bluuebunny/crossref_metadata_2025 huggingface dataset:
The Importance of Knowledge, Skill, Attitude and Competence to Achieve Professional Performance
Authors: Etik Elive Twi , Setiyono Wisnu Panggah
Published: February 2022

This study aims to analyze the effect of knowledge, skills, attitude and competence on professional performance in ASN at the Morokrembangan Kodiklatal Surabaya. The research was conducted using a quantitative approach, with a total sample of 193 ASN in Morokrembangan Kodiklatal Surabaya. The analysis technique used is multiple linear regression analysis, with the help of the SPSS version 25 program. The results show that, 1) knowledge has a significant effect on professional performance, 2) skill has a significant effect on professional performance, 3) attitude has a significant effect on performance. professionals, 4) competence has a significant effect on professional performance, and 5) knowledge, skills, attitudes and competencies on professional performance in ASN at the Morokrembangan Kodiklatal Surabaya.
Analysis of Optimal Portfolio Formation Using a Single Index Model on KLCI Malaysia Stocks for the 2017-2019 Period
Authors: Faqih Abdillah , Hariyanto Wiwit
Published: February 2022

The purpose of this study is to determine the portfolio determination of the Single Index Model, the Random Method, and to find out how the differences between the optimal portfolio returns of the two are. The sample in this study uses purposive sampling, namely the selection of samples with certain characteristics, so as to get 29 stocks in the KLCI index. The technique of data analysis and hypothesis testing uses the Wilcoxon Rank Sum-Test, to find out whether there is a difference in the average of two paired samples, the samples are the same sample. To test the hypothesis using the IBM SPSS Statistics 25 program tool. The results of the research from SPSS output show that the Asym Sig. (2-tailed) is 0.021 where the basis for making the decision is if the significance value (Sig < 0.005 means Ha is accepted). It can be concluded that there is a difference in portfolio returns between using the Single Index Model and the Random Method.
The Effect of Misuse of Information Technology and Student Integrity on Academic Fraud Behavior of Students as Prospective Accountants
Authors: Maharani Novita , Rahmawati Imelda Dian
Published: February 2022

The purpose of this study was to determine (1) the effect of misuse of information technology on the academic cheating behavior of accounting students as prospective accountants, (2) the effect of student integrity on the academic cheating behavior of accounting students as prospective accountants and (3) the effect of misuse of information technology and student integrity on academic cheating behavior of accounting students as prospective accountants at Muhammadiyah University of Sidoarjo accounting students. In data analysis using tabulation of data obtained from the distribution of questionnaires, from the total number of questionnaires distributed of 100 copies, only 80 were returned and could be processed. The analytical tool used to help manage the data is SPSS software version 18.0. The analytical test used is in the form of normality, validity, and reliability tests. Hypothesis testing was carried out using data analysis tests, namely partial tests and multiple linear regression. The results obtained based on the normality test stated that all data were normal, the results of the validity test of all items in the questionnaire were declared valid because rcount > rtable, all reliability test results were declared reliable. Based on the results of the t test, it can be stated that the misuse of information technology (X1), student integrity (X2), has an effect on (Y) accounting student fraud.
The Effect of Good Corporate Governance on Company Value with Financial Performance as an Intervening Variable in State-Owned Companies Listed on the Indonesia Stock Exchange 2016-2018
Authors: Nurhidayah Nikmah , Maryanti Eny
Published: February 2022

The purpose of this study is to prove and analyze the effect of good corporate governance as measured by three indicators, namely independent commissioners. the board of directors and the audit committee on the value of the company through financial performance. This study uses state-owned companies listed on the Indonesia Stock Exchange in 2016-2018 as the population with a total number of 60 companies. The sample was selected using purposive sampling method. This study used a quantitative approach and the research data was tested using Partial Least Square (PLS) data processing. From the calculation results, it is concluded that independent commissioners and audit committees have an influence on firm value. Meanwhile, the board of directors has no influence on firm value. Other results show that independent commissioners and audit committees have no effect on firm value through financial performance. While the board of directors affects the value of the company through financial performance.
Payroll Accounting System Evaluation
Authors: Putri Rosalina Dwi Rahmayanti Diana , Widodo Heri
Published: February 2022

This study aims to determine the accounting system for the study that is applied in the process of running PR. Putra Maju Jaya, located in Tanggulangin, Sidoarjo. In this study, using a qualitative and descriptive approach to analyze and research the payroll accounting system in PR. Son Forward Jaya. Payroll accounting system is an accounting system that regulates the payroll process in a company or agency. The payroll accounting system that is running already meets the existing standards in the running process and is easier and simpler because it uses a computer-based system.
The Role of Green Accounting in Efforts to Prevent Environmental Pollution to Support Business Continuity
Authors: Ilham Ivanda , Widodo Heri
Published: February 2022

This study aims to describe and explain the application of green accounting in helping business continuity at PT Petrokimia Gresik. This research is based on the fact that most companies are still less concerned about environmental pollution problems and only prioritize profits without paying attention to their surroundings and stakeholders. This research method uses qualitative, data collection is carried out by in-depth interviews, documentation of company reports or files that are directly related to environmental costs, then the last is observation. This is done by observing the state of the company to be studied. The data analysis method used interpretive analysis with testing the validity of the data (triangulation) and theory. The results of this study indicate that PT Petrokimia Gresik is still at a level that is not optimal in implementing the application of environmental costs (green accounting) in terms of identifying, recognizing, measuring and disclosing environmental costs for waste management. The company incurs costs regarding environmental conservation, but the company's treatment of these costs is still included in the factory overhead costs. Environmental costs must be reported separately, in the sense of being categorized alone rather than combining them with other costs. The company is still grouping it with other costs so that the environmental costs do not appear in the financial statements. As a result, the environmental costs are hidden.
The Effect of Financial Literacy, Minimum Investment Capital and Investment Motivation on Students' Interest to Invest in the Capital Market with an Understanding of Investment as a Moderating Variable
Authors: Khansa Aisyah Sayyidah , Hariyanto Wiwit
Published: February 2022

This study aims to determine the effect of moderating variables on Understanding Investment in Financial Literacy, Minimum Investment Capital and Investment Motivation on Student Interest to Invest in the Capital Market. The sample in this study was 100 respondents by distributing 100 questionnaires to Accounting Students, UMSIDA. By using data analysis techniques in the form of Outer Model for testing the validity and reliability of the data and Inner Model for hypothesis testing, using the SmartPLS version 3.0 application. The results in this study prove that Financial Literacy and Minimum Investment Capital cannot be moderated by Investment Understanding on Student Interest to Invest in the Capital Market. This is different from Investment Motivation which can be moderated by Investment Understanding. So that it can strengthen the relationship between Investment Motivation and Student Interest to Invest in the Capital Market.
The Effect of Job Stress, Compensation and Job Satisfaction on Turnover Intention through Organizational Commitment as an Intervening Variable for Employees
Authors: Wahyuni Arum Tri , Hariasih Misti
Published: February 2022

This study aims to examine the effect of work stress, compensation and job satisfaction on turnover intention through organizational commitment as an intervening variable. This study uses the approach used in this study is a quantitative approach. The population in this study were 100 employees. The sampling technique used the total sampling technique method (saturated sample). The sample in this study were 100 employees at PT. Jico Agung Sidoarjo. The data used in this study are questionnaire data and data sourced from PT. Jico Agung Sidoarjo. Data collection techniques using questionnaires and observation. Data analysis using smartPLS 3.2.8 Software. The results obtained from this path analysis are obtained from the results that work stress has no significant effect on turnover intention, compensation has a significant effect on turnover intention, job satisfaction has a significant effect on turnover intention, work stress has a significant effect on organizational commitment, compensation has a significant effect on organizational commitment. , job satisfaction has a significant effect on organizational commitment, organizational commitment has a significant effect on turnover intention, job stress has a significant effect on turnover intention through organizational commitment as an intervening variable, compensation has a significant effect on turnover intention through organizational commitment as an intervening variable, job satisfaction has a significant effect on turnover intention through organizational commitment as an intervening variable.
Application of Accounting Information Systems at Zakat, Infaq, Sadaqah Institutions in an Effort to Improve Internal Control on Cash Receipts
Authors: Hanifa Miftachul , Abidin Fityan Izza Noor
Published: February 2022

This study aims to determine the application of accounting information systems at zakat, infaq, shadaqah institutions in an effort to improve internal control on cash receipts at LAZISMU Sidoarjo. This research approach uses a qualitative approach with primary data sources. Data collection was obtained from the results of interviews, observations and documentation. Technical validity of data with triangulation model. The results of the study stated that the application of the accounting information system at LAZISMU, Sidoarjo Regency had used a system from the center, namely the ZISKA software which stands for (Zakat, Infaq, Shadaqah, and Humanity). The advantages of the system are more detailed. However, there are obstacles that occur such as network disturbances and to prevent the risk of data loss, data backup is carried out. To anticipate errors in recording cash receipts, cross checks and evaluations are carried out through meetings. The use of the form or document has been serially numbered printed. Transparent financial reports to the public. Cash deposits to the bank are made every day and are directly deposited on bank business days. In the element of internal control, several weaknesses were found.
Evaluation of the Implementation of Tax Planning as an Effort to Minimize the Tax Burden in the Context of Tax Management
Authors: Agustin Ida , Ernandi Herman
Published: February 2022

This study aims to analyze the evaluation of the implementation of tax planning as an effort to minimize the tax burden in the context of tax management at Pt Supreme Surabaya Motor Service. The sampling method used is qualitative research and is included in descriptive analysis research. research location at PT Supreme Surabaya Motor Service. The data collection that was carried out were interviews, documentation, and observations. Test the validity of the data carried out in this study by using the Triangulation Test. Activities in data analysis in this study are data collection, data reduction, data display, and conclusion drawing/verification. The results of this study indicate that based on the results of the study it can be seen that the tax planning strategy that has been applied by PT. Supreme Surabaya Motor Service with positive and negative corrections to accounts that are not recognized by tax either as income or as an expense resulted in reduced taxable income and the decrease in income caused income tax payable to also decrease. The results of research on optimizing tax planning conducted by PT. Supreme Surabaya Motor Service in terms of taxation can generate tax savings of Rp. 4,561,625,168 and the profit obtained by the company after deducting income tax is Rp. 62,671,215,713.
An Integrated Quality Education Management in the Perspective of the Qur’an Qs. As- Syu’ara’ Verses 181-183 in Tafsir Al-Misbah
Authors: Assa'idi Sa'dullah , Muchtar Azizil , Mashudi Mashudi
Published: February 2022

This research was aimed at revealing and understanding the principle of customer satisfaction of the integrated quality education management  in the Qur’an QS As-Syu’ara’ Verses 181-183, and the implication of the integrated quality education management.  This study used content analysis where qualitative approach was employed. Integrated quality management on education was analyzed its component by consulting the messages and guides in the Qur’an QS As-Syuara’ Verses 181-183 interpreted in the tafseer Almisbach authorized by Indonesian Islamic scholar Prof. Dr. Quraish Shihab.  Results show that quality management in education root on the Islamic teaching that to practice a continued improvement in the entire life.  The quality appears as a daily worship that should improve day by day.  Al Misbach provides guidance and enlightens that education management  is complete measure. Accordingly, you don’t become  one of the members of the groups of people who hurts oneself because of harming others, but weigh for yourself and for others using an accurate scale, don’t hurt others concerning their rights by reducing the quality or the value of something, and don’t make the evil on earth by becoming destroyers in any form after repair is made by Allah or also by human beings. If you give something to humans, thus perfect  the scale and don’t you reduce the weight by giving them  less than it should be.
Examining Teaching Materials in Higher Education Against Religious Intolerance and Pluralism in the Global Era: Islamic Perspective
Authors: Jamilah Sitti
Published: February 2022

This study aims to investigate the role of the study of teaching materials in universities on religious intolerance and pluralism. The study also explores the Islamic perspective on these two dimensions. The location of the research was carried out at the IAIN Parepare of South Sulawesi Province, Indonesia. The source of research data is secondary data obtained from document review of teaching materials in the Aqidah Akhlak (moral theology) course as well as literature relevant to the research topic. The literature study research methodology guided by content analysis focuses on three topics, namely teaching materials, religious intolerance, and pluralism in the view of Islam. The study revealed two findings. First, the results of a study of the components or the appropriateness of the contents of the items of teaching materials in accordance with the values ​​of tolerance as contained in Pancasila and Bhineka Tunggal Ika. Thus, these teaching materials contribute to preventing religious intolerance and provide a new perspective on pluralism. Second, in the view of Islam, it is known that religious intolerance can be avoided by tasamuh, namely by instilling a commendable moral attitude. While pluralism there are two opposing schools between those who accept and reject. In the Qur'an, there is an explanation of pluralism as a necessity, human diversity in togetherness. The conclusion is that the study of teaching materials contributes to supporting tasamuh behavior and avoiding negative views about pluralism. Pluralism is not recommended, namely religious pluralism which is feared to have a negative impact on aqidah. With the study of teaching materials, negative possibilities can be minimized as long as they are in accordance with practice. Because after all, the values ​​of pluralism are also able to foster mutual respect and appreciation between fellow human beings so that they can support the development of student morality. The expected implication is that universities must supervise and provide input on teaching materials that have the potential for the concepts of tolerance and pluralism. The government needs to support the socialization of the true importance of tolerance and pluralism in the campus environment.
A Critical Study of Al-Farabi Philosophy Implementation at Education non Islamic Higher Education in Indonesia
Authors: Asmuni Ahmad
Published: February 2022

The purpose of this study is to conduct a critical study of Alfarabi's philosophy in the implementation of education at Islamic universities in Indonesia. The research method used is a literature study using a philosophical approach. The main data sources are secondary data in the form of Alfarabi's work entitled Risalah fi al-'Aql and previous research works that reveal the philosophical thoughts of Islamic education put forward by Alfarabi. The findings reveal that the Alfarabi philosophy is implemented in the practice of education at Islamic universities in Indonesia through the scope, objectives, and benefits of education. First, the scope of education taught is about the concept of reason (intelligence). Second, the purpose of education is to prepare students through the transfer of knowledge and practical skills to obtain the perfection of life as human beings. Third, the benefits of the concept of value through morality development, teaching methods, and learning evaluation. The conclusion of the research is that Afarabi's philosophy in implementing education in higher education is very important for students and lecturers to improve self-competence. The expected implication is that Islamic Universities not only focus on information and communication technology, but also implement the values ​​of an Islamic philosophy of life in accordance with the guidelines of the Qur'an and al-Hadith.
Making Market Systems Work for Women Farmers in Zambia: A final evaluation of Oxfam's Gendered Enterprise and Markets programme in the Copperbelt region of Zambia
Authors: Morgan Miranda , Stewart Alastair , Lombardini Simone
Published: February 2022

Gendered Enterprise and Markets (GEM) is Oxfam GB’s approach to market systems development. The GEM approach facilitates change in market systems and social norms, with the aim of ensuring more sustainable livelihood opportunities for marginalized women and men. The GEM DFID AidMatch Programme (June 2014–February 2018) worked within the soya, milk and vegetable value chains targeting women smallholder farmers in areas of poverty. The programme aimed to benefit 63,600 people (10,600 smallholder households) living in Zambia, Tajikistan and Bangladesh through increases in household income, women having greater influence over key livelihood decisions within their households and communities, and engaging in livelihoods more resilient to shocks, such as natural disasters and market volatility. In Zambia, the GEM programme has been implemented in four districts of the Copperbelt Province in coordination with implementing partners Heifer Programmes International and the Sustainable Agricultural Programme (SAP). The GEM programme in the Copperbelt seeks to directly improve the livelihoods of an estimated 4,000 smallholder farmers (75 percent women) in the dairy and soya value chains through improved production skills, resilience to climate risks, access to market opportunities, greater engagement with market players and strengthened ability to influence private sector and government actors. The evaluation was designed to investigate if and how the GEM programme might have contributed to its intended outcomes – not only in the lives of individual women smallholder farmers targeted by the programme but also to changes in their communities and the larger market system. It also sought to capture any potential unintended outcomes of the programme.
Total, Bioavailable And Free 25-Hydroxyvitamin D Are Associated With The Prognosis Of Patients With Non-Small Cell Lung Cancer
Authors: Peng Si-Min , Yu Na , Che Jun , Xu Jia-Ying , Chen Guo-Chong , Li Da-Peng , Zhang Yu-Song , Qin Li-Qiang
Published: February 2022

Purpose: To analyze the prognostic value of total, bioavailable and free 25-hydroxyvitamin D (25(OH)D) as well as vitamin D-binding protein (VDBP) in NSCLC patients.Methods: We prospectively collected and analyzed data for 395 patients diagnosed with NSCLC between January 2016 and December 2018 in two university-affiliated hospitals. Total and free 25(OH)D and VDBP were measured directly, and bioavailable 25(OH)D was calculated using a validated formula. Their prognostic values were evaluated by Cox proportional hazards model, and hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated.Results: Patients with NSCLC had significantly lower levels of total, bioavailable, and free 25(OH)D and higher VDBP levels in comparison to healthy controls (all P<0.001). In multivariate analyses, higher levels of total, bioavailable, and free 25(OH)D were independently associated better overall survival (OS) and progression-free survival (PFS). For OS, the adjusted HRs were 0.58 (95%CI, 0.40-0.87; P for trend=0.008), 0.45 (95%CI, 0.30-0.67; P for trend<0.001) and 0.49 (95%CI, 0.33-0.73; P for trend<0.001) for the highest versus lowest tertile of total, bioavailable and free 25(OH)D, respectively. The corresponding adjusted HRs for PFS were 0.61 (95%CI, 0.43-0.86; P for trend=0.006), 0.56 (95%CI, 0.40-0.80; P for trend=0.001) and 0.60 (95%CI, 0.42-0.85; P for trend=0.004), respectively. However, VDBP was not associated with either OS or PFS.Conclusion: The current study suggested that total, bioavailable and free 25(OH)D may be reliable prognosis indicators in NSCLC patients, though the optimal 25(OH)D form for NSCLC prognosis remains to be assessed in future studies.
Enhancing post traumatic growth during the COVID-19 lockdown: the roles of nature relatedness and perceived restorativeness
Authors: Zobel Sara Beomonte , Rogier Guyonne , Parolin Laura , Velotti Partrizia
Published: February 2022

Background
Although the negative outcomes related to traumatic events are well documented, people who experience traumatic events is able to manage the consequences in an adaptive way. This study aims to understand if perception of nature relatedness and perceived potential of restorativeness related to own house, explain Post-Traumatic Growth (PTG) in the context of a pandemic.
Methods
Through an online survey, disseminated during the national lockdown, we recruited 308 adults (Mage = 35.31; SD = 13.91; 22.7% males) administering them questionnaires to evaluate post-traumatic stress disorder (PTSD), PTG, perceived restorativeness and nature relatedness.
Results
Controlling for age and gender, we found that different facets of PTG were differently predicted by PTSD, Nature relatedness and perceived restorativeness. PTSD significantly predicted all dimension of PTG.
Conclusions
Perceived connection to nature as well as the sensation that own house is a place where one can escape from daily routine significantly predicted spiritual change and awareness of new possibilities in own life. Finally, fascination for the place where the individual lived significantly predicted spiritual change.
Implementing a complex hospital innovation: Conceptual underpinnings, program design and implementation of a Complex Innovation in an International Multi-Site Hospital Trial
Authors: Dryden-Palmer Karen , Berta Whitney B. , Parshuram Christopher S.
Published: February 2022

Background: Designing implementation programs that effectively integrate complex healthcare innovations is a fundamental aspect of knowledge translation. Good implementation design requires an active process. We describe a conceptually-grounded framework for the design of implementation programs for complex healthcare innovations and describe its implementation in pediatric hospital settings. Methods: We articulate the grounding implementation model and define overarching goals and principles of the implementation program design. Our Phased Reciprocal Implementation Synergy Model (PRISM) for implementation informed the articulation of the seven design principles: phased implementation approach, end-user engagement, responsive design, intentional integration with existing team processes, customizable implementation interventions, attendance to social mechanisms of influence, and inclusion of processes that support both learning and unlearning processes. These were then operationalized into implementation program, activities and innovation-specific tools. Results: The evidence informed and context responsive implementation program was applied to a complex, hospital wide implementation. Implementation interventions, education, communication and formative and summative evaluation tools were developed then customized for each participating hospital.Conclusion: Theoretically grounded and locally contexted implementation approaches are feasible for the adoption and integration of complex hospital wide innovations. Attention to the fitting of an innovation to local practices, the setting, organizational culture and end-user preferences can be achieved while maintaining the fidelity of the innovation.
Addressing caveats in current skate fisheries management: a comparative study on the morphometry and life history traits of commercially important skates blonde ray Raja brachyura and thornback ray Raja clavata.
Authors: Thys Kelly Johanna Marie , Lemey Laura , Bogaert Noémi Van
Published: February 2022

European skate fisheries management lacks species-specific measures due to data limitation and issues in species-specific reporting. Given these caveats, detailed information on commercially relevant skate stocks at species level is warranted. The morphometry and life-history parameters of 152 individuals (59 Raja brachyura, and 93 R. clavata) were determined for samples collected by observers within commercial fisheries, and two scientific surveys (December 2020 - August 2021) in the Southern North Sea and Eastern English Channel. The morphometry significantly differed between R. brachyura and R. clavata. Morphometric shape descriptor ratios were considered and proven more succesful in species discrimination than linear morphometric measurements. Length-weight relationships indicated faster growth for R. clavata. Age was assessed by visual inspection of enhanced vertebral centra, allowing derivation of von Bertalanffy growth parameters. The macroscopic maturity was determined, and the relationship between body size and sexual development was ascertained in maturity ogives following logistic regression. Maturity assessment revealed interspecific and intersexual differences where male R. clavata matured at the smallest size (L50 = 654 mm) and earliest age (A50 = 10.8 yrs) while female R. clavata matured at the largest size (L50 = 839 mm) and latest age (A50 = 11.5 yrs). The morphometry of congeners R. clavata and R. brachyura significantly differs, which is reflected in the life history traits: length-weight relationships, growth, and reproductive biology. These interspecific differences once again highlight the need for species-specific data collection and management considerations of commercially relevant skate stocks in the Northeast Atlantic Region.
Lessons Learned From a Failed Implementation: Effective Communication with Patients in Transmission-Based Precautions
Authors: Juskevicius Luize Fábrega , Luz Reginaldo Adalberto , Felix Adriana Maria da Silva , Timmons Stephen , Padoveze Maria Clara
Published: February 2022

Background
Patient education and engagement about standard and transmission-based precautions can be one important strategy to prevent adverse events related to isolation. However, most patient education is still highly prescriptive, and is thus unlikely to help patients to engage in their own care. Implementing effective communication between health workers and patients requires behavior change, leading to a meaningful dialogue between the parties involved in the education process.
Objective
this study aimed to evaluate the process of implementation of a protocol for effective communication with patients in transmission-based precautions (Com-Efe).
Methods
This is implementation researchusing qualitative methods, carried out in four sequential phases: 1) non-participant observation in inpatient wards, with the objective of assessing the context; 2) designing the intervention for the implementation of the protocol Com-Efe, based on the results obtained in the previous phase; 3) preliminary assessment and adaptation of the Com-Efe protocol, through workshops with nurses; 4) final assessment of the implementation results, through semi-structured interviews with nurses. The study was performed in a public, secondary level, teaching hospital. The Consolidated Framework for Implementation Research (CFIR) was used as the reference for both interview design and data analysis, aiming to identify barriers and enablers of the implementation process.
Results
The main factors that could have facilitated adherence were beliefs and perceived advantages in using the Com-Efe. The main barriers which may have contributed to the failure of implementation were the unfavorable climate for implementation, insufficient individual and leadership commitment, and lack of understanding of the concepts underpinning effective communication. The participants recognized they had low adherence to the Com-Efe protocol.
Conclusions
Despite using a systematic approach, the Com-Efe protocol was not fully implemented. The lessons learned in this study allowed us to propose suggestions for future implementations in similar contexts. Among these suggestions are to develop strategies to generate awareness of patient-centered care, maintaining patient autonomy, and seeking dialog for patient engagement.
Establishing The Taxa With Phylogenetic Profile And In-Silico-Ayurvedic Remedy Of Microbiome Of Bacterial Vaginosis
Authors: Bagchi Preenon , S Geethashree , IA Shylesh Murthy
Published: February 2022

Bacterial vaginosis (BV) is a vaginal disease commonly caused by bacteria which most commonly causes abnormal vaginal discharge during women’s reproductive-age. BV is characterized by a shift within the vaginal flora from the dominant Lactobacillus to a polymicrobial flora and is further characterized by depletion of the resident lactic-acid-producing Lactobacillus spp. BV has been associated with serious health issues, including pelvic inflammatory disease and increased susceptibility to sexually transmitted diseases (STD) but itself is not a STD. Several genes and chromosomal regions have been found to be associated with BV in various linkage analyses, case-control studies, genome-wide association studies (GWAS), and admixture mapping studies.In this work, using BV microbiome we perform metagenome analysis which enables us to understand how the microbiome responds to the host by studying the functional analysis of genes expressed. The technology is used to determine the order of nucleotides or targeted regions of DNA or RNA. Krona pie chart is used for visualization of the taxonomy. HUMAnN2 tool is used to determine the pathways and their abundance file of microbiome. Further, homology modelling of the BV gene receptors, Leucine Aminopeptidase 3 (LAP3) and Peptidase D (PEPD) was done and ligands from ayurvedic medicinal herbs were established
Errors In Pediatric Death Certificates Issued By Emergency Departments
Authors: Park Byeong Ju , Kim Sun Hyu
Published: February 2022

Background: Errors in pediatric death certificates (DCs) are rarely reported. We analyzed the errors in the pediatric DC issued by an emergency department (ED).Methods: The DCs issued at the ED to patients below the age of 18 years were retrospectively analyzed. Major and minor errors in the DC were investigated based on the WHO International Statistical Classification of Diseases and Related Health Problems (ICD-10) guidelines and evaluated based on the review of the medical records by four emergency physicians. Manner of death was classified into disease (disease group) and external causes (external group) and that two groups were compared. Results: Among the 87 cases of DCs issued by the ED, 98% of errors were confirmed in the disease group and 100% in the external group. The total number of errors in the analyzed DC was 2.3 in the disease group and 3.3 in the external group. Blank space in the cause of death (COD) or duplicated COD (18%) were most common major error in the disease group and two or more causes in a single line of COD (36%) in the external group. Among minor errors, the cases without a time interval record for the COD were the most common in 37 cases (93%) and 42 cases (89%) of the two groups, respectively.Conclusion: One or more errors were identified in 99% of pediatric DCs issued by ED, and the total number of errors was higher in the external group than in the disease group.Trial registration: none
Anti-SARS-Cov-2 Iga And Igg In Human Milk From Vaccinated Mothers After Holder Pasteurization.
Authors: Selma-Royo Marta , Gormaz María , Bäuerl Christine , Ramón-Beltrán Amparo , Cernada Maria , Esteban Maria Jesús Vayá , Martinez-Rodriguez Laura , Vento Máximo , Parra-Llorca Anna
Published: February 2022

Breastfeeding rendered crucial for preterm infants during COVID-19 pandemic. However, the role of donated human milk (DHM) in the protection against SARS-CoV-2 infection when own mother’s milk is not available or insufficient remains unclear. Pasteurization of DHM contributes to the loss of some biological and nutritional properties of human milk. The presence of specific breast milk SARS-CoV-2 antibodies has been demonstrated in women after COVID-19 disease and after vaccination. We aimed to evaluate the impact of Holder pasteurization on vaccinated donor women’s milk and to identify the impact on the concentrations of specific immunoglobulins (Ig) against SARS-CoV-2. A prospective, observational, exploratory pilot study in lactating women (n=12) who received the complete course of mRNA-based vaccines (BioNTech/Pfizer) against SARS-CoV-2 infection was conducted. Levels of antibodies directed to structural receptor-binding domain of the SARS-CoV-2 spike protein were determined by ELISA before and after pasteurization.IgA and IgG anti-SARS-CoV-2 immunoglobulin concentrations were significantly reduced after Holder pasteurization. Interestingly, there was a negative correlation between the initial amount of anti-SARS-CoV-2 antibodies and the percentage of their recovery after the pasteurization for both isotypes. Despite the partial loss of immunoglobulins still a high percentage of antibodies remained after the pasteurization, a mean of 70.53 (3.4)% of anti-SARS-CoV-2 IgA and 81.99 (21.89)% of IgG antibodies. Our study underscores the potential relevance of breast feeding or alternatively DHM to provide babies at risk with virus-specific SARS-CoV-2 antibodies thus protecting them against COVID-19.
Retinal Ganglion Cell Layer Thickness And Volume Measured By Optical Coherence Tomography Changes With Age, Sex, And Axial Length In A Healthy Population
Authors: Al-Hawasi Abbas , Lagali Neil
Published: February 2022

Background: The GCL measurements with OCT are important for both ophthalmologists and neurologist because of the association with many ophthalmic and neurological diseases. Different factors can affect these measurements, as brain pathologies, ocular AL as well as age and sex. Studies that conducted to measure GCL have overlooked many of these factors. The purpose of this study is to examine the effect of age, sex, and axial length on normal retinal GCL thickness and volume in a healthy population without any neurological diseases.Methods: A prospective cross-sectional study to measure the retinal (GCL) thickness and total volume with optical coherence tomography (OCT) with automated segmentation and manual correction where needed. Visual acuity, axial length, and autorefraction were also measured. A mixed linear model was used to determine the association of the effect of the various parameters on the GCL thickness and volume.Results: 116 eyes of 60 subjects (12-76 years of age, 55% female) were examined of which 77% had 0 ± 2 D of spherical equivalent, and mean axial length was 23.86 mm. About 25% of the OCT-automated GCL measurements required manual correction. GCL thickness did not differ in similar anatomic regions in right and left eyes (P > 0.05). GCL volume was greater in males relative to females after adjustment for age and axial length (1.13 ± 0.07 mm3 for male vs 1.09 ± 0.09 mm3 for females; P = 0.031). GCL thickness differed between males and females in the inner retinal ring (P=0.025) but not in the outer ring (P=0.66). GCL volume declined with age (P=0.031) but not after adjustment for sex and axial length (P=0.138). GCL volume declined with longer axial length after adjustment for age and sex (P=0.048). Conclusion: Age, sex and axial length should be taken into consideration when measuring the GCL thickness and volume with OCT. Automated OCT segmentation should be reviewed for manual adjustments.
Correlated Expression of The Body, Face, and Voice During Character Portrayal in Actors
Authors: Berry Matthew , Lewin Sarah , Brown Steven
Published: February 2022

Actors are required to engage in multimodal modulations of their body, face, and voice in order to create a holistic portrayal of a character during performance. We present here the first trimodal analysis of the process of character portrayal in professional actors. The actors portrayed a series of stock characters (e.g., king, bully) that were organized according to a predictive scheme based on the two orthogonal personality dimensions of assertiveness and cooperativeness. We used 3D motion capture technology to analyze the relative expansion/contraction of 6 body segments across the head, torso, arms, and hands. We compared this with previous results for these portrayals for 4 segments of facial expression and the vocal parameters of pitch and loudness. The results demonstrated significant cross-modal correlations for character assertiveness (but not cooperativeness), as manifested collectively in a straightening of the head and torso, expansion of the arms and hands, lowering of the jaw, and a rise in vocal pitch and loudness. These results demonstrate what communication theorists refer to as “multichannel reinforcement”. We discuss this reinforcement in light of both acting theories and theories of human communication more generally.
Prevalence of Childhood Cataract and Associated Factors Among a Pediatric Population at A Tertiary Hospital in Ghana
Authors: Amankwaa-Frempong Doreen , Atia Kelvin , Kumah David Ben , Junior Isaiah Osei Duah , Addo Emmanuel Kofi , Ahmed Abdul-Sadik , Akuffo Kwadwo Owusu
Published: February 2022

Background: Childhood cataract unlike adult-related cataract has received a little attention despite the devastating consequences on the early development of the visual system and the overall impact on the quality of life of children. The existence of accurate epidemiological data is a primary step towards management strategies, however, there remains a paucity of data in sub-Saharan Africa including Ghana. Therefore, the study sought to investigate the prevalence of childhood cataract and its associated factors among a pediatric population at a tertiary health facility in Ghana. Methods: The study employed a retrospective electronic medical-record review on 263 pediatric cataract cases examined (from January 2019 to December 2020) at the pediatric ophthalmology department of the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Patient clinical data including sociodemographic, signs and symptoms, primary diagnosis and associated ocular complications were gathered and analyzed using Statistical package and Service Solution (SPSS). Chi-square and regression statistics were used to summarize data at a significance of p< 0.05. Results: The prevalence of childhood cataract was 4.25% (263/6,188). The proportionate distribution of cataracts was congenital (39.5%), traumatic (33.1%) and developmental (26.6%). Over half (51.7%) of the subjects had unilateral cataract. The major complications of childhood cataracts were strabismus (5.70%), nystagmus (3.0%) and retinal detachment (1.90%). Older age (2-12 years, OR = 0.27, p<0.001; > 12 years, OR = 0.12, p<0.001) was significantly associated with reduced odds of congenital cataract. Similarly, increasing age (2-12 years, OR = 12.59, p<0.001; > 12 years, OR = 7.57, p = 0.004) and female sex (OR = 0.58, p = 0.038) was significantly associated with decreased odds of traumatic cataracts. Conversely, older age (2-12 years, OR = 11.02, p<0.001; > 12 years, OR = 26.57, p<0.001) and female sex (OR = 2.27, p = 0.008) were significantly associated with increased odds of developmental cataracts. Conclusion: Our results suggest a higher burden of childhood cataract (approximately four in every hundred children had childhood cataract). This evidence warrants the implementation of pre-school vision screening and eye health education programmes to promote early detection and prevention of avoidable vision impairment and/or blindness within the pediatric population.
Factors influencing parental decisions to terminate pregnancies following prenatal diagnoses of major fetal anomalies at a single university hospital in Thailand
Authors: Pusayapaibul Papapin , Manonai Jittima , Tangshewinsirikul Chayada
Published: February 2022

Background: The rate of termination of pregnancy (TOP) for fetal anomalies and the factors affecting TOP vary among different populations. Optimisation of prenatal care and counselling requires understanding the factors influencing parental decisions in the relevant population. This study aimed to evaluate the rate of TOP after diagnoses of major fetal anomalies and assess factors associated with TOP-related decisions at a university hospital in Thailand.Methods: A retrospective chart review was conducted at the Fetal Anomaly Clinic of the university hospital in Thailand. Medical records of all women with singleton pregnancies prenatally diagnosed with major fetal anomalies before 24 gestational weeks between 2010 and 2020 were reviewed.Results: During the study period, 461 cases of major fetal anomalies were diagnosed, and 264 (57.3%) of these pregnancies were terminated. Three factors influencing parental TOP decisions were lethal anomalies (odds ratio [OR], 177.41; 95% confidence interval [CI], 46.97–670.15; p <0.001), presence of genetic abnormalities (OR, 11.93; 95% CI, 4.93–28.91; p <0.001) and an early gestational age of <20 weeks (OR, 3.81; 95% CI, 2.01–7.22; p <0.001).Conclusions: Over half of the pregnant women whose records were reviewed and who were prenatally diagnosed with major fetal anomalies terminated their pregnancies. Fetal factors, particularly lethality, genetic abnormalities and early gestational age at diagnosis, showed the most powerful associations with parental TOP decisions. Other maternal background factors were not key considerations.
The Retrospective Evaluation Of Endocrine Manifestations In Chinese Patients With Wilson’s Disease
Authors: Zhang Mei-Yan , Zheng Zi-Wei , Shi Zhi-Feng , Xu Meng-Hui , Wang Rou-Min , Xu Wan-Qing , Wu Zhi-Ying , Dong Yi
Published: February 2022

Purpose: The endocrine manifestations of Wilson’s disease (WD) tended to be ignored, especially as initial clinical aspects. Currently there was a paucity of studies for endocrine involvement in WD patients. We aim to explore the explicit impact of WD on the endocrine system, to reduce the misdiagnosis.Methods: A retrospective study was performed in 37 female patients with WD. They were recruited from the Second Affiliated Hospital of Zhejiang University School of Medicine from October 2018 to October 2020. Each patient was diagnosed with WD according to clinical evaluation and genetic test. Their menstrual, pregnancy and childbirth history, and sex hormone levels were collected and analyzed.Results: The average age of menarche was 13.7 ± 2.0 years. The proportion of delayed menarche was 37.8%. The patients with irregular menstruation after menarche accounted for 50%. Among 65 conceptions of 37 WD patients, the spontaneous abortion, induced abortion, preterm birth, and full-term delivery rate was 46.2%, 27.7%, 12.3% and 13.8% respectively. The abnormal hormone levels of the 35 cases mainly consisted of 14 cases (40%) with increased PRL, 10 cases with decreased P (28.6%), 8 cases (22.9%) with increased SHBG and 6 cases (17.1%) with increased T.Conclusion: The endocrinologic manifestations among WD patients could be not uncommon. WD patients could manifest as irregular menstruation, recurrent abortion, and even infertility. These minor aspects as a presenting feature of WD are prone to be neglected. Therefore, WD should be encountered in the differential diagnosis of endocrine system dysfunction.
Developing Guidelines On Code Status Conversations With Older Adults Upon Hospital Admission: Results From A Survey Of Experienced Healthcare Professionals
Authors: Sterie Anca-Cristina , Poncin Emmanuelle , Jox Ralf J. , Truchard Eve Rubli , Major Kristof
Published: February 2022

Background: Shared decision-making is the cornerstone of patient-physician communication on life-sustaining therapies, such as cardio-pulmonary resuscitation (CPR). Nevertheless, the application of these standards to everyday medical practice in hospitals is limited. Our objective was to establish clear and comprehensive recommendations for junior physicians in our hospital regarding code status conversations. Methods: Provisional recommendations about CPR discussions between physicians and adult patients upon hospital admission were informed by a rapid review of the literature, and sent to 146 experienced healthcare professionals in French-speaking Switzerland, who were asked to evaluate each recommendation quantitatively and qualitatively, and to provide additional recommendations. Results: Based on a review of 53 articles, we formulated 11 provisional recommendations, which were evaluated by a panel of 39 experienced healthcare professionals. Overall agreement with all submitted recommendations was high (85%). Recommendations pertaining to physicians clarifying patients’ understanding of their medical state and prognosis at the start of the discussion, and approaching CPR in the context of goals of care, striving to clarify the patient’s values, purposes, preferences and expectations, had the greatest approval rate and were considered most important. Disagreement mostly concerned the need to discuss CPR with all patients. Conclusions: Our set of approved recommendations advocate a model of informed, shared decision making that reflect both the medical indication and patients’ life plans. These recommendations will serve as basis for devising a training for resident physicians, and will be adapted for other health professionals.