bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of curing time on polymer concrete strength
Authors: Cakir Ferit
Published: June 2022

With the advancement of polymer technology, polymer concrete (PC) has become increasingly popular throughout the world and it has among the major construction materials due to its many advantages. The strength and durability of PCs are directly related to paste quality and curing time. The curing time is of the utmost importance to ensure desirable mechanical properties. An understanding of the strength-time relationship of PCs is crucial to understanding the effects of loading on concrete at an older age. The objective of this paper is to study the behavior of PC under different curing times with an emphasis on compressive and flexural strengths. Therefore, a total of 63 specimens were tested at seven different ages (1 day, 3 days, 5 days, 7 days, 14 days, 28 days, and 105 days) throughout the study. According to the results obtained from the tests, it is shown that the curing time plays a critical role in the flexural and compressive strengths of PCs. PCs gain more than 80% of their mechanical strength within three days, and the long-term strength does not change significantly after seven days.
Minimum weight design of reinforced concrete beams utilizing grey wolf and backtracking search optimization algorithms
Authors: Tunca Osman , Çarbaş Serdar
Published: June 2022

In this study, optimal weight design of a reinforced concrete beam subjected to various loading conditions is investigated. The purpose of the optimization is to attain the minimum weight design of the reinforced concrete beam under distributed and two-point loads. The design problem is handled under three different design load cases. The two-point loads are affected on beam-to-beam connection nodes of reinforced concrete beams. Thus, while the magnitudes of distributed load and two-points load are remained constant, the distances between two-points loads are taken as 2m, 3m and 4m, respectively. The width and height of the rectangular cross-section of the concrete beam, and the diameters of the longitudinal and confinement steel rebars are treated as design variables of the optimum design problem. The design constraints of the optimization problem consist of the geometric constraints and necessities of the Turkish Requirements for Design and Construction of Reinforced Concrete Structures (TS500), and Turkish Building Earthquake Code (TBEC). As two novel metaheuristics, grey wolf (GW) and backtracking search (BS) optimization algorithms are selected as optimizers. Both algorithms are independently operated five times for three different design problems. Thus, the obtained results are examined statistically to compare in accordance with algorithmic performances. The optimal findings from optimization algorithms show that the GW algorithm is a little bit more robust on the exploitation phase, while the BS algorithm is stronger on the exploration phase. Moreover, it can be deducted from optimal beam designs that the GW algorithm is more viable to minimize reinforced concrete beam design.
Evaluating effects of granulated glass on structural and seismic behavior of tall RC structures using experimental tests and 3D modeling
Authors: Karalar Memduh , Çavuşlu Murat
Published: June 2022

The use of waste materials for reinforcement of reinforced concrete (RC) structures is of great importance for both environmental cleaning and recycling. In this study, the effects of granulated glass released by factories on the structural behavior of RC structures are examined in detail. Initially, 5 different concretes are produced using 5 different granulated glass percentages. Granulated glass is used instead of aggregate. Different aggregate ratios of granulated glass are taken into account for each sample. 5 different concrete samples are subjected to the slump test and the consistency of the concrete samples is assessed in detail. Then, each concrete sample is subjected to compressive strength tests. It is clearly seen from the compressive strength tests that granulated glass increased the strength of the concrete noticeably. Then, the 31-story reinforced concrete structure is modeled considering the most critical granulated glass ratio. The 1995 Kobe earthquake is utilized for the seismic analyses. Firstly, the RC structure is analyzed for the pure concrete and then, analyses are performed for various granulated glass added cases. According to the analysis results, granulated glass significantly increased the earthquake resistance of reinforced concrete structures. Furthermore, waste granulated glass caused enormous reductions in the weight of the structure. In this study, it is concluded that granulated glass material, which is found in nature as waste, can be used for the construction of RC structures.
Bentuk Kelembagaan Dan Dampak Pemberdayaan Masyarakat Melalui Pemanenan Madu Hutan (Apis Dorsata) Di Taman Nasional Ujung Kulon
Authors: . Ramawati , Ekawati Sulistya , Kurniasari Dewi Ratna
Published: June 2022

National Park Management is faced with conflicts of interest in conservation and community economics. A partnership is one of the answers to this problem. The study was conducted in the buffer area of Ujung Kulon National Park involving 17 respondents who were selected by purposive sampling. The results showed that the communities involved in the partnership gained legal access to harvest wild honey in forest areas, as well as ease of market access and decent prices. The partnership pattern builds awareness of farmer groups to maintain forest sustainability. They realize that if the forest is maintained, it will increase the wild honey harvest and their income.
Strategi Pengelolaan Ekowisata Mangrove Pulau Bangkobangkoang Kabupaten Pangkep, Sulawesi Selatan
Authors: Juanda Muhammad Faisal , Arfan Amal , . Maddatuang , Umar Ramli , Maru Rosmini , . Anshari
Published: June 2022

Mangrove forest on Bangkobangkoang Island has the potential to be managed to become an ecotourism area. Such management requires a strategy to provide both economic and ecological benefits. The purpose of the study was to analyze the ecotourism management strategy of mangrove forests on Bangkobangkoang Island, Pangkep Regency, South Sulawesi. The sampling technique used is purposive. Data collection techniques are observations and surveys on mangrove forests, questionnaires, and interviews with island communities. The analysis technique used is SWOT. The results showed that the mangrove forest of Bangkobangkoang Island has a thickness of 230.39 m, a density of 23.25 ind/100m2, tides as high as 1.49 m, and there are 5 species of mangrove found and aquatic biota, birds, and others. The priority strategy is to maximize the potential of mangrove forests and preserve their naturalness so that they become a means of education to improve the community's economy, Coordination and communication between community members and the government in efforts to manage ecotourism areas, Empower fisherman groups in managing ecotourism, Procurement of supporting facilities for monitoring mangrove ecosystems, Training on product making made from mangroves to increase community income and maintain and strengthen community participation and interest in managing mangrove forests into ecotourism areas. This research can be input for stakeholders in making policies.
Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site
Authors: Wei Xi , Wang Meng , Wang Xiaoqing , Zheng Xiangqian , Li Ying , Pan Yi , Li Yueguo , Mu Jiali , Yu Yang , Li Dapeng , Gao Ming , Zhang Sheng
Published: June 2022

Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma (PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis. Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed. We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models. The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status. Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement. In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level VI, ipsilateral or skip cervical lymph node metastases. The cut-off value of the ratio of abutment/perimeter of the PTMC primary site (25%) was significantly correlated with cervical lymph node metastases (P = 0.000). Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients.
Decrease in the Ki67 index during neoadjuvant chemotherapy predicts favorable relapse-free survival in patients with locally advanced breast cancer
Authors: Chen Chunfa , Zhang Yuling , Huang Ziyi , Wu Jundong , Huang Wenhe , Zhang Guojun
Published: June 2022

Objective: The purpose of this study was to explore the optimal cutoffs of the three parameters of Ki67 during NAC for predicting patient prognosis and investigate whether the optimal cutoffs of the Ki67 values were associated with relapse-free survival (RFS) or breast cancer-specific survival (BCSS). Methods: A total of 92 patients with locally advanced breast cancer (LABC), who had residual disease after NAC were retrospectively investigated. The optimal cutoff values of the Ki67 parameters were assessed by the online algorithm Cutoff Finder. Kaplan-Meier analysis, the log-rank test and Cox regression analysis were carried out to analyze survival. Results: The optimal cutoff values for the postsurgical Ki67 level and the decrease in the Ki67 level during NAC were defined as 25% and 12.5%, respectively. According to the univariate survival analysis, a higher Ki67 level in residual disease was associated with poor RFS (P = 0.004) and BCSS (P = 0.014). In addition, a Ki67 expression decrease > 12.5% during NAC was related to favorable RFS ( P = 0.007), but was not related to BCSS (P = 0.452). Cox regression analysis showed that the Ki67 expression decrease (> 12.5% vs. = 12.5%) and histological grade (grade 3 vs. grade 1-2) were the independent factors associated with RFS (P = 0.020 and P = 0.023, respectively), with HR values of 0.353 (95% CI: 0.147-0.850) and 3.422 (95% CI: 1.188-9.858), respectively. Conclusions: The Ki67 decrease was one of the independent factors associated with RFS in LABC patients with residual disease after receiving NAC.
The Rectifying Contact of Hydrated Multi-Dimensional YSZ Nanoparticles for Advanced Electronics
Authors: Doroshkevich Alexander , Zakharova Anna , Oksengendler Boris , Lyubchyk Andriy , Tatarinova Alisa , Kirillov Andriy , Vasilenko Tatyana , Gorban Oksana , Bodnarchuk Viktor , Nikiforova Nadejda , Zakharova Elena , Balasoiu Maria , Mardare Diana , Mita Carmen , Stanculescu Anca , Mirzayev Matlab , Nabiyev Asif , Popov Evgeni , Khiem Le Hong , Donkov Aleksandr , Konstantinova Tatyana
Published: June 2022

The paper considers new effects of the nanoscale state of matter, which open up prospects for the creation of electronic devices using new physical principles. The contact of chemically homogeneous different sizes hydrated nanoparticles of yttrium-stabilized zirconium oxide (ZrO2 – x %mol Y2O3, x=0, 3, 4, 8; YSZ) with particle sizes of 7.5 nm and 7,5 nm; 7.5 nm and 9 nm; 7.5 nm and 11 nm; 7.5 nm and 14 nm in the form of compacts obtained using high hydrostatic pressure (HP-compacts of 300MPa) was studied at direct and alternating current. A unique size effect of the nonlinear (semiconductor) dependence of the electrical properties (in the region U <2.5 V, I ≤ 2.7 mA) of the contact of different-sized YSZ nanoparticles of the same chemical composition is revealed, which indicates the possibility of creating semiconductor structures of a new type based on chemically homogeneous nanostructured systems. The electronic structure of the near-surface regions of nanoparticles of a special type of oxide materials and the possibility, on this basis, to obtain specifically rectifying properties of the contacts were studied theoretically. Models of surface states of the Tamm type are constructed, but considering the Coulomb long-range action. The discovered variance and its dependence on the curvature of the surface of nanoparticles made it possible to study the conditions for the formation of a contact potential difference in cases of nanoparticles of the same radius (synergistic effect), different radii (doped and undoped variants), as well as to discover the possibility of describing a group of powder particles from material within the Anderson model. The established effect makes it possible to solve the problem of diffusion instability of semiconductor heterojunctions and opens up prospects for creating electronics devices with a fundamentally new level of properties for use in various fields of the national economy and breakthrough critical technologies.
Higher Education Enrollment, Graduation, and Employment Trends in Ethiopia: An Empirical Analysis
Authors: Yimer Berhanu Mekonnen , Demissie Mesfin Molla , Herut Adane Hailu , Bareke Misganu Legesse , Agezew Birhanu Haile , Dedho Negash Haile , Lebeta Mulugeta Fufa
Published: June 2022

The purpose of this study was to investigate trends in undergraduate enrollment, graduation, and employment in Ethiopia. It looked at data from the past 20 years of enrollment and graduation, as well as the 15 years of unemployment trends. For enrollment, we used the ARIMA(0,1,0) model, for graduation, the Holt-Winter model, and unemployment, the Simple model. Results showed that enrollment rates increased dramatically, but graduation rates remained constant. Besides, enrollment is expected to continue rising, while graduation rates are expected to fall. On the other hand, between 1999 and 2018, the overall unemployment trend declined. Yet, between 2009 and 2018 the unemployment trends stayed stable. According to the findings, for the next ten years, higher education enrollment and graduation will continue. Nevertheless, it is shown the diminishing demand for jobs in the labor market. As part of improving the existing realities of higher education, the study suggests reconsidering job-driven policy formulation, strengthening higher education-labor market alignment, controlling higher education expansion, and sustaining the development qualification systems.
The use of the precautionary principle and the non-refoulement principle in public law
Authors: Olajos István , Mercz Mónika
Published: June 2022

In addition to interpreting the precautionary principle, the present article shows that this principle of environmental law applies to agricultural practice as well. In a separate chapter, we analyze the relationship between the non-refoulement (also known as non-derogation) principle and the precautionary principle in connection with the latest cases of the Hungarian Constitutional Court’s practice. This article summarizes the counter-arguments of the constitutional judges against a strong interpretation of the precautionary principle and analyzes whether a strong interpretation of said principle prevails in the practice of the Deputy Ombudsman for Future Generations.
Kantian “Copernican Revolution”: Synthesis of Empirical Realism and Transcendental Idealism
Authors:   State Academic University of the Humanities, Katrechko Sergey L.
Published: June 2022

Transcendental philosophy of Kant is the first theory of experience (scientific knowledge) related to the solution of the (semantic) problem set in his famous letter to M. Hertz: what is the ground of the relation of the representation to the object? There are two ways to solve it, and Kant himself chooses the sec­ond of them, thus making his “Copernican Revolution”. Does the idea that Kant is an idealist follow from that, all the more as he often refers to his phi­losophy as to transcendental idealism? The analysis of the internal structure of this revolution shows that it is possible to highlight two vectors: the empiri­cal, from the thing-in-itself to representations, and the noumenal ones, from the transcendental unity of apperception or transcendental object to the thing-as-it-appears-to-us. Keeping empirical vector says that Kant’s theory of experi­ence is an empirical realism and his transcendentalism is a reflective (meta – level) epistemological (methodological) superstructure above it. Our semantic interpretation of Kant meets the modern “revolutionary” interpretation of tran­scendentalism, developed in the works of G. Bird, G. Prauss, H. Allison et al., which was called as the theory of “two aspects”. On this basis, we develop a realistic interpretation transcendentalism, which is relatable to the contem­porary interpretation of Kant, represented in works of W. Röd, A. Collins, P. Abela, K. Westphal, L. Allais and others.
Marxism as Alternative Project within Secularized Protestantism
Authors:   Lomonosov Moscow State University, Shchipkov Aleksandr V. , Shchipkov Vasily A. ,   MGIMO-University
Published: June 2022

The article views the problem of Marxist heritage from the standpoint of social Christianity. The authors urge to overcome the stereotype of considering Marxism as a conceptual and ideological antithesis to liberalism. The authors consider it practicable and imperative that Marxism should be viewed as a socio-philosoph­ical trend that had arisen within the framework of secularised Protestantism or cultural Protestantism. It can be considered more moderate than secular Protestant fundamentalism, whose political and economic ideology is based on liberalism. Having emerged in the cultural and intellectual field of the European Reformation and as its partial negation, Marxism can be described as a critical commentary on it. The goal of Marxism is to combine biblical (Abrahamic) values with the prot­estant values of Progress understood in a utilitarian way, thereby rejecting histor­ical religions. According to the authors, the Marxism program was afflicted by in­ternal contradictions and was therefore doomed to failure. The authors go on to declare the historical inevitability of the collapse of liberal capitalism and to jus­tify his position from the standpoint of social Christianity.
“Good and wise friends”, zenchishiki, in Japanese Buddhist Thought
Authors:   MGIMO University, Gorenko Igor V. , Trubnikova Nadezhda N. ,   Institute of Philosophy, Russian Academy of Sciences
Published: June 2022

The purpose of the article is to consider one of the aspects of the understanding of friendship in Buddhist thought (according to Japanese sources) in comparison with the meaning given to the concept of friendship in Christian thought. In Ja­panese Buddhism, the term zenchishiki (Skt. kalyāṇa mitra) means a “good and wise friend” in general, and in a narrower sense, someone who helps the dying person meet death with the right thoughts. The tasks of a friend at his deathbed partly coincide with “care for the sick”, partly opposed to it. Zenchishiki main­tains the proper mood of the dying at the hour of death; if in the case of caring for the sick, it is a matter of bodily suffering that can be weakened, then in the case of zenchishiki, it is about suffering that cannot be canceled; in the first case, the stronger takes care of the weak; in the second, two mortals are on an equal footing, although one had to die before the other. The Japanese instructions for death hour rituals formalized the role of zenchishiki to a large extent, and its original meaning was lost. The question of friendship at the hour of death, of good and bad friends, is again discussed in essence by Kamo no Chōmei in Hosshinshū (1210s). He shows zenchishiki at work, gives examples of how peo­ple choose their friends for the hour of death, talks about the experience of friendship or enmity of a person with himself: relationships with other people are built on this experience, and this experience itself changes under their influence.
Royal Voyages of Hirohito: Changing of Image of the Japanese Sovereign in 20th Century (as Seen Through the Function of Movement)
Authors:   National Research University Higher School of Economics, Rodin Stepan A.
Published: June 2022

Through many centuries tenno, or the emperors of Japan, while being nominally the higher rulers of the country, were in fact deprived from the function of movement in their image, and such means of representation of their power, as tours around the country or voyages abroad, were absent from their governing instruments. From the beginning of Meiji period, the image of the sovereign had undergone many changes, partially due to the western influence and foreign views on the role and the functions of the ruler. The attempt to make tenno more like a public figure made by the Japanese elites led to the necessity of conducting imperial trips around the country, so the ruler could face life conditions of his subjects. Emperor Meiji was the first tenno to take such a journey. Other imperial ancestors, including crown princes, had also become more mobile from that time on. The case of Hirohito’s voyages as a crown prince and then as the emperor is one of the great interests as it enlightens the view of the imperial power and its functions through different stages of its evolution in the 20th century. This paper describes four major historical trips by Hirohito and analyzes their symbolical and political significance.
Dialectics of the Counter-Enlightenment
Authors:   Lomonosov Moscow State University, Mezhuev Boris V.
Published: June 2022

The article is devoted to the theoretical explication of the concept of “Counter-en­lightenment”, which is being debated today in Western thought's historiography. The term gained currency after a famous 1973 essay by the English thinker Isaiah Berlin, and it described various attempts to criticize the philosophy of the French Enlightenment. In this material, the Counter-Enlightenment is considered a socio-philosophical project that starts from the idea that modern man has not yet reached maturity or adulthood, which would allow him to rely solely on his mind, without relying on external authority. Various variants of counter-enlightenment thought are considered in the example of material, primarily domestic philosophy. It is con­cluded that the Counter-Enlightenment can have not only a traditionalist, but also a futuristic character, and such a denial of the coming of age of a modern person would imply the recognition of the power of certain messengers from the future, in the role of which, in modern technocratic utopias, artificial intelligence also acts. The general conclusion to which the article comes is that the contemporary epoch is a dialectical combination of Enlightenment and Counter-Enlightenment projects, the clash of which largely determines the dynamics of the modern era.
Publicity as a Problem of Philosophy: Returning to J. Dewey’s Ideas
Authors:   Moscow Pedagogical State University, Kozlova Natalya Yu.
Published: June 2022

The article analyses John Dewey’s ideas on the ‘recovery’ or ‘reconstruction’ of philosophy. Essential to the life of society and inextricable from its condition, philosophy can provide a tool for the prevention of social cataclysms. Yet some cataclysms are conditioned by philosophy – the matrix of thinking that has un­derpinned culture for two thousand years. Dewey’s approach to the tasks of philosophy is radical: the way to the intellectual transformation of society is through the reconstruction or ‘recovery’ of philosophical discourse. This point of view is juxtaposed with attempts found in the literature to limit the function of public philosophy to politicisation. The study investigates the ideas of Walter Lippmann and Michael Sandel, which are crucial for the approach in question, about public philosophy as a changing political reality. The major lines of Dewey’s ‘reconstruction’ of philosophy are examined, with special attention paid to the critical revision of the metaphysical foundations of philosophy and the re­consideration of the problem of the subject-object relationship. Arguments are made in favour of these ideas having the potential for stimulating the modern public ‘upgrade’ of philosophy and transforming current intellectual and educa­tional practices. In ceasing to be a theoretical tool to solve specific philosophical tasks, philosophy may become an intellectual method used by philosophers to eliminate urgent problems of the modern age
Pedagogy in the Сonstellation of Sciences: Methodological Dialogue and “Knowledge Transfer”
Authors:   I.M. Sechenov First Moscow State Medical University, Korzhuev Andrey V. , Ikrennikova Yuliya B. ,   Russian State Academy of Intellectual Property, Kuliev Zakir A. ,   I.M. Sechenov First Moscow State Medical University, Ryazanova Elena L. ,   I.M. Sechenov First Moscow State Medical University, Shadrina Elena N. ,   I.M. Sechenov First Moscow State Medical University
Published: June 2022

According to representatives of the exact sciences, as well as philosophers and methodologists of the humanities, the epistemological status of pedagogy today is quite low. There are no verified regulations for the empirical, theoretical and contextual substantiation of conclusions and methods for obtaining them; the voices of the theoreticians of pedagogical science about the structure and component composition of pedagogical theory sound polyphonic. The differences between theory and concept, long recognized in the science of science, do not find the right understanding and response in pedagogical works. Pedagogy, being an integral member of the community of human sciences, must today enter into an active and meaningful scientific dialogue with methodologists, science scholars, humanists, who represent a “strong” version of human knowledge. De­scribed by the famous Russian philosopher L.A. Mikeshina’s methodological dia­logues prompted us to take up the urgently required concretization of the author’s interesting conclusions and arguments in relation to the methodology of pedagogy which L.A. Mikeshina presents as transfer of terms (extrapolation). Based on the analysis of the cited book and many works of philosophers and teachers, we man­aged to build a triad of criteria for correct extrapolation of terms: a) address cor­rectness; correspondence of the pedagogical sound of the term transferred to ped­agogy to that which is accepted in donor science; b) the creative focus of the transferred term; c) detachment from repetition of the well-known method of noise stylistic reproduction. As one of the examples of the transfer of knowledge into pedagogy, the author considers the absorption by the science of education of the stylistics of related sciences based on scientific metaphors. The second part of the article is devoted to the theoretical construction of pedagogy. A methodologi­cal screen of a particular pedagogical theory is presented, white spots of the topic are revealed, the idea of theoretical constructions in pedagogy, reflected qualita­tively and quantitatively, is proposed. The connection between the problem of knowledge transfer (1) and the theoretical construction of pedagogy (2) is shown.
Christian Physicalism: on the Frontiers of Orthodoxy Anthropology and Analytic Philosophy of Mind
Authors:   Institute of Philosophy, Russian Academy of Sciences, Pavlov Alexey S.
Published: June 2022

This article attempts to develop Christian Physicalism within the boundaries of Orthodoxy theology, and it also offers an assessment of their conceptual compat­ibility. Christian Physicalism is the result of the application of the physicalist ap­proach in the analytic philosophy of mind to the circle of problems of Analytic Theology. This is a thesis postulating the physical character of the soul. It im­plies anthropological monophysitism because it holds that body and soul have the same nature. Orthodoxy Theology generally operates within the framework of ancient philosophy while Christian Physicalism is the crown of the contempo­rary analytic tradition. Comparison of these two types of discourses is possible since Christian Physicalism it do not touch the dogmatized areas of Orthodoxy Theology. However, it implies some substantial consequences both for the whole of Christian Anthropology and for the Chalcedonian Christology in many re­spects proceeding from it. In particular, difficulties arise in explaining human posthumous experience, the hypostatic identity of Christ, and trichotomous an­thropological models. Moreover, there is not clear whether physicalists’ views on these questions are compatible with the Christian worldview at all. The latter characterized by the idea of the personal and phenomenal character of human ex­perience. The main question, therefore, is what kind of explanation of these at­tributes does Christian Physicalism offer? The theoretical speculations of Chris­tian Physicalism go against not only the beliefs of common-sense but also the strong intuitions of a religious worldview. But the point is not so much in the ter­minology of analytical metaphysics, as in the very human way of describing the world. Trying to think rationally about God, we use concepts designed to de­scribe the facts of the physical world, which inevitably leads to a biasing of our picture of the world.
A Hybrid Approach Based Diet Recommendation System using ML and Big Data Analytics
Authors: Lambay Muhib Anwar , Mohideen S.Pakkir
Published: June 2022

Recommendations are useful suggestions used by people from all walks of life. However, the usage of recommender systems became indispensable in modern applications. They are found in different domains such as E-commerce. Concerning the health care industry, recommendations play a very crucial role. This industry has significance as it is linked to the lives of people and their well-being. Human health depends on the diet followed. Keeping this fact in mind, in this paper, we investigated healthy diet recommendations. The recommender systems that are existing in healthcare-focused a little in this area. As food decides health, it is to be given paramount importance. In this paper, we proposed a hybrid mechanism based on Artificial Intelligence (AI) for big data analytics. Particularly we used Machine Learning (ML) for generating healthy diet recommendations. The proposed system is known as Hybrid Recommender System (HRS). It involves a hybrid approach with Natural Language Processing (NLP) and machine learning. An algorithm named Intelligent Recommender for Healthy Diet (IR-HD) is proposed to analyze data and provide healthy diet recommendations. IR-HD could generate recommendations on a healthy diet and outperform existing models. Python data science platform is used to implement the recommender system. The results of experiments showed that the system is capable of providing quality recommendations and it has performance improvement over the state of the art.
Rapid evidence synthesis to enable innovation and adoption in health and social care
Authors: Norman Gill , Wilson Paul , Dumville Jo , Bower Peter , Cullum Nicky
Published: June 2022

BackgroundThe rapid identification and adoption of effective innovations in healthcare is a known challenge. The strongest evidence base for innovations can be provided by evidence synthesis, but this is frequently a lengthy process and even rapid versions of this can be time-consuming and complex. In the UK, the Accelerated Access Review and Academic Health Science Network (AHSN) have provided the impetus to develop a faster pathway for identification and adoption of high value innovations in the English NHS. MethodsThe Greater Manchester Applied Research Collaboration (ARC-GM) developed a framework for a rapid evidence synthesis (RES) process, which is highly integrated within the innovation pipeline of the Greater Manchester AHSN and the associated health care and research ecosystem. The RES uses evidence synthesis approaches and draws on the GRADE Evidence to Decision framework to provide rapid assessments of the existing evidence and its relevance for the decision-making process. We implemented this in a real-time context of decision-making around adoption of innovative health technologies.ResultsKey stakeholders in the Greater Manchester decision-making process for healthcare innovations have found that our approach is both timely and flexible, making it a useful input to considerations of innovation for adoption. The RES also identifies limitations of the evidence base for innovations subsequently adopted for roll-out, informing the evaluations planned subsequent to implementation. There is substantial interest from other ARCs and AHSNs in implementing a similar process.ConclusionsThe RES framework we have implemented aims to combine transparency and consistency with flexibility and rapidity, to maximise utility in a real-time decision-making context for healthcare innovations.
A report of short term spontaneous regression of herniated lumbar disc.
Authors: UNNITHAN AJAYA KUMAR AYYAPPAN
Published: June 2022

Background and importance:Spontaneous regression of herniated lumbar discs over a course of time is well documented in literature. But the concomitant relief of symptoms is not seen always. The reports of regression within 3 months are a few. Kim ES et al reported about the peroperative identification of regression of an extruded disc fragment, during microdiscectomy 2 months after the magnetic resonance imgaging(MRI).Clinical presentation:A 58-year lady presented with backache, left leg pain, and weakness for 3 months. A magnetic resonance imaging ( MRI) scan of lumbosacral spine, taken three months back, showed L3-4 disc extrusion and canal stenosis and grade 1 listhesis at L5-S1. She had improvement with conservative treatment. But she had recurrence of symptoms 10 days back. Straight leg raising test was positive at 40 degree on left side. Dorsiflexion was grade 4 on left side. Sensations of touch and vibration were reduced in L4 dermatomal region.A repeat MRI scan was done to plan surgery. The disc extrusion at L3-4 had shrunk, with the residual listhesis at L5-S1. She was given gabapentin, methylcobolamine, and physiotherapy. She improved over 1 week.Conclusion:Spontaneous regression of herniated lumbar disc can occur within three months, without corresponding symptomatic relief. So it is better to do a repeat imaging before planning surgery for a patient with a prior diagnosis of disc herniation. Thus an unnecessary surgery can be avoided.
Key role for mitochondrial complex I assembly factor ECSIT and mitochondrial metabolism in controlling intestinal homeostasis and tumorigenesis by regulation of translation of YAP protein
Authors: Yang Shuo , Wang Bingwei , Moynagh Paul , Wen Shuang , Liu Lu , Wu Chunyan , Chen Min , Ma Chanyuan , Yang Yongbing , Hu Yingchao , Ma Chunmei , Jiang Yuying
Published: June 2022

The intestinal epithelium is the fastest renewing tissue in mammals and has extensive flexibility to adapt to different types of damage. The orderly expression and activation of the YAP protein is the initial step in driving intestinal development and crucial for intestinal regenerative responses and regulating intestinal homeostasis[1–4]. However, the regulatory mechanisms controlling this process are still unknown. Mitochondria are enriched in the intestinal epithelium and particularly along the crypt-villus axis [5]. But we have little known about the role of mitochondria in maintaining intestinal homeostasis and regulating cell fate determination. In this study, we discovered that mitochondrial complex I assembly was the top enriched mitochondrial gene ontology (GO) along the crypt-villus axis, and ECSIT, the core subunit of Mitochondrial Complex I Intermediate Assembly (MCIA) complex [6, 7], was the top up-regulated mitochondrial factor I factor among this ontology. Intestinal cell-specific ablation of ECSIT results in the dysregulation of intestinal epithelial cell (IEC) differentiation and the development of a spontaneous intestinal inflammation phenotype. Single-cell RNA sequencing also revealed that mice lacking ECSIT in intestinal cells displayed a distinct, early proliferation- type signature in all the major intestinal cells, which we term “-like” cells. The “-like” cells are marked by high YAP protein and downstream YAP transcriptional programs but have no alteration in Yap mRNA level. Mechanistically, we show that the absence of ECSIT in intestinal cells promotes YAP translation initiation through the upregulation of the eIF4F complex. This upregulation is due to the reduced DNA methylation in genes encoding eIF4A1 and eIF4G2. Such DNA methylation reduction is caused by the increased a-ketoglutarate (a-KG): succinate ratio activating Ten-eleven translocation (TET)-dependent DNA demethylation in ECSIT deficient cells. Moreover, decreased ECSIT expression in intestinal cells enhanced susceptibility to tumorigenesis in the context of dysregulated WNT signaling, and the expression of ECSIT is positively correlated with the survival of patients with colorectal cancer. Together, our results reveal a novel and important role of the mitochondrial complex I assembly factor ECSIT and mitochondrial metabolism in maintaining optimal intestinal homeostasis and controlling the development of tumorigenesis by critical regulation of the eIF4F-YAP signalling axis.
Uncertainty analysis in probabilistic design of detention rockfill dams using Monte-Carlo Simulation model and probabilistic frequency analysis of stability factors
Authors: Riyahi Mohammad Mehdi , Riahi-Madvar Hossien
Published: June 2022

The detention rockfill dams are of crucial significance in engineering flood control projects due to their minimal technical requirement, low cost, minimal environmental effects, self-automotive operation process. However, the reliable design of detention rockfill dams is a challenging topic because of the complex interaction between the coarse porous rockfill material and the flow, the non-Darcian flow in rockfills, their stability encountered with floods, reliable flood peak reduction, and safe flood discharge release to the downstream. The present study aims to investigate and evaluate the influence of aleatory uncertainties (i.e., rockfill material, hydrologic, hydraulic and geometric uncertainties) in the reliable design of detention rockfill dams. In this study a reliable design framework of detention rockfill dams is developed with a focus on the importance of stability of rockfill dams against the floods. The developed framework is used to acquire future detention rockfill dam design and modeling requirements. The stability analysis, neglected in previous literature of rockfill dams, is performed under the uncertain design parameters. The uncertainty of input parameters in model design consideration is investigated including the uncertainties of inlet hydrograph, volume-elevation relation of reservoir, non-Darcian stage-discharge equation in coarse rockfill material, non-linear flood routing in detention rockfill dams. The effects of design uncertainty sources on the stability of dam, safety factors of overturning, sliding and bearing, along with the hydraulic performance of the dam were tested. The results in the present study revealed that the uncertainties in the input parameters of the model can effectively produce uncertainties in the hydraulic performance of detention rockfill dams ranges from − 53.54 to + 110.11 percent. Finally, the effects of input uncertainties on the structural stability and safety factors in detention rockfill dams is investigated. The results revealed the safety factor against the sliding (SFS) has maximum dependencies with the uncertainties ranging − 32.63 to 87.81 percent. Using the Monte-Carlo Simulation (MCS) and fitting probability distribution functions to the safety factor histograms, the best PDF is selected by the goodness of fitting tests to determine the improvement percentages in safety factors. The MCS and uncertainty quantifications results in 88.3 percent in increasing the safety factors as a reliable methodology for stability design of detention rockfill dams. Thus, the study calls for reliable, certain and safe design of flood protection rockfill ponds.
The effect of Mir-181a-5p on the prognosis of LUAD patients through targeted regulation of GTSE1 expression
Authors: Yang Xitong
Published: June 2022

Studying the regulatory mechanism and clinical application of target genes in LUAD can further provide theoretical basis. LUAD expression data were downloaded from the UCSC database, miRNA data were obtained from the TCGA database, and DEGs were derived by analyzing expression data using R software. The genes associated with LUAD were then obtained by survival analysis, and among them, clear LUAD target genes were screened. In-depth analysis of the GEPIA database yielded differences in normal and tumor tissues of LUAD patients, while comparing DFS and OS of target genes in LUAD. The Relevant IncRNA was derived from mRNA and miRNA analysis, and the correlation between immune cell content and target gene copy number, as well as the correlation between target genes and immune checkpoint-related genes CD274, PDCD1 and CTLA4 were analyzed by Timer database. The results indicated that GTSE1 expression was significantly higher in LUAD tumor tissues than normal tissues, and the survival rates of OS and DFS were significantly lower in patients with high GTSE1 expression than in the low expression group. GSEA analysis of GTSE1 was mainly involved in LUAD through Biocarta ranms pathway. According to the R software, mir-181a-5p was the GTSE1 target miRNA and GTSE1 gene expression was negatively correlated with mir-181a-5p expression. In addition, GTSE1 was positively correlated with CD274, PDCD1, and CTLA4 immune checkpoints. The mir-181a-5p is a target miRNA of GTSE1 and mir-181a-5p expression is positively correlated with patient survival.
Coupling relationship between financial inclusion and agricultural green total factor productivity: Mechanism analysis and empirical research
Authors: Liu Guibo , Liang Chenglei , Gong Xiaoxian
Published: June 2022

Based on the panel data of 30 provinces in China from 2006 to 2019, this paper measures the coupling coordination degree of financial inclusion and agricultural green total factor productivity (AGTFP), and uses Dagum Gini coefficient and spatial feature analysis method to study the regional difference and spatial agglomeration state of coupling coordination degree. On this basis, it further discusses the impact of the improvement of the coupling co scheduling of financial inclusion and AGTFP on the urban-rural income gap. The results show that the overall level of financial inclusion and AGTFP is low, but both show a slow upward trend, and the degree of coupling and coordination between the two continues to improve, which has developed from the very low coordination stage to the primary coordination stage. The two show the characteristics of alternating changes of the relative lag of AGTFP and the relative lag of financial inclusion. At present, the main performance is the relative lag of financial inclusion. There are great regional differences in the coupling coordination degree of financial inclusion and AGTFP, but this regional difference is gradually narrowing; And its spatial pattern presents the characteristics of global positive autocorrelation and local spatial pattern evolution. Further discussion found that the improvement of the coupling and co scheduling of financial inclusion and AGTFP is conducive to narrowing the income gap between urban and rural areas. Therefore, in order to realize the sustainable development of agriculture, it is suggested to coordinate the relationship between financial inclusion and AGTFP.
Influence of temperature on fouling removal for pipeline based on eco-friendly ultrasonic guided wave technology
Authors: Huang Mingkun , Han Cong , An Yang , Qu Zhigang , Chen Chuanxian , Yin Wuliang
Published: June 2022

When industrial pipelines are used to transport production materials, the scale can easily form on the inner wall of a pipeline due to long-term contact with the liquid medium. Scaling in industrial pipelines is a common problem that poses a great threat to the production process and environmental protection. In this paper, the influence of temperature on the fouling removal process in pipes is studied. A finite element simulation model was established for guided wave propagation in pipes with different temperatures to obtain the acoustic pressure distribution along the pipes, showing that when the temperature increases, the acoustic pressure value on the solid-liquid surface of the pipes increases, and the cavitation threshold decreases. The experimental system for pipe descaling at different temperatures was established, when the temperature is from 20°C to 60°C, the descaling rate in the inner wall of the pipe far from the transducer is increased from 77.49–93.71%, the descaling rate in the inner wall of the pipe near the transducer is increased from 87.01–97.02%. The experimental results showed that the descaling performance is better when the pipeline temperature is higher.
Ultrafine Fully Vulcanized Natural Rubber Modified by Graft-Copolymerization with Styrene and Acrylonitrile Monomers
Authors: Longsiri Krittaphorn , Mora Phattarin , Peeksuntiye Watcharapong , Jubsilp Chanchira , Hemvichian Kasinee , Karagiannidis Panagiotis , Rimdusit Sarawut
Published: June 2022

This research aims to modify ultrafine fully vulcanized powdered natural rubber (UFPNR) prepared by emulsion graft-copolymerization with styrene (St) and acrylonitrile (AN) monomers onto deproteinized natural rubber (DPNR). The effects of monomer content and St/AN weight ratio on grafting efficiency and thermal stability of the developed DPNR-g-(PS-co-PAN) were investigated. The results showed that grafting efficiency was enhanced up to 87% with weight ratio St:AN 80:20. The obtained DPNR-g-(PS-co-PAN) was radiated by an electron beam at various doses, followed by a spray drying process to produce UFPNR. The obtained modified UFPNR particles irradiated at dose up to 300 kGy were relatively spherical with a particle size of approximately 4.4 µm. Furthermore, the degradation temperature of 5wt% loss (Td5) of UFPNR was found in the range of 349–356°C. The results revealed that the modified UFPNR is suitable as a toughening filler for a broader spectrum of polymers.
The Compilation and Analysis of the 2015 Input-output Table of Kyoto Prefecture for the Cultural Industry
Authors: Zhang Heming , Ishiro Taku
Published: June 2022

The rise of cultural industry is in the part facilitated by the rise of leisure and entertainment in the advanced industrialized economies. Recently western countries have been attaching importance to cultural industry and developing it as one of the growth strategies. Japan has also made numerous efforts to its cultural industry. Kyoto prefecture, as the ancient capital of Japan, is famous for its traditional culture, promoting the development of its cultural industry positively in these years. This paper is to analyze the impact and development status of Kyoto’s cultural industry, based on the compilation of the 2015 Input-output table of Kyoto prefecture with 110 sectors. First, the writer modified the 2015 IO table of Kyoto prefecture with 105 sectors to 110 sectors IO table. Second, some important IO analysis indexes derived from the matrix such as specialization coefficient, influence coefficient and sensitivity coefficient to show the characteristics of Kyoto’s cultural industry. Third, the writer compares the model of endogenization of consumption expenditure of household with the basic model of equivalence of the outputs, in order to analyze the impact on the more complex economic circle of cultural industry.