bluuebunny/crossref_metadata_2025 huggingface dataset:
Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson’s Disease
Authors: Cayir Salih , Tezel Melike , Matuskey David
Published: September 2024

Objective

Social factors can influence the brain’s dopaminergic function. This study investigated the relationship between socioenvironmental factors and dopamine transporter (DaT) availability in healthy individuals (n = 74) and those with Parkinson’s disease (PD) (n = 240).

Methods

All single photon emission computed tomography (SPECT) DaT data and clinical data used in this study were obtained from the Parkinson’s Progression Markers Initiative (PPMI) dataset. Socioenvironmental data was obtained from Social Explorer analyses of the American Community Survey (2014-2018) using the residential ZIP codes of the subjects available in the PPMI dataset.

Results

Participants resided in 302 ZIP code tabulation areas across 38 U.S. states. In healthy individuals, DaT signals were significant and negatively correlated in the caudate with median household income (r = −0.27, P = 0.02) and educational level of the living area (r = −0.23, P = 0.04), but not significant in the putamen (r = −0.21, P = 0.08; r = −0.11, P = 0.37 respectively). Also, there was a significant positive correlation between DaT signals in caudate and poverty rates (r = 0.29, P = 0.01), but not in the putamen (r = 0.16, P = 0.19) in healthy subjects. No significant associations were observed in the PD group for any variables.

Conclusion

The study findings suggest that socioenvironmental factors, such as median household income, education level, and poverty rate, are significantly associated with DaT availability in the caudate of healthy individuals but not in those with PD. This indicates that PD might disrupt the connection between the social environment and dopaminergic function. These results underscore the importance of considering socioenvironmental variables when studying dopaminergic function in the human brain.
Job Search Interventions for Long-Term Unemployed Job Seekers: Comparing Approaches to Effective Support
Authors: Basbug Gokce , Sharone Ofer
Published: September 2024

Drawing from the psychology of working and social resilience frameworks, this study introduces a novel intervention program to address the complex needs of long-term unemployed individuals. We examine the effectiveness of this novel intervention with a randomized, controlled field experiment where we test two versions of this program: one-on-one coaching and group coaching. Our findings show that long-term unemployed job seekers who received either form of coaching had higher reemployment rates and lower levels of self-blame than a control group that did not receive any support. Our in-depth interviews with group and one-on-one support receivers reveal that each type of support helped the long-term unemployed in distinct ways. Our findings suggest that a combination of group and one-on-one coaching to assist long-term unemployed individuals would help diminish the self-blame associated with unemployment and foster reemployment.
The (reverse) paradox of lupus anticoagulant: A case report
Authors: Kalyani Hiren , Goyal Mayank , Banavathu Tejaswee , Pandey Swetal , Rath Prasan Deep
Published: September 2024

Introduction

Systemic Lupus Erythematosus (SLE) is often associated with antiphospholipid syndrome (APS), which manifests as recurrent thrombotic events or obstetric complications in presence of antiphospholipid antibodies. Hereby we present a case of a child who presented with low grade fever, superficial thrombophlebitis with mucosal bleeding and was diagnosed as Lupus Anticoagulant Hypoprothrombonemia Syndrome (LAHS).

Case

A 7-year-old girl was hositalized with complaints of fever and spontaneous bleeding from gums and epistaxis. On examination, she had multiple small tender nodular lesions with greenish hue of overlying skin suggesting superficial thrombophlebitis and mild non-tender hepatosplenomegaly. Her coagulogram revealed normal platelet counts and deranged PT and APTT. ESR and CRP were raised. Serology for viral infections, blood and urine cultures were negative. Patient had persistent coagulopathy, mucosal bleeding and low-grade fever despite supportive treatment. She was tested for anti-nuclear antibodies (ANA) in view of suspicion of autoimmune process. ANA was positive in high titer with speckled pattern on indirect immunofluorescence. Mixing studies showed correction of PT and non-correction of APTT. PT based factors were normal except for prothrombin (FII) which was low and remained low despite dilution. APTT based factors (FVIII and FIX) were low but corrected on dilution. This was suggestive of prothrombin deficiency and a presence of a nonspecific inhibitor of APTT pathway (likely lupus anticoagulant). Presence of antiprothrombin antibodies established the diagnosis of LAHS. ENA profile was positive for SmD1, Ro60 and Ku. Complement levels were low. Direct Coomb’s test was positive but there was no evidence of hemolysis. Lupus anticoagulant by DRVVT and anti-cardiolipin antibodies by ELISA were positive. Patient was diagnosed as Systemic Lupus Erythematosus with Lupus Anticoagulant Hypoprothrombinemia Syndrome. She was treated with IV methylprednisolone. Patient showed significant improvement in form of resolution of fever, mucosal bleeding, correction of deranged INR and reversal of hypocomplementemia. She was discharged on hydroxychloroquine, mycophenolate mofetil and tapering doses of prednisolone. On follow up, child was doing well and her prothrombin time and complement levels had normalized. Low dose aspirin was aspirin was added for thromboprophylaxis.
Book review: Sabine Kuhlmann, Benoît Paul Dumas and Moritz Heuberger (Eds.), The Capacity of Local Governments in Europe: Autonomy, Responsibilities and Reforms
Authors: Arkorful Vincent Ekow
Published: September 2024

Sabine Kuhlmann, Benoît Paul Dumas and Moritz Heuberger (Eds.), The Capacity of Local Governments in Europe: Autonomy, Responsibilities and Reforms. Palgrave MacMillan, 2022, xi + 121 pp. EUR 39.99, ISBN: 9783031079610 (Hardback). https://doi.org/10.1007/978-3-031-07962-7
Family Communication With Children and Adolescents Post Parental Loss in Road Traffic Accidents: A Qualitative Study
Authors: Anupama V  , Hirisave Uma , Devi Bhagavatula Indira
Published: September 2024

Background:

Traumatic parental loss during childhood and adolescence can have long-lasting effects on the developmental trajectory of youngsters. While there is some literature on the advantages of positive family communication fostering better adjustment in bereaved children and adolescents, patterns of family communication post parental loss have not received much attention. An understanding of these patterns can pave the way for more holistic interventions in this vulnerable group. The aim of the study was to explore parental loss-related communication in families of children and adolescents who have lost a parent to a road traffic accident.

Method:

The study was carried out in a tertiary hospital setting in Bengaluru. The sample comprised of 24 children and 17 surviving parents. The study employed a qualitative research design. Semi-structured in-depth interviews were conducted with surviving parents/caregivers and the children/adolescents. The interviews were analysed by using inductive thematic analysis.

Results:

The themes generated from the semi-structured interviews highlighted patterns of communication in parentally bereaved families. Four major themes emerged from the semi-structured interviews – mode of getting to know about the death, disclosure regarding the death, discussion regarding the death and individual needs related to communication.

Conclusions:

Communication regarding parental loss as a result of road traffic accidents in the family context seems to be desirable and may enable healthy grieving in youngsters. Short-term interventions aimed at enhancing family communication patterns following traumatic parental loss need to be developed in the Indian context.
Job Service Specialists’ Lifelong Learning Experience in Taiwan: A Qualitative Study
Authors: Lee Ya-Hui , Wang Yi-Fen , Cha Hsien-Ta
Published: September 2024

Lifelong learning is a key element that helps adults undergo and adapt to different career stages. This study analyzed job service specialists’ lifelong learning experience of successfully matching the needs between job seekers and employers. The researchers adopted the qualitative research method and conducted semi-structured in-depth interviews with 11 outstanding-performing job service specialists to collect their learning experiences. The findings were that: (a) Job service specialists improve their professional competencies through formal education (Bachelor’s and Master’s degrees), non-formal education (obtaining licenses and participating in training programs), and informal learning (self-directed learning and seeking others’ experiences). (b) Job service specialists’ duties include understanding job seekers’ backgrounds, needs, motivations, expectations, career plans, and previous training experiences; job application assistance; and regular follow-ups. (c) The greatest difficulties job service specialists encounter are insufficient understanding of job seekers’ physiological and psychological characteristics and job seekers’ and employers’ needs. (d) Job service specialists can effectively match jobs for job seekers and fulfill employers’ needs by learning continuously in workplaces. These results can provide a reference for government agencies to design continuing education programs for job service specialists to promote their professional competencies.
Design and experiment of a crawling-inchworm-type self-tuned dynamic vibration absorber based on silicone gel materials
Authors: Yang Ji-Hou , Chen De-Hai , Yang Xiao-Dong
Published: September 2024

Based on the different body configurations caused by varying head-to-tail distances exhibited by crawling inchworms during locomotion, this paper proposes a crawling-inchworm-type self-tuned dynamic vibration absorber (DVA) based on silicone gel materials for reducing low-frequency vibration. The proposed DVA was designed and developed by employing a magnetic hanging design with movable features, a span adjustment design with an embedded stepper motor, and a real-time control design using a microcontroller. First, a finite element simulation model was established to analyze the main structure of the self-tuned DVA using the finite element method. The frequency-shifting characteristics of the absorber were obtained by identifying the actuating modes that are sensitive to the hanging span. Second, based on the frequency-shifting characteristics of the self-tuned DVA, an absorber control system was designed by introducing a short-time Fourier transform and PID algorithm to achieve autonomous frequency adjustment of the DVA. Finally, the self-tuned absorption effects of the prototype self-tuned DVA were tested through a series of experiments, which confirmed its excellent self-tuned vibration absorption capability within the low-frequency range.
Symposium: From coming out to coming in: Roundtable conversation among Southeast Asian queer theologians
Authors: Campos Michael Sepidoza , Cornelio Jayeel , Von Marthin Elraphoma Erich , Goh Joseph N. , “Jerlo” Jaropillo Alfred Candid , Marasigan Joshua , Meneses Kristine C. , Nainggolan Irene , Pamarán Kakay , Tapia Lizette , Udampoh Amadeo Devin , Wei-Hsien Wan
Published: September 2024

Through a roundtable conversation via Zoom, teachers, pastors, and graduate students discussed the place of gender, citizenship, and faith in their identity formation and social accountability to articulate a hermeneutical lens specific to Southeast Asian contexts that shape and critique queer identities. These participants—primarily ministers, theological students, and seminary formators—engaged in organic, fluid, and multifocal turns to capture experiences that undergird the realities of women and LGBTQIQ+ people of faith in the region.
Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis
Authors: Abu Aqel Yasmin , Alnesf Aldana , Aigha Idil I. , Islam Zeyaul , Kolatkar Prasanna R. , Teo Adrian , Abdelalim Essam M.
Published: September 2024

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver. Mutations in the GCK gene have been associated with various monogenic diabetes (MD) disorders, including permanent neonatal diabetes mellitus (PNDM) and maturity-onset diabetes of the young (MODY), highlighting its importance in maintaining glucose homeostasis. Additionally, GCK gain-of-function mutations lead to a rare congenital form of hyperinsulinism known as hyperinsulinemic hypoglycemia (HH), characterized by increased enzymatic activity and increased glucose sensitivity in pancreatic β-cells. This review offers a comprehensive exploration of the critical role played by the GCK gene in diabetes development, shedding light on its expression patterns, regulatory mechanisms, and diverse forms of associated monogenic disorders. Structural and mechanistic insights into GCK’s involvement in glucose metabolism are discussed, emphasizing its significance in insulin secretion and glycogen synthesis. Animal models have provided valuable insights into the physiological consequences of GCK mutations, although challenges remain in accurately recapitulating human disease phenotypes. In addition, the potential of human pluripotent stem cell (hPSC) technology in overcoming current model limitations is discussed, offering a promising avenue for studying GCK-related diseases at the molecular level. Ultimately, a deeper understanding of GCK’s multifaceted role in glucose metabolism and its dysregulation in disease states holds implications for developing targeted therapeutic interventions for diabetes and related disorders.
Diarrhoeagenic Escherichia coli associated with childhood diarrhoea in Osun state, Nigeria
Authors: Olayinka Ademola A. , Oginni-Falajiki Ibukunoluwa O. , Okeke Iruka N. , Aboderin Aaron O.
Published: September 2024

Introduction

Diarrhoea is a major public health concern in developing countries, usually exacerbated by poor water, sanitation and hygiene but its aetiology is under-studied, particularly away from capital cities. We identified diarrhoeagenic Escherichia coli (DEC) from stools collected in Ile-Ife and Ilesa, Osun state, Nigeria and determined their antibiotic resistance profiles.

Methods

Stool samples from 167 children with diarrhoea and 334 controls under the age of 5 years were cultured for Escherichia coli and Salmonella. Bacterial isolates were identified biochemically and DEC were identified by PCR. Antimicrobial susceptibility testing was by modified Kirby-Bauer disc diffusion method in accordance with the CLSI guidelines. Data were analyzed using Chi-square and Fisher’s exact tests.

Result

Diarrhoea infection is significantly high among children under 12 months (p = 0.002), caregivers without at least primary school education (p = 0.006), breastfeeding for under 6 months (p˂0.001), and caregivers who were siblings (p = 0.004). DEC was detected in 69(41.3%) cases but only 86(25.7%) controls (p < 0.001) and more commonly recovered during the wet season (p < 0.001). Enterotoxigenic E. coli (p = 0.031), enteropathogenic E. coli (p = 0.031) and Shiga-toxin-producing E. coli (p = 0.044) were recovered more commonly from cases than controls. DEC from patients with diarrhoea were commonly resistant to sulphonamides (91.3%), trimethoprim (82.6%), and ampicillin (78.3%) but were largely susceptible to quinolones and carbapenems (97.1%).

Conclusion

Enteropathogenic, enterotoxigenic and Shiga toxin-producing E. coli are associated with diarrhoea in our setting, and show considerable resistance to first-line antimicrobials. Risk factors for DEC diarrhoea include infancy, inadequate breastfeeding and caregivers with education below primary school.
Comparing the remineralization potential of undemineralized dentin powder versus chicken eggshell powder on artificially induced initial enamel carious lesions: an in-vitro investigation
Authors: Helal Mai Badreldin , Sheta Mai Samy , Alghonemy Wafaa Yahia
Published: September 2024

Background

White spot lesions are a widespread undesirable effect, especially prevalent during fixed orthodontic treatments. The study compared the in vitro enamel remineralization potential of undemineralized dentin matrix (UDD) versus chicken eggshell powder (CESP) for artificially induced enamel lesions.

Methods

100 caries-free and sound maxillary premolars were randomly divided into four groups each contain 25 teeth: Group I (Baseline): No treatment was done to the enamel surface. Group II (Negative control ): The enamel surface of the teeth underwent demineralization using demineralizing solution to create artificial carious lesions then kept in artificial saliva. Group III (CESP treated): After demineralizing the tooth surface, the teeth have been suspended in the CESP remineralizing solution. Group IV (UDD treated): After enamel demineralization, the teeth were suspended in UDD remineralizing solution. The remineralization potential was assessed by Vickers microhardness testing, scanning electron microscopic examination (SEM), and energy dispersive X-ray (EDX).

Results

The current study demonstrated an increase in the mean microhardness of CESP and UDD-treated groups; however, It was nearer to the baseline level in the UDD group. SEM imaging revealed greater enamel remineralization in the UDD group compared to the remaining groups. The UDD group disclosed complete coverage for the prismatic enamel compared to the CESP group, which revealed a partially remineralized enamel surface. Interestingly, the Ca/P ratio increased significantly in the CESP group compared to the negative control group. In contrast, a higher significant increase in the mean Ca/P ratios was recorded in the UDD group compared to the test groups.

Conclusion

biomimetic UDD and CESP powder should be utilized to treat enamel early carious lesions. However, UDD demonstrated the most significant remineralization potential.
Uncover the anticancer potential of lycorine
Authors: Zhang Yan-Ming , Li Ting , Xu Chun-Cao , Qian Jia-Yu , Guo Hongwei , Zhang Xiaolei , Zhan Zha-Jun , Lu Jin-Jian
Published: September 2024

Background

Natural products have a long history in drug discovery. Lycorine is an alkaloid derived from Amaryllidaceae plants, demonstrating significant pharmacological potential. Lycorine and its hydrochloride salt, lycorine hydrochloride, have shown outstanding anticancer effects both in vitro and in vivo.

Purpose

This review aims to comprehensively summarize recent research advancements regarding the anticancer potential of lycorine and lycorine hydrochloride. It intends to elucidate current research limitations, optimization strategies, and future research directions to guide clinical translation.

Methods

Various databases, e.g., Web of Science, PubMed, and Chinese National Knowledge Infrastructure, are systematically searched for relevant articles using keywords such as lycorine, cancer, pharmacokinetics, and toxicity. The retrieved literature is then categorized and summarized to provide an overview of the research advancements in the anticancer potential of lycorine and lycorine hydrochloride.

Results

Lycorine and lycorine hydrochloride demonstrate significant anticancer activities against various types of cancer both in vitro and in vivo, employing diverse mechanisms such as inducing cell cycle arrest, triggering cellular senescence, regulating programmed cell death, inhibiting angiogenesis, suppressing metastasis, and modulating immune system. Furthermore, pharmacokinetic profiles and toxicity data are summarized. Additionally, this review discusses the druggability, limitations, optimization strategies, and target identification of lycorine, offering insights for future preclinical studies.

Conclusion

The anticancer effects and safety profile of lycorine and lycorine hydrochloride suggest promising potential for clinical applications. Further research on their in-depth mechanisms and optimization strategies targeting their limitations will enhance the understanding and druggability of lycorine and lycorine hydrochloride.

Graphical Abstract
Effectiveness of structured, multidisciplinary long-term care for pediatric cancer survivors: protocol of the multicenter, randomized-controlled AELKI study
Authors: Schmidt Hannah , Baust Katja , Calaminus Gabriele , Hohls Lisa , Tetzner Katharina , Griech Nicole , Haugke Henrike , Baltus Hannah , Elsner Susanne , Katalinic Alexander , Becker Hera , Cytera Chirine , Gebauer Judith , Kock-Schoppenhauer Ann-Kristin , Neumann Anke , Denzer Christian , Schündeln Michael M. , Faber Jörg , Sattler Conny , Frühwald Michael C. , Borgmann-Staudt Anja , Barnbrock Anke , Metzler Markus , Escherich Gabriele , König Inke R. , Menrath Ingo , Langer Thorsten
Published: September 2024

Background

In Germany, around 2.250 children and adolescents are diagnosed with cancer each year. Despite generally positive long-term survival rates, many patients must cope with late effects of the disease and its treatment. This highlights the need for a well-structured, long-term approach addressing both physical and mental health issues. Currently, the German healthcare system lacks such comprehensive structures. Our study aims to evaluate the effectiveness of a structured, multidisciplinary long-term approach compared to conventional “treatment as usual” (TAU).

Methods

A prospective, multicenter study with ten pediatric university clinics in Germany will be conducted. The cluster-randomization takes place at the clinic level. Children and adolescents who completed their cancer treatment at least five years ago and their parents will be eligible to participate. While the control group (CG) receives TAU, the intervention group (IG) participates in a structured program. This program includes risk-based medical treatment and psychosocial interventions tailored to each patient’s individual needs within a two-month timeframe. The primary outcome is the improvement of self-efficacy. Secondary outcomes are satisfaction with health care, improvement of health-related quality of life (HRQoL), reduction of mental health problems, and improvement of transition readiness.

Discussion

This approach has the potential to optimize the health care for individuals who survived cancer during childhood or adolescence. It addresses the challenges of overuse, underuse, and misuse of health care resources. By considering both medical and psychosocial factors and promoting increased self-efficacy, independent from parental involvement, it may facilitate a smoother transition to adult medicine and enhance adherence to lifelong aftercare. If proven successful, this approach will contribute to the integration of multidisciplinary strategies into standard healthcare practice.

Trial registration

German Clinical Trials Register DRKS00029269. Registered on December 23, 2022.
Impact of Rubber Content on Performance of Ultra-High-Performance Rubberised Concrete (UHPRuC)
Authors: Pham Thong M. , Lee Josh , Pournasiri Emad , Li Jun , Peng Zhen , Bi Kaiming , Tran Tung M.
Published: September 2024

This study investigated the effect of rubber content on the mechanical characteristics of ultra-high-performance rubberised concrete (UHPRuC). The results revealed a distinctive non-linear decrease in the dry density of UHPRuC as the rubber content increased. Notably, lower rubber content led to a columnar failure mode, while higher content (≥ 20%) exhibited a mixed failure mode with vertical cracking and diagonal fracture. Importantly, the compressive strength showed minimal reduction compared to conventional concrete, presenting a remarkable 50% mitigation of strength reduction compared to previous studies. Utilising reference concrete with robust bond strength proved highly effective in preserving strength in rubberized concrete. Despite its effectiveness in mitigating compressive strength reduction, UHPC could not effectively offset flexural strength loss, which ranged from 1.5 to 3 times that of compressive strength loss. The addition of rubber aggregate in UHPC reduced the peak flexural strength, residual strength, and flexural toughness at a similar rate, while significantly increasing the vibration decaying rate. Incorporating 40% rubber in UHPRuC reduced the eCO2 up to 37%. Our findings emphasise the importance of reference concrete with good bond strength and shows that the addition of rubber aggregate in UHPC leads to reductions in strength but increases the energy-dissipating capacity.
Dietary processed former foodstuffs for broilers: impacts on growth performance, digestibility, hematobiochemical profiles and liver gene abundance
Authors: Srikanthithasan Karthika , Gariglio Marta , Diaz Vicuna Elena , Fiorilla Edoardo , Miniscalco Barbara , Zambotto Valeria , Cappone Eleonora Erika , Stoppani Nadia , Soglia Dominga , Raspa Federica , Nery Joana , Giorgino Andrea , Sala Roser , Martínez Marínz Andrés Luis , Madrid Sanchez Josefa , Schiavone Achille , Forte Claudio
Published: September 2024

Background

The present experiment aimed to evaluate the effects of commercially processed former foodstuffs (cFF) as dietary substitutes of corn, soybean meal and soybean oil on the growth performance, apparent total tract digestibility (ATTD), hematobiochemical profiles, and liver gene abundance in broiler chickens. Two hundred one-day-old male ROSS-308 chicks were assigned to 4 dietary groups (5 replicates of ten birds per replicate) according to their average body weight (BW, 38.0 ± 0.11 g). All groups received a two-phase feeding program: starter, d 1–12 and grower, d 12–33. The control group (cFF0) was fed a standard commercial feed based on corn, soybean meal and soybean oil. The other three groups received diets in which the feed based on corn, soybean meal, and soybean oil was partially replaced with cFF at a substitution level of 6.25% (cFF6.25), 12.5% (cFF12.5) or 25% (cFF25) for the following 33 d.

Results

The growth performance data showed no differences in BW or average daily gain among groups, although the average daily feed intake decreased during the grower period (12–33 d) and over entire experimental period (1–33 d) in a linear manner as the cFF inclusion level rose (P = 0.026), positively affecting the gain to feed ratio (P = 0.001). The ATTD of dry matter of the cFF-fed groups were greater with respect to control group and increased throughout the experimental period, whereas the ATTD of ether extract linearly decreased with increasing levels of cFF-fed groups compared with control group and throughout the experimental period (P < 0.05). Additionally, a linear increase in the heterophil to lymphocyte ratio, serum cholesterol, triglycerides and alanine-aminotransferase were observed with increasing dietary levels of cFF (P < 0.05); however, no differences were observed in lipoprotein lipase or sterol regulatory element binding transcription factor gene abundance.

Conclusions

The results of this experiment demonstrate that it is possible to incorporate cFF into nutritionally balanced diets for broiler chickens, even up to 25% substitution levels, for up to 33 d without adversely impacting the overall growth performance of male broiler chickens raised under commercial conditions. Further studies are essential to validate the hematological trait findings.
Implementing healthy food policies in health sector settings: New Zealand stakeholder perspectives
Authors: Rosin Magda , Ni Mhurchu Cliona , Mackay Sally
Published: September 2024

Background

In 2016, a voluntary National Healthy Food and Drink Policy was released to improve the healthiness of food and drinks for sale in New Zealand health sector organisations. The Policy aims to role model healthy eating and demonstrate commitment to health and well-being of hospital staff and visitors and the general public. This study aimed to understand the experiences of hospital food providers and public health dietitians/staff in implementing the Policy, and identify tools and resources needed to assist with the implementation.

Methods

A maximum variation purposive sampling strategy (based on a health district’s population size and food outlet type) was used to recruit participants by email. Video conference or email semi-structured interviews included 15 open-ended questions that focused on awareness, understanding of, and attitudes towards the Policy; level of support received; perceived customer response; tools and resources needed to support implementation; and unintended or unforeseen consequences. Data was analysed using a reflexive thematic analysis approach.

Results

Twelve participants (eight food providers and four public health dietitians/staff) were interviewed; three from small (< 100,000 people), four from medium (100,000-300,000 people) and five from large (> 300,000 people) health districts. There was agreement that hospitals should role model healthy eating for the wider community. Three themes were identified relating to the implementation of the Policy: (1) Complexities of operating food outlets under a healthy food and drink policy in public health sector settings; (2) Adoption, implementation, and monitoring of the Policy as a series of incoherent ad-hoc actions; and (3) Policy is (currently) not achieving the desired impact. Concerns about increased food waste, loss of profits and an uneven playing field between food providers were related to the voluntary nature of the unsupported Policy. Three tools could enable implementation: a digital monitoring tool, a web-based database of compliant products, and customer communication materials.

Conclusions

Adopting a single, mandatory Policy, provision of funding for implementation actions and supportive tools, and good communication with customers could facilitate implementation. Despite the relatively small sample size and views from only two stakeholder groups, strategies identified are relevant to policy makers, healthcare providers and public health professionals.
Comparative clinical study of Mist Amen Fevermix and Edhec Malacure: two polyherbal products used for the treatment of uncomplicated malaria in Ghana against Artemether/Lumefantrine
Authors: Turkson Bernard K. , Amponsah Isaac K. , Agyemang Alfred Ofori , Mensah Merlin L. K. , Nketia Reinhard I. , Nkrumah Desmond , Baidoo Michael F. , Mensah Abraham Y. , Achaab Emmanuel , Accam Burnett Tetteh
Published: September 2024

The use of herbal products for the treatment of malaria, has increased globally. However, inadequate scientific studies about the safety and effectiveness of such herbal products have been raised. Also, the reduced sensitivity of the malaria parasites to artemisinin-based combination therapies is of concern. There is therefore the need for new antimalarial medications including those from alternative sources such as herbal medicinal products. In this study, a prospective, comparative parallel group randomized, clinical study was done to assess the safety and effectiveness of Mist Amen Fevermix and Mist Edhec Malacure with Artemether/Lumefantrine as control at the Tafo Government Hospital, Kumasi between July and November 2019, after Committee on Human Research, Publication and Ethics approval (CHRPE/AP/424/19). The study was conducted in accordance with Good Clinical and Laboratory Practice (GCLP) and registered with the Pan African Clinical Trials Registry with trial number PACTR202109664146698. Participant completed an informed consent form. Randomization was based on a single sequence to allocate participants to a group. SPSS version 19. One-way ANOVA test and exploratory statistics was used for data analysis. Total sample size was 150 participants with 50 on each arm of the group. Male and female patients aged 15–45 years and meet inclusion criteria with clinically established malaria were treated with Mist Amen Fevermix and Mist Edhec Malacure, at the specified doses of 45 mls (0.1063 g) and 30 mls (0.0521 g) three times daily after meals for three days. Artemether/Lumefantrine was administered at a dose of 80/480 mg/kg twice daily after meals for three days. Baseline data was taken on day 0. Patients were then followed up on Day 3, 7 and 28 to establish treatment outcomes and any side effect using a checklist for signs and symptoms and Karnofsky’s scale to assess the quality of life. Mist Amen Fevermix was effective with a cure rate of 95.89%. Mist Edhec Malacure was also effective with a cure rate of 91.87%. The cure rate of Artemether/Lumefantrine was 97.25%. Kidney and liver panels were within normal reference range at the end of the 28-day study. This study supports the use of Mist Amen Fevermix and Mist Edhec Malacure, two multi-component products as safe and effective for the treatment of uncomplicated malaria. Both products achieved a comparable clinical treatment outcome with Artemether/Lumefantrine.
Simple techniques to bypass GenAI text detectors: implications for inclusive education
Authors: Perkins Mike , Roe Jasper , Vu Binh H. , Postma Darius , Hickerson Don , McGaughran James , Khuat Huy Q.
Published: September 2024

This study investigates the efficacy of six major Generative AI (GenAI) text detectors when confronted with machine-generated content modified to evade detection (n = 805). We compare these detectors to assess their reliability in identifying AI-generated text in educational settings, where they are increasingly used to address academic integrity concerns. Results show significant reductions in detector accuracy (17.4%) when faced with simple techniques to manipulate the AI generated content. The varying performances of GenAI tools and detectors indicate they cannot currently be recommended for determining academic integrity violations due to accuracy limitations and the potential for false accusation which undermines inclusive and fair assessment practices. However, these tools may support learning and academic integrity when used non-punitively. This study aims to guide educators and institutions in the critical implementation of AI text detectors in higher education, highlighting the importance of exploring alternatives to maintain inclusivity in the face of emerging technologies.
[18F]AlF-PSMA-11 PET in diagnosing prostate cancer: a head-to-head comparison with [68Ga]Ga-PSMA-11 PET and an exploration of dual-phase scanning
Authors: Li Xiao , Yu Mingming , Yang Jian , Li Danni , Li Rou , Mao Juanli , Zuo Changjing , Liang Zeying , Li Qiang , Cheng Chao
Published: September 2024

Purpose

To evaluate the physiological distribution and tumour detection ability of [18F]AlF-PSMA-11 positron emission tomography (PET) dual-phase scans in patients with prostate cancer (PCa).

Methods

As a retrospective study, clinical and PET data of PCa patients who underwent dual-phase [18F]AlF-PSMA-11 PET of routine scan (45–50 min) and delayed scan (120 min) from November 2020 to June 2021 were collected, and physiological and pathological regions of interest were quantified to determine the time-dependent maximum standardized uptake value (SUVmax) of [18F]AlF-PSMA-11. Part of the above subjects who underwent [68Ga]Ga-PSMA-11 PET in the following 6 months were included in a head-to-head comparison. The difference with a p-value < 0.05 was defined as statistical significance. Diagnosis accuracy of primary and metastatic lesions was measured referring to the surgical findings, pathology, and follow-up imaging.

Results

[68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 were of the comparable uptake in glands in head, but the latter was of a significant lower distribution in liver and spleen. For the 25 patients initially diagnosed with prostate cancer and 3 patients with biochemical recurrence after radical surgery, the SUVmax of the primary lesions, lacrimal glands, parotid glands and submandibular glands was higher at 120 min compared to that at 45–50 min, but not a significant difference. SUVmax of the liver, spleen and bladder decreased significantly at 120 min, but the bladder SUVmax remained higher than that of primary lesions. SUVmax of the kidneys and centrum was the same in dual-phase scans. For the 31 primary lesions detected in [18F]AlF-PSMA-11 PET, both the SUVmax of the two phases kept the positive correlation with PSA, Gleason score and initial risk stratification. For the 39 distant metastatic lesions, 94.87% accuracy of routine scan and 100% accuracy of delayed scan were acquired, and 7.14% patients (2/28) benefited from the dual-phase [18F]AlF-PSMA-11 scans that revealed novel information on metastatic lesions compared to the routine scan.

Conclusion

[18F]AlF-PSMA-11 PET expanded the time window and further decreased metabolic background of [68Ga]Ga-PSMA-11 PET. The dual-phase scan of [18F]AlF-PSMA-11 PET can benefit prostate cancer diagnosis via providing more PSMA-specific information.
The coming of age of digital technologies in global health within the Indian context: a review
Authors: Dileep Vivek N.
Published: September 2024

Digital approaches have been recognized as an essential instrument for improving health systems to fulfill the Sustainable Development Goals (SDGs) and the targets for universal health care. This review article discusses policy and regulatory developments in the arena of digital health, at the global level, with a particular focus on India. It also points out that there is a need for convergence among industry, policymakers, and civil society in addressing issues of privacy and accessibility to all individuals who require affordable and quality healthcare. For the best use of digital services, inter-sectoral collaboration is necessary to integrate organizational, human, financial, and technological resources.
Review of physiological compounds and health benefits of soybean paste (doenjang): exploring its bioactive components
Authors: Park Young Kyoung , Kim Jinwon , Ryu Myeong Seon , Jeong Do-Youn , Yang Hee-Jong
Published: September 2024

This review paper explores the history, cultural significance, and functional characteristics of soybean paste (doenjang) in Korean cuisine. In particular, it covers its origins, cultural importance, production methods, functionalities, and associated risks. This review delves into the nutritional and functional aspects of fermented soybean products, focusing on compounds in soybean paste linked to health benefits, such as anticancer, anti-obesity, anti-diabetic, and antithrombotic properties. The key bioactive compounds identified in soybean paste include total phenols, total flavonoids, γ-Aminobutyric acid, vitamin B group, and vitamin E. These compounds are primarily produced through microbial fermentation, which enhances their biological activity. Additionally, the review addresses potential risks such as biogenic amines, aflatoxins, Bacillus cereus contamination, and high sodium levels, and suggests methods for mitigating these risks. By synthesizing current research, this paper aims to provide a comprehensive understanding of the physiological compounds in soybean paste and their health benefits. It also highlights the need for strategies to reduce associated risks.
Towards a definition of food processing: conceptualization and relevant parameters
Authors: Ristic Dusan , Bender Denisse , Jaeger Henry , Heinz Volker , Smetana Sergiy
Published: September 2024

There are several classifications of foods that also include the level of their processing, with NOVA classification appearing to be the most adopted. However scientific consensus is still missing on how to define, characterize and classify food processing. The classifications are typically based on the health impacts of foods and do not fully include the engineering perspective of processing, i.e., the application of physical, chemical, or biotechnological unit operations during food manufacturing, and the composition of a food product.

This review offers an engineering perspective and definition of food processing, based on the change of mass and energy, allowing distinguishment of the impacts caused by food processing during the biomass transformation to food products. The improved understanding of the causes of undesired changes in food properties could be used for nutritional public policy recommendations and would contribute to combating some of the chronic diseases related to food consumption patterns.

Proposed is the definition of “Food processing” as a sum of all intentional additions or removals of either edible matter or energy (except for any transport or for removal of inedible parts of food) between the harvest of ingredients and consumption of the product.

Graphical Abstract
Psychological assessment of violent behaviors in schizophrenic patients followed up in My EL Hassan health center of Kenitra, Morocco
Authors: Elyadini Bouchra , Chakit Miloud , Elkhatir Abdelkarim , Fitah Ilhame , Khadmaoui Abderazzak
Published: September 2024

Background

Disorders of the aggressive behavior frequently mark the entry in schizophrenia. They are not specific and very varied. The objective of this study was to assess the different risk factors associated with the manifestation of violent and aggressive behavior of schizophrenic patients who follow consultations in service of psychiatry at Kenitra, Morocco. One-hundred twenty-seven patients with schizophrenia were included, and the Modified Overt Aggression Scale (MOAS) and Positive and Negative Syndrome Scale (PANSS) were used respectively to assess the state of aggressiveness and to identify the type of psychotic symptomatology of schizophrenic patients. Clinical and sociodemographic data were obtained from all patients.

Results

The study shows that criminal history, drug addiction, motives for aggressiveness, and the moment of aggressiveness are all potential factors for aggression, and the profile of the patient likely to take the act is that of young schizophrenics under 39 years old, predominantly male, and the majority are single. Judicial history, habits toxic, and the positive psychotic symptoms are reported as the most frequently risk factors. The index of Cronbach (0.64) showed a strong connection between the four items of aggression and strong relation between MOAS and PANSS categories has been shown by independent test (p < 0.001).

Conclusion

Aggressive behavior is a frequent symptom of schizophrenia in studied population and poses many clinical challenges. It requires collaboration with the patient for handling difficult situations.
Knowledge attitude practice among oncologists and health care workers during COVID19 pandemic
Authors: Soliman Sharehan Hassan , Atef Mahinour Mohamed
Published: September 2024

Introduction

Healthcare providers should be well prepared to fight the COVID-19 pandemic and protect their patients and themselves as frontline workers. The aim of this study was to assess oncologists’ and health care workers (HCWs) knowledge, attitude, and practice in response to the COVID-19 pandemic and its impact on them.

Material and methods

This cross-sectional study was conducted among Egyptian oncologists and HCWs in the oncology department at Suez Canal University Hospitals, Egypt. Participants were reached through a Google Form questionnaire. The questionnaire was shared on social media (Facebook, Twitter, and WhatsApp) over four months, from June 1st to September 30, 2022. All physicians and HCWs in the oncology department were invited to participate in the survey. Researchers intended to enroll all physicians and HCWs within the study period.

Results

Out of the 110 participants included in the study, there was a female predominance, and the majority were oncology nurses and clinical oncologists. Knowledge with significant participants’ characteristics showed that knowledge significantly varied by age. The level of knowledge was significantly higher among participants between 30 and 40 years old (OR = 5.111; 95% CI, 1.202–21.738; P = 0.027). 65.5% of the participants had poor knowledge, with a mean ± SD of 4.9 ± 1.4. About 43.6% of the participants experienced more burnout than before the COVID-19 pandemic, with a negative emotional impact. 63.7% reported a negative financial impact due to the pandemic. 62.7% had support from their family, even though their job increases their risk of infection. 7.3% only reported a positive impact regarding their friend’s relationship.

Conclusion

COVID-19 pandemic has a negative impact on oncologists' personal and professional lives. Interventions should be implemented to lessen the negative impact and better prepare oncologists to handle future crises with greater efficiency and resilience.
In silico investigation of HCV and RNA synthesis inhibitor antibiotic drugs as potential inhibitors of SARS‑CoV‑2 main protease (Mpro)
Authors: Kishore Merusomayajula V. , Rao T. Siva , Kumari G. N. D.
Published: September 2024

Background

Since December 2019, a global crisis has unfolded with the emergence of a new strain of coronavirus known as SARS-CoV-2. This pandemic has afflicted hundreds of millions of people worldwide, resulting in millions of fatalities. In response to this urgent healthcare crisis, extensive efforts have been made to discover inhibitors of the COVID-19 virus. Given the structural similarities between SARS-CoV-2 and HCV, drugs approved by the FDA for treating HCV were selected and subjected to in silico testing against the SARS-CoV-2 virus, with Remdesivir used as the standard for validation. Drug repurposing and phytochemical testing have also been conducted to identify potential candidates capable of inhibiting or suppressing the infection caused by the coronavirus. The time constraints imposed by the pandemic necessitated the in silico analysis of existing drug molecules against the coronavirus. Eleven HCV drugs approved by the FDA, along with one RNA synthesis inhibitor antibiotic drug, were tested using the in silico method due to their structural similarities with HCV and the SARS-CoV-2 virus.

Results

Molecular docking and MD simulation studies were performed for all selected compounds. Binding energies, root-mean-square deviation, root-mean-square fluctuation, solvent-accessible surface area, radius of gyration, and molecular mechanics generalized born surface area were calculated. Based on docking and MD simulation studies all the selected compounds have shown good binding energy values with Mpro (PDB ID: 6LU7). No toxicity measurements are required for these drugs since they were previously tested prior to their approval by the FDA.

Conclusions

This study shows that FDA-approved HCV drugs can be used as for SARS-COVID-19 inhibitors.
Environmental analysis of biotechnologies for biofuels, bioplastics, and bioproducts: a greenhouse gas (GHG) emissions review
Authors: Benavides Pahola Thathiana , Balchandani Sweta , Gracida-Alvarez Ulises R.
Published: September 2024

Biotechnology and biomanufacturing development has the potential to strengthen the bioeconomy as new opportunities in many areas such as the energy, chemical, agriculture, pharmaceutical, and food industries can be unlocked. Biotechnology and biomanufacturing refer to the technologies that use microorganisms, molecular biology, metabolic engineering, and chemical processing to transform biobased resources (e.g., biomass) into new products. These microorganisms are genetically engineered in such a way that the production of new products happens more efficiently. Creating new products through biotechnology and biomanufacturing will promote shifting from a fossil-based economy to a bioeconomy. However, these new technologies will need to be evaluated from the accessibility, affordability, and sustainability point of view. In this paper, a review of recent studies evaluating the carbon footprint of biotechnologies to produce fuel, bioplastics, and bioproducts is presented. The assumptions, biogenic and coproduct credit subtraction, and co-product treatment methods in the life-cycle assessment (LCA) showed an important impact on the results of the different studies. Besides, integrated biorefineries presented an alternative to improve the environmental impact of bioproducts compared to single-product refineries.