bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation Of Compression Garment Compliance Factors İn Breast Cancer Patients
Authors: Keskin Kavak Songül , Aktekin Lale
Published: December 2024

Aim: Complete decongestive therapy (CDT) is the standard treatment of postmastectomy lymphedema. Our study aimed to determine the factors that impair compliance with the compression garment, one of the main phases of CDT, and to reduce the limiting effects of lymphedema by increasing the treatment compliance of lymphedema patients.
Material and Methods: In this prospective study, demographic and clinical information of the patients were recorded. The stage of lymphedema (International Society of Lymphology (ISL)) and whether they had received lymphedema treatment before were questioned. The experience of pressure garment use was evaluated with a 5-point Likert-type scale questionnaire covering factors affecting patient compliance.
Results: The mean age of 71 postmastectomy lymphedema patients was 56.3±8.6 years. 29 patients (40.8%) used their compression garments regularly every day, while 42 (59.1%) patients did not use them regularly. Regarding the mean score values, the top 3 reasons for limiting factors impairing compliance with the pressure garment were as follows: the patients had the most problems putting on and taking off the garment (3.94±1.30), had difficulty in housework in daily life (3.92±1.36), and had difficulty in participating in sports and hobby activities (3.84±1.41).
Conclusion: Patients' specific characteristics, lifestyle, and history are important in the selection of compression garments. It is important to identify factors that impair compliance with the compression garment, to inform patients about lymphedema preventive measures, and to enable them to better adapt to daily life with the compression garment may improve self-treatment management and reduce the need for caregivers
Attitudes towards cancer of parents admitted to the emergency department with a sick child: A Cross-sectional study
Authors: Şimşek Ayşegül , Günerigök Ferhat , Varkal Muhammet Ali
Published: December 2024

Aim: Parents' perspectives change when it comes to illnesses such as cancer. Parents find it stressful, especially given what
society thinks and believes. The aim of this study is to determine how parents with a sick child feel about cancer.
Material and Methods: The descriptive and cross-sectional study was completed with parents who presented to the pediatric emergency department of a hospital. The Measuring Attitudes Towards Cancer Questionnaire—Society Version and the Sociodemographic Information Form for parents and their children were used to gather the information. Scores of 2.5 and above indicate negative attitudes towards cancer. The statistical program was used to analyze the gathered information.
Results: The study was completed with 83 parents. There was no family history of cancer in 84.3% of them. The overall score for "the scale was found to be 3.2 points. In addition, 3.1 points were obtained from the impossibility of healing, 3.4 from the discrimination sub-dimension, and 3.1 from the cancer diagnosis and spread sub-dimension. A statistically significant difference was found between the total and all sub-dimensions of the scale and the number of previous hospitalizations, maternal age, paternal age, and maternal employment status (p
Clinical and Histopathological Effects of Isotretinoin on Neuroregeneration in Experimental Spinal Cord Injury
Authors: Şensoy Doğan , Polat Ömer , Kılıç Güven , Yakupoğlu Muammer , Karacor Kayihan
Published: December 2024

Aim: Spinal cord injury is an important problem, and a fully effective treatment for it has not yet been developed. Isotretinoin is a retinoid known for its anti-inflammatory effect. The present study aimed to evaluate whether isotretinoin has a positive impact on neural tissue in post-injury damage.
Material and Methods: A total of 36 rats were randomly divided into 6 groups as control, sham, and injury with 14-day 7.5 mg/kg/day, 28-day 7.5 mg/kg/day, 14-day 15 mg/kg/day, and 28-day 15 mg/kg/day isotretinoin groups. Laminectomy was performed and spinal cord injury was produced by using the clip compression technique. Neurological examination was performed on days 1, 7, 14, and 28. After the treatment period, all rats were sacrificed, and their spinal cord samples were collected for histopathological assessment.
Results: Groups receiving 7.5 mg/kg/day (p=0.048) and 15 mg/kg/day (p
Evaluation of the Reliability and Quality of YouTube Videos about Insulin Injection in Children
Authors: Turhan Banu
Published: December 2024

Aim: Social media platforms, especially YouTube, have become indispensable channels where patients apply for information on medical issues. This study aimed to evaluate the reliability and quality of videos on YouTube about insulin injection in children.
Material and Methods: The first 100 videos with the search “insulin injection in children” were analyzed. The distribution of video types, viewing rates, like ratios, number of comments, and video power indexes (VPI) were recorded. The content qualities were assessed by the global quality scale (GQS), modified DISCERN score, the Journal of the American Medical Association (JAMA) benchmark score, and the patient education materials assessment tool for audio/visual (PEMAT-A/V) materials.
Results: Forty-seven (47%) videos were analyzed finally. The median score of the GQS was 4, modified DISCERN and JAMA was 3. The median PEMAT A/V understandability and actionability scores were 84 and 75. Videos by professionals were found to have better results than the non-professional (p
Solar energy utilization and conservation in an industrial solar drying process
Authors: Elizabeth Cortés Rodríguez , Araceli Ruiz Mercado Claudia
Published: December 2024

Decarbonization in food production systems is one of the greatest challenges today. Solar drying is one of the processes that can help this energy transition and improve food production systems. This research presents the results of the development of a new solar drying technology with applicability in the food production system. A technoeconomic assessment was carried out. The best configuration for an integral drying system for various applications was obtained. The developed solar drying technology is portable, efficient, modular, versatile, continuous processing, with minimal degradation in the dehydrated product. According to the annualized cost method calculations, the cost of drying products with this technology is much lower than when using conventional energies and has a short payback period of 1–2 years. This research is the first part of the ongoing project. Improved equipment and various applications are in progress.
Ciało kontrolowane, ciało wyzwolone – o społecznych oczekiwania wobec kobiet na podstawie Siostrzeństwa świętej sauny
Authors: Garncarek Emilia
Published: December 2024

Artykuł jest próbą odpowiedzi na pytanie o „kinowe odzwierciedlenia” wpływu kultury patriarchalnej na doświadczanie kobiecości, w tym cielesności i seksualności. Tekst prezentuje wyniki jakościowej analizy wybranego obrazu filmowego pt. Siostrzeństwo świętej sauny w reżyserii Anny Hints. Jego twórczyni podjęła kwestię intymnych doświadczeń i zwierzeń grupy estońskich kobiet, które opowiadają o formatujących je wydarzeniach, w których ich ciała grały główną rolę. Podstawę teoretyczną zrealizowanego badania stanowiło podejście genderowe w badaniach społecznych oraz wybrane koncepcje cielesności.
Association of rs3755319 and rs4148325 of the UGT1A1 gene, rs2328136 of the NUP153-AS gene, and rs16928809 of the SLC22A18 gene with benign unconjugated hyperbilirubinemia
Authors: Ivanova Anastasiya A. , Apartseva Natalia E. , Kashirina Anastasiia P. , Nemcova Elena G. , Ivanova Julija V. , Kruchinina Margarita V. , Kurilovich Svetlana A. , Maksimov Vladimir N.
Published: December 2024

Background: Benign unconjugated hyperbilirubinemia, also known as Gilbert's syndrome, is a common in the population moderate increase in total and unconjugated bilirubin concentrations in individuals without liver disease or hemolysis.
Aim: To identify associations of rs3755319, rs4148325 of the UGT1A1 gene, rs2328136 of the NUP153-AS gene, and rs16928809 of the SLC22A18 gene with benign unconjugated hyperbilirubinemia.
Methods: This case-control study included a group of individuals with benign unconjugated hyperbilirubinemia (n = 414, mean age 36.7 ± 15.9 years, 49.8% men) and a control group (n = 381, mean age 39.1 ± 15.9 years, 52.5% men). The sample was randomly selected from the participants of the MONICA project, screening of young people aged 25–44 years and a cross-sectional study of schoolchildren in Novosibirsk. DNA was isolated from venous blood by phenol-chloroform extraction or an express assay (PROBA-RAPID-GENETICS, DNA-Technology, Russia). Genotyping of the groups by rs3755319, rs4148325 of the UGT1A1 gene, rs2328136 of the NUP153-AS gene, and rs16928809 of the SLC22A18 gene was performed by polymerase chain reaction followed by restriction fragment length polymorphism analysis.
Results: No significant differences were found between the individuals with benign unconjugated hyperbilirubinemia and the control group by the genotypes and alleles of the nucleotide sequence variants of rs16928809 of the SLC22A18 gene (p 0.05). The CC genotype and the C allele of rs3755319 of the UGT1A1 gene were more common in the individuals with benign unconjugated hyperbilirubinemia, than in the control group (CC vs AC + AA: odds ratio (OR) = 21.1, 95% confidence interval (CI) 14.7–30.4, p 0.001; C vs A: OR = 12.4, 95% CI 9.4–16.4, p 0.001). The concentrations of total and unconjugated bilirubin were higher in the carriers of the CC genotype of rs3755319, compared to the carriers of the other two genotypes (p 0.05). rs4148325 of the UGT1A1 gene was in the linkage disequilibrium with the rs3064744 UGT1A1 variant. The GG genotype and the G allele rs2328136 of the NUP153-AS gene were more common in the individuals with benign unconjugated hyperbilirubinemia than in the control group (GG vs AG + AA: OR = 1.361, 95% CI 1.002–1.848, p = 0.048; G vs A: OR = 1.33, 95% CI 1.02–1.73, p = 0.034).
Conclusion: The CC genotype and the C allele of rs3755319 of the UGT1A1 gene, the GG genotype and the G allele of rs2328136 of the NUP153-AS gene are the genotypes and alleles of risk for benign unconjugated hyperbilirubinemia. The rs16928809 of the SLC22A18 gene is not associated with benign unconjugated hyperbilirubinemia.
Piyano Alanında Deşifre Konusunda Yazılmış Araştırmalar: Bir Tematik İçerik Analizi
Authors: Gedik Gizem , Jelen Birsen
Published: December 2024

Türkiye’de piyano alanında deşifre konusunda yapılmış araştırmaların incelenmesini amaçlayan bu çalışmada, 2000-2023 yılları arasında tamamlanmış olan sekiz yüksek lisans tezi, dört doktora tezi ve 22 makale olmak üzere toplam 26 araştırma farklı değişkenler açısından incelenmiştir. Araştırmanın örneklemi, YÖK Tez Dokümantasyon Merkezi’ne kayıtlı ve erişimi izinli lisansüstü tezlerle ve google akademik, dergipark, WOS, ERIC arama motorlarında taranan araştırmalarla sınırlı tutulmuştur. İlgili araştırmalar; türleri, yılları, konuları, araştırma yöntemleri, veri toplama araçları, örneklem sayıları, veri analiz yöntemleri, sonuçları ve önerileri bakımından incelenmiştir. Araştırma, nitel bir araştırma olup verilerin toplanmasında doküman analizi kullanılmıştır. Tematik analiz yöntemi ilgili araştırmaların incelenmesi ve bu çalışmaların bulguları doğrultusunda genel durumun ortaya konması amaçlanmıştır. Verilerin çözümlenmesinde frekans (f) ve betimsel istatistikten yararlanılmış, sonuçlar tablo ve şekillerle gösterilmiştir. Araştırmanın sonucunda makale oranının lisansüstü çalışmalara kıyasla daha yüksek, en fazla çalışmanın 11-20 arası örneklem sayısında, en fazla kullanılan araştırma yönteminin nicel araştırma, en fazla kullanılan veri toplama aracının ölçek olduğu, en fazla kullanılan veri analizinin nicel analiz yöntemlerine ait non-parametrik testler, araştırma konularının yedi alt başlık, önerilerin ise toplam 11 alt başlık altında toplandığı görülmüştür.
Ön Lisans Bilgisayar Bölümü Öğrencilerinin Programlama Kaygılarının Çeşitli Değişkenler Açısından İncelenmesi
Authors: Keskinkılıç Fatma , Kalelioğlu Filiz
Published: December 2024

Programlama becerilerinin kazanılması, teknolojinin hızlı değiştiği ve dönüştüğü dijital çağda gittikçe önemli bir konu haline gelmiştir. Sadece bilgisayar bilimi alanında değil birçok alanda programlama becerilerine sahip iş gücüne ihtiyaç duyulmaktadır. Üniversitelerin farklı bölümlerinde programlama giriş dersleri bulunmaktadır. Fakat yapılan araştırmalar öğrencilerin programlama öğrenirken bazı zorluklarla karşılaştıklarını bildirmektedir. Bu zorluklar arasında programlama kaygısının öne çıktığı görülmektedir. Bu araştırmada, ön lisans bilgisayar bölümü öğrencilerinin programlamaya karşı kaygı durumları cinsiyet, öğrenim gördükleri program ve sınıf düzeyi değişkenlerine göre incelenmiştir. Betimsel araştırma modeline göre desenlenen araştırmada veriler, “Programlama Kaygı Ölçeği” ve yarı yapılandırılmış görüşme formu aracılığıyla toplanmıştır. Verilerin analizinde betimsel istatistikler, bağımsız örneklem t-testi kullanılmıştır. Araştırma sonucunda bilgisayar bölümü öğrencilerinin programlama kaygılarının çok yüksek olmadığı görülmüştür. Ayrıca öğrencilerin programlama kaygılarının cinsiyete, sınıf düzeyine göre farklılaştığı, programa göre fark olmadığı sonucuna ulaşılmıştır. Kadın öğrencilerin programlama kaygılarının erkek öğrencilerden, 2. sınıf öğrencilerinin ise programlama kaygılarının 1. sınıf öğrencilerden yüksek olduğu görülmüştür. Ayrıca araştırmanın nitel verilerine göre öğrencilerin programlama kaygısını azaltan faktörler “öğrenme ortamına ilişkin faktörler”, “kişiye özgü faktörler” ve “programlamaya ilişkin faktörler” olmak üzere gruplanmıştır.
Deos spernere. Lorsque les dieux romains vengent le mépris de leurs auspices et de leur puissance
Authors: Berthelet Yann
Published: December 2024

Afin de mettre en lumière les tensions qui traversent, entre vérité et mensonge, le formalisme des auspices romains, cet article revient sur plusieurs épisodes républicains de mépris des dieux et de leurs auspices, y compris les dira(e)-auspicia «oblatifs» annoncés dans le cadre d’une obnuntiatio : en particulier, par le pullaire du consul Papirius, en 293 avant notre ère ; par Fla­minius au début de son second consulat, en 217 avant notre ère ; et par Ateius Capito et Crassus, en 55 avant notre ère.
SOSYAL MEDYADA SAVAŞIN İZLERİNİN SUNUMU: SAVAŞ PORNOGRAFİSİ
Authors: Günay Yavuz Uğur , Ceylani Mehmet Uluç
Published: December 2024

İcadından kısa süre sonra Kırım Savaşı ile savaşların fotoğraflanmasına başlanmış, belge niteliği ve insanlar üzerindeki etkisi sayesinde propaganda amacıyla kullanma girişimleri, her zaman yaşanmıştır. Çağın getirdiği teknolojik gelişmeler ve toplumsal değişimler fotoğrafı ve fotoğrafa bakışı değişime uğratmıştır. Bugün gelinen noktada sosyal medya ve bu mecrada savaş görüntülerinin pornografik boyuta getirilmesi de bu değişimlerin sonucudur. Savaş fotoğrafları son derece etkisi yüksek görsellerdir. Günümüzde sosyal medya aracılığı ile fotoğrafçı ve izleyici perspektifi bakımından sınırsız müdahalelere uygun hale gelmiştir. Araştırma, bu bağlamdan yola çıkarak savaş fotoğrafçılığının evrildiği nokta olan savaş pornografisi eylemlerinin sosyal medya ile birlikte gelmiş olduğu noktayı Susan Sontag ve Jean Baudrilard’ın tespitleri ekseninde ortaya koymayı amaçlamıştır. Konuya dair yapılan alan yazın araştırması sonrasında örneklem olarak seçilen Ukrayna-Rusya ve İsrail-Filistin arasında süregelen savaş görüntülerinden pornografik olarak nitelendirilebilecek, Twitter yeni adıyla X platformu üzerinden yapılan paylaşımlar incelenmiştir. Görülmektedir ki günümüzde sosyal medya platformlarında yapılan savaşa dair paylaşımlarda siyasetçiler, taraftarlarının sayısını, medya profesyonelleri reytinglerini arttırmak, sosyal medya kullanıcıları ise daha çok beğeni alma, takipçi kazanma gibi beklentileri ile savaşın pornografik görüntülerini çekmekte, var olan görüntülerden yararlanarak videolar hazırlamakta ve paylaşmaktadır. Başkalarının trajedileri, acıları üzerinden kişisel çıkar ve tatmin sağlama çabası sonucunda yapılan paylaşımlar ile toplumda şiddet görüntülerine yabancılaşma ve normalleştirme gibi sonuçları olduğu görülmüştür.
A REVIEW OF THE VISUAL COMMUNICATION DESIGNS OF DOODLES CREATED BY GOOGLE FOR TÜRKİYE
Authors: Yıldız İbrahim , Uğur Engin
Published: December 2024

Google Doodles, which are brief, playful, and spontaneous alterations to the Google logo, have emerged as a globally recognized visual communication phenomenon. These Doodles are incorporated into the Google logo and serve as visual communication elements designed to infuse the search engine’s users with a sense of joy and celebration on special days, events, and other noteworthy occasions. From a visual communication design perspective, Google Doodles aim to convey a unique and meaningful message to their users. Although they are commonly referred to as Google Doodles, these designs, which are primarily illustrations, adhere to the tenets of visual communication design. A review of the literature reveals that no study has been conducted on Google Doodle designs in terms of visual communication design. This article is a unique contribution to the field, as it addresses a gap in the literature by conducting a study on visual communication design. The primary objective of this study is to evaluate the doodle examples designed by Google for Türkiye in terms of their visual communication design performance. A descriptive analysis of the Google Doodles created for Türkiye was conducted through a document analysis method. The findings indicated that the doodles were successful in terms of visual communication design, but there were significant deficiencies in reflecting the characteristic features of the people depicted in the doodles.
SAVAŞIN GÖRÜNEN YÜZÜ OLARAK ASKERİ KAMUFLAJIN SANATTA DEĞİŞEN ANLAMI
Authors: Akdemir İrem , Korkmaz F. Deniz
Published: December 2024

Bu çalışmada, askeri kamuflajın savaş meydanlarında oluşturduğu göz aldatmacasının ötesinde, bir sanat formuna nasıl dönüştüğü ve savaş sonrası dönemde sanat pratiklerinde nasıl kavramsal bir ifade biçimi haline geldiği incelenmiştir. Askeri kamuflaj, başlangıçta askeri personeli ve ekipmanı korumak için görsel bir taktik olarak geliştirilmiştir. Sanatçılar, dünya savaşları sırasında, nesnelerin çevre ile uyum sağlayarak yanılsama oluşturabilmesi için renk ve desen bilgilerini kullanmış ve gelişiminde önemli bir rol oynamıştır. Kamuflajın modern sanat akımları ile olan etkileşimi de militarizm ve kültürel dinamikler arasındaki ilişkisini pekiştirmiştir. 1960’lardan itibaren sanatta gizleme, yanılsama ve illüzyon etkilerinden yararlanılan bir ifade biçimine dönüşmüştür. Çalışmada, askeri kamuflaj kullanılarak üretilen güncel sanat eserleri araştırılmıştır. Bu kapsamda, askeri kamuflajın ilişkilendirildiği kavramlar sorgulanmış, eserlerin bağlamı ve içerdiği mesajlar betimsel analiz yöntemi ile çözümlenmeye çalışılmıştır. Ele alınan eserlerde, savaşın görünen yüzü olarak bilinen askeri kamuflajın savaşın görünmeyen yüzüne ait acıyı, güç ve şiddet unsurlarını, travma ve kayıpları yansıtan sembolik bir unsur olduğu sonucuna varılmıştır.
YENİDEN İŞLEVLENDİRME KAPSAMINDA İSMAİL DALGIÇ KONAĞI
Authors: Yavuz Öden Hülya
Published: December 2024

Tarihi alanlar içinde sürdürülebilirliğin sağlanması kentler için önemli bir olgu olmakla birlikte, bu yapılara uygulanacak koruma kurallarına uygun yaklaşımlar ile yapılar özgün değerlerini devam ettirebilmektedir. Çalışmanın örneklem alanını oluşturan yapı olan İsmail Dalgıç Konağı; Söke ilçesinde Kemalpaşa Mahallesinde yer almaktadır. Çalışmanın amacı, Kemalpaşa Mahallesinde yer alan tarihi yapıların restorasyonu ve yeniden işlevlendirilmesi ile tarihi yapıların özelliklerine göre müdahalelerin ve işlev değişikliklerinin mimari ve kültürel uyumluluğuna dikkat çekmek, konu ile ilgili yeni araştırmalara ışık tutabilmektir. Çalışma kapsamında bu yapının seçilmesinin nedeni yeni işlevi ile farklı kullanım amaçlarına hizmet etmeye başlayan yapının kent ile kültürel anlamda ilişkisini
belgelemektir. Bu bağlamda “İsmail Dalgıç Konağı” yapısının çalışma kapsamında incelenmesinde temel neden, yapının konut işlevinden farklı işleve dönüştürülmüş olmasıdır. Yöntem olarak nitel araştırma yöntemi kullanılarak veriler; gözlem, doküman analizi, yerinde belgeleme ile toplanmış, elde edilen bilgiler ışığında yapının günümüz kullanımına ilişkin kültürel anlamda katkıları ile ilgili bulgular oluşturulmuştur. Kat planlarının yeni işlev ile kullanımı ve restorasyon raporları incelenmiştir. Tarihi yapının mekânsal özelliklerinin az müdahale uygulanarak yeni işleve uyum sağladığı, Kemalpaşa Mahallesinde restore edilen diğer yapılarla birlikte kent kimliğine kazandırıldığı görülmüştür. Buradan hareketle yapının değişimi incelendiğinde ise, yapısal özelliklerin günümüze taşındığı, güncel ihtiyaçları karşılayabilen fonksiyonlar yönünde değişiminin olumlu sonuçlar getirdiği sonucuna varılmıştır.
DEVİSE TİYATRO VE BİR ÖRNEK OLARAK THE WOOSTER GROUP
Authors: Çelikçapa Özinan Ece
Published: December 2024

II. Dünya Savaşı sonrası İngiltere ve Amerika’da sıklıkla uygulandığı gözlemlenen Devise tiyatronun, bu anlayışla çalışan tiyatro gruplarına sanatsal üretim konusunda özgürlük sağladığı görülmektedir. Anlayışın uygulanmaya başlanması ile ilgili kesin bir dönem bulunmamakla birlikte, günümüzde popülerleşen bir çalışma yöntemi olmuş ve Türkiye’de de çeşitli tiyatro gruplarında uygulanmaya başlanmıştır. Bu çalışma yönteminin ilerleyiş biçiminin, tiyatro grubunu oluşturan ve reji, oyunculuk, tasarım, dramaturji gibi farklı alanlarda çalışan üyeler tarafından belirlendiği anlaşılmaktadır. Ancak yöntemi uygulayan tiyatro grupları açısından ortaklaşılan çıkış noktasının, çoğunlukla mevcut bir kurgusal hikaye seçilerek başlanması ve grup üyelerinin otobiyografik bilgileriyle harmanlanması
olduğu görülmektedir. Devise tiyatro anlayışıyla yapılan tiyatro çalışmalarında, kurgu ile gerçeğin bir araya getirilmesi değişkenlik göstermektedir. Uygulanış şekli tiyatro grupları arasında farklılık gösterdiği için, bu çalışmada pratik anlamda somutlaştırılması açısından The Wooster Group adlı tiyatro grubunun çalışmasına odaklanılmıştır. Bu makalede, Devise tiyatronun özellikleri üzerinde durulmuş ve tiyatroda uygulanışına yönelik özgün bir örnek olarak The Wooster Group hakkında bilgi verilmiş ve grubun Brace Up! adlı oyunu incelenmiştir.
Design and Development of Novel Herbal Suppository Formulation for Prostatitis Treatment
Authors: Golembiovska Olena , Dmytrenko Oleksandra , Galkin Alexander
Published: December 2024

Background. Prostatitis is a common inflammatory condition of the prostate gland, often treated with antibiotics and anti-inflammatory drugs, which may have limited efficacy and side effects. Herbal therapies offer a promising alternative due to their natural anti-inflammatory properties.
Objective. This study aims to design, develop, and evaluate physicochemical, biopharmaceutical and microbiological properties of novel herbal suppository formulations for the treatment of prostatitis, optimizing their biopharmaceutical profiles.
Methods. Excipients were selected to form suppositories with herbal ingredients known for their anti-inflammatory effects, specifically lovage, saw palmetto, and calendula CO2 extracts. The formulations were assessed based on key quality parameters, including organoleptic characteristics, average mass, melting point, deformation time, disintegration time, microbiological purity, and pH, ensuring compliance with European Pharmacopoeia (Ph. Eur.) standards. Biopharmaceutical studies compared the release profiles of active compounds from different suppository bases.
Results. Suppositories based on Witepsol® H15 exhibited satisfactory organoleptic properties, appropriate melting points, and acceptable deformation and disintegration times. The pH levels were within the required range, and microbiological tests confirmed purity. Biopharmaceutical evaluations showed that Witepsol® H15 suppositories had the most appropriate release rates of active compounds compared to those made with other bases. 
Conclusions. The novel herbal suppositories developed in this study show promise for managing prostatitis based on preliminary evaluations of their physicochemical, microbiological, and biopharmaceutical properties. Further clinical studies are required to confirm their efficacy and safety.
Cytodestructive Effects of Photodynamic Exposure in Primary Cultures of Malignant Glioma Cells
Authors: Rozumenko Volodymyr , Liubich Larysa , Staino Larysa , Egorova Diana , Dashchakovskyi Andrii , Malysheva Tatyana
Published: December 2024

Background. Photodynamic therapy (PDT) is a promising adjuvant method for the treatment of malignant gliomas (MG), including tumors with continued growth and tumor recurrences. For the clinical application of PDT, it is important to substantiate the effectiveness of the cytodestructive effect of the combined use of laser irradiation (LI) and photosensitizer (PS).
Objective. To evaluate the cytodestructive effects of photodynamic exposure with the use of PS chlorine E6 on primary MG cell cultures.
Methods. Primary cell cultures were obtained from samples of biopsy material from patients (n = 6) with a veri­fied diagnosis: 3 primary tumors (1 case of diffuse astrocytoma, NOS (G3), 1 – glioblastoma (GB), NOS (G4), 1 – gliosarcoma (G4)) and 3 – with continued tumor growth (1 – diffuse astrocytoma, NOS (G3), 1 – oligo­dendroglioma, NOS (G3) and 1 – GB, NOS (G4). Groups of cell cultures included: 1) control – cultured in a standard nutrient medium and experimental; 2) cultured with the addition of chlorine E6 (2.0 mg/ml);  3) cultivated without the addition of PS and subjected to LI; 4) cultivated with the addition of chlorine E6 and subsequent exposure to LI. After 24 h, morphological and morpho­metric studies were carried out.
Results. The primary MG cultures were characterized by different growth dynamics; mitotic activity of tumor cells varied from the highest rate in the culture of primary GB to lower values – in cultures of recurrent GB and primary astrocytoma and gliosarcoma, and the lowest – in cultures of continued growth of astrocytoma and oligodendroglioma after combined treatment. Direct exposure to chlorine E6 and LI reduced the total number of cells in the culture and their mitotic activity. The greatest cytodestructive effect was achieved with the combined effect of chlorine E6 and LI: the effective dose in the case of primary astrocytoma cells is 10 J/cm2 in pulse mode; for cells of primary GB and gliosarcoma, recurrent astrocytoma and oligodendro­glioma, the effective dose is 25 J/cm2 in pulsed mode. In the case of GB cells, continued growth, a dose of 25 J/cm2 is effective for both continuous and pulsed modes of LI.
Conclusions. Primary cell cultures of MG obtained directly from tumor tissue are an adequate model for evaluating the effectiveness of the cytodestructive effect of the combined use of LI and PS for PDT.
Bibliometric analysis of scientific research on repeat visit intention in tourism using visual mapping technique
Authors: DÍAZ-POMPA Félix , ERKOL BAYRAM Gül , VEGA-PÉREZ Beatriz , ERRANO-LEYVA Beatriz S , GÖK Hatice Sarı , BAYRAM Ali Turan
Published: December 2024

Purpose –The purpose of this study is to examine the status of scientific research on “revisit
intention” in the Scopus database through a systematic literature review using key indicators.
Methodology/Design/Approach – In this study, studies on revisit intention between 2007
and 2022 were analysed using bibliometric methods with the help of Rstudio.cloud
software. In this research, general information about the publications, citation analysis,
trend topic analysis, cross-country cooperation analysis, thematic analysis, and multiple
correspondence analysis were conducted.
Findings – Results, The sample of the study consists of 280 studies from 149 sources that
include “revisit intention” in the title, abstract and keywords of articles in journals scanned
in the Scopus database. It has been determined that there has been an increase in research
on the research topic in recent years, and the highest scientific production was published in
2022 with 76 research. The highest number of research on revisit intention was published
in the Sustainability journal (41 research), and China is the country with the most scientific
publications. The most productive author with 6 research on the research topic is Ramayah
Thurasamy. The strongest collaboration lines are those between China, Australia, Korea, the
United Kingdom and the United States. The topics that researchers mostly address regarding
revisit intention are destination image, service quality, perceived value, customer satisfaction,
and the effects of COVID-19. The research results provide a systematic and comprehensive
analysis of revisit intention and are thought to contribute to the field by describing the trends
and outlines of the subject to researchers who will examine this issue and to the tourism sector.
ACUMULAÇÃO DE MICROPARTÍCULAS DE POLIETILENO EM BRÂNQUIAS E ALTERAÇÕES HEMATOLÓGICAS DE TAMBATINGA (COLOSSOMA MACROPOMUM X PIARACTUS BRACKYPOMUS)
Authors: Do Carmo da Silva Ducilene , Rosa Martins Malba Geane , Rodrigues Ferreira Ericsson Rubens , Dos Santos Mariano Wagner , Estevan Moron Sandro , Gustavo Paulino Marcelo
Published: December 2024

Os microplásticos são micropartículas com tamanhos inferiores a 5 mm, considerados poluentes preocupantes ao ecossistema aquático, devido sua alta biodisponibilidade. O uso de microesferas de polietileno como ingrediente abrasivo, alerta para os efeitos nocivos que podem causar aos organismos aquáticos. O objetivo foi avaliar os efeitos de microesferas de polietileno em peixes tambatinga, quanto ao potencial de acumulação no órgão branquial e alterações morfofisiológicas após exposição aguda. Os peixes foram divididos (n =10) em um grupo controle e dois expostos (2 mg L-1 e 20 mg L-1 do microplástico), por 72 horas. Após a exposição, amostras de sangue e brânquias foram coletadas para análises hematológicas, morfológicas e de acúmulo. Foi observado acúmulo de microplásticos no órgão respiratório, na frequência de 30% (MP2) e 60% (MP20) que, potencialmente, poderia prejudicar sua funcionalidade normal. Não houve alteração nos parâmetros eritrocitários. Houve um aumento de neutrófilos e leucócitos granulares PAS-positivo nos grupos tratados, sugerindo uma possível infecção branquial decorrente da abrasão do microplástico. Não houve comprometimento da morfologia do tecido branquial. Logo, sugere-se que houve um aumento na produção de células mucosas, protegendo o tecido da abrasão com o MPs. As microesferas nas concentrações testadas poderiam apresentar toxicidade para peixes no ambiente natural.
LDL estimation with equations and machine learning; variance of LDL and plasma atherogenic index
Authors: Paplomatas Petros , Nikolidaki Marina , Vrahatis Aristidis , Anagnostopoulos Kostas
Published: December 2024

Cholesterol (CHOL), particularly low-density lipoprotein (LDL) CHOL, is responsible for many important diseases, including coronary artery disease, peripheral artery disease, and heart disease. In today’s modern society, this phenomenon has become a significant health issue for both adults and children, primarily due to dietary habits. LDL is a critical risk factor for atherosclerotic vascular disease or cardiovascular disease (CVD). However, the accurate determination of LDL is associated with high costs and technical difficulties such as ultracentrifugation. We present the LDLcalc package, which has two main functionalities: the first is the estimation of LDL from CHOL, high-density lipoprotein (HDL) CHOL, and triglycerides (TG). The second is the determination of the variance of LDL and atherogenic index of plasma (AIP), both of which are calculated clinical chemistry tests. LDL can be estimated using equations published in the literature or through machine learning (ML) methods. The package allows a comprehensive variety of approaches for estimating LDL values in patients, either through equations or through ten ML methods. When the direct measurement of LDL CHOL is not possible, equations or ML methods can be very good stand-ins. Additionally, the package provides the capability to calculate the variance of LDL and AIP using error propagation and bootstrap methods.
Dirac Fermion of a Monopole Pair (MP) Model of 4D Space-Time and Its Wider Implications
Authors: Yuguru Samuel
Published: December 2024

In quantum mechanics (QM), the electron of spin-charge, ±1/2 in probabilistic distribution about a nucleus of an atom is described by non-relativistic Schrödinger wave equation. Its transformation to Dirac fermion of a complex four-component spinor is incorporated into relativistic quantum field theory (QFT) based on Dirac theory. The link between QM and QFT on the basis of space-time structure remains lacking without the development of a proper, complete theory of quantum gravity. In this study, how a proposed MP model of 4D space-time mimicking hydrogen atom type is able to combine both QM and QFT into a proper perspective is explored. The electron of a point-particle and its transformation to Dirac fermion appears consistent with Dirac belt trick while sustaining unitarity of spin-charge and wave-particle duality with center of mass reference frame relevant to Newtonian gravity assigned to the point-boundary of the spherical model. Such a tool appears dynamic and is compatible with basic aspects of both QM and QFT such as non-relativistic wave function and its collapse, quantized Hamiltonian, Dirac theory, Weyl spinor, Marjorana fermions and Lorentz transformation. How all these relate to space-time curvature for an elliptical orbit without invoking a framework of space-time fabric is plotted for general relativity and a multiverse of the MP models at a hierarchy of scales is proposed for further investigations.
Dynamic Risks in Automotive Factories: Fire Risk in Lead-Acid Battery Manufacturing Process – 3D Simulations and Case Study
Authors: Zinveli Ankidim , Dragomir Mihai , Dragomir Diana
Published: December 2024

The present paper addresses dynamic risks in the automotive industry factories, specifically the car lead-acid batteries manufacturing area. The main analyzed risk is represented by the fire risk. Battery manufacturing process is described and analyzed from the fire risk perspective and the hazard areas are identified. The investigation methodology uses case studies for different lead-acid battery formation processes, combined with 3D simulations using PyroSym platform, and it is based on the author's experience in the battery manufacturing field for about ten years. The results of the case studies are compared using the same inputs, but different specific process conditions, and conclusions are formulated. To avoid the fires and mitigate the risk, a series of actions are proposed in the last sections. As a general conclusion, the actual research demonstrates that the complex and dynamic risks from the automotive industry, associated with Industry 5.0 must be analyzed using combined methods, classical and modern, including 3D simulations, to get great results.
Use of Light Emitting Diodes on the In Vitro Rooting of Apple Tree Rootstocks
Authors: Scolaro Adriana Maria Tomazini , De Martin Mariuccia Schlichting , Vieira Renato Luis , Schveitzer Bianca , de Souza Edson Luiz , Borges Endler Marcel
Published: December 2024

This study presents a novel investigation into the use of Light Emitting Diodes (LEDs) for the in vitro rooting of 'Marubakaido' apple tree rootstocks, marking the first time this approach has been reported in the literature. The research compares four different light sources: blue LED (450 nm), red LED (660 nm), a combination of red and blue LEDs, and traditional fluorescent lamps as a control. Mini-cuttings were inoculated in Murashige & Skoog (MS) medium with reduced nutrient concentrations and supplemented with indoleacetic acid (IAA) and sucrose. The explants were incubated under controlled conditions for 30 days, allowing for a thorough evaluation of the effects of different light sources on various growth metric. The study found that blue LEDs significantly increased dry mass accumulation seedlings compared to both red LEDs and fluorescent lamps, demonstrating the effectiveness of LEDs in promoting plant growth. Utilizing LEDs not only enhances seedling development but also offers economic benefits over fluorescent lamps. LEDs are known for their high luminous efficiency, low energy consumption, and long lifespan, which can lead to reduced operational costs in plant production systems. This research not only contributes to the understanding of light effects on plant tissue culture but also suggests that the combination of blue and red LEDs can serve as a viable alternative to fluorescent lamps, potentially transforming practices in the field of horticulture and plant propagation.
Combating Metallo-β-Lactamase-Producing Pseudomonas aeruginosa: The Fractional Inhibitory Concentration Index as a Tool to Evaluate Antibiotic Synergy
Authors: Granata Guido , Venditti Carolina , Rotondo Claudia , Dimartino Valentina , D'Arezzo Silvia , Gallo Assunta , Parisi Gabriella , Capone Alessandro , Fontana Carla , Cicalini Stefania
Published: December 2024

Background: Multi-drug-resistant Gram negative bacteria producing metallo-β-lactamase are an increasing concern. Here we describe three cases of infection due to difficult to treat resistant P. aeruginosa producing metallo-β-lactamases, successfully treated with antibiotic combination of cefiderocol plus imipenem-relebactam and report on the molecular and epidemiological features of the isolates and the in vitro synergistic effects of different antibiotic combinations to guide the antibiotic treatment.Patients and methods: Three P. aeruginosa strains were isolated from respiratory or blood cultures of three different patients. Minimum inhibitory concentrations breackpoints were interpreted according to EUCAST recommendations. Next Generation Sequencing data were used for in silico identifying resistance genes, sequence types and for core genome multi-locus sequence typing analysis. The fractional inhibitory concentration index was performed as a measure of synergy of cefiderocol plus imipenem and imipenem-relebactam. Results: The three isolates exhibited different multi-drug resistant and molecular profiles, carrying blaIMP-13 (isolates named Pse-1 and Pse-3) and blaVIM-2 carbapenemases (isolate Pse-2). Typing showed that the isolates did not cluster and belonged to different sequence types. The E-test method showed the presence of synergy of cefiderocol in combination with imipenem-relebactam in the two P. aeruginosa isolates producing IMP-13 (Pse-1 and Pse-3). No synergy was observed in the isolate producing VIM-2 (Pse-2). Conclusion: Cefiderocol in association with imipenem-relebactam exhibited a synergistic effect against IMP-producing P. aeruginosa isolates. Further studies with a range of drugs and an expanded number of isolates are required to ascertain potential novel synergistic associations and the clinical utility of the fractional inhibitory concentration index.
Dynamical Mechanisms on Multiple Recurvature of Re-Monsoonal Tropical Cyclone Mocha Over the Bay of Bengal
Authors: Pradhan P. K. , Kumar Sushant , Pandey Lokesh K , Desamsetti Srinivas , Thota S. Mohana , Ashrit Raghavendra
Published: December 2024

The Mocha cyclone, an extremely severe cyclonic storm (ESCS), moved unusually northeastwardly with a well-organized eyewall structure, underwent rapid intensification (RI), and then entered into coastal areas of Myanmar. It caused heavy rainfall (~90 mm) and gusty winds (~115knots ) over the coastal regions of BIMSTEC countries, such as the coasts of Bangladesh and Myanmar. The factors responsible for the RI of the cyclone in lower latitudes, such as SST, TCHP, vertical wind shear (VWS), and mid-tropospheric moisture transport, are studied using the National Ocean and Atmospheric Administration (NOAA) SST and National Centre for Medium Range Weather Forecasting (NCMRWF) Unified Global Model (NCUM) analysis. The results show that SST and TCHP values of 30℃ and 100 (KJcm-2) over BoB favored cyclogenesis. However, VWS (ms-1) and relative humidity (RH) within the range of 10 m/s and > 70% also provided a conducive environment for the cyclone to transform into the ESCS category. The physical mechanism of RI and recurvature of the Mocha cyclone have been investigated using forecast products and compared with CIRA and IMD satellite observations. Key results indicate that the dry air intrusion associated with a series of troughs and ridges at 500 hPa level due to the western disturbance (WD) during that time was very active over the northern part of India and adjoining Pakistan, which brought north-westerlies at 200hPa level. The Q-vector analysis and steering flow (SF) underscore that baroclinic instability plays a crucial role in allowing the Mocha cyclone to move in northeast directions, and it has been reasonably well represented by the NCUM model analysis and the 24-, 72-, and 120-hour forecast. Additionally, a quantitative assessment of the system indicates that the model forecasts of TC tracks have an error of 50, 70, and 100 km in 24-, 72-, and 120-hour lead times. Thus, the present case study underscores the strength of the NCUM model in representing the physical characteristics of the recurving and RI systems over BoB.
Exploring the Impact of University Environment on Student Depression: A Qualitative Study in Vietnam
Authors: Pham Viet Binh
Published: December 2024

This qualitative study investigates the influence of the university environment on depression among students in Vietnam, based on interviews with 100 students from various universities. Through thematic analysis, the research identifies key factors contributing to depression, including academic pressure, social relationship difficulties, and career-related anxiety. The findings reveal that a significant portion of students experience depressive symptoms, with academic pressure emerging as the most prominent factor. The study underscores the importance of enhancing psychological support and creating a more supportive educational environment to address these mental health challenges. By focusing on student experiences, this research provides valuable insights into the mental health landscape of university students in Vietnam.
A Guide to Using Safer Endemic Coronaviruses to Model the More Pathogenic Strains
Authors: Heffner Audrey L. , Rouault Tracey A.
Published: December 2024

In 2021, at the height of the COVID-19 pandemic, coronavirus research spiked with over 83,000 original research articles related to the word “coronavirus” added to the online resource pubmed. Just 2 years later in 2023, only 30,900 original research articles related to the word “coronavirus” were added. While, irrefutably, the funding of coronavirus research has drastically decreased, another possible argument for the decrease in interest in coronavirus research is that projects on SARS-CoV-2, the causative agent of COVID-19, halted due to the challenge of establishing a good cellular or animal model system. Most laboratories do not have the capabilities to ‘in house’ culture SARS-CoV-2 as it requires a Biosafety Level (BSL) 3 laboratory. Until recently, BSL 2 laboratory research on endemic coronaviruses was arduous due to the low cytopathic effect in isolated cell culture infection models and lack of means to quantify viral loads. The purpose of this review article is to compare the human coronaviruses and provide an assessment of the latest techniques that use the endemic coronaviruses—HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1—as lower biosafety risk models for the more pathogenic coronaviruses – SARS-CoV-2, SARS-CoV, and MERS-CoV.
Classification of Parotid Gland Neoplasms in Computed Tomography Images Using Convolutional Neural Networks
Authors: Chang Chan-Chi , Jiao Shen , Huang Zhih-Cheng , Horng Ming-Huwi
Published: December 2024

This study investigates the application of convolutional neural networks (CNNs) for the classification and segmentation of parotid tumors. The classification process involves two stages: first, isolating the region of the parotid gland, and second, classifying it into one of three categories—mixed, malignant, or Warthin tumors. The Yolov7 method achieved an AP50 of 0.964 for the initial stage. Additionally, the data-efficient image transformers (DEIT) method was employed to classify parotid gland computerized tomographic images into mixed, Warthin, or malignant tumor categories. The classification accuracies were 0.923 for distinguishing between tumor presence and absence, 0.947 for differentiating malignant tumors from mixed and Warthin tumors, and 0.844 for distinguishing malignant from mixed tumors. To enhance diagnostic accuracy across all computerized tomographic slices for each patient or healthy participant, a decision tree mechanism based on the DEIT model was developed, aggregating classification results from individual slices. Furthermore, U-Net, U-Net++, TransUNet, and Swin-Unet models were independently applied to segment tumor images. Among 2,961 tumor images tested, TransUNet demonstrated superior performance, achieving an average Dice similarity coefficient of 0.921. Experimental results indicate that the combined classification and segmentation approach achieves an overall classification accuracy of 0.904 and a Dice similarity coefficient of 0.921.
Tomato Stem and Leaf Segmentation and Extraction of Phenotypic Parameters Based on Improved Optimization Algorithm for Red-billed Blue Magpie
Authors: Zhang Lina , Huang Ziyi , Yang Bo , Yu Shengpeng , Zhao Shuai , Zhang Xingrui , Li Xinying , Yang Han , Lin Yixing , Yang Zhiyin , Yu Helong
Published: December 2024

In response to the structural changes of tomato seedlings, traditional image techniques are difficult to accurately quantify key morphological parameters, such as leaf area, internode length, and mutual occlusion between organs. Therefore, this paper proposes a tomato point cloud stem and leaf segmentation framework based on Elite Strategy-based Improved Red-billed Blue Magpie Optimization Algorithm (ES-RBMO). The framework uses a four-layer Convolutional Neural Network (CNN) for stem and leaf segmentation by combining an improved swarm intelligence algorithm with the values of precision, recall, F1 score, IoU and ACC of 0.965, 0.965, 0.965, 0.965, 0.965, 0.933, respectively.We analyzed the segmented organs, four key phenotypic parameters of the plants were extracted. The phenotypic parameters of plant height, stem thickness, leaf area and leaf inclination were analyzed by comparing the values extracted by manual measurements with the values extracted by the 3D point cloud technique. The results showed that the coefficients of determination (R²) for these parameters were 0.932, 0.741, 0.938 and 0.935, respectively, indicating high correlation. The root mean square error (RMSE) was 0.511, 0.135, 0.989 and 3.628, reflecting the level of error between the measured and extracted values. The absolute percentage errors (APE) were 1.970, 4.299, 4.365 and 5.531, which further quantified the measurement accuracy. In this study, an efficient and adaptive intelligent optimization framework was constructed, which is capable of optimizing data processing strategies to achieve efficient and accurate processing of tomato point cloud data. This study provides a new technical tool for plant phenotyping and helps to improve the intelligent management in agricultural production.