bluuebunny/crossref_metadata_2025 huggingface dataset:
Think of the Conus Medullaris at the Time of Diagnosis of Fetal Sacral Agenesis
Authors: Mottet Nicolas , Martinovic Jelena , Baeza Claire , Guimiot Fabien , Bault Jean-Philippe , Aubry Marie Cécile , Riethmuller Didier , Zerah Michel , Cretolle Celia , Benachi Alexandra
Published: October 2016

Background: There is no precise prenatal indicator to refine an accurate prognosis in case of sacral agenesis and to define the diagnostic approach and outcome criteria in case of fetal sacral agenesis using 3 characteristics of the conus medullaris (CM): its position, its appearance, and associated spinal abnormalities. Methods: Ten cases of prenatally diagnosed sacral agenesis were included between 1995 and 2014 after collating ultrasound findings and prenatal computed tomography data. Results: Two cases of total sacral agenesis and 8 of partial agenesis were included. There were 1 or more spinal abnormalities in 8/10 cases: 6 lipomas, 4 low-lying tethered cords, 2 diastematomyelias, and 1 syringomyelia. Three situations were distinguished: sacral agenesis with low-lying tethered cord, sacral agenesis with a truncated CM, and sacral agenesis with CM in place. If the sacral agenesis is isolated, a lipoma should be sought. Lipomas of the filum have a good prognosis, whereas lipomas of the CM cause neurological deficits in 1/3 of cases. When there is a low-lying tethered cord, a diastematomyelia or a syringomyelia may be associated. In truncated CM, there may be a severe form suggestive of caudal regression syndrome. Serious ultrasound signs are immobility of the lower limbs, talipes equinovarus, impaired bladder emptying, and dilatation of the upper urinary tract. Conclusion: A precise description of the morphology of the CM, its position, and associated spinal malformations are important in defining the neurological, urinary, gastrointestinal, and motor functions prognosis in cases of fetal sacral agenesis.
Diffuse Infiltrative Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis Completely Cured by Transcatheter Arterial Chemoembolization: Case Report with 8-Year Follow-Up
Authors: Kim Suk Bae
Published: October 2016

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and its treatment options are determined by shape, liver function, loci, and stages of cancer. Diffuse type of infiltrative HCC accompanied by portal vein tumor thrombosis (PVTT) has the poorest prognosis among other HCCs and there are no other prominent treatment options than systemic chemotherapy. In this study, we report a case of a 56-year-old man with diffuse infiltrative HCC accompanied by PVTT who achieved complete remission for 8 years after receiving conventional transcatheter arterial chemoembolization using adriamycin and gelfoam.
Intestinal Bacterial Infection Diagnosed by Histological Examination of Endoscopic Biopsy Specimens
Authors: Yuki Michiko , Emoto Yuko , Yoshizawa Katsuhiko , Yuri Takashi , Tsubura Airo
Published: October 2016

Intestinal spirochetosis (IS) in humans is characterized by spirochetal microorganisms attached to the luminal surface of the colonic epithelium. In the present case, attached organisms appeared as 3- to 4 μm-thick (average thickness, 3.4 μm) basophilic fringes or haze in HE-stained endoscopic biopsy specimens. The basophilic fringes were clearly labeled by Treponema pallidum antiserum. Because IS is relatively rare in developed countries, thin basophilic fringes characteristic of IS are readily overlooked. Thus, the recognition of histological characteristics of this disease is important for its diagnosis.
Intra-Arterial Mechanical Thrombectomy: An Effective Treatment for Ischemic Stroke Caused by Endocarditis
Authors: Sveinsson Olafur , Herrman Lars , Holmin Staffan
Published: October 2016

Patients with stroke secondary to infectious endocarditis have a high in-hospital morbidity and mortality, with only one-third becoming functionally independent. Infective endocarditis is usually considered a relative contraindication to thrombolytic therapy. We describe 3 consecutive cases of acute middle cerebral artery occlusion due to infective endocarditis, who were all successfully treated with intra-arterial mechanical thrombectomy using the Solitaire device. From this limited experience, mechanical thrombectomy could be used as an effective acute treatment for ischemic stroke in patients with infective endocarditis. Mechanical thrombectomy is most likely a more effective and safer treatment than intravenous thrombolysis in this patient group.
Clinical Factors of Disease Reclassification or Progression in a Contemporary Cohort of Prostate Cancer Patients Elected to Active Surveillance
Authors: Porcaro Antonio Benito , Cavicchioli Francesca , Mattevi Daniele , De Luyk Nicolò , Corsi Paolo , Sebben Marco , Tafuri Alessandro , Processali Tania , Cerasuolo Mattia , Tamanini Irene , Cacciamani Giovanni , Cerruto Maria A. , Brunelli Matteo , Novella Giovanni , Siracusano Salvatore , Artibani Walter
Published: October 2016

Objectives: To evaluate clinical predictors of disease reclassification or progression (DR/P) in prostate cancer patients elected to active surveillance (AS). Material and Methods: Patients were assessed on the basis of DR/P criteria. Predictors of DR/P were evaluated by multivariate logistic regression and Cox proportional hazards. Results: The median DR/P free time was 16.5 months. DR/P was detected in 30 out of 84 cases (35.7%). In DR/P cases, the median prostate volume (PV) was significantly lower (34.7 vs. 42.7 ml) and the percentage of cases with 2 or 3 vs. 1 initial biopsy positive cores (BPC) was significantly higher (36.7 vs. 7.4%). The multivariate logistic regression model showed that PV (OR 0.9; p = 0.021) and initial n >1 BPC (OR 9.8; p = 0.001) were independent predictors of DR/P. By Cox multivariate proportional hazards, only n >1 BPC predicted early DR/P (hazard ratio 3.1; p = 0.003). Conclusions: In a contemporary cohort of patients elected to AS, independent factors stratifying the risk of DR/P were PV and initial BPC, which also predicted early DR/P. In patients elected to AS, the identification of risk factors of DR/P require early re-biopsy. Confirmatory studies are required.
Cristãs-novas no Brasil Colônia: um olhar sobre o Marranismo
Authors: Schetini Júnior Ademir
Published: October 2016

Na Península Ibérica, a historiografia sobre a Inquisição ganhou impulso nos idos de 1990 e as pesquisas resultaram na produção de uma vasta literatura a respeito da atuação do Tribunal do Santo Ofício da Inquisição. Em Portugal, as investigações foram facilitadas com a ampliação do acesso aos arquivos abrigados no Arquivo Nacional da Torre do Tombo, no qual podem ser contabilizados mais de quarenta mil processos, além de variados núcleos documentais. A pesquisa ganhou maior complexidade com as recentes investigações relativas à presença feminina na documentação inquisitorial e, em particular, de mulheres acusadas de preservação de práticas judaicas. A teia das relações abrangidas pela territorialidade colonial – distando sujeitos, fortalecendo hierarquias e suscitando formas distintas de atuação – delimita o pano de fundo sobre o qual se assenta o presente trabalho, sobre o papel das mulheres associadas ao criptojudaísmo em três grupos de cristãos-novos, nas capitanias do Rio de Janeiro (GORENSTEIN, 2005), da Bahia (ASSIS, 2012) e de Pernambuco (VEIGA, 2013).
E os Pomos eram de Ouro: A importância da Citricultura de Nova Iguaçu para a economia fluminense e brasileira nas décadas de 1920 à de 1940
Authors: Souza Ricardo Luiz
Published: October 2016

O presente trabalho possui como objetivos principais, esmiuçar a evolução da Citricultura no país e o seu grande desenvolvimento no município fluminense de Nova Iguaçu, no período compreendido entre as décadas de 1920 e 1940 do século XX. Não obstante, será também analisado nesse trabalho, como a laranja desenvolveu-se como uma alternativa de diversificação econômica, com o intuito de suprimir a grande dependência das exportações do café e como tal produto irá encontrar as condições para se desenvolver em Nova Iguaçu. Assim, discutiremos os incentivos, deliberações e políticas estatais para a laranja ser comercializada com a devida qualidade e pujança, com a adoção dos Packing Houses, entre outras medidas,  além é claro,  como o boom da produção e  exportação de laranjas trará recursos financeiros para o Estado Brasileiro e Fluminense.
Eugenia negativa em Ponta Grossa? Uma análise das representações sobre a eugenia no discurso de José martins Pinto
Authors: Holowate Isaias
Published: October 2016

A eugenia surgiu no final do século XIX como a ciência do aprimoramento da espécie humana. Seus defensores acreditavam que, através da seleção dos indivíduos considerados como eugenicamente superiores e da restrição à reprodução dos indivíduos não-eugênicos, seria possível promover um melhoramento da espécie. Os discursos eugenistas foram apropriados por pensadores de diversas regiões do mundo, sendo ressignificados para atender às necessidades das culturas locais. Em Ponta Grossa, no Paraná, os pressupostos eugenistas foram defendidos por um grupo de pensadores proveniente da burguesia urbana, que colaboravam com o periódico Diário dos Campos, havendo uma multiplicidade de representações sobre a eugenia defendidos na publicação. A pesquisa busca analisar a representação sobre a eugenia produzida pelo colaborador do jornal José Martins Pinto, que apresentava diversas aproximações com princípios defendidos pela eugenia negativa. A partir das investigações, busca-se refletir sobre as características da representação produzida por esse personagem em relação ao discurso de outros colaboradores do periódico, e embasados na teoria das representações do historiador Roger Chartier, compreender as ressignificações produzidas por esse indivíduo e as aproximações com os discursos produzidos sobre o tema no meio nacional e internacional.
O Amazonas de Luto: o rito fúnebre e a consagração de Eduardo Gonçalves Ribeiro
Authors: Matos Geisimara Soares
Published: October 2016

O artigo que aqui apresentamos faz parte de minha monografia de conclusão de curso. Nela, procuramos identificar como se deu a construção da memória histórica de Eduardo Gonçalves Ribeiro (1862-1900) e sua longevidade na memória histórica amazonense. A escolha desse personagem se deu devido a importância dada à sua figura no estado do Amazonas, o discurso ufanista e laudatório construído sobre ele e o silenciamento de sua negritude. A parte que aqui iremos apresentar trata da morte, velório e enterro de Eduardo Ribeiro como momentos emblemáticos para sua consolidação e consagração como herói do Amazonas, ou seja, sujeito que trouxe a modernidade para esse povo. Para isso, utilizamos basicamente de fontes jornalísticas da época a fim de entender como se deu o ritual, e mais do que isso, também entender que discursos a grande imprensa fez e apresentou a respeito deste morto e sua morte. Ao fim e ao cabo, nos deparamos com um ritual fúnebre que teve como objetivo importante a consagração de Ribeiro, fazendo isso através do enaltecimento de seus feitos, e de sua popularidade.
"O próspero caminho do interior - Economia e escravos em Sorocaba, Itu e Campinas - 1770-1830"
Authors: Bastos Nêilor Felipe
Published: October 2016

Este artigo pretende compreender os fatores que levaram à mudança do perfil econômico da capitania/província de São Paulo a partir de meados do século XVIII, entender o surgimento das vilas de Itu, Campinas e Sorocaba e a mudança de seus aspectos demográfico e econômico no contexto das alterações pelas quais passa São Paulo no período em questão e, por fim, enxergar estas mudanças com foco na evolução da população escrava das citadas vilas, com base na análise das listas nominativas (documentos censitários) de Itu de 1773, 1801 e 1830, comparando os resultados com as análises de alguns estudiosos sobre Campinas e Sorocaba. Após a contagem da população total e do número de escravos, foram feitos quadros para se comparar a quantidade de escravos em relação à população, bem como gráficos para análise do total de proprietários de escravos produtores e não produtores de açúcar. Para se atingir os objetivos mencionados, recorreu-se principalmente aos trabalhos de Carlos de Almeida Prado Bacellar, Eni de Samara Mesquita, Maria Luiza Marcílio e Paulo Eduardo Teixeira, dentre outros.
Reactivating the Neural Dimension Role in Interactive Arts
Authors: Ahmedien Diaa Ahmed Mohamed
Published: October 2016

The author created a neural interactive artwork in the form of a holographic puzzle in an attempt to expand the functional role of the neural brain activities in the interactive artistic processes. With synchronous neural communication being the structural concept for this project, the experimental setup connects the display system of puzzle pieces with the participant’s electrical brain activities via an EEG system. This experiment reveals the effect of the functional expansion of the participant’s neural responses and the possibility of analyzing the interactive processes quantitatively in an operational interpretation of the neural dimension in interactive arts.
Annie and the Shaman: Exploring Data via Provocative Artifacts
Authors: Kilker Julian
Published: October 2016

Designed as a “provocative artifact,” the multimedia piece Annie and the Shaman raises questions about how information is collected, archived and employed. The work connects two contexts with notable data histories: Nevada’s aboveground atomic testing and its Basin and Range region. To highlight an empirical engagement with location, audio and visual data from the famous 1953 Annie test was visually integrated into a relevant context on location, rather than composing visuals post hoc. The project proposes onsite data visualizations as a method to encourage researcher and public engagement, especially when original data and process information is included with the exhibit.
Inside Out: Video Mapping and the Architectural Facade
Authors: Neuman Eran
Published: October 2016

This article discusses the conceptual implications of the introduction of video mapping to building facades, the role of the facade as an architectural mediator between interior and exterior spaces and the ways in which video mapping transforms this role. At one time transparent (in modern architecture) and then opaque (in postmodern architecture), the architectural facade has traditionally maintained its integrity as a mediator between public and private spheres. Video mapping proposes to transform this situation by creating an everchanging image for the facade, as well as by exploiting the facade’s ability to absorb any projection on its surface. The outcome is a video-mapped facade, composed of both a physical surface and the video’s virtual images; together, these two elements create a new type of architectural facade.
Advanced Constructivism and Postgravity Art: Theoretical and Philosophical Implications
Authors: Puncer Mojca
Published: October 2016

This article discusses art’s potential in outer space through a dialogue between European and Russian avant-garde traditions, and the postgravity art project by Dragan Živadinov, Dunja Zupančič and Miha Turšič. They enact a 50-year theater performance, Noordung:: 1995–2045, with the help of high tech, Suprematism and Constructivism. The performance is based on five replays every 10 years with the same actors and on technological substitutes of the deceased. The project has several topical theoretical implications. The author explores its key philosophical aspects and presents new potentialities for a systemic cognitive model for image and space conceptual transformations within the context of contemporary art and aesthetics.
Art Today and Philosophical Aesthetics
Authors: Di Summa-Knoop Laura T.
Published: October 2016

The demise of grand narratives of art, and the emergence of “post-historical art,” have produced a chasm between the tradition of philosophical aesthetics and the production and reception of contemporary art, a divide that has deprived philosophy of the fundamental role it had played, arguably, until the end of the Modern period. The goal of this paper, which focuses primarily on art after 2000, is to investigate possible venues and directions in the current production and reception of art that might lead to a reconciliation of these two poles and to the advancement of new philosophical strategies for the analysis of art. Specifically, I will concentrate on three aspects of the experience of art today: first, the emphasis, in the production and reception of artworks, on enactive accounts of artistic experience; secondly, the importance given to the ethical content of artworks and to their ability to trigger ethical, social, and political reflection; and, lastly, the growing role of the art market and its structures in the overall appreciation of the arts.
Jazz, Kant and Zen
Authors: Day Jonathan
Published: October 2016

Transgression and experimentation are at the heart of the musical composition with which this work begins. The compositional approaches employed developed from a consideration of Kant’s Critique of Judgement (1790) which offers a compelling explanation for the apparently bizarre “claim to objectivity” commonly made in judgements of taste. Kant’s final conclusion around the source of the claim is, for me, disappointing. This current work re-examines and extends his argument through an elision with Zen writing, and offers an alternate account. It is posited that the “claim to objectivity” operates as a linguistic marker, acknowledging the presence of experience that is trans-rational and supra-linguistic, and indicating a point/place at which language ceases to be viable. It relies on and incites an implicit shared understanding that aesthetic experience often exceeds language, and further indicates that one or more of the myriad unspeakable things are accessible nearby. This understanding is explored in relation to compositional practice, finding a powerful synergy with the writing of composers, improvisers, and avant-garde/jazz theorists. The work concludes with the suggestion that aesthetic experience and the “beautiful” may therefore signpost the ineffable, referring back to the score with which this work began.
Becoming Equivalent
Authors: Zhong Yong
Published: October 2016

This paper examines the introduction of “discourse” into China by looking into the different usages and interpretations of the word: what discourse currently is (话语 – a new coinage); what it used to be (语篇 – a largely superseded rendition, an assimilation); what it could be (other forms of transliteration, assimilation and Japanese-based renditions); and what it arguably should be (说力 – a new coinage). The paper discusses accordingly how Western critical concepts travel into China, how different modes of translation alter their meanings, and what translation strategy should best be employed to facilitate conceptual exchanges between the West and China. Additionally, the paper traces back a well-hidden Japanese “gene” in a majority of Chinese cultural concepts, discloses the conceptual flaws in Chinese renditions, and recommends an informed strategy for translating Western critical cultural concepts into Chinese.
Miki Kiyoshi and Interpretation
Authors: Morisato Takeshi
Published: October 2016

Japanese philosopher Miki Kiyoshi 三木清 (1897–1945) wrote an important text on translation entitled “Disregarded Translations” (keibetsu-sareta honyaku 軽蔑された翻訳). Among all Kyoto School thinkers, Miki was probably the most prolific writer. His interests spanned various intellectual topics such as philosophy, literature, religion, politics, and journalism. This paper offers a brief introduction to Miki’s conception of translation as well as, for the first time, an English translation of his text. “Disregarded Translations” deals with Japanese scholars’ propensity to revere Western philosophical texts in their original forms, while ignoring the outstanding wealth of insight that their translations can provide in their own language.
Four new species of Chaetogastra (Melastomeae, Melastomataceae) from Southern Brazil
Authors: MEYER FABRÍCIO SCHMITZ , GOLDENBERG RENATO
Published: October 2016

Four new species of Chaetogastra are described: C. cordeiroi, C. crassifolia, C. cristaensis and C. riograndensis, recognized during a taxonomic study of the genus in Brazil. All of them come from southern Brazil, in the Atlantic Forest biome, at the states of Rio Grande do Sul, Santa Catarina and Paraná. All four species are threatened, under different categories.
Rhododendron longipedicellatum (Ericaceae), a new species from Southeastern Yunnan, China
Authors: CAI LEI , NEILSEN JENS , DAO ZHI-LING , MA YONG-PENG
Published: October 2016

A new species of Rhododendron (Ericaceae) in sect. Vireya subsect. Pseudovireya from Malipo County, Southeast Yunnan, China, R. longipedicellatum, is described and illustrated. The new species is most similar to R. rushforthii but differs in its arrangement of leaves, the shape and color of the lamina, length of the petiole and the size of the calyx lobes. It also resembles R. trancongii and R. Datiandingense, but differs in its color and shape of the lamina, the leaf apex, lengths of the petiole, pedicel and stamens, and the indumentum of the ovary.
Description of a new species of Lethe (Lepidoptera, Nymphalidae, Satyrinae) from western Yunnan, China
Authors: LANG SONG-YUN , DUAN SHAO-ZHONG
Published: October 2016

A new species, Lethe tengchongensis Lang sp. nov., from Tengchong County, Mts. Gaoligong, western Yunnan Province, SW China is described and illustrated.
A review of the Callogobius (Teleostei: Gobiidae) from the Red Sea with the description of a new species
Authors: DELVENTHAL NAOMI R. , MOOI RANDALL D. , BOGORODSKY SERGEY V. , MAL AHMAD O.
Published: October 2016

Five species of Callogobius Bleeker have been previously reported from the Red Sea: C. amikami Goren, Miroz & Baranes, C. clarki (Goren), C. dori Goren, C. flavobrunneus (Smith), and C. maculipinnis (Fowler). Records of C. bifasciatus (Smith) in the Red Sea are referable to C. clarki. Callogobius amikami has been previously known only from a single specimen, the holotype from the Red Sea, and two photographs, a live juvenile from Oman and a live specimen at an aquarium at Coral World, Eilat. We obtained a possible additional juvenile from the Red Sea, although we are unable to definitively determine its identity. Red Sea specimens previously identified as C. maculipinnis [or C. irrasus (Smith)] represent a new species, distinguished from the latter by normally having four sets of transverse mandibular rows on each side (rather than three); this species is described here as Callogobius pilosimentum sp. nov. Four specimens of an additional, undescribed species of Callogobius, C. sp. A, have been collected from the Red Sea, but we withhold a formal description because this species is currently under study by colleagues. Callogobius sclateri (Steindachner), previously known from the Indo-West Pacific, is reported from the Red Sea for the first time. A key to all seven species is provided. Each species is photographed, habitat is described and a brief description with detailed comparisons is provided. The new species and C. clarki are endemic to the Red Sea.
On the generic placement and taxonomic status of some Miltochrista taxa described by Franz Daniel (Lepidoptera, Erebidae, Arctiinae)
Authors: VOLYNKIN ANTON V.
Published: October 2016

Three Miltochrista Hübner, [1819] taxa described by Daniel, Miltochrista tibeta Daniel, 1951, M. tibeta clara Daniel, 1951 and M. gilva Daniel, 1951 are transferred to the genus Lyclene Moore, [1860]. M. tibeta clara is upgraded to the species level. Adults, male and female genitalia are illustrated.
Soil Apparent Thermal Diffusivity Estimated by Conduction and by Conduction–Convection Heat Transfer Models
Authors: Tong Bing , Gao Zhiqiu , Horton Robert , Wang Linlin
Published: October 2016

Soil heat transfer is complex, and conduction-alone models may not always perform well in estimating soil apparent thermal diffusivity. Soil apparent thermal diffusivity is related to soil temperature change propagation rates. Soil temperature data collected at the Tazhong station in China were used to examine the characteristics of soil apparent thermal diffusivity determined by three different algorithms and the sum of vertical gradient of soil apparent thermal diffusivity and apparent water flux density . The results showed that 1) soil apparent thermal diffusivity obtained with a conduction–convection algorithm had a better agreement with soil apparent thermal diffusivity obtained with a phase algorithm than with soil apparent thermal diffusivity obtained with an amplitude algorithm except for the case of = 0; 2) when > 0, , and when < 0, ; 3) for a given soil temperature phase shift, increased (decreased) with increasing logarithmic amplitude attenuation when the phase shift was larger (smaller) than the logarithmic amplitude attenuation, reached a maximum value when the phase shift equaled the logarithmic amplitude attenuation, and increased with increasing logarithmic amplitude attenuation; and 4) for a given logarithmic amplitude attenuation, decreased with increasing phase shift and increased (decreased) with increasing phase shift when the phase shift was larger (smaller) than times the logarithmic amplitude attenuation. These mathematical conclusions were also confirmed with field data.
What a blind student taught me to see
Authors: Caswell Caroline
Published: October 2016

When a teacher educator is called on to teach a blind student in her class for aspiring teachers of elementary mathematics, she feels ill-prepared for the challenge. As she learns how to accommodate the student’s needs, she learns a lot about being a good teacher -- to not assume that a student will be able to show his or her learning the same way that other students do, to not underestimate what the student can do, and to trust that the student will do the work.
The Editor’s Note
Authors: Richardson Joan
Published: October 2016

Keeping an exemplary teacher’s knowledge isolated inside a classroom isn’t just poor practice, it’s almost malpractice. If you want to be an agent for change in your school or your district, work now to ensure that no teacher works in such isolation. Be an advocate for sharing what you know. Ask to observe another teacher teach because of what you will learn. Invite others to observe you and offer you feedback on how you can improve. Write articles and make presentations about what you’re learning from your work. By opening the doors to their practice, teachers demonstrate the value they place on their own learning and their belief that they have much to share with others.
The case for end-user involvement in design of health technologies
Authors: Walker Léonie , Clendon Jill
Published: October 2016

This paper reports a subset of data from a mixed methods project interviewing community nurses and nurse leaders/managers to explore the views, expectations, practice and attitudes of registered nurses working in the community concerning electronic health records and the use of mobile devices. Nurses displayed excellent understanding of privacy and consent concerning electronic patient records and health information technology (e-health). With targeted, individualised education, nurses use e-health and telehealth effectively. However, significant barriers were found regarding duplication of paper and electronic patient notes and multiple logins for different platforms and systems, resulting in forgotten and shared passwords. There was also evidence of some avoidance of essential systems; lack of infrastructure in some settings; inadequate systems for the use of digital cameras (e.g. tracking wound healing); and inability to access patient notes across settings to ensure integrated care. In conclusion, nurses are the largest group of health practitioners in New Zealand and are at the front line of patient care. Nurses need systems designed around their work methods and a good understanding of e-health in order to be able to use it effectively. Greater consultation with nurses is required to ensure the potential of e-health and its use is maximised.
Substitution rates of video consultations for traditional consultations at a tertiary public hospital
Authors: Caffery Liam J , Taylor Monica , Lucas Karen , Smith Anthony C
Published: October 2016

Using a case study approach, we conducted a retrospective review of 12 months of outpatient activity at the Princess Alexandra Hospital (PAH) in Brisbane, Australia. From our dataset we calculated two variables – the telehealth-eligible substitution rate and the overall telehealth substitution rate. Telehealth eligibility is specialty-specific and is based on clinical and geographical constraints. During the study period there were video consultations ( N = 1088) and traditional consultations ( N = 41,951). The telehealth-eligible and overall substitution rates were 17.5% and 2.5%, respectively. The overall telehealth substitution rate is substantially lower than the telehealth-eligible substitution rate. This is due to the majority of patients being from local catchment areas which are currently ineligible for video consultations at the PAH. The highest observed overall telehealth substitution rate was for the radiosurgery which had telehealth activity as a reportable key performance indicator since inception of the service, which may have contributed to the relatively high rate. In-home video consultations with patients who reside in metropolitan areas are needed to substantially increase the rate of telehealth substitution.
Assessment of solar access in urban environment: The case of the renewal of a city block in Espinho, Portugal
Authors: Marques Bruno , Corvacho Helena , Brandão Alves Fernando
Published: October 2016

The research project carried out aimed to establish guidelines for urban design, especially adjusted to specific climatic conditions and to local design practice. With the aid of a simulation program, Townscope III, several urban scenarios were characterized in what concerns solar access. Some results are presented for the specific case of a block in Espinho. Four different building models were tested. Solar access was evaluated and its repercussion on heating and cooling energy needs of the buildings was estimated. A virtual scenario with an increase of the density of the urban surrounding area was also assessed.
How I treat cryoglobulinemia
Authors: Muchtar Eli , Magen Hila , Gertz Morie A.
Published: October 2016

Cryoglobulinemia is a distinct entity characterized by the presence of cryoglobulins in the serum. Cryoglobulins differ in their composition, which has an impact on the clinical presentation and the underlying disease that triggers cryoglobulin formation. Cryoglobulinemia is categorized into two main subgroups: type I, which is seen exclusively in clonal hematologic diseases, and type II/III, which is called mixed cryoglobulinemia and is seen in hepatitis C virus infection and systemic diseases such as B-cell lineage hematologic malignancies and connective tissue disorders. Clinical presentation is broad and varies between types but includes arthralgia, purpura, skin ulcers, glomerulonephritis, and peripheral neuropathy. Life-threatening manifestations can develop in a small proportion of patients. A full evaluation for the underlying cause is required, because each type requires a different kind of treatment, which should be tailored on the basis of disease severity, underlying disease, and prior therapies. Relapses can be frequent and can result in significant morbidity and cumulative organ impairment. We explore the spectrum of this heterogeneous disease by discussing the disease characteristics of 5 different patients.
Editorial: Targeting JAM-C on mantle cell lymphoma B cells: time for clinical testing?
Authors: Pistoia Vito , Ferretti Elisa
Published: October 2016

Discussion on a novel pre-clinical therapeutic strategy based upon mAb-mediated targeting of the JAM-C adhesion molecule on MCL B cells
Free to Choose? Reform, Choice, and Consideration Sets in the English National Health Service
Authors: Gaynor Martin , Propper Carol , Seiler Stephan
Published: October 2016

Choice in public services is controversial. We exploit a reform in the English National Health Service to assess the effect of removing constraints on patient choice. We estimate a demand model that explicitly captures the removal of the choice constraints imposed on patients. We find that, post-removal, patients became more responsive to clinical quality. This led to a modest reduction in mortality and a substantial increase in patient welfare. The elasticity of demand faced by hospitals increased substantially post-reform and we find evidence that hospitals responded to the enhanced incentives by improving quality. This suggests greater choice can raise quality. (JEL D12, I11, I18)
Intertemporal Price Discrimination: Dynamic Arrivals and Changing Values
Authors: Garrett Daniel F.
Published: October 2016

We study the profit-maximizing price path of a monopolist selling a durable good to buyers who arrive over time and whose values for the good evolve stochastically. The setting is completely stationary with an infinite horizon. Contrary to the case with constant values, optimal prices fluctuate with time. We argue that consumers’ randomly changing values offer an explanation for temporary price reductions that are often observed in practice. (JEL D82)
Persuading Voters
Authors: Alonso Ricardo , CÂmara Odilon
Published: October 2016

In a symmetric information voting model, an individual (politician) can influence voters' choices by strategically designing a policy experiment (public signal). We characterize the politician's optimal experiment. With a nonunanimous voting rule, she exploits voters' heterogeneity by designing an experiment with realizations targeting different winning coalitions. Consequently, under a simple-majority rule, a majority of voters might be strictly worse off due to the politician's influence. We characterize voters' preferences over electoral rules and provide conditions for a majority of voters to prefer a supermajority (or unanimity) voting rule, in order to induce the politician to supply a more informative experiment. (JEL D72, D83)
Dynamic Procurement under Uncertainty: Optimal Design and Implications for Incomplete Contracts
Authors: Arve Malin , Martimort David
Published: October 2016

We characterize the optimal dynamic contract for a long-term basic service when an uncertain add-on is required later on. Introducing firm risk aversion has two impacts. Profits for the basic service can be backloaded to induce cheaper information revelation for this service: an Income Effect which reduces output distortions. The firm must also bear some risk to induce information revelation for the add-on. This Risk Effect reduces the level of the add-on but hardens information revelation for the basic service. The interaction between these effects has important implications for the dynamics of distortions, contract renegotiation, and the value of incomplete contracts. (JEL D47, D81, D86)
Case Report: X-linked recessive anhidrotic ectodermal dysplasia with immunodeficiency and an unusual Aspergillus infection
Authors: Shokuhfar Tahaamin , Mo’mmen Zahra , Panah Elnaz , Alborzei Abdollvahhab , Torabi Sagvand Babak , Aghamohamadi Asghar
Published: October 2016

NEMO (NF-kB essential modulator) is a regulatory factor involved in signaling pathways of the innate and adaptative immune systems. Hypomorphic mutation of the NEMO gene (also called IKBKG gene) on the X chromosome leads to X-linked recessive anhidrotic ectodermal dysplasia with immunodeficiency. Affected male children present a developmental phenotype with hypotrichosis, hypohydrosis, and hypodontia with conical incisors and susceptibility to pyogenic bacteria, mycobacteria and viruses. Most also have impaired antibody response to polysaccharide antigens. Here we present the case of a 7-year-old boy with disseminated BCGitis and unusual Aspergillus infection who was later diagnosed with a homozygous mutation of the NEMO gene. Appropriate long term anti-mycobacterial medications, prophylactic anti-fungal therapy and current monthly intravenous immunoglobulin (IVIG) stabilized the patient’s condition and has significantly improved his general health. High incidence of atypical mycobacterial infection in such cases emphasize the need for prophylaxis.

In conclusion, attention to gender, pattern of infections, and precise physical exam helped us to diagnose and appropriately manage this case. We propose prophylactic therapy for mycobacterial and opportunistic infections after the confirmation of homozygous NEMO gene mutation.
The concept of professional dialogue of employees of law enforcement bodies
Authors: Мальцева  , Maltseva Tatyana
Published: October 2016

The article reveals the problem of the effectiveness of law enforcement, which is largely determined by productivity solutions communicative tasks. Specificity of work of police officers is associated with the ability to properly organize contact, dialogue and debate, to establish mutual understanding and fruitful relationships, resolve conflicts, to find mutually acceptable options for cooperation. The professional dialogue police officer faced with different people. Very rarely is a situation in which there are no communication barriers. Therefore, law enforcement specifics of building interpersonal relationships determine the special conditions of work, extraordinary circumstances and dissimilar cases and situations, especially this communication (not by choice, and often not by choice) with new and unusual people, things and actions are not always cause empathy and sympathy.
Legal US base in the area of inclusive education: a critical analysis
Authors: Максименко  , Maksimenko Mariya
Published: October 2016

Nowadays in all developed countries people with special needs have the same rights as everyone else and the law protects them from discrimination. Unfortunately, some problems still exist. This article examines success of the full inclusion system in American education. We also analyze problems that the system has and give recommendations.
Mushroom Biomass: Some Clinical Implications of β-Glucans and Enzymes
Authors: Barros Ana , Bell Vitoria , Ferrão Jorge , Calabrese Vittorio , Fernandes Tito
Published: October 2016

Mushrooms have attracted market attention because they are a potential source of bioactive compounds able to perform several functions in organisms with benefits for the health of the consumer. Cultivation processes vary according a) industrial fermentation - in large vats to produce extracted form of mushrooms or b) closed cultivation system - individually grown in jars on an aseptic “substrate” with controlled lighting and irrigation to produce a biomass form of mushrooms. Biomass is the mycelium with primordia (young fruiting body - before the mushroom blooms) containing all the nutrients and active compounds, including β-glucans, enzymes and secondary metabolites. The classification of mushroom biomass varies according to the presentation; the biomass can be classified as a “food” if in powder form or, classified as a “dietary supplement” in tablet form. While tablet mushroom biomass is considered a dietary supplement, mushroom extracts are designated pharmaceutical compounds, pharmanutrients or nutraceuticals. Here we illustrate the difference between mushrooms in the biomass and extract forms, the similarities and differences on its content on enzymes, secondary metabolites and on β-glucans, as a soluble and fermentable fibre. Of particular note is the rich enzyme activity in the biomass form of mushrooms. Such activity includes enzymes that prevent oxidative stress (superoxide dismutase), enzymes that prevent cellular growth (protease, glucoamylase) and enzymes that promote detoxification (cytochrome P-450, peroxidase, glucose-2-oxidase). β-glucans have been proposed to act as “biological response modifiers” based on their effects on the immune system, and its role in the prevention and treatment of various metabolic syndrome-linked diseases. This review focuses also on some described health-promoting potential of mushroom biomass, all through immunomodulation. The role of intestinal microbiota is enhanced.
Effect of in Vitro Gastrointestinal Digestion on Bioactivity of Poultry Protein Hydrolysate
Authors: Anna Torkova , Alexey Kononikhin , Anna Bugrova , Vyacheslav Khotchenkov , Mikhail Tsentalovich , Ulia Medvedeva
Published: October 2016

In vitro simulated gastrointestinal digestion (GID) was performed to evaluate changes in bioactive properties of Poultry protein hydrolysate HCP Premium P150 (PPH) showing strong antioxidant (448.2±37.0 µM TE/g of protein) and moderate Angiotensin-I converting enzyme inhibitory activity (IC50 0.617±0.022 mg/ml). Antioxidant and ACE-inhibitory activity were measured with use of ORAC assay and FRET-substrate methods, correspondingly. Gastric digestion (GD) increased ACE inhibitory activity 2.23 times and didn’t change antioxidant activity of PPH significantly. The subsequent intestinal digestion increased antioxidant activity 1.29 times and didn’t change ACE-inhibitory activity significantly. New potent ACE-inhibitory peptides: APGAPGPVG (IC50 16.2±3.8 µM), PDLVF (IC50 84.9±6.3 µM) and antioxidant dipeptide WG (2.29±0.04 µM TE/µM) were identified in the digested PPH. The digested PPH proved to be a rich source of antioxidant and ACE inhibiting molecules and could be a potential new food ingredient used for prevention or treatment of socially significant diseases.
Production of Traditional Cheese Coagulant in Farmhouse and Coagulating Effect
Authors: Say Dilek , Guzeler Nuray
Published: October 2016

Milk-clotting enzymes are the primary active agents in the manufacture cheeses. Animal rennet, microbial coagulant and plant coagulant are used as milk coagulants in cheese making. However, alternative milk coagulants are investigated instead of animal enzymes due to slaughtering of young ruminant. Manufacturing of milk clotting enzyme in farmhouse have been employed successfully for many centuries in Mediterrenean region and Toros mountain villages of Turkey for the production of traditional Tulum cheese. Figs, raisins, white beans, chickpeas, carob, granulated sugar, salt, yoghurt and home-made rennet (sarkanak) are found in the content of this enzyme. This mixture is left at room temperature for 5-6 days. The enzyme is filtered from using cloth bag and added into milk for coagulation. In this research; chemical composition of cow’s milk, goat’s milk and ewe’s milk were determined and obtained enzymes from different manufacturers were investigated of clotting effects on cow’s milk, goat’s milk and ewe’s milk. Four different coagulants had a strong coagulating effect on raw and pasteurized ewe's milk. The highest milk clotting activity of all coagulant samples were seen in ewe's milk, followed by cow's milk and goat's milk.
Bioavailability of Quercetin
Authors: Kaşıkcı Müzeyyen , Bağdatlıoğlu Neriman
Published: October 2016

Quercetin is generally present as quercetin glycoside in nature and involves quercetin aglycone conjugated to sugar moieties such as glucose or rutinose. Quercetin has been reported to exhibit antioxidative, anti-carcinogenic, anti-inflammatory, anti-aggregatory and vasodilating effects. Unfortunately, quercetin bioavailability is generally poor and several factors affect its bioavailability. Quercetin bioavailability varies widely between individuals. Gender may affect quercetin bioavailability, but there is no clear evidence. There has been little research looking for the effects of age and vitamin C status on bioavailability of quercetin supplements, but there is no research seeking out the effects of age and vitamin C status on bioavailability of food-derived quercetin. Presence of sugar moieties increases bioavailability and differences in quercetin-conjugated glycosides affect bioavailability. For instance, onion-derived quercetin, which is mainly quercetin glucoside, is more bioavailable than apple-derived quercetin, which contains quercetin rhamnoside and quercetin galactoside. Quercetin is lipophilic compound, thus dietary fat enhances its bioavailability. Nondigestible fiber may also improve quercetin bioavailability. Quercetin bioavailability is greater when it is consumed as an integral food component. This study reviews and discusses factors affecting quercetin bioavailability.
Effect of Green Banana Peel Flour Substitution on Physical Characteristics of Gluten-Free Cakes
Authors: Türker Burcu , Savlak Nazlı , Kaşıkcı Müzeyyen
Published: October 2016

Celiac Disease is the most common food-sensitive entoropathy in humans that is triggered by the consumption of wheat gluten as well as related with protein in barley, rye and oat. The only treatment ever known for celiac disease is gluten-free diet. Most gluten-free food product on the market is rich in starch but poor in terms of other nutrients, functional and health benefitial ingredients. Green (unripe) banana is a good source of resistant starch, non-starch polysaccharides including dietary fiber, antioxidants, poliphenols, essential minerals such as potassium, various vitamins e.g. provitamin A, carotenoid, B1, B2, C which are important for human health. In this research, it is aimed to develop nutritious and functional gluten free cake formulations by substituting green banana peel flour (GBPF) with rice flour (5%, 10%, 15% and 20%) and to investigate physical properties of GBPF substituted cakes. Cake volume, specific volume, density, baking loss and height of the cakes were in the range of 831.44 – 1034.11 cm3, 1.91-2.41 cm3/g, 0.41-0.52 g/cm3, 16.38-18.14% and 4.36-5.77 cm respectively. As a result, GBPF substituted gluten free cakes were successfully produced. Physical analyses of gluten free cakes showed that 5% and 10% GBPF substitution did not affect gluten free cake volume, specific volume, density and baking loss negatively. 5% and 10% GBPF substituted cakes were not different from control cake statistically (p>0.05). However, substitution levels of 15% and 20% resulted in poorer physical properties. Sensory analysis (data not shown) indicated that all GBPF substitution levels were acceptable, as determined by hedonic scala tests. By developing a nutritious gluten free cake alternative, it is expected to provide an alternative in the dietary diversity of individuals with celiac disease.