bluuebunny/crossref_metadata_2025 huggingface dataset:
Solution of the heavily stacking faulted crystal structure of the honeycomb iridate H3LiIr2O6
Authors: Bette Sebastian , Takayama Tomohiro , Kitagawa Kentaro , Takano Riku , Takagi Hidenori , Dinnebier Robert E.
Published: September 2017

The idealized and real crystal structure of the heavily faulted honeycomb iridate H3LiIr2O6 was solved from XRPD and PDF data.
Investigation of the role of morphology on the magnetic properties of Ca2Mn3O8 materials
Authors: Vera Stimpson Laura J. , Ramos Silvia , Stenning Gavin B. G. , Jura Marek , Parry Stephen , Cibin Giannantonio , Arnold Donna C.
Published: September 2017

Ca2Mn3O8 exhibits a complex ‘bow-tie’ magnetic lattice resulting in interesting magnetic behaviour.
Conjugated fatty acid-rich oil from Gynostrmma pentaphyllum seed can ameliorate lipid and glucose metabolism in type 2 diabetes mellitus mice
Authors: Zhang Mingxing , Du Nan , Wang Lu , Wang Xiaobing , Xiao Yaping , Zhang Kun , Liu Quanhong , Wang Pan
Published: September 2017

Gynostrmma pentaphyllumseed oil (GPSO), extracted fromG. pentaphyllumseeds, is rich in conjugated linolenic acid, which is a special fatty acid consisting ofcis-9,trans-11,trans-13 isomers.
Thiol–ene chemistry for polymer coatings and surface modification – building in sustainability and performance
Authors: Resetco C. , Hendriks B. , Badi N. , Du Prez F.
Published: September 2017

Thiol–ene chemistry is a powerful tool for the sustainable development of functional coatings and surfaces with a variety of building blocks. This review highlights the advantages of thiol–ene chemistry for the development of UV-cured, bio-based, optical and speciality coatings and for surface modification.
Wide concentration liquid crystallinity of graphene oxide aqueous suspensions with interacting polymers
Authors: Shim Yul Hui , Lee Kyung Eun , Shin Tae Joo , Kim Sang Ouk , Kim So Youn
Published: September 2017

Polymers may effectively lower the critical concentration for isotropic-to-nematic phase transition, and retard the glass transition of a GO suspension.
Copper(i)-catalyzed 5-exo-trig radical cyclization/borylation of alkyl halides: access to functionalized pyrrolidine derivatives
Authors: Cui Jie , Wang Hui , Song Jian , Chi Xiaochen , Meng Long , Liu Qing , Zhang Daopeng , Dong Yunhui , Liu Hui
Published: September 2017

This work reports the copper(i)-catalyzed 5-exo-trigradical cyclization/borylation of alkyl halides bearing an alkene moiety, during which a C–C bond and a C–B bond were formed in one step.
Giant Pockels effect of polar organic solvents and water in the electric double layer on a transparent electrode
Authors: Kanemaru Hironori , Yukita Shunpei , Namiki Hajime , Nosaka Yugo , Kobayashi Takayoshi , Tokunaga Eiji
Published: September 2017

The Pockels effect of polar organic solvents and water within the electric double layer on an ITO electrode is studied to find that water has the largest Pockels coefficient, followed in order by methanol, ethanol, and dimethyl sulfoxide.
Heteropolytungstostannate as a homo- and heterogeneous catalyst for Knoevenagel condensations, selective oxidation of sulfides and oxidative amination of aldehydes
Authors: Khoshnavazi Roushan , Bahrami Leila , Rezaei Manuchehr
Published: September 2017

Heteropolytungstostannate of [P2W18O68(HOSnIVOH)3]12− was grafted on amine levels coated magnetic nanoparticles and used as catalysis in the selective oxidation of sulfides and oxidative amination of aldehydes in an aqueous medium.
Ion exchange-prepared NaSbSe2 nanocrystals: electronic structure and photovoltaic properties of a new solar absorber material
Authors: Aragaw Belete Asefa , Sun Jifeng , Singh David J. , Lee Ming-Way
Published: September 2017

We report the calculated electronic structure, syntheses and photovoltaic properties of a new ternary solar absorber material NaSbSe2.
Five Co(ii) coordination polymers with different counter anions based on [3,5-di(4H-1,2,4-triazol-4-yl)benzoato]− ligand: directed synthesis, structures and magnetic properties
Authors: Jiang Wen-Hong , Zhang Han-Zhong , Hou Guang-Feng , Ma Dong-Sheng , Liu Bin , Yu Ying-Hui
Published: September 2017

Five cobalt(ii) coordination polymers were synthesized by reactions of HL with varied cobalt(ii) salts and different templates under solvothermal conditions.
Bifunctional electro-catalytic performances of CoWO4 nanocubes for water redox reactions (OER/ORR)
Authors: AlShehri Saad M. , Ahmed Jahangeer , Ahamad Tansir , Arunachalam Prabhakarn , Ahmad Tokeer , Khan Aslam
Published: September 2017

In this paper, we report the synthesis of cube shaped nanoparticles of CoWO4 (∼30 nm) by molten salts and their bifunctional electro-catalytic activities in water redox reactions for oxygen evolution and oxygen reduction reactions (OER and ORR).
Focused ultrasound actuation of shape memory polymers; acoustic-thermoelastic modeling and testing
Authors: Bhargava Aarushi , Peng Kaiyuan , Stieg Jerry , Mirzaeifar Reza , Shahab Shima
Published: September 2017

Controlled drug delivery (CDD) technologies have received extensive attention recently.
Introducing DDEC6 atomic population analysis: part 3. Comprehensive method to compute bond orders
Authors: Manz Thomas A.
Published: September 2017

A new method to compute accurate bond orders for metallic, covalent, polar-covalent, ionic, multi-centered, aromatic, dative, dispersion, and hydrogen bonding.
Synthesis, structures and magnetic properties of isoreticular polyrotaxane-type two-dimensional coordination polymers
Authors: Park In-Hyeok , Herng Tun Seng , Ju Huiyeong , Ding Jun , Lee Shim Sung , Vittal Jagadese J.
Published: September 2017

The variable temperature magnetic properties have been investigated for two isoreticular polyrotaxane-type coordination polymers of Co(ii) with bent and two linear dinitrogen spacers.
Activation of persulfate by MMIOC for highly efficient degradation of rhodamine B
Authors: Xie Huanling
Published: September 2017

Mesoporous magnetic iron oxide composites (MMIOCs) were successfully prepared by one-step evaporation induced self-assembly using an organic ferrocene surfactant, and innovatively studied as a potential alternative to Co3O4 for persulfate activation to generate radicals.
The use of dual reductants in gold nanoparticle syntheses
Authors: Wrigglesworth E. G. , Johnston J. H.
Published: September 2017

Two reducing agents can be used simultaneously to control nanoparticle shape and produce anisotropic nanoparticles without a structure directing agent.
Lignocellulosic biomass-derived, graphene sheet-like porous activated carbon for electrochemical supercapacitor and catechin sensing
Authors: Veeramani Vediyappan , Sivakumar Mani , Chen Shen-Ming , Madhu Rajesh , Alamri Hatem R. , Alothman Zeid A. , Hossain Md. Shahriar A. , Chen Ching-Kuo , Yamauchi Yusuke , Miyamoto Nobuyoshi , Wu Kevin C.-W.
Published: September 2017

We synthesize graphene sheet-like porous activated carbon (GPAC) with a high specific surface area by using Bougainvillea spectabilis as a precursor with the assistance of a facile and reliable chemical activation method.
Highly effective and reusable sulfonated pentablock copolymer nanocomposites for water purification applications
Authors: Filice S. , D'Angelo D. , Scarangella A. , Iannazzo D. , Compagnini G. , Scalese S.
Published: September 2017

Sulfonated pentablock copolymer nanocomposites loaded with TiO2 or graphene oxide show their effectiveness in water purification applications.
Simple and low-cost thiophene and benzene-conjugated triaryamines as hole-transporting materials for perovskite solar cells
Authors: Wu Jianchang , Liu Chang , Deng Xiang , Zhang Luozheng , Hu Manman , Tang Jun , Tan Wenchang , Tian Yanqing , Xu Baomin
Published: September 2017

Two novel hole transporting materials were developed, which have comparable performance to that of spiro-OMeTAD but could be of lower cost.
Internal short circuit mitigation of high-voltage lithium-ion batteries with functional current collectors
Authors: Wang Meng , Shi Yang , Noelle Daniel J. , Le Anh V. , Yoon Hyojung , Chung Hyeseung , Zhang Minghao , Meng Ying Shirley , Qiao Yu
Published: September 2017

A functional current collector was developed to mitigate the internal short circuit in high-voltage lithium-ion batteries.
Preparation of porous TiO2 photocatalyts with different crystal phases and high catalytic activity by simple calcination of titanate nanofibers
Authors: Peng Yulan , Shen Xiaojun , Wang Lingzhi , Tian Baozhu , Liu Yongdi , Chen Haijun , Lei Juying , Zhang Jinlong
Published: September 2017

Porous TiO2 materials with different crystal phases and large surface area were prepared by calcining titanate nanofibers under different temperatures for efficient photocatalysis.
Highly flexible and semi-transparent Ag–Cu alloy electrodes for high performance flexible thin film heaters
Authors: Cho Kyung-Su , Kim Eunah , Kim Dong-Wook , Kim Han-Ki
Published: September 2017

We investigated the properties of thermally evaporated Ag–Cu films for application as flexible and semi-transparent electrodes for semi-transparent flexible thin film heaters (TFHs) and heat shielding films (HSFs).
Evidence of enhanced photocurrent response in corannulene films
Authors: Pastukhova N. , Samos L. Martin , Zoppi L. , Pavlica E. , Mathew J. , Bratina G. , Siegel J. S. , Baldridge K. K.
Published: September 2017

Experimental optical absorption and photoconductivity spectra of thin films with GW–BSE theoretical predictions provide evidence for diffuse super atomic molecular orbitals (SAMOs) in corannulene, C20H10.
An ultra melt-resistant hydrogel from food grade carbohydrates
Authors: Thompson Benjamin R. , Horozov Tommy S. , Stoyanov Simeon D. , Paunov Vesselin N.
Published: September 2017

We have formulated an ultra melt-resistant composite hydrogel with tailorable rheology over a range of temperatures.
Tailoring the performance of magnetic elastomers containing Fe2O3 decorated carbon nanofiber
Authors: Lee Dongju , Kwon O.-Seok , Song Sung Ho
Published: September 2017

One important strategy for developing high performance smart materials is to utilize the magnetic properties of elastomers.
K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols
Authors: Wen Chunxiao , Chen Qian , Huang Yulin , Wang Xiaofeng , Yan Xinxing , Zeng Jiekun , Huo Yanping , Zhang Kun
Published: September 2017

Phosphorylation of thiols has been achievedviaK2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols.
Beneficial effects of Trametes versicolor pretreatment on saccharification and lignin enrichment of organosolv-pretreated pinewood
Authors: Kandhola Gurshagan , Rajan Kalavathy , Labbé Nicole , Chmely Stephen , Heringer Nelson , Kim Jin-Woo , Hood Elizabeth E. , Carrier Danielle Julie
Published: September 2017

Fungi-treated pinewood yields more organosolv lignin rich inp-hydroxyphenyl (H) subunits.
Controlled formation of flavor compounds by preparation and application of Maillard reaction intermediate (MRI) derived from xylose and phenylalanine
Authors: Cui Heping , Jia Chengsheng , Hayat Khizar , Yu Jingyang , Deng Shibin , Karangwa Eric , Duhoranimana Emmanuel , Xia Shuqin , Zhang Xiaoming
Published: September 2017

An effective method for preparing Maillard reaction intermediate (MRI) derived from xylose (Xyl) and phenylalanine (Phe) in aqueous medium was proposed in this study.
Ring-locking strategy facilitating determination of absolute optical purity of 2-amino-1-butanol by reverse-phase high-performance liquid chromatography
Authors: Li Bo , Zhang Jie , Yang Bei-Bei , Li Li , Yang Xiao-Xiao
Published: September 2017

A concise and efficient reverse-phase high-performance liquid chromatography (RPLC) method has been established for absolute optical purity assay of 2-amino-1-butanol, which is an important synthetic intermediate of various drugs.
Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: validation of their authenticity via in situ chemical analysis
Authors: Rivera-Chávez José , Raja Huzefa A. , Graf Tyler N. , Gallagher Jacklyn M. , Metri Prashant , Xue Ding , Pearce Cedric J. , Oberlies Nicholas H.
Published: September 2017

A new technique was used to monitor the chemistry of fungal cultures in situ, thereby confirming authenticity of secondary metabolites.
Hydrothermal synthesis of narrow-band red emitting K2NaAlF6:Mn4+phosphor for warm-white LED applications
Authors: Cheng Haiming , Song Yan , Liu Guixia , Li Dan , Dong Xiangting , Wang Jinxian , Yu Wensheng
Published: September 2017

The truncated octahedron shaped K2NaAlF6:Mn4+was preparedviahydrothermal route, which emits red light under blue light radiation. Warm WLEDs fabricated by the obtained red phosphor show lower color temperature and higher color rendering index.
Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering
Authors: Steiniger Charlotte , Hoffmann Sylvester , Mainz Andi , Kaiser Marcel , Voigt Kerstin , Meyer Vera , Süssmuth Roderich D.
Published: September 2017

Hybrid fungal CDP synthetases are constructed from three different origins to produce highly active cyclodepsipeptides up to g L−1 scale.
Size and charge effect of guest cations in the formation of polyoxopalladates: a theoretical and experimental study
Authors: Lang Zhongling , Yang Peng , Lin Zhengguo , Yan Likai , Li Ming-Xing , Carbó Jorge J. , Kortz Ulrich , Poblet Josep M.
Published: September 2017

The close interplay of theoretical and experimental techniques can facilitate the understanding and rational synthesis of novel inorganic clusters, and here an impressive example is shown for the class of cuboid-shaped polyoxo-12-palladates(ii) with a central metal ion guest.
3D hole-transporting materials based on coplanar quinolizino acridine for highly efficient perovskite solar cells
Authors: Zhang Mingdao , Wang Gang , Zhao Danxia , Huang Chengyan , Cao Hui , Chen Mindong
Published: September 2017

A new concept of HTMs for PSCs: a 3D structure with a core of coplanar quinolizino is firstly put forward and demonstrated to be highly effective, and it is derived from the conventional concept of 2D triphenylamine HTM.
Influence of axle length on the rate and mechanism of shuttling in rigid H-shaped [2]rotaxanes
Authors: Gholami Ghazale , Zhu Kelong , Baggi Giorgio , Schott Eduardo , Zarate Ximena , Loeb Stephen J.
Published: September 2017

Shuttling rates for neutral and charged [2]rotaxanes with rigid axles varying in lengths from 7.4 to 20.3 Å were found to be independent of the length of the axle, except when the distance was short enough to allow the ring to interact with both recognition sites which provided a short-cut mechanism that significantly lowered the energy barrier.
Integration of intracellular telomerase monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive oxygen species
Authors: Zhang Huairong , Li Binxiao , Sun Zhaomei , Zhou Hong , Zhang Shusheng
Published: September 2017

ROS and polyluminol–Pt NPs were used for intracellular telomerase detection and to induce apoptosis in HL-60 cancer cells with high efficacy.
Mechanically induced pyrogallol[4]arene hexamer assembly in the solid state extends the scope of molecular encapsulation
Authors: Journey Sara N. , Teppang Kristine L. , Garcia Cesar A. , Brim Shaylyn A. , Onofrei David , Addison J. Bennett , Holland Gregory P. , Purse Byron W.
Published: September 2017

Ball milling mixtures of pyrogallol[4]arene and guests gives direct access to encapsulation complexes and can be monitored by solid-state NMR.
Cross-linking Zr-based metal–organic polyhedra via postsynthetic polymerization
Authors: Nam Dongsik , Huh Jihyun , Lee Jiyoung , Kwak Ja Hun , Jeong Hu Young , Choi Kyungmin , Choe Wonyoung
Published: September 2017

Zr-based MOP cages are cross-linked with flexible organic molecules through a condensation reaction, resulting in a highly crystalline framework.
Vapor-fed solar hydrogen production exceeding 15% efficiency using earth abundant catalysts and anion exchange membrane
Authors: Heremans Gino , Trompoukis Christos , Daems Nick , Bosserez Tom , Vankelecom Ivo F. J. , Martens Johan A. , Rongé Jan
Published: September 2017

A vapor-fed solar hydrogen generator with KOH-doped poly(vinyl alcohol) anion exchange membrane flanked with NiFe and NiMo catalysts is demonstrated.
Influence of lipid composition of model membranes on methacrylate antimicrobial polymer–membrane interactions
Authors: Baul Upayan , Vemparala Satyavani
Published: September 2017

Using atomistic molecular dynamics simulations, the role of lipid composition in the interactions of multiple methacrylate antimicrobial polymer agents with model membranes, and the consequent response of the membranes is studied.
Capacitance-enhanced sodium-ion storage in nitrogen-rich hard carbon
Authors: Gaddam Rohit Ranganathan , Farokh Niaei Amir H. , Hankel Marlies , Searles Debra J. , Kumar Nanjundan Ashok , Zhao X. S.
Published: September 2017

Nitrogen-rich hard carbon with enhanced capacitive storage for room temperature sodium-ion battery is investigated. The presence of nitrogen allows stronger sodium ion interaction to realize high-performance batteries with a specific capacity of ∼204 mA h g−1 after 1000 cycles at 1 A g−1 current density.
Powerful synergy: efficient Pt–Au–Si nanocomposites as state-of-the-art catalysts for electrochemical hydrogen evolution
Authors: Jiang Binbin , Tang Zeyuan , Liao Fan , Lin Haiping , Lu Shunkai , Li Youyong , Shao Mingwang
Published: September 2017

With low Pt loading, Pt–Au–SiNW-2 exhibited a lower Tafel slope, more efficient hydrogen production and better stability than commercial 40 wt% Pt/C. The outstanding catalytic performance might be derived from a stepwise reaction pathway.
Greatly improving energy storage density and reducing dielectric loss of carbon nanotube/cyanate ester composites through building a unique tri-layered structure with mica paper
Authors: Zhang Xiaobao , Yuan Li , Guan Qingbao , Liang Guozheng , Gu Aijuan
Published: September 2017

Carbon nanotube/cyanate ester–mica paper tri-layered structure composites with markedly high energy storage density and low dielectric loss were developed.
Nanostructured Li2MnO3: a disordered rock salt type structure for high energy density Li ion batteries
Authors: Freire M. , Lebedev O. I. , Maignan A. , Jordy C. , Pralong V.
Published: September 2017

Nowadays the energy storage challenge is to develop a low cost, ecofriendly, high energy density material, showing a reversible capacity higher than 250 mA h g−1.
Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy
Authors: Liu Siyang , Yuan Ye , Yang Yingkun , Liu Zhihe , Yin Shengyan , Qin Weiping , Wu Changfeng
Published: September 2017

The dual-photosensitizer upconversion nanoplatform takes advantage of upconversion luminescence and generates singlet oxygen and free radicals for enhanced photodynamic therapy.
Organic thin films with charge-carrier mobility exceeding that of single crystals
Authors: Lamport Zachary A. , Li Ruipeng , Wang Chao , Mitchell William , Sparrowe David , Smilgies Detlef-M. , Day Cynthia , Coropceanu Veaceslav , Jurchescu Oana D.
Published: September 2017

Through processing, spin-cast OTFTs outperform single-crystal OFETs by making accessible the high-mobility direction in the same crystal structure.
Evaluation of the toxicity of iron-ion irradiation in murine bone marrow dendritic cells via increasing the expression of indoleamine 2,3-dioxygenase 1
Authors: Xie Yi , Yan Jun-Fang , Ma Jing-Yi , Li Hong-Yan , Ye Yan-Cheng , Zhang Yan-Shan , Zhang Hong
Published: September 2017

Elevated JNK and IDO1 induced by Fe ion IR could result in dysfunction of BMDCs.
Photospheric activity of the Sun with VIRGO and GOLF
Authors: Salabert D. , García R. A. , Jiménez A. , Bertello L. , Corsaro E. , Pallé P. L.
Published: September 2017

We study the variability of solar activity using new photospheric proxies originally developed for the analysis of stellar magnetism with the CoRoT and Kepler photometric observations. These proxies were obtained by tracking the temporal modulations in the observations associated with the spots and magnetic features as the Sun rotates. We analyzed 21 yr of observations, spanning solar cycles 23 and 24, collected by the space-based photometric VIRGO and radial velocity GOLF instruments on board the SoHO satellite. We then calculated the photospheric activity proxy Sph is for each of the three VIRGO photometers and the associated Svel proxy from the radial velocity GOLF observations. Comparisons with several standard solar activity proxies sensitive to different layers of the Sun demonstrate that these new activity proxies, Sph and Svel, provide a new manner to monitor solar activity. We show that both the long- and short-term magnetic variabilities respectively associated with the 11-yr cycle and the quasi-biennial oscillation are well monitored, and that the magnetic field interaction between the subsurface, photosphere, and chromosphere of the Sun was modified between Cycle 24 and Cycle 23. Furthermore, the photometric proxies show a wavelength dependence of the response function of the solar photosphere among the three channels of the VIRGO photometers, providing inputs for the study of the stellar magnetism of Sun-like stars.
The International Academy of Health Sciences Informatics: An Academy of Excellence
Authors: Lehmann C. U. , Park H.-A. , Shortliffe E. H. , Degoulet P.
Published: September 2017

This article will appear in the next few weeks
Sensor, Signal, and Imaging Informatics
Authors: Hsu W. , Park S. , Kahn Charles
Published: September 2017

Objective: To summarize significant contributions to sensor, signal, and imaging informatics published in 2016.

Methods: We conducted an extensive search using PubMed® and Web of Science® to identify the scientific contributions published in 2016 that addressed sensors, signals, and imaging in medical informatics. The three section editors selected 15 candidate best papers by consensus. Each candidate article was reviewed by the section editors and at least two other external reviewers. The final selection of the six best papers was conducted by the editorial board of the Yearbook.

Results: The selected papers of 2016 demonstrate the important scientific advances in management and analysis of sensor, signal, and imaging information.

Conclusion: The growing volume of signal and imaging data provides exciting new challenges and opportunities for research in medical informatics. Evolving technologies provide faster and more effective approaches for pattern recognition and diagnostic evaluation. The papers selected here offer a small glimpse of the high-quality scientific work published in 2016 in the domain of sensor, signal, and imaging informatics.
Clinical Research Informatics: Contributions from 2016
Authors: Daniel C. , Choquet R.
Published: September 2017

Objectives: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select the best papers published in 2016.

Methods: A bibliographic search using a combination of MeSH and free terms on CRI was performed using PubMed, followed by a double-blind review in order to select a list of candidate best papers to be then peer-reviewed by external reviewers. A consensus meeting between the two section editors and the editorial team was organized to finally conclude on the selection of best papers.

Results: Among the 452 papers published in 2016 in the various areas of CRI and returned by the query, the full review process selected four best papers. The authors of the first paper utilized a comprehensive representation of the patient medical record and semi-automatically labeled training sets to create phenotype models via a machine learning process. The second selected paper describes an open source tool chain securely connecting ResearchKit compatible applications (Apps) to the widely-used clinical research infrastructure Informatics for Integrating Biology and the Bedside (i2b2). The third selected paper describes the FAIR Guiding Principles for scientific data management and stewardship. The fourth selected paper focuses on the evaluation of the risk of privacy breaches in releasing genomics datasets.

Conclusions: A major trend in the 2016 publications is the variety of research on “real-world data” - healthcare-generated data, person health data, and patient-reported outcomes -highlighting the opportunities provided by new machine learning techniques as well as new potential risks of privacy breaches.
Capturing the Patient’s Perspective: a Review of Advances in Natural Language Processing of Health-Related Text
Authors: Gonzalez-Hernandez G. , Sarker A. , O’Connor K. , Savova G.
Published: September 2017

Background: Natural Language Processing (NLP) methods are increasingly being utilized to mine knowledge from unstructured health-related texts. Recent advances in noisy text processing techniques are enabling researchers and medical domain experts to go beyond the information encapsulated in published texts (e.g., clinical trials and systematic reviews) and structured questionnaires, and obtain perspectives from other unstructured sources such as Electronic Health Records (EHRs) and social media posts.

Objectives: To review the recently published literature discussing the application of NLP techniques for mining health-related information from EHRs and social media posts.

Methods: Literature review included the research published over the last five years based on searches of PubMed, conference proceedings, and the ACM Digital Library, as well as on relevant publications referenced in papers. We particularly focused on the techniques employed on EHRs and social media data.

Results: A set of 62 studies involving EHRs and 87 studies involving social media matched our criteria and were included in this paper. We present the purposes of these studies, outline the key NLP contributions, and discuss the general trends observed in the field, the current state of research, and important outstanding problems.

Conclusions: Over the recent years, there has been a continuing transition from lexical and rule-based systems to learning-based approaches, because of the growth of annotated data sets and advances in data science. For EHRs, publicly available annotated data is still scarce and this acts as an obstacle to research progress. On the contrary, research on social media mining has seen a rapid growth, particularly because the large amount of unlabeled data available via this resource compensates for the uncertainty inherent to the data. Effective mechanisms to filter out noise and for mapping social media expressions to standard medical concepts are crucial and latent research problems. Shared tasks and other competitive challenges have been driving factors behind the implementation of open systems, and they are likely to play an imperative role in the development of future systems.
Health Data for Public Health: Towards New Ways of Combining Data Sources to Support Research Efforts in Europe
Authors: Burgun A. , Bernal-Delgado E. , Kuchinke W. , van Staa T. , Cunningham J. , Lettieri E. , Mazzali C. , Oksen D. , Estupiñan F. , Barone A. , Chène G.
Published: September 2017

Objectives: To present the European landscape regarding the re-use of health administrative data for research. Methods: We present some collaborative projects and solutions that have been developed by Nordic countries, Italy, Spain, France, Germany, and the UK, to facilitate access to their health data for research purposes.

Results: Research in public health is transitioning from siloed systems to more accessible and re-usable data resources. Following the example of the Nordic countries, several European countries aim at facilitating the re-use of their health administrative databases for research purposes. However, the ecosystem is still a complex patchwork, with different rules, policies, and processes for data provision.

Conclusion: The challenges are such that with the abundance of health administrative data, only a European, overarching public health research infrastructure, is able to efficiently facilitate access to this data and accelerate research based on these highly valuable resources.
On Contributing to the Progress of Medical Informatics as Publisher
Authors: Haux R. , Geissbuhler A. , Holmes J. , Jaulent M.-C. , Koch S. , Kulikowski C. A. , Lehmann C. U. , McCray A. T. , Séroussi B. , Soualmia L. F. , van Bemmel J. H.
Published: September 2017

May 1st, 2017, will mark Dieter Bergemann’s 80th birthday. As Chief Executive Officer and Owner of Schattauer Publishers from 1983 to 2016, the biomedical and health informatics community owes him a great debt of gratitude. The past and present editors of Methods of Information in Medicine, the IMIA Yearbook of Medical Informatics, and Applied Clinical Informatics want to honour and thank Dieter Bergemann by providing a brief biography that emphasizes his contributions, by reviewing his critical role as an exceptionally supportive publisher for Schattauer’s three biomedical and health informatics periodicals, and by sharing some personal anecdotes. Over the past 40 years, Dieter Bergemann has been an influential, if behind-the-scenes, driving force in biomedical and health informatics publications, helping to ensure success in the dissemination of our field’s research and practice.
Secondary Use and Analysis of Big Data Collected for Patient Care
Authors: Martin-Sanchez F. J. , Aguiar-Pulido V. , Lopez-Campos G. H. , Peek N. , Sacchi L.
Published: September 2017

Objectives: To identify common methodological challenges and review relevant initiatives related to the re-use of patient data collected in routine clinical care, as well as to analyze the economic benefits derived from the secondary use of this data. Through the use of several examples, this article aims to provide a glimpse into the different areas of application, namely clinical research, genomic research, study of environmental factors, and population and health services research. This paper describes some of the informatics methods and Big Data resources developed in this context, such as electronic phenotyping, clinical research networks, biorepositories, screening data banks, and wide association studies. Lastly, some of the potential limitations of these approaches are discussed, focusing on confounding factors and data quality.

Methods: A series of literature searches in main bibliographic databases have been conducted in order to assess the extent to which existing patient data has been repurposed for research. This contribution from the IMIA working group on “Data mining and Big Data analytics” focuses on the literature published during the last two years, covering the timeframe since the working group’s last survey.

Results and Conclusions: Although most of the examples of secondary use of patient data lie in the arena of clinical and health services research, we have started to witness other important applications, particularly in the area of genomic research and the study of health effects of environmental factors. Further research is needed to characterize the economic impact of secondary use across the broad spectrum of translational research.
The IMIA History Working Group: Inception through the IMIA History Taskforce, and Major Events Leading Up to the 50th Anniversary of IMIA
Authors: Kulikowski C. A. , Mihalas G. , Greenes R. A. , Yacubsohn V. , Park H.-A.
Published: September 2017

Background: The 50th Anniversary of IMIA will be celebrated in 2017 at the World Congress of Medical Informatics in China. This takes place 50 years after the International Federation of Information Processing (IFIP) Societies approved the formation of a new Technical Committee (TC) 4 on Medical Information Processing, which was the predecessor of IMIA, under the leadership of Dr. Francois Grémy. The IMIA History Working Group (WG) was approved in 2014 to document and write about the history of the field and its organizations.

Objectives: The goals of this paper are to describe how the IMIA History WG arose and developed, including its meetings and projects, leading to the forthcoming 50th Anniversary of IMIA.

Methods: We give a chronology of major developments leading up to the current work of the IMIA History WG and how it has stimulated writing on the international history of biomedical and health informatics, sponsoring the systematic compilation and writing of articles and stories from pioneers and leaders in the field, and the organization of workshops and panels over the past six years, leading towards the publication of the contributed volume on the 50th IMIA Anniversary History as an eBook by IOS Press.

Conclusions: This article leads up to the IMIA History eBook which will contain original autobiographical retrospectives by pioneers and leaders in the field, together with professional organizational histories of the national and regional societies and working groups of IMIA, with commentary on the main themes and topics which have evolved as scientific and clinical practices have changed under the influence of new insights, technologies, and the changing socio-economic, cultural and professional circumstances around the globe over the past 50 years.
Added Value from Secondary Use of Person Generated Health Data in Consumer Health Informatics
Authors: Hsueh P.-Y. , Cheung Y.-K. , Dey S. , Kim K. K. , Martin-Sanchez F. J. , Petersen S. K. , Wetter T.
Published: September 2017

Introduction: Various health-related data, subsequently called Person Generated Health Data (PGHD), is being collected by patients or presumably healthy individuals as well as about them as much as they become available as measurable properties in their work, home, and other environments. Despite that such data was originally just collected and used for dedicated predefined purposes, more recently it is regarded as untapped resources that call for secondary use.

Method: Since the secondary use of PGHD is still at its early evolving stage, we have chosen, in this paper, to produce an outline of best practices, as opposed to a systematic review. To this end, we identified key directions of secondary use and invited protagonists of each of these directions to present their takes on the primary and secondary use of PGHD in their sub-fields. We then put secondary use in a wider perspective of overarching themes such as privacy, interpretability, interoperability, utility, and ethics.

Results: We present the primary and secondary use of PGHD in four focus areas: (1) making sense of PGHD in augmented Shared Care Plans for care coordination across multiple conditions; (2) making sense of PGHD from patient-held sensors to inform cancer care; (3) fitting situational use of PGHD to evaluate personal informatics tools in adaptive concurrent trials; (4) making sense of environment risk exposure data in an integrated context with clinical and omics-data for biomedical research.

Discussion: Fast technological progress in all the four focus areas calls for a societal debate and decision-making process on a multitude of challenges: how emerging or foreseeable results transform privacy; how new data modalities can be interpreted in light of clinical data and vice versa; how the sheer mass and partially abstract mathematical properties of the achieved insights can be interpreted to a broad public and can consequently facilitate the development of patient-centered services; and how the remaining risks and uncertainties can be evaluated against new benefits. This paper is an initial summary of the status quo of the challenges and proposals that address these issues. The opportunities and barriers identified can serve as action items individuals can bring to their organizations when facing challenges to add value from the secondary use of patient-generated health data.
IMIA Accreditation of Biomedical and Health Informatics Education: Current State and Future Directions
Authors: Jaspers M. W. , Mantas J. , Borycki E. , Hasman A.
Published: September 2017

Objectives: The educational activities initiated by the International Medical Informatics Association (IMIA) have had global impacts and influenced national societies and local academic programs in the field of Biomedical and Health Informatics (BMHI). After the successful publication and dissemination of its educational recommendations, IMIA launched an accreditation procedure for educational programs in BMHI. The accreditation procedure was pilot tested by several BMHI academic programs in different countries and continents to obtain a global perspective.

Methods: This paper presents an overview of IMIA quality assurance and accreditation procedures along with feedback on issues and problems which emerged during the pilot.

Results: It appears that IMIA quality assurance and procedures worked quite well in different countries of Europe, the Middle East, South America, and Asia. These first experiences provided adequate information for adapting, modifying, and optimizing the procedures and finally for the planning of future activities.

Conclusions: IMIA accreditation framework comprises a single set of standards that apply at various levels to both academic and professional BMHI programs. The pilot phase confirmed the robustness and generalizability of quality assurance standards and associated procedures on which IMIA accreditation is based at an international level.
Surgical Emergencies in Intestinal Venous Malformations
Authors: Bueno Alba , De La Torre Carlos , Cerezo Vanesa , Rebolledo Bryant , Cervantes Manuel , Dore Mariela , Gomez Javier , Santamaria Manuel , Martinez Leopoldo , Lopez-Gutierrez Juan , Romo Muñoz Martha
Published: September 2017

Background Venous malformations (VMs) can occur in any part of the body; however, the gastrointestinal tract is a frequent location. These are usually asymptomatic, thus, representing a challenge to diagnosis. Intestinal location of VMs can be associated with severe complications that ultimately require an emergency surgery. Our aim was to analyze all patients with an intestinal VM with special focus on those who required emergency surgery.

Materials and Methods A retrospective study of patients presenting complication caused by intestinal VM was performed. Clinical records, associated anomalies, physical findings, and treatment were assessed.

Results Twenty-one patients had a diagnosis of intestinal VM, 16 (76%) were associated to blue rubber bleb nevus syndrome (BRBNS) and 5 (24%) were isolated. Only four (19%) of the total cases presented an episode of acute abdomen with hemodynamic instability that required an emergency surgery. Findings included two gastrointestinal bleedings, one volvulus, and one intussusception of small bowel. All patients underwent an uneventful recovery and are presently doing well.

Conclusion Intestinal VM can be challenging to diagnose in emergency situations, such as gastrointestinal situation or acute abdomen. The complications associated with it must be kept in mind, regardless of its low incidence.
Outcomes of Esophageal Replacement: Gastric Pull-Up and Colonic Interposition Procedures
Authors: Sloan Keren , Morandi Anna , Lakshminarayanan Bhanumathi , Cox Sharon , Millar Alastair , Numanoglu Alp , Lakhoo Kokila , Bradshaw Catherine
Published: September 2017

Aim No consensus exists about the optimal surgical technique for esophageal replacement. This study reports the surgical outcomes for the gastric pull-up and the colonic interposition procedures.

Materials and Methods A retrospective review of children undergoing esophageal replacement surgery between January 2001 and June 2015 across four different pediatric surgery centers was conducted. Data collected included indications, epidemiology, surgical technique, complications, and outcomes. Patients were divided into group A, those that had a gastric pull-up procedure and group B, those that had a colonic interposition procedure.

Results In total, 50 patients were included; 29 in group A and 21 in group B. Indications included esophageal atresia, caustic ingestion, and infective esophageal stricture. The median age at the time of surgery was 13 months. The mean length of follow-up was 5.2 years. Three patients died giving a mortality rate of 6%; 2 in group A and 1 in group B.

In both groups, early postoperative complications included infective complications, such as wound infections, sepsis, and pneumonia (11), anastomotic leak (7), and respiratory complications (7). Late complications included adhesive bowel obstruction (2), anastomotic strictures (4), redundancy (1), and jejunostomy problems (1). Septic complications and anastomotic strictures occurred more frequently in group B. Further surgery was needed in eight patients; this was significantly higher in group B. Full oral feeding was achieved within 6 months in 91.5%.

Conclusion The gastric pull-up and colonic interposition have comparable mortality and outcomes. The colonic interposition was associated with a higher rate of early septic complications, anastomotic strictures, and need for further surgery.
Centralization of Pediatric Surgical Procedures in the United Kingdom
Authors: Durkin Natalie , Davenport Mark
Published: September 2017

The NHS provides more than 98% of all surgical procedures in infants and children in the United Kingdom through a comprehensive network of secondary (typically for the general surgery of childhood) and tertiary (specialist neonatal and specialist pediatric surgery) centers [n = 22]), typically located within large conurbations. It was originally envisaged that these specialized centers would be able to provide the full range of surgical interventions (aside from organ transplantation). However, there has been a trend toward centralization of some key procedures, previously thought to be within general neonatal surgery.

The architype for centralization is the management of biliary atresia (BA). Since 1999, within England and Wales, this has been exclusively managed in three centers (King's College Hospital, London; Birmingham Children's Hospital and Leeds General Infirmary). All of these provide facilities for the diagnosis of BA, primary surgical management (Kasai portoenterostomy), and liver transplantation if required. The case for centralization was made by rigorous national outcome analysis during the 1990s showing marked disparity based on case volume and driven by parents' organizations and national media. Following centralization, national outcome data showed improvement and provided a benchmark for others to follow.

The management of bladder exstrophy was later centralized in England and Wales, albeit not based on strict outcome data, to two centers (Great Ormond Street, London and Royal Manchester Children's Hospital).
The Incidence of Chromosomal Aberrations in Prenatally Diagnosed Isolated Agenesis of the Corpus Callosum
Authors: Rüland Anna , Gloning Karl-Philipp , Albig Matthias , Kagan Karl-Oliver , Hammer Rüdiger , Schälike Michael , Berg Christoph , Gembruch Ulrich , Geipel Annegret
Published: September 2017

Purpose To establish the prevalence of chromosomal aberrations in fetuses with an apparently isolated agenesis of the corpus callosum (ACC) on prenatal ultrasound.

Materials & Methods This was a retrospective study of complete isolated ACC at the time of ultrasound evaluation with respect to karyotype information. Within this group, a subgroup with non-malformation minor abnormalities, such as a single umbilical artery (SUA), polyhydramnios or fetal growth restriction (FGR), was investigated.

Results Complete ACC was diagnosed in 343 cases. Of them, 143 (41.6 %) were isolated, with 16 fetuses showing additional minor findings. In 76.2 % (109/143) karyotyping was performed. Additional array CGH analysis was performed in 7.7 % (11/143). Chromosomal aberrations were found in 4.6 % (5/109) overall, in 3.1 % (3/98) of those without any additional sonographic findings (all represented mosaic trisomy 8) and in 18.2 % (2/11) of those with minor abnormalities. The prevalence of pathogenic submicroscopic copy number variant (CNV) was 9 % (1/11).

Conclusion Fetal karyotyping is recommended in ACC, as trisomy 8 mosaicism should be considered despite otherwise unremarkable ultrasound. The role of novel techniques such as array CGH and its implication has to be explored in prospective studies.
How Do Patients Experience Individualized Medicine? A Qualitative Interview-based Study of Gene Expression Analyses in the Treatment of Breast Cancer
Authors: Schleidgen Sebastian , Thiersch Sandra , Wuerstlein Rachel , Marckmann Georg
Published: September 2017

Introduction In recent years, the hopes and expectations associated with so-called individualized medicine have been the subject of intense debate as has the medical potential of this approach. Questions about the uses of gene expression analyses for decisions on adjuvant systemic treatment options for patients with breast cancer have played a prominent role in this debate. There are a number of empirical studies on the effect of gene expression tests on the therapy decisions of physicians and the potentially conflicted decisions for patients. Very little attention has been paid to how patients perceive such approaches, the extent to which they feel included in the therapy decision, and the expectations they associate with such an approach.

Material and Methods Using qualitative explorative interviews, the study looked at how well patients with breast cancer understood the individualized treatment approaches and examined patientsʼ experiences and expectations with regard to gene expression analyses. The sample consisted of 8 patients who were diagnosed with primary hormone receptor-positive, HER2-negative breast cancer between 2013 and 2014 and who underwent gene expression analyses as part of their adjuvant therapy planning.

Results Patients were found to have a quite realistic view of the benefits of gene expression analyses, although it also became clear that the treatment could also raise false hopes. The statements by the interviewed women also illustrated the necessity of continuing to explore the possibilities and limits to joint decision-making in such complex medical contexts as individualized molecular genomic medicine. And finally, the interviews reflected the hope for individualized treatment in the broadest sense of the word.

Conclusion The results of the study highlight the challenge of taking psychosocial aspects of medical treatment sufficiently into consideration, given the ever increasing options for molecular genomic individualization.