bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the primary production and maximum fish production in Salman Farsi Reservoir, Fars Province, Iran
Authors: M. Zamanpoore , F. Sedaghat , M.R Sorbie , N. Ashjar
Published: December 2024

Primary production in water bodies corresponds to their fish production capacity. Aquaculture
planning for water resources is conducted based on specific geographical conditions and their
internal and external factors. Understanding the fish production capacity of lakes enables
predictions for exploitation (fishing) and restoration of reserves. This research aims to estimate
the primary production of the Salman Farsi Reservoir, Fars Province, on the Ghare Aghaj River,
to evaluate fish production capacity and plan aquaculture development. Sampling was conducted
to measure dissolved oxygen, water temperature, pH, conductivity, transparency, total
phosphorus, total nitrogen, and chlorophyll-a in three transversal sections along the side, surface,
and deep areas of the open water, with three repetitions in four seasons during 2023 – 2024.
Trophic conditions were estimated using Trophic Status Index (TSI) models. Total production of
the lake was calculated using the Brämick-Lemke and Koeschel models, while fish production
was calculated using the Brämick-Lemke and Downing models. The annual average of dissolved
oxygen, transparency, electrical conductivity, pH, total phosphorus, total nitrogen, and
chlorophyll-a concentration in the lake was 8.2 ppm, 4.1 meters, 1387 μS/cm, 8.3, 0.174 ppm,
4.50 ppm, and 1.38 ppm, respectively. The average TSI based on transparency, phosphorus,
chlorophyll-a, and Carlson’s index was 40, 78, 33, and 50. The initial production size in the lake
was estimated 292 gC.m-²y-1. Fish production capacity was calculated based on primary
production at 39 Kg.ha-1.y-1 and based on phosphorus at 33 Kg.ha-1.y-1, with an average of 36
Kg.ha-1.y-1. Considering the 2000-hectare livable area for fish in the lake, the total fish
production this year was estimated at 71.8 tons. Under current lake conditions, the allowable
fishing size was estimated to be 7 to 11 tons of fish per year. Determining the production capacity
and trophic level can help maximize exploitation while minimizing ecological impacts and
potential risks associated with restocking and fishing, such as the introduction of excessive
juvenile fish into the lake.
Advanced nanoparticle-based treatment of aquafarm and hatchery effluents: The role of chitosan and chitosan TPP in water purification
Authors: B. Vinusha , N. Gandhi , G Vidya Sagar Reddy , Ch. Vijaya
Published: December 2024

A healthy economy and the multifaceted growth of society depend on access to clean, safe water.
Rapid population growth, growing industrialization, urbanization, and widespread agricultural
activities have led to the production of wastewater that has made the water not only contaminated
or lethal, but also dirty or polluted. Every year, millions of people pass away from diseases spread
by drinking water tainted with harmful microorganisms. Although many different approaches to
wastewater treatment have been researched over the past few decades, their application is
constrained by a number of factors, such as the need for chemicals, the production of disinfection
by-products (DBPs), the length of the process, and the cost. In order to create new structures,
devices, and systems with superior electronic, optical, magnetic, conductive, and mechanical
properties, nanotechnology, which involves manipulating matter at the molecular or atomic level, is
becoming more and more popular. This promising technology has accomplished amazing feats in a
number of industries, including wastewater treatment. Nanomaterials are well suited for use in
wastewater treatment because of their high surface to volume ratio, high sensitivity and reactivity,
high adsorption capacity, and simplicity of functionalization. The methods being explored for
wastewater treatment utilizing nanotechnology have been discussed in this article and are based on
adsorption and biosorption, nano-filtration, photocatalysis, disinfection, and sensor technologies.
The fate of the nanoparticles in wastewater treatment and the dangers of their use are also
highlighted in this review. The present study carried by Evaluation of various physico-chemical
parameters of shrimp farm and hatchery effluents such as alkalinity, electrical conductivity, total
hardness, total suspended solids, total ammonia, BOD, COD, was done before and after treatments
in laboratory scale. From the results of the present investigations chitosan and chitosan TPP
nanoparticles showed good coagulating properties, and has many advantages compared to chemical
coagulants and does not affect the pH, alkalinity or conductivity of the water. Further
multifunctional environmentally friendly chitosan should play a larger role in the recycling of
aquaculture wastewater.
Tarjeta de Observación Preventiva, ¿Primer paso hacia la Seguridad Basada en Comportamiento?
Authors: Pinto Aguilar Luis Andres
Published: December 2024

OBJETIVO: realizar un análisis exhaustivo de la bibliografía existente y una evaluación crítica de la literatura sobre la adopción de un Programa de Gestión de Seguridad Basada en el Comportamiento. MÉTODO: se lleva a cabo una revisión bibliográfica de estudios y artículos relevantes que abordan los beneficios y la implementación de este enfoque en el ambiente organizacional. RESULTADOS: se resalta que la Seguridad Basada en el Comportamiento trasciende tanto factores cualitativos como cuantitativos, permitiendo la prevención de accidentes laborales y concientizando a los trabajadores sobre prácticas seguras. La implementación de la Tarjeta de Observación Preventiva se identifica como un paso crucial para desarrollar una cultura de seguridad proactiva y lograr una interdependencia en seguridad y salud ocupacional. CONCLUSIÓN: el enfoque de Seguridad Basada en el Comportamiento, apoyado por herramientas como la Tarjeta de Observación Preventiva, es efectivo para promover la seguridad y la prevención de accidentes en las organizaciones, fomentando un cambio cultural y conductual entre sus miembros.
Quintessential Delineations of Learning Spaces in English Prose Fiction
Authors: Zıdane Rahmouna
Published: December 2024

The mapping of places in literary texts enables the writer to present the social contexts wherein the characters’ actions and conversations take place; the delineated imaginary spaces may denote domestic spots, country-side landscapes, urban areas or work places depending on the writers’ intentions and the nature of the narrated events. In various novels, the author’s narrative description may depict educational scenes whenever the fictitious personalities are affiliated to educational spheres. Accordingly, literary spaces may take the form of fictional classrooms to reflect the pedagogical concerns of a particular community and enlighten the readers about the epistemic perspectives related to certain academic realms. Consequently, the present article aims at exploring the artistic visualisation of learning environments via the description of instructional sceneries within literary prose. In order to denote miscellaneous illustrations of fictitious classrooms involving different educational contexts, the quoted passages are extracted from a variety of literary works including adult fiction, children’s novels and young adult fiction. The study of the furnished excerpts relies on the use of various techniques of analysis targeting aspects of style and discourse as well as the characters’ speech styles. This manuscript initially presents the significance of the distinct dimensions of educational atmospheres as well as a succinct account of the emergence and development of classrooms throughout history. Subsequently, it furnishes a historical sketch of the reflections of educational settings in fictional works. Then, different facets of literary learning spaces are illustrated through the provision of various examples elicited from several novels to reveal how fictional classrooms can represent images of actual or prospective educational climates. Indeed, this research work attempts to convey the idea that the delineation of learning spaces in narratives constitutes a sort of an aesthetic mapmaking of a set of instances simulating real-life situations.
Investigating Social Media Marketing Adoption among Homestay Operators in Malaysia
Authors: Mohamad Noraihan , Wei Shi Cheng , Azmin Adlina Syahirah
Published: December 2024

The widespread use of social media has revolutionized communication, connectivity quality, and information consumption, making it an indispensable element in human daily lives. As such, social media marketing has emerged as a crucial tool for businesses to promote their products and services. In the case of Small Medium Enterprises (SMEs) in Malaysia, however, found that the adoption of social media marketing remains low, particularly among homestay operators. This study aimed to investigate the factors that influence homestay operators in Malaysia to adopt social media as a marketing medium. By employing a cross-sectional research design, a self-administered questionnaire was used to collect responses from a total of 208 homestay operators in Selangor, Negeri Sembilan, Melaka, and Johor. The results generated by the Structural Equation Modeling revealed that customer pressure and preference, as well as competitive pressure, have a significant impact on social media marketing adoption compared to perceived cost and digital skills. Significantly, this study provides valuable insights to the authorities to understand more about social media marketing adoption among homestay operators in Malaysia so that effective strategies can be highlighted to encourage SMEs in Malaysia to fully utilize new technology for business purposes. Overall, SMEs need to employ new technologies, specifically social media marketing for business growth as it provides extensive and effective connectivity at low cost.
The Determinants of Oromia police crime prevention in selected zones of the Oromia Regional state
Authors:   Oromia Police College, Melak Frezer Yizez , Legese Yerosan Guta ,   Oromia Police College
Published: December 2024

ThestudyaimedtoexplorethefactorsinfluencingOromiapolicecrimepreventioninspecific zones of the Oromia regional state. It hypothesized that police logistics, motivation, perception, corruption, and training and development significantly impact crime prevention performance. The research used a quantitative approach and an explanatory design by collecting primary data from selected zones of the Oromia regional state through survey questionnaires.388questionnairesweredistributedtorespondents,and372 were completed. The data was analyzed using mean and standard deviation, and the dependent variable was projected using multi linear regression beta coefficients for all independent variables. The study reveals that most respondents in the selected zones of Oromia regional state police disagree with the current police logistics, stating they lack infrastructure, necessary equipment, and technology for effective crime prevention. They also believe basic human needs like home, food, uniforms, and a salary are insufficient. Public cooperation, perceptions of the police, and commitment to crime prevention are moderate, while police corruption and training practices are moderate. The study suggests that if these factors continue, crimeprevention performance could be hazardous and potentiallyincrease societal compliance toward safety and good governance. The government should raise financing for police equipment, develop motivational strategies, improve loyalty, and establish anti-corruption organizations. Off-the-job training for crime prevention heads should be provided twice a year.
Keywords: crime prevention, corruption, motivation, perception, police logistics, training, and development
Olie og pilekviste
Authors: Engel Uggi
Published: December 2024

Intet resumé
Fribrødre Å: Geologi i vikingetid
Authors: Jakobsen Erik Maagaard
Published: December 2024

Intet resumé
Bornholms fjeld
Authors: Berthelsen Asger
Published: December 2024

Intet resumé
Rhodos - hvad nogle bryozoer ku’ fortælle
Authors: Håkansson Eckart , Madsen Lena
Published: December 2024

Intet resumé
Bornholms Mesozoikum
Authors: Hamann Niels Erik
Published: December 2024

Intet resumé
Dansk Polarcenter
Authors: Secher Karsten
Published: December 2024

Intet resumé
Landet omkring molerhavet
Authors: Pedersen Stig Asbjørn Schack
Published: December 2024

Intet resumé
Samme lag - forskellig alder?
Authors: Håkansson Eckart , Christensen Walter Kegel
Published: December 2024

Intet resumé
Santorini - en aktiv vulkan i Middelhavet
Authors: Håkansson Eckart , Jensen Erik Schou
Published: December 2024

Intet resumé
Naturlige superellipsoider
Authors: Skjernaa Lilian
Published: December 2024

Intet resumé
Flint-fisk, moler-fiske, tropefisk og danekræ
Authors: Bonde Niels
Published: December 2024

Intet resumé
Geologisk kort over den danske undergrund
Authors: Håkansson Eckart , Pedersen Stig Asbjørn Schack
Published: December 2024

Intet resumé
På sporet af gammel kulde og varme
Authors: Skibsted Søren
Published: December 2024

Intet resumé
Landslide
Authors: Pedersen Stig Schack
Published: December 2024

Intet resumé
Er vættelhys lys? En anmeldelse
Authors: Håkansson Eckart
Published: December 2024

Intet resumé
Der er rav i genskabte dinosaurer ‘Cretaceous Park’
Authors: Bonde Niels
Published: December 2024

Intet resumé
Dansk Lithosfærecenter
Authors: Marker Mogens
Published: December 2024

Intet resumé
Røgkvarts – årstidens mineral
Authors: Jensen Aage
Published: December 2024

Intet resumé
Danekræ – fisk, store og små og ´'gravede'
Authors: Bonde Niels
Published: December 2024

Intet resumé
Conodonter – geologiske termometre
Authors: Stouge Svend Stouge , Rasmussen Jan Audun
Published: December 2024

Intet resumé
Boganmeldelse. Dougal Dixon: Feltgeologi. Høst og Søns Forlag 1993, 159 sider
Authors: Graversen Ole
Published: December 2024

Intet resumé
Jordskælv, plader der forskydes og forsvinder
Authors: Berthelsen Asger
Published: December 2024

Intet resumé
Tidligt tertiære fisk - flere danekræ
Authors: Bonde Niels
Published: December 2024

Intet resumé
Pegmatiter
Authors: Maaløe Sven
Published: December 2024

Intet resumé
Mineraler opkaldt efter danskere I
Authors: Rose-Hansen John
Published: December 2024

Intet resumé
Fusion i geologiverden
Authors: Binzer Knud
Published: December 2024

Intet resumé
Hovgårdsryggen i Framstredet – et arkto-tertiært floristisk ’Atlantis’
Authors: Manum Svein B.
Published: December 2024

Intet resumé
Minturn cirkler – et mystisk naturfænomen
Authors: Appel Peter
Published: December 2024

Intet resumé
Kryolitforekomsten i Ivittuut (Ivigtut) - opbygning og dannelse
Authors: Bailey John
Published: December 2024

Intet resumé
Pegmatitstrukturer fra Sydnorge
Authors: Fougt Henrik
Published: December 2024

Intet resumé
Kimbeflitter i Grønland
Authors: Steenfelt Agnete
Published: December 2024

Intet resumé
Burgess skiferen - mærkværdigheder fra ‘Den kambrise Eksplosion’
Authors: Lindow Bent , Nielsen Simon
Published: December 2024

Intet resumé
Forklaringer på ‘forklaring søges’
Authors: Redaktionen
Published: December 2024

Intet resumé
Boganmeldelse. Palle Vibe: Jordskælv: Hvad skete der? Gyldendalske Boghandel, Nordisk Forlag A/S, København 1998, 72 sider
Authors: Berthelsen Asger
Published: December 2024

Intet resumé
En norsk? flintesten fra den danske askeserie
Authors: Heilmann-Clausen Claus
Published: December 2024

Intet resumé
Renderne i Storebælt - en kommentar
Authors: Bennike Ole , Jensen Jørn Bo
Published: December 2024

Intet resumé
Tilbageblik ved et århundredeskifte
Authors: Poulsen Valdemar
Published: December 2024

Intet resumé
Ædle koraller: Rosenborgs korallerne - fortsat
Authors: Asgaard Ulla
Published: December 2024

Intet resumé
Orthoceratit i olie - en specialitet fra Ordovicium ved Kinnekulle
Authors: Buchardt Bjørn , Hansen Mette
Published: December 2024

Intet resumé
Nordrusland – et krydsfelt for istidens gletschere og nutiden kvartægeologer
Authors: Kjær Kurt H. , Funder Svend , Houmark-Nielsen Michael , Nielsen Jan K.
Published: December 2024

Intet resumé
Vulkanudbrud I 1995 på Fogo, Kap Verdeøerne
Authors: Holm Paul Martin , Kokfelt Thomas F. , Pedersen Lise E.
Published: December 2024

Intet resumé
Altiplano-Puna højsletten. Dannelseshistorie - en opdateret
Authors: Tychsen Anders
Published: December 2024

Intet resumé
De første spor på land – hvem satte dem egentlig?
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Upptäcksresande geologer, kvartäre djur och urinnevånare i sydligaste Sydamerika
Authors: Lilljequist Robert
Published: December 2024

Intet resumé
Blyisotoper – eksempler på deres
Authors: Frei Robert
Published: December 2024

Intet resumé
Dolkhaler, flyveøgler eller hoppende dinosaurer
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Gåden løses
Authors: Holm Eigil
Published: December 2024

Intet resumé
Enestående meteorit fra Mars til Geologisk Museum
Authors: Haack Henning
Published: December 2024

Intet resumé
Lauge Koch sagen – den danske geologstrid 1935-38
Authors: Ries Christopher Jacob
Published: December 2024

Intet resumé
Boganmeldelse. Karsten Secher: Det hvide guld og det ægte guld. Minedrift og råstoffer i Grønlands 20. århundrede, 64 sider. GEUS, 2004
Authors: Sørensen Henning
Published: December 2024

Intet resumé
Halkieria – et fossil fra Nedre Kambrium
Authors: Vinther Jakob
Published: December 2024

Intet resumé
Boganmeldelse. Erik Schou Jensen: Sten i farver, 6. udgave, 222 sider, Politikens Forlag
Authors: Sørensen Henning
Published: December 2024

Intet resumé
‘Tetrapteryx’ og flyvningens oprindelse. Tolkninger af de firevingede kinesiske dinosaurer
Authors: Hansen Kasper , Bonde Niels
Published: December 2024

Intet resumé
Boganmeldelse. Per Christiansen, Joakim Engel, Lotte Endsleff, Mikkel Høegh Post, Mikael Rothstein & Hanne Strager: Fjer, 115 sider.
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Boganmeldelse. Tom Vail (red): Grand Canyon – a different view, 104 sider
Authors: Håkansson Eckart
Published: December 2024

Intet resumé
Nowelizacja k.p.a. z 2017 roku a kary pieniężne za naruszenie zakazu praktyk ograniczających konkurencję
Authors:   SWPS Uniwersytet Humanistycznospołeczny z siedzibą w Warszawie: Interdyscyplinarne Studia Doktoranckie, Kulesza Marcin
Published: December 2024

Opracowanie poświęcone jest karom pieniężnym nakładanym przez Prezesa UOKiK na podstawie art. 106 i 106a ustawy z 16 lutego 2007 r. o ochronie konkurencji i konsumentów w kontekście wprowadzonych nowelizacją k.p.a. z 2017 r. przepisów ogólnych o karach administracyjnych. We wstępie przedstawiony został zakres nowelizacji k.p.a. oraz związek tej nowelizacji z przepisami dotyczącymi postępowania przed organem antymonopolowym i nakładania przez Prezesa UOKiK kar pieniężnych. W części drugiej omówiono pokrótce stanowiska orzecznictwa i doktryny co do charakteru prawnego kar antymonopolowych. W części trzeciej przedstawiono treść przepisów nowego działu IVa k.p.a., a w części czwartej dokonano oceny zakresu stosowania tych przepisów do kar antymonopolowych nakładanych na podstawie uokik z 2007 r. Podsumowanie opracowania określa wąski zakres stosowania przepisów ogólnych k.p.a. do omawianych kar oraz ich wpływ na ocenę charakteru prawnego kar antymonopolowych.
Energy sharing w świetle prawa Unii Europejskiej i sprawiedliwości energetycznej
Authors:   Uniwersytet Jagielloński, Hertie School of Governance, Kupiec Bartłomiej
Published: December 2024

Artykuł analizuje koncepcję współdzielenia energii, a jego celem jest zbadanie, w jaki sposób prawo Unii Europejskiej podchodzi do koncepcji współdzielenia energii i jej wpływu na osiągnięcie sprawiedliwości energetycznej wśród uczestników rynku energii. W artykule podjęto próbę odpowiedzi na pytanie, czy i w jaki sposób współdzielenie energii może przyczynić się do realizacji udziału obywateli w rynku energii w Unii Europejskiej. Struktura artykułu rozpoczyna się od rozważań na temat istoty współdzielenia energii i sprawiedliwości energetycznej. Autor zbadał interakcje pomiędzy współdzieleniem energii a sprawiedliwością energetyczną, analizując w jaki sposób praktyki współdzielenia energii, przewidziane w prawie UE, mogą wpływać na realizację sprawiedliwości energetycznej.
« Comme c’est un animal impur, on pourra le tuer ». La gestion des porcs dans les villes du Canada pendant la période française (1608-1763)
Authors: Riguelle William
Published: December 2024

À travers le cas des villes de Québec et de Montréal aux XVIIe et XVIIIe siècles, cet article propose de se pencher sur la législation relative aux cochons, d’éclairer les normes qui régulent leur présence en milieu urbain et d’analyser les motifs qui poussent à légiférer à leur encontre. Le porc est en effet un animal fréquemment ciblé par les édits de police sous le Régime français et fournit par conséquent une approche originale pour étudier l’histoire urbaine des premiers temps du Canada. Pour quel(s) motif(s) les porcs font-ils régulièrement l’objet de normes ? Quelles sont les répercussions de leur présence sur le territoire ? Comment les autorités gèrent-elles la cohabitation entre l’humain et l’animal ? Autant d’interrogations qui permettent de saisir, à travers cet agent non humain, la manière dont une société s’approprie, façonne, gère et conçoit son espace. Cet angle d’approche s’inscrit dans un courant de recherches qui, depuis les années 1980 essentiellement, met en avant l’intérêt de se focaliser sur l’animal et les discours à son égard pour étudier la société humaine et l’histoire urbaine.
Control of 3′ splice site selection by the yeast splicing factor Fyv6
Authors: Senn Katherine A , Lipinski Karli A , Zeps Natalie J , Griffin Amory F , Wilkinson Max E , Hoskins Aaron A
Published: December 2024

Pre-mRNA splicing is catalyzed in two steps: 5ʹ splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (first and second step factors). We recently identified Fyv6 (FAM192A in humans) as a second step factor in Saccharomyces cerevisiae; however, we did not determine how widespread Fyv6’s impact is on the transcriptome. To answer this question, we have used RNA sequencing (RNA-seq) to analyze changes in splicing. These results show that loss of Fyv6 results in activation of non-consensus, branch point (BP) proximal 3ʹ SS transcriptome-wide. To identify the molecular basis of these observations, we determined a high-resolution cryo-electron microscopy (cryo-EM) structure of a yeast product complex spliceosome containing Fyv6 at 2.3 Å. The structure reveals that Fyv6 is the only second step factor that contacts the Prp22 ATPase and that Fyv6 binding is mutually exclusive with that of the first step factor Yju2. We then use this structure to dissect Fyv6 functional domains and interpret results of a genetic screen for fyv6Δ suppressor mutations. The combined transcriptomic, structural, and genetic studies allow us to propose a model in which Yju2/Fyv6 exchange facilitates exon ligation and Fyv6 promotes usage of consensus, BP distal 3ʹ SS.
Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway
Authors: Yao Lan , Zhang Wanwan , Yang Xiaogang , Yi Meisheng , Jia Kuntong
Published: December 2024

Nodaviridae
infections cause severe mortality in insects and fish, with nervous necrosis virus (NNV) posing significant threats to global fish populations. However, the host factors involved in NNV entry remain poorly understood. Here, we identify myosin light chain 3 from marine medaka (
Oryzias melastigma
) (MmMYL3) as a novel receptor for red-spotted grouper NNV (RGNNV), facilitating internalization via macropinocytosis. MmMYL3 directly binds the RGNNV capsid protein (CP), which dependents on the arm and S domains of CP and the EF-hand2 domain of MmMYL3. In vitro experiments showed that MmMYL3 siRNA, protein, anti-MYL3 antibodies or the arm domain synthetic peptides blocked RGNNV entry. Moreover, in vivo administration of MmMYL3 protein also inhibited RGNNV infection. Ectopic MmMYL3 expression enabled RGNNV internalization into resistant cells. Notably, MmMYL3 facilitated RGNNV internalization through the macropinocytosis pathway via the IGF1R-Rac1/Cdc42 axis. Collectively, our findings underscore MYL3’s crucial role in NNV entry and its potential as an antiviral target.
Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics
Authors: Spargo Thomas P , Gilchrist Lachlan , Hunt Guy P , Dobson Richard JB , Proitsi Petroula , Al-Chalabi Ammar , Pain Oliver , Iacoangeli Alfredo
Published: December 2024

Continued methodological advances have enabled numerous statistical approaches for the analysis of summary statistics from genome-wide association studies. Genetic correlation analysis within specific regions enables a new strategy for identifying pleiotropy. Genomic regions with significant ‘local’ genetic correlations can be investigated further using state-of-the-art methodologies for statistical fine-mapping and variant colocalisation. We explored the utility of a genome-wide local genetic correlation analysis approach for identifying genetic overlaps between the candidate neuropsychiatric disorders, Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Parkinson’s disease, and schizophrenia. The correlation analysis identified several associations between traits, the majority of which were loci in the human leukocyte antigen region. Colocalisation analysis suggested that disease-implicated variants in these loci often differ between traits and, in one locus, indicated a shared causal variant between ALS and AD. Our study identified candidate loci that might play a role in multiple neuropsychiatric diseases and suggested the role of distinct mechanisms across diseases despite shared loci. The fine-mapping and colocalisation analysis protocol designed for this study has been implemented in a flexible analysis pipeline that produces HTML reports and is available at: https://github.com/ThomasPSpargo/COLOC-reporter.
A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model
Authors: Golov Arkadiy K , Gavrilov Alexey A , Kaplan Noam , Razin Sergey V
Published: December 2024

The enhancer-promoter looping model, in which enhancers activate their target genes via physical contact, has long dominated the field of gene regulation. However, the ubiquity of this model has been questioned due to evidence of alternative mechanisms and the lack of its systematic validation, primarily owing to the absence of suitable experimental techniques. In this study, we present a new MNase-based proximity ligation method called MChIP-C, allowing for the measurement of protein-mediated chromatin interactions at single-nucleosome resolution on a genome-wide scale. By applying MChIP-C to study H3K4me3 promoter-centered interactions in K562 cells, we found that it had greatly improved resolution and sensitivity compared to restriction endonuclease-based C-methods. This allowed us to identify EP300 histone acetyltransferase and the SWI/SNF remodeling complex as potential candidates for establishing and/or maintaining enhancer-promoter interactions. Finally, leveraging data from published CRISPRi screens, we found that most functionally verified enhancers do physically interact with their cognate promoters, supporting the enhancer-promoter looping model.
Restoring vestibular function during natural self-motion: Progress and challenges
Authors: Wiboonsaksakul Kantapon Pum , Leavitt Brown Olivia ME , Cullen Kathleen E
Published: December 2024

The vestibular system is integral to behavior; the loss of peripheral vestibular function leads to disabling consequences, such as blurred vision, dizziness, and unstable posture, severely limiting activities of daily living. Fortunately, the vestibular system’s well-defined peripheral structure and well-understood encoding strategies offer unique opportunities for developing sensory prostheses to restore vestibular function. While these devices show promising results in both animal models and implanted patients, substantial room for improvement remains. Research from an engineering perspective has largely focused on optimizing stimulation protocol to improve outcomes. However, this approach has often been pursued in isolation from research in neuroscience that has enriched our understanding of neural responses at the synaptic, cellular, and circuit levels. Accordingly, this review bridges the domains of neuroscience and engineering to consider recent progress and challenges in vestibular prosthesis development. We advocate for interdisciplinary approaches that leverage studies of neural circuits at the population level, especially in light of recent advancement in large-scale recording technology, to identify impediments still to overcome and to develop more naturalistic stimulation strategies. Fully integrating neuroscience and engineering in the context of prosthesis development will help advance the field forward and ultimately improve patient outcomes.
Åh, kom hid, Oh Satan!
Authors: Andersen Kraglund Rikke
Published: December 2024

I denne artikel analyseres Karl Ove Knausgårds roman Nattskolen (2023) med særligt fokus på den forbindelse romanen skaber mellem et selvmords- og et djævlepagtsmotiv. I romanen genbruger Knausgård fortællingen om sin egen vej til at blive kunstner fra Min kamp, men nu i et mørkere lys, hvor referencen til faustmyten træder tydeligere frem. Med en analyse af Nattskolens væv af referencer til både djævlepagter og Min kamp vil jeg vise, hvorledes romanen kan læses som en refleksion over prisen for at skabe kunst. At indgå en djævlepagt fortolkes i denne artikel som en form for selvmord, idet man er klar til at sælge sin sjæl og identitet for at tjene kunsten.
Kreativitet og destruksjon i Bjarte Breiteigs «Der nede sørger de ikke»
Authors: Brumo John
Published: December 2024

Hvordan kan vi forstå Bjarte Breiteigs novelle «Der nede sørger de ikke»? Novellen er en realistisk skildring av to ungdommer som tilsynelatende uten grunn raserer formingssalene på skolen. På et symbolsk nivå er hærverket imidlertid knyttet til forestillinger om selvmord, kreativitet og individualitet.
Introduksjon
Authors: Moi Ruben
Published: December 2024

"Selvmord og suicidal overlevelse", dette spesialnummeret av Nordlit, undersøker fremstillinger av den menneskelige eksistensens ytterpunkter, hovedsakelig i litteratur, men også i popmusikk, en TV-serie og en grafisk roman. Hvorfor tar enkelte mennesker livet sitt mens de fleste fortsetter å leve? Hva er selvmord og suicidalitet? Hvorfor presenterer litteratur og kunst en særegen mulighet til refleksjon og tolkning over selvmords- og overlevelsesproblematikk, og et alternativ til sosiologiske, filosofiske og psykologiske tilnærminger? Hva er en selvmordsroman? Denne introduksjonen og de tolv artiklene mediterer over slike spørsmål, og hvordan de kan formidles med kreativ utfoldelse og estetisk bevissthet.
Finnmark mellom øst og vest
Authors: Andreassen Reidun Laura
Published: December 2024

Denne artikkelen ser nærmere på de kulturelle og økonomiske forholdene i Finnmark under vikingtida og mellomalder, og hvordan de kan gi perspektiv på mangeromstuftenes funksjon og opphav. Fremstillingen tar utgangspunkt i arkeologiske funn og kulturminner i et område som geografisk er avgrenset fra Loppa i vest til Magerøya i nordøst.
Educação ambiental como princípio fundamental para formação de agentes multiplicadores numa escola de ensino fundamental em Pombal­PB
Authors: Sousa João Filipe Alves de , Sobrinho Luiz Gualberto de Andrade , Soares Ítalo José Dias , Almeida Yury Tibério Nunes , Silva Sandriel de Freitas Barbosa da , Jesus Gabriel Santos de
Published: December 2024

Este estudo investiga o uso de atividades interativas como ferramenta pedagógica para promover a Educação Ambiental (EA) entre alunos do quarto ano do ensino fundamental em Pombal-PB, Brasil. A pesquisa adota uma abordagem qualitativa, integrando revisão bibliográfica e aplicação prática por meio de palestras, jogos educativos, questionários e vídeos. As atividades buscaram estimular o interesse, a participação ativa e o compartilhamento de ideias entre os alunos, promovendo uma aprendizagem engajadora e contextualizada. Os resultados revelaram que 68% dos estudantes reconhecem a escola como a principal fonte de aprendizado ambiental, 29% demonstraram maior interesse na preservação da água, enquanto 33% relataram práticas de descarte adequado de resíduos. Além disso, 67% dos participantes associaram o aquecimento global tanto a ações humanas quanto a causas naturais, evidenciando uma compreensão inicial sobre o tema. As ilustrações e resenhas realizadas pelos alunos reforçam uma crescente sensibilização ambiental, destacando a importância de práticas educativas que conectem temas ambientais ao cotidiano dos estudantes. Observou-se que as atividades interativas, como os jogos “Animais em Extinção” e “Reciclando”, foram eficazes para ampliar o conhecimento e incentivar comportamentos sustentáveis. Apesar disso, foram identificadas limitações, como o tamanho reduzido da amostra e a necessidade de abordagens contínuas para mudanças comportamentais de longo prazo. Este estudo contribui para o campo da EA ao demonstrar que metodologias práticas e lúdicas podem ser replicadas em contextos educacionais diversos, promovendo a formação de cidadãos mais conscientes e comprometidos com a sustentabilidade.
Profitability of Maize and Groundnut Crop Production under Different Irrigation Systems with Varied Irrigation and Nitrogen Level Application in Southern India
Authors: Noorzai Aminullah , Suresh K. , Subbarao A.S. , Kumar K.A. , Reddy K.P.C. , Satish P.
Published: December 2024

An experiment was conducted to study the effects of irrigation systems, irrigation, and N levels on the economics of maize and groundnut during 2021-22 and 2022-23 at the College Farm, College of Agriculture, Rajendranagar, PJT Agricultural University, Hyderabad. The experiment consisted of 18 treatment combinations (3 irrigation systems as the main plot, 3 irrigation levels as the sub-plot, and 2 nitrogen levels as the sub-sub-plot) in a split plot design replicated thrice. The experiment revealed that among irrigation systems, irrigation, and N levels in both crops (maize and groundnut) significantly higher gross returns, net returns, and BCR were recorded with M2 (sub-surface irrigation system), S1 (1.2 Epan; IW/CPE) and N1 (100 percent RDN). In both crops, the interaction between irrigation system and irrigation levels (M x S) revealed significantly higher returns and BCR with sub-surface drip irrigation levels@ 1.2 Epan & 0.9 Epan ratios (M2S1 and M2S2) followed by surface drip irrigation levels @ 1.2 Epan & 0.9 Epan ratios (M1S1 and M1S2), surface irrigation @ 1.2 IW/CPE ratio (M3S1). In contrast, surface irrigation @ 0.6 IW/CPE ratio (M3S3) resulted in the least returns and BCR during both the years. The interaction effects of irrigation systems and N levels (M x N), irrigation, and N levels (S x N) were non-significant in the groundnut crop whereas they were significant in maize crop. The M2N1 recorded significantly higher mean gross returns (₹. 1,46,852 ha-1), net returns (₹. 90,960 ha-1), and BCR (2.62) whereas M3N2 recorded the lowest mean gross return (₹. 97,052 ha-1), net return (₹. 45,305 ha-1) and BCR (1.87). Among S x N interaction effects, the S1N1 (1.2 Epan; IW/CPE with 100 percent RDN) resulted in significantly higher gross returns (₹. 1,44,385 ha-1), net returns (₹. 89,256 ha-1) and BCR (2.61) followed by S2N1. In contrast, S3N2 resulted in significantly least returns and BCR. The interaction effects of irrigation systems, irrigation, and N levels (M x S x N) were non-significant in the groundnut crop while showing a significant impact on the economics of maize. The sub-surface irrigation system (M2) with 1.2 Epan (S1) and 100 percent RDN (N1) recorded significantly higher mean gross returns (₹. 1,58,749 ha-1), net return (₹. 1,10,243 ha-1) and BCR (2.82) followed by M2S2N1 (₹. 1,56,106 ha-1, ₹. 1,14,542 ha-1 and 2.79), M1S1N1 and M1S2N1 while M3S3N2 (surface irrigation system with 0.6 IW/CPE and 75 per cent RDN) recorded least mean gross returns (₹. 65,253 ha-1), net returns (₹. 14,106 ha-1) and BCR (1.28) thus making it the least remunerative among all treatment combinations studied.
Leverage, Profitability and Tax Avoidance: Transfer Pricing as a Moderating Variable
Authors: Gabriella Gabriella, , Lin Oktris,
Published: December 2024

This study analyzes the impact of leverage and profitability on tax avoidance, using transfer pricing as a moderating variable. The study focuses on manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2021-2023 period (3 years). Data were collected from the company's financial statements and analyzed using the Eviews application. The determination of the sample for this study was using the Purposive Sampling method and the analysis used panel data with the multiple regression method. The results of the study indicate that leverage has no effect on tax avoidance, profitability has a negative effect on tax avoidance, transfer pricing is able to positively moderate the effect of leverage and profitability on tax avoidance. The novelty of this study lies in the use of transfer pricing as a moderating variable in the relationship between leverage, profitability, and tax avoidance. This study provides a managerial contribution by identifying factors that influence tax avoidance and the role of transfer pricing in strengthening or weakening this influence. The results of this study are expected to be a reference for company management in formulating more effective and efficient financial policies in managing the company's tax burden.
The Ethical Paradox of Informed Consent in HPV Vaccination: Examining the Legal Boundaries and Ethical Considerations of Parental Consent, Public Health, and Individual Rights
Authors: Susilo Filia Clementy Daniast , Faridian Bagus , Nu’man Alexander Alif , Tyas Pradina Candraning , Firdaus Muhammad Luthfi
Published: December 2024

Background and Objective: Effective communication is crucial in medical procedures, and informed consent is a key example of this. However, informed consent may face unique circumstances, such as in life support situations or government health programs. The Human Papillomavirus (HPV) vaccination, as part of a government initiative, raises the question of whether informed consent is still required.  The study aims to explore whether informed consent is still necessary for the HPV vaccination and to analyze the legal implications if a citizen refuses to receive the vaccine. Patients have the right to refuse medical actions, making it essential to understand the legal consequences of rejecting the HPV vaccination.
Methods: This study adopts a normative juridical approach with an analytic descriptive specification. Secondary data was gathered from primary, secondary, and tertiary legal sources through literature reviews, document studies, and archival research. The collected data was then analyzed qualitatively and presented in a descriptive format.
Results: The study found that there are exceptions to the requirement for informed consent for vaccinations included in government programs. Specifically, informed consent is not necessary for individuals within the target age group of the government’s HPV vaccination program. In Indonesia, this program targets girls aged 9 to 14. Additionally, there are currently no legal penalties for individuals who refuse the HPV vaccination.
Conclusion: Informed consent is not required for individuals within the targeted age group of the government’s HPV vaccination program in Indonesia. Furthermore, there are no legal penalties for rejecting the vaccination.
Prediction of Soil Colour using Vis-NIR Spectroscopy and Machine Learning Models
Authors: Sahu Devid Kumar , Sharma Y. M. , Tagore G. S. , Kulhare P. S. , Nema R.K. , Sahu R. K.
Published: December 2024

Soil colour is a critical indicator of soil properties and conditions, influencing various agronomic and environmental factors. A total of 2216 surface soil samples (0-15 cm) were collected from the Kymore Plateau and Satpura Hill zone of Madhya Pradesh, using Global Positioning System (GPS) for precise location. Soil colour parameters were measured in the field using the Munsell soil colour chart, while chemical analysis was conducted in the laboratory following standard procedures. Additionally, spectra of the soil samples were recorded using a spectroradiometer under laboratory conditions.
The results showed that the soil colour hues ranged from 10R, 10YR, 2.5Y, 2.5YR, 5Y, 5R, 5YR, to 7.5YR, Values and Chroma varied from 2 to 7 and 1 to 8, respectively. Correlation analysis revealed negative correlations between the RGB components and organic carbon, with r values of -0.114**, -0.071**, and -0.101* for R, G, and B, respectively. Polynomial models showed the best fit for the relationship between the value and chroma of the colour parameters and soil organic carbon (SOC), with equations Y = 0.086x² - 0.860x + 7.528 (R² = 0.982) and Y = 0.018x² - 0.249x + 6.126 (R² = 0.948), respectively. A linear relationship was observed between chroma and available phosphorus (P), with the equation Y = -0.873 + 13.92 (R² = 0.922).
In addition, machine learning models, including PLSR, SVM, Random Forest, ANN, XGBoost, LightGBM, CatBoost, and ELM algorithms, were used to predict soil colour parameters. Among these, the Random Forest and XGBoost models demonstrated the best performance in predicting soil colour parameters (L*, a*, b*, R, G, and B), with model accuracies of 83.6%, 80.9%, 83.0%, 84.3%, 83.7%, and 83.4%, respectively. soil colour variation depicted in the maps generated using GIS can also serve as covariates for  mapping, offering comprehensive insights into the soil's properties.
Advancements in Palynology: Enhancing Plant Breeding through Pollen Studies
Authors: Vankalas. Chaitanya N. , Nanekar. Snehal K. , Patil. Pooja B. , Khore. Tejashri T.
Published: December 2024

Palynology, the study of pollen and spores, has emerged as a vital discipline in plant science, with applications extending into plant breeding. This review explores the role of palynology in understanding reproductive biology, enhancing breeding programs, overcoming hybridization barriers and addressing challenges like male sterility, stress tolerance and species compatibility. Advanced techniques like transcriptomics reveal gene expression profiles, while proteomics and metabolomics provide insights into fertility and stress responses. Pollen-mediated transformation and CRISPR-Cas9 gene editing facilitate targeted trait improvements, with pollen-specific promoters aiding hybrid breeding. Additionally, molecular tools support pollen viability testing, gene flow studies, and stress tolerance research, contributing to hybrid seed production and environmental adaptability. Palynology also ensures biosafety by tracking transgenic pollen, making it an integral component of sustainable crop improvement strategies.
Case studies illustrate its impact on cereals, legumes and horticultural crops. The article concludes by highlighting challenges and future directions for integrating palynological studies with emerging technologies to improve plant breeding outcomes. Plant breeding aims to develop superior crop varieties with desirable traits such as higher yields, resistance to biotic and abiotic stresses, improved quality and adaptability to diverse environments. Successful breeding hinges on understanding the reproductive biology of plants, particularly pollen, which serves as the carrier of male gametes.
Strategic Public Relations: Illuminating Corporate Visibility of Higher Learning Institutions in Tanzania through Internal Influence, Internal Collaboration, Media Engagement and Stakeholder’s Confidence
Authors: Dachi Kahenga Hillary , Tibaijuka Albert , Ngaruko Deus
Published: December 2024

In a current state where the international higher education system has put colleges and universities under pressure of acquiring resources, corporate visibility has become vital for their sustainability and survival. This study aims at exploring the role public relations strategies can play on corporate visibility, focusing on four key themes namely internal influence, internal collaboration, media engagement and stakeholder confidence. Using a qualitative research approach, data were collected from 26 participants through in-depth interviews and supplemented by the review of relevant institutional documents. The findings reveal that internal influence magnified by effective communication play essential role in shaping the corporate visibility of the institution among the public. Internal collaboration, particularly with the management, employees and students emerged as key analytical strategy for extending the institution’s reach and influence. Also findings reveal that media engagement was a powerful tool for amplifying the institution’s achievements and initiatives, while stakeholder confidence was found to be essential in sustaining long-term corporate visibility and credibility of the institution. This study contributes to the understanding of how public relations strategies can be effectively used to illuminate the corporate visibility of Higher Learning Institutions (HLIs) particularly in Tanzania. The insights gained provide practical implications for HLIs and public relations seeking to manage the complexities of reputation management in the education sector. The study further recommends future research to explore these themes in diverse institutional contexts.
Comparison of the Structures and Antioxidant Activity of the Major Compounds of Lippia multiflora Mold (Verbenaceae) Leaves Essential Oils Collected in Center of Côte d'Ivoire
Authors: ATCHE Philatryho , SOUMAHORO Brahima , SANOU Ferdinand Sibiri , KASSI Amian Brise Benjamin , SORO Yaya
Published: December 2024

The growing interest in natural antioxidants is motivated by the harmful effects of the use of synthetic antioxidants. Medicinal plants such as Lippia multiflora are being studied for their multiple biological potentials, in particular their ability to provide new sources of natural antioxidants. The aim of this study was to determine the chemical composition and assess the antioxidant activity of Lippia multiflora essential oils from five (5) localities in Côte d'Ivoire. The essential oils were extracted by steam stripping and analyzed by gas chromatography-mass spectrometry (GC-MS) to determine their chemical composition. Their antioxidant activity was assessed using DPPH and ABTS tests.The analyses revealed that the major compounds in the essential oils from Yamoussoukro, Tiébissou, Bouaflé, Toumodi and Dimbokro were α-phellandrene, Eucalyptol (1,8-cineole), Linalool, β-citral (Neral), trans-geraniol, α-citral (Geranial), Germacrene D and (±)-trans-nerolidol, respectively. The best antioxidant activities for the DPPH and ABTS tests were obtained for Dimbokro and Toumodi essential oils respectively. These results suggest that Lippia multiflora essential oils have significant biological potential and could be used as an alternative to synthetic antioxidants, with possible applications in the agri-food and pharmaceutical industries.