bluuebunny/crossref_metadata_2025 huggingface dataset:
BRICS Alliance: A SWOT Analysis and the Potential Implications for Ending the Dominance of the USD
Authors: Alrefai A.
Published: October 2024

The group known as BRICS, comprising Brazil, Russia, India, China, and South Africa, came into being when its members decided to join hands to challenge the economic and political power of the wealthier nations of North America and Western Europe and expanded as BRICS+ when Egypt, Ethiopia, Iran, Saudi Arabia, and the United Arab Emirates entered the alliance with the same goals. Among the main reasons that led to the formation of the bloc was to put an end to the global dominance of the United States dollar (USD). Today, the BRICS+ bloc is motivated more than ever to find a solution to the ever-growing sanctions imposed by the United States (U.S.) on its member states as well as to cope with the fluctuating market situations that are merely based on the USD. The effectiveness of the newly expanded bloc’s alliance is the need of the hour, and for this purpose, the current study conducted a SWOT analysis to evaluate the bloc’s strengths, weaknesses, opportunities, and threats. The study took the facts and figures associated with the BRICS member states and their dealings with the U.S. and tried to analyze the effectiveness of this bloc should its members decide to conduct business with each other in a common currency. Furthermore, the study also evaluated the reasons behind the concept of de-dollarization and the benefits it offers the member states of the BRICS bloc. Additionally, the study proposes essential recommendations, such as the formulation of necessary measures to deal with potential disagreements that may arise regarding the choice of a common currency that should be used for trade among the member countries. Such an application of the study is an entirely novel application in the current area of research with the potential to open new horizons for future research considering the new targets of the BRICS+ group.
Desenvolvimento do Dispositivo de Segurança para Embalagens Plásticas
Authors: Fernandes Renan Lopes , Pinheiro Cristina Fidalgo Affonso , Junior Adauri Silveira Rodrigues , Trajano Eduardo Tavares Lima , Souza Maria Cristina Almeida de
Published: October 2024

Introdução: As intoxicações exógenas são definidas como manifestações clínicas dos efeitos nocivos à saúde produzidos no organismo vivo, decorrente da ingestão ou não de alguma substância química tóxica para o organismo. As crianças com faixa etária entre zero a quatro anos, são as principais vítimas dessas intoxicações, uma que vez que estão num período de desenvolvimento de habilidades, tendo uma curiosidade relacionada aos objetos ao seu redor. Materiais e métodos: Foi utilizado o SolidWorks® 2013 para desenvolvimento do “Dispositivo de Segurança para Embalagens Plásticas”, elaborado para evitar a abertura acidental do recipiente de produtos químicos de 5 litros. Resultados: O produto é constituído por dois componentes principais: uma trava da base e uma tampa com trava de segurança. Quanto à aplicabilidade, o dispositivo possui simplicidade de manuseio, podendo ser aplicado nas bombonas de 5 litros de capacidade, após o rompimento do lacre. Discussão: Uma busca mundial no banco de patentes analisou cinco produtos com diferentes graus de similaridade usados para fechamento de domissanitários. Entretanto, nenhum tinha a finalidade proposta pelo dispositivo aqui descrito, corroborando sua inventividade. Conclusão: O dispositivo possui caráter inovador, uma vez que pode ajudar na redução das intoxicações por domissanitários.
Palavras-chave: Acidentes; Crianças; Exposição a Produtos Químicos; Intoxicações; Segurança de Dispositivos.
Curcumin Modulates the Differential Effects of Fructose and High-fat Diet on Renal Damage, Inflammation, Fibrosis, and Lipid Metabolism
Authors: Melendez-Salcido Cecilia Gabriela , Ramirez-Emiliano Joel , Garcia-Ramirez Juana Rosalba , Gomez-García Anel , Perez-Vazquez Victoriano
Published: October 2024

Background:

Dyslipidemia and obesity hypercaloric diet-induced lead to kidney damage. We investigated
the effect of curcumin on the expression of proteins related to inflammation, fibrosis, fatty acids
metabolism, kidney damage, and morphological changes in the kidneys of mice hypercaloric diets-fed.

Methods:

Groups of 5-week-old C57BL/6 mice (n=6) were formed: Control (C), High-fructose diet (F), Highfructose
diet and curcumin (F+Cur), High-fat diet (HFD), High-fat diet and curcumin (HFD+Cur), High-fat diet
and fructose (HFD+F), High-fat diet, fructose and curcumin (HFD+F+Cur), treated for 16 weeks with 30%
(w/v) fructose, 60% (w/w) fat and 0.75% (w/w) curcumin. Kidneys were obtained for histomorphological and
Western Blot analysis.

Results:

Curcumin prevented TNF-α overexpression in the F and HFD+F groups. VLCAD expression was
higher in the F, HFD, and HFD+F groups. PPARγ expression was lower in the F+Cur, HFD+Cur, and
HFD+F+Cur groups. Curcumin prevented overexpression of CPT1 and KIM1 in the HFD+F and HFD groups.
Curcumin prevented morphological lesions, fibrosis, and lipid deposition that were hypercaloric diet-induced.

Conclusion:

Chronic consumption of hypercaloric diets causes inflammation, fibrosis, and lipid deposition in
the kidney. It is suggested that curcumin prevents renal structural damage, limits tissue lipid deposition, and
differentially modulates renal injury depending on diet composition in mice fed high-fat and/or high-fructose
diets.
Effective Components and Molecular Mechanism of Biejiaruangan Capsule Against Liver Fibrosis: High-resolution Mass Spectrometry, Network Pharmacological Analysis and Experimental Verification
Authors: Cao Kefeng , Jiang Hui , Zhang Lili , Fan Chang , Feng Zhigang , Li Biao , Song Laicheng , Zhang Qun
Published: October 2024

Background:

Biejiaruangan capsule (BJRGC) is a commonly used traditional Chinese
medicine preparation for treating oftreating liver fibrosis (LF), but its specific molecular mechanism
is unclear. This study used mass spectrometry, network pharmacology and experimental
verification to explore the mechanism of BJRGC against LF.

Methods:

Ultrahigh-performance liquid chromatography-quadrupole-exactive-orbitrap-mass
spectrometry (UHPLC-Q-Exactive-Orbitrap-MS) and network pharmacology were employed to
identify and screen the potential components, targets, and signaling pathways of BJRGC against
LF. The interaction between the active ingredients and targets was validated using molecular
docking. Finally, 5-ethynyl-2'-deoxyuridine (EDU) staining, western blotting (WB), and flow cytometry
(FCM) were utilized to further verify the mechanism of BJRGC against LF.

Results:

A total of 9 prototype components of BJRGC were identified in serum, most derived
from iridoid glycosides and triterpenes in Gardenia jasminoides Ellis and Artemisia scoparia
Waldst.et Kit. Network pharmacology predicts that medicine prototype components in serum
mostly influence targets such as CDK2, CDK6, and PIK3CG, with the key route being the
PI3K/AKT signaling pathway. Molecular docking showed that the major components have good
binding properties with key target proteins. The experimental results showed that BJRGC could
inhibit the proliferation of HSCs, induce cell cycle arrest and reduce the protein expression of
CDK2, CDK6 and PIK3CG.

Conclusions:

BJRGC can inhibit the proliferation of HSCs by targeting the protein expression of
CDK2, CDK6, and PIK3CG in the PI3K/AKT signaling pathway through its prototype components,
such as hyperoside, tumulosic acid, and hederagenin, thereby alleviating LF disease.
Integrated Transcriptomics and Metabolomics Studies Reveal Steroid Biosynthesis Pathway and BCL2 Inhibitory Diazo-Progesterone of Drimia
indica for Conservation and Sustainable Utilization
Authors: Shit Vivek , Dhakar Mahesh Kumar , Kumar Manoj
Published: October 2024

Background:

This study is the first report on the sequence of the transcriptome of
Drimia indica, a non-model plant with medicinal properties found in a forest tribal belt, using
the Illumina NovaSeq platform. The primary objectives of this study were to elucidate the gene
expression profiles in different tissues, identify key regulatory genes and pathways involved in
secondary metabolite biosynthesis, and explore the plant's potential pharmacological properties.

Methods:

The study generated 670087 unigenes from both leaves and roots and identified putative
homologs of annotated sequences against UniProt/Swiss-Prot and KEGG databases. The
functional annotation of the identified unigenes revealed the secondary metabolite biosynthetic
process as the most prominent pathway, with gene enrichment analysis predominantly accounting
for secondary metabolite pathways, such as terpenoid, steroid, flavonoid, alkaloid, selenocompound,
and cortisol synthesis. The study also identified regulatory genes NAC, Bhlh,
WRKY, and C2H2 on the transcriptome dataset.

Results:

The functionally annotated unigenes suggested phytocompounds in Drimia indica to
have multi-potent properties, such as anti-cancer, anti-inflammatory, and anti-diabetic activities,
which has been further validated by GC-MS-based metabolite profiling. Notably, we have identified
two novel molecules, di-azo progesterone and 4H-pyran-4-one 2,3-dihydro-3,5-dihydroxy-
6-methyl, with potential BCL2 inhibitory anticancer properties, supported by stable binding interactions
observed in molecular docking and dynamics simulations. Additionally, an abundance
of mono-nucleotide SSR markers has been identified, useful for genetic diversity studies.

Conclusion:

This study provides a foundational understanding of the molecular mechanisms in
Drimia indica, highlighting its potential as a source for novel therapeutic agents and contributing
valuable insights for future pharmacological and agricultural applications. However, further in
vivo studies are warranted to confirm these findings and validate their pharmacological efficacy
and therapeutic potential. The SSR markers identified also offer valuable tools for molecular
genetics, plant breeding, and sustainable drug development.
The Apoptotic, Cytotoxic, and Anti-migration Effects of Sodium Deoxycholate in a Breast Cancer Cell Line and its Modulation on PON1 as a Predictive Risk Marker
Authors: Tülüce Yasin , Alhammud Huda , Keleş Ahmet Yasin , Köstekci Sedat
Published: October 2024

Introduction:

Breast cancer is the most prevalent cancer among women
and is usually treated with antineoplastic drugs. The present study examines the
influence of sodium deoxycholate on the molecular pathways underlying apoptosis,
cytotoxicity, and the modulation of PON1 in the MCF-7 breast cancer cell line. Various
doses were administered to test the hypothesis that it could potentially affect cancer
cells.

Method:

The study examined the cytotoxic effect of sodium deoxycholate on MCF-7
cells and human mammary epithelial cells (CRL-4010) using the MTT method to detect
its anticancer properties. Subsequently, the efficacy of the active dose on DNA
fragmentation and apoptosis was examined using the apoptotic DNA ladder and
Western blot methods. Additionally, oxidative stress index and cell migration tests
were conducted. Notably, sodium deoxycholate did not cause DNA damage despite
demonstrating cytotoxic effects on cells.

Results:

The study found that sodium deoxycholate increased the levels of several
pro-apoptotic proteins, leading to apoptosis. Moreover, it markedly diminishes the
activity of paraoxonase and arylesterase of PON1, which are predictive risk markers
for cancer. Furthermore, it was found to delay cell migration in a time-dependent
manner.

Conclusion:

These findings suggest that sodium deoxycholate exhibits an
antimetastatic effect in breast cancer cells, could be a valuable subject for further
cancer research.
Cognitive Behavioral Therapy in Cardiovascular Disease
Authors: Manolis Theodora A. , Manolis Antonis A. , Manolis Antonis S.
Published: October 2024

Introduction/Objective:

The influence of cognitive behavioral therapy (CBT) and its
modalities on various neuropsychiatric conditions is herein explored together with their impact on
specific cardiovascular (CV) diseases (CVD).

Methods:

A comprehensive review of the literature was undertaken via the PubMed, Scopus and
Google Scholar on the above relevant topics. The focus was on large randomized controlled trials
and meta-analyses.

Results:

Among the various neuropsychiatric disorders, depression and anxiety commonly occur
in CVD patients, frequently eluding clinician's attention. This reciprocal liaison may incur higher
rates of morbidity/mortality, through physiological and behavioral mechanisms. Multimodal
psychiatric interventions, using medications and psychotherapies, such as CBT, seem promising.
Such mindfulness-based interventions have the potential to be an efficacious complementary strategy
to address psychological stress in CVD patients. As the cost of CBT is relatively low, such a
supportive approach for stress management provides high patient acceptability, with a positive impact
on improving quality of life, by promoting CV health and mitigating CV complications.

Conclusion:

There is ample evidence of a reciprocal liaison between heart and mind. Several CV
risk factors are strongly affected by diseases of the mind, and the clinical course of various CVDs
is influenced by affective or other psychiatric disorders. CBT and relevant mindfulness-based interventions
have a significant supportive role in patients with various CVDs by targeting CV risk
factor(s) or the underlying specific CVD and by identifying and addressing psychosocial issues. In
this direction, various CBT interventions can provide the means to favorably influence both CV
risk factors and CVDs.
Innovative Synthesis of 3,5-Disubstituted Pyrazoline with Heterocyclic System for Hybrid Development
Authors: Chauhan Anurag , Salahuddin  , Mazumder Avijit , Kumar Rajnish , Ahsan Mohamed Jawed , Yar Mohammad Shahar , Kumar Arvind , Kapoor Bhupinder
Published: October 2024

The synthesis of 3,5-disubstituted pyrazolines, integrated with heterocyclic systems, represents
a crucial area of chemical research due to their pharmacological and biological significance. This
article reviews various synthetic methods used to prepare 3,5-disubstituted pyrazolines with different
heterocyclic groups. The methodology employed in this study entails a multi-step synthesis, where
readily available starting materials are transformed into complex pyrazoline derivatives through strategic
reaction sequences. Incorporating heterocyclic systems not only enhances the structural diversity
but also imparts unique chemical and biological properties to these compounds. Various heterocyclic
groups, such as furans, thiophenes, and pyridines, are introduced at the 3,5-positions of the pyrazoline
ring, yielding a versatile library of compounds. This study highlights the potential applications of these
novel compounds in medicinal chemistry and drug discovery, emphasizing their bioactivity against
specific targets. Preliminary data suggests that certain derivatives possess promising pharmacological
activities, making them potential candidates for further development as therapeutic agents. In summary,
this review provides a valuable contribution to the field of organic synthesis, offering a novel
and efficient route to synthesize 3,5-disubstituted pyrazolines with heterocyclic systems. Furthermore,
the structural activity relationship of the compounds is also discussed. The structural diversity and
potential pharmacological properties of these compounds make them valuable candidates for further
exploration and development in drug discovery and related areas.
Stevia By-product Fraction has Antioxidant Capacity and has been Evaluated for its Antihyperglycemic and Antilipid Potential
Authors: Letícia Serra Cabeça Cynthia , Campangolli Pereira Betânea , Caroline Nogueira Natani , Leonardo Marotti Siciliano Paulo , Rosa Trentin Zorzenon Maria , Sergio Dacome Antonio , Kazue Enokida Milena , de Oliveira Souza Felipe , Godoi Silva Pauline , Rodrigues de de Oliveira Adan , Jorge Pilau Eduardo , Claudio da Costa Silvio , Gimenez Milani Fernandes Paula
Published: October 2024

Introduction/Objective:

The ethanolic pretreatment of stevia leaves is considered ecologically
favorable and increases its yield, purity level, and sensory profile of sweeteners. We
investigated the by-product generated so that we can provide a viable and applicable destination
to effectively contribute to the production and industrial chain of stevia sweeteners. Recently, an
antioxidant and antidiabetic fraction was obtained through stevia methanolic extraction. However,
this process is costly, has a low yield, and is non-green. In this study, we got an antioxidant
fraction of stevia from its pretreatment by-product, the ethanolic extract, characterized its bioactive
compounds – mainly phenolic acids and flavonoids – and evaluated its antidiabetic and antilipid
capacity.

Methods:

The ethanolic extract was fractionated, then the ethyl acetate fraction was microencapsulated.
Physicochemical, Mass Spectrometry (UHPLC/MS-MS), scanning electron microscopy,
microencapsulation efficiency, and antioxidant capacity analyses were carried out. The antioxidant
capacity was evaluated. Antihyperglycemic capacity was assessed by inhibition
of α-glucosidase and α-amylase. For antilipid potential, inhibition of pancreatic lipase was
measured.

Results:

Antioxidant potential was observed mainly in the fraction. Microencapsulation improved
the stability of the fraction. Mass spectrometry allowed comparison with phenolic and flavonoid
compounds from the methanolic and ethanolic fractions of the by-product. Many compounds
were coincident, which may explain the similar antioxidant capacity found. The samples showed
more than 90% inhibition of alpha-glucosidase, which may indicate potential antidiabetic activity.
All samples showed inhibition of the pancreatic lipase enzyme higher than 80%, reaching 91.05%
for the free fraction.

Conclusion:

This study represented the recovery of a by-product and showed that this antioxidant
fraction deserves further investigation for its bioactive potential, especially antioxidant, antidiabetic,
and anti-lipid.
A Comprehensive Review on Role of Natural Polymers in Gastro Retentive Drug Delivery System (GRDDS)
Authors: Singh Manisha , Das Manas Kumar
Published: October 2024

This review is to present a general outline of potent & promising natural polymers (on
which only slight research is done) along with their attributes & their pharmaceutical functions in
the development of GRDDS (gastro retentive drug delivery system). Therefore, there is a need of
more attention & focus on some of these natural polymers which are playing a crucial & indispensable
role in the fabrication of GRDDS. Recent & current research trends shows that progressively
natural polymers are replacing synthetic polymers in the fabrication of GRDDS as they are more
safe, non-toxic, biodegradable, biocompatible, economical, regulatory acceptance, etc. Also, it has
been noticed by the researchers that natural polymer due to their properties have successfully amplified
gastric residence time, dissolution & bioavailability of the gastroretentive dosage forms.
Ginsenosides as Promising Therapeutic Agents for Glioma: Mechanisms of Action and Future Perspectives
Authors: Moftakhar Arya , Najafi Sajad , Khoshnam Seyed Esmaeil , Farzaneh Maryam
Published: October 2024

Brain cancers, particularly gliomas, are a significant cause of mortality worldwide. Gliomas
are primary tumors of the central nervous system (CNS) and are characterized by diverse clinical
and biological features. Despite advancements in clinical approaches and surgical techniques,
the treatment of high-grade gliomas still poses multiple challenges. This article focuses on a key active
substance found in Panax ginseng called Ginsenosides. Ginsenosides belong to a specific class
of triterpenoid saponins and have demonstrated various therapeutic effects, including neuroprotective,
anticancer, anti-inflammatory, and neuroprotective functions. These compounds have shown
potential in the treatment of gliomas and other cancers. Several pathways associated with ginsenosides,
such as Rg3, Rh2, Rd, and Rb1, have been extensively studied, and these compounds have
been proposed as potential targets in glioma treatment. The precise mechanisms of action of ginsenosides
in gliomas are still being investigated, but their ability to modulate various signalling
pathways and exert multiple therapeutic effects makes them promising candidates for further research
and development. Clinical trials and additional studies are necessary to validate their therapeutic
benefits and determine the optimal dosage, administration route, and potential combination
with other treatment modalities. In summary, ginsenosides, the active compounds found in Panax
ginseng, exhibit various therapeutic effects, including potential anti-cancer properties in gliomas.
Their ability to modulate multiple pathways makes them promising targets for further research in
the field of glioma treatment. However, more studies are required to establish their effectiveness
and safety in clinical settings.
Isotype Profile of Specific Antibodies after Chronic Exposure to Microcystins
Authors: Ruiz Marcia A. , Ferrari Alejandro , Rodriguez Maria I. , Flanagan Cristian , Lerda Daniel , Romero Marta D. , Halac Silvana R. , Ruibal-Conti Ana L.
Published: October 2024

Background:

The detection of microcystins in blood, respiratory mucosa, and urine samples to diagnose acute or chronic microcystin intoxication is difficult and requires sophis-ticated analysis techniques. Finding simple and quick methods to assess the exposure of indi-viduals to microcystins is crucial.

Objective:

This study aims to assess the presence of specific antibodies (IgG, IgE, IgA, and IgM) against microcystin-LR in individuals exposed to cyanobacterial blooms as a non-com-plex biomarker.

Methods:

Blood samples were taken to reveal the presence of specific antibodies as well as to measure a standard set of biochemical parameters. All volunteers were administered a ques-tionnaire regarding their water usage, health status, and habits. Significant differences in the antibody content were studied between exposed and non-exposed people to cyanobacterial blooms.

Results:

We found that out of 73 studied individuals, 87.7% of them showed positive results for at least one of the four types of antibodies tested. The prevalent isotype was IgE, and sig-nificant differences were detected for all isotypes between the exposed and non-exposed groups. The biochemical profile was altered in some cases.

Conclusion:

The presence of specific antibodies in serum could be used as exposure biomarkers to complement epidemiological studies and medical diagnosis of microcystin intoxications. The in-house ELISA method, developed by our group for the detection of antibodies, should now be improved in terms of specificity and accuracy. These findings also indicate that more re-search should be conducted on the protective role and duration of antibodies.
Impact of Ultra-Processed Foods on Food Sustainability: Exposure Assessment and Health Implications
Authors: Chadha Muskan , Shukla Ratnakar , Kumar Tiwari Rohit , Kumar Dubey Dharmendra , Singh Karuna
Published: October 2024

Excessive consumption of ultra-processed food (UPF) is a global health concern as-sociated with an increased incidence of non-communicable diseases. UPFs are characterized by their extensive industrial processing and high content of additives, preservatives, chemicals, and artificial ingredients that are used to mask defects or inferior ingredients of end food products, presenting a multifaceted challenge to contemporary society. Exposure assessment showed that almost 50% to 30% of the energy consumption per day comes from UPFs. The more processed a food is, the less likely it is to be healthy and nutritious. UPFs affect human health by increasing the risk of obesity, heart disease, cancer, depression, diabetes, etc., as these foods are typically made up of a large number of preservatives, high content of fats, sodium, and sugars, and low contents of protein, fiber, and potassium. The ingredients required for the production of UPFs are commonly derived from intensive monoculture and livestock of raw foods. This, in turn, exerts imminent effects on agriculture, biodiversity, and the global food system by altering the bioavailability of nutrients within agricultural soil, thereby increasing the dependency on ferti-lizers and insecticides. Recent studies have shown that over-consumption of UPF has an effect on culinary traditions, loss of biodiversity, human well-being, and food system sustainability. Therefore, for better food system sustainability, the consumption of UPFs should be reduced, and we should move toward minimal processing technologies, preferably for seasonal and or-ganic local products. Based on available data, there is an urgent need to implement policies and regulations for the agro-food industry to include nutritional and environmental criteria. This review explains the different dimensions of UPFs in relation to health, nutrition, environment, current challenges, future innovations, and wider sustainability concerns.
Metabotropic Glutamate Receptor 5: A Potential Target for Neuropathic Pain Treatment
Authors: Manengu Chalton , Zhu Chun-Hao , Zhang Guo-Dong , Tian Miao-Miao , Lan Xiao-Bing , Tao Li-Jun , Ma Lin , Liu Yue , Yu Jian-Qiang , Liu Ning
Published: October 2024

Neuropathic pain, a multifaceted and incapacitating disorder, impacts a significant number
of individuals globally. Despite thorough investigation, the development of efficacious remedies for
neuropathic pain continues to be a formidable task. Recent research has revealed the potential of
metabotropic glutamate receptor 5 (mGlu5) as a target for managing neuropathic pain. mGlu5 is a receptor
present in the central nervous system that has a vital function in regulating synaptic transmission
and the excitability of neurons. This article seeks to investigate the importance of mGlu5 in neuropathic
pain pathways, analyze the pharmacological approach of targeting mGlu5 for neuropathic
pain treatment, and review the negative allosteric mGlu5 modulators used to target mGlu5. By comprehending
the role of mGlu5 in neuropathic pain, we can discover innovative treatment approaches to
ease the distress endured by persons afflicted with this incapacitating ailment.
A Context Aware Decision-Making Algorithm for Human-Centric Analytics: Algorithm Development and Use Cases for Health Informatics System
Authors: A Veena , S Gowrishankar
Published: October 2024

This reference demonstrates the development of a context aware decision-making health informatics system with the objective to automate the analysis of human centric wellness and assist medical decision-making in healthcare.

The book introduces readers to the basics of a clinical decision support system. This is followed by chapters that explain how to analyze healthcare data for anomaly detection and clinical correlations. The next two sections cover machine learning techniques for object detection and a case study for hemorrhage detection. These sections aim to expand the understanding of simple and advanced neural networks in health informatics. The authors also explore how machine learning model choices based on context can assist medical professionals in different scenarios.

Key Features :

-Reader-friendly format with clear headings, introductions and summaries in each chapter

-Detailed references for readers who want to conduct further research

-Expert contributors providing authoritative knowledge on machine learning techniques and human-centric wellness

-Practical applications of data science in healthcare designed to solve problems and enhance patient wellbeing

-Deep learning use cases for different medical conditions including hemorrhages, gallbladder stones and diabetic retinopathy

Demonstrations of fast and efficient CNN models with varying parameters such as Single shot detector, R-CNN, Mask R-CNN, modified contrast enhancement and improved LSTM models.

This reference is intended as a primary resource for professionals, researchers, software developers and technicians working in healthcare informatics systems and medical diagnostics. It also serves as a supplementary resource for learners in bioinformatics, biomedical engineering and medical informatics programs and anyone who requires technical knowledge about algorithms in medical decision support systems.
ANALISIS PENGARUH DAMPAK MAKROEKONOMI, KEBIJAKAN PEMERINTAH, DAN KINERJA PERUSAHAAN TERHADAP RETURN SAHAM SEKTOR INFRASTRUKTUR
Authors: Achmad Usman Maulana  , David Kaluge
Published: October 2024

Infrastructure sector stocks experienced a stable and upward trend, even sharply at the end of quarter 2023. In line with the government budget in infrastructure development that continues to increase, supported by the increase in this sector, one of which will contribute to increasing economic growth in Indonesia, therefore the purpose of this research is to analyze the effect of macroeconomic impacts, government policies, and company performance on infrastructure sector stock returns. Inferential quantitative research with panel data regression analysis techniques is included in this research. With purposive sample method, ten companies were selected, out of 62 companies in the whole population. The type of secondary data is quarterly for the period 2016-2022. The implications of this research as material for investors to invest. Common Effect Model (CEM) is the selected model, the findings prove that partially interest rates, capital expenditures, CR, TATO, ROE, PER, DER, ROA, EPS, NPM, DPR, and DPS have no effect on stock returns. PBV has a significant positive effect on stock returns. Exchange rate, inflation, and DY variables have a significant negative effect on stock returns. Simultaneously, exchange rate, inflation, interest rate, capital expenditure, CR, TATO, ROE, PER, DER, ROA, EPS, PBV, NPM, DPR, DPS, and DY all affect stock returns.
Aphrodisiac Activity of Beligo (Benincasa hispida (Thunb.) Cogn.) Seeds of Ethanol Extract in Mice
Authors: Alim Nur , Jasmiadi Jasmiadi , Nadillah Nadia , Indrawaty Kadir Ira , Afirah Nur
Published: October 2024

Beligo (Benincasa hispida (Thunb.) Cogn.), is empirically used by the people of South Sulawesi-Indonesia as an aphrodisiac. Beligo seeds contain alkaloids, phenolics, flavonoids, and unsaturated fatty acids, which have the potential to act as aphrodisiacs. The primary objective of this research is to determine the aphrodisiac activity of an ethanol extract from beligo seeds in mice.  The procedure entails extraction and aphrodisiac evaluation using introduction, climbing, and coitus test parameters. Aphrodisiac testing was carried out for seven days using 25 mice as experimental animals, divided into five groups. Each group consists of four males and one female. Group I was given Sod. CMC 1% as a negative control; II, III, and IV were given ethanol extracts of beligo seeds at doses of 350mg/kg, 700mg/kg, 1400mg/kg BW, and group V, as a positive control, was given Yohimbine. The results showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW, 700mg/kg BW, and 1400mg/kg BW had aphrodisiac activity (p=0.0001) compared to Sod. CMC 1% based on data on the amount of introduction and climbing. However, based on data on the number of coitus, it showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW (p=0.072) had no aphrodisiac activity, 700mg/kg BW (p=0.007), 1400mg/kg BW (p=0.0001) had aphrodisiac activity compared to Na-CMC 1% and only a dose of 1400 mg/kg BW had the same aphrodisiac activity compared with Yohimbine (p=0.967). It is concluded that the ethanol extract of beligo seeds had aphrodisiac activity.
Derechos Individuales y Decisiones Colectivas: Reflexión sobre el suicidio asistido y el Right To Try en Colombia
Authors: Gómez-García Carlos A , Molina Moreno Valeria , Moreno Verbel Esteban
Published: October 2024

El objetivo principal de este artículo reflexivo es examinar cómo se entrelazan los principios de derecho, bioética y autonomía en los debates sobre el suicidio asistido y el 'Right to Try' en Colombia. Se propone analizar las implicaciones legales, éticas y sociales de estas prácticas en el contexto del sistema de salud colombiano. La pregunta que propone abordar es ¿Cómo se entrelazan los principios de derecho, bioética y autonomía en los debates sobre el suicidio asistido y el 'Right to Try' en Colombia? y ¿Cuáles son las implicaciones legales, éticas y sociales de estas prácticas en el contexto colombiano? Metodología: A través de un análisis multidisciplinario, se ha demostrado que estos debates son complejos y están marcados por tensiones entre los derechos individuales y los valores sociales. Se ha evidenciado que estas esferas plantean desafíos significativos en la toma de decisiones y políticas en materia de salud. Conclusiones: En este sentido, se concluye que es fundamental abordar estos temas desde una perspectiva integral que considere tanto los aspectos legales como los éticos y sociales, con el fin de garantizar el respeto a la dignidad humana y proteger los derechos fundamentales
Hydrodynamic properties of propellers with large blade-area ratio and truncated blade in free water
Authors: Afanasyev A. K. , Revenko E. S. , Ushakov K. M.
Published: October 2024

In the literature exist data about the hydrodynamic characteristics of propulsion systems, which include a duct and a fixed-pitch propeller with a truncated blade shape (Kaplan propeller), which has a relatively small blade-area ratio of 0.55. Usual such propellers has a very high loading coefficient, which entails the need to increase propellers blade-area ratio in order to prevent the occurrence of developed cavitation. The article presents the results of the first stage of research, which included testing a series of four-blade truncated propellers with a blade-area ratio 1.0 in free water. The tests were carried out in the towing tank of Admiral Makarov State University of Maritime and Inland Shipping on experimental installation, which include a special hydrodynamic stand. A series of tested propellers were 3D printed from PET-G plastic. A preliminary assessment showed that the chosen diameter of the models will ensure the achievement of supercritical Reynolds numbers at a rotation frequency of about 20 s–1. However, during the tests, it was found that the rotational speed must be increased to 30 s–1, which, in turn, led to a reduction in the test program due to the regime limitations of the experimental equipment. Nevertheless, the analysis of the test results made it possible to build a “hull” and “machinary” diagrams according to the Papmel form. An assessment of the strength of the models was carried out, which showed that the stresses arising in the root of the blade are significantly less than the allowable ones. The obtained results expand the design possibilities of Kaplan propellers with water-jet propulsion units, as well as a part of the “propeller-nozzle” propulsion complex.
Analysis of the application of natural circulation of cooling media in shipboard reactor installations
Authors: Korolev V. I.
Published: October 2024

In projects of floating facilities with a nuclear power plant, great importance is attached to the formation of a set of properties of the internal self-protection of the reactor, i. e. the development of properties that ensure its safety based on natural feedbacks, processes and characteristics. To do this, the RU project is based on physical patterns and technical solutions that prevent or minimize possible consequences from emergency situations. In particular, the natural circulation of the coolant in case of loss of power supply by the circulation pumps of the first round allows cooling the core after its transfer to a subcritical state. However, in order for a natural circulation to occur sufficient to ensure nuclear and radiation safety, certain conditions must be met in a particular case. The paper notes that the most important property of reactor installations of nuclear vessels is their ability to ensure natural circulation of the coolant in emergency situations, as well as when operating at capacity. This makes it possible to reduce the dependence of reactor plant safety on the technical condition of power supplies. Currently, natural circulation of auxiliary cooling media in passive safety systems is also widely used in reactor installations. These include emergency reactor cooling systems using an emergency cooling system, including using intermediate heat exchangers; reducing emergency pressure in the protective shell in case of an accident with a large coolant leak; cooling the reactor vessel in an out-of-design accident with the formation of corium. The paper proposes a method for preliminary analysis of the reactor plant’s ability to ensure natural circulation of the coolant, which allows us to compare various design solutions that contribute to an increase in coolant consumption during natural circulation. It is shown that for the operation of the reactor plant in stand-down mode and at energy power levels with natural circulation of the coolant, it is advisable to switch to boiling reactors. Passive safety systems using natural circulation have received special development on new nuclear vessels of projects 20870, 22220, 10510. Further development of safety systems using natural circulation to move cooling media is predicted.
Economical management of diesel generator sets by means of MATLAB digital technologies
Authors: Baryshnikov S. O. , Sakharov V. V. , Chertkov A. A.
Published: October 2024

A numerical algorithm for optimizing the technological processes of diesel generator sets operating on various grades of fuel, implemented by means of CVX-technologies, is considered. Traditional algorithms have generally proven to be positive, but can be problematic for optimization due to the large number of variables and the nonlinearity of the model. In addition, due to the huge computational load, they can “stall” or become damaged when used to search for non-standard designs, such as asymmetric D-optimal and large-dimensional spatial structures. It is noted that an alternative to them is calculations in the CVX format, which are widespread and available for solving convex optimization problems. However, their application for the control of technological processes of energy saving in autonomous electric power complexes in transport is still limited. Based on the tools of the CVX package in MATLAB, using their usefulness and flexibility in comparison with traditional optimization methods, this paper proposes technical solutions aimed at developing energy-saving technologies for energy complexes of autonomous systems in the context of digital transformation. The application of energy saving management methods is presented in this study on the example of fuel consumption management by a group of diesel generators with different consumption characteristics of primary engines, for which optimal modes have been obtained at various options of active power consumption by the network. An example of calculating optimal modes in parallel operation of five DGA with CVX program codes is given, confirming the correctness of the proposed solutions. It is shown that the use of CVX programs in MATLAB demonstrates their usefulness and flexibility in comparison with traditional algorithms in the statistics of searching for various types of optimal approximate constructions by convex criterion for nonlinear models.
ENHANCING VEHICULAR NETWORKS WITH DEEP RADIAL BASIS FUNCTION FOR INTELLIGENT TRAFFIC MANAGEMENT
Authors:   Sri Indu College of Engineering and Technology, India, S Vijayarangam , N Sivakumar ,   Varuvan Vadivelan Institute of Technology, India, W Agitha ,   DMI College of Engineering, India, Mallick Mohamed ,   Samsung, Bengaluru, India
Published: October 2024

The vehicular networks has spurred research into intelligent traffic management systems to alleviate congestion and enhance safety. However, existing approaches often face challenges in capturing the complex dynamics of urban traffic flow efficiently. In this study, we propose an innovative framework integrating Deep Radial Basis Function (DRBF) networks into vehicular networks for intelligent traffic management. Our approach aims to address the limitations of conventional methods by leveraging the representational power of deep learning while incorporating the flexibility of radial basis function networks. The problem addressed in this research lies in the inadequacy of traditional traffic management systems to adapt to the dynamic nature of urban traffic flow. Existing methods often rely on simplistic models or predefined rules, which may fail to capture the intricate patterns and interactions among vehicles on the road. Consequently, these systems may struggle to provide real-time and accurate traffic management solutions, leading to increased congestion and safety hazards. To bridge this research gap, we propose the integration of DRBF networks, which offer a unique combination of deep learning capabilities and radial basis function interpolation. This hybrid architecture enables the model to learn complex spatial and temporal dependencies from vehicular network data while maintaining computational efficiency and interpretability. By training the DRBF network on historical traffic data and real-time sensor inputs, our methodology can effectively predict traffic flow, identify congestion hotspots, and optimize route recommendations in urban environments. Experimental results on real-world traffic datasets demonstrate the effectiveness of the proposed approach in enhancing traffic management performance. Compared to traditional methods, our DRBF-based framework achieves higher accuracy in traffic flow prediction and generates more efficient routing strategies, leading to reduced travel times and improved overall traffic conditions.
SSD DISCORE - A SCORING METHOD FOR SSD'S DATA INTEGRITY VALIDATION USING DIFFERENT SMART ATTRIBUTES IN THE DIGITAL FORENSICS PROCESS
Authors:   Srinivas University, India, Pallivalappil Abdul Shareef , S N Jagadeesha ,   Srinivas University, India
Published: October 2024

Solid-state drives (SSD) are replacing hard disk drives (HDD) in the majority of computer systems today. Because SSDs outperform HDDs in terms of efficiency, SSDs are now more necessary to replace HDDs. However, due to uncertain data integrity, SSDs are not forensically sound in design. The data on SSD is continuously changing as a result of Wear Leveling, TRIM and Garbage Collection, which makes data integrity verification in digital forensics challenging. The use of hash algorithms to validate data integrity is crucial in establishing the legitimacy of evidence gathered from suspect systems. In order to shed light on this matter, an experiment was carried out to gather data from an SSD in both user active and user non-active state. The data was then analyzed using the different attributes of Self-Monitoring, Analysis, and Reporting Technology (SMART) to ascertain the data integrity and by proposing a scoring method “SSD DiScore (SSD Data Integrity Score)”, which can aid in digital forensic investigation procedure.
ADVANCES IN NETWORK SECURITY FOR A RESILIENT DIGITAL CYBERSPACE INFRASTRUCTURE
Authors:   Vaageswari College of Engineering, India, Udutha Rajender , Kumar Sunil ,   Auro University, India, Rao Allanki Sanyasi ,   Christu Jyothi Institute of Technology and Science, India, Dhanikonda Srinivasa Rao ,   BVRIT Hyderabad College of Engineering for Women, India
Published: October 2024

In network security, safeguarding digital cyberspace infrastructure against malicious intrusions remains a paramount concern. This study addresses this imperative by proposing a novel approach that integrates digital watermarking, Huffman coding, and sophisticated attack classification techniques within the Controller Area Network (CAN) protocol framework. The proliferation of interconnected systems and the increasing sophistication of cyber threats necessitate novel strategies to fortify network defenses and ensure resilience in the face of adversarial activities. The research problem revolves around the need to develop an effective method for detecting and categorizing reconnaissance and violent attacks within cyberspace networks, particularly those utilizing the CAN protocol. Despite advancements in security protocols and intrusion detection systems, existing methodologies often fall short in accurately distinguishing between benign and malicious network activities, leaving critical infrastructure vulnerable to exploitation. This research uses digital watermarking to embed metadata within network packets, Huffman coding for efficient data compression, and advanced attack classification algorithms for real-time threat identification. The experimental results demonstrate the efficacy of the proposed approach in accurately differentiating between reconnaissance probes and violent attacks, thereby enabling timely and targeted responses to mitigate security threats.
Reflexiones sobre el rol del manejo poscosecha en la reducción de las pérdidas de alimentos y la inseguridad alimentaria
Authors: García Muñoz María Cristina , Aya Rodríguez Jorge Eduardo
Published: October 2024

¿Cómo se soluciona un problema si no se acometen las causas que lo generan? La pérdida de alimentos produce efectos económicos y ambientales que agudizan la inseguridad alimentaria y nutricional en el corto, mediano y largo plazo. Si los alimentos producidos no cumplen su fin último de satisfacer los requerimientos energéticos y nutricionales de la población, los recursos empleados para su producción se pierden, se incrementa la presión sobre la frontera agrícola y se generan gases de efecto invernadero innecesarios y de magnitud proporcional a la distancia que los separa de los centros de consumo. De otra parte, los productores reciben menores ingresos, mientras que los consumidores tienen que pagar más por los alimentos, lo cual reduce en ambos casos el acceso a estos. Estas condiciones ponen en riesgo la sostenibilidad de los sistemas agroalimentarios y la seguridad alimentaria y nutricional de la población. De acuerdo con lo anterior, es imperativo trabajar en la identificación de las causas de las pérdidas para plantear alternativas robustas, soportadas en la articulación entre los actores de la cadena de abastecimiento, promover sinergias intersectoriales y la inversión del sector privado y público en infraestructura, fortalecer las capacidades del capital humano y ajustar las normativas y las políticas públicas.