bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of varietal diversity on the efficiency of protein water extraction from whole flaxseeds
Authors:   Federal Research Center for Bast Fiber Crops, Minevich Irina E. , Goncharova Agata A. ,   Federal Research Center for Bast Fiber Crops, Ushchapovsky Valentin I. ,   Federal Research Center for Bast Fiber Crops
Published: April 2023

Currently, flaxseeds as a source of essential micronutrients and biologically active substances are considered as raw materials for the enrichment of food systems. The high content of protein in flaxseeds (18–25%) is the basis for the development of a variety of protein products. The aim of the work is to study the efficacy of water extraction of flaxseeds of different varieties to create healthy food products. The objects of the study were different varieties of flaxseeds, flaxseed cake, and flaxseeds without mucilage. The removal of mucilage from flaxseeds was carried out by water extraction with distilled water at T 50℃ for 60 minutes. For the extraction, flaxseeds were washed and flaxseed cake was moistened up to a moisture content of 80%. The moistened raw materials were crushed and mixed with an extractant (0.6% NaCl solvent) in a ratio 1:10. The process of water extraction was carried out at T 40℃ for 60 minutes. The determination of the characteristics for the protein extracts isolated from different varieties of flaxseeds and flaxseed cake showed that the highest protein yield was obtained from the varieties of fiber flaxseed: 54–56%. The high protein yield can be explained by the higher protein content in the studied flaxseeds. Lower extraction efficiency from flax oilseed flax (35–44%) may point to the influence of high fat content due to the formation of protein-lipid complexes. The protein yield from flaxseed cake was 26.42%, which is explained by the low content of the water-soluble fraction of proteins in this raw material. The pre-removal of mucilage polysaccharides from flaxseeds is followed by a competitive extraction of water-soluble proteins, which reduced the yield of proteins in the following extraction (15.72 and 20.34%). Therefore, the water extraction of flaxseed raw materials is an economically affordable method for obtaining products containing protein fractions in the native state. The obtained protein extracts are a prospective basis for developing a variety of plant-based drinks with high biological value, plant based dairy products, and dry protein products.
Citizen Engagement in Smart City Planning: The Case of Living Labs in South Korea
Authors: Choo Mijin , Choi Yeon Woo , Yoon Hyewon , Bae Sung Bin , Yoon Dong Keun
Published: April 2023

The smart city is recognized as a new city model for inclusive urban planning. Many local governments are making smart city plans to develop new policies that manage urban issues in South Korea. They identify issues through citizen surveys and decide which issues should be managed with priority. Some governments test developed policies based on citizen engagement. Most local governments use the living labs to encourage citizen engagement in smart city plans since these are public spaces where planners engage citizens to develop innovative and inclusive ideas. This study conducted a content analysis of smart city plans of local government. We analyzed the various approaches to the living lab and examined the stage of the planning process it is utilized in. Additionally, we identified the barrier to the living lab by interviewing people who participated in the smart city plan. According to the analysis, a barrier to citizen engagement exists in smart city plans; most citizen engagement is only used when planners develop ideas for setting visions and goals. It implies that citizen engagement occurs at a limited level in smart city plans and may cause planning to be less inclusive. We suggest that citizen engagement should be considered in the whole planning process to improve the inclusiveness of smart city plans and encourage sustainable citizen engagement.
Fatores demográficos e clínicos associados à sífilis congênita e gestacional
Authors: Luiz Sartoreto Mafra Adriana , Bernardi Cesarino Claudia
Published: April 2023

Introdução: A sífilis congênita e gestacional é uma doença infectocontagiosa sistêmica, de notificação compulsória, com evolução crônica e causada pelo Treponema pallidum. O aumento de casos de sífilis em gestante e congênita ocorreu com a ampliação do teste rápido, redução do uso de preservativos e o desabastecimento de penicilina. Objetivos: Identificar, descrever e avaliar os fatores demográficos, clínicos, laboratoriais e tratamento associados aos casos de sífilis em gestante e congênita no Grupo de Vigilância Sanitária GVS XXX - Jales, localizado no noroeste do estado de São Paulo, Brasil, entre 2013 e 2017. Métodos: Estudo descritivo exploratório realizado nos bancos de dados do Sistema de Informação de Agravos de Notificação e Sistema de Informação sobre Nascidos Vivos em que foram analisadas 153 gestantes com sífilis e 55 casos de sífilis congênita. Resultados: Os casos de sífilis em gestantes ocorreram em mulheres jovens de baixa escolaridade e aumentaram de 13 casos em 2013 para 43 casos ,em 2017. A maioria das gestantes realizou teste treponêmico e não treponêmico. O número de parceiros tratados foi superior ao dos não tratados. A incidência de sífilis em gestante foi de 10,37 casos/mil nascidos vivos e a de sífilis congênita foi de 3,73 casos/mil nascidos vivos. Conclusão: Houve um aumento considerável de casos de sífilis em gestante e congênita no período investigado. Os resultados deste estudo demonstram que ainda há muito que evoluir para o alcance da meta da OMS para a eliminação da sífilis como problema de saúde pública.
Cluster cooperation of rural tourism participants as a mechanism of adaptation to modern challenges (example of western regions of Ukraine)
Authors:   Taras Shevchenko national University of Kyiv, Koroma Nataliia , Tarabarova Inna ,   Taras Shevchenko national University of Kyiv
Published: April 2023

Creation by the state of favourable conditions for the support of small and medium-sized enterprises, as local support, at the territorial level is essential for preserving the integrity of the system in possible opposition to geopolitical and geoeconomic shifts. Such a shift, in particular, is russia’s invasion of the territory of Ukraine. The western regions of Ukraine were the first to face the new challenges and began to adapt, namely the subjects involved in rural tourism actively. Thus, through the analysis of the previous scientific work, the article highlighted the social and economic context of rural areas and overcoming social isolation inherent in the rural environment in general and in the conditions of martial law in particular; and outlined the principles of forming cluster cooperation between relevant subjects as an essential mechanism of their collaboration. As part of the expedition to the western regions of Ukraine, the following were investigated: aspects of the activities of representatives of small and medium-sized enterprises involved in the organization of rural tourism in the territory or are participants in the cluster of rural tourism in conditions of already martial law; conditions for the formation of cluster cooperation between participants, the role of tourism in regional development and the advantages of cluster cooperation for the development of a tourist destination. According to the results of field research in the territory of the western regions, the opinion was confirmed that the cluster approach in the interaction of small and medium-sized business entities involved in a particular direction allows for deepening and improving their work, optimizing production processes, more rationally using the resource potential of the territory, and relatively faster and easier to respond to challenges. Thus, the successful cluster cooperation of subjects involved in the organization of rural tourism, following the example of the western regions of Ukraine, can become an example and an impetus for the implementation of this model of cooperation throughout the country. Cluster participants demonstrated how important it is to mobilize resources, adapt to modern realities, respond to challenges on time, and help their citizens with their work.
Natural factors of formation of recreational potential of Koblivska territorial community (TC)
Authors:   Taras Shevchenko national University of Kyiv, Marymorych Anna , Uliganets Sergiy ,   Taras Shevchenko national University of Kyiv
Published: April 2023

The recreational potential of the territory is the functional basis of recreation and, in a certain sense, its constituent part. That is, recreational potential is a set of natural, cultural-historical and socio-economic prerequisites for the organization of recreational activities in a certain territory. The basis of the assessment of the recreational potential of the territory is the analysis of the role of all recreational resources in the formation of certain branches of recreation, as well as the identification of promising recreational resources, their influence on the creation of new types of recreation, and also shows that its qualitative and quantitative parameters in combination with socio-geographical factors are important objective prerequisites for the development of the recreational complex. This article examines the natural factors that are part of the tourist potential of the Kobleve territorial community. The main attractions, which can be used to identify the most attractive aspects of the studied territory, and which are expedient to use in the development strategy of the area, are highlighted. A comprehensive geographical description of natural objects involved in the tourism sphere within the studied territory was carried out. Brief information about the Kobleve territorial community is provided. This study showed that the available natural resources, characteristic of the territory of the community, are the foundation as a whole for forming the image of the entire region. Also added is a description of natural objects in the adjacent territories, which can potentially be included in tourist routes organized for visitors to the area. The geography of resorts is expanding. The tendency to increase the resorts in the south of Ukraine, the competition among offers on the tourist market requires the latest approaches in the management of tourist activities, both among local self-government bodies and businesses. A satisfied and ecologically educated guest is expected as a result of such interaction. In general, the dynamics of transformations taking place in Ukraine require fundamentally new approaches to planning the development of all branches of the Mykolaiv region, and even more so for those recognized as priority in the region. Tourism is one of the significant industries of the Mykolaiv region.
STRUCTURE OF AGRICULTURAL LANDSCAPES AS THE BASIS OF THE FORMATION OF ZOOCENOSES OF MIDDLE TRANSDNISTER
Authors:   Kamyanets-Podilsky Ivan Ohienko National University, Kamyanets-Podilsky, Ukraine, Prydetkevyc Stanislav , Lisovskyi Andriy ,   Kamyanets-Podilsky Ivan Ohienko National University, Kamyanets-Podilsky, Ukraine, Garbar Vladyslav ,   Kamyanets-Podilsky Ivan Ohienko National University, Kamyanets-Podilsky, Ukraine, Matuz Olga ,   Kamyanets-Podilsky Ivan Ohienko National University, Kamyanets-Podilsky, Ukraine
Published: April 2023

Agricultural landscapes are the most common class of anthropogenic landscapes. In the structure of agricultural landscapes, there are subclasses of field, garden and meadow-pasture landscapes, which collectively make up to 80% of the area of the study area. To establish the influence of agricultural landscapes on the territorial distribution of zoocenoses of terrestrial vertebrates within Middle Transnistria. In the research process, landscape science, ecological and biogeocenotic approaches and principles of complexity and systematicity, natural-anthropogenic coexistence, constructivism, etc. were applied. The study of zoocenoses of anthropogenic landscapes was based on a system of general scientific and specific scientific methods: observation, analysis and synthesis, induction and deduction, comparison and analogy, abstraction and generalization, and the bibliographic method were also used. Records of terrestrial vertebrates, and capture of amphibians, reptiles and small mammals were carried out by faunal methods, taking into account the specifics of individual groups of animals. The share of field landscapes corresponds to an average of 65%, of which the main part is located on watersheds and floodplain terraces. It was found that the zoocenotic composition of field landscapes is relatively impoverished, but the growth of zoodiversity is provided by “migrant animals” and animals that use fields to find food. Garden landscapes of Middle Transnistria occupy up to 5 %. The timeliness of certain groups of terrestrial vertebrates to garden landscapes was studied, a significant part of which belongs to dendrophilous species of birds and mammals. The reduction of anthropogenic load (compared to field landscapes) affected the growth of the species composition of all settled animal species, as well as nesting birds in garden landscapes. It was determined that meadow-pasture landscapes of Middle Transnistria occupy an average of about 9.5 % and are localized, as a rule, on the slopes of river valleys. In separate areas, they enter the plakors and river floodplains. A wider range of terrain types (increasing the number of ecological niches) influenced the growth of the overall species diversity of animals of this subclass of agricultural landscapes. We consider the need for systematic monitoring of zoocenoses in different classes of anthropogenic landscapes to be a generalization of our research. This will make it possible to trace their dynamics and form scientifically based recommendations regarding the protection and rational use of local areas of animal concentration.
PAVLO ZHYTETSKYI: THE HISTORY OF THE UKRAINIAN LANGUAGE IN THE GENERAL SLAVIC CONTEXT
Authors:   Donbas State Pedagogical University, Glushchenko Volodymyr
Published: April 2023

Frontal study of Slavic studies of the 19th century – 30s of XX century testified: the problem of the relationship between vocalism and consonantism in the history of Slavic languages (based on Ukrainian language material) was presented by the Ukrainian linguist Pavlo Zhytetskyi. P. Zhytetskyi put forward a concept within which each considered phonological phenomenon occupies a certain, logically justified place; it is organically included in the general concept, derives from it. According to P. Zhytetskyi, a certain phonological change (the decline of reduced vowels) is the cause of a number of other phonological changes: the decline of reduced vowels as a key process in the «prehistory» and history of the phonological systems of East Slavic languages causes a «chain reaction» in the corresponding vocal and consonant subsystems. P. Zhytetskyi’s thesis that in Slavic languages and their history «poor» vocalism is combined with «rich» consonantism and vice versa, laid the foundations of the historical typology of Slavic languages (on the phonological level) and proved to be very productive in linguistics of the 20th century. It became the basis for the division of Slavic languages into two types – vocalic and consonantal, which were interpreted both in the synchronic and in the diachronic aspect (А. Isachenko, K. Gorshkova, V. Ivanov, V. Kolesov). P. Zhytetskyi reconstructed systems of archetypes and systems of phonetic laws with a similar mechanism (united by a common cause). Thanks to this, the history of the phonetic system of the Ukrainian language in the interpretation of P. Zhytetskyi appears as a chain of causally connected phonetic processes at the level of subsystems (vocalism and consonantism) and signs of sounds (strength and weakness, deafness and sonority, hardness and softness of consonants). This led to the fact that the concept of the connection between vocalism and consonantism in the history of the Ukrainian language by P. Zhytetskyi retained its relevance in comparative-historical and typological linguistics of the 20th century – the beginning of the 21st century.
THE PALEO-BALKAN LANGUAGES IN THE CONTEXT OF GENEALOGICAL CLASSIFICATION: LINGUOHISTORIOGRAPHIC ASPECT
Authors:   Horlivka Institute of Foreign Languages of the Donbas State Pedagogical University, Lykhachova Anzhelika
Published: April 2023

The purpose of the article is to reveal the features of the study of relict Paleo-Balkan languages in their connection with other Indo-European languages in linguistics of the second half of the XIX century – the beginning of the XXI century. It is noted that when identifying a group of Paleo-Balkan languages, a single criterion has not yet been clearly established: both areal and genetic principles are involved. At the same time the material of Paleo-Balkan languages is not fully taken into account in the genealogical classification of Indo-European languages; if Thracian, Phrygian, and Illyrian languages are included in this classification as separate groups, then the place of old Macedonian, “Pelasgian”, and other Paleo-Balkan languages in the classification is not defined. In addition, the traditional genealogical classification does not take into account the special proximity of Paleo-Balkan languages to Armenian, Albanian and Ancient Greek. The discovery and study of Paleo-Balkan languages are briefly described. The connections of Paleo-Balkan languages with Albanian, Armenian, Ancient Greek, Hittite, Luvian, Baltic, Germanic, Slavic and Indo-Iranian languages are revealed. The author of the article focuses on the fact that Paleo-Balkan languages are mainly reconstructed at the phonological, lexical, derivational levels (to a lesser extent – at the morphological and syntactic levels), although due to the limited and uneven corresponding data, such reconstruction is also limited, and in some cases contradictory. From the point of view of Indo-Europeanists, lexical elements of Paleo-Balkan origin are recorded in modern Albanian, Greek, Bulgarian, Romanian and Armenian. The article emphasizes that Paleo-Balcanistics provided significant factual material important for substrate theory and contributed to the development of the linguistic stratigraphy method.
VIDEOGAME DISCOURSE AS A MULTIMODAL ENTITY
Authors:   The state institution “K.D. Ushynsky South Ukrainian National Pedagogical University”, Shalamay Anastasiya
Published: April 2023

This article seeks to review contemporary approaches to researching videogame discourse, such as analyzing it as internet discourse, electronic discourse, or multimodal discourse. It also aims to define “videogame discourse”, distinguish the terms used to describe it in order to avoid terminological confusion (between the terms “videogame discourse”, “computer game discourse”, “internet discourse”, etc.) and to justify the most suitable approach to studying in-game text. The literature overview has shown that the term “videogame discourse” is the most fitting and commonly used out of the abovementioned terms. While videogame discourse is defined as a multilevel entity that encompasses several levels of discourse based on the senders and the receivers of the message (game developers, gamers, game journalists, etc.), this paper focuses primarily on the in-game text programmed by game developers. As video games are multimedia products, analyzing their discourse from a multimodal perspective appears to be the prevailing approach. In addition to the six modes typical of modern video games (i.e., aural, visual, linguistic, gestural, spatial and haptic), the article highlights the procedural mode, which represents creating and conveying meaning through gameplay mechanics. The paper also views videogame discourse as a polygenre, intermedial and transmedial entity, providing both definitions and examples of these terms.
MULTIMODAL COMMUNICATION OF BRITISH MUSEUMS ON FACEBOOK
Authors:   Taras Shevchenko national University of Kyiv, Belova Alla
Published: April 2023

The article is devoted to social media activity of leading British museums, content strategies they implement to share the news and information via multimodal discourse. Museums social media accounts became a significant component of modern online landscape, in particular, during COVID-19 pandemic when millions of people worldwide started looking for some extracurricular recreation, cultural and aesthetic impressions. The pandemic was both, a challenge and an impetus for many museums to increase online presence and intensify their activity on social media. Having faced the closure during the lockdown many museums had to transform their communication on websites and Facebook, Twitter, Instagram to keep in touch with their followers, visitors and members, to inform, educate and entertain the digital audience. Modern technologies helped museums to diversify modes and media, to make social media posts and virtual communication with followers multimodal, to disseminate knowledge in new ways. Leading British museums turned out to be highly innovative and creative and set multimodality. standards in museums communication. Facebook remains the most popular social media platform for museums so the content of Facebook accounts of Madame Tussauds Museum, National Gallery, National Portrait Gallery, Natural History Museum, Victoria and Albert Museum in 2021-2022 was analyzed in terms of multimodality, communication strategies, edutainment, use of elements characteristic of online communication such as hashtags, emoji, conversation style, dialogic principles, user-generated content. Сontent strategies of British museums in Facebook vary depending on their profile. Edutainment, games, puzzles, quizes, light-hearted communication provoke more response, more emotional reaction of followers as well as their engagement into discussions and dialogues, interactive experience.
THE SACRED NUMERICAL CODE IN INTERLINGUAL AND INTERCULTURAL ASPECTS (based on Ukrainian and Chinese numerals)
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Golubovska Iryna
Published: April 2023

This article is devoted to the analysis of Ukrainian and Chinese numerals in their secondary semiotic cultural-symbolic meaning. The impetus for writing this article was the jubilee date – the 95th birthday of the famous Ukrainian linguist – Tetyana Borysivna Lukinova, whose entire life is connected with academic science. It is widely known that her doctoral monograph “Numerals in Slavic Languages” (2000) laid the foundations of Ukrainian comparative-historical Slavic studies in the field of numerals, but little is known in the linguistic world about the author’s contribution into linguistic culturology. The proposed article is an attempt to fill this gap. In its framework, Ukrainian and Chinese numerals are considered in a comparative mode, mainly from 1 to 10, on the ground of the linguoculturogical analysis of Ukrainian numerals, already made by Tetyana Borysivna. The purpose of the article is to clarify the cultural lacunae and discrepancies in the sacred numerical code of two rather distant linguocultures (of course, against the background of their archetypally determined commonalities). The realization of this goal has not only theoretical, but also practical significance: in the modern globalized world, there are still cultural national ethnic differences, which can sometimes become an obstacle to effective international communication. Among other language codes, the numerical one is considered the most important, since ancient times, the number has been considered to have a certain mystical side, which is a carrier of knowledge about the deep essence and nature of things, shut for the human mind. The perspective of this exploration can be, on the one hand, a comparison of the cultural significance of the numerical code from 1 to 10 in Chinese and other Slavic languages (Polish, Czech, Slovenian, etc.), and on the other hand, an expansion of the research material in the numerical sphere.
STYLISTIC MULTIDIMENSION OF THE AUTHOR’S LANGUAGE OF L.-F. СELINE AND V. DOMONTOVYTCH
Authors:   Ivan Franko National University of L’viv, Stetsko Yaryna
Published: April 2023

The first decades of the 20 th century marked the beginning of fundamental changes in artistic expressions and in the very perception and understanding of Ukrainian and French national arts. Limiting ourselves in this article to the analysis of artistic prose speech, and more specifically, the genre of the novel, we see that not only the method and style of presenting the author’s idea, but also the very concept of literary expressiveness underwent revolutionary changes. Figures of both writers, V. Domontovych and L.-F. Celine, cause different attitudes from their fellow citizens. Their actions and views are not always completely understandable and generally known to us today. At the same time, it is impossible not to note the numerous parallel, although often completely different approaches to artistic and literary expression on the part of both writers. The purpose of the article is to identify such parallels and differences in the creative styles of writers. L.-F. Seline’s roman “Voyage au bout de la nuit” and V. Domontovych’s novel “Soilless” are the subject of analysis. In author’s languages, mainly their rhythmic and melodic features are analyzed. The texts are studied by the method of their comparative analysis in view of the national, historical, cultural and biographical and professional features characteristic of both authors. On the basis of the conducted research, we reach conclusions according to which the creative styles of V. Domontovych and L.-F. Celine is likened by the conciseness of the expression; clearly expressed, often syncopated, rhythmic pattern; elements of sound expressive features of artistic expression; the ability to increase and decrease the tempo and increase or decrease the volume; virtuoso manipulation of lexical means of speech. Morphologically, adjectives play a decisive role in describing characters and situations.
Therapeutic angiogenesis as an advanced direction for potentiating the angiogenic effect of coronary artery bypass grafting
Authors: Oleynik B. A. , Plechev V. V. , Starodobov V. I. , Evdakov V. A. , Izhbuldin R. I.
Published: April 2023

Highlights. This review systematizes the results of experimental and clinical studies on the impact of coronary artery bypass grafting on angiogenesis and potential use of pyrimidine derivatives for therapeutic angiogenesis.

Abstract. Coronary artery bypass grafting is the preferred treatment modality for multivessel coronary artery disease. However, the clinical efficacy of the procedure decreases over time due to the progression of atherosclerosis in the bypass grafts and native coronary arteries. In this regard, it is of great scientific and practical interest to disclose the mechanisms affecting the development of the microvasculature during myocardial surgical revascularization, as well as the search for pharmacological substances capable of stimulating the process of angiogenesis during these surgeries to improve short and long-term outcomes. The article presents a review of experimental and clinical studies on the effect of coronary artery bypass surgery on angiogenesis and highlights the place of pyrimidine derivatives in therapeutic angiogenesis in coronary artery disease.
Coronary-coronary bypass grafting in a child with a stab wound of the anterior interventricular artery
Authors: Podkamenny V. A. , Ivanov E. S. , Batekha V. I.
Published: April 2023

Highlights. A successful case of surgical treatment of a child with a stab wound of the heart and damaged anterior interventricular artery is presented.

Abstract. A girl aged 5 years and 9 months was admitted to the hospital in extremely severe condition with multiple stab wounds to the chest and left shoulder and massive bleeding. The child was immediately taken to the operating room due to hemorrhagic shock and injury localized in the anatomical area directly affecting heart function. The wound in the projection of the interventricular sulcus was repaired with one U-shaped suture, hemodynamics was stabilized by inotropic agents. In the postoperative period, heart failure developed due to akinesia of the apical segments, anterior, lateral and anterolateral walls, and reduced ejection fraction. An emergency coronary angiography revealed an occlusion of the anterior interventricular artery (AIV). Emergency repeated surgical intervention was performed. We diagnosed complete intersection of AIV with thrombosis in the proximal and distal segments. Surgical treatment of the coronary stumps enabled satisfactory antegrade and retrograde blood flow. End-to-end coronary-coronary bypass grafting with AIV grafting was performed on the beating heart. The postoperative period was uneventful. Active lifestyle, absence of complaints, and AIV being opaque, including autogenous graft, were reported in the long-term follow up. The presented case proves that effective diagnostic protocol, echocardiography data and appropriate choice of surgical technique led to a positive outcome.
The influence of orthostatic test (or verticalization) on the blood flow through the internal jugular and vertebral veins
Authors: Shumilina M. V. , Kolesnik D. V.
Published: April 2023

Highlights. In the absence of venous pathology during verticalization, there is an increase in venous outflow both through the vertebral veins and through the internal jugular veins. In the absence of venous pathology, the internal jugular veins are the dominant route of venous outflow in clinostasis and orthostasis.

Aim. To study the dynamics of venous outflow along the internal jugular veins (IJV) and vertebral veins (VV) during the transition from horizontal to vertical position.

Methods. The study included 10 healthy women aged 24±2.91 years. Inclusion criteria were as follows: 1) optimal structure of the venous system, in which both of patient`s IJV are approximately symmetrical in cross-sectional area (CSA) and the intensity of the collapse, CSA of IJV exceeds CSA of the common carotid artery by 2–2.5 times, noticeable efficiency of valves during the Valsalva maneuver; 2) venous pressure (VD) in the brachial vein is 18–20 mm Hg. The exclusion criteria were: 1) a history of any disorders of cerebral circulation, symptoms of venous encephalopathy, vertebrobasilar insufficiency, compression of the neurovascular bundle when exiting the chest, arterial hypertension, any cervical spine pathology, hypertrophy and rigidity of the cervical and nodding muscles, 2) arterial pathology of brachiocephalic/intracranial arteries (stenosis, tortuosity, anomalies of the structure), 3) any cardiac pathology, 4) endocrine diseases. The study involved the method of triplex ultrasound with measurements of the cross-sectional areas of IJV, the diameters of VV, time-averaged mean velocity for volumetric blood flow (TAV) in clinostasis and orthostasis. Changes in volumetric venous outflow during verticalization of patients were evaluated as well.

Results. In orthostasis, the mean CSA of IJV decreased from 0.862±0.043 cm2 to 0.19±0.024 cm2 , the mean TAV increased from 6.950±2.373 cm/s to 66,000±6.875 cm/s, the average volumetric blood flow increased from 5.952±2.006 mL/s to 12.425±1.559 mL/s. The mean TAV for VV during verticalization increased from 6,800±2.067 cm/s to 16,000±2.271 cm/s, and the average volumetric blood flow from 0.167±0.051 ml/s to 0.402±0.098 mL/s.

Conclusion. In all cases, the volumetric blood flow along IJV dominated the volumetric blood flow along VV in clinostasis and orthostasis. In the absence of venous pathology, the dominant pathway of venous outflow in clinostasis and orthostasis are IJV.
Systemic Inflammatory Response Syndrome and Serum Procalcitonin in Odontogenic Maxillofacial Infection
Authors: Kabanova Arina A. , Pokhoden'ko-Chudakova Irina O. , Kabanova Svetlana A.
Published: April 2023

INTRODUCTION: The systemic inflammatory response syndrome (SIRS) is a progressive, pathophysiological process which may be caused by a variety of clinical precursor events including local or generalized infection, or non-infective inflammatory process.
АIM: To determine the development of systemic inflammatory response syndrome (SIRS) and serum procalcitonin level in patients with odontogenic infection of the maxillofacial area.
MATERIALS AND METHODS: The prospective observational study evaluated on 158 medical patients from 2015 to 2018 at the Department of maxillofacial surgery, Faculty of Stomatology, Vitebsk state medical University. The patients were divided into 3 groups: 1 group (96 people) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of one space cellular spaces, group 2 (36 patients) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of 24 cellular spaces, group 3 (26 people) had acute purulent odontogenic osteomyelitis of the mandible complicated by Ludwig's angina. Blood tests of all patients were performed. Based on the blood test, breath rate, heart rate and body temperature SIRS was determined.
RESULTS: Acute odontogenic osteomyelitis, complicated by cellulitis, is characterized by the development of SIRS. In case of one cellular space cellulitis SIRS developed in 9.0% of patients, in case of 24 cellular spaces cellulitis in 36.0%, in case of Ludwig's angina in 80.0%. PCT blood level in healthy group was 0.009 (0.0060.018) pg/ml. All patients groups had significantly higher PCT blood level compared with the healthy group: 1 group 0.034 (0.0190.050) pg/ml, U = 23, р = 0.01; 2 group 0.11 (0.060.24) pg/ml, U =12, р = 0.003; 3 group 0.41 (0.301.15) pg/ml, U = 17, р 0.001.
CONCLUSION: Odontogenic maxillofacial infection is accompanied by SIRS. The search for significant diagnostic criteria for the development of life-threatening conditions should continue.
Physiological Peculiarities of Puberty Period of Adolescents Whose Mothers Were Under High Risk of Terroristic Attack
Authors: Temirkhanova Kepiya T. , Deryagina Larisa E. , Pyatibrat Elena D. , Pyatibrat Aleksandr  O.
Published: April 2023

INTRODUCTION: The importance of the study is determined by increasing instability of the society and involvement of civilian population in military conflicts.
AIM: To determine peculiarities of sexual development of adolescents whose mothers experienced life-threatening stress in the period preceding pregnancy.
MATERIALS AND METHODS: To evaluate the evidence of the secondary sexual signs, hormonal status, anthropometric data and immunity parameters, 2,980 medical records and data of preventive examinations of schoolchildren of the Republic of Dagestan were analyzed. The observation group included 1,416 schoolchildren whose mothers experienced a life-threatening mental trauma, and the control group included 1,564 adolescents whose mothers did not face life-threatening situations.
RESULTS: The data of a comparative analysis of the regulation of physiological development of sons of women who suffered a life-threatening mental trauma, show multidirectional changes in the concentration of gonadotropic hormones with higher concentrations of estrogens, low levels of androgens, manifested by retardation of the formation of secondary sexual signs, reduced physical strength and endurance in puberty in comparison with boys of the control group. Daughters of mothers who experienced a life-threatening stress, in contrast to girls of the control group, were characterized in puberty by higher levels of luteinizing, follicle-stimulating hormones, earlier development of mammary glands and growth of pubic hair. At the same time, in transition from the prepubertal to pubertal period, these girls were characterized by earlier reduction of the activity of adrenal cortex in these girls, early menarche in the pubertal period and retardation of stabilization of the menstrual cycle rhythm.
CONCLUSION: The adolescents being the offspring of women, who experienced a psychogenic life-threatening trauma, are characterized by disorders in physiologic maturation: boys by retardation, girls by acceleration and disharmony of the pubertal development.
Suture Failure of Duodenum after Surgery for Complications of Duodenal Ulcer
Authors: Pashkin Korneli P. , Natal’skiy Aleksandr  A. , Motyrova Elena  V. , Lun’kov Il’ya  A. , Matrosov Vyacheslav I. , Mishin Dmitriy  V. , Peskov Oleg  D.
Published: April 2023

INTRODUCTION: The incidence of failure of intestinal sutures in the early postoperative period reaches 26%. The failure of the duodenal sutures leads to formation of high duodenal fistulas, the treatment of which is one of the most complicated surgical tasks. The article describes a clinical case of failure of duodenal suture after surgery for a duodenal ulcer complicated with bleeding. The failure of the duodenal suture could be provoked by hypoproteinemia and anemia, despite the attempts of their compensation. The presented case demonstrates complexity of the clinical course of this pathology and the possibility of successful application of draining surgery with creation of a controllable duodenal fistula, the subsequent healing of which led to recovery of the patient. To create the controllable duodenal fistula, we used a method of external-internal triple drainage of the duodenal zone (retrograde duodenostomy, gastroenteroanastomosis with a short loop, nasogastral probe). At the initial stage, after surgery, the patient received full parenteral feeding, after restoration of the intestinal peristalsis, feeding was continued through a nasointestinal probe. Infusion therapy, transfusion of blood components were conducted, drugs suppressing gastric and pancreatic secretion, were used. On the 35th postoperative day, the discharge through the duodenal fistula and the nasogastral probe significantly decreased, and completely stopped on the 54th day (immediately after X-ray of stomach with barium sulfate as contrast substance). The patient was discharged with improvement for outpatient follow-up at the place of residence on the 60th day after surgery. In the follow-up period no complaints, good appetite, rapid gaining of weight, complete rehabilitation. In one-year follow-up, no long-term complications and consequences for health were observed.
CONCLUSION: A choice of the surgical treatment method of duodenal suture failure remains a subject of discussion. In the presented clinical case, draining surgery with creation of a controllable duodenal fistula proved to be effective. The complete closure of the residual fistula of the duodenum was facilitated by stomach X-ray with use of barium sulfate.
New Pharmacological Approach to Improvement of Quality of Life of Patients after Coronary Artery Bypass Grafting through Stimulation of Neoangiogenesis
Authors: Oleynik Bogdan A. , Evdakov Valer'yan A. , Plechev Vladimir V. , Izhbul'din Ramil' I.
Published: April 2023

INTRODUCTION: Despite the increased volume of rendered high-tech assistance and objective improvement of the condition of the majority of operated patients, the parameters of physical activity and working capacity in this category of patients remain low.
AIM: To study the effect of 5-oxymethyluracil with angiogenic properties on the quality of life of patients in the early and long-term period after coronary artery bypass grafting (CABG).
MATERIALS AND METHODS: The randomized prospective study included two groups of patients: the main group (n = 87) which in the perioperative period of CABG (5 days before and 14 days after surgery), in addition to standard therapy, received the drug 5-oxymethyluracil), and the control group (n = 81) which received standard therapy. The groups were comparable in gender, age, basic clinical and functional characteristics and peculiarities of surgical intervention. The quality of life of patients was determined by the Seattle Angina Questionnaire (SAQ) before CABG surgery (upon admission to the vascular surgery department) and after surgery (after 2 months and 1618 years). There were no statistically significant differences in the preoperative parameters of quality of life in the control and main groups.
RESULTS: In the long-term period of surgical revascularization of the myocardium (1618 years after the operation) the severity of angina according to SAQ was: in the control group 33.30 (20.00-60.00), in the main group 60.00 (33.30-70.00; р = 0.0407). Other scales of SAQ, including physical activity, stability of anginal course, satisfaction with treatment and perception of the disease, did not demonstrate any differences between the studied groups in 2 months or 1618 years after CABG.
CONCLUSION: Perioperative use of 5-oxymethyluracil influenced the improvement of only one parameter of quality of life according to the SAQ questionnaire the severity of angina, with statistically significant differences between the groups in the long-term period of CABG (1618 years after surgery). According to SAQ questionnaire, there was no effect on the remaining parameters of the quality of life with the underlying perioperative use of the studied drug in all follow-up periods.
Prevalence, Predictors and Morphological Patterns of Acanthosis Nigricans Between Obese Non-diabetic Patients on Second Generation Antipsychotics Versus Non-obese Insulin Dependent Diabetes mellitus: A Nested Case-Control Study
Authors: Vidyasagar Pappula , Kamble Ashwini , Khairkar Praveen , Shravya Bogum , Sumera Yasmin , Matety Ashok Rao , Reddy Vishwak , Biswas Rakesh , Ransing Ramdas
Published: April 2023

INTRODUCTION: There is no study in literature for analyzing acanthosis nigricans (AN) in psychotropic induced obesity or hypercholesterolemia.
AIM: To assess the prevalence and explore the predictors and morphological patterns in AN in patients on antipsychotics induced hypercholesterolemia versus those with diabetes mellitus.
MATERIALS AND METHODS: 491 schizophrenia patients on second generation antipsychotics were screened. 26 out of 491 patients have AN and cholesterol 200 mg/dl but non-diabetic. We used MannWhitney U-test, Pearsons 2 test, Fischer Exact and Spearmans correlation coefficient.
RESULTS: In the group of antipsychotics induced hypercholesterolemia having developed AN in 5.29% (26 out of 491) of individuals, we observed significance of Burkes knuckle (p 0.001), knee (p = 0.002), elbow (p = 0.042) compared to patients without hypercholesterolemia. Interestingly Burkes neck severity (p 0.001), neck texture (p = 0.001) and axilla (p = 0.007) index also showed marked differences on MannWhitney U-test and Wilcoxson W-test. On Spearmans correlation coefficient antipsychotics induced hypercholesterolemia was found to affect most positively and significantly as the emergence of AN specifically for neck texture ( = 0.413, p = 0.003) compared to other bodily regions.
CONCLUSION: About 5.29% prevalence of AN in the group having obesity secondary to psychotropic drugs which was significantly less than what even non-obese, insulin dependent diabetic patients who almost had 13.55% prevalence, close to three times. This suggests that diabetes is strongly linked with occurrence of AN lesions and might reflect the continuity in the paradigm of metabolic syndrome as its definitive predictor of severity while obesity is the initiation of phase shift in the process.
Transformation of Risks of Credit Institutions in the Conditions of Digitalization of the Economy
Authors: Филимонова Н.Н. , Слесарева М.Д.
Published: April 2023

Рассмотрены основные тенденции развития деятельности кредитных организаций в условиях цифровой экономики. Проанализировано влияние пандемии на процесс цифровизации финансового рынка. Выделены основные риски, присущие деятельности кредитных организаций в условиях цифровизации экономики, предложены методы их минимизации.

The article discusses the main trends in the development of credit institutions in the digital economy, analyzes the impact of the pandemic on the process of digitalization of the financial market, highlights the main risks inherent in the activities of credit institutions in the conditions of digitalization of the economy and suggests methods of their minimization.
Innovative Method of Rationale for Choice of the Designer Based on the Risk Tolerance Assessment in Architectural and Construction Design
Authors: Асташенко А.Н. , Бычков А.В. , Давыдянц Д.Е. , Зубов А.О. , Зубова Л.В.
Published: April 2023

Представлен метод выбора исполнителя на выполнение архитектурно-строительного проектирования на основе риск-ориентированного подхода с использованием показателей предельной стоимости риска, предельного уровня риска, рискоустойчивости и критериев выбора оптимального решения для минимизации потерь.

The article presents an innovative method of selecting a contractor for architectural and construction design based on a risk-oriented approach using indicators of the marginal cost of risk, the maximum level of risk, risk tolerance and criteria for choosing the optimal solution to minimize losses.
The State and Prospects of Digitalization of Legal Practice
Authors: Дорохов Н.И. , Бирюкова Е.А.
Published: April 2023

Рассматриваются состояние, актуальные проблемы и перспективы развития цифровых технологий в области юридической практики. Анализируется текущее внедрение цифровых сервисов в  судебную практику, уточняются первые шаги к  цифровизации в системе правосудия в России с 2017 года по настоящее время и выявляются некоторые проблемы, связанные с данным процессом. Проанализированы основные объективные причины медленного темпа перехода к тотальной цифровизации системы правосудия в РФ.

The article focuses on the state, current problems, and prospects for the development of digital technologies in the field of legal practice. The current processes related to the introduction of digital services into judicial practice are analyzed, the first steps towards digitalization in the justice system in Russia from 2017 to the present are specified. The authors reveal some problems associated with this process and analyze the main causes for the slow transition to the total digitalization of the justice system in the Russian Federation.
A Case Study on Competency-based Syllabus Design for College Students
Authors:   The Korea Association of Yeolin Education, Cho Jinsuk , Jeon Youngmee
Published: April 2023

This study is a case study on competency-based syllabus design for college students. Based on a literature review, professional advice, analysis of an existing syllabus, and pilot study results, a competency-based syllabus for college students was designed. And students’ satisfaction with this syllabus was analyzed. For this study, 8 professors and 155 students in the pilot study and 264 students completed a survey questionnaire to analyze the students’ satisfaction with the syllabus design. Results indicate the following. First, the competency-based syllabus components were core competency, major competency, subject outline, learning outcomes, classroom operation methods, assessment methods, class rule, weekly lessons plans (learning outcomes, learning content, classroom operation methods, student learning activities-pre class, during class, after class), and learning materials. Second, students showed very positive perceptions of the suitability of syllabus components, especially of the class operation methods and students’ learning activities in weekly lesson plans. Additionally, students' perceptions of the specificity of the syllabus were also favorable. Third, students were satisfied with the final competency-based syllabus for students and anticipated it would be helpful for their learning. Based on the results, this study proposes that the competency-based syllabus design for students should be central to a university’s mission to provide competency-based education. Furthermore, the university should regularly and consistently conduct workshops or training for professors to write syllabuses with more specifics and to use them actively during their classes.