bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning Algorithms to Detect Subclinical Keratoconus: Systematic Review
Authors: Maile Howard , Li Ji-Peng Olivia , Gore Daniel , Leucci Marcello , Mulholland Padraig , Hau Scott , Szabo Anita , Moghul Ismail , Balaskas Konstantinos , Fujinami Kaoru , Hysi Pirro , Davidson Alice , Liskova Petra , Hardcastle Alison , Tuft Stephen , Pontikos Nikolas
Published: October 2021

Background

Keratoconus is a disorder characterized by progressive thinning and distortion of the cornea. If detected at an early stage, corneal collagen cross-linking can prevent disease progression and further visual loss. Although advanced forms are easily detected, reliable identification of subclinical disease can be problematic. Several different machine learning algorithms have been used to improve the detection of subclinical keratoconus based on the analysis of multiple types of clinical measures, such as corneal imaging, aberrometry, or biomechanical measurements.

Objective

The aim of this study is to survey and critically evaluate the literature on the algorithmic detection of subclinical keratoconus and equivalent definitions.

Methods

For this systematic review, we performed a structured search of the following databases: MEDLINE, Embase, and Web of Science and Cochrane Library from January 1, 2010, to October 31, 2020. We included all full-text studies that have used algorithms for the detection of subclinical keratoconus and excluded studies that did not perform validation. This systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations.

Results

We compared the measured parameters and the design of the machine learning algorithms reported in 26 papers that met the inclusion criteria. All salient information required for detailed comparison, including diagnostic criteria, demographic data, sample size, acquisition system, validation details, parameter inputs, machine learning algorithm, and key results are reported in this study.

Conclusions

Machine learning has the potential to improve the detection of subclinical keratoconus or early keratoconus in routine ophthalmic practice. Currently, there is no consensus regarding the corneal parameters that should be included for assessment and the optimal design for the machine learning algorithm. We have identified avenues for further research to improve early detection and stratification of patients for early treatment to prevent disease progression.
Assessing Values and Preferences Toward SARS-CoV-2 Self-testing Among the General Population and Their Representatives, Health Care Personnel, and Decision-Makers: Protocol for a Multicountry Mixed Methods Study
Authors: Shilton Sonjelle , Ivanova Reipold Elena , Roca Álvarez Albert , Martínez-Pérez Guillermo Z
Published: October 2021

Background

Accessible, safe, and client-centered SARS-CoV-2 testing services are an effective way to halt its transmission. Testing enables infected individuals to isolate or quarantine to prevent further transmission. In countries with limited health systems and laboratory capacity, it can be challenging to provide accessible and safe screening for COVID-19. Self-testing provides a convenient, private, and safe testing option; however, it also raises important concerns about lack of counseling and ensuring timely reporting of self-test results to national surveillance systems. Investigating community members’ views and perceptions regarding SARS-CoV-2 self-testing is crucial to inform the most effective and safe strategies for implementing said testing.

Objective

We aimed to determine whether SARS-CoV-2 self-testing was useful to diagnose and prevent the spread of SARS-CoV-2 for populations in low-resource settings and under which circumstances it would be acceptable.

Methods

This multisite, mixed methods, observational study will be conducted in 9 countries—Brazil, India, Indonesia, Kenya, Malawi, Nigeria, Peru, the Philippines, and South Africa—and will consists of 2 components: cross-sectional surveys and interviews (semistructured and group) among 4 respondent groupings: the general population, general population representatives, health care workers, and decision-makers. General population and health care worker survey responses will be analyzed separately from each other, using bivariate and multivariate inferential analysis and descriptive statistics. Semistructured interviews and group interviews will be audiorecorded, transcribed, and coded for thematic comparative analysis.

Results

As of November 19, 2021, participant enrollment is ongoing; 4364 participants have been enrolled in the general population survey, and 2233 participants have been enrolled in the health care workers survey. In the qualitative inquiry, 298 participants have been enrolled. We plan to complete data collection by December 31, 2021 and publish results in 2022 via publications, presentations at conferences, and dissemination events specifically targeted at local decision-makers, civil society, and patient groups.

Conclusions

The views and perceptions of local populations are crucial in the discussion of the safest strategies for implementing SARS-CoV-2 self-testing. We intend to identify sociocultural specificities that may hinder or accelerate the widespread utilization of SARS-CoV-2 self-testing.

International Registered Report Identifier (IRRID)

DERR1-10.2196/33088
Leveraging Large-Scale Electronic Health Records and Interpretable Machine Learning for Clinical Decision Making at the Emergency Department: Protocol for System Development and Validation (Preprint)
Authors: Liu Nan , Xie Feng , Siddiqui Fahad Javaid , Ho Andrew Fu Wah , Chakraborty Bibhas , Nadarajan Gayathri Devi , Tan Kenneth Boon Kiat , Ong Marcus Eng Hock
Published: October 2021

BACKGROUND

There is a growing demand globally for emergency department (ED) services. An increase in ED visits has resulted in overcrowding and longer waiting times. The triage process plays a crucial role in assessing and stratifying patients’ risks and ensuring that the critically ill promptly receive appropriate priority and emergency treatment. A substantial amount of research has been conducted on the use of machine learning tools to construct triage and risk prediction models; however, the black box nature of these models has limited their clinical application and interpretation.

OBJECTIVE

In this study, we plan to develop an innovative, dynamic, and interpretable System for Emergency Risk Triage (SERT) for risk stratification in the ED by leveraging large-scale electronic health records (EHRs) and machine learning.

METHODS

To achieve this objective, we will conduct a retrospective, single-center study based on a large, longitudinal data set obtained from the EHRs of the largest tertiary hospital in Singapore. Study outcomes include adverse events experienced by patients, such as the need for an intensive care unit and inpatient death. With preidentified candidate variables drawn from expert opinions and relevant literature, we will apply an interpretable machine learning–based AutoScore to develop 3 SERT scores. These 3 scores can be used at different times in the ED, that is, on arrival, during ED stay, and at admission. Furthermore, we will compare our novel SERT scores with established clinical scores and previously described black box machine learning models as baselines. Receiver operating characteristic analysis will be conducted on the testing cohorts for performance evaluation.

RESULTS

The study is currently being conducted. The extracted data indicate approximately 1.8 million ED visits by over 810,000 unique patients. Modelling results are expected to be published in 2022.

CONCLUSIONS

The SERT scoring system proposed in this study will be unique and innovative because of its dynamic nature and modelling transparency. If successfully validated, our proposed solution will establish a standard for data processing and modelling by taking advantage of large-scale EHRs and interpretable machine learning tools.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/34201
Pulsed ultrasound for bone regeneration – outcomes and hurdles in the clinical application: a systematic review
Authors:   Berlin Institute of Health Centre for Regenerative Therapies, Charité-Universitätsmedizin, Föhrer Straße 15, 13353 Berlin, Germany, Puts R , Vico L , Beilfuß N , Shaka M , Padilla F , Raum K
Published: October 2021

Impaired bone-fracture healing is associated with long-term musculoskeletal disability, pain and psychological distress. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive and side-effect-free treatment option for fresh, delayed- and non-union bone fractures, which has been used in patients since the early 1990s. Several clinical studies, however, have questioned the usefulness of the LIPUS treatment for the regeneration of long bones, including those with a compromised healing. This systematic review addresses the hurdles that the clinical application of LIPUS encounters. Low patient compliance might disguise the effects of the LIPUS therapy, as observed in several studies. Furthermore, large discrepancies in results, showing profound LIPUS effects in regeneration of small-animal bones in comparison to the clinical studies, could be caused by the suboptimal parameters of the clinical set-up. This raises the question of whether the so-called “acoustic dose” requires a thorough characterisation to reveal the mechanisms of the therapy. The adequate definition of the acoustic dose is especially important in the elderly population and patients with underlying medical conditions, where distinct biological signatures lead to a delayed regeneration. Non-industry-funded, randomised, double-blind, placebo-controlled clinical trials of the LIPUS application alone and as an adjuvant treatment for bones with complicated healing, where consistent control of patient compliance is ensured, are required.
Emergency Architecture in Lebanon: the Gateway to what is required from us for the Future of Emergency Architecture
Authors: Jaber Arch. Nader
Published: October 2021

Abstract: Throughout the years, tents have dominated the scene when it comes to emergency architecture, what is the reason behind it? Many architects and engineers have tried to put forward alternatives, and even though many ideas were brilliant they have failed to overcome the dominance of tents. This fact question whether we should really try to give alternatives or whether all our efforts should be focused elsewhere? The following entangles this argument through a series of researches and site visits performed in Lebanon. Keywords: Emergency architecture, Phase II, refugee camps, refugee settlements, Lebanon, Syria, Palestine.
Seismic Analysis of Commercial Building with Grid/Waffle slab using ETABS
Authors: Pandey Anurag Kumar
Published: October 2021

Abstract: In This I have studied the seismic response of various types of slab in commercial buildings and their seismic behavior is studied. As we know every year uncountable number of earthquakes occur at different places, that means, small movements of tectonic plates occur all the time causing earthquakes. A seismic resistant designed building can provide safety for more people. slabs and roofs needed more columns if we design seismic resistant design but at some places like airport, shopping mall, commercial building more column can create some problem. To overcome this problem seismic design of grid slab or waffle slabs was comes out. Grid /Waffle slab consists of Concrete beams spaced at uniform intervals in perpendicular directions which are monolithically casted with slab and they are more safe in earthquake situation as comparison of to normal conventional slab. Keywords: Grid Slab, Earthquake Load , Response Spectrum , Storey Drift, Storey Displacement , E-Tab 2018 , Base Shear, Time Period , Mode Shapes.
Safety innovation resources in safety management: An empirical study in high-risk industries
Authors: Wang Guan , Zhou Xiaohu
Published: October 2021

We developed and tested a model linking safety innovation resources with safety innovation behavior and safety performance. Participants were 381 employees of blasting, chemical, mining, and other high-risk industries in China. Results show that safety innovation resources were positively
associated with safety innovation behavior and safety performance, and that safety innovation behavior played a partial mediating role in this relationship. In addition, leader–member exchange moderated the relationship between safety innovation resources and safety innovation behavior.
Our results provide a new theoretical perspective and empirical evidence for safety innovation behavior, and they are a valuable guide for leaders on how to promote safety innovation behavior.
THE IMAGE OF THE COLONIAL "OTHER": EAST TURKESTAN IN THE VIEWS OF THE BRITISH IN THE 1870s.
Authors:   Academician I.G. Petrovskii Bryansk State University (Russia), Bogomolova N.N.
Published: October 2021

The article reveals the mechanisms of the East Turkestan’s image representation which represented in British press during Kashgaria’s expedition of sir D. Forsythe - an official of the Anglo-Indian administration and the political Adviser on Central Asian Affairs. The theme fits into the problems of the image of the colonial "Other". The process of its formation is shown through the investigation of the textual and visual components of the East Turkestan’s image which represented in British press during the period. It is the analysis of the novation and continuity of metropolitan citizens’ perception of their colonies that is in the focus of our attention in the first mass illustrated magazine “The Illustrated London News” and such conservative press as “The Daily Telegraph”, “The Morning Post”, “The Standard”, “The Manchester Courier”, “The Leeds Intelligencer”. It is the analysis of specific stylistic means that helps to construct the image of the colonial "Other" on the pages of the British press. The author analyzes the peculiarities of the Victorians ' perception of the political titulature of East Turkestan, local residents, their appearance and personal qualities, natural conditions, cities, settlements, and features of everyday life.
MILES SHEROVER AS A SALES AGENT OF REPUBLICAN SPAIN IN THE UNITED STATES IN 1937-1938
Authors:   Lomonosov Moscow State University (Russia), Inviyaeva V.V.
Published: October 2021

The article describes the activities of Miles Sherover, an American entrepreneur, president of the Hanover Sales Corporation, who served as a sales agent of the Spanish Republic in the United States in 1937-1938. During the study period, M. Sherover, being authorized by the Government of the Second Republic, participated in a number of initiatives of the leadership of the Spanish Republic, such as Spanish-American negotiations on the security of the finances and property of American companies in Spain and the sale of silver reserves of the Bank of Spain to the United States in order to pay for the purchase of military equipment, civilian goods and raw materials with the proceeds. In addition to being as a middleman between the Spanish Republic and the United States in the trade, M. Sherover was actively engaged in political activities, the consequences of which discredited the Embassy of the Republic in Washington, as the Spanish Ambassador Fernando de los Rios, who was wary of the entrepreneur, regularly reported to the Prime Minister of the Spanish Republic Juan Negrin and Foreign Minister Julio Alvarez del Vayo. In general, the activities of Miles Sherover were contradictory: in order to help the Second Republic, he was engaged not only in issues of Spanish-American trade during the war, but also was carried out active political activities that went beyond his official powers and put the diplomacy of the Second Republic in the United States in a difficult position
ORIGIN OF HEAD CROWNS IN ANCIENT AESTIA AND PRUSSIANS
Authors:   Institute of Archeology of the Russian Academy of Sciences (Russia), Kulakov V.I.
Published: October 2021

The archaeological material of the south-eastern Baltic States contains several rare specimens of typeset head corollas for the antiquities of the Western Balts. The conclusions obtained as a result of the analysis of the head corollas of the Western Balts of the I-XIV centuries can be presented as follows: 1. Northern European masters at the beginning of our era created their own versions of head wreaths, based on examples of ancient votive wreaths. The latter were used both in triumphal events and at the burial of notable members of ancient society. It remains unclear under what conditions the Scandinavians could adopt the idea of a votive wreath, reworking it in the form of head corollas. 2. In phase B1, individual representatives of the northern tribes appear on Sambia, who brought crowns with them to the Amber Coast as part of the matrimonial "import", which were attached in especially solemn (cult ?) in cases of head covering. 3. In Roman times, head crowns did not find their place in the material culture of the population of the western outskirts of the Baltic world. In the early Middle Ages, through the mediation of master jewelers of south-eastern Europe, the tradition of wearing corollas made using Byzantine traditions spread in the Baltic States. It is possible that these traditions came to the Baltic States with groups of artisans along the Vislin trade route – the ancient Great Amber Road.
UNIVERSIDADE E INTERAÇÃO COM A SOCIEDADE: A PROPOSTA DOS CENTROS DE DESENVOLVIMENTO REGIONAL
Authors: Silva Dayanne Santos , De Santana José Ricardo , Rapini Márcia Siqueira
Published: October 2021

O objetivo deste trabalho é analisar se os projetos pilotos do Centro de Desenvolvimento Regional (CDR) apresentam características capazes de incrementar o papel da universidade na promoção do desenvolvimento regional, em comparação as ações tradicionais de extensão no país. O programa CDR foi proposto pelo Centro de Gestão e Estudos Estratégicos (CGEE), a partir de demanda do Ministério da Educação, CDR como uma ação universitária a ser desenvolvida na região onde está localizada a respectiva instituição. Atualmente a iniciativa é executada no formato de projetos pilotos. No estudo, a metodologia utilizada traz a caracterização da extensão universitária e da atuação do CDR, por meio de pesquisa documental e análise exploratória de dados. Os resultados indicam que o CDR possui potencial para trazer aspectos inovadores por meio da pesquisa científica, sendo assim uma ação de extensão voltada ao desenvolvimento regional que avança significativamente em relação ao modelo de extensão tradicional.
A REPRESENTAÇÃO DO ACUSATIVO NAS FORMAS DOS PARADIGMAS ‘TU’ E ‘VOCÊ’ EM CARTAS DE AMOR DO SÉCULO XX: DO LITORAL AO SERTÃO DE PERNAMBUCO
Authors: Ataíde Cleber , Antônia Caroline Alves da Silva  , Helder Aquino de Melo  , Alves da Silva Sheila Daniela
Published: October 2021

Neste artigo, buscamos analisar a representação do acusativo nas formas dos paradigmas tu e você nas cartas de amor do litoral e do sertão pernambucano. Tomamos como base os resultados alcançados em estudos prévios do Projeto Para a História do Português Brasileiro (PHPB), visando ampliar as pesquisas a partir do acervo documental de manuscritos pernambucanos dos séculos XIX e XX. O corpus selecionado constitui-se de 80 cartas de amor, sendo 40 cartas trocadas por um casal da região do litoral e 40 trocadas por um casal do sertão pernambucano. Para analisar o contexto morfossintático acusativo nas cartas pernambucanas, adotamos trabalhar com um grupo de fatores específicos, a fim de sistematizar a análise por meio da rodagem dos dados no programa Goldvarb X: tratamento na posição de sujeito, forma de representação, padrão de organização sintática, sexo, faixa etária, período, parentesco, localidade e subgênero. Nas análises, o quadro geral de uso dos acusativos evidenciou que os pronomes do paradigma de terceira pessoa - você no litoral e lhe no sertão - foram as estratégias predominantes nas cartas.  O clítico te, em ambas as localidades, foi a segunda estratégia mais utilizada pelos missivistas. No sertão foi computada uma ocorrência do clítico o/a, estratégia ausente no corpus litóreo. Esse panorama parece mostrar um movimento de “instabilidade-estabilidade” na função acusativa, uma vez que a partir da inserção da forma você no paradigma pronominal brasileiro, houve uma reorganização dos subsistemas em que formas de terceira pessoa podem ser predominantes (ainda que timidamente), mas que não conseguem excluir/minimizar o uso do clítico te nessa função.
A EXPERIÊNCIA SOCIAL DA LESBIANIDADE REPRESENTADA NO DRAMA AUTOBIOGRÁFICO-MEMORÍSTICO EM QUADRINHOS
Authors: Bezerra Fábio Alexandre Silva , Silva da Rocha Dias Thayse
Published: October 2021

Alison Bechdel é uma cartunista e memorista estadunidense, que publicou em 2013 sua segunda graphic memoir, intitulada Você é Minha Mãe? Um drama em quadrinhos, refletindo sobre suas relações, sua subjetividade e discutindo a sua própria identidade e sexualidade. Dessa forma, o objetivo central deste artigo é analisar como a artista representa a experiência da lesbianidade ao recriar as memórias da relação mãe-filha a partir da mobilização de recursos visuais e verbais. Para essa análise multimodal, tomamos como base o suporte teórico-metodológico proposto na gramática do design visual (KRESS; VAN LEEUWEN, 2006), enfatizando a metafunção representacional, em seus significados narrativos e conceituais a fim de analisar a representação da experiência social da lesbianidade. No tocante ao enquadramento crítico, adotamos conceitos desenvolvidos no artigo Compulsory Heterosexuality and Lesbian Existence (RICH, 1980) e no capítulo Lesbian Psychology (ELLIS, 2015). Os resultados da análise revelam a mobilização de recursos verbo-visuais na representação da experiência da sexualidade apontando para suas dimensões subjetiva e institucional, assim como processos de invisibilização e de opressão socialmente experienciados em função da lesbianidade.
[ID 57960] EVOLUÇÃO DA NOVA DOENÇA INFECCIOSA DO CORONAVÍRUS (COVID-19) NO BRASIL ATÉ A SEMANA EPIDEMIOLÓGICA 53 DE 2020
Authors: Bispo de Barros Francisco Railson
Published: October 2021

Objetivo: Caracterizar o perfil epidemiológico da COVID-19 no Brasil até a Semana Epidemiológica 53 de 2020. Metodologia: Trata-se de um estudo ecológico baseado em dados e documentos preexistentes do Ministério da Saúde brasileiro e órgãos de saúde internacionais, conduzido a partir de uma análise comparativa do Brasil, suas macrorregiões e unidades federativas, com os outros quatro países com maior número de casos e óbitos registrados, tendo sido calculadas as taxas de incidência e de mortalidade. Resultados: Ao final da semana epidemiológica 53, o Brasil registrou 7.716.405 casos, 195.725 óbitos e todos os municípios com registros oficiais da COVID-19. O Brasil estava em terceiro lugar em casos acumulados, atrás de Estados Unidos (19.806.654) e Índia (10.279.788), e em segundo em óbitos, após os Estados Unidos (342.830) e seguido da Índia (149.218). A macrorregião com as maiores taxas foi a Centro-Oeste (53.835,8/1 milhão). O Estado de Roraima apresentou a maior taxa de incidência do país (113.671,8/1 milhão) e o Estado do Rio de Janeiro a maior taxa de mortalidade (1.483,2/1 milhão). Conclusão: O Brasil se encontra em ampla disseminação da COVID-19, demonstrando crescimento e decréscimo regional em fases diferentes, especialmente, em contextos sociossanitários desfavoráveis, o que consequentemente reflete no maciço contágio, adoecimento e óbitos.
I-GROUP PRESENCE QUESTIONNAIRE: PSYCHOMETRICALLY REVISED ENGLISH VERSION
Authors: BERKMAN Mehmet İlker , ÇATAK Güven
Published: October 2021

I-group Presence Questionnaire (IPQ), which is used to evaluate the mediated experience of presence -especially for virtual reality applications- is originally developed in German and translated to several other languages. However, there is not any psychometric study for these translations including English version, except the Portuguese and Persian translations. We evaluated English translation of IPQ with 36 participants through 12 VR sessions with an overall of 432 samples. Using a partial least squares based factor analysis approach, the original 14-item set is trimmed into 11-items in order to achieve better psychometric qualities. In addition, a covariance based confirmatory factor analysis is executed to compare models. Several indices, even the conservative Cronbach’s alpha indicated that the subscales of 11-item version are reliable, but not the 14-item version. Eliminated items did not lead to a decrease in scales’ sensitivity to identify different levels of Realism, Spatial Presence and Involvement for different virtual environments. Although we provided evidence to remove the items which are identically worded and inversely coded that are causing measurement error, we suggest researchers to employ the 14-items but report the results for both 14-item version and 11-item version, until the psychometric qualities of IPQ in English is confirmed with a larger sample of participants.
Approach to Systemic Mastocytosis: A case series.
Authors: Dakhlia Ines , Boussetta Najah , Dakhlia Sinda , Guediche Nour , Sayhi Sameh , Louzir Bassem
Published: October 2021

Mast cells are found in bone marrow, blood, mucosal, and connective
tissues. They migrate into the loose connective tissue of all organs.
They play a major role in many physiologic processes however as
discussed in this article they can become an aggressive force which can
damage the natural biological balance
Input Trade and Service Industry Productivity Growth
Authors: Hsu Mike
Published: October 2021

In this paper, I address two questions: (1) Does reducing tariffs for manufacturing inputs affect productivity in service industries? (2) Does the effect of input trade liberalization differ for importers in service and manufacturing industries? To answer these questions, I used an establishment-level survey of Uruguayan service industries from 1998 to 2005, a period in which the country reduced its tariffs on manufactured products. I found that service establishments that import inputs from abroad experience a larger increase in productivity relative to non-importers when input tariffs are reduced. Furthermore, the effects of trade liberalization are as significant in the service industries as in manufacturing.
Constraint-based algorithm to estimate the line of a milling edge
Authors: Bator Marcin , Śmietańska Katarzyna
Published: October 2021

Each practical task has its constraints. They limit the number of potential solutions. Incorporation of the constraints into the structure of an algorithm makes it possible to speed up computations by reducing the search space and excluding the wrong results. However, such an algorithm needs to be designed for one task only, has a limited usefulness to tasks which have the same set of constrains. Therefore, sometimes is limited to just a single application for which it has been designed, and is difficult to generalise. An algorithm to estimate the straight line representing a milling edge is presented. The algorithm was designed for the measurement purposes and meets the requirements related to precision.
The asymmetric effects of currency devaluation in selected sub-Saharan Africa
Authors: Odionye Joseph , Chukwu Jude
Published: October 2021

Economic activities in many sub-Saharan African (SSA) countries have weakened
markedly in the last few years, with deterioration in trade balances,
increasing foreign reserve depletion, and exchange rate depreciation. This
situation has led to a call by the International Monetary Fund for more
flexible exchange rate adjustment and even currency devaluation to reverse
the economic downturn. This call for devaluation has generated controversy
among economists and policymakers in these countries and has revived the
need to study the effects of devaluation on economic output in SSA
countries. This study therefore examines the asymmetric effects of currency
devaluation as a policy shift on economic output between 1980 and 2019 in
six selected SSA countries, namely Ghana, Kenya, Tanzania, Mozambique,
Nigeria, and Malawi. The study employs the smooth transition regression
(STR) model to determine the relative asymmetric responses of economic
output to devaluation and nondevaluation regimes. The results of STR are
mixed, as devaluation asymmetrically impacts positively and significantly on
economic output in Ghana, Kenya, Tanzania, and Mozambique, but is
insignificant in the case of Nigeria and Malawi. This mixed result suggests
that the impact of currency devaluation on economic output differs across
countries depending on the structure and size of the economy, the nature of
goods produced, and the supportive policies in place, among other things.
The policy implication of the findings is that policymakers in various
countries should understand the peculiarity of core macroeconomic variables
in order to design and implement robust policies.
Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus
Authors: Liu Qing-Rong , Zhu Min , Zhang Pingbo , Mazucanti Caio H. , Huang Nicholas S. , Lang Doyle L. , Chen Qinghua , Auluck Pavan , Marenco Stefano , O’Connell Jennifer F. , Ferrucci Luigi , Chia Chee W. , Egan Josephine M.
Published: October 2021

Human insulin (INS) gene diverged from the ancestral genes of invertebrate and mammalian species millions of years ago. We previously found that mouse insulin gene (Ins2) isoforms are expressed in brain choroid plexus (ChP) epithelium cells, where insulin secretion is regulated by serotonin and not by glucose. We further compared human INS isoform expression in postmortem ChP and islets of Langerhans. We uncovered novel INS upstream open reading frame isoforms and their protein products. In addition, we found a novel alternatively spliced isoform that translates to a 74–amino acid (AA) proinsulin containing a shorter 19-AA C-peptide sequence, herein designated Cα-peptide. The middle portion of the conventional C-peptide contains β-sheet (GQVEL) and hairpin (GGGPG) motifs that are not present in Cα-peptide. Islet amyloid polypeptide (IAPP) is not expressed in ChP, and its amyloid formation was inhibited in vitro more efficiently by Cα-peptide than by C-peptide. Of clinical relevance, the ratio of the 74-AA proinsulin to proconvertase-processed Cα-peptide was significantly increased in islets from type 2 diabetes mellitus autopsy donors. Intriguingly, 100 years after the discovery of insulin, we found that INS isoforms are present in ChP from insulin-deficient autopsy donors.
Unusual Cutaneous Reaction at Site of Methotrexate Injection in Two Patients with Psoriasis and Psoriatic Arthritis
Authors: Sadoghi Birgit , Kränke Birger , Cerroni Lorenzo , Weger Wolfgang
Published: October 2021

Abstract is missing (Short communication)
Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
Authors: Vandikas Maria Siekkeri , Landin-Wilhelmsen Kerstin , Polesie Sam , Gillstedt Martin , Osmancevic Amra
Published: October 2021

High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and vitamin D-binding protein in patients with psoriasis. The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. A prospective observational study was performed, including 20 patients with psoriasis and 15 controls. Serum samples were analyzed for, among others, vitamin D metabolites, vitamin D-binding protein and highly sensitive C-reactive protein. Baseline levels of vitamin D-binding protein were higher in patients with self-reported arthropathy than in those without. After 24 weeks’ treatment, an improvement in psoriasis was noted, as was a decrease in highly sensitive C-reactive protein. Vitamin D-binding protein decreased in those with self-reported arthropathy. Higher baseline levels of vitamin D were associated with faster and greater improvement in psoriasis. Vitamin D-binding protein may have an inflammatory biomarker role.
Sistema de Información para el AGRO colombiano
Authors: Sáenz Agudelo Yuly Paulin , Jaramillo Villegas Carlos Andres , Posso Sabogal Carlos Enrique , Arango Armando
Published: October 2021

El Semillero de Investigación “Desarrollo de Software” formuló el proyecto de investigación Sistema de Información Agrícola (SIA), el cual tiene como objetivo desarrollar un sistema de información y aplicación móvil agrícola para la visualización de variables por medio de sensores (Humedad del suelo, Radiación solar global, Temperatura relativa, Humedad relativa, Temperatura del suelo y Precipitación de lluvia) con tecnologías de bajo costo. Este proyecto se encuentra en fase de pruebas (Hardware y Software) en el Centro de Diseño e Innovación Tecnológica Industrial del municipio de Dosquebradas, Risaralda, Colombia. Este sistema actualmente permite al usuario visualizar el comportamiento de las variables del cultivo, en tiempo real, por medio de gráficos lineales que son generados a partir de filtros (Nodo, Sensor y Rangos de Tiempo).
DISEÑO DE LA ESTRATEGIA DE CONTROL PARA EL ÁCIDO SULFHÍDRICO (H2S) CONTENIDO EN EL BIOGÁS EN UNA TORRE DE FILTRACIÓN
Authors: Rodríguez Ceballos Javier Enrique , Gutiérrez Marroquín William , López Sotelo Jesús Alfonso
Published: October 2021

En este artículo se presenta el diseño de la estrategia de control para la reducción de ppm de ácido sulfhídrico, presente en el biogás crudo, extraído de unos biodigestores, mejorando así las condiciones del biogás para ser utilizado en generación eléctrica. Ante la falta de acceso a la planta, se aprovecha la disponibilidad de unos datos del funcionamiento de la torre de filtración, y utilizando redes neuronales artificiales se obtiene un modelo del proceso. Se construye con este modelo un lazo de control PID, en Simulink, para determinar los parámetros de sintonía del controlador que permitan obtener el desempeño adecuado del proceso. Para desarrollar el programa de control en un autómata programable, se utiliza la aplicación TIA Portal de Siemens, implementando la estrategia de control en un PLC serie      S7-1500. Mediante intercambio de datos entre la aplicación TIA Portal y Simulink. a través de una aplicación OPC, se determina el comportamiento del proceso de acuerdo a las condiciones de diseño establecidas. Se diseña una interfaz gráfica de usuario, HMI, desde la cual el operario puede visualizar el estado del proceso o modificar algunas condiciones de su funcionamiento.
Logística hospitalaria: una revisión bibliográfica
Authors: Núñez Florián María Isabel , Sandoval Arciniegas Orlando De Jesús
Published: October 2021

Este artículo tiene como objetivo un análisis sobre la logística hospitalaria, para ello se utilizó la metodología de revisión sistemática de literatura. Presenta las principales áreas que componen al sistema de logística hospitalaria integral y se definen los principales desafíos que en esta materia enfrenta el sistema de salud en Colombia. A través de este artículo, se concluye que el diseño de un modelo logístico de calidad, es una herramienta fundamental para la optimización de recursos y la mejora continua de la calidad de la prestación del servicio de salud.
Panorama del técnico en peluquería
Authors: Morales Fuentes Nelson , Rojas Navarrete Fabiam Eduardo
Published: October 2021

El presente artículo realiza una reflexión sobre la normatividad actual de la peluquería en Colombia, para esto se tomó como referencia las leyes actuales, artículos científicos, así como periódicos, sitios web y revistas significativas para este fin. Partiendo de estos referentes se toman aspectos económicos, la oferta formativa, brechas y tendencias en la moda actual como insumo. Igualmente se realiza un ejercicio desde el cual se observa la peluquería en Colombia y sus posibilidades para un escenario futuro, teniendo en cuenta la normatividad actual; el marco económico de la peluquería; la formación; necesidades del sector; y algunas perspectivas para este sector
Aproximación de análisis en Determinantes Ambientales de la Salud presentes en comunidades de artesanos en Amazonas.
Authors: Ramírez Vanegas Leonardo Raúl
Published: October 2021

Objetivo: El presente artículo muestra los resultados de investigación sobre análisis de determinantes sociales y ambientales presentes en las comunidades de los kilómetros 6 y 11 de Leticia, Amazonas, a fin de proponer alternativas de intervención desde la óptica del programa Tecnólogo en Salud Ambiental y Seguridad Sanitaria. Materiales y métodos: El diseño de la investigación se basó en el analisis interpretativo de las variables identificadas en los determinantes propuestos por el MinSalud, a partir de la recolección de información por medio de observación y entrevistas a actores sociales y artesanos en las comunidades del Resguardo Uitoto y Comunidad de San José, y la posterior interpretación de narrativas comparadas con la teoría y otros estudios en el tema. Resultados y discusión: Los hallazgos identificaron una fractura en determinantes relacionados con fallas en articulación de programas estatales con la cosmovisión étnica, condiciones deficientes sanitarias y exposición a sustancias químicas en procesos productivos que pueden estar afectando la salud y el medio ambiente. Conclusiones: Existe una oportunidad de que el Centro de Formación desarrolle acciones de intervención interinstitucional entre sedes y entidades fortaleciendo la vigilancia comunitaria ambiental, el fortalecimiento participativo comunitario y la propuesta de planes de gestión ambiental.
Competencia intercultural en salud: herramienta clave para enfrentar retos en modelos de atención en salud
Authors: Ramírez Vanegas Leonardo Raúl
Published: October 2021

La inclusión de la competencia intercultural para el talento humano en salud, normada por el Ministerio de Salud y Protección Social exige que instituciones responsables, como el Servicio Nacional de Aprendizaje-SENA y sus instructores, comprendan el significado de interculturalidad en salud y su aplicación en el contexto formativo de los aprendices de diferentes programas, fortaleciendo competencias de intervención en comunidades con este tipo de características. Éste artículo tiene como objetivo reconocer los principales conceptos en el tema, contextualizar sobre la normatividad vigente e identificar los puntos principales sobre los cuales se debe construir el proceso de formación de la competencia. A través de la revisión de fuentes primarias, referentes teóricos y técnicos se hace una descripción de los aspectos más relevantes que se deben conocer para su aplicabilidad en procesos formativos. Este artículo de reflexión invita a conocer y profundizar sobre el tema, hacer uso del curso de formación complementaria diseñado y poder distinguir los puntos clave que se proponen desde los referentes técnicos que han profundizado en el tema.
Caracterización de la velocidad de desplazamiento en jugadoras de futsal del club Iraka de Sogamoso sub 17
Authors: Suarez Naranjo Javier Leonardo , Sanabria Arguello Yofre Danilo
Published: October 2021

El desarrollo de la velocidad de desplazamiento que integra la variable de velocidad de reacción, expresado mediante esta caracterización, busca establecer los niveles actuales de las deportistas y con ello realizar trabajos de mejora para lograr niveles óptimos de velocidad que permitan obtener posteriores beneficios en su rendimiento y función en el terreno de juego. El objetivo de la investigación es caracterizar la velocidad de desplazamiento en jugadoras de futsal del club IRAKA de Sogamoso sub 17. La metodología de investigación es abordada desde un estudio descriptivo, con enfoque cuantitativo y muestra intencionada, usando como instrumento de recolección de datos la plataforma Axon Jump 4.0 y su correspondiente software y el protocolo del test de Illinois con sus tablas de valoración. La población y muestra participante dentro del estudio fueron 24 jugadoras integrantes del club IRAKA, con promedio de edad de 17 años, valoración realizada en el mes de febrero del 2019, cuyos resultados reflejan el estado de las deportistas dentro del periodo de tiempo de la investigación en cuanto a la velocidad de desplazamiento, mediante la aplicación del test, evidenciando estadísticamente lo siguiente: ninguna deportista del club se encuentra en el rango de excelente según la valoración del test; el 4% de las deportistas se encuentran en un nivel sobre el promedio; el 54,1% en el nivel promedio, el 25% en un nivel de bajo promedio y finalmente el 16% en un nivel pobre. De acuerdo con el análisis se concluye que, el grupo objeto de estudio necesita de un trabajo específico para el mejoramiento de la velocidad de desplazamiento, teniendo en cuenta las características propias del deporte, lo cual implica el diseño de un plan de trabajo específico acentuado esta capacidad.
Análisis prospectivo para la identificación de acciones estratégicas del CFTHS en las ocupaciones técnicas y tecnológicas del sector salud y servicios personales
Authors: Ramírez García Yohana Milena , Torres Gil Astrid , Jojoa Mora Isabel
Published: October 2021

El artículo aborda la metodología desarrollada en el marco de la estrategia denominada “PREVIOS” (Sistema de prospectiva, vigilancia e inteligencia organizacional) establecida por el SENA a nivel nacional, con la finalidad de gestionar herramientas que le permitan mejorar la capacidad de anticipación y acierto en la toma de decisiones como fundamento del proceso de direccionamiento estratégico, con lo cual se posibilita el cumplimiento de su misión en el aporte a la productividad de las personas y las empresas del país. Esta iniciativa se encuentra estructurada en tres fases: a) Pre-prospectiva, con la focalización del proyecto y su definición de recursos para ejecución; b) Prospectiva, con el análisis y síntesis de conocimientos existentes para creación de escenarios y apuestas de futuro; y c) Post-prospectiva, con recomendaciones e implicaciones para la toma de decisiones. Para el caso del presente escrito solamente se abordará la fase Prospectiva. Objetivo: Presentar los lineamientos establecidos desde el Sistema de prospectiva del SENA PREVIOS y la aplicabilidad en el Centro de formación de talento humano en salud (CFTHS) en la primera fase pre-prospectiva. Metodología: En este artículo se describe la primera parte de la primera fase de la investigación desarrollada a partir de la aplicación de las prospectivas para el análisis de contexto interno y externo del CFTHS, se enuncian las generalidades de las vigilancias científicas, tecnológicas y competitivas para la construcción de un mapa de trayectoria determinando así los factores endógenos y exógenos del entorno con influencia directa para la toma de decisiones. Resultados: En primera instancia se realizó un análisis estratégico del entorno interno y externo; posteriormente se establecieron los lineamentos necesarios para la realizar las vigilancias científicas, tecnológicas y competitivas de todas las áreas temáticas del CFTHS teniendo como base las ocupaciones; finalmente se planificó el plan tecnológico como carta de navegación para la construcción del futuro mapa de trayectoria. Conclusiones: El desarrollo de la fase de pre-prospectiva permitió focalizar las áreas temáticas a las cuales pertenecen cada una de las ocupaciones impartidas en el centro de formación asociadas a la situación del sector salud y servicios personales para el crecimiento y el desarrollo institucional de tal forma que la proyección de la oferta educativa responda a las necesidades del futuro cumpliendo las expectativas del sector.
Siedziby pańskie na Śląsku w świetle źródeł pisanych. Studium nad średniowieczną nomenklaturą
Authors: Nowakowski Dominik
Published: October 2021

The subject of this study is the nomenclature used in medieval written sources for small feudal residences. The majority of them are private foundations of vassals to the duke, i.e., knights and citizens of Wroclaw. A few examples are seats of village administrators, as well as rural mansions of knightly orders. Also examined are smaller objects (most having special functions) built by territorial rulers – namely, Silesian dukes and bishops of Wrocław. These objects were clearly different in their scale from the stately brick castles that played the role of princely residences or were otherwise part of the country’s administrative structure. In light of the materials collected, small feudal residences were mentioned in medieval Silesian written sources as: curia/Hof, curia habitationis, curia murata/gemauerte Hof, castrum/Burg/Haus, fortalicium/Feste, propugnaculum/Bergfried, turris/Turm, Gesesse, Sitz, Rittersitz.
Historical and sociological analysis of the professional modernization process under conditions of online learning and digital transformation (case study of ASEAN countries)
Authors: Aramyan Karine , Krivopuskov Viktor
Published: October 2021

The purpose of the article is to analyze international experience in transforming the professional and qualification structure of ASEAN countries in the process of industrial policy modernization. The leading research method for this problem is historical-systemic and historical-sociological methods which allow for a complex analysis of the structure, functions, morphology and genesis of this process. The study presents a structural and functional model of transformation of professional and qualification structure of ASEAN countries during the period of economic modernization in 1967-1990, its role in the course and results of the industrial revolution in these countries and its further digital transformation. Practical significance: the results of the analysis allow assessing and using international experience in the implementation of methods of management of the national economy's human resource system under the conditions of FIR and transition from export-oriented industrialization to reindustrialization and digitalization.
Assessment of body mass index and resting metabolism of male sedentary and active older adults of Punjab, India
Authors: Kaur Pawandeep , Deol Nishan Singh
Published: October 2021

This study aimed to investigate the evaluation of body mass index and resting metabolism of sedentary and active elderly men from Punjab, India. Methods: Participants (N = 180) of the sedentary group (N = 90) and active group (N = 90) elderly people from Punjab were selected to act as study subjects. The study was delimited to sedentary and active male elderly, recruited between 60 and 70, 71 to 80 and 81 to 90 years, respectively. Results: The results of the studies in both variables found that there was a statistically significant difference in both variables with p-value of body mass index 0.02 (P <0.05) and p value of resting metabolism was 0.03 (P <0.05) of active and sedentary male elderly adults. Conclusion: In conclusion, the study revealed that, for people who practice moderate or vigorous physical activities, body mass index and resting metabolism change with aging.