bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic form of Pisa syndrome after prolonged exposure to low-dose amisulpride treatment
Authors: Erdem Nazan Şimşek , Özkaynak Sehur Sibel
Published: September 2021

Pisa syndrome is a movement problem defined by tonic, sustained lateral flexion with a slight posterior rotation of the trunk. It seems to be a side effect of antipsychotic medicine in most cases. The clinical duration of Pisa syndrome can be acute, chronic, or recurrent. As far as we know, no reports are available in the literature on the chronic form of Pisa syndrome caused by low-dose amisulpride. A case of refractory tardive dystonia form of Pisa syndrome during treatment with stable low-dose amisulpride is presented in this report. Long-term, low-dosage amisulpride therapy may induce tardive dystonia even in patients with no other risk factors for dystonia.
Antibiotic resistance in aerobic bacterial isolates from infected diabetic foot ulcers in North Eastern Tanzania: an urgent call to establish a hospital antimicrobial stewardship committee
Authors: Shabhay Ahmed , Horumpende Pius , Mujuni Martin , Munisi Edna Joy , Mshana Stephen , Shabhay Zarina , Mganga Andrew , Chilonga Kondo , Msuya David , Chilongola Jaffu O. , Baal Jeff Van , Chugulu Samwel
Published: September 2021

Background: Diabetic foot ulcers (DFU) is among major health problems which impact the socio economic burden globally. We aimed at assessing the susceptibility pattern of antimicrobials in DFU infections among patients admitted in the surgical department at Kilimanjaro Christian Medical Centre (KCMC).Methods: This descriptive cross-sectional study was conducted from September 2018 through March 2019. Pus swabs were collected on the first day of admission by deep wound swabbing after irrigation with normal saline solution. Kirby-Bauer method was done according to the Clinical and Laboratory Standard Institute (CLSI) guidelines.Results: Sixty diabetic ulcer patients had 62 bacterial isolates. Majority of the isolates were gram negative 49/62 (79.03%). The most common isolate was Escherichia coli 15/62 (24.19%) followed by Pseudomonas aeruginosa 14/62 (22.58%), Proteus mirabilis 8/62 (12.9%) and Staphylococcus aureus 5/62 (8.06%). Klebsiella pneumoniae, coagulase negative Staphylococcus, Proteus vulgaris, and Streptococcus pyogenes each contributed 4/62 (6.25%) isolates. Of the 49/62 (79.3%) gram negative isolates, 8/49 (16.33%) were mono resistant, 30/49 (61.22%) were multiresistant, and 11/49 (22.45%) were susceptible. Of the multi-resistant isolates, E. coli 12/15 (80.00%), and P. aeruginosa 7/14 (50.00%) were predominant. A total of 39/62 (62.90%) isolates in patients contributed to poorer outcomes including loss of body part. Patients with ulcers infected by P. aeruginosa 11/39 (28.21%) had the highest number of surgical removal of body parts followed by E. coli 8/39 (20.51%). Gram negative bacteria were highly susceptible to amikacin 91.18%, meropenem 93.33% and imipenem 95.24%. Isolates susceptibility to ceftriaxone was 32%.Conclusions: Amikacin, meropenem and imipenem can be safely used as broad-spectrum antimicrobials in DFU. The standard of care remains culture and sensitivity of isolated microorganisms in combating diabetic foot ulcers infections.
Assessment of safety and efficacy of a dietary supplement KaraLiv™ in supporting liver health: a double-blind, parallel, placebo-controlled randomized clinical trial
Authors: Rajendran Krishna , Ramaswamy Rajendran , Venkateshwarlu Kudiganti , Rajendran Ravikumar , Naik K. Sunil
Published: September 2021

Background: The liver is responsible for many critical functions within the body. If the liver becomes diseased or injured, loss of those critical functions can cause significant damage to the body. KaraLivTM is a novel herbal formulation which contains a blend of different herbal extract ingredients. The current study tested the safety and efficacy of KaraLivTM versus a placebo control in supporting liver function.Methods: The study is a randomized, double-blind, parallel, and placebo-controlled study. A total of 60 patients were divided into 2 groups of 30 each. One group was given KaraLivTM and the other group was given a placebo for a period of 56 days. Treatment results were assessed by evaluating the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and alkaline phosphatase (ALP) in both groups.Results: The herbal supplement KaraLivTM significantly supported healthy liver function compared to the placebo following the 56 days of treatment. The treatment (KaraLivTM) group showed a statistically significant improvement in assessed liver enzyme levels compared to the placebo group.Conclusions: The all-natural herbal supplement KaraLivTM is a safe and effective product that can significantly help support healthy liver function.
Online learning during COVID-19 pandemic - a cross sectional survey of students’ perception
Authors: Rani Vemuri V.
Published: September 2021

Background: The corona virus pandemic had an impact on the student’s education especially the medical and dental students. There was no option but to continue the education by using the online platforms to take lectures. This survey aims at finding out the students’ perception towards these online classes.Methods: After ethics committee approval, a pre-validated questionnaire was administered as a Google form to the first, second bachelor of medicine and bachelor of surgery (MBBS) students and first, second bachelor of dental surgery (BDS) students, data was analyzed using descriptive statistics in Microsoft excel.Results: Out of 400 students who were sent the questionnaire 169 answered, with a response rate of 42.25%. 43 (25.44%) students had responded that the availability of the PowerPoint presentation for future reference makes it better for their study. 59 (34.91%) students said the main problem with the online lectures was Internet connectivity and technical issues /buffering during the class. Mean was 3 and above for three questions regarding the interaction during online classes and missing face to face interaction with both faculty and students.Conclusions: There is a positive attitude towards online learning, but the students miss the face-to-face interaction with the faculty and students. There is a necessity for improving the required infrastructure as well as training the faculty for the use of online platforms for planning and undertaking the sessions in an interactive way keeping in view the future occurrence of similar situations.
A study on quality of life among thalassemic children aged 8 to 18 years
Authors: Jajhara Indersain , Choudhary Ganesh , Singh Jagdish , Chachan Vikal , Kumar Anil
Published: September 2021

Background: The assessment of quality of life in children, especially in those with chronic illness such as thalassaemia, is particularly important. It differs from other forms of medical assessment in that it focuses on the individuals’ own views of their well-being and other aspects of life, giving a more holistic view of well-being.Methods: Hospital based descriptive, observational study was conducted on 200 school-age children. Two tools were used to collect the necessary data. The first was a structured interview questionnaire sheet including socio-demographic data of children and their parents as well as medical history. The second tool was a standardized tool (Pediatric Quality of Life Inventory TM Version 4.0).Results: The results of the present study revealed that the quality of life of school-age children with Thalassemia Major was affected. According to child’s report regarding total QOL score 30% of children had good score compared to 35% in parent’s report, while 65% had fair score compared to 60% in parent’s report. Emotional functioning scored the lowest followed by physical then school and social functioning. Regarding compliance with treatment, 91% of the studied children had regular blood transfusion therapy. In addition, 81% of the studied children were compliant with iron chelation therapy.Conclusions: Thalassemia has a negative impact on perceived physical, emotional, social and school functioning in thalassemia patients. There was a significant association between the total quality of life and compliance with blood transfusion and regular iron chelation therapy in both child and parent report.
Proportion of ophthalmia neonatorum following prophylaxis with azithromycin eye ointment in newborns at a tertiary care centre in Central Kerala
Authors: Mammooty Najeeba Chamban , George Madhu , Joseph Jino , Tawab Abdul
Published: September 2021

Background: The objective was to evaluate the proportion of ophthalmia neonatorum among 425 hospital born newborns who had received antibiotic eye prophylaxis within one hour of birth at a tertiary care centre in Central Kerala and to detect their causative organisms.Methods: The study design was an observational study done for a period of 10 months. A total of 425 term well newborn babies were included in the study. At delivery after the normal routine newborn care, babies were received azithromycin 1% eye ointment as prophylaxis for neonatal conjunctivitis in both eyes within one hour of birth. Babies were observed routinely during every vital monitoring for developing signs of neonatal conjunctivitis for the first 72 hours of life at hospital. During outpatient follow ups, 7 to 14 days and 14 to 28 days, these babies were examined for the presence of neonatal conjunctivitis. Babies having neonatal conjunctivitis were treated empirically with the same topical 1% azithromycin eye ointment after taking eye swab for culture and sensitivity in both eyes. The treatment has been modified based on the culture reports. Proportions were compared using Chi-square test with significance at p<0.05.Results: A total 15 (3.5%) of the 425 babies developed ophthalmia neonatorum. The most common isolate was Staphylococcus aureus which was 4 (26.7%) of all positive cultures followed by Escherichia coli 13.3%, Klebsiella pneumoniae 6.7%, Serracia marcescens 6.7%. None of the risk factors were found to be having association with conjunctivitis.Conclusions: This study concludes that a high proportion of neonatal conjunctivitis present despite eye antibiotic prophylaxis, though a greater reduction in cases has been shown when compared with no prophylaxis at our centre during the previous year. S. aureus was the most common causative organism isolated.
A rare case of proximal short limb dwarfism-rhizomelic chondrodysplasia punctata type-2
Authors: Sanjana Puppala , . Triveni , . Bushra , Boyeni Vijaya Prasanna
Published: September 2021

Rhizomelic chondrodysplasia punctata (RCDP) is one of the rare peroxisomal disorder (autosomal recessive inheritance) due to altered phytanic acid alpha oxidation and plasmalogen synthesis. RCDP 1 is the most frequent form of RCDP. It is a peroxisomal biosynthesis disorder. RCDP 2 and RCDP 3 are disorders of individual peroxisome enzyme. Authors described a case of RCDP type 2 in a 13 months old girl with characteristic features of typical chondrodysplastic facies, bilateral cataract, rhizomelic shortening of limbs, growth and global developmental delay; radiological features showed epiphyseal stippling. Genetic analysis showed apparent homozygous deletion of c.1848delC after full sequencing of her GNPAT genes.
Comparative evaluation of fine detail reproduction of six different die materials- An in-Vitro study
Authors: Mukhopadhyay Pronoy , Wankhade Sattyam , Wankhade Jyoti , Khalikar Arun
Published: September 2021

The precise outcome of any indirect casting, depends on the various procedures and materials involved through all its stages. The accurate fit against the prepared surface and the adaptation against the prepared margin depends on how accurately the tooth surface is captured in the impression made and how well it is reproduced in the die

This study aims to study and compare the property of fine detail reproduction amongst six die materials.

Over a pre-calibrated master die using custom tray, an impression record is made and poured using the six different die materials and the finest line reproduced is visualized under an optical fluorescent microscope at 50X magnification.

The data obtained were statistically analysed using one-way ANOVA and subsequently assessed by post-hoc Tukey’s comparison to identify any significant differences between the groups.

Epoxy resin die material (1.93 mm) showed a consistently excellent fine detail reproduction, followed by conventional Type V gypsum and Synthetic gypsum (15.91 mm), while Resin modified-Type IV and Type V and conventional Type IV gypsum dies (21.86mm) showed the least accuracy in fine reproduction.
Papillon-lefevere syndrome-Consanguity as a risk factor in siblings (Case series)
Authors: Dubey Jaya , Parikh Shilpa J , Shah Jigna S
Published: September 2021

Papillon-Lefevere syndrome is a very rare autosomal recessive trait characterized by palmoplantar hyperkeratosis and severe generalized early-onset periodontitis leading to premature loss of primary and permanent dentitions. Various etiopathogenesis factors are associated with syndrome. The palmoplantar keratoderma typically has its onset between the ages of 1 and 4 years and severe periodontitis starts at age of 3-4 years. A dentist plays an important role in early diagnosing and preserving remaining teeth in oral cavity. This case series describes three cases of PLS in siblings with consanguineously married parents. All siblings in the family were affected which makes this a rare case.
Study on the inflammatory response in the contralateral eye after phacoemulsification combined with intraocular lens implantation in the first eye
Authors:   Department of Ophthalmology, Affiliated East Hospital of Tongji University, Shanghai 200120, China, Fang Lei , Tang Jian-Cen ,   Department of Ophthalmology, Affiliated East Hospital of Tongji University, Shanghai 200120, China, Chu Hao ,   Department of Ophthalmology, Affiliated East Hospital of Tongji University, Shanghai 200120, China, Xu Ji ,   Department of Ophthalmology, Affiliated East Hospital of Tongji University, Shanghai 200120, China, Wang Yi-Ran ,   Department of Ophthalmology, Affiliated East Hospital of Tongji University, Shanghai 200120, China, Cui Hong-Ping ,   Department of Ophthalmology, Affiliated East Hospital of Tongji University, Shanghai 200120, China
Published: September 2021

AIM: To explore whether there is an inflammatory response in the contralateral eye after cataract surgery in the first eye, and try to explore the development of the inflammatory response.
METHODS: In this paired-sample study, aqueous humor samples from 37 bilateral age-related cataract patients were collected just before each cataract surgery. Samples collected during the first-eye cataract surgery were marked as Group A, samples collected during the second-eye cataract surgery were marked as Group B. In addition, the samples were classified into five groups according to different operation intervals between the first and the second cataract surgery. Finally, the concentration of 13 selected cytokines (including TNF-α, IL-6, IL-8, CCL2/MCP-1, IL-6 Rα, IL-1 ra, MIP-1α, MIP-1d, CCL4, IL-2, CXCL9, TIMP-1, CCL11) in aqueous humor samples was detected by Luminex-200 (RnD) simultaneously in accordance with the manufacturer’s instructions.
RESULTS: Among the 13 selected cytokines, there was statistically difference between the first and the second eyes in concentration of IL-6, MIP-1α, CCL2/MCP-1, TNF-α, MIP-1d, IL-2 and TIMP-1 (P<0.05), and the expression levels of all these seven cytokines in the second eyes were higher than those in the first eyes, and the concentration of IL-6 and MIP-1a in the second eyes was significantly higher than that in the first eyes (P<0.001). Compared with the first eyes, the concentration of CCL4, CCL11, IL-6Rα, CXCL9, and IL-1ra in the second eyes only showed slightly increase, while IL-8 showed a slight decrease, all with no statistically difference (all P>0.05). The concentration differences of IL-6, MCP-1/CCL2, IL-2, MIP-1d between the first eyes and the second eyes were most obvious at the third week after phacoemulsification combined with intraocular lens implantation (PHACO+IOL) in the first eye.
CONCLUSION: This study revealed that there may be an inflammatory response in the contralateral eye after cataract surgery in the first eye, and the inflammatory response in the second eye appears to be most significant at the third week after phacoemulsification combined with intraocular lens implantation (PHACO+IOL) in the first eye.
Hypertension and diabetes synergistically strengthen the association with cataracts among Chinese
Authors:   Department of Ophthalmology, People’s Hospital of Fuyang City, Fuyang 236000, Anhui Province, China, Li Jin-Jin , Li Jie ,   Department of Ophthalmology, People’s Hospital of Fuyang City, Fuyang 236000, Anhui Province, China, Yang Xiao ,   Department of Ophthalmology, People’s Hospital of Fuyang City, Fuyang 236000, Anhui Province, China, Xia Dan ,   Department of Ophthalmology, People’s Hospital of Fuyang City, Fuyang 236000, Anhui Province, China, Li Yu ,   Department of Ophthalmology, People’s Hospital of Fuyang City, Fuyang 236000, Anhui Province, China, Wang Wei ,   Department of Social Medicine, School of Public Health, Fudan University, Shanghai 200433, China, Yan Fei ,   Department of Social Medicine, School of Public Health, Fudan University, Shanghai 200433, China, Zhang Jian ,   Department of Epidemiology, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro 30460, GA, USA
Published: September 2021

AIM: To examine the relationship between age-related cataracts (ARC) and comorbid hypertension and diabetes.
METHODS: We analyzed the administrative records of 6,467 patients aged 50 years and older admitted to the ophthalmological department of a tertiary hospital from January 1st, 2011 to May 20th, 2017. With either eye considered, an ARC (n=3,343) was defined as the presence of lens opacity or previous cataract surgery without evidence of trauma, congenital anomalies or using certain medications. Patients admitted to the same department during the same period due to ocular traumas without clinical evidence of cataracts (n=379) were recruited as the cataract-free controls. Unconditional logistic regressions were obtained the odds ratio (OR) of hypertension and diabetes among ARC patients adjusted for age, sex and health care accessibility.
RESULTS: Hypertension was diagnosed in 29.54% of men with any type of cataracts, in 30.12% of men with an ARC, and 10.82% of men of cataract-free controls. Diabetes was diagnosed in 16.64% of men with any type of cataracts, in 16.48% of men with ARC and 4.22% of men of cataract-free controls. Similar patterns were observed among women. After adjusting for age, sex, and health care accessibility, hypertension was weakly [OR=1.83 (95%CI: 1.23, 2.74)] and diabetes was strongly [3.38 (1.86, 6.15)] associated with ARCs. The adjusted OR of comorbid hypertension and diabetes among adults with ARC was 18.20 (4.38, 75.59).
CONCLUSION: Hypertension and diabetes were independently associated with ARC. Hypertension and diabetes, if co-existing, multiplicatively strengthened the association with ARC.
Review on superglue eye injuries
Authors:   Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran 1336616351, Iran, Torkashvand Ali , Abdi Fatemeh ,   Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran, Soleimani Mohammad ,   Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran 1336616351, Iran
Published: September 2021

The purpose of this study is to run a review on possible superglue injuries to the eye. In this review, previous papers regarding the harmful impacts of superglue were systematically studied. Superglue eye injuries have been common during the three last decades and most of them were accidental and preventable by introducing safety issues and although it may be toxic for the tissues, it is not associated with long term morbidity. This paper addresses the management of superglue injuries and shows the importance of the prevention of ocular superglue injuries.
Interactions of thymic stromal lymphopoietin with interleukin-4 in adaptive immunity during Aspergillus fumigatus keratitis
Authors:   Department of Ophthalmology, Clinical Medical College of Shandong University, Jinan 250012, Shandong Province, China; Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China, Chen Chen , Han Fang ,   Department of Ophthalmology, Clinical Medical College of Shandong University, Jinan 250012, Shandong Province, China; Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Shandong University, Jinan 250012, Shandong Province, China, Wu Jia-Yin ,   Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China, Sun Lin ,   Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China, Wu Xin-Yi ,   Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Published: September 2021

AIM: To investigate the potential interactions of thymic stromal lymphopoietin (TSLP) with interleukin-4 (IL-4) in adaptive immunity during fungal keratitis (FK).
METHODS: An FK mouse model was induced with Aspergillus fumigatus (AF) hyphal infection. Mice were divided into several groups: untreated, phosphate buffer saline (PBS), infected with AF, and pretreated with a scrambled siRNA, a TSLP-specific siRNA (TSLP siRNA), murine recombinant TSLP (rTSLP), immunoglobulin G (IgG), murine recombinant IFN (rIFN-γ), murine recombinant IL-4 (rIL-4), rIL-13, murine recombinant IL-17A (rIL-17A), and murine recombinant IL-17F (rIL-17F) groups. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) or Western blot were performed to determine mRNA and protein levels in the inflamed cornea. Cytokine locations were observed by immunofluoresence staining after AF hyphal infection.
RESULTS: Compared to those in the untreated group, TSLP and T helper type 1 (Th1) cytokine levels in the AF group were upregulated at 24h post infection (hpi), and those of T helper type 2 (Th2) and T helper type 17 (Th17) cytokines were increased at 5d post infection (dpi). Th2 cytokine levels were decreased in the TSLP siRNA-pretreated group and increased in the rTSLP-pretreated group compared with the AF group. The TSLP level was increased in the rIL-4-pretreated group, but there were no significant changes among the other groups. Immunofluorescence staining showed cytokine locations after AF hyphal infection.
CONCLUSION: TSLP induces a Th2 immune response and promots Th2 T cell differentiation in vivo. IL-4 promotes TSLP secretion. Therefore, TSLP with IL-4 regulates adaptive immunity in FK.
Clinical effectiveness of diquafosol ophthalmic solution 3% in Korean patients with dry eye disease: a multicenter prospective observational study
Authors:   Department of Ophthalmology, Korea University College of Medicine, Seoul 02841, Republic of Korea; Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do 15355, Republic of Korea, Eom Youngsub
Published: September 2021

AIM: To investigate the effectiveness of diquafosol ophthalmic solution 3% administered in Korean patients with dry eye disease in real-world clinical settings.
METHODS: Diquafosol was administered for 8wk to 3 patient groups who received diquafosol as add-on therapy to existing medication (Add group, n=150); received diquafosol only (Monotherapy group, n=196); or discontinued part of their existing medication in favor of diquafosol (Switch group, n=11). Tear break-up time (TBUT), cornea and conjunctival staining based on National Eye Institute/Industry scoring scheme, subjective symptoms using the Ocular Surface Disease Index (OSDI) questionnaire, and meibum quality and expressibility were evaluated at baseline, week 4, and week 8.
RESULTS: The mean TBUT increased (from 3.46, 3.92, and 5.84s, respectively, to 5.15, 5.53, and 8.59s, respectively) and corneal staining score decreased (from 2.23, 2.24, and 3.09, respectively, to 0.85, 0.97, and 1.64, respectively) in a time-dependent manner from baseline to week 8 in all three groups. Conjunctival staining score, OSDI questionnaire, and meibum quality and expressibility improved over time from baseline to week 8 in the Add and Monotherapy groups, but differences were not statistically significant in the Switch group.
CONCLUSION: Diquafosol improves subjective symptoms and objective signs in patients treated with existing medicines combined with diquafosol and treated solely with diquafosol. Diquafosol can be used as an effective therapeutic agent for dry eye disease or additionally applied in patients who have insufficient response to existing medicines.
Visual acuity after intravitreal ranibizumab with and without laser therapy in the treatment of macular edema due to branch retinal vein occlusion: a 12-month retrospective analysis
Authors:   Department of Ophthalmology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo 136-0075, Japan, Umeya Reiko , Kasuga Toshimitsu ,   Department of Ophthalmology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
Published: September 2021

AIM: To identify factors contributing to visual improvement after treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO), and to assess the interaction between laser therapy and intravitreal ranibizumab (IVR).
METHODS: We retrospectively reviewed the medical records of patients who had been treated for BRVO-related ME at our hospital. Records were traceable for at least 12mo, and evaluated factors included age, sex, medical history, smoking history, treatment methods, foveal hemorrhage, and change in visual acuity. Treatments included laser therapy, IVR, sub-Tenon’s capsule injection of triamcinolone (STTA), a combination, or no intervention. Multivariate logistic regression analysis and interaction terms were used to assess the clinical efficacy of the treatments, and odds ratios (OR) and 95% confidence intervals (CI) were calculated.
RESULTS: Seventy-three patients (34 men, 39 women; 73 eyes) with a mean age of 69.4±12.1y were included. Patients who underwent IVR monotherapy, laser monotherapy, and STTA+laser had significantly higher best corrected visual acuity at 12mo compared to baseline (P<0.001, <0.001, and 0.019, respectively). Logistic regression analysis without interaction terms found that IVR was a significant visual acuity recovery factor (adjusted OR: 3.89, 95%CI: 1.25-12.1, P=0.019). Adjusted OR using an interaction model by logistic regression was 16.6 (95%CI: 2.54-108.47, P=0.003) with IVR treatment, and 8.25 (95%CI: 1.34-50.57, P=0.023) with laser treatment. No interaction was observed (adjusted OR: 0.07, 95%CI: 0.01-0.75, P=0.029).
CONCLUSION: IVR contributes to improvements in visual acuity at 12mo in ME secondary to BRVO. No interaction is observed between laser therapy and IVR treatments.
Precarization of employment relationships in remote–working conditions during COVID-quarantine
Authors: Eremicheva Galina V.
Published: September 2021

The large-scale social consequences of the global COVID epidemic demanded a multilateral analysis of its impact on the global processes of social development of the country. Particularly noticeable changes are observed in the sphere of work and labor relations. More than a years self-isolation and quarantine conditions necessitated the introduction of a remote work mode, accelerated the pace of mastering digital technologies in almost all areas of employment, and determined new requirements for the specialized qualities and competencies of workers. The massive transition to remote work turned out to be a professional challenge for many workers with different social status and required the ability to get involved in the digital economy in a dynamically short time frame. Employees who were unable to adapt to new conditions lost their jobs. Despite the positive aspects of working remotely, a number of negative aspects have been identified that seriously affected everyday life in a pandemic reality. Among them the most tangible are: the growing uncertainty and opacity of the labor and wages legal forms, individualization of workers, which deepen the process of labor relations precarization. The conclusions were made in accordance with the results of the analysis of entrepreneurs and public sector employees pilot interviews under conditions of quarantine restrictions, the analysis of materials from official statistics, monitoring data from analytical centers of Russian Public Opinion Research Center, Public Opinion Foundation, National Agency for Financial Studies and others.
The Hiddenness Argument and the Ground of Its Soundness
Authors: Pepliński Marek
Published: September 2021

The paper refers to the argument from hiddenness as presented in John Schellenberg’s book The Hiddenness Argument and the philosophical views expressed there, making this argument understandable. It is argued that conditionals (1) and (2) are not adequately grounded. Schellenberg has not shown that we have the knowledge necessary to accept the premises as true. His justifications referring to relations between people raise doubts. The paper includes an argument that Schellenberg should substantiate its key claim that God has the resources to accommodate the possible consequences of openness to a relationship with finite persons, making them compatible with the flourishing of all concerned and of any relationship that may come to exist between them. At the end of the text, I propose to treat the argument as a rejection of an anthropomorphic God.
Benevolence or Mercy? The Problem with the First Premise of the Hiddenness Argument
Authors: Mordarski Ryszard
Published: September 2021

The first premise of J. L. Schellenberg’s Hiddenness Argument equates God’s love with a positive relationship to human beings. To illustrate this relationship, the human model of parental love is used, based on the standards of the modern American liberal world, not on the biblical standard. As a result, we attribute to God a narrowly understood horizontal relationship towards people, which is completely alien to the understanding of love developed in the Christian tradition. When we refer to the classical theism that recognized love as the central attribute of God, we will see that it should be understood in a vertical model, consisting in the offering of good and mercy. This understanding undermines the benevolent theism and replaces it with the merciful theism or theism of mercy. Ultimately, this makes the first premise of the Hiddenness Argument very questionable and the whole argument calls for a significant revision.
Dynamic Hip Screw versus Proximal Femoral Nail in the Management of Intertrochanteric Fractures - A Retrospective Analysis from Rajasthan
Authors: Dhaked Gajanand Shriram , Jaroli Abhishek Komalsingh , Malav Khushboo Parmanand , Rajpurohit Harish Narayan Singh
Published: September 2021

BACKGROUND Current management of Intertrochanteric (IT) fractures has evolved with the introduction of dynamic hip screw (DHS) and proximal femoral nail (PFN). The purpose of this study was to compare the functional outcomes between the DHS and PFN for IT fracture fixation. METHODS This study is a retrospective comparative analysis of 455 patients with IT fractures; DHS (292) and PFN (163), who were treated from June 2012 to June 2015. The patients were reviewed postoperatively for a minimum of 12 months to evaluate functional outcome using Salvati-Wilson score. Categorical data was present as absolute number or percentages, and parametric variables were presented as Mean ± SD, while non parametric data were presented as median. Statistical significance was defined as P < 0.05. RESULTS Intramedullary nails offer no advantage over extramedullary devices to treat IT fractures caused by low-energy trauma (AO 31 - A1). However, clinically significant outcomes were established for PFN group in terms of duration of surgery, x- ray exposure and SW Score for AO / OTA 31 - A2 and 31 - A3. Reoperations encountered for local pain due to implant prominence were significantly higher in the PFN group (4.90 % versus 1.02 %). Kaplan Meier survival probability of 69.3 % and 79.5 % predicted for DHS and PFN respectively, 3 years postoperatively. CONCLUSIONS Our conclusion reinforces indication for PFN in unstable IT fractures (31 - A2 and 31 - A3), owing to its better functional outcome and biomechanical properties. Functional outcomes for stable IT fracture (AO 31 - A1) were comparable between DHS and PFN, therefore final decision for implant choice depends on implant cost, surgeon’s preference for specific technique. However, understanding the morphology of proximal femur, peritrochanteric region is crucial to analyse the anatomical variations in Indian population which will provide the basis for intramedullary nail design modifications. KEYWORDS Intertrochanteric Fractures, DHS Fixation, PFN Fixation
On Iteration Method to The Solution of More General Volterra Integral Equation in Two Variables and a Data Dependence Result
Authors: MALDAR Samet
Published: September 2021

Fixed point theory is one of the most important theories and has been studied extensively by researchers in many disciplines. One of these studies is its application to integral equations. In this work, we have shown that the iteration method given in [12] converges to the solution of the more general Volterra integral equation in two variables by using Bielecki’s norm. Also, a data dependence result for the solution of this integral equation has been proven.
The Effects of Magnetic Iron Oxide Nanoparticles (Fe3O4) on Some Biological Aspects of Galleria mellonella L. (Lepidoptera: Pyralidae)
Authors: ESKİN Ayşe Nazan , ÖZTÜRK Şahlan , ESKİN Ata
Published: September 2021

In this study, 18-38 nm-sized and spherical-shaped nanopowder Fe3O4 NPs concentrations (0.4, 2, 10, 50, 250 µg/10 µl) was force-fed to sixth instar (180 ± 20 mg) Galleria mellonella (Lepidoptera: Pyralidae) larvae under laboratory conditions. The effects of magnetic iron oxide nanoparticles (Fe3O4) on the pupal and adult developmental times, pupal and adult weights and adult longevity of G. mellonella were recorded. Results showed that treating G. mellonella with 250 μg/10 µl Fe3O4 NPs significantly increased pupal weights. Additionally, while adult developmental time increased post 250 μg/10 µl Fe3O4 NPs treatment, it was observed that pupal developmental time, pupal and adult weights, and adult longevity were not statistically significantly different when compared to the control
СОЦІАЛЬНІ ЧИННИКИ ЗЛОЧИННОСТІ В УКРАЇНІ ТА РОЛЬ МОВНОГО ПРОСТОРУ У ВИКРИТТІ ДЕЯКИХ ЇЇ ПРОЯВІВ
Authors: АРКУША Лариса Ігорівна , СТЕПАНОВ Євгеній Миколайович
Published: September 2021

Мета статті полягає у класифікації соціальних чинників злочинності та визначенні ролі мовного простору у викритті окремих її проявів з урахуванням сучасних умов реформування правоохоронних органів та змін діючого законодавства. Об’єктом дослідження виступають лінгвістичні маркери злочинної діяльності. Предметом дослідження є соціально-мовні чинники злочинності та шляхи їх використання у розкритті злочину. Методологічною основою дослідження є система загальнонаукових і спеціальних методів наукового пізнання. Методи формальної логіки (аналіз, синтез, дедукція, індукція, аналогія) використано для з’ясування змісту наявних проблем, що виникають при вчиненні злочинів; метод структурно-функційного аналізу застосовано для дослідження мовленнєвої діяльності злочинців; метод системного аналізу – для визначення оптимальної лінії поведінки при використанні лінгвістичних знань у протидії злочинності; статистичний метод дає змогу дійти висновків щодо рівня використання лінгвістичних знань залежно від виду злочину. На підставі вивчення різних наукових точок зору і аналізу мовленнєвої практики осіб, залучених до вчинення злочину, зроблено висновки щодо необхідності підвищення рівня ефективності застосування визначених шляхів використання лінгвістичних знань у викритті окремих категорій злочинів. Результати дослідження мають бути впроваджені в практику здійснення авторознавчих лінгвістичних експертиз, у тому числі в процесі розкриття певних злочинів, а також враховані при розробці освітніх програм підготовки фахівців зі спеціальностей 081 – Право, 262 – Правоохоронна діяльність, у заходах із підвищення кваліфікації працівників правоохоронних органів.
КОМПАРАТИВНИЙ АНАЛІЗ СУЧАСНИХ ПЕРЕКЛАДІВ БІБЛІЙНОГО ТЕКСТУ
Authors: БУКРЄЄВА Лілія Леонідівна , КОЗАК Тетяна Борисівна
Published: September 2021

Метою статті є визначення функційної подібності тексту Біблії та тексту її перекладів на основі їх компаративного аналізу. Об’єктом наукового розгляду виступають стилістичні особливості російських перекладів біблійного тексту, який став предметом дослідження. У дослідженні з’ясовано характерні особливості двох сучасних перекладів старозавітної книги Пісня Пісень Соломона, виконаних з давньоєврейської мови російською, і визначити методом компаративного аналізу ступінь смислової і художньої розбіжності у досліджуваних текстах. Актуальність розгляду цього видатного літературного твору збереглася і дотепер, оскільки ця старозавітна книга цікава розмаїттям стилістичних прийомів, переклад яких вимагав від перекладачів протягом багатьох століть і творчого підходу, і надзвичайно широких фонових знань. Компаративний аналіз перекладів дав змогу визначити художній рівень двох сучасних перекладів Пісні Пісень і результат дослідження підтвердив факт, що досягнення функціональної тотожності перекладу з оригіналом виникає лише в тому випадку, коли перекладач уникає буквального копіювання оригіналу і намагається творчо втілити художні образи вихідного тексту у словесну тканину іншої мови. Висновки. Порівняння перекладів робить очевидним той факт, що велика кількість буквалізмів, невиправданих транслітерацій, стилістичних і логічних помилок у першому варіанті, виконаному за редакцією Давида Йосифона (1978), значно поступається за своїми художніми характеристиками другому перекладу Даат Мікра («Погляд на Танах», 2000). Наукова цінність роботи полягає в тому, що порівнювані сучасні переклади були виконані безпосередньо з давньоєврейської мови — мови оригіналу, на відміну від більшості перекладів, виконаних з давньогрецької мови, а результати пропонованої статті знайдуть своє практичне застосування у викладанні теорії та практики перекладу.
КОНТАМІНАЦІЇ ПОЛЬСЬКИХ КІНЕМАТИЧНИХ ФРАЗЕОЛОГІЗМІВ НА ПОЗНАЧЕННЯ ЕМОЦІЙ
Authors: ЛОЗИНСЬКА Оксана Григорівна
Published: September 2021

Мета статті – продемонструвати особливості структури, семантики та функціонування в текстах сучасної польської мови фразеологічних контамінацій як одного із типів структурно-семантичних інновацій, яких зазнають польські кінематичні фразеологізми на позначення емоцій. Об’єктом дослідження є контаміновані польські кінематичні фразеологізми на позначення емоцій; предметом аналізу – структурно-семантичні особливості контамінованих кінематичних фразеологізмів на позначення емоцій. Результатом дослідження є ґрунтовне вивчення текстової реалізації контамінованих кінематичних фразеологізмів, розкриття механізмів їхнього творення з урахуванням специфіки семантичного поєднання контамінованих фразеологізмів, встановлення різновидів контамінацій та спроба визначення причин їхньої появи. Висновки. З’ясовано, що значення контамінованих кінематичних фразеологізмів є результатом розширення – накладання, розгортання чи злиття – значень переважно двох вихідних нормативних фразеологізмів. Такі контамінації здебільшого вживаються для інтенсифікації значення одиниці шляхом схрещення значень поєднаних фразеологізмів. Найчастіше контамінуються дієслівні фразеологізми з іменними чи два дієслівні фразеологізми, значно рідше – обставинні з дієслівними чи два обставинні фразеологізми. При перехрещенні дієслівної одиниці  з іменною відбувається розгортання образу і/чи значення дієслівного фразеологізму, а при контамінаціях з формально-семантичним вузлом – накладання значень фразеологізмів.
ГЕНДЕРНІ ОЗНАКИ МОВЛЕННЄВОЇ ПОВЕДІНКИ ДІТЕЙ У ПОЕТИЧНИХ ТВОРАХ НАТАЛІЇ ЗАБІЛИ
Authors: ЯКОВЛЄВА Ольга Василівна
Published: September 2021

Об’єктом аналізу є сучасні багатозначні терміни лінгвістичної гендерології, які пов’язані з гендерним вихованням дітей дошкільного віку. Предметом  розгляду є основні поняття, що передують формуванню гендерної ідентичності у дітей. На матеріалі поезій видатної української письменниці радянських часів Н. Забіли описано гендерні характеристики мовленнєвої поведінки дітей. Результати аналізу дитячого мовлення, представленого поетесою у своїх творах, дають змогу стверджувати, що письменниця як багатодітна мати, яка пережила смерть двох донечок, абсолютно реалістично і з любов’ю описала різні прояви фемінності та маскулінності у дітей дошкільного віку. Авторкою статті зроблено висновок, що Н. Забіла, яка в маскуліноцентричному середовищі українських радянських письменників зробила блискучу кар’єру, текстами віршів для дітей і про дітей закріплювала позитивне ставлення до стереотипів фемінності та маскулінності, що репрезентують тексти традиційної культури українців, зокрема й тексти народних казок, які поетеса записала у віршованій формі. Правдивість віршів проявляється і в тому, що мовленнєва поведінка дівчат іноді репрезентує суто маскулінні риси характеру, а хлопчики, навпаки, у мовленні проявляють жіночі якості: чутливість, жалість, полохливість тощо. Вказано причини таких трансформацій.
AGRAVAMENTO DA VIOLÊNCIA DE GÊNERO NO CONTEXTO DA PANDEMIA DA Covid-19
Authors: Mesquita Aline Martins , Medeiros Anna Júlia Giurizatto , Barretto Elvira Simões , Silva Jerônimo da
Published: September 2021

Este trabalho realiza uma reflexão sobre o agravamento da violência de gênero em tempo de pandemia da Covid-19, com uma abordagem em âmbito nacional e internacional. Partindo de uma pesquisa bibliográfica, propõe uma narrativa que se encadeia a partir de elos de compreensão de que raízes da cultura da violência em sociedades capitalistas ocidentais,se retroalimentam para dar suporte à manutenção da ordem burguesa moderna, com parâmetros em um modelo referencial de organização androcêntrico.  Esta pesquisarefuta as interpretações equivocadas acerca da pandemia como responsável pelo aumento do fenômeno da violência de gênero, pois tal afirmativa nega a historicidade da violência de gênero. Defende, ainda,que a promoção de autonomia das mulheres, não somente do ponto de vista material, é de suma importância para o enfrentamento da violência de gênero.AGGRAVATION OF GENDER VIOLENCE IN THE CONTEXT OF THE Covid-19 PANDEMICAbstractThis work reflects on the aggravation of gender violence in the time of the Covid-19 pandemic, with a national and international approach. Based on a bibliographic research, a narrative is proposed defending the perception that the roots of the culture of violence in Western capitalist societies support the maintenance of the modern bourgeois order, with parameters in a referential model of androcentric organization. In this research, the misinterpretations about the pandemic as being responsible for the increase in the phenomenon of gender violence are refuted, as this statement denies the historicity of gender violence. It is argued that the promotion of women's autonomy, not only from a material point of view, is of paramount importance for fighting gender-based violence.Keywords: Gender violence. Pandemic. Covid-19. Brazil. World
IMPACTOS DA COVID-19: contradições e enfrentamentos em defesa da vida da população negra
Authors: Campos Margarida Cassia , Brito Angela Ernestina Cardoso
Published: September 2021

A presente pesquisa objetiva analisar, de forma inter-relacionada, três condicionantes: as fragilidades da implantação da Política Nacional de Saúde Integral da População Negra (PNSIPN), as condições de vulnerabilidade socioeconômica e o racismo estrutural na sua vertente de manifestação institucionalcomo determinantespara a compreensão dos índices de mortalidade pela Covid-19napopulação negra (pretos e pardos) no mês de julhode 2020 (semanas epidemiológicas 27ª a 31ª).Como metodologia, elege-se apesquisa quanti-qualitativa, com discussões interpretativas dos conceitose análise de dados da Pesquisa Nacional de Amostra por Domicílio de 2019 e do Ministério da Saúde (hospitalizados e mortos pela Covid-19).Os dados evidenciam a presença dos efeitos deletérios do racismo durante a pandemia.IMPACTS OF COVID-19: contradictions and confrontations in defense of the life of the black populationAbstractThis research aims to correlate three conditions: the weaknesses of the implementation of the National Policy for Integral Health of the Black Population (PNSIPN), the conditions of socioeconomic vulnerability and structural racism in its institutional manifestation aspect as determinants for the understanding of mortality rates by Covid-19 in the black population (blacks and browns) in the month of July 2020 (epidemiological weeks 27th to 31st). As a methodology, quanti-qualitative research is chosen, with interpretive discussions of the concepts and data analysis of the 2019 National Household Sample Survey and the Ministry of Health (hospitalized and killed by Covid-19). The data show the presence of the deleterious effects of racism during the pandemic.Keyword: Structural racism. Covid-19. Black population
O PROGRAMA MAIS MÉDICOS E SEUS IMPACTOS NO MERCADO DE TRABALHO MÉDICO DO BRASIL
Authors: Carreiro Gamaliel da Silva , Carreiro Paula Katiana da Silva , Sousa Antônio Paulino
Published: September 2021

O presente artigo tem o objetivo de apresentar de forma sistemática os resultados iniciais da pesquisa que analisa os impactos no campo da medicina de algumas políticas públicas implementadas durante os governos de Luís Inácio Lula da Silva e Dilma Rousseff (2003-2016) e que levaram, por um lado, ao aumento substancial do número de vagas e cursos de medicina no Brasil e, por outro, permitiram a entrada sem precedentes de mão de obra médica de outros países para atuar na saúde pública brasileira. A presente reflexão busca responder questões como: Quais as consequências para a classe médica de tão abrupta transformação? Quem se beneficiou com a ampliação da oferta dessa mão de obra no país? Como entender as mudanças no mercado de trabalho médico brasileiro em um contexto de grandes transformações macroeconômicas? E, finalmente, como o campo da medicina está reagindo a essas transformações?THE MORE DOCTORS PROGRAM AND ITS IMPACTS ON THE MEDICAL JOB MARKET IN BRASILAbstractThe present article aims to presente, in a systematically way, the initial results of the research that analyzes the impacts in the medical field of some public policies implemented during the PT governments (the workers party in Brazil) of Luís Inácio Lula da Silva and Dilma Rousseff (2003-2016), which brought the substantial increase in the number of vacancies and medical courses in Brazil and, on the other hand, allowed the unprecedented entry of medical labor from other countries to act in brazilian public health. The present reflection seeks to answer questions such as: What are the consequences for the medical class of such abrupt transformation? Who benefited from the expansion of this labor supply in the country? How to understand the changes in the brazilian medical labor market in a context of major macroeconomic transformations? At last, how the field of medicine is reacting to these transformations?Keywords: Field of medicine. Transformations. Brazil