bluuebunny/crossref_metadata_2025 huggingface dataset:
Conceptual foundations of the development of business social responsibility in Ukraine
Authors: Bondaruk Taisiya H. , Bondaruk Igor S.
Published: November 2021

Purpose of the research. The main purpose of the article is to deepen the theoretical foundations of business social responsibility formation and its development in Ukraine. Methodology. It was used the following methods: comparative economic analysis, induction and deduction, summarizing, logical generalization, grouping and graphic expression. Results. It is substantiated that the development of business, the integration of the Ukrainian economy into the world economic system poses new challenges to business, related to the intensification of processes in the field of social responsibility in Ukraine. It is substantiated that the management of social responsibility of business is realized through the influence of the state on the improvement of labor relations, the introduction of honest business practices, against-corruption practices, expanding environmental responsibility of business and its cooperation with local communities. It is determined that business social responsibility is gradually becoming an important component of strategic management of enterprises in Ukraine. It is proved that in modern conditions the partnership between the state and business (joint regulation) prevails, and also the development of self-regulation is intensified, which together are able to ensure their effectiveness in modern conditions. Practical meaning. Important trends in the development of business social responsibility in Ukraine are insufficient assessment of the importance of social responsibility, and compliance with only mandatory rules set by applicable law. Prospects for further research. The formation of theoretical foundations of business social responsibility and its development in Ukraine confirms the need for further scientific substantiation of toolkit for assessing the effectiveness of social responsibility.
Assessing the quality of international trade and economic relations in the agricultural sector
Authors: Khvostikov Andrii
Published: November 2021

Purpose of the research. The main purpose of the article is to improve the methodical support for assessing the quality of international trade and economic relations in the agricultural sector. Methodology. In the course of the research, the following methods were applied: fuzzy logic inference, generalization, comparison, graphical, expert assessments, etc. Results. The role of international trade and economic relations in the development of the domestic economy has been substantiated. The expediency of using forecasting as a tool for assessing the prospects for expanding cooperation in the field of agriculture with other countries has been proved. The main indicators have been determined that are used in the process of measuring the relationships quality. The necessity of developing tools for assessing the quality of international trade and economic relations has been substantiated. It has been proposed to carry out an assessment using the fuzzy sets theory based on the formed thesaurus, which includes a fuzzy set, membership function, fuzzy variable, linguistic variable, fuzzy knowledge base, fuzzy logic inference. The scheme of the procedure for assessing the quality of international trade and economic relations using the method of fuzzy logic inference and description of the fuzzy system for assessing the quality of international trade and economic relations of the agricultural sector of Ukraine have been developed. An analysis has been carried out within the research framework of bilateral agreements between Ukraine and partners in the field of agriculture and it has been determined that an example of high-quality international trade and economic relations is cooperation with China, India, Germany, the United Arab Emirates; moderate – with Georgia, Poland, France, Korea; low – with Japan, Iran, Kazakhstan, etc. Practical meaning. Based on the results of the assessment, in accordance with the quality level of international trade and economic relations, priority areas of cooperation for Ukraine with partner countries to promote the development of its economy have been identified. Prospects for further research by the author are to develop a mechanism for increasing the quality of international trade and economic relations between Ukraine and partner countries.
FINANÇAS PESSOAIS
Authors: Barros Daniela Pinto , Ferreira Luciana Nunes , Soares Isabel Teresinha Dutra
Published: November 2021

Pesquisas recentes a respeito do comportamento financeiro dos brasileiros destacam o fato de aproximadamente 81% dos entrevistados saberem pouco ou nada de suas finanças e de 62,2% estarem endividados, independentemente da classe social a que pertencem. Por endividamento, compreende-se possuir parcelas a vencer de empréstimos, de financiamentos ou de compras realizadas em prestações. Nesse contexto, esse estudo, de natureza aplicada e abordagem quantitativa, teve o intuito de analisar a relação entre o perfil financeiro e a propensão ao endividamento dos professores da rede municipal de ensino do Capão do Leão (RS). Para alcançá-lo, foi aplicado um questionário estruturado com perguntas fechadas a 78 docentes, obtendo-se 75 respostas válidas. A partir dos resultados coletados, constatou-se que a maioria dos respondentes realiza algum tipo de planejamento das finanças pessoais, reconhecendo tal instrumento como uma ferramenta eficiente para uma gestão adequada dos seus proventos. Em relação à educação financeira, apesar de demonstrarem alguns saberes, carecem de instruções mais consistentes a fim de se tornarem multiplicadores. Também foi possível delinear dois perfis quanto ao relacionamento com o dinheiro e o endividamento: o construtor e o despreocupado.
Life without Milk
Authors: Latimore Janis
Published: November 2021

This op-ed article is a metaphor, bemoaning life without the cruelty, brutality, and murder of minorities by police. It indicates the similarities in not needing milk nor police when it is intolerant to survival. Milk is an important nutrient, staple, and a source of calcium for the purpose of supplementing the health in children’s development and for adults in need of additional, calcium-rich foods. Milk is known to build bone development and density. Milk has a long history in the “western diet” (Dalsgaard, Bertram 2015) (standard American diet), as an important nutrient, representative as a valuable source for the human body. In validating food “intake biomarkers (a measurable substance in an organism whose presence is indicative of some phenomenon, such as disease, infection, or environmental exposure), milk becomes part of the human biofluid (a generic term for bio-organic fluid produced by an organism such as, serum, plasma, urine, saliva, and so on” (Dalsgaard, Bertram 2015). We are taught by our parents and advised by natal-conscious doctors, that children cannot grow or maintain a healthy life as babies, pre-k, young adults or grown-ups, if we don’t drink milk or have a diet of milk by-products. But in 1972, early research found; “Negroes” (Paige, Bayless, Graham 1972), Asians, American Indians, Hispanic, South Americans and Black Heritage (American Family Physician, 2006), had trouble digesting an enzyme that breaks down the natural sugar in milk and the same intestinal intolerance arrives in significant numbers when this same group of people within the greater population are in the presence of police.
Effect of Stored Tiger Nut Oil Cultivars on the quality Properties of Fried Plantain Chips
Authors: A.F Ogori , G.C Nina , M Ukeyima
Published: November 2021

Studies on plantain chips fried with varietal stored tiger nut oil were studied. Three different tiger nut cultivars were sourced from Benue state and their oil extracted using hexane in an extractor. The stored oils were used to fry plantain chips after potatoes slicing and oil quality and stability analyzed. The moisture values of the chips from 0 week to week 12 for sample (A) ranged between 2.09-2.41 and 2.08-3.48 for samples (B) and (C) respectively .The thiobarbituric acid value from zero week - week12 for sample B O ranged between 0.19-0.21malon mg, sample BO ranged between 0.27-0.36 malon mg, while sample C ranged between 0.23-0.24malom mg. The appearance, aroma, taste, texture and overall acceptability of the chips ranged between 6.25-7.40, 6.20-6.55, 6.30-6.45, 6.20-6.55 and 6.15-6.55 respectively. Sample A and CKO (control) was most preferred in terms of appearance, aroma, taste, texture (crispness) and overall acceptability while sample A and C was least preferred. The sensory scores of the plantain chips fried with the oil were high for taste and aroma. During the storage, moisture values and thiobarbituric acid values of the chips were within the limits as recommended by CODEX Alimentarius.
CCNG1 oncogene: a novel biomarker for cancer therapy /gene therapy
Authors: M. Gordon Erlinda , R. Ravicz Joshua , P. Chawla Sant , W. Szeto Christopher , P. Chawla Sant , A. Morse Michael , L. Hall Frederick , M. Gordon Erlinda
Published: November 2021

Background: Metastatic cancer is associated with an invariably fatal outcome. However, DeltaRex-G, a tumor-targeted retrovector encoding a gene-edited dominant-negative CCNG1 inhibitor gene, has induced long term (>10 years) survival of patients with chemo-resistant metastatic pancreatic adenocarcinoma, malignant peripheral nerve sheath tumor, osteosarcoma, B-cell lymphoma, and breast carcinoma. Objective: To evaluate the level of CCNG1 expression in tumors as a potential biomarker for CCNG1 (Cyclin G1-blocking) inhibitor therapy. Methods: CCNG1 RNA expression levels that were previously measured as part of whole genome molecular profiling of tumors (TCGA, N=9161), adjacent “tissues” (TCGA, N=678) and GTEx normal tissues (N=7187) across 22 organ sites were analyzed. Differential expression of CCNG1 and Ki-67 in primary (N= 9161) vs metastatic (N= 393) tumors were also compared in primary (N=103) vs. metastatic (N=367) skin cancers (i.e., melanoma). Statistical Analysis: To detect systematically differential expression of CCNG1 and Ki-67 expression between populations (e.g. tumor vs. normal), unpaired Student's t-tests were performed. Results: Enhanced CCNG1 RNA and Cyclin G1 protein expression were noted in tumors compared to normal analogous counterparts, and CCNG1 expression correlated significantly with that of Ki-67. Moreover, CCNG1 expression tended to be higher than that of Ki-67 in metastatic vs primary tumors. Conclusions: Taken together with the emerging Cyclin G1 / Cdk / Myc / Mdm2 / p53 Axis governing Cancer Stem Cell Competence, this supportive data indicates: (1) CCNG1 expression is frequently enhanced in tumors when compared to their normal analogous counterparts, (2) CCNG1 and Ki-67 expressions are higher in metastatic vs primary tumors, (3) CCNG1 expression is significantly correlated with that of Ki-67, and (4) CCNG1 may actually be a stronger prognostic marker of stem cell competence, chemo-refractoriness, and EMT/metastasis than Ki-67. Phase 2 studies are planned to identify patients most likely to respond favorably to CCNG1 inhibitor therapy.
ETV6/RUNX1 fusion gene and its active role
Authors: Rahnemoon Ahmad Reza
Published: November 2021

Recent investigation successfully identified a pre leukemic ETV6/RUNX1-positive clone in the healthy twin of a patient diagnosed with ETV6/RUNXI-positive acute lymphoblastic leukemia (ALL) and also some studies with ETV6/RUNX1 knock in mice showed that the expression of the fusion gene is not sufficient for the invivo induction of ALL. Taken together, these data indicate that ETV6/RUNX1-positive leukemia is .generated through a multi-step mechanism, and that accumulation of additional genetic changes is necessary for the development of overt leukemia. Hence, to understand fully the genetic evolution of this disorder, identification of the complete spectrum of genetic changes that accompany the ETV6/RUNX1 fusion gene is necessary. Moreover, critical patho genetic insights may be gained from studying the correlation pattern of the different copy number changes.
The Strategic Clinical Model In Psychotherapy: Theoretical And Practical Profiles
Authors: Perrotta Giulio
Published: November 2021

This work deals with the analysis of the theoretical and practical profiles of the strategic clinical model in psychotherapy, starting from the examination of the historical and evolutionary contents of this particular model, passing through the main theories and techniques used in the clinic.
Confirmatory results about Spironolactone (S) Effects on AASI in Essential Hypertensive Patients: Short communication
Authors: Bendersky Mario
Published: November 2021

Background: In previous studies we demonstrated that spironolactone 50 mg OD, added in hypertensive patients who do not normalize pressure with enalapril 10 mg in the morning, after 3 months reduces pressure and reduces arterial stiffness.
Developing an Ethanol Utilization Pathway based NADH Regeneration System in Escherichia coli
Authors: Ng Wenfa
Published: November 2021

Interests remain in searching for cofactor regeneration system with higher efficiency at lower substrate cost. Glucose dehydrogenase (GDH) system has been dominant in NADH regeneration, but it only has a theoretical yield of one NADH per glucose molecule. This work sought to explore the utility of a two-step ethanol utilization pathway (EUP) in pathway-based NADH regeneration. The pathway runs from ethanol to acetaldehyde and to acetyl-CoA with each step generating one NADH, that together results in a higher theoretical yield of two NADH per ethanol molecule. In this project, anaerobic biotransformation of ketone (acetophenone or butanone) to alcohol by cpsADH from Candida parapsilosis was used as readout for evaluating relative efficacy and operating modes for EUP cofactor regeneration in Escherichia coli BL21 (DE3). Experiment tests validated that EUP was more efficient than GDH in NADH regeneration. Further, growing cell delivered higher biotransformation efficiency compared to resting cell due to the driving force generated by cell growth. Finally, preculture or cultivation in M9 + 10 g/L ethanol medium delivered higher biotransformation efficiency compared to LB medium. Overall, EUP could help regenerate NADH in support of a biocatalytic reaction, and is more efficient in cofactor regeneration than GDH.
Pain and discomfort in violation of bowel movements in children – an actual problem
Authors: Dmitrieva K , Vidiscak V , Prochotsky A , Furkova K , Kovacsova E , Stefanik P
Published: November 2021

Pain and discomfort during bowel movements in children are among the most common symptoms in the modern civilized world. The most common cause of these symptoms is chronic constipation, which is often treated by a pediatrician or pediatric gastroenterologist. In differen­tial diagnosis, it is very important to distinguish between chronic symptomatic constipation and functional (without an organic basis), which are most common in childhood. Organic causes of constipation are usually dealt with in cooperation with specialized specialists. The main patho­physiological mechanisms of functional constipation are stress, pain during emptying, and fear of further painful bowel movements. The clinical picture is dominated by in­frequent and difficult defecation of a large amount of hard stools. If the history, laboratory and other additional stud­ies indicate functional constipation, and there are no warn­ing signs of chronic symptomatic constipation, complex treatment can be started. Therapy includes psychological preparation of the patient and his family, working with the correct technique of defecation, dietary and regimen mea­sures, sufficient physical activity, the use of osmotic lax­atives. The presence of warning signs requires a rational differential diagnostic procedure, which varies depending on the age of the child.
Bilateral frontal intracranial xanthoma associated with type II hyperlipidemia in a 42-year-old woman: illustrative case
Authors: Argie Donny , Lauren Christopher , Malelak Elric B.
Published: November 2021

BACKGROUND

Xanthoma is a granulomatous lesion that develops from leakage of circulating serum lipoprotein into the surrounding tissue. An isolated intracranial xanthoma is rarely reported and usually misdiagnosed. Intracranial xanthoma is also rarely found in patients with hyperlipidemia. To the best of the authors’ knowledge, no previous studies and literature have reported bilateral involvement of intracranial xanthoma in the frontal lobe.

OBSERVATIONS

The authors reported an unusual case of bilateral involvement of intracranial xanthoma in the frontal lobe with associated type II hyperlipidemia in a 42-year-old woman. Macroscopically, the tumor had an appearance of greyish-yellow color with a brittle, solid consistency. Histopathological examination revealed numerous lipid-laden macrophages surrounded by a cystic, necrotic, partially hemorrhagic area, with some parts consisting of hemosiderophages and proliferative capillary blood vessels. The histopathological findings indicated the characteristics of xanthoma.

LESSONS

Bilateral frontal intracranial xanthoma with associated type II hyperlipidemia is an unusual finding. Despite its rarity and wide variety of radiological presentations, it should be considered one of the differential diagnoses of lesions that develop intracranially and intraaxially. Confirmation with histopathological examination is needed to exclude from other differential diagnoses.
Primary spinal melanoma: illustrative case
Authors: House Hanna , Archer Jacob , Bradbury Jamie
Published: November 2021

BACKGROUND

Primary spinal melanoma is extremely rare, accounting for ∼1% of all primary melanomas. Typically presenting insidiously in the thoracic spinal cord, primary spinal melanomas can have an acute presentation due to their propensity to hemorrhage.

OBSERVATIONS

Despite its rarity, primary spinal melanoma should be included in the differential diagnosis when a hemorrhagic pattern of T1 and T2 intensities is seen on magnetic resonance imaging. Furthermore, the complete diagnosis is crucial because the prognosis of a primary spinal melanoma is considerably more favorable than that of a primary cutaneous melanoma with metastatic spread.

LESSONS

Resection is the treatment of choice, with some authors advocating for postoperative chemotherapy, immunotherapy, and/or radiation. We describe a case of acute quadriplegia from hemorrhagic primary spinal melanoma requiring resection.
Acute thoracic disc heralded by change in spinal cord stimulation pattern: illustrative case
Authors: Behzadi Faraz , Telemi Edvin , Mansour Tarek R. , Zervos Thomas M. , Abdulhak Muwaffak M. , Air Ellen L.
Published: November 2021

BACKGROUND

Spinal cord stimulation (SCS) uses unique electric stimulation parameters to selectively treat specific regions of chronic or refractory back pain. Changing these parameters can lead to spreading paresthesia and/or pain beyond the desired region.

OBSERVATIONS

A patient with a history of stable, successful SCS treatment presented with acute development of paresthesias that were relieved by reduction of stimulation parameters. The patient required paradoxically lower SCS settings for control of chronic back pain. This presentation prompted further investigation, which revealed a new disc protrusion and cord compression at the level of the paddle lead.

LESSONS

In patients with SCS, a new onset of back pain accompanied by acute paresthesia that is reversible by reducing the SCS amplitude warrants investigation for new spine pathology.
Afrahat, Mowa XX: O trosce o biednych (Demonstratio XX: De sustentatione egenorum, PSyr 1, 893-930)
Authors: Uciecha Andrzej
Published: November 2021

Mowa O pomocy biednym jest dwudziestym wykładem w całej kolekcji Demonstrationes Afrahata. Mędrzec perski kontynuuje i dyskretnie rozwija polemikę z nauczaniem judaizmu i rabinów babilońskiej diaspory. Właściwe odczytanie przesłania zawartego w De sustentatione egenorum wymaga znajomości kontekstu społeczno-religijnego w jakim rozwijało się życie Kościoła w Persji w połowie IV wieku. Wykład może świadczyć o trudnej sytuacji chrześcijan babilońskich, którzy w czasie prześladowań Szapura II, nie rozumiejąc istotnych różnic między chrześcijaństwem a judaizmem, prawdopodobnie odwiedzali synagogi i korzystali z dobroczynności Żydów. Jak nauczyciel swoich uczniów Mędrzec Perski stara się zachęcić słuchaczy do podjęcia dzieła caritas christiana i umocnić tych chrześcijan, którzy już wspierają ubogich.
Efficacy of (R)-6-Adamantane-Derivatives of 1,3-Oxazinan-2-One and Piperidine-2,4-Dione in The Treatment of Mice Infected by the A/California/04/2009 influenza Virus
Authors: Glubokova Ekaterina A. , Leneva Irina A. , Kartashova Nadezda P. , Falynskova Irina N. , Tikhov Rabdan M. , Kuznetsov Nikolai Yu.
Published: November 2021

The World Health Organization (WHO) recommends antivirals as an additional line of defense against influenza. One of such drugs is rimantadine. However, most of the circulating strains of influenza A viruses are resistant to this drug. Thus, a search for analogs effective against rimantadine-resistant viruses is of the utmost importance. Here, we examined the efficiency of two adamantane azaheterocyclic rimantadine derivatives on a mouse model of pneumonia caused by the rimantadine-resistant influenza A virus /California/04/2009 (H1N1). BALB/c mice inoculated with the virus were treated with two doses (15 mg and 20 mg/kg a day) of tested analogs via oral administration for 5 days starting 4 hours before the infection. The efficacy was assessed by survival rate, mean day to death, weight loss, and viral titer in the lungs. Oral treatment with both compounds in both doses protected 60100% of the animals, significantly increased the survival rate, and abolished weight loss. The treatments also inhibited virus titer in the lungs in comparison to the control group. This treatment was more effective compared to rimantadine at the same scheme and dosage. Moreover, the study of the sensitivity of the virus isolated from the lungs of the treated mice and grown in MDCK cells showed that no resistance had emerged during the 5 days of treatment with both compounds.
Parkinson’s Disease Associated with GBA Gene Mutations: Molecular Aspects and Potential Treatment Approaches
Authors: Senkevich Konstantin A. , Kopytova Alena E. , Usenko Tatiana S. , Emelyanov Anton K. , Pchelina Sofya N.
Published: November 2021

Parkinsons disease (PD) is a multifactorial neurodegenerative disease. To date, genome-wide association studies have identified more than 70 loci associated with the risk of PD. Variants in the GBA gene encoding glucocerebrosidase are quite often found in PD patients in all populations across the world, which justifies intensive investigation of this gene. A number of biochemical features have been identified in patients with GBA-associated Parkinsons disease (GBA-PD). In particular, these include decreased activity of glucocerebrosidase and accumulation of the glucosylceramide substrate. These features were the basis for putting forward a hypothesis about treatment of GBA-PD using new strategies aimed at restoring glucocerebrosidase activity and reducing the substrate concentration. This paper discusses the molecular and genetic mechanisms of GBA-PD pathogenesis and potential approaches to the treatment of this form of the disease.
At the Crossroads: Mechanisms of Apoptosis and Autophagy in Cell Life and Death
Authors: Shliapina Viktoriia L. , Yurtaeva Sofia V. , Rubtsova Maria P. , Dontsova Olga A.
Published: November 2021

Apoptosis and autophagy are conserved processes that regulate cell survival and death under stress conditions. real rolex submariner vs fake
Apoptosis aims to remove cells from the body with minimal damage to surrounding tissues. Autophagy promotes removal of damaged organelles, protein aggregates, and cellular pathogens, stimulating cell survival. The signaling pathways involved in the regulation of apoptosis and autophagy largely overlap, leading to both competition and unidirectional interaction, which is of particular interest in investigating them as potential targets for cancer, paul newman rolex replica for saleautoimmune, and neurodegenerative disease therapies. This review analyzes the main pathways of molecular interactions between autophagy and apoptosis, which is necessary for understanding the mechanism maintaining rolex iced out fake the balance between cell death and survival under unfavorable conditions.
The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
Authors: Kuchur Oleg A. , Kuzmina Daria O. , Dukhinova Marina S. , Shtil Alexandr A.
Published: November 2021

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatments effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure.
The Role of Non-coding RNAs in the Pathogenesis of Glial Tumors
Authors: Kovalenko Tatyana F. , Larionova Tatyana D. , Antipova Nadezhda V. , Shakhparonov Michail I. , Pavlyukov Marat S.
Published: November 2021

Among the many malignant neoplasms, glioblastoma (GBM) leads to one of the worst prognosis for patients and has an almost 100% recurrence rate. The only chemotherapeutic drug that is widely used for treating glioblastoma is temozolomide, a DNA alkylating agent. Its impact, however, is only minor; it increases patients survival just by 12 to 14 months. Multiple highly selective compounds that affect specific proteins and have performed well in other types of cancer have proved ineffective against glioblastoma. Hence, there is an urgent need for novel methods that could help achieve the long-awaited progress in glioblastoma treatment. One of the potentially promising approaches is the targeting of non-coding RNAs (ncRNAs). These molecules are characterized by extremely high multifunctionality and often act as integrators by coordinating multiple key signaling pathways within the cell. Thus, the impact on ncRNAs has the potential to lead to a broader and stronger impact on cells, as opposed to the more focused action of inhibitors targeting specific proteins. In this review, we summarize the functions of long noncoding RNAs, circular RNAs, as well as microRNAs, PIWI-interacting RNAs, small nuclear and small nucleolar RNAs. We provide a classification of these transcripts and describe their role in various signaling pathways and physiological processes. We also provide examples of oncogenic and tumor suppressor ncRNAs belonging to each of these classes in the context of their involvement in the pathogenesis of gliomas and glioblastomas. In conclusion, we considered the potential use of ncRNAs as diagnostic markers and therapeutic targets for the treatment of glioblastoma.
Forces for Folding
Authors: Crane-Robinson Colyn
Published: November 2021

Understanding the nature of the forces driving the folding of proteins, nucleic acids and the formation of their complexes absolutely requires thermodynamic data, in addition to structural information. In practical terms, this means the use of super-sensitive scanning and titration calorimeters for experimental determination of the heats (enthalpies) characterising these processes. Peter Privalov was both an experimental thermodynamicist and a calorimeter designer/manufacturer who followed and propagated this credo. The sum total of his many publications, every one of which addresses a fundamental question, is his lasting epitaph.
A Monoiodotyrosine Challenge Test in a Parkinson’s Disease Model
Authors: Kim Alexander R. , Pavlova Ekaterina N. , Blokhin Viktor E. , Bogdanov Vsevolod V. , Ugrumov Michael V.
Published: November 2021

Early (preclinical) diagnosis of Parkinsons disease (PD) is a major challenge in modern neuroscience. The objective of this study was to experimentally evaluate a diagnostic challenge test with monoiodotyrosine (MIT), an endogenous inhibitor of tyrosine hydroxylase. Striatal dopamine was shown to decrease by 34% 2 h after subcutaneous injection of 100 mg/kg MIT to intact mice, with the effect not being amplified by a further increase in the MIT dose. The selected MIT dose caused motor impairment in a neurotoxic mouse model of preclinical PD, but not in the controls. This was because MIT reduced striatal dopamine to the threshold of motor symptoms manifestation only in PD mice. Therefore, using the experimental mouse model of preclinical PD, we have shown that a MIT challenge test may be used to detect latent nigrostriatal dysfunction.
Molecular Tools for Targeted Control of Nerve Cell Electrical Activity. Part I
Authors: Kolesov Danila V. , Sokolinskaya Elena L. , Lukyanov Konstantin A. , Bogdanov Alexey M.
Published: November 2021

In modern life sciences, the issue of a specific, exogenously directed manipulation of a cells biochemistry is a highly topical one. In the case of electrically excitable cells, the aim of the manipulation is to control the cells electrical activity, with the result being either excitation with subsequent generation of an action potential or inhibition and suppression of the excitatory currents. The techniques of electrical activity stimulation are of particular significance in tackling the most challenging basic problem: figuring out how the nervous system of higher multicellular organisms functions. At this juncture, when neuroscience is gradually abandoning the reductionist approach in favor of the direct investigation of complex neuronal systems, minimally invasive methods for brain tissue stimulation are becoming the basic element in the toolbox of those involved in the field. In this review, we describe three approaches that are based on the delivery of exogenous, genetically encoded molecules sensitive to external stimuli into the nervous tissue. These approaches include optogenetics (Part I) as well as chemogenetics and thermogenetics (Part II), which are significantly different not only in the nature of the stimuli and structure of the appropriate effector proteins, but also in the details of experimental applications. The latter circumstance is an indication that these are rather complementary than competing techniques.
ANALISIS RELAKSASI PERNAFASAN TERHADAP KECEMASAN PADA IBU HAMIL TRIMESTER III
Authors: Syahida Ayunin , Mirani Nanda
Published: November 2021

Background: During pregnancy, mothers experience physical and psychological changes that occur due to hormonal changes.The process of adjusting to new conditions experienced by pregnant women can then cause anxiety. To overcome anxiety during pregnancy, non-pharmacological options. Interventions that are often used and proven effective to reduce anxiety are breathing relaxation techniques.Purpose: This study aims to determine the analysis Breathing Relaxation on Anxiety in Pregnant Women in Trimester III in the Work in Puskesmas Langsa Baro.Methods: The designs used in this study were quasi-experimental designs with a one-group pre-test and post-test design approach. The number of research samples was 15 third trimester pregnant women, the sampling technique used was purposive sampling technique. Data analysis was carried out univariate and bivariate using the Paired T-Test.Results: The results showed that the level of anxiety was known to have a p value (sig) (0.000) < 0.05, which means that there is an effect of breathing relaxation on anxiety in  trimester III pregnant women.Conclusion: There is an effect of breathing relaxation on anxiety in trimester III pregnant women. It is hoped that health workers will increase counseling about pregnancy, especially about problems that can occur during pregnancy so that mothers can be more relaxed in dealing with pregnancy and childbirth.  Keywords: Breathing Relaxation, Anxiety, Pregnant ABSTRAKLatar Belakang: Selama kehamilan ibu mengalami perubahan fisik dan psikis yang terjadi akibat perubahan hormon. Proses penyesuaian diri terhadap keadaan baru yang dialami ibu hamil ini kemudian dapat menimbulkan kecemasan. Untuk mengatasi kecemasan pada saat hamil, pilihan non farmakologis. Intervensi yang sering di gunakan dan terbukti efektif untuk mengurangi kecemasan adalah teknik relaksasi pernafasan dan dzikir.Tujuan: Penelitian ini bertujuan untuk menganalisis Relaksasi Pernafasan Terhadap Kecemasan Pada Ibu Hamil Trimester III di Wilayah Kerja Puskesmas Langsa Baro Tahun 2021.Metode: Desain yang digunakan dalam penelitian ini adalah quasi eksperiment designs (eksperimen semu) dengan pendekatan one group pre test and post test design. Jumlah sampel penelitian sebanyak 15 ibu hamil trimester III. Teknik sampling yang digunakan teknik purposive sampling. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Paired T-Test.Hasil:Hasil penelitian didapatkan bahwa tingkat kecemasan diketahui nilai p (sig) (0,000) < 0,05 yang artinya terdapat pengaruh relaksasi pernafasan terhadap kecemasan pada ibu hamil trimester III.  Kesimpulan: Ada pengaruh kombinasi relaksasi pernafasan dan dzikir terhadap kecemasan pada ibu hamil trimester III. Diharapkan agar tenaga kesehatan lebih meningkatkan penyuluhan tentang kehamilan  terutama tentang masalah-masalah yang dapat terjadi pada masa kehamilan sehingga ibu dapat lebih santai dalam menghadapi masa kehamilan dan persalinan. Kata Kunci: Relaksasi Pernafasan, Kecemasan, Kehamilan
An osteopathic approach to occipital neuralgia and tinnitus
Authors: Aiman Alexis , Skaug Joy , Fleming Regina
Published: November 2021

Eye pain and ringing in the ear are non-specific symptoms commonly evaluated by primary care physicians and specialists alike. The differential diagnosis for these symptoms is broad and includes musculoskeletal, ophthalmologic and neurologic considerations. Careful consideration of the differential diagnosis should include acute, potentially life-threatening pathologies such as glaucoma or intracranial masses, as well as common pathologies, including cervicalgia, headache variants (migraine, tension) and acoustic neuroma.

This report describes a patient with eye pain caused by occipital neuralgia and tinnitus. Correcting the somatic dysfunctions found in the head, cervical, thoracic and rib regions with osteopathic manipulative treatment resolved the occipital neuralgia and the tinnitus for this patient. Thus, osteopathic manipulative treatment should be considered for conservative management of occipital neuralgia and tinnitus.
Improving diagnosis and treatment of benign paroxysmal positional vertigo
Authors: McIntire Larry , Martin Kindall , Motzkus Gregory , Shah Kunal , Malinowski Lauren , Paulson John
Published: November 2021

Background: Vertigo is defined as an illusion of motion caused by a mismatch of information between the visual, vestibular and somatosensory systems. The most common diagnosis associated with whirling vertigo is benign paroxysmal positional vertigo (BPPV), which affects approximately 3.4% of patients older than 60 years of age.

Objective: This paper aims to educate primary care providers on how to diagnose BPPV by performing canalith repositioning maneuvers at the initial point of care. Timely treatment of BPPV in the primary care office is believed to reduce healthcare costs by way of limiting unnecessary diagnostic testing and lowering referrals for specialty care. Immediate treatment is also believed to improve the quality of healthcare delivery for the vertigo patient by reducing morbidity and resolving the condition without the need for referrals or imaging.

Population Health: A review of the literature finds that delayed diagnosis and treatment of BPPV is associated with a host of deleterious effects on patients. Population health impacts include increasedrates of anxiety and depression; loss of work and/or change of career paths; inappropriate use of medications or emergency care resources; decreased access to healthcare services; increased healthcare costs; and reduced quality of care.

Diagnosis: A history of positional vertigo and evidence of nystagmus with Dix-Hallpike positioning confirms the diagnosis. A detailed description of the performance of this test is elucidated.

Treatment: The observed nystagmus is analyzed and classified based on directionality. Treatment can be initiated immediately with canalith repositioning maneuvers.
Los problemas de la gestión patrimonial en espacios traumáticos. La actuación sobre la memoria de la Guerra Civil en la provincia de Jaén
Authors: Chica Francisco Delgado
Published: November 2021

Actualmente nos enfrentamos a un turismo diferente que busca salir de los centros históricos y visitar lugares traumáticos de nuestra memoria más reciente con una fuerte carga emocional como Auschwitz o Chernóbil. En nuestro país sucede algo similar con determinados espacios donde acontecieron conflictos de la Guerra Civil. ¿A qué se debe este interés? Principalmente a la memoria histórica. Es por ello que en España y en Andalucía han entrado en vigor normativas con el objeto de salvaguardar la herencia y memoria del conflicto y de homenajear a sus víctimas. Situando como foco de atención la provincia de Jaén, lo que se pretende con esta breve contribución es cuestionar la gestión patrimonial de algunos bienes heredados del conflicto en la provincia de Jaén, así como poner en valor dos trincheras de la guerra conservadas en la localidad de Torredonjimeno.
Tecnologías para la detección de ocupación en edificios
Authors: Mora Dafni , De Simone Marilena , Chen Austin Miguel
Published: November 2021

Una importante parte del consumo de energía de los edificios está relacionado con el comportamiento de los ocupantes. Lo que significa que es necesario conocer con mayor precisión cómo se comporta y se mueve el usuario dentro de los ambientes, y este es uno de los retos que requiere conocer los tipos de tecnologías para la detección de la ocupación en edificios. En este artículo presentamos un resumen de las tecnologías utilizadas en la actualidad para el control de la ocupación en edificios, de manera de tener un marco de referencia y además poder indagar hacia donde se pueden dirigir las investigaciones futuras, tomando en cuenta el desarrollo actual.
Extrato de Corymbia citriodora sobre a germinação e crescimento de plântulas de rúcula cultivada (Eruca sativa L.)
Authors: Pelozato Paula Arriero , Faria Glaucia Amorim , Sachetim Matheus Augusto , Mantovani Fábia Eduarda , Furlani Junior Enes
Published: November 2021

Este trabalho tem como objetivo avaliar os possíveis efeitos alelopáticos do extrato aquoso de eucalipto (Corymbia citriodora) em diferentes concentrações (0, 25, 50, 75 e 100%) na germinação das sementes, crescimento inicial e no desenvolvimento de mudas de rúcula (Eruca sativa L.). Utilizou-se Delineamento Inteiramente Casualizado, com três repetições e cinco tratamentos compostos por doses crescentes (0, 25, 50, 75 e 100%) de extrato de eucalipto testados tanto em mudas, por aplicação foliar, quanto em sementes, por embebição. O extrato foi produzido pelo método frio de turbólise, com folhas de eucalipto trituradas com água em um liquidificador. Para as sementes de rúcula, foi avaliado o Índice de Velocidade de Germinação (IVG) e porcentagem de germinação até os 10 dias após semeadura (DAS) e altura de planta (AP) e número de folhas (NF), comprimento de raiz (CR), relação alométrica (RA). Para as mudas de rúcula, foram avaliadas as variáveis AP, NF, CR, RA, massa fresca da parte aérea (MFPA), massa fresca da raiz (MFRZ), massa seca da parte aérea (MSPA) e massa seca da raiz (MSRZ). A análise estatística dos dados foi realizada com o auxílio do aplicativo computacional SISVAR. Os resultados das variáveis estudadas foram submetidos à análise de variância e Teste de Tukey a 5% de probabilidade e à análise de regressão, para as variáveis quantitativas, quando o resultado da ANAVA foi significativo. Diante dos resultados obtidos, concluiu-se que extrato aquoso de eucalipto não apresentou efeito negativo sobre a germinação e desenvolvimento de plantas de rúcula.
Reflexões sobre Grupos Operativos no controle ao tabagismo à luz de Pichon Rivière
Authors: Souza Vinícius Rodrigues de , Almeida Taís de Freitas Ferreira , Valente Geilsa Soraia Cavalcante , Costa Andreia Jorge da , Almeida Inez Silva , Costa Janaína Loureiro da , Barreto Livia Luiza Gomes , Souza Marcela Teixeira de
Published: November 2021

Introdução: Segundo a Organização Mundial de Saúde (OMS) o tabagismo é responsável pela morte de mais de 8 milhões de pessoas por ano. A realização de grupos operativos em saúde tem sido amplamente utilizada para o programa de cessação do tabagismo. Objetivo: Refletir sobre a aplicabilidade das teorias de grupos operativos na cessação do tabagismo, na perspectiva de Pichon Rivière. Metodologia: Trata-se de um estudo de reflexão, fundamentado na teoria pichoniana, desenvolvido na disciplina “Metodologia de Trabalho em Grupo”, da Pós-Graduação Stricto Sensu da Faculdade de Enfermagem da Universidade Federal de Minas Gerais. Resultados e Discussão: Foram geradas duas categorias temáticas que subsidiaram a reflexão proposta. A aplicabilidade de Grupos operativos na cessação do tabagismo permite observar a importância da definição dos papeis dos elementos de um grupo de tabagismo, bem como associar os indicadores do processo grupal. Além disso, permitiu refletir sobre a importância do vínculo entre diversos indivíduos, facilitando o processo de abandono do ato de fumar. Conclusão: O Grupo Operativo como estratégia para pacientes que desejam cessar com o tabagismo apresenta diversos benefícios, visto que em grupo, cada membro pode entender os medos e as ansiedades pelos quais o outro está passando, refletindo e discutindo suas ações e pensamentos.
Força e massa muscular em idosos do Nordeste brasileiro
Authors: Santos Lucas dos , Santana Pabline dos Santos , Caires Sabrina da Silva , Barbosa Raquel dos Santos , Rodrigues Samara Carolina , Almeida Cláudio Bispo de , Valença Neto Paulo da Fonseca , Casotti Cezar Augusto
Published: November 2021

Este estudo teve como objetivos mensurar a força e a massa muscular de idosos de um município de pequeno porte do nordeste brasileiro; investigar as diferenças entre sexos e grupos etários; e correlacionar a força e a massa muscular na população de estudo. Trata-se de uma pesquisa epidemiológica populacional e transversal, realizada com 211 idosos de Aiquara-BA. A força de preensão manual (FPM) foi aferida por um dinamômetro hidráulico. Já a massa muscular total e o índice de massa muscular foram estimados por equações antropométricas. Os pontos de corte para o diagnóstico da dinapenia e da baixa massa muscular (MM) foram identificados por sexo (percentil 25 da FPM; percentil 20 do índice de massa muscular). Os resultados mostram que, em ambos os sexos, os idosos mais jovens dispunham de maior FPM e MM. Observou-se, também, que os homens apresentaram maior FPM, massa muscular total e índice de massa muscular. No referido sexo, verificou-se, ainda, correlação positiva moderada entre a FPM com a massa muscular total e fraca com o índice de massa muscular. Nas mulheres, averiguou-se correlação positiva fraca da FPM com a massa muscular total. Ademais, identificou-se que a dinapenia e a baixa MM foram mais prevalentes nos idosos com idade ≥80 anos. As evidencias averiguadas mostraram que as mulheres e os idosos mais velhos dispunham de menor FPM e MM. Em ambos os sexos houve correlação positiva da FPM com MM. Além do mais, a dinapenia e o déficit de MM foram mais frequentes nos longevos.
Adenoma pleomórfico em mucosa jugal: relato de caso
Authors: Barros Flávia de Paiva Teixeira , Acioly Gabrielly Maria Argolo , Matos Camila Holanda Cavalcante , Mendes Carla Beatriz dos Anjos , Miranda Renata Cordeiro de Godoy , Lins Beatriz Nunes , Alcântara Gabriel Alencar Lemos de , Santos Taj Mahal Wanderley , Franco Aurea Valeria de Melo , Panjwani Camila Maria Beder Ribeiro Girish , Santos Vanessa de Carla Batista dos , Peixoto Fernanda Braga
Published: November 2021

Objetivo: Destacar a relevância diagnóstica na prática odontológica clínica, buscando a correta conduta no tratamento do adenoma pleomórfico em região de mucosa jugal, bem como discutir a patogênese da lesão. Detalhamento do caso: Paciente do sexo masculino, 64 anos, compareceu a Clínica Escola de Odontologia queixando-se de lesão assintomática que surgiu de forma lenta há aproximadamente 8 meses. Ao exame intraoral foi observada uma lesão nodular e única em mucosa jugal, de coloração branca, avermelhada e amarelada, superfície lisa, bem delimitada, de formato oval e consistência firme. A hipótese de diagnóstico foi de lipoma. Optou-se pela biópsia excisional para confirmação da lesão através do estudo anatomopatológico. Considerações finais: A realização da biópsia é imprescindível, a fim descartar outras hipóteses diagnósticas. É importante que o profissional cirurgião-dentista tenha capacitação técnica para propor o tratamento mais adequado, devolvendo bem-estar, autoestima e saúde do paciente, enquanto mantém um prognóstico satisfatório.
Atribuições dos profissionais fisioterapeuta e educador físico no atendimento home care de pacientes pós Covid-19
Authors: Macedo Mayara Cardoso , Mendes Bárbara Lira Bahia
Published: November 2021

A doença por coronavírus no qual afetou a população mundial, teve um grande índice de recuperados em 2021, de acordo com os dados do ministério da saúde. As sequelas que acometem os recuperados envolvem principalmente dispneia, fadiga muscular, dificuldades neurocognitivas e consequentemente diminuição do condicionamento físico. Após o período hospitalar, é necessário que os pacientes busquem profissionais para tratamento, onde teve grande destaque o atendimento home-care. O acompanhamento multidisciplinar é de extrema importância, onde o objetivo desta revisão é apresentar as contribuições e diferenças no atendimento domiciliar de paciente pós Covid-19 dos fisioterapeutas e educadores físicos, que apesar de terem semelhanças quanto a utilização de exercícios físicos em seus atendimentos, os objetivos terapêuticos são divergentes, entretanto, ambos contribuem de forma significativa nas etapas de reabilitação domiciliar. Os conselhos federais são os que determinam as atribuições de cada um no tratamento dessa patologia, pois apesar de ainda estar em processo os estudos envolvendo o vírus SARS-CoV-2, existe as comprovações dos benefícios proporcionados por cada profissional na fase pós hospitalar.
Alterações no paladar advindos de quimioterapia convencional
Authors: Silva Eduardo Henrique dos Santos , Aguiar Yuri Lopes de , Amaral Polyana Argolo Souza , Pereira Lara Correia
Published: November 2021

O câncer está ligado ao aumento desordenado de células, possui a capacidade de invadir tecidos vizinhos no local de origem e/ou instalar-se em órgãos distantes via corrente sanguínea. O tratamento antineoplásico pode gerar efeitos colaterais, na mucosa oral, ficando evidente através do surgimento da mucosite oral. Também podemos observar alterações no paladar, como: hipogeusia, disgeusia, ageusia e hipergeusia. O presente trabalho visa revisar a literatura acerca das alterações do paladar provocadas por 5-fluoruracila (5-FU), leucovorine, oxaliplatina, gencitabine, capecitabine, cisplatina, ciclofosfamida, doxorubicina, irinotecan e metotrexato, sendo medicamentos antineoplásicos convencionais. Este estudo foi realizado através do levantamento de dados no período de 2009 até 2021, a partir da literatura científica na base de dados PubMed, Lilacs, Cochrane e Scielo em língua inglesa e espanhola, valendo-se das palavras chaves Antinéoplasicos; Paladar Distorcido; Disgeusia; Estomatite; Cavidade Oral; juntamente com os operadorer booleanos “and” e “or”, de forma a combinar os descritores citados.  Diante do exposto, os fármacos quimioterápicos convencionais afetam as células gustativas e os processos bioquímicos referentes a sua renovação celular, gerando alterações no paladar como hipogeusia, disgeusia, ageusia e hipergeusia.