bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of the neuroprotector isatin on complex formation of beta-amyloid peptide fragments with some intracellular proteins
Authors: Buneeva O.A. , Gnedenko O.V. , Medvedeva M.V. , Ivanov A.S. , Medvedev A.E.
Published: October 2018

Amyloid-β peptide (1-42) (Aβ1-42) is a key player in the development and progression of Alzheimer’s disease (AD) and related pathologies, determined by formation of protein aggregates in the central nervous system. Aβ1-42 binding to crucial intracellular targets (and their subsequent inactivation) obviously represents one of the earliest events preceding extracellular pathogenic oligomerization/aggregation of Aβ1-42. It is reasonable to expect that dissociation of the Aβ1-42 complexes with intracellular proteins by means of inhibitors followed by subsequent degradation of Aβ1-42 would not only protect critically important proteins but also prevent intracellular accumulation of Aβ1-42. The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Aβ-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Aβ1-42 and its fragments (Aβ1-28, Aβ12-28, Aβ25-35). Aβ1-42 and its fragments (Aβ1-28, Aβ12-28, Aβ25-35) immobilized on the Biacore optical biosensor chip interacted with GAPDH and pyruvate kinase. The lowest and basically equal Kd values were determined for GAPDH and pyruvate kinase complexes with immobilized Aβ1-42 and Aβ25-35. The presence of 100 mM isatin caused a significant (more than fivefold) increase in the Kd values for GAPDH complexes with all Aβ peptides except Aβ1-28. In contrast to GAPDH isatin increased dissociation of pyruvate kinase complexes only with Aβ1-42 (causing a 30-fold increase in Kd) and to a lesser extent with Aβ12-28 and Aβ25-35 (a 10-fold increase in Kd). It should be noted that in the presence of isatin the Kd values for GAPDH and pyruvate kinase complexes with all Aβ studied were in a narrower concentration range (10-7 M – 10-6 M) than in the absence of this neuroprotector (10-8 M – 10-6 M). Data obtained suggest existence of principal possibility of (pharmacological) protection of crucial intracellular targets against both Aβ1-42, and its aggressive truncated peptides (Aβ25-35).
The influence of humus acids of peloids and its components on free radical processes
Authors: Avvakumova N.P. , Kamilov F.H. , Zhdanova A.V. , Men’shikova I.A. , Zhernov Yu.V. , Krivopalova M.A. , Glubokova M.N. , Katunina E.E.
Published: October 2018

The effect of individual components of humic substances of peloid on free radical oxidation processes has been investigated under conditions of oxidative stress induced in albino rats. Biological activity of peloids was determined using such parameters as the general antioxidant activity, activity superoxide dismutases, catalases and glutathione peroxidases on the third and tenth day of the experiment. Results indicate that the state of oxidative stress can be corrected on the third day of the experiment. Humic acids restore not only normal physiological redox systems, but also increase the activity of antioxidant enzymes on the 10th day.
Factors governing development of nonalcoholic fatty liver disease and insulin resistance in obesity
Authors: Vulf M.A. , Kirienkova E.V. , Skuratovskaia D.A. , Levada E.V. , Volkova L.V. , Zatolokin P.A. , Gazatova N.D. , Litvinova L.S.
Published: October 2018

The factors promoting development of non-alcoholic fatty liver disease in patients with obesity and different state of carbohydrate metabolism have been studied. 43 patients were examined; these included 26 patients with abdominal obesity (BMI=52.9±7.9 kg/m2). The control group consisted of 17 conditionally healthy donors without obesity (BMI=18.9-24.9 kg/m2), seven of them formed a comparison group that was included to compare the results of study on the levels of tissue-specific expression of HSP70 mRNA. The study of mRNA expression was performed by real-time PCR. The concentration of IL-6 and TNF-a was measured in blood serum by the ELISA method. In patients with obesity with diabetes mellitus type 2 (DM2), a significant increase in the serum level of proinflammatory cytokines was found in comparison with the group of patients without DM2 and control. The results of histological examination of liver biopsy specimens in obese patients revealed the most pronounced changes in the group of DM2 patients. Regardless of the stage of nonalcoholic fatty liver disease in obese DM2 patients, an increase in the area of fatty inclusions (relative to the group without type 2 diabetes) was recorded. The study of the HSP70 gene expression in peripheral blood mononuclear cells allowed its significant increase relative to the comparison group. The relationship between the level of expression of the HSP70 gene in metabolically active tissues (visceral, subcutaneous adipose tissue and liver) established in all obese patients with the serum content of proinflammatory cytokines (IL-6 and TNF-a) may indicate suppression of HSP70 expression in these tissues, background of systemic and local inflammation in obesity.
Chronic alcoholism influences the mRNA level of the orexin receptor type 1 (OX1R) in emotiogenic structures of the rat brain
Authors: Airapetov M.I. , Sekste E.A. , Eresko S.O. , Bychkov E.R. , Lebedev A.A. , Shabanov P.D.
Published: October 2018

Orexin and its receptors were shown to be involved into mechanisms of pathological craving to alcohol. This paper demonstrates that the orexin receptor type 1 (OX1R) mRNA level significantly decreased in the prefrontal cortex of rats chronically (during 6 months) consuming ethanol compared with intact control. The same results were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level did not change on the day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. These findings point out involvement of the prefrontal cortex and hippocampus first of all in mechanisms mediating chronic alcohol intoxication. The ventral tegmental area is described as a typical dopaminergic structure providing the executive mechanism of emotion reactions connected with alcohol abuse in particular. It is possibe, that the modulating action of orexins on dopaminergic neurons in this structure does not provide a significant effect on control of emotion reactions in alcoholism.
Drug utilization study of antihypertensive drugs in a tertiary care hospital
Authors: Radhika A. R.
Published: October 2018

Background: Hypertension is a major common disease and effects a million of people worldwide. And is risk factor for other diseases like cardiovascular diseases, stroke etc. The aim of our study was undertaken to study the utilization pattern of anti hypertensive drugs at a tertiary care hospital. The guidelines for the treatment of hypertension are put forward by the Joint National Committee (JNC) on detection, evaluation and treatment of blood pressure. The Indian guidelines endorsed by the cardiology society of India, the hypertension society of India, and Indian college of physicians closely follow the JNC guidelines.Methods: A prospective cross-sectional observational study was conducted on 100 patients in outpatient Department of General medicine of Government General Hospital, Mahabubnagar district, Telangana. The data collected was analysed from the prescription pattern of anti hypertensive drugs. The data collected were statistically analysed and presented as counts and percentages.Results: Out of 100 study subjects, males were 55% and females were 45% and maximum number of patients in age group are (51 to 60 years.). Among antihypertensive drugs commonly used in present study are Losartan (ARB’s)-64% and for two drug therapy are enalapril and amlodipine 22% and for three drug therapy are enalapril +atenolol+furosemide-14%. Average number of drugs prescribed is 6.15% per prescription. Percentages of medicines prescribed by generic drugs are85% and from the essential drug list are 95%.Conclusions: In this study usage of anti hypertensive drugs were prescribed rationally in tertiary care hospital. The study emphasizes that need for effective continuing medical education and also preventive measures in hypertensive individuals.
Trends of etiology and treatment in hepatocellular carcinoma over the years
Authors: Vatansever Sezgin , Pakoz Zehra B.
Published: October 2018

Background: HCC has been the fastest-growing cause of cancer-related deaths. The aim of this study was to investigate the change trends in the etiology, treatment and mortality of HCC over the last 12 years.Methods: The study included 523 patients who were admitted to our clinic with the diagnosis of primary malignancy of the liver between 2006-2018. Demographic data, HCC etiologies, alpha feto-protein (AFP) values and imaging characteristics were recorded. The patients were divided into two groups as diagnosed before 2013 and 2013 and later. Because the number of patients with alcohol and HBV was high, it was evaluated as a separate etiology group. HCC was accepted related to NASH in the patients with obesity and diabetes mellitus (DM) after exclusion of HBV, HCV, and autoimmune hepatitis. The patients without obesity and DM were accepted as cryptogenic HCC and added to other etiologies group.Results: When the patients were evaluated, there was a significant increase in the rate of patients who were in compensated cirrhosis stage and in UCSF criteria in and 2013 and later (p = 0.0001, p = 0.037, respectively). A significant increase was observed in the ratio of NASH-related HCC 2013 and later (p = 0.032). Transplantation, resection and RFA / PEI rates were 14.9% before 2013 and 22.2% 2013 and later (p = 0.047).Conclusions: The rates of NAFLD related HCC due to diabetes and obesity are increasing. Knowing the change of HCC causes over the years is necessary for the effective treatment for these reasons in the future.
Evaluation of anti-diabetic prescriptions at Tripura medical college and Dr. BRAM teaching hospital: a cross- sectional study
Authors: Das Lakshman , Debnath Shubhaleena , Bhattacharjee Prithul
Published: October 2018

Background: Diabetes mellitus (DM) is a chronic disease which requires lifelong treatment. The management of type 1 DM depends mainly on insulin, whereas the oral anti-diabetic drugs (OADs) are the first line treatment for type 2 DM. Rational use of the drugs in populations can be effectively studied by analysing the prescription pattern. As there are limited numbers of studies carried out on drug utilization in diabetic patients in North Eastern region of India, authors planned to carry out this study in a tertiary care set up of this region.Methods: A cross-sectional study was carried out in Medicine OPD of Tripura Medical College and Dr. BRAM Teaching Hospital for a period of two months with the objectives of prescription pattern evaluation and the cost of anti-diabetic agents. Drug use pattern of antidiabetics, WHO core prescribing indicators and percentage of cost variation were analysed.Results: A total of 120 prescriptions were analysed during the study period. Metformin was the most commonly prescribed drug. The average cost of therapy per prescription per week was Rs. 94.54. Only 19.43% of the antidiabetics were prescribed from the essential drug list.Conclusions: The cost of prescription can be reduced by choosing the generic drugs without changing its quality and also by choosing drugs from essential drug list.
Editorial
Authors: Quarmby Kevin , Jenstad Janelle
Published: October 2018

Editorial: 2017 Issue 1
Saying it Like "Indians": The Wooster Group's Cry Trojans!, Sa(l)vage Ethnography, and the Politics of "Playing Injun"
Authors: Hollis Gavin
Published: October 2018

For the production: Cry Trojans! (2015, The Wooster Group, USA).
Much Ado About Nothing at the Atlanta Shakespeare Tavern
Authors: Burris Nina
Published: October 2018

For the production: Much Ado About Nothing (2016, Atlanta Shakespeare Company, USA).
Lazarus Theatre's All-Female Henry V at The Union Theatre, London
Authors: Quarmby Kevin
Published: October 2018

For the production: Henry V (2015, Lazarus Theatre Company, England).
A Midsummer Night's Dream at the Stratford Festival
Authors: McKeown Roderick H. , Star Sarah
Published: October 2018

For the production: A Midsummer Night's Dream (2014, Stratford Festival of Canada, Canada).
Stratford's Breath of Kings Rallies Forces through Redemption
Authors: Volz Jim
Published: October 2018

For the production: Breath of Kings: Redemption (2016, Stratford Festival of Canada, Canada).
Murky Macbeth Elicits Standing Ovation at Canada's Stratford Festival
Authors: Volz Jim
Published: October 2018

For the production: Macbeth (2016, Stratford Festival of Canada, Canada). See
Canada's Shakespeare in Love Proves Touching and Wonderfully Waggish
Authors: Volz Jim
Published: October 2018

Shakespeare in Love (2016, Stratford Festival of Canada, Canada).
Henry V at the Oregon Shakespeare Festival
Authors: Minton Gretchen
Published: October 2018

A review of the 2018 Oregon Shakespeare Festival production of Henry V.
Nothing is Good without Respect
Authors: Arab Ronda
Published: October 2018

For the production: The Merchant of Venice (2017, Bard on the Beach, Canada).
"Like an old tale still": The Winter’s Tale and Bard on the Beach
Authors: Budra Paul
Published: October 2018

For the production: The Winter's Tale (2017, Bard on the Beach, Canada).
A Moveable Match: Troilus and Cressida
Authors: Cooke Virginia
Published: October 2018

For the production: Troilus and Cressida (2016, Canada).
Why They Are So Sad in Merchant of Venice
Authors: Kelly Erin
Published: October 2018

For the production: The Merchant of Venice (2017, Bard on the Beach, Canada).
Shakespeare, Lord of Love and Changes
Authors: Parmar Prabhjot , Walter Melissa
Published: October 2018

For the production: Piya Behrupiya "The Beloved Imposter" (2016, The Company Theatre, Canada).
OPS Fest The Taming of the Shrew
Authors: Tavares Elizabeth
Published: October 2018

For the production: The Taming of the Shrew (2017, Original Practice Shakespeare Festival at the Mission Theatre).
An Existential Crisis? Freedom, Tolerance, Solidarity, Peace; Or, Why Europe is Valuable
Authors: Bengoetxea Joxerramon
Published: October 2018

This paper addresses Europe’s existential crisis. It does so by suggesting that, notwithstanding the relevance of the institutional design, the essence of the project of European integration is persons and peoples rather than states. It then discusses two speeches of important personalities speaking about Europe’s existential crisis. Next, it deals with the question of diversity since the motto of the failed constitutional treaty was precisely “united in diversity”. But this requires explaining the centrality of the individual in practical reason, and the importance of normative systems. The centrality of the individual, related to the value of freedom, is then placed in the context of plurality and diversity, directly addressing the theme of backlash forces in Europe through a map of such plurality in Europe; the socalled multiculturalism or ethno-religious pluralism. The paper concludes by suggesting a version of cosmopolitanism, hermeneutic pluralism, as the normative position to address the balance between individual freedom and solidarity or between “persons” and “peoples”.Received: 15 January 2018 Accepted: 9 May 2018 Published online: 31 October 2018
Prioridades y medios de la estrategia de comunicación de la Unión Europea: aciertos y desafíos
Authors: Hernández Ruiz Marta
Published: October 2018

Desde el rechazo al Tratado Constitucional en los referéndums de Francia y Países Bajos, la Comisión Europea y el Parlamento Europeo han liderado el esfuerzo por mejorar la comunicación entre la Unión Europea y sus ciudadanos. El propósito de este artículo es estudiar sus estrategias comunicativas a partir de tres ejes: los objetivos que las propias instituciones han designado como prioritarios en materia de comunicación, la estructura organizativa que la Comisión Europea y el Parlamento Europeo han elegido para lograr esos propósitos y el presupuesto que han destinado estas instituciones para ello. Este método de análisis relacional permite estudiar la estrategia de comunicación de la Unión Europea como una estructura. Se parte de la premisa de que los tres ejes deben ser coherentes entre sí para lograr una estrategia eficiente. Y, a partir de las conclusiones alcanzadas, se realizan propuestas de mejora pragmáticas.Recibido: 5 abril 2018 Aceptado: 7 junio 2018 Publicación en línea: 31 octubre 2018
Crónica Comunitaria: actualidad institucional y económica de España en el marco de la Unión Europea (junio de 2018)
Authors: Iñarritu Beatriz
Published: October 2018

Sumario: I. Introducción.—II. El Estado de la Integración. 1. Propuesta de profundización en la Unión Económica y Monetaria. 2. Brexit: Acuerdo sobre las condiciones del período transitorio del Brexit. 3. Luis de Guindos, vicepresidente del BCE.—III. Cuestiones generales de la actualidad económica. 1. BCE: Anuncio de la finalización del Programa de compras masivas de deuda (QE) en diciembre de 2018. 2. El Eurogrupo acuerda la finalización del rescate a Grecia y la reestructuración de la Deuda griega. 3. Guerra comercial con Estados Unidos ante la imposición de aranceles al acero y aluminio europeos. 4. MUR: polémica en relación a la resolución del Banco Popular. 5. Trabajadores desplazados: acuerdo sobre una nueva normativa. 6. Nuevas sentencias del Tribunal Europeo sobre las indemnizaciones a los trabajadores temporales españoles. 7. Semestre Europeo 2018: Informes en profundidad sobre Desequilibrios Macroeconómicos y Recomendaciones Específicas por país. 8. Competencia-Pacto fiscal Luxemburgo - Engie.Publicación en línea: 31 octubre 2018
La crisis europea de la política: pluralismo etno-religioso y el auge del populismo y la extrema derecha en Europa
Authors: Astier Cristina , Errasti Ander
Published: October 2018

No genera mucha polémica sostener que la crisis económica del 2008 puede entenderse como un fracaso de los estados de bienestar europeos. Tanto el incremento de las desigualdades económicas parcialmente motivadas por esta crisis global, como el aumento de los flujos migratorios, han contribuido a crear un caldo de cultivo para el auge de los discursos de odio racial, religioso e ideológico en occidente. Sin embargo, haciendo la comparación con periodos históricos previos en los que surgieron tensiones equiparables, la ciudadanía de hoy en día puede canalizar sus intereses, necesidades, emociones, pensamientos e ideales políticos a través de las instituciones que conforman la estructura básica del estado. Así, la ciudadanía puede empoderarse canalizando sus reivindicaciones a través de mecanismos democráticos y distintas formas de participación política. Como ejemplo, una articulación relevante han sido las nuevas expresiones de populismo radical, nativismo e ideologías de extrema derecha que han surgido en varios niveles de la esfera pública y en distintas sociedades europeas. Esta combinación ha hecho que lo que era en un principio una crisis económica y de refugiados se haya convertido en una crisis que es sobre todo política.Publicación en línea: 31 octubre 2018
Jurisdição criminal brasileira e as Cortes Internacionais de Direitos Humanos: diálogos necessários
Authors: Luz Denise , Giacomolli Nereu José
Published: October 2018

O diálogo necessário entre as Cortes, no plano vertical e também horizontal permite o estabelecimento de standards protetivos das garantias processuais criminais, inseridas no âmbito do justo processo penal. A transposição da normatividade e da jurisdicionalidade domésticas, na perspectiva da superação do monólogo doméstico, são exigências de uma tutela jurisdicional efetiva. A efetividade das garantias processuais penais exige aderência legal, constitucional e, sobretudo, convencional pro homine.
Cidadania: uma leitura a partir do sistema escravista e suas implicações na (de)formação das práticas republicanas no Brasil
Authors: Silva Juvêncio Borges , Silveira Ricardo dos Reis
Published: October 2018

O artigo objetiva mostrar como o sistema escravista plasmou as várias relações no Brasil, e como a cidadania, que deveria se manifestar de forma republicana, universal, com o devido respeito às leis instituídas e à pessoa humana, foi enviesada por relações de natureza pessoal, por processos de dominação e negação, seja em relação ao escravo, seja em relação aos homens livres e miseráveis que constituíam a maioria absoluta da população brasileira, criando a cultura do favor que até hoje se encontra arraigada nas práticas sociais, políticas e jurídicas, em total descompasso com os princípios e práticas republicanos. O método adotado foi o analítico-dedutivo, valendo-se de material histórico, sociológico e jurídico, a partir de livros e artigos científicos, que foram analisados na elaboração da pesquisa.
Municipality and Open Government. Case study of Guazapares, Mexico
Authors: Gutiérrez-Diez María del Carmen , Piñón Howlet Laura Cristina , Sapién Aguilar Alma Lilia
Published: October 2018

How real is the promise of an open and close government to the people? Have technologies allowed this promise to become a reality? The objective of this research is to describe the situation concerning the Open Government model in the municipality of Guazapares, located in one of the most remote areas in the Sierra Tarahumara, in the northern state of Chihuahua, Mexico. The study was done through a case study methodology that made a description of the situation the municipal government regarding open government; an in-depth documentary investigation, and in-depth interviews with those responsible for transparency of the municipality in question. The results found strong barriers to the digital inclusion of municipal authorities and for the teachers who work in this municipality. These findings allowed to conclude that because of this gap, the promise of an open government is still far away from being real in this municipality.
19. YÜZYILDA YAPILMIŞ BİR KIYAFETNĀME TERCÜMESİ: DIMAŞKḬ’NİN KİTĀBÜ’L- ĀDĀB VE’S- SİYĀSET FḬ ʿİLMİ’N-NAẒARİ VE’L- FİRĀSET’İ
Authors: BUÇUKCU Zeynep
Published: October 2018

Bu çalışmanın konusunu Ebḭ ʿAbdillah bin Muḥammed bin Ṭālibü’l- Enṣārḭ
ed-Dımaşkḭ’nin hicri 750 (miladi: 1349/1350) yılında yazmış olduğu Kitābü’l-
Ādāb ve’s- Siyāset fḭ ʿİlmi’n-Naẓari ve’l- Firāset adlı kıyafetnāmesinin Salim
Sıdkı Silistrevḭ tarafından 1874 yılında yapılan Türkçe çevirisi oluşturmaktadır.
Eser İSAM Kütüphanesi’nde 178789 yer
numarasıyla kayıtlıdır. Yazar eserine Tanrı’ya hamd ve peygambere duanın
ardından kıyafet ilminin dayanaklarını oluşturan ayet ve hadislerden bahsederek
başlamakta, alanın başlıca kişileri hakkında bilgi vermekte ve onlardan
yapacağı alıntıları kısaltmalarla göstereceğini belirttikten sonra bölümlemeden
bahsetmektedir. Eseri oluşturan yirmi altı bap şu şekilde sıralanmıştır: baş,
saç, yüz, alın, kaş, göz, kulak, burun, ağız dudak ve dişler, yanak ve sakal,
boyun, omuz, pazı dirsek ve bilek, el parmak ve tırnak, göğüs ve karın, sırt,
but ve kalça, diz baldır ve ayak parmakları, boy ve yürüyüş, ses ve gülüş, avuç
içi, benler, parmaklar, ömür uzunluğu, yedi ırk, hayvanlar kuşlar vahşi
canlılar ve böcekler. Bu çalışmada eser hakkında bilgi verilmiş, Türk
edebiyatında kıyafetnāme türü içindeki yeri belirlenmeye çalışılmıştır.
KUR’AN’IN FAZİLETLERİNDEN SÖZ EDEN METHİYE TÜRÜNDE BİR MANZUME: MEDHU KUR’ÂNİ ‘AZÎMİ’Ş-ŞÂN VE BİHİ NESTA‘ÎN
Authors: SAĞLAM Ayşe
Published: October 2018

Kur’an-ı Kerim, klasik Türk
edebiyatının temel kaynaklarından biridir. Türkçe satır arası Kur’an
çevirileriyle başlayan bu ilgi; ayet, sure ve Kur’an tefsirleriyle devam eder.
Kur’an-ı Kerim’de zengin bir çağrışım imkânı yakalayan bu edebiyatta, Kur’an ayetleri
telmih ve iktibas yoluyla kullanılır. Kur’an’da geçen birçok kıssaya telmih
yoluyla yer verildiği gibi bu kıssalar birçok edebî türe de kaynaklık eder.
Ayrıca Kur’an’ın kendisi bir edebî teşbih unsuru olarak birçok benzetmeye konu
olur.  Sayıları sınırlı da olsa
Kur’an’daki sure ve ayetlerin tercüme ve tefsirlerini ihtiva eden ya da Kur’an
surelerinin isminin nazmedildiği manzumeler de kaleme alınmıştır. Sure
isimlerinin nazmedildiği manzumelerde sure adlarının ezberlenmesini
kolaylaştırmak ve surelerin sahip oldukları bir takım hususiyetleri kavratmak
hedeflenirken tercüme ve tefsirlerde sure ve ayetlerin faziletlerinin
anlaşılması hedeflenmiştir. Bu tarz eserlerin büyük çoğunluğu, Kur’an’ın
bütününden ziyade Kur’an’daki bazı sure ve ayetlerin faziletlerine
hasredilmiştir. Diyarbakır Ziya Gökalp
Yazma Eser Kütüphanesi 516 numarada Medhu Kur’âni ‘Azîmi’ş-şân ve bihi nesta‘în
başlığıyla kayıtlı olan şiir, bütün olarak Kur’an’ın faziletlerinden söz eden
methiye türünde bir manzumedir. 52 dörtlükten müteşekkil bu manzume, sadece
belirli sure ya da ayetlerin değil, bir bütün olarak Kur’an’ı Kerim’in
faziletlerinden söz etmesi yönüyle ehemmiyetlidir. Kur’an-ı Kerim’i tercüme ya
da tefsir etmeye dönük olmayan bu manzumede, doğrudan Kur’an’ın faziletlerinden,
okunma adabından, şefaatinden, Kur’an okumanın ve öğretmenin ecrinden,
hükümlerine riayet etmenin ehemmiyetinden söz edilir.

Bu çalışmada Medhu Kur’âni
‘Azîmi’ş-şân ve bihi nesta‘în isimli manzume tanıtılacak ve şiirin çeviri
yazılı metni verilecektir.
MAZMUN BEYANINDADIR: KLÂSİK TÜRK ŞİİRİNDE MAZMUN ARAYIŞINA KATKILAR
Authors: ŞENÖDEYİCİ Özer
Published: October 2018

Mazmun sözcüğü, günümüzde edebî bir terim olarak kullanılmaktadır. Ancak bu terim, araştırmacıların üzerinde uzlaşı sağladıkları bir kavram değildir. Eski şairler sözcüğe özel bir anlam yüklememişler, onu genellikle “mana, mefhum” karşılığında kullanmışlardır. Bununla birlikte sözcük, beyitte açıkça görünmeyen, remizli anlam şeklinde de izah edilmiştir. Akademik çalışmaların bazılarında ise, klâsik Türk şiirinin kalıplaşmış istiareleri, yani klişeleri, mazmun olarak nitelenmiştir. Günümüzde mazmun, beyitteki sözcüklerin oluşturduğu çağrışımların işaret ettiği kavram ya da nesne anlamında, bir edebî terim olarak kullanılmaktadır.Mazmun konusunda yapılan çalışmalarda verilen örnek sayısının kısıtlı olması, ona eski şairlerin rağbet göstermedikleri izlenimini uyandırmaktadır. Hâlbuki mazmun örnekleri, klâsik şiir geleneğine vâkıf okur ve araştırmacıların okumaları ile zenginleşebilir. Bu çalışmada mazmun literatürüne, Emrî Divanı’ndaki tanıklarla katkı sağlanacaktır. Örnek beyitlerdeki mazmunlar izah edilecek, bu esnada karşılaştırmalı bir yöntem izlenecektir. Ayrıca mazmunun terimleşme süreci kronolojik olarak verilecek, konu hakkındaki tartışmalara değinilecektir. Yapılacak yeni mazmun çalışmalarının yöntemine dair tespitler sayesinde, araştırmacıların bu konuya temayül etmeleri kolaylaştırılması; mazmun kavramının daha somut bir düzleme yerleştirilmesi amaçlanmaktadır.
Overview of Drug Allergy: From Immunogenetic Basis to Practice
Authors: Dias de Castro Eunice , Carolino Fabrícia , Ribeiro Laura , Cernadas Josefina R.
Published: October 2018

Drug therapy is often a balance between the beneficial and harmful effects of drugs. Drug allergic reactions are adverse reactions mediated by immunological mechanisms and usually not related to the pharmacological actions of the drug. They can be classified based either on the clinical presentation or the underlying immunological mechanism. Although uncommon, drug allergic reactions are unpredictable and can be very severe, even life threatening. The aim of this review was to provide clinicians from different medical specialties with a working tool to improve management of their patients with suspected drug allergy. It was conducted as a nonsystematic review, and attempts to describe the complexity of drug allergy. The information included ranges from pathophysiology to the heterogeneous clinical presentation, with a special focus on the drugs most frequently involved, as well as a classification of reactions and risk factors. Despite all advances in this challenging and complex field of allergy and clinical immunology, drug allergy is not yet fully established and understood. An exceptional contribution was brought by pharmacogenomics, even though a specific pharmacogenetic association has only been defined for a very limited number of drugs. Further studies are needed to obtain clearer answers when managing each individual case of drug allergy.
Repensar a Ciatalgia Perante Variação Anatómica Bilateral do Nervo Isquiático, com Origem Baixa e Divisão Alta: Importância Histórica, Anatómica e Clínica
Authors: Ribeiro Fernando Silva , Bettencourt-Pires Maria Alexandre , Silva Junior Edivaldo Xavier da , Casal Diogo , Casanova-Martinez Daniel , Pais Diogo , Goyri-O'Neill João Erse
Published: October 2018

Introdução: O objectivo do presente estudo é o relato de um caso de variação anatómica do nervo isquiático, por origem baixa e divisão alta bilateral.Material e Métodos: Foi dissecado um cadáver feminino de 66 anos, conservado pelas técnicas originais desenvolvidas no nosso departamento.Resultados: No trabalho regular de dissecção cadavérica da disciplina de Anatomia Regional II detectou-se nervo isquiático, em ambos os membros, com pequeno trajecto, de aproximadamente, 8 - 10 cm, dividido em nervos fibular comum e tibial, ao nível da margem inferior do músculo glúteo máximo.Discussão: Casos semelhantes aos do presente estudo, foram descritos por alguns autores desde Leonardo da Vinci, Da Cortona, ou Eustachius, demonstrando a importância desse conhecimento, tanto em termos clínicos, como cirúrgicos ou anestesiológicos. Diversas ilações são possíveis, por revisão do presente caso, infrequente.Conclusão: Para além de proporcionar conhecimento prévio da anatomia loco-regional, o estudo das variações do nervo isquiático orienta o melhor seguimento de patologias, bem como acessos cirúrgicos e/ou anestésicos. Por mais meticulosos que sejam os nossos estudos anatómicos, jamais poderemos considerar terminada ou definitiva a investigação em anatomia humana.
Letter to the Editor about the Article: “Still Regarding Anxiety, Depression and Academic Performance: A Study Amongst Portuguese Medical Students Versus Non-Medical Students”, by João Moreira de Sousa, Cátia A. Moreira, Diogo Telles-Correia. Acta Med Port. 2018;31:454-62.
Authors: Gama Marques João
Published: October 2018

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Symptomatic Solitary Gastric Diverticulum: A Rare Endoscopic Finding
Authors: Gravito-Soares Marta , Gravito-Soares Elisa , Tomé Luís
Published: October 2018

N/A.
Analysis of Prophylactic Antibiotics Usage in Caesarean Section Delivery
Authors: Muzayyanah Binti , Yulistiani Yulistiani , Hasmono Didik , Wisudani Nuraida
Published: October 2018

Caesarean section is the delivery through a surgical incision in the abdomen and uterus with various risks, such as Surgical Site Infection (SSI) which either occurs rapidly (24-48 hours postoperatively) or delayed. To reduce the risk of various post-cesarean section infections, prophylactic antibiotics are given. The administration of prophylactic antibiotics with recommended regimens, such as in developed countries as in the United States and Europe, with first generation of cephalosporins has not been applied in Dr. Iskak Hospital, Tulungagung. This hospital still used other types of antibiotics, such as cefotaxime or ceftriaxone. In addition, for several reasons, prophylactic antibiotics were continued with other antibiotics to reduce the risk of delayed infection. This study was designed to analyze the effectiveness of prophylactic antibiotics as recommended in cesarean section. This was a prospective observational study with consecutive sampling type, examined 41 mothers with cesarean section at the Department of Obstretics and Gynecology, Dr. Iskak Hospital, Tulungagung, Indonesia. This study was conducted from May to July, 2017. The results of the study showed that the effectiveness of prophylactic antibiotic use was 98% based on the clinical parameters and maternal laboratory outcome, which showed that SIRS was in normal category. Whereas, there was one mother (2%) who had SSI on day 10 postoperatively.
Analysis of Minichromosome Maintenance-2 (MCM-2) and Cyclin D1 Expression in Meningioma
Authors: Kurniawati Yuliana , Fauziah Dyah
Published: October 2018

World Health Organization histopathological grading of meningioma is associated with recurrence and clinical outcome. Grade II meningioma can be difficult to distinguish with grade I especially in case in which mitosis is not easily identified. MCM-2 and Cyclin D1 play crucial role in cell cycle and have been reported overexpressed in many malignant tumors. The aim of this observational analytic study was to analyze the differences and correlation between MCM-2 and Cyclin D1 in various meningioma grading. Immunohistochemystry with MCM-2 and Cyclin D1 was performed on 25 paraffin blocks of grade I, II and III meningiomas at the Laboratory of Anatomical Pathology, Dr. Soetomo Hospital. The immunoexpression are evaluated using Labelling Index, then analyzed statistically. The results showed significant difference in expression of MCM-2 within various meningioma grading (p=0.000) and significant difference in expression of Cyclin D1 within grade I and II also within grade I and III (p<0.050), but not in grade II and III (p>0.050). There was also positive correlation between MCM-2 and Cyclin D1 expression in various meningioma grading (rs=0.683, p=0.000). MCM-2 may play role in distinguishing various meningioma grading. Cyclin D1 can distinguish grade I and II also grade I and III, but not grade II and III. Overexpression MCM-2 was along with Cyclin D1 in various meningioma gradings.
q-Sumudu Transforms of Product of Generalized Basic  Hypergeometric Function and Application
Authors: Vyas V K , Al -Jarrah Ali A. , Purohit S.D.
Published: October 2018

The prim objective of commenced article is to determine q-sumudu transforms of a product of unified family of q-polynomials with basic (or q-) analogue of fox’s H-function and q-analog of I-functions. Specialized cases of the leading outcome are further evaluated as q-sumudu transform of general class of q-polynomials and q-sumudu transforms of the basic analogues of Fox’s H-function and I-functions.
Sodium Content of Processed Foods Available in the Mexican Market
Authors: Nieto Claudia , Tolentino-Mayo Lizbeth , Medina Catalina , Monterrubio-Flores Eric , Denova-Gutiérrez Edgar , Barquera Simón
Published: October 2018

Background: Sodium intake has been related to several adverse health outcomes; such as, hypertension, and cardiovascular diseases. Processed foods are major contributors to the population’s dietary sodium intake. The aim of the present study was to determine sodium levels in Mexican packaged foods; also to evaluate the proportion of foods that comply with sodium benchmark targets set by the UK Food Standards Agency (UK FSA) and those set by the Mexican Commission for the Protection of Health Risks (COFEPRIS). We also evaluated the proportion of foods that exceeded the Pan American Health Organization (PAHO) targets. Methods: This was a cross-sectional study that comprised data collected from the package of 2,248 processed foods from selected supermarkets of Mexico. Results: Many processed food categories contained excessive amount of sodium, being the processed meats (ham, bacon and sausages) those that have the highest concentrations. The proportion of foods classified as compliant in our sample was lower for international targets (FSA UK and PAHO) compared to the Mexican COFEPRIS criteria. Conclusions: These data provide a critical baseline assessment for monitoring sodium levels in Mexican processed foods.
A Trajectory-Based Method to Explore Reactions Mechanisms
Authors: Vázquez Saulo A. , Otero Xose L. , Martinez-Nunez Emilio
Published: October 2018

The method tsscds, recently developed in our group, discovers chemical reaction mechanisms with minimal human intervention. It employs accelerated molecular dynamics, spectral graph theory, statistical rate theory and stochastic simulations to uncover chemical reaction paths and to solve the kinetics at the experimental conditions. In the present review, its application to solve mechanistic/kinetics problems in different research areas will be presented. Examples will be given of reactions involved in photodissociation dynamics, mass spectrometry, combustion chemistry and organometallic catalysis. The source code can be downloaded from: http://forge.cesga.es/wiki/g/tsscds/HomePage
Overview of the Special Issue on the Development of Disaster Statistics
Authors: Sasaki Daisuke ,   International Research Institute of Disaster Science (IRIDeS), Tohoku University 468-1 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-0845, Japan, Ono Yuichi
Published: October 2018

At the Third UN World Conference on Disaster Risk Reduction (UNWCDRR) held in March 2015 in Sendai City, Japan, the Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR), containing seven global targets, was adopted by 187 UN member states. With its outcome-oriented but non-numerical targets, quantitative approaches for monitoring disaster damage and loss by national governments became mandatory. The Global Centre for Disaster Statistics (GCDS) in Tohoku University was established in April 2015. The GCDS is expected to contribute to the evidence-based policy making by national and/or local governments. In addition, the GCDS aims at creating a synergy effect among academia, the UN organizations, and private companies in order to provide unprecedented values to all stakeholders worldwide. Under such circumstances, the special issue aims at publishing the research results obtained so far from the relevant studies that have been mainly conducted at the GCDS. The guest editors of the special issue are pleased to publish 13 valuable academic articles closely related to the activities of the GCDS, contributing to the development of disaster statistics. Based on the features of the 13 articles contained in the special issue, there seems to be three major categories of research questions. The first one is to investigate disaster statistics and/or global disaster-related databases. The articles of the first category contribute to the clarification of the characteristics specific to disaster statistics. The second one is to utilize disaster statistics in order to develop the existing discipline-based research. The articles of the second category are quite beneficial for establishing a new possibility of applying disaster statistics for the research so far. The third one is to analyze a variety of issues by means of questionnaire surveys. The articles of the third category are issue-oriented and interdisciplinary. Last but not least, the guest editors hope that the special issue would certainly contribute to the literature of disaster statistics and accelerate their development.
The Purpose of the Statistical Database on the Great East Japan Earthquake
Authors: Maruya Hiroaki ,   International Research Institute of Disaster Science, Tohoku University 468-1 Aramaki-Aza-Aoba, Aoba, Sendai, Miyagi 980-8572, Japan, Torayashiki Tetsuya
Published: October 2018

The Statistical Database on the Great East Japan Earthquake (SDJE) has been developed as an information resource to assist in research and preparations for future disasters in Japan and other countries. The SDJE was initiated in January 2016 by the International Research Institute of Disaster Science (IRIDeS) of Tohoku University. As a university in the affected area of the Great East Japan Earthquake (GEJE), Tohoku University acknowledges with gratitude the participation in GEJE relief and recovery activities of organizations and people from elsewhere in the country and abroad, and in response has undertaken a number of initiatives to provide scientific information and the lessons from the GEJE. For example, IRIDeS hosts and acts as the secretariat of the Global Centre for Disaster Statistics and has now developed this new database. The SDJE provides comprehensive data on the GEJE in both English and Japanese, drawing widely on data originally provided by the national and local governments and private organizations, including considerable contents taken from the white papers of Japan’s Cabinet Office and other national ministries. The data coverage extends from the time of the GEJE to currently produced materials. In addition, a “Link Collection” of Japanese statistics related to disasters is provided to support statistical analysis of the social and economic effect of the GEJE, for example through correlation analysis, and to assist researchers to better understand the context of the disaster and the disaster statistics. It is hoped that many people worldwide will find the content of the database useful for disaster risk reduction activities.
Formation of Third Place by Evacuees from Nuclear Accident: Case Study of Wide Area Residents’ Association of Tomioka Town, Futaba County, Fukushima Prefecture
Authors: Matsumoto Michimasa ,   International Research Institute of Disaster Science (IRIDeS), Tohoku University 6-6-11-901-2 Aoba, Sendai, Miyagi 980-8579, Japan
Published: October 2018

This paper conducted a questionnaire survey of evacuees (residents of public-funded rented housing, home buyers, etc.) from Tomioka Town, who were displaced because of the nuclear accident in Fukushima in 2011. It aimed to understand the characteristics of the wide area residents’ associations as the “Third Place” by examining the relationship among the neighborhood association before and after the disaster, the neighborhood association at the evacuation district, and wide area residents’ associations. It was revealed that wide area residents’ associations could function as a relative Third Place, because the evacuees had a weak connection with the places they live in after evacuation, although they continue to have strong links with the neighborhood associations in the places where they lived before the disaster.
PENGARUH METODE LATIHAN DAN POWER TERHADAP KEMAMPUAN JUMP SERVICE BOLA VOLI
Authors: Hernawan Hernawan , Hartanto Ridzqi
Published: October 2018

Tujuan penelitian ini yaitu untuk mengetahui pengaruh dari variabel- variabel bebas yaitu metode latihan dan power otot tungkai terhadap variabel terikat yaitu peningkatan kemampuan jump service. Metode penelitian yang digunakan adalah desain penelitian treatment by level 2x2. Penelitian dilaksanakan di club Tunas Rafflesia Bengkulu. Data diperoleh dari tes kemampua jump service, sedangakan analisis data dilakukan dengan teknik statistik analisis varian. Hasil penelitian menyimpulkan hal-hal berikut: (1) terdapat perbedaan kemampuan jump service yang signifikan antara kelompok yang diberikan metode latihan barrier hops dan kelompok yang diberikan metode latihan box jump, (2) terdapat interaksi antara metode latihan dan power otot tungkai terhadap kemampuan jump service pada anggota club Tunas Raflesia Kota Bengkulu, (3) terdapat perbedaan yang signifikan hasil kemampuan jump service antara metode latihan barrier hops dengan metode latihan box jump pada siswa yang memiliki power otot tungkai tinggi, (4) terdapat perbedaan yang signifikan hasil kemampuan jump service antara metode latihan barrier hops dengan metode latihan box jump pada siswa yang memiliki power otot tungkai rendah.
Sebaran Dan Kekayaan Spesies Ikan Lais (Famili Siluridae) di Sungai Mahakam Kalimantan Timur
Authors: Jusmaldi Jusmaldi , Solihin Dedy Duryadi , Affandi Ridwan , Rahardjo M F , Gustiano Rudhy
Published: October 2018

Sebaran dan kekayaan spesies ikan lais (famili Siluridae) di Sungai Mahakam Kalimantan Timur belum banyak diketahui. Tujuan dari penelitian ini adalah untuk mengetahui sebaran spasio-temporal dan kekayaan spesies ikan lais di bagian hulu dan tengah Sungai Mahakam. Pengambilan contoh ikan dilakukan setiap bulan selama satu tahun dengan metode purposive sampling menggunakan berbagai jenis alat tangkap di empat lokasi penelitian yang meliputi bagian hulu Sungai Mahakam (Sungai Tering) dan bagian tengah Sungai Mahakam (Danau Semayang, Sungai Belayan dan Sungai Kedang). Data yang diperoleh dianalisis secara deskriptif. Hasil penelitian menunjukkan total ikan lais yang dikoleksi berjumlah enam spesies dan dua genus dari total 2567 individu yang tertangkap. Sebaran spesies berdasarkan lokasi penangkapan menunjukkan Ompok miostoma dan Kryptopterus apogon ditemukan pada semua lokasi, sedangkan  Kryptopterus bicirrhis ditemukan hanya di Sungai Tering. Kelimpahan individu Ompok miostoma paling tinggi ditemukan diempat lokasi, sedangkan kelimpahan Kryptopterus apogon ditemukan dalam jumlah paling rendah. Fluktuasi kelimpahan Ompok  miostoma relatif stabil selama bulan penangkapan kecuali sedikit menurun pada bulan April dan Oktober, sedangkan pada Ompok hypophthalmus, Kryptopterus limpok, Kryptopterus bicirrhis, Kryptopterus micronema, Kryptopterus apogon meningkat pada bulan Agustus hingga Desember. Sebaran spasial spesies ikan lais di lokasi penangkapan dipengaruhi oleh perbedaan kondisi habitat, sedangkan sebaran temproral dipengaruhi oleh perubahan musim.
Uji Efektivitas Ekstrak Buah Lerak (Sapindus rarak, D.C) sebagai Repelan Anti Nyamuk Aedes aegypti
Authors: Kelik Marmi , Zuliatus Eka
Published: October 2018

Aedes aegyptimerupakan pembawa utama penyakit DBD yang angka kejadiannya cenderung meningkat dan penyebarannya semakin meluas. Upaya pengendalian vektor yang biasa dilakukan di masyarakat adalah menggunakan insektisida kimiawi dan menyebabkan keracunan pada manusia. Jenis pengendalian yang aman digunakan adalah insektisida alami yang berasal dari tumbuhan, salah satunya adalah buah lerak (Sapindus rarak DC.). Tujuan dari penelitian ini adalah untuk mengetahui efektifitas repelan  ekstrak metanol  buah lerak (Sapindus rarak DC.) terhadap nyamuk Aedes aegypti. Jenis penelitian ini adalah eksperimental dengan rancangan acak lengkap menggunakan kelinci sebagai hewan uji , terdiri dari 5 perlakuan yaitu 0%,3%, 7%, 9% dan Lotion X menggunakan 3 kali pengulangan. Analisis data  dilakukan menggunakan uji Kruskal Wallis dengan p=0,05. Hasil uji Kruskal Wallismenunjukkan bahwa terdapat perbedaan jumlah nyamuk yang hinggap pada berbagai konsentrasi lotion ekstrak metanol buah lerak (Sapindus rarak DC.), ditunjukkan dengan nilai signifikansi p=0,016 (p<0,05). Simpulan  dari  penelitian ini  adalah  repelan ekstrak metanol buah lerak (Sapindus rarak DC.) efektif menolak nyamuk Aedes aegyptipada konsentrasi 7% dan 9% karena daya tolak dan daya proteksi sebesar 100% selama 6 jam.
The Role of Phosphate-Conversion Coatings in the Makeup and Sealing Ability of Casing Connections
Authors: Ernens D.. , van Riet E. J. , de Rooij M. B. , Pasaribu H. R. , van Haaften W. M. , Schipper D. J.
Published: October 2018

Phosphate-conversion coatings are widely used on (premium) casing connections for protection against corrosion. These coatings provide galling protection in conjunction with lubricant. The friction and wear that occur during makeup and subsequent load cycling strongly influence the sealing performance of the metal/metal seal. Therefore, phosphate-conversion coatings play an important role in the sealing performance of metal/metal seals. An extensive test program was set up to investigate the role of phosphate coatings during makeup and in the subsequent sealing of the metal/metal seal. With pin-on-disk, anvil-on-strip, and ring-on-ring tests, the interactions between the substrate, lubricant, and phosphate coating were investigated. A comparison was made between uncoated and coated specimens using base greases and formulated greases: API-modified lubricant and two commercially available yellow dopes. The results indicate a strong influence of the phosphate coating leading to damage-free makeup, low wear, and less dependence on the lubricant for optimal sealing ability. This is attributed to the formation of a hard and smooth dissimilar surface, the ability to adsorb the lubricant, and the generation of a transfer layer on the uncoated countersurface. It is concluded that taking the interaction with phosphates into account could enable lubricants to be tailored for sealing performance, and thus can ease the transition to environmentally friendly rated lubricants.