bluuebunny/crossref_metadata_2025 huggingface dataset:
Core Outcome Set for IgE‐mediated food allergy clinical trials and observational studies of interventions: International Delphi consensus study ‘COMFA’
Authors: Demidova Anastasia , Drewitz Karl Philipp , Kimkool Parisut , Banjanin Nikolina , Barzylovich Vladyslava , Botjes Erna , Capper India , Castor Mary Anne R. , Comberiati Pasquale , Cook Emma E. , Costa Joana , Chu Derek K. , Epstein Michelle M. , Galvin Audrey Dunn , Giovannini Mattia , Girard Frédéric , Golding Michael A. , Greenhawt Matthew , Ierodiakonou Despo , Jones Christina J. , Khaleva Ekaterina , Knibb Rebecca C. , Macit‐Çelebi Melahat Sedanur , Mack Douglas P. , Mafra Isabel , Marchisotto Mary Jane , Mijakoski Dragan , Nekliudov Nikita , Özdemir Cevdet , Patel Nandinee , Pazukhina Ekaterina , Protudjer Jennifer L. P. , Rodríguez del Rio Pablo , Roomet Jelena , Sammut Patrick , Schoos Ann‐Marie Malby , Schopfer Anita Fossaluzza , Schultz Fallon , Seylanova Nina , Skypala Isabel , Sørensen Martin , Stoleski Sasho , Stylianou Eva , Upton Julia , van de Veen Willem , Genuneit Jon , Boyle Robert J. , Apfelbacher Christian , Munblit Daniel ,   COMFA Consortium
Published: March 2024

Background

IgE‐mediated food allergy (FA) is a global health concern with substantial individual and societal implications. While diverse intervention strategies have been researched, inconsistencies in reported outcomes limit evaluations of FA treatments. To streamline evaluations and promote consistent reporting, the Core Outcome Measures for Food Allergy (COMFA) initiative aimed to establish a Core Outcome Set (COS) for FA clinical trials and observational studies of interventions.

Methods

The project involved a review of published clinical trials, trial protocols and qualitative literature. Outcomes found as a result of review were categorized and classified, informing a two‐round online‐modified Delphi process followed by hybrid consensus meeting to finalize the COS.

Results

The literature review, taxonomy mapping and iterative discussions with diverse COMFA group yielded an initial list of 39 outcomes. The iterative online and in‐person meetings reduced the list to 13 outcomes for voting in the formal Delphi process. One more outcome was added based on participant suggestions after the first Delphi round. A total of 778 participants from 52 countries participated, with 442 participating in both Delphi rounds. No outcome met a priori criteria for inclusion, and one was excluded as a result of the Delphi. Thirteen outcomes were brought to the hybrid consensus meeting as a result of Delphi and two outcomes, ‘allergic symptoms’ and ‘quality of life’ achieved consensus for inclusion as ‘core’ outcomes.

Conclusion

In addition to the mandatory reporting of adverse events for FA clinical trials or observational studies of interventions, allergic symptoms and quality of life should be measured as core outcomes. Future work by COMFA will define how best to measure these core outcomes.
Psychological predictors of vaping uptake among non‐smokers: A longitudinal investigation of New Zealand adults
Authors: Conner Tamlin S. , Teah Grace E. , Sibley Chris G. , Turner Robin M. , Scarf Damian , Mason Andre
Published: March 2024

Introduction

Demographic and health factors are known to predict vaping. Less is known about psychological predictors of vaping uptake, particularly among non‐smoking adults using longitudinal designs. We aimed to model how psychological factors related to personality and mental health predicted the likelihood of vaping uptake over time in non‐smoking adults ages 18+ using longitudinal data.

Methods

Longitudinal regression models utilised data from the 2018–2020 waves of the New Zealand Attitudes and Values Study to assess how the Big Five personality traits, mental distress and self‐control predicted who began vaping over time among non‐users (non‐vapers and non‐smokers), controlling for gender, age, ethnicity and economic deprivation.

Results

Analyses included 36,309 adults overall (ages 18 to 99; M = 51.0). The number of non‐users who transitioned into current vaping was small (transitioned from 2018 to 2019, n = 147; 0.48%; 2019 to 2020, n = 189, 0.63%). Fully adjusted models showed that adults with higher mental distress (adjusted odds ratio [aOR] 1.43; 95% confidence interval [CI] 1.09–1.88), lower self‐control (aOR 0.79; 95% CI 0.69–0.89) and higher extraversion (aOR 1.09; 95% CI 1.06–1.13) were more likely to begin vaping at the next time point compared to adults who remained non‐users. Higher neuroticism and lower conscientiousness also predicted vaping uptake in initial models, but inclusion of mental distress and self‐control superseded these traits.

Discussion and Conclusions

Psychological factors related to mental distress, impulse control and sociability predicted who was more likely to begin vaping as non‐smoking adults. Harm prevention interventions could target these factors to reduce vaping uptake in non‐smokers.
SIF formula based on exact SIF distribution for semi‐elliptical surface cracks subjected to mode I, II, III uniform loading
Authors: Takase Yasushi , Noda Nao‐Aki
Published: March 2024

The stress intensity factor (SIF) distribution of a semi‐elliptical surface crack is often used for evaluating the fatigue strength of structures. Virtually exact distributions of SIFs
can be provided along the crack front by solving the hypersingular integral equation of the body force method. In this paper, to create a very accurate SIF variation formula, the elliptical crack SIF solutions
,
,
are used and the SIF ratios
,
,
are mainly focused. Paying attention to the corner point singularity, by applying the least squares method to the ratio
,
in the whole range of parametric angle
,
and
formulas can be proposed. Instead,
formula can be proposed by applying the method of least squares to the ratio of
in the range
but applying directly to
in the range
. In this way, all of formulas proposed in this paper provide the SIFs with better than 1.0% accuracy.
Significant accrual of soil organic carbon through long‐term rice cultivation in paddy fields in China
Authors: Yang Xiaomin , Song Zhaoliang , Van Zwieten Lukas , Guo Laodong , Chen Ji , Luo Zhongkui , Wang Yidong , Luo Yu , Wang Zhengang , Wang Weiqi , Wang Jingxu , Wang Yu , Liu Cong‐Qiang , Wang Hailong
Published: March 2024

Paddy fields serve as significant reservoirs of soil organic carbon (SOC) and their potential for terrestrial carbon (C) sequestration is closely associated with changes in SOC pools. However, there has been a dearth of comprehensive studies quantifying changes in SOC pools following extended periods of rice cultivation across a broad geographical scale. Using 104 rice paddy sampling sites that have been in continuous cultivation since the 1980s across China, we studied the changes in topsoil (0–20 cm) labile organic C (LOC I), semi‐labile organic C (LOC II), recalcitrant organic C (ROC), and total SOC. We found a substantial increase in both the content (48%) and density (39%) of total SOC within China's paddy fields between the 1980s to the 2010s. Intriguingly, the rate of increase in content and density of ROC exceeded that of LOC (I and II). Using a structural equation model, we revealed that changes in the content and density of total SOC were mainly driven by corresponding shifts in ROC, which are influenced both directly and indirectly by climatic and soil physicochemical factors; in particular temperature, precipitation, phosphorous (P) and clay content. We also showed that the δ13CLOC were greater than δ13CROC, independent of the rice cropping region, and that there was a significant positive correlation between δ13CSOC and δ13Cstraw. The δ13CLOC and δ13CSOC showed significantly negative correlation with soil total Si, suggesting that soil Si plays a part in the allocation of C into different SOC pools, and its turnover or stabilization. Our study underscores that the global C sequestration of the paddy fields mainly stems from the substantial increase in ROC pool.
Comparison of migraine with left‐ versus right‐sided headache: A cross‐sectional study
Authors: Sprouse Blum Adam S. , DaSilva Lauren A. , Greenberg Michael D. , Nissenbaum Alexander J. , Shapiro Robert E. , Littenberg Benjamin
Published: March 2024

Objective

The goal of this study was to clarify whether clinical differences exist between patients with migraine who experience headache that is typically left‐sided (“left‐migraine”) versus right‐sided (“right‐migraine”) during attacks.

Background

Migraine has been associated with unilateral headache for millennia and remains a supportive trait for the clinical diagnosis of migraine of the International Classification of Headache Disorders. It is currently unknown why headache in migraine is commonly unilateral, and whether headache‐sidedness is associated with other clinical features.

Methods

This is a cross‐sectional study comparing left‐ versus right‐migraine using all available intake questionnaires of new patients evaluated at an academic tertiary headache center over a 20‐year period. Eligibility was based on patient written responses indicating the typical location of headache during attacks. In our analyses, the side of headache (left or right) was the predictor variable. The outcomes included various migraine characteristics and psychiatric comorbidities.

Results

We identified 6527 patients with migraine, of which 340 met study eligibility criteria. Of these, 48.8% (166/340) had left migraine, and 51.2% (174/340) had right migraine. When comparing patients with left‐ versus right‐migraine, patients with left migraine experienced 3.6 fewer headache‐free days (95% confidence interval [CI] 1.3–5.9; p = 0.002) and 2.4 more severe headache days (95% CI 0.8–4.1; p = 0.004) in the previous 4 weeks. No significant differences in age, sex, handedness, migraine characteristics, or psychiatric comorbidities were identified between the two groups.

Conclusions

Patients with migraine with typically left‐sided headache during attacks reported a higher burden of headache frequency and severity than those with typically right‐sided headache during attacks. These findings may have implications for our understanding of migraine pathophysiology, treatment, and clinical trial design.
Embodied GHG of missing middle: Residential building form and strategies for more efficient housing
Authors: Rankin Keagan Hudson , Arceo Aldrick , Isin Kaan , Saxe Shoshanna
Published: March 2024

This research addresses two critical problems facing communities today: the growing demand for housing and the need to reduce material consumption to mitigate the impacts of climate change. Material production and use accounts for more than 25% of annual global greenhouse gas (GHG) emissions and must be reduced to meet the Paris Climate Agreement's 2°C target. At the same time, increasing urban populations are accelerating the demand for housing and construction materials. Strategies for supplying more materially efficient housing are urgently needed. Here, we quantify the impact of residential form on embodied emissions. Specifically, we look at the reduction potential of missing middle (low‐rise multi‐unit) housing, compare missing middle to single‐family and mid/high‐rise buildings, and identify opportunities for optimizing efficiency within forms. Forty‐two new material quantifications are calculated using an ontology based on MasterFormat and UniFormat. Minimum, maximum, and most likely GHG emissions factors are used to convert material mass to CO2eq. We observe embodied GHG of missing middle buildings varying between 5540 and 39,600 kgCO2eq/bedroom. On average, multi‐unit missing middle buildings have significantly lower embodied GHG per bedroom than single‐family and mid/high‐rise buildings, but variability within forms is greater than between forms, indicating a large potential to reduce embodied GHG through building design. Best‐in‐class design strategies include reducing substructure size and indoor parking, limiting mid/high‐rise slab thickness, and choosing low‐GHG insulation products. Building missing middle homes in the 1st quartile of embodied GHG efficiency with minimum insulation emissions factors could reduce future embodied residential emissions in Ontario, Canada by 46.7%.
Effects of repeated tasting sessions on acceptability, emotional responses, and purchasing behaviors of waste‐to‐value‐added SCOBY (symbiotic culture of bacteria and yeast) ice cream
Authors: Mehta Annu , Serventi Luca , Kumar Lokesh , Torrico Damir D.
Published: March 2024

This study investigated the effects of repeated exposure on acceptability, emotional responses, and purchase intention of a novel symbiotic culture of bacteria and yeast (SCOBY) ice cream, compared to a control (no extra additives) and a guar gum ice cream sample, using three sessions: a survey (SCOBY information) and two tasting sessions (repeated‐exposure effect). Participants initially conducted blind evaluations of all samples, followed by an informed tasting. The blind tasting sessions evoked high arousal emotions for the SCOBY ice cream and positive emotions for the control and guar gum samples. The second session showed a rise in liking for sweetness (5.6–6.5) and texture (5.6–6.7) of the SCOBY samples. Sensory attributes such as flavor (odds ratio = 1.7) and texture (odds ratio = 1.7), coupled with positive emotions such as “happy” (odds ratio = 3.8), “pleasant” (odds ratio = 0.4), and “interested” (odds ratio = 3.8) affected purchase intention. The findings of this study provide valuable insights into participants' liking and emotional responses during repeated exposures to stimuli.

Practical Applications

The study's findings show that repeated exposure to novel products enhances consumer acceptance and emotional responses, challenging the current formats of traditional sensory studies. This implies that the introduction of novel products can be successful with repeated tasting exposure strategies. The focus on improving familiarity with sensory attributes, especially flavor and texture, can positively impact purchase intention. This insight can guide product positioning, marketing campaigns, and flavor development efforts, encouraging the successful integration of innovative products into the market.
Multitask deep learning for prediction of microvascular invasion and recurrence‐free survival in hepatocellular carcinoma based on MRI images
Authors: Wang Fang , Zhan Gan , Chen Qing‐qing , Xu Hou‐yun , Cao Dan , Zhang Yuan‐yuan , Li Yin‐hao , Zhang Chu‐jie , Jin Yao , Ji Wen‐bin , Ma Jian‐bing , Yang Yun‐jun , Zhou Wei , Peng Zhi‐yi , Liang Xiao , Deng Li‐ping , Lin Lan‐fen , Chen Yen‐wei , Hu Hong‐jie
Published: March 2024

Background and Aims

Accurate preoperative prediction of microvascular invasion (MVI) and recurrence‐free survival (RFS) is vital for personalised hepatocellular carcinoma (HCC) management. We developed a multitask deep learning model to predict MVI and RFS using preoperative MRI scans.

Methods

Utilising a retrospective dataset of 725 HCC patients from seven institutions, we developed and validated a multitask deep learning model focused on predicting MVI and RFS. The model employs a transformer architecture to extract critical features from preoperative MRI scans. It was trained on a set of 234 patients and internally validated on a set of 58 patients. External validation was performed using three independent sets (n = 212, 111, 110).

Results

The multitask deep learning model yielded high MVI prediction accuracy, with AUC values of 0.918 for the training set and 0.800 for the internal test set. In external test sets, AUC values were 0.837, 0.815 and 0.800. Radiologists' sensitivity and inter‐rater agreement for MVI prediction improved significantly when integrated with the model. For RFS, the model achieved C‐index values of 0.763 in the training set and ranged between 0.628 and 0.728 in external test sets. Notably, PA‐TACE improved RFS only in patients predicted to have high MVI risk and low survival scores (p < .001).

Conclusions

Our deep learning model allows accurate MVI and survival prediction in HCC patients. Prospective studies are warranted to assess the clinical utility of this model in guiding personalised treatment in conjunction with clinical criteria.
Identifying the impact of audit and feedback on the professional role of the nurse and psychological well‐being: An integrative systematic review
Authors: Michl Gabriella , Bail Kasia , Turner Murray , Paterson Catherine
Published: March 2024

This systematic review aimed to critically synthesis evidence to identify the impact that audit and feedback processes have on the professional role of the nurse and psychological well‐being. Little is known about the extent to which audit and feedback processes can positively or negatively impact the professional role of the nurse and psychological well‐being. An integrative systematic review was conducted. Covidence systematic review software was used to manage the screening process. Data extraction and methodological quality appraisal were conducted in parallel, and a narrative synthesis was conducted. Nurse participation and responsiveness to audit and feedback processes depended on self‐perceived motivation, content, and delivery; and nurses viewed it as an opportunity for professional development. However, audit was reported to negatively impact nurses' psychological well‐being, with impacts on burnout, stress, and demotivation in the workplace. Targeting framing, delivery, and content of audit and feedback is critical to nurses' satisfaction and successful quality improvement.
The effect of socioeconomic status on pediatric heart transplant outcomes at a single institution between 2013 and 2022
Authors: Armstrong Allison , Liang Jane W. , Char Danton , Hollander Seth A. , Pyke‐Grimm Kimberly A.
Published: March 2024

Background

Disparities in pediatric heart transplant outcomes based on socioeconomic status (SES) have been previously observed. However, there is a need to reevaluate these associations in contemporary settings with advancements in transplant therapies and increased awareness of health disparities. This retrospective study aims to investigate the relationship between SES and outcomes for pediatric heart transplant patients.

Methods

Data were collected through a chart review of 176 pediatric patients who underwent first orthotopic heart transplantation (OHT) at a single center from 2013 to 2021. The Area Deprivation Index (ADI), a composite score based on U.S. census data, was used to quantify SES. Cox proportional hazards models and generalized linear models were employed to analyze the association between SES and graft failure, rejection rates, and hospitalization rates.

Results

The analysis revealed no statistically significant differences in graft failure rates, rejection rates, or hospitalization rates between low‐SES and high‐SES pediatric heart transplant patients for our single‐center study.

Conclusion

There may be patient education, policies, and social resources that can help mitigate SES‐based healthcare disparities. Additional multi‐center research is needed to identify post‐transplant care that promotes patient equity.
Pharmacokinetics of Envarsus in pediatric kidney transplant recipients – phase 1 pilot conversion study
Authors: Kim Jon Jin , Lawless Laura , Marshall David , Maxted Andrew , Lunn Andrew , Mallik Meeta , Williams Alun
Published: March 2024

Introduction

Tacrolimus is the standard immunosuppressant for pediatric kidney transplants and is routinely administered twice daily (BD‐tac). Envarsus (LCP‐tac), an extended‐release formulation, is approved for adults but not for pediatric patients.

Methods

We conducted a pilot open‐label phase 1 study in stable pediatric kidney transplant recipients (age < 18 at the time of study). Our primary objective was to compare the pharmacokinetics (Pk) of LCP‐tac versus BD‐tac. We conducted two 24‐h Pk studies: pre‐conversion (BD‐tac) and 4 weeks post‐conversion to LCP‐tac. Patients were followed for 6 months, with the option to continue LCP‐tac.

Results

Five patients completed the study, with no returns to BD‐tac. Median age was 15 years (range 11–17). LCP‐tac exhibited an extended‐release profile versus the bimodal profile of BD‐tac. Time to maximum concentration was delayed (5 h vs. 1 h), and maximum concentration was lower (9.9 ng/mL vs. 14.4 ng/mL). Tacrolimus area under the curve (24 h) was comparable (141 ± 46.5 ng/mL vs. 164 ± 27.8 ng/mL). No new safety concerns arose. There were no rejection and no difference in eGFR at the study's end (1.5 mL/min/1.73 m2, range − 1.7 to 2.3 mL/min/1.73 m2). Concentration/dose ratio was higher in LCP‐tac (1.8 ± 0.64 vs. 0.8 ± 0.39). The final conversion ratio was 0.6 (BD‐tac: LCP‐tac).

Conclusion

Our pilot study confirms the extended‐release Pk profile and improved absorption of LCP‐tac compared to BD‐tac. A larger study is needed to further evaluate the population Pk characteristics in children.
Mitochondrial targeting improves the selectivity of singlet‐oxygen cleavable prodrugs in NMIBC treatment
Authors: Rahman Kazi Md Mahabubur , Bist Ganesh , Kumbham Soniya , Foster Barbara A. , Woo Sukyung , You Youngjae
Published: March 2024

Mitochondria play an essential role in cancer treatment by providing apoptotic signals. Hexyl aminolevulinate, an FDA‐approved diagnosis for non‐muscle invasive bladder cancer, induces the production of protoporphyrin IX (PpIX) preferentially by mitochondria in cancer cells. Photosensitizer PpIX upon illumination can release active chemotherapy drugs from singlet oxygen‐activatable prodrugs. Prodrugs placed close enough to PpIX formed in mitochondria can improve the antitumor efficiency of PpIX‐PDT. The preferred uptake of prodrugs by cancer cells and tumors can further enhance the selective damage of cancer cells over non‐cancer cells and surrounding normal tissues. Mitochondriotropic prodrugs of anticancer drugs, such as paclitaxel and SN‐38, were synthesized using rhodamine, a mitochondrial‐targeting moiety. In vitro, the mitochondrial targeting helped achieve preferential cellular uptake in cancer cells. In RT112 cells (human bladder cancer cells), intracellular prodrug concentrations were 2–3 times higher than the intracellular prodrug concentrations in BdEC cells (human bladder epithelial cells), after 2 h incubation. In an orthotopic rat bladder tumor model, mitochondria‐targeted prodrugs achieved as much as 34 times higher prodrug diffusion in the tumor area compared to the nontumor bladder area. Overall, mitochondria targeting made prodrugs more effective in targeting cancer cells and tumors over non‐tumor areas, thereby reducing nonspecific toxicity.
AnWRKY29 and AnHSP90 synergistically modulate trehalose levels in a desert shrub leaves during osmotic stress
Authors: Wang Shuyao , Hao Xin , Liu Yahui , Chen Yingying , Qu Yue , Wang Zhaoyuan , Shen Yingbai
Published: March 2024

Trehalose, a biological macromolecule with osmotic adjustment properties, plays a crucial role during osmotic stress. As a psammophyte, Ammopiptanthus nanus relies on the accumulation of organic solutes to respond to osmotic stress. We utilized virus‐induced gene silencing technology for the first time in the desert shrub A. nanus to confirm the central regulatory role of AnWRKY29 in osmotic stress, as it controls the transcription of AnTPS11 (trehalose‐6‐phosphate synthase 11). Further investigation has shown that AnHSP90 may interact with AnWRKY29. The AnHSP90 gene is sensitive to osmotic stress, underscoring its pivotal role in orchestrating the response to such adverse conditions. By directly targeting the W‐box element within the AnTPS11 promoter, AnWRKY29 effectively enhances the transcriptional activity of AnTPS11, which is facilitated by AnHSP90. This discovery highlights the critical role of AnWRKY29 and AnHSP90 in enabling organisms to adapt to and cope effectively with osmotic stress, which can be a crucial factor in A. nanus survival and overall ecological resilience. Collectively, uncovering the molecular mechanisms underlying the osmotic responses of A. nanus is paramount for comprehending and augmenting the osmotic tolerance mechanisms of psammophyte shrub plants.
Ecological restoration and artificial intelligence: whose values inform a project?
Authors: Woodrich Samuel T. , Pape Timothy
Published: March 2024

Significant attention has been given to how artificial intelligence (AI) can be utilized by society and in scientific fields in recent years. This article explores how AI tools utilized in various fields have been and can be applied to ecological restoration projects, their affiliated benefits and drawbacks, and what those tools depend on. While restoration efforts can benefit from such tools, individual and institutional values primarily drive project goals. As such, AI tools are constrained in their usefulness in restoration because they can only factor in value‐oriented variables to a certain degree. In fact, certain restoration practices may be so value‐laden that the use of AI may bias a restoration project in a manner which could lead to undesired outcomes. This article posits that AI can be integrated into ecological restoration projects, but that practitioners (and academics) should recognize the complexity of what AI tools are before they use them.
Therapeutic bronchoscopy for malignant central airway obstruction: Introduction to the EpiGETIF registry
Authors: Guibert Nicolas , Roy Pascalin , Amari Lyria , Legodec Julien , Escarguel Bruno , Fournier Clément , Wallyn Frederic , Cellerin Laurent , Lorut Christine , Usturoi Daniela , Egenod Thomas , Favrolt Nicolas , Schlossmacher Pascal , Bourinet Valerian , Loïc Perrot , Lachkar Samy , Camuset Juliette , Briault Amandine , Kessler Romain , Gut‐Gobert Christophe , Mangiapan Gilles , Carnot Nicolas , Briens Eric , Crutu Adrian , Marceau Armelle , Toublanc Bénédicte , Deslée Gaëtan , Dewolf Maxime , Dutilh Julien , Tronchetti Julie , Astoul Philippe , Vergnon Jean‐Michel , Dutau Hervé ,   the Groupe d'Endoscopie Thoracique et Interventionnel Francophone (GETIF)
Published: March 2024

Background and Objective

EpiGETIF is a web‐based, multicentre clinical database created in 2019 aiming for prospective collection of data regarding therapeutic rigid bronchoscopy (TB) for malignant central airway obstruction (MCAO).

Methods

Patients were enrolled into the registry from January 2019 to November 2022. Data were prospectively entered through a web‐interface, using standardized definitions for each item. The objective of this first extraction of data was to describe the population and the techniques used among the included centres to target, facilitate and encourage further studies in TB.

Results

Overall, 2118 patients from 36 centres were included. Patients were on average 63.7 years old, mostly male and smokers. Most patients had a WHO score ≤2 (70.2%) and 39.6% required preoperative oxygen support, including mechanical ventilation in 6.7%. 62.4% had an already known histologic diagnosis but only 46.3% had received any oncologic treatment. Most tumours were bronchogenic (60.6%), causing mainly intrinsic or mixed obstruction (43.3% and 41.5%, respectively). Mechanical debulking was the most frequent technique (67.3%), while laser (9.8%) and cryo‐recanalization (2.7%) use depended on local expertise. Stenting was required in 54.7%, silicone being the main type of stent used (55.3%). 96.3% of procedure results were considered at least partially successful, resulting in a mean 4.1 points decrease on the Borg scale of dyspnoea. Complications were noted in 10.9%.

Conclusion

This study exposes a high volume of TB that could represent a good source of future studies given the dismal amount of data about the effects of TB in certain populations and situations.
Gilaki reverse Ezafe: The two faces of a nominal linker
Authors: Kahnemuyipour Arsalan , Shabani Mansour , Taghipour Sahar
Published: March 2024

This paper examines a nominal linker (known as reverse Ezafe) in the Caspian language Gilaki. It is shown that the nominal linker in Gilaki is in fact the realization of two different morphosyntactic elements with distinct properties. In doing so, we also highlight the differences between reverse Ezafe and Ezafe, found in Persian and other Iranian languages. This study has implications for the typology of nominal linkers, leading to the conclusion that superficially similar linking elements, both within a language and across languages, may in fact have different syntactic properties and as such should be analyzed as distinct phenomena.
Metastatic cutaneous myxosarcoma in an adult horse
Authors: Rabelo Andreza A. , Maranhão Renata P. A. , de Miranda Ana Luísa S. , Ocarino Natalia M. , Amaral Camila I. , Paes Paulo R. O. , Monteiro Nathalia C. C. , Fantini Priscila
Published: March 2024

A 25‐year‐old mixed‐breed equine with separate nodular cutaneous lesions in the right thoracic limb (RTL) and right ventral abdominal region was admitted to a Veterinary Hospital in Belo Horizonte, Minas Gerais. Fine‐needle aspiration cytology was performed on the RTL lesion and superficial cervical lymph node, and the results were suggestive of a malignant neoplasm known as myxosarcoma. Due to the unfavorable prognosis, the animal was euthanized. Based on the macroscopic and microscopic findings, the diagnosis of metastatic cutaneous myxosarcoma was confirmed. Although rare, this tumor should be considered as a differential diagnosis for cutaneous neoplasms in this species.
Effects of canine influenza infection and DA2PP vaccination on the development of platelet‐associated immunoglobulins and platelet counts in dogs
Authors: Williams Maggie , Shropshire Sarah , Chornarm Nida , Brewer Melissa , Hawley Jennifer , Khorsand Matthew , Lappin Michael
Published: March 2024

Background

Immune thrombocytopenia (ITP) is commonly associated with platelet‐associated immunoglobulins (PAIg). Demonstration of PAIg can help determine etiologies for thrombocytopenia. In humans, ITP and thrombocytopenia have been associated with various vaccinations and influenza infections, respectively.

Objectives

We aimed to evaluate platelet counts and PAIg in research dogs with H3N2 and in research and client‐owned dogs routinely vaccinated for distemper, adenovirus‐2, parainfluenza, and parvovirus (DA2PP). The hypotheses were that H3N2 infection but not DA2PP vaccination would decrease platelet counts, and neither would result in the detection of PAIg.

Methods

Three pilot studies. Platelet counts and PAIg, measured by direct flow cytometry as %IgG, were evaluated in eight research Beagles following experimental infection with H3N2 (experiment 1), nine research Beagles vaccinated for DA2PP (experiment 2), and thirty client‐owned dogs vaccinated for DA2PP (experiment 3). All animals were considered healthy at the start of the experiments.

Results

Transient, self‐resolving decreases in platelet counts and increases in %IgG occurred following H3N2 infection, and one dog became thrombocytopenic and positive for PAIg. Following DA2PP vaccination, %IgG increased in research and client‐owned dogs, but only one dog was considered positive for PAIg with a concurrent increase in platelet count. Mean PAIg increased from baseline in client‐owned dogs following vaccination.

Conclusions

Transient PAIg and thrombocytopenia can occur following H3N2 infection, while routine vaccination for DA2PP in this group of dogs was not associated with the development of thrombocytopenia or clinically relevant formation of PAIg.
Supplemental Material: Progressive development of stylolites in cryptocrystalline quartz
Authors: Hou Zhaoliang , Qiu Kun-Feng , et al.
Published: March 2024

Table S1: Regional stratigraphy of western Sichuan Basin, China.
Supplemental Material: Pressure-temperature-time evolution of the Milin pelitic schists: Implications for the tectonic evolution of the eastern Indus-Yarlung suture zone, eastern Himalaya
Authors: Li Wangchao , Yin Changqing , et al.
Published: March 2024

Table S1: Results of GB + GBPQ and GB + GBAQ pressure-temperature calculations. Table S2: Monazite U-Th-Pb dating and trace-element analytical results of the studied rocks.
Uniaxial Quadrupole Order in a Magnet with Strong Biquadratic Exchange
Authors: Kokorina E. E. , Medvedev M. V.
Published: March 2024

It is shown that the temperature transition from a disordered paramagnetic state to the ground ferromagnetic state in a magnet with sufficiently strong biquadratic exchange interaction (compared to bilinear exchange) and spin S > 1 passes through an intermediate magnetically ordered phase (uniaxial quadrupole ordering). For a magnet with spin S = 3/2, a phase diagram of magnetic states in the region of large values of the biquadratic exchange is constructed in the mean-field approximation and the influence of the sequence of two phase transitions (paramagnetic state−quadrupole state and quadrupole state–ferromagnetic state) on the temperature behavior of the magnetic heat capacity and the initial magnetic susceptibility is investigated.
Weights, resistance bands, and rest days are best for tendinopathy
Authors: Saul Helen , Cassidy Samantha , Swaithes Laura , Pavlova Anastasia
Published: March 2024

The study

Pavlova AV, Shim JSC, Moss R, et al. Effect of resistance exercise dose components for tendinopathy management: a systematic review with meta-analysis.
Br J Sports Med
2023;57:1327-34.

To read the full NIHR Alert, go to:
https://evidence.nihr.ac.uk/alert/weights-resistance-bands-rest-days-best-tendinopathy/
Light-assisted patterning of salt precipitation on photovoltaic LiNbO3 substrates
Authors: Hernández-Gutiérrez Javier , Sebastián-Vicente Carlos , García-Cabañes Angel , Carrascosa Mercedes
Published: March 2024

The control of salt crystallization on a surface has important implications in many technological and industrial applications. In this work, we propose and demonstrate an optoelectrical method to define and control the spatial distribution of salt crystallization on a lithium niobate photovoltaic substrate. It is based on the bulk photovoltaic effect that generates an electric field on the illuminated regions of the crystal. The salt only crystallizes on these illuminated regions of the substrate. Single salt spots or more complicated spatial patterns, defined by the light intensity spatial distribution, have been achieved. In particular, some results have been obtained using scanning/moving laser beams, i.e., “drawing” the saline patterns. The role of light exposure time and salt concentration in the aqueous solution has been studied. The method has been checked with several salts with successful results showing its general applicability. A discussion on the possible physical mechanisms behind the method and their implication for the operation of photovoltaic platforms in other applications is also included.
Hydrodynamic stability of Poiseuille flow in a bidisperse porous medium with slip effect
Authors: Hajool Shahizlan Shakir , Harfash Akil J.
Published: March 2024

This study focuses on examining the hydrodynamic stability of an incompressible fluid flowing through a bidisperse porous medium. Specifically, the impact of slip boundary conditions on instability is investigated. The study looks at a scenario in which the Darcy theory is used for micropores and the Brinkman theory is used for macropores. An incompressible fluid is located within an unbound channel with a constant pressure gradient along its length in the system under investigation. The fluid flows laminarly along the pressure gradient, resulting in a stable parabolic velocity distribution that does not alter over time. Based on our observations, it appears that increasing the values of the slip parameter, permeability ratio, porous parameter, interaction parameter and Darcy Reynolds number leads to an improvement in the stability of the system. The spectrum behavior of eigenvalues in the Orr–Sommerfeld problem for Poiseuille flow exhibits significant sensitivity and is influenced by multiple factors, encompassing both the mathematical attributes of the problem and the specific numerical techniques utilized for approximation.
A Case of Successful Allogeneic Hematopoietic Stem Cell Transplantation in a Severely Underweight Patient with Aplastic Anemia
Authors: Banceviča Lilija , Žučenka Andrius
Published: March 2024

Allogeneic hematopoietic stem cell transplantation (alloHSTC) is considered definitive and the most effective treatment for young patients diagnosed with severe aplastic anemia. Low body mass index (BMI) is known to be associated with poorer outcomes in stem cell transplantation and higher mortality risks. Malnutrition negatively affects the patient’s ability to mobilize stem cells, therefore reducing patients’ stem cell production, although the patient’s nutritional status improvement with enteral and parenteral nutrition may reduce the risks of stem cell graft failure and graft-vs-host disease (GVHD) occurrence. The present report demonstrates a severely underweight patient with aplastic anemia and a BMI of 11 kg/m2 who was unsuccessfully treated with immunosuppressive therapy followed by alloHSTC.
Ripple-Spreading Network of China’s Systemic Financial Risk Contagion: New Evidence from the Regime-Switching Model
Authors: Zhang Beibei , Xie Xuemei , Zhou Xi
Published: March 2024

A better understanding of financial contagion and systemically important financial institutions (SIFIs) is essential for the prevention and control of systemic financial risk. Considering the ripple effect of financial contagion, we integrate the relevant spatiotemporal information that affects financial contagion and propose to use the ripple-spreading network to simulate the dynamic process of risk contagion in China’s financial system. In addition, we introduce the smooth-transition vector autoregression (STVAR) model to identify “high” and “low” systemic risk regimes and set the relevant parameters of the ripple-spreading network on this basis. The results show that risk ripples spread much faster in high than in low systemic risk regimes. However, systemic shocks can also trigger large-scale risk contagion in the financial system even in a low systemic risk regime as the risk ripple continues. In addition, whether the financial system is in a high or low systemic risk regime, the risk ripples from a contagion source (i.e., a real estate company) spread first to the real estate sector and the banking sector. The network centrality results of the heterogeneous ripple-spreading network indicate that most securities and banks and some real estate companies have the highest systemic importance, followed by the insurance, and finally the diversified financial institutions. Our study provides a new perspective on the regulatory practice of systemic financial risk and reminds regulators to focus not only on large institutions but also on institutions with strong ripple capacity.
Supplementary Figure 2 from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer
Authors: Marquez-Palencia Mauricio , Reza Herrera Luis , Parida Pravat Kumar , Ghosh Suvranil , Kim Kangsan , Das Nikitha M. , Gonzalez-Ericsson Paula I. , Sanders Melinda E. , Mobley Bret C. , Diegeler Sebastian , Aguilera Todd A. , Peng Yan , Lewis Cheryl M. , Arteaga Carlos L. , Hanker Ariella B. , Whitehurst Angelique W. , Lorens James B. , Brekken Rolf A. , Davis Anthony J. , Malladi Srinivas
Published: March 2024

Supplementary Figure 2
Supplementary Tables 1-8 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity
Authors: Awad Dominik , Cao Pham Hong Anh , Pulliam Thomas L. , Spradlin Meredith , Subramani Elavarasan , Tellman Tristen V. , Ribeiro Caroline F. , Muzzioli Riccardo , Jewell Brittany E. , Pakula Hubert , Ackroyd Jeffrey J. , Murray Mollianne M. , Han Jenny J. , Leng Mei , Jain Antrix , Piyarathna Badrajee , Liu Jingjing , Song Xingzhi , Zhang Jianhua , Klekers Albert R. , Drake Justin M. , Ittmann Michael M. , Coarfa Cristian , Piwnica-Worms David , Farach-Carson Mary C. , Loda Massimo , Eberlin Livia S. , Frigo Daniel E.
Published: March 2024

Supplementary Tables 1-8 to accompany the main text and, in particular, the materials and methods.
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Figure S3
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Figure S8
Figure S2 from Lysine Deacetylation Is a Key Function of the Lysyl Oxidase Family of Proteins in Cancer
Authors: Wu Xingxing , Li Xue , Wang Luwei , Bi Xianxia , Zhong Weihong , Yue Jicheng , Chin Y. Eugene
Published: March 2024

TMT mass spectrometric identification of LOXL2-dependent deacetylation sites. Soft MoMo (motif-x algorithm) was used to analysis the model of sequences constituted with amino acids in specific positions of modify-21-mers (10 amino acids upstream and downstream of the site) in all protein sequences. And all the database protein sequences were used as background database parameter. Minimum number of occurrences was set to 20. Emulate original motif-x was ticked, and other parameters with default. In the enrichment heatmap, red means amino acid is positively enriched, green means amino acid is negatively enriched.
Table S6 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
Authors: Malta Tathiane M. , Sabedot Thais S. , Morosini Natalia S. , Datta Indrani , Garofano Luciano , Vallentgoed Wies , Varn Frederick S. , Aldape Kenneth , D'Angelo Fulvio , Bakas Spyridon , Barnholtz-Sloan Jill S. , Gan Hui K. , Hasanain Mohammad , Hau Ann-Christin , Johnson Kevin C. , Cazacu Simona , deCarvalho Ana C. , Khasraw Mustafa , Kocakavuk Emre , Kouwenhoven Mathilde C.M. , Migliozzi Simona , Niclou Simone P. , Niers Johanna M. , Ormond D. Ryan , Paek Sun Ha , Reifenberger Guido , Sillevis Smitt Peter A. , Smits Marion , Stead Lucy F. , van den Bent Martin J. , Van Meir Erwin G. , Walenkamp Annemiek , Weiss Tobias , Weller Michael , Westerman Bart A. , Ylstra Bauke , Wesseling Pieter , Lasorella Anna , French Pim J. , Poisson Laila M. , Woehrer Adelheid , Lowman Allison K , deCarvalho Ana C , Castro Ana Valeria , Transou Andrea , Brodbelt Andrew R , Hau Ann-Christin , Lasorella Anna , Golebiewska Anna , Walenkamp Annemiek , Molinaro Annette M , Iavarone Antonio , Ismail Azzam , Westerman Bart A , Ylstra Bauke , Bock Christoph , Ormond D. Ryan , Brat Daniel J , Kocakavuk Emre , Van Meir Erwin G , Barthel Floris P , Varn Frederick S , D'Angelo Fulvio , Finocchiaro Gaetano , Rao Ganesh , Zadeh Gelareh , Reifenberger Guido , ngNg Ho Keu , Kim Hoon , Noushmehr Houtan , Miletic Hrvoje , Gan Hui K , Datta Indrani , Rock Jack , Snyder James M , Huse Jason T , Connelly Jennifer M , Barnholtz-Sloan Jill S , Niers Johanna M , deGroot John F , Akdemir Kadir C , Kannan Kasthuri S , Ligon Keith L , Aldape Kenneth , Bulsara Ketan R , Johnson Kevin C , Alfaro Kristin D , Poisson Laila M , Garofano Luciano , Stead Lucy F , Nasrallah MacLean P , Smits Marion , van den Bent Martin J , Kouwenhoven Mathilde CM , Weller Michael , Hasanain Mohammad , Khasraw Mustafa , Gould Peter V , Smitt Peter A Sillevis , LaViolette Peter S , Tatman Philip D , Wesseling Pieter , French Pim J , Beroukhim Rameen , Verhaak Roel G.W. , Migliozzi Simona , Niclou Simone P , Bakas Spyridon , Kalkanis Steven , Paek Sun Ha , Short Susan C , Ghazaleh Tabatabai , Malta Tathiane M , Sabedot Thais S , Weiss Tobias , Walbert Tobias , Baid Ujjwal , Vallentgoed Wies , Yung W. K. Alfred , Verhaak Roel G.W. , Iavarone Antonio , Noushmehr Houtan
Published: March 2024

Table S6: Deconvolution cell proportions and probe-signature matrix
S6A: Methylcibersort cell proportions
S6B: Methylcibersort cell reference mixture
Table S3 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
Authors: Malta Tathiane M. , Sabedot Thais S. , Morosini Natalia S. , Datta Indrani , Garofano Luciano , Vallentgoed Wies , Varn Frederick S. , Aldape Kenneth , D'Angelo Fulvio , Bakas Spyridon , Barnholtz-Sloan Jill S. , Gan Hui K. , Hasanain Mohammad , Hau Ann-Christin , Johnson Kevin C. , Cazacu Simona , deCarvalho Ana C. , Khasraw Mustafa , Kocakavuk Emre , Kouwenhoven Mathilde C.M. , Migliozzi Simona , Niclou Simone P. , Niers Johanna M. , Ormond D. Ryan , Paek Sun Ha , Reifenberger Guido , Sillevis Smitt Peter A. , Smits Marion , Stead Lucy F. , van den Bent Martin J. , Van Meir Erwin G. , Walenkamp Annemiek , Weiss Tobias , Weller Michael , Westerman Bart A. , Ylstra Bauke , Wesseling Pieter , Lasorella Anna , French Pim J. , Poisson Laila M. , Woehrer Adelheid , Lowman Allison K , deCarvalho Ana C , Castro Ana Valeria , Transou Andrea , Brodbelt Andrew R , Hau Ann-Christin , Lasorella Anna , Golebiewska Anna , Walenkamp Annemiek , Molinaro Annette M , Iavarone Antonio , Ismail Azzam , Westerman Bart A , Ylstra Bauke , Bock Christoph , Ormond D. Ryan , Brat Daniel J , Kocakavuk Emre , Van Meir Erwin G , Barthel Floris P , Varn Frederick S , D'Angelo Fulvio , Finocchiaro Gaetano , Rao Ganesh , Zadeh Gelareh , Reifenberger Guido , ngNg Ho Keu , Kim Hoon , Noushmehr Houtan , Miletic Hrvoje , Gan Hui K , Datta Indrani , Rock Jack , Snyder James M , Huse Jason T , Connelly Jennifer M , Barnholtz-Sloan Jill S , Niers Johanna M , deGroot John F , Akdemir Kadir C , Kannan Kasthuri S , Ligon Keith L , Aldape Kenneth , Bulsara Ketan R , Johnson Kevin C , Alfaro Kristin D , Poisson Laila M , Garofano Luciano , Stead Lucy F , Nasrallah MacLean P , Smits Marion , van den Bent Martin J , Kouwenhoven Mathilde CM , Weller Michael , Hasanain Mohammad , Khasraw Mustafa , Gould Peter V , Smitt Peter A Sillevis , LaViolette Peter S , Tatman Philip D , Wesseling Pieter , French Pim J , Beroukhim Rameen , Verhaak Roel G.W. , Migliozzi Simona , Niclou Simone P , Bakas Spyridon , Kalkanis Steven , Paek Sun Ha , Short Susan C , Ghazaleh Tabatabai , Malta Tathiane M , Sabedot Thais S , Weiss Tobias , Walbert Tobias , Baid Ujjwal , Vallentgoed Wies , Yung W. K. Alfred , Verhaak Roel G.W. , Iavarone Antonio , Noushmehr Houtan
Published: March 2024

Table S3A/B/C/D: Clinical summary of GLASS epigenomic samples
S3A: Clinical summary of IDHmut patients who switched from GCIMP-high to GCIMP-low
S3B: Clinical summary of IDHmut and IDHwt patients with known hypermutator status
S3C: Clinical summary of IDHmut and IDHwt patients with known treatment information
S3D: Clinical summary of IDHmut patients with known treatment information
Supplementary Figure2 from Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma
Authors: Hosni Sana , Kilian Viola , Klümper Niklas , Gabbia Daniela , Sieckmann Katharina , Corvino Dillon , Winkler Anja , Saponaro Miriam , Wörsdörfer Karin , Schmidt Doris , Hahn Oliver , Zanotto Ilaria , Bertlich Marina , Toma Marieta , Bald Tobias , Eckstein Markus , Hölzel Michael , Geyer Matthias , Ritter Manuel , Wachten Dagmar , De Martin Sara , Alajati Abdullah
Published: March 2024

Supplementary Figure2
Table S1 from Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition
Authors: Fang Liang , Zhang Li , Wang Mengran , He Yuhao , Yang Jiao , Huang Zengjin , Tan Ying , Fang Ke , Li Jun , Sun Zhiyuan , Li Yanping , Tang Yisen , Liang Weizheng , Cui Huanhuan , Zhu Qionghua , Wu Zhe , Li Yiming , Hu Yuhui , Chen Wei
Published: March 2024

Table S1. The list of oligos used in the study