bluuebunny/crossref_metadata_2025 huggingface dataset:
Lights and Shadows of TORCH Infection Proteomics
Authors: Macedo-da-Silva Janaina , Marinho Claudio Romero Farias , Palmisano Giuseppe , Rosa-Fernandes Livia
Published: August 2020

Congenital abnormalities cause serious fetal consequences. The term TORCH is used to designate the most common perinatal infections, where: (T) refers to toxoplasmosis, (O) means “others” and includes syphilis, varicella-zoster, parvovirus B19, zika virus (ZIKV), and malaria among others, (R) refers to rubella, (C) relates to cytomegalovirus infection, and (H) to herpes simplex virus infections. Among the main abnormalities identified in neonates exposed to congenital infections are central nervous system (CNS) damage, microcephaly, hearing loss, and ophthalmological impairment, all requiring regular follow-up to monitor its progression. Protein changes such as mutations, post-translational modifications, abundance, structure, and function may indicate a pathological condition before the onset of the first symptoms, allowing early diagnosis and understanding of a particular disease or infection. The term “proteomics” is defined as the science that studies the proteome, which consists of the total protein content of a cell, tissue or organism in a given space and time, including post-translational modifications (PTMs) and interactions between proteins. Currently, quantitative bottom-up proteomic strategies allow rapid and high throughput characterization of complex biological mixtures. Investigating proteome modulation during host–pathogen interaction helps in elucidating the mechanisms of infection and in predicting disease progression. This “molecular battle” between host and pathogen is a key to identify drug targets and diagnostic markers. Here, we conducted a survey on proteomic techniques applied to congenital diseases classified in the terminology “TORCH”, including toxoplasmosis, ZIKV, malaria, syphilis, human immunodeficiency virus (HIV), herpes simplex virus (HSV) and human cytomegalovirus (HCVM). We have highlighted proteins and/or protein complexes actively involved in the infection. Most of the proteomic studies reported have been performed in cell line models, and the evaluation of tissues (brain, muscle, and placenta) and biofluids (plasma, serum and urine) in animal models is still underexplored. Moreover, there are a plethora of studies focusing on the pathogen or the host without considering the triad mother-fetus-pathogen as a dynamic and interconnected system.
Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case–Control Association Study
Authors: Almeida Joana T. , Rodrigues Dircea , Guimarães Joana , Lemos Manuel C.
Published: August 2020

Vitamin D has immunomodulatory effects, and its deficiency has been implicated in the autoimmune process of type 1 diabetes. Serum vitamin D levels are influenced by variants in genes involved in the synthesis, transport, hydroxylation and degradation of vitamin D. The aim of this study was to assess if single nucleotide polymorphisms (SNPs) at the DHCR7 (rs12785878), GC (rs2282679), CYP2R1 (rs2060793) and CYP24A1 (rs6013897) loci are associated with type 1 diabetes in the Portuguese population. Genotype and allele frequencies were determined in 350 cases of type 1 diabetes and in 490 controls. The frequency of each SNP alone was not significantly different between patients and controls. However, the combined analysis of the four SNPs showed that minor alleles of these variants clustered more frequently in patients. The proportion of individuals with three or more minor alleles was significantly higher in patients than in controls (56.3% vs. 48.5; odds ratio (OR) 1.37; 95% confidence interval (CI) 1.04–1.81; p-value 0.027). These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway.
Seismic Reflection Methods in Offshore Groundwater Research
Authors: Bertoni Claudia , Lofi Johanna , Micallef Aaron , Moe Henning
Published: August 2020

There is growing evidence that passive margin sediments in offshore settings host large volumes of fresh and brackish water of meteoric origin in submarine sub-surface reservoirs. Marine geophysical methods, in particular seismic reflection data, can help characterize offshore hydrogeological systems and yet the existing global database of industrial basin wide surveys remains untapped in this context. In this paper we highlight the importance of these data in groundwater exploration, by reviewing existing studies that apply physical stratigraphy and morpho-structural interpretation techniques to provide important information on—reservoir (aquifer) properties and architecture, permeability barriers, paleo-continental environments, sea-level changes and shift of coastal facies through time and conduits for water flow. We then evaluate the scientific and applied relevance of such methodology within a holistic workflow for offshore groundwater research.
Use of Teleconnections to Predict Western Australian Seasonal Rainfall Using ARIMAX Model
Authors: Islam Farhana , Imteaz Monzur Alam
Published: August 2020

Increased demand for engineering propositions to forecast rainfall events in an area or region has resulted in developing different rainfall prediction models. Interestingly, rainfall is a very complicated natural system that requires consideration of various attributes. However, regardless of the predictability performance, easy to use models have always been welcomed over the complex and ambiguous alternatives. This study presents the development of Auto–Regressive Integrated Moving Average models with exogenous input (ARIMAX) to forecast autumn rainfall in the South West Division (SWD) of Western Australia (WA). Climate drivers such as Indian Ocean Dipole (IOD) and El Nino Southern Oscillation (ENSO) were used as predictors. Eight rainfall stations with 100 years of continuous data from two coastal regions (south coast and north coast) were selected. In the south coast region, Albany (0,1,1) with exogenous input DMIOct–Nino3Nov, and Northampton (0,1,1) with exogenous input DMIJan–Nino3Nov were able to forecast autumn rainfall 4 months and 2 months in advance, respectively. Statistical performance of the ARIMAX model was compared with the multiple linear regression (MLR) model, where for calibration and validation periods, the ARIMAX model showed significantly higher correlations (0.60 and 0.80, respectively), compared to the MLR model (0.44 and 0.49, respectively). It was evident that the ARIMAX model can predict rainfall up to 4 months in advance, while the MLR has shown strict limitation of prediction up to 1 month in advance. For WA, the developed ARIMAX model can help to overcome the difficulty in seasonal rainfall prediction as well as its application can make an invaluable contribution to stakeholders’ economic preparedness plans.
Synthetic Bone Grafting in Aseptic Loosening of Acetabular Cup: Good Clinical and Radiological Outcomes in Contained Bone Defects at Medium-Term Follow Up
Authors: Parchi Paolo Domenico , Simonetti Matteo , Bonicoli Enrico , Piolanti Nicola , Scaglione Michelangelo
Published: August 2020

Restoring bone loss is one of the major challenges when facing hip revision surgery. To eliminate the risk of disease transmission and antigenicity of allografts and donor-morbidity of autografts, the use of synthetic bioceramics has become popular in the last decade. Our study investigated the effectiveness of impaction bone grafting (IBG) of contained acetabular defects (Paprosky 2 and 3a) using a porous ceramic-based hydroxyapatite bone substitute (Engipore, provided by Finceramica Faenza S.p.A., Faenza, Italy) mixed with a low percentage of autologous bone (obtained from reaming when available). We retrospectively assessed 36 patients who underwent acetabular revision using IBG using a porous ceramic-based hydroxyapatite bone substitute with cementless implants with a mean follow-up of 4.4 years. We evaluated, at regular intervals, patients clinically (using the Hip Harris Score and Oxford Score) and radiologically to evaluate the rate of incorporation of the graft, the presence of radiolucent lines or migrations of the cup. Clinical scores significantly improved (WOMAC improved from 49.7–67.30, and the HSS from 56–89). The rate of implants’ survival was 100% at our medium follow-up (4.4 years). We reported five cases of minor migration of the cup, and radiolucent lines were visible in seven patients at the last-follow up. The graft was well-incorporated in all patients. The results presented in this study suggest the HA bone substitute is an effective and safe bone graft when facing hip revision surgery; thus, longer follow-up studies are required.
Physical Activity Counseling in Primary Care in Germany—An Integrative Review
Authors: Füzéki Eszter , Weber Theresa , Groneberg David A. , Banzer Winfried
Published: August 2020

Physical activity counseling in primary health care is regarded as a useful complementary preventive and therapeutic measure and is advocated by leading public health institutions. This integrative review summarizes the available data on physical activity counseling in primary care in Germany. A systematic literature search in various databases (peer reviewed and grey literature) was carried out for quantitative and qualitative studies on physical activity counseling and use of “Exercise on Prescription”. The 25 studies included show a very high methodological diversity and, in some cases, considerable risks of bias, with limited comparability across studies. Counseling was provided in all studies by physicians. They report frequent physical activity counseling, which is partly confirmed and partly refuted by patient data. The use of “Exercise on Prescription” is at a very low level. Information on the frequency of physical activity counseling in Germany varies depending on data source and is sometimes contradictory. Our review provides a synthesis of various perspectives on routine physical activity counseling in primary care in Germany. Future studies using standardized and validated instruments in representative samples are needed to further knowledge on counseling and to be able to establish trends in prevalence. Strengthening the topics of physical activity and health and physical activity counseling in medical curriculum is strongly recommended.
Factors Associated with Mental Health Results among Workers with Income Losses Exposed to COVID-19 in China
Authors: Li Xin , Lu Peixin , Hu Lianting , Huang Tianhui , Lu Long
Published: August 2020

The outbreak and worldwide spread of COVID-19 has resulted in a high prevalence of mental health problems in China and other countries. This was a cross-sectional study conducted using an online survey and face-to-face interviews to assess mental health problems and the associated factors among Chinese citizens with income losses exposed to COVID-19. The degrees of the depression, anxiety, insomnia, and distress symptoms of our participants were assessed using the Chinese versions of the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Insomnia Severity Index-7 (ISI-7), and the revised 7-item Impact of Event Scale (IES-7) scales, respectively, which found that the prevalence rates of depression, anxiety, insomnia, and distress caused by COVID-19 were 45.5%, 49.5%, 30.9%, and 68.1%, respectively. Multivariable logistic regression analysis was performed to identify factors associated with mental health outcomes among workers with income losses during COVID-19. Participants working in Hubei province with heavy income losses, especially pregnant women, were found to have a high risk of developing unfavorable mental health symptoms and may need psychological support or interventions.
Association between Social Trust and Metabolic Syndrome in a Previously Healthy Population—A Longitudinal Cohort Study in South Korea
Authors: Park Hyeah , Choi Seulggie , Kim Kyae Hyung , Kang EunKyo , Ko Ahryoung , Park Sang Min
Published: August 2020

Background: Social trust, assessed by the trustworthiness of one another in a community, is known to have beneficial effects on health outcomes. However, the impact of social trust on metabolic syndrome (MetS) is unclear. Methods: The study subjects were extracted from the Korean National Health Insurance Service, and social trust was obtained from the Korean Community Health Survey (KCHS). Previously healthy participants were followed up from 1 January 2010 to 31 December 2011, and again from 1 January 2012 to 31 December 2013 for waist circumference, blood pressure, fasting blood glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C). Multivariate logistic regression was used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for newly developed MetS according to social trust quintiles. Stratified analyses were performed to determine the relationship between lifestyle behaviors and social trust. Results: Compared to the participants within the first quintile of social trust, those in the remaining quintiles had lower risks of developing MetS. The aOR with the 95% CI was 0.88 (0.79–0.98) in the 5th quintile group of social trust. Among the diagnostic criteria for MetS, waist circumference and HDL-C were statistically significant with aORs of 0.91 (0.84–0.99) and 0.88 (0.80–0.95) in the 5th quintile group. The stratified analyses showed protective effects of positive lifestyle behaviors. The aORs with 95% CIs were 0.85 (0.74–0.99) in never smokers, 0.82 (0.70–0.95) in non-drinkers and 0.87 (0.76–1.00) in the physically active in the highest level of social trust. Conclusions: Higher social trust was associated with a lower incidence of MetS. Therefore, building community with psychosocial support may be helpful in improving public health.
An Acceleration Based Fusion of Multiple Spatiotemporal Networks for Gait Phase Detection
Authors: Zhen Tao , Yan Lei , Kong Jian-lei
Published: August 2020

Human-gait-phase-recognition is an important technology in the field of exoskeleton robot control and medical rehabilitation. Inertial sensors with accelerometers and gyroscopes are easy to wear, inexpensive and have great potential for analyzing gait dynamics. However, current deep-learning methods extract spatial and temporal features in isolation—while ignoring the inherent correlation in high-dimensional spaces—which limits the accuracy of a single model. This paper proposes an effective hybrid deep-learning framework based on the fusion of multiple spatiotemporal networks (FMS-Net), which is used to detect asynchronous phases from IMU signals. More specifically, it first uses a gait-information acquisition system to collect IMU sensor data fixed on the lower leg. Through data preprocessing, the framework constructs a spatial feature extractor with CNN module and a temporal feature extractor, combined with LSTM module. Finally, a skip-connection structure and the two-layer fully connected layer fusion module are used to achieve the final gait recognition. Experimental results show that this method has better identification accuracy than other comparative methods with the macro-F1 reaching 96.7%.
Can the Neuromuscular Performance of Young Athletes Be Influenced by Hormone Levels and Different Stages of Puberty?
Authors: Almeida-Neto Paulo Francisco de , de Matos Dihogo Gama , Pinto Vanessa Carla Monteiro , Dantas Paulo Moreira Silva , Cesário Tatianny de Macêdo , da Silva Luíz Felipe , Bulhões-Correia Alexandre , Aidar Felipe José , Cabral Breno Guilherme de Araújo Tinôco
Published: August 2020

Background: Endocrine mechanisms can be a determining factor in the neuromuscular performance of young athletes. Objective: The objective of the present study was to relate maturational and hormonal markers to neuromuscular performance, as well as to verify whether young athletes with different testosterone levels show differences in muscle strength. Methods: The sample consisted of 37 young male Brazilian athletes (11.3 ± 0.94 years) who were members of a sports initiation project. Hormonal markers were analyzed biochemically by blood samples, and maturation markers by mathematical models based on anthropometry. Body composition was verified by tetrapolar bioimpedance. The performance of upper and lower limb strength and body speed were analyzed. Results: Hormonal and maturational markers were related to neuromuscular performance (p < 0.05). Young people with higher testosterone levels showed higher muscle strength (p < 0.05). Artificial neural networks showed that testosterone predicted the performance of upper limbs by 49%, and maturation by 60%. Maturation foreshadowed the performance of lower limbs by 30.3%. Conclusion: Biological maturation and hormonal levels can be related to neuromuscular performance, and young people with higher testosterone levels show superior muscle strength in relation to the others.
Bibliometric Profile of Global Microplastics Research from 2004 to 2019
Authors: Qin Fen , Du Jing , Gao Jian , Liu Guiying , Song Yonggang , Yang Aifu , Wang Hong , Ding Yuan , Wang Qian
Published: August 2020

Microplastics (MPs) have generated worldwide attention due to their global distribution in the environment, and their potential harmful effects on human and animal health. To analyze MPs-related scientific publications from a global point of view, we created a bibliometric profile, by searching the Web of Science Core Collection database for the topic “microplastic* or (micro near/1 plastic*)”, in publications dated from 2004 to 2019. The results revealed an increasing trend in publication output, and identified contributions of different countries and their collaborations, as well as influential authors and productive journals in the field of MPs research. Using co-citation network analysis in VOSviewer, we mined cited references for knowledge bases about analytical methods, potential sources and spatial distributions of MPs, the impacts of MPs on organisms, and the interaction of MPs with contaminants, as well as microorganisms. We also identified four global hotspots for MPs related research, using author keywords co-occurrence network analysis of all extracted publications, as well as Essential Science Indicators highly cited papers from Clarivate Analytics. Results of this study provide a valuable reference for ongoing MPs-related research, which may be of intrigue and awesome noteworthiness for relevant researchers.
Impact of the Sediment Organic vs. Mineral Content on Distribution of the Per- and Polyfluoroalkyl Substances (PFAS) in Lake Sediment
Authors: Mussabek Dauren , Persson Kenneth M. , Berndtsson Ronny , Ahrens Lutz , Nakagawa Kei , Imura Tomomi
Published: August 2020

Contamination of the water and sediment with per- and polyfluoroalkyl substances (PFAS) was studied for the lake impacted by the release of PFAS-containing aqueous film forming foam (AFFF). PFAS concentrations were analyzed in lake water and sediment core samples. ΣPFAS concentrations were in the range of 95–100 ng L−1 in the lake water and 3.0–61 µg kg−1 dry weight (dw) in sediment core samples, both dominated by perfluorohexane sulfonate, perfluorooctane sulfonate; 6:2 fluortelomer sulfonate was inconsistently present in water and sediment core samples. The sediment–water partitioning coefficients (log Kd) were estimated and ranged 0.6–2.3 L kg−1 for individual perfluoroalkyl carboxylates (PFCAs) and 0.9–5.6 L kg−1 for individual perfluoroalkane sulfonates (PFSAs). The influence of the sediment inorganic content and organic matter on PFAS distribution was investigated. In studied sediments, the mineral content (corresponding to <5% of the bulk media mass) was mainly represented by sulfur, iron and calcium. The PFAS distribution was found strongly connected to the sediment mineral content (i.e., Fe, Pb, Rb and As), whereas the sediment organic carbon content did not to have a direct influence on the PFAS distribution. The aim of this study was to improve our understanding of the PFAS distribution in the natural heterogeneous media.
The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials
Authors: Kato Michitaka , Nihei Green Fumi , Hotta Kazuki , Tsukamoto Toshiya , Kurita Yasunari , Kubo Akira , Takagi Hisato
Published: August 2020

Background: Aerobic exercise is known to reduce arterial stiffness; however, high-intensity resistance exercise is associated with increased arterial stiffness. Stretching exercises are another exercise modality, and their effect on arterial stiffness remains unclear. The purpose of this study was to determine whether stretching exercises reduce arterial stiffness in middle-aged and older adults, performing the first meta-analysis of currently available studies. Methods: We searched the literature for randomized controlled trials (RCTs) and non-RCTs published up to January 2020 describing middle-aged and older adults who participated in a stretching intervention vs. controls without exercise training. The primary and secondary outcomes were changes in arterial stiffness and vascular endothelial function and hemodynamic status. Pooled mean differences (MDs) and standard MDs (SMDs) with 95% confidence intervals (CIs) between the intervention and control groups were calculated using a random effects model. Results: We identified 69 trials and, after an assessment of relevance, eight trials, including a combined total of 213 subjects, were analyzed. Muscle stretching exercises were shown to significantly reduce arterial stiffness and improve vascular endothelial function (SMD: −1.00, 95% CI: −1.57 to −0.44, p = 0.0004; SMD: 1.15, 95% CI: 0.26 to 2.03, p = 0.01, respectively). Resting heart rate (HR) and diastolic blood pressure (DBP) decreased significantly after stretching exercise intervention (MD: −0.95 beats/min, 95% CI: −1.67 to −0.23 beats/min, p = 0.009; MD: −2.72 mm Hg, 95% CI: −4.01 to −1.43 mm Hg, p < 0.0001, respectively) Conclusions: Our analyses suggest that stretching exercises reduce arterial stiffness, HR, and DBP, and improve vascular endothelial function in middle-aged and older adults.
Consumption of Substances in Nightlife Settings: A Qualitative Approach in Young Andalusians (Spain)
Authors: García-Carpintero-Muñoz María Ángeles , Tarriño-Concejero Lorena , de Diego-Cordero Rocío
Published: August 2020

Adolescence and youth are stages of exploration and experimentation, when the consumption of psychoactive substances for recreational or experimental purposes often begins. The general objective of this study was to explore youth consumption habits in nightlife settings and associated factors in Andalusia (Spain). To this end, we took into account young people’s perceptions about patterns of drug polyconsumption in nightlife settings and the perceptions and actions of health and teaching professionals towards this issue. We carried out a qualitative methodology with 24 in-depth interviews and 3 discussion groups with Andalusian girls and boys aged between 16 and 22 (n = 45) and 13 in-depth interviews with social agents (health and teaching professionals). We performed narrative discourse analysis and triangulation of identified categories and measured the units of analysis. The results show information relating to gender, age of initiation, most commonly consumed substances, motivation and effects, peer group pressure and how they obtained the substances, and the perceptions held and main activities carried out in the educational institutions and health centers.
The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting
Authors: Hozhabri Hossein , Piceci Sparascio Francesca , Sohrabi Hamidreza , Mousavifar Leila , Roy René , Scribano Daniela , De Luca Alessandro , Ambrosi Cecilia , Sarshar Meysam
Published: August 2020

Over the past two decades, there have been two major outbreaks where the crossover of animal Betacoronaviruses to humans has resulted in severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In December 2019, a global public health concern started with the emergence of a new strain of coronavirus (SARS-CoV-2 or 2019 novel coronavirus, 2019-nCoV) which has rapidly spread all over the world from its origin in Wuhan, China. SARS-CoV-2 belongs to the Betacoronavirus genus, which includes human SARS-CoV, MERS and two other human coronaviruses (HCoVs), HCoV-OC43 and HCoV-HKU1. The fatality rate of SARS-CoV-2 is lower than the two previous coronavirus epidemics, but it is faster spreading and the large number of infected people with severe viral pneumonia and respiratory illness, showed SARS-CoV-2 to be highly contagious. Based on the current published evidence, herein we summarize the origin, genetics, epidemiology, clinical manifestations, preventions, diagnosis and up to date treatments of SARS-CoV-2 infections in comparison with those caused by SARS-CoV and MERS-CoV. Moreover, the possible impact of weather conditions on the transmission of SARS-CoV-2 is also discussed. Therefore, the aim of the present review is to reconsider the two previous pandemics and provide a reference for future studies as well as therapeutic approaches.
The Impact of Device Settings, Use Patterns, and Flavorings on Carbonyl Emissions from Electronic Cigarettes
Authors: Son Yeongkwon , Weisel Clifford , Wackowski Olivia , Schwander Stephan , Delnevo Cristine , Meng Qingyu
Published: August 2020

Health impacts of electronic cigarette (e-cigarette) vaping are associated with the harmful chemicals emitted from e-cigarettes such as carbonyls. However, the levels of various carbonyl compounds under real-world vaping conditions have been understudied. This study evaluated the levels of carbonyl compounds (e.g., formaldehyde, acetaldehyde, glyoxal, and diacetyl, etc.) under various device settings (i.e., power output), vaping topographies, and e-liquid compositions (i.e., base liquid, flavor types). The results showed that e-vapor carbonyl levels were the highest under higher power outputs. The propylene glycol (PG)-based e-liquids generated higher formaldehyde and acetaldehyde than vegetable glycerin (VG)-based e-liquids. In addition, fruit flavored e-liquids (i.e., strawberry and dragon fruit) generated higher formaldehyde emissions than mint/menthol and creamy/sweet flavored e-liquids. While single-top coils formed 3.5-fold more formaldehyde per puff than conventional cigarette smoking, bottom coils generated 10–10,000 times less formaldehyde per puff. In general, increases in puff volume and longer puff durations generated significantly higher amounts of formaldehyde. While e-cigarettes emitted much lower levels of carbonyl compounds compared to conventional cigarettes, the presence of several toxic carbonyl compounds in e-cigarette vapor may still pose potential health risks for users without smoking history, including youth. Therefore, the public health administrations need to consider the vaping conditions which generated higher carbonyls, such as higher power output with PG e-liquid, when developing e-cigarette product standards.
Temporal Association between Abdominal Weight Status and Healthy Aging: Findings from the 2011–2018 National Health and Aging Trends Study
Authors: Xu Furong , Earp Jacob E. , Greene Geoffrey W. , Cohen Steven A. , Lofgren Ingrid E. , Delmonico Matthew J. , Greaney Mary L.
Published: August 2020

Background/objectives: The longitudinal effect of abdominal weight status (AWS) defined by waist circumference (WC) on healthy aging has not yet been comprehensively examined. Therefore, the purpose of the present study was to examine the temporal association between WC-defined AWS and a comprehensive assessment for healthy aging. Subjects/methods: This study utilized data from 5211 respondents aged 65+ who participated in the National Health and Aging Trends Study from 2011 to 2018. Mixed effects regression models were used to examine the association between baseline AWS and the annual change rate in healthy aging score (HAS) via interaction terms (AWS*round) adjusting for confounding effects. Further multiple mixed models examined the relationship of AWS and HAS over an 8-year period. Results: There were no annual change rate differences in HAS by baseline AWS, regardless of sex. However, males with abdominal obesity were more likely to have a lower HAS than males with normal AWS (β = −0.20, 95% CI: −0.30, −0.10, p < 0.001) but no difference in HAS was observed between males with overweight and normal AWS. A similar pattern was observed among females. Conclusions: Study results indicate that AWS was associated with HAS but it did not modify annual HAS change rate over time.
The Comparison of Perfectionism and Commitment between Professional and Amateur Golfers and the Association between Perfectionism and Commitment in the Two Groups
Authors: Nam Jae Jun , Han Doug Hyun
Published: August 2020

This study investigated differences in perfectionist traits and commitment between professional and amateur golfers, as well as correlations among perfectionist traits, commitment, and golf handicap. Using simple random sampling, 486 professional golfers (mean age = 22.1 ± 3.0, 52.1% female) and 233 amateur golfers (mean age = 44.8 ± 10.2, 55.8% female) were recruited and assessed using the Multidimensional Perfectionism Scale (MPS) and Expansion of Sports Commitment Model (ESCM). An ANCOVA, controlling for age, golf career length, and training time, revealed lower MPS self-oriented scores (10.3%; F = 8.9, p < 0.01; effect size [ES] = 0.498) and higher ESCM-Cognition (12.6%; F = 9.4, p < 0.01; ES = 0.691) and ESCM-Behavior (9.4%; F = 4.6, p = 0.03; ES = 0.479) scores in professional golfers than in amateur golfers. In partial correlations controlling for age, golf career length, and training time, professional golfers’ MPS scores were negatively associated with ESCM-Cognition scores (r = -0.30, p < 0.001). Professional golfers’ mean golf handicap was positively correlated with MPS total (r = 0.33, p < 0.01). Altogether, golfers seeking to attain high levels of performance must consider the mental aspect of golfing and find ways to maximize commitment levels while minimizing perfectionist traits.
Effect of Birdsong Soundscape on Perceived Restorativeness in an Urban Park
Authors: Zhao Wei , Li Hongyu , Zhu Xun , Ge Tianji
Published: August 2020

Natural soundscapes have beneficial effects on the perceived restorativeness of an environment. This study examines the effect of birdsong, a common natural soundscape, on perceived restorativeness in Harbin Sun Island Park in China. Eight sites were selected and a series of questionnaire surveys on perceived restorativeness soundscape scale (PRSS) of four birdsong types were conducted during summer and winter. Two-hundred and forty respondents participated in this survey. Analysis of the survey results shows that different types of birdsong have different perceived restorativeness effects in different seasons. Crow birdsong has the worst effect on the perceived restorativeness in both summer and winter. Moreover, sound comfort and preference are significantly associated with the perceived restorativeness. The perceived restorativeness soundscape is best when birdsong is at a height of 4 m rather than 0.5 m or 2 m. The demographic/social factors of age, education, and stress level are all correlated with perceived restorativeness. There are suggestions for urban park design, especially with constructed natural elements. Creating a suitable habitat for multiple species of birds will improve perceived restorativeness. Moreover, appropriate activities should be provided in city parks to ensure restorativeness environments, especially for subjects with high levels of education and stress.
Passive-Type Radon Monitor Constructed Using a Small Container for Personal Dosimetry
Authors: Tamakuma Yuki , Kranrod Chutima , Suzuki Takahito , Watanabe Yuki , Ploykrathok Thamaborn , Negami Ryoju , Nugraha Eka Djatnika , Iwaoka Kazuki , Janik Mirosław , Hosoda Masahiro , Tokonami Shinji
Published: August 2020

The International Commission on Radiological Protection (ICRP) recently recommended a new dose conversion factor for radon based on the latest epidemiological studies and dosimetric model. It is important to evaluate an inhalation dose from radon and its progeny. In the present study, a passive radon personal monitor was designed using a small container for storing contact lenses and its performance was evaluated. The conversion factor for radon (222Rn), the effect of thoron (220Rn) concentration and the air exchange rate were evaluated using the calibration chamber at Hirosaki University. The minimum and maximum detectable radon concentrations were calculated. The conversion factor was evaluated as 2.0 ± 0.3 tracks cm−2 per kBq h m−3; statistical analyses of results showed no significant effect from thoron concentration. The minimum and maximum detectable radon concentrations were 92 Bq m−3 and 231 kBq m−3 for a measurement period of three months, respectively. The air exchange rate was estimated to be 0.26 ± 0.16 h−1, whose effect on the measured time-integrated radon concentration was small. These results indicate that the monitor could be used as a wearable monitor for radon measurements, especially in places where radon concentrations may be relatively high, such as mines and caves.
Association between Allergic Rhinitis and Regular Physical Activity in Adults: A Nationwide Cross-Sectional Study
Authors: Park Jewel , Park Joo Hee , Park Jaehyung , Choi Jimi , Kim Tae Hoon
Published: August 2020

Evidence regarding the association between allergic rhinitis (AR) and physical activity (PA) is conflicting. Previous studies have mostly relied only on self-reported symptoms to define AR, did not classify AR by severity or persistence, and included only children or athletes. The present cross-sectional study evaluated the association between PA and objectively-defined AR and its subtypes in the general adult population using data for 1932 eligible participants aged 19 years or older in the 2010 Korea National Health and Nutrition Examination Survey. Multivariable logistic regression analyses were performed to evaluate the relationship between three types of PA and overall AR, AR subtypes, and rhinoscopy findings showed that moderate-severe AR was positively associated with vigorous (odds ratio [OR] = 3.392, p = 0.002) and moderate (OR = 3.623, p = 0.007) PA compared to mild AR, while persistent AR was associated with vigorous (OR = 3.954, p = 0.004) and moderate (OR = 3.411, p = 0.022) PA compared to intermittent AR. On rhinoscopy, vigorous PA was significantly associated with watery rhinorrhea (OR = 2.203, p = 0.048) but not pale mucosa. Total immunoglobulin E (IgE) and three allergen-specific IgE were not significantly elevated in participants who performed PA. Therefore, regular vigorous PA is associated with subjective and objective aggravation of AR symptoms, which may not necessarily manifest as increased serum IgE levels.
Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor
Authors: Zhang Chao , Schilirò Tiziana , Gea Marta , Bianchi Silvia , Spinello Angelo , Magistrato Alessandra , Gilardi Gianfranco , Di Nardo Giovanna
Published: August 2020

The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradiol, thiacloprid and imidacloprid induced an estrogenic activity at the highest concentrations tested with a relative potency of 5.4 × 10−10 and 3.7 × 10−9, respectively. Molecular dynamics and docking simulations predicted the potential binding sites and the binding mode of the three pesticides on the structure of the two key targets, providing a rational for their mechanism as EDCs. The results demonstrate that the three pesticides are potential EDCs as glyphosate acts as an aromatase inhibitor, whereas imidacloprid and thiacloprid can interfere with estrogen induced signaling.
Dementia-Free Life Expectancy among People over 60 Years Old by Sex, Urban and Rural Areas in Jiangxi Province, China
Authors: Wu Yuhang , Zheng Huilie , Liu Zhitao , Wang Shengwei , Liu Yong , Hu Songbo
Published: August 2020

Objective: To estimate and compare the dementia-free life expectancy (DemFLE) and age trends of the population over 60 in 2018 in Jiangxi Province, China, by sex and urban–rural areas. Methods: Based on the Summary of Health Statistics of Jiangxi Province in 2018 and the Sixth National Health Service survey of Jiangxi Province, the model life table is used to estimate the age-specific mortality rate by sex and urban–rural areas. DemFLE and its ratio to life expectancy (LE) were calculated using the Sullivan method. Results: In 2018, the DemFLE at age 60 was 18.48 years for men and 21.31 years for women, accounting for 96.62% and 96.67% of their LE. LE and DemFLE were higher for those in urban areas than in rural areas, except for men aged 90 and above; higher in women than in men, except for people in rural areas aged 90 and above. In urban areas, DemFLE/LE was higher for women than for men; the opposite was observed in rural areas. Urban women had a higher DemFLE/LE than rural women did, urban men had a lower DemFLE/LE than rural men did. Conclusions: With increased LE, DemFLE also increases, but with older age and over time, DemFLE/LE gradually decreases. The effect of dementia on elderly adults becomes more serious. It is necessary for the government to implement a series of prevention strategies to improve the quality of life and health awareness of the elderly. Elderly urban men and elderly rural women need more attention and health care.
Determination of Organochlorines in Soil of a Suburban Area of São Paulo Brazil
Authors: R. O. Varca Justine P. , A. J. Martins Elâine , H. C. Varca Gustavo , L. Romano Renato , T. Lebre Daniel , E. O. Lainetti Paulo , V. Bustillos José O.
Published: August 2020

Technological advances have promoted improvements in several science fields, especially related to environmental and analytical areas with the improvement of detection and development of environmentally friendly extraction techniques. This study applied Quick, Easy, Cheap, Effective, Rugged and Safe method (QuEChERS) for soil extraction and assessed its performance through a validation study using samples from the soil of a contaminated area in Caieiras, SP, Brazil. Nine organochlorine pesticides, including the isomers alpha, beta, gamma and delta- hexachlorocyclohexane; cis- and trans-heptachlor epoxide; cis- and trans-chlordane and heptachlor were analyzed by gas chromatography coupled to electron capture detector. The method was validated according to ISO 5725-4 (2020), EURACHEM (2014) and DOQ-CGCRE-008 (2016). The limits of detection and quantification of the method for the nine organochlorines were α-HCH (1.2 and 12.6 µg kg−1), β-HCH (1.7 and 12.0 µg kg−1), γ-HCH (1.5 and 11.6 µg kg−1), δ-HCH (0.8 and 11.6 µg kg−1), heptachlor (1.0 and 10.8 µg kg−1), cis-heptachlor epoxide (0.9 and 11.5 µg kg−1), trans-heptachlor epoxide (0.9 and 11.5 µg kg−1), cis-chlordane (0.4 and 7.9 µg kg−1) and trans-chlordane (0.5 and 10.9 µg kg−1), respectively, and all of them were within the maximum limits recommended by the EPA for the compounds α-HCH (86.0 and 360.0 µg kg−1), β-HCH (300.0 and 1.3 × 103 µg kg−1), γ-HCH (570.0 and 2.5 × 103 µg kg−1), δ-HCH (not defined), heptachlor (130.0 and 630.0 µg kg−1), cis-/trans-heptachlor epoxide (7.0 and 330.0 µg kg−1), cis-/trans-chlordane (1.77 × 103 and 7.7 × 103 µg kg−1) in residential and industrial soil, respectively. Recovery results were between 65% and 105% for almost all compounds, which is an optimum result for multi-residue analytical methods, considering the complexity of the matrix used in the study. Caieiras presented contamination levels of α-HCH in the range of 2.0 to 66.0 µg g−1, which was higher than the limits established by EPA, corresponding to 0.077 µg g−1 for residential soil and 0.27 µg g−1 for industrial soil. According to the validation study, the analytical method proposed was reliable for organochlorine quantification, and the QuEChERS was considered efficient for organochlorine extraction from soil.
Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma
Authors: Tantillo Elena , Colistra Antonella , Baroncelli Laura , Costa Mario , Caleo Matteo , Vannini Eleonora
Published: August 2020

Currently, high-grade gliomas are the most difficult brain cancers to treat and all the approved experimental treatments do not offer long-term benefits regarding symptom improvement. Epidemiological studies indicate that exercise decreases the risk of brain cancer mortality, but a direct relationship between physical exercise and glioma progression has not been established so far. Here, we exploited a mouse model of high-grade glioma to directly test the impact of voluntary physical exercise on the tumor proliferation and motor capabilities of affected animals. We report that exposing symptomatic, glioma-bearing mice to running wheels (i) reduced the proliferation rate of tumors implanted in the motor cortex and (ii) delayed glioma-induced motor dysfunction. Thus, voluntary physical exercise might represent a supportive intervention that complements existing neuro-oncologic therapies, contributing to the preservation of functional motor ability and counteracting the detrimental effects of glioma on behavioral output.
Residential Surrounding Greenspace and Mental Health in Three Spanish Areas
Authors: Torres Toda Maria , Anabitarte Riol Asier , Cirach Marta , Estarlich Marisa , Fernández-Somoano Ana , González-Safont Llúcia , Guxens Mònica , Julvez Jordi , Riaño-Galán Isolina , Sunyer Jordi , Dadvand Payam
Published: August 2020

Exposure to greenspace has been related to improved mental health, but the available evidence is limited and findings are heterogeneous across different areas. We aimed to evaluate the associations between residential exposure to greenspace and specific psychopathological and psychosomatic symptoms related to mental health among mothers from a Spanish birth cohort. Our study was based on data from 1171 women participating in two follow-ups of a population-based cohort in Valencia, Sabadell, and Gipuzkoa (2004–2012). For each participant, residential surrounding greenspace was estimated as the average of the satellite-based Normalized Difference Vegetation Index (NDVI) across different buffers around the residential address at the time of delivery and at the 4-year follow-up. The Symptom Checklist 90 Revised (SCL-90-R) was applied to characterize mental health at the 4-year follow-up. We developed mixed-effects logistic regression models controlled for relevant covariates to evaluate the associations. Higher residential surrounding greenspace was associated with a lower risk of somatization and anxiety symptoms. For General Severity Index (GSI), obsessive–compulsive, interpersonal sensitivity, depression, hostility, phobic anxiety, paranoid ideation, and psychoticism symptoms, we generally observed protective associations, but none attained statistical significance. Findings from this study suggested a potential positive impactof greenspace on mental health.
Performance and Obstacle Tracking to Natural Forest Resource Protection Project: A Rangers’ Case of Qilian Mountain, China
Authors: Wang Ya , Zhou Lihua , Yang Guojing , Guo Rui , Xia Cuizhen , Liu Yang
Published: August 2020

Forests play an important role in the process of land degradation and restoration. As a national key ecological project for protecting natural forest, the natural forest resource protection project was implemented in 17 provinces for nearly 20 years. As the core stakeholders and main force for protecting forest resources, rangers have a clear, more objective and comprehensive perception of the policy process, problems and forest ecological changes than farmers. This study introduces public value theory, builds a performance evaluation system that combines the “process-outcome” of ecological construction and uses the GRA-TOPSIS and obstacle tracking model to investigate the performance and obstacle factor of natural forest resource protection project from rangers’ perspective. GRA-TOPSIS is an optimal sequence technique for ideal solution optimization that combines the gray correlation method. The empirical results showed the overall performance of the natural forest resource protection project is good, the relative gray closeness that indicated the process dimension value of the natural forest resource protection project (NFRPP) is 0.663 which higher than the outcome dimension. It reflected the characterization and value level of overall and dimensions performance of NFRPP in Qilian Mountain. The rangers’ support evaluation is the highest, followed by the ecological outcome, sustainability and stability. The key obstacle is the support of local farmers, the social and economic outcome of the project. The natural forest resource protection project has shortcomings in its management system, function setting and support mechanism and urgently improved it from the resource system, resource unit, management system and user. These results are important to promote better implementation of such ecological projects, to enhance the project stability and the regional sustainable development.
Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore
Authors: Koga Hitomi , Negishi Mai , Kinoshita Marie , Fujii Shinya , Mori Shuichi , Ishigami-Yuasa Mari , Kawachi Emiko , Kagechika Hiroyuki , Tanatani Aya
Published: August 2020

First-generation nonsteroidal androgen receptor (AR) antagonists, such as flutamide (2a) and bicalutamide (3), are effective for most prostate cancer patients, but resistance often appears after several years due to the mutation of AR. Second-generation AR antagonists are effective against some of these castration-resistant prostate cancers, but their structural variety is still limited. In this study, we designed and synthesized 4-methyl-7-(N-alkyl-arylcarboxamido)coumarins as AR antagonist candidates and evaluated their growth-inhibitory activity toward androgen-dependent SC-3 cells. Coumarinamides with a secondary amide bond did not show inhibitory activity, but their N-methylated derivatives exhibited AR-antagonistic activity. Especially, 19b and 31b were more potent than the lead compound 7b, which was comparable to hydroxyflutamide (2b). Conformational analysis showed that the inactive coumarinamides with a secondary amide bond have an extended structure with a trans-amide bond, while the active N-methylated coumarinamides have a folded structure with a cis-amide bond, in which the two aromatic rings are placed face-to-face. Docking study suggested that this folded structure is important for binding to AR. Selected coumarinamide derivatives showed AR-antagonistic activity toward LNCaP cells with T877A AR, and they had weak progesterone receptor (PR)-antagonistic activity. The folded coumarinamide structure appears to be a unique pharmacophore, different from those of conventional AR antagonists.