bluuebunny/crossref_metadata_2025 huggingface dataset:
Atypical Teratoid Rhabdoid Tumor of Central Nervous System in an Infant: A Case Report
Authors: Смирнова Анна Юрьевна , Суспицын Евгений Николаевич , Имянитов Евгений Наумович , Белогурова Маргарита Борисовна , Диникина Юлия Валерьевна
Published: March 2024

Введение. Атипичные тератоид-рабдоидные опухоли (АТРО) являются чрезвычайно редкими агрессивными новообразованиями детского возраста с преимущественной встречаемостью у пациентов до 3 лет и доминирующей локализацией в пределах центральной нервной системы (ЦНС). Несмотря на интенсивные комплексные методы терапии, прогноз у данной категории больных остается неудовлетворительным.
Описание случая. Нами представлен случай агрессивного течения первично-метастатической АТРО в сочетании с глиомой низкой степени злокачественности у пациентки первого года жизни с синдромом предрасположенности к рабдоидным опухолям I типа (наследственной мутацией в гене SMARCB1). Применение комплексной интенсивной противоопухолевой терапии, согласно рекомендациям Медицинского университета Вены (MUV ATRT) и метрономной химиотерапии, сопровождалось длительным эффектом. Тем не менее при последующем стремительном прогрессировании заболевания все попытки лечения оказались безрезультатными, и пациентка скончалась спустя 44 месяца после постановки диагноза.
The Significance of Xenogenic Models of Malignant Neoplasms In Vivo for Preclinical Studies in Experimental Oncology
Authors: Хумаири Ахмед Хамид , Рыбалкина Ольга Юрьевна , Чердынцева Надежда Викторовна , Удут Владимир Васильевич
Published: March 2024

Важную роль в экспериментальных исследованиях противоопухолевых соединений играют модели ксеногенных опухолей in vivo. Несмотря на достигнутые в этой области успехи, вероятность того, что новое лекарственное противоопухолевое средство будет одобрено для использования в онкологической клинике, остается невысокой. Такая низкая воспроизводимость экспериментальных результатов в клинике связана с тем, что существующие стандартные модели злокачественных новообразований in vivo, имеют невысокую прогностическую значимость. Тем не менее эксперименты на лабораторных моделях ксеногенных опухолей играли и продолжают играть ключевую роль в апробации и продвижении потенциальных противоопухолевых препаратов в клинику. В данном обзоре представлен анализ отечественной и зарубежной литературы, посвященной созданию и применению ксеногенных моделей in vivo в области экспериментальной онкологии.
Diagnostic Options in Preoperative Assessment of Tumor Spread in Biliary Cancer — a Literature Review
Authors: Поляков Александр Николаевич , Романова Ксения Александровна , Котельников Алексей Геннадьевич , Умирзоков Анваржон Шовкатович , Сагайдак Игорь Всеволодович , Егенов Омар Алиевич , Тулин Павел Евгеньевич
Published: March 2024

Цель обзора — определить роль методов предоперационного обследования у больных билиарным раком. При билиарном раке хирургическое вмешательство является потенциально радикальным методом, кандидаты на операцию — пациенты с локализованными формами опухоли. Стандартные лучевые методы диагностики, в первую очередь КТ и МРТ, позволяют оценить первичную опухоль, сосудистую инвазию, а также выявить регионарные и отдаленные метастазы. МРТ в большей степени подходит для оценки внутрипеченочной распространенности, точность в диагностике истинно-множественного поражения печени при внутрипеченочной холангиокарциноме достигает 100 %. Целесообразно применять МРТ для определения степени вовлечения желчных протоков. КТ более предпочтительна для диагностики внепеченочных метастазов, при сходной с МРТ чувствительностью метод обладает большей специфичностью (80,7 % против 72,9 %, р = 0,01) в определении лимфогенных метастазов. Также КТ позволяет более корректно оценить сосудистую инвазию и степень вовлечения прилежащих к опухоли структур — чувствительность достигает 90 %. Отметим, что даже совместное применение КТ и МРТ у больных билиарным раком не позволяет распознать до лапаротомии признаки нерезектабельности у 25-30 % больных. При подозрении на наличие метастазов целесообразно применять ПЭТ/КТ. Чувствительность метода в определении метастазов колеблется от 30 до 88 %, но стоит указать на высокую, выше 90 %, специфичность метода. Есть сторонники широкого применения диагностической лапароскопии при раке желчного пузыря, а также при раке проксимального отдела внепеченочных желчных протоков, объясняя свою точку зрения высоким, до 27 %, уровнем имплантационных метастазов. Далеко не все разделяют подобное мнение, отмечая невысокую, на уровне нескольких процентов, частоту выявления метастазов по брюшине при билиарном раке и возрастающие возможности лучевых методов диагностики.
Заключение. Планируя хирургическое вмешательство у больных билиарным раком, следует применять МРТ или КТ в качестве основного диагностического метода. Для решения узких диагностических задач перечень методов может быть расширен. ПЭТ/КТ и диагностическую лапароскопию следует использовать, если результаты стандартного обследования неоднозначны.
Late-Line Antitumor Treatment for Metastatic Colorectal Cancer
Authors: Осипов Михаил Анатольевич
Published: March 2024

Введение. Колоректальный рак (КРР) занимает одно из ведущих мест в структуре онкологической заболеваемости. Лечение метастатического колоректального рака (мКРР) в 1-й и 2-й линиях достоверно улучшает общую выживаемость (ОВ). Проблема выбора терапии в поздних линиях заключается прежде всего в том, что предлеченным больным необходимо подобрать терапию, которая при управляемой токсичности сможет быть эффективной и улучшить показатели выживаемости. Цель — анализ данных литературы о современных методах лекарственного лечения мКРР в поздних линиях с учетом персонификации лечения в зависимости от молекулярно-генетических характеристик опухоли и факторов, влияющих на отдаленные результаты лечения.
Результаты. В обзоре систематизированы данные литературы о вариантах терапии мКРР в 3-й и последующих линиях, сделан акцент на персонификацию лечения в зависимости от различных факторов.
Выводы. Большинству больных мКРР в 3-й линии показана терапия трифлуридин/тирирацилом в сочетании с бевацизумабом, вне зависимости от статуса мутации KRAS. Монотерапия регорафенибом или трифлуридином типирацилом обладает меньшей эффективностью, в особенности при наличии неблагоприятных факторов, таких как время от диагноза метастатической болезни менее 18 месяцев, большая опухолевая масса и наличие метастазов в печени. При наличии мутации BRAF или гиперэкспрессии HER2 целесообразен более прецизионный подход с использованием таргетной терапии — анти BRAF и MEK ингибиторов в сочетании с EGFR терапией, а также комбинация трастузумаба с пертузумабом соответсвенно. Иммунотерапия также может быть использована у больных, ранее ее не получавших с опухолями, ассоциированными с микросаттелитной нестабильностью.
La latencia de lo inerte: arquiologías fronterizas
Authors: Garrido López Fermina , Llorens Mara Sánchez , Huarte María Jesús
Published: March 2024

El enfoque interdisciplinario reflexivo de la arquiología busca establecer un cruce temporal entre pequeñas historias de lo humano y relatos de lo inerte para reinterpretar aspectos del pasado y proyectarlos hacia el futuro. El acercamiento teórico y empírico, en el marco de una investigación de tipo prospectivo y metodología activa, permite combinar el rastreo y la reconstrucción de lo latente como haría la arqueología, con conocimientos arquitectónicos y la cronología del paisaje como la estudiaría la geología. Como caso de estudio se atraviesa la isla Martín García, espacio fronterizo seco entre Argentina y Uruguay y se reúnen, en un mapa en proceso, registros de viaje, relatos y mapas abiertos a nuevos aportes e interpretaciones para redefinir la noción de frontera. Este planteamiento polímata-reflexivo revisa y reinterpreta mediante la comparación aspectos del pasado para proyectarlos y poder definir un posible neo-homo contemporáneo, para ir más allá de la noción convencional de fronteras y construir una serie de imaginarios que articulen la aproximación a un paisaje particular, con potencialidad de concierto entre bordes.
Penilaian dan Evaluasi Modul P5 Tema Gaya Hidup Berkelanjutan pada Materi Keseimbangan Ekosistem
Authors: Putri Andini Nasution  , Rian Vebrianto  , Yovita Yovita
Published: March 2024

Kurikulum Merdeka menghendaki pengembangan profil pelajar Pancasila, salah satunya melalui kegiatan P5. Modul P5 dikembangkan sebagai panduan untuk memudahkan proses pembelajaran guna penguatan profil Pancasila. Berdasarkan wawancara peneliti terhadap Guru kelas V SD Muhammadiyah 6 Pekanbaru, diketahui bahwa ketersediaan modul P5 disekolah masih sangat minim, diasamping itu tidak semua guru mampu mengembangkan modul secara mandiri. Sebagai alternatif solusi penelitian ini kemudian bertujuan untuk mengembangkan Modul P5 tema gaya hidup berkelanjutan dan melakukan penilaian dan evaluasi Modul Projek P5 tema gaya hidup berkelanjutan pada materi keseimbangan ekosistem. Penelitian ini menggunakan metodologi Research and Development (RnD) dengan model instruksional pengembangan ADDIE. Dalam proses evaluasi, penelitian ini melibatkan 6 pakar untuk memvalidasi Modul tersebut menggunakan instrumen validasi Modul. Sedangkan untuk penilaian praktikalitas, penelitian ini melibatkan 30 orang siswa dan 10 guru kelas menggunakan instrumen praktikalitas Modul. Proses analisis data menggunakan SPSS secara deskriptif untuk menggambarkan hasil dari penilaian Modul tersebut. Hasil penelitian menunjukkan bahwa Modul memiliki kategori sangat baik berdasarkan validasi pakar (3,5), praktikalitas guru (4,23), dan praktikalitas siswa (4,03). Dengan demikian, disimpulkan bahwa Modul layak untuk digunakan dan diharapkan dapat menjadi alternatif perangkat ajar dalam implementasi P5 di Sekolah Dasar.
Innovación Educativa: Integrando las TIC en la Educación Superior
Authors: Lozano Camacho Franklin Eduardo , González Carrión Erika Lucía
Published: March 2024

Las tecnologías de la información y comunicación (TIC) representan uno de los cambios e implementaciones más significativas de los últimos tiempos, asociadas a la Cuarta Revolución Industrial y que posibilitan el aceleramiento y productividad en diferentes actividades del día a día, a más de la aplicación transversal en diferentes campos de desarrollo. El objetivo del presente estudio atiende a realizar una revisión bibliográfica de documentos académicos y científicos de los últimos 5 años en atención a las TIC como innovación educativa, puntualmente en su aplicación en la educación superior. Como resultados precisamente se reconoce la importancia e incidencia de las TIC en el contexto educativo desde la innovación, posibilitando la generación de espacios de formación colaborativos, motivadores y que impulsen la interacción entre docentes y estudiantes y estudiantes y sus pares, tanto dentro como fuera del aula. Con la información recopilada se concluye que las TIC tienen un papel cada vez más visible en la educación, y en el caso de la educación superior como respuesta a los cambios generacionales y a una sociedad más tecnológica y digital.
Efecto del Parque Automotor en el Nivel de Contaminación por Dióxido de Carbono en la Ciudad de Puno
Authors: Flores Yucra Ruben , Ginez Choque Percy Arturo , Alfaro Alejo Roberto , Flores Quispe Eduardo Luis , Flores Condori Eduardo
Published: March 2024

La emisión de gases vehiculares en la ciudad de Puno se caracteriza por una gran cantidad de unidades que circulan, cantidad que ha venido aumentando de manera gradual en los últimos años, estas unidades utilizan principalmente una variedad de combustibles como gasolina y el diesel de procedencia extranjera. Existe un alto nivel de contaminación a través de las emisiones. Esta investigación tiene como objetivo determinar el nivel (% en volumen) de contaminación de emisión de gases (CO2, CO), las emisiones de combustión de vehículos se han cuantificado a través de un dispositivo analizador de gases E-5500. Se estimó que el nivel de dióxido de carbono (CO2) fueron de 1.10 a 18.70% en 16 puntos de monitoreo con un promedio del 11.99%, el rango de monóxido de carbono (CO) es de 100 ppm (0.01%) a 1088 ppm (0.1088%) con un promedio 470.05 ppm (0.047%) y el promedio del dióxido de carbono con el monóxido de carbono (CO2 + CO) es 12.03%. La variación espacial a nivel de la ciudad de Puno mostró un comportamiento por debajo del límite máximo permisible (LMP) en Perú y en comparación con otros países como Colombia y México. Las emisiones de CO2 son estadísticamente diferentes a las concentraciones de O2, siendo mayores las concentraciones de O2 (p<0.05), por lo cual el nivel de contaminación es aun tolerable para la salud humana. La utilidad de esta información radica en la elaboración de un mapa de monitoreo de emisión de gases definidos, lo que puede ayudar a determinar que esta variable de emisión de automóviles contamina, así como a promover las regulaciones de la industria y así como el uso de fuentes de energía menos contaminantes y la implementación de nuevas tecnologías para garantizar un apoyo de combustión más eficiente para reducir el impacto ambiental de las emisiones de gases de flota vehicular, contribuyendo a la descarbonización.
Flow Simulation Study on Bed Bath for Bedridden Patient
Authors: nur hazwani mokhtar  , N. F Azmi  , B. R Mizah  , Abdul Rafeq Saleman  , M H Ismail
Published: March 2024

Easy tasks such as showering or bathing independently are impossible for a bedridden individual. This paper presents a comprehensive study on designing an easy shower specifically tailored for bedridden patients. The challenges bedridden individuals face in maintaining personal hygiene are highlighted, emphasizing the importance of a suitable bathing system to enhance their quality of life. The proposed design aims to address these challenges and improve caregiving efficiency. The chosen methodology involves a weighted decision matrix to select the optimal design, followed by flow simulation using SolidWorks Flow Simulation software to evaluate its performance. The paper's objectives include designing an efficient easy shower model, assessing its performance via simulation, and analyzing the impact of various velocity settings on its functionality. Three design concepts were proposed, with Design A selected as the optimal choice due to its lightweight, high water capacity, ease of handling, and low production cost. Modifications were made to enhance its water pressure efficiency. The simulation encompassed different velocity settings, with flow trajectories analyzed within the tank and at the water outlet. These boundary conditions included analysis type (internal), fluids (water), default wall thermal condition (adiabatic wall), pressure (101325 Pa), temperature (293.2 K), and velocity in the Y direction (5 m/s for water inlet and 0.5 m/s for water outlet). In the first simulation, all the results obtained were within the specified velocity range of 0.5 m/s, 2 m/s, and 5 m/s. The analysis of flow trajectories revealed distinct flow patterns and velocities for different velocity values, indicating stable and controlled environments within the tank and efficient water discharge through the outlet in Design A. However, errors were observed in the water outlet simulation due to the presence of vortices, which impacted the results. Recommendations were made to address these challenges, such as modifying the design to eliminate or minimize vortex effects. In conclusion, this study contributes to the well-being of bedridden patients by proposing an improved bathing mechanism, enhancing caregiving efficiency, and offering insights into design optimization and simulation challenges. The proposed design could have a significant positive impact on the lives of bedridden patients and caregivers.
The Velocity, Temperature and Concentration Profiles for Triple Diffusive Casson Fluid Flow Subjected to the Soret-Dufour Parameters
Authors: Siti Suzilliana Putri Mohamed Isa  , Nanthini Balakrishnan  , Nurul Syuhada Ismail  , Norihan Md. Arifin  , Fadzilah Md Ali
Published: March 2024

The triple-diffusive convection with the involvement of non-Newtonian fluid has many applications in the science and technology field, industrial processes, and also in research works. Therefore, the mathematical model of the triple-diffusive convection of Casson fluid by the mathematical approach is investigated. In addition, a mathematical model for the triple-diffusive convection of Casson fluid flow beyond a nonlinear compressing sheet has been formulated and solved by numerical approach, where this is the main objective of this study. This model is subjected to mass transfer and heat transfer, known as Soret and Dufour effect (Soret-Dufour). The Soret effect is occurred when the temperature gradient is produced, whereas the differences in mass cause the Dufour effect. The model is formed by the continuity equation, momentum equation, energy equation, and concentration equations of component 1 and 2, together with the boundary conditions. They have been reduced to ordinary differential equations, and subsequently, they have been implemented in bvp4c programme provided by MATLAB software to get the numerical solutions. The solutions obtained were profiles of velocity, temperature and concentration of both components. Next, the effect of Casson parameter, Soret parameter, and Dufour parameter have been investigated by changing their values of inside the coding in MATLAB and observing the behaviour of the related profiles due to these parameters. The main results from this study were: The velocity of the Casson fluid reduced as the Casson parameter enhanced, increment in both Soret and Dufour parameters caused the temperature to decrease, and the fluid concentration was higher for the increasing Soret number.
Salinity-Various Flow Characteristics Investigation in an Identical Meandering Channel
Authors: Siti Nurhayati Mohd Ali  , Nuryazmeen Farhan Haron  , Zulkiflee Ibrahim  , Mazlin Jumain  , Md Ridzuan Makhtar  , Wan Nor Afiqa Wan Mustafah Kamal  , Azanni Nur Izzati Jamaludin
Published: March 2024

Estuaries are one of the most productive ecosystems in the world, providing significant resources for humans and animals. However, the influence of various rainfall patterns due to climate change has affected the estuarine system, leading to changes such as salinity intrusion. This study aims to verify how river discharge changes affect salinity mixing within a meandering channel and the effect of flow patterns due to curvature. An experimental hydraulic investigation was conducted at Universiti Teknologi Malaysia (UTM) Johor Bahru. The cross-sectional profiles along the meandering channel are discussed in this paper. The findings prevailed as a typical characteristic of the salt-wedge estuary and indicated the process of estuarine mixing. As the saltwater flow upstream, the salinity level drops due to the dilution process. Additionally, the greater density of seawater compared to freshwater causes it to remain in the lower layers of the water column. The flow pattern in curvature is influenced by the velocity of the inner and outer banks, where velocity has been seen to be higher at the outer bank, allowing the salinity to flow quickly near the inner bank. The present study will be useful in predicting the estuarine salinity response to river inflow.
Simulation of Heat Transfer during Paraffin And Gallium Melting and Solidification Processes Utilizing Star CCm+
Authors: Rasha Abdulrazzak Jasim  , Wajdi Qasim Hussen  , Mahir Faris Abdulla  , Isam  , Rozli Zulkifli
Published: March 2024

Energy storage systems are essential as the world works to minimize its dependency on fossil fuel energy for environmental and economic reasons. Because of their high capacity for latent heat storage. The numerical study of benchmark cases of solidification and melting was undertaken, and the results of these investigations are presented in this project. Numerical analysis is conducted to examine the brief solidification process of a pure liquid phase-change material within a rectangular enclosure when natural convection is present. The horizontal boundaries are both taken to be adiabatic, with one vertical barrier maintained at a temperature below the material's melting point and the other above. In this work, a numerical investigation of the melting of wax (namely N-octadecane) is presented. The numerical simulations of the experiments were carried out using STAR CCM+, and the results were compared with the results of other numerical simulations (FLOW 3D). The numerical simulations of gallium melting were carried out with a commercial code, STAR CCM+, which captures the solid-liquid interface with a fixed grid. This software captures the solid-liquid interface for phase change simulations in complex geometries with the enthalpy formulation technique. In addition, it demonstrates that computational fluid mechanics has reached a state of development where it permits reliable flow computations with solidification and melting. Casting with metal melts can be studied to provide information to engineers during the design process of new casting tools. The available simulation tools can also be used to predict existing casting processes and determine the origins of defects. The key findings are as follows: The interface shape during the solidification of gallium from above is always determined in large part by anisotropy in heat conductivity and interface growth morphology. Natural convection in the liquid slows down the rate of melting and adds more complexity to the morphology and transport mechanisms at the interface.
Numerical Study of Chemical Reaction and Magnetic Field Effects on MHD Boundary Layer Flow over a Flat Plate
Authors: Funmilayo Helen Oyelami  , Bidemi Olumide Falodun  , Ebenezer Olubunmi Ige  , Olaide Yetunde Saka-Balogun
Published: March 2024

This investigation explores the combined effects of magnetic fields and chemical reactions on the movement of a boundary layer toward a flat plate. The study considers the influence of viscous dissipation on the energy distribution. By utilizing partial differential equations (PDEs), the flow phenomenon is modeled. Through the application of suitable similarity transformations, the system of PDEs is transformed into a system of total differential equations. These modified equations are then solved using the spectral homotopy analysis method (SHAM), which incorporates the combination of the CSCM and HAM procedures. The analysis reveals that magnetohydrodynamic (MHD) fluxes generate a Lorentz force, and a higher magnetic parameter intensifies this effect, resulting in a flattened velocity profile. Furthermore, the velocity profile improves with an increase in the chemical interaction variable. The study also shows that as the Eckert number increases, the ambient temperature of the dense dissipative fluid rises. The findings have potential applications in various engineering fields, such as petroleum pipeline flow improvement. The spectral homotopy method used in this study offers a numerical solution for analyzing the problem. The results contribute to the understanding of heat and mass transfer phenomena and can guide future research in this area.
Investigation of Digestion Processes in the Stomach and Duodenum using Computational Fluid Dynamics Model
Authors: Marat Kamaltdinov  , Peter Valentinovich Trusov  , Nina Vladimirovna Zaitseva
Published: March 2024

The stomach and intestines play an important role in homogenizing the contents of the tract, mixing food with enzymes. The study of digestion processes in a fed state remains difficult by experimental methods. Using computational fluid dynamics models it is possible to obtain flow characteristics at any point in the computational domain. At the previous stages of research, we developed a model to describe the flow of a multiphase multicomponent mixture in the antroduodenum, taking into account the processes of mass transfer between phases, biochemical reactions, mass sources and effluents. In this article, we propose an improvement of the model for describing the multiphase flow in the whole stomach and duodenum, taking into account the gas phase. The mathematical formulation of the problem includes the balance equations of mass and momentum for a multiphase medium with mass sources. Boundary conditions take into account the peristalsis of the tract. In numerical experiments we studied the influence of the density of food particles on the distribution of volume fractions of phases, mass fractions of food components and enzymes, pH level in the digestive tract. In the future, it is necessary to continue working with the rheological properties of the flow.
PERPUSTAKAAN ISLAM CORDOBA: KIBLAT PERADABAN ILMU PENGETAHUAN DI ERA DINASTI BANI UMAYYAH II 961-976 M
Authors: Iqbal Rahmat , Agus Mahfudin Setiawan
Published: March 2024

The Islamic Library in Cordoba was one of the leading libraries of its time, offering various fields of knowledge, including collections of Islamic and European history. This research aims to understand the development of scientific civilization which became a mecca of progress in Europe during the Second Umayyad Dynasty. This research methodology uses a library research approach with data collection through literature, documentation (both printed and electronic), as well as data and information sources relevant to the study. The findings in this study show that the development of science in Cordoba during the Second Umayyad Dynasty was driven by the construction of academies and libraries. The palace library in Cordoba, built by Caliph Abdurrahman, was one of the best libraries in the Islamic world at the time. It was staffed by a librarian called a "bakiya," and involved copyists and bookbinders. The glittering development of Islamic libraries during the Umayyad period had a great influence on the civilization of Arab society, making the Cordoba Library a center of advanced civilization in Europe. The existence of this library became the foundation for increasing knowledge and learning throughout the region, having a positive impact on civilization and culture at that time.
Ứng dụng bảng kiểm M-CHAT trong đánh giá trẻ rối loạn phổ tự kỷ
Authors: Nguyen Thi Diem Chi
Published: March 2024

TÓM TẮT

Mục tiêu: Xác định liên quan giữa mức độ nguy cơ theo M-CHAT với mức độ rối loạn phổ tự kỷ theo Sổ tay Chẩn đoán và Thống kê các Rối loạn Tâm thần, lần thứ 5 (DSM-5) ở trẻ 18 - 36 tháng tuổi bị rối loạn phổ tự kỷ.

Đối tượng, phương pháp: Thực hiện nghiên cứu mô tả, cắt ngang 59 trẻ từ 18 - 36 tháng tuổi được chẩn đoán rối loạn phổ tự kỷ theo DSM-5. Tiến hành phỏng vấn ba mẹ của trẻ và thăm khám đánh giá trẻ theo bảng kiểm M-CHAT; đối chiếu với các tiêu chí chẩn đoán xác định RLPTK theo DSM-5.

Kết quả: Có mối liên quan giữa mức độ nguy cơ RLPTK theo M-CHAT và mức độ RLPTK theo DSM-5 ở nhóm triệu chứng về bất thường về giao tiếp và tương tác xã hội của trẻ. Có mối liên quan giữa mức độ nguy cơ RLTPK theo M-CHAT và mức độ RLPTK theo DSM-5 ở nhóm triệu chứng về bất thường về hành vi, ham thích và hoạt động của trẻ.

Kết luận: Bảng kiểm M-CHAT đơn giản, dễ sử dụng; có thể ứng dụng trong sàng lọc, phát hiện sớm rối loạn phổ tự kỷ ở trẻ em.

ABSTRACT

THE USE OF MODIFIED CHECK - LIST AUTISM IN TODDLERS IN EVALUATING CHILDREN WITH AUTISM SPECTRUM DISORDER

Objective: To determine the relationship between the risk of autism spectrum disorder (ASD) according to modified check - list autism in toddlers (M-CHAT) and the level of ASD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) in children aged 18 - 36 months with ASD.

Methods: A cross - sectional study was conducted on 59 children aged 18 - 36 months who diagnosed with autism spectrum disorder according to DSM-5. All children were evaluated using M-CHAT and compared to the diagnostic criteria for autism according to DSM-5.

Results: The study found a relationship between the risk of autism according to M-CHAT and these components according to DSM-5: children demonstrating abnormalities in communication and social interaction (p < 0.05); children with abnormal symptoms of behavior, interests, and activities (p < 0,05).

Conclusions: M-CHAT is simple and easy to use; can be applied in early screening and diagnosing of autism spectrum disorder in children

Keywords: Autism spectrum disorder, M-CHAT, DSM-5, early diagnosis.
Short Introduction to Anger Management
Authors: Chakraborty Nandini
Published: March 2024

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Forensic Psychiatry in the Quisling, Hamsun and Breivik Trials
Authors: Kaplan Robert M
Published: March 2024

The 2011 trial of Andreas Breivik for the mass murder of 69 Norwegian adolescents (plus eight people in an earlier bombing) was dominated by intense debate about his sanity, both in the court and public arenas. Similar controversies arose in two previous high-profile cases: the 1945 trial of the Norwegian collaborator Vidkun Quisling and the 1946 trial of the Nobel Prize winner Kurt Hamsun. Quisling, Hamsun and Breivik were all required to have psychiatric assessment. The findings were intensely disputed. The first assessments produced results the public found unacceptable. After a lengthy and controversial examination, Hamsun was exempted from a criminal trial but had to face a civil procedure in which he lost most of his savings. The public reaction in Breivik’s case went the other way: that he could be exempt from punishment by psychiatric illness caused such fury that legal protocol was overturned, and he was assessed again, this time producing a finding that all found satisfactory. Psychiatric issues in the three trials reviewed show remarkable symmetry, although also with some differences. Issues raised at these trials are the role of public pressure, the conflict between the belief that the perpetrators had to be mad to do what they did and the desire that they not escape due to punishment by psychiatric confinement and the recurrent problem in forensic assessment of assessing extreme overvalue beliefs. The forensic aspects at the trial of Peter Sutcliffe show that these issues were not unique to the Norwegian legal system.
The First Photometric Analysis of Two Low-mass-ratio Contact Binary Systems in TESS Survey
Authors: Cheng Qiyuan , Xiong Jianping , Ding Xu , Ji Kaifan , Li Jiao , Liu Chao , Li Jiangdan , Luo Jingxiao , Lyu Xin , Han Zhanwen , Chen Xuefei
Published: March 2024

Low-mass-ratio (q) contact binary systems are progenitors of stellar mergers such as blue stragglers or fast-rotating FK Com stars. In this study, we present the first light curve analysis of two newly identified low mass-ratio contact binary systems, TIC 55007847 and TIC 63597006, that are identified from TESS. Both stars are classified as A-subtype contact binaries. We obtained the precise orbit periods for the two objects by using the O − C method, i.e., P = 0.6117108 day for TIC 55007847 and P = 0.7008995 day for TIC 63597006, and found an obvious periodic signal in the O − C curve of TIC 63597006. We suggest that the periodic signal comes from a third body. We further use the Markov chain Monte Carlo method with PHOEBE to derive the photometric solutions for the two binaries. The photometric solution for this object shows that the contribution of the third body is about 6%. Our analysis revealed that TIC 55007847 has an extremely low mass ratio of q = 0.08. By calculating the ratio of spin angular momentum to the orbital angular momentum J
s/J
o, we found that TIC 55007847 is very close to the instability threshold with J
s/J
o = 0.31, indicating that it may merge into a single, fast-rotating star in the future. For TIC 63597006, q = 0.14 and J
s/J
o = 0.15. This object is in a relatively stable evolutionary status at present.
The impact of long-distance travel to work on the health of commuting labour migrants: a literature review
Authors: Shitova Yuliya Y.
Published: March 2024

This literature review analyzes the impact of commuting labour migration (CLM) on human health. Travel time is one of the major CLM factors affecting migrant health in both active and passive way. Fatigue and stress associated with commuting result in the increased blood pressure and risk of obesity.

The paper also dwells upon the impact of CLM on worker stress by gender. The article also explores the relationship between CLM and mortality. Work-life balance plays a crucial role in migrant health, while satisfaction with life can be compromised due to insecure life style associated with CLM. There is an effect of adaptation that can influence migrant health in a positive way.

In addition to negative aspects the article reviews benefits of CLM, including improved professional skills and higher income, and effective use of travel time. A special attention is payed to health of the Russian commuting migrants and their specific challenges and problems.

The article is a comprehensive review of scientific literature on CLM impact of human health. the results obtained can be used to develop programs and policies aimed at improving health of labour migrants and mitigating negative effects of commuting labour migration.
The true twin classes-based investigation for connected local dimensions of connected graphs
Authors: Isariyapalakul Supachoke , Pho-on Witsarut , Khemmani Varanoot
Published: March 2024

Let $ G $ be a connected graph of order $ n $. The representation of a vertex $ v $ of $ G $ with respect to an ordered set $ W = \{w_1, w_2, ..., w_k\} $ is the $ k $-vector $ r(v|W) = (d(v, w_1), d(v, w_2), ..., d(v, w_k)) $, where $ d(v, w_i) $ represents the distance between vertices $ v $ and $ w_i $ for $ 1\leq i\leq k $. An ordered set $ W $ is called a connected local resolving set of $ G $ if distinct adjacent vertices have distinct representations with respect to $ W $, and the subgraph $ \langle W\rangle $ induced by $ W $ is connected. A connected local resolving set of $ G $ of minimum cardinality is a connected local basis of $ G $, and this cardinality is the connected local dimension $ \mathop{\text{cld}}(G) $ of $ G $. Two vertices $ u $ and $ v $ of $ G $ are true twins if $ N[u] = N[v] $. In this paper, we establish a fundamental property of a connected local basis of a connected graph $ G $. We analyze the connected local dimension of a connected graph without a singleton true twin class and explore cases involving singleton true twin classes. Our investigation reveals that a graph of order $ n $ contains at most two non-singleton true twin classes when $ \mathop{\text{cld}}(G) = n-2 $. Essentially, our work contributes to the characterization of graphs with a connected local dimension of $ n-2 $.
Mise en perspective de la politique du logement de la Région de Bruxelles-Capitale
Authors: Zimmer Pol
Published: March 2024

Depuis sa naissance en 1989, la Région de Bruxelles-Capitale poursuit en matière de politique du logement deux objectifs essentiels et récurrents : garantir pour l’ensemble des ménages bruxellois l’exercice du droit à un logement adapté et accessible financièrement et, par ailleurs, maintenir sur le territoire régional une population permettant d’alimenter les ressources budgétaires de la Région eu égard au système de financement des Régions en Belgique.Après plus de trente d’existence, caractérisés notamment par une forte croissance démographique et par un appauvrissement de sa population, force est de constater que, à ce stade, la Région de Bruxelles-Capitale est en déficit de concrétisation de ses deux objectifs malgré un volontarisme proclamé et une activité législative importante et inventive.Cet article entend synthétiser les grandes évolutions de la politique du Logement portée par une Ville-Région dont certaines caractéristiques et leurs évolutions sont rappelées.Certaines raisons de la difficulté de concrétiser ces 2 objectifs sont abordées.Par ailleurs, une mise en perspective de cette politique est proposée à travers trois prismes différents qui plaident, de manière solidaire, pour accorder une importance accrue à cette politique pour laquelle d’autres chemins devraient être tentés en même temps qu’une meilleure utilisation des ressources budgétaires qui lui sont consacrées.La question peut être posée sur la manière d’accentuer l’opérationnalité des réponses publiques en revoyant le cadre général de cette politique héritière d’une histoire dont certains termes aujourd’hui ne correspondent pas à l’importance accrue qu’a pris l’accès au logement comme condition nécessaire d’une vie digne et satisfaisante et d’une citoyenneté libre et assumée.
Le travail de parti de Marx
Authors: Quétier Jean
Published: March 2024

Entre la philosophie et l’histoire, cet ouvrage étudie l’activité déployée par Marx au sein des structures militantes dans lesquelles il est successivement intervenu. Il interprète les différentes traces de cette activité, en particulier les procès-verbaux des réunions auxquelles Marx a participé et la correspondance qu’il a entretenue avec de nombreux dirigeants ouvriers. L’analyse de ces documents montre qu’à ses yeux les partis ne constituaient pas de simples caisses de résonance, dont la vocation première aurait été d’accroître la diffusion d’idées élaborées en amont, de façon solitaire, mais qu’ils faisaient au contraire figure de véritables laboratoires théoriques. Ainsi apparaît la distinction entre parti et secte, le premier étant compris comme une forme saine, la seconde comme une modalité pathologique de l’organisation de classe. Marx pense en effet le parti comme une structure démocratique dont le discours s’élabore de façon collective et en lien étroit avec la pratique réelle du mouvement ouvrier.De ce point de vue, la logique partisane s’oppose nécessairement à la pratique sectaire, vestige anachronique du temps des sociétés secrètes, qui se caractérise par sa croyance aux recettes miracles et sa tendance au culte du chef charismatique.
En libération conditionnelle …
Authors: Lambelet Daniel , Franz Lucile , Emprechtinger Julia , Richter Marina
Published: March 2024

Cet article s’intéresse aux expériences temporelles vécues par des personnes astreintes à un suivi probatoire en Suisse. Il permet de comprendre la manière dont cette période transitoire est vécue par les personnes concernées, tout en amenant un regard critique sur le cadrage institutionnel qui régit les suivis dans deux cantons suisses. Il montre que si les personnes en libération conditionnelle sont assujetties à un ordre temporel exogène, elles développent également des stratégies pour l’investir.
La photographie d'Alan Kurdi en 2015. Une crise de conscience éditoriale en contexte migratoire
Authors: Blanc Anthony
Published: March 2024

Le « choc » éprouvé en 2015 par les journalistes devant la photographie d'Alan Kurdi, un enfant syrien d'origine kurde retrouvé mort sur une plage turque, leur a inspiré la plus grande vigilance avant même sa publication. De manière à neutraliser les polémiques, les rédactions ont justifié leurs choix éditoriaux, anticipant ainsi la réaction de leurs lecteurs. Néanmoins, une controverse portant sur la publicisation de cette photographie a traversé les différentes instances médiatiques jusqu'aux publics. Cet article propose de revenir sur la couverture médiatique française de l'événement par les chaînes de télévision et les rédactions. Une étude de réception nous permet d'appréhender la réaction des internautes en réponse aux hésitations des médias. Si les journaux semblent avoir traversé une crise de conscience éditoriale face à cette photographie, nous nous interrogerons aussi sur ce qui a rendu cette image intolérable.
« Manipuler » et co-interpréter les images choc : vers une sémio-poïétique sociale ?
Authors: Appiotti Sébastien , Müller Susanne
Published: March 2024

Dans cet article, nous cherchons à comprendre en quoi la manipulation plastique d'une image choc modifie le regard, et donc l'interprétation, tant du chercheur que de ses enquêtés. Dans un contexte de profond renouvellement de l'éducation critique à l'image, nous mobilisons une approche à la croisée des arts visuels et de la sémiotique sociale. Nous avons expérimenté cette dernière auprès d'étudiants de l'Institut régional du travail social de Lorraine sous la forme d'une co-analyse et d'une manipulation plastique d'une image d'un TGV médicalisé transportant des patients en soins intensifs atteints du Covid-19. Cette démarche s'inscrit dans Je cadre du projet de recherche collectif « Interpréter les images choc en temps de crise sanitaire ». Cet article sera l'occasion de rendre compte des principales hypothèses interprétatives ayant émergé de cette enquête ainsi que d'esquisser notre approche hybride, que nous proposons de dénommer « sémio-poïétique sociale ».
Impact of Climate Change and Occupational Hazards on QoL of Fisherfolk/Fish Processing Communities With Probable Mitigation Strategies
Authors: Naha Nibedita , Rathore Deepsi , Sharma Somi N. , Choudhari Ranjana Hanumant
Published: March 2024

Fishery includes farmed fisheries and wild fisheries; of which, wild fisheries are comprised of marine and freshwater fisheries that provide an important source of food, nutrition, employment and income, mostly in the developing countries including India. However, now-a-days, environmental factors, such as climate change, global warming, heat stress, unpredictable weather patterns, ecological imbalance, etc., causes either direct, or indirect effects on the fishery and fish processing industry; thus, encompass numerous challenges to the quality of life (QoL) of the target communities. Also, the release of greenhouse gases into the atmosphere through man-made activities worsen the situation. Besides, occupational exposure is another major factor due to physical, chemical, biological and psychological stressors that affect the overall productivity of this informal sector. Globally, millions of people are employed in the fishery and fish processing industry though women are the majority in the fish processing work in the developing countries; thereby it demands need-based support programs, national policies and action plans for the benefit of the stakeholders. Further, industry's resilience is dependent on the effective governance, sustainable practices and strong mitigation strategies, where fishing industry is not an exception. Hence, the present book chapter scrutinizes a wide range of environmental and occupational issues confronting the QoL of the communities, as well as explores the potential strategies to mitigate the negative impacts of climate change and occupational hazards in the fisherfolk and fish processing communities.
Marine Mucilage as an Outcome of Climate Change and Pollution
Authors: Yilmaz Adem
Published: March 2024

The seas are home to many living things and an excellent resource for the ecosystem. In addition, the seas are a perfect ecosystem component for both the supply of quality food for humans and the continuation of their lives. Due to the ecological and economic importance of the seas, they should be catered to consciously and in a sustainable fashion. Howbeit, the boost in human-induced problems and nature-induced problems may cause some negativities. This causes an increase in nutrients in the seas, sudden changes in water temperature, a decrease in water currents and consequently, an increase in algae and other phytoplankton. Over time, these organisms cause a substance entitled marine saliva or mucilage to cover the seas and damage the marine ecosystem. In this study, a comparative analysis of the mucilage problem, which has become a significant problem in Türkiye in recent years, is carried out. In this context, the prominent reports, the measures taken and the action plans in Türkiye are examined in detail.
Climate Litigation for Quality of Life
Authors: Karthiayani A. , Gurpur Shashikala , Rautdesai Rupal
Published: March 2024

This proposed book chapter explores novel legal strategies for holding polluters accountable for climate change contributions and protecting affected communities' quality of life. It highlights the limitations of traditional litigation and advocates for innovative approaches. The first section focuses on technological solutions like satellite imagery, remote sensing, and blockchain to gather evidence and enhance supply chain transparency. The second section examines successful collaborative legal initiatives addressing transboundary pollution and global climate injustices. The third section explores integrating climate science, economics, and law in litigation efforts, quantifying damages, and linking pollution to health impacts. The fourth section discusses future directions and challenges, including accountability for future generations. The chapter concludes by emphasizing interdisciplinary collaboration and legal reforms for climate justice and a better future.
Blockchain Technology in Disaster Rescue Wings
Authors: Mukesh Kumar D. , Kumar A. V. Senthil , Irawati Indrarini Dyah , Latip Rohaya , El Emary Ibrahiem M. M. , Musirin Ismail Bin , Abdullah Hesham Mohammed Ali , L. Manjunatha Rao , Chaya S. , Arya Nitin
Published: March 2024

Blockchain, the base of Bitcoin, has recently received broad attention. Blockchain acts as an immutable ledger that allows transactions to take place in a decentralized manner. Blockchain-based applications are growing, covering many sectors, including financial services. The reputation of Blockchain, the base of Bitcoin, has recently received broad attention. Blockchain acts as management, and the internet of things (IoT). During disaster events, timely and targeted information provision and exchange could provide great help to the stricken population in difficult and complicated environments. This chapter reports a service-oriented system, called BlockchainDisaster Rescue Wings, for providing emergency support to sufferers and rescuers in disasters. The authors identify the most frequent request sequence patterns (FRSP) of Rescue Wings, and develop a new application for efficiently scheduling the requests to minimize the response delay. The system has been tested in several disaster rescue drills, and has been successfully applied.
Home Gardening
Authors: Manogaran Pavitira , Mansor Nur Aliah
Published: March 2024

The COVID-19 pandemic brought about social distancing, self-isolation, and movement control orders, leading to an increased demand for food and disruptions in the supply chain. Consequently, home gardening gained popularity as a productive and environmentally friendly activity, inspiring Penang residents to grow their greens. The state government and organisations like Think City and the Consumers' Association of Penang recognised the importance of urban gardening initiatives. This research investigates the impact of home gardening on society, highlighting its potential as an approach to a socialist society and its alignment with sustainable development goals, including zero hunger and climate action. Home gardening promotes self-sufficiency, food security, and sustainable practices, especially in urban areas, contributing to food system resilience. It fosters community involvement, and cohesiveness, enhancing well-being and happiness among gardeners. The study underscores the importance of promoting home gardening to achieve a more resilient and sustainable future for Penang.
Understanding the Unpredictable
Authors: Garg Ankit , Sharma Himanshu , Singh Anubhav Kumar , Sharma Nikhil , Aneja Sakhi
Published: March 2024

The Metaverse is a ground-breaking technology development that has the potential to fundamentally alter how tourism is managed and promoted. Its capacity to provide immersive encounters across both the virtual and physical domains, successfully bridging the gap between the digital and material worlds, is what is driving this transition. Users now have a wide range of options thanks to this ground-breaking idea, which makes it simple for them to move between the physical and digital worlds. People can travel through time in this fully immersive digital environment, where they can virtually experience historical events, go on space expeditions, or even come across dangerous natural phenomena. Users can explore virtual settings for work, education, commerce, following their interests, and engaging with people in this world in addition to sating their wanderlust. Players interact naturally inside this virtual world, demonstrating the Metaverse's influence on the gaming industry and laying the groundwork for its greater potential.