bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Cut-off Points of the Standardized Continuous Metabolic Syndrome Severity Score (cMetS-S) for Predicting Cardiovascular Disease (CVD) and CVD Mortality in the Tehran Lipid and Glucose Study (TLGS)
Authors: Adib Maryam , Mehran Ladan , Masoumi Safdar , Vatanpoor Iman , Azizi Fereidoun , Amouzegar Atieh
Published: December 2024

Background: Metabolic Syndrome (MetS) is a prevalent condition associated with an increased risk of cardiovascular disease (CVD) and CVD mortality. Due to the limited clinical applicability of MetS, the standardized continuous metabolic syndrome severity score (cMetS-S) has the potential to provide continuous assessment of metabolic risk. Objectives: This study evaluated the optimal cMetS-S cut-off points in the Tehran Lipid and Glucose Study (TLGS) for predicting CVD and CVD mortality. Methods: The study included 7,776 participants over 30 years old at baseline, followed for 18 years. Sex-specific sensitivity (SS) and specificity (SP) of cMetS-S measures for predicting CVD and CVD mortality were evaluated using a receiver operating characteristic (ROC) curve, along with the area under the curve (AUC), employing a naive estimator and considering event failure status and MetS variables. Results: The cut-off point of cMetS-S for CVD was 0.13 (SS: 65.5%, SP: 59.6%) for the total population, 0.44 (SS: 49.6%, SP: 68.1%) for men, and 0.27 (SS: 64.2%, SP: 69.2%) for women. The cut-off point of cMetS-S for CVD mortality was 0.53 (SS: 51.3%, SP: 71.9%) for the total population, 0.76 (SS: 35.1%, SP: 76.2%) for men, and 0.28 (SS: 78.8%, SP: 66.4%) for women. The AUC (95% CI) of MetS based on the International Diabetes Federation (IDF) and Joint Interim Statement (JIS) definitions were 60.0 (65.3 - 56.8) and 61.1 (59.6 - 56.8) for CVD, and 59.3 (56.0 - 62.5) and 59.4 (56.3 - 62.6) for CVD mortality. Conclusions: The cut-off points of cMetS-S for CVD and CVD mortality differ between men and women. The cMetS-S could be a better predictive tool for CVD and CVD mortality than MetS.
Reinforcement Learning Approach to Enhance Grid-Forming Control in Energy Systems
Authors: Zaki Mohammed , Gozde Haluk , Taplamacioglu M. Cengiz , Salor Ozgul , Akbarlı Reyhan
Published: December 2024

Abstract— Integrating renewable energy sources and
transitioning to low-inertia power systems requires innovative
grid stability and resilience solutions. Grid-forming inverters
(GFMs) are crucial in this shift, enabling voltage and
frequency regulation in systems with diminishing synchronous
machine-based inertia. As the complexities in this domain
increase, controlling energy flows using conventional
techniques becomes challenging. This paper reviews
Reinforcement Learning (RL) applications and their
transformative potential in tackling the dynamic complexities
of modern power systems, focusing on virtual synchronous
generator-based grid forming inverters (VSG-GFMI) control.
Implementasi Pendidikan Integratif dalam Pembentukan Karakter Insan Kamil di Pesantren Mahasiswa An Najah Purwokerto
Authors: Lutfiana Annisa , Fauzi Fauzi
Published: December 2024

Integrative education is an approach that combines various disciplines and skills to shape individuals who are balanced intellectually, morally, and socially. This research aims to explore the implementation of integrative education in the character formation of kamil individuals at the An-Najah Student Islamic Boarding School in Purwokerto. The method used in this research is a qualitative approach with techniques such as in-depth interviews, observation, and documentation study. The research sample consists of caregivers, teachers, and students of the An-Najah Student Islamic Boarding School in Purwokerto. The collected data were analyzed using thematic analysis techniques to identify the application of integrative education in the formation of kamil human character. The research results show that the implementation of integrative education at An-Najah Student Islamic Boarding School includes strengthening the aspects of spirituality, religiosity, entrepreneurship, and leadership. In addition, programs such as Quranic studies, leadership training, entrepreneurship, and habituation to interacting with the surrounding community contribute to shaping the character of students who are virtuous, responsible, and ready to contribute to social life. In conclusion, the integrative education implemented at Pesantren Mahasiswa An-Najah Purwokerto has proven effective in shaping the character of a balanced insan kamil, harmonizing intelligence, morality, and social skills.
Optimalisasi Pemanfaatan Tanaman Obat Keluarga (Toga) Oleh Generasi Peduli Melalui Pengabdian KKN Di Desa Bandar Padang
Authors: Darisman Fahrozi , Dhita ketrin febriana shinta  , Fahni Azrun  , Ocha Suriyanti  , Linda Febriani  , Hafifah Tri Kamelty  , Misyuni Anami  , Fahri Irfan  , Nisa Nazara Gunarto  , Ilmi Karina  , R. Vivi Oliviera  , Puthy Geni Trie Andini  , Fatma Dewi  , Risca Aulia
Published: December 2024

Pemanfaatan Tanaman Obat Keluarga (TOGA) sering kali belum optimal di kalangan masyarakat, terutama dalam hal penerapan dan keberlanjutan penggunaan di tingkat rumah tangga. Masalah ini diperparah oleh kurangnya kesadaran dan pengetahuan generasi muda tentang potensi TOGA sebagai solusi kesehatan alami. Penelitian ini bertujuan untuk mengoptimalkan pemanfaatan TOGA melalui kegiatan Kuliah Kerja Nyata (KKN) yang melibatkan Generasi Peduli di Desa Bandar Padang. Metode yang digunakan meliputi penyuluhan, pendampingan, serta praktek langsung dalam penanaman dan pengolahan TOGA. Hasil dari kegiatan ini menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan masyarakat, khususnya generasi muda, dalam memanfaatkan TOGA. Selain itu, terbentuk juga kelompok-kelompok peduli TOGA yang diharapkan mampu menjaga keberlanjutan program ini. Dengan demikian, optimalisasi TOGA tidak hanya mendukung kesehatan masyarakat, tetapi juga memperkuat kemandirian desa dalam hal pemanfaatan sumber daya alam lokal.
Hellp’s Syndrome – Maternal Morbimortality, Clinical Case Report
Authors:   Doctor in Medicine and Surgery. Specialist in Gynecology and Obstetrics. Professor at the National University of Loja, Ecuador, Jirón Karina Yesenia Calva , Berrú Celsa Beatriz Carrión ,   Doctor in Medicine and Surgery, Professor at the National University of Loja, Ecuador., Ruilova Ximena Patricia Carrión ,   Doctor in Medicine and Surgery. Specialist in Gynecology and Obstetrics. Professor at the National University of Loja, Ecuador, Moncada María del Cisne Luzuriaga ,   Pharmaceutical Biochemist Fourth level. Biological analysis and laboratory diagnosis. Professor at the National University of Loja, Ecuador., Calva Camila Alejandra Armijos ,   Medical student at the National University of Loja. Loja, Ecuador.
Published: December 2024

Introduction: HELLP syndrome is a hypertensive disorder of pregnancy associated with severe maternal-fetal complications and representing high morbidity and mortality.
Objective: A clinical history of HELLP syndrome as a complication of severe preeclampsia was analyzed, highlighting the importance of early detection and appropriate treatment.
Clinical case: A young 26-year-old multi-gestation patient from the city of Loja, with a family history of arterial hypertension, was diagnosed with HELLP syndrome and severe preeclampsia in the 33rd week of gestation after five prenatal check-ups and due to the severity of her condition, it was decided to terminate the pregnancy by cesarean section.
Conclusion: The importance and urgency of early identification and treatment of HELLP syndrome and its complications, highlighting the need for an individualized approach based on the patient’s laboratory studies and the importance of management in primary care and the patient’s care.
Cristóbal Méndez y el Ejercicio Físico como pilar de la salud en el siglo XVI
Authors: Díaz Cuéllar Pablo
Published: December 2024

Cristóbal Méndez fue un médico que ejerció su profesión en el siglo XVI, considerado como el precursor de la medicina deportiva. Bajo una época de grandes cambios sociales, culturales, en el ámbito médico y científico; y caracterizada por numerosos conflictos sociales y políticos, publicaría la obra llamada “Libro del Ejercicio Corporal y sus provechos”, mediante la cual haría promoción de la actividad física para prevenir enfermedades y para mantener la salud, y compatibilizarlo con la vida diaria para hacerlo un hábito en la población española. La influencia de figuras grecolatinas ha llegado también a esta obra, como Galeno e Hipócrates, entre otros. Además, esta obra da pie a valorar el estilo de vida sedentario como perjudicial para el bienestar humano, y el que poseían ciertos trabajadores de la época, tales como la Iglesia, que durante la Edad Moderna tuvo control sobre la producción científica y práctica médica del momento.
İnsan Kaynakları Yönetiminde Yeni Trendler: Yetkinlik ve Yetenek Yönetimi
Authors: Kuzgun Şerife
Published: December 2024

Bu çalışma, insan kaynakları yönetiminde stratejik bir önem kazanan yetkinlik ve yetenek yönetimi kavramlarını incelemekte ve bu kavramların işletmelerin sürdürülebilir başarı elde etmesindeki rolünü ele almaktadır. Günümüz iş dünyasında dijitalleşme, çevik yönetim, çeşitlilik ve kapsayıcılık gibi yeni trendlerin etkisiyle, işletmelerin yetenek çekme, geliştirme ve elde tutma süreçlerinde köklü değişiklikler yaşanmaktadır. Bu bağlamda, çalışmada ilk olarak yetkinlik ve yetenek yönetimi kavramlarının teorik çerçevesi sunulmuş, ardından bu yaklaşımların işletmelere sağladığı stratejik avantajlar tartışılmıştır. Ayrıca, Türkiye’deki ve dünyadaki önde gelen işletmelerden uygulama örnekleri verilerek yetenek yönetimi uygulamalarının iş dünyasındaki yansımaları somutlaştırılmıştır. Çalışmanın bulguları, yetenek yönetiminde dijitalleşme ve esnek çalışma modellerinin verimliliği artırdığı, kapsayıcı politikaların ise inovasyonu destekleyerek işletmelere rekabet avantajı sağladığı yönündedir. Bu çalışma, yetkinlik ve yetenek yönetimi üzerine mevcut literatüre katkı sunmayı ve insan kaynakları alanında stratejik karar alma süreçlerine rehberlik etmeyi amaçlamaktadır.
Datengetriebene Modellierung und Merkmalsselektion für die automatische Kalibrierung eines Sensorsystems für die mikromagnetische Materialcharakterisierung
Authors: Wittich Felix , Kroll Andreas
Published: December 2024

Der industrielle Echtzeiteinsatz zerstörungsfreier Prüfverfahren bietet ein großes
Potenzial für die Analyse oberflächennaher Werkstückeigenschaften. Neben einer möglichen Zeit- und Kostenreduktion durch die direkte Integration von Prüfverfahren in den Bearbeitungsprozess, die bisher nur offline durchführbar war, ermöglicht dies eine Überwachung und gezielte Regelung von relevanten Werkstückeigenschaften im laufenden Prozess. Eine zentrale Herausforderung beim Einsatz mikromagnetischer Materialcharakterisierungsverfahren (MMV) [1] ist dabei deren Kalibriermodellerstellung. Die MMV können beispielsweise bei der Prozessdatenerfassung für die Prozessparameteroptimierung in der Fertigung eingesetzt werden [2], ohne dabei aufwendige ex-process Referenzmessungen durchführen zu müssen. In diesem Beitrag wird ein Ansatz für die datengetriebene Kalibriermodellerstellung für die mikromagnetische (MM) Messung vorgestellt und anhand eines Hartdrehdatensatzes untersucht.
Juego de rol interdisciplinar para trabajar la salud emocional de futuros profesionales sanitarios
Authors: Redondo Rodríguez Celia , Rodríguez Velasco Francisco José , Gil Fernández Guadalupe , Becerra Mejías José Alberto
Published: December 2024

El desarrollo de la inteligencia emocional es fundamental para establecer una buena relación interpersonal entre los miembros de un equipo profesional y entre el profesional sanitario y el paciente para un cuidado humanizado, por ello, la presente propuesta de innovación educativa propone una metodología basada en el juego de rol, donde los estudiantes del grado de psicología y enfermería trabajen en grupos interdisciplinares simulando en el contexto académico situaciones difíciles de gestionar del ámbito sanitario. Este trabajo ofrece una guía que facilita el diseño y desarrollo de juegos de rol de carácter interdisciplinar, cuyo objetivo es la adquisición por parte de los estudiantes universitarios de las competencias de los planes docentes involucrados. El uso de una metodología activa y reflexiva en nuestras aulas es una alternativa adecuada, para que el alumnado universitario pueda desarrollar las competencias emocionales y de comunicación necesarias para poder prestar una mejor calidad asistencial.
Profundidad óptica de la vegetación (VOD): revisión de los productos de SMAP y perspectivas para sus aplicaciones agrícolas en el sudeste de la Región Pampeana de Argentina
Authors: Beninato Sabrina , Holzman Mauro Ezequiel , Rivas Raúl Eduardo , Diez Jorge Francisco
Published: December 2024

Las observaciones de microondas en las frecuencias entre los 1-2 GHz (banda L) son sensibles a la humedad de suelo superficial (SM) y al contenido de agua en la vegetación, el cual puede parametrizarse por medio de la profundidad óptica de la vegetación (VOD). El objetivo de este trabajo fue presentar los principios físicos de las mediciones de microondas pasivas y un análisis preliminar sobre las dinámicas hídricas de la vegetación en el sudeste de la Región Pampeana por medio de la observación de las series temporales de VOD y SM de la misión Soil Moisture Active Passive mission (SMAP). Para complementar a estos análisis, se incorporaron observaciones del índice de vegetación de diferencia normalizada (NDVI) y de la temperatura de superficie (LST) obtenidos en campo y derivados de medidas registradas por sensor  Moderate-Resolution Imaging Spectroradiometer (MODIS). Los resultados mostraron que la VOD presenta capacidad para determinar variaciones subsemanales relacionadas al contenido de agua en la vegetación mediante comportamientos acoplados con la SM y la LST bajo condiciones homogéneas de superficie. Particularmente, durante las temporadas de verano se observaron que aumentos localizados de LST coincidieron con bajas de VOD. Estas observaciones demostraron el potencial de VOD tanto para el seguimiento de la dinámica hídrica de la vegetación a escala subsemanal como para la detección de eventos puntuales de estrés hídrico.
psicoterapia psicanalítica do paciente com Parkinson no contexto da clínica ampliada
Authors: Uliana Maithê Cristina , Campos Érico Bruno Viana
Published: December 2024

Considerada uma doença neurológica degenerativa com curso crônico e progressivo, o Parkinson ocasiona perdas e mudanças que são marcadas por um intenso sofrimento psíquico, semelhante ao traumático, que pode levar a uma difícil elaboração dos processos de luto. Este relato de experiência objetivou compreender os aspectos emocionais e inconscientes da reabilitação do paciente com Parkinson. Trata-se de um relato de caso clínico a partir do acompanhamento psicológico a um paciente com Parkinson, em um centro de reabilitação física no noroeste do estado de São Paulo. A coleta de dados ocorreu pelo diário de bordo da psicóloga-pesquisadora de orientação psicanalítica e as interpretações a partir das categorias conceituais dessa teoria. Constatamos aspectos inconscientes que apontam para saídas patológicas, como a inibição depressiva. Destacamos a psicoterapia psicodinâmica breve no contexto da clínica ampliada como um importante espaço de escuta da singularidade e um dispositivo facilitador para o processo de luto.
A Normalização ambiental à luz da transnormatividade: os reflexos dos padrões ISO (International Organization For Standardization) sobre a gestão de Riscos da Nanotecnologia no Brasil
Authors: Cesaro Daniel de , Pereira Reginaldo , Copetti Alex
Published: December 2024

Tecnologias disruptivas, por tornarem obsoletas aquelas que lhes antecedem, têm a capacidade de mudar a forma como vivemos e causam abalos em diversos setores econômicos e formas de vida. Por outro lado, o direito moderno, pautado em processos que atuam ex-post-facto, apresenta sérias dificuldades para acompanhar os riscos e as perplexidades causadas pelo avanço tecnológico. O artigo discute a lentidão e a dificuldade do sistema jurídico brasileiro em regular novas tecnologias, como a nanotecnologia, e como esta inércia pode abrir espaço para a autorregulação. Para delimitar o espaço da normalização no ordenamento jurídico, utiliza-se a teoria da transnormatividade, dada a aptidão para analisar contexto complexos cortados por normatividades internas e externas, públicas e privadas. O artigo problematiza, ainda, a possibilidade de a autorregulação dar vazão à regulamentação de setores econômicos, tais como o da nanotecnologia. A discussão inclui a análise da situação atual da regulação das nanotecnologias no Brasil, com ênfase nas regulações ambientais, e o papel da autorregulação no cenário nacional e internacional, focando na norma internacional ISO/TC 229. O artigo sugere que a autorregulação pode ser uma resposta à inércia dos ordenamentos estatais, buscando uma padronização e regulação a nível internacional que possa ser mais ágil do que a legislação tradicional.
As contribuições da escola positivista no processo de criminalização das crianças e adolescentes: análise dos discursos da escola positivista e seu contributo no estigma da menoridade penal
Authors: Leonardo Amorim Antônio
Published: December 2024

Mesmo depois de dois séculos da Escola Positivista, seus discursos perspassaram séculos, se mantendo vigente em nossa sociedade e até os dias atuais refletem socialmente. Várias são as tentativas de criminalização das crianças e adolescentes no Brasil, todas essas propostas de criminalização das crianças e adolescentes tem como ponto inicial de partida os discursos da Escola Positivista. Não se tem no Brasil nenhum registro de dados que demonstram que piorar a punição do acusado, levará a ausência de cometimento de crimes, pelo contrário, o Brasil tem apostado na criminalização e repressão de condutas, mesmo assim, os dados apresentados pelo Estado dão conta de aumento substancial de crimes e pessoas encarceradas. Essa pesquisa se propõe analisar as contribuições da Escola Positivista na criminalização das crianças, analisando os principais autores da referida escola, em suas obras literárias, dialogando com as tentativas de criminalização das crianças e adolescentes no Brasil do século XXI. A Escola Positivista contribuiu na construção de discursos belicistas contra crianças, em especial quando se afirmou que o ser o indivíduo nasce criminoso, é o que faz Lombroso, um dos principais percussores da Escola Positivista. Compreender historicamente o processo de integração social dos discursos de eliminação de corpos pela Escola Positivista, com as diversas tentativas de criminalização e eliminação das crianças e adolescentes. Diante disso, indaga-se, qual(is) a(s) contribuição(ões) da Escola Positivista no processo de contribuição do estigma da menoridade penal? A resposta a esse problema de pesquisa se dará a partir do método dedutivo, da pesquisa bibliográfica sobre quais foram as contribuições da Escola Positivista na construção do estigma da menoridade penal. Para que a pesquisa seja realizada, será analisado os percursores da Escola Positivista, Ferri, Garofalo e Lombroso.
Traditional Architecture, a Triggering Factor for Rural Tourism Development in Romania
Authors:   Department of Hospitality Services, Faculty of Business, Babeș-Bolyai University, Cluj-Napoca, Romania, Coroș Monica Maria , Balint Cristina Ioana ,   Department of Business, Faculty of Business, Babeș-Bolyai University, Cluj-Napoca, Romania
Published: December 2024

Rural tourism has been identified as one of the most attractive types of tourism among Romania's international visitors. Furthermore, the entire context generated by the COVID-19 pandemic has led to the orientation of Romanian tourists towards remote destinations and small lodgings, located especially in rural destinations. Thus, new opportunities have been identified and capitalized upon by entrepreneurs in the hospitality sector. This paper is a research note that aims to highlight the development of a new niche on the Romanian rural tourism market. Namely, employing desk research methods, this paper focuses on identifying the destinations where new lodgings were developed making use of traditional houses, which were moved and rebuilt there. The main research question can be formulated as follows: Does rural authentic architecture contribute to the development of a qualitative offer of lodging services in rural areas, in line with the expectations of baby boomers and millennials?
Beer as a functional beverage?
Authors: Habschied Kristina , Krstanović Vinko , Mastanjević Krešimir
Published: December 2024

The expansion of the beer industry has enabled many possibilities for improvement regarding the taste, aroma and functionality of this drink. Health-related issues and a general wish for healthier lifestyles has resulted in increased demand for functional beers. The addition of different herbs or adjuncts in wort or beer has been known for centuries. However, today's technologies provide easier ways to do this and offer additional functional properties for the health benefits and sensory adjustments of classical beer. Medicinal, religious or trendy reasons for avoiding certain compounds in beer or the need to involve new ones in the brewing recipe has broadened the market for the brewing industry and made beer more accessible to consumers who, till now, avoided beer. Low-alcohol, non-alcohol, radlers are today's craze among consumers. Not only beer has been recognized as a platform for functional beverages, but wort as well. In some countries wort-based beverages are traditionally consumed, and this trend seeks its way into regional market as well. Many breweries started producing wort-based beverage mixtures with different flavors and juices which add value to it.
Evaluation of quality traits and yield in NS barley varieties during the 2023/24 growing season
Authors: Brbaklić Ljiljana , Pejin Jelena , Pribić Milana , Mirosavljević Milan , Mikić Sanja , Živančev Dragan , Bursać Vojislav , Nemeš Robert
Published: December 2024

Breeding of malting barley at the Institute of Field and Vegetable Crops in Novi Sad has a tradition spanning more than seventy years. During this period, a large number of winter and spring barley varieties have been developed and registered, which have stood out for their high genetic yield potential and good technological quality required for malt production. The aim of this study was to examine two-row winter barley varieties that have been developed at the Institute of Field and Vegetable Crops over the past 10 years and registered for the malt industry. A total of six NS varieties were tested at the Rimski šančevi location in the 2023/24 season. The experiment was set up in a randomized block design on 10 m² plots with four replications, applying standard cultivation practices. All necessary pathogen control treatments were applied in three replications, while the fourth replication served as a control and was untreated. During the growing season and after harvesting, important agronomic traits were recorded: heading, number of ears per m², disease occurrence, lodging resistance, grain yield, protein content, and all important technological quality parameters obtained from the micro-malting process. All tested varieties had uniform heading within a three-day interval (April 10-13, 2024). Protein content in the treated block ranged from 9.4% to 11.2%, while protein levels in the untreated block were higher, ranging from 9.9% to 13.3%. The percentage of first-class grain for all varieties was over 95%. Dry extract values ranged from 76.7% to 80.3%. The Kolbach index varied from 33.4 to 42.1, and the Hartong value ranged from 33.2% to 40.7%. All varieties demonstrated excellent lodging resistance. Increasing demands from the industry and the growing demand for new beer flavors, both in large multinational companies and small craft breweries, present an excellent opportunity for the use of NS malting barley varieties in malt production, which would ensure greater diversity in the available assortment, excellence, and create new challenges and uniqueness in beer production.
Application of lyophilization for immobilization of yeast cells in polysaccharide carriers
Authors: Obradović Nataša , Balanč Bojana , Đorđević Verica , Volić Mina , Stanisavljević Nemanja , Nedović Viktor
Published: December 2024

Immobilized yeast cells have significant potential for application in the fermentation of alcoholic beverages due to their technical and economic advantages over free-cell systems. Polysaccharide carriers have proven to be an effective solution for improving cell viability and protection during fermentation processes. This study aims to immobilize Saccharomyces pastorianus yeast cells using the lyophilization technique. Suspensions were prepared by mixing sodium alginate and maltodextrin (1.5%) with cells harvested during the early exponential growth phase. After lyophilization, the powders were analyzed for yield, cell viability, moisture content, particle size, and z potential. The microstructure of the carriers was examined using scanning electron microscopy (SEM). The moisture content and solubility of both types of carriers were similar, and the low moisture content indicates the microbiological stability of polysaccharide carriers, making them suitable for application in the food industry. The viability of immobilized cells in the carriers was significantly higher (>74.3%) compared to free cells (64.2%). The average particle diameter was 7.4 ± 0.2 µm for alginate and 7.2 ± 1.2 µm for maltodextrin. The surface charge of all samples was measured to confirm the physicochemical stability of the carriers, with negative charges observed in all samples. The low values in the control sample indicate the tendency of free cells to aggregate, highlighting the role of carriers in maintaining system stability. SEM micrographs demonstrated successful cell immobilization and reduced porosity in the carriers containing maltodextrin. These results confirm the effectiveness of polysaccharide carriers in cell immobilization and protection, as well as their potential for industrial use.
Yitik hazinenin peşinde: Risale-i Sufiyye-i Safeviyye üzerine değerlendirme
Authors: Vayghan Manizhe Ghodrati
Published: December 2024

This study deals with the work titled ‘Risale-i Sufiyye-i Safaviyye’. The work was written in Persian
prose in the eleventh Hijri century. In this study, the introduction of the Safaviyya sect source, which
deals with the principles of the sect of the Safaviyya sect and is not known by the academic circles, has
been made. The Sufi aspect of the Safavid State or Ardabil tekke has remained in the background. The
reason for this is that there is insufficient information and resources on the manners and manners of the
Safavids or Ardabil tekke. The work that is the subject of this study provides sufficient information about
the principles of the sect of the Safavids or Ardabil Tekke. The introduction of this work contributes
to the rediscovery of the beliefs, customs, manners and organisational structure of the Safavid order.
This manuscript is one of three risales included in the collection “Tezkiretü’z-Zâkirîn” registered under
number 356 in the Sultanî Madrasah Library in Kashan. This collection was edited by Afşin Âtıfî in
1391/2012 and published by Hamgâm-ı Hestî Publications in Kashan. “Risale-i Sufiyye-i Safeviyye”
was penned by Mirza Muhammad b. Sultan Muhammad, also known as Muhakkık al-Erdebîlî Bidgoli,
in 1051/1641. The author’s birth date is unknown, but the inscription on his tomb wall indicates that he
passed away in 1090/1679. According to his will, he was buried in the lower part of the mosque where
he lived and taught. “Risale-i Sufiyye-i Safeviyye” is one of the Sufi works attributed to Muhakkık al-
Erdebîlî. He stated that the purpose of writing this risale was to awaken the followers of the Safavid
order against their sheikhs and guides and to provide guidance and enlightenment to its seekers and
adherents.
Şah İsmayılın xarici görünüşü
Authors: Süleymanov Mehman
Published: December 2024

The article is dedicated to the physical and external appearance of Shah Ismail Safavi, who
founded the Safavid state of Azerbaijan. There is no extensive information about this topic
in the sources. That is why the appearance of Shah Ismail Safavi arouses legitimate interest
in readers and researchers. It is known that Shah Ismail (Ismail Mirza) took part in battles
from a very young age and fought against his enemies together with his warriors. If Shah
Ismail did not have enough physical strength, he could not have won these battles. There
are also precious images about this in oriental miniatures. Western artists also addressed
the subject of Shah Ismail and created a number of works. The best of them is a portrait
painted in 1568 by the Italian artist Cristofano Del’Altissimo. However, Shah Ismail’s hat in
this portrait does not look like a gızılbash hat at all. The article devoted a lot of space to this
issue and made a scientific comparison of the hat drawn by the Italian artist by referring to
historical facts.
Cüneyd’den Şah İsmail’e kadar Şirvan mücadelesi: Tarihi ve milli arka plan
Authors: Bayat Fuzuli
Published: December 2024

In this article, the struggle of the Safavids’ predecessors, the Karakoyunlu and Akkoyunlu
units, to establish a centralized state is mentioned. It is known that the Shirvanshahs
preserved their existence in one form or another throughout a long historical period,
from the Oghuzs, Seljuks, Mongols, Teymurids, Akkoyunlu and Karakoyunlu states to the
Safavids. In the article, the Safavid sheikhs’ Shirvan expeditions and their eventual end to
the independence of this state are discussed in terms of both historical reality and national
ideology. For this purpose, the Safavid Shirvanshah struggle was researched by referring
to old sources and especially the works of recent historians. Although the Safavid Qizilbash
State has been researched in many aspects, it is also a fact that some issues have been
little or not sufficiently researched. In both Turkish and Azerbaijani historiography, the
stubborn march of Savefi sheikhs Juneyd, Haydar and Ismail on Shirvan, the murder of the
previous two sheikhs and the defeat of the last one by the Shirvanshah army, effectively
ending the existence of this state, were attributed to revenge motives. However, the political
situation of the XV-XVI centuries created the conditions for the Safavids to come to power
in Eastern Anatolia, Azerbaijan and Iran, and the establishment of the state was linked to
the elimination of the Shirvanshahs.
Şah İsmayıl - şeyxlikdən şahlığa
Authors: İbrahimova Ülviyyə
Published: December 2024

The founder of this state, known in history as both the Qizilbash state and the Safavid
state, Shah Ismail, the head of the Safavid sect, joined the political struggle as a sheikh
and became the head of state after achieving his goal. The Safavid order, to which Ismail
I belonged, played a major role in the creation of this state, and their main force was the
Turkic tribes called the Qizilbash. Gilzalbashism, which began to spread rapidly from the
time of Sheikh Junayd, became the main trend during the time of Sheikh Ismail, which
protected him from enemy forces and turned him in the eyes of the people into the leader of
the opposing righteous forces. While still in Lahijan, the Sufis of Karajadag, Ahar and Talysh
tried to be with Ismail. Ismail’s main task as a sheikh was to protect this mission entrusted
to him. Under the conditions arising from the requirements of the time, Sheikh Ismail, in the
role of Shah Ismail I, fulfilled his mission as a sheikh, dominating the territory of the large
state he created. However, the ideology proclaimed this time was very different from the
initial one. Thus, during the times of Sheikh Junayd and Sheikh Heydar, the Safawiye order
partially lost its initial character and separated from its Sufi essence. For the sheikhs, who
had already become property owners, it was almost impossible to remain Sufis. The Safavid
sheikhs, who gradually developed towards Shiism, were in fact ready to act according to
all the political rules necessary for state building, and this is confirmed by their policies
starting from the 15th century. Having declared himself Shakh, Sheikh Ismail implemented
this policy with great skill.
Şah İsmail ve Osmanlı edebiyatı (nazireler örneğinde)
Authors: Musalı Vusala
Published: December 2024

The censorship of Azerbaijani literature during the Soviet period also limited the study of Azerbaijani-
Ottoman literary relations. For this reason, the biographies and art of Azerbaijani poets who lived in the
Ottoman Empire during the 15th-19th centuries, the literature of migration, and Azerbaijani-Ottoman
literary interactions have been understudied. Written sources, especially Ottoman biographies,
anthologies, and poetry collections, play a vital role in studying these relations and the place of
Azerbaijani poets in the Ottoman literary environment. This study examines the parallels (nazira) that
Shah Ismail Khatai drew with the poems of Ottoman poets and the reactions of Ottoman poets to his
poems, based on Ottoman biographies (tazkira) and poetry collections (majmua). Two Ottoman nazira
collections (Majmua-i Nezair and Pervane Bey’s Majmua) are important sources for studying the
literary connections of Azerbaijani poets with Ottoman poets. These works include parallels that Shah
Ismail Khatai wrote with the poems of poets such as Ahmed Pasha, Jem Sultan and Nizami, as well as
responses by Ottoman poets to Khatai’s poems. The parallels drawn by Ottoman poets with Khatai’s
poems reveal the place that Azerbaijani poets occupied in the Ottoman literary environment. Despite
the political tensions between the Safavids and the Ottoman Empire in the 16th century, literary relations
seem to have continued. The parallels that Shah Ismail Khatai drew with the poems of Ottoman poets
and the responses that Ottoman poets wrote to his poems prove that literary relations in this context
have a feature that goes beyond borders. The aim of this study is to uncover the interaction between
Ottoman and Azerbaijani literatures by assessing the literary links between the two cultures in the light
of naziras and poetry collections.
Şah’ın gölgesinde: Avusturya’da Şah Hatayi’nin izleri
Authors: Kalaycı Erdal
Published: December 2024

Alevism in Austria has been recognized as a public legal entity since 2013. Following this
recognition, the Alevi Faith Community of Austria (ALEVI) has actively engaged in various
fields and implemented exemplary initiatives. One of the key outcomes of this recognition
has been the introduction of Alevi religious education in schools. This development provides
Alevi children and youth with the opportunity to learn about their faith in an institutionalized
educational setting. Oversight and administration of this educational initiative fall under
the purview of the Alevi Education Department. Institutions such as the University of
Vienna and the Church University College of Teacher Education Vienna/Lower Austria play
a pivotal role in the academic and professional development of Alevi theologians, faith
educators, and spiritual counselors. Furthermore, the Hızır Austria charity organization has
been established to oversee humanitarian aid efforts, while the Funeral Fund is tasked with
managing matters related to final rites and ceremonies. The Şah Hatayi Cemevi in Vienna
serves as the central hub for the Alevi community in Austria, providing a space where
members convene to engage in social, cultural, and religious practices. Significantly, it is the
first Alevi house of worship to receive official state recognition, marking a milestone in the
institutional representation of Alevism in Austria. The naming of this cemevi is deliberate,
reflecting the Alevi Faith Community’s ties to the Erdebil Dergah and its reverence for Şah
Hatayi as a religious role model and central figure. This article seeks to elucidate the legacy
of Şah Hatayi and his enduring influence on the activities and organizational framework of
Alevis living in Austria. It further explores how his teachings continue to shape the faith and
cultural practices of the Alevi community in a diasporic context.
Safevi Sarayı’nda XVI. yüzyıl’da müzik teorisi kaynakları üzerinden Şâh İsmail Hatayi’nin düşünce dünyasının tahayyül edilmesi
Authors: Güray Cenk
Published: December 2024

Sources of music theory in Medieval Islam Period named as “edvâr” sources, are of great
importance for the cultural history of the region not only for having contained some music
theory information about the historical period they belong to such as the tuning system,
melodic structures, rhythmic structures, but also reflecting a strong “cosmic perception”
by establishing a connection with the “theory of cycles”. The principles of medieval Islamic
states of establishing the relationship between “belief and music” through the contradiction
or reconciliation of the “madrasah-tekke” traditions utilizing the sources of music theory
had created a rich written literature in this field that can be useful in terms of both education
and philosophical methodology. It is noteworthy that a small number of these sources were
produced at or in relation to the Safavid court. By examining these sources, this study
endeavors to search for the roots and tradition of Shah Ismāʿil Khatāyi’s cycle-based
“cosmic perception” reflected in his poems/breaths within the artistic and cultural life of the
Safavid court and its capital. This tradition was influenced by the stylistic characteristics
of the Khorasan/Herāt and Azerbaijan/Tebriz schools of art and philosophy, as well as the
“mystical beliefs” that are widespread in these regions. The meeting of these influences
with the Ottoman artistic tradition and “minstrel poetry-music” in Anatolia created a unique
artistic field that enabled Safavid culture to meet the Anatolian culture. This connection
can also define Shah Hatayi’s connection to the Khorasan-Anatolian-based school that can
be seen as the main philosophical school of Medieval Anatolia as adressed in this article.
Social Engineering with the Rough Set Theory
Authors:   Assistant Professor, Department of Mathematics, Queens College of Arts and Science for Women, Pudukkottai, Tamil Nadu, India, M Gayathri , M Uma Maheswari ,   Assistant Professor, Department of Mathematics, V.V. Vanniaperumal College for Women, Virudhunagar, Tamil Nadu, India.
Published: December 2024

This paper explores applying rough set theory and cluster analysis to study social engineering, particularly focusing on identifying community patterns and differences. Social engineering, in this context, refers to the manipulation and influence of individuals or groups to achieve specific outcomes, often through deception. By employing rough set theory, we handle imprecise or incomplete data, which is common in real-world social dynamics. Cluster analysis is then used to group communities with similar attributes, enabling the identification of shared characteristics and anomalies. This approach aims to provide deeper insights into how social engineering tactics are applied across different community structures, helping to develop more robust countermeasures. The findings contribute to both the theoretical understanding of social manipulation and practical interventions to protect vulnerable populations.
Atividade física e qualidade de vida de idosos participantes de programas de extensão universitária durante a pandemia da Covid-19
Authors: Gonçalves Andrea Kruger , Martins Valéria Feijó , Fank Felipe , Antunes Gabriel Aguiar , Gil Priscila Rodrigues , Mazo Giovana Zarpellin
Published: December 2024

Objetivo: verificar a associação entre a autopercepção do nível de atividade física com a qualidade de vida relacionada à saúde (HRQoL) em idosos brasileiros durante a pandemia da COVID-19. Metodologia: Trata-se de um estudo transversal, que envolveu 274 idosos de programas de extensão de universidades públicas do sul do Brasil. O nível de atividade física (NAF) foi avaliado pela autopercepção do idoso, por meio da questão “Como você avalia seu nível de atividade física na pandemia?”. A HRQoL foi avaliada pelo 12-item Health Survey. Os dados foram analisados pelo teste de variância one-way e regressão logística múltipla (p<0.05). Resultados: A média de idade dos idosos foi de 71.2±6.33 anos, sendo 244 mulheres e 30 homens. Os resultados indicaram que idosos ativos, de acordo com sua autopercepção do NAF, apresentam maior pontuação em todos os componentes e domínios da HRQoL quando comparados aos idosos que se autodenominam insuficientemente ativos e inativos (p<0.001). Na regressão logística, o modelo ajustado identificou que idosos insuficientemente ativos têm maior chance de apresentar HRQoL reduzida em todos os componentes (p<0.001). Em relação aos domínios, estes idosos têm 4.44 (IC95%: 2.47-7.99) e 4.84 (IC95%: 2.51-8.02) vezes mais chance de apresentar o domínio físico e domínio mental reduzidos, respectivamente. Conclusão: idosos que se consideraram fisicamente ativos durante a pandemia da COVID-19 têm melhor qualidade de vida, quando comparados aos que se percebem insuficientemente ativos ou inativos. Ainda, os idosos que se consideram insuficientemente ativos ou inativos fisicamente apresentaram maior chance de terem uma qualidade de vida reduzida durante o período de isolamento social. Demonstrando, o impacto do nível de atividade física na qualidade de vida dessa população durante a pandemia da Covid-19. O que denota a importância desses programas para a qualidade vida dessa população e do viés social das Universidades diante do seu potencial de promoção da saúde comunitária.
El rol de la Corte Electoral en la Ley 20.292 de partidos políticos
Authors: Bello Hernán
Published: December 2024

El 14 de junio de 2024, el Parlamento Nacional sancionó la Ley 20.292, en la que dispuso una serie de modificaciones a la Ley 18.485, relacionadas principalmente al financiamiento de los partidos políticos. La Ley 20.292 determinó también varias atribuciones específicas a diferentes organismos de contralor estatal, entre ellos, y fundamentalmente, la Corte Electoral. El presente trabajo consistirá en mencionar y estudiar dichas atribuciones, las cuales considero de suma importancia y trascendencia en lo que refiere al financiamiento de los partidos políticos y a la publicidad de carácter electoral.
Cytokine TRAIL death receptor agonists: design strategies and clinical prospects
Authors: Yagolovich A. V. , Gasparian M. E. , Isakova A. A. , Artykov A. A. , Dolgikh D. A. , Kirpichnikov M. P.
Published: December 2024

The development of therapeutic bispecific antibodies and hybrid proteins is one of the most urgent biomedical technologies with obvious clinical prospects. At the same time, advanced strategies of molecular design of drugs with new properties are coming to the forefront. The tumour necrosis factor-related apoptosis inducing ligand (TRAIL) receptor pathways are important components of the immune system involved in the immune surveillance and selective elimination of transformed cells. TRAIL-based proteins are therefore promising drug candidates for the treatment of malignant tumours and autoimmune diseases. In the first series of clinical trials, drugs targeting the death receptors DR4 or DR5, did not show significant anti-cancer activity. This is due to the TRAIL resistance mechanisms that tumours evolve to evade the efficient induction of apoptotic signalling. However, a wide range of novel TRAIL death receptor-targeted formulations are currently being developed, mainly to improve stability, enhance death receptor clustering and involve additional tumour targets. Over the past decade, several dozens of multi-targeted fusion proteins with either TRAIL protein or DR5-specific agonistic monoclonal antibodies have been developed to improve therapeutic efficacy. These include fusions with either short peptide tags or large functional proteins, as well as antibody fragments targeting molecular pathways involved in angiogenesis or proliferative signalling such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), programmed death-ligand 1 (PD-L1), etc. Collectively, these multimodal proteins enhance the activation of extrinsic and intrinsic apoptotic pathways in transformed cells, as well as affect the tumour microenvironment. This comprehensive review systematizes the bispecific and multivalent fusion proteins and conjugates targeting TRAIL death receptors, analyze the molecular mechanisms by which they overcome tumour resistance to TRAIL, and assess their clinical prospects.
The bibliography includes 236 references.
Pengaruh Pemberian Konsentrat Mengandung Eucheuma Cottonii Afkir Terhadap Konsumsi dan Kecernaan Karbohidrat dan Glukosa Darah Sapi Bali Betina Muda yang Mengonsumsi Pakan Dasar Silase Rumput Alam atau Fodder Jagung
Authors: Arianto Timoteus , Benu Imanuel , Ernawati Luh Sri
Published: December 2024

This study aimed to determine the effect of concentrate containing fermented Eucheuma cottonii on carbohydrate intake, digestibility, and blood glucose levels in young female bali cattle. The study used a 4x4 Latin square design with four treatments: 60% Natural Grass Silage + 40% E. cottonii Concentrate Without Fermentation, 60% Natural Grass Silage + 40% E. cottonii Concentrate With Fermentation, 60% Corn Fodder + 40% E. cottonii Concentrate Without Fermentation, and 60% Corn Fodder + 40% E. cottonii Concentrate With Fermentation. The results showed that carbohydrate intake ranged from 2138.75 to 3813.13 g/head/day, while blood glucose levels ranged from 78.43 to 120.00 mg/dl. Concentrate containing fermented E. cottonii reduced carbohydrate intake (P<0.05) but did not affect carbohydrate digestibility or blood glucose levels. Overall, fermented E. cottonii concentrate did not improve feed intake performance or digestibility.
Nurturing Earth's Foundation: A Comprehensive Review of Soil Conservation Strategies, Challenges and Solutions
Authors: Ghimirey Vivek , Chaurasia Jay , Acharya Nobel , Dhungana Roshni , Marahatta Saurav
Published: December 2024

Depending on the country, many challenges affect the availability and quality of food, as well as their nutritional status. This is due to intensive agriculture and the exploitation of external inputs, which are degrading the soil, water, and genetic resources, thereby affecting agricultural performance. Soil conservation is an effective and environmentally friendly technique for promoting modern agriculture that helps in the production of food without hurting the environment. Some of the systematic measures used in soil conservation are contour cultivation, terrace cultivation, cover crops, crop rotation, agroforestry, and the like. However, the application of these strategies is not exempt from difficulties, although they are one of the most promising sustainable solutions. These challenges include technological difficulties, the adoption of conservation tillage practices, and long-term research priorities. This is an attempt to provide a brief overview of various strategies in the field of soil conservation, the multifaceted challenges that arise in these processes, and the methods employed to address these difficulties. In conclusion, we feel that the Ministry needs to organize training programs on adequate measures for soil conservation, as policy assistance concerning capacity building is crucial. Given the challenges identified, it may be effective to introduce the elements of soil conservation into the ministries, departments, or institutions concerned and encourage local stakeholders to participate in the process of solution acceptance and implementation.