Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls
Authors: Masuda Hiroki , Mori Masahiro , Hirano Shigeki , Uzawa Akiyuki , Uchida Tomohiko , Muto Mayumi , Ohtani Ryohei , Aoki Reiji , Hirano Yoshiyuki ,   Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI), Iwatsubo Takeshi , Asada Takashi , Arai Hiroyuki , Sugishita Morihiro , Matsuda Hiroshi , Ito Kengo , Senda Michio , Ishii Kenji , Kuwano Ryozo , Ikeuchi Takeshi , Sato Noriko , Sato Hajime , Shimohama Shun , Saitoh Masaki , Yamauchi Rika , Hayashi Takashi , Kobayashi Seiju , Nakano Norihito , Kanazawa Junichiro , Ando Takeshi , Takanami Chiyoko , Hareyama Masato , Hatakenaka Masamitsu , Tsukamoto Eriko , Ochi Shinji , Shoji Mikio , Matsubara Etsuro , Kawarabayashi Takeshi , Wakasaya Yasuhito , Nakata Takashi , Nakahata Naoko , Ono Shuichi , Takai Yoshihiro , Takahashi Satoshi , Yonezawa Hisashi , Takahashi Junko , Kudoh Masako , Sasaki Makoto , Matsumura Yutaka , Hirata Yohsuke , Metoki Tsuyoshi , Hayakawa Susumu , Sato Yuichi , Takeda Masayuki , Sasaki Toshiaki , Sera Koichiro , Terasaki Kazunori , Saitoh Yoshihiro , Goto Shoko , Ueno Kuniko , Sakashita Hiromi , Watanabe Kuniko , Nagata Ken , Sato Yuichi , Maeda Tetsuya , Kondoh Yasushi , Yamazaki Takashi , Takano Daiki , Miyata Mio , Komatsu Hiromi , Watanabe Mayumi , Sinoda Tomomi , Muraoka Rena , Kikuchi Kayoko , Ito Hitomi , Sato Aki , Kinoshita Toshibumi , Toyoshima Hideyo , Sato Kaoru , Sugawara Shigeki , Ito Isao , Kumagai Fumiko , Furukawa Katsutoshi , Waragai Masaaki , Tomita Naoki , Okamura Nobuyuki , Ootsuki Mari , Sugawara Katsumi , Sugawara Satomi , Mugikura Shunji , Umetsu Atsushi , Murata Takanori , Nagasaka Tatsuo , Kudo Yukitsuka , Tashiro Manabu , Watanuki Shoichi , Nishizawa Masatoyo , Tokutake Takayoshi , Ishikawa Saeri , Kishida Emiko , Sato Nozomi , Hagiwara Mieko , Yamanaka Kumi , Watanabe Takeyuki , Takasugi Taeko , Inagawa Shoichi , Naito Kenichi , Awaji Masanori , Kanazawa Tsutomu , Okamoto Kouiti , Ikeda Masaki , Yamazaki Tsuneo , Tasiro Yuiti , Nagamine Syunn , Katsuyama Shiori , Kurose Sathiko , Fukushima Sayuri , Koya Etsuko , Amanuma Makoto , Oriuti Noboru , Ujita Kouiti , Kishi Kazuhiro , Tuda Kazuhisa , Mizukami Katsuyoshi , Arai Tetsuaki , Nakajima Etsuko , Miyamoto Katsumi , Saotome Kousaku , Kobayashi Tomoya , Itoya Saori , Ookubo Jun , Akatsu Toshiya , Anzai Yoshiko , Ikegaki Junya , Katou Yuuichi , Kimura Kaori , Kuchii Ryou , Saitou Hajime , Shinoda Kazuya , Someya Satoka , Taguchi Hiroko , Tashiro Kazuya , Tanaka Masaya , Nemoto Tatsuya , Wakabayashi Ryou , Watanabe Daisuke , Takano Harumasa , Suhara Tetsuya , Shinoto Hitoshi , Shimada Hitoshi , Higuchi Makoto , Mori Takaaki , Ito Hiroshi , Obata Takayuki , Fukushima Yoshiko , Suzuki Kazuko , Izumida Izumi , Tanimoto Katsuyuki , Shiraishi Takahiro , Shiba Junko , Yano Hiroaki , Satake Miki , Nakui Aimi , Ebihara Yae , Hasegawa Tomomi , Yoshiyama Yasumasa , Kato Mami , Ogata Yuki , Fujikawa Hiroyuki , Araki Nobuo , Nakazato Yoshihiko , Sasaki Takahiro , Shimadu Tomokazu , Yoshimaru Kimiko , Matsuda Hiroshi , Imabayashi Etsuko , Yasuda Asako , Yamamoto Etuko , Nakamata Natsumi , Miyauchi Noriko , Ozawa Keiko , Hashimoto Rieko , Unezawa Taishi , Ichikawa Takafumi , Hayashi Hiroki , Yamagishi Masakazu , Mihara Tunemichi , Hirano Masaya , Watanabe Shinichi , Fukuhara Junichiro , Matsudo Hajime , Saito Nobuyuki , Iwata Atsushi , Kowa Hisatomo , Hayashi Toshihiro , Ihara Ryoko , Miyagawa Toji , Yoshida Mizuho , Koide Yuri , Samura Eriko , Fujii Kurumi , Watanabe Kaori , Orihara Nagae , Momose Toshimitsu , Kunimatsu Akira , Mori Harushi , Takahashi Miwako , Arai Takuya , Kojima Yoshiki , Goto Masami , Sarashina Takeo , Uzuki Syuichi , Katou Seiji , Sekine Yoshiharu , Takauchi Yukihiro , Kagami Chiine , Kanemaru Kazutomi , Murayama Shigeo , Nishina Yasushi , Sakaibara Maria , Okazaki Yumiko , Okada Rieko , Obata Maki , Iwata Yuko , Minami Mizuho , Hanabusa Yasuko , Shingyouji Hanae , Tottori Kyoko , Tokumaru Aya , Ichinose Makoto , Kume Kazuya , Kahashi Syunsuke , Arima Kunimasa , Tukamoto Tadashi , Tanaka Shin , Nagahusa Yuko , Sakata Masuhiro , Okazaki Mitsutoshi , Saito Yuko , Yamada Maki , Kodama Tiine , Obata Maki , Takeuchi Tomoko , Ozawa Keiichiro , Iwata Yuko , Shingyouji Hanae , Hanabusa Yasuko , Kawaji Yoshiko , Tottori Kyouko , Sato Noriko , Nakata Yasuhiro , Sawada Satoshi , Mimatsu Makoto , Nakkamura Daisuke , Tamaru Takeshi , Horiuchi Shunichirou , Arai Heii , Ota Tsuneyoshi , Kodaka Aiko , Tagata Yuko , Nakada Tomoko , Iseki Eizo , Sato Kiyoshi , Fujishiro Hiroshige , Murayama Norio , Suzuki Masaru , Kimura Satoshi , Takahashi Masanobu , Hanyu Haruo , Sakurai Hirofumi , Umahara Takahiko , Kanetaka Hidekazu , Arashino Kaori , Murakami Mikako , Kito Ai , Miyagi Seiko , Doi Kaori , Sasaki Kazuyoshi , Yamazaki Mineo , Ishiwata Akiko , Arai Yasushi , Nogami Akane , Fukuda Sumiko , Tottori Kyouko , Minami Mizuho , Iwata Yuko , Kozaki Koichi , Yamada Yukiko , Kimura Sayaka , Machida Ayako , Kobayashi Kuninori , Mizusawa Hidehiro , Sanjo Nobuo , Watanabe Mutsufusa , Ohkubo Takuya , Utashiro Hiromi , Matsumoto Yukiko , Hagiya Kumiko , Miyama Yoshiko , Shinozaki Takako , Hiraki Haruko , Shibuya Hitoshi , Ohashi Isamu , Toriihara Akira , Ohtani Shinichi , Matsui Toshifumi , Hayasaka Yu , Toyama Tomomi , Sakurai Hideki , Sugiura Kumiko , Taguchi Hirofumi , Hatashita Shizuo , Imuta Akari , Matsudo Akiko , Wakebe Daichi , Hayakawa Hideki , Ono Mitsuhiro , Ohara Takayoshi , Washimi Yukihiko , Arahata Yutaka , Takeda Akinori , Konagaya Yoko , Yamaoka Akiko , Tsujimoto Masashi , Hattori Hideyuki , Sakurai Takashi , Hisayuki Miura , Endou Hidetoshi , Satake Syousuke , Hong Young Jae , Iwai Katsunari , Yoshiyama Kenji , Suenaga Masaki , Morita Sumiko , Kachi Teruhiko , Toba Kenji , Miura Rina , Kawai Takiko , Honda Ai , Kato Takashi , Fujiwara Ken , Katou Rikio , Koyama Mariko , Fukaya Naohiko , Tsuji Akira , Shimizu Hitomi , Fujisawa Hiroyuki , Nakazawa Tomoko , Koyama Satoshi , Sakata Takanori , Yamada Masahito , Yoshita Mitsuhiro , Samuraki Miharu , Ono Kenjiro , Shinohara Moeko , Soshi Yuki , Niwa Kozue , Doumoto Chiaki , Hata Mariko , Matsushita Miyuki , Tsukiyama Mai , Takeda Nozomi , Yonezawa Sachiko , Matsunari Ichiro , Matsui Osamu , Ueda Fumiaki , Ryu Yasuji , Sakamoto Masanobu , Ouchi Yasuomi , Chita Madoka , Fujita Yumiko , Majima Rika , Tsubota Hiromi , Shirasawa Umeo , Sugimori Masashi , Ariya Wataru , Hagiwara Yuuzou , Tanizaki Yasuo , Fukuyama Hidenao , Takahashi Ryosuke , Takechi Hajime , Namiki Chihiro , Uemura Kengo , Kihara Takeshi , Yamauchi Hiroshi , Tanaka-Urayama Shizuko , Maeda Emiko , Saito Natsu , Satomi Shiho , Kabata Konomi , Urayama Shin-Ichi , Okada Tomohisa , Ishizu Koichi , Kawase Shigeto , Fukumoto Satoshi , Nakagawa Masanori , Tokuda Takahiko , Kondo Masaki , Niwa Fumitoshi , Mizuno Toshiki , Oishi Yoko , Yamazaki Mariko , Yamaguchi Daisuke , Ito Kyoko , Asano Yoku , Hamaguchi Chizuru , Yamada Kei , Okuyama Chio , Akazawa Kentaro , Matsushima Shigenori , Matsuo Takamasa , Nakagawa Toshiaki , Nii Takeshi , Nishida Takuji , Kiuchi Kuniaki , Fukusumi Masami , Watanabe Hideyuki , Taoka Toshiaki , Nogi Akihiro , Takeda Masatoshi , Tanaka Toshihisa , Sato Naoyuki , Kazui Hiroaki , Yoshiyama Kenji , Kudo Takashi , Okochi Masayasu , Morihara Takashi , Tagami Shinji , Hayashi Noriyuki , Takaya Masahiko , Wada Tamiki , Yokokoji Mikiko , Sugiyama Hiromichi , Yamamoto Daisuke , Takeda Shuko , Nomura Keiko , Tomioka Mutsumi , Uchida Eiichi , Ikeda Yoshiyuki , Murakami Mineto , Miki Takami , Shimada Hiroyuki , Ataka Suzuka , Kanemoto Motokatsu , Takeuchi Jun , Takeda Akitoshi , Azuma Rie , Iwamoto Yuki , Tagawa Naomi , Masao Junko , Matsumoto Yuka , Kikukawa Yuko , Fujii Hisako , Matsumura Junko , Shiomi Susumu , Kawabe Joji , Shimonishi Yoshihiro , Miki Yukio , Higashida Mitsuji , Sahara Tomohiro , Yamanaga Takashi , Sakamoto Shinichi , Tsushima Hiroyuki , Maeda Kiyoshi , Yamamoto Yasuji , Kawamata Toshio , Sakai Kazuo , Oda Haruhiko , Sakurai Takashi , Akisaki Taichi , Adachi Mizuho , Kuranaga Masako , Takegawa Sachi , Tahara Yoshihiko , Terada Seishi , Ishihara Takeshi , Honda Hajime , Yokota Osamu , Kishimoto Yuki , Takeda Naoya , Imai Nao , Yabe Mayumi , Ida Kentaro , Anami Daigo , Inoue Seiji , Matsushita Toshi , Wada Reiko , Hiramatsu Shinsuke , Tonbara Hiromi , Yamamoto Reiko , Nakashima Kenji , Wada-Isoe Kenji , Yamasaki Saori , Yamashita Eijiro , Nakamura Yu , Ishikawa Ichiro , Danjo Sonoko , Shinohara Tomomi , Ueno Miyuki , Kashimoto Yuka , Nishiyama Yoshihiro , Yamamoto Yuka , Kimura Narihide , Ogawa Kazuo , Sasakawa Yasuhiro , Ishimori Takashi , Maeda Yukito , Yamada Tatsuo , Ouma Shinji , Fukuhara-Kaneumi Aika , Sakamoto Nami , Nagao Rie , Yoshimitsu Kengo , Kuwabara Yasuo , Nakamuta Ryuji , Tanaka Minoru , Ikeda Manabu , Hashimoto Mamoru , Kaneda Keiichirou , Yatabe Yuusuke , Honda Kazuki , Ichimi Naoko , Akatuka Fumi , Morinaga Mariko , Noda Miyako , Kitajima Mika , Hirai Toshinori , Shiraishi Shinya , Amano Naoji , Washizuka Shinsuke , Takahashi Toru , Inuzuka Shin , Hagiwara Tetsuya , Sugiyama Nobuhiro , Okada Yatsuka , Ogihara Tomomi , Yasaki Takehiko , Kitayama Minori , Owa Tomonori , Ryokawa Akiko , Takeuchi Rie , Goto Satoe , Yamauchi Keiko , Ito Mie , Kaneko Tomoki , Ueda Hitoshi , Ikeda Shuichi , Takao Masaki , Mihara Ban , Kubo Hirofumi , Takano Akiko , Yasui Gou , Akuzawa Masami , Yamaguchi Kaori , Odawara Toshinari , Shimamura Megumi , Sugiyama Mikiko , Watanabe Atsushi , Oota Naomi , Takebayashi Shigeo , Hayakawa Yoshigazu , Idegawa Mitsuhiro , Toya Noriko , Ishii Kazunari , Kuwabara Satoshi 
Published: August 2023

We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer’s Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.