bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Inflammatory Markers and Integrity of the Superior Longitudinal Fasciculus and the Inferior Longitudinal Fasciculus in Schizophrenia, from Prodromal Stages to Chronic Psychosis—A Cross-Sectional Study
Authors: Michalczyk Anna , Tyburski Ernest , Podwalski Piotr , Waszczuk Katarzyna , Rudkowski Krzysztof , Kucharska-Mazur Jolanta , Mak Monika , Rek-Owodziń Katarzyna , Plichta Piotr , Bielecki Maksymilian , Andrusewicz Wojciech , Cecerska-Heryć Elżbieta , Samochowiec Agnieszka , Misiak Błażej , Sagan Leszek , Samochowiec Jerzy
Published: January 2023

Chronic subclinical inflammation is believed to be an important factor in the pathogenesis of schizophrenia. Meta-analyses confirm the presence of increased levels of peripheral inflammatory markers (IM) in schizophrenia and its prodromal stages. Peripheral cytokines may affect the brain microstructure through chronic activation of microglia. Disruptions in the integrity of the superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILF) are commonly seen in patients with schizophrenia spectrum disorders. We therefore attempted to verify in a cross-sectional study whether there is a correlation between levels of peripheral IM and the integrity of these brain regions in healthy controls, from prodromal states and first episode psychosis to long-term schizophrenia. The integrity of white matter was measured using diffusion tensor imaging. Despite a broad analysis of six IM (CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ), we did not find any correlations with the integrity of the SLF or ILF in any of the analyzed groups (after correction for multiple comparisons). In conclusion, our study does not support the existence of a link between disrupted levels of peripheral IM and reduced integrity of ILF and SLF in schizophrenia spectrum disorders. However, prospective studies are needed to verify this over a long period of time.
Does the Measurement of Ejection Fraction Still Make Sense in the HFpEF Framework? What Recent Trials Suggest
Authors: Palazzuoli Alberto , Correale Michele , Iacoviello Massimo , Gronda Edoardo
Published: January 2023

Left ventricular ejection fraction (LVEF) is universally accepted as a cardiac systolic function index and it provides intuitive interpretation of cardiac performance. Over the last two decades, it has erroneously become the leading feature used by clinicians to characterize the left ventricular function in heart failure (HF). Notably, LVEF sets the basis for structural and functional HF phenotype classification in current guidelines. However, its diagnostic and prognostic role in patients with preserved or mildly reduced contractile function is less clear. This is related to several concerns due to intrinsic technical, methodological and hemodynamic limitations entailed in LVEF measurement that do not describe the chamber’s real contractile performance as expressed by pressure volume loop relationship. In patients with HF and preserved ejection fraction (HFpEF), it does not reflect the effective systolic function because it is prone to preload and afterload variability and it does not account for both longitudinal and torsional contraction. Moreover, a repetitive measurement could be assessed over time to better identify HF progression related to natural evolution of disease and to the treatment response. Current gaps may partially explain the causes of negative or neutral effects of traditional medical agents observed in HFpEF. Nevertheless, recent pooled analysis has evidenced the positive effects of new therapies across the LVEF range, suggesting a potential role irrespective of functional status. Additionally, a more detailed analysis of randomized trials suggests that patients with higher LVEF show a risk reduction strictly related to overall cardiovascular (CV) events; on the other hand, patients experiencing lower LVEF values have a decrease in HF-related events. The current paper reports the main limitations and shortcomings in LVEF assessment, with specific focus on patients affected by HFpEF, and it suggests alternative measurements better reflecting the real hemodynamic status. Future investigations may elucidate whether the development of non-invasive stroke volume and longitudinal function measurements could be extensively applied in clinical trials for better phenotyping and screening of HFpEF patients.
Prediction Models for Tinnitus Presence and the Impact of Tinnitus on Daily Life: A Systematic Review
Authors: Rademaker Maaike M. , Meijers Sebastiaan M. , Smit Adriana L. , Stegeman Inge
Published: January 2023

The presence of tinnitus does not necessarily imply associated suffering. Prediction models on the impact of tinnitus on daily life could aid medical professionals to direct specific medical resources to those (groups of) tinnitus patients with specific levels of impact. Models of tinnitus presence could possibly identify risk factors for tinnitus. We systematically searched the PubMed and EMBASE databases for articles published up to January 2021. We included all studies that reported on multivariable prediction models for tinnitus presence or the impact of tinnitus on daily life. Twenty-one development studies were included, with a total of 31 prediction models. Seventeen studies made a prediction model for the impact of tinnitus on daily life, three studies made a prediction model for tinnitus presence and one study made models for both. The risk of bias was high and reporting was poor in all studies. The most used predictors in the final impact on daily life models were depression- or anxiety-associated questionnaire scores. Demographic predictors were most common in final presence models. No models were internally or externally validated. All published prediction models were poorly reported and had a high risk of bias. This hinders the usability of the current prediction models. Methodological guidance is available for the development and validation of prediction models. Researchers should consider the importance and clinical relevance of the models they develop and should consider validation of existing models before developing new ones.
Double Plating for Complex Proximal Humeral Fractures: Clinical and Radiological Outcomes
Authors: Michel Philipp , Raschke Michael , Katthagen J. , Schliemann Benedikt , Reißberg Isabelle , Riesenbeck Oliver
Published: January 2023

Double plating for proximal humeral fractures (PHF) is an option to increase the primary fixation stability. Clinical data is missing for assessment of clinical and radiological outcome, as well as complications. We retrospectively examined 35 patients with unilateral PHF, who were treated with double plating for PHF between 2013 and 2019. The mean age was 59.5 ± 12 years and the leading fracture type was a varus dislocation (Resch type IV in 55.3%). A head-split was present in 22.9% of the cases. The primary outcome measurement was the radiological neck shaft angle (NSA). The radiological follow-up was 21 ± 16.6 months and the NSA did not differ between the intraoperative and follow-up time point (131.5 ± 6.9° vs. 136.6 ± 13.7°; p = 0.267). The clinical follow-up was 29.5 ± 15.3 months. The Constant-score was 78.5 ± 17 points, the simple-shoulder-test (SST) was 9.3 ± 3.2 points and the subjective shoulder value (SSV) was 78.8 ± 19.5%. The over-all complication rate was 31.4%, and without stiffness 14.3%. An avascular necrosis occurred in two patients (5.7%). In conclusion, this study shows good radiological and functional outcomes after double plating of highly complex proximal humeral fractures, while the complication rate is comparable to the literature. Double plating is a viable option especially for younger patients with complex fractures as a potential alternative to fracture arthroplasty.
Viral Infections May Be Associated with Henoch–Schönlein Purpura
Authors: Nikolaishvili Mariam , Pazhava Ani , Di Lernia Vito
Published: January 2023

Henoch–Schönlein purpura or IgA vasculitis is the most common type of pediatric vasculitis that may affect adults as well. It is classified as a type of small-vessel vasculitis. It can cause cutaneous and systemic symptoms with a minority of patients developing kidney failure. Little is known about the specific pathophysiology of this disorder, except that it is believed to occur in individuals with abnormally glycosylated IgA1. Serum aberrant IgA1 may form large antigen–antibody complexes which, due to a defective clearance, are able to deposit in the small vessels of the skin, kidney, gut, and joints. A variety of factors, including infectious agents, drugs, and vaccines, have been identified as potential triggers. The majority of cases are preceded by upper respiratory tract infections, and seasonal variations suggest a link with many pathogens. The etiologic agent most frequently associated with IgA vasculitis historically have been group A β-hemolytic streptococcus and common respiratory tract viruses. However, during the current coronavirus pandemic, SARS-CoV-2 infection was identified as a main trigger factor. In addition, IgA vasculitis has been observed following COVID-19 immunization. This review provides insights into the state of the art on the relationship between viral infections, viral vaccines, and Henoch–Schönlein purpura.
Electrocardiographic Time-Intervals Waveforms as Potential Predictors for Severe Acute Kidney Injury in Critically Ill Patients
Authors: Corradi Francesco , Santori Gregorio , Brusasco Claudia , Robba Chiara , Wong Adrian , Di Nicolò Pierpaolo , Tecchi Ludovica , Dazzi Federico , Taddei Erika , Isirdi Alessandro , Coccolini Federico , Forfori Francesco , Tavazzi Guido ,   on behalf of UCARE Research Group
Published: January 2023

Background: Acute kidney injury (AKI) is common in critically ill patients admitted to intensive care units (ICU) and is frequently associated with poorer outcomes. Hence, if an indicator is available for predicting severe AKI within the first few hours of admission, management strategies can be put into place to improve outcomes. Materials and methods: This was a prospective, observational study, involving 63 critically ill patients, that aimed to explore the diagnostic accuracy of different Doppler parameters in predicting AKI in critically ill patients from a mixed ICU. Participants were enrolled at ICU admission. All underwent ultrasonographic examinations and hemodynamic assessment. Renal Doppler resistive index (RDRI), venous impedance index (VII), arterial systolic time intervals (a-STI), and venous systolic time intervals (v-STI) were measured within 2 h from ICU admission. Results: Cox proportional hazards models, including a-STI, v-STI, VII, and RDRI as independent variables, returned a-STI as the only putative predictor for the development of AKI or severe AKI. An overall statistically significant difference (p < 0.001) was observed in the Kaplan–Meier plots for cumulative AKI events between patients with a-STI higher or equal than 0.37 and for cumulative severe AKI-3 between patients with a-STI higher or equal than 0.63. As assessed by the area under the receiver operating curves (ROC) curves, a-STI performed best in diagnosing any AKI and/or severe AKI-3. Positive correlations were found between a-STI and the N-terminal brain natriuretic peptide precursor (NT-pro BNP) (ρ = 0.442, p < 0.001), the sequential organ failure assessment (SOFA) score (ρ: 0.361, p = 0.004), and baseline serum creatinine (ρ: 0.529, p < 0.001). Conclusions: Critically ill patients who developed AKI had statistically significant different a-STI (on admission to ICU), v-STI, and VII than those who did not. Moreover, a-STI was associated with the development of AKI at day 5 and provided the best diagnostic accuracy for the diagnosis of any AKI or severe AKI compared with RDRI, VII, and v-STI.
A 20-Year Retrospective Study of Children and Adolescents Treated by the Three-in-One Procedure for Patellar Realignment
Authors: Trisolino Giovanni , Depaoli Alessandro , Gallone Giovanni , Ramella Marco , Olivotto Eleonora , Zarantonello Paola , Stallone Stefano , Persiani Valentina , Casadei Giacomo , Rocca Gino
Published: January 2023

Background: Patellar instability is the most common disorder of the knee during childhood and adolescence. Surgical treatment significantly reduces the rate of redislocation, but the underlying pathologies and pattern of instability may affect the results. We aimed to report the clinical and functional outcomes of the three-in-one procedure for patellar realignment in a cohort of skeletally immature patients with or without syndromes and various patterns of chronic patellar instability. Methods: We retrospectively investigated 126 skeletally immature patients (168 knees) affected by idiopathic or syndromic patellar instability, who underwent patella realignment through a three-in-one procedure. We classified the instability according to the score proposed by Parikh and Lykissas. Results: Patellar dislocation was idiopathic in 71 patients (94 knees; 56.0%) and syndromic in 55 (74 knees; 44.0%). The mean age at surgery was 11.5 years (range 4–18) and was significantly lower in syndromic patients. Syndromic patients also exhibited more severe clinical pattern at presentation, based on the Parikh and Lykissas score. The mean follow-up was 5.3 years (range 1.0–15.4). Redislocation occurred in 19 cases, with 10 cases requiring further realignment. The Parikh and Lykissas score and the presence of congenital ligamentous laxity were independent predictors of failure. A total of 22 knees in 18 patients required additional surgical procedures. The post-operative Kujala score was significantly lower in patients with syndromic patellar instability. Conclusions: The type of instability and the presence of underlying syndromes negatively affect the rate of redislocation and the clinical and functional outcome following patellar realignment through the three-in-one procedure. We recommend the consideration of alternative surgical strategies, especially in children with severe syndromic patellar dislocation.
A Systematic Review and Meta-Analysis of the Brief Cognitive Assessment for Multiple Sclerosis (BICAMS) International Validations
Authors: Potticary Hannah , Langdon Dawn
Published: January 2023

Cognitive impairment is a prevalent and debilitating symptom of multiple sclerosis (MS) but is not routinely addressed in clinical care. The Brief Cognitive Assessment for Multiple Sclerosis (BICAMS) was developed in 2012 to screen and monitor MS patients’ cognition. This systematic review and meta-analysis aimed to identify, synthesise, and critically appraise current BICAMS’ international validations. The literature search was conducted using PubMed, PsycINFO and Web of Science electronic databases in August 2022. Quantitative, peer-reviewed adult studies, which followed the BICAMS international validation protocol and were published in English, were included. The search identified a total of 203 studies, of which 26 were eligible for inclusion. These reported a total of 2833 adults with MS and 2382 healthy controls (HC). The meta-analysis showed that BICAMS identified impaired cognitive functioning in adults with MS compared to HC for all three subtests: information processing speed (g = 0.854, 95% CI = 0.765, 0.944, p < 0.001), immediate verbal recall (g = 0.566, 95% CI = 0.459, 0.673, p < 0.001) and immediate visual recall (g = 0.566, 95% CI = 0.487, 0.645, p < 0.001). Recruitment sites and strategies limit the generalisability of results. BICAMS is a valid and feasible international MS cognitive assessment.
The Urine Calcium/Creatinine Ratio and Uricemia during Hyponatremia of Different Origins: Clinical Implications
Authors: Decaux Guy , Musch Wim
Published: January 2023

Background: Chronic hyponatremia is known to be associated with osteoporosis. It has been shown that chronic hyponatremia increases bone resorption in an attempt to release body stores of exchangeable sodium by different mechanisms. We wanted to know the calciuria of patients with hyponatremia of different origins. Material and Methods: We made a retrospective study of 114 consecutive patients with asymptomatic hyponatremia of different origins with the usual serum and urine chemistry. Result: In hyponatremia due to SIADH, we had a high urine calcium/creatinine ratio of 0.23 ± 0.096 while in patients with salt depletion the UCa/UCr ratio was low (0.056 ± 0.038), in patients with hyponatremia secondary to thiazide intake the value was also low (0.075 ± 0.047) as in hypervolemic patients (0.034 ± 0.01). In hyponatremia due to polydipsia, the value was high (0.205 ± 0.10). Correction of hyponatremia in the euvolemic patients was associated with a significant decrease in the UCa/UCr ratio. In patients with hyponatremia secondary to thiazide intake, we noted that in the patients with low uric acid levels (<4 mg/dL, suggesting euvolemia) we also observed a low UCa/UCr (<0.10). In nine patients with chronic SIADH (SNa 125.1 ± 3.6 mEq/L), the 24 h urine calcium excretion was 275 ± 112 mg and decreased to 122 ± 77 mg (p < 0.01) after at least 2 weeks of treatment. Conclusions: Patients with chronic hyponatremia due to SIADH usually have a high UCa/UCr ratio (>0.15). This is also observed in hyponatremia secondary to polydipsia. Patients with thiazide-induced hyponatremia usually have low UCa/UCr levels and this is the case even among those with a biochemistry similar to that in SIADH (uric acid < 4 mg/dL).
A Modified MPS Method with a Split-Pressure Poisson Equation and a Virtual Particle for Simulating Free Surface Flows
Authors: Li Date , Zhang Huaixin , Qin Guangfei
Published: January 2023

As a Lagrangian mesh-free method, the moving particle semi-implicit (MPS) method can easily handle complex incompressible flow with a free surface. However, some deficiencies of the MPS method, such as inaccurate results, unphysical pressure oscillation, and particle thrust near the free surface, still need to be further resolved. Here, we propose a modified MPS method that uses the following techniques: (1) a modified MPS scheme with a split-pressure Poisson equation is proposed to reproduce hydrostatic pressure stably; (2) a new virtual particle technique is developed to ensure the symmetrical distribution of particles on the free surface; (3) a Laplacian operator that is consistent with the original gradient operator is introduced to replace the original Laplacian operator. In addition, a two-judgment technique for distinguishing free surface particles is introduced in the proposed MPS method. Four free surface flows were adopted to verify the proposed MPS method, including two hydrostatic problems, a dam-breaking problem, and a violent sloshing problem. The enhancement of accuracy and stability by these improvements was demonstrated. Moreover, the numerical results of the proposed MPS method showed good agreement with analytical solutions and experimental results.
Field Measurement and Numerical Study on the Effects of Under-Excavation and Over-Excavation on Ultra-Deep Foundation Pit in Coastal Area
Authors: Cui Jifei , Yang Zhenkun , Azzam Rafig
Published: January 2023

An ultra-deep L-shape foundation pit in a coastal area has recently been constructed and monitored. The project overview, geological conditions, excavation sequence and monitoring scheme are introduced in detail. The deformation of the retaining structure and surrounding strata are analyzed in detail through the measured data and 3D numerical simulation. The results show that the exceptional performance of the current project is due to the combination of under-excavation and over-excavation during construction. The under-excavation procedure restrained the wall deflections at the middle part of the diaphragm wall, making the corner effects at the corresponding side inapparent. Both the under-excavation and over-excavation procedure can only influence the performance of the excavation in close proximity, while having negligible impacts on the normally excavated areas. Based on the results of this study, practical suggestions are given to improve the performance of similar excavations in the future.
Design of Control System for Multistage Distillation Seawater Desalination Device Driven by Photovoltaic-Thermal
Authors: Yan Jiaqi , Qiu Chengjun , Wang Yuangan , Wu Ning , Qu Wei , Zhuang Yuan , Yan Guohui , Wang Ping , Zhang Ruoyu , Yan Yirou , Deng Ruonan , Luo Jiuqiang , Gao Jiaqi , Wu Yuxuan
Published: January 2023

This research proposes a seawater desalination system driven by photovoltaic and solar thermal energy for remote regions such as islands and seaside villages where fresh water is not accessible. The performance of this system is demonstrated through experiments, and the main concerns are the output of the photovoltaic power generation system, power quantity, water yield, and the loads under different solar irradiance and temperature. In this system, a PLC is used as the controller to adjust the water pump by the collection and processing of sensor data. A load switching time system is designed to select different operating schemes under different environments in order to save energy. The control method of this system is developed to ensure that the photovoltaic power generation system does not undervoltage while maintaining the normal operation of the desalination system. An improved Perturbation and Observation (P&O) algorithm is also proposed as a new Maximum Point Power Tracking (MPPT) method to solve the problem of misjudgment and oscillation after tracking the maximum power point (MPP) in the traditional P&O algorithm. The simulation test in the MATLAB/Simulink environment shows that when external irradiance changes, the improved P&O algorithm can track the MPP faster than the traditional P&O algorithm, and the amplitude of oscillation on the MPP is smaller. The hardware experiments show that this system can operate stably and flexibly, and it is capable of producing 5.18 kWh of electric energy and 335.81 kg of freshwater per day. The maximum yield of the unit can reach 565.75 kg per day and the maximum daily power generation is 8.12 kWh.
Analysis of the Descent Process and Multi-Objective Optimization Design of a Benthic Lander
Authors: Zhang Qiao , Dong Chunming , Shao Zongze , Zhou Donghui
Published: January 2023

The growing need for deep-sea biological research and environmental monitoring has expanded the demand for benthic landers. Compared with remotely operated vehicles (ROVs) and autonomous underwater vehicles (AUVs), benthic landers can reduce overall operation cost and also possess longer endurance. Configuring a suitable descent velocity is important for benthic lander designs, helping them avoid retrieval failure and improve sea trial efficiencies. In this study, an effective scheme for the configuration and optimization of a self-developed benthic lander was outlined. First, the structural characteristics of the benthic lander were analyzed, and then a dynamic model was established. Second, the hydrodynamic coefficients of the benthic lander during its descent process were calculated using computational fluid dynamics (CFD) methods. Third, the MATLAB Simulink simulation environment was used to solve the dynamic model, and then the multi-objective optimization algorithm was introduced for the optimization design. Finally, the model was validated based on sea trial data, which demonstrated that the designed configuration and optimization scheme were correct and efficient. Collectively, this work provides a useful reference for the rational configuration and practical application of benthic landers.
Second-Generation Enamine-Type Schiff Bases as 2-Amino Acid-Derived Antifungals against Fusarium oxysporum: Microwave-Assisted Synthesis, In Vitro Activity, 3D-QSAR, and In Vivo Effect
Authors: Borrego-Muñoz Paola , Cardenas Diego , Ospina Felipe , Coy-Barrera Ericsson , Quiroga Diego
Published: January 2023

In this manuscript, the synthesis of enamine-type Schiff bases 1–48 derived from the amino acids L-Ala, L-Tyr, and L-Phe was carried out. Their in vitro activity and in vivo protective effect against Fusarium oxysporum were also evaluated through mycelial growth inhibition and disease severity reduction under greenhouse conditions. The in vitro activity of test compounds 1–48 showed half-maximal inhibitory concentrations (IC50) at different levels below the 40 mM range. Deep analysis of the IC50 variations indicated that the size of the substituent on the acetylacetone derivatives and the electronic character on the cyclohexane-3-one fragment influenced the antifungal effect. 3D-QSAR models based on atoms (atom-based approach) were built to establish the structure–activity relationship of the test Schiff bases, showing a good correlation and predictive consistency (R2 > 0.70 and Q2 > 0.60). The respective contour analysis also provided information about the structural requirements for potentiating their antifungal activity. In particular, the amino acid-related fragment and the alkyl ester residue can favor hydrophobic interactions. In contrast, the nitrogen atoms and enamine substituent are favorable regions as H-donating and electron-withdrawing moieties. The most active compounds (40 and 41) protected cape gooseberry plants against F. oxysporum infection (disease severity index < 2), involving adequate physiological parameters (stomatal conductance > 150 mmol/m2s) after 45 days of inoculation. These promising results will allow the design of novel Schiff base-inspired antifungals using 2-amino acids as precursors.
Volatile Metabolites in Lavage Fluid Are Correlated with Cytokine Production in a Valley Fever Murine Model
Authors: Higgins Keppler Emily A. , Van Dyke Marley C. Caballero , Mead Heather L. , Lake Douglas F. , Magee D. Mitchell , Barker Bridget M. , Bean Heather D.
Published: January 2023

Coccidioides immitis and Coccidioides posadasii are soil-dwelling fungi of arid regions in North and South America that are responsible for Valley fever (coccidioidomycosis). Forty percent of patients with Valley fever exhibit symptoms ranging from mild, self-limiting respiratory infections to severe, life-threatening pneumonia that requires treatment. Misdiagnosis as bacterial pneumonia commonly occurs in symptomatic Valley fever cases, resulting in inappropriate treatment with antibiotics, increased medical costs, and delay in diagnosis. In this proof-of-concept study, we explored the feasibility of developing breath-based diagnostics for Valley fever using a murine lung infection model. To investigate potential volatile biomarkers of Valley fever that arise from host–pathogen interactions, we infected C57BL/6J mice with C. immitis RS (n = 6), C. posadasii Silveira (n = 6), or phosphate-buffered saline (n = 4) via intranasal inoculation. We measured fungal dissemination and collected bronchoalveolar lavage fluid (BALF) for cytokine profiling and for untargeted volatile metabolomics via solid-phase microextraction (SPME) and two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC-TOFMS). We identified 36 volatile organic compounds (VOCs) that were significantly correlated (p < 0.05) with cytokine abundance. These 36 VOCs clustered mice by their cytokine production and were also able to separate mice with moderate-to-high cytokine production by infection strain. The data presented here show that Coccidioides and/or the host produce volatile metabolites that may yield biomarkers for a Valley fever breath test that can detect coccidioidal infection and provide clinically relevant information on primary pulmonary disease severity.
Acknowledgment to the Reviewers of Journalism and Media in 2022
Authors:   Journalism and Media Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Strengthening Formal Credit Access and Performance through Financial Literacy and Credit Terms in Micro, Small and Medium Businesses
Authors: Widyastuti Maria , Ferdinand Deograsias Yoseph Yustinianus , Hermanto Yustinus Budi
Published: January 2023

This study aims to test financial literacy and credit conditions in determining formal credit access to determine the performance of MSMEs. This research includes the type of associative research that is accompanied by hypothesis testing. This research was conducted on MSMEs of as many as 324 creative industry players in four cities in East Java (Mojokerto, Pasuruan, Gresik, and Sidoarjo) with a sample size of 100 actors who had accessed formal credit using the stratified random sampling method for data collection. The results of Smart PLS analysis show that financial literacy and credit terms directly and significantly affect access to formal credit and MSME performance; formal credit access directly and significantly affects MSME performance. Likewise, financial literacy and credit terms indirectly affect the performance of MSMEs. These results mean that financial literacy and credit terms have a strategic role in explaining why access to formal credit is growing and is attracting MSMEs to strengthen capital to improve performance.
Is More Financial Literacy Always Beneficial? An Investigation through a Mediator
Authors: Chen Biwei , Giannikos Christos I. , Lou Jun
Published: January 2023

We study the impact of financial literacy on financial risk preference. When financial literacy is measured jointly by actual and self-assessed scores, we find compelling evidence of a valley-shaped relationship between actual financial literacy and risk preference. At a given level of self-assessment, as actual financial literacy increases, the willingness to take risks initially decreases and then rises. Actual financial literacy is modeled to impact risk preference through self-assessed financial literacy, the mediator; this mediation effect is significant. Furthermore, increasing actual financial literacy has a positive (negative) effect in underconfident (overconfident) individuals on several financial behaviors.
Acknowledgment to the Reviewers of Journal of Theoretical and Applied Electronic Commerce Research in 2022
Authors: JTAER Editorial Office JTAER Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Interaction Mechanism of Fe, Mg and Mn in Karst Soil-Mango System
Authors: Xu Can , Yang Hui , Huang Chao , Lan Mingguo , Zou Zujian , Zhang Fagui , Zhang Liankai
Published: January 2023

Manganese (Mn), an essential trace element for plants in which it is involved in redox reactions as a cofactor for many enzymes, represents an important factor in environmental contamination. Excess Mn can lead to toxicity conditions in natural and agricultural sites. Manganese toxicity is one of the most severe growth limiting factors in acid soil, which accounts for 21% of the total arable lands in China. The more significant part of Mn-toxicity is its interactions with other mineral elements, in particular with phosphorus (P), calcium (Ca) and iron (Fe). The application of P or Ca can be beneficial in the detoxification of manganese, whereas Mn seems to interfere with Fe metabolism. Manganese toxicity varies with plant species, nutrients, and the soil environment. Mango is the main economic fruit in the karst area of the subtropical region of China. The karst soil in the mango orchard is characterized by high Fe, Mn and Mg. In order to explore the interaction among Fe, Mg, and Mn in karst soil and mango systems under high Mn conditions, a typical mango orchard in the karst depression landform in Baise in southern China was selected to study the effects of Fe and Mg on the toxic expression of Mn in mango plants and the interaction mechanism of Fe-Mn-Mg in mango plants. The results show that: (1) the mango growth status is closely correlated with Fe2+ (active iron) and Mg under the same soil Mn concentration; (2) The black spots on mango leaves were mainly caused by Fe and Mn. There is a lot of Fe3+ and Mn3+ in the black spots, which accounts for more than 90% of the total; (3) In addition, the studies also showed that the Fe and Mg inhibited the expression of Mn toxicity in mango. Conclusively, the interaction effect of Fe, Mn, and Mg is an important factor that affects mango growth, which can indicate the status of the soil and plants.
Measuring the Relationship between Bilingual Exposure and Social Attentional Preferences in Autistic Children
Authors: Davis Rachael , Rabagliati Hugh , Montgomery Lewis , Sorace Antonella , Fletcher-Watson Sue
Published: January 2023

Background: Autistic children show reduced attentional preferences to social stimuli early in development, and these differences have consequences on a range of social domains. One factor that could influence development in those processes is bilingualism. Parents and practitioners frequently voice unfounded concerns that bilingualism could cause delays in autistic children, yet there is little evidence to dispute this idea. While there are studies focusing on the impact of bilingualism on cognition in autistic children, no research has focused on the relationship between bilingualism and social attention. Aims: This study therefore investigated the impact of bilingual exposure on social attention in autistic (n = 33) and neurotypical children (n = 42) aged 6–13 years. Rather than a monolingual/bilingual comparison, participants had varying degrees of bilingual exposure, and exposure was treated as a continuous variable. Participants completed an eye-tracking task measuring visual attention to interacting versus non-interacting human figures. Results: Bilingual exposure did not affect dwell time to interacting or non-interacting figures for the neurotypical or autistic groups. However, there was a three-way interaction between diagnosis, figure type and vocabulary scores on dwell time. Conclusions: Higher vocabulary scores in neurotypical participants was associated with significantly less dwell time to non-interacting stimuli. This is the first study to assess the effects of bilingualism on social attention; here, concerns of bilingualism are not upheld.
The Grammaticalization of the Discourse Marker genre in Swiss French
Authors: Deng Delin
Published: January 2023

By conducting an apparent-time analysis of the OFROM corpus collected in Francophone Switzerland, this study examined the use of genre as discourse marker in the speech of 306 French L1 speakers. First, we examined the effect of extralinguistic factors on the discursive use of genre. The logistic mixed-effects regression analysis results revealed that the emerging use of genre is indeed an ongoing change led by female speakers in Swiss French. This use was favored by monolinguals in Francophone Swiss. Second, we examined the vowel reduction of the DM genre in the corpus. Our results revealed that speakers who received only a high school education favor the vowel reduction in the DM genre the most. Given the high percentage of phonological reduction in the DM genre, we believe that the grammaticalization of this particle has reached its advanced stage in Swiss French. Compared to previous findings on the emerging use of genre in Hexagonal French, we suggested that the grammaticalization of the particle genre in Swiss French may be independent of that in Hexagonal French. The grammaticalization in Swiss French was much more advanced than in Hexagonal French. This study supplied comparable results on the grammaticalization of the same particle in two different Francophone countries.
Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection
Authors: Oswal Neelam , Thangavel Hariprasad , Lizardo Kezia , Dhanyalayam Dhanya , Sidrat Tabinda , Salgame Padmini , Nagajyothi Jyothi
Published: January 2023

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection persists as a leading cause of mortality and morbidity globally, especially in developing and underdeveloped countries. The prevalence of TB-DM (diabetes mellitus) is higher in low- and middle-income countries where TB and DM are most prevalent. Epidemiological data suggest that slight obesity reduces the risk of TB, whereas DM increases the risk of pulmonary TB. Diets can alter the levels of body fat mass and body mass index by regulating systemic adiposity. Earlier, using a transgenic Mtb-infected murine model, we demonstrated that loss of body fat increased the risk of pulmonary bacterial load and pathology. In the present study, we investigated whether increased adiposity alters pulmonary pathology and bacterial load using C57BL/6 mice infected with HN878 Mtb strain and fed a medium-fat diet (MFD). We analyzed the effects of MFD on the lung during acute and chronic infections by comparing the results to those obtained with infected mice fed a regular diet (RD). Histological and biochemical analyses demonstrated that MFD reduces bacterial burden by increasing the activation of immune cells in the lungs during acute infection and reduces necrosis in the lungs during chronic infection by decreasing lipid accumulation. Our data suggest that slight adiposity likely protects the host during active TB infection by regulating immune and metabolic conditions in the lungs.
Emerging Biomarkers for Predicting Clinical Outcomes in Patients with Heart Disease
Authors: Pál Krisztina , Mănescu Ion-Bogdan , Lupu Silvia , Dobreanu Minodora
Published: January 2023

Cardiovascular disease is most frequently caused by the development and progression of atherosclerosis. When coronary arteries are afflicted, and the stenoses caused by atherosclerotic plaques are severe enough, the metabolic supply-and-offer balance is disturbed, leading to myocardial ischemia. If atherosclerotic plaques become unstable and local thrombosis develops, a myocardial infarction occurs. Sometimes, myocardial ischemia and infarction may result in significant and irreversible heart failure. To prevent severe complications, such as acute coronary syndromes and ischemia-related heart failure, extensive efforts have been made for developing biomarkers that would help identify patients at increased risk for cardiovascular events. In this two-part study, we attempted to provide a review of existing knowledge of blood biomarkers that may be used in this setting. The first part of this work was dedicated to conventional biomarkers, which are already used in clinical practice. In the second part, here presented, we discuss emerging biomarkers which have not yet become mainstream.
Effects of Home-Based Exercise Training on Cardiac Autonomic Neuropathy and Metabolic Profile in Diabetic Hemodialysis Patients
Authors: Michou Vassiliki , Liakopoulos Vassilios , Roumeliotis Stefanos , Roumeliotis Athanasios , Anifanti Maria , Tsamos Georgios , Papagianni Aikaterini , Zempekakis Pantelis , Deligiannis Asterios , Kouidi Evangelia
Published: January 2023

Background: This study aimed to investigate the effects of a home-based exercise training program on Cardiac Autonomic Neuropathy (CAN) and metabolic profile in Diabetic Kidney Disease (DKD) patients undergoing maintenance hemodialysis (HD). Method: Twenty-eight DKD patients undergoing hemodialysis were randomly assigned into two groups. The exercise (EX) group followed a 6-month combined exercise training program at home, while the control (CO) group remained untrained. All participants at baseline and the end of the study underwent cardiopulmonary exercise testing (CPET), biochemical tests for glucose and lipid profile, and 24-h electrocardiographic monitoring for heart rate variability (HRV) analysis and heart rate turbulence (HRT). Results: At the end of the study, compared to the CO, the EX group showed a significant increase in serum high-density lipoprotein (HDL) by 27.7% (p = 0.01), peak oxygen uptake (VO2peak) by 9.3% (p < 0.05), the standard deviation of R-R intervals (SDNN) by 34.3% (p = 0.03), percentage of successive RR intervals higher than 50ms (pNN50) by 51.1% (p = 0.02), turbulence slope (TS) index by 18.4% (p = 0.01), and decrease in (glycated hemoglobin) HbA1c by 12.5% (p = 0.04) and low-frequency power LF (ms2) by 29.7% (p = 0.01). Linear regression analysis after training showed that VO2peak was correlated with SDNN (r = 0.55, p = 0.03) and HF (r = 0.72, p = 0.02). Multiple regression analysis indicated that the improvement of sympathovagal balance and aerobic capacity depended on patients’ participation in exercise training. Conclusion: In conclusion, a 6-month home-based mixed-type exercise program can improve cardiac autonomic function and metabolic profile in DKD patients on HD.
Characteristics of Aflatoxin B1 Degradation by Stenotrophomonas acidaminiphila and It’s Combination with Black Soldier Fly Larvae
Authors: Suo Jianghua , Liang Tingting , Zhang Haixu , Liu Kun , Li Xinfeng , Xu Kun , Guo Jianlai , Luo Qiujiang , Yang Sen
Published: January 2023

Aflatoxin B1 (AFB1) is a common mycotoxin contaminant in cereals that causes severe economic losses and serious risks to the health of humans and animals. In this paper, we investigated the characteristics of AFB1 degradation by black soldier fly larvae (BSFL) combined with commensal intestinal microorganisms. Germ-free BSFL and non-sterile BSFL were reared on peanut meal spiked with AFB1 for 10 days. The result showed that germ-free BSFL and non-sterile BSFL could achieve 31.71% and 88.72% AFB1 degradation, respectively, which indicated the important role of larvae gut microbiota in AFB1 degradation. Furthermore, twenty-five AFB1-degrading bacteria were isolated from BSFL gut, and S. acidaminiphila A2 achieved the highest AFB1 degradation, by 94%. When S. acidaminiphila A2 was re-inoculated to BSFL, the detrimental effect of AFB1 on the growth performance of BSFL was alleviated, and complete AFB1 degradation in peanut meal was obtained. In conclusion, the present study may provide a strategy to degrade AFB1 in feedstuff through bioconversion with BSFL in combination with gut-originated AFB1-degrading bacteria, while providing a sustainable insect protein and fat source to animals.
Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
Authors: Mohammadi Iman , Sadeghi Masoud , Tajmiri Golnaz , Brühl Annette Beatrix , Sadeghi Bahmani Laleh , Brand Serge
Published: January 2023

Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells. Herein, a systematic review and meta-analysis checked the changes in serum/plasma levels of omentin-1 (OM-1: an adipokine) and orexin-A (OXA: a neuropeptide) in adults (age > 18 years old) with OSA (aOSA) compared to controls. Materials and methods: Four databases (Cochrane Library, PubMed, Web of Science, and Scopus) were systematically searched until 14 November 2022, without any restrictions. The Joanna Briggs Institute (JBI) critical appraisal checklist adapted for case–control studies was used to assess the quality of the papers. The effect sizes were extracted using the Review Manager 5.3 software for the blood levels of OM-1 and OXA in aOSA compared with controls. Results: Thirteen articles, with six studies for OM-1 levels and eight for OXA levels, were included. The pooled standardized mean differences were −0.85 (95% confidence interval (CI): −2.19, 0.48; p = 0.21; I2 = 98%) and −0.20 (95%CI: −1.16, 0.76; p = 0.68; I2 = 96%) for OM-1 and OXA levels, respectively. Among the studies reporting OM-1, five were high and one was moderate quality. Among the studies reporting OXA, six were moderate, one was high, and one was low quality. Based on the trial sequential analysis, more participants are needed to confirm the pooled results of the analyses of blood levels of OM-1 and OXA. In addition, the radial plot showed outliers as significant factors for high heterogeneity. Conclusions: The main findings indicated a lack of association between the blood levels of OM-1 and OXA and OSA risk. Therefore, OM-1 and OXA did not appear to be suitable biomarkers for the diagnosis and development of OSA.
Acknowledgment to the Reviewers of Literature in 2022
Authors:   Literature Editorial Office
Published: January 2023

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Tribological Properties of Protic Ionic Liquid as an Additive in Aqueous Glycerol Solution for Ruby-Bearing Steel Tribo-Contact
Authors: Kreivaitis Raimondas , Gumbytė Milda , Kupčinskas Artūras , Treinytė Jolanta , Andriušis Albinas
Published: January 2023

Owing to their low cost and environmentally friendly nature, water-based lubricants have benefits over oil-based ones. However, the appropriate additive package is indispensable in improving its tribological properties. In the current study, we have investigated the friction and wear reduction ability of bis(2-hydroxyethyl) ammonium oleate protic ionic liquid (PIL) in a glycerol aqueous lubricating fluid. The tribo-tests were performed using a ruby–steel friction pair acting in reciprocation mode. The coefficient of friction and wear were the main characteristics of the evaluation. Analysis of the physical properties of the investigated lubricating samples and worn surface analysis were performed to reveal a more detailed picture. The study shows that the investigated PIL can significantly reduce friction and wear. The most suitable concentration of PIL was 0.5%, where friction and wear were reduced 2.6 and 15.8 times, respectively. Using the investigated PIL facilitates a sliding coefficient of friction as low as 0.039. It was hypothesized that the formation of the adsorption layer and metal soap was responsible for this. Further studies could be directed toward higher load and speed applications.
Influence of Solid Filler on the Rheological Properties of Propellants Based on Energetic Thermoplastic Elastomer
Authors: Zhang Jing , Wang Zhen , Sun Shixiong , Luo Yunjun
Published: January 2023

Glycidyl azide polymer-energetic thermoplastic elastomer propellant (GAP-ETPE) has high development prospects as a green solid propellant, although the preparation of GAP-ETPE with excellent performance is still a challenge. Focusing on the demand of high-strength solid propellants for free-loading rocket motors, a GAP-ETPE model propellant with excellent overall performance was prepared in this work, and the influence of adhesive structure characteristics on its fluidity was studied. Furthermore, the influence of filler on the rheological properties of the model propellant was investigated by introducing hexogen (RDX) and Al, and a corresponding two-phase model was established. The results may provide a reference for the structural design, molding process, and parameter selection of high-performance GAP-based green solid propellants.