bluuebunny/crossref_metadata_2025 huggingface dataset:
Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
Authors: Li Shan , Zhang Lihai , Li Shuhua , Zhao Hengyi , Chen Yonggang
Published: September 2021

Curcumin has been demonstrated to be an anti-tumor agent in many types of cancers, including gastric cancer (GC). However, the molecular mechanisms by which curcumin performs its anti-tumor effects remain elusive. circ_0056618 and miR-194-5p are reported to be involved in GC progression, but their relationships with curcumin are unclear. In this study, circ_0056618 was elevated, and miR-194-5p was reduced in GC tissues and cells. Curcumin treatment led to a decrease in circ_0056618 level in GC cells. Overexpression of circ_0056618 promoted cell proliferation, migration, and invasion and suppressed cell cycle arrest and apoptosis in curcumin-treated GC cells. Moreover, miR-194-5p was identified as the target of circ_0056618, and its expression in GC cells increased after curcumin treatment. Overexpression of miR-194-5p reversed the promotional effect of circ_0056618 on cell progression in curcumin-treated GC cells. Additionally, curcumin treatment repressed the tumorigenesis of GC in vivo through regulating circ_0056618. Curcumin treatment delayed the development of GC partly through decreasing circ_0056618 and increasing miR-194-5p.
Peredur and the Problem of Inappropriate Questions
Authors: Petrovskaia Natalia I.
Published: September 2021

This article reopens the question of the relationship between the medieval Welsh version of the Grail narrative, the Historia Peredur vab Efrawc, and the French Conte du Graal of Chrétien de Troyes. It explores the seeming inconsistencies in the Welsh tale’s presentation of the Grail procession, and suggests that the hero’s actions, and in particular his reticence in asking questions about the procession, should be read in the context of medieval Welsh customs and legal tradition. The article concludes with an exploration of the implications of the proposed interpretation for the reading of Historia Peredur as a postcolonial narrative.
Knight Fever: Sickness, masculinity and narrative absence in the Mort Artu, Béroul’s Tristan and Thomas of Britain’s Tristan
Authors: Bateman Mary
Published: September 2021

The ideal knight protagonist of high medieval romance should be capable of engaging actively in chivalric activities, whether martial or amatory. What happens, then, when knight protagonists fall ill? Illness presents a problem: the knight loses his ability to act and is no longer in control of his own body. This article examines the fates of knights who fall ill in three Arthurian romances of the twelfth and thirteenth centuries: the Mort Artu, Thomas of Britain’s Tristan and Béroul’s Tristan. Illness has a marked effect on the presence of knights, both narratologically and to other characters in the text. When knights fall ill, they are temporarily excised from the narrative until their ability to be active is restored. An exception to this illness-absence paradigm occurs when the heroes of romance feign illness: at such junctures, these men are still exemplifying the agency and resourcefulness required of an effective hero, and the narrative maintains its focus on them at these moments regardless of how other characters might be treating them.
Research on materials of solar selective absorption coating based on the first principle
Authors: Zhang Xuelin , Zhou Junjie , Fu Weidong , Chen Lei
Published: September 2021

Based on the first principle, this paper studies the optical properties of Ni, Mo, CoO, and Cr2O3 according to the Materials Studio software. It is found that the absorptivity of Ni is low, while Ni has low emissivity. Hence, it can be used to reduce emissivity. The absorption rate of CoO is very high. Therefore, Ni and CoO are very suitable to be composed to make a solar selective absorption coating with high absorptivity and low emissivity. The mass ratio of Ni and CoO has a greater impact on the optical properties of the composite material, so the absorption–emission ratios of the composite material Ni–CoO at different mass ratios are calculated. The absorption–emission ratio is the highest when the mass ratio is 1:1, and the performance is the best, which is in good agreement with the result of the experiment. And we hope that our method will provide some help for the study of solar selective absorption composite coatings.
“And it rushed in”: A new proposal for interpreting GJudas 57,24
Authors: Edsall Benjamin A.
Published: September 2021

The present argument proposes a new interpretation for GJudas 57,24, a famously difficult passage in which someone enters a luminous cloud. While scholarship is divided over whether the phrase ⲁϥϥⲱⲕ applies to Judas or Jesus, there is a previously overlooked third option that is syntactically close to hand: it is Judas’s star. This translation, further, fits with important themes in the Gospel of Judas, both theological and narratological.
Be Yourself and Behave Appropriately: Exploring Associations Between Incongruent Personality States and Positive Affect, Tiredness, and Cognitive Performance
Authors: Kritzler Sarah , Luhmann Maike
Published: September 2021

Personality traits describe how people typically think, feel, and behave. Personality states describe how people think, feel, and behave in a given moment. In their daily lives, people often behave the way they typically do (they enact trait-congruent personality states), but occasionally behave differently from how they typically do (trait-incongruent personality states). Several theories propose that such incongruent personality states should be associated with undesirable outcomes such as less positive affect or more tiredness, but the current state of evidence is inconclusive and mostly based on one personality dimension: extraversion. In this study, we contribute to filling important gaps in the literature by examining congruence of personality dimensions other than extraversion, considering characteristics of the situation, and modeling congruence with state-of-the-art response surface analyses. We aimed to manipulate state honesty-humility and state agreeableness as well as perceived adversity and deception of the situation in a prisoner’s dilemma paradigm. The manipulations mostly had the intended effects but they also had additional unspecific effects on other personality states and situation characteristics. The study thus emphasized the difficulty of manipulating personality states, situation characteristics, and trait–state and state–situation congruence. In pre-registered analyses of variance, response surface analyses, and specification curve analyses, we then examined how trait–state congruence and state–situation congruence were associated with positive affect, tiredness, and performance in a numerical Stroop task. Neither trait–state congruence nor state–situation congruence were associated with positive affect, tiredness, or cognitive performance. However, in light of this study’s limitations, more studies that are carefully designed, carefully operationalized, and well-powered are needed to examine trait–state and state–situation congruence. Because experimental research can advance the understanding of personality dynamics substantially, future research should additionally further aim to develop valid and reliable manipulations of personality states and situation characteristics.
A bioinformatics analysis of the contribution of m6A methylation to the occurrence of diabetes mellitus
Authors: Lei Lei , Bai Yi-Hua , Jiang Hong-Ying , He Ting , Li Meng , Wang Jia-Ping
Published: September 2021

N6-methyladenosine (m6A) methylation has been reported to play a role in type 2 diabetes (T2D). However, the key component of m6A methylation has not been well explored in T2D. This study investigates the biological role and the underlying mechanism of m6A methylation genes in T2D. The Gene Expression Omnibus (GEO) database combined with the m6A methylation and transcriptome data of T2D patients were used to identify m6A methylation differentially expressed genes (mMDEGs). Ingenuity pathway analysis (IPA) was used to predict T2D-related differentially expressed genes (DEGs). Gene ontology (GO) term enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to determine the biological functions of mMDEGs. Gene set enrichment analysis (GSEA) was performed to further confirm the functional enrichment of mMDEGs and determine candidate hub genes. The least absolute shrinkage and selection operator (LASSO) regression analysis was carried out to screen for the best predictors of T2D, and RT-PCR and Western blot were used to verify the expression of the predictors. A total of 194 overlapping mMDEGs were detected. GO, KEGG, and GSEA analysis showed that mMDEGs were enriched in T2D and insulin signaling pathways, where the insulin gene (INS), the type 2 membranal glycoprotein gene (MAFA), and hexokinase 2 (HK2) gene were found. The LASSO regression analysis of candidate hub genes showed that the INS gene could be invoked as a predictive hub gene for T2D. INS, MAFA,and HK2 genes participate in the T2D disease process, but INS can better predict the occurrence of T2D.
Plasma progesterone secretion during gestation of the captive short-beaked echidna
Authors: Dutton-Regester Kate , Keeley Tamara , Fenelon Jane C , Roser Alice , Meer Haley , Hill Andrew , Pyne Michael , Renfree Marilyn B , Johnston Stephen
Published: September 2021

This study describes the progesterone profile during pregnancy in sexually mature female captive short-beaked echidnas (Tachyglossus aculeatus aculeatus). Echidnas were monitored daily by video surveillance to confirm key reproductive behaviour. Plasma samples were collected and pouch morphology was assessed three times a week. The pouch of the female echidna only develops during gestation and it was possible to create a four-stage grading system using the most distinguishable characteristics of pouch development. Maximum pouch development was associated with declining progesterone concentrations, with the pouch closing in a drawstring-like manner at oviposition. Control of pouch development in pregnant echidnas is not yet clear but later pouch development is associated with a decrease in progesterone and pouch closure and may be under mechanical influences of the egg or young in the pouch. The length of pregnancy was 16.7 ± 0.2 days with a 15.1 ± 1.0 days luteal phase followed by an incubation period in the pouch. Eggs could be detected in utero at least 4 days before oviposition. Plasma progesterone peaked at 10.5 ± 0.9 ng/mL within 12 days of mating but then declined to basal levels within 1 day of oviposition and remained basal throughout egg incubation, confirming that progesterone is elevated throughout pregnancy and that gestation does not extend beyond the luteal phase. After the loss of an egg or pouch young, most females entered a second oestrous cycle and ovulated, suggesting echidnas are seasonally polyoestrous. The duration of the luteal phase in the echidna corresponds with that observed in other mammals.
Los ciclos hidrosociales del Socavón en la transición de las crisis del agua en Mercaderes, Colombia
Authors: Osorio-Henao Julia Andrea , Burbano-Benavides Diana Marcela , Arias-Hoyos Arnol
Published: September 2021

Este análisis examina los hilos comunes presentes en las crisis del agua vivenciadas por Mercaderes (municipio del departamento del Cauca, Colombia), que le atribuyen un índice mayor a 40% de escasez hídrica, tras 60 años de una acelerada dinámica de degradación y desertificación de tierras. También, argumenta la importancia de cuidar fuentes de agua disponible para el municipio, como el Parque Natural el Socavón, anteponiendo la gestión local de su restauración y conservación sobre los intereses macroeconómicos extractivos de la naturaleza. Mediante la perspectiva de ciclos hidrosociales, explora y representa los flujos o retrocesos del agua configurados por relaciones de poder, dominación y control, desde intereses sociales, culturales, económicos y políticos. Así, fundamenta una toma participativa de decisiones acertadas en torno a la gestión del agua, donde la disponibilidad no solo depende de criterios de calidad y cantidad, sino también de la estabilidad del ecosistema socionatural y de las condiciones de acceso de la población para abastecerse y cuidar de ella. Los resultados muestran que la implementación del modelo de modernización rural desde los años 50 ha sido el factor principal en tales crisis del agua. Inició con la Bonanza Maicera entre 1950 y 1980, propiciada por la apuesta agroexportadora de los planes estatales de desarrollo rural. Actualmente, se advierte la amenaza de la megaminería priorizada en los planes de gobierno que pretenden transgredir el marco legal vigente que salvaguarda y prioriza los intereses comunes y ambientales, a pesar de la esforzada resistencia social de la localidad.
Comparison of Treatments by Mercerization and Plasma Glow Discharge on Residues of the Amazon Chestnut Shell (Bertholletia Excelsa)
Authors: Zapata Londoño Ximena , Rosero Romo James Janderson , Estupiñan Duran Hugo Armando
Published: September 2021

The chestnut shell from the Amazon region shared between Colombia, Brazil, and Perú is an abundant residue of the walnut used for obtaining food and cosmetic products. This residue is not yet usable due to the lack of knowledge of its properties and the environmental impact generated by its treatment through methods such as mercerization. This work presents the results of the characterization of Amazon chestnut shell residues treated by two methods, mercerization with NaOH solution and intense plasma discharge (Glow Discharge Plasma), in a reactor with argon gas in a 0,3-bar vacuum and discharge conditions of 80 mA and 600 s. The microstructural, morphological, topographic, and nanomechanical changes of the chestnut residues without treatment and with the two proposed treatments were evaluated by means of the µRaman, scanning electron microscopy, and atomic force microscopy techniques. The results showed the effectiveness of the plasma method over the mercerization method at obtaining more crystalline cellulose structures due to the reduction of hemicellulose, lignin, and the aqueous phase of walnut shell waste.
Use of phenolic compounds from cocoa pod-husks (Theobroma cacao L.) as inhibitors of Salmonella spp. in fresh cheese produced in Manabí, Ecuador
Authors: Santacruz Stalin , Medrano Pablo
Published: September 2021

Cocoa pod-husk is a by-product of cocoa processing, underutilized despite its phenolic compounds that can be an alternative to preserve the microbiological quality of food. The aim of this work was to evaluate the in vitro inhibitory activity of phenolic compounds from the cocoa pod-husk against Salmonella  spp, which is commonly found in fresh cheese produced in Manabí, Ecuador; as well as the effect on the sensory characteristics of cheese after immersion in a solution of phenolic compounds. In vitro microbiological analyzes of the inhibitory activity of phenolic compounds, showed that the concentrations 1 and 1.5% had the highest zone of inhibition against Salmonella spp., with mean diameters of 10.67 and 11.8 mm, respectively. On the other hand, the growth curve of Salmonella spp. indicated that 2 h were required for complete inhibition of bacteria by phenolic compounds at concentrations of 1 and 1.5%. For the sensory analyzes of cheese treated with phenolic compounds, 56.3% of the panelists accredited the firmness and odor with “I like it”, while 37.5% of the panelists qualified the color of the cheese with “I neither like nor dislike”. Firmness and odor had higher values of acceptance than color. For 25 and 12.5% of the panelists, firmness and odor were rated as “I like it a lot”, respectively, and 56.3% of the panelists conferred the label of “I like it” to both attributes. Cheese color was the lowest rated attribute, given that 12.5% of the panelists chose “I like it a lot” and 25% for “I like it”.
Physical, physiological, physicochemical and nutritional characterization of pumpkin (Cucurbita maxima) in postharvest stage cultivated in Antioquia-Colombia
Authors: Márquez Cardozo Carlos Julio , Molina Hernández Daniela , Caballero Birina Luz , Ciro Velásquez Hector Jose , Restrepo Molina Diego Alonso , Correa Londoño Guillermo Antonio
Published: September 2021

Pumpkin (Cucurbita maxima), also called squash is a mass consumption fruit used in agroindustrial transformations to obtain new food products. This study aimed to evaluate the physical, physiological and physicochemical properties during a storage period of 42 days and the nutritional compounds of the freshly harvested fruit fractions. According to the CIEL*a*b* space, both the pulp and peel did not present significant changes in L* and a* values during the evaluated storage time; however, in the peel, a change in the b* values was evidenced. In addition, there was a decrease in the firmness of 10.8% in the fruit with peel and in the pulp, it was of 19.8% was observed, with a whole fruit weight loss of 2.33% and an average respiration rate of 6.9 mg CO2 kg-1h-1. According to physicochemical characteristics evaluated in the pulp, the values of pH, percentage of humidity, acidity, water activity and total soluble solids had no statistically significant changes occurred during the storage time. At the nutritional level, pumpkin is a good source of minerals, with a high concentration of potassium in all its fractions, and also has in total carotenoids (4.11±1.6 mg of β-carotene g-1 oven dry (o.d) in pulp and 6.24±2.7 mg of β-carotene g-1 (o.d) in peel). It was possible to conclude that the pumpkin has a low respiration rate, maintaining its physicochemical characteristics suitable for consumption throughout the evaluation period, presenting suitable conditions.
Design Thinking of Islamic Counseling Service Inspiration of Prophet’s Hadith
Authors: Firdaus Muhammad Riyyan
Published: September 2021

This study aims to discuss the inspiration of the hadith of the Prophet in the implementation of counseling. This research method is qualitative through literature and field studies with the hadith thinking design approach. The results and discussion of this study include counseling during the pandemic, the Prophet Saw. role models in counseling, and innovations in Islamic counseling services. This research concludes that the hadith of the Prophet. has inspirational messages in a creative counseling process on Islamic counseling services through media platforms that are widely used in the contemporary era.
Al-Ushul Al-Khamsah Mutazilah dalam Pandangan Kh. Mustain Syafiie (Studi Analisis di Pondok Pesantren Tebuireng Jombang)
Authors: Mighfaza Muhammad Helmi , Muhlas Muhlas
Published: September 2021

This study aims to examine Ushul al-Khamsah Mutazilah (at-Tauhid, al-'Adl, al-Wad wa al-waid, al-Manzilah Baina al-Manzilatain, Amr Maruf Nahy Munkar) in the view of the Tebuireng ulama who is from the Ashariyah. The research method used qualitative with the type of field research to obtain data and kalam science as an umbrella for theory and analysis. The results and discussion of this research include the Mutazilah theology, the concept of Ushul al-Khamsah Mutazilah and the views of the Tebuireng ulama, while the ulama of Terbuireng believes that the concept of Ushul al-Khamsah in Mutazilah theology is more applicable in life and looks more at the anthropocentric side. This research concludes that the Tebuireng ulama are more personally adapted to using theology in their social and religious life in the community, judging from which it brings benefits to themselves and society.
Etika Berhias Perspektif Tafsir Al-Munir: Sebuah Kajian Sosiologis
Authors: Firdaus Muhamad Yoga
Published: September 2021

This study aims to discuss the ethics of decorated with the Tafsir Al-Munir perspective. This research method is qualitative through literature study with a sociological approach. The results and discussion of this research include the understanding of ethics, the meaning of the Tafsir Al-Munir, and the ethics decorated with the perspective of Tafsir Al-Munir on sociological analysis. This research concludes that decorating is a necessity of human life that must be equipped with ethics. The ethics inherent in decorative activities can give rise to good views from the surrounding environment to create collective goodness in the sphere of social life. This study recommends that further research be carried out related to ethics and decoration based on other interpretive perspectives.
Aliran Rasionalisme dan Empirisme dalam Kerangka Ilmu Pengetahuan
Authors: Vera Susanti , Hambali R. Yuli A.
Published: September 2021

This study aims to discuss the flow of rationalism and empiricism within the framework of science. The research method used is a qualitative type through literature study. The result and discussion of this research is that there are fundamental differences between science and knowledge at the level of philosophy of science. Science and knowledge are produced by human absorption of everything that is guided by curiosity (curiosity) which is human nature. The knowledge that is owned is then tested for accuracy by fulfilling three basic aspects of science, namely ontology (the object of knowledge), epistemology (how to obtain knowledge), and axiology (the use value of science). This study concludes that epistemologically, there are two understandings about the source of knowledge, namely, rationalism and empiricism. Rationalism believes that reason is the main source of knowledge and emepiriism believes that only sensory experience brings true knowledge. Both of them have a big role in the development of science to reach a critical human civilization and are able to survive as a superior identity in this universe.
Constructive and technological substantiation of constructive solutions for mountain bridge structures
Authors: Magomedov Mukhtar , Ovchinnikov Igor
Published: September 2021

In this article structural concepts peculiarities of bridge structures for mountain conditions were analyzed. It is noted that the mountainous terrain is characterized not only by a complex broken rock but also by the course of earthquakes and their genetic varieties: landslides, avalanches, rockfalls, etc. It is also noted that the interaction of the plain bridge and the environment is one-sided, while mountainous bridges themselves are negatively influenced by the mountainous environment. The Republic of Dagestan territory is considered an example of mountainous terrain. The linking bridge structures problem to various mountainous terrain regions is investigated here.
The peculiarity of the mountain rivers and bridge crossings interaction is noted in this paper, as well as the influence of rivers on the constructive justification of the mountain bridges solutions. The possibility of using cascade systems for regulating the mountain rivers water regime for the rational bridge crossings design with several holes is considered. Various options for the bridge crossings placement relative to mountain rivers are given as well as described their peculiarities.
Current support parts and expansion joints are considered and analyzed from the mountain bridge use on structures suitability point of view. The necessity of using seismic-insulating expansion joints and their influence on the conditions of vehicles passing through the bridge structure during an earthquake is substantiated here. The problem of using road pavements on mountain bridge structures is noted, the most common road pavements designs are described and analyzed. The concepts of the «ideal» bridge and their applied significance in relation to mountainous terrain are presented.
The constructive and technological solutions considered within the framework of this article will improve the bridge structure’s efficiency in mountainous conditions.
Religiosity and mental health as aspects of comprehensiveness in care
Authors: Martins Dalila de Alcântara , Coêlho Prisca Dara Lunieres Pêgas , Becker Sandra Greice , Ferreira Alaidistania Aparecida , Oliveira Maria Luiza Carvalho de , Monteiro Leslie Bezerra
Published: September 2021

ABSTRACT Objective: to understand how religiosity can influence the health of individuals diagnosed with mental disorders, based on comprehensive care. Methods: this is an integrative literature review, with the inclusion of articles in Portuguese, English and Spanish, between 2010 and 2018. Results: the critical analysis and qualitative synthesis of the 24 selected studies were categorized into two subtopics: The influence of religiosity in promoting comprehensive mental health care; Mental health versus religiosity: influencing conditions for effective access to comprehensive care. Final considerations: a positive influence of religiosity was identified in the lives of individuals diagnosed with mental disorders; however, evidence shows that health teams do not feel comfortable and prepared to work with religiosity as an expression of spirituality. This being one of the dimensional aspects of health, it can be inferred, on the results, the existence of this gap in the comprehensive care approach.
Evaluation of the health level of the elderly: patient care team considerations
Authors: Monteiro Maria Clara Duarte , Martins Maria Manuela Ferreira Pereira da Silva , Schoeller Soraia Dornelles
Published: September 2021

ABSTRACT Objective: To understand the differences of physicians, nurses, and social workers in the evaluation of the health status of the elderly. Methods: A cross-sectional quantitative study, using descriptive statistics. Non-probabilistic sample, consisting of 291 participants from three professional categories: 71 (24.4%) physicians, 192 (66%) nurses, and 28 (9.6%) social workers. We used a questionnaire including the variables: sociodemographic characteristics and instruments used for evaluation. Results: Instruments with greater utility for the evaluation of the elderly: for physicians, Mini Mental State Examination; for nurses, Braden scale; and for social workers, genogram. In the physical examination, the data most collected by physicians and nurses are the vital signs; and by social workers, the condition for performing the Activities of Daily Living. Conclusions: The evaluation of the elderly is based on a diversity of instruments and is an area in which health and social professionals need to share information.
Organic fertilization and crop load in yield and quality of organic nectarines in Italy
Authors: Barreto Caroline Farias , Antunes Luis Eduardo Correa , Toselli Moreno , Baldi Elena , Sorrenti Giovambattista , Quartieri Maurizio
Published: September 2021

Abstract Organic fertilization in orchards aims at increasing soil fertility, at impacting plant productivity and environmental sustainability. This study aimed at verifying the effects of organic fertilization and fruit load on two nectarine cultivars with high and low fruit loads. The experiment was carried out in an orchard under organic management in Fratta Terme, Po valley, in northeastern Italy. Nectarine cultivars Big Top and Carene, implemented in 2017 and grafted onto GF677, were used. Three levels of compost (0, 20 and 40 t dw ha-1) were combined with two fruit loads (low and high) to set up a factorial experimental design with two factors and four randomized replicates. Compost was incorporated at 20 cm depth. The following parameters were evaluated: nitrate- and ammonium- N concentrations in soil at 20 - 40 cm depth, macro and micronutrients in leaves, tree yield, number of fruits, fruit mass and diameter, soluble solids and pulp firmness. The supply of compost enhanced nitrate-N release in soil. In both cultivars, macro- and micronutrient concentrations in leaves were not affected by organic fertilization or fruit load, except for iron, which increased as a consequence of the compost supply. Low crop load induced higher fruit size in both varieties, a fact that was observed after pit hardening. However, the organic fertilization rate did not influence tree yield, fruit mass and soluble solids.
Challenges and perspectives for exploiting donkey milk in the Brazilian Northeast
Authors: Messias Tayanna Bernardo Oliveira Nunes , Araújo Emmanuella de Oliveira Moura , Sant’Ana Amanda Marília da Silva , Lucena Jorge Eduardo Cavalcante , Pacheco Maria Teresa Bertoldo , Queiroga Rita de Cássia Ramos do Egypto , Weiblen Rudi , De Palo Pasquale
Published: September 2021

ABSTRACT: Known as an animal of multiple functions, the Equus asinus has always been used for various purposes, such as entertainment, horseback riding, means of transport, agricultural traction and dairy farming. Although, donkeys are associated with a vast heritage of social, cultural, economic and ecological importance, they have lost their importance in the activities of rural properties, both in the developed economies of European countries and in the Northeast region of Brazil. Specific studies of production systems aimed rational exploitation of the donkey species in Brazil do not exist. New perspectives for the use of donkey in the Brazilian semiarid region through the dairy industry has aroused scientific interest and the interest of investors. The donkey, allied to the low production costs and rusticity of the species, has the capacity to contribute to the economy with products of high biological value and therapeutic characteristics. Thus, this review provided a broad view of the donkey bred in the Northeast of Brazil, observing its characteristics and relevance for the region. The benefits of donkey milk and the need to promote the production and marketing of this milk in the dairy production chain will also be discussed.
Bioactive properties of Persea lingue Ness (Lauraceae) fruit and leaf extracts
Authors: Lillo A. , Carvajal-Caiconte F. , Vital W. , Silva Junior P. I. , Paredes-Gamero E. J. , Alvear M. , Miranda A.
Published: September 2021

Abstract Persea lingue Ness is a tree species that lives mainly in temperate forests of south-central Chile. Its leaves are used in ethnomedicine, the fruit is a drupe similar to that of the avocado and has not been studied. The aim of this study was to determine the cytotoxicity in leukemia cell and antibacterial activity, along with some chemical content characteristics of P. lingue fruit and leaf extracts. The antibacterial activity was determined by the inhibition of bacterial growth in liquid medium assay against Gram-positive and Gram-negative bacteria. The leukemia cell lines Kasumi-1 and Jurkat were used to evaluate the cytotoxic activity by using propidium iodide and AlamarBlue assays. Total phenolic, flavonoid, condensed tannin, alkaloid and lipid contents were evaluated in the fruit and in the leaf extracts. The antioxidant activity of both extracts were also elavaluated. Leaf extract presented the highest content of total phenols, condensed tannins and flavonoids, and also the highest antioxidant activity. While the fruit extract has a higher amount of lipids and alkaloids and the high antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus megaterium and Micrococcus luteus. The leaf extract only showed activity against M. luteus. Concerning the cytotoxic activity, only the fruit extract showed cytotoxicity against the cell lines Jurkat and Kasumi-1. P. lingue fruit extract is a potential source of biologically active molecules for the development of new drugs to be used in some types of leukemia, as well as antibacterial agent.
The role of nurses in the integration of care for people with chronic noncommunicable diseases
Authors: Sousa Solange Meira de , Bernardino Elizabeth , Peres Aida Maris , Martins Maria Manuela , Gonçalves Luciana Schleder , Lacerda Maria Ribeiro
Published: September 2021

ABSTRACT Objective: To describe the role of nurses in the integration of care for people with chronic noncommunicable diseases. Method: This was an integrated single-case study conducted with care coordinators and nurses, purposefully selected, with interviews, documentary analysis and computerized files as sources of evidence. Categorical analysis was used based on data organization using MAXQDA® software, version 2018. Results: Thirty-four professionals participated. Most of the professionals who held coordination positions were nurses. The categories clinical team integration and care integration and their subcategories increased understanding of the roles of nurses. Conclusion: The role of nurses in integrating care for people with chronic noncommunicable diseases was mainly focused on coordination of care, which occurred because of the different roles that they play and that give them autonomy to make decisions and place them in the front line to contribute to situations that required assertive attitudes, such as directing users within the care network.
Factors associated with nursing workload in three intensive care units
Authors: Rivera Diana Isabel Cáceres , Torres Claudia Consuelo , Romero Luis Alberto López
Published: September 2021

ABSTRACT Objective: To determine the nursing workload in intensive care units (ICUs) and the factors associated with the Nursing Activities Score (NAS). Method: An analytical cross-sectional study was carried out in three ICUs in Bucaramanga, Colombia, between February 2018 and February 2020. The nursing workload was estimated based on the NAS. A descriptive and bivariate analysis stratified by ICU was performed using a robust multiple linear regression model, and the factors associated with the nursing workload (p < 0.05) were estimated. Results: In this study, 362 records were included. The median NAS was 68.1 points (Q1:47.2–Q3:116.7). APACHE II (β = 3.13, CI: 95% 2.28; 3.98), days of stay in ICU ≥3 (β = 16.78, CI: 95% 6.15; 27.41), surgery provenance service (β = 22.31, CI: 95% 9.76; 34.86), and traumatology and emergencies diagnostic category (β = 33.72, CI 95%: 9.90; 57.53) were associated with high NAS scores. Conclusion: The nursing staff spend approximately 70% of their time on a single patient, and administrative work takes up most of their time. Hospital stays of longer than 3 days, high APACHE II score, coming from the surgery department, and having a diagnosis of trauma and emergency were associated with a high workload.
Leprosy patients quality of life: a scoping review
Authors: Barcelos Raissa Mariah Ferraz Moreira , Sousa Gutembergue Santos de , Almeida Michelle Veiga de , Palacio Fabiana Gulin Longhi , Gaíva Maria Aparecida Munhoz , Ferreira Silvana Margarida Benevides
Published: September 2021

ABSTRACT Objective: To explore the scientific evidence regarding the leprosy patients quality of life. Method: Scoping review according to the Joanna Briggs Institute methodology, with articles indexed in PubMed, Cochrane, LILACS, Embase, CINAHL, Scopus, Web of Science, PsyINFO, INFOLEP, and Google Scholar databases, published in full in Portuguese, English, or Spanish. Results: Seventy-four studies were identified, with 71 of quantitative approach and 3 with a mixed method. There was a predominance of studies published in Brazil (58.1%), with an adult population, (97.3%) and recruited in reference centers for the treatment of leprosy (52.7%). There was greater use of the WHOQOL-bref (50%) and SF-36 (18.9%) instruments to assess quality of life. The study showed that the greatest impairment in quality of life was related to the delay in the diagnosis of the disease, to leprosy reactions, physical disabilities, neuropathic pain, and stigma. Conclusion: Most studies were developed in endemic countries, with adults, and based on observational studies, and the worst scores obtained were associated with physical domain impairment.
DEVELOPMENT AND VALIDATION OF QUALITY OF LIFE SCALE FOR PEOPLE LIVING WITH HIV
Authors: Almeida-Cruz Maria Cristina Mendes de , Ávila Fernanda Maria Vieira Pereira , Castrighini Carolina Castro , Santos Claudia Benedita dos , Gir Elucir
Published: September 2021

ABSTRACT Objective: to develop and validate a scale to measure the quality of life of people living with HIV in Brazil. Method: methodological study conducted in a Brazilian care service specialized in sexually transmissible infections/AIDS between 2017 and 2019 addressing people living with HIV. The scale’s development and validation included exploratory factor analysis to describe its factor structure and psychometric properties, Multitrait-Multimethod analysis to verify its validity and Cronbach’s alpha for reliability. Floor and ceiling effects were described according to the responses’ frequency distribution. Results: a total of 460 people living with HIV participated. Most were men 276 (60.0%) aged 43 on average (SD=±12.4). The Exploratory Factor Analysis revealed four factors with 39.9% of explained variance. The total scale presented satisfactory reliability with a Cronbach’s alpha equal to 85.0%. Most items presented satisfactory convergent and divergent validity. The presence of floor and ceiling effects were found. The scale’s final version was composed of 45 items. Conclusion: the Quali-HIV Scale is a valid and reliable tool to measure the quality of life of people living with HIV.
SIZING OF NURSING STAFF IN CLINICAL, SURGICAL AND PEDIATRIC HOSPITALIZATION UNITS
Authors: Moraes Rúbia Marcela Rodrigues , Nishiyama Juliana Aparecida Peixoto , Báo Ana Cristina Pretto , Costa Francine Melo da , Aldabe Lisiane Nunes , Oliveira João Lucas Campos de
Published: September 2021

ABSTRACT Objective: to size the Nursing staff in clinical, surgical and pediatric inpatient units. Method: a retrospective cross-sectional study, carried out in a university hospital in Midwest Brazil. The data were obtained from daily classifications of the care complexity level (n=5,808) among patients (n=882) hospitalized in the referred units, from July to October 2019, in addition to occupancy and hospital stay indicators. Descriptive statistical analysis, parameters and an equation specific to the design were used. Results: clinical hospitalization had the highest occupation, permanence, demand for Nursing hours/day (162.58) and deficit of nurses (-12), followed by the pediatric unit (-2). In the clinical and surgical units, there was the same available/real number of nurses. The general staff sized showed personnel surplus (+24), due to the high number of mid-level professionals in all the sectors. Conclusion: expected sizing inadequacy was verified, as there was a mismatch between workload and allocation of professionals in the units.
Modeling and simulation of heat and mass transfer during drying of coffee in a box dryer using C++ programming language
Authors: Rabello Gildeir Lima , Pimentel Uilla Fava , Aranda Donato , Poubel Willian
Published: September 2021

Abstract Drying is one of the stages of coffee processing and has been considered one of the factors that impact the quality of the final drink. In this sense, the present study developed a phenomenological model for a box-type dryer implementing in C / C ++ programming language. The profile of the exhaust air temperature was obtained over the drying time. The model was verified by comparing data obtained from the literature, thus guaranteeing its functionality to make predictions about the air temperature profile in equipment used by small coffee producers, which may contribute to the increase in product quality.
THE HYBRID RHETORICAL ETHOS
Authors: Mateus Samuel
Published: September 2021

Abstract There are three main schools for the study of the ethos: the pragmatic-discursive; the symbolic interactionist, and the rhetorical one. This paper aims to give an encompassing and fuller perspective on the rhetorical ethos that can be useful to the contemporary uses of the persuasive communication, including media communication such as advertising or marketing communication. Primarily, it outlines the conceptual employments ethos has suffered by through different subjects. Subsequently, it briefly enumerates the major rhetorical traditions; lastly, it postulates the rhetoric ethos as a hybrid notion that includes both a projected and an intended dimension. We hope this distinction allows us to better will envisage the persuasive communication further than the forum/agora and its several digital uses in the 21th century.
ETHOS EM INTERAÇÃO: O DEBATE POLÍTICO-ELEITORAL ENTRE EDUARDO PAES E WILSON WITZEL EM 2018
Authors: Costa Wagner Alexandre dos Santos
Published: September 2021

Resumo No debate de segundo turno das eleições de 2018, enfrentaram-se os candidatos Eduardo Paes (DEM) e Wilson Witzel (PSC). Tendo em vista que no debate político-eleitoral o interesse é triunfar sobre o adversário, a imagem de si, prévia ao discurso ou propriamente nele desenvolvida, muitas vezes determina o sucesso da adesão de um auditório e o consequente sucesso de um projeto de dizer empreendido com certa finalidade. A proposta de estudo é analisar a tensão decorrente do jogo de imagens projetadas no debate político-eleitoral/2018, dando enfoque às situações de luta discursiva da etapa de segundo turno das eleições ao cargo de Governador do Estado do Rio de Janeiro. Para tanto, alia os quadros teórico-metodológicos dos estudos do ethos em interação (KERBRAT-ORECCHIONI, 2016; CHANAY; KERBRAT-ORECCHIONI, 2007) e da análise semiolinguística do discurso político (CHARAUDEAU, 2016, 2011).
Acaricidal activity of essential oils of Cinnamomum zeylanicum and Eremanthus erythropappus, major compounds and cinnamyl acetate in Rhipicephalus microplus
Authors: Marchesini Paula , Oliveira Débora Ramos de , Gomes Geovany Amorim , Rodrigues Tigressa Helena Soares , Maturano Ralph , Fidelis Queli Cristina , Catunda Júnior Francisco Eduardo Aragão , Carvalho Mário Geraldo de , Bittencourt Vânia Rita Elias Pinheiro , Monteiro Caio Márcio Oliveira
Published: September 2021

Abstract This study aimed to chemically characterize the essential oils (EOs) of Cinnamomum zeylanicum (cinnamon) and Eremanthus erythropappus (candeia) and evaluate their acaricidal activity, together with that of their major compounds and cinnamyl acetate derivative, against Rhipicephalus microplus. Essential oil compounds were identified through gas chromatography. The larval packet test (LPT) at concentrations ranging from 0.31 to 10.0 mg/mL and the adult immersion test (AIT) at concentrations between 2.5 and 60.0 mg/mL were performed. (E)-cinnamaldehyde and α-bisabolol were the major compounds in cinnamon (86.93%) and candeia (78.41%) EOs, respectively. In the LPT, the EOs of cinnamon and candeia and the compounds (E)-cinnamaldehyde, α-bisabolol and cinnamyl acetate resulted in 100% mortality at concentrations of 2.5, 2.5, 5.0, 10.0 and 10.0 mg/mL respectively. In the AIT, percentage control values > 95% were observed for cinnamon and candeia EOs, (E)-cinnamaldehyde and α-bisabolol at the concentrations of 5.0, 60.0, 20.0, and 20.0 mg/mL, respectively, whereas cinnamyl acetate showed low activity. We conclude that EOs and their compounds showed high acaricidal activity, whereas the acetylated derivative of (E)-cinnamaldehyde presented less acaricidal activity on R. microplus engorged females.
Epidemiology of canine visceral leishmaniasis in a vulnerable region in Brazil
Authors: Silva Douglas Aparecido da , Bonatto Natália Camila Minucci , Venturin Gabriela Lovizutto , Melo Larissa Martins , Oliveira Paula Lima de , Costa Letícia Ramos , Bosculo Maria Rachel Melo , Barros Luiz Daniel de , Lima Valéria Marçal Felix de , Almeida Breno Fernando Martins de
Published: September 2021

Abstract Visceral leishmaniasis (VL) is a neglected and endemic zoonosis that occurs throughout Brazil; nevertheless, few studies have focused on the early detection of the disease. The municipality of Ourinhos is a non-receptive, silent and vulnerable area for VL, where the seroprevalence of this disease has so far not been investigated. The present study aimed to determine the seroprevalence of canine VL in Ourinhos-SP, and to identify the presence of risk factors. Blood samples were obtained from 604 dogs during a rabies vaccination campaign together with application of a socioeconomic questionnaire, environmental and animal characteristics and tutor's knowledge about the disease. The samples were subjected to indirect ELISA and new samples were collected from reactive and suspect animals, including whole blood and lymph node aspiration evaluated by parasitological method, complete blood count and PCR. No animal was diagnosed as positive based on the combination of direct and indirect tests and the tutors' answers indicated little knowledge about leishmaniasis, being often confused with other diseases transmitted by arthropods; hence, according to the proposed methods, the presence of canine leishmaniasis in the city of Ourinhos was not confirmed and health education campaigns about the disease should be carried out.
Physical 1g modelling of defective small-scale piled-raft systems founded in sand
Authors: Cunha Renato Pinto da , Cordeiro Ary Franck Baia , Sales Maurício Martines , Bernardes Heitor Cardoso
Published: September 2021

The need for understanding the interaction between the elements of a piled-raft foundation system becomes relevant when one of the piles collapses, presents a defect related to the installation procedure, or when it is sought to optimise the number of piles to meet the criteria of load capacity and admissible settlement. In the paper, 20 small-scale 1g load tests were performed in model piled-raft foundations placed within a cylindrical container. Pluviated sand under vertical loading was adopted to evaluate the cross-correlated qualitative behaviour of piled rafts with and without the presence of a single defective pile in systems of four, nine and 16 piles. The defects were simulated by the variation of the length of the pile, considering it shorter or absent, at distinct positions on the system – that is, corner, edge and centre of the raft locations. The results indicate that the position of the defective pile may be more detrimental to the foundation stiffness and load capacity than the level of damage of the pile, such as the cases evolving the presence of defective piles in the corner position.
Protein Utilization, Immune Function, and Hepatic Antioxidant Activity of Syrian Hamster Rats Fed Tahini in Combination with Other Oily Seeds
Authors: G Sumainah , L Laban
Published: September 2021

Background: Consumption of sesame seed products is increasing worldwide, and sesame may be suitable as a quality protein source for preschool children when combined with other sources of plant proteins.
Tea for Sport and Fitness: A Scoping Review
Authors: E Derbyshire , T Bond , G Jenkins
Published: September 2021

An extended evidence-base has evaluated the role of nutrition in sports and fitness. The roles of hydration are also well covered but within this the specific roles of tea are not yet discussed widely. Subsequently, the present scoping review aims to evaluate the potential roles of tea in relation to aspects of sports and fitness performance. Searches for human observational studies and clinical trials were undertaken in PubMed. gov, Science Direct and Google Scholar databases. Sixteen relevant publications were identified with five focusing on outcomes related to body weight, composition, adiposity, or fat oxidation. Other reported outcomes included strength, muscle strength, or mass, oxidative/antioxidant and hydration status, salivary antibacterial capacity, and balance performance. Evidence appeared strongest for green and matcha tea with the typical ingestion of 2 to 3 cups daily being associated with improved body composition, antioxidant profile, sleep quality (low caffeine green tea), salivary defence mechanisms against microbial pathogens and reduced adiposity. From a general stance tea drinking could be an alternative beverage choice for those keeping active, providing a source of fluids and polyphenols. Older populations, those undertaking activities in colder climates, or for prolonged durations e.g., long-distance walking may benefit from personalised hydration programmes that could involve tea drinking. Larger and longer randomised controlled trials using tea in beverage form rather than as extracts or supplements are now warranted to further advance science in this field.