bluuebunny/crossref_metadata_2025 huggingface dataset:
Lactic Acid Bacteria in Vinegar Fermentation: Diversity, Functionality and Health Benefits
Authors: Hosseini Elahe , Tsegay Zenebe Tadesse , Smaoui Slim , Varzakas Theodoros
Published: February 2025

Lactic acid bacteria (LAB) play a pivotal role in vinegar fermentation, contributing significantly to its functional and sensory qualities. This review examines the microbial diversity of Lactic Acid Bacteria (LAB) in vinegar fermentation, focusing on their specific metabolic contributions and the bioactive compounds they produce, which contribute to vinegar’s sensory and health benefits. Key bioactive components produced or enriched by LAB, such as organic acids, phenolic compounds, melanoidins, and tetramethylpyrazine, have demonstrated health benefits, including antibacterial, antioxidant, anti-inflammatory, and metabolic regulatory effects. These properties position vinegar as a promising functional food with potential health applications. The review also explores advancements in vinegar production, including modernized fermentation processes and optimized aging techniques, which enhance these beneficial compounds and ensure product consistency and safety. By examining the variety of LAB strains and the bioactive profiles of different vinegar types, this study highlights vinegar’s value beyond a culinary product, as a potential therapeutic agent in human nutrition and health. The findings underscore vinegar's relevance not only in dietary and preventive healthcare but also as a potential functional food ingredient. Further research is needed to explore the mechanisms of action through which LAB contribute to vinegar's health benefits, particularly in areas like metabolic regulation, anti-inflammatory effects, and antioxidant properties.
Longitudinal Analysis of Pharmaceutical Expenditures in South Korea: Insights into Alignment with Disease Burden Metrics and Policy Implications
Authors: Yu Seung-Rae , Choi Sooyoung
Published: February 2025

Background
Pharmaceutical expenditures play a pivotal role in healthcare systems, serving as indicators of innovation, equity, and fiscal sustainability. In South Korea, policies such as the Economic Evaluation Exemption (EEE) and Risk-Sharing Agreements (RSAs) aim to enhance access to innovative therapies. At the same time, these policies address rising healthcare costs. However, disparities in expenditure allocation across therapeutic areas persist.

Methods
This retrospective observational study analyzes pharmaceutical expenditures in South Korea from 2007 to 2022, focusing on new chemical entities (NCEs). Data were sourced from the IQVIA MIDAS Global Database, WHO Global Burden of Disease (GBD) database, and South Korea’s National Health Insurance records. Expenditure patterns were benchmarked against OECD and A8 countries using metrics such as Disability-Adjusted Life Years (DALYs, a metric combining years lost due to premature death and disability)

Results
South Korea introduced 276 NCEs by 2022, representing significant growth but remaining below the OECD average. NCE expenditure increased from 10.0% to 16.0% of total pharmaceutical spending between 2017 and 2022, while the A8 average rose from 26.2% to 48.1%. Despite high oncology expenditure aligning with disease burden, chronic diseases—such as musculoskeletal and cardiovascular conditions—were underfunded relative to their DALYs.

Conclusions
South Korea has made notable progress in aligning pharmaceutical spending with public health priorities, particularly in oncology. However, further policy refinements are needed to optimize resource allocation for chronic diseases and achieve equitable, sustainable healthcare outcomes. Expanding RSA frameworks and adopting global best practices—such as increased transparency in expenditure allocation—could address existing gaps more effectively.
Manajemen Pelatihan Coorporate Social Responsibility (CSR) di Coorporate Forum For Comunity Development (CFCD) Jakarta
Authors: Aviani Nur Lis , Zulaikha Siti , Arum Wahyu Sri Ambar
Published: February 2025

This research was conducted at the Division of Training Coorporate Forum For Comunity Development, Jakarta, which aim to identify CSR training management process. This research was conducted on April 2015 to January 2016. This research used qualitative approach with descriptive methode. Data was collected through interview, observation and documentation study. Data sources was gained from Managing Director, Training Manager, Managing Secretary, and several supported informants such as Training Manager Assistant, Training Instructor and CSR Training Participant.Planning of CSR training was conducted by analyzing training needs, arrange curriculum, materials, teaching materials, schedule and organizing recruitment of participants and instructor. While the implementation of training activities carried out through two stages including basic training dan advance training. Evaluation was held by asessing the organizers, training program, materials, instructor, facilities and training participants through four ways to measurereaction,learning, behavior and result.Training Division should be more active and cooperative while planning a training schedule, and give socialization and publication about the importance of CSR training baed on ISO 26000 as much as possibe, altering group discussion formation in order to give encouragement for passive participants to become more active, Reminding participants anymore about the importance of filling evaluation form, establishing cooperation with government and stakeholder to achieve prosperity of civil society by conducting CSR program based on ISO 26000
STRATEGI PEMASARAN JASA PENDIDIKAN DI SMA ISLAM PANGLIMA BESAR SOEDIRMAN 1 BEKASI
Authors: Ershadwi Satria Muhamad Faisal , Listyasari Winda Dewi , Putra Heldy Ramadhan
Published: February 2025

This research is located in SMA Islam Panglima Besar Soedirman 1 Bekasi. This research aims to perceive and obtain empirical data related to marketing strategy in educational service and market positioning. This research is conducted since March 2017 until July 2017. The approach that used in this research is qualitiatve with descriptive method. Data collection is done through interview, observation, and documentation study. The sources of research data came from key informants namely the headmaster of Islamic Senior High School Panglima Soedirman 1 Bekasi, as well as several supporting informants namely Vice Principal of Student Affairs, Vice Principal of Curriculum and Vice Principal Division of Public Relations and Infrastructure.
The results of this study indicate that: (1) market segmentation analysis conducted by SMA Islam Panglima Besar Soedirman 1 Bekasi includes demographic segmentation including segment of education level, economic level, religion and geographical segmentation covering residence segment, (2) SMA Islam Panglima Besar Soedirman 1 Bekasi determines the target market by evaluating the attractive segment, (3) SMA Islam Panglima Besar Soedirman 1 Bekasi determines the market position by showing the superiority and characteristic owned such as school achievement, complete facilities, curriculum with additional religious education Islam, and the quality of schools that have received "A" accreditation and ISO 9001: 2015 certificates, and submitted them to specified target markets.
 
Keywords: Marketing Strategy, Market Segmentation, Targeting, Positioning
HUBUNGAN ANTARA KEADILAN ORGANISASI DAN PERSEPSI DUKUNGAN ORGANISASI DENGAN ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) GURU DI SMP NEGERI SE-KECAMATAN DUREN SAWIT
Authors: Mardiyanti Fitri , Rahmawati Desi
Published: February 2025

This research aims to determine whether there is a relationship between organizational justice and perceived organizational support (POS) with teacherâ€™s organizational citizenship behavior (OCB) on Junior High School in The Duren Sawit Sub District, Jakarta City. This research is quantitative with three variables there in, namely: (X) organizational justice and perceived organizational support (POS) as independent variables and (Y) organizational citizenship behavior (OCB) as the dependent variable. The research using survey method and analyzed data with correlation and regression. The result of the research showed that: (1) there is a positive correlation between organizational justice with organizational citizenship behavior (OCB) (2) there is a positive correlation between perceived organizational support (POS) with organizational citizenship behavior (OCB), and (3) there is a positive correlation between organization justice and percieved organizational support (POS) with organizational citizenship behavior (OCB).
Keywords: organizational justice, perceived organizational support, organizational citizenship behavior
KNOWLEDGE MANAGEMENT DI SUB DIREKTORAT PENILAIAN KINERJA DAN PENGEMBANGAN KARIER GURU PENDIDIKAN DASAR
Authors: Jabar Muhammad Abdul , Zulaikha Siti , Ambar Arum Wahyu sri
Published: February 2025

ABSTRAK
Penelitian dilakukan di Sub Direktorat Penilaian Kinerja dan Pengembangan Karier Guru Pendidikan Dasar, yang bertujuan untuk mengetahui gambaran knowledge management di tempat ini. Penelitian ini dilakukan dari bulan Januari - Juli 2017. Peneliti menggunakan pendekatan kualitatif dan metode deskriptif. Pengumpulan data dilakukan melalui pengamatan, wawancara, dan studi dokumentasi. Sumber dari penelitian ini yaitu: Kepala Subdit, Kepala Sie Penilaian Kinerja, penanggung jawab kelompok kerja dan anggota kelompok kerja..
 
Penciptaan pengetahuan dimulai dari instruksi pimpinan atau pengembangan kebijakan, lalu kepala subdit, kepala sie dan penanggung jawab kelompok kerja diikutsertakan dalam sosialisasi kebijakan tersebut. Hasil dari kegiatan tersebut dibuat pengetahuan baru berupa peraturan pemerintah atau sejenisnya. Pengetahuan baru ini lalu di diskusikan kepada pegawai yang lain sehingga pegawai yang lain mengetahui hasil dari sosialisasi yang diikuti beberapa pegawai. Selain itu, dilakukan juga rolling tugas untuk menambah pengetahuan pegawai. Setelah itu dalam penerapan pengetahuannya pegawai atau kelompok kerja membuat program-program yang sesuai peraturan pemerintah.
 
Sub Direktorat Penilaian Kinerja dan Pengembangan Karier Guru Pendidikan Dasar hendaknya memperbanyak keterlibatan pegawai yang lain dalam proses penciptaan pengetahuan baru untuk mengembangkan kompetensi mereka. Selain itu, diperbanyak bahan bacaan untuk menambah pengetahuan pegawai.
Kata Kunci : Knowledge Management
Current-Sensorless Robust Sliding Mode Control for the DC-DC Buck Converter
Authors: Oucheriah Said
Published: February 2025

A current-sensorless PWM-based robust sliding mode Controller for the DC-DC Buck Converter is proposed. An extended state observer is used to estimate a lumped uncertainty that comprises the uncertain load and input voltage and also to estimate the derivative of the output voltage. A linear sliding surface is used to derive the controller that is simple in its design and yet exhibits excellent features in term of external disturbance suppression. Its robustness is validated by computer simulations using converter examples from two recent studies. Future work will be the validation of these results experimentally.
A physics-informed cluster graph neural network enables generalizable and interpretable prediction for material discovery
Authors: Yang Ming , Cheng Hao , Yang Tong , Zeng Minggang , Wu Hao , Wang Zhengzhong , Hong Haokai , Chen Cheng , Li Bing , Wang Zhongrui , Lau Shu Ping , Lin Wanyu , Tan Kay Chen
Published: February 2025

Machine learning (ML) plays a pivotal role in the development of functional materials, in which graph neural networks (GNNs) have shown improved performance by utilizing the graph representation of atoms and bonds to effectively characterize materials. However, it remains challenging to achieve efficient, robust and interpretable predictions due to the limited integration of domain knowledge. In this study, we propose leveraging the local structure and short-range atomic interactions of materials using a cluster graph representation to improve the performance. This physics-informed cluster graph neural network (CG-NET) significantly enhances computational efficiency through a cluster sampling strategy. Importantly, by incorporating pseudo nodes as neighbors to the nodes at the cluster boundaries, we maintain the bonding coordination environment, enhancing the prediction accuracy. We further demonstrate CG-NET’s remarkable prediction accuracy and efficiency across diverse material systems and properties and reveal its superior interpretability and generalizability with extensive experiments. Our work highlights the importance of integrating domain-specific scientific knowledge into the design of a generalizable and interpretable ML framework. The cluster graph representation in the CG-NET could be extended to other graph-based neural networks to accelerate the development of functional materials while significantly reducing computational cost.
Intracranial Extramedullary Hematopoiesis in a Recently Recovered Monkeypox Patient: A Case Report
Authors: Stev Edward
Published: February 2025

Extramedullary hematopoiesis (EMH) is a compensatory response wherein blood cell production occurs outside the bone marrow, typically as a result of hematologic disorders that impair bone marrow function. Conditions such as myelofibrosis, thalassemia, and sickle cell disease often lead to EMH in organs like the liver and spleen, which serve as alternative sites for hematopoiesis. This case report highlights the importance of considering EMH in the differential diagnosis of intracranial lesions, exemplified by a 67-year-old woman who presented with headaches and generalized malaise. Her medical history included hypertension and mild anemia. Magnetic resonance imaging (MRI) revealed a cystic mass in the right inferomedial parietal lobe, which showed medial mural enhancement, edema, and mass effect, with an additional enhancing focus in the left parietal lobe. Initially suspected to be a hemangioblastoma, the resected mass was found to be a benign vascular lesion with endothelial hyperplasia, but without the characteristics of cavernous hemangioma or vascular malformation. The histopathological examination revealed foci of erythroid and myeloid precursors, and megakaryocytes, with immunohistochemical staining confirming the diagnosis of EMH. Subsequent investigations revealed no underlying hematological disorders, leading to a diagnosis of idiopathic intracranial EMH. The patient underwent intensity-modulated radiation therapy (IMRT) for the remaining lesion and showed significant improvement in symptoms at three months follow-up. This case underscores the diagnostic challenges associated with intracranial lesions and highlights the necessity of considering EMH, particularly when faced with atypical imaging and histopathological features. Future research is needed to optimize therapeutic strategies and assess long-term outcomes for intracranial EMH.
Unlocking the secrets of pegmatite-type lithium deposits: control of melt-fluid mass ratio
Authors: Cao Yonghua , Xiong Yiqu , Fan Zhiwei , Di Hongfei , Dick Jeffrey , Linnen Robert , Jiang Shao-Yong
Published: February 2025

The search for alternatives to traditional fossil fuels has become a global priority, with lithium-ion batteries emerging as a primary substitute for conventional energy sources. The importance of lithium has increased significantly due to the rapid development of new energy vehicles, with spodumene (LiAlSi2O6) being the principal economic mineral for lithium extraction. Spodumene is predominantly found in pegmatites, despite that not all pegmatites are enriched in spodumene. Spodumene-bearing pegmatites are believed to form mainly during magmatic-hydrothermal processes, especially through the differentiation of highly evolved granites. Although fluids can significantly influence the enrichment of lithium, the role is contentious. Magmatic fluids can transport mobile elements (e.g., Li, F, B) and lead to their precipitation and concentration under favorable mineralization conditions. Conversely, fluid interactions may alter and redeposit already crystallized minerals, potentially decreasing the lithium grade. A quantitative assessment of the role of fluids in lithium ore formation is essential for resolving this debate, but the role of fluids is poorly understood. Here, we selected spodumene-bearing pegmatites from two pegmatite fields with well characterized zoned lithologies, Renli-Chuanziyuan and Ke’eryin, to elucidate the key controls on spodumene formation in pegmatites. Through detailed mineralogical observations, geochemistry, and simulation calculations, we propose that spodumene forms after the granitic melt reaches fluid saturation. As fluid mass in the system increases, the amount of spodumene formed initially rises and then declines. Therefore, the melt-fluid mass ratio is critical in controlling spodumene formation. We demonstrate that a melt-fluid mass ratio of ~ 2 is optimal for producing economically significant pegmatite-type lithium deposits, providing important guidance for lithium exploration and prospecting efforts.
DEM-FDM Investigation of Bedding Plane Properties’ Impact on Laminated Roof Stability
Authors: Ma Xiang , Shi Qingwen , Mishra Brijes , Zhao Yun , Ouyang Zhenhua , Guo Zhengjun , Wang Jiyang
Published: February 2025

Laminated roofs are susceptible to cutter roof failure caused by excavation disturbances. To assess the impact of bedding plane properties on their stability under mining stress, a panel-scale numerical model was created using a combination of the discrete element method (DEM) and finite differential method (FDM). The laminated roof was modeled with a bonded particle model (BPM) integrated with a discrete fracture network (DFN) to closely examine fracture behavior, while the surrounding rock was treated as a continuum material. The model was validated through a uniaxial compressive test on Berea sandstone. This validated model was then used to study how varying bedding plane strength and the cohesion-to-tensile strength ratio affect roof deformation, fracturing, and failure during entry development and panel extraction. The findings indicated that entry development caused more roof deformation than panel extraction. Increasing bedding plane strength enhanced the overall stability of the roof, reducing damage to both bedding planes and individual layers. Roof deformation was more sensitive to changes in bedding strength, especially when the bedding was weak. Reducing bedding plane strength led to more shear-tensile cracks and overall damage, particularly in weaker structures. This coupling method was proved to enable the simulation of large-scale panel extraction conditions at an efficient computational cost.
Tracking international development assistance on a global scale and achieving reliable and standardised estimations of bilateral funding for climate-related initiatives through the application of machine learning algorithms
Authors: Badki Meenal
Published: February 2025

First part :Tracking international development assistance offers critical empirical insights for policymakers seeking to fund the Sustainable Development Goals (SDGs). In response to the constraints of current monitoring methodologies, we have devised a machine learning framework that facilitates a thorough and detailed classification of development aid initiatives using the content of their textual descriptions. In particular, we categorise the descriptions of approximately 3.2 million aid initiatives implemented from 2000 to 2018, amounting to a total of US$2.8 trillion. Consequently, 173 activity clusters were produced to encompass the themes of underlying aid activities. Of these, 70 activity clusters pertain to subjects that have yet to undergo empirical analysis, such as reducing greenhouse gas emissions and enhancing maternal healthcare. By examining our activity clusters, global development assistance can be scrutinized for emerging themes and with increased detail, enabling the detection of uncharted spatial and temporal discrepancies. Our proposed framework may be implemented by development finance and policy institutions to facilitate the adoption of evidence-based approaches aimed at advancing the Sustainable Development Goals (SDGs).
Second part: The provision of financial resources at the global level plays a crucial role in attaining the objectives outlined in the Paris Agreement. In this study, a machine learning model was constructed to distinguish international climate finance within a dataset of 2.7 million official development assistance projects spanning the years 2000 to 2019. This process yielded a standardised and reproducible catalog containing 82,023 bilateral climate finance initiatives amounting to US$80 billion. Our results further emphasise the need to consider that the real figures might be significantly lower compared to present estimates utilising Rio markers.
Optimisation of the spray parameters for improved microstructural characteristics in the HVOF Sprayed Cr3C2-20(Ni20Cr) coating
Authors: Venkataraman Hariharan , Bagade Vishal Uttamrao , M. Biju V. , Balam SSK , Tamilselvi M
Published: February 2025

Wear resistance coating of Cr3C2-20(Ni20Cr) is required to be sprayed through High Velocity Oxy Fuel (HVOF) Spray Process on the compressor disc of aero gas turbine engine. The part is made up of Ti6Al4V alloy. While employing the spray parameters recommended by Original Equipment Manufacturer (OEM) for preliminary deposition trials, microstructural defects in the form of vertical cracks were observed. In order to overcome the above microstructural defects, various efforts were sequentially carried out. The initial approach of preheating the substrate at 120°C is aimed at reducing the thermal gradient between the substrate and coating which exhibited partial success. Detailed investigation involving design of experiment using Taguchi L16 Orthogonal array is employed to study the effect of certain critical parameters such as standoff distance, powder feed rate, hydrogen flow rate and Oxygen flow rate. TOPSIS method is used to establish the optimal coating parameters to achieve the crack free coating with the acceptable hardness, porosity and oxide levels. From the above studies, standoff distance 150mm, feed rate 25 g/min, hydrogen flow rate 470 NLPM and Oxygen flow rate 205 NLPM are optimised for crack free HVOF coating of Cr3C2-20(Ni20Cr) on Ti6Al4V substrate and the coating microstructure with the required hardness and the oxides & porosity levels in acceptable range is established for actual component manufacturing.
Introducing Equivalent and Threshold Doses in the Assessment of Medication-Related Osteonecrosis of the Jaw Risk: Insights from a Descriptive Study in Iran
Authors: Mozafari Pegah Mosannen , Molashahi Leila Farhad , Dadgarmoghaddam Maliheh , Kazemian Seyedeh Vajiheh , Fard Amirreza Nabavi , Sharbaf Pooria Aghasizadeh , Azghandi Sajedeh Sheikhi , Sharbaf Parham Aghasizadeh , Friesen Reid ,   Eduardo Rodrigues Fregnani1
Published: February 2025

Purpose:
To investigate the clinical characteristics and risk factors associated with medication-related osteonecrosis of the jaw (MRONJ) and to introduce two metrics—equivalent dose and threshold dose—as predictive risk assessment tools.
Methods:
This retrospective study reviewed 193 patient records from Shahab Clinic and the Oral Medicine Department of Mashhad Dental School (2017–2023). Patients were categorized into MRONJ stages (0–3) and an "at-risk" group. Data on demographics, comorbidities, clinical presentations, and detailed medication profiles were analyzed. Equivalent dose was standardized to four years of oral alendronate use, and threshold dose provided a cumulative risk cut-off. Statistical analyses( T-tests, ANOVA, Chi-square tests,.) were applied .
Results:
MRONJ was identified in 40.4% of cases, while 59.6% were classified as at-risk. Advanced stages were significantly associated with higher equivalent doses, prolonged medication use, and key risk factors, including oncologic diseases, medication type and route of administration, comorbidities, age, and surgical interventions such as extractions and ill-fitting dentures (p < 0.001). The novel metrics demonstrated strong predictive value, with higher equivalent doses correlating closely with MRONJ severity (R = 0.46, p < 0.001)
Conclusion:
This study offers critical insights into MRONJ risk stratification, highlighting the cumulative impact of medication dose alongside clinical risk factors. The introduction of equivalent and threshold doses represents a transformative advancement in MRONJ risk prediction, enabling precise prevention strategies and guiding clinical management toward standardized care protocols.
Privacy-Aware Ransomware Detection in Cloud Environments Using a Hybrid ReLU- GRU, Adaptive Ant Colony Optimization, and Shannon Entropy Framework
Authors: M Thanjai Vadivel , J Jagannathan
Published: February 2025

Ransomware attacks in cloud environments for data storage have an increased concern that demands ransom payments that encrypt critical data. The proposed method is classified based on Shannon Entropy, ReLU-GRU networks and adaptive Ant Colony Optimization (ACO) has been used to enhance the proposed method. The encrypted files are detected utilizing Shanon entropy with file randomness while the sequential data patterns are captured by the ReLU-GRU for the emerging attack patterns for the precise ransom ware classification. The framework is validated using a dataset of 6,245 records, distinguishing ransom ware from benign activity based on system logs, API calls, and process behaviors. Pre-processing techniques, including data normalization, feature extraction, and privacy-preserving API security, refine input data. Results demonstrate 99.13% accuracy, 99.11% precision, 99.07% recall, and a 99.09% F1-score, surpassing methods like SAE-LSTM, GAN, and RLDAC. Shannon Entropy-based API security further prevents unauthorized access. The ROC curve confirms a perfect AUC score of 1.00, while the model achieves a 99.1% detection rate with a false positive rate of just 0.81%, outperforming techniques like SMO and FeSA. The proposed ReLU-GRU + ACO + Shannon Entropy model proves to be efficient, scalable, and privacy-aware. Future research will explore federated learning for distributed detection and zero-trust security architectures to counter advanced ransomware threats.
Spatial but not temporal orienting of attention enhances the temporal acuity of human peripheral vision in an ecologically valid scenario
Authors: Foerster Francois , Giersch Anne , Cleeremans Axel
Published: February 2025

The temporal acuity of a sensory system determines its capacity to detect delays between events, which enables ordering the events in time and adapting behaviors accordingly. Whether and how voluntary attention drives visual temporal acuity is still unclear, especially in peripheral vision. Here, we present a psychophysical study aimed at 1) evaluating whether cue-based spatial and temporal orientation of visual attention modulates the temporal acuity in peripheral vision, 2) assessing to what extent these modulations rely on shared or distinct mechanisms, and 3) exploring whether these modulations are cumulative or independent from each other. To address these goals, forty participants performed an ecologically valid asynchrony detection task in immersive virtual reality whilst electroencephalographic and pupillary dynamics were recorded. We found non-cumulative reductions of pupil constriction during the processing of cues orienting attention in space and time. This suggests that pupil size represents a readout of the formation of cue-based spatiotemporal expectations about visual targets. We further found that pre-target oscillatory dynamics in posterior theta and alpha bands are suppressed by both spatial and temporal orienting of visual attention, with cumulative effects, while beta band activity remains unaffected. These modulations provide evidence for shared and interactive top-down mechanisms of explicit spatial and temporal attention on visual temporal processing. Yet, despite these modulations, only explicit spatial orienting enhances the sensitivity to asynchronies. Implicit, but not cue-based temporal orienting increased task performance. This highlights that explicit endogenous attention directed to space – but not to time – increases the temporal acuity of peripheral vision. Overall, these results cast unambiguous doubts on the accepted trade-off that spatial attention always meliorate spatial visual acuity while impeding temporal visual acuity, and thus call for the further refinement of models of visual attention.
Coated Surgical Sutures: Nanoparticles and nanocomposite as coating materials for absorbable and nonabsorbable wound closure devices
Authors: shebl heba , abdallah rehab , abdallah omnia
Published: February 2025

Upgrading the surgical sutures, as the main wound closure device, is essential. The evolution of bacterial resistance and the plummeting of antibiotics have directed research toward augmented sutures. Nanotechnology has provided answers to these concerns. The use of bacterial isolates as bio-factory for synthesized silver nanoparticles (AgNPs) and silver nanocomposites via a one pot ex situ method provides environmentally friendly silver nanocomposites in addition to the use of chitosan and polyvinyl alcohol polymers as carriers. Transmission electron microscopy (TEM) and zeta potential analysis revealed spherical negatively charged AgNPs. These nanoparticles and nanocomposites were used as coatings for absorbable vicryl and nonabsorbable silk surgical sutures. Atomic force microscopy (AFM) 3D images of these coated sutures showed a significant decrease in surface roughness with improved surface topography, specifically with chitosan-silver (CS-Ag) vicryl coated sutures with effective attachment of the nanocomposite and nanoparticles thin film on the suture surface. Field emission scanning electron microscopy with energy dispersive x-ray spectroscopy (FE-SEM/EDX) analysis showed the significant presence of the thin film of coating materials on the surface of the sutures and the significant elemental presentation of Ag. Vicryl and silk coated CS-Ag sutures showed significant antibacterial and antibiofilm activities against both gram positive and gram negative bacterial isolates. AgNPs coated silk and vicryl sutures recorded the lowest amounts of Ag ions at 0.03–0.45 ppm released after 14 days, while polyvinyl alcohol-silver (PVA-Ag) coated ones showed the highest rates at 0.75–0.93 ppm.
MicroRNA as a predictor of efficacy and safety of clozapine in patients with treatment resistant schizophrenia
Authors: Sosin Dmitry Nikolaevich , Khasanova Aiperi Kylychbekovna , Illarionov Roman Arionovich , Popova Anastasia Konstantinovna , Glotov Andrey Sergeevich , Mosolov Sergey Nilolaevich , Sychev Dmitry Alekseevich
Published: February 2025

Clozapine is the only antipsychotic effective for treatment-resistant schizophrenia. However, it is only effective in 40% of patients with treatment resistant and is associated with a large number of adverse drug reactions. Personalization of clozapine therapy is of great importance to clinical psychiatry. MicroRNA expression is a promising biomarker for predicting the efficacy and safety of clozapine. MicroRNAs are small non-coding RNA molecules, 18–25 nucleotides in length, that participate in transcriptional and post-transcriptional regulation of gene expression. We determined the entire microRNA expression profile in these patients before starting clozapine and after four weeks of clozapine administration. Taking сlozapine alters the expression of twenty-four microRNAs. Levels of hsa-miR-6814-5p, hsa-miR-129-5p, hsa-miR-6068, and hsa-miR-128-1-5p were associated with clozapine efficacy. Analysis of the association between microRNA expression and clozapine safety parameters showed the following: expression levels of hsa-miR-4472 were associated with asthenia, hsa-miR-4472 and hsa-miR-4510 with increased sleep duration, hsa-miR-615-3p and hsa-miR-4715-3p with tachycardia, and hsa-miR-329-1-5p with increased body weight. A number of microRNAs whose expression was altered during clozapine therapy have been shown to be associated with other neuropsychiatric diseases. MicroRNA regulates the expression of a large number of genes, including those involved in the efficacy and safety of clozapine. This fact suggests the prospect of further studies, involving complex analysis of pharmacotranscriptomic and pharmacogenetic biomarkers.
WITHDRAWN: Aortic recoarctation in infants: risk factors and the role of catheter intervention in its management
Authors: Al-Mutairi Mansour B. , Alnajjar Abdulhameed A. , R.Abdelrehim Ayman , Allugmani Mohammad , Morsy Mohamed F. , Khoshhal Saad , Baangood Luna S. , Alahmadti Ahmad , Ishak Abdulaleem , Ibrahim Andreen , Salem Sherif S.
Published: February 2025

Background
Recurrent stenosis after repair of coarctation of aorta (CoA) is not an uncommon problem, the need for surgical re-intervention ranges from 5–.50%. We aimed to identify the risk factors related to the failure of surgical interference in managing CoA and the role of catheter intervention to dilate the stenosis or retraction of the tissue.
Methods
This retrospective cross-sectional study was conducted between January 2017 and December 2023 on 100 patients with congenital heart disease (CHD) with CoA who underwent surgery at Madinah Cardiac Centre. Patients in the age group from 1 day to 30 days at the age of surgery with significant stenosis post-surgery (dynamic or echo picture) were included in the study. Patients with hypoplastic left heart syndrome who had undergone Norwood surgery were excluded from the analysis. The data included gender, age, weight, pre-operative procedures, diagnosis, associated cardiac and non-cardiac anomalies, and type of surgery.
Results
This retrospective cross-sectional study was conducted between January 2017 and December 2023 on 100 patients with congenital heart disease (CHD) with CoA who underwent surgery at Madinah Cardiac Centre. 41% of patients underwent resection and end-to-end anastomosis, 34% underwent extended end-to-end anastomosis, and 25% did complex arch reconstruction. There was a significant improvement in left ventricle function (p < 0.001). Intraoperatively, 5% of patients had complications, 3% had bleeding, and 1% had chest and cardiac complications, while post-operative, 64% had complications, 5% had bleeding, 18% had chest complications, 31% had cardiac complications, and 10% had sepsis. There was a statistically significant decrease in CoA pressure gradient from (48.12 ± 9.57) pre-operative to (22.39 ± 10.8) post-operative, with a statistically significant difference (p < 0.001). (7%) of patients had VSD closure, (2%) died, and (16%) needed post-operative catheterization. Operation low weight increased the risk of surgery failure.
Conclusion
In conclusion, low weight increased the risk of failure of surgery, while age and other anomalies were insignificant factors. Although re-dilatation of the aorta is feasible, such re-expansion may not achieve adult size. Accordingly, alternative solutions may have to be developed and will be reviewed.
Correlation between COVID-19 vaccination and inflammatory musculoskeletal disorders: analysis of Korean National Health Insurance database
Authors: Park Young Hwan , Kim Min Ho , Kim Hong Jin , Choi Myeong Geun , Chun Eun Mi
Published: February 2025

The aim of this study was to investigate the incidence rates of inflammatory musculoskeletal disorders following COVID-19 vaccination and compare them with those in unvaccinated individuals. We used data from 2,218,715 individuals in the Korean National Health Insurance Service database and investigated the incidence rates of inflammatory musculoskeletal disorders following COVID-19 vaccination. At 12 weeks after vaccination, the cumulative incidence rates of plantar fasciitis (0.14–0.17%), rotator cuff syndrome (0.29–0.42%), adhesive capsulitis (0.29–0.47%), HIVD (0.18–0.23%), spondylosis (0.14–0.23%), bursitis (0.02–0.03%), Achilles tendinitis (0.0–0.05%), and de-Quervain tenosynovitis (0.04–0.05%) were higher in all three vaccinated groups (mRNA vaccine, viral vector vaccine, and mixing and matching) compared with the unvaccinated group. All COVID-19 vaccines were identified as significant risk factors for inflammatory musculoskeletal disorders (odds ratio, 1.404 to 3.730) except for the mixing and matching vaccines for de Quervain tenosynovitis. This study suggests a strong correlation between inflammatory musculoskeletal disorders and COVID-19 vaccination concerning adverse reactions.
Medical education: is the reel a good deal?
Authors: Pozza Daniel Humberto , Neto Fani Lourença , Costa-Pereira José Tiago , Tavares Isaura
Published: February 2025

Based on our question, "Is the reel a good deal for medical education?" this study explores the effectiveness of short (around 2 minutes) video-based learning in engaging students enrolled in a medical course. With the increasing integration of digital tools in education, video content has emerged as a dynamic method to enhance learning experiences. This cross-sectional survey was conducted by using anonymous self-administered questionnaires, prepared taking into account previous studies, to 264 informed students that voluntarily agreed to participate. This sample represented 75.5% of the students’ attending the classes. The questionnaires included topics related to 65 short videos about practical classes and learning preferences. The collected data were analyzed using descriptive and comparative statistics. The students considered that the content and format of the videos were adequate (99.6% and 100%, respectively). Specifically, the videos helped the students to better understand the practical classes, consolidate and retain the practical content and simplify the study for the exams. Additionally, the videos were praised for their high-quality audiovisual content, being innovative, complete, concise, short and/or adequate, or better than other formats such as printed information. The combination of written and audiovisual support materials for teaching and studying is important and has been shown to improve students’ performance. This pedagogical methodology is well-suited for the current generation of students, aiding not only in study and exam preparation but is also in remote learning.
Population dynamics of Schrödinger cats
Authors: Thompson Foster , Kamenev Alex
Published: February 2025

We demonstrate an exact equivalence between classical population dynamics and Lindbladian evolution admitting a dark state and obeying a set of certain local symmetries. We then introduce quantum population dynamics as models in which this local symmetry condition is relaxed. This allows for non-classical processes in which animals behave like Schrödinger’s cat and enter superpositions of live and dead states, thus resulting in coherent superpositions of different population numbers. We develop a field theory treatment of quantum population models as a synthesis of Keldysh and third quantization techniques and draw comparisons to the stochastic Doi-Peliti field theory description of classical population models. We apply this formalism to study a prototypical “Schrödinger cat” population model on a dd-dimensional lattice, which exhibits a phase transition between a dark extinct phase and an active phase that supports a stable quantum population. Using a perturbative renormalization group approach, we find a critical scaling of the Schrödinger cat population distinct from that observed in both classical population dynamics and usual quantum phase transitions.
TRANSIENT FAMILIAL CONGENITAL HYPOTHYROIDISM: ABOUT A SIBLING OF THREE
Authors:   Endocrinology, Diabetology, MetabolicDiseases and Nutrition Department, FMPM, Cadi AyyadUniversity, CHU Mohamed VI Marrakech., Rania Dassoufi , Sana Rafi ,   Endocrinology, Diabetology, MetabolicDiseases and Nutrition Department, FMPM, Cadi AyyadUniversity, CHU Mohamed VI Marrakech., Mghari Ghizlane EL ,   Endocrinology, Diabetology, MetabolicDiseases and Nutrition Department, FMPM, Cadi AyyadUniversity, CHU Mohamed VI Marrakech., Ansari Nawal EL ,   Endocrinology, Diabetology, MetabolicDiseases and Nutrition Department, FMPM, Cadi AyyadUniversity, CHU Mohamed VI Marrakech.
Published: February 2025

Introduction:Congenitalhypothyroidismis one of the mostcommonpreventable causes of intellectualdisability. It isclassifiedinto permanent and transient. The transientdisorderrefers to atemporarydeficiency of thyroid hormones at birth but thenrecovering to normal thyroid hormone production.Wewillpresent a case of congenitalhypothyroidism in a sibling of three.

Case Report:Symptomatologyseems to date back to the age of 2 months in the first two siblings for whichtheywerehospitalized in pediatrics for hypotonia and macroglossiaassociated to anemia.Contrastingwith the youngest sibling whowasscreened at day 7 of life .Biologicalfindingsrevealedhypothyroidism.Supplemented by ultrasoundshowing a normal thyroid volume, whilethyroidscintigraphyrevealed a moderatelyreduced fixation.Theywere all put on Levothyroxin. However, wenoted a spontaneousimprovement in theyoungestbrotherleading to cessation of hormone replacement therapy at the age of 5.

Discussion:Whilethyroiddysgenesisremains the mostcommon cause of congenitalhypothyroidism, theincidence of dyshormonogenesis has been increasing over the last few decades.Transienthypothyroidismmaybecaused by mutations in the genesencodingessentialy forDUOX2/DUOXA2 suspected in our sibling due to the transientcaracter in youngerbrother.However, mutations in pendrine, sodium iodinesymporter, thyroidperoxidade, thyroglobulingenes are oftenassoxiatedwithgoiter and severe permanent hypothyroidism.Finally, new born screening and effective treatmentis a major achievement in preventivemedicine.
A Pipeline Protocol to Design, Discover and Research on Peptide Inhibitors and Binding Sites for Neglected Tropical Diseases: An Application for Leishmaniasis
Authors: E. S. M. T. Bonfim Natanael , Q. Pantaleão Simone , A. Calderon Leonardo , Allison Philot Eric , Scott Ana Ligia
Published: February 2025

According to the World Health Organization, leishmaniasis is considered a complex disease
caused by several species of protozoan parasites of the genus Leishmania and can manifest itself
in three ways: visceral, cutaneous, and mucocutaneous. The usual treatment of leishmaniasis is
based on excessively prolonged regimens and the application of drugs that cause undesirable
effects, in addition to the records of pharmaco resistance already demonstrated in several cases,
highlighting the relationship of the role of parasite virulence in resistance to the main antimonials,
amphotericin B and pentamidine. These factors make it difficult to treat leishmaniasis. We proposed
a pipeline to select and analyze candidates to be a target design, discover and investigate inhibitory
peptides acting and binding sites for neglected tropical diseases according to the physical-chemical
properties of the peptides and target candidates. Particularly, we applied the protocol to investigate
the trypanothione reductase to aid in the treatment of leishmaniasis as a case of study. The protocol
for Leishmania infantum, L. panamensis and L. major (species with information deposited on online
platforms), obtaining interest results. Besides, these results show three good peptide candidates
for inhibiting the trypanothione reductase (a specific target selected by the pipeline). The three
peptides selected according to the protocol can be a good lead compound with small and specific
changes in their composition/structure. Our results indicated that the protocol works well for large
amounts of data and can be applied to other molecular targets as well as other diseases for which
data and structures are deposited in databases. It is important to highlight these results should be
refined with in vitro assays.
GMINY UZDROWISKOWE WOBEC WYZWAŃ ZWIĄZANYCH Z OCHRONĄ POWIETRZA
Authors: Woźniak Marta
Published: February 2025

Przedmiotem opracowania jest odpowiedź na pytania, jakie wyzwania stoją przed gminami uzdrowiskowymi w aspekcie ochrony powietrza oraz czy prawo powszechnie obowiązujące pozwala na osiągnięcie zadowalającego stanu ochrony powietrza w polskich uzdrowiskach. W tym celu zostaną przedstawione instrumenty prawne ochrony powietrza w gminach uzdrowiskowych, z uwzględnieniem instrumentów zawartych w systemie prawa ochrony środowiska. Jednym z ważnych pytań badawczych jest pytanie, czy przekroczenie jednego ze wskaźników dotyczących zanieczyszczeń powietrza, na przykład pyłu zawieszonego PM10, może stanowić przesłankę do utraty statusu uzdrowiska. Przegląd instrumentów prowadzi do wniosku, że przepisy powszechnie obowiązującego prawa nie dostrzegają odrębności klimatycznej gmin uzdrowiskowych, a uzdrowiska nie dysponują sobie tylko poświęconymi instrumentami ochrony powietrza. Instrumenty prawne ochrony powietrza w gminach uzdrowiskowych są rozproszone w systemie prawa ochrony środowiska i prawa uzdrowiskowego. Autorka postuluje wzmocnienie środków kontroli i prowadzenie regularnego monitoringu środowiska w zakresie ochrony powietrza w uzdrowiskach.
LIST 153 ŚW. AUGUSTYNA TEKST – TŁUMACZENIE – KOMENTARZ CZĘŚĆ II
Authors: Kubala Maciej
Published: February 2025

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Torsión esplénica: reporte de caso en paciente pediátrico
Authors: Argüello Bolaños Emilio , Canseco García Reynaldo , Alanis Coello Gerardo Adolfo , Marrufo Sumano Esteban
Published: February 2025

Wandering spleen is an uncommon condition caused by the absence or hyperlaxity of the splenic ligaments, allowing its displacement into the lower abdomen and leaving it suspended solely by its elongated vascular pedicle. This pathology can be asymptomatic or present with acute or chronic abdominal pain, depending on the extent of pedicle torsion and the degree of vascular compromise. We present the case of a 4-year-old pediatric patient who was admitted to the emergency department with an acute abdomen following abdominal trauma. During exploratory laparotomy, splenic pedicle torsion with splenic necrosis was identified, necessitating a splenectomy. The diagnosis was supported by imaging findings of splenomegaly and extensive subcapsular hemorrhage, while intraoperative analysis revealed a 12 cm spleen adhered to the gastrocolic omentum, with the absence of most splenic ligaments. Although splenopexy is the treatment of choice for viable spleens, in this case, splenectomy was required due to the organ's nonviability. This report emphasizes the importance of early diagnosis and timely surgical management to prevent complications associated with this rare condition. Keywords: Wandering spleen; splenic torsion; splenectomy; splenopexy; splenic ligaments; acute abdomen; abdominal trauma; splenomegaly; subcapsular hemorrhage; early diagnosis.
Efecto de la elección de carrera en la calidad en instituciones de educación superior
Authors: García-Martínez Rafael , Noriega-Morales Salvador A. , Poblano-Ojinaga Eduardo-Rafael
Published: February 2025

La demanda de los servicios educativos que ofrecen las instituciones de educación superior es una medida de calidad. Determinar los factores y la magnitud de sus efectos sobre los alumnos egresados del bachillerato al elegir una carrera y dónde cursarla es una herramienta útil en el proceso de gestión de la calidad para este tipo de instituciones. El objetivo de este trabajo es identificar y cuantificar los efectos de los factores que impactan en la selección de la carrera universitaria y de la universidad. Para lograr dicho objetivo se construye un modelo predictivo lineal de segundo orden, con el factor elección de carrera como variable endógena y los factores: prestigio de la institución, economía, ubicación de la institución, servicios, infraestructura y factores emocionales como variables exógenas. El modelo se estima con una muestra de 237 alumnos que se analiza mediante el método de modelos de ecuaciones estructurales con el enfoque de mínimos cuadrados parciales. Los valores estimados de los seis parámetros considerados en el modelo lineal son estadísticamente significativos. Cinco de estos valores, que tienen mayor efecto sobre la variable endógena, no presentan diferencia significativa entre sí. El menor valor con diferencia significativa respecto al resto corresponde al de la variable exógena ubicación.