bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin
Authors: Harada Naoki , Okuyama Mai , Teraoka Yoshiaki , Arahori Yumi , Shinmori Yoh , Horiuchi Hiroko , Luis Paula B. , Joseph Akil I. , Kitakaze Tomoya , Matsumura Shigenobu , Hira Tohru , Yamamoto Norio , Iuni Takashi , Goshima Naoki , Schneider Claus , Inui Hiroshi , Yamaji Ryoichi
Published: January 2022

The identification of molecular targets of bioactive food components is important to understand the mechanistic aspect of their physiological functions. Here, we have developed a screening system that enables us to determine the activation of G protein-coupled receptors (GPCRs) by food components and have identified GPR55 as a target for curcumin. Curcumin activated GPR55 and induced serum-response element- and serum-response factor-mediated transcription, which were inhibited by Rho kinase and GPR55 antagonists. Both the methoxy group and the heptadienone moiety of curcumin were required for GPR55 activation. The F1905.47residue of GPR55 was important for the interaction with curcumin. The curcumin-induced secretion of glucagon-like peptide-1 in GLUTag cells was inhibited by a GPR55 antagonist. These results indicate that expression screening is a useful system to identify GPCRs as targets of food components and strongly suggest that curcumin activates GPR55 as an agonist, which is involved in the physiological function of curcumin.
Hemolysis contributes to anemia during long-duration space flight
Authors: Trudel Guy , Shahin Nibras , Ramsay Timothy , Laneuville Odette , Louati Hakim
Published: January 2022

Anemia in astronauts has been noted since the first space missions, but the mechanisms contributing to anemia in space flight have remained unclear. Here, we show that space flight is associated with persistently increased levels of products of hemoglobin degradation, carbon monoxide in alveolar air and iron in serum, in 14 astronauts throughout their 6-month missions onboard the International Space Station. One year after landing, erythrocytic effects persisted, including increased levels of hemolysis, reticulocytosis and hemoglobin. These findings suggest that the destruction of red blood cells, termed hemolysis, is a primary effect of microgravity in space flight and support the hypothesis that the anemia associated with space flight is a hemolytic condition that should be considered in the screening and monitoring of both astronauts and space tourists.
Drivers of variation in occurrence, abundance, and behaviour of sharks on coral reefs
Authors: Lester E. , Langlois T. , Lindgren I. , Birt M. , Bond T. , McLean D. , Vaughan B. , Holmes T. H. , Meekan M.
Published: January 2022

Quantifying the drivers of population size in reef sharks is critical for the development of appropriate conservation strategies. In north-west Australia, shark populations inhabit coral reefs that border growing centres of human population, industry, and tourism. However, we lack baseline data on reef sharks at large spatial scales (hundreds of km) that might enable managers to assess the status of shark populations in the face of future development in this region. Here, we examined the occurrence, abundance and behaviour of apex (Galeocerdo cuvier, Carcharhinus plumbeus) and reef (C. amblyrhynchos, C. melanopterus, Triaenodon obesus) sharks using > 1200 deployments of baited remote underwater stereo-video systems (stereo-BRUVs) across > 500 km of coastline. We found evidence for species-specific influences of habitat and fishing activities on the occurrence (probability of observation), abundance (MaxN) and behaviour of sharks (time of arrival to the stereo-BRUVs and likelihood of feeding). Although the presence of management zoning (No-take areas) made little difference to most species, C. amblyrhynchos were more common further from boat ramps (a proxy of recreational fishing pressure). Time of arrival for all species was also influenced by distance to boat ramp, although patterns varied among species. Our results demonstrate the capacity for behavioural metrics to complement existing measures of occurrence and abundance in assessing the potential impact of human activities on shark populations.
Machine learning prediction model of acute kidney injury after percutaneous coronary intervention
Authors: Kuno Toshiki , Mikami Takahisa , Sahashi Yuki , Numasawa Yohei , Suzuki Masahiro , Noma Shigetaka , Fukuda Keiichi , Kohsaka Shun
Published: January 2022

Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. We evaluated 19,222 consecutive patients undergoing PCI between 2008 and 2019 in a Japanese multicenter registry. AKI was defined as an absolute or a relative increase in serum creatinine of 0.3 mg/dL or 50%. The data were split into training (N = 16,644; 2008–2017) and testing datasets (N = 2578; 2017–2019). The area under the curve (AUC) was calculated using the light gradient boosting model (GBM) with selected variables by Lasso and SHapley Additive exPlanations (SHAP) methods among 12 traditional variables, excluding the use of an intra-aortic balloon pump, since its use was considered operator-dependent. The incidence of AKI was 9.4% in the cohort. Lasso and SHAP methods demonstrated that seven variables (age, eGFR, preprocedural hemoglobin, ST-elevation myocardial infarction, non-ST-elevation myocardial infarction/unstable angina, heart failure symptoms, and cardiogenic shock) were pertinent. AUC calculated by the light GBM with seven variables had a performance similar to that of the conventional logistic regression prediction model that included 12 variables (light GBM, AUC [training/testing datasets]: 0.779/0.772; logistic regression, AUC [training/testing datasets]: 0.797/0.755). The AKI risk model after PCI using ML enabled adequate risk quantification with fewer variables. ML techniques may aid in enhancing the international use of validated risk models.
Surveillance of antimicrobial-resistant Escherichia coli in Sheltered dogs in the Kanto Region of Japan
Authors: Hata Akihisa , Fujitani Noboru , Ono Fumiko , Yoshikawa Yasuhiro
Published: January 2022

There is a lack of an established antimicrobial resistance (AMR) surveillance system in animal welfare centers. Therefore, the AMR prevalence in shelter dogs is rarely known. Herein, we conducted a survey in animal shelters in Chiba and Kanagawa prefectures, in the Kanto Region, Japan, to ascertain the AMR status of Escherichia coli  (E. coli) prevalent in shelter dogs. E. coli was detected in the fecal samples of all 61 and 77 shelter dogs tested in Chiba and Kanagawa, respectively. The AMR was tested against 20 antibiotics. E. coli isolates derived from 16.4% and 26.0% of samples from Chiba and Kanagawa exhibited resistance to at least one antibiotic, respectively. E. coli in samples from Chiba and Kanagawa prefectures were commonly resistant to ampicillin, piperacillin, streptomycin, kanamycin, tetracycline, and nalidixic acid; that from the Kanagawa Prefecture to cefazolin, cefotaxime, aztreonam, ciprofloxacin, and levofloxacin and that from Chiba Prefecture to chloramphenicol and imipenem. Multidrug-resistant bacteria were detected in 18 dogs from both regions; β-lactamase genes (blaTEM, blaDHA-1, blaCTX-M-9 group CTX-M-14), quinolone-resistance protein genes (qnrB and qnrS), and mutations in quinolone-resistance-determining regions (gyrA and parC) were detected. These results could partially represent the AMR data in shelter dogs in the Kanto Region of Japan.
Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment
Authors: Meijs Daniek A. M. , van Bussel Bas C. T. , Stessel Björn , Mehagnoul-Schipper Jannet , Hana Anisa , Scheeren Clarissa I. E. , Peters Sanne A. E. , van Mook Walther N. K. A. , van der Horst Iwan C. C. , Marx Gernot , Mesotten Dieter , Ghossein-Doha Chahinda ,   CoDaP investigators, Heijnen Nanon F. L. , Bickenbach Johannes , van der Woude Meta C. E. , Raafs Anne , van Kuijk Sander M. J. , Smits Luc J. M. , Janssen Emma B. N. J. , Pierlet Noёlla , Goethuys Ben , Bruggen Jonas , Vermeiren Gilles , Vervloessem Hendrik , Mulder Mark M. G. , Koelmann Marcel , Bels Julia L. M. , Bormans-Russell Laura , Florack Micheline C. D. M. , Boer Willem , Vander Laenen Margot
Published: January 2022

Although male Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients have higher Intensive Care Unit (ICU) admission rates and a worse disease course, a comprehensive analysis of female and male ICU survival and underlying factors such as comorbidities, risk factors, and/or anti-infection/inflammatory therapy administration is currently lacking. Therefore, we investigated the association between sex and ICU survival, adjusting for these and other variables. In this multicenter observational cohort study, all patients with SARS-CoV-2 pneumonia admitted to seven ICUs in one region across Belgium, The Netherlands, and Germany, and requiring vital organ support during the first pandemic wave were included. With a random intercept for a center, mixed-effects logistic regression was used to investigate the association between sex and ICU survival. Models were adjusted for age, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, comorbidities, and anti-infection/inflammatory therapy. Interaction terms were added to investigate effect modifications by sex with country and sex with obesity. A total of 551 patients (29% were females) were included. Mean age was 65.4 ± 11.2 years. Females were more often obese and smoked less frequently than males (p-value 0.001 and 0.042, respectively). APACHE II scores of females and males were comparable. Overall, ICU mortality was 12% lower in females than males (27% vs 39% respectively, p-value < 0.01) with an odds ratio (OR) of 0.62 (95%CI 0.39–0.96, p-value 0.032) after adjustment for age and APACHE II score, 0.63 (95%CI 0.40–0.99, p-value 0.044) after additional adjustment for comorbidities, and 0.63 (95%CI 0.39–0.99, p-value 0.047) after adjustment for anti-infection/inflammatory therapy. No effect modifications by sex with country and sex with obesity were found (p-values for interaction > 0.23 and 0.84, respectively). ICU survival in female SARS-CoV-2 patients was higher than in male patients, independent of age, disease severity, smoking, obesity, comorbidities, anti-infection/inflammatory therapy, and country. Sex-specific biological mechanisms may play a role, emphasizing the need to address diversity, such as more sex-specific prediction, prognostic, and therapeutic approach strategies.
KIAA0319 influences cilia length, cell migration and mechanical cell–substrate interaction
Authors: Diaz Rebeca , Kronenberg Nils M. , Martinelli Angela , Liehm Philipp , Riches Andrew C. , Gather Malte C. , Paracchini Silvia
Published: January 2022

Following its association with dyslexia in multiple genetic studies, the KIAA0319 gene has been extensively investigated in different animal models but its function in neurodevelopment remains poorly understood. We developed the first human cellular knockout model for KIAA0319 in RPE1 retinal pigment epithelia cells via CRISPR-Cas9n to investigate its role in processes suggested but not confirmed in previous studies, including cilia formation and cell migration. We observed in the KIAA0319 knockout increased cilia length and accelerated cell migration. Using Elastic Resonator Interference Stress Microscopy (ERISM), we detected an increase in cellular force for the knockout cells that was restored by a rescue experiment. Combining ERISM and immunostaining we show that RPE1 cells exert highly dynamic, piconewton vertical pushing forces through actin-rich protrusions that are surrounded by vinculin-rich pulling sites. This protein arrangement and force pattern has previously been associated to podosomes in other cells. KIAA0319 depletion reduces the fraction of cells forming these actin-rich protrusions. Our results suggest an involvement of KIAA0319 in cilia biology and cell–substrate force regulation.
RETRACTED ARTICLE: Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes
Authors: Asseri Saad Mohamed , Elsherbiny Nehal M. , El-Sherbiny Mohamed , Sherif Iman O. , Alsamman Alsamman M. , Maysarah Nadia M. , Elsherbini Amira M.
Published: January 2022

The burden of diabetes mellitus (DM) and associated complications is increasing worldwide, affecting many organ functionalities including submandibular glands (SMG). The present study aims to investigate the potential ameliorative effect of glycyrrhizic acid (GA) on diabetes-induced SMG damage. Experimental evaluation of GA treatment was conducted on a rat model of type I diabetes. Animals were assigned to three groups; control, diabetic and GA treated diabetic groups. After 8 weeks, the SMG was processed for assessment of oxidative stress markers, autophagy related proteins; LC3, Beclin-1 and P62, vascular regulator ET-1, aquaporins (AQPs 1.4 and 5), SIRT1 protein expressions in addition to LC3 and AQP5 mRNA expressions. Also, parenchymal structures of the SMG were examined. GA alleviated the diabetes-induced SMG damage via restoring the SMG levels of oxidative stress markers and ET-1 almost near to the normal levels most probably via regulation of SIRT1, AQPs and accordingly LC-3, P62 and Beclin-1levels. GA could be a promising candidate for the treatment of diabetes-induced SMG damage via regulating oxidative stress, autophagy and angiogenesis.
Gas discrimination by simultaneous sound velocity and attenuation measurements using uncoated capacitive micromachined ultrasonic transducers
Authors: Iglesias Hernandez Luis , Shanmugam Priyadarshini , Michaud Jean-François , Alquier Daniel , Certon Dominique , Dufour Isabelle
Published: January 2022

Chemically functionalized or coated sensors are by far the most employed solution in gas sensing. However, their poor long term stability represents a concern in applications dealing with hazardous gases. Uncoated sensors are durable but their selectivity is poor or non-existent. In this study, multi-parametric discrimination is used as an alternative to selectivity for uncoated capacitive micromachined ultrasonic transducers (CMUTs). This paper shows how measuring simultaneously the attenuation coefficient and the time of flight under different nitrogen mixtures allows to identify hydrogen, carbon dioxide and methane from each other and determine their concentration along with identification of temperature and humidity drifts. Theoretical comparison and specific signal processing to deal with the issue of multiple reflections are also presented. Some potential applications are monitoring of refueling stations, vehicles and nuclear waste storage facilities.
Comparison of growth performance among channel-blue hybrid catfish, ccGH transgenic channel catfish, and channel catfish in a tank culture system
Authors: Abass Nermeen Y. , Ye Zhi , Alsaqufi Ahmed , Dunham Rex A.
Published: January 2022

Fish is an essential source of high-quality protein for people worldwide. The present study was designed to compare the growth performance among the channel-blue hybrid catfish, channel catfish transgenic for the channel catfish growth hormone (ccGH) cDNA driven by the antifreeze protein promoter from an ocean pout Zoarces americanus (opAFP-ccGH), and non-transgenic channel catfish control. Mean body weight of channel-blue hybrid catfish was 15.80 and 24.06% larger than non-transgenic channel catfish control at 4 and 18 months of age, respectively. However, transgenic opAFP-ccGH channel catfish were 5.52 and 43.41% larger than channel-blue hybrid catfish and 22.19 and 77.91% larger than their controls at 4 and 18 months of age, respectively. Significant differences in mean body weight between the sexes within all genetic types were found. Males were larger than females (P < 0.001). However, mean body weight of non-transgenic males was not larger than transgenic opAFP-ccGH females or male and female hybrid catfish. Condition factor of transgenic opAFP-ccGH channel catfish was higher (P < 0.05) than that of full-sibling, non-transgenic channel catfish and hybrid catfish. The mean percentage body weight gain of GH transgenic channel catfish was 559%, the channel-blue hybrid catfish was 384.9% and their non-transgenic controls channel catfish was 352.6%.
Effect of inverted internal limiting membrane flap technique on small-medium size macular holes
Authors: Yamada Kanako , Oishi Akio , Kusano Mao , Kinoshita Hirofumi , Tsuiki Eiko , Kitaoka Takashi
Published: January 2022

Inverted internal limiting membrane (ILM) flap technique was developed to achieve macular hole (MH) closure in large MH and refractory cases. In this study, we evaluate the effect of the technique for small-medium size MH. We recruited patients who underwent vitrectomy for small-medium size (< 400 μm) MH with either inverted ILM flap technique (flap group) or with conventional ILM peeling (peeling group). Using propensity score, 21 eyes of 21 patients in the peeling group were matched against 21 eyes of 21 patients in the flap group. We compared MH closure rate, postoperative visual acuity, and recovery of the external limiting membrane (ELM) and ellipsoid zone (EZ). The MH closure rate was not different between the two groups (flap vs peeling: 90% vs 100%, P = 0.49). Whereas there was no significant difference in visual acuity improvement between the two groups, the flap group showed more disruption of the ELM 3 months after surgery and of the EZ at 3 and 6 months after surgery (P = 0.02, P = 0.03, and P = 0.04, respectively). The result suggested that inverted ILM flap technique does not have additional benefits for small-medium size MHs and may delay recovery of retinal integrity.
Temperature and interlayer coupling induced thermal transport across graphene/2D-SiC van der Waals heterostructure
Authors: Islam Md. Sherajul , Mia Imon , Islam A. S. M. Jannatul , Stampfl Catherine , Park Jeongwon
Published: January 2022

Graphene based two-dimensional (2D) van der Waals (vdW) materials have attracted enormous attention because of their extraordinary physical properties. In this study, we explore the temperature and interlayer coupling induced thermal transport across the graphene/2D-SiC vdW interface using non-equilibrium molecular dynamics and transient pump probe methods. We find that the in-plane thermal conductivity κ deviates slightly from the 1/T law at high temperatures. A tunable κ is found with the variation of the interlayer coupling strength χ. The interlayer thermal resistance R across graphene/2D-SiC interface reaches 2.71 $$\times$$
×
10–7$${\text{Km}}^{2} /{\text{W}}$$

Km

2

/
W

at room temperature and χ = 1, and it reduces steadily with the elevation of system temperature and χ, demonstrating around 41% and 56% reduction with increasing temperature to 700 K and a χ of 25, respectively. We also elucidate the heat transport mechanism by estimating the in-plane and out-of-plane phonon modes. Higher phonon propagation possibility and Umklapp scattering across the interface at high temperatures and increased χ lead to the significant reduction of R. This work unveils the mechanism of heat transfer and interface thermal conductance engineering across the graphene/2D-SiC vdW heterostructure.
Non-conventional superconductivity in magnetic In and Sn nanoparticles
Authors: Ma Ma-Hsuan , Batsaikhan Erdembayalag , Chen Huang-Nan , Chen Ting-Yang , Lee Chi-Hung , Li Wen-Hsien , Wu Chun-Ming , Wang Chin-Wei
Published: January 2022

We report on experimental evidence of non-conversional pairing in In and Sn nanoparticle assemblies. Spontaneous magnetizations are observed, through extremely weak-field magnetization and neutron-diffraction measurements, to develop when the nanoparticles enter the superconducting state. The superconducting transition temperature TC shifts to a noticeably higher temperature when an external magnetic field or magnetic Ni nanoparticles are introduced into the vicinity of the superconducting In or Sn nanoparticles. There is a critical magnetic field and a critical Ni composition that must be reached before the magnetic environment will suppress the superconductivity. The observations may be understood when assuming development of spin-parallel superconducting pairs on the surfaces and spin-antiparallel superconducting pairs in the core of the nanoparticles.
A ninety-six well plate as headspaces with moist starch indicator paper as a cover for the determination of ascorbic acid by iodate oxidation and formation of volatile iodine
Authors: Nawalohakul Thichaphat , Charoenjiraroj Pannarat , Chantiwas Rattikan , Wilairat Prapin , Praditweangkum Wiboon
Published: January 2022

A new and simple headspace colorimetric assay was developed for the analysis of ascorbic acid via iodate oxidation generating liberated iodine vapor.
Guanidinium substitution-dependent phase transitions, ionic conductivity, and dielectric properties of MAPbI3
Authors: Minussi F. B. , Bertoletti E. M. , Reis S. P. , Carvalho J. F. , Araújo E. B.
Published: January 2022

We report GA+ substitution-induced phase transitions in MAPbI3, reduced ionic conductivities and dielectric permittivities, and increased slow relaxation times.
Enantiopure ferrocene-1,2-disulfoxides: synthesis and reactivity
Authors: Wen Min , Erb William , Mongin Florence , Blot Marielle , Roisnel Thierry
Published: January 2022

The first members of the enantiopure ferrocene-1,2-disulfoxide family are described as well as their unprecedented use as ligands in asymmetric conjugate addition.
Mechanochemical synthesis of crystalline U(vi) triperoxide solids
Authors: Kravchuk Dmytro V. , Forbes Tori Z.
Published: January 2022

Mechanochemical reaction of UO3 with metal peroxides (M2O2) yields U(vi) triperoxide materials without producing radioactive solvent wastes.
Effect of poly(acrylic acid) on crystallization of calcium carbonate in a hydrogel
Authors: Kim Hong Lyun , Shin Yu Seob , Yang Sung Ho
Published: January 2022

As carbonate ions are diffused into an agarose hydrogel containing calcium ions and poly(acrylic acid), elliptical and spherical calcites are controllably formed depending on the concentration of poly(acrylic acid) and the position of the hydrogel.
Detection of extremely large magnetoresistance in a ring-shaped array of magnetic quantum dots with very high performance and controllable parameters
Authors: Faizabadi Edris , Molavi Mohammad
Published: January 2022

Using a Green's function method, we study the magnetoresistance (MR) effect in a ring-shaped array of magnetic quantum dots (QDs), with or without magnetic leads, while the magnetic QDs play the role of magnetic layers in conventional multilayer MR devices.
CO2 reduction on single-atom Ir catalysts with chemical functionalization
Authors: Lin Zheng-Zhe , Li Xi-Mei , Chen Xin-Wei , Chen Xi
Published: January 2022

Defect-free functionalization by IrX3 (X = F or Cl) on the MoS2 monolayer as CO2RR catalysts with a low onset potential.
BODIPY–pyrene donor–acceptor sensitizers for triplet–triplet annihilation upconversion: the impact of the BODIPY-core on upconversion efficiency
Authors: Kiseleva Natalia , Filatov Mikhail A. , Fischer Jan C. , Kaiser Milian , Jakoby Marius , Busko Dmitry , Howard Ian A. , Richards Bryce S. , Turshatov Andrey
Published: January 2022

BODIPY–pyrene heavy-atom-free donor–acceptor dyads are effective sensitizers for TTA-UC, with the highest TTA-UC quantum yield of 6.9% observed for the dyad with an unsubstituted BODIPY scaffold.
Dielectric barrier discharge plasma grafting carboxylate groups on Pt/Al2O3 catalysts for highly efficient hydrogen release from perhydro-dibenzyltoluene
Authors: Shi Libin , Zhou Yiming , Tan Xiao , Qi Suitao , Smith Kevin J. , Yi Chunhai , Yang Bolun , Liu Shida
Published: January 2022

The carboxylate groups on Pt/Al2O3 catalysts increase the proportion of Pt (1 1 1) and Pt (1 0 0) planes that facilitate H18-DBT dehydrogenation.
Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly™ bread in celiac subjects: a randomized, double blind, placebo controlin vivostudy
Authors: Andriulli Angelo , Bevilacqua Antonio , Palmieri Orazio , Latiano Anna , Fontana Rosanna , Gioffreda Domenica , Castellana Stefano , Mazza Tommaso , Panza Anna , Menzaghi Claudia , Grandone Elvira , di Mauro Lazzaro , Decina Ivana , Tricarico Michele , Musaico Daniela , Mäki Markku , Isola Jorma , Popp Alina , Taavela Juha , Petruzzi Leonardo , Sinigaglia Milena , Rosaria Corbo Maria , Lamacchia Carmela
Published: January 2022

Gluten Friendly™ (GF) is a new gluten achieved through a physicochemical process applied to wheat kernels. The goal of this research was to assess thein vivoeffects of Gluten Friendly™ bread on celiac gut mucosa and microbiota.
Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood
Authors: Sakuma Miyuki , Wang Xiao , Ellett Felix , Edd Jon F. , Babatunde Kehinde Adebayo , Viens Adam , Mansour Michael K. , Irimia Daniel
Published: January 2022

We measure intact neutrophil extracellular traps (NETs) in a drop of blood.
Versatile memristor for memory and neuromorphic computing
Authors: Guo Tao , Pan Kangqiang , Jiao Yixuan , Sun Bai , Du Cheng , Mills Joel P. , Chen Zuolong , Zhao Xiaoye , Wei Lan , Zhou Y. Norman , Wu Yimin A.
Published: January 2022

The memristor is a promising candidate to implement high-density memory and neuromorphic computing.
Nanoparticle protein corona evolution: from biological impact to biomarker discovery
Authors: Kamaly Nazila , Farokhzad Omid C. , Corbo Claudia
Published: January 2022

The pathway of the protein corona. From understanding toward exploitation through its use for biomarkers discovery.
New classes of functionalized parylenes and poly(phenylene vinylene)s via coupling of dihaloxylyl diesters
Authors: Lyu Jihong , Bielawski Christopher W.
Published: January 2022

New classes of poly(p-xylylene)s and poly(p-phenylene vinylene)s were synthesized and studied.
Pentacoordinate cobalt(ii) single ion magnets with pendant alkyl chains: shall we go for chloride or bromide?
Authors: Juráková Jana , Dubnická Midlíková Jana , Hrubý Jakub , Kliuikov Andrii , Santana Vinicius Tadeu , Pavlik Ján , Moncoľ Ján , Čižmár Erik , Orlita Milan , Mohelský Ivan , Neugebauer Petr , Gentili Denis , Cavallini Massimiliano , Šalitroš Ivan
Published: January 2022

Four pentacoordinate Co(ii) based single ion magnets were prepared and their structural, spectral, and static and dynamic magnetic properties were analysed in detail.
A nucleation-tuned mechanism to prepare centre-crossed zeolite lamellas by the rotating/static switch crystallization strategy
Authors: Wang Jing , Zhang Xinlan , Chen Lihua , Lu Xinhuan , Xia Qinghua , Zhou Dan
Published: January 2022

Controllable synthesis of zeolite lamellas with different morphology and property by tuning the nucleation process.
Samarium(ii)-electrocatalyzed chemoselective reductive alkoxylation of phthalimides
Authors: Zhang Yu-Feng , Mellah Mohamed
Published: January 2022

The unprecedented samarium electrocatalyzed reductive alkoxylation of phthalimides in a single step is presented.
Ion-doped mesoporous bioactive glass: preparation, characterization, and applications using the spray pyrolysis method
Authors: Workie Andualem Belachew , Sefene Eyob Messele
Published: January 2022

Bioactive glasses (BAG) are one type of biomaterial that is used in dentistry and orthopedics to repair or replace damaged bone. The spray pyrolysis process is low-cost and one of the most common ways for producing porous films and films with high-density packing and particle homogeneity.
Enzymatic synthesis of 2-phenethyl acetate in water catalyzed by an immobilized acyltransferase from Mycobacterium smegmatis
Authors: Li Huan , Qin Feng , Huang Lijuan , Jia Wenjing , Zhang Mingliang , Li Xin , Shu Zhengyu
Published: January 2022

Although water is an ideal green solvent for organic synthesis, it is difficult for most biocatalysts to carry out transesterification reactions in water because of the reversible hydrolysis reaction.
Hydrodeoxygenation of 2,5-dimethyltetrahydrofuran over bifunctional Pt–Cs2.5H0.5PW12O40catalyst in the gas phase: enhancing effect of gold
Authors: Althikrallah Hanan , Kozhevnikova Elena F. , Kozhevnikov Ivan V.
Published: January 2022

Addition of gold to the Pt–CsPW catalyst has an enhancing effect on the HDO of DMTHF, with a twofold increase of turnover rate at Pt sites.
EDOT-based conjugated polymers accessed via C–H direct arylation for efficient photocatalytic hydrogen production
Authors: Tan Zhi-Rong , Xing Yu-Qin , Cheng Jing-Zhao , Zhang Guang , Shen Zhao-Qi , Zhang Yu-Jie , Liao Guangfu , Chen Long , Liu Shi-Yong
Published: January 2022

The excellent reactivity toward C–H direct arylation, water wettability and O–C p–π conjugation endow EDOT to be an attractive electron donor unit for CP photocatalysts, yielding an unprecedented hydrogen evolution rate up to 0.95 mmol h−1/6 mg catalyst.
One-step integration of amorphous RuBx and crystalline Ru nanoparticles into B/N-doped porous carbon polyhedra for robust electrocatalytic activity towards the HER in both acidic and basic media
Authors: Tang Jie , Wang Biao , Zhang Yanzheng , Zhang Xiaohua , Shen Qinghui , Qin Junfeng , Xue Song , Guo Xi , Du Cuicui , Chen Jinhua
Published: January 2022

Amorphous RuBx and crystalline Ru nanoparticles integrated into B/N-doped porous carbon polyhedra via a facile one-step thermal-reduction exhibited remarkable HER electrocatalytic performances in both alkaline and acidic media.
Correction: Two-dimensional conjugated metal–organic frameworks (2D c-MOFs): chemistry and function for MOFtronics
Authors: Wang Mingchao , Dong Renhao , Feng Xinliang
Published: January 2022

Correction for ‘Two-dimensional conjugated metal–organic frameworks (2D c-MOFs): chemistry and function for MOFtronics’ by Mingchao Wang et al., Chem. Soc. Rev., 2021, 50, 2764–2793, DOI: 10.1039/D0CS01160F.
Experimental evaluation of a new carrier‐based modulation method for a three‐level T‐type quasi‐impedance‐source inverter
Authors: Gutiérrez‐Escalona Javier , Roncero‐Clemente Carlos , Barrero‐González Fermín , Husev Oleksandr , González‐Romera Eva , Milanés‐Montero María Isabel
Published: January 2022

Quasi‐impedance‐source inverter topologies require the insertion of short‐circuit states of the DC‐link to achieve the boost feature. Unlike traditional strategies that implement full short‐circuits in the legs of the inverter, new control methods based on space vector modulation (SVM) introduce these states by alternately short‐circuiting the two halves of the DC‐link, improving the harmonic performance and efficiency of the converter. However, because of the complexity involved in the implementation of these SVM strategies, simpler and more direct control techniques are needed. In this study, a new carrier‐based strategy for the control of a three‐level T‐Type quasi‐Z‐source inverter (qZS 3L‐TI), which implements the half‐DC‐link short‐circuit states, is validated through several experimental tests under rated power conditions. The experimental results indicate that the new carrier‐based technique shows improved harmonic performance, lower semiconductor stress, and a better efficiency than the traditional full shoot‐through strategy. Based on these results and the simplicity of implementation, the new carrier‐based control strategy proves to be a competitive alternative for the control of qZS 3L‐TI.
Sustainable animal genetic improvement
Authors: van der Werf Julius H. J.
Published: January 2022

Well designed and targeted animal breeding programs allow a sustainable genetic improvement of livestock with increases in animal productivity of 1-2% per annum. Over time, massive improvements have been achieved, e.g. in dairy and pig and poultry production systems, now resulting in higher production that requires much fewer input of resources. Although reproductive and genomic technologies contribute nowadays to increases in rates of genetic improvement, the key to successful breeding programs lies in a strong focus on simple and well-defined breeding objectives, effective investment in trait measurement, a clear understanding of the structure of the breeding program, and efficient systems for genetic evaluation, selection and mating of elite animals. The dissemination of the genetics of selected animals to the wider population also needs consideration, requiring commercial farmers or smallholders to have the means to have access to improved genetics as well as an understanding of the value of using improved bulls. Definition of the breeding objectives as well as evaluation of genetic merit needs to be based on the local environment. Compared with other interventions to improve productivity and stability, genetic improvement is a critical and cost-effective approach as genetic gains are permanent and cumulative.
Effect of dietary inclusion of black soldier fly larvae (Hermetia illucens) on broiler performance: A meta-analysis
Authors: Nayohan Sandi , Susanto Irwan , Permata Dessy , Pangesti Raiza Tri , Rahmadani Mardiah , Jayanegara Anuraga
Published: January 2022

Black Soldier Fly (BSF, Hermetia illucens) is an insect species that potentially can be used as a protein source for broiler nutrition. This study aimed to evaluate different inclusion level of BSF on broiler performance and blood metabolites by integrating various data from related studies using meta-analysis. Total of 12 studies that comprised of 31 data points were integrated in the database. Parameters observed included Live Weight (LW), Average Daily Gain (ADG), Daily Feed Intake (DFI), Feed Conversion Ratio (FCR), blood metabolites, and carcass proportion. The database was statistically analyzed by using mixed model method. Different studies were considered as random effects, and the level of BSF was treated as fixed effects. The model statistics used were the p-values and the Akaike information criterion. The significance of an effect was stated when its p-value was < 0.05. The results revealed that BSF feeding had significant linearly reduction effect on LW, ADG, and FCR of broiler (P < 0.05) and significant linearly increase effect on DFI and carcass proportion. However, BSF did not significantly affect on blood metabolites of broilers. It can be concluded that BSF negatively affect the performance of broiler.
Phylogenetic tree analysis for Bali Cattle based on partial sequence 16S rRNA Mitochondrial DNA
Authors: Misrianti R. , Wijaya S.H. , Sumantri C. , Jakaria J.
Published: January 2022

Mitochondria DNA (mtDNA) as a source of genetic information based on the maternal genome, can provide important information for phylogenetic analysis and evolutionary biology. The objective of this study was to analyze the phylogenetic tree of Bali cattle with seven gene bank references (Bos indicus, Bos taurus, Bos frontalis, andBos grunniens) based on partial sequence 16S rRNA mitochondria DNA. The Bayesian phylogenetic tree was constructed using BEAST 2.4. and visualization in Figtree 1.4.4 (tree.bio.ed.ac.uk/software/figtree/). The best model of evolution was carried out using jModelTest 2.1.7. The most optimal was the evolutionary models GTR + I + G with p-inv (I) 0,1990 and gamma shape 0.1960. The main result indicated that the Bali cattle were grouped intoBos javanicus. Phylogenetic analysis also successfully classifyingBos javanicus, Bos indicus, Bos taurus, Bos frontalisandBos grunniens. These results will complete information about Bali cattle and useful for the preservation and conservation strategies of Indonesian animal genetic resources.
Physicochemical quality of low fat mayonnaise using whey protein concentrate
Authors: Satriawan Tri Umar , Evanuarini Herly , Thohari Imam
Published: January 2022

Low fat mayonnaise as a low-calorie product modification has low emulsion stability. Whey Protein Concentrate (WPC) has a high protein content and can act as a good emulsifier for emulsion of mayonnaise. The purpose of this study was to evaluate of a low-fat mayonnaise using WPC based on pH, moisture content, viscosity, and protein content. The materials used are egg yolk, sunflower seed oil, vinegar, WPC, and other complementary materials. This study used a laboratory experiment with a completely randomized design with 4 treatments and 4 replications. The treatment using control treatment without additional use of WPC and treatments using WPC as much as 5%, 10%, and 15% of the total oil use. The variables measured were pH, moisture content, viscosity, and protein. The results showed that the use of WPC in mayonnaise gave significantly different on pH, moisture content, viscosity, and protein content. The conclusion of this research that the use of WPC as much as 15% produces the best low fat mayonnaise.
Productivity of Benggala grass (Panicum maximum) at different ages of oil palm
Authors: Fanindi Achmad , Sajimin Sajimin , Sutedi Endang , Herdiawan Iwan , Harmini Harmini
Published: January 2022

The study aimed to observe the cultivars of Benggala grass grown at different ages of oil palms. The research was conducted at the location of oil palm plantations at the Sei Putih, Deli Serdang, North Sumatra. The study used a Factorial Completely Randomized Block Design, using 3 replications, the first treatment was 2 oil palm planting ages, namely the age of fewer than 5 years and more than 5 years plus control (open space), while the second treatment was 5 cultivars of Benggala grass consisting of the Hamil, Riversdale, Natsuyutaka, Gatton and Petrie. The observed variables were morphological and reproductive characters. The results showed that the fresh and dry weight of the Benggala grass cultivars decreased at the age of oil palms less or more than 5 years when compared to the control (P > 0.05). Hamil and Riversdale cultivars had better yield than other cultivars (P > 0.05). The agronomic and reproductive characteristics of Benggala grass planted in the shade of oil palm showed a decrease when compared to open land. The decrease in Benggala grass production in shade indicates the need to assemble Benggala grass cultivars in oil palm shade.
Ruminal profile of completed feed as influenced by myristic and tannins addition
Authors: Chuzaemi Siti , Qur’any Iftitah Nuzulia
Published: January 2022

The study aimed to determine the effect of adding tannin and myristic acid in complete feed on nutrient content and the Profile of volatile fatty acids (VFA) in vitro. The materials used for this research were corn straw, condensed tannins, myristic acid, coffee waste, rice bran, tapioca byproduct, soybean meal, copra meal, and palm kernel meal. The method was used in this experiment was laboratory experiment with four treatments and three replications. The treatment consisted of T1 complete feed (40% corn straw + 60% concentrate (be based DM)), T2 (complete feed + condensed tannins 3%/kg DM and myristic acid 2%/kg DM), T3 (complete feed + condensed tannins 3%/kg DM and myristic acid 3%/kg DM), and T4 (complete feed + condensed tannins 3%/kg DM and myristic acid 4%/kg DM). Every treatment was repeated three times and analysed statistically using Randomized Block Design (RBD). The adding of 4% myristic acid to the complete feed (T4) gives the best results, it increased nutrition and propionic acid, but decreased acetic acid, butyric acid, total VFA and C2/C3 ratio.
Effect of forage Legetan (Synedrella nodiflora) fresh and hay on the physical quality of forage pellets
Authors: Suwignyo Bambang , Subagya Rifqi Danang , Astuti Andriyani , Umami Nafiatul , Agus Ali
Published: January 2022

This study aimed to determine the effect of raw materials Legetan in the form of fresh and hay on the physical quality of pellets. Legetan (Synedrella nodiflora) was used as main ingredient, in the form of fresh and hay. The research method used a Randomized Completely Block Design (RCBD). Then, if there was a significant difference, it will be analyzed further using Duncan multiple range test (DMRT). The treatments consisted of P1 = 10% rice bran + 90% fresh Legetan; P2 = 20% rice bran + 80% fresh Legetan; P3 = 10% rice bran + 90% hay Legetan; P4 = 20% rice bran + 80% hay Legetan. The variables measured were rendement, color, texture, and price. The results showed that the utilization of Legetan forage as raw material, both hay and fresh with the proportions of rice bran either 10:90 or 20:80, had no significant effect on the physical quality of Legetan forage pellets. However, the higher the portions of Legetan forage in the forage pellets, the more affordable the pellet price will be.
A review chromosome analysis comparison of swamp buffalo (Bubalus bubalis) with different phenotypic characters in East Java, Indonesia
Authors: Putri Ardyah Ramadhina Irsanti , Ciptadi Gatot , Budiarto Agus , Rahayu Sri , Karima Helly Nurul , Susiati  , Finawati Perdana , Mudawamah  , Oktanella Yudit
Published: January 2022

Chromosomal data on swamp buffalo especially in East Java province, is still lacking. For breeders, chromosomal analysis needs to be done to detect the possibility of hereditary genetic defects. In Malang Area, farmers lack of care and breeding programs for swamp buffalo also caused a decline in the genetic quality and performance. The purpose of this study was to compare the results of the chromosome analysis of swamp buffalo in Malang and another area in East Java province, which were selected based on differences in phenotypic characters. Chromosome analysis is very important for breeders because the results of this study can be used as a consideration for strategies to improve the genetic quality of swamp buffalo. The method used is standard karyotyping using whole blood with G banding staining. Chromosomal preparation using Karyo MAX medium, Colcemic Solution, Giemsa Stain, and KCl solution. Cell culture was performed according to the standard karyotyping method in mammals. The minimum number of 5 spreading chromosomes is the best was chosen, microphotographed, and then chromosome analysis is performed using Cytovision Image Analysis software. The results of this study did not find swamp buffalo with an abnormal number of chromosomes in East Java Province, Indonesia.
In-vitro nutrient degradability of complete feed containing myristic acid and tannins addition
Authors: Ndaru Poespitasari Hazanah , Chuzaemi Siti , Mufidah Muhimmatu
Published: January 2022

The purpose of this research was to determine the influence of Myristic acid and the source of condensed tannin on corn straw basedcomplete feed on nutrient content and in vitro digestibility. The method which was used in this experiment was randomized block design with four treatments and three replications. The treatment consisted of T0 complete feed (40% corn straw + 60% concentrate), T1 complete feed (40% corn straw + 60% concentrate + myristic acid 30 g/Kg DM), T2 complete feed (40% corn straw + 50% concentrate + calliandra leaf meal 10%/Kg DM and myristic acid 30 g/Kg DM), T3 complete feed (40% corn straw + 45% concentrate + calliandra leaf meal 15%/Kg DM and myristic acid 30 g/Kg DM), T4 (40% corn straw + 40% concentrate + calliandra leaf meal 20%/Kg DM and myristic acid 30 g/Kg DM). Based on the result, it could be concluded that calliandra leaf meal 15%/Kg DM + Myristic acid 30 g/Kg DM on the complete feed (T3) was the best treatment based on nutrient content and increase of dry matter digestibility, but not an effect of organic matter digestibility
Effect of fermentation on mixed rumen contents and jackfruit peel using Aspergillus oryzae on in vitro gas production and digestibility
Authors: Mashudi Mashudi , Nurmawati Wahyuni
Published: January 2022

The objective of this research was to investigate the effect of Aspergillus oryzae on fermentation of mixture of rumen contents and jackfruit peel on in vitro gas production and digestibility. The method used in this study was an experiment using a randomized block design (RBD) of 4 treatments and 3 replications. The treatments including of T0 = 50% rumen contents + 50% jackfruit peel, T1 = 40 % rumen contents + 60% jackfruit peel + 0,4% Aspergillus oryzae, T2 = 30% rumen contents + 70% jackfruit peel + 0,4% Aspergillus oryzae, T3 = 20% rumen contents + 80% jackfruit peel + 0,4% Aspergillus oryzae. Variables observed were gas production, dry matter digestibility (DMD), and organic matter digestibility (OMD). Data were analyzed by using Analysis of Variance (ANOVA) from Randomized Block Design, if there were significant effect between the treatments then tested with least significant different (LSD). The result showed that fermentation of mixture of rumen contents and jackfruit peel have highly significant effect (P<0.01) on gas production, and significant effect (P<0.05) on DMD and OMD. Gas production, DMD and OMD of fermented mixture of rumen contents and jackfruit peel are higher than control without fermentation. It is concluded that the higher jackfruit peels the higher gas production, DMD and OMD.
Evaluation of qualitative characteristics of Bali cattle at Bali breeding center
Authors: Azis Rosidi , Nurgiartiningsih Veronica Margareta Ani , Wahjuningsih Sri , Sudarwati Herni , Furqon Ahmad
Published: January 2022

The aim of this study was to identify the qualitative characteristics of Bali cattle at Bali Breeding Center. The samples used were 136 heads. Qualitative data was analysed based on the percentage for each trait and analyzed descriptively. The results showed that the characteristic with the highest percentage were brick red for females of Bali cattle (84,81%), black for males Bali cattle (86.66%), dominant thick back line (79.74%) for females, while on males was not clear (86,67%), strict line of body color border with leg (100% for males and 91,14% for females), strict line of body color border with buttocks color (93,33% for males and 88,61% for females), white of edge lips color (95% for males and 93,67% for females), black eyelid color (100%), white ear hair color (males: 100% & females: 96,20%), dark circles on the ears (98.73%), dominant medium wattle for males (93,33%) & small wattle for females (53,16%), upwards horn (males: 100% & females: 94.93%), black tail feathers (males: 100% & females: 98.04%), and no hump (males: 96.66% & females: 100%). The qualitative characteristics of Bali cattle at Bali breeding center were in line with Indonesian National Standard. However, there were deviations and abnormality with a small percentage.