bluuebunny/crossref_metadata_2025 huggingface dataset:
Феномен їдальні у повсякденних практиках студентства підросійської України останньої чверті ХІХ – початку ХХ ст.
Authors: Кругляк Марина
Published: October 2023

Метою статті є показати історію появи такого феномену студентської повсякденності, як їдальня; продемонструвати умови її функціонування та довести безальтернарнативність її існування як місця, де здійснювалося харчування студентства підросійської України останньої чверті ХІХ – початку ХХ ст. Методологія дослідження ґрунтується на поєднанні загальнонаукових (аналіз, синтез, узагальнення, порівняння, систематизація), спеціально-історичних методів (історико-структурний, конструктивно-генетичний, історико-компаративістський) із науковими принципами об’єктивності, системності, історизму. Наукова новизна роботи полягає в тому, що вперше у вітчизняній історіографії здійснено спробу окреслення феномену студентської їдальні як невід’ємної складової повсякденного життя молоді, що здобувала освіту у вищих навчальних закладах підросійської України останньої чверті ХІХ – початку ХХ ст.; продемонстровано вартість студентського харчування й зруйновано популярний у радянській історичній науці міф про «вічноголодного студента». Висновки. Поява студентської їдальні, без якої неможливо уявити сучасний вищий навчальний заклад, як невід’ємної складової студентської повсякденності стала можливою в останній чверті ХІХ ст. Це було явищем закономірним, зважаючи на зростання чисельності студентства, демократизацію його соціального складу, розширення мережі вищих навчальних закладів, скасування існуючих при університетах підросійської України інститутів казеннокоштних студентів, зростання рівня самоідентифікації та самоорганізованості студентства тощо. Будучи закладом, безумовно, потрібним для систематичної організації харчування значної кількості молоді, їдальня з часом перетворюється на одне із місць революційної діяльності студентства. Пропоновані страви, хоч часто й були доступні студентові, все ж не завжди відзначалися високою якістю й подеколи призводили до появи в молоді хронічних захворювань кишково-шлункового тракту. Тим не менш, альтернативні заклади харчування (паштетні, ресторани, приватні їдальні), через свою елітарність та дорожнечу, користувалися популярністю тільки серед заможного студентства. Для незаможної молоді студентська їдальня, по суті, залишалася безальтернативною формою не лише організації дешевого харчування, але й невід’ємною складовою повсякденності, свідченням цього є численні спогади студентів та студентська творчість.
How Negative Is the Theology of Dionysius the Areopagite?
Authors: Edwards Mark
Published: October 2023

This paper considers three recent studies on the negative theology of the Neoplatonists and Dionysius the Areopagite. The first is that of Lloyd Gerson, who argues that the One in Plotinus does not lack transcend existence but only definite existence; the second is the contrary thesis of Eric D. Perl that not only the One of Plotinus but the God of Dionysius transcend all being in such a way that they cannot be credited with existence. After some criticism of both the paper turns to the argument of Timothy D. Knepper that even the ineffability of the divine cannot be stated on our present plane of knowledge; it concludes with some reflections on the appeal to present or future experience as alternatives to epistemology as this is commonly understood in the analytical tradition of philosophy.
The Source Antinomy of the Mystery of the Trinity as the Foundation and Hermeneutical Key of Christian Apophaticism in the View of Vladimir N. Lossky
Authors: Płóciennik Michał
Published: October 2023

For some time now, there has been a definite revival of interest in apophatic theology within religious thinking as well as at its antipodes. It often takes the form of criticism of religion, including Christian Revelation, and thus the theology based on it. From a Christian perspective, this provides an invitation to reflect on the rich heritage of apophaticism and to show its specificity as a consequence of what constitutes the specificum christianorum, i.e. the Trinitatis mystery. Important clues in this regard can be found in the thought of Vladimir N. Lossky, a prominent 20th century Orthodox theologian, a radical defender of the specific apophatic nature of Christianity and a theologian faithful to Trinitarian orthodoxy. Looking at the most important issues related to the Trinitarian dogma, we will point out that in the Russian’s view, the Trinitarian antinomy is the source and foundation of Christian apophaticism and its hermeneutics. This conclusion will be based on revealing the Trinitarian antinomy as what is primordial, unconditioned by nothing, non-derivable from anything and therefore as a purely religious given and truth par excellence, accessible to man through Its free Revelation, which It also infinitely transcends.
One God – Many Religions? The Role of Negative Theology in Contemporary Interpretations of Religious Pluralism
Authors: Kałuża Krystian
Published: October 2023

The article discusses the role of negative theology in contemporary interpretations of religious pluralism in an analytical and synthetic way. One of such interpretations is the pluralistic theology of religion. In view of the problems encountered due to such a way of looking at religions, a different direction of interpretation is proposed in the article. Accepting the validity of the basic intention of negative theology, the author presents a thesis that a Christian theology of religious pluralism can be based on Trinitarian theology as a kind of “matrix” of religious experience. A systematic criterion was used in the elaboration of the subsequent steps: (1) The faces of transcendence, (2) The pluralist hypothesis, (3) Via negativa, (4) The limits of negation, (5) Experience and language, (6) The nature of transcendence, (7) Toward a Trinitarian interpretation of religious pluralism. The presented model of Trinitarian interpretation of religious pluralism can be called an integrative model. It is based on the assumption that it is possible to demonstrate certain similarities between the properties of the individual Persons of the Trinity and various ideas and concepts of Ultimate Reality found in different religions.
Apophaticism, Mysticism, and Epoptics in Ancient and Patristic Philosophy: Some Important Examples
Authors: Ramelli Ilaria
Published: October 2023

This article investigates mystic apophaticism in a set of Greek Patristic theologians, profoundly informed by philosophy, especially imperial Platonism: Clement, Origen, Gregory of Nyssa, and Pseudo-Dionysius. Both the terminology and the argumentative structure will be examined in each author and important connections among themselves and with ‘pagan’ Neoplatonists (including Plotinus, Porphyry, and Proclus) will be drawn. The reciprocal interrelations among epoptics, ἔρως and ἀγάπη, epektasis, and ἐπιστροφή and ἀποκατάστασις will be pointed out. The article will argue for the intended double-reference strategy to both ‘pagan’ and Christian Platonism, as well as Dionysius’ veiled response to Porphyry qua accuser of Origen, and the meaning of the charge, levelled against Dionysius himself, of “making unholy use of Greek things”—which is what ‘pagans’ had already charged Origen with. Dionysius retorted, “it is the Greeks who make unholy use of godly things to attack God!”, and this is again what Origen had responded.
Hipercalcemia severa: Debut inusual de Leucemia Linfoblástica Aguda (LLA) en la infancia
Authors: Dick Zambrano Carmen , Gómez Romero Douglas
Published: October 2023

La hipercalcemia severa es una manifestación clínica infrecuente como debut de Leucemia linfoblástica aguda (LLA) en la infancia en relación a la etapa adulta. Presentamos el caso de un varón de 14 años de edad con Leucemia linfoblástica aguda e hipercalcemia como presentación inicial de su enfermedad, en quién se obtuvo recuento leucocitario en su rango normal para la edad. Sin embargo, se evidenció bicitopenia con afectación de serie roja (anemia normocítica normocrómica) y plaquetaria (trombocitopenia), con presencia de células atípicas en extendido de sangre periférica. Además, se realizó mielograma en el aspirado de médula ósea observándose presencia de blastos en serie linfoide en un 32 %. No se hallaron imágenes infiltrativas ni líticas en serie ósea. La hipercalcemia fue tratada con bifosfonatos, obteniéndose buena respuesta terapéutica con mejoría clínica evidente.
Birleşmiş Milletler sürdürülebilir kalkınma amaçları ışığında Türkiye Cumhuriyeti kadının güçlenmesi eylem planı 2018-2023
Authors: EDİNSEL Sercan
Published: October 2023

Bugünün küresel kuruluşları, sürdürülebilir ve kapsayıcı bir geleceğin oluşturulması kapsamında elindeki insan kaynakları gücünü düzenlemek için çabalamaktadır. Bu düzenleme açısından toplumsal cinsiyet eşitliğinin sağlanarak kadınların işgücüne aktif olarak katılımı büyük önem taşımaktadır. Birleşmiş Milletler (BM), öncü bir örnek olarak, mevcut ve gelecekteki sorunların çözümüne katkıda bulunmayı amaçlamaktadır. BM'nin bu çabalardaki temel referansı, 2030 Sürdürülebilir Kalkınma Amaçları olarak adlandırılan geniş çerçevedir. Bu çerçevenin 5’inci maddesi ise “Toplumsal Cinsiyet Eşitliği”dir. Türkiye’de 2015 yılında Birleşmiş Milletler'in öncülük ettiği bu adımı resmi olarak benimsemiştir. Bu taahhüdüne istinaden 'Kadının Güçlenmesi Eylem Planı (2018-2023) devreye sokmuştur. Çalışmanın amacı BM Sürdürülebilirlik Amaçları kapsamında oluşturulan kodların 2018-2023 Kadının Güçlenmesi Eylem Planında geçen faaliyetler ile ilişkisini tespit etmektir. Bu kapsamda olgubilim araştırması ile içerik analizi yöntemi uygulanmıştır. 2018-2023 Kadının Güçlenmesi Eylem Planında eğitim, ekonomi, karar alma mekanizmalarına katılım, sağlık ve medyadır. Çalışmada kullanılan kodlar nitelikli eğitim, cinsiyet eşitliği, eşitsizliklerin azaltılması, insana yakışır iş, güçlü kurumlar, ekonomik büyüme, sürdürülebilir şehir-topluluk, barış ve adalet olarak belirlenmiştir. Çalışmanın sonucunda nitelikli eğitim, cinsiyet eşitliği ve eşitsizlikleri azaltma, güçlü kurumlar ve adalet kodlarının 2018-2023 Kadının Güçlenmesi Eylem Planında geçen faaliyetler ile ilişkisi olduğu tespit edilmiştir. Ayrıca çalışmanın sonucunda bu alanda devlet, kurum ve işletmelere yapılması gerekenler konusunda önerilerde bulunulmuştur.
Історична фонетика і граматика української мови
Authors: Колоїз Жанна Василівна
Published: October 2023

У навчальному посібнику репрезентовано стислу інформацію з історії розвитку української мови, її фонетичної й граматичної підсистем. Основні теоретичні відомості, що супроводжують конкретну тему кожного з трьох змістових блоків, узагальнено й представлено у вигляді таблиць, розміщених в одному з додатків. Інший додаток містить фрагменти давніх текстів, необхідні для комплексного аналізу. Запропоновано низку практичних завдань, скерованих на сприйняття, усвідомлення й розуміння тих фонетичних і граматичних явищ, які відбувалися на різних етапах становлення української мови. Задля закріплення знань, вироблення необхідних умінь і навичок передбачено завдання тестового контролю до кожного змістового блоку. Адресовано передовсім студентам-філологам.
Kepentingan Nasional Indonesia Menjadikan Kawasan Kars Gunung Sewu Sebagai Unesco Global Geopark Network (GGN)
Authors: Shunu Rahadyan Arka , Hartati Anna Yulia
Published: October 2023

This research is a contemporary study that addresses Indonesia's national interests to make Gunung Sewu a UNESCO Global Geopark Network. Global Geopark Network is a network with the name UNESCO that has a role to preserve the geological heritage and promote sustainable development in the community. Whereas Gunung Sewu is a karst region that is rich in tourism potential and geological heritage. In this study, the author focuses on the importance of the basic Indonesia to make Gunung Sewu the Global Geopark Network. The researcher used Felix Oppenheim's theory of national interests which stated that national interests were the ideals or goals of the state to prosper. As well as perspective from Joshua Goldstein that in order to achieve the goals of a country, a country cooperates with other parties. Based on the analysis and data, it is known that the national interests that Indonesia wants to achieve are our economic interests, namely increasing state revenues from the tourism sector and conservation interests to preserve the nature of mountain waste for the survival of the community.
Kerjasama Otoritas Jasa Keuangan (OJK) Dengan Monetary Authority Of Singapore (MAS) Dalam Bidang Teknologi Finansial
Authors: Malchan Muhammad Ilyas Balya , Ismiyatun Ismiyatun
Published: October 2023

This research discusses globalization and the technological revolution, which is increasingly developing technology and information. The mobilization of the world community is also growing and more complex. This is what triggers globalization to occur because trade and financial movements can become easier to do. The author wants to describe the objectives and reasons for the Financial Services Authority in collaboration with the Monethary Authority of Singapore in the field of financial technology. By using the theory of National Interest, which is defined as the ability of a country to protect its physical identity, political identity and cultural identity. National interest is both a tool and a goal to be used as a medium to achieve the national goals of a country. The level of analysis used is the domestic influence because it is related to activities that occur at the country level. The type of research in this paper is qualitative analytic with secondary data. The author also describes the background for the formation of cooperation, the dynamics in the continuity of cooperation and the condition of financial technology in Indonesia. At the end of the research, the reasons for the cooperation between OJK and MAS are explained, namely technological developments, strengthening economic foundations and information exchange.
Keikutsertaan Anak Anak Dan Perempuan Dalam Perang Menurut Kitab Fathul Qorib
Authors: Ahdi Wafi , Purwono Andi
Published: October 2023

This study aims: To determine the concept of the principles of applicable Islamic law and International Humanitarian Law regarding war; To know the implementation of the principles of applicable Islamic law and International Humanitarian Law regarding War; The scope of this research is the principles of Islamic Law regarding the regulation of war in International Humanitarian Law regarding the involvement of children and women in war; The research method, using a normative juridical approach, is a law-oriented research method that regulates the principles of Islamic law regarding war in International Humanitarian Law. This means collecting primary and secondary data, and tertiary data based on the object of research. The data in question is processed descriptively. The results of the study found that: From a juridical point of view, the Islamic Law System and humanitarian law question the protection of the rights and obligations of the civilian population against the rules regarding how to resolve conflicts and the consequences of the conflict itself. Implementation of the Islamic law system and humanitarian law in regulating legal protection for humans due to armed conflict, namely the existence of fair treatment of fellow human beings as well as respect and protection in the sense that the humanitarian element must be prioritized, so as to prevent acts that excessive as contained in the Geneva Conventions of 1949 and its Additional Protocol to Islamic Law derived from the Qur'an and Al-Hadith. This is meant, broadly speaking, stipulating a prohibition on killing civilians who did not participate in the war, killing children, women and the prohibition of destroying cultural objects, places of worship and other places of benefit.
Efek Perbedaan Kecepatan dan Kedalaman Potong pada Mesin Bubut terhadap Tingkat Kekasaran Benda Kerja ST 37
Authors: Nurlela Nurlela , Ikhsanudin Ikhsanudin
Published: October 2023

Pembubutan merupakan pekerjaan yang sering dilakukan pada bidang teknik pemesinan. Tujuan penelitian ini adalah untuk menjelaskan pengaruh variasi proses pembubutan terhadap tingkat kekasaran pada benda kerja. Variasi proses pembubutan yang dimaksud adalah perbedaan kecepatan dan kedalaman potong bubut. Penelitian ini dilakukan dengan menggunakan metode eksperimen. Variabel meliputi variabel independen yakni kecepatan potong dan kedalaman potong dengan variabel dependen kekasaran permukaan benda kerja. Dari hasil percobaan dapat disimpulkan bahwa kekasaran permukaan benda kerja hasil pembubutan dipengaruhi oleh kecepatan dan kedalaman potong. Secara konsep, semakin tinggi kecepatan potong maka semakin halus benda kerja yang dihasilkan, namun belum nampak jelas pada percobaan ini. Kemudian terkait kedalaman potong, semakin dalam pemakanannya maka semakin halus (kekasaran kecil) permukaan benda kerja hasil pembubutan, terbukti pada percobaan ini. Dengan demikian, pada proses pembubutan diperlukan kecepatan dan kedalaman potong yang tepat sesuai dengan jenis benda kerja untuk memperoleh hasil yang terbaik. Kajian lebih lanjut dapat dilakukan dengan kecepatan dan kedalaman potong yang lebih bervariasi.
Preparation of Idebenone as a Thermosetting Nasal Gel for Better Bioavailability and Histopathological Effect
Authors: Kadhim Hussein J. , Al-Kinani Khalid K.
Published: October 2023

خلفية Idebenone هو دواء يتم استقلابه على نطاق واسع مع ضعف ذوبانه في الماء ويستخدم لعلاج الاعتلال العصبي البصري الوراثي لليبر. الهدف تهدف هذه الدراسة إلى تحضير مستحلب الإيدبينون النانوي كجل أنفي يعتمد على البولوكسامير للتغلب على المعدل الكبير للاستقلاب الكبدي من أجل توافر حيوي أفضل وتقليل التأثير المرضي النسيجي على الغشاء المخاطي للأنف. 
الطرق: استندت استراتيجية العمل إلى تقليل التركيز المتبادل بين المستحلب النانوي والمستحلب النانوي. الجل الناقل عن طريق ضبط درجة حرارة الجيل بين 30-32 درجة مئوية للتغلب على طرد الجرعة الدوائية. تعتمد المستحلبات النانوية على كريموفور اي ال وترانسكيوتول  كنظام استحلاب لتثبيت زيت عشبة الليمون المحمل بالإيدبينون. تم استخدام طريقة الاستحلاب التلقائي لتحضير المستحلبات النانوية التي تميزت بمقياس زيتا بينما تم تحضير الهلاميات المائية الحساسة للحرارة باستخدام الطريقة الباردة. تم إجراء اختبار الذوبان في المختبر ودراسة التخلل خارج الجسم الحي من خلال الغشاء المخاطي للأنف للأغنام لتقييم نسبة التخلل المعززة ومعدل التخلل ومعامل التخلل. تمت دراسة التأثير النسيجي المرضي للتطبيق المباشر على الغشاء المخاطي للأنف في الأغنام باستخدام المجهر الضوئي لتقييم السمية الخلوية
. النتائج: أظهرت الصيغة المحضرة من NE1 مع بولوكسامير 407: بولوكسامير 188 بتركيزات 10:3% وزن/وزن على التوالي، إطلاقاً كاملاً للدواء خلال 120 دقيقة بسبب التآكل الكامل لخليط البوليمرات. علاوة على ذلك، تم الحصول على مستحلب نانو حساس للحرارة عند درجة حرارة الجيل 31.8 درجة مئوية بتركيزات أقل بكثير من بولوكسامير 407 (10٪) مقارنة بالدراسات السابقة. احتفظت المستحلبات النانوية بحجمها الكروي أقل من 100 نانومتر بسبب زيادة تثبيت  الهلام بطريقة الانحباس
. الاستنتاجات أدى تغلغل الدواء من خلال الغشاء المخاطي للأنف في الأغنام إلى زيادة في نسبة التخلل المعزز إلى 20.3 مرة وغيرها من المعلمات الحركية للتدفق مقارنة بتلك الخاصة بتشتت زيت IDB. أظهرت السمية الخلوية المباشرة استجابة التهابية بسيطة تتميز بالتسلل المصلي للخلايا الالتهابية والوذمة. في المقابل، احتفظت معظم الخلايا الظهارية بخصائصها النسيجية مقارنة بشرائح التحكم
Precision Medicine Approach to Alzheimer’s Disease: Rationale and Implications
Authors: Bredesen Dale E. , Toups Kat , Hathaway Ann , Gordon Deborah , Chung Henrianna , Raji Cyrus , Boyd Alan , Hill Benjamin D. , Hausman-Cohen Sharon , Attarha Mouna , Chwa Won Jong , Kurakin Alexei , Jarrett Michael
Published: October 2023

The neurodegenerative disease field has enjoyed extremely limited success in the development of effective therapeutics. One potential reason is the lack of disease models that yield accurate predictions and optimal therapeutic targets. Standard clinical trials have pre-determined a single treatment modality, which may be unrelated to the primary drivers of neurodegeneration. Recent proof-of-concept clinical trials using a precision medicine approach suggest a new model of Alzheimer’s disease (AD) as a chronic innate encephalitis that creates a network insufficiency. Identifying and addressing the multiple potential contributors to cognitive decline for each patient may represent a more effective strategy. Here we review the rationale for a precision medicine approach in prevention and treatment of cognitive decline associated with AD. Results and implications from recent proof-of-concept clinical trials are presented. Randomized controlled trials, with much larger patient numbers, are likely to be significant to establishing precision medicine protocols as a standard of care for prevention and treatment of cognitive decline. Furthermore, combining this approach with the pharmaceutical approach offers the potential for enhanced outcomes. However, incorporating precision medicine approaches into everyday evaluation and care, as well as future clinical trials, would require fundamental changes in trial design, IRB considerations, funding considerations, laboratory evaluation, personalized treatment plans, treatment teams, and ultimately in reimbursement guidelines. Nonetheless, precision medicine approaches to AD, based on a novel model of AD pathophysiology, offer promise that has not been realized to date with monotherapeutic approaches.
The Underestimated Relevance of Alzheimer’s Disease Copathology in Amyotrophic Lateral Sclerosis
Authors: Barba Lorenzo , Otto Markus , Abu-Rumeileh Samir
Published: October 2023

Concomitant Alzheimer’s disease (AD) pathology can be observed in approximately 10–15% of cases with amyotrophic lateral sclerosis (ALS). ALS-AD patients have a higher prevalence of amnestic cognitive disturbances, which may often precede motor symptoms. Cerebrospinal fluid (CSF) AD core biomarkers usually show no or slightly significant changes in ALS, whereas blood phosphorylated tau protein might be increased independently from AD copathology. Neurofilament proteins are consistently elevated in CSF and blood of ALS, but have been poorly investigated in ALS-AD. All these issues should be taken into account when using fluid biomarkers as inclusion criteria or secondary endpoints in clinical trials.
A novel multi-parameter similarity measure of interval neutrosophic sets for medical diagnosis
Authors: Ji Bin , Zhou Chuhao , Chen Ze , Zheng Shuai
Published: October 2023

The use of similarity measures in interval-valued neutrosophic sets (IVNSs) theory is essential for comparing and assessing the degree of IVNSs difference. However, existing similarity measures for IVNSs suffer from several issues such as lacking precise axiomatic definitions, counterintuitive results, division by zero errors, inability to distinguish between positive and negative differences, and failure to satisfy the ranking definition. To address these limitations, we propose a novel multi-parameter similarity measure for IVNSs based on the tangent function. We demonstrate that our measure satisfies the axiomatic definition and apply it to medical diagnosis, achieving accurate diagnostic results. Additionally, we consider the interactions between symptoms, adjust the proposed similarity measure using Choquet integrals, and provide analytical comparisons to demonstrate the advantages of our improved similarity measure, highlighting its stability and high confidence in the field of medical diagnosis.This study contributes to the advancement of similarity measures in IVNSs theory and provides valuable insights for the field of medical diagnosis.
AdaTrans: An adaptive transformer for IoT Malware detection based on sensitive API call graph and inter-component communication analysis
Authors: Pi Feng , Tian Shengwei , Pei Xinjun , Chen Peng , Wang Xin , Wang Xiaowei
Published: October 2023

With the development of the Internet of Things (IoT), mobile devices are playing an increasingly important role in our daily lives. There are various malware threats present in these mobile devices, which can steal users’ personal information. Some malware exploits Inter-Component Communication (ICC) to execute malicious activities for unauthorized data access and system control, enabling communication between different components within an app and between different apps. In this paper, we propose an Adaptive Transformer-based malware framework (named AdaTrans) that combines sensitive Application Programming Interface (API)- and ICC-related features. The framework first extracts sensitive function call subgraphs (SFCS) to reflect the caller-callee relationships, and then utilizes ICC interactions to reveal hidden communication patterns in malicious activities. Moreover, we propose a novel adaptive Transformer model to detect malicious behaviors. We evaluate our framework on real-world datasets and demonstrate that AdaTrans consistently outperforms other existing state-of-the-art systems.
Carpal tunnel syndrome severity, hand discomfort, and usability among three types of computer mouse
Authors: Oveisi Elahe , Khanlari Payam , Ebrahimzadeh-Afrouzi Mahdi
Published: October 2023

BACKGROUND: Numerous people use computer mice for long hours, especially in offices. Mouse users reported various pains and discomfort. OBJECTIVE: The study aimed to assess three types of most common mice (vertical, traditional, flat) in Iran in terms of their effects on carpal tunnel syndrome, hand discomfort, and usability. METHODS: The Boston Carpal Tunnel Syndrome questionnaire, the Cornell Hand Discomfort Questionnaire (CHDQ), System Usability Scale (SUS), and Workplace Ergonomic Risk Assessment (WERA) scores were used to assess vertical, traditional, and flat mice. In addition, the participant’s hand position was analyzed by observation method. RESULTS: Most participants had medium carpal tunnel syndrome severity; however, flat mouse users had a higher score, and the difference between mice was insignificant (p > 0.05). Most mouse users felt discomfort in their small and ring fingers, and the type of mouse significantly affected thumb discomfort level. More flat users felt Pain in the different parts of their hands. The flat mouse has the least SUS score. There was a significant difference between the three mice regarding SUS scores (p < 0.05). WERA mean values were acceptable for numerous mice. Adopting neutral wrist postures was more common among vertical, flat, and traditional mouse users, respectively; however, the flat mouse users tended to bend their fingers. CONCLUSION: There are differences between vertical and traditional flat mice in terms of ergonomic indicators. Although more studies are needed, it seems that vertical mice are better in some indicators.
Validation of a temperature-humidity index (Humidex) in evaluating heat stress at a tile factory in Iran
Authors: Barzegar Akbar , Pouya Amin Babaei , Hashemian Amir Hossein , Nadri Farshad , Poursadeqiyan Mohsen , Omidian Ali
Published: October 2023

BACKGROUND: Several heat indices have been developed in industrial health, but each has its limitations. OBJECTIVE: The objective of this article is to determine the validity and applicability of a temperature-humidity index, named Humidex compared with the Standard Wet-Bulb Globe Temperature (WBGT) index (ISO 7243). METHOD: This cross-sectional study was conducted in the summer of 2019, in a tile factory in the west of Iran. 59 measurements were performed in 8 different workstations. Environmental parameters including natural wet bulb temperature (Tnw), dry bulb temperature (Ta), globe bulb temperature (Tg), and heat stress (WBGT) were measured. Humidex was calculated according to an equation. SPSS software (version 16) was used for data analysis. RESULTS: There was a high correlation between Humidex and WBGT in the estimation of heat stress (R=0.912, P<0.001). The Kappa Coefficient between Humidex and WBGT was 0.298, P=0.001. CONCLUSION: Humidex is highly correlated with WBGT. Humidex can be used instead of the WBGT index, especially in hot and humid environments.
Hybrid multi-criteria decision making approach proposal for evaluating workloads of aircraft maintenance technicians
Authors: Öztürk Yaşar , Yazgan Ebru , Delice Elif Kılıç
Published: October 2023

BACKGROUND: Aircraft maintenance technicians (AMTs) have the most difficulty in terms of total workload criteria working in line maintenance. This is a very important problem for the Aircraft Maintenance Organization. A systematic and scientific approach is required for its solution. OBJECTIVE: This study proposes a new Multi-Criteria Decision Making (MCDM) based approach to evaluating the total workloads of AMTs to identify the most challenging AMT tasks in the aircraft maintenance organization. METHODS: A new hybrid MCDM approach is proposed by integrating the Decision-Making Trial and Evaluation Laboratory (DEMATEL) and Technique for Order Preference by Similarity (TOPSIS) methods to compare AMTs on the basis of workloads according to license categories. The hybrid method proposed in this study evaluates the total workload under three main titles: mental, physical, and environmental workload. RESULTS: Focusing on AMTs working in line maintenance of an aircraft maintenance organization, this study revealed that the most important workload criteria determined by the DEMATEL method are lower back strain, upper back strain, time pressure, and air temperature criteria. The results of the TOPSIS method showed that the license categories of AMTs are sorted according to the workloads as follows: A, B2, B1, and B1 + B2. The AMTs holding a “Category A” license have fewer workloads than the other categories. CONCLUSION: The findings of the study reveal some measures that might allow authorities to minimize the workload of AMTs. In addition, the study contributes to the literature because there are few studies that systematically analyze total workloads by using MCDM methods.
The engagement chasm: Time for competency-based training in employee engagement for healthcare and beyond
Authors: Hassan Imad Salah , Elamin Mohammed Elfatih Mohammed , Awad Ahmed Hani Mubarak , Abdelgadir Mukhtar Mohamedsalih Mukhtar , Ahmed Mustafa Awadalla Ibrahim , Ayyad Fatima Abdalrahman Adam Ali , Salih Khadija Bushra Salim , Ishag Rayan Mohammed Abdullah
Published: October 2023

BACKGROUND: Employee disengagement in healthcare and business is currently at unexceptionally high levels worldwide. Disengagement negatively impacts productivity, profitability, efficiency (waste reduction), innovation, quality, customer satisfaction and experience, staff well-being, safety, mortality, staff attendance, and turnover. Despite its serious detrimental impacts, no dedicated competency-based training curriculum exists for engagement as a competency. OBJECTIVE: To develop a competency-based educational curriculum for an Engagement Competency. METHODS: A curricular roadmap comprising the following steps was observed 1. Identifying the desired outcomes needed of trainees. These must help fulfill all the Q12 Gallup survey engagement items. 2. Explicitly defining the required Competencies, Entrustable Professional Activities, and Milestones, 3. Selecting the educational activities, and instructional methods, 4. Selecting the tools to assess progress along the milestones, and finally, 5. Designing an evaluation system to assess the outcomes of the engagement competency program. RESULTS: We developed an Engagement Competency Framework with 7 Entrustable Professional activities “rationally and practically” arranged. These are: Envision E1, Embrace E2, Empower E3, Enlighten E4, Empathize E5, Energize E6, and Evaluate E7 (the 7Es). CONCLUSION: The unfortunate global issue of disengagement in healthcare and in the business arena may be practically tackled by introducing Engagement Competency and training. It should be compulsory for all in the “leadership role". Such training may lead to remarkable performance improvement and a happier, more prosperous, and safer world.
Bilateral adrenal pathology: Conn syndrome and autonomous cortisol secretion
Authors: Hradova Diana , Yuzvenko Violetta
Published: October 2023

this case report presents the route of a patient with bilateral adrenal pathology and severe complaints, who where admitted to the Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of MoH of Ukraine as scheduled. The selective blood sampling from adrenal veins, which was performed at the Center, in patient with bilateral adrenal pathology, is analyzed. This method is the gold standard of diagnosis, which allows to choose the optimal method of treatment for such patients.
Diagnostic and treatment model of post-intubation injuries of the trachea
Authors: Sadovyi Valentyn , Kuchyn Iurii , Bielka Kateryna , Sazhyn Dmytro
Published: October 2023

in medical practice, iatrogenic injuries caused by drugs or medical procedures are considered the most undesirable, as they are usually considered as intentional damage to the patient's health by the doctor. It is also impossible not to pay attention to the fact that such cases do not always have a favorable outcome. All this creates grounds for incorrect coverage of one's own record of failures and mistakes by specialists. The aim of the work was to study the available scientific data regarding iatrogenic post-intubation tracheal injuries and to form a diagnostic and treatment model of post-intubation tracheal injuries. Scientific articles, literature reviews and clinical cases of domestic and foreign authors related to iatrogenic injuries of the trachea are analyzed in the work. Most of the studied sources were not published later than 2018. Post-intubation tracheal ruptures are a rare but serious complication of intubation or tracheostomy. Mechanical and anatomical factors are among the risk factors of these complications. Most of them can be avoided by following the rules and recommendations when intubating patients. The main standards in the diagnosis of iatrogenic injuries of the trachea are X-ray and endoscopic evaluation, which allow detecting and characterizing suspected injuries. The use of the proposed medical-diagnostic model for assessing the severity of the condition of a patient with a tracheal injury can speed up diagnostic searches and help determine the therapeutic tactics of managing patient data. Treatment of post-intubation injuries can be conditionally divided into conservative, endoscopic and surgical. Separately, it is desirable to note the tactics of endoscopic stenting, which is becoming a viable alternative to surgical intervention, and not a backup option. The world's routine approach to the problem of post-intubation complications obviously only adds to the difficulties in the prevention and management of such patients. By themselves, such complications are not very frequent, but still remain extremely threatening and can lead to fatal consequences. And, unfortunately, insufficient discussion of such cases makes it difficult to develop algorithms for managing such patients. The proposed model of diagnosis and management of patients aims to improve the quality of treatment of such patients and reduce the number of possible complications.
Experimental Comparison of Interference and Autocollimating Null Indicators
Authors: Nyamweru B. , Shishalova E. V.
Published: October 2023

Introduction. At present, measurement of angles with high accuracy is an essential task in various scientific and industrial fields. The goniometer is one of the most widespread high-precision angle measuring devices, which can incorporate various types of null indicators. In turn, null indicators (NI) are based on different operating principles and can be sensitive to external factors that contribute to the measurement error.

Aim. Experimental comparison of two NI types: an interference NI with a Koester prism and an autocollimating NI based on a quadrant photodiode.

Materials and methods. An experimental setup was assembled, including two NI that could be connected to one goniometer and measure the accumulated angles of one optical polygon under the same conditions.

Results. As a result of conducting measurements and performing a cross-calibration procedure, four sets of data were obtained. An analysis of the processed data showed that the difference in the errors of the ring laser when using two NI did not exceed 0.06 arc seconds, being within the margin of random error. At the same time, the difference between the deviations of the reflecting faces from the nominal position for the two faces exceeded this limit, which confirms the effect of deviation of the surface from the plane on angular measurements with different types of null indicators.

Conclusion. According to the results obtained, from the random error point of view, the interference null indicator NI showed higher performance, demonstrating the RMS of measured values of 0.02 angular seconds when measured during 25 prism revolutions. At the same time, the autocollimating null indicator NI had an RMS at the level of 0.04 angular seconds when measured during 64 revolutions. Presumably, this may be caused by the installation specifics of NI. It should also be noted that there is no correlation between the statistical characteristics of the reflecting face itself and the difference between its deviations determined by different NI types.
Pituitary Metastasis Clinical Presentation of Diabetes Insipidus Six Years after Invasive Breast Carcinoma Diagnosis: Case Report
Authors: Mehanna Samya Hamad , Linhares Julia Costa , Santos Emily Karoline Araujo Nonato Dos , Cavalcanti Teresa Cristina
Published: October 2023

Introduction: Breast carcinomas are the major cause of death in women with cancer worldwide, mainly in metastatic cases. The pituitary gland stands for only 6-8% of the secondary sites of distant metastasis and it is usually asymptomatic. When symptomatic, these lesions can mimic primary pituitary diseases. Case report: A 43-year-old woman underwent a left mastectomy with axillary lymph node dissection in April 2013 due to a luminal, invasive ductal carcinoma with nodal metastasis. Six years later, she started complaining of myalgia, bone pain, dizziness and decreased visual acuity, in addition to polydipsia and polyuria. Laboratory tests showed hyperprolactinemia and diabetes insipidus suggestive of panhypopituitarism. Magnetic resonance imaging of the brain showed a sellar tumor with extension to adjacent structures which was removed on November 2019. A pathology report of an epithelial neoplasm of unknown origin and an immunohistochemical study showed positivity for estrogen, progesterone receptors and GATA 3, and negativity for pituitary hormones. This set of findings and the histological morphology were consistent with a metastatic mucinous adenocarcinoma of mammary origin without HER-2 overexpression. The patient underwent ovarian ablation, central nervous system radiotherapy, chemotherapy and oncological follow-up. Conclusion: The patient's young age and clinical presentation of visual impairment and sudden development of diabetes insipidus diverges from the current data, since these findings are usually present in asymptomatic women over sixty-years-old. The varied clinical presentation can lead to a delay in diagnosis of pituitary metastasis, which reinforces the importance of reporting cases like this.
Caracterização de Pacientes com Câncer de Mama e Critérios da National Comprehensive Cancer Network para Realização do Teste Genético BRCA1 e BRCA2
Authors: Seewald Rafael Armando , Silva André Anjos da , Silva Guilherme Liberato da , Maciel Álvaro Ortigara , Mascarello Fernando Mateus , Follmann Natália Lenz , Laste Gabriela
Published: October 2023

Introdução: Aproximadamente 10% dos casos de câncer de mama são atribuíveis a mutações germinativas em genes de suscetibilidade, incluindo BRCA1 e BRCA2. A National Comprehensive Cancer Network (NCCN) recomenda a triagem de mulheres com câncer de mama para mutações em BRCA1/2 em cenários definidos. No entanto, esses testes genéticos não estão disponíveis no Sistema Único de Saúde (SUS). Objetivo: Caracterizar as mulheres com câncer de mama e definir os critérios para realização do teste BRCA1/2. Método: Estudo quantitativo, descritivo, analítico e retrospectivo. Foram analisados ​​prontuários de mulheres com diagnóstico de câncer de mama pelo SUS entre janeiro de 2016 e dezembro de 2018, por meio do software JAMOVI (versão 2.3 - 2022). Resultados: Foram diagnosticadas 245 mulheres. De acordo com as diretrizes da NCCN, 97 mulheres atenderam aos critérios para realizar o teste BRCA1/2, com idade média de 47 anos, predominantemente brancas (90,7%), com comorbidades (55,6%), na pré-menopausa (59,8%), diagnosticadas nos estágios iniciais 0 - IIb (68, 2%), e 48,4% tinham histórico familiar de câncer de mama. A histologia e o subtipo molecular mais frequentes foram carcinoma ductal invasivo (87,2%) e tipo luminal (59,8%). Conclusão: Considerando os critérios da NCCN, um número significativo de mulheres diagnosticadas pelo SUS teve indicação para realização do teste BRCA1/2. Essas mulheres são mais jovens, têm menos comorbidades, estão em período pré-menopausa mais frequentemente e diferem quanto ao subtipo molecular quando comparadas àquelas sem indicação de realização do exame.
Profile and characteristic of laryngeal cancer in Radiotherapy Department of Hasan Sadikin General Hospital
Authors: Pinakaratna Afifah , Utama Marhendra Satria , Permana Agung Dinasti
Published: October 2023

Background: A laryngeal cancer diagnosis is often in the advanced stage, while the screening has not much done at this time. Studies on laryngeal cancer that uses radiotherapy are also still difficult to find, especially in Indonesia. Purposes: This study aimed to describe patients' profiles with laryngeal cancer who received radiotherapy treatment in the 2018 to 2019 period. Methods: This research was a descriptive quantitative with a cross-sectional study conducted at Radiotherapy Department, Hasan Sadikin General Hospital. Results: The patient's medical record was collected, and 38 patients with laryngeal cancer were found. Most of the patients are male (86,8%), ranging from age 51-60 (55,3%), work as staff office/traders (21,1%), and have a smoking history (52%). The chief complaint is often in the form of hoarseness (76,3%), the location of the cancer is No Other Specified (31,6%), most of the cells were squamous cell carcinoma (86,8%), and the stage was mainly in stage IV (60,5%). Surgery with radiotherapy is the most common management (50%), and surgery that is commonly used is total laryngectomy (36,8%). Some patients also have a tracheostomy before management (36,8%). Radiotherapy is more often for adjuvant purposes (52,6%). Conclusions: Laryngeal cancer is still uncommon, but we need to increase awareness and screening because of the advanced stage that more commonly occurs.
Comparison between Eustachian tube angle and length in chronic otitis media and contralateral ear
Authors: Erlangga Eggi , Wahyudiono Ahmad Dian , Yueniwati Yuyun , Setijowati Nanik
Published: October 2023

Background: Chronic suppurative otitis media (CSOM) is still a significant public health problem, especially in developing countries. Eustachian tube dysfunction is one of the factors that influence the occurrence of CSOM. The pathogenesis of acute and chronic otitis media is initiated by negative pressure in the middle ear. One theory of the event of CSOM is the continuum theory. The eustachian tube as one of the factors that influence the occurrence of CSOM has been proven from various studies comparing CSOM patients and the average population and CSOM with and without cholesteatoma. With the advanced technology, CT scan helps diagnose pathological conditions in the ear as a diagnostic tool and evaluation modality. CT scan imaging with a multiplanar reconstruction technique can provide a clear image of the anatomical shape of the Eustachian tube. Objective: This study aims to determine the relationship between the angle and length of the Eustachian tube in the ear with CSOM and the contralateral ear's angle and length. Method: An analytic study with a cross-sectional design involving 30 samples of CSOM patients with the contralateral ear. The measurement of the angle and length of the Eustachian tube using the multiplanar HRCT temporal reconstruction technique. Result: Statistical analysis with paired t-test showed that the Eustachian tube angle was significantly more horizontal in the CSOM ear than the contralateral ear (p<0.05). Eustachian tube length was shorter in CSOM than contralateral (p<0.05). Conclusion: The angle of the eustachian tube in the CSOM ear is smaller (more horizontal) and shorter than the contralateral ear.
Validity and reliability of Eustachian Tube Dysfunction Questionnaire (ETDQ-7) adaptation in Bahasa Indonesia
Authors: Restuti Ratna Dwi , Sriyana Ayu Astria , Priyono Harim , Saleh Rangga Rayendra , Alviandi Widayat
Published: October 2023

Background: Eustachian tube dysfunction occurred in 0.9% of world’s population. An instrument called Eustachian Tube Dysfunction Questionnaire (ETDQ-7) in English Language was developed as a scoring system to evaluate patients’ problems for the past month with 100% sensitivity and specificity value (p<0.001). This questionnaire is proven useful internationally to evaluate patients’ complaints, disease course and to determine the therapeutic outcome. However, Indonesia has not had the adapted version of ETDQ-7. Purpose: To evaluate the validity and reliability of ETDQ-7 adapted to Bahasa Indonesia. Method: This was a descriptive cross-sectional study on 31 adult subjects whose primary language were Indonesian. Subjects were required to fill the questionnaire that went through cross-cultural adaptation. The data was analyzed using Spearman coefficient correlation for validity and Cronbach-α score for reliability. Result: The results showed that each ETDQ-7 question were significantly correlated to the total score of ETDQ-7 (p<0.05) with r value ranging from 0.568-0.790 and Cronbach-α value is 0.801. Conclusion: ETDQ-7 adapted to Bahasa Indonesia was a valid and reliable questionnaire to determine disease progression in patients with Eustachian tube dysfunction whose primary language are Indonesian.

Keyword: ETDQ-7, validity, reliability, Bahasa Indonesia
Animal Medicine in Medical Practice in Batak Toba Tribe
Authors: Vicky Rifai Adriansyah1  , Sri Alem Br Sembiring  , Rutmika L Simanullang  , Hagata Fikasani  , Desi Melince Purba  , Rachel Meilisa Angelina Nadeak  , Bella Selvia Hutabarat  , Wahyu Kurniawan
Published: October 2023

This article explains how traditional medicine, especially those that use animals in traditional medicine facilities of the Batak tribe, Animal medicine is a medical practice carried out by means of animals as mediators or as herbs for consumption in curing infectious diseases. Diseases that can be cured by the use of this animal also vary from naturalistic diseases such as typhus, toothache, and ulcers to diseases such as gadam. This paper focuses on the Toba Batak tribe with data collection techniques in the form of primary data in the form of interviews and also through direct experience of the author and secondary data in the form of literature reviews by reviewing written writings from online databases. Research was conducted on Batak people and the slap animals that are often used for treatment. From the results of research, it is known that, until now, these treatment activities still exist despite modern medicine.