bluuebunny/crossref_metadata_2025 huggingface dataset:
Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology
Authors: Rastoldo Guillaume , Tighilet Brahim
Published: June 2023

A recent work of our group has shown the significant effects of thyroxine treatment on the restoration of postural balance function in a rodent model of acute peripheral vestibulopathy. Based on these findings, we attempt to shed light in this review on the interaction between the hypothalamic–pituitary–thyroid axis and the vestibular system in normal and pathological situations. Pubmed database and relevant websites were searched from inception through to 4 February 2023. All studies relevant to each subsection of this review have been included. After describing the role of thyroid hormones in the development of the inner ear, we investigated the possible link between the thyroid axis and the vestibular system in normal and pathological conditions. The mechanisms and cellular sites of action of thyroid hormones on animal models of vestibulopathy are postulated and therapeutic options are proposed. In view of their pleiotropic action, thyroid hormones represent a target of choice to promote vestibular compensation at different levels. However, very few studies have investigated the relationship between thyroid hormones and the vestibular system. It seems then important to more extensively investigate the link between the endocrine system and the vestibule in order to better understand the vestibular physiopathology and to find new therapeutic leads.
Synthesis of Brominated Lactones Related to Mycalin A: Selective Antiproliferative Activity on Metastatic Melanoma Cells and Inhibition of the Cell Migration
Authors: Capasso Domenica , Marino Paola , Di Gaetano Sonia , Borbone Nicola , Terracciano Monica , Trani Roberta , Longo Caterina , Piccialli Vincenzo
Published: June 2023

Starting from D-xylonolactone and D-ribonolactone, several five-membered bromolactones, related to the C1–C5 portion of mycalin A lactone, have been synthesized. The bromination of D-ribonolactone with HBr/AcOH, without a subsequent transesterification step, has been studied for the first time, giving us most of the acetylated lactones investigated in the present study. For each compound, where possible, both the C-3 alcohol and the corresponding acetate were prepared. Evaluation of their anti-tumor activity showed that all the acetates possess a good cytotoxicity towards human melanoma (A375), human cervical adenocarcinoma (HeLa) and human metastatic melanoma (WM266) cancer cells, comparable or even higher than that displayed by the original mycalin A lactone. Lactone acetates derived from D-ribonolactone showed the higher selectivity of action, exhibiting a strong cytotoxicity on all the tested tumor cells but only a limited toxicity on healthy human dermal fibroblast (HDF) cells, used as a control. Wound healing assays showed that two of these substances inhibit the migration of the WM266 cells.
Development of Photothermal Catalyst from Biomass Ash (Bagasse) for Hydrogen Production via Dry Reforming of Methane (DRM): An Experimental Study
Authors: Kanchanakul Ittichai , Srinophakun Thongchai Rohitatisha , Kuboon Sanchai , Kaneko Hiroaki , Kraithong Wasawat , Miyauchi Masahiro , Yamaguchi Akira
Published: June 2023

Conventional hydrogen production, as an alternative energy resource, has relied on fossil fuels to produce hydrogen, releasing CO2 into the atmosphere. Hydrogen production via the dry forming of methane (DRM) process is a lucrative solution to utilize greenhouse gases, such as carbon dioxide and methane, by using them as raw materials in the DRM process. However, there are a few DRM processing issues, with one being the need to operate at a high temperature to gain high conversion of hydrogen, which is energy intensive. In this study, bagasse ash, which contains a high percentage of silicon dioxide, was designed and modified for catalytic support. Modification of silicon dioxide from bagasse ash was utilized as a waste material, and the performance of bagasse ash-derived catalysts interacting with light irradiation and reducing the amount of energy used in the DRM process was explored. The results showed that the performance of 3%Ni/SiO2 bagasse ash WI was higher than that of 3%Ni/SiO2 commercial SiO2 in terms of the hydrogen product yield, with hydrogen generation initiated in the reaction at 300 °C. Using the same synthesis method, the current results suggested that bagasse ash-derived catalysts had better performance than commercial SiO2-derived catalysts when exposed to an Hg-Xe lamp. This indicated that silicon dioxide from bagasse ash as a catalyst support could help improve the hydrogen yield while lowering the temperature in the DRM reaction, resulting in less energy consumption in hydrogen production.
Assisted Reductive Amination for Quantitation of Tryptophan, 5-Hydroxytryptophan, and Serotonin by Ultraperformance Liquid Chromatography Coupled with Tandem Mass Spectrometry
Authors: Liang Shih-Shin , Shen Po-Tsun , Liang Yu-Qing , Ke Yi-Wen , Cheng Chieh-Wen , Lin Yi-Reng
Published: June 2023

Herein, we used isotopic formaldehyde and sodium cyanoborohydride via reductive amination to label two methyl groups on primary amine to arrange the standards (h2-formaldehyde-modified) and internal standards (ISs, d2-formaldehyde-modified) of tryptophan and its metabolites, such as serotonin (5-hydroxytryptamine) and 5-hydroxytryptophan. These derivatized reactions with a high yield are very satisfactory for manufacturing standards and ISs. This strategy will generate one or two methyl groups on amine to create different mass unit shifts with 14 vs. 16 or 28 vs. 32 in individual compounds for biomolecules with amine groups. In other words, multiples of two mass units shift are created using this derivatized method with isotopic formaldehyde. Serotonin, 5-hydroxytryptophan, and tryptophan were used as examples to demonstrate isotopic formaldehyde-generating standards and ISs. h2-formaldehyde-modified serotonin, 5-hydroxytryptophan, and tryptophan are standards to construct calibration curves, and d2-formaldehyde-modified analogs such as ISs spike into samples to normalize the signal of each detection. We utilized multiple reaction monitoring modes and triple quadrupole mass spectrometry to demonstrate the derivatized method suitable for these three nervous biomolecules. The derivatized method demonstrated a linearity range of the coefficient of determinations between 0.9938 to 0.9969. The limits of detection and quantification ranged from 1.39 to 15.36 ng/mL.
8(meso)-Pyridyl-BODIPYs: Effects of 2,6-Substitution with Electron-Withdrawing Nitro, Chloro, and Methoxycarbonyl Groups
Authors: Ndung’U Caroline , Bobadova-Parvanova Petia , LaMaster Daniel J. , Goliber Dylan , Fronczek Frank R. , Vicente Maria da Graça H.
Published: June 2023

The introduction of electron-withdrawing groups on 8(meso)-pyridyl-BODIPYs tends to increase the fluorescence quantum yields of this type of compound due to the decrease in electronic charge density on the BODIPY core. A new series of 8(meso)-pyridyl-BODIPYs bearing a 2-, 3-, or 4-pyridyl group was synthesized and functionalized with nitro and chlorine groups at the 2,6-positions. The 2,6-methoxycarbonyl-8-pyridyl-BODIPYs analogs were also synthesized by condensation of 2,4-dimethyl-3-methoxycarbonyl-pyrrole with 2-, 3-, or 4-formylpyridine followed by oxidation and boron complexation. The structures and spectroscopic properties of the new series of 8(meso)-pyridyl-BODIPYs were investigated both experimentally and computationally. The BODIPYs bearing 2,6-methoxycarbonyl groups showed enhanced relative fluorescence quantum yields in polar organic solvents due to their electron-withdrawing effect. However, the introduction of a single nitro group significantly quenched the fluorescence of the BODIPYs and caused hypsochromic shifts in the absorption and emission bands. The introduction of a chloro substituent partially restored the fluorescence of the mono-nitro-BODIPYs and induced significant bathochromic shifts.
Three New Benzophenone Derivatives from Selaginella tamariscina
Authors: Long Jiayin , Mao Qingqing , Peng Yujie , Liu Lei , Hong Yin , Xiang Honglin , Ma Ming , Zou Hui , Kuang Junwei
Published: June 2023

Six compounds including three new benzophenones, selagibenzophenones D-F (1–3), two known selaginellins (4–5) and one known flavonoid (6), were isolated from Selaginella tamariscina. The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound 1 represents the second example of diarylbenzophenone from natural sources. Compound 2 possesses an unusual biphenyl-bisbenzophenone structure. Their cytotoxicity against human hepatocellular carcinoma HepG2 and SMCC-7721 cells and inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compound 2 showed moderate inhibitory activity against HepG2 and SMCC-7721 cells, and compounds 4 and 5 showed moderate inhibitory activity to HepG2 cells. Compounds 2 and 5 also exhibited inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production.
Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems
Authors: Nova Paulo , Pimenta-Martins Ana , Maricato Élia , Nunes Cláudia , Abreu Helena , Coimbra Manuel A. , Freitas Ana Cristina , Gomes Ana Maria
Published: June 2023

In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined. Protein, carbohydrates, and fat contents ranged between 12.4% and 41.8%, 27.6% and 42.0%, and 0.1% and 3.4%, respectively. The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile. Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida. Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS. The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
Adsorption of Omeprazole on Biobased Adsorbents Doped with Si/Mg: Kinetic, Equilibrium, and Thermodynamic Studies
Authors: Teixeira Roberta A. , Thue Pascal S. , Lima Éder C. , Grimm Alejandro , Naushad Mu. , Dotto Guilherme L. , dos Reis Glaydson S.
Published: June 2023

This paper proposes an easy and sustainable method to prepare high-sorption capacity biobased adsorbents from wood waste. A biomass wood waste (spruce bark) was employed to fabricate a composite doped with Si and Mg and applied to adsorb an emerging contaminant (Omeprezole) from aqueous solutions, as well as synthetic effluents loaded with several emerging contaminants. The effects of Si and Mg doping on the biobased material’s physicochemical properties and adsorptive performance were evaluated. Si and Mg did not influence the specific surface area values but impacted the presence of the higher number of mesopores. The kinetic and equilibrium data presented the best fitness by the Avrami Fractional order (AFO) and Liu isotherm models, respectively. The values of Qmax ranged from 72.70 to 110.2 mg g−1 (BP) and from 107.6 to 249.0 mg g−1 (BTM). The kinetic was faster for Si/Mg-doped carbon adsorbent, possibly due to different chemical features provoked by the doping process. The thermodynamic data showed that the adsorption of OME on biobased adsorbents was spontaneous and favorable at four studied temperatures (283, 293, 298, 303, 308, 313, and 318 K), with the magnitude of the adsorption correspondent to a physical adsorption process (ΔH° < 2 kJ mol−1). The adsorbents were applied to treat synthetic hospital effluents and exhibited a high percentage of removal (up to 62%). The results of this work show that the composite between spruce bark biomass and Si/Mg was an efficient adsorbent for OME removal. Therefore, this study can help open new strategies for developing sustainable and effective adsorbents to tackle water pollution.
Nobiletin with AIEE Characteristics for Targeting Mitochondria and Real-Time Dynamic Tracking in Zebrafish
Authors: Jin Tingting , Li Na , Wu Yi , He Ying , Yang Depo , He Feng
Published: June 2023

Nobiletin is a natural product with multiple physiological activities and is the main ingredient of Pericarpium Citri Reticulatae. We successfully discovered that nobiletin exhibits aggregation induced emission enhancement (AIEE) properties and it has significant advantages such as a large Stokes shift, good stability and excellent biocompatibility. The increase in methoxy groups endows nobiletin a greater fat-solubility, bioavailability and transport rate than the corresponding unmethoxylated flavones. Ulteriorly, cells and zebrafish were used to explore the application of nobiletin in biological imaging. It emits fluorescence in cells and is specifically targeted at mitochondria. Moreover, it has a noteworthy affinity for the digestive system and liver of zebrafish. Due to the unique AIEE phenomenon and stable optical properties of nobiletin, it paves the way for discovering, modifying and synthesizing more molecules with AIEE characteristics. Furthermore, it has a great prospect with regard to imaging cells and cellular substructures, such as mitochondria, which play crucial roles in cell metabolism and death. Indeed, three-dimensional real-time imaging in zebrafish provides a dynamic and visual tool for studying the absorption, distribution, metabolism and excretion of drugs. In this article, more directions and inspiration can be presented for the exploration of non-invasive pharmacokinetic research and intuitive drug pathways or mechanisms.
Graphene Oxide/Nitrocellulose Non-Covalent Hybrid as Solid Phase for Oligo-DNA Extraction from Complex Medium
Authors: Toader Georgian A. , Nitu Florentin R. , Ionita Mariana
Published: June 2023

A nitrocellulose–graphene oxide hybrid that consists of a commercially nitrocellulose (NC) membrane non-covalently modified with graphene oxide (GO) microparticles was successfully prepared for oligonucleotide extraction. The modification of NC membrane was confirmed by Fourier Transform Infrared Spectroscopy (FTIR), which highlighted the principal absorption bands of both the NC membrane at 1641, 1276, and 835 cm−1 (NO2) and of GO in the range of 3450 cm−1 (CH2-OH). The SEM analysis underlined the well-dispersed and uniform coverage of NC membrane with GO, which displayed thin spider web morphology. The wettability assay indicated that the NC–GO hybrid membrane exhibited slightly lower hydrophilic behavior, with a water contact angle of 26.7°, compared to the 15° contact angle of the NC control membrane. The NC–GO hybrid membranes were used to separate oligonucleotides that had fewer than 50 nucleotides (nt) from complex solutions. The features of the NC–GO hybrid membranes were tested for extraction periods of 30, 45, and 60 min in three different complex solutions, i.e., an aqueous medium, an α-Minimum Essential Medium (αMEM), and an αMEM supplemented with fetal bovine serum (FBS). The oligonucleotides were desorbed from the surface of the NC–GO hybrid membrane using Tris-HCl buffer with a pH of 8.0. Out of the three media utilized, the best results were achieved after 60 min incubation of the NC–GO membranes in αMEM, as evidenced by the highest fluorescence emission of 294 relative fluorescence units (r.f.u.). This value corresponded to the extraction of approximately 330–370 pg (≈7%) of the total oligo-DNA. This method is an efficient and effortless way to purify short oligonucleotides from complex solutions.
Evaluation of Real-World Vancomycin Dosing and Attainment of Therapeutic Drug Monitoring Targets
Authors: Bradley Nicole , Ng Kimberly
Published: June 2023

In 2020, the Infectious Diseases Society of America (IDSA) recommended a change in vancomycin therapeutic drug monitoring from trough-based to AUC/MIC-based to optimize vancomycin’s efficacy and reduce nephrotoxicity. Many hospitals have not implemented this change due to barriers such as the cost of AUC/MIC software and lack of provider familiarity. The purpose of this study was to determine the rate of AUC/MIC ratio target attainment using current trough-based vancomycin dosing practices at a city hospital. The rates of acute kidney injury (AKI) were also evaluated. Vancomycin orders were reviewed retrospectively to determine the expected AUC/MIC ratios using first-order pharmacokinetic equations over a 7-month period. Orders were excluded if they were written for a one-time dose, for individuals less than 18 years of age, or for those on hemodialysis. A total of 305 vancomycin orders were included in this review. Overall, 27.9% (85/305) of vancomycin orders attained the AUC/MIC ratio target of 400–600 mg·h/L as recommended by the guidelines. Nearly 35% (106/305) achieved AUC/MIC ratios below 400 mg·h/L and 37.4% (114/305) achieved AUC/MIC ratios above 600 mg·h/L. Orders for obese patients were significantly more likely to have below the target AUC/MIC ratios (68% vs. 23.9%, X2 48.48, p < 0.00001) and non-obese patients were significantly more likely to have above the target AUC/MIC ratios (45.7% vs. 12%, X2 27.36, p < 0.00001). The overall rate of acute kidney injury observed was 2.6%. Most vancomycin orders did not attain therapeutic drug monitoring targets, reflecting the ongoing clinical challenge of optimizing vancomycin doses and implementing new guideline recommendations.
Improvement of Chitosan Films Properties by Blending with Cellulose, Honey and Curcumin
Authors: Madian Noha G. , El-Ashmanty Basant A. , Abdel-Rahim Hadeel K.
Published: June 2023

Chitosan is a natural biopolymer that can be used in biomedical applications, tissue engineering, and wound dressing because of its biodegradability, biocompatibility, and antibacterial activity. The blending of chitosan films with natural biomaterials such as cellulose, honey, and curcumin was studied at different concentrations in order to improve their physical properties. Fourier transform infrared (FTIR) spectroscopy, mechanical tensile properties, X-ray diffraction (XRD), antibacterial effects, and scanning electron microscopy (SEM) were studied for all blended films. The XRD, FTIR, and mechanical results showed that films blended with curcumin were more rigid and compatible and had higher antibacterial effects than other blended films. In addition, XRD and SEM showed that blending chitosan films with curcumin decreases the crystallinity of the chitosan matrix compared to cellulose and honey blending films due to increased intermolecular hydrogen bonding, which reduces the close packing of the CS matrix.
The Contribution of Society of Social Psychiatry P. Sakellaropoulos to the Psychiatric Reform in Rural Greece
Authors: Papachristou Harilaos , Lazogiorgou-Kousta Iliana , Chronopoulos Vasilis , Fragouli-Sakellaropoulou Athena
Published: June 2023

The present paper aims to describe the structure, function, and goals of two of the oldest Mobile Mental Health Units in Greece, namely, the Mobile Mental Health Unit in Fokida (MMHU-F) and the Mobile Mental Health Unit in Thrace (Alexandroupolis, MMHU-T). Information about their historical background, catchment areas, and current staffing, as well as the services provided by each MMHU is discussed. The focus of the paper is slightly biased towards the MMHU-F because it is the only available mental health service in the whole Fokida prefecture. The major goals of the MMHUs are the diagnosis, treatment, and prevention of relapse of severe mental illness within the community. Other important goals of the MMHUs are psychoeducation, psychological support for the family/caregivers, as well as vocational training and support for patients with severe mental illness. Statistical data depicting the demographic characteristics and diagnostic profiles of patients in each MMHU is also provided, and the differences between the two MMHUs are briefly discussed.
Exploiting Light Polarization for Deep HDR Imaging from a Single Exposure
Authors: Pistellato Mara , Fatima Tehreem , Wimmer Michael
Published: June 2023

In computational photography, high dynamic range (HDR) imaging refers to the family of techniques used to recover a wider range of intensity values compared to the limited range provided by standard sensors. Classical techniques consist of acquiring a scene-varying exposure to compensate for saturated and underexposed regions, followed by a non-linear compression of intensity values called tone mapping. Recently, there has been a growing interest in estimating HDR images from a single exposure. Some methods exploit data-driven models trained to estimate values outside the camera’s visible intensity levels. Others make use of polarimetric cameras to reconstruct HDR information without exposure bracketing. In this paper, we present a novel HDR reconstruction method that employs a single PFA (polarimetric filter array) camera with an additional external polarizer to increase the scene’s dynamic range across the acquired channels and to mimic different exposures. Our contribution consists of a pipeline that effectively combines standard HDR algorithms based on bracketing and data-driven solutions designed to work with polarimetric images. In this regard, we present a novel CNN (convolutional neural network) model that exploits the underlying mosaiced pattern of the PFA in combination with the external polarizer to estimate the original scene properties, and a second model designed to further improve the final tone mapping step. The combination of such techniques enables us to take advantage of the light attenuation given by the filters while producing an accurate reconstruction. We present an extensive experimental section in which we validate the proposed method on both synthetic and real-world datasets specifically acquired for the task. Quantitative and qualitative results show the effectiveness of the approach when compared to state-of-the-art methods. In particular, our technique exhibits a PSNR (peak signal-to-noise ratio) on the whole test set equal to 23 dB, which is 18% better with respect to the second-best alternative.
Resolución de problemas aditivos en estudiantes de primaria de la zona rural durante la pandemia
Authors: Reyes Castillo Ayde , Oblitas Bravo Ever
Published: June 2023

La problemática que enfrentan las escuelas rurales de educación primaria en el área de las matemáticas, motivó este estudio donde el objetivo fue analizar la resolución de problemas aditivos en los estudiantes de educación básica de la zona rural en época de pandemia durante el año 2021. Se realizó bajo una metodología cuantitativa y enfoque descriptivo, diseño no experimental, los participantes fueron 60 alumnos entre 7 y 8 años, quienes se encontraban cursando el segundo grado de educación básica en la Institución Educativa N°80930, ubicada en Julcán rural, departamento de la Libertad en Perú. Se usó la prueba PAEVSO” (Problemas Aritméticos Verbales de una Sola Operación). Los resultados mostraron en el caso de la variable resolución de problemas aditivos un 41.7% de los participantes se ubicó en proceso, seguido de 26.7 % en logro previsto. Como parte de las conclusiones se determinó que los problemas aditivos de igualación son los que obtuvieron los mejores resultados, seguidos de los problemas de combinación.
El tecnoestrés en el rendimiento académico en estudiantes
Authors: Ponce Pardo John Eloy , Hernández Guerra Reyna Emperatriz , Jalixto Erazo Hans Manuel , Chiri Saravia Paulo Cesar
Published: June 2023

La tecnología incide en el aprendizaje del estudiante, favorece el acceso a la información, a programas académicos virtuales, y el constante uso de redes sociales no pasa desapercibido. Esto hace que el estudiante dependa más de las Tecnologías de la Información y Comunicación. Por ello, el objetivo fue analizar como el tecnoestrés influye en el rendimiento académico de los estudiantes. Se realizó un estudio de diseño correlacional de corte transversal bajo un análisis cuantitativo con una muestra de 251 estudiantes de una universidad nacional. El instrumento empleado fue la escala de Likert. En los resultados se constató el 49.40% presenta un tecnoestrés en un nivel medio, el 28.69% bajo y el 21.91% alto. Se concluyó que el nivel de tecnoestrés tiene una influencia significativa e inversa en el rendimiento académico de los estudiantes. El impacto negativo de alto niveles de estrés puede ser contrarrestado por un alto nivel de autoeficacia tecnológica.
Pengaruh Ambient Interior Cafe Terhadap Pemilihan Tempat Bekerja Remote Worker di Era Pandemi COVID-19
Authors: Sri Wahyuni Trisna Ni Made , Utami Ni Kadek Yuni , Effendi Nabil Rahman
Published: June 2023

Pandemi COVID-19 membuat fenomena bekerja di luar kantor semakin diminati oleh masyarakat, khususnya para remote worker - orang yang bekerja dari manapun. Kenyamanan sebuah café saat pandemi menjadi hal penting untuk diperhatikan, dalam hal ini ambient interior melalui cahaya, suara, dan suhu cafe. Ambient interior dipercaya turut mempengaruhi psikologis pengunjung sehingga dapat memberi rasa nyaman saat bekerja. Penelitian ini bertujuan untuk mengetahui pengaruh ambient interior cafe di era pandemi, seperti pencahayaan, suara dan suhu sebagai preferensi pemilihan tempat bekerja oleh para remote worker. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan melakukan kuesioner terhadap 50 remote workers untuk mengetahui pengaruh ambient interior terhadap pemilihan tempat bekerja saat pandemi. Selain itu dilakukan observasi langsung pada tiga cafe populer yang terdapat di daerah Ubud  yaitu Ruster Cafe, Milk and Madu, dan Monsieur Spoon untuk melihat perubahan ambient interior yang dilakukan saat pandemi. Data hasil kuesioner dianalisis dan menunjukkan hasil bahwa pertimbangan ambient interior berupa cahaya, suara dan suhu yang dapat memberikan perasaan aman dan nyaman terhadap penyebaran virus COVID-19 sangat berpengaruh terhadap pemilihan tempat bekerja oleh para remote worker saat pandemi. Penelitian ini diharapkan memberi manfaat kepada pengelola atau pemilik cafe untuk mempertimbangkan pentingnya ambient interior pada cafe.

 

Kata Kunci: Ambient Interior, Cafe, Pandemi COVID-19, Remote Workers
ENTREVISTA COM A PROFESSORA ELAINE LOURENÇO
Authors: Chalegre Laura
Published: June 2023

Entrevista com a Profa. Dra. Elaine Lourenço, professora do Departamento de História da Universidade Federal de São Paulo (UNIFESP), atuando nos cursos de Licenciatura e Bacharelado, além do Mestrado Profissional em Ensino de História - ProfHistória.
Narrative Analysis Research: A Tool for Extension Educators
Authors: Cowger Tina , Tritz Julie
Published: June 2023

Within the qualitative research community, narrative analysis research is a common method that is used to better understand a person's experiences or a collective experience. The use of narratives in Extension has been limited. Extension professionals primarily have used narratives as tools for conveying the value of Extension programs or, more recently, as one aspect of a broader program evaluation effort. This article focuses on benefits of narrative analysis research and its potential for practical application by those in Extension.
Creating a Suicide Prevention Program for Farmers and Farmworkers
Authors: McMoran Don , Seymour Kate , Bachtel Shannon , Thorstenson Sylvi
Published: June 2023

In 2018 the Washington State legislature passed Substitute House Bill 2671 to address suicide in the agriculture industry, and Washington State University Skagit County Extension was selected by the Washington State Department of Health to develop a suicide prevention pilot program for farmers and farmworkers. In the initial stage from March to September 2019, program efforts included collaborating with suicide prevention and behavioral health experts, building institutional capacity (bilingual English–Spanish material and website creation), and leveraging the Extension platform. We provide a roadmap for other Extension entities looking to create suicide prevention programs.
Preparing Extension Educators for Community-Based Research and Grant Partnerships
Authors: Eschbach Cheryl , Tiret Holly , Carter Erin , Newkirk Cathy
Published: June 2023

Two trainings to prepare Extension educators for research and grant partnerships were designed, implemented, and evaluated. These trainings further national goals to address health disparities, gain partnerships in the health care sector, and support health extension. The workshop Are You Research Ready? prepares Extension educators to participate in community-based human health research. Evaluations indicated that attendees gained a self-assessment of research readiness and felt more confident to position themselves for grants. Program evaluations also showed that educators needed additional training on how to create partnerships. A second workshop, Are You Partnership Ready?, addresses this need, increasing participants' confidence and skills for engaging in research projects and building partnerships.
Sowing Seeds of Evaluation: A Pilot Study Measuring Master Gardener Program Public Benefit
Authors: Wilkins Tamekia , Gable Melissa , Alviz Kit , Martinez Katherine , Womack Melissa
Published: June 2023

We conducted an evaluation pilot study to measure the influence of the statewide University of California Master Gardener Program on participants who attended its public education events. We discuss (a) steps for developing a statewide evaluation and (b) findings from the event follow-up survey we used to evaluate public education participants' self-reported behavior changes. Our findings suggest that volunteer-led public education events resulted in participants improving science-based gardening practices. Our approach has implications for other states' Extension programs; sharing program evaluation measurement strategies and data across states can facilitate better communicating Extension's benefit to the public, thereby addressing a need identified in the literature.
Photo Elicitation: Useful Supplemental Tool for Qualitative Interviews with Youths
Authors: Mott Rebecca , Tummons John , Simonsen Jon , Vandermau Roxanne
Published: June 2023

Photo elicitation is the idea of inserting a photograph (or other visual material) into a research interview. It has been documented that contemporary modes of expression (such as photographs) can be beneficial in research interviews with youths. This article describes a photo elicitation protocol used with older youths and provides insight on the benefits and challenges of using photo elicitation for qualitative research purposes.
Effects of Porosity on Piezoelectric Characteristics of Polyvinylidene Fluoride Films for Biomedical Applications
Authors: Kloster Jack T. , Danley Matthew J. , Lai Victor K. , Zhao Ping
Published: June 2023

Objective
: The objective of this work is to study the effects of porosity on mechanical and piezoelectric properties of polyvinylidene fluoride (PVDF) films for biomedical applications.
Impact Statement:
By investigating the piezoelectric properties of PVDF and the porosity effect on its electromechanical performance, there is potential for further development of PVDF as a hemodynamic sensor that can lead to further technological advancements in the biomedical field, benefiting patients and physicians alike.
Introduction
: PVDF thin films have shown potential in the application of hemodynamic flow sensing and monitoring the effects on blood flow caused by prosthetic valve implantation via the transcatheter aortic valve replacement operation. The piezoelectric performance of PVDF films can be influenced by the porosity of the material.
Methods
: In this study, strain tracking was performed on thin film PVDF specimens with various levels of porosity and pore sizes to determine the mechanical properties of the specimens. The mechanical properties were used to model the PVDF material in COMSOL multiphysics software, in which compression test simulations were performed to determine the piezoelectric coefficient
d
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of the PVDF.
Results
: A decline in the elastic modulus was found to be highly inversely correlated with porosity of the specimens and the simulation results show that elastic modulus had a much greater effect on the piezoelectric properties than Poisson’s ratio.
Conclusion
: A combination of experimental and computational techniques was able to characterize and correlate the mechanical properties of PVDF films of varying porosities to their piezoelectric properties.
Recent Advances and Perspective of Photonic Bound States in the Continuum
Authors: Xu Guizhen , Xing Hongyang , Xue Zhanqiang , Lu Dan , Fan Jinying , Fan Junxing , Shum Perry Ping , Cong Longqing
Published: June 2023

Recent advancements in photonic bound states in the continuum (BICs) have opened up exciting new possibilities for the design of optoelectronic devices with improved performance. In this perspective article, we provide an overview of recent progress in photonic BICs based on metamaterials and photonic crystals, focusing on both the underlying physics and their practical applications. The first part of this article introduces 2 different interpretations of BICs, based on far-field interference of multipoles and near-field analysis of topological charges. We then discuss recent research on manipulating the far-field radiation properties of BICs through engineering topological charges. The second part of the article summarizes recent developments in the applications of BICs, including chiral light and vortex beam generation, nonlinear optical frequency conversion, sensors, and nanolasers. Finally, we conclude with a discussion of the potential of photonic BICs to advance terahertz applications in areas such as generation and detection, modulation, sensing, and isolation. We believe that continued research in this area will lead to exciting new advancements in optoelectronics, particularly in the field of terahertz devices.
Effectiveness of Flipped Classroom in Learning Social Science
Authors:   Assistant Professor of Education, St. Ignatius College of Education, Palayamkottai, Tirunelveli, Arul Suganthi Agnes L.
Published: June 2023

The purpose of the study was to find out the effectiveness of flipped classroom in learning social science in Higher Secondary Classes. The experimental method of research was employed to find the effectiveness. The design of this Experimental study wasPre-test Post-test equivalent group design. A sample of 60 III group History students was selected. The flipped classroom video lessons were used in the experimental group and the traditional lecture method was used in the control group. An achievement test was conducted to find the effectiveness of the flipped classroom. The findings revealed that learning through flipped classroom was effective in the attainment of objectives such as knowledge, understanding application and skill development when compared to traditional classroom learning through the lecture method.
Immersive Learning: Unlocking the Future of Education
Authors:   ICSSR Post-Doctoral Fellow, Department of Education (DDE), Alagappa University, Karaikudi, Tamil Nadu, Selvakumar S. , Sivakumar P. ,   Senior Professor & Head, Department of Education (DDE), Alagappa University, Karaikudi, Tamil Nadu
Published: June 2023

Educational technology has experienced significant growth and development in recent years, offering new opportunities for enhancing the learning experience. Education 5.0, a student-centred approach to learning, emphasizes the use of emerging technologies such as virtual reality (VR), augmented reality (AR), and blockchain to create immersive and engaging learning experiences. Immersive learning technology has gained recognition, particularly in response to the disruptions caused by the global pandemic, as it bridges the gap between physical and virtual classrooms and provides dynamic and interactive learning experiences. This article explores the potential of immersive learning technology and its impact on education, highlighting its ability to revolutionize the learning process. By analyzing its benefits, challenges, and prospects, this article delves into how immersive learning reshapes education. The article also examines the components of immersive learning technologies, including virtual reality, augmented reality, and mixed reality, and discusses their potential benefits and challenges. It concludes with a discussion on the importance of immersive learning in education and the need for addressing challenges such as cost, content development, and accessibility to unlock its full potential. Overall, immersive learning holds promise for transforming education by enhancing student engagement, promoting personalized and adaptive learning, fostering collaboration and social interaction, and expanding access to education.
Accounting Information System for Processing Zakat Funds at the North Sumatra National Amil Zakat Agency is Online Based
Authors: Sari Zulita Gustika
Published: June 2023

Zakat institutions are institutions that are in the midst of the public, so they are required to have transparency and accountability. In carrying out its activities as an amil, zakat processing organizations have principles that must be obeyed, including zakat processing organizations must have an accounting system and financial management. Audits, as well as publications. These three principles indicate that zakat fund management organizations must be transparent in carrying out their duties. This study aims to determine and examine the application of zakat accounting and accounting policies used by the national amil zakat agency. Provides an overview of the application of zakat accounting in the academic world. To solve this problem, the most effective solution is made, namely a web-based information system. In developing this application using the waterfall method. For the data flow method using UML (Unified Modeling Language) for data modeling using ERD (Entity Relationship Diagram) to describe the data model. With the development of this web-based information system, it aims to build a personal service process for institutions and facilitate the processing of zakat funds so that information regarding services and distribution is conveyed properly to institutions
Malformaciones congénitas de primera costilla
Authors:   , Koch Roberto
Published: June 2023

Dentro del amplio campo de estudio que ofrecen las malformaciones congénitas, las que corresponden a las costillas y al esqueleto torácico, son relativamente bastante frecuentes y han sido observadas por casi todos los anatomistas. Haciendo una sumaria enumeración de las anomalías que pueden estar presentes, diremos que ellas están en relación con el aumento o disminución del número de costillas, con modificaciones en su forma, variaciones en la articulación vertebral o costal, fusiones y bifurcaciones del cuerpo de la costilla, y modificaciones en su posición dentro del conjunto de la jaula torácica. Dentro de Las malformaciones congénitas costales, los de la primera costilla, que constituyen el motivo de este trabajo, no son raras, a pesar de que la general carencia de conocimientos sobre el tema, así pareciera hacerlo suponer.
Decoding academic integrity policies: A corpus linguistics investigation of AI and other technological threats
Authors: Perkins Mike , Roe Jasper
Published: June 2023

NOTE: THIS PAPER IS NOW PUBLISHED THROUGH HIGHER EDUCATION POLICY https://link.springer.com/article/10.1057/s41307-023-00323-2. THE PRESENT TEXT IS THAT ACCEPTED FOR PUBLICATION. This study provides a corpus analysis of academic integrity policies from Higher Education Institutions (HEIs) worldwide, exploring how they address the emerging issues posed by novel technological threats, such as Automated Paraphrasing Tools (APTs) and Generative-Artificial Intelligence (Gen-AI) tools, such as ChatGPT. The analysis of 142 policies conducted in both November 2022 and May 2023 revealed a significant gap regarding the mention of AI and associated technologies in publicly available academic integrity policies. Despite the growing prevalence of these tools in the six-month period since the release of ChatGPT, no HEIs have produced a revised academic integrity policy. Content analysis of 53 guidance documents produced by HEIs suggests an overall positive perception of Gen-AI tools, with a note of caution. This study suggests a modification to Bretag's (2011) exemplary academic integrity model by introducing "Technological Explicitness”, emphasizing the need to include explicit guidelines about new technologies in academic integrity policies. The results underscore the urgent need for HEIs to revise their academic integrity policies, considering the evolving landscape of AI and its implications for academic integrity. This paper argues for a multifaceted approach to deal with the issues of integrating technology, education, policy reform, and assessment restructuring to navigate these challenges while upholding academic integrity.
المكانة الاجنماعية لعلماء الأندلس في بلاد المغرب الاسلامي في القرنين الخامس والسادس الهجريين
Authors: م. د. إنعام حسين أحمد
Published: June 2023

كان نتيجة طبيعية لما حدث في ديار الأندلس من تمزق سياسي وتشرذم وفوضى

عارمة ؛ أن عزم أهل الأندلس ؛ وعلى مختلف طبقاتهم للتوجه لبلاد المغرب الإسلامي ©

وذلك لقربه أولاً وللروابط السياسية والحضارية والثقافية بين البلدين ثانياً.

 

ولربما صنارة نافعة كما يقال ؛ فقد حمل هؤلاء الأندلسيون تراثهم الفكري

والحضاري لتلك البلاد التي استفادت من هذا الإرث وأصبحت تفتخر به على مر الأيام

والأزمنة .

 

وكان لتوجهم أثره في الجانب الاجتماعي ؛ وذلك لكون العلماء يستقرون على

الأرض ويعيشون بين طبقات المجتمع فيبدأ الأثر والتأثر بين الطرفين . ومن هنا جاء

البحث ليسلط الضوء على بعض هذه الجوانب التي ارتأينا فيه تقسيمه الى فقرات وهي :

أولاً: الأضرحة والمزارات .

ثانياً : الاحتفالات والأعياد .

ثالثا : الأزياء والملابس .

رابعاً : الحرف والمهن .

 

وكذلك تناولنا الأثر الاجتماعي وما تركه هؤلاء الأندلسيون الوافدون لأرض

المغرب .

 

وقد اعتمدنا فيه مصادر ومراجع تناولت تاريخ المغرب والأندلس منها كتب

التراجم بالدرجة الأساس ؛ ثم كتب التاريخ العام التي تناولت جهود هؤلاء العلماء وما

أثروه في تلك البلاد .
SISTEM INFORMASI PERSEDIAAN PRODUK MAKANAN RINGAN BERBASIS WEB
Authors: Tucunan Hans Daniel William , Heryana Nono
Published: June 2023

D’Caruluk merupakan perusahaan penjualan makanan ringan yang berlokasi di daerah Bogor. Pada kali ini penulis menganalisis sistem persediaan barang yang D’Caruluk jalankan saat ini. Sistem persediaan produk makanan ringan yang belum terkomputerisasi, pencatatan bukti transaksi untuk penerimaan barang dan pengeluaran barang yang masih tercampur, mengakibatkan sering terjadinya kehilangan dan kerusakan barang. Metode yang digunakan adalah waterfall. Sistem yang dibangun memanfaatkan PHP sebagai bahasa pemrograman dan MySQL sebagai database dalam pembentukan sistem informasi tersebut. Hasil dari penelitian menerangkan bahwa perancangan sistem persediaan barang berbasis web dapat menolong pihak D’Caruluk dalam mendapatkan informasi terhadap transaksi barang dan laporan persediaan barang. Langkah terakhir adalah menguji aplikasi tersebut.
MWMOTE DALAM MENGATASI KETIDAKSEIMBANGAN KELAS PADA PREDIKSI CHURN MENGGUNAKAN KLASIFIKASI C4.5
Authors: Syarif Muhamad , Nugraha Wahyu
Published: June 2023

Churn prediction merupakan salah satu cara untuk memprediksi pelanggan yang berpotensi untuk churn. Metode klasifikasi dapat menjadi salah satu alternatif solusi untuk membuat model churn prediction yang akurat. Karakteristik dari data churn adalah tingkat imbalance yang besar, karena pelanggan yang melakukan churn jauh lebih sedikit dibandingkan pelanggan yang loyal. Perlu melakukan pendekatan pada level data untuk mengatasi imbalance yaitu dengan teknik resampling. Penerapan resampling pada data yang imbalance, maka tingkat imbalance akan semakin kecil dan klasifikasi dapat dilakukan dengan menggunakan metode Oversampling. Metode ini dilakukan dengan menyeimbangkan jumlah distribusi data dengan meningkatkan jumlah data kelas minoritas. MWMOTE (Majority Weighted Minority Oversampling Technique for Imbalanced Data Set Learning) adalah salah satu metode oversampling. MWMOTE terbukti lebih baik dan sebanding dari hasil pengujian menggunakan 24 dataset. Hasil penelitian ini yaitu menghasilkan perbandingan nilai antara penggunaan MWMOTE dan tanpa MWMOTE, hasil perbandingan dapat dilihat pada hasil grafik perbandingan nilai sensitivity, specificity dan AUC. Hasilnya menunjukan peningkatan yang signifikan pada nilai sensitifity dan nilai AUC. Sehingga metode MWMOTE membuktikan menghasilkan nilai yang lebih baik pada penggujian yang menerapkan algoritma klasifikasi C4.5 dataset churn prediction.
PENERAPAN METODE REGRESI LINIER DALAM PERANCANGAN APLIKASI PREDIKSI JUMLAH CALON PESERTA DIDIK BARU BERBASIS WEBSITE
Authors: Misbachul Munir Muhammat , Agus Pranoto Yosep , Adi Wibowo Suryo
Published: June 2023

Man 2 Kota Malang merupakan salah satu sekolah Madrasah Negerei terkemuka di Kota Malang dengan pilihan peminatan yang beragam. Dilihat dari jumlah calon peserta didik baru yang mendaftar di sekolah Man 2 Kota Malang mempunyai minat yang besar setiap tahunnya karena sekolah Man 2 Kota Malang merupakan salah satu sekolah favorit di Jawa Timur. Hal ini tentunya dibutuhkan suatu sistem peramalan untuk memprediksi jumlah calon peserta didik baru dengan tujuan untuk membantu panitia madrasah dalam memetakan kebutuhan pada kegiatan Pendaftaran Peserta Didik Baru (PPDB) di Man 2 Kota Malang, karena saat ini di Man 2 Kota Malang belum ada sistem jumlah calon peserta didik baru yang berdampak belum bisa memprediksi jumlah pendaftar PPDB di tahun berikutnya, sehingga panitia belum bisa memetakan kebutuhan pelaksanaan kegiatan PPDB di tahun berikutnya secara efisien seperti jumlah verifikator berkas pendaftar, jumlah IT helpdesk dan jumlah validator pembayaran dengan pembagian menyesuaikan jumlah pendaftar PPDB agar proses dan pelayanan berjalan dengan cepat dan lancar, maka dari itu penulis membuat suatu sistem prediksi menggunakan metode Regresi Linier. Sistem ini berbasis website, dengan menggunakan database Mysql, bahasa pemrograman yang digunakan adalah PHP dengan framework codeigniter dan bootsrtap. Data yang diolah menggunakan data yang bersumber dari data jumlah pendaftar dari tahun 2019-2022. Parameter yang digunakan adalah periode, jumlah pendaftar, jurusan dan jalur masuk.