bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of Intervention Program to Prevent Adolescent Health-Compromising Behaviors
Authors: Lee Chia-Kuei , Liao Li-Ling
Published: October 2021

Most people start experimenting with and/or initiating health-compromising behaviors and establishing behavioral patterns during adolescence. Possible selves and episodic future thinking have been used to foster behavioral changes. In this study, we aimed to (1) develop a program incorporating possible selves and episodic future thinking to decrease the risks associated with health-compromising behaviors, and (2) examine the feasibility and fidelity of implementing this intervention among Taiwanese adolescents. A novel combination of existing intervention approaches tailored for the Taiwanese context was applied to develop a school-based intervention, which we named the Future Mapping Master program. This program contains four core units: exploring the self, setting goals, developing strategies and problem solving, and understanding the threats of health-compromising behaviors. It includes daily episodic future thinking visualization exercises. The feasibility evaluation was conducted with 88 adolescents aged 12–14 years. Feedback from teachers and students supported the proposed program's feasibility and revealed favorable reactions to the intervention. The Future Mapping Master program is feasible and offers promising strategies for implementation in Taiwanese school settings.
Sexual Harassment in the Academy: Harnessing the Growing Labor Movement in Higher Education to Address Sexual Harassment Against Graduate Workers
Authors: O’Callaghan Erin , Shepp Veronica , Kirkner Anne , Lorenz Katherine
Published: October 2021

Higher education is not immune to the epidemic of sexual harassment in the United States, particularly sexual harassment of graduate workers. This is due largely to power differentials of status and income, as academia relies on low-wage work. While the literature shows sexual harassment is prevalent across disciplines, current work to address the problem does not account for graduate worker precarity. The graduate labor movement, which addresses precarity, is beginning to tackle sexual harassment. We review how the labor and anti-gender-based violence movements in higher education should come together to prevent sexual harassment, presenting recommendations for structural changes to academia.
Patient satisfaction and behavioural intention in using the home medication delivery service in an ambulatory oncology centre
Authors: Leow Jo Lene , Lin Keegan , Chew Lita
Published: October 2021

Background

The COVID-19 pandemic has increased usage of medication delivery service (MDS) significantly. MDS improves adherence to medication and clinical outcomes.

Objectives

To study behavioral change factors that affect adoption of MDS, determine existing patient satisfaction level, and make recommendations to improve MDS adoption.

Methods

A single-institution, cross-sectional survey was conducted at the outpatient pharmacy of the largest ambulatory cancer centre in Singapore. The survey consisted of sections on demographics, Theory of Planned Behavior constructs and patient satisfaction questions. Descriptive analysis and logistic regression were used.

Results

A total of 881 patients responded. Respondents were mostly Chinese, female and subsidized patients, with a mean age of 62.4 years old. MDS use is strongly predicted by favourable attitude (OR 3.54, 95%CI 2.64–4.75; p < 0.001) and subjective norm (OR 3.07, 95%CI 2.30–4.09; p < 0.001) towards its use and greater perceived behavioral control (OR 2.48; 95%CI 1.86–3.30; p < 0.001). Being ill or frail has been identified as facilitators, while absence of face-to-face consultation and cost of delivery were barriers to the adoption of MDS. Encouragingly, the satisfaction level of our existing patients was generally high (80.2, SD16.7). Recommendation to improve MDS adoption targets facilitators and barriers identified and aims to further elevate patient satisfaction level. Establishment of a centralised pharmacy for MDS together with a call centre would be essential in the long run.

Conclusions

MDS is becoming increasingly important, in line with our national strategy. Implementation of suggested short-term and long-term measures will encourage its use.
Don’t Pass Deferred Maintenance Costs to the Next Generation! The Effects of Politics on State Highway Maintenance Spending
Authors: Kim Jiseul
Published: October 2021

Routine maintenance spending for public infrastructure is critical for reducing life-cycle costs, and improving asset preservation and quality. Yet, states focus more on building new roads and expansion than maintaining existing assets’ conditions. Deferred maintenance costs are transferred to the future taxpayers, and they will eventually pay the expensive price. So far, there is little academic endeavor to examine the determinants of state and local routine maintenance spending. This study uses a panel data analysis covering 47 states from 1995 to 2009 to examine the effects of politics on state highway routine maintenance spending. The study finds that political incentive and conflict are key factors delaying state highway routine maintenance spending. The re-election-minded governors and legislatures tend to allocate less funding to maintenance to satisfy the current taxpayers. The study further finds that politically-divided states spend less on highway maintenance due to higher transaction costs in the policy-making process.
Intestinal dehiscence and mortality in cats undergoing gastrointestinal surgery
Authors: Hiebert Elizabeth C , Barry Sabrina L , Sawyere Dominique M , DeMonaco Stefanie M , Muro Noelle M
Published: October 2021

Objectives

The aim of this study was to determine the incidence of and risk factors for both gastrointestinal (GI) incisional dehiscence and mortality in a large cohort of cats undergoing GI surgery. We hypothesized that cats with preoperative septic peritonitis (PSP), systemic inflammatory response syndrome (SIRS) or sepsis would have higher GI dehiscence and mortality rates than unaffected cats.

Methods

A medical records search identified cats with surgically created, full-thickness incisions into their stomach, small intestines or large intestines. Preoperative data, including signalment, clinical signs, comorbidities, surgical history, current medications, presenting physical examination findings, complete blood counts and serum biochemistry values, were collected. It was determined whether or not cats had PSP, SIRS or sepsis at admission. Intraoperative data, final diagnosis and postoperative variables such as vital parameters, bloodwork and (if applicable) the development of GI dehiscence or mortality were noted. Postoperative follow-up of at least 10 days was obtained in survivors.

Results

In total, 126 cats were included. One cat developed GI dehiscence following complete resection of a jejunal adenocarcinoma. Twenty-three cats (18.2%) died within 10 days of surgery. Cats with PSP ( P = 0.0462) or that developed hypothermia 25–72 h postoperatively ( P = 0.0055) had higher odds of mortality in multivariate analysis. Cats with PSP had 6.7-times higher odds of mortality than cats not diagnosed with PSP.

Conclusions and relevance

In cats receiving GI surgery, the incidence of GI incisional dehiscence was <1%. Cats with PSP had a higher likelihood of mortality. SIRS was a common finding in cats with septic peritonitis, but was not associated with mortality. Postoperative mortality during the home recovery period might be significant in cats. Future studies evaluating postoperative mortality in cats should consider extending the research period beyond the date of discharge.
COVID-19 Skin Manifestations in Skin of Colour
Authors: Akuffo-Addo Edgar , Nicholas Mathew N. , Joseph Marissa
Published: October 2021

Coronavirus disease (COVID-19) skin manifestations have been increasingly reported in medical literature. Recent discussions have identified a lack of images of skin of color (SOC) patients with COVID-19 related skin findings despite people with skin of color being disproportionately affected with the disease. There have been calls to prioritize the identification of COVID-19 skin manifestations in patients with SOC and disseminate these findings. The objective of this article is to review the existing literature on COVID-19 skin manifestations and, where possible, discuss how they may present differently in patients with SOC. Further research is needed to allow primary care physicians and dermatologists to be aware of and easily identify patients with cutaneous findings that may be secondary to COVID-19. Patients presenting with idiopathic dermatologic manifestations should be considered for COVID-19 testing and follow public health guidelines for self-isolation.
Taking stock of “Organizational Learning”: Looking back and moving forward
Authors: Elkjaer Bente
Published: October 2021

In what ways are organizational learning a relevant theoretical construct? The article taps into a debate on what is relevance to practitioners versus researchers’ responsibility. The publications on organizational learning are on the rise, but the patterns have changed and points to a bifurcation within the field of organizational learning. On one hand, organizational learning is a means to further organizational performance, a fixed goal to be measured, which sometimes demands unlearning. On the other hand, there is a call for organizational learning to be encompassing contemporary societal challenges like widespread digitalization, sustainable production, and an inclusive labor market. This may appear as a cleavage between immediate relevance to practitioners and researchers’ responsibilities for the development of relevant and critical knowledge. I propose to embrace a pragmatist theory of learning that can help address the unknown and include creative imagination directed toward developing an organizational learning field, which is also ready for the future.
Party regulation in Latin America: A change of normative paradigms
Authors: Scherlis Gerardo
Published: October 2021

In spite of the growing academic interest in party law in Latin America, we still lack a comprehensive account of how party regulatory frameworks evolved from the time of transitions to the present. This paper aims to fill this gap. In doing so, it makes a double contribution to the field of party regulation. On the one hand, it systematizes, for the first time, all the reforms adopted in Latin America over the last four decades. On the other hand, it introduces a theoretical innovation by using the concept of normative paradigms to analyze a process of legislative change. The main argument of this article is that a permissive paradigm was gradually but overwhelmingly replaced by a prescriptive approach, which conceives parties as semi-state institutions. This shift sheds light on the changing linkages between parties and the state in Latin America.
Children's playful musicking: Peer culture within a day-care setting in Singapore
Authors: Lim Sirene
Published: October 2021

In the field of early childhood education, play has become synonymous with curriculum but is sometimes viewed narrowly as a pedagogical tool to enhance child development. However, it is known from a range of multidisciplinary work that child-initiated and child-guided forms and contexts of playing can offer rich insight into diversity in childhood(s), peer cultures and children's meaning-making. This article draws on an ethnographic study that was conducted in a full-day childcare centre in Singapore and focused on children's everyday world of self-initiated play, improvisation and peer culture. Specifically, it presents examples of songs and rhythmic chants created by a group of 4-year-olds . Such ‘musicking’ is a form of social play that illustrates children’s ways of teasing, relating with others and sense-making within their contemporary social world. The article argues for educators to look beyond the instrumental value of play in the preschool curriculum, inviting all to take some time to allow children's multifarious play activities to influence their adult sensibilities.
Emotions, feelings, and moods in tourism and hospitality research: Conceptual and methodological differences
Authors: Godovykh Maksim , Tasci Asli DA
Published: October 2021

Researchers often tend to use the words emotions, feelings, moods, and affect interchangeably, which creates confusion in both conceptual and methodological domains of tourism and hospitality research. However, the insights from neuroscience and psychology demonstrated that there are fundamental differences between these concepts, including their causes, duration, intensity, and outcomes. This research note aims to discuss conceptual and methodological aspects related to using emotions, moods, feelings, and affect, provide comprehensive definitions, and outline opportunities to capture them comprehensively in tourism and hospitality research.
Effect of nano-solid particles on the mechanical properties of shear thickening fluid (STF) and STF-Kevlar composite fabric
Authors: Zhao Mingmei , Zhang Jinqiu , Peng Zhizhao , Zhang Jian
Published: October 2021

To analyze the effect of nano-solid particles on the mechanical properties of shear thickening fluid (STF) and its Kevlar composite fabric. In this study, nano-silica and polyethylene glycol (PEG 200) were used as dispersed and continuous phases. Nano-graphite and nano-diamond particles were used as additives to prepare STF and Kevlar composite fabric. Study the friction characteristics and rheological characteristics of STF at different temperatures. Explore the STF’s mechanical response under transient high-speed impact conditions through the split Hopkinson pressure bar experiment. The mechanical properties of STF-Kevlar fabric are studied through yarn pull-out test and burst experiments. The experimental results show that the intermolecular repulsive force of STF is enhanced under a high-temperature environment, and shear thickening effect is reduced. Nano-diamond particles strengthen the contact coupling force and contact probability between the particle clusters, so that the maximum viscosity of the system reaches 1679 Pa s, the thickening ratio reaches 318 times, and the rheological properties of the shear thickening fluid are improved. The results of the SHPB experiment show that the STF can complete a dynamic response within a 50–75 µs time range, and the maximum stress can reach 78 MPa. The bullet’s incident kinetic energy is not only transformed into thermal energy and phase change energy of solid-liquid conversion, but also into frictional energy between particles. The mechanical experiments of STF-Kevlar composite fabrics show that the tensile force value of STF5-Kevlar is the largest (10.3 N/13.5 N), and the tensile force of neat Kevlar was the smallest (4.3 N/4.9 N). The maximum bearing capacity (0.3 kN) and absorption energy (51.8 J) of Neat Kevlar are less than those of STF1-Kevlar (3.2 kN, 116.7 J) and STF3-Kevlar (1.9 kN, 88.2 J), and STF5-Kevlar (4.7 kN, 143.3 J). Fabric’s failure mode is converted from partial yarn extraction to overall deformation and rupture of the fabric. Therefore, by changing the solid additives’ parameters, the STF and the composite fabric’s mechanical properties can be effectively controlled, which provides a reference for preparing the STF and fabric composite materials.
Approaching the Social Impact of Research Through a Literature Review
Authors: Viana-Lora Alba , Nel-lo-Andreu Marta Gemma
Published: October 2021

The article carries out a systematic literature review on the social impact of research in all fields of study. To this end, this study has compiled the publications on the subject using the Web of Science database, and the most relevant terms have been mapped using the VOSviewer tool. The aim of the article is to advance and provide knowledge on the key aspects to be taken into account for research to generate social benefits and to analyse the main methods and instruments used to assess the social impact of research. At the same time, this article serves as a point of reflection to raise awareness, on a recent topic, of the limitations that arise in evaluation and research gaps that can be addressed in future research. This line of research has been in existence for just over 10 years. International programmes, such as Horizon Europe, highlight the impact channels and, in the field of social sciences, specific methodologies such as communicative communication are being developed. To the best of our knowledge, this is the first study to analyse the subject from a global point of view, without specifying the field of study, providing a conceptual map of the subject.
RAM analysis of dynamic positioning system: An approach taking into account uncertainties and criticality equipment ratings
Authors: Clavijo Maria V , Schleder Adriana M , Droguett Enrique Lopez , Martins Marcelo R
Published: October 2021

Currently, a Dynamic Position (DP) System is commonly used for offshore operations. However, DP failures may generate environmental and economic losses; thus, this paper presents the Reliability, Availability and Maintainability (RAM) analysis for two different generations of DP system (DP2 and DP3) used in drilling operations. In addition to the RAM analysis, the approach proposed herein considers the uncertainties present in the equipment failure data and provides more information about criticality equipment ratings and probability density functions (pdf) of the repair times. The reliability analysis shows that, for 3 months of operation, the total failure probability of the DP2 system is 1.52% whereas this probability for the DP3 system is only 0.16%. The results reveal that the bus-bar is the most critical equipment of the DP2 system, whereas the wind sensor represents the priority equipment in the DP3 system. Using 90% confidence level, each DP configuration was evaluated for a 1-year operation, finding a reliability mean equal to 70.39% and 86.77% for the DP2 system and the DP3 system, respectively. The DP2 system asymptotic availability tends to present a constant value of 99.98% whereas for the DP3 system, it tends to be 99.99%. Finally, the maintainability analysis allows concluding that the mean time for system repair is expected to be 3.6 h. This paper presents a logical pathway for analysts, operators, and reliability engineers of the oil and gas industry.
‘To get or not to get vaccinated against COVID-19’: Saudi women, vaccine hesitancy, and framing effects
Authors: Abdel-Raheem Ahmed , Alkhammash Reem
Published: October 2021

The use of language and images in the media may have a strong effect on people’s political cognition. In this regard, conspiracy theories and misinformation about the COVID-19 vaccine can lead to reluctant uptake of the vaccine even among medical staff. In two experiments, this article tests the hypothesis that the public’s willingness to get vaccinated against the novel coronavirus depends on the framings they are presented with. Two hundred thirty-two female Saudi students are exposed to either pro- or anti-vaccination messages. In Experiment 1, they are asked to read semi-artificial news stories, and in Experiment 2 political cartoons. The results show that readers of the news articles, but not of the cartoons, are susceptible to framing effects. We consider the implications of how issues are framed for journalists and health professionals.
Clavicular osteotomy to assess subclavian vein injury during internal fixation of midshaft clavicle fractures
Authors: Rawal Aziz , Mannambeth Rejith , Murray Simon , Moaveni Ash
Published: October 2021

Midshaft clavicle fractures are commonly fixed with locking plates. The subclavian vein risks injury during this procedure and the consequences can be fatal. The purpose of this present study is to describe a clavicular osteotomy technique in order to equip orthopaedic surgeons with a means of rapidly accessing a subclavian vein injury. The osteotomy should only be performed following an urgent intraoperative vascular surgery assessment. There must be shared consensus from both orthopaedic and vascular surgery that direct repair of the subclavian vein is necessary, and further exposure is required. The results of the technique performed on thirteen embalmed cadaveric specimens are also included. The osteotomy was able to expose 3.16 cm (SD = 0.60) of the subclavian vein and both the fracture and osteotomy site of all clavicles (100%) were able to be reduced and fixed using a single pre-contoured fifteen-hole lateral plate intended for use on the contralateral shoulder. This surgical technique study confirms that in the rare circumstance that the osteotomy is utilized, adequate exposure of the subclavian vein is achieved.
Policies and Price Tags: The Public’s Perception of Face Transplantation and Its Funding
Authors: Abousy Mya , Jenny Hillary , Xun Helen , Khavanin Nima , Creighton Francis , Byrne Patrick , Cooney Damon , Redett Richard , Yang Robin
Published: October 2021

Study Design:

Survey study.

Objective:

Facial vascularized composite allotransplantation (FVCA) can cost over 1 million dollars per procedure and is usually not covered by insurance, yet this financial burden and public opinion surrounding this procedure are not well understood. This study is the first to evaluate the layperson’s opinions on the allocation of financial responsibility for FVCA and its inclusion in organ donation registries.

Methods:

Eight hundred and fifteen laypersons were surveyed through MTurk to assess their agreement with 11 statements about FVCA perceptions, funding, and inclusion on organ donation registries. Responses were analyzed with the Wilcoxon Signed-Rank test, the Kruskal-Wallis test, and the Dunn’s test.

Results:

The majority of respondents were supportive of FVCA in 10 out of 11 statements ( P < 0.0001). They would be willing to undergo FVCA if they suffered from facial disfigurement; believe FVCA is as important as other organ transplants; believe faces should be included on the organ donation registry; support insurance companies providing coverage for FVCA regardless of trauma etiology; support tax dollars funding the procedure; and believe FVCA improves physical appearance and quality of life. Although respondents generally supported their tax dollars funding the procedure, fewer supported this for self-inflicted trauma ( P > 0.01).

Conclusions:

This study highlights a disconnect between public preference for insurance coverage of FVCA and current lack of coverage in practice. Respondents’ acceptance of including faces in organ donation registries may help alleviate the issue of locating a donor, and increasing financial coverage may broaden this procedure’s accessibility to a wider range of individuals.
Cryptococcosis as a complication of therapy for sarcoidosis: A case report
Authors: Shi Jiejun , Zhou Lei , Ma Ada Hoi Yan , Yang Naibin , Chen Lei , Qian Guoqing
Published: October 2021

Cryptococcosis is a rare complication of sarcoidosis, especially when it grows in lungs. It may escape from being diagnosed because of low prevalence and non-specific radiological presentation. Hereby, we reported an unusual case of pulmonary cryptococcosis secondary to the long-term use of glucocorticoids to treat sarcoidosis which can be misdiagnosed as progression of sarcoidosis due to the similar radiological presentation. After targeted therapy with fluconazole for 5 months, her chest computed tomography rescan revealed resolution of the pulmonary lesions.
Ultrasound features of polypoid endometriosis: a case report and a short review of Literature
Authors: Mancarella Matteo , Sgro Luca Giuseppe , Fuso Luca , Campisi Paola , Biglia Nicoletta , Mariani Luca Liban
Published: October 2021

Introduction:

Polypoid endometriosis is a rare variant of endometriosis characterized by histological features resembling an endometrial polyp. Lesions frequently affect the ovaries presenting as adnexal masses which may mimic malignancy, with an extremely complex differential diagnosis due to the poor evidence reported in Literature.

Case description:

In this report, we describe the case of a 43 years old woman referred to pelvic transvaginal ultrasound examination for recurrent abdominal pain, in whom sonography revealed a pelvic mass with features highly suspicious for ovarian carcinoma. Surgical removal allowed histopathological diagnosis of polypoid endometriosis, with no signs of malignancy. At ultrasound examination, the lesion appeared as a multilocular-solid mass, with low-level echogenicity of cystic content, multiple papillary projections, and solid areas with high vascularization and apparent infiltration of the uterus. At retrospective review of the sonographic images after pathological examination, some features mirroring the histological architecture of polypoid endometriosis could be identified in the solid components of the mass: these included the hyperechoic appearance, the rounded outline of the intracystic projections, and the vascularization pattern with a single central vessel with branching.

Conclusions:

To date, this is the first work providing a detailed ultrasonographic description of polypoid endometriosis using shared terms and definitions and relating these findings with available evidence about radiologic and histopathologic features. The report shows how this condition could strongly mimick ovarian malignancy, though several sonographic features can be identified reflecting the histopathological patterns of those lesions.
Does the Route of Cocaine Use Affect the Mortality and Outcomes of Cocaine-Induced Intestinal Ischemia? A Systematic Review
Authors: Farooq Umer , Gondal Amlish B. , Susheela Ammu , Tarar Zahid Ijaz , Malik Adnan , Zafar Muhammad Usman , Sharif Aftab , Ghous Ghulam
Published: October 2021

Intestinal ischemia results from diminished perfusion of the colon resulting in tissue hypoxia. Anecdotal reports suggest that cocaine-induced intestinal ischemia has the highest mortality and longer length of stay among the vasoconstrictors. The present study aimed to summarize the available studies in the literature to assess the effect of routes of consumption on the outcomes of cocaine-induced intestinal ischemia. We conducted a systematic search of MEDLINE from inception through October 2019. Studies of cocaine-induced intestinal ischemia were included if data were available on comorbidities, mortality, and hospital length of stay (LOS). The study’s primary outcomes were mortality and need for surgery, while secondary outcomes included the hospital length of stay, LACE index, and hospital score. Statistical tests used included linear and binary logistic regression. STATA 2015 was used, and P < 0.05 was statistically significant. Of the 304 studies, 8 case series and 45 case reports (n = 69 patients) met the inclusion criteria. Different routes of cocaine use had similar mortality odds and the need for surgery for intestinal ischemia. Hospital LOS showed significant difference among the subgroups. Readmission scores (LACE and hospital score) were higher for intravenous and smoking than ingestion and intranasal use ( P < 0.05). In conclusion, different routes of cocaine use appear to have similar mortality odds for intestinal ischemia, which vary significantly among the different routes of cocaine consumption for the length of stay and readmission scores. Prompt recognition of the route of cocaine use is vital to improve the outcome. Large-scale and well-designed observational studies are needed to investigate this topic further.
Validation of PROMIS Physical Function for Evaluating Outcome After Acute Achilles Tendon Rupture
Authors: Ochen Yassine , Guss Daniel , Houwert R. Marijn , Smith Jeremy T. , DiGiovanni Christopher W. , Groenwold Rolf H.H. , Heng Marilyn
Published: October 2021

Background:

There is increased demand for valid, reliable, and responsive patient-reported outcome measures (PROMs) to evaluate treatment for Achilles tendon rupture, but not all PROMs currently in use are reliable and responsive for this condition.

Purpose:

To evaluate the measurement properties of the Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS PF) compared with other PROMs used after treatment for acute Achilles tendon rupture.

Study Design:

Cohort study (diagnosis); Level of evidence, 2.

Methods:

A retrospective cohort study with a follow-up questionnaire was performed. All adult patients with an acute Achilles tendon rupture between June 2016 and June 2018 with a minimum 12-month follow-up were eligible for inclusion. Functional outcome was assessed using the PROMIS PF computerized adaptive test (CAT), Foot and Ankle Ability Measure (FAAM) Activities of Daily Living (ADL), FAAM–Sports, and Achilles Tendon Total Rupture Score (ATRS). Pearson correlation ( r) was used to assess the correlations between PROMs. Absolute and relative floor and ceiling effects were calculated.

Results:

In total, 103 patients were included (mean age, 44.7 years; 74% male); 82 patients (79.6%) underwent operative repair, while 21 patients (20.4%) underwent nonoperative management. The mean time between treatment and collection of PROMs was 25.3 months (range, 15-36 months). The mean scores were 55.4 ± 9.2 (PROMIS PF), 92.9 ± 12.2 (FAAM-ADL), 77.7 ± 22.9 (FAAM–Sports), and 83.0 ± 19.4 (ATRS). The ATRS was correlated with FAAM-ADL ( r = 0.80; 95% CI, 0.72-0.86; P < .001) and FAAM–Sports ( r = 0.86; 95% CI, 0.80-0.90; P < .001). The PROMIS PF was correlated with the FAAM-ADL ( r = 0.66; 95% CI, 0.53-0.75; P < .001), FAAM–Sports ( r = 0.65; 95% CI, 0.53-0.75; P < .001), and ATRS ( r = 0.69; 95% CI, 0.58-0.78; P < .001). The PROMIS PF did not show absolute floor or ceiling effects (0%). The FAAM-ADL (35.9%), FAAM–Sports (15.8%), and ATRS (20.4%) had substantial absolute ceiling effects.

Conclusion:

The PROMIS PF, FAAM-ADL, and FAAM–Sports all showed a moderate to high mutual correlation with the ATRS. Only the PROMIS PF avoided substantial floor and ceiling effects. The results suggest that the PROMIS PF CAT is a valid, reliable, and perhaps the most responsive tool to evaluate patient outcomes after treatment for an Achilles tendon rupture.
Framing Benefits in Decision Aids: Effects of Varying Contextualizing Statements on Decisions About Sacubitril-Valsartan for Heart Failure
Authors: Thomson Mary C. , Allen Larry A. , Halpern Scott D. , Ko Yi-An , Matlock Daniel D. , Mitchell Andrea R. , Moore Miranda A. , Morris Alanna A. , Rao Birju R. , Scherer Laura D. , Speight Candace D. , Ubel Peter A. , Dickert Neal W.
Published: October 2021

Background. Presenting numeric data alone may result in patients underappreciating clinically significant benefits. Contextualizing statements to counter this may raise concern about absence of neutrality. These issues arose during construction of a decision aid for sacubitril-valsartan, a heart failure medication associated with a ∼3% absolute reduction in 2-year mortality that carries high out-of-pocket cost. A contextualizing statement framing this as a “pretty big benefit” was incorporated. The impact of statements like this within decision aids is unknown. Objective. This online Qualtrics survey sought to deepen understanding of benefit framing by testing the impact of varying contextualizing statements within a decision aid for sacubitril-valsartan. Design. Participants were randomly assigned to receive one of six abbreviated versions of a decision aid for sacubitril-valsartan that varied only by contextualizing statement (ranging from strongly neutral to strongly positive and using relative and absolute risk reductions). Participants were asked to answer questions regarding the likelihood of taking the medication at a cost of $50/month and their perception of the drug’s benefits. Results. A total of 1873 participants who were demographically similar to the heart failure population completed the survey. Fifty-four percent were willing to take sacubitril-valsartan at $50/month. Each of the five experimental contextualizing statements was compared with the baseline version; no significant differences were observed in reported likelihood of taking sacubitril-valsartan. After controlling for demographics and covariates, group assignment did not predict likelihood of taking the medication. Higher income, better self-reported health status, and younger age were associated with increased likelihood of taking sacubitril-valsartan. Limitations. This study used a hypothetical scenario and evaluated one method of delivering contextualizing statements. Conclusions. Contextualizing statements as tested within this decision aid did not affect decision making.
Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway
Authors: Zeng Jie , He Si-Li , Li Li-Jie , Wang Chen
Published: October 2021

Background

HPV16 is the predominant cancer-causing strain that is responsible for over 50% of all cervical cancers. In this study, we aim to investigate the therapeutic effect of heat shock protein 90 (Hsp90) knockdown on HPV16+cervical cancer progression and the underlying mechanism.

Methods

The transcript and protein expression of Hsp90 in normal cervical and HPV16+cervical cancer tissues and cell lines were detected by qRT-PCR, immunohistochemistry staining and Western blot. Hsp90 knockdown clones were established using HPV16+cervical cancer cell line Caski and SiHa cells. The effect of Hsp90 knockdown on HER2/PI3K/AKT pathway and PD-L1 expression was characterized using qRT-PCR and Western blot analysis. Cell proliferation and migration were determined using MTT and transwell assays. Using mouse xenograft tumor model, the impact of Hsp90 knockdown and PD-L1 overexpression on tumor progression was evaluated.

Results

Hsp90 expression was up-regulated in HPV16+cervical cancer tissues and cells. Knockdown of Hsp90 inhibited proliferation and migration of Caski and SiHa cells. PD-L1 expression in cervical cancer tissues was positively correlated with Hsp90 expression, and Hsp90 regulated PD-L1 expression via HER2/PI3K/AKT signaling pathway. The results of mouse xenograft tumor model demonstrated Hsp90 knockdown suppressed tumor formation and overexpression of PD-L1 simultaneously eliminated the cancer-suppressive effect of Hsp90 knockdown.

Conclusion

In this study, we demonstrated a promising tumor-suppressive effect of Hsp90 knockdown in HPV16+cervical cancers, and investigated the underlying molecular pathway. Our results suggested that Hsp90 knockdown holds great therapeutic potential in treating HPV16+cervical cancers.
Conserved and breed-specific differences in the cervical transcriptome of sheep with divergent fertility at the follicular phase of a natural oestrus cycle
Authors: Abril-Parreño Laura , Meade Kieran G. , Krogenæs Anette Kristine , Druart Xavier , Fair Sean , Cormican Paul
Published: October 2021

Background

The outcome of cervical artificial insemination (AI) with frozen-thawed semen in sheep is limited by the inability of sperm to traverse the cervix of some ewe breeds. Previous research has demonstrated that cervical sperm transport is dependent on ewe breed, as sperm can traverse the cervix in greater numbers in some higher fertility ewe breeds. However, the molecular mechanisms underlying ewe breed differences in sperm transport through the cervix remain unknown. In this study, we aimed to characterise the cervical transcriptome of four European ewe breeds with known differences in pregnancy rates following cervical AI using frozen-thawed semen at the follicular phase of a natural oestrous cycle. Cervical post mortem tissue samples were collected from two Irish ewe breeds (Belclare and Suffolk; medium and low fertility, respectively) and from two Norwegian ewe breeds (Norwegian White Sheep (NWS) and Fur; high fertility compared to both Irish breeds) at the follicular phase of a natural oestrous cycle (n = 8 to 10 ewes per breed).

Results

High-quality RNA extracted from biopsies of the mid-region of the cervix was analysed by RNA-sequencing and Gene Ontology (GO). After stringent filtering (P <  0.05 and FC > 1.5), a total of 11, 1539 and 748 differentially expressed genes (DEGs) were identified in Belclare, Fur and NWS compared to the low fertility Suffolk breed, respectively. Gene ontology analysis identified significantly enriched biological processes involved in muscle contraction, extracellular matrix (ECM) development and the immune response. Gene co-expression analysis revealed similar patterns in muscle contraction and ECM development modules in both Norwegian ewe breeds, which differed to the Irish ewe breeds.

Conclusions

These breed-specific biological processes may account for impaired cervical sperm transport through the cervix in sheep during the follicular phase of the reproductive cycle. This novel and comprehensive dataset provides a rich foundation for future targeted initiatives to improve cervical AI in sheep.
Transcriptome analysis of Clavibacter michiganensis subsp. michiganensis-infected tomatoes: a role of salicylic acid in the host response
Authors: Yokotani Naoki , Hasegawa Yoshinori , Sato Masaru , Hirakawa Hideki , Kouzai Yusuke , Nishizawa Yoko , Yamamoto Eiji , Naito Yoshiki , Isobe Sachiko
Published: October 2021

Bacterial canker of tomato (Solanum lycopersicon) caused by the Gram-positive bacteriumClavibacter michiganensissubsp.michiganensis(Cmm) is an economically important disease.To understand the host defense response toCmminfection, transcriptome sequences in tomato cotyledons were analyzed by RNA-seq. Overall, 1788 and 540 genes were upregulated and downregulated upon infection, respectively. Gene Ontology enrichment analysis revealed that genes involved in the defense response, phosphorylation, and hormone signaling were over-represented by the infection. Induced expression of defense-associated genes suggested that the tomato response toCmmshowed similarities to common plant disease responses. After infection, many resistance gene analogs (RGAs) were transcriptionally upregulated, including the expressions of some receptor-like kinases (RLKs) involved in pattern-triggered immunity. The expressions ofWRKYs,NACs,HSFs, andCBP60sencoding transcription factors (TFs) reported to regulate defense-associated genes were induced after infection withCmm. Tomato genes orthologous to ArabidopsisEDS1,EDS5/SID1, andPAD4/EDS9, which are causal genes of salicylic acid (SA)-deficient mutants, were upregulated after infection withCmm. Furthermore,Cmminfection drastically stimulated SA accumulation in tomato cotyledons. Genes involved in the phenylalanine ammonia lyase pathway were upregulated, whereas metabolic enzyme gene expression in the isochorismate synthase pathway remained unchanged. Exogenously applied SA suppressed bacterial growth and induced the expression ofWRKYs, suggesting that someCmm-responsive genes are regulated by SA signaling, and SA signaling activation should improve tomato immunity againstCmm.
Predictive ability of the G8 screening test to determine probable sarcopenia and abnormal comprehensive geriatric assessment in older patients with solid malignancies
Authors: Cavusoglu Cagatay , Tahtaci Gozde , Dogrul Rana Tuna , Ileri Ibrahim , Yildirim Funda , Candemir Burcu , Kizilarslanoglu Muhammet Cemal , Uner Aytug , Goker Berna
Published: October 2021

Background

Pre-treatment evaluation for sarcopenia is recommended in cancer patients. New screening tests that are less time-consuming and can identify patients who will potentially benefit from geriatric assessment are being developed; the G8 geriatric screening test is one such example. We aimed to investigate whether the G8 screening test can detect probable sarcopenia and is valid and reliable compared to a comprehensive geriatric assessment (CGA) in Turkish older adults with solid cancers.

Methods

We included solid cancer patients referred to a single center. Probable sarcopenia and abnormal CGA were defined as low handgrip strength. Cut-offs for handgrip strength in the Turkish population have been previously determined to be 32 kg for males and 22 kg for females and impairment in at least one of the CGA tests, respectively. The CGA tests comprised KATZ Basic Activities of Daily Living Scale Lawton–Brody Instrumental Activities of Daily Living Scale, Mini-Mental-State Examination Scale, Geriatric Depression Scale-15, and Mini-Nutritional Assessment Short Form. Receiver operating characteristic curve analyses evaluated the test’s predictive ability. Intra-rater and inter-rater reliabilities were assessed.

Results

The median age of the 76 patients included was 72 (65–91) years. There was a moderate correlation between handgrip strength and the G8 test total score. The sensitivity and specificity of the G8 test to detect probable sarcopenia alone (cut off score = 12.5) were 50 and 92%, respectively (AUC: 0.747; p < 0.001); to determine abnormal CGA plus probable sarcopenia (cut off score = 13) were 93.33 and 86.89%, respectively (AUC: 0.939; p < 0.001); and to detect abnormal CGA alone (cut off score = 14) were 79.63 and 95.45%, respectively (AUC: 0.893; p < 0.001). The G8 test results agreed with those of CGA (κ = 0.638; p < 0.001). Both inter- and intra-rater assessments of G8 scores revealed a strong agreement (Interclass correlation coefficient = 0.979, p < 0.001 and ρ = 0.994, p < 0.001, respectively).

Conclusions

The Turkish version of the G8 test is a good screening tool to detect probable sarcopenia alone and in conjunction with abnormal CGA in older patients with solid malignancies. The G8 screening tool may thus be useful in detecting probable sarcopenia in Turkish older adults with solid cancers.
Mycobacteria avium-related peritonitis in a patient undergoing peritoneal dialysis: case report and review of the literature
Authors: Lu Jifang , Jiang Zhou , Wang Ling , Mou Shan , Yan Hao
Published: October 2021

Background

Mycobacteria avium (M. avium) is a species of ubiquitous slowly growing nontuberculous mycobacteria. It causes opportunistic infections. However, M. avium-related peritonitis in peritoneal dialysis (PD) patients is rare.

Case presentation

A 51-year-old female end-stage kidney disease patient undergoing PD was admitted for a noninfectious complication. She presented catheter exit site drainage and slightly increased PD effluent white cell count (WCC) with polymorphonuclear predominance on admission. Exit site infection and PD-related peritonitis were diagnosed. Repeated cultures of effluent and drainage were negative. Initial empirical antibiotics and further adjustment were not rewarding. PD was terminated 2 weeks later, however, shortly the patient developed stupor, high fever, peritoneal irritation, and spontaneous chylous ascites, and showed elevated ascitic adenosine deaminase (ADA). The manifestations persisted and the patient’s general condition deteriorated despite intensified antibiotic therapy. Massive parallel sequencing identified M. avium in ascites on hospital day 25, and 4-drug treatment with azithromycin, amikacin, rifampin, and ethambutol was initiated. Nevertheless, the patient died from sepsis on hospital day 30.

Conclusions

We report a case of PD-related M. avium peritonitis. Prolonged culture-negative peritonitis, chylous ascites, and elevated ascitic ADA may hint the possibility of mycobacterial infections. Diagnostic method allowing prompt identification of the pathogen is warranted. The prognosis can be extremely poor, and the prophylaxis and treatment should be better defined.
Recurrent primary pyogenic ventriculitis in an adult woman: a case report
Authors: Hong Shanyan , Yang Yingxia , Zhang Qianying , Zhuo Shitu , Wang Lingxing
Published: October 2021

Background

Recurrent primary pyogenic ventriculitis has not been reported previously. We present a unique case of recurrent primary pyogenic ventriculitis in an adult. And we believe that our study makes a significant contribution to the literature.

Case presentation

An adult woman with uncontrolled diabetes experienced two episodes of pyogenic ventriculitis caused by Escherichia coli over 4 years. She had typical imaging features, and the source of infection was undetermined. After antibiotic treatment, she recovered fully.

Conclusions

Early recognition and therapy will improve patient prognosis.
Retrospective comparison of death or neurodevelopmental outcomes in extremely low birth weight preterm infants following different management options of haemodynamically significant patent ductus arteriosus
Authors: Wu Jania Jia-Ying , Niduvaje Krishnamoorthy , Lee Le ye , Amin Zubair
Published: October 2021

Background

Optimal management of haemodynamically significant patent ductus arteriosus (HsPDA) in premature babies remains controversial. Our aim is to compare death and/or adverse neurodevelopmental outcomes in extremely low birth weight (ELBW) infants with HsPDA who were managed with conservative [C], medical [M] and/or surgical [S] treatment, with secondary aim to examine short-term morbidities among [S] and [C] groups. The study also compared outcomes in very low birth weight (VLBW) infants with HsPDA and non-HsPDA.

Methods

A retrospective study of VLBW preterm infants born before 29 weeks in Singapore from 2007 to 2016 was conducted.

Results

A total of 474 VLBW infants were admitted in NUH from 2007 to 2016. Infants aged between 24 + 0 and 28 + 6 weeks of gestation, weighing ≤1500 g and diagnosed with patent ductus arteriosus (PDA) were included in the study, of which 172 infants (124 HsPDA and 48 non-HsPDA) were analyzed. Among infants with HsPDA, 17 infants were managed with [C], 83 with [M] and 24 with [S]. Mortality was not increased regardless of the presence of HsPDA or treatment received. Infants with non-HsPDA were less likely to have isolated speech delay (p < 0.05), but not global developmental delay (GDD). No significant differences in neurodevelopmental outcomes such as hearing loss, cerebral palsy (CP) and speech delay were found. [M + S] infants were at a higher risk of developing chronic lung disease (CLD) (OR 6.83, p < 0.05) and short-term growth failure compared to [C] infants. They were significantly shorter and had a smaller head circumference at discharge (p < 0.05). [M + S] infants also had elevated creatinine compared to those in group [C] (81.1 ± 24.1 vs 48.3 ± 11.8 umol/L, p < 0.000).

Conclusions

Compared to conservative management, infants requiring [M + S] treatment for HsPDA were more likely to have short-term complications such as CLD, elevated creatinine, and poorer growth. Despite a more turbulent postnatal course, death and/or adverse neurodevelopmental outcomes were not worse in infants managed with [M + S].
Time-varying effect of drunk driving regulations on road traffic mortality in Guangzhou, China: an interrupted time-series analysis
Authors: Xu Xiao-Han , Dong Hang , Li Li , Yang Zhou , Lin Guo-Zhen , Ou Chun-Quan
Published: October 2021

Background

China has introduced a series of stricter policies to criminalize drunk driving and increase penalties since May 2011. However, there is no previous study examining the time-varying impacts of drunk driving regulations on road traffic fatalities based on daily data.

Methods

We collected 6536 individual data of road traffic deaths (RTDs) in Guangzhou from 2008 to 2018. The quasi-Poisson regression models with an inclusion of the intervention variable and the interaction of intervention variable and a function of time were used to quantify the time-varying effects of these regulations.

Results

During the 11-year study period, the number of population and motor vehicles showed a steady upward trend. However, the population- and motor vehicles- standardized RTDs rose steadily before May 2011, the criminalizing drunk driving intervention was implemented and gradually declined after that. The new drunk driving intervention were associated with an average risk reduction of RTDs (ER = -9.01, 95% eCI: − 10.05% to − 7.62%) during the 7.7 years after May 2011. On average, 75.82 (95% eCI, 54.06 to 92.04) RTDs per 1 million population annually were prevented due to the drunk driving intervention.

Conclusion

These findings would provide important implications for the development of integrated intervention measures in China and other countries attempting to reduce traffic fatalities by stricter regulations on drunk driving.