bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticancer activity of Hedyotis corymbosa nanoliposomes targeting estrogen receptor-alpha in breast cancer cells: In silico and in vitro studies
Authors: Permana Sofy , Nurzaidah Laili , Widodo Edwin , Anita Kenty W. , Nugraheni Raditya W. , Kawamoto Yoshiyuki , Endrawati Heni , Endharti Agustina T.
Published: December 2023

Context: Breast cancer expresses high levels of the estrogen receptor alpha (ER-α). Aims: To investigate the potential anticancer activity of nanoliposome Hedyotis corymbosa in breast cancer cells by specifically targeting the ER-α through a combination of in silico and in vitro studies. Methods: This study used molecular docking to analyze the interaction between ER-α and active compounds from H. corymbosa. In vitro studies, the H. corymbosa extract was converted into nanoliposomes. The nanoliposomes' characteristics were examined, combined with tamoxifen, and applied to breast cancer cell cultures. Viability, proliferation, and ER-α expression were assessed, and statistical analysis was performed (p<0.05). Results: The findings show that H. corymbosa compounds, especially rutin, inhibit ER-α binding and act as a substrate for P-glycoprotein. Extract H. corymbosa selectively decreases viability in breast cancer cells (T47D) compared to non-cancerous cells (NIH3T3). Combining extracts with tamoxifen at 10 mg/mL enhances treatment efficacy. The combined treatment is effective for up to 72 h, reducing T47D breast cancer cell proliferation. Nanoliposomes derived from extract exhibit favorable characteristics, including a spherical shape, uniform size distribution, and stability. Using these nanoliposomes at 100 μg/mL with tamoxifen significantly reduces ER-α expression (p<0.05) without affecting cell viability. Conclusions: Compounds from H. corymbosa, especially rutin, inhibit ER-α binding. H. corymbosa nanoliposomes are stable for drug delivery. Combining tamoxifen with nanoliposomes at 100 μg/mL reduces ER-alpha expression. This shows potential for breast cancer treatment, but validation through further research and clinical trials is necessary.
¿Innovar siempre es bueno? La reconversión vitivinícola uruguaya. Un estudio de caso (1974-2000)
Authors: Bonfanti Daniele
Published: December 2023

A partir de los años noventa del siglo pasado, la vitivinicultura uruguaya ha sufrido una rápida reconversión que ha seguido las pautas generales del equivalente proceso a escala mundial: transformación de las diferentes fases productivas, concentración en grandes empresas, calidad de los caldos como indicador del éxito empresarial y comercial. En este marco, existe un consenso unánime en considerar que el proceso de reconversión fue consecuencia directa de la firma del Tratado de Asunción en 1991 y de la puesta en marcha del MERCOSUR y que las empresas que mejor supieron innovar terminaron triunfando en este nuevo contexto económico. Este trabajo, centrado en el análisis de la evolución de una empresa vitivinícola concreta, Bodega Faraut, pretende poner en discusión los postulados principales de esta interpretación. Asimismo, al hallar una firma que implementó todos los criterios adecuados para adoptarse favorablemente a los supuestos de la reconversión y que, sin embargo, terminó quebrando, intenta evidenciar algunos posibles problemas relacionados a la cuestión de la innovación en el ámbito de las empresas agropecuarias.
Reseña de Andrea Lluch y Norma Lanciotti (Editoras). 2021. Las grandes empresas en Argentina. Desde la expansión agropecuaria hasta la última globalización.
Authors: Belini Claudio
Published: December 2023

Las relaciones entre las grandes empresas y el desarrollo económico constituye un tema clave de la historia y la sociología económicas, y de los estudios sobre el desarrollo. Como muestran Andrea Lluch y Norma Lanciotti, editoras de este libro, esta problemática tuvo (y continúa teniendo) un lugar central en las ciencias sociales a la hora de explicar las transformaciones de la economía capitalista a escala mundial, las trayectorias divergentes de los países que lograron industrializarse durante los siglos XIX y XX, y de aquellas economías que se insertaron de manera subordinada y dependiente en el mercado mundial.
Nota crítica sobre las IV Jornadas de Investigadores en Formación del CEEED-IIEP
Authors: Scuzzarello Camila Lucía
Published: December 2023

Durante los días 1, 2 y 3 de noviembre, se realizaron por cuarto año consecutivo las Jornadas de Investigadores en Formación del Centro de Estudios Económicos de la Empresa y el Desarrollo (CEEED) de la Facultad de Ciencias Económicas de la Universidad de Buenos Aires. En esta oportunidad, se contó con el apoyo del Instituto Interdisciplinario de Economía Política y el CONICET al igual que en ediciones previas. Gracias al esfuerzo conjunto, las prestaciones técnicas y las facilidades virtuales brindadas por ambas instituciones las jornadas se realizaron de manera exitosa. A su vez, la gran participación de investigadores se tradujo en 34 presentaciones y numerosos expositores que marcaron agenda en el ámbito de la Cultura, la Política Económica, la Historia Empresarial y la Historia de la relación entre el Estado y los mercados. Por otra parte, los comentaristas estuvieron a la altura con excelentes intervenciones que enriquecieron las ponencias en sus aspectos metodológicos y temáticos así como también en las cuestiones vinculadas a la tarea de la investigación académica.
Penguatan Perlindungan Anak Melalui Inovatif Program Pendidikan Kekerasan Seksual di Kota Soe, Nusa Tenggara Timur
Authors: Lasakar Citra Mirani , Herman Samuel , Megawaty Titin , Christianny Kurnia Catherine , Sianipar Rustida , Simanjuntak Ferry
Published: December 2023

Pemanfaatan Aplikasi Food Delivery bagi Usaha Mikro, Kecil, dan Menengah (UMKM) dalam era globalisasi akhir-akhir ini menjadi sorotan penting. Jurnal ini berfokus pada UMKM Qutis922, yang awalnya belum terdaftar pada aplikasi food delivery karena kurangnya kesadaran dan pemahaman tentang aplikasi food delivery. Tujuannya adalah untuk meningkatkan akses pasar dan efisiensi operasional. Metode pelaksanaan terdapat beberapa tahapan, mulai dari wawancara dengan UMKM, survey lokasi, hingga pendampingan pendaftaran dan penginputan data pada aplikasi food delivery yaitu Grabfood dan Shopeefood. Hasilnya menunjukkan dampak positif yang signifikan, termasuk perluasan akses pasar, peningkatan efisiensi operasional, dan meningkatnya kepuasan konsumen. Pemanfaatan aplikasi food delivery membawa manfaat bagi UMKM Qutis922 yang bisa lebih fokus pada peningkatan kualitas produk dan layanan. Secara keseluruhan, kegiatan ini bisa mengembangkan peluang usaha dan menciptakan dampak positif yang relevan terhadap UMKM di era digital.
Intervención educativa sobre factores de riesgos del embarazo en adolescentes
Authors: Sepúlveda Covarrubias Maribel , Sánchez Castillo Martha Leticia , Hernández Nava Imelda Socorro
Published: December 2023

El embarazo en la adolescencia es una problemática que, aunque sus cifras han disminuido respecto a años anteriores, sigue siendo un tema recurrente en nuestra población, además de las complicaciones en la salud de la joven madre y el bebé que pueden presentar durante su embarazo. Evaluar una intervención educativa sobre factores de riesgo del embarazo en adolescentes de la Universidad Autónoma de Guerrero. se realizó un estudio de intervención educativa con diseño cuantitativo descriptivo, longitudinal de pre y post Test, la muestra fue estratificada, según el tamaño de los estratos, para medir el conocimiento sobre factores de riesgo durante el embarazo, en adolescentes de Chilpancingo Guerrero. El nivel de conocimiento sobre riesgo biológico antes de la intervención fue de 37.8% conocimiento bueno y después de la intervención incrementó a 76.6%, el conocimiento del riesgo psicológico incremento de 52.2% a 79.8% de conocimiento bueno, respecto al conocimiento socioeconómico mostró un aumento en el nivel de “conocimiento bueno” con 84.0% después de la intervención. De manera general se puede afirmar que la intervención educativa aplicada a estudiantes de la Universidad Autónoma de Guerrero fue efectiva ya que se notó un incremento significativo sobre los factores de riesgo biológico, psicológico y socioeconómico del embarazo en adolescentes que participaron, demostrando así la efectividad de la intervención educativa.
Niño/a, obsérvate, tócate y conoce tu cuerpo: Juego educativo anatómico-fisiológico con perspectiva de género e identidad (3 a 6 años)
Authors: Tenorio Obregón Alfredo Nicolás
Published: December 2023

El presente artículo de revisión bibliográfica, se planteó como objetivo, Analizar la metodología de enseñanza-aprendizaje sobre los caracteres anatómicos - fisiológicos del infante, mediante juegos educativos del, obsérvate, tócate y conoce tu cuerpo, para que docentes y padres de familias, orienten al niño/a de 3 a 6 años, en el reconocimiento de su género e identidad sexual. Es un trabajo de enfoque cualitativo documental, de tipo analítico y hermenéutico; se revisó y analizó de manera rigurosa y exhaustiva diferentes fuentes bibliográficas, del buscador Google académico, en base de datos: RELADYC, eLibro, Medline, Scopus, SciELO Analytics, LILACS , Latindex, La Web of Science; determinándose que la implementación del juego del obsérvate, tócate y conoce tu cuerpo, como estrategia educativa, es la más adecuado que, unida al reflejo de la imagen del cuerpo (espejo), los niños/as observan, exploran y palpan con sus propios sentidos su anatomía, y así van desarrollando, habilidades cognitivas, sensoriales, afectivas y emocionales, creando autonomía de manejo y cuidado de su cuerpo; a identificarse consigo mismo, y diferenciarse de los otros/as, logrando él mismo, el reconocimiento y aceptación de su orientación sexual e identidad o de su género, estrategia que se la puede realizar en los centros infantiles, como en los hogares supervisado por docentes y padres de familias.
CLINICAL CASE OF DIPHYLLOBOTHRIOSIS
Authors: Александров П.А. , Лавров Н.В. , Искалиева А.Р.
Published: December 2023

Дифиллоботриоз — один из самых распространенных гельминтозов на территории Северного полушария. В Российской Федерации частота встречаемости дифиллоботриоза колеблется от 10 до 180 на 100 тыс. населения. Среди заболевших преобладают взрослые и подростки, однако в последнее время участились случаи заражения детей младшего возраста. Вследствие неполного сбора анамнеза, недооценки данных лабораторных исследований диагноз дифиллоботриоза устанавливается поздно. Отсроченное начало противопаразитарной терапии и отсутствие доказательной базы относительно подбора дозы празиквантела для детей младше 4 лет делают проблему еще более актуальной. В данной работе представлен нераспознанный на первичном этапе оказания медицинской помощи клинический случай дифиллоботриоза у ребенка 3,5 лет. Авторы статьи обращают внимание читателей на важность клинической интерпретации лабораторных данных в соответствии с имеющейся клинико-эпидемиологической ситуацией и делятся опытом успешного подбора терапевтической дозы празиквантела при лечении дифиллоботриоза у детей младше 4 лет.

Diphyllobothriasis is one of the most common helminthiases in the Northern Hemisphere and in particular the Russian Federation (from 10 to 180 per 100 thousand population). Among the sick, adults and adolescents predominate, but cases of infection of young children have recently become more frequent. This publication presents a clinical case of diphyllobothriasis in a 3.5-year-old child, unrecognized at the primary stage of medical care. The described clinical case is an example of the fact that insufficient history taking and underestimation of general laboratory data can lead to delayed diagnosis and late initiation of antiparasitic therapy. There is also insufficient scientific evidence regarding the selection of a therapeutic dose of Praziquantel for children under 4 years of age. The purpose of the described case is to draw the attention of physicians (primary care and not only) to the thoroughness of taking an anamnesis (including epidemiological) and to the clinical interpretation of laboratory data in accordance with the existing clinical and epidemiological situation, to assist physicians in the treatment profile in selecting an adequate dose of Praziquantel in case of treatment of children under 4 years of age.
Analisis Pendapatan Pengemudi Ojek Online Maxim-Bike
Authors: Mariano Enjelita , Amkeun Viviana , Bau Novita , Lian Yohanes Pemandi
Published: December 2023

Tujuan Penelitian ini adalah untuk mengetahui pendapatan pengemudi ojek online Maxim-Bike di wiliyah oeba, kota kupang. Jenis penelitian ini yaitu deskriptif kualitatif. Metode pengumpulan data dalam penelitiaan ini menggunakan data primer dengan cara obeservasi, wawancara dan dokumentasi terhadap responden. Hasil penelitian menunjukkan bahwa ada 2 kategori pendapatan driver maxim bike. Kategori pertama pendapatan driver maxim bike yang menjadikan pekerjaan driver Go-Jek sebagai pekerjaan utama yang mendapatkan pendapatan bersih dengan kisaran antara Rp. 1.500.000 s/d 2.000.000 setiap bulan. Kategori kedua pendapatan driver Go-Jek yang menjadikan pekerjaan sampingan mendapatkan pendapatan berkisar Rp. 500.000 s/d Rp. 1.000.000 setiap bulan.
Evaluation of Relapse Risk Factors and Treatment Outcomes in Stage 1 Germ Cell Testicular Tumors
Authors: DUZKOPRU Yakup , KOÇANOĞLU Abdülkadir , GÜLCÜ Serkan
Published: December 2023

Aim: This study aims to evaluate risk factors for relapse in stage 1 germ cell tumors (GCTs) and compare relapse and survival outcomes between treated and untreated patients.

Method: The study encompasses patients diagnosed with GCTs aged 18 and above, treated and monitored at our oncology clinic between 2012 and 2022. After excluding cases with secondary malignancies, 54 patients with confirmed histopathological stage 1 testicular tumors were analyzed. Patient data, treatment received, and follow-up information were recorded, and statistical analyses were performed using IBM SPSS Statistics version 22.0.

Results: In the seminoma subgroup, relapse was observed in 3 out of 24 (12.5%) patients. Although there was no statistically significant difference in terms of relapse between the groups with and without risk factors such as rete testis involvement and tumor diameter, it was observed that relapse occurred at a higher frequency in both risk groups. Among non-seminomatous tumors, 5 out of 30 (16.7%) patients experienced relapse. Although a notable numerical difference in lymphovascular invasion —a defined risk factor—was observed, statistical significance was lacking. A significant difference in relapse was observed between patients receiving adjuvant treatment and those who did not.

Conclusion: For both seminoma and non-seminomatous tumors at stage 1, surveillance is recommended for patients lacking identified risk factors. Nevertheless, patients with established risk factors warrant personalized consideration, weighing factors such as age, comorbidities, and preferences to guide treatment decisions.
Digitization and Archiving of Company Invoices using Deep Learning and Text Recognition-Processing Techniques
Authors: GUNAYDIN Ensar , GENCTURK Bunyamin , ERGEN Cuneyt , Koklu Murat
Published: December 2023

Nowadays, it is crucial to transfer official documents such as invoices, dispatch notes, and receipts into digital environments and establish correct semantic relationships. However, understanding and processing these documents is a difficult process that requires significant time and effort. In recent years, the use of deep learning, image preprocessing, text detection, and optical character recognition (OCR) technologies have made this process easier. However, for text recognition and processing techniques to produce accurate results, documents must be clean and readable. Additionally, difficulties arising from time-consuming, tiring, error-prone, and cost-incurring human-powered digitalization processes must be reduced. The aim of this study is to digitize and archive scanned invoices and similar official documents using current artificial intelligence technologies, thereby enabling the most effective use of components such as time, cost, and human resources. The dataset used in the study includes 10,000 ".jpg" image files and 10,000 ".xml" data files. The model trained with the ResNet-50 architecture can detect text with accuracy rates of up to 97% on randomly selected images from the dataset. In an environment where a person can process an average of 2,112 documents per month, it is predicted that the trained artificial intelligence model can process 108,000 documents per month. With this developed method, businesses can quickly digitize and archive official documents such as invoices, dispatch notes, and receipts. Future studies propose the development of new methods that can produce better results using larger and more diverse datasets.
ANALYSIS ON THE CIVIL MILITARY COORDINATION FOR DISASTER RESPONSE IN KUALA LUMPUR
Authors: Nordin Nadhirah , Musa Kutty Norhazlina Fairuz , Fazan Ahmad Noor Diyana
Published: December 2023

A successful disaster response requires great coordination between the military and rescue aid agencies to minimize casualties and losses suffered by victims. The collaboration between agencies and the military during a disaster response needs to consider the issues of coordination, communication, and roles responsibilities in order to ensure that disaster response operations are well-structured and prevent duplication of task. In addition, the findings of the study also show that community awareness factors also influence the effectiveness during disaster response activities. Response to disasters requires an understanding of the factors that affect civil-military coordination. In order to accomplish the research objectives, a sample size of ten respondents was selected for the qualitative research method. Interviews were conducted with ten representatives from each agency involved in Disaster response in Kuala Lumpur. However, thematic network analysis and narration and observation were used for data analysis. The study found that each of the identified elements greatly influenced the effectiveness of civilian-military coordination during disaster response operations. This study contributes in equipping the agencies and the military to respond to disasters systematically.
Impuissant ou vérolé : écrire la défaillance masculine dans la poésie française à la première personne (xive-xvie siècle)
Authors: Brouzes Camille , Laubner Jérôme
Published: December 2023

Cet article examine la question de la santé sexuelle masculine dans des formes poétiques à la première personne composées entre la seconde moitié du xive siècle et le xvie siècle. Si le découpage séculaire des études littéraires empêche souvent de considérer ces corpus ensemble, la présente étude compare les textes sur l’impuissance et ceux sur la maladie vénérienne appelée la grosse vérole ou la syphilis et observe la proximité des discours en matière de défaillances masculines. L’article révèle ainsi comment la posture du mâle infirme permet aux poètes d’afficher une verve inventive qui, à l’inverse de la langue plus sérieuse des médecins, parvient à amuser et prévenir une communauté masculine clairement ciblée comme public de prédilection de ces poèmes obscènes et volontiers misogynes.
Médecine et transhumanisme dans la littérature contemporaine : limites d’un genre et d’une pratique
Authors: Alloun Mohamed Sami
Published: December 2023

Cet article étudie le traitement des pratiques médicales et de leur évolution dans la littérature du posthumain. Olga Lossky, dans Risque zéro (2019), et Mireille Gagné, dans Le Lièvre d’Amérique (2020), accordent une place centrale à la question du dépassement de l’humain. Cette question est, comme nous le montrent ces deux romans, indissociable de celle de la métamorphose – voire de la disparition ‒ de la médecine moderne.
Stock Market Integration and Corporate Investment in Nigeria: A Critical Analysis
Authors: NEJO, Femi MIchael
Published: December 2023

Low level of corporate investment in Nigeria coupled with poor financial base of a single stock exchange market system bring the need for the study to critically examined the effect of stock market integration on corporate investment in Nigeria from 1986 to 2022. The study adopted Augmented Dickey Fuller (ADF) unit root test and Auto-regressive Distributed Lag (ARDL). The data used for this study were collected from the Central Bank of Nigeria, Statistical Bulletin (2022).  The ADF showed that the real exchange rate, lending interest rate, and trade openness were all integrated of order zero (∆ = 0); while, stock market integration and corporate investment were integrated of order one (∆ = 1). The ADF result showed that stock market integration exhibited a non-stability trend over the years, real exchange rate showed a negative sign but non-significant at 5%; while, lending interest rate and trade openness was negative and significant. The study concluded that stock market integration was volatile over the years which limited the rate of impacting corporate investment in Nigeria; while, lesser interest rate and trade liberation promote corporate investment. The study recommended that in order to fast ease stock market integration, which is crucial for economic progress, the Nigerian Exchange Group NGX should aim toward ensuring that each listed firm on the market have a strong market capitalization through encouraging different ownership structure to possess their respective stock value
SARCOMA DE KAPOSI CON AFECTACIÓN VISCERAL EN PACIENTE CON VIH: REPORTE DE UN CASO
Authors: Blanco Aguilar Andrés Camilo
Published: December 2023

Kaposi's sarcoma (KS) is a rare multifocal angioproliferative neoplasm of endothelial cells with predominantly cutaneous involvement. It was first described in 1872 by Moritz Kaposi. Four groups of KS have been classically described: classic, epidemic or AIDS-associated, iatrogenic and endemic. KS is the most frequent neoplasm associated with AIDS-associated human immunodeficiency virus (HIV) and occurs most frequently in the cephalic region (eyelids, nose and ears). This article describes the case of a 31-year-old male patient diagnosed with HIV and Kaposi's sarcoma with visceral involvement.
Uterine rupture
Authors: Felis S
Published: December 2023

The increasing rate of elective and indicated caesarean sections worldwide has led to new pathologies and management challenges. The number of patients undergoing trial of labor after caesarean section (TOLAC) is also increasing. Three professional societies provide detailed guidelines based on scientific evidence for the management of patients attempting vaginal birth after caesarean section (VBAC). However, they do not provide any recommendations for the actual surgical steps to be followed to minimize the risks of uterine rupture (UR) during TOLAC. Uterine scar condition, intrapartum management and maternal health status correlate to uterine scar rupture risk and provide guidance for parturient TOLAC eligibility. TOLAC and vaginal delivery success rate as reported by the largest studies is between 60% and 77%. Uterine rupture is more prevalent in VBAC-2 patients (1.59%) in contrast to VBAC-1 (0.72%). Additionally, VBAC-2 patients have higher incidence of caesarean hysterectomy 0.56% vs. 0.19% for VBAC-1. The chances of successful VBAC increase when the interpregnancy/interdelivery interval is less than 6.3 years and less than 24 months, respectively. No difference was detected between the techniques of uterine incision closure of the previous CS and TOLAC results, although closure of the CS uterine incision in 2 layers seems to be practiced more widely. Niche or isthmocele presents another complication of CS. Secondary infertility due to niche, will eventually direct to hysteroscopic or laparoscopic repair, depending on the residual myometrial thickness (RMT) as measured by US scan. When RMT is below 3 mm or 2.5 mm surgery can be performed, to prevent any spontaneous UR in case of pregnancy. Monitoring by US scanning of hysterotomy scar after myomectomy can detect hematoma. In patients with severe postoperative pain but hemodynamically stable follow up by US scan examination can direct the management decision. In those patients with active bleeding and deterioration of hysterotomy scar edema will be an indication to surgery. There is no firm evidence regarding which type of thread, knotting or sequence of suturing is more favorable to reduce the risk of UR after VBAC or hysterotomy after myomectomy.
Volvulus of the Small Intestine in adults with intestinal malrotation: case report
Authors: JAMALEDDINE Khalid , HAJRI Amal , ELWASSI Anas , ERGUIBI Driss , BOUFETTAL Rachid , RIFKI JAI Saad , CHEHAB Farid
Published: December 2023

Introduction: The volvulus of the small intestine with intestinal malrotation is a rare disease when occuring in adults, though, a surgeon’s ignorance of this diagnosis can result in potentially fatal extensive small intestinal necrosis. Presentation of case: Here, we present the case of a 57years old woman admitted and operated for a volvulus of the small intestine with intestinal malrotation after radiographic and pre-operative confirmation, whom follow up was unmarked. Discussion: The usual mechanism of obstruction in the volvulus of the small intestine with intestinal malrotation is adhesive compression of the duodenum and volvulus of the small intestine, this condition is the result of an arrest in the normal counterclockwise rotation of the cecum from the left lower quadrant to the right upper quadrant. Pre-operative diagnosis not always an easy task but the abdominal CT-scan is with a great help mainly by identifying the "WHIRL-WIND" sign. The Ladd procedure, consisting of division of Ladd’s bands, widening of the mesentery, and incidental appendectomy, is considered the worldwide standard up til now. Conclusion: This condition is rare and can be diagnosed mainly by CT-scan, however,the surgical management worldwide standard is the Ladd's procedure which can be led by laparotomy or laparoscopy and results in great outcome.
Hydrocephalus and Dandy-Walker syndrome. Clinical case
Authors: Villalobos-Rodríguez Alejandro L.
Published: December 2023

Introduction. Dandy-Walker syndrome (DWS) is a developmental abnormality characterized by dilated posterior fossa, cystic enlargement of the fourth ventricle, hypoplasia of cerebellar vermis, and its upward rotation. The affected person may suffer from psychomotor retardation, ataxia, apnea attacks, muscle weakness, occasional muscle spasm, seizures, nystagmus, and macrocephaly. However, half of the cases have average intelligence. Clinical Case. Male newborn at 36 weeks gestation obtained by cesarean section, with a history in the current pregnancy of poor prenatal control. During the fifth month of pregnancy, an ultrasound established a diagnostic suspicion of massive ventriculomegaly. At the sixth month, thinning of the cerebral cortex compression of the cerebellum in the posterior fossa was detected, and a possible ruling out of chromosomopathy related to Dandy-Walker Syndrome was suggested. Discussion. Neurologically, this disease causes multiple anomalies, such as Hemorrhagic Stroke in a Young Adult with Undiagnosed Asymptomatic Dandy–Walker Malformation (5). The embryonic development of the cerebellum and fourth ventricle causes the tentorium to be displaced upwards, and the posterior fossa enlarges. The association of hydrocephalus with DWS is due to blockage of normal cerebrospinal flow, leading to an excessive amount of fluid accumulating in and around the brain and causing an increase in intracranial pressure and head circumference, which ultimately causes neurological impairment. Conclusions. The prognosis of patients with this syndrome depends on the association with intra/extracranial malformations. Early diagnosis of central nervous system abnormalities is considered one of the first objectives of obstetric ultrasound.
Uterine leiomyosarcoma in a premenopausal woman. Clinical case
Authors: L. Villalobos-Rodríguez Alejandro
Published: December 2023

INTRODUCTION. Leiomyosarcoma (LMS) of the uterus is a rare soft‑tissue tumor of the female pelvis with <1% of uterine tumor. It usually arises from the uterine myometrium de novo or is very rarely transformed from a preexisting benign leiomyoma. These tumors are found mainly in females 40–60 years of age. Leiomyomas seen in the reproductive age group and a strong suspicion of LMS should be in mind in cases of fibroid with postmenopausal bleeding. CLINICAL CASE. A 39-year-old female came to the emergency room complaining of pelvic pain of 8 days duration, treated symptomatically with NSAIDs. It has the following background: hereditary family history, which is unimportant to the case. Gynecobstetric history: menarche 11 years old, regular cycles five to seven days, reports two months with uncontrolled cycle with heavy menstrual bleeding, start active sexual life 24 years old. Papanicolaou: last year reported normal; colposcopy last one and a half ago reported normal. DISCUSSION. Approximately 40-80% of women may develop leiomyomas, the most common benign gynecological disease, during their lifetime. Uterine sarcoma, on the other hand, is a rare disease with an incidence ranging from 1.55 to 1.95 per 100,000 women per year. According to the WHO, in 2011, a LMS is a specific type of rare sarcoma that accounts for over 60% of all cases of uterine sarcoma. It is essential to correctly evaluate myometrial tumors before surgery to ensure proper patient management and avoid delayed treatment. However, distinguishing an LMS from fibroids can be difficult due to similar clinical, laboratory, and ultrasound features. Ultrasound is a cost-effective, non-invasive, and widely accepted imaging method for evaluating the myometrium. The reporting of ultrasound characteristics of the myometrium and myometrial lesions was standardized by developing a consensus statement by the Morphological Uterus Sonographic Assessment group.
Clinical management and therapy of secondary postpartum hemorrhage
Authors: Felis S
Published: December 2023

Secondary postpartum hemorrhage, defined as excessive bleeding that occurs more than 24 hours after delivery and up to 12 weeks postpartum, occurs in approximately 1% of pregnancies. In the event of secondary hemorrhage, several specific etiologies should be considered. Uterine atony (perhaps secondary to retained products of conception) with or without infection contributes to secondary hemorrhage. Ultrasound evaluation can help identify intrauterine tissue. Endometritis should be strongly suspected in the presence of uterine tenderness and a low-grade fever. Secondary postpartum hemorrhage also may be the first indication of bleeding disorders such as von Willebrand disease. Treatment should be focused on the etiology of the hemorrhage and may include uterotonic agents and antibiotics, but if these fail to resolve the problem or if retained products of conception are suspected, uterine curettage may be necessary. If treating endometritis, broad antibiotic coverage with clindamycin and gentamicin is a common choice, although other combinations also are used. Often the volume of tissue removed by curettage is relatively small yet bleeding usually subsides promptly. Concurrent ultrasound assessment at the time of curettage can help prevent uterine perforation. Patients should be counseled about the possibility of hysterectomy before initiating any operative procedure
Obstetric Perineal Trauma and Episiotomy
Authors: Felis S
Published: December 2023

Obstetric lacerations are a common complication of vaginal delivery. Lacerations can lead to chronic pain and urinary and fecal incontinence. Perineal lacerations are defined by the depth of musculature involved, with fourth-degree lacerations disrupting the anal sphincter and the underlying rectal mucosa and first-degree lacerations having no perineal muscle involvement. Late third-trimester perineal massage can reduce lacerations in primiparous women; perineal support and massage and warm compresses during the second stage of labor can reduce anal sphincter injury. Conservative care of minor hemostatic first- and second-degree lacerations without anatomic distortion reduces pain, analgesia use, and dyspareunia. Minor hemostatic lesions with anatomic disruption can be repaired with surgical glue. Second-degree lacerations are best repaired with a single continuous suture. Lacerations involving the anal sphincter complex require additional expertise, exposure, and lighting; transfer to an operating room should be considered. Limited evidence suggests similar results from overlapping and end-to-end external sphincter repairs. Postdelivery care should focus on controlling pain, preventing constipation, and monitoring for urinary retention. Acetaminophen and nonsteroidal anti-inflammatory drugs should be administered as needed. Opiates should be avoided to decrease risk of constipation; need for opiates suggests infection or problem with the repair. Osmotic laxative use leads to earlier bowel movements and less pain during the first bowel movement. Simulation models are recommended for surgical technique instruction and maintenance, especially for third- and fourth-degree repairs.
Analisis Tingkat Kesehatan Bank Melalui Laporan Keuangan Periode 2017-2021 Dengan Menggunakan Metode Perhitungan CAMEL
Authors: Nur Sa’idaturrohmah  , Nurwinsyah Rohmaningtyas  , Zamrotin Aulan Nisak
Published: December 2023

Banks are an important element of the state in improving people's living standards. Because with banks, people can collect and distribute money easily and efficiently. Therefore, the health of a bank needs to be considered so that its operational conditions can run in accordance with procedures. The purpose of this study is to analyze the health of NTB Syariah banks from the 2017-2021 financial statements. The method used in this study is quantitative descriptive using the CAMEL (Capital, Assets, Management, Equity, Liquidity) calculation method. The result of this study is that the condition of the NTB bank after calculation analysis has a very healthy condition in several ratios. But in addition to very healthy health conditions, there are also those who are in a healthy condition only, there are also those who enter the specifications of conditions that are quite healthy in several other calculation ratios. Therefore, it is hoped that this NTB bank can improve its operational activities to be even better in the future, so that it can also improve the level of health in the bank.
Kajian Analisis Strategi Belajar Pada Anak Berkebutuhan Khusus Jenjang Sekolah Dasar (SD)
Authors: Qolbie Lu’luil , Imroatun Imroatun , Hanifah Balqis Mutiara , Munawaroh Hidayatul
Published: December 2023

Children with special needs (ABK) have different characteristics from one another. Therefore, children with special needs must have special educational services that are tailored to the abilities possessed by these children according to their potential. Inclusive education is an education system intended for children with special needs. With the meaning of inclusive education as a system of providing education to students who have abnormalities and potential intelligence or special talents, ABK has different potential abilities. In this way the learning strategy that is applied to ABK is the application of remedial teaching learning which helps teachers understand and set certain conditions in learning.
Kesalehan Pragmatis dan Kesalehan Etis
Authors: Sutikno Sutikno
Published: December 2023

This article focuses on the teachers existential battle in the contemporary educational globalization especially Islamic education which is faced to the aspects of ethical piety and pragmatical piety values. This piety just not as given identity but is founded on consciousness and reason structures of the teachers. This piety creates and implicates risk and consequence for the process of teacher existencialism and future of Islamic education. An attempt to Islamic principles and values on the essence of teacher become an alternative resolution in order to escape from existencial ambivalence and ambiguity in the process of educational globalizations. Those Islamic priciples and values in the origins of Islamic history and traditions able to become rational and trancendental paradigm in the modern and postmodern times.
Strategi Kepala Madrasah dalam Meningkatkan Prestasi Siswa di Madrasah Ibtidaiyah Unggulan Sabilillah Lamongan
Authors: Widianto Suheri , Al-Kadhafi Muhammad Jamaluddin
Published: December 2023

Education is a conscious and planned effort to create a learning atmosphere and learning process so that students actively develop their own potential, personality, intelligence, noble character, and the skills needed by themselves, society, nation and state. Indonesian National Education based on Pancasila aims to develop the potential of students to become human beings who believe in and fear God Almighty, have noble character, are healthy, knowledgeable, capable, creative, independent, and become citizens of a democratic and responsible country.The success of a nation can be seen from the extent to which its people take education. The higher the education pursued by the community, the more advanced the nation will be. Quality education is the key to building competent human beings and producing graduates as expected. In realizing quality education, it is necessary to implement programs that focus on improving the quality and activities of education in schools.Quality Education is not only seen from the quality of its graduates, but includes the efforts made by the School to meet educational needs in accordance with applicable quality standards. In realizing quality education, a leader who has a strong mentality is needed, is able to overcome various problems and obstacles, and has the courage to make educational innovations.In school management, the school principal, according to his function, can understand the needs of the school he leads so that teacher competence is not only the competence he had before, but can increase and develop in a better direction so that teacher professionalism will be realized. And also the Principal as a leader or a good leader must be able to strive to increase student achievement.The increase in achievements that have been achieved as evidenced by the many achievements in the Sabilillah Lamongan Superior Madrasah Ibtidaiyah School, Sabilillah Lamongan Superior Madrasah Ibtidaiyah (MIUS) which stands under the auspices of the Sabilillah Lamongan Foundation. Accredited "A". MI Unggulan Sabilillah is located on Jl. Sumargo No. 1A Lamongan. This educational institution was founded in 2008. It was established as an alternative answer to the educational problems that developed in the community. who think Madrasah Ibtidaiyah cannot compete with State Institutions.
IDENTIFIKASI PERUBAHAN AREA PERTAMBANGAN MENGGUNAKAN CITRA SATELIT LANDSAT DENGAN MACHINE LEARNING PADA GOOGLE EARTH ENGINE DI KECAMATAN CIPATAT, KABUPATEN BANDUNG BARAT
Authors: Lumban Raja Denny
Published: December 2023

Kegiatan pertambangan dan industri pertambangan kapur menimbulkan dampak positif dan negatif bagi masyarakat di Kecamatan Cipatat, Kabupaten Bandung Barat. Kemajuan teknologi dalam analisis citra satelit semakin mengarah pada pemanfaatan cloud computing dan big data seperti dalam implementasi Google Earth Engine (GEE) dalam klasifikasi lahan. Pengambilan keputusan yang cepat perlu didukung oleh penyajian data yang cepat dan akurat pula. Melalui teknologi machine learning maka permasalahan tersebut menjadi salah satu solusi yang tepat. Tujuan dari penelitian ini adalah untuk mengidentifikasi lahan pertambangan menggunakan machine learning di Kecamatan Cipatat, Kabupaten Bandung Barat. Metode yang digunakan adalah analisis klasfikasi terbimbing dengan algoritma Classification and Regression Trees (CART) dan Random forest menggunaan GEE. Hasil penelitian menunjukkan luas area dari masing-masing algoritma yaitu sebesar 8.178 Km2 atau 6,8% dan 20.959 Km2 atau 17,62%. Nilai overall accuracy dengan algoritma random forest lebih baik yaitu sebesar 93.2% dibandingkan dengan algoritma CART yaitu sebesar 91.5 %. Hasil penelitian ini dapat digunakan dalam pemantauan perkembangan area pertambangan dan sebagai salah satu pertimbangan dalam pengambilan kebijakan pada kegiatan pertambangan oleh pemerintah Kabupaten Bandung Barat, Jawa Barat.
GEOLOGI DAN MODEL KOLABORASI PENGEMBANGAN GEOPARK IJEN, DI KABUPATEN BANYUWANGI
Authors: Rohaendi Nendi , Setiawan Iwan Fahlevi , Budiyono Arif , Harmoko Alex Antonius , Wahyudi Wahyudi
Published: December 2023

Daerah Banyuwangi memiliki keistimewaan dari sisi geologi dan mineralisasi, hal ini dibuktikannya dengan adanya penetapan sebagai geopark ijen dan adanya perusahaan tambang. Tujuan penulisan artikel ini adalah untuk menggambarkan potensi geopark Ijen dalam pengembangan geowisata di kawasan Banyuwangi. Geopark dipahami sebagai paduan dari keragaman geologi (geodiversity), keanekaragaman hayati (biodiversity), dan keragaman budaya (cultural diversity). Pengelolaan geopark bertujuan untuk keperluan konservasi, pendidikan, dan ekonomi secara berkelanjutan, dengan melibatkan secara aktif masyarakat dan pemerintah, sehingga pada akhirnya dapat digunakan untuk menumbuhkan pemahaman dan kepedulian masyarakat terhadap bumi dan lingkungan sekitarnya. Hasil penulisan ini adalah gambaran umum potensi geowisata di kawasan Banyuwangi dan pengembangan ekonominya.
Assessement of the Influence of Baking Fuel Types on the Residues of Some Heavy Metals in Selected Bread from Jalingo, Taraba State
Authors: Tutuwa Jummai Adamu , David Bando Christopher , Tadawus Rejoice Habila , Ifraimu Daniel , Aigbogun Blessing Smart , Nuhu Imbasire , Jesse Polly Shingu , Agbu Tsoken Danji
Published: December 2023

Method of food processing and handling plays pivoted role in its contamination. This research was geared towards assessing the level at which food handling and production processes influence metallic contamination. Samples of flour and baked bread (electric or coal oven) were sourced from market and bread bakeries within Jalingo metropolis. Heavy metals (Lead, Cadmium, Chromium, Nickel, Iron, and Zinc) analysis of the samples was done using Atomic Absorption Spectrophotometer (AAS). Bread baked using coal oven were observed to show elevated level of metallic contamination over those baked using electric oven with Iron (Fe) showing a statistical significant increase at p<0.05 while Cadmium (Cd) was not detected in bread baked using both fuel source. Both electric and coal baked bread were analyzed to have more metallic deposition when compared to the flour. Although, the heavy metals contamination were within the range of FAO/WHO permissible limit but long term consumption of such food products could lead to bioaccumulation in the biological system and becomes injurious to health.
Education Mind, Volume 2, Issue 2
Authors: Mind Education
Published: December 2023

Education Mind, Volume 2, Issue 2
Desplazamiento activo al centro educativo y las influencias del entorno físico social y hábitos de estilo de vida en adolescentes españoles
Authors: Pinilla-Quintana Iván , Martín-Moraleda Evelyn , Jiménez-Zazo Fabio , Martinez-Romero Maria Teresa , Dorado-Suárez Alberto , Romero-Blanco Cristina , García María Virginia , Cabanillas Esther , Mota-Utanda María del Carmen , Queralt Ana , Herrador-Colmenero Manuel , Casttro-Lemus Nuria , Santos Maria Paula , Chillón Palma , Molina-García Javier , Sallis James F , Mandic Sandra , Aznar Susana
Published: December 2023

Objetivos: Analizar los medios de desplazamiento escolar y las influencias del entorno físico y psicosocial (influencia familiar y otras influencias significativas como la de los iguales) así como la influencia de otros hábitos del estilo de vida (patrones de sueño, horas de pantallas y aspectos nutricionales) en el desplazamiento al/desde el centro educativo de adolescentes de Toledo, Granada, Sevilla y Valencia. El Proyecto PACOyPACA consiste en un estudio transversal. La muestra estuvo formada por estudiantes de 3º de Educación Secundaria Obligatoria (ESO) de 4 ciudades españolas (Toledo, Granada, Valencia y Sevilla) y por sus padres. Para garantizar la representatividad de la muestra, se seleccionaron aleatoriamente centros educativos atendiendo al nivel socioeconómico (NSE) y el índice de “caminabilidad” del vecindario en el que se ubican. El proyecto PACOyPACA servirá para adquirir conciencia sobre el estado actual del desplazamiento activo al centro educativo (DACE) en la adolescencia y los posibles factores que influyen sobre él. Estos conocimientos permitirán una mejor interpretación de la situación actual y será útil para el diseño y creación de estrategias con el fin de fomentar el DACE. Dichas estrategias permitirán la creación de una guía para impulsar iniciativas utilizando el centro educativo como punto clave de la acción.
BMX Race: Perfil psicosocial de deportistas orientados al rendimiento deportivo.
Authors: Marcén Muñío Celia , Aguilera Ana , Arbonés-Arqué Irela
Published: December 2023

El objetivo de este estudio fue elaborar el perfil psicosocial de los deportistas de competición de BMX Race. Dada la carencia de literatura previa se optó por instrumentos autoinforme que permitieran valorar un amplio rango de variables, desde una perspectiva del ecosistema deportivo, considerando al deportista, el entrenador y la familia. La muestra estuvo compuesta por 28 corredores de BMX, todos ellos con experiencia en eventos internacionales. Los resultados muestran la evolución que las habilidades psicológicas implicadas en el rendimiento, el estilo de liderazgo preferido, el apoyo familiar y el equilibrio entre la toma de decisiones de riesgo y la de comportamientos precautorios varían con la edad, la experiencia y el nivel deportivo, sin encontrarse diferencias significativas por sexo. Como conclusión se destaca la relevancia de incorporar la perspectiva psicosocial al entrenamiento de BMX Race para lograr mejores resultados y un mayor bienestar de los deportistas. Este trabajo resulta un avance en una modalidad muy escasamente analizada científicamente, así como en el asesoramiento y formación de los técnicos deportivos
Práctica de actividad física y nivel de adherencia a la dieta mediterránea en estudiantes universitarios
Authors: Díaz-Quesada Gema , Muñoz-Galiano Inés M , Escarabajal-Arrieta Mª Dolores , Torres-Luque Gema
Published: December 2023

Introducción: La práctica de actividad física (AF) es determinante en un estilo de vida saludable; unido a otros hábitos fundamentales como el tipo de alimentación. Objetivo: analizar la práctica de actividad física diaria en función del nivel de adherencia a la dieta mediterránea en estudiantes universitarios. Metodología: Se seleccionaron 40 estudiantes universitarios (19.13 ± 3.27 años), los cuales portaron la pulsera de AF Xiaomi Mi band 4 durante 7 días consecutivos registrando los minutos de actividad física moderada-vigorosa (AFMV) y el volumen de pasos. Se administró el cuestionario KIDMED para determinar el nivel de adherencia a la DM. Resultados: Los sujetos con media adherencia a la DM muestran más volumen de AF el fin de semana y el total de la semana, respecto al grupo de baja adherencia a la DM. Conclusión: Los estudiantes universitarios con una baja adherencia a la DM tienen una tendencia a realizar menos volumen de AF; lo que podría ser un punto de partida para la promoción de hábitos saludables desde programas universitarios.