bluuebunny/crossref_metadata_2025 huggingface dataset:
Kualitas Website atau Promosi yang Mempengaruhi Minat Beli Konsumen di Onlineshop?
Authors: Hadiantini Ratih , Samino Samino
Published: March 2023

Indonesia as a country with the fastest development in e-commerce in the world has encouraged very tight competition between entrepreneurs. So demanding online business managers to be more observant in attracting Buy Interest on e-commerce websites. Buying interest can be influenced by Website Quality and Promotion. Trubus shop which is a modern agricultural shop that has a chain of offline stores in several cities in Indonesia, to expand its market Trubus stores take the initiative to develop their market in online business through websites. This study aims to determine the Effect of Website Quality, Promotion and Purchase Interest in Trubus Online Shop. The research method used is descriptive method with a quantitative approach. The collected data is then managed and analyzed using statistical tests. Based on the results of data processing, partially the quality of the website has no effect on buying interest, whereas promotion has a positive effect on buying interest
Analisis Keputusan Investasi Terhadap Nilai Perusahaan Di Pt Sido Muncul Tbk Tahun 2013-2020
Authors: Kusumawardhani Aninditha Putri
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh price earning ratio terhadap price book value khususnya di PT Sido Muncul Tbk tahun 2013-2020. Metode yamg digunakan dalam penelitian ini adalah deskriptif dengan pendekatan kuantitatif. Populasi dan sampel dari penelitian ini adalah PT Sido Muncul Tbk suatu perusahaan yang bergerak di sektor farmasi yang tercatat saham nya di Bursa Efek Indonesia. Tujuan yang hendak dicapai dalam penelitian ini adalah untuk menganalisis bagaimana pengaruh kebijakan investasi terhadap nilai perusahaan di PT Sido Muncul Tbk tahun 2013-2020. Hasil penelitian ini dapat dijelaskan bahwa nilai Sig dari Price Earning Ratio sebesar 0,023 atau nilai 0,023 < 0,05.  Price Earning Ratio memiliki t hitung lebih besar dari t tabel atau 0,945 < 0,125. Hasil penelitian menunjukkan bahwa price earning ratio yang merupakan indikator dari keputusan investasi tidak berpengaruh terhadap price book value yang merupakan indikator dari nilai perusahaan
PENGARUH ATRIBUT PERUSAHAAN TERHADAP KETERLAMBATAN AUDIT PADA PERUSAHAAN MANUFAKTUR
Authors: Himmah Elok Faiqoh
Published: March 2023

Penelitian ini bertujuan menganalisis dan mengetahui pengaruh jenis industri dan umur perusahaan terhadap keterlambatan audit pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Fenomena yang terjadi beberapa tahun ini bahwa di Pasar Modal Indonesia terjadiketerlambatan perusahaan dalam melaporkan laporan keuangan dan laporan audit. Metode penelitian yang digunakan adalah penelitian kuantitatif dengan menggunakan analisis regresi linier berganda. Penelitian menggunakan data sekunder berupa laporan keuangan dan laporan audit perusahaan terbuka yang terdaftar di Bursa Efek Indonesia. Sampel penelitian ini sebanyak 48 perusahaan dalam dua tahun. Penelitian ini menggunakan uji asumsi klasik dengan alat bantu SPSS. Hasil penelitian menunjukkan bahwa secara parsial jenis industri dan umur perusahaan tidak berpengaruh terhadap keterlambatan audit.
PENGARUH BEBAN KERJA DAN KEPUASAN KERJA TERHADAP TURNOVER INTENTION PADA PT. PUDAK SCIENTIFIC
Authors: Priyana Indarta , Syifa Denia Nur , Rusnendar Elan
Published: March 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis seberapa besar pengaruh beban kerja dan kepuasan kerja terhadap turnover intention pada PT. Pudak Scientific baik secara parsial maupun simultan. Dalam penelitian ini jenis data yang digunakan adalah data primer dan data sekunder. Untuk metode analisis data yang digunakan penulis adalah uji validitas, uji reliabilitas, uji asumsi klasik, analisis koefisien linear berganda, analisis koefisien korelasi dan analisis koefisien determinasi. Pengujian hipotesis dilakukan melalui uji t untuk mengetahui adanya pengaruh secara parsial dan uji F untuk mengetahui adanya pengaruh secara simultan dengan menggunakan program SPSS 26 for windows. Berdasarkan hasil penelitian pada PT. Pudak Scientific bahwa secara simultan beban kerja dan kepuasan kerja berpengaruh signifikan terhadap turnover intention sebesar 67,7 %, secara parsial beban kerja memberikan pengaruh yang lebih besar terhadap turnover intention yaitu 64 % daripada kepuasan kerja yang hanya memberikan pengaruh sebesar 44,3 %.
Social Media Marketing Melalui Instagram dan Brand Image dalam Membentuk Minat Beli Produk Lokal
Authors: Aprianti Vika , Supriyadi Cecep
Published: March 2023

Penelitian ini bertujuan untuk menjelaskan gambaran persepsi responden serta menjelaskan hasil besaran pengaruh variabel Social Media Marketing dan Brand Image terhadap Minat Beli Sandal Swallow Edisi Kolaborasi. Metode penelitian yang digunakan adalah  metode deskriptif dan verifikatif dengan pendekatan kuantitatif, alat yang digunakan untuk pengumpulan data adalah kusioner yang di sebarkan kepada 100 responden dengan menggunakan teknik non probability sampling dengan purposive sampling. Hasil analisis Social Media Marketing dan Brand ImageI Terhadap Minat Beli Sandal Swallow Edisi Kolaborasi adalah 0,551 atau 55,10%, sedangkan sisanya sebesar 44,90% (100% - 55,10%) dipengaruhi variabel  lainnya yang tidak diteliti dalam penelitian ini. Hasil penelitian secara parsial menunjukkan Social Media Marketing  berpengaruh positif dan signifikan terhadap Minat Beli, dan  Brand Image berpengaruh positif dan signifikan terhadap Minat Beli. Secara simultan Social Media Marketing  dan Brand Image berpengaruh positif dan signifikan terhadap Minat Beli Sandal Swallow Edisi Kolaborasi.
Reforms in Assessment as a Key Driver of Quality Education in Somalia
Authors: Warsame Ahmed Mohamud
Published: March 2023

Assessment and evaluation are believed to significantly influence the quality of teaching and learning processes of education. The assessment determines whether teachers have delivered the exact message and students have absorbed it. On the one hand, each course has goals and objectives that students are expected to have achieved by the time they have finished. Therefore, in order for teachers to determine whether or not the goals have been achieved, they use assessments to measure the progress that their students have made. As a consequence of this, the quality of the students would be heavily dependent upon the quality of the questions tested. On the other hand, it might be difficult and time-consuming for the instructors to prepare the exam questions. Poorly designed exams, however, do not measure the intended learning outcomes; instead, they typically provide unreliable or misleading information that may lead institutions and decision-makers to make the wrong decisions. Assessment can be crucial for accountability, transparency, and education reforms. As a result, the goal of this reform study is to present a useful assessment system that will enable the achievement of the aforementioned goals. The study intends to clarify the requirements for a Somalia-specific assessment system. It will highlight crucial areas of our examination system that demand the MoE’s immediate attention. The reform will also present the best evaluation system methods from areas with Somalia-like or much related features. Reforming exams only, however, will not have a significant impact unless it is combined with other fundamental changes such as curriculum reform, school accountability, student-textbook ratios, and teacher-classroom ratios and so.
Cholangiocarcinoma: a current literature review.
Authors: Pérez Ramírez A , Ruz Zafra P , Pérez Estrada C , Sánchez Torrijos Y
Published: March 2023

El colangiocarcinoma incluye un grupo muy heterogéneo de neoplasias que pueden surgir de cualquier punto del sistema biliar. Según el punto del árbol biliar donde se originen se pueden clasificar en intrahepático, perihiliar y distal. Generalmente presentan un mal pronóstico y la mayoría se diagnostican en etapas avanzadas de la enfermedad. Su incidencia a nivel mundial es variable según la prevalencia de sus diferentes factores de riesgo así como el subtipo de colangiocarcinoma.

Para el diagnóstico existen distintas pruebas de imagen como la ecografía, ecografía con contraste, tomografía computerizada y resonancia magnética, siendo esta última la técnica gold standard en los últimos años. La biopsia representa el pilar fundamental en el diagnóstico, sin embargo, ésta no siempre es posible ni imprescindible. Para la estadificación se utiliza el sistema TNM, existiendo clasificaciones independientes para cada subtipo.

La resección quirúrgica es la única opción potencialmente curativa, sin embargo, un alto porcentaje de pacientes se diagnostica en etapas avanzadas de la enfermedad, cuando el tumor es ya irresecable y la única opción disponible es la quimioterapia paliativa. Tras la cirugía, se recomienda tratamiento quimioterápico adyuvante dado el alto riesgo de recidiva. Se encuentran en marcha ensayos clínicos de inmunoterapia, basada en el perfil genético de cada tipo de colangiocarcinoma, de los que se esperan resultados prometedores.

El trasplante hepático es una opción terapéutica que actualmente solo se considera en el subtipo perihiliar, como excepción al MELD.
Gestión del conflicto por el recurso hídrico
Authors: Silva Hernández Francisca
Published: March 2023

El agua como bien vital de todo ser vivo, ante un estado de vulnerabilidad, daño y/o riesgo puede manifestarse como conflicto socio ambiental. En el mapeo del conflicto se identifican diversos actores, sin embargo, un actor imprescindible son los miembros de la comunidad en el que emergen conflictos que deben ser gestionados para llevar a un consenso de bien común. El estudio de caso expuesto, aborda y describe elementos esenciales que deben ser previstos en la gestión y acuerdos de conflicto entre miembros de ejidos, comunidades y/o pueblos indígenas desde la interpretación del lenguaje social y cultural.
Emprendimiento indígena: generador de capital social y respetuoso del ecosistema natural
Authors: Tapia Mejía Erik
Published: March 2023

El emprendimiento es considerado una estrategia de desarrollo. Esta investigación tiene el objetivo de discutir la importancia que tienen los emprendimientos indígenas en sus localidades y la relación que encuentran estos impulsos empresariales con el crecimiento económico; para lo anterior, se utiliza un método hermenéutico con énfasis en la literatura temática sobre el emprendimiento en comunidades indígenas. Los principales resultados expresan que los emprendimientos indígenas son creadores de capital social y respetuosos del ecosistema natural y adicionan valor al integrar en sus productos y/o servicios caracteres particulares de sus culturas, teniendo sucesiva actividad en los sectores de producción primario.
nuevo medio en el arte
Authors: Ortuño Mengual Pedro
Published: March 2023

El vídeo fue considerado por Gene Youngblood (1979) como un nuevo medio de creación artística, cuyos códigos abrirán nuevas perspectivas a la imagen en movimiento dándole entidad estética propia. Se analiza diversas teorías relacionadas con la comunicación y el arte de autores como Wiener, Benjamin, Brecht, McLuhan, Burris. Así mismo estudia obras pioneras y el uso del feedback loop como elemento de retroalimentación entre emisor receptor. Wipe Cycle (1969) de Frank Gillette e Ira Schneider y Time Delay Room (1974) de Dan Graham nos mostrarán las claves para entender el funcionamiento interno de un nuevo medio que acababa de nacer.
Tolerar sin asimilar: coexistencia entre judíos y cristianos en la Castilla bajomedieval
Authors: Pérez Castaño Gonzalo
Published: March 2023

La historiografía ha revisado el falso mito de la «idílica convivencia» de las tres culturas. Para ello, ha alejado la cohabitación pacífica entre las tres religiones del imaginario colectivo medieval. Los vínculos entre la mayoría cristiana y la minoría judía sufrieron una serie de alteraciones a lo largo de la Edad Media como consecuencia de la coexistencia y de los episodios de violencia. Así pues, el objetivo de este trabajo es identificar los sustantivos y adjetivos que hacen referencia a los judíos en los discursos medievales de los siglos XIV y XV.
Revisión de los estudios de disponibilidad léxica en Bolivia, Perú, Ecuador y Venezuela
Authors: Herranz-Llácer Cristina V.
Published: March 2023

Este artículo muestra los resultados de una revisión bibliográfica sistemática sobre la disponibilidad léxica en Bolivia, Perú, Ecuador y Venezuela. Para el desarrollo adecuado de la investigación se utilizaron las plataformas Dialnet, Scielo, Google Scholar y DispoLex. Con los datos recogidos, se ha podido inferir que la producción científica en torno a esta temática es reciente. Sin embargo, esto no implica que las publicaciones puedan considerarse poco relevantes. Todo lo contrario, gracias a ellas se han propuesto planes para fomentar la lectura, el análisis del vocabulario relacionado con las nuevas tecnologías o, por ejemplo, el uso de nuevas herramientas web.
Estudo do sufixo -il no galego-português antigo
Authors: López-Viñas Xoán
Published: March 2023

Este trabalho analisa a forma, a função e o significado do sufixo -il formador de adjetivos deverbais, e por vezes desubstantivais, no galego-português medieval, com a finalidade de observar a sua produtividade na formação de vozes sufixadas, e a sua comparança com o sufixo latino -ilis de que deriva (e proveniente de diferentes origens). Para levar a cabo este estudo partimos do Corpus do Galego-Portugués Antigo, que nos permitirá verificar o grau de produtividade ou de rentabilidade deste sufixo.
Low levels of HER2 expression: new ideas for differentiated strategies in the choice of treatment for triple-negative breast cancers
Authors: Андреев Дмитрий , Завьялов Александр
Published: March 2023

Введение. Группа РМЖ с тройным негативным фенотипом (РМЖЭР–/ПР–/HER2–) неоднородна. По ранним представлениям клиницистов анти-HER2-таргетная терапия не может быть использована при РМЖЭР–/ПР–/HER2–. С клинической разработкой новых конъюгатов на основе анти-HER2–антитело-линкер-цитостатик, эксперты все чаще высказываются за необходимость пересмотра критериев оценки HER2-негативных опухолей и определения статуса «низкая экспрессия HER2» среди известных молекулярных подтипов РМЖ, включая РМЖЭР–/ПР–/HER2–.
Цель исследования. Обобщение научных данных о значении статуса «низкая экспрессия HER2» в выборе HER2-таргетной терапии пациентов с РМЖЭР–/ПР–/HER2–.
Материалы и методы. Исследование выполнено по результатам поиска в базах цифровой платформы PubMed / Medline и системы Google.
Результаты. Доля РМЖ со статусом «низкая экспрессия HER2» составляет около 50% и 35% в целом для РМЖ и для группы РМЖЭР–/ПР–/HER2–соответственно. Модернизация алгоритмов выбора терапии при РМЖ ЭР–/ПР–/HER2– обосновывается, в том числе многообещающими результатами исследований эффективности применения конъюгатов на основе анти HER2 – антител при HER2-низкоположительных опухолях. Например, по предварительным данным при метастатическом HER2-низкоположительном HR-негативном РМЖ прирост медианы выживаемости без прогрессирования по сравнению с ХТ может составить до 5,6 мес. (8,5 по сравнению с 2,9 мес.; ОР 0,46, 95% ДИ [0,24, 0,89]), а медианы общей выживаемости до 9,9 – мес. (18,2 по сравнению с 8,3; ОР 0,48, 95% ДИ [0,24, 0,95]).
Заключение. Понимание гетерогенности HER2-статуса и дальнейшая клиническая разработка критериев для назначения анти Her2-таргетных конъюгатов может привести к существенному изменению стандарта лечения по крайней мере у 1/3 всех пациентов с РМЖЭР–/ПР–/HER2–, для которых исчерпаны многие опции терапии.
Therapy for HER2-positive gastric cancer: an overview of the molecular and genetic characteristics of the signaling pathway, the results of clinical trials
Authors: Чайка Анна , Гусакова Мария , Хомяков Владимир , Рябов Андрей , Каприн Андрей
Published: March 2023

Рак желудка – это злокачественное заболевание с низкой общей выживаемостью, характеризующееся, в ряде случаев, агрессивным течением, несмотря на современные достижения хирургии, химиотерапии, молекулярно-генетических технологий. В связи с тем, что результаты лечения по-прежнему крайне неудовлетворительные, поиск новых терапевтических мишеней стал задачей номер один. В исторической перспективе HER2/neu-ориентированная таргетная терапия, продемонстрировавшая высокую эффективность в лечении рака молочной железы, послужила причиной для поиска высокого уровня экспрессии в других злокачественных новообразованиях. На протяжении десятилетий исследовались различные опухолевые локализации. Выяснено, что 10-20% аденокарцином желудка имеют высокую экспрессию HER2 рецептора. Результаты клинического исследования ToGA позволили включить трастузумаб в первую линию системной химиотерапии неоперабельного местнораспросраненного и метастатического HER2-положительного рака желудка. Настоящий обзор посвящен комплексному рассмотрению HER2-ориентированной таргетной терапии рака желудка, с раскрытием молекулярно-генетических особенностей сигнального пути, оценкой результатов существующих клинических исследований.
Overall Survival of Patients with Metastatic Esophageal Cancer: Russian Multicenter Registry Study
Authors: Тимофеев Илья , Зуков Руслан , Петкау Владислав , Гамаюнов Сергей , Плохотенко Ирина , Киселев Николай , Утяшев Игорь , Гордон Константин , Гулидов Игорь , Стаценко Галина , Владимирова Любовь
Published: March 2023

Актуальность: В 2019 г. в России было диагностировано 8.327 новых случаев рака пищевода и зарегистрировано 5.546 летальных исходов от этой опухоли. В настоящем регистровом исследовании оценивали общую выживаемость (ОВ) в реальной практике и подходы к лечению пациентов с впервые диагностированным в 2019-2020 гг. метастатическим раком пищевода.
Материалы и методы: Ретроспективно выявлены больные в 7 онкологических учреждениях (8% всех онкологических учреждений) в различных регионах России (Екатеринбург, Красноярск, Москва, Нижний Новгород, Омск, Обнинск, Ростов-на-Дону). Центры расположены в южной, центральной и восточной частях страны. Обезличенные данные были собраны исследователями в регистр, включающий демографические данные, методы и результаты лечения. Пациенты были включены, если метастатический рак пищевода был диагностирован в период с января 2019 г. по январь 2020 г. Для участия в исследовании пациенты должны были иметь гистологически подтвержденный метастатический рак пищевода и возраст ≥18 лет на момент постановки диагноза. Первичным интересующим исходом была медиана ОВ.
Результаты: 175 пациентов были включены в исследование для анализа. Среднее количество больных в одном регионе в год составило 29 человек. Все больные имели метастазы. Медиана возраста на момент постановки диагноза метастатического рака пищевода составила 63 (34-93) года (24% пациентов в возрасте ≥70 лет). Пациенты были преимущественно мужчинами (76%) с плоскоклеточным раком (69,3%). 159 (84%) и 134 (71%) пациентов не получали нео/адъювантную системную терапию или лучевую терапию соответственно. Системная химиотерапия использовалась для лечения метастатического рака у 85 (48,6%) пациентов. Наиболее часто назначаемой комбинацией был паклитаксел с цисплатином или карбоплатином (61/85, 72%). 24 (14%) пациента получили ≥2 линии лечения. Медиана ОВ составила 4,9 (95% ДИ, 3,86-5,94) месяцев. Медиана ОВ у пациентов, получавших системную терапию (11 мес; 95% ДИ 7,89–14,11), была значительно выше, чем у пациентов, не получавших терапию (2,4 мес; 95% ДИ 1,63–3,18; P<0,0001). Многофакторный регрессионный анализ Кокса показал, что на ОВ влияли наличие в анамнезе системной и лучевой терапии, а также частота ответов.
Выводы: Результаты российского регистрового исследования свидетельствуют о необходимости дальнейшего внедрения современных рекомендаций и методов в реальную клиническую практику с целью увеличения продолжительности жизни больных раком пищевода.
EFEKTIFITAS PIJAT BAYI TERHADAP PERKEMBANGAN BAYI (MOTORIK KASAR, MOTORIK HALUS, SOSIAL KEMANDIRIAN DAN BAHASA) PADA BAYI USIA 6-7 BULAN DI DESA DERMAYON KRAMATWATU
Authors: NURSEHA NURSEHA , SUBAGIYO SRI UTAMI
Published: March 2023

Pendahuluan: Pemberian  stimulus  yang  diberikan  sesaat  setelah  bayi  lahir  memberikan  efek  yang  sangat  penting  pada perkembangan kemampuan motorik dan adaptasi sosial di masa perkembangan bayi hingga dewas. Pijat bayi merupakan pengungkapan kasih sayang antara orang tua dengan anak lewat sentuhan pada kulit yang berdampak sangat luar biasa. Tujuan penelitian ini adalah untuk mengetahui efektifitas dari pijat bayi terhadap perkembangan (motoric kasar, motoric halus, social kemandirian dan Bahasa) bayi usia 6-7 bulan. Metode: Penelitian ini merupakan penelitian quasi experiment dengan rancangan non equivalen control group design. Lokasi penelitian akan dilakukan di Puskesmas Kramatwatu dan waktu penelitian dilakukan pada bulan Mei – Juli 2022. Populasi penelitian ini adalah ibu yang mempunyai bayi dengan umur 6 bulan sampai 7 bulan. Adapun teknik pengambilan sampel yang digunakan adalah total populasi. Analisis data dengan menggunakan uji t dengan tingkat kepercayaan 95% dan tingkat kemaknaan (α) 0,05. Hasil dan Pembahasan: Hasil penelitian menunjukan pijat bayi efektif terdapat perkembangan motorik kasar (0,015), Pijat bayi efektif terdapat perkembangan motorik halus (0,025), Pijat bayi efektif terdapat perkembangan sosial kemandirian (0,032), Pijat bayi efektif terdapat perkembangan bahasa (0,019). Kesimpulan: Pijat bayi terbukti efektif terhadap perkembangan motorik kasar, motorik halus, sosial kemandirian, dan bahasa pada bayi usia 6-7 bulan.
FAKTOR DETERMINAN PENGETAHUAN REMAJA TENTANG KELUARGA BERENCANA DI PROVINSI BENGKULU
Authors: FAUZI YUSRAN , SARI FIKITRI MARYA
Published: March 2023

Keluarga berencana merupakan tindakan yang membantu individu atau pasangan suami istri untuk mendapatkan objektif tertentu menghindari kelahiran yang tidak di inginkan, mengatur interval diantara kehamilan, mengontrol waktu dan kelahiran dalam hubungan suami istri dan menetukan jumlah anak dalam keluarga. Pemahaman akan kesehatan reproduksi harus dimulai sejak dini. Oleh karena itu remaja diperkenalkan tentang Keluarga Berencana sejak dini. Pengetahuan tentang kontrasepsi penting untuk remaja, karena pengetahuan ini dibutuhkan untuk pembentukan sikap remaja. Pengetahuan tentang keluarga berencana juga diperlukan untuk remaja ketika nanti membentuk keluarga baru, Pengetahuan akan kontrasepsi pada remaja bukan memberikan akses yang bebas ataupun menyediakan kontrasepsi pada remaja, namun pengetahuan ini diberikan agar menjadi pertimbangan para remaja dalam mengambil sikap dan perilaku yang positif dalam masyarakat. Penelitian ini bertujuan untuk mengetahui faktor determinan pengetahuan remaja tentang keluarga berencana di Provinsi Bengkulu dengan menggunakan data sekunder hasil Survei Kinerja dan Akuntabilitas Program Kependudukan Keluarga Berencana dan Pembangunan Keluarga Perwakilan BKKBN Provinsi Bengkulu. Jenis penelitian merupakan survei analitik dengan menggunakan rancangan cross sectional. Populasi dan sampel pada penelitian ini adalah seluruh remaja usia 10 sampai dengan 24 tahun di Provinsi Bengkulu yaitu sebanyak 845 orang remaja. Pengambilan sampel dengan menggunakan teknik systematic random sampling. Hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara jenis kelamin, umur dan pendidikan dengan pengetahuan remaja tentang keluarga berencana di Provinsi Bengkulu.
PENGARUH KODE TOPOGRAPHY DAN MORPHOLOGY TERHADAP KEAKURATAN KODE DIAGNOSA NEOPLASMA BERDASARKAN ICD-10
Authors: HARMANTO DENO , HERISANDI ARI
Published: March 2023

Pelaksanaan kodefikasi topography dan morphology pada kasus neoplasma sangat penting dilaksanakan secara tepat, dikarenakan kode topography menunjukan letak dan morphology menunjukan sifat keganasan neoplasma. Dalam penetapan kode noeplasma sering terjadi ketidaktepatan kode yang disebabkan petugas coder kurang memahami tata cara pengkodean neoplasma. Hal ini berdampak terhadap pelayanan kepada pasien seperti kesalahan tindakan, perawatan dan pengobatan. Tujuan : Penelitian ini bertujuan mengetahui gambaran ketepatan kode topography dan morphology pada diagnosa neoplasma di Rumah Sakit Raflesia Bengkulu. Metode: Jenis penelitian ini adalah deskriptif observasional melalui pengamatan secara langsung dengan populasi dan sampel 276 berkas rekam medis dengan diagnosa neoplasma. Data yang digunakan dalam penelitian ini adalah data primer dan sekunder yang diolah secara univariat.
HUBUNGAN PERILAKU HIGIENE IBU DAN KEJADIAN DIARE DENGAN KEJADIAN STUNTING PADA BALITA
Authors: KHAIRANI NURUL , EFFENDI SANTOSO UJANG , SURYANI SURYANI
Published: March 2023

Dampak stunting pada anak bersifat langsung dan jangka panjang yaitu peningkatan morbiditas dan mortalitas, gangguan perkembangan, kapasitas belajar, dan peningkatan risiko infeksi dan penyakit tidak menular. Tujuan penelitian ini adalah untuk mempelajari hubungan perilaku higiene ibu dan kejadian diare dengan kejadian stunting pada balita yang berkunjung ke Posyandu di di wilayah kerja Puskesmas Padang Serai Kota Bengkulu. Jenis penelitian adalah Survei Analitik dengan desain Case Control. Sampel kasus adalah seluruh ibu yang memiliki balita stunting yang berusia 12-59 bulan sebanyak 26 ibu. Sampel kontrol adalah  ibu yang memiliki balita tidak stunting yang berusia 12-59 bulan sebanyak 26 ibu. Teknik pengambilan untuk sampel kasus adalah Total Sampling, sedangkan untuk sampel kontrol adalah Purposive Sampling. Data dikumpulkan dengan menggunakan kuesioner dan pengukuran antropometri. Data dianalisis secara univariat dan bivariat. Analisis bivariat menggunakan uji statistik Chi-Square (χ2). Hasil penelitian menunjukkan bahwa 26 ibu (50,0%) memiliki balita yang mengalami kejadian stunting, 43 ibu (82,7%) memiliki perilaku higiene kurang baik, dan 39 ibu (75,0%) memiliki balita yang mengalami kejadian diare. Tidak ada hubungan yang signifikan antara perilaku higiene ibu (p=1,000, OR=1,310) dan kejadian diare (p=1,000, OR=0,814) dengan kejadian stunting. Diharapkan kepada petugas gizi Puskesmas untuk dapat memberikan edukasi kepada ibu balita tentang perilaku higiene yang baik dan pencegahan diare agar kejadian stunting dapat dicegah.
INNOVACIÓN TECNOLÓGICA Y EMPLEO: ANÁLISIS
Authors: Nina Josue
Published: March 2023

INNOVACIÓN TECNOLÓGICA Y EMPLEO: ANÁLISIS
Libro de autoría colectiva INOVACION EDUCATIVA INCLUSION Y ATENCION A LA DIVERSIDAD. Vol 1 Num 2
Authors: Ortega Rolando
Published: March 2023

Libro de autoría colectiva INOVACION EDUCATIVA INCLUSION Y ATENCION A LA DIVERSIDAD. Vol 1 Num 2
FACIAL NERVE PARALYSIS AND INTUSSUSCEPTION AS CLINICAL PRESENTATIONS OF LYMPHOBLASTIC LYMPHOMA: A RARE PEDIATRIC CASE REPORT
Authors: Musdalipa Musdalipa , Ridha Nadirah Rasyid , Salekede Setia Budi , Angriani Hadia
Published: March 2023

Lymphoblastic lymphoma (LBL) is a highly aggressive lymphoblast neoplasm due to the presence of clonal hematopoietic stem cell abnormalities of B or T cell origin. LBL represents 30% of pediatric non-Hodgkin's lymphomas. We report a 2-year-11-month-old boy with complaints of a lump in the abdomen and facial paralysis on the left side. weight loss of 3 kg in 3 months, frequent nausea and vomiting, and constipation. On physical examination, the face was not symmetrical on the left and right. palpable mass from the right iliac region to the left iliac, measuring 17.5 x 10 x 5 cm, immobile, rubbery consistency. There is lymphadenopathy right inguinal region et sinistra. Abdominal ultrasound without contrast showed ileocolic intussusception, with histopathological results showing malignant non-Hodgkin's lymphoma. The therapy given was chemotherapy according to the protocol for non-Hodgkin's lymphoma. Facial nerve paralysis and intussusception are rare clinical features of LBL. It is important to consider a differential diagnosis such as LBL in a patient with a lump accompanied by facial nerve paralysis and intussusception. Histopathological and immunohistochemical examination were needed.Keywords: Â Lymphoblastic Lymphoma; Facial Nerve Paralysis; Intussusception
INFLUENCE OF INTERNAL COMMUNICATION ON THE ORGANIZATIONAL CLIMATE OF A LOCAL EDUCATIONAL MANAGEMENT UNIT IN PERU
Authors: Curilla Sayuri , Morales José , Poma Wesley , Vicente-Ramos Wagner
Published: March 2023

The objective of this research is to determine the influence of internal communication on the organizational climate. The method used in this research is the deductive inferential scientific method, for which the type and level of applied and explanatory research were used respectively. The study sample was made up of women (45%) and men (65%), with an age range between 23 years and over, who were the object of study, with a total of 305 workers. The results that were obtained based on the reliability and validity of the measurement scales, where they specify that p < 0.05, that is, that 12 of the 15 hypotheses are accepted in the proposed correlation between internal communication and organizational climate factors, Among them interpersonal relationships, which generates assertiveness among workers, management styles, which implies increasing employee satisfaction, remuneration, which consists of the importance of knowing how to recognize the work of workers. Finally, the collective values, which encourages them to do a proper job and get involved. In conclusion, internal communication is essential to strengthen the organizational climate factors mentioned above. This ensures a good work environment in order to achieve improvements at the hierarchical and organizational level.
Simulations for Planning Next-generation Exoplanet Radial Velocity Surveys
Authors: Newman Patrick D , Plavchan Peter , Burt Jennifer A. , Teske Johanna , Mamajek Eric E. , Leifer Stephanie , Gaudi B. Scott , Blackwood Gary , Morgan Rhonda
Published: March 2023

Future direct imaging missions similar to the HabEx and LUVOIR mission concepts aim to catalog and characterize Earth-mass analogs around nearby stars. The exoplanet yield of these missions will be dependent on the frequency of Earth-like planets, and potentially the a priori knowledge of which stars specifically host suitable planetary systems. Ground- or space-based radial velocity surveys can potentially perform the pre-selection of targets and assist in the optimization of observation times, as opposed to an uninformed direct imaging survey. In this paper, we present our framework for simulating future radial velocity surveys of nearby stars in support of direct imaging missions. We generate lists of exposure times, observation time-series, and radial velocity time-series given a direct imaging target list. We generate simulated surveys for a proposed set of telescopes and precise radial velocity spectrographs spanning a set of plausible global-network architectures that may be considered for next-generation extremely precise radial velocity surveys. We also develop figures of merit for observation frequency and planet detection sensitivity, and compare these across architectures. From these, we draw conclusions, given our stated assumptions and caveats, to optimize the yield of future radial velocity surveys supporting direct imaging missions. We find that all of our considered surveys obtain sufficient numbers of precise observations to meet the minimum theoretical white noise detection sensitivity for Earth-mass habitable-zone planets. While our detection rates and mass-sensitivity are optimistic, we have margin to explore systematic effects due to stellar activity and correlated noise in future work.
Multi-messenger Approaches to Supermassive Black Hole Binary Detection and Parameter Estimation. II. Optimal Strategies for a Pulsar Timing Array
Authors: Liu Tingting , Cohen Tyler , McGrath Casey , Demorest Paul B. , Vigeland Sarah J.
Published: March 2023

Pulsar timing arrays (PTAs) are Galactic-scale gravitational wave (GW) detectors consisting of precisely timed pulsars distributed across the sky. Within the decade, PTAs are expected to detect nanohertz GWs emitted by close-separation supermassive black hole binaries (SMBHBs), thereby opening up the low-frequency end of the GW spectrum for science. Individual SMBHBs which power active galactic nuclei are also promising multi-messenger sources; they may be identified via theoretically predicted electromagnetic (EM) signatures and be followed up by PTAs for GW observations. In this work, we study the detection and parameter estimation prospects of a PTA which targets EM-selected SMBHBs. Adopting a simulated Galactic millisecond pulsar population, we envisage three different pulsar timing campaigns which observe three mock sources at different sky locations. We find that an all-sky PTA which times the best pulsars is an optimal and feasible approach to observe EM-selected SMBHBs and measure their source parameters to high precision (i.e., comparable to or better than conventional EM measurements). We discuss the implications of our findings in the context of future PTA experiments with the planned Deep Synoptic Array-2000 and the multi-messenger studies of SMBHBs such as the well-known binary candidate OJ 287.
BICEP/Keck. XVI. Characterizing Dust Polarization through Correlations with Neutral Hydrogen
Authors: Ade P. A. R. , Ahmed Z. , Amiri M. , Barkats D. , Thakur R. Basu , Bischoff C. A. , Beck D. , Bock J. J. , Boenish H. , Bullock E. , Buza V. , Cheshire J. R. , Clark S. E. , Connors J. , Cornelison J. , Crumrine M. , Cukierman A. , Denison E. V. , Dierickx M. , Duband L. , Eiben M. , Fatigoni S. , Filippini J. P. , Fliescher S. , Giannakopoulos C. , Goeckner-Wald N. , Goldfinger D. C. , Grayson J. , Grimes P. , Hall G. , Halal G. , Halpern M. , Hand E. , Harrison S. , Henderson S. , Hildebrandt S. R. , Hubmayr J. , Hui H. , Irwin K. D. , Kang J. , Karkare K. S. , Karpel E. , Kefeli S. , Kernasovskiy S. A. , Kovac J. M. , Kuo C. L. , Lau K. , Leitch E. M. , Lennox A. , Megerian K. G. , Minutolo L. , Moncelsi L. , Nakato Y. , Namikawa T. , Nguyen H. T. , O’Brient R. , IV R. W. Ogburn , Palladino S. , Petroff M. A. , Prouve T. , Pryke C. , Racine B. , Reintsema C. D. , Richter S. , Schillaci A. , Schwarz R. , Schmitt B. L. , Sheehy C. D. , Singari B. , Soliman A. , Germaine T. St. , Steinbach B. , Sudiwala R. V. , Teply G. P. , Thompson K. L. , Tolan J. E. , Tucker C. , Turner A. D. , Umiltà C. , Vergès C. , Vieregg A. G. , Wandui A. , Weber A. C. , Wiebe D. V. , Willmert J. , Wong C. L. , Wu W. L. K. , Yang H. , Yoon K. W. , Young E. , Yu C. , Zeng L. , Zhang C. , Zhang S. ,   BICEP/Keck Collaboration
Published: March 2023

We characterize Galactic dust filaments by correlating BICEP/Keck and Planck data with polarization templates based on neutral hydrogen (H i) observations. Dust polarization is important for both our understanding of astrophysical processes in the interstellar medium (ISM) and the search for primordial gravitational waves in the cosmic microwave background (CMB). In the diffuse ISM, H i is strongly correlated with the dust and partly organized into filaments that are aligned with the local magnetic field. We analyze the deep BICEP/Keck data at 95, 150, and 220 GHz, over the low-column-density region of sky where BICEP/Keck has set the best limits on primordial gravitational waves. We separate the H i emission into distinct velocity components and detect dust polarization correlated with the local Galactic H i but not with the H i associated with Magellanic Stream i. We present a robust, multifrequency detection of polarized dust emission correlated with the filamentary H i morphology template down to 95 GHz. For assessing its utility for foreground cleaning, we report that the Hi morphology template correlates in B modes at a ∼10%–65% level over the multipole range 20 < ℓ < 200 with the BICEP/Keck maps, which contain contributions from dust, CMB, and noise components. We measure the spectral index of the filamentary dust component spectral energy distribution to be β = 1.54 ± 0.13. We find no evidence for decorrelation in this region between the filaments and the rest of the dust field or from the inclusion of dust associated with the intermediate velocity H i. Finally, we explore the morphological parameter space in the H i-based filamentary model.
Weak-lensing Mass Bias in Merging Galaxy Clusters
Authors: Lee Wonki , Cha Sangjun , Jee M. James , Nagai Daisuke , King Lindsay , ZuHone John , Chadayammuri Urmila , Felix Sharon , Finner Kyle
Published: March 2023

Although weak lensing (WL) is a powerful method to estimate a galaxy cluster mass without any dynamical assumptions, a model bias can arise when the cluster density profile departs from the assumed model profile. In a merging system, the bias is expected to become most severe because the constituent halos undergo significant structural changes. In this study, we investigate WL mass bias in binary cluster mergers using a suite of idealized hydrodynamical simulations. Realistic WL shear catalogs are generated by matching the source galaxy properties, such as intrinsic shape dispersion, measurement noise, source densities, etc., to those from Subaru and Hubble Space Telescope observations. We find that, with the typical mass–concentration (M–c) relation and the Navarro–Frenk–White profile, the halo mass bias depends on the time since the first pericenter passage and increases with the mass of the companion cluster. The time evolution of the mass bias is similar to that of the concentration, indicating that, to first order, the mass bias is modulated by the concentration change. For a collision between two ∼1015
M
⊙ clusters, the maximum bias amounts to ∼60%. This suggests that previous WL studies may have significantly overestimated the mass of the clusters in some of the most massive mergers. Finally, we apply our results to three merger cases: A2034, MACS J1752.0 + 4440, and ZwCl 1856.8 + 6616, and report their mass biases at the observed epoch, as well as their pre-merger masses, utilizing their merger shock locations as tracers of the merger phases.
Classification of BATSE, Swift, and Fermi Gamma-Ray Bursts from Prompt Emission Alone
Authors: Steinhardt Charles L. , Mann William J. , Rusakov Vadim , Jespersen Christian K.
Published: March 2023

Although it is generally assumed that there are two dominant classes of gamma-ray bursts (GRBs) with different typical durations, it has been difficult to classify GRBs unambiguously as short or long from summary properties such as duration, spectral hardness, and spectral lag. Recent work used t-distributed stochastic neighborhood embedding (t-SNE), a machine-learning algorithm for dimensionality reduction, to classify all Swift GRBs as short or long. Here, the method is expanded, using two algorithms, t-SNE and UMAP, to produce embeddings that are used to provide a classification for 1911 BATSE bursts, 1321 Swift bursts, and 2294 Fermi bursts for which both spectra and metadata are available. Although the embeddings appear to produce a clear separation of each catalog into short and long bursts, a resampling-based approach is used to show that a small fraction of bursts cannot be robustly classified. Further, three of the 304 bursts observed by both Swift and Fermi have robust but conflicting classifications. A likely interpretation is that in addition to the two predominant classes of GRBs, there are additional, uncommon types of bursts which may require multiwavelength observations in order to separate them from more typical short and long GRBs.
A Systematic Magnetic Polarity Inversion Line Data Set from SDO/HMI Magnetograms
Authors: Ji Anli , Cai Xumin , Khasayeva Nigar , Georgoulis Manolis K. , Martens Petrus C. , Angryk Rafal A. , Aydin Berkay
Published: March 2023

Magnetic polarity inversion lines (PILs) detected in solar active regions have long been recognized as arguably the most essential feature for triggering instabilities such as flares and eruptive events (i.e., eruptive flares and coronal mass ejections). In recent years, efforts have been focused on using features engineered from PILs for solar eruption prediction. However, PIL rasters and metadata are often generated as by-products and are not accessible for public use, which limits their utilization in data-intensive space weather analytics applications. We introduce a large-scale publicly available PIL data set covering practically the entire solar cycle 24 for applying to various space weather forecasting and analytics tasks. The data set is created using both radial magnetic field (B_r) and line-of-sight (B_LoS) magnetograms from the Solar Dynamics Observatory’s Helioseismic and Magnetic Imager Active Region Patches (HARP) that involve 4090 HARP series ranging from 2010 May to 2019 March. This data set includes three PIL-related binary masks of rasters: the actual PILs as per the spatial analysis of the magnetograms, the region of polarity inversion, and the convex hull of PILs, along with time-series-structured metadata extracted from these masks. We also provide a preliminary exploratory analysis of selected features aiming to correlate time series of feature metadata and eruptive activity originating from active regions. We envision that this comprehensive PIL data set will complement existing data sets used for space weather forecasting and benefit research in related areas, specifically in better understanding the PIL structure, evolution, and role in eruptions.
Young Stellar Objects, Accretion Disks, and Their Variability with Rubin Observatory LSST
Authors: Bonito R. , Venuti L. , Ustamujic S. , Yoachim P. , Street R. A. , Prisinzano L. , Hartigan P. , Guarcello M. G. , Stassun K. G. , Giannini T. , Feigelson E. D. , Caratti o Garatti A. , Orlando S. , Clarkson W. I. , McGehee P. , Bellm E. C. , Gizis J. E.
Published: March 2023

Vera C. Rubin Observatory, through the Legacy Survey of Space and Time (LSST), will allow us to derive a panchromatic view of variability in young stellar objects (YSOs) across all relevant timescales. Indeed, both short-term variability (on timescales of hours to days) and long-term variability (months to years), predominantly driven by the dynamics of accretion processes in disk-hosting YSOs, can be explored by taking advantage of the multiband filters option available in Rubin LSST, in particular the u, g, r, i filters that enable us to discriminate between photospheric stellar properties and accretion signatures. The homogeneity and depth of sky coverage that will be achieved with LSST will provide us with a unique opportunity to characterize the time evolution of disk accretion as a function of age and varying environmental conditions (e.g., field crowdedness, massive neighbors, metallicity) by targeting different star-forming regions. In this contribution to the Rubin LSST Survey Strategy Optimization Focus Issue, we discuss how implementing a dense observing cadence to explore short-term variability in YSOs represents a key complementary effort to the Wide–Fast–Deep observing mode that will be used to survey the sky over the full duration of the main survey (≈10 yr). The combination of these two modes will be vital to investigate the connection between the inner-disk dynamics and longer-term eruptive variability behaviors, such as those observed on EX Lupi–type objects.
The dominance of non-indigenous species in the catch composition of small-scale fisheries: A case study from the Kaş–Kekova Special Environmental Protection Area, Türkiye, Eastern Mediterranean
Authors: Öndes Fikret , Ünal Vahdet
Published: March 2023

This study aimed to determine the catch composition and compare the catch per unit effort (CPUE) of indigenous and non-indigenous species in longline and trammel net fisheries in the Mediterranean coasts of Türkiye. The data were collected weekly from May 2020 to September 2021 by commercial fishing vessels (n = 62 days for trammel nets, n = 75 days for longlines). The results of the study indicated that more than 90% of the catch composition consisted of non-indigenous species in trammel net fishery and Pterois miles (Bennett, 1828), Siganus rivulatus Forsskål et Niebuhr, 1775, Siganus luridus (Rüppell, 1829), and Scarus ghobban Forsskål, 1775 were the most commonly caught species. Although indigenous species were more common in longlines compared with trammel nets, non-indigenous species Lagocephalus sceleratus (Gmelin, 1789) and Lagocephalus suezensis Clark et Gohar, 1953 were represented by relatively high catch ratios. The results also revealed that the CPUE of non-indigenous species exhibited seasonal differences. Although some non-indigenous species caught within this study have a market value, some other highly invasive species do not. Therefore, it is critically important to develop effective management tools to control bio-invasion. This study provides the first comprehensive research by utilizing basic data with relatively long-term surveys in the small-scale fishery on the Mediterranean coasts of Türkiye. The outcomes of this study can provide guidance to decision-makers.
The year in cardiovascular medicine 2022: the top 10 papers in valvular heart disease
Authors: Baumgartner Helmut , Iung Bernard , Messika-Zeitoun David
Published: March 2023

The year in cardiovascular medicine 2022: the top 10 papers in valvular heart disease
Calculation of the cost of enriched uranium products in multi-stream cascades of enrichment process
Authors: Semenov Evgeny V. , Kharitonov Vladimir V.
Published: March 2023

Modern uranium enrichment facilities can simultaneously use several raw materials as feed, including natural uranium, regenerated uranium obtained as a result of SNF reprocessing, or depleted uranium (all in the form of uranium hexafluoride). As the output of the separating cascade, several types of enriched uranium product with different levels of enrichment can be fabricated simultaneously. The paper proposes a methodology, absent in literature, for calculating the cost of each enriched uranium product in multi-stream separating cascades. The proposed methodology uses standard definitions of the isotopic value of feed and product stream and the Peierls-Dirac separation potential. Numerical calculations of the cost of enriched uranium products for three production problems are provided as examples of the methodology effectiveness: 1) involvement of depleted uranium hexafluoride (DUHF) in fabrication of enriched uranium product; 2) simultaneous fabrication of two enriched products; 3) use of depleted uranium to reduce the cost of the product with a higher enrichment level out of two (as applied, e.g., to advanced tolerant fuel). It has been shown that partial additions of DUHF as feed for a multi-product separating cascade make it possible to reduce the cost of a product with a higher level of enrichment; with the current market prices for natural uranium and separative work, there is a range of tails assays in which it is more profitable to enrich DUHF rather than natural uranium.
La transmodalisation, un levier pour une inclusion efficiente des élèves allophones ?
Authors: Prévost Julie
Published: March 2023

L’article interroge la transmodalisation et ses effets pour les élèves allophones inclus ou à inclure en cours de français disciplinaire, à partir d’une fonction expériencielle double : en tant que professeure de lettres modernes, d’une part, en tant que professeure de français langue seconde et scolaire (FLS/FLSco) dans une unité pédagogique pour élèves allophones nouvèlement arrivés (UPE2A) de collège, d’autre part. L’étude analyse plusieurs des contraintes effectives qui agissent sur les démarches didactiques intégrant la transmodalisation. Il en ressort que cette transmodalisation constitue l’un des leviers pour une accessibilité au sens et, conséquemment, une inclusion efficiente dans le cadre d’enseignements ordinaires.