bluuebunny/crossref_metadata_2025 huggingface dataset:
Meta–Analysis of Corporate Reputation and Intellectual Capital Formation
Authors:   Department Social Work, Universidad Nacional Autónoma de México, Mexico. Email: javierg@unam.mx, Carreon Guillen Javier ,   ORCID: https://orcid.org/0000–0002–8915–0958., García Lirios Cruz ,   Department Social Work, Universidad Autónoma del Estado de México, Mexico. Email: cgarcial@uaemex.mx; ORCID: https://orcid.org/0000–0002–9364–6796., Yaneth Quiroz Campas Celia ,   Department Administrative Sciences, Instituto Tecnológico de Sonora, Mexico. Email: celia.quiroz@itson.edu.mx; ORCID: https://orcid.org/0000–0002–6068–1552., Alexander Vallejo Montoya Elías ,   Department Administrative Sciences, Universidad Católica Luis Amigo, Colombia. Email: elias.vallejomo@amigo.edu.co; https://orcid.org/0000–0002–8832–4098., Espinoza Morales Francisco ,   Department Administrative Sciences, Universidad de Sonora. Mexico. Email: fespinoz@navojoa.uson.mx; ORCID: https://orcid.org/0000–0002–4552–5893., Hugo Meriño Córdoba Victor ,   Department Administrative Sciences, Universidad Católica Luis Amigo, Mexico. Email: victor.merinoco@amigo.edu.mx; ORCID: https://orcid.org/0000–0001–8911– 7202., Ysabel Martínez de Meriño Carmen ,   Department Administrative Sciences, Universidad Católica Luis Amigo, Mexico. carmen.martidezde@amigo.edu.mx; ORCID: https://orcid.org/0000–0002–8134–2306., Vicente Ovalles Toledo Luiz ,   Department Administrative Sciences, Universidad Autónoma de Sinaloa, Mexico. Email: luiz.ovalles@uas.edu.mx; ORCID: https://orcid.org/0000–0003–0289–3394., Judith Brito Carrillo Clara ,   Department Administrative Science, Universidad de la Guajira, Colombia. Email: clarabrito@uniguajira.edu.co; ORCID: https://orcid.org/0000–0001–8788–7326.
Published: December 2022

The meta–analyses reveal the factors that during a period have influenced the behavior of a formal sector such as Higher Education Institutions
SARS–CoV–2 Reinfections as Compared with Primary Infections in Vaccinated People. Are there Clinical–Epidemiological Differences of Importance for Health Interventions between First Infection and Reinfection in Vaccinated People?
Authors:   Specialist in Family and Community Medicine, Health Center Santa Maria de Benquerencia. Regional Health Service of Castilla la Mancha (SESCAM), Toledo, Spain., Luis Turabian Jose
Published: December 2022

Background Although reinfections in vaccinated individuals should theoretically be lighter than primary infections in vaccinated individuals, the clinical–epidemiological differences and their importance regarding public health between cases of COVID–19 reinfection with vaccination and cases of COVID–19 primary infection with vaccination are not known.
Knob, Clot, Protuberance–Nodular Fasciitis
Authors:   Consultant Histopathologist, A.B. Diagnostics, A–1, Ring Road, Rajouri Garden, New Delhi 110027, India., Bajaj Anubha
Published: December 2022

Nodular fasciitis emerges as a benign, self limited, mesenchymal neoplasm of fibroblastic or myofibroblastic derivation.
Biliary Atresia-Challenges of Liver Transplantation
Authors:   Public Health Consultant Bengaluru & Visiting Professor of Practice, School of Environment Sciences, Public Health, and Sanitation Management, Karnataka State Rural Development and Panchayat Raj University (KSRDPRU), GADAG, 582101 Karnataka, India., Krishnarao Suresh
Published: December 2022

Objective: Biliary Atresia is a rare condition in early infancy in India, as nearly 2500-5000 such children are born each year. Liver transplantation is a highly successful treatment for biliary atresia, as survival after surgery has increased dramatically in recent years
Penerapan Zachman Framework dalam Merancang Customer Relationship Management pada Bank Central Asia Indonesia
Authors: Budiraharjo R. , Nugraha Boyke Agung
Published: December 2022

Implementasi arsitektur Zachman Framework dalam penyusunan Customer Relationship Management (CRM) dimaksudkan untuk memetakan komposisi organisasi secara keseluruhan dan menggambarkannya sebagai sistem informasi perusahaan yang saling bertautan. Dalam penelitian ini, Zachman Framework digunakan untuk membangun perancangan arsitektur Customer Relationship Management di bank BCA. Tabel Zachman Framework yang digunakan memiliki 3 baris dan 5 kolom, Pada setiap kolom merincikan data, proses, dan jaringan yang mendefinisikan hal-hal yang berkaitan dengan perusahaan, tentang informasi apa yang akan ditangani sedangkan pada baris merincikan Deskripsi Ruang Lingkup, Model Bisnis, Model Sistem Informasi, Model Teknologi, dan Deskripsi Terperinci. Hasil yang didapatkan saat merancang CRM adalah perancangan desain sistem, yang dipetakan dengan diagram UML dan perancangan aplikasi CRM berbasis situs web yang memiliki fungsi mengelola data nasabah, menampilkan produk perbankan, membuat forum CSO dengan nasabah, dan menampilan Pertanyaan yang Sering Diajukan (FAQ) untuk meningkatkan layanan terhadap nasabah bank.
Klasifikasi Penentuan skema Uji Sertifikasi di LSP UDINUS bagi mahasiswa Progrdi Sistem Informasi UDINUS dengan Algoritma Decision Tree (C4.5)
Authors: Winarno Agus , Warsito Budi , Wibowo Adi , Zeniarja Junta
Published: December 2022

AbstrakPenerapan Algoritma Decision Tree (C4.5) dan Eksperimen proses klasifikasi dilakukan menggunakan data nilai mahasiswa program studi S1 Universitas Dian Nuswantoro dengan 120.232 dataset menggunakan metode klasifikasi dengan Algoritma Decision Tree menghasilkan 99,99 % dan menghasilkan 7 klasifikasi  dengan rekomendasi ntuk pelatihan dan uji sertifikasi di Lembaga sertifikasi profesi UDINUS pada  5 klasifikasi yaitu klasifikasi  pred C sejumlah 2.355 data, pred BC sejumlah 4.633, pred B sejumlah 38.420 , pred AB sejumlah  33.414  dan pred A  sejumlah 37.230 dan 2  klasifikasi  yang tidak direkomendasikan yaitu klasifikasi pred D 1.440 dan pred E sejumlah 2.784 yang memberikan penyesuaian kurikulum pendidikan di Universitas Dian Nuswantoro dengan lembaga Sertifikasi dan Kebutuhan pekerjan. Kata Kunci: Sertifikasi, klasifikasi, mahasiswa, Tree Algorithm, rekomendasi
Sistem Informasi Manajemen Inventory Barang Gudang Berbasis Website Pada Bariklie Collection
Authors: Oktafiani Santi , Matondang Nur Hafifah , Wirawan Rio
Published: December 2022

Semakin berkembangnya teknologi informasi menjadikan beberapa sektor baik itu pendidikan hingga perekonomian memanfaatkan penggunaan sistem informasi untuk meningkatkan kinerja serta efektifitas proses bisnis yang terdapat di dalamnya. Salah satu contoh pemanfaatan sistem informasi pada sektor perekonomian adalah manajemen pengelolaan pada inventory barang yang dapat mempercepat proses perhitungan barang dan pencarian data barang. Seperti yang diketahui bahwa masih terdapat usaha dagang yang belum menerapkan sistem informasi di dalam proses bisnisnya. Bariklie Collection merupakan usaha dagang yang bergerak dibidang penjualan celana anak dengan sistem penjualan grosir kepada reseller. Penerapan sistem informasi terkait proses bisnis Bariklie Collection belum dilakukan dengan baik sehingga masih menggunakan cara manual di dalam pengolahan inventory barang yang mengakibatkan terjadinya kesalahan pencatatan stok barang, tidak akuratnya data stok dan pegawai sering lambat terhadap proses pengadaan barang jika stoknya habis. Maka dari itu, diperlukan suatu sistem informasi yang dapat mengatur persediaan barang, membuat pesanan produksi, mengontrol barang keluar, dan melaporkan data. Sebagai landasannya, penelitian ini memanfaatkan proses pengembangan sistem Prototype, basis data MySQL dan pemrograman PHP. Analisis ini menghasilkan pembuatan sistem inventory yang dapat membantu mempercepat pegawai dalam pendataan stok barang, menjadikan data yang dihasilkan akurat dan mempermudah proses pelaporan data kepada pemilik Bariklie Collection.
The Influence of Social Media Users on Purchasing Decisions on UKM in Pontianak
Authors: Alfikri Rahmat , Wardana Dwiyadi Surya
Published: December 2022

There are 57% of the 100 instragram social media users who are used as respondents, with the method of retrieving Accidental Simple Random Sampling, the data obtained is processed using Structural Equation Modeling (SEM) through the IBM Amos v26 program. The purpose of this study is to analyze the extent to which social media users influence purchase decisions. Findings. It is derived from the marketing dimension that Online Communities, Interaction, and Sharing of Content have no positive effect on Social Media, but Accessibility and Credibility have a positive effect on Social Media. Social Media has an influence on Purchasing Decisions, and social media cannot be said to be an intervening variable that affects the relationship between independent variables and dependent variables into indirect and un observable and measurable relationships.
Performance Measurement of Human Resources PT. Pulau Bintan Jaya Based on the Human Resource Scorecard Model
Authors: Mardiyah Mardiyah , Lumbanraja Prihatin , Madya Faizal
Published: December 2022

PT Pulau Bintan Jaya is one of the foreign investment companies producing crumb rubber in Riau Islands Province. The company had been in operation since 1969, producing rubber with a few measures which were Standard Indonesian Rubber (SIR) 5, SIR 10, and SIR 20 per customer request. Companies have conducted employee performance measurements but have not specifically measured employee performance by linking it to company strategic functions. Current performance assessments are not yet focused on human resource development efforts. There were still poorly educated employees who served as team leaders and as supervisors. As a result, work-related communication became difficult and led to multiple obstacles under which employment resources became inadequate, and the targets of corporate performance unattainable. There are issues relating to the quality of human resources, and companies have been declining demand and declining production rates for several months. The decline in demand from customers has become one of the issues to evaluate in the company's performance measurement, due to its inadequate strategic resource management. It requires alightnment of the work systems to capture the role of human resources, while in this regard some current case work accident are still faund annually in the production section, even though for the past three consecutive years the accident rate has declined, it needs to be figured out by performing performance measurements. A human resource scorecard measures the performance of human resources by finding solutions to the weaknesses of human managerial resources in PT. Pulau Bintan Jaya, and assist in linking mission vision and strategic objectives. In this study, the design results were obtained as follows: there are 15 strategic goals and 32 Key Performance Indicators, special elements of the human resource system can be driven by 16 performance drivers (called Lagging Indicators), and 16 performance outputs to be achieved (called Leading Indicators), while the results Measurement of employee performance in PT Pulau Bintan Jaya using the Human Resource Scorecard method obtained good results.
The Influence of Service Quality and Delivery Prices on Customer Satisfaction in Bandar Jaya
Authors: Faulina Ida , Utami Putri Lisa , F Sanjaya Vicky
Published: December 2022

One of the factors that underlie the success and development of shipping service companies is the quality of service and also the shipping rates set by the company. These two factors have a major impact on customer interest and satisfaction in using the delivery service. This study aims to determine whether the quality of service and freight rates affect customer satisfaction. And from the research conducted, it can be concluded that the quality of service and freight rates affect customer satisfaction. This study uses a sample of 50 customers, the data processing method uses the Smart Pls 3 application.
The Influence of Work Shifts and Work Stress on Employee Performance at the Alfamart Kotabumi Branch, North Lampung
Authors: Santika Wulan , Fitrianita Siska , F Sanjaya Vicky
Published: December 2022

The results of the interview above show that the work shift factor gets the highest position, which is as many as 13 answers. Then, the second position is work stress as many as 8 answers and it is concluded that the factors that have a major influence on employee performance are work shifts and work stress. To strengthen indications of declining employee performance, the authors conducted interviews with 15 employees. These interviews were conducted with employees and the results could be more objective. Interviews were conducted to determine the factors that influence the decline in employee performance. Of the 15 employees, each answered 2 answers regarding the factors that decreased employee performance.
SOBRE UM MATERIAL CURRICULAR EDUCATIVO INTEGRADOR E SUA RELAÇÃO COM OS CONHECIMENTOS DE PROFESSORES DE EDUCAÇÃO FÍSICA E MATEMÁTICA
Authors: Suely Souto Lívia , Lima Kátia , Patrícia Nogueira de Castro e Almeida Shirley
Published: December 2022

As relações que os professores têm com os materiais curriculares educativos e os conhecimentos docentes nos direcionaram neste estudo cujo objetivo é discutir os conhecimentos mobilizados por professores de Educação Física e Matemática dos Anos Iniciais do Ensino Fundamental ao interagirem com um material curricular educativo integrador. Para tanto, utilizamos as ideias de integração curricular, visando uma conexão entre as duas disciplinas, numa perspectiva metodológica que se enquadra dentro da pesquisa qualitativa. A coleta de dados ocorreu por meio de entrevistas guiadas por um roteiro semiestruturado, realizadas em campo com um professor de Educação Física e duas professoras que ensinam Matemática nos Anos Iniciais, após analisarem um material curricular educativo integrador. Os resultados apontam que os conhecimentos que esses professores mobilizaram podem contribuir para o seu desenvolvimento profissional, ensejando novos estudos e reflexões sobre o conhecimento docente e sua relação com os materiais curriculares diante de outras possibilidades de organização do currículo escolar.
RESOLUÇÃO DE PROBLEMAS E ÁREA DE TRIÂNGULO: ANÁLISE DOS CONHECIMENTOS DE ALUNOS DO 6º ANO DO ENSINO FUNDAMENTAL
Authors: Aparecida Rozario Tereza , Carlos de Proença Marcelo
Published: December 2022

O objetivo deste artigo foi identificar e analisar os conhecimentos de alunos do 6.º ano do Ensino Fundamental durante a resolução de um problema, envolvendo área de triângulo, com base nas enunciações produzidas por eles. Participaram da pesquisa 33 alunos de uma escola pública situada em um município do Estado do Paraná. A pesquisa foi desenvolvida em meio ao ensino híbrido decorrente das medidas sanitárias, em virtude da pandemia de COVID-19. Foram utilizados como instrumentos de coleta dedados: gravação das aulas no Google Meet, no netbook, registros no caderno, na folha xerocopiada e via WhatsApp. Para a análise dos dados coletados, foi realizada a leitura das falas e dos registros feitos pelos alunos, a partir de uma situação de matemática, a qual foi desenvolvida seguindo as cinco ações de Proença (2018) e as noções de Lins (2012). A partir da análise dos dados, foi possível perceber a importância de dar voz aos alunos para entender o que pensam/fazem quando estão diante de uma situação de matemática, de modo que, ao longo das cinco ações, os grupos A, B, C, D e F enunciaram que: um metro representa 100 centímetros; o valor a ser pago por cada metro de grama é R$ 70,00; encontrar a área de triângulo, que é o gramado, equivale à metade da área do retângulo; e que se trata de cobrir o gramado (é o que está dentro) e não da soma dos lados do triângulo ou do retângulo.
COVID-19 E PLATAFORMAS DE STREAMING: INTERVENÇÕES NO PROGRAMA RESIDÊNCIA PEDAGÓGICA À LUZ DA EDUCAÇÃO MATEMÁTICA CRÍTICA
Authors: Geter de Melo Pereira Arthur , Pasolini Milli Elcio , Auxiliadora Vilela Paiva Maria
Published: December 2022

Este texto tem por objetivo relatar o planejamento, o desenvolvimento e os resultados obtidos em intervenções sobre tratamento da informação e Covid-19 realizadas no Ensino Médio. Foram ações conduzidas por residentes do Programa Residência Pedagógica, sob supervisão do professor preceptor, em encontros remotos síncronos junto a um questionário disponibilizado aos estudantes via Google Forms. Teve como proposta discutir as transformações sociais causadas pela pandemia da Covid-19 explorando a utilização das plataformas de streaming ao analisar gráficos e reportagens por meio da Educação Matemática Crítica proposta por Ole Skovsmose. Os resultados mostraram que os estudantes se engajaram nas discussões coletivas e refletiram sobre temas socialmente relevantes, no papel de leitores e escritores do mundo por meio da matemática. Essa experiência ampliou os horizontes dos futuros educadores matemáticos, constatando que as práticas pedagógicas em aulas de matemática também podem ser palco de discussões e reflexões sobre situações para além da matemática escolar.
Women’s thirty-year contribution to cheetah conservation: An insight into volunteer-based conservation program supported by female scientists
Authors: Marker Laurie , Pfeiffer Lauren , Maketo Tracy , Pöntinen Annetjie
Published: December 2022

Women make up a small percentage of the scientific community, including conservation. Today, conservation efforts are vital for the survival of many species, however there is a gender bias within the conservation field. Encouraging more women into conservation could be a key to increasing efficiency and success in conservation goals of organizations and governments. Here we investigate the long running Earthwatch, working guest and intern volunteer programs of the Cheetah Conservation Fund (CCF) to understand women’s involvement with volunteer based conservation, and questionnaire data to understand women’s contribution to conservation after volunteering and what challenges women face in conservation. Our results showed there was significantly more female volunteers than male volunteers (p-value <0.000) and on average, females contributed to 73.7% of the volunteer population annually. Volunteer’s age at time of volunteering varied between the three volunteer programs. Women’s motivations for volunteering and challenges that women face in conservation was dependent on the volunteers’ age. CCF’s holistic approach to conservation, volunteers’ love for cheetahs and ability to gain practical skills were the leading motivations why women volunteered with CCF. Many (87%) of the female interns said volunteering was a means of helping them gain employment. Women’s credibility, family responsibility and personal safety were the main challenges that women face working in conservation today. Addressing gender disparities in every stage of career progression will lead to overall improved conservation outcomes.
Association of aortic arch and aortic valve calcifications with cardiovascular risk in patients on maintenance hemodialysis
Authors: Liao Min-Tser , Chao Chia-Ter , Wu Chung-Kuan
Published: December 2022

Introduction

This study aimed to investigate the association of aortic arch calcification (AoAC) and aortic valve calcification (AVC) with major adverse cardiovascular events (MACE) and cardiovascular and all-cause mortality in patients on maintenance hemodialysis (MHD).

Methods

This study enrolled 297 adult patients with end-stage kidney disease who were on MHD. They were divided into those with an AoAC score <2 without AVC (n = 70, 23.6%), those with an AoAC score <2 with AVC (n = 96, 32.3%), and those with an AoAC score ≥2 regardless of AVC status (n = 131, 44.1%). We analyzed the risks of MACE, cardiovascular and overall mortality among the three groups using Cox proportional hazard analyses. Survival probabilities were estimated using the log-rank test via the Kaplan–Meier method.

Results

Kaplan–Meier analysis revealed that the MACE-free rate and the survival rates of cardiovascular and overall mortality were significantly higher in adult chronic hemodialysis patients with AoAC score <2 without AVC, followed by those with AoAC score <2 with AVC, and then those with AoAC score ≥2 (log-rank test; all p < 0.01). The grade of AoAC is a significant risk factor for MACE, cardiovascular mortality, and overall mortality after adjusting for age and gender Relative to AoAC score <2 without AVC, adult chronic hemodialysis patients with AoAC score ≥2 remained an independently significantly risk factor of MACE (adjusted hazard ratio, 2.17; 95% confidence interval 1.11–4.20; p = 0.023) after adjusting for age, sex, and all significant variables in baseline characteristics.

Conclusion

AoAC grade was positively correlated with a higher risk of MACE and cardiovascular and overall mortality. Furthermore, the presence of AVC modified the adverse cardiovascular risk associated with AoAC in patients on MHD.
Incidence, management, and prognosis of post-ischaemic ventricular septal defect: Insights from a 12-year tertiary centre experience
Authors: Treille de Grandsaigne Henri , Bouisset Frédéric , Porterie Jean , Biendel Caroline , Marcheix Bertrand , Lairez Olivier , Labaste François , Elbaz Meyer , Galinier Michel , Delmas Clément
Published: December 2022

Background

Among mechanical complications of acute myocardial infarction, ventricular septal defect (VSD) is uncommon but still serious. The evolution of emergency coronary revascularisation paradoxically decreased our knowledge of this disease, making it even rarer.

Aim

To describe ischaemic VSD incidence, management, and associated in-hospital and 1-year outcomes over a 12-years period.

Methods

A retrospective single-centre register of patients managed for ischaemic VSD between January 2009 and December 2020.

Results

Ninety-seven patients were included representing 8 patients/ years and an incidence of 0.44% of ACS managed. The majority of the patients were 73-years-old males (n = 54, 56%) with STEMI presentation (n = 75, 79%) and already presented with Q necrosis on ECG (n = 70, 74%). Forty-nine (51%) patients underwent PCI, 60 (62%) inotrope/vasopressors infusion, and 70 (72%) acute mechanical circulatory support (IABP 62%, ECMO 13%, and Impella® 3%). VSD surgical repair was performed for 44 patients (45%) and 1 patient was transplanted. In-hospital mortality was 71%, and 86% at 1 year, without significant improvement over the decade. Surgery appears to be a protective factor [0.51 (0.28–0.94) p = 0.003], whereas age [1.06 (1.03–1.09), p < 0.001] and lactate [1.16 (1.09–1.23), p < 0.001] were linked to higher 1-year mortality. None of the patients that were managed medically survived 1 year.

Conclusion

Post-ischaemic VSD is a rare but serious complication still associated with high mortality. Corrective surgery is associated with better survival, however, timing, patient selection, and a place for mechanical circulatory support need to be defined.
The combined use of photobiomodulation therapy and platelet-rich fibrin for the management of two MRONJ stage II cases: An alternative approach
Authors: Valamvanos Konstantinos , Valamvanos Theodoros-Filippos , Toumazou Spyridon , Gartzouni Eleni
Published: December 2022

Medication-related osteonecrosis of the jaws (MRONJ) is a relatively rare but serious adverse drug reaction in patients under bone-targeting or antiangiogenic medication for malignant or osteometabolic diseases. The pathogenesis of MRONJ is multifactorial with the inhibition of osteoclasts and angiogenesis considered to play a key role in an individually susceptible environment, thus its prevalence is highly differentiated according to each study. Even though MRONJ has been reported since 2003 and the literature is expanding rapidly about possible risk factors, prevention and treatment options, the successful management with no recurrence is still under controversy. The conservative non-surgical (optimal oral hygiene, systemic antibiotic therapy) and surgical procedures (debridement, sequestrectomy or bone resection) are considered the treatment of choice especially at the early stages. Adjuvant therapies have been proposed to further stimulate bone and tissue healing such as teriparatide, bone morphogenic proteins, platelet concentrates, hyperbaric oxygen, ozone therapy, photodynamic therapy and lasers with promising results. The need to develop minimally invasive treatment protocols using novel technologies in particular for those patients with severe medical histories has been highlighted in the literature. The clinical protocol that has been developed in our dental department, which is effectively contributing to MRONJ management and combines Photobiomodulation therapy (PBMT) with platelet-rich fibrin (A-PRF), will be presented in this article.
Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption
Authors: Gatta Elisa , Bambini Francesca , Buoso Caterina , Gava Maria , Maltese Virginia , Anelli Valentina , Delbarba Andrea , Pirola Ilenia , Cappelli Carlo
Published: December 2022

Purpose

To describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 therapy and drugs known to interfere with L-T4 absorption.

Methods

A PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies and reviews written in English and published online up to 31 August 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.

Results

The available data showed that novel levothyroxine formulations circumvent gastric pH impairment due to multiple interfering drugs such as proton pump inhibitors, calcium or iron supplements, sevelamer, aluminum/magnesium hydroxide and sodium alginate.

Conclusion

New formulations can be taken simultaneously with drugs interfering with L-T4 absorption, in particular liquid formulations. Softgel capsules need more studies to support these data.
Localized urban canopy model and improved anthropogenic heat parameters in the weather research and forecasting model: Simulation of a warm-sector heavy rainfall event over the pearl river delta urban agglomeration
Authors: Huang Zehao , Yang Yuanjian , Bi Xueyan , Zong Lian , Li Wanju , Huang Ling
Published: December 2022

Warm-sector heavy rainfall in South China is a frequent type of precipitation in summer in the Pearl River Delta region. The complexity of the mechanisms involved in the triggering of convection, especially the effects of urbanization, has greatly increased the uncertainty of numerical simulations of warm-sector heavy rainfall. In this study, five new surface parameters with five new anthropogenic heat (AH) parameters were constructed and coupled with the urban canopy model (UCM) of the Weather Research and Forecasting model, version 4.1, based on the local climate zone system over the Pearl River Delta Urban Agglomeration (PRDUA). Taking a typical warm-sector heavy rainfall process that occurred in the PRDUA on 20 April 2019 as an example, five groups of experiments involving different schemes were compared and analyzed, revealing that the precipitation simulated using the localized UCM with the new AH parameters was the best (closest to observations). The localized UCM successfully simulated the increase in 2 m temperature and sensible heat flux and the resultant thermal forcing in urban areas, which promoted the convergence of low-level southerly winds with water vapor and the lifting of the lower-layer warm and humid water vapor to the upper layers in the urban center, leading to a significant increase of precipitation. The improved AH parameters enhanced the anthropogenic heat and its vertical conduction in urban areas, but contributed only marginally to the convergence of 10 m winds. Compared with observations from wind profile radar, it was found that the localized UCM enhanced the accuracy of the simulated horizontal wind field convergence at upper and lower levels, while the improved AH parameters enhanced the accuracy of the simulated low-level jet intensity and vertical movement, which are important drivers for the spatial variation in warm-sector heavy rainfall over the PRDUA. The current findings will be helpful for improving the model skill in simulating warm-sector heavy rainfall over high-density urban areas, as well as enhancing understanding of the impact mechanism of urbanization on the occurrence and development of warm-sector heavy rainfall.
Increasing objectivity associated with anadromous fish redd identification using a discriminant function analysis
Authors: Sellheim Kirsten , Sweeney Jamie , Merz Joseph
Published: December 2022

Many fish species reproduce by creating nests (redds) in alluvial stream gravels, which can be used to track population trends. However, temporal and spatial overlap across multiple redd-building species can hinder redd species classification. This is further complicated when the corresponding adult is not present. Spawning surveys on the Lower American River (LAR) have been conducted since 2003 to document fall-run Chinook Salmon and California Central Valley (CCV) steelhead spawning. Other fish species on the LAR have overlapping reproduction timing, including Pacific Lamprey. Prior to 2016, a redd observed during field surveys that was not associated with a fish observation was assigned species identity based on seasonal timing and professional judgement. However, this method has potential to misidentify the species that built the redd due to overlap in spawning season and similarity in redd dimensions among LAR fish species. To decrease subjectivity associated with unoccupied redd identification, we used occupied redd data to build a discriminant function analysis (DFA), which predicts redd species identity based on field-measured parameters that vary across species including time of year, redd dimensions, and ambient conditions. We compared model accuracy across 6 years in which additional “fish on” observations were added annually to the discriminant function to test whether adding observational data improved model accuracy. We also applied the discriminant function to historical redd data in which species identification was made based on professional judgement to compare the two approaches. DFA accuracy improved with additional years of data, and in the iteration that included the most observational data it was highly accurate in identifying fall-run Chinook Salmon and CCV steelhead (96% and 97%, respectively). Accuracies for Pacific Lamprey were slightly lower (91%) than salmonids due to the relatively low number of “fish-on” redd observations for Pacific Lamprey. Comparisons between the DFA and historical identification based on professional opinion were generally similar, but with up to 19.6% disagreement in some years. Our study demonstrates that physical and temporal metrics can support more accurate species identification, and field data can be used to support more robust population estimates and inform future habitat restoration decisions.
An improved Carnegie-Ames-Stanford Approach model for estimating ecological carbon sequestration in mountain vegetation
Authors: Huang Xu , He Li , He Zhengwei , Nan Xi , Lyu Pengyi , Ye Haiyan
Published: December 2022

The vegetation in mountainous areas is abundant, and its ecological carbon sequestration ability is of great significance to maintain the sustainable and healthy development of the ecological environment. However, when estimating the carbon sequestration of mountain vegetation, the Carnegie-Ames-Stanford Approach (CASA) model assigns a uniform value to the maximum light energy utilization (εmax = 0.389 gC/MJ), ignoring the influence of vegetation types and topographic factors on εmax, resulting in the low accuracy of the CASA model in estimating the carbon sequestration of mountain vegetation. In this paper, the improved CASA model was combined with Landsat 8 Operational Land Imager (OLI) remote sensing image data to improve the estimation accuracy of carbon sequestration of mountain vegetation. The first was the establishment of a linear link between the terrain characteristics (slope and aspect), vegetation types, and εmax in mountainous locations. The second was the improvement of the CASA model’s calculation method for key parameters. The different distributions of the estimation results from the two techniques in 2015 and 2016 are then compared using Landsat 8 data as the data source, and the impact of the terrain factors in the improved CASA model on the estimation results is confirmed. Finally, the improved CASA model and the CASA model are used to estimate the Net Primary Productivity (NPP) of the study area from 2000 to 2020, and the estimated results of the two models are compared with the computation results of the MODIS data NPP product. The findings indicate that the improved CASA model’s estimation results have a higher degree of fit and a better correlation. The improved CASA model aids in precisely understanding the ecological carbon sequestration potential of mountain areas and increases the estimation accuracy of vegetation carbon sequestration in mountainous areas.
A Wnt-related gene expression signature to improve the prediction of prognosis and tumor microenvironment in gastric cancer
Authors: Kong Shuai , Li Zhi , Wang Yuanyuan , Zhang Zheming , Jia Xianghao , Gao Xinxin , Cong Bicong , Zhang Fangxu , Zhang Jing , Zheng Chunning
Published: December 2022

Background: Most gastric cancer (GC) patients were diagnosed in the advanced stages without obvious symptoms, which resulted in the increased risk of death. Although the combination therapies have showed survival benefit of patients, there is still urgent need to explore the underlying mechanisms of GC development and potential novel targets for clinical applications. Numerous studies have reported the upregulation of Wnt signaling pathway in human GC, which play important role during GC development and progression. However, the current understanding of Wnt signaling pathway is still limited due to its complexity and contradictory effect on different stages of GC tumor microenvironment.

Method: We used The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset to screen Wnt signaling pathway-associated genes by ssGSEA and correlation analysis. Three molecular subtypes were constructed based on a consistent clustering analysis. The key Wnt-related genes were screened through univariate cox analysis, lasso, and stepwise regression. In addition, the Gene Set Enrichment Analysis (GSEA) were performed to explore potential molecular pathways regulated by the Wnt-related gene signatures. ESTIMATE was utilized for evaluating the immune cell populations in GC tumor microenvironment.

Results: Three molecular subtypes associated to Wnt were identified, and 7 key Wnt-related genes were screened to establish a predictive RiskScore model. These three molecular subtypes showed significant prognostic differences and distinct functional signaling pathways. We also found the downregulated immune checkpoint expression in the clust1 with good prognosis. The RiskScore model was successfully validated in GSE26942 dataset. Nomogram based on RiskScore and Gender had better prognostic predictive ability.

Conclusion: In summary, our study showed that the Wnt-related genes could be used to predict prognosis of GC patients. The risk model we established showed high accuracy and survival prediction capability.
Gender-based violence programming in times of COVID-19: Challenges, strategies and recommendations
Authors: Markan Mridu , Dhingra Radhika , Segan Mehak , Dabla Vandana , Sagar Moni , Neogi Sharmila , Dey Shrija , Chakravarty Nayan
Published: December 2022

Gender-Based Violence (GBV) remains the most challenging and threatening manifestation of gender inequality in Indian society. The outbreak of COVID-19 in India increased the risk of exposure to GBV, often compared to the “shadow pandemic". Girls suffered disproportionally compared to boys during the pandemic -from being pulled out of schools, facing movement restrictions, and being more susceptible to forced marriage and household violence. Pre-existing gender inequalities and regressive gender norms, along with economic instability, also contributed to creating a milieu for violence to thrive. Additionally, the pandemic also challenged GBV service provision and program implementation at the community level. To meet the increasing needs of women and girls during the crisis, national and local civil society organizations attempted to adapt GBV programming and promote innovative approaches to tackle GBV. The secondary review provides insight on the GBV impact due to the COVID-19 pandemic and provides an overview of various challenges at the level of individual, community, institution, and policy. The literature review also highlights strategies adopted to combat GBV in private, public and cyberspace.
Age-dependent nasal immune responses in non-hospitalized bronchiolitis children
Authors: Cortegano Isabel , Rodríguez Mercedes , Hernángómez Susana , Arrabal Alejandro , Garcia-Vao Carlos , Rodríguez Javier , Fernández Sandra , Díaz Juncal , de la Rosa Belén , Solís Beatriz , Arribas Cristina , Garrido Felipe , Zaballos Angel , Roa Sergio , López Victoria , Gaspar Maria-Luisa , de Andrés Belén
Published: December 2022

Bronchiolitis in children is associated with significant rates of morbidity and mortality. Many studies have been performed using samples from hospitalized bronchiolitis patients, but little is known about the immunological responses from infants suffering from mild/moderate bronchiolitis that do not require hospitalization. We have studied a collection of nasal lavage fluid (NLF) samples from outpatient bronchiolitis children as a novel strategy to unravel local humoral and cellular responses, which are not fully characterized. The children were age-stratified in three groups, two of them (GI under 2-months, GII between 2-4 months) presenting a first episode of bronchiolitis, and GIII (between 4 months and 2 years) with recurrent respiratory infections. Here we show that elevated levels of pro-inflammatory cytokines (IL1β, IL6, TNFα, IL18, IL23), regulatory cytokines (IL10, IL17A) and IFNγ were found in the three bronchiolitis cohorts. However, little or no change was observed for IL33 and MCP1, at difference to previous results from bronchiolitis hospitalized patients. Furthermore, our results show a tendency to IL1β, IL6, IL18 and TNFα increased levels in children with mild pattern of symptom severity and in those in which non RSV respiratory virus were detected compared to RSV+ samples. By contrast, no such differences were found based on gender distribution. Bronchiolitis NLFs contained more IgM, IgG1, IgG3 IgG4 and IgA than NLF from their age-matched healthy controls. NLF from bronchiolitis children predominantly contained neutrophils, and also low frequency of monocytes and few CD4+ and CD8+ T cells. NLF from infants older than 4-months contained more intermediate monocytes and B cell subsets, including naïve and memory cells. BCR repertoire analysis of NLF samples showed a biased VH1 usage in IgM repertoires, with low levels of somatic hypermutation. Strikingly, algorithmic studies of the mutation profiles, denoted antigenic selection on IgA-NLF repertoires. Our results support the use of NLF samples to analyze immune responses and may have therapeutic implications.
BAFF blockade attenuates acute graft-versus-host disease directly via the dual regulation of T- and B-cell homeostasis
Authors: Jeon Youngwoo , Lim Jung-Yeon , Im Keon-Il , Kim Nayoun , Cho Seok-Goo
Published: December 2022

Introduction

B-cell-activating factor (BAFF) is associated with donor-specific antibodies and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the effects of BAFF on T-cell physiological function have not been fully elucidated in acute GVHD.

Methods

We examined the effects of belimumab, a monoclonal antibody targeting BAFF, for the treatment of acute GVHD. We examined the effects of T cells and B cells separately when inducing GVHD in mouse model.

Results

Therapeutic functional manipulation of endogenous BAFF can improve acute GVHD during the early post-transplant period. In this study, BAFF was shown to increase the proportions of CD4+IL-17+, CD4+IL-6+ Th17, and CD4+IFN-γ+ Th1 cells and to reduce the proportion of regulatory T (Treg) cells. Furthermore, the belimumab therapy group showed increased B220+IgD+IgM+ mature B cells but decreased B220+IgD−IgM− memory B cells, B220+Fas+GL-7+ germinal center formation, and B220+IgD−CD138+ plasma cells. These results indicate that BAFF can alleviate acute GVHD by simultaneously regulating T and B cells. Interestingly, the BAFF level was higher in patients with acute GVHD after HSCT compared with patients receiving chemotherapy.

Conclusion

This study suggests that BAFF blockade might modulate CD4 +T-cell-induced acute GVHD early after allo-HSCT and the possibility of simultaneously controlling chronic GVHD, which may appear later after allo-HSCT.
Research on complex wake interference of aligned rotors considering the precone variation of the upstream wind turbine
Authors: Zhang Yuquan , Ji Renwei , Sun Ke , Zhang Zhi , Zheng Yuan , Zhang Jisheng , Zhang Xuewei , Rodriguez Emmanuel Fernandez
Published: December 2022

To understand the interaction wake effects of aligned horizontal-axis wind turbines, a refined and low-cost wake simulation framework is developed by combining the actuator line (AL) with a local dynamic Smagorinsky (LDS) model. Firstly, the published performance of the NREL-5MW wind turbine is used to corroborate the accuracy of the AL-LDS coupling model. Secondly, the research is extended to predict the interference between two tandem rotor wakes. The influence of the precone characteristics on the overall wake and power output of the tandem wind turbines is explored by modifying the upstream wind turbine and introducing the latest third-generation Ω vortex identification method in the post-processing procedure. According to results, the tandem wind turbines have complex wake interference, with the precone angle variation always reducing the global output power, and leading to an unstable downstream turbine wake. This is detrimental to system lifespan due to high performance fluctuation and stress and as well may have ecological implications due to sediment alteration. From results, an upwind turbine with precone angle (negative) can lead to higher downstream but lower upstream turbine performance, compared with a non-tilted turbine. Despite the optimal precone angle of the upstream wind turbine is 0°, a -2.5° proves more advantageous owing to the large flexible deformation of the turbine wingtips. The findings can serve as a continuous incentive for improving wind farm numerical simulation.
Study on particle cluster dynamics behavior in settling and the influence by fiber barrier
Authors: Bai Zhifeng , Li Mingzhong , Li Feng , Du Qiuying
Published: December 2022

The dispersion of particle clusters is relevant to a high concentration carrying fluid such as fracturing and drilling fluid, and the fiber-containing fluid could improve the carrying performance of particles. In the present study, the settling dynamics behavior of clusters is investigated using the CFD-DEM method. The numerical simulation method employed was able to accurately predict the deformation and velocity change rules, which express the cluster settling dynamics behavior. The velocity variation of particles is affected by hindrance and contact inside the cluster, and the velocity contrast leads to particle leakage and cluster deformation. The cluster will have regular shape changes and break up in the settlement process under gravity and fluid drag force. According to the sensitivity parameter analysis, the deformation of clusters is mainly affected by the fluid rheological properties. Different from glycerol, the settling cluster in viscoelastic HPG has a more complex dynamic behavior and a better fiber barrier effect. The fiber barrier between particles in the cluster can be regarded as a weakly constrained fiber grid structure. Due to the contact force, fiber grid structure formed in the cluster could effectively restrain the shape change and break up trend in the settlement process. The design also considers the influence of fiber and HPG concentration, and we analyze the settling velocity of the mixed-fiber cluster. Overall, the research on the cluster settling dynamics behavior is helpful in analyzing the effect of fiber-containing fluid in the carrying performance of particles.
His-Ala-Phe-Lys peptide from Burkholderia arboris possesses antifungal activity
Authors: Zhu Huajie , Xu Cuihong , Chen Yicun , Liang Yan
Published: December 2022

Burkholderia arboris, which belongs to the Burkholderia cepacia complex, has been shown to possess antifungal activity against several plant fungal pathogens; however, the antifungal compounds are yet to be identified. Here, we identified the antifungal compounds produced by B. arboris using genetic and metabolomic approaches. We generated a Tn5 transposon mutation library of 3,000 B. arboris mutants and isolated three mutants with reduced antifungal activity against the plant fungal pathogen Fusarium oxysporum. Among the mutants, the M464 mutant exhibited the weakest antifungal activity. In the M464 genome, the transposon was inserted into the cobA gene, encoding uroporphyrin-III methyltransferase. Deletion of the cobA gene also resulted in reduced antifungal activity, indicating that the cobA gene contributed to the antifungal activity of B. arboris. Furthermore, a comparison of the differential metabolites between wild type B. arboris and the ∆cobA mutant showed a significantly decreased level of tetrapeptide His-Ala-Phe-Lys (Hafk) in the ∆cobA mutant. Therefore, a Hafk peptide with D-amino acid residues was synthesized and its antifungal activity was evaluated. Notably, the Hafk peptide displayed significant antifungal activity against F. oxysporum and Botrytis cinerea, two plant pathogens that cause destructive fungal diseases. Overall, a novel antifungal compound (Hafk) that can be used for the biocontrol of fungal diseases in plants was identified in B. arboris.
Lumboperitoneal shunt surgery via continuous two-stage procedure: Technique notes and outcomes
Authors: Li Zhao , Wang Hao , Zhang Han , Yang Jiqi , Yang Xiaofeng , Wen Liang
Published: December 2022

Background

Lumboperitoneal shunt (LPS) is an effective procedure for managing communicating hydrocephalus. LPS is performed as a one-stage procedure with the patient placed in the lateral position or as a two-stage procedure in which the patient's position is changed. Both methods can be bothersome to neurosurgeons. We designed a continuous two-stage LPS procedure in which the operative sites did not need to be sterilized again, and the surgical drapes did not have to be changed after changing the patient's position. In this study, we analyzed this procedure in terms of the technical features and outcomes.

Methods

All patients from our institute who underwent LPS using the continuous two-stage procedure from October 2019 to August 2021 were reviewed retrospectively. The patient's demographic information, clinical features, operative data, and outcomes were analyzed.

Results

A total of 46 consecutive patients who underwent LPS using the continuous two-stage procedure were enrolled. The mean operative duration was 70.6 ± 12.7 min. The 180-day revision rate for these patients was 2.2% (1/46). Moreover, 76.1% of the patients (35/46) experienced clinical improvement after LPS during the 180-day follow-up, and 70.0% of the patients (32/46) experienced an improvement in neuroimaging.

Conclusion

We described a continuous two-stage LPS procedure. This method simplified the two-stage LPS procedure and maintained a low malfunction rate and shunt infection rate in our series.