bluuebunny/crossref_metadata_2025 huggingface dataset:
Social vulnerability associated with sanitation and its connection to environmental injustice in the West Bank and Gaza Strip in Palestine: الضعف الاجتماعي المرتبط بالصرف الصحي واتصاله بالظلم البيئي في الضفة الغربية وقطاع غزة في فلسطين
Authors: Fuad Yousef Rammal, Bouchta Alkhazzan Fuad Yousef Rammal, Bouchta Alkhazzan
Published: March 2022

This paper aimed to discuss the concept of social vulnerability associated with sanitation and its connection to environmental injustice in a framework of governance as a new way to manage natural resources, which includes the participation of social actors in planning environmental policies, by investigating how the social vulnerability associated with sanitation and its connection to environmental injustice in the West Bank and the Gaza Strip in Palestine, and the paper analyzes cases of inequality within two axes. The first axis is based on the use of the methodology of organizing information that is carried out through bibliographic review, and the second axis is based on the statistical analysis of the relevant tables, which showed an increasing mathematical function by increasing independent variables that are closely related, noting that The results of the analysis showed a close and increasing correlation between the method of connecting wastewater to the sewage networks with poverty rates based on the area of ​​residence (rural, camp, urban). The analysis focuses on the two axes of the paper on taking into account the essential role of public policies in combating social and environmental inequalities, especially those related to the arbitrary practices of the Israeli occupation. One of the most important results of the analysis was that the social vulnerability associated with sanitation is related to environmental injustice in the West Bank and Gaza Strip, and is exacerbated by the arbitrary practices of the Israeli occupation, especially environmental ones. The paper concluded with the importance of taking into account the integration of water policies with those related to agriculture and economic works, and the inclusion of all socio-economic factors within specialized programs within the framework of partnership with institutions, including private sector institutions, to develop joint activities between them, and to prioritize safe environmental sanitation for the poor population, and areas Low-income people and those most affected by the arbitrary policies of the Israeli occupation, in addition the paper recommended the importance of establishing programs to ensure social justice, combat differences in service levels, adopt the principle of differentiation between users by imposing fees on water uses, and manage the balance between preserving resources and promoting multiple uses for them.
Philosophy of disciplinary punishment of university faculty in Syria: فلسفة العقوبة التأديبية لأعضاء هيئة التدريس في الجامعات السورية
Authors: Wayel Ahmad Almahmoud, Walid Akel Arab Wayel Ahmad Almahmoud, Walid Akel Arab
Published: March 2022

This research examines the philosophy of disciplinary punishment in terms of the definition of disciplinary punishment, the principles governing it, the types of penalties imposed by the Board of Discipline of Teaching Staff and the manner in which the Board is set up to impose disciplinary punishment on university faculty The main objective of this research is to show the extent to which these disciplinary sanctions contribute to achieving compatibility and a fair balance between the public interest that relates to the proper functioning of the education facility without harming the rights and guarantees of the faculty member in universities, as well as protecting him from the arbitrariness of the administrative authority when signing it. In this study, we followed the analytical approach to study the principles that govern disciplinary penalties and the types of these light penalties imposed by each of the university president, and severe penalties also imposed by the competent disciplinary board stipulated in the Syrian Universities Organization Law. It was concluded that the Syrian Universities Organizing Law specified disciplinary penalties for faculty members exclusively, and the Syrian legislator did not specify disciplinary violations exclusively in the Universities Organizing Law, and did not link each disciplinary violation with the disciplinary punishment ensuing from it, but left the assessment of this to the competent disciplinary authority and we recommend the Syrian legislator Determining a specific disciplinary penalty for each disciplinary violation, in order to protect the faculty member from the arbitrariness of the administrative authority in imposing penalties, although it is difficult to identify all violations, due to their large number and differences.
Requirements for Applying The STEM Approach in Teaching Mathematics from The Point of View of Public School Teachers in Ajloun Governorate: متطلبات تطبيق منحى STEM في تدريس الرياضيات من وجهة نظر معلمي المدارس الحكومية في محافظة عجلون
Authors: Ibrahim Mohamd Yousef Almomani Ibrahim Mohamd Yousef Almomani
Published: March 2022

This Study aimed to identify the requirements for applying the STEM approach in teaching Mathematics from the point of view of public school teachers in Ajloun Governorate, the researcher used the Descriptive approaches, study Sample consisted from (650) Female and male mathematics teacher, chosen randomly, to collect data Questioner used, which consisted (33) paragraph divided to three sector, the result of SPSS analysis shown that the degree of the requirements for applying the STEM approach in teaching Mathematics from the point of view of public school teachers in Ajloun Governorate was moderated with average (3.60 out of 5) , the requirements related to the teacher got the highest average (3.70) with a grade of (high), then the requirements related to the educational content with an average of (3.57) and finally the requirements related to the educational environment with an average of (3.54) and both rated (medium) The finding also showed there is no statistically significant differences at (α≤0.05) refers to teacher sex (male and female) in addition there were statistically significant differences refers to teacher qualification in favor of (High educating). Based on the results, the researcher presented a number of recommendations and proposals to provide the necessary requirements and conduct complementary studies on the subject.
The Role of E-Management in Improving the Crowd Management from the Perspective of the Employees in the Hajj and Umrah System: دور الإدارة الإلكترونية في تحسين إدارة الحشود من وجهة نظر العاملين في منظومة الحج والعمرة
Authors: Donya Abdel-Aziz Ayyad Donya Abdel-Aziz Ayyad
Published: March 2022

This descriptive study aimed to identify the role of the e-management at improving the crowd management of the Hajj Operations: e-planning, e-organizing, e-guidance, and e-monitoring) from the perspective of the employees in the Hajj. The study included (n = 250) of the employees in the Hajj and the Rahman guests who responded to the survey. The findings indicated that the practice of e-administration by the employees in the Hajj was high. The electronic crowd monitoring appeared with the highest average of (3.62). The degree of e-administration improvement for the crowd management, was high, with average (4.40). The part of electronic organizing in crowd management was found to be the highest, with an average of (4.43). Moreover, the study showed a statistically significant correlation between the degree of employees' practices of the Hajj, the e-administration, and all the areas of improvement in the crowd managements, at the level of significance (α ≤ 0.01). Finally, the satisfaction level of the Rahman guests about the crowd management was significantly high, with average (4.33). The study suggested increasing the attending of the technical courses for the employees in the Hajj, and providing free internet in the holy sites during the seasons of Hajj. Moreover, the study recommended conducting a study on the application of e-administration in the field of Umrah, and conducting a study on crowd management in the Prophet's Mosque in Madinah.
Didactic of the Hadith lesson in e-learning and the quality question; An analytical descriptive study of a case in higher education in Morocco: ديداكتيك الدرس الحديثي في التعليم الإلكتروني وسؤال الجودة؛ دراسة وصفية تحليلية لحالة التعليم الجامعي بالمغرب
Authors: Zineb Abouali Zineb Abouali
Published: March 2022

The study aimed at revealing the modern didactical methods, provided by e-learning, through the Digital platform of the University in Casablanca, taking into account the level of educational environment in all its components, to achieve quality in the outputs of Hadith lesson, through e-learning. The researcher used the descriptive approach for the teaching situation of Hadith at Casablanca University, based on the observation of theoretical lessons experience for two semesters across the digital platform, which is used by reference documents on e-learning mentioned in the latest review index. The research came in an introduction to the overall framework on the digital platform, the importance of the subject, objectives and previous studies on the subject, problematic and asking questions, followed to indicate the terms of the study, and then stages of the preparation and achievement of Hadith lesson On the digital platform for its specificities imposed by the quality of the digital education approved, and then the challenges of e-learning and its hats that may hinder the quality aspired by higher education. The study concluded that progress in digital university teaching in the Hadith lesson requires attention to the modern didactical methods, which guarantee the quality of outputs. According to the results, the researcher submitted recommendations: confirmed the importance of using the latest Didactical teaching methods and modern technologies in the Hadith lesson, and to conduct supplementary studies on the subject.
Academic Problems among Students with SLD and its Relationship to Teachers' Attitudes toward the Use of Assistive Technologies: المشكلات الأكاديمية لدى الطلبة ذوي اضطرابات التعلم المحددة وعلاقتها باتجاهات المعلمين نحو استخدام التقنيات المساندة
Authors: Nabil Salah Hemedan, Iman Joudeh, Noura Joudeh Nabil Salah Hemedan, Iman Joudeh, Noura Joudeh
Published: March 2022

This study aimed to identify the academic problems among students with SLD and its relationship to teacher’s attitudes towards the use of assistive technologies in Amman. To achieve the objectives of the study, the researcher followed the correlative descriptive approach by developing two tools, the scale of teacher’s attitudes towards the use of supportive techniques, and the scale for estimating academic problems. A simple random sample of the respondents was drawn (44%) of the study population of (250) teachers, and thus the volume of The study sample is (110) male and female teachers in the learning resource rooms in public and private schools for the academic year (20/21), and the study reached a set of results, the most prominent of which were: The level of teacher’s attitudes towards the use of supportive technologies in teaching came with an arithmetic average of (3.30) and at an average rating level, The results showed that the level of academic problems of students with SLD (reading, writing, and arithmetic) was generally average depending on their total arithmetic mean, which amounted to (3.61), and the results also showed a correlation between teachers' attitudes towards using supportive techniques and reducing academic problems. For students with SLD. The study recommended the necessity of holding workshops and specialized training programs for teachers of learning resource rooms in order to increase their efficiency in dealing with various supportive technology tools to make the most of the advantages.
Psychological stress and its relationship to behavioral deviation in light of the Corona pandemic from the point of view of workers in government hospitals in Jordan: الضغوط النفسية وعلاقتها بالانحراف السلوكي في ظل جائحة كورونا من وجهة نظر العاملين في المستشفيات الحكومية في الأردن
Authors: Reem Mahmoud Al-Rawashdeh Reem Mahmoud Al-Rawashdeh
Published: March 2022

The aim of the research is to reveal the relationship between psychological stress and behavioral deviation in light of the Corona pandemic from the point of view of workers in government hospitals in Jordan. To achieve the objectives of the research and data collection, a questionnaire was used as a data collection tool, and the descriptive analytical correlative approach was used, and the study sample consisted of (294) male and female workers in government hospitals in Jordan. The results of the research showed that the level of psychological stress in light of the Corona pandemic from the point of view of workers in government hospitals in Jordan was average, and that the level of behavioral deviation from the point of view of workers in government hospitals in Jordan was also moderate, and the results also showed a positive correlation with statistical significance. Between psychological stress and behavioral deviation in light of the Corona pandemic from the point of view of workers in government hospitals in Jordan. And there were no differences in the perceptions of the study sample members towards the relationship of psychological stress in behavioral deviation due to demographic variables (sex, experience, and place of residence). Based on these results, the researcher recommended the need for state agencies to study the precautionary measures they take due to the Corona pandemic before applying them, knowing their impact on members of society, relieving psychological pressures on them, and constantly evaluating those measures.
The organizational period in the Jordanian employment contract: المدة التنظيمية في عقد العمل الأردني
Authors: Kutibah Hamid Al-Harazneh, Mohammad Fawwaz Al-Maaitah, Othma Kutibah Hamid Al-Harazneh, Mohammad Fawwaz Al-Maaitah, Othma
Published: March 2022

The study aimed to demonstrate the importance of the organizational periods and the domain of applying them in the Jordanian employment law, especially that the law didn't address the concept of organizational period and didn't show the periods that are considered within organizational periods within the Jordanian employment law. The study used the analytical descriptive approach, where the study investigated the legal laws and the courts' rules relevant to the study topic. The organizational period in the Jordanian employment contract refers to the period mentioned by the Jordanian legislator and forced individuals to apply it according to certain rules. The researchers addressed the organizational period in the Jordanian employment contract by dividing the study into two topics, where the first topic addressed the extent to which the periods of individual work contract are considered as valid from the organizational periods. The study demonstrated the meaning of limited-time individual employment contract and the non limited-time employment contract and then demonstrated the difference between them. In the second topic, the researchers discussed the period of judging the urgent cases and illustrated the extent to which they are considered within the organizational periods.  The researchers concluded with a number of results and recommendations, including that the non limited-time contracts imply that the party intending to terminate the contract should inform the other party within a period of one month at least, and the Jordanian employment law stated that the magistrate Court should adjudicate the employment disputes within no more than three months. The study recommended the necessity of urging the Jordanian legislator to amend the Jordanian employment law No. 8 of 1996 by determining the time period during which the limited-time employment contract is valid in order to consider it within the organizational period, since the Jordanian legislator stated in the Jordanian civil law No. 43 of 1976. The study also recommended that the Jordanian legislator should determine a certain period of time for litigation before the authority of rents and organize that in a legal way to ensure implementing it in the right way.
The Degree of Ajloun Governorate School Principals Practice of Educational Leadership standers from teacher perspective: درجة ممارسة مديري المدارس الحكومية في محافظة عجلون لمعايير القيادة التعليمية من وجهة نظر المعلمين
Authors: Mohammad Mahmoud AbdAllah AlGharibeh Mohammad Mahmoud AbdAllah AlGharibeh
Published: March 2022

This study aimed to identify the degree of Ajloun Governorate school principals practice of educational leadership standers from teacher perspective, the researcher used the Descriptive approaches, to collect data Questioner used, which consisted (33) paragraph Divided to five sector It was applied to an intentional sample of (430) male and female teachers. The results showed that the degree of public school principals’ practice of educational leadership standards from the teachers’ point of view obtained a total arithmetic mean (3.79 out of 5), that is, with a (high) degree of practice at the level of the five domains; The field of decision-making obtained the highest average (4.00), followed by the field of promoting community partnership with an average (3.93), thirdly, the field of human and material resources management with an average (3.92), all with a degree of practice (high), and fourthly, the field of promoting student learning with an average (3.67) and finally planning and evaluation with an average ( 3.43 and these two have a degree of practice (medium)The finding also showed there is no statistically significant differences at (α≤0.05) refers to teacher sex (male and female) in addition there were statistically significant differences between the teacher years of experience in favor of (9 years and more).
The difficulties that secondary school teachers face in using electronic learning platforms in Yanbu Governorate, Kingdom of Saudi Arabia: الصعوبات التي تواجه معلمي المرحلة الثانوية في استخدام منصات التعليم الإلكترونية في محافظة ينبع بالمملكة العربية السعودية
Authors: Noof Mohammed Al-Rifai, Areej Hamza Al-Sisi Noof Mohammed Al-Rifai, Areej Hamza Al-Sisi
Published: March 2022

This study aimed to identify the difficulties that secondary school teachers face in using electronic learning platforms in Yanbu Governorate, Kingdom of Saudi Arabia, and the extent to which these difficulties differ in light of some variables. 1686) male and female teachers, and to collect data, the questionnaire was designed as a tool for the study, so that the questionnaire was applied to an intentional sample of (320) from the study population. ) with a percentage of (67.6%), followed by the dimension of technical difficulties faced by teachers at electronic education platforms at a medium degree, where the arithmetic average reached (3.38), and finally came the dimension of the skill difficulties that teachers face in using electronic education platforms, and its content ranked last with an arithmetic average of ( 3.14 with a percentage of (62.8)%. The results also indicated that there were no statistically significant differences due to the variable (gender, level of technical expertise, number of Training courses (on the skill difficulties that teachers face in using e-learning platforms and their content, technical difficulties that teachers face when using e-learning platforms, and the results indicated that there are statistically significant differences due to the variable (level of technical expertise, number of training courses) about difficulties related to ease of use E-learning platforms and their perceived benefit.
Spatial Cognition and its Relationship to Temporal Cognition among preschool children in Aleppo City: الإدراك المكاني وعلاقته بالإدراك الزماني لدى أطفال ما قبل سن المدرسة في مدينة حلب
Authors: Yara Barakat Albader, Muhammad Qasim Abdullah Yara Barakat Albader, Muhammad Qasim Abdullah
Published: March 2022

The aim of the research is to study the relationship between Spatial Cognition and Temporal Cognition among pre- school children in Aleppo Governorate in Syria, in addition to studying the differences between spatial cognition and temporal cognition according to the gender variable. The research sample consisted of (50) boys and girls between the ages of (3- 6) years. Two tests were used: The Spatial Cognition test and the Temporal Cognition test prepared by the researchers. The study reached the following results: 1) There is a statistically significant relationship between spatial cognition and temporal cognition among pre- school children, 2) There are differences between males and females in spatial cognition in favor of females, 3) There are differences between males and females in temporal cognition in favor of females.
The extent to which Islamic education courses at the secondary level incorporate the dimensions of intellectual security in the Kingdom of Saudi Arabia: مدى تضمين مقررات التربية الإسلامية في المرحلة الثانوية بالمملكة العربية السعودية لأبعاد الأمن الفكري
Authors: Mesfer Saad Mesfer Al- Shahrani Mesfer Saad Mesfer Al- Shahrani
Published: March 2022

The objective of the research is to know the extent to which Islamic education courses include the following dimensions of intellectual security: Religious dimension, national dimension, social dimension, after dialogue and acceptance of opinions, after positive thinking (critical thinking), and to achieve this goal the researcher used the descriptive approach based on the method of content analysis, the researcher also designed the study tool that consisted of the content analysis card, the research sample was determined in the book Hadith 1 course for high school students (curriculum system) in to: there is a disparity in the degree of inclusion of dimensions of intellectual security in the course of Hadith 1 for high school students, where it came in the following order: in the first degree the religious dimension by the percentage of repetitions reached (13,002%) to the total content of the course, in the second degree the social dimension by the percentage of repetitions reached (10%) to the total content of the course, in the third degree the national dimension by the percentage of repetitions reached (5%) to the total content of the course, in the fourth: Review the content planning of Hadith course 1 for high school students (courses system), in a way that allows in achieving parity and balance between the depth of content and its organization, in including the dimensions of intellectual security and distribution in an appropriate manner among its subjects, in addition to including the activities of the content of the course on the dimensions of intellectual security.
The most important problems facing municipal councils and the methods of solving them: أهم المشكلات التي تواجه المجالس البلدية والوسائل الكفيلة بحلها
Authors: Ammar Youssef Muhammad Shamayleh Ammar Youssef Muhammad Shamayleh
Published: March 2022

This study aimed at demonstrating the most important problems facing municipal councils and the methods of solving them by using the analytical descriptive approach through which the researcher addressed the most important problems facing municipal councils and the methods of solving them، such as rehabilitating the human resources in municipalities and activating surveillance over the municipal councils to enhance their relationship with citizens. The results revealed that some municipalities suffer from a lack in financial resources which، in turn، results in a delay in providing service to citizens as required، in addition to the municipal councils' need for trained and qualified staff، who receive training for the newest methods. The study concluded with a number of recommendations، as follows: The municipal councils have to increase their financial resources by getting their due funding from citizens and activate the role of collectors in obtaining taxes and fees. And Rehabilitating the human staff in municipalities and promoting the level of employees in municipalities. Enhancing the relationship between municipalities and local citizens through popular dialogue and giving citizens the opportunity to participate in the activities of the municipal councils. Enhancing the developmental role by establishing developmental projects that benefit municipalities and local community.
Evaluating the reality of total quality management in the Hajj and Umrah: تقييم واقع إدارة الجودة الشاملة في منظومة الحج والعمرة بالتطبيق على مؤسسات التموين والإعاشة بمكة المكرمة
Authors: Hasan Siraj Rawas Hasan Siraj Rawas
Published: March 2022

The study aimed to identify the reality of total quality management in catering and subsistence establishments in Makkah from the point of view of administrators and workers. The researcher used the descriptive analytical approach, and the study population was represented by the 115 kitchens in Makkah Al-Mukarramah, and the study sample was chosen from workers and administrators in those kitchens. The researcher has come to many findings, the most important are: The catering and catering establishments in Makkah implement Total Quality Management.The senior management of catering establishments is committed to the success of total quality management. In the light of these results, the researcher recommended: The need for the higher management of the catering institutions in Makkah to provide all the necessary resources for the appropriate development and continuous improvement of their systems. The necessity of involving workers in the strategic planning process.
Personal Digital Health Assistants
Authors:   Department of Anesthesiology, San Mateo Medical Center, San Mateo, California, USA, U Jain
Published: March 2022

Personal Digital Health Assistants (PDHA) are applications that can run on a computer or mobile device. They acquires, stores, and analyzes health information and communicate with remote servers. They are utilized by patients or their caregivers. Many systems are available.
Psoriasis Exacerbation Following COVID-19 Mrna Vaccination in an Elderly Patient
Authors:   Medical Faculty, Ulm University, Germany, MV Gatzka , P Czech ,   Histology Laboratory Laaf, Freiburg, Germany, WJ Czech ,   Department of Dermatology, Freiburg University, Germany
Published: March 2022

Psoriasis is a chronic recurrent inflammatory disease of the skin and joints mediated by different subsets of T-cells and other immune cells. Known trigger factors of psoriasis include bacterial, viral and fungal infections, various drugs, stress, and mechanic irritation. Onset of psoriasis post vaccination for influenza, tuberculosis and pneumococcal pneumonia has been observed, but the exact mechanisms are still unclear. We herein report of an elderly patient with a history of mild to moderate psoriasis episodes in the past years experiencing a severe generalized psoriasis flare-up two weeks after the second dose of a COVID-19 mRNA vaccination with Corminaty (bnt162b2 biontech/pfizer) had been administered. In the light of current data on psoriasis onset in context with COVID-19, potential molecular psoriasis trigger factors and disease mechanisms are briefly reviewed.
The Effect of Ultrasonic Instrumentation on Finish Line Integrity
Authors:   Department of Prosthodontics, The Hebrew University– Hadassah School of Dental Medicine, PO Box 12272, Jerusalem 91120, Israel, I Sher , E Sharon ,   Department of Prosthodontics, The Hebrew University– Hadassah School of Dental Medicine, PO Box 12272, Jerusalem 91120, Israel, A Hendler ,   Department of Prosthodontics, The Hebrew University– Hadassah School of Dental Medicine, PO Box 12272, Jerusalem 91120, Israel, G Ben-Gal ,   Department of Prosthodontics, The Hebrew University– Hadassah School of Dental Medicine, PO Box 12272, Jerusalem 91120, Israel, N Beytha ,   Department of Prosthodontics, The Hebrew University– Hadassah School of Dental Medicine, PO Box 12272, Jerusalem 91120, Israel
Published: March 2022

Purpose: Ultrasonic scaler is frequently used for temporary cement remnants removal from abutment teeth. A major concern is the alteration of the structural integrity of the abutment finishing line by the ultrasonic scaler. The current study evaluates the influence of ultrasonic scaling on the integrity of the finish line. The effect of finish line design (chamfer or feather edge), and its location (dentin or enamel) was also evaluated. Methods: Intact 22 human extracted molars were divided into 2 groups: finish line was prepared on enamel (n=11) and dentin (n=11), and further subdivided to finish line configuration groups (chamfer or knife-edge). Preparation of finish line was preformed following a standard repetitive procedure. 3D scans of the same tooth before and after ultrasonic instrumentation were performed. Pre and post scaling images were superimposed. The finish line alterations were evaluated and measured. The significance of the differences was evaluated using Students’ t-test. Results: The average alteration at the finish line area following ultrasonic scaling was 71.5 ± 24.6 μm. Higher alterations were found for enamel and for chamfer finish lines compared to dentin and knife edge, 134.4 ± 61.4 μm and 30.3 ±11.7 μm respectively. The highest change (228.6μm) was found for chamfer finish line located on enamel. The differences between groups were statistically significant (p<0.05). Conclusion: Ultrasonic scaling alters the topography of the finish line area of abutment teeth and thus may compromise marginal fit and integrity of the final restoration.
Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation
Authors: Hsu Wei-Tse , Ramirez Dominique , Sammakia Tarek , Tan Zhongping , Shirts Michael
Published: March 2022

Insulin has been commonly adopted as a peptide drug to treat diabetes given its ability to facilitate the uptake of glucose from the blood. The development of oral insulin remains elusive over decades owing to its susceptibility to the enzymes in the gastrointestinal tract and poor permeability through the intestinal epithelium upon dimerization. Recent experimental studies have revealed that certain O-linked glycosylation patterns could enhance insulin’s proteolytic stability and reduce its dimerization propensity, but the understanding of such phenomena at the molecular level is still evasive. To address this challenge, we propose and test several structural determinants that could potentially in uence insulin’s proteolytic stability and dimerization propensity. We used these as the metrics to assess the properties of interest from 10  s aggregate molecular dynamics of each of 12 targeted insulin glyco-variants from multiple wild-type crystal structures. We found that glycan-involved hydrogen bonds and glycan-dimer occlusion were useful metrics predicting the proteolytic stability and dimerization propensity of insulin, as was in part the solvent accessible surface area of proteolytic sites, while other plausible metrics were not generally predictive. This work helps better explain how O-linked glycosylation in uences the proteolytic stability and monomeric propensity of insulin, illuminating a path towards rational molecular design of insulin glycoforms.
Resonance between dithiocarbamates and thioureide mesomeres coupled to metal−hydrogen anagostic bond transforming under pressure
Authors: Sobczak Szymon , Roszak Kinga , Katrusiak Andrzej
Published: March 2022

The pressure-induced transformation of plane-square complex nickel(II) bis(N,N-diethyldithiocarbamate) between its soft dithiocarbamate (form I) and thioureide (form II) mesomeres is coupled to the interchange of anagostic Ni‧‧‧H−C interactions from methylene to the methyl group, respectively. At 1.23 GPa, the clearly visible giant anomalous compressibility of the crystal reveals a potential-energy difference of 5.4 kJmol-1 between the two complex forms. The structural and spectroscopic results, which are supported by quantum-mechanical calculations, connect this solid-state phase transition with the mesomeric transition, and this is accompanied by the conformational transformation of anagostic Ni‧‧‧H−C rearrangement and formation of the charge–assisted S-‧‧‧H−C bond under pressure.
Adaptive Steered Path Integral Molecular Dynamics
Authors: Sun Zhaoxi , Gong Zhihao
Published: March 2022

Steered molecular dynamics as an alternative to equilibrium techniques for enhanced sampling is receiving attention in recent years. In stratified pulling simulations, the selection criterion idea in adaptive steered molecular dynamics (ASMD) can be used to avoid the short equilibrium sampling for initial configurations in each pulling segment to some extent. In this work, we formulate the path integral (PI) realization of the ASMD algorithm to capture nuclear quantum effects via adaptive nonequilibrium pulling. Illustrative calculations in three examples including the double-well ammonia inversion, intra-molecular single-proton transfer in malonaldehyde and inter-molecular double-proton transfer in a formamidine dimer reflect the promising performance of the AS-PIMD technique for efficient calculation of free energy landscapes in practical situations where nuclear quantum effects are significant.
INAQS, a generic interface for non-adiabatic QM/MM dynamics: Design, implementation, and validation for GROMACS/Q-CHEM simulations
Authors: Cofer-Shabica Vale , Menger Maximilian , Ou Qi , Shao Yihan , Subotnik Joseph , Faraji Shirin
Published: March 2022

The accurate description of large molecular systems in complex environments remains an ongoing challenge for the field of computational chemistry. This problem is even more pronounced for photo-induced processes, as multiple excited electronic states and their corresponding non-adiabatic couplings must be taken into account. Multiscale approaches such as hybrid quantum mechanics/molecular mechanics (QM/MM) offer a balanced compromise between accuracy and computational burden. Here, we introduce an open-source software package (INAQS) for non-adiabatic QM/MM simulations that bridges the sampling capabilities of the GROMACS MD package and the excited-state infrastructure of the Q-CHEM electronic structure software. The interface is simple and can be adapted easily to other MD codes. The code supports a variety of different trajectory based molecular dynamics, ranging from Born-Oppenheimer to surface hopping dynamics. To illustrate the power of this combination, we simulate electronic absorption spectra, free energy surfaces along a reaction coordinate, and the excited state dynamics of 1,3-cyclohexadiene in solution.
Active Template Strategy for the Preparation of Interlocked Nanocarbons
Authors: May James , Van Raden Jeff , Maust Ruth , Zakharov Lev , Jasti Ramesh
Published: March 2022

Mechanically interlocked carbon nanostructures represent a relatively unexplored frontier in carbon nanoscience due to the difficulty in preparing these unusual topological materials. Here we illustrate an active template method in which the key mechanical bond forming step is accomplished by leveraging unique ligand motifs to catalyze a cross-coupling reaction within the pore of a macrocycle. Once the mechanical bond has been formed, these macrocyclic ligands can then be converted into pi-conjugated structures in a subsequent synthetic step. This method provides a general strategy by which a variety of mechanically interlocked carbon nanostructures can be prepared which will enable structure-property relationships to be established for this emerging class of nanomaterials.
Hollow cathode discharge ionization mass spectrometry: detection, quantification and gas phase ion-molecule reactions of explosives and related compounds
Authors: Hong Huanhuan , Habib Ahsan , Bi Lei , Qais Deepro , Wen Luhong
Published: March 2022

Mass spectrometry (MS) has become an essential analytical method in every sector of science and technology. Because of its unique ability to provide direct molecular structure information on analytes, an extra method is rarely required. This review describes fabrication of a variable-pressure hollow cathode discharge (HCD) ion source for MS in detection, quantification and investigation of gas-phase ion molecule reactions of explosives and related compounds using air as a carrier gas. The HCD ion source has been designed in such a way that by altering the ion source pressures, the system can generate both HCD and conventional GD. This design enables for the selective detection and quantification of explosives at trace to ultra-trace levels. The pressure-dependent HCD ion source has also been used to investigate ion-molecule reactions in the gas phase of explosives and related compounds. The mechanism of ion formation in explosive reactions is also discussed.
AGO1 regulates pericentromeric regions in mouse embryonic stem cells
Authors: Müller Madlen , Fäh Tara , Schaefer Moritz , Hermes Victoria , Luitz Janina , Stalder Patrick , Arora Rajika , Ngondo Richard Patryk , Ciaudo Constance
Published: March 2022

Argonaute proteins (AGOs), which play an essential role in cytosolic post-transcriptional gene silencing, have been also reported to function in nuclear processes like transcriptional activation or repression, alternative splicing and, chromatin organization. As most of these studies have been conducted in human cancer cell lines, the relevance of AGOs nuclear functions in the context of mouse early embryonic development remains uninvestigated. Here, we examined a possible role of the AGO1 protein on the distribution of constitutive heterochromatin in mouse embryonic stem cells (mESCs). We observed a specific redistribution of the repressive histone mark H3K9me3 and the heterochromatin protein HP1α, away from pericentromeric regions upon Ago1 depletion. Furthermore, we demonstrated that major satellite transcripts are strongly up-regulated in Ago1_KO mESCs and that their levels are partially restored upon AGO1 rescue. We also observed a similar redistribution of H3K9me3 and HP1α in Drosha_KO mESCs, suggesting a role for microRNAs (miRNAs) in the regulation of heterochromatin distribution in mESCs. Finally, we showed that specific miRNAs with complementarity to major satellites can partially regulate the expression of these transcripts.
FACTORS AFFECTING THE DELAY OF THE LONG SEGMENT SCHEME ROAD MAINTENANCE PROJECT IN CENTRAL SULAWESI PROVINCE
Authors: Rauf Lasappe , Kamaludin Tutang , Setiawan Arief
Published: March 2022

Road maintenance is a road handling activity in the form of prevention, maintenance, and repair so that it continues to function optimally to serve traffic. The long segment road maintenance scheme is divided into effective and non-effective scopes. The effective scope of the implementation period is determined by the specific terms of the contract, and the non-effective scope ends December 31 of the current year. Implementation control is determined in the schedule. The project is considered critical if it is minus (-10%) for period I and minus (-5%) for period II. If it is critical, control is carried out by conducting a Show Cause Meeting (SCM). The non-effective scope applies performance indicators (IK) in the first 90 days. Financial sanctions are imposed on service providers if minus (-5%) is in the critical (late) category. The purpose of this study is to determine the factors that have a positive and significant effect on project delays. The method used is descriptive quantitative analysis method and Smart PLS version 3 analysis tool, with a sample size of 82 respondents. The results of the study (T-statistics), human resource factor (0.161), financial factor (3.400), material factor (0.024), equipment factor (2.097), and implementation method factor (2.144), had a significant effect if T-statistic > 1, 96, the dependent variable is the delay in the long segment scheme project in Central Sulawesi Province.
Visual arts in ECE: Strengthening intentional teaching through a network professional learning community
Authors:   , Denee Rachel
Published: March 2022

Over the past 100 years, educationalists such as Dewey and Eisner have proposed radical and progressive ways in which visual art can support and enrich learning in education (Lindsay, 2016b). The early childhood pedagogy of Reggio Emilia, in Italy, is a renowned example of how teachers take an active role in facilitating children’s artistic abilities with positive outcomes for children’s learning (Gandini et al., 2005). However, in New Zealand (NZ) early childhood education (ECE), visual arts teaching for young children is still enacted within a largely developmental frame, using a hands-off approach (Terreni, 2017). According to Lindsay (2021) and Smyth (2017), teachers’ self-efficacy beliefs, knowledge and skills in art education need to be addressed in order to shift practice. Professional learning communities (PLCs) offer the potential to challenge teachers’ assumptions and beliefs and to foster transformative learning, resulting in observable shifts in art teaching practice (Damjanovic & Blank, 2017; Servage, 2008). This mixed methods study (Johnson & Christensen, 2019) within an interpretivist paradigm (Schwandt, 1994), examined the perceptions and practices of NZ ECE teachers about art education through a nationwide survey and a professional learning intervention using a network PLC approach. Situated and social cognitive theories, socio-cultural theory and transformative learning theory were interlinked in a bricolage approach (Tobin, 2018) to form a theoretical lens for this study. The first stage of the research involved a survey of ECE teachers regarding practices and perceptions about visual arts, and this provided a background context for the PLC project. Key survey findings included a dominant developmentalist view of children’s art learning amongst ECE teachers and confusion about the role of the teacher. In the embedded case study, a network PLC was established with seven teachers from four ECE services, meeting over 9 months with a mixture of practical and reflective learning about visual arts. The data collection included multiple sources for rich analysis: interviews; reflective writing; meeting dialogue; photographs; and learning story assessment documentation. Case study findings included the value of reflective and practical learning for visual arts teaching, the impact of a network PLC on the practice and perceptions of both the participants and their colleagues, the critical place of teacher self-efficacy in visual arts teaching practice, and the importance of leadership of various actors across the network to support the application and sharing of new learning. Overall, the outcomes of this study have important implications for visual arts pedagogy in ECE and effective professional learning approaches for teachers.
Crustal Structure of Wanganui Basin: Implications for Back-Arc Basin Formation
Authors:   , Tozer Brook
Published: March 2022

Onshore-offshore and onshore wide-angle reflection and refraction
seismic data are analysed in order to constrain the crustal P-wave
velocity structure within Wanganui Basin and the southern Hikurangi
margin, western North Island, New Zealand. Two, two-dimensional, P-wave
velocity models are constructed using reflection and refraction phase
travel-times based on forty-four onshore-offshore receiver gathers,
twelve onshore shot gathers and two marine multi-channel-seismic
reflection profiles collected along two transects within Wanganui Basin.
The profiles are orientated both sub-parallel and perpendicular to the
strike of the Hikurangi margin.
Red Zone as Green Corridor: Opportunities for Suburban Intensification: A Christchurch Case Study
Authors:   , Constable Sacha Therese
Published: March 2022

It is well established that urban green areas provide a wide range of social, aesthetic, environmental and economic benefits. The importance of urban green spaces has been known for decades; however the relationship between urban livability and green areas, as incorporated in overall urban green structure, has become the focus of international studies during the last 10 to 15 years. The spatial structure of green space systems has important consequences for urban form; configuring urban resources, controlling urban size, improving ecological quality of urban areas and preventing or mitigating natural disasters. However, in the field of architecture or urban design, very little work has been done to investigate the potential for built form to define and differentiate the edge to a green corridor ... This thesis therefore poses the hypothesis that architecture and urban design critically mediate between city and green corridor, through intensification and definition of the built edge, as a means of contributing to an ecological city form.
Nilai-Nilai Karakter dalam Lirik Lagu Jereh Bu Guru dari Daerah Serang Banten
Authors: Rizal Syamsul
Published: March 2022

Abstrak : Lagu jereh bu guru adalah salah satu lagu daerah yang ada di Kota Serang Provinsi Banten dengan menggunakan lirik bahasa daerah Jawa Serang (Jaseng). Lirik lagu tersebut memilki perbedan bahasa dan dialek dengan lirik lagu yang lain, sehingga menarik untuk diteliti secara mendalam. Tujuan dari penelitian ini untuk membedah dan memaknai nilai-nilai karakter apa saja yang ada di dalam lirik lagu jereh bu guru. Penelitian ini menggunakan pendekatan kualitatif. Teknik pengumpulan data dalam penelitian ini adalah observasi, wawancara, dan dokumentasi. Hasil penelitian ini menunjukan bahwa nilai-nilai karakter dalam lirik lagu jereh bu guru terdiri dari nilai religius, disiplin, rasa ingin tahu, peduli sosial, dan tanggung jawab.

Kata kunci: nilai karakter, jereh bu guru, lirik
Internal Flow Field Analysis of Twin-Screw Compressor Based on Three-Dimensional Numerical Simulation
Authors:   Biwen Chen1*, Changsheng Chen1, Zhenlai Ma1, Ji Wu1, Guoping Li1, Qiang Wang1, Yang Wo2
Published: March 2022

Twin-screw compressor is a kind of rotary positive displacement pump with excellent performance. Due to its advantages of reliable operation, high efficiency, low noise and multiphase mixed transportation, it has been widely used in the fields of energy power, biomedicine, refrigeration and air conditioning, petrochemical industry, industrial construction and other rudder fields. In recent decades, although the study of screw compressor is more in-depth, but the three-dimensional flow field simulation design of twin screw compressor still needs breakthrough. In this paper, 3d flow characteristics of twin screw compressor are studied based on CFD numerical simulation. In this paper, CFD software is used for numerical simulation of twin screw compressor, and the distribution of pressure cloud, temperature cloud and velocity cloud of internal flow field is obtained.