bluuebunny/crossref_metadata_2025 huggingface dataset:
Páll Björnsson, Jón forseti allur? Táknmyndir þjóðhetju frá andláti til samtíðar (Reykjavík: Sögufélag, 2011)
Authors: Jónsson Þorlákur Axel
Published: August 2020

The book Páll Björnsson has written entitled President Jón in Full? Icons of a National Hero From His Death to the Present, deprives the Icelandic people of the icon of president Jón Sigurðsson (1811-1879) qua omnipotent father of the nation. This is done elegantly.
Treatment of muscle‐invasive and advanced bladder cancer in 2020
Authors: Patel Vaibhav G. , Oh William K. , Galsky Matthew D.
Published: August 2020

Bladder cancer accounts for nearly 170,000 deaths worldwide annually. For over 4 decades, the systemic management of muscle‐invasive and advanced bladder cancer has primarily consisted of platinum‐based chemotherapy. Over the past 10 years, innovations in sequencing technologies have led to rapid genomic characterization of bladder cancer, deepening our understanding of bladder cancer pathogenesis and exposing potential therapeutic vulnerabilities. On the basis of its high mutational burden, immune checkpoint inhibitors were investigated in advanced bladder cancer, revealing durable responses in a subset of patients. These agents are now approved for several indications and highlight the changing treatment landscape of advanced bladder cancer. In addition, commonly expressed molecular targets were leveraged to develop targeted therapies, such as fibroblast growth factor receptor inhibitors and antibody‐drug conjugates. The molecular characterization of bladder cancer and the development of novel therapies also have stimulated investigations into optimizing treatment approaches for muscle‐invasive bladder cancer. Herein, the authors review the history of muscle‐invasive and advanced bladder cancer management, highlight the important molecular characteristics of bladder cancer, describe the major advances in treatment, and offer future directions for therapeutic development.
The biological and technological aspects of obtaining the geleeroyale
Authors: Mishchenko O. , Lytvynenko O. , Kryvoruchko D. , Ischenko Y.
Published: August 2020

In presented work there is given data of experimental researches of infl uence of queen-rearing colony on larval bees adoption and infl uence of diff erent technological elements on larval bees adoption and obtaining of honeybee geleeroyale. The aim of the work is optimization of technological processes of geleeroyaleobtaining and researching of their infl uence on larval bees adoption and production of geleeroyale. It was tasked to explore diff erent ways of obtaining geleeroyaleand to choose the most optimal one for industrial apiary conditions. There were compared some ways of complete and incomplete orphanage of bee families. The method of incomplete (partial) orphanage of bee family means that queen bee wasn’t completely isolated from bee family, and complete orphanage means that queen bees were excluded. Analyzing the biological mechanism of incomplete orphanage method where bees also adopt larvae for rearing and produce geleeroyale, it is possible to suspect that only a part of bees feel the presence of queen. Only year-long beesfeel the presence of queen because they are the ones who penetrate through the diaphragm section with built-in block of queen excluder and provide bee family with nectar and protein food. Another part of bees (nurse bees) which don’t have access behind the diaphragm, where queen bee works, feel its absence and intensively feed up larvae on grafting frames producing geleeroyale. Using the Nicot system it is observed the highest larvae adoption and the biggest mass of obtained geleeroyalecompared with other technological elements We need to choose the methods of bee family formation in order to getgeleeroyale depending on season period, specifi c conditions, tasks and production volume. For more simplifi ed technology of geleeroyaleobtaining it is recommended to use Nicot system.
Key words: bee family, nurse colony, larva, geleeroyale, queen-cell cumulosol, Nicot system, complete orphanage, partial orphanage of bee family.
Fasting Blood Glucose Test in Nepal - Time for a Harmonized Definition
Authors: Pant Vivek , Gautam Keyoor , Pradhan Santosh
Published: August 2020

There are various views in defining protocols for fasting blood glucose test currently being used by healthcare providers in Nepal. A number of modifiable factors can influence the result of an estimation of fasting blood glucose in a clinical laboratory. Variations in the results of fasting blood glucose tests are usually controlled by minimizing the discrepancies in the pretesting variables, one of which is the inconsistency in what represents fasting. In order to minimize the complications of erroneous reporting of fasting blood sugar tests, it is crucial to define the protocols for the test and adopt them in unison by all clinical laboratories of Nepal. Keywords: Clinical laboratory; fasting blood glucose; pretesting variables.
Effects of Disaster on Primary Health Care in Low Income Countries
Authors: Ray Kirti , Ghimire Jagadishwor , BC Rajendra Kumar
Published: August 2020

Primary health care is considered to be a practical approach to provide basic curative, preventive and promotive health care as an accessible medium for the people particularly in low resource income countries in an affordable way. This paper reviewed that an integrated primary health care system could reduce fundamental vulnerability of disasters; thereafter protect the health facilities and services for providing health programs. Further it focused on the increased uptake on health services to build resilience among individuals of low resource countries having high exposure to disasters. It also provides an idea on the practices adapted for gaining resilience of primary health care of low resource regions like Africa, South and South East Asia which are frequently exposed to disasters. However, this study did not focus on the health governance, pre-hospital disaster management and funding policies which are limited at present in low income countries affected by frequent disasters.Keywords: Disasters; disaster management; low income countries; primary health care; resilience.
Työnohjaus ihmissuhdeammateissa oppimisprosessina
Authors: Sandelin Singa
Published: August 2020

Artikkelissa tarkastellaan klassisen työnohjauksen (supervision) käsitettä ja sisältöä ammatillisen identiteetin kasvun välineenä. Työnohjauksen leviäminen muillekin kuin hoitotyön alueelle edellyttää sen tehtävän selkiinnyttämistä kunkin ammatin koulutuksessa tai jatkokoulutuksessa, varsinkin ihmissuhdeammateissa. Työnohjausta käsitellään oppimisprosessina jossa juuri prosessien tarkastelu kehittyy. Dynaamisen työnohjauksen oppimistavoitteita tarkastellaan lähinnä työnohjaajan tehtävien kannalta Fleming & Benedekin mallin valossa. Esimerkkinä käytetään opettajankoulutusta, jossa tämänkaltainen työnohjaus koulutusvaiheessa edistäisi ammatillisen identiteetin kehittymistä. Lopuksi tarkastellaan lyhyesti ammatillisen roolin objektiivisia ja ammatillisen identiteetin subjektiivisia edellytyksiä ja asetetaan työnohjaus laajempaan, työyhteisö -yhteyteen.
Kulutuksesta tuottavuuden ja tehokkuuden osatekijäksi
Authors: Tuomisto Jukka
Published: August 2020

Artikkelissa analysoidaan, minkälaisille paradigmoille työnantajien koulutusajattelu on maassamme perustunut viime sotien jälkeisenä aikana. Koulutusajattelussa erotetaan sosiaalipoliittisen, koulutuksen taloustieteellisen ja henkilöstöhallinnollisen paradigman kaudet. Vaikka nämä kaudet eivät erotu käytännössä toisistaan aivan selvärajaisesti, niin yleisellä tasolla niiden erottaminen on suhteellisen selkeää. Nykyisin yritysten koulutustoimintaa ohjaavat entistä enemmän tehokkuus- ja taloudellisuustavoitteet, mistä on ollut seurauksena työvoiman kvalifikaatioiden polarisaatiokehitys.
Hajauta ja hallitse
Authors: Pihlajaniemi Toivo
Published: August 2020

Hallinnon hajauttamiskomitean (komiteanmietintö 1986:12) yhtenä sihteerinä toiminut kirjoittaja käsittelee artikkelissaan komitean työn lähtökohtia, tavoitteita ja ehdotuksia. Ehdotusten käsittelyssä keskitytään toisaalta hallintoa yleisesti koskeviin ja toisaalta opetus- ja aikuiskasvatushallintoa erityisesti koskeviin ehdotuksiin.
Pengaruh Ukuran Perusahaan, Debt To Equity Ratio, Return On Equity Dan Current Ratio Untuk Mengidentifikasi Financial Distress Pada Perusahaan Properti Yang Terdaftar Di Bursa Efek Indonesia Periode 2014-2017.
Authors: Sarina Silvia , Lubis Aprilia , Linda Linda
Published: August 2020

Penelitian ini bertujuan untuk menguji dan menganalisis bagaimana Ukuran Perusahaan, Debt To Equity Ratio, Return On Equity Dan Current Ratio untuk mengidentifikasi Financial Distress pada perusahaan properti yang terdaftar di Bursa Efek Indonesia periode 2014-2017. Penelitian ini merupakan penelitian kuantitatif. Populasi penelitian ini adalah perusahaan properti yang terdaftar di Bursa Efek Indonesia yang berjumlah 49 perusahaan. Sampel penelitian ini adalah 28 perusahaan yang diseleksi dengan teknik purposive sampling. Metode statistik yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa Ukuran Perusahaan, Debt To Equity Ratio, Return On Equity Dan Current Ratio dapat mengidentifikasi Financial Distress. Dan secara simultan Ukuran Perusahaan, Debt To Equity Ratio, Return On Equity Dan Current Ratio dapat mengidentifikasi Financial Distress. Besarnya koefisien determinasi sebesar 91,8% sedangkan sisanya sebesar 8,2% Financial Distress dijelaskan oleh variabel lain yang tidak diteliti dalam penelitian ini. Kesimpulan penelitian ini adalah secara parsial dan simultan Ukuran Perusahaan, Debt To Equity Ratio, Return On Equity Dan Current Ratio dapat mengidentifikasi Financial Distress pada perusahaan properti yang terdaftar di Bursa Efek Indonesia periode 2014-2017.
Komitmen Organisasi Auditor, Kelelahan, dan Keinginan untuk Pindah: Suatu Penelitian Replikasi
Authors: Nasution Dito Aditia Darma , Ramadhan Puja Rizqy , Erlina Erlina
Published: August 2020

Penelitian ini adalah penelitian replikasi dari penelitian yang dilakukan oleh Herda & Lavelle (2012) yang meneliti tentang komitmen organisasi auditor, kelelahan (burnout) dan keinginan untuk pindah (turnover intention). Penelitian replikasi yang kami lakukan adalah sebuah alternatif pengukuran komitmen yang telah dikonsep dan telah divalidasi secara empiris dalam literatur organisasi pengukuran komitmen KUT (Klein, et al, Unidimensional, Target-Free). Hasil dari penelitian replikasi yang telah kami lakukan menunjukkan bahwa adanya konsistensi yang tinggi dengan yang dilaporkan dalam penelitian asli, serta menunjukan bahwa hasil yang dilaporkan memiliki korelasi yang tinggi dan juga menunjukkan bahwa metode KUT dapat digunakan dengan efektif di dalam konteks penelitian akuntansi keprilakuan. Penelitian yang kami lakukan ini juga akan membahas beberapa konsep potensial dan manfaat praktis dari KUT sebagai bahan pertimbangan penelitian akuntansi keprilakuan dalam sistem akuntansi.
Faktor-Faktor Yang Mempengaruhi Manajemen Laba Pada Perusahaan Sektor Industri Barang Konsumsi di Bursa Efek Indonesia
Authors: Andini Rita , Amboningtyas Dheasey
Published: August 2020

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi manajemen laba pada perusahaan yang termasuk dalam Bursa Efek Indonesia (BEI). Variabel yang digunakan dalam menganalisis praktik manajemen laba yaituleverage, kepemilikan saham publik dan kepemilikan institusional. Penelitian dilakukan pada perusahaan sektor industry barang konsumsi yang terdaftar di Bursa Efek Indonesia (BEI) secara berturut-turut untuk periode 2013-2015. Teknik sampel yang digunakan adalan puposive sampling, sehingga diperoleh sebanyak 42 sampel perusahaan. Metode pengujian data menggunakan analisis linier berganda. Berdasarkan hasil pengujian data, diperoleh bahwa hasil penelitian ini adalah; leverage, dan kepemilikan institusional tidak berpengaruh, kepemilikan saham publik berpengaruh terhadap manajemen laba.
KEANEKARAGAMAN JENIS TUMBUHAN PAKU (PTERIDOPHYTA) DI KAWASAN HUTAN TUMBANG MANGGU, KECAMATAN SANAMAN MANTIKEI, KABUPATEN KATINGAN, KALIMANTAN TENGAH
Authors: Hartini Sri
Published: August 2020

Research on the diversity of ferns in the forests of Tumbang Manggu, Sub-district Sanaman Mantikei, Central Kalimantan, has been done. The study was conducted in March – April 2016  by using explorative methods. The results show, at least 28 species of ferns were found in the forest area, of which 16 species are terrestrial ferns and 12 species of epiphytic ferns. These species are included in 22 genera and 14 families. Huperzia and Pyrrosia are most abundant, each genus were consists of 3 species. The most rich families in term number of species are Polypodiaceae and Lycopodiaceae, with 6 species and 4 species respectively. Abundance of each species in the region was different, Blechnum orientale L., Dicranopteris linearis (Burm. f.) Underw., Lycopodiella cernua (L.) Pic. Serm., and Vittaria scolopendrina (Bory) Schkuhr ex Thwaites were found in large quantities and spread almost all over the region. Asplenium nidus L., Drynaria quercifolia (L.) J. Sm., Stenochlaena palustris (Burm. f.) Bedd., Lygodium circinatum (Burm. f.) Sw., Pyrrosia lanceolata (L.) Farw., Nephrolepis falcata (Cav.) C. Chr. and Vittaria ensiformis Sw. were found in considerable numbers. Asplenium pellucidum Lam., Athyrium bantamense Milde, Helminthostachys zeylanica (L.) Hook. and Tectaria crenata Cav. were found in small quantities and only in certain places. Local communities around the region have not much utilizing the ferns yet.
PENGARUH BERPIKIR KRITIS TERHADAP HASIL BELAJAR MATEMATIKA
Authors: Saputri Resti , Nurlela Nintin , Patras Yuyun Elizabeth
Published: August 2020

THE EFFECT OF CRITICAL THINKING ON MATHEMATICS LEARNING OUTCOMESThis research was conducted using an associative quantitative research approach with a type of causal approach consisting of two variables namely critical thinking as an independent variable and mathematics learning outcomes as the dependent variable. The main objective of this research is to find out the positive influence between critical thinking and mathematics learning outcomes. The subjects of this study were students of class IV-A. IV-B, and IV-C. Bogor City Pondok Rumput Elementary School consisting of 49 respondents. The research was carried out in the first semester of the 2019/2020 school year. The instrument validity test uses the Person Product Moment correlation formula and the reliability test uses the Cronbach Alpha formula. Test data analysis requirements using the test for normality, homogeneity, and linearity. The average value on the critical thinking variable was 109.7 and the average value on the mathematics learning variable was 68.1. Then the results of the study showed that there was an influence of critical thinking on mathematics learning outcomes, indicated by statistical analysis that produced a path coefficient (pxy) value of 0.64. This shows the influence of critical thinking on mathematics learning outcomes, while the coefficient of determination (r2) of 0.409 or 40.9%. This means the value of the influence of critical thinking on mathematics learning outcomes of 40.9%, through the regression equation The remaining 59.1% is determined by other factors. Based on the results of the research above, it can be concluded that there is a positive influence between critical thinking on students' mathematics learning outcomes. This means that one of the factors in mathematics learning outcomes is due to students' critical thinking at the time of learning.
PENGARUH PEMBERIAN HUKUMAN TERHADAP KEDISIPLINAN PESERTA DIDIK
Authors: Maulida Nurlita , Mirawati Mira , Anwar Wawan Syahiril
Published: August 2020

THE EFFECT OF PUNISHMENT OF THE DISCIPLINE OF STUDENTSThis research uses a causal quantitative research design. The purpose of this research is to determine the effect of punishment on the discipline of students. This research was conducted at Panaragan 1 Primary School in class V odd semester 2019/2020 school year. The population in the study amounted to 108 students and samples taken as many as 52 students were obtained using the Taro Yamane formula. The results showed that there was an effect of giving penalties on student discipline, indicated by statistical analysis which resulted in a correlation coefficient of 0.485. Data analysis techniques with regression analysis and path coefficients produce a model of influence expressed in the form of a regression equation that is Ŷ = 63.07 + 0.35X, with a Fcount value of 15.34 greater than Ftable with a significance level of 0.05 of 4, 03 and the contribution based on the results of the study amounted to 23.52% while 76.48% is influenced by other factors, it can be concluded that there is a positive and significant effect on the discipline of the fifth grade students of Panaragan State Elementary School 1 Odd Semester in the 2019/2020 school year
Desk Top Study: Challenges in Curriculum Development of TVET In preparation for the 21st century to Nepal.
Authors: Rijal Nimananda
Published: August 2020

The study is aimed to identify the need to develop the TVET Curriculum as required to the changing market scenario nationally and internationally. The study carried out with the dissection of the published literature. Development of the TVET curriculum in Nepal is a challenge since it is highly centralized, it is a set back to make it compatible with the market demand. The 4th Industrial revolution has been on the horizon, to prepare required human resources, the proper investment should be made in the TVET sectors by the government, at present it is 1%of the GDP, should be increased to 6% and research in TVET curriculum should be continued and flexible, the TVET institutes should be independent to adjust the curriculum as per the demand of the market. The trainer should be trained as per the changes that are occurred and Infrasturre should be updated accordingly.
Дністровська ескадра Чорноморського гребного флоту та її командир Христофор Бернард де Граве
Authors: Аргатюк Сергій , Сапожников Ігор
Published: August 2020

Стаття присвячена історії Дністровської ескадри, утвореної після російсько-турецької війни 1787-1791 рр., яка була бойовою одиницею Чорноморського Гребного флоту, що базувався у Миколаєві й Одесі. У ній описана біографія першого командуючого Дністровської флотилії Х.Б. де Граве, значна частина життя та діяльності якого була пов’язана з обома містами. У статті вперше опубліковані плани з позначенням флотських споруд в Овідіополі 1794 і 1798 рр., які виконали Ф.П. де Волан і Є.Х. Ферстер. У додатку поданий детальний звіт контр-адмірала П.В. Пустошкіна про навігаційну кампанію 1797 року, який проливає світло на структуру та діяльність усього Гребного флоту в часи правління імператора Павла І.
«Українські справи» анархістів – «повторників»
Authors: Савченко Віктор
Published: August 2020

Стаття висвітлює маловідому кампанію державного терору в радянській Україні у 1947-1949 рр. спрямованої проти анархістів, що зберегли свою вірність радикальній ідеології колишніх анархістів. У ці роки радянські каральні органи розгорнули новий етап знищення «підозрілих» елементів як «небезпечних державних злочинців», повторно арештовуючи та відправляючи у табори і заслання анархістів, які відбули всі свої вироки й опинилися на поселенні або на волі. На конкретних прикладах відомих історичних осіб: лідера і теоретика анархізму А. Андрєєва та його дружини З. Гандлєвської, махновського командира та пропагандиста М. Уралова і звичайних «незадоволених режимом» громадян, котрі допускали «ліві» радикальні висловлювання щодо радянського ладу, проводиться аналіз необґрунтованої (з точки права та логіки) кампанії державного терору. Долі жертв показують, що сталінський режим був спрямований на повне духовне та правове підкорення народу.
Залишки будівельних споруд «цитаделі» городища Дикий Сад
Authors: Горбенко Кирило
Published: August 2020

Розглядається характер, структура та конструктивні особливості залишків будівельних споруд «цитаделі» городища доби фінального бронзового віку Дикий Сад (13/12-12/11 ст. до н.е.).

Надається локалізація й опис характерних речей у заповнені та закритих комплексах споруд (керамічний посуд, предмети з глини, бронзи, каменю, кістки та рогу).

Усі споруди «цитаделі» є характерними (окрім рову) для пам’яток Північно-Західного Причорномор’я доби пізньої бронзи. При цьому, принцип розміщення будівель, враховуючи оборонні споруди навколо «цитаделі», вказує й на традиції, що характерні для східного ареалу культур бронзового віку.
The STRidER Report on Two Years of Quality Control of Autosomal STR Population Datasets
Authors: Bodner Martin , Parson Walther
Published: August 2020

STRidER, the STRs for Identity ENFSI Reference Database, is a curated, freely publicly available online allele frequency database, quality control (QC) and software platform for autosomal Short Tandem Repeats (STRs) developed under the endorsement of the International Society for Forensic Genetics. Continuous updates comprise additional STR loci and populations in the frequency database and many further STR-related aspects. One significant innovation is the autosomal STR data QC provided prior to publication of datasets. Such scrutiny was lacking previously, leaving QC to authors, reviewers and editors, which led to an unacceptably high error rate in scientific papers. The results from scrutinizing 184 STR datasets containing >177,000 individual genotypes submitted in the first two years of STRidER QC since 2017 revealed that about two-thirds of the STR datasets were either being withdrawn by the authors after initial feedback or rejected based on a conservative error rate. Almost no error-free submissions were received, which clearly shows that centralized QC and data curation are essential to maintain the high-quality standard required in forensic genetics. While many errors had minor impact on the resulting allele frequencies, multiple error categories were commonly found within single datasets. Several datasets contained serious flaws. We discuss the factors that caused the errors to draw the attention to redundant pitfalls and thus contribute to better quality of autosomal STR datasets and allele frequency reports.
Extracurricular Functions of tRNA Modifications in Microorganisms
Authors: Edwards Ashley M. , Addo Maame A. , Dos Santos Patricia C.
Published: August 2020

Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational competency and promote cellular viability. Hence, the placement and prevalence of tRNA modifications affects the efficiency of aminoacyl tRNA synthetase (aaRS) reactions, interactions with the ribosome, and transient pairing with messenger RNA (mRNA). The synthesis and abundance of tRNA modifications respond directly and indirectly to a range of environmental and nutritional factors involved in the maintenance of metabolic homeostasis. The dynamic landscape of the tRNA epitranscriptome suggests a role for tRNA modifications as markers of cellular status and regulators of translational capacity. This review discusses the non-canonical roles that tRNA modifications play in central metabolic processes and how their levels are modulated in response to a range of cellular demands.
Quantitative Proteomics Comparison of Total Expressed Proteomes of Anisakis simplex Sensu Stricto, A. pegreffii, and Their Hybrid Genotype
Authors: C. Arcos Susana , Robertson Lee , Ciordia Sergio , Sánchez-Alonso Isabel , Careche Mercedes , Carballeda-Sanguiao Noelia , Gonzalez-Muñoz Miguel , Navas Alfonso
Published: August 2020

The total proteomes of Anisakis simplex s.s., A. pegreffii and their hybrid genotype have been compared by quantitative proteomics (iTRAQ approach), which considers the level of expressed proteins. Comparison was made by means of two independent experiments considering four biological replicates of A. simplex and two each for A. pegreffii and hybrid between both species. A total of 1811 and 1976 proteins have been respectively identified in the experiments using public databases. One hundred ninety-six proteins were found significantly differentially expressed, and their relationships with the nematodes’ biological replicates were estimated by a multidimensional statistical approach. Results of pairwise Log2 ratio comparisons among them were statistically treated and supported in order to convert them into discrete character states. Principal component analysis (PCA) confirms the validity of the method. This comparison selected thirty seven proteins as discriminant taxonomic biomarkers among A. simplex, A. pegreffii and their hybrid genotype; 19 of these biomarkers, encoded by ten loci, are specific allergens of Anisakis (Ani s7, Ani s8, Ani s12, and Ani s14) and other (Ancylostoma secreted) is a common nematodes venom allergen. The rest of the markers comprise four unknown or non-characterized proteins; five different proteins (leucine) related to innate immunity, four proteolytic proteins (metalloendopeptidases), a lipase, a mitochondrial translocase protein, a neurotransmitter, a thyroxine transporter, and a structural collagen protein. The proposed methodology (proteomics and statistical) solidly characterize a set of proteins that are susceptible to take advantage of the new targeted proteomics.
Using Micro- and Macro-Level Network Metrics Unveils Top Communicative Gene Modules in Psoriasis
Authors: Naderi Reyhaneh , Saadati Mollaei Homa , Elofsson Arne , Hosseini Ashtiani Saman
Published: August 2020

(1) Background: Psoriasis is a multifactorial chronic inflammatory disorder of the skin, with significant morbidity, characterized by hyperproliferation of the epidermis. Even though psoriasis’ etiology is not fully understood, it is believed to be multifactorial, with numerous key components. (2) Methods: In order to cast light on the complex molecular interactions in psoriasis vulgaris at both protein–protein interactions and transcriptomics levels, we studied a set of microarray gene expression analyses consisting of 170 paired lesional and non-lesional samples. Afterwards, a network analysis was conducted on the protein–protein interaction network of differentially expressed genes based on micro- and macro-level network metrics at a systemic level standpoint. (3) Results: We found 17 top communicative genes, all of which were experimentally proven to be pivotal in psoriasis, which were identified in two modules, namely the cell cycle and immune system. Intra- and inter-gene interaction subnetworks from the top communicative genes might provide further insight into the corresponding characteristic interactions. (4) Conclusions: Potential gene combinations for therapeutic/diagnostics purposes were identified. Moreover, our proposed workflow could be of interest to a broader range of future biological network analysis studies.
EST–SNP Study of Olea europaea L. Uncovers Functional Polymorphisms between Cultivated and Wild Olives
Authors: Mariotti Roberto , Belaj Angjelina , De La Rosa Raul , Leòn Lorenzo , Brizioli Federico , Baldoni Luciana , Mousavi Soraya
Published: August 2020

Background: The species Olea europaea includes cultivated varieties (subsp. europaea var. europaea), wild plants (subsp. europaea var. sylvestris), and five other subspecies spread over almost all continents. Single nucleotide polymorphisms in the expressed sequence tag able to underline intra-species differentiation are not yet identified, beyond a few plastidial markers. Methods: In the present work, more than 1000 transcript-specific SNP markers obtained by the genotyping of 260 individuals were studied. These genotypes included cultivated, oleasters, and samples of subspecies guanchica, and were analyzed in silico, in order to identify polymorphisms on key genes distinguishing different Olea europaea forms. Results: Phylogeny inference and principal coordinate analysis allowed to detect two distinct clusters, clearly separating wilds and guanchica samples from cultivated olives, meanwhile the structure analysis made possible to differentiate these three groups. Sequences carrying the polymorphisms that distinguished wild and cultivated olives were analyzed and annotated, allowing to identify 124 candidate genes that have a functional role in flower development, stress response, or involvement in important metabolic pathways. Signatures of selection that occurred during olive domestication, were detected and reported. Conclusion: This deep EST–SNP analysis provided important information on the genetic and genomic diversity of the olive complex, opening new opportunities to detect gene polymorphisms with potential functional and evolutionary roles, and to apply them in genomics-assisted breeding, highlighting the importance of olive germplasm conservation.
Posture and Time Arrangement Influence Shank Circumference Reduction When Performing Leg Raising Exercise
Authors: Chen Yi-Lang , Cheng Ya-Ting , Ye Jia-Ning , Huang Tzu-Ling , Chen Wen-Ning
Published: August 2020

This study recruited nine young women who performed a leg raising exercise under six test combinations of three holding postures (lying supine, placing the shanks on a yoga ball, and elevating the legs at 60° against the wall) and two time arrangements (continuous vs. intermittent) for a period of 15 min. The intermittent arrangement included an additional 1-min rest set in the middle of the 15 min test. The participants’ shank circumference (SC) reductions and discomfort ratings were measured after each test combination was performed. Results indicated that the most efficient method for SC reduction was the yoga ball (5.4 mm), followed by the supine lying posture (4.6 mm) and wall-supported leg raising (3.1 mm). A significant interaction of posture × time arrangement (p < 0.01) implied that the yoga ball method combined with a 1-min rest produced the greatest SC reduction (6.7 mm). Our results also showed that participants experienced the greatest discomfort (score: 4.96) when performing wall-supported leg raising, compared with both lying supine (score: 1.34) and the yoga ball (score: 1.32). This study suggests that the effectiveness of leg raising as conventionally practiced for eliminating leg fatigue or swelling requires further consideration.
Media Coverage of Pedophilia: Benefits and Risks from Healthcare Practitioners’ Point of View
Authors: Stelzmann Daniela , Jahnke Sara , Kuhle Laura F.
Published: August 2020

The fierce stigma associated with pedophilia may interfere with attempts to prevent sexual offending. Prior research on the effects of media reports about pedophilia mostly focused on their role in perpetuating stigma in the general population. In order to better understand potential benefits and risks of the media coverage on people with pedophilia and specialized prevention and treatment efforts, we conducted semi-structured qualitative interviews with 11 healthcare practitioners of the German Prevention Network “Don’t offend”. Healthcare practitioners described positive (e.g., raising awareness for prevention offers) as well as negative (e.g., perpetuating the existing public stigma) effects of the media coverage and estimated that only about one-third of media coverage portrays pedophilia realistically. To destigmatize pedophilia and benefit the prevention of child sexual abuse, a fact box for journalists was developed based on practitioners’ expert knowledge.
Neighborhood Disadvantage Is Associated with Depressive Symptoms but Not Depression Diagnosis in Older Adults
Authors: Bolstad Courtney J. , Moak Reagan , Brown Cynthia J. , Kennedy Richard E. , Buys David R.
Published: August 2020

Disadvantaged neighborhood environments may have low access to healthcare, perpetuating health disparities. Previous research has reported on associations between neighborhood disadvantage (ND) and depressive symptomology but not depression diagnoses, which may indicate access to healthcare. This study tested how ND relates to depressive symptomology and diagnosis to assess for neighborhood disparities in mental health care cross-sectionally. Data from 998 community-dwelling, Black and White individuals aged 65+ included in the University of Alabama at Birmingham Study of Aging were analyzed. We obtained participants’ depressive symptomology from the Geriatric Depression Scale (n = 100) and a verified depression diagnosis from self-report and review of medication, physician-report, and/or hospital discharge summaries (n = 84). We assessed ND from US Census data, divided the sample into tertiles of ND and fit models with Generalized Estimating Equations covarying for various other variables (e.g., sex, race, physical performance, socioeconomic status, etc.). We found living in the high and mid-ND tertiles to be associated with depressive symptomology, yet ND had no significant relation to depression diagnosis. Therefore, older adults living in high and mid-disadvantaged neighborhoods may be more likely to experience depressive symptomology but not receive a diagnosis, indicating a possible disparity in mental health care.
When It Is Not Measured, How Then Will It Be Planned for? WaSH a Critical Indicator for Universal Health Coverage in Kenya
Authors: Abu Thelma Zulfawu , Elliott Susan J.
Published: August 2020

The quality and safety of healthcare facility (HCF) services are critical to achieving universal health coverage (UHC) and yet the WHO/UNICEF joint monitoring program for water supply, sanitation and hygiene report indicates that only 51% and 23% of HCF in Sub-Saharan Africa have basic access to water and sanitation, respectively. Global commitments on improving access to water, sanitation, hygiene, waste management and environmental cleaning (WaSH) in HCF as part of implementing UHC have surged since 2015. Guided by political ecology of health theory, we explored the country level commitment to ensuring access to WaSH in HCFs as part of piloting UHC in Kisumu, Kenya. Through content analysis, 17 relevant policy documents were systematically reviewed using NVIVO. None of the national documents mentioned all the component of WaSH in healthcare facilities. Furthermore, these WaSH components are not measured as part of the universal health coverage pilot. Comprehensively incorporating WaSH measurement and monitoring in HCFs in the context of UHC policies creates a foundation for achieving SDG 6.
Work-Related Identity Discrepancy and Counterproductive Work Behavior: The Role of Emotional Exhaustion and Supervisor Incivility
Authors: Liu Chang-E , Yuan Xiao , Hu Chenhong , Liu Tingting , Chen Yahui , He Wei
Published: August 2020

This research investigates the role of emotional exhaustion and supervisor incivility in explaining the relationship between work-related identity discrepancy and counterproductive work behavior. Based on resource conservation theory, our study hypothesizes a moderated mediation model that work-related identity discrepancy impacts counterproductive work behavior through emotional exhaustion, and supervisor incivility is deemed as the boundary condition in the indirect effect. Drawing on a sample of 863 employees, we found support for the moderated mediation model in which the positive relationship between work-related identity discrepancy and counterproductive work behavior was mediated by emotional exhaustion, such that the mediating relationship was strengthened for new leaders with a low level of supervisor incivility and weakened for those with high level of supervisor incivility. We further discuss the theoretical and practical implications of these findings.
Daily Empowering Leadership and Job Crafting: Examining Moderators
Authors: Tang Shangbiao , Zhang Guanglei , Wang Hai-Jiang
Published: August 2020

In this study, we built and tested a contingency model linking leader daily empowering behaviors with employee daily job crafting. Drawing on the contingency leadership literature and the model of proactive motivation, we theorized employee daily work meaning and vigor as moderators of the above relationships. Daily data were collected from 103 Chinese employees for five consecutive days. Our findings suggest that leader dayT (a certain day) empowering behaviors are more strongly related to employee dayT+1 (next day after the certain day) job crafting when employee dayT work meaning is low and employee dayT+1 vigor is high. Our findings suggest that only under certain conditions can empowering leadership promote employee job crafting on a daily basis.
Nutrition Labeling Usage Influences Blood Markers in Body-Size Self-Conscious Individuals: The Korean National Health and Nutrition Examination Survey (KNHANES) 2013–2018
Authors: Kye Su Yeon , Han Kyu-Tae , Jeong Sung Hoon , Choi Jin Young
Published: August 2020

This study analyzed the effects of nutrition labeling and examined whether nutrition labeling usage influences the levels of blood markers, such as high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) in body-size self-conscious individuals. The dependent variables were HDL-C and TG; the independent variables were the respondents’ awareness of nutrition labeling use, sociodemographic factors, perceived health status, stress, lifestyle, frequency of eating out, family history of hyperlipidemia, survey year, body mass index, total energy intake, and cholesterol levels. Body-size perception was assessed by matching body mass index with subjective body-shape recognition using data from the Korean National Health and Nutrition Examination Survey (2013–2018). Differences were observed in HDL-C and TG levels according to nutrition labeling usage and body-image perception. The group that recognized body image correctly showed high HDL-C and low TG levels when they actively used nutrition labeling, whereas the group that recognized body image incorrectly showed no significant changes in HDL-C and TG levels even when actively using nutrition labeling. The standard nutritional information, which does not consider individual body-size perceptions, has a restrictive effect. Policies should be developed towards tailored intervention strategies considering individual body-size perception.
Profiles on the Orientation Discrimination Processing of Human Faces
Authors: Moret-Tatay Carmen , Baixauli-Fortea Inmaculada , Grau-Sevilla M. Dolores
Published: August 2020

Face recognition is a crucial subject for public health, as socialization is one of the main characteristics for full citizenship. However, good recognizers would be distinguished, not only by the number of faces they discriminate but also by the number of rejected stimuli as unfamiliar. When it comes to face recognition, it is important to remember that position, to some extent, would not entail a high cognitive cost, unlike other processes in similar areas of the brain. The aim of this paper was to examine participant’s recognition profiles according to face position. For this reason, a recognition task was carried out by employing the Karolinska Directed Emotional Faces. Reaction times and accuracy were employed as dependent variables and a cluster analysis was carried out. A total of two profiles were identified in participants’ performance, which differ in position in terms of reaction times but not accuracy. The results can be described as follows: first, it is possible to identify performance profiles in visual recognition of faces that differ in position in terms of reaction times, not accuracy; secondly, results suggest a bias towards the left. At the applied level, this could be of interest with a view to conducting training programs in face recognition.
The Relationship between Maternal Personality Disorder and Early Birth Outcomes: A Systematic Review and Meta-Analysis
Authors: Marshall Claire A. , Jomeen Julie , Huang Chao , Martin Colin R.
Published: August 2020

(1) Background: Women with personality disorder are at risk of social and emotional problems which impact deleteriously on everyday functioning. Moreover, a personality disorder diagnosis has been established to have an adverse impact upon pregnancy outcomes and child health. Understanding this impact is critical to improving both maternal and child outcomes. This systematic review and meta-analysis will evaluate the contemporary evidence regarding these relationships. (2) Methods: Prospero and Cochrane were searched for any systematic reviews already completed on this topic. Academic Search Premier, CINAHL Complete, MEDLINE, PsycARTICLES, PsycINFO via the EBSCO host, and the Web of Science Core Collection were searched to include research articles published between 1980 and 2019. A total of 158 records were identified; 105 records were screened by reviewing the abstract; 99 records were excluded; 6 full text articles were assessed for eligibility; 5 records were included in the review. (3) Results: All the included studies reported on preterm birth. The meta-analysis indicates significant risk of preterm birth in women with personality disorder (overall odds ratio (OR) 2.62; CI 2.24–3.06; p < 0.01). Three studies reported on low birth weight, with the meta-analysis indicating a raised risk of low birth weight of the babies born to women with personality disorder (overall OR 2.00 CI 1.12–3.57 (p = 0.02)). Three studies reported on appearance, pulse, grimace, activity, and respiration (APGAR) score, with the meta-analysis of OR’s indicating a risk of low APGAR score in women with personality disorder (overall OR 2.31; CI 1.17–4.55; p = 0.02). (4) Conclusions: The infants of women with personality disorder are at elevated risk of preterm birth, low birth weight and low APGAR score.
Be Healthe for Your Heart: A Pilot Randomized Controlled Trial Evaluating a Web-Based Behavioral Intervention to Improve the Cardiovascular Health of Women with a History of Preeclampsia
Authors: Hutchesson Melinda J. , Taylor Rachael , Shrewsbury Vanessa A. , Vincze Lisa , Campbell Linda E. , Callister Robin , Park Felicity , Schumacher Tracy L. , Collins Clare E.
Published: August 2020

This pilot randomized controlled trial (RCT) aimed to determine the acceptability and preliminary efficacy of a web-based cardiovascular disease (CVD) prevention intervention for women following preeclampsia. Australian women with a recent history (≤4 years post diagnosis) of preeclampsia were randomized into two study arms: (1) Be Healthe for your Heart, a web-based behavioral intervention or; (2) Control, access to the National Heart Foundation website. Assessments were conducted at baseline, and after three months. Intervention acceptability and impact on absolute CVD 30-year risk score, CVD risk markers and health behaviors were assessed. Twenty-four of 31 (77.4%) women completed the three-month assessment. Eleven out of 13 intervention participants (84.6%) agreed/strongly agreed they were satisfied with the program, with a mean score of 4.2 ± 0.9 (maximum of five). There were no significant between or within group differences in absolute CVD risk, CVD risk markers or health behaviors from baseline to three months. Women with a history of preeclampsia were successfully recruited and retained and they reported high levels of acceptability with the Be Healthe for your Heart program. Further research is therefore needed from powered trials to determine the impact of web-based lifestyle interventions on CVD risk in this at-risk group.
Spatial Distribution and Environmental Significance of Phosphorus Fractions in River Sediments and Its Influencing Factor from Hongze and Tiaoxi Watersheds, Eastern China
Authors: Marip Ja Bawk , Yuan Xuyin , Zhu Hai , Nooni Isaac Kwesi , Amankwah Solomon O. Y. , Prempeh Nana Agyemang , Norgbey Eyram , Yuguda Taitiya Kenneth , Khaing Zaw Myo
Published: August 2020

This study explored the spatial distribution of phosphorus fractions in river sediments and analyzed the relationship between different phosphorus fractions and their environmental influence on the sediments within different watersheds in Eastern China. River sediments from two inflow watersheds (Hongze and Tiaoxi) to Hongze and Taihu Lake in Eastern China were analyzed by the sequential extraction procedure. Five fractions of sedimentary phosphorus, including freely sorbed phosphorus (NH4Cl-P), redox-sensitive phosphorus (BD-P), bound phosphorus metal oxide (NaOH-P), bound phosphorus calcium (HCl-P), and residual phosphorus (Res-P) were all analyzed. The orders of rankings for the P fractions of the rivers Anhe and Suihe were HCl-P > NaOH-P > BD-P > NH4Cl-P and HCl-P > BD-P > NaOH-P > NH4Cl-P, respectively. For the rank order of the Hongze watershed, HCl-P was higher while the NH4Cl-P contents were significantly lower. The rank order for the Dongtiaoxi River was NaOH-P > HCl-P > BD-P > NH4Cl-P, and that of Xitiaoxi River was NaOH-P > BD-P > HCl-P > NH4Cl-P. Compared with the phosphorus forms of the Tiaoxi watershed, NaOH-P contents were significantly higher compared to HCl-P, which was significantly higher in the Hongze watershed. In comparison, NH4Cl-P contents were significantly lower in both. Variations may be attributed to differential discharge of the P form in the watershed due to land-use changes and urban river ambient conditions.
Subnational Burden of Disease According to the Sociodemographic Index in South Korea
Authors: Go Dun-Sol , Kim Young-Eun , Yoon Seok-Jun
Published: August 2020

The sociodemographic index (SDI), a composite index per capita income, educational attainment, and total fertility rate in a country, can indicate whether the country’s burden of disease varies depending upon its level of socioeconomic development. This study identified the subnational SDI and disease burden of South Korea based on the country’s overall SDI, using national representative data. The burden of disease was measured using disability-adjusted life years (DALY) with an incidence-based approach. We used National Health Insurance Services claims data to estimate the years lived with disability (YLD) and cause-of-death statistics to estimate the years of life lost (YLL). Indicators of subnational SDI were also extracted. The Korean subnational SDIs for 250 regions were correlated with YLL, YLD, and DALY for the year 2016. The correlation between SDI and YLL was stronger in big cities than in medium areas and small areas. Moreover, the higher the SDI, the higher the coefficient. The SDI should be used as a standard for interpreting and comparing regions’ disease burden at the subnational level.
Capacity Sharing and Capacity Investment of Environment-Friendly Manufacturing: Strategy Selection and Performance Analysis
Authors: Xie Lei , Han Hongshuai
Published: August 2020

Many small manufacturing factories suffer insufficient environment-friendly capacity after eliminating the outdated and environmental-harmful production capacity according to stringent environmental rules and regulations. This paper analyzes two strategies that the manufacturer with limited environment-friendly capacity may take to tackle this problem, i.e., investing in building environment-friendly capacities and collaborating with the manufacturer with sufficient environment-friendly capacity in capacity sharing. In a supply chain with two competing manufacturers, this paper builds game-theoretical models and investigates equilibrium solutions under three scenarios (no capacity investment or sharing, capacity investment, and capacity sharing). Then this research investigates the feasible regions of these two strategies and compares the performance of each manufacturer under each scenario. The findings show that both capacity investment and capacity sharing can effectively reduce the profit loss of the manufacturer with limited capacity, while only capacity sharing benefits both manufacturers. The feasibility of these two strategies depends on the initial capacity volume and the capacity investment cost coefficient of the manufacturer with limited capacity. Moreover, the preference of the manufacturer with limited capacity for each strategy depends on the capacity investment cost coefficient. When the capacity investment cost coefficient is relatively high, the win-win situation exists for supply chain members. Furthermore, with the use of chaos theory, the paper shows how to adjust the capacity investment in each period to keep the system stable.