bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer’s Disease
Authors: Chen Yen-Ching , Hsiao Chi-Jung , Jung Chien-Cheng , Hu Hui-Han , Chen Jen-Hau , Lee Wen-Chung , Chiou Jeng-Min , Chen Ta-Fu , Sun Yu , Wen Li-Li , Yip Ping-Keung , Chu Yi-Min , Chen Chien-Jen , Yang Hwai-I
Published: November 2016

Previous genome-wide association studies using P-values to select single nucleotide polymorphisms (SNPs) have suffered from high false-positive and false-negative results. This case-control study recruited 713 late-onset Alzheimer’s disease (LOAD) cases and controls aged ≥65 from three teaching hospitals in northern Taiwan from 2007 to 2010. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics. After correction for multiple tests, no SNPs were identified by traditional P-values. Simultaneous testing of APOE e4 and APOC1 rs4420638 (the SNP with the best performance in the performance metrics) significantly improved the low sensitivity of APOE e4 from 0.50 to 0.78. A point-based genetic model including these 2 SNPs and important covariates was constructed. Compared with elders with low-risks score (0–6), elders belonging to moderate-risk (score = 7–11) and high-risk (score = 12–18) groups showed a significantly increased risk of LOAD (adjusted odds ratio = 7.80 and 46.93, respectively; Ptrend < 0.0001). Performance metrics allow for identification of markers with moderate effect and are useful for creating genetic tests with clinical and public health implications.
High-speed quantum networking by ship
Authors: Devitt Simon J. , Greentree Andrew D. , Stephens Ashley M. , Van Meter Rodney
Published: November 2016

Networked entanglement is an essential component for a plethora of quantum computation and communication protocols. Direct transmission of quantum signals over long distances is prevented by fibre attenuation and the no-cloning theorem, motivating the development of quantum repeaters, designed to purify entanglement, extending its range. Quantum repeaters have been demonstrated over short distances, but error-corrected, global repeater networks with high bandwidth require new technology. Here we show that error corrected quantum memories installed in cargo containers and carried by ship can provide a exible connection between local networks, enabling low-latency, high-fidelity quantum communication across global distances at higher bandwidths than previously proposed. With demonstrations of technology with sufficient fidelity to enable topological error-correction, implementation of the quantum memories is within reach, and bandwidth increases with improvements in fabrication. Our approach to quantum networking avoids technological restrictions of repeater deployment, providing an alternate path to a worldwide Quantum Internet.
Synthesis and Application of Ferroelectric Poly(Vinylidene Fluoride-co-Trifluoroethylene) Films using Electrophoretic Deposition
Authors: Ryu Jeongjae , No Kwangsoo , Kim Yeontae , Park Eugene , Hong Seungbum
Published: November 2016

In this study, we investigated the deposition kinetics of polyvinylidene fluoride copolymerized with trifluoroethylene (P(VDF-TrFE)) particles on stainless steel substrates during the electrophoretic deposition (EPD) process. The effect of applied voltage and deposition time on the structure and ferroelectric property of the P(VDF-TrFE) films was studied in detail. A method of repeated EPD and heat treatment above melting point were employed to fabricate crack-free P(VDF-TrFE) thick films. This method enabled us to fabricate P(VDF-TrFE) films with variable thicknesses. The morphology of the obtained films was investigated by scanning electron microscopy (SEM), and the formation of β-phase was confirmed by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. P(VDF-TrFE) films prepared with various thicknesses showed remnant polarization (Pr) of around 4 μC/cm2. To demonstrate the applicability of our processing recipe to complex structures, we fabricated a spring-type energy harvester by depositing P(VDF-TrFE) films on stainless steel springs using EPD process. Our preliminary results show that an electrophoretic deposition can be applied to produce high-quality P(VDF-TrFE) films on planar as well as three-dimensional (3-D) substrates.
CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells
Authors: Ruiz Paula , Martin-Millan Marta , Gonzalez-Martin M. C. , Almeida Maria , González-Macias Jesús , Ros Maria A.
Published: November 2016

It is well established that activation of Wnt/βcatenin signaling in the osteoblast lineage leads to an increase in bone mass through a dual mechanism: increased osteoblastogenesis and decreased osteoclastogenesis. However, the effect of this pathway on the osteoclast lineage has been less explored. Here, we aimed to examine the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1f/f;CtsKCre mice). These mice developed a severe low-bone-mass phenotype with onset in the second month and in correlation with an excessive number of osteoclasts, detected by TRAP staining and histomorphometric quantification. We found that WNT3A, through the canonical pathway, promoted osteoclast apoptosis and therefore attenuated the number of M-CSF and RANKL-derived osteoclasts in vitro. This reveals a cell-autonomous effect of Wnt/βcatenin signaling in controlling the life span of mature osteoclasts. Furthermore, bone Opg expression in Ctnnb1f/f;CtsKCre mice was dramatically decreased pointing to an additional external activation of osteoclasts. Accordingly, expression of CathepsinK was detected in TRAP-negative cells of the inner periosteal layer also expressing Col1. Our results indicate that the bone phenotype of Ctnnb1f/f;CtsKCre animals combines a cell-autonomous effect in the mature osteoclast with indirect effects due to the additional targeting of osteoblastic cells.
Colour formation on the wings of the butterfly Hypolimnas salmacis by scale stacking
Authors: Siddique Radwanul Hasan , Vignolini Silvia , Bartels Carolin , Wacker Irene , Hölscher Hendrik
Published: November 2016

The butterfly genusHypolimnasfeatures iridescent blue colouration in some areas of its dorsal wings. Here, we analyse the mechanisms responsible for such colouration on the dorsal wings ofHypolimnas salmacisand experimentally demonstrate that the lower thin lamina in the white cover scales causes the blue iridescence. This outcome contradicts other studies reporting that the radiant blue inHypolimnasbutterflies is caused by complex ridge-lamellar architectures in the upper lamina of the cover scales. Our comprehensive optical study supported by numerical calculation however shows that scale stacking primarily induces the observed colour appearance ofHypolimnas salmacis.
Coral symbioses under prolonged environmental change: living near tolerance range limits
Authors: Sampayo Eugenia M. , Ridgway Tyrone , Franceschinis Lorenzo , Roff George , Hoegh-Guldberg Ove , Dove Sophie
Published: November 2016

As climate change progresses, understanding the long-term response of corals and their endosymbionts (Symbiodinium) to prolonged environmental change is of immediate importance. Here, a total of 1152 fragments from 72 colonies of three common coral species (Stylophora pistillata, Pocillopora damicornis, Seriatopora hystrix) underwent a 32-month reciprocal depth transplantation. Genetic analysis showed that while S. hystrix maintained its generalist symbiont, some S. pistillata and P. damicornis underwent temporary changes in resident symbionts immediately after stress (transplantation; natural bleaching). These temporary changes were phylogenetically constrained to ‘host-compatible’ symbionts only and reversion to original symbionts occurred within 7 to 12 months, indicating long-term fidelity and stability of adult symbioses. Measurements of symbiont photo-physiology (dark adapted yield, pressure over photosystem II) and coral health (host protein, bleaching status, mortality) indicated a broad acclimatory capacity. However, this came at an apparent energetic expense as disproportionate mortality amongst symbioses that persisted outside their distribution range was observed following a natural bleaching event. As environmental changes due to climate change become more continuous in nature, sub-lethal effects linked to the existence near tolerance range limits coupled with the inability of adult coral colonies to change resident symbionts makes corals particularly susceptible to additional environmental fluctuations or stress events and reduces the resilience of coral populations.
Surface micro- and nano-texturing of stainless steel by femtosecond laser for the control of cell migration
Authors: Martínez-Calderon M. , Manso-Silván M. , Rodríguez A. , Gómez-Aranzadi M. , García-Ruiz J. P. , Olaizola S. M. , Martín-Palma R. J.
Published: November 2016

The precise control over the interaction between cells and the surface of materials plays a crucial role in optimizing the integration of implanted biomaterials. In this regard, material surface with controlled topographic features at the micro- and nano-scales has been proved to affect the overall cell behavior and therefore the final osseointegration of implants. Within this context, femtosecond (fs) laser micro/nano machining technology was used in this work to modify the surface structure of stainless steel aiming at controlling cell adhesion and migration. The experimental results show that cells tend to attach and preferentially align to the laser-induced nanopatterns oriented in a specific direction. Accordingly, the laser-based fabrication method here described constitutes a simple, clean, and scalable technique which allows a precise control of the surface nano-patterning process and, subsequently, enables the control of cell adhesion, migration, and polarization. Moreover, since our surface-patterning approach does not involve any chemical treatments and is performed in a single step process, it could in principle be applied to most metallic materials.
X-Ray based Lung Function measurement–a sensitive technique to quantify lung function in allergic airway inflammation mouse models
Authors: Dullin C. , Markus M. A. , Larsson E. , Tromba G. , Hülsmann S. , Alves F.
Published: November 2016

In mice, along with the assessment of eosinophils, lung function measurements, most commonly carried out by plethysmography, are essential to monitor the course of allergic airway inflammation, to examine therapy efficacy and to correlate animal with patient data. To date, plethysmography techniques either use intubation and/or restraining of the mice and are thus invasive, or are limited in their sensitivity. We present a novel unrestrained lung function method based on low-dose planar cinematic x-ray imaging (X-Ray Lung Function, XLF) and demonstrate its performance in monitoring OVA induced experimental allergic airway inflammation in mice and an improved assessment of the efficacy of the common treatment dexamethasone. We further show that XLF is more sensitive than unrestrained whole body plethysmography (UWBP) and that conventional broncho-alveolar lavage and histology provide only limited information of the efficacy of a treatment when compared to XLF. Our results highlight the fact that a multi-parametric imaging approach as delivered by XLF is needed to address the combined cellular, anatomical and functional effects that occur during the course of asthma and in response to therapy.
Experimental piscine alphavirus RNA recombination in vivo yields both viable virus and defective viral RNA
Authors: Petterson Elin , Guo Tz-Chun , Evensen Øystein , Mikalsen Aase B.
Published: November 2016

RNA recombination in non-segmented RNA viruses is important for viral evolution and documented for several virus species through in vitro studies. Here we confirm viral RNA recombination in vivo using an alphavirus, the SAV3 subtype of Salmon pancreas disease virus. The virus causes pancreas disease in Atlantic salmon and heavy losses in European salmonid aquaculture. Atlantic salmon were injected with a SAV3 6K-gene deleted cDNA plasmid, encoding a non-viable variant of SAV3, together with a helper cDNA plasmid encoding structural proteins and 6K only. Later, SAV3-specific RNA was detected and recombination of viral RNA was confirmed. Virus was grown from plasmid-injected fish and shown to infect and cause pathology in salmon. Subsequent cloning of PCR products confirming recombination, documented imprecise homologous recombination creating RNA deletion variants in fish injected with cDNA plasmid, corresponding with deletion variants previously found in SAV3 from the field. This is the first experimental documentation of alphavirus RNA recombination in an animal model and provides new insight into the production of defective virus RNA.
Identification of DNA primase inhibitors via a combined fragment-based and virtual screening
Authors: Ilic Stefan , Akabayov Sabine R. , Arthanari Haribabu , Wagner Gerhard , Richardson Charles C. , Akabayov Barak
Published: November 2016

The structural differences between bacterial and human primases render the former an excellent target for drug design. Here we describe a technique for selecting small molecule inhibitors of the activity of T7 DNA primase, an ideal model for bacterial primases due to their common structural and functional features. Using NMR screening, fragment molecules that bind T7 primase were identified and then exploited in virtual filtration to select larger molecules from the ZINC database. The molecules were docked to the primase active site using the available primase crystal structure and ranked based on their predicted binding energies to identify the best candidates for functional and structural investigations. Biochemical assays revealed that some of the molecules inhibit T7 primase-dependent DNA replication. The binding mechanism was delineated via NMR spectroscopy. Our approach, which combines fragment based and virtual screening, is rapid and cost effective and can be applied to other targets.
Large-scale identification of adverse drug reaction-related proteins through a random walk model
Authors: Chen Xiaowen , Shi Hongbo , Yang Feng , Yang Lei , Lv Yingli , Wang Shuyuan , Dai Enyu , Sun Dianjun , Jiang Wei
Published: November 2016

Adverse drug reactions (ADRs) are responsible for drug failure in clinical trials and affect life quality of patients. The identification of ADRs during the early phases of drug development is an important task. Therefore, predicting potential protein targets eliciting ADRs is essential for understanding the pathogenesis of ADRs. In this study, we proposed a computational algorithm,Integrated Network for Protein-ADR relations (INPADR), to infer potential protein-ADR relations based on an integrated network. First, the integrated network was constructed by connecting the protein-protein interaction network and the ADR similarity network using known protein-ADR relations. Then, candidate protein-ADR relations were further prioritized by performing a random walk with restart on this integrated network. Leave-one-out cross validation was used to evaluate the ability of the INPADR. An AUC of 0.8486 was obtained, which was a significant improvement compared to previous methods. We also applied the INPADR to two ADRs to evaluate its accuracy. The results suggested that the INPADR is capable of finding novel protein-ADR relations. This study provides new insight to our understanding of ADRs. The predicted ADR-related proteins will provide a reference for preclinical safety pharmacology studies and facilitate the identification of ADRs during the early phases of drug development.
Possible flat band bending of the Bi1.5Sb0.5Te1.7Se1.3 crystal cleaved in an ambient air probed by terahertz emission spectroscopy
Authors: Park Soon Hee , Hamh Sun Young , Park Joonbum , Kim Jun Sung , Lee Jong Seok
Published: November 2016

We investigate an evolution of the surface electronic state of the Bi1.5Sb0.5Te1.7Se1.3 single crystal, which is one of the most bulk insulating topological insulators, by examining terahertz light emitted from the sample surface upon the illumination of the near-infrared femtosecond laser pulses. We find that the surface state with a flat band bending can appear in the course of the natural maturation process of the surface state in an ambient air. Furthermore, we demonstrate that the evolution of the surface electronic state can be accelerated, decelerated, or even stopped by controlling environmental conditions to contain different amount of H2O, in particular.
Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems
Authors: Sengupta Dola , Kar Sandip
Published: November 2016

Bone morphogenetic protein 2 (BMP2), differentially regulates the developmental lineage commitment of neural stem cells (NSC’s) in central and peripheral nervous systems. However, the precise mechanism beneath such observations still remains illusive. To decipher the intricacies of this mechanism, we propose a generic mathematical model of BMP2 driven differentiation regulation of NSC’s. The model efficiently captures the dynamics of the wild-type as well as various mutant and over-expression phenotypes for NSC’s in central nervous system. Our model predicts that the differential developmental dynamics of the NSC’s in peripheral nervous system can be reconciled by altering the relative positions of the two mutually interconnected bi-unstable switches inherently present in the steady state dynamics of the crucial developmental fate regulatory proteins as a function of BMP2 dose. This model thus provides a novel mechanistic insight and has the potential to deliver exciting therapeutic strategies for neuronal regeneration from NSC’s of different origin.
A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes
Authors: Allhorn Maria , Arve Sabine , Brüggemann Holger , Lood Rolf
Published: November 2016

The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes’ survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.
Shell properties of commercial clam Chamelea gallina are influenced by temperature and solar radiation along a wide latitudinal gradient
Authors: Gizzi Francesca , Caccia Maria Giulia , Simoncini Ginevra Allegra , Mancuso Arianna , Reggi Michela , Fermani Simona , Brizi Leonardo , Fantazzini Paola , Stagioni Marco , Falini Giuseppe , Piccinetti Corrado , Goffredo Stefano
Published: November 2016

Phenotype can express different morphologies in response to biotic or abiotic environmental influences. Mollusks are particularly sensitive to different environmental parameters, showing macroscale shell morphology variations in response to environmental parameters. Few studies concern shell variations at the different scale levels along environmental gradients. Here, we investigate shell features at the macro, micro and nanoscale, in populations of the commercially important clamChamelea gallinaalong a latitudinal gradient (~400 km) of temperature and solar radiation in the Adriatic Sea (Italian cost). Six populations of clams with shells of the same length were analyzed. Shells from the warmest and the most irradiated population were thinner, with more oval shape, more porous and lighter, showing lower load fracture. However, no variation was observed in shell CaCO3polymorphism (100% aragonite) or in compositional and textural shell parameters, indicating no effect of the environmental parameters on the basic processes of biomineralization. Because of the importance of this species as commercial resource in the Adriatic Sea, the experimentally quantified and significant variations of mass and fracture load inC. gallinashells along the latitudinal gradient may have economic implications for fisheries producing different economical yield for fishermen and consumers along the Adriatic coastline.
Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes
Authors: Ren Yanfeng , Jin Nan , Hong Tianpei , Mu Yiming , Guo Lixin , Ji Qiuhe , Li Qiang , Yang Xilin , Ji Linong
Published: November 2016

Serum uric acid (SUA) at high levels and bilirubin at low levels were potent antioxidant but it was uncertain that whether SUA and total bilirubin (TBIL) had additive interaction for the risk of CVD in type 2 diabetes mellitus (T2DM). We conducted a cross-sectional survey of 6713 inpatients with T2DM and admitted to 81 tertiary care hospitals. CVD was defined as having either prior coronary heart disease or stroke or peripheral arterial disease. Binary logistic regression was used to estimate odds ratios of SUA and TBIL for CVD. The effect size of additive interaction was estimated by three measures, i.e., relative excess risk due to interaction, attributable proportion due to interaction and synergy index. Among 6713 patients with T2DM, 561 (8.36%) suffered from CVD. Using ≥283 umol/L (median) to define high SUA and <11.5 umol/L (n = 2290 or 34.11%) to define low TBIL, copresence of both factors (n = 621 or 9.25%) was associated with 5.18-fold (95% CI, 4.00–6.72) risk of CVD with significant additive interactions in multivariable analysis as compared to absence of both risk factors. The copresence of both high SUA and low TBIL was associated with a large increased risk of CVD in high-risk Chinese patients with type 2 diabetes.
Polymer-mediated ternary supramolecular interactions for sensitive detection of peptides
Authors: Serrano Mahalia A. C. , He Huan , Zhao Bo , Ramireddy Rajasekhar R. , Vachet Richard W. , Thayumanavan S.
Published: November 2016

A combination of donor–acceptor and electrostatic interactions in a three-component supramolecular system has been shown to form the basis for selective and sensitive detection of peptides.
Development and validation of an UHPLC-MS/MS method for the simultaneous determination of four flavonoid glycosides and phellopterin in rat plasma: application to a pharmacokinetic study of oral administration of Poncirus trifoliata extract
Authors: Wang Zhe , Qin Baoli
Published: November 2016

An UHPLC-MS/MS method was established and validated for the simultaneous determination of HE, NE, HMC, PO, and PH in rat plasma.
The use of vibrational spectroscopy techniques as a tool for the discrimination and identification of the natural and synthetic organic compounds used in conservation
Authors: Casanova Emmanuelle , Pelé-Meziani Charlène , Guilminot Élodie , Mevellec Jean-Yves , Riquier-Bouclet Christine , Vinçotte Armand , Lemoine Gwenaël
Published: November 2016

The flowchart is an efficient tool to help conservators to identify a sample by means of a ‘simplified’ discrimination method.
Simultaneous determination of Pb and Cd in low-cost jewelry using differential pulse voltammetry
Authors: Ferreira Taimara Polidoro , de Sousa Rafael Arromba , Lowinsohn Denise
Published: November 2016

The simultaneous electrochemical determination of lead (Pb) and cadmium (Cd) in low-cost jewelry was achieved using differential pulse voltammetry (DPV).
Interfacial gas nanobubbles or oil nanodroplets?
Authors: Wang Xingya , Zhao Binyu , Hu Jun , Wang Shuo , Tai Renzhong , Gao Xingyu , Zhang Lijuan
Published: November 2016

The force curves on nanobubbles and PDMS nanodroplets are quite different. The peculiar plateaus on nanobubbles can be used to distinguish these two easily confusing objects.
Interplay between surface and surface resonance states on height selective stability of fcc Dy(111) film at nanoscale
Authors: Liu Xiaojie , Wang Cai-Zhuang , Hupalo Myron , Ho Kai-Ming , Thiel Patricia A. , Tringides Michael C.
Published: November 2016

Ultrathin Dy film exhibits height-selective stability which can be attributed to the interplay between the localized surface states and surface resonance states due to electron confinement effects at nanoscale.
Water modulates the ultraslow dynamics of hydrated ionic liquids near CG rich DNA: consequences for DNA stability
Authors: Saha Debasis , Kulkarni Mandar , Mukherjee Arnab
Published: November 2016

The higher affinity of water towards CG-base pairs can alter the dynamics of ionic liquids in solution, causing entropic adversity in binding to the base pairs.
Site-projected electronic structure of two-dimensional Ti3C2MXene: the role of the surface functionalization groups
Authors: Magne Damien , Mauchamp Vincent , Célérier Stéphane , Chartier Patrick , Cabioc'h Thierry
Published: November 2016

The role of the surface groups in chemical bonding in two dimensional Ti3C2is evidenced at the nano-object level.
Band alignment and depletion zone at ZnO/CdS and ZnO/CdSe hetero-structures for temperature independent ammonia vapor sensing
Authors: Rajeswari Yogamalar N. , Sadhanandham K. , Chandra Bose A. , Jayavel R.
Published: November 2016

The excitation of CdS nanoparticles and the narrowing of depletion zone formed between the ZnO and CdS hetero-structures determine the sensing of ammonia vapor.
Reaction environment and ligand lability in group 4 Cp2MXY (X, Y = Cl, OtBu) complexes
Authors: Boyde Nicholas C. , Rightmire Nicholas R. , Bierschenk Eric J. , Steelman Grant W. , Hanusa Timothy P. , Brennessel William W.
Published: November 2016

Ligand transfer during halide metathesis with group 4 metallocenes depends on whether a polar solvent is used or not.
A stable europium metal–organic framework as a dual-functional luminescent sensor for quantitatively detecting temperature and humidity
Authors: Wang Dongbo , Tan Qinghua , Liu Jingjuan , Liu Zhiliang
Published: November 2016

A dual-functional Eu-MOF sensor for quantitatively detecting temperature and humidity.
Electronic and nuclear contributions to time-resolved optical and X-ray absorption spectra of hematite and insights into photoelectrochemical performance
Authors: Hayes Dugan , Hadt Ryan G. , Emery Jonathan D. , Cordones Amy A. , Martinson Alex B. F. , Shelby Megan L. , Fransted Kelly A. , Dahlberg Peter D. , Hong Jiyun , Zhang Xiaoyi , Kong Qingyu , Schoenlein Robert W. , Chen Lin X.
Published: November 2016

Spectra show both transient photocarriers and lattice heating.
Speciation of gold nanoparticles and low-molecular gold species in Wistar rat tissues by HPLC coupled to ICP-MS
Authors: Soto-Alvaredo Juan , López-Chaves Carlos , Sánchez-González Cristina , Montes-Bayón María , Llopis Juan , Bettmer Jörg
Published: November 2016

This work aims to address simultaneously the presence of gold nanoparticles and gold ionic species in biological samples by HPLC-ICP-MS.
Synthesis and ring-opening polymerization of 2-substituted 1,3-benzoxazine: the first observation of the polymerization of oxazine ring-substituted benzoxazines
Authors: Ohashi Seishi , Cassidy Francis , Huang Stephanie , Chiou Kevin , Ishida Hatsuo
Published: November 2016

2-Substituted 1,3-benzoxazines having a phenyl group as an oxazine ring substituent are synthesized with benzaldehyde through 2-hydroxy-N-phenylbenzylamine structures.
Magnetically separable graphene oxide anchored sulfonic acid: a novel, highly efficient and recyclable catalyst for one-pot synthesis of 3,6-di(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in deep eutectic solvent under microwave irradiation
Authors: Zhang Mo , Liu Peng , Liu Yu-Heng , Shang Ze-Ren , Hu Hai-Chuan , Zhang Zhan-Hui
Published: November 2016

A magnetic separable sulfonic acid catalyst was prepared and applied for the synthesis of 3,6-di(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles via three-component reaction of 1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-5-amine, β-ketonitrile and aldehydes in DES.
Largely-increased length of silver nanowires by controlled oxidative etching processes in solvothermal reaction and the application in highly transparent and conductive networks
Authors: Xu Xiaomei , He Song , Zhou Conghua , Xia Xingda , Xu Liao , Chen Hui , Yang Bingchu , Yang Junliang
Published: November 2016

Silver nanowire length was prolonged by a controlled oxidative etching process and the efficient ratio of the conductive routes was increased by the length.
Antifungal study of substituted 4-pyridylmethylene-4′-aniline Schiff bases
Authors: Lam P.-L. , Lee K. K.-H. , Kok S. H.-L. , Gambari R. , Lam K.-H. , Ho C.-L. , Ma X. , Lo Y.-H. , Wong W.-Y. , Dong Q.-C. , Bian Z.-X. , Chui C.-H.
Published: November 2016

Two substituted 4-pyridylmethylene-4′-aniline Schiff bases showed antifungal activity against.Aspergillus nigerandCandida albicans. They may be useful for the development of safe drug candidates forA. nigerandC. albicanscases of otomycosis.
Structural and light coupling characteristics of patterned silica–titania sol–gel thin films with/without nano gold coatings
Authors: Sarkar Saswati , Chattopadhyay Rik , Jana Sunirmal
Published: November 2016

Soft lithography-based 1-dimensional/2-dimensional patterned silica–titania sol–gel thin films with/without nano-Au coatings and their light coupling characteristics.
Cooperative halogen bonds in V-shaped H3N·X1X2·X3Y (X1, X2, X3 = Cl and Br; Y = F, Cl and Br) complexes
Authors: Yang Xing , Yan Chao-Xian , Zhou Da-Gang , Yang Fan , Zhou Pan-Pan
Published: November 2016

The dihalogen molecule can simultaneously interact with NH3 and another dihalogen molecule, forming a V-shaped trimer via cooperative halogen bonds.
Screening PEGylated polyethylenimine derivatives for safe and efficient delivery of gene materials
Authors: Tang Xuelan , Lu Ping , Qiu Mingfeng , Chen Jianjun , Ma Lin , Sun Yanan , Zheng Feng , Xu Enge , Sheng Jing , Su Jing
Published: November 2016

PEG–Et 1 : 1 was screened out for the safe and efficient gene delivery by precise design of PEGylated polymeric nanomaterials.
Carbon nanotube reinforced flexible multifunctional regenerated cellulose films for nonlinear optical application
Authors: Raghunathan Sreejesh Poikavila , Narayanan Sona , Joseph Rani
Published: November 2016

Carbon nanotube reinforced flexible multifunctional regenerated cellulose films for nonlinear optical application.
Low-temperature selective catalytic reduction of NO with NH3 over Ni–Mn–Ox catalysts
Authors: Zhang Peipei , Sun Yan , Su Wei , Wei Yajuan , Liu Jia
Published: November 2016

A series of Ni(n)–MnOx catalysts with high activity for the low temperature NH3-SCR have been synthesized by a hard template method.
A series of organic–inorganic hybrid materials consisting of flexible organic amine modified polyoxomolybdates: synthesis, structures and properties
Authors: Gong Chunhua , Zeng Xianghua , Zhu Chengfeng , Shu Jiahui , Xiao Pingxiu , Xu Hao , Liu Lichun , Zhang Junyong , Zeng Qingdao , Xie Jingli
Published: November 2016

A series of hybrid materials consisting of Tris[(2-pyridyl)methyl]amine modified polyoxomolybdates were obtained and some complexes have efficient photocatalytic activities to degrade pararosaniline hydrochloride dye molecules.
Solvent-free thermocuring electrospinning to fabricate ultrathin polyurethane fibers with high conductivity by in situ polymerization of polyaniline
Authors: He Hong-Wei , Zhang Bin , Yan Xu , Dong Rui-Hua , Jia Xian-Sheng , Yu Gui-Feng , Ning Xin , Xia Lin-Hua , Long Yun-Ze
Published: November 2016

Solidification mechanism of PU microfibers fabricated by solvent-free e-spinning under thermal radiation.
Synthesis of 2-arylated thiadiazolopyrimidones by Suzuki–Miyaura cross-coupling: a new class of nucleotide pyrophosphatase (NPPs) inhibitors
Authors: Jafari Behzad , Yelibayeva Nazym , Ospanov Meirambek , Ejaz Syeda Abida , Afzal Saira , Khan Shafi Ullah , Abilov Zharylkasyn A. , Turmukhanova Mirgul Z. , Kalugin Sergey N. , Safarov Sayfidin , Lecka Joanna , Sévigny Jean , Rahman Qamar , Ehlers Peter , Iqbal Jamshed , Langer Peter
Published: November 2016

Over expression of nucleotide pyrophosphatase (NPPs) activity is associated with chondrocalcinosis, osteoarthritis, type 2 diabetes, neurodegenerative diseases, allergies and cancer metastasis.
Piezo-resistive and thermo-resistance effects of highly-aligned CNT based macrostructures
Authors: Dau V. T. , Tran C. D. , Bui T. T. , Nguyen V. D. X. , Dinh T. X.
Published: November 2016

Recent advances in assembling Carbon NanoTubes (CNTs) into macrostructures with outstanding properties, such as high tensile strength, high conductivity and porosity, and strong corrosive resistance, have underpinned potentially novel applications.
Reduction mechanism of iron titanium based oxygen carriers with H2for chemical looping applications – a combined experimental and theoretical study
Authors: Liu Yu-Cheng , Nachimuthu Santhanamoorthi , Chuang Yu-Cheng , Ku Young , Jiang Jyh-Chiang
Published: November 2016

The role of iron titanium oxides in the reduction reactions for the CLP is investigated through experimental and theoretical methods. The experimentally predicated activation energies are in good agreement with theoretical values.
Chlorination of florfenicol (FF): reaction kinetics, influencing factors and by-products formation
Authors: Zhang Yansen , Shao Yisheng , Gao Naiyun , Chu Wenhai , Chen Juxiang , Li Shuo , Wang Yue , Xu Shuaixian
Published: November 2016

Florfenicol (FF) is a widely used antibiotic, which is commonly found in natural waters.
Theoretical study of copper complexes with lipoic and dihydrolipoic acids
Authors: Castañeda-Arriaga Romina , Alvarez-Idaboy J. Raul , Mora-Diez Nelaine
Published: November 2016

A Cu(ii) complex with doubly-deprotonated dihydrolipoic acid has antioxidant capacity, since it is able to slow down by two orders the first step of the Haber–Weiss cycle reducing the potential damage caused by ˙OH radical formation.
A review of mechanisms for fluorescent ‘‘turn-on’’ probes to detect Al3+ ions
Authors: Gupta Ankush , Kumar Naresh
Published: November 2016

The adverse effect of Al3+ ions on human health as well as the environment makes it desirable to develop sensitive and specific techniques for the detection of Al3+ ions.
Novel incorporation of mesoporous NiCo2O4 into thermoplastic polyurethane for enhancing its fire safety
Authors: Wang Junling , Yuan Bihe , Mu Xiaowei , Wang Wei , Hu Weizhao , Hu Yuan
Published: November 2016

During the combustion of TPU, the release of HCN was inhibited after the incorporation of mesoporous NiCo2O4 particles.
Gold nanoparticles supported on nanoscale amine-functionalized MIL-101(Cr) as a highly active catalyst for epoxidation of styrene
Authors: Saikia Mrinal , Kaichev Vasily , Saikia Lakshi
Published: November 2016

Gold nanoparticles can effectively be incorporated on to the matrix of NH2-MIL-101(Cr) by a facile solution approach. The resulting nanocatalyst acts as efficient heterogeneous catalyst for epoxidation of styrene.
Electric field makes Leidenfrost droplets take a leap
Authors: Wildeman Sander , Sun Chao
Published: November 2016

In a strong vertical electric field Leidenfrost droplets can start to bounce progressively higher, defying gravitational attraction.
K8Nb7P7O39: a new type of complicated incommensurately modulated structure and photoluminescence properties of Eu3+-doped solid solutions
Authors: Zhao Dan , Cui Jun-Yan , Han Hong-Xian , Li Can
Published: November 2016

A new type of potassium niobium phosphate, K8Nb7P7O39, has been prepared and its (3 + 1)-dimensional incommensurately modulated structure has been modeled.
Enhanced electrochromic performance of WO3 nanowire networks grown directly on fluorine-doped tin oxide substrates
Authors: Li Yiqun , Chen Dehong , Caruso Rachel A.
Published: November 2016

A WO3 nanowire film was prepared directly on conducting glass and showed good electrochromic properties.
An erasable photo-patterning material based on a specially designed 4-(1,2,2-triphenylvinyl)aniline salicylaldehyde hydrazone aggregation-induced emission (AIE) molecule
Authors: Wang Lili , Li Yuanyuan , You Xuejiao , Xu Kui , Feng Qi , Wang Jinmin , Liu Yuanyuan , Li Kai , Hou Hongwei
Published: November 2016

An aggregation-induced emission (AIE) molecule with reversible photochromic properties which can be served as a material for photo-patterning with erasable properties.
Flexible and highly fluorescent aromatic polyimide: design, synthesis, properties, and mechanism
Authors: Zhou Zhuxin , Zhang Yi , Liu Siwei , Chi Zhenguo , Chen Xudong , Xu Jiarui
Published: November 2016

A flexible and highly fluorescent aromatic polyimide can be obtained by appropriate control of the intra-molecular charge-transfer effects between the diamine and dianhydride moieties.
Near-infrared long persistent luminescence of Er3+ in garnet for the third bio-imaging window
Authors: Xu Jian , Murata Daisuke , Ueda Jumpei , Tanabe Setsuhisa
Published: November 2016

By utilizing efficient persistent energy transfer from Ce3+ to Er3+, we have successfully developed a novel garnet persistent phosphor of Y3Al2Ga3O12 doped with Er3+, Ce3+, Cr3+ ions (YAGG:Er–Ce–Cr) exhibiting long (>10 h) near-infrared (NIR) persistent luminescence (PersL) in the broad range from 1450 nm to 1670 nm due to the typical Er3+:4I13/2 → 4I15/2 transition in garnet.
The electronic transport properties of transition-metal dichalcogenide lateral heterojunctions
Authors: An Yipeng , Zhang Mengjun , Wu Dapeng , Fu Zhaoming , Wang Kun
Published: November 2016

All kinds of MoS2–WS2 lateral heterojunctions present an interesting negative differential resistive effect.
A DEHP plasticizer alters synaptic proteins via peroxidation
Authors: Wang Shaohui , Zhang Pengyan , Liu Ruifang , Li Yuan , Liu Chao , Liao Xiaomei
Published: November 2016

Di-(2-ethylhexyl) phthalate (DEHP) is a widely used commercial plasticizer.
Dimerization of the plant molybdenum insertase Cnx1E is required for synthesis of the molybdenum cofactor
Authors: Krausze Joern , Probst Corinna , Curth Ute , Reichelt Joachim , Saha Sayantan , Schafflick David , Heinz Dirk W. , Mendel Ralf R. , Kruse Tobias
Published: November 2016

The molybdenum cofactor (Moco) is a redox active prosthetic group, essentially required for numerous enzyme-catalyzed two electron transfer reactions. Moco is synthesized by an evolutionarily old and highly conserved multistep pathway. In the last step of Moco biosynthesis, the molybdenum center is inserted into the final Moco precursor adenylated molybdopterin (MPT-AMP). This unique and yet poorly characterized maturation reaction finally yields physiologically active Moco. In the model plant Arabidopsis, the two domain enzyme, Cnx1, is required for Moco formation. Recently, a genetic screen identified novel Arabidopsis cnx1 mutant plant lines each harboring a single amino acid exchange in the N-terminal Cnx1E domain. Biochemical characterization of the respective recombinant Cnx1E variants revealed two different amino acid exchanges (S197F and G175D) that impair Cnx1E dimerization, thus linking Cnx1E oligomerization to Cnx1 functionality. Analysis of the Cnx1E structure identified Cnx1E active site-bound molybdate and magnesium ions, which allowed to fine-map the Cnx1E MPT-AMP-binding site.
Wavelet‐alienation based transmission line protection scheme
Authors: Rathore Bhuvnesh , Shaik Abdul Gafoor
Published: November 2016

This study presents a wavelet‐alienation based algorithm for protection of two terminal transmission line. The proposed algorithm makes use of wavelet transform based approximate coefficients of three‐phase voltage and current signals, obtained over a quarter cycle to detect, classify and locate various faults. Detection and classification of these faults are achieved with the help of alienation coefficients of current signals from both the terminals of the transmission line. The approximate coefficients of voltage and current signals, obtained over a quarter cycle, are fed to artificial neural network to locate the faults precisely. The proposed algorithm has been tested successfully for various types of faults with the variations in location, inception angle and fault impedance.
Impact of crystalline damage on a vertically integrated junctionless nanowire transistor
Authors: Ahn Dae-Chul , Lee Byung-Hyun , Kang Min-Ho , Hur Jae , Bang Tewook , Choi Yang-Kyu
Published: November 2016

The influence of process-induced defect formation was investigated in a vertically integrated (VI) junctionless-mode field-effect transistor (JL-FET). Compared to the low energy and one-time ion-implantation process to fabricate a single nanowire-based FET, the high-energy and repetitive ion-implantation process for the creation of the VI JL-FET inevitably generates more defects in the crystalline sites. Even after high-temperature rapid thermal annealing, the non-recovered defect sites existing in the interface and silicon channel, as verified by a transmission electron microscopy analysis, lead to the degradation of the electrical performance such as on- and off-state current. Particularly, the abnormal behavior of the off-state current, mostly arising from the gate-induced drain leakage, was analyzed using the experimental results, and supported by the numerical simulation as well.
Spatial distribution of superconducting and charge-density-wave order parameters in cuprates and its influence on the quasiparticle tunnel current (Review Article)
Authors: Gabovich Alexander M. , Voitenko Alexander I.
Published: November 2016

The state of the art concerning tunnel measurements of energy gaps in cuprate oxides has been analyzed. A detailed review of the relevant literature is made, and original results calculated for the quasiparticle tunnel current J(V) between a metallic tip and a disordered d-wave superconductor partially gapped by charge density waves (CDWs) are reported, because it is this model of high-temperature superconductors that becomes popular owing to recent experiments in which CDWs were observed directly. The current was calculated suggesting the scatter of both the superconducting and CDW order parameters due to the samples' intrinsic inhomogeneity. It was shown that peculiarities in the current-voltage characteristics inherent to the case of homogeneous superconducting material are severely smeared, and the CDW-related features transform into experimentally observed peak-dip-hump structures. Theoretical results were used to fit data measured for YBa2Cu3O7–δ and Bi2Sr2CaCu2O8+δ. The fitting demonstrated a good qualitative agreement between the experiment and model calculations. The analysis of the energy gaps in high-Tc superconductors is important both per se and as a tool to uncover the nature of superconductivity in cuprates not elucidated so far despite of much theoretical effort and experimental progress.
Electronic structure of FeSe monolayer superconductors
Authors: Nekrasov I. A. , Pavlov N. S. , Sadovskii M. V. , Slobodchikov A. A.
Published: November 2016

We review a variety of theoretical and experimental results concerning electronic band structure of superconducting materials based on FeSe monolayers. Three type of systems are analyzed: intercalated FeSe systems AxFe2Se2–xSx and [Li1–xFexOH]FeSe as well as the single FeSe layer films on SrTiO3 substrate. We present the results of detailed first principle electronic band structure calculations for these systems together with comparison with some experimental ARPES data. The electronic structure of these systems is rather different from that of typical FeAs superconductors, which is quite significant for possible microscopic mechanism of superconductivity. This is reflected in the absence of hole pockets of the Fermi surface at T-point in Brillouin zone, so that there are no “nesting” properties of different Fermi surface pockets. LDA + DMFT calculations show that correlation effects on Fe-3d states in the single FeSe layer are not that strong as in most of FeAs systems. As a result, at present there is no theoretical understanding of the formation of rather “shallow” electronic bands at M-points. LDA calculations show that the main difference in electronic structure of FeSe monolayer on SrTiO3 substrate from isolated FeSe layer is the presence of the band of O-2p surface states of TiO2 layer on the Fermi level together with Fe-3d states, which may be important for understanding the enhanced Tc values in this system. We briefly discuss the implications of our results for microscopic models of superconductivity.
Impact of surface orientation on (100), (111)A, and (111)B InGaAs surfaces with In content of 0.53 and 0.70 and on their Al2O3/InGaAs metal-oxide-semiconductor interface properties
Authors: Yokoyama Masafumi , Suzuki Rena , Taoka Noriyuki , Takenaka Mitsuru , Takagi Shinichi
Published: November 2016

We have studied the impact of surface orientation on the (100), (111)A, and (111)B InGaAs surfaces with the In content of 0.53 and 0.70 and on their Al2O3/InGaAs meta-oxide-semiconductor interface properties using NH4OH and (NH4)2Sx solutions. The (111)A and (111)B surfaces with NH4OH cleaning can achieve good interface properties as similar to (100) surfaces, while the (111)A surfaces with (NH4)2Sx cleaning can achieve better interface properties than (100) and (111)B surfaces.
Theory based scaling of edge turbulence and implications for the scrape-off layer width
Authors: Myra J. R. , Russell D. A. , Zweben S. J.
Published: November 2016

Turbulence and plasma parameter data from the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40, 557 (2000)] is examined and interpreted based on various theoretical estimates. In particular, quantities of interest for assessing the role of turbulent transport on the midplane scrape-off layer heat flux width are assessed. Because most turbulence quantities exhibit large scatter and little scaling within a given operation mode, this paper focuses on length and time scales and dimensionless parameters between operational modes including Ohmic, low (L), and high (H) modes using a large NSTX edge turbulence database [Zweben et al., Nucl. Fusion 55, 093035 (2015)]. These are compared with theoretical estimates for drift and interchange rates, profile modification saturation levels, a resistive ballooning condition, and dimensionless parameters characterizing L and H mode conditions. It is argued that the underlying instability physics governing edge turbulence in different operational modes is, in fact, similar, and is consistent with curvature-driven drift ballooning. Saturation physics, however, is dependent on the operational mode. Five dimensionless parameters for drift-interchange turbulence are obtained and employed to assess the importance of turbulence in setting the scrape-off layer heat flux width λq and its scaling. An explicit proportionality of the width λq to the safety factor and major radius (qR) is obtained under these conditions. Quantitative estimates and reduced model numerical simulations suggest that the turbulence mechanism is not negligible in determining λq in NSTX, at least for high plasma current discharges.