bluuebunny/crossref_metadata_2025 huggingface dataset:
Fabrication of PES/PDMS/ZIF-L Composite Membrane for CO2, N2 and CH4 Permeation
Authors:   School of Chemical Engineering, Universiti Sains Malaysia Engineering Campus, 14300 Nibong Tebal, Pulau Pinang, Malaysia, Shah Buddin Meor Muhammad Hafiz ,   School of Chemical Engineering, College of Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia, Ahmad Abdul Latif ,   School of Chemical Engineering, Universiti Sains Malaysia Engineering Campus, 14300 Nibong Tebal, Pulau Pinang, Malaysia
Published: December 2022

This manuscript reports the fabrication of polyethersulfone (PES)/polydimethylsiloxane (PDMS)/zeolitic imidazolate framework (ZIF-L) composite membrane for gas separation. ZIF-L is a new type of nanosheet metal-organic frameworks that can selectively separate CO2. Hypothetically, its presence in the selective layer will simultaneously improve CO2 permeance and selectivity. The effect of four parameters (PDMS concentration, withdrawal speed, holding time and ZIF-L:PDMS ratio) involved during the fabrication process on the separation performance were thoroughly looked at. Except for ZIF-L:PDMS ratio, it was found that, all parameters have a significant influence on both, the thickness of selective layer and amount of ZIF-L present. ZIF-L:PDMS ratio has substantial impact on the ZIF-L adhered on the support. The ideal fabrication condition was 3 wt% PDMS concentration, 5 mm/s withdrawal speed, 120s holding time and 1:1 ZIF-L:PDMS ratio. At these conditions, the composite membrane recorded 4.25 GPU, 15.71 GPU and 8.93 GPU of CO2 permeance, CO2/N2 and CO2/CH4 selectivity, respectively.
Simulation of Pt80Au14Ti6 Work Function Change-Based Sensor of H2 Gas
Authors:   Department of Physics, Faculty of Mathematics and Natural Sciences, University of Lampung, Jl. Prof. Dr. Soemantri Brodjonegoro No.1, Bandar Lampung 35145, Indonesia, Marjunus Roniyus , Al Fath Yusril ,   Department of Physics, Faculty of Mathematics and Natural Sciences, University of Lampung, Jl. Prof. Dr. Soemantri Brodjonegoro No.1, Bandar Lampung 35145, Indonesia, Yulianti Yanti ,   Department of Physics, Faculty of Mathematics and Natural Sciences, University of Lampung, Jl. Prof. Dr. Soemantri Brodjonegoro No.1, Bandar Lampung 35145, Indonesia, Widanarto Wahyu ,   Department of Physics, Faculty of Mathematics and Natural Sciences, University of Jenderal Soedirman, Jl. Prof. Dr. HR Boenyamin No.708, Dukuhbandong, Grendeng, Kec. Purwokerto Utara, Kabupaten Banyumas 53122, Indonesia
Published: December 2022

Chemical reactions simulation in detecting hydrogen gas (H2) on Pt80Au14Ti6 sensor surface based on work function change (Δɸ) has been conducted. The simulation result is compared with laboratory results of detecting H2 gas. Three chemical reactions contained three coverages, H coverage (θH), O coverage (θO), and H2O coverage (θH2O). The simulation was run using MATLAB. This research can find the reaction parameter values such as the Arrhenius coefficient of H2O forming reaction on Pt (υf3Pt), H2O forming reaction on Au (υf3Au), i.e., H2O dissociation on Au (υf3Au ), O2 desorption on Ti (υd2Ti), H2O forming reaction on Ti (υf3Ti), and H2O dissociation on Ti (υf3Ti), i.e., 7.5×1014 s–1, 9.85×1015 s–1, 3.25×1015 s–1, 7.11×1015 s–1, 3.425×1015 s–1 and 2.725×1015 s–1, respectively. The simulation results also have the same trend as the laboratory results. However, the contact potential difference (CPD) simulation result, i.e., –240 mV, is not the same as the laboratory result, (–297± 9) mV. In addition, this simulation also obtained approximation coverage for atoms/molecules on PT80Au14Ti6 surface, i.e., θH = 0.665154 Mono Layer (ML); θO = 1.5621× 10–6 ML; and θH2O = 5.41676 ×10–5 ML.
Profesionalni stres, izgaranje i vikarijska trauma u socijalnome radu: smjernice za prevenciju i zaštitu mentalnog zdravlja socijalnih radnika
Authors:   Fakultet hrvatskih studija Sveučilišta u Zagrebu, Borongajska cesta 83d, 10 000 Zagreb, Vučenović Dario , Hajncl Ljerka ,   Pravni fakultet Osijek, Sveučilište J. J. Strossmayera u Osijeku, Ulica Stjepana Radića 13, 31 000 Osijek, Jelić Katarina ,   Fakultet hrvatskih studija Sveučilišta u Zagrebu, Borongajska cesta 83d, 10 000 Zagreb
Published: December 2022

Tolerancija stresa jedna je od karakteristika otpornih pojedinaca, a dugoročna izloženost stresu na radnome mjestu dovodi do sindroma profesionalnog izgaranja. Vikarijska trauma je ishod kontinuirane izloženosti traumi korisnika i vezana je uz direktan rad s ljudima. I dok se profesionalno izgaranje može pojaviti u svim područjima rada, za vikarijsku traumu specifično je da se pojavljuje samo kod praktičara čiji su korisnici žrtve ili rjeđe počinitelji nasilja. U radu su prikazani rizični i zaštitni čimbenici te mehanizmi koji pomažu predvidjeti koji će pojedinci biti podložniji simptomima vikarijske traume, o kojoj se nedovoljno sluša u programima osposobljavanja socijalnih radnika za rad s ranjivim skupinama korisnika. Ti čimbenici mogu biti osobni ili organizacijski. Zajedničko im je to da narušavaju produktivnost socijalnih radnika, njihovu predanost i zadovoljstvo poslom te sposobnost suosjećanja, a posljedice mogu utjecati i na njihov obiteljskih život. Ključne riječi: socijalni rad, vikarijska trauma, sekundarna trauma, izgaranje, stres
Aktivno uključivanje i posttraumatski rast hrvatskih branitelja u kriznim razdobljima
Authors:   Zdravstveno veleučilište Zagreb Mlinarska cesta 38, 10000 Zagreb, Pavić Jadranka
Published: December 2022

Iako su od završetka Domovinskog rata prošla gotovo tri desetljeća, hrvatski branitelji još uvijek se susreću s preprekama koje su uvjetovane, između ostalog, i raznim društvenim fenomenima koji su imali nepovoljan utjecaj na aktivnosti branitelja i njihov posttraumatski rast. Cilj rada je prikazati aktivnosti hrvatskih branitelja tijekom razdoblja pandemije i potresa u gradu Zagrebu i Banovini te njihove refleksije na posttraumatski rast branitelja. Sudionici istraživanja su hrvatski branitelji s invaliditetom koji su članovi udruga branitelja i koji su aktivno sudjelovali u pomoći sugrađanima i suborcima tijekom aktualne pandemije koronavirusa te potresa u gradu Zagrebu i Banovini. Istraživanje je pokazalo da su branitelji bili aktivno uključeni u psihološku podršku i osnaživanje sugrađana, prikupljanje i prijevoz potrebne pomoći te fizičku pomoć u obliku prikupljanja i dostave građevinskog materijala, kontejnera za stanovanje, kuhanja obroka, saniranja šteta od potresa, poput raščišćavanja ruševina, popravka krovišta i drugih fizičkih poslova. Takav aktivni oblik uključivanja u pomoć zajednici rezultirao je i poboljšanjem psihološke dobrobiti i osobnog rasta branitelja. U istraživanju je prikazano šest vodećih područja osobnog rasta koja su identificirana na osnovi intervjua s ispitanicima: osjećaj vlastite vrijednosti i da su potrebni drugim ljudima, otkrivanje vlastitih mogućnosti i snaga, zaboravljanje vlastitih nevolja kroz pomaganje drugima, mogućnost rađenja boljih stvari u životu, osjećaj pripadnosti društvu, osjećaj braniteljskog zajedništva. Ovi rezultati upućuju na potrebu opsežnijeg uključivanja braniteljske populacije u društveni život kroz razne aktivnosti i sadržaje koji nisu sporadični i vezani samo uz rad pojedinih aktivnih braniteljskih udruga. Ključne riječi: hrvatski branitelji, posttraumatski rast, aktivnost branitelja u krizama, potres, pandemija
A formação do mundo atlântico todas as cores do clima da terra
Authors: Petrocchi Renato
Published: December 2022

A proposta do presente artigo é reconstituir narrativamente a formação histórica do mundo atlântico. Para tanto foram combinadas as perspectivas transnacional, transatlântica, nacional e regional do debate atlanticista contemporâneo, com ênfase nas trocas comerciais e nos intercâmbios de ideias, religiões e práticas culturais; nos fluxos migratórios; nas transferências ecológicas e na expansão imperial em escala global. Essa abordagem, debitaria da revisão historiográfica no campo atlanticista, privilegia a análise de uma dada conjuntura oceânica com base em categorias analíticas capazes de abarcar, de modo integrado os espaços terrestres, deslocamentos, fluxos e movimentos próprios do “espaço marítimo”, aqui considerado preferencialmente como o resultado de uma rede diversificada e integrada de várias regiões costeiras do Atlântico, pela ação de múltiplos atores.
La guerra entre Rusia y Ucrania y sus implicancias para la defensa en América del Sur
Authors: Battaglino Jorge
Published: December 2022

El artículo indaga sobre las lecciones que pueden extraerse para la defensa de los países de América del Sur del conflicto entre Rusia y Ucrania. Aunque se trata de un enfrentamiento lejano para la región por su contexto geopolítico, su historia y el tipo y magnitud de alianzas que se enfrentan, algunos aspectos pueden ser considerados para reflexionar sobre la defensa y sobre sus desafíos futuros. El artículo examina seis cuestiones que pueden ser analizadas dado el conocimiento disponible sobre el conflicto. Ellos son: la vigencia de la guerra convencional entre estados, el mito del triunfo de as potencias militares, la importancia de una doctrina nacional de la defensa, el impacto de los medios de comunicación en las guerras, la importancia de la industria de la defensa y de las alianzas y cooperación regionales.
O Direito Internacional e a Defesa Cibernética da soberania na Amazônia Azul
Authors: Teixeira Alexandre , Oliveira Liziane
Published: December 2022

Em 2013, foi editado o primeiro Manual de Tallinn, sobre o Direito Internacional Aplicável às Operações Cibernéticas e aludia apenas às operações cibernéticas em tempo de guerra. O segundo Manual, publicado em 2017, também considerou as operações cibernéticas realizadas em tempo de paz. Tendo em vista a importância da normatização do ciberespaço para a guerra naval, o presente artigo se propõe a analisar as regras sugeridas pelo emergente Direito Internacional Aplicado às Operações Cibernéticas, para atividades que sejam realizadas no contexto das operações navais. Desta forma, a pesquisa emprega o método de revisão bibliográfica, com base em fontes primárias e secundárias, tais como relatório do Grupo de Especialistas Governamentais da ONU (UNGGE), o Manual de Tallinn 2.0 e artigos científicos sobre o tema. Cabe ressaltar que Manual de Tallinn 2.0 promoveu o encontro do emergente Direito Internacional Aplicável às Operações Cibernéticas com a consolidada lei da guerra naval. Esse encontro gera percepções legais que devem ser avaliadas com extrema atenção.
Shimmy analysis of light weight aircraft nose wheel landing gear
Authors: Giridharan V. , Sivakumar S.
Published: December 2022

This paper presents mathematical modeling and analysis of shimmy oscillations for a light weight airplane single wheel nose landing gear. Shimmy is a self-excited oscillation which occurs usually on the nose wheel landing gear assembly during ground maneuvers which is governed by the dynamic characteristics of the landing gear and tires. Shimmy oscillation may lead to reduce the fatigue life of the landing gear and fuselage structure. So, the study of dynamic response and stability boundaries of landing gear plays crucial role while designing of airplanes. In earlier studies of vehicle shimmy only 3 degrees of freedom (DOF) considered such as torsional mode, lateral bending mode and tire lateral deformation. In this work along with above mentioned DOF, two more additional DOF introduced such as axial vibration of strut and tire in order to include the effect of vertical dynamics on shimmy model. Gyroscopic coupling effect also included in the model to study its influence on shimmy. Analysis carried out to determine critical velocity region for occurrence of shimmy and to investigate the effectiveness of ground unevenness on the landing gear system for two different runway conditions such as flat runway and random roughness runway. The results are more helpful to study significant interaction between the different parameters of landing gear and to represent stability boundaries.
TDOA positioning in the presence of atmospheric refraction and observer uncertainty influence analysis and correction
Authors: Wu Yanlin , Zhang Shuqiang , Zhu Wei , Nie Zongzhe
Published: December 2022

Due to the inhomogeneity of the atmosphere, radio waves are subjected to refraction during the propagation process, which reduces its propagation speed and bends the propagation path. If the influence is not considered, a large error will be caused by using time difference of arrival (TDOA). The influence of atmospheric refraction on the TDOA localization under the known elevation constraint is analyzed, a subsection iterative method is proposed to correct the localization error caused by atmospheric refraction, the Cramer-Rao lower bound (CRLB) for location estimation under atmospheric refraction is deduced. The effectiveness of the proposed method is validated through simulation results and analysis.
Influence of construction technology on the retroreflective performance of two-component traffic marking
Authors: Qian Huaxin , Lu Xiaosong , Kou Panpan , He Rui
Published: December 2022

The construction technology of traffic marking has a significant influence on its retroreflective performance. To study the effect of different construction processes on the service performance of traffic markings, two-component spraying paint and two different glass beads were chosen to produce traffic markings that were prepared by single-layer or double-layer spraying, as well as once and twice surface spraying of glass beads. The effects of glass bead coating, spraying times of glass beads and paints on the surface morphology and retroreflective performance of traffic markings were investigated, as well as the variation of the retroreflective coefficient (RC) at the early and middle stages. The results indicated that double-layer spraying was more effective than single spraying. The coated glass beads would decrease the initial RC of the markings, but improved their long-term service performance. The TP-21C has the finest overall retroreflective performance and the lower construction complexity.
Modeling the impact of a family structure on household water consumption
Authors: Wang Mei , Fu Hanliang , Zhou Xinfa , Cheng Zhe
Published: December 2022

Household water consumption plays an important role in addressing the problem of water shortage and achieving sustainable water development. To identify, assess, and analyze the impact of a family structure on household water consumption, this study develops a mathematical statistical method to conduct multi-scenario simulations of average annual household water consumption based on data from the 2016 China Family Panel Studies (CFPS). The Kolmogorov–Smirnov test and the two independent sample t-tests were used to obtain the distribution with the highest degree of fitting, and the probability distribution and expected value of average annual household water consumption were obtained from the distribution probability function. The results demonstrated that the Birnbaum–Saunders distribution was the optimal distribution; families comprising one and two generations were dominant in terms of water consumption; and the number of water-saving households was far less than that of households with high levels of water consumption. The findings of this study have valuable implications for water governance and the domestic water planning.
Quantifying the contribution of uncertainty sources of artificial neural network models using ANOVA for reservoir power generation
Authors: Jiang Wenhang , Liu Jiufu , Peng Anbang , Liu Guodong , Zhang Rong
Published: December 2022

There are many sources of uncertainty in reservoir operation. The presence of these uncertainties might lead to operation risks, which directly affect the comprehensive benefit of reservoirs. This study developed a simple framework to quantify the uncertainty contribution arising from the inputs, model structures, model parameters, and their interaction in the reservoirs. We established a deterministic reservoir operations model with the intention of maximizing power generation, and the scheduling results with the inputs and optimal output datasets were used for data-driven models – artificial neural networks (ANNs). The time period, inflow, storage, and inflow in the last period were chosen as input, integrating with ANN models of different structures and parameters, to produce an ensemble of 10-day forecasts of power generation. The analysis of variance (ANOVA) method was applied to quantify the contribution of the uncertainty sources. The results demonstrated that the inputs were the predominating source of uncertainty in the reservoir operation, especially from May to October. In addition, the uncertainty caused by the interactions between the three sources of uncertainty was more considerable than that of the model structure or parameter in November–April, and the uncertainty contributions of the model structure or parameter were relatively marginal.
Desalination of saline fields by soil leaching in the Karkhehnur Watershed, Iran
Authors: Shariati Behruzi Hamid , Najafi Payam , Chavoshi Elham , Honarjoo Naser
Published: December 2022

Since large parts of agricultural fields are saline or subjected to salinity stress, practical and efficient methods may be used for recycling fields, worldwide. The effects of the type and amount of soil leaching on the quality of saline fields, in different parts of the world have yet to be investigated. The objectives were to investigate: (1) the optimum depth of water required to decrease soil salinity of saline fields to the levels, suitable for crop production in the Karkhehnur Watershed, Khuzestan province, Iran, and (2) the most suitable method of soil surface leaching. Four different regions were selected for the experiment, and a wide range of soil-related parameters as well as water properties was determined. Soil leaching was conducted by surface continuous irrigation (three regions), and surface alternative irrigation (one region). The depths of soil leaching were equal to 0–25, 25–50, 50–75, 75–100, 100–125, and 125–150 cm. The class of salinity was changed to S2 (EC = 24 dS/m) from an initial class of S4 (EC = 87 dS/m) using a water depth of 25–125 cm in different experimental regions. If soil is highly saline, continuous irrigation may be a more effective method, however, under less stressful conditions, alternative irrigation can also be recommendable.
Analysis of the spatial and temporal evolution of water and soil resource carrying capacity in arid region of northwest China
Authors: Xu Cundong , Wang Xin , Liu Zijin , Hu Xiaomeng , Tian Junjiao , Zhao Zhihong , Ren Zihao
Published: December 2022

The spatial and temporal evolution process of the water and soil resource carrying capacity in artificial oases in the arid zone of China was accurately revealed. This study constructs a water and soil resource analysis system based on system dynamics. It integrates cloud theory and hierarchical analysis to analyze the evolutional trend of the water and soil resource carrying capacity in irrigation areas. The spatial analysis technique was used to obtain a raster map of the spatial and temporal characteristics of the influencing factors, and analyze the evolutionary characteristics of the water and soil resources carrying capacity by integrating multi-source data. The results showed that: (1) the evaluation clouds of water and soil resources carrying capacity in 2002, 2010, and 2018 were (0.5034, 0.0236, 0.0071), (0.5586, 00218, 0.0062), and (0.5989, 0.0249, 0.0061), respectively. This showed that the carrying capacity of water and soil resources was transitioning from ‘critical bearing’ to ‘good bearing’, but the evolution rate was gradually decreasing; (2) from 2002 to 2018, the size of the ‘good bearing’ area increased by 8.38%, while the size of the ‘severe bearing’ area decreased by 6.4%; (3) the degree of dramatic evolution of the carrying capacity of water and soil resources is: continuous change > pre-change > post-change > continuous stable > repeated change; (4) the serious carrying capacity area shows a spatial pattern of decreasing in an arc from the town to the surrounding areas. The results showed that water and soil resource-carrying capacity of the irrigation area shows a healthy and continuous spatial and temporal evolution trend.
Optimal allocation of irrigation water in a single-reservoir and a single-pumping-station system under deficit irrigation conditions
Authors: Wei Cong , Cheng Jilin
Published: December 2022

Aiming at the optimal allocation of irrigation water in a multi-water source project in a water resource shortage area, this study developed a water resource joint scheduling optimization model for the reservoir and the pumping station under deficit irrigation conditions. In the model, the maximum annual yield of the irrigation area was the objective function; the water supply, water spill of the reservoir and replenishment water of the pump station at each stage were the decision variables; and the total annual water supply of the system, the reservoir operation criteria, the water rights of the pumping station, and the water demand of the crop during the entire growth period were the constraint conditions. According to the characteristics of the model, a large system decomposition aggregation dynamic programming (DADP) method is proposed to transform the N + 1 dimensional dynamic programming problem into a N + 1 one-dimensional dynamic programming problem for solution. In addition, this study also uses the real-coded genetic algorithm (RGA) and DADP to compare the algorithms, and discusses the performance of the two algorithms from the optimization of the algorithm and the applicability of the algorithm.
Bioaugmentation enhance the bioremediation of marine crude oil pollution: Microbial communities and metabolic pathways
Authors: Gao Yu , Cai Mengmeng , Shi Ke , Sun Rui , Liu Suxiang , Li Qintong , Wang Xiaoyan , Hua Wenxin , Qiao Yanlu , Xue Jianliang , Xiao Xinfeng
Published: December 2022

Bioaugmentation is an effective strategy used to speed up the bioremediation of marine oil spills. In the present study, a highly efficient petroleum degrading bacterium (Pseudomonas aeruginosa ZS1) was applied to the bioremediation of simulated crude oil pollution in different sampling sites in the South China Sea. The metabolic pathways of ZS1 to degrade crude oil, the temporal dynamics of the microbial community response to crude oil contamination, and the biofortification process were investigated. The results showed that the abundance and diversity of the microbial community decreased sharply after the occurrence of crude oil contamination. The best degradation rate of crude oil, which was achieved in the samples from the sampling site N3 after the addition of ZS1 bacteria, was 50.94% at 50 days. C13 alkanes were totally oxidized by ZS1 in the 50 days. The degradation rate of solid n-alkanes (C18–C20) was about 70%. Based on the whole genome sequencing and the metabolites analysis of ZS1, we found that ZS1 degraded n-alkanes through the terminal oxidation pathway and aromatic compounds through the catechol pathway. This study provides data support for further research on biodegradation pathways of crude oil and contributes to the subsequent development of more reasonable bioremediation strategies.
Efecto de los finos no plásticos en la respuesta no drenada de una arena de relaves a altas presiones
Authors:   Universidad de Chile, Santiago, Chile, Silva-Contreras Diego , Ochoa-Cornejo Felipe ,   Universidad de Chile, Santiago, Chile
Published: December 2022

Los tranques de relave tienen un rol crítico en la operación minera, y hoy en Chile alcanzan alturas de hasta 250 m, induciendo esfuerzos por sobre los encontrados en la práctica estándar en ingeniería geotécnica. Incluyendo el constante riesgo de licuefacción en un país sísmico, entender el comportamiento de las arenas de relaves es vital para lograr diseños mejores y más seguros. Este trabajo presenta el análisis de 56 ensayos triaxiales no drenados para estudiar el efecto del contenido de finos y el nivel de confinamiento en la respuesta monótona no drenada de una arena de relaves. Probetas de arena remoldeadas con 1% y 20% de finos fueron ensayadas con confinamientos entre 0.2 y 5 MPa. Los resultados sugieren que la variación del contenido de finos tiene un efecto significativo en la resistencia no drenada y el estado último, y bajo efecto en el ángulo de fricción y módulo de deformación. A la vez, altos esfuerzos disminuyen el ángulo de fricción curvando la envolvente de falla, reducen la dilatancia e inducen abrasión en las partículas. Los resultados son comparados con aquellos obtenidos en ensayos drenados y de compresión.
Coeficiente de empuje en reposo – Jáky 1944
Authors:   Universidad Católica de Valparaíso, Valparaíso, Chile., Diaz-Segura Edgar Giovanny
Published: December 2022

El artículo originalmente titulado “A nyugalmi nyomás tényezője” (Coeficiente de empuje en reposo) del Dr. József Jáky publicado en 1944, se encuentra dentro de los más citados en ingeniería geotécnica, y su hipótesis aún sigue vigente. Sin embargo, el haberse publicado originalmente en húngaro, en parte ha dificultado el conocimiento de la formulación completa de su teoría, lo que ha conllevado a que una cantidad importante de autores se ciñan solo a referenciar una versión simplificada de la ecuación para la determinación del coeficiente de empuje en reposo, k0, sin hacer alusión a su origen, desconociendo en algunos casos que la ecuación propuesta es de tipo analítico y no empírico, y que es aplicable a materiales granulares de cualquier tipo, incluyendo cereales. El presente documento aporta una versión rigurosa del artículo original del Dr. Jáky, lo cual permite conocer las formulaciones, así como los límites de validez, que hay detrás de la determinación de k0 usando la ampliamente conocida teoría de Jáky.
Effect of Aging on Deferasirox Therapy in Transfusion-dependent Patients. A Prospective-
Retrospective, Cohort-study
Authors: Marini Valeria , Pinto Valeria Maria , Stella Manuela , Fucile Carmen , Lantieri Francesca , Luci Giacomo , Gianesin Barbara , Bacigalupo Lorenzo , Forni Gian Luca , Mattioli Francesca
Published: December 2022

Background:

Iron-chelation therapy is life-saving in patients on a chronic transfusion regimen as it reduces organ damage related to iron deposition in the tissues. Deferasirox, an iron-chelator, is characterized by pharmacokinetics variability, and some patients may discontinue the treatment due to toxicities.

Objective:

Understanding whether deferasirox plasma levels are related to patients' specific characteristics could help optimize DFX dosage.

Methods:

We analyzed deferasirox plasma concentration in 57 transfusion-dependent anemic patients using the HPLC method in this prospective-retrospective cohort study. All outpatients (3 to 98 years) were treated with deferasirox (film-coated tablet) for at least one year (median dose, 16.5 mg/Kg once a day). Deferasirox plasma concentration was normalized for dose/Kg (C/dose) and corrected with a linear regression model that relates C/dose and the time of blood sampling (Cref/dose).

Results:

No significant differences in Cref/dose were found between males and females, either between different types of hemoglobinopathies or depending on the presence of the UGT1A1*28 polymorphism. Cref/dose has a positive and significant correlation with age, creatinine, and direct bilirubin. Cref/dose, instead, has a negative and significant correlation with Liver Iron Concentration (LIC), ferritin, and eGFR. Cref/dose was significantly different between three age categories <18yrs, 18-50yrs, and >50yrs, with Cref/dose median values of 1.0, 1.2, and 1.5, respectively.

Conclusion:

The study evidenced that to ensure the efficacy of deferasirox in terms of control over LIC and, at the same time, a lesser influence on renal function, the dose of the drug to be administered to an elderly patient could be reduced.
The Role of Genetics and Synergistic Effect of Targeting Common Genetic
Mutations in Acute Lymphoblastic Leukemia (ALL)
Authors: Pilehvari Niloofar , Katoueezadeh Maryam , Hassanshahi Gholamhossein , Torabizadeh Seyedeh Atekeh , Torabizadeh Seyed Mohammad
Published: December 2022

Increasing concern regarding non-treatment and relapse in Acute Lymphoblastic Leukemia
(ALL) among children and adults has attracted the attention of researchers to investigate
the genetic factors of ALL and discover new treatments with a better prognosis. Nevertheless, the
survival rate in children is more than in adults; therefore, it is necessary to find new potential molecular
targets with better therapeutic results. Genomic analysis has enabled the detection of different
genetic defects that are serious for driving leukemogenesis. The study of genetic translocation
provides a better understanding of the function of genes involved in disease progression. This
paper presents an overview of the main genetic translocations and dysregulations in the signaling
pathways of ALL. We also report the inhibitors of these main translocations and evaluate the synergistic
effect of chemical inhibitors and gamma-ray irradiation on ALL.
Role of the Clinical Data Managers During the COVID-19 Pandemic: An
Overview
Authors: Sajja Rishitha
Published: December 2022

Background:

The COVID-19 pandemic has significantly changed the implementation of clinical trials. A large focus has been directed on clinical trial design, timeline, and best practices. It has led clinical trial study teams to update the existing processes and perform a risk assessment to mitigate the impact of the COVID-19 pandemic according to ICH-GCP (Good Clinical Practice) requirements. Data management plays a crucial role in understanding the study team's needs and developing innovative solutions. The Clinical Data Manager (CDM) is a core clinical trial Study Team member, responsible for promptly collecting, managing, and delivering complete, high-quality data.

Objective:

The COVID-19 pandemic required the Clinical Data Manager(CDM) to respond to changing needs by adapting data collection tools, data review strategies, and data management processes to answer new questions and address new challenges. CDMs became responsible for identifying how the COVID-19 pandemic impacted current data management processes and documentation and implementing changes to reflect new ways of working. The present article reviews the impact of the COVID-19 pandemic on clinical trials and the solutions adopted by the Clinical Data manager.

Conclusion:

The collection of COVID-19-related data points provides a better understanding of patient safety during the pandemic and proactively fulfills the growing regulatory interests. Strategies and innovative solutions adopted by the Clinical Data Manager serve as guidance for the clinical research team during the crisis to make the trials more robust and patient-centered.
Heat Stress Nephropathy: What Have We Learned?
Authors: Singh Gurfateh , Jaswal Priya , Basu Jhilli , Kaur Devinder
Published: December 2022

The unbearable heat waves that we are experiencing these days around the world are the
result of increasing global warming, leading to heat stress and a constant health issue for the existing
population. The thermoregulatory dysfunction of the human body due to climatological changes might
result in fluid and electrolyte imbalance and transforms the human body from a normal physiological
condition to a distorted pathological state. Subsequently, at one point in time, the human body may fail
to handle its normal thermoregulatory function in the form of sudden unconsciousness and health defects.
There might be associated dehydration that imposes renal damage, even to the extent to cause
acute kidney injury (AKI), followed by chronic kidney disease (CKD). Thus, we cannot deny CKD as
a major cause of death, mainly in patients having long-standing medical issues such as cardiac dysfunction,
hypertension, diabetes, and obesity, heat stress nephropathy (HSN) might therefore become
a major health problem. There is always a hopeful way in our hands, fortunately, which is of course
prevention, that comes through government policies and human awareness. The present review brings
out light on the alarming resultant facts of heat stress, dehydration, its pathology, molecular derangements,
and recommendations for the prevention of heat stress nephropathy.
Anesthesia for Cesarean Section
Authors: Juan Álvarez Mónica San , Vinasco Adriana Orozco , Castillo Marta Chacón , Correa Barrera Juan José
Published: December 2022

Caesarean section is the most frequently performed surgery in adults, with a
total of 20 million procedures per year. More than 70% of cases are due to lack of labor
progression, fetal distress, breech presentation or previous cesarean section.
Obstetric anesthesia practice has substantially changed over the last 20 years. The main
cause of this is the introduction of regional techniques to the detriment of general
anesthesia, which has reduced maternal mortality due to complications such as gastric
aspiration or difficulty in orotracheal intubation. In general, we can affirm that regional
anesthesia is the most frequently used anesthetic technique for cesarean section,
reserving general anesthesia for urgent or life-threatening situations.
Anesthetic Management of the Pregnant Patient with Comorbidities
Authors: Carreño Anna Pascual , Moya Aleix Clusella , Albiol Mireia Pozo , Blazquez Gomez Eva Maria , Martin Mateos Esperanza
Published: December 2022

An increase in pregnant patients with comorbidities has been seen in the last
decade. Nevertheless, these patients are able to enjoy longer and better quality lives
nowadays. During pregnancy, patients can experience decompensations of their chronic
disease which can be sometimes challenging for the medical team. Complexity has
risen; that is why the anesthesiologist must be updated and capable of facing different
scenarios both in the delivery room and before or after birth.
This chapter offers a practical and synthetical approach to the most common situations
in which a general anesthesiologist can be involved, aiming to emphasize main points
for safe and accurate anesthetic care.
Anesthetic Management of Pregnant Patients with Infectious Disease
Authors: Alonso Vila Serafín , Suárez Edo Elena , Sánchez Royo Elena , Marieges Anna Conesa , Manrique Muñoz Susana
Published: December 2022

Fever is often the result of an infection. The most common sites for infection
during pregnancy are fetal membranes, urinary and respiratory tracts, and the
postpartum uterine cavity. The most frequent etiologies of intrapartum fever are
chorioamnionitis and neuraxial anesthesia. Maternal and fetal exposure to hyperthermia
and inflammation is associated with adverse consequences for the mother and the
neonate. In pregnant women with fever, anesthesiologists are not only involved in
providing analgesia, but also in the correct anesthetic management for the surgical
treatment of the infectious region. Thus, as pyrexia may change both obstetric and
anesthetic management, preventing maternal fever is imperative. Emerging and
challenging infectious diseases, as COVID-19, remind us of the susceptible nature of
pregnant and early postpartum women to severe respiratory infections, reinforcing the
importance of vaccines and therapeutic measures during pregnancy.
Applications of Ion Exchange Resins in Water Softening
Authors: Dzyazko Y.
Published: December 2022

Surface and groundwater always contain hardness ions (Ca2+ and Mg2+). The hardness is an important characteristic that provides the consumer properties of water. This parameter must be taken into consideration by the stations of water treatment, thermal power plants, the enterprises of chemical, food, pharmaceutical industries. Ion exchange resins, which are intended for water softening, are considered in this chapter. The negative effect of hardness ions on human health and equipment is also a focus of attention. Special approaches for increasing the efficiency of water softening are also reported. These approaches involve combining ion exchange with electrodialysis or ultrasound.
MEASURING APPLICATION AUGMENTED REALITY TO INCREASE MSME PERFORMANCE USING TECHNOLOGY ACCEPTANCE MODEL
Authors:   Management, Universitas PGRI Semarang, Indonesia, Setyorini Noni , Violinda Qristin ,   Management, Universitas PGRI Semarang, Indonesia, Ulumudin Arisul ,   Study Program of Primary School Teacher, Universitas PGRI Semarang, Indonesia, Wattegama Erandi Jinadari ,   Banking and Finance, Wayamba University of Srilanka, Srilanka
Published: December 2022

This study aimed to examine the effect of perceived usefulness and perceived ease to use on the performance of MSMEs in Ngerangan Village, Klaten, with trust as a mediator. The data collection method used is probability sampling with a saturated sampling technique. The total respondents in the study were 100 respondents, which is MSME in Ngerangan Village. Hypothesis testing using smartPLS software. The study results are perceived usefulness and perceived ease of use affect trust. Likewise, trust influences the performance of MSMEs in Ngerangan Village. However, perceived usefulness does not directly affect the performance of MSMEs. In contrast to perceived ease to use, which directly influences the performance of MSMEs. The practical implications of this research are that the technology adopted by MSMEs must be easy to use and have many benefits for business development.
PERSONAL SELLING AND DIGITAL MARKETING AS CRUCIAL FACTORS IN MAXIMIZING CUSTOMER SATISFACTION THROUGH PERCEIVED VALUE IN THE USAGE OF M-BANKING APPLICATION
Authors:   Faculty of Economics and Business, Universitas, Indonesia, Sembhodo Abimanyu Tuwuh , Hermawati Adya ,   Universitas Widyagama Malang, Indonesia, Fatmawati Endang ,   Universitas Diponegoro, Semarang, Indonesia, Junaedi I Wayan Ruspendi ,   Universitas Dhyana Pura, Indonesia, Ali Shujahat ,   Mirpur University of Science and Technology, Pakistan
Published: December 2022

The use of mobile banking applications supports the level of customer satisfaction of BPR Lembah Artha. The growth in the use of mobile banking shows customer satisfaction and the success of digital marketing. The research aims to find out that the relationship between personal selling and digital marketing can increase perceived value, personal selling relationships, digital marketing, and the perceived value of users of mbanking applications users. Perceived value can mediate personal selling on customer satisfaction, and perceived value can mediate digital marketing on satisfied customers. The quantitative approach is used as a research approach. Data were collected by questionnaire. The data collected were analyzed to determine the effect between variables, and the analysis technique was Partial Least Square (PLS). The research was conducted at BPR Lembah Artha. The research subjects are BPR Lembah Artha customers who use the Mobile Banking application. The object of research is a review of the effect of personal selling and digital marketing on customer satisfaction by mediating value perceptions. The sampling technique is purposive sampling. The results show that personal selling and digital marketing affect perceived value; personal selling, digital marketing, and perceived value affect satisfaction. Perceived value can mediate the effect of personal selling on customer satisfaction/users of the m-banking application. Perceived value can mediate the effect of digital marketing on customer satisfaction/users of the m-banking application. Better personal selling and digital marketing can improve customer perceptions of value. Good value perception is indicated by customer satisfaction and supports personal selling.
ROLE OF KNOWLEDGE SHARING AND LEADERSHIP STYLE IN IMPROVING EMPLOYEE PERFORMANCE WITH WORK CULTURE AS AN INTERVENING VARIABLE
Authors:   Universitas Muhammadiyah Jember, Indonesia, Sanosra Abadi , Hakim Arief Rahman ,   Universitas Muhammadiyah Jember, Indonesia, Cahyono Dwi ,   Universitas Muhammadiyah Jember, Indonesia, Qomariah Nurul ,   Universitas Muhammadiyah Jember, Indonesia, Thamrin Muhammad ,   Universitas Muhammadiyah Jember, Indonesia
Published: December 2022

Competition in the cement industry is increasing with the opening of opportunities for foreign cement industries to take part in the country. This paper aims to re-examine the effect of sharing and leadership skills on work culture. The next research aims to know the effect of knowledge sharing and leadership style on employee performance. This research was conducted at PT. Semen Bosowa, which is located in Banyuwangi Regency. The number of employees owned by PT. Semen Bosowa, located in Banyuwangi, has 94 employees, all used as research samples (saturated samples). Descriptive analysis is used to describe respondents and variables in the study. The study used test tools to test the validity of research data and the reliability of research data to measure the questionnaire. PLS (Partial Least Square) analysis with the Smart PLS version 3 application was used to test the research hypotheses of 5 (five) direct hypotheses and two indirect hypotheses. The research results after the analysis is that knowledge sharing in PT. Semen Bosowa has no impact on the work culture of the employees. The leadership style in the organization has a positive impact on the work culture in the PT. Bosowa Banyuwangi. Knowledge sharing of employees of PT. Semen Bosowa turned out to be able to improve employee performance. The leadership style that exists at PT. Bosowa Banyuwangi has a positive and significant effect on employee performance. The next result is the work culture of the employees of PT. Bosowa Banyuwangi has no effect on employee performance.
THE INFLUENCE OF GRIT TOWARDS WORK ENGAGEMENT AND THE MODERATING ROLE OF PERCEIVED ORGANIZATIONAL SUPPORT
Authors:   Prambanan Regional Public Hospital, Sleman Government, Indonesia, Yudiarti Andina , Putranta M. Parnawa ,   Universitas Atma Jaya Yogyakarta, Indonesia
Published: December 2022

Grit has been found before as a non-cognitive predictor beyond talent and intelligence, which drives a person to exert the best potential. This study investigates the influence of grit on work engagement, which contains perseverance of effort and consistency of interest. It also investigated the role of perceived organizational support in moderating this influence. The research analysis unit comprised 252 health workers and Medical Laboratory Technicians, with a minimum working period of three years, who were active as employees working in medical laboratories in various institutions, the Special Region of Yogyakarta and Central Java. Data is processed using SEM-PLS with SmartPLS 3.2 software. The study’s results revealed a positive influence on the perseverance of efforts, the consistency of interest, and perceived organizational support on work engagement. In its role as moderating, perceived organizational support is found to weaken the influence of perseverance of effort on work engagement and strengthen the influence of consistency of interest on work engagement. These findings are expected to provide direction for organizations to increase support for employee self-development.
Celebrating John Rawls: 100 years since his birth; 50 years after the publication of a theory of justice. Introduction: On celebrating Rawls
Authors: Rosas João Cardoso , Baptista António
Published: December 2022

Celebrating John Rawls: 100 years since his birth; 50 years after the publication of a theory of justiceIntroduction: on celebrating Rawls
Исследование фокусирующих свойств концентратора фотоэлектрического модуля в расширенном температурном диапазоне
Authors: Ионова Е.А. , Давидюк Н.Ю.
Published: December 2022

Abstract: In the current work properties of a solar radiance concentrator with Fresnel lens made of Elastosil RT604 silicon made by Wacker have been investigated. The dependence of concentrator focal distance on temperature has been determined. Impact of variation of temperature-dependent concentrator focusing properties on the magnitude of short current of photovoltaic submodule has been determined by direct measurements using solar simulator. Using formalized model of modules based on the studied concentrator and solar cells with three and six p-n junctions dimensions of a solar image in a wavelength range corresponding to an absorption profile of individual p-n junctions has been calculated for the temperature range 10-60 C. It has been concluded that in the case of three p-n junctions the minimum size of solar image at focal plane was 4.7 mm with the distance between the concentrator and solar cell being equal to 106.25 mm, and in the case of six p-n junctions, the minimum size was 4.8 mm with the distance between concentrator and solar cell being equal to 106.5 mm.
Gender Equality Training for Students in Higher Education: Protocol for a Scoping Review (Preprint)
Authors: Condron Claire , Power Mide , Mathew Midhun , Lucey Siobhan M
Published: December 2022

BACKGROUND

The principles of gender equality are integral to the goals, targets, and indicators of all sustainable development goals. Higher education institutes can be powerful agents for promoting gender equality, diversity, and inclusion not only in the higher education context but also in society as a whole. To address and overcome gender inequality in the higher education environment, experts posit that change needs to occur from day 1 of the student’s academic experience. To this end, training is required. A preliminary review of the literature indicates that multiple gender equality–based training programs or initiatives for students have been designed and evaluated in second and third-level education settings. Examples of educational activities undertaken include delivery of didactic teaching, participation in a face-to-face collaboration project, site visits, case studies, and coaching. Yet, our initial search indicated that, to date, a comprehensive review collating the available evidence on gender equality training for third-level students has not yet been carried out.

OBJECTIVE

Our review seeks to identify and explore the existing literature on gender equality training interventions for third-level students, with a particular emphasis on training content, methodology, and outcome evaluation.

METHODS

This scoping review will be structured using the Arskey and O’Malley’s 5-stage framework and will consider empirical research and other relevant published works that address gender equality training. Systematic searches will be carried out in 6 research databases and the gray literature using key search terms. Inclusion and exclusion criteria have been defined, and a data charting tool created to methodically extract information from selected literature. The free web software Rayyan will be used for primary screening where each reference will be screened in duplicate first by title, then abstract, and finally by full text.

RESULTS

This review forms part of the LIBRA (Balance) study and has received peer-reviewed grant funding from the Irish Higher Education Authority. LIBRA aims to use simulation-based education to develop a gender equality leadership training program for student leaders in higher education. The findings will be summarized in tabular form, and a narrative synthesis produced to inform curriculum development.

CONCLUSIONS

This review seeks to inform curriculum design by reporting on the gender equality–enabling skills and leadership skills necessary to foster gender equality. This paper should inform recommendations for training and catalyze future research in this rapidly evolving area.

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DERR1-10.2196/44584