bluuebunny/crossref_metadata_2025 huggingface dataset:
Specifics of value attitudes of agents of social changes
Authors: Vorobyova Irina N.
Published: March 2022

The main purpose of the article is to reveal the specifics of the value core of the attitudes which belong to the most active strata of the population. The theoretical and methodological basis of the work is the action activist approach of V. A. Yadov. The main hypothesis of the research is that the most active part of the population is characterized by achievement-oriented motivation in work, a pronounced locus of responsibility, a tendency to solidarity, and the creative essence of an individual. The research method of collecting information consisted of a mass survey of the population of the city of Cherepovets, Vologda Oblast, based on a representative quota sample in accordance with the sex and age structure of the city aged over 18. A total of 600 people were interviewed in March 2020. Scientific novelty lies in the revealing the most active social group of agents of social changes based on the practices of formal and informal social participation, as well as in the identifying the specifics of their attitudes and values. The basis for identifying the value core of the attitudes of the most active part of the population is the studies of such category as “creative class” identified in the works of R. Florida, Yu. G. Volkov, A. Yu. Maslennikov and others, as well as research on the practical measurement of motives and attitudes of civil and social participation, reflected in the works of S. V. Patrushev, V. V. Petukhov, Yu. B. Savelyev. In the second part of the article, the author proves the fact of a low level of the population’s membership in formal organizations, sufficiently developed practices of informal public participation and widely developed practices of informal support. Analysis of the responses to the indicators of identifying value attitudes among groups of the population representing different levels of social activity made it possible to mark out the main core of value orientations of agents of social changes. The author proves that among activists the motives for achievement in work are most clearly identified through the possibility of showing initiative, self-realization, independence, career prospects. Activists are characterized by such features of creativity in their everyday attitudes as the desire to do something new, even if it is associated with risks and difficulties, enjoyment of creative work. An important component of their attitude is a pronounced responsibility for what is happening in their house, surroundings; they prefer to take responsibility and initiative in solving problems. Agents of social changes are characterized by solidarity, a tendency to unite for collective actions to solve common problems.
ZEB1 is Negatively Correlated with E-Cadherin in Prostatic Anomaly Tissue
Authors: Pratiwi Sari Eka , Wahyuningrum Sri Nuryani , Putri Rachmagreta Perdana , Danarto Danarto , Heriyanto Didik Setyo , Arfian Nur , Haryana Sofia Mubarika , Astuti Indwiani
Published: March 2022

Background: Prostatic anomalies are common in tumor or infection condition. The enlargement of prostate gland affects the epithelial cell polarity that involves epithelial-mesenchymal transition (EMT). Transition into mesenchymal is mediated by transcription factor ZEB1 and E-cadherin protein. Upregulation of ZEB1 and loss of E-Cadherin expression were associated to proliferation and metastasis of malignancy cells. This study aims to describe the correlation of ZEB1 and E-cadherin expression in prostatic anomaly.Materials and method: Samples were Formalin Fixed Paraffin Embedded (FFPE) block consist of 8 block Benign Prostatic Hyperplasia (BPH), 6 blocks High Grade Prostatic Intraepithelial Neoplasia (HGPIN) and 6 blocks Prostate Carcinoma (PCA). The blocks then sliced into 5 sections to be prepared for RNA extraction procedures. ZEB1 and E-Cadherin expression was analyzed by semi-quantitative procedures using PCR and electrophoresis. Correlation between ZEB1 and E-Cadherin espression was analyzed using Spearman’s rank correlation.Results: Relative expression of ZEB1 and E-cadherin mRNA in each group of prostatic anomaly were not significantly different (p>0.05). ZEB1 and E-Cadherin mRNA expression showed a significant and moderate level of negative correlation (p<0.05; 0.40 < r < 0.59). Increasing of ZEB1 mRNA expression will be followed by decreasing of E-Cadherin mRNA expression.Conclusion: ZEB1 negatively correlates with E-cadherin due to EMT process in prostatic anomaly. High expression of ZEB1 induced down-regulation of E-cadherin and vise versa. Various studies can be developed, especially the development of targeted therapy against ZEB1 to suppress the EMT process by increasing the expression of E-cadherin.Keywords: epithelial-mesenchymal transition (EMT), ZEB1, E-Cadherin, BPH, HGPIN, PCA
Reversing Agents in the Treatment of Drug-Resistant Malaria
Authors: Rasoanaivo P. , Ratsimamanga-Urverg S. , Frappier F.
Published: March 2022

Chloroquine (CQ) resistance is a serious problem afflicting the populations in the Third World countries where malaria is endemic. Some strategies have been developed to circumvent the increasing spread of CQ resistance and the alarming emergence of multidrug resistance in malaria. Among these, drug combination has received much attention in the past few years. In this approach, the sensitivity of resistant malaria parasites to antima­ larial drugs can be restored by coadministration of one of the drugs collec­tively named reversing agents or chemosensitizers. The present review gives a update of chemically synthetized and naturally occurring reversing agents that have been proved to potentiate in vitro and/or in vivo the effect of the existing antimalarial drugs.
Development of Steroidal and Nonsteroidal Inhibitors of Aromatase for the Treatment of Hormone-Dependent Breast Cancer
Authors: O'Reilly Jill M. , Brueggemeier Robert W.
Published: March 2022

Aromatase (estrogen synthase) is an enzyme complex responsible for the conversion of androgens to estrogens in the final step in steroidogenesis. Estrogens play important roles in both normal physiology and reproduction and in certain estrogen-responsive disease states, such as hormone-dependent breast cancer. Approximately two-thirds of newly diagnosed breast cancer cases are hormone-dependent breast cancer, and estrogens have potent mitogenic effects on this type of breast cancer. Decreasing circulating estrogen levels could result in effective therapy for hormone-dependent breast cancer. Since aromatase is the rate limiting step
for the biosynthesis of estrogens, it is an appropriate target for inhibition. Over the past two decades, both steroidal and nonsteroidal aromatase inhibitors have been developed that are very potent compounds and very selective for aromatase versus other steroidogenic cytochrome P450 enzymes. The steroidal inhibitor 4-hydroxyandrostenedione has demonstrated clinical efficacy in the treatment of hormone-dependent breast cancer in postmenopausal women and is currently available in Europe. Several potent and selective nonsteroidal aromatase inhibitors are now undergoing extensive Phase II and Phase Ill clinical trials and should become available within the next few years for the treatment of breast cancer in postmenopausal women.
Review on Different Vesicular Drug Delivery Systems (VDDSs) and Their
Applications
Authors: Qushawy Mona , Alenzi Asma M. , Albalawi Sana A. , Alghamdi Shatha G. , Albalawi Rawan F. , Albalawi Hadeel S.
Published: March 2022

Background:

Colloidal dispersions, also known as vesicular drug delivery systems
(VDDSs), are highly ordered assemblies composed of one or more concentric bilayers formed by the
self-assembly of amphiphilic building blocks in the presence of water.

Objectives:

VDDSs are important to target the entrapped drugs at specific sites inside the body, control
the drug release, enhance the drug bioavailability, and reduce undesired side effects.

Methods:

There are different types of VDDSs suitable for the entrapment of both hydrophilic and lipophilic
drugs. According to the composition, VDDSs are classified into lipid-based and non-lipid-based
VDDSs.

Results:

There are different types of VDDSs which include liposomes, ethosomes, transferosomes,
ufasomes, colloidosomes, cubosomes, niosomes, bilosomes, aquasomes, etc.

Conclusion:

This review article aims to address the different types of VDDSs, their advantages and
disadvantages, and their therapeutic applications.
EFIKASI FUNGISIDA MAJEMUK (BAHAN AKTIF: BENALAXYL 8% DAN MANCOZEB 65%) TERHADAP PENYAKIT DOWNY MILDEW (Pseudoperonospora cubensis) PADA TANAMAN SEMANGKA SECARA IN VITRO
Authors: Permatasari Intan Sugiarti , Sulistyowati Liliek , Syib’li Muhammad Akhid
Published: March 2022

Penyakit Downy mildew yang disebabkan jamur Pseudoperonospora cubensis, masih menjadi kendala utama produksi semangka di Indonesia. Pengendalian menggunakan fungisida sintetik masih menjadi pilihan utama para petani hingga saat ini. Penelitian ini dilakukan untuk menguji efektivitas fungisida majemuk bahan aktif Mankozeb 65% dan Benalaksil 8% secara in vitro dalam menekan daya hidup jamur P. cubensis pada daun semangka. Penelitian dilaksanakan di Laboratorium Penyakit Tumbuhan, Jurusan Hama dan Penyakit Tumbuhan, Fakultas Pertanian, Universitas Brawijaya. Penelitian menggunakan rancangan acak lengkap (RAL) dengan 5 perlakuan konsentrasi dan 3 fungisida yang berbeda yaitu mankozeb, benalaksil, dan campuran mankozeb+benalaksil dengan ulangan 4 kali. Variabel yang diamati adalah persentase sporangium jamur P. cubensis utuh dan rusak setelah aplikasi, Tingkat Hambatan Relatif (THR), dan sifat aktivitas fungisida majemuk yang ditentukan berdasarkan nilai Nisbah Ko-toksisitas (NK). Hasil pengamatan diketahui bahwa sporangium P. cubensis berbentuk oval dan berwarna abu-abu keunguan. Sporangium nampak menggerombol disekitar jaringan stomata. Pada penelitian ini, semua perlakuan fungisida dapat merusak sporangium P. cubensis. Presentase sporangium utuh paling rendah ditemukan pada perlakuan fungisida majemuk (mankozeb dan benalaksil) dengan dosis 0,6 g/l yaitu sebesar 15,19%. Nilai THR paling tinggi sebesar 58% ditemukan pada aplikasi fungisida majemuk (mankozeb dan benalaksil). Berdasarkan hasil perhitungan nilai NK, diketahui bahwa fungisida majemuk (mankozeb dan benalaksil) mempunyai sifat sinergistik (NK ≥ 1) yang mampu merusak sporangium P. cubensis yang utuh.
Imaging Evaluation of Mesenteric Ischemia: Is There a Golden Period for This Entity?
Authors: Zargar Ishfaq , Robanni Irfan , Shah Omair , Gojwari Tariq , Rasool Riaz , Choh Naseer , Shera Faiz , Wani Munir
Published: March 2022

Background.The study was aimed at assessing the role of ultrasonography and multidetector computed tomography angiography in evaluating patients with suspected mesenteric ischemia, as well as assessing the effect of the time from presentation to management on mortality and morbidity.

Materials and Methods. Patients with clinically suspected mesenteric ischemia underwent Doppler ultrasound and contrast-enhanced computed tomography. On ultrasonography, we assessed any filling defect in the superior mesenteric artery/vein, narrowing or occlusion of the proximal superior mesenteric artery, ascites, bowel wall thickening, and pneumatosis/portal venous gas. Computed tomography angiography was performed looking for any filling defect in the superior mesenteric artery/vein, superior mesenteric artery/vein calibre, bowel wall thickening, calibre and enhancement and pneumatosis/portal vein gas. Most of our patients underwent emergency surgery and the findings correlated with imaging. All the patients were divided into Group A (n=30) and Group B (n=17) based on the time from presentation to management: within 48 hours of presentation and 48 hours after presentation, respectively.

Results. On computed tomography scan, mesenteric vascular involvement was seen in 27 (55%) patients, mesenteric/intestinal twist was observed in 12 (25%) patients, and non-occlusive mesenteric ischemia was found in 6% of patients. The computed tomography findings were found to have a sensitivity of 86%, a specificity of 94% and an accuracy of 90% in cases of mesenteric ischemia. Among 35 patients operated on, those presenting within 48 hours, had a significantly less mortality (63%) in comparison to those presenting after 48 hours (90%).

Conclusions. Clinical, laboratory and ultrasound features are non-specific in diagnosing mesenteric ischemia. Computed tomography angiography is a sine qua non in mesenteric ischemia diagnosis. Patients with venous ischemia respond well to conservative management. Early intervention within the first 48 hours is associated with better prognosis.
Nursing Care Satisfaction among Patients Infected with Covid-19: A Turkish Perspective
Authors: Gündoğdu Handenur , Tanrıkulu Fatma , Erol Funda , Koç Ferhat , Yılmaz Dilek , Dikmen Yurdanur
Published: March 2022

The aim of this study was to determine the satisfaction with nursing care among patients diagnosed with Covid-19 and related factors.
Materials and Methods. The study was conducted between June and July 2020. The population of the study consisted of 102 patients treated in the Covid-19 clinics of the University Teaching and Research Hospital. The data were collected using the Newcastle Satisfaction with Nursing Care Scale with a total of 19 items, and the Patient Description Form designed to record the sociodemographic characteristics and medical histories. The data were evaluated using the program package IBM SPSS 20.0. To test the significance of the difference between two independent groups, the Student’s t-test was used, and the one-way ANOVA was used to test the significance of the difference between more than two groups.
Results. The results showed that most patients were satisfied with nursing care. A higher level of satisfaction was seen in patients treated in the Covid-19 intensive care units, those with chronic conditions, and those who received information about their health state from nurses. Patients’ family type, sharing fears and worries with nurses, getting information from nurses and the quality of nursing care were the variables significantly associated with patient satisfaction with nursing care.
Conclusions. Satisfaction with nursing care among Covid-19 patients was moderate. When nurses use effective communication skills to meet patients’ care needs, provide patients with adequate information, allow them to express their feelings, and keep them safe, this will further enhance patient satisfaction.
Emphysematous Pyelonephritis and Emphysematous Osteomyelitis: A case report
Authors: Sninate Sanae , Oubaddi Tlaite , Allioui Soukaina , Jroundi Leila , Laamrani Fatima Zahrae
Published: March 2022

Background. Emphysematous osteomyelitis and emphysematous pyelonephritis are both rare entities responsible for a high death rate. The first is defined by the presence of intravertebral or intraosseous gas, while the second is infectious damage to the renal parenchyma and perilesional tissues caused by gas-producing microorganisms and is, therefore, characterized by the formation of gas. Imaging plays a crucial role in making a rapid diagnosis and, thus, the initiation of the necessary treatment.

Case Report. A 66-year-old woman with a medical history of type 2 diabetes mellitus and hypertension presented with the altered general condition and flank pain for 5 days, associated with fever and chills. The patient’s vital signs were remarkable with a disturbed biological workup, which led to emergency abdominal and pelvic computed tomography scanning that revealed emphysematous osteomyelitis of the spine and emphysematous pyelonephritis.

Conclusions. The coexistence of emphysematous pyelonephritis and emphysematous osteomyelitis is a rare life-threatening entity, occurring in patients with comorbidities such as diabetes mellitus. Computed tomography is currently the gold standard in making the positive diagnosis, staging, for a quick and better management and, thus, a favorable prognosis.
Metode procjene dentalne dobi kod odraslih osoba
Authors: Huskić Sara , Cuculić Dražen
Published: March 2022

Određivanje dobi predstavlja jedan od glavnih izazova forenzične znanosti. Koristi se za identifikaciju nepoznatih tijela u forenzici i arheologiji, kao i za procjenu dobi u pravnim, legalnim i kriminalističkim slučajevima. Za procjenu se mogu koristiti zubna tkiva zbog izrazite rezistencije svoje anorganske strukture. Kod odraslih je procjena puno zahtjevnija jer se bazira na analizi degenerativnih promjena koje nastaju starenjem i mogu biti vrlo individualne. Postojeće metode procjene dentalne dobi u odraslih osoba dijele se na morfološke, radiološke, biokemijske i molekularne. Učinkovitost metoda pokazala se različitom u različitim etničkim i dobnim skupinama te nije svaka primjenjiva na svakoj skupini zuba. Glavni nedostatak mnogih metoda jesu zahtjevni laboratorijski postupci i dug vremenski period potreban da se metoda izvrši. Pronalaženje univerzalne, jedinstvene metode procjene dobi u odraslih jedan je od glavnih ciljeva forenzičnih stomatologa danas.
Favorable Impact on Postoperative Abdominal Symptoms in Robot-assisted Radical Prostatectomy Using Enhanced Recovery After Surgery Protocol
Authors: HORI TOMOHIRO , MAKINO TOMOYUKI , FUJIMURA RIKUSHI , TAKIMOTO ATSUYA , URATA SATOKO , MIYAGI TOHRU
Published: March 2022

Background/Aim: This study aimed to examine the effectiveness of enhanced recovery after surgery (ERAS) protocols in robot-assisted radical prostatectomy (RARP). Moreover, this study focused on postoperative abdominal symptoms and compared the perioperative parameters between the ERAS and conventional groups in RARP patients. Patients and Methods: A retrospective analysis was performed on 37 consecutive prostate cancer patients who underwent RARP between January 2020 and September 2021. The ERAS and conventional protocols were received by 16 and 20 patients, respectively, excluding one patient with surgical complications. Results: The incidence and cumulative frequency of postoperative abdominal distention were significantly lower in the ERAS group (p=0.041 and p=0.039, respectively). Although not significant, the first flatus and defecation time tended to be shorter in the ERAS group (p=0.115 and p=0.074, respectively). Conclusion: The ERAS protocol contributes to the reduction in postoperative abdominal distension for patients undergoing RARP.
Enabling Eating Detection in a Free-living Environment: Integrative Engineering and Machine Learning Study
Authors: Zhang Bo , Deng Kaiwen , Shen Jie , Cai Lingrui , Ratitch Bohdana , Fu Haoda , Guan Yuanfang
Published: March 2022

Background

Monitoring eating is central to the care of many conditions such as diabetes, eating disorders, heart diseases, and dementia. However, automatic tracking of eating in a free-living environment remains a challenge because of the lack of a mature system and large-scale, reliable training set.

Objective

This study aims to fill in this gap by an integrative engineering and machine learning effort and conducting a large-scale study in terms of monitoring hours on wearable-based eating detection.

Methods

This prospective, longitudinal, passively collected study, covering 3828 hours of records, was made possible by programming a digital system that streams diary, accelerometer, and gyroscope data from Apple Watches to iPhones and then transfers the data to the cloud.

Results

On the basis of this data collection, we developed deep learning models leveraging spatial and time augmentation and inferring eating at an area under the curve (AUC) of 0.825 within 5 minutes in the general population. In addition, the longitudinal follow-up of the study design encouraged us to develop personalized models that detect eating behavior at an AUC of 0.872. When aggregated to individual meals, the AUC is 0.951. We then prospectively collected an independent validation cohort in a different season of the year and validated the robustness of the models (0.941 for meal-level aggregation).

Conclusions

The accuracy of this model and the data streaming platform promises immediate deployment for monitoring eating in applications such as diabetic integrative care.
Heart Rate Measurement Accuracy of Fitbit Charge 4 and Samsung Galaxy Watch Active2: Device Evaluation Study
Authors: Nissen Michael , Slim Syrine , Jäger Katharina , Flaucher Madeleine , Huebner Hanna , Danzberger Nina , Fasching Peter A , Beckmann Matthias W , Gradl Stefan , Eskofier Bjoern M
Published: March 2022

Background

Fitness trackers and smart watches are frequently used to collect data in longitudinal medical studies. They allow continuous recording in real-life settings, potentially revealing previously uncaptured variabilities of biophysiological parameters and diseases. Adequate device accuracy is a prerequisite for meaningful research.

Objective

This study aims to assess the heart rate recording accuracy in two previously unvalidated devices: Fitbit Charge 4 and Samsung Galaxy Watch Active2.

Methods

Participants performed a study protocol comprising 5 resting and sedentary, 2 low-intensity, and 3 high-intensity exercise phases, lasting an average of 19 minutes 27 seconds. Participants wore two wearables simultaneously during all activities: Fitbit Charge 4 and Samsung Galaxy Watch Active2. Reference heart rate data were recorded using a medically certified Holter electrocardiogram. The data of the reference and evaluated devices were synchronized and compared at 1-second intervals. The mean, mean absolute error, mean absolute percentage error, Lin concordance correlation coefficient, Pearson correlation coefficient, and Bland-Altman plots were analyzed.

Results

A total of 23 healthy adults (mean age 24.2, SD 4.6 years) participated in our study. Overall, and across all activities, the Fitbit Charge 4 slightly underestimated the heart rate, whereas the Samsung Galaxy Watch Active2 overestimated it (−1.66 beats per minute [bpm]/3.84 bpm). The Fitbit Charge 4 achieved a lower mean absolute error during resting and sedentary activities (seated rest: 7.8 vs 9.4; typing: 8.1 vs 11.6; laying down [left]: 7.2 vs 9.4; laying down [back]: 6.0 vs 8.6; and walking slowly: 6.8 vs 7.7 bpm), whereas the Samsung Galaxy Watch Active2 performed better during and after low- and high-intensity activities (standing up: 12.3 vs 9.0; walking fast: 6.1 vs 5.8; stairs: 8.8 vs 6.9; squats: 15.7 vs 6.1; resting: 9.6 vs 5.6 bpm).

Conclusions

Device accuracy varied with activity. Overall, both devices achieved a mean absolute percentage error of just <10%. Thus, they were considered to produce valid results based on the limits established by previous work in the field. Neither device reached sufficient accuracy during seated rest or keyboard typing. Thus, both devices may be eligible for use in respective studies; however, researchers should consider their individual study requirements.
Antimicrobial Resistant Bacteria in Health Care Facilities: Exploring Links With Water, Sanitation, and Hygiene in Gaza, Palestine
Authors: Abushomar Reem , Zeitoun Mark , Abu Sittah Ghassan , Abu Fayad Antoine , Abbara Aula , El Achi Nassim , Elmanama Abdelraouf
Published: March 2022

Background

Antimicrobial resistance (AMR) is a growing global phenomenon; however, its link to water, sanitation, and hygiene (WASH) remains underexplored, particularly in health care facilities where humanitarian crises prevail.

Objective

This study aimed to identify AMR bacteria in samples collected from WASH services in 2 hospitals in Gaza and to investigate the presence of AMR genes.

Methods

A hospital-based cross-sectional study to detect and identify antimicrobial resistance bacteria was conducted. Random samples from water, wastewater, soap, and surface swabs (n=345) were collected from Al-Shifa and European Gaza hospitals and screened for the presence of Enterobacteriaceae, Pseudomonas, Enterococcus, and Staphylococcusaureus. Antimicrobial susceptibility, extended spectrum beta-lactamase (ESBL) production, carbapenem resistance, and AMR genes were investigated.

Results

High levels of bacterial contamination were detected in water and surface swab samples with an overall percentage of 34.1%. Moreover, 22% of the identified Enterobacteriaceae was positive for ESBL, and 14% was positive for modified Hodge test. Over 2/3 of isolated Enterobacteriaceae in water and wastewater samples was found to be resistant to amikacin, ceftazidime, ceftriaxone, and imipenem. All Enterobacteriaceae isolates from swab samples were found to be resistant to piperacillin-tazobactam, amikacin, ceftazidime, and ceftriaxone; 13.8% of S. aureus in water samples was methicillin resistant. The prevalence of ESBL genes among Enterobacteriaceae isolates was 25% OXA, 19.4% SHV, 2.8% KPC, 66.7% TEM, 41.7% blaCTXM, and 5.6% blaCTXM-3. For carbapenem-resistant gene (MDM), the prevalence among Enterobacteriaceae was 11.1%, and among Pseudomonas was 12.5%. The antibiotic susceptibility profile was also presented for Pseudomonas, Enterococcus, and S. aureus.

Conclusions

The results underline the level of contamination with AMR bacteria in WASH samples and highlight the need to consider the safety of WASH service at health care facilities as an essential aspect in the fight against the spread of AMR and to interrupt nosocomial transmission.
The Effect of Transcranial Alternating Current Stimulation With Cognitive Training on Executive Brain Function in Individuals With Dementia: Protocol for a Crossover Randomized Controlled Trial
Authors: Jacobson Natasha , Lithgow Brian , Jafari Jozani Mohammad , Moussavi Zahra
Published: March 2022

Background

Although memory and cognitive declines are associated with normal brain aging, they may also be precursors to dementia.

Objective

We aim to offer a novel approach to prevent or slow the progress of neurodegenerative dementia, or plausibly, improve the cognitive functions of individuals with dementia.

Methods

We will recruit and enroll 75 participants (older than 50 years old with either mild cognitive impairment or probable early or moderate dementia) for this double-blind randomized controlled study to estimate the efficacy of active transcranial alternating current stimulation with cognitive treatment (in comparison with sham transcranial alternating current stimulation). This will be a crossover study; a cycle consists of sham or active treatment for a period of 4 weeks (5 days per week, in two 30-minute sessions with a half-hour break in between), and participants are randomized into 2 groups, with stratification by age, sex, and cognitive level (measured with the Montreal Cognitive Assessment). Outcomes will be assessed before and after each treatment cycle. The primary outcomes are changes in Wechsler Memory Scale Older Adult Battery and Alzheimer Disease Assessment Scale scores. Secondary outcomes are changes in performance on tests of frontal lobe functioning (verbal fluency), neuropsychiatric symptoms (Neuropsychiatric Inventory Questionnaire), mood changes (Montgomery-Åsberg Depression Rating Scale), and short-term recall (visual 1-back task). Exploratory outcome measures will also be assessed: static and dynamic vestibular response using electrovestibulography, neuronal changes using functional near-infrared spectroscopy, and change in spatial orientation using virtual reality navigation.

Results

As of February 10, 2022, the study is ongoing: 7 patients have been screened, and all were deemed eligible for and enrolled in the study; 4 participants have completed baseline assessments.

Conclusions

We anticipate that transcranial alternating current stimulation will be a well-tolerated treatment, with no serious side effects and with considerable short- and long-term cognitive improvements.

Trial Registration

Clinicaltrials.gov NCT05203523; https://clinicaltrials.gov/show/NCT05203523

International Registered Report Identifier (IRRID)

DERR1-10.2196/37282
Helping Patients With Chronic Conditions Overcome Challenges of High-Deductible Health Plans: Mixed Methods Study (Preprint)
Authors: Hu Tiffany Yung-Shin , Ali Iman , Heisler Michele , Levy Helen , Fagerlin Angela , Kullgren Jeffrey T
Published: March 2022

BACKGROUND

A growing number of Americans are enrolled in high-deductible health plans (HDHPs). Enrollees in HDHPs, particularly those with chronic conditions, face high out-of-pocket costs and often delay or forgo needed care owing to cost. These challenges could be mitigated by the use of cost-conscious strategies when seeking health care, such as discussing costs with providers, saving for medical expenses, and using web-based tools to compare prices, but few HDHP enrollees engage in such cost-conscious strategies. A novel behavioral intervention could enable HDHP enrollees with chronic conditions to adopt these strategies, but it is unknown which intervention features would be most valued and used by this patient population.

OBJECTIVE

This study aimed to assess preferences among HDHP enrollees with chronic conditions for a novel behavioral intervention that supports the use of cost-conscious strategies when planning for and seeking health care.

METHODS

In an exploratory sequential mixed methods study among HDHP enrollees with chronic conditions, we conducted 20 semistructured telephone interviews and then surveyed 432 participants using a national internet survey panel. Participants were adult HDHP enrollees with diabetes, hypertension, coronary artery disease, chronic obstructive pulmonary disease, or asthma. The interviews and survey assessed participants’ health care experiences when using HDHPs and their preferences for the content, modality, and frequency of use of a novel intervention that would support their use of cost-conscious strategies when seeking health care.

RESULTS

Approximately half (11/20, 55%) of the interview participants reported barriers to using cost-conscious strategies. These included not knowing where to find information and worrying that the use of cost-conscious strategies would be very time consuming. Most (18/20, 90%) interviewees who had discussed costs with providers, saved for medical expenses, or used web-based price comparison tools found these strategies to be helpful for managing their health care costs. Most (17/20, 85%) interviewees expressed interest in an intervention delivered through a website or phone app that would help them compare prices for services at different locations. Survey participants were most interested in learning to compare prices and quality, followed by discussing costs with their providers and putting aside money for care, through a website-based or email-based intervention that they would use a few times a year.

CONCLUSIONS

Regular use of cost-conscious strategies could mitigate financial barriers faced by HDHP enrollees with chronic conditions. Interventions to encourage the use of cost-conscious strategies should be delivered through a web-based modality and focus on helping these patients in navigating their HDHPs to better manage their out-of-pocket spending.
Perbandingan Skoring Kualitas Hidup Pasien Kanker Menggunakan EORTC QLQ-C30 Dengan FACT-G: Telaah Literatur
Authors: Gayatri Dewi , Wardhani Cynthia Tri , Nuraini Tuti
Published: March 2022

Latar Belakang: Kanker merupakan penyakit yang dapat memberikan efek negatif pada fungsi tubuh sehingga memengaruhi kualitas hidup. Pengukuran kualitas hidup dapat menggunakan berbagai instrumen.Tujuan: Menelaah hasil penelitian mengenai perbandingan skoring kualitas hidup pasien kanker dengan menggunakan EORTC QLQ-C30 dan FACT-G.Metode: Literature review dengan PRISMA checklist sebagai protokol. Analisis bias menggunakan Joanna Briggs Institute (JBI) Critical Appraisal. Pencarian artikel dilakukan Mei-Juli 2020, dengan menggunakan database ClinicalKey, EBSCOhost, Google scholar, ProQuest, dan PubMed. Dari 1.194 artikel yang ditemukan, sebanyak 17 artikel sesuai kriteria inklusi.Hasil: Skor kualitas hidup pada instrumen QoL FACT-G lebih tinggi dibandingkan dengan EORTC QLQ-C30. Selain itu, pada dimensi kualitas hidup dan fisik menunjukkan hubungan yang kuat (r= 0,54—0,76), tetapi lemah pada dimensi sosial (r = 0,00—0,130).Kesimpulan: Penelitian ini merekomendasikan FACT-G sebagai instrumen yang mengukur kualitas hidup secara holistik serta berfokus pada psikososial.
CATEGORIZATION OF ṢIFAT MUSYABBAHAH (ATTRIBUTIVE ADJECTIVES OF ARABIC)
Authors: Afrizal Mohamad , Hadi Syamsul , Suhandono Suhandono
Published: March 2022

Ṣifat musyabbahah (SM) merupakan subkelas nomina Bahasa Arab, yang dimunculkan oleh para tata bahasawan klasik Bahasa Arab, yang bentuk dan maknanya tidak teratur. Tulisan ini bertujuan untuk mengkategorikan SM melalui pendekatan kelas kata lintas-bahasa. Data berupa SM bebas konteks dan SM terikat konteks yang diperoleh dari buku-buku tata bahasa Arab, serta korpus dan kamus daring Bahasa Arab. Kemudian, data dianalisis dengan pendekatan kelas kata lintas-bahasa, yaitu integrasi analisis sintaksis, morfologi, dan leksikal. Hasilnya ialah SM dapat dikategorikan ke dalam 6 jenis SM yang meliputi 1) SM dalam arti sempit, 2) SM sebagai bentuk/wazan antara ism fā’il dan ism maf’ūl, 3) SM sebagai inkorporasi nomina absolut, 4) SM sebagai leksikalisasi metaforis, 5) SM sebagai istilah kekerabatan dan kategori sosial, dan 6) ism non-SM.
SUMUR: Sebuah Cerita Dalam Perspektif Aksiologi
Authors: Mukarromah Bakdiyatul , Pandin Moses Glorino Rumambo
Published: March 2022

Buku karya Eka ini mampu mengajak pembaca untuk menyelami cerita dan menebak-nebak alur ceritanya. Latarnya yang merupakan cerita tradisional klasik yang terjadi di masa lampau sangat khas dengan berbagai problematika yang terjadi di Indonesia kala itu, meskipun jenis karyanya sendiri adalah fiksi. Penggambaran yang diberikan juga sangatlah mendetail dan dilengkapi dengan ilustrasi sederhana pada beberapa bagian cerita, sehingga pembaca dapat mengimajinasikan latar cerita dengan cukup baik
Electricity Consumption and Industrial Performance in Nigeria
Authors: Bassey Christian E. , Anagha E. Oduneka, , Ikpe Imoh kingsley
Published: March 2022

Over the years, demand for electricity has continued to grow while supply has consistently declined. The shortages of electricity supply formed the major background for energy crisis in Nigeria. The reason for this is that, all efforts are concentrated at generating electricity from only two major sources, namely: hydropower and gas. Therefore, this study investigated the effects of electricity consumption and its implications on industrial performance in Nigeria. Time series data were used for the study, sourced from the Central Bank of Nigeria Annual Report, Statistical Bulletin, Publications of the International Monetary Fund and the National Bureau of Statistics which spanned from 1981 to 2019. The study employed Fully Modified Ordinary Least Squares Method and Descriptive Statistics to carry out the empirical analysis. The findings revealed that a unit rise in industrial electricity consumption and exchange rate contribute to industrial performance by 9.4% and 44% respectively. This indicator only reflects marginal impact of industrial performance in Nigeria compare to other countries. However, a percentage increase in gross fixed capital formation and gross domestic product reduced industrial performance by 0.018% and 0.020%. Meanwhile, capacity utilization signed positive but not statistically significant. The study concluded that irregular electricity supply has weakened industrial performance in Nigeria despite various energy resources available. Therefore, the study recommended well rounded energy mix option through government policies to complement the existing energy sources available in Nigeria, as well, as other renewable energy resources for industrial sector and domestic use.
Prediction of House Price Using Machine Learning
Authors: Chordia Mr. Piyush , Konde Mr. Pratik , Jadhav Ms. Supriya , Pandhare Hrutik , Pachouly Prof. Shikha
Published: March 2022

Abstract: The trend of the sudden drop or constant rising of housing prices has attracted interest from the researcher as well as many other interested people. There have been various research works that use different methods and techniques to address the question of the changing of house prices. This work considers the issue of changing house price as a classification problem and discuss machine learning techniques to predict whether house prices will rise or fall using available data. This work applies various feature selection techniques such as variance influence factor, Information value, principle component analysis, and data transformation techniques such as outlier and missing value treatment as well as different transformation techniques. The performance of the machine learning techniques is measured by the four parameters of accuracy, precision, specificity, and sensitivity. The work considers two discrete values 0 and 1 as respective classes. If the value of the class is 0 then we consider that the price of the house has decreased and if the value of the class is 1 then we consider that the price of the house has increased.
Optimization of Heat Transfer Rate in Fins by CAE
Authors: Modi Suprit N. , Jaware Prof. R. R.
Published: March 2022

Abstract: Overheating and excessive increase in the temperature of the compressors body causes thermal loading on the compressors surfaces. The life of the compressor mainly depends upon the abrupt change in the thermal stresses and the pressure stress induced in the body. The life of the compressor can be successfully improved and optimized by working on the compressor body. Specifically speaking the compressors fin areas is the heat affected area. Change in small cross section area can significantly change the convective heat transfer. This paper focuses on providing economical methods which are optimized and easily implementable solutions in the existing manufacturing setup. The above techniques are implemented on compressor head body. All possible attempts are made to change the cross section and the shape of the heat transfer areas so that maximized heat transfer reached in the operating process. The implementation of the optimize techniques is carried out by analysing different cross sections such as straight, trapezoidal and parabolic. The scope of revising the strategies ultimately helps to increase productivity, efficiency, pointing to increase the profit. The only aim to propose the solution is to optimize the heat transfer rate by the change in the design Keywords: Heat Transfer, Fins, Compressor, Cross section, efficiency
On entanglement assistance to a noiseless classical channel
Authors: Frenkel Péter E. , Weiner Mihály
Published: March 2022

For a classical channel, neither the Shannon ca-pa-city, nor the sum of conditional probabilities corresponding to the cases of successful transmission can be increased by the use of shared entanglement, or, more generally, a non-signaling resource. Yet, perhaps somewhat counterintuitively, entanglement assistance can help and actually elevate the chances of success even in a one-way communicational task that is to be completed by a single-shot use of a noiseless classical channel.To quantify the help that a non-signaling resource provides to a noiseless classical channel, one might ask how many extra letters should be added to the alphabet of the channel in order to perform equally well without the specified non-signaling resource. As was observed by Cubitt, Leung, Matthews, and Winter, there is no upper bound on the number of extra letters required for substituting the assistance of a general non-signaling resource to a noiseless one-bit classical channel. In contrast, here we prove that if this resource is a bipartite quantum system in a maximally entangled state, then an extra classical bit always suffices as a replacement.
PERCEPTION OF UNDERSTANDING ABILITY OF REDOX CONCEPT ON STUDENT E-LEARNING OUTCOMES
Authors: Suryaningsih Siti , Rahmah Nadiyah Aulia , Aldiansyah Fauzan
Published: March 2022

The application of e-learning greatly impacts the ability to understand concepts and student learning outcomes. The purpose of the study was to determine 1) the prerequisite test of research instruments 2) the perception of the ability to understand redox concepts in e-learning based on indicators of learning stimuli, responses, and evaluations. 3) the relationship of understanding redox concepts to student learning outcomes. The method used is descriptive quantitative, in-class X MIA at MAN Tangerang, 38 students were selected by purposive random sampling. Data collection was carried out through a questionnaire using a Likert scale. The results showed that the prerequisite test was declared valid, reliable, and normally distributed. Student perceptions generally agree based on learning stimulus indicators as much as 71.025%; response 71.075%; evaluation 62.475%. Students give full attention during learning, participate actively during discussions, and understand redox concepts. Understanding redox concepts on student learning outcomes has a significant relationship (strong and positive), seen from the value of sig. (2-tailed) of 0.000 less than 0.05, Pearson correlation of 0.967 greater than 0.329 (significance 5%). The results of this study serve as scientific information on e-learning for chemistry subject teachers in improving the learning process.
THE PROCESS OF CONCEPTUALIZATION IN SOLVING GEOMETRIC-FUNCTION PROBLEMS
Authors: Hutajulu Masta , Perbowo Krisna Satrio , Alghadari Fiki , Minarti Eva Dwi , Hidayat Wahyu
Published: March 2022

Functional analysis has been of interest and the thinking of students should be prepared.  Analyzing the process of conceptualizing geometric function problem solving based on the dimensions of cognitive processes and knowledge was the purpose of this study. The subjects of this study were three students selected purposively from one of the secondary schools in Indonesia. Exploration of these studies with constant comparative techniques. The results of the data analysis show that the cognitive processes that operate and the knowledge applied by students focus on the conceptualization of algebraic representations. Based on the conceptualization process, students' conceptual systems are still fragmented because of the problem of the relationship between the concept and the basis of its relationship. As a result, procedural knowledge is more dominant.
Validación formato para documentar el proceso enfermero en un programa de enfermería
Authors: Morales-Aguilar Rosa del Socorro , Pardo-Vásquez Alba Cecilia , Jinete-Acendra Janeth Cecilia , Barraza-Ospino Damar Paola , Arrieta-Reales Nancy , Pozo-Padilla Carolina
Published: March 2022

Objetivo: diseñar y validar un formato para documentar el proceso enfermero en la enseñanza-aprendizaje de un Programa de Enfermería. Materiales y método: Se realizó un estudio cuali-cuantitativo; la fase cualitativa se ejecutó a través de un grupo focal fundamentada en los referentes teóricos del proceso de enfermería y el lenguaje estandarizado NANDA, NOC & NIC; en la fase cuantitativa se utilizó la metodología DELPHI con validación de panel de expertos de dos etapas, una subjetiva y otra objetiva, se evaluaron suficiencia, relevancia, coherencia y claridad. La tabulación de los resultados de la primera y segunda ronda de expertos, se realizó previamente en una base de datos estructurada en un software de Excel y posteriormente fue realizado el análisis de concordancia procesando la información a través un test pareado. Resultados: Debido a que el p-valor para todos los aspectos de los componentes es menor que 0,05 se puede rechazar la hipótesis nula con un 95,0% de confianza, indicando que hubo una mejora significativa de la ronda 2 con respecto a la ronda 1, revelando una aceptación del formato. Conclusiones: se logró el diseño y validación del formato para documentar el proceso enfermero a partir de la evaluación de los jueces, se obtuvo una versión con resultados positivos en las dos rondas; este se constituirá en una herramienta estandarizada de enseñanza-aprendizaje en la formación académica de los estudiantes.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN OBESITAS SELAMA PANDEMI COVID-19
Authors: Fuadillah Rosada ayu
Published: March 2022

Selama pandemi COVID-19 pembatasan kegiatan berskala besar dapat mempengaruhi pola makan serta aktivitas fisik. Mahasiswa merupakan kelompok golongan yang banyak mengalami stres, hal ini dapat mempengaruhi pola makan mahasiswa. Penurunan aktivitas fisik dan perubahan pola makan yang diakibatkan selama pandemi serta stres dapat menyebabkan kenaikan berat badan dan apabila terjadi dalam jangka waktu panjang dapat menyebabkan obesitas. Jumlah penduduk yang mengalami obesitas di Kota Blitar meningkat dari tahun ke tahun, selain itu didapatkan bahwa terdapat peningkatan konsumsi makanan siap saji dan restoran siap saji di Kota Blitar. Makanan siap saji identik dengan tinggi kalori, tinggi lemak dan rendah serat. Apabila dikonsumsi dalam jangka waktu lama dan tidak diiringi dengan aktivitas fisik dapat menyebabkan obesitas. Tujuan penelitian ini adalah untuk menganalisis faktor-faktor yang dapat mempengaruhi obesitas pada mahasiswa tingkat akhir selama COVID-19. Desain penelitian yang digunakan adalah Case Control. Penelitian dilakukan di Kecamatan Sananwetan dan Kepanjenkidul Kota Blitar. Besar sampel yang digunakan sebanyak 42 orang dengan metode random sampling. Data penelitian dianalisis dengan menggunakan uji chi-square dan odds ratio. Hasil penelitian menunjukkan bahwa terdapat hubungan antara tingkat konsumsi protein (p=0.04 ; OR= 4.5) dan lemak (p = 0.00) dengan obesitas. Sedangkan asupan energi, karbohidrat dan aktivitas fisik tidak menunjukkan hubungan (p>0.05)
Diagnostic Dilemma In Diagnosing Rare Cause Of Protein Losing Enteropathy:Waldmann’s Disease
Authors: Prajapati Sarita , Bohara Sujan , Mainali Gaurab , Karki Samikshya , Thapa Sharan , Aryal Nirjala
Published: March 2022

Waldmann’s disease / Primary intestinal lymphangiectasia, is an unusual
cause of protein losing enteropathy primarily characterized by
lymphopenia, hypoalbuminemia and hypogammaglobulinemia. However,
variable clinical presentation results in diagnostic dilemma and
effective management. We present a toddler diagnosed with Waldmann’s
disease managed with high protein diet and medium chain triglycerides
supplementation.
Metabolic signatures of rhizobacteria-induced plant growth promotion
Authors: Jeon Je-Seung , Rybka Dominika , Carreno-Quintero Natalia , Vos Ric de , Raaijmakers Jos , Etalo Desalegn
Published: March 2022

Various root-colonizing bacterial species can promote plant growth and
trigger systemic resistance against aboveground leaf pathogens and
herbivore insects. To date, the underlying metabolic signatures of these
rhizobacteria-induced plant phenotypes are poorly understood. To
identify core metabolic pathways that are targeted by growth-promoting
rhizobacteria, we used combinations of three plant species and three
rhizobacterial species and interrogated plant shoot chemistry by
untargeted metabolomics. A substantial part (50-64%) of the metabolites
detected in plant shoot tissue was differentially affected by the
rhizobacteria. Among others, the phenylpropanoid pathway was targeted by
the rhizobacteria in each of the three plant species. Differential
regulation of the various branches of the phenylpropanoid pathways
showed an association with either plant growth promotion or growth
reduction. Overall, suppression of flavonoid biosynthesis was associated
with growth promotion, while growth reduction showed elevated levels of
flavonoids. Subsequent assays with twelve Arabidopsis flavonoid
biosynthetic mutants revealed that the proanthocyanidin branch plays an
essential role in rhizobacteria-mediated growth promotion. Our study
also showed that a number of pharmaceutically and nutritionally relevant
metabolites in the plant shoot were significantly increased by
rhizobacterial treatment, providing new avenues to use rhizobacteria to
tilt plant metabolism towards the biosynthesis of valuable natural plant
products.