bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Slag‐Metal Emulsion and Its Impact on Foaming Behavior and Slopping in the LD Process
Authors: Brämming Mats , Engström Fredrik , Samuelsson Caisa , Björkman Bo
Published: December 2018

In the Basic Oxygen Steelmaking (BOS) process, a heterogeneous emulsion‐solid mix will form, consisting of an emulsion of liquid slag and metal droplets, in which 2nd phase particles of undissolved fluxes and solid in‐blow precipitates are suspended. When the carbon in the metal droplets reacts with iron oxide, small bubbles of CO gas are formed. If the upward movement of these bubbles is obstructed by the physical properties of the emulsion‐solid mix, foaming will occur. Certain process conditions may lead to an excessive foam growth, in the worst case forcing foam out of the vessel. This undesired process event is known as “slopping”. Extensive studies during recent decades have shown that emulsion characteristics strongly connected to foaming are: viscosity, surface tension, and density. The extent of foaming is also dependent on bubble size; foaming increasing with smaller bubble size. However, investigations into the influence of the mineralogy and morphology of the emulsion‐solid mix on foaming in basic oxygen steelmaking are scarce. In this work, samples from trials in a 6‐tonne pilot plant BOS vessel are examined by XRD and with SEM for the determination of emulsion‐solid mix mineralogy and morphology at different stages of the oxygen blow. The study confirms the importance of tight process control in order to minimize the emulsion‐solid mix apparent viscosity and, hence, the foam height, but this without over‐oxidizing the liquid slag phase, which would result in increased gas generation within the slag‐metal emulsion.
Core outcome set for research studies evaluating treatments for twin–twin transfusion syndrome
Authors: Perry H. , Duffy J. M. N. , Reed K. , Baschat A. , Deprest J. , Hecher K. , Lewi L. , Lopriore E. , Oepkes D. , Khalil A. ,   the International Collaboration to Harmonise Outcomes for Twin–Twin Transfusion Syndrome (CHOOSE)
Published: December 2018

Objective

To develop, using a Delphi procedure and a nominal group technique, a core outcome set (COS) for studies evaluating treatments for twin–twin transfusion syndrome (TTTS), which should assist in standardizing outcome selection, collection and reporting in future research studies.

Methods

An international steering group comprising healthcare professionals, researchers and patients with experience of TTTS guided the development of this COS. Potential core outcomes, identified through a comprehensive literature review and supplemented by outcomes suggested by the steering group, were entered into a three‐round Delphi survey. Healthcare professionals, researchers, and patients or relatives of patients who had experienced TTTS were invited to participate. Consensus was defined a priori using the 15%/70% definition of the Core Outcome Measures in Effectiveness Trials (COMET) initiative. The modified nominal group technique was used to evaluate the consensus outcomes in a face‐to‐face consultation meeting and identify the final COS.

Results

One hundred and three participants, from 29 countries, participated in the three‐round Delphi survey. Of those, 88 completed all three rounds. Twenty‐two consensus outcomes were identified through the Delphi procedure and entered into the modified nominal group technique. The consensus meeting was attended by 11 healthcare professionals, two researchers and three patients; 12 core outcomes were prioritized for inclusion in the COS. Fetal core outcomes included live birth, pregnancy loss (including miscarriage, stillbirth, termination of pregnancy and neonatal mortality), subsequent death of a cotwin following single‐twin demise at the time of treatment, recurrence of TTTS, twin anemia–polycythemia sequence and amniotic band syndrome. Neonatal core outcomes included gestational age at delivery, birth weight, brain injury syndromes and ischemic limb injury. Maternal core outcomes included maternal mortality and admission to Level‐2 or ‐3 care setting. One aspirational outcome, neurodevelopment at 18–24 months of age, was also prioritized.

Conclusions

Implementing the COS for TTTS within future research studies could make a substantial contribution to advancing the usefulness of research in TTTS. Standardized definitions and measurement instruments are now required for individual core outcomes. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
A framework for isogeometric‐analysis‐based optimization of wind turbine blade structures
Authors: Herrema Austin J. , Kiendl Josef , Hsu Ming‐Chen
Published: December 2018

Early‐stage wind turbine blade design usually relies heavily on low‐fidelity structural models; high‐fidelity, finite‐element‐based structural analyses are reserved for later design stages because of their complex workflows and high computational expense. Yet, high‐fidelity structural analyses often provide design‐governing feedback such as buckling load factors. Mitigation of the issues of workflow complexity and computational expense would allow designers to utilize high‐fidelity feedback earlier, more easily, and more often in the design process. Thus, a blade analysis framework that employs isogeometric analysis (IGA), a simulation method that overcomes many of the aforementioned drawbacks associated with traditional finite element analysis (FEA), is presented. IGA directly utilizes the mathematical models generated by computer‐aided design (CAD) software, requiring less user interaction and no conversion of parametric geometries to finite element meshes. Furthermore, IGA tends to have superior per‐degree‐of‐freedom accuracy compared with traditional FEA. Issues unique to IGA in the context of wind turbine blade design, such as coupling of thin‐shell components, are addressed, and a design approach that combines reduced‐order aeroelastic analysis with IGA is outlined. Aeroelastic analysis is used to efficiently provide dynamic kinematic data for a wide range of wind load cases, while IGA is used to perform buckling analysis. The value of incorporating high‐fidelity analysis feedback into blade design is demonstrated through optimization of the NREL/SNL 5 MW wind turbine blade. A variety of potential designs are produced with reduced blade mass and material cost, and IGA‐based buckling analysis is shown to provide design‐governing constraint information.
Global and regional climate in 2017
Authors: Kennedy John J. , Dunn Robert J. H. , Titchner Holly A. , Morice Colin P. , Killick Rachel E. , McCarthy Mark P.
Published: December 2018

Globally, 2017 was one of the three warmest years on record at the surface of the Earth, despite neutral or weak La Niña conditions. Warmth was widespread in the climate system, with ocean heat and atmospheric temperatures also among the top three years. Arctic and Antarctic sea ice extents were below the long‐term average, and a number of months had record low extents. In the UK and Europe there were a number of unusual weather events, and high spring and summer temperatures affected areas of Europe, North Africa and the Middle East.
Preoperative High‐Resolution Manometry Criteria are Associated with Dysphagia After Nissen Fundoplication
Authors: Siegal Steve R. , Dunst Christy M. , Robinson Ben , Dewey Elizabeth N. , Swanstrom Lee L. , DeMeester Steven R.
Published: December 2018

Background

Dysphagia after Nissen fundoplication is challenging for patients. High‐resolution manometry (HRM) has rarely been studied preoperatively to determine whether manometry values correlated with postoperative dysphagia after fundoplication. We aim to determine whether HRM criteria could predict dysphagia after Nissen fundoplication.

Methods

A retrospective review of single‐institution laparoscopic Nissen fundoplications (LNF) from 2013 to 2015 was completed. Dysphagia was graded using a standard scale. Four groups were: those with new postoperative dysphagia (ND), never had dysphagia (NV), continued dysphagia (CD), and resolved dysphagia (RD). Manometry criteria included distal contractile integral (DCI), contraction front velocity (CFV), distal latency (DL), integrated relaxation pressure (IRP), percent peristalsis (PP), and distal esophageal contraction amplitude (DECA). Statistical bootstrapping was used to power sample sizes for ANOVA analysis.

Results

Ninety‐four patients were included in the original cohort. Statistical bootstrapping sample size was 2992 patients. Among patients who did not have dysphagia prior to LNF, no HRM metric was associated with developing new dysphagia. Among those with dysphagia prior to LNF, a higher DCI, CFV, DL, PP, and DECA were associated with resolution of dysphagia. The RD group was 2.77 times more likely to have a DCI ≥ 1000 mmHg‐s‐cm compared with the CD group.

Conclusions

HRM criteria could not predict the development of postoperative dysphagia. However, in those with preoperative dysphagia and strong manometry criteria, dysphagia is more likely to resolve after Nissen fundoplication. Meanwhile, in those with preoperative dysphagia and weak manometry, dysphagia may persist and these patients may be better served with a partial fundoplication.
Initial growth dynamics of 10 nm nanobubbles in the graphene liquid cell
Authors: Kim QHwan , Shin Dongha , Park Jungwon , Weitz David A. , Jhe Wonho
Published: December 2018

The unexpected long lifetime of nanobubble against the large Laplace pressure is one of the important issues in nanobubble research and a few models have been proposed to explain it. Most studies, however, have been focused on the observation of relatively large nanobubbles over 100 nm and are limited to the equilibrium state phenomena. The study on the sub-100 nm sized nanobubble is still lacking due to the limitation of imaging methods which overcomes the optical resolution limit. Here, we demonstrate the observation of growth dynamics of 10 nm nanobubbles confined in the graphene liquid cell using transmission electron microscopy (TEM). We modified the classical diffusion theory by considering the finite size of the confined system of graphene liquid cell (GLC), successfully describing the temporal growth of nanobubble. Our study shows that the growth of nanobubble is determined by the gas oversaturation, which is affected by the size of GLC.
Dictatorship, Monarchy, and Freedom of Expression in Thailand
Authors: Haberkorn Tyrell
Published: December 2018

On December 4, 2016, Jatupat Boonpattararaksa, known by his nickname “Pai,” then a law student at Khon Kaen University in northeastern Thailand, was arrested and accused of violating Article 112 of the Thai Criminal Code, or defaming, insulting, or threatening the king, queen, heir-apparent, or regent. Two days prior, he had shared to Facebook a biography of the new king, Maha Vajiralongkorn, or Rama X, who became king following the death of his father, Bhumipol Adulyadej, Rama IX, on October 13, 2016. The BBC Thai biography was candid and highlighted Vajiralongkorn's string of wives, his four abandoned sons, and his conferral of a military rank on his pet dog, as well as his recent bike rides for charity (BBC Thai 2016). Over 2,600 people shared the BBC Thai link, but Pai was the only person to be arrested in December 2016 and the only person to be prosecuted to date (TLHR 2017a). The complaint that led to Pai's arrest was filed by Lieutenant Colonel Phitakphon Chusri, a Khon Kaen–based soldier who has followed him closely.
Nonlinear velocity redistribution caused by energetic-particle-driven geodesic acoustic modes, mapped with the beam-plasma system
Authors: Biancalani A. , Carlevaro N. , Bottino A. , Montani G. , Qiu Z.
Published: December 2018

The nonlinear dynamics of energetic-particle (EP) driven geodesic acoustic modes (EGAM) in tokamaks is investigated, and compared with the beam-plasma system (BPS). The EGAM is studied with the global gyrokinetic (GK) particle-in-cell code ORB5, treating the thermal ions and EP (in this case, fast ions) as GK and neglecting the kinetic effects of the electrons. The wave–particle nonlinearity is only considered in the EGAM nonlinear dynamics. The BPS is studied with a one-dimensional code where the thermal plasma is treated as a linear dielectric, and the EP (in this case, fast electrons) with an N-body Hamiltonian formulation. A one-to-one mapping between the EGAM and the BPS is described. The focus is on understanding and predicting the EP redistribution in phase space. We identify here two distinct regimes for the mapping: in the low-drive regime, the BPS mapping with the EGAM is found to be complete, and in the high-drive regime, the EGAM dynamics and the BPS dynamics are found to differ. The transition is described with the presence of a non-negligible frequency chirping, which affects the EGAM but not the BPS, above the identified drive threshold. The difference can be resolved by adding an ad hoc frequency modification to the BPS model. As a main result, the formula for the prediction of the nonlinear width of the velocity redistribution around the resonance velocity is provided. This article is written as the second of a series of articles (the first being Biancalani et al. (J. Plasma Phys., vol. 83 (6), 2017, 725830602)) on the saturation of EGAMs due to wave–particle nonlinearity.
Filling biological information gaps of the marine topshell Phorcus sauciatus (Gastropoda: Trochidae) to ensure its sustainable exploitation
Authors: Sousa Ricardo , Vasconcelos Joana , Delgado João , Riera Rodrigo , González José A. , Freitas Mafalda , Henriques Paulo
Published: December 2018

Topshells play a pivotal role in intertidal rocky ecosystems and are adapted to harsh thermal and hydric stress. Phorcus sauciatus, a common grazer in the Macaronesian region (Madeira and the Canaries), has rarely been studied due to its restricted geographic distribution compared with Phorcus lineatus. Monthly samples were taken throughout 2017 to analyse biological parameters and evaluate the harvesting effect on the stocks of this species in Madeira. Individuals of the first age classes (<4 years) were dominant (~89%), while immature individuals were more abundant during the summer season. The spawning season occurs between March and August, especially from March to June. The size at first maturity was 12.95 mm long (1.68 years), with a continuous recruitment pattern throughout the year. Yield-per-recruit analysis (Y/R) showed that maximum production is achieved at a fishing mortality of 1.7 year−1, corresponding to a Y/R of 0.023 g. Currently, Phorcus sauciatus seems to be moderately exploited in Madeira, but urgent conservation measures, such as a landing obligation, the establishment of a minimum catch size of 15 mm length, and a closed season (February–May), are warranted to preserve stocks of this species in the medium to long term.
Dietrich Bonhoeffer and the necessity of kenosis for scriptural hermeneutics
Authors: Hamilton Nadine
Published: December 2018

It is the argument of this article that Dietrich Bonhoeffer's hermeneutical approach understands creaturely existence to be truly held by the Word made flesh as the risen Christ, who is still wholly human and therefore truly present in creation. Therefore, this article argues with Dietrich Bonhoeffer that, for a viable theological hermeneutics, it is critically necessary to consider the kenotic movement of the risen Christ, not only for a proper understanding of holy scripture in its genuine humanness, but also for an understanding of the new creation as taking place in reconciled creatures through the Word.
The eucharist in post-Reformation Scotland: a theological tale of harmony and diversity
Authors: Nimmo Paul T.
Published: December 2018

This essay explores the eucharistic theology of the confessions and catechisms in the Reformed tradition that were influential in Scotland between 1560 and 1640. A core purpose is to illumine the dogmatic architecture of early Reformed Scotland, and to reach a greater understanding of the different doctrinal impulses which shaped its churches and its people. A second purpose is to correct the way in which the doctrinal material from this period has been handled in some contemporary historic and constructive accounts. The essay first articulates a theological framework of harmony and diversity within which its source materials will be considered. It then exposits and analyses the content of these documents, aiming to locate them within this heuristic framework. In a final section, it draws some tentative conclusions in both historical and constructive directions.
THE TYPOLOGY AND TOPOGRAPHY OF SPARTAN BURIALS FROM THE PROTOGEOMETRIC TO THE HELLENISTIC PERIOD: RETHINKING SPARTAN EXCEPTIONALISM AND THE OSTENSIBLE CESSATION OF ADULT INTRAMURAL BURIALS IN THE GREEK WORLD
Authors: Christesen Paul
Published: December 2018

This article makes use of recently published graves to offer the first synthetic analysis of the typology and topography of Spartan burials that is founded on archaeological evidence. Our knowledge of Spartan burial practices has long been based almost entirely on textual sources – excavations conducted in Sparta between 1906 and 1994 uncovered fewer than 20 pre-Roman graves. The absence of pre-Roman cemeteries led scholars to conclude that, as long as the Lycurgan customs were in effect, all burials in Sparta were intracommunal and that few tombs had been found because they had been destroyed by later building activity. Burial practices have, as a result, been seen as one of many ways in which Sparta was an outlier. The aforementioned recently published graves offer a different picture of Spartan burial practices. It is now clear that there was at least one extracommunal cemetery in the Archaic, Classical and Hellenistic periods. What would normally be described as extramural burials did, therefore, take place, but intracommunal burials of adults continued to be made in Sparta throughout the Archaic, Classical and Hellenistic periods. Those burials were concentrated along important roads and on the slopes of hills. The emergent understanding of Spartan burial practices takes on added significance when placed in a wider context. Burial practices in Sparta align closely with those found in Argos and Corinth. Indeed, burial practices in Sparta, rather than being exceptional, are notably similar to those of its most important Peloponnesian neighbours; a key issue is that in all three poleis intracommunal burials continued to take place through the Hellenistic period. The finding that adults were buried both extracommunally and intracommunally in Sparta, Argos and Corinth after the Geometric period calls into question the standard narrative of the development of Greek burial practices in the post-Mycenaean period.
An Uncanny Honeymoon: Spanish Anarchism and the Bolshevik Dictatorship of the Proletariat, 1917–22
Authors: Zoffmann Rodriguez Arturo
Published: December 2018

The Russian Revolution became a beacon flare for anti-capitalists across the world, including many anarchists. The Spanish anarcho-syndicalists became ardent supporters of Bolshevism, and many endorsed the concept of the dictatorship of the proletariat. Here, I try to arrive at a political and historical understanding of this uncanny honeymoon, and question empirical explanations that present it as a simple misunderstanding. I firstly historicize the evolution of the concept of the workers’ dictatorship in the Spanish labor movement and assess it through the prism of the antagonism between the anarchists and socialists. I then set the reception of the Russian Revolution in the context of social ferment that emerged in Spain after 1917, which generated enormous enthusiasm and clouded theoretical differences. I finally relate the reception of the Soviet dictatorship to the intensification of class violence in these years, which rendered many anarchists hospitable to the authoritarian methods of the Bolsheviks.
Race and Class in the Postwar World: The Southern African Labour Congress
Authors: Money Duncan
Published: December 2018

Understandings of class have often been highly racialized and gendered. This article examines the efforts of white workers’ organizations in Southern Africa during the 1940s to forge such a class identity across the region and disseminate it among the international labor movement. For these organizations, the “real” working class was composed of white men who worked in mines, factories, and on the railways, something pertinent to contemporary understandings of class.

The focus of these efforts was the Southern African Labour Congress, which brought together white trade unions and labor parties and sought to secure a place for them in the postwar world. These organizations embodied the politics of “white laborism,” an ideology which fused political radicalism and white domination, and they enjoyed some success in gaining acceptance in the international labor movement. Although most labor histories of the region have adopted a national framework, this article offers an integrated regional labor history.
China's Missing Children: Political Barriers to Citizenship through the Household Registration System
Authors: Vortherms Samantha A.
Published: December 2018

Approximately 13 million Chinese lackhukou, the formal household registration. This prevents them from claiming full citizenship rights, including social welfare, formal identity documents and employment in the state sector. The government blames birth planning policies for the unregistered population, but this explanation ignores the role of internal migration. Because citizenship rights are locally determined and thehukousystem is locally managed, migrants face significant barriers to registering their children. This article systematically analyses the political determinants of the unregistered population nationwide. Based on a logit analysis of a sample of 2.5 million children from the 2000 census, I find that children born in violation of the one-child policy do have lower rates of registration and that children born to migrant mothers are four times more likely to be unregistered than registered. Continuing government focus on the effect of birth planning ignores the more fundamental institutional barriers inherent in thehukousystem.
Multivariate Constrained GNSS Real-time Full Attitude Determination Based on Attitude Domain Search
Authors: Wu Hongtao , Zhao Xiubin , Pang Chunlei , Zhang Liang , Feng Bo
Published: December 2018

A priori attitude information can improve the success rate and reliability of Global Navigation Satellite System (GNSS) multi-antennae attitude determination. However, a priori attitude information is nonlinear, and integrating a priori information into the objective function rigorously will increase the complexity of an ambiguity domain search, such as the Multivariate Constrained-Least-squares Ambiguity Decorrelation Adjustment (MC-LAMBDA) method. In this paper, a new method based on attitude domain search is presented to make use of the a priori attitude angle information with high efficiency. First, the a priori information of pitch and roll is integrated into the search process to derive the analytic search step for attitude angle, and the integer candidates are determined by traversal search in the three-dimensional attitude domain. Then, the objective function is parameterised with Euler angles, and a non-iterative approximate method is utilised to simplify the iterative computation in calculating objective function values. Experimental results reveal that compared to the MC-LAMBDA method, our new method has the same success rate and reliability, but higher efficiency in making use of a priori attitude information.
Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease
Authors: Akagawa Daisuke , Motoki Noriko , Hachiya Akira , Akazawa Yohei
Published: December 2018

Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited “supergiant” coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Intensive anticoagulant therapy combining heparin injections and high-dose warfarin was successful. The abnormal Q-waves and negative T-waves had completely disappeared 2 weeks later, likely in association with confirmed reperfusion. On the basis of prompt identification of abnormal Q-waves by electrocardiography, the patient could avoid thrombolytic therapy and catheter or surgical intervention.
A Match Made in Heaven? Southern Evangelicalism and the Rise and Fall of Agrarian Populism in the 1890s
Authors: Smångs Mattias , Redding Kent
Published: December 2018

The agrarian populist movement of the late nineteenth century remains among the largest social movement and third-party revolts in American history. It embodied a full-scale critique and mobilization against the inequities of the Gilded Age, and its influence stretched well into the Progressive and New Deal eras. While most accounts of the movement and party’s emergence and rapid demise have centered on economic conditions and interests, we link movement and third-party emergence and failure to the institutional arena second only to partisan politics in its impact on southern society at large, namely organized religion, particularly evangelical Protestantism. This article offers the first systematic analysis of the extent to which organized religion in the South channeled the mobilization of agrarian populism. The results both support and contradict the argument that agrarian populism was rooted in organized southern religion by suggesting that evangelical Protestantism channeled the mobilization of the Farmers’ Alliance movement but not the People’s Party. While white southern evangelical religion served as a potent cultural resource and mobilizing structure for the movement, the move to partisan politics helped create a disjuncture between movement and party from which Populism never recovered.
Der Einfluss eines achtsamkeitsbasierten Trainingsprogramms auf die Emotionsregulation von Sportlerinnen und Sportlern
Authors: Kittler Christoph , Gische Christian , Arnold Manuel , Jekauc Darko
Published: December 2018

Zusammenfassung. Diese Studie untersucht den Einfluss von Achtsamkeitstraining auf die Emotionsregulation von Sporttreibenden. In einem Prä-Post-Kontrollgruppendesign mit insgesamt 68 Versuchspersonen wurde getestet, ob ein Zusammenhang zwischen Achtsamkeit und dem Einsatz adaptiver (maladaptiver) Strategien der Emotionsregulation besteht. Das verwendete Programm (BATL, Berliner Achtsamkeitstraining zur Leistungsoptimierung) steigert die Achtsamkeit signifikant und nimmt dadurch einen indirekten Einfluss auf die Emotionsregulation von Sporttreibenden. Es wurde ein genereller, signifikanter Zusammenhang zwischen der Ausprägung von Achtsamkeit einer Person und deren Tendenz zum Einsatz maladaptiver Strategien gefunden. Je stärker Achtsamkeit bei einer Person ausgeprägt ist, desto seltener setzt diese maladaptive Strategien ein.
Erste Schritte zu Smartphone-basierten Sportinterventionen im Alltag?
Authors: Reichert Markus , Kapteinat Inga , Lauvai Isaia , Hennig Oliver , Reinhard Iris , Braun Urs , Limberger Matthias F. , Ebner-Priemer Ulrich W.
Published: December 2018

Zusammenfassung. Digitalisierung ermöglicht die vielversprechende Integration von Gesundheitsinterventionen in unseren Alltag, u.a. auf Smartphones, und bietet Chancen zur Implementierung von Bewegungsinterventionen, von denen auch insbesondere psychisch Erkrankte profitieren können. Allerdings ist die Kluft zwischen technisch bereits Umsetzbarem und Wissen um Wirkungen im Alltag groß. Beispielsweise wurde gezeigt, dass Sport generell Depressionssymptomen entgegenwirkt. Der spezifische Einfluss von Sportinterventionen auf die Alltags-Stimmung – einem der drei von Depressionen betroffenen Kernbereiche – ist jedoch unzureichend erforscht. Um diesen spezifischen Effekt zu untersuchen und den Weg zu evidenzbasierten Smartphoneinterventionen zu ebnen, statteten wir 15 depressive Personen jeweils drei Tage vor und nach einer zehnwöchigen Sportintervention mit Smartphone-Tagebüchern aus. Die Probanden beantworteten 83.6% aller Stimmungsabfragen. Signifikante Cross-Level-Interaktionen in Mehrebenen-Analysen bestätigten, dass Personen, die zu Interventionsbeginn weniger Sport trieben, größere Stimmungsverbesserungen nach der Intervention zeigten (Gute-Schlechte-Stimmung: b = 5.8; Ruhe-Unruhe: b = 5.3). Diese Pilotergebnisse sollen helfen, den vielversprechenden Weg zu evidenzbasierten sportpsychologischen Interventionen auf dem Smartphone zu ebnen.
The Spatial Variability of Organic Matter and Decomposition Processes at the Marsh Scale
Authors: Yousefi Lalimi F. , Silvestri S. , D'Alpaos A. , Roner M. , Marani M.
Published: December 2018

Accretion rate in salt marshes is governed by inorganic soil deposition and soil organic matter (SOM) accumulation. Existing (limited) observations and modeling results suggest that SOM amounts, biomass production, and decomposition processes should vary widely and systematically at the marsh scale. However, we lack observations aimed at understanding how SOM production is modulated spatially within a marsh, and at elucidating the relative importance of the controlling processes. The little existing data suggest that competing effects between biomass production and decomposition processes determine an approximately spatially constant contribution of SOM to total accretion. Here we investigate this idea using concurrent observations of SOM and decomposition rates from marshes in North Carolina. Our results indicate that systematic spatial variations in SOM are small, possibly as a result of an at least partial compensation of opposing trends in biomass production and decomposed organic matter. Our analyses show that deeper soil layers are, on average, characterized by lower decomposition rates and higher stabilization factors than shallower layers, likely because of differences in the persistence of water‐logged conditions. Overall, decomposition processes are sufficiently rapid that the labile material in the fresh biomass is completely decomposed before it can be sufficiently buried and stabilized. Our findings point to the importance of the fraction of initially refractory material and of stabilization processes in determining the final distribution of SOM within the soil column.
Factors Influencing the Seasonal Predictability of Northern Hemisphere Severe Winter Storms
Authors: Hansen F. , Kruschke T. , Greatbatch R. J. , Weisheimer A.
Published: December 2018

We investigate the role of the tropics, the stratosphere, and atmosphere‐ocean coupling for seasonal forecasts of strong, potentially damaging, Northern Hemisphere extratropical winter wind storm frequencies. This is done by means of relaxation experiments with the European Centre for Medium‐Range Weather Forecasts model, which allow us to prescribe perfect forecasts for specific parts of the coupled atmosphere‐ocean system. We find that perfect predictions of the Northern Hemisphere stratosphere significantly enhance winter storm predictive skill between eastern Greenland and Northern Europe. Correct seasonal predictions of the occurrence of stratospheric sudden warmings play a decisive role. The importance of correctly predicting the tropics and of two‐way atmosphere‐ocean coupling, both for forecasting stratospheric sudden warming risk and, correspondingly, severe winter storm frequency, is noted.
Observations of Zooplankton Diel Vertical Migration From High‐Resolution Surface Ocean Optical Measurements
Authors: Burt William J. , Tortell Philippe D.
Published: December 2018

We demonstrate that signal spikes in optical backscatter measurements provide information on the diel vertical migration patterns of oceanic zooplankton. During nighttime, we observed high frequency spikes in particulate optical backscatter coincident with increased acoustic backscatter from vertically migrating zooplankton. We used our measurements to examine the spatial patterns and daily timing of zooplankton migrations across the eastern Subarctic Pacific Ocean, demonstrating coherence of diel vertical migrations with regional hydrographic features. Vertical zooplankton migration was consistently observed in oligotrophic offshore waters but less apparent in higher productivity waters over the continental shelf, where bottom depth, hydrographic fronts, and plankton abundance influenced apparent zooplankton distributions. Our results suggest that spikes in optical backscatter data, which are normally removed during data processing, can be more fully exploited to examine marine zooplankton dynamics from autonomous measurement systems.
Mesoscale Eddies Modulate Mixed Layer Depth Globally
Authors: Gaube Peter , J. McGillicuddy Dennis , Moulin Aurélie J.
Published: December 2018

Mesoscale eddies, energetic vortices covering nearly a third of the ocean surface at any one time, modulate the spatial and temporal evolution of the mixed layer. We present a global analysis of concurrent satellite observations of mesoscale eddies with hydrographic profiles by autonomous Argo floats, revealing rich geographic and seasonal variability in the influence of eddies on mixed layer depth. Anticyclones deepen the mixed layer depth, whereas cyclones thin it, with the magnitude of these eddy‐induced mixed layer depth anomalies being largest in winter. Eddy‐centric composite averages reveal that the largest anomalies occur at the eddy center and decrease with distance from the center. Furthermore, the extent to which eddies modulate mixed layer depth is linearly related to the sea surface height amplitude of the eddies. Finally, large eddy‐mediated mixed layer depth anomalies are more common in anticyclones when compared to cyclones. We present candidate mechanisms for this observed asymmetry.
Residual Strain Mechanism of Aftershocks and Exponents of the Modified Omori's Law
Authors: Dyskin A. V. , Pasternak E.
Published: December 2018

The rate of aftershocks caused by residual stresses left after a major seismic event or material failure is considered. It is assumed that the local (or “micro” with respect to the scale of the major event) failures registered as aftershocks are produced by static fatigue (delayed fracture). The key point is that the post failure unloading leaves residual strain; the latter induces stresses proportional to the effective (average) moduli. The moduli decay with accumulated microfailures (microcracks or defects or sliding zones), which explains the aftershock rate decay observed by the (modified) Omori's law. It is found that the value of Omori's exponent, p, reveals one of three types of effective moduli decay with the number of aftershocks: p = 1 (the original Omori's law) corresponds to the exponential reduction of the effective moduli, typical for isotropic distribution of accumulated microcracks or sliding zones; p < 1 (the modified Omori's law) corresponds to the power law reduction of the effective moduli, typical for parallel sliding zones; p > 1 (the modified Omori's law) corresponds to the emergence of critical number of defects. This can be indicative of approaching critical event, that is, major seismic event or failure.
How Many Hydrated NEOs Are There?
Authors: Rivkin Andrew S. , DeMeo Francesca E.
Published: December 2018

Hydrated minerals are tracers of early solar system history and have been proposed as a possible focus for economic activity in space. Near‐Earth objects (NEOs) are important to both of these, especially the most accessible members of that community. Because there are very few identified hydrated NEOs, we use the Ch spectral class of asteroids as a proxy for hydrated asteroids and use published work about NEO delivery, main‐belt taxonomic distributions, NEO taxonomic distributions, and observed orbital distributions to estimate the number of hydrated asteroids with different threshold sizes and at different levels of accessibility. We expect 53 ± 27 Ch asteroids to be present in the known population of NEOs >1‐km diameter, and using two different approaches to estimate accessibility we expect 17 ± 9 of them to be more accessible on a round trip than the surface of the Moon. If there is no need to define a minimum size, we expect 700 ± 350 hydrated objects that meet that accessibility criterion. While there are few unknown NEOs larger than 1 km, the population of smaller NEOs yet to be discovered could also be expected to contain proportionally many hydrated objects. Finally, we estimate that hydrated NEOs are unlikely to bring enough water to account for the ice found at the lunar poles, though it is possible that asteroid‐delivered hydrated minerals could be found near their impact sites across the lunar surface.
Linking Marine Plankton Ecosystems and Climate: A New Modeling Approach to the Warm Early Eocene Climate
Authors: Wilson J. D. , Monteiro F. M. , Schmidt D. N. , Ward B. A. , Ridgwell A.
Published: December 2018

The fossil record reveals large changes in marine plankton ecosystems linked with both environmental and ecological change across the Cenozoic. An understanding of the drivers of these changes is key to understanding the marine carbon cycle. The response of plankton ecosystems in past warm climates also provides a key analogue for current climate change. While models are employed to quantify interactions between the environment and the biota, current Earth system models strongly encode our understanding of modern marine ecosystems. By contrast, trait‐based models aim to describe the marine plankton ecosystem in terms of fundamental ecological and physiological rules that are less likely to change through time. This provides a unique opportunity to assess the interactions between marine ecosystem and paleoclimate. For the first time, we apply a size‐structured trait‐based plankton ecosystem model embedded in the Earth system model of intermediate complexity, cGENIE, to model plankton communities for the warm climate of the early Eocene. Compared to modern, we find the warm climate is associated with an increase in the mean cell size of plankton communities and export production, particularly in the southern high latitudes, along with lower total phytoplankton biomass. Paleogeography has an important role in regulating the effect of ecosystem structure via changes in ocean circulation and nutrient cycling. Warmer temperatures also drive changes due to enhanced zooplankton grazing. An integration of the fossil record with plankton ecosystem models will provide a powerful tool to assess the impacts of warm climates on marine systems.
HCRP-1 regulates EGFR–AKT–BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer
Authors: Chen Feifei , Zhang Lei , Wu Jianqiang , Huo Fuchun , Ren Xin , Zheng Junnian , Pei Dongsheng
Published: December 2018

Hepatocellular carcinoma-related protein-1 (HCRP-1), a subunit of mammalian endosomal sorting complex required for transport-I (ESCRT-I), is frequently downregulated in various kinds of malignant tumors. The role of HCRP-1 in colorectal cancer (CRC) remains unknown. We investigate the clinical value of HCRP-1 and its impact on anoikis in CRC. The negative expression of HCRP-1 was significantly correlated with tumor size (P = 0.033), PT status (P = 0.001), TNM stage (P = 0.039), and histological grade (P = 0.01). Univariate and multivariate analyses revealed that HCRP-1 was an independent prognostic factor for CRC (hazard ratio (HR) = 0.237, P < 0.001 for 5-year overall survival). In the in vitro assay, we found that HCRP-1 depletion resulted in cell anoikis resistance. Knockdown of HCRP-1 suppressed Bcl-2 interacting mediator of cell death (BIM) expression, with phosphorylation of AKT and p-FoxO3a, which was reversed by AKT siRNA or AKT inhibitor. Further analysis showed that loss of HCRP-1 obviously increased the activation of EGFR. Inhibition of EGFR blocked si-HCRP1-mediated phosphorylation of EGFR, AKT, FoxO3a, and BIM expression. Moreover, the in vivo results revealed that loss of HCRP-1 promoted cancer metastasis. Our findings implied that reduced HCRP-1 expression in CRC resulted in anoikis resistance and contributed to CRC metastasis and poor prognosis. These data may help design effective therapy targeting HCRP-1 pathway to control colon cancer growth and metastasis.
Reduced workforce participation 5 years prior to first Parkinson’s disease sick-leave
Authors: Timpka Jonathan , Dahlström Örjan , Spreco Armin , Nilsson Maria H. , Iwarsson Susanne , Timpka Toomas , Odin Per
Published: December 2018

The importance of understanding the prodromal phase of Parkinson’s disease (PD) by systematic recording of prediagnostic symptoms and reductions in body functions has been highlighted. The aim of this study was to investigate whether persons later diagnosed with PD exhibit increased physician-certified sickness absence 1, 2, and 5 years prior to a first sick-leave episode attributed to PD. A case-control study was performed to analyze data from all nontrivial (exceeding 14 days) sick-leave episodes in Sweden between 2008 and 2014. The 537 incident PD sick-leave episodes were identified as PD sick-leave cases and compared to 537 sick-leave controls identified by matching age, sex, and date of the first day of the sick-leave episode. The total sickness absence and sickness absence due to musculoskeletal diagnoses were found to be increased among the PD sick-leave cases from 5 years prior to the first sick-leave episode ascribed to PD when compared to the controls. No differences between PD sick-leave cases and sick-leave controls were found with regard to mental and behavioral diagnoses. We conclude that the capacity to participate in working life is reduced already at the early prediagnostic stages of PD. This finding can be used as a basis for further research into the process of identifying individuals at risk for developing PD, particularly in combination with further investigation into biochemical, genetic, and imaging biomarkers.
Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli
Authors: Zhang Zhen , Aung Kyaw Min , Uhlin Bernt Eric , Wai Sun Nyunt
Published: December 2018

Cytotoxic necrotizing factor 1 (CNF1), a protein toxin produced by extraintestinal pathogenic Escherichia coli, activates the Rho-family small GTPases in eukaryotic cell, thereby perturbing multiple cellular functions. Increasing epidemiological evidence suggests a link between CNF1 and human inflammatory bowel disease and colorectal cancer. At the cellular level, CNF1 has been hypothesized to reprogram cell fate towards survival due to the role in perturbing cell cycle and apoptosis. However, it remains undetermined how cells survive from CNF1 intoxication. In this work, we show that CNF1 treatment blocks mitosis/cytokinesis, elicits endoreplication and polyploidisation in cultured human colon cancer cells, and drives them into reversible senescence, which provides a survival route for cells via depolyploidisation. Senescence in CNF1-treated cells is demonstrated with upregulation of several senescence markers including senescence-associated β-galactosidase activity, p53, p21 and p16, and concomitant inhibition of the retinoblastoma protein phosphorylation. Importantly, progeny derived from CNF1 treatment exhibit genomic instability exemplified by increased aneuploidy and become more resistant to CNF1, but not to 5-fluorouracil and oxaliplatin, the two agents commonly used in chemotherapeutic treatment for colorectal cancer. These observations display survival features of the cell after CNF1 treatment that may have implications for the potential role of CNF1 in carcinogenesis.
Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe
Authors: Kubo Hidemasa , Hanaoka Kenjiro , Kuriki Yugo , Komatsu Toru , Ueno Tasuku , Kojima Ryosuke , Kamiya Mako , Murayama Yasutoshi , Otsuji Eigo , Urano Yasuteru
Published: December 2018

Rapid diagnosis of metastatic lymph nodes (mLNs) of colorectal cancer (CRC) is desirable either intraoperatively or in resected fresh specimens. We have developed a series of activatable fluorescence probes for peptidase activities that are specifically upregulated in various tumors. We aimed to discover a target enzyme for detecting mLNs of CRC. Among our probes, we found that gGlu-HMRG, a gamma-glutamyl transpeptidase (GGT)-activatable fluorescence probe, could detect mLNs. This was unexpected, because we have previously reported that gGlu-HMRG could not detect primary CRC. We confirmed that the GGT activity of mLNs was high, whereas that of non-metastatic lymph nodes and CRC cell lines was low. We investigated the reason why GGT activity was upregulated in mLNs, and found that GGT was induced under conditions of hypoxia or low nutritional status. We utilized this feature to achieve rapid detection of mLNs with gGlu-HMRG. GGT appears to be a promising candidate enzyme for fluorescence imaging of mLNs.
Figure-ground perception in the awake mouse and neuronal activity elicited by figure-ground stimuli in primary visual cortex
Authors: Schnabel Ulf H. , Bossens Christophe , Lorteije Jeannette A. M. , Self Matthew W. , Op de Beeck Hans , Roelfsema Pieter R.
Published: December 2018

Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in anesthetized mice that neurons in the primary visual cortex (V1) of mice are sensitive to orientation contrast, but it is unknown whether mice can perceptually segregate figures from a background. Here, we examined figure-ground perception of mice and found that mice can detect figures defined by an orientation that differs from the background while the figure size, position or phase varied. Electrophysiological recordings in V1 of awake mice revealed that the responses elicited by figures were stronger than those elicited by the background and even stronger at the edge between figure and background. A figural response could even be evoked in the absence of a stimulus in the V1 receptive field. Current-source-density analysis suggested that the extra activity was caused by synaptic inputs into layer 2/3. We conclude that the neuronal mechanisms of figure-ground segregation in mice are similar to those in primates, enabling investigation with the powerful techniques for circuit analysis now available in mice.