bluuebunny/crossref_metadata_2025 huggingface dataset:
Cloning, expression and anticancer activity of azurin from Pseudomonas aeruginosa VTCC-B-657
Authors: Trinh Dinh Kha , Nguyen Thi Thao , La Thi Huyen , Nguyen Thi Thu Huyen , Do Thi Tuyen
Published: January 2023

Azurin, a small molecular weight protein produced by Pseudomonas aeruginosa and several gram-negative bacteria has received considerable attention because of its potential anti-parasitic, anti-viral and anti-cancer activity. In this study, 437 bp-gene of azurin was amplified and cloned from Pseudomonas aeruginosa VTCC-B-657. This gene was then inserted into the PET22b+ vector and the recombinant plasmid was introduced into Escherichia coli BL21(DE3) by chemical methods. The recombinant strain was checked by polymerase chain reaction method and sequencing analysis. Next, the recombinant azurin (r-Azu) was expressed and purified by Ni2+-ProBondTM resin column. The molecular mass of purified r-Azu was 16 kDa when determined by SDS-PAGE and was 13.88 kDa when determined by LC/MS. Interestingly, the purified r-Azu showed cytostatic activity only on breast cancer cell lines (MCF-7 and MDA with IC50 of 25.4 and 29.25 μg/ml respectively) but not on normal cells. These results suggest that r-Azu would be a potential candidate for anticancer drugs and deserves further study.
Investigations of hemolytic activity and iron utilization sources of Vibrio alginolyticus ATCC 17749
Authors: Vibhuti Raj Kamal , Pramanik Avijit
Published: January 2023

As iron plays an indispensable role in the various physiological process with the exception of Borrelia burgdorferi, it is a vital but constrained micronutrient. It is anticipated that the capability of this possible human pathogenic organism to use iron will be crucial for both the establishment of an infection in its hosts and for survival in the habitat. The current study aimed to determine the iron utilization spectrum and hemolytic activity of Vibrio alginolyticus ATCC 17749. The ability of V. alginolyticus ATCC 17749 to utilize iron-containing compounds was tested by agar plate growth promotion assay. It was also confirmed by liquid growth promotion assay where iron was restricted by 400 μM 2,2’-Bipyridyl. After that various iron sources of concentrations ranging from 0.1 μM to 10 μM were added for growth promotion of V. alginolyticus. Ferrous sulfate, ferrioxamine and hemin stimulated the growth of V. alginolyticus as a sole iron source while catechol and ferric dicitrate did not stimulate growth. Vibrio alginolyticus supernatant was found to be hemolytic and on the blood agar plate, V. alginolyticus ATCC 17749 showed a hemolytic zone. According to our research, hemolysin synthesis is strongly influenced by the iron concentration of the growth medium. Hemin is used as the only source of iron and hemolysis might represent virulence traits of Vibrio alginolyticus. Iron utilization systems might be a potential target for antibiotics or a controlling point for hemolysin expression.
A Systematic Review on Edible Vaccines
Authors: Polshettiwar Satish A. , Khatavkar Swarupa , Vaidehi Gautam , Chandorkar Purva , Shastri Aarti
Published: January 2023

Edible vaccines are promisingly cheaper, easy to take in, safe and easily stored, fool-proof and socially justifiable, especially in poorly developed countries. These vaccines are made by inserting the necessary genes into the plants, which result in the production of the requisite encoded proteins. This concept was introduced ten years ago, but now this has become a reality. A large variety of drug delivery systems have been developed till today. Initially, it was considered to be used only to prevent infectious diseases, but now it is also used as a preventive measure for autoimmune diseases, oncotherapy, family planning etc. Many edible vaccines are currently produced for a variety of human and animal diseases. The concept of transgenic crops is increasingly embraced in industries as well as in developing countries. The fate of edible vaccines may be influenced due to opposition to genetically altered foods. The major obstacles in the approach of the upcoming vaccine technology are already overcome. But the technical hurdles, regulatory and non-scientific confrontations are yet to be subdued. This review attempts to explore the present-day stature and the upcoming scope of these new methods of prevention.
Extraction and quantification of 1-Deoxynojirimycin in Silkworm during metamorphosis and moulting stages
Authors: Sharmila Banu G. , Latha R.
Published: January 2023

The contents of 1-deoxynojirimycin (1-DNJ) in the silkworm, Bombyx mori, were examined using reverse-phase high-performance liquid chromatography at various developmental stages. Mulberry leaves and silkworms naturally contain 1-deoxynojirimycin (DNJ). Although the contents of DNJ and its actions in mulberry leaves have been studied for decades, the content of DNJ in silkworms and its use have received less attention. DNJ was extracted and quantified in a variety of silkworms including Tasar silkworms, Muga silkworms, Eri silkworms and Mulberry silkworms. Group VI silkworms are more active than the others. Then, for male and female larvae of silkworm species, the variation in DNJ contents was examined. Silkworm larvae's 1-DNJ concentration varies greatly depending on their developmental stage. Male larvae (133.25 ± 11.45 mg/100g) and female larvae (129.65 ± 10.25 mg/100g) are substantially higher in both male and female mulberry silkworms. The larvae of the 3rd and the 5th day were used to calculate the DNJ. Male larvae had a higher 1-DNJ accumulation efficiency than females and there was also a significant difference between silkworm strains. The current findings demonstrate that 1-DNJ tissue distribution is substantially increased in the blood, intestinal juice and the alimentary canal while none was found in the silk gland. Furthermore, 1-DNJ was not detected in silkworms fed with an artificial diet devoid of mulberry leaf powder. This shows that silkworms get 1-DNJ from mulberry leaves; they could not make it on their own. During the larval stage, the storage and excretion of 1-DNJ fluctuate. 1-DNJ was not found in newly hatched larvae and it was primarily accumulated during the early and middle stages of each instar, before being expelled at later stages. Furthermore, 1-DNJ can be extracted from larval excrement, making it ideal for the development of 1-DNJ-related goods.
Hydride-Enhanced Plating and Stripping of Aluminum from Triflate -Based Organic Electrolytes
Authors: Slim Zaher , Menke Erik
Published: January 2023

In the quest for developing rechargeable aluminum (Al) batteries, reversible Al electrodeposition in the absence of active-halide components (haloaluminate complexes such as, Al2Cl7–, AlCl4–, solvated AlCl3, and halide-anions such as, F–, Cl– and Br–) is considered an immense challenge. For this reason, the choice of electrolyte has been primarily limited to the highly corrosive chloroaluminate systems based on aluminum trichloride (AlCl3). In this work, we demonstrate reversible room-temperature Al plating from an active-halide-free (AHF) organic electrolyte based on aluminum trifluoromethanesulfonate (Al(OTF)3) and lithium aluminum hydride (LiAlH4) in tetrahydrofuran (THF), as well as its AlCl3 counterpart. Cyclic voltammetry measurements on a gold working electrode reveal oxidative stability of ca. 1.8 V (vs Al/Al3+). From insights obtained by DFT and FTIR, ionic speciation in the electrolyte is explored, and mechanisms for the underlying electrochemical processes in the OTF–-based electrolytes are proposed. Al electrodeposition and stripping were confirmed by optical microscopy, scanning electron microscopy (SEM) and X-ray Diffraction (XRD) spectroscopy. Characterizing the Al deposits from either the OTF–- or the Cl–-based electrolytes via depth-profile X-ray Photoelectron Spectroscopy (XPS) analyses, we find that these deposits consist of metallic Al, aluminum oxide (Al2O3), and either aluminum trifluoride (AlF3) or aluminum trichloride (AlCl3) contaminants arising from a reaction with the electrolyte components which occurs during the electrodeposition process.
Epidermis-Inspired Porous Polymer Films Grown in situ from Hydrogel Surfaces
Authors: Zhang Mengnan , Hakobyan Karen , Pan Kaiqi , Peng Shuhua , Wu Shuying , Hao Xiaojing , Jiang Zhen , Liang Kang , Xu Jiangtao
Published: January 2023

The outmost layer of skin epidermis comprises of nanostructured corneocytes embedded in extracellular lipid matrix that endows the epidermis with permeative and protective properties. Inspired by such structure, here we produced multifunctional porous polymer films on hydrogels by a simple yet robust in situ interfacial precipitation polymerization of specific water-soluble monomers that become insoluble as they polymerize. This was applied on diverse hydrogel substrates, yielding unusually durable interfaces which exhibited epidermis-like characteristics. For example, the polymer films possess a thickness of 20 to 330 µm and comprise of interconnected nanoparticles tightly bonded to hydrogel surfaces, which structurally resemble the layer of interlocked corneocytes in the epidermis. Due to these unique structural features, the film exhibits an excellent permeability towards small molecules in the first instance but can then be tailored towards effective protection from excess water loss and for enhanced electrical resistivity. These polymer films provide a platform for the development of engineered materials for diverse applications.
CHANGING STATUS OF WOMEN IN POST INDEPENDENCE INDIA
Authors: K Velumani
Published: January 2023

Without women nothing is possible for men. A woman is the basic unit of society. A country cannot progress until and unless its women take initiatives for development works. The spread of education and self-consciousness among women has led to their progress over the period. Indian women are relatively disempowered and they enjoy lower status than that of men from times immemorial. During British rule, lots of changes were made in the economic and social structure of our society. Through the quality of life of women during this period remained more or less the same, some substantial progress was achiever eliminating inequalities between men and women. Revolutionary changes have taken place in the status of Indian women during independence movement.
Basic concepts of Human Resource Management
Authors: Azash SMD
Published: January 2023

The importance of human resources to any organization need not be over- emphasized. Human resource is the wealth of a nation and an organisation. The development process is wide and varied. In this lesson, let us understand the importance and concept of Human Resources Management (HRM)
Physical and Mechanical Properties of Bamboo Oriented Strand Board Prepared fromAlkali-Immersed Strands
Authors: Maulana Sena , Taher Tarmizi , Rianjanu Aditya , Febrina Melany , Agustina Sarah , Murda Rio Ardiansyah , Hidayat Wahyu , Bindar Yazid
Published: January 2023

In this work, the physical and mechanical properties of bamboo oriented strand board (BOSB) prepared from alkali-immersed strands were examined. The Dendrocalamus asper strands were modified with alkali treatment by immersing them in 1% sodium hydroxide solution for 1, 2, and 3 hours. Three-layers BOSBs (30 x 30 x 0.9 cm3) were prepared using phenol-formaldehyde (PF) adhesive of 8% concentration and 1% paraffin. According to JIS A 5908:2003 Standard, the physical and mechanical characteristics of BOSB were evaluated (JSA, 2003). The study showed that alkali treatment improved the dimensional stability of BOSB. Immersion in 1% sodium hydroxide solutions enhanced internal bonding (IB). The longer the immersion time, the better the WA, TS, and IB values. However, alkali treatment decreased the bending strength, i.e., modulus of elasticity (MOE) and modulus of rupture (MOR). The physical and mechanical properties of all BOSBs met the commercial standard, except the BOSBs prepared from strand with alkali immersion treatment by 1% sodium hydroxide solution for 3 hours. Alkali immersion treatment of D. asper strands for producing BOSB for 1-2 hours was still acceptable. The results could provide an alternative method to produce high-performance oriented strand board using bamboo as the raw materials.
The Effects of Reactive Oxygen and Nitrogen Species (RONS) Produced by Surface Dielectric Barrier Discharge (SDBD) Non-Thermal Plasma with Treatment Time and Distance Variations to Kill Escherichia coli
Authors: Kasa Renaldo Apriandi , Juswono Unggul Pundjung , Santjojo Dionysius J. D. H.
Published: January 2023

Research on the inactivation of Escherichia coli causing diarrheal disease using non-thermal plasma SDBD has been carried out. SDBD is a new technique for non-thermal plasma generation with several advantages: low power generation, comprehensive treatment area coverage, and reducing the potential effects of burning and drying tissue. This study aimed to analyze the effect of treatment time variations, namely 0 as control, 60, 75, 90, 105, and 120 seconds and treatment distance variations of 3, 6, 9, 12, and 15 mm of non-thermal plasma treatment of SDBD on E. coli. The results of the non-thermal plasma SDBD treatment with variations in time and distance showed that the longer the treatment time, the more bacterial cells died. Colony counts decreased to 4.33 x 107 CFU/mL compared to the control, 409 x 107 CFU/mL, with a treatment time variation of 120 seconds, yielding the best treatment results. At the same time, the results of the treatment for variations in the non-thermal plasma distance of SDBD showed that the smaller the treatment distance, the greater the bacterial death rate, with the best treatment results at a 3 mm treatment interval, with colony counts of 8 x 107 CFU/mL, compared to 409 x 107 CFU/mL in control. Based on these results, SDBD non-thermal plasma treatment can be used to inactivate or kill bacteria with effectiveness in killing bacteria depending on the length of treatment time and the distance of treatment.
Determination of (+)-Catechin and Antioxidant Activity in Faloak (Sterculia quadrifida R. Br) Stem Bark Infusion
Authors: Riwu Audrey Gracelia , Nugraha Jusak , Purwanto Djoko Agus , Triyono Erwin Astha
Published: January 2023

Oxidative stress is a condition that can damage human cells and tissues and has been linked to a number of illnesses, including cancer, cardiovascular disease, autoimmune disorders, and neurological diseases. Oxidative stress conditions can be brought on by pollution, radiation exposure, and an unhealthy lifestyle. Antioxidants are substances that can be used to both prevent and treat oxidative stress. This study aimed to identify and quantify (+)-catechin levels and antioxidant activity of the stem bark of Sterculia quadrifida R. Br extracted by the infusion method, a method similar to traditional medicine processing generally in the community. Determination of (+)-catechin and antioxidant activity of S. quadrifida were evaluated by HPLC and DPPH assay, respectively. Quantification of (+) catechin content by HPLC system with wavelength 280 nm and antioxidant activity by spectrophotometry method with wavelength 517 nm. The results show that the mean value of (+)-catechin level was 7.786% and the IC50 value of the antioxidant activity was 51.5 ug/mL having a moderate antioxidant activity category. S. quadrifida stem bark infusion can be utilized as a medication candidate for the prevention or treatment of a variety of disorders caused by oxidative stress.
Majority Voting as Ensemble Classifier for Cervical Cancer Classification
Authors: Desiani Anita , Kresnawati Endang Sri , Arhami Muhammad , Resti Yulia , Eliyati Ning , Yahdin Sugandi , Charissa Titania Jeanni , Nawawi Muhammad
Published: January 2023

Cervical cancer is one of the deadliest female cancers. Early identification of cervical cancer through pap smear cell image evaluation is one of the strategies to reduce cervical cancer cases. The classification methods that are often used are SVM, MLP, and K-NN. The weakness of the SVM method is that it is not efficient on large datasets. Meanwhile, in the MLP method, large amounts of data can increase the complexity of each layer, thereby affecting the duration of the weighting process. Moreover, the K-NN method is not efficient for data with a large number of attributes. The ensemble method is one of the techniques to overcome the limitations of a single classification method. The ensemble classification method combines the performance of several classification methods. This study proposes an ensemble method with the majority voting that can be used in cervical cancer classification based on pap smear images in the Herlev dataset. Majority Voting is used to integrate test results from the SVM, MLP, and KNN methods by looking at the majority results on the test data classification. The results of this study indicate that the accuracy results obtained in the ensemble method increased by 1.72% compared to the average accuracy value in SVM, MLP, and KNN. for sensitivity results, the results of the ensemble method were able to increase the sensitivity increase by 0.74% compared to the average of the three single classification methods. for specificity, the ensemble method can increase the specificity results by 3.4%. From the results of the study, it can be concluded that the ensemble method with the most votes is able to improve the classification performance of the single classification method in classifying cervical cancer abnormalities with pap smear images.
The Use of Gamification in Teaching and Learning during Covid-19 Pandemic
Authors: Mertika Mertika , Fitriyadi Slamat , Mariana Dewi , Hendriana Evinna Cinda , Giovani Wanda , Anitra Rien , Utami Citra , Setyowati Rini , Susanto Heru
Published: January 2023

This service activity aims to increase the understanding and knowledge of lecturers about the use of gamification in learning during the Covid-19 pandemic. In addition, this program also provides socialization of what game models can be used to support e-learning lectures on campus, for example using learning applications such as Quiziz and Kahoot or by implementing game learning models such as role playing, NGT and others. The specific target to be achieved is to increase the creativity of lecturers in designing and using gamification in learning during the Covid-19 pandemic so that online learning becomes more fun. The method used in the implementation of this service is in the form of counseling methods, and question and answer.
Reinventing Students' Self-esteem in Classrooms: The Need for Humanistic Pedagogy
Authors: Omodan Bunmi Isaiah , Mtshatsha Nondwe
Published: January 2023

Lack of self-esteem among students makes them believe that they are not proficient enough or do not have the needed skills to succeed academically. The perceived  lack of self-esteem seems resulting from the observed anti-humanistic teaching and learning system bedevilling all levels of classrooms. Literature confirms that students lack critical thinking skills, relationship skills, and communication skills, which affect their self-esteem. This study is positioned to respond to the issue by presenting humanistic pedagogy as a teaching approach that develops students holistically. It is lensed within the purview of the transformative paradigm since it focuses on how students could be transformed towards gaining the needed self-esteem that will promote their academic, social and societal development. Humanistic Pedagogy theory was presented alongside its principles and assumptions to achieve this. How the assumptions are related to the teaching of humanism and building students' self-esteem was also presented. This study concluded that student-centred classrooms, students' feelings and values, creativity and innovation, and humanising humankind are dimensions of self-esteem development among students. This study recommends that teachers at all levels of education adopt humanistic pedagogical processes in their classrooms. 
The Effect of Teacher Competence, Online Learning Model on Student's Learning Effectiveness at State Junior High School, Telaga District, Gorontalo Regency
Authors: Sumar Warni Tune , Sulkifly Sulkifly , Lamatenggo Nina , Razak Intan Abdul
Published: January 2023

This study aims to determine the direct influence of teacher competence and online learning model on students’ learning effectiveness. It employs a survey method by applying a questionnaire. In addition, data analysis uses descriptive and inferential analysis with path analysis. The population in this study is the whole students at Grade VIII of State Junior High School throughout Telaga Subdistrict, Gorontalo Regency, in the amount of 158 students. At the same time, the samples are 88 students taken by using a proportionate stratified sampling technique. Research findings reveal that: 1) teacher competence has a direct positive influence on students’ learning effectiveness, 2) online learning model has a direct positive influence on students’ learning effectiveness, 3) teacher competence and online learning model simultaneously influence students’ learning effectiveness. As having been stated previously, the purpose of this study is to find out the influence of teacher competence and online learning model towards students’ learning effectiveness at State Junior High School throughout Telaga Subdistrict, Gorontalo Regency. High-quality education can produce quality and productive human resources so that they can compete in the competitive era of globalization. Importantly, students’ learning outcomes are a benchmark of success in learning the material. Teachers need to evaluate students’ abilities in order to figure out student learning outcomes. In other words, student learning outcomes can be perceptible from the result of the evaluation.
Principal Leadership Behavior Impact on The Character Education
Authors: Hanafiah Hanafiah , Ramazan Ramazan
Published: January 2023

The principal as the leader directly is a real example in the work activities in the school environment. This study aims to look at the principal's leadership behavior, the relationship between the principal's leadership behaviors towards strengthening the character education of vocational students. This research uses a quantitative approach, using a cross-sectional survey method. The results of this study are based on the results of data processing obtained that five school principals have good leadership behavior with a percentage of 55.56%, and four school principals have reasonably good behavior with a percentage of 44.44%. Partial test results obtained there is a relationship between the principal's leadership behavior towards strengthening the character education of vocational students on the east coast of Aceh, principal's leadership behavior 58.8% to the student's character education. Based on the results of data processing, it is obtained that from 9 vocational high schools in the eastern part of Aceh that were studied, 5 schools (55.56%) principals had good leadership behaviors, and 4 schools (44.44 %) the principal has a fairly good leadership behavior. From the partial test results obtained that there is a relationship between the principal's leadership behaviors towards the education of the character strengthening of vocational students on the coast of East Aceh.
Model for The Development of Basic Values of Science and Environmental Awareness Through The Potential of Teachers' Teaching Styles, Learning Styles and Students' Thinking Styles at The First Middle School in Cirebon City
Authors: Wahidin Wahidin , Sallu Sulfikar
Published: January 2023

Until now, teachers have not focused on developing basic science values, scientific thinking styles and environmental awareness of students in schools. Teachers in schools are preoccupied with pursuing curriculum targets for cognitive academic achievement. So the indicator of student success is measured only by academic achievement. Meanwhile, critical thinking skills, creative, innovative and students' awareness of the environment are rarely measured as learning outcomes. In the science education curriculum at LPTKs, this learning achievement has not been clearly defined. The purpose of this study is to examine the model of developing basic science values and environmental awareness through the teaching style of teachers, learning styles and thinking styles of junior high school students in Cirebon City. The research method used is the mix method. Samples were taken purposively and simple random from junior high school students who were the research targets. Data collection techniques were carried out by observation, in-depth interviews with teachers and tests on class VIII students using thinking skills test instruments and questionnaires. The results showed that the teacher's teaching style became a mental model for students in building thinking patterns, developing basic science values, and students' awareness of the surrounding environment. The science education curriculum in the LPTK environment needs to be reviewed, especially regarding the learning outcomes for the competence of prospective science teachers related to the competence to teach thinking skills and students' awareness.
Students' Attitude to The Application of The Think Talk Write Type of Cooperative Learning Learning Model Relationship with Cognitive Achievement in Islamic Educations
Authors: Nurwahdan Nurwahdan , Husna Nadia
Published: January 2023

This study aims to determine how students' attitudes toward the application of the Think Talk Write Cooperative Learning model are; how Cognitive achievement of students in Islamic Educations subjects; and how is the relationship between students' attitudes towards the application of the Think Talk Write Cooperative Learning model with their cognitive achievement in Islamic Educations subjects in eighth grade at junior high school 1 of Cianjur City. The approach in this study is quantitative, while the method used is the correlation method. Data collection techniques include observation, questionnaires, documentation, interviews and tests. The data analysis technique was carried out with a statistical approach for quantitative data. In analyzing the data that has been collected, the author uses statistical analysis by taking a partial analysis of indicators, normality test, regression test, correlation test and hypothesis testing. The results showed that, 1) The students' attitudes towards applying the cooperative learning model of think talk write type were categorized as positive with a score of 4.34. 2) Cognitive achievement of students in Islamic Educations subjects with a high category score of 83. 3) The relationship between the two variables is (a). The correlation coefficient includes an average score of 0.49 (b). The hypothesis is accepted, t_count is 7.1 and t_table is 0.2542. (c). The degree of influence of the X variable on the Y variable is sufficient, which is 74%. These results indicate that 26% of other factors can affect their cognitive achievement in Islamic Educations subjects apart from students' attitudes towards the application of the Think Talk Write Cooperative Learning learning model
EFEKTIVITAS MEDIA PEMBELAJARAN BERBASIS ANDROID MICROSOFT MATH SOLVER (MMS) TERHADAP KEMAMPUAN PEMECAHAN MASALAH DAN KEMANDIRIAN BELAJAR
Authors: Heryana Penra , Rusdiyani Isti , Nulhakim Lukman
Published: January 2023

Penelitian dilakukan sesuai dengan permasalahan dalam proses pembelajaran, yaitu (1) pembelajaran yang biasanya dilakukan tidak sepenuhnya dikuasai oleh siswa; (2) sebagai pendidik harus berinovasi sesuai tuntutan zaman; (3) penggunaan smartphone sebagai alternatif sumber belajar yang efektif; (4) penggunaan android dapat menyelesaikan masalah matematika dan meningkatkan kemandirian belajar siswa. Tujuan dari penelitian ini adalah untuk mengetahui keefektifan penggunaan media pembelajaran android Microsoft Math Software (MMS) terhadap kemampuan pemecahan masalah dan pembelajaran mandiri. Penelitian ini menggunakan desain eksperimen semu dengan desain posttest control group design. Pengumpulan data dilakukan dengan menggunakan metode observasi, angket kemandirian belajar, dan tes kemampuan pemecahan masalah. Data yang diperoleh dianalisis dan dideskripsikan untuk uji normalitas dan homogenitas, uji N-Gain Score, dan uji t. Hasil analisis menunjukkan bahwa terjadi peningkatan kemampuan pemecahan masalah pada kelas eksperimen dibandingkan dengan kelas kontrol. Hasil yang diperoleh menunjukkan bahwa kemampuan pemecahan masalah pada kelas eksperimen sebesar 72,11% berada pada kategori “Tinggi”, sedangkan pada kelas kontrol hanya 26,70% yang dinyatakan “Rendah”. Hasil angket yang diperoleh 82,62% kemandirian belajar dinyatakan dalam kategori “Tinggi”.
Cuidados Humanos como eje de la Enfermería en la Salud Comunitaria
Authors: Albornoz Zamora Elsa Josefina , Guzmán Marigina , Arteaga Yánez Yanetzi Loimig , Ortega Guevara Neris Marina , Luna Álvarez Heriberto Enrique , Castillo Castillo María Auxiliadora , Márquez de González Ana Hilda , Peraza de Aparicio Cruz Xiomara , Cañizales Jota Ana Luisa , Zurita Barrios Nhaylett Yoskyra , Zurita Barrios Bianny Evita , Chuga Guamán Jonathan Gabriel , David Salazar José , Salvador Cortez Kevin Rafael , Del Salto Tapia Wilson , Obando Ochoa Francisco David
Published: January 2023

La obra que presentamos al lector Cuidados humanos como eje de la enfermería en la salud, representa la concreción de un significativo y loable esfuerzo de investigación, y tiene como propósito ofrecer al estudiante de enfermería y al profesional de la salud interesado, unos conocimientos sólidos acerca de una amplia variedad de temas, todos relacionados con el cuidado de enfermería en diversas situaciones. A pesar de que tradicionalmente la formación universitaria en enfermería se ha ocupado de los cuidados agudos y a largo plazo, en la actualidad el ejercicio profesional de la enfermería, ha salido del recinto hospitalario para practicarse en diversos ámbitos, entre éstos y de mayor importancia, el de la familia y las comunidades; sin duda un cambio que ha favorecido la adopción de un enfoque holístico, humanizado y multidisciplinar de la atención al paciente. Son realmente amplios y diversos los temas que han de abordarse en la formación del nuevo profesional de la enfermería, así como también, son grandes los desafíos y oportunidades que en el futuro inmediato habrá de afrontar en el ejercicio de la profesión. El cuidado de los pacientes constituye la esencia y el propósito de la profesión de enfermería. Para cumplir con este designio y brindar un cuidado humanizado al paciente, el profesional de enfermería debe contar con conocimiento científico basado en evidencia, valores humanos y éticos, habilidades y destrezas prácticas, una excelente relación terapéutica con el paciente, ofrecer una atención cálida, comprometida y de óptima calidad, debe escuchar al paciente y mantener una comunicación afectiva, cuidar con empatía y mantener siempre el respeto por su dignidad.
Preservice Elementary Teachers Understanding of Fraction Multiplication and Division in Multiple Contexts
Authors: Kang Hyun Jung
Published: January 2023

The present study examined preservice elementary teachers’ performance on the problems of multiplication and division of fractions and compared their performances and analyzed the misconceptions. An instrument including 11 fraction multiplication and division tasks was given and the task involved three contexts: making own story problem, computations, representing operation using visual model. The findings reported that among the three contexts, making a diagram was the most challenging task for both operations, and their division performance varied depending on the division problem types. The author suggests that specific emphasis with rich story problem with different whole(s) in fraction, carefully designed context with different types of division concept, and building fractional number sense can help both PSTs and students reduce misconceptions and enhance deeper understanding of fraction operations.
Handwriting Speeds of 4th–8th Grade Students
Authors: Yekeler Dilek , Yıldız Mustafa , Aktaş Nurhan , Ataş Merve
Published: January 2023

For the effective expression of feelings and thoughts, handwriting should be produced fluently at a certain speed. The aim of this study was to examine the development of handwriting speeds in 4th–8th grade primary and secondary school students in terms of somevariables. In line with this aim, answers were sought to the question, “Do 4th–8th grade primary and secondary school students’ handwriting speeds differ significantly depending on their grade, gender, hand preference, and handwriting style?” The study was designed inthe survey method, and the study group consisted of 322 students attending the 4th, 5th, 6th, 7th, and 8th grades of primary and secondary school. A form developed by the researchers for all grade levels was usedas the data collection tool in the study. In the data collection process, the students were required to copy a given text within one minute. The research results revealed that while the primary and secondary school students’ handwriting speeds differed significantly according to their grade level, gender, and handwriting style, they did not differ significantly according to their hand preferences. As the grade level increased, mean handwriting speeds also increased. Female students wrote faster than male students. Students using the manuscript handwriting style wrote faster than students who used the cursive handwriting style.
Polska pedagogika religii w kierunku badań interreligijnych i interkulturowych (zarys problematyki)
Authors: Dąbrowski Szymon
Published: January 2023

Głównym celem tekstu jest wskazanie, na ile postulaty badań interreligijnych oraz interkulturowych mogą stać się inspiracją dla polskich badań pedagogicznoreligijnych. W pierwszej części artykułu zaprezentowano naukowe nurty polskiej pedagogiki religii, następnie, w oparciu o nie, wskazano możliwe aplikacje rozwiązań interreligijnych i interkulturowych dla teorii i praktyki edukacji religijnej. Zarys powyższej problematyki umożliwić ma postawienie na nowo pytania o kształt, miejsce i rolę edukacji religijnej w zakresie edukacji ogólnej w strukturze społecznej XXI wieku w Polsce.
Afyon Kocatepe Üniversitesi enerji dağıtım hattının optimizasyon yöntemleri ile tasarlanması
Authors: YILDIZ Enes , HOCAOĞLU Fatih Onur
Published: January 2023

Elektrik enerjisi var olduğu sürece, dağıtım şebekeleri enerjinin dağıtılmasında önemli rol oynamaya devam edecektir. Gelişen ve kalkınan ülkelerde enerji talep miktarı arttıkça, enerjinin verimli kullanılmasının önemi de artmaktadır. Artan talep miktarlarıyla birlikte mevcut sistemlerin de genişletilmesi kaçınılmazdır. Bir enerji dağıtım şebekesi tasarlanırken; maksimum kalitede ve enerji aktarımının minimum maliyetlerle gerçekleştirmesi hedeflenmelidir. Çalışmada Kocatepe Üniversitesi örnek alınarak dağıtım şebekelerinin gezgin satıcı problemine uyarlanması amaçlanmıştır. Analiz için kampüs bölgesinde belirlenen bir trafo bölgesinden kampüsün dağıtım hattı haritasının en kısa yol uzunluğu belirlenmiştir. Dağıtım hatlarının uzunluklarının optimal seviyelerde ayarlanması, şebeke üzerinde meydana gelecek olan teknik kayıplarında azaltılmasını; direk, iletken, vb. gibi elektriksel malzemelerin masraflarının azaltılmasını sağlayacaktır. Çalışmada gezgin satıcı problemine yeni bir bakış açısı getirilmiştir. Her fakülte birer şehir gibi kabul edilmiştir ancak, trafodan çıkan fider sayısı birden fazla olabileceğinden dolayı gezgin satıcı problemi, amaç fonksiyonu gibi hususlara yenilik getirilmiştir. Çalışmada elde edilen yöntemin, tasarlanacak olan yeni dağıtım hatlarının planlamalarına referans olması hedeflenmiştir.
Comparison of the effectiveness of connective tissue massage and myofascial release technique in young adult women with primary dysmenorrhea
Authors: Merve Yılmaz Hüsniye , Biçki Demet , Ağar Eser
Published: January 2023

Background/Aim: Dysmenorrhea can restrict daily living activities and the overall productivity of women, thereby negatively affecting quality of life and causing absenteeism in students and loss of workdays in working women. Medical treatment is frequently used in clinics, but alternative approaches are needed when currently available treatment options are not effective. The aim of this study is to investigate and compare the acute effects of two manipulative methods, connective tissue massage (CTM) and myofascial release technique (MRT), on menstrual pain, fatigue, pain threshold, and menstrual symptoms in young adult women with primary dysmenorrhea (PD).
Methods: Forty young adults diagnosed with PD and scoring ≥4 in menstrual pain intensity according to the Visual Analog Scale (VAS) were included in the study. Menstrual pain and fatigue severity was evaluated by using VAS, pain threshold by algometer device from six unique points, and menstrual symptom severity using the Menstrual Symptom Questionnaire. Participants were randomly divided into two groups and evaluated in their first menstrual cycles. In Group 1, 10 sessions of CTM were applied between the first and second menstrual cycles, and in Group 2, a single session of MRT was applied on the most painful day of the second menstrual cycle. After the application, all participants were re-evaluated on the most painful day of their second menstrual cycles.
Results: No statistically significant difference was found between the groups in terms of age, BMI, menarche age, menstrual cycle, and menstrual bleeding duration. In both groups, a significant decrease was found in pain, fatigue, and menstrual symptom severity, and a significant increase was found in pain threshold (P=0.001). MRT was found to be more effective at improving the pain threshold at all points except the first point (1st point P=0.098, 2nd point P=0.034, 3rd point P=0.037, 4th point P=0.041, 5th point P=0.009, 6th point P=0.001).
Conclusion: It was found that CTM and MRT were effective at improving pain, fatigue, pain threshold, and menstrual symptoms in PD, and MRT was found to be more effective at increasing pain thresholds compared to CTM.
Evidencias internacionales de trabajo social en gerontología. El ámbito comunitario
Authors: Martínez Matamala Carlos
Published: January 2023

Un elemento con el cual me gustaría comenzar la presente recensión corresponde a la excelente presentación y trabajo editorial establecida para el libro Evidencias internacionales de trabajo social en gerontología. El ámbito comunitario, publicado por la Escuela Nacional de Trabajo Social de la Universidad Nacional Autónoma de México y que tuvo entre sus editores a los profesores Graciela Casas Torres y Marcelo Piña Morán, este último académico de la Escuela de Trabajo Social de la Universidad Católica del Maule. Otro dato relevante es que, si bien el título del libro remite a la gerontología vista desde el trabajo social, sus capítulos son desarrollados no solo desde esta disciplina, sino también de otras áreas afines de las ciencias sociales e incluso desde la salud, perspectiva que aparece como muy pertinente y sugerente.
Abdominal cryptorchidism with background complete dissociation between the testis and the deferent duct simulating testicular regression syndrome.
Authors:   Department of Urology and Human Reproductive Health with Pediatric Urology and Andrology Courses, Rostov State Medical University, Sizonov V.V. ,   Rostov-on-Don, Russia, Makarov A.G. ,   uroandrology Department, regional children's clinical hospital, Rostov-on-don, Russian Federation; Rostov-on-Don, Russia, Vigera V.V. ,   Department of Urology and Human Reproductive Health with Pediatric Urology and Andrology Courses, Rostov State Medical University, Rostov-on-Don, Russia
Published: January 2023

Introduction. Complete separation of the deferent duct from the epididymis with the testicle in abdominal cryptorchidism cases is an extremely rare variation of abnormal development of genitals in boys. Available sources mention just 3 clinical cases similar to our observations. The unique anatomic details of the abnormality and extreme rarity of its exposure pave the way for a failure to reveal an intra-abdominal testis, and determine the need for particular attention during diagnostic laparoscopy. Materials and methods. Two patients with non-palpable left-sided cryptorchidism underwent a diagnostic laparoscopy, which revealed an intra-abdominal testis with epididymis on testicular vessels that was completely separated from the deferent duct. The difference between the described clinical cases was in the distance between the deep inguinal ring and the crossing of testicular vessels from the retroperitoneal location to the intraperitoneal position, which was approximately 3- 4 cm in the first patient and 4-5 mm in the second one. The second difference was in the "closed" deep inguinal ring found on the left side in the first case while the second patient had a patent processus vaginalis case. In both cases an incision was made in the left inguinal area, the inguinal canal was opened, and exploration thereof revealed blind-ended deferent ducts. The testicle in both cases was brought down through the inguinal canal and attached in the scrotum. Results. No complications occurred during the early postoperative care period, the check-up examination in 6 months following the surgery revealed no signs of testis atrophy or malposition in both patients. Conclusion. In diagnostic laparoscopy for abdominal cryptorchidism, it is important to consider the possibility of complete separation of the testicle and vas deferens. Detection of the deferent duct passing through the «closed» deep inguinal ring together with hypoplastic vessels does not rule out the chances for an ipsolateral intra-abdominal testis; therefore, a careful examination of the abdominal cavity along the embryological testicular migration path is necessary.
Evaluation of the effectiveness and safety of laser enucleation of the prostate in different age groups.
Authors:   urology and andrology department of the N.I. Pirogov Russian National Research Medical University, Kotov S.V. ,   Moscow, Russia, Perov R.A. ,   urology and andrology department of the N.I. Pirogov Russian National Research Medical University; Moscow, Russia, Novikov A.A. ,   department of urology of City Clinical Hospital named after S.S. Yudin of the Moscow City Health Department; Moscow, Russia
Published: January 2023

Introduction. The influence of the age phenomenon on the outcome of the surgical treatment of benign prostate hyperplasia (BPH) research is insufficient. Considering the wide use of the more advanced laser enucleation method in the surgical treatment of BPH, there is a need to evaluate the efficiency and safety of this technique among aged patients compared to younger age groups. In this review the task was to evaluate the impact of the age phenomenon on the result of treatment, using the available scientific literature. Materials and methods. Articles were searched in three databases (Pubmed, Scopus and Web of Science) using the following request: «laser enucleation», «prostate», «elderly patients», «older patients» and «age». The unsystematic review of 7 works in English containing original data demonstrated the results of different types of enucleation among the patients with a clear stratification of groups by age for the period 2013-2022 was made. Results. Тhe absolute majority of studies do not show significant differences between the age groups regarding the preoperative IPSS, Qmax, post-void residual (PVR), however, a high frequency of chronic diseases in the older age group is noticed. In most studies, no significant differences in a number of complications according to Clavien-Dindo were found. Only in one study P. Gild et al., where large samples were researched, the frequency of blood transfusions and a number of complications ≥3b, were much higher in a group of patients over 80 y.o. and older comparing to younger-aged groups: 0 (0%), 8 (1,3%), 22 (2,7%), 14 (8,2%) for the group under 60 years old, 60-69 years old, 70-79 years old, 80 years and older, respectively (p<0,001); 2 (1,5%), 12 (1,9%), 34 (3,9%), 13 (7,1%), for these groups, respectively (p=0,02). Regarding the postoperative Qmax, despite of significant improvement of this indicator in all age groups, worse results are noticed in older patients group comparing to the results of patients in younger groups. However, the tendency to balance the marked differences with a long observation period is also noticed. Conclusions. Laser enucleation of the prostate is the effective and safe method for prostatic hyperplasia treatment for the patients of any age. However, available data about bad results after the surgical treatment among elderly patients and a higher frequency of complications show the need of the further research of this topic and evaluation of the surgical treatment at an earlier age.
Simultaneous bilateral retrograde intrarenal surgery with thulium fiber laser.
Authors:   St. Luke’s Clinical Hospital, Popov S.V. ,   Saint-Petersburg, Russia, Orlov I.N. ,   St. Luke’s Clinical Hospital; Saint-Petersburg, Russia, Topuzov T.M. ,   urology department at the St. Luke’s Clinical Hospital; Saint-Petersburg, Russia, Sytnik D.A. ,   St. Luke’s Clinical Hospital. Saint-Petersburg, Russia, Pazin I.S. ,   St. Luke’s Clinical Hospital; Saint-Petersburg, Russia, Radzhabov R.M. ,   St. Luke’s Clinical Hospital; Saint-Petersburg, Russia, Suleymanov M.M. ,   St. Luke’s Clinical Hospital; Saint-Petersburg, Russia
Published: January 2023

Introduction. Urolithiasis is a common disease and up to 15% of patients have multiple kidney stones. Retrograde intrarenal surgery (RIRS) can be used in the surgical treatment of kidney stones because this method is highly effective. Patients with multiple kidney stones often necessitate several surgeries. In this study we our own experience of bilateral RIRS to analyze its effectiveness and safety. Materials and methods. From January 2021 to February 2022 the simultaneous bilateral RIRS were performed to 11 patients (7 man and 4 woman). The maximal size of stone was 21 mm (the average size of the right kidney was 15,0 mm ± 6,0 mm and the left kidney – 11,7 mm ± 4,3 mm). Average stone density was more than 1000 HU. The mean age of the patients was 57±13 years. Bilateral retrograde intrarenal surgery was performed simultaneously by two surgeons using flexible ureteroscopes using a SuperPulsed thulium fiber laser. The following parameters were assessed: surgical intervention time; stone free rate (SFR); degree of ureteral injury according to the post-ureteroscopic lesion scale (PULS); the need for drainage of the ureter in the postoperative period, assessment of the creatinine level, glomerular filtration rate (GFR) and C-reactive protein in the postoperative period; postoperative complications according to the Clavien-Dindo classification. Results and their discussion. The average duration of the surgery was 56±11 minutes. The SFR level was 90,9 %. At the final inspection of the ureters: on the right side injury Grade 0 according to the PULS scale was recorded in 10 patients, Grade 1 – in 2 patients; on the left side Grade 0 – in 9 patients, Grade 1 – in 2 patients. The surgery was completed with the installation of ureteral catheters in 10 and 9 cases on the right and left sides, respectively. Three surgical interventions ended with the installation of ureteral stents on one side or another. The level of creatinine and C-reactive protein in the postoperative period increased on average by 10.2±5.7 μmol/l and 1.8±0.6 mg/l, respectively. The GFR decreased by 7.2 ± 2.6 ml/min. A complication was registered in 1 patient – increased body temperature on the 1st day, stopped by antibiotic therapy (Clavien-Dindo II). Conclusions. Simultaneous bilateral RIRS using single-use flexible ureteroscopes and a SuperPulsed thulium fiber laser is a safe and effective procedure for patients with bilateral nephrolithiasis.