bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of prognosis of Pancreatic adenocarcinoma based on anoikis-related genes and Multi-omics Verification
Authors: Zhang Jin , Li Xuesong , Zhang Zhongmin , Shen Yuxiang , Li Guanghao , Wang Guowen , Duan Yuansheng
Published: December 2022

Background
Anoikis is a specific form of apoptosis caused by the detachment of cells from the extracellular matrix. Several studies have reported that anoikis-related genes played an important role in the development of cancer.
Methods
Univariate Cox regression analysis and lasso regression analysis for anoikis-related genes were utilized to establish a prognostic model for pancreatic adenocarcinoma in the TCGA database. We also performed univariate and multifactorial Cox analyses of protein sequencing results for TCGA pancreatic adenocarcinoma. We then performed a cluster analysis based on prognostic model genes and explored the somatic mutations in various types of patients. Besides, we explored the difference in immune infiltration between the high-risk and low-risk groups. At last, the expression of screened genes was verified by real-time quantitative PCR (qRT-PCR).
Results
We found that many anoikis-related genes are associated with pancreatic adenocarcinoma prognosis. Finally, we screened seven genes (MET, DYNLL2, CDK1, TNFSF10, PIP5K1C, MSLN, GKN1). We also found that EGFR and MMP2 proteins have an important impact on the prognosis of pancreatic adenocarcinoma. According to the seven prognostic gene clustering analyses, it can be clearly divided into three categories, and the somatic mutations of patients in the three categories differed significantly. There was also a significant difference between the high-risk and low-risk groups in terms of immune infiltration. All genes were are highly expressed in tumor cells (AS, CF) than that in normal cell (HPDE).
Conclusion
Through our study, we found that anoikis had a very important effect on the development of pancreatic adenocarcinoma. Our prognostic model based on seven anoikis-related genes has good predictive performance. KRAS, P53 and CDKN2A mutations also have important effects on the prognosis of pancreatic adenocarcinoma.
Health Promotion and Disease Prevention Registries in the E.U.: A cross country comparison
Authors: Rossmann Christin , Krnel Sandra Radoš , Kylanen Marika , Lewtak Katarzyna , Tortone Claudio , Ragazonni Paola , Grasso Mara , Maassen Alison , Costa Luciana , Dale Djoeke van
Published: December 2022

Background: Health promotion and disease prevention programme registries (HPPR), or ‘best practice portals’, serve as entry points and practical repositories which enable decision-makers to have easy access to (evidence-based) practices. However, there is limited knowledge of differences or overlaps in the functioning of current national HPPRs in Europe, the context and circumstances in which these HPPRs were developed, and the mechanisms utilised by each HPPR for assessment, classification and quality improvement of included practices.
The aim of the study was to prepare an overview of different approaches in several national HPPRs and the EU Best Practice Portal (EU BPP) as well as to identify commonalities and differences among core characteristics of the HPPRs.
Methods: A descriptive comparison – focused on six European countries with an existing or recently developed/implemented national HPPR and the EU BPP – was conducted to create a comparative overview. Coding mechanisms were used to identify commonalities and differences, and data management, collection and building consensus were performed during EuroHealthNet Thematic Working Group meetings.
Results: All HPPRs offer a broad range of health promotion and disease prevention practices and are designed to support practitioners, policy makers and researchers in selecting practices. Almost all HPPRs have an assessment process in place or planned, requiring the application of assessment criteria that differ among the HPPRs. While all HPPRs collect and share recommendable practices, others have implemented further measures to improve the quality of submitted practices. Different dissemination tools and strategies are employed to promote the use of the HPPRs, including social media, newsletters and publications as well as capacity building workshops for practice owners or technical options to connect citizens/patients with local practices.
Conclusions:
Collaboration between HPPRs (at national and EU levels) is appreciated, especially in terms of using consistent terminology to avoid misinterpretation and facilitate cross-country comparison, as well as to facilitate discussion on the adaption of assessment criteria by national HPPRs. Greater efforts are needed to promote the actual implementation and transfer of practices at national level in order to address public health challenges with proven and effective practices.
Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil activation
Authors: Selldén Tilia , Mårdh Carina Kärrman , Joelsson Martin , Vikgren Jenny , Johnsson Åse , Larsson Gunilla , Glinatsi Daniel , Stubendorff Kajsa , Svensson Karin , Gjertsson Inger , Rudin Anna , Lundell Anna-Carin , Ekwall Anna-Karin Hultgård
Published: December 2022

Background:
The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop severe treatment resistant lung disease. Understanding early disease mechanisms is of great importance. The objective of this study was to determine whether there is an association between peripheral neutrophil phenotypes and presence of pulmonary abnormalities (PA) on chest high-resolution computed tomography (HRCT) in untreated early RA (ueRA).
Methods:
Clinical data and blood were collected, and HRCT performed at diagnosis on 30 consecutive anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) positive ueRA patients. HRCTs were evaluated for the presence and extent of RA-associated parenchymal, airway and/or pleural abnormalities. Expression of phenotype markers on neutrophils were determined by flow cytometry. Levels of calprotectin, ACPA and RF were measured using immunoassays.
Results:
The frequency of having any PA was 60%. Airway abnormalities were present in 50%, parenchymal nodules in 43% and interstitial lung abnormalities (ILA) in 10%. Unsupervised multivariate factor analysis showed clustering of any PA with neutrophil activation, parameters of inflammation and RF titres. In univariate analysis, the patients with PA displayed significantly increased CD11b and decreased CD62L expression on neutrophils (1.2-fold, p = 0.014; 0.8-fold, p = 0.012) indicating activation, and significantly increased RF IgM titre and CRP (5.7-fold, p = 0.0025; 2.3-fold, p = 0.0035) as compared to no PA. Titres of RF, but not ACPA, correlated with expression of the neutrophil activation marker CD11b. A stratified analysis demonstrated that airway involvement was the PA subtype with the strongest association with neutrophil activation.
Conclusion:
We report a strong association between radiographic airway findings and activation of circulating neutrophils in early RA supporting a role of innate immunity and the lung in disease onset. Our results also indicate different contributions of RF and ACPA in the RA pathogenesis.
Further variation of the adulticide protocol for the treatment of canine heartworm infection: Can it be even shorter and cost less?
Authors: Ward Karen Ann , Jacobson Linda Susan , Lacaden Aveline Baldasan , Harrison Kelly Ann
Published: December 2022

Background

This retrospective study evaluated modified 3-dose melarsomine treatment protocols in a shelter setting and compared them to the American Heartworm Society (AHS) recommended protocol.

Methods

As compared to the AHS protocol, the shelter protocols utilized doxycycline 10 mg/kg once daily (SID) or twice daily (BID), and varied the time from initiation of doxycycline (day 1) to the first melarsomine injection (M1). Dogs were retrospectively grouped based on the shelter’s current protocol (M1 on day 14; Group A) and the AHS protocol (M1 on day 60; Group C), allowing a week on either side of the target M1 day. Treatments that fell outside of these ranges formed two additional treatment groups (Groups B and D). Respiratory complications were defined as respiratory signs requiring additional treatment, and were statistically compared for Groups A and C. New respiratory signs and gastrointestinal (GI) signs were compared between dogs receiving SID or BID doxycycline.

Results

One hundred fifty-seven dogs with asymptomatic or mild heartworm disease at presentation were included. All dogs survived to discharge. There was no statistically significant difference between Groups A (n = 79) and C (n = 27) for new respiratory signs post-melarsomine (P = 0.73). The time to M1 for 14 dogs that developed new respiratory signs was median 19 days, compared with 22 days for 143 dogs without new respiratory signs (P = 0.2). Respiratory complications post-melarsomine were uncommon. New respiratory signs post-melarsomine occurred in 10/109 (9.2%) dogs receiving SID doxycycline and 4/48 (8.3%) dogs receiving BID doxycycline (P > 0.999). GI signs prior to M1 were recorded for 40/109 (36.7%) dogs receiving SID doxycycline and 25/48 (52.1%) receiving BID doxycycline (P = 0.08). Forty-four follow-up antigen test results were available; all tests performed > 3 months after the third melarsomine injection were negative.

Conclusions

This study provided support for initiating melarsomine after 14 days of doxycycline and for a lower doxycycline dose. Shorter and less expensive treatment protocols can increase lifesaving capacity and improve quality of life for shelter dogs by reducing the duration of exercise restriction and length of stay.
Comprehensive benefits evaluation of highway sand control engineering based on matter-element extension model with variable weight
Authors: LI Liangying , LV Lele , YIN Wenhua , TAO Zhizhong , LI Qi
Published: December 2022

A scientific and reasonable sand control engineering can effectively reduce the impact of wind and sand activities on highway. The accurate evaluation of the comprehensive benefits about sand control engineering is the key to judging whether they can achieve the expected protective effect and ensure the smooth operation of desert highway. Through literature surveys and integrated analysis of typical highway sand control engineering in desert areas, a comprehensive benefits evaluation indicator system for highway sand control engineering was constructed from three dimensions: engineering benefits, economic benefits and environmental benefits. Then, the matter-element extension model with variable weight was introduced to calculate the indicator weights and a comprehensive benefit evaluation model for sand control engineering was proposed. The model allows the problem of distortion in evaluation result due to fluctuations in indicator values to be resolved. Combined with sand control engineering in the desert section of the Wuhai-Maqin Highway in China, the verification of the evaluation results was implemented. The research results show that the comprehensive benefits of the sand control engineering in the desert section of the Wuhai-Maqin Highway is in the “good” level, but it is slightly inclined towards the trend of the “medium” level. In this case, the ability to resisting wind and sand, construction quality and growth and restoration of vegetation, the three evaluation indicators of 13 evaluation indicators are the key indicators which make a significant impact on the comprehensive benefits. In the operation and maintenance stage, the growth and recovery ability of vegetation can be enhanced by strengthening the cultivation of vegetation, and the linkage of engineering, economy and environmental benefits can be promoted. The research results can be used as a reference for the evaluation of highway sand control engineering in wind and sand areas.
The Complete Chloroplast Genome of Endangered Species Dendrobium flexicaule: Insight into the Phylogenetic Relationship and Conservation Implications
Authors: Zhang Jie , Wang Le , Ming Xingjia , Shu Shu , Qu Xianyou , Zhang Jiayi , Liu Xue
Published: December 2022

Dendrobium flexicaule is an endangered species, listed at first-class National Key protected Wild Plant in China, narrowly endemic to China. It has a unique application different from other Dendrobium plants as a cure of infantile convulsions. Studying endangered species is helpful for current management and conservation.To compare analyze of the chloroplast genome (cp DNA) of D. flexicaule and other three related species(D. officinale, D. huoshanense, and D. moniliforme) and to analyze their chloroplast genome difference, we analyzed it from basic feature of chloroplast genome of D. flexicaule, codon usage and IR boundary, simple repeats, and phylogenetic tree, respectively. Download the chloroplast genome sequences of D. flexicaule, D. officinale, D. Huoshanense and D. moniliforme from the public database of NCBI were used to re-annotate by CPGAVAS2 software. We also constructed the MaximumLikehood phylogenetic tree using the MEGA-X tool.Comparing the IR/SC boundaries of the four Dendrobium species found that the IRb/SSC nodes of D. flexicaule and D.moniliforme expanded into the ndhF gene, while the IRb/SSC nodes of D. officinale and D. Huoshanense were between ycf1 and ndhF. The results of phylogenetic analysis show that D. flexicaule and D. officinaleare clustered together. The analysis of the cp genome of D. flexicaule provided crucial genetic information for further studies of this vulnerable species and the taxonomy, phylogenetics and evolution of Dendrobium.
System Dynamics Modeling to Compensate Co 2 Emissions in Road and Road-rail Transport Models in the Atlantic Forest Biome
Authors: Oliveira George , Silva Liniker Fernandes , Reis Leonardo Pequeno , Freitas Luís Carlos , Carvalho Jonatas Moreira Cruz
Published: December 2022

The objective of this study was to determine between the purchase of carbon credits and the activity of forest restoration in the Atlantic Forest which investment in CO2 emissions compensation is more attractive from an economic point of view and also to determine between the road and intermodal modes (road + rail) the most attractive option from an environmental point of view. To this end, a System Dynamics model was developed capable of converting CO2 emissions in restored forest areas in the Atlantic Forest biome and/or carbon credits from REDD + projects and estimating the costs associated with these offsets. The model was fed with data related to cargo transport in two modes: road and rail. For each modal, four different scenarios were developed for the offsetting of emissions: only forest plantation; only purchase of carbon credits; 50% forestry planting and 50% purchase of carbon credits; and 30% forestry planting and 30% purchase of carbon credits. The results indicate that the most attractive option from an economic point of view is the compensation of emissions through forestry planting and that the most attractive option from an environmental point of view is the use of the road-rail modal.
Existence of random mild solutions of a random integrodifferential equation with lack of compactness
Authors: El-Ghabi Adil , Khchine Abdelmjid , Taoudi Mohamed Aziz
Published: December 2022

In this paper, we show the existence of random mild solutions for a broad class of random integrodifferential equations with lack of compactness. The results are obtained using noncompact resolvent operators and a fixed point theorem of Monch type. Our results are applied to a large variety of partial differential equations in which memory effects are considered. Some examples are provided to illustrate the theoretical results.
Mathematics Subject Classification (2010). Primary 45K05, 47G20, 47D06, 47H10; Secondary 47H08.
Blockade of Erythropoietin Enhances the Abscopal Effects of Radiotherapy Restraining Lung Metastasis by Inducing an Immunopermissive Tumor Microenvironment
Authors: Liu Shin-Yi , Kuo Feng-Chi , Liou Wan-Zu , Chou Ying-Hsiang , Wu I-Fang , Lee Chi-Pin , Aicher Alexandra , Chen Yu-Jen
Published: December 2022

BackgroundDistant out-of-field, so-called abscopal, anti-metastatic effects of local radiation are rarely observed in cancer patients treated with radiotherapy alone. However, the era of immune checkpoint inhibitors (ICI) has increased abscopal effects following combinational treatment using radiotherapy and ICI (Radio-ICI). Hence, ICI-induced activation of cytotoxic T cells in the metastatic tumor microenvironment (TME) was instrumental in mediating the abscopal effect. Here, we hypothesized to improve the efficacy of abscopal effects observed in Radio-ICI through additional inhibition of immunosuppressive cells originating from the bone marrow. Therefore, we employed focal radiotherapy on the bone marrow of a single limb combined with ICI as alternative treatment for the induction of anti-metastatic abscopal responses.MethodsWe established lung metastatic mouse models by intravenous injection of colorectal cancer and melanoma cells, followed by single limb irradiation (SLI) treatment with 5 Gy to trigger abscopal effects. Tumor control, adverse effects, and composition of immune cells in the TME were monitored after radiotherapy as monotherapy or combinational therapy with ICI. Suppression of erythropoietin (EPO) using a neutralizing antibody was combined with SLI treatment to dissect the contribution of EPO signaling for the induction of abscopal effects. Functional markers for lymphoid and myeloid lineage cells, including subsets of immunosuppressive myeloid-derived suppressor cells (MDSC) and erythroid progenitor cells (EPC), were determined by flow cytometry, western blotting, and real-time PCR.ResultsSLI treatment alone induced a significant abscopal effect against lung metastases and enhanced the therapeutic efficacy of anti-PD-1. MDSC and EPC were suppressed after SLI exposure, accompanied by the reduction of M-CSF and EPO in the plasma of lung metastatic mice. Addition of EPO protein neutralized the SLI-induced antitumor response, while treatment with EPO antibody alone or in combination with SLI effectively inhibited tumor growth. Suppression of arginase 1 protein with concomitant increase of CD8 mRNA expression in the TME was observed after SLI treatment combined with EPO antibody. These effects were abrogated when SLI was combined with EPO protein.ConclusionSLI treatment induced an abscopal anti-metastatic tumor effect mitigating immunosuppressive barriers provided by MDSC and EPC, thus reversing the tumor-induced T cell dysfunction in the TME.
D3 lymph node dissection improves the survival outcome in patients with pT2 colorectal cancer
Authors: Wang Liming , Song Bolun , Chen Yinggang , Hirano Yasumitsu
Published: December 2022

Background: The extent of lymphadenectomy in patients with pT2 colorectal cancer (CRC) remains controversial. This study aimed to elucidate the effects of D3 and D2 lymph node dissection (LND) on survival in patients diagnosed with pT2 CRC.
Methods: This was a retrospective cohort study from a high-volume cancer center in Japan. From April 2007 to December 2020, 6,273 patients with primary CRC were included in the study; among these, 616 patients diagnosed with pT2 CRC underwent radical colorectal resection. Propensity score matching (PSM) was applied to balance potential confounding factors and a total of 104 matched pairs were extracted from the entire cohort. Independent risk factors associated with prognosis were determined by Cox regression analysis. The main outcome measures were overall survival (OS) and cancer-specific survival (CSS).
Results: Before PSM, there was a statistically significant difference across the cohort in OS and CSS (p=0.000 and 0.013) between D3 and D2 LND groups; the estimated hazard ratio (HR) was 2.2 (95% confidence interval (CI), 1.1-4.4, p=0.031) for OS in the D3 LND and 4.4 (95% CI, 1.7 to 11, p=0.0027) for CSS (p=0.013). There was also a significant difference (p=0.024) in OS between the D3 and D2 LND groups in the matched cohort, with an estimated HR for OS of 3.3 (95% CI, 1.2 to 9.1, p=0.024) and an estimated HR for CSS of 7.2 (95% CI, 1.6 to 33, p=0.011).
Conclusions:
D3 LND had a significant survival advantage in the treatment of pT2 colorectal cancer. The results of this study provide a theoretical basis for the application of D3 LND in radical surgery for pT2 colorectal cancer.
Copper-inducible expression system for metabolic engineering of Escherichia coli
Authors: Liu Lingrui , Zhang Lu , Wang Junyi , Cao Mingfeng , Yuan Jifeng
Published: December 2022

Background
The inducible expression system plays an important role in engineering Escherichia coli for chemical production, however, it still heavily relies on expensive chemical inducers, like IPTG. There is a pressing need to develop alternative expression systems with more affordable inducers.
Results
We herein reported a copper-induced gradient expression system in E. coli based on the two-component Cus system and T7 RNA polymerase (RNAP). By integrating the gene encoding T7 RNAP at the CusC locus, we managed to program eGFP expression under T7 promoter in response to different concentrations of Cu2+ (0–20 µM). Subsequently, we demonstrated that the copper-induced gradient expression system was suitable for metabolic engineering of E. coli towards protocatechuic acid (PCA) overproduction, and the resulting strain with combined manipulation of the central metabolism via CRISPRi produced 4.12 g/L PCA under the optimal copper concentration and induction time.
Conclusions
We established a copper-inducible T7 RNAP expression system in E. coli. The copper-induced gradient expression system could rationally control metabolic pathways in a temporal and dose-dependent manner. The gradient expression system based on copper inducer could be widely used in E. coli cell factories, and the design principle reported here would also be applicable in other prokaryotes.
Socio-Economic Impacts of FIFA World Cup Qatar 2022: A Study in Chon Buri Sports City Residents
Authors: Chankuna Dittachai
Published: December 2022

Hosting FIFA World Cup obviously produce immense socio-economic impacts to a nation. Proximal non-host city perception to mega event was frequently explored, while distal non-host city perception has less investigated. This study assessed the socio-economic impacts of FIFA World Cup Qatar 2022 in Chon Buri Sports City residents. Participants were 422 Chon Buri Sports City residents from eleven districts. Perception on socio-economic impacts of hosting FWC Qatar 2022 was measured from the translated Scale of Perceived Social Impacts. Extracted seven dimensions by confirmatory factor analysis is consistent with empirical data. Positive impact dimensions are Community Development, Community Pride, Economic Benefits. Negative impact dimensions are Traffic Problems, Security Risks, Economic Costs, and Environmental Concerns. Chon Buri Sports City residents perceived fewer negative impacts than other non-host city residents. Positive impacts of hosting FWC Qatar 2022 has more influenced on Chon Buri Sports City residents’ perception than negative impacts. These findings advantage for sport stakeholders to deeper understand the impacts of mega event hosting.
One Pattern Analysis (OPA) for the quantitative determination of protein interactions in plant cells
Authors: Maika Jan Eric , Strotmann Vivien Ingeborg , Krämer Benedikt , Wellmer Frank , Weidtkamp-Peters Stefanie , Stahl Yvonne , Simon Rüdiger
Published: December 2022

Background:

A commonly used approach to study the interaction of two proteins of interest (POIs) in vivo is measuring Förster Resonance Energy Transfer (FRET). This requires the expression of the two POIs fused to two fluorescent proteins that function as a FRET pair. A precise way to record FRET is Fluorescence Lifetime IMaging (FLIM) which generates quantitative data that, in principle, can be used to resolve both complex structure and protein affinities. However, this potential resolution is often lost in many experimental approaches. Here we introduce a novel tool for FLIM data analysis of multiexponential decaying donor fluorophores, One Pattern Analysis (OPA), which allows to obtain information about protein affinity and complex arrangement by extracting the relative amplitude of the FRET component and the FRET transfer efficiency from other FRET parameters.

Results:

As a proof of concept for OPA, we used FLIM-FRET, or FLIM-FRET in combination with BiFC to reassess the dimerization and tetramerization properties of known interacting MADS-domain transcription factors in Nicotiana benthamiana leaf cells and Arabidopsis thaliana flowers. Using the OPA tool and by extracting protein BINDING efficiencies from FRET parameters to dissect MADS-domain protein interactions in vivo in transient N. benthamiana experiments, we could show that MADS-domain proteins display similar proximities within dimeric or tetrameric complexes but bind with variable affinities. By combining FLIM with BiFC, we were able to identify SEPALLATA3 as a mediator for tetramerization between the other MADS-domain factors. OPA also revealed that in vivo expression from native promoters at low levels in Arabidopsis flower meristems, in situ complex formation of MADS-domain proteins cannot be detected.

Conclusions

We conclude that MADS-domain protein interactions are transient in situ and may involve additional, so far unknown interaction mediators. We conclude that OPA can be used to separate protein binding from information about proximity and orientation of the interacting proteins in their complexes. Visualization of individual protein interactions within the underlying interaction networks in the native environment is still restrained if expression levels are low and will require continuous improvements in fluorophore labelling, instrumentation set-ups and analysis tools.
Unveiling the gemcitabine drug complexation with cucurbit[n]urils (n=6-8): A computational analysis
Authors: Venkataramanan Natarajan Sathiyamoorthy , Suvitha Ambigapathy , Sahara Ryoji , Kawazoe Yoshiyuki
Published: December 2022

In this work, the DFT-D3 method was employed to investigate the complex formation capability of gemcitabine drug with host cucurbit[n]uril Q[n] (n = 6,7 and8) molecules. The density functional theory studies demonstrate that the most stable configuration is a fully encapsulated complex. In the gemcitabine@[6] and gemcitabine@[7] encapsulated systems the gemcitabine amino -NH2 and the alcoholic group in the carbohydrate bonds with the carbonyl units of Q[n]. The addition of sodium ions leads to the partial exclusion of the gemcitabine molecule and the sodium atoms lie close to the carbonyl portal of Q[7]. Thermodynamic parameters computed for the complexation process exhibit high negative entropy change implying that the encapsulation process is spontaneous and is an enthalpy-driven process. Frontier molecular orbitals are located mainly on the gemcitabine uracil ring, before and after encapsulation formation, indicating that the encapsulation happens by pure physical adsorption. Quantitative molecular electrostatic potentials demonstrate a shift in charge occurs during the complex formation and is more pronounced in gemcitabine@Q[7]. AIM topological analysis illustrates that these complexes are stabilized by various noncovalent interactions including HBs and C···F interactions. The 2D RDG plots exhibit the presence of strong HBs and weak van der Waals interactions and the presence of steric repulsion. The isosurface NCI diagram shows predominant steric interaction in the gemcitabine@Q[6] complex. The NCI isosurface for gemcitabine encapsulated complexes with Q[7] and Q[8] host displays that the green patches are uniformly distributed in all directions. Finally, EDA results demonstrate Paulis repulsive energy is predominant in the gemcitabine@Q[6] complex, while the orbital and dispersion energies stabilize the gemcitabine@Q[7] complex.
Exploring the dynamics of triglyceride with stroke onset in the Chinese population through parameterized joint models
Authors: Mao Qian , Gao Wenfeng , Yang Liping , Yang Yi , Xu Yaqi , Cong Huiwen , Wang Lianyuan , Shi Fuyan , Wang Suzhen
Published: December 2022

Background: Stroke has become one of the diseases with the highest mortality and disability rates in the world, especially in low-income and developing countries. Our objective was to discuss the relationship between the longitudinal dynamic changes of triglyceride and stroke onset in healthy populations by constructing different parametric joint models.
Methods: 298 participants aged 23 to 69 in Xijing hospital of Xi’an City in Shanxi Province from 2008 to 2015 were included. The Cox proportional hazards model was performed to analyze the correlation between triglyceride and stroke incidence at baseline. Different parameterized joint models were used to analyze the impact of dynamic changes of triglyceride on the incidence of stroke under longitudinal data.
Results: Of the 298 participants, a total of 70 (23.49%) subjects developed stroke during the study period. Cox proportional hazards model showed that the risk of disease increased by 1.056 times (95%CI=0.920-0.975) for each 1 unit of baseline age decrease. Each 1 mmol/L increase in sqrt(triglyceride) increased the risk by 1.816 times (95%CI=1.017-3.245). Joint model showed that the risk of sqrt(triglyceride) increased by 4.869 times (95%CI=3.987-8.857) for each 1 mmol/L increase in the longitudinal direction. The lagged effects (HR=5.284, 95%CI=4.397-9.680) and cumulative effects (HR=1.786, 95%CI=1.613-3.399) of sqrt(triglyceride) dynamic trajectory were also statistically related to the incidence of stroke.
Conclusions: Over time, the longitudinal growth of triglyceride levels in individuals will increase the risk of stroke even more. People should pay more attention to the dynamic changes of individual triglyceride values, as well as the lagged effect and cumulative effect, to reduce the incidence of stroke.
Energy-converting equipment of high-voltage spacecraft power supply systems with a digital control system
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Sukhorukov M. P.
Published: December 2022

The article presents the results of experimental studies of the experimental and known characteristics of the energyconverting equipment (EPA) of the supply system (EPS) of a spacecraft (SC) with a digital control system. The obtained results of experimental studies confirm the theoretical results obtained earlier in the development of a digital control system for the ESA of the EPS of the spacecraft.
Schottky barrier diodes based on thermally resistant Ir-GaAs and Pt/Ir-GaAs contacts created by electrochemical deposition
Authors:   Research Institute of Semiconductor Devices, Bozhkov V. G. , Bekezina T. P. ,   Research Institute of Semiconductor Devices, Burmistrova V. A. ,   Research Institute of Semiconductor Devices
Published: December 2022

The article is devoted to the study of the thermal stability of Ir-GaAs and Pt/Ir-GaAs contacts obtained by electrochemical deposition using technology developed by the authors. The choice of metallization is due to a number of reasons, which are discussed in the paper. One of the most important ones is the increased thermal stability of contacts, that enables its use in power devices of semiconductor electronics in wide frequency range. The forward and reverse current – voltage (I – V) characteristics of the contacts in the range of diameters from 500 to 5 μm and their following parameters are studied: ideality factor n, measured and effective barrier heights, reverse voltage. It has been shown that the covering of iridium with a thin layer of Pt increases its thermal stability. A peculiarity of the results is a higher thermal stability of contacts with a small diameter.
Development of gas production system survivability model in the conditions of well flooding
Authors:   Orenburg State University, Solovyov N. A. , Valeev A. F. ,   Gazprom Dobycha Orenburg
Published: December 2022

The article is devoted to the development of methodological support for an automated system that allows carrying scientific research on the survivability of flooded gas wells. A model of the gas production system survivability under conditions of well flooding is proposed. It includes a «reservoir-well» model, a model of adverse effects of flooding, a model of physical processes, a model of primary flooding consequences, a model of means of ensuring survivability, a model of the primary flooding consequences development, a calculation unit indicators of survivability and a database for working with initial data and simulation results. Based on the analysis of existing approaches to assessing the survivability of technical systems, the coefficient of gas production system survivability under flooding conditions has been developed. It depends on the properties of performance, resource intensity when using technologies to combat flooding in wells. A criterion for choosing the best means of ensuring the survivability of a flooded gas well is proposed, taking into account the parameters of the reservoir, well design and equipment, and gas flow rate.
Propagation of ultrashort pulse in a model of a turn of a microstrip line folded into a meander with guard conductors
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Surovtsev R. S. , Skornyakov I. A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Karri S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

The possibility of reduction of the required space on the PCB of a meander line turn model with the maintenance of its protective properties through the use of guard conductors is studied. As a result of quasi-static and electrodynamic simulating, regularities of USP attenuation are revealed. As a result, the possibility to reduce the width of the device by 45% of the initial one with 3 times attenuation is shown.
Development of a subsystem to use Bayesian networks in a decision support system for software development management
Authors:   National Research Tomsk State University (NR TSU), Zmeev D. O. , Zmeev O. A. ,   National Research Tomsk State University (NR TSU), Ivanova L. S. ,   National Research Tomsk State University (NR TSU), Freydin V. I. ,   National Research Tomsk State University (NR TSU)
Published: December 2022

Bayesian networks are currently a popular tool for solving various problems, including creating decision support systems. This paper proposes a tool for creating a Bayesian network and direct probabilistic inference. The specificity of the problem consists in working with large networks (more than 1000 nodes) with a large number of parent nodes at one node (15 or more). The tool is integrated with Redmine and allows you to calculate the probability of a manager's error when determining the current state of the project.
Development and study of PMSM nonlinear controllers providing quick response and electromagnetic torque accurate control
Authors:   Sevastopol State University, Zavyalov V. M. , Bevz D. V. ,   «Mechatronica-Pro»
Published: December 2022

A permanent magnet synchronous motor electromagnetic torque control algorithms providing high dynamic performances based on the nonlinear automatic control theory were developed and studied. The new nonlinear control algorithm, called «differential control», that provides accurate torque control with a quick response, was developed. This algorithm is based on equality of controlled variable derivative sign and its error sign.
Formation of Coatings Based on Al2O3 on Polypropylene by the Electron-Beam Method in the Forevacuum Pressure Region
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Tran V. T. , Klimov A. S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Zenin A. A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

The article presents the results of using an electron beam for evaporation and deposition of ceramic coatings on polypropylene. Ceramics based on Al2O3 was used as the evaporated material. To generate an electron beam, a forevacuum plasma electron source was used, the need for which is due to its high efficiency in the processing of dielectrics. It has been shown that when creating coatings by this method on materials with low heat resistance, it is necessary to accurately control the time and rate of evaporation of ceramics. The optimal modes of coating deposition were determined, under which the temperature of the polymer does not rise above 80 °C. Photographs of applied coatings, their optical and surface properties are presented.
Metody obrazowania w radioterapii sterowanej obrazem
Authors: Graczyk Kinga , Kruszyna-Mochalska Marta
Published: December 2022

Radioterapia sterowana obrazem (ang. Image-Guided Radiation Therapy – IGRT) to technika wykorzystująca obrazowanie dwu- i trójwymiarowe. Stosowana jest, aby dokładnie zlokalizować objętość leczoną przed ekspozycją pacjenta na wiązkę terapeutyczną, generowaną w celu realizacji planów leczenia zapewniających wysoką precyzję dostarczania dawki, opartych na technikach z modulacją intensywności wiązki.  

Celem niniejszej pracy było omówienie używanych obecnie w radioterapii sterowanej obrazem metod obrazowania - wolumetrycznych i planarnych, opartych na wykorzystaniu promieniowania jonizującego i pozostałych, które opierają się na zjawiskach niejonizacyjnych.
Implications of elevation-dependent warming to water resources over the Chinese Qilian Mountains
Authors: Zhao Peng , He Zhibin , Du Jun
Published: December 2022

Warming in mountainous regions has experienced obvious elevation dependence (the warming rate of air temperature is amplified with elevation), which accelerates the melting of ice and snow, affecting glacier size and mass, and water resources in mountainous regions. Here, we used ERA5-Land monthly averaged datasets from 1979 to 2019 to analyze the elevation-dependent warming (EDW) variability, driving factor, and its implications to water resources in the Qilian Mountains (QLM). Results showed that: (1) Annual mean temperature shows a significant increasing trend in the QLM from 1979 to 2019 (0.31 °C/10a; p < 0.01), and the warming rate of annual mean temperature increased with elevation in the QLM in general. For seasonal scales, the most obvious EDW was found in summer. In the past 41 years, snow cover and snow depth showed a slight decreasing trend. There was a significant negative correlation between temperature and snow cover, which can explain that enhanced regional warming has caused decreases in snow cover and snow depth, largely controlling the pattern of EDW on the QLM. EDW has significant implications for water resources over QLM, especially above 5,000 m. Our study can provide a reference in understanding the importance of EDW to water resources in mountainous areas.
Wastewater monitoring of COVID-19: a perspective from Scotland
Authors: Fang Zhou , Roberts Adrian M. I. , Mayer Claus-Dieter , Frantsuzova Anastasia , Potts Jackie M. , Cameron Graeme J. , Singleton Peter T. R. , Currie Iona
Published: December 2022

Scotland introduced wastewater monitoring for COVID-19 early in the pandemic. From May 2020, samples have been taken and analysed using quantitative polymerase chain reaction (qPCR). The programme was expanded to over 100 sites accounting for around 80% of the population. Data are presented publicly via a dashboard and regular reports are produced for both the public and health professionals. Wastewater-based epidemiology (WBE) offers opportunities and challenges. It offers an objective means of measuring COVID-19 prevalence and can be more practical or timely than other methods of mass testing. However, it also has substantial variability impacted by multiple environmental factors. Methods for data collection and analysis have developed significantly through the pandemic, reflecting the evolving situation and policy direction. We discuss the Scottish experience of wastewater monitoring for COVID-19, with a focus on the analysis of data. This includes our approach to flow normalisation, our experience of variability in measurements and anomalous values, and the visualisation and presentation of data to stakeholders. Summarising the Scottish methodology as of March 2022, we also discuss how wastewater data were used for informing policy and public health actions. We draw lessons from our experience and consider future directions for WBE in Scotland.
WITHDRAWN: The Radix Achyranthes Bidentata Regulates BMSCsderived
Chondrogenic Differentiation by Modulating Rab39a and Activating
SOX9 and RHOA/RACK1 Signaling
Authors: Peng Liping , Zhou Ziqiong , Ma Dujun , Zhao Jing , Zhong Jing , Liao Zhouwei , She Ruihao
Published: December 2022

The article has been withdrawn at the request of the authors of the journal Letters in Drug Design & Discovery.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Effects of Exercise on Circulating Muscle-related Cytokines in Adults with
Type 2 Diabetes and/or Obesity
Authors: Hamasaki Hidetaka
Published: December 2022

Background:

Skeletal muscle is an endocrine organ that plays an important role in metabolic
health by secreting a variety of myokines. Recent studies have shown that exercise significantly
decreases interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in patients with type 2
diabetes (T2D). This paper explores the effect of chronic exercise on myokines in patients with
T2D and/or obesity.

Methods:

The author searched for relevant English-language articles in PubMed. A total of 14 randomized
controlled studies were found to be eligible for this short review.

Results:

It has been observed that chronic exercise does not change brain-derived neurotrophic factor
(BDNF), irisin, and secreted protein acidic and rich in cysteine levels, whereas it decreases
TNF-α levels in patients with T2D. Combined aerobic exercise (AE) and resistance training (RT)
or sprint interval training increase insulin-like growth factor 1 (IGF-1) levels and decrease IL-6 and
IL-15 levels in patients with T2D. Combined AE and RT may also increase IL-15 levels in obese
individuals. In addition, RT alone may increase BDNF, IGF-1, and IL-7 levels in overweight individuals.
However, AE alone does not change circulating myokine levels in patients with T2D,
while it may increase myonectin levels in obese individuals.

Conclusion:

This short review demonstrated that exercise appears to have favorable effects on
some myokines in patients with T2D and/or obesity. However, it remains inconclusive due to the
heterogeneity in subject characteristics and exercise modalities.
ROCK (RhoA/Rho Kinase) Activation in Atrial Fibrillation: Molecular
Pathways and Clinical Implications
Authors: Proietti Riccardo , Giordani Andrea S. , Lorenzo Calò A.
Published: December 2022

Abstracts:

Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and
oxidative stress play a major role, both triggered by inflammatory processes. The additional basic
event taking place in AF is atrial fibrotic remodeling, again triggered by oxidative stress, which is
determined by connexins rearrangement and differentiation of fibroblasts into active collagensecreting
myofibroblasts. RhoA/ROCK system is the final pathway of a wide spectrum of molecular
effectors such as Angiotensin II, platelet-derived growth factor, connective tissue growth factor
and transforming growth factor β, that overall determine calcium dysregulation and pro-fibrotic
remodeling. Both in experimental and clinical studies, RhoA/ROCK activation has been linked to
superoxide ion production, fibrotic remodeling and connexins rearrangement, with important consequences
for AF pathogenesis. ROCK pathway inhibition may therefore be a therapeutic or preventive
target for special AF subgroups of patients.
WITHDRAWN: Design of High-Speed Low Voltage Operational Amplifier
Authors: Jain Shruti
Published: December 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal " Current Diabetes Review ".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
As línguas vernaculares e a identidade cultural em Literatura Moçambicana de Língua Portuguesa: o encontro de vozes entre Paulina Chiziane e Mia Couto
Authors: Abubakar Innocent
Published: December 2022

Some Mozambican novels, written in Portuguese, bring with them a vocabulary of Mozambican vernacular languages, developed in the novel and translated in a final wordlist. The wordlist highlights the background that these Mozambican languages lend to Portuguese in communication, despite their “marginalization” in this country where official communication is reserved for standard Portuguese language, and it is part of what makes Mozambican this literature of Portuguese language. Despite its rich linguistic and literary content, the study of the wordlist, as part of the novel, has not yet attracted the attention of Mozambique’s literary and linguistic critics. It is necessary to understand the lexical field used and the communication situations in which these languages are used in that literature, if there are some Mozambican sociocultural realities that the Portuguese language does not effectively transmit, making the use of vernacular languages impera-tive. This work is based on these questions and its corpus is the wordlist of the novels Ventos do apocalipse by Paulina Chiziane and O outro pé da sereia by Mia Couto. It is bibliographical research as conceived by Fonseca (2002) whose analysis uses some theories, such as Charaudeau (2002) on the relationship between cultural identity, language and discourse.