bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Immune‐enhancing Effects of Ibuprofen in an Immunodeficiency Model
Authors: Jorizzo Joseph L. , Goldblum Randall M. , Daniels Jerry C. , Ichikawa Yukinobu , Langford Marlyn P. , Fagan Karis M.
Published: May 2007

ABSTRACT: Three children and one adult with chronic mucocutaneous candidosis with documented deficient cellular immunity to Candida antigen were evaluated as a model to study the specific cellular immune‐enhancing potential of the prostaglandin synthetase inhibitor ibuprofen. Oral ibuprofen failed to have any consistent effect during sequential 4‐week on and off cycles on the following parameters: delayed hypersensitivity skin testing; lymphocyte transformation to Candida antigen; T‐cell subsets as determined by monoclonal antibody techniques; production of human immune interferon in response to staphylococcal enterotoxin A (SEA). Two patients showed a trend toward enhanced lymphocyte transformation to PHA while taking ibuprofen. In two patients who were studied 8–10 weeks after discontinuation of oral ketoconazole therapy, clinical recurrence of CMC was not prevented by oral ibuprofen therapy.
Dermatitis Artefacta
Authors: Van Moffaert M. , Vermander F. , Kint A.
Published: May 2007

ABSTRACT: Self‐inflicted dermatoses mainly refer to psychiatric disturbances such as psychoses, mental retardation, and personality disorders. Diagnostic clues are found in the nature and the evolution of the lesions as well as in the ambivalent combination of dependency on doctors and hostility toward them revealed in the patient's medical history. Management of dermatitis artefacta patients means dealing with the complex emotional isue of a basic antagonism in the dermatologist‐patient relationship. Both the dermatologist and the dermatologic nursing staff should show an understanding and nonaggressive attitude.
Serum IgE Antibodies to the Scabies Mite
Authors: Dahl Jens Christensen , Scwartz Bente , Graudal Charlotte , Christophersen Jette , Henrisken Svend Aage
Published: May 2007

ABSTRACT: Porcine scabies, mites, Sarcoptes scabiei var. suis are more readily available in sufficient quantities than are human scabies mites. Circulating IgE antibodies specific to porcine scabies mites were found in 6 (30%) of 20 scabies patients with an RAST score of at least 2. Seven patients had elevated serum total IgE levels. Correlation between the RAST values, the duration of pruritus, and the IgE levels was not found. The results do not prove the existence of antibodies specific to porcine scabies mites but strongly support this assumption.
Epidermolysis Bullosa
Authors: Haber Richard M. , Ramsy Colin A , Boxall Lionel B. H.
Published: May 2007

ABSTRACT: Nineteen patients with a ariety of types of epidermolysis bullosa were initially assessed in an open study of a treatment regime for the genetic type of epidermolysis bullosa. Nine of the ten patients admitted to the hospital for treatment showed definite objective improvement with decreased number of blisters and increased rate of healing of blisters. The mean percentage decrease in blister numbers from the time of admission until discharge from hospital was 76%. Sixteen patients were followed as outpatients for 5–11 months. Two patients continued to show objective improvement, while eight reported more rapid healing of their blisters. Six patients failed to improve. This treatment has beneficial effect in inpatients with epidermolysis bullosa. The improvement may be due to the intense topical treatment rather than to a specific item of the therapy. In the long term, this treatment has little effect on the formation of new blisters, but an accelerated healing of blisters is reported by 50% of the patients.
Bazex Syndrome
Authors: Mehta V. R. , Potdar R.
Published: May 2007

ABSTRACT: A dominant inheritance leading to development of nevoid basal cell epitheliomas on the face and follicular atrophoderma on the extremities constitute the two constant manifestations of Bazex syndrome. A patient with both manifestations on the trunk who fulfilled all the criteria for a diagnosis of nevoid basal cell epitheliomas is described. Histopathology of the basal cell cancer corresponded to that of the fibroepithelial tumor, thus differing from the more common nodular and trichoepitheliomatous presentations. Difficulty in associating the atrophoderma with a hair follicle (histologically) arises because the latter ceases to exist as a functional unit.
Dermatomyositis and Cancer in Singapore
Authors: Chan H. L.
Published: May 2007

ABSTRACT: Of 12 patients with adult dermatomyositis studied, 5 (41%) had associated malignancies, of which 3 were nasopharyngeal carcinomas. The youngest was a 23‐year‐old woman. In view of the high incidence of cancer and the predominance of nasopharyngeal carcinoma, malignacy evaluation in Chinese patients from the Far East, 20 years of age or older with dermatomyositis should have extended workups for postnasal cancer. Two patients who had positive antinuclear not have associated cancers. Three patients died of acute myocardial infarction.
Anti‐Androgens in Treatment of Acne Vulgaris
Authors: Amer Mohamed , Ramadan Ali , Monem Ahmed Abdel
Published: May 2007

ABSTRACT: Seventy‐five women suffering from acne vulgaris classified into three groups according to the grade of the disease. Anti‐androgenic tablets cyproterone acetate (CPA), were given in three cycles. The total number of patients whose condition improved was 52% after the first cycle, 55% after the second cycle, and 81.3% after the third cycle. No serious side effects were encountered. CPA is a suitable therapeutic modility for AV in women who use contraceptives.
Cryotherapy Versus Podophyllin in the Treatment of Genital Warts
Authors: Bashi Sami Anwer
Published: May 2007

ABSTRACT: 572 patients with solitary or multiple genital warts attending the Department of Genitourinary Medicine at the Royal Victoria Hospital, Bournemouth, U.K. between January 1981 and December 1981 were allocated to either podophyllin or cryotherapy for the treatment of their warts. Of 350 patients successfully treated for their warts and returned for a follow‐up examination 6 weeks or more after completing their treatment, 206 (139 men and 67 women) were treated with podophyllin, and 144 (86 men and 58 women) with cryotherapy. One hundred five (51%) of those treated with podophyllin and 114 (79%) treated with cryotherapy were free of warts at their follow‐up examination. Patients treated with podophyllin required a mean of 6.7 ±SD 3.5 treatements over a mean of 4.7 ± SD 2.4 weeks, whereas those receiving cryotherapy required a mean of 2.6 ± SD 2.0 applications over a mean of 2.3 ± SD 1.2 weeks.
Linear IgA Bullous Dermatosis
Authors: Wilson B. Dale , Beutner Ernst H. , Kumar Vijay , Chorzelski Tadeusz P. , Jablonska Stefania
Published: May 2007

ABSTRACT: Linear IgA bullous dermatosis (LABD) can mimic bullous pemphigoid (BP) and/or dermatitis herpetiformis (DH) both clinically and histologically. LABD, however, can be distinguished from BP and DH by direct immunofluorescent (IF) demonstration of linear IgA deposits along the basement membrane zone. A retrospective study of 234 cases of BP, 27 cases of LABD, 60 cases of DH, and 20 cases of cicatricial pemphigoid (CP) revealed that BP patients are significantly older than LABD or DH patients and LABD patients are significantly older than DH patients. BP and CP occur more frequently in women (65‐70%) than LABD or DH (44–48%). The frequencies of C3 deposits in the basement membrane zone (BMZ) are significantly higher in BP (85%) compared with LABD (18.5%) and DH (28.3%). LABD patients varied in their response to various therapeutic agents. Some responded to corticosteroids and some to sulfones alone, whereas others required a combination of corticosteroids and sulfones.
Trichostasis Spinulosa
Authors: Young Margaret C. , Jorizzo Joseph L. , Sanchez Ramon L. , Hebert Adelaide A. , Thomas Danny R. , King Clinton A.
Published: May 2007

ABSTRACT: Trichostasis spinulosa is a common disorder of follicular hyperkeratosis that is often confused clinically with similar disorders, such as keratosis pilaris and eruptive vellus hair cysts. Six patients from the UTMB dermatology clinic who had trichostasis spinulosa are presented. Two of the six also had keratosis pilaris and one had eruptive vellus hair cysts. The present study was undertaken to compare and contrast the clinical presentation and histopathologic appearance of these three disorders. The results of the study and review of the literature revealed differences in distribution of lesions and microscopic appearance of follicular and histopathologic material.
The Efficacy of Permethrin Lotion in Pediculosis Capitis
Authors: Mazas E. Ares , Porto M. Casal , Perez M. C. Sela , Farquhar J. A. , Hutchinson D. B. A.
Published: May 2007

ABSTRACT: A clinical trial of the pyrethroid permethrin in 1% lotion was performed on 20 children. Ten were treated for 10 minutes and 10 for 2 hours. All lice washed off the heads of children treated for 2 hours were dead immediately after treatment. Twenty‐four percent of the lice removed from one child treated for 10 minutes were still alive 2 hours later. The ovicidal effect was similar in both groups, with egg mortality 88% and 90% following 10‐minute and 2‐hour treatment, respectively. The mortality of untreated control eggs was 14% and 11%, respectively.
Frey's Syndrome
Authors: Harper Kenneth E. , Spielvogel Richard L.
Published: May 2007

ABSTRACT: Frey's syndrome is a form of gustatory hyperhidrosis that develops following surgery, trauma, or disease of the parotid gland area. Several theories have been proposed to explain the resulting symptomatology. Treatment often is difficult or ineffective. An unusual case is presented involving a patient with delayed onset of symptoms who responded well to topical application of 20% aluminum chloride in an‐hydrous ethyl alcohol.
Granulation Tissue Proliferation During Isotretinoin Treatment
Authors: Puig Lluis , Moreno Abelardo , Llistosella Enric , Noguera Xavier , de Moragas J. M.
Published: May 2007

ABSTRACT: Excessive. pseudotumoral granulation tissue proliferations appeared in three patients receiving isotretinoin for nodulocystic acne. A review of the literature disclosed few reports of this unusual adverse reaction. Two clinical patterns have been reported; one in a periungual location and the other occurring in the sites of acne lesions during isotretinoin therapy. Loose edematous connective tissue with small vessels and chronic inflammatory infiltrate were the histologic findings in all three cases.
Book Reviews
Authors: BEERMAN HERMAN
Published: May 2007

DERMATOLOGIC IMMUNOLOGY AND ALLERGY. Julius Stone, ed.

1984 YEARBOOK OF DERMATOLOGY. Arthur J. Sober and Thomas B. Fitzpatrick.

DIFFERENTIAL DIAGNOSIS OF ORAL MUCOUS MEMBRANE LESIONS. L. Ashamallah.

CURRENT TOPICS IN PATHOLOGY: DERMATOPATHOLOGY. C. L. Berry, E. Crundmann, and W. H. Kirsten.

THE DIAGNOSIS AND MANAGEMENT OF EARLY LEPROSY. Stanley G. Browne.
Cephalosporins in Cutaneous Infections
Authors: Parish Lawrence Charles , Witkowski Joseph A. , Snow Rodney , Eron Lawrence , Mogabgab William J.
Published: May 2007

ABSTRACT: The safety and efficacy of ceftazidime administered as 0.5 g every 8 hours (q8h) or 1.0 g q8h for at least 5 days were compared in 197 patients and found to be effective in the treatment of cellulitis. abscesses, skin ulcers, and wound infections. Staphylococcus aureus was the predominant pathogen in both treatment groups with approximately half of the isolates from each treatment group being gram‐positive. Pseudomonas aeruginosa was the most common gram‐negative isolate. P. aeruginosa, Proteus mirabilis, and Escherichia coli each comprised 5–12% of the isolates from each treatment group. Clinical cure or improvement was achieved in 98.7% of the patients in each treatment group. Concurrently with clinically successful treatment, a high rate of bacteriologic eradication without superinfection was achieved with the 0.5‐g regimen (84% of all isolates) and the 1.0‐g regimen (92%).
Fulminant Cutaneous T‐cell Lymphoma and Sézary Syndrome
Authors: Lang Ruth , Bernheim Joel , Bar‐Sela Sari , Joseph Dina , Ravid Mordchai
Published: May 2007

ABSTRACT: The term cutaneous T‐tell lymphoma (CTCL) has recently been coined to describe a group of rare lymphoproliferative T‐cell disorders classically beginning in the skin and pursuing a chronic, progressive, and indolent course eventually followed by visceral involvement. This term encompasses the spectrum of the traditional mycosis fungoides and Sézary syndrome. A unique case of CTCL that developed a fulminant course leading to death within a few months following the initial symptoms is presented. The clinical course bears a striking similarity to a group of acute T‐cell malignancies, while the cytologic‐pathologic findings favor the diagnosis of Sźary syndrome. Regardless ot the exact classifications, this entity appears to be a highly malignant T‐cell disorder, resistant to chemotherapy.
Premycotic Poikiloderma, Mycosis Fungoides and Cutaneous Squamous Cell Carcinoma
Authors: Colver Graham , Mortimer Peter , Dawber Rodney
Published: May 2007

ABSTRACT: Two patients with premycotic poikiloderma developed one squamous cell carcinoma each. A review of the literature reveals 28 reported cases of this association, but in 26 of these the patient had been exposed to carcinogens. Our patients had no history of exposure to carcinogenic agents. In both our cases, the squamous carcinomas behaved aggressively. The possible relationship with the poikiloderma is discussed.
Eruptive Vellus Hair Cyst
Authors: Hornstein Edmund , Wilcox Carver , Oberlies Dennis , Schott Weldon , Hayne Steven
Published: May 2007

Eruptive vellus hair cysts (EVHC), first described by Esterly et al. in 1977, present as asymptomatic aggregations of one to four discrete papules, each measuring up to 2 mm.1 These lesions are pigmented and range in color from red‐brown to grey‐black. They are found most commonly on the chest, though they also have been reported on the forearms, thighs, popliteal fossae, forehead, and eyelids.

The etiology of EVHC is unknown but may represent an abnormality of the development of vellus hair follicles. This condition does not appear to show a predilection toward either sex, and an autosomal dominant pattern of inheritance has been postulated.2 Arising spontaneously, the lesions are usually found in the young‐to‐middle‐aged patient. Though EVHC have not been responsive to oral vitamin A therapy or keratolytic agents; the cyst may resolve spontaneously in some patients. One author3 suggests this may occur via transepithelial elimination, while another author4 postulates that their resolution is due to an intracutaneous foreign body reaction.

Histologic examination reveals that the cysts are found in the middermis. They are lined by several layers of squamous epithelium and contain laminated keratinous material. Vellus hair shafts may be seen within the confines of the cyst at various planes of the section. There often is a rudimentary follicle associated with the wall of the cyst. Vellus hairs, best seen under polarized light, are characteristic of this condition. Unless the integrity of the cyst wall has been violated, there is no evidence of inflammation.
Cryotherapy in Acute Cutaneous Leishmaniasis
Authors: Leibovici Veka , Aram Homayoun
Published: May 2007

ABSTRACT: Fourteen patients with acute cutaneous leishmaniasis entered a study testing the efficacy of liquid nitrogen. All lesions were cured clinically and prntozoologically within 3–8 weeks, without noticeable scarring. The patients did not experience adverse side effects, and there was no relapse 4 months after cessation of therapy. The results of this study indicate that cryotherapy is a safe and effective method for treating cutaneous leishmaniasis.
Candida Folliculitis in Heroin Addicts
Authors: Leclerc Georgette , Weber Max , Contet‐Audonneau Nelly , Beurey Jean
Published: May 2007

ABSTRACT: Three heroin addicts had Candida folliculitis of the scalp, beard, and pubis associated with fever, chills, headache, and fatigue. In each case, pseudohyphae were found within a hair and yeasts around it and Candida was recovered from urine. These facts support a systemic dissemination. Since serious ocular and osteoarticular lesions have been described with this type of skin lesion, prompt diagnosis may be important to initiate treatment and prevent sequelae.
Pure Cutaneous Histiocytosis X
Authors: Magaña‐García Mario
Published: May 2007

ABSTRACT: A 38‐month‐old boy presented with nodules in the skin of the genital region present for 21/2 years. These later spread to the skin of the trunk, head, and extremities. A complete clinical workup could not reveal involvement in any other organ sites and biopsy of one of the cutaneous lesions was diagnosed as histiocytosis X. Because the child was in generally good condition, no treatment was given. Follow‐up revealed that the disease had remained limited to the skin, where 15% of the lesions disappeared spontaneously.
Deep Granuloma Annulare in Adults
Authors: Salomon Richard J. , Gardepe Sharon F. , Woodlfy David T.
Published: May 2007

ABSTRACT: Subcutaneous nodules with the histopathologic features of rheumatoid nodules can occur in both rheumatic and nonrheumatic diseases. When there is no evidence of systemic disease, they often are classified as deep granuloma annulare. While there are numerous reports of such nodules occurring in children without systemic disease, there are few reports of similarly affected adults. Two adults are described with multiple subcutaneous nodules that were overlying joints and were histologically similar to rheumatoid nodules. Neither patient had other clinical or laboratory manifestations of rheumatic disease. These cases most likely represent an adult from of deep granuloma annulare. The wide clinical spectrum in which similar nodules can occur and their pathogenesis, is discussed.
Book Reviews
Authors: BEERMAN HERMAN
Published: May 2007

METHODS IN SKIN RESEARCH. D. Skerrow and C. J. Skerrow

DISEASES OF THE HAIR AND THE SCALP. L. Bartosova, V. Jorda, and Z. Stava

THE PHARMACOLOGICAL BASIS OF THERAPEUTICS. Alfred Goodman Gilman, Louis S. Gordon, Theodore W. Rail, and Ferid Murad

PORTRAIT OF A ZOO. Robert and Anne Warin

THE AUTHOR AND HIS AUDIENCE.

TWO HUNDRED YEARS OF PUBLISHING. R. Kenneth Bussy

PHILADELPHIA S PUBLISHERS AND PRINTERS: AN INFORMAL HISTORY. R. Kenneth Bussy

DERMATOLOGIA NELLA PRATICA CLINICA (IN ITALIAN). Antonio Tosti

ENFERMEDADES DE LA BOCA: SEMIOLOGIA, PATOLO‐CIA, CLINICA Y TERAPEUTICA DE LA MUCOSA BUCAL. David A. Crinspan

INTERPRETATION OF IMMUNOFLUORESCENT PATTERNS IN SKIN DISEASE. R. Valenzuela, W. F. Bergfeld, and S. Deodhar

DERMATOLOGY. Samuel L. Moschella, M.D. and Harry J. Hurley, M.D.

MODELS IN DERMATOLOGY: DERMATOLOGY. 374 pages. MODELS IN DERMATOLOGY: DERMATOPHARMACOLOGY AND TOXICOLOGY. 370 pages. H. I. Maibach and N. J. Lowe

REGIONAL DERMATOLOGY: A SYSTEM OE DIAGNOSIS. Ervin Epstein, M.D.

TRAITE DE MYCOLOGIE MEDICALE (IN FRENCH). D. Grigoriu, J. Delacretaz, and D. Borelli
Pemphigus With Characteristics of Dermatitis Herpetiformis
Authors: Ingber Arieh , Feuerman Eleasar J.
Published: May 2007

ABSTRACT: Five patients had a form of pemphigus which in its early stages resembled dermatitis herpetiform, although the immunofluorescent findings were typical of pemphigus, Potassium iodide tests, performed for the first time In such patients, showed positive results in two patients. Follow‐ups ranging from 5 to 14 years have shown a benign course with low to absent dosages of steroids
Effects of Solcoderm
Authors: Engelberg Isaac S. , Ronnen Meyer , Suster Saul , Schewach‐Millet Miriam , Stempler D. , Schibi‐Brilliant Ginnette
Published: May 2007

ABSTRACT: The effects of treatment and depths of penetration of a 5–fluorouracil and salicylic acid preparation (Solcoderm) were studied in 24 patients treated for basal cell carcinoma with this compound. Two thirds of the patients in our study showed islands of residual tumor in the dermis following treatment, whereas total disappearance of the tumor was observed in one third. The depth of the fibrotic changes induced by the drug varied from 0.34 to 0.40 cm for the morphea type of basal cell carcinoma and from 0.52 to 0.88 cm for the conventional types. It is recommended that treatment with this compound be reserved only for superficial basal cell carcinomas and that it be avoided altogether in basal cell carcinoma of the morphea type.
Partial Wound Closure Combined with Marsupialization for Repair of Selected Cutaneous Surgical Defects
Authors: Lewis John E.
Published: May 2007

ABSTRACT: A useful technique for the management of selected surgical defects that cannot he primarily closed in their entirety is presented.
Photodermatoses in Lagos
Authors: Olumide Yetunde Mercy
Published: May 2007

ABSTRACT: Light‐sensitive dermatoses do not constitute a major problem among the black people in Nigeria. In a 10‐year study, only 64 cases (about 0.4% of all dermatologic patients) had light‐sensitive dermatoses. Seven of the JO patients with endogenous photodermatoses were albinos. Two patients with polymorphic light eruption were visiting Caucasians. Only one normally pigmented black Nigerian had xeroderma pigmentosum. Fifty‐four patients bad photodermatoses from exogenous causes, of which hydroquinone‐induced exogenous ochronosis constituted the largest group of patients. Two women had estrogen‐induced porphyria cutanea tarda.
Systemic Candidiasis in Heroin Abusers Cutaneous Findings
Authors: Bielsa I. , Miro J. M. , Herrero C. , Martin E. , Latorre X. , Mascaro J. M.
Published: May 2007

ABSTRACT: Systemic candidiasis in intravenous drug abusers (IVDA) is a new syndrome caused by Candida albicans and characterized by the sequential development of skin, eye, and osteoarticular lesions, which together form a typical clinical picture. We studied 30 patients with suggestive skin lesions: papules, nodules, and pustules in hair‐bearing areas, particularly the scalp and beard area, associated with hair invasion by candiadal hyphae.

Ocular and osteoarticular involvement and presence of candidemia in some of the patients suggested blood‐borne colonization of C. albicans. The infection has been related to “brown” heroin. The origin of C. albicans and the reasons for its exclusive localization in the skin and these organs are discussed The characteristic clinical picture is widely different from that of classic disseminated candidiasis in immunodeficient patients. Therapy is also discussed.
Acute Febrile Mucocutaneous Lymph Node (Kawasaki) Syndrome
Authors: Velez‐Torres Rafael , Callen Jeffrey P.
Published: May 2007

ABSTRACT: Twenty‐five cases of Kawasaki syndrome were seen over a 6‐yoar period at Children's Hospital in Louisville, Kentucky. The diagnosis of Kawasaki Syndrome was established in all cases by use of the criteria developed at the Center for Disease Control (CDC). The medical files of these cases were systematically reviewed for epidemiologic, clinical, laboratory, and therapeutic features. The results of this study were comparable to findings from previously reported series. In contrast to previous data, we found several cases in which the febrile illness was associated with a viral infection. Two children developed coronary aneurysms, but there were no deaths, and resolution of the aneurysm occurred in one of the patients. There were no clustering of cases and no unusual epidemiologic findings; none of the patients had a recurrence. Patients with Kawasaki syndrome should be followed closely during both the acute febrile and the convalescent phases. Similar conditions in a child with a fever and a rash need to be excluded.
The Substitution of Glucose‐Antiglucose Oxidase Complex (GAG) for Peroxidase‐Antiperoxidase (PAP) in Immunohistochemical Studies of Skin
Authors: Elias Jules M. , Phillips Mildre E. , Boss Eleanor , Merot Yves , Mihm Martin C.
Published: May 2007

ABSTRACT: The substitution of glucose‐antiglucose oxidase complex (GAG) for peroxidase antiperoxidase (PAP) in the Sternberger three‐layer unlabeled antibody method avoids the problems associated with the use of the chromogen 3,3, diaminobenzidine (DAB). The blue final reaction product obtained using the GAG complex is not obscured by melanin granules, which is often the case when using the PAP‐DAB combination. The replacement of PAP with GAG complexes facilitates the detection of melanocytes in melanoma and blue nevi. The absence of endogenous glucose oxidase in mammals provides for greater image contrast, which is not possible using alternative chromogens and immunoperoxidase.
Progressive Systemic Sclerosis Occurring in Patients Exposed to Chemicals
Authors: Czirják L. , Dankó Katalin , Schlammadincer J. , Suranyi P. , Tamasi L. , Szecedi G. Y.
Published: May 2007

ABSTRACT: Eight patients with systemic sclerosis previously exposed to organic chemical agents were investigated. Laboratory and clinical data of these patients were evaluated. The interval between the beginning of exposition and symptoms was 6.1 ± 4.9 years. Considering the laboratory findings, a slight decrease in OKT4 positive T cell number was found. The antinucleolar and fine speckled antinuclear antibody pattern was found simultaneously in five cases. The possible role of chemical agents in the development of sclerodermic changes is discussed.
Cefuroxime Axetil in the Treatment of Cutaneous Infections
Authors: Parish Lawrence Charles , Cocchetto David M. , Werner Karen , Jungkind Donald L. , Witkowski Joseph
Published: May 2007

ABSTRACT: A multicenter clinical trial was conducted in 125 out‐patients with skin and skin structure infections due to bacteria in order to compare the safety and efficacy of cefuroxime axetil and cefaclor. Patients with a median age of 32 years were randomly allocated to treatment for 10 days with one of three treatments: cefuroxime axetil 250 mg b.i.d., cefuroxime axetil 500 mg b.i.d., or cefaclor 250 mg t.i.d. Clinical evaluations of each patient were done pre‐treatment, 2 to 4 days intra‐treatment, and within 3 days post‐treatment. One patient discontinued cefuroxime axetil due to severe urticaria and one patient discontinued cefaclor due to a persistent headache and vomiting. Cefuroxime axetil was an effective antibacterial agent for treatment of common skin infections. Clinically beneficial outcome was achieved for 92% (cefuroxime axetil 250 mg b.i.d.J, 95% (cefuroxime axetil 500 mg b.i.d.J, and 97% (cefaclor 250 mg t.i.d.J of patients. Since the study failed to demonstrate a significant advantage of higher dosage, cefuroxime axetil should be prescribed in a regimen of 250 mg twice a day for patients with skin infections.
Skin Manifestations in Infants With AIDS
Authors: Torre Donato , Sampietro Carmen , Paolo Fiori Giovanni , Dietz Alfredo , Montanari Mario
Published: May 2007

ABSTRACT: We have observed a peculiar skin manifestation that resembles cutis marmorata in three patients with AIDS and may be included among the several clinical aspects of AIDS in pediatric patients. One of the three patients died 4 month; after the diagnosis. In an another patient, the skin lesion is still present 2 years after appearance.
Generalized Pruritus as a Presenting Symptom in Nigeria
Authors: Olumide Yetunde Mercy , Oresanya Felix
Published: May 2007

ABSTRACT: In a retrospective study of 4000 consecutive dermatologic patients seen at the Lagos University Teaching Hospital Skin Clinic, 268 patients (6.7%) had generalized pruritus without obvious skin diseases. Filariasis was responsible for the pruritus in 57% of these patients; 21% was bath‐related pruritus, and the reasons for this were highlighted. In 6% of cases, pruritus was thought to be due to intolerance to environmental heat; 9.7% was due to miscellaneous causes. Pruritus from systemic diseases accounted for 3.7%. Causes for the pruritus were not elicited in 2.6% of the patients.
Pityriasis Rosea
Authors: Abdel‐Hafez Kamal , Deyab Zeinab
Published: May 2007

ABSTRACT: Some immunologic studies were carried out for 31 patients with pityriasis rosea. Normal levels of serum IgG and IgA but higher levels of IgM were obtained. Serum C3 values were decreased while C4 values were normal. B lymphocytes showed no difference from the controls, whereas T‐cell counts were significantly lower in the patients. The migration inhibition indices were higher in the patients than the controls. Direct immunofluorescence tests were negative in the studied three cases. The possible implication of a viral infection in the production of the reported changes was discussed.
Light and Electron Microscopic Studies of Pityriasis Rosea
Authors: El‐Shiemy S. , Nassar A. , Mokhtar M. , Mabrouk D.
Published: May 2007

ABSTRACT: Light and electron microscopic studies of biopsy specimens taken from five patients with pityriasis rosea revealed the most conspicuous finding to be the presence of dyskeratotic cells within the epidermis. Ultrastructurally. these cells contained an aggregation of tonofilaments, intracytoplasmic desmosomes, many vacuoles, and viral‐like particles. It is assumed that pityriasis rosea is caused by a virus to which these changes are related.
Electron Microscopic Observation on Infected Hairs of Kerion Caused by Microsporum nanum
Authors: Wenyan Zhu , Mingyu Xia , LI Huang , Shaoxi Wu , Qing Zhong , Bian Zhao
Published: May 2007

Microsporum nanum can afflict human hair, al‐though pigs are the usual focus of infection. Although this dermatophyte was thought to invade hair as an endothrix, electron microscopic studies show it to cause ectothrix infection due to its keratinolytic activities.
Effects of Nordihydroguaiaretic Acid, Phloretin, and Phloridzin on the Activity of Adenylate Cyclase, Lipoxygenase and Hexose Transport, and Growth of Cultured Keratinocytes
Authors: Wilkinson David I. , Orenberc Elaine K.
Published: May 2007

Compounds related to the flavonoid group of natural products may have potential as antipsoriatic drugs. The dihydrochalcone phloretin, its glycoside derivative phloridzin. and the structurally related compound nordihydroguaiaretic acid (NDCA) were selected for study, Phloretin and NDGA strongly inhibited keratinocyte growth hut had no effect on isoproterenol‐stimulated adenylate cyclase; phloridzin had no effect on growth hut potentiated the response of the enzyme. None had any effect on phosphodiesterase. Neither phloretin or phoridzin inhibited lipoxygenase or, surprisingly, decreased deoxyglucose transport. Phloretin and NDCA should he considered antipsoriatic agents.
An Appraisal of Epidemiologic, Clinical, Bacteriologic, Histopathologic, and Immunologic Parameters in Cutaneous Tuberculosis
Authors: Sehgal V. N. , Srivastava G. , Khurana V. K. , Sharma V. K. , Bhalla P. , Beohar P. C.
Published: May 2007

ABSTRACT: Cutaneous tuberculosis incidence was recorded as 0.15%. Of the 42 patients, 23 had scrofuloderma, 17 lupus vulgaris, and 2 tuberculosis verrucosa cutis. Both men and women were affected by the disease in the second and third decades. Its duration was variable. An affirmative family history was elicited in five scrofuloderma patients. The clinical expression largely conformed to the ritual text. Variation in Mantoux test positivity was unremarkable. The disparity in the demostration of bacilli in the smear and tissue sections was. however, quite apparent in scrofuloderma. The correlation of different parameters indicates a continuous spectrum, formed at one end by lupus vulgaris, and at another by scrofuloderma. A moderate to strongly positive Mantoux text, enormous lymphocytes in the granuloma, absence of tubercle bacilli, negative culture, and an apparently normal immunoprofile were features of lupus vulgaris; whereas scrofuloderma had a moderately positive Mantoux test, lesser number of lymphocytes in the granuloma, large number of bacilli in tissue smear and/or tissue section, raised levels of immunoglobulins, and a grossly lowered C3 levels. The other variants probably occupy a position in between.
Improvement of Chronic Neurotic Excoriations With Oral Doxepin Therapy
Authors: Harris Brian A. , Sherertz Elizabeth F. , Flowers Franklin P.
Published: May 2007

ABSTRACT: Two patients with 6‐ to 7‐year histories of neurotic excoriations refractory to the usual dermatologic management were referred for evaluation. Both had symptoms and signs of depression associated with the onset and persistence of the skin condition. Doxepin, a tricyclic antidepressant therapy with potent antihistamine properties, was used in oral doses of 30–75 mg daily for our patients. This therapy resulted in symptomatic and clinical improvement in both patients within several weeks. This limited report of apparent benefit of doxepin in two patients with neurotic excoriations and depression offers a potential therapy in the management of this challenging clinical problem.
Cutaneous Onchocerciasis
Authors: Maso Martha J. , Kapila Rajendra , Schwartz Roberta A. , Wiltz Hector , Kaminski Zigmund C. , Lambert W. Clark
Published: May 2007

ABSTRACT: Onchocerciasis was diagnosed when a skin biopsy specimen immersed in saline revealed microfiliariae. The patient was a 22‐year‐old student from Cameroon, West Africa, complaining of small, recurrent, pruritic papules on his thighs. Chemotherapy with ivermectin, an established anti‐parasitic agent with newly recognized anti‐onchocercal potential, was well tolerated, and microfilariae were not detected in post‐therapy skin biopsy specimens. The diagnosis of Onchocerciasis should be entertained in individuals returning or emigrating from endemic areas.
Malignant Pyoderma
Authors: Novice Fred M. , Hacker Peter , Unger Walter P. , Keystone Edward C.
Published: May 2007

ABSTRACT: A patient with malignant pyoderma brought into complete remission with immunosuppressive cyclophosphamide treatment after the failure of multiple other therapies is reported. The entity of malignant pyoderma with its clinical characteristics, laboratory and biopsy findings, complications, and modalities of therapy is reviewed.
Deep Mycoses in Amazon Region
Authors: Talhari Sinésio , Cunha Maria da Graca Souza , Schettini Antonio Pedro Mendes , Talhari Anette C.
Published: May 2007

ABSTRACT Patients with deep mycoses diagnosed in dermatologic clinics of Manaus (state of Amazonas, Brazil) were studied from November 1973 to December 1983. They came from the Brazilian states of Amazonas, Pará, Acre, and Rondônia and the Federal Territory of Roraima. All of these regions, with the exception of Pará, are situated in the western part of the Amazon Basin. The climatic conditions in this region are almost the same: tropical forest, high rainfall, and mean annual temperature of 26C. The deep mycoses diagnosed, in order of frequency, were lorge Lobo's disease, para‐coccidioidomycosis, chromomycosis, sporotrichosis, mycetoma, cryptococcosis, zygomycosis, and histoplasmosis.
Self‐Limiting Acrodermatitis Enteropathica
Authors: Sharma N. L. , Sharma R. C. , Gupta K. R. , Sharma R. P.
Published: May 2007

ABSTRACT A variant of acrodermatitis enteropathica is described that has its onset before weaning and clears when the child starts its normal solid diet. A pedigree with three interrelated families is reported where 10 children were afflicted with this variant. They had symptoms of hypozincemia for a brief period during infancy. At the time of this study, they were symptom‐free and their serum zinc levels were found to be within normal limits. The term “self‐limiting acrodermatitis enteropathica” is proposed for the variant. In one lactating mother, the mammary zinc secretion was determined and was found to be deficient and unresponsive to oral zinc supplements. The possible mode of inheritance is also discussed.
Atrophoderma (Pasini‐Pierini)
Authors: Berman Alexander , Berman Gary D. , Winkelmann Richard K.
Published: May 2007

ABSTRACT A patient with atrophoderma (Pasini‐Pierini) was studied. Microscopic examination showed small collections of mononuclear cells around dermal blood vessels. Electron microscopic study demonstrated macrophages and lymphocytes around vessels and between fibers in the dermis; the epidermis, dermis, collagen, and elastic fibers appeared normal. Monoclonal antibody studies of the cells in the perivascular infiltrate demonstrated cells reacting with anti‐Leu‐1 (pan‐T‐cell antibody), anti‐Leu‐3a (the helper/inducer T‐cell antibody), and OKM 1 antibody‐reacting cells (macrophages). Direct, immunofluorescent studies showed IgM and C3 staining in the small blood vessels of the papillary dermis, scattered IgM cytoids at the basement membrane, and focal fibrinogen in the mid‐dermis.

Mononuclear cells in the perivascular infiltrate, similar in type and percentage concentration, have been demonstrated also in patients with anetoderma, another rare atrophic cutaneous disorder. Macrophages and T lymphocytes around papillary dermal blood vessels may play a role in the pathogenesis of atrophoderma and anetoderma.
Unilateral Pterygium Inversum Unguis
Authors: Morimoto Sandra S. , Gurevitch Arnold W.
Published: May 2007

ABSTRACT Pterygium inversum unguis is a nail abnormality in which the distal aspect of the nail bed/hyponychium is adherent to the ventral surface of the nail plate, resulting in obliteration of the distal groove. We present a 50‐year‐old man who developed this abnormality on his right fingers and toes after a stroke that resulted in paresis of his right side. Unusual features of this case include the association with a neurologic disorder, assymetric distribution, involvement of toes as well as fingers, and occurrence in the male gender.
Koilonychia of the Toenails in Children
Authors: Yinnon A. M. , Matalon A.
Published: May 2007

ABSTRACT: Two hundred twenty‐four children were examined for koilonychia of the toenails. Koilonychia was encountered in 55 out of 171 (32%) kibbutz children compared with 9 out of 53 (17%) of urban children (p < 0.046). The most likely explanation for the increased prevalence of koilonychia in kibbutz children is habitual minor trauma associated with barefoot walking and frequent water immersion.
Acquired Pachydermatoglyphy A Cutaneous Sign of Internal Malignancy
Authors: Pujol R. M. , Puig L. , Garcia‐Marques J. M. , De Moragas J. M.
Published: May 2007

ABSTRACT: A 70‐year‐old man with hypertrophic osteoar‐tropathy secondary to a squamous cell carcinoma of the lung presented a distinctive pattern of late‐onset bilateral palmar keratoderma. A yellowish rugose appearance with accentuation of normal ridges and sulci (pachydermatoglyphy) involving the palms was observed. The differential diagnosis and the clinical relevance of acquired pachydermatoglyphy as a cutaneous marker of internal malignancy are discussed.
Deep Dermatophytosis to Trichophyton rubrum and T. verrucosum in an Immunosuppressed Patient
Authors: Lestringant Gilles G. , Lindley Sheldon K. , Hillsdon‐Smith Jeremy , Bouix Gerard
Published: May 2007

ABSTRACT: A patient treated with immunosuppressant drug therapy for a non‐Hodgkin's lymphoma and who presented with a tinea corporis developed a sudden outbreak of numerous subcutaneous nodules. Deep‐seated hyphae and spores were found in skin biopsy specimens. There was no evidence of keratin debris or histologic features of granulomata and giant cells. Cultures from tinea and nodules grew Trichophyton rubrum and T. verrucosum. There are no more than 60 cases of deep dermatophytosis reported in the literature.
Immunologic Studies in Darier's Disease
Authors: Halevy S. , Weltfriend S. , Pick A. I. , Weiss H. , Duczyminer‐Kahana M. , Sandbank M.
Published: May 2007

ABSTRACT: Humoral and cellular immunity were evaluated in 10 patients with Darier's disease. The mean levels of serum immunoglobulins, serum complement, peripheral macro‐phages, and peripheral B and T lymphocytes were within normal limits. Secretory IgA was present in all patients studied. Skin tests for delayed hypersensitivity revealed complete anergy in one of the eight patients tested. Lymphocyte transformation tests revealed statistically significant enhanced responsiveness to both PHA and ConA mitogens in several concentrations studied. These findings may suggest either the existence of alterations in immunoregulation of lymphocyte subpopulations in Darier's disease or may be limited to alterations in membrane functions of certain lymphocyte subpopulations which can be detected only in vitro. The role that such immunologic aberrations may play in the pathogenesis of Darier's disease is still obscure.
Treatment of Cutaneous Infections Worldwide Experience with Ciprofloxacin
Authors: Parish Lawrence Charles , Witkowski Joseph A. , Junckind Donald L. , Asper Ronald F.
Published: May 2007

ABSTRACT: Oral ciprofloxacin, a new fluorinated 4‐quino‐lone, was evaluated in 795 patients with skin and skin structure infections. Ninety‐four point one percent of the patients treated had clinical success with eradication of almost all of the offending bacteria. Ciprofloxacin has good activity against gram‐positive organisms and excellent activity against gram‐negative organisms. Side effects were few and not considered significant.
Disseminated Sporotrichosis
Authors: Schamroth J. M. , Grieve T. P. , Kellen P.
Published: May 2007

ABSTRACT: The clinical manifestations of sporotrichosis can be classified into three disease patterns: (1) localized lymphatic sporotrichosis, (2) fixed cutaneous (or endemic) sporotrichosis, and (3) disseminated sporotrichosis. This presentation reflects a rare disseminated form of the disease with extensive cutaneous and systemic lesions, and further illustrates the difficulty in diagnosing systemic sporotrichosis infection.
Orf and Pregnancy
Authors: Taieb Alain , Guillot Martin , Carlotti Didier , Maleville Jean
Published: May 2007

ABSTRACT: A 31‐year‐old woman presented with orf on the forefingers at 34 weeks of gestation. The disease, contracted after handling sheep a week before, was uncomplicated, and the patient gave birth at term to a normal baby. Although some cases with features suggestive of viremic spread had been described, the authors find an overall benign picture of orf in man and recommend symptomatic therapeutic measures.
Erosion of Psoriatic Plaques After Chronic Methotrexate Administration
Authors: Kaplan David L. , Olsen Elise A.
Published: May 2007

ABSTRACT: A 43‐year‐old while man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate. This unusual cutaneous sign may be the first sign of methotrexate toxicity.
Pattern of Epidemics of Donovanosis in the “Nonendemic” Region
Authors: Sehcal Virendra N. , Jain M. K.
Published: May 2007

ABSTRACT: Of the 432 genital ulcer cases seen in 1985, 36 had donovanosis, thus forming an incidence of 8.33%. In contrast, 42 (6.38%) cases of donovanosis were diagnosed among a total of 658 cases of genital ulcers in 1983. The majority of patients in both epidemics were young unmarried men who contracted the disease through extramarital sexual intercourse. Perianal lesions were seen primarily in those who had a history of sodomy. The disease chiefly affected illiterate persons of low socioeconomic strata. The incubation period varied from 1 to 90 days. Twenty (62.50%) patients in the 1985 epidemic had an incubation period of less than 7 days, in contrast to only 9 (34.61%) in the 1983 epidemic. The epidemics occurred from autumn to the start of winter. Duration of the disease varied from 1 day to 6 years. The clinical features and sites of afflication were usual; however, pseudo‐bubo and pseudoelephantiasis0 were conspicuous in a significant minority.
Fibroblasts in Dermal Tissue Repair
Authors: Bouissou H. , Pieraggi M. , Julian M , Uhart D. , Kokolo J
Published: May 2007

ABSTRACT: The cellular dynamics of dermal regeneration were studied in nonsutured cutaneous wounds of female pigs and monkeys with electron microscopy and immunohistochemistry to demonstrate the origin and the development of fibroblasts forming granulation tissue. The results indicate that fibroblasts do not originate from histiocytes but from resting fibroblasts in the wound margins. These resting fibroblasts first become undifferentiated mesenchymal cells termed “X” cells. The “X” cells then multiply, migrate, and invade the wound defect in approximately 3 days, transforming into highly active fibroblasts. The active fibroblasts are endowed with the capacity of further transformation to fibroclasts and myofibroblasts. The latter two cell populations then effectively cause remodeling of newly formed tissue and contraction of wound margins.
Hyperpigmentation in Megaloblastic Anemia
Authors: Lee Seung Hun , Lee Won Soo , Whang Kyu Chuan , Lee Sun Ju , Chung Jae Bock
Published: May 2007

ABSTRACT: Hyperpigmentation of the hands and feet developed in a 65–year–old Korean woman who had undergone a total gastrectomy and esophagojejunostomy due to early gastric cancer 7 years previously. A diagnosis of megaloblastic anemia due to vitamin B12deficiency was made. In the areas of pigmentation, there were abnormally large nuclei in the keratinocytes. All of these findings were reversible upon the administration of vitamin B12 Ultrastructurally, there were many intracytoplasmic desmosomes, numerous aggregated bundles of tonofilaments, and highly condensed keratohyalin granules. The pathophysiologic mechanism of vitamin B12 deficiency associated with pigmentary disturbances and change of nuclear size is discussed.
Granuloma Annulare, Necrobiosis Lipoidica, and Diabetic Disease
Authors: Binazzi Maurizio , Simonetti V
Published: May 2007

ABSTRACT: One hundred sixteen patients with granuloma annulare and necrobiosis lipoidica were studied. The relationship of these two disorders with diabetes mellitus suggests that atypical granuloma annulare could be linked to necrobiosis lipoidica, toward which it progresses.
Necrotizing Fasciitis
Authors: Tharakaram S. , Keczkes K.
Published: May 2007

ABSTRACT: Five patients with necrotizing fasciitis are reported. Streptococci were isolated in all but one patient, in whom Staphylococcus albus was responsible. Other organisms were also isolated in culture. Surgical debridement and skin grafting were needed in all our patients, in addition to systemic antibiotics and topical treatment, comprising Eusol paraffin soaks. One patient developed this condition after a skin biopsy; another had chronic venous leg ulcer. There was no predisposing cause in the remaining three patients.
Transdermal Delivery of Salicylic Acid in the Treatment of Viral Papillomas
Authors: Mottaz Jess H. , Mckeever Patrick J. , Neveaux John L. , Zelickson Alvin S.
Published: May 2007

ABSTRACT: Healthy adult (New Zealand, Dutch Belt, and Wild) rabbits were infected with rabbit papilloma virus (Shope variety). The resultant papillomas were treated with salicylic acid in a new transdermal drug delivery system utilizing a karaya gum glycol matrix. Biopsy samples of treated papillomas were taken at 1, 2, and 3 weeks after initiation of treatment and examined by electron microscopy. The observed changes during the course of treatment indicated that the karaya gum glycol matrix effectively released salicylic acid into the stratum corneum. Further, the rate of delivery of salicylic acid was such that the desired keratolytic activity was achieved with minimal inflammatory response.
Metastases to the Skin
Authors: Tharakaram S.
Published: May 2007

ABSTRACT: Fifty patients (26 men and 24 women) with cutaneous metastases were studied clinically and histologically. Analysis on the basis of the site of the primary tumor showed carcinoma of the lung and esophagus to be the commonest tumors responsible in men and carcinoma of the breast and ovaries the commonest in women. Metastases occurred in all areas of the skin with the chest wall the commonest site, especially in carcinoma of the breast. Most of the cutaneous metastases occurred after the primary malignancy was manifest and well advanced; only in two cases were they the presenting signs of the malignancy.
The HLA Association of Lepromatous Leprosy and Borderline Lepromatous Leprosy in Turkey
Authors: Mat M. Cem , Yazici Hasan , ÖZbakir Fatma , Tüzün Yalçlin
Published: May 2007

ABSTRACT: Among 50 patients with lepromatous leprosy and borderline lepromatous leprosy in Turkey, the prevalence of HLA‐DR2 was 25/50 (50%). The prevalence of the same alleles among 50 healthy controls was 13/50 (26%).