bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of creativity in nursing education
Authors: Hamdan Sameer , Isik Burcin , Jallad Samar Thabet
Published: September 2019

Nowadays, the world has changed from a production source to a services-driven force; there are new challenges and shifts towards meaningful learning, together with rapid technological, socio-economic and environmental changes which call for a specific educational approach that learners need to acquire meaningful knowledge while encouraging them to utilise their knowledge in learning process to develop lifelong learning skills in order to prepare them for a complex future. Creativity in nursing education is an essential competence in fostering nursing learners; as both creative and critical thinking skills are needed to identify issues and create critical solutions to improve learners’ cognitive attributes and reflection and engagement in learning by developing assessment strategies and inspiring internal motivation for lifelong learning during various teaching activities. Therefore, nursing programmes must prepare nurses who can successfully perform in an environment that demands innovative problem-solving. In this context, this paper reviews the impacts of creativity in nursing education.

 

Keywords: Nursing education, creativity, creative thinking, strategies of creativity
Desarrollo de la Investigación en Razonamiento Inferencial Informal
Authors: A. Jesús G Lugo , G. Jaime I García , H. Blanca R. Ruíz
Published: September 2019

En este trabajo se informa sobre una Revisión Sistemática de la Literatura (SLR) basada en la búsqueda automatizada en WoS, Scopus, MathEduc y, adicionalmente, en el SERJ de forma manual. El objetivo es proporcionar un panorama general del desarrollo de la investigación en el Razonamiento Inferencial Informal (RII) para investigadores en Educación Estadística. De los resultados de la búsqueda, se seleccionaron 57 estudios primarios, identificando el énfasis, el contexto y la metodología de las investigaciones; así como los autores y artículos más citados. Se encontró que en los últimos años, el desarrollo de la investigación en RII se ha enfocado en la modelación y el uso de software dinámico; los resultados están dirigidos a investigadores y profesores. Cabe destacar que los artículos con mayor impacto, en cuestión del número de citas o promedio de citas por año, son aquellos estudios previos que se consideran íconos dentro de la Educación Estadística, ya que proponen un marco de trabajo enfocado en la integración de conceptos o ideas estadísticas como un sistema para el desarrollo del RII.

Abstract

This paper reports on a Systematic Literature Review (SLR) based on the automated search in WoS, Scopus, MathEduc and, additionally, manually in SERJ. The aim is to provide an overview of the development of research in Informal Inferential Reasoning (IIR) for researchers in Statistical Education. From the search results, 57 primary studies were selected, identifying the emphasis, context and methodology; as well as the most cited authors and articles. It was found that in recent years, the development of research in the IIR has focused on the modeling and use of dynamic software; the results are aimed at researchers and professors. It should be noted that the articles with the greatest impact, in terms of the number of citations or average citations per year, are those previous studies that are considered essential within Statistical Education, since they propose a framework focused on integration of concepts or statistical ideas as a system for the development of the RII
La Enseñanza determinista de la probabilidad
Authors: B. Geovanni Sanabria
Published: September 2019

El presente trabajo analiza las respuestas de docentes en formación, que ya cursaron un curso sobre probabilidad y son estudiantes del Instituto Tecnológico de Costa Rica, en un test de  situaciones problema de probabilidad con el fin de valorar el manejo que hacen de la aleatoriedad. En las respuestas se evidencia que algunos: no saben hacer explícito el espacio muestral ni la experiencia aleatoria, descuidan las hipótesis que se necesitan para utilizar la probabilidad como un modelo y dan respuestas deterministas a situaciones aleatorias, es decir piensan que hay una única respuesta correcta. ¿Será que se enseña la probabilidad de forma determinista?

Abstract

This paper analyzes the responses of teachers in training, who have already taken a course on probability and are students of the Technological Institute of Costa Rica, in a test of probability problem situations in order to assess the handling they make of randomness. The answers show that some do not know how to make explicit the sample space or the random experience, neglect the hypotheses that are needed to use probability as a model and give deterministic answers to random situations. Could it be that probability is taught in a deterministic way?
Isolated Non-16/18 High-Risk Human Papillomavirus Cervical Infection: Re-Evaluation After One Year
Authors: Vargas Sara , Valente Maria Pulido , Almeida Margarida Mendes de , Neves Joaquim , Calhaz-Jorge Carlos
Published: September 2019

Introduction: High-risk human papillomavirus cervical infection is currently a well-established cause of cervical cancer. However, only a few women with persistent infections will develop cervical precancerous and malignant lesions. Approximately 20% of all cervical cancers are attributable to non-16/18 serotypes. This study aims to evaluate the results of our clinical approach to women with this infection.Material and Methods: We conducted an observational and prospective study from September 2012 to September 2017, which included women with isolated non-16/18 high-risk human papillomavirus infection (with normal cytology). After re-evaluation, two groups were compared: women with spontaneous regression of the infection and women with persistent infection. Clinical and demographic data were analysed as well as the rate of progression to precancerous and malignant lesions.Results: We included 165 women, of which 121 were re-evaluated with co-test at least one year later. After re-evaluation, 13.2% of women revealed precancerous lesions but only two (1.7%) of them presented high-grade squamous intraepithelial lesions. Sixty-seven women (55.4%) showed spontaneous regression of the infection and 54 women (44.6%) maintained it. Women with persistent infection developed more precancerous lesions (27.8%; p < 0.001) and high-grade squamous intraepithelial lesions (3.7%; p < 0.001). There was also an association between persistent infection and postmenopausal status.Discussion: Human papillomavirus 16/18 cervical infection is associated with higher risk of cervical cancer when compared with other serotypes.Conclusion: Re-evaluation with co-test one year after the diagnosis of isolated non-16/18 human papillomavirus infection seems to be a reasonable approach.
Chronic Pain and Multimorbidity: Comment on "Chronic Pain Education in Portugal: Perspectives from Medical Students and Interns”
Authors: Prazeres Filipe
Published: September 2019

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Gestão internacional de pessoas: uma análise bibliométrica da produção científica em periódicos brasileiros, 2000-2017
Authors: Athayde André Luiz Mendes , Silva Luana Stephanie Oliveira
Published: September 2019

O presente artigo teve como objetivo analisar a produção científica em 32 periódicos brasileiros na área da Administração, restringindo-se àqueles que estão inseridos nos estratos superiores conforme classificação Qualis da Coordenação de Aperfeiçoamento de Pessoas de Nível Superior (CAPES), publicados entre o período de 2000 a 2017, acerca da temática Gestão Internacional de Pessoas. Empregou-se uma análise bibliométrica que utilizou indicadores para mensurar os padrões demográficos, metodológicos e temáticos de 37 artigos selecionados. Os resultados apontaram gradualmente o desenvolvimento de estudos a respeito do tema, porém apresentando algumas deficiências, principalmente em relação à institucionalização da pesquisa no Brasil.
The Role of Fun at Work towards Job Satisfaction of Employee with Work Engagement as Mediator
Authors: Permatasari Yan Ayu , Riani Asri Laksmi
Published: September 2019

The purpose of this study is to examine the effect of fun at work on job satisfaction with work engagement as a mediation variable. Specifically, this study is intended is to find out the relationship between fun at work and work engagement, fun at work and work satisfaction, and fun at work and work satisfaction mediated by work engagement. Data were collected through surveys and conducted by distributing questionnaires to the company. The sampling technique used is a saturation sampling method, which all members of the population were used as the sample. The sample consisted of 65 respondents. The results of this study suggests that fun at work significantly affects work engagement. In addition, work involvement indirectly mediates between fun at work and job satisfaction. This phenomenon possibly can occur because a fun workplace can stimulate a good mood and excitement for employees in doing their job.
The association between statin-use and diet, exercise, and perceptions of high cholesterol in urban and semi-urban Nigerians: a cross-sectional study.
Authors: Coker Joyce F , Hill Kate M , Otu Akaninyene A , House Allan
Published: September 2019

Background
The rise of cardiovascular diseases in sub-Saharan Africa strains fragile healthcare systems. Cardiovascular disease prevention involves the use of prophylactic medications like statins and the adoption of healthy lifestyle choices. However, the nature of the relationship between statin-use and the adoption of healthy lifestyle choices remains unclear. This study is the first to examine whether there is a relation between statin-use, the adoption of a low-fat diet and healthy exercise behaviours, and the way Nigerians diagnosed with hyperlipidaemia think about high cholesterol as a risk factor for cardiovascular disease.
Methods
This cross-sectional study was conducted in an urban site and a semi-urban site in Nigeria. Questionnaires were used to compare the dietary and exercise behaviours; perceptions of high cholesterol; and perceived future risk of cardiovascular disease of 78 statin users and 70 non-statin users.
Results
The majority (69%) of participants reported that they had adopted a low-fat diet. However, 80% participants were classified as inactive/moderately inactive and statin users were significantly less active than non-statin users (86% of statin users inactive/moderately inactive vs 74% of non-statin users, X2 =3.852, p=0.05).
A logistic regression model found that odds of adopting a low-fat diet was 5 times greater in participants recruited from the urban research site (95% CI=1.7 to 12.5, p=0.003) and increased as reported perceived statin control of high cholesterol increased (OR=2.33, 95% CI=1.16 to 4.69, p=0.018).
Conclusions
The odds of adopting a low-fat diet increased as statin control perceptions increased - suggesting that statin-use and the adoption of healthy dietary choice were thought to work in unison to manage high cholesterol. Urban-dwellers were more likely to have adopted healthy dietary choices and to think about adopting exercise choices than semi-urban dwellers. This demonstrates a growing awareness of negative future impacts of Westernised lifestyle behaviours in urban areas and the need for public health interventions in semi-urban areas to raise awareness and facilitate the adoption of healthy lifestyle choices in order to curtail the rise of cardiovascular disease in Nigeria.
Lived Experiences Of Pregnancy Among Women With Sickle Cell Disease Receiving Care At Mulago Hospital: A Qualitative Study
Authors: TUMWESIGE KENNETH , Imelda Namagembe , Herbert Kayiga , Deogratias Munube , Joseph Rujumba
Published: September 2019

Background Women with sickle cell disease in Mulago National Referral Hospital face challenges when they become pregnant and they receive the same care as all other high risk pregnant women who come to the hospital. This study explored the lived experiences of pregnancy among women with sickle cell disease receiving care at Mulago National Referral Hospital.Methods This was a qualitative phenomenological study conducted on 15 participants who were women with sickle cell disease with the experience of pregnancy. In-depth audio recorded interviews were conducted to collect data from women who were pregnant at time of study or had ever been pregnant aged 16 to 38 years of age with sickle cell disease. Recorded data was transcribed and analyzed using content thematic approach.Results This study revealed that pregnant women with sickle cell disease faced both negative and positive health care experiences and individual lived experiences of pregnancy. The few positive individual lived experiences were joy of motherhood and giving birth to child free of sickle cell disease whereas the negative individual lived experiences reported were recurrent painful crises, pregnancy loss, premature delivery, stigma and discouragement, relationship discord and desertion by spouse. There were few positive healthcare experiences reported in this study which included: dedicated care and support from health workers, referral to specialist services, support from their male partners and the negative healthcare experiences reported were delay to get medical assistance, informal hospital charges, unsatisfactory care, and advocacy for caesarian section Vs normal delivery.Conclusion Pregnant women with sickle cell disease lived with great expectation and in fear of being further weakened by the disease. Their experiences were in general negative at both individual, social and health system levels.
Evaluation Of Online Development Examinations Of Infectious Diseases And Clinical Microbiology (IDCM) Expertise Students
Authors: Kaygusuz Türkkan , Karabay Oğuz
Published: September 2019

Background: Formative examinations are required to monitor the development of research assistants in the field of Infectious Diseases and Clinical Microbiology. However, the preparation, conduct and evaluation of these exams also require especial features and experience. In this study, it is aimed to review the experiences obtained in the evaluation exams of research assistants conducted by the education commission (EMEK) in the field of IDCM specialization.
Methods: There are two online exams per year for research assistants in the IDGM field. In this study, the examinations between 2014-2018 were evaluated. The validity and reliability analyzes for each exam were performed and the difficulty and discrimination indexes of the questions were calculated. The topics with the least correct answers were determined.
Results: Over the years, an increase in the number of research assistants was observed. The internal consistency coefficient of the exams was the lowest of the cronbach alpha value of 0,69 and the highest of 0,92. The mean score of the exam was over 70. Some of the questions needed to be reviewed and corrected. Although clinically rare diseases and basic microbiology questions have been answered less frequently, the rate of responding to diseases that are frequently seen in the clinic was higher.
Conclusion: Online examinations facilitate broad-based measurement and evaluation at national level. With the increase of our online exam experience, we found that there are still parts to be improved.
Keywords: Online examination, Expertise students, Development exams, Measurement and evaluation
Exploring the Role of Project Governance and Stakeholder Management in Public Sector Infrastructure Projects
Authors: Ismail Ishak  Ismail , Khan Asadullah  Khan , Waris Muhammad  Waris , Haron Hasnah  Haron , H. Simamora Bachtiar  H. Simamora
Published: September 2019

In developing countries, governance of public sector projects is becoming increasingly more complex due to the varying nature of stakeholders and their expectations from the government to address their interest. As a result, policymakers and sponsoring agencies are more focusing on stakeholder management to ensure smooth execution, high performance and achieving desired outcomes. This study has conducted a systematic appraisal of the relevant literature to explore the thematic discussions on the role of project governance and stakeholder management in public sector infrastructure projects of Pakistan. The analysis reveals that project governance and stakeholder management is not widely been discussed in the Pakistan specific studies. Therefore, this research proposes project governance and stakeholder management as key concerns of government decision-making strategies.
Knowledge Retention Strategy Evaluation & Knowledge Management System Design at Plastic Injection Company in Indonesia
Authors: Adi Anggoro Leo  Adi Anggoro , H. Simamora Bachtiar  H. Simamora
Published: September 2019

The potential of knowledge loss when an employee retires or resigns is high at PT. XYZ a plastic injection company in Indonesia. Therefore, it is required to evaluate their knowledge retention strategy (KRS) and developing a knowledge management system (KMS). The evaluation of KRS using Organizational Knowledge Retention Framework developed by David DeLong and for designing KMS model using the 10-Step KM Roadmap method developed by Amrit Tiwana. Through a well-developed KRS and KMS design model, PT. XYZ can overcome the problem of losing the knowledge that occurs because employees retire or resign.
LIMITES E POTENCIALIDADES DE MATERIALIZAÇÃO DO CURRÍCULO INTEGRADO: UMA ANÁLISE DOS PLANOS DE ENSINO E DIÁRIOS DE CLASSE
Authors: Pasqualli Roberta , Da Silva Vosnei , Da Silva Adriano Larentes
Published: September 2019

O presente artigo tem por objetivo identificar e compreender os limites e potencialidades de materialização da integração curricular no cotidiano dos cursos técnicos integrados nos cursos Técnico em Informática Integrado ao Ensino Médio, Câmpus Chapecó e Técnico em Agroindústria Integrado ao Ensino Médio, Câmpus São Miguel do Oeste, ambos ofertados pelo Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina – IFSC. O foco da análise foram treze Planos de Ensino e dez Diários de Classe dos componentes curriculares Oficina de Integração e Projeto Integrador, do primeiro e segundo semestres de 2015. Os resultados da análise mostram a complexidade do trabalho pedagógico no contexto do currículo integrado e apontam diferentes formas de materialização da integração nas Oficinas de Integração e nos Projetos Integradores. De forma geral, os Planos de Ensino e Diários de Classe apresentam-se preponderantemente como instrumentos jurídicos e formais, não se configurando como instrumentos de planejamento coletivo e de síntese das ações e finalidades propostas. Por outro lado, as análises realizadas também revelam as intencionalidades, as potencialidades e a materialidade das experiências com os Projetos Integradores e as Oficinas de Integração nos cursos pesquisados.

Palavras-Chave: Currículo Integrado, Planos de Ensino, Diário de Classe.
A PERSPECTIVA DO PROFESSOR NA EDUCAÇÃO AMBIENTAL
Authors: Uhmann Rosangela Inês Matos , Follmann Luciane
Published: September 2019

O presente artigo aborda algumas concepções e práticas pedagógicas sobre a Educação Ambiental (EA) discutidos num processo de formação continuada entre licenciandos, formadores e professores de escola. Os dados aqui apresentados foram construídos mediante análise das falas respectivo a um dos encontros dos Ciclos Formativos em Ensino de Ciências, o qual tratou das: “Questões controversas em uma perspectiva crítica da Educação Ambiental que podem ser abordadas em sala de aula”. Além dos aspectos documentais no estudo das Leis ambientais foi indiciado o uso de imagens (cartuns) para trabalhar com as questões socioambientais em discussão de forma controversa na Educação Básica. Portanto, é na formação continuada, a exemplo dos encontros formativos que se percebe a problemática no desenvolvimento das ações de EA, tema controverso emergente e urgente, o que exige iniciativas de participação, conhecimento e responsabilidade principalmente entre os sujeitos escolares de forma contínua, integrada e adequada à preservação do nosso ambiente.
O TRABALHO DO SERVIÇO SOCIAL E A ARTICULAÇÃO COM AS DIMENSÕES TEÓRICO-METODOLÓGICA, ÉTICO-POLÍTICA E TÉCNICO-OPERATIVA
Authors: Rodrigues Verônica Da Mata Huebra , Lopes Noêmia de Fátima Silva
Published: September 2019

Este artigo busca responder indagações sobre o trabalho profissional do serviço social de um município da Zona da Mata Mineira. O estudo fundamentou-se na seguinte questão: os desafios do trabalho do Serviço Social têm fortalecido sua prática em articulação com as dimensões teórico-metodológica, ético- política e técnico-operativa? O principal objetivo é analisar o trabalho do profissional e sua articulação com as dimensões teórico-metodológica, ético-política e técnico-operativa. A pesquisa de caráter exploratório orientou-se pelo método crítico-dialético e, como instrumento metodológico, utilizou-se da pesquisa documental e do estudo de caso com entrevista estruturada. Após estudo, concluiu-se  que as desigualdades existentes no processo de desenvolvimento do país têm sido fruto de suas particularidades históricas, recriando a herança patrimonialista, na qual se atualizam marcas persistentes e, ao mesmo tempo, transformando-as no contexto de mundialização do capital sobre a hegemonia financeira. Diante desse contexto macro-histórico, o profissional de serviço social apresenta dificuldades em articular as dimensões da profissão em sua prática, visto que existe um acúmulo de demandas e uma redução de recursos humanos, bem como recursos técnicos, o que leva a reprodução de uma prática conservadora, voltada para o imediatismo.
CLIMA ORGANIZACIONAL: UMA ANÁLISE ANCORADA NAS TEORIAS DA MOTIVAÇÃO HUMANA
Authors: Santos Alciares Mello dos , Souza Reginaldo Adriano de , Ventura Rita de Cássia M. de O.
Published: September 2019

A política de interiorização do ensino tem provocado uma grande oferta de empregos públicos no interior do Brasil, desenhando organizações miscigenadas, o que pode comprometer o clima e a motivação organizacionais. Este trabalho tem por objetivo a análise do clima organizacional de uma dessas unidades, à luz de duas teorias motivacionais oriundas da década de 1950: a Teoria das Necessidades de Maslow e a Teoria dos Dois Fatores de Herzberg. O trabalho, de caráter predominantemente quantitativo, faz uma abordagem descritiva do clima percebido na escola. De acordo com a pesquisa e analisando a teoria de Maslow, há necessidades de nível superior e inferior não satisfeitas. No nível superior, embora haja um sentimento de orgulho e realização por trabalhar no campus, percebe-se que o reconhecimento e a atenção esperados não são atendidos. No nível inferior, apesar dos salários, benefícios e fatores de segurança parecerem satisfatórios, as necessidades sociais e fisiológicas são comprometidas pelos deslocamentos realizados pelos colaboradores. Além disso, não há identificação dos servidores com o município. Analisando a teoria de Herzberg, os problemas de relacionamento com a chefia imediata comprometem os fatores higiênicos, ao passo que os fatores motivacionais são identificados no prazer pelo conteúdo do trabalho, além do orgulho que os servidores sentem em relação à empresa e à profissão. A pesquisa aponta resultados importantes que podem colaborar para um melhor desempenho da organização, mas não permite um diagnóstico estático sobre o clima da empresa, já que esse é mutável e totalmente dependente das condições psicológicas do indivíduo.
Assessment of Embodied Energy/ U-Value in Historic Buildings of Karachi-Pakistan
Authors: Laiq Wajeeha
Published: September 2019

The benefits of reusing historic and existing buildings versus those of constructing new buildings are frequently discussed considering economic, cultural, and design values. If those discussions are expanded to include environmental impact, one must address the topic of embodied energy. Due to the recent focus on sustainable construction practices; conservationists have explored the benefits of building conservation in relation to embodied energy calculations. Such studies are popular in international market and became important ground for expanding restoration practices. In our local context it is comparatively a newer domain.Different methodologies have been devised by Advisory Council for Historic Preservation (ACHP), in year 1979, for assessing the embodied energy calculations in historic structures. For performing the respective study, inventory model of assessment has adopted. The focus of this study is “to provide practical guidance on how to calculate embodied energy/ u-value in historic structures of Karachi and promote the concept of adaptive reuse from the environmental perspective”. “If more widely and comprehensively used, embodied-energy assessment can be a benefit to preservation and sustainability advocates alike.”Mike Jackson
Research on Reconstruction Design of Exterior Wall Materials and Structures of Industrial Architectural Heritage
Authors: Wu Yanming , Zhou Qi
Published: September 2019

With the advent of the post-industrial era, China’s traditional industrial industry has gradually declined or transformed, leaving a large number of industrial buildings abandoned and idle. A majority of these existing industrial building heritages were built with original facade design, which cannot meet the requirements of the time and no longer fits into the new urban interface. From the perspective of language relationship in architecture, building skin and building space are two vital interdependent elements, and the study of building materials as a carrier has a significant impetus to the exploration of building skin. Therefore, the external wall material has naturally become an important factor directly related to the design and performance of the renovation of the industrial building heritages. Its performance and form largely influence or determine the possible ways and means of the transformation of the heritage facades. How should material performance be used to preserve the historical imprint of industrial heritage while conforming to contemporary aesthetics? What are the rules of material performance in the renovation of industrial buildings? These are the issues that needs to be considered and studied in the transformation of industrial building heritage.This paper studies the exterior wall materials and structures in the renovation of industrial building heritage facades, and uses reconstruction theory as a methodology to sort out effective strategies and methods for the material performance of industrial building heritage facade renovation. First it summarizes and elaborates the classification and performance characteristics of the materials of heritage facades as well as the principles and methods of facades transformation. Later it focuses on the practice and development of the renovation of facades in China’s industrial building heritages, taking the reform practice of Nanjing Hutchison Factory as an example. Combing the analysis and summary of the practical project with the theory, this paper helps improve the theoretical system of architectural skin materials within the scope of architectural design theory, summarizes the design concepts consistent with the current view, and conclude the corresponding architectural skin design strategy and methods.
Preservation Laws: Saving Modern Egyptian Architectural Integrity
Authors: Hamdy Mennatallah , Ibrahim Doha
Published: September 2019

Egyptian cities have witnessed a variety of impeccable architecture throughout centuries of civilization, which enriched the Egyptian society. Constantly rising to the discussion is a question of what constitutes value to architecture of different times. It is important to regard heritage conservation as a synthetic, complex topic that is open for interpretations and judgment. While some antiquities are protected by law, it is apparent how modern heritage is a matter of ambiguity when it comes to preservation and conservation efforts. Until the mid-19th century, architectural heritage was primarily concerned with the preservation of monumental architecture. Theorists like John Ruskin and Le-Duc were largely exploring the authentic expression of materials in architecture, establishing the foundation, that Cesare Brandi would later build on, that conservation authenticity is not limited to age, rather includes material, style and structure.It is appropriate to regard heritage buildings as capital assets, with a potential to raise fluxes of services over time. However, not only Cairo, but Egypt has been losing much of its valuable modern heritage; thus its identity in the process.This paper focuses on Egypt's modernist architecture, discussing the rise of modernism and its introduction to the Egyptian cultural scene while reflecting on the current cultural detachment from such heritage and the current tendency towards. It, also, explores the rise of Egyptian modernism as a national style that reflects social and economic prosperity, in contrast to its rise in the west primarily advocating minimalism, functionalism and social equality.In comparing Egyptian laws to international charters on heritage preservation; in particular modern heritage, case studies are used to explore the consequences. The research concludes by suggesting measures and acts that can, directly and indirectly, affect the decision-making process, as well as support efforts of preservation of Egypt's modern heritage.
Design of Rhenium Compounds in Targeted Anticancer Therapeutics
Authors: Collery Philippe , Desmaele Didier , Vijaykumar Veena
Published: September 2019

Background:

Many rhenium (Re) complexes with potential anticancer properties have been synthesized
in the recent years with the aim to overcome the clinical limitations of platinum agents. Re(I) tricarbonyl
complexes are the most common but Re compounds with higher oxidation states have also been investigated, as
well as hetero-metallic complexes and Re-loaded self-assembling devices. Many of these compounds display
promising cytotoxic and phototoxic properties against malignant cells but all Re compounds are still at the stage
of preclinical studies.

Methods:

The present review focused on the rhenium based cancer drugs that were in preclinical and clinical
trials were examined critically. The detailed targeted interactions and experimental evidences of Re compounds
reported by the patentable and non-patentable research findings used to write this review.

Results:

In the present review, we described the most recent and promising rhenium compounds focusing on their
potential mechanism of action including, phototoxicity, DNA binding, mitochondrial effects, oxidative stress
regulation or enzyme inhibition. Many ligands have been described that modulating the lipophilicity, the luminescent
properties, the cellular uptake, the biodistribution, and the cytotoxicity, the pharmacological and toxicological
profile.

Conclusion:

Re-based anticancer drugs can also be used in targeted therapies by coupling to a variety of biologically
relevant targeting molecules. On the other hand, combination with conventional cytotoxic molecules, such
as doxorubicin, allowed to take into profit the targeting properties of Re for example toward mitochondria.
Through the example of the diseleno-Re complex, we showed that the main target could be the oxidative status,
with a down-stream regulation of signaling pathways, and further on selective cell death of cancer cells versus
normal cells.
Chitooligosaccharides as Antibacterial, Antibiofilm, Antihemolytic and Anti-Virulence Agent against Staphylococcus aureus
Authors: Khan Fazlurrahman , Lee Jang-Won , Pham Dung T.N. , Kim Young-Mog
Published: September 2019

Background:

Staphylococcus aureus nosocomial infections with a high mortality rate in
human and animals have been reported to associate with bacterial biofilm formation, along with the secretion
of numerous virulence factors. Therefore, the inhibition of biofilm formation and attenuation of
virulence determinants are considered as a promising solution to combat the spread of S. aureus infections.
Modern trends in antibiofilm therapies have opted for the active agents that are biocompatible,
biodegradable, non-toxic and cost-effective. Owning the aforementioned properties, chitosan, a natural
N-acetylated carbohydrate biopolymer derived from chitin, has been favorably employed. Recently, the
chitosan structure has been chemically modified into Chitooligosaccharides (COS) to overcome its
limited solubility in water, thus widening chitosan applications in modern antibiofilm research. In the
present study, we have investigated the antibacterial, antibiofilm and anti-virulence activities against S.
aureus of COS of different molecular weights dissolved in neutral water.

Methods:

The study of bactericidal activity was performed using the micro-dilution method while the
biofilm inhibition assay was performed using crystal-violet staining method and confirmed by scanning
electron microscopic analysis. The inhibition of amyloid protein production was confirmed by
Congo Red staining.

Results:

Results showed that low molecular weight COS exhibited bactericidal activity and reduced the
bacterial amylogenesis, hemolytic activity as well as H2O2 resistance properties, while slightly inhibiting
biofilm formation. The present study provides a new insight for further applications of the water-soluble
COS as a safe and cost-effective drug for the treatment of S. aureus biofilm-associated infections.

Conclusion:

Reducing the molecular weight of chitosan in the form of COS has become an effective
strategy to maintain chitosan biological activity while improving its water solubility. The low molecular
weight COS investigated in this study have effectively performed antibacterial, antibiofilm and antivirulence
properties against S. aureus.
Partial Reprogramming As An Emerging Strategy for Safe Induced Cell Generation and Rejuvenation
Authors: Lehmann Marianne , Canatelli-Mallat Martina , Chiavellini Priscila , Cónsole Gloria M. , Gallardo Maria D. , Goya Rodolfo G.
Published: September 2019

Background:

Conventional cell reprogramming involves converting a somatic cell line into induced
pluripotent stem cells (iPSC), which subsequently can be re-differentiated to specific somatic cell types.
Alternatively, partial cell reprogramming converts somatic cells into other somatic cell types by
transient expression of pluripotency genes thus generating intermediates that retain their original cell
identity, but are responsive to appropriate cocktails of specific differentiation factors. Additionally,
biological rejuvenation by partial cell reprogramming is an emerging avenue of research.

Objective:

Here, we will briefly review the emerging information pointing to partial reprogramming as
a suitable strategy to achieve cell reprogramming and rejuvenation, bypassing cell dedifferentiation.

Methods:

In this context, regulatable pluripotency gene expression systems are the most widely used
at present to implement partial cell reprogramming. For instance, we have constructed a regulatable
bidirectional adenovector expressing Green Fluorescent Protein and oct4, sox2, klf4 and c-myc genes
(known as the Yamanaka genes or OSKM).

Results:

Partial cell reprogramming has been used to reprogram fibroblasts to cardiomyocytes, neural
progenitors and neural stem cells. Rejuvenation by cyclic partial reprogramming has been achieved
both in vivo and in cell culture using transgenic mice and cells expressing the OSKM genes, respectively,
controlled by a regulatable promoter.

Conclusion:

Partial reprogramming emerges as a powerful tool for the genesis of iPSC-free induced
somatic cells of therapeutic value and for the implementation of in vitro and in vivo rejuvenation keeping
cell type identity unchanged.
Diabetes mellitus and DPP IV/CD26 Inhibitors
Authors: Batičić Lara , Detel Dijana , Varljen Jadranka , Pernjak Pugel Ester , Grčić Antonijo , Ivanović Lara
Published: September 2019

Šećerna bolest ili dijabetes (lat. diabetes mellitus) metabolička je bolest kronične naravi, karakterizirana perzistentnom hiperglikemijom te poremećajima u metabolizmu ugljikohidrata, masti i proteina. Bolest se dijeli na dijabetes tipa 1 i 2, gestacijski dijabetes te ostale, manje zastupljene oblike. Zbog velikog rasta incidencije i prevalencije bolesti, riječ je o značajnom javno-zdravstvenom problemu te jednom od deset vodećih uzroka smrtnosti u svijetu. Dipeptidil-peptidaza IV, odnosno molekula CD26 (DPP IV/CD26, EC 3.4.14.5), ubikvitaran je multifunkcionalan transmembranski i solubilni glikoprotein te serinska peptidaza, prepoznat kao krucijalan čimbenik u održavanju homeostaze glukoze u krvi, prije svega zbog mogućnosti razgradnje inkretina. Znanstvena i klinička ispitivanja ukazala su na visok terapijski potencijal inhibitora enzimske aktivnosti DPP IV/CD26 kod oboljelih od dijabetesa. Ovaj se pregledni rad fokusira na različite aspekte dijabetesa tipa 1 i 2 te novije mogućnosti terapije ovih oboljenja, s posebnim osvrtom na inhibitore DPP IV/CD26 kao efikasne terapijske opcije.
Psorijaza – vidljivi ubojica
Authors: Gašparini Dora , Kaštelan Marija
Published: September 2019

Psorijaza je jedna od najčešćih kroničnih kožnih bolesti s prevalencijom od 1,6 – 3 % u općoj populaciji, stoga je ta bolest vrlo važan javnozdravstveni problem. Riječ je o upalnom imunosno posredovanom poremećaju koji se na koži očituje eritematoskvamoznim plakovima na predilekcijskim mjestima. Psorijaza nije životno ugrožavajuća bolest, ali kardiovaskularni rizični čimbenici povezani s njom mogu dovesti do letalnog ishoda. Metabolički sindrom češće se dijagnosticira u pacijenata sa psorijazom u odnosu na opću populaciju, i to ponajviše u pacijentica starijih od 40 godina koje dugo boluju od teškog oblika bolesti. Etiologija razvoja metaboličkih poremećaja nije još u potpunosti razjašnjena, ali postoje dokazi da metaboličke promjene nisu isključivo posljedica dugotrajno aktivne kožne bolesti, već da i prethode prvoj pojavi bolesti. Imunosni odgovor posredovan T-pomoćničkim (engl. T helper, Th) Th1 i Th17 limfocitima sustavno prisutan u pacijenata sa psorijazom pridonosi razvoju ili pogoršanju šećerne bolesti, arterijske hipertenzije i pretilosti. Terapija psorijaze temelji se na liječenju kožne bolesti i komorbiditeta, a prilagođena je pojedinom pacijentu. Primjena metotreksata i bioloških lijekova poput infliksimaba, adalimumaba i etanercepta povezana je s nižim stopama mortaliteta, infarkta miokarda i moždanog udara te s poboljšanjem endotelne funkcije u odnosu na pacijente liječene drugim terapijskim mogućnostima. Pristup pacijentu sa psorijazom mora biti sveobuhvatan i multidisciplinaran te uključivati liječenje psorijaze uz prevenciju, rano prepoznavanje i odgovarajuće liječenje komorbiditeta.
Procjena uspješnosti protetičke rehabilitacije osoba s amputacijom donjeg uda
Authors: Grubić Kezele Tanja , Mršić Dunja , Radović Endi , Fužinac-Smojver Ariana
Published: September 2019

Cilj: Protetička rehabilitacija nakon amputacije donjeg uda uključuje sve kompleksne postupke i interakcije rehabilitacijskog tima i pacijenta koje su usmjerene cilju uspostavljanja sigurnog i stabilnog hoda s protezom. Nakon otpuštanja iz rehabilitacijskog centra pacijent koristi protezu, sukladno dobi, stilu života i okolini u kojoj živi. Cilj: Cilj rada je procijeniti uspješnost protetičke rehabilitacije osoba s amputacijom donjeg uda koristeći indekse predviđene mobilnosti pacijenta (engl. Amputee Mobility Predictor; AMP) i brzinu hoda. Ispitanici i metode: U radu su korišteni podaci pacijenata iz baze podataka Zavoda za fizikalnu i rehabilitacijsku medicinu Kliničkog bolničkog centra u Rijeci, a pri tome su u skladu s Helsinškom deklaracijom ostali anonimni: dob, spol, vrsta i strana amputacije, AMP, brzina hoda i vrijeme provedeno u protezi. Od sto pacijenata s amputacijom 62 su bila transtibijalna (TT) i 38 transfemoralna (TF). U ispitivanju je sudjelovalo 27 žena i 73 muškarca. Svim pacijentima je utvrđen AMP indeks prije rehabilitacijskog postupka (AMPnoPRO) te nakon završenog rehabilitacijskog postupka (AMPPRO). Rezultati: Nakon provedene protetičke rehabilitacije utvrđena je statistički značajna razlika u konačnoj mobilnosti (AMP: p < 0,001) i brzini hoda (p = 0,002) između TT i TF grupa, odnosno bolji rezultat su postigli pacijenti s nižom razinom amputacije (TT). Također je utvrđena statistički značajna povezanost između vremena provedenog u protezi i brzini hoda te AMP indeksa (p < 0,001). Zaključak: Razina amputacije je važna stavka koja pridonosi konačnom ishodu rehabilitacijskog postupka, odnosno viša razina amputacije kod pacijenata (TF) predstavlja jedan oblik ograničenja za bolji uspjeh u odnosu na pacijente s nižom razinom amputacije (TT).
Izgladnjivanje kao sudskomedicinski problem
Authors: Šoša Ivan , Štefanac Filip , Stemberga Valter
Published: September 2019

Izgladnjivanje do smrti samo je iznimno uzrok smrti u razvijenim zemljama. Međutim, ova pojava može imati daleko veći značaj ako je sudskomedicinski gledano smrt posljedica namjernog uskraćivanja hrane. U takvim slučajevima zadatak specijalista sudske medicine ili patologa je razjasniti uzrok smrti i dati stručno mišljenje o stupnju i trajanju gladi. Za procjenu proteinsko-energijske pothranjenosti razvijeno je nekoliko klasifikacijskih sustava koji se također opisuju u članku. Mnogo je faktora vezanih uz dob koji mogu dovesti do gubitka apetita i smanjenja težine, te se u preglednom članku oni i razmatraju. Sudskomedicinski su posebno interesantni slučajevi izgladnjivanja u kojima su, u sklopu pojave zlostavljanja i zanemarivanja, pogođena djeca,. Upravo takve primjere iz literature i navodimo u radu, uz osvrt na osobe starije životne dobi. Ove su osobe, zbog nerazmjera u odnosu snaga, posebno ugrožena skupina, kod koje je također najčešći tip pothranjenosti proteinsko-energijska pothranjenost.
The Service of Research Analytics to Optimize Digital Health Evidence Generation: Multilevel Case Study
Authors: Pham Quynh , Shaw James , Morita Plinio P , Seto Emily , Stinson Jennifer N , Cafazzo Joseph A
Published: September 2019

Background

The widespread adoption of digital health interventions for chronic disease self-management has catalyzed a paradigm shift in the selection of methodologies used to evidence them. Recently, the application of digital health research analytics has emerged as an efficient approach to evaluate these data-rich interventions. However, there is a growing mismatch between the promising evidence base emerging from analytics mediated trials and the complexity of introducing these novel research methods into evaluative practice.

Objective

This study aimed to generate transferable insights into the process of implementing research analytics to evaluate digital health interventions. We sought to answer the following two research questions: (1) how should the service of research analytics be designed to optimize digital health evidence generation? and (2) what are the challenges and opportunities to scale, spread, and sustain this service in evaluative practice?

Methods

We conducted a qualitative multilevel embedded single case study of implementing research analytics in evaluative practice that comprised a review of the policy and regulatory climate in Ontario (macro level), a field study of introducing a digital health analytics platform into evaluative practice (meso level), and interviews with digital health innovators on their perceptions of analytics and evaluation (microlevel).

Results

The practice of research analytics is an efficient and effective means of supporting digital health evidence generation. The introduction of a research analytics platform to evaluate effective engagement with digital health interventions into a busy research lab was ultimately accepted by research staff, became routinized in their evaluative practice, and optimized their existing mechanisms of log data analysis and interpretation. The capacity for research analytics to optimize digital health evaluations is highest when there is (1) a collaborative working relationship between research client and analytics service provider, (2) a data-driven research agenda, (3) a robust data infrastructure with clear documentation of analytic tags, (4) in-house software development expertise, and (5) a collective tolerance for methodological change.

Conclusions

Scientific methods and practices that can facilitate the agile trials needed to iterate and improve digital health interventions warrant continued implementation. The service of research analytics may help to accelerate the pace of digital health evidence generation and build a data-rich research infrastructure that enables continuous learning and evaluation.
Pengukuran Kualitas Hidup Pasien Program Pengelolaan Penyakit Kronis (Prolanis) di Puskesmas Menggunakan Instrumen EQ-5D-5L
Authors: Hamida Nur , Ulfa Mursyida , Haris Restu Nur Hasanah , Endarti Dwi , Wiedyaningsih Chairun
Published: September 2019

Prevalensi penyakit diabetes melitus (DM) dan hipertensi di Indonesia semakin tahun semakin meningkat. Pemerintah melalui Badan Penyelenggara Jaminan Sosial (BPJS) mencanangkan Program Pengelolaan Penyakit Kronis (Prolanis) untuk mencapai kesehatan yang optimal dan kualitas hidup yang baik pada penyakit DM dan hipertensi. Studi ini bertujuan untuk mengukur kualitas hidup pasien prolanis di puskesmas menggunakan instrumen EQ-5D-5L. Studi dilakukan pada 200 pasien prolanis yang terdiri dari 100 pasien diabetes melitus dan 100 pasien hipertensi. Lokasi pengambilan sampel berada di puskesmas Kota Palu Provinsi Sulawesi Tengah untuk pasien DM dan Kabupaten Aceh Barat Provinsi Nangroe Aceh Darussalam untuk pasien hipertensi yang dilakukan dalam kurun waktu 3 bulan (September-November 2018). Penelitian menggunakan rancangan cross-sectional study dengan metode convenience/accidental sampling. Kualitas hidup diukur menggunakan instrumen European Quality of Life-5 Dimension-5 Level (EQ-5D-5L) dan konversi health utility (utility) dengan value set Indonesia. Analisis data menggunakan uji independent t-test untuk melihat perbedaan kualitas hidup pada tiap kelompok karakteristik  pasien DM dan hipertensi. Hasil penelitian menunjukkan domain rasa sakit/tidak nyaman merupakan domain yang paling banyak dilaporkan terjadi masalah pada pasien DM maupun Hipertensi. Nilai utility pasien DM sebesar 0,843±0,081, sedangkan hipertensi sebesar 0,767±0,154. Terdapat perbedaan signifikan nilai utility berdasarkan karakteristik umur (p=0,001), riwayat penyakit keluarga (p=0,006), lama menderita penyakit (p=0,000) dan frekuensi kontrol (p=0,000) pada pasien hipertensi, sedangkan pada pasien DM hanya pada karakteristik memiliki penyakit lain (p=0,026).
Perspectives for a Social Integration of Human Rights in the Muslim World
Authors: Garlando Efrem
Published: September 2019

Human Rights are defined as sort of humankind “Esperanto”, a neutral language able to promote the difficult task of dialogue across communities. When speaking about “Islam”, it is easy or generates a misunderstanding, because the word Islam does not refers to a monolithic entity: Ummah, the global community of all Muslim believers, is indeed plural and fragmentary from both a geographical and a cultural perspective. In the course of my essay, I will start from the work of John Rawls and Abdullahi Ahmed An- Naim, then focus on a new concept of Human Rights, stressing practical tools rather than hermeneutical ones. As a matter of fact this project should start within the Islamic world in order to be more easily accepted. Furthermore, it is necessary to firstly undertake this task there, so that it cannot be claimed to be the result of western cultural imperialism. The Islamic countries ought to rethink the idea of “public reason”, which must not be confused with the “reason of the sovereign” and should instead outcomes from the dialogue between people. This is possible thanks to a progressive rooting out of the traditional concept of Shari’a and a renovated concept of ijtihad, the concept of personal reasoning, so that the Islamic world can achieve a stronger critical sense towards itself and its religious dogmatism.