bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association Between Smoking Status and Severity Degree of Diabetic Foot
Authors: Surya Nadhea Debrinita , Jonny Setiawan  , Rensa
Published: October 2020

Diabetes mellitus is a chronic metabolic disease which happens to be the 7th leading cause of death worldwide. In Indonesia, 6.9% of population aged ³ 15 years old suffers from this disease. Diabetic foot is one of the complication of diabetes mellitus which has high mortality and morbidity level. Smoking is an addictive behavior that is really common in Indonesia. Components inside a cigarette, such as nicotine, can contribute in determining the prognosis of diabetic foot through various mechanism. This study aims to investigate the association between smoking status and the severity degree of diabetic foot. This study is an observational analytic study using a cross-sectional approach. Data collection was conducted on January 2019 until July 2019 in RSUK Pesanggrahan and Atma Jaya Hospital Jakarta. The research data was obtained through interviews with diabetic foot patients and medical record reading. Data was analyzed using the chi-square method. There were 40 patients eligible to be the subject of this study. The smoker status with the most distribution was moderate smoker (27.5%) and severity degree of diabetic foot with most distribution was Wagner 3 (25%). Bivariate analysis showed that there was a significant association between smoking status and severity degree of diabetic foot (p < 0.001). In conclusion, there is a significant association between smoking status and the severity degree of diabetic foot. Therefore, education regarding the importance of smoking cessation to diabetic foot patients should be done in order to improve the prognosis of diabetic foot patients.
Prevention of domestic violence against the elderly
Authors: Володіна О. О. , Малиновська Т. М.
Published: October 2020

Domestic violence is one of the most common forms of human rights violations. Illegal actions against a family member are in most cases accompanied by acts of aggression, humiliation and abuse. Such actions by the abuser lead to a negative physical, mental and social health of the victim or several members of the family. As a rule, women, children and the elderly suffer the most from domestic violence.

The state is the main actor in combating violence, and public authorities should help to create the environment of non-violence by taking the necessary measures and creating the system of protection of victims, punishment of perpetrators and prevention of violence.

Despite the existing regulatory provision in the field of combating and protecting the rights and interests of victims of domestic violence, as well as a wide range of scientific papers focused on various aspects in this area, the problem of domestic violence remains relevant and needs theoretical clarification and justification.

The purpose of the article is to determine the causes of the origin of domestic violence against the elderly, to analyze the forms for the commission of violence against persons of this category, to focus on the wide scale of this issue, preventive measures and the need to create an information base (statistics) of victims. The introduction of an information database (statistics accounting) of victims suffered from domestic violence will ensure unimpeded access for employees of the National Police, territorial centers of social services and medical institutions to information about the victims. Inquiries and reports will make it possible to quickly and efficiently update the information and keep differentiated statistical records of such persons.
Issues of Improving the Provisions of the Current Law of Ukraine Regarding the Prevention of the Origin and Spread of COVID-19 Coronavirus Disease
Authors: Бугайчук К. Л.
Published: October 2020

The author has studied the current state of the regulatory base on the prevention of the occurrence and spread of the COVID-19coronavirus disease in Ukraine and the practice of its application by authorized entities for the implementation of state policy in the field of health care and the protection of the rights and freedoms of citizens.

The system of public administration in the field of ensuring the sanitary and epidemiological well-being of the population has been analyzed. The features of the distribution of powers of state agencies in this area after the liquidation of the State Sanitary and Epidemiological Service of Ukraine have been researched.

The author concludes that the existing system of state agencies that carry out sanitary and epidemiological control in Ukraine requires further improvement by adopting a decree of the Government of Ukraine on the functioning of the State Sanitary and Epidemiological Service. The author of the article has also identified gaps in the current legislation of Ukraine on administrative offenses, which regulates the procedure for holding accountable for violation of sanitary and anti-epidemic rules. These shortcomings primarily relate to the content of the Code of Ukraine on Administrative Offenses, which contains the names of non-existent state agencies or their officials, the provisions of repealed laws or other by-laws.

Based on the analysis of the laws of Ukraine and government decrees on the implementation of sanitary and anti-epidemiological measures, the author has formulated propositions aimed at regulating the legal status of the State Sanitary and Epidemiological Service; improvement of administrative proceedings in the field of health care and violation of quarantine rules; amending the list of agencies and officials authorized to consider cases of administrative offenses for the violation of sanitary rules; optimization of the mechanism of prosecution for failure to comply with legal orders of entities implementing the state sanitary and anti-epidemiological policy; expanding the list of powers of the National Police for the implementation of administrative detention, verification of documents and police custody within the sequestration.
Analisis Pengaruh Karakteristik Individu, Pekerjaan dan Lingkungan Kerja Terhadap Motivasi dan Kinerja Tenaga Kerja Sukarela Pengumpul Sampah
Authors: Anita Melina Febriyanti  , Ginta Ginting  , Andriyansah
Published: October 2020

The Environmental Agency of Rejang Lebong Regency is one of the Government Agencies that has assets of 277 volunteers in 2020, with 80 voluntary garbage collection workers. Human resources or voluntary workforce contribute and have an important role in the success and achievement of the agency's goals in this case the Rejang Lebong Environmental Agency. Based on data from The Hazardous and Non-Hazardous Waste Section in Rejang Lebong Environmental Agency in 2017, 2018 and 2019, the voluntary workforce of garbage collectors are able to collect waste as many as 14,999.82 tons, 15,191.71 tons and 16,230.88 tons tons or only 39.68%, 40.03%, and 42.65% of the targets planned by the Rejang Lebong Environmental Agency for 2017, 2018 and 2019 respectively 37,800 tons, 37,951.97 tons, and 38,103.78 tons. This shows that the targets achieved for 2017, 2018 and 2019 are still less than 50%. Based on the results of this research, it can be seen that there are several things that affect the motivation and performance of workers in achieving agency goals, including: job characteristics affect motivation, and individual characteristics, work environment, and motivation affect workforce performance.
COVID-19 Impact on Ride-hailing: The Chicago Case Study
Authors: Du Jianhe , Rakha Hesham A.
Published: October 2020

A dramatic traffic volume reduction has been observed worldwide and across the United States since the onset of the COVID-19 pandemic. This event provides us with a unique opportunity to investigate the changes in ride-hailing travel prior and during the pandemic and the resulting significant drop in economic activities associated with the pandemic. In this paper, we collected and analyzed trip-by-trip ride-hailing data from the City of Chicago over 6 months (January to June) in 2019 and 2020. The results from Chicago show a significantly greater decrease in the number of ride-hailing trips compared to those using personal vehicles during the pandemic. In most cases, the average travel distances lengthened while the average travel times shortened. Pooled trips decreased significantly (71%) in early March and disappeared completely on March 17 when Uber and Lyft suspended trip pooling. Short trips that used to occur within the same census tracts decreased remarkably. To our knowledge this is the first effort to analyze ride-hailing data as related to COVID-19. We hope that this effort serves as a first step towards conducting other studies in other cities.
Motivational and affective drivers of right-wing populism support: Insights from an Austrian presidential election
Authors: Lüders Adrian , Mühlberger Christina , Jonas Eva
Published: October 2020

Research has identified political disenchantment as an important driver for the recent spread of right-wing populism. The cultural backlash approach explains this relationship as a counter response to progressive socio-political developments in Western societies. Drawing on previous work, the present research examines motivational and affective factors underlying the support of right-wing populist parties. We hypothesize that a perceived alienation from the symbolic architecture of a society may decrease levels of psychological need satisfaction, which may catalyze into anxiety and anger. As the “political system” represents an important reflective surface for the socio-political status quo, we expected lower levels of need satisfaction and its resulting affective consequences to help explain the relationship between political disenchantment and right-wing populist support. We tested these tenets based on data from the 2016 Austrian presidential election (n = 626). The results of a structural equation model corroborated our predictions with some exceptions. Data indicated a negative relationship between political disenchantment and need satisfaction. Moreover, decreased need satisfaction was associated with increased self-reported anxiety and anger. Political disenchantment indirectly predicted support for a right-wing populist presidential candidate through decreased need satisfaction and anger, thus corroborating the role of anger as an important driver underlying right-wing populism support. Counterintuitively, the data indicated a negative relationship between anxiety and right-wing support. We discuss theoretical and practical implications, as well as limitations stemming from sample characteristics and the employed cross-sectional design.
Measurement of proecological attitudes within new ecological paradigm in Polish current settings
Authors: Dyr Wojciech , Prusik Monika
Published: October 2020

The NEP (New Ecological Paradigm) scale is an internationally used measure of environmental attitudes and a predictor of pro-ecological behaviours (Dunlap, Van Liere, Merting, & Jones, 2000). In the current study we investigate the factor structure of the scale in order to state if it fits the theoretical model concerning the Polish population. We use the GEB (General Ecological Behaviour) scale as a test of the convergent validity of NEP scale results. The online study made use of a convenience sample of people aged 17–68 years, N = 305. Our study revealed that the theoretical concept of the NEP scale, including its five-factorial solution proposed by the authors of the scale, does not fit our results. After having conducted the exploratory structural equation modelling (ESEM) we found a two-factorial structure to be more appropriate, but the newly revealed solution was still not completely satisfactory according to the obtained psychometric parameters. Convergent validity of NEP was confirmed. However, socio-demographic characteristics of participants in the study were not related to the frequency of pro-ecological behaviours in general.
MSC virtual e-abstract (NPP)
Authors: Stroke Conference 2020 Malaysia
Published: October 2020

Endothelin-1 induced focal ischemia in adult zebrafish: A model with novel entity of stroke research.

Poly (lactide-co-glycolide) nanoparticle encapsulating brain-derived neurotrophic factor promotes neuroprotection in an acute ischemic stroke model in the rat.

Tele-consultation for augmentative and alternative communication in individuals with locked-in syndrome.

Teleneurorehabilitation during covid-19 pandemic in Malaysia.

Evaluation of oral health status and salivary parameters among stroke patients in Hospital USM, Kelantan.

The neuroprotective effect of (s)-3,5-dhpg preconditioning via down regulatory antagonist modulator (dream) in acute ischemic stroke rats.

The effects of hypothermia and p4 on glt-1 and p62 of primary cortical astrocytes following exposure to glutamate toxicity.

Assessment of awareness and action towards signs and symptoms of stroke among lay public in Kuantan, Malaysia: A cross-sectional a study.
MSC virtual e-abstract (ONC)
Authors: Stroke Conference 2020 Malaysia
Published: October 2020

Incidence rate of developing first ever stroke over a 5-year period.

Post-stroke aphasia rehabilitation in Malaysia: findings from a survey with speech-language pathologists.

Neuroprotective effect of nanoparticle-bounded brain-derived neurotrophic factor (bdnf) on experimental haemorrhagic stroke in rats.

Adenosine a1 receptor plays role in neuroprotection by resveratrol against neurobehavioural deficits in rat model of hemorrhagic stroke.
Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria
Authors: Risitano Antonio M. , Kulasekararaj Austin G. , Lee Jong Wook , Maciejewski Jaroslaw P. , Notaro Rosario , Brodsky Robert , Huang Mingjun , Geffner Michael , Browett Peter
Published: October 2020

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes. Danicopan is a first-in-class oral proximal, complement alternative pathway factor D inhibitor. Therapeutic factor D inhibition was designed to control intravascular hemolysis and prevent C3-mediated extravascular hemolysis. In this open-label, phase II, dose-finding trial, ten untreated PNH patients with hemolysis received danicopan monotherapy (100-200 mg thrice daily). Endpoints included changes in the concentrations of lactate dehydrogenase (LDH) at day 28 (primary endpoint), of LDH at day 84, and of hemoglobin. Safety, pharmacokinetics/ pharmacodynamics, and patient-reported outcomes were assessed. Ten patients reached the primary endpoint; two later discontinued treatment: one because of a serious adverse event (elevated aspartate aminotransferase/ alanine aminotransferase coincident with breakthrough hemolysis, resolving without sequelae) and one for personal reasons unrelated to safety. Eight patients completed treatment. Intravascular hemolysis was inhibited, as demonstrated by a mean decrease of LDH (5.7 times upper limit of normal [ULN] at baseline vs. 1.8 times ULN at day 28 and 2.2 times ULN at day 84; both P<0.001). Mean baseline hemoglobin, 9.8 g/dL, increased by 1.1 (day 28) and 1.7 (day 84) g/dL (both P<0.005). No significant C3 fragment deposition occurred on glycosylphosphatidylinositol- deficient erythrocytes. Mean baseline Functional Assessment of Chronic Illness Therapy–Fatigue score, 34, increased by 9 (day 28) and 13 (day 84) points. The most common adverse events were headache and upper respiratory tract infection. These phase II, monotherapy data show that proximal inhibition with danicopan provides clinically meaningful inhibition of intravascular hemolysis and increases hemoglobin concentration in untreated PNH patients, without evidence of C3-mediated extravascular hemolysis. This trial was registered at www.clinicaltrials.gov (#NCT03053102).
РОЗРОБЛЕННЯ МОБІЛЬНИХ ДОДАТКІВ ДОПОВНЕНОЇ РЕАЛЬНОСТІ ДЛЯ ВИВЧЕННЯ ТРИВИМІРНИХ МОДЕЛЕЙ ІЗ ІНЖЕНЕРНОЇ ГРАФІКИ
Authors: Канівець Олександр Васильович , Канівець Ірина Михайлівна , Кононец Наталія Василівна , Горда Тетяна Михайлівна
Published: October 2020

Автори актуалізують проблему реалізації мобільного навчання студентів у межах упровадження концепції ресурсно-орієнтованого навчання у вищій школі. На основі аналізу досліджень зроблено висновок про те, що мобільне навчання тлумачиться як форма ресурсно орієнтованого навчання і розглядається як система організаційних і дидактичних заходів, які базуються на використанні мобільних інформаційно-комунікаційних технологій та мобільних педагогічних програмних засобів. Зазначається, що одним із напрямів реалізації концепції ресурсно орієнтованого навчання у вищій школі є розробка таких мобільних педагогічних програмних засобів, які уможливлять підвищити якість професійної підготовки фахівців, зокрема, технічних спеціальностей. Проведений аналіз засобів навчання, що використовуються під час вивчення загальнотехнічних дисциплін, дав можливість провести аналогію між фізичними і електронними моделями та обґрунтувати розробку програмного забезпечення для розвитку просторового мислення студентів технічних спеціальностей. Подано методику створення мобільних додатків для доповненої реальності, висвітлено основні етапи розробки додатку доповненої реальності, починаючи від встановлення ігрового рушія до його тестування та демонстрації роботи. Особливу увагу приділено написанню та обґрунтуванню кожного рядка сценаріїв (scripts). Презентовано власну розробку мобільного додатку для мобільних пристроїв «Програма доповненої реальності», яка реалізує доповнену реальність. Створений мобільний додаток зчитує, розпізнає маркер кресленика та відображає на екрані мобільного пристрою електронну модель виробу. З’ясовано, що розроблена авторським колективом програма доповненої реальності як мобільний педагогічний програмний засіб може бути використана для підтримки як самостійної роботи студентів, так і при організації аудиторних занять у закладах вищої освіти.
ЦИФРОВИЙ СТОРІТЕЛІНГ В ОСВІТІ ДОРОСЛИХ: БАР’ЄРИ ТА ШЛЯХИ ЇХ ПОДОЛАННЯ
Authors: Панченко Любов Феліксівна
Published: October 2020

У сучасному цифровому глобалізованому світі зростає важливість підготовки педагогів до практичного застосування нових засобів та технологій, зокрема технології цифрового сторітелінгу, або розповіді цифрових історій за допомогою сучасних комп’ютерних засобів. У статті обґрунтовуються переваги цифрового сторітелінгу, його зв'язок з освітніми стандартами; аналізуються фактори, які перешкоджають його використанню. За даними опитування науково-педагогічних працівників та методистів різного фаху під час курсів підвищення кваліфікації з’ясовано, що тільки чверть респондентів використовувала чи використовує цей метод, а близько 72% опитаних готові розглянути таку можливість. За емпіричними даними засобами факторного аналізу побудовано модель щодо можливих чинників, які перешкоджають використанню цифрового сторітелінгу в освіті. Перший фактор пов'язаний з відсутністю необхідних засобів, другий – з опором до змін, третій – з браком часу та відсутністю технічної та методичної підтримки з боку освітнього закладу. Визначаються можливі шляхи подолання цих бар’єрів. Розкрито структуру та зміст спецкурсу для науково-педагогічних працівників та методистів системи освіти «Цифровий сторітелінг в освіті дорослих», який пропонується в межах системи підвищення кваліфікації. Мета спецкурсу: забезпечити методичну підтримку освітян з питань цифрового сторітелінгу та його використання шляхом обговорень сильних та слабких сторін; прийомів, засобів та сервісів; надання досвіду створення та поширення цифрових історій. Розроблено методичне забезпечення спецкурсу: програма спецкурсу, лекції-презентації з основ цифрового сторітелінгу, практичні завдання для виконання та обговорення. Обґрунтовано зміст етапів залучення науково-педагогічних працівників до технологічно доповненої цифровим сторітелінгом освітньої практики (орієнтації, прийняття, оцінки, інновацій та інституціоналізації). Аналізуються шляхи використання фрагментів масових онлайн курсів з тематики цифрового сторітелінгу для здійснення змішаного навчання науково-педагогічних працівників.
ВІРТУАЛЬНИЙ НАУКОВО-НАВЧАЛЬНИЙ ЦЕНТР ДЛЯ ПІДГОТОВКИ ОПЕРАТИВНО-ДИСПЕТЧЕРСЬКОГО ПЕРСОНАЛУ В ЕНЕРГЕТИЦІ УКРАЇНИ
Authors: Куцан Юлій Григорович , Гурєєв Віктор Олександрович , Яцишин Андрій Васильович , Яцишин Анна Володимирівна
Published: October 2020

Нині навчання та тренажерна підготовка персоналу в енергетичній галузі України має значні недоліки, що не дозволяє виконувати повною мірою зобов’язання перед міжнародними організаціями. У статті обґрунтовано важливість використання сучасних веб орієнтованих технологій для підвищення кваліфікації оперативно-диспетчерського персоналу в енергетичній галузі України. Описано особливості створення навчально-методичної бази для системи підготовки та підвищення кваліфікації оперативно-диспетчерського персоналу в енергетиці з метою формування й підтримки ключових компетентностей оперативного персоналу. Розглядаються переваги застосування розподіленого середовища для організації навчання і тренажерної підготовки оперативного персоналу за допомогою засобів моделювання режимів роботи електроенергетичних систем (ЕЕС) у віртуальному центрі. У результаті проведеного дослідження обґрунтовано навчально-методичну базу, структуру та функції віртуального науково-навчального центру для підвищення кваліфікації персоналу в енергетичній галузі України, який виконує такі функції: контроль знань, тренажерна підготовка, формування ключових компетентностей. Подано основні компоненти дистанційних курсів (ДК) з використанням спеціалізованих програмно-моделюючих систем для тренажерної підготовки персоналу в енергетиці. Тематика пропонованих ДК складається з лекцій, практичних занять та семінарів, передбачає проведення консультацій з викладачами і самостійну позааудиторну роботу персоналу у вільний або в робочій час. Важливим практичним аспектом в авторських ДК є використання інформаційно-програмного забезпечення для стійкого формування в персоналу енергетичної галузі ключових компетентностей зі швидкого розпізнавання умов виникнення аварій та, за необхідності, швидкої ліквідації їх наслідків. Це дозволить оволодіти знаннями та практичними навичками для розв’язання задач аналізу, моделювання, прогнозування та візуалізації даних моніторингу режимів роботи великих ЕЕС. Отже, для підвищення кваліфікації персоналу в енергетичній галузі України було розроблено і впроваджено: віртуальний науково-навчальний центр (ВННЦ) та забезпечено його наукову підтримку; розроблено та впроваджено ДК для організації змішаного навчання персоналу; розроблено та впроваджено повнофункціональний режимний вебтренажер (ПОРТ). Використання персоналом у галузі енергетики ВННЦ дозволить створити систему підготовки персоналу найвищої якості.
STRUCTURAL AND METHODOLOGICAL ASPECTS OF RESEARCH TYPOLOGIZATION ON THE USE OF ICT IN SECONDARY SCHOOL
Authors: Гривко Антоніна Вікторівна
Published: October 2020

The article features a methodology for systematization of research on ICT use in secondary education. Making important decisions about improving school education, including through the introduction of certain information and communication technologies into the educational process, is based on the study of relevant experience and relevant research results. The large number of diversified scientific works that make up the theoretical, practical, and methodological basis of the ICT use in school education necessitates the generalization, ordering, and determination of their typological features. The author singles out the following groups of studies related to the ICT use in school: generalizing theoretical-analytical (documentary), empirical and complex. Each of the groups is characterized by a variable set of typological features in terms of scale and independence of their conduct. They allow distinguishing their main types (10 types of research are considered in the article, for example, empirical/international large-scale/contextual studies or complex/local/separate studies, etc.). The author determined the structural and methodological criteria for the analysis of different research types (thematic, targeted, sampling, organizational, methodological, analytical, resultant) and carried out a selective analysis of the studies on the proposed typological features, structural and methodological criteria, the results of which were systematized in the matrix of methodological analysis of different research types on the ICT use in school education. According to the results of the works review, topical thematic areas of the analyzed research were identified, typical methods of data collection and analysis were singled out and the format of results reporting was highlighted for each selected research group. The approach to systematizing research on the use of ICT in secondary education institutions, presented in the proposed article, can be applied during the review of scientific achievements, the analysis of pedagogical research in the field of ICT, or to design individual research. Filling in the proposed analysis matrix will allow it to be further used as a database of relevant research papers, facilitate the search and selection of those that meet the objectives of a specific scientific search.
ІНТЕРНЕТ ОРІЄНТОВАНА МОДЕЛЬ НАВЧАННЯ УЧНІВ СТАРШОЇ ШКОЛИ ІНТЕГРОВАНОГО КУРСУ «ПРИРОДНИЧІ НАУКИ»
Authors: Засєкіна Тетяна Миколаївна
Published: October 2020

У статті презентовані результати наукового пошуку моделі навчання інтегрованому курсу «Природничі науки» для 10-11 класів закладів загальної середньої освіти, її теоретичне обґрунтування та практична перевірка якості й результативності. Наказом МОН України №863 від 03.08.2018 року «Про проведення експерименту всеукраїнського рівня «Розроблення і впровадження навчально-методичного забезпечення інтегрованого курсу «Природничі науки» для 10-11 класів закладів загальної середньої освіти» на серпень 2018 – жовтень 2022 роки» розпочато апробацію вказаного курсу. На початок експерименту вчителі й учні у своєму розпорядженні мали чотири варіанти навчальних програм (на вибір), незначну й несистематизовану кількість методичних рекомендацій і навчальних матеріалів, які здебільшого представлені в електронному форматі. Виникла проблема, яка потребувала негайного вирішення – як організувати освітній процес за відсутності повноцінного навчально-методичного забезпечення курсу. Найбільш дієвим у цьому випадку є організація навчання з використанням елементів електронного навчання. На основі теоретичних й емпіричних досліджень нами розроблено й апробовано модель такого навчання, що забезпечує досягнення визначених компетентностей і результатів навчання здобувачів освіти. Провідними підходами, які застосовні в нашій моделі, є модульний, діяльнісний, компетентнісний, особистісно-орієнтований та інтегрований. Серед методів навчання – метод проєктів, навчання у співробітництві, дослідницький. Серед прийомів – робота з інформацією, створення інформаційних продуктів. Серед видів оцінювання – формувальне. Основними електронними ресурсами є: освітні Інтернет-ресурси (група офіційних сайтів установ, видавництв (блогів учасників експерименту), де висвітлюється нормативне й навчально-методичне забезпечення впровадження курсу «Природничі науки»; група тематичних інформаційно-наукових і освітніх ресурсів (бібліотеки, дистанційні курси тощо); група цифрових інструментів і сервісів (віртуальних дошок, тренажерів, онлайн тестування і т.п.).
Half a century of monitoring macrobenthic animals on tidal flats in the Dutch Wadden Sea
Authors: Beukema JJ , Dekker R
Published: October 2020

Macrobenthic animals living in a tidal-flat area in the westernmost part of the Wadden Sea were monitored for 50 yr (1970-2019) using consistent methods. About 100 papers were published on this project. We review a number of results and conclusions on observed changes and their possible underlying causal processes. The most significant changes in population sizes and growth rates of several species could be attributed to climate warming (by about 2°C), along with increasing trends in species richness and total late-winter zoobenthic biomass. In the initial years, eutrophication (doubling of nutrients and chlorophyll concentrations) resulted in a doubling of zoobenthic biomass. The subsequent de-eutrophication after the mid-1980s was reflected only in the biomass values observed in late summer. A long-term trend in food supply for birds was not observed. Disturbances from fisheries were intermittent and modest. In several bivalve species, magnitudes of production and biomass were determined primarily by recruitment variation, which was mainly caused by spring abundance of epibenthic predators (shore crabs and shrimps). Their abundance increased with temperatures in the preceding winter. In contrast to this top-down regulation, bottom-up processes apparently played only a minor role in the determination of bivalve biomass. Rarely occurring extremely high bivalve numbers resulted in reduced rates of growth and production. We conclude that the uniquely long monitoring of the tidal-flat macrozoobenthos yielded data series which not only indicated several long-term trends, but also contributed to our insight in processes underlying the observed trends. Most of the observed trends were related to climate change and eutrophication followed by de-eutrophication.
SYNTHETIC POTENTIAL OF 9,10-ANTHRAQUINONYLDIAZONIUM SALTS
Authors: Stasevich Maryna , Zvarych Viktor , Novikov Volodymyr , Vovk Mykhailo
Published: October 2020

For the first time, the literature sources concerning the chemical transformations of diazonium salts of 1(2)-amino-9,10-anthracenediones are generalized and systematized. The potential of 9,10-dioxoanthracenyldiazonium salts as key substrates in the preparation of various linear-functionalized, acyclic and heterocyclic derivatives has been determined. The main synthetic transformations of diazonium salts of amino-9,10-anthracenediones, which are  realized without preserving the azo function lead to the formation of reaction products of Sandmeyer, Meerwein, and Gomberg–Bachmann–Hay, are analyzed. The use of 9,10-dioxoanthracenyldiazonium salts or products of their transformations for obtaining heteryl-containing condensed and functionalized derivatives is presented.
In-vitro Antibacterial Activity of Carbopol-Essential Oils hydrogels
Authors: Yahya Esam , Abdulsamad Muhanad Abdullah
Published: October 2020

Background and Objectives: The main purpose of the drug therapy of any disease is to maintain the desired therapeutic concen-tration of the drug for the entire duration of the treatment. The aim of this study is to formulate mixed essential oils loaded hydrogel, and evaluate its antibacterial activity against some pathogens. Materials and Methods: Different hydrogels were formulated by using different concentration of essential oils. Antibacterial evaluation was done using disk diffusion method. Screening for antibacterial activity of essential oils were studied prior to hydrogel formulation to compare the changes in activity after incorporation in the hydrogel. Results: Clove oil exhibited the strongest activity towards all the tested pathogens, compared to other tested essential oils (clove > cinnamon > tea tree > rosemary). The formulation containing mixed essential oils showed the best results, with synergistic effect against all tested pathogens. Hydrogels were further subjected to evaluation of physical properties like color, clarity, pH, viscosity and animal skin irritation study. The zone of inhibition of the final formulation containing only 3% from the selected three essential oils was between 18‐23 mm for S. aureus, 17‐20mm for E. coli, and 14‐18mm for P. aeruginosa. The hydrogels were non-irritant, stable, and free of any microbes at room temperature. Conclusion: Activity of essential oils was much affected by incorporation in hydrogel. The loaded hydrogel showed better antimicrobial activity against all the microorganisms used in the study, despite the need for clinical studies to determine of the effectiveness and potential toxic effects in-vivo.
Developing a Hyperparameter Tuning Based Machine Learning Approach of Heart Disease Prediction
Authors: Hashi Emrana Kabir , Md. Shahid Uz Zaman
Published: October 2020

Machine learning techniques are widely used in healthcare sectors to predict fatal diseases. The objective of this research was to develop and compare the performance of the traditional system with the proposed system that predicts the heart disease implementing the Logistic regression, K-nearest neighbor, Support vector machine, Decision tree, and Random Forest classification models. The proposed system helped to tune the hyperparameters using the grid search approach to the five mentioned classification algorithms. The performance of the heart disease prediction system is the major research issue. With the hyperparameter tuning model, it can be used to enhance the performance of the prediction models. The achievement of the traditional and proposed system was evaluated and compared in terms of accuracy, precision, recall, and F1 score. As the traditional system achieved accuracies between 81.97% and 90.16%., the proposed hyperparameter tuning model achieved accuracies in the range increased between 85.25% and 91.80%. These evaluations demonstrated that the proposed prediction approach is capable of achieving more accurate results compared with the traditional approach in predicting heart disease with the acquisition of feasible performance.
Jute Stick Powder: A new approach to efficient biosorbent for the simultaneous removal of Pb, Cr and Cd from waste water
Authors: Uddin Mohammad Nasir
Published: October 2020

This research was aimed to evaluate the potential of biosorption technique in more realistic conditions that appeal to the industry by exploiting locally available biosorbents such as jute stick powder (JSP), an agricultural product, for the removal of toxic Pb(II), Cr(III) and Cd(II) ions from wastewater. Fourier transform infrared spectroscopy (FTIR) and Scanning electron micrographs (SEM) analysis proved that the surface of biosorbent was porous, with heterogeneous structures that contained high internal spaces. The removal efficiencies of the mixture of the target metals by JSP were optimized with respect to pH, initial metal concentration, shaking time and biomass dose. Biosorption performance of JSP in multiple metal systems was above 90 percent adsorption for tested metal ions. Biomass regeneration efficiencies up to 98% were achieved using acid as eluent. Sorption performance of the JSP as biosorbent was examined by classical adsorption equilibrium isotherms, kinetics in batch systems, and dynamic continuous flow studies. Batch sorption studies revealed that pseudo-first, pseudo-second-order, and Langmuir isotherm models were suitable to describe the metals sorption kinetics and equilibrium, respectively.
TANGGAPAN GURU PAUD TENTANG PEMBERIAN REWARD DAN PENGARUHNYA TERHADAP MOTIVASI BELAJAR DAN PERKEMBANGAN SOSIAL EMOSIONAL ANAK USIA DINI
Authors: Astari Tiara , Nur Aisyah Siti , Andika Sari Diah
Published: October 2020

The purpose of this study was to determine the responses of PAUD teachers in East Ciputat sub-district regarding the effect of reward on learning motivation and socio-emotional development of early childhood. The method used is descriptive quantitative with survey techniques, using a questionnaire (questionnaire) using the google form application. Questionnaires (questionnaires) are given to respondents online via WhatsApp, then the collected data will be analyzed. The study population was kindergarten teachers in East Ciputat District, and the number of respondents was 100 people with the sampling technique using simple random sampling. From the data obtained, as many as 80% of respondents answered that they often gave rewards in the form of good words, namely: good, true, great, cool and smart to children. In addition, as many as 65% of respondents answered that very often they gave an assessment with a thumbs up, clapping and smiling. It is known that the results of the respondent's answer who gave an assessment in the form of a sticker or stamp were 70%. Meanwhile, 72% of respondents answered very often that motivation creates a desire to learn in school children. So motivation which serves as a driving force significantly influences learning attitudes in children. Furthermore, 67% of respondents answered that very often children do learning activities with all their soul and body (willing / not forced, happy, sincere). So based on the theory and the results of the respondents' answers, it can be concluded that motivation is the driving force of the desire to learn in children.
Quorum Sensing System Affects the Plant Growth Promotion Traits of Serratia fonticola GS2
Authors: Jung Byung Kwon , Ibal Jerald Conrad , Pham Huy Quang , Kim Min-Chul , Park Gun-Seok , Hong Sung-Jun , Jo Hyung Woo , Park Chang Eon , Choi Seung-Dae , Jung Yeongyun , Tagele Setu Bazie , Shin Jae-Ho
Published: October 2020

Quorum sensing (QS) enables bacteria to organize gene expression programs, thereby coordinating collective behaviors. It involves the production, release, and population-wide detection of extracellular signaling molecules. The cellular processes regulated by QS in bacteria are diverse and may be used in mutualistic coordination or in response to changing environmental conditions. Here, we focused on the influence of the QS-dependent genes of our model bacterial strain Serratia fonticola GS2 on potential plant growth promoting (PGP) activities including indole-3-acetic acid (IAA) production, 1-aminocyclopropane-1-carboxylate (ACC) deaminase activity, and biofilm formation. Based on genomic and phenotypic experimental data we identified and investigated the function of QS genes in the genome of the model strain. Our gene deletion study confirmed the biological functionality of the QS auto-inducer (gloI) and receptor (gloR) on potential PGP activities of GS2. A transcriptomic approach was also undertaken to understand the role of QS genes in regulation of genes primarily involved in PGP activities (IAA, ACC deaminase activity, and biofilm formation). Both transcriptomic and phenotypic data revealed that the QS-deletion mutants had considerably less PGP activities, as compared to the wild type. In addition, in vivo plant experiments showed that plants treated with GS2 had significantly higher growth rates than plants treated with the QS-deletion mutants. Overall, our results showed how QS-dependent genes regulate the potential PGP activities of GS2. This information may be helpful in understanding the relationship between QS-dependent genes and the PGP activity of bacteria, which aid in the production of practical bio-fertilizers for plant growth promotion.
Overgrowth Syndromes—Evaluation, Diagnosis, and Management
Authors: Manor Joshua , Lalani Seema R.
Published: October 2020

Abnormally excessive growth results from perturbation of a complex interplay of genetic, epigenetic, and hormonal factors that orchestrate human growth. Overgrowth syndromes generally present with inherent health concerns and, in some instances, an increased risk of tumor predisposition that necessitate prompt diagnosis and appropriate referral. In this review, we introduce some of the more common overgrowth syndromes, along with their molecular mechanisms, diagnostics, and medical complications for improved recognition and management of patients affected with these disorders.
An Investigation of What Factors Determine the Way in Which Customer Satisfaction Is Increased through Omni-Channel Marketing in Retail
Authors: Merritt Kamarin , Zhao Shichao
Published: October 2020

There have been significant changes evident across the retail sector over the last 20 years, which have been primarily influenced by technological advancements. These changes have forced many retailers to rethink their business models and utilise a combination of both brick and mortar stores and online domains to present an integrated shopping experience. In order to gain an understanding of how customer satisfaction is increased through omni-channel retailing, we collected data through survey research, specifically through semi-structured interviews and questionnaires. In order to generate concise and accurate findings, the data were analysed using thematic analysis. From this analysis, three themes were generated. The first theme explores the reasoning behind preferred shopping methods and what influences these customers’ purchase methods. The second theme explores customers’ personal preference and investigates the potential of using virtual reality as a method for increasing customer satisfaction. Finally, the third theme looks into utilising interactive technology to create a diversified user experience. This theme explores the potential of utilising a communication platform for customers and also designing a tangible interface for disabled customers. This study has opened up an opportunity for future research and has outlined potential design insights in how to improve customer experience and customer purchase intentions.
Unrestricted Feed Intake Induces β-Cell Death and Impairs Insulin Secretion in Broiler Breeder Hens
Authors: Huang Yu-Feng , Chang Ling-Chu , Chen Chung-Yu , Chen Yu-Hui , Walzem Rosemary L. , Chen Shuen-Ei
Published: October 2020

Past studies regarding to insulin secretion and glucose disposal in chickens were focused on rapidly growing juvenile broilers and may not reflect glucose/insulin physiology in adulthood. The study aimed to assess insulin secretion and glucose disposal in respect to restricted (R) vs. ad libitum (Ad) feed intake for obesity development in broiler breeder hens. Hens at age of 26 weeks were continued on R rations, or allowed Ad-feed intake up to 45 weeks. Results from prandial changes and glucose tolerance test suggested that Ad-feed intake to 45 weeks impaired insulin secretion and glucose clearance, and, thus, caused hyperglycemia in accompany with transient hyperinsulinemia at age of 33 weeks (p < 0.05). The alterations were shown operating at both transcript and protein level of insulin gene expression per se and at ATP supply for insulin release as evidenced by consistent changes of enzyme expression and activity in pyruvate anaplerosis in the β-islets (p < 0.05). Ad-feed intake also increased β-islet triacylglycerol and ceramide accumulation and provoked interleukin-1β (IL-1β) production (p < 0.05), which were further manifested by a detrimental increase of caspase 3/7 activity and cell apoptosis (p < 0.05). Results support the conclusion that release to Ad-feed intake in broiler breeder hens transiently induced hyperinsulinemia along rapid bodyweight gain and adiposity, but later provoked lipotoxicity and inflammation leading to β-cell apoptosis and ultimately impaired insulin secretion and glucose disposal.
Exosomes as a Potential Tool for Supporting Canine Oocyte Development
Authors: Lee Seok Hee , Saadeldin Islam M.
Published: October 2020

The canine oviduct is a unique reproductive organ where the ovulated immature oocytes complete their maturation, while the other mammals ovulate matured gametes. Due to their peculiar reproductive characteristics, the in vitro maturation of dog oocytes is still not wellestablished compared with other mammals. Investigations of the microenvironment conditions in the oviductal canal are required to establish a reliable in vitro maturation system in the dog. Previous studies have suggested that the oviduct and its derivatives play a key role in improving fertilization as well as embryo development. In particular, the biological function of oviduct-derived exosomes on sperm and early embryo development has been investigated in porcine, bovine, and murine species. However, the information about their functions on canine cumulus-oocyte complexes is still elusive. Recent canine reproductive studies demonstrated how oviduct-derived extracellular vesicles such as microvesicles and exosomes interact with oocyte-cumulus complexes and how they can play roles in regulating canine cumulus/oocyte communications. In this review, we summarize the physiological characteristics of canine oviduct-derived exosomes and their potential effects on cumulus cells development as well as oocyte in vitro maturation via molecular signaling pathways.
Effects of the Dietary Inclusion of Buriti Oil on Lamb Performance, Carcass Traits, Digestibility, Nitrogen Balance, Ingestive Behavior and Blood Metabolites
Authors: Diogénes Luciana , Bezerra Leilson , Pereira Filho José , Silva Junior Jarbas , Oliveira Juliana , Moura José , Barbosa Analivia , Souza Mateus , Sousa Sheila , Pereira Elzânia , Oliveira Ronaldo
Published: October 2020

Buriti (Mauritia flexuosa L.) oil (BO) is a byproduct that can be incorporated into the diet of lambs, thus increasing the energy density. The study aimed to evaluate the optimum BO inclusion level in lamb diets. Sixty-five Santa Ines lambs were distributed in two completely randomized experiments with five treatments each (BO inclusion at 0 (control), 12, 24, 36 and 48 g/kg dry matter (DM) total). The BO supplementation to partially replace ground corn linearly decreased the nutrient intake and digestibility of DM, ether extract and neutral detergent fiber (NDF), N° chews/bolus, DM and NDF rumination or eating efficiencies, the N intake and N balance, carcass weights and yields, and dressing content of lamb carcasses (p < 0.05). The addition of BO responded quadratically to DM eating efficiency and N-fecal and N-urinary excretion (p < 0.05). The linear response plateau (LRP) analysis demonstrated that the levels of 0 and 12 g/kg of BO were similar, and improved intake and digestibility and consequently performance (p < 0.001). There was a linear increase in feed efficiency and shrinkage after chilling with the BO inclusion replacing ground corn. The inclusion of 12 g/kg BO in the total DM of diet is recommended, because it improves feeding intake, digestibility and performance of lambs.
Swim Bladder Disorders in Koi Carp (Cyprinus carpio)
Authors: Sirri Rubina , Mandrioli Luciana , Zamparo Samuele , Errani Francesca , Volpe Enrico , Tura Giorgia , Barbé Tim , Ciulli Sara
Published: October 2020

Swim bladder disorders and consequent buoyancy problems are encountered in ornamental fish, including koi carp. Nevertheless, beyond clinical and pharmacological management, they are largely underdiagnosed. In this study, nine koi carp showing abdominal swelling and abnormal swimming behavior were investigated. Clinical approach, varying from case to case, included ultrasonographic and X-ray investigations, bacteriological analysis of the collected fluid, antimicrobial susceptibility pattern, and possibly histological analysis. Diagnostic imaging, corroborating gross examination, documented swim bladder deformation/dislocation and serous fluid within the swim bladder chambers of most animals. Bacteria belonging to the Aeromonas hydrophila/caviae group and Shewanella xiamenensis were identified. S. xiamenensis strains showed a sensibility to all tested molecules except for one strain, which was resistant to tetracycline and cyprofloxacin. Antibiotic treatment succeeded in the full recovery of three cases in which S. xiamemensis infection was detected. Chronic aerocystitis was histologically documented where tissue was available. The swim bladder histopathological findings highlighted a chronic process that had compromised the quality of life of the animals. A multidisciplinary clinical–pathological and microbiological approach is highly suggested to recognize swim bladder conditions as early as possible, aiming to drive medical intervention and raising the chances of fish survival.