bluuebunny/crossref_metadata_2025 huggingface dataset:
Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction
Authors: Kumar Kaushlendra , S Krishnapriya , Ebenezer Anupriya , Kalaiah Mohan Kumar , D Deviprasad
Published: September 2022

Background: Among individuals with vestibular dysfunction, the loss of vestibular sensory information is found to alter cognitive abilities that coordinate spatial and non-spatial information. P300 is an event-related potential commonly used to assess cognitive processing. The aim of the present study was to compare the latency and amplitude of cortical auditory evoked potential and P300 between individuals with vestibular dysfunction and individuals with no vestibular dysfunction.

Methods: Forty adults with a mean age of 40.5 ± 13.07 participated in the study. Group I included 20 adults diagnosed with vestibular dysfunction and group II included 20 age-matched adults with no vestibular dysfunction. The P300 was recorded from the electrode site Cz and Pz. It was elicited using pure-tones in odd-ball paradigm. The latency and amplitude of peaks P1, N1, P2, and N2 of the cortical auditory evoked potential and the P300 were measured.

Results: Significant amplitude difference was observed in cortical potentials at Cz and Pz. The P300 was present only in 70% of individuals with vestibular dysfunction compared to 100% among individuals with no vestibular dysfunction. The mean amplitude of the P300 was slightly larger in group 1 compared to group 2 and the mean latency of the P300 was similar in both groups. However, the difference in amplitude of the P300 between groups was not statistically significant.

Conclusions: Knowing the cognitive function of individuals with vestibular dysfunction enables planning vestibular rehabilitation therapy, which enhances the quality of life in these individuals by improving their vestibular and cognitive functions.
Modified solid in oil nanodispersion containing vemurafenib-lipid complex-in vitro/in vivo study
Authors: Almajidi Yasir Q. , Maraie Nidhal K. , Raauf Ayad M. R.
Published: September 2022

Background: Vemurafenib (VEM) was a licensed drug for the treatment of skin melanoma and is available only in the market as oral tablets prescribed in huge doses (1920 mg/day). One reason for the high dose is vemurafenib's low oral bioavailability.

Methods: VEM-lipid complex (DLC) was predicted based on Conquest and Mercury programs and prepared using the solvent evaporation method using the lipid (phosphatidylethanolamine). DLC was subjected to characterization (FT-IR, Raman spectroscopy, DSC, TGA, P-XRD, and FESEM) to confirm complexation.  DLC was used to prepare solid in oil nanodispersion (DLC-SON) and subjected to in vitro, ex vivo, and in vivo evaluation in comparison to our recently prepared conventional SON (VEM-SON) and DLC-control.

Results: Conquest and Mercury predict the availability of intermolecular hydrogen bonding between VEM and phosphatidylethanolamine (PE). All characterization tests of DLC ensure the complexation of the drug with PE. Ex vivo studies showed that the drug in DLC-SON has significantly (P<0.05) higher skin permeation than DLC-control but lower drug permeation than conventional SON but it has a higher % skin deposition (P<0.05) than others. The half-maximal inhibitory concentration (IC50) of the prepared DLC-SON is significantly high (P<0.05) in comparison to the conventional SON and pure VEM. In vivo permeation using confocal laser scanning microscopy (on the rat) results indicated that both conventional SON and DLC-SON can cross the SC and infiltrate the dermis and epidermis but DLC-SON has a higher luminance/gray value after 24 h in the dermis in comparison to the conventional SON.

Conclusion: The novel lipid complex for VEM prepared using PE as a lipid and enclosed in SON showed higher anticancer activity and topical permeation as well as sustained delivery and good retention time in the dermis that localize the drug in a sufficient concentration to eliminate early diagnosed skin melanoma.
HLA class I and discoveries of the HLA-K (pseudogene) related to disease severity and progression in patients with spondyloarthritis in Dr. Soetomo General Hospital, a tertiary health care center in Surabaya, Indonesia
Authors: . Yuliasih , Nisa' Nabilatun , Rahmawati Lita Diah , Prastayudha Cahaya
Published: September 2022

Background: Spondyloarthritis (SpA) is a chronic inflammatory disease characterized by enthesitis, sacroiliitis, and axial joint involvement. Although the association of HLA with SpA has been widely reported, there have been no studies of HLA type in the Indonesian population within the last 20 years. This study aims to identify the HLA type in SpA patients at Dr. Soetomo General Hospital, Indonesia.

Methods: This study used a cross-sectional analytical design with samples that met the criteria for SpA according to the 2009 ASAS. The clinical scores used in this study were mSASSS, BASFI, ASDAS, and Schober. Genetic identification using PCR was performed followed by sanger sequencing to determine the HLA type in the patient. DNA sequences were aligned with BLAST, and a phylogenetic tree was created using MEGA 11. Descriptive and comparative analyzes were performed using GraphPad Prism 9.

Results: This study founded four types of HLA in SpA patients at Dr. Soetomo General Hospital, that is HLA-B with six alleles; -B*2704 (12.86%), -B*2705 (1.43%), -B*2706 (1.43%), -B*1802 (4.28%), -B*57v (1.43%), -B*35 (2.86%), HLA - C (21.43%), and HLA - K (52.83%). Clinical scoring of HLA-C and HLA-K indicated severe and progressive disease activity. The HLA-K had the highest mSASSS (26, 95% CI: 22–28), while HLA-C had the highest BASFI score (60, 95% CI: 55–68), the lowest Schober score (12, 95% CI: 10–14), and the shortest duration of illness (22, 95% CI: 12–36). There is no significant difference in the ASDAS score among types.

Conclusions: The most common HLA types found in SpA patients at Dr. Soetomo were HLA-C and HLA-K, with the most progressive disease activity indicated by poor mSASSS, BASFI, ASDAS, and Schober scores with a short duration of illness.
The coronavirus disease 2019 (COVID-19) pandemic in nursing homes – the experience of care workers in Poland
Authors: Necel Ryszard
Published: September 2022

Background: Nursing homes in Poland are the most common formal care institutions for dependent people. During the coronavirus disease 2019 (COVID-19) pandemic, nursing homes had particularly high infection rates. In this context, it is important to ask about the experiences of the care workers working in these institutions.

Methods: This research was conducted using the computer-assisted web interviewing (CAWI) technique in five provinces in Poland. The field research was carried out in April 2021. The research sample included, among others, nurses, care workers, therapists, social workers and the management staff of institutions whose representatives worked during the COVID-19 pandemic. Respondents were asked to assess the care provided to residents.

Results: It turned out that the vast majority of respondents positively assessed the fulfillment of the basic living needs of residents and the availability of care. The assessment of the organization of residents’ leisure time, the fulfillment of their religious and cultural needs, and the issue of maintaining contacts with the social environment was less satisfactory. The article also describes the results of care institution employees’ self-assessment of their mental health. For the majority, the most stressful factor was the need to work in a health-threatening environment and the sense of responsibility for the residents. Regarding the availability of the forms of support offered to workers experiencing deteriorating mental health due to working in the pandemic situation, more than a third said that their institution did not offer any form of assistance.

Conclusions: The article lists a number of recommendations. In the light of the data obtained, it is necessary to increase the intensity of services provided to residents of nursing homes in terms of organizing their free time, meeting their religious and cultural needs and maintaining contact with the social environment.
cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma
Authors: Tripathi Shashwat , Najem Hinda , Mahajan Akanksha Sanjay , Zhang Peng , Low Justin T , Stegh Alexander H , Curran Michael A , Ashley David M , James Charles David , Heimberger Amy B
Published: September 2022

Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon genes (STING) is an important activator of immune response and results in production of Type 1 interferon and antigen presentation by myeloid cells. This review will discuss important developments in STING agonists, potential biomarkers for STING response, and new combinatorial therapeutic approaches in gliomas.
Gut Microbiome as a Novel Treatment Strategy for Psoriasis
Authors: Zając Marlena , Borowiecka Monika , Gruca Dariusz , Buksak Dagmara , Wróblewski Wiktor
Published: September 2022

Introduction and purpose: Psoriasis is a skin disease that develops following chronic inflammatory signaling and keratinocyte hyperproliferation. The pathogenesis of psoriasis is compound and not yet fully understood. Several studies concerning gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. This study aims to highlight the latest scientific evidence regarding the gut microbiome alterations of psoriatic patients, as well as the state of knowledge in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis.

Brief description of the state of knowledge: The current state of knowledge indicates that the main causes of psoriasis may be a genetic predisposition, as well as many immunological and environmental factors, including dysbiosis of the intestinal microflora. The article covers clinical and experimental studies which indicate that gut microbiota dysbiosis concerning diversity as well as the composition of the microbiome is the potential causal factor of psoriasis and the gut microbiota may serve as a promising prevention/therapy target for psoriasis patients.

Conclusions: This review highlighted a strong link between psoriasis and the gut microbiota, to add new knowledge for discovering the relationship between the altered intestinal microbiota in psoriasis patients. Despite all of these interesting findings, there are a lot of limitations and challenges that future studies should face. More precise and greater studies need to be done to fully understand the potential of microbiota-aimed therapies.
The use of metformin in the treatment of Intrahepatic cholestasis of pregnancy
Authors: Pawłowska Paulina , Ozga-Stachurska Alicja , Wójcik-Grudzień Justyna , Rozenbajgier Martyna
Published: September 2022

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disease. It is characterized by persistent pruritus, usually occurring after 30 weeks of pregnancy, and by elevated levels of bile acids and transaminases, which decrease over the course of 2-3 weeks postpartum. [1,2]The occurrence of ICP in the mother may be associated with significant complications in the fetus, such as: preterm labor, intrauterine asphyxia, or sudden fetal death. Currently, the treatment of choice is ursodeoxycholic acid (UDCA).[2,6] Recently, it was observed that the administration of metformin in cases not responding to standard therapy improved lipid disorders in pregnant women.

 

The aim of the study:  The aim of the study is to present the possibility of using metformin in the treatment of ICP in pregnant women not responding to standard treatment and to present a clinical case..

Material and methods: The work is a review of the literature on the management of ICP and the use of metformin in the treatment of lipid metabolism disorders, as well as a brief case report of a patient with  intrahepatic cholestasis of pregnancy.

Description of the state of knowledge: Metformin is an oral antidiabetic drug belonging to the group of biguanides. However, the latest observations show that metformin also has a beneficial effect on the liver function and on the lipid metabolism in pregnant women. In these patients, the levels of bile acids and liver enzymes decreased after the use of metformin.

Summary: The mechanism of action of metformin explaining its beneficial effect on the lipid metabolism in pregnant women with intrahepatic cholestasis is not fully understood.
Presolving for Mixed-Integer Semidefinite Optimization
Authors: Matter Frederic , Pfetsch Marc E.
Published: September 2022

This paper provides a discussion and evaluation of presolving methods for mixed-integer semidefinite programs. We generalize methods from the mixed-integer linear case and introduce new methods that depend on the semidefinite condition. The methods considered include adding linear constraints, deriving bounds relying on 2 × 2 minors of the semidefinite constraints, tightening of variable bounds based on solving a semidefinite program with one variable, and scaling of the matrices in the semidefinite constraints. Tightening the bounds of variables can also be used in a node presolving step. Along the way, we discuss how to solve semidefinite programs with one variable using a semismooth Newton method and the convergence of iteratively applying bound tightening. We then provide an extensive computational comparison of the different presolving methods, demonstrating their effectiveness with an improvement in running time of about 22% on average. The impact depends on the instance type and varies across the methods.

Funding: This work was supported by the EXPRESS II project within the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) priority program CoSIP (DFG-SPP 1798). It was also partly supported by the DFG within Project A4 in the SFB 805.
Sokağın Sesi Sahnede; Parade Balesinde Erik Satie’nin Müzik Anlayışı
Authors: BİRGÜL AKÇAKMAK Hale
Published: September 2022

Erik Satie 20.yy’ın başında Paris merkezli yeni sanat hareketleri ile ilişkisi bakımından ayrıcalıklı yere sahiptir. Avangart sanat sahnesinde Cocteau, Picasso, Max Jakop ve Picabia gibi önemli isimlerle yaptığı çalışmalar dönemin önemli sanat hareketleri ile olan organik bağını ortaya koyar. Parade balesi yüzyıl başındaki yenilikçi arayışları temsil eden başlıca sahne eserinden biridir. Satie’nin erken dönemlerinden itibaren sergilediği Avrupa müzik geleneğinden bağımsız tavrı 20.yy’ın ikinci yarısından itibaren John Cage, Morton Feldman gibi öncü besteciler tarafından tekrardan ele alınmıştır. Müzik tarihinde Avrupa müziği geleneği karşısında radikal bakış sergileyen erken figürlerden biri olarak karşımıza çıkar. Bu makalede Parade’in müzik ve ses malzemesi farklı sanat hareketleri ilişkisi bakımından ele alınacak, bahsi geçen dönem bağlamındaki önemi araştırılacaktır.
AN EVALUATION ABOUT IMPLEMENTATION WHICH IS AT THE CENTRE OF GROOM AMONG THE WEDDING CUSTOMS: AN EXAMPLE OF BANDIRMA
Authors: KABAY İrem
Published: September 2022

İnsan hayatı boyunca üç önemli dönem ile karşılaşmaktadır. Bu dönemler; doğum, evlenme ve ölümdür. Her biri kendi içerisinde birçok basamaklara ayrılmaktadır. Bu çalışma ise Türk evlenme kültüründe damat merkezli gelenekleri ele almayı hedeflemiş, Balıkesir ili Bandırma ilçesinde damat merkezli pratikler üzerinde durmuştur. Evlilik üzerine yapılan çalışmalar ve Bandırmada yapılan mülakatlar çerçevesinde düğün öncesi ve sonrasında gerçekleşen ritüel ve uygulamalarda, damada karşı geliştirdikleri pratikleri ve uygulamaları tespit etmektedir. Evlenme, kadınla erkeğin aile kurmak için yasalarca birleşmesine verilen addır. İki cinsiyetin(kadın-erkek) bir araya gelmesi toplumun sosyal, ekonomik, dinî, etnik kabulleri ile yaşanılan topluma ait ritüellerin gerçekleşmesi ile meşru bir hâle gelmektedir. Kadın ve erkeğin evlenmesi statü ve rol bağlamında hem çiftler hem de aileleri için önem arz etmektedir. Araştırmada doküman analizi, sahada derleme yöntemi ve mülakat tekniği kullanılmıştır. Yapılan taramalar sonucunda damat, bölgelere göre değişiklik göstererek uygulamalarda pasif ya da aktif olarak rol oynamaktadır. Çoğunlukla ataerkil bir düşünceye sahip olan Türk kültürü sıklıkla düğün geleneklerinde damadı merkez haline getirmektedir.
The Other Side of the Mirror: Welfare State in Swedish Director Lukas Moodysson's Lilya 4-ever (2002)
Authors: DEMOĞLU Meliha Elif , YAMANTELLİ Umut
Published: September 2022

Lukas Moodysson is one of the leading directors in contemporary Swedih cinema. He shot his first feature film in 1998 and his last film in 2013. Totally he has eight films. He is also scriptwriter in his all films and sometimes also the pruucer. He made films which influences from his own society, thmes he experienced and themes he cared. Minimalist style, natural acting are seen in the films of the director. He has created a unique style that frequently includes child actors, focuses on human relations in his own society, and deals with growing pains and social problems. Director’s most important film is Lilya 4-ever(2002). The importance of this film is because of its harsh criticism about both Swedish society and Europe in general about human trafficking and forcing young girls into prostitution. In this study, the film will examine the appearance of the welfare society and the effect of the film on society with the sociological analysis method. As a result, the social criticism of the film led the Swedish authorities to take action within the framework of the problem, and showed the power of cinema on society.
MATLA-I SA’DEYN VE MECMA-I BAHREYN ADLI ESERİN İKİNCİ CİLT BİRİNCİ BÖLÜMÜNÜN TANITIMI, YAZAR; KEMÂLEDDÎN ABDÜRREZZÂK SEMERKANDÎ, MİLLİ EĞİTİM MÜDÜRLÜĞÜ İNCELEMELER VE ARAŞTIRMALAR KURUMU MATLA-I SA’DEYN AND MECMA-I BAHRAIN INTRODUCTION FIRST PART OF THE SECOND VOLUME OF THE NAMED WORK, AUTHOR; KEMÂLEDDÎN ABDÜRREZZÂK SEMERKANDÎ, DIRECTORATE OF NATIONAL EDUCATION, RESEARCH AND RESEARCH INSTITUTION
Authors: AKÇAY Filiz
Published: September 2022

Giriş

Bilindiği üzere Orta Çağ tarihi ile ilgili çalışmalar yapmak kaynakların özellikle Farsça ve Arapça gibi farklı dillerde olması nedeniyle oldukça meşakkatlidir. Bu bakımdan elde bulunan mevcut kaynaklar ile ilgili yapılan her bir çalışmaların kıymeti büyüktür. İncelememize konu olan Maṭla-ı Sa’deyn ve Mecma-ı Baḥreyn adlı eser de Farsça olarak yazılmış ve günümüze ulaşmış eserler arasında yer almaktadır. Adı geçen eser özellikle Hindistan’ın o zamanki durumu ve oradaki Türkler’in tarihi bakımından büyük önem taşımaktadır. Ayrıca dönemin siyasi yapısı ve devletlerarası ilişkilerin anlaşılması açısından kıymetli bir konumdadır. Dönemin güçlü hükümdarları, etkin siyasi karakterli hakkında eserde detaylı bilgilerin oldukça geniş yer alması bu alanda çalışma yapacak tarihçilere eşi bulunmaz bir bilgi kaynağı sunacak niteliktedir. Eserde dönemin güçlü devlet adamları ve Melikliklerin hâkimiyet mücadeleleri de eserde ele alınan konular arasındadır. Nitekim geniş bir yelpaze ile ele alınan konuların Türkçe olarak başlıklar halinde araştırmacılara sunulması önemli bir husustur. Bu bakımdan eseri tanıtmak ve içeriğine Türkçe ulaşılmasını sağlamak için çeviri yaparak incelenmesini kolaylaştırma gayretinde bulunduk. Eser toplam iki cilt ve dört kısımdan oluşmaktadır. Tanıtımını yaptığımız İkinci cilt Muhammed Şefîat tarafından 1936’da Lahor’da yayınlanmış, ardından Abdü’l Hüseyin Nevâi Bedân tarafından açıklamalar ve düzeltmeler eklenmiştir. Daha önce tarafımızdan tanıtımı yapılan birinci cilt birinci kısımda yazar ve eser ile ilgili bilgilere yer verildiğinden bu cildin tanıtımı yapılırken tekrar olmaması açısından aynı konulara yer verilmemiştir.
ON THE VERGE OF ANOTHER PRIVACY: INTERİOR SPACE PROBLEM IN MASS HOUSING
Authors: AVCI Neslihan
Published: September 2022

While the industrialization process, which started in the 1950s in Turkey and accelerated with the development of transportation vehicles and technology, caused migration from rural to urban areas, it also made the first manifestations of irregular urbanization visible. The folklore practices acquired by the Turkish people, who came from the nomadic equestrian culture, under difficult living conditions, have been continued by maintaining a life in between in today's unsuitable residential architecture. Turkish people, who attach importance to privacy, have also opened the door to search for new solutions by building walls on their own understanding of life on the threshold of another privacy. In this article, it has been examined how the disappearing symbols, neighborhood relations, and the understanding of life integrated with nature have undergone a transformation in the transition from traditional Turkish houses, which have deep meanings related to Turkish life philosophy, to mass housing. In this context, it is aimed to convey the problems encountered in mass housing in the language of women with a total of 19 resource people in the sample of Istanbul, where the phenomenon of urbanization is the most intense. The research was carried out by interview and observation method, and sound recording were obtained. As a result of the findings obtained in the research, it was concluded that the standard architecture in mass housing could not connect with the Turkish philosophy of life and could not adequately respond to daily needs.
ESKİŞEHİR’DE BİR SAĞALTMA OCAĞI: ALBASTI
Authors: BÜYÜKOKUTAN TÖRET Asli , ÖZDEMİR Tuğçe
Published: September 2022

Lohusa ve yeni doğan bebeğe musallat olmasıyla bilinen “albastı”, kötü ruhlu dişi bir ruh tasarımıdır. Türk topluluklarında yaygın olarak bilinen bu şerir ruhun vereceği zarardan korunmak adına bazı inanış ve uygulamalar bulunmaktadır. Bunlar arasında halk hekimliğine bağlı tedavi ve korunma yöntemleri olmakla birlikte ocağa müracaat etme de vardır. Ahır, samanlık, viranelik, ıssız yer ve su kaynaklarında barınan, lohusanın ve bebeğinin ciğerini söküp götürmesinden korkulan bu tehlikeli varlığı yakalayan kişi onu, kendi soyundan kimseye zarar vermemesi şartıyla bırakır ve buna karşılık albastı ocağı olur. Albastı inancı, ocaklık geleneği ile soydan taşınarak bugüne kadar ulaşmıştır. Makalede, Eskişehir merkez ilçeye bağlı Yahnikapan mahallesinde hizmet veren Albastı ocağı üzerinde durulmuştur. Taliplerini on iki imamdan güç alarak yaptığı uygulamalarla tedavi etmekte olduğunu belirten ocak, Horasan’dan gelen Alevi Türkmen aşiretlerine dayanmaktadır. Çalışmanın verileri, 2020-2022 yılları arasında bilimsel araştırma projesi kapsamında gerçekleştirilen saha araştırmasına dayanmaktadır. Albastı ocağından derinlemesine mülakat ve gözlem teknikleriyle elde edilen malzeme esas alınmıştır. Yapılan değerlendirmede ocağın, sağaltma ocağı olarak aktif bir şekilde hizmet vermeye devam ettiği görülmüştür. Günümüzde birçok ocağın, yeni nesil tarafından sürdürülmek istenmemesi ve ocaklıların il merkezine taşınması nedeniyle kapandığı göz önünde bulundurulduğunda Albastı ocağı, kent toplumunda kültürel belleğin sürekliliği açısından önemli bir işlevi yerine getirmektedir.
KIR KÖKENLİ ÇALIŞMALARDAN KENT MERKEZLİ ÇALIŞMALARA: KENTLEŞME ODAĞINDA TÜRKİYE’DE FOLKLORUN GELİŞİMİ ÜZERİNE BİR DENEME
Authors: YILMAZ Onur
Published: September 2022

Kuruluşunun 100. yılını kutlayacağımız Türkiye Cumhuriyeti, geride kalan yüz yıllık dönemde gerek kendi bünyesindeki gerekse de dünyadaki gelişmelere bağlı olarak siyasal, ekonomik, toplumsal ve kültürel değişimler geçirerek gelişimini sürdürmüştür. Bu gelişmeleri en çok etkileyen olgulardan biri olan göç ve kentleşme, sosyal bilimlerin üzerinde en çok yoğunlaştığı konuların başında gelmektedir. Türkiye’de göçlerle şekillenen kent kültürü, farklı zaman dilimleri içerisinde farklı özellikler meydana getirmiştir. Dünyadaki gelişmelerden tamamen bağımsız olmayan göç olgusunun nedenleri ve sonuçları benzer görünümler ortaya çıkarsa da Türkiye’nin kentleşme deneyimi büyük oranda kendine has bir süreç izlemiştir. Çok partili siyasal sisteme geçtiğimiz 1950’li yıllarda tarımsal alanda meydana gelen makineleşme neticesinde kırsalda atıl bir iş gücü ortaya çıkmıştır. Bu iş gücünün kentlere yönelmesiyle Türkiye’de kentleşme süreci başlamıştır. Bu süreç 1980’li yıllardan itibaren küreselleşme ve neoliberal ekonomiye geçişle birlikte farklı boyutlar kazanmaya başlamıştır. Bilimsel alanlar da bu değişim süreçlerinden etkilenerek çalışma konularını zaman içerisinde belirli başlıklara yoğunlaştırmıştır. Bu makalede halkbiliminin Türkiye’deki gelişimi, siyasi ve ekonomik koşullar da göz önünde bulundurularak kentleşme sürecine odaklanmakta ve kent bilimi olan sosyolojinin gelişimiyle karşılaştırmalı bir şekilde ele alınmaktadır. Ayrıca süreç içerisinde değişen paradigmalar çerçevesinde bugünkü duruma yönelik saptamalar da eleştirel bir bakış açısıyla değerlendirilmektedir.
KOKOŞNİK: GELENEK, TILSIM VE TOPLUMSAL CİNSİYET ROLLERİ ÜÇGENİNDE BIR KADIN BAŞLIĞI
Authors: ÖZAKIN Duygu
Published: September 2022

Folk costumes, which are among the elements of material culture and concrete indicators of the lifestyle of individuals, carry the reflections of the life shaping beliefs from generation to generation. Because of these aspects, they are the target of Westernization movements while being embraced by a certain group as a symbol of national values. Kokoshnik, a traditional headdress worn by women, goes through a similar transformation process from the time it is first used to the date when it is pushed out of daily life due to ideological concerns. The headdress is named after the Old East Slavic word kokosh meaning “chicken”, because of its form similar to that of poultry’s comb. The tailors with specialized training in sewing this flamboyant headdress adorned with precious stones and embroidery, called kokoshnitsa, which also comes from the same root. In this review article, it is aimed to contribute to the international literature, which has been determined to be quite limited in terms of content and quantity. Studies that deal with kokoshniks both as a traditional headdress and an indicator of women’s marital status and social position, are evaluated through comparative method. This study, which compares the etymological studies of Russian ethnographers, folklorists, art critics, and linguists such as G. S. Maslova, N. I. Gagen-Torn, D. K. Zelenin, V. V. Stasov, V. I. Dal’ and S. I. Ojegov on kokoshnik, also includes current research. In all these studies, it is revealed that two basic tendencies gain importance: In early studies, the emergence of the headdress due to the religious superstition about uncovered hair brings bad luck is discussed and its function as a talisman is emphasized. The values symbolized by kokoshnik in the social status of women and in distribution of responsibilities within the family are also examined in the light of ethnographic data. However, in current studies, a critical perspective draws attention that the kokoshnik is reflected as an accessory that symbolizes traditional costumes in a stereotypical way, and thus, the Russian clothing culture, which has a very rich history indeed, is reduced to a monotonic image.
Afrikalı Göçmenlerin Hikayesini Belirleyen Etkenler ve İletişimin Rolü
Authors: GENEL Zeynep
Published: September 2022

Göç hareketliliği günümüz dünyasının en çok tartışılan konularının başında gelmektedir. Dünya genelindeki bu hareketlilik küresel ölçekte hedeflenen sürdürülebilir kalkınma hedeflerinden 10.7 eşitsizliklerin azaltılması ve düzenli göç için mücadele olarak yer almaktadır. Göç olgusunun oluşmasında ve yaşanmasında itici ve çekici faktörlerin ve bu faktörlerin oluşumunda iletişimin rolünün anlaşılması için kamu politikaları yapıcılara veri sağlanması ulusal düzeyde 11.Kalkınma Planı hedefleri arasındadır. Bu doğrultuda, bu çalışmanın amacı küresel ve ulusal düzeyde sağlıklı kamusal iletişim stratejileri geliştirilebilmesi için alana ve uygulayıcılara katkıda bulunmaktır. Bu amaçla, Sahra- Altı Afrika ülkelerinden Türkiye’ye göç etmiş kişilerle 2022 yılında İstanbul ve Konya’da 10 Afrikalı göçmen ile nitel bir araştırma gerçekleştirilmiştir. Daha iyi bir yaşam, iklim ve coğrafi zorlukların kaynak ülkeden göç etmeye yol açan itici faktörleri oluştururken, iletişim platformlarından edinilen bilgi ve göç etmiş kişilere ait hikayelerin ise çekici faktörleri yarattığı anlaşılmıştır.
Anti-inflammatory Effects of Myrrh Ethanol Extract on Particulate Matter-induced Skin Injury
Authors: Jung Young Hee , Roh Yeun Wha , Chong Myongsoo
Published: September 2022

Objectives: Myrrh have been used as a traditional remedy to treat infectious and inflammatory diseases. However, it is largely unknown whether myrrh ethanol extract could exhibit the inhibitory activities against particulate matter (PM)-induced skin injury on human keratinocytes, HaCaT cells. Therefore, this study was aimed to investigate the inhibitory activity of myrrh ethanol extract on PM-induced skin injury in HaCaT cells.Methods: To investigate the inhibitory effects of myrrh ethanol extract in HaCaT cells, the skin injury model of HaCaT cells was established under PM treatment. HaCaT keratinocyte cells were pre-treated with myrrh ethanol extract for 1 h, and then stimulated with PM. Then, the cells were harvested to measure the cell viability, reactive oxygen species (ROS), pro-inflammatory cytokines including interleukin (IL) 1-beta, IL-6, and tumor necrosis factor (TNF)-α, hyaluronidase, collagen, MMPs. In addition, we examined the mitogen activated protein kinases (MAPKs) and inhibitory kappa B alpha (Iκ-Bα) as inhibitory mechanisms of myrrh ethanol extract.Results: The treatment of myrrh ethanol extract inhibited the PM-induced cell death and ROS production in HaCaT cells. In addition, myrrh ethanol extract treatment inhibited the PM-induced elevation of IL-1beta, IL-6, and TNF-α. Also, myrrh ethanol extract treatment inhibited the increase of hyaluronidase, MMP and decrease of collagen. Furthermore, myrrh ethanol extract treatment inhibited the activation of MAPKs and the degradation of Iκ-Bα.Conclusions: Our result suggest that treatment of myrrh ethanol extract could inhibit the PM-induced skin injury via deactivation of MAPKs and nuclear factor (NF)-κB in HaCaT cells. This study could suggest that myrrh ethanol extract could be a beneficial agent to prevent skin damage or inflammation.
The Retrospective Study of Advanced Cancer Patients Receiving Integrative Cancer Treatments in single Comprehensive and Integrative Medicine Hospital
Authors: Joo Jeonghyun , Chon Songha , Sohn Kicheul , Lee Sanghun
Published: September 2022

Objectives: Traditional Korean medicine (TKM) has been supplied as part of a national health care system in South Korea under a dual medical system, however it has been difficult to mix western medicine and TKM medical practices in existing hospitals. For the objective of innovative integration between them, Comprehensive and Integrative Medicine Hospital were founded in Daegu, South Korea. Here, we discussed the clinical outcomes of cancer patients who received integrative cancer treatment (ICT).Methods: A total of 678 patients previously diagnosed with cancer were retrospectively checked in our institution for 2 years. After applying inclusion/exclusion criteria, 573 patients were eligible for the final analysis. The overall survival (OS) of these patients in the aftercare period were determined. We looked at how clinical factors and treatments including chemotherapy, complementary and alternative medicine (CAM), and TKM affected the OS.Results: At the first visit, 212 subjects had no evidence of disease after tumor resection and 355 ones with advanced cancer, who receiving ICT including chemotherapy, CAM, and TKM showed better OS compared to the CAM including TKM or the best supportive care (median OS = 216, 78, and 46 days, respectively). The median OS was not reached in TKM only, even though the sample size was small (N = 12). Even after adjusting for clinical factors associated to liver, renal, and hematologic manifestation, ICT still remained significant.Conclusions: We demonstrated that ICT might be beneficial for advanced cancer regardless of the performance status, liver and renal function, since it positively affected the OS.
An Analysis of Aconiti Ciliare Radix Patents
Authors: Kim Che-Yeon , Kim Ki Su , Lee Sang-Hyun , Hwang Man-Suk
Published: September 2022

Objectives: The purpose of this study is to investigate and analyze Korean domestic patents on aconiti ciliare radixand to identify the trend of aconitum tuber technology.Methods: To analyze the patent, a combinations of words such as “aconitum” or “korean aconite root” were usedin search engine Kipris(www.kirpis.or.kr). The patents of aconiti ciliare radix were analyzed in three ways: year trendanalysis, internatonal patent classification (IPC) code analysis related to content classification, and patent registrationstatus analysis.Results: Among the patents found in the search results, 17 patents with significant contents were analyzed. Resultsshowed that, first, patents were steadily registered until 2018, but recently there has been no new patent registration.Second, there were many patents related to efficacy verification and decoction method, and the number of IPC codesrelated to them was also high. Third, there are five patents maintaining the registration status, and they are patentsrelated to the aconiti ciliare radix extraction method, toxicity removal, and combination method.Conclusions: In this study, the domestic patents of aconiti ciliare radix were analyzed. The analysis results of thisstudy are expected to be exploited as basic data for the development of Korean medicine analgesics with fewer sideeffects by suppressing tuber toxicity and the creation of new medical technologies.
A study of Nutrient Qi(營氣) and Defense Qi(衛氣) from the modern perspective of Visceral body and Somatic body
Authors: Ju Da Hyun , Kim Byoung-Soo
Published: September 2022

Objectives: The aim of this study is to modernize Nutrient Qi(營氣) and Defense Qi(衛氣) from the point of view of Visceral Body and Somatic Body.Methods: Investigate the areas of body and function of Nutrient Qi(營氣) and Defense Qi(衛氣) recorded in the 『HuangdiNeijing(黃帝內經)』 and 『Dongeuibogam(東醫寶鑑)』. And investigate Visceral Body and Somatic Body that anatomical structure is divided according to function based on the book 『Life and Rhythm』.Results: Nutrient Qi(營氣) works to nourish the body such as viscera and bowels in the meridian. Defense Qi(衛氣) works to protect the body such as skin, limb joint, eye outside the meridian. The human body is divided into Visceral Body called a vegetable organ and Somatic Body called an animal organ. Visceral body is the organ that manages “nutrition-reproductive” and is divided into the intestine(腸管), blood vessels(血管), and the nephridium(腎管). Somatic Body is an organ that manages ‘sensory-motion’ and is divided into a three-layer structure: the outer layer covering the body surface, the nerve layer connecting the outer layer and the muscle layer, and the muscle layer controling contraction and movement.Conclusions: It is estimated that Nutrient Qi(營氣) is similar to Visceral Body, and Defense Qi(衛氣) is similar to Somatic Body.
Peer Role-Play in a College of Korean Medicine to Improve Senior Students’ Competencies in Patient Care and Communication: A Case Analysis and Proposal for a Model
Authors: Cho Eunbyul , Jung Hyun-Jong , Leem Jungtae
Published: September 2022

Objectives: Peer role-play (PRP) has been used in health care training simulations because standardized patient training requires considerable time and expense. This study described the implementation of clinical simulation using PRP and examined the effect.Methods: Final year students from a single college of Korean medicine engaged in PRP as part of clinical skills practice. Education tools from clinical practice guidelines were used to structure the PRP. Communication competency was assessed with the Korean Version of the Self-Efficacy Questionnaire (KSE-12). Whether this training helped to achieve graduate outcomes was evaluated on a five-point scale.Results: Fifty-nine students (53.2%) participated in the survey. Among 12 items on the KSE-12, the score for "How certain are you that you are able to successfully listen attentively to the patient?" was the highest. Further, PRP was found to be helpful for self-directed learning, establishment of one's professional identity, and the ability to communicate and manage patients. Three themes ("Benefits of role-play", "The importance of positive feedback", "Limitations and problems of role-play"), 15 categories, and 16 central meanings were derived by categorizing learners' subjective opinions about PRP.Conclusions: Study findings indicate that PRP may contribute to improving communication skills and establishing a professional identity for future Korean medicine doctors. We suggest using PRP in clinical education in colleges of Korean Medicine.
Analysis of Weight Loss and Adverse Events in Overweight, and Obese Patients on Korean Medicine Weight Management Program with Face-to-Face Treatment and Non-Face-to-Face Treatment: A Retrospective Chart Review
Authors: Kim Eunjoo , Lim Young-Woo , Ok Ji-Myung , Kim Seo-Young
Published: September 2022

Objectives: The purpose of this study is to analyze the weight loss and the adverse events of overweight and obese adults on weight loss program with face-to-face treatment (FTF) and non-face-to-face treatment (NFTF) in 6 Korean Medicine obesity clinics.Methods: From March 2nd to March 10th, 2021, we collected data with a retrospective way from overweight and obese adults (body mass index, BMI≥23 kg/m2) who registered for a 12-week Gamitaeeumjowi-tang prescription program. After matching initial information of the FTF group and the NFTF group using propensity matching score, weight loss and BMI change were analyzed, and adverse events were evaluated in terms of causality, severity and system-organ classes.Results: Weight and BMI change from baseline to 12 weeks was -7.98±3.09kg (10.41±3.57%), -3.03±1.14kg/m2 and -7.30±3.11kg (9.59±3.45%), -2.76±1.15kg/m2 for FTF group and NFTF group, respectively. Body weight and BMI significantly decreased before and after treatment in both groups, and there was no significant difference in weight loss and BMI change between the two groups. No serious adverse events were reported.Conclusions: This study showed the potential that NFTF weight management treatment could be a good alternative way to FTF weight management treatment without serious adverse events.
The effect of isoflavonoid contents in SH003 and its subfractions on breast cancer
Authors: Choi Yu-Jeong , Choi Won-Geun , Lee Kangwook , Jeong Miso , Park Sang Cheol , Jang Young Pyo , Ko Seong-Gyu
Published: September 2022

Objectives: We investigated the isoflavone contained in SH003 and its fractions, and the effect of these components on the inhibition of breast cancer.Methods: The isoflavones in solvent fractions of SH003 extract were identified by UPLC-MS and its contents were quantified using HPLC analysis. The estrogenic activity of SH003 or fractions was assessed by ERE luciferase assay in estrogen receptor (ER)-positive MCF-7 cells. To test the breast cancer inhibitory effect, the cell viability was measured using an MTT assay.Results: In this study, we demonstrated that SH003 and fractions contain 4 isoflavones which are calycosin-7-β-D-glucoside, formononetin-7-β-D-glucoside, calycosin, and formononetin. Despite containing isoflavones, estrogen-dependent transcription activity was not altered by both SH003 and fractions. On the other hand, SH003 and fractions inhibited the cell viability of breast cancer. In addition, its isoflavone components also showed reduced cell viability in various breast cancer cells.Conclusions: Overall, the phytoestrogen included in SH003 and fractions did not influence the estrogenic activity, emphasizing the safety of SH003 and fractions in breast cancer treatment.
Should Korean Medicine doctors use modern diagnostic medical devices? Survey result of public perspectives
Authors: Kim Juchul , Hwang Byoungcheun , Hwang Manki , Lee Seungmin Kathy , Yi EunHee , Leem Jungtae
Published: September 2022

Objectives: This study investigated public opinion on the use of modern diagnostic medical devices by Korean Medicine doctors.Methods: A questionnaire looking into perceptions on the use of modern medical devices was developed. It was distributed by a third party and data was collected. Results were analyzed through frequency analysis, chi-square analysis (χ²-test), frequency and cross analysis using R program. The measurement variable in the study was the respondent’s perspectives and expectations on the use of modern diagnostic medical devices by Korean Medicine doctors. The maximum significance level was 0.05.Results: There were a total of 3,000 responses and 80.8% of the respondents replied that there is a need for government-level discussion on endowing rights to Korean Medicine doctors as supervisors for safety management of radiation generating devices. Also, 83.3% of the respondents agreed the use of ultrasound imaging equipment in Korean Medicine clinics should be legalized.Conclusions: According to this study, respondents strongly support the use of modern diagnostic medical devices by Korean Medicine doctors. This is the first study to investigate public opinion in this area and it provides a significant insight into the public needs and desires for a wider scope of practice for Korean Medicine in the healthcare system.
Anti-inflammatory Effect of Cornus Officinalis fruit extract and Cornus Officinalis Fruit Cheonghyeol Plus in Human Umbilical Vein Endothelial Cell
Authors: Kim Jeong-hui , Yoo Ho-ryong , Seol In-chan , Kim Yoon-sik
Published: September 2022

Objectives: The purpose of this study was to investigate the anti-inflammatory effect of Cornus Officinalis fruit extract(CE) and Cornus Officinalis Fruit Cheonghyeol Plus(CCP) in Human Umbilical Vein Endothelial Cell.Methods: We measured cell viability of CE, CCP and treated HUVEC with TNF-α. We measured the mRNA expression levels of KLF2, eNOS, MCP-1, ICAM-1, VCAM-1, the protein expression levels of KLF2, eNOS, MCP-1, ICAM-1, VCAM-1, and the protein phosphorylation level of ERK, JNK, p38 and the biomarker expression levels of MCP-1, ICAM-1, VCAM-1.Results: 1.CE incresed the mRNA, protein expression levels of KLF2, eNOS at concentrations of 100㎍/㎖ compared to the control group. CE decresed the mRNA, protein and biomarker expression levels of MCP-1,ICAM-1,VCAM-1 at concentrations of 100㎍/㎖ compared to the control group. CE decresed the protein phosphorylation level of p38 at concentrations of 100㎍/㎖ compared to the control group. 2. CCP incresed the mRNA, protein expression levels of KLF2, eNOS at concentrations of 100㎍/㎖ or more compared to the control group. CCP decresed the mRNA, protein and biomarker expression levels of MCP-1, ICAM-1, VCAM-1 at concentrations of 100㎍/㎖ or more compared to the control group. CCP decresed the protein phosphorylation level of ERK at concentrations of 100㎍/㎖ or more, p38 at concentrations of 200㎍/㎖ or more, and JNK at concentrations of 400㎍/㎖ compared to the control group.Conclusions: These results present that CE and CCP has anti-inflammatory effect in HUVEC. So, it could help treat or prevent inflammation in vein caused by dyslipidemia and contribute prevention of cardiovascular and cerebrovascular cerebrovascular diseases.
A Survey on Korean Medicine Doctors’ Recognition and Treatment for Developing Korean Medicine Clinical Practice Guideline of Female Infertility
Authors: Jung Hyo-Jeong , Kim Dong-Il , Choi Su-Ji , Hwang Su-In , Yoon Young-Jin , Park Jang-Kyung
Published: September 2022

Objectives: This study was conducted to develop a Korean Medicine(KM) Clinical Practice Guidelines(CPG) of female infertility. We conducted this questionnaire survey to reflect the experiences of Korean Medicine doctors(KMD) and clinical field in Korea.Method: We sent a questionnaire survey to KMD belonging to the Association of Korean Medicine by e-mail. We received 665 responds, and analyzed the answers.Results: 51.2% of respondents knew the previously developed CPG of female infertility, and 18.3% actually used. 83.3% agreed about the necessity of CPG of female infertility, and 80.3% had practical use plan. 90.2% of respondents treated less than 5 infertility woman for a month. 22.7% of respondents treated 50% of patients with collaborative treatment of KM and Western medical treatments. The main age group of patients was ‘35~40 years’(54.7%), and the most common cause was unexplained infertility(61.7%). The most common pattern identification of female infertility patients was Kidney deficiency(55.4%). KMD used 'a combination of decoction of herbal medicine, acupuncture and moxibustion treatment' the most(43%), and 'a decoction of herbal medicine treatment alone' was next(35%). 84.2% conducted lifestyle modification education about diet, stress, exercise etc.Conclusion: We figured out Korean Medicine doctors' recognition about CPG of female infertility, preference of treatments, and also characteristics of patients visiting Korean Medical clinics to make a practical CPG reflecting clinical situation.
Clinical Effectiveness of Ikgibohyeol-tang(Yìqìbǔxuè-tāng) and Deer Antler on Fatigue Symptoms and HRV Results in Outpatients at Korean Medical Hospital: A Retrospective Chart Review Study
Authors: Ha Won Jung , Moon Sang-Kwan , Lee Han-Gyul , Cho Seung-Yeon , Park Seong-Uk , Jung Woo-sang , Park Jung-Mi , Ko Chang-Nam , Cho Ki-Ho , Kwon Seungwon
Published: September 2022

Objectives: This study was designed to investigate the clinical effectiveness of Ikgibohyeol-tang(Yìqìbǔxuè-tāng) granules and Deer antler granules on fatigue symptoms.Methods: This is a 39-patient case series from a retrospective chart review of outpatients who were treated with Ikgibohyeol-tang granules and Deer antler granules at a Kyung Hee University Korean Medicine Hospital (Seoul) between 1st, January 2015 to 1st, August 2021. We reviewed the patients who complained of fatigue and analyzed changes in the degree of discomfort with fatigue and accompanying symptoms and HRV (Heart Rate Variability) score before and after treatment.Results: After taking Ikgibohyeol-tang granules and Deer antler granules, the degree of discomfort with fatigue and accompanying symptoms decreased significantly compared to before taking them. After treatment, Autonomic nervous system activity, Stress resistance, Heart Stability increased, and Stress index, Degree of fatigue decreased significantly.Conclusions: This study showed subjective symptoms and objective indicator (HRV score) were improved by taking Ikgibohyeol-tang granules and Deer antler granules.