using the χ2 test or Fisher exact test. Among the 80 teeth included, 72 teeth received allocated intervention and 71 teeth were included in the analysis (98.6% recall). There was no significant difference among the sealers in void and sealer extrusion (p > 0.05). Postoperative pain was not indicated prominently regardless of the type of sealer. For a 3-month follow-up period, all cases were maintained successfully except for one case from AD. According to the findings, there was no significant difference between CSBS and ERBS in terms of postoperative pain or the healing process, and the variation in filling quality appears to be linked to the properties of each product.
Application of the Gray Wolf Optimization Algorithm in Active Disturbance Rejection Control Parameter Tuning of an Electro-Hydraulic Servo Unit
Authors: Gao Bingwei , Guan Hao , Shen Wei , Ye Yongtai
Published: July 2022

A valve-controlled hydraulic cylinder system has the characteristics of uncertainty and time-variance, and the electro-hydraulic servo unit encounters shock, vibration, and other external interference when working, which seriously affect the stability of the valve-controlled hydraulic cylinder system. Therefore, it is necessary to introduce an active disturbance rejection controller (ADRC) into the electro-hydraulic servo control. However, there are many ADRC parameters, and it is difficult to set these only with expert experience. Therefore, we propose applying the gray wolf optimization algorithm (GWO) to the ADRC, to auto-tune the parameters and find the optimal solution. In addition, the advantages of the GWO in ADRC parameter tuning are proven and analyzed. The simulation and experimental results showed that the GWO algorithm had a faster mean time for parameter tuning and the smallest fitness value (integrated time and absolute error), compared to the particle swarm optimization algorithm and genetic algorithm. Moreover, a valve-controlled cylinder system, after parameter tuning by the gray wolf optimization algorithm, could accurately adjust the parameters of the auto-disturbance rejection controller, with a faster response speed, smaller overshoot, and better anti-disturbance ability.