bluuebunny/crossref_metadata_2025 huggingface dataset:
Downregulation of miR-125a-5p Leads to STAT3 Increased Expression in
Breast Cancer Patients
Authors: Shishavan Negar Shafagh , Sasani Soheila Talesh , Salehi Zivar , Azhang Masoumeh Rezaei
Published: September 2022

Background:

Breast cancer (BC) is one of the main causes of cancer-related death in
women worldwide. It is necessary to find methods for prognosis and early detection of BC. MicroRNAs
inhibit the expression of special target genes at the post-transcriptional stage and have a
fundamental role in various cancers. They function as oncogenes or tumor suppressors. MiR-125a-
5p acts as a tumor suppressor in some cancers through a signal transducer and activator of transcription
3 (STAT3) suppression. STAT3 is activated in response to cytokines and growth factors, affecting
the transcription of target genes.

Objective:

We examined the association between miR-125a-5p and STAT3 expression levels in
breast cancer patients for the first time through a case-control study on an Iranian population.

Methods:

Total RNAs were extracted from breast cancer and healthy tissues using TRIzol Reagent.
Complementary DNA synthesis was performed, and Real-time PCR was done using miR-125a and
STAT3-specific primers. GAPDH and U48 genes were used as internal controls. Statistical analysis
of the results was conducted by SPSS v.19.0 software.

Results:

We obtained a significant association between miR-125a-5p down-regulation and breast
cancer disease (0.4333 in patients vs. 1.656 in controls, p-value = 0.009). STAT3 expression was
significantly up-regulated in BC samples relative to healthy subjects (1.324 vs. 0.6557, respectively)
and p-value <0.0001.

Conclusion:

We investigated that decreased miR-125a-5p expression levels were significantly associated
with increased STAT3 expression in BC tissues. Therefore, the expression changes of miR-
125a-5p can be an important potential biomarker for early diagnosis of breast cancer. Also, the
miRNA molecule may have serious therapeutic potential.
New Insights into Biological and Pharmaceutical Properties of Bioactive Compounds in Various Diseases of Farm Animals
Authors: Keelka Sneha , Kaushik Pallavi , Kumar Sharma Mukesh
Published: September 2022

Farm animals have a crucial role in producing sources of protein and other
nutritive products for humans. However, these animals are confronting diverse
challenging ailments and subsequent oxidative stress, which reduces the efficiency of
production and impairs animal welfare. Bioactive compounds obtained from plants and
other natural provenances have now been accredited as the crucial steppingstone
against the numerous persistent diseases encountered by farm animals. Bioactive
compounds possess remarkable molecular diversity and modulate numerous metabolic
processes with high precedence goals, low toxicity, exhibiting high efficacy with low
cost, easy availability with less or no side effects.
In this context, the chapter addresses recently observed bioactive compounds for the
treatment of various livestock diseases. Moreover, an attempt to consolidate
information on numerous bioactive compounds has been made which brings aid in
unrelenting research into potential use
Pharmacological Properties of Bacterial Bioactive Molecules
Authors: Keelka Sneha , Kaushik Pallavi , Jain Prachi , Kumar Sharma Mukesh
Published: September 2022

The pure or standardized extracts obtained from microbes like bacteria,
fungi, actinomycetes, etc. are considered important sources of bioactive compounds.
Some of the microbes show inhibitory action against the growth of certain bacteria,
fungi, yeast, insects, etc. This provides opportunities for the development of newer
drugs and enzymes or beneficial compounds. Large number of bacteria are responsible
for producing different bioactive compounds like antibiotics, enzymes, and other
secondary metabolites. Some compounds like Gallic acid, Amicoumacin, Prodigiosin,
Nystatin, Spinosad, Milbemycin, Lipstatin, Subtilin, Albaflavenone, and Mollemycin A
have been studied for their affectivity against bacterial, fungal, insects, pests, etc. These
compounds are gaining increasing interest because of their unique composition and the
possibility of wide industrial applications.
The Politicization of Population Data Governance in the Perspective of Principal-Agent: Case Study in Indonesia
Authors: Misran Misran , Muallidin Isnaini , Nanaman Marilou Siton , Prasetyo Satria Iman
Published: September 2022

Indonesia is one of the world's developing countries. The thing that is most often found in developing countries is vast populations. As one of the countries with the highest demographic bonus, Indonesia ranks at the top of the list for the world's population density. The complexity of the problem of population data in Indonesia has become an enormous homework for the government. The issue of this occupation data has haunted the Indonesian government for a long time. This study aims to analyze the politicization of Indonesian population data governance from the principal-agent theory. This study uses a qualitative approach. Sources of data were collected from previous studies related to the research topic by analyzing the phenomena in Indonesia. The findings of this study reveal the game of politicians and bureaucracy in playing population data. The game is in the form of politicizing data based on political interests. In the principal-agent perspective, where the contract is signed under asymmetric information, one party is aware of pertinent facts that some other side is unaware of.
Analysis a number of Quantitative Traits and Genetic Variation of Different Generation of Wheat (Tritecum aestivum) by using RAPD-PCR
Authors: Salem Alsaffar Raed
Published: September 2022

RAPD-PCR genetic markers were used to assess genetic variation in wheat plants and connections among six wheat genotypes. Four random primers produced 140 DNA fragments, averaging 6.7 identifiable bands per primer. Among the six genotypes, 85 pieces (44.64 percent) were polymorphic. Several RAPD marker bands had distinct signify recurrence patterns that thing differently amongst germplasm of wheat plants groupings. Within-community genetic variation accounted for 78 to 89 percent of the overall variance. Wheat genotypes may be characterized and classified using RAPD analysis. These findings will be a benefit in wheat-producing offspring efforts in the future.

Keywords. Barley, Genetic variation, RAPD-PCR.
Molecular study of Enterobacteriaceae bacterium isolated from dishwashers
Authors: Al-Omari Aisha W. , Ramadan Matter Ikhlas , Hussein Almola Alaa
Published: September 2022

The Enterobacteriaceae family is considered one of the medically essential families in which there is a continuous change in classification, and new species are added to it. In this study, we obtained a novel strain registered in the NCBI under Enterobacteriaceae bacterium strain PRL 4-2, with the accession number MW540823, and the isolate considered unclassified Enterobacteriaceae. The isolate was obtained from dishwashers, which is a mine for many new species and strains due to the unique environmental conditions of this habitat, fluctuation in temperature, use of high temperatures, utilization of cleaning materials as well as humidity and the presence of organic materials, especially in case of neglect of cleaning. The isolate was characterized by its slow growth on culture media and its ability to form biofilms and possess some virulence factors. Its resistance to antibiotics was also studied, as it showed resistance to the antibiotics used in this study. The oddness for this strain is that it showed a different diagnosis when using VITEK (The VITEK 2 system has everything healthcare laboratories need for fast, accurate microbial identification and antibiotic susceptibility testing.) compared to diagnosis using 16S rRNA. As for the taxonomic tree, the closest species was Enterobacter sp. Strain 188. This study supplements a few other studies of this novel species, isolated from different environments. These researches can be integrated to give an itinerary for other studies on the new species and their different capabilities.

Keywords. Enterobacteriaceae bacterium, dishwasher, Enterobacteriaceae bacterium PRL-2, Enterobacter sp., biofilm.
Cognitive Behavioral Therapy Plus a Serious Game as a Complementary Tool for a Patient With Parkinson Disease and Impulse Control Disorder: Case Report
Authors: Mena-Moreno Teresa , Munguía Lucero , Granero Rosario , Lucas Ignacio , Sánchez-Gómez Almudena , Cámara Ana , Compta Yaroslau , Valldeoriola Francesc , Fernandez-Aranda Fernando , Sauvaget Anne , Menchón José M , Jiménez-Murcia Susana
Published: September 2022

Background

Impulse control disorders (ICDs) are commonly developed among patients who take dopamine agonist drugs as a treatment for Parkinson disease (PD). Gambling disorder and hypersexuality are more frequent in male patients with PD, with a prevalence over 4% in dopamine agonists users. Although impulsive-compulsive behaviors are related to antiparkinsonian medication, and even though ICD symptomatology, such as hypersexuality, often subsides when the dopaminergic dose is reduced, sometimes ICD persists in spite of drug adjustment. Consequently, a multidisciplinary approach should be considered to address these comorbidities and to explore new forms of complementary interventions, such as serious games or therapies adapted to PD.

Objective

The aim of this study is to present the case of a patient with ICD (ie, hypersexuality) triggered by dopaminergic medication for PD. A combined intervention was carried out using cognitive behavioral therapy (CBT) for ICD adapted to PD, plus an intervention using a serious game—e-Estesia—whose objective is to improve emotion regulation and impulsivity. The aim of the combination of these interventions was to reduce the harm of the disease.

Methods

After 20 CBT sessions, the patient received the e-Estesia intervention over 15 sessions. Repeated measures, before and after the combined intervention, were administered to assess emotion regulation, general psychopathology, and emotional distress and impulsivity.

Results

After the intervention with CBT techniques and e-Estesia, the patient presented fewer difficulties to regulate emotion, less emotional distress, and lower levels of impulsivity in comparison to before the treatment. Moreover, the frequency and severity of the relapses also decreased.

Conclusions

The combined intervention—CBT and a serious game—showed positive results in terms of treatment outcomes.
A Conceptual Model of Experiences With Digital Technologies in Aging in Place: Qualitative Systematic Review and Meta-synthesis
Authors: Hechinger Mareike , Hentschel Diana , Aumer Christine , Rester Christian
Published: September 2022

Background

Older adults with chronic illnesses or dependency on care who strive to age in place need support and care depending on their illness. Digital technology has enabled the possibility of supporting older adults in their wishes to age in place. However, current studies have mainly focused on the solitary evaluation of individual technologies or on evaluating technologies for specific illnesses.

Objective

This study aimed to synthesize research on the experiences of older people from the Western culture with chronic illnesses or care needs and their families with digital technology for aging in place. From the meta-synthesis, a model was derived that can be useful for the development of assistive devices in old age and that can support health care providers and professionals in their work with affected individuals.

Methods

A systematic review and qualitative meta-synthesis was performed using an inductive approach, as proposed by Sandelowski and Barroso. We performed a systematic literature search in 6 databases from 2000 to 2019, with an update in 2021 and, in addition, conducted a hand search in 2 databases, relevant journals, and reference lists. The results of each study were analyzed using initial and axial coding, followed by theoretical coding. A conceptual model was derived.

Results

A total of 7776 articles were identified. Articles were screened independently by 2 authors based on the eligibility criteria. Finally, of the 7776 studies, 18 (0.23%) were included in the meta-synthesis. The derived conceptual model describes older adults with chronic illnesses or dependency on care and their family members in an individual process of reflection and decision-making, starting with the use of a digital device. Older adults live in times of change. They experience stable and unstable times of illness as they are part of a changing digital world. Hence, older adults and their families consider digital technology a solution to their current situation. As they become familiar with a specific digital technology, they refine their needs and demands, gain confidence in its use, and note its advantages and disadvantages. They weigh hopes, needs, demands, and experiences in a process of reflection to decide on convenience and inconvenience. Independent of their decision, they achieve peace of mind either with or without digital technology. This process can restart repeatedly during the illness trajectory of older adults.

Conclusions

This study promotes a differentiated understanding of older adults’ experiences with digital technology. The conceptual model can be useful for the development of assistive technology in old age. Moreover, it can guide health care professionals in their work with older adults and their families to provide individual counseling to find the appropriate digital technology for their respective situations.
Assessing the Acceptability of Home Blood Monitoring for Patients With Cancer Who Are Receiving Systemic Anticancer Therapy From a Patient, Caregiver, and Clinician Perspective: Focus Group and Interview Study
Authors: Vercell Amy , Taylor Sally , Yorke Janelle , Dowding Dawn
Published: September 2022

Background

Regular blood testing is an integral part of systemic anticancer therapy delivery. Blood tests are required before every administration of treatment to ensure that a patient is sufficiently well to receive it. Blood testing is burdensome for patients as they require either an extra visit within 48 hours of planned administration of treatment or a significantly long visit if performed on the day of treatment. The additional time for appointments can have a significant impact on the quality of life of someone who is living with cancer. In the United Kingdom, the COVID-19 pandemic created unprecedented disruption to the delivery of cancer care. Face-to-face hospital visits were reduced, resulting in the need to develop more innovative ways of working to minimize treatment interruptions. This led to significant uptake of digital technologies, with new models of care rapidly deployed across the UK health service to meet these challenges.

Objective

This study aimed to explore the acceptability of a point-of-care home blood monitoring device for people with cancer who are receiving systemic anticancer therapy, which is being developed in response to the increased need for remote care for patients with cancer.

Methods

Qualitative focus groups and semistructured interviews were conducted with patients (23/47, 49%), caregivers (6/47, 13%), and health care professionals (18/47, 38%) over a 19-month time frame from May 2019 to December 2020. Data were analyzed using framework analysis guided by the Unified Theory of Acceptance and Use of Technology model.

Results

Analysis identified 4 overarching themes: performance expectancy, effort expectancy, social influence, and facilitating conditions.

Conclusions

This study found that patients with cancer, their caregivers, and health care professionals had positive perceptions about home blood monitoring. Although they are often considered synonymously, self-testing and self-management are not mutually exclusive, and this study illustrated some disparity in opinions regarding patient self-management. Home blood monitoring has the potential to provide patients with cancer with a convenient option for blood monitoring. It would minimize hospital attendances, decrease late treatment deferrals, and provide prompt recognition of cancer treatment toxicities, thus enhancing the existing nurse-led protocols and clinical pathways. Home blood monitoring would create a long-term sustainable transformation for the delivery of cancer care, using digital health to act as a facilitator to address a pertinent issue regarding improving the efficiency of hospital resources and increasing the delivery of personalized patient care. Further studies are needed to determine how and where home blood monitoring would fit within clinical pathways, in a way that is robust and equitable.
Group Antenatal Care in Ghana: Protocol for a Cluster Randomized Controlled Trial
Authors: Lori Jody R , Williams John E O , Kukula Vida A , Apetorgbor Veronica E A , Awini Elizabeth A , Amankwah Georgina , Zielinski Ruth , Lockhart Nancy , James Katherine H , Moyer Cheryl A
Published: September 2022

Background

While group antenatal care (ANC) has been delivered and studied in high-income countries for over a decade, it has only recently been introduced as an alternative to individual care in sub-Saharan Africa. Although the experimental design of the studies from high-resource countries have been scientifically rigorous, findings cannot be generalized to low-resource countries with low literacy rates and high rates of maternal and newborn morbidity and mortality. The Group Antenatal Care Delivery Project (GRAND) is a collaboration between the University of Michigan in the United States and the Dodowa Health Research Centre in Ghana. GRAND is a 5-year, cluster randomized controlled trial (RCT). Our intervention—group ANC—consists of grouping women by similar gestational ages of pregnancy into small groups at the first ANC visit. They then meet with the same group and the same midwife at the recommended intervals for care.

Objective

This study aims to improve health literacy, increase birth preparedness and complication readiness, and optimize maternal and newborn outcomes among women attending ANC at seven rural health facilities in the Eastern Region of Ghana.

Methods

Quantitative data will be collected at four time points using a secure web application for data collection and a database management tool. Data will be analyzed on an intention-to-treat basis to test the differences between the two arms: women randomized to group-based ANC and women randomized to routine individual ANC. We will conduct a process evaluation concurrently to identify and document patient, provider, and system barriers and facilitators to program implementation.

Results

The study was funded in September 2018. Recruitment and enrollment of participants and data collection started in July 2019. In November 2021, we completed participant enrollment in the study (n=1761), and we completed data collection at the third trimester in May 2022 (n=1284). Data collection at the additional three time points is ongoing: 6 weeks postpartum, 6 months postpartum, and 1 year postpartum.

Conclusions

This study is significant and timely because it is among the first RCTs to be conducted to examine the effects of group ANC among low-literacy and nonliterate participants. Our findings have the potential to impact how clinical care is delivered to low-literacy populations, both globally and domestically, to improve maternal and newborn outcomes.

Trial Registration

ClinicalTrials.gov NCT04033003; https://clinicaltrials.gov/ct2/show/NCT04033003

International Registered Report Identifier (IRRID)

DERR1-10.2196/40828
Factors impacting mobile health for depression adoption by adolescent mothers in Nigeria (Preprint)
Authors: Kola Lola , Fatodu Tobi , Kumar Manasi , Kola Manasseh , Olayemi Bisola A , Adefolarin Adeyinka , Dania Simpa , Ben-Zeev Dror
Published: September 2022

BACKGROUND

Mobile Health (mHealth), the use of mobile technology in health care, is increasingly being used for mental health service delivery even in Low-Middle-Income countries (LMICs) to scale-up treatment, and a variety of evidence supports their potentials in different populations

OBJECTIVE

In this study, we utilise a theoretical lens to explain the personal, behavioural and social/environmental factors impacting the adoption of a mobile health application for depression care among perinatal adolescents in Nigeria.

METHODS

At the preliminary stage of a User-Centered design (UCD), 4 Focus Group Discussions were conducted among 38 participants:19 perinatal adolescents with a history of depression and 20 primary care providers. We documented information on participants' knowledge of mobile health use for health purposes (mHealth), advantages and challenges to the adoption of a mHealth application (app) by young mothers, and approaches to mitigate challenges. Data collection and analysis was an iterative process until saturation of all topic areas was reached.

RESULTS

The mean age for young mothers was 17.3+0.9 years and (48+5.8) for care providers. Mistrust from relatives on mobile phone use for therapeutic purposes, avoidance of clinic appointments, and sharing of app contents with friends were some challenges to adoption identified in the study population. Supportive personal factors and expressions of self-efficacy on mobile app users were found to be insufficient for adoption, given the social complications of getting pregnant at a young age. Adequate engagement of parents/guardians/partners on mHealth solutions by care providers was identified as necessary to uptake of digital tools for mental health care in this population.

CONCLUSIONS

Communications between care providers and patients' relatives on the therapeutic use of mobile health are vital stakeholders to the success of a mHealth mental health management plan for depression in young mothers in Nigeria.
Prevalence of Apparent Treatment-Resistant Hypertension in Chronic Kidney Disease in Two Large US Health Care Systems
Authors: An Jaejin , Kurella Tamura Manjula , Odden Michelle C. , Ni Liang , Thomas I-Chun , Montez-Rath Maria E. , Sim John J.
Published: September 2022

Background and objectives

More intensive BP goals have been recommended for patients with CKD. We estimated the prevalence of apparent treatment-resistant hypertension among patients with CKD according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA; BP goal <130/80 mm Hg) and 2021 Kidney Disease Improving Global Outcomes (KDIGO; systolic BP <120 mm Hg) guidelines in two US health care systems.

Design, setting, participants, & measurements

We included adults with CKD (an eGFR <60 ml/min per 1.73 m2) and treated hypertension from Kaiser Permanente Southern California and the Veterans Health Administration. Using electronic health records, we identified apparent treatment-resistant hypertension on the basis of (1) BP above the goal while prescribed three or more classes of antihypertensive medications or (2) prescribed four or more classes of antihypertensive medications regardless of BP. In a sensitivity analysis, we required diuretic use to be classified as apparent treatment-resistant hypertension. We estimated the prevalence of apparent treatment-resistant hypertension per clinical guideline and by CKD stage.

Results

Among 44,543 Kaiser Permanente Southern California and 241,465 Veterans Health Administration patients with CKD and treated hypertension, the prevalence rates of apparent treatment-resistant hypertension were 39% (Kaiser Permanente Southern California) and 35% (Veterans Health Administration) per the 2017 ACC/AHA guideline and 48% (Kaiser Permanente Southern California) and 55% (Veterans Health Administration) per the 2021 KDIGO guideline. By requiring a diuretic as a criterion for apparent treatment-resistant hypertension, the prevalence rates of apparent treatment-resistant hypertension were lowered to 31% (Kaiser Permanente Southern California) and 23% (Veterans Health Administration) per the 2017 ACC/AHA guideline. The prevalence rates of apparent treatment-resistant hypertension were progressively higher at more advanced stages of CKD (34%/33%, 42%/36%, 52%/41%, and 60%/37% for Kaiser Permanente Southern California/Veterans Health Administration eGFR 45–59, 30–44, 15–29, and <15 ml/min per 1.73 m2, respectively) per the 2017 ACC/AHA guideline.

Conclusions

Depending on the CKD stage, up to a half of patients with CKD met apparent treatment-resistant hypertension criteria.
Entre la extinción y la reconversión: ¿por qué la radio se escucha cada vez menos?
Authors: Trejo Delarbre Raúl
Published: September 2022

Hoy en día solamente 3.5 de cada 10 mexicanos escuchan radio. En 2005 casi 90 % de los hogares en México tenía, por lo menos, un aparato radiorreceptor; quince años después, solamente lo tenían en 51 % de las residencias.  Esa caída de audiencias, principalmente, es resultado de la expansión de plataformas digitales y no está directamente vinculada con la situación socioeconómica de los radioescuchas. En este artículo se documenta esta drástica disminución de audiencias y, a partir de información de instituciones como el inegi, se muestra el interés por consumir este medio en cada estado del país. Se perfilan algunas explicaciones para comprender dicho cambio en la recepción de la radio. Como conclusión, planteamos que las opciones para el consumo de contenidos audiovisuales se han multiplicado, las nuevas audiencias buscan formatos másflexibles y muchas personas diseñan su menú de consumo mediático, entre otras circunstancias. Finalmente, en México, su excesiva comercialización ha limitado la diversidad y calidad de sus contenidos.
Sucesión ecológica en un matorral xerófilo: una hipótesis explicativa
Authors: Flores-Estrada Yolanda Maribel , Monroy-Ata Arcadio
Published: September 2022

La sucesión ecológica es un proceso de sustitución de una comunidad biótica por otra con una mayor estructuración y funcionalidad, durante la maduración de un ecosistema. También, es un proceso de autoorganización de las comunidades bióticas, en el que los organismos se relacionan o asocian para regular y controlar el flujo de la energía y los ciclos de la materia orgánica, lo cual normalmente se orienta a conformar sistemas ecológicos cada vez más resilientes. En este trabajo se presenta un análisis de los datos reportados sobre la sucesión vegetal en un matorral xerófilo del Valle del Mezquital, Hidalgo en México. Los resultados muestran que hay una secuencia gradual hacia una mayor estructuración y funcionalidad del ecosistema, durante la maduración del matorral xerófilo, que sustenta un creciente aprovechamiento de los recursos hídricos locales. Finalmente, se concluye que la tendencia sucesional no es hacia el incremento de la complejidad ecosistémica, sino hacia el aumento de la estructuración de la comunidad biótica, con organización cooperativa y mutualismos como interacciones dominantes, de tal forma que el ecosistema puede incrementar su funcionalidad.
Study of Radial Part of Pseudo wave Function using Pseudo-spherical Methodology in Condenser Matter
Authors: Kolhe K. G.
Published: September 2022

Abstract: The radial part of Fl(r) of the pseudo Schrödinger equation has been developed in pseudo potential approach. Also the pseudo spherical function Fl(r), the radial part of pseudo wave function k(r, , ) is expressed in terms of ion-core electron density, Pl(r) of Hartree or Hartree-Fock one electron wave function k(r, , ) To develop the present equation, a new pseudo spherical function Yl(r) has been investigated which is helpful in determining many types of electron densities.
Study of Temperature Sensor (TMP139) based on I3C Interface
Authors: Kulkarni Manjiri , Meharunnisa Dr S P
Published: September 2022

Abstract: In the current digital world with all smart and compact devices, the monitoring and controlling aspects of device parameters is a crucial role. One such crucial parameter for a digital device is the heating of the device and its maintenance. Temperature sensors come into the picture for such controlling and monitoring applications, for example, in devices like laptops, handheld phones, SSD, and many other industrial devices. A temperature sensor with a high accuracy rate is introduced by Texas Instruments called TMP139, which uses the latest I3C protocol for its function. This paper relates to a study of this sensor that is compatible with the I3C protocol
A Comparable genetic diversity between chicken ecotypes of different zones using DNA barcoding
Authors: Sabry Ayman , Ahmed  Mohamed Alaa , Hassan Mohamed , E. M. Abo-Aba Salah
Published: September 2022

Objectives: The purpose of the current study was to verify the reliability of COI bar- codes in the assessment of genetic diversity of two ecotypes from different ecozones.

Methods: The DNA sequences of cytochrome oxidase I (COI) barcodes of 50 hens belonging to two ecotypes of Ismalia Egypt (ISM) and Taif Saudi Arabia (TA) were isolated and analyzed.

Results: This study results showed that no noticeable great differences among all barcode’s sequences of both ecotypes. The aver- age length of both ecotypes was 589 bp. ISM ecotypes have a relatively wider length range. The overall mean of GC% content was 48±0.01. Both ecotypes have the same number of sites 548 bp. ISM ecotype has 523 monomorphic sites whereas TA ecotype has slightly fewer monomorphic sites 517. The ISM ecotype has 7 singleton sites and 18 Parsimony informative sites. TA ecotype has little more polymorphic, that is 12 singleton sites and 19 Par- simony informative sites. The number of mutations (η) was larger in ISM (46) compared to 38 mutations for TA ecotype. Both ecotypes had the same number of Haplotypes (25), and haplotypes diversity (1) as well as the variance of haplotype diversity.

Conclusion: These results indicated a comparable level of genetic diversity of both ecotypes, which in turn may refer to a similarity of evolutionary forces that affect both ecotypes. Based on the present results, COI gene can be used in barcoding. The COI provides an objective the foundation for identification of ecotypes and therefore could be used for a rapid establishment of a variety of identifications.
Efecto del peso y la puntuación de la condición corporal de vacas gestantes en las características de la canal de su progenie: Meta análisis
Authors: Adams Sander Martinho , Klein John Lenon , Machado Diego Soares , Alves Filho Dari Celestino , Brondani Ivan Luiz , Pizzuti Luiz Angelo Damian
Published: September 2022

The objective of the meta-analysis was to evaluate the effects of beef cows weight variation during the 2nd and / or 3rd trimester pregnancy on some parameters of the progeny carcass. The cow weight gain during this gestational period was calculated to standardize the treatments: moderate loss (ML= cows that lost 0 to 5 % of weight) and moderate gain (MG= cows that gained 0 to 5 % of weight). The effect size for all parameters was calculated as medium difference (MD) with a 95% confidence interval and heterogeneity determined using the Q test and the I2 statistic. A random effects meta-analysis was performed for each indicator separately as the medium control and experimental groups. The cow’s weight variation during the studied time variation did not influence the progeny carcass characteristics (P>0.05). Although, a trend towards greater hot carcass weight (P=0.15) and thickness of subcutaneous fat (P=0.10) was observed in calves from MG cows in relation to calves from ML cows. However, the meta-analysis demonstrated that small variations in cow weight during the final half of pregnancy do not affect progeny carcass characteristics.
Liderazgo y grupos generacionales: Caso de estudio en una entidad financiera
Authors: Andrade Lilian , Fernanda-Bolaños María , López Héctor
Published: September 2022

El propósito de esta investigación fue conocer si el estilo de liderazgo tiene relación con cada generación y si las diferencias generacionales influyen en la preferencia o percepción sobre sus líderes; tomando como caso de estudio una institución financiera ubicada en la provincia de Imbabura en Ecuador, empleando como instrumento el Cuestionario de Liderazgo Multifactorial MLQ, que fue aplicado a 61 empleados. Los resultados mostraron que el liderazgo predominante es transformacional, la generación que prevalece es la Millennial; el tipo de liderazgo y las generaciones no están relacionados porque la preferencia se concentró en el liderazgo transformacional independientemente de la generación a la que pertenecía el personal, por último, el tipo de liderazgo predominante consigue en las personas resultados basados en efectividad, satisfacción y esfuerzo extra, sin relacionar la generación a la que pertenecen; es decir, los comportamientos del líder, obtienen respuesta de las dos generaciones presentes en las agencias.
JEL Classification: J24, M12, M54
Re-operative aortic valve replacement via upper partial re-sternotomy in a patient with patent internal thoracic artery after coronary artery bypass grafting: A case report
Authors: Kitashima Fumihiro , Shirouzu Miyo , Tanaka Masashi
Published: September 2022

A 71-year-old man who had undergone coronary artery bypass grafting with
left internal thoracic artery (LITA) and saphenous vein graft (SVG) 7
years previously was referred to our hospital for dyspnea on exertion.
Transthoracic echocardiography (TTE) showed severe aortic stenosis and
regurgitation. Contrast-enhanced computed tomography revealed patent
LITA anastomosed to the left anterior descending (LAD) coronary artery
and SVG to the left circumflex artery near the ascending aorta.
Re-operative aortic valve replacement (AVR) was performed via upper
partial re-sternotomy through an inverted T-shaped incision. The patent
LITA was dissected and clamped successfully with minimal adhesion
detachment. Postoperative TTE revealed a patent LITA anastomosed to LAD.
No complications occurred, and the patient was discharged on
postoperative day 17.
Bilateral anterior ischemic optic neuropathy and secondary angle-closure glaucoma in a patient with COVID-19 infection
Authors: Shahri Seyed Hossein Ghavami , Abrishami Mojtaba , Shayanfar Helia , khazaei sahel
Published: September 2022

A 57-year-old male known case of diabetes mellitus presented with
gradually bilateral decreased vision accompanied by ocular pain two
weeks after SARS-CoV-2 infection. Ophthalmic examination and imaging
were indicative of bilateral anterior ischemic optic neuropathy and
secondary angle-closure glaucoma associated with increased choroidal
thickness and hypercoagulable state following COVID-19 infection.
Successful treatment of a patient with subungual warts using paiteling：A Case Report
Authors: Qi Xinyu , Yao Wang
Published: September 2022

Background：There are many methods to treat subungual wart, but the
treatment results are not satisfactory. Case presentation：A patient
with a 10-year history of subungual warts was cured after using
paiteling, and no warts recurred after six months of follow-up.
Conclusion：Paiteling is effective and safe to treat subungual warts.
Supporting Information for "Ingestible Functional Magnetic Robot with Localized Flexibility (MR-LF)"
Authors: Greenwood Taylor E. , Cagle Henry , Pulver Benson , Pak On Shun , Kong Yong Lin
Published: September 2022

This Supporting Information includes information regarding the magnetic
field of the actuator magnet, MR-LF-S (which has the same geometry as
MR-LF and a soft compartment), and a table comparing MR-LF to other
small-scale, flexible magnetic crawler robots.

 Corresponding author email:   yong.kong@utah.edu
Ca2+ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes
Authors: Gosak Marko , Yan-Do Richard , Lin Haopeng , MacDonald Patrick E. , Stožer Andraž
Published: September 2022

Pancreatic islets are highly interconnected structures that produce pulses of insulin and other hormones, maintaining normal homeostasis of glucose and other nutrients. Normal stimulus-secretion and intercellular coupling are essential to regulated secretory responses, and these hallmarks are known to be altered in diabetes. In the current study, we used calcium imaging of isolated human islets to assess their collective behavior. The activity occurred in the form of calcium oscillations, was synchronized across different regions of islets through calcium waves, and was glucose dependent: higher glucose enhanced the activity, elicited a greater proportion of global calcium waves, and led to denser and less fragmented functional networks. Hub regions were identified in stimulatory conditions, and they were characterized by long active times. Moreover, calcium waves were found to be initiated in different subregions and the roles of initiators and hubs did not overlap. In type 2 diabetes, glucose dependence was retained, but reduced activity, locally restricted waves, and more segregated networks were detected compared with control islets. Interestingly, hub regions seemed to suffer the most by losing a disproportionately large fraction of connections. These changes affected islets from donors with diabetes in a heterogeneous manner.
Haptoglobin Genotype Does Not Confer a Risk of Stroke in Type 1 Diabetes
Authors: Syreeni Anna , Dahlström Emma H. , Hägg-Holmberg Stefanie , Forsblom Carol , Eriksson Marika I. , Harjutsalo Valma , Putaala Jukka , Groop Per-Henrik , Sandholm Niina , Thorn Lena M.
Published: September 2022

The exon copy number variant in the haptoglobin gene is associated with cardiovascular and kidney disease. For stroke, previous research is inconclusive. We aimed to study the relationship between the haptoglobin Hp1/2 genotype and stroke in individuals with type 1 diabetes from the Finnish Diabetic Nephropathy Study. We included two partially overlapping cohorts: one with haptoglobin genotypes determined using genotyping for 179 individuals with stroke and 517 matched control subjects, and the other using haptoglobin genotype imputation for a larger cohort of 500 individuals with stroke and 3,806 individuals without stroke. We observed no difference in the Hp1-1, Hp2-1, and Hp2-2 genotype frequencies between individuals with or without stroke, neither in the genotyping nor the imputation cohorts. Haptoglobin genotypes were also not associated with the ischemic or hemorrhagic stroke subtypes. In our imputed haptoglobin cohort, 61% of individuals with stroke died during follow-up. However, the risk of death was not related to the haptoglobin genotype. Diabetic kidney disease and cardiovascular events were common in the cohort, but the haptoglobin genotypes were not associated with stroke when stratified by these complications. To conclude, the Hp1/2 genotypes did not affect the risk of stroke or survival after stroke in our cohort with type 1 diabetes.
Haptoglobin Genotype Does Not Confer a Risk of Stroke in Type 1 Diabetes
Authors: Syreeni Anna , Dahlström Emma H. , Hägg-Holmberg Stefanie , Forsblom Carol , Eriksson Marika I. , Harjutsalo Valma , Putaala Jukka , Groop Per-Henrik , Sandholm Niina , Thorn Lena M. , Group on behalf of the FinnDiane Study
Published: September 2022

The exon copy number variant in the haptoglobin gene is associated with cardiovascular and kidney disease. For stroke, previous research is inconclusive. We aimed to study the relationship between haptoglobin Hp1/2 genotype and stroke in individuals with type 1 diabetes from the Finnish Diabetic Nephropathy Study. We included two partially overlapping cohorts: one with haptoglobin genotypes determined using genotyping for 179 stroke cases and 517 matched controls, and the other using haptoglobin genotype imputation for a larger cohort of 500 stroke cases and 3,806 controls. We observed no difference in the Hp1-1, Hp2-1, and Hp2-2 genotype frequencies between the stroke cases and controls, neither in the genotyping nor the imputation cohorts. Haptoglobin genotypes were also not associated with the ischemic or hemorrhagic stroke subtypes. In our imputed haptoglobin cohort, 61% of individuals with stroke died during follow-up. However, the risk of death was not related to the haptoglobin genotype. Diabetic kidney disease and cardiovascular events were common in the cohort, but the haptoglobin genotypes were not associated with stroke when stratified by these complications. To conclude, the Hp1/2 genotypes did not affect the risk of stroke or survival after stroke in our type 1 diabetes cohort.

 
Morphophonological Features of Lɛtɛ Loanwords from English
Authors: Obiri Yeboah Mornica Apenteng , Akrofi Ansah Mercy
Published: September 2022

The aim of this paper is two-fold: to describe the phonological and morphological features of English loanwords (nouns and verbs) which appear in Lɛtɛ lexicon and to identify and account for the largest semantic class of English loanwords. Lɛtɛ (Kwa: Guan) is spoken in Larteh, a town in southeast Ghana. The language has not received much attention, and as such, there has been no study to investigate the phenomenon of lexical borrowing in the language. The linguistic situation in Larteh is characterized by trigglosia, a situation where three languages with distinct communicative functions are in use. Akuapem Twi is the second language of most Lɛtɛ speakers. The paper distinguishes between codeswitching from borrowing to initiate the discussion from the right perspective. Motivation for borrowing from English primarily stems from the need to fill lexical gaps in Lɛtɛ. Consequently, data for the study suggest that the semantic class of science and technology is the largest of all the semantic domains of English loanwords. Data sources include bilingual wordlists of English and Lɛtɛ; focus group discussions and Lɛtɛ folktales. Upon analyzing the data, we observed that English loanwords undergo morphological and phonological alterations such as epenthesis and vowel harmonization to become nativized. The study is underpinned by the Matrix Language Frame Model (MLFM) (Myers-Scotton, 1997; Myers-Scotton et al., 2002), a model which is designed to account for bilingual speech. Following the MLFM, lexical items which enter Lɛtɛ lexicon are expected to take up morphological and phonological features of the language. Our study however found out that not all loanwords exhibit morphophonological features of Lɛtɛ; in the case of loan nouns, the Akuapem Twi number markers are rather employed. The paper adds to existing literature on borrowing and points out that a matrix language does not always dictate new linguistics features that are borne by the loanwords, but the linguistic situation of the recipient language community, coupled with the language repertoire of speakers play a roleю
Monitoring the work of the test laboratory by participating in the proficiency testing program in the field of the laser performance measurements
Authors: Kolobrodov Valentin , Sokol Viktoriia , Polikarpov Oleksii , Sokol Bohdan
Published: September 2022

Monitoring the validity result is the critical requirement of the international standard ISO/IEC 17025:2017 for test and calibration laboratories to provide objective evidence of their technical competence. Applying the interlaboratory comparison, using alternative instrumentation that has been calibrated, functional checks of measuring and testing equipment, and other methods for monitoring the validity of results is not enough to have confidence in the quality of test results. Modern standards in the field of quality for test and calibration laboratories require applying other forms for assessing the characteristics of the used test method. Particularly, it concerns the participation in interlaboratory comparisons.

One of the tools that could be used for monitoring the validity result is comparing laboratory test results with the results that are obtained by other laboratories, e.g. proficiency testing. This paper presents the result of a proficiency testing program for laser performance measurements that was organized by the International provider IFM Quality Services PTY Ltd. in 2021. The purpose of the paper is to demonstrate the results of the participation of the SE “Ukrmetrteststandard” in proficiency testing of measuring laser performance, to reveal the correlation of the results comparing with the previous years and different tasks and to assess the possible causes of outliers. Twenty-two laboratories that had been accredited by the ISO/IEC 17025 standard participated in the proficiency testing. The results were evaluated using the Z-score as the performance criterion.

Potential risks of proficiency testing with a small number of participants and possible causes of results outliers were assessed.
Metrological research of a reference installation based on a high-pressure vessel
Authors: Serediuk Orest , Serediuk Denis , Vynnychuk Anna
Published: September 2022

The urgency of development and metrological research of reference installations based on high-pressure vessels, which meet the requirements of the implementation of traceability of instruments for measuring gas volume and gas volume flow rate, is considered. The operation algorithm of the specified reference installations when transferring the unit of gas volume to the gas meters under consideration is studied. Based on the algorithm and features of the operation of PVTt-type standards, a list of the analysed uncertainties of type A is formulated when estimating the volume of the calibrated high-pressure vessel; when measuring the absolute pressure and absolute temperature of gas due to the influence of instability of pressure and temperature on the gas meter under consideration due to the presence of a temperature gradient in the vessel. Uncertainties of type B, which are determined by metrological characteristics of measuring instruments, as well as the uncertainty of parameters evaluated by means of calculation, in particular the compressibility factor of the working environment, the influence of water vapour on the working environment and the influence of the discreteness of the device for collecting information about measurements from the gas meter are considered.

Formulas to quantify the combined uncertainty of measuring the volume of the calibrated vessel, the absolute pressure and absolute temperature as well as to calculate the air compressibility factor for the operating conditions of the installation are given. These parameters are the absolute pressure and absolute temperature of the gas and the compressibility factor of the working environment in the vessel at the beginning and at the end of the reproduction of the reference volume as well at the inlet of the gas meter. The expressions for calculating the combined and expanded uncertainties of PVTt-type standards are given.
Ganar la calle para ganar rendimiento: inteligencia artificial y big data en la publicidad exterior digital contemporánea
Authors: Rolandi Facundo
Published: September 2022

El presente artículo intenta analizar y problematizar, desde un punto de vista comunicacional y político, el fenómeno de la publicidad exterior digital presente en casi todas las principales ciudades del mundo contemporáneo a partir de la indagación en torno a ciertas causas y consecuencias, para luego plantear algunos desafíos y oportunidades sobre esta industria mediática en crecimiento.