bluuebunny/crossref_metadata_2025 huggingface dataset:
P029 Pharmacokinetic/Pharmacodynamic Analysis of Amiselimod, a Selective Sphingosine 1-Phosphate Receptor Modulator, in Healthy Subjects: Results From a Phase 1 Study
Authors: Lee Jimin , Lester Robert , O'Reilly Terry , Lowe Ezra , Slatkin Neal , Franklin Howard , Israel Robert
Published: December 2021

BACKGROUND:

Amiselimod is a selective sphingosine 1-phosphate receptor modulator in development for inflammatory bowel disease. It is converted to its active metabolite, amiselimod phosphate (amiselimod-P), and has a long half-life and slow accumulation to steady state. We evaluated a multiple-dose titration regimen to determine the plasma pharmacokinetic (PK) profile of amiselimod and amiselimod-P at steady state for the 0.4 mg QD therapeutic dose on day 13 and for the 0.8 mg QD supratherapeutic dose on day 26. We also investigated the pharmacodynamic (PD) effect of amiselimod on absolute lymphocyte counts (ALCs).

METHODS:

A randomized, double-blind, multiple-dose, placebo-controlled, parallel study with a nested crossover design assessed amiselimod and amiselimod-P. Healthy adults received a single dose of placebo followed by oral amiselimod, which was upwardly titrated in doses ranging from 0.4 to 1.6 mg QD to rapidly achieve steady-state concentrations for the 0.4 mg QD and 0.8 mg QD doses within a 28-day treatment period. The PK parameters of amiselimod and amiselimod-P (on days 1, 13 and 26) included the geometric mean (geometric coefficient of variation percentage [CV%]) maximum plasma concentration (Cmax), median (minimum, maximum) time to Cmax (Tmax), geometric mean (geometric CV%) area under the concentration-time curve (AUC) from time 0 to the last measurable concentration, and geometric mean (geometric CV%) AUC from time 0 to 23.5 hours post dose (AUC0-23.5). Multidose PD were evaluated by changes in ALCs.

RESULTS:

The PK population included 95 amiselimod-treated participants and the PD population included 190 participants who received amiselimod or placebo. On day 13, the steady-state AUC and Cmax for amiselimod 0.4 mg QD increased by 10-fold for amiselimod and by 4-fold for amiselimod-P compared with day 1. On day 26, the steady-state AUC0-23.5 and Cmax for amiselimod 0.8 mg QD increased by 1.9-fold for amiselimod and by 1.8-fold for amiselimod-P compared with day 13. The median Tmax of plasma amiselimod and amiselimod-P were similar on all 3 days and were reached at 11 to 12 hours post dose for amiselimod and at 10 hours post dose for amiselimod-P. The mean ALCs for amiselimod exhibited a gradual decrease from pre-dose (1.681 × 103/uL) to a nadir of 0.424 × 103/uL on day 27.

CONCLUSION:

The abbreviated amiselimod dosing titration regimen reached steady state within 14 days for the therapeutic 0.4 mg QD regimen and within 26 days for the supratherapeutic 0.8 mg QD regimen; expected decreases in ALCs were observed following amiselimod.
P046 Tofacitinib Induced Resolution of Severe Colitis and Reactive Atypia in an Adolescent Patient With IBD
Authors: Crawford Erin , Kim Sandra
Published: December 2021

CASE:

Tofacitinib is an anti-JAK/STAT small molecule approved for treatment of adults (but not children and adolescents) with moderate to severe ulcerative colitis. Data is limited in children and teens although two major centers have shown efficacy as both mono- and dual - combination therapy using tofacitinib in pediatric patients refractory to anti-TNF agents. We present a 16-year-old female diagnosed with inflammatory ileocolonic Crohn’s disease without upper gastrointestinal involvement after presenting with several months of abdominal pain, diarrhea, and unintentional weight loss. Laboratory evaluation was notable for normal inflammatory markers, albumin and complete blood count and an elevated stool lactoferrin. Initial endoscopic evaluation revealed moderate to severe pancolitis and patchy ileitis; biopsies noted mild chronic active ileitis and moderate to severe chronic active pancolitis without dysplastic or atypical changes. She was started on infliximab for induction and maintenance therapy and dosage was increased due to suboptimal levels and marginal symptomatic improvement. However, despite increased dosing plus a course of budesonide (Uceris), she had minimal improvement in her symptoms and ongoing elevation of her lactoferrin. Given an equivocal result on a Clostridium difficile testing (GDH antigen positive only), she was started on oral vancomycin which resulted in mild improvement, but not resolution, of diarrhea and abdominal pain. This was continued after completion of a 14-day course (and subsequent negative testing) due to increased stool frequency with discontinuation of the medication and improvement with reinitiating it. She had severe pancolitis (Mayo 2 – 3) but normal TI on repeat colonoscopy 5 months after diagnosis. Biopsies (reviewed by a panel of adult GI pathologists) were notable for reactive atypia with features concerning for early dysplasia in the ascending and descending colon. Due to disease severity and rapid progression plus histologic changes concerning for possible dysplasia despite optimized therapy with infliximab and repeat negative C. difficile testing, she was started on tofacitinib 10 mg twice daily along with oral vancomycin. She had complete resolution of diarrhea, abdominal pain, and early satiety within a week; repeat fecal lactoferrin was negative (<30). She underwent repeat colonoscopy with chromoendoscopy 5 months after initiation of tofacitinib which revealed mild acute ileitis but no active colonic inflammation, atypia or dysplasia. This is the first report to our knowledge that an adolescent patient with colonic predominant Crohn’s disease has complete resolution of atypia and possible early dysplasia with tofacitinib therapy.
P049 Investigation of Liver Diseases by Ultrasound in Patients With Inflammatory Bowel Disease
Authors: Shintaku Daniel , Lopes Marina , de Oliveira Ana Carolina , Beraldo Rodrigo , Godoi Giovana , Castelhano Natalia , Pereira Jessica , Vulcano Daniela , de Oliveira Ellen Cristina , Herrerias Giedre , Saad-Hossne Rogerio , Baima Julio , Barbosa Walnei , Silva Giovanni , Sassaki Ligia
Published: December 2021

BACKGROUND:

Inflammatory Bowel Disease (IBD), which can be divided into Crohn’s Disease (CD) and Ulcerative Colitis (UC), is an immune mediated disease featured by gastrointestinal tract involvement. Hepatic disease, such as non-alcoholic fatty liver disease (NAFLD), cirrhosis, cholelithiasis, hepatic thromboembolic events and primary sclerosing cholangitis (PSC) are some hepatic complications presented by IBD patients. Since these hepatic disorders have a higher prevalence in IBD patients, ultrasonography is a noninvasive low-cost versatile tool, that allows to identify these manifestations at early stages. Therefore, this study aims to analyze the prevalence of hepatic diseases in patients with IBD.

METHODS:

A cross-sectional study was performed in a single IBD center, Brazil. This study considered clinical and sociodemographic data of these individuals, besides the evaluation of disease activity, biochemical tests, and liver ultrasound with doppler. Statistical analysis: descriptive, association tests.

RESULTS:

71 patients were included, 34 had CD and 37 had UC, mean age 45.32 ± 13.59 years, 63.38% women. Among CD patients, 42.42% have ileocolonic involvement, 50% penetrating behavior and 39.4% perianal involvement. Among patients with UC, most patients have pancolitis (72.22%). Most patients were in clinical (CD: 93.55%, UC: 63.89%) and endoscopic (47.14%) remission. The main medications used were azathioprine (46.48%), infliximab (40.85%), salicylates (28.17%), corticosteroids (16.9%) and adalimumab (11.27%). According to ultrasound, NAFLD was found in 32 (45.07%) patients: 40.63% mild, 40.63% moderate and 18.75% severe. Furthermore, we found a correlation between liver steatosis and blunt liver edge (p < 0.0155). Only 2 patients presented with choledocholithiasis. One patient had features of chronic liver disease such as irregular surface, heterogeneity of a hepatic parenchymal echo and bluntness of the liver edge. No signs of thrombosis were found in portal, splenic or superior mesenteric veins.

CONCLUSION:

A higher prevalence of NAFLD was found in patients with IBD, and no signs of thrombosis were found in the splanchnic system.
Ultrasonographic atlas of splenic lesions
Authors: Choi Gayoung , Kim Kyeong Ah , Lee Jinhwan , Park Yang Shin , Lee Jongmee , Choi Jae Woong , Lee Chang-Hee
Published: December 2021

Ultrasonography (US) is widely used for abdominal imaging. Its noninvasiveness, extensive range of application, and low cost make US a useful and valuable tool for the detection, diagnosis, and follow-up of splenic abnormalities. Concomitantly with the increasing frequency of imaging, more splenic lesions are being discovered and the requirements for the differential diagnosis are rising. In this pictorial essay, we introduce the representative US findings of many different splenic lesions, including normal sonographic findings, normal variants and congenital anomalies, infectious conditions, benign and malignant neoplasms, and non-neoplastic lesions. Knowledge of the US features of various splenic lesions will help narrow the differential diagnosis and guide clinical decision-making.
Ideología, gramática y discurso: análisis y caracterización de la realización de significados ideacionales, interpersonales y textuales en diferentes expresiones –sincrónicas y diacrónicas– de los discursos sociales
Authors: Mónaco Fabián
Published: December 2021

En el campo de las humanidades y las ciencias sociales se ha fortalecido, desde la última mitad del siglo XX, la dimensión constitutiva del lenguaje en la relación hombre-mundo, así como el reconocimiento del carácter simbólicamente mediado de la conciencia, lo cual ha permitido reformular desde diversas posiciones teóricas, problemáticas clásicas referidas a las relaciones entre la estructura social, el contexto cultural y los discursos sociales que las atraviesan. El desarrollo conceptual de la LSF considera que el lenguaje humano está organizado a partir de tres metafunciones. Estas metafunciones son una abstracción para explicar la naturaleza universal del lenguaje y son las siguientes: la metafunción ideativa que se realiza en la léxico-gramática de una lengua a través del sistema de Transitividad, la metafunción interpersonal que se realiza en la léxico-gramática a través del sistema de modo/resto y la metafunción textual que se realiza en la Léxico-gramática a través del sistema de tema-rema. A partir de este desarrollo ininterrumpido, la LSF se ha convertido hoy en un potente marco teórico para el análisis de diversos géneros discursivos. Este proyecto está organizado a través de tres trayectos, los dos primeros responden a una dimensión diacrónica de los textos y discursos, el tercero se centra en la dimensión sincrónica.
Trastorno del espectro del autismo, abordaje metodológico y aportaciones de las tecnologías
Authors: Montero de Espinosa Espino Guadalupe
Published: December 2021

El trastorno del espectro del autismo cada día está más presente en la escuela, siendo necesario para el profesorado conocer y comprender las características más relevantes del alumnado y las necesidades que se generan en el día a día de la persona. Una adecuada respuesta metodológica —haciendo uso de principios específicos de intervención— y el conocimiento de las aportaciones que puede realizar la tecnología, favorecerá el proceso de aprendizaje y la participación escolar.
Educación Física, imprescindible en alumnos con necesidades educativas especiales
Authors: Alonso Panizo José Ángel , Castañares Ávila Raquel , Moraleda Dussaillant Alberto , Quiñones Ledesma Guiomar
Published: December 2021

En la Fundación A LA PAR llevamos más de 70 años trabajando con las personas con discapacidad intelectual por sus derechos y su participación en nuestra sociedad, diseñando apoyos donde encuentran barreras.

Una de las principales herramientas que utilizamos para alcanzar el objetivo anteriormente descrito es la práctica de actividad física adaptada (AFA), entendida como un cuerpo de conocimientos interdisciplinares dedicados a la identificación, aceptación y solución de las diferencias individuales en actividad física, adecuándolas al contexto en el que se desarrollan, en nuestro caso dirigido a jóvenes y adolescentes con discapacidad intelectual.

El objetivo de este análisis, es el de presentar todas las propuestas que se desarrollan desde el área de Educación Física para conseguir mejoras significativas en cuanto a la inclusión social se refiere, a través del deporte.
O passo a passo da redação científica para o jovem pesquisador
Authors: Moraes Sylvio Luiz Costa de
Published: December 2021

Por onde devo começar a redação da minha pesquisa? Essa é uma pergunta comum do jovem pesquisador. As orientações recebidas podem, algumas vezes, resultar em dúvidas residuais que, de certa forma, podem gerar dificuldades na organização e elaboração da redação científica. O primeiro passo é selecionar a revista para publicar, pois o trabalho deverá seguir suas normas de publicação. Muito longe de pretender ensinar o como escrever, aqui seguem algumas sugestões que poderão facilitar a sequência de construção do texto, já que o “núcleo do trabalho” é composto por quatro partes, ordenadas no texto de maneira diferente: Material e Métodos, Resultados, Discussão e Introdução.
Uma entrevista com Valfrido Antonio Pereira Filho
Authors: Pereira Filho Valfrido Antonio
Published: December 2021

»Graduado em Odontologia pela Faculdade de Odontologia de Araraquara-UNESP.
» Mestre e Doutor em Cirurgia e Traumatologia Buco-Maxilo-Facial pela FOP-UNICAMP.
» Professor Associado da Disciplina de Cirurgia e Traumatologia Buco-Maxilo-Facial da Faculdade de Odontologia de Araraquara-UNESP.
» Pós-Doutorado em Cirurgia e Traumatologia Buco-Maxilo-Facial pela FOP-UNICAMP.
Marktplatzsystem für Naturschutzmaßnahmen in der Landwirtschaft
Authors: Schulze Christoph
Published: December 2021

Wie kann Naturschutz alternativ zu den bekannten Agrarumwelt- und Klimamaßnahmengefördert werden und welche Rollen können dabei Unternehmen und Privatpersonen spielen? Ein Marktplatzsystem könnte zukünftig zusätzliche Mittel für Agrarumweltmaßnahmen schaffen.
Funcionamiento familiar y calidad de vida relacionada con salud: una revisión narrativa
Authors: Pérez-Caro Ana María , Moreno-Méndez Jaime Humberto
Published: December 2021

El funcionamiento familiar hace referencia a la calidad de las interacciones que
se construyen entre los miembros que conforman la familia, las cuales se pueden
constituir en factores protectores o de riesgo cuando uno de sus miembros requiere
afrontar alguna condición médica. Si el afrontamiento es adecuado, la persona puede
alcanzar una mayor calidad de vida y, en este sentido, un mayor bienestar físico, psicológico
y social. Por esto, el funcionamiento familiar y la calidad de vida relacionada
con salud se han abordado desde diferentes investigaciones empíricas, con diferentes
poblaciones y en condiciones médicas diversas, con el fin de determinar su relación a
partir de metodologías cuantitativas y cualitativas. En el presente estudio se presenta
una revisión narrativa de 13 artículos empíricos entre 2013 y 2020, de las bases de
datos Science Direct, Scopus y EBSCOhost. Las temáticas con operador booleano
fueron “quality of life” OR “health-related quality of life” AND “family functioning”
a partir de alguna condición médica y sus correspondientes traducciones al español,
para identificar las asociaciones entre estas variables. En los resultados se encontró
que hay evidencia sobre la asociación entre el funcionamiento familiar y la calidad de
vida relacionada con la salud.
Topografias afetivas na ficção de Chico Buarque
Authors: Borowski Gabriel
Published: December 2021

This text is an attempt to discuss the affective dimension of the experience of the city in three novels by the Brazilian writer and composer Chico Buarque. In Estorvo (1991) the protagonist is unable to create bonds with the urban space and his perception of the city is a blend of actual observation and his delirious subjectivity. In Budapeste (2004) the main character is experiencing the capital of Hungary as an affective representation of the actual place. In Leite derramado (2009) the narrator is organising his story through affective memories of significant places.
Ballast water management: technology choice comparing TODIM and THOR 2
Authors: Simões Gomes Carlos Francisco , Autran Monteiro Gomes Luiz Flavio , Duncan Rangel Luís Alberto , Tenório Fabrício Maione , Santos Marcos dos
Published: December 2021

This paper approaches the problem of ballast water treatment in ships. This has been identified as one of the four greatest threats to the world’s oceans. Solutions that have been considered for solving the problem are alternative water treatment technologies. In the case study reported in this paper three major water treatment technologies have been evaluated with the help of twenty-six criteria, quantitative as well as qualitative by using two discrete multicriteria methods, TODIM and THOR 2. The THOR 2 consists of the axiomatic evolution of the THOR method and both THOR 2 and THOR are made available through the THOR Web platform. Five groups of evaluation criteria are then considered: practicality; biological effectiveness; cost/benefit ratio; time frame for the implementation of standards; and environmental impact of the process' sub-products. In this paper a case study on choosing a ballast water treatment technology is presented. Three alternative ballast water management technologies are proposed by experts in the field and are evaluated with the help of twenty-six criteria, quantitative as well as qualitative. Each ballast water management method is described by a list of twenty-six attributes or criteria. After setting the problem in a clear way and consulting different experts, the two separate applications of both TODIM and THOR 2 are performed. What is denoted as Management Method #1 is indeed chosen as the best alternative according to both methods. The conclusion is that those two methods, although conceptually and analytically quite different, lead essentially to the same main results.  Two other applications of both TODIM and THOR have indeed confirmed the convergence of results in spite of the conceptual and technical differences between the two methods. This suggests that formulating a decision problem in a correct, clear-cut way can be at least as important as the technical characteristics of the method per se.
COVID-19: a decision-making approach for evaluating the economic sectors of india during pandemic
Authors: Gupta Srikant
Published: December 2021

The advent of COVID-19 has escalated into a pandemic and, as a result of infected cases and human fatalities, it tends to rise day by day across the globe. This also ignited concerns of a looming fiscal slump and recession on the different economic sectors as well. The effect of this pandemic is much more significant in developing countries like India due to the already declining growth rate, inadequate health services, and a growing population residing in severe poverty.  This paper attempts to understand the impact of COVID‐19 pandemic on the Indian economic sectors by employing a hierarchical approach, based on multi-criteria analysis to understand the impact on primary, secondary, tertiary and quaternary sectors by concerning the political, economic, socio‐cultural and technology consequences of COVID‐19. A process-based multi-criteria hierarchical approach has been used to determine the effect of the same and has been prioritized in the sequential sequence.
“Are you gay or do you do gay?” Subjectivities in “gay” stories on the Persian sexblog shahvani.com
Authors: Guitoo Arash
Published: December 2021

The main goal of this study is to demonstrate the influence of local-traditional perceptions of sexuality in the construction of subjectivity among men involved in same-sex sexual practices in contemporary Iran. In order to do so, I shall briefly outline some essential features of the local-traditional understanding of sexuality, which I consider to be epistemologically and ontologically different from the modern concept of human sexuality. Subsequently, the continuity of the local-traditional understanding of sexuality in the identity construction of those individuals involved in same-sex sexual practices will be demonstrated through an inquiry on contemporary pornographic stories written by users of an online platform with erotic and pornographic content. I will argue that the perception of and the explanation for same-sex desire as well as the categorisations of subjects found in these stories point to the predominance of local-traditional patterns of thought in the imagination of the authors of these stories. However, it will also be demonstrated that the modern idea of sexuality is present among some other users of this platform, whose modern worldview is in conflict and competition with the local-traditional views on sexuality. This conflict is best illustrated in the commentary sections of the stories on this website, where modern-thinking users question the “truth” of the epistemology behind these local-traditional narratives. This modern users’ criticism of the local-traditional view on same-sex desire shall be addressed in the last part of the paper.
Ricci flow on manifolds with boundary with arbitrary initial metric
Authors: Chow Tsz-Kiu Aaron
Published: December 2021

In this paper, we study the Ricci flow on manifolds with boundary. In the paper, we substantially improve Shen’s result [Y. Shen,
On Ricci deformation of a Riemannian metric on manifold with boundary,
Pacific J. Math. 173 1996, 1, 203–221] to manifolds with arbitrary initial metric. We prove short-time existence and uniqueness of the solution, in which the boundary becomes instantaneously totally geodesic for positive time. Moreover, we prove that the flow we constructed preserves natural boundary conditions. More specifically, if the initial metric has a convex boundary, then the flow preserves positive curvature operator and the PIC1, PIC2 conditions. Moreover, if the initial metric has a two-convex boundary, then the flow preserves the PIC condition.
Ressourcen der Sportvereine in Zeiten der Corona-Pandemie
Authors: Braun Sebastian , Burrmann Ulrike , Sielschott Stephan
Published: December 2021

Öffentliche Diskussionen über Auswirkungen der Corona-Pandemie auf das Vereinswesen in Deutschland und speziell auch das Sportvereinswesen werden derzeit breit geführt. Beispielsweise limitier(t)en physische Abstandsregeln und Kontaktbegrenzungen die Kernaktivitäten der Sportvereine im Hinblick auf die sportliche Praxis, aber auch weitergehende Geselligkeiten im Vereinsleben. Der Beitrag liefert eine empirische Momentaufnahme im Hinblick auf ausgewählte Strukturmerkmale des Sportvereins und vergleicht darüber hinaus die Sportvereine mit anderen freiwilligen Vereinigungen. Dabei konzentriert er sich auf die Frage, wie sich Mitgliedschaften, das ehrenamtliche und freiwillige Engagement der Mitglieder und deren Bindung an den Verein bis in den „zweiten Lockdown“ des Winters 2020/21 hinein verändert haben. Auf empirischer Ebene werden Datenanalysen einer Bevölkerungsbefragung in Deutschland präsentiert, die vom 14.12.2020 bis zum 06.01.2021 als repräsentative Online-Befragung von 3.247 Personen im Alter ab 18 Jahren durchgeführt wurde. Die Ergebnisse zeigen, dass die Auswirkungen der Corona-Pandemie im Feld der freiwilligen Vereinigungen im Allgemeinen und speziell auch im Sportvereinswesen deutlich sichtbar sind. Das betrifft insbesondere die markanten Vereinsaustritte und deutlich geringeren Vereinseintritte von Personen im Erwachsenenalter. Zwar ist bei den Sportvereinen auch das ehrenamtliche und freiwillige Engagement der Mitglieder rückläufig, aber wesentlich stabiler als bei den Mitgliedschaften. Bemerkenswert ist, dass trotz der deutlich sichtbaren Einschränkungen des Vereinslebens (z. B. Vereinsangebote, Geselligkeiten, Mitgliederversammlungen) die Bindung der erwachsenen Vereinsmitglieder an die Sportvereine stark ausgeprägt ist.
Wer schuldet hier eigentlich wem?
Authors: Sorg Christoph
Published: December 2021

Mit der Covid-19-Pandemie und der Frage nach der Welt, in der wir nach der Pandemie leben wollen, stellen sich schuldenpolitische Fragen, die uns aus anderen Krisenzeiten vertraut sind. Was soll mit Haushalten und Unternehmen passieren, die aufgrund von Entwicklungen höherer Gewalt nun hoch verschuldet sind? Wer wird gerettet, wer nicht – und wer zahlt für die Krise? Ein Blick in das letzte Jahrzehnt zeigt eine Geschichte politischer Mobilisierung, die für andere Formen von Schuldenpolitik kämpfte, und in der daher alternative Zukünfte einer post-pandemischen Welt sichtbar werden. In diesem Text versuche ich diese Geschichte zu rekonstruieren, damit aus ihr Lektionen für die aktuelle Situation gezogen werden können. Der erste Teil erklärt zunächst das Konzept der „umkämpften Schuldenpolitik“ und geht auch kurz auf die Methodologie und Methoden meiner Forschung ein. Teil zwei rekonstruiert die jüngere Geschichte umkämpfter Schuldenpolitik von der südlichen Schuldenkrise seit den 1970ern bis zu den jüngeren Platzbesetzungen um 2011. Der dritte und finale Abschnitt diskutiert dann die Utopien dieser schuldenpolitischen Bewegungen, die für alternative Zukünfte kämpfen.
Stability analysis and abundant closed-form wave solutions of the Date–Jimbo–Kashiwara–Miwa and combined sinh–cosh-Gordon equations arising in fluid mechanics
Authors: Seadawy Aly R. , Ali Asghar
Published: December 2021

In this manuscript, several types of exact solutions including trigonometric, hyperbolic, exponential, and rational function are successfully constructed with the implementation of two modified mathematical methods, namely called extended simple equation and modified F-expansion methods on the (2 + 1)-dimensional Date–Jimbo–Kashiwara–Miwa and the combined sinh–cosh-Gordon equations. Diverse form of solitary wave solutions is achieved from exact solutions by passing the special values to the parameters. Some solution are plotted in the form of 3D and 2D by assigning the specific values to parameters under the constrain condition to the solutions. These approaches yield the new solutions that we think other researchers have missed in the field of nonlinear sciences. Hence the searched wave’s results are loyal to the researchers and also have imperious applications in applied sciences.
Von der Corona-bedingten Schuldenaufnahme zur Wiedereinhaltung der Schuldenbremse
Authors: Feld Lars P. , Nöh Lukas , Reuter Wolf Heinrich , Yeter Mustafa
Published: December 2021

Die Wiedereinhaltung der Schuldenbremse auf der Bundesebene macht in den kommenden Jahren eine Reduktion der im Rahmen der Corona-Pandemie stark gestiegenen Neuverschuldung notwendig. In diesem Beitrag stellen die Autoren die fiskalpolitischen Spielräume im Vergleich mit der maximal zulässigen Nettokreditaufnahme unter der Schuldenbremse dar. Diese Spielräume erhöhen sich insbesondere durch den Abbau der Rücklagen sowie durch sinkende Zinsausgaben. Zudem passt die Konjunkturkomponente den fiskalischen Spielraum symmetrisch an die konjunkturellen Gegebenheiten an und ermöglicht damit das uneingeschränkte Wirken der automatischen Stabilisatoren. Verbesserungen der Verfahren, die zu weniger revisionsanfälligen Schätzungen des Produktionspotenzials führen, können dabei helfen, die Spielräume durch die Konjunkturkomponente der Schuldenbremse verlässlicher zu bestimmen. Einschränkend wirken unter anderem die Tilgungszahlungen, die sich durch die Inanspruchnahme der Ausnahmeregelung ergeben. Die Autoren zeigen alternative Möglichkeiten für die Tilgungszahlungen auf, mit denen die Tilgungen zusammengefasst und konjunkturgerecht gestaltet werden können.
Lebenslanges Lernen als Standortfaktor?
Authors: Neumann Uwe
Published: December 2021

In the process of occupational changes connected to digitisation, lifelong learning continues to gain in importance. Using microdata from the German microcensus for 2011 and 2016 the article finds that in North Rhine-Westphalia participation in adult education is significantly lower than in other Länder. Most importantly, it is less likely for workers in North Rhine-Westphalia to participate than for workers with a similar qualification and age in Southern and Northern Germany. Among the policy measures designed to meet the challenges of ongoing structural change, encouragement of participation in adult education is therefore a likely step.
Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome
Authors: McGregor Ronald , Wu Ming-Fung , Holmes Brent , Lam Hoa Anh , Maidment Nigel T. , Gera Joseph , Yamanaka Akihiro , Siegel Jerome M.
Published: December 2021

We previously found that human heroin addicts and mice chronically exposed to morphine exhibit a significant increase in the number of detected hypocretin/orexin (Hcrt)-producing neurons. However, it remains unknown how this increase affects target areas of the hypocretin system involved in opioid withdrawal, including norepinephrine containing structures locus coeruleus (LC) and A1/A2 medullary regions. Using a combination of immunohistochemical, biochemical, imaging, and behavioral techniques, we now show that the increase in detected hypocretin cell number translates into a significant increase in hypocretin innervation and tyrosine hydroxylase (TH) levels in the LC without affecting norepinephrine-containing neuronal cell number. We show that the increase in TH is completely dependent on Hcrt innervation. The A1/A2 regions were unaffected by morphine treatment. Manipulation of the Hcrt system may affect opioid addiction and withdrawal.

SIGNIFICANCE STATEMENTPreviously, we have shown that the hypothalamic hypocretin system undergoes profound anatomic changes in human heroin addicts and in mice exposed to morphine, suggesting a role of this system in the development of addictive behaviors. The locus coeruleus plays a key role in opioid addiction. Here we report that the hypothalamic hypocretin innervation of the locus coeruleus increases dramatically with morphine administration to mice. This increase is correlated with a massive increase in tyrosine hydroxylase expression in locus coeruleus. Elimination of hypocretin neurons prevents the tyrosine hydroxylase increase in locus coeruleus and dampens the somatic and affective components of opioid withdrawal.
Alternativni pogled na međuodnos priljeva stranih direktnih investicija i gospodarskog rasta u zemljama srednje i istočne Europe
Authors: Kusanović Tino
Published: December 2021

U radu se na uzorku država srednje i istočne Europe teorijski i empirijski analizira međuodnos stranih izravnih investicija i ekonomskog rasta. Dostupna istraživanja o navedenom međuodnosu ne iznose jednoznačni zaključak o smjeru i intenzitetu utjecaja dviju predmetnih varijabli, dovodeći u pitanje a priori pozitivne učinke FDI-a na ekonomski rast zemlje primateljice ulaganja. Istraživanja pritom naglašavaju da potencijalni učinci inozemne štednje na gospodarstvo zemlje primateljice ovise o stupnju ekonomskog i institucionalnog razvoja zemlje kao i o modelu rasta koji je zemlja usvojila. Polazeći od postavki postkejnesijanske ekonomske teorije, u radu se polazi od pretpostavke da većina država iz uzorka istraživanja ima usvojen demand led growth model rasta. Istraživanje pokriva uzorak od 15 država srednje i istočne Europe te razdoblje 1995. – 2016. Empirijsko istraživanje provedeno je u dva koraka; u prvom je koraku na temelju testa Grangerove kauzalnosti utvrđen smjer međuutjecaja FDI-a i varijable ekonomskog rasta pri čemu je utvrđeno da stopa rasta BDP-a vodi povećanom priljevu ulaganje, dok obrnuti slučaj ne vrijedi. U drugom koraku, poduzetom panel analizom testira se utjecaj ekonomskog rasta i odabranih kontrolnih varijabli na ukupni priljev FDI-a. Zaključno, empirijski rezultati teorijski se obrazlažu u kontekstu postkejnesijanske ekonomske teorije temeljeno na pretpostavci da inozemna štednja (kapital) u slučaju država niske i srednje razine dohotka uglavnom vodi povećanju osobne potrošnje zbog aprecijacije realnog tečaja vodeći posljedično povećanju deficita tekućeg računa balance plaćanja i stvaranju (makro)ekonomskih neravnoteža.
Određivanje optimalne rute u mreži turističkih atrakcija grada Pule
Authors: Kostelić Katarina , Cvek Loris , Draženović Marjan , Drezga Luka , Grbac Axel , Pajković Matteo
Published: December 2021

U radu se razmatra određivanje optimalne rute po turističkim atrakcijama. Na primjeru odabranih deset atrakcija u gradu Puli, dokazuje se da je problem optimalne rute rješiv modeliranjem po uzoru na model putujućega trgovačkog predstavnika (TSP) te primjenom evolucijske metode. Postavljeni problem odnosi se na određivanje pješačke rute i modeliran je iz perspektiva minimizacije udaljenosti i minimizacije vremena potrebnog za obilazak. Prikaz rješavanja korištenjem MS Excela upućuje na mogućnost jednostavne i intuitivne pripreme podataka za analizu te relativno brzog utvrđivanja rješenja. Rezultati upućuju na mogućnosti upotrebe pri organizaciji obilaska u turističkoj destinaciji, prednosti i nedostatke primijenjene metode, ali i prednosti upotrebe kvantitativnih metoda uupravljanju turističkim atrakcijama. Uočena fleksibilnost primjene rezultata otvara mogućnosti daljnjeg obogaćivanja modela, ali i daljnji razvoj u obliku integracije u sustav potpore u upravljanju destinacijom kvantitativnim metodama, uz doprinos održivosti turizma destinacije.
How Do Villagers Solve Their Legal Problems? A Study of District Court (Peradilan Desa) for Dispute Settlement Process
Authors: Wahanisa Rofi , Lestari Dwi , Rahman Malik Akbar Mulki , Putri Fadhilah Rizky Aftriani
Published: December 2021

This study aims to provide another alternative in resolving conflicts in Lerep Village which is called the District Court (Peradilan Desa). The village court aims to help resolve conflict problems in Lerep Village so that there is no accumulation of cases in the surrounding District Courts. Village justice is carried out by familial mediation between the person in dispute with the head of the local hamlet and the village head. The decisions given are in the form of suggestions from the hamlet head and village head which are not binding. District justice (Peradilan Desa) is a win-win solution to the conflict in Lerep Village. However, the implementation of this District court still has shortcomings. One of them is the district court does not yet have a reference for regulations in its implementation. Another deficiency is the lack of knowledge in the legal field of the parties acting as intermediaries, such as the hamlet head and village head. The research method used in this research is legal research, legal research is often referred to as doctrinal or normative. Normative legal research examines principles, numbers, concepts, rules, laws and regulations, research decisions, agreements and doctrines that are placed by law as a norm system by examining library studies. The conclusion in this study is that specific regulatory references are needed to regulate the running of village courts. And there must be training to provide basic knowledge to the parties concerned.
Integrated Land Registration System: Between Legal Certainty and Challenges (Case of Semarang City)
Authors: Rachmawati Fairus Augustina , Choirinnisa Shafa Amalia , Latif Latif
Published: December 2021

In providing legal certainty for the control and ownership of community land parcels, the government carries out a program of registration and data collection of land parcels or what is called Complete Systematic Land Registration (PTSL). In its implementation, the city government of Semarang is targeting as many as 50,000 certificates to be registered with a total of 55,000 land parcels so that with a high quantity output, many problems will occur and a strategy is needed to solve it. Based on these problems, it is necessary to study related problems and the completion of the Semarang City PTSL Program 2021. The research was carried out using a juridical approach by obtaining the results of research in the field. Especially in the area of ​​Bendan Duwur and Sampangan urban villages, Semarang City in implementing the PTSL program in 2021 in the City of Semarang. Through this research, the obstacles to implementing PTSL Semarang City 2021 lie in the implementation of socialization, data collection and asset registration as well as in digitizing PTSL data. The settlement strategy that can be taken to minimize the problems of implementing PTSL is by improving resource strategies, coordinating with villages / sub-districts in making a Physical Land Acquisition Statement, as well as educating the public regarding online data that has been undertaken to support conversion from analog data to data. digital.
Socio-Economic and Legal Analysis on Forest Protection
Authors: Sanjaya Andika Bangun
Published: December 2021

The protection of forests today is not just a problem is regional (national) but it is a world problem (global). This is related to the function of forests in maintaining ecological balance which also affects the global climate, such as the effect of 'global warming' which can threaten the safety of living things. Nevertheless, reality shows that the economic function of the forest, ie as a source of the eye livelihood for a group of people, as a means of accumulation capital (capital) for entrepreneurs (capitalist), and as a source of foreign exchange for countries, often defeating forest functions in maintaining equilibrium ecological (including global climate). The continued pressure of population increased is one of the factors that contribute to accelerating forest destruction. This is due to the need for more land and more building materials, both for settlement and land for activities farming, and materials for new buildings. Utilization excessive forest economic functions by a human (forest exploitation) without caring about ecological balance can be catastrophic for humans themselves, and require far-reaching economic and social costs greater than the economic results that have been obtained.
Special Autonomy of Yogyakarta in the Context of Local Autonomy Law
Authors: Sidiq Muhamad Abdulah
Published: December 2021

Local government is the authority of the autonomous regions to organize and manage the interests of local people according to their own initiative based on community aspirations in accordance with the laws and regulations. In response to the demands of government reform quite quickly, it has undertaken a sufficiently fundamental breakthrough of the various laws in the political field from the centralist-autoritarian to the autonomous-democratic. After successfully compiling the three laws on the political field that became the basis of the election in 1999 the government immediately followed him with a new law in the field of special politics on power relations between the central and local, namely Law no. 22 of 1999 on Regional Government and Law No. 25 of 1999 on Financial Relations between Central and Regional. The formation of regions is basically intended to improve public services in order to accelerate the realization of community welfare as well as political education at the local level. Considerations and other conditions that enable the area to organize and realize the purpose of the establishment of the region and the granting of regional autonomy. The Government may designate special areas in the autonomous regions to carry out specific government functions that are specific to national and / or national-scale interests "special" for the interests and benefit of Indonesia. One of these special autonomous regions is the Special Region of Yogyakarta that has been recognized special autonomous region in Law No.13 of 2012 on the privilege of Yogyakarta.
Developing Academic Writing Skills in EFL University Students Through Haiku Composition
Authors: Santillán-Iñiguez Juan José , Rodas-Pacheco Fabián Darío
Published: December 2021

Background. Although there is empirical evidence to support the inclusion of poetry in the EFL classroom, the medium is rarely encountered in language learning environments. Aims. This study aimed to determine the influence of haiku composition tasks on developing academic writing skills of a group of TEFL majors at an Ecuadorian university. Method. The study was part of a larger research project (originally presented as a Master’s degree dissertation), developed under a mixed-method approach. This article reports the quantitative findings of the statistical analysis of results of two essay-based tests, administered before and after a six-week treatment that promoted haiku composition practices. Results. The findings determine a positive influence of haiku composition on the development of the academic writing skills of the participants in the study. Discussion. The main benefits of haiku composition in terms of academic writing skill development relate to the vocabulary enrichment and enhancement of linguistic competence, audience awareness, and writing process consciousness. These benefits are linked to the formal meter and reader-centeredness nature of haiku. The results encourage the inclusion of poetry-based creative writing tasks in EFL contexts; the evidence suggests that these activities are feasible and beneficial for motivated learners, particularly when framed within a student-centered process.
Gamificación, motivación y rendimiento en educación: Una revisión sistemática
Authors: Prieto-Andreu Joel Manuel , Gómez-Escalonilla-Torrijos Juan Diego , Said-Hung Elías
Published: December 2021

Introducción. El propósito de este artículo es revisar la bibliografía que analiza la relación entre gamificación, motivación y aprendizaje y, así, proporcionar ideas pedagógicas y didácticas para su implementación en la educación no universitaria. Metodología. Se realiza una metodología mixta, en la que se analiza una muestra intencional conformada por 37 artículos, escogidos intencionalmente siguiendo los estándares de evaluación de la American Educational Research Association (AERA, 2006), de un total de 1 706 estudios, publicados en ISI Web Of Science. Resultados. Se seleccionaron y analizaron 37 estudios escogidos intencionalmente siguiendo los estándares de evaluación de la AERA (2006), y se constata que la gamificación tiene una repercusión directa y positiva sobre las experiencias del alumnado en cuanto a su motivación y rendimiento. Discusión. El trabajo apunta a que la gamificación está siendo abordada académicamente desde dos perspectivas: como metodología orientada a la motivación del alumnado en su aprendizaje competencial; y como forma de potenciar el rendimiento académico en las diferentes áreas del conocimiento.
Language Teaching Methods: There is Nothing New Under the Sun, or Is There?
Authors: Zúñiga Vargas Juan Pablo
Published: December 2021

This essay intends to problematize the possible direction that the field of language teaching will follow in the XXI century. For this purpose, nine methodological parameters for conceptualizing every language teaching method will be described, the impossibility of designating the best method will be considered, the concept of the post method condition and its ten macro strategies for language teaching will be discussed along with the challenges for its implementation, a minimalist proposal for language teaching will be referred to, and the current phenomenon of textbook-defined practice will be analyzed.
Narrativas sagradas: autobiografías espirituales de mujeres como práctica intercultural
Authors: Cheuquenao Aillapan Rosa Persida , Castillo Muñoz Andrea De Lourdes
Published: December 2021

Se analizó el reconocimiento de la espiritualidad de las mujeres como un ámbito de negación y como un ejercicio que permitiría un diálogo interespiritual a través de las autobiografías de las autoras. A partir de antecedentes sobre el reconocimiento de la espiritualidad de las mujeres, se realizó una investigación cualitativa con diseño biográfico narrativo. Los resultados evidenciaron que el reconocimiento de dicha espiritualidad forma parte de una interculturalidad crítica y decolonial, así como que la autobiografía espiritual sería un instrumento de diálogo entre espiritualidades. Se concluye que la espiritualidad de la intemperie posibilitaría el proceso de reconocimiento intercultural.
Pseudo Jahn−Teller Origin of the Proton Tunneling in Zundel Cation Containing Water Clusters
Authors: Geru I. , Gorinchoy N. , Balan I.
Published: December 2021

The pseudo Jahn–Teller (PJT) origin of the proton transfer barrier in the Zundel cation at different O–O distances and in an H5O2+(H2O)4 cluster is revealed by means of  ab initio calculations of their electronic structures and the adiabatic potential energy curves. The vibronic constants in this approach were estimated by fitting the ab initio calculated adiabatic potential to its analytical expression. It is shown also that the high-symmetry nuclear configurations ofproton-centered water clusters of the type H+(H2O)n (n = 6, 4, 3) are unstable with respect to the low-symmetry nuclear distortions leading to forming the dihydronium cation H5O2+ and the appropriate number of water molecules: H2n + 1On+ →  (n – 2)H2O + H5O2+. The reason for this instability and the subsequent decay is the PJT coupling between the ground and excited electronic states.
Comparative Analysis of Standard ΛCDM and ΛCS Models
Authors: Kuzmichev V.E. , Kuzmichev V.V.
Published: December 2021

We draw a comparison of time-dependent cosmological parameters calculated in the standard ΛCDM model with those of the model of a homogeneous and isotropic Universe with non-zero cosmological constant filled with a perfect gas of low-velocity cosmic strings (ΛCS model). It is shown that pressure-free matter can obtain the properties of a gas of low-velocity cosmic strings in the epoch, when the global geometry and the total amount of matter in the Universe as a whole obey an additional constraint. This constraint follows from the quantum geometrodynamical approach in the semiclassical approximation. In terms of general relativity, its effective contribution to the field equations can be linked to the time evolution of the equation of state of matter caused by the processes of redistribution of the energy between matter components. In the present article, the exact solutions of the Einstein equations for the ΛCS model are found. It is demonstrated that this model is equivalent to the open de Sitter model. After the scale transformation of the time variable of the ΛCS model, the standard ΛCDM and ΛCS models provide the equivalent descriptions of cosmological parameters as functions of time at equal values of the cosmological constant. The exception is the behavior of the deceleration parameter in the early Universe.