bluuebunny/crossref_metadata_2025 huggingface dataset:
Hybrid phase retrieval algorithm based on modified very fast simulated annealing
Authors: Xu Yueshu , Ye Qian , Meng Guoxiang
Published: June 2018

The Misell algorithm is one of the most widely used phase retrieval holography methods for large reflector antennas to measure surface deformation. However, it usually locks in a local minimum because it heads downhill from an initial estimation without any consideration whether it heads for a global minimum or not. The core problem of the Misell algorithm is to find an initial estimation near the global minimum to avoid local stagnation. To cope with the problem, we construct a hybrid Misell algorithm, named modified very fast simulated annealing (MVFSA)-Misell algorithm, to search for the global minimum with a high efficiency. The algorithm is based on the combination of the MVFSA algorithm and Misell algorithm. Firstly, the MVFSA is utilized to obtain a rough position near the global minimum in limited steps. Then, the Misell algorithm starts from the rough position to converge to the global minimum with high speed and accuracy. The convergence characteristic of the proposed algorithm was discussed in detail through digital simulation. Simulation results show that the algorithm can reach global minimum in a very short time. Unlike the traditional Misell algorithm, the hybrid algorithm is not influenced by initial phase estimation.
Resistance to Multiple PRE Herbicides in a Field-evolved Rigid Ryegrass (Lolium rigidum) Population
Authors: Brunton David J. , Boutsalis Peter , Gill Gurjeet , Preston Christopher
Published: June 2018

A population of rigid ryegrass (Lolium rigidumGaudin) from a field on the Eyre Peninsula, South Australia, was suspected of resistance to thiocarbamate herbicides. Dose–response studies were conducted on this population (EP162) and two susceptible populations (SLR4 and VLR1). The resistant population exhibited cross-resistance to triallate, prosulfocarb, EPTC, and thiobencarb with higher LD50to triallate (14.9-fold), prosulfocarb (9.4-fold), EPTC (9.7-fold), and thiobencarb (13.6-fold) compared with the susceptible populations SLR4 and VLR1. The resistant population also displayed resistance to trifluralin, pyroxasulfone, and propyzamide. The LD50of the resistant population was higher for trifluralin (13.8-fold), pyroxasulfone (8.1-fold), and propyzamide (2.7-fold) compared with the susceptible populations. This study documents the first case of field-evolved resistance to thiocarbamate herbicides inL. rigidum.
Weather, Risk, and Voting: An Experimental Analysis of the Effect of Weather on Vote Choice
Authors: Bassi Anna
Published: June 2018

A number of theoretical and empirical studies analyze the effect of inclement weather on voter turnout and in turn on parties’ vote share. However, empirical findings suggest that the effect of weather on parties’ vote share is greater than can be explained by its influence on voter turnout alone. This article provides experimental evidence of the effect of weather on vote choice between more- versus less-risky candidates. Findings show that bad weather significantly and sizeably depresses risk tolerance making voters less likely to vote for risky candidates. This article also provides evidence of a possible mechanism: unpleasant weather conditions depress agents’ mood, making agents less inclined to vote for candidates who are perceived as more risky.
Before I Die
Authors: Chu Qiao , Grühn Daniel , Holland Ashley M.
Published: June 2018

Abstract. We investigated the effects of time horizon and age on the socioemotional motives underlying individual’s bucket-list goals. Participants were randomly assigned to one of three time-horizon conditions to make a bucket list: (1) an open-ended time horizon (Study 1 & 2), (2) a 6-month horizon (i.e., “Imagine you have 6 months to live”; Study 1 & 2), and (3) a 1-week horizon (Study 2). Goal motives were coded based on socioemotional selectivity theory and psychosocial development theory. Results indicated that time horizon and age produced unique effects on bucket-list goal motives. Extending past findings on people’s motives considering the end of life, the findings suggest that different time horizons and life stages trigger different motives.
Future Time Perspective Moderates Consumer Responses to Nostalgic Advertising
Authors: Ju Ilyoung , Bluck Susan , Liao Hsiao-Wen
Published: June 2018

Abstract. Humans remember their past and consider their future. Nostalgic advertising, focused on the personal past, increases positive consumer response to products. This research examines how future time perspective (FTP) moderates that effect. Based on socioemotional selectivity theory, the products studied represent goals individuals have when time feels limited (i.e., camera: familiar, socially focused, emotionally meaningful) or open-ended (i.e., VR-One: novel, information-focused, entertaining). As expected, ad-evoked nostalgia heightens positive consumer response to the camera, increasingly so when FTP feels limited (Study 1; N = 288). For the VR-One, ad-evoked nostalgia again increases positive response but less so when time feels limited (Study 2; N = 283). Thinking about how the past and the future interact to influence consumer preferences in adulthood is discussed.
Future Time Perspective
Authors: Liao Hsiao-Wen , Carstensen Laura L.
Published: June 2018

Abstract. The articles in the present volume enhance the understanding of the role of perceived time in human development. Together, they point to the multifaceted nature of perceived future time and the associations different aspects of time have with goals, preferences, and well-being. Specifically, the articles showcase antecedents and consequences of perceived time left in life, consider ways to optimize measurement of future time horizons, and advance novel questions about the neural correlates of domain-specific aspects of subjective time. Findings are considered within the framework of socioemotional selectivity theory. Future directions for research on time horizons are discussed.
Potential Interventions for Preventing Pesticide Self-Poisoning by Restricting Access Through Vendors in Sri Lanka
Authors: Weerasinghe Manjula , Konradsen Flemming , Eddleston Michael , Pearson Melissa , Jayamanne Shaluka , Gunnell David , Hawton Keith , Agampodi Suneth
Published: June 2018

Abstract. Background: In South Asia, up to one in five individuals who use pesticides for self-harm purchase them immediately prior to the event. Aims: From reviewing the literature we proposed four interventions: (a) farmer identification cards (ID); (b) prescriptions; (c) cooling-off periods; and (d) training pesticide vendors. We aimed to identify the most promising intervention. Method: The study was conducted in Sri Lanka. We mapped stakeholders' interest and power in relation to each intervention, and followed this by a ranking exercise. Seven focus group discussions (FGDs) were conducted to assess facilitators and barriers to implementation. Results: Vendor training was the most supported intervention, being ranked first by the stakeholders. The participants in the FGDs strongly supported training of vendors as it was seen to be easy to implement and was considered more convenient. Farmer IDs, prescriptions, and cooling-off periods were thought to have more barriers than facilitators and they were strongly opposed by end users (farmers and vendors), who would potentially block their implementation. Limitations: Cost considerations for implementing the proposed intervention were not considered. Conclusion: Training vendors might be the most appropriate intervention to restrict sales of pesticides to people at risk of suicidal behavior. This requires field testing.
Psychosocial Factors Associated With Suicide Attempts, Ideation, and Future Risk in Lesbian, Gay, and Bisexual Youth
Authors: Rimes Katharine A. , Shivakumar Sandhya , Ussher Greg , Baker Dan , Rahman Qazi , West Elizabeth
Published: June 2018

Abstract. Background: Lesbian, gay, and bisexual (LGB) youth have elevated suicidality rates. Aims: To investigate LGB-related and other factors associated with suicide attempts, suicidal ideation, and future suicide risk in a large UK sample. Method: Logistic regression was used to investigate factors associated with suicidality in 3,275 LGB young adults from the Youth Chances project. Results: Suicide attempts (lifetime) were reported by 13.6% of participants; 45.2 % had suicidal ideation in the past year and 9.5% said future suicide attempts were likely. LGB stigma and discrimination experiences were significantly associated with all three aspects of suicidality. These included school stigma factors (e.g., teachers not speaking out against prejudice, lessons being negative about sexual minorities), negative reactions to coming out from family and friends, and LGB-related harassment or crime experiences. Bisexuality, not feeling accepted where one lives, younger sexual minority identification, and younger coming out were also associated with suicidality. Significant non-LGB factors included female gender, lower social support, anxiety/depression help-seeking, experiences of abuse/violence, and sexual abuse. Limitations: This study is cross-sectional and further research is needed to test out whether any of these factors have a causal relationship with suicidality. Conclusion: A wide range of LGB stigma and discrimination experiences are associated with increased suicidality in LGB youth. Health, social care, and education professionals supporting young people should address LGB-specific risk factors.
Assessing a Bayesian Embedding Approach to Circular Regression	Models
Authors: Cremers Jolien , Mainhard Tim , Klugkist Irene
Published: June 2018

Abstract. Circular data is different from linear data and its analysis also requires methods different from conventional methods. In this study a Bayesian embedding approach to estimating circular regression models is investigated, by means of simulation studies, in terms of performance, efficiency, and flexibility. A new Markov chain Monte Carlo (MCMC) sampling method is proposed and contrasted to an existing method. An empirical example of a regression model predicting teachers’ scores on the interpersonal circumplex will be used throughout. Performance and efficiency are better for the newly proposed sampler and reasonable to good in most situations. Furthermore, the method in general is deemed very flexible. Additional research should be done that provides an overview of what circular data looks like in practice, investigates the interpretation of the circular effects and examines how we might conduct a way of hypothesis testing or model checking for the embedding approach.
Coupled Snow Cover and Avalanche Dynamics Simulations to Evaluate Wet Snow Avalanche Activity
Authors: Wever Nander , Vera Valero Cesar , Techel Frank
Published: June 2018

We present physics‐based snowpack simulations for four snow seasons with detailed wet snow avalanche activity records. The distributed, spatially explicit simulations using the Alpine3D and SNOWPACK model show that the simulated snowpack in the release areas of documented wet snow avalanches often exhibits its first wetting of the season on the release day. This first wetting is accompanied in the simulations by liquid water accumulating on capillary barriers, often formed by depth hoar layers. The strongest water accumulations and largest increases in percolation depth are found on the day of avalanche release. For individual avalanche paths, however, this only holds in 25%–30% of the cases. Assuming that the depth of the strongest water accumulation corresponds to the avalanche fracture depth, the avalanche dynamics model RAMMS‐Extended was run using simulated snowpack properties as initial conditions in the release area and boundary conditions along the avalanche path. On average, the simulated affected area by the avalanche and runout distance for the release day are statistically significant in closer agreement with the observations than two days before the release. This does not hold for the simulations of 1 day before and 1 and 2 days after the release. This suggests that fracture depths and the temporal evolution of percolation depths are adequately simulated within a ±1‐day period. The results show a large potential for distributed snow cover and avalanche dynamics simulations to assess wet snow avalanche hazards, although predictions for individual avalanche paths remain challenging.
Detecting Lightning Infrasound Using a High‐Altitude Balloon
Authors: Lamb Oliver D. , Lees Jonathan M. , Bowman Daniel C.
Published: June 2018

Acoustic waves with a wide range of frequencies are generated by lightning strokes during thunderstorms, including infrasonic waves (0.1 to 20 Hz). The source mechanism for these low‐frequency acoustic waves is still debated, and studies have so far been limited to ground‐based instruments. Here we report the first confirmed detection of lightning‐generated infrasound with acoustic instruments suspended at stratospheric altitudes using a free‐flying balloon. We observe high‐amplitude signals generated by lightning strokes located within 100 km of the balloon as it flew over the Tasman Sea on 17 May 2016. The signals share many characteristics with waveforms recorded previously by ground‐based instruments near thunderstorms. The ability to measure lightning activity with high‐altitude infrasound instruments has demonstrated the potential for using these platforms to image the full acoustic wavefield in the atmosphere. Furthermore, it validates the use of these platforms for recording and characterizing infrasonic sources located beyond the detection range of ground‐based instruments.
A Case Study of Near‐Earth Magnetotail Conditions at Substorm and Pseudosubstorm Onsets
Authors: Miyashita Y. , Angelopoulos V. , Fukui K. , Machida S.
Published: June 2018

While a substorm involves auroral poleward expansion after initial brightening, a pseudosubstorm (pseudobreakup) subsides without progressing to poleward expansion. To understand what makes this difference, we studied near‐Earth magnetotail conditions at a pseudosubstorm onset and the subsequent substorm onset, using multipoint Time History of Events and Macroscale Interactions during Substorms spacecraft data. In the present event, near‐Earth magnetic reconnection possibly occurred before initial brightening for both pseudosubstorm and substorm. In the near‐Earth magnetotail at X ∼− 10 RE, the ion β, ion pressure, and ion and total (ion plus magnetic) pressure gradient projection along two closely located spacecraft were smaller and magnetic field lines were less stretched around the pseudosubstorm initial brightening than around the substorm initial brightening. Dipolarization did not occur for the pseudosubstorm, whereas it began just before poleward expansion for the substorm. These observations suggest that conditions of the near‐Earth magnetotail possibly affect whether the initial action develops into a full‐fledged substorm.
Linking patterns of net community production and marine microbial community structure in the western North Atlantic
Authors: Wang Seaver , Lin Yajuan , Gifford Scott , Eveleth Rachel , Cassar Nicolas
Published: June 2018

Marine net community production (NCP) tracks uptake of carbon by plankton communities and its potential transport to depth. Relationships between marine microbial community composition and NCP currently remain unclear despite their importance for assessing how different taxa impact carbon export. We conducted 16 and 18S rRNA gene (rDNA) sequencing on samples collected across the Western North Atlantic in parallel with high-resolution O2/Ar-derived NCP measurements. Using an internal standard technique to estimate in-situ prokaryotic and eukaryotic rDNA abundances per liter, we employed statistical approaches to relate patterns of microbial diversity to NCP. Taxonomic abundances calculated using internal standards provided valuable context to traditional relative abundance metrics. A bloom in the Mid-Atlantic Bight featured high eukaryote abundances with low eukaryotic diversity and was associated with the harmful algal bloom-forming Aureococcus anophagefferens, phagotrophic algae, heterotrophic flagellates, and particle-associated bacteria. These results show that coastal Aureococcus blooms host a distinct community associated with regionally significant peaks in NCP. Meanwhile, weak relationships between taxonomy and NCP in less-productive waters suggest that productivity across much of this region is not linked to specific microplankton taxa.
Global pairwise RNA interaction landscapes reveal core features of protein recognition
Authors: Zhou Qin , Kunder Nikesh , De la Paz José Alberto , Lasley Alexandra E. , Bhat Vandita D. , Morcos Faruck , Campbell Zachary T.
Published: June 2018

RNA–protein interactions permeate biology. Transcription, translation, and splicing all hinge on the recognition of structured RNA elements by RNA-binding proteins. Models of RNA–protein interactions are generally limited to short linear motifs and structures because of the vast sequence sampling required to access longer elements. Here, we develop an integrated approach that calculates global pairwise interaction scores from in vitro selection and high-throughput sequencing. We examine four RNA-binding proteins of phage, viral, and human origin. Our approach reveals regulatory motifs, discriminates between regulated and non-regulated RNAs within their native genomic context, and correctly predicts the consequence of mutational events on binding activity. We design binding elements that improve binding activity in cells and infer mutational pathways that reveal permissive versus disruptive evolutionary trajectories between regulated motifs. These coupling landscapes are broadly applicable for the discovery and characterization of protein–RNA recognition at single nucleotide resolution.
Astrometrically registered maps of H2O and SiO masers toward VX Sagittarii
Authors: Yoon Dong-Hwan , Cho Se-Hyung , Yun Youngjoo , Choi Yoon Kyung , Dodson Richard , Rioja María , Kim Jaeheon , Imai Hiroshi , Kim Dongjin , Yang Haneul , Byun Do-Young
Published: June 2018

The supergiant VX Sagittarii is a strong emitter of both H2O and SiO masers. However, previous VLBI observations have been performed separately, which makes it difficult to spatially trace the outward transfer of the material consecutively. Here we present the astrometrically registered, simultaneous maps of 22.2 GHz H2O and 43.1/42.8/86.2/129.3 GHz SiO masers toward VX Sagittarii. The H2O masers detected above the dust-forming layers have an asymmetric distribution. The multi-transition SiO masers are nearly circular ring, suggesting spherically symmetric wind within a few stellar radii. These results provide the clear evidence that the asymmetry in the outflow is enhanced after the smaller molecular gas clump transform into the inhomogeneous dust layers. The 129.3 GHz maser arises from the outermost region compared to that of 43.1/42.8/86.2 GHz SiO masers. The ring size of the 129.3 GHz maser is maximized around the optical maximum, suggesting that radiative pumping is dominant.
Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex
Authors: Bagur Sophie , Averseng Martin , Elgueda Diego , David Stephen , Fritz Jonathan , Yin Pingbo , Shamma Shihab , Boubenec Yves , Ostojic Srdjan
Published: June 2018

Primary sensory cortices are classically considered to extract and represent stimulus features, while association and higher-order areas are thought to carry information about stimulus meaning. Here we show that this information can in fact be found in the neuronal population code of the primary auditory cortex (A1). A1 activity was recorded in awake ferrets while they either passively listened or actively discriminated stimuli in a range of Go/No-Go paradigms, with different sounds and reinforcements. Population-level dimensionality reduction techniques reveal that task engagement induces a shift in stimulus encoding from a sensory to a behaviorally driven representation that specifically enhances the target stimulus in all paradigms. This shift partly relies on task-engagement-induced changes in spontaneous activity. Altogether, we show that A1 population activity bears strong similarities to frontal cortex responses. These findings indicate that primary sensory cortices implement a crucial change in the structure of population activity to extract task-relevant information during behavior.
Dynamic strain determination using fibre-optic cables allows imaging of seismological and structural features
Authors: Jousset Philippe , Reinsch Thomas , Ryberg Trond , Blanck Hanna , Clarke Andy , Aghayev Rufat , Hersir Gylfi P. , Henninges Jan , Weber Michael , Krawczyk Charlotte M.
Published: June 2018

Natural hazard prediction and efficient crust exploration require dense seismic observations both in time and space. Seismological techniques provide ground-motion data, whose accuracy depends on sensor characteristics and spatial distribution. Here we demonstrate that dynamic strain determination is possible with conventional fibre-optic cables deployed for telecommunication. Extending recently distributed acoustic sensing (DAS) studies, we present high resolution spatially un-aliased broadband strain data. We recorded seismic signals from natural and man-made sources with 4-m spacing along a 15-km-long fibre-optic cable layout on Reykjanes Peninsula, SW-Iceland. We identify with unprecedented resolution structural features such as normal faults and volcanic dykes in the Reykjanes Oblique Rift, allowing us to infer new dynamic fault processes. Conventional seismometer recordings, acquired simultaneously, validate the spectral amplitude DAS response between 0.1 and 100 Hz bandwidth. We suggest that the networks of fibre-optic telecommunication lines worldwide could be used as seismometers opening a new window for Earth hazard assessment and exploration.
Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
Authors: Baron Chloé S. , Kester Lennart , Klaus Anna , Boisset Jean-Charles , Thambyrajah Roshana , Yvernogeau Laurent , Kouskoff Valérie , Lacaud Georges , van Oudenaarden Alexander , Robin Catherine
Published: June 2018

Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The molecular events controlling endothelial specification, endothelial-to-haematopoietic transition (EHT) and IAHC formation, as it occurs in vivo inside the aorta, are still poorly understood. To gain insight in these processes, we performed single-cell RNA-sequencing of non-HE cells, HE cells, cells undergoing EHT, IAHC cells, and whole IAHCs isolated from mouse embryo aortas. Our analysis identified the genes and transcription factor networks activated during the endothelial-to-haematopoietic switch and IAHC cell maturation toward an HSC fate. Our study provides an unprecedented complete resource to study in depth HSC generation in vivo. It will pave the way for improving HSC production in vitro to address the growing need for tailor-made HSCs to treat patients with blood-related disorders.
Layered liquid crystal elastomer actuators
Authors: Guin Tyler , Settle Michael J. , Kowalski Benjamin A. , Auguste Anesia D. , Beblo Richard V. , Reich Gregory W. , White Timothy J.
Published: June 2018

Liquid crystalline elastomers (LCEs) are soft, anisotropic materials that exhibit large shape transformations when subjected to various stimuli. Here we demonstrate a facile approach to enhance the out-of-plane work capacity of these materials by an order of magnitude, to nearly 20 J/kg. The enhancement in force output is enabled by the development of a room temperature polymerizable composition used both to prepare individual films, organized via directed self-assembly to retain arrays of topological defect profiles, as well as act as an adhesive to combine the LCE layers. The material actuator is shown to displace a load >2500× heavier than its own weight nearly 0.5 mm.
Coherent two-dimensional electronic mass spectrometry
Authors: Roeding Sebastian , Brixner Tobias
Published: June 2018

Coherent two-dimensional (2D) optical spectroscopy has revolutionized our ability to probe many types of couplings and ultrafast dynamics in complex quantum systems. The dynamics and function of any quantum system strongly depend on couplings to the environment. Thus, studying coherent interactions for different environments remains a topic of tremendous interest. Here we introduce coherent 2D electronic mass spectrometry that allows 2D measurements on effusive molecular beams and thus on quantum systems with minimum system–bath interaction and employ this to identify the major ionization pathway of 3d Rydberg states in NO2. Furthermore, we present 2D spectra of multiphoton ionization, disclosing distinct differences in the nonlinear response functions leading to the ionization products. We also realize the equivalent of spectrally resolved transient-absorption measurements without the necessity for acquiring weak absorption changes. Using time-of-flight detection introduces cations as an observable, enabling the 2D spectroscopic study on isolated systems of photophysical and photochemical reactions.
Direct evidence for hula twist and single-bond rotation photoproducts
Authors: Gerwien Aaron , Schildhauer Monika , Thumser Stefan , Mayer Peter , Dube Henry
Published: June 2018

Photoisomerization reactions are quintessential processes driving molecular machines and motors, govern smart materials, catalytic processes, and photopharmacology, and lie at the heart of vision, phototaxis, or vitamin production. Despite this plethora of applications fundamental photoisomerization mechanisms are not well understood at present. The famous hula-twist motion—a coupled single and double-bond rotation—was proposed to explain proficient photoswitching in restricted environments but fast thermal follow-up reactions hamper identification of primary photo products. Herein we describe an asymmetric chromophore possessing four geometrically distinct diastereomeric states that do not interconvert thermally and can be crystallized separately. Employing this molecular setup direct and unequivocal evidence for the hula-twist photoreaction and for photoinduced single-bond rotation is obtained. The influences of the surrounding medium and temperature are quantified and used to favor unusual photoreactions. Based on our findings molecular engineers will be able to implement photo control of complex molecular motions more consciously.
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
Authors: Choy Mun-Kit , Javierre Biola M. , Williams Simon G. , Baross Stephanie L. , Liu Yingjuan , Wingett Steven W. , Akbarov Artur , Wallace Chris , Freire-Pritchett Paula , Rugg-Gunn Peter J. , Spivakov Mikhail , Fraser Peter , Keavney Bernard D.
Published: June 2018

Long-range chromosomal interactions bring distal regulatory elements and promoters together to regulate gene expression in biological processes. By performing promoter capture Hi-C (PCHi-C) on human embryonic stem cell-derived cardiomyocytes (hESC-CMs), we show that such promoter interactions are a key mechanism by which enhancers contact their target genes after hESC-CM differentiation from hESCs. We also show that the promoter interactome of hESC-CMs is associated with expression quantitative trait loci (eQTLs) in cardiac left ventricular tissue; captures the dynamic process of genome reorganisation after hESC-CM differentiation; overlaps genome-wide association study (GWAS) regions associated with heart rate; and identifies new candidate genes in such regions. These findings indicate that regulatory elements in hESC-CMs identified by our approach control gene expression involved in ventricular conduction and rhythm of the heart. The study of promoter interactions in other hESC-derived cell types may be of utility in functional investigation of GWAS-associated regions.
Zero-static power radio-frequency switches based on MoS2 atomristors
Authors: Kim Myungsoo , Ge Ruijing , Wu Xiaohan , Lan Xing , Tice Jesse , Lee Jack C. , Akinwande Deji
Published: June 2018

Recently, non-volatile resistance switching or memristor (equivalently, atomristor in atomic layers) effect was discovered in transitional metal dichalcogenides (TMD) vertical devices. Owing to the monolayer-thin transport and high crystalline quality, ON-state resistances below 10 Ω are achievable, making MoS2 atomristors suitable as energy-efficient radio-frequency (RF) switches. MoS2 RF switches afford zero-hold voltage, hence, zero-static power dissipation, overcoming the limitation of transistor and mechanical switches. Furthermore, MoS2 switches are fully electronic and can be integrated on arbitrary substrates unlike phase-change RF switches. High-frequency results reveal that a key figure of merit, the cutoff frequency (fc), is about 10 THz for sub-μm2 switches with favorable scaling that can afford fc above 100 THz for nanoscale devices, exceeding the performance of contemporary switches that suffer from an area-invariant scaling. These results indicate a new electronic application of TMDs as non-volatile switches for communication platforms, including mobile systems, low-power internet-of-things, and THz beam steering.
Natural selection of a GSK3 determines rice mesocotyl domestication by coordinating strigolactone and brassinosteroid signaling
Authors: Sun Shiyong , Wang Tao , Wang Linlin , Li Xiaoming , Jia Yancui , Liu Chang , Huang Xuehui , Xie Weibo , Wang Xuelu
Published: June 2018

Mesocotyl is the crucial organ for pushing buds out of deep water or soil after germination in monocots. Deep direct seeding or mechanized dry seeding cultivation practice requires rice cultivars having long mesocotyl. However, the mechanisms of mesocotyl elongation and domestication remain unknown. Here, our genome-wide association study (GWAS) reveals that natural variations of OsGSK2, a conserved GSK3-like kinase involved in brassinosteroid signaling, determine rice mesocotyl length variation. Variations in the coding region of OsGSK2 alter its kinase activity. It is selected for mesocotyl length variation during domestication. Molecular analyses show that brassinosteroid-promoted mesocotyl elongation functions by suppressing the phosphorylation of an U-type cyclin, CYC U2, by OsGSK2. Importantly, the F-box protein D3, a major positive component in strigolactone signaling, can degrade the OsGSK2-phosphorylated CYC U2 to inhibit mesocotyl elongation. Together, these results suggest that OsGSK2 is selected to regulate mesocotyl length by coordinating strigolactone and brassinosteroid signaling during domestication.
Very large tunneling magnetoresistance in layered magnetic semiconductor CrI3
Authors: Wang Zhe , Gutiérrez-Lezama Ignacio , Ubrig Nicolas , Kroner Martin , Gibertini Marco , Taniguchi Takashi , Watanabe Kenji , Imamoğlu Ataç , Giannini Enrico , Morpurgo Alberto F.
Published: June 2018

Magnetic layered van der Waals crystals are an emerging class of materials giving access to new physical phenomena, as illustrated by the recent observation of 2D ferromagnetism in Cr2Ge2Te6 and CrI3. Of particular interest in semiconductors is the interplay between magnetism and transport, which has remained unexplored. Here we report magneto-transport measurements on exfoliated CrI3 crystals. We find that tunneling conduction in the direction perpendicular to the crystalline planes exhibits a magnetoresistance as large as 10,000%. The evolution of the magnetoresistance with magnetic field and temperature reveals that the phenomenon originates from multiple transitions to different magnetic states, whose possible microscopic nature is discussed on the basis of all existing experimental observations. This observed dependence of the conductance of a tunnel barrier on its magnetic state is a phenomenon that demonstrates the presence of a strong coupling between transport and magnetism in magnetic van der Waals semiconductors.
Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict
Authors: Sweis Brian M. , Redish A. David , Thomas Mark J.
Published: June 2018

Neuroeconomic theories propose changes in decision making drive relapse in recovering drug addicts, resulting in continued drug use despite stated wishes not to. Such conflict is thought to arise from multiple valuation systems dependent on separable neural components, yet many neurobiology of addiction studies employ only simple tests of value. Here, we tested in mice how prolonged abstinence from different drugs affects behavior in a neuroeconomic foraging task that reveals multiple tests of value. Abstinence from repeated cocaine and morphine disrupts separable decision-making processes. Cocaine alters deliberation-like behavior prior to choosing a preferred though economically unfavorable offer, while morphine disrupts re-evaluations after rapid initial decisions. These findings suggest that different drugs have long-lasting effects precipitating distinct decision-making vulnerabilities. Our approach can guide future refinement of decision-making behavioral paradigms and highlights how grossly similar behavioral maladaptations may mask multiple underlying, parallel, and dissociable processes that treatments for addiction could potentially target.
Lacrimal Canaliculus Imaging Using Optical Coherence Tomography Dacryography
Authors: Fujimoto Masahiro , Uji Akihito , Ogino Ken , Akagi Tadamichi , Yoshimura Nagahisa
Published: June 2018

Lacrimal canaliculus (LC) has a key role in tear drainage, but it is difficult to evaluate the LC in detail, using the existing examinations. In this study, our novel LC imaging technique provided the high-resolution images of LC in a non-invasive manner. Three-dimensional images of LC were acquired via the palpebral conjunctiva from 20 healthy volunteers (20 eyes) and 10 patients with various lacrimal disorders (10 eyes), using optical coherence tomography (OCT) dacryography (OCTD). The LC images showed morphological differences between the vertical and horizontal segments. The function of LC could be evaluated by measuring the intralumen signal intensity over time after instillation of a contrast agent (2% rebamipide ophthalmic suspension). OCTD clearly visualised the blind extremity of the LC in four patients with punctal obstruction, which was useful for deciding the punctal incision location. In one patient with canalicular obstruction, contrast agent successfully highlighted the LC that had become narrow toward the site of obstruction. Significant differences were not found in the function and morphology of LC between the patients with NLDO and the healthy subjects. OCTD may be a useful tool for LC imaging, because it facilitates quantitative and simultaneous evaluation of LC morphology and function.
Evaluating the Contribution of North American Zoos and Aquariums to Endangered Species Recovery
Authors: Che-Castaldo Judy P. , Grow Shelly A. , Faust Lisa J.
Published: June 2018

The challenge of recovering threatened species necessitates collaboration among diverse conservation partners. Zoos and aquariums have long partnered with other conservation organizations and government agencies to help recover species through a range ofin situandex situconservation projects. These efforts tend to be conducted by individual facilities and for individual species, and thus the scope and magnitude of these actions at the national level are not well understood. Here we evaluate the means and extent to which North American zoos and aquariums contribute to the recovery of species listed under the U.S. Endangered Species Act (ESA), by synthesizing data from federal recovery plans for listed species and from annual surveys conducted by the Association of Zoos and Aquariums. We found that in addition to managingex situassurance populations, zoos frequently conduct conservation research and field-based population monitoring and assessments. Cooperatively managed populations in zoos tend to focus on species that are not listed on the ESA or on foreign listings, and thus it may be beneficial for zoos to manage more native threatened species. Our results highlight the existing contributions, but also identify additional opportunities for the zoo community to help recover threatened species.
Motion cues tune social influence in shoaling fish
Authors: Lemasson Bertrand , Tanner Colby , Woodley Christa , Threadgill Tammy , Qarqish Shea , Smith David
Published: June 2018

Social interactions have important consequences for individual fitness. Collective actions, however, are notoriously context-dependent and identifying how animals rapidly weigh the actions of others despite environmental uncertainty remains a fundamental challenge in biology. By exposing zebrafish (Danio rerio) to virtual fish silhouettes in a maze we isolated how the relative strength of a visual feature guides individual directional decisions and, subsequently, tunes social influence. We varied the relative speed and coherency with which a portion of silhouettes adopted a direction (leader/distractor ratio) and established that solitary zebrafish display a robust optomotor response to follow leader silhouettes that moved much faster than their distractors, regardless of stimulus coherency. Although recruitment time decreased as a power law of zebrafish group size, individual decision times retained a speed-accuracy trade-off, suggesting a benefit to smaller group sizes in collective decision-making. Directional accuracy improved regardless of group size in the presence of the faster moving leader silhouettes, but without these stimuli zebrafish directional decisions followed a democratic majority rule. Our results show that a large difference in movement speeds can guide directional decisions within groups, thereby providing individuals with a rapid and adaptive means of evaluating social information in the face of uncertainty.
Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress
Authors: Sigaut Lorena , von Bilderling Catalina , Bianchi Micaela , Burdisso Juan Eduardo , Gastaldi Laura , Pietrasanta Lía Isabel
Published: June 2018

Mechanical stimuli play a key role in many cell functions such as proliferation, differentiation and migration. In the mammary gland, mechanical signals such as the distension of mammary epithelial cells due to udder filling are proposed to be directly involved during lactation and involution. However, the evolution of focal adhesions -specialized multiprotein complexes that mechanically connect cells with the extracellular matrix- during the mammary gland development, as well as the influence of the mechanical stimuli involved, remains unclear. Here we present the use of an equibiaxial stretching device for exerting a sustained normal strain to mammary epithelial cells while quantitatively assessing cell responses by fluorescence imaging techniques. Using this approach, we explored changes in focal adhesion dynamics in HC11 mammary cells in response to a mechanical sustained stress, which resembles the physiological stimuli. We studied the relationship between a global stress and focal adhesion assembly/disassembly, observing an enhanced persistency of focal adhesions under strain as well as an increase in their size. At a molecular level, we evaluated the mechanoresponses of vinculin and zyxin, two focal adhesion proteins postulated as mechanosensors, observing an increment in vinculin molecular tension and a slower zyxin dynamics while increasing the applied normal strain.
HPV infection and bacterial microbiota in the placenta, uterine cervix and oral mucosa
Authors: Tuominen Heidi , Rautava Samuli , Syrjänen Stina , Collado Maria Carmen , Rautava Jaana
Published: June 2018

We investigated the association between HPV infection and bacterial microbiota composition in the placenta, uterine cervix and mouth in thirty-nine women. HPV DNA genotyping of 24 types was conducted using Multimetrix®. Microbiota composition was characterized by 16S rRNA gene sequencing. HPV DNA was detected in 33% of placenta, 23% cervical and 33% oral samples. HPV16 was the most frequent type in all regions. HPV infection was associated with higher microbiota richness (p = 0.032) in the mouth but did not influence microbial diversity or richness in other samples. HPV infection was associated with higher abundance of Lactobacillaceae (p = 0.0036) and Ureaplasma (LDA score > 4.0, p < 0.05) in the placenta, Haemophilus (p = 0.00058) and Peptostreptococcus (p = 0.0069) genus in the cervix and Selenomonas spp. (p = 0.0032) in the mouth compared to HPV negative samples. These data suggest altered bacterial microbiota composition in HPV positive placenta, cervix and mouth. Whether the changes in bacterial microbiota predispose or result from HPV remains to be determined in future studies.
Mechanism Underlying Green Discolouration of Myoglobin Induced by Atmospheric Pressure Plasma
Authors: Yong Hae In , Han Mookyoung , Kim Hyun-Joo , Suh Jeong-Yong , Jo Cheorun
Published: June 2018

In this study, we elucidated the mechanism underlying atmospheric pressure plasma (APP)-induced green discolouration of myoglobin. Green-coloured pigments are produced upon conversion of myoglobin into sulphmyoglobin, choleglobin, verdoheme, nitrihemin, or nitrimyoglobin. We exposed myoglobin dissolved in phosphate buffer to APP for 20 min and found a decrease in a* value (+redness/−greenness) and increase in b* value (+yellowness/−blueness) (P < 0.05). In the ultraviolet absorption spectrum, myoglobin treated with APP for 20 min showed absorption peaks at 503 and 630 nm, a spectrum different from that of sulphmyoglobin or choleglobin. The secondary structure and molecular weight of myoglobin were unaffected by APP treatment, excluding the possibility of verdoheme or nitrihemin formation. After APP treatment, nitrite was produced in myoglobin solution that provided a positive environment for nitrimyoglobin formation. However, the addition of 0.5% sodium dithionite, a strong reducing agent, to myoglobin solution resulted in the formation of deoxymyoglobin, which was subsequently converted to nitrosomyoglobin upon APP treatment to yield a desirable red colour. Thus, APP-induced green colouration in myoglobin solution is associated with nitrimyoglobin formation. The addition of the antioxidant resulted in the production of red colour in myoglobin solution after APP treatment owing to nitrosomyoglobin formation.
Arabidopsis mutants impaired in glutathione biosynthesis exhibit higher sensitivity towards the glucosinolate hydrolysis product allyl-isothiocyanate
Authors: Urbancsok János , Bones Atle M. , Kissen Ralph
Published: June 2018

Upon tissue damage the plant secondary metabolites glucosinolates can generate various hydrolysis products, including isothiocyanates (ITCs). Their role in plant defence against insects and pest and their potential health benefits have been well documented, but our knowledge regarding the endogenous molecular mechanisms of their effect in plants is limited. Here we investigated the effect of allyl-isothiocyanate (AITC) on Arabidopsis thaliana mutants impaired in homeostasis of the low-molecular weight thiol glutathione. We show that glutathione is important for the AITC-induced physiological responses, since mutants deficient in glutathione biosynthesis displayed a lower biomass and higher root growth inhibition than WT seedlings. These mutants were also more susceptible than WT to another ITC, sulforaphane. Sulforaphane was however more potent in inhibiting root growth than AITC. Combining AITC with the glutathione biosynthesis inhibitor L-buthionine-sulfoximine (BSO) led to an even stronger phenotype than observed for the single treatments. Furthermore, transgenic plants expressing the redox-sensitive fluorescent biomarker roGFP2 indicated more oxidative conditions during AITC treatment. Taken together, we provide genetic evidence that glutathione plays an important role in AITC-induced growth inhibition, although further studies need to be conducted to reveal the underlying mechanisms.
Evaluation of Performance Parameters of the Disposable Flexible Ureterorenoscope (LITHOVUE) in Patients with Renal Stones: A Prospective, Observational, Single-arm, Multicenter Study
Authors: Cho Sung Yong , Lee Joo Yong , Shin Dong Gil , Seo Ill Young , Yoo Sangjun , Park Hyung Keun
Published: June 2018

We investigated performance parameters of disposable flexible ureterorenoscopy (LITHOVUE) in patients with renal stones in a prospective, multicenter, observational study. Sixty two patients who underwent ureterorenoscopic surgery by LITHOVUE were included. Surgeons using a numerical scale, evaluated the maneuverability of the scopes and general perceptions of visibility related to the monitor and irrigation systems. General pain and fatigue scores were evaluated and compared to existing scopes. Mean patient age was 57.3 years and stone size was 15.4 mm. Clinical success of overall stone removal was 82.3%. Complications occurred in 4 cases of the Clavien classification grade I in a single case and II in 3 cases. Comparative parameters of maneuverability, perception of the monitor system and perception of the irrigation channel were 2.5, 2.5, and 3.0, respectively. The most favorable evaluation of physical strain was about ‘shoulder fatigue’ and ‘hand fatigue’. Unfavorable evaluations were recorded for ‘wrist stiffness’ and ‘thumb fatigue’. Maximal deflection angles of 270° were preserved in 53 cases (85.5%). No pre-stenting procedure and the longer operative time were significant predictors of poorly-preserved deflection angles <270°. LITHOVUE showed good maneuverability and perception scores for the monitor and irrigation systems. LITHOVUE received favorable evaluations on pain and fatigue scores.
An optimised quadrupole mass spectrometer with a dual filter analyser for in-field chemical sniffing of volatile organic compounds
Authors: Brkić Boris , France Neil , Giannoukos Stamatios , Taylor Stephen
Published: June 2018

A novel portable quadrupole mass spectrometer with an optimised dual filter analyser.
Ca2+, redox, and thermoresponsive supramolecular hydrogel with programmed quadruple shape memory effect
Authors: Tang Linya , Wen Lanfang , Xu Shouping , Pi Pihui , Wen Xiufang
Published: June 2018

With a new redox-responsive stimulus coupled with two other common regulation mechanisms, this hydrogel shows programmed quadruple shape memory behaviour.
A robust two-dimensional zirconium-based luminescent coordination polymer built on a V-shaped dicarboxylate ligand for vapor phase sensing of volatile organic compounds
Authors: Du Pei-Yao , Lustig William P. , Teat Simon J. , Gu Wen , Liu Xin , Li Jing
Published: June 2018

We report herein a new two-dimensional zirconium-based luminescent coordination polymer exhibiting selective fluorescence responses towards a variety of volatile organic compounds upon exposure in the vapor phase.
Tailoring the components and morphology of discharge products towards highly rechargeable Li–CO/CO2 batteries
Authors: Ma Shiyu , Yao Hongchang , Lei Dongling , Guo Xiaoqing , Lu Youcai , Liu Qingchao , Li Zhongjun
Published: June 2018

Herein, a new Li–CO/CO2 battery system with high capacity, superior round-trip efficiency and excellent cycling stability is proposed.
Unusual high-temperature reversible phase transition containing dielectric and nonlinear optical switches in host–guest supramolecular crown ether clathrates
Authors: Wei Yan-Li , Jing Jing , Shi Chao , Ye Heng-Yun , Wang Zhong-Xia , Zhang Yi
Published: June 2018

[(C6H5NF2)(18-crown-6)][HClO4] is a novel high-temperature dielectric and nonlinear optical switching material based on crown ether clathrates.
Ultrafast proton-assisted tunneling through ZrO2 in dye-sensitized SnO2-core/ZrO2-shell films
Authors: Swierk John R. , McCool Nicholas S. , Röhr Jason A. , Hedström Svante , Konezny Steven J. , Nemes Coleen T. , Xu Pengtao , Batista Victor S. , Mallouk Thomas E. , Schmuttenmaer Charles A.
Published: June 2018

Exposing ZrO2 to strong acid induces protonic defects that permit ultrafast electron transfer through at least 4 nm of ZrO2.