bluuebunny/crossref_metadata_2025 huggingface dataset:
The implementation of NILS: A web-based artificial neural network decision support tool for noninvasive lymph node staging in breast cancer
Authors: Dihge Looket , Bendahl Pär-Ola , Skarping Ida , Hjärtström Malin , Ohlsson Mattias , Rydén Lisa
Published: March 2023

Objective

To implement artificial neural network (ANN) algorithms for noninvasive lymph node staging (NILS) to a decision support tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis.

Methods

The NILS tool is a further development of an ANN prototype for the prediction of nodal status. Training and internal validation of the original algorithm included 15 clinical and tumor-related variables from a consecutive cohort of 800 breast cancer cases. The updated NILS tool included 10 top-ranked input variables from the original prototype. A workflow with four ANN pathways was additionally developed to allow different combinations of missing preoperative input values. Predictive performances were assessed by area under the receiver operating characteristics curves (AUC) and sensitivity/specificity values at defined cut-points. Clinical utility was presented by estimating possible sentinel lymph node biopsy (SLNB) reduction rates. The principles of user-centered design were applied to develop an interactive web-interface to predict the patient’s probability of healthy lymph nodes. A technical validation of the interface was performed using data from 100 test patients selected to cover all combinations of missing histopathological input values.

Results

ANN algorithms for the prediction of nodal status have been implemented into the web-based NILS tool for personalized, noninvasive nodal staging in breast cancer. The estimated probability of healthy lymph nodes using the interface showed a complete concordance with estimations from the reference algorithm except in two cases that had been wrongly included (ineligible for the technical validation). NILS predictive performance to distinguish node-negative from node-positive disease, also with missing values, displayed AUC ranged from 0.718 (95% CI, 0.687-0.748) to 0.735 (95% CI, 0.704-0.764), with good calibration. Sensitivity 90% and specificity 34% were demonstrated. The potential to abstain from axillary surgery was observed in 26% of patients using the NILS tool, acknowledging a false negative rate of 10%, which is clinically accepted for the standard SLNB technique.

Conclusions

The implementation of NILS into a web-interface are expected to provide the health care with decision support and facilitate preoperative identification of patients who could be good candidates to avoid unnecessary surgical axillary staging.
A national survey of individualized pharmaceutical care practice in Chinese hospitals in 2019
Authors: Cai Mingyuan , Zhou Liang , Gao Daihui , Mei Dan , Zhang Bo , Zuo Wei , Yan Qing
Published: March 2023

Background: Individualized pharmaceutical care, which consists of therapeutic drug monitoring (TDM), pharmacogenetic (PGx) testing and pharmacist-managed clinic (PMC), is one of the most important trends in clinical pharmacy development in the future. While relevant studies in China were primarily single-center or regional. This study aims to explore the current status of individualized pharmaceutical care in China, find out the existing problems and provide references for its further development.

Methods: An electronic questionnaire was used and national hospitals’ pharmaceutical administration data from January to December 2019 were collected. The data were sorted into Excel for further statistical analysis. All analyses were descriptive.

Results: The proportions of hospitals that performed TDM and PGx testing were 12.83% and 9.48%, respectively. The major responsible departments were the clinical laboratory and pharmacy department. External quality control was carried out in around 70% of hospitals for both TDM and PGx testing. More than half of hospitals provided TDM services for valproate sodium, digoxin, carbamazepine, vancomycin and cyclosporine. And an average of 6.84 drugs were performed TDM in 540 hospitals. Clopidogrel and warfarin were the top two drugs that performed PGx testing. As for the PMC, 10.03% of hospitals opened PMC, of which 60.00% had independent PMC. Approximately 80% of PMC services were free of charge.

Conclusion: The development of individualized pharmaceutical care in China is still in the early stage. Different sectors have to coalesce to promote its implementation, including the appropriate education, coverage, reimbursement policies, high-quality evidence, data systems, health system processes and health policies, etc.
Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides
Authors: Widjaja Frances , Zheng Liang , Wesseling Sebastiaan , Rietjens Ivonne M. C. M.
Published: March 2023

Over 1,000 pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) occur in 3% of all flowering plants. PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into pyrrole intermediates that generate protein- and DNA-adducts resulting in liver toxicity and carcinogenicity. Literature data for senecionine N-oxide in rats indicate that the relative potency (REP) value of this PA-N-oxide compared to its parent PA senecionine varies with the endpoint used. The first endpoint was the ratio between the area under the concentration-time curve (AUC) for senecionine upon dosing senecionine N-oxide or an equimolar dose of senecionine, while the second endpoint was the ratio between the amount for pyrrole-protein adducts formed under these conditions. This study aimed to investigate the mode of action underlying this endpoint dependent REP value for senecionine N-oxide with physiologically based kinetic (PBK) modeling. Results obtained reveal that limitation of 7-GS-DHP adduct formation due to GSH depletion, resulting in increased pyrrole-protein adduct formation, occurs more likely upon high dose oral PA administration than upon an equimolar dose of PA-N-oxide. At high dose levels, this results in a lower REP value when based on pyrrole-protein adduct levels than when based on PA concentrations. At low dose levels, the difference no longer exists. Altogether, the results of the study show how the REP value for senecionine N-oxide depends on dose and endpoint used, and that PBK modeling provides a way to characterize REP values for PA-N-oxides at realistic low dietary exposure levels, thus reducing the need for animal experiments.
A prospective randomized comparative placebo-controlled double-blind study in two groups to assess the effect of the use of biologically active additives with Siberian fir terpenes for the biological age of a person
Authors: Maganova Faniya , Voevoda Mikhail , Popov Vladimir , Moskalev Alexey
Published: March 2023

A prospective randomized comparative placebo-controlled double-blind study was carried out based on Arterial Indices model of biological age. The study involved 60 men and women aged 40–65 years that were randomly divided into two equal groups of 30 people: the main group and the control one. The study participants from the main group received a dietary supplement containing Siberian fir terpenes, limonene, alpha-linolenic acid, and vitamin E—1 capsule 3 times a day for 90 days. Patients in the comparison group received a placebo according to a similar scheme. Anthropometric and biochemical characteristics of patients from both groups have not undergone any significant changes. According to ultrasound examination of the carotid arteries, we observed a statistically significant decrease in the minimum thickness of the intima-media complex (by 45%). The maximum carotid artery stenosis on the right or left and the expansion index in patients of both groups did not change significantly during treatment. According to the results of applanation tonometry, it was revealed that when taking the studied dietary supplement, the pulse wave velocity significantly decreased compared to the initial one (by 10%). Accordingly, the Arterial Indices biological age decreased by 2.5 years compared to the baseline level in patients of the main group and did not change in patients from the comparison group. Supplementation of fir terpenes in middle-aged patients of both sexes reduces the biological age reflecting the condition of the arteries.
Interoceptive sensibility differentiates the predictive pattern of emotional reactivity on depression
Authors: Huang Yun-Hsin , Huang Yu-Ting , Yen Nai-Shing
Published: March 2023

The role of emotional reactivity in the psychopathology of depression has been studied widely but not comprehensively. Inconsistencies in existing literature indicate the presence of other factors may affect this dynamic. An individual’s method of processing their physiological sensations is a third variable because emotions are psychophysiological. This study identified the predictiveness of ease of activation, intensity, and duration of negative and positive emotions on depressive symptoms differentiated by interoceptive sensibility (IS). A total of 270 community participants filled-in questionnaires assessing their IS, habitual emotional reactivity, depressive severity, and response bias. A two-step clustering analysis identified the IS characteristics. Negative and positive reactivity models among each IS cluster were tested using bootstrapping regression, controlling for gender and response bias. IS can be clustered into “high IS,” “low IS,” and “worriers.” Both positive and negative reactivity’s predictiveness patterns on depression were different between IS clusters. Lower positive reactivity predicted depression among individuals with low IS (harder to activate positive emotions) and worriers (shorter duration of positive emotions) but not among individuals with high IS. Those with high IS also exhibited the highest positive reactivity. Ease of activating negative emotions predicted depression among high IS individuals, and a longer duration of negative emotions predicted depression among worriers. IS may affect the psychopathology of depression through subjective emotional reactivity. Thus, IS characteristics can be incorporated into intervention plans.
The interaction of orthography, phonology and semantics in the process of second language learners’ Chinese character production
Authors: Zhang Linlin , Xing Hongbing
Published: March 2023

Theories of connectionism emphasize the mappings of orthography, phonology, and semantics in the process of word recognition and production. Chinese has a logographic writing system, which is markedly different from alphabetic languages. The current study investigated how orthography, phonology, and semantics contribute to Chinese character production among Chinese as a second language (CSL) learners. This study collected 33,856 Chinese characters in a sample of 2,116 CSL learners with 7 diverse L1s. ANOVA was conducted to examine the effect of Chinese character error type on 7 L1s and three Chinese proficiency levels. The results of ANOVA revealed that successful CSL learners’ Chinese character production was derived from connections between orthography, semantics, and phonology. Semantics, especially the orthography-semantics connection, was the key point for production skills. Furthermore, connectionist models of languages rather than language distance affected production. These findings indicate that Chinese character production is associated with not only orthographic knowledge but also representation mechanisms of orthography, phonology, and semantics between different language writing systems. The results contribute to a better understanding of literacy skills in CSL learners. Future research could further address how CSL learners transform perceptive skills into production skills and the correlation between reading and writing skills by examining and controlling other important cognitive variables.
How self-leadership promotes job crafting: Based on the perspective of self-determination theory
Authors: Liu Geng , Peng Huimin , Wen Hao
Published: March 2023

According to self-determination theory, the present study develops a moderated mediation model to investigate how and when self-leadership promotes employees’ job crafting, emphasizing the mediating effect of autonomous motivation and the moderating effect of leader empowering behavior. We analyze and test the hypotheses based on 269 valid three-wave data from employees. The findings show that self-leadership has a significantly positive impact on job crafting, and a positive indirect effect on job crafting via autonomous motivation. Furthermore, leader empowering behavior not only enhances the positive impact of self-leadership on autonomous motivation, but also positively moderates the mediating effect of autonomous motivation in the relationship between self-leadership and job crafting. Practically, our study provides insights into how to promote job crafting. We also propose limitations and directions for future research.
Organizational facilitators and barriers for participation in workplace health promotion in healthcare: A qualitative interview study among nurses
Authors: Bleier Hannah , Lützerath Jasmin , Schaller Andrea
Published: March 2023

Background

There is evidence for the positive effects of workplace health promotion (WHP) for nurses. Although this highly stressed target group also actively desires WHP, the number of participants is low. Individual reasons play a role in the decision to engage in WHP activities, yet it is interesting to consider which organizational factors a company could address to improve participation. In this regard, the question arises of what organizational factors facilitate participation in WHP activities from the perspective of nurses in inpatient care facility (ICF), outpatient care service (OCS), and acute care hospitals (ACH).

Method

Sixteen semi-structured interviews were conducted in different care settings between May and September 2021. Questions about everyday working life, WHP activities, and organizational framework conditions were asked.

Result

The results show that there is a wide range of influencing factors at the organizational level, some overall settings, and others setting-specific. High workload and the fit of WHP activities with shift times were particularly inhibiting overall settings. A negative association with the employer worked as a barrier in ICF and ACH.

Conclusion

When implementing WHP activities, it can be useful to consider organizational facilitators and barriers to promote sustainable and attractive WHP activities and higher participation rates in the different settings of nursing.
How do topics and emotions develop in elementary school children? A text mining perspective based on free-writing text over 6 years
Authors: Liu Mengjun , Jiang Xinyu , Zhang Bingbing , Song Ting , Yu Gang , Liu Guofang , Jiang Nan , Wu Di , Zhou Zhi
Published: March 2023

Free-text data with long duration and continuity have great potential for studying environmental concerns and emotional expressions in child development. Based on ecosystem theory, using topic modeling and sentiment analysis in text mining to mine 4556 free-text writing data from first to sixth grade in elementary school, this study aims to reveal concerned topics’ evolutionary trends and sentiment expression differences in topics during elementary school children’s development. The results show the following: (1) Children prefer to focus on the topics of school and family in elementary school; (2) With the growth of grades, the proportion of family topics continues to decline, while that of social culture topics keeps rising; (3) When describing school, family, social culture, and interest, children mostly express negative emotions, and when describing peers and ability they mostly express positive emotions; (4) As the grade increases, the emotional expression on social culture topics become negative, while that on ability and interest topics become positive, and there are more differences in emotion expression between topics in junior and senior elementary grades. Discussion and conclusion are discussed at the end.
Facilitation or inhibition? Impact of CEO’s financial background on industrial AI transformation of manufacturing companies
Authors: Xu Peng , Zhang Zichao
Published: March 2023

Introduction

The purpose of this paper is to empirically test the impact of CEO’s financial background on industrial AI transformation of manufacturing enterprises based on upper echelons theory and imprinting theory.

Methods

The paper preliminarily takes listed manufacturing companies in Shanghai and Shenzhen stock markets that are affiliated to enterprise groups from 2014 to 2020 as samples, and manually collects and collates datas of CEO’s financial background and industrial AI transformation. The research hypotheses are tested by stata 15.0 software.

Results

It is found that CEO’s financial background significantly inhibits the industrial AI transformation of manufacturing enterprises, and when the CEO works part-time in the parent company, it will strengthen the negative impact of CEO’s financial background on industrial AI transformation. Further research shows that enterprise financialization plays a partial intermediary role between CEO’s financial background and industrial AI transformation; Compared with private enterprise groups, the inhibiting effect of CEO financial background on industrial AI transformation is stronger in state-owned enterprise groups; CEOs with non-banking financial background have a stronger inhibitory effect on industrial AI transformation.

Discussion

Firstly, based on the process of making business decisions, it verifies and clarifies the action mechanism of CEO’s financial background on industrial AI transformation through internal driving mechanism, which expands the research horizon of industrial AI transformation, and further applies the Imprinting Theory in biology to the research of business decision-making, which forms a beneficial complement to the relevant research on economic consequences of CEO’s financial background. Secondly, different from the research of single independent company, this paper focuses on the special situation of parent-subsidiary corporate governance, and explores the mechanism of action, deepening the research on the synergy of enterprise groups. Finally, this paper further explores the influence of CEO’s financial background on industrial AI transformation, which is conducive to a deeper understanding of the heterogeneity of managers except manpower and capital factors in the industrial AI transformation practice of manufacturing enterprises, and provides a new idea and a more comprehensive analysis perspective for industrial AI transformation.
Adapting CBT for youth anxiety: Flexibility, within fidelity, in different settings
Authors: Kendall Philip C. , Ney Julia S. , Maxwell Colleen A. , Lehrbach Kyler R. , Jakubovic Rafaella J. , McKnight Dominique S. , Friedman Abbey L.
Published: March 2023

Anxiety disorders are common in youth, associated with impairments in daily functioning, and often persist into adulthood when untreated. Cognitive behavioral therapy (CBT) for youth anxiety is a well-established intervention and has been modified to fit several treatment settings. Despite decades of results supporting the efficacy of CBT, there is a large gap in access to this treatment and a need to consider how it can best be administered flexibly to increase uptake and personalization. We first discuss the core components of treatment for CBT through the lens of the Coping Cat treatment. Next, we review the empirical findings regarding adjustments made for CBT for youth anxiety delivered (a) in schools, (b) in community settings, (c) through telehealth, (d) through online computer programs, and (e) by caregivers at home. In each setting, we provide specific suggestions for how to implement CBT with flexibility while maintaining fidelity.
The role of early social play behaviors and language skills for shy children’s later internalizing difficulties in school
Authors: Baardstu Silje , Sette Stefania , Brandlistuen Ragnhild Eek , Wang Mari Vaage
Published: March 2023

Research has demonstrated links from early childhood shyness to socioemotional problems later in life. This longitudinal study explored the role of early social play behaviors and language skills in the associations between childhood shyness and later internalizing and language difficulties in school. Participants were N = 7,447 children (50.1% girls) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). Latent direct, indirect, and interaction path analyses were performed within a structural equation framework. Results showed that mother-rated childhood shyness from age 18 months to age five years was associated with mother-rated internalizing difficulties and language problems at age eight years. Lower levels of teacher-reported social play behaviors and poorer language skills in preschool increased the risk of later anxiety problems among shy children, whereas higher levels of language competencies and social play behaviors buffered against later anxiety problems. The study identifies some of the early risk and protective factors that may influence shy children’s socio-emotional functioning and adjustment.
Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development
Authors: Gao Qian , Sun Wei , Wang Yue-Rui , Li Zi-Fa , Zhao Feng , Geng Xi-Wen , Xu Kai-Yong , Chen Dan , Liu Kun , Xing Ying , Liu Wei , Wei Sheng
Published: March 2023

Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress sensitivity due to the fluctuation of hormone level in luteal phase of the menstrual cycle. In this review, we describe the emotional regulatory effect of allopregnanolone (ALLO), and summarize the relationship between ALLO and γ-aminobutyric acid A (GABAA) receptor subunits based on rodent experiments and clinical observations. A rapid decrease in ALLO reduces the sensitivity of GABAA receptor, and reduces the chloride influx, hindered the inhibitory effect of GABAergic neurons on pyramidal neurons, and then increased the excitability of pyramidal neurons, resulting in PMDD-like behavior. Finally, we discuss in depth the treatment of PMDD with targeted GABAA receptors, hoping to find a precise target for drug development and subsequent clinical application. In conclusion, PMDD pathophysiology is rooted in GABAA receptor sensitivity changes caused by rapid changes in ALLO levels. Targeting GABAA receptors may alleviate the occurrence of PMDD.
Intermittent water supply and self-rated health in rural China's karst region
Authors: Wu Guoyong , Cheng Jianwei , Yang Fan , Riaz Noman
Published: March 2023

Introduction

With rapid economic and social development, surging demand for domestic water, and the increasing shortage of water resources, the applications of intermittent water supply systems have become more common in rural China and other developing countries. The accompanying hygiene risks require our more attention.

Methods

Based on the Grossman model, this paper conducted an IV-Oprobit model to investigate whether and how intermittent water supply affect rural residents' self-rated health status. Our data came from “China Karst Rural Economic Survey (CKRS)”, which covers 8 provinces and 641 villages in rural China's karst region.

Results and discussion

We found that: (1) Intermittent water supply has adverse effects on the self-rated health status of rural residents. Compared with the rural residents under continuous water supply, the probability of “fair” health status under intermittent water supply significantly increases by 18.2%, while the probability of “excellent” significantly reduces by 58.8%. (2) Residents' water storage behavior and sanitary water habit are important mechanisms for intermittent water supply to affect residents' self-rated health status; (3) Intermittent water supply has a greater impact on the self-rated health of females and the groups with lower education levels. The results of our study have the following policy implications: relevant departments should make a rational plan about water supply methods and improve related supporting measures; we should strengthen health education for rural residents on water behavior to standardize their water storage and sanitary water behavior; government should enhance the pertinence of policy implementation and favor specific measures to specific populations.
Knowledge, attitude, and practices on COVID-19 prevention and diagnosis among medical workers in the radiology department: A multicenter cross-sectional study in China
Authors: Sun Qiyuan , Yu Chunyan , Zheng Zhedong , Wu Qiong , Zhang Jian , Jiang Peng , Liu Ying
Published: March 2023

Objective

The aim of this study was to investigate the knowledge, attitude, and practice (KAP) of medical workers in the radiology department toward the prevention and diagnosis of COVID-19.

Methods

This multicenter cross-sectional study was conducted among medical workers in the radiology department of 17 hospitals between March and June 2022.

Results

A total of 324 medical workers were enrolled. The mean knowledge scores were 15.3 ± 3.4 (out of 23), attitude scores were 31.1 ± 5.6 (range 8–40), and practice scores were 35.1 ± 4.4 (range 8–40). Positive attitudes (OR = 1.235, 95% CI: 1.162–1.311, P < 0.001) and aged 41–50 years were independently associated with higher practice scores. Those with the better practice were more likely to be older (OR = 2.603, 95% CI: 1.242–5.452, P = 0.011), nurses (OR = 2.274, 95% CI: 1.210–4.272, P = 0.011) and with junior/intermediary/vice-senior title (OR = 2.326, 95% CI: 1.030–5.255, P = 0.042; OR = 2.847, 95% CI: 1.226–6.606, P = 0.015; OR = 4.547, 95% CI: 1.806–11.452, P = 0.001, respectively). Subgroup analysis revealed significant differences in knowledge between technicians and physicians and nurses and between staff working in tertiary hospitals and non-tertiary hospitals. Knowledge is positively correlated with attitude (β = 0.54, P < 0.001), and attitude is positively correlated with practice (β = 0.37, P < 0.001). Attitudes significantly mediated the association between knowledge and practice (β = 0.119, P < 0.001).

Conclusion

The radiology medical workers showed moderate knowledge but good attitudes and practices of prevention and diagnosis of COVID-19. Attitudes were found to be positively associated with better practices of prevention and diagnosis of COVID-19. Attitudes significantly mediated the association between knowledge and practice.
The risk of injuries during work and its association with precipitation: New insight from a sentinel-based surveillance and a case-crossover design
Authors: Tian Tian , Lin Xiao , Huang Tingyuan , Zhang Kai , Shi Congxing , Wang Pengyu , Chen Shimin , Guo Tong , Li Zhiqiang , Qin Pengzhe , Liang Boheng , Zhang Wangjian , Hao Yuantao
Published: March 2023

Background

Injuries during work are often exogenous and can be easily influenced by environmental factors, especially weather conditions. Precipitation, a crucial weather factor, has been linked to unintentional injuries, yet evidence of its effect on work-related injuries is limited. Therefore, we aimed to clarify the impact of precipitation on injuries during work as well as its variation across numerous vulnerability features.

Methods

Records on the work-related injury during 2016–2020 were obtained from four sentinel hospitals in Guangzhou, China, and were matched with the daily weather data during the same period. We applied a time-stratified case-crossover design followed by a conditional logistic regression to evaluate the association between precipitation and work-related injuries. Covariates included wind speed, sunlight, temperature, SO2, NO2, and PM2.5. Results were also stratified by multiple factors to identify the most vulnerable subgroups.

Results

Daily precipitation was a positive predictor of work-related injuries, with each 10 mm increase in precipitation being associated with an increase of 1.57% in the rate of injuries on the same day and 1.47–1.14% increase of injuries on subsequent 3 days. The results revealed that precipitation had a higher effect on work-related injuries in winter (4.92%; 95%CI: 1.77–8.17%). The elderly (2.07%; 95%CI: 0.64–3.51%), male (1.81%; 95%CI: 0.96–2.66%) workers or those with lower educational levels (2.58%; 95%CI: 1.59–3.54%) were more likely to suffer from injuries on rainy days. There was a higher risk for work-related injuries caused by falls (2.63%; 95%CI: 0.78–4.52%) or the use of glass products (1.75%; 95%CI: 0.49–3.02%) on rainy days.

Conclusions

Precipitation was a prominent risk factor for work-related injury, and its adverse effect might endure for 3 days. Certain sub-groups of workers were more vulnerable to injuries in the rain.
Mental health of public safety personnel: Developing a model of operational, organizational, and personal factors in public safety organizations
Authors: Edgelow Megan , Fecica Agnieszka , Kohlen Caroline , Tandal Kirandeep
Published: March 2023

The work of public safety personnel (PSP) such as police officers, firefighters, correctional officers, and paramedics, as well as other PSP, makes them vulnerable to psychological injuries, which can have profound impacts on their families and the communities they serve. A multitude of complex operational, organizational, and personal factors contribute to the mental health of PSP; however, to date the approach of the research community has been largely to explore the impacts of these factors separately or within single PSP professions. To date, PSP employers have predominantly focused on addressing the personal aspects of PSP mental health through resiliency and stress management interventions. However, the increasing number of psychological injuries among PSPs and the compounding stressors of the COVID-19 pandemic demonstrate a need for a new approach to the study of PSP mental health. The following paper discusses the importance of adopting a broader conceptual approach to the study of PSP mental health and proposes a novel model that highlights the need to consider the combined impacts of operational, organizational, and personal factors on PSP mental health. The TRi-Operational-Organizational-Personal Factor Model (TROOP) depicts these key factors as three large pieces of a larger puzzle that is PSP mental health. The TROOP gives working language for public safety organizations, leaders, and researchers to broadly consider the mental health impacts of public safety work.
A qualitative study on health stigma and discrimination in the first year of the COVID-19 pandemic: Lessons learnt from a public health perspective
Authors: Yu Chou Chuen , Tang Bernard , Low James Alvin , Mathew Mathews , Straus Sharon , Fahim Christine
Published: March 2023

Background

Stigmatisation, misinformation and discrimination have been magnified globally due to the COVID-19 pandemic. The healthcare sector was not spared from this. We conducted a transnational study, using the Health Stigma and Discrimination framework (HSDF) to explore public perception and reactions to the COVID-19 pandemic in a multicultural context. Findings from the Asian arm of the study, sited in Singapore, are reported in this paper.

Methods

This phenomenological research deployed semi-structured informant interviews using non-probability sampling approaches to recruit members of the public. Interviews were coded independently by two researchers and thematic analysis was used to analyse the responses.

Results

Twenty-nine members of the public (23–80 years old) were interviewed between Oct 2020 to Feb 2021. Five major themes were identified: (i) perception of stigma amongst respondents, (ii) experiences of stigma amongst respondents, (iii) views on what drove stigma and misinformation, (iv) facilitators in preventing and reducing stigma and misinformation, and (v) ageist attitudes towards older adults. Overall, construction workers living in dormitories, healthcare workers, and to some extent tourists from China, were perceived to have been stigmatised and shunned by the public. Place-based stigmatisation was common; participants responded by avoiding places that had confirmed cases of COVID-19. Perceived stigma was temporary and not enduring, driven at the outset by fear of being infected. This study also identified the role played by trust in reducing stigmatisation. The relative absence of politicising of issues and high-quality information readily disseminated to the public were reported as factors that could have reduced and prevented stigma and misinformation on the various groups. Ageist attitudes were observed in some participants with older adults being labelled as vulnerable, susceptible to misinformation and being less able to cope during the pandemic.

Conclusion

Through the lens of the HSDF, this study provided an exploratory account of the nature of stigma that resulted from the COVID-19 pandemic in an Asian context. It also shed light on facilitators in preventing and reducing stigma during an outbreak especially the role of trust and communications during a public health crisis.
On the determinants and the role of the payers in the uptake of genetic testing and data sharing in personalized health
Authors: Kalouguina Veronika , Wagner Joël
Published: March 2023

Background

New health technologies and data offer tailored prevention and spot-on treatments, which can considerably reduce healthcare costs. In healthy individuals, insurers can participate in the creation of health capital through data and preventing the occurrence of a disease. In the onset of a disease, sequencing an individual's genome can provide information leading to the use of more efficient treatments. Both improvements are at the core of the “personalized health” paradigm. As a positive side effect, a reduction in healthcare costs is expected. However, the integration of personalized health in insurance schemes starts with a closer understanding of the demand drivers.

Methods

Using novel data from a survey carried out in Switzerland, we determine the factors influencing the uptake and sharing of data from genetic tests. In our regression analyses, we use five sets of socioeconomic, lifestyle, health insurance, sentiment, and political beliefs variables. Furthermore, two framings assess the willingness to undertake a test and the readiness to share results with an insurer when the costs of the test are borne by the insurer or the individual.

Results

We find that socioeconomic, lifestyle, or political belief variables have very little influence on the uptake of tests and the sharing of data. On the contrary, our results indicate that sentiment and insurance factors play a strong role. More precisely, if genetic tests are perceived as a mean to perform health prevention, this pushes individuals to take them. Furthermore, using the insurer's smartphone app leads to an increase of the likelihood to undergo a test and doubles the probability to share related data. Regarding insurance plans and deductible levels, there is no strong correlation neither with the willingness to take a test nor to share the data. Finally, individuals with complementary health insurance plans are less likely to share results. From the framings for the payment of genetic tests, our results indicate a positive effect of the insurer as a payer on the willingness to undertake tests as well as on data sharing.

Conclusion

Our results lay the ground for a deeper understanding of the role of payers on health decisions and sharing of health-related data. In particular, we find that it is relevant for health insurers to engage with their clients.
Mechanisms of SiO oxidation: Implications for dust formation
Authors: Andersson Stefan , Gobrecht David , Valero Rosendo
Published: March 2023

Reactions of SiO molecules have been postulated to initiate efficient formation of silicate dust particles in outflows around dying (AGB) stars. Both OH radicals and H2O molecules can be present in these environments and their reactions with SiO and the smallest SiO cluster, Si2O2, affect the efficiency of eventual dust formation. Rate coefficients of gas-phase oxidation and clustering reactions of SiO, Si2O2 and Si2O3 have been calculated using master equation calculations based on density functional theory calculations. The calculations show that the reactions involving OH are fast. Reactions involving H2O are not efficient routes to oxidation but may under the right conditions lead to hydroxylated species. The reaction of Si2O2 with H2O, which has been suggested as efficient producing Si2O3, is therefore not as efficient as previously thought. If H2O molecules dissociate to form OH radicals, oxidation of SiO and dust formation could be accelerated. Kinetics simulations of oxygen-rich circumstellar environments using our proposed reaction scheme suggest that under typical conditions only small amounts of SiO2 and Si2O2 are formed and that most of the silicon remains as molecular SiO.
Interstate war and food security: Implications from Russia's invasion of Ukraine
Authors: Nguyen Trung T. , Timilsina Raja R. , Sonobe Tetsushi , Rahut Dil B.
Published: March 2023

In this article, we review and shed light on the interlinkages between interstate war and food insecurity and discuss global policy actions needed to address the challenges of food insecurity due to interstate war. We conceptualize the interlinkages between these two issues with a focus on: (i) the most critical and direct cause of interstate war, namely geo (territorial) political conflict, and (ii) the mechanisms through which interstate war affects four different food security pillars, namely food availability, food access, food utilization, and food stability. We position that, if unsuccessfully addressed, geo (territorial) political conflicts will create a vicious cycle of violence and hunger. This position is illustrated by analyzing recent Russia's invasion of Ukraine. Herein a summary of the root and nature of the invasion and how it has affected global food security is presented, with a discussion on the potential considerations and solutions to avoid the cycle of violence and hunger.
Application of riparian buffer zone in agricultural non-point source pollution control—A review
Authors: Wu Shaoteng , Bashir Muhammad Amjad , Raza Qurat-Ul-Ain , Rehim Abdur , Geng Yucong , Cao Lei
Published: March 2023

Water is an important natural element of our environment, and its management and security are also serious concerns. Agricultural non-point source pollution (NPSP) is one of the major sources of contaminants causing water quality degradation. A riparian buffer zone is a vegetative cover adjacent to water channels that positively contributes to pollutant filtration and sediment trapping. It has the potential to filter nutrients, reduce nutrients and pesticide leakage, provide habitat and protection against floods, minimize erosion issues, improve biodiversity and ecological connectivity, and add aesthetics to the area. Moreover, it is inexpensive and requires little maintenance making buffer zone an attractive approach to NPSP control. In this review, we have enlightened the effects of the riparian buffer zone on water quality and agricultural NPSP and how its structures and mechanisms contribute to controlling water pollution effectively. We conclude that the riparian buffer zone is an effective technique for water safety, NPSP control, and creating a suitable environment for terrestrial and aquatic species. Moreover, it has the potential to reduce the water temperature due to the shading effect and sustain water habitat acting as a climate adaptation tools. Buffer zones should be adopted for agricultural non-point source pollution and achieve environmental sustainability. However, the long-term influence of the riparian buffer zone on trapping NPS pollutants, soil properties, and groundwater quality is s research gap.
Internal audits as a tool to assess the compliance with biosecurity rules in a veterinary faculty
Authors: Humblet Marie-France , Saegerman Claude
Published: March 2023

Introduction

The present paper proposes a tool to follow up the compliance of staff and students with biosecurity rules, as enforced in a veterinary faculty, i.e., animal clinics, teaching laboratories, dissection rooms, and educational pig herd and farm.

Methods

Starting from a generic list of items gathered into several categories (personal dress and equipment, animal-related items, infrastructures, waste management, management of material/equipment and behavior), a checklist was created for each sector/activity mentioned above, based on the rules and procedures compiled in the Faculty biosecurity standard operating procedures. Checklists were created as Excel™ files. For each sector, several sheets were elaborated, i.e., one per specific activity: for example, the following sheets were created for the equine clinic: class 1-2 hospitalization (class 1 = non-infectious conditions; class 2 = infectious disease with a low or non-existent risk of transmission), class 3 hospitalization (class 3 = infectious disease with a moderate risk of transmission; these patients are suspected of having an infectious disease and being contagious for other patients and/or for humans) and consultation.

Results

Class 4 area, which corresponds to the isolation unit and aims at housing patients suffering from infectious diseases with a significant risk of transmission (including notifiable conditions), was not audited at that period, as it was undergoing renovation works. The audit relied on observations performed by a unique observer to ensure standardization. Observed items were presented as yes/no and multiple-choice questions. A scale from 0 to 3 or 4 (depending on the item) allowed scoring each item, i.e., 0 corresponding to 100% compliance with the procedure and the highest score to the worst situation. A median and average global score was also estimated by category and by activity.

Discussion

The methodology described in the present paper allows estimating the compliance with biosecurity standard operating procedures in a specific sector and/or for a given activity. The identification of criteria needing improvement is a key point: it helps prioritizing actions to be implemented and awareness raising among people concerned. Regular internal auditing is an essential part of a biosecurity plan, the frequency being conditioned by the risk linked to a specific activity or area (i.e., more frequent audits in risky situations).
Oil Cakes of Essential Oil Plants as a Source of Prebiotics for Poultry Production
Authors: Mazanko Maria , Prazdnova Evgeniya , Statsenko Varvara , Bren Anzhelica , Rudoy Dmitry , Maltseva Tatiana , Chistyakov Vladimir , Chikindas Michael
Published: March 2023

The oil cakes of essential oil plants were screened for prebiotic properties for further development of prebiotic feeds for livestock animals based on these essential oil plants’ extracts. For screening, a microbiota model of the chicken cecum, which was created on the basis of an artificial intestinal medium, was used. This model renders it possible to simulate conditions close to intestinal ones. Oligofructose, inulin, β-glucan, psyllium seeds, and apple fiber at a concentration of 0.5% were used as substances with known prebiotic properties. The oil cake concentration was 0.5%, 1%, 2%, and 4%. The direct antimicrobial effect of the cakes on intestinal bacteria was also investigated. The ability of the cakes to stimulate a decrease in the pH level by Lactobacillus was studied under conditions close to intestinal ones. It was shown that the cakes of big seed false flax (Camelina sativa), brown mustard (Brassica juncea), and spicate lavender (Lavandula angustifolia) exhibit prebiotic properties in relation to the microbiome of chickens in model experiments. They enhance the acid-forming properties of lactic acid bacteria, thereby lowering the pH of the medium. This leads to a decrease in the number of Enterococcus, Escherichia coli, and lactose-positive bacteria, as well as a complete suppression of Proteus. The optimal oil cake concentrations are 1% and 2%. These oil cakes are promising sources of prebiotics for the development of prebiotic feed for agriculture.
The Role of Smallholder Farming on Rural Household Dietary Diversity
Authors: Hlatshwayo Simphiwe Innocentia , Slotow Rob , Ngidi Mjabuliseni Simon Cloapas
Published: March 2023

The importance of smallholder farming is increasingly recognized in rural areas where increased crop productivity and market participation can effectively improve their dietary diversity and nutrition quality. However, rural households are still faced with severe food insecurity and malnutrition. The study sought to assess the role of smallholder farming in crop productivity and market access on rural household dietary diversity. The secondary data were collected using a quantitative research method, and 1520 participants were selected using a stratified random sampling technique. The descriptive results showed that cereals were the most (98%) consumed food group, while vegetables and fruits were the least consumed food groups, at 37% and 23%, respectively. The results from the Household Dietary Diversity Score (HDDS) showed that 57% of smallholder farmers consumed highly diverse diets (more or equal to six food groups), whereas 25% and 18% of smallholder farmers consumed medium dietary diversity (four to five food groups) and low diverse diets (less or equal to three food groups), respectively. The findings from the Conditional Mixed Process (CMP) and Poisson endogenous treatment effect models showed that household size, ownership of livestock, wealth index, and involvement in crop production positively influenced household dietary diversity. On the other hand, output and access to market information showed a negative effect. Social grants had contradicting effects: they had a negative impact on the HDDS received from crop productivity while they had a positive effect on the HDDS from market participation. Providing different ways smallholder farmers can use their funds effectively can help improve household dietary diversity and nutrition quality. The study recommended that more workshops and training be conducted that cover all the sustainable production systems that smallholder farmers can undertake to produce different food groups. These will raise awareness among smallholder farmers about the requirements for balanced diets for food and nutrition security.