bluuebunny/crossref_metadata_2025 huggingface dataset:
High School and curriculum flexibilization: analysis of scientific productions between 2015-2022
Authors: Baruffi Pedro Paulo , Ens Romilda Teodora , Oliveira José Luis de , Taverna Aline Rosenente
Published: June 2023

In this article, we map the scientific productions on curriculum flexibility in High School between 2015 and 2022. We use a qualitative approach, in a study that is characterized as state-of-the-art research, in sources such as: Scielo, BDTD, Capes Periódicos and Catalog of Theses and Dissertations. We identified 25 works, 14 articles, 8 dissertations and 3 theses. From the cloud of words performed, after the corpus with the abstracts, processed by the IRAMUTEQ software, we infer that the results indicate that curricular flexibility reinforces neoliberal and entrepreneurship interests in education, aimed at training young people who adapt and accept capitalism, limit access to scientific knowledge and comprehensive training. Such aspects open gaps for training around privative interests that increase the inequalities already so marked by society.
AS DETERMINAÇÕES DO CAPITAL NAS DIRETRIZES OPERACIONAIS DA EDUCAÇÃO DE JOVENS E ADULTOS
Authors: Soriano Giovan Nonato Rodrigues , Farias Adriana Medeiros , Fernandes Maria Nilvane
Published: June 2023

O presente artigo tem por objetivo discutir as últimas Diretrizes Operacionais para a Educação de Jovens e Adultos (EJA), assentadas na Resolução MEC/CNE/CEB n.º 1, de 28 de maio de 2021, dentro do atual processo de contrarreforma e subsunção da educação brasileira às determinações do capital no âmbito do seu projeto orgânico burguês de deterioração e mercantilização da educação pública estatal. A análise se vincula a uma pesquisa documental, referenciada no materialismo histórico-dialético.Ao final, infere-se que o planejamento, o financiamento e a execução da educação pública pelo Estado enfrentam resistência das classes dominantes desde a sua origem e, com as reconfigurações impostas pelas crises do capitalismo, têm se tornado um importante campo de disputa mundial, na qual os Estados nacionais têm operado profundas reformas de modo a beneficiar a sua direção e exploração pela inciativa privada, como ocorre no Brasil, em que as novas Diretrizes Operacionais favorecem o alinhamento da EJA às contrarreformas sistêmicas e, por conseguinte, desobrigam ainda mais o Estado pelo seu provimento, favorecem a expropriação do direito dos sujeitos dessa modalidade de ensino de terem acesso aos conhecimentos historicamente produzidos e legitimam uma educação fictícia voltada apenas à certificação.
Pendampingan Industri Halal dalam Menumbuhkembangkan Usaha Mikro Melalui Ekonomi Kreatif
Authors: Astuti Ristina Wahyu , Zihab Zihab , Solatiyah Baiq , Febrian Dodi , Saripudin Saripudin , Hernawati Hernawati
Published: June 2023

Efforts to increase economic growth in Indonesia, the discourse that is often discussed is the use of the creative economy concept. In connection with the government's efforts to realize creative economic development and create halal products, the position of the government in increasing MSMEs is urgently needed. The purpose of this community service is to provide training on the latest insights to all parties involved in developing micro-enterprises through the creative economy. The method of implementing the activity consists of several stages. In the preparatory stage the team conducted a location survey, strengthening and determining target locations, and preparing socialization materials. In addition, participants participated in assistance in making halal products. The implementation stage of the program is in the form of lectures or outreach, tutorial activities, discussions and MSME training assistance. The material presented in the socialization is in the form of an introduction to the production process of halal products and provides direction in making halal labels. The results and outputs of the activities after the socialization was carried out, namely first, introducing the production process for halal products to the public, in this case the socialization team provided an understanding of how important the distribution of industrial potential is through the creative economy. Second, provide assistance in the form of making halal labels where at this stage the socialization team provides an understanding that in Islam products cannot contain harmful ingredients because they will have a negative impact on consumers and society.
Analisis Peran Internal Audit Dalam Penerapan Pengendalian Operasional (Studi Kasus PT. Perkebunan Nusantara XI)
Authors: Rachmawati Cindhy Pramita , Amiranto J.B
Published: June 2023

Penelitian ini bertujuan untuk mengetahui apakah penerapan Audit Internal pada PT. Perkebunan Nusantara XI menerapkan pengendalian internal yang tepat untuk meningkatkan efisiensi dan efisiensi operasional perusahaan. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus (case study). Teknik pengumpulan data yang digunakan dalam penelitian ini adalah melalui wawancara, yaitu tanya jawab langsung dengan auditor internal perusahaan untuk mengetahui perkembangan dan kegiatan perusahaan, dan observasi yaitu pengamatan yang dilakukan secara langsung tanpa perantara terhadap objek. Berdasarkan data hasil penelitian yang dianalisis, dapat disimpulkan bahwa kriteria pengendalian internal menurut COSO (2013) hasil kondisi dari PT Perkebunan Nusantara XI telah melaksanakan pengendalian internal dengan baik ditandai oleh direksi perusahaan telah memberikan asersi secara tertulis dalam Laporan Keuangan audited tahun 2021. Namun, pada tahun 2020 pernah terjadi penyimpangan penerapan Standar Operasional Perusahaan (SOP) di PT. Perkebunan Nusantara XI yang berakibat pada terjadinya penyalahgunaan persediaan gula di pabrik gula. Terdapat oknum pekerja gudang yang melakukan manipulasi data sehingga mengakibatkan kerugian bagi perusahaan. Namun, PT. Perkebunan Nusantara XI ini telah memperbaiki pengendalian internal perusahaan dengan cara memperketat pelaksanaan SOP. Implikasi penelitian ini dapat mengetahui sejauh mana progres yang dilaksanakan oleh karyawan apakah sudah sesuai dengan standar atau rencana kerja, apakah sumber daya telah digunakan sesuai dengan apa yang telah ditetapkan.
Produksi Dalam Sistem Perekonomian Menurut Pandangan Al-Qur`an
Authors: Tomadehe Sumiati , Abubakar Achmad , Haddade Hasyim
Published: June 2023

Produksi sangat penting bagi kelangsungan hidup dan peradaban manusia dan bumi. Sesungguhnya produksi lahir dan tumbuh dari menyatunya manusia dengan alam. Manusia diciptakan sebagai khalifah untuk mengelola dan memanfaat bumi dan segala isinya dengan optimal dan cara-cara yang sesuai syariat. Manusia memakmurkan bumi agar manusia dapat memenuhi kebutuhan yang diinginkannnya. Allah telah SWT memberikan penjelasan dari ayat-ayat Al-Qur`an bagaimana seharusnya manusia mengolah Bumi atau melakukan aktifitas produksi. Berdasarkan telaah normatif ayat-ayat Al-Qur’an, diperoleh hasil kajian dari penelitian ini bahwa peran produksi dalam perekonomian perspektif Al-Qur`an adalah sebagai ungkapan rasa syukur atas nikmat alam semesta yang diciptakan Allah SWT, sebagai pendongkrak kreatifitas manusia, dan sebagai sarana untuk menyebarluaskan kemaslahatan yang tidak hanya berorientasi pada keuntungan materi semata.
Kunci Pelaksanaan Kegiatan Logistik Halal di Indonesia Dalam Praktik Logistik Global
Authors: Suhairi Suhairi , Prameswari Ardhia , Octavia Dindy Rizka , Bayani Luthfiah Nur
Published: June 2023

Penelitian ini bertujuan untuk mengetahui strategi atau hal penting yang harus dilakukan agar logistik halal di Indonesia dapat terlaksana atau tercapai secara efektif dalam lingkup logistik global. Adapun untuk metode penelitian yang digunakan adalah penelitian deskriptif kualitatif melalui studi kepustakaan (literature review) yang dimana menjelaskan fenomena dan data serta penelitian terdahulu, kemudian menarik kesimpulan dari permasalahan yang ada secara lebih akurat dan jelas dari fakta-fakta yang ada. Untuk hasil penelitian ini ialah terdapat beberapa hal penting yang dapat menjadi pendorong kesuksesan Logistik Halal di Indonesia yang diantaranya yaitu 1) Dukungan pemerintah untuk mendorong perkembangan Logistik Halal dengan memperketat kebijakan mengenai sertifikasi halal 2) Memberikan pelatihan dan peningkatan manajemen pengetahuan yang berperan meningkatkan kemampuan pegawai. 3) Pengembangan Lanjutan dalam hal teknologi meliputi pengembangan sistem pelacakan seperti penambahan sistem sensor DNA dan sertifikasi di pergudangan, distributor, dan penjual, serta sertifikasi di penyedia produk hingga penjual ditambah dengan penerapan sistem logistik lima titik pembelian untuk inovasi berkelanjutan dan pengurangan biaya.
APPLICATION OF RED DRAGON FRUIT ON HEALING MUCOSAL WOUNDS OF WISTAR RAT
Authors: Kusumadewi Sari , Dina Sintya Dewi Komang , Anggita Dewi Hartayani IGAA , Da Silva Pinto Viata
Published: June 2023

Red dragon fruit contains flavonoids that play role in wound healing. The purpose of this study was to determine the effect of red dragon fruit on the healing of oral mucosal wounds of Wistar rats. The research method used post test only control group design by making 3 groups: treatment, positive and negative control. Each group was further divided into 3 small groups based on time: 3, 5 and 7 days, so there were total of 9 small groups with 4 rats each. The research data were analyzed for normality test with Saphiro-Wilk, homogeneity with Levene's test, followed by two-way ANOVA test and LSD Post Hoc. The results were divided into 3 observation groups. Group-1 Epithelial cell thickness: The highest mean value of epithelial cell thickness was in the treatment group on days 3 and 5. Group-2 Number of fibroblast cells: The highest mean value of fibroblast cell: treatment group (63.22) > control group (56.22) > negative group (47.44). Group-3 Angiogenesis: The highest mean angiogenesis value was in the treatment group on days 3 and 5. It was concluded that the application of red dragon fruit (Hylocereus polyrhizus) affected the healing of wistar rats (Rattus norvegicus) buccal mucosal wounds.
MINI DENTAL IMPLANT AS TREATMENT OF CHOICE IN A LATE TOOTH AVULSION WITH BONE RESORBTION: CASE REPORT
Authors: Goenawan Hans , Goreti Widiastuti Maria , Fuadi Muhammad , Maulana RIzqan
Published: June 2023

Tooth avulsion is a severe condition of traumatic dental injury. The long-time effect of untreated tooth avulsion is alveolar bone loss. The mini dental implant can be a treatment for single tooth replacement in a late tooth avulsion with bone resorption. The purpose of this study is to present a case report of the mini dental implant in a late avulsion of an anterior maxillary tooth without bone augmentation. Thirty years old male patients came to clinic with the left upper central incisor avulsed due to a traffic accident three years before. There has been mild vertical and horizontal bone resorption and diastemas. He wanted to replace the missing tooth with a fixed denture, and the patient refused any bone augmentation. The mini dental implant was an alternative treatment for this case. Orthodontic treatment was performed to regain space before mini dental implant placement because some teeth had been migrated, causing some diastemas. After seven months of orthodontic treatment, we inserted a 3.0 x 13.0 mm nobel active implant bone level and installed the healing abutment. The prosthetic crown was screwed carefully using a manual torque wrench with a maximum torque force not exceeding 15 Ncm. The mini dental implant could be a treatment for a late avulsion case without bone augmentation.
DESCRIPTION OF EARLY CHILDHOOD CARIES WITH CHRONOLOGICAL AGE OF DENTAL IN PRESCHOOL CHILDREN AT RSGM UNJANI
Authors: El Fithriyah Rhabiah , Hartman Henri , Yudistira Farhan
Published: June 2023

Early Childhood Caries (ECC) is a chronic disease in children that is most common under 71 months and is a multifactorial disease that can be seen directly (Intra Oral) or by radiographs. This study aims to determine the picture of ECC at preschool age assessed through radiographs. This research method is a descriptive observational study with a cross-sectional approach. The number of research subjects was 39 from the radiological data of the RSGM UNJANI. Sampling was in accordance with the inclusion and exclusion criteria, consisting of radiographs aged 3-5 years. The study was conducted by assessing the level of tooth decay in children using radiographs. Data processing using SPSS with the univariate analysis aims to describe the chronological Age and Early Childhood Caries using frequency distribution and percentage. The results of this study indicate that children aged 3-5 years are susceptible to early caries. This study concludes that ECC occurs mainly in preschool children with severe categories.
Episodic Odor Recognition Memory Is Reflected in Narratives About the Earliest Memories in Older Adults
Authors: Sabiniewicz Agnieszka , Stefańczyk Michał , Sobol Małgorzata , Palmiero Massimiliano
Published: June 2023

Many studies have shown that the characteristics of odor-evoked memories differ from the characteristics of memories evoked by other senses. So far, no research has specifically investigated the relationship between odor memory and the quality of memories without using an odor trigger. The purpose of this study was to explore the link between episodic odor recognition memory and the linguistic and semantic content of autobiographical narratives about the earliest memories of older adults by a methodological approach deprived of odor stimuli. A sample of 112 older adults aged 59 to 101 years old was recruited. Odor memory was measured via the Sniffin’ Test of Odor Memory, and the linguistic and semantic content of memories was measured via the Linguistic Inquiry and Word Count system. The results showed that episodic odor recognition memory was a predictor of the number of first-person pronouns and number of words concerning cognitive processes in the narratives about the earliest memories. Implications for memory and future research directions are discussed.
Young and Senescent Cells: Distinct Nuclear F-actin Patterns Upon Latrunculin B Induction
Authors: Huang Dichun
Published: June 2023

Both cellular senescence and cytoskeleton are involved in the formation of many diseases and cell signaling pathways. Although recent studies have shown that F-actin is involved in DNA damage repair, chromatin decompression, gene transcription regulation, and cell fate determination. But studies on F-actin and aging are still absence. It is unclear whether nuclear F-actin is present during cellular senescence. Here, by confocal optical sectioning and time-lapse imaging, we found acitn chrommobody-TagGFP2-NLS shows the beneficial on investigating senescent human fibroblast IMR-90 cells. To induce the nuclear F-actin assembly in single cell, we uesd Latrunculin B (latB) which a cytoplasmic F-actin polymerization inhibitor. It is currently unknown whether the nuclear F-actin cytoskeleton in young and senescent cells responds differently to latB treatment. Here, latB application induces distinct nuclear F-actin patterns and dynamics in young and senescent cells. Thus, after analyzing the results of actin dynamic we demonstrate a diverse effect of latB on the nuclear F-actin cytoskeleton in young and senescent cells.
Progress in the Application of Targeted Agents in Non-small Cell Cancer
Authors: Long Zhihao
Published: June 2023

Research subject: primary targeted preparation, that is, the drug is released from the capillary bed into the target site; Secondary targeted preparation, that is, drug release from special cells (such as tumor cells) entering the target; Tertiary targeted preparations are drugs that act on certain parts of cells. Research methods: Compared with traditional preparations, targeted preparations can improve drug selectivity, reduce adverse reactions, enhance efficacy and improve patient compliance, and become the focus of new drug research and development. Therefore, scientific and reasonable targeted evaluation techniques and methods should be established based on this point to improve the safety, effectiveness and quality control of such drug preparations. Objective: This paper reviews the targeted application of anti-tumor targeting agents, and introduces the targeted technology and application from the aspects of targeting and pharmacology, so as to provide reference for the development trend of anti-tumor targeting agents in the future. Conclusion: According to the study, attention should be paid to improving the drug encapsulation rate and drug loading, and increasing the drug stability, so as to obtain drug preparations with large drug loading, good stability and strong targeting.
Comparison of Allocation Strategies of Specialized Physicians
Authors: Zhang Xuan
Published: June 2023

As an aging population increases the demand for medical care, hospitals will have to increase the number of medical equipment and examiners to cope with the surge in demand for medical tests due to increased dependence on diagnostic equipment. However, doctors have different abilities and patients have a variety of diseases. Therefore, less skilled physicians cannot serve patients with complex diseases and need to consult jointly with more skilled physicians. This paper considers the influence of setting the service ability of physician system separately, studies the waiting time and queue length of patients in two systems with and without specialized physicians, and optimizes the configuration mode of physicians. It is found that when the consultation rate is higher than the threshold value, the optimal decision under the condition of not overloading is not to set a specialist. When the consultation rate is below the threshold, a specialist is appointed.
Nuclear Actin Puncta in Senescent Cells
Authors: Mai Haiying
Published: June 2023

Both cellular senescence and the nuclear actin cytoskeleton participate in a plethora of physiological and pathological activities. However, their connection remains elusive. Recently, it is becoming increasingly apparent that filamentous actin plays important functions within the nucleus. Particularly, micron-scaled actin filaments (hereinafter referred to as F-actin) in the nucleus are of the essence in DNA damage repair, cell fate determination and age-related diseases etc. Latrunculin B (latB), a pharmaceutically applicable macrolide, can induce nuclear F-actin assembly. Now it is unclear how the nuclear actin skeleton responds to latB stimulation in senescent cells. Here, by time-lapse images, Doxo-induced senescent IMR-90 cells showed a large number of nuclear actin puncta, then the nuclear actin puncta become brighter and larger in size upon latB treatment. Some actin puncta even served as the elongation bases for the nuclear F-actin. Therefore, our results link the nuclear actin skeleton to cell aging and reveal the effect of latB treatment on the nuclear actin skeleton in aging cells.
Research Progress on the Synthesis of Flavonoids by Saccharomyces Cerevisiae
Authors: Luan Tao
Published: June 2023

As a food-safe microorganism, Saccharomyces cerevisiae is widely studied in metabolic engineering and synthetic biology, and can be used as a cell factory to produce natural compounds. Flavonoids are valuable natural products with multiple biological activities such as estrogen, antioxidant, antibacterial and anticancer activities, and are widely used in food, medicine and other fields. However, the development and utilization of flavonoids is limited by problems such as low concentration and long cycle in obtaining them from plants. With the development of metabolic engineering technology and synthetic biology, the synthesis of flavonoids through microbial cell factories has good prospects. Based on microbial synthesis of flavonoids, this paper comprehensively reviews the research progress of some flavonoids synthesized in S. cerevisiae, summarizes and prospects the current difficulties and challenges as well as future research directions.
Drug Resistance Mechanism and Detection Method of Salmonella
Authors: Li Chengyu , Jiang Zhaoxu , Liu Zhenhai , Dong Xiaorui , Zhu Liping , Yan Shigan
Published: June 2023

As an important zoonotic food-borne pathogen, Salmonella is a concern for public health authorities. In particular, bacteria that are resistant to multiple antimicrobials can confuse the efficacy of treatment for infectious diseases. Drug-resistant bacteria have a variety of drug-resistant molecular and cellular mechanisms. These antimicrobial resistance mechanisms include antibiotic efflux, permeability changes in cell membranes, enzymatic drug inactivation, biofilm formation, drug target changes, and protection of antimicrobial targets. In this paper, the mechanisms of antimicrobial resistance in salmonella and the techniques of detecting antibiotic resistance by traditional and molecular methods are reviewed, with emphasis on their advantages and disadvantages, as well as the validity and reliability of the results.
Analysis of the Current Situation and Trends of the Development of Big Health Industry
Authors: Qian Hanson
Published: June 2023

The medical and health industry aims to maintain and promote people's physical and mental health, including medical services, health management and promotion, health insurance and related services. Compared with the traditional health industry, the big health industry does not sell a single product, but provides solutions for people to live a healthy life, thus creating greater business opportunities. The report of the 19th National Congress stressed the development of the health industry and the building of a healthy China. Health industry is an emerging industry with huge market potential, and it has the characteristics of "broad employment prospects, large consumption demand, and promoting the health and longevity of citizens".
Research on the Application of Blockchain Technology in the Design of Analgesic Drug Supply Chain
Authors: Liu Linyu
Published: June 2023

The supply chain of analgesic drugs has many circulation links and trading levels, and the trading channels are complex; Information asymmetry and low logistics efficiency; Wholesale links account for a large proportion of costs. Too many trading links and complicated trading channels make the trading information asymmetric, opaque and disorderly, which will inevitably lead to the loss of efficiency and benefit in the circulation process. In this paper, the application of blockchain technology in the design of analgesic drug supply chain is studied. The analgesic drug data management center is maintained by the pharmaceutical enterprises themselves or the third party, which is mainly responsible for distributing the unique identification code of drugs, backing up all records of the whole cycle of drug production, storage, circulation and sales, and realizing the two-way traceability function of drugs. In the production process, pharmaceutical enterprises attach electronic labels from single products and outer packaging boxes to realize the traceability and anti-counterfeiting of drugs throughout their life cycle. Correspondingly, it also integrates the advantages and disadvantages of self-management and outsourcing. At this stage, enterprises can choose to subcontract non-core logistics business first, so that enterprises can focus on their core business and avoid wasting too much money and energy in logistics.
Clinical Efficacy of Neoadjuvant Endocrine Therapy in Non-Metastatic Prostate Cancer and Preliminary Experiences of Bone Metastasis Patients
Authors: Jiang Yu , Xu Qiao , Wan Shihao , He Yunfeng
Published: June 2023

Objective To explore the short-term efficacy of neoadjuvant endocrine therapy (NET) for localized prostate cancer and preliminary exploration of NET in patients with bone metastases. Methods Analyze clinical data of patients undergoing radical prostatectomy (RP) in the First Affiliated Hospital of Chongqing Medical University from January 2017 to January 2021 retrospectively. Patients with localized prostate cancer undergoing NET+RP were selected as the experimental group. The ones who only received RP were chosen as the control group, and the peri- and post-operative outcomes such as down-staging, pathological complete response, positive margin, intraoperative blood loss, and operation time were compared between the two groups. In addition, collect the information of patients with bone metastatic prostate cancer, excluding organ metastases, who received NET+RP over the same time-period and analyzed the short-term efficacy and quality of life. Results In the experimental group, there were more down-staging (13.08% vs. 4.67%, P=0.031), more pathological complete response (12.15% vs. 0.93%, P=0.001), less positive margin (9.35% vs. 29.91%, P< 0.001) and less blood loss (171.45±16.19 vs. 177.76±23.28, P=0.022). NET+RP also showed a satisfying short-term efficacy in patients with bone metastases, with well quality of life. Conclusion NET combined with RP can provide good short-term prognosis and patient satisfaction in patients with prostate cancer, and it is a potential option for patients with bone metastases without organ metastases.
L’analogia nel De veritate di Tommaso d’Aquino: tra capacità euristica e trascendenza divina
Authors: Gambi Giovanni
Published: June 2023

I tentativi attuati all'interno della tradizione tomista per individuare la dottrina ufficiale dell’analogia elaborata da Tommaso d’Aquino si sono dovuti confrontare con la varietà di distinzioni tracciate dall’Aquinate nei suoi scritti. In particolare, l’importanza inedita assegnata alla convenienza di proporzionalità nelle Quaestiones disputatae de veritate ha suscitato un dibattito secolare, che oppone quanti riconoscono in questa soluzione la dottrina autentica a coloro che la valutano meramente come uno stadio provvisorio all’interno di un’evoluzione riscontrabile nelle opere di Tommaso. Nel presente contributo si intende segnalare alcuni dati testuali che aiutano a chiarire il passaggio dalla concezione dell’analogia presentata nello Scriptum super sententiis a quella del De veritate, un passaggio strettamente legato alla funzione euristica svolta dall’analogia.
 
The attempts made within the Thomist tradition to identify the official doctrine of analogy elaborated by Thomas Aquinas had to deal with the various distinctions drawn by Aquinas in his writings. In particular, the great importance given to the agreement of proportionality in the Quaestiones disputatae de veritate has elicited a long debate, in which those who consider such a solution as the authentic doctrine are opposed to those who see it merely as a temporary stage of an evolution which could be observed in Thomas’s works. The aim of this essay is to present some textual data that contribute to clarify the transition from the analogy as conceived in the Scriptum super Sententiis to that of the De veritate, a transition closely related to the heuristic function of analogy.
EFFICACY AND SAFETY OF TRIAMCINOLONE ACETONIDE INJECTION IN SUPRACHOROIDAL SPACE IN SUBJECTS WITH DIABETIC MACULAR EDEMA
Authors: FATIMA M , ABBAS S , SAJJAD T
Published: June 2023

This study aimed to assess the effectiveness and safety of triamcinolone acetonide administered through suprachoroidal space in subjects with diabetic macular edema. A prospective study was conducted in the Department of Ophthalmology, Nishtar Hospital, Multan, from April 2022- April 2023. A total of 40 patients with diabetic macular edema by optical coherence tomography were included in the study. During surgery, 4mg/100 µL triamcinolone acetonide was injected. The patients were followed up for a week to evaluate post-injection adverse effects. In addition,It was noted that the injection improved the VA significantly. After 6 months of follow-up, the VA was 0.69 ± 0.1 (p<0.001). Significant improvement was seen in optical coherence tomography measurement; after 6 months, it was reduced to 265.6 ± 39.1 µm (p<0.001). No significant difference was noted in intraocular pressure from baseline to follow-up. Based on the results, administering triamcinolone acetonide through suprachoroidal space in diabetic macular edema is effective without any adverse effects.
IMPACT OF DIABETES ON LONG-TERM OUTCOMES IN STEMI PATIENTS UNDERGOING PRIMARY ANGIOPLASTY WITH GLYCOPROTEIN IIB-IIIA INHIBITORS AND BARE METAL STENTS (BMS) OR DRUG-ELUTING STENTS (DES)
Authors: KHAN RD , MAQSOOD S , KHAN MA , ALI N , KHAN IU , AHMAD Z
Published: June 2023

This study aimed to investigate the impact of diabetes on long-term outcomes in STEMI patients undergoing primary angioplasty with glycoprotein IIb/IIIa inhibitors and either BMS or DES. The study was conducted at the interventional cardiology department of HMC and included 278 patients between March 6, 2022, and September 5, 2022. Inclusion criteria were STEMI patients undergoing primary angioplasty, while exclusion criteria were patients with chronic total occlusion, left main disease, and previous PCI or CABG. Data collection was done through chart review and patient follow-up for one year. Diabetic patients had a higher incidence of multivessel disease, and there was a trend towards a higher rate of Major-adverse-cardiac-events (MACE) and Target Vessel Revascularization (TVR) at long-term follow-up. Drug-eluting stents (DES) were associated with a lower TVR incidence than BMS. Our study highlights the negative impact of diabetes on long-term outcomes in STEMI patients undergoing primary angioplasty with glycoprotein IIb/IIIa inhibitors and either BMS or DES. Further studies are needed to confirm these findings and explore potential mechanisms underlying the adverse cardiovascular outcomes in diabetic patients with STEMI. Ultimately, improving the care of diabetic patients with STEMI is critical to reducing morbidity and mortality in this high-risk population.
COMPARATIVE STUDY OF HEMODYNAMIC RESPONSE USING LARYNGEAL MASK AIRWAY (LMA) VERSUS ENDOTRACHEAL TUBE (ETT) IN CONTROLLED HYPERTENSION PATIENTS
Authors: ABIDIN ZU , WADOOD R , AHMED N , ABBASI T , ULLAH A , KHAN IU
Published: June 2023

In the practical conduct of Anaesthesia, Airway management is crucial to the outcome & best patient care. A total of n=114 patients,30-50 yrs with mean age 38.736± 4.36 years; 57 each group of Laryngoscopy and ETT; and LMA group undergoing elective surgery of 30 minutes to 01-hour duration in controlled hypertensives were included in the study. The hemodynamic response was noted, recording pulse rate, Systolic BP, Diastolic BP, and MAP immediately after 1,3,5 minute of laryngoscopy & intubation or LMA insertion. The study results showed a hemodynamic response of 59.6% in patients of the Laryngoscopy & ETT group compared to 40.4% in the LMA group. The study revealed attenuated hemodynamic response to LMA insertion with improved hemodynamic; stability compared to laryngoscopy & intubation. The results advocate using supraglottic airway devices, especially LMA merits, in selected patients & circumstances.
COMPARATIVE STUDY FOR DIFFERENT PREVENTIVE METHODS FOR POSTPARTUM HEMORRHAGE (PPH)
Authors: ABBASI M , SIDDIQUI ES , GHAFFAR S , HEMLATA DR , JABEEN N , QARSHI W
Published: June 2023

Different preventive methods have been used to reduce the incidence of PPH, but their efficacy, safety, and cost-effectiveness have not been well established. We conducted a comparative study to evaluate the effectiveness, side effects, and cost of different preventive methods for PPH. 120 patients at LUMHS from 2021 to 2022 were randomly assigned to receive one of four preventive methods: oxytocin, misoprostol, tranexamic acid, or prophylactic balloon catheterization. Data on the incidence of PPH, mean blood loss, need for additional interventions, and adverse events were collected and analyzed using logistic regression and ANOVA. The incidence of PPH was significantly lower in the tranexamic acid group (4%) and the prophylactic balloon catheterization group (6%) compared to the oxytocin group (16%) and the misoprostol group (14%). The mean blood loss was also significantly lower in the tranexamic acid and the prophylactic balloon catheterization groups than in the oxytocin and misoprostol groups. The need for additional interventions and adverse events were also significantly lower in the tranexamic acid and prophylactic balloon catheterization groups. Our study provides evidence to support tranexamic acid and prophylactic balloon catheterization as effective and safe preventive methods for PPH, with minimal side effects and low cost. Oxytocin remains a viable option for preventing PPH, but misoprostol should be used cautiously due to its higher incidence of adverse events.
Hacia una genealogía tecno-estética del gesto en Latinoamérica / Towards a Techno-aesthetic Genealogy of Gesture in Latin America
Authors: Domínguez Jiménez Román
Published: June 2023

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Rapid Identification of Jasmine Virus H Infecting Ixora coccinea by Nanopore Metatranscriptomics
Authors: Kim Sung-Woong , Lee Hyo-Jeong , Choi Sena , Cho In-Sook , Jeong Rae-Dong
Published: June 2023

The global climate change and international trade have facilitated the movement of plants across borders, increasing the risk of introducing novel plant viruses in new territories. Ixora coccinea exhibited virus-like foliar symptoms, including mosaic and mild mottle. An Oxford Nanopore Technologies-based compact and portable MinION platform was used to identify the causal viral pathogen. The complete genome sequence of jasmine virus H (JaVH; 3867 nt, JaVH-CNU) was determined and found to share 88.4-90.3% nucleotide identity with that of Jasminum sambac JaVH isolate in China. Phylogenetic analysis based on the complete amino acid sequences of RNA-dependent RNA polymerase and coat protein revealed that JaVH-CNU was grouped separately with other JaVH isolates. This is the first report of a natural JaVH infection of >i<I. coccinea. The application of rapid nanopore sequencing for plant virus identification was demonstrated and is expected to provide accurate and rapid diagnosis for virus surveillance.
Antifungal Activity of Green and Chemically Synthesized ZnO Nanoparticles against Alternaria citri, the Causal Agent Citrus Black Rot
Authors: Elshafie Hazem S. , Osman Ali , El-Saber Mahmoud M , Camele Ippolito , Abbas Entsar
Published: June 2023

Citrus black rot is a serious disease of citrus plants caused by Alternaria citri. The current study aimed to synthesize zinc oxide nanoparticles (ZnO-NPs) by chemically or green method and investigate their antifungal activity against A. citri. The sizes of synthesized as measured by transmission electron microscope of ZnO-NPs were 88 and 65 nm for chemical and green methods, respectively. The studied prepared ZnO-NPs were applied, in vitro and in situ, at different concentrations (500, 1,000, and 2,000 µg/ml) in post-harvest treatment on navel orange fruits to verify the possible control effect against A. citri. Results of in vitro assay demonstrated that, at concentration 2,000 µg/ml, the green ZnO-NPs was able to inhibit about 61% of the fungal growth followed by 52% of chemical ZnO-NPs. In addition, scanning electron microscopy of A. citri treated in vitro with green ZnO-NPs showed swelling and deformation of conidia. Results showed also that, using a chemically and green ZnO-NPs at 2,000 µg/ml in situ in post-harvest treatment of orange, artificially-infected with A. citri, has reduced the disease severity to 6.92% and 9.23%, respectively, compared to 23.84% of positive control (non-treated fruits) after 20 days of storage. The out findings of this study may contribute to the development of a natural, effective, and eco-friendly strategy for eradicating harmful phytopathogenic fungi.
MODELIRANJE I KRETANJE STOPE POVRAĆANJA NA ULAGANJE U OBRAZOVANJE U OKVIRU POSTAVKA TEORIJE LJUDSKOG KAPITALA
Authors: Vuksanović Nemanja
Published: June 2023

Cilj rada jeste da pruži uvid u ekonometrijsko modeliranje ocene stope povraćaja na ulaganje u obrazovanje u metodološkim okvirima teorije ljudskog kapitala. Posebno je istaknut problem endogenosti sa kojim se istraživači suočavaju, a koji se javlja usled izostavljanja neuočljivih karakteristika pojedinica, poput sposobnosti, što dovodi do precenjenosti ocene stope povraćaja na ulaganje u obrazovanje. U radu je pored eksperimentalnog metoda, opisan i metod instrumentalnih promenljivih, kao neeksperimentalni metod koji se može primeniti radi prevazilaženja problema endogenosti. Dodatno, u radu je predstavljen sumarni prikaz rezultata oko 700 studija sprovedenih u periodu od 1960. do 2010. godine, u kojima je ocenjena stopa povraćaja ulaganja u obrazovanje.
Lateral Cephalometric Analysis of Nasal Morphology in Patients Visiting Nishtar Institute of Dentistry
Authors: Jamshed Sameera , Zubair Hassan Awaisi  , Ahmed Zubair
Published: June 2023

Nasal morphology is the keystone of facial aesthetics. Being the most prominent part of the face, the shape and position of the nose greatly influence the facial profile and nasal soft tissue thickness also plays a vital role in orthodontic diagnosis and treatment planning. Objective: To evaluate the soft tissue nasal morphology in individuals presenting with different skeletal patterns such as skeletal class 1 and skeletal class 2 jaw relationship. Methods: It was Comparative Cross-sectional study conducted in Orthodontics Department of Nishtar Institute of Dentistry for the period of six months (5th Mar 2020 to 6th Jun 2021).  Study sample consisted of Lateral cephalometric radiographs of 65 subjects. Age range of sampled subjects was 19-26 years (mean age 20.93). The sample was divided into two groups on basis of the Skeletal jaw relationship as class-1 and class-2. An Independent t-test was applied for evaluation of the difference in lateral nasal morphology between both groups. Results:  Notable differences were found between skeletal class 1 and skeletal class 2 groups for the prominence of the mandible and Linear distance between soft tissue Pogonion and Pronasale. Considerable differences in measurements of nasal depth, nasofrontal angle, nasal tip projection angle, nasofacial angle and nasomental angle were found. Conclusions: It is concluded that nasal morphology was greatly influenced by not only the underlying skeletal jaw relationship yet other factors e.g., dentition along with soft tissue thickness were also responsible for nasal morphology differences among various skeletal patterns. Gender dimorphism also exists for various nasal features.
Assessment of Referral Patterns and Utilization of Basic Health Facilities in the Outpatient Department of a Tertiary Care Hospital: A Cross Sectional Study
Authors: Kakakhel Syed Ihtishaam , Mahmood Humaira , Khan Jawaria , Makey Gul , Arif Muhammad , Jamil Sadaf , Habib Farrukh , Raisani Sher Afgan , Shaheen Dure Yaqta , Diba Farah
Published: June 2023

The main reason behind poor healthcare delivery is malfunctioning of effective referral system. Objective: To determine the frequency of patients referred through proper channel in medical outpatient department of tertiary health care facility and to determine the causes of not utilizing basic health facilities by employing modified WHO questionnaire on Rapid Assessment of Referral Care System. A Cross-sectional descriptive study conducted in Medical Outpatient Department of Bacha Khan Medical Complex Swabi from 21st April to 21st September. Methods: Up to 400 participants going to medical outpatient department were selected through non-probability convenience sampling. Patient data like socio-demographic variables and questions with respect to referral was documented using a modified version of the Rapid Assessment of Referral Care System questionnaire from the World Health Organization. Percentages and frequencies were computed. Results: Amongst 400 participants who were included in the study, 244(61%) were female participants. About 365(91.3%) participants came to tertiary care hospital while (35) (8.8%) participants were referred. About 79(19.8%) participants were having chronic illness like Diabetes, hypertension, COPD, IHD, Asthma etc. 166(41.5%) participants choose this government facility due to presence of experienced doctors here in this facility. 159(39.8%) participants choose this facility due to presence of better care in this facility. Rest of them 75(18.7%) had other reasons. Conclusions: Most of the patients visited tertiary care hospital directly, with very minor health issues, not utilizing health facilities at the primary and secondary levels of care are overworked, which affects tertiary care facilities.
Prevalence and Determinants of Tobacco Use in the Undergraduate Students of Nursing in Peshawar, KP
Authors: Munir Bakht , Karim Hassan , Rehman Wahid ur , Bano Nasim , Khadija Bibi  , Saeed Moneeda
Published: June 2023

The plants of tobacco contain habit-forming chemical substances known as nicotine. Tobacco products are available in different forms like Smoke Tobacco (ST) and Smokeless tobacco (SLT). Common STs are cigarette, pipe tobacco (hookah), cigar, and e-cigarette. Objective: To find the prevalence and determinants of tobacco use among undergraduate nursing students. Methods: A quantitative, cross-sectional descriptive study was carried out among undergraduate nursing students. The convenient sampling technique was adopted. The sample size was calculated by Raosoft software with a known population of 1800, having a margin of error of 5%, a confidence interval of 95%, and a calculated sample size of 317. Results: Majority of the participants in this study were Male, out of total 317 participants, 135 (42.6%) of the participants, (male 51.4% and female 23.8% used tobacco) while 174 (54.9%) never tried to use tobacco. Among the tobacco users (135)25.9% smoked tobacco only (male, 31.6%: female, 14.3%), 4.1% used naswar only (male, 6.1%: female, 0%), and 5.4% (male, 6.6%: female, 1.9%) of the participants used both cigarette and naswar, and 6.9% (male, 7.1: 6.7%) of the participants used other forms of tobacco products. Conclusions: In conclusion, it was found that tobacco use among nursing students of different colleges in Peshawar is common. Male students are more prone to become users because of family members, friends and college fellows’ behaviors. Most of them tried in the age of 10 to 20 years.
Use of Physics Forcep Versus Conventional Forcep in Extraction of Mandibular First Molar
Authors: Benazeer  , Irshad Farah , Qadir Khan Usman , Memon Zunair Akbar , Kumar Punjabi Suneel , Ali Zaidi Syed Aijaz
Published: June 2023

Dental extractions are common. Atraumatic extractions utilizing various technologies are said to protect paradental structures. The new physics forceps can extract the teeth without stress. Objective: To compare the efficacy of physics versus conventional forcep in extraction of mandibular first molar. Methods: Patients aged 18 t0 40 requiring extraction of mandibular first molar were included in the study. The efficacy of extraction was evaluated based on bone loss, soft tissue tear, time required for extraction, postoperative pains, and root fracture. The participants were divided into two groups (Physics forcep and conventional forcep) using block randomization technique, and the pain and time between both groups were compared using independent samples t-test. Results: The two groups had a mean age of 2.85 ± 0.355 years. Physics Forceps (n=1, 6.7%) caused less soft tissue tears than Conventional Forceps (n=14, 93.3%) (p=0.01). 55.5% of the Physics Forceps group and 44.5% of the Conventional Forceps group took more than 10 minutes to extract (p=0.045). Physics Forceps had a greater rate of complete success (p=0.043) than Conventional forceps (p=0.043). In terms of overall instrument utility, physics forceps scored better than Conventional forces in both good and average scores (p=0.021). The difference in mean pain score in the two groups was statistically significant (p=0.0018) at day 3 and day 7 (p=0.0001) being lower in physic forcep. Conclusions: Physics forceps are a more favorable substitute to traditional forceps for atraumatic tooth extraction.
Frequency of diabetes mellitus in patients with chronic Hepatitis C Infection
Authors: Nizamuddin . , Ghaffar Tahir , Kanwal Shaista , Jan Bakhti , Aamir Muhammad Salman , Haq Tanveer ul , Rahman Adnan , Ali Muhammad
Published: June 2023

Diabetes and hepatitis C infection are prevalent worldwide. The one chronic disease the later communicable disease is associated as far mortality is concern. People with hepatitis C infection are prone to develop type 2 diabetes. Objective: To find out the frequency of diabetes mellitus in chronic hepatitis C infected patients admitted to Department of Medicine, Khyber Teaching Hospital KPK. Methods: A cross-sectional Descriptive Study was conducted having 104 patients aged 15 years and above from both genders in department of Medicine for a duration of one year from 2nd March 2020 to 26th February 2021.The inclusion criteria were set for patients who were hepatitis C positive for at least two months investigated through detection of HCV antibodies by ELISA. Chronic hepatitis C was diagnosed on the basis of detecting HCV antibodies by ELISA, and confirmed by detecting HCV RNA by polymerase chain reaction (PCR). Diabetes mellitus was diagnosed on the basis of random blood sugar above 200 mg/dL, fasting blood sugar above 126 mg/dL on two occasions or HBA1C above 6.5 % (diagnostic criteria designed by ADA). Results: Only 21 (21%) were found to have newly diagnosed diabetes mellitus with a p value 0.37. Those with impaired glucose levels were found in 15(15%), and 59(59%) were with normal glucose level. Conclusions: Our study did not find any statistical significance in our result with p-value= (0.37).
Linear and Angular Mandibular Measurements: Comparison Between Panoramic Radiography (Orthopentomogram) And Lateral Cephalogram
Authors: Khalid Asia , Awaisi Zubair H
Published: June 2023

Invention of lateral cephalogram by Hofrath in Germany and Broadbent in United States provided a clinical tool for assessment of skeletal disparities. But lateral cephalogram is not effective in measuring bilateral cranial structures independently. In orthodontic practice, panoramic radiographs are frequently obtained for information about maturation period of teeth with surrounding tissues and their axial inclination. Objective: To determine the use of orthopantomogram, whether it’s a substitute of lateral cephalogram for the linear and angular measurement of mandible. Methods: This was a Prospective Cohort study. Study was conducted at Nishtar Institute of Dentistry, Multan form January 2021 to December 2021 in one year duration. A total of 75 patients were found to be eligible for the study. Gonial angle of patients with malocclusion type I was measured with lateral cephalogram and orthopantomogram. In orthopantomogram, measurement of gonial angle was made by drawing a tangent line to the lower border of mandible and other tangent line to the distal border of ramus and both sides of condyle. In lateral cephalogram it was measured at intersection point of mandibular plane and ramus plane. Results: Overall, 75 patients were included in our study. The average age of the patients was 16.43±4.06 years. The mean difference between cephalogram and OPG was statistically significant, (p<0.001). Conclusions: Gonial angle can be measured on OPG as accurately as on lateral cephalogram but linear measurements are taken accurately by the help of orthopentomogram.