bluuebunny/crossref_metadata_2025 huggingface dataset:
Combining Correlated Outcomes and Surrogate Endpoints in a Network Meta-Analysis of Colorectal Cancer Treatments
Authors: Hoang Tung , Kim Jeongseon
Published: September 2020

This study aimed to investigate the efficacy and safety of systemic therapies in the treatment of unresectable advanced or metastatic colorectal cancer. Predicted hazard ratios (HRs) and their 95% credible intervals (CrIs) for overall survival (OS) were calculated from the odds ratio (OR) for the overall response rate and/or HR for progression-free survival using multivariate random effects (MVRE) models. We performed a network meta-analysis (NMA) of 49 articles to compare the efficacy and safety of FOLFOX/FOLFIRI±bevacizumab (Bmab)/cetuximab (Cmab)/panitumumab (Pmab), and FOLFOXIRI/CAPEOX±Bmab. The NMA showed significant OS improvement with FOLFOX, FOLFOX+Cmab, and FOLFIRI+Cmab compared with that of FOLFIRI (HR = 0.84, 95% CrI = 0.73–0.98; HR = 0.76, 95% CrI = 0.62–0.94; HR = 0.80, 95% CrI = 0.66–0.96, respectively), as well as with FOLFOX+Cmab and FOLFIRI+Cmab compared with that of FOLFOXIRI (HR = 0.69, 95% CrI = 0.51–0.94 and HR = 0.73, 95% CrI = 0.54–0.97, respectively). The odds of adverse events grade ≥3 were significantly higher for FOLFOX+Cmab vs. FOLFIRI+Bmab (OR = 2.34, 95% CrI = 1.01–4.66). Higher odds of events were observed for FOLFIRI+Pmab in comparison with FOLFIRI (OR = 2.16, 95% CrI = 1.09–3.84) and FOLFIRI+Bmab (OR = 3.14, 95% CrI = 1.51–5.89). FOLFOX+Cmab and FOLFIRI+Bmab showed high probabilities of being first- and second-line treatments in terms of the efficacy and safety, respectively. The findings of the efficacy and safety comparisons may support the selection of appropriate treatments in clinical practice. PROSPERO registration: CRD42020153640.
Anti-Retroviral Protease Inhibitors Regulate Human Papillomavirus 16 Infection of Primary Oral and Cervical Epithelium
Authors: Alam Samina , Chatterjee Sreejata , Kang Sa Do , Milici Janice , Biryukov Jennifer , Chen Han , Meyers Craig
Published: September 2020

Epidemiology studies suggest that Human Immunodeficiency Virus (HIV)-infected patients on highly active anti-retroviral therapy (HAART) may be at increased risk of acquiring opportunistic Human Papillomavirus (HPV) infections and developing oral and cervical cancers. Effective HAART usage has improved survival but increased the risk for HPV-associated cancers. In this manuscript, we report that Protease Inhibitors (PI) treatment of three-dimensional tissues derived from primary human gingiva and cervical epithelial cells compromised cell-cell junctions within stratified epithelium and enhanced paracellular permeability of HPV16 to the basal layer for infection, culminating in de novo biosynthesis of progeny HPV16 as determined using 5-Bromo-2′-deoxyuridine (BrdU) labeling of newly synthesized genomes. We propose that HAART/PI represent a novel class of co-factors that modulate HPV infection of the target epithelium. Our in vitro tissue culture model is an important tool to study the mechanistic role of anti-retroviral drugs in promoting HPV infections in HAART-naïve primary epithelium. Changes in subsequent viral load could promote new infections, create HPV reservoirs that increase virus persistence, and increase the risk of oral and cervical cancer development in HIV-positive patients undergoing long-term HAART treatment.
Comment on: Jilkova, Z.M.; et al. “Predictive Factors for Response to PD-1/PD-L1 Checkpoint Inhibition in the Field of Hepatocellular Carcinoma: Current Status and Challenges” Cancers 2019, 11, 1554
Authors: Dunnigan Anna
Published: September 2020

I read with interest the article ‘Predictive Factors for Response to PD-1/PD-L1 Checkpoint Inhibition in the Field of Hepatocellular Carcinoma: Current Status and Challenges’ [...]
The Pancreatic Microbiome is Associated with Carcinogenesis and Worse Prognosis in Males and Smokers
Authors: Chakladar Jaideep , Kuo Selena Z. , Castaneda Grant , Li Wei Tse , Gnanasekar Aditi , Yu Michael Andrew , Chang Eric Y. , Wang Xiao Qi , Ongkeko Weg M.
Published: September 2020

An intra-pancreatic microbiota was recently discovered in several prominent studies. Since pancreatic adenocarcinoma (PAAD) is one of the most lethal cancers worldwide, and the intratumor microbiome was found to be a significant contributor to carcinogenesis in other cancers, this study aims to characterize the PAAD microbiome and elucidate how it may be associated with PAAD prognosis. We further explored the association between the intra-pancreatic microbiome and smoking and gender, which are both risk factors for PAAD. RNA-sequencing data from The Cancer Genome Atlas (TCGA) were used to infer microbial abundance, which was correlated to clinical variables and to cancer and immune-associated gene expression, to determine how microbes may contribute to cancer progression. We discovered that the presence of several bacteria species within PAAD tumors is linked to metastasis and immune suppression. This is the first large-scale study to report microbiome-immune correlations in human pancreatic cancer samples. Furthermore, we found that the increased prevalence and poorer prognosis of PAAD in males and smokers are linked to the presence of potentially cancer-promoting or immune-inhibiting microbes. Further study into the roles of these microbes in PAAD is imperative for understanding how a pro-tumor microenvironment may be treated to limit cancer progression.
Palladium PEPPSI-IPr Complex Supported on a Calix[8]arene: A New Catalyst for Efficient Suzuki–Miyaura Coupling of Aryl Chlorides
Authors: Labattut Axel , Abdellah Ibrahim , Buendia Julien , Abi Fayssal Sandra , Adhel Erika , Dragoe Diana , Martini Cyril , Schulz Emmanuelle , Huc Vincent
Published: September 2020

We report here the synthesis and characterization of a new calix[8]arene-supported PEPPSI-IPr Pd polymetallic complex. This complex, showing greater steric hindrance around the Pd centers compared with previous calix[8]arene-based catalysts, demonstrated high reactivity and selectivity for the Suzuki–Miyaura coupling of aryl chlorides under mild conditions. Along with this good performance, the new catalyst showed low Pd leaching into the final Suzuki–Miyaura coupling products, indicative of a heterogeneous-type reactivity. This rare combination of good reactivity towards challenging substrates and low metal leaching offers great promise at both academic and industrial levels.
Reverse Water Gas Shift by Chemical Looping with Iron-Substituted Hexaaluminate Catalysts
Authors: Utsis Natalie , Landau Miron V. , Erenburg Alexander , Herskowitz Moti
Published: September 2020

The Fe-substituted Ba-hexaaluminates (BaFeHAl) are active catalysts for reverse water-gas shift (RWGS) reaction conducted in chemical looping mode. Increasing of the degree of substitution of Al3+ for Fe3+ ions in co-precipitated BaHAl from 60% (BaFeHAl) to 100% (BaFe-hexaferrite, BaFeHF), growing its surface area from 5 to 30 m2/g, and promotion with potassium increased the CO capacity in isothermal RWGS-CL runs at 350–450 °C, where the hexaaluminate/hexaferrite structure is stable. Increasing H2-reduction temperature converts BaFeHAl to a thermally stable BaFeHF modification that contains additional Ba-O-Fe bridges in its structure, reinforcing the connection between alternatively stacked spinel blocks. This material displayed the highest CO capacity of 400 µmol/g at isothermal RWGS-CL run conducted at 550 °C due to increased concentration of oxygen vacancies reflected by greater surface Fe2+/Fe3+ ratio detected by XPS. The results demonstrate direct connection between CO capacity measured in RWGS-CL experiments and calculated CO2 conversion.
Seeking and Exploring Efficient Ways to Target Cancer
Authors: Kallunki Tuula
Published: September 2020

Anti-cancer treatments have never been so numerous and so efficient [...]
Tribology of 2D Nanomaterials: A Review
Authors: Uzoma Paul C. , Hu Huan , Khadem Mahdi , Penkov Oleksiy V.
Published: September 2020

The exfoliation of graphene has opened a new frontier in material science with a focus on 2D materials. The unique thermal, physical and chemical properties of these materials have made them one of the choicest candidates in novel mechanical and nano-electronic devices. Notably, 2D materials such as graphene, MoS2, WS2, h-BN and black phosphorus have shown outstanding lowest frictional coefficients and wear rates, making them attractive materials for high-performance nano-lubricants and lubricating applications. The objective of this work is to provide a comprehensive overview of the most recent developments in the tribological potentials of 2D materials. At first, the essential physical, wear and frictional characteristics of the 2D materials including their production techniques are discussed. Subsequently, the experimental explorations and theoretical simulations of the most common 2D materials are reviewed in regards to their tribological applications such as their use as solid lubricants and surface lubricant nano-additives. The effects of micro/nano textures on friction behavior are also reviewed. Finally, the current challenges in tribological applications of 2D materials and their prospects are discussed.
Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study
Authors: Paternò Gianfranco , Cardarelli Paolo , Gambaccini Mauro , Taibi Angelo
Published: September 2020

It has been long recognized that dual-energy imaging could help to enhance the detectability of lesions in diagnostic radiology, by removing the contrast of surrounding tissues. Furthermore, X-ray attenuation is material specific and information about the object constituents can be extracted for tissue characterisation, i.e., to assess whether lesions represent a malignant or benign process. However, a true separation between the low and high energy components is not possible with conventional sources because of their broad X-ray spectrum, and the artifacts produced in the subtracted image can be only partially removed. Finally, dose issues have also prevented so far the application of dual-energy techniques within the clinical context. Very recently, a new intense and monochromatic X-ray source was proposed to fill the gap between a synchrotron radiation facility and the standard X-ray tube. Indeed, inverse Compton scattering (ICS) sources, which are based on the interaction of a powerful laser beam and a bright beam of relativistic electrons, are among the most promising innovative sources of monochromatic X and gamma radiation. In this contribution, we review the main features that allow an ICS source to meet the requirements of a medical imaging application. Specific examples of K-edge subtraction are then provided, to show the potential of ICS in clinical applications that require intravenous injection of a contrast medium.
Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation
Authors: Ropers Fabienne G. , van Mossevelde Robin M. P. , Bleeker-Rovers Chantal P. , van Velden Floris H. P. , van Assema Danielle M. E. , Adam Judit A. , Lam Marnix G. E. H. , Tolboom Nelleke , Dekkers Olaf M. , de Geus-Oei Lioe-Fee , Frings Virginie
Published: September 2020

[18F]-FDG-PET/CT ([18F]-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)) is increasingly used as a diagnostic tool in suspected infectious or inflammatory conditions. Studies on the value of FDG-PET/CT in children are scarce. This study assesses the role of FDG-PET/CT in suspected infection or inflammation in children. In this multicenter cohort study, 64 scans in 59 children with suspected infection or inflammation were selected from 452 pediatric FDG-PET/CT scans, performed in five hospitals between January 2016 and August 2017. Main outcomes were diagnostic information provided by FDG-PET/CT for diagnostic scans and impact on clinical management for follow-up scans. Of these 64 scans, 50 were performed for primary diagnosis and 14 to monitor disease activity. Of the positive diagnostic scans, 23/27 (85%) contributed to establishing a diagnosis. Of the negative diagnostic scans, 8/21 (38%) contributed to the final diagnosis by narrowing the differential or by providing information on the disease manifestation. In all follow-up scans, FDG-PET/CT results guided management decisions. CRP was significantly higher in positive scans than in negative scans (p = 0.004). In 6% of diagnostic scans, relevant incidental findings were identified. In conclusion, FDG-PET/CT performed in children with suspected infection or inflammation resulted in information that contributed to the final diagnosis or helped to guide management decisions in the majority of cases. Prospective studies assessing the impact of FDG-PET/CT results on diagnosis and patient management using a structured diagnostic protocol are feasible and necessary.
FischerLab: An Application for Generating Fischer Plots and Dynamic Fischer Plots from Wireline Well-Logs and Stratigraphic Data
Authors: Amosu Adewale , Imsalem Mohamed , Raymond Anne , Sun Yuefeng
Published: September 2020

Fischer plots are a technique that is used to graph changes in accommodation in cyclic carbonate successions. They typically depict the cumulative departure from the average cycle thickness as a function of the cycle number or stratigraphic depth. Many applications of Fischer plots focus on their construction from exposed cyclic carbonate successions. No published programs allow the direct construction of Fischer plots from digital wireline well-logs or dynamic presentations of Fischer plots. Here, we introduce a program known as FischerLab, which facilitates the generation and analysis of Fischer plots. In addition to accepting interpreted stratigraphic data input, FischerLab facilitates the interpretation of digital wireline logs for the generation of Fischer plots in cycle and depth domains, as well as in a dynamic evolving cycle and relative depth domain from an easy-to-use interface. The dynamic construction facilitates the correlation of specific stratigraphic packages to parts of the accommodation cycle while simultaneously tracking the locus of the mean subsidence vector. We demonstrate the use of FischerLab on data derived from the carbonate succession outcrops of the Al-Athrun Formation, Libya, and the Glen Rose Formation, Central Texas, USA, as well as on wireline well-log data from the Western Great Bahama Bank, the Bahamas.
A Noniterative Radix-8 CORDIC Algorithm with Low Latency and High Efficiency
Authors: Tang Wenming , Xu Feng
Published: September 2020

An efficient, noniterative Radix-8 (NR-8) coordinate rotation digital computer (CORDIC) algorithm is proposed for low-latency and high-efficiency computation of the functions of sine, cosine, or the phase shift, with which the values of the functions are precisely computed by only using the angle in a narrow range of [0, π/12] rather than in a wide angle range of [0, π/2]. This algorithm is expressed by a formula that simplifies the traditional iterative processes by using a complex multiplier. The results obtained from the simulation and the experiment on an FPGA show that the NR-8 CORDIC algorithm operates well, with which the 16-bit precision output is extremely precise, with only 0.012% of the absolute error for computing the sine or cosine function with a step of 0.001°. Compared with the best conventional CORDIC algorithm, the clock latency of this algorithm significantly decreases down to less than 50%, only needs half of the logic resources and consumes half of the power. This algorithm also takes advantages over other newly improved CORDIC algorithms and requires less than half of the clock latency, even for a 23-bit precision output. Therefore, this algorithm could provide a potential application in real-time systems such as radar digital beamforming.
Evaluation of Scenedesmus rubescens for Lipid Production from Swine Wastewater Blended with Municipal Wastewater
Authors: Utomo Joseph Christian , Kim Young Mo , Cho Hyun Uk , Park Jong Moon
Published: September 2020

This study examined the feasibility of using non-sterilized swine wastewater for lipid production by an isolated microalga, Scenedesmus rubescens. Different dilution ratios using municipal wastewater as a diluent were tested to determine the suitable levels of microalgal growth in the wastewaters, its nutrient removal, and its lipid production. The highest lipid productivity (8.37 mg/L/d) and NH4+ removal (76.49%) were achieved in swine wastewater that had been diluted to 30 times using municipal wastewater. Various bacteria coexisted in the wastewaters during the cultivation of S. rubescens. These results suggest the practical feasibility of a system to produce lipids from swine wastewater by using microalgae.
An Artificial Intelligence Approach to Predict Gross Primary Productivity in the Forests of South Korea Using Satellite Remote Sensing Data
Authors: Lee Bora , Kim Nari , Kim Eun-Sook , Jang Keunchang , Kang Minseok , Lim Jong-Hwan , Cho Jaeil , Lee Yangwon
Published: September 2020

Many process-based models for carbon flux predictions have faced a wide range of uncertainty issues. The complex interactions between the atmosphere and the forest ecosystems can lead to uncertainties in the model result. On the other hand, artificial intelligence (AI) techniques, which are novel methods to resolve complex and nonlinear problems, have shown a possibility for forest ecological applications. This study is the first step to present an objective comparison between multiple AI models for the daily forest gross primary productivity (GPP) prediction using satellite remote sensing data. We built the AI models such as support vector machine (SVM), random forest (RF), artificial neural network (ANN), and deep neural network (DNN) using in-situ observations from an eddy covariance (EC) flux tower and satellite remote sensing data such as albedo, aerosol, temperature, and vegetation index. We focused on the Gwangneung site from the Korea Regional Flux Network (KoFlux) in South Korea, 2006–2015. As a result, the DNN model outperformed the other three models through an intensive hyperparameter optimization, with the correlation coefficient (CC) of 0.93 and the mean absolute error (MAE) of 0.68 g m−2 d−1 in a 10-fold blind test. We showed that the DNN model also performed well under conditions of cold waves, heavy rain, and an autumnal heatwave. As future work, a comprehensive comparison with the result of process-based models will be necessary using a more extensive EC database from various forest ecosystems.
Geographic Variations of the Wood Density and Fiber Dimensions of the Persian Oak Wood
Authors: Nazari Noorollah , Bahmani Mohsen , Kahyani Saleh , Humar Miha , Koch Gerald
Published: September 2020

Persian oak (Quercus brantii Lindl.) is a valuable native species in Iranian forests with very limited availability of data on its wood properties. The objective of the current study was to determine the influence of altitude and slope on physical properties and fiber dimensions of Persian oak wood. In addition, the relationship among wood properties, site conditions (temperature and rainfall) and growth traits of trees (tree height, DBH, basal area, age, crown diameter, crown basal area, volume and annual diameter increment) were studied by principal component analysis (PCA). Three altitude levels (1730, 1980 and 2250 m) and three slope classes (<30%, 30–45% and >45%) were considered in the current study. It was determined that trees growing in the intermediate altitude (1980 m) showed the highest oven-dry density values, and those in the lowest altitude (1730 m) revealed the lowest ones. The results also indicate significant statistical differences between altitude levels and slope classes on the fiber length, fiber diameter and volumetric swelling at the 99% confidence interval while no significant differences were found between average values of oven-dry density among different altitudes and slopes. PCA analysis indicated that altitude and temperature are the most important factors affecting the wood properties. Knowledge of the relationship between wood properties and environmental factors are essential in terms of both forestry management and wood applications.
A Permanent Research Platform for Ecological Studies in Intact Temperate Mountainous Forests from Slătioara UNESCO Site and Its Surroundings, Romania
Authors: Duduman Gabriel , Duduman Mihai-Leonard , Avăcăriței Daniel , Barnoaiea Ionuț , Barbu Cătălina-Oana , Ciornei Ioan , Clinovschi Florin , Coșofreț Vasile Cosmin , Cotos Mihai-Gabriel , Dănilă Gabriel , Dănilă Iulian-Constantin , Drăgoi Marian , Flocea Marcel-Neculai , Horodnic Sergiu-Andrei , Iacobescu Ovidiu , Mazăre Georgel Constantin , Măciucă Anca , Mursa Andrei , Palaghianu Ciprian , Pohonțu Corneliu Mihăiță , Roibu Cătălin-Constantin , Savin Alexei , Tomescu Cezar Valentin , Scriban Ramona-Elena
Published: September 2020

This paper describes a permanent research platform (PRP) designed and implemented in “Codrul secular Slătioara” and its surroundings (2205.85 ha), having also the role of introductory paper for future research articles based on data collected from this platform. “Codrul secular Slătioara” is known as one of the largest temperate mountainous intact forests of Europe and, in 2017, it was included in UNESCO World Heritage List, as part of the “Ancient and Primeval Beech Forests of the Carpathians and Other Regions of Europe”. Moreover, the PRP overlaps other three scientific reserves, the share of strictly protected forests exceeding 70%. This platform has a multiple role, being developed for research, conservation and educational activities. The PRP was designed for an ecological analysis of the intact forest ecosystems. It contains 193 circular sample plots, each of them of 500 m2, and it is structured on two levels. The first level contains 58 sample plots corresponding to a square grid of 500 × 500 m, stretching over the entire forested area, and the second level contains 135 plots, placed according to a square grid of 100 × 100 m, covering 136 ha within the core area of the UNESCO site. We measured the characteristics of 8296 living trees, 1743 standing dead trees, 1900 dead wood trunks, 3214 saplings, and the abundance–dominance indices of flora species. Thus, we identified 14 tree species, 17 shrub species, and 248 other cormophyte species forming the herbaceous layer. In terms of volume, the main tree species are Norway spruce, silver fir and European beech. The tallest species are Norway spruce (56 m) and silver fir (51 m). The average volume of living trees is 659 m3·ha−1, with a maximum of 1441 m3·ha−1. The mean total dead wood volume is about 158 m3·ha−1, with sample plots where the total dead wood volume exceeds 600 m3·ha−1. After presenting the results of preliminary data processing, the paper describes the main research topics to be further considered, based on the PRP, and the foresights related to the PRP’s monitoring and development.
A Hybrid CNN-LSTM Model for SMS Spam Detection in Arabic and English Messages
Authors: Ghourabi Abdallah , Mahmood Mahmood A. , Alzubi Qusay M.
Published: September 2020

Despite the rapid evolution of Internet protocol-based messaging services, SMS still remains an indisputable communication service in our lives until today. For example, several businesses consider that text messages are more effective than e-mails. This is because 82% of SMSs are read within 5 min., but consumers only open one in four e-mails they receive. The importance of SMS for mobile phone users has attracted the attention of spammers. In fact, the volume of SMS spam has increased considerably in recent years with the emergence of new security threats, such as SMiShing. In this paper, we propose a hybrid deep learning model for detecting SMS spam messages. This detection model is based on the combination of two deep learning methods CNN and LSTM. It is intended to deal with mixed text messages that are written in Arabic or English. For the comparative evaluation, we also tested other well-known machine learning algorithms. The experimental results that we present in this paper show that our CNN-LSTM model outperforms the other algorithms. It achieved a very good accuracy of 98.37%.
Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children
Authors: Ervina Ervina , Berget Ingunn , L. Almli Valérie
Published: September 2020

This study investigates the relationships between basic tastes and fattiness sensitivity and food liking in 11-year-old children. The basic taste sensitivity of 106 children was measured using different methods, namely detection (DT) and recognition (RT) thresholds, and taste responsiveness. Caffeine and quinine (bitter), sucrose (sweet), citric acid (sour), sodium chloride (salty), and monosodium glutamate (umami) were investigated for DT and RT at five concentrations in water solutions. In addition, taste responsiveness and liking were collected for the high-intensity concentrations. PROP (6-n-propylthiouracil) responsiveness was tested on paper strips. Fattiness sensitivity was measured by a paired comparison method using milk samples with varying fat content. Liking for 30 food items was recorded using a food-list questionnaire. The test was completed in a gamified “taste detective” approach. The results show that DT correlates with RT for all tastes while responsiveness to PROP correlates with overall taste responsiveness. Caffeine and quinine differ in bitterness responsiveness and liking. Girls have significantly lower DTs than boys for bitterness and sweetness. Food liking is driven by taste and fattiness properties, while fatty food liking is significantly influenced by fattiness sensitivity. These results contribute to a better holistic understanding of taste and fattiness sensitivity in connection to food liking in preadolescents.
Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients
Authors: Boyuk Banu , Saydan Dogukan , Mavis Osman , Erman Hande
Published: September 2020

Recent studies have shown a correlation between Helicobacter pylori (H. Pylori) infection and the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The aim of this study was to investigate the relationship between H. Pylori infection and hematimetric indices in patients with dyspepsia symptoms. Overall, 448 patients who underwent gastroscopy were analyzed retrospectively. Histopathological evaluation of biopsies according to H. pylori presence was classified as H. Pylori positive and negative groups, which are analyzed in relation with hematimetric indices. NLR and PLR measurements did not show a statistically significant difference between H. pylori negative and positive groups (p > 0.05). NLR revealed a negative correlation between hemoglobin (HGB), iron, and ferritin measurements in the correlation analysis of the H. Pylori positive group (r = −0.133, p = 0.031; r = −0.270, p = 0.002; r = −0.162, p = 0.032). Again, with PLR, there was a negative correlation between HGB, mean corpuscular volume (MCV), iron, and ferritin measurements (r = −0.310, p = 0.001, r = −0.187, p = 0.002, r = −0.335, p = 0.001; r = −0.290; p = 0.001). The results of our study do not reveal an association between H. pylori presence and inflammatory response, which is evaluated by NLR and PLR measurements in patients with dyspepsia. However, low serum iron and ferritin values of H. pylori-positive patients suggest the effect of H. pylori on iron metabolism.
Genomic Organization and Generation of Genetic Variability in the RHS (Retrotransposon Hot Spot) Protein Multigene Family in Trypanosoma cruzi
Authors: Bernardo Werica P. , Souza Renata T. , Costa-Martins André G. , Ferreira Eden R. , Mortara Renato A. , Teixeira Marta M. G. , Ramirez José Luis , Da Silveira José F.
Published: September 2020

Retrotransposon Hot Spot (RHS) is the most abundant gene family in Trypanosoma cruzi, with unknown function in this parasite. The aim of this work was to shed light on the organization and expression of RHS in T. cruzi. The diversity of the RHS protein family in T. cruzi was demonstrated by phylogenetic and recombination analyses. Transcribed sequences carrying the RHS domain were classified into ten distinct groups of monophyletic origin. We identified numerous recombination events among the RHS and traced the origins of the donors and target sequences. The transcribed RHS genes have a mosaic structure that may contain fragments of different RHS inserted in the target sequence. About 30% of RHS sequences are located in the subtelomere, a region very susceptible to recombination. The evolution of the RHS family has been marked by many events, including gene duplication by unequal mitotic crossing-over, homologous, as well as ectopic recombination, and gene conversion. The expression of RHS was analyzed by immunofluorescence and immunoblotting using anti-RHS antibodies. RHS proteins are evenly distributed in the nuclear region of T. cruzi replicative forms (amastigote and epimastigote), suggesting that they could be involved in the control of the chromatin structure and gene expression, as has been proposed for T. brucei.
The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases
Authors: Arora Itika , Sharma Manvi , Sun Liou Y. , Tollefsbol Trygve O.
Published: September 2020

Aging is a complex process mainly categorized by a decline in tissue, cells and organ function and an increased risk of mortality. Recent studies have provided evidence that suggests a strong association between epigenetic mechanisms throughout an organism’s lifespan and age-related disease progression. Epigenetics is considered an evolving field and regulates the genetic code at several levels. Among these are DNA changes, which include modifications to DNA methylation state, histone changes, which include modifications of methylation, acetylation, ubiquitination and phosphorylation of histones, and non-coding RNA changes. As a result, these epigenetic modifications are vital targets for potential therapeutic interventions against age-related deterioration and disease progression. Dietary polyphenols play a key role in modulating these modifications thereby delaying aging and extending longevity. In this review, we summarize recent advancements linking epigenetics, polyphenols and aging as well as critical findings related to the various dietary polyphenols in different fruits and vegetables. In addition, we cover studies that relate polyphenols and their epigenetic effects to various aging-related diseases such as cardiovascular diseases, neurodegenerative diseases, autoimmune disorders, diabetes, osteoporosis and cancer.
A Review of Tsunami Hazards in the Makran Subduction Zone
Authors: Rashidi Amin , Dutykh Denys , Shomali Zaher Hossein , Keshavarz Farajkhah Nasser , Nouri Mohammadsadegh
Published: September 2020

The uncertain tsunamigenic potential of the Makran Subduction Zone (MSZ) has made it an interesting natural laboratory for tsunami-related studies. This study aims to review the recent activities on tsunami hazard in the Makran subduction zone with a focus on deterministic and probabilistic tsunami hazard assessments. While almost all studies focused on tsunami hazard from the Makran subduction thrust, other local sources such as splay faults and landslides can be also real threats in the future. Far-field tsunami sources such as Sumatra-Andaman and Java subduction zones, commonly lumped as the Sunda subduction zone, do not seem to pose a serious risk to the Makran coastlines. The tsunamigenic potential of the western segment of the MSZ should not be underestimated considering the new evidence from geological studies and lessons from past tsunamis in the world. An overview of the results of tsunami hazard studies shows that the coastal area between Kereti to Ormara along the shoreline of Iran-Pakistan and the coastal segment between Muscat and Sur along Oman’s shoreline are the most hazardous areas. Uncertainties in studying tsunami hazard for the Makran region are large. We recommend that future studies mainly focus on the role of thick sediments, a better understanding of the plates interface geometry, the source mechanism and history of extreme-wave deposits, the contribution of other local tsunamigenic sources and vulnerability assessment for all coastlines of the whole Makran region.
Fighting Food Poverty through Film: Or Why Global Challenge Research Needs the Arts and Humanities
Authors: Topping Margaret
Published: September 2020

Food poverty is just one example of a global challenge where the Arts and Humanities perspective risks being judged at worst to have no relevance at all, and at best to be included as no more than an accessible tool to facilitate public engagement and awareness-raising. How therefore can Arts and Humanities scholars articulate the value of their work in such a way that researchers in other fields are persuaded not only that it brings something new to their understanding of the issues, but that to tackle such questions without this input would leave a significant methodological gap in developing the pathway to research impact? The present discussion takes as its central case study an analysis of the strategies at play to tackle the question of food poverty in French filmmaker Agnès Varda’s 2000 film, Les Glaneurs et la glaneuse [The Gleaners and I]. It then uses this analysis as a springboard to explore how, as Arts and Humanities scholars, we might begin to translate better our methodologies and the unique power of our objects of study to disciplines which tend to dominate research on food security, poverty and sustainability or indeed other challenge-based research. To this end, the present discussion seeks to decipher the power of this methodology in terms of the unique capacity for ‘affect’ of the work of art, and ultimately argues for the essential contribution of Arts and Humanities researchers as ‘brokers’ for movement building and social change.
Effect of Soil Geomechanical Properties and Geo-Environmental Factors on Landslide Predisposition at Mount Oku, Cameroon
Authors: Djukem Wamba Danny Love , Braun Anika , Wouatong Armand Sylvain Ludovic , Guedjeo Christian , Dohmen Katrin , Wotchoko Pierre , Fernandez-Steeger Tomas Manuel , Havenith Hans-Balder
Published: September 2020

In this work, we explored a novel approach to integrate both geo-environmental and soil geomechanical parameters in a landslide susceptibility model. A total of 179 shallow to deep landslides were identified using Google Earth images and field observations. Moreover, soil geomechanical properties of 11 representative soil samples were analyzed. The relationship between soil properties was evaluated using the Pearson correlation coefficient and geotechnical diagrams. Membership values were assigned to each soil property class, using the fuzzy membership method. The information value method allowed computing the weight value of geo-environmental factor classes. From the soil geomechanical membership values and the geo-environmental factor weights, three landslide predisposition models were produced, two separate models and one combined model. The results of the soil testing allowed classifying the soils in the study area as highly plastic clays, with high water content, swelling, and shrinkage potential. Some geo-environmental factor classes revealed their landslide prediction ability by displaying high weight values. While the model with only soil properties tended to underrate unstable and stable areas, the model combining soil properties and geo-environmental factors allowed a more precise identification of stability conditions. The geo-environmental factors model and the model combining geo-environmental factors and soil properties displayed predictive powers of 80 and 93%, respectively. It can be concluded that the spatial analysis of soil geomechanical properties can play a major role in the detection of landslide prone areas, which is of great interest for site selection and planning with respect to sustainable development at Mount Oku.
Latent Health Risk Classes Associated with Poor Physical and Mental Outcomes in Workers with COPD from Central Appalachian U.S. States
Authors: Stellefson Michael , Wang Min Qi , Balanay Jo Anne G. , Wu Rui , Paige Samantha R.
Published: September 2020

Adults who work in the Central Appalachian region of the United States (U.S.) are disproportionately affected by Chronic Obstructive Pulmonary Disease (COPD). While there is a socio-demographic profile of adults with COPD who are at increased risk for physical and mental distress, the risk factors that uniquely affect the health-related quality of life (HRQoL) of Central Appalachian workers with COPD are unknown. Therefore, we conducted a latent class analysis of 2016 and 2017 Behavioral Risk Factor Surveillance System data from 1326 currently employed adults with COPD living in four U.S. states (KY, NC, TN, and WV) within the Central Appalachian Region. Drawing from the social ecological model, we identified associations between theoretically informed risk indicators—comorbid health conditions, substance use and abuse, and limited access to healthcare—on three HRQoL variables, including infrequent (0–13 days) or frequent (≥14 days) physical distress, mental distress, and limited activity due to poor health over the past 30 days. Workers at high risk for comorbid conditions reported more frequent physical distress, mental distress, and activity limitations as compared to those at low risk. Workers reporting difficulty accessing healthcare were no more likely to report physical or mental distress when compared to workers with adequate access to healthcare; however, those with limited healthcare access did report more frequent activity limitation due to poor health. Interestingly, workers with COPD at high risk for substance use and abuse were no more likely to report poor HRQoL outcomes compared to those at low risk. Our findings have important implications for addressing indicators of poor health among Central Appalachian workers with COPD, especially those living with multiple comorbidities.
Sustainable Development and Crude Oil Revenue: A Case of Selected Crude Oil-Producing African Countries
Authors: Ologunde Ifeoluwa Adeola , Kapingura Forget Mingiri , Sibanda Kin
Published: September 2020

This study investigated the relationship between sustainable development and crude oil revenue (COR) in selected oil-producing African countries from 1992–2017 using the Pooled Mean Group (PMG) estimators on panel autoregressive distributed lag model (ARDL). Sustainable development was measured with the Human Development Index (HDI). This study was significant for Africa to break away from fiscal over-dependence on natural resource revenue, especially crude oil due to its high volatility and to correct porous institutional outlook. The a priori expectation is that crude oil revenue will tank so much that many countries will record negative positions and might not be to meet fiscal demands in the long run if the situation is protracted. Empirical results revealed that there was no long-term relationship between COR and sustainable development. In other words, the results suggest that any changes to COR have a potential negative effect on sustainable development in the selected countries. This implies over-reliance on COR will impact the economies negatively in the long run. This finding, therefore, requires an immediate fiscal intervention on spending on sustainable development drivers such as education, health, agriculture cum adoption diversification policy, and veritable supply-side policies that could avert the possibility of these negative effects and to correct traits of ineffective public institution. The absence of such policy interventions in these countries seems to be related to ineffective public institution and bad governance, culminating from poor, ineffective, and inefficient implementation.
Elements of Effective Population Surveillance Systems for Monitoring Obesity in School Aged Children
Authors: Hardy Louise L. , Mihrshahi Seema
Published: September 2020

The continuing high prevalence of child overweight and obesity globally means that it remains the most common chronic health condition in children. Population-based child obesity surveillance systems are critical for monitoring trends in obesity and related behaviours, and determining the overall effect of child obesity prevention strategies. Effective surveillance systems may vary in methods, scope, purpose, objectives, and attributes, and our aim was to provide an overview of child obesity surveillance systems globally, and to highlight main components and other types of survey data that can enhance our understanding of child obesity. Measures of adiposity, including body mass index and waist circumference are essential, but effective surveillance must also include measures of weight-related behaviours, including diet, physical activity, sedentary time, and sleep. While objective measures are desirable, the variability in psychometrics and rapid evolution of wearable devices is potentially problematic for examining long-term trends over time and how behaviours may change. Questionnaires on self-reported behaviours are often used but also have limitations. Because the determinants of obesity are not only functioning at the individual level, some measures of the broader environmental and commercial determinants, including the built and food environments, are useful to guide upstream policy decisions.
Effect of Urban Wastewater Discharge on the Abundance of Antibiotic Resistance Genes and Antibiotic-Resistant Escherichia coli in Two Italian Rivers
Authors: Pantanella Fabrizio , Lekunberri Itziar , Gagliardi Antonella , Venuto Giuseppe , Sànchez-Melsió Alexandre , Fabiani Massimo , Balcázar José Luis , Schippa Serena , De Giusti Maria , Borrego Carles , Solimini Angelo
Published: September 2020

Background: Wastewater treatment plants (WWTPs) are microbial factories aimed to reduce the amount of nutrients and pathogenic microorganisms in the treated wastewater before its discharge into the environment. We studied the impact of urban WWTP effluents on the abundance of antibiotic resistance genes (ARGs) and antibiotic-resistant Escherichia coli (AR-E. coli) in the last stretch of two rivers (Arrone and Tiber) in Central Italy that differ in size and flow volume. Methods: Water samples were collected in three seasons upstream and downstream of the WWTP, at the WWTP outlet, and at sea sites near the river mouth, and analyzed for the abundance of ARGs by qPCR and AR-E. coli using cultivation followed by disk diffusion assays. Results: For all studied genes (16S rRNA, intI1, sul1, ermB, blaTEM, tetW and qnrS), absolute concentrations were significantly higher in the Tiber than in the Arrone at all sampling sites, despite their collection date, but the prevalence of target ARGs within bacterial communities in both rivers was similar. The absolute concentrations of most ARGs were also generally higher in the WWTP effluent with median levels between log 4 and log 6 copies per ml but did not show differences along the studied stretches of rivers. Statistically significant site effect was found for E. coli phenotypic resistance to tetracycline and ciprofloxacin in the Arrone but not in the Tiber. Conclusions: In both rivers, diffuse or point pollution sources other than the studied WWTP effluents may account for the observed resistance pattern, although the Arrone appears as more sensitive to the wastewater impact considering its lower flow volume.
WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry
Authors: Blake Holly , Somerset Sarah , Whittingham Katharine , Middleton Matthew , Yildirim Mehmet , Evans Catrin
Published: September 2020

Interprofessional learning (IPL) is essential to prepare healthcare trainees as the future public health workforce. WHIRL (Workplace Health InteRprofessional Learning) was an innovative IPL intervention that engaged volunteer healthcare trainees (n = 20) in multi-professional teams to deliver health checks (n = 464), including tailored advice and signposting, to employees in the UK construction industry (across 21 events, 16 sites, 10 organisations) as part of an ongoing research programme called Test@Work. Volunteers undertook a four-part training and support package of trainer-led education, observations of practice, self-directed learning and clinical supervision, together with peer mentoring. In a one-group post-test only design, IPL outcomes were measured using the Inventory of Reflective Vignette-Interprofessional Learning (IRV-IPL), and the psychometric properties of the IRV-IPL tool were tested. WHIRL demonstrably improved healthcare trainees’ interprofessional skills in all five areas of collaboration, coordination, cooperation, communication, and commendation. The IRV-IPL tool was found to be a valid and reliable measure of interprofessional competencies across three scenarios; before and after health promotion activities, and as a predictor of future health promotion competence. This industry-based workplace IPL programme resulted in the attainment of health check competencies and bridged the gap between research, education and clinical practice.
Research on the Comfort of Vehicle Passengers Considering the Vehicle Motion State and Passenger Physiological Characteristics: Improving the Passenger Comfort of Autonomous Vehicles
Authors: Wang Chang , Zhao Xia , Fu Rui , Li Zhen
Published: September 2020

Comfort is a significant factor that affects passengers’ choice of autonomous vehicles. The comfort of an autonomous vehicle is largely determined by its control algorithm. Therefore, if the comfort of passengers can be predicted based on factors that affect comfort and the control algorithm can be adjusted, it can be beneficial to improve the comfort of autonomous vehicles. In view of this, in the present study, a human-driven experiment was carried out to simulate the typical driving state of a future autonomous vehicle. In the experiment, vehicle motion parameters and the comfort evaluation results of passengers with different physiological characteristics were collected. A single-factor analysis method and binary logistic regression analysis model were used to determine the factors that affect the evaluation results of passenger comfort. A passenger comfort prediction model was established based on the bidirectional long short-term memory network model. The results demonstrate that the accuracy of the passenger comfort prediction model reached 84%, which can provide a theoretical basis for the adjustment of the control algorithm and path trajectory of autonomous vehicles.
Differences in Body Composition across Police Occupations and Moderation Effects of Leisure Time Physical Activity
Authors: Kukić Filip , Heinrich Katie M. , Koropanovski Nenad , Poston Walker S. C. , Čvorović Aleksandar , Dawes J. Jay , Orr Robin , Dopsaj Milivoj
Published: September 2020

This study investigated differences in the body composition of police officers from different occupational groups and the moderation effects of leisure time physical activity (LTPA). A sample of 237 police officers (special anti-terrorist unit, gendarmerie, firefighters, and general duties) participated in the study. Body mass index (BMI), percent of body fat (%BF), percent of skeletal muscle mass (%SMM), and index of hypokinesia (IH) were assessed using a multichannel bioelectric impedance analyzer and officers reported the amount of LTPA using an international physical activity questionnaire. The sample was divided in three groups relative to LTPA, sedentary (0–149 min/week), moderately active (150–299 min/week), and very active (300+ min/week). Multiple analysis of variance (4 × 3) was used to analyze if occupational groups differed based solely on occupation, if officers from the same occupation differed in muscularity and fatness based on LTPA, and if any differences in body composition occurred between officers from different occupations with the same level of LTPA. Police officers from more physically demanding occupations demonstrated lower %BF and IH, while having higher %SMM. This was also observed among the officers of the same occupation who reported a higher LTPA, while officers who reported very high LTPA had similar body composition.