bluuebunny/crossref_metadata_2025 huggingface dataset:
A rare cause of facial nerve palsy in a young infant: Kawasaki disease
Authors: Orgun Ali , Karagöl Cüneyt , Pamuk Utku , Gürsu Hazım Alper , Çetin İlker
Published: March 2019

Kawasaki disease (KD) is a vasculitis in which the most common complication is development of coronary aneurysms. Neurological complications rarely occur in KD patients such as facial nerve palsy (FNP). FNP associated with KD may indicate increased risk of coronary artery aneurysm. Infants with facial nerve paralysis and unexplained-prolonged febrile period should be evaluated with echocardiography. Here in, we present a 4-month-old female with FNP and unexplained fever who was diagnosed KD due to echocardiographic findings.
Percutaneous embolization of congenital portosystemic venous shunt in an infant with respiratory distress
Authors: Alkan Fatoş , Düzgün Fatih , Yüksel Hasan , Tarhan Serdar , Coşkun Şenol
Published: March 2019

A 5-month-old boy with progressive respiratory distress was admitted to our hospital. Physical examination revealed mild tachypnea and retraction. The left main bronchus was found as severely collapsed between the right pulmonary artery and the descending aorta, on the bronchoscopic evaluation. Further evaluation revealed persistent ductus venosus (PDV). As in the fetal period the ductus venosus arises from the posterior aspect of the left portal vein, a PDV is considered another type of intrahepatic portosystemic shunt. Therefore, he was diagnosed with congenital portosystemic venous shunt, leading to persistent respiratory distress. The PDV was closed with Amplatzer vascular plug II, and then he had immediate clinical improvement. Congenital portosystemic venous shunts (CPSS) are rare vascular malformations associated with severe complications. Here we presented a case with progressive respiratory distress as a result of CPSS and rapid improvement after embolization.
SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF CANDESARTAN CILEXETIL WITH IMPROVED BIOAVAILABILITY
Authors: Rao J. Venkateswara , Reddy T. Rama Mohan
Published: March 2019

Candesartan is an angiotensin II receptor blocker with inherent low bioavailability. The present studies entail the optimization and evaluation of self- nanoemulsifying drug delivery system (SNEDDS) of Candesartan in order to enhance its oral bioavailability. For this Capryol 90, Captex 500, Labrasol were used as oil, surfactant and co surfactant respectively. FTIR studies revealed no interaction among the drug and polymers used in the formulation. Based on the physicochemical parameters and in-vitro dissolution studies, F17 prepared with Smix (Surfactant: Co-surfactant) of 3:1 and Oil:Smix of 6:4, was found to be an optimum one. The formulation F17 was found to release 99.12 ± 5.10% drug at the end of one hour and scanning electron microscopic analysis showed nanosized particles. The droplet size of the optimized formulation was found to be 51.7 nm & Z-Average of 59.2 nm. The zeta potential of the optimized formulation (F17) was found to be -15.5 mV. The formulations were also found to be stable over a period of 6 months of testing. From in vivo bioavailability studies Cmax of the SNEDDS 35.2 ± 0.02 ng/ml was significant (p<0.05) as compared to the pure drug suspension formulation 25.1 ± 0.03ng/ml. Tmax of both SNEDDS formulation and pure drug suspension was 1.00 ± 0.03 h and 2.00 ± 0.01 h, respectively. AUC is an important parameter in evaluating bioavailability of drug from dosage form, AUC0-∞ infinity for SNEDDS formulation was higher (160.1±1.04ng. h/ml) than the pure drug suspension formulation 135.3 ± 2.02 ng.h/ml. Statistically, AUC0-t of the SNEDDS formulation was significantly higher (p<0.05) as compared to pure drug suspension formulation. Higher amount of drug concentration in blood indicated better systemic absorption of Candesartan from SNEDDS formulation as compared to the pure drug suspension formulation. The results from this study suggest the requirement for potential use of candesartan as self-nanoemulsifying drug delivery systems.
LIPOSOMAL FORMULATIONS IN CANCER THERAPY: BASIC CONCEPTS TO ADVANCED STRATEGIES
Authors: Jani R. K , Gohil K. M
Published: March 2019

Liposomes, a phospholipid bilayer vesicular system is extensively being used and studied for drug delivery applications in cancer therapy. The reason behind is advantages that liposomes offer such as their biocompatible and non-immunogenic nature, improved bioavailability of anticancer drugs and versatility of efficiently encapsulating both hydrophilic and hydrophobic drugs. Recent advances such as surface functionalization and modifications of liposomes have played very crucial part to overcome limitations associated with conventional liposomal system which eventually has opened up many new and potential ways of cancer therapy. Surface decoration of liposomes with targeting ligand can lead to actively targeted site specific therapy of solid tumor. Recently, a number of liposomal formulations for cancer treatment are already in clinic and many are still under active research. This review discusses about the basics of liposomes such as structural, components, methods of preparation, and mainly focuses on recent advances of liposomal technology which includes various kinds of surface modification of currently used liposomes with efficient passive or active targeted drug delivery along with its mechanism, the advantages and associated drawbacks and their potential applications in treatment of cancer.
PHARMACOKINETIC INTERACTIONS BETWEEN CONCOMITANTLY ADMINISTERED PHENYTOIN WITH RIVAROXABAN
Authors: Reddy Y. Karnakar , Reddy T. Ramamohan
Published: March 2019

In the present investigation it was aimed to evaluate any possible pharmacokinetic interactions between Phenytoin and Rivaroxaban. Study was conducted in Male Wistar rats; animals were divided into three groups. Group 1 received Phenytoin alone, Group 2 received Rivaroxaban alone and Group 3 received Phenytoin and Rivaroxaban concomitantly. The treatment was given for 8 days and the blood samples were collected on day 1 and day 8. The samples were analyzed by HPLC. The results were showed no significant difference in the Pharmacokinetic parameters of Phenytoin in presence of Rivaroxaban. Whereas Rivaroxaban showed significant decrease in both Cmax and tmax in combination with Phenytoin. Phenytoin is a combined-gp inducer and strong CYP3A4 inducer therefore it may induce the metabolism of Rivaroxaban so it reduces the concentrations and increase the elimination rate. Based on the results obtained from pharmacokinetic study it was evident that the single dose of Rivaroxaban in combination with Phenytoin shows statistically significant interactions in its pharmacokinetic parameters.
In vitro and in vivo Evaluation of Pramipexole HCl Mucoadhesive Microspheres
Authors: Subbarao K. , Suresh G.
Published: March 2019

The study was aimed to design and develop the novel gastro retentive mucoadhesive Pramipexole microspheres using ionotropic gelation technique. Based on the results of Micromeretic properties confirmed that microspheres were free flowing with
good pack ability. The optimized M13 formulation displayed the % entrapment efficiency 96.07%, % yield 98.01%, swelling index 96.08% and Mucoadhesiveness was 95.42%. The in vitro drug release showed the sustained release of Pramipexole up to 99.16 ±
5.12% within 12 h. FTIR studies revealed incompatibility was not found between drug and excipients. SEM confirmed the particles were of spherical in shape. Optimized formulation (M13) were stable at 40°C ± 2°C/75% RH ± 5% RH for 6 months. In vivo
studies were performed and kinetic parameters like Cmax, Tmax, AUC0-t, AUC0-∞ and t1/2 were calculated. The marketed product Cmax (2.19 ± 0.01 ng/ml) was higher than optimized formulation (2.0 ± 0.01 ng/ml). The optimized formulation AUC0-t (20.15 ±
1.12 ng.hr/ml), AUC0-∞ (27.42 ± 1.16 ng.hr/ml) was significantly higher than that of marketed product AUC0-t (13.21 ± 1.26 ng.hr/ml) and AUC0-∞ (19.15 ± 1.13 ng.hr/ml) respectively. Which indicated the optimized formulation bioavailability was higher
than marketed product. Microspheres would be a promising drug delivery system which plays potentially significant role in pharmaceutical drug delivery in the efficient management of Parkinson’s disease.
Phytochemical Profiling of Amazonian Herbal Medicinal Products: The Role of Traditional Processing Methods
Authors: Tresca, Marco Soffiato Matteo Politi, Giorgia , Montes Richer Garay , Mendive Fernando
Published: March 2019

Research on traditional processing methods used to transform plants into medicines offers a valuable arena to investigate the correct formulation of herbal products. While scientific literature on traditional herbal medicines emphasizes the relevance of the taxonomical identification of the used species, the same rigor is not applied to recording the processing methods. In other words, attention is given to the ingredients, but not the recipes. This can not only jeopardize the quality of research on traditional herbal medicines, but also generate concerns once such medicines reach the global markets in compliance with modern manufacturing requirements, which are usually well far away from the traditional ones. In the present work, different traditional herbal medicines used in the region of San Martin, Peru, were analyzed by the means of UPLC-UV/DAD metabolite fingerprinting. Different extracts were prepared from same commercially available materials in order to test the effect of the recipes on the chemistry of the finished products. In particular, different plant parts and their status (fresh or dry), extraction solvents and decoction times were selected for metabolite comparisons between the extracts. In accord with literature data on others traditional pharmacopoeias, our results show how specific manufacturing steps can affect the chemistry of the finished products. Further efforts are necessary to evaluate the traditional herbal practices, whether understandable or not, with modern scientific approaches.
СОЦІАЛЬНА ІНФРАСТРУКТУРА ЯК ОСНОВА ФОРМУВАННЯ ЛЮДСЬКОГО ПОТЕНЦІАЛУ В СИСТЕМІ ЄВРОПЕЙСЬКИХ КООРДИНАТ
Authors: Lysenko Iryna
Published: March 2019

У статті розглянуто сутність та основні складові соціальної інфраструктури. Визначено, що соціальну інфраструктуру треба розглядати як єдину цілісну систему, діяльність якої спрямована на забезпечення гармонійного розвитку людини. Відзначено, що необхідною умовою підвищення рівня та якості життя населення є наявність розвиненої соціальної інфраструктури, головною метою якої є цілісний та всебічний розвиток людини, через створення комплексу життєво важливих благ, необхідних для розширеного відтворення людського потенціалу.
Особлива увага приділяється освітній, медичній та культурній підсистемам соціальної інфраструктури як базису формування людського потенціалу в системі європейських координат. Виявлено характерні ознаки системи освіти, медичної та культурної підсистеми соціальної інфраструктури як базису формування людського потенціалу; визначено заходи з їх наближення до стандартів ЄС.
Stolen Gods and Stolen Blessings? The Narrative Significance of Rachelâ€™s Theft in the Intertextual Mapping of the Jacob Cycle
Authors: Michael Matthew
Published: March 2019

Rachelâ€™s theft of her fatherâ€™s teraphim has generated little interest in modern studies of the Jacob cycle. The reason for this particular lack of attention comes partly from the obscurity of Rachelâ€™s theft, and the perceived insignificance of this theft in the mapping of the Jacob stories. However, this treatment of Rachelâ€™s theft often ignores the web of subtle intertextual connections between Rachelâ€™s theft and Jacobâ€™s earlier deception of his father. Drawing on these intertextual links, the present article engages the literary clues within the two stories that directly suggest the placement of Rachelâ€™s theft and deception of her father in the same character zone with the earlier story of Jacobâ€™s deception of his father. Consequently, the study provides a fresh engagement with an obscure theft by Rachel, and underscores its overall narrative significance to the Jacob cycle.
Ulusal Çeki̇rdek Eği̇ti̇m Programı Ai̇le Heki̇mli̇ği̇ Prati̇ği̇ndeki̇ Sorunları Kapsıyor mu?
Authors: BAŞER Aysel , KOLCU Giray , ŞAHİN Hatice
Published: March 2019

Amaç: Çalışmamızda aile hekimliği sisteminde aktif olarak çalışan hekimlerin sahada karşılaştıkları sorunlar ve UÇEP 2014’ün bu sorunları kapsama durumu değerlendirilmiştir.Gereç ve yöntem: Çalışmamız niteliksel araştırma deseninde tasarlanmıştır. Kesitsel tipteki araştırmada veri toplama aracı olarak “kritik olaylar tekniği” kullanılmıştır. Doğal çalışma ortamlarında müdahale olmaksızın kritik olaylar tekniği aracılığıyla toplanan hekimlerin karşılaştıkları olumlu ve olumsuz olayların betimleyici analizi yapılmıştır. Araştırma 2016 yılında T.C.S.B. Halk Sağlığı Kurumuna bağlı sözleşmeli aile hekimi olarak aktif görevde olan (aile hekimliği uzmanları ve pratisyen hekimler) 55 hekim ile yapılmıştır. Kritik olaylar tekniği ile veri toplama sürecinde aile hekimlerinden aile hekimliği pratiğinde yaşadıkları üç olumlu üç olumsuz olayı yazmaları istenmiştir. Bu olaylardan elde edilen veriler 6 kişilik bir analiz ekibi tarafından içerik analizine tabi tutulmuş, kategoriler geliştirilmiş ve açıklanmıştır.Bulgular: Veri setinde 299 olay (134’i olumlu,  165 ’si olumsuz) toplandı.  Bu çalışmada, hekimlerin anlattığı kritik olaylardan “Ruhum Yoruldu” metaforu ortaya çıkmıştır. Hekimlerin kendi bilimsel bilgi ve tıbbi başarılarından, meslektaş takdirinden içsel motivasyonlarının arttığı, sağlık müdürlüklerinin küçük bir yardımı ve takdiriyle de dışsal motivasyonlarının arttığı belirlenmiştir. Ulusal ÇEP 2014 ve araştırmamızda bulunan kategoriler birbirleri ile karşılaştırıldığında araştırmamızda elde edilen 12 alt kategoriden (motivasyon, hekim davranışı, hasta davranışı, hasta türü, hasta ve yakınları ile iletişim, sağlık çalışanları ile iletişim, başvuru nedeni, olay, otorite, örgütlenme,  bürokratik işlemler, ödül ve ceza) 3 başlığın (sağlık çalışanları ile iletişim, örgütlenme, otorite, ödül ve ceza içerisinde yer alan sağlık çalışanına şiddet ) temel hekimlik uygulamaları içinde yer almadığı görülmektedir. Özellikle ödül ve ceza başlığı altındaki hastaların sağlık çalışanını cezalandırma yöntemleri arasında sözlü ve fiziksel şiddetin şıkça yer aldığı görülmektedir. Ulusal ÇEP 2014 temel hekimlik uygulamaları başlığı altında hekimin kendi hak ve hukukunu koruması ile ilgili herhangi bir başlık yer almamaktadır. İletişim becerileri ve sağlık hukuku temel başlığı altında bu konuların ele alınması gerekmektedir. Ulusal ÇEP 2014 içerisindeki öğrenme düzeyleri ile olumlu ve olumsuz olaylar arasında herhangi bir ilişki bulunamamıştır.Sonuç: Araştırma bulguları aile hekimlerinin yaşadığı olumlu ve olumsuz olaylarla ilgili önemli bulgular ortaya koymuştur. Bu çalışmadan elde edilen veriler birinci basamakta yaşanan sorunların önemli bir kısmına ışık tutmaktadır. Ulusal ÇEP 2014’ün yeniden revize edilme aşamasında sahada yaşanan sorunlara çözüm açısından ve mezun olan öğrencinin sahada karşılaşacağı sorunlarla önceden müdahale açısından yeni başlıklar eklenmesine katkı sağlayacaktır.
An Analysis on Readability of English Reading Texts With Automated Computer Tool
Authors: Yulianto Yulianto
Published: March 2019

Selecting appropriate textbook to the students is important because textbook have dominant role in the success of foreign language teaching and learning. The purpose this article is to analyze the readability level of English reading texts with automated computer tools. There are eight reading texts that will be analyzed in this qualitative study.  The data and source of data of this research were adopted from an English textbook entitled Pathway to English 2 Textbook for the Eighth Grade of Junior High School Students Published by Erlangga. The results reveal that only 1 text was appropriate for seven or eight grade of Junior High School students. There were 6 texts appropriate elementary students. And there was 1 text suitable for Senior High School students.
TMB-iBIOMES: An iBIOMES-Lite Database of Nucleosome Trajectories and Meta-Analysis
Authors: Sun Ran , Li Zilong , Bishop Thomas C.
Published: March 2019

Here we introduce our TMB-iBIOMES database which serves as both a reference for future comparative, on-demand simulations of nucleosomes and a demonstration of iBIOMES-Lite as a tool for managing a laboratory's simulation inventory. TMB-iBIOMES contains over 20 microseconds of all atom molecular dynamics simulations for over 500 different realizations of the nucleosome. For every simulation, the original input, output, de-watered trajectories, RMSD, and DNA helical parameter data are provided. Closely related simulations are grouped together, and a meta-analysis of each group is provided. The data can be navigated in a file browser format or downloaded directly with command line tools. Collectively the simulations provide a novel view of nucleosomal DNA. Compared to DNA free in solution, DNA on the nucleosome is not highly deformed or tightly restricted as determined by DNA helical parameter analysis. The overall conformation is restricted to a specific left-handed super helix, but the range of conformations explored by individual base pairs is larger than that observed for DNA free in solution.
Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation
Authors: Tseng Alexander M , Mahnke Amanda H , Wells Alan B , Salem Nihal A , Allan Andrea M , Roberts Victoria HJ , Newman Natali , Walter Nicole AR , Kroenke Christopher D , Grant Kathleen A , Akison Lisa K , Moritz Karen M , Chambers Christina D , Miranda Rajesh C ,   Collaborative Initiative on Fetal Alcohol Spectrum Disorders
Published: March 2019

Prenatal alcohol exposure (PAE), like other pregnancy complications, can result in placental insufficiency and fetal growth restriction, although the linking causal mechanisms are unclear. We previously identified 11 gestationally elevated maternal circulating miRNAs (HEamiRNAs) that predicted infant growth deficits following PAE. Here, we investigated whether theseHEamiRNAs contribute to the pathology of PAE, by inhibiting trophoblast epithelial–mesenchymal transition (EMT), a pathway critical for placental development. We now report for the first time that PAE inhibits expression of placental pro-EMT pathway members in both rodents and primates, and thatHEamiRNAs collectively, but not individually, mediate placental EMT inhibition.HEamiRNAs collectively, but not individually, also inhibited cell proliferation and the EMT pathway in cultured trophoblasts, while inducing cell stress, and following trophoblast syncytialization, aberrant endocrine maturation. Moreover, a single intravascular administration of the pooled murine-expressedHEamiRNAs, to pregnant mice, decreased placental and fetal growth and inhibited the expression of pro-EMT transcripts in the placenta. Our data suggest thatHEamiRNAs collectively interfere with placental development, contributing to the pathology of PAE, and perhaps also, to other causes of fetal growth restriction.
NUMERICAL CALCULATION OF THE HYDROLIQUID LEAKAGE THROUGH THE RADIAL CLEARANCE OF THE CONNECTED ELEMENTS ON THE TOWER CRANE HYDROCILINDER
Authors: Potakhov D. A. , Vatulin Ya. S.
Published: March 2019

Introduction. The authors present the numerical calculation of the hydro-liquid leakage throughthe radial clearance of the “piston - hydraulic cylinder” conjugate node on the basis of determiningthe sealing elements’ resource of the tower crane hydraulic cylinder.Materials and methods. The authors use the method of mathematical modeling, which makes it possible to model the containing elements’ interaction of different physical nature on the unified methodological basis. Moreover, the paper presents such simulation systems as Simulation (finite element method), Flow Simulation (finite volume method) of the SolidWorks CAD program and Simulink Matlab with expansion packs.Results. As a result, the authors demonstrate the three-dimensional and irregular cross-section conjugation model of the radial clearance in the “piston - hydraulic cylinder” conjugate node. In addition, the authors propose the calculating method of the hydraulic cylinder tightness. Such method establishes the following scheme: “load on the hydraulic cylinder —number of operating cycles — uneven radial clearance between the piston and the liner — amount of fluid leakage — shrinkage of the rod”.Discussion and conclusions. The results of the research make it possible to increase the reliability of the power hydraulic cylinders of the road construction machines and equipment.
SOLVING THE PROBLEMS OF THE SUBMERGENCE IN URBAN CONSTRUCTION SPHERE
Authors: Sologaev V. I.
Published: March 2019

Introduction. The submergence by underground water remains one of the problems in urban construction. It is also associated with the movement of groundwater under buildings and structures. Such processes are non-stationary and their calculation is complex. The paper begins the series of researches on the methodology for solving problems of filtering groundwater while protecting against flooding in urban construction by using an operator method. Oliver Heaviside began the practical application of mathematical operators for solving engineering problems. The operator method with Laplace transformations was used. It was shown how, with the help of the Internet and Maxima program, it is easy to make inverse Laplace transformations.Methods and materials. The author considered the decision on the submergence of the city road in the presence of a dome watering under asphalt pavement in the dirt road foundation. At the same time, for filtration problems of such type, the author took into account the compaction of the engineering zone of the soil under the road. The paper showed how to solve the complex non-stationary problem of spreading the dome of the flooding under the city road. The technology of the solution is presented not only with all the mathematical details of the operator method, but also provided with new physical representations. Such an original approach, by the author’s opinion, would help better understanding of the flooding process physics in urban construction. Moreover, it would allow solving problems of protection against flooding by a new, more efficient way, taking into account the real non-stationary processes of filtration of groundwater in built-up areas.Discussion. As a result, the author presents anew statement of the operator method for solving the submergence specific problem in urban construction. First, a specific example demonstrates how to use the Internet and the license-free Maxima program. In this case, the simplest  case is taken, in the form of the electricity and filtration analogy. Then the author considers the filtration spreading of the domed man-made groundwater beneath the city road. Therefore, the paper demonstrates new solutions for non-stationary filtration of groundwater in the engineering zone, which are also compared with the world practice results.Conclusions. The author presents the methodology for solving unsteady groundwater filtration problems for the submergence protection in urban construction by using the operator method and Laplace transformations. Such decisions make it possible to obtain convenient engineering formulae, by which groundwater levels, substantiate practical solutions and measures for protection against submergence in urban construction could be found. The author intends to further development of such scientific ideas and solutions for submergence protection in the built-up areas.
INFLUENCE OF FREE DRAWINGS TO IMPROVE CREATIVITY IN 5TH GRADER CHILDREN IN MI MU'AWANAH AL-HASYIMIYAH
Authors: Laili Siti Indatul , Yuniarti Enny Virda
Published: March 2019

Free drawing on children provides a vast opportunity to explore in order to fulfill curiosity. By drawing the child freely express his ideas through fantasy. Safety and freedom are important conditions for the growth of creativity. The objective of the study was to prove the effect of free drawing on the improvement of creativity in 5th grader children in MI Mu'awanah Al-Hasyimiyah. This research design used one group pre-posttest design. The population of this research were all 5th graders in MI Mu'awanah Al-Hasyimiyah as many as 26 children. The sample of this research was all 5th graders in MI Mu'awanah Al-Hasyimiyah as many as 26 children taken with total sampling. Measurement tool used by the questionnaire to assess creativity. Research was on 15th â€“ 27thJuly 2017. Statistic test used Wilcoxon Sign Rank Test. The results showed that all 26 (100%) of respondents had positive creativity and Ïcount 0,014 = and a table = 0,05. It meant that there was a free drawing effect on the increase of creativity in 5th grader children in MI Mu'awanah Al-Hasyimiyah. When a child draws, the child will perform activities of crossing out, scratching, and color freely. Thus, able to create various ideas and will give satisfaction for children. New ideas as pieces of creative thinking for children.

Keywords: child, creativity, free drawing
The Relationship Between Perceptions About Consuming Cigarettes With The Intention Of Smoking In Adolescents At Upt Smpn 1 Bangsal Kabupaten Mojokerto
Authors: Ibnu Faisal
Published: March 2019

dear my editor

this is my journal. thanks
THE EFFECT OF RED SESBANIA (SESBANIA GRANDIFLORA L.PERS) LEAVES EXTRACT ADMINISTRATION ON THE DECREASE OF LEUKOCYTE LEVEL IN POST-PARTUM MICE (MUS MUSCULUS) INFECTED WITH STREPTOCOCCUS AGALACTIAE
Authors: MARDIANA HEPPY RINA , Sari Surya Mustika , LESTARI YUFI ARIS , SUPRIANI ANIK , ROSYIDAH NANIK NUR , IDAYANTI TITIEK , HERLINA HERLINA
Published: March 2019

Introduction: Maternal Mortality Rate (MMR) is indicator of public health degree. The cause of maternal mortality is postpartum infection. Streptococcus agalactiae bacterium contributes to postpartum infection incidence through vaginal or reproductive organ injury. Infection incidence is characterized with the increased level of leukocyte. The treatment of post-partum infection is done by administering antibiotics. Red sesbania leaves contains active substance that can inhibit the microbial growth. Objective: This research aimed to find out the effect of red sesbania leaves extract administration as antimicrobial agent to decrease leukocyte level in post partum mice (Mus musculus) infected with Streptococcus agalactiae. Method: The method employed was true experimental one with post test control group design, by dividing postpartum mice into 4 groups: one control group and three treatment groups at doses of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. All 0-12 hour post partum mice were inoculated with Streptococcus agalactiae bacterium. The administration of 1 ml red sesbania leaves extract in treatment group was conducted 2 hours after the bacterial administration at doses of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Result: The result of analysis shows p < 0.05, indicating that the decrease of leukocyte level in all treatment groups (P1, P2, P3). Conclusion: Red sesbania leaves extract has antimicrobial activity that can reduce leukocyte level, thereby can be used as an alternative therapy to decrease maternal mortality rate due to post-partum infectin.

KEYWORDS

Red sesbania leaves extract, postpartum mice, leukocyte level, Streptococcus agalactiae.
INFLUENCE OF DYSMENORRHEA GYMNASTIC ON MENSTRUAL PAIN TO 8TH GRADE STUDENTS OF SMPN 2 SOOKO DISTRICT MOJOKERTO
Authors: Idayanti Titiek , Su'idah Hartin , Haryanto Devi Kharismanda , Sari Surya Mustika , Mardiana Heppy Rina , Virgia Vera
Published: March 2019

Light exercises (gymnastics) are highly recommended to reduce dysmenorrhea but during this adolescent only use medical therapy drugs to reduce the pain felt. The purpose of this study to determine the effect of dismal gymnastics on menstrual pain in adolescent girls 8th grade of SMPN 2 Sooko Mojokerto regency. The research design is Pre-Experimental Design with Static Group Comparison approach. The research variables are dysmenorrhea gymnastic as independent variable and dysmenorrhea pain as the dependent variable. The study population is all students of 8th grade who experienced menstrual pain in SMPN 2 Sooko as many as 54 people. A sample of 48 students taken with cluster sampling technique. Data were collected with pain scale observation sheets, and the results were tested with the Wilcoxon test. The results of Wilcoxon test showed that there was the influence of discharging gymnastics on menstrual pain in 8th grade of SMPN 2 Sooko Mojokerto. which is indicated by Ï = 0,000 and Î± = 0,05 so that Ï <Î± then H0 is rejected and H1 is accepted. Gymnastics dysmenorrhea with several movements that can provide a sense of comfort and calm so that it can affect the response of pain experienced by respondents. Students are expected to apply dysmenorrhea gymnastics to be able to relieve the pain of dysmenorrhea pain experienced so that the pain experienced can be reduced and respondents not only rely on pharmacological drugs in reducing the pain experienced.
POTENCY WATER STEW OF AVERRHOA BILIMBI L FOR ANTIHYPERTENSIVE
Authors: Lestari Indah - , Melania Anissa , Prasetyo Budi
Published: March 2019

Hypertension is often referred to as a "silent killer", because patients often do not feel any significant symptoms. Uncontrolled hypertension has an increased risk of severe health problems, but the patient is less concerned about taking the drug regularly. AVERRHOA BILIMBI L contains about 6 mg/kg total of volatile compounds also oxalate compounds; oils evaporated, phenol, flavonoid and pectin, amino acids, citric acid, phenolics, potassium ions.It plays a role in decreasing blood pressure. The research objective proved the effectiveness of AVERRHOA BILIMBI L against changes in hypertensive blood pressure. The research design was pre-experiment one group pre-posttest approach. Populationwas all of hypertension patient in Sumbergirang Village and Karang Tengah Village as many as 80 people. Sample was hypertension patient who fulfill criteria of 60 people, with purposive sampling. The independent variable was the provision of AVERRHOA BILIMBI L water stew and the dependent variable was the hypertension blood pressure change. The results showed significant changes in blood pressure, in which most respondents showed systole and diastolic results, in the category of mild hypertension (67% of respondents) and moderate (47% of respondents). The result of paired sample T-test statistic showed significant = 0,000, so water stew of AVERRHOA BILIMBI L effectively against the decrease of hypertension blood pressure. Potassium plays a role in enlarging the size of endothelial cells and increasing the production of nitric oxide that will trigger dilation reactions and vascular reactivation that will lower blood pressure.

Keywords: AVERRHOA BILIMBI L, Hypertension, Blood Pressure.
PROGRESSIVE MUSCLE RELAXATION EFFECT ON THE LEVEL ANXIETY of CANCER PATIENTS UNDERGOING CHEMOTHERAPY
Authors: Yuniarti Enny Virda , Rahmawati Ima
Published: March 2019

The physical effects of cancer and its therapy can lead to an unpleasant emotional experience. Long-term treatment of chemotherapy and the presence of perceived side effects can cause anxiety. One of the nonpharmacological measures to overcome this anxiety is the relaxation of Progressive Muscle Relaxation therapy. to know the effect of relaxation Progressive Muscle Relaxation on the level of anxiety in cancer patients who underwent chemotherapy. Independent Variables are Progressive Muscle Relaxation and Dependent Variables of Anxiety Level. This research design uses Pre- Experiment with Pretest-Posttest approach design. Sample amounted to 30 people. Sampling technique Purposive Sampling. The tool used in the HRS-A (Hamilton Rating Scale-Anxiety) questionnaire. The research was conducted from March to April 2017 at Leprosy Hospital SumberGlagahPacet, Mojokerto. Progressive Muscle Relaxation performed one up to two times for 3 weeks with a duration of 15 minutes per session. The test statistic used is to use the Wilcoxon Rank Test test. Ï = 0.046 and Î± = 0.05 so that means H0 rejected and H1 accepted which means there is influence progressive muscle relaxation to the level anxiety cancer patients who underwent chemotherapy at Leprosy Hospital Pacet, Mojokerto. Progressive Muscle Relaxation is recommended as one of the non-pharmacological complementary therapies because this relaxation technique is easy to do and does not cost.
THE EFFECT OF TOUCH THERAPY ON NUTRITION STATUS AND THE DEVELOPMENT OF INFANTS
Authors: Laili Siti Indatul , Ratnaningsih Tri , Peni Tri
Published: March 2019

Infancy started from 0-12 months which was characterized by rapid growth and physical changes accompanied by changes in nutritional needs to optimize the growth and development of the baby by providing touch, motion and other stimulation combinations. The research was purposed to know the effect of Touch Therapy on nutritional status and development on infants in Gayaman Village, Mojokerto Regency. The research design used one group pre-post test design. The population were infants in Gayaman Village, Mojokerto Regency, 70 respondents. The sample was 69 infants (0-18 months) in Gayaman Village, Mojokerto Regency, who were obtained by purposive sampling. Measuring instruments were used to assess nutritional status and denver II forms to assess the progress. The research was done on July 28 to August 25, 2018. Statistical test used Wilcoxon Signed Rank Test. The results showed that nutritional status before being given touch therapy was normal as many as 57 (83%) respondents, and the development after being given touch therapy increased to 66 (96%) respondents. The development before being given touch therapy was normal as many as 27 (39%) respondents with Ï = 0.003. This showed that there was an effect on touch therapy to their nutritional status. The nutritional status after being given a touch therapy increased to 57 (83%) respondents with Ï = 0.008. This showed that there was an effect of touch therapy on their development. Massaging was a fun way to help strengthening the bond between mother and child. This was the key to baby's development.
KEPADATAN OPTIMUM UNTUK MENUNJANG TINGKAT KELANGSUNGAN HIDUP BENIH IKAN BANDENG (Chanos chanos) PADA TRANSPORTASI SISTEM TERTUTUP
Authors: Syamsunarno Mas Bayu , Maulana Muh Kholik , Indaryanto Forcep Rio , Mustahal Mustahal
Published: March 2019

Abstract: This research aims to determine the optimum density in closed system transportation of milkfish juvenile. Milkfish juveniles used in the research had an average weight 1.48ÃÂ±0.12 g. The study consisted of several stages, namelydetermining the ability to fast fish, determining the level of oxygen consumption, determining the rate of excretion of total ammonia nitrogen and determining the optimum density in transportation for 48 hours.The treatments were performed differences in the density of 100, 150, 200, and 250 fish/L using polyethylene plastic size 35x50 cm and styrofoam size of 75 Ãâ 43 Ãâ 40 cm.The results showed the seed fish can survive and swim actively for 7 days without feeding with oxygen consumption rate as much as 2640 mgO2 and TAN excretion rate 0.1200 mg/L. The different treatment of density had an effect on the survival rate of milkfish juvenile. The optimal density for transportation of milkfish juvenile size 1.48 ÃÂ± 0.12 g in a closed transportation system with a time of 48 hours is 150 juvenile/L with a 100% survival rate. At the density 250 juvenile/L, the can be done with a long time of 30 hours and resulted in a survival rate above 99%. ÃÂ Keyword: Chanos chanos, Density, Transportation closed system, Survival rate, Water QualityÃÂ Abstrak: Penelitian ini bertujuan untuk menentukan kepadatan optimal dan lama waktu dalam transportasi sistem tertutup benih ikan bandeng.Benih ikan bandeng yang digunakan memiliki bobot rata-rata 1,48ÃÂ±0,12g. Penelitian terdiri dari beberapa tahap, yaitu penentuan ketahanan ikan tanpa diberi makan, tingkat konsumsi oksigen, laju ekskresi total amoniak nitrogen dan kepadatan optimal benih ikan bandeng dalam transportasi selama 48 jam. Perlakuan yang dilakukan perbedaan kepadatan yaitu 100, 150, 200, dan 250 ekor/L dengan menggunakan plastik polyetylen (PE) ukuran 35x50 cm dan styrofoam ukuran 75Ãâ43Ãâ40 cm.Hasil penelitian menunjukkan benih ikan bandeng mampu bertahan hidup dan berenang aktif selama 7 hari pemuasaan ikan dengan tingkat konsumsi oksigen sebanyak 2640 mgO2 dan laju ekskresi TAN 0,1200 mg/L.Perlakuan perbedaan kepadataan berpengaruh terhadap kelangsungan hidup benih ikan bandeng.Kepadatan optimal untuk transportasi benih ikan bandeng ukuran 1,48ÃÂ±0,12 g/ekor pada sistem transportasi tertutup selama 48 jam adalah 150 ekor/L dengan tingkat kelangsungan hidup 100%. Pada kepadatan 250 ekor/L, transportasi dapat dilakukan dengan lama waktu 30 jam dan menghasilkan tingkat kelangsungan hidup di atas 99%.ÃÂ Kata Kunci: Ikan bandeng, Kepadatan, Kualitas Air, Transportasi sistem tertutup, Tingkat Kelangsungan Hidup
SIKAP KONSUMEN TERHADAP PRODUK UNGGULAN SEKTOR MAKANAN KOTA MATARAM (STUDI PADA PRODUK TAHU ABIAN TUBUH)
Authors: Ilhamuddin H M , Nururly Hj Santi , Rusminah Rusminah
Published: March 2019

This research is aimed at determining the attitude of consumers towards one of the superior products of Mataram city, that is tahu Abian Tubuh. The research is descriptive which using sample survey method. In order to answer the problem proposed, the analytical tool is Ideal-Point Model. The model measures a difference between what is desired and what is perceived by consumers. The result of this study shows that consumer attitudes are very good. It is indicated by attitude value of 13,764 which is lied at the highest interval in linear numerical scale 0 < Ab < 22,56 (very good). It means that the Tahu Abian Tubuh is in accordance with consumer’s desire. Key words: consumer’s attitude, tahu Abian Tubuh.
Perancangan dan Implementasi Aplikasi Pendaftaran Online PORKOTA Berbasis Client Server Menggunakan Web dan Android
Authors: Ariyanti Dyah
Published: March 2019

Comitte nasional sports of Indonesia is the organization that focus on sport. Every two years, Probolinggo's KONI hold city sports week activity that specially for elementary and junior hight school students. In every registration process Porkota's participant currently it is still done manually which causes the registration process to occur a lot of error and requirs a longer time. Along with the development of technology, an online registration system is needed to simplify the registration process and prevent errors from occurring. The PORKOTA registration application consists of web and android applications. The android application is used by the school to register and the web application is used by KONI to make data changes, delete data and print data. Design of PORKOTA registration process system is described in the Unified Modeling Language (UML). Then develop a client server based application using web and android with the System Development Life Cycle (SDLC) method as a solution to these problems. The results of this study is the creation of a client server-based PORKOTA online registration application using web and android. This application is expected to help the school and the Probolinggo's KONI in facilitating the PORKOTA registration process
КЛАСИФІКАЦІЯ РІЗНОВИДІВ КОНСТРУКТИВНО-ДЕКОРАТИВНИХ ЕЛЕМЕНТІВ КУРТОК ДЛЯ ПІЛОТІВ ВІЙСЬКОВОЇ АВІАЦІЇ
Authors: Рубанка А. І. , Токар Г. М. , Стельмах М. Д. , Семененко В. В. , Северіна Є. А.
Published: March 2019

To analyze and to systematize the varieties of design solutions for individual design and decorative elements and units during the manufacturing of the protective field coats for military aviation pilots. The system and structural analysis of the components of the protective field coats for pilots is used; the activity of military personnel is theoretically analyzed and estimated.
ОЦІНКА РОЛІ КОСТЮМА В СИСТЕМІ РЕКРЕАЦІЙНО-ТУРИСТИЧНИХ АТРАКЦІЙ
Authors: Артеменко М. П.
Published: March 2019

The research aims to assess the role of the costume in the processes of recreational and tourist attractions and determine the most influential characteristics of it to attract attention and memorize visitors. The research contains a critical analysis of publications on selected topics, is based on a sociological survey, statistical processing of data. The graphical interpretation of the results of the survey was used, which allowed to assess the emotional impact of the costume on creating an atmosphere of recreational and tourist activities.
ХУДОЖНЬО-КОМПОЗИЦІЙНЕ ФОРМОУТВОРЕННЯ КОРПОРАТИВНОГО ОДЯГУ «УКРЗАЛІЗНИЦІ»: ЕСТЕТИЧНИЙ АСПЕКТ
Authors: Колосніченко О. В. , Приходько-Кононенко І. О. , Остапенко Н. В. , Колосніченко М. В.
Published: March 2019

The goal of the research is to develop the bases of artistic composite form creation and stylistic series aesthetics of  «Ukrzaliznytsia» employees’ uniforms. There have been considered the peculiarities of approaches to the uniform (special purpose clothes) design as an integral part of the material culture, compliance with the provision of its aesthetic, identification, stylistic and image corporation requirements.
ДЕКОР НАРОДНОГО ВБРАННЯ ОПІЛЛЯ: ТЕХНІКИ ВИКОНАННЯ
Authors: Куцир Т. В.
Published: March 2019

In the paper décor creation techniques of Opillia folk costume of the last third of the XIX – the first half of the XX centuries based on items from Ukrainian and foreign museums, literary, achieve and field sources are analyzed. A systematic approach to the chosen object, formal and art methods of analysis are used. It is permit the most fully to reveal the décor features created by different techniques.
Кислотно-основные и антиоксидантные свойства комплексов фитиновой кислоты и ксимедона в растворе
Authors: Сидорова Марта Валерьевна , Мартусевич Андрей Кимович , Соловьёва Анна Геннадьевна , Перетягин Сергей Петрович , Дорофеева Анастасия Романовна , Нистратова Лидия Николаевна , Мельникова Нина Борисовна
Published: March 2019

Методами ИК-, УФ-, 1H и 13C ЯМР спектроскопии и потенциометрическим титрованием показано, что взаимодействие миоинозитол гексакисфосфата (InsP6H12) и 1-(β-оксиэтил)-4,6-диметил-1,2-дигидро-2-оксопиримидина (ксимедона) в водном растворе протекает через стадию переноса протона с образованием ионных и H-ассоциированных комплексов. Результаты исследований in vitro в плазме крови человека показывают синергетический эффект антиоксидантного действия и активации супероксиддисмутазы фитиновой кислоты и ксимедона в комплексах ксимедона фитата.
Конъюгаты антрациклиновых антибиотиков с макромолекулами
Authors: Тевяшова Анна Николаевна
Published: March 2019

В обзоре рассмотрены достижения последних лет в области создания конъюгатов на основе антрациклиновых антибиотиков и макромолекул. Конъюгаты классифицированы в зависимости от размера макромолекулы и наличия или отсутствия в ней структурного элемента, отвечающего за селективное связывание (взаимодействие) с определенными структурами клеточной мембраны или цитоплазмы.
Различие в цереброваскулярных и противоишемических эффектах дофамина, докозагексаеноилдофамина и конъюгата ГАМК с докозагексаеноилдофамином
Authors: Мирзоян Рубен Симонович , Ганьшина Т. С. , Топчян А. В. , Хайлов Н. А. , Курдюмов И. Н. , Ковалёв Г. И. , Зимин И. А. , Фирстова Ю. Ю. , Васильева Е. В. , Грецкая Н. М. , Безуглов В. В.
Published: March 2019

Проведено сравнительное изучение влияния дофамина, синтетических докозагексаеноилдофамина (DHA-DA) и конъюгата ГАМК с докозагексаеноилдофамином (OXL1220) на кровообращение интактного и ишемизированного мозга. Выявлены различия в цереброваскулярных и противоишемических эффектах исследованных соединений. Дофамин и DHA-DA усиливают кровоснабжение интактного и ишемизированного мозга, которое сопровождается выраженной гипертензивной реакцией. Последний при этом проявляет свойства ингибитора дофаминового транспортёра с IC50 = 29 мкМ, но практически неактивен как лиганд дофаминовых рецепторов. OXL1220 оказывает избирательное сосудорасширяющее действие на кровоснабжение мозга, подвергнутого глобальной преходящей ишемии. Причём лишь OXL1220 конкурирует за места специфического связывания [3H]-габазина на ГАМКА-рецепторах коры мозга крыс in vitro. Следовательно, включение в структуру DHA-DA нейромедиатора — ГАМК — изменяет дофаминергический характер активности вещества на ГАМК-ергический в отношении тонуса сосудов ишемизированного мозга.
Получение микронизированной субстанции стероидного препарата мецигестон и оценка его биодоступности
Authors: Назаров Андрей Константинович , Заварзин И. В. , Назаров Г. В. , Аксёнов А. В. , Левина И. С.
Published: March 2019

С применением нанораспылительной сушилки NANO Spray dryer BUCHI B-90, Швейцария, позволяющей работать с органическими растворителями в замкнутом цикле, получены микрокристаллы 6α-метил-16α,17α-циклогексапрегн-4-ен-3,20-диона (мецигестона), отличающиеся от исходной субстанции уменьшенными размерами и измененной морфологией кристаллов. На белых беспородных крысах исследована биодоступность исходной кристаллической и микронизированной субстанции мецигестона при пероральном введении. Для извлечения мецигестона из сыворотки крови крыс использовали жидкость-жидкостную экстракцию, коэффициент извлечения при этом составил 64 %. Предел обнаружения исследуемой субстанции составил 0,08 нг/мл. Определение содержания неизмененного мецигестона в экстрактах биопроб проводили методом ВЭЖХ с применением масс-спектрометрии высокого разрешения. Установлено, что по сравнению с исходной субстанцией биодоступность микронизированного мецигестона повышается в 7,5 раз.
Влияние N,N’-замещенных пиперазинов на цитолиз
Authors: Веселкина Ольга Сергеевна , Соловцова Ирина Леонидовна , Петрищев Николай Николаевич , Галебская Людвига Вячеславовна , Боровитов Максим Евгеньевич , Нилов Денис Игоревич , Соловьева Марина Алексеевна , Воробьев Евгений Александрович , Леньшина Ксения Сергеевна
Published: March 2019

Исследована гемолитическая активность N,N’-замещенных пиперазинов, а также их влияние на гемолитический процесс, инициированный облучением (красный светодиод, 653 нм) в присутствии фотосенсибилизатора радахлорин (ООО «РАДАФАРМА», Россия), и на комплементзависимый гемолиз. Все соединения в исследованном диапазоне концентраций (0,15 – 3,0 мМ) не вызывали лизиса эритроцитов человека, но обнаруживали дозозависимое ингибирование фотогемолиза, проявляющееся в увеличении времени 50 % лизиса клеток. На параметры лизиса эритроцитов активированным комплементом производные пиперазинов существенного влияния не оказывали. Следовательно, антигемолитический эффект N,N’-замещенных пиперазинов обусловлен их антиоксидантным действием.
Синтез и оценка влияния 2,4-диметоксифенилбигуанида на активность глутатионовой антиоксидантной системы в сердце и сыворотке крови крыс при экспериментальном ревматоидном артрите
Authors: Сафонова Ольга Анатольевна , Попова Т. Н. , Крыльский Е. Д. , Таныгина Е. С. , Кирилова Е. М.
Published: March 2019

Разработана методика синтеза 2,4-диметоксифенилбигуанида, отобранного с помощью компьютерной программы прогнозирования биологической активности PASS, и проведена оценка влияния этого нового бигуанидинового производного на содержание восстановленного глутатиона, активность глутатионпероксидазы, глутатионредуктазы и глутатионтрансферазы в сердце и сыворотке крови крыс с экспериментальным ревматоидным артритом. При введении животным с патологией тестируемого соединения выявлено изменение исследуемых параметров в сторону контрольных значений, что может быть объяснено с точки зрения реализации его кардиопротекторного и антиоксидантного действия. Данные, полученные в ходе работы, могут быть применены при разработке новых способов профилактики и лечения указанного патологического состояния.