bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of a comparative valuation of the efficiency of using the plasmid construct pBud-VEGF165-FGF2 in models of autograft of the sciatic nerve defect and tubulation with the NeuraGen® collagen tube
Authors: Masgutov R. F , Masgutova G. A , Mukhametova L. R , Idrisova K. F , Mullakhmetova A. F , Syromiatnikova V. Y , Bogov A. A , Salafutdinov I. I , Arkhipova S. S , Salikhov R. Z , Rizvanov A. A
Published: February 2023

Traumatic injuries of peripheral nerves lead to profound disability in patients with partial or total loss of limb function. There remains the question about the use of technologies for detecting defects of the peripheral nerve with concurrent of its regeneration. In the study it has been investigated the effect of the gene-therapeutic plasmid construct pBud-VEGF165-FGF2 with various methods of overcoming 5 mm diastasis of the sciatic nerve: nerve autograft and tubulation with the NeuraGen® tube. In the study groups, assessment of sciatic nerve regeneration was based on functional and morphometric parameters. Direct injection of plasmid pBud-VEGF165-FGF2 stimulates regeneration and restoration of motor function in both groups, but with different efficacy. Comparative analysis of nerve defect replacement in combination with direct gene therapy showed the most effective approach with autologous insertion replacement by comparison to the NeuraGen. Thus, on the basis of the obtained data, we can assert that nerve autograft of the peripheral nerve remains the "gold standard” and provides the best hope of research in combination with the use of various regeneration stimulants.
EVALUATION OF THE SPREAD OF RADICALISM, EXTREMISM, AND TERRORISM IN INDONESIA'S DEFENSE USING AGENT-BASED SIMULATIONS
Authors: Nurdiansyah Hendra , Almubaroq Hikmat Zakky , Risdhianto Agung , Mualim Much
Published: February 2023

The issue of national disintegration is one of the most crucial in the defense of Indonesia. One of the causes of national disintegration is the existence of Radicalism, Extremism, and Terrorism (RET). Radical entities can change using extreme means including violence through acts of terror in achieving their goals. Efforts continue to be made by the Government in anticipating the spread of this RET. Using agent-based simulation modeling techniques, some characteristics in the RET such as numbers are affected, driving factors, the number of agents in a region, and effective strategies. Therefore, this study is aimed at evaluating the spread of RET in Indonesia using agent-based simulations. This research is qualitative descriptive by trying to collect qualitative data as an initial input for the creation of flowchart designs and agent-based simulation models that will eventually be verified and validated. The results of this study illustrate the agent-based simulation in the spread of RET using Netlogo software by paying attention to several parameters such as incubation period, possible exposure to radicalism, extremist severity, availability of rehabilitation centers, and the rate of terrorism infection. From the results of the simulation, it can be said that the parameter greatly affects the percentage of radical agents, agents who are extremists until they become terrorists. This factor can be evidence for policymakers to reduce the spread of RET effectively by increasing religious understanding, strengthening the sense of nationalism and defending the country, and implementing community empowerment strategies. The evaluation of the spread of this RET can eventually strengthen Indonesia's non-military defense. Thus, good defense will have implications for the continuous development and achievement of Indonesia's goals.
Kualitas Hidup Orang Tua dengan Anak DIisabilitas
Authors: Nurhidayah Ikeu , Imtihana Tia , Adistie Fanny
Published: February 2023

Saat ini diperkirakan 9,9 juta anak Indonesia hidup menyandang disabilitas. Orang tua sebagai caregiver utama rentan mengalami penurunan kualitas hidup akibat kesulitan merawat anak dengan disabilitas. Penelitian ini bertujuan untuk mengetahui kualitas hidup orang tua dengan anak disabilitas. Penelitian menggunakan rancangan deskriptif kuantitatif dengan pendekatan cross sectional menggunakan teknik accidental sampling didapatkan 65 sampel yang terdiri dari orang tua dengan anak disabilitas di SLB Negeri Cileunyi. World Health Organization Quality Of Life-BREF (WHOQOL-BREF) adalah instrumen untuk mengukur kualitas hidup, terdiri dari 26 butir pertanyaan, dianalisis menggunakan nilai distribusi frekuensi. Hasil penelitian menunjukkan orang tua rata-rata memiliki kualitas hidup baik pada domain fisik dan psikologis serta sedang pada domain sosial dan lingkungan. Berdasarkan jenis disabilitas, orang tua dengan anak tunadaksa mayoritas memiliki kualitas hidup kategori baik. Berdasarkan faktor yang berkontribusi terhadap kualitas hidup, rata-rata memiliki kategori kualitas hidup sedang hingga baik pada setiap faktor. Kesimpulan dari penelitian ini adalah orang tua dengan anak disabilitas rata-rata memiliki kualitas hidup sedang hingga baik. Upaya mempertahankan dan meningkatkan kualitas hidup orang tua ke arah yang lebih baik mungkin diperlukan terutama pada domain hubungan sosial dan lingkungan dengan merancang program yang mampu meningkatkan kepuasan orang tua terhadap hubungan sosial dan lingkungan tempat mereka tinggal.
Analisis Faktor Resiko Tingkat Berat Bayi Lahir Rendah
Authors: Perwiraningtyas Pertiwi , Ariani Nia Lukita , Anggraini Christine Yunike
Published: February 2023

Prevalensi berat bayi lahir rendah di Indonesia masih cukup tinggi. Hal tersebut dipengaruhi oleh beberapa faktor, diantaranya usia ibu saat hamil, jumlah paritas dan ante natal care. Tujuan dari penelitian ini adalah untuk menganalisis faktor resiko tingkat berat bayi lahir rendah di RS Harapan Insan Sendawar Kabupaten Kutai Barat. Desain penelitian menggunakan cross sectional. Sebanyak 125 responden yang telah dipilih dari populasi ibu hamil dengan usia 15- 40 tahun yang melahirkan bayi dengan berat <2500 gram di RS Harapan Insan Sendawar selama bulan Januari-Desember 2018 menggunakan simple random sampling melalui kertas undian. Data berupa usia ibu saat hamil, frekuensi ante natal care, jumlah paritas, dan berat badan bayi saat lahir diperoleh dari catatan rekam medis RS Harapan Insan Sendawar. Analisis data menggunakan uji Chi Square, hasil uji analisis didapatkan nilai signifikansi masing-masing sebesar 0.712; 1,000 dan 1,000 yaitu >α(0.05). Tidak ada hubungan usia ibu saat hamil, frekuensi ante natal care dan jumlah paritas dengan kelahiran BBLR. Untuk penelitian selanjutnya diharapkan menganalisis faktor lainnya yang menyebabkan terjadinya berat bayi lahir rendah. Sebagai perawat maternitas, dengan mengetahui faktor determinan terjadinya berat bayi lahir rendah, dapat menentukan intervensi apa yang tepat untuk menekan prevalensi berat bayi lahir rendah di Indonesia.
Pengaruh Rendam Kaki Air Hangat dan Musik Klasik Terhadap Tekanan Darah Ibu Hamil dengan Hipertensi
Authors: Ambarsari Elisabeth Meyta , Ermiati Ermiati , Hidayati Nur Oktavia
Published: February 2023

Angka kematian ibu akibat Hipertensi dalam Kehamilan (HDK) masih tinggi. Hal ini dikarenakan keterlambatan mencari pertolongan setelah gejala klinis berkembang menjadi preeklamsi dan eklamsi, yang merupakan komplikasi pengelolaan HDK yang kurang tepat. Penelitian ini memiliki tujuan untuk melihat pengaruh rendam kaki pada air hangat dan pemutaran musik klasik pada ibu hamil dengan hipertensi terhadap penurunan tekanan darah. Penelitian Quasi Experimental One Group Pre-test Post-test design ini melibatkan 30 ibu hamil dengan hipertensi dengan teknik sampling Purposive Sampling. Berdasarkan analisis data didapatkan menggunakan paired T-test, setelah diberikan kedua terapi, terdapat penurunan tekanan darah sistolik dengan rata-rata 14,43 mmHg dan penurunan tekanan darah diastolik sebesar 10,83 mmHg dengan nilai p value 0,000 < 0,05, yang berarti ada pengaruh terapi kombinasi terhadap penurunan tekanan darah ibu hamil dengan hipertensi. Terapi ini dapat menjadi alternative dan dapat diaplikasikan pada ibu hamil dengan hipertensi dengan mudah dalam menurunkan tekanan darah.
MANAGEMENT OF DISMENORE PAIN WITH EXERCISE STRETCH PAINT
Authors: Nuraeni Neni , Solihatin Yuyun , I Rena , N Haifa , L Marisa , Zakiyyah Zakiyyah
Published: February 2023

Dysmenorhoe is a state of pain in the pelvis and the lower abdomen (suprapubic) that happened before or during menstruation. The symptoms of dysmenorrhoea are unpleasant, individually, and subjectively. It happens to teenagers more frequent, menstrual disturbances disorder often experienced, irregular menstrual among others have less and painful menstruation and have more often and affected to their learning process and absences at school because of the prolonged pain. Cat stretch exercise is one of a non-pharmacology kind. The purpose of the activities is to give training to students in reducing pain in SMUN of Tasikmalaya. Quantitative methods approach used one group pretest-posttest—the samples from 20 students with purposive sampling. Results obtained the average before intervention 2,10 and after 1,70 using the Numeric Rating Scale (NRS). T Independent result p 0,002 means cat stretch exercise can reduce dysmenorrhoea. Recommended for teenage girls to apply to do this exercise when experiencing dysmenorrhea.
EFFECT OF MUROTTAL THERAPY ON BLOOD PRESSURE OF PREGNANT WOMEN WITH HYPERTENSION
Authors: Wahyuni Santi , Badriah Badriah , Cahyati Yanti
Published: February 2023

The high incidence of cases of Hypertension in Pregnancy (HDK) increases the risk of maternal and perinatal complications, even maternal death. Complementary therapy can be done to help control blood pressure (TD), murottal therapy is one of the therapies that is conceptually believed to provide a relaxing effect that can help control TD. Murottal therapy can be done only by listening to the chanting of the verse (version A), only the translation (B), or the verse accompanied by the translation (C). These types of differences are as far as researchers know that no one has done the research. The purpose of this study was to determine the effect of murottal therapy on changes in BP of pregnant women with hypertension. Quasi-experimental research design with a pretest-posttest group approach. Obtained 27 respondents with inclusion criteria namely Muslims, TD ≥ 140/90 mmHg, and willing to be respondents. The analysis showed that there were differences in systolic and diastolic BP in groups 1, 2, and 3 before and after murottal therapy versions A, B, C, and there were no significant differences between systolic and diastolic BP between the three groups. In conclusion, the three types of murottal therapy performed to have the same effect in reducing systolic and diastolic BP. This shows that any type of murottal therapy has a significant impact in reducing blood pressure. Researchers recommend the application of murottal therapy in HDK patients as an alternative effort to reduce BP.
The Effectiveness Biscuits In Increasing Hemoglobin Levels In Pregnant Women
Authors: Nua Emanuela Natalia , Adesta Regina Ona , Conterius Rosania E.B.
Published: February 2023

Anemia of pregnancy is still a significant health problem in Indonesia. Various efforts have been made to overcome this problem. Moringa biscuits (Bikelor) processed from Moringa leaves with high iron content are an alternative to increasing hemoglobin levels in pregnant women with anemia. The purpose of this research is to analyze the effectiveness of giving Bikelor to increase Hb in pregnant women with anemia. This research was approved by the health research ethics committee of the Faculty of Medicine, Nusa Cendana University, Kupang. The study used the One Group Pre Test and Post Test Design, conducted from May to October 2020 in the working area of the Waigete and Beru Public Health Centers in Sikka Regency on 20 pregnant women. The research was conducted through 4 stages, namely the stage of making Bikelor, the location of organoleptic testing (testability) for pregnant women to Bikelor, testing of nutrient content, and intervention. The intervention phase was carried out for 14 days in October 2020. The intervention data were analyzed using paired t-test analysis to see the difference in Hb levels before and after giving Bikelor. The results of the study showed that there was a significant difference in the Hb levels of pregnant women before and after being given Bikelor with a p-value of 0.000 (α<0.05). Changes in Hb levels before and after giving Bikelor were 0.8-1.4gr/dl. It showed that Bikelor was one of the food products that can effectively increase Hb levels in pregnant women with anemia. Consumption of Bikelor can increase the Hb level of pregnant women. Pregnant women were expected to continue to consume the iron tablets given or can replace them by consuming Bikelor as a daily snack as much as 4-5 pieces per day
Descriptive Study of Optimizing Family Health Functions in Preventing COVID 19 Transmission
Authors: Luthfa Iskim , Khasanah Nopi Nur
Published: February 2023

COVID 19 has become a world health problem, and Indonesia has declared an emergency status for an outbreak. To prevent transmission of COVID 19, the government has set three policies that are increasing the availability and reliability of infrastructure, involving the industrial world and social education. However, COVID 19 transmission still occurs. Preparedness for COVID 19 transmission starts with the family as a minor system in the community. The Healthy Indonesian Program with a Family Approach is considered an excellent effort to carry out health functions to prevent COVID 19 transmission. This study aimed to optimize family functions in preventing COVID 19 transmission. This study used a descriptive-analytic design. Two hundred and fifty-eight samples were recruited using a consecutive sampling technique. To measure family function using a questionnaire. Data were analyzed by descriptive statistics (i.e., frequency statistics). The frequency statistics showed that most of the respondents have optimally performed family functions in the health sector. Most of the respondents understand COVID 19 (88,4%), they are capable of making decisions (96,9%), they can care for the family (88,8%), they can modify the environment (75,2%), and they can take advantage of health services (81%). This study only captures the extent to which the family optimally performs health functions; it does not provide any form of intervention. The results of this study prove that the family has an important role to play in breaking the transmission of COVID 19.
Prevention Measures and How to Handle Pre-Eclampsia (Literature Review)
Authors: Cahyanti Mia , Hermayanti Yanti , Maulana Indra
Published: February 2023

Preeclampsia is a danger sign for pregnant women, especially at 20 weeks gestation, marked by increased blood pressure. At this time, preeclampsia is the second largest contributor to deaths globally, with preeclampsia worldwide 10% -15%. In Indonesia, there is an increase of 2% every year, indicating that adequate treatment and prevention efforts are needed. At present, most research on the prevention and management of preeclampsia discusses pharmacological treatment, not discussing nursing interventions. This Literature review aims to find out various prevention efforts for preeclampsia that are developing at this time. The research method is a literature study of research results published in 2010-2019. The strategy used to search literature is to use keywords preeclampsia, prevention, treatment methods, and nursing interventions, using  Google Scholar, PubMed, Pro-Quest, Science Direct database, which reviewed using The Joanna Briggs Institute Critical Appraisal tools. The study results illustrate that there are several ways to reduce blood pressure. From 10 articles found one preventionnamely the article about consuming food and nine treatments, include: hypnotherapy, , foot massage, foot bath with warm water, cupping therapy, SEFT therapy, and murotal hearing. All articles described that intervention could reduce blood pressure, but the articles do not explain the reduction mechanism based on the intervention used. This Literature Study is expected to be information and consideration for health workers, pregnant women, and the community to handle pre-eclampsia mothers, with much interventions can doit to reduce pre-eclampsia.
Description Of Knowledge, Attitude, And Behavior At Risk Of HIV Transmission In "X" SMK Students
Authors: Yani Desy Indra , Agustin Fera Imelia , Ibrahim Kusman
Published: February 2023

HIV is a severe health problem. Pangandaran is a West Java tourist spot with a high risk of HIV transmission among adolescents. Knowledge about HIV, attitudes towards HIV transmission behavior, and HIV risk behaviors are essential for every individual because adolescents are a vulnerable population. This study aims to identify knowledge, attitudes, and risk behaviors for HIV transmission. This descriptive research with the research population is teenagers class XI and XII in SMK "X" Pangandaran, as many as 915 people. Data collection using proportionate stratified random sampling technique with a sample of 278 students online. Data collection was carried out within one month and distributed using Google Form using a modified Knowledge, Attitudes, and Risk Behavior related to HIV (PSP-HIV) questionnaire, which had been tested for validity and reliability. Data were analyzed using univariate in the form of frequency distribution for knowledge and attitudes. Risk behavior is grouped based on the frequency and percentage of respondents' answers to each statement. The results of this study found that (71.6%) of adolescents had less knowledge about HIV. A total of (54.7%) of adolescents have a terrible attitude toward HIV transmission behavior. The three risk behaviors for HIV transmission with the highest scores among students in this study were: 1) using protection or condoms during sexual intercourse as much as 5.4%; 2) having sex with girlfriends as much as 5%; 3) having sex with friends as much as 3.2%Adolescents must be provided with accurate and complete information so that they do not become a vulnerable group to suffer from HIV.
Self-Efficacy and Compliance Fluid Intake Restriction as a Determinant of The Interdialytic Weight Gain (IDWG) Level
Authors: Wayunah Wayunah
Published: February 2023

Higher interdialytic Weight Gain (IDWG) is commonly experienced by patients with chronic kidney disease (CKD). Increased IDWG can cause various complications that result in risk of death. CKD patients who had undergoing hemodialysis in the Public Regional Hospital of Indramayu would have different weight gain, but it is not known what factors affect the increase in IDWG. The purpose of this study was to determine the factors that were significantly related to the IDWG level in CKD patients in the Public Regional Hospital of Indramayu. This research design is descriptive-analytic. The number of samples was 86 respondents who were selected by consecutive sampling technique. Data collection tools are questionnaires and the data analysis technique is the Pearson chi-square test. From the result from 86 respondents, it is known that 44 (51.2%) respondents experienced an increase in IDWG level at the mild category (<4%). It is known that the factor influencing to level of IDWG are self-efficacy (p-value = 0.000; 95% CI) and fluid intake compliance (p-value = 0.042; 95% CI). Meanwhile, age, sex, education level, family support, and duration of hemodialysis are not influencing the IDWG level (p-value > 0,05; 95% CI). Self-efficacy and fluid intake compliance are the most significant factor on the IDWG level in CKD patients who had hemodialization. Patients with high self-efficacy can reduce the IDWG level accompanied by compliance with fluid restriction. Recommendation for hemodialysis nurses needs to increase the patient’s self-efficacy in limiting fluid so that can be controlled at the IDWG level.
The Relationship of Knowledge Level and Attitudes of Prospective Umrah Pilgrims with The Compliance of Meningitis Vaccination
Authors: Rahayuningrum Dwi Christina , Sartiwi Weni , Yuniko Fajrihuda
Published: February 2023

The meningococcus vaccine is a vaccine that must be given to all people traveling to Saudi Arabia. This vaccine was needed in 2006 due to the meningococcus disease outbreak in Saudi Arabia from 1987-2003 and the disease infected pilgrims. Saudi Arabia reported an increase in the incidence of meningitis as many as 225 cases with 56 deaths, and it was reported that the number of Indonesian pilgrims was 14 cases of meningitis, with six died in Saudi Arabia. There are three people suspected of contracting meningitis during the Hajj season 2017 in West Sumatra. The Port Health Office (KKP) reported that out of 1228 total meningitis vaccination visits, 245 people (19.95%) were vaccinated less than 30 days before departure. This study aims to analyze the relationship between the level of knowledge and attitudes of prospective Umrah pilgrims with meningitis vaccination compliance. Quantitative method research with a cross-sectional research design with accidental sampling technique with a sample of 37 people at the Padang Port Health Office (KKP) in August 2019. The research instrument used a questionnaire through interviews and computerized processing techniques. The results showed that 70.3% of the Umrah pilgrims had a low level of knowledge, 54.1% of the pilgrims had negative attitudes, and 56.8% of the congregation respondents did not comply with the meningitis vaccination. It is hoped that the Padang City Port Health Office will increase the provision of information or socialization related to the timeliness of the meningitis vaccination for prospective Umrah pilgrims.
Application of Artificial Intelligence for managing Diabetes Mellitus patients during the Covid-19 pandemic
Authors: Sari Lia , Darmawulan Nurul , Agustina Feni , Nursiswati Nursiswati
Published: February 2023

The Covid-19 quarantine policy and mobility restriction were carried out to break coronavirus transmission. These were implemented for several months to affect the quality of life, especially in patients with diabetes mellitus. To overcome this, technology such as applications with artificial intelligence can be used. This literature aims to identify the use of Artificial Intelligence systems in managing diabetes mellitus during pandemics. This review conducted a narrative review method. Articles were searched using databases, such as PubMed, Science Direct, and EBSCO. The keywords were based on the medical subheading (MeSH) term and combined using a boolean operator. Articles were selected using inclusion criteria, namely the year of publication between 2016-2021, articles in English, full text, and open access. The articles that were duplicated and articles that did not fit the research topic were excluded. We found that six articles met the criteria. These discussed four programs, namely diabetes retinopathy screening, blood glucose monitoring, lifestyle management programs, and insulin therapy guidelines. The four programs can be used in the home care services for diabetes mellitus patients during the Covid-19 pandemic
Preparations methods of tizanidine (API) and related compounds: A review
Authors: Ali Korany A. , Ragab Eman Ali
Published: February 2023

Tizanidine is an imidazoline derivative with the agonistic activity of central alpha 2 receptors at both the spinal and supra-spinal levels. It was prepared for the first time in 1978 and approved for use in 1996. The present review focuses on all methods used for the synthesis of tizanidine, related compounds and intermediates. This review article covers all the methods that have been used in the preparation of tizanidine since its discovery until now. Methods used for the preparation of tizanidine-related compounds are also covered. This review gives those interested in drug synthesis and designs the ability to form a complete picture of the preparation of this drug, as well as providing the opportunity for the synthesis of other drugs developed from this drug to increase activity and/or reduce side effects.
PERAN KINERJA KEUANGAN DAN GOOD CORPORATE GOVERNANCE PADA PENGUNGKAPAN SUSTAINABILITY REPORT
Authors: Sitanggang Daniel Ortega , Paramitadewi SettingsHyasshinta Dyah Sweztika Lukitaning
Published: February 2023

This study aims to analyze financial performance and good corporate governance's role in sustainability reports. The method used in this research is descriptive analysis method and multiple linear analysis, and the data is processed through Statistical Package for the Social Sciences (SPSS) version 23. This study shows that financial performance positively affect sustainability reports. Meanwhile, good corporate governance proxies with committee audit positively influence sustainability reports compared to the independent commissioner.
PENGARUH PROFITABILITAS, LEVERAGE, UKURAN PERUSAHAAN, OPINI AUDIT, DAN PENGHINDARAN PAJAK TERHADAP PENERBITAN LAPORAN AUDIT
Authors: Niocolas Jessica Ovelia , Lukman Lukman
Published: February 2023

The purpose of this study was to investigate the effect of using accounting information on business success. This study also investigates the effect of venture capital on business success. This study uses a survey method conducted by collecting questionnaires for MSME actors in Makassar City. Data analysis in this study using multiple regression method and sample selection using Random Sampling method with a total sample of 94 respondents. The results of this study indicate that the use of accounting information has a significant positive effect on business success. The influence of venture capital also has a positive effect on business success. In short, the use of accounting information and venture capital fully has an influence on business success.
How thermophotovoltaics can help decarbonize the grid
Authors: LaPotin Alina , Henry Asegun
Published: February 2023

Thermophotovoltaics (TPV) are a technology that can turn light into electricity, just like solar panels. However, instead of taking their energy from the sun, TPVs make use of the light emitted by a hot object in close proximity. We demonstrated a new record-breaking efficiency of more than 40% for TPVs, enabling the viability of this technology for ‘thermal battery’ energy storage.
Association of Hs-CRP Levels in Patients with Acute Coronary Syndromes and it’s Correlation with Angiographic Severity of Coronary Artery Stenosis
Authors: Sharma Aditya
Published: February 2023

Objectives:

Significant advances have been made toward the development of biomarkers for prognostication of patients with atherosclerotic cardiovascular disease. One such marker is high-sensitivity C-reactive protein (hsCRP). It is a marker of inflammation mainly used to predict the risk of adverse cardiovascular (CV) events. Recent research also supports its role in atherogenesis. It is involved throughout the process of atheromatous plaque development. However, limited information is available about the relationship between levels of hs-CRP levels in patients presenting with acute coronary syndromes (ACS) and its association with outcomes. We conducted this study to assess the correlation between the levels of hs-CRP and the coronary angiographic findings in patients presenting with ACS and its correlation with outcomes.

Materials and Methods:

we carried an observational prospective study in patients presenting with ACS admitted to cardiology intensive coronary care unit in a tertiary care hospital. Patients underwent invasive coronary angiogram and serum Hs-CRP levels testing apart from other routine investigations. Correlation between severity of coronary stenosis, Hs-CRP levels and left ventricular ejection fraction (LVEF) at discharge was then assessed using statistical analysis.

Results:

Positive correlation was found between Hs-CRP levels and severity of coronary stenosis. Negative correlation was found between Hs-CRP levels and LVEF at discharge.

Conclusion:

We found that hs-CRP levels correlate well with angiographic severity. It was also observed that higher the hs-CRP levels more the number of vessels involved with patients with the left main + triple vessel disease (TVD) and TVD having maximum scores.
Tools for Synthesis Planning, Automation, and Analytical Data Analysis
Authors: Cretu Miruna , Alberts Marvin , Chakraborty Anubhab , Leonov Artem , Thakkar Amol , Laino Teodoro
Published: February 2023

Computer-aided synthesis design, automation, and analytics assisted by machine learning are promising resources in the researcher’s toolkit. Each component may alleviate the chemist from routine tasks, provide valuable insights from data, and enable more informed experimental design. Herein, we highlight selected works in the field and discuss the different approaches and the problems to which they may apply. We emphasize that there are currently few tools with a low barrier of entry for non-experts, which may limit widespread integration into the researcher’s workflow.
Bayesian Optimization for Chemical Reactions
Authors: Guo Jeff , Ranković Bojana , Schwaller Philippe
Published: February 2023

Reaction optimization is challenging and traditionally delegated to domain experts who iteratively propose increasingly optimal experiments. Problematically, the reaction landscape is complex and often requires hundreds of experiments to reach convergence, representing an enormous resource sink. Bayesian optimization (BO) is an optimization algorithm that recommends the next experiment based on previous observations and has recently gained considerable interest in the general chemistry community. The application of BO for chemical reactions has been demonstrated to increase efficiency in optimization campaigns and can recommend favorable reaction conditions amidst many possibilities. Moreover, its ability to jointly optimize desired objectives such as yield and stereoselectivity makes it an attractive alternative or at least complementary to domain expert-guided optimization. With the democratization of BO software, the barrier of entry to applying BO for chemical reactions has drastically lowered. The intersection between the paradigms will see advancements at an ever-rapid pace. In this review, we discuss how chemical reactions can be transformed into machine-readable formats which can be learned by machine learning (ML) models. We present a foundation for BO and how it has already been applied to optimize chemical reaction outcomes. The important message we convey is that realizing the full potential of ML-augmented reaction optimization will require close collaboration between experimentalists and computational scientists.
Latent Pronucleophiles in Lewis Base Catalysis: Enantioselective Allylation of Silylated Stabilized Carbon Nucleophiles with Allylic Fluorides
Authors: Kumar Suresh , Lange Markus , Zi You , Görls Helmar , Vilotijevic Ivan
Published: February 2023

Lewis base catalyzed allylations of C-centered nucleophiles have been largely limited to the niche substrates with acidic C-H substituted with C-F bonds at the stabilized carbanionic carbon. Here we report that the concept of latent pronucleophiles serves to overcome these limitations and allow for a variety of common silylated stabilized C-nucleophiles to undergo enantioselective allylations using allylic fluorides. The reactions of silyl enol ethers afford the allylation products in good yields and with high degree of regio / stereoselectivity as well as diastereoselectivity when cyclic silyl enol ethers are used. Further examples of silylated stabilized carbon nucleophiles that undergo efficient allylation speak in favor of the broad applicability of this concept in the arena of C-centered nucleophiles.
Versatile triphenylphosphine-containing polymeric catalysts and elucidation of structure-function relationships
Authors: Sanders Matthew , Chittari Supraja , Sherman Nicole , Foley Jack , Knight Abigail
Published: February 2023

Synthetic polymers are a modular solution to bridging the two most common classes of catalysts: proteins and small molecules. Polymers offer the synthetic versatility of small molecule catalysts, while simultaneously having the ability to construct microenvironments mimicking those of natural proteins. We synthesized a panel of polymeric catalysts containing a novel triphenylphosphine acrylamide monomer (TPPAm) and investigated how their properties impact the rate of a model Suzuki-Miyaura cross-coupling reaction. Systematic variation of polymer properties, such as molecular weight, functional density, and comonomer identity, led to tunable reaction rates and solvent compatibility, including full conversion in an aqueous medium. Studies with bulky substrates revealed connections between polymer parameters and reaction conditions that were further elucidated with a regression analysis. Some connections were substrate-specific, highlighting the value of the rapidly tunable polymer catalyst. Collectively, these results aid in building structure-function relationships to guide the development of polymer catalysts with tunable substrate and environment compatibility.
The Impact of Artificial Intelligence on Workers’ Skills: Upskilling and Reskilling in Organisations
Authors: Morandini Sofia , Fraboni Federico , De Angelis Marco , Puzzo Gabriele , Giusino Davide , Pietrantoni Luca
Published: February 2023

Aim/Purpose: This paper examines the transformative impact of Artificial Intelligence (AI) on professional skills in organizations and explores strategies to address the resulting challenges.

Background: The rapid integration of AI across various sectors is automating tasks and reducing cognitive workload, leading to increased productivity but also raising concerns about job displacement. Successfully adapting to this transformation requires organizations to implement new working models and develop strategies for upskilling and reskilling their workforce.

Methodology: This review analyzes recent research and practice on AI's impact on human skills in organizations. We identify key trends in how AI is reshaping professional competencies and highlight the crucial role of transversal skills in this evolving landscape. The paper also discusses effective strategies to support organizations and guide workers through upskilling and reskilling processes.

Contribution: The paper contributes to the existing body of knowledge by examining recent trends in AI's impact on professional skills and workplaces. It emphasizes the importance of transversal skills and identifies strategies to support organizations and workers in meeting upskilling and reskilling challenges. Our findings suggest that investing in workforce development is crucial for ensuring that the benefits of AI are equitably distributed among all stakeholders.

Findings: Our findings indicate that organizations must employ a proactive approach to navigate the AI-driven transformation of the workplace. This approach involves mapping the transversal skills needed to address current skill gaps, helping workers identify and develop skills required for effective AI adoption, and implementing processes to support workers through targeted training and development opportunities. These strategies are essential for ensuring that workers' attitudes and mental models towards AI are adaptable and prepared for the changing labor market.

Recommendation for Researchers: We emphasize the need for researchers to adopt a transdisciplinary approach when studying AI's impact on the workplace. Given AI's complexity and its far-reaching implications across various fields including computer science, mathematics, engineering, and behavioral and social sciences, integrating diverse perspectives is crucial for a holistic understanding of AI's applications and consequences.

Future Research: Looking ahead, further research is needed to deepen our understanding of AI's impact on human skills, particularly the role of soft skills in AI adoption within organizations. Future studies should also address the challenges posed by Industry 5.0, which is expected to bring about even more extensive integration of new technologies and automation.
Improving Metacognitive Ability and Learning Outcomes with Problem-Based Revised Bloom's Taxonomy Oriented Learning Activities
Authors: Parwata I Gusti Agung Lanang , Jayanta I Nyoman Laba , Widiana I Wayan
Published: February 2023

This study aims to analyze the impact of Bloom's revised taxonomy-oriented learning activities with problem-based learning models on students' metacognitive skills and learning outcomes. A quasi-experimental design is used as the research method, and the quasi-experimental design is implemented as a pure post-test-control design. All fourth-year students participated in the study, with a total of 132 students participating. The sample was randomly selected and corresponded to 84 students. A 10-question test was used to collect the data. MANOVA with SPSS support was used as the analytical method. The significance of the test results was < 0.00. According to the results, 0.05. This means that learning that uses a combination of problem-based learning models and learning activities aligned with the revised Bloom taxonomy can influence students' metacognitive skills and learning outcomes. Students are at the central of their learning, so they are actively involved in the learning process. This learning activity develops students' metacognitive skills and provides an opportunity to reflect on what they know about themselves and to be honest and confident in their knowledge. Additionally, learning activities are organized by learning objectives to help students improve their learning outcomes. Doi: 10.28991/ESJ-2023-07-02-019 Full Text: PDF
Existence and Uniqueness Solution of Fractional Order Regge Problem
Authors: Hilmi Hozan , Jwamer Karwan H.F
Published: February 2023

In this paper, we look into a group of fractional boundary value problem equations involving fractional derivative fractional orders  and  there are two boundary value criteria in this equation. The existence and uniqueness solutions are obtained using the Banach fixed point theorem (Contraction mapping theorem) and the Schauder fixed point theorem. based on the method of fractional integral and integral operator, our primary findings are illustrated using examples.
Niosomes: A nanocarrier drug delivery system
Authors: Rahiman Mohammed Noor Hazira  , M Sunitha Reddy
Published: February 2023

Novel approaches in the drug delivery system can be used for drug targeting in which the drug gets distributed in the body in such a manner that drug interacts with the target tissue. Niosomes are a type of novel drug delivery system in which the medication is encapsulated in a vesicle. Niosomes are a non-ionic surfactant based multilamellar or unilamellar vesicles in which a fluid arrangement of solute is completely enclosed by a membrane because of the association of surfactant macromolecules as a bilayer. Niosomes release the drug in a controlled manner through its bilayer. Niosomes can be used to carry both the amphiphilic and lipophilic drugs. Niosomes have a great potential in targeted drug delivery of anticancer and anti-infective agents. Niosomes are used to modify the drug release profile, drug absorption, distribution and elimination for the benefit of improving product efficacy and safety and improving patient convenience and compliance. They are very small and microscopic. Although they are structurally similar to liposomes, they offer several advantages over them. Niosomes are stable, less toxic and less expensive than liposomes. This review article represents the structure of Niosomes, its advantages and disadvantages, applications, method of preparation, and characterization techniques of Niosomes.
Exploratory study of income accessories traders in Tana Toraja Indonesia
Authors: Abdullah  , Nasriah Akil  , A.Syahrul M  , Arianto Taliding  , Jusmaniar N  , Rusnaeni  , Asriani  , Misbahuddin  , Andi Dyna Riana
Published: February 2023

Income is the main goal in trading or transacting. Assigning income at other times in the production or service cycle may reflect a better recognition of activities in a period. While specifically the merchant's income is the income received on the number of goods sold multiplied by the price. This study aims to determine the income of accessories traders in Tana Toraja. The data used in this research is primary data using observation data collection techniques, interviews and documentation. The data analysis technique used is discourse analysis to obtain the income dimensions of accessory traders. The results of this study indicate that the income earned by accessories traders in Tana Toraja is based on the level of conditions that can change the people's standard of living. There are various responses and expectations expressed by accessories traders or the public who have different meanings so that conclusions are drawn using the Creswell setting, and the meaning process picks a premise that becomes a hypothesis and arrives at a conclusion. It was concluded that income is a source that is uncertain or not based on the level of conditions that can change the standard of living of the community. And income is an uncertain source and a definite source of consequence continuous activity.
Induction effect combination of Nigella sativa extract and bovine bone graft to the area of woven bone on the preservation socket post-tooth extraction
Authors: Utari Kresnoadi  , Bima Subiakto Rahmani  , Primanda Nur Rahmania  , Rheyna Annisa
Published: February 2023

Background: Tooth extraction is a common dentistry procedure followed by alveolar bone resorption. Trauma that occurs in tooth extraction will induce exaggerating inflammatory process, leads to increased alveolar bone resorption. Bone resorption can be minimized by administering a combination of Nigella sativa extract and bovine bone graft. The combination material is expected to increase the woven bone area formation and speed up the alveolar bone remodeling process. Purpose: To determine the effect of induction of a combination of Nigella sativa extract and bovine bone graft in the formation of the woven bone area on tooth extraction sockets. Methods: The lower left incisor of Cavia cobaya was extracted and the socket was given materials according to their group, namely, control group, bovine bone graft group, Nigella sativa extract group, and a combination of Nigella sativa extract and bovine bone graft group. Cavia cobaya was sacrificed on day 7 and day 14. Histological observation was carried out with hematoxylin-eosin staining. Results: The highest formation of the woven bone area resulted from the group that was treated with a combination of Nigella sativa extract and bovine bone graft, both on day 7 and day 14. Conclusion: The combination of Nigella sativa extract and bovine bone graft is able to increase the formation of woven bone area in the tooth extraction socket.
Acupuncture & electrotherapy: An alternative and complementary treatment method
Authors: Maria I. Dalamagka
Published: February 2023

Acupuncture involves activating specific points on the skin, usually by inserting needles. Acupuncture was based on the principles of traditional Chinese Medicine. Traditional acupuncturists understood health in terms of a vital force or energy called "Qi" that circulates between the organs along channels called meridians. The flow of 'Qi' energy must be of the right strength and quality in each of these meridians and organs so that health is maintained. Acupoints are located along the meridians and can alter the flow of energy and appear to correspond to nerve endings. There is a distinct difference between traditional and Western acupuncture, but the two approaches overlap significantly. In terms of Western theories, acupuncture induces signals in central nerves that modify the transmission through the spinal cord, as well as the perception of pain in the brain. Electrotherapy leads to stimulation of the sensory and motor nerves, and is especially used in the treatment of pain. Different set of parameters may lead to different physiological effects and treatment may be more specific. Electroacupuncture can be performed with or without needles, activating traditional acupuncture points or choosing points that have a neural background, such as trigger points or tender points. The purpose of this study is to verify that acupuncture works as an effective alternative and complementary treatment method. It is a safe, effective and natural approach, which helps to regain and maintain health and mental well-being.
The Effect Using Wordwall Game Applications To Improve Student’s Vocabulary In Chumchon Ban Phanokkhao School
Authors: Az Zahrah Rizka amalia , Anwar Khoirul
Published: February 2023

This study aims to determine the effectiveness of the wordwall application used by students to increase English vocabulary. This type of research uses quantitative methods with research subjects of class VII, VIII and IX involving 30 students. The data collection method was carried out through pre-test, treatment, and post-test. Analysis of the data presented in this study by comparing the values ​​of the pre-test and post-test (paired sample t test). The results of this study are; (1) there is a significant difference means from pretest and posttest for each class VII (pre = 75.00, post = 92,27), VIII (pre = 78,57, post = 92,14), IX (pre = 76,92, post = 90,00); (2) there is a difference in the average pretest and posttest learning outcomes with a sig value of 0.000 is less than 0.05 (0.000 < 0.05). It concludes that the wordwall application is effective in increasing English vocabulary. In addition, wordwall applications can increase mastery of vocabulary because of the simple steps. So, it might enhance enthusiasm in learning English vocabulary.
Influence of the pyrolysis temperature and pressure on the properties of biochar.
Authors: V.V. Koval , I.K. Malik
Published: February 2023

The aim of this work was to compare the yield, approximate composition, structure and surface morphology of biochar obtained from coniferous cones (SCP) at 400–700 ℃ at different pyrolysis pressures in the range of 0.1–2.0 MPa. The main product of pyrolysis, biochar, has a number of advantages, namely, high calorific value, good thermal efficiency, high biodegradability, a large number of surface functional groups, and the possibility of convenient transportation and storage compared to untreated biomass. However, changes in the composition and structure of biochar obtained from lignocellulosic biomass during pyrolysis under different conditions, as well as the relationship between these properties and the content of the three main components, have not been studied in detail yet. In particular, the ash content, high calorific value (Q), content of functional groups and the mechanism of adsorption of the obtained biochar need further study in order to develop the basis for predicting the possibility of various applications of this product produced from different raw materials. In this work, conifer cones were separately pyrolyzed in a fixed bed reactor under various conditions to further study the effect of biomass components and reaction conditions on biochar yield and properties. The combustion behavior and adsorptive capacity of biochar obtained from SHCP made at various temperatures and pressures was also investigated. The results obtained show that increasing the pyrolysis temperature improves the highest calorific value of the biochar, and increasing the pyrolysis pressure improves the yield of the biochar and increases the amount of surface functional groups and combustion characteristics. For experiments to determine the adsorption capacity of biochar, Pb2+ was chosen due to its inability to biodegrade and high toxicity. The kinetic data for Pb2+ adsorption best fit a pseudo second order model indicating a chemisorption-controlled process. The maximum adsorption capacity for Pb2+ is 235.9 mg/g. Keywords: biochar, interaction of components, pyrolysis conditions, combustion, adsorption of heavy metals. Corresponding author Valentin Valerievich Koval, e-mail: kovalen79@gmail.com