bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevated and fluctuating TyG and LAP trajectories are associated with cardiometabolic multimorbidity development in midlife: the CARDIA study
Authors: Zhou Lingqu , Wang Junjie , Zhou Zirui , Wang Liangjiao , Guo Qi , Zeng Hui , Zhong Ziyue , Zhang Yinyin
Published: December 2024

Background
Insulin resistance and central obesity are major risk factors for cardiometabolic diseases. The triglyceride-glucose index (TyG) and lipid accumulation product (LAP) are markers that independently predict cardiometabolic risk. However, their combined long-term trajectories and impact on cardiometabolic multimorbidity (CMM) development remain unclear.
Methods
This cohort study utilized data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, which tracked 3,467 participants at baseline. Dual-trajectory of TyG and LAP were identified using a group-based dual-trajectory model. Cox proportional hazards models were employed to assess the relationships between dual-trajectory groups and primary cardiometabolic outcomes, including first cardiometabolic disease (FCMD), CMM (two or more conditions such as type 2 diabetes, coronary heart disease, or stroke), and all-cause mortality. Multi-state models were performed to assess the associations of dual-trajectory with CMM development.
Results
The study included 3,467 participants with a mean age of 25.08 years (SD = 3.59). Of these, 43.4% (n = 1,505) were male, and 53.2% (n = 1,561) were White. Three distinct dual-trajectory groups were identified: low-increasing (61.5%), high-amplitude fluctuation (7.6%), and high-increasing (30.9%). After multivariate adjustment, compared with the low-increasing group, the high-amplitude fluctuation group exhibited significantly higher risks for FCMD (hazard ratio [HR] 1.38, 95% confidence interval [CI]: 1.08–1.77), CMM (HR 2.63, 95% CI: 1.21–5.71), and all-cause mortality (HR 2.16, 95% CI: 1.30–3.56), as well as elevated risks for transitions from baseline to FCMD (HR: 1.39, 95% CI: 1.09–1.78), FCMD to CMM (HR: 2.31, 95% CI: 1.16–4.62), CMM to death (HR: 3.45, 95% CI: 1.13–10.51). The high-increasing group showed similar results.
Conclusions
Elevated and fluctuating trajectories of TyG and LAP from early adulthood are associated with increased risks of CMM development in midlife.
A Methodological Framework for the Development and Validation of Reliable Artificial Intelligence in Embryo Evaluation
Authors: Gilboa Daniella , Garg Akhil , Shapiro Maya , Meseguer Marcos , Amar Yuval , Lustgarten Nicole , Desai Nina , Shavit Tal , Silva Vladimiro , Papatheodorou Achilleas , Chatziparasidou Alexia , Angras Sameer , Lee Jae Ho , Thiel Larissa , Curchoe Carol Lynn , Tauber Yishay , Seidman Daniel S.
Published: December 2024

Background
Artificial intelligence (AI) models analyzing embryo time-lapse images have been developed to predict the likelihood of pregnancy following in vitro fertilization (IVF). However, limited research exists on methods ensuring AI consistency and reliability in clinical settings during its development and validation process. We present a methodology for developing and validating an AI model across multiple datasets to demonstrate reliable performance in evaluating blastocyst-stage embryos.
Methods
This multicenter analysis utilizes time-lapse images, pregnancy outcomes, and morphologic annotations from embryos collected at 10 IVF clinics across 9 countries between 2018 and 2022. The four-step methodology for developing and evaluating the AI model include: (I) curating annotated datasets that represent the intended clinical use case; (II) developing and optimizing the AI model; (III) evaluating the AI’s performance by assessing its discriminative power and associations with pregnancy probability across variable data; and (IV) ensuring interpretability and explainability by correlating AI scores with relevant morphologic features of embryo quality. Three datasets were used: the training and validation dataset (n = 16,935 embryos), the blind test dataset (n = 1,708 embryos; 3 clinics), and the independent dataset (n = 7,445 embryos; 7 clinics) derived from previously unseen clinic cohorts.
Results
The AI was designed as a deep learning classifier ranking embryos by score according to their likelihood of clinical pregnancy. Higher AI score brackets were associated with increased fetal heartbeat (FH) likelihood across all evaluated datasets, showing a trend of increasing odds ratios (OR). The highest OR was observed in the top G4 bracket (test dataset G4 score ≥ 7.5: OR 3.84; independent dataset G4 score ≥ 7.5: OR 4.01), while the lowest was in the G1 bracket (test dataset G1 score < 4.0: OR 0.40; independent dataset G1 score < 4.0: OR 0.45). AI score brackets G2, G3, and G4 displayed OR values above 1.0 (P < 0.05), indicating linear associations with FH likelihood. Average AI scores were consistently higher for FH-positive than for FH-negative embryos within each age subgroup. Positive correlations were also observed between AI scores and key morphologic parameters used to predict embryo quality.
Conclusions
Strong AI performance across multiple datasets demonstrates the value of our four-step methodology in developing and validating the AI as a reliable adjunct to embryo evaluation.
Genome assisted gene-flow rescued genetic diversity without hindering growth performance of inbred coho salmon (Oncorhynchus kisutch) population selected for high growth phenotype
Authors: Kobayashi Junya , Honda Ryo , Hosoya Sho , Nochiri Yuki , Matsuzaki Keisuke , Sugimoto Koichi , Nagano Atsushi J. , Kumagaya Akira , Kikuchi Kiyoshi , Kurokawa Tadahide
Published: December 2024

Selective breeding is a powerful tool for improving aquaculture production. A well-managed breeding program is essential, as populations can otherwise lose genetic diversity, leading to reduced selection response and inbreeding excesses. In such cases, genetic diversity in broodstock must be restored by introducing individuals from external populations. However, this can reduce the accumulated genetic gains from selective breeding. On the other hand, selectively introduction of individuals with superior phenotypes will allow restoration of genetic diversity without sacrificing these gains. In this study, we demonstrated this possibility using a selectively bred (SB) and a randomly bred (RB) population of coho salmon (Oncorhynchus kisutch). Forty males with superior growth were selected from RB population using genomic selection and crossed with 127 randomly collected females from SB to produce a newly bred (NB) population. Genetic diversity, assessed from population statistics such as effective number of alleles, allele richness, and observed heterozygosity of 11 microsatellite markers, was higher in NB than in SB and RB. Additionally, folk length and body weight were compared among the three populations after a 12-month communal culture from fertilization. The least-squares means of folk length and body weight were similar between NB (164.9 mm and 57.9 g) and SB (161.1 mm and 53.7 g), while both were significantly larger than those of RB (150.4 mm and 43.0 g). Our results highlight the effectiveness of the genome-assisted gene flow in restoring the genetic diversity of SB populations without compromising their accumulated genetic gain in growth.
Enhancing storability of Etmany guava (Psidium guajava L.) with edible coating materials
Authors: Hussein Shams A. , Ghany Nazmy A. Abdel , Bondok Ahmed , Nasser Mohamed A.
Published: December 2024

Guava is a tropical fruit that can be consumed unpeeled. However, it is prone to physical and biological deterioration during distribution and storage. The aim of this study applies an edible coating method to minimize quality loss, biological deterioration and postharvest spoilage, to extend shelf-life in cultivar " Etmany" guava. Guava was coated by chitosan and edible oil such as Moringa oil, lemon grass oil, Marjoram oil, Rosemary oil. Chitosan at 2% and moringa oil at 1% and 2% extended the cold storage of fruits by up to 24 days. Moringa oil treatment at 1% and 2% resulted in less weight loss than 1% chitosan on day 24 of storage, with the fruits exhibiting superior quality characteristics (total soluble solids, L-Ascorbic Acid, total sugars, reduced and non-reduced sugars). The results indicated that H2O2 levels in fruits treated with 2% Chitosan and 1% or 2% moringa oil were lower than in other treatments, attributed to enhanced peroxidase (POD) enzyme activity. Moreover, chitosan and oils coating substantially decreased bacteria and yeasts/molds on the fruit. Generally, moringa oil was the best treatment that increased the physiological and chemical characteristics in addition reduced the post-harvest disease soilage.
Nonlinear Adaptive Controller Design for Frequency Variation in Pulse Width Modulation for DC-DC Buck Converter via Experimental Evaluation
Authors: Eghlim Armin Lotfi , Basci Abdullah
Published: December 2024

This paper presents a novel adaptive backstepping control to deal with the frequency variations of Pulse Width Modulation signals in DC-DC buck converters. The traditional control methods, such as Sliding Mode Control and Feedback Linearization, are prone not to maintain stable output voltage when the input changes significantly and unforeseen switching frequency variations that eventually lead to system instability. To overcome these limitations, the adaptive backstepping controller is designed to handle the estimation and compensation of the switching frequency variations to ensure robust voltage regulation. Practical experiments are performed to validate the performance of the controller using an ESP32-S2 microcontroller; in addition, dynamic and steady-state responses show their effectiveness in keeping stability under different operating conditions such as load variations, input voltage fluctuations, and random switching frequency variations. The suggested approach not only strengthens the system’s stability and robustness but also decreases the chattering and steady-state errors associated with traditional control methods. These findings indicate the adaptive backstepping control technique provides a credible solution for frequency variation control in power electronic systems, which are ideal for renewable energy systems, electric vehicles, and other high-performance electronics.
Factors Associated with Abnormal Lung Function among University Students, Case of University of Rwanda (UR)
Authors: Leonidas Mvuyekure , Kevin Nwanna , jururyishya Gasana bisetsa
Published: December 2024

Background: Determinants of abnormal lung function among students have not been evaluated. COPD is estimated to have contributed to 3 million deaths worldwide, which is 5% of all fatalities, and over 90% of these deaths occurred in low- and middle-income countries (LMICs), with a global prevalence of 10.3%. A recent study in Rwanda found a COPD prevalence of 4.5%. This study aims to find the “Factors associated with abnormal lung function among university students in Kigali—Rwanda”.
Methods: A Cross-sectional study design and administered questionnaire with a minimum sample size of 220 subjects was used. Spirometry for lung function tests was used to identify abnormalities. A statistical data analysis method was employed by using STATA Version 15.1. Univariate, bivariate, and Chi-square were used. Multivariate logistic regression analysis assessed which independent variable was associated with a dependent variable.
Results: The analysis of this study showed that the high proportion was for female (54.09%). The median age was 23 years (18-29). Regarding marital status all were single. The factors for abnormal lung function were varied and were dominated by building characteristics.The prevalence of abnormal lung function was higher among students (20.9%), almost 4times of the national rate. This prevalence was associated with frequency of window opening (OR:7.06,CI: 1.27-39.30, P=0.025), freshness of air(OR:4.78, CI: 1.76-12.99, P= 0.002) and physical well-being (OR: 4.5; CI: 1.77-11.45, P=0.002).
Conclusion: The prevalence of abnormal lung function showed that it is a problem for public health that needs excellent consideration for the associated factors.
O-GlcNAcylation with ubiquitination stabilizes METTL3, promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer
Authors: Wang qiuhong , Wei Dong , Li Chunman , Yang Xiawei , Su Kun , Wang Tao , Zou Renchao , Wang Lianmin , Cun Dongyun , Tang Bo , Wu Tao
Published: December 2024

Background: Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in m6A regulation. Although ferroptosis is important in cancer therapy, the regulatory mechanism of METTL3 in pancreatic cancer and its potential for regulating ferroptosis as a treatment remain unclear.
Methods: The relationship between METTL3 and gemcitabine resistance and ferroptosis was investigated through in vitro and in vivo functional gain and loss experiments, while the target genes of METTL3 were identified using siRNA and pharmacological inhibitors to analyze the impact of O-GlcNAcylation on METTL3's stability and ubiquitination modification.
Results: We found that O-GlcNAcylation interferes with ubiquitination-mediated regulation of METTL3 stability in pancreatic cancer cells, further clarifying its O-GlcNAcylation site and ubiquitination modification type. METTL3 regulates ferroptosis and Gemcitabine resistance by promoting HMGB1 degradation in a manner dependent on m6A-YTHDF2.
Conclusion: Our study findings clearly demonstrate that METTL3 promotes pancreatic cancer cell proliferation and drug resistance to gemcitabine. This highlights the role of O-GlcNAcylation in stabilizing METTL3 expression and degrading HMGB1 through a m6A-YTHDF2-dependent mechanism, thereby inhibiting ferroptosis in pancreatic cancer cells. Furthermore, targeting HMGB1 while coordinating gemcitabine and RSL3 significantly suppresses pancreatic cancer tumor growth. These results provide valuable insights for the treatment of pancreatic cancer.
A Comparison of Optimization Techniques for Large-scale Allocation of Soybean Crops
Authors: CHEN Mathilde , KATSIRELOS George , MAKOWSKI David , TONDA Alberto
Published: December 2024

The optimal allocation of crops to different parcels of land is a problem of paramount practical importance, not only to improve food and feed production, but also to address the challenges posed by climate change. However, this optimization problem is inherently complex due to the large number of agricultural parcels available which generates a vast search space that renders traditional optimization techniques impractical. Moreover, as maximizing average production may generate solutions characterized by high year-by-year instability and lead to large and unrealistic cultivated areas, it is necessary to optimize crop allocation considering several objectives at the same time. In order to tackle this complex optimization problem, we propose a multi-objective approach, simultaneously maximizing the average production, minimizing the year-on-year production variance, and minimizing the total cultivated surface. The approach exploits an established multiobjective evolutionary algorithm, and employs a machine learning model able to predict crop production from weather and soil conditions, trained on historical data, making it possible to tackle allocation problems of large size. As a reference, we also present a comparison with a quadratic programming algorithm specifically tailored to the target problem. A case study focusing on the allocation of soybean crops in the European continent for the years 2000-2023 shows that the proposed methodology is able to identify informative trade-offs between the conflicting objectives, and identify realistic and meaningful crop allocations for supporting stakeholders’ decisions.
On the rank of combinatorial sparse random matrices
Authors:   , Rolvien Maurice
Published: December 2024

We determine the asymptotic normalized rank of a random matrix $\vA$ over an arbitrary field with prescribed numbers of non-zero entries in each row and column.
As an application we obtain a formula for the rate of low-density parity check codes.
This formula vindicates a conjecture of Lelarge (2013).
The proofs are based on coupling arguments and a novel random perturbation, applicable to any matrix, that diminishes the number of short linear relations.
We derive a sufficient condition for a sparse random matrix with given numbers of non-zero entries in the rows and columns having full row rank.
The result covers both matrices over finite fields with independent non-zero entries and $\{0,1\}$-matrices over the rationals.
The sufficient condition is generally necessary as well.
We provide a simplified proof of the random $k$-XORSAT satisfiability threshold theorem.
As an extension we also determine the full rank threshold for sparse random matrices over finite fields with precisely $k$ non-zero entries per row. This complements a result from [Ayre, Coja-Oghlan, Gao, Müller: Combinatorica 2020]. The proof combines physics-inspired message passing arguments with a surgical moment computation.
АЛЬФОНСО Х И FECHO DEL IMPERIOВ АМЕРИКАНСКОЙ ИСТОРИОГРАФИИ 1960–1980-х гг.
Authors: Ауров О.В. , Беленький С.Б.
Published: December 2024

В статье исследованы основные тенденции эволюции интерпретаций образа короля Кастилии и Леона Альфонсо Х Мудрого (1252–1284) и его борьбы за престол Священной Римской Империи (fecho del imperio, 1256–1275) в медиевистике США, от преимущественного внимания к политической истории царствования до акцента на политике Мудрого Короля (Sabio) в области культуры. Изменение исследовательского ракурса связывается с общими условиями становления и развития американской испанистики в ХХ в., влиянием прогресса в изучении истории литературы и языка средневековой Испании на сферу исторических исследований, а также особенностями развития мировой медиевистики в указанный период.

The article deals with the evolution of interpretations of the image of Alfonso X, King of Castile and León (1252-1284) and his struggle for the throne of the Holy Roman Empire (fecho del imperio, 1256-1275) in the American Medieval Studies. These interpretations changed the focus of attention from the political history of the reign to the policy of the Learned King (El Sabio) in the field of culture. This change is explained by different kinds of influences and among them by general conditions of Hispanic Studies’ development in the 20th century, by the progress in the field of studies in Medieval Hispanic philology and linguistics and its influence on the historical studies and by the tendencies of medieval studies in the world during the mentioned period.
ГЕРОЙ ИЗ «ЛЕДЯНОГО ДОМА»: ОБРАЗ А. П. ВОЛЫНСКОГОВ ЛИТЕРАТУРНЫХ ПРОИЗВЕДЕНИЯХ 1820-1830-х гг.
Authors: Крючков Н.Н.
Published: December 2024

Статья посвящена анализу художественного образа Артемия Волынского в литературных произведениях 20-30-х гг. XIX в. Отсутствие специальных исследований о событиях аннинского царствования, недоступность исторических документов для образованной части общества, влияние романтизма предопределили литературную традицию. Созданный писателем И.И. Лажечниковым идеализированный образ казненного патриота оказался достаточно долговечен.

The paper analyzes a literary representation of Artemy Volynsky in literary works of the 1820s –1830s. The absence of special historical studies of the reign of Anna Ioannovna, the inaccessibility of historical documents for the educated part of society, and the influence of Romanticism predetermined the literary tradition.  The idealized image of the executed patriot created by I.I. Lazhechnikov turned out to be rather durable.
ИСТОРИЯ В ВОСПИТАНИИПОДРАСТАЮЩЕГО ПОКОЛЕНИЯ БРИТАНИИ XVIII ВЕКА
Authors: Айзенштат М.П.
Published: December 2024

История занимала существенное место в социально-политической жизни британцев. В то же время она не была специальным предметом в школах и университетах. На основе изучения переписки графа Честерфилда, У. Питта старшего и Ф. Френсиса в статье анализируется место истории в образовании детей в представлении родителей и опекунов о характере и содержании знаний о прошлом; а также предназначения истории для будущей карьеры.

History occupied an important place in the social and political life of Britons, but it had not been a special subject in schools and Universities. Author analyses the writings of some Whigs: the historical knowledge of their children, what and how they studied; and their views on the utility of history for their future.
ЖЕНСКАЯ ВОЙНА В БЕЛОМ ДОМЕ
Authors: Алентьева Т.В.
Published: December 2024

В статье рассматривается политический кризис при президенте Эндрю Джексоне, впервые в истории США приведший к отставке всего кабинета министров. «Джексоновская эпоха» была периодом политических инноваций американской демократии. Это – система патронажа, строгой партийной дисциплины, деятельность «кухонного кабинета», назначение на должности по принципу личной преданности. Поводом для политического кризиса послужила так называемая «война юбок», или «женская война» в Белом доме, являвшаяся отражением внутренней политической борьбы в президентском окружении. Она способствовала укреплению позиций проджексоновских сил в администрации и укреплению личной власти президента.

The article describes the political crisis in the United States during the presidency of Andrew Jackson, which for the first time in the history of that country led to the resignation of the entire Cabinet of Ministers. The «Jacksonian era» was a period of political innovation in the American democracy. There were for example: the system of patronage, strict party discipline, the «Kitchen Cabinet» appointed on the basis of personal loyalty. The reason for the political crisis was the so-called «Petticoat affair» in the White house, which was a reflection of the internal political struggle in the presidential environment. It contributed to strengthening the position of the pro-Jacksonian forces in the administration and strengthening the personal power of the President. Keywords: the USA History, 19th century, “the Jacksonian Era”, presidential administration, “the Petticoat affair”
ОЧЕНЬ КРАТКАЯ ИСТОРИЯ ЗАПАДНОЙ “ИДЕОЛОГИИ”Рец. на кн.: Petri R. A Short History of Western Ideology.A critical account. London etc.: Blomsberry, 2018
Authors: Павлов А.В.
Published: December 2024

Статья представляет собой рецензию на книгу западного историка идей Рольфа Петри, выполненную в жанре «размышления над книгой». Автор не только пересказывает ключевые тезисы Петри относительно истории «западной идеологии», но и пытается концептуализировать за него некоторые идеи, оставшиеся непроясненными из-за обильного цитирования первоисточников.

The article is a review of the monograph by a Western intellectual historian Rolf Petri, made in the genre of “reflections on the book”. The author not only retells Petri’s key theses on the history of "Western ideology", but also tries to conceptualize some ideas that have not been clarified because of the abundant quotations of primary sources.
«ПОНЯТЬ ЧЕЛОВЕКА – САМАЯ ЗАМАНЧИВАЯИ, УВЫ, НЕРАЗРЕШИМАЯ ЗАДАЧА»
Authors: Ивонина Л.И.
Published: December 2024

Статья представляет собой рецензию на книгу известного российского историка Андрея Соколова «Кларендон и его время. Странная история Эдварда Хайда, канцлера и изгнанника». В ней показаны как достоинства работы, так и ее недостатки, а также отражены дискуссионные моменты.

The article is a review of the book of the famous Russian historian Andrei Sokolov “Clarendon and his time. The Strange Story of Edward Hyde, Chancellor and Exile”. It shows both the advantages of the work, and its shortcomings, and also reflects the discussion points.
СОВРЕМЕННЫЕ ПРАВЫЕ ВО ФРАНЦИИ: КТО ОНИ?
Authors: Канинская Г.Н.
Published: December 2024

В статье рассматривается монография французского историка Жиля Ришара «История правых во Франции. С 1815 до наших дней». Это фундаментальный труд, законченный автором 5 декабря 2016 г., в момент начавшейся во Франции президентской избирательной кампании, принёсшей в мае 2017 г. ошеломительную победу Э. Мак-рону. В книге дан раскрыта эволюция «политической семьи» французских правых на протяжении четырёх веков. Показано, как трансформировались базовые ценности правых сил и партий, сделана попытка определить, что значит быть правым в XXI в.

The article deals with the monograph of the French historian Gilles Richard “The History of the right-wing forces in France. From 1815 to the present day”. This is a fundamental work completed by the author on December 5, 2016, at the time of the presidential election campaign that began in France, which in May 2017 brought a stunning and to a certain extent unexpected victory to E. Macron. The book presents a historical synthesis of the evolution of the “political family” of the French right-wing forces for four centuries. Against the general background of French and global history shows how to transform the basic values of the right political forces and parties and an attempt to determine what it means to be right in the 21st century.
Wound healing in glaucoma surgery. Part 1. Wound healing morphology
Authors: Izmailova N. S. , Petrov S. Yu. , Dzebisova A. D.
Published: December 2024

Glaucoma is a leading cause of blindness in the world. A proven condition for preventing the progression of glaucomatous optic neuropathy is to reduce intraocular pressure. Therapy begins with local hypotensive drugs; if they are ineffective, laser treatment or surgery is used. However, hypotensive intervention does not guarantee a stable hypotensive effect. Wound healing is a complex physiological dynamic process that is necessary to maintain homeostasis in the body. This process includes three interrelated phases: inflammation, fibroplasia, and remodulation (maturation) of the scar. Thе review presents various cellular mechanisms involved in the regulation of these processes and factors that contribute to excessive scarring. The review presents various cellular mechanisms involved in the regulation of these processes and contributing to excessive scarring. Current knowledge about the key factors of pathomorphological processes occurring in the filtration zone is intended to stimulate the development of new methods for prolonging the effect of filtering surgery.
Application of standard keratometry values obtained from keratotopographic mapping data to calculate the optical power of a multifocal intraocular lens
Authors: Shukhaev S. V. , Boiko E. V. , Petrosyan Yu. M. , Molodkin A. V.
Published: December 2024

Purpose of the study is to determine the zones of standard keratometry according to keratotopography data, which will allow for more accurate calculation of multifocal IOL using 10 formulas.

Material and methods. The study included 55 patients (55 eyes) who underwent phacoemulsification of cataract or refractive lensectomy with femtolaser accompaniment, implantation of multifocal IOL (Acrysof IQ PanOptix) and achieved the target refraction at different distances. Retrospective calculation of the optical power of the IOL was carried out using biometric data from OA-2000 and keratometric indicators of Pentacam (zones from 0.5 mm to 5 mm in increments of 0.5 mm on the Axial/Sagittal map centered on the apex and pupil) using 10 formulas (SRK/T, Holladay 1, Holladay 2, Haigis, Hoffer Q, Barrett 2 Universal, Olsen, Kane, EVO ver. 2.0, Hill RBF ver. 3.0). For each combination of zone/keratometry value/formula, the average error of postoperative predicted refraction, its difference from zero (Wilcoxon criterion), the median value taking into account the sign, the mean (MAE) and median (MedAE) absolute errors in calculating the spherical equivalent of the IOL, the standard deviation of the mean absolute error (SD) were calculated.

Results. All formulas had a shift to myopic refraction, except for the Haigis formula, which shifted towards hyperopia. The absence of a significant difference from zero was shown only by the Kane formula in zones 3.5, 4.5–5.0 mm when centered on the apex and in zones 0.5, 1.5, 2.5–5.5 mm when centered on the pupil. The highest values of MAE were found in Haigis and Olsen formulas, and the minimum values were observed in most formulas in the 4.5–5.0 mm zones. The lowest MedAE values in all ranges were shown by the formulas Kane, EVO, Holladay 1 and Holladay 2. The minimum SD values were found for the formulas Kane, EVO, Holladay 1 and Holladay 2.

Conclusion. The Kane formula turned out to be the most accurate in the 4.5–5.0 mm zone. This is followed by the EVO 2 and Holladay 1 formulas in the 4.0 mm zone. The Haigis formula turned out to be the least accurate. The remaining formulas can be recommended for use with SimK Pentacam data in 4.0–5.0 mm zones.
Diagnostic specifics of demyelinating optic neuritis on the idiopathic thrombocytopenic purpura
Authors: Okhotsimskaya T. D. , Eliseeva E. K.
Published: December 2024

A clinical case of optic neuritis in a patient with idiopathic thrombocytopenic purpura is presented. As a result of a comprehensive ophthalmological, clinical, instrumental and laboratory examination, objective signs of unilateral demyelinating damage of the optic nerve were revealed (according to the results of electrophysiological examinations and optical coherence tomography). A year later the patient developed a clinical symptoms of multiple sclerosis, confirmed by magnetic resonance imaging. Associations of multiple sclerosis with other autoimmune diseases are not uncommon, however, only a few cases of multiple sclerosis on the idiopathic thrombocytopenic purpura have been described in the literature. Considering that ophthalmologists in clinical practice may encounter concomitant eye diseases on the diagnosed or debuting autoimmune diseases, it is necessary to conduct an ophthalmological examination with immediate consultation of related specialists.
Ways to improve the effectiveness of uvulopalatoplasty
Authors: Knyazkov V. B.
Published: December 2024

Ronchopathy is a complex polyethological disease that has a multifactorial negative effect on the cardiovascular, respiratory and other systems of the body. Mortality in this terrible disease, most often from vascular causes and, especially, in the presence of obstructive sleep apnea syndrome, ranges from 6 to 11%, and the consequences of various complications associated with this disease increase it to 37%. The effectiveness of surgical methods of treating patients with ronchopathy is still clearly unsatisfactory, and does not allow most of them to achieve a guaranteed recovery. At the same time, the growing number of such patients, who are in dire need of effective treatment and reliable prevention of complications of this disease, encourages specialists to further search for surgical treatment methods. Surgical interventions on the soft palate in patients with ronchopathy and obstructive sleep apnea syndrome are based on the principle of injury to the palatine curtain of varying intensity (surgical, thermal, radiofrequency, laser, chemical), independent of the methods of exposure. At the same time, depending on the intensity of exposure, inflammation, necrosis or partial tissue rejection are noted and, as a result, scarring, compaction and a decrease in the volume of the palate. At the same time, the mobility of the palatine curtain should decrease, and the intensity of snoring should decrease. However, injury caused primarily to the velopharyngeal muscles often leads to hypo- and atrophy, hypotension and significant sagging of the palate, and, subsequently, to a recurrence of the disease and increased snoring. This significantly reduces the effectiveness of surgical treatment of these patients. Increasing the effectiveness of uvulopalatoplasty is one of the tasks of modern otorhinolaryngology. Ways to increase the effectiveness of uvulopalatoplasty lie in the following directions: qualitative and adequate selection for the upcoming operation; accurate determination of the level(s) of obstruction, shape and degree of collapse of the soft tissues of the upper respiratory tract; careful consideration of the structural features of the soft palate and pharynx of each individual patient; maximum reduction of surgical trauma to the tissues of the palatine curtain during surgery.
Impact of Visual Audio Media on Learning Results on Class XI Reaction Speed Material
Authors: Ratman Ratman , Walanda Daud Karel , Amalia Maryam
Published: December 2024

The study aims to describe the impact of the use of audiovisual media in the form of video learning on the learning results of students at Sigi District State High School 10. The research method is quantitative research with a type of quasi-experimental research or experimental experiment with a design pretest-posttest control group design. The differences in learning results on reaction speed between experimental and control classes are shown by the results of Wilcoxon and Mann Whitney's statistical analysis tests. The results of the Wilcoxons and Mann whitney statistical analytics tests on the post-test values of experimental classes and the control classes both show the significance values Asymp.Sig.(2-tailed) = <0,000. Because of the signification values Asymp.Sig.(2-tailed) = 0,000 < 0,05. Then from the two results of these statistical analyses it can be concluded that there is an influence of the use of audiovisual media in the form of video learning on the learning outcomes of students in SMAN 10 Sigi.
Analysis of Students' Psychomotoric Abilities in Daily Life -Based Practicum on Reaction Rate Material
Authors: Fadzliana Nanda , Kurniawati Yenni
Published: December 2024

The aim of this research is to analyzing students' psychomotor abilities in daily life -based practicums on reaction rate material. This research was carried out in the 2022/2023 academic year at Madrasah Aliyah Negeri 1 Kampar with the material Reaction Rate. The method used in this research is quantitative descriptive. The instruments used in this research were performance assessment sheets to determine students' psychomotor abilities and interviews to strengthen the data obtained. The results of data analysis show that the average psychomotor ability of students is 79.19. The highest average score obtained was in the naturalization domain with the very good category and the psychomotor ability with the lowest average score obtained was in the precision domain with the good category. The psychomotor indicator with the highest average score is assembling experimental equipment in the very good category, and the psychomotor indicator with the lowest average score is the indicator for splitting and smoothing solid substances in the good category. The psychomotor abilities of the students are mostly in the good category, which is 52% with the highest rating scale score being scale 4 with a good category, which is 59%. Daily life -based chemistry practical learning can make it easier for students to carry out practical work.
Cognitive Reframing in Anticipation and Prevention of Multiplex Threats to Critical Infrastructure
Authors: Panilov Pavel Alekseevich
Published: December 2024

The article introduces a new cognitive reframing approach to anticipating and preventing multiplex threats to critical infrastructure. In the context of constantly evolving threats, the model may increase the effectiveness of incident prevention strategies. It is visualized as a graph with nodes for concepts of cognitive reframing and edges for the connections between them. The model includes weight values that depend on the importance of each concept, as well as additional importance metrics, coefficients, and interactions. By calculating the edge weights, the authors developed a graph that illustrates the interrelationships between the concepts. The model can be applied to various scenarios as it improves cybersecurity, responds to natural disasters, and ensures the smooth operation of various systems. The model takes into account dynamic factors, multiple importance metrics, interactions, and statistical methods, which makes it flexible and adaptive. Extra factors could increase the complexity, accuracy, and adaptability of the current model. Cognitive reframing has good prospects in the field of critical infrastructure while the new model proves to be an effective threat management tool.
Marcadores moleculares na identificação de variantes genotípicas do vírus da síndrome da mancha branca em camarões Litopenaeus vannamei cultivados no Estado do Ceará
Authors:   , Cavalcanti Germana Guimarães Rebouças
Published: December 2024

A Carcinicultura no Brasil é uma atividade bastante rentável, entretanto, é sensível

a surtos de doenças, com destaque para a Doença da Síndrome da Mancha Branca (WSSD),

cujo agente causador é o Vírus da Síndrome da Mancha Branca (WSSV) que devido a sua

elevada morbidade e mortalidade, vêm acometendo cultivos de camarões em todo o mundo.

Assim, sendo o Estado do Ceará um dos principais produtores de camarão do Brasil, objetivouse estudar a incidência e a variabilidade genética do WSSV em fazendas do Estado do Ceará.

Este estudo foi organizado em três etapas, estruturados em capítulos e com objetivos

complementares. O primeiro capítulo é constituído pela construção de um referencial teórico,

no segundo capítulo é relatado a caracterização das fazendas em estudo, bem como a influência

de parâmetros de cultivo na incidência de WSSV. No capítulo três, está descrita a detecção de

amostras positivas para o WSSV e o uso de marcadores moleculares para caracterizá-las,

comparando-as em seguida com isolados de outras regiões geográficas. Por fim, o capítulo

quatro realiza uma análise in sílico das regiões gênicas amplificadas nas amostras discutidas no

capítulo três, buscando estudar as regiões variáveis do genoma do WSSV através da análise das

similaridades evolutivas e divergências ao longo do tempo, traçando um perfil filogenético.

Dessa forma, este trabalho traz dados relevantes sobre as variantes do WSSV circulantes no

Estado do Ceará, contribuindo para levantar informações, ainda limitadas, sobre a incidência

desse vírus na região Nordeste do Brasil
Gereformeerde voorbereidingsvragen voor het avondmaal
Authors: De Jong Klaas-Willem , Wassenaar Jan Dirk
Published: December 2024

In this article, the authors discuss the origin, development and practice of a set of questions the Dienstboek voor de Nederlandse Hervormde Kerk in ontwerp (1955) offers for the Lord’s Supper preparation services. In answering the questions, churchgoers profess their faith, just as they did when they sought admission to the Lord’s Supper. The editing of the questions changed over time. The questions originated in East Frisia, but in their later editing were partly stamped by the Kirchenordnung (1563) of the Palatinate. Local congregations in both most northern provinces, but especially in Groningen, have adopted the questions from Emden. The provincial synod of Groningen prescribed them in 1659, but the reception in its jurisdiction has been variable. The same was true of the questions prescribed by Synod of the Netherlands Reformed Church in 1817 for the entire country. Nowadays, they are still sporadically in use.
Death, Conflict and Scandal. A Practical Theological Study of the Role of Rituals in Congregations Following the Loss of the Minister
Authors: Steyn Marileen
Published: December 2024

Summary of PhD Thesis. This thesis was defended on October 23, 2023 at Stellenbosch University (South-Africa). Supervisors: prof. dr. Cas Wepener (Stellenbosch University, South-Africa) and prof. dr. Christo Thesnaar (Stellenbosch University, South-Africa). The Pastoral Office of the Western Cape Synod of the Dutch Reformed Church in South Africa acted as the problem owner and the funder of the research.
Zuivere, eerlijke, oprechte kerkmuziek. Leven en werk van componist en kerkmusicus Willem Vogel
Authors: Winter Christiaan
Published: December 2024

Samenvatting proefschrift. Dit proefschrift is verdedigd op 23 juni 2023 aan de Vrije Universiteit Amsterdam. Supervisors: prof. dr. August den Hollander (Vrije Universiteit Amsterdam) en prof. dr. Marcel Barnard (Protestant Theological University, Amsterdam). Co-supervisor: dr. Gerben Gritter (Conservatorium van Amsterdam).
Ballet Immemorial
Authors: Oliver Katy
Published: December 2024

In W.J.T. Mitchell’s essay “Metapictures,” Mitchell claims that Diego Velásquez’s painting Las Meninas is “a veritable whirlpool of interpretive ‘aspects,’ switching and alternating the places of painter, beholder, and model, the viewer and the viewed… The figure of the ‘whirlpool’ suggests a way of specifying (or picturing) the multistability effect in a graphic form” (75). Mitchell’s “whirlpool of interactive ‘aspects’” provides an excellent means of grafting the concept of the metapicture onto different artistic discourses—here, ballet and its counterpart, meta-ballet (75). I contend that meta-ballet has two components: it comprises both the deliberate act of referencing the balletic canon and also the process of exploring the constituent parts of the balletic tradition (gesture and bodily movement, staging, performativity, and so on) in a way that mutates normative understandings of ballet. This paper’s aims are twofold: firstly, I develop the concept of meta-ballet and apply it to the show Princess Tutu. Secondly, I explore the uniquely meta-balletic nature of ballet pantomime and bodily motion as deployed by the show. Princess Tutu is quite self-consciously a meta-ballet, making constant references to real-world ballets, ballet techniques, and balletic pantomime. Its playful re-articulations and references to the canonical Western ballets of the nineteenth century illustrate the rich possibilities within ballet’s vast and variegated archive of bodies, texts, performances, and gestures.
Gundam and the Japanese Media Mix: Novelizations, Model Kits and Statues
Authors: Kinoshita Shotaro
Published: December 2024

Mobile Suit Gundam (1979) and related texts – collectively called the Gundam franchise – revolutionized robot animation with its realistic settings, eventually gaining immense popularity through reruns and expansions into various media formats. This paper explores the Gundam series' innovative media mix strategies, including novelizations, model kits, and life-sized statues, which have each been critical to its enduring success in specific ways. For instance Gundam novelizations, particularly those by director Tomino Yoshiyuki, deviated from the TV series, incorporating mature themes and expanding the narrative universe. This approach set a precedent for media mixing in animation. Additionally, Gundam's plastic models, especially the MSV series, created a new form of “narrative consumption” where fans engaged with the broader lore of the series through detailed models. These models maintained the franchise's popularity during periods without new TV broadcasts. Finally, life-sized Gundam statues further exemplify the franchise's media mix innovation. Starting with the 2009 Tokyo installation, these statues have evolved, incorporating dynamic elements and interactive features. These installations offer a unique “pseudo-authenticity,” making the fictional Gundam universe tangible and attracting widespread attention. Overall, Gundam's pioneering media mix strategieshave not only sustained the franchise’s cultural and economic impact, but also expanded it, thus solidifying its status as a cornerstone of Japanese animation culture.
A Brief History of the Journal of Anime and Manga Studies
Authors: Tringali Billy
Published: December 2024

A brief history of the Journal of Anime and Manga Studies over our first five years of publication.
Cardiometabolic Health Intervention Using Music and Exercise (CHIME) Delivered via Telehealth to Wheelchair Users: Protocol for a Randomized Controlled Trial
Authors: Kim Yumi , Rimmer James H , Lai Byron , Oster Robert , Cowan Rachel , Young Hui-Ju , Fisher Gordon , Kim Younguk , Giannone John , Wilroy Jereme D
Published: December 2024

Background

Wheelchair users live predominantly sedentary lifestyles and have a substantially higher risk for cardiometabolic disease and mortality compared to people without disabilities. Exercise training has been found to be effective in improving cardiometabolic health (CMH) outcomes among people without disabilities, but research on wheelchair users is limited and of poor quality.

Objective

The primary aim of this study is to examine the immediate and sustained effects of a 24-week, telehealth, movement-to-music cardiovascular (M2M-C) exercise program on core indicators of CMH among adult wheelchair users compared to an active control group. The secondary aim is to explore the beneficial effects of M2M-C exercises on cardiovascular capacity, physical activity, and quality of life. Intervention components include tailored exercises and remote performance monitoring, delivered via live videoconference training by a telecoach and asynchronous videos.

Methods

This study’s design is a parallel-arm randomized controlled trial enrolling 132 physically inactive adult wheelchair users with poor cardiometabolic profiles. The M2M-C intervention group involves 24 weeks of virtual live and monitored home exercise training (3×/wk, 15-40 min/session), followed by a 12-week maintenance period where participants have access to an online media library of exercise videos. The control group involves 36 weeks of self-guided exercise through access to a media library of exercise videos, including videos for range of motion, muscle strength, and balance. The primary outcomes are cardiometabolic indicators of health, and assessors are blinded.

Results

Recruitment procedures started in January 2024 with the first participant enrolled on March 18, 2024. All data are anticipated to be collected by November 2027, and the main results of the trial are anticipated to be published by February 2028. Secondary analyses of data will be subsequently published. A total of 16 participants have been recruited as of paper submission.

Conclusions

The knowledge obtained from this trial will provide evidence to inform exercise prescriptions aimed at improving CMH among adult wheelchair users.

Trial Registration

ClinicalTrials.gov NCT05606432; https://clinicaltrials.gov/study/NCT05606432

International Registered Report Identifier (IRRID)

DERR1-10.2196/57423