bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Vineyard Task Planning: Constraint Programming Based Tool with Customizable Domain
Authors: Pujol Alex , Fabregat Raimón , Pijuan Josep , Otero Marta , Torres Montse , Dente Antonio , Alves Fernando
Published: September 2024

Producing grapes for wine is a complex and delicate process that requires meticulous execution of numerous tasks to reach the desired quality and yield. Wine producers dedicate many resources to specialized teams, from vine pruning in the early months of the year to harvesting when the fruit is ripe. Scheduling the available workforce and resources to complete these tasks optimally is of utmost importance. In this context, parting from an initial schedule could assist in the decision-making process and enhance the outcomes. With this objective, the Vitigeoss Business Service has been developed within the context of the Vitigeoss project. It is a generalized scheduling tool based on Constraint Programming, which assigns tasks to work teams on specific timeslots. For this, it uses First Fit Decreasing and Local Search as search algorithms. It also offers the capabilities of choosing between a set of constraints defined alongside wine producers, and focusing on one of three objective functions: time, cost, and environmental impact. In this document, a series of updates on the constraint decision process and customization of the domain are introduced, and its implications for the results obtained are analized. The Vitigeoss Business Service was available during the 2023 campaign, and its results have been validated with actual planning data from three use cases, showing improvements in the use of resources and finalization time.
A Complete Tableau Calculus for Non-Clausal Regular MinSAT
Authors: Coll Jordi , Li Chu-Min , Manyà Felip , Yangin Elifnaz
Published: September 2024

We define a tableau calculus for solving the Minimum Satisfiability problem for regular propositional logic, also known as Non-Clausal Regular MinSAT problem. Given a multiset of hard and weighted regular formulas Φ, the tableau calculus allows to find an assignment that satisfies the hard formulas and minimizes the sum of weights of the satisfied weighted regular formulas.
Polyp Re-Identification System for Video Capsule Endoscopy Studies
Authors: Laiz Pablo , Wenzek Hagen
Published: September 2024

This paper introduces an AI-based system designed to enhance the efficiency of early polyp detection by reviewing video capsule endoscopy (VCE) studies. This system avoids the repetitive examination of frames within the same sequence. To achieve this, the proposed system employs a re-identification approach to detect frames containing polyps of the same location without additional diagnostic information. The system achieves a precision of 88.08% and a sensitivity of 74.07%, with a low false positive rate of 0.12% in the re-identification task. Furthermore, a simulation using the ”super expert” metric indicates that our model enhances the detection of polyps by 13.56% in comparison to existing methods. These results demonstrate that the proposed system not only accurately re-identifies polyps but also optimizes the VCE review process by reducing the number of similar images that experts need to examine, thereby enhancing diagnostic efficiency.
Studies to determine the influence of the basicity modulus on the qualitative and quantitative indicators of production technology and the material composition of the sintere
Authors: Isaenko G. E. , Neugodov D. A. , Kim G. A. , Nechkin G. A. , Makavetskas A. R.
Published: September 2024

In recent years, the increase in the efficiency of the blast furnace process is largely associated with the use of sinter with improved metallurgical properties. In the blast furnace charge of PJSC NLMK, the share of sinter is 60–75% with a change in basicity from 1.3 to 1.8. Studying the material composition of agglomerates of different basicity and their characteristics allows us to adjust the technological process and determine the optimal modulus of basicity depending on specific conditions. Agglomerates with a basicity index of: 1.3; 1.4; 1.5; 1.6; 1.7 and 1.8. As a result of the research, it was established that the maximum vertical sintering speed and specific productivity of the sintering process correspond to the basicity of the sinter of 1.7. The influence of the basicity of the agglomerate on its strength is extreme, with a basicity of 1.4 the minimum strength of the agglomerate was obtained. Increasing the basicity of the agglomerate by more than 1.4 monotonically increases its strength. The nature of the change in the strength of the ag-glomerate with a change in basicity is determined by the mineral composition of the binder and is associated with a decrease in the proportion of glass in the structure of the agglomerate and an increase in the proportion of the crystalline silicate-ferrite binder. When studying the material composition, it was established that the samples of agglomerates have an identical phase composition, but differ in the phase ratio. Crystallization of calcium ferrites in contact with iron oxides contributes to the strengthening of the agglomerate, and the presence of impurities (Al, Si, Mg) in them increases the melting point. As a result of mineralogical and analytical studies, it was established that the highest metallurgical properties are found in agglomerates with a basicity modulus of 1.6–1.8.
Effect of Clomiphene Citrate on Fertility Hormones in Women with Polycystic Ovarian Syndrome
Authors: Arshad Asma , Rehman Kashif Ur , Butt Hamama Islam , Bashir Shahzad , Umar Fatima , Yaseen Zahida , Zahra Kashish , Bakhsh Ahmad
Published: September 2024

This study aims to investigate the positive effect of Clomiphene Citrate (CC) in inducing ovulation in women with PCOS. Clomiphene Citrate is a non-steroidal drug that primarily affects estrogen production. CC also has pronounced effects on balancing of the female hormones, normal ovulation process, and overcoming the PCOS-based infertility issues. Hormonal profile evaluation including follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, and estrogen was performed at Clinical Laboratory, Services Hospital, Lahore. Serum volume of the aforementioned hormones were determined in PCOS-suffering infertile women (n=50) and healthy fertile women (n=50) by using a commercially available ELISA kit manufactured by Calbotech lnc. Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone, and estrogen mean values in PCOS patients before the use of CC were evaluated as 5.74±0.939 (IU/L), 3.804±1.163 (IU/L), 2.098±1.233 (ng/ml), and (51.458±7.091 pg/ml respectively, while after management with CC the mean value of serum LH, FSH, Progesterone, and Estrogen were 3.716±0.513 (IU/L), 5.644±1.130 (IU/L), 10.704±2.313 ng/ml and 37.72±4.969 pg/ml respectively, which indicated a significant differences in hormonal pattern . The current study demonstrates that Clomiphene Citrate (CC) has positive effects in ovulation process in females with polycystic ovarian syndrome (PCOS), within the local population.
The Comparison of Scar Mobilization Techniques with and without Core Stability Exercises on Scar Tissue Mobility and Lumbopelvic Pain
Authors: Zahra Anam , Fatima Ghulam , Ikram Mehwish
Published: September 2024

Abdominal adhesions and lumbopelvic pain can occur after a caesarean section. Many treatment approaches, such as injections, massage, surgical release, soft tissue release, strengthening, stretching and core stability exercises are available for abdominal scars. Physiotherapy treatments are considered safer and more convenient. The study aims to compare the effects of scar mobilization techniques with and without core stability exercises on scar tissue mobility and lumbopelvic pain. The study was a randomized clinical trial conducted at the Rafiqa Hospital and Fatima Hospital, Sargodha, Pakistan. A sample of 30 participants was allocated in Group A and B. Group A received scar mobilization and core stability exercises, while Group B received only scar mobilization, with both groups undergoing 3 sessions per week for total three weeks. The groups were assessed at baseline after the 5th and 9th sessions, using Oswestry Low Back Pain Disability Questionnaire (ODI), Numeric Pain Rating Scale (NPRS), Manual Scar Mobility Testing (MSMT), and Vancouver Scar Scale (VSS). Moreover, the data were analyzed using SPSS 25. The mean age of participants was 27.22 ± 4.21, and their body mass index was 27.10 ± 3.53. Both groups showed significant differences within the subject’s scores of disability, pain and scar mobility (p<0.05). Between-group comparison of both groups at post-treatment II showed considerable improvement in pain scores (NPRS score, p<0.05). Whereas non-significant results were in other outcome measures (disability and scar mobility p>0.05) in post-treatment II. Scar mobilization techniques with core stability exercises were more effective than scar mobilization techniques alone in the conservative treatment of females with lumbopelvic and scar pain after caesarean section.
Synergistic Effect of Glibenclamide Combining With Vitexin on Type 2 Diabetes Mellitus Rats
Authors: Cai Yunwen , Huang Yongwei , Zhang Dongping , Wang Tiejun
Published: September 2024

Background & objectives: The combination of drugs with herbs is a prevalent treatment for metabolic and chronic diseases. This study combined glibenclamide with vitexin and performed in vivo and in vitro investigations, aiming to evaluate their synergistic effect on type 2 diabetes mellitus (T2DM).
Materials and methods: T2DM rat models were established by injecting streptozotocin, and the sham group was injected with a normal saline solution as the control. A single dosage was orally performed with 10 mg/kg glibenclamide, while the co-administrated was conducted by the pre-treatment of 20 mg/kg vitexin for 7 d to avoid potential chemical interactions. The pharmacokinetics of glibenclamide was evaluated in both sham and T2DM rats. The blood glucose of T2DM rats was detected in the presence of different administration strategies. The metabolic stability of glibenclamide was assessed in rat liver microsomes.
Results: Glibenclamide showed a significant hypoglycemic effect on T2DM rats, which was enhanced by the co-administration of vitexin. Vitexin significantly affected the pharmacokinetics of glibenclamide in both sham and T2DM rats, where the AUC0-t, Cmax, and t1/2 of glibenclamide significantly increased, and the clearance rate decreased. Moreover, vitexin increased the in vitro half-life and decreased intrinsic clearance of glibenclamide in rat liver microsomes. The previously reported inhibitory effect of vitexin on CYP2C9 activity was hypothesized as the mechanism underlying the interaction.
Conclusion: Co-administration of glibenclamide and vitexin would increase the systemic exposure and metabolic stability of glibenclamide and exert a synergistic effect on T2DM.
One-Pot Synthesis of New Bipyridine and Yerpyridine Derivatives: Anti-proliferative Evaluation, DNA Flow Cytometry Analysis, and Molecular Docking Study
Authors: Abd Elhady Hebe , AL-SHAREEF Hossa , Takroni Khadeega , Alharbi Wedad
Published: September 2024

Some new bipyridine derivatives were synthesized using 2-oxo-4-(pyridin-3-yl)-6-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile 1a. While terpyridine derivatives were synthesized using 2-oxo-4-(pyridin-3-yl)-6-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile 1b as starting material. Alkylation of compounds 1a, b gave the alkyl derivatives 2a, b which converted into aceto hydrazides 3a,b. Treating the aceto hydrazides with ethyl cyanoacetate afforded 2'-(2-(3,5-dioxopyrazolidin-1-yl)-2-oxoethoxy)-6'-(thiophen-2-yl)-3,4'-bipyridine-3'-carbonitrile 4a and 6'-[2-(3,5-dioxopyrazolidin-1-yl)-2-oxoethoxy]-(3,4':2',4''-terpyridine)-5'-carbonitrile 4b. While treatment of 3a, b with ethyl benzoylacetate afforded the carboniltrile derivatives 2'-(2-oxo-2-(5-oxo-3-phenyl-4,5-dihydropyrazol-1-yl)ethoxy)-6'-(thiophen-2-yl)-3,4'-bipyridine-3'-carbonitrile 5a and 6'-[2-oxo-2-(5-oxo-3-phenyl-4,5-dihydropyrazol-1-yl)ethoxy]-(3,4':2',4''-terpyridine)-5' carbonitrile 5b. Treating compounds 3a, and b with two aromatic aldehydes (3,4-dihydroxy benzaldehyde, 4-chlorobenzaldehyde) afforded Schiff bases 6a-d. Finally, treatment of 3a, b with p-toluenesulfonyl chloride (Tosyl chloride) afforded the corresponding benzene sulfonohydrazide 7a, b. IR, 1HNMR, 13CNMR, MS, and elemental analysis confirmed the synthesized compounds. The anti-cancer activity of the compounds was investigated against the breast cancer (MCF-7) cell line. Compound 6b demonstrated the strongest cytotoxic activity among the tested compounds and it is more active than the reference drug 5-fluorouracil (5-FU), so that, it is subjected to further investigations, where its effect on the cell cycle distribution in the MCF-7 cell line, its ability to inhibit Topoisomerase II, the level of Caspase‐3/7 green flow cytometry assay was investigated. Also, Molecular operating environmental docking (MOE) has been studied and found that the inhibition efficiency could be organized as follows (S, Kcal/mol) values: 5b ˃ 6d ˃ 3a ˃ 3b ˃ 6b, while compound 5a did not show any interaction data belonging to the shaped complex with 1cca. Hence, most synthesized compounds can be used as anti-cancer and anti-oxidant agents.
Understanding Medical Cannabis: A Simple Guide to CBD and THC
Authors: Harbich Maciej Antoni , Michalak Sylwia Sulimiera , Michalak Lidia Magdalena
Published: September 2024

There is an ongoing debate in the literature about the place of cannabinoid therapy in everyday clinical practice. The overview examined systematic reviews and meta-analyses on the use of medical marijuana (MM) in specific or diseases, such as epilepsy, multiple sclerosis, pain, nausea and vomiting during chemotherapy, cachexia, and sleep disorders. We analyzed different cannabinoids like CBD, THC, dronabinol, nabilone, and THC:CBD combinations (Nabiximol) to understand their effects on various medical conditions, dose effectiveness, and side effects. CBD showed promise epilepsy, Nabilone showed a significant reduction in pain and insomnia, Nabiximol has been effective in reducing spasticity, pain, and sleep disturbance in multiple sclerosis patients. Nabilone and dronabinol improve nausea and vomiting due to chemotherapy, but the evidence is low. The results on the effectiveness of MM in the treatment of cachexia and cancer pain are inconclusive. Outcomes suggest that side effects typically were mild to moderate in severity. The type of cannabinoid (including CBD and THC content) and amount of dose, were found to potentially influence the results obtained in the trials, affecting both the effectiveness and the side effects experienced by patients. Young people, elderly, and children are particularly vulnerable and, despite ongoing research in these age groups, we still know too little about whether and in which clinical conditions the use of medical cannabis is justified. The analyzed studies faced limitations due to heterogeneity in methodology, dosages, and outcome measures and highlighting potential controversies in interpreting the results, so further research is needed.
Study on the Mechanism of Kaempferol Against Diabetic Nephropathy via NLRP3/Caspase-1 Signaling Pathway
Authors: Shen An-lu , Du Yong-Qin , Ding Hui-Min , Zhou Lan , Du Youg-Qin , Ye Min , Yin Gang
Published: September 2024

To systematically evaluate the protective effect of kaempferol (KPF) against renal injury in diabetic rats, and to explore the mechanism of KPF via the NLRP3/Caspase-1 signaling pathway. A diabetic rat model was established by high-fat diet combined with STZ induction, and the urinary levels of urinary creatinine, urinary protein and urea nitrogen were detected. HE and Masson staining were used to assess pathological changes. Western blot was used to detect the expression of NLRP3, Cleaved-Caspase1, GSDMD, and GSDMD-N, and RT-qPCR was used to detect the mRNA expression levels of NLRP3, Caspase1, and GSDMD. KPF significantly improved renal function, attenuated pathological changes, and reduced the levels of NLRP3, Cleaved-caspase1, GSDMD, and GSDMD-N protein and mRNA expressions in diabetic nephropathy (DN) rats. KPF has a protective effect against kidney injury in diabetic rats, and its mechanism may be related to the inhibition of the NLRP3/Caspase-1 signaling pathway.
Cytotoxic Activity and Evaluation of In Vitro Release of Apigenin 7-O-Glucoside From the Topical Pharmaceutical Formulation Containing Matricaria recutita L. Flower Extract
Authors: CICEK MAHMUT , AYDILEK NERIMAN , ULUSOY SEYMA , INAL Ebrar , AKBAL INAN HATICE , DAG AYDAN , CAGMAN ZEYNEP , OZSOY YILDIZ , KARTAL MURAT
Published: September 2024

The extracts from flower heads of Matricaria recutita L. have various biological effects, most notably anti-inflammatory. The most important flavonoid is apigenin, which is mostly found in the form of apigenin-7-O-glucoside. Apigenin-7-O-glucoside is assessed as a marker in Matricaria recutita L. extracts due to its anti-inflammatory effect. In this study, a new, cost-effective, and accurate HPLC-PDA method was developed and implemented for the quantification of apigenin-7-O-glucoside in liquid extracts of the flowers of Matricaria recutita L. grown in Türkiye (Bandırma/Balıkesir) and Türkiye (Arnavutköy/Istanbul) regions. The extraction solvent was ethanol 95.4% v/v (containing 0.12% sodium hydroxide, 0.22% sodium acetate). The apigenin-7-O-glucoside content of the extracts was detected. The total phenolic and flavonoid contents of the extracts were analyzed. Since the extract prepared from the herb grown in Arnavutköy/Istanbul region has higher apigenin-7-O-glycoside, total phenolic and flavonoid contents, a topical cream containing this extract was formulated. An in vitro release test was performed for apigenin-7-O-glucoside to examine the pharmaceutical quality and performance of the cream compared to the reference cream. The test cream showed a faster release than the reference product. In addition, the physicochemical stability of the test product was monitored for 90 days. It is expected to be more effective than the reference product in in vivo studies due to the faster release of the test product. The cell viability profile and apoptotic effect of the extracts and the test cream were evaluated on fibroblast (CCD-1079Sk) and melanoma (SK-MEL-28) cell lines.
Sborník nejen politicko-geografický
Authors: Hnízdo Bořek
Published: September 2024

Petr Jehlička, Jiří Tomeš, Petr Daněk /editoři/: Stát, prostor , politika. 1. vydání. Praha: Univerzita Karlova; Brno: Masarykova univerzita, 2000, 274 stran, ISBN 80-238-5566-2.
Quality Of Audit In Public Sector Organizations: Trends And Article Analysis
Authors: Vitriyan Espa  , Marsela Diaz  , Soeprajitno Raden Roro Widya Ningtyas
Published: September 2024

This study purpose to explore and analysis the "characteristics of audit quality" through two questions: 1. what are the publication trends of audit quality-themed articles based on research contributors, and 2. what are the developments in research related to audit quality up to the present. The study employs a systematic literature review using keywords that describe the article topic coverage to identify trends in audit quality characteristics. The sample consists of 26 articles from the database SCOPUS from 2011 to 2020 on audit quality. The results indicate that University Utara Malaysia's contributions dominate among institutional contributors to the articles, article contributions are predominantly from Indonesia by country, and contributions are dominated by the International Journal of Economics Research based on journal source. The final results related to audit quality show variability with appropriate testing. This research empirically contributes to the development of literature and aids in analyzing audit quality-related research.
Sharia as a New Culture System of Identity in the Post-Conlict Aceh, Indonesia
Authors: Mubarrak Husni , Zikri Awwaluz , Hanapi Agustin , Munir Badrul , Iskandar Iskandar
Published: September 2024

The research on Aceh in various fields has been conducted by many scholars so far. What is felt less of concern in academic studies is on current period of post-conflict Aceh after peace process between Free Aceh Movement and Indonesian Army since 2005. This article would like to discuss about contemporary situation, especially in the post-conflict Aceh, on what has been shifted dealing with socio-cultural in Acehnese society. However, it has been a big change and shifting within society in Aceh, particularly after sharia religious law stipulated as the main legal formal that is objected as social engineering. Why sharia is important to be studied here could be not separated from Aceh’s long history and its deep role of Islamization process to South East Asia. Beside it is used as an identity, sharia currently in Aceh has also chosen as the new culture system and as the way out of prolonged armed conflict in Aceh that has taken place for more than three decades (1976-2005). By using theory religion as a culture system, this article would like to discuss and analyze about how does sharia now in Aceh become a new culture system of identity that broadly changed Aceh and its society, not only in socio-cultural, but also any other dimensions of life in contemporary time. The findings show that sharia religious law which has been institutionalized and stipulated as the main legal formal is more being objected as social engineering projects for future oriented social transformation and being a new culture system of identity.
Exploring the inhibitory potential of hormone replacement therapy drugs on glutathione transferase P1-1
Authors: Muşdal Yaman , Mannervik Bengt
Published: September 2024

Aim: Glutathione transferase P1-1 (GST P1-1) plays a crucial role in the human phase II detoxication system and is implicated in drug resistance in certain cancer cells. Analogs of drugs used in Hormone Replacement Therapy (HRT) have been reported to exhibit inhibition of various GSTs. This study aims to investigate the inhibitory potential of several HRT drugs on GST P1-1 for the possible use of counteracting drug resistance and for other therapeutic purposes.
Materials and Methods: GST P1-1 was expressed and then purified in a single step using Nickel Sepharose affinity chromatography. Synthetic drugs that are used in HRT were screened for inhibition of GST P1-1 using 1-chloro-2,4-dinitrobenzene as the substrate. The IC50 value of the most potent compound was calculated and binding location and formation of bonds to GST P1-1 were identified through docking analysis.
Results: Screening the inhibitory effect of eight synthetic estrogenic drugs reveals that estradiol valerate is the most potent inhibitor, showing 72 ± 4% inhibition of GST P1-1. This effect is followed by estradiol cypionate 53 ± 5%, mestranol 39 ± 4%, and estradiol propionate 35 ± 2%. The most potent compound estradiol valerate has an IC50 value of 30 ± 2 μM. According to docking analysis, it binds to the H-site of the enzyme where the residues Phe9, Arg14, Val36, Trp39, Ile105, Tyr109, Pro203, Asn207, and Gln210 were within 5 Å proximity of the ligand. Estradiol valerate forms Pi-alkyl interactions with Phe9 and Val36, as well as an alkyl interaction with Ile104.
Conclusion: Estradiol valerate is a modest inhibitor for hGST P1-1, however it fits in the area of H-site of the enzyme and forms bonds with critical key residues. Understanding its binding site on the enzyme is critical for designing other inhibitors targeting GSTs or possibility for the potential use as a substrate with other GSTs.
Malignant pleural effusions: Are we better than the past?
Authors: Karcıoğlu Oğuz , Tekin Fatih , Öztürk Ebru , Önder Sevgen , Selçuk Ziya Toros
Published: September 2024

Objective: Malignant pleural effusion (MPE) is indicative of advanced-stage disease and a poor prognosis in almost all cancer types. Lung and breast cancers are the predominant malignancies causing MPE, collectively representing over 60% of the total. In recent years, cancer has become a type of chronic disease, with advancements in diagnostic tools and treatment strategies. Our objective was to assess the evolution of primary diagnoses, survival rates, and associated variables among individuals with MPE in recent years.
Materials and Methods: A retrospective search was conducted on the demographics, comorbidities, primary cancer sites, diagnostic interventions, and laboratory results of patients diagnosed with MPE between January 1, 2005, and July 30, 2018.
Results: Of the 663 patients who have MPE, the female/male ratio was 373/290. The mean age was 59.2 ± 14.0 at the time of diagnosis. The most common cancers were lung cancer (30.9%), breast cancer (23.3%), and gastrointestinal system cancers (16.62%). It was observed that the rate of MPE due to lung cancer increased gradually over the years. Initially, breast cancer constituted the most prevalent diagnosis in 28.2% of cases, whereas lung cancer rose to the top as the most prevalent in the second and third five-year periods (28.9% and 37.4%, respectively). Overall, the median survival time was 2.07 months. Kaplan-Meier analysis also revealed that survival times did not change significantly over fourteen years.
Conclusion: Advances in diagnostic methods and treatment modalities have altered the most common primary cancer causing MPE in recent years but have not contributed to survival time.
Impact of Systolic and Diastolic Blood Pressure on Cardiovascular Health Outcomes
Authors: Ranjan Ambedkar , Wankhade Toshal
Published: September 2024

Background: One well-known risk factor for cardiovascular (CV) disease that significantly raises morbidity and mortality rates globally is hypertension. Optimising treatment options requires an understanding of the distinct effects of diastolic and systolic blood pressure on CV outcomes. The study aims to examine into how the effects of both systolic hypertension (SH) and diastolic hypertension (DH) affected the frequency of major CV events, such as hemorrhagic, ischemic, and myocardial infarction (MI).
Methods: A retrospective cohort research comprising 180 patients was carried out, with automated oscillometric cuffs being used to measure blood pressure. The burdens of SH and DH, which were determined as continuous variables from weighted average blood pressure, were the main predictors. A composite of ischemic stroke, MI, or hemorrhagic stroke was the main result. Logistic regression and bivariate and multivariable Cox survival analyses were included in the statistical studies.
Results: The study population had average age of 65.4 years, with 52% males and 48% females. During the observation period, 45 composite outcome events occurred (25% incidence rate). Bivariate Cox analysis showed significant associations between SH burden (HR: 1.45, p<0.001) and diastolic hypertension burden (HR: 1.30, p=0.015) with the composite outcome. Multivariable analysis confirmed these associations, with consistent findings in logistic regression models.
Conclusion: Both SH and DH burdens are significant predictors of adverse CV outcomes. Effective management of both blood pressure components is essential for reducing the risk of ischemic stroke, MI, and hemorrhagic stroke.
Recommendations: To lower the risk of significant CV events, clinicians should monitor and treat both systolic and diastolic blood pressure in individuals with hypertension. Subsequent studies ought to investigate the underlying mechanisms of these correlations and assess the effectiveness of focused interventions.
Keywords: Hypertension, Cardiovascular Outcomes, Diastolic Blood Pressure, Systolic Blood Pressure.
Side effects of N95 and surgery respirator masks: A narrative review from a nursing perspective
Authors:   Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Ghazanfari Mohammad Javad
Published: September 2024

One of the major problems of public health is the transmission of respiratory infections in clinical care settings. Healthcare workers (HCWs) are exposed to a wide range of respiratory threats, such as severe acute respiratory syndrome (SARS), influenza A, and COVID-19. Meanwhile, personal protective equipment (PPE) especially N95 and surgical masks play a key role in preventing transmission and infection of respiratory infections in clinical settings. Despite the advantages and uses of surgical and N95 masks, these also have side effects. This literature review was conducted to examine the various side effects of surgical and N95 masks in HCWs. According to the results of this study, the side effects of surgical and N95 masks include skin, respiratory, cardiac, and neurological. In general, although the use of respiratory protection equipment is essential in HCW, the use of surgical and N95 masks adversely affects communication, physiological, and psychological abilities in HCW. In particular, it is severe in vulnerable people, such as pregnant women, and those with respiratory problems, such as chronic obstructive pulmonary disease. Therefore, there is a lack of training guidelines to improve the safety of HCWs.
The relationship between burn and schizophrenia: A narrative review from a nursing perspective
Authors:   Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Zabihi Mohammad Reza , Bastani Mahta ,   Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Akhoondian Mohammad ,   Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Published: September 2024

Recent evidence suggests a relationship between burn injuries and schizophrenia. In this study, the authors aim to explore the intersection of schizophrenia and severe burn injuries from a nursing perspective. A comprehensive search of electronic databases including PubMed, MEDLINE, PsycINFO, CINAHL, and Cochrane Library was conducted from inception to April 1, 2024. The results demonstrated that nurses play a vital role in early detection, holistic assessment, and intervention to address the emotional well-being of these patients. Key responsibilities include educating patients and families, providing emotional support, and creating a therapeutic environment. Overall, by promoting mental health engagement, implementing personalized care plans, and facilitating access to mental health services, nurses can significantly contribute to the recovery and quality of life of burn survivors with schizophrenia.
Development of Sustainable Concrete using Fly Ash and Partial Cement Replacement with Limestone
Authors: Tiwari Ashwini
Published: September 2024

This study investigates the feasibility of developing sustainable concrete using fly ash and partial cement replacement with limestone. The effects of fly ash and limestone on the workability, compressive strength, and durability of concrete are evaluated. The results show that the incorporation of fly ash and limestone improves the sustainability of concrete while maintaining its mechanical properties.
Building a dermestid colony at the Natural History Collection of the Federal University of Piauí (CHNUFPI)
Authors: Câmara Tainara , Freire-Filho Robério , Vilela Júlio Fernando
Published: September 2024

Considering the need to speed up processes to increase the osteological collection of the Natural History Collection of the Federal University of Piauí (CHNUFPI), we decided to build the first colony of Dermestes sp. and to draw up a basic protocol so that other collections can succeed in building and maintaining their own colonies. In 320 days, 19 carcasses of non-flying small mammals (Rodentia and Didelphimorphia), were completely cleaned and deposited in the CHNUFPI osteological collection. The colony proved to be efficient for cleaning small mammal carcasses, suggesting the same procedure could be applied to other similar size vertebrates.
ТРЕНІНГ ЯК ЕФЕКТИВНИЙ МЕТОД ПРАКТИЧНОЇ ПІДГОТОВКИ МАЙБУТНІХ ФАХІВЦІВ СОЦІАЛЬНОЇ СФЕРИ
Authors: ЗАХАРІНА Тетяна , ЧЕРНУХА Надія
Published: September 2024

У статті розглядаються особливості впровадження методу тренінгу в освітній процес практичної підготовки майбутніх фахівців соціальної сфери, переваги використання методу тренінгу в освітньому процесі підготовки здобувачів вищої освіти. Здійснено аналіз наукових праць з проблеми дослідження з метою вивчення ефективності методу тренінгу в процесі практичної підготовки фахівців соціальної сфери. Представлено результати дослідження, яке здійснене у формі анкетування. Результати дослідження переконують, що тренінг є ефективним методом практичної підготовки майбутніх фахівців соціальної сфери, оскільки він сприяє ефективному засвоюванню знань, розвитку практичних навичок та підвищенню рівня впевненості в собі як майбутнього фахівця соціальної сфери. Мета дослідження полягає у визначенні особливостей впровадження тренінгу як методу практичної підготовки фахівців соціальної роботи та проведення дослідження для визначення ефективності тренінгу як методу підготовки майбутніх фахівців соціальної сфери. Основними завданнями окреслено наступні: визначення особливостей впровадження тренінгу як методу практичної підготовки фахівців соціальної роботи; виявлення переваг використання методу тренінгу у практичній підготовці майбутніх фахівців соціальної сфери; проведення дослідження для виявлення ефективності тренінгу як методу підготовки майбутніх фахівців соціальної сфери. Досягнення поставленої мети та вирішення завдань дослідження було здійснено за допомогою теоретичних та емпіричних методів дослідження. У висновках підтверджено, що тренінг є ефективним методом практичної підготовки здобувачів вищої освіти спеціальності 231 «Соціальна робота» та обґрунтовано, що впровадження тренінгів в освітній процес сприяє застосуванню теоретичних знань на практиці, формуванню необхідних компетенцій для ефективної роботи в соціальній сфері та підготовці майбутніх соціальних працівників до викликів сучасного суспільства.
Pengaruh Variasi Ukuran Partikel pada Pembuatan Bio-Briket dari Pelepah dan Tandan Buah Kosong Kelapa Sawit
Authors: Syukri Muhammad , Maisarah  , Rangkuti Ika Ucha Pradifta , Rahimah  , Tama Harahap Khaidir Ali , Nurhidayat Taufik
Published: September 2024

Palm oil empty fruit bunches (EFB) and fronds are solid waste originating from palm oil processing which can be used as the main raw material for making briquettes. This is supported by its contents, namely lignin, hemicellulose and cellulose. The smaller the particle size, the greater the compressive strength of the briquette, but the burning rate will be slower because the cavity/pores of the briquette are smaller. This research aims to determine the effect of particle (mesh) size on the characteristics of briquettes which include water content, ash content, density, compressive strength and burning rate as well as to determine the best composition of a mixture of empty oil palm fruit bunches and fronds. The results of this research show that the best particle size is 70 mesh briquettes with a raw material composition of 46% EFB and 46% fronds (1:1) with 8% tapioca flour adhesive. Biobriquettes with small particle sizes have lower calorific value. The results of this research indicate that the manufacture of briquettes is in accordance with the Standard Characteristics of SNI No. 1/6235/2000.
THE IMPACT OF DIGITAL TRANSFORMATION IN UNIVERSITIES ON GLOBAL ECONOMIC DEVELOPMENT
Authors: Бобро Наталія
Published: September 2024

The article explores how the digital transformation of universities impacts economic development. Digital technologies have become an integral part of education, changing the quality of education and economic processes. By implementing digital technologies, universities not only improve educational outcomes, but also foster the creation of new industries, jobs, and global markets integration. Special attention is given to digital platforms that ensure effective interaction among teachers, students, and administrators, optimizing resource management and productivity. The economic aspects of digitalization, such as the development of new business models and the integration of economic entities into a unified information space, are also considered. The SWOT analysis highlights both the benefits of digitalization, such as transparency and accessibility of education, and the threats, such as cybersecurity challenges and infrastructure monopolization. The article concludes that digital transformation in universities drives economic growth, encourages innovation, and enhances workforce training for the global market.
КРЕАТИВНІ ТЕХНОЛОГІЇ В СУЧАСНІЙ СИСТЕМІ МЕНЕДЖМЕНТУ
Authors: Бондар Алла
Published: September 2024

В статті досліджено вплив креативних підходів на ефективність управління та конкурентоспроможність організацій, а також розроблено рекомендації щодо системного підходу до їх впровадження для підвищення адаптивності та інноваційності організацій. Обґрунтовано необхідність інтеграції креативних технологій, таких як дизайн-мислення, agile-методології, гейміфікація, VR/AR, штучний інтелект та інші, для розвитку інноваційного потенціалу організацій. Практичне значення полягає у створенні комплексу рекомендацій, спрямованих на формування корпоративної культури, що підтримує інновації, розвиток лідерських якостей та використання сучасних технологій. Зроблено висновок про важливість застосування креативних технологій для забезпечення гнучкості та довгострокового успіху організацій.
ІНФОРМАЦІЙНО-АНАЛІТИЧНЕ ЗАБЕЗПЕЧЕННЯ УПРАВЛІННЯ ФІНАНСОВО-ЕКОНОМІЧНОЮ БЕЗПЕКОЮ СУБ’ЄКТІВ ГОСПОДАРЮВАННЯ
Authors: Крамаренко Катерина , Вінниченко Олена
Published: September 2024

У статті наведено результати дослідження теоретичних основ формування інформаційно-аналітичного забезпечення системи управління фінансово-економічною безпекою суб’єктів господарювання. Проведено аналіз змісту понять «фінансово-економічна безпека», «інформаційно-аналітичне забезпечення», «обліково-аналітичне забезпечення». Розкрито особливості управління фінансово-економічною безпекою суб’єкта господарювання. Визначено роль, сутність, мету, принципи, функції, інструментарій та складові інформаційно-аналітичного забезпечення системи управління фінансово-економічною безпекою суб’єктів господарювання. Акцентовано увагу на значенні бухгалтерського обліку та доцільності застосування терміна «обліково-аналітичне забезпечення». Проаналізовано вимоги до критеріїв оцінювання ефективності інформаційно-аналітичного забезпечення управління фінансово-економічною безпекою.
ТЕОРЕТИЧНІ АСПЕКТИ ФОРМУВАННЯ ТА РЕАЛІЗАЦІЇ МАРКЕТИНГОВИХ СТРАТЕГІЙ ДЕВЕЛОПЕРСЬКИХ КОМПАНІЙ
Authors: Фісуненко Павло , Подрєз Віктор , Спиридоненков Віталій
Published: September 2024

Стаття присвячена розгляду теоретичних аспектів формування та реалізації маркетингових стратегії девелоперських компаній. Метою дослідження є виокремлення ключових теоретичних аспектів та побудова на цій основі послідовності формування та реалізації маркетингових стратегій девелоперських компаній. Встановлено, що в сучасних умовах маркетингова стратегія є одним з ключових орієнтирів в діяльності компанії, невід’ємною складовою стратегії бізнесу в цілому. Проведено аналіз наукових праць, присвячених теоретичним аспектам здійснення маркетингової діяльності, вибору маркетингових стратегій, застосуванню різних концепцій комплексу маркетингу. Розглянуто особливості елементів комплексу маркетингу в контексті їх застосування по відношенню до девелоперської компанії. Побудована послідовність формування та реалізації маркетингової стратегії девелоперської компанії, яка дозволяє не лише обрати маркетингову стратегію та визначити заходи, які їй відповідають, але й здійснити управління маркетинговою діяльністю в ході її реалізації з наступною оцінкою ефективності їхнього впровадження.
Diplomacia y revolución. Intervención, conflicto y reclamaciones entre México y Estados Unidos (1910-1923)
Authors:   Universidad de Guadalajara, Hernández Ponce Manuel Alejandro
Published: September 2024

La diplomacia va más allá de sus representantes, es una cuestión económica, social y cultural compleja que requiere un análisis minucioso de las conversaciones, negociaciones y conflictos establecidos durante periodos de crisis, como lo fue la Revolución mexicana. Esta obra analiza los diversos episodios de intervención, conflicto y reclamos que sostuvo el gobierno de Estados Unidos frente a los distintos grupos revolucionarios que tomaron el poder de 1910 a 1923. El objetivo de esta obra es analizar cómo las relaciones entre México y Estados Unidos durante los años revolucionarios fueron resultado de una interdependencia compleja, pues ninguna nación logró imponer totalmente sus intereses aun cuando existieran importantes asimetrías en su economía, sociedad y poderío militar.
Density dependence impacts our understanding of population resilience
Authors: Hernandez Christina , Stott Iain , Koons David , Salguero-Gomez Rob
Published: September 2024

Current metrics of demographic resilience (e.g., resistance, recovery) summarize the potential responses of populations to the frequent, varied disturbances that ecological systems experience. Much of the application of these metrics has focused on the potential response of time-invariant, density-independent structured population models to hypothetical disturbances. Here, we examine such resilience measures in a flexible structured model with five vital rate parameters. Making one vital rate density-dependent at a time, we show that density dependence has profound and complex impacts on our understanding of resilience. Depending on which vital rate was subject to density effects, existing measures of demographic resilience (compensation, resistance, and recovery time) either increased or decreased with population density. Moreover, the density-independent model under-predicted the recovery time of the corresponding density-dependent model, with a greater offset for species with longer generation times and higher iteroparity. Our findings demonstrate the importance of underlying non-linear processes when examining demographic resilience.
Insect Lipid Metabolism in the Presence of Symbiotic and Pathogenic Viruses and Bacteria
Authors: Visser Bertanne , Scheifler Mathilde
Published: September 2024

Insects, like most animals, have intimate interactions with microorganisms that can influence the insect host’s lipid metabolism. In this chapter, we describe what is known so far about the role prokaryotic microorganisms play in insect lipid metabolism. We start exploring microbe-insect lipid interactions focusing on endosymbionts, and more specifically the gut microbiota that has been predominantly studied in Drosophila melanogaster. We then move to an overview of the work done on the common and well-studied endosymbiont Wolbachia pipientis, also in interaction with other microbes. Taking a slightly different angle, we then look at the effect of human pathogens, including dengue and other viruses, on the lipids of mosquito vectors. We extend the work on human pathogens and include interactions with the endosymbiont Wolbachia that was identified as a natural tool to reduce the spread of mosquito-borne diseases. Research on lipid metabolism of plant disease vectors is up and coming and we end this chapter by highlighting current knowledge in the field.
Generalization of the Methodology of Analysis of Investment Processes in the Region
Authors:   Lviv University of Trade and Economics, Kutsyk Petro O. , Boiko Ruslan V. ,   Lviv University of Trade and Economics
Published: September 2024

The article updates the issue of developing a methodology for analyzing investment activity and investment development at the regional level. The aim of the study is to generalize and further develop the methodological principles of analyzing investment processes at the regional level. It is proved that the analysis of investment processes in the region gives a more complex picture regarding the volumes, dynamics, structural characteristics and efficiency of investment activities in the regional economy. In general, in order to carry out a systematic and comprehensive analysis of the processes of development of investment activity and activity in the region, it is important to form a full-fledged regulatory and methodological support, consisting of approaches, methods and tools of analysis and diagnostics, as well as a system of indicators. It is established that the results of the analysis are conclusions regarding, on the one hand, the investment activity of economic entities, and, on the other hand, the quality of the regional investment policy. It has been proven that the regulatory and methodological support for the analysis of investment processes in the region consists of two blocks: (1) microeconomic, (2) macroeconomic. It is determined that the criterion of the first block is the ease (operational, cost-effectiveness, efficiency) of passing through the stages of the investment process, while the second block is the contribution (volume, structure, quality) of investments to the socioeconomic development of the region. It is substantiated that the introduction of the system of analysis of the investment environment at the regional level involves the following procedural stages: institutionalization of the practice of analysis; formation of resource support; identification of persons responsible for the analysis; consolidation of the system of indicators prepared by official statistics bodies; forming a database of experts; development of clear regulations for surveying and evaluating the characteristics of the investment environment; determination of procedures for "reaction" of authorities to the results of the analysis, publication of the results.
Modern Problems of Financial Stability of Territories in the Context of Balanced Development
Authors:   O. M. Beketov National University of Urban Economy in Kharkiv, Muzychenko Viktoriia V.
Published: September 2024

The problem of ensuring the financial sustainability of territories is relevant in conditions of economic instability. Balanced development of territories involves the efficient use of financial resources, support for entrepreneurial activity, and stability of local budgets. This article examines the contemporary problems of financial sustainability of territories and provides recommendations for their balanced development. The aim of the article is to identify problems of financial sustainability of territories and develop recommendations for their balanced development. The study analyzes the factors influencing the financial sustainability of the territories and identifies mechanisms for increasing the financial stability of the regions. The pivotal factor is the development of small and medium-sized businesses (SMEs), which create jobs and foster economic growth. Support for SMEs includes access to finance, administrative support and skills development for entrepreneurs. The provision of credit guarantees, the development of microfinancing and the support of venture capital can increase the financial sustainability of SMEs. Simplification of business registration procedures, reduction of regulatory barriers and transparency of the tax system contribute to the development of entrepreneurial activity. It is noted that from 2021 to 2023 the number of enterprises in the Kharkiv region fluctuated due to hostilities. This has had a significant impact on economic activity and the business climate in the region. The analysis of the number of individual entrepreneurs also reflects negative trends. Many entrepreneurs were forced to close their businesses or relocate them to other regions. The hostilities have had a significant negative impact on the economic situation in the Kharkiv region, which affects the overall financial sustainability of the region. This highlights the need to support businesses to recover financial sustainability. The continuation of financial programs to support SMEs will help strengthen the financial sustainability of the region.