bluuebunny/crossref_metadata_2025 huggingface dataset:
Motion Graphic Dalam Perancangan Media Promosi Produk Suplemen Di Starsfits
Authors: Simbolon Agnes Christin Evyanti , Suandi Fadli
Published: July 2022

suplemen fitness yang dimana membutuhkan media promosi karena banyak masyarakat kurang mengetahui mengenai Starsfits. Sehingga dibuatlah motion graphic sebagai media promosi yang merupakan salah satu bentuk media informasi terhadap perkembangan teknologi. Perancangan video motion graphic ini bertujuan untuk mengenalkan tentang produk suplemen di Starsfits yang diharapkan mampu menarik minat konsumen sebagai upaya untuk meningkatkan penjualan produk suplemen di Starsfits. Motion graphic pada video promosi produk suplemen di Starsfits dibuat menggunakan metode perancangan multimedia versi Villamil-Molina yang terdiri dari tahapan development, preproduction, production, postproduction, dan delivery. Berdasarkan hasil analisis video motion graphic telah memenuhi indikator kalayakan penerapan aspek-aspek motion graphic yaitu Spatial, Temporal, Live Action dan Typography yang didapatkan hasil 4,36 yang termasuk kedalam kategori (SL) sangat layak. Kemudian dilakukan analisis EPIC model untuk mengetahui pengaruh dan efektifitas video promosi produk suplemen di Starsfits. Kesimpulan hasil analisis EPIC model adalah: (1) dimensi Empathy 4,88, (2) Persuation 4,76, (3) Impact 4,85, (4) Communication 4,87, dengan begitu motion graphic pada video promosi produk suplemen di Starsfits dinyatakan sangat efektif sebagai media promosi.
Mengatasi Data Error Pada Proses Data Cleaning Motion Capture Motive Optitrack
Authors: Zega Selly Artaty , Saropi Ahmad , Ronaldy Timothy , Ilhami Yogi , Farabi Muhammad
Published: July 2022

Motion capture adalah sebuah teknologi dalam industri multimedia yang berguna untuk merekam gerakan secara digital dengan menggunakan metode sensor.Teknologi motion capture semakin berkembang dari waktu ke waktu, motion capture sudah digunakan di beberapa produk digital seperti game, efek visual, dan film animasi.pada proses perekaman gerakan, motion capture menggunakan sensor optik atau sensor magnet, langkah selanjutnya adalah proses pembersihan data.proses pembersihan data akan membersihkan noise atau kesalahan gerakan. Menggunakan motion capture akan membuat proses produksi lebih cepat karena motion capture tidak menggunakan cara manual keyframe.Artikel ini bertujuan untuk membantu pengguna aplikasi motive agar proses pembersihan data menjadi lebih cepat dengan metode penelitian dan pengembangan. Dengan data-data yang telah terkumpul dalam beberapa proses perekaman, penulis berharap artikel ini dapat digunakan sebagai panduan dalam merekam gerak hingga proses pembersihan data dengan aplikasi motif.
Alat Sterilisasi Lampu UVC Portable Berbasis IOT
Authors: Fitriyah Qoriatul , Siahaan Yeni Delfiana , Wahyudi Muhammad Prihadi Eko
Published: July 2022

Penelitian ini dilakukan untuk meningkatkan keandalan penyinaran Lampu UVC dalam membunuh virus. Sejak pertama diketahui pada bulan November 2019 pandemi covid-19 telah menyebar sampai di sekitar kita dan memakan banyak korban jiwa. Bermacam pencegahan sudah dilakukan oleh pemerintah dan juga individu. Salah satu pencegahan yang dapat dilakukan adalah melakukan sterilisasi ruangan atau permukaan benda dengan menggunakan sinar UV. Untuk membunuh virus dapat   digunakan sinar ultraviolet (UV) tipe C. Dengan dosis 220J/m² menghasilkan pengurangan virus SARS-CoV-2 atau covid 19 di udara atau suatu permukaan. Permasalahan yang muncul adalah, lampu UVC yang digunakan hanya sebatas on-off dengan durasi yang tidak menentu. Alat ini nantinya diharapkan mampu melakukan perhitungan secara otomatis untuk menentukan durasi nyala penyinaran hanya dengan memasukkan informasi luas ruangan. Untuk keselamatan pengguna saat pemakaian sinar UVC, alat ini juga akan dilengkapi dengan kendali jarak jauh dan sensor keberadaan.
Metode Peningkatan Akurasi pada Sensor TDS Berbasis Arduino untuk Nutrisi Air Menggunakan Regresi Linier
Authors: Tisna Dhodit Rengga , Martin Putra Berlian Juliartha , Maharani Tamara , Hasnira Hasnira
Published: July 2022

Kualitas air memegang peranan penting dalam bidang budidaya perikanan. Faktor yang menentukan kualitas air salah satunya adalah kadar TDS (Total Disolved Solid). Oleh karena itu dibutuhkan TDS meter yang memiliki akurasi yang presisi agar mampu mengukur kualitas berbagai jenis air secara akurat. Dalam penelitian ini mengembangkan protype yang mampu mengukur kadar TDS dalam air. Prototype ini terdiri atas perangkat sensor TDS, Arduino UNO dan LCD untuk menampilkan hasil pembacaan kualitas air yang diukur. Supaya akurasi yang dibaca prototype mampu mengimbangi TDS meter komersil, maka peneliti menggunakan algoritma regresi linier untuk dimasukkan ke dalam program program TDS Arduino. Hasil dari eksperimen menunjukkan akurasi prototype TDS yang semula 77% naik menjadi 98.3% hampir mendekati presisi dengan TDS meter komersil pada umumunya.
Study of Lead-Free Solder Joint Reliability
Authors: Maulidiah Hana Mutialif , Budiana Budiana , Puspita Widya Rika , Jefiza Adlian , Mustanir Mustanir
Published: July 2022

Solders are essential for the construction of many engineering materials. The use of soldering in electronic packaging has become increasingly critical in today's world. In the electronic manufacturing industry, alternative soldering materials based on tin metal have developed gradually over the last two decades. Manufacturing companies are primarily concerned about removing lead from electronic manufacturing and waste recycling by switching to the lead-free solder. Environmental and human health are adversely affected by exposure to high lead levels in consumer products. The manufacturing industry has switched to lead-free soldering to support their social responsibility initiatives. The three categories of lead-free solder are classified according to temperature range: high-temperature solder, medium-temperature solder, and low-temperature solder. This research is conducted based on the approach of study literature, which is obtained from some papers that generally explain lead-free solder. To provide additional knowledge which is expected to add new insights about the importance of lead-free usage and its behavior.
Rancang Bangun Sistem Pengelolaan Barang Milik Negara Berbasis QR Code
Authors: THohari Ahmad Hamim , Hidayat Febrianto , Fani Maidel , Nelmiawati Nelmiawati
Published: July 2022

Barang Milik Negara (BMN) adalah semua aset yang dibeli atau diperoleh atas beban Anggaran Pendapatan dan Belanja Negara (APBN) maupun perolehan lain yang sah. Politeknik Negeri Batam sebagai entitas pemerintah dituntut untuk mengelola, menggunakan dan memelihara BMN agar mendapat manfaat dari aset tersebut. Pemanfaatan teknologi mutlak diperlukan dalam pengelolaan tersebut. Sistem pengelolaan saat ini dilakukan dengan mencetak nomor inventaris dan menempelkan pada setiap barang. Sistem ini menyulitkan pelacakan dan pengecekan inventaris pada masa penggunaan dan perawatan. Dari permasalahan tersebut diusulkan sebuah sistem pengelolaan BMN berbasis QRCode yang terdiri dari dua aplikasi yaitu web dan mobile. Aplikasi dikembangkan dengan metode prototyping yang bersifat iteratif untuk mendapat kecepatan dan ketepatan sesuai kebutuhan pengguna. Aplikasi mobile berfungsi mengakses data barang secara cepat dengan memindai kode barang, aplikasi web dengan QR Code generator untuk mengelola data barang serta membuat QR Code berdasarkan kode barang. Aplikasi mobile dikembangkan menggunakan Ionic Framework, sedangkan aplikasi web dibangun dengan AngularJS. Hasil pengujian aplikasi menunjukkan bahwa seluruh fungsional yang telah didefinisikan dapat berfungsi dan memenuhi kebutuhan pengguna.
Analysis of Amateur Runners’ Fluid Loss in Relation to their Invested Energy
Authors: F Gabor
Published: July 2022

Objective: In this analysis, we look for answers as to how the dehydration level of runners’ changes in relation to their invested energy (measured in watts) in an 11.6km flat area as well as while hiking Hungary’s highest hill, Kékes. Sample and methods: 12 persons were included in the study, all of whom completed the so-called 2018 ‘Kékes peak running race’, a challenge over 11.6km with a 670m rise above sea level. Following this event (two weeks later), they ran another 11.6km on Margaret Island in Budapest where the field is completely flat. Results: In the experiment, during the Kékes peak run the runners delivered 333 watts of power. At the end of this race, a 2% body weight loss was observed which corresponds to approximately 1.5l fluid loss. The 12 runners accomplished the same distance in case of the second run too, but on a completely flat field. On average, the runners delivered 300 watts of power while completing the 11.6km long race. After finishing the flat field run, the participants’ weight decreased by 0.5% on average, which constitutes a less than 0.5l fluid loss. The results clearly show that a 10% elevation in power results in almost 4 times more loss of fluids. These results were also supported by the Urine Specific Gravity (USG) test as the USG growth was significant (p < 0.05) during the Kékes peak run.
Effect of Paracervical Block Before Ultrasound Guided High Intensity Focused Ultrasound Treatment in Uterine Fibroids and Adenomyosise
Authors: Lee Jae-Seong , Lee Kye-Hwa , Kim Tae-Eung
Published: July 2022

Background: The purpose of this article was to evaluate the effect of paracervical block before ultrasound-guided high-intensity-focused ultrasound treatment of adenomyosis and uterine fibroids. Methods: This retrospective analysis examined 2173 women who received HIFU treatment for uterine fibroids and adenomyosis, among them 311 patients with paracervical block and 1862 patients without paracervical block, from February 4, 2010 to March 8, 2019. We assessed treatment time, ablation time, treatment energy and volume reduction. Paracervical block (10 cc of 2% lidocaine diluted with epinephrine 1:1 million) was performed before treatment. Results: When paracervical block was performed, the total treatment time was estimated to be 0.886 times (expected (–0.121)) which was statistically significantly shorter (p < 0.0001), ablation time was statistically significantly shorter by 0.853 times (expected (–0.159)) (p < 0.0001), and the total energy was statistically significantly smaller by 0.891 times (expected (–0.115)) (p = 0.0003). There was no significant difference in volume change between the group with and without paracervical block. However, total treatment time, ablation time, and treatment energy were all statistically significantly lower in the group treated with paracervical block. Conclusions: Paracervical block before USgHIFU treatment was a cost-effective method because it helped reduce the total treatment time, ablation time, and total energy.
Identification of Gene-Environment Interactions by Non-Parametric Kendall’s Partial Correlation with Application to TCGA Ultrahigh-Dimensional Survival Genomic Data
Authors: Wang Jie-Huei , Yang Chun-Ting
Published: July 2022

Background: In biomedical and epidemiological studies, gene-environment (G-E) interactions play an important role in the etiology and progression of many complex diseases. In ultra-high-dimensional survival genomic data, two common approaches (marginal and joint models) are proposed to determine important interaction biomarkers. Most existing methods for detecting G-E interactions (marginal Cox model and marginal accelerated failure time model) are limited by a lack of robustness to contamination/outliers in response outcome and prediction biomarkers. In particular, right-censored survival outcomes and ultra-high-dimensional feature space make relevant feature screening even more challenging. Methods: In this paper, we utilize the non-parametric Kendall’s partial correlation method to obtain pure correlation to determine the importance of G-E interactions concerning clinical survival data under a marginal modeling framework. Results: A series of simulated scenarios are conducted to compare the performance of our proposed method (Kendall’s partial correlation) with some commonly used methods (marginal Cox’s model, marginal accelerated failure time model, and censoring quantile partial correlation approach). In real data applications, we utilize Kendall’s partial correlation method to identify G-E interactions related to the clinical survival results of patients with esophageal, pancreatic, and lung carcinomas using The Cancer Genome Atlas clinical survival genetic data, and further establish survival prediction models. Conclusions: Overall, both simulation with medium censoring level and real data studies show that our method performs well and outperforms existing methods in the selection, estimation, and prediction accuracy of main and interacting biomarkers. These applications reveal the advantages of the non-parametric Kendall’s partial correlation approach over alternative semi-parametric marginal modeling methods. We also identified the cancer-related G-E interactions biomarkers and reported the corresponding coefficients with p-values.
Transcriptome Evidence Reveals Mitochondrial Unfolded Protein Response Participate in SH-SY5Y Cells Exposed to Manganese
Authors: Zhang Shixuan , Chen Li , Chen Tian , Zhang Yuanyuan , Ma Junxiang , Ji Hongyun , Guo Caixia , Xiao Zhongxin , Li Jie , Niu Piye
Published: July 2022

Background: Overexposure to manganese (Mn) can lead to neurodegenerative damage, resulting in manganism with similar syndromes to Parkinson’s disease (PD). However, little is known about changes in transcriptomics induced by the toxicological level of Mn. In this study, we conducted RNA-seq to explore the candidate genes and signaling pathways included by Mn in human SH-SY5Y neuroblastoma cells. Methods: The differentially expressed genes (DEGs) between the Mn-treated group and the control group were screened, and weighted gene co-expression network analysis (WGCNA) was employed to identify hub genes. Then, pathway enrichment analyses for those candidate genes were performed in Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). We further validated the concentration- and time-response effects of Mn exposure (0–500 μM, 3–12 h) on mitochondrial unfolded protein response (UPRMT) by real-time quantitative reverse transcription PCR (qRT-PCR). Results: The results showed 179 up-regulated differentially expressed genes (DEGs) and 681 down-regulated DEGs after Mn exposure. Based on the intersection of DEGs genes and hub genes, 73 DEGs were related to neurotoxicity. The comprehensive pathway analysis showed Mn had widespread effects on the mitogen-activated protein kinase (MAPK) signaling pathway, unfolded protein response, longevity regulating pathway, inflammatory bowel disease, and mitophagy signaling pathway. After Mn exposure, the expressions of activating transcription factor 3 (ATF3) and C-C motif chemokine ligand 2 (CCL2) increased, while the expressions of C/EBP homologous protein (CHOP), caseinolytic protease P (CLPP), and Lon protease 1 (LONP1) decreased in a concentration- and time-dependent manner. Conclusions: Overall, our study suggests that UPRMT is a new sight in understanding the mechanism of Mn-induced neurotoxicity.
Diagnostic Modalities in Detecting Cardiovascular Complications of Thalassemia
Authors: Fianza Pandji I. , Pramono Alvinsyah A. , Ghozali Mohammad , Sihite Teddy A. , Setiabudi Djatnika , Syamsunarno Mas R. A. A. , Fucharoen Suthat , Panigoro Ramdan
Published: July 2022

Thalassemia major is the most common monogenetic disorder worldwide, manifested as chronic hemolytic anemia. This condition leads to the need for chronic blood transfusion to be monitored for an iron overload that may be stored in several tissues and organs, including cardiomyocytes, that might cause a broad spectrum of cardiac iron toxicities such as heart failure conduction delays, myocarditis, and arrhythmias. Non-invasive imaging modalities have their benefits and limitations. Each modality complements and generates a comprehensive diagnostic and monitoring of cardiac siderosis in thalassemia major patients.
NLRP3 Inflammasome as a Therapeutic Target for Atherosclerosis: A Focus on Potassium Outflow
Authors: Jin Yi-Jing , An Zhuo-Yu , Sun Zhi-Xuan , Liu Xin-Chen
Published: July 2022

Atherosclerosis is a risk factor for various cardiovascular diseases, and is linked to high rates of morbidity and mortality across the globe. Although numerous complex processes are involved in the development and progression of atherosclerosis, the exact mechanisms behind its pathogenesis remain unclear. Inflammation and endothelial cell damage exert a lasting effect on atherosclerosis, causing lipid and fibrous tissue accumulation in the intima of the artery to form plaques, and subsequently promoting atherosclerosis. Nod-like receptor protein 3 (NLRP3) inflammatory corpuscle is thought to be the link between lipid metabolism and inflammation. Long Potassium outflow is a vital activator of NLRP3, with a simultaneous effect as a start-up and adjustment. The majority of existing drugs for atherosclerosis targeting the NLRP3 signaling pathway target IL-1, whereas drugs targeting the critical link of potassium efflux are relatively new. This review discusses the NLRP3 inflammatory corpuscle as a critical regulator of the immunological inflammatory pathway in atherosclerosis. Moreover, current knowledge on NLRP3 inflammatory corpuscle start and activation pathways were integrated, emphasizing potassium-involved outflow-related proteins. We highlight potential treatment approaches for NLRP3 inflammatory corpuscle pathways, specifically targeting potassium outflow channels of targeted drugs. Collectively, these insights indicate that targeting the NLRP3 inflammatory corpuscle is a vital anti-inflammatory therapy for treating atherosclerosis.
The role of molecular-biological characteristics of the organism in the development of professional sensorineural hearing loss
Authors: Funtikova Inna S. , Smirnova Elena L. , Poteryaeva Elena L. , Maksimov Vladimir N.
Published: July 2022

The researchers have analyzed the data available in domestic and foreign literature sources on the modern representation and the role of molecular biological features of the body in the development of professional sensorineural hearing loss is carried out. Genetically determined sensorineural hearing loss occurs twice as often in developed countries as in underdeveloped ones. Hearing impairment affects up to 30% of the global community, and 70 million people are deaf. Modern scientists devote their research to the study of the contribution of genetic factors in the formation of phenotypic features of the development and course of a number of occupational diseases. The analysis of genetic markers associations with occupational diseases makes it possible to identify groups of people with an increased risk of developing certain diseases among workers and to develop timely preventive measures. The results of the literature analysis made it possible to systematize the data on the study of the influence of molecular biological characteristics of the body on the formation of sensorineural hearing loss. The researchers presented the data on the studied candidate genes of predisposition to noise-induced sensorineural hearing loss. An in-depth analysis of the results of recent studies shows that the main targets in the analysis of genetic factors of predisposition to professional sensorineural hearing loss are genes encoding proteins of the systems of activation and regulation of the heat shock factor, neutralization of reactive oxygen species and transmission of signals of the immune system. Ethics. The authors have conducted the study in compliance with the ethical principles of conducting medical research with the participation of a person as a subject; personal responsibility of the authors for the conclusions and results obtained in the study; confidentiality, non-proliferation of information; scientific validity of the research methods and techniques used; objectivity in the interpretation of results, conclusions; professional competence (self-respect and self-restraint).
Level of Motivation and Adoption of Innovation at Pig Farming in Southwest Sumba Regency
Authors: Padu H. U. , Nalle A. A. , Nono O. H. , Lalus M. F. , Sembiring S.
Published: July 2022

The development of pig farming aims to support the economy of the people in the Southwest Sumba Regency. Pigs in this area have a very high cultural value, so they have promising potential and prospects in the future. The problem is that the maintenance system is still semi-extensive and tends to be traditional. This situation can be related to the motive in trying and efforts to adopt an innovation. This study aimed to analyze the level of motivation and the factors that influence the adoption of innovation in raising pigs. The research method used a survey method with direct observation in the field. They are determining the area using the multistage cluster random sampling method obtained from sample sub-districts, namely Tambolaka District (Tambolaka City and Wee Londa) and South Wewewa District (Tena Teke Village and Delo). The research material was 120 pig farmers taken by purposive random sampling. The measured variables include the motivation to raise livestock using a Likert scale and factors influencing innovation adoption using multiple linear regression tests. The software used is Eviews 10. The study results show that: 1) Most of the pig breeders in Southwest Sumba Regency are based on high economic, social, and entertainment motives in pig farming. 2) The regression results show that the variables that have a significant effect on the level of adoption with a prob value below the significant level of 0.05 are the variables of motivation and access to information. While the variables that have no significant effect on the level of innovation adoption with a prob value above the significant level of 0.05 are the variables of age, education level, family dependents, livestock experience, number of livestock, and accessibility. This study concludes that business motives and adoption of innovations affect the success or failure of pig-rearing businesses in the Southwest Sumba district.
Differential expression of EWSR1 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding EWS RNA-binding protein 1, EWSR1, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. EWSR1 was also differentially expressed in the brain metastases of patients with brain metastatic breast cancer. EWSR1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of EWSR1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. EWSR1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Differential expression of ST14 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding suppression of tumorigenicity 14, ST14, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. ST14 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ST14 in primary tumors of the breast was correlated with overall survival in human breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ST14 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
The crab that hoaxes for a mate
Authors: AISDL Mindsponge
Published: July 2022

If you have ever given up pursuing your crush because you think that your rival’s appearance is more good-looking and his gesture is more romantic than you, the fiddler crab can teach you a valuable lesson.
Differential expression of RBBP4 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding RB binding protein 4, chromatin remodeling factor, RBBP4, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. RBBP4 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. RBBP4 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of RBBP4 in primary tumors of the breast was correlated with overall survival in patients with basal subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. RBBP4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Laporan Hasil Observasi di SD Inpres Manggala
Authors: Harianti
Published: July 2022

Bimbingan adalah suatu pemberian bantuan kepada individu yang dilakukan secara bersinambungan supaya individu tersebut dapat memahami dirinya sendiri sehingga dia sanggup mengarahkan dirinya dan dapat bertindak secara wajar sesuai dengan tuntutan dan keadilan sekolah, keluarga, masyarakat an kehidupan
Metabolization and Sequestration of Plant Specialized Metabolites in Insect Herbivores: Current and Emerging Approaches
Authors: Jeckel Adriana Moriguchi , Beran Franziska , Züst Tobias , Younkin Gordon , Petschenka Georg , Pokharel Prayan , Dreisbach Domenic , Ganal-Vonarburg8 Stephanie Christine , Robert Christelle Aurélie Maud
Published: July 2022

Herbivorous insects encounter diverse plant specialized metabolites (PSMs) in their diet, that have deterrent, anti-nutritional, or toxic properties. Understanding how they cope with PSMs is crucial to understand their biology, population dynamics, and evolution. This review summarizes current and emerging cutting-edge methods that can be used to characterize the metabolic fate of PSMs, from ingestion to excretion or sequestration. It further emphasizes a workflow that enables not only to study PSM metabolism at different scales, but also to tackle and validate the genetic and biochemical mechanisms involved in PSM resistance by herbivores. This review thus aims at facilitating research on PSM-mediated plant-herbivore interactions.
I2P, X-Files season 10, video game writing credits (Historiography V:3)
Authors: Akmut Camille
Published: July 2022

Computer science and technology : historiography V (3)
Differential expression of GRHL2 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding grainyhead-like transcription factor 2, GRHL2, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. GRHL2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of GRHL2 in primary tumors of the breast was correlated with overall survival in patients with normal-like subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. GRHL2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Spatial Interaction Modelling: A Manifesto
Authors: Rowe Francisco , Lovelace Robin , Dennett Adam
Published: July 2022

Spatial interaction models (SIMs) are a core tool in spatial data modelling to predict spatial flows and understand their underpinning factors. SIMs have been applied to provide data insights and support decision making in multiple settings, notably in transport, human mobility, migration and epidemiology. While considerable progress has been made on advancing the theoretical and methodological underpinnings of SIMs, key challenges remain to facilitate the application of SIMs, extend existing modelling approaches, and leverage the opportunities afforded by Big Data. We identify three key challenges: reproducibility, calibration and Big Data modelling. We propose a blueprint to tackle these challenges by identifying four areas of development: (1) to enable essential infrastructure to facilitate the training, calibration and reproducibility of SIMs; (2) to embrace modelling frameworks to capture spatial, temporal and population heterogeneity; (3) to enhance statistical inference to accommodate Big Data analysis; and, (4) to integrate data science approaches to enhance SIM-generated predictions and statistical inference
Differential expression of GSPT1 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding G1 to S phase transition 1, GSPT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. GSPT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of GSPT1 in primary tumors of the breast was correlated with overall survival in patients with luminal A and HER2+ subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. GSPT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Communicating climate change as a generational issue: Experimental effects on youth worry, motivation and belief in collective action
Authors: Timmons Shane , Andersson Ylva , Lunn Peter D
Published: July 2022

Generations differ in their contribution to climate change and susceptibility to its effects. Contextualising climate change as an intergenerational issue may therefore alter public engagement. We report a pre-registered, online experiment with a youth sample (N = 500, aged 16-24 years) in Ireland that tested whether highlighting generational differences in descriptions of climate change affects (i) worry about climate change, (ii) perception of others’ worry, (iii) belief in collective action and (iv) pro-environmental intentions. We also tested the effect of correcting young people’s misperceptions about how concerned older generations (aged 40+) are. The generational narrative amplified self-reported worry about climate change, from 5.42 (SD = 1.45) on a 7-point rating scale in the control group to 5.76 (SD = 1.18) among those who read the generational narrative (d = 0.26). Those who read the generational narrative also believed their close friends (M = 5.14, SD = 1.32) and other peers (M = 5.28, SD = 1.19) were more worried than those who read the control narrative (M = 4.85, SD = 1.48 and M = 5.03, SD = 1.19, respectively; ds = 0.20). There were no significant effects of contextualising climate change as an intergenerational issue on perceived worry among older people, belief in collective action or pro-environmental intentions. Providing accurate information on older people’s worry, however, boosted belief in collective action, particularly for the majority who initially underestimated it (M = 4.22 out of 7, SD = 1.14 vs. M = 4.63, SD = 1.18, d = 0.36). The results have implications for communications with young people about climate change. Correcting underestimations of concern about climate change between socio-demographic subgroups may help to foster engagement.
The basic level of abstraction is prioritized in early neural representations of objects
Authors: Greene Michelle , Rohan Alyssa M.
Published: July 2022

The same object can be described at multiple levels of abstraction (“parka”, “coat”, “clothing”), yet human observers consistently name objects at a mid-level of specificity known as the basic level. Little is known about the temporal dynamics involved in creating neural representations that prioritize the basic level, nor how these dynamics change with evolving task demands. In this study, observers viewed 1080 objects arranged in a three-tier category taxonomy while 64-channel EEG was recorded. Observers performed a categorical one-back task on the basic or subordinate levels in different recording sessions. We used time-resolved multiple regression to assess the utility of superordinate-, basic-, and subordinate-level categories across the scalp. We found robust use of basic-level category information starting about 80 ms after stimulus onset. Although we observed an earlier peak in posterior electrodes (168 ms) than in anterior (313 ms), the effect was observed in all regions of interest. In addition, we found that basic level feature use was negatively correlated with superordinate feature use, suggesting a competitive mechanism that sharpens category representations at the basic level. Task differences were not evident in the first 200 ms of processing but favored the task-relevant features in the 201-400 ms window. Together, this work demonstrates that the basic-level supremacy effect originates in early perceptual processing, congruent with results that show that basic-level categorization is an automatic and obligatory process.
The W.E.I.R.D. Microcosm of Microaggression Research: Toward a Cultural Psychological Approach
Authors: Bettache Karim
Published: July 2022

Microaggression research has made great strides over the past decade, while steadily pushing itself into mainstream psychological science. Yet, the field remains firmly situated within the North American (W.E.I.R.D.) cultural context. Correspondingly, recurring criticisms against the validity of microaggressions are often rooted in individualist, decontextualized understandings of behavior. While their rebuttals are often grounded in a philosophical and reflective understanding of the cultural context. In this article, I put forward that (a) the enactments and appraisals of microaggressions are the behavioral results of the cognitive salience of cultural schemas; (b) that cultural schemas are informed by cultural ideologies, underlining their methodological and empirical relevance for future research; and (c) that cultures are dynamic by highlighting the effects of (geo-)political events on the content of cultural schemas which may moderate the perception and enactment of microaggressions. As such, I argue that a cultural psychology of microaggressions may help to de-pathologize the individual by situating behavior in its cultural context, while at the same time necessitating the inclusion of communities residing in non-W.E.I.R.D. societies.
MSc Health Psychology Poster Presentation (Preliminary Research): Using the COM-B to explore the barriers and facilitators to physical activity and exercise in adults from ethnic minorities in the UK living with chronic pain
Authors: Tafreshi Mehrad
Published: July 2022

A poster presenting preliminary research of an MSc dissertation on using the COM-B to explore the barriers and facilitators to physical activity and exercise in adults from ethnic minorities in the UK with chronic pain.
Do attitudes about and behaviors towards people who enhance their cognition depend on their looks?
Authors: Siegel Charlie , Workman Clifford Ian , Humphries Stacey , Chatterjee Anjan
Published: July 2022

Public attitudes towards cognitive enhancement––e.g., using stimulants like Adderall and Ritalin to improve mental functioning––are mixed. Attitudes vary by context and prompt ethical concerns about fairness, obligation, and authenticity/character. While people may have strong views about the morality of cognitive enhancement, how these views are affected by the physical characteristics of enhancers is unknown. Visible facial anomalies (e.g., scars) bear negatively on perceptions of moral character. This pre-registered study (https://osf.io/uaw6c/) tested the hypothesis that such negative biases against people with facial anomalies extend to moral beliefs surrounding their use of cognitive enhancement. In an online survey, 941 participants made moral judgments in response to a vignette about a person who had to decide whether or not to enhance. The vignette was accompanied by a face photograph that ostensibly depicted the potential enhancer and either did or did not have visible anomalies. Participants then learned whether the person ultimately decided to enhance. Next, participants played a modified Trust Game with, they were told, the person from the photograph/vignette. Participants judged enhancement to be less fair and enhancers less authentic if they had facial anomalies, while effects on judgments of moral obligation and on behavior were not detected. These findings extend previous work showing that people with visible differences are subject to an “anomalous-is-bad” stereotype that has negative consequences for perceptions of their moral character. While anomalous faces were judged more harshly, these judgments did not appear to affect behavior. These results are discussed in relation to discrimination and policy.
The Mobility Effects Hypothesis: Past, Present, and Future
Authors: Zang Emma , Sobel Michael , Luo Liying
Published: July 2022

We discuss hypotheses researchers have put forth to explain how outcomes of socially mobile and immobile individuals might differ and/or how mobility experiences are related to outcomes of interest. Next, we examine the methodological literature on this topic, culminating in the development of the diagonal mobility model (DMM, also called the diagonal reference model in some studies), the primary tool of use since the 1980's (Sobel 1981). We then discuss some of the many applications of the DMM. Although the model was proposed to examine the effects of social mobility on outcomes of interest, the estimated relationships between mobility and outcomes that researchers have called mobility effects are more appropriately regarded as partial associations. When mobility is not associated with outcomes, as is often found in empirical work, the DMM provides a parsimonious quantitative description of the empirical regularity that on average, the responses of mobile individuals tend to lie between those of immobile individuals in the associated origin and destination states. Therefore we briefly develop several generalizations of the current DMM that future researchers should also find useful. Finally, we propose new estimands of mobility effects, based on the explicit notion that a unit effect of mobility is a comparison of an individual with herself under two conditions, one in which she is mobile, the other in which she is immobile, and we discuss some of the challenges in identifying such effects.
Wie politisch ist eine Blumenwiese? Biodiversität und Umweltgerechtigkeit als Herausforderung für transformative Bildungsprozesse in der Sozialen Arbeit
Authors: Frieters-Reermann Norbert
Published: July 2022

Der Beitrag befasst sich mit der politischen Dimension von Biodiversität im Kontext transformativer Bildungsprozesse. Im Fokus steht dabei das Forschungs-und Transferprojekt „NaBiKo – Naturerleben ermöglichen. Biodiversität schützen. Kompetenzentwicklung im Bereich einer Bildung für nachhaltige Entwicklung fördern“, welches auf Bedarfe im Kontext von Umweltgerechtigkeit und Umweltbildung und konkreten Natur- und Biodiversitätserfahrungen in einkommensschwachen Milieus reagiert.
Is Oral Cancer predictable with miRNA: A Review
Authors:   Department of Dental Research and Implantology Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO) New Delhi110054, India, Muktawat Kirtika
Published: July 2022

Oral cancer 6th most common cancer worldwide. Main contributing factor for oral cancer is tobacco chewing, smoking and alcohol consumption. The 5-year survival rate for oral cancer is approximately 50%. This due to late detection of oral cancer. miRNA (micro Ribo Nucleic Acid) is small noncoding RNA. Its functions are in RNA silencing and post-transcriptional regulation of gene expression miRNA can be used as early diagnostic tool. This review aims to present the fundamental aspects of microRNA in oral squamous cell carcinoma (OSCC), oral premalignant lesions and progression of premalignant lesion to oral cancer. With help of miRNA, we can not only predict oral cancer, but also prediction of transformation of oral premalignant lesion to oral squamous carcinoma. Specific miRNAs are dysregulated in Oral cancer, oral Premalignant lesion and in progression of premalignant lesion to OSCC. Specific miRNAs are dysregulated in oral cancer, oral premalignant lesion and in progression of premalignant lesion to OSCC. In oral cancer miRNA-223, miRNA-211, miRNA182-5p, miRNA-450a are upregulated in comparison to healthy controls. miRNA-1290, miR-1246, miR-1258, miRNA-199a-5p, miRNA-495 are downregulated in oral cancer. In premalignant oral lesion miRNA-146a and miRNA-155 are upregulated. We can predict transformation of premalignant lesion to oral cancer because miR21, miR-181b are upregulated and miR-345 downregulated.
COMPARATIVE ANALYSIS OF MARKET OVERREACTION IN INDONESIA AND SINGAPORE STOCK EXCHANGE 2016-2019
Authors: Meiliani Mutia , Puspita Dian , Tarigan Mida , Fathoni Ahmad Fauzan
Published: July 2022

This study aims to determine whether there is a market overreaction phenomenon in the Indonesia Stock Exchange which is classified as an emerging market and the Singapore Stock Exchange which is classified as a developed market. This research was conducted in a weekly period during 2016-2019. This study uses sample included in the LQ-45 index for the Indonesia Stock Exchange and the top 30 market cap for the Singapore Stock Exchange. This research found that there was a market overreaction in the Indonesia Stock Exchange, especially the loser portofolio which experienced the strongest reversal. Meanwhile, the significance value in the one sample t-test for the average cumulative abnormal return difference value is not significance. While the results of research on the Singapore Stock Exchange found no market overreaction phenomenon as indicated by a negative and insignificance average cumulative abnormal return difference. The result showed that the Indonesia Stock Exchange has not been efficient where investors tend to overreact in responding to information while investors on the Singapore Stock Exchange are rational.
THE EFFECTS OF SALES GROWTH AND TOTAL ASSETS TURN OVER ON COMPANY VALUE WITH PROFITABILITY AND DEBT POLICY AS MEDIATION VARIABLES (CASE STUDY ON TRANSPORTATION COMPANY LISTED ON THE IDX FOR 2015-2018 PERIOD)
Authors: Andriani Vera , Haryetti Haryetti , Fathoni Ahmad Fauzan , Paramitha Anggia
Published: July 2022

This study aims to test and seek empirical evidence of the factors that influence company value. The factors tested in this study include Sales Growth and Total Asset Turn Over. Researcher adds Profitability and Debt Policy as mediating variables in this study. The population of this research is transportation companies listed on the Indonesia Stock Exchange in the 2015-2018 period. The research sample was selected using purposive sampling criteria so that 25 transportation companies were selected that were listed consecutively on the Indonesia Stock Exchange starting from the 2015-2018 period. To examine the factors that contribute to company value, this study uses path analysis and uses SPSS Statistics version 23 as an analysis tool. The results of this study indicate that Sales Growth and Total Asset Turn Over have a significant effect on Profitability, Sales Growth and Total Asset Turn Over have a significant effect on Debt Policy, Total Asset Turn Over and Debt Policies have a significant effect on Company Value. Meanwhile, Sales Growth and Profitability have no significant effect on Company Value. Debt policy as a mediating variable is able to mediate the effect of the dependent variable on the independent variable in this study. Meanwhile, Profitability as a mediating variable is not able to mediate the effect of the dependent variable on the independent variable in this study.
The Effect of Business Risk, Firm Size and Good Corporate Governance on Company Performance with Capital Structure as an intervening variable (Empirical Study on companies listed in the Business-27 Index on the IDX for the 2016-2020 period)
Authors: Oktariani Siska
Published: July 2022

ABSTRACT: This study aims to analyze the effect of business risk, company size, good corporate governance on company performance and analyze the indirect effect of business risk, company size, good corporate governance on company performance with capital structure as an intervening variable. The population of this study includes all companies that are members of the Bisnis-27 index as many as 27 companies. The sampling technique used purposive sampling method with the number of samples that met the criteria as many as 14 companies. Partial Least Square (PLS) is used as a method to analyze the data that has been obtained. The results showed that firm size and good corporate governance had a significant effect on capital structure, while business risk had no effect on capital structure. Business risk, company size, and good corporate governance have no effect on company performance. For indirect testing, it is proven that company size and good corporate governance have an indirect effect on company performance through capital structure as an intervening variable, while business risk has no effect on company performance through capital structure as an intervening variable.