bluuebunny/crossref_metadata_2025 huggingface dataset:
A psychometric evaluation of the tripartite attachment battery
Authors: McWilliams Lachlan A. , Coveney Ashley
Published: June 2022

The Tripartite Attachment Battery (TAB) includes scales assessing attachment security, organized insecurity (i.e., anxiety and avoidance), and disorganized attachment. This recently developed series of measures provides expanded options for assessing attachment characteristics (e.g., a scale that directly assesses attachment security) and may improve the assessment of attachment anxiety and avoidance by including items capturing the secondary attachment strategies associated with them (viz., hyperactivation and deactivation). The present study utilized a community sample (N = 386) to evaluate and refine these scales. Factor analyses were conducted to: (a) examine the dimensionality of each TAB scale, and (b) guide the creation of empirically-derived subscales. The Secure Attachment Scale and the Organized Insecurity Scale were multidimensional. The Disorganized Attachment Scale was unidimensional. Most of the empirically-derived measures had internal consistency and test-retest reliability levels in the range considered adequate or better. Their correlations with a measure of psychopathology provided preliminary support for their construct validity. The TAB scales are promising measures of adult attachment characteristics. Further investigation of their psychometric properties is warranted.
MICRO-COMPUTED TOMOGRAPHIC EVALUATION OF DENTINAL CRACKS CAUSED BY VARIOUS RECENT FILE SYSTEMS
Authors: ZAN Recai , ALTUNBAŞ Demet , HUBBEZOĞLU İhsan , TOPÇUOĞLU Hüseyin , KUTLU CENGİZ Gizem
Published: June 2022

Objectives: The purpose of present study was to evaluate the incidence of dentinal micro-cracks observed after the use of ProTaper Gold (PTG), WaveOne Gold (WOG), OneShape New Generation (OSNG), K3XF nickel-titanium (NiTi) instrumentation systems.

Materials and Methods: Sixty extracted human mandibular first molars were randomly assigned to four groups (n = 15). The root canals were instrumented with PTG, WOG, OSNG, and K3XF systems. The cross-sectional images of the roots were screened using high-resolution micro-computed tomography imaging before and after preparation to detect the presence of dentinal cracks.

Results: Although there was no statistically significant difference between PTG and WOG systems, WOG caused lesser micro-crack among all groups. K3XF showed statistically fewer cracks than OSNG. K3XF and OSNG systems caused statistically more dentinal micro-cracks than both Gold systems. WOG and PTG systems caused lesser micro-cracks formation among the systems evaluated in present study. Both Gold systems may be preferred as safer to minimize micro-cracks during root canal treatments.

Conclusions: All used systems have caused different degrees of crack formations. Furthermore, WOG and PTG systems have shown superior features in terms of creating dentinal cracks according to OSNG, and K3XF systems.
SHEAR BOND STRENGTH OF CHAIRSIDE CAD-CAM BLOCKS TO ERODED DENTIN
Authors: NAİBOĞLU Pınar , SERİN KALAY Tuğba , AYDOĞAN AYAZ Elif
Published: June 2022

Objectives: To assess the shear bond strength (SBS) of chairside computer-aided design and computer-aided manufacturing (CAD-CAM) blocks to dentin subjected to simulated gastric erosion when cemented with self-etch and self-adhesive resin cements.

Materials and Methods: One hundred eighty dentin samples were assigned to two groups: sound and eroded dentin. In the eroded dentin group, samples were eroded with HCl (0.01 M, pH 2, 2 min) and stored in artificial saliva for 60 min then, brushed using a power brush (2N, 15 s). This cycle was repeated three times. CAD-CAM blocks (3x3x3 mm3, n=15/group) of Lava Ultimate (LU), Vita Enamic (VE), and Vita Suprinity (VS) were cemented to sound and eroded dentin with self-etch Multilink N (MN) and self-adhesive RelyX U200 Automix (RU) resin cements. SBS was measured after 24 hours. The failure mode was assessed by using a stereomicroscope. Data was analyzed with 3-way ANOVA and Bonferroni correction (p˂0.05).

Results: The SBS was significantly affected by the main factors: tooth structure (p=0.011), resin cements (p˂0.001), and CAD-CAM blocks (p=0.001). When LU was cemented with RU to sound dentin, a higher SBS was obtained compared to eroded dentin (p=0.001). MN revealed significantly higher SBS than RU (p
ASSESSMENT OF DMFT INDEXES, SALIVARY FLOW RATE, PH, AND DETECTIONS OF S.MUTANS SALIVARY LEVELS BY A QUANTITATIVE REAL-TIME PCR IN POLYCYSTIC OVARY SYNDROME
Authors: YENİÇERİ HİLALOĞLU N. Ezgi , GURSEL SURMELİOGLU Derya
Published: June 2022

Objectives: PCOS is an endocrine disorder that is common in women. However, PCOS effects on oral and dental health have not been stated clearly. The aim of this study is to examine the effects of Polycystic Ovary Syndrome (PCOS), which is common in women of reproductive age, on saliva and dental tissues in these women.

Materials and Methods: One-hundred individuals who were / were not diagnosed with PCOS and insulin resistance were included in this study (n=100). Subsequently, individuals, with PCOS and insulin resistance (PCOSID +), with PCOS and non-insulin resistance (PCOSID-), without PCOS and insulin resistance (ControlID +) and without PCOS and non-insulin resistance (ControlID-) were divided into 4 groups (n=25). DMFT (Decayed, Missing, Filled Teeth) index was used for dental health evaluation, while pH meter was used for saliva pH measurement. Also, Streptococcus Mutans (S. Mutans) numbers were analyzed by the real-time Polymerase Chain Reaction (PCR) method. In statistical analysis p
COVID-19 VACCINATION AND DENTISTRY: ARE WE FACING NEW CHALLENGES OR WORKING WITHIN OUR POSSIBILITIES? ANALYTICAL REVIEW
Authors: GONCHARUK Myroslav , POHORİLYAK Renata , STETSYK Mariia , LEİTE CAVALCANTİ Alessandro , YAVUZ Yasemin , PASİCHNYK Maryana
Published: June 2022

Objective. To systematize available data regarding COVID-19 vaccination aspects among dental specialists and highlight relevant occupationally-related features of vaccination challenges.

Materials and Methods. Search of pertinent literature sources associated with above-formulated objective was provided via PubMed Central database (https://www.ncbi.nlm.nih.gov/) and Google Scholar search engine (https://scholar.google.com/). Criteria of publication date included 2020-2021 years period. Publications in English or at least with English abstract/summary were collected within primary sample for further preliminary content-analysis. All articles collected for in-depth content-analysis were evaluated due to the text-mining, text-identification and text-extraction principles with further clusterization and systematization of outcomes at the Microsoft Excel 2019 software (Microsoft Office, 2019).

Results. After full reading of articles’ texts 24 of them were interpreted as those containing new and/or unique information, interpretations or facts, out of which 9 were cross-sectional online surveys, 4 were editorials, 6 were literature/clinical reviews, 1 was brief report, 1 was opinion article, 1 was ethical moment, 1 was advice article, and 1 was web-source. New challenges related with COVID-19 vaccination within dental filed are represented by personal hesitancy of dental professionals and students, which in turn associated with provided information support, previous COVID-19 experience, fear of getting infected or transmit disease to the patients or family members, fear of potential development for post-vaccination side-effects, changes of occupational status, and interaction within dental team.

Conclusions. Further improvement of dental care field possible only after vaccination of dental professionals. Vaccination of dentists widening window of their possibilities regarding potential role of dental specialist as members of COVID-19 vaccine’s delivery team, improvement of quality of life among dental patients (after its decreasing changes during pandemic), and providing dentists with important role in so-called “behaviorally informed strategies” and public motivational programs aimed at amplification of positive willingness for COVID-19 vaccination among general public.
EFFECT OF ANTI-HALITOSIS-MOUTH RINSES ON SURFACE PROPERTIES OF RESIN BASED RESTORATIVE DENTAL MATERIALS
Authors: BERKMAN Meriç , ALTUNTAŞ Ezgi , TUNCER Safa , KARABAY Ferda , DEMİRCİ Mustafa , TEKÇE Neslihan
Published: June 2022

Objectives: This in-vitro study aimed to investigate the effect of five different types of mouth rinses used for halitosis on color stability and surface roughness of two types of restorative materials. Materials and Methods: In this study, a total of 120 disc-shaped samples (10x2mm) were prepared with nano-hybrid resin composite (Filtek Z550) and giomer (Beautifill II) materials. Randomly selected samples were divided into six groups as five different mouth rinses (Listerine Fresh Burst, Listerine Total Care, Colgate Plax, Oderol, Halitosil) and a control group (distilled water). Initial color values were measured by spectrophotometer (Easyshade Compact) according to the CIELAB system, and roughness values (Ra) were measured by contact profilometer (Surtronic 25). All specimens were incubated in mouth rinses at 37° C for 12 hours and measurements were performed in the same procedure. Data were analyzed by using Kruskal-Wallis H and Bonferroni Post Hoc tests with the SPSS 24.0 program at a significance level of 0.05. Results: The results of this study showed that there was not a statistically significant increase in surface roughness values. There was a significant change in CIELAB values in all of the Beautifil II materials after the immersion in mouth rinses (P<0.05). There was a statistically significant difference between the color change values of Beautifil II and Filtek Z550 materials kept in the same mouth rinses (P<0.05). Beautifil II was exhibited color change with values above the clinically acceptable limit (ΔE>3.3). Conclusions: Color changes occurred in both of the restorative materials kept in different mouth rinses.
Bivirkninger ved en psyko- social psykiatri-kritik
Authors: Johansen Katrine Schepelern , Larsen Jonathan Led , Düring Signe
Published: June 2022

Selvom en stærk strømning, med afsæt i bl.a. psykologi, sociologi og antropologi, diskuterer og udfordrer psykiatriens vidensgrundlag og dens praksisser, lykkes det sjældent at etablere en frugtbar dialog mellem kritikerne og psykiatrien, som leder til forandring. Med andre ord fører kritikken ofte til polarisering og ikke til konstruktiv udvikling. Der er forskellige måder at forstå dette på. Enten har den psykosociale kritik ikke noget meningsfuldt eller konstruktivt at bidrage med til klinisk praksis, hvorfor den med rette bliver afvist. Eller også sker der et sammenbrud i dialogen, som i det mindste delvist kan forebygges. Vi foku- serer på den sidste mulighed. Med afsæt i eksempler taget fra to af forfatternes egne tekster diskuterer vi disse forsøg på kritik af psykiatrien. Som alternativ diskuteres, med inddra- gelse af en biopsykosocial model, hvordan fremtidens tværfaglige dialog kan udspilles mere konstruktivt. Med afsæt i fire personlige artikler om at ændre perspektiv på et vigtigt aspekt af psykiatrien, foreslås afslutningsvis hvilke dyder, der kan hjælpe en positiv udvikling mod en rigere psykiatrisk praksis på vej - et mål som deles af mange blandt såvel psykiatriens praktikere som dens kritikere.
Scalp reconstruction using the reverse temporalis muscle flap: a case report
Authors: Na Youngsu , Shin Donghyeok , Choi Hyungon , Kim Jeenam , Lee Myungchul
Published: June 2022

The scalp is the thickest skin in the body and protects the intracranial structures. The coverage of a large scalp defect is a difficult surgical procedure, the full details of which must be considered prior to the procedure, such as defect size and depth, and various factors related to the patient’s general condition. Although a free flap is the recommended surgical procedure to cover large scalp defects, it is a high-risk operation that is not appropriate for all patients. As such, other surgical options must be explored. We present the case of a patient with an ulcer on the scalp after wide excision and split-thickness skin graft for squamous cell cancer. We successfully performed a reverse temporalis muscle flap for this patient.
Yapay Zeka Algoritmalarında Kullanılan Tahmin Metotları ile Çimento ve Betonunun Basınç Dayanımına Etki Eden Faktörlerin İncelenmesi
Authors: TÜMAY ATEŞ Kübra
Published: June 2022

Artan nüfusla birlikte konut veya yapılara duyulan ihtiyaç artmıştır. Bu da bu sektörün çekirdeği olan çimento ve beton ihtiyaçlarının artmasına sebep olmuştur. Ancak çimento veya betonu oluşturan bileşenlerin içeriğinin değişmesi ya da üretimde oluşabilecek herhangi bir aksaklık durumunda nihai ürünlerin de eksik veya hatalı üretilmesine sebebiyet verebilmektedir. Aynı zamanda çimento veya beton üretiminde, bileşenlerin karışım oranlarının belirlenmesi betonun basınç dayanımını ölçebilmeyi zorunlu kılmaktadır. Bu kapsamda, nihai ürün olan beton veya çimentonun basınç dayanımının ölçülmesi sektörel olarak kaçınılmaz bir durum haline gelmiştir. Bu durum da fabrikalardaki dayanım testlerinin belirli zaman aralıkları ile ölçülmesi ile mümkündür. Nihai ürünlerin üretilmesi aşamasında zamanı verimli kullanabilmek adına yapılmış olan bu çalışmada; çimento veya betonun basınç dayanımının tahminlemesi ve bunları oluşturan bileşen miktarlarının da basınç dayanımına olan etkisi uzun yıllardır incelenen ve çalışılan konular arasında yer almaktadır. Buradan yola çıkılarak yapay zeka ile yapılmış geniş bir literatür taraması neticesinde elde edilen bulgular iki farklı başlık altında incelenmiş ve sonuçlar yorumlanmıştır.
Tedarik Zinciri Yönetiminde Lojistik ve Dağıtım Ağının Etki Seviyelerinin Belirlenmesi ve Tedarikçi Seçimi Optimizasyonu için AHP ve Matematik Programlama Modelini İçeren Yeni Bir Yaklaşım
Authors: GÜLTEPE Merve , YILMAZ Ebru
Published: June 2022

Bu çalışmada, ilk olarak, analitik hiyerarşi prosesi (AHP) yöntemi kullanılarak tedarik zinciri yönetiminde lojistik ve dağıtım ağı açısından etkisi olan kriterlerin değerlendirilmesi yapılmaktadır. Bu değerlendirme neticesinde sisteme etkisi en çok olan ana kriter ve alt kriterler belirlenmektedir. Değerlendirme neticesinde hız ana kriteri ele alınmaktadır. Daha sonra, hız kriteri ve dolayısıyla alt kriterleri de kullanılarak bir matematik programlama modeli geliştirilmektedir. Geliştirilen bu modelin çözümünde GAMS optimizasyon yazılımı kullanılmaktadır. Bu çalışmada, geliştirilen bir tedarikçi seçim probleminde, etki eden alt kriterler ve geliştirilen matematik programlama modeli kullanılarak optimum tedarikçi seçimi sağlanmaktadır.
Computational Examination of Unsteady Cavitating Flow Characteristics on a 2D NACA66 Profile by Utilizing OpenFOAM®
Authors: OĞUR Samir Arda , ALPMAN Emre
Published: June 2022

The complexity of the flow mechanism is one of the crucial problems in cavitation. In this present study, detailed computational examinations of cavitating flow around a NACA66 hydrofoil were performed by using OpenFOAM® software. Dynamic and unsteady behaviours of cavitating flow were solved utilizing the k-ω SST turbulence model. Schnerr-Sauer cavitation model was used for the calculations. Numerical simulations were performed for 6° and 8° angle of attack with different cavitation numbers and the outlet pressure conditions, the cases are called “Case 1” and “Case 2” respectively. The results were compared with the studies performed by Leroux et. al. Oscillation cycles and flow characteristics were obtained successfully in both cases. The mechanism called the re-entrant jet was shown to be primarily responsible for cavitation break-off in two cases. This mechanism consists of two steps: 1) an interplay between the re-entrant flow and the cavity contact surface in the occlusion region, resulting in recurrent secondary cloud shedding until the primary cloud detachment, and 2) a shock wave triggered by the primary cloud collapsing, which affects the development of the remnant cavity.

The main contribution of this study is to examine the impact of using the k-ω SST turbulence model with the Schnerr-Sauer cavitation model on predicting flow characteristics such as cavitation dynamics, pressure distribution and cavity form. Acceptable accuracy has been observed for pressure fluctuations and cavitation dynamics.
Yapıların Yüksek Doğruluklu Modal Analizi İçin Otomatik Darbe Tahrik Sistemi
Authors: BEDİZ Bekir
Published: June 2022

Titreşim testi yapıların dinamik davranışlarının bulunmasında veya oluşturulan modellerin doğrulanmasında kullanılan bir yöntemdir. Literatürde kullanım kolaylığı ve hızlı uygulanabilirliğinden dolayı en yaygın olarak darbe testinden yararlanılmaktadır. Bu testte yapıya ucunda bir kuvvet algılayıcısı olan bir darbe çekici ile kuvvet iletimi yapılmaktadır. Sistem dinamiklerinin doğru olarak elde edilmesi için darbenin kalitesi ve yinelenebilirliği büyük bir önem taşımaktadır. Bu çalışmada, yapıların/parçaların titreşim testlerinde kullanılmak üzere yeni otomatik bir darbe tahrik sistemi geliştirilmiştir. Bu kapsamda, özel yapım bir esnek darbe mekanizmasına bir kuvvet algılayıcısı bağlanarak kuvvet ölçümlerinin yapılması sağlanmıştır. Sistem otomasyonunun sağlanması amacıyla esnek darbe mekanizmasını belirli bir başlangıç konumuna getirecek elektromıknatıs tabanlı bir sistem entegrasyonu gerçekleştirilmiştir. Uygun darbe için gerekli kontrol parametrelerinin elde edilebilmesi için tasarlanan mekanizma modellenmiş ve ayrıca her darbe sonucu test yapısının dinamiklerinin de hesaba katılabileceği bir simülasyon alt yapısı hazırlanmıştır. Çalışma kapsamında üretilen darbe tahrik sisteminin ve otomasyon yazılımın performansları yapılan testler ile sunulmuştur.
The Swept Volume of a Circular Paraboloid End Mill Moving Along a Helical Path
Authors: DOĞRUSADIK Ahmet
Published: June 2022

To obtain complex part geometries at one pass using machining processes, it is important to employ the tools with non-conventional geometries. A circular paraboloid is a solid of revolution, which can be obtained by rotating a parabola. The swept volume of an end mill can be defined as the unification of all sets of points on the tool for every instant as it moves, and its derivation is an obligation to determine the machined part geometry prior to an actual machining process. After derivation of the swept volume of the tool, machined part geometry is obtained by subtracting the swept volume of the tool from the volume of the initial workpiece. However, derivation of the swept volume of the tool is not a straightforward task. In this work, an analytical model was introduced to derive a complete set of points on the machined part by means of well-defined and constrained tool geometry and tool path. In the model, a plane that passes through the screw axis was used to observe the instant cross-section of the tool as it moves along the helical path. By overlapping the instant cross-sections of the tool in the plane, the final cross-section was derived. Since all cross-sections that pass through the screw axis are identical, the method gives an entire set of points on the machined surface. To validate the model, a computer-aided design program was utilized.
The impact of the COVID-19 pandemic on the air quality (PM10) in Şile district of İstanbul, Turkey
Authors: ÖZVEREN Uğur , YAKIŞIK Halime
Published: June 2022

The first COVID-19 case in Turkey was approved on March 11, 2020. Based on the rapid spread feature of the Covid-19 pandemic, a partial lockdown was put into practice in the whole of İstanbul for weekends from 21st March to 1st June 2020 by the Government. The application of strict restriction precautions enabled to decrease the effect of the Covid-19 pandemic on the Turkey National Health System while changing the social behaviors. On the other hand, these forced measures provided an opportunity to determine the impact of anthropogenic events on air quality based on controlling pollution levels. The main goal of the present study is to examine the effect of the partial lockdown precautions on the pattern of air quality in the Şile district of İstanbul. The analysis of the air quality was carried out with the aid of air quality data of the monitoring station in Şile that contains PM10 concentration. The results showed that an increase of approximately 16.90% in PM10 concentrations of Şile. This was ascribed with the increment of vehicle traffic due to the migration from other districts of İstanbul during the COVID-19 outbreak. This study presents useful supplements to indicate that the application of severe execution of air pollution control plans can heal the air quality.
Ticari Otobüs Gövde Yapısında Topoloji Optimizasyonu Çalışması
Authors: KARAMERT Soner , DEMİR Abdullah
Published: June 2022

Son yıllarda otomotiv sektöründe çevreci uygulamaları destekleyen hibrit, elektrikli ve yakıt hücreli taşıtlar trendi gelişirken; bu trendler ağırlık ve maliyet azaltma ile performans ve yakıt ekonomisini iyileştirme gibi tamamlayıcı uygulamalarla desteklenmektedir. Güvenlik zafiyeti oluşturmadan yapılacak olan optimizasyon çalışmaları, araçları en uygun tasarım aşamasına getirme gayesiyle yürütülmektedir. Bu bağlamda ticari araçlarda optimizasyon çalışmaları son dönemlerde ön plana çıkmaktadır. Bu çalışmada, ticari bir otobüs gövde yapısında topoloji optimizasyonu tekniği kullanılarak optimizasyon çalışması yapılmıştır. Bir ticari taşıtın gövdesinin yol koşullarındaki mukavemetini değerlendirmenin birçok yöntemi bulunmaktadır. Bu yöntemlerden en kapsayıcısı olduğu değerlendirilen gövde katılık değerleri, optimizasyon çalışmasında kriter olarak kabul edilmiştir. Optimizasyon uygulamaları neticelendirildiğinde elde edilen otobüs gövde yapısının katılık değerleri, literatürde yer alan çalışmalardan edinilen ideal katılık değerleri, optimizasyon uygulamaları yapılmadan önceki otobüs gövdesinin burulma katılığı değerleri ile hafifletme yüzdesi, karşılaştırmalı olarak incelenmiştir. Optimizasyon çalışmaları neticesinde otobüs gövde yapısında %9 mertebelerinde bir hafifletme gerçekleştirilmiştir.
A familial case report of pili torti, pili annulati, and trichorrhexis nodosa showing autosomal dominant inheritance with microscopic findings
Authors: Prasad Vijeta , Mohta Alpana , Soni Prasoon , Pareek Sumiti
Published: June 2022

Hair shaft disorders encompass a wide range of hair shaft defects with or without fragility, which could be acquired or inherited genetically. Hair shaft defects may be localized or generalized and are characterized by changes in color, structure, length, and density. Pili torti, also called twisted hair, is a clinical entity in which the hair shaft is flattened and twisted by 180° along its axis. Pili annulati is described as striped hair, showing alternate light and dark bands. Trichorrhexis nodosa is the fracture of the hair shaft. Pili annulati and trichorrhexis nodosa has been reported in a single patient. Herein, we report a familial case of pili torti, pili annulati, and trichorrhexis nodosa with autosomal dominant inheritance.
Serum lipide profile and the severity of acne vulgaris at a Moroccan referral hospital
Authors: Kerrouch Hasna , El Bakali El Khalil , Frikh Rachid , Hjira Naoufal , Boui Mohammed
Published: June 2022

Sir, Acne vulgaris (AV) is one of the most frequent concerns in dermatology consultation. It is an inflammatory chronic condition that affects the pilosebaceous follicle. Based on the number and types of lesions, AV is classified as mild, moderate, severe, and highly severe [1]. The pathogenesis of AV is due to multiple factors, such as sebum overproduction, inflammation, colonization by Propionibacterium acnes, hyperkeratinization, the genetic component, and stress [2–4]. It is known that the sebaceous glands produce and secret sebum, which is a combination of complex lipids, such as squalene, triglycerides, wax, and cholesterol, as well as free cholesterol and fatty acids [5]. A number of studies evaluated the relationship between acne vulgaris and the serum lipid profile. Therefore, the aim of our study was to analyze the lipid serum profile among Moroccan patients with acne. We prospectively conducted a study between June 2020 and December 2021 at the Mohammed V Military Hospital in Rabat, Morocco. The criteria for inclusion in the study were AV patients aged from thirteen to thirty years. The exclusion criteria were obesity, pregnancy and lactation, oral contraceptives, hormonal therapy, cardiovascular disease, and health conditions affecting lipid metabolism. The clinical data collected from patients included age, sex, weight, and the severity of AV. Acne grading was performed by the same dermatologist according to the Global Acne Grading System (GAGS). The patients were required to have been fasting between eight to twelve hours at the time of the blood test. Statistical analysis was performed with JAMOVI. The results were presented as follows: mean ± SD. Descriptive statistics were performed; Student’s t-test, ANOVA, and X2 were used as statistical tests to compare between variables, and p < 0.05 was considered a statistically significant difference.
Acral purpura and pityriasis rosea-like eruption following COVID-19 infection
Authors: Klimi Eleni , Vasdeki Dionysia
Published: June 2022

Sir, A 74-year-old female patient treated with angiotensin-converting enzyme inhibitor for arterial hypertension with metformin and atorvastatin for insulin-independent diabetes mellitus and hyperlipidemia, respectively, consulted the outpatient dermatological clinic for a rash that appeared fifteen days prior to consultation. The patient received the second dose of mRNA COVID-19 vaccine on July 29, 2021, and was due to receive the third dose on December 29, yet she fell ill on day 6 of the same month, probably being infected by one of her grandchildren. The eruption consisted of erythematous, purpuric macules on the anterior face of both tibia (Fig. 1a), of a solitary papule on the left hand (Fig. 1b), and of erythematous papules with a scale on the border on the left buttock (Fig. 1c). A collarette formed on the trailing edge of the advancing border of the hand lesion, a clinical sign pathognomonic of pityriasis rosea. Intense pruritus accompanied the eruption. No herald patch was observed, nor lesions on the trunk, being the typical location of lesions of pityriasis rosea, while lesions on the hands are absent in the typical cases of the disease. The oral and genital mucosae were intact. The cutaneous manifestations of COVID-19 include purpuric, chilblain, vesicular, urticarial, and pityriasis rosea-like lesions. Acral lesions are the most frequent location of the cutaneous manifestations associated with COVID-19 infection [1]. An acral distribution of lesions is a feature of mouth, hand, and foot disease due to infection with Coxsackie A16 virus [2], although no reactivation of this virus has been detected during the COVID-19 pandemic, while the reactivation of herpes 6 and herpes 7 virus associated with pityriasis rosea has occurred
Leser–Trélat syndrome and squamous cell carcinoma of the bladder
Authors: Lenga Loumingou Ida Aurélie , Diabaté Almamy , Dimi Nyanga Yannick Ijosdi
Published: June 2022

Sir, Paraneoplastic syndromes are contemporaneous with various malignant tumors. Leser–Trélat syndrome is a paraneoplastic syndrome associated with certain cancers, notably, breast, lung, kidney, hepato-digestive, melanoma, and lymphoma [1]. The pathogenesis of Leser–Trélat syndrome remains unknown. Exceptional observations associate Leser–Trélat with bladder carcinoma [2]. Herein, we report Leser–Trélat syndrome in a 75-year-old black patient with bladder carcinoma. The aim of this work is to report an unusual association. The patient was a 75-year-old male, a non-smoker, with no previous history, admitted to the urology department of the Brazzaville Hospital for bladder carcinoma. The tumor suspected on ultrasound was documented by anatomopathological examination. The incidental discovery of a rash of diffuse pigmented papules located preferentially on the trunk, consisting of lesions of variable size, measuring from 3 to 1 cm, with a soft or firm consistency and irregular surface (Fig. 1). These lesions were suggestive of seborrheic keratoses.
Delusional parasitosis as a tactile hallucination handled by dermatologists
Authors: Sharquie Khalifa Ebeid , Younis Maha Sulaiman
Published: June 2022

Background: Delusional parasitosis (DP) is a false, unshakable belief that pathogens have infested one’s own skin or body. Objective: The objective was to record all patients with DP, a rare presentation of monosymptomatic delusion, in Iraq. Patients and Methods: This was a descriptive study of 21 cases diagnosed with DP in Medical City Teaching Hospital in Baghdad, Iraq, between 2013 and 2021. A detailed history and clinical examination were conducted to exclude actual organic disease. Results: All patients were females with a mean age of 65 years. They believed strongly to have pathogens in their skin or scalp, carrying containers with samples of skin debris, fibers, dead insects, hair waste, and small stones as proofs of their infestation. Careful psychiatric assessment ruled out schizophrenia, substance use disorders, and dementia, and proved the psychiatric diagnosis of monosymptomatic delusion. The patients described their symptoms as something crawling, stinging, and biting sensations. On examination, we often saw shaved scalp hair with injured skin in the form of excoriations, ulcerations, scarring, and pyogenic infections in a localized area. Conclusion: DP is a single symptom-sign complex manifestation in a person with a well-preserved personality apart from a single tactile hallucination of some sort of pathogens infesting their skin. It is commonly a disease of the scalp of elderly females that run a chronic course and rarely remits in a short time. Proper liaison between dermatologists and psychiatrists assisted by laboratory facilities is required for diagnosis and follow-up. Empathetic rapport, psychiatric referral, and early treatment by atypical anti-psychotics significantly improve such conditions.
The role of peripheral arterial occlusive disease in the healing of venous ulcers
Authors: Vasilev Blagoja , Vasileva Mirela , Vasileva Stojka
Published: June 2022

Background: The biggest challenge in patients with chronic venous insufficiency is venous ulcers that occur in stage 6 of the CEAP classification. In general, acute ulcers have a 71–80% chance of healing, while chronic ulcers only have a 22% chance of healing. Our clinical practice has shown that patients diagnosed with peripheral arterial occlusive disease have a much longer duration of the disease and a more difficult treatment of venous ulcers than patients with normal arterial circulation. Materials and Methods: The study included 105 patients with CVI and a developed leg ulcer. Among these, twenty patients were diagnosed with peripheral arterial occlusive disease. All patients were followed for more than twelve weeks. Results: Peripheral arterial occlusive disease was significantly more common in patients with delayed healing than in patients with normal venous ulcer healing: 18 (30%) vs. 2 (4.4%). for twelve weeks or longer, and it was statistically significant for p = 0.00097. Conclusion: Peripheral arterial occlusive disease has been shown to be an important indicator of venous epithelial wound healing. The establishment of good arterial circulation is closely related to the course of treatment of chronic venous ulcers.
Modeling groundwater/surface-water interactions and their effects on hydraulic barriers, the case of the industrial area of Mantua (Italy)
Authors: Bonomi Tullia , Sartirana Davide , Toscani Luca , Stefania Gennaro A. , Zanotti Chiara , Rotiroti Marco , Redaelli Agnese , Fumagalli Letizia
Published: June 2022

The town of Mantua is a good example of an urban area with an intricate surface water system leading to complex groundwater/surface-water interactions. In this context, the Site of National Interest (SIN) “Laghi di Mantova e Polo Chimico”, is characterized by intense pumping activity by means of industrial wells and hydraulic barriers. In order to establish the interactions between groundwater and the surface water system, evaluating their relation with the pumping activities, a transient groundwater numerical model was developed (January 2016 - December 2018) using MODFLOW-2005 and the Streamflow-Routing (SFR2) package, following a participatory approach. Results show how, depending on the minimum/ maximum groundwater conditions and the discharge values of the surface channels, the relation between groundwater/surface-waters can vary during the year, also affecting the operation of the hydraulic barriers. The stakeholders could use the calibrated model in the future to ensure optimal management of the pumping activities within the SIN.
The survey of Italian springs by the National Hydrographic Service, a forgotten database. Structuring and analysis of a dataset of Campania springs (southern Italy)
Authors: Cusano Delia , Allocca Vincenzo , Coda Silvio , Lepore Daniele , Vassallo Massimiliano , De Vita Pantaleone
Published: June 2022

The analysis of groundwater resources is a particularly significant aspect of the economic, social and environmental development of the national territory. This is particularly relevant for the Campania region which, although characterized by the most significant aquifer systems of southern Italy, suffers from critical issues related to the progressive increase in demand and climatic variability at different time scales. In this framework, the lack of data concerning the survey of springs, including the minor ones, and of historical discharge measurements represents the main limitation to a more comprehensive regional hydrogeological characterization. The only source of historical data regarding the systematic and comprehensive survey of springs and discharge measurement is the Publication No. 14 of the National Hydrographic Service of the Ministry of Public Works “The Italian springs. List and description” reporting measures made between the 1920s and 1940s which was published in distinct volumes for each compartment. Despite its potential relevance, this source has so far been little used in regional hydrogeological studies. In this paper, a comparative analysis among data of springs derived from the Publication No. 14 and from measurement campaigns made by the Cassa per il Mezzogiorno (Special Project 26), between the 1960s and 1980s for main springs, was carried out for the Campania region. The information available from each source was validated through a cross-check, by means of a comparison of coordinates and a statistical analysis of the characterizing parameters. The new dataset allowed to expand the hydrogeological regional characterization with a higher number of springs, including the minor ones. The results obtained recognize the Publication No. 14 of the National Hydrographic Service as an important source of data to not be overlooked, especially in a condition of historical data shortage, by which can be both carried out regional hydrogeological and temporal analyses as well as identified integrative groundwater resources.
The strong 3-rainbow index of some certain graphs and its amalgamation
Authors: Awanis Zata Yumni , Salman A.N.M.
Published: June 2022

We introduce a strong \(k\)-rainbow index of graphs as modification of well-known \(k\)-rainbow index of graphs. A tree in an edge-colored connected graph \(G\), where adjacent edge may be colored the same, is a rainbow tree if all of its edges have distinct colors. Let \(k\) be an integer with \(2\leq k\leq n\). The strong \(k\)-rainbow index of \(G\), denoted by \(srx_k(G)\), is the minimum number of colors needed in an edge-coloring of \(G\) so that every \(k\) vertices of \(G\) is connected by a rainbow tree with minimum size. We focus on \(k=3\). We determine the strong \(3\)-rainbow index of some certain graphs. We also provide a sharp upper bound for the strong \(3\)-rainbow index of amalgamation of graphs. Additionally, we determine the exact values of the strong \(3\)-rainbow index of amalgamation of some graphs.
Nordhaus-Gaddum bounds for upper total domination
Authors: Haynes Teresa W. , Henning Michael A.
Published: June 2022

A set \(S\) of vertices in an isolate-free graph \(G\) is a total dominating set if every vertex in \(G\) is adjacent to a vertex in \(S\). A total dominating set of \(G\) is minimal if it contains no total dominating set of \(G\) as a proper subset. The upper total domination number \(\Gamma_t(G)\) of \(G\) is the maximum cardinality of a minimal total dominating set in \(G\). We establish Nordhaus-Gaddum bounds involving the upper total domination numbers of a graph \(G\) and its complement \(\overline{G}\). We prove that if \(G\) is a graph of order \(n\) such that both \(G\) and \(\overline{G}\) are isolate-free, then \(\Gamma_t(G) + \Gamma_t(\overline{G}) \leq n + 2\) and \(\Gamma_t(G)\Gamma_t(\overline{G}) \leq \frac{1}{4}(n+2)^2\), and these bounds are tight.
Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics of Mycobacterium tuberculosis
Authors: Menardo Fabrizio
Published: June 2022

Detecting factors associated with transmission is important to understand disease epidemics, and to design effective public health measures. Clustering and terminal branch lengths (TBL) analyses are commonly applied to genomic data sets of Mycobacterium tuberculosis (MTB) to identify sub-populations with increased transmission. Here, I used a simulation-based approach to investigate what epidemiological processes influence the results of clustering and TBL analyses, and whether differences in transmission can be detected with these methods. I simulated MTB epidemics with different dynamics (latency, infectious period, transmission rate, basic reproductive number R0, sampling proportion, sampling period, and molecular clock), and found that all considered factors, except for the length of the infectious period, affect the results of clustering and TBL distributions. I show that standard interpretations of this type of analyses ignore two main caveats: (1) clustering results and TBL depend on many factors that have nothing to do with transmission, (2) clustering results and TBL do not tell anything about whether the epidemic is stable, growing, or shrinking, unless all the additional parameters that influence these metrics are known, or assumed identical between sub-populations. An important consequence is that the optimal SNP threshold for clustering depends on the epidemiological conditions, and that sub-populations with different epidemiological characteristics should not be analyzed with the same threshold. Finally, these results suggest that different clustering rates and TBL distributions, that are found consistently between different MTB lineages, are probably due to intrinsic bacterial factors, and do not indicate necessarily differences in transmission or evolutionary success.
Maintaining the joy of discovery
Authors: Marder Eve
Published: June 2022

Changes in science over the past 50 years have reduced the chances of trainees experiencing the joy of discovery.
G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice
Authors: Yun Damin , Zhou Liwei , Shi Jie , Li Xinyao , Wu Xiaolong , Sun Fei
Published: June 2022

Background

Spermatogenesis is a complex process that includes mitosis, meiosis, and spermiogenesis. During spermatogenesis, genetic factors play a vital role inthe formation of properly functioning sperm. GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) is known to take part in immune responses, mRNA transport, and stress-granule assembly. However, its role in male fertility is unclear. Here, we generated a G3bp2 conditional knockout (cKO) mouse model to explore the function of G3BP2 in male fertility.

Methods

Polymerase chain reaction (PCR) and western blotting (WB) were used to confirm testis-specific G3bp2 knockout. Hematoxylin-eosin (HE) staining to observe testicular morphology and epididymal structure. Computer-aided sperm analysis (CASA) to detect sperm concentration and motility. Terminal deoxynucleotidyl transferase-dUTP nick-end labeling (TUNEL) assay was used to detect apoptotic cells.

Results

We found that cKO male mice are fertile with the normal morphology of the testis and sperm. Additionally, CASA of the semen from cKO mice showed that they all had a similar sperm concentration and motility. In addition, sperm from these mice exhibited a similar morphology. But the tunnel assay revealed increased apoptosis in their testes relative to the level in the wild type (WT).

Conclusion

Together, our data demonstrate that G3BP2 is dispensable for spermatogenesis and male fertility in mice albeit with the increased germ-cell apoptosis.
Longitudinal study on the effect of keratinized mucosal augmentation surrounding dental implants in preventing peri-implant bone loss
Authors: Kikuchi Takeshi , Wada Masahiro , Mameno Tomoaki , Hasegawa Daisuke , Serino Giovanni , Ikebe Kazunori
Published: June 2022

Background

Dental implant therapy is a well-established method of prosthetic rehabilitation of missing teeth. To maintain the health of the surrounding tissue, management of risk factors/indicators and daily maintenance are important. It still remains controversial whether a certain amount of keratinized mucosal width is essential for maintaining the health of peri-implant tissue. The purpose of this multicenter retrospective study was to assess the correlation between bone loss around dental implant and the amount of keratinized tissue width.

Methods

A total of 1,644 implants were evaluated. Data was collected about participants’ general and dental history, as well as implant details. Bone resorption around implant was calculated from intra-oral radiographs taken after 1 year and more than 3 years of function. Implants were classified into three groups; received free gingival graft or apically repositioned flap surgery for increasing the keratinized mucosa ≥2 mm width (group A), keratinized mucosa width ≥2 mm (group B), and keratinized mucosa width <2 mm (group C). These data were analyzed by propensity score analysis and a generalized linear regression analysis was performed to compare the bone resorption among groups.

Results

Mean functional time was 55.8 months (SD = 20.5) in group A, 67.6 months (SD = 28.1) in group B, and 74.5 months (SD = 32.9) in group C. Mean bone resorption of groups A, B, and C were 0.08 mm (SD = 0.40), 0.18 mm (SD = 0.66), and 0.44 mm (SD = 0.40). Groups A and B had significantly lower bone resorption than group C.

Conclusion

The results in this study show the importance of keratinized mucosa in maintaining the peri-implant bone. Our findings also suggest that mucosal transplantation is useful, as opposed to narrowing of the keratinized mucosa.
Happiness, depression, physical activity and cognition among the middle and old-aged population in China: a conditional process analysis
Authors: Shi Xiaojuan , He Xiaoxue , Pan Degong , Qiao Hui , Li Jiangping
Published: June 2022

Background

Happiness is one variable of subjective well-being, which has been increasingly shown to have protective effects on health. Although the association between happiness and cognition has been established, the mechanism by which happiness leads to cognition remains unclear. Since happiness, depression, and physical activity may all be related to cognition, and happiness is related to depression and physical activity, this study explored the effect of depression and physical activity on the relationship between happiness and cognition among middle and old-aged individuals in China.

Methods

Data on 14,344 participants above 45 years of age were obtained from the 2018 China Family Panel Studies survey. A multiple linear regression analysis was performed to identify the correlation factors of cognition. The conditional process analysis was used to assess the mediatory effect of depression and physical activity on the relationship between happiness and cognition.

Results

Residence, age, sex, income level, social status, smoking, napping, reading, education, exercise times, satisfaction, happiness, and depression had associations with cognition. When other variables were held constant, cognition score increased by 0.029 standard deviation(SD) for every 1 SD increased in happiness. Mediation analysis showed that happiness had a significant positive total effect on cognition. The direct effect of happiness was significant and accounted for 57.86% of the total effect. The mediatory effect of depression (path of happiness→depression→cognition) accounted for 38.31% of the total effect, whereas that of physical activity (path of happiness→exercise times→cognition) accounted for 3.02% of the total effect.

Conclusion

Happiness has a positive correlation with cognitive function, and depression and physical activity play mediatory roles in this association. Effective interventions to improve happiness levels of middle and old-aged population will not only improve their subjective well-being but also improve their cognitive function, which carries great potential for reducing public health burdens related to cognitive aging.
Enhanced specialized metabolite, trichome density, and biosynthetic gene expression in Stevia rebaudiana (Bertoni) Bertoni plants inoculated with endophytic bacteria Enterobacter hormaechei
Authors: Oviedo-Pereira Dumas G. , López-Meyer Melina , Evangelista-Lozano Silvia , Sarmiento-López Luis G. , Sepúlveda-Jiménez Gabriela , Rodríguez-Monroy Mario
Published: June 2022

Stevia rebaudiana (Bertoni) Bertoni is a plant of economic interest in the food and pharmaceutical industries due its steviol glycosides (SG), which are rich in metabolites that are 300 times sweeter than sucrose. In addition, S. rebaudiana plants contain phenolic compounds and flavonoids with antioxidant activity. Endophytic bacteria promote the growth and development and modulate the metabolism of the host plant. However, little is known regarding the role of endophytic bacteria in the growth; synthesis of SG, flavonoids and phenolic compounds; and the relationship between trichome development and specialized metabolites in S. rebaudiana, which was the subject of this study. The 12 bacteria tested did not increase the growth of S. rebaudiana plants; however, the content of SG increased with inoculation with the bacteria Enterobacter hormaechei H2A3 and E. hormaechei H5A2. The SG content in leaves paralleled an increase in the density of glandular, short, and large trichome. The image analysis of S. rebaudiana leaves showed the presence of SG, phenolic compounds, and flavonoids principally in glandular and short trichomes. The increase in the transcript levels of the KO, KAH, UGT74G1, and UGT76G1 genes was related to the SG concentration in plants of S. rebaudiana inoculated with E. hormaechei H2A3 and E. hormaechei H5A2. In conclusion, inoculation with the stimulating endophytes E. hormaechei H2A3 and E. hormaechei H5A2 increased SG synthesis, flavonoid content and flavonoid accumulation in the trichomes of S. rebaudiana plants.
A Real-time Monitoring Method of Prestressed Tubular Piles Construction Based on Machine Vision
Authors: Zhang Yulong
Published: June 2022

Prestressed tubular piles are a kind of workpiece commonly used in infrastructure construction of oil and other industries. The prestressed tubular piles shall be vertical to the ground at all times during installation. In engineering practice, professionals are usually required to monitor at all times. This method is easy to lead to personnel fatigue and error. Aiming to this, in this paper, a real-time monitoring method of prestressed tubular piles construction state based on machine vision is proposed and verified with the field data. The proposed method can realize the real-time vertical monitoring of prestressed tubular piles during installation. The research results can provide a reference for the assistance and automatic monitoring of the prestressed tubular piles installation process.