bluuebunny/crossref_metadata_2025 huggingface dataset:
Evliya Çelebi Seyahatnamesi’nde Şekerin Serüveni
Authors: Keikha Shahinpour Gülistan
Published: November 2024

Ünlü Osmanlı seyyahı Evliya Çelebi’nin (d. 1611-ö. 1685) gözlemlerine dayanan bu çalışmada, Anadolu ve Akdeniz kıyılarında şeker kamışının yetiştirildiği yerler, lüks bir meta olan şekerin kullanıldığı tatlılar ve şekerle ilgili esnaflar ele alınmaktadır. Şekerin önemi 17. yüzyıldan önce de pahalı ve sosyo-ekonomik hayatı etkileyen bir ürün olmasından kaynaklanmaktadır. Şekerin mutfakta ve toplumsal yaşantıda nasıl bir rol oynadığı vurgulanmaktadır. Yiyecek-içecek kültürünün yanı sıra sosyal statü ve güç göstergesi olarak görülen şeker hediye olarak da verilmekteydi. Bunun yanı sıra 17. yüzyılda Mısır’da kullanılan şeker değirmenlerine rastlanmaktadır. Ayrıca Mısır’da şekerin tarihinin milattan sonra 7. yüzyıldan öncesine tarihlenebileceği ileri sürülmektedir. Nitekim bu değerlendirmeyle literatüre bir katkı sağlamak amaçlanmaktadır. Şekerle ilgili bilgilere dayanarak sosyal hayata dair genel bir çerçeve çizilmektedir. Veriler, içerik analiziyle değerlendirilmektedir ve literatürle desteklenmektedir.
Analytical statistics of scientific publications on Scilit (using the example of Keldysh Institute publications)
Authors: Ermakov Alexey Viktorovitch
Published: November 2024

The paper addresses issues related to the creation of data archives, their publication, placement of metadata in the Crossref bibliographic database and citation of datasets in scientific publications. Examples of popular world data archives are given and an experiment on creating and publishing datasets in KIAM is described.
CONTEMPORARY TRENDS IN CERAMIC PRODUCTION: CREATION OF ALUMINOSILICATE PRODUCTS USING 3D PRINTING AND THE IMPACT OF INNOVATIVE APPROACHES ON THE INDUSTRY
Authors: Kryvobok Ruslan , Riabinin Oleksandr , Ryshchenko Oleksandr , Lebedev Vladimir , Voronkin Andrii
Published: November 2024

The article discusses modern trends in the production of ceramics in the creation of aluminosilicate ceramic products using 3D printing or additive manufacturing. Ceramic is a high-performance material because it has hard, mechanically strong properties, excellent wear resistance, and high temperature and corrosion resistance. Traditional methods of ceramic production are also considered, which consist of three stages: material preparation, molding (can be performed using various methods, such as isostatic pressing, pressure pressing, pressure casting, tape casting, gel casting, suspension casting, etc. ) and sintering. 3D printing technology is an effective and promising production method that continues to develop and find new applications in various fields: medical, chemical, biochemical, environmental, technical, radio engineering, etc. New research and development allow to improve the quality and accuracy of printing, as well as to expand the possibilities of using ceramic materials. Special importance is given to the advantages of using 3D printing for the manufacture of ceramic products, in particular, the ability to create an individual product design and achieve the desired shape, composition, microstructure and properties. The use of 3D printing technology also helps to reduce waste and lower material costs, making the production process more environmentally friendly and cost-effective. In general, the article provides information about current directions in the production of ceramics and the impact of innovative methods on this branch of industry. The advantages and prospects of using 3D printing to create ceramic products are analyzed, and an overview of the materials and methods used in this process is provided. In addition, the article discusses the materials used in 3D printing technology, which can be classified depending on their suitability for the chosen manufacturing method or by the type of material.
FEATURES OF CYCLE OPENING IN THE gem-DIHALOGENCYCLOPROPYL DERIVATIVES OF THIOANISOLE IN THE SYSTEM CuSO4/DMSO/H2O
Authors: Mikhedkina Olena , Tsygankov Alexandr , Larina Hanna
Published: November 2024

The results of studies on the cleavage of the cyclopropane ring in 2,2-dichloro- and 2,2-dibromocyclopropylmethyl(phenyl)sulfides under the action of copper sulfate in aqueous dimethylformamide are presented. It is shown that under these conditions, when heated at 100-105 °C for 10-11 hours, mixtures of three isomeric chloro(bromo)-allyl alcohols are formed. The ratios of these alcohols were determined by comparing the integral intensities of the proton signals in the 1H NMR spectra and the integral intensities of the chromatograms and are approximately 3.54:3.15:1 for dichloro- and 5.1:3.9:1 for dibromocyclopropyl derivatives. The structure of the isomeric alcohols was proved by the results of NMR 1H analysis and fragmentation in the mass spectra.
Under the same conditions, the action of Cu(II)+ ion on the oxidation products of 2,2-dichloro- and 2,2-dibromocyclopropylmethylphenylsulfonyl sulfides did not show ring cleavage according to thin layer chromatography. When the temperature reaches above 150 °C, the corresponding sulfones are charred.
The influence of the nature of the halogen on the regioselectivity of the reaction was analyzed. A likely reaction mechanism involves the formation of an allylic cation as a key intermediate. The obtained results expand the understanding of the reactivity of heme-dihalogencyclopropanes and open new perspectives for the synthesis of functionalized organic compounds, in particular, potential biologically active ones. It was found that replacing the phenylthio substituent with a phenylsulfonyl one significantly reduces the reactivity of the cyclopropane ring.
RECYCLING OF DOMESTIC AND INDUSTRIAL WASTEWATER USING VERMIFILTRATION TECHNOLOGY
Authors: Zinchenko Mariya , Bukatenko Nataliia , Misyk Yaryna
Published: November 2024

One of the biggest problems of our time is the growing shortage of fresh water. According to the World Health Organization, by the middle of the 21st century, half of the planet's inhabitants will experience an acute shortage of fresh water. Simultaneously with the growing consumption of clean water, the annual volume of wastewater from municipal, agricultural and industrial enterprises also increases. At the same time, the volume of water used annually is more than an order of magnitude higher than the volume of treated wastewater. Untreated wastewater is characterized by a high content of organic impurities and pathogenic microorganisms capable of causing diseases that are dangerous for human life. In connection with the outlined extremely urgent task is to ensure effective purification of wastewater from pollution with subsequent recycling of purified effluents - their reuse for other purposes: in the circulating system of industrial enterprises, agricultural and landscape irrigation systems. From this point of view, the process of vermifiltration - wastewater treatment using earthworms - is of great interest. The technology is based on the ability of worms to work as "biofilters". Worms absorb organic and inorganic pollutants from wastewater, digest them and release them in the form of their excrement (coprolites) into the environment. With such processing, wastewater is cleaned, disinfected, and detoxified; treated effluents are suitable for reuse. There is also a transformation of organic and inorganic components into organo-mineral fertilizer - vermicompost and biomass of earthworms, which can serve as raw materials for the fodder and pharmaceutical industry.
RESEARCH AND ANALYSIS OF THE FEATURES OF MATHEMATICAL MODELS OF MODERN SOCIAL RELATIONS
Authors: Iglin Sergii
Published: November 2024

Modern approaches to the study of mathematical modeling methods make it possible to consider society as a complex system andto apply methods tested primarily in the varieties of the development of scientific fields. It should be noted that approaches that arebased on the application of exact methods and mathematical formalism, for example, simulation modeling, in fact, can give mostlyqualitative conclusions, which is due to the multi-parameter nature of socio-legal models. An analysis of the state of modeling inthe social and legal spheres shows that it is entering a stage of growth throughout the world. The understanding of the importance ofthis direction is growing both on the part of the scientific community and on the part of practical sociology, jurisprudence andeconomics. A community of people with relationships between them is modeled as a directed graph with weighted vertices andarcs. There are groups of mutual influence, leaders, outsiders, the degrees of influence of some people on others are calculated.
DESIGNING EQUIPMENT FOR SYNERGETIC CHEMICAL ENGINEERING PROCESSES ACCORDING TO DRILLING RIG MODERNIZATION RESEARCH MODELS
Authors: Bukhkalo Svetlana , Savyk Vasyl , Boyko Vladyslav , Aheicheva Oleksandra
Published: November 2024

In the materials of the article, examples of calculations and selection of a technological complex for drilling a well with a depth of 5650 m are considered, a complex of mechanization and partial automation of lowering and lifting operations during well drilling is analyzed, the advantages of such systems are established compared to installations that are not equipped with a complex of ASP mechanisms. The justification of the feasibility and economic efficiency of the introduction of the proposed technical solutions for the development of a device for limiting the movement of the melting unit of the drilling rig was carried out, its principle and electrical diagrams were proposed, the technical feasibility was substantiated, and the economic effect of the implementation of the developed design of the device for limiting the movement of the melting unit was calculated. The components of the developed methodology for calculating energy costs and machine time costs during SPO by lifting complexes are presented, an assessment of the perfection of lifting complexes of drilling rigs with different drives in terms of machine time costs of lifting a drill string for a well drilling cycle, an assessment of the perfection of lifting complexes of drilling rigs with different drives in terms of energy consumption rise of the drill string during the well drilling cycle. The materials of the article consider examples the calculation and the chosen technological complex for wells drilling with the depth of 5650 m, analyses the complex of mechanisms to mechanise and partially automate lowering-lifting operations while wells drilling and establishes advantages of such systems, comparing to the sets not equipped with the complex of mechanisms ALL.
Pengembangan Game Edukasi Berbasis Android Bermuatan Profil Pelajar Pancasila pada Materi Penempatan Bilangan
Authors: Mubarok Bayu , Ningsih Puji Rahayu
Published: November 2024

Penelitian ini bertujuan untuk mengetahui alur atau cara mengembangkan Game Edukasi berbasis Android berbermuatan profil pelajar pancasila pada materi penempatan bilangan siswa kelas II di SDIT ULIL ALBAB Kamal. Penelitian ini menggunakan model ADDIE (Analysis, Design, Development, Implementation, dan Evaluation). Penelitian menggunakan instrument penilaian angket ahli materi, ahli media dan uji coba sasaran berupa uji coba perorangan, kelompok kecil dan kelompok besar. Hasil validasi ahli materi 1 mendapatkan presentase sebesar 84% dengan kategori sangat layak. Hasil validasi ahli materi 2 mendapatkan presentase sebesar 85% dengan kategori sangat layak. Hasil validasi ahli media 1 mendapatkan presentase sebesar 99% dengan kategori sangat layak. Hasil validasi ahli media 2 mendapatkan presentase sebesar 89% dengan kategori sangat layak. Uji coba perorangan dilakukan oleh 2 peserta didik dengan mendapatkan hasil presentase sebesar 91% dengan kategori sangat layak. Uji coba kelompok kecil dilakukan oleh 5 peserta didik dengan mendapatkan hasil presentase sebesar 92% dengan kategori sangat layak. Uji coba kelompok besar dilakukan oleh 15 peserta didik dengan mendapatkan hasil presentase sebesar 93% dengan kategori sangat layak. Berdasarkan data yang diperoleh maka Pengembangan Game Edukasi Berbasis Android Bermuatan Profil Pelajar Pancasila Pada Materi Penempatan Bilangan layak digunakan dalam proses pembelajaran.
Implementasi Intelligence Auto Find System dalam Pemetaan Objek Parawisata Di Pulau Madura Berbasis Website
Authors: Tahir Muhlis , Effindi Muhamad Afif
Published: November 2024

Pulau Madura yang terletak di sebelah timur laut Provinsi Jawa Timur memiliki potensi wisata alam yang eksotis namun kurang dikenal oleh masyarakat luas. Upaya meningkatkan pemahaman dan promosi objek wisata di Pulau Madura, dibutuhkan sebuah aplikasi berbasis web yang dapat menyajikan informasi secara efisien. Penelitian ini bertujuan untuk merancang dan mengimplementasikan sebuah website pariwisata Pulau Madura dengan menggunakan metode Intelligence Auto Find System (IAFS), sebagai alat pencarian informasi berbasis kata kunci. Metode yang digunakan dalam penelitian ini adalah Rapid Application Development (RAD) yang terdiri dari tiga tahap, yaitu analisis persyaratan, desain sistem, dan konstruksi sistem. Hasil penelitian menunjukkan bahwa website yang dirancang dapat menyediakan informasi wisata dengan menggunakan konsep multimedia, termasuk gambar, teks, dan deskripsi tempat wisata yang menarik di Pulau Madura. Hasil uji coba sistem dengan menggunakan instrumen yang disebarkan kepada 25 pengguna di SMK PGRI 1 Bangkalan menunjukkan bahwa website ini layak digunakan dengan respons yang sangat baik dari pengguna. Website ini dapat memenuhi kebutuhan pengguna dalam mencari informasi wisata, serta menjadi media promosi yang efektif untuk meningkatkan kunjungan wisatawan ke Pulau Madura. Kesimpulannya, sistem yang dikembangkan telah berhasil mempromosikan destinasi wisata Madura dengan baik dan dapat digunakan sebagai solusi untuk memperkenalkan potensi pariwisata di wilayah tersebut.
Pengembangan E-Learning Sistem Komputer Kelas X di SMKN 1 Kwanyar
Authors: Stefany Evy Maya , Dellia Prita , Khoiroh Merry Dian
Published: November 2024

Penelitian ini bertujuan untuk mengetahui kelayakan, kepraktisan dan efektivitas e-learning berbasis website pada materi sistem komputer. Penelitian ini menggunakan metodologi penelitian Research and Development (RD) dengan model pengembangan 4D (Define, Design, Development, Disseminate). Instrumen yang digunakan adalah angket validasi dan angket respon siswa. Hasil penelitian menunjukkan bahwa sistem e-learning komputer berbasis website ini efektif dari segi materi, bahasa, dan desain. Selain itu, media tersebut juga dinilai praktis dan efektif bagi siswa. Penelitian ini melibatkan siswa kelas X SMKN 1 Kwanyar. Data tentang sumber belajar siswa diperoleh dengan menggunakan metode wawancara. Selanjutnya produk diujicobakan kepada siswa melalui tiga tahap, yaitu uji coba perorangan, uji coba kelompok kecil, dan uji coba lapangan. Subyek uji coba penelitian ini terdiri dari 3 siswa untuk uji coba perorangan, 12 siswa untuk uji coba kelompok kecil, dan 35 siswa untuk uji coba lapangan. Data yang dikumpulkan dalam penelitian ini adalah data dari uji ahli materi, uji ahli desain, uji ahli media pembelajaran, dan dari uji coba siswa. Pengembangan e-learning sistem komputer kelas X di SMKN 1 Kwanyar menunjukkan bahwa hasil penelitian dari ahli isi materi yaitu guru mata pelajaran bersangkutan dengan tingkat pencapaian 91%. Hasil penelitian dari ahli sistem e-learning dengan tingkat pencapaian 93%. Hasil penelitian dari uji coba lapangan dengan tingkat pencapaian 92% berada dalam kategori sangat baik. Pengembangan e-learning sistem komputer kelas X di SMKN 1 Kwanyar berada pada kategori sangat baik sehingga e-learning ini layak digunakan dalam pembelajaran.
Housing quality and suitability and older people’s use of formal and unpaid care: a process of de-optimisation?
Authors: Brimblecombe Nicola , Cartagena-Farias Javiera , Hu Bo , Stevens Madeleine , Rajagopalan Jayeeta
Published: November 2024

Good quality, suitable housing is an important part of preventing care needs, supporting people with care needs, and improving older people’s lives. However, many older people live in housing which is of poor quality and unsuitable for their needs; this is unequally distributed. While there is a developing literature on supported housing and long-term care, this is rather less on non-specialist housing, the type in which the vast majority of older people live. Informed by social determinants frameworks and the behavioural model of health service use, our mixed methods study sought to understand the relationship between housing condition and older people’s use of formal care or help from family and friends. Methods comprised secondary analysis of quantitative data from a large representative sample, the English Longitudinal Study of Ageing (2012/2013 to 2018/2019), and semi-structured in-depth interviews with 72 people aged 65 and older with care needs and/or their unpaid carers living in five localities in England. We found that poor quality or unsuitable housing can affect use of formal and/or unpaid care in two ways – indirectly through increasing or precipitating care needs thus necessitating help from another person, and directly through being a barrier to receiving care. Poor housing acting as a barrier to care use can result in unmet need for support.
Impact of Intra-Aortic Balloon Counterpulsation in Open-Heart Surgery: A Multivariate Analysis of Retrospective Observational Data
Authors: Sharma Sagar , Nah Jie Hui , Siddarth Venkateswaran , Lai Haoxing , Liang Shen , Ong Zhi Xian , Wu Duoduo , Luo Haidong , Chang Guohao , Kang Giap Swee , Kofidis Theo , Sazzad Faizus
Published: November 2024

Background
The use of intraaortic balloon pump (IABP) effectively reduces left ventricular afterload and significantly increases coronary perfusion pressure by raising aortic diastolic pressure. This study examined the short and medium-term outcomes of 22,540 adult cardiac surgical patients requiring an IABP.
Methods
From 2009 to 2018, 1114 patients (4.94%) undergoing open-heart surgery at a single tertiary cardiac hospital received IABP support and were included in this retrospective study. They were categorized into pre-operative (Group A, n = 577), intra-operative (Group B, n = 475), and post-operative (Group C, n = 62) IABP insertion groups.
Results
Cardiogenic shock occurred in 11.2% of cases, mainly in Group A. Hemodynamic instability (38.8%) drove IABP use in Groups A and C, while difficulty weaning from CPB was the primary reason in Group C. The overall operative mortality rate was 10.9%, highest at 25.8% postoperatively. Multivariate analysis identified significant predictors of mortality: age (OR: 1.067, 95% CI: 1.041–1.094, p < .001), higher BMI (OR: 1.071, 95% CI: 1.017–1.128, p = 0.009), pulmonary hypertension (OR: 2.085, 95% CI: 1.302–3.341, p = 0.002), renal disease (OR: 2.780, 95% CI: 1.556–4.967, p < .001), and cardiogenic shock (OR: 3.684, 95% CI: 2.066–6.569, p < .001). Complications were more common in Group C, especially with renal disease. Average preoperative and postoperative stays were 4.0 ± 4.8 days and 15.2 ± 20.4 days, respectively, with no significant differences between groups.
Conclusion
IABP might offer safety for open-heart surgery, with longer hospital stays potentially associated with high-risk patients. Pre-operative IABP prophylaxis could be crucial in high-risk open-heart cases to reduce mortality.
Ovarian function measures in normogonadotropic anovulation and subclinical thyroid dysfunction: a prospective cohort study
Authors: Gawron Iwona , Baran Rafal , Jach Robert
Published: November 2024

Purpose: To compare ovarian function measures in euthyroid women with normogonadotropic anovulation in subclinical hypothyroidism (SCH) or thyroid autoimmunity (TAI) to those without thyroid dysfunction.
Design: A prospective open-label cohort study analyzed anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone, estradiol and testosterone concentrations, ovarian volume, and polycystic ovarian morphology (PCOM) incidence between women with and without SCH or TAI in two study arms: polycystic ovary syndrome (PCOS) and hypothalamic-pituitary-ovarian dysfunction (HPOD).
Results: The prevalence of circulating thyroid peroxidase antibodies (TPOAb) was higher in the PCOS compared to the HPOD arm (p=0.006). No significant differences in the measured parameters were observed based on SCH or TAI status across the entire cohort or individual study arms, except for phenotype D of PCOS, where a greater volume (p=0.031) and higher incidence of physiological lesions (p=0.047) in the left ovary were noted in SCH, and phenotype A, where LH concentrations (p=0.038) were significantly higher in women without TAI. In the PCOS arm, thyroglobulin antibodies (TGAb) concentration correlated negatively with FSH (p=0.049) and positively with testosterone (p=0.012) concentrations, while in the HPOD arm, TPOAb and FSH concentrations were negatively correlated (p=0.028).
Conclusions: No clinically significant impact of SCH on ovarian function measures was demonstrated. Regarding TAI, significant correlations with still uncertain clinical significance were observed with FSH concentrations, both in PCOS and in HPOD. In view of the obtained results, the benefits of thyroxine supplementation to address menstrual irregularities and improve obstetric outcomes in the examined conditions, require support with clinical evidence.
Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote Ovarian Cancer Malignancy
Authors: Mehta Geeta , Horst Eric , Cotter Liam , Bonini Mia , Novak Caymen , Treacher Nina , Zhang Yeye , Jackson Zoe , Narayanan Ishwarya Venkata , Wuchu Fulei , Nenwani Minal , Fischer Zachary , Sunshine Alec , Lin Zequan , Tran Linh , Nagrath Deepak , Ljungman Mats , Maturen Katherine , DiFeo Analisa , Nordsletten David
Published: November 2024

The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. Although common routes of peritoneal dissemination are known to follow distinct paths of circulating ascites, the mechanisms that initiate these currents and subsequent fluid shear stresses are not well understood. Here, we developed a patient-based, boundary-driven computational fluid dynamics model to predict an upper range of fluid shear stress generated by the accumulation of ascites. We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled receptor mechanosignaling and the induction of an epithelial to mesenchymal-like transition through p38α mitogen-activated protein kinase and mucin 15 modulation. These findings along with a shear-induced immunomodulatory secretome position elevated shear stress as a protumoural signal. Together, this study suggests inhibition of the Gαq protein and restriction of ascites accumulation as maintenance strategies for overcoming mechanotransduction-mediated metastasis within the peritoneal cavity.
Single-cell transcriptomics reveals the landscape of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy and the potential resistance role of LGALS1
Authors: Yan Qihang , Chang Wuguang , Li Zhenguo , Wong Wingshing , Gong Li , Liang Dachuan , Yang Jie , Dai Shuqin , Wang Junye
Published: November 2024

Background
Neoadjuvant chemoradiotherapy (neoCRT) remodels the tumor microenvironment in esophageal squamous cell carcinoma (ESCC). This study aimed to analyze the impact of neoCRT on the immune landscape of ESCC and identify potential resistance genes using single-cell RNA-seq (scRNA-seq).
Methods
We obtained scRNA-seq datasets of ESCC from the GEO database and evaluated changes in the number and function of key T cells and myeloid cells following neoCRT. Malignant epithelial cells were analyzed using inferCNV and subjected to differential analysis to identify potential drug-resistance genes. The gene LGALS1, implicated in drug resistance, was further investigated. The effects of short hairpin RNA knockdown of LGALS1 on cisplatin sensitivity were assessed both in vitro and in vivo. Additionally, potential resistance pathways were explored through a protein-protein interaction network and gene set enrichment analysis.
Results
NeoCRT treatment resulted in the activation of T cells and myeloid cells within the tumor microenvironment, enhancing the anti-tumor immune response and improving tumor cell eradication compared to the surgery group. However, neoCRT simultaneously increased LGALS1 expression in tumor cells, which contributed to the development of drug resistance. Mechanistically, LGALS1 overexpression was associated with increased platinum resistance, enhanced DNA repair, resistance to apoptosis and epithelial-mesenchymal transition.
Conclusion
scRNA-seq analysis revealed that neoCRT significantly alters the immune landscape of ESCC. While neoCRT activates T cells and myeloid cells to target tumor cells effectively, it also induces LGALS1 overexpression, which contributes to drug resistance and potential relapse.
Steering Drilling Wellbore Trajectory Prediction Based on the NOA-LSTM-FCNN Method
Authors: Gao Yi , Wang Na , Li Fei
Published: November 2024

Aiming at the problem that it is difficult to accurately predict wellbore trajectory under complex geological conditions, the NOA-LSTM-FCNN prediction method for steering drilling wellbore trajectory is proposed by combining nutcracker optimization algorithm (NOA), long short-term memory network (LSTM) and fully connected neural network (FCNN). This method adopts an LSTM layer to receive input data and capture long-term dependencies within the data, extracting important information. The FCNN layer performs nonlinear mapping on the output of the LSTM layer and further extracts relevant features to enhance prediction accuracy. NOA is employed for hyperparameter optimization of the LSTM-FCNN model. Through experimental validation, the proposed method has shown significant improvement in prediction accuracy and strong adaptability compared to traditional machine learning and deep learning methods. In addition, it applies to various types of wellbore trajectory data, effectively enhancing wellbore trajectory prediction capabilities under complex geological conditions.
Integrative morphological, phytochemical, and molecular identification of three invasive and medicinal Reynoutria species
Authors: Stafiniak Marta , Bielecka Monika , Kujawa Krzysztof , Jezierska-Domaradzaka Anna , Pencakowski Bartosz , Basiak Aleksander , Matkowski Adam , Nawrot-Hadzik Izabela
Published: November 2024

In Poland, knotweed is represented by three species – Reynoutria japonica Houtt., Reynoutria sachalinensis (F.Schmidt) Nakai, and a hybrid between two former species - Reynoutria x bohemica J. Chrtek & A. Chrtková. Brought to Europe as ornamental plants, R. japonica and R. sachalinensis began to appear outside of cultivation areas due to their impressive ability to propagate vegetatively by rhizome. Currently, all three are classified as highly invasive alien species. Rhizomes of R. japonica and R. sachalinensis are rich sources of biologically active compounds and have been used in traditional Chinese and Japanese medicine. However, only R. japonica is accepted as an herbal drug source in the pharmacopoeias (Polygoni cuspidati rhizoma et radix). There is no data on the medical use of Bohemian knotweed, but this hybrid species is frequently misidentified as R. japonica. Traditionally used morphological markers were, however, often reported as insufficient in raw material identification. Qualitative HPLC/DAD/ESI-HR-QTOF-MS analyses were used to determine the chemical composition of the collected Reynoutria samples. The UHPLC-QTOF-MS analysis revealed a total of 117 detected compounds belonging to carbohydrates, stilbenes, flavan-3-ols, procyanidins, anthraquinones, organic acids, and naphthalenes. Out of these, the abundance of 6 compounds was estimated quantitatively. Based on LC-MS data for 117 compounds, the cluster analysis dendrogram categorised the 15 accessions into two distinctive clusters, revealing unequivocal separation of the R. sachalinensis from other taxa representatives. This study intended to explore genetic identity, diversity, and population structure using sequence-related amplified polymorphisms (SRAP), and start codon targeted (SCoT) markers correlated with morphological traits and metabolic profiles in 15 collections of three knotweed taxa. Both the SCoT and the SRAP markers were located in the medium (0.1 to 0.25) or high (0.30 to 0.40) levels of PIC (polymorphic information content) and were considered as differentiating. Based on their polymorphic SRAP and SCoT fragments, the cluster analysis dendrogram categorized the 15 accessions into three distinctive clusters, closely referring to three knotweed taxa. The highest correlation between dendrograms was observed between genetic and morphological data, with values of 0.85 according to Baker’s methodology. Lower correlations were noted between genetics and metabolomics, and between morphology and metabolomics. The study suggests the effectiveness of morphological, phytochemical and molecular combinations employing SCoT and SRAP marker systems to assess the origin of plant material, and proves them useful for clarifying the population structure and assessing spread, diversity and evolution of the invasive species such as Reynoutria spp.
Comparative Analysis of Antifungal Properties and Metabolic Profiles in Seagrass Species from Rameshwaram Island, India
Authors: Ameen Hazeena M , Athira A S , Jayadev Ayona , Prasad Geena , Gayathri N P , Nair Deepa Indira
Published: November 2024

Seagrasses have gathered increasing attention due to their multifaceted ecological roles. Apart from their ecological significance, seagrasses have potent antifungal properties, indicating potential for diverse applications. The antifungal efficacy of methanolic extracts derived from five seagrass species (Cymodocea serrulata, Cymodocea rotundata, Halodule pinifolia, Halophila ovalis, and Syringodium isoetifolium) was assessed against selected pathogenic fungal strains using the agar well diffusion method. The methanolic extract from different seagrasses exhibited notable antifungal activity against Penicillium chrysogenum (Cymodocea serrulata- 19.5mm Halodule pinifolia- 19.9mm Halophila ovalis- 10.3mm Syringodium isoetifolium- 9.6mm). Least inhibition was noted to Candida albicans (Cymodocea serrulate - 4.6 mm, Cymodocea rotundata - 4.3mm and Halodule pinifolia - 6.5 mm). The findings show that methanolic extracts from seagrasses Cymodocea serrulata, Halodule pinifolia, and Enhalus acoroides at concentrations of 500µg and 1000µg exhibited remarkable inhibition of almost all pathogens under study. The samples exhibiting significant antifungal activity were subjected to metabolite profiling using GC-MS. A total of 23 compounds were identified in the methanolic extract of seagrass Cymodocea serrulata, while 25 compounds were detected in the methanolic extract of Halodule pinifolia. This study lays the groundwork for developing bioactive natural products with applications in phytosanitary practices, offering the additional advantages of environmental safety and economic viability. The ecology and the significance of seagrass ecosystems of Rameshwaram Islands is also shown in the manuscript.
Polysaccharide Lyase PL3.3 possibly potentiating Clostridium difficile clinical symptoms based on complete genome analysis of RT046/ST35 and RT012/ST54
Authors: Zhang Sen , Ma Wen , Zhang Xin , Cui Weitong , Liu Youhan , Tian Xuewen , Wang Qinglu , Luo Ying
Published: November 2024

Clostridium difficile has rapidly become a major cause of nosocomial infectious diarrhea worldwide due to the misuse of antibiotics. Our previous study confirmed that RT046/ST35 strain is associated with more severe clinical symptoms compared to RT012/ST54 strain. We conducted comprehensive genome identification of the RT046/ST35 and RT012/ST54 strains using whole-genome sequencing technology. The RT046/ST35 strain had a genome length of 7,869,254bp with a GC content of 29.49%. The original length of the RT012/ST54 strain was 7,499,568bp with a GC content of 29.64%. Additionally, we detected plasmid1 in the RT046/ST54 strain. We found that the RT046/ST35 strain had more genomic islands compared to the RT012/ST54 strain, and we identified polysaccharide lyase (PL) in the region around 2.2M. Furthermore, we discovered that the increased severity of clinical symptoms in the RT046/ST35 strain compared to the RT012/ST54 strain was unrelated to virulence factors and emphasized the potential crucial role of PL in RT046/ST35. There were almost no differences in eggNOG annotation and KEGG annotation between RT046/ST35 and RT012/ST54. RT046/ST35 had more mRNA processes in GO annotation. In conclusion, our study suggests that the core factor contributing to the more serious clinical symptoms of the RT046/ST35 strain compared to the RT012/ST54 strain is possibly PL.
Antioxidant and UV photoprotective activitiy of lichenized fungi from Paramo de Sumapaz (Colombia).
Authors: Vargas David Gilberto Torres , Arango Lissy Marcella Nuñez , Ceballos Jaime Aguirre
Published: November 2024

Lichens or lichenised fungi are particularly abundant in harsh environments, Neotropical Paramos are unique mountain environments located in the northern Andes, face several treats due to human activities and climate change. In this study, the antioxidant and photoprotective activities of 5 Paramo lichens were evaluated. Antioxidant activity was obtained using DPPH and FRAP assays. Photoprotective parameters (SPF Sun Protection Factor, critical wavelength, spectral amplitude) were determined spectrophotometrically. All extracts showed DPPH inhibition higher than 70% at 200 µg mL− 1, while BHT achieved 92% at 20 µg mL− 1 and showed significant differences. Rock-inhabiting lichens such as Thamnolia and Cladonia performed better than phorophyte-growing lichens Lobariella, Peltigera and Everniastrum. Moreover, the extracts evaluated had moderate ferric ion reducing power and were statistically different from BHT. For protection against UV-B, the in vitro SPF were above 10 at 100 µg mL− 1 for all extracts except Peltigera. Lobariella was the most active at 100 and 200 µg mL− 1 (SPF: 17.37 ± 0.47 and 29.25 ± 1.68 respectively). Thamnolia, Cladonia and Lobariella can be highlighted as potential broad-spectrum filters (λcrit = 367.9; 364.2 and 355.8 nm), while Everniastrum can be proposed as UV-B and UVA-2 filter and Peltigera presented the smallest photoprotective activity. Consequently, Paramo lichens, especially species growing on rocks, soil or over exposed phorophytes can be proposed as sources of new photoprotective compounds, with the remarkable feature of their antioxidant capability, which is an improvement compared to synthetic sunscreens. These potential applications might help as conservation strategy for Paramo environments.
A Computational Mechanism for Encoding, Recalling and Forgetting of Real-Life Episodic Events
Authors: Jain Arvind Kumar , Shrivastava Rahul , Chauhan Nupa Ram , Tiwari Vivek
Published: November 2024

One of the most important aspects of the human memory system is episodic memory, by imitating them, an agent can achieve human intelligence. To achieve human cognitive abilities, this paper presents a computational mechanism that encodes and forgets the real life episodic events. The proposed model is based on bindings between roles and entities that encode the real-life conceptual activities. In addition, the model incorporates a computational gradual forgetting mechanism to achieve higher performance while controlling memory consumption over time. To verify the suggested model, an experimental investigate is conducted, wherein the evaluation is done based on event recalling’s hit ratio. The approach generates consistent performance and got an enhanced hit ratio in event recalling concerning prior methods.
A novel diimine two-tetradentate ionic macrocycle Schiff base ligand as a Colorimetric Chemosensor for the Detection of Fe 2+ andFe 3+ ions
Authors: kamroudi Mahrokh Razzaghi , Grivani Gholamhossein
Published: November 2024

In this paper, a novel diimine two-tetradentate ionic macrocycle Schiff base ligand (L) was synthesized by reacting 1,2-bis((1H-imidazol-1-yl)methyl)benzene (OB) with 5- chloromethyl salicylaldehyde in methanol and followed by the addition of ethylenediamine under refluxing conditions, and characterized by elemental analysis, FT-IR, UV–Visible, fluorescence, proton nuclear magnetic resonance (1H NMR), carbon-13 nuclear magnetic resonance (13C NMR), liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The sensing ability toward the metal ions of Mo5+, V4+, Cr3+, Al3+, Zn2+, Cd2+, Hg2+, Cu2+, Ni2+, Co2+, Mn2+, Sn2+, Pb2+, Fe3+, Fe2+, K+, Ag+, Mg2+, Ca2+, Ba2+ and Na+ was investigated in mixture of dimethyl sulfoxide (DMSO) and water (H2O) (2/8, v/v) solvent. The L is used as a colorimetric chemosensor for the detection of Fe2+ and Fe3+ ions, by a rapid and significant color change from yellow to brown and brownish red Respectively, by the naked eye and at room temperature. Also, the limit of detection (LOD) was obtained 0.45 µM for Fe2+ and 0.68 µM for Fe3+. Job’s plots indicated a 1:2 complexation stoichiometry between the sensor (L) and Fe ions. Moreover, the sensor (L) demonstrated reversible behavior upon the addition of EDTA. This probe (L) could be prepared into test paper strips for visual detection of Fe2+ and Fe3+ ions at room temperature.
Hyperchylomicronemia causes endothelial cell inflammation and increases atherosclerosis
Authors: Goldberg Ira , Izquierdo Maria Concepcion , Gonzalez Ainara , Basu Debapriya , Nasias Dimitrios , Kanter Jenny , Ho Tse Wing Winnie , Gjini Jana , Fisher Edward , Kim Jeffrey , Lee Warren , Bornfeldt Karin
Published: November 2024

The effect of increased triglycerides (TGs) as an independent factor in atherosclerosis development has been contentious, in part, because severe hypertriglyceridemia associates with low levels of low-density lipoprotein cholesterol (LDL-C). To test whether hyperchylomicronemia, in the absence of markedly reduced LDL-C levels, contributes to atherosclerosis, we created mice with induced whole-body lipoprotein lipase (LpL) deficiency combined with LDL receptor (LDLR) deficiency. On an atherogenic Western-type diet (WD), male and female mice with induced global LpL deficiency (iLpl-/-) and LDLR knockdown (Ldlrkd) developed hypertriglyceridemia and elevated cholesterol levels; all the increased cholesterol was in chylomicrons or large VLDL. After 12 weeks on a WD, atherosclerotic lesions both in the brachiocephalic artery and the aortic root were more severe in iLpl-/-/Ldlrkd mice compared to the control Ldlrkd mice. One likely mechanism for this is that exposure of the aorta to hyperchylomicronemia led endothelial cell inflammation. Thus, our data show that intact chylomicrons contribute to atherosclerosis, explain the association of postprandial lipemia and vascular disease, and prove that hyperchylomicronemia is not benign.
Space-Time Wavefront Synchronized Optoelectronics
Authors: Chang Chao , Zhang Chiben , Lou Jing , Zhang Jing , Wang Zhuochao , Ji Changyin , Huang Yindong , Li zhenfei , Zhu Weiren , Li Longyue , Cong Longqing , Hu Guangwei
Published: November 2024

Wireless communications feature high data rates, low latency, and ultra-reliable characteristics for future communications. It necessarily requires highly efficient, programmable, and multifunctional arrays in both spatial, temporal, and wave domains, thus compensating the path loss, extending spectral links, and enlarging spatial coverage. The current state of the art presents several challenges, including narrow bandwidth, limited efficiency, remarkable loss, and constrained coverage in full space with unconnected transmission-reflection-integrated links. Here, harvesting the optoelectronic-modulated arrays integrated with multi-wavelength response resonators, we report broadband single-layer modulation devices with the picosecond modulation speed via pulsed light, the maximum modulation efficiency that approaches the fundamental modulation limit, and space-time synchronous link between the transmission and reflection. It could modulate the signals in the picosecond level by pump light with low fluence of 100 μJ/cm2 and tailor the wavefront covering a large bandwidth. Two prototypes are fabricated with gradient and holographic phase distributions, where the 168° field-of-view for beam steering and nearly 100% similarity for holograms are realized, respectively. This novel scheme of arrays is promising to advance in wireless communication, and inspires more all-optical innovations in the field of nanophotonics and semiconductors.
HYDRO GEOPHYSICAL INVESTIGATION FOR GROUND SOURCE HEAT PUMP SYSTEM INSTALLATION IN SEMI-ARID REGION OF CAMEROUN
Authors:   Department of Physics, Teachers Training Higher School of NDjamena, Chad, P.O. Box 460, NDjamena, Chad., Diab D.A. , Domra J.K. ,   Department of Mines, Petroleum and Water Ressource Exploration, Faculty of Mines and Petroleum Industries,University of Maroua, PO Box 46, Maroua, Cameroon., Aretouyap Z. ,   Department of Architecture and Engineering Art, Institute of Fine Arts, University of Dschang, P.O Box 31, Foumban, Cameroon., Ghomsi F.E.K. ,   National institute of cartography P.O. Box 157, YaoundÃƒÂ©, Cameroon., Njandjock P.N ,   Department of Physics, Faculty of Science, University of YaoundÃƒÂ© I, PO Box 812, YaoundÃƒÂ©, Cameroon.
Published: November 2024

Hydrogeophysical parameters of the ground play a vital role in heat transfer of ground source heat pump (GSHP) systems. Then, the investigation of the ground is necessary for the design and planning of GSHPs. This paper deals with investigations of Hydrogeophysical parameters of GSHP systems in Cameroon. Eighty-four drillings with the average deep of forty-seven meters have been performed in the Far North region of Cameroun in order to get hydrogeological and hydro geophysical characteristics of ground for shallow energy utilization. The results of geological study, vertical electrical sounding, pumping test, thermophysical properties, groundwater property and well data could help to understand better the heat transfer of borehole heat exchanger (BHE) and geo localization of potential GSHP in residentials of Logone et Chari, Cameroon. Closed systems of GSHP could be installed in the study area.
Changes in hotel activities in Ukraine and Poland due to the war: Migration aspect
Authors: Okhrimenko Alla , Boiko Margaryta , Bosovska Myroslava , Vedmid Nadiia , Kulyk Mariia
Published: November 2024

Internal displacement to safer regions and migration abroad became a new phenomenon in Ukraine due to Russian military aggression. Accordingly, hotels began to provide services to a new category of consumers – internally displaced persons (in Ukraine) and migrants (abroad). In 2022, Poland received the most migrants from Ukraine due to its geographical position and significant economic ties. This study aims to identify changes in hotel activities in Ukraine and Poland caused by internal and external migration. The results are based on Computer Assisted Web Interviewing (CAWI) conducted in April-July 2023, to which 300 hotels in Ukraine and Poland were invited. Answers were received from 93 Ukrainian and 94 Polish hotels. The majority (66% in Ukraine and 62% in Poland) have a star rating of 2-3*, with an average capacity of 45 rooms in Poland and 49 in Ukraine. According to hotel managers, the level of occupancy of hotels increased on average – in Ukraine by 6% and in Poland by 13%. The specific weight of migrants in hotels in Poland was 23% of all customers; in Ukraine, it was 12%. Hotels in both countries began to introduce new services, attract different sources of cost coverage (however, Polish hotels used wider opportunities), and attract migrants to employment (34% in Poland and 7.5% in Ukraine), contributing to additional occupancy rates and financial stability. Changes in hotel operations caused by migration processes as a result of the war reflect their adaptability and economic sustainability.
Acknowledgment The paper shows the results of the study performed in 2021−2023 at State University of Trade and Economics at the request of the Ministry of Education and Science of Ukraine “Forecasting the impact of the tourism system on the country’s economy” (state registration number 0122U001559).The authors would like to express their gratitude to the Kirkland Research Program, the Leaders of Change Foundation, the Polish American Freedom Foundation, Polish Chamber of Commerce for Hotel Industry, and to those who helped to disseminate information about the survey, as well as to the Polish hotels and all those who expressed interest in the results.
Una respuesta jurídica dada y correcta para cada caso
Authors: Vigo Rodolfo L.
Published: November 2024

El propósito del presente trabajo refiere a la pregunta de si en el derecho hay una respuesta correcta para cada caso. Se ofrece un panorama de diez perspectivas teóricas diversas, aunque todas ellas presentes con diferente intensidad en nuestra cultura académica. Sin perjuicio que se privilegia la mirada de aquellas sobre la cuestión central que aquí se estudia, también se identifican otras tesis centrales que completan, fundan y explican aquella mirada. En ese panorama, el autor confiesa su adhesión a la iusfilosofía de inspiración aristotélica-tomista, expresada hoy especialmente en la obra de John Finnis, y desde ese marco se concreta un balance de aquellas diez lecturas, lo que se completa con hasta once agregados o precisiones de índole más bien personal.
¿Cuándo se afecta el interés social? Reflexiones sobre el amparo provisional a la luz del Constitucionalismo del Bien Común
Authors: Muñoz Acevedo Isidro E.
Published: November 2024

La suspensión en el juicio de amparo –mejor entendida como un amparo provisional– se encuentra supeditada a que “no se siga perjuicio al interés social”. Sin embargo, ¿cuándo y por qué razones podríamos considerar que se afecta al interés social? El presente artículo pretende dar respuesta a esta interrogante a partir del Constitucionalismo del Bien Común. Así, se argumentará que dicha teoría constitucional permite dotar de un significado sustantivo al interés social que posibilita reconocer la dignidad de todos los miembros de la sociedad y resulte congruente con los derechos humanos. Razonaremos que el interés social: (I) no se traduce en el beneficio de muchos, en perjuicio de unos pocos; (II) no se opone a los derechos humanos, ya que estos derechos lo conforman; y (III) no es un cheque en blanco para arropar cualquier preferencia subjetiva que la autoridad desee imponer a la sociedad.
Acerca de las etapas del constitucionalismo y de las generaciones de derechos humanos y de las leyes de protección de datos
Authors: Puccinelli Oscar
Published: November 2024

Las revoluciones independentistas e industriales, las guerras mundiales, la carrera espacial y las dos guerras frías, entre otros fenómenos, han tenido un alto impacto en distintos ámbitos y de hecho constituyeron hitos que sirvieron de bisagras para definir etapas en el constitucionalismo y en los derechos humanos. En la evolución de la protección de éstos, nos centramos en la gestación y desarrollo de uno que está estrechamente vinculado a las tecnologías de la información y de la comunicación (TICs) y que surgió como respuesta ante los avances sobre los derechos de las personas –en especial pero no exclusivamente sobre la intimidad- por parte de quienes tratan información personal: el “derecho a la protección de datos” (inicialmente rotulado “derecho a la autodeterminación informativa, que actualmente aporta una cantidad ingente de contenidos a los “derechos digitales”), refiriendo a las principales normativas gestadas en sus cinco generaciones, desplegadas entre 1970 y la actualidad.