bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Kecerdasan Emosional dan Kepemimpinan Transformasional Terhadap Kinerja Karyawan yang Dimediasi oleh Kepuasan Kerja Pada PT. Transco Energi Utama Kabupaten Pesisir Selatan
Authors: Ridwan Muhammad , Games Donard , Lukito Hendra
Published: October 2024

Penelitian ini bertujuan untuk menganalisis pengaruh langsung Kecerdasan Emosional dan Kepemimpinan Transformational terhadap kinerja melalui kepuasan kerja karyawan, serta pengaruh kepuasan kerja terhadap kinerja karyawan di PT. Transco Energi Utama. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei, melibatkan 110 responden yang dipilih melalui teknik probability sampling. Instrumen penelitian diuji dengan SPSS, dan data dianalisis menggunakan SEM dengan software SmartPLS versi 3.5.0, penelitian ini menemukan bahwa Emotional Intelligence tidak memiliki pengaruh signifikan terhadap kepuasan kerja dan kinerja karyawan. Sebaliknya, Transformational Leadership memiliki pengaruh positif dan signifikan terhadap keduanya. Kepuasan kerja juga berpengaruh positif dan signifikan terhadap kinerja karyawan. Namun, kepuasan kerja tidak memediasi pengaruh Emotional Intelligence terhadap kinerja, tetapi secara signifikan memediasi pengaruh Transformational Leadership terhadap kinerja karyawan.
Development and Assessment of Herbal Sanitizer Derived from Plant Extract
Authors: K.C Sagar , Paudel Krishma , Paudel Prajol , Khadka Navaraj , Khadka Sanjeet , Ranjitkar Hasina , Pantha Amrita , Paudyal Anjila , K.C Swyika , Shrestha Samira , Satshankar Sunita , Kharel Surakshya , Sah Monika , Manandhar Praj , Karki Sampurna , Chaudhary Mandal Priyanka Kumari , Dahal Bijaya , Gautam Sunil
Published: October 2024

Introduction: A key component in the prevention, management, and decline of healthcare-acquired illnesses is hand sanitizer. Multi-drug-resistant infections are among the persistent issues related to infections acquired while receiving medical care. Maintaining good hand hygiene can greatly lower the chance of cross-contamination. In recent times, hand sanitization has been increasingly popular as a means of reducing nosocomial infections that a variety of opportunistic bacteria can cause.  Method: Using a methanol solvent and a maceration method, the extract was obtained from the leaves of the neem and tulsi plants. The disc diffusion technique was used to determine and assess the antibacterial activity by measuring the diameter of the zone of inhibition. It was decided to create a herbal hand sanitizer.  Results: According to the study, both Ocimum sanctum and Azadirachta indica include terpenoids, alkaloids, glycosides, tannins, and saponins. All of the studied microorganisms displayed a zone of inhibition in the solvent extract within the 5-23 mm range. It was discovered that the extracts' antibacterial efficacy depended on concentration.  Conclusion: As a platform for further research and the creation of novel therapeutic entities, the study's findings indicate the presence of various phytochemical elements with antibacterial capabilities. We may infer that the stated organisms (S. aureus, K. pneumoniae, P. aeruginosa, & E. coli) are much less susceptible to bacterial growth when exposed to herbal sanitizer. Based on many anti-bacterial tests, it has been shown that the high-concentration formulation (40 mg/ml) is highly efficient in treating bacterial disorders.
Analysing the Capital Structure of Indian Entertainment and Pharmaceutical Industry: A Comparative Study
Authors: Sajjan Aishwarya
Published: October 2024

This research work has been done through the various analysis regarding the capital structure of different industries. The work has been done to know the different capital structure mix of Entertainment and Pharmaceutical industry of India. Where to know the Capital structure impact on the profitability of different companies along with Covid 19 period. I also had been used the statistical analysis for comparison of both the industries which is R Software programme. The panel data models had been analysed in this research with Fixed effect method of Least squared Dummy Variable [LSDV] model.
Revolutionizing Pharmacy Benefit Management: Cost-Reduction through Artificial Intelligence and Data Analytics in Healthcare
Authors: Kumar Chinnathambi Jinesh
Published: October 2024

Pharmacy Benefit Managers (PBMs) are third party companies that function as intermediaries between insurance providers and pharmaceutical manufacturers. PBMs create formularies, negotiate rebates (discounts paid by a drug manufacturer to a PBM) with manufacturers, process claims, create pharmacy networks, review drug utilization, and occasionally manage mail-order specialty pharmacies. [1] Pharmacy benefit management (PBM) is important for keeping prescription drug costs under control. But the problem is that drug prices keep going up, which makes things tough for the healthcare industry. In this article, we look at how fancy technology like artificial intelligence (AI) and data analysis can help PBM find new ways to save money. By using advanced technology to study a large amount of information, PBMs can find patterns and make educated guesses about how to best use medications. Artificial intelligence makes this even more advanced by helping to quickly find and stop fraud, personalize medication plans, and predict costs more accurately. Remember this: AI and data analytics are being used to make pharmacy benefit programs work better. This helps save money and makes things better for patients. We look at how machine learning models can predict patient adherence, how natural language processing (NLP) can improve medication reviews, and how blockchain technology can keep supply chains transparent and secure. Real-world examples show how these technologies are already making a difference, such as cutting down on administrative work, reducing drug waste, and getting the most out of drug utilization. As more healthcare systems start using these advanced tools, it’s becoming clear that continual innovation and the inclusion of AI and data-driven methods are essential. This article highlights the importance of staying updated with the ever-changing ways of controlling prescription drug expenses by using new technology. For pharmacy benefit managers (PBMs) focused on offering the best value and working effectively despite increasing healthcare costs, adopting these advancements is not just a good choice, it's necessary.
The Historiography of Forests use Types and Implication for Forest Conservation in the Montane Forests of Ngongbaa, Kilum, Kovifem and Kovkinkar
Authors: Louis Banadzem Tatah Jean-
Published: October 2024

This study explores the timeline history of forest use types and beneficial relationship of forest, forest communities and conservation in the montane forests of Ngongbaa, Kilum, Kovifem and Kovkinkar from the mid-1970s to 2015. Data and/or information collected for this study comprise literary, questionnaire, interview, focused group discussions and observations. Data for the study was secured from person directly resident adjacent forest in 29 villages. The study shows that apart from being asource of food and medicine, forest first served as settlement and refuge sites for the Nso, Mbiame and Oku people. Today, forest serves as cemetery for the fons (kings), and host shrines which have become conservation hot spots and nurseries for engendered plants and animal species, where the Nso, Mbiame and Oku also performed sacrifices. These conservation hot spots help to sustain the forest in montane ecosystems where pressure on land and forest is high and on the rise. Due to population pressure and limited grazing the grassland compartments in the above forests have been transformed into grazing ground. The long period of intercourse between the Nso, Mbiame, Oku people and their forest enabled them to accumulate rich and useful knowledge of the forest and established customary (non- statutory or quasi-statutory) regulatory frameworks for effective management of forest resources to improve their livelihood and culture. Due to the depletion of forest and the adoption of stricter conservation policies, some forest activities particularly carving and hunting have decreased in intensity while some like Ngwa’a (royal hunt) has simply phased out due to the extinction of animal species which were hunted. The paper recommends that traditional systems of managing forest be reinforced to enhance the conservation of resources in sacred groves that are nurseries for threatened and extinct species in degraded ecosystems. The state should recognise and integrate non-statutory forestry policy frameworks established in the Nso, Mbiame and Oku into the national forestry policy as village-based institutions for the management of land and forest in forest communities. The government should also empower traditional authorities (Fon,Nwerong and Lanlords (ataangven) and support reforestation and forest restoration programmes formulated by them. This is because laws put in place by these institutions are respected in the most part by their subjects without being forced to do so, unlike in the Ngongbaa and Kilum forests managed by the state, where forestry laws are permanently violated by local people who consider forestry authorities as state agents who are depriving them of their right of tenure and usufruct. This would likely help to maintain biodiversity and knowledge attached to it, which is gradually disappearing due to forest depletion.
Effect Of Cerclage Suture Type On Pregnancy And Newborn Results: Mersylene Suture Versus Prolene Suture
Authors: Kayapınar Masum , Bütün Zafer , Savaş Melike
Published: October 2024

Purpose: The aim of this study is to compare pregnancy and neonatal outcomes according to the type of the suture material used in the transvaginal cerclage operation.
Materials and Methods: Patients who underwent transvaginal cervical cerclage due to cervical insufficiency in a tertiary health center between 2020 and 2024 were evaluated retrospectively. Demographic data regarding cerclage indications (ultrasound-based, prophylactic or physical examination-based), number of weeks of gestation in cerclage, cerclage suture type (prolene, mersilen), gestational week at cerclage insertion and delivery, routes of delivery were recorded. In addition, birth weight, 1st and 5th minute APGAR scores, and neonatal intensive care unit (NICU) requirements were recorded as neonatal parameters. Patients were divided into two groups according to cerclage suture type (mersilene or prolene) and maternal, newborn and pregnancy outcomes were compared between these groups.
Results: Comparison of the groups in terms of age, gravidity, parity, number of miscarriages and BMI revealed significantly higher mean gravidity in group 1 compared to group 2 (P0.05). No difference was determined with regard to gestational week at cerclage application, cervical length, cervical dilatation just before cerclage insertion, gestational age at cerclage removal and delivery and birth weight (p>0.05). Groups were comparable in terms of subgroups established according to their numbr number of previous deliveries (p>0.05). Groups were comparable in terms of indications for cerclage insertion (p>0.05). Cesarean delivery rate was 40 % in group 1 while it was 43.6 % in groups 2, no statistical difference was determined in terms of rate of cesarean delivery (p>0.05). Similar number of newborns needed NICU admission between the two groups following delivery (17.5% versus 17.9 %p>0.05). Mean APGAR scores at 1st (6.8 versus 7.4) and 5 th (7.8 versus 8.3) min were comparable between the groups (p>0.05)
Conclusion: Although mersilen stitch is commonly preferred, data analysis revealed similar results with prolene stitch in terms of maternal and neonatal outcomes.
Elliptic curves cryptography for lightweight devices in IoT system
Authors: Fadia Taleb , Toufik Larid
Published: October 2024

The Internet of Things (IoT) is revolutionizing industries by connecting billions of devices, ranging from home appliances to industrial machines, to the internet. This transformation enables unprecedented automation, data collection, and process optimization. However, the widespread adoption of IoT also introduces significant security challenges, especially for lightweight devices with limited computational power and energy resources. Ensuring secure communication and data integrity in such constrained environments is critical. This paper explores and compares the performance of implemented algorithms within IoT devices. A comparison between Rivest-Shamir-Adleman (RSA) and Elliptic Curve Cryptography (ECC) implementations is made to identify a lightweight, secure, and efficient solution for IoT environments. Our results indicate that ECC outperforms RSA in terms of memory requirements, overall energy consumption, key sizes, signature generation time, key generation and execution time, and decryption time in a resource-constrained environment. However, RSA performs better in signature verification and encryption.
rol de la OEA en el combate a la corrupción en Honduras
Authors: Bonilla Cabañas Jimena
Published: October 2024

La corrupción en Honduras alcanzó niveles alarmantes, sumado al clima de violencia e inseguridad que a diario azota al país, siendo el millonario desfalco del Instituto Hondureño de Seguridad Social (IHSS) el detonante para que la sociedad hondureña se manifestara en las calles de las principales ciudades del país, exigiendo justicia y un alto a la corrupción e impunidad imperante. Los hondureños se aglutinaron a nivel nacional e internacional en el movimiento denominado “Los Indignados”, quienes a partir del mes de abril del año 2015 hasta el mes de septiembre de ese mismo año, se mantuvieron constantemente durante todos los viernes de cada semana en protestas pacíficas. Ante las exigencias de la sociedad, el Gobierno de Honduras, se vio en la necesidad de instar a un diálogo nacional, con la participación de actores claves de la sociedad civil y representantes de organizaciones internacionales. Teniendo como resultado la instalación de la Misión de Apoyo Contra la Corrupción e Impunidad (MACCIH), en el mes de enero del año 2016, mediante la suscripción del Convenio celebrado entre la Organización de Estados Americanos (OEA) y el Gobierno de la República de Honduras, cuyo objetivo ha sido brindar cooperación en el fortalecimiento del sistema de justicia y seguridad en el país.
jurisprudencia y doctrina europea en las sentencias del Tribunal de Justicia de la Comunidad Andina
Authors: Reyes Tagle Renato
Published: October 2024

Este trabajo tiene como objetivo analizar el nivel de interrelación que existe entre el derecho comunitario europeo y el andino, a partir del trabajo jurisprudencial que han desarrollado el Tribunal de Justicia de la Unión Europea (TJUE) y el Tribunal de Justicia de la Comunidad Andina de Naciones (TJCA) en sus respectivas jurisdicciones. Con tal objetivo, se examina la contribución de la doctrina europea en la elaboración de sentencias del Tribunal de Justicia de la Comunidad Andina, referidas a la interpretación del derecho comunitario. Asimismo, el presente estudio hace una revisión de algunos de los casos y sentencias del TJCA en los que se han encontrado referencias al TJUE. De la misma manera, realiza un examen comparativo sobre la interpretación que ambos Tribunales han entendido respecto al principio de aplicación directa del ordenamiento jurídico comunitario.
50° Aniversario de la Convención de Viena sobre el Derecho de los Tratados de 1969
Authors: Talavera Espinar Manuel
Published: October 2024

Hoy nos encontramos reunidos para conmemorar un hecho que ocurrió en la ciudad de Viena, República de Austria, el 23 de mayo de 1969, cuando se abrió a la firma la Convención, luego que su texto fuera adoptado el día anterior por más de un centenar de Estados, incluyendo al Perú. Recordemos que, a mediados del siglo XX, luego de haber sufrido dos guerras mundiales, los Estados se dieron cuenta de la imperiosa necesidad de contar con una Organización para velar por la Paz y la seguridad internacional, y es por ello, que el 24 de octubre de 1945, al entrar en vigor la Carta de las Naciones Unidas, se creó dicha organización internacional.
Entre la utopía y la distopía: Crisis de los paradigmas de la globalización
Authors: Chuquihuara Chil Luis
Published: October 2024

El presente artículo aborda los actuales cuestionamientos a los paradigmas fundacionales de la globalización en tres aspectos: político, económico y social. En el ámbito político, la democracia liberal se enfrenta al surgimiento de populismos de antagónico signo ideológico y al incremento de la tensión internacional que interfiere en la cooperación entre Estados. En el campo económico, la economía de mercado y el libre comercio hacen frente al renacimiento del proteccionismo y al auge del escepticismo frente a los procesos regionales como subregionales de integración. En el horizonte social, los derechos humanos y ciudadanos son desafiados por el dogmatismo, el fundamentalismo, la xenofobia y la discriminación de diverso origen. Todo ello indica que nos encontramos en un momento decisivo para las Relaciones Internacionales contemporáneas.
Distribution of vectors and arboviruses, and healthcare workers’ knowledge of vector-borne diseases in Armenia
Authors: Babayan Lilit , Manucharyan Arsen , Paronyan Lusine , Vardanyan Haykuhi , Danielyan Ruben , Melik-Andreasyan Gayane , Achenbach Jenna E
Published: October 2024

Introduction: Armenia’s favorable geographical and climatic conditions support mosquitoes, sandflies, and ticks that can transmit various diseases. This study aimed to determine the prevalence of these vectors and circulating arboviruses in Armenia and assess healthcare workers` knowledge of arboviral diseases.
Methodology: In 2021, we conducted fieldwork, combining morphological identification of vectors with polymerase chain reaction (PCR) analysis of pathogens to map the distribution of potential arbovirus vectors across Armenia.
Results: Our entomological surveys identified four mosquito genera—Anopheles, Aedes, Culex, and Culiseta—comprising 20 species; and 11 species of Ixodidae ticks. Culex pipiens was found in all 11 regions, while Culiseta spp. was absent in Ararat Province. PCR testing of mosquito and tick samples revealed Crimean-Congo hemorrhagic fever virus (CCHFV) in 13 tick samples, but West Nile virus (WNV) was not detected in mosquitoes. Specifically, 13 out of 525 Ixodes tick pools tested positive for CCHFV; the positive samples originated from Hyalomma marginatum ticks in Syunik’s Sisian region. None of the 11 pools that contained 473 Cx. pipiens mosquitoes tested positive for WNV. Analysis of questionnaires from 499 healthcare workers showed that epidemiologists, infectious disease specialists, and family doctors had greater awareness of arboviral diseases than other specialists. However, there was a low rate of sample submission for laboratory diagnosis and confirmation.
Conclusions: The extensive presence of vectors combined with limited knowledge of arboviral diseases complicates disease understanding in Armenia. Strengthening the surveillance system through training and improved sample collection is essential for disease monitoring and public health interventions.
The first case of Mpox infection in Iran during the 2022 outbreak
Authors: Maleki Ali , Arashkia Arash , Pouriayevali Mohammad Hassan , Jalali Tahmineh , Tavakoli Mahsa , Modoodi Yaghooti Mohammad , Ahmadi Zahra , Niknam Oskouei Farideh , Fereydouni Zahra , Azadmanesh Kayhan , Salehi‐Vaziri Mostafa , Rohani Mahdi
Published: October 2024

Introduction: The unexpected outbreak of human Mpox infection beginning in some European countries that were non-endemic for Mpox stunned the world during the Coronavirus Disease 2019 (COVID-19) pandemic in May 2022. The re-emerging Mpox outbreak, which has a greater capacity for human-to-human transmission, was mainly due to traveling. In this paper, we describe the first case of the disease was observed in an Iranian woman infected by her husband who had a history of traveling to Canada.
Case Report: The 34-year-old woman had flu-like syndrome with some skin rashes on her hand, finger, and arm. No antivirals were prescribed in this case, and supportive care was used to help her recover. RT-PCR and Sanger sequencing were used to analyze the sample from the oropharyngeal swab and the rash, and the results confirmed the Mpox infection.
Conclusions: The risk of infectious disease outbreaks after COVID-19, such as Mpox, is of great importance, and health systems should be vigilant for timely identification and preparedness.
Incidence and severity of pertussis among hospitalized infants, Sarawak, Malaysia, 2015-2021
Authors: Mohan Anand , Tan Yee-Yen , Hashim Rohaidah , Ng David Chun-Ern , Wong Veronica Huey-Shin , Liew Da-Wei , Chien Su-Lin , Tan Lee-See , Lau Peter Sie-Teck , Rajandran Thilagam , Podin Yuwana , Ooi Mong-How
Published: October 2024

Introduction: A resurgence of pertussis has been reported in numerous countries. This study aimed to determine the incidence, clinical characteristics, and outcome of pertussis among infants in Sarawak, Malaysia.
Methodology: We conducted a descriptive retrospective study of infants aged < 12 months with laboratory-confirmed pertussis admitted to Bintulu Hospital in Sarawak, Malaysian Borneo, from 2015 until 2021. Pertussis was confirmed in all patients using a polymerase chain reaction of nasopharyngeal aspirates.
Results: Of 588 infants who had a nasopharyngeal aspirate, 108 (18%) had laboratory-confirmed pertussis. The average annual incidence was 482 per 100,000 infants aged < 12 months between 2015 and 2019, with a marked decline in 2020 and 2021. Eighty-two (76%) were < 3 months of age. Seventy-eight (72%) were unvaccinated for pertussis, including 75 (96%) who were too young to receive the first dose. A third of the cases had atypical presentations. Severe disease characterized by hypoxemia, pulmonary hypertension, recurrent apnea, encephalopathy, or cardiovascular dysfunction occurred in 32%. Forty-eight percent required humidified high-flow nasal cannula oxygen therapy and 22% required invasive ventilation. Twenty-four percent overall needed intensive care. One (1%) infant had a fatal outcome. Nearly all cases of severe disease or those that required invasive ventilation or intensive care had received ≤ 1 dose of pertussis vaccination.
Conclusions: A high incidence of pertussis with a high rate of severe disease was observed in Sarawak, Malaysia, predominantly among infants too young to be vaccinated. Additional vaccination strategies such as maternal vaccination or cocooning should be considered.
The fear of COVID-19, health literacy and levels of compliance with prevention measures of adult individuals in Turkey
Authors: Yiğitalp Gülhan
Published: October 2024

Introduction: It is known that health literacy and fear of COVID-19 are effective in complying with COVID-19 prevention measures. A limited number of studies have shown the relationship between health literacy, fear of COVID-19, and compliance with COVID-19 prevention measures. The purpose of this study is to investigate the fear of COVID-19, health literacy, compliance levels with prevention measures of adult individuals and influential factors.
Methodology: The cross-sectional study used an online questionnaire and was conducted with 1018 adults aged 18-64 in Turkey between 01-31 December 2020. The convenience sampling method was used to determine the sample. Student t-test, ANOVA, correlation, and multiple linear regression were used.
Results: Half of the participants (49.9%) had inadequate and problematic-limited health literacy (HL). Adults` compliance with measures during the COVID-19 pandemic and some sociodemographic characteristics had a significant relationship with HL and fear of COVID-19 (p < 0.05). It was determined that those with high HL and those afraid of COVID-19 paid more attention to precautions (p < 0.05). Health literacy was a predictor of fear of COVID-19 (β = -0.091; p < 0.001).
Conclusions: Governments need to invest in increasing health literacy.
Quelques réflexions sur la question des archives/de l’archive
Authors: Corre Hervé Le
Published: October 2024

Cette lecture réalisée à partir du livre de Jacques Derrida, Mal d’archive. Une impression freudienne (1995) comporte deux moments. Le premier consiste en une tentative de lecture du texte derridien et des enjeux qu’il implique pour penser la notion d’archive, depuis des horizons politiques, heuristiques et psychanalytiques, entre autres. Le second moment consiste en une reprise de quelques-uns des apports derridiens, auxquels s’ajoutent, de façon plus ponctuelle, d’autres contributions (Foucault, Jablonka, Ricœur…) dans la perspective qui était la nôtre à l’heure d’inaugurer une réflexion commune sur l’archive, à savoir penser l’archive depuis un lieu (l’Amérique hispanique depuis le xixe siècle) et à l’intersection entre écriture fictionnelle et historiographie.
El escritor en exilio y su archivo. Configuración de una trayectoria intelectual
Authors: Espinosa María Carrillo
Published: October 2024

La poética del exilio llama la atención sobre la no permanencia o la finitud de las coordenadas espaciotemporales. Su constitución, nostálgica por excelencia, se vuelca en la imagen del centro móvil como único lugar de pertenencia posible. Parece que aquí un concepto como el de archivo, con sus implicaciones de materialidad, domiciliación, autoridad e institucionalización, no tiene cabida. Sin embargo, los escritores en el exilio dejan de manifiesto la necesidad de crear su archivo personal con la esperanza de que en un futuro éste pueda ser transmitido al público deseado. Tal es el caso de los tres autores del exilio español republicano que mencionaremos en este estudio –María Zambrano, Max Aub y Angelina Muñiz-Huberman– cuyos textos son escritos, reunidos y, algunos de ellos, conservados en Hispanoamérica. La finalidad de esta reflexión será dilucidar las particularidades de un archivo configurado en el contexto particular del exilio: notablemente su relación poco sólida con las instituciones culturales, así como su preparación en solitario, esto es, sin noción de exterioridad, ni de receptores inmediatos.
Experiencias de creación de archivos en la investigación de la historia reciente
Authors: Puente Maximiliano De La
Published: October 2024

En esta presentación nos referiremos a la generación de dos archivos audiovisuales en el marco de sendos proyectos de investigación que tienen lugar en Argentina: uno con sede en el Instituto de Investigaciones Gino Germani, perteneciente a la Facultad de Ciencias Sociales de la Universidad de Buenos Aires, y otro con sede en el Instituto de Cultura, Sociedad y Estado de la Universidad Nacional de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Se trata de dos experiencias opuestas, pero con puntos en común. En el primer caso abordamos un archivo que se encuentra ubicado en uno de los principales centros de investigación en ciencias sociales y humanidades, emplazado en la ciudad más importante del país en cuanto a recursos económicos, sociales y culturales. Se trata del «Fondo Documental Teatro y Política en América Latina» (TyPAL) que forma parte del Proyecto de Investigación Científica y Tecnológica (PICT): «Dialécticas de incidencia entre las artes escénicas y la trama política (1976-2017)». Tiene una duración de tres años (2018-2021) y es financiado por la Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Agencia I+D+I), perteneciente al Ministerio de Ciencia, Tecnología e Innovación de Argentina. En el segundo caso, reflexionamos a partir de la constitución de un archivo audiovisual ubicado en la provincia más joven y remota del país, que se encuentra a tan solo mil kilómetros de distancia de la Antártida. Finalmente, concluiremos haciendo un diagnóstico del precario estado de los archivos audiovisuales en Argentina.
La prévention intégrée au travail : une conceptualisation basée sur les perspectives des parties prenantes canadiennes
Authors: Bellehumeur-Béchamp Lily , Drolet Andrée-Anne , Major Marie-Ève , Lederer Valérie , Vincent Claude , Lecours Alexandra
Published: October 2024

Introduction. La prévention intégrée au travail est un concept qui gagne en popularité, mais la quantité limitée d’écrits sur le sujet rend sa définition incomplète. La perspective de personnes y étant exposées pourrait contribuer à l’élaboration d’une définition bonifiée. Objectif. Cette étude visait à raffiner la définition de la prévention intégrée au travail établie théoriquement, en considérant les perspectives des personnes exposées au concept. Méthode. Selon un devis de recherche descriptif interprétatif, des entrevues individuelles ont été réalisées auprès de 12 parties prenantes impliquées dans le continuum de la prévention des lésions professionnelles et de l’incapacité au travail. Une analyse thématique a été réalisée sur les données collectées. Résultats. Les résultats suggèrent que la prévention intégrée au travail se définit par cinq attributs : (1) vision holistique de la santé, (2) compréhension commune du but de la prévention intégrée, (3) communication entre les parties prenantes, (4) collaboration entre les parties prenantes, et (5) coordination des actions préventives. L’analyse a aussi permis de mettre en exergue les antécédents, ou prérequis à la mise en place du concept, de même que les conséquents, ou retombées qui en découlent. Conclusion. Cette étude offre une conceptualisation bonifiée et nuancée de la prévention intégrée au travail ainsi que des pistes d’application pratique.
Des livres pour « faire joli » ?
Authors: Le Bail Marine
Published: October 2024

Le livre peut-il être traité comme un simple objet décoratif ? Depuis le xixe siècle, moment où le livre devient progressivement un objet de consommation courante, jusqu’à aujourd’hui, où les réseaux sociaux font volontiers sa promotion en l’associant à des valeurs vintage et réconfortantes, le livre a intégré la grammaire des arts décoratifs et retenu l’attention des traités de décoration intérieure. Il donne lieu, dans ce cadre, à plusieurs scénographies expositionnelles qui en modulent l’inscription dans notre environnement quotidien. Au-delà, toutefois, de son intérêt esthétique, il alimente toute une théâtralisation du sujet dans son intérieur qui concerne au premier chef les hommes et les femmes de lettres et qui trouve aujourd’hui à se prolonger sous des formes inédites sur les réseaux sociaux comme TikTok ou Instagram. Toutefois, ces usages décoratifs se heurtent à des résistances tenaces qui révèlent la persistance d’une axiologie dominante subordonnant notre rapport au livre à l’activité de lecture. À rebours d’une approche qui consisterait à opposer schématiquement lecture et non-lecture pour mieux promouvoir la première et condamner la seconde, cet article entend précisément montrer que les usages décoratifs de l’objet-livre s’inscrivent dans le prolongement de notre rapport aux textes, dont ils constituent une expansion en contribuant à les inscrire visuellement dans notre environnement quotidien.
Les trois mémoires de l’Amérique latine
Authors: Rouquié Alain
Published: October 2024

La Conquête et l’esclavage des Africains sont des traumatismes originels qui forment le substrat des cultures et des mémoires des pays de l’Amérique latine. La violence d’État à la période contemporaine reflète les inégalités structurelles et les dominations sociales qui en procèdent.The Conquest and the enslavement of Africans are the original traumas that form the substratum of the cultures and memories of the countries of Latin America; State violence in the contemporary period reflects the structural inequalities and social dominations that result from them.
Mémoires coloniales conflictuelles
Authors: Bancel Nicolas , Blanchard Pascal
Published: October 2024

Alors que l’histoire coloniale a été largement éclairée par les travaux des historiens depuis les décolonisations, la socialisation de sa mémoire fait l’objet d’investissements concurrentiels depuis les années 1980. Cette contribution propose tout d’abord de comprendre le changement du régime des commémorations et l’inflexion de la mémoire collective portant sur la Seconde Guerre mondiale, depuis la reconnaissance de la responsabilité de la France dans la déportation des Juifs. Ensuite, nous explorons les projets de patrimonialisation de l’histoire coloniale – tous orientés vers une « valorisation » de l’histoire coloniale – depuis un premier projet lancé par François Mitterrand au début des années 1980 jusqu’au projet de mémorial porté par la droite et incluse dans la loi de 2005. Nous analysons également les différents projets muséographiques sur ce sujet dans plusieurs villes de France.
La colonisation et la guerre d’Algérie : un passé encore présent
Authors: Manceron Gilles
Published: October 2024

Épisodes majeurs dans les quatre siècles d’histoire coloniale française, les cent trente-deux ans de la colonisation de l’Algérie et tout particulièrement la « gangrène » qu’a représentée la guerre d’Algérie – pour reprendre le terme employé par Benjamin Stora en 1991 – continuent à peser sur notre présent. Ces épisodes de notre histoire sont à la fois invisibles et omniprésents. Ils sont « l’éléphant au milieu de la pièce » que personne ne voit. Or, dans nos analyses de la France d’aujourd’hui, la réflexion sur leurs traces actuelles doit occuper une place importante.
Shopkeepers and urban change: moving beyond gentrification studies?
Authors: Fleury Antoine , Rollinde Natacha
Published: October 2024

Though the literature on commercial gentrification has grown considerably since the 2000s, it has several blind spots. Indeed, research has primarily focused on neighborhoods located in central areas, examining the retail landscape as well as consumer practices and identities. In this article, we discuss this literature and put it in dialogue with the literature on retailers and, more broadly, on independent professions. On this basis, we propose an analytical framework for studying commercial change from the shopkeepers’ perspective. The discussion is conducted in light of the concrete transformations of a commercial street located in a formerly working-class suburb of Paris. This case study illustrates the relevance of our approach, showing that even in an archetypal gentrified street, the profiles and paths of shopkeepers are varied, as is their relation to urban change.
Consent and dissent in psychiatry. A study conference at the Catholic University on the political use of psychiatry
Authors: Ferri Eduardo
Published: October 2024

Not available.
A study of the diagnostic and prognostic role of enhancer of zeste homolog 2 and BRCA1-associated protein 1 expression in different prostatic lesions (an immunohistochemical study)
Authors: Saleh Samah I. , Soliman Amira E. , Aboelkheir Mona A.
Published: October 2024

Aim

To ascertain the applicability of enhancer of zeste homolog 2 (EZH2) and breast cancer gene 1 (BRCA1)-associated protein 1 (BAP-1) in the diagnosis of prostatic adenocarcinoma (PCa) as well as their correlation with different clinicopathological characteristics of PCa cases and the patients’ disease-free survival.

Patient and methods

This study included 10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasm PIN (HGPIN), and 60 cases of PCa. Immunohistochemical staining techniques were used to evaluate the roles of EZH-2 and BAP-1 in PCa and their correlations to different clinicopathological data and patient survival.

Results

High nuclear positivity of EZH2 was detected in 53.3% of PCa, while 80% of BPH and 66.7% of HGPIN cases showed no/low expression. Conversely, BAP1 nuclear positivity was detected in 70% of BPH and 50% of HGPIN versus 48.3% of PCa cases. Using the receiver-operating characteristic curve, the EZH2 showed 60.2% sensitivity, 83.3% specificity, and 65% diagnostic accuracy compared with BAP1 that showed 86.7, 51.7, and 58.7%, respectively. However, the markers showed 70% sensitivity, 56.2% specificity, and 67.1% diagnostic accuracy when tested synchronously. A statistically significant inverse relationship between EZH 2 and BAP1 nuclear expression in the examined PCa cases was found. Furthermore, EZH-2 overexpression and BAP-1 nuclear loss are associated with unfavorable clinicopathological characteristics. Moreover, it was demonstrated that EZH-2 overexpression and low patient survival were statistically correlated.

Conclusions

These results suggest that both EZH2 and BAP1 can be added to the diagnostic panel of PCa and can serve as potential independent prognostic biomarkers for predicting the outcome of patients.
Tetraspanin cluster of differentiation 151 expression is associated with unfavorable tumor behavior in muscle invasive urothelial carcinoma of the bladder
Authors: El-Dien Marwa M.S. , Gadallah Marwa S.A. , Alhanafy Alshimaa M. , Holah Nanis S.
Published: October 2024

Objective

Bladder carcinoma is the most prevalent malignant tumor involving the urinary system. In 2021, it is the tenth most common cancer worldwide. Various carcinomas showed overexpression of cluster of differentiation 151 (CD151), and it affects their behavior and clinical outcome. In addition to its prognostic role, CD151 might be a new promising therapeutic tool. Despite of the research about CD151 starting from 1990s, up to the best of our knowledge, very few studies have been reported its expression and role in bladder carcinoma. This study aimed to assess the expression of CD151 protein in urothelial carcinoma of the bladder (UCB) and clarify its significance regarding tumor behavior and clinical outcome.

Patients and Methods

The present study examined the immunohistochemical expression of CD151 in 71 archival cases of muscle invasive UCB.

Results

High CD151 percentage of expression was associated with advanced T stage (T3 and T4) and lymphovascular invasion. Higher CD151 optical density was associated with positive nodal status and presence of CD151
+
tumor infiltrating lymphocytes. Moreover, nucleocytoplasmic expression of CD151 showed significant association with presence of CD151
+
tumor infiltrating lymphocytes, perineural, and lymphovascular invasion. Tumor clinical stage is the independent prognostic factor affecting both overall and progression free survival.

Conclusion

CD151 might be an important factor in UCB tumorigenesis. Relation between CD151 and unfavorable tumor behavior suggest its role in facilitating tumor cell motility and invasion. The nuclear CD151 might have more roles can not be done by its cytoplasmic partner. Targeting CD151 could be a new therapeutic strategy in UCB.
Apolipoprotein C1 expression in molecular subtypes of breast cancer: clinical correlation and prognostic significance
Authors: Habashy Hany O. , Mahfouz Mena , Eltantawy Ahmed , Abdel-Rahman Manar A.
Published: October 2024

Background:

Breast cancer includes a wide spectrum of tumors with different morphological, molecular, and clinical phenotypes. Further discovery of new prognostic markers with therapeutic implications is warranted. Apolipoprotein C1 (APOC1) is a member of the apolipoprotein family located on chromosome 19 and participates in lipid transport and metabolism. Recently, some studies have explored its association with cancer development.

Material and Methods:

In this study, we aimed to study APOC1protein expression in molecular classes of breast carcinoma and to correlate its expression with other clinicopathologic variables using immunohistochemistry and tissue microarrays in 200 cases of breast cancer in Egyptian women.

Results:

High to moderate APOC1 cytoplasmic expression was observed in 57.5% of the cases. APOC1 expression was common in ER-negative and PR-negative cases in comparison to positive cases (P<0.001), while it was common in HER2-positive cases (P<0.001). Positive APOC1 cases showed a higher Ki67 proliferation index. Expression of APOC1 was more common in ductal followed by the lobular tumor type (P=0.002). Triple-negative basal-like breast cancer. (BLBC) showed the highest expression of APOC1, while the luminal A subtype showed the lowest expression level (P<0.001). Expression of APOC1 was more common in cases with recurrence than in cases without recurrence. Survival analysis showed that APOC1 was a significant prognostic marker for overall survival (log rank: 5.87, P=0.015) and disease-free survival (log rank: 15.86, P<0.001). Multivariate Cox regression analysis mortality showed that APOC1 is an independent prognostic marker with a hazard ratio of 1.47, confidence interval=1.08–1.99, and P value of 0.014.

Conclusion:

Our study showed a strong association between high APOC1 expressions and triple-negative basal-like breast cancer. APOC1-positive breast cancer showed a significantly shorter overall survival and disease-free interval. APOC1 is an independent predictor of mortality in our patient cohort supporting its role in breast cancer progression and highlighting its potential therapeutic implications.
Immunoscore in urothelial carcinoma as a prognostic predictor and its relation to grading and staging
Authors: Elmahdi Mohamed H. , Esmail Reham S. E. , Ibrahim Gehan A. , Shabana Marwa E.
Published: October 2024

Background

There is growing evidence that the immune system plays a major role in hindering tumor advancement. Tissue densities of CD3+ T lymphocytes and CD8+ cytotoxic T lymphocytes have been used to establish an Immunoscore (IS). It has been proven to be a robust prognostic tool in colorectal cancer, but it is not well investigated yet in bladder urothelial carcinoma.

Aim

We aimed to correlate IS in urothelial carcinoma with the different clinicopathologic parameters, to examine its validity and possible role in bladder urothelial carcinoma.

Patients and method

Forty cases of archived paraffin sections from patients diagnosed with bladder invasive urothelial carcinoma and underwent radical cystectomy, were examined for CD3+ and CD8+ by immunohistochemical means. Then, cell densities were measured in tumor core and invasive margins using the image analysis system. The correlations were evaluated between Immunoscore (IS) and characteristics of the included patients and tumor.

Results

IS and tumor stage had a significant connection (P=0.04), showing an inverse relationship, where elevated IS was seen in low T stages. T stages I and II had high IS values, while IS values tended to decrease in stages III and IV. alternately, no correlation has been detected between IS and any of (Patients’ age, sex, tumor size, site, histological type, gross appearance, multifocality, associated urinary bladder bilharziasis, nodal stage, histological grading, vascular or perineural invasion), with (P value >0.05).

Conclusion

Early-stage cancers have a much higher IS. This could be attributable to increased activation of immune cells with tumor antigens during the early stages of tumor progression in an attempt to destroy tumor cells. However, in the advanced phases, tumor cell suppressors modify the immune cells’ defensive capabilities to aid tumor progression. Consequently, studying the molecular nature of the tumors immunity provides ideas for predicting prognosis and determining factors associated with worse prognosis, as well as assisting in choosing the most suitable management plan. Since the IS has biomolecular relevance for assessing immune cell infiltrates, it could be used to develop innovative immunotherapy techniques.
Doderlein’s cytolytic vaginosis: a camouflage of white discharge per vaginum in pregnancy: a case report
Authors: Balakrishnan Padmapriya , Sharmila Vijayan
Published: October 2024

White discharge per vaginum (WDPV) in women is a routinely encountered gynaecological symptom in day today practice. Thorough history taking, per speculum and vaginal examination helps to identify the cause and also to further investigate it for pH and pap smear. The most frequent causes of WDPV are candidiasis, bacterial vaginosis and trichomoniasis. Interestingly lactobacillus/doderlein bacillus, a normal vaginal flora overgrow under the effects of oestrogen, can produce vaginal discharge in women of reproductive age group. Pap smear shows plenty of bare nuclei due to significant cytolysis of vaginal epithelial cells and lactobacillus overgrowth. The importance of vaginal discharge due to lactobacillus overgrowth is that it is refractory to routine medical management for other causes of vaginal discharge. We report doderlein cytolysis diagnosed by pap smear examination in a pregnant woman with history of vaginal discharge.
Coronary Sinus Anomalies with Case Illustrations
Authors: Chauhan Akshata J. , Kothari Richa Jayesh
Published: October 2024

Coronary sinus (CS) is the largest coronary vein that receives blood from all the venous tributaries of the heart. Its variations in anatomy are significant from the surgical point of view, especially in patients with complex congenital heart diseases (CHDs). CS anomalies are rare, but with increasing advancements in imaging, they are often diagnosed with cardiac computed tomography (CT). These are associated with other CHDs, so the radiologists are alerted to look further for different anomalies. The data in this study were collected from the routine contrast-enhanced CT examinations of the patients referred to the Department of Radiology, Narayana Hrudayalaya Hospital, Bengaluru, from January 2019 to August 2023. It was observed that the anomalies were seldom seen as a single entity and instead were seen as a part of the spectrum of anomalies such as persistent left superior vena cava (LSVC), Raghib complex, total anomalous pulmonary venous connection, and interrupted inferior vena cava. Out of these, the most common associated anomaly was found to be persistent LSVC. These anomalies are essential to detect in the preoperative assessment because they may cause significant morbidity in some cases if left uncorrected. Therefore, we must search for other cardiac anomalies when encountering CS anomalies.
Comparison of Different Prognostic Scoring Systems in Predicting the Severity and Outcome in Alcoholic Hepatitis in Indian Patients
Authors: Dhiman Priyank , Grewal Ritu , Puri Pankaj , Issar Neel Kanth , Prasad AS , Jain Rahul , Kalra Manasvi , Jain Harshul
Published: October 2024

Introduction:

Alcohol abuse causes a variety of liver diseases including alcoholic steatosis, alcoholic hepatitis (AH), liver fibrosis, cirrhosis, and hepatocellular carcinoma. AH is a clinical syndrome which typically occurs after the harmful use of alcohol. There are mild forms that are likely to improve with conservative management, whereas severe cases are associated with a high mortality rate and have a high risk of death despite treatment. The identification of severe AH is important, as this can be associated with 30%–50% short-term mortality. Existing prognostic scores have been validated in the western population, and the data of application in the Indian population are scant.

Materials and Methods:

It is a prospective observational study conducted for 2 years at Tertiary Care Hospital Army Hospital (Research and Referral) Delhi. The sample size was kept to be 45. For each patient, clinical and laboratory values were obtained on the day of admission and used to calculate the prognostic models according to their formulas. The various scores – Maddrey’s discriminant function (mDF), Glasgow AH score (GAHS), age, bilirubin, international normalized ratio (INR), creatinine score, and model of end-stage liver disease (MELD) including its modification MELD-sodium were calculated. For patients started on steroids, early changes in bilirubin level and Lille score were calculated.

Results:

All the prognostic scores were found to be good predictors of mortality. When compared with each other, MELD was most indicative of mortality with maximum area under the receiver operating characteristic curve. All the scores were significantly higher in the nonsurvivors than the survivors (P < 0.0001).

Conclusion:

AH is a clinical syndrome that occurs after the harmful use of alcohol and confers a high mortality. Effective treatment and support for patients with AH is dependent on a proper assessment of the disease severity and estimation of the risk of death as early in the course of the disease as possible.