bluuebunny/crossref_metadata_2025 huggingface dataset:
Costs and Scale-Up Costs of Community-Based HIV Self-Testing for Female Sex Workers and Men Who have Sex with Men in Jakarta and Bali, Indonesia
Authors: Putri Wayan Citra Wulan Sucipta , Ulandari Luh Putu Sinthya , Valerie Ivy Cerelia , Prabowo Bagus Rahmat , Hardiawan Donny , Sihaloho Estro Dariatno , Relaksana Riki , Wardhani Brigitta Dhyah Kunthi , Harjana Ngakan Putu Anom , Nugrahani Nur Wulan , Siregar Adiatma Yudistira Manogar , Januraga Pande Putu
Published: September 2023

Background.
The proportion of individuals who know their HIV status in Indonesia (66% in 2021) still remains far below the first 95% of UNAIDS 2030 target and were much lower in certain Key Populations (KPs) particularly Female Sex Workers (FSW) and Male having Sex with Male (MSM). Indonesia has implemented HIV Self-testing through Community-based screening (HIV CBS) in addition to other testing modalities aimed at hard-to-reach KPs, but the implementation cost is still not analysed. This study provides the cost and scale up cost estimation of HIV CBS in Jakarta and Bali, Indonesia.
Methods.
We estimated the societal cost of HIV CBS that was implemented through NGOs. The HIV CBS’s total and unit cost were estimated from HIV CBS outcome, health care system cost and client costs. Cost data were presented by input, KPs and areas. Health care system cost inputs were categorized into capital and recurrent cost both in start-up and implementation phases. Client costs were categorized as direct medical, direct non-medical cost and indirect costs. Sensitivity and scenario analyses for scale up were performed..
Results.
In total, 5350 and 1401 HIVST test kits were distributed for HIV CBS in Jakarta and Bali, respectively. Average total client cost for HIV CBS Self testing process ranged from US$1.9 to US$12.2 for 1 day and US$2.02 to US$33.61 for 2 days process. Average total client cost for HIV CBS confirmation test ranged from US$2.83 to US$18.01. From Societal Perspective, the cost per HIVST kit distributed were US$98.59 and US$40.37 for FSW and MSM in Jakarta andUS$35.26 and US$43.31 for FSW and MSM in Bali.
Conclusions.
CBS using HIVST approach varied widely along with characteristics of HIV CBS volume and cost. HIV CBS was most costly among FSW in Jakarta, attributed to the low HIV CBS volume, high personnel salary cost and client cost. Future approaches to minimize cost and/or maximize testing coverage could include unpaid community led distribution to reach end-users, integrating HIVST into routine clinical services via direct or secondary distribution and using social media network.
Elevated Tryptase Level in a Child with Idiopathic Anaphylaxis: A Case of Hereditary Alpha-Tryptasemia
Authors: Blanc Vicky Le
Published: September 2023

Hereditary Alpha-Tryptasemia (HαT) is an autosomal dominant disorder estimated to affect 5% of the population. High baseline tryptase level is a consistent finding, but there is a great variability of clinic manifestations, including no symptoms at all. We describe a case of HαT in a 5 years 8 months old girl manifesting with idiopathic anaphylaxis and elevated baseline tryptase level. As more cases of HαT are described, a better understanding of the clinical phenotype will be acquired.
Determinants of the use of public healthcare facilities for primary care of diabetes and hypertension in Urban Mysuru, India: a mixed-methods cross-sectional study 2022.
Authors: Verma Veenapani Rajeev , Ilangovan Kumaravel , Selvam Sumithra , Patil Gururaj , Kowlgi Ambuja , Malve Vidyacharan , Rajanna Yogendra Dommasandra , Chandrashekhar Sudha , DG Nagaraju , N Swaroop
Published: September 2023

Background
Noncommunicable diseases (NCDs) are one of the leading causes of morbidity and mortality in India. This study aimed to ascertain the individual, household, community, and health systems level factors influencing the demand of public healthcare network for primary management of diabetes and hypertension in a city in South India.
Methods
A mixed-methods cross-sectional study was conducted in Mysuru City, Karnataka. For quantitative inquiry, three-stage sampling strategies were followed and interviewed 6007 households comprising 2078/11978 (17.3%) individuals aged 30 and above with known diabetes or hypertension using structured questionnaires and different hierarchical levels of the workforce at 23 urban public health facilities. Andersen’s Behavioural Model of Healthcare Utilization, Multivariate logistic regression and Erreyger’s concentration indices were employed to unravel the socio-economic-demographic and contextual determinants driving the utilization of either public or private healthcare facilities for primary care of Diabetes and Hypertension. For Qualitative inquiry, we used multifarious techniques, such as a) four Key Informant Interviews (KII) conducted with policymakers at the state and city level with the help of semi-structured interview guides, b) 12 focus group discussions (FGDs) conducted with a homogenous group of respondents (men and women with diabetes and hypertension, frontline health workers and c) 36 In-depth Interviews (IDIs) d) 04 Public engagement workshops.
Results
The prevalence of diabetes and hypertension was greater in females (52.9% and 57.4%, respectively). More than two-thirds of surveyed population (68.4% and 64.6%) sought care for diabetes and hypertension from heterogeneous private providers. Socio-structural factors such as the level of education, occupation status, religion and caste, and individual characteristics such as living standards and insurance coverage (inverse and direct relationship, respectively) and facilities having high-technical and process quality scores and absence of multimorbidity impacted the likelihood of utilization of the public health system for management of diabetes and hypertension care. Erreyger's Indices established the inequality in access to public health facilities for treatments for both diabetes and hypertension among the poor.
Conclusion
The findings revealed a pervasive gap in the utilization of public health facilities for management of NCDs, by the urban poor despite the financial burden to seek care from private providers. Various demand and supply side recommendations can be propounded to augment the coverage and quality of public facilities for NCD management.
Comparison of Biomechanical Behavior Between Commercial and Patient-Specific TI6AL4V Titanium Plates of the Same Design Following Le Fort I Osteotomy: A 3D- Finite Element Analysis
Authors: Telha wael , Wang Qi , Al-Watary Mohammed Qasem , Sakran Karim , Chen Haozhe , Zhu Songsong , Jiang Nan
Published: September 2023

Background:Le Fort I osteotomy is a common orthognathic procedure for treating patients with midface skeletal abnormalities. This study evaluates and compares the biomechanical behavior between the three-dimensional (3D) printed patient-personalized TI6AL4V mini plates with commercially made pure mini plates of the same size and design using finite element analysis.Methods:Le Fort I osteotomy with 5 mm advancement associated with mediolateral rotation of the maxilla on the sagittal plane creating a gap of 3 mm at the most posterior part of the left side model was virtually executed on 3D-model using Mimics software. Fixation methods were modeled using (software) to represent 3D-printed patient-personalized TI6AL4V and commercially titanium mini plates. Both fixation mini plates models had the same conventional 4-hole L-shape design with similar thicknesses of 0.5 mm and 0.7 mm and placement vectors at the piriform rims and the zygomaticomaxillary buttress, respectively. ANSYS R19.2 software (Canonsburg, Pennsylvania, U.S.) was employed to create computer-aided engineering finite element models and analyses. Stress distribution, strain behaviors, and displacements of the fixation mini-plates, total model, and the maxilla segment were analyzed after loading postoperative occlusal force of 125, 250 and 500 N/mm².Results:Le Fort I fixation with TI6AL4V L-shaped mini plates resulted in lower principal VM stress, strain, and displacement values than commercially made titanium L-shaped mini plates. The TI6AL4V fixation demonstrated a reduced displacement of the maxillary segment. Both fixation models showed the maximum VM stress, strain, and displacement values across the area where a vertical gap between the bony segment of the maxilla was created due to the downward rotation creating a posterior gap of 3mm at the left side of the maxilla. The maximum overall VM stresses of TI6AL4V mini plates were relatively higher than those observed in the commercial titanium mini plates.Conclusion:The maximum stress, strain, and segment displacement of both fixation models were predominantly concentrated in the area of the vertical gap. Notably, both fixation materials exhibited remarkably close values, which can be attributed to the similar design of the fixation plates used in both models.
The detection of amyloid-β peptides in gingival crevicular fluid and its influence on oral pathogens
Authors: Liao Yue , Chen Huiwen , Qiu Che , Shen Hui , He Zhiyan , Song Zhongchen , Zhou Wei
Published: September 2023

Objective Periodontitis is the most prevalent oral inflammatory disease, contributing to the onset and progression of Alzheimer’s disease. However, the expression level of amyloid-β (Aβ) peptide in gingival crevicular fluid (GCF) and its effects on oral pathogens have not been studied adequately. This study aimed to analyze the expression level of Aβ peptides in GCF of periodontitis patients and the effects of Aβ peptides against common oral pathogens.Methods GCF samples were collected from patients with periodontitis (n = 15) and periodontally healthy people (n = 10). Four common oral pathogenic strains were used to evaluate the antibacterial effect of Aβ peptides via an MTT assay, Crystal Violet Staining, fluorescence microscope, and transmission electron microscope.Results The protein level of Aβ40 and Aβ42 in the GCF of periodontitis group was up-regulated compared with the healthy group. Both Aβ40 and Aβ42 exhibited antibacterial effects on Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Lactobacillus acidophilus in both planktonic and biofilm conditions. Further, Aβ40 showed an antibacterial effect on the biofilm of Fusobacterium nucleatum.Conclusions This study's findings demonstrate that Aβ peptides in GCF could be an indicator associated with the status of periodontitis. Further, the antimicrobial peptides derived from Aβ peptides have great potential in periodontal therapy.
Numerical analysis of brittle strength of welded pipelines with corrosion metal loss in transportation of blends of natural gas with hydrogen
Authors: Milenin Alexey , Velikoivanenko Elena , Rozynka Galina , Pivtorak Nina
Published: September 2023

As part of the analysis of the possibility of using the Ukrainian gas transportation system for transporting blends of natural gas and hydrogen, the peculiarities of the influence of hydrogen degradation of pipe steel on the brittle strength of girth welds and local corrosion metal losses were considered. For this, they were used the methods of finite-element modeling of the stress-strain state of structures during welding and subsequent operation loading along with advanced criteria of macroscopic fracture of a body with a crack. The results of predicting the safety factor for a typical welded part of a main gas pipeline with postulated surface cracks during the transportation of gas-hydrogen blends of various compositions showed that the most susceptible to brittle fracture are the weld metal and heat affected zone. But with regard to the fatigue strength of welded joints under the action of cyclic loading by internal pressure or bending moment, larger stress intensity factor ranges in the heat affected zone cause a more significant reduction of the residual safety factors. Local corrosion damage during the transportation of gas-hydrogen blends had a considerable negative impact on pipeline reliability, particularly when material properties experienced hydrogen degradation and a decrease in fracture toughness. However, this effect could be mitigated by adjusting the operating load accordingly.
Iron Metabolism-Related Gene Signatures for Predicting the Prognosis of Patients With Diffuse Large B-cell Lymphoma
Authors: Zhang Yuxin , Wang Yue , Cui Dawei , Wei Zheng
Published: September 2023

Background
Diffuse large B-cell lymphoma (DLBCL) is a common and highly aggressive type of lymphoma. Iron metabolism plays a critical role in various diseases, however, which remains completely unclear in patients with DLBCL. The aim is to explore the genetic characteristics and molecular mechanisms underlying iron metabolism in patients with DLBCL.
Methods
Based on the Gene Expression Omnibus (GEO) and the GeneCards database, weighted gene co-expression network analysis (WGCNA)was performed on the DLBCL sample (GSE83632) and Iron metabolism-related datasets to establish the gene co-expression network. Enrichment analysis was used to screen the key gene and analyze its expression and possible mechanism of action in patients with DLBCL.
Results
GATA1 was a key gene of iron metabolism in patients with DLBCL. It was related to the myeloid cell differentiation and granulocyte differentiation pathways to affect CD4 + T cells, B cells, and monocytes. GATA1 was also strongly positively correlated with sensitivity to multiple targeted drugs, like imatinib, nilotinib, and crizotinib, but negatively correlated with the PI3K inhibitor, and CDK9 inhibitor. The group with high GATA1 expression had higher overall survival and better prognosis than the group with low expression.
Conclusions
GATA1 is the first time to reveal the molecular mechanisms underlying the relationship between iron metabolism and DLBCL, suggesting that GATA1 is a significant biological target and immune-related biomarker of DLBCL.
The Variations in the Phytochemical Attributes of Nerium Oleander, Ricinus Communis, Calotropis Procera and Withania Somnifera From Three Ecological Zones of Pakistan
Authors: Khilji Sheza Ayaz , Tazeen Khola , Sajid Zahoor Ahmad , Akbar Khalid Farooq
Published: September 2023

The phyto-climatic diversity in a region presents the life form of vegetation. Plants produce vast and diverse variety of phytochemicals to communicate and minimize the climatic threats. In the current study, the variations in the phytochemical attributes of four plant species (Nerium oleander, Ricinus communis, Calotropis procera and Withania somnifera) from three ecological zones of Pakistan (sandy desert, irrigated & rain-fed plains) were investigated. The phenolic acids, flavonoids and tannins were quantitatively analyzed by methanolic extraction and standardized methods. The results revealed that zone rainfed lands and zone sandy desert showed the maximum amount of phytochemicals in all species and also exhibited the extreme environmental conditions. The irrigated plains had less stressful environmental condition and maximum amount of soil organic matter that resulted in minimum amount of phytochemicals in plant species. Previous research also supports the evidence that environmental stresses like temperature stresses, water stresses, high light intensities increase, and organic matter hinders the accumulation of phytochemicals. This study proved that same species in different ecological zones show different amounts of phytochemicals due to environmental variations, although environmental stresses exert the effects on plants to produce more phytochemicals.
Preoperative thrombocytosis is a predictor of poor prognosis in patients with resectable non-small-cell lung cancer: a retrospective randomized controlled study
Authors: wang bin , li zhupeng , zhu ting , ding Jianyi , zhang Jiandong , zhao junjun , yu guangmao , wang haiyong
Published: September 2023

Background:Operable non-small-cell lung cancer (NSCLC) has highly variable biological behavior. Blood markers cannot accurately predict its prognosis. Previous studies have shown that preoperative thrombocytosis is associated with poor prognosis in several cancers. The purpose of this study is to evaluate the prognostic significance of preoperative thrombocytosis in patients with NSCLC.Methods:We conducted a retrospective study on patients with NSCLC who underwent radical resection from May 2016 to December 2017. Platelet count was measured before each operation to evaluate the relationship between platelet count and clinicopathological factors and prognosis.Results:compared with patients with normal platelet count, patients with elevated platelet count had an increased risk of disease progression and death. The hazard ratio for disease progression was 1.585 (95% [CI] 1.159–2.166, P = 0.001), and the ratio for death was 1.385 (95% [CI] 1.041–1.843, P = 0.025).
Hydrogeochemistry and genesis of metasilicate spring water in the Changbai Mountain basalt area,NE
Authors: Su Yujuan , Yang Fengtian , Liang Xiujuan , Xiao Changlai
Published: September 2023

There have been many volcanic activities in the basalt area of Changbai Mountain, NE China is abundant in metasilicate spring water due to its unique geological conditions. This study analyzed the hydrochemical characteristics and genesis of the spring water based on analyses of water chemistry, water isotopes, SF6 and lithology of the volcanic rocks. Results show that the spring water is mainly recharged by local precipitation, with an elevation of 430.3-1033.5 m, then run along water conductive faults and discharges at low-lying areas as springs. The circulation depth of the groundwater is about 13–169 m, which is less than the thickness of the whole basalt layer, indicating that the groundwater circulation is limited to the basalt layer. The SF6 age of the spring water is around 8.5-35.0 a, indicating a rather fast flow rate. The main hydrochemical facies of the spring water is HCO3–Ca·Mg·Na, followed by HCO3–Na·Mg·Ca and HCO3–Mg·Na·Ca.Based on cross-plots of main chemical components, Pearson Correlation and Principle Component Analysis (PCA), the origin of the solutes in the groundwater and the main water-rock interactions are identified.
K2FeO4 modified biochar promotes the improvement of acid soil properties and the fixation of heavy metal ions in copper mines.
Authors: Zhang Xiao , Xue Jinchun , Han Huaqin , Wang Yu
Published: September 2023

A series of environmental pollution problems will occur in the process of copper sulfide mining, especially the acidification of mineral soil. In this study, a K2FeO4-biochar (Fe-BC) system was constructed by modifying biochar. Taking copper sulfide polluted acidic soil as the research object, aiming at the problems of low pH value, excessive heavy metals and insufficient organic matter content in soil, the organic-inorganic collaborative improvement method was adopted based on soil culture experiment. Under Fe-biochar system, the composite soil amendment has excellent effect on the improvement of mine soil characteristics polluted by Pb, Cu and Zn, and the fixation ability of heavy metal ions is enhanced. Fe-BC adsorption effect on Cu2+ Due to the original biochar (BC), the adsorption capacity increased by 44.96%. The quasi-second-order kinetic model and Langmuir model fit well (R2>0.98), indicating that the adsorption of Cu2+ is mainly monolayer surface adsorption and chemical adsorption. The surface properties and pore structure of Fe-BC before and after adsorption were characterized by Scanning Electron Microscope-Energy Dispersive Spectroscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. It was found that ferrate biochar has pore diffusion, electrostatic and complexation mechanisms on heavy metals, enhanced the solidification of heavy metals through reduction reaction.
The size effect and analogous boundary states in a periodic non-Hermitian chain
Authors: Ma Xin-Yu , Li Qiao-Nan , Guan Yi-Han , Qi Lu , He Ai-Lei
Published: September 2023

We investigate the size effect and boundary states based on a periodic non-Hermitian chain under the nonreciprocal intra-cell coupling and inter-cell coupling regimes. We find that the periodic non-Hermitian chain exhibits an even-odd effect of the unit cell corresponding to a large size of the chain, which is different from the open non-Hermitian chain only exhibiting the same effect for a small size of the chain. Moreover, we find that the originally localized bulk states become totally extended via designing the periodic coupling strength appropriately. The extended bulk states reveal the fact of the disappearance of non-Hermitian skin effect. Specially, we show that the periodic non-Hermitian chain also possesses the analogous edge states under some parameter regimes, which is pretty counterintuitive since the periodic chain usually cannot define a boundary. Our investigations supply the different non-Hermitian phenomena in a periodic non-Hermitian chain.
Vaginal microbiome differences between patients with adenomyosis with different menstrual cycles and healthy controls
Authors: Pan Zangyu , Dai Jun , Yuan Ming , Wang Guoyun , Zhang Ping , Ren Qianhui , Wang Xinyu , Yan Shumin , Hao Sun , Jiao Xue
Published: September 2023

Background
Adenomyosis is a commonly observed benign gynecological disease that affects the quality of life and social psychology of women of childbearing age. However, because of the unknown etiology and incidence of adenomyosis, its pathophysiological mechanism remains unclear; further, because no noninvasive, accurate, and individualized diagnostic methods are available, treatment and efficacy evaluations are limited. Notably, the interaction between the changes in the microecological environment of the female reproductive tract and human immunity, endocrine, and other links leads to the occurrence and development of diseases. In addition, the vaginal microbiome differs in different menstrual cycles; therefore, assessing the differences between the microbiomes of patients with adenomyosis and healthy individuals in different menstrual cycles will improve the understanding of the disease and provide references for the search for noninvasive diagnosis and individualized precision treatment of adenomyosis. This study aimed to explored the data of individuals in different menstrual cycles.
Results
Differences in the vaginal microbiome between patients with adenomyosis and healthy individuals were observed. At the phylum level, the relative abundance of Firmicutes species in the adenomyosis group was higher when compared with the control group. At the genus level, the relative abundance of Lactobacillus in the adenomyosis and control groups was the highest, which contributed the most to the species difference between the two groups. Alpha-diversity analysis showed significant differences in the adenomyosis and control group during luteal phase (Shannon index p = 0.0087, Simpson index, p = 0.0056). Beta-diversity analysis showed lower microbial richness in the adenomyosis group than that in the control group by weighted unifrac distance (p = 0.0018). In the same disease group, differences between different menstrual cycles were also observed. Finally, 50 possible biomarkers including were screened and predicted based on the PICRUSt.
Conclusions
The vaginal microbiome differs between patients with adenomyosis and healthy individuals during difference menstrual periods especially during the luteal phase. These findings facilitate the search for specific biological markers within a limited range and provide a more accurate, objective, and individualized diagnostic and therapeutic evaluation method for patients with adenomyosis than is currently available.
Differences in severity of chemotherapy-induced nausea and vomiting between neoadjuvant and adjuvant chemotherapy in patients with breast cancer: Analysis of data from two prospective observational studies
Authors: Son Kyung-Lak , Shin Joon Sung , Lee Sun Hyung , Lee Sungwon , Jung Saim , Kim Won-Hyoung , Jung Dooyoung , Kim Tae-Yong , Im Seock-Ah , Lee Kyung-Hun , Hahm Bong-Jin , Yeom Chan-Woo
Published: September 2023

We assessed the differences in chemotherapy-induced nausea and vomiting (CINV) severity in patients with breast cancer, receiving neoadjuvant chemotherapy (NAC) and adjuvant chemotherapy (AC). CINV in patients receiving anthracycline-based NAC (n = 203) and AC (n = 174) was assessed before chemotherapy (C0), after the first and fourth chemotherapy, using a 10-point Likert scale. Group-time interaction term used to assess if group effect on changes in CIN (cCIN) and CIV (cCIV) from C0 to follow-up are similar over time. If not significant, group effect was evaluated in model without interaction term. Subgroup analysis were performed a based on age 50. The effect of group by follow-up period was not significant. Adjuvant chemotherapy was associated with a significantly higher change in severity of cCIN than neoadjuvant chemotherapy in the group effect (estimated mean difference = 0.888, p = 0.013). The two groups differed significantly between the severity of cCIN in those aged ≤ 50 years (estimated mean = 1.151, p = 0.009) but not in those aged > 50 years. NAC for breast cancer patients shows less severe CIN than AC, but not in middle-aged and above. Clinicians should recognize that CIN severity may vary across chemotherapy settings and manage accordingly.
Joinpoint Regression Analysis of Recent Trends In Desmoplastic Malignant Melanoma Incidence And Mortality: 15-Year Multicentre Retrospective Study
Authors: Yu Hai , Zhu Linna , Zhang Jinrong , Zheng Suzheng , Ming Wai-kit , IP CHEONG CHEONG , Jiang Yuzhen , Chen Wenhui , Wu Shi , Lyu Jun , Deng Liehua
Published: September 2023

Background
Desmoplastic Malignant Melanoma (DMM) detection and mortality rates have significantly increased in recent years.There are currently no comprehensive epidemiological investigations of DMM incidence and mortality trends.This study aims to explain changes in DMM incidence and mortality during a 15-year term (2005–2019).
Methods
Data on DMM patients was sourced from the Surveillance, Epidemiology, and End Results (SEER) database. Both incidence and incidence-based mortality rates were directly extracted from the SEER database. Joinpoint regression was used to analyze and calculate the average annual percent change (AAPC) and its 95% confidence interval (CI).
Results
Between 2005 and 2019, 3,384 DMM cases were identified, boasting an age-adjusted incidence rate of 3.63% (95% CI: 3.51–3.76) and an incidence-based mortality rate of 1.65% (95% CI: 1.57–1.74). Of these, 2,353 were males (69.53%) and 1,031 were females (30.47%). There were 1894 patients (55.97%) who were over 70 years old. Predominantly, DMM lesions manifested in exposed areas: Limbs (955, 28.22%), Face (906, 26.77%), and Scalp and Neck (865, 25.56%). The incidence of DMM increased significantly at a rate of APC = 0.9% during 2005–2019, while the incidence-based mortality showed a significant upward trend (APC = 7%) during 2005–2012, and slowly increasing trend (APC = 0.6%) during 2012–2019. In contrast to the modest upward trajectory in female incidence and mortality, male incidence initially surged, later declining, while male mortality peaked and stabilized post-2012. The primary sites for incidence and mortality were consistently exposed areas: Face, Scalp and Neck, and Limbs.
Conclusions
In recent years, the incidence and incidence-based mortality of DMM have significantly increased. Each subgroup analysis has different trends, and these trends can provide better support for our exploration of DMM.
Structure and Protein-ligand Binding Studies of Pheromone Binding Protein-like Sol g 2.1 Protein from Solenopsis geminata Fire Ant Venom
Authors: Nonkhwao Siriporn , Plettner Erika , Daduang Sakda
Published: September 2023

Sol g 2 is the major protein in Solenopsis geminata fire ant venom. It shares the highest sequence identity with Sol i 2 (S. invicta), and shares high structural homology with LmaPBP (pheromone binding protein (PBP) from the cockroach, Leucophaea maderae). We examined the specific Sol g 2 protein ligands from the fire ant venom. The results revealed that the protein naturally formed complexes with hydrocarbons, including decane undecane, dodecane, and tridecane, in aqueous venom solutions. We found that decane has a higher affinity binding with the recombinant Sol g 2.1 protein (rSol g 2.1) than other specific ligands. Surprisingly, the mixture of the alkanes showed higher binding affinity with rSol g 2.1 protein than any single one, a positive blend effect. The ligands were examined further by molecular docking simulations, which showed allosteric binding sites in the Sol g 2.1 protein model. We also performed a trail-following bioassay and found that rSol g 2.1 and the mixture of hydrocarbons elicited S. geminata worker ants to follow the trails for a longer time and distance than only a mixture of hydrocarbons, which suggests that Sol g 2.1 protein may delay the evaporation of the hydrocarbons. Interestingly, the fully reconstituted venom, which contained piperidine alkaloids and trail pheromones, has the highest attraction to the ants. Therefore, the mixture of hydrocarbons and the piperidines have a synergistic effect on the trail-following of the ants when both were added to the protein.
Transcriptome analysis reveal alterations in hepatic glycan biosynthesis and metabolism of grass carp (Ctenopharyngodon idellus) fed with broad beans
Authors: Hao Meilin , Zhu Junhong , Xie Yuxiao , Cheng Wenjie , Yi Lanlan , Zhao Sumei
Published: September 2023

The meat of grass carp (Ctenopharyngodon idellus) fed broad beans is crispy, called crisp grass carp. In order to better understand the changes mechanistic in liver tissue of crisp grass carp, gene expression profiles and pathways of liver tissues were performed by using RNA-seq. As a result of the transcriptome analysis, the total number of reads produced for each liver sample ranged from 35,914,404 to 42,460,834. A total of 2519 differentially expressed genes (DEGs) were identified. Among them, 1156 genes were up-regulated and 1363 genes were down-regulated. Gene Ontology (GO) annotations indicated that DEGs were mainly enriched in biological processes of ribosome and structural constituent of ribosome. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis revealed that DEGs were mainly enriched in metabolism of energy, amino acid, carbohydrate, and lipid acid, and the genes in these pathways were up-regulated. The protein-protein interaction (PPI) network with 260 nodes and 249 edges was constructed and 3 modules were extracted from the entire network. ITML, STT3B, SEL1L, UGGT1, MLEC, IL1B, ALG5, KRTCAP2, NFKB2, IRAK3 genes were the top 10 hub genes with the closest connections to other nodes. In summary, this study identified several candidate genes and focused on glycan biosynthesis and metabolism pathways, providing a reference for further investigation into the mechanism of liver metabolism in grass carp fed with broad beans.
wildNeRF: Novel view synthesis of in-the-wild dynamic scenes using sparse monocular data
Authors: Khalid Shuja , Rudzicz Frank
Published: September 2023

We present a novel neural radiance model that is trainable in a self-supervised manner for novel-view synthesis of dynamic unstructured scenes. Our end-to-end trainable algorithm learns highly complex, real-world static scenes within seconds and dynamic scenes with both rigid and non-rigid motion within minutes. By differentiating between static and motion-centric pixels, we create high-quality representations from a sparse set of images. We perform extensive qualitative and quantitative evaluation on existing benchmarks and set the state-of-the-art on performance measures on the challenging NVIDIA Dynamic Scenes Dataset.
Additionally, we evaluate our model performance on challenging real-world datasets such as Cholec80 and SurgicalActions160.
Improved neurological outcome of perampanel for hypoxic-ischemic encephalopathy in patients after out-of- hospital cardiac arrest resuscitation
Authors: Nakamichi Yoshimi , Ichibayashi Ryou , Watanabe Masayuki , Suzuki Ginga , Serizawa Hibiki , Yamamoto Saki , Masuyama Yuka , Honda Mitsuru
Published: September 2023

Purpose
Although the resuscitation rate for patients with out-of-hospital cardiac arrest (OHCA) in Japan is increasing due to the widespread use of automated external defibrillators (AEDs), the proportion of patients who can return to society remains low at approximately 7%. Many patients have poor neurological outcomes and cannot return to society because of post-resuscitation hypoxic-ischemic encephalopathy. While the resumption of cardiac rhythm is important for patients with OHCA, improving neurological outcomes and returning to society are also important. However, temperature management therapy has been introduced to improve neurological outcomes. This study investigated whether perampanel, an antiepileptic drug that provides neurological protection against stroke and head injury, could improve neurological outcomes in patients resuscitated after OHCA.
Methods
The participants included 33 patients with OHCA admitted to our hospital from January 2021 to June 2022 and 33 patients admitted before that time. Perampanel was administered to the patients in the intervention group immediately after resuscitation. We defined a Cerebral Performance Category (CPC) score of 1.2 as a good neurological outcome.
Results
There was no significant difference in neurological outcomes at intensive care unit (ICU) discharge between the intervention and non-intervention groups; however, neurological outcomes at hospital discharge were significantly better in the intervention group (P = 0.01).
Conclusion
The α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor inhibitory and neuronal protective effects of perampanel may have inhibited the progression of hypoxic-ischemic encephalopathy, which develops after the resumption of cardiac rhythm, and suppressed neuronal damage. Early administration of perampanel after resuscitation of patients with OHCA may improve neurological outcomes.
LGEQRE: Learning Guided Enumerative Synthesis for Query Reverse Engineering
Authors: Wang Huixian , Dou Quansheng , Tang Huanling , Pan Hao , Zhang Shun
Published: September 2023

To address the problem of users' lack of SQL query writing skills, Query Reverse Engineering (QRE) was proposed, where the goal of QRE is to generate a SQL statement based on a given database and query output table. SQUARES is one of the state-of-the-art models in the field, which enumerates constraint-compliant programs using a solver-based enumerator, and since the Solver randomly enumerates candidate programs, SQUARES synthesis is not very efficient. In this paper, we propose LGEQRE based on SQUARES, a learning-based approach to guide the enumeration of candidate programs. LGEQRE predicts the operators be required by neural network, sorts and deletes operators based on the prediction, and uses an Optimizer-based enumerator to enumerate programs according to the predicted probability of the operators. Under the same experimental conditions, the experimental results showed that LGEQRE increased the synthesis rate from 80% to 89.1% and reduced the average synthesis time from 251s to 117s compared to SQUARES.
Postpartum Antiphospholipid Antibody Syndrome Secondary to Sjögren's Syndrome Accompanied by Cerebral Venous Sinus Thrombosis and Multicompartmental Intracerebral Haemorrhage: A Case Report and Literature Review
Authors: Ma Dan , Han Jianhong , Li Chunyan , Zhang Jie , yuan yong , Bao Tianhao
Published: September 2023

Background: Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular disease that can be caused by various factors, including postpartum, pregnancy, autoimmune disorders, infections, and coagulation abnormalities. Sjögren's syndrome (SS) is an inflammatory autoimmune disease characterized by lymphocytic infiltration of exocrine glands.We report a case of a 27-year-old female diagnosed with postpartum antiphospholipid antibody syndrome (APS) secondary to SS and accompanied byCVST, subdural haematoma (SDH), intracerebral haemorrhage (ICH), and subarachnoid haemorrhage (SAH).
Case presentation: The patient is a 27-year-old female who was diagnosed with APS secondary to SS during pregnancy.She developed headaches 7 days postpartum and experienced seizures along with left-sided limb paralysis on the 9th day.Computed tomography (CT)and magnetic resonance imaging (MRI) scans indicated SDH,ICH and SAH.Magnetic resonance venography (MRV) suggested the formation of venous sinus thrombosis.The patient showed significant improvement after receiving anticoagulants, steroids, and immunosuppressive treatment.
Conclusions: The occurrence of APS secondary to SS and simultaneous CVST, along with SAH, ICH, and SDH, is exceedingly rare.However, in patients previously diagnosed with APS who experience neurological deficits, the possibility of CVST should be considered, and MRV examination should be promptly completed.The simultaneous occurrence of intracranial haemorrhage and thrombosis made the treatment of this patient complex. We summarized the pathogenesis, clinical features, treatment, and prognosis of this patient and then performed a literature review to provide clinical practitioners with a reference for the diagnosis and treatment of this disease.
Persistent DWI-PWI Mismatch Prediction: A Preliminary Study with Two-dimensional Texture Analysis Based on ADC maps
Authors: Long Miaomiao , Shrestha Apurwa , wu Yalin , Liu Lihua , Ma Xifeng , Yin Jianzhong
Published: September 2023

MR DWI-PWI mismatch has been established as a reliable biomarker for ischemic penumbra in acute ischemic stroke(AIS) patients. Texture analysis has demonstrated its ability to predict DWI-PWI mismatch of AIS within 24 hours. The current study was to investigate whether texture analysis of diffusion ADC maps can predict the existence of the DWI-PWI mismatch in the delayed imaging AIS patients. MR diffusion ADC maps of 82 patients with acute cerebral infarction beyond 24 hours from ischemic stroke onset were analyzed (41 with DWI-PWI mismatch and 41 without DWI-PWI mismatch). 2D Texture features were extracted to develop models for predicting the existence of DWI-PWI mismatch. 30 texture features were selected with the texture analysis software, and reduced to 10 with Lasso method and 3 with stepwise logistic regression. An equation was developed with these three features with acceptable diagnostic performance (sensitivity: 80.5%(65.1%~91.2%, specificity: 75.6%(59.7%~ 87.6%), PPV: 76.7%(61.4%~88.2%), NPV 79.5%( 63.5%~90.7%), AUC: 0.859(0.777~0.941), misclassification rate: 21.95%). During the leave-one-out validation, the equation is relatively stable, with 4 case changed the predicted status. 2D texture analysis of diffusion ADC maps can be used to predict the existence of DWI-PWI mismatch in the delayed imaging population. The logistic regression-based equation is a promising predicting method.
A Trinomial Difference Autoregressive Model for the Bounded Z-valued time series
Authors: Chen Huaping
Published: September 2023

This paper considers the autoregressive modeling problem of the bounded $\mathbb{Z}$-valued time series of counts,but little literature discusses this question.To fill this gap, we propose the trinomial difference bounded $\mathbb{Z}$-valued autoregressive (TDBZAR) model for bounded time series based on the trinomial difference thinning operator,and give some stochastic properties.An attractive merit of the TDBZAR model is thatthe incorporated trinomial difference thinning operatornot only makesthe conditional expectation take a linear form,but also makes its 1-step transition probability can be written as the convolution of two independent trinomial difference distribution,which makethe conditional least squares (CLS) estimateand conditional maximum likelihood (CML) estimate more wieldy and easy.Second, we discuss the two-step CLS estimate and CML estimate,establish their asymptotic properties of the estimators.Third, we apply the proposed model to a real data set.\\
Comprehensive identification of potentially functional genes for transposon mobility in the C. elegans genome
Authors: Arata Yukinobu , Jurica Peter , Parrish Nicholas , Sako Yasushi
Published: September 2023

Transposons are mobile DNA elements that encode genes for their own mobility. Whereas transposon copies accumulate on the genome during evolution, many lose their mobile activity due to mutations. Here, we focus on transposon-encoded genes that are directly involved in the replication, excision, and integration of transposon DNA, which we refer to as “transposon-mobility genes”, in the Caenorhabditis elegans genome. Among the 62,773 copies of retro- and DNA transposons in the latest assembly of the C. elegans genome (VC2010), we found that the complete open reading frame structure was conserved in 290 transposon-mobility genes. Critical amino acids at the catalytic core were conserved in only 145 of these 290 genes. Thus, in contrast to the huge number of transposon copies in the genome, only a limited number of transposons are autonomously mobile. We conclude that the comprehensive identification of potentially functional transposon-mobility genes in all transposon orders of a single species can provide a basis of molecular analysis for revealing the developmental, aging, and evolutionary roles of transposons.
The metabolic subtypes of gastric cancer reveal treatment preferences
Authors: Zhou Qi , Yuan Yiwu , Yue Zhenqi , Lu Hao , Liu Zhiyang , Sheng Jie , Xin Lin
Published: September 2023

Background
Understanding the details of gastric cancer metabolic reprogramming is crucial for improving stratified therapy.
Methods
By utilizing multi-omics data, we investigated metabolic dysregulation in gastric cancer and identified three distinct metabolic subtypes.
Results
These subtypes exhibited different prognoses, molecular subtype distributions, and genomic alterations. The metabolic subtypes displayed varying vulnerabilities to chemotherapy, with the C3 subtype being associated with chemotherapy resistance. The C2 subtype showed a preference for immune checkpoint therapy, while C3 subtype may have a better response to targeted natural killer (NK) cell receptor KLRD1 therapy. We discovered and confirmed the pro-cancer role of secreted SPP1 from macrophages through the SPP1/CD44 axis acting on cancer cells.
Conclusions
Collectively, we have discovered that patients with different metabolic subtypes exhibit treatment vulnerabilities to chemotherapy and various immunotherapies.
Implementing the Earned Income Tax Credit: shall governments design an employee or an employer-based system?
Authors: Strawczynski Michel
Published: September 2023

In this paper I use a labor market equilibrium model and a social welfare analysis for comparing between an employee-based EITC and an employer-based system. Since the labor supply of the low-wage workers is relatively rigid, firms enjoy market power that might be used in detriment of the policy-maker's goals when implementing an EITC system. While the employee-based system avoids coordination among firms, and thus reduces their market power, an employer-based system allows for automatic take-up at the initial stage of the program's implementation, which constitutes an advantage. These pros and cons in both systems shall be weighted one against the other; for that purpose, I run simulations using empirically plausible parameters taken from data of countries that implemented an EITC. The simulations show that in terms of social welfare the employee-based EITC tends to dominate the employer-based system.
JEL Numbers– H21, H24 and I38.
Dynamic Modelling of Risks Related to Central Bank Digital Currencies: An Analysis of Uncertainties for Banking System Stability
Authors: Brice M’bakob Gilles , Tchounga Anatole
Published: September 2023

This study aims to design a dynamic model to assess the potential impact of CBDC issuance on banking system stability. The study results show that overconfidence of economic agents towards CBDCs can drastically reduce bank reserves, thereby limiting the lending capacity of banks and creating liquidity problems. Similarly, increasing reserve requirements in fiat currency for each unit of CBDC issued can constrain bank reserves and restrict loans and deposits. Additionally, a rise in interest rates on CBDC-related loans can discourage borrowers, thereby reducing loan demand and affecting banking activity. An increase in interest rates leads to a decrease in the quantity of CBDC in circulation, an increase in bank reserves and deposits in CBDC, and a decrease in bank loans. Monitoring the level of confidence of economic agents towards CBDCs is crucial to avoid excessive speculation.
Properties of Fiber Cement Reinforced With Cellulose Pulp Modified by Plasma Treatment With Sulfur Hexafluoride (SF6)
Authors: SCHIAVI LAÍS SALVIANO DE OLIVEIRA , GONÇALVES MATEUS AQUINO , SILVA ADRIANA DE OLIVEIRA DELGADO , RANGEL ELIDIANE CIPRIANO , RAMALHO TEODORICO CASTRO , MENDES RAFAEL FARINASSI , VAZ LÍVIA ELISABETH VASCONCELLOS DE SIQUEIRA BRANDÃO
Published: September 2023

Cellulose pulp in cementitious matrix has been investigated due to its high tensile strength, which improves the mechanical properties of the composites. However, its high hydrophilicity is harmful to this kind of materials and may result in a reduction in the material's durability. In this work, to improve the matrix/reinforcement interaction in fiber cement, the surface of the cellulose pulp was modified by means of plasma treatment with sulfur hexafluoride (SF6). Fiber cement composite was produced from treated pulps. Fourier transform infrared spectroscopy, Raman spectroscopy as well as X-ray diffraction and scanning electron microscopy techniques were used to characterize the cellulose pulp. Theoretical calculations were developed to simulate the interaction of treated pulp and cementitious matrix and suggested the interaction of hydrogen between the molecules. There was a reduction in moisture absorption in the cellulose pulp. Cement-cellulose compatibility was adequate. The best results were obtained for the treatment with 0.10 Torr SF6.
Clinical and pathological characteristics of completely endophytic renal cell carcinoma
Authors: Zhu Zhenjie , Lou Jianmin , He Yedie , Zhu Shaoxing , Chen Jinchao
Published: September 2023

ObjectiveCompletely endophytic renal cell carcinoma (CERCC) is surrounded by non-tumoral renal parenchyma. This study aimed to compare the presentation, pathology, treatment, and outcomes of patients with CERCC or non-CERCC (NCERCC).Materials and MethodsData from patients with localized RCC were retrospectively collected from January 2009 to March 2022. They were classified as CERCC or NCERCC according to the location of the tumor in the kidney. A total of 67 cases of CERCC and 813 cases of NCERCC were included.ResultsCERCC accounted for 7.6% of all localized RCC. For patients with CERCC, the mean age was 58.5 years old, 59.7% (40/67) of the patients were male, and 20.9% of the patients presented with symptoms that were not significantly different from those with NCERCC. Pathologically, CERCCs were smaller (2.9 vs. 4.4, P<0.001) and had an earlier stage than NCERCCs. There was a significant difference in the distribution of pathological types between the two groups. However, the distribution of the pathological grades showed no significant differences. During the median follow-up period of 52 months, patients with CERCC tended to live longer than those with NCERCC (p=0.118).ConclusionCERCC is a renal tumor with a special location and differs in terms of tumor size, stage, pathology, and prognosis with NCERCC.