bluuebunny/crossref_metadata_2025 huggingface dataset:
Artilharia Ligeira:
Authors: Moraes Everton de Oliveira
Published: June 2023

O objetivo deste artigo é analisar como foi possível que a publicidade, hoje vista como indissociável do status quo capitalista, pode ser enxergada por artistas como Paulo Leminski e Luiz Rettamozo, como lugar passível de ser ocupado pela figura do artista, não apenas como fonte de renda, mas também como tática de guerrilha artística, modo de difusão e diluição de mensagens com alto teor de linguagem inovadora. Mesmo produzindo uma arte que se pretendia altamente sofisticada e inventiva, Leminski e Rettamozo que, também participam intensamente do publicitário curitibano entre o final da década de 1970 e o final dos anos 1980. Interessa, sobretudo, compreender o modo como buscaram articular uma argumentação que fundamentava esta atuação como estratégia legítima de intervenção artística no mercado e na comunicação de massas.
Common cold
Authors: Eccles Ronald
Published: June 2023

The common cold is a unique human disease, as it is arguably the most common disease and because of the large number of respiratory viruses causing colds it is one of the most complex of human diseases. This review discusses the respiratory viruses and notes that all these viruses may cause the illness complex recognised as the common cold. The common cold is discussed as part of the “iceberg concept” of disease which ranges from asymptomatic infection to severe illness and death. The factors influencing the incidence of colds are discussed: crowding and sociability, stress, smoking and alcohol, immune status, sex, age, sleep, season, chilling, nutrition and exercise. The mechanism of symptoms related to the innate immune response is explained and symptomatic treatments are tabulated. Morbidity associated with common cold is discussed and possible vaccines.
Biomechanical effects of the medial meniscus horizontal tear and the resection strategy on the rabbit knee joint under resting state: finite element analysis
Authors: Xue Anqi , Mao Zuming , Zhu Xiaoyu , Yang Qiang , Wang Peichen , Mao Zimu , Du Mingze , Ma Xu , Jiang Dong , Fan Yubo , Zhao Feng
Published: June 2023

The biomechanical changes following meniscal tears and surgery could lead to or accelerate the occurrence of osteoarthritis. The aim of this study was to investigate the biomechanical effects of horizontal meniscal tears and different resection strategies on a rabbit knee joint by finite element analysis and to provide reference for animal experiments and clinical research. Magnetic resonance images of a male rabbit knee joint were used to establish a finite element model with intact menisci under resting state. A medial meniscal horizontal tear was set involving 2/3 width of a meniscus. Seven models were finally established, including intact medial meniscus (IMM), horizontal tear of the medial meniscus (HTMM), superior leaf partial meniscectomy (SLPM), inferior leaf partial meniscectomy (ILPM), double-leaf partial meniscectomy (DLPM), subtotal meniscectomy (STM), and total meniscectomy (TTM). The axial load transmitted from femoral cartilage to menisci and tibial cartilage, the maximum von Mises stress and the maximum contact pressure on the menisci and cartilages, the contact area between cartilage to menisci and cartilage to cartilage, and absolute value of the meniscal displacement were analyzed and evaluated. The results showed that the HTMM had little effect on the medial tibial cartilage. After the HTMM, the axial load, maximum von Mises stress and maximum contact pressure on the medial tibial cartilage increased 1.6%, 1.2%, and 1.4%, compared with the IMM. Among different meniscectomy strategies, the axial load and the maximum von Mises stress on the medial menisci varied greatly. After the HTMM, SLPM, ILPM, DLPM, and STM, the axial load on medial menisci decreased 11.4%, 42.2%, 35.4% 48.7%, and 97.0%, respectively; the maximum von Mises stress on medial menisci increased 53.9%, 62.6%, 156.5%, and 65.5%, respectively, and the STM decreased 57.8%, compared to IMM. The radial displacement of the middle body of the medial meniscal was larger than any other part in all the models. The HTMM led to few biomechanical changes in the rabbit knee joint. The SLPM showed minimal effect on joint stress among all resection strategies. It is recommended to preserve the posterior root and the remaining peripheral edge of the meniscus during surgery for an HTMM.
Posterior concentration of Wolbachia during the early embryogenesis of the host dynamically shapes the tissue tropism of Wolbachia in host Trichogramma wasps
Authors: Zhou Jin-Cheng , Dong Qian-Jin , Shang Dan , Ning Su-Fang , Zhang Huan-Huan , Wang Ying , Che Wu-Nan , Dong Hui , Zhang Li-Sheng
Published: June 2023

Introduction

The bacterial endosymbiont, Wolbachia spp. induce thelytokous parthenogenesis in certain parasitoid wasps, such as the egg parasitoid wasps Trichogramma spp. To complete the cycle of vertical transmission, Wolbachia displays efficient transovarial transmission by targeting the reproductive tissues and often exhibits strong tissue-specific tropism in their host.

Method

The present study aimed to describe the basic Wolbachia distribution patterns that occur during the development of Wolbachia-infected, thelytokous Trichogramma dendrolimi, and T. pretiosum. We used fluorescence in situ hybridization (FISH) to investigate Wolbachia signal dynamics during early embryogenesis (from 30 to 120 min). Wolbachia titers and distributions from the embryo to adult stages of Trichogramma after early embryogenesis were detected by absolute quantitative polymerase chain reaction (AQ-PCR) and FISH. The symmetry ratios (SR) of the Wolbachia signals were calculated using the SR odds ratios in the anterior and posterior parts of the host. The SR was determined to describe Wolbachia tropism during early embryogenesis and various developmental stages of Trichogramma.

Results

Wolbachia was concentrated in the posterior part of the embryo during early embryogenesis and the various developmental stages of both T. dendrolimi and T. pretiosum. Wolbachia density increased with the number of nuclei and the initial mitotic division frequency during early embryogenesis. The total Wolbachia titer increased with postembryogenesis development in both T. dendrolimi and T. pretiosum. However, the Wolbachia densities relative to body size were significantly lower at the adult and pupal stages than they were at the embryonic stage.

Discussion

The present work revealed that posterior Wolbachia concentration during early host embryogenesis determined Wolbachia localization in adult wasps. By this mechanism, Wolbachia exhibits efficient vertical transmission across generations by depositing only female Wolbachia-infected offspring. The results of this study describe the dynamics of Wolbachia during the development of their Trichogramma host. The findings of this investigation helped clarify Wolbachia tropism in Trichogramma wasps.
Successful cardiopulmonary resuscitation of cardiac arrest induced by massive pulmonary embolism under general anesthesia: a case report
Authors: Li Zhen , Cai Ning
Published: June 2023

Background

While pulmonary embolism (PE) is a common occurrence, a large life-threatening PE is not. Herein, we discuss the case of a patient with a life-threatening PE that occurred under general anesthesia.

Case presentation

We present the case of a 59-year-old male patient who was at bed rest for several days due to trauma, which resulted in femoral and rib fractures and a lung contusion. The patient was scheduled for femoral fracture reduction and internal fixation under general anesthesia. After disinfection and surgical towel laying, there was a sudden occurrence of severe PE and cardiac arrest; the patient was successfully resuscitated. Computed tomography pulmonary angiography (CTPA) was performed to confirm the diagnosis, and the patient’s condition improved after thrombolytic therapy. Unfortunately, the patient’s family eventually discontinued treatment.

Discussion

Massive PE frequently occurs suddenly, may endanger a patient’s life at any point in time, and cannot be diagnosed quickly on the basis of clinical manifestations. Although the vital signs fluctuate greatly and there is insufficient time to conduct more tests, some factors such as special disease history, electrocardiography, end-tidal carbon dioxide, and blood gas analysis may help us determine the preliminary diagnosis; however, the final diagnosis is made using CTPA. Current treatment options include thrombectomy, thrombolysis, and early anticoagulation, of which thrombolysis and early anticoagulation are the most feasible.

Conclusion

Massive PE is a life-threatening disease that requires early diagnosis and timely treatment to save patients’ lives.
Life's Essential 8 and carotid artery plaques: the Swedish cardiopulmonary bioimage study
Authors: Herraiz-Adillo Ángel , Ahlqvist Viktor H. , Higueras-Fresnillo Sara , Berglind Daniel , Wennberg Patrik , Lenander Cecilia , Daka Bledar , Ekstedt Mattias , Sundström Johan , Ortega Francisco B. , Östgren Carl Johan , Rådholm Karin , Henriksson Pontus
Published: June 2023

Background

To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques.

Methods

Randomly recruited participants aged 50–64 years from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were analysed. According to the AHA definitions, two CVH scores were calculated: i) the LE8 score (0, worst CVH; 100, best CVH) and two different versions of the LS7 score [(0–7) and (0–14), 0 indicating the worst CVH]. Ultrasound-diagnosed carotid plaques were classified as no plaque, unilateral, and bilateral plaques. Associations were studied by adjusted multinomial logistic regression models and adjusted (marginal) prevalences, while comparison between LE8 and LS7 scores was performed through receiver operating characteristic (ROC) curves.

Results

After exclusions, 28,870 participants remained for analysis (50.3% women). The odds for bilateral carotid plaques were almost five times higher in the lowest LE8 (<50 points) group [OR: 4.93, (95% CI: 4.19–5.79); adjusted prevalence 40.5%, (95% CI: 37.9–43.2)] compared to the highest LE8 (≥80 points) group [adjusted prevalence 17.2%, (95% CI: 16.2–18.1)]. Also, the odds for unilateral carotid plaques were more than two times higher in the lowest LE8 group [OR: 2.14, (95% CI: 1.82–2.51); adjusted prevalence 31.5%, (95% CI: 28.9–34.2)] compared to the highest LE8 group [adjusted prevalence 29.4%, (95% CI: 28.3–30.5)]. The areas under ROC curves were similar between LE8 and LS7 (0–14) scores: for bilateral carotid plaques, 0.622 (95% CI: 0.614–0.630) vs. 0.621 (95% CI: 0.613–0.628), P = 0.578, respectively; and for any carotid plaque, 0.602 (95% CI: 0.596–0.609) vs. 0.600 (95% CI: 0.593–0.607), P = 0.194, respectively.

Conclusion

The new LE8 score showed inverse and dose-response associations with carotid plaques, particularly bilateral plaques. The LE8 did not outperform the conventional LS7 score, which showed similar ability to predict carotid plaques, especially when scored as 0–14 points. We conclude that both the LE8 and LS7 may be useful in clinical practice for monitoring CVH status in the adult population.
Photoplethysmography-documented atrial fibrillation in the first week after catheter ablation is associated with lower success rates
Authors: Manninger Martin , Hermans Astrid N. L. , Caracioni Andrei-Antonio , Rohrer Ursula , Eberl Anna-Sophie , Vernooy Kevin , Zirlik Andreas , Linz Dominik , Scherr Daniel
Published: June 2023

Aims

To test the feasibility of postprocedural photoplethysmography (PPG) rhythm telemonitoring during the first week after atrial fibrillation (AF) ablation and its predictive value for later AF recurrence.

Methods

PPG rhythm telemonitoring during the first week after the ablation procedure was offered to a total of 382 consecutive patients undergoing AF ablation. Patients were instructed to perform 1 min PPG recordings by a mobile health application 3 times per day and in case of symptoms. Clinicians assessed the PPG tracings via a secured cloud and the information was remotely integrated into the therapeutic pathway via teleconsultation (TeleCheck-AF approach).

Results

119 patients (31%) agreed to perform PPG rhythm telemonitoring after ablation. Patients included in the TeleCheck-AF approach were younger compared to those who declined participation (58 ± 10 vs. 62 ± 10 years, p < 0.001). Median follow up duration was 544 (53–883) days. 27% of patients had PPG tracings suggestive of AF in the week following the ablation. In 24% of patients, the integration of PPG rhythm telemonitoring resulted in a remote clinical intervention during teleconsultation. During follow-up of one year, 33% of patients had ECG-documented AF recurrences. PPG recordings suggestive of AF in the week after ablation were predictive of late recurrences (p < 0.001).

Conclusion

PPG rhythm telemonitoring during the first week after AF ablation often triggered clinical interventions. Due to its high availability, PPG-based follow-up actively involving patients after AF ablation may close a diagnostic and prognostic gap in the blanking period and increase active patient-involvement.
MediLinker: a blockchain-based decentralized health information management platform for patient-centric healthcare
Authors: Bautista John Robert , Harrell Daniel Toshio , Hanson Ladd , de Oliveira Eliel , Abdul-Moheeth Mustafa , Meyer Eric T. , Khurshid Anjum
Published: June 2023

Patients' control over how their health information is stored has been an ongoing issue in health informatics. Currently, most patients' health information is stored in centralized but siloed health information systems of healthcare institutions, rarely connected to or interoperable with other institutions outside of their specific health system. This centralized approach to the storage of health information is susceptible to breaches, though it can be mitigated using technology that allows for decentralized access. One promising technology that offers the possibility of decentralization, data protection, and interoperability is blockchain. In 2019, our interdisciplinary team from the University of Texas at Austin's Dell Medical School, School of Information, Department of Electrical and Computer Engineering, and Information Technology Services developed MediLinker—a blockchain-based decentralized health information management platform for patient-centric healthcare. This paper provides an overview of MediLinker and outlines its ongoing and future development and implementation. Overall, this paper contributes insights into the opportunities and challenges in developing and implementing blockchain-based technologies in healthcare.
Conodont biostratigraphy of a Carboniferous–Permian boundary section in siliceous successions of pelagic Panthalassa revealed by X-ray computed microtomography
Authors: Muto Shun , Takahashi Satoshi , Murayama Masafumi
Published: June 2023

Pelagic deep-sea siliceous successions in accretionary complexes preserve precious records of a vast deep seafloor that is now lost due to plate subduction. Microfossils are the key means of age assignment of these successions, but poor preservation due to tectonic deformation and metamorphism at the subduction zone hamper biostratigraphic records. X-ray computed microtomography, while not widely used in biostratigraphic studies until now, allows us to visualize fossils that are impossible or difficult to extract from host rocks due to poor preservation. In this study, we applied this method on conodonts from a pelagic chert–claystone succession in Okoshizawa, Iwaizumi Town, Northeast Japan, using a laboratory-based X-ray microscope. This work is a first close look at conodont biostratigraphy across the Carboniferous–Permian boundary in pelagic deep Panthalassa. We identified conodonts including ten species that are used as zonal markers in intensely studied areas such as around the East European Platform and Midcontinent United States. Based on the occurrence of conodonts, the studied section in Okoshizawa was correlated to the lower Moscovian to middle Artinskian. Confirmation of Moscovian to Artinskian age diagnostic conodonts from pelagic Panthalassa strengthens their role as global biostratigraphic indicators. By identifying more numerous specimens compared to the conventional hydrofluoric acid dissolution method, we were able to obtain information about conodont faunal characteristics around the Carboniferous–Permian boundary in pelagic deep areas of Panthalassa. The dominant taxa changed fromStreptognathodustoMesogondolellain the middle Asselian, probably reflecting an ecological takeover by the latter in the deep waters.
Numerical analysis and control technology of gas accumulation in a large-scale specially-shaped tunnel passing through coal bearing strata
Authors: Ma Shu , Mi Wansheng , Fan Shixing , Qiu Rui , Niu Gongqueshang
Published: June 2023

To solve the construction ventilation problem of super long (length greater than 10000 m) tunnel passing through discrete lenticular gas bag tunnel under complex working conditions in carbonaceous shale stratum, relying on the construction of Banzhulin tunnel of the new Xuyong-Bijie Railway (Sichuan-Yunnan). Using the finite element analysis software, the flow field distribution of the tunnel return air flow in the case of simultaneous excavation of multiple working faces is simulated, and the formation position and influence range of the vortex area which is easy to form gas accumulation are analyzed. On this basis, the technical team developed the PLC uninterruptible self starting ventilation power supply control program. By comparing the changes in the time required for ventilation power supply failure before and after the adoption of this technology, and the comparison of the gas concentration in the return air flow within a relatively short time of the failure, it is proved that this technology reduces the fault response time to 15.74% of the original time, and can well avoid gas accumulation within the failure time, It provides some reference for similar engineering construction.
Petrology and geochemistry of Li-bearing pegmatites and related granitic rocks in southern Thailand: implications for petrogenesis and lithium potential in Thailand
Authors: Fanka Alongkot , Tadthai Jaruphichaya
Published: June 2023

Lithium (Li) can be found in many minerals, including lepidolite. Lepidolite is found in pegmatite-related tin deposits in the Phang Nga area in southern Thailand. According to their field occurrence, petrography, mineral chemistry, and whole-rock geochemistry, the Li-bearing pegmatites and the granitic rocks in the study area can be linked to tin deposits in southern Thailand as part of the SE Asian tin belt. The Li-bearing pegmatites are characterized by an abundance of lepidolite, K-feldspar, plagioclase, and quartz with some accessory minerals of fluorite, cassiterite, apatite, monazite, and beryl. The granitic rocks show various compositions, including porphyritic biotite–muscovite granite, biotite granite, and muscovite—tourmaline granite with different proportions of K-feldspar, plagioclase, quartz, biotite, muscovite, and tourmaline. Whole-rock geochemistry indicates that both the Li-bearing pegmatites and granitic rocks have a close relationship rooted in their peraluminous S-type granite affinity. The Li-bearing pegmatites evolved from highly fractionated S-type granitic rocks comparable with the Western Belt Granite of Thailand. The enrichment of large-ion lithophile elements (e.g., Rb and K) and the depletion of Ba, Nb, and Ti together with similar rare Earth element patterns reflect the collisional setting indicating the Sibumasu–West Burma and West Burma—Indo-Burma collisions during the Cretaceous to the Eocene. The crystallization pressure—temperature conditions of these rocks were 3.49–4.25 kbar and 622°C–675°C, respectively, with an emplacement depth of 13–15 km. The Li-bearing pegmatites had a relatively high average Li grade compared with those of other Li-bearing pegmatites in the world.
MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population
Authors: Xu Xiaoyi , Xu Hangfei , Liu Xiaohui , Zhang Shuang , Cao Zhenhuan , Qiu Lixia , Du Xiaofei , Liu Yali , Wang Gang , Zhang Li , Zhang Yang , Zhang Jing
Published: June 2023

Background and aim

The MBOAT7 rs641738 (C>T) variant has demonstrated an association with non-alcoholic fatty liver disease (NAFLD) in both adult and pediatric patients, while few studies have been conducted in elderly populations. Hence, a case–control study was undertaken to assess their correlation in elderly residents in a Beijing community.

Materials and methods

A total of 1,287 participants were included. Medical history, abdominal ultrasound, and laboratory tests were recorded. Liver fat content and fibrosis stage were detected by Fibroscan. Genotyping of genomic DNA was performed using the 96.96 genotyping integrated fluidics circuit.

Results

Of the recruited subjects, 638 subjects (56.60%) had NAFLD, and 398 subjects (35.28%) had atherosclerotic cardiovascular disease (ASCVD). T allele carriage was associated with higher ALT (p=0.005) and significant fibrosis in male NAFLD patients (p=0.005) compared to CC genotype. TT genotype was associated with reduced risk of metabolic syndrome (OR=0.589, 95%CI: 0.114–0.683, p=0.005) and type 2 diabetes (OR=0.804, 95%CI: 0.277–0.296, p=0.048) in NAFLD population when compared to the CC genotype. In addition, TT genotype was also associated with reduced risk of ASCVD (OR=0.570, 95%CI:0.340–0.953, p=0.032) and less obesity (OR=0.545, 95%CI: 0.346–0.856, p=0.008) in the whole population.

Conclusion

MBOAT7 rs641738 (C>T) variant was associated with fibrosis in male NAFLD patients. The variant also reduced risk of metabolic traits and type 2 diabetes in NAFLD and ASCVD risk in Chinese elders.
Inter-annual sea level change and transgression along a barrier Island coast
Authors: Zarillo Gary A.
Published: June 2023

On the decadal time scale of coastal planning and management, relative sea-level rise is usually considered a trend or constant rate rather than a dynamic, time varying influence on coastal change. However, the coastal ocean sea level along the east coast of Florida and coastal regions further north is, to a first order, controlled at the interannual and decadal time scale by the dynamics of North Atlantic circulation and Gulf Stream (GS) flow, Every coastal region has its own distinctive annual sea-level cycle, and longer-term intra- and inter-decadal sea-level oscillations. This paper addresses the influence of the strong Florida coastal ocean sea-level signal on topographic evolution of the shoreface, coastal sediment budgets, and potential for coastal transgression at the decadal time scale.
Abnormal high tides and flooding induced by the internal surge in Hiroshima Bay due to a remote typhoon
Authors: Jeong Jae-Soon , Lee Han Soo , Mori Nobuhito
Published: June 2023

The Itsukushima Shrine is located in northern Hiroshima Bay in the Seto Inland Sea (SIS). This structure of great cultural value is preserved as one of the World Heritage Sites in Japan. The shrine was built seaside, 30 cm above the highest tide, to prevent it from submerging. However, from 2011 to 2019, the shrine was submerged four times during September due to internal surges. To study the abnormal tide event on 29 September 2011, a high-resolution numerical ocean circulation model was established using Semi-implicit Cross-scale Hydroscience Integrated System Model (SCHISM). Observed subtidal components of surface elevation in the northern part of the bay decreased due to northerly winds when the typhoon passed east off the bay. After 7–8 days of typhoon passage, the component increased abnormally in the northern part of the bay. Simulation results revealed that a destabilized density stratification by the typhoon winds most likely caused bay-scale internal waves. The internal wave developed after the typhoon passed and was caught from the kinetic energy filtered in the possible internal wave periods. The internal wave propagated southward after the typhoon passage and returned to the northern bay, causing the subtidal component to increase after 7–8 days. Sensitivity tests with various scales of the typhoon were performed, and the test results exhibited a positive relationship between the abnormal tide level and typhoon intensity to some extent. The results can be generally applied to a semi-closed bay or closed water body for internal wave generation and propagation under specific meteorological conditions for coastal protection and disaster prevention.
Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study
Authors: Xue Yan , Zhang Linzhu , Chen Yajun , Wang Han , Xie Jiang
Published: June 2023

Background

Accumulating evidence suggests that alterations in gut microbiota composition and diversity are associated with Atopic dermatitis (AD). But until now, the causal association between them has been unclear.

Methods

We employed a two-sample Mendelian Randomization (MR) study to estimate the potential causality of gut microbiota on AD risk. The summary statistics related to the gut microbiota were obtained from a large-scale genome-wide genotype and 16S fecal microbiome dataset from 18,340 individuals (24 cohorts) analyzed by the MiBioGen Consortium, comprising 211 gut microbiota. AD data were also derived from strictly defined AD data collected by FinnGen biobank analysis, which included 218,467 European ancestors (5,321 AD patients and 213,146 controls). The inverse variance weighted method (IVW), weighted median (WME), and MR-Egger were used to determine the changes of AD pathogenic bacterial taxa, followed by sensitivity analysis including horizontal pleiotropy analysis, Cochran’s Q test, and the leave-one-out method to assess the reliability of the results. In addition, MR Steiger’s test was used to test the suppositional relationship between exposure and outcome.

Results

A total of 2,289 SNPs (p < 1 × 10−5) were included, including 5 taxa and 17 bacterial characteristics (1 phylum, 3 classes, 1 order, 4 families, and 8 genera), after excluding the IVs with linkage disequilibrium (LD). Combining the analysis of the results of the IVW models, there were 6 biological taxa (2 families, and 4 genera) of the intestinal flora positively associated with the risk of AD and 7 biological taxa (1 phylum, 2 classes, 1 order, 1 family, and 2 genera) of the intestinal flora negatively associated. The IVW analysis results showed that Tenericutes, Mollicutes, Clostridia, Bifidobacteriaceae, Bifidobacteriales, Bifidobacterium, and Christensenellaceae R 7 group were negatively correlated with the risk of AD, while Clostridiaceae 1, Bacteroidaceae, Bacteroides, Anaerotruncus, the unknown genus, and Lachnospiraceae UCG001 showed the opposite trend. And the results of the sensitivity analysis were robust. MR Steiger’s test showed a potential causal relationship between the above intestinal flora and AD, but not vice versa.

Conclusion

The present MR analysis genetically suggests a causal relationship between changes in the abundance of the gut microbiota and AD risk, thus not only providing support for gut microecological therapy of AD but also laying the groundwork for further exploration of the mechanisms by which the gut microbiota contributes to the pathogenesis of AD.
A clinical study to evaluate the safe and effective use of a new, single use stethoscope cover to enable reduction in pathogen transmission during auscultation
Authors: Nazari-Shafti Timo Z. , Meyborg Heike , Iske Jasper , Schloss Maximilian , Seeber Fabian , Friedrich Aljona , Exarchos Vasileios , Richter Anja , Falk Volkmar , Emmert Maximilian Y.
Published: June 2023

Objectives

Stethoscopes carry a significant risk for pathogen transmission. Here, the safe use and performance of a new, non-sterile, single-use stethoscope cover (SC), that is impermeable for pathogens, was investigated by different healthcare professionals (HCPs) in the postoperative care setting of an intensive care unit (ICU).

Methods

Fifty-four patients underwent routine auscultations with the use of the SC (Stethoglove®, Stethoglove GmbH, Hamburg, Germany). The participating HCPs (n = 34) rated each auscultation with the SC on a 5-point Likert scale. The mean ratings of acoustic quality and the SC handling were defined as primary and secondary performance endpoint.

Results

534 auscultations with the SC were performed (average 15.7/user) on the lungs (36.1%), the abdomen (33.2%), the heart (28.8%), or other body-sites (1.9%). No adverse device-effects occurred. The acoustic quality was rated at 4.2 ± 0.7 (mean) with a total of 86.1% of all auscultations being rated at least as 4/5, and with no rating as below 2. The SC handling was rated at 3.7 ± 0.8 (mean) with a total of 96.4% of all auscultations being rated at least 3/5.

Conclusion

Using a real-world setting, this study demonstrates that the SC can be safely and effectively used as cover for stethoscopes during auscultation. The SC may therefore represent a useful and easy-to-implement tool for preventing stethoscope-mediated infections.

Study Registration: EUDAMED no. CIV-21-09-037762.
Changes in the morphology and cell ultrastructure of a microalgal community exposed to a commercial glyphosate formulation and a toxigenic cyanobacterium
Authors: Hernández-García Claudia Ivette , Martínez-Jerónimo Fernando
Published: June 2023

Human activities significantly influence the health of aquatic ecosystems because many noxious chemical wastes are discharged into freshwater bodies. Intensive agriculture contributes to the deterioration by providing indirectly fertilizers, pesticides, and other agrochemicals that affect the aquatic biota. Glyphosate is one of the most used herbicides worldwide, and microalgae are particularly sensitive to its formulation, inducing displacement of some green microalgae from the phytoplankton that leads to alterations in the floristic composition, which fosters the abundance of cyanobacteria, some of which can be toxigenic. The combination of chemical stressors such as glyphosate and biological ones, like cyanotoxins and other secondary metabolites of cyanobacteria, could induce a combined effect potentially more noxious to microalgae, affecting not only their growth but also their physiology and morphology. In this study, we evaluated the combined effect of glyphosate (Faena®) and a toxigenic cyanobacterium on the morphology and ultrastructure of microalgae in an experimental phytoplankton community. For this purpose, Microcystis aeruginosa (a cosmopolitan cyanobacterium that forms harmful blooms) and the microalgae Ankistrodesmus falcatus, Chlorella vulgaris, Pseudokirchneriella subcapitata, and Scenedesmus incrassatulus were cultivated, individually and jointly, exposing them to sub-inhibitory concentrations of glyphosate (IC10, IC20, and IC40). Effects were evaluated through scanning electron (SEM) and transmission electron (TEM) microscopy. Exposure to Faena® produced alterations in the external morphology and ultrastructure of microalgae both individually and in combined cultures. SEM evidenced the loss of the typical shape and integrity of the cell wall and an increase in the biovolume. TEM revealed reduction and disorganization of the chloroplast, variation in starch and polyphosphate granules, formation of vesicles and vacuoles, cytoplasm degradation, and cell wall continuity loss. The presence of M. aeruginosa was, for microalgae, an additional stress factor adding to the chemical stress produced by Faena®, increasing the damage in their morphology and ultrastructure. These results alert to the effects that can be caused by glyphosate and the presence of toxigenic bacteria on the algal phytoplankton in contaminated and anthropic and eutrophic freshwater ecosystems.
Cerebellar functional connectivity change is associated with motor and neuropsychological function in early stage drug-naïve patients with Parkinson’s disease
Authors: Jiang Li , Zhuo Jiachen , Furman Andrew , Fishman Paul S. , Gullapalli Rao
Published: June 2023

Introduction

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder affecting both motor and cognitive function. Previous neuroimaging studies have reported altered functional connectivity (FC) in distributed functional networks. However, most neuroimaging studies focused on patients at an advanced stage and with antiparkinsonian medication. This study aims to conduct a cross-sectional study on cerebellar FC changes in early-stage drug-naïve PD patients and its association with motor and cognitive function.

Methods

Twenty-nine early-stage drug-naïve PD patients and 20 healthy controls (HCs) with resting-state fMRI data and motor UPDRS and neuropsychological cognitive data were extracted from the Parkinson’s Progression Markers Initiative (PPMI) archives. We used seed-based resting-state fMRI (rs-fMRI) FC analysis and the cerebellar seeds were defined based on the hierarchical parcellation of the cerebellum (AAL atlas) and its topological function mapping (motor cerebellum and non-motor cerebellum).

Results

The early stage drug-naïve PD patients had significant differences in cerebellar FC when compared with HCs. Our findings include: (1) Increased intra-cerebellar FC within motor cerebellum, (2) increase motor cerebellar FC in inferior temporal gyrus and lateral occipital gyrus within ventral visual pathway and decreased motor-cerebellar FC in cuneus and dorsal posterior precuneus within dorsal visual pathway, (3) increased non-motor cerebellar FC in attention, language, and visual cortical networks, (4) increased vermal FC in somatomotor cortical network, and (5) decreased non-motor and vermal FC within brainstem, thalamus and hippocampus. Enhanced FC within motor cerebellum is positively associated with the MDS-UPDRS motor score and enhanced non-motor FC and vermal FC is negatively associated with cognitive function test scores of SDM and SFT.

Conclusion

These findings provide support for the involvement of cerebellum at an early stage and prior to clinical presentation of non-motor features of the disease in PD patients.
NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial
Authors: Gérain Jean , Uebelhoer Melanie , Costes Bérénice , Herman Julie , Pietri Sandra , Donneau Anne-Françoise , Monseur Justine , Henrotin Yves
Published: June 2023

Objectives

The effect and safety of Nasafytol®, a food supplement combining curcumin, quercetin, and Vitamin D, on hospitalized COVID-19-positive patients as support to standard of care were to be assessed.

Methods

This exploratory, open-label, randomized, controlled trial was carried out among hospitalized adults with COVID-19 infection. Participants were randomly assigned to receive Nasafytol® or Fultium® control. The improvement of the clinical condition and occurrence of (serious) adverse events were evaluated. The study was registered on clincaltrials.gov with the identifier NCT04844658.

Results

Twenty-five patients received Nasafytol®, and 24 received Fultium®. Demographic characteristics were well balanced between the groups. On day 14 (or at hospital leave if < 14 days), no difference was observed between groups regarding their clinical condition, fever, or the need of oxygen therapy. At day 7, however, 19 participants had been discharged from the hospital in the Nasafytol® arm compared to 10 participants in the Fultium® arm. No participants were transferred to the ICU or died in the Nasafytol® arm, vs. 4 transfers and 1 death in the Fultium® arm. The clinical condition of participants in the Nasafytol® arm had improved, as evidenced by a decrease in the COVID-19 WHO score. Interestingly, five SAEs occurred with Fultium®, while no SAE was observed with Nasafytol®.

Conclusion

Supplementation with Nasafytol®, in addition to standard-of-care treatment, led to a faster discharge from the hospital, improved clinical conditions of participants, and a reduced risk of serious outcomes, including transfer to the intensive care unit or death, in patients hospitalized with COVID-19.
You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasis
Authors: Cozzo Alyssa J. , Coleman Michael F. , Hursting Stephen D.
Published: June 2023

Every cancer genome is unique, resulting in potentially near infinite cancer cell phenotypes and an inability to predict clinical outcomes in most cases. Despite this profound genomic heterogeneity, many cancer types and subtypes display a non-random distribution of metastasis to distant organs, a phenomenon known as organotropism. Proposed factors in metastatic organotropism include hematogenous versus lymphatic dissemination, the circulation pattern of the tissue of origin, tumor-intrinsic factors, compatibility with established organ-specific niches, long-range induction of premetastatic niche formation, and so-called “prometastatic niches” that facilitate successful colonization of the secondary site following extravasation. To successfully complete the steps required for distant metastasis, cancer cells must evade immunosurveillance and survive in multiple new and hostile environments. Despite substantial advances in our understanding of the biology underlying malignancy, many of the mechanisms used by cancer cells to survive the metastatic journey remain a mystery. This review synthesizes the rapidly growing body of literature demonstrating the relevance of an unusual cell type known as “fusion hybrid” cells to many of the hallmarks of cancer, including tumor heterogeneity, metastatic conversion, survival in circulation, and metastatic organotropism. Whereas the concept of fusion between tumor cells and blood cells was initially proposed over a century ago, only recently have technological advancements allowed for detection of cells containing components of both immune and neoplastic cells within primary and metastatic lesions as well as among circulating malignant cells. Specifically, heterotypic fusion of cancer cells with monocytes and macrophages results in a highly heterogeneous population of hybrid daughter cells with enhanced malignant potential. Proposed mechanisms behind these findings include rapid, massive genome rearrangement during nuclear fusion and/or acquisition of monocyte/macrophage features such as migratory and invasive capability, immune privilege, immune cell trafficking and homing, and others. Rapid acquisition of these cellular traits may increase the likelihood of both escape from the primary tumor site and extravasation of hybrid cells at a secondary location that is amenable to colonization by that particular hybrid phenotype, providing a partial explanation for the patterns observed in some cancers with regard to sites of distant metastases.
Sport activities for children and adolescents: the Position of the European Academy of Paediatrics and the European Confederation of Primary Care Paediatricians 2023—Part 1. Pre-participation physical evaluation in young athletes
Authors: Turska-Kmieć Anna , Neunhaeuserer Daniel , Mazur Artur , Dembiński Łukasz , del Torso Stefano , Grossman Zachi , Barak Shimon , Hadjipanayis Adamos , Peregud-Pogorzelski Jarosław , Kostka Tomasz , Bugajski Andrzej , Huss Gottfried , Kowalczyk-Domagała Monika , Wyszyńska Justyna
Published: June 2023

The European Academy of Paediatrics (EAP) and the European Confederation of Primary Care Paediatricians (ECPCP) emphasize the importance of promoting healthy lifestyles within the pediatric population. Many health professionals have questions concerning adequate levels of physical activity for both the healthy pediatric population and for those who may have specific complications. Unfortunately, the academic literature that provides recommendations for participation in sport activities within the pediatric population that have been published during the last decade in Europe is limited and is mainly dedicated to specific illnesses or advanced athletes and not toward the general population. The aim of part 1 of the EAP and ECPCP position statement is to assist healthcare professionals in implementing the best management strategies for a pre-participation evaluation (PPE) for participation in sports for individual children and adolescents. In the absence of a uniform protocol, it is necessary to respect physician autonomy for choosing and implementing the most appropriate and familiar PPE screening strategy and to discuss the decisions made with young athletes and their families. This first part of the Position Statement concerning Sport Activities for Children and Adolescents is dedicated to healthy young athletes.
Screening for early warning of psychological crisis and intervention in children aged 8–18 years with cancer: a historical controlled trial
Authors: Yu Lu , Mo Lin , Liu Yixuan , Huang Xiaoyan
Published: June 2023

Background

Childhood cancer is becoming an emerging healthcare issue in mainland China. Extensive evidence in the literature has demonstrated that cancer and its treatment experience can cause psychological distress that can lead to developmental problems in children with cancer. This study aims to screen for early warning of psychological crisis in children aged 8–18 years with cancer, establish a model of early warning intervention for children with cancer, and explore its application effects.

Methods

We recruited 345 children with cancer and aged 8–18 years as the study participants, of whom 173 children were selected as historical controls during the period between December 2019 and March 2020 and 172 children were selected as the intervention group during the period between July 2020 and October 2020. The routine nursing model was adopted for the control group, and the early warning and intervention model was applied for the intervention group. The early warning and intervention model consisted of four stages: (1) establishing a management team to assess the risk of psychological crisis, (2) developing a three-level early warning response mechanism, (3) developing specific response plans, and (4) creating an evaluation summary and optimization mode. The DASS-21 was used to evaluate the psychological status of children with cancer before and 3 months after the intervention.

Results

The average age of the control group was 11.43 ± 2.39 years, with 58.96% boys and 61.27% diagnosed with leukemia. The average age of the intervention group was 11.62 ± 2.31 years, with 58.72% boys and 61.63% diagnosed with leukemia. There was a significant reduction in depressive symptoms (4.91 ± 3.98, t = 12.144, P < 0.05), anxiety symptoms (5.79 ± 4.34, t = 8.098, P < 0.05), and stress symptoms (6.98 ± 4.67, t = 11.22, P < 0.05) in the intervention group. The incidence rates of depression, anxiety, and stress were significantly lower in the intervention group (12.79%, 29.07%, and 5.23%, respectively) than in the control group (46.82%, 49.71%, and 27.17%, respectively) (all P's < 0.05).

Conclusions

Our study suggests that the early detection and timely management of psychological symptoms through a nursing intervention model can effectively reduce depressive, anxiety, and stress symptoms in Chinese children with cancer. Future work should include conducting qualitative interviews to understand the psychological experiences of children with cancer throughout their entire life cycle.
Clinical analysis and medium-term follow-up of simultaneous interventional therapy for compound congenital heart disease in children: a single-center retrospective study
Authors: Ran Tingting , Feng Lingxin , Li Mi , Yi Qijian , Zhu Xu , Ji Xiaojuan
Published: June 2023

Objective

This study aimed to explore the safety and efficacy of simultaneous interventional therapy for compound congenital heart disease (CCHD) in children.

Methods

In total, 155 children with CCHD who received simultaneous interventional therapy at the Children's Hospital of Chongqing Medical University between January 2007 and December 2021 were included in study. Data on clinical manifestations, transthoracic echocardiography, electrocardiogram, and follow-up were retrospectively analyzed.

Results

The most common type of CCHD was atrial septal defect (ASD) combined with ventricular septal defect (VSD), accounting for 32.3% of the patients. Simultaneous interventional therapy was successfully administered to 151 children (97.4%). The pulmonary gradient of patients with pulmonary stenosis decreased from 47.3 ± 21.9 mmHg to 15.2 ± 12.2 mmHg (P < 0.05) immediately after the procedure. One patient had failed PBPV as he had residual PS >40 mmHg post procedure. The right ventricular dimension and left ventricular end-diastolic dimension significantly decreased in the first month after the procedure in patients with ASD combined with VSD. Twenty-five (16.1%) patients had mild residual shunt, which spontaneously disappeared in more than half of these patients 6 months after the procedure. The major adverse events were minimal (n = 4, 2.58%), including one patient requiring drug treatment for complete atrioventricular block and three patients receiving surgical treatment because of cardiac erosion, anterior tricuspid valve chordae rupture, and hemolysis, respectively.

Conclusions

ASD combined with VSD is the most common type of CCHD in children, and simultaneous interventional therapy for CCHD in children is safe and effective with satisfactory results. Ventricular remodeling can be reversed in patients with ASD combined with VSD 1 month after the procedure. Most adverse events associated with interventional therapy are mild and manageable.
Enhanced laser-driven backward proton acceleration using micro-wire array targets
Authors: Fan Lulin , Xu Tongjun , Wang Qingsong , Xu Jiancai , Zhang Guoqiang , Wang Putong , Fu Changbo , Ma Zhiguo , Deng Xiangai , Ma Yugang , Li Shun , Lu Xiaoming , Li Jinfeng , Xu Rongjie , Wang Cheng , Liang Xiaoyan , Leng Yuxin , Shen Baifei , Ji Liangliang , Li Ruxin
Published: June 2023

Micro-structured targets can be employed to enhance the coupling of laser energy to the high energy density plasma. Here we report on experimental measurement of enhanced proton beam energy from laser-driven micro-wire array (MWA) targets along the backward direction. An ultra-intense (∼2×1020W/cm2) laser pulse of ∼ 40 fs pulse duration interacts with the MWA structure and induces large population of energetic electrons. The enhanced sheath field efficiently accelerates protons both transversely and longitudinally. The spectrometers record proton cut-off energy of around 16 MeV and temperature 813keV along the backward direction, which is 20%−60% higher than that of a flat target under commensurate laser conditions. Comparison with particle-in-cell simulations suggests that the enhancement originates from the increased temperature and population of the hot electrons within the micro-wires. These measurements provide a direct probe of the high energy density plasma condition in laser-driven solid targets and a useful benchmark for further studies on laser-driven micro-structured targets.