bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and characterisation of carboxymethyl cellulose/carrageenan/jackfruit seed starch blend film for packaging applications
Authors:   Anna University, College of Engineering, Department of Printing and Packaging Technology, Guindy, Chennai 600025, India, Jaya Prakash Nirmala , Ramakrishnan Rejish ,   Anna University, College of Engineering, Department of Printing and Packaging Technology, Guindy, Chennai 600025, India, Vadivu Kulandhaivelu Senthil ,   Anna University, College of Engineering, Department of Printing and Packaging Technology, Guindy, Chennai 600025, India, Janani Vellaisamy Singaram Anantha ,   Anna University, Centre for Food Technology, Department of Biotechnology, Chennai, India
Published: November 2022

In this study, carboxymethyl cellulose, carrageenan-based films and a blend film with 1:1 concentration were prepared using the solvent casting method and the influence of various concentrations of jackfruit seed starch (0, 0.5, 1.0, 1.5, and 2 g) on its functional properties were investigated. The effect of jackfruit seed starch on strength properties such as tensile strength and elongation, as well as waterrelated characteristics such as water contact angle, water vapour permeability, and moisture content, were evaluated and compared with the results of the control blend films. FT-IR, TGA, SEM, XRD were performed to identify the functional group and its potential interactions, thermal stability, surface morphology and crystallinity of prepared films. The results suggests that addition of jackfruit seed starch from 0 to 1.5 g enhanced the tensile strength from 26.62 MPa to 33.26 MPa, but thereafter the tensile strength drops to 32.58 MPa and the elongation decreases. When compared to the carboxymethyl cellulose carrageenan control film, some physical parameters of the film, such as water vapour permeability and moisture content, decreased while thickness and contact angle increased significantly. The results of scanning electron microscopy exhibited rough and heterogeneous morphology for films with more starch content, while the control films exhibited smooth and homogenous structure. The presence of starch increased the crystallinity of all films, which attributed to improved thermal and mechanical stability of the prepared films.
Production and printing of solvent-based fluorescent ink for using in anti-counterfeiting documents
Authors:   Marmara University, Faculty of Applied Sciences, Printing Technologies, Istanbul, Turkey, Arman Kandirmaz Emine , Ozcan Arif ,   Marmara University, Faculty of Applied Sciences, Printing Technologies, Istanbul, Turkey
Published: November 2022

Security inks are used in areas such as money, expensive products, identity cards, passports. Generally, they are more expensive than conventional inks. A good security ink is expected to be fairly inexpensive and non-replicable. Pigments used in security ink are usually produced from rare earth elements. It is very difficult to produce ink from rare earth elements and high performance ink carrier systems are needed. There is no need for special carrier systems to produce ink from organic fluorescent pigments, and they allow cheaper ink production while reducing reproducibility. In this study, it is aimed to produce ink using organic-based fluorescent pigment. For this purpose, solvent-based ink formulations containing commercial solvent based organic fluorescent blue pigment in different ratios were prepared with polyurethane resin. The prepared inks were printed on the paper surface with the inkjet printing system. The colour properties of the prints obtained were determined under daylight and UV light. In addition, the gloss, adhesion, abrasion resistance, light fastness and drying times of the prints were determined. As a result, it has been determined that the ink produced is transparent in daylight, has a blue glow in UV light and can be used as a security ink in valuable documents.
Dynamics of thermochromic color change of pressure sensitive labels facestock made from environmentally friendly materials
Authors:   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Kulčar Rahela , Maretić Dorotea ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Vukoje Marina ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Malenica Ivan ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia
Published: November 2022

To maintain a circular economy and better sustainability, it is important to minimize the use of synthetic polymers. Nowadays, agricultural and industrial wastes or by-products are increasingly being used as raw materials in industrial processes. It has been determined that agro-industrial wastes have a high potential of cellulose fibers, which makes them an excellent resource for paper production. Recently, potential resources from non-wood raw materials for paper production, as well as cheap raw materials, have become the interest of various researchers. Since our main focus is on the study of thermochromic inks (TC) and the influence of substrate characteristics on their dynamic color change, this paper will examine the possibilities of a commercially available offset TC ink printed on several environmental friendly pressure sensitive labels (PSL) facestock compared to commonly use in PSL production. For the purpose of this study, a commercially available TC ink with an activation temperature (TA) of 29°C was used. The effect of color change, from blue to colorless, was measured through one heating and cooling cycle at several selected temperatures at six different PSL materials. Three fiber-based facestock of PSL used in this research are produced with 15% agroindustrial byproducts, 40% post-consumer recycled paper and 45% virgin wood pulp to form a high-quality natural paper. In addition, one material made from biogenic polymers facestock and two materials commonly used in labels production were used as well. The results of this research show that TC ink printed on alternative materials has a similar trend of color change and may be a good choice. Also, the influence of the color of fiber-based paper substrates on the change of TC color was noticed, which indicates the importance of colorimetric analysis of paper and TC ink before their printing.
Fluorescence spectroscopic analysis of biodegraded pressure-sensitive labels made from agro-industrial and post-consumer waste
Authors:   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Marošević Dolovski Ana , Itrić Ivanda Katarina ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Kulčar Rahela ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Pasanec Preprotić Suzana ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia
Published: November 2022

Today, more than ever, sustainability is at its highest peak of daily interest for all business sectors, especially involving label and packaging industries. Usage of paper products made from alternative fiber sources is a very important topic that directly supports circular economy in everyday life. Although paper products should be recycled or re-used as secondary source of raw - material, a vast volume of products end their life at landfill, especially still in our region, causing excessive accumulation in the environment. For the purpose of this research, fluorescence intensity was measured on three different biodegraded pressure sensitive label material samples (PSL), made from agro-industrial and postconsumer waste. PSL materials utilized in this research are widely used for labelling various products, for example, wine, luxury products, food etc. and are compiled of 3 parts: facestock, adhesive and liner. PSL materials are enriched with optical brighteners to give the final product the desired optical properties. Fluorescence spectroscopy is a direct measure of optical brightener concentration within the substrate. Biodegradation was performed by usage of soil burial test under aerobic conditions. Laboratory soil burial experiments were conducted at room temperature (25±2°C) by placing the unprinted label paper substrates; facestock and adhesive (delaminated from the liner) horizontally in field soils in 2L laboratory glass containers, orientated adhesive down. The water content of the soil was adjusted to 40 % of its maximum water retention capacity. Substrates were buried for a period of 2, 4, 7, 10 and 13 days. Sample’s fluorescence intensity was measured before and after incubation in the soil containers. The samples were dug out after designated time, rinsed with distilled water to remove soil particles from the surface, air dried and measured. Fluorescence intensity was measured by using Ocean Optics USB2000+ spectrometer using a 30 mm wide integrating sphere under (8:di) measuring geometry with the addition of LSM Series LED light source at 365 nm. LED light source is operated via a smart controller during the measurement. A constant current of 0.140 A was kept stable in order to maintain a constant excitation light source with the aim to excite fluorescence whitening agents within the samples. As previously research shows the presence of optical brighteners in composition of fibre based PSL, fluorescence spectroscopy of biodegraded samples indicates decomposition of optical brighteners.
Physico-chemical evaluation and kinetic study of coloured printing wastewater prior and post-fenton treatment
Authors:   Faculty of Technical Sciences, Department of Graphic Engineering and Design, Novi Sad, Serbia, Gvoić Vesna , Kerkez Đurđa ,   Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad, Serbia, Kulić Mandić Aleksandra ,   Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad, Serbia, Leovac Maćerak Anita ,   Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad, Serbia, Bečelić-Tomin Milena ,   Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad, Serbia, Tomašević Pilipović Dragana ,   Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad, Serbia, Prica Miljana ,   Faculty of Technical Sciences, Department of Graphic Engineering and Design, Novi Sad, Serbia
Published: November 2022

The paper reports removal of organic Black (Key) dye from real printing wastewater using nano zero valent iron particles as a catalyst in Fenton-like treatment. The degradation efficiency of Black diazo dye via Fenton-like treatment is reported to be 61% under established optimal process conditions: [Fe2+] = 0.75 mgL-1, pH = 2, [H2O2] = 1 mM, within a reaction time of 75 min. The absorption spectra of Black dye clearly indicate that dye degradation is a slow process with difficult decomposition of aromatic structures, due to the cleavage of diazo bonds by hydroxyl radicals. The physico-chemical characterizations (measurements of pH, electrical conductivity, temperature, turbidity, chemical oxygen demand, biochemical oxygen demand, total organic carbon, anionic surface-active substances and phosphorus content) as well as toxicity study (Vibrio fischeri bacteria) revealed the complex nature of printing effluent. Increased conductivity and biochemical oxygen demand content after Fenton treatment imply the formation of various byproducts and intermediates, formed in a solution during dye degradation. The mineralization percentage of Black dye of 58% is followed with 47% of chemical oxygen demand reduction. Results of toxicity test on Vibrio fischeri bacteria indicate that both untreated and treated printing effluents belong to moderate toxic samples with 58% and 67% of toxicity inhibition, respectively. Among three evaluated kinetic models (the first-order, the second-order, and Behnajady– Modirshahla–Ghanbary), experimental results fitted very well to the Behnajady - Modirshahla - Ghanbary model, indicating high initial rate of Black dye degradation.
Design of typeface with constructivistic properties and renovation of promotional material for memorial room
Authors:   University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Textiles, Graphic Arts and Design, Ljubljana, Slovenia, Leskovar Zalka , Pušnik Nace ,   University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Textiles, Graphic Arts and Design, Ljubljana, Slovenia
Published: November 2022

The diversity that occurs in the field of typography, more specifically in the planning and design of typefaces, plays an important role in our lives and in society more broadly. Therefore, purposeful product planning is important because it can facilitate our everyday communication and understanding of the environment. The goal of the collaborative project was to design a display typeface and use it in revised graphic products that, along with the typeface, fit the client, the Kosovel Memorial Room in Sežana, Slovenia. Srečko Kosovel is a well-known Slovenian poet whose work is representative of the cultural and social movement Constructivism. With new graphic products, we want to contribute to better publicity of Kosovel Memorial Room in Sežana. The theoretical part deals with the study and classification of typefaces in groups and larger sets. We also studied some basic properties of typefaces, contrast, stroke width and spacing, weight and height relationship within typefaces. We investigated the historical development of display typefaces, their properties, and their influence on various graphic products. Based on the content of the Kosovel Memorial Room, we examined the origin and development of the artistic avant-garde movement Constructivism abroad and in Slovenia. We highlighted important events in the life of Srečko Kosovel and familiarised ourselves with his work. Based on the client’s needs, the existing promotional material (brochure, posters, etc.) was analysed in more detail. In addition, we conceptually prepared the typeface design, drawing on his other graphic products. The display typeface was used in revised graphic products that we designed in collaboration with the client. The final products were presented in February 2022 and will continue to promote Srečko Kosovel’s work.
Legibility of typefaces and preferences of text/background color variations in virtual environment
Authors:   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Agić Ana , Mandić Lidija ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia, Stanić Loknar Nikolina ,   University of Zagreb, Faculty of Graphic Arts, Zagreb, Croatia
Published: November 2022

Text legibility is an important and influential aspect of multimedia, not only on usual multimedia reading devices (displays, tablets, and mobile phones) but also in three-dimensional virtual environments (VE). In VEs, text can be used for many purposes in accordance with the category of experience (gaming, architectural visualization, exhibition, education). Font type used can deteriorate the VE experience if the user has to strain his eyes so that he may correctly read what has been written. The purpose of this research is to examine different fonts in order to determine which properties of a typeface are more suitable for VE. Four different fonts have been tested in 10 font sizes at three viewing distances (5, 10, and 15 meters). Times New Roman as a representative of serif fonts, Helvetica as a non-serif font, Caveat as a representative of handwritten fonts, and Roboto as a font for digital use, initially developed for the Android operating system. Different typographic characteristics of fonts significantly affect readability in VE. Additionally, was explored how the color of the text and the background color influence text readability in 20 combinations. It is known that the relationship between text color and background color affects readability. Since VR is a relatively new medium, we wanted to determine which relationship between colors of text and background is the best and whether it follows some rules present on the web. The colors of the text were black and white, and the colors of the background were black, white and gray, red, green, pastel green, blue, pastel blue, yellow, pastel orange, and pastel pink. Results regarding text color/background color have shown that most participants preferred black text on white background, black text on a gray background, and white text on a pastel orange background. On the contrary, participants rated white text on a yellow background as the least preferable combination, accompanied by white text on a pastel green background.
The importance of data analysis in the modern era of print production
Authors:   HELGRAMED - The Hellenic Union of Graphic Arts & Media Technology Engineers, Athens, Greece, Trochoutsos Christos ,   Hellenic Open University, School of Applied Arts, Patras, Greece,   PressiousArvanitidis printing company, Greece, Sofias Yannis ,   University of West Attica, Greece
Published: November 2022

As the role of digital transformation becomes multi-fold in every sector, it generates huge amounts of information that can yield valuable insights at all fields of business and production activity. This has led to an expansion regarding the necessity of data handing and processing. Industry 4.0 is the current trend on automation and data exchange in manufacturing technologies. The elements that are included in Industry 4.0 create the so-called "smart factory" concept which indicates the direction towards the total transformation processes for all industries. Data analytics, following data collection, storage and handling, has become a crucial component of any business management system as an integral tool for creating strategies in all major organizations. The printing industry -of course- is not an exception to this rule. Analytic tools are embedded in all major MIS (Management Information Systems) and data are collected throughout the production from prepress to postpress departments. The present paper investigates the structure and formation of data from print management and production and the way that these can be used for providing actual and accurate information for the total business operation of a printing company.
The influence of the surrounding space on the lighting conditions in a photographic scene
Authors:   University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Textiles, Graphic Arts and Design, Chair of Information and Graphic Arts Technology, Ljubljana, Slovenia, Štampfl Veronika , Ahtik Jure ,   University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Textiles, Graphic Arts and Design, Chair of Information and Graphic Arts Technology, Ljubljana, Slovenia
Published: November 2022

Lighting conditions are one of the most important factors for good photographic exposure. In enclosed spaces, like a photography studio, we can control the light in several ways. We can adjust the type of light source, the shape of the light source, its intensity, and in some cases the colour temperature of the emitted light. The distance of the light source from the observed photographic scene affects the amount of light that reaches the desired target, and therefore the actual lighting conditions on the photographic scene. However, the environment surrounding the photographic scene is often overlooked. The light emitted interacts not only with the objects within the photographic scene, but also with any obstacle in the path upon which a light ray falls. Light rays can be reflected, partially reflected, absorbed, or scattered from any surface in the immediate vicinity of the scene, depending on the material properties of the objects they encounter. In the case of reflection, the observed scene is additionally illuminated by the reflected light, since the reflecting surface in the near environment acts as another light source. Lightabsorbing surfaces, on the other hand, do not affect the scene in the same way, since the light is absorbed and not multiplied by the reflection. Reflections from the surrounding environment can therefore affect the intended lighting conditions of the observed scene in ways that we did not anticipate. This study focuses on the influence of the surrounding space on the lighting conditions in an observed photographic scene by comparing the lighting situations in a scene from a photographic studio with a diverse environment and from a darkroom with minimal environmental influence. Halogen, LED, and xenon light sources are tested individually, illuminating the test scene with different intensities and colour temperatures. The illumination conditions at the observed photographic scene are described using spectrophotometric methods and image analysis to numerically describe the differences in uniform illumination of the flat scene surface. The results are analysed and compared to illustrate the influence of the surrounding space. Based on the results, guidelines for a suitable test environment in photographic research are proposed.
Facilitating Cross & Beyond Course Project-Based Software Engineering Learning Experiences
Authors: Maciag Tim
Published: November 2022

Throughout each academic semester, software engineering students are often provided with opportunities to explore open-ended project-based activities. Within the confines of specific courses, many of these explorations have resulted in interesting and impactful, partially or fully engineered software solutions. However, after student-developed solutions are explored, tested, and delivered within a classroom setting it has been the author’s experience that they often don’t progress beyond the course in which students explored and created them in. The results of this are missed opportunities for innovation as well as missed opportunities for further creative and collaborative explorations. This work-in-progress explores the following question: what could a model, process, and/or framework look like that would enable software engineering educators to create a learning environment that facilitates continued exploration, collaboration, and iteration of project-based student work beyond individual courses? This paper will describe an exploratory hybrid framework called ORhiDeCy that the author has designed and has been exploring in his courses over the last several years. This paper describes ORhiDeCy, an example of its successful use in the author’s software engineering teaching practice, collaborator and student feedback, and the author’s reflections and ideas for continued explorations.
Undergraduate Mentors’ Perspectives on Equity-Oriented STEM Outreach
Authors: Sutherland Callum , Mohammadi Aida , Harris Jeffrey
Published: November 2022

This paper explores undergraduate mentors’ perspectives on, and participation in, “Bringing STEM to Life: Work Integrated Learning in Physics” (BSTL), a work-integrated, equity-oriented STEM outreach program administered by the kindergarten to industry (k2i) academy at York University’s Lassonde School of Engineering. To that end, this study brings Feminist Science and Technology Studies and critical pedagogy to bear on a three-phase methodological approach to generating and analyzing qualitative data pertaining to the mentorship component of BSTL. Preliminary findings suggest that (1) undergraduate mentors bring complex STEM motivations, shaped by intersecting marginalized identities, to bear on their mentorship duties; (2) mentors possess nuanced yet occasionally contradictory understandings of STEM, equity, and society; and (3) mentors’ experiences in the BSTL program are variable but positive. These findings suggest that outreach programs can expand their capacity to generate equitable outcomes by actively supporting the creation of STEM counterspaces, foregrounding equity training, and exposing mentors to critical theoretical perspectives on STEM, equity, and society.
Benefits of Transitioning from Paper-Based to Online Assignments in Problem Solving Courses
Authors: Hosseini Ali , Ferguson Caroline
Published: November 2022

Students registered in numerical-based problem-solving courses are often given a number of assignments to complete independently in order to demonstrate and refine their problem-solving skills. Traditionally, these assignments are paper-based and all students receive the same problems to solve; thus, they often rely heavily on their peers or on solution manuals to complete their assignments. As a result, assignment grades are typically high, but do not correlate with test or exam performance.

In this paper, we describe the use of Numbas, an open educational resource created by the University of Newcastle, England, as a customizable, online assignment system. Using Numbas, each student is provided with a unique set of problems, each with randomly generated values. While they are still allowed to work collaboratively with their peers, this randomization encourages students to develop their critical thinking skills to solve unique problems. To identify if the use of the online assignment system is correlated with enhanced performance, final exam grades earned by students who were exposed to either the paper-based or the online assignment system were compared.

Furthermore, data from student feedback surveys were analyzed to identify student-perceived strengths and challenges associated with the online assignment system, and to determine possible opportunities for improvement. The study demonstrated an improvement in knowledge-based skills among students who were exposed to the online assignment system, compared to those who wrote paper assignments. However, no significant improvement in problem-solving skills was observed. Similar findings have been reported by other research works studied the same concept. Further, 88% of students surveyed reported that the online assignment system improved their learning experience.
Designing a copper mineral processing plant in virtual reality: A new tool for mining engineering education
Authors: Gibson Charlotte , Chabot Michael , Law Janice , Thoms Matthew , Moozeh Kimia , Blais Derek , Marleau Paul
Published: November 2022

In 2021, Queen’s University partnered with BBA Engineering Consultants to build a full-scale, virtual reality copper sulphide mineral processing plant. This project, financially support by e-Campus Ontario, aims to prepare Ontario post-secondary institutions to increase their training capacity in mineral processing to meet projected labour demands.
The tool includes an environment where engineering students can work in real-time to diagnose problems in a high-fidelity and safe manner using virtual reality to sharpen real-life problem solving and design skills, so students are workplace-ready for employment in the mining industry.
This paper examines the design process beginning with conceptual design, through detailed design and pilot testing. Various aspects of the project are discussed, including the agile project management approach, the importance of considering pedagogical objectives early in the project, the value of partnering with industry, and plans for further development of the tool.
INFORMING TEAM DYNAMICS OF CAPSTONE PROJECTS USING PEER EVALUATION SCORES
Authors: Li S. , O'Neill T. , Brennan R. , Gress G. , Ebufegha A.J. , Lee M.
Published: November 2022

To assess the quality of teamwork, the peer evaluation tool developed by the Individual and Team Performance (ITP) Lab has been applied in a capstone design course.  While this tool can evaluate the team skills of individual students, this paper tries to further examine the overall team dynamics through peer evaluation scores. As a result, three analyses are proposed: threshold analysis for low-score detection, comparative analysis for interpersonal comparison and conflict analysis for team conflict.  Different team profiles (e.g., a disengaged member, a dominating member and a split team) are set for numerical study, which demonstrates and examines the effectiveness of the proposed analyses.  While peer evaluation scores can be used to identify different team dynamics, further empirical study is important to relate numerical analyses for real cases.
Access site complications of manual compression versus closure devices after lower limb revascularization: a systematic review
Authors: Alabduljabbar Maitham , Alhamdan Bader , Alabdrabalnabi Mustafa
Published: November 2022

Annually, around 7 million percutaneous procedures are performed worldwide. However, the common femoral artery is still utilized for most of them, despite radial access becoming increasingly prevalent. This is an updated systematic review of studies discussing access site complications of manual compression versus closure devices after lower limb (LL) revascularization between 2017 and 2022. The PubMed and Google scholar databases were used to explore studies regarding our subject. The keywords included "access site, complications, manual compression, closure devices, LL, and revascularization" and were used in various combinations. The inclusion criteria were original studies that reported the access site complications of manual compression (MC) versus closure devices after LL revascularization and full-text- articles. Though 300 articles were obtained, only 7 of them met the inclusion criteria. The studies included 85,806 participants; 5 were prospective, 1 retrospective study, and 1 multicenter randomized clinical trial. The present systematic review indicated that vascular closure devices (VCDs) were independently related to forming fewer hematomas when MC and VCD were compared. Percutaneous endovascular operations' feasibility, safety, and efficacy were excellent, with very little conversion and complication. Lesion therapy was technically successful in 98.2% and 100% of cases. When patients were undergoing endovascular revascularization of the LL s, FemoSeal® was recommended as the first-line hemostasis treatment. Technically, VCD interventions were successful for both FS and PG patients, and hemostasis was accomplished with complete success. EXOSEAL arm has a greater success rate. The combination treatment of two VCDs with routine ultrasonography guiding access showed excellent efficacy and safety results for individuals who underwent the endovascular treatments operation.
Biotechnological research in the development of a functional product with a probiotic component
Authors: Lavrentiev M. А. , Kaliuzhnaia O. S. , Khokhlenkova N. V. , Dvinskykh N. V.
Published: November 2022

Aim. To develop the composition of a functional fermented product for therapeutic and preventive nutrition based on propionic acid bacteria enriched with carbohydrate-containing component – honey.
Materials and methods. The study objects were a lyophilized starter of propionic acid bacteria (Propionibacterium freudenreichii subsp. shermanii), milk, honey and samples of a functional fermented product made on the basis of these components. We used physico-chemical methods (determination of titrated acidity; pH determination), microbiological methods (Koch cup method; Gram stain), technological methods (determination of the syneresis degree), and organoleptic methods (the sensory profile) in our study. The statistical processing of results was carried out using the Excel software for Windows.
Results and discussion. During the experimental studies it was found that the required amount of the sowing material (starter) to obtain a product of the proper quality should be 3.75 % of the amount of the raw material (propionic acid bacteria – 106 CFU/ ml). It was proven that the optimum parameters of the main biotechnological stage of the drink preparation process were: temperature – 30 °С, time – 12 h, conditions – anaerobic. It was shown that adding 5 % of honey improved the organoleptic, physico-chemical parameters of the product, increased its biological value and reduced the time of the technological process.
Conclusions. According to the results of the technological, physico-chemical, microbiological tests the composition of the fermented product based on propionic acid bacteria enriched with honey has been developed. The product developed meets the nutritional needs and is an additional source of biologically active substances; it will increase the immune status of the body and contribute to improving its overall health.
The anticonvulsant effect of digoxin on basic models of primary generalized seizures does not depend on the route of administration
Authors: Tsyvunin V. V. , Shtrygol’ S. Yu. , Mishchenko M. V. , Shtrygol’ D. V.
Published: November 2022

Improving the prevention and treatment of epilepsy is one of the urgent tasks. Based on the available data on the anticonvulsant activity of the cardiac glycoside digoxin, it is advisable to compare the anticonvulsant effect of the drug by different routes of administration in the experiment.
Aim. To determine the impact of the route of administration on the anticonvulsant effect of the cardiac glycoside digoxin on basic models of primary generalized seizures induced by pentylenetetrazol and maximal electric shock.
Materials and methods. Two basic models were used: the model of primary generalized convulsions induced in mice by pentylenetetrazol (80 mg/kg subcutaneously) and maximal electric shock (current strength – 50 mA, frequency – 50 Hz, 0.2 sec corneally). Digoxin was administered in the dose of 0.8 mg/kg (about 1/10 LD50) 30 min before modeling seizures in the stomach and subcutaneously. Standard parameters of convulsive syndrome severity and mortality were recorded.
Results and discussion. In both seizure models, the anticonvulsant effect of digoxin was little dependent on the route of administration. In the pentylenetetrazole-induced model, with both routes of administration, lethality tended to decrease; when administered intragastrically, digoxin statistically significantly reduced the number of clonic-tonic seizures per 1 mouse, the number of animals with the most severe tonic seizures, and the duration of the convulsive period; when administered subcutaneously, it significantly increased the latent period of seizures and reduced the number of animals with tonic seizures. In the model of maximal electric shock, digoxin reduced seizure severity andlethality almost equally by both routes of administration (by 55 % with the intragastric administration and by 67.5 % with the subcutaneous administration). In both models, there were no statistically significant differences in the course of seizures in both routes of the digoxin administration. With subcutaneous administration, the anticonvulsant effect was somewhat more pronounced at the level of a weak tendency.
Conclusions. The anticonvulsant effect of digoxin when administered intragastrically and subcutaneously in mice with models of pentylenetetrazole-induced seizures and maximal electric shock is practically independent of the routeof administration. Digoxin has a pronounced anticonvulsant effect on the model of electrically induced seizures, and a moderate effect on the model of pentylenetetrazole seizures.
PENGARUH INTEGRASI INFORMASI DAN PENGAMBILAN KEPUTUSAN KOLABORATIF TERHADAP KINERJA LAYANAN LOGISTIK PADA PT. WAHANA LOGISTIK
Authors: Akbar Evan , Widowati Dorina
Published: November 2022

PT. Wahana Logistik bertujuan membangun hubungan jangka panjang dengan semua pelanggan dan memberikan kepuasan kepada pelanggan melalui keunggulan pekerjaan, agar tercapainya keunggulan pekerjaan dibutuhkan kepemimpinan yang dapat memberikan dampak kepada karyawan sehingga karyawan yang memiliki integritas dalam bekerja. Maka penting bagi PT. Wahana Logistik Persada untuk meningkatkan Kinerja Layanan Logistik menjadi lebih baik lagi. Menurut Lai et al., (2020) dalam meningkatkan Kinerja Layanan Logistik dipengaruhi oleh Integrasi Informasi Internal, Integrasi Informasi External dan Pengambilan Keputusan Kolaboratif.Penelitian ini berjudul pengaruh integrasi informasi dan pengambilan keputusan kolaboratif terhadap kinerja layanan logistik pada PT Wahana Logistik. Data yang digunakan dalam penelitan ini adalah karyawan PT Wahana Logistik. Jumlah data yang diambil pada penelitian ini terdapat 180 sampel. Variabel independen dalam penelitian ini adalah Integrasi Informasi. Variabel dependennya adalah Pengambilan Keputusan Kolaboratif. Hasil penelitian ini menunjukan bahwa terdapat pengaruh positif Integrasi Informasi Internal, Integrasi Informasi External, Pengambilan Keputusan Kolaboratif terhadap Kinerja Layanan Logistik
GREEN MARKETING MIX BERPENGARUH TERHADAP KEPUTUSAN PEMBELIAN PRODUK PLASTIK BERBAHAN SINGKONG
Authors: Pardede Matthew bonardo , Risqiani Renny
Published: November 2022

Penelitian ini dilakukan untuk Pengaruh  Green Marketing Mix terhadap Keputusan PembelianProduk Plastik Berbahan Dasar Singkong. Latar belakang penelitian difokuskan pada topik pemasaran produkplastik Telobag dalam pengunaan khususnya plastik menggunakan prinsip gelatinisasi yang didalamnya terdapatpati yang memiliki kandungan air tinggi yang tidak berbahaya bagi kesehatan dan lingkungan dalam memberikanmanfaat pada konsumen dalam berbelanja. Data dalam penulisan ini didapatkan dari sumber primer dengan caramenyebarkan kuesioner yang diisi oleh pekerja,mahasiswa dan wiraswasta yang dalam berbelanja menggunakanplastic daur ulang. Metode pengumpulan sample yang digunakan dalam penilitian ini adalah non probability sampling dengan jumlah 105 sample. Teknik yang digunakan untuk menganalisis data pada penelitian ini adalahuji instrumental seperti validitas dan reliabilitas serta uji analisis data dengan metode regresi berganda denganSPSS 24 dan AMOS 25. hasil penelitian ini membuktikan bahwa produk quality berpengaruh positif  terhadapPurchase Intention, Price Sensitivity berpengaruh positif terhadap Purchase Intention, Brand Awarnessberpengaruh positif terhadap Purchase Intention. Dari hasil penelitian ini menunjukkan bahwa Perusahaan telobag dalam produk plastik daur ulang harus memperhatikan kualitas plastic atau product quality berbahandasar pati, price sensitivity telobag lebih disesuaikan pada daya beli konsumen pengguna plastic daur ulangberbahan dasar pati serta brand awareness produk plastic daur ulang Telobag dalam memngembangkan segi peningkatan perhatian pada penggunaan pada konsumen.
OPTIMIZING BUSINESS PERFORMANCE IN PROPERTY MANAGEMENT WITH GREEN BUILDING EVIDENCE IN INDONESIA
Authors: Samosir David Kiki Baringin MT
Published: November 2022

Indonesia has not widely implemented green buildings although such buildings offer many benefits to their occupants and property management firms. In this respect, this study seeks to test the effect of green buildings on business performance. This research expands GBCI’s green building indicators with an indicator of continuous and design process to operationalize the green building variable. Meanwhile, the measurement of business performance refers to the balanced scorecard for sustainability (BSCS) concept that adds the environmental perspective into the conventional BSC. Surveying 126 manager respondents representing 89 green and non-green buildings, the study finds that green building implementation positively affects business performance. Thus, our hypothesis is empirically supported.
INDICATOR DEVELOPMENT AND QUALITY OF CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE FOR THE MINING INDUSTRY IN INDONESIA (Qualitative Study During Observation Period 2017-2019)
Authors: Setiawan Temy , Jonathan Nicholas , Kurniawati Kurniawati
Published: November 2022

Disclosure of corporate social responsibility (CSR) is increasing in urgency because demands for legitimacy are increasing. Companies can disclose their CSR through annual reports or sustainability reports. This study aims to provide information on how many companies have disclosed CSR in their sustainability reports, the average extent of disclosure in annual reports and sustainability reports, which indicators are predominantly disclosed and which disclosures are limited. This research is a descriptive qualitative study using secondary data taken from the website company's official in the form of an annual report and a sustainability report and then analyzed by reference to the GRI-G4 and/ or GRI-standards using quantitative and qualitative content analysis techniques. The result of the research is that the company disclosure of CSR using sustainability reports is only 20%; and the rest is still in the annual report. General indicators disclosed based on GRI-G4 and GRI-standard are positive and non-monetary disclosures, especially on sensitive indicators because they are private to the company. This study also provides a qualitative measurement (measurement of variety) of CSR disclosure involving tables/ photos/ diagrams in addition to general narrative disclosures in quantitative content analysis techniques as a new measurement nowadays. Keywords: GRI-Standard; GRI-G4; CSR disclosure, a qualitative content analysis technique
TATA KELOLA PEMERINTAHAN PUSAT DALAM PENGEMBANGAN KABUPATEN TAPANULI UTARA
Authors: Purba Sahala , Purba Kuras
Published: November 2022

Riset ini bermaksud untuk mengevaluasi apakah pengembangan Kabupaten Tapanuli Utara yang terletak di Provinsi Sumatera Utara berhasil atau tidak ditinjau dari analisis laporan keuangan pemerintah daerah dari 8 aspek pengukuran antara lain: Proporsi Otonomi Finansial Daerah, Proporsi Ketidakmandirian Finansial Daerah, Proporsi Ukuran Desentralisasi Fiskal,  Proporsi Keefektifan PAD, Proporsi Keefisienan PAD, Proporsi Keefektifan Pajak Daerah, Proporsi Keefisienan Pajak Daerah dan Proporsi Ukuran Sumbangan BUMD. Riset ini adalah riset deskriptif kuantitatif dengan Subjek Riset informasi Finansial pemerintah daerah selama tahun 2013-2020, dan objek riset Informasi Realisasi Anggaran, Neraca, dan Informasi Rincian Penerimaan PAD Kabupaten. Teknik pengumpulan data yang dipakai adalah metode dokumentasi.  Teknik  analisis  data  yang dipakai adalah analisis proporsi finansial. Hasil riset menunjukkan, dari 8 (delapan) proporsi pengukuran analisis laporan keuangan pemerintahan daerah terdapat kabupaten Pakpak Barat mengalami kegagalan dalam pengembangan ditinjau 5 (lima) proporsi yaitu Proporsi Otonomi Finansial Daerah, Proporsi Ketidakmandirian Finansial Daerah, Proporsi Ukuran Desentralisasi Fiskal,  Proporsi Keefisienan PAD, Proporsi Keefisienan Pajak Daerah, sedangkan kabupaten Toba hanya memiliki kelemahan pada Proporsi Ukuran Desentralisasi Fiskal, Kabupaten Humbang Hasundutan hanya lemah pada Proporsi Keefektifan PAD sedangkan Kabupaten Samori lemah dari Proporsi Ukuran Sumbangan BUMD, berarti bisa diambil kesimpulannya secara keseluruhan pemerintah pusat telah berhasil melakukan pengembangan Kabupaten Tapanuli Utara.
Case report and review of the literature of primary central nervous system lymphoma of the fourth ventricle
Authors: Kojima Yuichiro , Nakajo Kosuke , Ichinose Tsutomu , Morikawa Yoichiro , Osawa Masahiko , Goto Takeo
Published: November 2022

Background:

Primary central nervous system lymphoma of the fourth ventricle is very rare. We present a case of primary central nervous system lymphoma originating from the fourth ventricle and review cases reported in the literature.

Case Description:

A 54-year-old man with no previous medical history presented with headache and nausea. Magnetic resonance imaging showed a homogeneously enhancing tumor in the fourth ventricle and obstructive hydrocephalus. We performed biopsy of the tumor, which was diagnosed pathologically as diffuse large B-cell lymphoma. Although the tumor disappeared after 5 cycles of R-MPV regimen, the patient required repeated ventricular drainage and finally received a ventriculoperitoneal shunt. Complete response was achieved after 2 cycles of high-dose cytarabine chemotherapy with an autologous peripheral blood stem cell transplant. There was no sign of recurrence at 20 months after biopsy.

Conclusion:

Morbidity arising due to radical resection/radiotherapy of resistant primary central nervous system lymphoma originating from the fourth ventricle could be prevented by ventriculoperitoneal shunting with chemotherapy and autologous blood stem cell transplantation.
Distributive Nd-to-Yb Energy Transfer within Pure [YbNdYb] Heterometallic Molecules
Authors: Roubeau Olivier , Settineri Nicholas S. , Guyot Yannick , Riobé François , Maury Olivier , Abad Galán Laura , Aromi Guillem , Aguilà David , Barrios Leoní A. , Sickinger Annika , Maniaki Diamantoula
Published: November 2022

Facile access to pure heterolanthanide molecules will open new avenues in the search of novel photophysical phenomena based on Ln-to-Ln’ energy transfer (ET). This challenge demands strategies to segregate efficiently different Ln metal ions among different positions in a molecule. We report here the one-step synthesis and structure of a pure [YbNdYb] (1) coordination complex featuring short Yb···Nd distances, ideal to investigate a potential distributive intramolecular ET from one Nd3+ ion to two Yb3+ centers within a well characterized molecule. The difference in ionic radius is the mechanism allowing to allocate selectively both types of metal ion within the molecular structure, exploited with the simultaneous use of two β-diketone type ligands. To assist the photophysical investigation of this heterometallic species, the analogues [YbLaYb] (2) and [LuNdLu] (3) have also been prepared. Sensitization of Yb3+ and Nd3+ in the last two complexes, respectively, was observed, with remarkably long decay times, facilitating the determination of the Nd-to-Yb ET within the [YbNdYb] composite. This ET was demonstrated by comparing the emission of iso-absorbant solutions of 1, 2 and 3 and through lifetime determinations in solution and solid state. The comparatively high efficiency of this process corroborates the facilitating effect of the double channel for the non-radiative decay of Nd3+ created within the [YbNdYb] molecule.
Solid-phase synthesis of cereblon-recruiting selective histone deacetylase 6 degraders (HDAC6 PROTACs) with anti-leukemic activity
Authors: Sinatra Laura , Yang Jing , Schliehe-Diecks Julian , Dienstbier Niklas , Vogt Melina , Gebing Philip , Bachmann Luisa M. , Sönnichsen Melf , Lenz Thomas , Stühler Kai , Schöler Andrea , Borkhardt Arndt , Bhatia Sanil , Hansen Finn K.
Published: November 2022

In this work, we utilized the proteolysis targeting chimera (PROTAC) technology to achieve the chemical knock-down of histone deacetylase 6 (HDAC6). Two series of cereblon-recruiting PROTACs were synthesized via a solid-phase parallel synthesis approach, which allowed the rapid preparation of two HDAC6 degrader mini libraries. The PROTACs were either based on an unselective vorinostat-like HDAC ligand or derived from a selective HDAC6 inhibitor. Notably, both PROTAC series demonstrated selective degradation of HDAC6 in leukemia cell lines. The best degraders from each series (denoted A6 and B4) were capable of degrading HDAC6 via ternary complex formation and the ubiquitin−proteasome pathway, with DC50 values of 3.5 and 19.4 nM, respectively. PROTAC A6 demonstrated promising antiproliferative activity via inducing apoptosis in myeloid leukemia cell lines. These findings highlight the potential of this series of degraders as effective pharmacological tools for the targeted degradation of HDAC6.