bluuebunny/crossref_metadata_2025 huggingface dataset:
Constructions of complete sets
Authors: Papini Pier Luigi , Wu Senlin
Published: October 2015

Constructing constant width sets or, more generally, complete sets in Banach spaces seems to be a not so easy task. A new construction working in separable Banach spaces is presented, and Bavaud’s and Lachand-Robert and Oudet’s constructions of complete sets are extended to a more general context.
On the geometrical properties of solvable Lie groups
Authors: Aghasi Mansour , Nasehi Mehri
Published: October 2015

In [3] Bozek introduced a class of solvable Lie groups M2n+1. Calvaruso, Kowalski and Marinosci in [9] have studied homogeneous geodesics on these homogeneous spaces with an arbitrary odd dimension. In [1] we have studied some other geometrical properties on these spaces with dimension five. Our aim in this paper is to extend those geometrical properties for an arbitrary odd dimension in both Riemannian and Lorentzian cases. In fact we first obtain all of the descriptions of their homogeneous Lorentzian and Riemannian structures and their types. Then we calculate the energy of an arbitrary left-invariant vector field X on these spaces and in the Lorentzian case we prove that no left-invariant unit time-like vector fields on these spaces are critical points for the space-like energy. There is also a proof of non-existence of invariant contact structures and left-invariant Ricci solitons on these homogeneous spaces.
The Log-Convex Density Conjecture and vertical surface area in warped products
Authors: Howe Sean
Published: October 2015

We examine the vertical component of surface area in the warped product of a Euclidean interval and a fiber manifold with product density.We determine general conditions under which vertical fibers minimize vertical surface area among regions bounding the same volume and use these results to conclude that in many such spaces vertical fibers are isoperimetric. Our main hypothesis is that the surface area of a fiber be a convex function of the volume it bounds. We apply our results in the specific case of ℝn − {0} realized as the warped product (0, ∞) ×r Sn−1, providing many new examples of densities where spheres about the origin are isoperimetric, including simple densities with finite volume, simple densities that at the origin are neither log-convex nor smooth, and non-simple densities. We also generalize the results of Kolesnikov and Zhdanov on large balls in Rn with increasing strictly log-convex simple density. We situate our work in relation to the Log-Convex Density Conjecture of Rosales et al. and the recent work by Morgan, Ritoré, and others on formulating a generalized log-convex density/stable spheres conjecture.
Locally Monge–Ampère parabolic foliations
Authors: Kalka Morris , Patrizio Giorgio
Published: October 2015

It is shown that codimension one parabolic foliations of complex manifolds are holomorphic. This is proved using the facts that codimension one foliations of complex manifolds are necessarily locally Monge- Ampère foliations and that parabolic leaves cannot have hyperbolic behavior. The result holds true also for locally Monge-Ampère foliations with parabolic leaves of arbitrary codimension.
Real open books and real contact structures
Authors: Öztürk Ferit , Salepci Nermin
Published: October 2015

A real 3-manifold is a smooth 3-manifold together with an orientation preserving smooth involution, called a real structure. In this article we study open book decompositions on smooth real 3-manifolds that are compatible with the real structure.We call them real open book decompositions.We show that each real open book carries a real contact structure and two real contact structures supported by the same real open book decomposition are equivariantly isotopic. We also show that every real contact structure on a closed 3-dimensional real manifold is supported by a real open book. Finally, we conjecture that two real open books on a real contact manifold supporting the same real contact structure are related by positive real stabilizations and equivariant isotopy, and that the Giroux correspondence applies to real manifolds as well, namely that there is a one-to-one correspondence between the real contact structures on a real 3-manifold up to equivariant contact isotopy and the real open books up to positive real stabilization. Meanwhile, we study some examples of real open books and real Heegaard decompositions in lens spaces.
Magnetorelaxometry procedures for quantitative imaging and characterization of magnetic nanoparticles in biomedical applications
Authors: Liebl Maik , Wiekhorst Frank , Eberbeck Dietmar , Radon Patricia , Gutkelch Dirk , Baumgarten Daniel , Steinhoff Uwe , Trahms Lutz
Published: October 2015

Quantitative knowledge about the spatial distribution and local environment of magnetic nanoparticles (MNPs) inside an organism is essential for guidance and improvement of biomedical applications such as magnetic hyperthermia and magnetic drug targeting. Magnetorelaxometry (MRX) provides such quantitative information by detecting the magnetic response of MNPs following a fast change in the applied magnetic field.

In this article, we review our MRX based procedures that enable both the characterization and the quantitative imaging of MNPs in a biomedical environment.

MRX characterization supported the selection of an MNP system with colloidal stability and suitable cellular MNP uptake. Spatially resolved MRX, a procedure employing multi-channel MRX measurements allowed for

These MRX based measurement and analysis procedures have substantially supported the development of MNP based biomedical applications.
Validation of CFTR intronic variants identified during cystic fibrosis population screening by a minigene splicing assay
Authors: Giorgi Gianpietro , Casarin Alberto , Trevisson Eva , Donà Marta , Cassina Matteo , Graziano Claudio , Picci Luigi , Clementi Maurizio , Salviati Leonardo
Published: October 2015

Cystic fibrosis, caused by mutations of the

We have examined five

Four out of five variants (including c.2620-26A>G which was previously reported as a possible splice-site mutation) did not alter the correct splicing of the minigene and are likely to be neutral polymorphisms, whereas c.744-6T>G caused complete skipping of

Hybrid minigenes assay are a simple and rapid tool to evaluate the effects of intronic variants without the need of analyzing patient’s mRNA, and are particularly suited to analyze variants identified during population screenings.
Additive Archaeology: An Alternative
Framework for Recontextualising
Archaeological Entities
Authors: Reilly Paul
Published: October 2015

Additive manufacturing poses a number of challenges to conventional understandings of
materiality, including the so-called archaeological record. In particular, concepts such as real, virtual,
and authentic are becoming increasingly unstable, as archaeological artefacts and assemblages can be
digitalised, reiterated, extended and distributed through time and space as 3D printable entities. This paper
argues that additive manufacturing represents a ‘grand disciplinary challenge’ to archaeological practice
by offering a radical new generative framework within which to recontextualise and reconsider the nature
of archaeological entities specifically within the domain of digital archaeology.
Non-coding genome functions in diabetes
Authors: Cebola Inês , Pasquali Lorenzo
Published: October 2015

Most of the genetic variation associated with diabetes, through genome-wide association studies, does not reside in protein-coding regions, making the identification of functional variants and their eventual translation to the clinic challenging. In recent years, high-throughput sequencing-based methods have enabled genome-scale high-resolution epigenomic profiling in a variety of human tissues, allowing the exploration of the human genome outside of the well-studied coding regions. These experiments unmasked tens of thousands of regulatory elements across several cell types, including diabetes-relevant tissues, providing new insights into their mechanisms of gene regulation. Regulatory landscapes are highly dynamic and cell-type specific and, being sensitive to DNA sequence variation, can vary with individual genomes. The scientific community is now in place to exploit the regulatory maps of tissues central to diabetes etiology, such as pancreatic progenitors and adult islets. This giant leap forward in the understanding of pancreatic gene regulation is revolutionizing our capacity to discriminate between functional and non-functional non-coding variants, opening opportunities to uncover regulatory links between sequence variation and diabetes susceptibility. In this review, we focus on the non-coding regulatory landscape of the pancreatic endocrine cells and provide an overview of the recent developments in this field.
Dental anxiety and fear among a young population with hearing impairment
Authors: Suhani Raluca Diana , Suhani Mihai Flaviu , Badea Mindra Eugenia
Published: October 2015

Background and aim. Dental fear and anxiety is a major barrier for dental care provision. Identifying anxious patients can help dental professionals manage them appropriately. The study aimed at assessing dental fear and anxiety among a deaf population in Cluj-Napoca, Romania and their associated and contributing factors.Method. In this cross sectional study 165 deaf participants were invited to complete a questionnaire comprising three sections. The first section contained questions about social and economical status, the second comprised a Romanian version of the Modified Dental Anxiety Scale (MDAS) while part three was the Dental Fear Survey (DFS). Data was introduced and analyzed with the Statistical Package for Social Sciences (SPSS) program, version 20.0 (SPSS Inc., Chicago, Illinois, USA).Results. Thirty four point nine percent (34.9%) of respondents were found to be insignificantly anxious, 59.7% were moderately or extremely anxious with 5.3% being identified with dental phobia based on the MDAS scores. Mean total score for dental anxiety on the MDAS scale was 13.7. Patients suffering from a prior negative experience were found to be more anxious (p<0.05).Conclusions. Dental fear and anxiety is widespread in the deaf communities. Higher percentages were observed among women and people with a previous traumatic dental experience.
Matrix Gla protein in tumoral pathology
Authors: Gheorghe Simona Roxana , Crăciun Alexandra Mărioara
Published: October 2015

Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology.Until recently, it was thought to only have an inhibitory role of physiological and ectopic calcification. New studies demonstrated that it also has a role in physiological and pathological angiogenesis, as well as in tumorigenesis.The aim of this review is to report the latest findings related to the expression and clinical implications of matrix Gla protein in different types of cancer with an emphasis on cerebral tumors.
HAIR LOSS AND REGENERATION PERFORMED ON ANIMAL MODELS
Authors: Orasan Meda Sandra , Roman Iulia Ioana , Coneac Andrei , Muresan Adriana , Orasan Remus Ioan
Published: October 2015

Research in the field of reversal hair loss remains a challenging subject.As Minoxidil 2% or 5% and Finasteride are so far the only FDA approved topical treatments for inducing hair regrowth, research is necessary in order to improve therapeutical approach in alopecia. In vitro studies have focused on cultures of a cell type - dermal papilla or organ culture of isolated cell follicles . In vivo research on this topic was performed on mice, rats, hamsters, rabbits, sheep and monkeys, taking into consideration the advantages and disadvantages of each animal model and the depilation options. Further studies are required not only to compare the efficiency of different therapies but more importantly to establish their long term safety.
Deferred Consent for Randomized Controlled Trials in Emergency Care Settings
Authors: Harron Katie , Woolfall Kerry , Dwan Kerry , Gamble Carrol , Mok Quen , Ramnarayan Padmanabhan , Gilbert Ruth
Published: October 2015

BACKGROUND:

There is limited experience in using deferred consent for studies involving children, which was legalized in the United Kingdom in 2008. We aimed to inform future studies by evaluating consent rates and reasons for nonconsent in a large randomized controlled trial in pediatric intensive care.

METHODS:

In the CATCH trial, eligible children from 14 PICUs in England and Wales were randomly assigned to 3 types of central venous catheters. To avoid delay in treatment, children admitted on an emergency basis were first randomly assigned to a trial central venous catheter, and we deferred seeking consent to use already collected data and blood samples until after stabilization.

RESULTS:

Consent was obtained for 984/1358 (72%) of children admitted on an emergency basis. Failure to obtain consent resulted mainly from a lack of opportunity (early discharge or transfer) for survivors and difficulties in seeking consent for children who died. For admissions where there was an opportunity to approach (n = 1298), inclusion rates differed according to survival status: 93/984 (9%) of consented patients died, compared with 58/314 (18%) of nonconsented patients. For children admitted on an emergency basis whose families were approached, 984/1178 (84%) provided deferred consent (n = 15 sites), compared with 441/641 (69%) of children admitted on an elective basis who were approached for prospective consent (n = 9 sites).

CONCLUSIONS:

Design of emergency randomized controlled trials should balance the potential burden that seeking consent in difficult situations may cause against risk of bias by disproportionately excluding children who die or are transferred. Ethics committees could consider approving the use of already collected data when best efforts to obtain deferred consent are unsuccessful.
Antenatal Three-Dimensional Printing of Aberrant Facial Anatomy
Authors: VanKoevering Kyle K. , Morrison Robert J. , Prabhu Sanjay P. , Torres Maria F. Ladino , Mychaliska George B. , Treadwell Marjorie C. , Hollister Scott J. , Green Glenn E.
Published: October 2015

Congenital airway obstruction poses a life-threatening challenge to the newborn. We present the first case of three-dimensional (3D) modeling and 3D printing of complex fetal maxillofacial anatomy after prenatal ultrasound indicated potential upper airway obstruction from a midline mass of the maxilla. Using fetal MRI and patient-specific computer-aided modeling, the craniofacial anatomy of the fetus was manufactured using a 3D printer. This model demonstrated the mass to be isolated to the upper lip and maxilla, suggesting the oral airway to be patent. The decision was made to deliver the infant without a planned ex utero intrapartum treatment procedure. The neonate was born with a protuberant cleft lip and palate deformity, without airway obstruction, as predicted by the patient-specific model. The delivery was uneventful, and the child was discharged without need for airway intervention. This case demonstrates that 3D modeling may improve prenatal evaluation of complex patient-specific fetal anatomy and facilitate the multidisciplinary approach to perinatal management of complex airway anomalies.
CREATIVITY AND INDEPENDENCE
Authors: Crowdy Denis
Published: October 2015

Crowdy addresses a distinctly local activity, the production of a syncretic style of pan-Papua New Guinean music, entitled 'PNG Contemporary' by its practitioners, which has been nurtured since the late 1970s by the PNG Higher Education system.
DOCTORED JAZZ
Authors: Johnson Bruce
Published: October 2015

Johnson's historical study dissects the role that specialist jazz journals had in constructing agendas of taste and legitimation for particular styles of jazz music in Australia.
FROM A DISTANCE
Authors: Garde Murray
Published: October 2015

Murray Garde's article combines a study of the Aboriginal musical culture of the Maningrida area, in Arnhem Land (Northern Territory, Australia), with an analysis of the international responses to their world wide web site and a discussion of the manner in which (some) Internet communities can also use the medium in ways which serve to perpetuate- rather than dissipate -essentialism and myth making with regard to indigenous cultures.
SOUTH·SEA·ISLAND MAGIC
Authors: Sampson Sam
Published: October 2015

This article provides a detailed study of the career of leading New Zealand-based steel guitarist Bill Sevesi (and his contemporaries Trevor Edmondson and Bill Wolfgramm).
AFTER THE LAW
Authors: Homan Shane
Published: October 2015

Shane Homan's detailed case study of the political witch-hunt conducted against the operators of Sydney's Phoenician Club, after the ecstasy-related death of a juvenile who had attended a dance party at the club earlier on the same night, illustrates how legislation concerning the regulation of public spaces can be deployed in a punitive manner in response to particular 'moral panics' and/or political opportunism. Drawing broader implications, Homan also points to the manner in which such complex regulatory webs have succeeded in severely restricting the range of venues available for live music performance in Sydney, drastically altering the city's music culture over the last decade.
MISPLACED ACAPELLA
Authors: Joyce Coralie
Published: October 2015

Joyce provides a critique and reinterpretation of arguments presented by Rickwood ( 1998) in her discussion of Australian acapella music.
THE PEDAGOGY, CULTURE AND APPROPRIATION OF JAZZ IN PAPUA NEW GUINEA
Authors: Crowdy Denis , Goddard Michael
Published: October 2015

Utilising first hand experience the authors trace the attempted development of 'serious' jazz in PNG. Incorporating scholarly, promotional and 'musicianly' perspectives, they highlight the tension present in the PNG jazz scene
GUMLEAF PLAYING COMPETITIONS
Authors: Ryan Robin
Published: October 2015

The author considers a tension present in the different performance styles of Aboriginal and non-Aboriginal contestants in gumleaf playing competitions. Drawing from extensive research throughout the decade, she 'animates' the scene through detailed explanations of gum leaf playing styles and the history that has· brought them to existence. (gum/leafplaying remains an identifiably Australian activity. A leafist places his/her instrument against the lips and blows air across it; the precise method and the quality of mid to high-pitched sounds produced varies markedly depending on the leafist's expertise and the species of eucalyptus selected.)
PNG CONTEMPORARY AND THE COMMERCIAL SPHERE
Authors: Philpott Malcom , Seeto Greg
Published: October 2015

The' Riffs' section continues Perfect Beat's commitment to on-going debates in the area of Pacific music and culture. Philpott and Seeto respond to ideas raised by Crowdy ( 1998), specifically around the PNG Contemporary style and the role of Pacific Gold Studios. Crowdy (this issue) then replies to the concerns raised by Philpott (and Greg Seeto), (re)addressing his original analyses
PNG CONTEMPORARY AND THE ROLE OF THE FCA DENIS CROWDY
Authors: Crowdy Denis
Published: October 2015

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MODERN APPROACH TOWARDS SURGICAL TREATMENT OF CORONARY HEART DISEASE IN DIABETIC PATIENTS
Authors: Bokeria L. A. , Golukhova E. Z. , Sigaev I. Yu. , Keren М. A.
Published: October 2015

In the recent years there has been registered an increase in diabetes mellitus (DM) morbidity, especially among able-bodied citizens. The steady increase in amount of DM patients inevitably leads to the increase in the amount of diabetic CHD patients – candidates for the surgical myocardial revascularization. This article contains analysis of choice of myocardial revascularization technique in patients with CHD and concomitant DM. It also contains data from the study of endovascular and surgical treatment of CHD results in diabetic patients. This study also included postoperative complications analysis with exposure of complication development predictors and was held in Bakulev Scientific Centre of cardiovascular surgery. Results obtained in the study testify to the fact that DB increases relative risk of cardio-vascular complications (cardiac death, myocardial infarction and restenosis of special-purposed stenosis) development in patients with CHD after percutaneous coronary intervention with stenting. DM is an independent risk factor that increases myocardial infarction development risk, recurrence of stenocardia and shunt failure during the three year follow up after the coronary artery bypass grafting done in CHD patients.
IMPROVING EFFICACY OF FLUORESCENT DIAGNOSTICS OF SKIN AND MUCOSAL TUMORS IN OCULAR ONCOLOGY
Authors: Novikov I. A. , Grusha Ya. O. , Kirushchenkova N. P.
Published: October 2015

Developed in 2006 by our institute, the method of primary detection of skin and mucosal tumors based on non-induced fluorescence of endogenous protoporphyrin IX is used to estimate proliferative activity of tumor and its probable progression. This study was aimed to improve method efficacy by means of additional parameter which would quantitatively describe the interpenetration of tumor and surrounding tissues. The authors analyzed autofluorescent data of 97 patients and determined medico-biological factors which could cause controversal results (all cases were histologically controlled). The coefficient of interpenetration Kdith was proposed as a solution. It is calculated as averaged reciprocal to tumor border probability. Repeated analysis of the autofluorescent images using both the proliferative factor and coefficient of interposition revealed improvement of method specificity from 69% to 85% while sensitivity of method remained 70%. In authors’ opinion, the method can be recommended for use in general oncology and dermatology.
THE STATE OF ART, PROBLEMS AND FUTURE OF TRANSFUSIOLOGY
Authors: Ragimov A. A.
Published: October 2015

The article specifies the main areas of modern transfusiology: blood services, transfusion immunology, clinical and industrial transfusiology. Our research work and the analysis of published data made it possible to specify a new paradigm of transfusion medicine — the transition from the doctrine of blood components transfusion to molecular transfusiology, which comprises medicamentary transfusiology based on the use of gene engineering and biotechnology components as well as blood components preparations, high-tech methods of extracorporeal molecular hemocorrection and highly specific laboratory technology. In view of this concept we develop and introduce modern methods of transfusion medicine and laboratory technologies, aimed at providing the safety of transfusion manipulations and optimizing their use in clinical practice. Transfusion immunology is a part of Transfusion Medicine, studying and implementing in practice the immunological safety and efficacy of transfusions. The article also specifies the main criteria for blood donation and blood components transfusion in patients with hereditary abnormalities of blood; a new approach to evaluation of blood donors potential in endemic foci of inherited abnormalities of blood. The results of the research work formed the basis for protocols of donors examination and the treatment of patients needing hemo transfusion, optimized the tactics of decreed research during the examination of blood donors and patients needing blood transfusion.
INTRACELLULAR TARGETS OF PROAPOPTOTIC INFLUENCE OF GASEOUS TRANSMITTERS
Authors: Tashireva L. A. , Starikova E. G. , Novitskii V. V. , Ryazantseva N. V.
Published: October 2015

Main molecular targets of nitric oxide, hydrogen sulfide and carbon monoxide proapoptotic action in Jurkat cells were determined in this study. Decrease of mitochondrial transmembrane potential was shown during all three gases action. Reason of this event is the Bcl-2 family members disbalance. Proapoptotic proteins release after mitochondrion membranes permeabilisation could be abolished by protein xIAP inhibition of caspase -9 and-3 activity during NO and CO application.
CHEMOTHERAPY OF TUBERCULOSIS: PROBLEMS AND PERSPECTIVES
Authors: Vasil’eva I. A. , Samoilova A. G. , Ergeshov A. E. , Bagdasaryan T. R. , Chernousova L. N.
Published: October 2015

Challenges of tuberculosis chemotherapy under conditions of high drug resistant (DR) tuberculosis burden are discussed. Ultimate results of treatment by standard regimens of 1658 patients with new tuberculosis cases and relapses were analyzed. Favorable ultimate results were observed among both patients with new tuberculosis cases and relapses having drugs sensitivity. Efficacy of tuberculosis treatment by standard regimens of chemotherapy is decreasing as a result of DR amplification. Risk factors of unfavorable ultimate result among pulmonary tuberculosis patients are primary resistance to isoniazid (OR =2,1) and multiple drug resistance of M. tuberculosis (OR =8,0). Earlier onset of treatment and correct individual therapy with second line drugs as a result of rapid methods of DR tuberculosis diagnostics are those approaches which provide the best therapeutic effect among multiple drug resistant tuberculosis patients both in culture conversion (97,7%) and cavity closure rate (82,7%).
FEATURES ОF METABOLIC ACTIVITY ОF VASCULAR ENDOTHELIUM IN PATIENTS WITH PULMONARY TUBERCULOSIS
Authors: Kaminskaya G. O. , Abdaullaev R. Yu. , Komissarova O. G.
Published: October 2015

81 patients with active pulmonary tuberculosis were investigated. The morpho-functional status of vascular endothelium was evaluated by plasma levels of stable metabolites of nitric oxide, endothelin-1 and von Willebrand factor antigen. Typical increase of endothelin-1 in positive correlation with systemic inflammatory response syndrome (SIRS) expression was established. Nitric oxide level decreased in patients with chronic and severe course of disease. Decrease of nitric oxide level was not associated with SIRS but was consequence of specific intoxication. von Willebrand factor antigen decreased in patients with recent and limited spread of tissue damage but increased progressively with intensity of SIRS. This complex of changes (contrast shifts of nitric oxide and endothelin-1 and von Willebrand factor antigen increase) manifested in endothelium metabolic dysfunction syndrome and developed pre-conditions for microcirculation disturbances.
PREVENTION OF TUBERCULOSIS: CURRENT APPROACHES TO DEVELOPMENT OF VACCINES
Authors: Stukova M. A. , Zabolotnykh N. V. , Vinogradova T. I. , Gergert V. Ya. , Apt A. S. , Erokhin V. V. , Kaprelyants A. S. , Yablonskii P. K. , Kiselev O. I.
Published: October 2015

This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous «prime-boost» vaccination strategy against tuberculosis is discussed.
THE ROLE OF INTERLEUKIN-1 AND ASSOCIATED CYTOKINES IN GASTRIC CARCINOGENESIS
Authors: Matveeva L. V. , Mosina L. M.
Published: October 2015

This review presents detailed analysis of scientific data on influence of the associated with interleukin-1 cytokines on the development of malignant tumors of stomach with the definition of spectrum of diagnostic and therapeutic possibilities. Cytokines associated with interleukin-1 directly and indirectly involved into gastric carcinogenesis. Implementation of pro- and contreoncogenic effects depends on many factors. The serological and genetic criteria changes of interleukin-1 have high diagnostic value and prognostic significance opening new differential approaches to the treatment of precancer conditions and gastric cancer.
CLINICAL AND EXPERIMENTAL RESEARCH OF IMMUNOMODULATORY EFFECT OF AMISULPRIDE
Authors: Vetlugina T. P. , Lobacheva O. A. , Al'perina E. L. , Zhukova E. N. , Semke A. V. , Nikitina V. B. , Cheido M. A. , Idova G. V.
Published: October 2015

Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (В lymphocytes, immunoglobulins, HLA-DR+-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.
CARDIONEUROLOGY: THE UP-TO-DATE KEY POSITIONS AND THE FUTURE PROSPECTS
Authors: Suslina Z. A. , Fonyakin A. V. , Geraskina L. A.
Published: October 2015

The up-to-date key positions and the future prospects of cardioneurology were analyzed. The wide range of questions of cardioneurology was represented and the necessity of the interdisciplinary approach to the diagnostics, treating and prevention of the cerebrovascular diseases were proved. It was pointed that the studied problems are the priority directions in angioneurology and have great social and clinical importance.
THE ASSESSMENT OF REACTIONS OF POLYGRAPHIC PARAMETERS AT HRV-BIOFEEDBACK TRAINING IN ADOLESCENTS WITH DIFFERENT VARIANTS OF CARDIAC AUTONOMIC NERVOUS SYSTEM TONE
Authors: Demin D. B.
Published: October 2015

There is examine a character of change of brain bioelectric activity and polygraphic indicators at sessions of biofeedback by heart rhythm variability parameters (HRV-biofeedback) in 15–17 years adolescents who have different variants of cardiac autonomic nervous system tone. It is taped, that adolescents with cardiac balanced tone have more intensive optimization of functional brain activity in comparison with adolescents who have cardiac sympathetic tone — increase on alpha-activity and theta-activity depression in electroencephalogram structure. There were optimization of neurodynamic processes and most expressed stabilization of the hemodynamics indicators in adolescents with cardiac sympathetic tone after HRVbiofeedback training.
ONCOLYTIC PARVOVIRUSES. A NEW APPROACHES FOR CANCER THERAPY
Authors: Loktev V. B. , Ivan'kina T. Yu. , Netesov S. V. , Chumakov P. M.
Published: October 2015

Parvoviruses such as parvovirus H-1 (H-1PV) may selectively infect and lysis cancer cells. The parvoviruses also induce an immune system to eliminate the tumor cells through the formation of anti-cancer immunity. One of the possible mechanisms of antitumor activity is associated with the direct induction of apoptosis by parvoviral proteins NS1 and 11 kDa. Parvovirus-based vectors are promising for gene therapy of oncological diseases and genetic disorders in humans. Parvoviruses were successfully used for the experimental treatment on animal models of human glioma, neuroblastomas, lymphomas, pancreatic carcinoma, carcinomas and breast tumors. ParvOryx is the first oncolytic preparation constructed on the base of H-1PV; its phase I/IIa clinical trials in patients with glioblastoma multiforme are in process.
CLINICAL SIGNIFICANCE OF INSULIN RESISTANCE SYNDROME IN DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PRIMARY GOUT
Authors: Kushnarenko N. N. , Govorin A. V. , Shcherbakova O. A. , Sotnikova S. G. , Ivanitskaya O. V.
Published: October 2015

Endothelial function has been studied in 175 males with primary gout. It has been established that incidence of endothelial dysfunction in patients with primary gout was associated with the clinical course and was marked most of all in patients who had a chronic gout. The correlations found between the parameters of endothelial dysfunction and impaired carbohydrate metabolism suggest close link and coordination between the above processes which contribute greatly to development and progress of atherosclerosis in such patients.
PROTEOMIC PROFILE AND NON-SPECIFIC IMMUNOPROPHYLAXIS OF RESPIRATORY DISEASES IN FREQUENTLY SICK CHILDREN
Authors: Sarvilina I. V. , Romantsov M. G.
Published: October 2015

We have investigated efficacy of meglumine acridonacetate (Cycloferon) in frequently sick children (FSC) on the basis of serum proteomic profile dynamics; we have also studied epidemiologic efficacy of interferon inductor as a mean of non-specific immunoprophylaxis. FSC were subjects to follow up during 4–10 years. We have used recommended regimens of drug administration. Were analyzed: anamneses of FSC, clinical symptoms, infectious index calculation, stratification of children into 5 groups of FSC and separation of children with truly frequent recurrent respiratory viral diseases. On the basis of proteomic blood analyzes the following parameters of efficacy of treatment with meglumine acridonacetate were defined: expression intensity of Rho- and Ras-signaling pathways proteins. Epidemiologic efficacy of the drug was 2,9 (from 2,4 to 3,4), rate of protection — 62,8% (58,5–67,1%).
SCIENTIFIC APPROACH TO ESTABLISHING SYSTEM OF PROVIDING FIRST AID CARE IN THE RUSSIAN FEDERATION
Authors: Lysenko K. I. , Dezhurnyi L. I. , Neudakhin G. V.
Published: October 2015

The article is devoted to evaluation of situation with providing fist aid in the Russian Federation. It discusses the necessity to establish first aid system in the Russian Federation and formulates its principles. The need in establishing such system is caused by necessity to draw a wide range of persons, including those who are not medically educated, to provide first aid service to patients. Also substantiated the need of development and adoption of the legislation that adjusts different aspects of first aid, as well as alteration in a current legislation. Proved the necessity of establishment and functioning of the intersectional coordination council. Consideration is given to principles of functioning of the training system for first aid providers. Principles, which will help to provide them with first aid tools, are substantiated.
NANOSTRUCTURED LIPOSOMAL SYSTEMS AS TRANSPORT AGENTS FOR ANTICANCER DRUGS
Authors: Baryshnikov A. Yu.
Published: October 2015

Liposomes quite recently have turned from a model of biological membranes into an object of extensive research and practical use. The versatile traits of liposomal formulation allow its' universal implementation, especially in cancer chemotherapy. The advantages of liposomal use as a carrier of an anticancer drug for its targeted selective accumulation are discussed in this article. This article contains description of new types of liposomes, differing in contents and use, such as: simple, sterically stabilized, targeted (immunoliposomes),cationic, sensitive to physical and chemical stimuli. The characteristics of liposomal systems of anticancer drug delivery designed at Blokhin Russian Oncological Scientific Centre is given in the article.
THE ROLE OF REGULATORY T CELLS IN THE DEVELOPMENT OF AUTOIMMUNE PROCESS IN MULTIPLE SCLEROSIS
Authors: Eliseeva D. D. , Zavalishin I. A. , Karaulov A. V. , Bykovskaya S. N.
Published: October 2015

In the maintenance of immunological tolerance important role belongs to the recently discovered population of regulatory T-cells CD4 + CD25 + FoxP3 +. These cells have potential in suppressing pathologic immune responses observed at various autoimmune diseases including multiple sclerosis. We have shown a reduction in the number and functional activity of T-reg in peripheral blood of patients with multiple sclerosis in the acute stage, the increase in their number during remission, duration of the relationship of the autoimmune process and the degree of disability of patients with the contents of T-reg. The possibility of using the grown ex vivo T-reg for the correction of immunopathological process in multiple sclerosis.
ROLE OF ENDOTHELIUM IN REMODELLING A MYOCARDIUM LEFT VENTRICULAR AT PATIENTS ON A HEMODIALYSIS
Authors: Kharlamova U. V. , Il'icheva O. E.
Published: October 2015

To study influence of markers of function endothelium on structurally functional indicators left ventricular at patients on a hemodialysis.. 98 patients on a hemodialysis are surveyed. To all patients defined concentration stable metabolites of oxyde nitrogen whey of blood, total cholesterol, cholesterol of low density lipoproteine, cholesterol of high density lipoproteine, triglycerides, homocysteine, Willebrand factor, spent echocardiography research. During correlation, multiple regression the analysis independent influence of indicators of function endothelium on structurally functional indicators of a myocardium left ventricular, processes of formation of dysfunction of heart reflecting parallelism and endothelium is revealed
THE REGISTERS OF ACUTE CORONARY SYNDROMES – THEIR TYPES, CHARACTERISTICS AND SIGNIFICANCE IN CLINICAL PRACTICE
Authors: Erlikh A. D.
Published: October 2015

The term registry in individual application to patients with acute coronary syndrome (ACS) is discussed in this review. The author performs a detailed analysis of literature concerning objectives and goals of registries and their significance in clinical practice. The marked differences can be found between registries and randomized clinical trials (RCT). After the example of ACS registries the author shows the influence of information received according to registries limits on the formation of recommendations on treatment of patients with ACS.
AGONIST OF V2 VASOPRESSIN RECEPTOR REDUCES DEPRESSIVE DISORDERS IN POST-STROKE PATIENTS
Authors: Belokoskova S. G. , Stepanov I. I. , Tsikunov S. G.
Published: October 2015

Poststroke depression is one of the common psychiatric complications after stroke. Thus, the research of new ways for treatment depressed mood after stroke is actual. The previous researches revealed vasopressin to be effective in patients with memory, speech and motor function disorders after stroke. The purpose of the study was to investigate influence of vasopressin on depression after stroke. Fourteen patients with affective disorders have been treated with subendocrine doses of 1-desamino-8-D-arginin-vasopressin (DDAVP) daily by intranasal application during 1,5–2 months. Vasopressin was effective in correcting both apatoadinamic and anxious depression. Treatment effect was durable, lasts for 0,5–1 year after the first course of therapy. The results of this pilot study demonstrate perspective of using selective agonist of vasopressin V2 receptors, DDAVP, in therapy of post-stroke depression.
THE CLASSIFICATION OF FUNCTIONAL DISORDERS OF BRAIN ACTIVITY IN PATIENTS WITH BRAIN TUMORS
Authors: Voronina I. A. , Voronov V. G.
Published: October 2015

This paper is devoted to the automatic classification of functional disorders of brain activity in patients with brain tumors on the basis of the reference groups. The test of statistical hypotheses set made crisp classification. Functional activity of the brain abnormality is assessed indicators of the frequency spectrum of the EEG. We describe the scheme of the algorithm and an analysis of the results. The publication is intended for IT-professionals and clinicians who are actively applying them in their work.
PHYLOGENESIS, ETIOLOGY AND PATHOGENESIS OF INSULIN RESISTANCE. DIFFERENCES FROM TYPE II DIABETES MELLITUS
Authors: Titov V. N.
Published: October 2015

We believe that etiological factor of insulin resistance is phylogenetically late formation of insulin and its specific functionality, i.e., providing energy substrates for the biological function of locomotion. According to biological subordination, insulin cannot change regulation formed at the early stages of phylogenesis in all cells, including those that become insulin-dependent at the late stages of phylogenesis. This involves a) β-oxidation of fatty acids in the mitochondria, b) synthesis of С 16:0 palmitic saturated fatty acid, c) glucose metabolism in pro- and eukaryotes, d) regulation of biochemical reactions in insulin-independent cells, e) humoral effects of mediators at the level of paracrine cell communities which are structural and functional units of all internal organs, and f) hormonal regulation at the entire organism level. Pathogenetic factors of insulin resistance are biochemical and functional disorders occurring in vivo upon activation of biological functions and reactions that formed phylogenetically earlier than insulin. During phylogenesis the insulin system has intrinsically built up over the regulatory mechanisms of mitochondria, early unicellular organisms and paracrine cell communities. Insulin functionally interacts with them all, but it cannot abolish the effects of any phylogenetically earlier humoral mediator. Insulin resistance is a pathophysiological disparity between humoral regulation of metabolism at the level of phylogenetically earlier paracrine cell communities and at the level of phylogenetically late total organism, on the one hand, and successive phylogenetic formation of passive cellular uptake of fatty acids as unesterified fatty acids and later triglycerides, on the other. If insulin resistance results from changes in the primary structure of transport proteins, in glucose storage and cellular insulin reception, it can be referred to as type II diabetes mellitus.
TREATMENT OF HIV-INFECTION BY MEANS OF GENE THERAPY
Authors: Glazkova D. V. , Bogoslovskaya E. V. , Markelov M. L. , Shipulin G. A. , Pokrovskii V. V.
Published: October 2015

Current methods of HIV treatment can contain a progression of the disease; however they do not lead to a cure. Lifelong antiretroviral therapy is therefore necessary, leading to problems of cost and toxicity of chemical drugs. The recent advances in science have allowed a new approach to the HIV-treatment — gene therapy. In the present publication we focus on one strategy of the gene therapy called «intracellular immunization». The strategy is based on the introducing of antiviral genes into the HIV-sensitive cells. We highlight the mechanisms of action of various antiviral genetic agents and discuss some issues concerning target cells and genes delivery. Finally we summarize the results of certain gene therapy clinical trials.
ABOUT EXPERIENCE OF PRODUCING CITY HEALTH PROFILE AS A PART OF THE INTERNATIONAL WHO HEALTHY CITIES PROJECT
Authors: Zhilenko E. L. , Gomerova N. I. , Zakharova M. A. , L'vov A. A. , Shalygina L. S.
Published: October 2015

The article presents information about the international project «Healthy cities», knowledge about principles and axioms of the project. The authors have analyzed the experience of producing the «City Health Profile» under the project WHO «Healthy cities». The authors believe that the «Health Profile» of each individual city varies depending on specific conditions, both physical (the size of the territory, the state of the environment, its location) and political, and socio-economic. However, the formation of the «City Health Profile» is universally, regardless of geographical location or structure. It was noted that the «City Health Profile» has reflected all aspects of the life of the city, facilitates or barriers the promotion of inhabitants’ health and their well-being. For producing of «City Health Profile» additional data are needed: survey, sociological polls of the city population (self-assessment of their health status, lifestyle and quality of life). The advantage of these researches, carried out in the framework of the project «Healthy Cities», is implementation of complex sociological survey with a focused multi-purpose monitoring, covering all spheres of life in the city, to present a versatile, complete and objective evidences to illustrate the city as a territory of health and make up the holistic picture and the centre of which is the citizen and his/her health according to the WHO recommendations.
IMPROVEMENT OF HEALTH CARE FOR PATIENTS WITH UPPER RESPIRATORY TRACT DISEASES ASSOCIATED WITH CHLAMYDIA INFECTION
Authors: Kapustina T. A. , Markina A. N. , Parilova O. V.
Published: October 2015

At present the issues in regard to Chlamydia infection are not only limited by urogenital system. By the way optimal organization and non-urogenital chlamydiosis treatment strategy (with respiratory tract involvement in particular) have not been worked out yet and require immediate solutions. Due to new knowledge on respiratory chlamidiosis the authors discuss scientific background for future development of complex measures and main directions of health care support strategy for patients with upper respiratory associated with Chlamydia infection.
GNOTOBIOLOGY IN MODERN BIO-MEDICAL RESEARCH
Authors: Podoprigora G. I. , Kafarskaya L. I. , Bainov N. A.
Published: October 2015

An overview of the present status and prospects of gnotobiology along with a role of normal microflora studied using laboratory animals with controlled microflora (gnotobiotes) is presented. The principal elements of gnotobiotechnology as well as possibilities of its using in both experimental and clinical investigations are analyzed. A multifaceted role of normal microflora in the host physiology and pathology prejudge the increasing importance of gnotiological models in various fields of biology and medicine, such as the development of new generations probiotics. An assessment and characteristics of selected microbial strains, host-microbe interactions etc. An organization of further complex gnotobiotic research is of prospective value.
HEME OXYGENASE-2 NEURONS BRAIN AND SPINAL CORD OF HUMAN
Authors: Chertok V. M. , Kotsyuba A. E. , Kotsyuba E. P.
Published: October 2015

Immune localization of heme oxygenase-2 in neurons of some nuclei of the spinal cord and brain stem in 6 men 18–44 years old who died from causes unrelated to injury of central nervous system was studied. Neurons with positive reaction are determined for all studied regions of the brain where their contents in various nuclei ranging from 0,5 to 16% of the total number of cells detected by methylene blue. In all the sensory nuclei there is a high proportion of small neurons with a high or moderate density of reaction produc deposits. Large cells of motor nuclei often exhibit negative or low intensive enzyme reaction.
MOLECULAR MECHANISMS OF DEVELOPMENT OF CEREBRAL TOLERANCE TO ISCHEMIA. PART 1
Authors: Shlyakhto E. V. , Barantsevich E. P. , Shcherbak N. S. , Galagudza M. M.
Published: October 2015

In the first part of this review molecular mechanisms of ischemic tolerance emerging as a result of preconditioning of the brain are discussed. Data on inductors, sensors, transducers and effectors of early and delayed ischemic tolerance are presented.
OCCUPATIONAL RISK MANAGEMENT: PROGNOSIS, CAUSATION AND BIOINFORMATIONAL TECHNOLOGIES
Authors: Denisov E. I. , Prokopenko L. V. , Stepanyan S. V.
Published: October 2015

Methodology of occupational risk management is outlined based on workers’ health disorders forecast and causation (work-relatedness assessment). It originates from Labour Code of Russian Federation prescriptions and includes principles, methods and criteria of risk management and risk communication. The methodology is realized by means of bioinformational technologies as expert and analytical system in the form of interactive Web-based directory «Occupational risk assessment» for practical use for occupational risk prevention.