bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantification and Flow Simulation of Ecosystem Service Supply and Demand in the Yellow River Delta High-Efficiency Eco-Economic Zone
Authors: Liu Wenjun , Ma Xiangyi , Sun Qian , Qi Wei , Yu Xinyang
Published: October 2024

The identification of supply and demand areas for ecosystem services (ES) and the simulation of ES flows are essential for optimizing ESs to achieve socio-economic sustainable development. However, the selection of investigation methods and simulation model remains a persistent challenge. This study selected the Yellow River Delta High-Efficiency Eco-Economic Zone in China as the case study area and assessed the habitat quality and carbon sequestration services for 2000, 2010, and 2020. The quantile regression method was employed to quantify the impacts of land use structure on balancing the supply and demand of ESs. The minimum cumulative resistance model, circuit corridor model, and wind direction model were utilized to analyze changes in flux and flow direction of ESs’ supply and demand. The results demonstrated that the following: (1) the supply of ESs generally increased, with a significant rise in demand for carbon sequestration service and a declining trend in habitat quality service demand. (2) A clear spatial mismatch existed between the supply and demand of ESs. (3) The impact of land use structure on the balance of ES supply and demand is complex. (4) Habitat quality and carbon sequestration services exhibited distinct spatial clustering patterns. (5) The flow patterns of habitat quality service were characterized by specific supply and demand areas, with corridors and pinch points indicating the flow paths and potential barriers; not all demand areas for carbon sequestration service can be satisfied due to variations in service levels and geographical distance. The innovation of this study lies in the following aspects: (1) it acknowledges the uniqueness of ecosystem services, with a focus on assessing habitat quality and carbon sequestration services; (2) it precisely quantifies the flow of ecosystem services, analyzes the spatial dynamics of service flows, and investigates the impact of changes in land-use structure on these flows; (3) it strengthens the correlation between the supply and demand of ecosystem services and socio-economic activities, uncovers the contradictions between supply and demand along with their underlying causes, and proposes effective strategies for resolution. The findings can provide theoretical and methodological references for the optimization of ES.
The Legal Challenges of Realistic and AI-Driven Child Sexual Abuse Material: Regulatory and Enforcement Perspectives in Europe
Authors: Parti Katalin , Szabó Judit
Published: October 2024

Although the escalation in online child sexual abuse material (CSAM) is not a novel problem, recent digital proliferation has brought about new alarming challenges in addressing the issue. CSAM poses significant risks to children and society in general, the most serious being the long-lasting harmful effects on depicted victims. The already distressing problem is exacerbated by the worldwide appearance and spread of AI-driven or virtual CSAM, as AI offers a fast and increasingly profitable means for the sexual exploitation of children. The paper aims to provide a comprehensive review of current legislative measures focusing the European Union for combating online CSAM. With a particular focus on AI-driven CSAM, we will systematically evaluate the effectiveness and applicability of these regulations in addressing virtual CSAM. The paper will conclude with policy recommendations to address identified gaps in the European legislative framework concerning virtual CSAM.
Experimental Assessment of Corrosion Properties for Materials Intended for Heavy Crude Processing
Authors: González-Durán Raúl , Rodríguez-Prieto Alvaro , Camacho Ana María , Peña-Ballesteros Darío Y. , Serna Aníbal
Published: October 2024

Heavy crude oil processing presents significant challenges owing to its complex composition and requirement for processing conditions, which increase the process safety risk in crude processing units, such as fixed equipment, for instance pressure vessels and pipes. The aim of this work is to evaluate the influence of heavy crude oils named A and B and the effect of sulfur-rich compounds and organic acids on the performance at high temperatures of three metallic alloys (5Cr-1/2Mo/ASTM A335GP5, X6CrNiMoTi17122/AISI-SAE 316Ti and Ni66.5Cu31.5/Monel 400) and propose an alternative to be used in pressure vessels and piping in refineries. This work was based on the need to understand the corrosivity of two heavy crude oils (A and B) from eastern Colombia in three materials, evaluated at three temperatures (200 °C, 250 °C and 300 °C) under the same conditions of pressure (200 psi) and rotation velocity (600 rpm) in a dynamic autoclave to simulate atmospheric conditions and conditions in vacuum refinery towers. An understanding of how these factors interact with the fundamental principles of corrosion kinetics is essential for developing an effective corrosion mitigation strategy. The results were interesting for applications requiring high corrosion resistance. X6CrNiMoTi17122/AISI-SAE 316Ti is a solid candidate for this application, with corrosion rates of 0.2 to 0.87 mpy. Ni66.5Cu31.5/Monel 400 exhibited significant corrosion rates up to 74.89 mpy, especially at higher temperatures (300 °C). 5Cr-1/2Mo/ASTM A335GP5 showed a generally moderate corrosion rate (2.04–5.57 mpy) in the evaluated temperature range.
Investigation of the Mechanical Properties of Reinforced Calcareous Sand Using a Permeable Polyurethane Polymer Adhesive
Authors: Cao Dingfeng , Fan Lei , Huang Rui , Guo Chengchao
Published: October 2024

Calcareous sand has been widely used as a construction material for offshore projects; however, the problem of foundation settlement caused by particle crushing cannot be ignored. Although many methods for reinforcing calcareous sands have been proposed, they are difficult to apply on-site. In this study, a permeable polyurethane polymer adhesive (PPA) was used to reinforce calcareous sands, and its mechanical properties after reinforcement were investigated through compression creep, direct shear, and triaxial shear tests. The reinforcement mechanism was analyzed using optical microscopy, CT tomography, and mercury intrusion porosimetry. The experimental results indicate that there is a critical time during the compression creep process. Once the critical time is surpassed, creep accelerates again, causing failure of the traditional Burgers and Murayama models. The direct shear strength of the fiber- and geogrid-reinforced calcareous sand reinforced by PPA was approximately nine times greater than that without PPA. The influence of normal stress was not significant when the moisture content was less than 10%, but when the moisture content was more than 10%, the shear strength increased with an increase in vertical normal stress. Strain-softening features can be observed in triaxial shear tests under conditions of low confining pressure, and the relationship between the deviatoric stress and strain can be described using the Duncan–Chang model before softening occurs. The moisture content also has a significant influence on the peak strength and cohesive force but has little influence on the internal friction angle and Poisson’s ratio. This influence is caused by the different PPA structures among the particles. The higher the moisture content, the greater the number of pores left after grouting PPA.
Design of a Path-Tracking Controller with an Adaptive Preview Distance Scheme for Autonomous Vehicles
Authors: Park Manbok , Yim Seongjin
Published: October 2024

This paper presents a method to design a path-tracking controller with an adaptive preview distance scheme for autonomous vehicles. Generally, the performance of a path-tracking controller depends on tire–road friction and is severely deteriorated on low-friction roads. To cope with the problem, it is necessary to design a path-tracking controller that is robust against variations in tire–road friction. In this paper, a preview function is introduced into the state-space model built for better path-tracking performance. With the preview function, an adaptive preview distance scheme is proposed to adaptively adjust the preview distance according to the variations in tire–road friction. Front-wheel steering (FWS) and four-wheel steering (4WS) are adopted as actuators for path tracking. With the state-space model, a linear quadratic regulator (LQR) is adopted as a controller design methodology. In the adaptive preview distance scheme, the best preview distance is obtained from simulation for several tire–road friction conditions. Curve fitting with an exponential function is applied to those preview distances with respect to the tire–road friction. To verify the performance of the adaptive preview distance scheme under variations in tire–road friction, a simulation is conducted on vehicle simulation software. From the simulation results, it was shown that the path-tracking controller with an adaptive preview distance scheme presented in this paper was effective for path tracking against variations in tire–road friction in the peak’s center offset, and the settling delays were reduced by 60% and 23%, respectively.
The Collocation Method Based on the New Chebyshev Cardinal Functions for Solving Fractional Delay Differential Equations
Authors: Jebreen Haifa Bin , Dassios Ioannis
Published: October 2024

The Chebyshev cardinal functions based on the Lobatto grid are introduced and used for the first time to solve the fractional delay differential equations. The presented algorithm is based on the collocation method, which is applied to solve the corresponding Volterra integral equation of the given equation. In the employed method, the derivative and fractional integral operators are expressed in the Chebyshev cardinal functions, which reduce the computational load. The method is characterized by its simplicity, adherence to boundary conditions, and high accuracy. An exact analysis has been provided to demonstrate the convergence of the scheme, and illustrative examples validate our investigation.
Grayscale Lithography and a Brief Introduction to Other Widely Used Lithographic Methods: A State-of-the-Art Review
Authors: Khonina Svetlana N. , Kazanskiy Nikolay L. , Butt Muhammad A.
Published: October 2024

Lithography serves as a fundamental process in the realms of microfabrication and nanotechnology, facilitating the transfer of intricate patterns onto a substrate, typically in the form of a wafer or a flat surface. Grayscale lithography (GSL) is highly valued in precision manufacturing and research endeavors because of its unique capacity to create intricate and customizable patterns with varying depths and intensities. Unlike traditional binary lithography, which produces discrete on/off features, GSL offers a spectrum of exposure levels. This enables the production of complex microstructures, diffractive optical elements, 3D micro-optics, and other nanoscale designs with smooth gradients and intricate surface profiles. GSL plays a crucial role in sectors such as microelectronics, micro-optics, MEMS/NEMS manufacturing, and photonics, where precise control over feature depth, shape, and intensity is critical for achieving advanced functionality. Its versatility and capacity to generate tailored structures make GSL an indispensable tool in various cutting-edge applications. This review will delve into several lithographic techniques, with a particular emphasis on masked and maskless GSL methods. As these technologies continue to evolve, the future of 3D micro- and nanostructure manufacturing will undoubtedly assume even greater significance in various applications.
How Trustworthy Are the Genomic Sequences of SARS-CoV-2 in GenBank?
Authors: Xia Xuhua
Published: October 2024

Well-annotated gene and genomic sequences serve as a foundation for making inferences in molecular biology and evolution and can directly impact public health. The first SARS-CoV-2 genome was submitted to the GenBank database hosted by the U.S. National Center for Biotechnology Information and used to develop the two successful vaccines. Conserved protein domains are often chosen as targets for developing antiviral medicines or vaccines. Mutation and substitution patterns provide crucial information not only on functional motifs and genome/protein interactions but also for characterizing phylogenetic relationships among viral strains. These patterns, together with the collection time of viral samples, serve as the basis for addressing the question of when and where the host-switching event occurred. Unfortunately, viral genomic sequences submitted to GenBank undergo little quality control, and critical information in the annotation is frequently changed without being recorded. Researchers often have no choice but to hold blind faith in the authenticity of the sequences. There have been reports of incorrect genome annotation but no report that casts doubt on the genomic sequences themselves because it seems theoretically impossible to identify genomic sequences that may not be authentic. This paper takes an innovative approach to show that some SARS-CoV-2 genomes submitted to GenBank cannot possibly be authentic. Specifically, some SARS-CoV-2 genomic sequences deposited in GenBank with collection times in 2023 and 2024, isolated from saliva, nasopharyngeal, sewage, and stool, are identical to the reference genome of SARS-CoV-2 (NC_045512). The probability of such occurrence is effectively 0. I also compile SARS-CoV-2 genomes with changed sample collection times. One may be led astray in bioinformatic analysis without being aware of errors in sequences and sequence annotation.
Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens
Authors: Pauciullo Silvia , Zulian Verdiana , La Frazia Simone , Paci Paola , Garbuglia Anna Rosa
Published: October 2024

Viral spillover represents the transmission of pathogen viruses from one species to another that can give rise to an outbreak. It is a critical concept that has gained increasing attention, particularly after the SARS-CoV-2 pandemic. However, the term is often used inaccurately to describe events that do not meet the true definition of spillover. This review aims to clarify the proper use of the term and provides a detailed analysis of the mechanisms driving zoonotic spillover, with a focus on the genetic and environmental factors that enable viruses to adapt to new hosts. Key topics include viral genetic variability in reservoir species, biological barriers to cross-species transmission, and the factors that influence viral adaptation and spread in novel hosts. The review also examines the role of evolutionary processes such as mutation and epistasis, alongside ecological conditions that facilitate the emergence of new pathogens. Ultimately, it underscores the need for more accurate predictive models and improved surveillance to better anticipate and mitigate future spillover events.
Detection by Real-Time PCR of Helicobacter pylori and Clarithromycin Resistance Compared to Histology on Gastric Biopsies
Authors: Pittie Guillaume , Laurent Terry , Radermacher Jean , Herens Sophie , Boeras Anca , Ho Giang
Published: October 2024

The global rise in Helicobacter pylori (H. pylori)-related gastric complications is largely driven by increasing antimicrobial resistance and treatment failures. As a result, accurate diagnosis followed by effective treatment is crucial. We analyzed 232 gastric biopsy samples from patients undergoing endoscopy during the method validation phase, followed by 502 samples in the routine evaluation phase. Each sample was tested using the Allplex™ H. pylori and ClariR Assay on a CFX96™ real-time PCR (RT-PCR) system, with results processed through Seegene Viewer software. In the validation phase, RT-PCR results were compared to bacterial culture, while in the routine phase, they were compared to histology. The sensitivity and specificity for H. pylori detection were 100% and 96.05% (95% Confidence Interval [CI]: 93.38–98.73), respectively. For clarithromycin resistance detection, the sensitivity and specificity were 100% and 93.33% (95% CI: 84.4–100). Additionally, RT-PCR identified 11 positive samples (10.89%) that histology failed to detect. Incorporating the Allplex™ H. pylori and ClariR Assay into our laboratory workflow improved efficiency, reduced turnaround time (TaT), and proved to be more sensitive than both culture and histology combined.
The Effects of Caffeine on Exercise in Hot Environments: A Bibliometric Study
Authors: Li Hansen , Yang Ying , Liu Qian , Liu Liming , Zhang Guodong , Zhang Xing , Yin Mingyue , Cao Yang
Published: October 2024

Background: Caffeine is widely recognized as an ergogenic aid to enhance athletic performance, yet its effects in hot environments remain relatively underexplored. Aims: To provide a comprehensive overview of the research landscape and identify research themes in this field. Methods: We systematically searched the Web of Science (WoS) and SCOPUS databases using keywords related to caffeine (e.g., caffe*), hot environments (e.g., heat, hot, or therm*), and athletic performance (e.g., cardio, endurance, or strength). The Bibliometrix package in R was used for bibliometric analysis and result visualization, while a narrative review was subsequently performed to identify research themes. Results: We found that studies examining the impact of caffeine on exercise in hot conditions are relatively sparse and have progressed slowly in recent years. Research in this domain has predominantly been concentrated within an academic network led by Professor Lawrence Armstrong. Recent contributions have been sporadically made by emerging scholars, with collaborations largely confined to a few research groups and countries. Key research themes identified include exercise performance, thermoregulation, fluid balance, physiological responses, immune responses, synergistic effects with other compounds, and the influence of individual differences. Of these, the first three themes—exercise performance, thermoregulation, and fluid balance—have received the most attention. Conclusions: Caffeine’s effects on exercise performance in hot environments have not been thoroughly studied. The existing research themes are varied, and the conclusions show considerable inconsistencies. Our study highlights the need for further research into the effects of caffeine dosage, administration methods, and population-specific variables. We also call for increased collaboration among research groups to advance scientific understanding and address the gaps in this field.
Adiponectin Signaling Modulates Fat Taste Responsiveness in Mice
Authors: Lin Fangjun , Masterson Emeline , Gilbertson Timothy A.
Published: October 2024

Background/Objectives: Adiponectin, the most abundant peptide hormone secreted by adipocytes, is a well-known homeostatic factor regulating lipid metabolism and insulin sensitivity. It has been shown that the adiponectin receptor agonist AdipoRon selectively enhances cellular responses to fatty acids in human taste cells, and adiponectin selectively increases taste behavioral responses to intralipid in mice. However, the molecular mechanism underlying the physiological effects of adiponectin on fat taste in mice remains unclear. Conclusions: Here we define AdipoR1 as the mediator responsible for the enhancement role of adiponectin/AdipoRon on fatty acid-induced responses in mouse taste bud cells. Methods and Results: Calcium imaging data demonstrate that AdipoRon enhances linoleic acid-induced calcium responses in a dose-dependent fashion in mouse taste cells isolated from circumvallate and fungiform papillae. Similar to human taste cells, the enhancement role of AdipoRon on fatty acid-induced responses was impaired by co-administration of an AMPK inhibitor (Compound C) or a CD36 inhibitor (SSO). Utilizing Adipor1-deficient animals, we determined that the enhancement role of AdipoRon/adiponectin is dependent on AdipoR1, since AdipoRon/adiponectin failed to increase fatty acid-induced calcium responses in taste bud cells isolated from these mice. Brief-access taste tests were performed to determine whether AdipoRon’s enhancement role was correlated with any differences in taste behavioral responses to fat. Although AdipoRon enhances the cellular responses of taste bud cells to fatty acids, it does not appear to alter fat taste behavior in mice. However, fat-naïve Adipor1−/− animals were indifferent to increasing concentrations of intralipid, suggesting that adiponectin signaling may have profound effects on the ability of mice to detect fatty acids in the absence of previous exposure to fatty acids and fat-containing diets.
The Impact of Bioactive Molecules from Probiotics on Child Health: A Comprehensive Review
Authors: Guamán Linda P. , Carrera-Pacheco Saskya E. , Zúñiga-Miranda Johana , Teran Enrique , Erazo Cesar , Barba-Ostria Carlos
Published: October 2024

Background: This review investigates the impact of bioactive molecules produced by probiotics on child health, focusing on their roles in modulating gut microbiota, enhancing immune function, and supporting overall development. Key metabolites, including short-chain fatty acids (SCFAs), bacteriocins, exopolysaccharides (EPSs), vitamins, and gamma-aminobutyric acid (GABA), are highlighted for their ability to maintain gut health, regulate inflammation, and support neurodevelopment. Objectives: The aim of this review is to examine the mechanisms of action and clinical evidence supporting the use of probiotics and postbiotics in pediatric healthcare, with a focus on promoting optimal growth, development, and overall health in children. Methods: The review synthesizes findings from clinical studies that investigate the effects of probiotics and their metabolites on pediatric health. The focus is on specific probiotics and their ability to influence gut health, immune responses, and developmental outcomes. Results: Clinical studies demonstrate that specific probiotics and their metabolites can reduce gastrointestinal disorders, enhance immune responses, and decrease the incidence of allergies and respiratory infections in pediatric populations. Additionally, postbiotics—bioactive compounds from probiotic fermentation—offer promising benefits, such as improved gut barrier function, reduced inflammation, and enhanced nutrient absorption, while presenting fewer safety concerns compared to live probiotics. Conclusions: By examining the mechanisms of action and clinical evidence, this review underscores the potential of integrating probiotics and postbiotics into pediatric healthcare strategies to promote optimal growth, development, and overall health in children.
Concurrent Direct Inter-ONU and Upstream Communications in IMDD PONs Incorporating P2MP Flexible Optical Transceivers and Advanced Passive Remote Nodes
Authors: Jin Wei , Chen Lin , He Jiaxiang , Giddings Roger Philip , Huang Yi , Hao Ming , Faruk Md. Saifuddin , Yi Xingwen , Wang Tingyun , Tang Jianming
Published: October 2024

Driven by a large number of emerging diversified services, in the 5G and beyond era, concurrent direct inter-ONU and upstream communications inside a PON-based mobile access network are highly desirable to provide dynamic, ultra-dense, and fast ONU-to-ONU (without involving an OLT) and ONU-to-OLT connections. To cost-effectively deliver highly dynamic and low latency direct inter-ONU communications, this paper proposes and experimentally demonstrates novel concurrent direct inter-ONU and upstream communications in an upstream 27 km, >62.47 Gbit/s IMDD PON. For supporting inter-ONU communications between a large number of ONUs, an advanced passive remote node is also proposed. Based on different passive optical components, this remote node can be implemented using two approaches, which can, respectively, reduce the inter-ONU signal power losses by >12.2 dB and >16.6 dB (for 128 ONUs) in comparison with existing inter-ONU communication techniques’ remote nodes. In each ONU and OLT, a single pair of cascaded IFFT/FFT-based point-to-multipoint (P2MP) flexible optical transceivers are employed to simultaneously and dynamically establish multiple ONU-to-ONU and ONU-to-OLT communications according to actual users’ requirements. Experimental results show that the proposed network has excellent robustness against various transmission system impairments, including chromatic dispersion, the Rayleigh and Brillouin backscattering effects, and the channel interference effects. For each ONU, dynamic channel allocation can be made without compromising its overall performance.
Calculation of Tool Offset and Tool Radius Errors Based on On-Machine Measurement and Least Squares Method in Ultra-Precision Diamond Turning
Authors: Peng Yao , Ding Han , Zhang Dong , Luo Miao
Published: October 2024

Metal mirrors will be widely used in the coming decades. Therefore, as one of the enabling technologies for metal optical freeform surface manufacturing, ultra-precision (UP) diamond turning error compensation has become a research hotspot. However, for the tool offset error and tool radius error, which are the main errors in UP diamond turning, no precise and efficient calculation method has been found in the literature. In this study, a more precise and efficient algorithm was developed and validated in three ways using on-machine measurement data and profilometer measurement data. After one compensation, the tool offset error can be reduced to below 0.1 μm, and the tool radius error can be reduced to below 1 micrometer, which will significantly improve the UP turning accuracy and efficiency of optical parts.
Hydrogen Bond Donors in the Catalytic Pocket: The Case of the Ring-Opening Polymerization of Cyclic Esters Catalyzed by an Amino-Propoxide Aluminum Complex
Authors: Impemba Salvatore , Viceconte Antonella , Tozio Irene , Anwar Shoaib , Manca Gabriele , Milione Stefano
Published: October 2024

A new aluminum complex (NSO)AlMe2 featuring a hydrogen bond donor on the ligand backbone has been synthesized via the reaction of AlMe3 with 1-((2-(isopropylamino)phenyl)thio)propan-2-ol (NSO-H) and spectroscopically characterized. In the complex, the aluminum atom is in a distorted tetrahedral coordination sphere determined by the anionic oxygen and neutral nitrogen atoms of the ligand and by the two carbon atoms of the alkyl groups. After proper activation, the complex (NSO)AlMe2 was able to promote the ring-opening polymerization of L-, rac-lactide, ε-caprolactone and rac-β-butyrolactone. The polymerization of rac-lactide was faster than that of L-lactide: in a toluene solution at 80 °C, the high monomer conversion of 100 equivalents was achieved in 1.5 h, reaching a turnover frequency of 63 molLA·molAl–1·h–1. The experimental molecular weights of the obtained polymers were close to those calculated, assuming the growth of one polymer chain for one added alcohol equivalent and the polydispersity indexes were monomodal and narrow. The kinetic investigation of the polymerization led to the determination of the apparent propagation constants and the Gibbs free energies of activation for the reaction; the terminal groups of the polymers were also identified. The complex (NSO)AlMe2 was active in harsh conditions such as at a very low concentration or in the melt using technical-grade rac-lactide. A relatively high level of activity was observed in the ring-opening polymerization of ε-caprolactone and rac-β-butyrolactone. DFT calculations were performed and revealed the central role of the NH function of the coordinated ligand. Acting as a hydrogen bond donor, it docks the monomer in the proximity of the metal center and activates it toward the nucleophilic attack of the growing polymer chain.
The Impact of Chlorinated Water and Sun Exposure on the Durability and Performance of Swimwear Materials
Authors: Potočić Matković Vesna Marija , Salopek Čubrić Ivana , Krstović Katarina
Published: October 2024

Understanding the factors that affect how materials age is essential for creating a durable product with long-lasting properties. It is also important to prioritize defining aging parameters that reflect the real-world conditions the materials will encounter. For this study, a range of swimwear materials were selected consisting of a blend of polymer (polyamide/polyester) and elastane in varying ratios. In order to simulate aging conditions, materials were immersed in chlorinated outdoor pool water during the summer season, either in shade or the sun, for 200 and 300 h. The materials were tested for mass per unit area, thickness, tensile properties, and moisture management. A slight mass per unit area increase was observed, rising from 1.0% after 200 h of chlorine and sunlight exposure to 3.7% after 300 h. Thickness increased by 1.7% after 200 h and 3.2% after 300 h of chlorine exposure, with no significant effect of sunlight. Breaking force dropped by 12.4% after 200 h in chlorine and 8.2% in chlorine and sunlight, becoming more pronounced after 300 h (65.7% in chlorine and 65.1% in chlorine and sunlight). The overall moisture management capability declined from 0.4888 to 0.3457 after 200 h in chlorine and 0.3393 with sunlight, dropping further after 300 h to 0.3838 and 0.3253, respectively.
Characterization of Mixtures Based on High-Density Polyethylene and Plasticized Starch
Authors: Stelescu Maria Daniela , Oprea Ovidiu-Cristian , Constantinescu Doina , Motelica Ludmila , Ficai Anton , Trusca Roxana-Doina , Sonmez Maria , Gurau Dana Florentina , Georgescu Mihai , Constantinescu Rodica Roxana , Vasile Bogdan-Stefan , Ficai Denisa
Published: October 2024

This paper presents the obtaining and characterization of blends based on high-density polyethylene (HDPE) and plasticized starch. In addition to plasticized starch (28.8% w/w), the compositions made also contained other ingredients, such as polyethylene-graft-maleic anhydride as a compatibilizer, ethylene propylene terpolymer elastomer, cross-linking agents, and nanoclay. Plasticized starch contains 68.6% w/w potato starch, 29.4% w/w glycerin, and 2% w/w anhydrous citric acid. Blends based on HDPE and plasticized starch were made in a Brabender Plasti-Corder internal mixer at 160 °C, and plates for testing were obtained using the compression method. Thermal analyses indicate an increase in the crystallization degree of the HDPE after the addition of plasticized starch. SEM micrographs indicate that blends are compatibilized, with the plasticized starch being well dispersed as droplets in the HDPE matrix. Samples show high hardness values (62–65° ShD), good tensile strength values (14.88–17.02 N/mm2), and Charpy impact strength values (1.08–2.27 kJ/m2 on notched samples, and 7.96–20.29 kJ/m2 on unnotched samples). After 72 h of water immersion at room temperature, mixtures containing a compatibilizer had a mass variation below 1% and water absorption values below 1.7%. Upon increasing the water immersion temperature to 80 °C, the sample without the compatibilizer showed a mass reduction of −2.23%, indicating the dissolution of the plasticized starch in the water. The samples containing the compatibilizer had a mass variation of max 8.33% and a water absorption of max 5.02%. After toluene immersion for 72 h at room temperature, mass variation was below 8%.
Examination of the Anti-Biofilm Properties of Lignocellulose-Based Activated Carbon from Black Alder for Water Treatment Applications
Authors: Kandić Irina , Kragović Milan , Gulicovski Jelena , Cvetković Stefana , Marinković Ana , Stanković Slaviša , Stojmenović Marija
Published: October 2024

Nowadays, there is increasing global demand for activated carbon considering its wide usage as an adsorbent of environmental pollutants. Biowaste rich in lignocellulose, like the cone-like flowers of black alder (A_AC), shows promise as a precursor for novel materials. Building upon previous research and this material’s established applicability for removing cyanobacteria cells and cyanotoxins from water, this study investigates the CNOHS composition of A_AC and its potential to inhibit biofilm formation. A comprehensive CNOHS analysis showed the material composition as 64.5%, 1.77%, 28.83%, 2.05%, and 0.12% for C, N, O, H, and S respectively. The material’s efficacy in inhibiting biofilm formation across eight selected bacterial strains was evaluated. The results showed biofilm formation rates of 62.6%, 22.1%, 73.8%, 12.1%, 40.9%, 24.2%, 9.2%, and 7.6% for Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Salmonella Typhimurium, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, and Enterococcus faecalis, respectively. Biofilm formation is influenced by biotic and abiotic factors, especially the physicochemical properties of the substrate. This study offers insights into the potential of black-alder-derived activated carbon to prevent biofilm formation, highlighting its role in water purification and environmental protection.
Industrial Co-Agglomeration and Urban Green Total Factor Productivity: Multidimensional Mechanism and Spatial Effect
Authors: Xu Hongxia , Xu Ning
Published: October 2024

The impact of industrial co-agglomeration (ICA) on green total factor productivity (GTFP) has garnered considerable academic attention. However, there remains a gap in research systematically investigating how ICA affects China’s GTFP within the framework of green development, specifically by analyzing transmission mechanisms, regulatory mechanisms, and spatial spillover effects. To address this gap, this study utilizes panel data from 283 Chinese cities, spanning the years 2006 to 2020, and conducts both theoretical and empirical analyses to examine ICA’s influence on GTFP through these three mechanisms. Our findings indicate that ICA significantly enhances GTFP by alleviating the mismatch of capital and energy factors but does not improve GTFP by addressing labor mismatches. Furthermore, when the intensity of local government competition exceeds a threshold of 14.3825, the positive impact of ICA diminishes, whereas an environmental regulation intensity above 0.4381 strengthens ICA’s positive effect on GTFP. ICA was found to substantially increase local GTFP and generate positive spatial spillover effects on surrounding cities within a 100 km radius. Co-agglomeration of both high-end and low-end producer services with manufacturing boosts local GTFP, while co-agglomeration of low-end producer services with manufacturing also enhances GTFP in adjacent cities. In megacities, ICA positively influences both local and nearby GTFP, whereas in large cities, ICA tends to suppress GTFP in neighboring areas. Additionally, with the exception of the Middle Yangtze River and Pearl River Delta city clusters, ICA in urban clusters enhances local GTFP; ICA in the Middle Yangtze River cluster promotes GTFP in neighboring areas, whereas ICA in the Chengdu–Chongqing cluster inhibits neighboring GTFP.
Borel Summation Can Be Controlled by Critical Indices
Authors: Gluzman Simon
Published: October 2024

We consider application of the self-similarity principle in approximation theory under the conditions of asymptotic scale-invariance. For the effective summation of the asymptotic series methods, an iterative Borel summation with self-similar iterated roots is applied. The approximants follow from the self-similarity considerations and behave asymptotically as a power-law satisfying the asymptotic scale invariance. Optimal conditions on convergence of the sequence of approximants are imposed through the critical indices defined from the approximants. The indices are understood as control parameters for the optimal convergence of the asymptotic series. Such interpretation of the indices leads to an overall improvement of accuracy in calculations of the indices. The statement is supported by fifteen examples from condensed matter physics, quantum mechanics and field theory.
Ultra-Low Frequency Waves of Foreshock Origin Upstream and Inside of the Magnetospheres of Earth, Mercury, and Saturn Related to Solar Wind–Magnetosphere Coupling
Authors: Bebesi Zsofia , Dwivedi Navin Kumar , Kis Arpad , Juhász Antal , Heilig Balazs
Published: October 2024

This review examines ultra-low frequency (ULF) waves across different planetary environments, focusing on Earth, Mercury, and Saturn. Data from spacecraft missions (CHAMP, Swarm, and Oersted for Earth; MESSENGER for Mercury; and Cassini for Saturn) provide insights into ULF wave dynamics. At Earth, compressional ULF waves, particularly Pc3 waves, show significant power near the equator and peak around Magnetic Local Time (MLT) = 11. These waves interact complexly with Alfvén waves, impacting ionospheric responses and geomagnetic field line resonances. At Mercury, ULF waves transition from circular to linear polarization, indicating resonant interactions influenced by compressional components. MESSENGER data reveal a lower occurrence rate of ULF waves in Mercury’s foreshock compared to Earth’s, attributed to reduced backstreaming protons and lower solar wind Alfvénic Mach numbers, as ULF wave activity increases with heliocentric distance. Short Large-Amplitude Magnetic Structures (SLAMS) observed at Mercury and Saturn show distinct characteristics compared to those of Earth, including the presence of whistler precursos waves. However, due to the large differences in heliospheric distances, SLAMS (their temporal scale size correlate with the ULF wave frequency) at Mercury are significantly shorter in duration than at Earth or Saturn, since the ULF wave frequency primarily depends on the strength of the interplanetary magnetic field. This review highlights the variability of ULF waves and SLAMS across planetary environments, emphasizing Earth’s well-understood ionospheric interactions and the unique behaviours observed for Mercury and Saturn. These findings enhance our understanding of space plasma dynamics and underline the need for further research regarding planetary magnetospheres.
Generalized Schwarzschild Spacetimes with a Linear Term and a Cosmological Constant
Authors: Lecian Orchidea Maria
Published: October 2024

Particular Kottler spacetimes are analytically investigated. The investigated spacetimes are spherically symmetric nonrotating spacetimes endowed with a Schwarzschild solid-angle element. SchwarzschildNairiai spacetimes, Schwarzschild spacetimes with a linear term, and Schwarzschild spacetimes with a linear term and a cosmological constant are studied. The infinite-redshift surfaces are analytically written. To this aim, the parameter spaces of the models are analytically investigated, and the conditions for which the analytical radii are reconducted to the physical horizons are used to set and to constrain the parameter spaces. The coordinate-singularity-avoiding coordinate extensions are newly written. Schwarzschild spacetimes with a linear term and a cosmological constant termare analytically studied, and the new singularity-avoiding coordinate extensions are detailed. The new roles of the linear term and of the cosmological constant term in characterizing the Schwarzschild radius are traced. The generalized Schwarzschild–deSitter case and generalized Schwarzschild–anti-deSitter case are characterized in a different manner. The weak field limit is newly recalled. The embeddings are newly provided. The quantum implementation is newly envisaged. The geometrical objects are newly calculated. As a result, for the Einstein field equations, the presence of quintessence is newly excluded. The Birkhoff theorem is newly proven to be obeyed.
Comparative Analysis of Host Cell Entry Efficiency and Neutralization Sensitivity of Emerging SARS-CoV-2 Lineages KP.2, KP.2.3, KP.3, and LB.1
Authors: Chen Nianzhen , Decker Katharina Emma , Schulz Sebastian R. , Kempf Amy , Nehlmeier Inga , Moldenhauer Anna-Sophie , Dopfer-Jablonka Alexandra , Behrens Georg M. N. , Stankov Metodi V. , Manthey Luis , Jäck Hans-Martin , Hoffmann Markus , Pöhlmann Stefan , Arora Prerna
Published: October 2024

New SARS-CoV-2 lineages continue to evolve and may exhibit new characteristics regarding host cell entry efficiency and potential for antibody evasion. Here, employing pseudotyped particles, we compared the host cell entry efficiency, ACE2 receptor usage, and sensitivity to antibody-mediated neutralization of four emerging SARS-CoV-2 lineages, KP.2, KP.2.3, KP.3, and LB.1. The XBB.1.5 and JN.1 lineages served as controls. Our findings reveal that KP.2, KP.2.3, KP.3, and LB.1 lineages enter host cells efficiently and in an ACE2-dependent manner, and that KP.3 is more adept at entering Calu-3 lung cells than JN.1. However, the variants differed in their capacity to employ ACE2 orthologues from animal species for entry, suggesting differences in ACE2 interactions. Moreover, we demonstrate that only two out of seven therapeutic monoclonal antibody (mAbs) in preclinical development retain robust neutralizing activity against the emerging JN.1 sublineages tested, while three mAbs displayed strongly reduced neutralizing activity and two mAbs lacked neutralizing activity against any of the lineages tested. Furthermore, our results show that KP.2, KP.2.3, KP.3, and LB.1 lineages evade neutralization by antibodies induced by infection or vaccination with greater efficiency than JN.1, particularly in individuals without hybrid immunity. This study indicates that KP.2, KP.2.3, KP.3, and LB.1 differ in ACE2 interactions and the efficiency of lung cell entry and suggest that evasion of neutralizing antibodies drove the emergence of these variants.
Assessment of Flood Disaster Risk in the Lancang–Mekong Region
Authors: Sun Qingquan , Song Wei , Han Ze , Song Wen , Wang Zhanyun
Published: October 2024

The Lancang–Mekong Region encompasses six countries, covering an area exceeding five million square kilometers and containing a population of more than 400 million. Floods in this region may cause extremely serious losses of lives and property. However, due to the severe shortage of flood disaster data, loss data and meteorological monitoring data, the assessment of flood disaster risks in this region remains highly formidable. In view of this, we systematically integrated the flood disaster data from EM-DAT (the Emergency Events Database), Desinventar (a disaster information management system), Reliefweb (a humanitarian information service provided by the United Nations Office for the Coordination of Humanitarian Affairs), and ADRC (the Asian Disaster Reduction Center), coupled with GLDAS (Global Land Data Assimilation System) precipitation data and the population and economic data from the World Bank, and comprehensively considered vulnerability, exposure, and loss criteria to assess the flood disaster risks in the Lancang–Mekong Region. The research findings are as follows: (1) From 1965 to 2017, a total of 370 floods occurred in the Lancang–Mekong Region, among which the proportion of floods in Vietnam and Thailand combined was as high as 43.7%. In contrast, the number of floods in Qinghai and Tibet in China was relatively small, with a combined proportion of only 1.89%. (2) When mild flood disasters occur, the southern part of Myanmar, the western part of Thailand, and the northeastern part of Vietnam are faced with relatively large loss threats; when moderate flood disasters occur, the central part of Myanmar, the eastern part of Cambodia, and the southern part of Vietnam are faced with comparatively large loss threats; when severe flood disasters occur, high-loss areas are mainly concentrated in the southern part of Vietnam. (3) Considering exposure, vulnerability, and hazards comprehensively, the high-risk areas of floods in the Lancang–Mekong Region are mainly distributed in the central–southern part of Myanmar, the northeastern part of Vietnam, and the southern part of the area bordering Cambodia and Vietnam; the medium-risk areas are mainly distributed in the central part of Thailand and the eastern part of Sichuan in China; relatively speaking, other areas in the Lancang–Mekong Region have a lower flood risk level. This research can provide references for flood risk assessment in regions with scarce data and technical support for flood disaster prevention and control as well as risk management in the Lancang–Mekong Region.
PENGARUH PENERAPAN STANDAR OPERASIONAL PROSEDUR DAN DISIPLIN KERJA TERHADAP KINERJA: KEPUASAN KERJA SEBAGAI VARIABEL MEDIASI
Authors: Amelia Cindy Cahya Adisty  , M. Farid Wajdi
Published: October 2024

This study aims to analyze the influence of Standard Operating Procedures (SOP) implementation and work discipline on employee performance with job satisfaction as a mediating variable at PT. Paragon Technology and Innovation. The research employs a quantitative approach with purposive sampling technique. Data were collected through questionnaires distributed to 85 employees. Data analysis uses Structural Equation Modeling (SEM) with SmartPLS. The results show that: (1) SOP has a negative insignificant effect on employee performance, (2) Work discipline has a significant positive effect on employee performance, (3) SOP has a significant positive effect on job satisfaction, (4) Work discipline has a significant positive effect on job satisfaction, (5) Job satisfaction has a significant positive effect on employee performance, (6) Job satisfaction cannot mediate the relationship between SOP and employee performance, and (7) Job satisfaction can mediate the relationship between work discipline and employee performance.
Combining Chemotherapy Agents and Autophagy Modulators for Enhanced Breast Cancer Cell Death
Authors: Nikbakht Mohsen , Moomivand Soraya , Babaei Shadi , haghi Atousa , Sharifianjazi Fariborz , Majd Ahmad , Bikhof Torbati Maryam , Mousavi Seyed Asadoullah
Published: October 2024

Purpose: Autophagy, governed by genes with dual roles in cell death and survival, plays a crucial role in cancer persistence. Arsenic trioxide (ATO), carboplatin (CP), and cyclophosphamide (CY) are used to treat various cancers. ATO impedes cell proliferation and triggers apoptosis in cancer cells. CP, a platinum-based drug, damages cancer cell DNA, while CY acts as an alkylating agent, disrupting cell proliferation. This study investigates the combined effects of ATO, CP, and CY on inducing apoptosis and modulating autophagy in triple-negative breast cancer (TNBC) cell lines, BT-20 and MDA-MB-231. Methods: The cytotoxic effects of ATO, CP, and CY, alone and in combination, were evaluated using the MTT assay on BT-20 and MDA-MB-231 cells. Apoptosis and cell cycle progression were analyzed by annexin-V FITC/PI staining and flow cytometry. Gene expression of autophagy- and apoptosis-related markers, including Beclin 1, LC3, caspase 3, and BCL2, was quantified using RT-PCR. Data were analyzed using GraphPad Prism 4.0 with one-way ANOVA followed by Dunnett's test. Results: The The combination of ATO, CP, and CY significantly reduced cell viability and enhanced apoptosis, evidenced by increased caspase-3 activity and reduced BCL2 expression. Cell cycle arrest in the G1 phase was observed, alongside elevated autophagy markers Beclin 1 and LC3. Conclusion: The combination of ATO, CP, and CY induces synergistic effects in promoting apoptosis and autophagy in TNBC cell lines. These findings suggest that this combination therapy could be a promising approach to enhancing treatment efficacy in aggressive breast cancers, offering new insights into potential therapeutic strategies.