bluuebunny/crossref_metadata_2025 huggingface dataset:
Forward Modeling Reveals Multidecadal Trends in Cambial Kinetics and Phenology at Treeline
Authors: Tumajer Jan , Kašpar Jakub , Kuželová Hana , Shishov Vladimir V. , Tychkov Ivan I. , Popkova Margarita I. , Vaganov Eugene A. , Treml Václav
Published: January 2021

Significant alterations of cambial activity might be expected due to climate warming, leading to growing season extension and higher growth rates especially in cold-limited forests. However, assessment of climate-change-driven trends in intra-annual wood formation suffers from the lack of direct observations with a timespan exceeding a few years. We used the Vaganov-Shashkin process-based model to: (i) simulate daily resolved numbers of cambial and differentiating cells; and (ii) develop chronologies of the onset and termination of specific phases of cambial phenology during 1961–2017. We also determined the dominant climatic factor limiting cambial activity for each day. To asses intra-annual model validity, we used 8 years of direct xylogenesis monitoring from the treeline region of the Krkonoše Mts. (Czechia). The model exhibits high validity in case of spring phenological phases and a seasonal dynamics of tracheid production, but its precision declines for estimates of autumn phenological phases and growing season duration. The simulations reveal an increasing trend in the number of tracheids produced by cambium each year by 0.42 cells/year. Spring phenological phases (onset of cambial cell growth and tracheid enlargement) show significant shifts toward earlier occurrence in the year (for 0.28–0.34 days/year). In addition, there is a significant increase in simulated growth rates during entire growing season associated with the intra-annual redistribution of the dominant climatic controls over cambial activity. Results suggest that higher growth rates at treeline are driven by (i) temperature-stimulated intensification of spring cambial kinetics, and (ii) decoupling of summer growth rates from the limiting effect of low summer temperature due to higher frequency of climatically optimal days. Our results highlight that the cambial kinetics stimulation by increasing spring and summer temperatures and shifting spring phenology determine the recent growth trends of treeline ecosystems. Redistribution of individual climatic factors controlling cambial activity during the growing season questions the temporal stability of climatic signal of cold forest chronologies under ongoing climate change.
High Light Intensity Applied Shortly Before Harvest Improves Lettuce Nutritional Quality and Extends the Shelf Life
Authors: Min Qianxixi , Marcelis Leo F. M. , Nicole Celine C. S. , Woltering Ernst J.
Published: January 2021

The effect of light intensity applied shortly before harvest on the nutritional quality, postharvest performance, and shelf life of loose-leaf lettuce (Lactuca sativaL. cv. Expertise RZ Salanova®) was investigated. Lettuce was grown either in a greenhouse with supplemental high-pressure sodium light (Experiment 1, EXP 1) or in a climate room under white LED light (Experiment 2, EXP 2). In both experiments full grown plants were transferred to a climate room for the End of Production (EoP) light treatments during the last week of cultivation. During EoP lighting plants were exposed to different intensities (0, 110, and 270 μmol m–2s–1in EXP 1; 50, 210, and 470 μmol m–2s–1in EXP 2) from white-red LEDs for 6 (EXP 2) or 7 days (EXP 1). Mature leaves were then harvested and stored in darkness at 10°C to study the postharvest performance. Changes in dry matter content, total ascorbic acid, and carbohydrates (including glucose, fructose sucrose, and starch) levels were determined during EoP lighting and during the subsequent shelf life as indicators of lettuce nutritional quality. Quality aspects (appearance, texture, and odor) were accessed during the shelf life as indicators of postharvest performance. In both experiments, high light intensities applied in EoP lighting increased dry matter percentage and contents of ascorbic acid (AsA) and carbohydrates at harvest and these increased levels were maintained during the shelf life. Increased light intensity in EoP treatment also extended the shelf life. The levels of AsA and carbohydrates at harvest correlated positively with the subsequent shelf life, indicating that the prolonged shelf life relies on the improved energy and antioxidant status of the crop at harvest.
No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam, a Putative Postmortem Meditation State
Authors: Lott Dylan T. , Yeshi Tenzin , Norchung N. , Dolma Sonam , Tsering Nyima , Jinpa Ngawang , Woser Tenzin , Dorjee Kunsang , Desel Tenzin , Fitch Dan , Finley Anna J. , Goldman Robin , Bernal Ana Maria Ortiz , Ragazzi Rachele , Aroor Karthik , Koger John , Francis Andy , Perlman David M. , Wielgosz Joseph , Bachhuber David R. W. , Tamdin Tsewang , Sadutshang Tsetan Dorji , Dunne John D. , Lutz Antoine , Davidson Richard J.
Published: January 2021

Recent EEG studies on the early postmortem interval that suggest the persistence of electrophysiological coherence and connectivity in the brain of animals and humans reinforce the need for further investigation of the relationship between the brain’s activity and the dying process. Neuroscience is now in a position to empirically evaluate the extended process of dying and, more specifically, to investigate the possibility of brain activity following the cessation of cardiac and respiratory function. Under the direction of the Center for Healthy Minds at the University of Wisconsin-Madison, research was conducted in India on a postmortem meditative state cultivated by some Tibetan Buddhist practitioners in which decomposition is putatively delayed. For all healthy baseline (HB) and postmortem (PM) subjects presented here, we collected resting state electroencephalographic data, mismatch negativity (MMN), and auditory brainstem response (ABR). In this study, we present HB data to demonstrate the feasibility of a sparse electrode EEG configuration to capture well-defined ERP waveforms from living subjects under very challenging field conditions. While living subjects displayed well-defined MMN and ABR responses, no recognizable EEG waveforms were discernable in any of the tukdam cases.
Why Psychology Needs to Stop Striving for Novelty and How to Move Towards Theory-Driven Research
Authors: Burghardt Juliane , Bodansky Alexander Neil
Published: January 2021

Psychological science is maturing and therefore transitioning from explorative to theory-driven research. While explorative research seeks to find something “new,” theory-driven research seeks to elaborate on already known and hence predictable effects. A consequence of these differences is that the quality of explorative and theory-driven research needs to be judged by distinct criterions that optimally support their respective development. Especially, theory-driven research needs to be judged by its methodological rigor. A focus on innovativeness, which is typical for explorative research, will instead incentivize bad research practices (e.g., imprecise theorizing, ignoring previous research, parallel theories). To support the advancement of psychology, we must drop the innovation requirement for theory-driven research and instead require the strongest methods, which are marked by high internal and external validity. Precise theorizing needs to substitute novelty. Theories are advanced by requiring explicit, testable assumptions, and an explicit preference for one theory over another. These explicit and potentially wrong assumptions should not be silenced within the peer-review process, but instead be scrutinized in new publications. Importantly, these changes in scientific conduct need to be supported by senior researchers, especially, in their roles as editors, reviewers, and in the hiring process. An important obstacle to further theory-driven research is to measure scientific merit using researchers’ number of publications, which favors theoretically shallow and imprecise writing. Additionally, it makes publications the central target of scientific misconduct even though they are the main source of information for the scientific community and the public. To advance the field, researchers should be judged by their contribution to the scientific community (e.g., exchange with and support of colleagues, and mentoring). Another step to advance psychology is to clearly differentiate between measurement model and theory, and not to overgeneralize based on few stimuli, incidences, or studies. We will use ideas from the theory of science to underline the changes necessary within the field of psychology to overcome this existential replication crisis.
The Developmental Process of Peer Support Networks: The Role of Friendship
Authors: Wang Lingfei , Liang Lichan , Liu Zhengguang , Yuan Keman , Ju Jiawen , Bian Yufang
Published: January 2021

This study investigated the characteristics and development of peer support networks in an effort to unravel the role of friendship in this developmental process. The relationships between friendship networks and peer support networks were explored, and the influence of dyadic and triadic friendships on the development of peer support relationships was examined. Two waves of data were collected among a sample of adolescents in six Chinese junior high schools (n= 913 students from 28 classrooms; mean age = 14.13 years; 50.49% boys), and classroom friendship networks and peer support networks were analyzed. The results showed that peer support networks were sparse, hierarchical, and sex-segregated. Furthermore, peer support networks and friendship networks partially overlapped. Friends tended to have similar support-seeking and support-providing ties. Longitudinal multiplex social network analysis revealed that peer support networks changed moderately over time, and friendships played various roles in the development of peer support networks. Dyadic friendships improved the formation of peer support ties. A mutual friend improved the formation of support relationships between two students when the mutual friend chose the two students as friends, but a mutual friend also hindered or had no effects on the formation of support relationships in other cases. The implications for educators to improve peer support networks are presented, and directions for future research are discussed.
Does Feedback Seeking Help Safety Performance Improvement? The Role of Consideration of Future Consequence
Authors: Zhang Tian-tian , Li Miao-miao
Published: January 2021

The purpose of this paper is to examine how feedback seeking impact safety performance through feedback environment and the moderating role of consideration of future consequence. Correlation data were collected from 202 participants in three industries of China. Results indicate that feedback seeking is positively associated with feedback environment and safety performance, the feedback environment mediated the relationship between feedback seeking and safety performance. However, the positive effect of feedback environment on safety performance is more significant when consideration of future consequence is high. Overall, the findings highlight the critical importance of individual features in the research on safety performance. The conclusion is conducive to a more detailed understanding of the antecedents that affect safety performance and provides a new perspective for the improvement of safety performance.
Factors Associated With Psychological Distress in Health-Care Workers During an Infectious Disease Outbreak: A Rapid Systematic Review of the Evidence
Authors: Sirois Fuschia M. , Owens Janine
Published: January 2021

Objective:Health-care workers (HCW) are at risk for psychological distress during an infectious disease outbreak, such as the coronavirus pandemic, due to the demands of dealing with a public health emergency. This rapid systematic review examined the factors associated with psychological distress among HCW during an outbreak.

Method:We systematically reviewed literature on the factors associated with psychological distress (demographic characteristics, occupational, social, psychological, and infection-related factors) in HCW during an outbreak (COVID-19, SARS, MERS, H1N1, H7N9, and Ebola). Four electronic databases were searched (2000 to 15 November 2020) for relevant peer-reviewed research according to a pre-registered protocol. A narrative synthesis was conducted to identify fixed, modifiable, and infection-related factors linked to distress and psychiatric morbidity.

Results:From the 4,621 records identified, 138 with data from 143,246 HCW in 139 studies were included. All but two studies were cross-sectional. The majority of the studies were conducted during COVID-19 (k= 107,N= 34,334) and SARS (k= 21,N= 18,096). Consistent evidence indicated that being female, a nurse, experiencing stigma, maladaptive coping, having contact or risk of contact with infected patients, and experiencing quarantine, were risk factors for psychological distress among HCW. Personal and organizational social support, perceiving control, positive work attitudes, sufficient information about the outbreak and proper protection, training, and resources, were associated with less psychological distress.

Conclusions:This review highlights the key factors to the identify HCW who are most at risk for psychological distress during an outbreak and modifying factors to reduce distress and improve resilience. Recommendations are that HCW at risk for increased distress receive early interventions and ongoing monitoring because there is evidence that HCW distress can persist for up to 3 years after an outbreak. Further research needs to track the associations of risk and resilience factors with distress over time and the extent to which certain factors are inter-related and contribute to sustained or transient distress.
Problematic Smartphone Use—Comparison of Students With and Without Problematic Smartphone Use in Light of Personality
Authors: Eichenberg Christiane , Schott Markus , Schroiff Athina
Published: January 2021

Background: As a device with multiple functions, a smartphone become more and more relevant in everyday life. However, this goes along with an increase in reports about smartphone addiction and its unwanted consequences. One of the most important variables in the etiopathogenesis of addictive smartphone use is personality.

Objective: This study aimed to investigate predictors of problematic smartphone use. Clinically relevant differences in personality, psychopathology, and social support between students with and without problematic smartphone use were investigated.

Method: All currently enrolled students at the Sigmund Freud University in Vienna (N = 1,836) were surveyed. Response rate was 27.07% (N = 497, age: M = 19.6, SD = 8.04). The Smartphone Addiction Scale (SPAS), the 10-Item Big Five Inventory (BFI-10), the Brief Symptom Inventory (BSI-18), and a questionnaire on social support (F-SozU-K-14) were used.

Results: A total of 75 students (15.1% of the total sample) showed problematic smartphone use. In terms of personality, respondents with problematic smartphone use showed significantly higher values for extraversion and neuroticism compared than non-addicted users. Students with problematic smartphone use showed significantly higher levels in terms of depression and anxiety. Contrary to expectations, individuals with problematic smartphone use showed significantly higher values for perceived social support than with individuals without problematic smartphone use.

Discussion: Therapy for problematic smartphone use should be carried out taking into account discussed, important etiological factors, such as personality.
Mental Distress and Its Contributing Factors Among Young People During the First Wave of COVID-19: A Belgian Survey Study
Authors: Rens Eva , Smith Pierre , Nicaise Pablo , Lorant Vincent , Van den Broeck Kris
Published: January 2021

Background: The outbreak of the COVID-19 pandemic in 2020 and its associated measures led to high levels of mental distress in the general population. Previous research indicated that young people are especially vulnerable for a wide range of mental health problems during the pandemic, but little is known about the mechanisms. This study examined mental distress and its contributing factors among young Belgian people.

Methods: An online survey was widely distributed in Belgium during the first wave of COVID-19 in March, and 16–25-year-olds were selected as a subsample. Mental distress was assessed using the 12-item General Health Questionnaire (GHQ-12), and a threshold of ≥4 was used to discriminate mental distress cases from non-cases. Bivariate and multivariable logistic regression analyses were performed to evaluate possible predictors of mental distress, including demographics, chronic condition, history of mental health problems, social support, exposure to COVID-19, and several changes in everyday activities.

Results: A total of 2,008 respondents were included, of which the majority was female (78.09%) and student (66.82%). The results indicate that about two thirds (65.49%) experienced mental distress. In the multivariable regression model, significant (p < 0.01) predictors of mental distress were female gender (OR = 1.78), low social support (OR = 2.17), loneliness (OR = 5.17), a small (OR = 1.63), or large (OR = 3.08) increase in social media use, a small (OR = 1.63) or large (OR = 2.17) decrease in going out for drinks or food, and a decrease in doing home activities (OR = 2.72).

Conclusion: Young people experience high levels of mental distress during the COVID-19 pandemic. Our findings indicate that mental distress was highest among women, those experiencing loneliness or low social support and those whose usual everyday life is most affected. The psychological needs of young people, such as the need for peer interaction, should be more recognized and supported.
Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol Dependence and Relapse: A Resting-Functional Magnetic Resonance Imaging Study
Authors: Yang Xia , Meng Ya-jing , Tao Yu-jie , Deng Ren-hao , Wang Hui-yao , Li Xiao-jing , Wei Wei , Hua Yu , Wang Qiang , Deng Wei , Zhao Lian-sheng , Ma Xiao-hong , Li Ming-li , Xu Jia-jun , Li Jing , Liu Yan-song , Tang Zhen , Du Xiang-dong , Coid Jeremy W. , Greenshaw Andrew J. , Li Tao , Guo Wan-jun
Published: January 2021

Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.

Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-fMRI). Using the NAc and mPFC as seeds, we calculated changes in FC between the seeds and other brain regions. Over a follow-up period of 6 months, patients were measured with the Alcohol Use Disorder Identification Test (AUDIT) scale to identify relapse outcomes (AUDIT ≥ 8).

Results: Thirty-five (52.24%) of the AD patients relapsed during the follow-up period. AD displayed lower FC of the left fusiform, bilateral temporal superior and right postcentral regions with the NAc and lower FC of the right temporal inferior, bilateral temporal superior, and left cingulate anterior regions with the mPFC compared to controls. Among these FC changes, lower FC between the NAc and left fusiform, lower FC between the mPFC and left cingulate anterior cortex, and smoking status were independently associated with AD. Subjects in relapse exhibited lower FC of the right cingulate anterior cortex with NAc and of the left calcarine sulcus with mPFC compared to non-relapsed subjects; both of these reductions in FC independently predicted relapse. Additionally, FC between the mPFC and right frontal superior gyrus, as well as years of education, independently predicted relapse severity.

Conclusion: This study found that values of FC between selected seeds (i.e., the NAc and the mPFC) and some other reward- and/or impulse-control-related brain regions were associated with AD and relapse; these FC values could be potential biomarkers of AD or for prediction of relapse. These findings may help to guide further research on the neurobiology of AD and other addictive disorders.
First Person Account COVID 19 Delirium in a Doctor: When Death Stalks the Mind
Authors: Arumi Antonio , Bulbena-Cabre Andrea , Bulbena Antonio
Published: January 2021

Previous studies reported that 20–30% of COVID-19 patients will develop delirium during the hospitalization, achieving 70% in cases of severe illness. The risks factors and the consequences of delirium are well-documented in the literature; however, little is known about the personal experience of delirium. Delirium burden is common and tends to be distressing even after the delirium episode has resolved. Taking this in mind, the present work provides a first-person account of a doctor who acquired Covid-19 and developed bilateral pneumonia and had delirium and a complicate course of illness. During the course of his delirium, the patient recalled experiences of reality and unreality, complete disorientation, lack of control, strong emotions, and intense fear of dying which was significantly distressing. We anticipate that delirium burden will be common on these patients and family members and clinicians should be aware of this phenomenon in order to evaluate the neuropsychiatric consequences of this condition.
Impulsivity Mediates Associations Between Problematic Internet Use, Anxiety, and Depressive Symptoms in Students: A Cross-Sectional COVID-19 Study
Authors: Gecaite-Stonciene Julija , Saudargiene Ausra , Pranckeviciene Aiste , Liaugaudaite Vilma , Griskova-Bulanova Inga , Simkute Dovile , Naginiene Rima , Dainauskas Laurynas Linas , Ceidaite Gintare , Burkauskas Julius
Published: January 2021

Background:Problematic internet use (PIU) is a serious global mental health issue that especially manifested during the Coronavirus disease (COVID-19) pandemic. Engagement in PIU as an impulsive coping with mental distress may pose a long-lasting threat to develop anxiety and depressive disorders. The first aim of our study was to investigate the prevalence of PIU and mental distress symptoms during the COVID-19 pandemic among university students in Lithuania. The second aim was to test the hypothesis that PIU affects anxiety and depressive symptoms through the mediating role of impulsivity.

Methods:The cross-sectional study was comprised of 619 university students (92.9% females and 7.1% males) with a mean age of 22 ± 3 years who participated in an online survey from May to November, 2020. Participants completed the following scales: the Problematic Internet Use Questionnaire-9, the Generalized Anxiety Disorder Questionnaire-7, the Patient Health Questionnaire-9, and the Barratt Impulsiveness Scale-11. K-means cluster analysis and one-way multivariate analysis of variance were used for group comparison in terms of internet use time and habit change during COVID-19 pandemic. Structural equation modeling was applied to examine the mediating effect of impulsivity in association between PIU and mental distress, while controlling for age.

Results:In sum, 45.1% of the participants reported PIU and 38.1% had markedly expressed symptoms of anxiety while 43.6% of the students reported moderate to severe depressive symptoms. During the COVID-19 pandemic 76% of the students reported at least moderate increase in their internet use time. Anxiety and depressive symptoms were significantly higher in the group of frequent internet users. The results of the structural equational modeling analysis showed a statistically significant effect of PIU on subjective anxiety symptoms and the statistically significant effect of PIU on subjective depression symptoms, both mediated via impulsivity.

Conclusions:During COVID-19 pandemic, PIU, anxiety and depression symptoms are highly prevalent among students. Findings also suggest that relationships between PIU, anxiety and depressive symptoms are mediated via impulsivity. These results underscore the importance of the inclusion of impulsivity factor in the studies analyzing longitudinal effects of PIU on mental distress during COVID-19 pandemic.
Potential Impact of the Nonessential Energy-Dense Foods Tax on the Prevalence of Overweight and Obesity in Children: A Modeling Study
Authors: Illescas-Zárate Daniel , Batis Carolina , Ramírez-Silva Ivonne , Torres-Álvarez Rossana , Rivera Juan A. , Barrientos-Gutiérrez Tonatiuh
Published: January 2021

Background: Consumption of foods high in energy, sugar, fat, and salt contributes to the increase in body mass index and the prevalence of overweight and obesity in children. Mexico implemented an 8% tax to non-essential energy-dense foods (NEDF) in 2014 as part of a national strategy to reduce obesity.

Objective: We modeled the potential effect of the NEDF tax on body mass index and overweight and obesity in Mexican children (6–17 years).

Materials and Methods: We used the Dynamic Childhood Growth and Obesity Model calibrated to Mexican children to simulate the potential 1-year effect of the NEDF tax on body weight. Inputs for the model included NEDF consumption, weight, and height, obtained from the 2012 Mexican National Health and Nutrition Survey. To project the potential impact of the tax, we ran a first simulation without intervention and another reducing the caloric intake from NEDF in the proportion observed in the Mexican population after the tax (−5.1%). The tax effect was defined as the absolute difference in body mass index and prevalence of overweight and obesity between both models.

Results: The tax on NEDF should lead to a mean reduction of 4.1 g or 17.4 kcal/day of NEDF at the population level. One year after the tax, mean body weight and body mass index should decrease 0.40 kg and 0.19 kg/m2; this translates into −1.7 and −0.4% points in overweight and obesity, respectively.

Conclusions: The use of fiscal instruments to discourage the consumption of NEDF could help to reduce the prevalence of overweight and obesity in children.
Soil Moisture and Air Humidity Dependence of the Above-Ground Cosmic-Ray Neutron Intensity
Authors: Köhli Markus , Weimar Jannis , Schrön Martin , Baatz Roland , Schmidt Ulrich
Published: January 2021

Investigations of neutron transport through air and soil by Monte Carlo simulations led to major advancements toward a precise interpretation of measurements; they particularly improved the understanding of the cosmic-ray neutron footprint. Up to now, the conversion of soil moisture to a detectable neutron count rate has relied mainly on the equation presented by Desilets and Zreda in 2010. While in general a hyperbolic expression can be derived from theoretical considerations, their empiric parameterization needs to be revised for two reasons. Firstly, a rigorous mathematical treatment reveals that the values of the four parameters are ambiguous because their values are not independent. We found a three-parameter equation with unambiguous values of the parameters that is equivalent in any other respect to the four-parameter equation. Secondly, high-resolution Monte-Carlo simulations revealed a systematic deviation of the count rate to soil moisture relation especially for extremely dry conditions as well as very humid conditions. That is a hint that a smaller contribution to the intensity was forgotten or not adequately treated by the conventional approach. Investigating the above-ground neutron flux through a broadly based Monte-Carlo simulation campaign revealed a more detailed understanding of different contributions to this signal, especially targeting air humidity corrections. The packages MCNP and URANOS were used to derive a function able to describe the respective dependencies, including the effect of different hydrogen pools and the detector-specific response function. The new relationship has been tested at two exemplary measurement sites, and its remarkable performance allows for a promising prospect of more comprehensive data quality in the future.
Addressing Complex Challenges in Coupled Natural and Human Systems Through Principled Pragmatism: A Case Study From Bangladesh
Authors: Smith Kevin M. , Palash Wahid , Choudhury Enamul , Islam Shafiqul
Published: January 2021

Some of the most persistent challenges facing society and the environment arise from an intricate coupling of natural and human systems (CNHS). These challenges resist traditional expert-driven problem-solving approaches and require a careful synthesis of both “explanation” and “understanding” to achieve equity and sustainability. Whereas, explanations tend to be the domain of scientific experts who seek generalizable solutions through theory building, modeling, and testing, understandings represent the wisdom of practitioners that enables real-world problem solving to proceed by accounting for contextual values, capacities, and constraints. Using a case study from Bangladesh as an illustrative case of CNHS, we take an explanatory approach in using the extended case study method to show why and how an expert-led response to remediation of arsenic-contaminated wells led to unintended outcomes, which could have been accounted for if a complexity science informed framework of the problem was in place. The complexity frame keeps one alert to emergent patterns that otherwise remain unanticipated, and thereby, form the basis of adaptive actions. For a path forward in addressing complex CNHS problems, we introduce a novel problem-solving approach that combines pragmatic explanations and interpretive understandings with attention to emergent patterns. We argue that this problem-solving approach – which we term principled pragmatism – can effectively synthesize and apply scientific knowledge and local practical knowledge to develop and implement adaptive, actionable, and sustainable interventions.
An Alternative Site for Pin Placement in External Fixation of Pelvic Fractures: Lateral Posterior Pelvic External Fixator Surgical Technique
Authors: Russ Matthias K. , Navarre Pierre , Stevens Jarrad P.
Published: January 2021

Introduction: The application of an external fixator for unstable pelvic fractures is an important component of many resuscitation protocols. Moreover, certain pelvic fractures may be treated with an external fixator without requiring further internal fixation. We report our initial clinical results with an alternate pelvic external fixator site, the lateral posterior external fixator (LPEF), and describe the surgical technique.

Methods and Materials: From 2010 to 2013, we identified 27 consecutive patients (mean age 44.6 years, range 18–80 years) treated by the same surgeon (MKR) with an LPEF in a level 1 trauma center. Retrospective data collection included mechanism of injury, surgical interventions, and complications.

Results: The LPEF was used in 16 patients as acute pelvic stabilization and converted at a median of 2 days (interquartile range 1–3.5) to internal fixation, whereas in 10 patients, it was used as definitive treatment and removed at a median of 48 days (interquartile range 37–64). One patient died on day 14, secondary to his severe closed head injury. The only surgical complications were two wound infections (20%, 2/10 in the group of definitive LPEFs), which resolved without sequelae after the removal of the LPEF (at 36 and 50 days) and antibiotics, one case of loss of fixation leading to the removal of the LPEF at 71 days, and one patient who had hypergranulating external fixator sites and eventually healed without any cutaneous sequelae. All fractures consolidated in a good position.

Discussion: The described techniques of pelvic external fixation include the anterosuperior (iliac wing), supra-acetabular (anteroinferior), and subcristal (anterior superior iliac spine) insertion sites. The reported infection rates in definitive pelvic fracture treatment range from 20 to 40%. Due to the localization of the insertion sites, the lateral femoral cutaneous nerve is potentially at risk with the last two techniques. On the other hand, the LPEF insertion site is quite safe, as it is anatomically far from any nerves and the inguinal region, and allows easy access for laparotomy. The results in this series suggest that the lateral posterior pelvic external fixator technique is an alternative to previous techniques with a low risk of complications.
Fluid Therapy During Cardiopulmonary Resuscitation
Authors: Fletcher Daniel J. , Boller Manuel
Published: January 2021

Cardiopulmonary arrest (CPA), the acute cessation of blood flow and ventilation, is fatal if left untreated. Cardiopulmonary resuscitation (CPR) is targeted at restoring oxygen delivery to tissues to mitigate ischemic injury and to provide energy substrate to the tissues in order to achieve return of spontaneous circulation (ROSC). In addition to basic life support (BLS), targeted at replacing the mechanical aspects of circulation and ventilation, adjunctive advanced life support (ALS) interventions, such as intravenous fluid therapy, can improve the likelihood of ROSC depending on the specific characteristics of the patient. In hypovolemic patients with CPA, intravenous fluid boluses to improve preload and cardiac output are likely beneficial, and the use of hypertonic saline may confer additional neuroprotective effects. However, in euvolemic patients, isotonic or hypertonic crystalloid boluses may be detrimental due to decreased tissue blood flow caused by compromised tissue perfusion pressures. Synthetic colloids have not been shown to be beneficial in patients in CPA, and given their documented potential for harm, they are not recommended. Patients with documented electrolyte abnormalities such as hypokalemia or hyperkalemia benefit from therapy targeted at those disturbances, and patients with CPA induced by lipid soluble toxins may benefit from intravenous lipid emulsion therapy. Patients with prolonged CPA that have developed significant acidemia may benefit from intravenous buffer therapy, but patients with acute CPA may be harmed by buffers. In general, ALS fluid therapies should be used only if specific indications are present in the individual patient.
Analysis of Hair Cortisol as an Indicator of Chronic Stress in Pigs in Two Different Farrowing Systems
Authors: Wiechers Dierck-Hinrich , Brunner Susanne , Herbrandt Swetlana , Kemper Nicole , Fels Michaela
Published: January 2021

Confinement to farrowing crates is known to prevent sows from performing natural behavior, impairing animal welfare and possibly causing chronic stress. Hair cortisol analyses are increasingly used to detect chronic stress in animals. In the present study, hair samples were collected in the neck of sows kept either in farrowing crates (FC,n= 31) or in a loose-housing system (LH,n= 30) in six batches. Cortisol was extracted and analyzed using chemiluminescence immunoassay. Mean hair cortisol concentrations (HCC) did not differ significantly between the systems (LH: 1.85 ± 0.82 pg/mg, FC: 2.13 ± 1.53 pg/mg,P= 0.631). HCC was also not affected by other factors, such as sows' parity, number of piglets, skin lesion score or sow's weight loss during the farrowing period. However, highly significant differences were found in hair growth rates between different regions within the 20 × 30 cm shaving area. While the hair in both lateral parts of the shaving area grew almost identically (left: 7.48 ± 3.52 mm, right: 7.44 ± 3.24 mm,P= 1.00), the hair grew more in the area above the spine (12.27 + 3.95 mm,P< 0.001). In both systems, the mean individual lesion score of sows declined from the beginning to the end of the housing period (P< 0.001). No difference was found between FC and LH sows at any time (P> 0.05). Since neither the amount of skin lesions nor HCC differed between LH and FC sows, it may be concluded that confining sows in farrowing crates did not affect chronic stress levels. However, results may be affected by a downregulation of the hypothalamic-pituitary-adrenal axis during long-term stress, resulting in lower cortisol levels over time. HCC in sows may also be influenced by a dominant stressor, such as farrowing or the presence of suckling piglets. Thus, for a comparison of different farrowing systems regarding chronic stress, the use of hair cortisol measurement seems to be limited. The present results revealed that differences in hair growth rate within the same body region exist. This important finding should be considered when collecting hair samples in pigs, since hair cortisol concentrations may vary depending on hair growth and length.
Morphological and Biochemical Characterization of Wild Hop (Humulus lupulus L.) Populations from Banja Luka Area (Bosnia and Herzegovina)
Authors: Kondić Danijela , Čerenak Andreja , Košir Iztok Jože , Ocvirk Miha , Krmpot Tanja , Đurić Gordana
Published: January 2021

This study aims to do a morphological and biochemical characterization of selected wild hop populations from the Banja Luka region, as plant material with potential value for introduction into plant selection. Female inflorescences (cones) from seven populations (DKH3, DKH5, DKH6, DKH8, DKH9, DKH10, and DKH11) were sampled in 2018 and 2019. Hop cones were collected in October 2018 and 2019 for morphological characterization, when 50 cones per population were analyzed, and also the cones were collected in mid-September in 2019 for biochemical characterization. Morphological parameters were carried out for: cone length (cm), number of nodes per cone spindle, cone density, and number of seeds per cone, all important agronomic characters in hop production. Also, 27 components of essential oil and 6 components of hop resins were analyzed. Statistical analysis of morphological characteristics was performed by factorial analysis of variance (year × population), and the significance of individual differences was determined by LSD test. The grouping of examined hop populations according to the manifested morphological characteristics was performed by cluster analysis. Statistical analysis for biochemical characteristics was performed by analysis of variance, and the significance of the differences was tested by Tukey’s statistical test. In order to determine similarities between different population multivariant statistical method Principal component analysis (PCA) was applied. According to morphological and biochemical analysis, DKH6 hop population is singled out as the most valuable for hop breeding.
Consequences and Mitigation Strategies of Abiotic Stresses in Wheat (Triticum aestivum L.) under the Changing Climate
Authors: Hossain Akbar , Skalicky Milan , Brestic Marian , Maitra Sagar , Ashraful Alam M. , Syed M. Abu , Hossain Jamil , Sarkar Sukamal , Saha Saikat , Bhadra Preetha , Shankar Tanmoy , Bhatt Rajan , Kumar Chaki Apurbo , EL Sabagh Ayman , Islam Tofazzal
Published: January 2021

Wheat is one of the world’s most commonly consumed cereal grains. During abiotic stresses, the physiological and biochemical alterations in the cells reduce growth and development of plants that ultimately decrease the yield of wheat. Therefore, novel approaches are needed for sustainable wheat production under the changing climate to ensure food and nutritional security of the ever-increasing population of the world. There are two ways to alleviate the adverse effects of abiotic stresses in sustainable wheat production. These are (i) development of abiotic stress tolerant wheat cultivars by molecular breeding, speed breeding, genetic engineering, and/or gene editing approaches such as clustered regularly interspaced short palindromic repeats (CRISPR)-Cas toolkit, and (ii) application of improved agronomic, nano-based agricultural technology, and other climate-smart agricultural technologies. The development of stress-tolerant wheat cultivars by mobilizing global biodiversity and using molecular breeding, speed breeding, genetic engineering, and/or gene editing approaches such as CRISPR-Cas toolkit is considered the most promising ways for sustainable wheat production in the changing climate in major wheat-growing regions of the world. This comprehensive review updates the adverse effects of major abiotic stresses and discusses the potentials of some novel approaches such as molecular breeding, biotechnology and genetic-engineering, speed breeding, nanotechnology, and improved agronomic practices for sustainable wheat production in the changing climate.
Stimulus Control of Odorant Concentration: Pilot Study of Generalization and Discrimination of Odor Concentration in Canines
Authors: DeChant Mallory T. , Bunker Paul C. , Hall Nathaniel J.
Published: January 2021

Despite dogs’ widespread use as detection systems, little is known about how dogs generalize to variations of an odorant’s concentration. Further, it is unclear whether dogs can be trained to discriminate between similar concentration variations of an odorant. Four dogs were trained to an odorant (0.01 air dilution of isoamyl acetate) in an air-dilution olfactometer, and we assessed spontaneous generalization to a range of concentrations lower than the training stimulus (Generalization Test 1). Dogs generalized to odors within a 10-fold range of the training odorant. Next, we conducted discrimination training to suppress responses to concentrations lower than a concentration dogs showed initial responding towards in Generalization Test 1 (0.0025 air dilution). Dogs successfully discriminated between 0.0025 and 0.01, exceeding 90% accuracy. However, when a second generalization test was conducted (Generalization Test 2), responding at the 0.0025 concentration immediately recovered and was no different than in Generalization Test 1. Dogs were then tested in another generalization test (Compound Discrimination and Generalization) in which generalization probes were embedded within discrimination trials, and dogs showed suppression of responding to the 0.0025 concentration and lower concentrations in this preparation. These data suggest dogs show limited spontaneous generalization across odor concentration and that dogs can be trained to discriminate between similar concentrations of the same odorant. Stimulus control, however, may depend on the negative stimulus, suggesting olfactory concentration generalization may depend on relative stimulus control. These results highlight the importance of considering odor concentration as a dimension for generalization in canine olfactory research.
Moral Convictions and Meat Consumption—A Comparative Study of the Animal Ethics Orientations of Consumers of Pork in Denmark, Germany, and Sweden
Authors: Lund Thomas B. , Denver Sigrid , Nordström Jonas , Christensen Tove , Sandøe Peter
Published: January 2021

Background: The relationship between animal ethics orientations and consumer demand for meat with high standards of animal welfare, and the way this relationship plays out in different countries, is not well understood. Using pork as a case study, this comparative study aims to identify the animal ethics orientations that drive purchases of welfare meat in Denmark, Germany, and Sweden. Methods: Cross-sectional questionnaire data from representative samples of approximately 1600 consumers in each country were collected. A segmentation of pork consumers (using latent profile analysis) was carried out. Results: In all three countries, two subgroups were concerned about farm animal welfare: the first subgroup was driven by animal rights values; the second subgroup by animal protection values, where the main principle was that “it is all right to use animals as long as they are treated well”. Other consumer groups are less concerned about farm animal welfare and display little or no preference for welfare pork. Conclusions: In all three countries, dual demand for welfare pork exists. The findings of this study can be used, among others, to understand the marketability of enhanced welfare animal products and the potential for market-driven animal welfare improvements.
Effect of Stroking on Serotonin, Noradrenaline, and Cortisol Levels in the Blood of Right- and Left-Pawed Dogs
Authors: Karpiński Mirosław , Ognik Katarzyna , Garbiec Aleksandra , Czyżowski Piotr , Krauze Magdalena
Published: January 2021

It has been assumed that stroking relieves stress responses in dogs, and dogs with the activation of the left-brain hemisphere (right-pawed) may show better adaptation to stress conditions. The aim of the study was to determine whether the stroking stimulus induced changes in the level of selected neuroregulators in dogs’ blood and whether these changes depended on the sex and the predominance of the activity of one of the brain hemispheres. The study involved 40 dogs of various breeds and both sexes. The experimental animals were subjected to a behavioral tests (Kong test), and the levels of noradrenaline, serotonin, and cortisol were determined in their blood plasma. The results of the behavioral test revealed that most dogs exhibited increased activity of the left hemisphere. Furthermore, irrespective of the sex and paw preference, stroking the animal was found to alleviate the stress response, which was reflected in reduced cortisol levels and increased serotonin levels. It was found that the plasma noradrenaline, cortisol, and serotonin levels were lower in the female dogs than in the males. Additionally, the plasma noradrenaline and serotonin levels were higher in the right-pawed dogs than in the left-pawed dogs. The present results confirm the assumption that right-pawed dogs adapt to stressful conditions more readily.
A Virtual Prototype for Fast Design and Visualization of Gerotor Pumps
Authors: Pareja-Corcho Juan , Moreno Aitor , Simoes Bruno , Pedrera-Busselo Asier , San-Jose Ekain , Ruiz-Salguero Oscar , Posada Jorge
Published: January 2021

In the context of generation of lubrication flows, gear pumps are widely used, with gerotor-type pumps being specially popular, given their low cost, high compactness, and reliability. The design process of gerotor pumps requires the simulation of the fluid dynamics phenomena that characterize the fluid displacement by the pump. Designers and researchers mainly rely on these methods: (i) computational fluid dynamics (CFD) and (ii) lumped parameter models. CFD methods are accurate in predicting the behavior of the pump, at the expense of large computing resources and time. On the other hand, Lumped Parameter models are fast and they do not require CFD software, at the expense of diminished accuracy. Usually, Lumped Parameter fluid simulation is mounted on specialized black-box visual programming platforms. The resulting pressures and flow rates are then fed to the design software. In response to the current status, this manuscript reports a virtual prototype to be used in the context of a Digital Twin tool. Our approach: (1) integrates pump design, fast approximate simulation, and result visualization processes, (2) does not require an external numerical solver platforms for the approximate model, (3) allows for the fast simulation of gerotor performance using sensor data to feed the simulation model, and (4) compares simulated data vs. imported gerotor operational data. Our results show good agreement between our prediction and CFD-based simulations of the actual pump. Future work is required in predicting rotor micro-movements and cavitation effects, as well as further integration of the physical pump with the software tool.