bluuebunny/crossref_metadata_2025 huggingface dataset:
Autosomal Dominant Tubulointerstitial Kidney Disease Due to UMOD Mutation: A Two-Case Report and Literature Review
Authors: Liang Dandan , Liang Shaoshan , Zhang Mingchao , Gao Erzhi , Zhang Zhihong , Jin Ying , Xu Feng , Zeng Caihong
Published: August 2019

Autosomal dominant tubulointerstitial kidney disease due to UMOD (encoding uromodulin) mutation (ADTKD-UMOD) is a rare hereditary disease. In the present study, we reported 2 ADTKD cases with confirmed UMOD mutations (Arg185His, Trp258Gly) by gene testing. They were young men and presented with hyperuricemia and renal dysfunction with no hematuria or proteinuria. Renal histology showed chronic tubulointerstitial nephropathy with fibrillar inclusions in the cells of distal tubules. Electron microscopy illustrated extensive bundled and cystic endoplasmic reticulum. Immunohistological analysis confirmed intracytoplasmic aggregates of uromodulin in the distal tubules. Since ADTKD-UMOD is an underdiagnosed disease, electron microscopy and immunohistochemical staining for uromodulin are helpful in the diagnosis of ADTKD-UMOD and genetic analysis is the gold standard.
Plasmapheresis for the Treatment of Crescentic Postinfectious Glomerulonephritis: A Case Report
Authors: Gökalp Cenk , Turkoglu Rabia Gizem , Yildiz Faruk , Usta Ufuk , Kurultak Ilhan , Ustundag Sedat
Published: August 2019

Postinfectious glomerulonephritis (PIGN) is an immune-mediated glomerulonephritis caused by bacterial infections. Treatment of PIGN includes appropriate treatment of underlying infection and supportive treatment of the nephritic syndrome. Immunosuppressive drugs may be used to treat PIGN who have a renal failure with or without crescents and suggested only to the patients who does not have an active infection. We report a case who had PIGN secondary to a chronic foot infection and successfully treated with plasmapheresis for the first time in the literature.
Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model
Authors: Zhang Xiwen , Wang Weili , Ji Xin-Ying , Ritter Joseph K. , Li Ningjun
Published: August 2019

Background: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in various diseases. S1P also plays significant roles in the differentiation of fibroblasts into myofibroblasts, being implicated in fibrotic diseases. S1P is produced by the phosphorylation of sphingosine catalyzed by sphingosine kinases (SphK1 and SphK2). It remains unclear if the activation of endogenous SphK1 contributes to fibrogenesis in kidneys. The present study determined the effect of SphK1 gene knockout (KO) on fibrotic markers in kidneys. Methods: The renal fibrosis was produced using the unilateral ureteral obstruction (UUO) model in wild-type (WT) and SphK1 gene KO mice. Renal mRNA levels of SphK1 and S1P receptors (S1PR) were measured by real-time RT-PCR. Fibrotic and immune cell markers in kidneys were measured by Western blot analysis and immunostaining, respectively. Renal morphological damage was examined by Periodic-Acid Schiff staining. Results: The mRNA levels of SphK1 and S1PRs were dramatically increased in renal tissues of WT-UUO mice, whereas the increase in renal SphK1 mRNA was blocked in KO-UUO mice. Interestingly, the increased levels of fibrotic markers, collagen and α-smooth muscle actin, in kidneys were significantly attenuated in KO-UUO versus WT-UUO mice. Meanwhile, kidney damage indices were remarkably attenuated in KO-UUO mice compared with WT-UUO mice. However, increased numbers of CD43+ and CD48+ cells, markers for T cell and macrophage, respectively, showed no significant difference between ­WT-UUO and KO-UUO kidneys. Conclusion: The activation of the SphK1-S1P pathway may contribute to tubulointerstitial fibrosis in UUO kidneys by affecting fibrotic signaling within renal cells independent of immune modulation.
O museu como espaço de interação: arquitetura, museografia e museologia
Authors: Lupo Bianca Manzon
Published: August 2019

O conceito de interatividade tem sido amplamente utilizado como premissa para a estruturação institucional de museus, sendo comumente introduzido no espaço museológico nas décadas recentes. A museografia interativa frequentemente aparece como alternativa para a apresentação de acervos formados a partir de bancos de dados digitais, participando ativamente da constituição de museus encarados como centros de referências e da criação das narrativas museais. O artigo pretende analisar a interatividade entendida como diálogo entre arquitetura, museografia e museologia, investigando sua relação com a concepção e recepção do espaço expositivo contemporâneo. Para tanto, possui como foco principal a análise do contexto brasileiro a partir dos casos de referência selecionados: Museu do Futebol (São Paulo, 2008) e Museu do Amanhã (Rio de Janeiro, 2015). Com o estudo proposto, pretende-se aprofundar o entendimento sobre a consolidação do campo da museografia interativa no Brasil, verificando suas implicações para o projeto de arquitetura museal.
Políticas de aquisição de acervo: instrumentos de gestão e de memória institucional
Authors: Vieira Leonardo Da Silva
Published: August 2019

Este artigo trata da importância de documentos relativos à gestão de acervos museológicos, em especial acerca dos padrões e métodos de aquisição de acervo, para a racionalização e a memória das práticas institucionais. Também compartilhamos alguns dados obtidos durante a pesquisa de mestrado intitulada Apontamentos acerca da política de aquisição de acervo no Museu Paulista (1990-2015), defendida pelo autor deste artigo no Programa de Pós-graduação Interunidades em Museologia da Universidade de São Paulo.
Sex Differences in the Use of Statins in Community Practice
Authors: Nanna Michael G. , Wang Tracy Y. , Xiang Qun , Goldberg Anne C. , Robinson Jennifer G. , Roger Veronique L. , Virani Salim S. , Wilson Peter W.F. , Louie Michael J. , Koren Andrew , Li Zhuokai , Peterson Eric D. , Navar Ann Marie
Published: August 2019

Background:

Female patients have historically received less aggressive lipid management than male patients. Contemporary care patterns and the potential causes for these differences are unknown.

Methods and Results:

Examining the Patient and Provider Assessment of Lipid Management Registry—a nationwide registry of outpatients with or at risk for atherosclerotic cardiovascular disease—we compared the use of statin therapy, guideline-recommended statin dosing, and reasons for undertreatment. We specifically analyzed sex differences in statin treatment and guideline-recommended statin dosing using multivariable logistic regression. Among 5693 participants (43% women) eligible for 2013 American College of Cardiology/American Heart Association Cholesterol Guideline–recommended statin treatment, women were less likely than men to be prescribed any statin therapy (67.0% versus 78.4%;
P
<0.001) or to receive a statin at the guideline-recommended intensity (36.7% versus 45.2%;
P
<0.001). Women were more likely to report having previously never been offered statin therapy (18.6% versus 13.5%;
P
<0.001), declined statin therapy (3.6% versus 2.0%;
P
<0.001), or discontinued their statin (10.9% versus 6.1%;
P
<0.001). Women were also less likely than men to believe statins were safe (47.9% versus 55.2%;
P
<0.001) or effective (68.0% versus 73.2%;
P
<0.001) and more likely to report discontinuing their statin because of a side effect (7.9% versus 3.6%;
P
<0.001). Sex differences in both overall and guideline-recommended intensity statin use persisted after adjustment for demographics, socioeconomic factors, clinical characteristics, patient beliefs, and provider characteristics (adjusted odds ratio, 0.70; 95% CI, 0.61–0.81;
P
<0.001; and odds ratio, 0.82; 95% CI, 0.73–0.92;
P
<0.01, respectively). Sex differences were consistent across primary and secondary prevention indications for statin treatment.

Conclusions:

Women eligible for statin therapy were less likely than men to be treated with any statin or guideline-recommended statin intensity. A combination of women being offered statin therapy less frequently, while declining and discontinuing treatment more frequently, accounted for these sex differences in statin use.
Oscillatory Mechanisms of Preparing for Visual Distraction
Authors: de Vries Ingmar E. J. , Savran Ece , van Driel Joram , Olivers Christian N. L.
Published: August 2019

Evidence shows that observers preactivate a target representation in preparation of a visual selection task. In this study, we addressed the question if and how preparing to ignore an anticipated distractor differs from preparing for an anticipated target. We measured EEG while participants memorized a laterally presented color, which was cued to be either a target or a distractor in two subsequent visual search tasks. Decoding the location of items in the search display from EOG channels revealed that, initially, the anticipated distractor attracted attention and could only be ignored later during the trial. This suggests that distractors could not be suppressed in advance but were represented in an active, attention-guiding format. Consistent with this, lateralized posterior alpha power did not dissociate between target and distractor templates during the delay periods, suggesting similar encoding and maintenance. However, distractor preparation did lead to relatively enhanced nonlateralized posterior alpha power, which appeared to gate sensory processing at search display onset to prevent attentional capture in general. Finally, anticipating distractors also led to enhanced midfrontal theta power during the delay period, a signal that was predictive of how strongly both target and distractor were represented in the search display. Together, our results speak against a distractor-specific advance inhibitory template, thus contrary to the preactivation of specific target templates. Rather, we demonstrate a general selection suppression mechanism, which serves to prevent initial involuntary capture by anticipated distracting input.
What Is a Cognitive System? In Defense of the Conditional Probability of Co-contribution Account
Authors: Rupert Robert D.
Published: August 2019

A theory of cognitive systems individuation is presented and defended. The approach has some affinity with Leonard Talmy’s Overlapping Systems Model of Cognitive Organization, and the paper’s first section explores aspects of Talmy’s view that are shared by the view developed herein. According to the view on offer – the conditional probability of co-contribution account (cpc) – a cognitive system is a collection of mechanisms that contribute, in overlapping subsets, to a wide variety of forms of intelligent behavior. Central to this approach is the idea of an integrated system. A formal characterization of integration is laid out in the form of a conditional-probability based measure of the clustering of causal contributors to the production of intelligent behavior. I relate the view to the debate over extended and embodied cognition and respond to objections that have been raised in print by Andy Clark, Colin Klein, and Felipe de Brigard.
‘A Rough Trade’? Towards a More Sustainable Minerals Supply Chain
Authors: Dam-de Jong Daniëlla
Published: August 2019

Target 16.6 of the 2015 Sustainable Development Goals (sdgs) seeks to create ‘effective, accountable and transparent institutions at all levels’ for the purpose of achieving sustainable development. Nevertheless, the inherent vagueness of the notions of transparency and accountability poses difficulties for achieving the target. This is why this article examines how these notions have been conceptualized in international legal discourse and applied in practice. It does so within the context of the trade in natural resources that finance armed conflict, which is considered detrimental to the development opportunities of developing countries. The article examines how two of the most important initiatives in this field, namely the Kimberley Process for the Certification of Rough Diamonds and the oecd Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-affected and High-risk Areas, operationalize transparency and accountability. It posits that both initiatives fall short of establishing full accountability. However, notwithstanding their flaws and limitations, they make a valuable contribution to achieving target 16.6.
Clothing as Devotion in Contemporary Hinduism
Authors: Mohan Urmila
Published: August 2019

In Clothing as Devotion in Contemporary Hinduism, Urmila Mohan explores the materiality and visuality of cloth and clothing as devotional media in contemporary Hinduism. Drawing upon ethnographic research into the global missionizing group “International Society for Krishna Consciousness” (ISKCON), she studies translocal spaces of worship, service, education, and daily life in the group’s headquarters in Mayapur and other parts of India. Focusing on the actions and values of deity dressmaking, devotee clothing and paraphernalia, Mohan shows how activities, such as embroidery and chanting, can be understood as techniques of spirituality, reverence, allegiance—and she proposes the new term “efficacious intimacy” to help understand these complex processes. The monograph brings theoretical advances in Anglo-European material culture and material religion studies into a conversation with South Asian anthropology, sociology, art history, and religion. Ultimately, it demonstrates how embodied interactions as well as representations shape ISKCON’s practitioners as devout subjects, while connecting them with the divine and the wider community.
Euphorbia rimireptans (Euphorbiaceae, Articulofruticosae), a new species from the Skeleton Coast, Namibia

Authors: SWANEPOEL WESSEL , BECKER ROLF W. , MӦLLER ALMA , DE CAUWER VERA
Published: August 2019

Euphorbia rimireptans, here described as a new species, is known only from the northern part of the Skeleton Coast (part of the Namib Desert) in the Kaokoveld Centre of Endemism, northwestern Namibia. These perennial shrublets grow on rocky outcrops of latite under harsh desert conditions. Diagnostic characters for E. rimireptans include the procumbent, sometimes pendant habit, the soft, rubber-like terete or slightly tapering branches that are curved or ± straight, frequently orientated in the same direction from the base, and the glabrous or sparsely hairy capsule, which releases verrucose ovoid seeds. A comparison of some of the more prominent morphological features to differentiate between E. rimireptans and its possible nearest relative, E. giessii, is provided.
A new species of Polycarpaea (Caryophyllaceae) from India

Authors: GEETHAKUMARY M. P. , DEEPU S. , A. R. VIJI , PANDURANGAN A. G.
Published: August 2019

Polycarpaea rangaiahiana, a new species of Caryophyllaceae from the lateritic plains of Kannur District, Kerala, India is described and illustrated. P. rangaiahiana is morphologically similar to P. aurea from which differs in having ovate-lanceolate stipules with fimbriate margin and other floral characters. The name P. aurea is discussed from the nomenclatural point of view and a second-step typification was proposed.
First record of the invasive land flatworm Bipalium adventitium (Platyhelminthes, Geoplanidae) in Canada
Authors: JUSTINE JEAN-LOU , THÉRY THOMAS , GEY DELPHINE , WINSOR LEIGH
Published: August 2019

Specimens of Bipalium adventitium (Platyhelminthes, Geoplanidae) were found in Montréal, Québec, Canada. The specimens showed the typical colour pattern of the species and barcoding (Cytochrome Oxidase I) demonstrated near-identity with a sequence of the same species from the USA. This is the first record of the species in Canada.
A new species of Tychus Leach, 1817 from Lebanon (Coleoptera, Staphylinidae, Pselaphinae)
Authors: SABELLA GIORGIO , VIGLIANISI FABIO MASSIMO , D’URSO VERA
Published: August 2019

Tychus meggiolaroi sp. n. from Lebanon is described and illustrated. It belongs to the Tychus cilicicus species group (Sabella & Kurbatov 2002) and can be readily distinguished from related taxa by the different structure of the aedeagus and morphological features of antennae.
Eukoenenia ibitipoca: the first troglobitic Palpigradi (Arachnida) from a quartzitic cave
Authors: SOUZA MAYSA FERNANDA VILLELA REZENDE , FERREIRA RODRIGO LOPES
Published: August 2019

Although the arachnids of the order Palpigradi are very common in subterranean habitats, no species has yet been recorded from siliciclastic caves. During a survey of cave invertebrates conducted in quartizitic caves in southern Minas Gerais state (Brazil), the occurrence of a new troglobitic palpigrade was revealed. Accordingly, in this paper we describe Eukoenenia ibitipoca sp. nov. which is readily distinguished from most species of this genus by the presence of eight pairs of setae on propeltidium.
Revision of Tynacantha Dallas with description of two new species (Hemiptera: Heteroptera: Pentatomidae: Asopinae)
Authors: BRUGNERA RICARDO , CAMPOS LUIZ ALEXANDRE , GRAZIA JOCELIA
Published: August 2019

Here, Tynacantha Dallas is revised and two new species are described from Brazil: T. cuprea Brugnera & Grazia sp. nov. and T. umeridenigrata Brugnera & Grazia sp. nov. The type material is analyzed, figures, illustrations, a distributional map and a key to the species are provided. The color variation found in T. marginata is also discussed.
New and interesting species of sacculonotic Haplozetidae (Acari, Oribatida, Haplozetidae) from Indonesia
Authors: ERMILOV SERGEY G. , SANDMANN DOROTHEE , SCHEU STEFAN
Published: August 2019

Two new species of haplozetid oribatid mites (Oribatida, Haplozetidae) are described on the basis of adult specimens sampled from litter and soil in Sumatra, Indonesia: Haplozetes bayartogtokhi sp. nov. differs from Haplozetes biheterodactylus Ermilov & Tolstikov, 2015 by the presence of minute interlamellar setae, foveolate anterior part of the notogaster, five pairs of genital setae and the localization of adanal lyrifissures in preanal position; Magyaria leonilae sp. nov. differs from Magyaria annobonica Pérez-Íñigo, 1981 and Magyaria ornata Balogh, 1963 by the presence of bidactylous legs, pointed rostrum and reticulate prodorsum. The species Indoribates hauseri (Mahunka, 1997) comb. nov. (Haplozetidae) is recorded in Indonesia for the first time. A supplementary description for this species is given in detail on the basis of adult specimens from Indonesia and its main morphological traits are summarized. The taxonomic status of the genus Bolkiah Mahunka, 1997 is discussed, resulting in the following new taxonomic proposals: Indoribates (=Bolkiah syn. nov.).
On Neotropical crab spiders: description of a new species of Onocolus (Araneae: Thomisidae)
Authors: TEIXEIRA RENATO AUGUSTO , MACHADO MIGUEL
Published: August 2019

The systematics and taxonomy of Neotropical stephanopines have been extensively studied over the last years (Machado et al. 2015; Silva-Moreira & Machado 2016; Machado et al. 2017, 2018; Prado et al. 2018). According to Machado et al. (2017), the genera Epicadus Simon, Epicadinus Simon and Onocolus Simon form a clade of taxa with characteristic structure of the male genitalia, consisting of a long and filiform embolus, discoid tegulum and the canoe-shaped RTA fused at the basis with an acute and curved DTA. However, the better diagnostic characters are remarkable somatic features and the structure of the female genitalia. While Epicadus present large species with three or five stout opisthosomal projections, elevated thoracic portion, sometimes presenting a median spire (Machado et al. 2018), Epicadinus is composed of smaller spiders with just three pointed opisthosomal projections and the tegument covered by elongated needle-shaped setae, which give these spiders a spiny appearance (Prado et al. 2018). The species of Onocolus, on the other hand, can be recognized by the dorsoventrally compressed prosoma, pentagonal opisthosoma, female genitalia with coiled or S-shaped copulatory ducts and predominant green body coloration. The genus Onocolus has been revised by Lise (1981). Here, we describe O. ankeri sp. nov., a species from the Amazon Forest that is remarkable by its size and color (Fig. 1).
New Myxophagan water beetles from Madagascar (Coleoptera: Torridincolidae, Hydroscaphidae)
Authors: PERKINS PHILIP D. , BERGSTEN JOHANNES
Published: August 2019

Myxophagan water beetles from Madagascar are comprehensively revised. Holotypes of the two previously known species are re-described and illustrated. Six new species of Incoltorrida Steffan and one new species of Hydroscapha LeConte are described and illustrated. The larvae of Incoltorrida quintacostata are illustrated and discussed. The presence of peritrich ciliates of the genus Platycola Kent on specimens of Incoltorrida madagassica Steffan is discussed and illustrated. Habitus, habitats, and male genitalia are illustrated, and distributions are mapped. The following new species are described (type localities parenthetic): Incoltorrida benesculpta n. sp. (Fianarantsoa, 3.2km S Ambohimanjaka); I. galoko n. sp. (Antsiranana, Diana, Ambilobe, Antsaba, Galoko mountains ); I. magna n. sp. (Antsiranana, Diana, Ambilobe, Antsaba, Galoko mountains); I. marojejy n. sp. (Antsiranana, Sava, Marojejy National Park); I. quintacostata n. sp. (Fianarantsoa, 3.5km N Ivato); I. zahamena n. sp. (Toamasina, Alaotra-Mangoro, Zahamena National Park); Hydroscapha andringitra n. sp. (Fianarantsoa, Ambilavao, Sendrisoa, approx. 10km N of Andringitra National Park).
Trust and Distrust of Automated Parking in a Tesla Model X
Authors: Tenhundfeld Nathan L. , de Visser Ewart J. , Ries Anthony J. , Finomore Victor S. , Tossell Chad C.
Published: August 2019

Objective

The present study aims to evaluate driver intervention behaviors during a partially automated parking task.

Background

Cars with partially automated parking features are becoming widely available. Although recent research explores the use of automation features in partially automated cars, none have focused on partially automated parking. Recent incidents and research have demonstrated that drivers sometimes use partially automated features in unexpected, inefficient, and harmful ways.

Method

Participants completed a series of partially automated parking trials with a Tesla Model X and their behavioral interventions were recorded. Participants also completed a risk-taking behavior test and a post-experiment questionnaire that included questions about trust in the system, likelihood of using the Autopark feature, and preference for either the partially automated parking feature or self-parking.

Results

Initial intervention rates were over 50%, but declined steeply in later trials. Responses to open-ended questions revealed that once participants understood what the system was doing, they were much more likely to trust it. Trust in the partially automated parking feature was predicted by a model including risk-taking behaviors, self-confidence, self-reported number of errors committed by the Tesla, and the proportion of trials in which the driver intervened.

Conclusion

Using partially automated parking with little knowledge of its workings can lead to high degree of initial distrust. Repeated exposure of partially automated features to drivers can greatly increase their use.

Application

Short tutorials and brief explanations of the workings of partially automated features may greatly improve trust in the system when drivers are first introduced to partially automated systems.
Consensus and dissensus in comparative politics: Do comparativists agree on the goals, methods, and results of the field?
Authors: Roberts Andrew
Published: August 2019

Are comparative political scientists divided over the goals, methods, and results of their field? This article attempts to answer this question, drawing on an original survey of US-based political scientists. The main conclusion is that there is relative consensus on the goals of research—comparativists favor broad generalizations and causal inference—but there is also acceptance of a variety of methodological approaches, both qualitative and quantitative, in pursuing this goal. Comparativists, however, show less agreement on substantive findings in the areas of democracy and democratic politics, economy and society, and political institutions. Interestingly, generational differences are relatively infrequent, but gender differences on issues such as rational choice and causal inference are more prominent, possibly contributing to gendered citation bias. The findings suggest that comparative politics may not have accumulated a large amount of agreed-upon knowledge, but that there is substantial agreement on the path forward.
Linguistic Crisis Prediction: An Integration of the Linguistic Category Model in Crisis Communication
Authors: Borden Jonathan , Zhang Xiaochen Angela
Published: August 2019

Through two experiments, this study examines the relationship between linguistic choice and attribution perception in organizational crisis. Experiment 1 demonstrated that abstract (vs. concrete) language in crisis news elicited higher attribution and lower purchase intentions. Experiment two showed that preventable (vs. victim) crisis led to higher usage of abstract language in describing and commenting on the crisis. Also, abstract language use in describing and commenting on the crisis mediates crisis clusters’ effect on purchase intentions. Furthermore, attribution of crisis responsibility mediated crisis cluster and in-group/out-group’s effects on abstract language use in describing and commenting on the crisis. The findings empirically connect two attribution theory-rooted theories: linguistic category model and the situational crisis communication theory.
Religion and Support for Political Violence among Christians and Muslims in Africa
Authors: Adamczyk Amy , LaFree Gary
Published: August 2019

Researchers have found consistently that religion reduces criminal behavior. Yet rising levels of political violence are frequently attributed to a new wave of religious terrorism. Our study seeks to reconcile this apparent discrepancy by studying the attitudes of people living in 34 African nations. Using data from the Afrobarometer survey and mixed modeling, we examine the influence of individual and collective religiosity for shaping civic engagement and willingness to engage in political violence. While individual religiosity decreases support for violent political action, collective religiosity increases it. The effects of religiosity are the same for Muslims and Christians and the country religious context minimally affects residents’ civic engagement and interest in violent political behavior. Our study underscores the importance of the theoretical and empirical distinction between individual and collective religiosity and offers insight into how civic engagement can be a pathway through which religion shapes support for political violence.
FASim: A 3D Serious Game for the First Aid Emergency
Authors: Benkhedda Samira , Bendella Fatima
Published: August 2019

Background and Aim. This article aims to present FASim (First Aid Simulator), a 3D serious game for the first aid emergency. This game combines in a single framework the healthcare simulations with serious games and the functionalities of the multi agents systems (MAS). This work devoted to the basic steps in the development of our serious game FASim to learn the first aids and the signs of cardiac arrests which are the leading cause of premature death and the major cause of disability in the world.

The practice of serious games in healthcare should be based on four main axes; firstly, the interaction between players is the key element of learning; secondly the adaptation of the game to the profiles of the players. So the game must be in relation with their abilities. Thirdly, the awareness and prevention are the important ingredients in healthcare to promoting the collective recognition of problems of giving the first step towards its resolution; finally, we need some intelligence to organize the first three axes to be able to make quick and accurate decisions.

Results and Conclusion. The speed of intervention in the case of rapid cardiopulmonary resuscitation (CPR) increases the probability of survival after sudden cardiac arrest is still the key element to ensure success proven by QRISK method, which is a mathematical application to calculate the probability of having a heart attack. The number of staff must be very high preferences as a result we have created the collaboration to save the maximum life possible, and we implement an adaptive approach to improve the usability of the game. FASim focuses on the action of making quick and precise decisions, which must require a practical reasoning provided by the integration of the BDI (Belief Desire Intention) agent in the Non Players Character (NPCs). All our solutions are focus on the agent-based simulation, which is an excellent approach answer to all the criteria of medical emergencies.
Survey on Barriers to Critical Care and Palliative Care Integration
Authors: Kyeremanteng Kwadwo , Beckerleg Weiwei , Wan Cynthia , Vanderspank-Wright Brandi , D’Egidio Gianni , Sutherland Stephanie , Hartwick Michael , Gratton Valérie , Sarti Aimee J.
Published: August 2019

Purpose:

It has been shown that integrating palliative care (PC) in intensive care unit (ICU) improves end-of-life care (EOLC), but very few Canadian hospitals have adopted this practice. Our study aims to evaluate the perceived quality of EOLC at participating institutions and explore barriers toward ICU-PC integration.

Materials and Methods:

A self-administered questionnaire was developed by a multidisciplinary team. Survey items were extracted from published quality indicators in EOLC and barriers to ICU-PC integration. The study took place at 2 academic institutions. Participants consisted of physicians and nurses, ICU administrators, and allied health workers.

Results:

An overall response of 45% was achieved. Of total, 85% of the respondents were ICU nurses. The following main themes were identified: (1) There is a poor presence of PC in the ICU and 78% of respondents felt that increasing ICU-PC integration will improve quality of EOLC; (2) the main barrier to integration was unrealistic patient and/or family expectations; and (3) criteria-triggered consultation to PC was the most feasible way to achieve integration.

Conclusion:

Our findings indicate that the majority of respondents perceive that the presence of PC in ICU will improve EOLC. Future quality improvement initiatives can focus on developing a set of criteria for triggering PC consults.
Getting Off the List: Leadership, Learning, and Context in Two Rural, High-Needs Schools
Authors: Klar Hans W. , Moyi Peter , Ylimaki Rose M. , Hardie Suzy , Andreoli Parker M. , Dou Jingtong , Harrington Keneisha , Roper Cindy , Buskey Frederick C.
Published: August 2019

In this article, we report findings from two cases of rural, high-needs elementary schools in the Southeastern United States that successfully improved learning outcomes for their students. As illustrated by our findings, a combination of effective teacher professional development, focused student learning initiatives, and enhanced community and family involvement contributed to the removal of the schools from priority and below average designations. In addition to illustrating the leadership practices that positively influenced improvement efforts in these two schools, and expanding the nascent body of scholarship on context-responsive leadership, our findings serve as a starting point for a larger project centered on the nexus of school leader agency in increasingly diverse cultural contexts.
Gender Bias Still Plagues the Workplace: Looking at Derailment Risk and Performance With Self–Other Ratings
Authors: Braddy Phillip W. , Sturm Rachel E. , Atwater Leanne , Taylor Scott N. , McKee Rob Austin
Published: August 2019

Whereas overt forms of discrimination against women at work have decreased over time with the passage of formal antidiscrimination laws, implicit biases against women still plague organizations. To understand how implicit biases may appear in the workplace today, we examined how dissimilar outcomes may emerge for men and women leaders when their self-ratings differ from others’ (e.g., subordinates, peers) ratings. Drawing upon role congruity theory of prejudice toward female leaders and the status incongruity hypothesis, we theorized and found that women who overrated their leadership behaviors received lower performance ratings and higher perceived risk of derailment scores from their supervisors than did women who underrated their leadership behaviors. Men, however, experienced fewer negative consequences (than women) when they overrated. Given these findings, especially in light of discovering that most self–other agreement (SOA) research does not explicitly address gender as a main variable of interest, we question some of the field’s previous findings. We discuss the implications of our results for both practice and research regarding how SOA plays a role in the development of one’s career, highlighting the potential importance of implicit gender biases.
Comparison of Rural Childhood BMI Percentiles: Prevalence and Trends in a Midwest County, 2008–2016
Authors: Reilly Janet , Zhu Le , Hunt Megan J. Olson , Hovarter Rebecca , Flood M. Brigid
Published: August 2019

The number of children who are obese and overweight continues as a public health challenge despite decades of research. The purpose of this article is to describe trends in body mass index (BMI) percentile data collected from 11- to 14-year-old school children in 2008–2009 and 2015–2016 in rural Wisconsin. The BMI percentiles from 1,347 students were compared using time, gender, age, and school (public vs. parochial) as predictors. The trend over time indicated a decrease in students of healthy weight and an increase in those overweight or obese. Also noted was a significantly higher proportion of children who were overweight or obese in parochial compared to public schools. Discussed are the observed trends, community-wide initiatives implemented, as well as how schools can employ a more comprehensive approach to childhood obesity that first ensures community readiness and involves school, home, and community.
A Test of the Career Construction Theory Model of Adaptation in Adult Workers With Chiari Malformation
Authors: Tokar David M. , Savickas Mark L. , Kaut Kevin P.
Published: August 2019

The present study examined the career construction theory (CCT) model of adaptation using a sample of working adults diagnosed with Chiari malformation. Specifically, we tested a mediation model in which adaptivity (i.e., proactivity, openness, and conscientiousness) fosters adaptability, which conditions adapting (i.e., competence need satisfaction at work), which leads to adaptation (i.e., work well-being and subjective well-being). Results of structural equation modeling supported all of the hypothesized direct and indirect relations between CCT constructs, thus providing strong support for the applicability of the model of adaptation among workers with Chiari malformation. Prior to testing the model of adaptation, we examined and found support for the hypothesized hierarchical structure of the Career Adapt-Abilities Scale–Short Form, a recently developed operationalization of career adaptability.
Integrating the Washington Media Scholars Case Study Competition into a Capstone Course
Authors: Hendricks Beth R.
Published: August 2019

Integrating the WMSF Case Study competition into a capstone course will create a whole new dynamic for students. The case studies provided by WMSF are valuable for students because they demonstrate that strategically selecting a target and creating a media mix that will communicate to the chosen target sometimes requires a flexible, human brain processing the information into the best possible choices. The case studies are more than media choices. They are actual problems or opportunities based in the domain of nonpartisan political communication that require students to delve into the organizations or individuals involved and utilize media to communicate messages. Many students want to just look at the given budget and divide it up equally, but I encourage the students to read the case study over several times to catch the nuances in the case.
Top-Down and Intact Protein Mass Spectrometry Data Visualization for Proteoform Analysis Using VisioProt-MS
Authors: Lesne Jean , Bousquet Marie-Pierre , Marcoux Julien , Locard-Paulet Marie
Published: August 2019

The rise of intact protein analysis by mass spectrometry (MS) was accompanied by an increasing need for flexible tools allowing data visualization and analysis. These include inspection of the deconvoluted molecular weights of the proteoforms eluted alongside liquid chromatography (LC) through their representation in three-dimensional (3D) liquid chromatography coupled to mass spectrometry (LC-MS) maps (plots of deconvoluted molecular weights, retention times, and intensity of the MS signal). With this aim, we developed a free and open-source web application named VisioProt-MS ( https://masstools.ipbs.fr/mstools/visioprot-ms/ ). VisioProt-MS is highly compatible with many algorithms and software developed by the community to integrate and deconvolute top-down and intact protein MS data. Its dynamic and user-friendly features greatly facilitate analysis through several graphical representations dedicated to MS and tandem mass spectrometry (MS/MS) analysis of proteoforms in complex samples. Here, we will illustrate the importance of LC-MS map visualization to optimize top-down acquisition/search parameters and analyze intact protein MS data. We will go through the main features of VisioProt-MS using the human proteasomal 20S core particle as a user-case.
A multicultural success story? Australian integration in comparative focus
Authors: Busbridge Rachel
Published: August 2019

Australia is often held up as an exemplary multicultural society in cross-national comparisons, particularly in relation to the integration of immigrants. Yet, this ‘grand narrative’ of Australia’s multicultural success risks an over-simplified picture of the dynamics of integration in Australia, obscuring dimensions on which Australia’s performance is comparatively poor. Juliet Pietsch’s Race, Ethnicity and the Participation Gap makes a valuable contribution to a more nuanced discussion, asking why the political participation of non-European ethnic and immigrant minorities in Australia is so low compared to Canada and the United States. This review article brings Pietsch into critical conversation with two recent books on comparative integration in North America and Western Europe: Richard Alba and Nancy Foner’s S trangers No More and Gulay Ugur Goksel’s Integration of Immigrants and the Theory of Recognition. Read alongside each other, these texts encourage deeper reflection on where Australia sits on a variety of indicators of immigrant integration as well as how integration is conceptualised in Australia. This article thus contributes to existing literature on the contemporary state of Australian multiculturalism, while also pointing towards directions for future research.
Perceiving education from Facebook profile pictures
Authors: Reiss Michael V. , Tsvetkova Milena
Published: August 2019

Our upbringing and education influence not only how we present and distinguish ourselves in the social world but also how we perceive others. We apply this central sociological idea to the social media context. We conduct a large-scale online study to investigate whether observers can correctly guess the education of others from their Facebook profile pictures. Using the binomial test and cross-classified mixed-effects models, we show that observers can assess the education of depicted persons better than chance, especially when they share the same educational background and have experience with the social media. We also find that posting pictures of outdoor activities is a strong signal of having higher education, while professional photographs can obscure education signals. The findings expand our knowledge of social interaction and self-expression online and offer new insights for understanding social influence on social media.
Anchors for deliberation and shared deliberation: Understanding planning in young adults transitioning from out-of-home care
Authors: Appleton Peter
Published: August 2019

This theoretical paper focuses on early-stage planning in young adults in transition from out-of-home care. The theoretical approach builds on philosophical accounts of planning and shared planning by Michael Bratman and Jennifer Morton; previous research on care leavers’ experience; and findings from two recent qualitative studies of planning in care leavers in the UK. There are three central proposals of the paper. First, that if we focus on a young person’s deliberations about what matters (‘anchors for deliberation’), or what is important – to her or him – we may better understand the early stages of planning. Second, that social-cooperative or shared deliberations may be of special importance in understanding and supporting the early stages of planning in young people leaving care, partly because of the severe disruptions to social relationships that may have afflicted many care leavers during their earlier development. Third, that it may also be important to understand young people’s standpoints on planning norms, in both individual and social-cooperative contexts, given some young people’s subjection to repeated violation of norms. After introducing Bratman’s and Morton’s work, we suggest three categories of early-stage planning: specific anchors, policy-based anchors (including self-reliance, and ‘I don’t plan’), and anchors for the provisional future. Implications of the theoretical approach for research and practice are outlined. The paper aims to contribute to a theoretical basis for collaborative transition-planning (or ‘pathway planning’ in the UK) with young adults leaving care.
Cognitive Training in Young Patients With Traumatic Brain Injury: A Fixel-Based Analysis
Authors: Verhelst Helena , Giraldo Diana , Vander Linden Catharine , Vingerhoets Guy , Jeurissen Ben , Caeyenberghs Karen
Published: August 2019

Background. Traumatic brain injury (TBI) is associated with altered white matter organization and impaired cognitive functioning. Objective. We aimed to investigate changes in white matter and cognitive functioning following computerized cognitive training. Methods. Sixteen adolescents with moderate-to-severe TBI (age 15.6 ± 1.8 years, 1.2-4.6 years postinjury) completed the 8-week BrainGames program and diffusion weighted imaging (DWI) and cognitive assessment at time point 1 (before training) and time point 2 (after training). Sixteen healthy controls (HC) (age 15.6 ± 1.8 years) completed DWI assessment at time point 1 and cognitive assessment at time point 1 and 2. Fixel-based analyses were used to examine fractional anisotropy (FA), mean diffusivity (MD), and fiber cross-section (FC) on a whole brain level and in tracts of interest. Results. Patients with TBI showed cognitive impairments and extensive areas with decreased FA and increased MD together with an increase in FC in the body of the corpus callosum and left superior longitudinal fasciculus (SLF) at time point 1. Patients improved significantly on the inhibition measure at time point 2, whereas the HC group remained unchanged. No training-induced changes were observed on the group level in diffusion metrics. Exploratory correlations were found between improvements on verbal working memory and reduced MD of the left SLF and between increased performance on an information processing speed task and increased FA of the right precentral gyrus. Conclusions. Results are indicative of positive effects of BrainGames on cognitive functioning and provide preliminary evidence for neuroplasticity associated with cognitive improvements following cognitive intervention in TBI.
Impact of deep brain stimulation on people with Parkinson’s disease: A mixed methods feasibility study exploring lifespace and community outcomes
Authors: Liddle Jacki , Sundraraj Amreetaa , Ireland David , Bennett Sally , Stillerova Tereza , Silburn Peter
Published: August 2019

Background

Deep brain stimulation is a surgical treatment for Parkinson’s disease. Its impacts on motor symptoms are widely reported; however, little is known about the broader impact of deep brain stimulation on the community lives of people with Parkinson’s disease. Lifespace is a measure of lived community mobility, providing an indication of community access and participation.

Aims

This pilot study explored the feasibility of remotely monitoring the qualitative and quantitative community outcomes related to deep brain stimulation.

Methods

A longitudinal mixed methods study with a convergent design was undertaken exploring the lifespace, quality of life, life satisfaction and lived experiences of people with Parkinson’s disease before and after deep brain stimulation. Data were collected through questionnaires, semi-structured interviews and a smartphone-based application which collected geolocation data.

Results

Quantitative and qualitative data from eight participants living with Parkinson’s disease were analysed and integrated. At baseline, participants had a median age of 68 years and a median Hoehn and Yahr score of 2. Measuring a range of community-based outcomes indicated different change trajectories for individuals across outcomes. Key content areas were developed from the qualitative data: participation in occupations and travel and home. This study indicates the potential value of including geolocation data-based lifespace collection in metropolitan and regional areas.

Conclusions

Monitoring lifespace in conjunction with subjective measures provides insights into the complex and individually varied experiences. Further research could explore the impacts of deep brain stimulation on occupations and community participation to gain a deeper understanding of the related needs and support clinical approaches.
One-pot synthesis of novel N,N-bis(isoxazol-5-yl)methyl tertiary arylamines via sequential diprop-3-ynylation and 1,3-dipolar cycloaddition from primary amines
Authors: Zhang Xiao-Lan , Wei Mei-Hong , Sheng Shou-Ri , Liu Xiao-Ling
Published: August 2019

A simple and efficient one-pot multicomponent approach for the synthesis of tertiary arylamines bearing N,N-bis(isoxazol-5-yl)methyl groups is developed through reactions including sequential diprop-3-ynylation of primary amines with propargyl bromide in the presence of calcium hydride in N,N-dimethylformamide, and 1,3-dipolar cycloaddition with nitrile oxides generated in situ from hydroximyl chlorides in DMF-Et3N. This protocol provides advantages such as high regioselectivity, easy operation, and moderate-to-good product yields with a wide substrate scope under mild conditions.