bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical reaction and diffusion kinetics during laser-induced submillisecond heating for lithographic applications
Authors: Jiang Jing , Jung Byungki , Thompson Michael O. , Ober Christopher K.
Published: June 2019

Reactions in solid-state chemistry are controlled by both underlying chemical reaction rates and temperature-dependent diffusion of reactants and products. Due to distinctly different activation energies, the relative rates of reaction and diffusion may shift dramatically with temperature. In this work, the acid catalyzed deprotection of acid labile groups of model chemically amplified photopolymers was studied to understand the effects of temperature on diffusion-coupled reactions. In these systems, strong acids form during exposure of photoacid generators (PAGs) to ultraviolet radiation and then diffuse and catalyze deprotection reactions. By using very short duration laser-induced heating for the postexposure bake step, the potential reaction temperature range is extended by several hundred degrees compared to traditional thermal processing temperatures. Thermal degradation at these temperatures is avoided by simultaneously reducing the heating time from minutes to submilliseconds. Both diffusion and reaction rates were measured in this high temperature region for three different photoresists combined with two different PAGs, with activation energies of the key processes determined. The interplay of diffusion and reaction rates was also examined by comparing results of high-resolution pattern formation. The best image formation at high temperature was achieved using photoresists with high deprotection rates combined with PAGs exhibiting low diffusivity.
A new dynamical systems perspective on atmospheric predictability: Eastern Mediterranean weather regimes as a case study
Authors: Hochman Assaf , Alpert Pinhas , Harpaz Tzvi , Saaroni Hadas , Messori Gabriele
Published: June 2019

Dynamical systems metrics provide an informative qualitative estimate of eastern Mediterranean weather regimes predictability.
Increasing mitigation ambition to meet the Paris Agreement’s temperature goal avoids substantial heat-related mortality in U.S. cities
Authors: Lo Y. T. Eunice , Mitchell Daniel M. , Gasparrini Antonio , Vicedo-Cabrera Ana M. , Ebi Kristie L. , Frumhoff Peter C. , Millar Richard J. , Roberts William , Sera Francesco , Sparrow Sarah , Uhe Peter , Williams Gethin
Published: June 2019

Increasing climate commitments to meet the Paris Agreement goal avoids large numbers of heat-related deaths in U.S. cities.
Raising fluid walls around living cells
Authors: Soitu Cristian , Feuerborn Alexander , Deroy Cyril , Castrejón-Pita Alfonso A. , Cook Peter R. , Walsh Edmond J.
Published: June 2019

Microfluidics with fluid walls opens up the realm of reconfiguring cellular environments during assays.
Touch as an auxiliary proprioceptive cue for movement control
Authors: Moscatelli A. , Bianchi M. , Ciotti S. , Bettelani G. C. , Parise C. V. , Lacquaniti F. , Bicchi A.
Published: June 2019

Cutaneous stimuli from contact with objects provide auxiliary proprioceptive feedback for guiding actions.
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease
Authors: Sun Yongzhan , Liu Zhiheng , Cao Xinyi , Lu Yi , Mi Zeyun , He Chaoran , Liu Jing , Zheng Zhanye , Li Mulin Jun , Li Tiegang , Xu Dechao , Wu Ming , Cao Ying , Li Yuhao , Yang Baoxue , Mei Changlin , Zhang Lirong , Chen Yupeng
Published: June 2019

P-TEFb activation by cAMP-PKA signaling promotes cystogenic gene transcription elongation and disease progression in ADPKD.
EF-G–induced ribosome sliding along the noncoding mRNA
Authors: Klimova M. , Senyushkina T. , Samatova E. , Peng B. Z. , Pearson M. , Peske F. , Rodnina M. V.
Published: June 2019

Translational translocase pushes hyper-rotated ribosomes to slide along the noncoding mRNA gap at the cost of GTP hydrolysis.
High-throughput mapping of CoA metabolites by SAMDI-MS to optimize the cell-free biosynthesis of HMG-CoA
Authors: O’Kane Patrick T. , Dudley Quentin M. , McMillan Aislinn K. , Jewett Michael C. , Mrksich Milan
Published: June 2019

A chemical approach enables the rapid mapping of CoA metabolites in complex biological systems.
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology
Authors: Gerez Juan A. , Prymaczok Natalia C. , Rockenstein Edward , Herrmann Uli S. , Schwarz Petra , Adame Anthony , Enchev Radoslav I. , Courtheoux Thibault , Boersema Paul J. , Riek Roland , Peter Matthias , Aguzzi Adriano , Masliah Eliezer , Picotti Paola
Published: June 2019

An iron-regulated ubiquitin ligase targets exogenous α-synuclein for degradation and counteracts Lewy body–like pathology in preclinical models.
A bit too much Olig2 in Down’s syndrome
Authors: Yang Ming
Published: June 2019

Overproduction of the Olig2 gene responsible for cerebral cortex neurotransmission may explain cognitive impairment in Down’s syndrome.
Quaternary coral reef complexes as powerful markers of long-term subsidence related to deep processes at subduction zones: Insights from Les Saintes (Guadeloupe, French West Indies)
Authors: Leclerc Frédérique , Feuillet Nathalie
Published: June 2019

Geodetic measurements reveal modern rates of tectonic deformation along subduction zones, but the kinematics of long-term deformation are typically poorly constrained. We explore the use of submarine coral reefs as a record of long-term coastal vertical motion in order to determine deformation rate and discuss its origins. The Lesser Antilles arc results from the subduction of the American plates beneath the Caribbean plate and undergoes regional vertical deformation. Uplifted reefs along forearc islands are markers of the interplay between tectonics and sea-level variations since the late Pleistocene. We compared results from a numerical model of reef-island profile development to high-resolution marine geophysical measurements of Les Saintes reef plateau (Guadeloupe, French West Indies), a ∼20-km-wide, 250-m-thick submerged platform that lies at 45 m below sea level along the volcanic arc, to constrain its vertical deformation history. Models explore different scenarios over wide parameter domains including start time, basement morphology, sea level variations, reef growth rate, subaerial erosion rate, and vertical motion history. The major features of the plateau (its depth, internal structure, unusual double-barrier) is only reproduced in a context of subsidence, with a constant rate of −0.3 to −0.45 mm/yr since the late Pleistocene, or in a context of increasing subsidence, presently of ∼–0.2 mm/yr. Discussed in the framework of the forearc vertical deformation history, this result indicates subsidence is promoted by local faulting, volcanic, and deep subduction processes. Coseismic deformation accumulation could be a mechanism by which deformation builds up in the long-term. We show that subduction can drive long-term subsidence of a volcanic arc, and demonstrate that submarine reefs are powerful markers of long-term vertical motion.
Cascade of immunologic adverse events related to pembrolizumab treatment
Authors: Dhenin Arnaud , Samartzi Vassiliki , Lejeune Sarah , Seront Emmanuel
Published: June 2019

Immune checkpoint inhibitors, such as pembrolizumab, have significantly improved cancer patient outcome. Toxicities are usually moderate and manageable. However, some adverse events, if not early recognised, could be life-threatening. We report a patient with non-small cell lung cancer who received treatment with pembrolizumab and developed multiple immune-related adverse events both during and after completing treatment, including rash, pericarditis, colitis and myasthenia gravis.
Lyme carditis presenting as atrial fibrillation in a healthy young male
Authors: Shabbir Muhammad Asim , Saad Shaukat Muhammad Hamza , Arshad Muhammad Hashaam , Sacco Joseph
Published: June 2019

We present a case of a 23-year-old man coming with palpitations, found to be in atrial fibrillation (AF). He was initially managed with metoprolol for rate-controlled therapy—reverted to normal sinus rhythm and discharged home. He returned a few days later—this time in varying degrees of atrioventricular block including transient complete heart block. He was empirically started on intravenous ceftriaxone for suspected Lyme carditis, which subsequently led to the resolution of high-degree heart block. Lyme immunoglobulin G (IgG) and IgM returned positive. Follow-up ECG after the course of antibiotic exhibited normal sinus rhythm. AF is a rare presentation of Lyme disease but still exists. It should be considered in terms of appropriate treatment, especially in Lyme-endemic areas.
Massive angiomyofibroblastoma of the glans penis
Authors: Monib Sherif , Ibrahim Mohamed
Published: June 2019

Male genital tract angiomyofibroblastoma (AMF) is a rare benign tumour, with a total of 34 cases reported in literature. We are presenting a case of AMF of the glans penis in a 68-year-old man who presented with a progressively increasing in size large lesion located on the tip of his penis. Following routine investigations, the lesion was surgically excised with no adjuvant treatment, the patient was followed-up for 5 years with no evidence of local, nodal or distant recurrence. As AMF of the glans penis is extremely rare, there is not enough literature to support management guide lines, but it appears that AMF responds very well to complete surgical excision; occasional cases of recurrence have been previously reported, so a long-term follow-up is advised.
Modulation of cytokine patterns and microbiome during pregnancy in IBD
Authors: van der Giessen Janine , Binyamin Dana , Belogolovski Anna , Frishman Sigal , Tenenbaum-Gavish Kinneret , Hadar Eran , Louzoun Yoram , Peppelenbosch Maikel Petrus , van der Woude Christien Janneke , Koren Omry , Fuhler Gwenny Manel
Published: June 2019

Objective

Pregnancy may affect the disease course of IBD. Both pregnancy and IBD are associated with altered immunology and intestinal microbiology. However, to what extent immunological and microbial profiles are affected by pregnancy in patients with IBD remains unclear.

Design

Faecal and serum samples were collected from 46 IBD patients (31 Crohn’s disease (CD) and 15 UC) and 179 healthy controls during first, second and third trimester of pregnancy, and prepregnancy and postpartum for patients with IBD. Peripheral blood cytokine profiles were determined by ELISA, and microbiome analysis was performed by sequencing the V4 region of the bacterial 16S rRNA gene.

Results

Proinflammatory serum cytokine levels in patients with IBD decrease significantly on conception. Reduced interleukin (IL)-10 and IL-5 levels but increased IL-8 and interferon (IFN)γ levels compared with healthy controls were seen throughout pregnancy, but cytokine patterns remained stable during gestation. Microbial diversity in pregnant patients with IBD was reduced compared with that in healthy women, and significant differences existed between patients with UC and CD in early pregnancy. However, these microbial differences were no longer present during middle and late pregnancy. Dynamic modelling showed considerable interaction between cytokine and microbial composition.

Conclusion

Serum proinflammatory cytokine levels markedly improve on conception in pregnant patients with IBD, and intestinal microbiome diversity of patients with IBD normalises during middle and late pregnancy. We thus conclude that pregnancy is safe and even potentially beneficial for patients with IBD.
Occupational and work-related respiratory disease attributed to cleaning products
Authors: Carder Melanie , Seed Martin J , Money Annemarie , Agius Raymond M , van Tongeren Martie
Published: June 2019

Objectives

Exposure to cleaning products has been associated with adverse respiratory outcomes. This study aimed to investigate the medically reported incidence, trends in incidence and occupational determinants of work-related respiratory disorders attributed to cleaning agents and to explore the role of ‘Quantitative Structure Activity Relationships’ (QSAR) in corroborating the identification of chemical respiratory sensitisers.

Methods

Respiratory diagnoses attributed to cleaning agents were extracted from The Health and Occupation Research (THOR) surveillance network, 1989–2017. Incidence, trends in incidence and incidence rate ratios by occupation were investigated. Agents were classified by chemical type and QSAR hazard indices were determined for specific organic chemicals.

Results

Approximately 6% (779 cases) of the (non-asbestos) THOR respiratory cases were attributed to cleaning agents. Diagnoses were predominantly asthma (58%) and inhalation accidents (27%) with frequently reported chemical categories being aldehydes (30%) and chlorine/its releasers (26%). No significant trend in asthma incidence (1999–2017) was observed (annual average change of −1.1% (95% CI −4.4 to 2.4)). This contrasted with a statistically significant annual decline in asthma incidence (−6.8% (95% CI −8.0 to −5.6)) for non-cleaning agents. There was a large variation in risk between occupations. 7 of the 15 organic chemicals specifically identified had a QSAR generated hazard index consistent with being a respiratory sensitiser.

Conclusion

Specific occupations appear to be at increased risk of adverse respiratory outcomes attributed to cleaning agents. While exposure to agents such as glutaraldehyde have been addressed, other exposures, such as to chlorine, remain important. Chemical features of the cleaning agents helped distinguish between sensitising and irritant agents.
Controlling Matter at the Molecular Scale with DNA Circuits
Authors: Scalise Dominic , Schulman Rebecca
Published: June 2019

In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical and material systems. This review describes processes that can be sensed and controlled within such a paradigm. Specifically, there are interfaces that can release strands of DNA in response to chemical signals, wavelengths of light, pH, or electrical signals, as well as DNA strands that can direct the self-assembly and dynamic reconfiguration of DNA nanostructures, regulate particle assemblies, control encapsulation, and manipulate materials including DNA crystals, hydrogels, and vesicles. These interfaces have the potential to enable chemical circuits to exert algorithmic control over responsive materials, which may ultimately lead to the development of materials that grow, heal, and interact dynamically with their environments.
Biomaterials: Been There, Done That, and Evolving into the Future
Authors: Ratner Buddy D.
Published: June 2019

Biomaterials as we know them today had their origins in the late 1940s with off-the-shelf commercial polymers and metals. The evolution of materials for medical applications from these simple origins has been rapid and impactful. This review relates some of the early history; addresses concerns after two decades of development in the twenty-first century; and discusses how advanced technologies in both materials science and biology will address concerns, advance materials used at the biointerface, and improve outcomes for patients.
The impact of deep breathing and alternate nostril breathing on heart rate variability: a human physiology laboratory
Authors: Levin Charles J. , Swoap Steven J.
Published: June 2019

An increase in the beat-to-beat variability of heart rate (HRV) is a robust marker of enhanced parasympathetic activity and of a calm and relaxed state. The purpose of this laboratory activity was to introduce the concept of HRV to our students, while having them address a novel question of whether two yogic breathing techniques, namely alternate nostril breathing (ANB) and standard deep breathing (DB), impact the SD of instantaneous heart rate (SDHR), a measure of HRV. Fifty-five undergraduates enrolled in a physiology course designed for nonscience majors were tasked with analyzing HR and SDHR from electrocardiograms recorded during normal breathing, DB, and ANB. A repeated-measures ANOVA showed that HR was significantly, albeit slightly, elevated from normal (74.5 ± 13.4 beats/min; means ± SD) during DB (76.5 ± 11.2 beats/min), but not during ANB (75.7 ± 10.1 beats/min). Analysis of SDHR showed significant differences between conditions (normal: 5.5 ± 2.1, DB: 8.6 ± 3.0, ANB: 7.8 ± 2.8 beats/min). The instructors further analyzed the same data set using more robust measures of HRV (SD of sequential N-N intervals, root mean square of successive differences, and high-frequency domain of HRV) to determine whether SDHR during a 2-min epoch is a sufficient measure for HRV in the undergraduate course setting. Statistical analysis for these measures showed a near identical pattern of magnitude and significance among the groups as SDHR. Our students developed a greater appreciation for the effects of breathing patterns on HRV and HR, using the simple measure of SDHR.
Impact of a playful booklet about diabetes and obesity on high school students in Campinas, Brazil
Authors: Soares Gabriela M. , Zangerolamo Lucas , Rosa Lucas R. O. , Branco Renato C. S. , Carneiro Everardo M. , Barbosa-Sampaio Helena C.
Published: June 2019

Obesity and diabetes are two of the biggest public health problems in the modern world. One possible way to combat the rising prevalence of these diseases is through the spread of awareness about its consequences and how to prevent them. Therefore, educational interventions focused on teaching the physiological basis of these conditions might be valuable tools. However, most scholar curriculums lack high-quality material devoted to this topic. Thus we developed an educational booklet, composed of playful elements, targeted toward high school students and destined for application in classrooms. The efficacy of the developed material was validated through a pretest-posttest design, in which the students had to answer a 10-question test. After booklet completion, students had better outcomes, with an increase in the percentage of correct answers in 7 out of 10 questions contained in the test ( P < 0.05). Thus we developed an effective material for usage in the high school classroom to spread the awareness of the risks of metabolic diseases and how to prevent them.
Developing and Testing Electronic Health Record-Derived Caries Indices
Authors: White Joel M. , Mertz Elizabeth A. , Mullins Joanna M. , Even Joshua B. , Guy Trey , Blaga Elena , Kottek Aubri M. , Kumar Shwetha V. , Bangar Suhasini , Vaderhobli Ram , Brandon Ryan , Santo William , Jenson Larry , Gansky Stuart A.
Published: June 2019

Caries indices, the basis of epidemiologic caries measures, are not easily obtained in clinical settings. This study’s objective was to design, test, and validate an automated program (Valid Electronic Health Record Dental Caries Indices Calculator Tool [VERDICT]) to calculate caries indices from an electronic health record (EHR). Synthetic use case scenarios and actual patient cases of primary, mixed, and permanent dentition, including decayed, missing, and filled teeth (DMFT/dmft) and tooth surfaces (DMFS/dmfs) were entered into the EHR. VERDICT measures were compared to a previously validated clinical electronic data capture (EDC) system and statistical program to calculate caries indices. Four university clinician-researchers abstracted EHR caries exam data for 45 synthetic use cases into the EDC and post-processed with SAS software creating a gold standard to compare the ­VERDICT-derived caries indices. Then, 2 senior researchers abstracted EHR caries exam data and calculated caries indices for 24 patients, allowing further comparisons to VERDICT indices. Agreement statistics were computed among abstractors, and discrepancies were resolved by consensus. Agreement statistics between the 2 final-phase abstractors and the VERDICT measures showed extremely high concordance: Lin’s concordance coefficients (LCCs) >0.99 for dmfs, dmft, DS, ds, DT, dt, ms, mt, FS, fs, FT, and ft; LCCs >0.95 for DMFS and DMFT; and LCCs of 0.92–0.93 for MS and MT. Caries indices, essential to developing primary health outcome measures for research, can be reliably derived from an EHR using VERDICT. Using these indices will enable population oral health management approaches and inform quality improvement efforts.
Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid
Authors: Kopsidas Konstantinos , Ford Rebecca , Ahmed Ibrar , Coupland Sarah E.
Published: June 2019

Background/Aims: We present a case of 2 concomitant tumours, i.e., a sebaceous carcinoma (SC) and a small lymphocytic lymphoma (SLL), in the lacrimal gland of a patient with Muir-Torre syndrome. Methods: Clinical history, orbital examination, diagnostic biopsy, excisional biopsy, and histopathologic analysis were utilized. Results: An 89-year-old female presented to the eye casualty with corneal ulcer, anterior uveitis, proptosis, and restricted ocular motility. She has a clinical history of breast cancer, colon carcinoma, and SC of the eyelid, which had been resected completely 2 years before. Clinical examination, imaging, and diagnostic biopsy confirmed orbital SC recurrence. Exenteration and subsequent histopathologic analysis of the specimen revealed lymphocytic infiltrates consistent with SLL within the lacrimal gland. Conclusion: We report for the first time a case of a patient with Muir-Torre syndrome who developed an orbital recurrent SC with an incidental finding of a lacrimal gland B non-Hodgkin lymphoma consistent with SLL. Clinicians should be aware of the possibility of this coexistence of multiple cancer types in patients with sebaceous carcinoma and Muir-Torre syndrome.
Papillon-Lefèvre Syndrome and Basal Cell Carcinoma: A Case Study
Authors: Alsaif Fahad M. , Arafah Maria A. , Alenazi Rasha T. , Alotaibi Ghadah F.
Published: June 2019

Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar keratoderma and early-onset periodontitis. It was first described by Papillon and Lefèvre in 1924. PLS is caused by mutations in the cathepsin-C (CTSC) gene. The development of malignant skin neoplasms in PLS patients is extremely rare. To date, there have been two cases of malignant melanoma (MM) in PLS patients reported in international journals. Further, only one case of squamous cell carcinoma (SCC) has been reported in PLS patients. To the best of our knowledge, no cases with basal cell carcinoma in PLS patients have been reported in literature. Thus, we report a case of a 55-year-old male from Arabic Saudi with PLS and basal cell carcinoma. The patient was homozygous for a G-to-C substitution at the nucleotide position 815 (CTSC, c.815G>Cp.(Arg272Pro), which is a pathogenic variant. Since this is not the first case of skin cancer in PLS patients, we are supporting the possibility that cathepsin-C play a role in cancer development.
Negativation of PD-L1 Postoperatively in Initially Inoperable Stage III Non-Small Cell Lung Cancer Treated with Pembrolizumab: Two Case Reports
Authors: Nasr Fadi , Al Ghoche Ahmad , Eid Roland , Nasr Lewis , Diab Saada , Hallit Souheil , Riachi Moussa
Published: June 2019

Stage III non-small cell lung cancer is a border line stage between localized and metastatic disease. PDL-1 is gaining an important role in the therapeutic arsenal of lung cancer, the most frequent cancer worldwide. We report for the first time a negativation of PDL-1 status in 2 cases of stage IIIA NSCLC with conversion to operable disease after using immunotherapy. The first patient was a 59-year old female diagnosed incidentally to have stage IIIA inoperable NSCLC that was treated with combination chemo-immunotherapy, and converted to operable disease with a negative PD-L1 in the postoperative setting. The second case is that of a 56-year old male that also had an inoperable stage IIIA NSCLC treated with chemotherapy first line followed by pembrolizumab at progression, then operated after surgical conversion, with negative PD-L1 postoperatively. In front of these findings, further work should be done to elucidate if the reverse of the PDL-1 status and the conversion to operability were due to the use of immunotherapy or to an incidental finding. If confirmed, it may have a therapeutic impact.
BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report
Authors: Moisset Laure , Raimbourg Judith , Hiret Sandrine , Dauve Jonathan , Boisdron-Celle Michèle , Senellart Hélène , Raoul Jean-Luc
Published: June 2019

We report the case of a 32-year-old man with a caecal adenocarcinoma with major lymph node extension and peritoneal carcinomatosis, presenting a BRAF-K601E mutation. A triplet (5FU plus oxaliplatin plus irinotecan) combination with bevacizumab achieved tumor control but the disease progressed immediately after cessation and the patient died 8 months after the diagnosis. A short review of BRAF non-V600E mutations shows that outcome and clinical features depend on the mutation.
O espelho e a máscara: o enigma da comunicação e o caminho do meio
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes, Marcondes Filho Ciro
Published: June 2019

As novas tecnologias de comunicação – televisão digital, internet, telefonia móvel – anunciam oportunidades excepcionais de melhorar a comunicação humana. As pessoas se tornarão mais próximas, a solidão poderá ser efetivamente eliminada. Mas, será que é isso mesmo? Afinal, de qual comunicação falam esses novos equipamentos sociais? Esta obra antecede a trilogia Nova Teoria da Comunicação, em seus 7 volumes, entre 2004 e 2013, cuja intenção foi a de vasculhar esse imenso continente muito comentado, mas desconhecido, dos entrosamentos humanos. Este volume é básico e introdutório. Publicado originalmente em 2002, trata, de forma genérica, das principais correntes da filosofia da linguagem, da psicanálise da comunicação, das linguagens do corpo, discutindo também sobre as tecnologias e a relação com o homem, trazendo, por fim, uma síntese das principais escolas teóricas da comunicação.
Homem & mulher: uma comunicação impossível?
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes, Marcondes Filho Ciro
Published: June 2019

O livro discute as possibilidades e as impossibilidades da comunicação verdadeira e as relações de gênero entre homem e mulher, suas igualdades, diferenças e complementaridades; verdade e castração; o Cristianismo, a mulher e a questão do feminino, da posse; a relação entre economia e felicidade dos casais; a questão do olhar; a sexualidade e a incomunicabilidade dos sexos, a coreografia do desejo e a diferença insuperável; felicidade e amor, falicismo e feminilidade; a questão das chances de uma comunicação dos gêneros - tudo isso é posto em pauta pelo autor, com a inserção dos pensamentos, sobre os temas apresentados, de grandes filósofos como Simone de Beauvoir, Jacques Derrida e Friedrich Nietzsche.
Das coisas que nos fazem pensar, que nos forçam a pensar: o debate sobre a nova teoria da comunicação
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes, Marcondes Filho Ciro
Published: June 2019

Na primeira década do milênio, o Núcleo de Estudos Filosóficos da Comunicação (FiloCom), da Universidade de São Paulo, concluiu sua Nova Teoria da Comunicação que se dedicou à construção de um conceito de comunicação aplicável a todos os fenômenos comunicacionais (TV, imprensa, rádio; cinema, teatro, artes, dança; ou os utilizados na internet), assim como à constituição de um novo procedimento de pesquisa, o metáporo, que buscava se distanciar da rigidez dos métodos até então utilizados, propondo ao pesquisador imergir no processo para melhor poder senti-lo e transmiti-lo àqueles que consultassem seu trabalho. A divulgação e o debate dessa nova proposta foram realizados na Escola de Comunicações e Artes da USP, em fins de 2010, em evento nacional que contou com a colaboração dos mais importantes representantes nacionais dos estudos, reflexões e pesquisas sobre a comunicação.
Padrões discursivos sobre corrupção
Authors: Medeiros Cintia Rodrigues de Oliveira , Freitas Júnior Luiz Romeu de
Published: June 2019

A subjetividade e a percepção que levam à interpretação de atos de corrupção são pouco considerados nos estudos nacionais sobre o fenômeno. O objetivo desta pesquisa é explorar as interpretações de gestores públicos federais e estaduais sobre ‘corrupção’ para identificar possíveis de padrões regionais. Foram realizadas vinte entrevistas com gestores atuantes na gestão federal e estadual de Saúde e Educação no estado de Minas Gerais, lotados no município de Uberlândia. A partir de análise de conteúdo, foram levantados três padrões distintos na fala dos gestores públicos entrevistados: o coronelismo/mandonismo, o patrimonialismo, e o clientelismo. As evidências encontradas nas falas dos entrevistados indicam que potencialmente a formação cultural da região de Uberlândia pode contribuir para a perpetuação da corrupção.
O Value Relevance é relevante?
Authors: Santos Simone Miranda dos , Lemes Sirlei , Barboza Flávio Luiz de Moraes
Published: June 2019

A adoção das IFRS pelas companhias de capital aberto no Brasil trouxe a discussão se as referidas normas melhoraram a qualidade das informações contábeis com efeito destas no preço das ações. Os estudos empíricos atualmente demandam uma nova análise dos resultados encontrados sobre o value relevance do lucro líquido (LL) e do Patrimônio Líquido (PL). Foi realizada uma meta-análise dos estudos publicados sobre o tema, examinando separadamente os modelos de preço e retorno propostos por Ohlson (1995). A amostra constituiu-se de 26 artigos, que analisaram empresas brasileiras no período de 1997 a 2014, totalizando 18.562 observações consideradas pelos artigos que testaram o período pré IFRS e 17.381 observações utilizadas nos testes pós IFRS, para os modelos de preço e retorno. Os resultados indicaram queda do value relevance do PL e ganho na relevância da informação do LL após a adoção das IFRS.
Minettes do Stock Monzonítico Glória Norte: evidência de magmatismo ultrapotássico pós-orogênico, com assinatura de subducção, no Sistema Orogênico Sergipano
Authors: Fontes Milena Prado , Conceição Herbet , Rosa Maria de Lourdes Da Silva , Lisboa Vinicius Anselmo Carvalho
Published: June 2019

Lamprófiros ocorrem como enclaves microgranulares no Stock Monzonítico Glória Norte (SGN) (588 ± 5 Ma), localizado na parte central do Domínio Macururé, do Sistema Orogênico Sergipano, no estado de Sergipe. Esses enclaves lamprofíricos foram classificados como minettes e ocorrem concentrados em uma área com aproximadamente 1 km de diâmetro na região sudeste do stock. Os minettes apresentam texturas porfirítica e panidiomórfica, com fenocristais de biotita e matriz com granulação fina. Os minerais máficos presentes, além da biotita, são: diopsídio, augita, hornblenda e titanita. Ortoclásio pertítico, andesina, biotita, carbonato, apatita e zircão também estão presentes na matriz. Os dados dos elementos maiores (K2O/Na2O > 3, 6 > %MgO > 8, K2O > 3%), menores e traços (baixos valores de Ti, Nb, Ta) indicam magmatismo ultrapotássico orogênico. As razões Th/Yb > 9,00 e 0,05 < Ta/Yb < 0,20 apontam para magma formado por fusão de um manto enriquecido. As informações obtidas neste estudo indicam que magmas básicos ultrapotássicos estiveram presentes durante o período pós-tectônico no Sistema Orogênico Sergipano (SOS).
Development and Initial Validation of the PROMIS®-Plus-HF Profile Measure
Authors: Ahmad Faraz S. , Kallen Michael A. , Schifferdecker Karen E. , Carluzzo Kathleen L. , Yount Susan E. , Gelow Jill M. , McCullough Peter A. , Kimmel Stephen E. , Fisher Elliot S. , Cella David
Published: June 2019

Background:

Bringing together generic and heart failure (HF)–specific items in a publicly available, patient-reported outcome measure may facilitate routine health status assessment for improving clinical care and shared decision-making, assessing quality of care, evaluating new interventions, and comparing groups with different conditions.

Methods and Results:

We performed a mixed-methods study to develop and validate the PROMIS®-Plus-HF (Patient-Reported Outcomes Measurement Information System®-Plus-Heart Failure) profile measure—a HF-specific instrument based on the generic PROMIS. We conducted 8 focus groups with 61 patients with HF and phone interviews with 10 HF clinicians. The measure was developed via an iterative process of reviewing existing PROMIS items and developing and testing new HF items. In a 600-patient sample, we estimated reliability (internal consistency; test-retest, with n=100 participants). We conducted validity analyses using Pearson
r
and Spearman ρ correlations with Kansas City Cardiomyopathy Questionnaire subscores. In a longitudinal sample, we performed responsiveness testing (paired
t
tests) with 75 patients with HF receiving interventions with expected health status improvement. The PROMIS-Plus-HF measure comprises 86 items (64 existing; 22 new) across 18 domains. Internal consistency reliability (Cronbach α) coefficients ranged from 0.52 to 0.96, with α≥0.70 in 12 of 17 domains. Test-retest intraclass correlation coefficients were ≥0.90. Correlations with Kansas City Cardiomyopathy Questionnaire subscores supported expected convergent (
r
/ρ>0.60) and divergent validity (
r
/ρ<0.30). In the longitudinal sample, 10 of 18 domains had improved (
P
<0.05) scores from baseline to follow-up.

Conclusions:

The PROMIS-Plus-HF profile measure—a complete assessment of physical, mental, and social health—exhibited good psychometric characteristics and may facilitate patient-centered care and research. Subsets of domains and items can be used depending on the clinical or research purpose.
Clinic-Based Strategies to Reach United States Million Hearts 2022 Blood Pressure Control Goals
Authors: Bellows Brandon K. , Ruiz-Negrón Natalia , Bibbins-Domingo Kirsten , King Jordan B. , Pletcher Mark J. , Moran Andrew E. , Fontil Valy
Published: June 2019

Background:

The Centers for Disease Control and Prevention’s Million Hearts initiative includes an ambitious ≥80% blood pressure control goal in US adults with hypertension by 2022. We used the validated Blood Pressure Control Model to quantify changes in clinic-based hypertension management processes needed to attain ≥80% blood pressure control.

Methods and Results:

The Blood Pressure Control Model simulates patient blood pressures weekly using 3 key modifiable hypertension management processes: office visit frequency, clinician treatment intensification given uncontrolled blood pressure, and continued antihypertensive medication use (medication adherence rate). We compared blood pressure control rates (using the Seventh Joint National Committee on hypertension targets) achieved over 4 years between usual care and the best-observed values for management processes identified from the literature (1-week return visit interval, 20%–44% intensification rate, and 76% adherence rate). We determined the management process values needed to achieve ≥80% blood pressure control in US adults. In adults with uncontrolled blood pressure, usual care achieved 45.6% control (95% uncertainty interval, 39.6%–52.5%) and literature-based best-observed values achieved 79.7% control (95% uncertainty interval, 79.3%–80.1%) over 4 years. Increasing treatment intensification rates to 62% of office visits with an uncontrolled blood pressure resulted in ≥80% blood pressure control, even when the return visit interval and adherence remained at usual care values. Improving to best-observed values for all 3 management processes would achieve 78.1% blood pressure control in the overall US population with hypertension, approaching the ≥80% Million Hearts 2022 goal.

Conclusions:

Achieving the Million Hearts blood pressure control goal by 2022 will require simultaneously increasing visit frequency, overcoming therapeutic inertia, and improving patient medication adherence. As the relative importance of each of these 3 processes will depend on local characteristics, simulation models like the Blood Pressure Control Model can help local healthcare systems tailor strategies to reach local and national benchmarks.
Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in
RAF1
-Associated Noonan Syndrome
Authors: Jaffré Fabrice , Miller Clint L. , Schänzer Anne , Evans Todd , Roberts Amy E. , Hahn Andreas , Kontaridis Maria I.
Published: June 2019

Background:

More than 90% of individuals with Noonan syndrome (NS) with mutations clustered in the CR2 domain of
RAF1
present with severe and often lethal hypertrophic cardiomyopathy (HCM). The signaling pathways by which NS
RAF1
mutations promote HCM remain elusive, and so far, there is no known treatment for NS-associated HCM.

Methods:

We used patient-derived

RAF1
S257L/+

and CRISPR-Cas9–generated isogenic control inducible pluripotent stem cell (iPSC)–derived cardiomyocytes to model NS
RAF1
-associated HCM and to further delineate the molecular mechanisms underlying the disease.

Results:

We show that mutant iPSC–derived cardiomyocytes phenocopy the pathology seen in hearts of patients with NS by exhibiting hypertrophy and structural defects. Through pharmacological and genetic targeting, we identify 2 perturbed concomitant pathways that, together, mediate HCM in
RAF1
mutant iPSC–derived cardiomyocytes. Hyperactivation of mitogen-activated protein kinase kinase 1/2 (MEK1/2), but not extracellular regulated kinase 1/2, causes myofibrillar disarray, whereas the enlarged cardiomyocyte phenotype is a direct consequence of increased extracellular regulated kinase 5 (ERK5) signaling, a pathway not previously known to be involved in NS. RNA-sequencing reveals genes with abnormal expression in
RAF1
mutant iPSC–derived cardiomyocytes and identifies subsets of genes dysregulated by aberrant MEK1/2 or ERK5 pathways that could contribute to the NS-associated HCM.

Conclusions:

Taken together, the results of our study identify the molecular mechanisms by which NS
RAF1
mutations cause HCM and reveal downstream effectors that could serve as therapeutic targets for treatment of NS and perhaps other, more common, congenital HCM disorders.
HHIPL1
, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis
Authors: Aravani Dimitra , Morris Gavin E. , Jones Peter D. , Tattersall Helena K. , Karamanavi Elisavet , Kaiser Michael A. , Kostogrys Renata B. , Ghaderi Najafabadi Maryam , Andrews Sarah L. , Nath Mintu , Ye Shu , Stringer Emma J. , Samani Nilesh J. , Webb Tom R.
Published: June 2019

Background:

Genome-wide association studies have identified chromosome 14q32 as a locus for coronary artery disease. The disease-associated variants fall in a hitherto uncharacterized gene called
HHIPL1
(
hedgehog interacting protein
-
like 1
), which encodes a sequence homolog of an antagonist of hedgehog signaling. The function of HHIPL1 and its role in atherosclerosis are unknown.

Methods:

HHIPL1 cellular localization, interaction with sonic hedgehog (SHH), and influence on hedgehog signaling were tested.
HHIPL1
expression was measured in coronary artery disease–relevant human cells, and protein localization was assessed in wild-type and
Apoe
−/−
(apolipoprotein E deficient) mice. Human aortic smooth muscle cell phenotypes and hedgehog signaling were investigated after gene knockdown.
Hhipl1
−/−
mice were generated and aortic smooth muscle cells collected for phenotypic analysis and assessment of hedgehog signaling activity.
Hhipl1
−/−
mice were bred onto both the
Apoe
−/−
and
Ldlr
−/−
(low-density lipoprotein receptor deficient) knockout strains, and the extent of atherosclerosis was quantified after 12 weeks of high-fat diet. Cellular composition and collagen content of aortic plaques were assessed by immunohistochemistry.

Results:

In vitro analyses revealed that HHIPL1 is a secreted protein that interacts with SHH and increases hedgehog signaling activity.
HHIPL1
expression was detected in human smooth muscle cells and in smooth muscle within atherosclerotic plaques of
Apoe
−/−
mice. The expression of
Hhipl1
increased with disease progression in aortic roots of
Apoe
−/−
mice. Proliferation and migration were reduced in
Hhipl1
knockout mouse and
HHIPL1
knockdown aortic smooth muscle cells, and hedgehog signaling was decreased in
HHIPL1
-deficient cells.
Hhipl1
knockout caused a reduction of >50% in atherosclerosis burden on both
Apoe
−/−
and
Ldlr
−/−
knockout backgrounds, and lesions were characterized by reduced smooth muscle cell content.

Conclusions:

HHIPL1 is a secreted proatherogenic protein that enhances hedgehog signaling and regulates smooth muscle cell proliferation and migration. Inhibition of HHIPL1 protein function might offer a novel therapeutic strategy for coronary artery disease.
Comparison of Cardiovascular Health Between US Army and Civilians
Authors: Shrestha Alice , Ho Tiffany E. , Vie Loryana L. , Labarthe Darwin R. , Scheier Lawrence M. , Lester Paul B. , Seligman Martin E. P.
Published: June 2019

Background

Cardiovascular conditions are common in US Army and civilian populations. The recently developed concept of ideal cardiovascular health provides a new approach to evaluating population cardiovascular status.

Methods and Results

We defined a cohort of 263 430 active duty Army personnel, aged 17 to 64 years, who completed a 2012 physical examination and a corresponding subset of the noninstitutionalized, civilian US population, who participated in the National Health and Nutrition Examination Survey (
NHANES
) 2011 to 2012 cycle. We compared 4 cardiovascular health metrics (current smoking, body mass index, blood pressure, and diabetic status) between Army and civilian groups overall, and separately by sex, race/ethnicity, and age. The Army population was younger, was less often women or Hispanic, and had less post–high school education than the
NHANES
population. Smoking rates were ≈20% in the Army and
NHANES
groups, but <15% among Army women and Hispanics. Overall, one third of the Army and
NHANES
groups and
NHANES
women, but nearly half of Army women, demonstrated ideal body mass index. Ideal blood pressure was strikingly less prevalent in the Army than
NHANES
participants (30% versus 55%). Diabetes mellitus was rare in both groups.

Conclusions

Ideal cardiovascular health was less prevalent in the Army than NHANES group, despite exclusion of the least healthy recruits. Prevalence of ideal body mass index and blood pressure was low in both the Army and NHANES groups, even at early adult ages. This finding reveals the need for policy changes to promote, preserve, and improve ideal cardiovascular health in both the Army and the US population as a whole.
Preterm Birth is Associated With Increased Blood Pressure in Young Adult Women
Authors: Skudder‐Hill Loren , Ahlsson Fredrik , Lundgren Maria , Cutfield Wayne S. , Derraik José G. B.
Published: June 2019

Background

While there is some evidence of elevated blood pressure later in life in preterm survivors, data on adult women are still lacking. Thus, we assessed the associations between preterm birth and blood pressure in young adult women.

Methods and Results

We studied 5232 young adult women who volunteered for military service in Sweden between 1990 and 2007. Anthropometric and clinic blood pressure data were collected during the medical examination at the time of conscription. There was a progressive decline in systolic and diastolic blood pressures, as well as in mean arterial pressure, with increasing gestational age. Women born preterm had an adjusted increase in systolic blood pressure of 3.8 mm Hg (95%
CI
, 2.5–5.1;
P
<0.0001) and mean arterial pressure of 1.9 mm Hg (95%
CI
, 0.9–2.8;
P
=0.0001) compared with young women born at term. Rates of systolic hypertension were also considerably higher in young women born preterm (14.0% versus 8.1%,
P
<0.0001), as were rates of isolated systolic hypertension. The adjusted relative risk of systolic hypertension in women born preterm was 1.72 (95%
CI
, 1.26–2.34;
P
<0.001) that of women born at term or post‐term, but there was no significant difference in the risk of diastolic hypertension (adjusted relative risk, 1.60; 95%
CI
, 0.49–5.20).

Conclusions

Young adult women born preterm display elevated systolic blood pressure and an increased risk of hypertension compared with peers born at term or post‐term.
Profiling Hospital Performance on the Basis of Readmission After Transcatheter Aortic Valve Replacement in Ontario, Canada
Authors: Elbaz‐Greener Gabby , Qiu Feng , Webb John G. , Henning Kayley A. , Ko Dennis T. , Czarnecki Andrew , Roifman Idan , Austin Peter C. , Wijeysundera Harindra C.
Published: June 2019

Background

Readmission rates are a widely accepted quality indicator. Our objective was to develop models for calculating case‐mixed adjusted readmission rates after transcatheter aortic valve replacement for the purpose of profiling hospitals.

Methods and Results

In this population‐based study in Ontario, Canada, we identified all transcatheter aortic valve replacement procedures between April 1, 2012, and March 31, 2016. For each hospital, we first calculated 30‐day and 1‐year risk‐standardized (predicted versus expected) readmission rates, using 2‐level hierarchical logistic regression models, including clustering of patients within hospitals. We also calculated the risk‐adjusted (observed versus expected) readmission rates, accounting for the competing risk of death using a Fine‐Gray competing risk model. We categorized hospitals into 3 groups: those performing worse than expected, those performing better than expected, or those performing as expected, on the basis of whether the 95% CI was above, below, or included the provincial average readmission rate respectively. Our cohort consisted of 2129 transcatheter aortic valve replacement procedures performed at 10 hospitals. The observed readmission rate was 15.4% at 30 days and 44.2% at 1 year, with a range of 10.9% to 21.7% and 38.8% to 55.0%, respectively, across hospitals. Incorporating the competing risk of death translated into meaningful different results between models; as such, we concluded that the risk‐adjusted readmission rate was the preferred metric. On the basis of the 30‐day risk‐adjusted readmission rate, all hospitals performed as expected, with a 95%
CI
that included the provincial average. However, we found that there was significant variation in 1‐year risk‐adjusted readmission rate.

Conclusions

There is significant interhospital variation in 1‐year adjusted readmission rates among hospitals, suggesting that this should be a focus for quality improvement efforts in transcatheter aortic valve replacement.
Preterm Birth Is Associated With Increased Blood Pressure in Young Adults: Important Opportunities for Blood Pressure Management
Authors: Jones Daniel W. , Clark Donald , Hall Michael E.
Published: June 2019

See Article
Skudder‐Hill et al
Composing Vocal Distortion: A Tool for Real-Time Generation of Roughness
Authors: Gentilucci Marta , Ardaillon Luc , Liuni Marco
Published: June 2019

This article presents the results of collaboration between a composer and researchers in the context of vocal roughness and composing for voice. Our research focused on parametric control of distortion. Specifically, we present a software device that supports the manipulation and control of vocal roughness in real time, using a method based on amplitude modulation and filtering. The compositional interest in working with classically trained opera singers and with vocal distortion led us to initiate research in the signal-processing domain. Our goal was to develop a tool that could facilitate the production of distorted sounds without direct effort on the part of the singer. In this way, the singer can perform a nondistorted or lightly distorted sound, and the software tool will generate or magnify the distortion in real time.