bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomic location of colorectal cancer presents a new paradigm for its prognosis in African American patients
Authors: Wang Donghai , Agrawal Raag , Zou Shuli , Haseeb M. A. , Gupta Raavi
Published: July 2022

Among all racial groups in the U.S., African Americans (AA) have the highest incidence of and mortality from colorectal cancer (CRC). Although socioeconomic factors, as the major contributors to racial disparity of CRC, have been widely investigated, there is a dearth of information germane to understanding its biological basis. To better elucidate the clinicopathologic features we extracted demographic, clinical, pathologic and molecular features of 500 consecutive cases of CRC diagnosed at our institution which has an AA-predominant patient population (75% of all patients). We compared data from our AA patients with those of white patients both from our institution and from SEER and the published literature for meaningful comparison. AA patients were more likely to be at an advanced disease stage (25.9% vs. 20.8%, p = 0.041), have low grade tumors (89.2% vs. 77.5%, p<0.001) in cecum (18.7% vs. 16.2%, p<0.001) and <60-years-old than white patients (31.8% vs. 26.3%, p = 0.015). The frequency of KRAS mutation was higher in AA patients than in white patients (56.8% vs. 20.7%, p<0.001). Amongst subtypes of KRAS tested in CRC, codon 12 mutation is more common in AA than white patients (85.2% vs. 68.9%, p = 0.020). Compared with other racial groups, we found AA patients to have worse disease-free survival (HR = 3.682, p = 0.035). Also, AA patients with CRC in distal (sigmoid and rectum) or proximal (cecum) colon have worse overall survival than those with CRC in middle colon (HR = 2.926, p = 0.014), a finding not observed in white patients. In both racial groups, advanced stage, perforation, and hypertension were independent prognostic factors for overall survival (p<0.05). Similarly, low body-mass index at presentation, mucinous adenocarcinoma, lymphovascular invasion, perineural invasion and KRAS mutations were independent factors significantly associated with poor disease-free survival. Collectively, our data provide new insights into the roles of clinicopathologic features, especially anatomic distribution, in predicting outcomes of CRC in AA population.
Evaluation of a supported education and employment program for adolescents and young adults with mental health problems: A study protocol of the StAB project
Authors: Schniedermann Ina , Dehn Lorenz B. , Micheel Sabrina , Beblo Thomas , Driessen Martin ,   for the StAB project group
Published: July 2022

The majority of mental illnesses begins in childhood, adolescence and young adulthood before the age of 25. The transition from adolescence to adulthood is a particularly vulnerable time for adolescents with mental illness, affecting psychosocial functioning and participation in work life. Therefore, they need—in contrast to classic standard vocational interventions—a long-term, holistic and individually oriented vocational rehabilitation program. With the innovative model project "Start in education and employment (StAB)”, adolescents and young adults with mental illnesses are to be supported with regard to their vocational perspectives and participation by a new type of individualized, holistic, long-term job coaching. It follows the Individual Placement and Support (IPS) concept, as a manualized form of the Supported Employment Approach and is based on the "first place–then train" principle. In order to evaluate the effectiveness and feasibility of the StAB program, a double-centre prospective single arm evaluation study in a mixed-methods design will be conducted. The focus is on quantitative research analysing pre-post-effects of the StAB intervention in a two-year observational study. Young people between 15 and 25 years with a psychiatric diagnosis who are currently in receipt of means-tested benefits or are entitled to them will be recruited. The study will take place in two major cities in the north-western part of Germany, Bielefeld and Dortmund. We expect to contribute to gain more empirical data about the implementation of Supported Employment and Education to severely mentally ill adolescents and young adults in German settings. Moreover, these results may also provide the scientific foundation for future measures focusing the improvement of vocational rehabilitation for young people with mental illness.

The study was registered in the German Clinical Trials Register (DRKS00027576) on March 10, 2022.
“Do we even have a voice?” Health providers’ perspective on the patient accommodation strategies in Bangladesh
Authors: Kabir Md. Ruhul , Chan Kara
Published: August 2022

Objective

In a resource-constrained setting like Bangladesh, effective patient-provider communication is critical to the delivery of maternal healthcare services. Using communication accommodation theory, this study tried to understand how providers perceive, engage, and accommodate patients’ needs in maternity wards.

Methods

This qualitative exploratory study used a semi-structured interview guide to conduct in-depth face-to-face interviews of ten healthcare providers in two government-funded public health facilities in Bangladesh. The interview data were analyzed using MAXQDA 2020 software.

Results

The thematic analyses revealed that nurses and midwives faced conceivable neglect from patients and their attendees due to possible service and facility constraints, indicating their low status and control within the service operation. Despite efforts to address patients’ emotional and psychological concerns, providers appear to avoid (divergence strategy) confronting patients and their irate visitors. Unimodal convergence emerged when providers accepted patients’ arguments about the systematic inadequacy of service facilities. Providers have employed interpretability tactics to communicate medical opinions and applied nonverbal cues where necessary.

Conclusion

A lack of open communication between healthcare providers and patients necessitated various forms of accommodation. Integrated strategies addressing service restrictions and initiatives fostering patient understanding and cooperation may improve patient-provider communication.
Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels
Authors: Nishida-Tamehiro Kyoko , Kimura Akihiro , Tsubata Takeshi , Takahashi Satoru , Suzuki Harumi
Published: July 2022

NAD(P)H quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes two-electron reduction of quinone to hydroquinone by using nicotinamide adenine dinucleotide (NADPH), and functions as a scavenger for reactive oxygen species (ROS). The function of NQO1 in the immune response is not well known. In the present study, we demonstrated thatNqo1-deficient T cells exhibited reduced induction of T helper 17 cells (Th17)in vitroduring Th17(23)- and Th17(β)- skewing conditions.Nqo1-deficient mice showed ameliorated symptoms in a Th17-dependent autoimmune Experimental autoimmune encephalomyelitis (EAE) model. Impaired Th17-differentiation was caused by overproduction of the immunosuppressive cytokine, IL-10. Increased IL-10 production inNqo1-deficient Th17 cells was associated with elevated intracellular Reactive oxygen species (ROS) levels. Furthermore, overproduction of IL-10 in Th17 (β) cells was responsible for the ROS-dependent increase of c-avian musculoaponeurotic fibrosarcoma(c-maf) expression, despite the lack of dependency of c-maf in Th17(23) cells. Taken together, the results reveal a novel role of NQO1 in promoting Th17 development through the suppression of ROS mediated IL-10 production.
The new normal: Activist handmaids and cosplay choreographies in Trump’s America
Authors: Atkins Jen
Published: August 2022

Though in production before Trump’s election, streaming service Hulu’s serial adaption of The Handmaid’s Tale premiered to acclaim in April 2017. Audiences denoted parallels between ultra-conservative, fictional Gilead and the United States’ own political climate. In response to women’s issues in particular, international groups utilized the central Handmaid’s Tale image as their costume – a crimson robe, a white ‘wing’ bonnet – then occupied public spaces to protest silently. WIRED dubbed the garb the ‘Viral Protest Uniform of 2019’, while online lifestyle/culture magazine Quartz named it the ‘ultimate symbol of women’s rights’. The activists’ presence is critical to their work. Mirroring their fictional handmaid counterparts, cosplay activists employ a bowed head, a slow steady gait and equidistant spacing to evoke the harrowing restrictions Gilead’s women face – what ideologically fervent aunts call Gilead’s ‘new normal’. Activists’ physicality generates a doubleness: as they perform submissiveness and literally fall into line, they also craft solidarity via resistance. Likewise, the fiction hints at revolution, which may be why, in the #MeToo and Time’s Up era, the emancipatory potential of cosplay choreographies steeped in popular culture offer their own ‘new normal’, disrupting patriarchal paradigms modelled by the Trump administration while offering feminist fan activism as strategies that promote creative, inclusive political action.
Swedish-American Borderlands: New Histories of Transatlantic Relations, Dag Blanck and Adam Hjorthén (eds) (2021)
Authors: Johnsen Rosemary Erickson
Published: August 2022

Review of: Swedish-American Borderlands: New Histories of Transatlantic Relations, Dag Blanck and Adam Hjorthén (eds) (2021)

Minneapolis, MN: University of Minnesota Press, 363 pp.,

ISBN 978-1-51790-751-8, h/bk, $120

ISBN 978-1-51790-858-4, p/bk, $30
Un nuevo escarabeo egipcio hallado en La Fonteta (Guardamar del Segura, Alicante)
Authors: Almagro-Gorbea Martín , Lorrio Alvarado Alberto J. , López Rosendo Ester , Torres Ortiz Mariano
Published: July 2022

En este trabajo se presenta el estudio de un nuevo escarabeo hallado en el asentamiento fenicio de La Fonteta, en un contexto datado c. 720/675 a. C. Se trata, por tanto, de uno de los escarabeos más antiguos procedentes de dicho yacimiento, situado en la estratégica desembocadura del río Segura, en el se de la Península Ibérica.
Su sello ofrece una esquemática representación de la diosa Tueris con el cuchillo peseshkef. Este escarabeo se añade a otros ocho escarabeos y escaraboides hallados en La Fonteta, que complementan la dispersión de estos objetos egipcios y egiptizantes llegados a través del comercio fenicio. Todos ellos ofrecen una interesante evolución desde c. 720 a. C. hasta el final del yacimiento, c. 525 a. C., con escarabeos egipcios sustituidos por los de talleres sirios y fenicios en los ss. VII y VI a. C., con un posible ejemplar de Náucratis.
The Signature in Law: From the Thirteenth Century to the Facsimile
Authors: Mason Stephen
Published: July 2022

This book explores the judicial development of the concept of the signature from the thirteenth century to the age of the facsimile transmission. It puts the concept of the signature into a broad legal context to set out the purposes that can be attributed to a signature, and to explain the functions a signature is capable of performing. Drawing on cases from common law jurisdictions across the world, the book demonstrates that judges expanded the meaning of a signature as technologies developed and were used in unanticipated ways. Following an overview of the methods used to demonstrate proof of intent and authentication, the book considers the judicial response to the array of variations in the form that manuscript signatures have been subject over the past two hundred years, from initials, partial signatures and fingerprints, to rubber stamps and typewriting. Past judicial decision-making not only demonstrates the flexibility of the form a signature can take, but also confirms that judges had the flexibility of mind to accept the first forms of electronic signature (telex, facsimile transmission) as merely one further development without the aid of special legislation.
Teatro y sororidad: Maria Angélica Ribeiro en el campo cultural brasileño de mediados del siglo XIX
Authors: Aguilar Dornelles María Alejandra
Published: July 2022

Este ensayo analiza “Cancros Sociais” y “Um dia na opulencia” de la dramaturga brasileña Maria Angélica Ribeiro enfatizando la construcción de personajes femeninos que no temen enunciar sus anhelos y movilizar su propia agenda creando lazos de sororidad. El análisis se organiza a través de tres aspectos: la construcción de “escenas de conversación,” el desarrollo de acciones tendientes a escenificar agencia femenina y la gestualidad de los personajes para expresar con sus cuerpos una unión fraterna. Solidarias e implicadas en los debates de su tiempo, las mujeres creadas por Ribeiro ponen en acción nuevas formas de cuestionar las jerarquías sociales.
Art + Squat = X
Authors: Moore Alan W.
Published: July 2022

This paper was written for a talk of 2012 at the Universidad Complutense in Madrid. It is greatly indebted to the researches of the SqEK (Squatting Europe [or Everywhere] Kollectiv).The experiences and researches in New York City and Europe which form the basis of my analysis here are expanded in the 2015 book Occupation Culture, and glossed by firsthand texts by squatters in the anthology Making Room. I have revised this text some for this 2021 publication, but it is firmly rooted in its moment of optimism – the movement of the squares and Occupy Wall Street. Things have changed a lot since then in this most changeable of worlds.
Impacto del régimen neoliberal en la transformación social y reorganización espacial de la región Altos de Chiapas – México
Authors: Vázquez Manuel Roberto Parra , Carrasco Jorge Urdapilleta
Published: July 2022

Se analiza el impacto del neoliberalismo en la reestructuración de los territorios de la región Altos de Chiapas, México, de 1980 a 2020, a partir de describir cómo los organismos financieros internacionales posicionaron los principios neoliberales en el ámbito internacional, y cómo sus directrices fueron interiorizadas en las leyes y reglas de operación de los diferentes ámbitos de la acción gubernamental mexicana, estableciéndose un régimen que está generando profundas desigualdades entre las diversas regiones del país. Se toma el caso de la región Altos de Chiapas, por ser un laboratorio en el que se pueden encontrar un muestrario de los procesos que ocurren en la escala global y las acciones colectivas que rechazan las prácticas neoliberales. Para ello se refieren algunas organizaciones campesinas que operan en Comercio Justo, la organización de productores y Organizaciones de la Sociedad Civil para conformar mercados de cercanías, el establecimiento de plantaciones de frutales impulsadas desde el gobierno municipal, la lucha por la elección de gobiernos comunitarios conforme a los usos y costumbres, libres de partidos políticos.
Palabras Clave. Régimen neoliberal. Modos de vida. Estrategias campesinas. Sistemas socioambientales.
Representatividade feminina no contexto da coordenação de ações de extensão
Authors: Deus Lidiane Alves de , Oliveira Marco Antonio Moreira de , Braz Rodrigo Moreira , Deboçã Leonardo Pinheiro
Published: July 2022

The presence of women in the educational sphere and in the labor market, in addition to being a struggle with historical roots, has contemporary characteristics rooted in society, requiring knowledge and diagnosis of the most diverse forms of female performance, here dealing with the public environment. Therefore, the objective of this article was to carry out a temporal survey on the representation of women in the teaching position within the coordination of extension activities in a public university, with study object being the Viçosa Federal University, Rio Paranaíba Campus, State of Minas Gerais, Brazil. Data collection was carried out on websites that provide reports on servers and on the institution's internal system for recording outreach activities.  Among the surveys with greater evidence and theoretical proof, it could be diagnosed that women, although they do not represent the majority of university professors, are predominantly more present in the coordination of different types of extension activities (programs, projects, courses and events) than men, with emphasis on actions related to the Institute of Biological and Health Sciences, which have greater representation.
A migração para o ensino público: uma análise do direito à educação no Paraná em tempos de pandemia de Covid-19
Authors: Pilarski Mariel Mayer , Myszczuk Ana Paula , Pereira Victor Hugo , Carvalho Hilda Alberton de
Published: July 2022

O advento da pandemia de Covid-19 trouxe uma enorme crise social e econômica como consequência das medidas de controle de disseminação do vírus. No Brasil, o direito à educação previsto na Constituição foi significantemente afetado com a migração de alunos de escolas particulares para a rede pública de ensino. O objetivo deste estudo é analisar os dados do censo escolar para verificar esta migração. Para cumprir este objetivo, a pesquisa utiliza abordagem quantitativa e qualitativa, com dados obtidos do Consulta Matrículas do INEP no lapso temporal de 2017 a 2020 no estado do Paraná, como também de pesquisa bibliográfica e documental relacionada ao tema. Identificou-se que a obrigatoriedade da educação pública foi construída desde a Constituição de 1824 e aperfeiçoada na Carta Magna de 1988. Outrossim, foi identificado discreto aumento de matrículas na rede pública de ensino paranaense em 2020, quebrando uma sequência de quedas desde 2017. Sugere-se o aprofundamento do estudo para verificar a evasão escolar decorrente da pandemia de Covid-19.
Os Novos Ecossistemas do “Sertão Carioca”: Transformação da Paisagem e História de Uso da Terra na Bacia do Rio Piabas (1968-2018), Rio de Janeiro
Authors: Noronha Felipe , Freitas Marcelo Motta , Solórzano Alexandro
Published: July 2022

As transformações na paisagem são produto histórico das relações sociais com o ambiente. Os ecossistemas modificados por essas agências respondem a estas transformações com novidades ecológicas, sobretudo na estrutura e composição. Atualmente podemos entender estas paisagens culturais como sistemas socioecológicos compostos por novos ecossistemas. As áreas distantes do centro urbano do Rio de Janeiro, conhecidas como “Sertão Carioca”, foram destinadas à agricultura e vêm sendo atingidas pelo processo de expansão urbana. Os ecossistemas remanescentes guardam as marcas da história de uso do solo. A bacia do rio Piabas, parte integrante do “Sertão Carioca”, foi analisada com objetivo de compreender a transformação da paisagem e identificar as mudanças na cobertura vegetal e uso das terras ocorridas no período de 1968 a 2018. Foram usadas fotografias aéreas de 1968 e imagens de satélite de 2018 a fim de comparar os mapeamentos da cobertura vegetal e uso das terras na escala 1:10.000. A bacia do rio Piabas em 1968 apresentava predominância de plantios agrícolas (63%), onde viam-se lavouras perenes ou temporárias e plantios de banana. Nas serras, encontravam-se fragmentos florestais remanescentes (25%) e árvores frutíferas plantadas ao redor das casas (4,3%). No ano 2018, predominam novos ecossistemas florestais em estágio médio de regeneração (47%). O avanço dessa classe contou com o recuo dos bananais e com o decreto do Parque Estadual da Pedra Branca (PEPB). Das lavouras temporárias e permanentes, restam somente 10%. Comparando a variação das transformações nesses 50 anos, o crescimento da área urbana se destaca (539%), registrando a chegada da cidade ao “Sertão”. Essa expansão urbana ocorreu principalmente sobre ecossistemas de baixada. A falta de planejamento territorial que concilie a conservação da biodiversidade e atividades agroecológicas no processo de urbanização dessa região afetará as condições de qualidade de vida de seus residentes.
Procesos en la fabricación de paneles fotovoltaicos, revisión desde la perspectiva de generación de valor empresarial
Authors: Rojas Hernández Dairon , Espinosa Martínez Estela Gertrudis , Pelegrín Mesa Arístides , Menoya Zayas Sandys
Published: July 2022

El presente artículo consiste en una propuesta de un procedimiento para identificar las actividades y procesos que transforman y añaden valor, sobre la base de una entrada para obtener un resultado, y una salida que a su vez satisfaga los requerimientos del cliente, que contribuyan a una acertada toma de decisiones, así como, una correcta medición de la eficiencia y eficacia en la empresa de Componentes Electrónicos, Pinar del Río, Cuba. La investigación aborda la fundamentación teórica y práctica del desarrollo de los procesos, y sus distintas clasificaciones e importancia, para aplicarlo en la fabricación de paneles fotovoltaicos.
Propuesta de un manual de procedimientos contables en empresas tabacaleras
Authors: Cabera Padrón Nexys , Guerra González María de Jesús , Rojas Hernández Dairon , Herrera Pineda Anisley
Published: July 2022

La presente investigación está encaminada a implementar un Manual de Procedimientos Contables en la Empresa Integral y de Tabaco Consolación del Sur, Pinar del Río, Cuba. Los resultados de la investigación se centran en la fundamentación teórica de los elementos relacionados con los sistemas contables actuales, atendiendo a la situación contable vigente en las entidades tabacaleras, contribuyendo a mejorar la gestión del sistema contable y el proceso de toma de decisiones. Proporcionando información oportuna y confiable, permitiendo detectar debilidades importantes y tomar acciones correctivas necesarias por el equipo administrativo y operativo de la empresa; en aras de lograr un proceso contable actualizado y armonizado a las Normas Internacionales de Contabilidad.
A Effect of Radial Clearance, Corner Radius and Micro Lateralization on Contact Stress of Metallic and Ceramic Hip Prosthesis
Authors: Shankar S. , R. Nithyaprakash , K.A. Selvamani , K. Ponappa , Uddin Mohammad , Santhosh B.R.
Published: July 2022

Edge loading leads to high contact stress at the rim of the contact. This is due to less radial clearance and excessive lateral head displacement which potentially causes implant failure. The ceramic implants have a high possibility of fracture compared with metallic implants because of above-said reasons. The present study focuses on the investigation of contact stress for the combined effect of radial clearance (0.05-0.75 mm) and micro-lateralisation conditions (1-2.5 mm) for Metal-on-Metal (M-o-M) and Ceramic-on-Ceramic (C-o-C) pairs. The contact stresses are analysed for round corners of the acetabulum cup geometry for the above-said combinations with four different arc radii (1- 4mm). Finite element modeling (FEM) of femur head with half of the acetabulum cup is considered for the current study. Contact stress values obtained for 2 mm and 4 mm round corner geometry are quite low when compared with 1 and 3 mm round corners even for larger radial clearances and high lateral head displacements. The study also showed von Mises stress value obtained for M-o-M pair is quite low for 4 mm round corner for larger radial clearance and high lateral head displacements. Similarly, in C-o-C pair the compressive stress values are minimum for 4 mm round corner. Since the stress values were minimum for 4 mm round corner geometry, it clearly indicates that even edge loading occurs and the round corner geometry would be very helpful in reducing the stress for both M-o-M and C-o-C pairs.
Kinematic Analyses of Metallic Plate Perforation by Penetrators with Various Nose Geometries
Authors: Akyürek T.
Published: July 2022

This study analyses kinematics of a metallic plate perforation by a penetrator with truncated ogive nose geometry to find solutions also to blunt, conical, ogive, and hemi-spherical nosed penetrators. Plugging, ductile hole enlargement, dishing, and petal forming failure modes are used in the analyses. Acceleration throughout perforation is calculated by using the related failure mode, analytical model, and the target-penetrator interaction geometry. Depending on the failure model; back lip and front lip formation during ductile hole enlargement, plug formation during plugging, and deflection of target plate during dishing is also analysed. Analyses are based on projectile’s equation of motion, momentum and energy equations, and projectile-target plate interactions. The analyses results for selected cases, with the impact velocity range 215-863 m/s, are compared with the test data. The residual velocity estimation for a strike velocity is close to the related test data with an error of 0.3-2.2 %, except for conical nosed penetrators at impact velocities approaching the ballistic limit velocity
Evolutionary Trends in True Time Delay Line Technologies for Timed Array Radars
Authors: Sreenivasulu K. , RAY Dr. K. P. , VENGDARAJAN Dr.
Published: July 2022

Timed array technology is rapidly evolving in multiple areas such as high resolution imaging radar, automotive, medical, high data rate communication applications etc. Timed arrays by utilising True Time Delay (TTD) lines in place of phase shifters mitigate beam squint and pulse dispersion issues associated with wide instantaneous bandwidth arrays. This paper presents on review of evolutionary trends in TTD line architectures starting from coaxial cable to photonic integrated circuit. The paper also reports on critical parameters of TTD lines, their importance and implication in design of typical X-band imaging radar. Comparison of different TTD line architectures in terms of configuration, implementation, merits and demerits are discussed in detail for wideband array application. The paper also brings out the integration aspects of TTD lines as part of T/R modules and proposes suitable design schemes towards performance optimization and realisation of timed arrays.
An Experimental Investigation into Effect of Reinforcement Material on Mechanical Properties of Linear Low Density Polyethylene (LLDPE)
Authors: Tripathi Prashant , Nath Tameshwer
Published: July 2022

Through this paper an experimental investigation has been done. The composites of different reinforced material having significantly good strength and improved properties are prepared. A comparative study was performed among LLDPE with non-woven fabric, LLDPE and non-woven fabric reinforced with rice husk, LLDPE with non- woven fabric and ash of rice husk. Linear Low Density Polymer (LLDPE) is used as base material in this fabrication process. LLDPE is mixed with the non-woven fabric in different percentage composition by weight in addition to the other natural reinforcement material (rice husk). Further an experiment was performed to calculate the mechanical properties like tensile strength, Melt flow Index (MFI), flexural strength, hence a comparative study of composite with different types of reinforcement was done to investigate the effect of mixing of different reinforcement material. Results shows that LLDPE with non-woven fabric (15 %) have less strength as compared to LLDPE with non-woven fabric and rice husk (10 %) and LLDPE with non-woven fabric and ash of rice husk (5 %). Water absorption characteristics are studied following ASTMD 570, results shows that LLDPE absorbs 0.15 per cent water, followed by LLDPE with rice husk (0.03 %) and LLDPE with ash (0.038 %).
Histological and Clinical Stage Profiles of Young-aged Breast Carcinoma
Authors: Sugiarto Hadiyanto Alda Vania , Miranti Ika Pawitra , Prajoko Yan Wisnu , Istiadi Hermawan
Published: July 2022

Background: Breast cancer is the most common type of malignancy in women. Many studies report that the characteristics and prognosis of young-aged breast carcinoma are worse than in old age. Data on young-aged breast carcinoma in Indonesia is relatively lacking and always needs updates.Objective: To determine the incidence and distribution based on histological profiles and clinical stage, as well as the association between molecular subtype with grade and clinical stage of young-aged breast carcinoma (<40 years old) at Dr. Kariadi General Hospital Center in 2018-2020.Methods: This research was an observational descriptive study using medical records of young-aged breast carcinoma patients which were recorded at Dr. Kariadi General Hospital Center from 1st January 2018 until 31st December 2020. The data were processed with Microsoft Excel and SPSS.Results: The results showed that there were 110 patients consisting of 25 people in 2018, 37 people in 2019, and 48 people in 2020. The most common histological and clinical stage was IBC-NST with 75 people (68,18%), Luminal B with 53 people (48,18%). grade II with 71 people (64,65%), and stage IV with 45 people (40,09%). There is a significant association between molecular subtype and grade (p=0.003). There is no significant association between molecular subtype and clinical stage (p=0.704).Conclusion: The incidence of young-aged breast carcinoma at Dr. Kariadi General Hospital Center in 2018-2020 was increasing every year. The most common histological profiles and clinical stage during that period were IBC-NST, Luminal B, grade II, and stage IV. There is a significant association between molecular subtype and grade.Keywords: Breast carcinoma, clinical stage, grade, histological type, molecular subtype, young age
Association of Type of Antiepileptic Drugs and Serum Vitamin D Levels among People with Epilepsy
Authors: Maharani Adelia Putri , Syariva Hasna , Ngestiningsih Dwi , Wati Arinta Puspita , Jaeri Santoso
Published: July 2022

Background: Epilepsy is a brain disease characterized by repeated unprovoked seizures at least two times with an interval of more than 24 hours between the first seizure and subsequent seizures. Valproic acid is an anti-seizure drug. Long-term use of valproic acid may be associated with metabolic disorders such as weight gain, and lipid profile changes, including vitamin D levels. Objectives: To determine the association of type of antiepileptic drugs and serum vitamin D levels among people with epilepsy.Methods: A cross-sectional study among 24 people with epilepsy was obtained from the outpatient clinic Diponegoro National Hospital Semarang. The subjects were then classified based on the type of antiepileptic drugs into two groups. The first group was subjects who used valproic acid (n=15) and the second group was subjects who used phenytoin (n=9). The demographic and clinical data were collected, then the measurement of vitamin D levels was performed using ELISA. The two independent samples T-test were performed to determine the differences of serum vitamin D levels among people with epilepsy.Results: The mean of serum vitamin D levels among 24 subjects were 17,32 + 6,37 ng/mL, and the mean of serum vitamin D levels based on the type of antiepileptic drugs were 16,92 + 4.27 ng/mL for the first group and 18 + 9.16 ng/mL for the second group. Furthermore that there was no significant difference in the serum vitamin D levels in both groups (p=0,697).Conclusion: There is no different effect of valproic acid and phenytoin on the serum vitamin D levels among people with epilepsy.
Wound Healing Response to Full-Thickness Skin Defect Sprague Dawley Rats Given Ozonated Black Cumin Oil Viewing from The Profile of Neutrophil and Macrophage Count
Authors: Syahputra Igor Rizkia
Published: July 2022

The incidence of wounds keeps increasing and inadequate treatment can cause the wound to become infected. Ozone has antibacterial properties and can help activate pro-inflammatory agents in the wound healing process; one of the methods is oil ozonation, for example with black cumin oil. Topical administration of black cumin plays a role in wound healing because of its antibacterial and antifungal properties, and plays a role in increasing the epitalization process. To determine the effectiveness of applying ozonated black cumin oil (Nigella sativa) on the healing process of full-thickness skin defects in Sprague Dawley rats, in terms of the number of macrophage and neutrophil cells. This research was an experimental study with a post-test only control group design method. Total sample of 48 Sprague Dawley rats was divided into 6 groups. The first group was given gentamicin ointment, the second group was given 0.9% normal saline, the third to the fifth group was given ozone black with doses of ozone respectively, namely 1400 mg/ml, 1800 mg/ml and 2200 mg/ml. Incision for taking the tissue samples was held on the 3rd and 7th day according to the treatment group. The tissue samples were subjected to histopathological examination with HE staining. A significant decrease in neutrophil levels occurred at the dose of 1,400mg/ml ozonated black cumin oil on day 7 (p=<0.001), dose of 1,800 mg/ml on day 3 (p=0.021) and day 7 (p=<0.001), doses of 2,200mg/ml at day 3 (p=0.020) and day 7 (p=<0.001) compared with a positive control group (given gentamicin). A significant decrease in macrophage levels occurred at a dose of 1,400mg/ml on day 3 (p=0.037) and 7 (p=0.019), a dose of 1,800 mg/ml on day 3 (p <0.001) and 7 (p=0.020), dose 2,200mg/ml on day 3 (p=<0.001) and day 7 (p=0.020).
CORELLATION OF STRESS LEVEL DURING COVID-19 PANDEMIC AND THE INSIDENCE OF ACNE ON STUDENTS: STUDY ON UNDERGRADUATE STUDENTS OF THE FACULTY OF MEDICINE OF DIPONEGORO UNIVERSITY
Authors: Saktini Fanti
Published: July 2022

Background: Acne vulgaris (Acne) is the most common inflammatory disease of skin among adolescents and young adults (85%). Corona Virus Disease (COVID-19) pandemic had enforced lockdowns and thus inevitably converted the conventional schooling system to online learning. These changes raised psychological burden among students, including medical students. Psychological distress might influence the emergence of acne or added its severity.Aim: To know the correlation between stress level during pandemic and the incidence of acne vulgaris among students in Faculty of Medicine Diponegoro University.Method: This study used cross-sectional design, incorporating 97 undergraduate students (batch of 2018-2020) of Faculty of Medicine Diponegoro University, whom suffered from acne, had consented to participate consecutively. Data consisted of subjects’ characteristic and Depression and Anxiety Stress Scale 21 questionnaire. These data were analysed using Chi-square test.Results: Most of the subjects suffered from acne (60.8%), whereas the level of stress varied from normal (61.9%), mild (25.8%), moderate (9,3%), to severe (3.1%). There was no significant relationship between stress level during COVID-19 pandemic and the incidence of acne vulgaris among subjects. (p=0,805).Conclusion: There was no significant relationship between stress level during COVID-19 pandemic and the incidence of acne vulgaris among medical students.
The Relationship Between Obstructive Sleep Apnea And Levels Of Depression And Anxiety In Young Adults
Authors: Yunika Kanti
Published: July 2022

ABSTRACTBackground: Obstructive sleep apnea (OSA) is one of the most common and serious sleep disorders that can cause various neurocognitive disorders such as depression and anxiety. OSA can occur in young adults, whom are in an important developmental age in human life. The relationship between OSA and levels of depression and anxiety has never been studied in young adults, especially college students. Early identification and treatment is expected to have an impact on better quality of life and productivity..Aim: To determine the relationship of OSA with levels of depression and anxiety in young adultsMethods: An observational study with a cross sectional design. Data were obtained from Berlin questionnaire, Zung Self-Rating Depression Scale and Zung Self-Rating Anxiety Scale which were filled out in September-November 2021. Bivariate analysis of OSA's relationship with depression and OSA with anxiety was tested using chi-square test. Multivariate logistic regression analysis was performed to test for confounding variables.Results:  There was a significant relationship between OSA and depression (p=0,000, OR 4.07) and OSA and anxiety (p=0,000, OR 4.5) in young adults. Logistic regression analysis showed that gender was a confounding variable of anxiety (p=0.044) in young adults.Conclusion: There is a significant relationship between OSA and levels of depression and anxiety in young adults. Young adults who have OSA are 4.07 times more likely to be depressed than young adults who don’t have OSA. Young adults who have OSA are 4.5 times more likely to experience anxiety than young adults who don’t have OSA. There is a significant relationship between OSA and the level of anxiety controlled by the confounding variable, namely gender.
Česká verze dotazníku CLASS určeného k měření profesionality postoje k biologii
Authors: Janštová Vanda , Dvořáková Radka Marta , Mourek Jan , Rajsiglová Ina , Novotný Petr
Published: August 2022

Jako příspěvek k výzkumným možnostem kvantifikovat posun v postoji žáků a studentů k přírodovědnému oboru, konkrétně biologii, představujeme český překlad dotazníku CLASS-Bio (Colorado Learning Attitudes about Science Survey). Ten vedle analýzy postojů zahrnuje také vyjádření míry profesionality postojů k oboru na škále od začátečníka po odborníka, chápané jako procentuální shoda odpovědí respondenta s odborníky na danou disciplínu. Původní anglickou verzi jsme po překladu, adaptaci na české prostředí a jeho diskuzi v plénu autorů rozšířeném o rodilou mluvčí pilotně ověřili na souboru 198 respondentů. Upravili jsme dílčí formulační nejasnosti a finální verze byla použita pro sběr dat od dalších 184 respondentů. Dotazník vyplňovali v obou případech online uchazeči o bakalářské studium biologie na Přírodovědecké fakultě Univerzity Karlovy. Míra shody s experty byla stejná u mužů a žen v obou sběrech (cca 78 %). Mezi dosaženým skóre respondentů z pilotního sběru ve znalostním testu z biologie a mírou shody s odborníky byla signifikantní, i když slabá, pozitivní korelace. Konfirmační faktorovou analýzou jsme potvrdili strukturu faktorů v dotazníkui v českém překladu a prostředí. Výsledkem je tak ověřený překlad etablovaného nástroje, jehož užití umožňuje mezinárodně srovnatelné analýzy.
Integrating 3D cameras into sterile surgical environments: A comparison of different protective materials regarding scan accuracy
Authors: Wagner Lars , Bernhard Lukas , Fuchtmann Jonas , Asim Karaoglu Mert , Ladikos Alexander , Feußner Hubertus , Wilhelm Dirk
Published: July 2022

This work presents a sterile concept for 3D cameras within sterile surgical environments. In the digital operating room (OR), such cameras can serve as a valuable data source for cognitive workflow assistance systems, e.g decision or mechatronic support systems. One recent example are robotic assistants for instrument handling, such as the robotic scrub nurse currently developed in the framework of the SASHA-OR research project1. In this context, we detect laparoscopic instruments and the surgical environment with a 3D camera, whereby hygienic requirements need to be met. Using a Zivid Two sensor, we generated point clouds of the laparoscopic instruments located in an instrument holder and a drop zone. We compared the effect of using different pane types and thicknesses for the sterile camera enclosure and compared the performance with and without protective pane in terms of the point cloud accuracy. When analyzing multiple pane types, polymethyl methacrylate with 0.5 mm thickness (PMMA 0.5) provided the best results. At a scan distance of 560 mm to the surface center, which is required for the complete acquisition of a laparoscopic instrument, PMMA 0.5 achieved the smallest Chamfer distance (CD) values for both the scans with the laparoscopic instruments in the instrument holder (0.23 ± 1.52 mm) and in the drop zone (0.12 ± 0.25 mm).
On finite 𝜎-tower groups
Authors: Cai Jinzhuan , Wang Zhigang , Safonova Inna N. , Skiba Alexander N.
Published: August 2022

In this paper, 𝐺 is a finite group and 𝜎 a partition of the set of all primes ℙ, that is,

σ
=

{

σ
i

∣

i
∈
I

}

\sigma=\{\sigma_{i}\mid i\in I\}

, where

P
=

⋃

i
∈
I

σ
i

\mathbb{P}=\bigcup_{i\in I}\sigma_{i}

and

σ
i

∩

σ
j

=
∅

\sigma_{i}\cap\sigma_{j}=\emptyset

for all

i
≠
j

i\neq j

.
If 𝑛 is an integer, we write

σ
⁢

(
n
)

=

{

σ
i

∣

σ
i

∩

π
⁢

(
n
)

≠
∅

}

\sigma(n)=\{\sigma_{i}\mid\sigma_{i}\cap\pi(n)\neq\emptyset\}

and

σ
⁢

(
G
)

=

σ
⁢

(

|
G
|

)

\sigma(G)=\sigma(\lvert G\rvert)

.
A group 𝐺 is said to be 𝜎-primary if 𝐺 is a

σ
i

\sigma_{i}

-group for some

i
=

i
⁢

(
G
)

i=i(G)

and 𝜎-soluble if every chief factor of 𝐺 is 𝜎-primary.
We say that 𝐺 is a 𝜎-tower group if either

G
=
1

G=1

or 𝐺 has a normal series

1
=

G
0

<

G
1

<
⋯
<

G

t
-
1

<

G
t

=
G

1=G_{0}<G_{1}<\cdots<G_{t-1}<G_{t}=G

such that

G
i

/

G

i
-
1

G_{i}/G_{i-1}

is a

σ
i

\sigma_{i}

-group,

σ
i

∈

σ
⁢

(
G
)

\sigma_{i}\in\sigma(G)

, and

G
/

G
i

G/G_{i}

and

G

i
-
1

G_{i-1}

are

σ
i
′

\sigma_{i}^{\prime}

-groups for all

i
=

1
,
…
,
t

i=1,\ldots,t

.
A subgroup 𝐴 of 𝐺 is said to be 𝜎-subnormal in 𝐺 if there is a subgroup chain

A
=

A
0

≤

A
1

≤
⋯
≤

A
t

=
G

A=A_{0}\leq A_{1}\leq\cdots\leq A_{t}=G

such that either

A

i
-
1

⁢
⊴
⁢

A
i

A_{i-1}\trianglelefteq A_{i}

or

A
i

/

(

A

i
-
1

)

A
i

A_{i}/(A_{i-1})_{A_{i}}

is 𝜎-primary for all

i
=

1
,
…
,
t

i=1,\ldots,t

.
In this paper, answering to Question 4.8 in [A. N. Skiba, On 𝜎-subnormal and 𝜎-permutable subgroups of finite groups, J. Algebra
436 (2015), 1–16], we prove that a 𝜎-soluble group

G
≠
1

G\neq 1

with

|

σ
⁢

(
G
)

|

=
n

\lvert\sigma(G)\rvert=n

is a 𝜎-tower group if each of its

(

n
+
1

)

(n+1)

-maximal subgroups is 𝜎-subnormal in 𝐺.
Early cultivation of broomcorn millet in southern Britain: evidence from the Late Bronze Age settlement site of Old Catton, Norfolk
Authors: Brudenell Matthew , Fosberry Rachel , Phillips Tom , Kwiatkowska Malgorzata
Published: August 2022

A single pit containing a mixed assemblage of charred plant remains, including broomcorn millet, was discovered during excavation of a Middle–Late Bronze Age settlement at Old Catton, Norfolk. Radiocarbon dating of this assemblage dates it to the Late Bronze Age—including a date of 910–800 cal BC for the millet itself—making this the earliest securely dated use of broomcorn millet in Britain.
The Effects of Acute Social Media Exposure on Body Dissatisfaction and Eating Behavior of Male and Female Students
Authors: Pink Aimee E. , Lim Phoebe X. H. , Sim Aaron Y. , Cheon Bobby K.
Published: August 2022

Introduction: Experimental research has examined the effect of social media on body dissatisfaction, but little attention has been given to the impact on eating behavior. Across two studies, we tested the causal relationship between acute social media use, body dissatisfaction and eating behavior. Methods: In Study 1, 80 female participants (age: M = 20.75 years; BMI: M = 21.3) viewed their own Facebook account or a news website before completing a portion size selection task. In Study 2 (pre-registered), 148 participants (81 females; age: M = 20.92 years; BMI: M = 22.19), viewed their own or an experimenter-curated Instagram profile before consuming potato chips ad-libitum. Results: In Study 1, body dissatisfaction was significantly higher in participants who viewed Facebook (compared to a news website) and significantly mediated the effect of condition on portion size selection. In Study 2, regardless of condition females reported significantly smaller ideal body sizes and higher body dissatisfaction compared to males. When females reported a thinner body size as ideal, females in the personal Instagram consumed significantly less potato chips than those in the control Instagram condition. When males reported a smaller actual body size, males in the personal Instagram condition consumed significantly less potato chips than males in the control Instagram condition. Discussion: Findings suggest brief bouts of social media use may produce immediate disruptions to body image of both sexes, and restrained snack intake of females endorsing thin ideals.
Comparison of the Phenomenology of Hallucination and Delusion Characteristics in People Diagnosed With Borderline Personality Disorder and Schizophrenia
Authors: Merrett Zalie , Castle David J. , Thomas Neil , Toh Wei Lin , Beatson Josephine , Broadbear Jillian , Rao Sathya , Rossell Susan L.
Published: August 2022

Hallucinations and delusions in borderline personality disorder (BPD) are understudied. The authors explore the phenomenology of multisensory hallucinations and delusions in individuals with BPD and compare them to those in individuals with schizophrenia spectrum disorders (SSD). Clinical psychopathology was also explored. Eighty-nine adults participated and were categorized into four groups: BPD with voices, BPD without voices, SSD with high BPD traits, and SSD with low BPD traits. Among individuals with BPD, 81% reported visual and tactile hallucinations, 75% reported olfactory hallucinations, and 94% experienced delusions. When comparing BPD with and without voices, there were no significant differences in nonpsychotic psychopathology. Slight differences were found when hallucinations in BPD were compared with hallucinations in SSD, but overall the experiences were similar across diagnoses. The BPD group also reported significantly higher rates of paranoia/suspiciousness and delusions of guilt than the SSD group. Multisensory hallucinations and delusions occur in BPD and should be explored when treating people with BPD.
Blocking Effects in Social Inference Generalize Across Targets: Learning to Interpret a Person's Behavioral Cues Interferes With Learning About Other People's Behavior
Authors: Vaz André , Mata André , Palma Tomás A.
Published: August 2022

Recent research has explored cue competition phenomena in social learning. In particular, blocking effects have been observed in the way people learn to infer someone's internal states from their behavioral cues: When people learn to associate a certain behavior with a certain internal state, this blocks their learning of subsequent behavioral cues that also predict the same state, when those cues are presented with the original behavior. In this research, we show that this blocking effect generalizes across targets, such that learning that a behavior predicts an internal state in a person hinders learning that other cues predict the same internal state in a different person, when both behaviors are presented simultaneously. This effect proved robust, and it was not moderated by the group membership of the targets.
Improving intercultural pragmatic competencies in online L2 Spanish classrooms through task-supported learning
Authors:   Heartland Community College (Normal, IL), USA, Bachelor Jeremy W.
Published: August 2022

Learners of a second language often have limited access to the native culture of that language in an authentic way, resulting in them committing linguistic and intercultural mistakes. One of the main advantages of task-based learning is that it can expose students to real-world circumstances, which makes learning a language more meaningful and inclusive of appropriate language behaviour. Task-based learning has become an accepted method for learning a language in face-to-face classroom environments, but its applicability to online learning is largely unaddressed. The author proposed well-organised online role-plays based on a task-based approach involving native speakers, which helped students interact in an authentic way and demonstrate their understanding of culture. The author conducted the research to increase intercultural pragmatic competencies in online L2 classrooms regarding common pragmatic speech acts as to not only increase their pragmatic competency but to also motivate students. The students from the online experimental group who were exposed to task-supported role-plays performed better than the online control group of students; however, student motivation was only mildly impacted. Thus, pragmatics and interculturality can be effectively taught in online L2 classrooms through task-supported learning, though motivation may require longer interventions.