bluuebunny/crossref_metadata_2025 huggingface dataset:
Conceptualizing a Methodology for Cultural Heritage Futures: Using Futurist Hindsight to Make ‘Known Unknowns’ Knowable
Authors: Spennemann Dirk H. R.
Published: January 2023

In a broad conceptual framing, cultural heritage is the result of humankind’s interactions with their environment and one another, both in its tangible and intangible expressions. Cultural heritage management is by nature a retrospective discipline, as the assessment and evaluation of cultural significance of heritage assets requires the passage of time. Practitioners often struggle with the evaluation and management of very modern and contemporary heritage items. There is a need to examine whether current approaches and practices are fit for purpose. Current cultural heritage theory abounds with the concept of heritage stewardship with the embedded futurist stance that we should hand on our heritage in good shape to the next generation, yet all approaches are retrospective and rooted in the values of the present. This paper examines to what extent stewardship, as well as two other futurist concepts, the precautionary principle and strategic foresight, are suitable tools for heritage management. Based on that review, this paper then conceptualizes and proposes an assessment model that positions the valuer into a strategic foresight-derived, modelled future ‘reality’ at a 15 to 30-year horizon, which then allows the valuer to apply standard heritage hindsight assessment methodology to contemporary heritage items.
The Influence of Family Crisis Coping Strategies on Family Quality of Life in the Assessment of Patients with Idiopathic Scoliosis
Authors: Cyran-Grzebyk Barbara , Perenc Lidia , Wyszyńska Justyna , Kołodziej-Lackorzyńska Gabriela , Majewska Joanna
Published: January 2023

The aim of the study was to assess the impact of the strategies of coping with the family crisis in children and adolescents with idiopathic scoliosis on the level of their family’s quality of life (FQOL). The study group consisted of 100 adolescents (girls 83%, boys 17% of the entire main group) with an average age of 14 (13.83 ± 1.92). The control group consisted of the same number of people as the study group (girls 78%, boys 22% of the entire control group) with an average age of 14 (14.09 ± 2.16). The FQOL scale was used to assess the family’s quality of life, and the F-COPES scale was used to assess the problem-solving strategies used by the family (individual members) in a difficult life situation. Statistical analysis showed significant differences between the two compared groups. While dealing with a crisis situation in their families, adolescents treated for idiopathic scoliosis were using the spiritual support strategy (M ± SD 5.12 ± 2.07) significantly more often, while their healthy peers much more willingly and more often benefited from other possible strategies (F-COPES). Additionally, statistically significant differences were observed in the assessment of children and adolescents from both groups that the usage of different strategies available on the F-COPES scale correlated and affected the areas of the FQOL level of their families. Gaining spiritual support had a negative impact on the area of physical and financial well-being of FQOL, as assessed by juveniles with SI (R = −0.254, p = 0.011). However, in the opinion of healthy peers, the strategy of gaining social support (F-COPES) resulted in a higher level of FQOL in the area of disability problems (p = 0.005). A long process of SI treatment can cause crisis situations for patients and their families and affect both the physical and mental health of patients by changing the FQOL level of their families.
Effectiveness of Network Relations in Poland during the Economic Crisis Caused by COVID-19: Interorganizational Network Viewpoints
Authors: Sus Aleksandra , Organa Michał , Hołub-Iwan Joanna
Published: January 2023

The global pandemic triggered by the SARS-CoV-2 virus has caused marked changes in the economic landscape in essentially every branch of the economy. The pandemic has disordered lives across all countries in the world and also affected the public sector in interesting ways. Our empirical research, of which selected elements are presented in this paper, was conducted under pandemic conditions. This paper aims to identify the relationships between selected distinguishing features of the oncological interorganizational network (exchange, engagement, reciprocity) and determine their effectiveness under the conditions of the economic crisis caused by the COVID-19 pandemic. A side thread, which concludes the article, is the introduction of the category “economic virus” into management terminology; i.e., a set of factors causing economic crises with a microbiological genesis. Of particular importance are considerations regarding the uncertainty of the length and depth of the health crisis-related economic effects in financial markets and corporate decision making.
COVID-19 as an Occupational Disease—Temporal Trends in the Number and Severity of Claims in Germany
Authors: Nienhaus Albert , Stranzinger Johanna , Kozak Agnessa
Published: January 2023

COVID-19 is considered an occupational disease (OD), when infection occurs at the workplace for health workers (HW). Because of the increased infection risk of these workers, they were deemed to be a priority group when the vaccination campaign started in Germany in December 2020. By December 2021, more than 90% of HW had been vaccinated twice. We studied the number and the time trend concerning the severity of OD claims related to COVID-19. Workers’ compensation claims for OD are recorded in a standardized database of the Statutory Accident Insurance and Prevention in the Health and Welfare Services (BGW). We analyzed all notifiable COVID-19 related claims filed between 1 March 2020 and 30 September 2022. The proportion of severe cases was estimated by inpatient stays, injury benefit payments, rehabilitation measures, and deaths. The data analysis was descriptive. Due to COVID-19, 317,403 notifiable cases were reported to the BGW. Of these, 200,505 (63.2%) had thus far been recognized as OD. The number of notifiable cases was highest in 2022 and lowest in 2020. In total, 3289 insured individuals were admitted to rehabilitation management. This represented 1.6% of all recognized ODs due to COVID-19 at the BGW. The proportion of cases admitted to rehabilitation management decreased from 4.5% of all recognized ODs in 2020 to 3.2% in 2021 and to 0.1% of all recognized cases in 2022. For inpatient stays, injury benefit payment, and death, a similar trend was observed. Therefore, it might be concluded that the successful vaccination campaign mitigated the negative health effects of COVID-19 on HW. Even with vaccination, severe cases can occur. Therefore, infection prevention at the workplace remains paramount.
Quantifying the Spatiotemporal Heterogeneity of PM2.5 Pollution and Its Determinants in 273 Cities in China
Authors: Yang Li , Qin Chunyan , Li Ke , Deng Chuxiong , Liu Yaojun
Published: January 2023

Fine particulate matter (PM2.5) pollution brings great negative impacts to human health and social development. From the perspective of heterogeneity and the combination of national and urban analysis, this study aims to investigate the variation patterns of PM2.5 pollution and its determinants, using geographically and temporally weighted regression (GTWR) in 273 Chinese cities from 2015 to 2019. A comprehensive analytical framework was established, composed of 14 determinants from multi-dimensions, including population, economic development, technology, and natural conditions. The results indicated that: (1) PM2.5 pollution was most severe in winter and the least severe in summer, while the monthly, daily, and hourly variations showed “U”-shaped, pulse-shaped and “W”-shaped patterns; (2) Coastal cities in southeast China have better air quality than other cities, and the interaction between determinants enhanced the spatial disequilibrium of PM2.5 pollution; (3) The determinants showed significant heterogeneity on PM2.5 pollution—specifically, population density, trade openness, the secondary industry, and invention patents exhibited the strongest positive impacts on PM2.5 pollution in the North China Plain. Relative humidity, precipitation and per capita GDP were more effective in improving atmospheric quality in cities with serious PM2.5 pollution. Altitude and the proportion of built-up areas showed strong effects in western China. These findings will be conductive to formulating targeted and differentiated prevention strategies for regional air pollution control.
SOphrology Intervention to Improve WELL-Being in Hospital Staff (SO-WELL): Protocol for a Randomized Controlled Trial Study
Authors: Dutheil Frédéric , Parreira Lénise M. , Pereira Bruno , Baldet Maryse , Marson Frédérique , Chabaud Christine , Blot Magali , Baker Julien S. , Zak Marek , Vallet Guillaume , Magnon Valentin , Clinchamps Maëlys , Altun Senem
Published: January 2023

Introduction: Stress at work and psychosocial risks are a major public health problem. Sophrology and neurolinguistic programming (NLP) have demonstrated benefits in terms of mental, physical and social health, both in the general population and in patients, and both in and out of hospital settings. However, these approaches have never been provided at the hospital for the benefit of health professionals at risk of suffering at work. In general, we aim to demonstrate the effectiveness of a hospital sophrology/NLP intervention for health care professionals at risk of stress-related disorders. The secondary objectives are to study (i) within-group, and (ii) between-group): (1) effects on mental, physical, and social health; (2) persistence of effect; (3) relationships between job perception and mental, physical, and social health; (4) intervention success factors (personality and job perception, attendance and practice, other); (5) effects on other stress biomarkers (other measures of autonomic nervous system activity, DHEAS, cortisol, etc.). Methods: Our study will be a randomized controlled prospective study (research involving the human person of type 2). The study will be proposed to any health-care workers (HCW) or any non-HCW (NHCW) from a healthcare institution (such as CHU of Clermont-Ferrand, other hospitals, clinics, retirement homes). Participants will benefit from NLP and sophrology interventions at the hospital. For both groups: (i) heart rate variability, skin conductance and saliva biomarkers will be assessed once a week during the intervention period (6 to 8 sophrology sessions) and once by month for the rest of the time; (ii) the short questionnaire will be collected once a week during the whole protocol (1–2 min); (iii) the long questionnaire will be assessed only 5 times: at baseline (M0), month 1 (M1), month 3 (M3), month 5 (M5) and end of the protocol (M7). Ethics and dissemination: The protocol, information and consent form had received the favorable opinion from the Ethics Committee. Notification of the approval of the Ethics Committee was sent to the study sponsor and the competent authority (ANSM). The study is registered in ClinicalTrials.gov under the identification number NCT05425511 after the French Ethics Committee’s approval. The results will be reported according to the CONSORT guidelines. Strengths and limitations of this study: The psychological questionnaires in this study are self-assessed. It is also possible that responses suffer from variation. For the study, participants need to attend 6 to 8 sophrology sessions and one visit per month for 7 months, which might seem demanding. Therefore, to make sure that participants will complete the protocol, two persons will be fully in charge of the participants’ follow-up.
Over-the-Counter Medication Use among Parents in Saudi Arabia
Authors: Mirdad Ola A. , Esheba Ghada E. , Mousa Ahmed H. , Nukaly Houriah Y. , Alhindi Yosra Z. , Hariri Nahla H. , Ayoub Nahla , Alsanosi Safaa M.
Published: January 2023

Introduction: Self-medication is a growing public health concern worldwide. Studies have shown a gap between best practice and the current practice of using over-the-counter (OTC) medications. Despite being a well-recognised problem in Saudi Arabia, few studies have investigated OTC medication use in Saudi Arabia. Therefore, this study aimed to investigate the attitudes and knowledge of parents regarding OTC medication use in the Jeddah region, Saudi Arabia. Method: A cross-sectional study was carried out via an electronic questionnaire sent randomly to parents over four months, from 1 January to 30 April 2022. The participants’ characteristics and categorical variables were represented descriptively by frequency and percentage. A Chi-square test was used to test the relationship between the variables. Results: In total, 211 questionnaires were included in this study. Females represented 54.5% of the participants included in the study. Parents belonging to the 18-to-30-year-old group comprised the highest percentage (37.9%), and most of the parents (72.9%) had received an undergraduate education. Family physicians were the most common source (37.3%) of information about OTC medications, whereas more than half of parents purchased OTC medications from the community pharmacy (58.8%). While almost half of the parents (52.1%) visited a family physician when side effects of OTC medications appeared in their children, only (33.6%) stopped giving their children the OTC medicine. The relationship between the sociodemographic characteristics (including educational level, marital status, and employment status) and OTC drug consumption was significant (p < 0.001). Conclusion: Educational campaigns are needed to guide patients about the proper use of OTC medications. Studies on OTC medication use are lacking in Saudi Arabia in terms of its frequency, reasons for use, type of self-medication, and contributing factors.
How Do Ecological and Recreational Features of Waterfront Space Affect Its Vitality? Developing Coupling Coordination and Enhancing Waterfront Vitality
Authors: Chen Lihua , Ma Yuan
Published: January 2023

People are increasingly concerned with natural environment quality (NEQ) as well as recreation services (RS) as the popularity of natural experiences grows. Specifically, public spaces in ecologically sensitive areas must achieve coordinated eco-recreational development. Waterfront spaces fall into this category, providing a high-quality natural environment and facilitating various recreational activities. This paper uses two waterfront spaces, Foshan New City Riverfront Park and Nanhai Qiandeng Lake Park, as sample sites, divides 22 waterfront space samples into specific research objects, introduces dual variables for RS function and NEQ, and uses mathematical and statistical methods, such as Pearson correlation analysis, coupling coordination degree calculation, and redundancy analysis, to investigate the influence of different waterfront spaces on RS function and NEQ. Finally, we propose an optimization strategy for coupling and coordinating the development of the RS function and the NEQ of waterfront space. This paper found the following: (1) RS (number of public facilities) and natural environment quality (shoreline curvature) are the dominant factors in the vitality of waterfront space; (2) optimization of RS function will restrict the development of NEQ to a certain extent; and (3) the coupling and coordination of NEQ and RS function are positively related to the vitality of waterfront space. This study can be valuable for government officials and waterfront space planners as they develop social–ecological synergy models.
Quick on Your Feet: Modifying the Star Excursion Balance Test with a Cognitive Motor Response Time Task
Authors: Lowell Russell K. , Conner Nathan O. , Derby Hunter , Hill Christopher M. , Gillen Zachary M. , Burch Reuben , Knight Adam C. , Reneker Jennifer C. , Chander Harish
Published: January 2023

The Star Excursion Balance Test (SEBT) is a common assessment used across clinical and research settings to test dynamic standing balance. The primary measure of this test is maximal reaching distance performed by the non-stance limb. Response time (RT) is a critical cognitive component of dynamic balance control and the faster the RT, the better the postural control and recovery from a postural perturbation. However, the measure of RT has not been done in conjunction with SEBT, especially with musculoskeletal fatigue. The purpose of this study is to examine RT during a SEBT, creating a modified SEBT (mSEBT), with a secondary goal to examine the effects of muscular fatigue on RT during SEBT. Sixteen healthy young male and female adults [age: 20 ± 1 years; height: 169.48 ± 8.2 cm; weight: 67.93 ± 12.7 kg] performed the mSEBT in five directions for three trials, after which the same was repeated with a response time task using Blazepod™ with a random stimulus. Participants then performed a low-intensity musculoskeletal fatigue task and completed the above measures again. A 2 × 2 × 3 repeated measures ANOVA was performed to test for differences in mean response time across trials, fatigue states, and leg reach as within-subjects factors. All statistical analyses were conducted in JASP at an alpha level of 0.05. RT was significantly faster over the course of testing regardless of reach leg or fatigue state (p = 0.023). Trial 3 demonstrated significantly lower RT compared to Trial 1 (p = 0.021). No significant differences were found between fatigue states or leg reach. These results indicate that response times during the mSEBT with RT is a learned skill that can improve over time. Future research should include an extended familiarization period to remove learning effects and a greater fatigue state to test for differences in RT during the mSEBT.
Molecular Mechanisms of Noncoding RNA in the Occurrence of Castration-Resistant Prostate Cancer
Authors: Lin Yu , Tan Haisong , Yu Guopeng , Zhan Ming , Xu Bin
Published: January 2023

Although several therapeutic options have been shown to improve survival of most patients with prostate cancer, progression to castration-refractory state continues to present challenges in clinics and scientific research. As a highly heterogeneous disease entity, the mechanisms of castration-resistant prostate cancer (CRPC) are complicated and arise from multiple factors. Among them, noncoding RNAs (ncRNAs), the untranslated part of the human transcriptome, are closely related to almost all biological regulation, including tumor metabolisms, epigenetic modifications and immune escape, which has encouraged scientists to investigate their role in CRPC. In clinical practice, ncRNAs, especially miRNAs and lncRNAs, may function as potential biomarkers for diagnosis and prognosis of CRPC. Therefore, understanding the molecular biology of CRPC will help boost a shift in the treatment of CRPC patients. In this review, we summarize the recent findings of miRNAs and lncRNAs, discuss their potential functional mechanisms and highlight their clinical application prospects in CRPC.
Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells
Authors: Jacksi Mevan , Schad Eva , Buday László , Tantos Agnes
Published: January 2023

Tks4 is a large scaffold protein in the EGFR signal transduction pathway that is involved in several cellular processes, such as cellular motility, reactive oxygen species-dependent processes, and embryonic development. It is also implicated in a rare developmental disorder, Frank–ter Haar syndrome. Loss of Tks4 resulted in the induction of an EMT-like process, with increased motility and overexpression of EMT markers in colorectal carcinoma cells. In this work, we explored the broader effects of deletion of Tks4 on the gene expression pattern of HCT116 colorectal carcinoma cells by transcriptome sequencing of wild-type and Tks4 knockout (KO) cells. We identified several protein coding genes with altered mRNA levels in the Tks4 KO cell line, as well as a set of long non-coding RNAs, and confirmed these changes with quantitative PCR on a selected set of genes. Our results show a significant perturbation of gene expression upon the deletion of Tks4, suggesting the involvement of different signal transduction pathways over the well-known EGFR signaling.
Emerging Roles of Hedgehog Signaling in Cancer Immunity
Authors: Giammona Alessandro , Crivaro Enrica , Stecca Barbara
Published: January 2023

Hedgehog–GLI (HH) signaling plays an essential role in embryogenesis and tissue homeostasis. Aberrant activation of the pathway through mutations or other mechanisms is involved in the development and progression of numerous types of cancer, including basal cell carcinoma, medulloblastoma, melanoma, breast, prostate, hepatocellular and pancreatic carcinomas. Activation of HH signaling sustains proliferation, suppresses cell death signals, enhances invasion and metastasis, deregulates cellular metabolism and promotes angiogenesis and tumor inflammation. Targeted inhibition of the HH pathway has therefore emerged as an attractive therapeutic strategy for the treatment of a wide range of cancers. Currently, the Smoothened (SMO) receptor and the downstream GLI transcriptional factors have been investigated for the development of targeted drugs. Recent studies have revealed that the HH signaling is also involved in tumor immune evasion and poor responses to cancer immunotherapy. Here we focus on the effects of HH signaling on the major cellular components of the adaptive and innate immune systems, and we present recent discoveries elucidating how the immunosuppressive function of the HH pathway is engaged by cancer cells to prevent immune surveillance. In addition, we discuss the future prospect of therapeutic options combining the HH pathway and immune checkpoint inhibitors.
Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury
Authors: González-Lafuente Laura , Navarro-García José Alberto , Valero-Almazán Ángela , Rodríguez-Sánchez Elena , Vázquez-Sánchez Sara , Mercado-García Elisa , Pineros Patricia , Poveda Jonay , Fernández-Velasco María , Kuro-O Makoto , Ruilope Luis M. , Ruiz-Hurtado Gema
Published: January 2023

Acute kidney injury (AKI) is associated with an elevated risk of cardiovascular major events and mortality. The pathophysiological mechanisms underlying the complex cardiorenal network interaction remain unresolved. It is known that the presence of AKI and its evolution are significantly associated with an alteration in the anti-aging factor klotho expression. However, it is unknown whether a klotho deficiency might aggravate cardiac damage after AKI. We examined intracellular calcium (Ca2+) handling in native ventricular isolated cardiomyocytes from wild-type (+/+) and heterozygous hypomorphic mice for the klotho gene (+/kl) in which an overdose of folic acid was administered to induce AKI. Twenty-four hours after AKI induction, cardiomyocyte contraction was decreased in mice with the partial deletion of klotho expression (heterozygous hypomorphic klotho named +/kl). This was accompanied by alterations in Ca2+ transients during systole and an impairment of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) function in +/kl mice after AKI induction. Moreover, Ca2+ spark frequency and the incidence of Ca2+ pro-arrhythmic events were greater in cardiomyocytes from heterozygous hypomorphic klotho compared to wild-type mice after AKI. A decrease in klotho expression plays a role in cardiorenal damage aggravating cardiac Ca2+ mishandling after an AKI, providing the basis for future targeted approaches directed to control klotho expression as novel therapeutic strategies to reduce the cardiac burden that affects AKI patients.
Distribution and Organization of Descending Neurons in the Brain of Adult Helicoverpa armigera (Insecta)
Authors: Liu Xiaolan , Yang Shufang , Sun Longlong , Xie Guiying , Chen Wenbo , Liu Yang , Wang Guirong , Yin Xinming , Zhao Xincheng
Published: January 2023

The descending neurons (DNs) of insects connect the brain and thoracic ganglia and play a key role in controlling insect behaviors. Here, a comprehensive investigation of the distribution and organization of the DNs in the brain of Helicoverpa armigera (Hübner) was made by using backfilling from the neck connective combined with immunostaining techniques. The maximum number of DN somata labeled in H. armigera was about 980 in males and 840 in females, indicating a sexual difference in DNs. All somata of DNs in H. armigera were classified into six different clusters, and the cluster of DNd was only found in males. The processes of stained neurons in H. armigera were mainly found in the ventral central brain, including in the posterior slope, ventral lateral protocerebrum, lateral accessory lobe, antennal mechanosensory and motor center, gnathal ganglion and other small periesophageal neuropils. These results indicate that the posterior ventral part of the brain is vital for regulating locomotion in insects. These findings provide a detailed description of DNs in the brain that could contribute to investigations on the neural mechanism of moth behaviors.
A Comparison of Two Forward Head Posture Corrective Approaches in Elderly with Chronic Non-Specific Neck Pain: A Randomized Controlled Study
Authors: Suwaidi Aisha Salim Al , Moustafa Ibrahim M. , Kim Meeyoung , Oakley Paul A. , Harrison Deed E.
Published: January 2023

Forward head posture (FHP) is a common postural displacement that is significantly associated with neck pain, with higher risks of having neck pain in female and older populations. This study investigated the effect of two different forward head posture (FHP) interventions in elderly participants with poor posture and non-specific neck pain. Sixty-six elderly participants with a craniovertebral angle (CVA) < 50° were randomized into either a Chiropractic Biophyics® (CBP®) or a standardized exercise based FHP correction group (Standard Group). Both groups were treated for 18 sessions over a 6-week period. A 3-month post-treatment follow-up was also assessed with no further interventions. The CBP group received a mirror image® exercise and a Denneroll™ cervical traction orthotic (DCTO); the standard group performed a protocol of commonly used stretching and strengthening exercises for the neck. Both groups received 30 min of their respective interventions per session. The primary outcome was the CVA, with secondary outcomes including pain intensity, Berg balance score (BBS), head repositioning accuracy (HRA), and cervical range of motion (CROM). After 18 sessions (6 weeks later), the CBP group had statistically significant improvement in the CVA (p < 0.001), whereas the standard group did not. In contrast, both groups showed improved functional measurements on the BBS and HRA as well as improved pain intensity. However, at the 3-month follow-up (with no further treatment), there were statistically significant differences favoring the CBP group for all outcomes (p < 0.001). The differences in the between group outcomes at the 3-month follow-up indicated that the improved outcomes were maintained in the CBP group, while the standard group experienced regression of the initially improved outcomes at 6 weeks. It is suggested that the improvement in the postural CVA (in the CBP group but not in the standard group) is the driver of superior and maintained pain and functional outcomes.
Soluble Vascular Cell Adhesion Molecule-1 as an Inflammation-Related Biomarker of Coronary Slow Flow
Authors: Zhu Qing , Zhao Cuiting , Wang Yonghuai , Mu Lixin , Li Xinxin , Qi Yiqiu , Yang Jun , Ma Chunyan
Published: January 2023

Background: Coronary slow flow (CSF) is an angiographic entity characterized by delayed coronary opacification with no evident obstructive lesion in the epicardial coronary artery. Several studies have shown that the occurrence and development of CSF may be closely related to inflammation. Soluble vascular cell adhesion molecule-1 (sVCAM-1) is a biomarker related to inflammation. The aim of this study was to evaluate the correlation between plasma soluble VCAM-1 level and CSF occurrence and thus the predictive value of VCAM-1 for CSF. Methods: Forty-six CSF patients and thirty control subjects were enrolled. Corrected thrombolysis in myocardial infarction frame count (cTFC) was used to diagnose CSF. Functional status and quality of life were determined by the Seattle Angina Questionnaire (SAQ). Echocardiography was used to evaluate the systolic and diastolic function of the left ventricle (LV) and right ventricle (RV). The plasma levels of sVCAM-1, IL-6, and TNF-α were quantified by enzyme-linked immunosorbent assay. Results: Compared with the control group, the physical limitation score by the SAQ, the LV global longitudinal strain (GLS), mitral E, and mitral E/A decreased in patients with CSF, while the plasma IL-6 and TNF-α levels increased. The plasma sVCAM-1 level in the CSF group was significantly higher than that in the control group (186.03 ± 83.21 vs. 82.43 ± 42.12 ng/mL, p < 0.001), positively correlated with mean cTFC (r = 0.57, p < 0.001), and negatively correlated with the physical limitation score (r = −0.32, p = 0.004). Logistic regression analyses confirmed that plasma sVCAM-1 level (OR = 1.07, 95%CI: 1.03–1.11) is an independent predictor of CSF, and the receiver operating characteristic curve analysis showed that plasma sVCAM-1 levels had statistical significance in predicting CSF (area under curve = 0.88, p < 0.001). When the sVCAM-1 level was higher than 111.57 ng/mL, the sensitivity for predicting CSF was 87% and the specificity was 73%. Conclusions: Plasma sVCAM-1 level can be used to predict CSF and was associated with the clinical symptoms of patients. It may serve as a potential biomarker for CSF in the future.
The Effect of High Molecular Weight Hyaluronic Acid and Latanoprost Eyedrops on Tear Functions and Ocular Surface Status in C57/BL6 Mice
Authors: Dogru Murat , Kojima Takashi , Higa Kazunari , Igarashi Ayako , Kudo Haruka , Müller-Lierheim Wolfgang G. K. , Tsubota Kazuo , Negishi Kazuno
Published: January 2023

Anti-glaucoma eye drop treatment often induces ocular surface problems, including dry eyes, and may be associated with poor medication compliance. This study aimed to investigate the effects of a novel high molecular weight hyaluronic acid and Latanoprost eye drop on intraocular pressure, as well as the tear function and ocular surface alterations in wild type mice, comparing the results with the mice receiving commercially available Latanoprost eye drops and mice receiving no treatment. The mice were divided into three groups: Group I, control group (no treatment group); Group II, commercial Latanoprost eye drop (LP); and Group III, Comfort Shield (CS) + Latanoprost (LP) eye drop (CS + LP). The CS + LP eye drop group had an IOP lowering effect comparable to the commercial LP eye drop group. The mice receiving LP eye drops had significantly worse corneal staining scores, lesser goblet cell density(GCD), higher numbers of CD45+ staining cells, significantly higher tear film concentrations of IL-6 and IL1-b, and a significantly lower expression of corneal ZO-1 mRNA compared with the mice receiving CS + LP 7 days after eye drop instillations (p < 0.05). In conclusion, the new CS + LP formulation appeared to induce less inflammation, less corneal vital staining, and a better barrier status with an IOP lowering effect comparable to the commercial LP eye drops.
Investigating Factors Associated with Fear of Falling in Community-Dwelling Older Adults through Structural Equation Modeling Analysis: A Cross-Sectional Study
Authors: dos Santos Elane Priscila Rosa , Ohara Daniela Gonçalves , Patrizzi Lislei Jorge , de Walsh Isabel Aparecida Porcatti , Silva Caroline de Fátima Ribeiro , da Silva Neto José Ribeiro , Oliveira Nayara Gomes Nunes , Matos Areolino Pena , Iosimuta Natalia Camargo Rodrigues , Pinto Ana Carolina Pereira Nunes , Pegorari Maycon Sousa
Published: January 2023

The scientific literature mentions the existence of factors associated with fear of falling in older adults. However, the direct and indirect paths of its predictors have not yet been fully explored. This study aimed to analyze the socioeconomic, clinical, and health factors directly and indirectly associated with fear of falling in community-dwelling older adults. This is a cross-sectional study conducted in older adults (n = 410 – 70.11 ± 7.22 years). Clinical and health-condition data were collected, as were data on fear of falling using the Falls Efficacy Scale International—Brazil (FES-I Brazil). It was found that being female and having a higher number of self-reported morbidities, worse physical performance, and a higher number of depressive symptoms were directly associated with greater fear of falling. Regarding indirect associations, physical inactivity, mediated by a greater number of morbidities, worse physical performance, and a greater number of depressive symptoms, was associated with greater fear of falling. In addition, worse self-rated health, mediated by a greater number of depressive symptoms, as well as older age, mediated by worse physical performance, were associated with the outcome. This study provides information on the predictors directly and indirectly associated with fear of falling, expanding current understanding of this relationship.
Intraoperative Hemoadsorption (Cytosorb™) during Open Thoracoabdominal Aortic Repair: A Pilot Randomized Controlled Trial
Authors: Doukas Panagiotis , Hellfritsch Gabriel , Wendt Daniel , Magliani Mirko , Barbati Mohammad E. , Jalaie Houman , Jacobs Michael J. , Gombert Alexander
Published: January 2023

Background: The efficacy of cytokine adsorption in controlling the early inflammation cascade after open thoracoabdominal aortic (TAAA) repair has not been investigated. The aim of this pilot randomized controlled trial was to assess the feasibility and effect of perioperative hemoadsorption during open TAAA repair. Methods: Patients scheduled for open TAAA repair with the use of cardiopulmonary bypass (CPB) were included. The patients were randomized the day before surgery to either intraoperative hemoadsorption during CPB or standard of care. Results: A total of 10 patients were randomly assigned to the intervention group, whereas the control group consisted of 17 patients (mean age of the total cohort, 51.1 ± 11.2 years, 67% male, 3 patients not randomized). The majority of baseline and perioperative characteristics were similar, and no device-related adverse events were reported. A trend to shorter ventilation times in the intervention group was observed (median 88 h vs. 510 h, p = 0.08, Δ422). Severe acute respiratory distress syndrome was significantly less in the intervention patients (p = 0.02). Conclusions: This is the first pilot study showing that the intraoperative use of hemoadsorption in open TAAA repair patients may be feasible and safe, yet larger trials are needed to evaluate whether intraoperative hemoadsorption is associated with improved clinical outcomes.
Differentiated Effect of Smoking on Disease Activity and Quality of Life among Different Spondyloarthritis Phenotypes
Authors: Alonso-Castro Sara , García-Valle Andrea , Morante-Bolado Isla , Braña Ignacio , Pardo Estefanía , Queiro Rubén
Published: January 2023

Background and aims: The effect of smoking on disease activity and quality of life (QoL) in spondyloarthritis (SpA) is far from clear. We aimed to evaluate the relationship between smoking and these outcomes in patients with axial SpA (axSpA) and psoriatic arthritis (PsA). Patients and methods: This cross-sectional observational multicenter study included 242 patients with axSpA and 90 with PsA. The association between conventional cardiovascular risk factors and disease activity as well as QoL, in both SpA phenotypes was evaluated. For this, univariate and multivariate regression analyses were performed, as well as confirmatory meta-analyses. Results: Regardless of age, sex, or disease duration, patients with axSpA showed significantly less association with obesity (OR 0.50 (0.26–0.96), p = 0.03) and hypertension (OR 0.33 (0.18–0.62), p = 0.0005). However, axSpA was significantly associated with smoking (OR 2.62 (1.36–5.04), p = 0.004). Patients with axSpA were more likely to be in a category of high disease activity compared with PsA (OR 2.86, p = 0.0006). Regardless of sex, age, disease duration, and education level, smoking was significantly associated with higher disease activity in axSpA (OR 1.88, p = 0.027). A fixed-effects model meta-analysis (OR 1.70, p = 0.038) confirmed the association between tobacco and disease activity. No relationship was found between smoking (or other cardiometabolic risk factors) and structural damage or worse QoL in either disease. Conclusions: Although the cardiometabolic risk profile is clearly different between both SpA phenotypes, the only clear link between these factors and increased disease activity was observed between smoking and axSpA. Our findings need further confirmation.
Analysis of Stress Intensity Factor of a Fibre Embedded in a Matrix
Authors: Barzegar Mostafa , Costa Josep , Trias Daniel , Guerrero Jose M. , Lopes Claudio , Gonzalez Carlos
Published: January 2023

The analytical or numerical determination of the stress intensity factor (SIF) in cracked bodies usually assumes the body to be isolated. However, in fibre-reinforced composites, the fibre, which is the main load-carrying component, is embedded in a matrix. To clarify the effect the embedding matrix has on the SIF of the fibre, we propose a 3D computational model of an orthotropic fibre embedded in an isotropic matrix, and compute the SIF using the J-integral method. A parametric analysis based on dimensionless variables explores the effect of the fibre–matrix stiffness ratio as well as the effect of the degree of elastic orthotropy of the fibre. The results show that the SIF is strongly influenced by both factors, and that the matrix reduces the SIF by limiting the crack opening.
BMSCs-Seeded Interpenetrating Network GelMA/SF Composite Hydrogel for Articular Cartilage Repair
Authors: Zheng Kaiwen , Zheng Xu , Yu Mingzhao , He Yu , Wu Di
Published: January 2023

Because of limited self-healing ability, the treatment of articular cartilage defects is still an important clinical challenge. Hydrogel-based biomaterials have broad application prospects in articular cartilage repair. In this study, gelatin methacrylate (GelMA)and silk fibroin (SF) were combined to form a composite hydrogel with an interpenetrating network (IPN) structure under ultraviolet irradiation and ethanol treatment. Introducing silk fibroin into GelMA hydrogel significantly increased mechanical strength as compressive modulus reached 300 kPa in a GelMA/SF-5 (50 mg/mL silk fibroin) group. Moreover, composite IPN hydrogels demonstrated reduced swelling ratios and favorable biocompatibility and supported chondrogenesis of bone mesenchymal stem cells (BMSCs) at day 7 and day 14. Additionally, significantly higher gene expressions of Col-2, Acan, and Sox-9 (p < 0.01) were found in IPN hydrogel groups when compared with the GelMA group. An in vivo study was performed to confirm that the GelMA-SF IPN hydrogel could promote cartilage regeneration. The results showed partial regeneration of cartilage in groups treated with hydrogels only and satisfactory cartilage repair in groups of cell-seeded hydrogels, indicating the necessity of additional seeding cells in hydro-gel-based cartilage treatment. Therefore, our results suggest that the GelMA/SF IPN hydrogels may be a potential functional material in cartilage repair and regeneration.
Juggling the Various Facets of Modern Anatomic Pathology: A Perspective
Authors: Pisapia Pasquale , Troncone Giancarlo
Published: January 2023

Anatomic pathology, along with the role of anatomic pathologists, has significantly evolved over the past several years [...]
Can Marine Hydrothermal Vents Be Used as Natural Laboratories to Study Global Change Effects on Zooplankton in a Future Ocean?
Authors: Dahms Hans-Uwe , Thirunavukkarasu Subramani , Hwang Jiang-Shiou
Published: January 2023

It is claimed that oceanic hydrothermal vents (HVs), particularly the shallow water ones, offer particular advantages to better understand the effects of future climate and other global change on oceanic biota. Marine hydrothermal vents (HVs) are extreme oceanic environments that are similar to projected climate changes of the earth system ocean (e.g., changes of circulation patterns, elevated temperature, low pH, increased turbidity, increased bioavailability of toxic compounds. Studies on hydrothermal vent organisms may fill knowledge gaps of environmental and evolutionary adaptations to this extreme oceanic environment. In the present contribution we evaluate whether hydrothermal vents can be used as natural laboratories for a better understanding of zooplankton ecology under a global change scenario.
Translocation of Loline Alkaloids in Epichloë-Infected Cereal and Pasture Grasses: What the Insects Tell Us
Authors: Popay Alison J. , Jensen Joanne G. , Simpson Wayne R. , Mace Wade J. , Somchit Chanatda
Published: January 2023

Aphids are major pests of cereal and pasture grasses throughout the world, vectoring disease and reducing plant production. There are few control options other than insecticides. Epichloë endophytes that produce loline alkaloids in their hosts provide a possible mechanism of control, with both meadow fescue and tall fescue naturally infected with loline-producing endophytes showing a resistance to Rhopalosiphum padi. We screened Elymus spp. naturally infected with endophytes that produced loline alkaloids at concentrations known to affect aphids on fescue but found no effect on these insects infesting Elymus. A synthetic loline-producing endophyte association with rye also had no effect on the aphids. After hypothesizing that the lolines were being translocated in the xylem in Elymus and rye rather than the phloem, we tested the rye and meadow fescue infected with loline-producing endophytes against a xylem feeding spittlebug. The endophyte in rye inhibited the feeding of the insect and reduced its survival, whereas the endophyte-infected meadow fescue had no effect on the spittlebug but reduced the number of aphids. Lolines applied to the potting medium of endophyte-free and endophyte-infected rye, ryegrass, and tall fescue resulted in a decrease in the aphid populations on the endophyte-free pasture grasses relative to the untreated controls but had no effect on aphid numbers on the rye. We tentatively conclude that lolines, produced in both natural and synthetic association with Elymus and rye, are partitioned in the xylem rather than the phloem, where they are inaccessible to aphids.
Multi-Criteria Evaluation Method in the Field of University Education: Application to a Course on Energy Markets
Authors: Alcázar-Ortega Manuel , Montuori Lina , Rodríguez-García Javier , Vargas-Salgado Carlos
Published: January 2023

The Bologna Plan adopted by European universities ended the hegemony of an evaluation system exclusively based on the performance of traditional examinations. In this area, with a view to revitalizing grading models in university education, a wide range of evaluation mechanisms has been developed in recent years. Using them, teachers may evaluate the learning levels of their students, including both the specific competences of the taught subject and the transversal competences that help students further develop their professional careers. This article presents a methodology based on a multi-criteria procedure through which students could be evaluated from different points of view, based on different types of evaluation mechanisms that are diversely weighted. Therefore, their levels of learning could be assessed more objectively. This article shows a practical case of applying this methodology, which has been used for the last five years in a course on energy markets taught as part of the Degree in Energy Engineering at the UPV.
Defining and Regulating Peri-Urban Areas through a Landscape Planning Approach: The Case Study of Turin Metropolitan Area (Italy)
Authors: Gottero Enrico , Larcher Federica , Cassatella Claudia
Published: January 2023

Peri-urbanization is a global phenomenon strongly linked to socio-demographic and settlement dynamics. Although peri-urbanization is a topic widely debated in academic literature, especially in the field of urban and regional planning, there is no universal definition, and different types and interpretations of peri-urban areas can be found in the literature. Identifying physical limits and boundaries, as well as defining what is peri-urban and what is not, are important issues for planning these spaces at city and metropolitan levels but are not easy to solve due to their heterogeneity. Establishing land use rules for peri-urban areas is a crucial issue for maintaining and fostering primary and vital ecosystem services, especially in terms of functions provided to urban core areas. Developing a replicable method to identify and regulate peri-urban areas, exportable to other European countries, is the aim of this study. In this paper, the authors propose a method applied to the case study of Turin (Italy), based on a collaborative and place-based approach, the identification of certain peri-urbanization conditions, and the definition of rules and guidelines for peri-urban areas, in order to support decision-makers at different levels. These planning tools were adopted by the recent General Territorial Plan of the Turin Metropolitan Area (TMA). In conclusion, the authors highlighted not only the strengths and possible limitations of this method but also the role of the landscape planning approach in terms of the protection and management of peri-urban areas, considering some of the new challenges that will likely involve future peri-urban research and planning practices.
Intercropping with Pigeonpea (Cajanus cajan L. Millsp.): An Assessment of Its Influence on the Assemblage of Pollinators and Yield of Neighbouring Non-Leguminous Crops
Authors: Layek Ujjwal , Kundu Arijit , Das Nandita , Mondal Rajib , Karmakar Prakash
Published: January 2023

Intercropping is practiced in modern intensive agriculture considering many benefits, including additive crop yield. However, it may have competitive or facilitative interactions between pollinator-dependant crops. Here, we investigated the reproductive aspects of pigeonpea (Cajanus cajan). We assessed the influence of blooming pigeonpea on pollinator’s assemblage and the yield of neighbouring non-leguminous crops (e.g., coriander, mustard). For these, we recorded floral visitors and the yield of the targeted crops from two types of fields―closely situated and distantly situated concerning pigeonpea plantation. Pigeonpea is autogamous, but pollinator’s visits enhance fruit and seed sets. Bright, nectariferous flowers emitted several volatile organic compounds and were visited by numerous insect species. The prime pollinators of pigeonpea are carpenter bees and leafcutter bees. In contrast, halictidae, honeybees and stingless bees mainly pollinate the co-blooming non-leguminous crops (coriander and mustard). The richness and abundance of pollinators on these co-blooming crops remain similar in closely situated and distantly situated fields. As a result, the yield of the neighbouring crops is not significantly influenced by the blooming pigeonpea. Therefore, it can be concluded that planting pigeonpea in ridges of agricultural fields will be an additional agricultural output without affecting the assemblage of pollinators and yields of neighbouring co-blooming crops.