bluuebunny/crossref_metadata_2025 huggingface dataset:
Hippocampal volume in cases of relapsing remitting multiple sclerosis and its correlation with cognitive impairment
Authors:   Department of Neurology, Mansoura University, Mansoura, Egypt, Eltoukhy Khaled , Esmael Ahmed ,   Department of Neurology, Mansoura University, Mansoura, Egypt, Abdelkhalek Ahmed M. ,   Department of Neurology, Mansoura University, Mansoura, Egypt, Nagy Asem ,   Department of Neurology, Mansoura University, Mansoura, Egypt
Published: July 2023

Background. Multiple sclerosis (MS) is a chronic inflammatory immune-mediated disease, distinguished by demyelination and oligodendropathy in the central nervous system. Cognitive impairment (CI) can impact patients at any stage of MS, including those with clinically isolated syndrome (CIS). Patients and methods. This is a prospective cross-sectional study which enrolled 60 patients with RRMS. They were subjected to cognitive scale assessment, routine brain MRI study and volumetric assessment of hippocampus. Results. This study found a significant positive correlation between duration of disease and Subjective memory complaints questionnaire (r=0.525, p=0.001). A significant negative correlation existed between disease duration and MMSE score (r=-0.404, p=0.001) and between disease duration and MoCA score (r=-0.310, p=0.016). No significant difference between both groups regarding the relative hippocampal volume. Mean relative right hippocampal volume is 0.0026 for cases versus 0.0027 among control group and mean relative left hippocampal volume is 0.0025 for cases versus 0.0026 among control group. Conclusion. Multiple sclerosis disease duration had an impact on cognitive state. However, hippocampal volume assessment did not predict the cognitive affection in patient with RRMS.
Central Nervous System tumor at “Prof. Dr. I.G.N.G. Ngoerah” General Hospital, Denpasar: An epidemiological study between 2020-2022
Authors:   Department of Anatomical Pathology, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia, Dewi I Gusti Ayu Sri Mahendra ,   “Prof. Dr. I.G.N.G. Ngoerah” General Hospital, Denpasar, Bali, Indonesia, Seputra Desak Made Cittarasmi Saraswati ,   Department of Neurology, Wangaya Regional Hospital, Denpasar, Bali, Indonesia, Sriwidyani Ni Putu ,   Department of Anatomical Pathology, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia,   “Prof. Dr. I.G.N.G. Ngoerah” General Hospital, Denpasar, Bali, Indonesia
Published: July 2023

Background. Central Nervous System (CNS) tumor is neoplasm that located in central nervous system, which include brain and medulla spinalis. Despite its significant raise of incidence and morbidities, limited epidemiological data was available. Therefore, this study aimed to describe the epidemiological characteristic of CNS tumor over a 3-year period in a single tertiary hospital in Bali, Indonesia. Methods. This study was a descriptive study with cross sectional design. This study included all patients aged 18 year or over who were histopathologically diagnosed with central nervous tumor at “Prof. Dr. I.G.N.G. Ngoerah General Hospital”, Denpasar, between January 2020 and December 2022. Data about age, gender, tumor location, histopathological type, tumor grading, and source of metastases in secondary CNS tumor were obtained from medical record. Result. A total of 221 cases were recorded during this study period. The prevalence of primary CNS tumor was 81.9% while secondary CNS tumor was 18.1%. The majority of case, both in primary and secondary CNS tumor were female in age group of 50-59. Supratentorial constituted the most common lesion site in primary and secondary CNS tumor. The most frequent histopathological type of primary CNS tumor was meningioma, making up 48.1% of cases, followed by diffuse astrocytic and oligodendroglial tumors (26.5%), and tumor of the cranial and paraspinal nerve (9.9%). Carcinoma is the most common histological type in secondary CNS tumor with lung and breast tumor being the majority source of secondary CNS tumor, found in 40% and 27.5%, respectively. Conclusion. Adult female with age of 50-59 is the most affected group in CNS tumor. Primary CNS tumor were commonly found in supratentorial with meningioma and WHO grade I being the most frequent histopathological type and grade. Secondary CNS tumor were mostly found in supratentorial and originated from primary lung tumor.
TÜRKİYE’DE NÜFUSUN YAŞLANMASI ÜZERİNE BİR SWOT ANALİZİ
Authors: KESKİN Muhammet , KOÇAK Hüseyin
Published: July 2023

Dünya, 21 yüzyılda demografik değişimlerin somut olarak yaşandığı bir döneme tanıklık etmektedir. Demografik değişim sürecinde nüfusun yaş yapısı değişmektedir. Doğum ve ölüm oranlarının azalması, ortalama yaşam süresinin uzaması ve göç hareketliliği nüfusun yaşlanmasına neden olan en temel unsurlardandır. Bu çalışmanın amacı Türkiye’de nüfusun yaşlanma sürecinde etkili olan ana faktörleri incelemek ve nüfusun yaşlanma sürecinde ortaya çıkan güçlü ve zayıf yönler ile fırsat ve tehditleri SWOT analizi aracılığıyla belirlemektir. Çalışmanın yöntemi için öncelikle nüfusun yaşlanmasına yönelik literatürde yapılan çalışmalar belli bir sistematik çerçevede incelenmiş ve SWOT analizi için gerekli boyutlara ilgili çalışmalardan ulaşılmıştır. Sonrasında nüfusun yaşlanmasında etkili olan temel faktörlere ilişkin istatistiki bilgiler ikincil veri kaynaklarından toplanmış ve durum tespiti yapılmıştır. Sağlık koşullarının iyileşmesi, teknolojik ve bilimsel gelişmeler sonucunda ortalama yaşam süresi uzamış ve nüfusun yaşlanma süreci başlamıştır. Türkiye’de ise nüfusun yaşlanma süresi çok hızlı bir şekilde gerçekleşmektedir.
The Unexpected Optical and Ultraviolet Variability of the Standard Star α Sex (HD 87887)
Authors: Monier Richard , Bowman Dominic M. , Lebreton Yveline , Deal Morgan
Published: July 2023

The analysis of the available Transiting Exoplanet Survey Satellite (TESS) light curves of α Sex (HD 87887) reveals low-frequency pulsations with a period of about 9.1 hr in this spectroscopic A0 III standard star. The IUE observations in 1992 December reveal large flux variations both in the far-UV and in the mid-UV, which are accompanied by variations of the brightness in the V band recorded by the the Fine Error Sensor on board IUE. The ultraviolet variability could be due to an eclipse by an hitherto undetected companion of smaller radius, possibly 2.5 R
⊙, but this needs confirmation by further monitoring possibly with TESS. An abundance determination yields solar abundances for most elements. Only carbon and strontium are underabundant and titanium, vanadium, and baryum mildly overabundant. Identification is provided for most of the lines absorbing more than 2% in the optical spectrum of α Sex. Stellar evolution modeling shows that α Sex is near the terminal-age main sequence, and its mass, radius, and age are estimated to be M = 2.57 ± 0.32 M
⊙, R = 3.07 ± 0.90 R
⊙, A = 385 ± 77 Myr, respectively.
Long-duration Gamma-Ray Burst Progenitors and Magnetar Formation
Authors: Song Cui-Ying , Liu Tong
Published: July 2023

Millisecond magnetars produced in the center of dying massive stars are one prominent model to power gamma-ray bursts (GRBs). However, their detailed nature remains a mystery. To explore the effects of the initial mass, rotation rate, wind mass loss, and metallicity on the GRB progenitors and the newborn magnetar properties, we evolve 227 of 10–30 M
⊙ single star models from the pre-main sequence to core collapse by using the stellar evolution code MESA. The presupernova properties, the compactness parameter, and the magnetar characteristics of models with different initial parameters are presented. The compactness parameter remains a nonmonotonic function of the initial mass and initial rotation rate when the effects of varying metallicity and the “Dutch” wind scale factor are taken into account. We find that the initial rotation rate and mass play the dominant roles in whether a star can evolve into a GRB progenitor. The minimum rotation rate necessary to generate a magnetar gradually reduces as the initial mass increases. The greater the initial metallicity and “Dutch” wind scale factor, the larger the minimum rotation rate required to produce a magnetar. In other words, massive stars with low metallicity are more likely to harbor magnetars. Furthermore, we present the estimated period, magnetic field strength, and masses of magnetars in all cases. The typical rotational energy of these millisecond magnetars is sufficient to power long-duration GRBs.
Energy Repartition and Entropy Generation across the Earth’s Bow Shock: MMS Observations
Authors: Agapitov O. V. , Krasnoselskikh V. , Balikhin M. , Bonnell J. W. , Mozer F. S. , Avanov L.
Published: July 2023

The evolution of plasma entropy and the process of plasma energy redistribution at the collisionless plasma shock front are evaluated based on the high temporal resolution data from the four Magnetospheric Multiscale spacecraft during the crossing of the terrestrial bow shock. The ion distribution function has been separated into the populations with different characteristic behaviors in the vicinity of the shock: the upstream core population, the reflected ions, the gyrating ions, the ions trapped in the vicinity of the shock, and the downstream core population. The values of ion and electron moments (density, bulk velocity, and temperature) have been determined separately for these populations. It is shown that the solar wind core population bulk velocity slows down mainly in the ramp with the electrostatic potential increase but not in the foot region as it was supposed. The reflected ion population determines the foot region properties, so the proton temperature peak in the foot region is an effect of the relative motion of the different ion populations, rather than an actual increase in the thermal speed of any of the ion population. The ion entropy evaluated showed a significant increase across the shock: the enhancement of the ion entropy occurs in the foot of the shock front and at the ramp, where the reflected ions are emerging in addition to the upstream solar wind ions, the anisotropy growing to generate the bursts of ion-scale electrostatic waves. The entropy of electrons across the shock does not show a significant change: electron heating goes almost adiabatically.
Green Bank Telescope Discovery of the Redback Binary Millisecond Pulsar PSR J0212+5321
Authors: Perez Karen I. , Bogdanov Slavko , Halpern Jules P. , Gajjar Vishal
Published: July 2023

We report the discovery of a 2.11 ms binary millisecond pulsar during a targeted search of the redback optical candidate coincident with the γ-ray source 3FGL J0212.5+5320 using the Robert C. Byrd Green Bank Telescope (GBT) with the Breakthrough Listen backend at L band. Over a seven month period, five pointings were made near inferior conjunction of the pulsar in its 20.9 hr orbit, resulting in two detections, lasting 12 and 42 minutes. The pulsar dispersion measure (DM) of 25.7 pc cm−3 corresponds to a distance of 1.15 kpc in the NE2001 Galactic electron density model, consistent with the Gaia parallax distance of 1.16 ± 0.03 kpc for the companion star. We suspect the pulsar experiences wide orbital eclipses, similar to other redbacks, as well as scintillation and DM delays caused by its interaction with its companion and surroundings. Although the pulsar was only detected over ≈3.7% of the orbit, its measured acceleration is consistent with published binary parameters from optical radial velocity spectroscopy and light-curve modeling of the companion star, and it provides a more precise mass ratio and a projected semimajor axis for the pulsar orbit. We also obtained a refined optical photometric orbit ephemeris, and observed variability of the tidally distorted companion over 7 yr. A hard X-ray light curve from NuSTAR shows expected orbit-modulated emission from the intrabinary shock. The pulsar parameters and photometric ephemeris greatly restrict the parameter space required to search for a coherent timing solution including pulsar spin-down rate, either using Fermi γ-rays or further radio pulse detections.
Stellar Collisions in Galactic Nuclei: Impact on Destructive Events Near a Supermassive Black Hole
Authors: Balberg Shmuel , Yassur Gilad
Published: July 2023

The centers of galaxies host both a supermassive black hole and a dense stellar cluster. Such an environment should lead to stellar collisions, possibly at very high velocities so that the total energy involved is of the same order as supernova explosions. We present a simplified numerical analysis of the destructive stellar collision rate in a cluster similar to that of the Milky Way. The analysis includes an effective average two-body relaxation Monte Carlo scheme and general relativistic effects, as used by Sari & Fargione, to which we added explicit tracking of local probabilities for stellar collisions. We also consider stars which are injected into the stellar cluster after being disrupted from a binary system by the supermassive black hole. Such stars are captured in the vicinity of the black hole and enhance the expected collision rate. In our results we examine the rate and energetic distribution function of high-velocity stellar collisions, and compare them self-consistently with the other destructive processes which occur in the galactic center, namely tidal disruptions and extreme mass ratio inspirals.
Core States of Neutron Stars from Anatomizing Their Scaled Structure Equations
Authors: Cai Bao-Jun , Li Bao-An , Zhang Zhen
Published: July 2023

Given an Equation of State (EOS) for neutron star (NS) matter, there is a unique mass–radius sequence characterized by a maximum mass

M

NS

max

at radius R
max. We first show analytically that the

M

NS

max

and R
max scale linearly with two different combinations of the NS central pressure P
c and energy density ε
c, by dissecting perturbatively the dimensionless Tolman–Oppenheimer–Volkoff (TOV) equations governing NS internal variables. The scaling relations are then verified via 87 widely used and rather diverse phenomenological as well as 17 microscopic NS EOSs with/without considering hadron–quark phase transitions and hyperons, by solving numerically the original TOV equations. The EOS of the densest NS matter allowed before it collapses into a black hole is then obtained. Using the universal

M

NS

max

and R
max scalings and Neutron Star Interior Composition Explorer and XMM-Newton mass–radius observational data for PSR J0740+6620, a very narrow constraining band on the NS central EOS is extracted directly from the data for the first time, without using any specific input EOS model.
Development of an Empirical Model of the Force between Paramagnetic Particles in Uniform Magnetic Field on M-type Asteroids
Authors: Sikka Anmol , DesJardin Ian , Leps Thomas , Hartzell Christine
Published: July 2023

M-type asteroids may have remanent magnetic fields. Regolith particles on M-type asteroids are likely to have metallic components, causing them to be paramagnetic and respond to an external magnetic field. Paramagnetic particles placed in an external magnetic field are influenced by induced magnetic moments of neighboring particles. Therefore, the magnetic force between regolith particles on an M-type asteroid can change the net cohesion of the regolith. Previous works have shown the influence of cohesive forces in the evolution of rubble-pile asteroids. This work characterizes the magnetic force between regolith particles on M-type asteroids. We implement existing models of the magnetic force between paramagnetic particles placed in an external magnetic field and then present an empirical model of this force for two magnetic field orientations as an essential step toward a general semiempirical model that the wider planetary science community can more easily use to investigate the significance of this force.
Stingless bee classification and biology (Hymenoptera, Apidae): a review, with an updated key to genera and subgenera
Authors: Engel Michael S. , Rasmussen Claus , Ayala Ricardo , de Oliveira Favízia F.
Published: July 2023

Stingless bees (Meliponini) are a ubiquitous and diverse element of the pantropical melittofauna, and have significant cultural and economic importance. This review outlines their diversity, and provides identification keys based on external morphology, brief accounts for each of the recognized genera, and an updated checklist of all living and fossil species. In total there are currently 605 described extant species in 45 extant genera, and a further 18 extinct species in nine genera, seven of which are extinct. A new fossil genus, Adactylurina Engel, gen. nov., is also described for a species in Miocene amber from Ethiopia. In addition to the systematic review, the biology of stingless bees is summarized with an emphasis on aspects related to their nesting biology and architecture.
Further representations and computations of the generalized Moore-Penrose inverse
Authors: Zuo Kezheng , Chen Yang , Yuan Li
Published: July 2023

The aim of this paper is to provide new representations and computations of the generalized Moore-Penrose inverse. Based on the Moore-Penrose inverse, group inverse, Bott-Duffin inverse and certain projections, some representations for the generalized Moore-Penrose inverse are given. An equivalent condition for the continuity of the generalized Moore-Penrose inverse is proposed. Splitting methods and successive matrix squaring algorithm for computing the generalized Moore-Penrose inverse are presented.
Generalizations of some $ q $-integral inequalities of Hölder, Ostrowski and Grüss type
Authors: Shi Da , Farid Ghulam , Elamin Abd Elmotaleb A. M. A. , Akram Wajida , Alahmari Abdullah A. , Younis B. A.
Published: July 2023

This paper investigates some well-known inequalities for $ q $-$ h $-integrals. These include Hölder, Ostrowski, Grüss and Opial type inequalities. Refinement of the Hadamard inequality for $ q $-$ h $-integrals is also established by applying the definition of strongly convex functions. From main theorems, $ q $-Hölder, $ q $-Ostrowski and $ q $-Grüss inequalities can be obtained in particular cases.
Investigation of a nutrient-plankton model with stochastic fluctuation and impulsive control
Authors: Zhao Xin , Wang Lijun , Tiwari Pankaj Kumar , Liu He , Wang Yi , Li Jianbing , Zhao Min , Dai Chuanjun , Guo Qing
Published: July 2023

In this paper, we investigate a stochastic nutrient-plankton model with impulsive control of the nutrient concentration and zooplankton population. Analytically, we find that the population size is nonnegative for a sufficiently long time. We derive some sufficient conditions for the existence of stable periodic oscillations, which indicate that the plankton populations will behave periodically. The numerical results show that the plankton system experiences a transition from extinction to the coexistence of species due to the emergence of impulsive control. Additionally, we observe that the nutrient pulse has a stronger relationship with phytoplankton growth than the zooplankton pulse. Although the frequency of impulsive control and appropriate environmental fluctuations can promote the coexistence of plankton populations, an excessive intensity of noise can result in the collapse of the entire ecosystem. Our findings may provide some insights into the relationships among nutrients, phytoplankton and zooplankton in a stochastic environment.
Un caso singular de prólogo metalexicográfico. El Diccionario Popular Universal de la Lengua Española de Luis P. de Ramón (1885-1889)
Authors: Marimón Llorca Carmen
Published: July 2023

El objetivo de este trabajo es analizar el “Prólogo” del Diccionario Popular Universal de la Lengua Española, (Barcelona, 1885-1889), recopilado y dirigido por Luis P. de Ramón. Se trata de un ejemplo excepcional entre los de la época por su extensión—25 páginas—, sus fuentes —es deudor directo, entre otros, de la “Préface” del GDU de Pierre Larousse—, pero, sobre todo, por su singularidad metalexicográfica al ser el primero que realiza un recorrido crítico de la lexicografía española y extranjera. Se realiza un estudio minucioso de fuentes, intertextualidad, influencias y propósitos con el fin de aportar nuevos datos para el estudio de la lexicografía no académica del siglo XIX.
La abrumadora conciencia de lo real: tres reescrituras dramáticas áureas de La fuerza de la sangre
Authors: Martín González Pablo
Published: July 2023

La fuerza de la sangre de Miguel de Cervantes contó con tres reescrituras dramáticas a lo largo del siglo XVII: la homónima de Guillén de Castro (1625), El agravio satisfecho (1629) de Alonso de Castillo Solórzano, y No hay cosa como callar (1662) de Pedro Calderón de la Barca. Este trabajo propone un análisis estructural de la novela cervantina que nos permita determinar sus elementos constructivos y su relación con diversas configuraciones genológicas. En segundo lugar, revisaremos las modificaciones estructurales que las tres reescrituras operan sobre el esquema narrativo de Cervantes.
Disability and Aerial Arts
Authors: Ball Erin
Published: July 2023

This writing accompanies the documentary video of a workshop that Erin Ball helped to facilitate in July 2022 for the Disability community (including but not limited to Mad, Deaf, Neurodivergent, and/or Disabled). In this text, Erin Ball, a circus artist who is a double below-knee amputee, discusses embodied personal knowledge as a practitioner and workshop leader in the emerging area of aerial arts that strives for inclusion. Erin describes the philosophical and pedagogical approaches taken to making the aerial workshops more accessible to communities often excluded from circus arts.Ce texte accompagne le documentaire vidéo sur un atelier co-animé par Erin Ball en juillet 2022 à l’intention de la communauté des personnes handicapées (et plus particulièrement des personnes sourdes, neurodivergentes, atteintes de pathologies mentales et/ou handicapées). Dans ce texte, Erin Ball, une artiste de cirque qui est aussi amputée des deux jambes sous le genou, analyse le rôle de la cognition incarnée en tant que praticienne et animatrice d’ateliers dans un domaine émergent – les disciplines aériennes – qui recherche une plus grande inclusivité. Erin décrit les approches philosophiques et pédagogiques qui tendent à rendre les ateliers aériens plus accessibles aux communautés le plus souvent exclues des arts du cirque.
Participation, Collective Impact, and Your Instrumental Significance
Authors: Nefsky Julia
Published: July 2023

There are many sorts of day-to-day choices that are such that, if enough people were to choose one way rather than another, serious harm could be avoided or reduced, and yet it does not seem that any one such choice will itself make a difference. Consider, for example, how our collective consumer choices have various serious environmental and social consequences, and yet for many products, it is doubtful that one purchase more or less will itself make a difference to these outcomes. How are we to understand what each of us ought to do in these sorts of contexts? This paper further advances and illuminates a thesis that I have argued for elsewhere: that a purely ‘non-instrumental’ approach to this question is not satisfactory. A necessary and central part of understanding how to think about an individual choice in these contexts is showing that it does matter for instrumental reasons - for reasons having to do with its ability to have an influence on the outcome. Once a core instrumental solution is found, other moral considerations can build on top. I argue for this by way of an examination of a new non-instrumental approach advanced by Wieland and van Oeveren: a participation-based approach. I also identify what I think is the main source of resistance to my thesis: a mistaken conflation of two different problems.
Mixed Spin Ising Ferrimagnetic System in the Oguchi Approximation
Authors: Hemzah Yaseen Merzah , Khrajan Mousa M. , Mohamad Hadey K.
Published: July 2023

It has been investigated an Ising ferrimagnet with mixed spin-2 and spin-5/2 and various crystal field parameters on a body-centered cubic lattice. In this research paper, ferrimagnetic compensation temperatures and phase transitions to clarify the characteristic features, in a series of molecular-based magnets AFeIIFeIII(C2O4)3[A=N(n-CnH2n+1)4, n=3-5] are examined in the Oguchi approximation (OA). The spin crystal domain dependence of compensation behavior acting on ions contain the Oguchi lattice, is mainly studied. It is discovered, specifically, that magnetic anisotropies in the disordered for the two sublattices of the model depend on the negative values of the crystal fields to produce a characteristic ferrimagnetic behavior. For DA/|J|=-1.5 and DB/|J|=-5.5, there are two compensation points are induced at an ordered phase(2,-1.5).
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2
Authors: Yu Hong , Worrall Liam J , Berger Thorsten , Petric Martin , Lin Bryan H , Vuckovic Marija , Robb Craig S , Le Quan , Kenward Calem , Dai Chuanbin , Wakeham Andrew , Liu Shaofeng , Snow Bryan , Tobin Chantal , Budylowski Patrick , Guvenc Furkan , You-Ten Annick , Haight Jillian , Silvester Jennifer , Singh Rashim Pal , Ahn Sang Kyun , Sultana Azmiri , Poon Betty , Lam Jessica , Christie-Holmes Natasha , Ostrowski Mario , Gray-Owen Scott D , Kubli Shawn , Mak Tak , Strynadka Natalie C J , Brunham Robert C
Published: July 2023

Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as mRNA, viral vector, or protein subunit. However, the SARS-CoV-2 receptor-binding domain (RBD) is the immunodominant portion of the spike protein, accounting for 90% of serum neutralizing activity. In this study, we constructed several versions of RBD and together with aluminum hydroxide or DDA (dimethyldioctadecylammonium bromide)/TDB (d-(+)-trehalose 6,6′-dibehenate) adjuvant evaluated immunogenicity in mice. We generated human angiotensin-converting enzyme 2 knock-in mice to evaluate vaccine efficacy in vivo following viral challenge. We found that 1) subdomain (SD)1 was essential for the RBD to elicit maximal immunogenicity; 2) RBDSD1 produced in mammalian HEK cells elicited better immunogenicity than did protein produced in insect or yeast cells; 3) RBDSD1 combined with the CD4 Th1 adjuvant DDA/TDB produced higher neutralizing Ab responses and stronger CD4 T cell responses than did aluminum hydroxide; 4) addition of monomeric human Fc receptor to RBDSD1 (RBDSD1Fc) significantly enhanced immunogenicity and neutralizing Ab titers; 5) the Beta version of RBDSD1Fc provided a broad range of cross-neutralization to multiple antigenic variants of concern, including Omicron; and 6) the Beta version of RBDSD1Fc with DDA/TDB provided complete protection against virus challenge in the knock-in mouse model. Thus, we have identified an optimized RBD-based subunit vaccine suitable for clinical trials.
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis
Authors: He Guangbao , He Yibo , Ni Hongwei , Wang Kai , Zhu Yijun , Bao Yang
Published: July 2023

It has been shown that dexmedetomidine (Dex) could attenuate postoperative cognitive dysfunction (POCD) via targeting circular RNAs (circRNAs). Circ-Shank3 has been found to be involved in the neuroprotective effects of Dex against POCD. However, the role of circ-Shank3 in POCD remains largely unknown. Reverse transcription quantitative PCR (RT-qPCR) was performed to detect circ-Shank3 and miR-140-3p levels in lipopolysaccharide (LPS)-treated microglia BV-2 cells in the absence or presence of Dex. The relationship among circ-Shank3, miR-140-3p and TLR4 was confirmed by dual-luciferase reporter assay. Additionally, Western blot and immunofluorescence (IF) assays were conducted to evaluate TLR4, p65 and Iba-1 or CD11b levels in cells. In this study, we found that Dex notably decreased circ-Shank3 and TLR4 levels and elevated miR-140-3p level in LPS-treated BV2 cells. Mechanistically, circ-Shank3 harbor miR-140-3p, functioning as a miRNA sponge, and then miR-140-3p targeted the 3’-UTR of TLR4. Additionally, Dex treatment significantly reduced TLR4 level and phosphorylation of p65, and decreased the expressions of microglia markers Iba-1 and CD11b in LPS-treated BV2 cells. As expected, silenced circ-Shank3 further reduced TLR4, p65 and Iba-1 and CD11b levels in LPS-treated BV2 cells in the presence of Dex, whereas these phenomena were reversed by miR-140-3p inhibitor. Collectively, our results found that Dex could attenuate the neuroinflammation and microglia activation in BV2 cells exposed to LPS via targeting circ-Shank3/miR-140-3p/TLR4 axis. Our results might shed a new light on the mechanism of Dex for the treatment of POCD.
How to Revise and Resubmit the Manuscript after a Favorable Peer Review?
Authors: Mohta Anup
Published: July 2023

Authors look forward to acceptance of their manuscripts submitted to any journal. It is important that the authors respond to the observations and suggestions made by the reviewers of the manuscript and the editors of the journal. Corresponding author should submit considered point-wise response to each of the queries raised in a polite manner after discussion with all authors within the time-frame provided. Additional literature, analysis and material may be required to respond to the reviewers’ comments. A well crafted complete response is likely to increase the possibilities of acceptance of the manuscript.
Arbeitsgemeinschaft: Higher Rank Teichmüller Theory
Authors: Kassel Fanny , Pozzetti Maria Beatrice , Sambarino Andrés , Wienhard Anna
Published: July 2023

Higher rank Teichmüuller theory is the study of certain connected components of character varieties of surface groups in higher rank semisimple Lie groups, with the property that all elements in these components correspond to faithful representations with discrete image. Like classical Teichmüller theory, this relatively recent theory is very rich and builds on a combination of methods from various areas of mathematics. Its many facets were explored in detail during the Arbeitsgemeinschaft.
Analytic Number Theory
Authors: Matomäki Kaisa , Soundararajan Kannan , Vaughan Robert C. , Wooley Trevor D.
Published: July 2023

Analytic number theory is a subject central to modern mathematics. There are many important unsolved problems which have stimulated a large amount of activity by many talented researchers. At least two of the Millennium Problems can be considered to be in this area. Moreover in recent years there has been very substantial progress on a number of these questions.
Mathematical Advances in Geophysical Fluid Dynamics
Authors: Giga Yoshikazu , Hieber Matthias , Korn Peter , Titi Edriss S.
Published: July 2023

The workshop “Mathematical Advances in Geophysical Fluid Dynamics” addressed recent advances in modeling, analytical, computational and stochastical studies of geophysical flows. Of particular interest were contributions concerning modeling and analysis of sea ice models, well-posedness results for the primitive equations and boundary layers, stratified flows and models for moist atmospheric dynamics including phase transitions.
Enumerative Combinatorics
Authors: Bousquet-Mélou Mireille , Chapuy Guillaume , Drmota Michael , Elizalde Sergi
Published: July 2023

Enumerative Combinatorics focuses on the exact and asymptotic counting of combinatorial objects. It has fruitful connections to several disciplines, including statistical physics, algebraic combinatorics, probability theory, graph theory and computer science. This workshop brought together experts from all these various fields with the goal of promoting cooperation and interaction among researchers with largely varying backgrounds. It was the third workshop on this topic (the first two editions dating back to 2014 and 2018) and this time the main focus was on interactions with algebraic combinatorics.
First Knowledge on Data Poor Stock: LWR and Condition Factor of a Recently Established Population of Atherina boyeri in Atikhisar Reservoir, Turkiye
Authors: Kale Semih , Berber Selcuk , Acarli Deniz , Gurkan Sule
Published: July 2023

Fisheries management practices require reliable data for the assessment of data poor stocks. This paper reported the first knowledge on length-weight relationship (LWR) and condition factor of Atherina boyeri in Atikhisar Reservoir, Çanakkale, Türkiye. A total of 1103 individuals of which 132 were immature was captured in June 2021. The sex ratio male to female was 1:1.75. The relationship between weight (W) and total length (TL), standard length (SL), and fork length (FL) were estimated as W=9E-06TL2.9212, W=1E-05SL2.9082, and W=9E-06FL2.9495. A. boyeri exhibited a negative allometric growth. The mean of Fulton`s condition factor of A. boyeri population in Atikhisar Reservoir was determined as 0.619±0.061. The mean Fulton`s condition factor for female individuals were higher than the males` condition factor and the difference between sexes was statistically significant. The present study made available valuable information on the data poor stock by providing LWR and condition factor of A. boyeri in Atikhisar Reservoir, a new freshwater system for the very euryhaline amphidromous species. The findings of the present study will substantially contribute to the knowledge of the population dynamics of the commercially important species for fisheries managers and decision-makers to maintain sustainable population levels.
Microplastic Pollution at Different Trophic Levels of Freshwater Fish in a Variety of Türkiye`s Lakes and Dams
Authors: Boyukalan Sercan , Yerli Sedat Vahdet
Published: July 2023

Information on the occurrence of microplastic (MP; particles smaller than 5 mm) in freshwater fish biota in the Türkiye is limited. In this study, the microplastic contaminations of seven fish species (Cyprinus carpio, Carassius gibelio, Alburnus spp., Scardinius erythrophthalmus, Vimba vimba, Neogobius fluviatilis, and Perca fluviatilis) collected from Lake Manyas, Lake Uluabat, Lake Gala, Lake Gökgöl, Alaçatı Dam, Beydağ Dam, Tahtalı Dam, and Karaidemir Dam were examined. A total of 610 MP particles were extracted from the gastrointestinal systems of all fish species (n: 406). The ingested MPs were only fibers with the dominant plastic color being blue. The length of microplastics ranged from 0.10 to 4.85 mm. Mean MP length size in C. carpio species 1.40±0.90 mm, in C. gibelio species 1.32±0.88 mm, in Alburnus spp. 1.23±0.90 mm, in S. erythrophthalmus species 0.94±0.79 mm, in V. vimba species 1.11±0.69 mm, in P. fluviatilis species 1.34±0.89 mm, in N. fluviatilis species 1.25±0.97 mm.
Among the studied species, the most fiber microplastic was found in P. fluviatilis. According to habitat and feeding features the highest number of microplastics was found in benthopelagic and invertivore fish. This data is anticipated to form the basis for new research and decision-making processes.
Непрерывные выборки из многозначных отображений и аппроксимация в несимметричных и полулинейных пространствах
Authors: Tsar'kov Igor' Germanovich
Published: July 2023

Обобщается теорема Майкла о непрерывной выборке из многозначных необязательно выпуклозначных отображений. Рассматриваются классические задачи аппроксимации на конус-пространствах для симметричных и несимметричных полунорм. В частности, изучаются условия, гарантирующие существование непрерывной выборки для выпуклых множеств в несимметричных пространствах. На полулинейном пространстве ограниченных выпуклых множеств с полуметрикой Хаусдорфа решается задача о чебышeвском центре для ограниченных семейств этих множеств.
Библиография: 24 наименования.
Development of an Embedded Weighing System for Semi-Trailers Based on Hall Effect Sensor
Authors: Parigot Augusto , Weschenfelder Arthur , Seibert Artur , Lampert Luis Pedro , Veras Rafael , Zanolli Willians
Published: July 2023

The measurement of the cargo weight on semi-trailer trucks is required to several stakeholders in the logistics market, for this information can reduce expenses on vehicle maintenance, risk for load traffic fines and ensures safer driving of the vehicle. The state-of-the-art on on-board weighing systems of semi-trailers with leaf spring suspension adopt several techniques to estimate the load: solutions based on load cells, vibrating-wires force transducers or strain gauges on the chassis, on the suspension springs or on the axles of the vehicle. In this work, a new system based on hall effect sensor was developed and tested for measurement of the axle load in semi-trailers through the linear movement that occurs between the trailer axle and its chassis. This solution has low sensitivity to environmental phenomena not caused by human intervention, such as humidity or temperature variations. A lab test was made to compare some arrangements of magnets and hall effect sensors to find out which interaction provides the best linear response for the displacement range. Next, a mechanical prototype and an embedded hardware were designed and assembled into a tank semi-trailer to test the system at the facilities of Librelato Semi-trailers factory. The test routine consisted of several known water loads in the tank of the semi-trailer, which would repeatedly position its axles over a certified weighbridge. A data acquisition software was developed to capture measure points during loading and unloading processes. When comparing to the weighbridge, the system response presented variations that goes from 15%, with an empty tank, to 2% error, with a fully load tank. The proposed system accomplished good results within the tests conditions and the traffic legislation and presents a competitive development cost, indicating that a further development could be done in order to reach the market.
Study and Development of Photovoltaic Power Generation System for
Hybrid Refrigeration Units Applied in Refrigerated Semi-Trailers
Authors: Pastre Guilherme Garbossa , Boaretto Joel , Zottis Jonatas Lemuel Bispo , Molon Maicon , Conrado Paulo Henrique , Galafassi Daniel , Corso Leandro Luís
Published: July 2023

This article presents the development of a solution that uses solar energy to
power refrigerated semi-trailers. The solution employs photovoltaic cells on the
surfaces of the semi-trailer, combined with a battery pack, which take advantage
of a significant area with solar exposure and generate sufficient electric power
to supply the refrigeration unit responsible for controlling the temperature
inside the climate-controlled chamber. In addition to providing energy for the
refrigeration unit, the solar system can be integrated with the auxiliary
traction system used in some semi-trailers, functioning as a range extender for
the battery. To achieve the main objectives of this development, studies were
conducted to evaluate solar radiation through simulations considering different
regions of Brazil. A hardware system was also developed for energy management
and to drive the refrigeration unit, combining a high-power drive system
composed of filters, DC/DC converters, and transformers to match the voltage
levels of the systems, with a microprocessed circuit for functional logic
control. As a result, a system capable of operating the refrigeration unit using
solar energy was obtained, which can reduce diesel consumption by up to 1800
liters per year.
Application of Linear Electromagnetic Actuators in Vehicular
Suspensions
Authors: Eckert Paulo Roberto , Boff Ben Hur Bandeira , Follmann Lucas , da Silva Oliveira Eduardo , Filho Aly Ferreira Flores , Flores Jeferson Vieira , Perondi Eduardo Andre , Lenz Augusto Schmidt , Poli Mariana Damm , Marcolin Vinicius Campagnaro , Struck Rodrigo
Published: July 2023

This study comprehensively describes the application of linear electromagnetic
actuators in automotive suspension systems, focusing on the electromagnetic
force necessary in suspension systems operating in passive, semi-active, and
active modes and their capability for energy regeneration. The use of
electromagnetic actuators as an alternative to traditional shock absorbers makes
easy the energy harvesting that is typically lost during vertical vehicle
displacement. An initial sizing technique for dimensioning electromagnetic
actuators is applied to estimate the requirements for heavy vehicles.
Experimental tests are conducted to validate the proposed method and assess the
performance of the electromagnetic actuator in the suspension system for
passive, semi-active, and active operations. A suitable extrapolation of the
validated data is performed to determine the feasibility of the application of
the proposed solution for heavy vehicles and identify potential applications and
markets based on the road conditions of the ISO 8608 standard. This study offers
a comprehensive approach to determining the actuator force for the suspension
system and/or studying its potential for energy regeneration. As a result, it
becomes possible to analyze the viability of the actuator replacement and
provides important insights for further research and development.
SỬ DỤNG QUY TRÌNH FENTON HÒA TAN BỤI ĐỒNG THAU: NGHIÊN CỨU ĐỘNG HỌC QUÁ TRÌNH HÒA TAN ĐỒNG
Authors: NGUYỄN VĂN PHƯƠNG  , NGUYỄN XUÂN TÒNG
Published: July 2023

Bụi thải từ các cơ sở gia công đánh bóng đồng thau có hàm lượng đồng cao, có giá trị kinh tế cần phải thu hồi. Hòa tan đồng từ bụi thải trong gia công đồng thau dựa trên phản ứng Fenton là một giải pháp thủy luyện rất đáng quan tâm vì lợi ích kinh tế và môi trường. Phương pháp thiết kế thí nghiệm được sử dụng để xác định các thông số phù hợp bao gồm pH, hàm lượng Fe2+, tốc độ khuấy và hàm lượng H2O2 cho quá trình hòa tan đồng từ bụi đồng thau. Các mô hình động học và các các thông số động học cũng đã được xác định. Kết quả cho thấy hiệu suất hòa tan đồng đạt 97%, cùng với các hằng số vận tốc hòa tan lớn nhất trong quá trình phản ứng xảy ra tại pH 1, [Fe2+] 0,1M, tốc độ khuấy 60 vòng/phút, hàm lượng H2O2 1,8% với lưu lượng 1 mL/phút, trong 2 giờ khảo sát. Dữ liệu động học đã cho thấy có thể sử dụng mô hình động học bậc 1 để giải thích động học quá trình hòa tan đồng từ bụi đồng thau và cơ chế của quá trình được kiểm sáo theo cơ chế phản ứng hóa học bề mặt. Kết quả nghiên cứu đã cho thấy quá trình Fenton có thể sử dụng để hòa tan đồng từ bụi đồng thau làm cơ sở cho các nghiên cứu tiếp theo như điện phân thu hồi đồng kim loại hay sản xuất hóa chất.
TỔNG HỢP VẬT LIỆU TiO2/Fe3O4 NANOCOMPOSIT ĐỂ TÁCH CHIẾT VÀ LÀM GIÀU Pb, ỨNG DỤNG PHÂN TÍCH Pb TRONG MẪU NƯỚC
Authors: TRẦN THỊ THANH THÚY  , VŨ HỮU TÀI  , NGUYỄN VĂN TRỌNG  , LÊ HOÀI ÂN
Published: July 2023

Ion chì trong mẫu được làm giàu bằng vật liệu TiO2/Fe3O4 nanocomposit – chất hấp phụ pha rắn với kỹ thuật chiết pha rắn, sau đó được giải hấp phụ và xác định bằng phương pháp phổ nguyên tử. Tính chất của vật liệu TiO2/Fe3O4 nanocomposit được phân tích bằng các phương pháp SEM, EDX, XRD. Các điều kiện chiết pha rắn sử dụng vật liệu TiO2/Fe3O4 nanocomposit như pH của dung dịch, khối lượng của vật liệu, thời gian hấp phụ, nồng độ chất giải hấp phụ được lần lượt khảo sát để đạt hiệu suất hấp phụ và giải hấp phụ cao nhất. Kết quả cho thấy khi sử dụng 150 mg chất hấp phụ trong 60 phút ở pH 8 và nồng độ chất giải hấp phụ HNO3 2M thì hiệu suất hấp phụ đạt 100% và hiệu suất giải hấp đạt 94,5% với nồng độ ban đầu của ion Pb2+ là 200 µg/L. Với các điều kiện tối ưu, ion chì được xác định bằng phương pháp phổ nguyên tử GF-AAS với nồng độ chì theo đường chuẩn tuyến tính trong khoảng 5,0÷40,0 µg/L (r2 = 0,9998). Giới hạn phát hiện và giới hạn định lượng của phương pháp lần lượt là 0,9 µg/L và 3,0 µg/L; hiệu suất thu hồi của phương pháp khoảng 92,1%. Phương pháp được ứng dụng để xác định ion chì trong mẫu nước.
CHẾ TẠO THAN SINH HỌC TỪ VỎ SẮN PHẾ PHẨM ỨNG DỤNG LÀM CHẤT HẤP PHỤ MÀU XANH METHYLENE TRONG NƯỚC THẢI
Authors: ĐỖ QUÝ DIỄM  , BÙI DUY TUYÊN  , NGUYỄN VĂN SƠN  , VÕ THÀNH CÔNG
Published: July 2023

Trong nghiên cứu, vỏ sắn phế phẩm được nhiệt hóa yếm khí tại nhiệt độ 600 0C trong 1 giờ thu được than sinh học, ký hiệu mẫu BC-S để ứng dụng làm chất hấp phụ màu xanh methylene. Các đặc tính hình thái và cấu trúc bề mặt của BC-S được đo đạc bằng phương pháp phân tích hiện đại như là kính hiển vi điện tử quét (SEM), nhiễu xạ tia X (XRD), quang phổ hồng ngoại biến đổi Fourier (FT-IR), và Brunauer-Emmett-Teller (BET). Dựa trên kết quả phân tích cho thấy rằng hình thái bề mặt của BC-S ở dạng các hạt phẳng xếp chồng lên nhau, chứa nhiều hóc, kích thước hạt trung bình 10 µm. Cấu trúc BC-S tồn tại dạng tinh thể carbon graphite chứa các nhóm dao động C-H, C=C, S=O, N-H, CO, và OH là các peak đặc trưng của than sinh học có diện tích bề mặt riêng là 2,66 m2/g. Trong ứng dụng BC-S làm chất hấp phụ màu xanh methylene, khảo sát khả năng hấp phụ màu cho kết quả khả năng hấp phụ cực đại là 5,10 mg MB/g BC-S. Các kết quả cho thấy có thể sử dụng BC-S làm chất hấp phụ xử lý nước thải mang màu rộng rãi ở quy mô công nghiệp.
THẨM ĐỊNH QUY TRÌNH PHÂN TÍCH ĐỒNG THỜI HÀM LƯỢNG PARACETAMOL VÀ CAFEIN KHI CÓ MẶT CODEIN TRONG DƯỢC PHẨM BẰNG PHƯƠNG PHÁP QUANG PHỔ ĐẠO HÀM UV-VIS
Authors: ĐỖ THỊ LONG  , NGUYỄN THỊ MAI  , TĂNG THỊ TRÚC PHƯƠNG
Published: July 2023

Đã thẩm định quy trình phân tích paracetamol (PAR) và cafein (CAF) khi có mặt codein (COD) trong các mẫu dược phẩm bằng phương pháp phổ đạo hàm UV-VIS. Đã lựa chọn phổ đạo hàm bậc hai và bước sóng 236 nm và 292 nm là bước sóng tối ưu để phân tích PAR và CAF. Khoảng tuyến tính xác định PAR và CAF lần lượt 0.5 – 40.0 và 0.15 – 40.0 mg/L với hệ số R2 là 0.9974 và 0.9975. LOD và LOQ được xác định lần lượt là 0.07 mg/L, 0.23 mg/L và 0.10 mg/L, 0.33 mg/L đối với PAR và CAF. Phương pháp có độ lặp tốt với RSDr < 2% đối với cả chuẩn và mẫu và hiệu suất thu hồi đối với cả hai chất đều nằm trong khoảng 89 – 109% . Đã đánh giá ảnh hưởng qua lại giữa các chất đến kết quả phân tích và cho thấy phương pháp hoàn toàn phù hợp với các tỉ lệ hàm lượng dược chất thường được sử dụng. Phương pháp đã được áp dụng để phân tích một số mẫu dược phẩm trên thị trường Việt Nam và đối chiếu với kết quả tại Trung tâm dịch vụ phân tích thí nghiệm Thành phố Hồ Chí Minh (CASE).
ƯỚC TÍNH GIÁ TRỊ EC50 TRONG THỬ NGHIỆM ĐỘC CẤP TÍNH THÔNG QUA MỘT SỐ PHẦN MỀM THỐNG KÊ
Authors: NGUYỄN XUÂN TÒNG
Published: July 2023

Thử nghiệm đánh giá độc tính của hóa chất trên các loài giáp xác là mô hình được sử dụng phổ biến để ước tính nồng độ ảnh hưởng 50% (EC50) nhằm xác định những rủi ro tiềm ẩn đối với hệ thống thủy sinh. Mục tiêu của nghiên cứu là áp dụng các phần mềm thống kê trong ước tính giá trị EC50 đối với kết quả độc tính mô hình phòng thí nghiệm. Trong nghiên cứu hiện tại, giá trị EC50 của hóa chất bảo vệ thực vật (HCBVTV) Dichloro-Diphenyl-Trichloroethane (DDT) khi phơi nhiễm cấp tính (24 giờ) lên Moina macrocopa (M. macrocopa) được ước tính bằng đường cong liều – đáp ứng và bốn phần mềm thống kê như JMP Pro 16, Origin Pro 8.5.1, Sigmaplot 14.0, IBM SPSS 20. Kết quả ước tính giá trị EC50 khi áp dụng đường cong liều – đáp ứng là 25,06 (µg/L), đối với các phần mềm thống kê lần lượt là 13,48; 22,41; 25,70 và 22,55 (µg/L). Giá trị EC50 về cơ bản có sự chênh lệch giữa các phương pháp thống kê với khác biệt lớn nhất là phần mềm JMP Pro 16 (~10 µg/L). Phương trình thiết lập và hình thức phân bố dữ liệu của từng phần mềm khác nhau dẫn đến các giá trị EC50 (sai số chuẩn (SE) = 2,19 µg/L) đối với dữ liệu độc tính khác nhau. Tất cả các phần mềm thống kê đều thu được giá trị EC50, nhưng phân tích JMP Pro 16 đã chỉ ra hiệu suất tốt nhất do khả năng trích xuất các chỉ số chưa được thiết lập trong phương trình của mô hình hồi quy.