bluuebunny/crossref_metadata_2025 huggingface dataset:
Actividad antimicrobiana de Salvia rosmarinus (romero) sobre Porphyromonas gingivalis y Enterococcus faecalis
Authors: García-Gutiérrez Oscar Manuel , Martínez-Hernández Giovani , Esquibel-Caro Jacqueline , Luna-Roa Citlali , Navarro-Zarza José Eduardo , Reyes-Ríos Roxana
Published: February 2025

El romero (Salvia rosmarinus), es conocida como la reina de las plantas aromáticas, una de sus mayores características además del fuerte aroma es que también es una planta utilizada con fines medicinales por la población en general, la cual ha implementado diversas maneras de consumirla. El propósito de este trabajo fue evaluar la actividad antimicrobiana que tiene el romero, para que con base en esto se pueda considerar para generar diversos productos e inclusive fármacos para su uso específico contra Porphyromonas gingivalis y Enterococcus faecalis. Ya que estas bacterias se han asociado a diversas enfermedades de importancia en el país de México, como la gingivitis y periodontitis. Se determinó la actividad antimicrobiana mediante el método Kirby-Bauer, se realizó la medición de los halos de inhibición formados a partir de los discos impregnados con aceite esencial de romero, el cual mostró actividad contra P. gingivalis y E. faecalis.
Modelos de existencias volumétricas para Neltuma juliflora (Sw.) Raf. en el norte de México
Authors: Valenzuela-Núñez Luis Manuel , Ríos-Saucedo Julio César , Briceño-Contreras Edwin Amir , García-De la Peña Cristina , Melo-Guerrero Enrique , Hernández-Ortiz Juan , Hernández-Valdivia Miriam Susana
Published: February 2025

Los estudios de volumen de madera y productividad de mezquite Neltuma juliflora (Sw.) Raf. son muy importantes debido a que es una de las pocas especies de las zonas semiáridas del norte de México con potencial de aprovechamiento forestal. Los programas de manejo y esquemas de comercialización de madera de mezquite deben sustentarse en estudios realizados de campo para ajustar modelos y estimar el volumen de madera con métodos no destructivos. El objetivo de esta investigación es proponer una metodología rápida y confiable para desarrollar modelos de volumen aplicados a las poblaciones silvestres de mezquite en el norte de México considerando variables de fácil medición como la altura del árbol y el área de la copa. Las ecuaciones desarrolladas en dos sitios de Chihuahua, México resultaron con un alto grado de confiabilidad que pueden servir como base para la generación de modelos específicos para cada sitio.
Identificación de factores de riesgo por estrés generado en alumnos de educación media superior bajo la NOM-035-STPS
Authors: Rocha-Gallegos Abraham , González-Segura Cinhtia Maribel , Varela-Hernández Lourdes del Pilar , Bonilla-Suárez Carlos Benjamín , García-García Michel
Published: February 2025

En los estudiantes de educación media superior el estrés es una problemática que requiere ser analizada y atendida debido a su repercusión a nivel físico, emocional y psicológico. En este trabajo se describe un análisis de la presencia de factores de riesgo en una institución de educación media superior, basado en la aplicación de la NOM-035-STPS. La metodología del estudio tiene un enfoque cuantitativo, descriptivo, transversal, con un muestreo aleatorio y una muestra conformada por 112 estudiantes.  Los resultados indican que durante y después de la pandemia se produjeron algunos factores de riesgo asociados con el estrés relacionados con las cargas de trabajo, aunque el manejo de la comunicación en la escuela ha resultado eficaz y, aunado a los protocolos de seguridad e higiene, se ha logrado salvaguardar la integridad de la comunidad escolar.
Disruptores endocrinos: Sustancias ocultas en la vida diaria que afectan el equilibrio hormonal
Authors: Mora-Vargas Etnia Valeria , Loera-Serna Sandra
Published: February 2025

El sistema endocrino (SE) es responsable del buen funcionamiento del organismo controlando el metabolismo, reproducción, crecimiento, y estado de ánimo. Éste está formado por órganos como la hipófisis, tiroides, paratiroides, glándula pineal y adrenales, que, junto con otras células en otros órganos, regulan funciones fisiológicas mediante la secreción de hormonas. Sin embargo, el funcionamiento del SE puede verse alterado por factores como la edad, medio ambiente, estrés, genética y algunas sustancias a las que estamos expuestos (llamadas disruptores endocrinos, DE). Los DE están presentes en una amplia gama de productos como cosméticos, alimentos, productos de uso personal, textiles, etc. La exposición a estas sustancias puede generar un grave daño endocrino y tener efectos adversos en la salud a largo plazo.
Riesgos psicosociales en México. La confiabilidad de la guía de referencia de la Norma Oficial Mexicana 035
Authors: Domínguez-Aguirre Luis Roberto , Lozano-Jiménez Israel , Briseño-Navarro Juan Carlos , Romero-Guardado César Alí
Published: February 2025

Los riesgos psicosociales han cobrado relevancia debido al interés en preservar la salud física y mental de los trabajadores. Evaluarlos requiere instrumentos validados y confiables. Este artículo analiza las propiedades psicométricas de la Guía de Referencia III de la norma oficial mexicana 035. Se estudió una muestra de más de 700 trabajadores del sector gubernamental, a quienes se aplicó dicho instrumento. Se evaluó la consistencia interna y la estructura teórica mediante índices como GFI, RMSR, RMSEA, NFI, y la Chi cuadrada para validar la parsimonia. Los resultados indicaron una alta consistencia interna (⍺ = .926), pero el análisis factorial confirmatorio reveló un ajuste inadecuado (GFI = .561, RMSR = .129, RMSEA = .083, CFI = .543, c2/gl = 6.008) respecto a la estructura propuesta por la norma, sugiriendo la necesidad de reconsiderar su uso como instrumento psicométrico en su forma actual.
Aplicabilidad de los Smart Contracts
Authors: Varón Quimbayo Angel Alberto , Mina Hinestroza Yenny Marcela
Published: February 2025

Esta investigación pretende presentar la forma como blockchain asocia el desarrollo de Contrato Inteligentes (Smart Contracts), a través de una nueva plataforma que relaciona aspectos éticos, legales, sociológicos y filosóficos que se consideran latentes. Los contratos inteligentes plantean un nuevo protocolo informático el cual garantiza el cumplimiento de cláusulas de un contrato automáticamente, generando una serie de derechos y obligaciones entre las partes intervinientes, actualmente existen varias plataformas para crear y gestionar este tipo de contratos, sin embargo la más recomendada es Ethereum que fue creada específicamente para Smart Contracts. Su objetivo enfoca en que se pueda utilizar en un gran número de servicios en sectores como servicios judiciales, salud, banca, inmobiliario, bolsa de valores entre otros, con la posibilidad de que surjan investigaciones para mejorar la forma cómo se ejecutan los contratos actualmente. en este artículo se describe qué es un contrato inteligente y como se realiza, Qué hace que un contrato sea inteligente, entre otros conceptos que nos ayudaran a entender a mayor profundidad teniendo encueta que el objetivo principal de los Smart Contracts, es mejorar el proceso y la ejecución de los contratos tradicionales, haciéndolos más seguros y económicos, para entender el funcionamiento de los contratos inteligentes es de suma importancia Identificar y analizar el funcionamiento y uso del blockchain ya que es una parte fundamental se basa en la infraestructura Ethereum para hacer posible la ejecución de contratos inteligentes, y como está a aportado y beneficiado la tecnología actualmente. En esta investigación se realizó una búsqueda de artículos científicos, donde se hizo una lectura crítica y analítica para poder emitir juicios de valor y poder construir el artículo, donde se obtuvo como resultado el análisis y la implementación del Smart Contract y cómo estos contribuyen a la promoción de los contratos en general y por último concluimos que los contratos inteligentes se expresan en códigos y que se ejecutan de forma automática, eliminando la necesidad de que existan intermediarios, ofreciendo seguridad y reducción de costes.
Feminicidio y violencia contra la mujer en Colombia
Authors: De La Peña Muñoz Valeria Sofía , Bustos Latorre Laura Dayana , Rincón Moyano Daniela Fernanda , Hernández Neme Nelson Duvan
Published: February 2025

La investigación “Feminicidio y violencia contra la mujer en Colombia” tuvo como fundamento el interés de comprender cómo afectó la pandemia a la sociedad colombiana en cuanto a estos dos delitos, llevándonos a identificar las principales problemáticas y causas que generan un aumento elevado en los casos de feminicidio y la crueldad contra la mujer en momentos de pandemia en el país colombiano. La investigación se realizó con una serie de encuestas dirigidas a 30 mujeres que hayan experimentado algún tipo de violencia en cualquier etapa de su vida y verificar si la violencia contra ellas aumentó en la emergencia sanitaria, se evidencio que la mayoría de mujeres habían sido maltratadas psicológica, verbal o físicamente, donde gran parte de las mujeres aseguro que esto había sido producto del estrés económico que generó el COVID-19. Se concluyó que en época de pandemia la dureza violenta contra la mujer y los feminicidios aumentaron debido a las circunstancias mundiales actuales, como la cuarentena, toque de queda, el home office, donde abren una brecha psicológica en la cual los victimarios pueden desarrollar un mayor grado de estrés y emociones tóxicas las cuales se transforman en violencia, es por esto que desde casa se deben inculcar valores sobre la igualdad y respeto hacia las mujeres, a su vez, implementar mayores medidas de castigo a los agresores por parte de las autoridades y mantener a las mujeres informadas sobre sus derechos y a donde pueden acudir en caso de ayuda.
Estrategias de posicionamiento de marca para pymes
Authors: Hernández Mellizo Paola Andrea , Alvarado Suta Sara Liceth , Jiménez Rubiano Juliana , Moreno Rodriguez Dayana , Rozo Pérez Luisa Fernanda
Published: February 2025

Este artículo tuvo como objetivo principal dar a conocer diferentes estrategias de posicionamiento para lograr resaltar en el mercado, donde se cumplan las diferentes necesidades y deseos de los consumidores. Se abordó la problemática de cómo posicionar y dar visibilidad a una pequeña o mediana empresa en un sector en el cual quiere participar, por lo tanto, para las marcas es importante que se realicen campañas publicitarias con una planificación sólida, para evitar que se genere un posicionamiento erróneo. Se realizó una encuesta a 20 personas utilizando una metodología cualitativa y cuantitativa, por medio de un formulario de Google, donde se analizaron las diferentes opiniones y puntos de vista de emprendedores y empresarios, en cuanto a la importancia de utilizar estrategias de posicionamiento para sus empresas y emprendimientos. Los resultados fueron satisfactorios ya que la mayoría de las personas encuestadas, afirmaron que es necesario llevar a cabo un posicionamiento de marca, resaltando el deseo de implementar métodos que no han puesto en práctica, como estudios de mercado para impulsar su empresa. Así mismo, las personas reconocieron la relevancia de estudiar el público al cual se dirigen, con el fin de generar planes consolidados y con esto, darse a conocer de la manera correcta, también tener ideas de llegar a los clientes de una forma más personalizada y crear el Top Of Mind.
Дослідження стратегій та механізмів прийняття рішень для інтегрованого управління водними ресурсами
Authors:   Східноукраїнський національний університет імені Володимира Даля, Барбарук Ліна
Published: February 2025

Науково-дослідну роботу присвячено вирішенню актуального науково-прикладного завдання підвищення ефективності роботи інформаційно-аналітичних систем моніторингу водних об’єктів завдяки розробці та практичному застосуванню моделей та методів інформаційної технології обробки великих даних. В основу методології дослідження були покладені принципи системного аналізу для декомпозиції процесу обробки великих даних в інформаційно-аналітичних системах моніторингу водних об’єктів; методи пошукового аналізу, технології роботи з літературними джерелами для аналізу перспективних технологій обробки великих даних, оцінювання потенціалу інноваційних технологій моніторингу; методи теоретико-множинного опису, теорії ймовірностей, теорії нечітких множин. У роботі виконано аналітичний огляд сучасних методів і технологій обробки великих даних для кращого управління водними ресурсами. Встановлено, що: (1) незважаючи на інтенсивний розвиток технологій інтелектуального зондування та моніторингу, для багатьох водних ресурсів все ще бракує інтегрованих оцінок на основі великих даних, для підтримки динамічної оцінки якості води, моніторингу та управління наглядом; (2) зростаючі вимоги до даних вимагають збільшення потужності та ефективності інструментів та методів їх обробки. З експоненціальним зростанням даних, традиційні алгоритми видобутку та аналізу даних не можуть в повній мірі задовольнити потреби обробки даних, що обумовлює необхідність розробки і використання нових моделей обробки з розумною обчислювальною вартістю; (3) при візуалізації великих даних, сигнали, що надходять до системи моніторингу можуть бути занадто щільні та розмиті, що призводить до проблем з аналізом тривалих записів не дозволяють швидко орієнтуватися в даних, що вимагає удосконалення технологій візуалізації. За результатами аналізу сучасного стану та тенденцій розвитку систем моніторингу водних об’єктів показано необхідність розробки ефективних моделей і методів інформаційних технологій обробки великих даних. Обґрунтовано проведення досліджень в межах вирішення наступних основних завдань: розробка і використання нечітких моделей для реалізації інтегрованих оцінок води на основі великих даних у реальному часі, удосконалення підходів до нечіткої кластеризації на випадок великих даних, удосконалення технологій візуалізації великих даних, розробка та впровадження інформаційної технології та засобів підтримки прийняття рішень в інформаційно-аналітичній системі моніторингу водних об’єктів. У роботі поставлене та вирішене актуальне науково-прикладне завдання підвищення якості роботи інформаційно-аналітичних систем моніторингу водних об’єктів завдяки розробці та практичному застосуванні моделей та методів інформаційної технології обробки великих даних.
Digital Technologies in Recording Occupational Diseases and their Analysis
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Ziyatdinov M.N. , Tukov A.R. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Mikhailenko A.M. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Archegova M.G. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: February 2025

The article is aimed at the study of digital technology in the sectoral occupational health service. The relevance of the study is due to the changing requirements to the accounting of occupational diseases and their analysis.

The article presents a model of digital health care ‒ the Industry Register of Persons with Occupational Diseases, formulates the tasks, stages of its creation and recommendations for its implementation.

Digital health care is a project that accumulates data on employees with occupational diseases in digital form from health care institutions of FMBA of Russia in order to record and process them and make effective management decisions on their socio-medical rehabilitation.

The development and application of digital health in this direction represents an innovative management system that implies the preservation of professional longevity.

The digital health model in the Sectoral Occupational Health Service was implemented with the exclusion of the existing model, immediately taking over its powers and functions. This implementation process eliminated the loss of information while improving the culture of statistical recording of occupational diseases and their analysis.

In the process of changing the existing system of accounting and reporting in the professional service of the industry, at the same time, information transparency is growing, built on a personal basis, forms a dialog between FMBA of Russia and producers of medical services in health care institutions of the industry.

This technology makes it possible to carry out actual monitoring of professional health of employees of enterprises and institutions serviced by health care institutions of FMBA of Russia, about its trend.
Priority Imaging Technique in Patients with Head and Neck Cancer and Dental Hardware: a Literature Review
Authors:   Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow, Russia, Vasilev Y.A. , Kontorovich D.S. ,   Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow, Russia, Reshetnikov R.V. ,   Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow, Russia, Blokhin I.A. ,   Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow, Russia, Semenov D.S. ,   Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow, Russia
Published: February 2025

Purpose: To systematize the data on the possibilities of head and neck cancer visualization in patients with dental metal constructions using radial diagnostic methods and to choose the most informative one.

Material and methods: We searched for scientific publications in the information and analytical system PubMed up to 2024 inclusive by keywords: metal artifact, head and neck neoplasms, oropharyngeal cancer. A total of 26 articles were analyzed. When choosing the localization of masses, the exclusion criteria were the possibility of using the method and the probable presence of metal structures in the scanning area. The choice of localization was based on the data on the average age of patients with first-diagnosed head and neck neoplasms and extended mainly to the anatomical areas that are most susceptible to artifacts from dental metal structures: the nasopharynx, tongue, and soft tissues of the floor of the mouth.

Results: Studying of the materials allowed to systematize modern data on the possibilities of radial diagnostics in visualization of head and neck tumors in patients with metal structures in the oral cavity and to conclude that the methods of choice in this pathology are PET-CT and MRI with CT, their numerical indices in tumor detection are 89 % for PET-CT and 84% for MRI with CT, respectively. If it is impossible to perform the above methods, it is worth to perform additional examination with the help of additional methods: SCT plus SII, MAR*, dual-energy CT (DECT).

Conclusion: We have performed a comparative analysis in this review of the methods of radial diagnostics that are used to suppress metallic artifacts in patients with TNF OGSS and the most preferable ones are indicated when choosing a scanning method. Thus, the competent choice and consistent application of various methods of radial diagnostics taking into account their capabilities and limitations is a key factor for accurate preoperative assessment of head and neck masses in the presence of artifacts from dental structures in patients.
Sumergido pero no olvidado: herencias culturales bajo el mar en Colombia y su potencial apertura al público
Authors: Del Cairo Hurtado Carlos , López Narváez Andrés , Aldana Mendoza Jesús Alberto , León Rincón Hermann , Caicedo Fernández Alhena , Reina Martínez Carlos
Published: February 2025

Contribución al Debate 31 de revista PH PH 115 (junio, 2025) con título: ¿Se deben abrir los yacimientos arqueológicos subacuáticos para su visita? y coordinado por Filipe Castro, del Centro de Ecología Funcional de la Universidad de Coimbra (Portugal).
Neoliberal Agendas and Global Health Policy: A Political Perspective
Authors: Ozluk Duygu
Published: February 2025

Health is intertwined with politics, as it operates within the sphere of a larger economic, social, and political context. The politics of healthcare encompasses a range of issues, including institutional structures, financial systems, and the interactions among influential stakeholders. Healthcare systems not only reflect the dynamics of society but also promote public health and address health disparities. The impact of neo-liberal policies on health services varies across countries, influenced by the complex interplay between market forces, access to care, and the overall quality of healthcare systems. This study aims to explore the multifaceted effects of neoliberalism on healthcare systems and public health outcomes. By examining the intersection of neoliberal policies, fiscal austerity, privatization, and increased competition within the healthcare sector, this research seeks to provide a comprehensive understanding of how these economic and political ideologies have shaped access to healthcare, the quality of care, health disparities, and the overall well-being of populations.
Science Seborrheic Dermatitis
Authors:   Dental Department, Puli Christian Hospital, Puli, Taiwan, Liao Da-Ming , Chen Chieh ,   2Division of family medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan
Published: February 2025

Seborrheic dermatitis and dandruff are chronic skin diseases of the same category. It is characterized
by skin erythema or plaques with varying degrees of itching and scaling, resulting from a response
to Malassezia species. The affected areas are those with abundant sebaceous glands, such as at the
scalp, face, chest, back, armpits, and groin, where bacteria will break down the skin oil to induce an
inflammatory response. Dandruff is a relatively mild form of seborrheic dermatitis that is characterized
by mild scaling of the scalp without inflammation. .
A horta escolar como um recurso pedagógico nas aulas práticas de Educação Ambiental
Authors: Moura Maria da Conceição Freitas , Silva Pâmela Karla Costa da , Agostinho Ismar Rodrigues , Nogueira Bruna Calígia de Freitas
Published: February 2025

A horta escolar, como ferramenta educacional e pedagógica, possibilita a integração de informações enriquecedoras para os alunos, principalmente no âmbito da Educação Ambiental, que é fundamental na formação de alunos conscientes sobre as questões atuais de proteção do ambiente e qualidade de vida. A presente pesquisa objetivou a implementação de uma horta escolar como ferramenta pedagógica para as aulas práticas de Educação Ambiental com alunos dos 1º anos do curso técnico em Meio Ambiente. O estudo foi desenvolvido no Centro Estadual de Educação Profissional Professor Francisco de Assis Pedrosa (CEEP), no município de Mossoró/RN, em abril de 2024, com o cultivo de hortaliças, como o coentro, alface e cebolinha. Inicialmente, realizou-se a limpeza do terreno, seguida pela preparação dos canteiros, adubação e o plantio. Os adubos orgânicos utilizados foram: pó da casca de ovo, borra de café, esterco, serrapilheira e farinha de osso. Ao longo do desenvolvimento das aulas práticas de Educação Ambiental, pôde-se observar o desempenho dos alunos na construção e desenvolvimento da horta. Os alunos observaram, questionaram e sugeriram melhorias no manejo e cultivo das hortaliças, buscaram formas de trabalhar a sustentabilidade além do espaço escolar, agregando, dessa forma, resultados positivos no meio ambiente. Portanto, foi notório o desempenho, criatividade e conhecimentos dos alunos perante o desenvolvimento e condução da horta. O trabalho mostrou que essa ferramenta pedagógica possibilita a relação no ensino-aprendizagem do aluno nas questões voltadas ao meio ambiente, pois as aulas práticas permitiram uma afetiva assimilação dos educandos com a disciplina de Educação Ambiental.
Eficácia da terapia manual na melhora da dor e amplitude de movimento em pacientes com lombalgia
Authors: Santana Andréia Nascimento , Sampaio Itália de Castro , Reis Luana Araújo dos
Published: February 2025

Introdução: A lombalgia é uma condição prevalente e debilitante que afeta a qualidade de vida dos indivíduos. Classificada como específica ou inespecífica, a lombalgia pode ter origem mecânica, inflamatória ou psicossocial. A terapia manual, que inclui técnicas de manipulação e mobilização, tem sido estudada como uma abordagem eficaz para o tratamento desta condição. Objetivo: Analisar a eficácia da terapia manual no tratamento da lombalgia, com foco na melhora da dor e da amplitude de movimento. Materiais e Métodos: Realizou-se uma revisão narrativa da literatura, com pesquisa em bases de dados eletrônicas como PubMed, BVS, SCIELO e PEDro. Foram incluídos estudos publicados nos últimos cinco anos sobre a aplicação da terapia manual na lombalgia. A análise dos dados seguiu uma abordagem qualitativa descritiva, organizando os achados em categorias temáticas. Resultados: A revisão revelou que a terapia manual, incluindo técnicas de manipulação vertebral e mobilização articular, é eficaz na redução da dor lombar e na melhora da amplitude de movimento. Técnicas como o alongamento miofascial também foram associadas a melhorias na função e na mobilidade dos pacientes. A integração dessas técnicas com intervenções como exercícios físicos e educação do paciente potencializa os resultados. Considerações Finais: A terapia manual apresenta-se como uma abordagem efetiva para o manejo da lombalgia, oferecendo benefícios significativos na redução da dor e na melhoria da função. A abordagem multidisciplinar, que inclui fatores psicossociais e estratégias integradas, é essencial para otimizar os resultados e promover a recuperação funcional a longo prazo.
Evaluation of the agronomic potential of strawberry genotypes (fragaria × ananassa duch) in an organic soilless environment
Authors: Octaveus Matthieu
Published: February 2025

The current scenario in strawberry cultivation is the adoption of the off-ground method in substrate, which reduces the relevance of the planting period in the transplanting process. This study aimed to carry out an agronomic characterization of strawberry genotypes grown out of the ground, under an organic production system. An experimental design with subdivided plots was used for each pair of genotypes, where the plots represented the genotypes themselves and the subplots represented the months of evaluation. Each genotype was evaluated in three replicates, totaling 18 plants in each. The evaluations included phenological aspects, commercial classification, coloring, plant characterization, and production aspects. The data was analyzed using variance, with differences between means evaluated using the Tukey test at 5% probability. Throughout the evaluations, DN3 outperformed DN6 in terms of diameter, number of fruits, production and chlorophyll content, while being phenologically later. Among the short-day genotypes, DC10 stood out with greater diameter, chlorophyll content and production at harvest, demonstrating precocity in relation to DC01. However, due to the late planting, the production of the short-day genotypes was lower than expected, revealing a more significant impact of this practice.
Efeito das proteínas do látex de Plumeria pudica na mucosite intestinal induzida por 5-fluorouracil em camundongos
Authors: Andrade Gabriella Linhares de , Souza Bruna da Silva , Sales Ana Clara Silva , Silva Francisca Dayane Soares da , Souza Thalis Ferreira de , Oliveira Ana Patrícia de , Medeiros Jand Venes Rolim , Souza Leonardo Peres de , Barreto Andressa Freitas dos Santos , Araújo Ana Jérsia , Marinho Filho José Delano Barreto , Souza Jéssica Maria Teles , Oliveira Jefferson Soares de
Published: February 2025

A Plumeria pudica produz um látex rico em proteínas (PLPp) com propriedades anti-inflamatórias, antinociceptivas e antidiarreicas, além de reduzir a periodontite e atuar como protetor na colite ulcerativa. O presente estudo teve como objetivo avaliar os efeitos das proteínas do látex na mucosite intestinal induzida por 5-fluorouracil, de forma a contribuir com informações significativas para a solução desse problema e, se possível, tornar-se uma ferramenta terapêutica para a mucosite intestinal. Para tal, fêmeas de camundongos da linhagem Balb/c foram divididas em três grupos: salina, 5-FU e PLPp + 5-FU. A mucosite foi induzida com três doses de 5-FU, enquanto o PLPp foi administrado uma hora antes de cada aplicação do quimioterápico, por três dias. O intestino delgado foi coletado para análises histopatológicas, morfométricas, de estresse oxidativo (MDA, GSH e SOD) e inflamatórias (MPO e NO3/NO2). A citotoxicidade in vitro do PLPp foi avaliada isoladamente e combinado ao 5-FU. A PLPp reduziu os níveis de MPO e NO3/NO2, demonstrando uma ação anti-inflamatória, embora não tenha revertido as alterações histopatológicas. Além disso, a PLPp não apresentou citotoxicidade nas células HCT 116 testadas, e sua associação com o 5-FU não reduziu a CI50 do quimioterápico. Concluiu-se que o PLPp protege a mucosa intestinal contra o estresse oxidativo e a inflamação induzidos pelo 5-FU, embora sua atividade proteolítica pode comprometer a eficácia farmacológic.
Indutores de resistência no controle de doenças na cultura do trigo: Uma revisão de literatura acerca do conteúdo
Authors: Blanca Thalya Costa , Martins Juliana Araújo Santos
Published: February 2025

Quando se fala sobre a qualidade do grão de trigo, é comum relacionar esse aspecto a diversas condições de cultivo, incluindo características do solo, temperatura, umidade, presença de doenças e o manejo da cultura. Todos esses fatores têm um impacto direto no uso industrial do produto final. Por isso, é essencial prevenir e controlar as doenças que afetam essa cultura, buscando substâncias que tornem o manejo mais eficiente e econômico. Nesse contexto, a indução de resistência em plantas de trigo pode ajudar a diminuir a incidência de doenças e aumentar a produtividade. O objetivo desta pesquisa foi conduzir uma revisão bibliográfica e analisar pesquisas disponíveis na literatura sobre a utilização de indutores de resistência no controle de doenças na cultura do trigo. Os estudos demonstram que o uso de elicitores contribui para o aumento da altura das plantas, para a produção de grãos de melhor qualidade, e ainda melhoria no vigor das plantas. Todos os estudos apontados, argumentam que a adubação silicatada é uma alternativa que promove bons resultados. Além disso, a adubação de silício combinada com bioestimulantes promovem resultados ainda mais significativos. Recomenda-se que pesquisas futuras explorem ainda mais o desempenho de indutores de resistência contra patógenos na cultura do trigo, já que evidências indicam resultados positivos.
The CMB Temperature is Simply the Geometric Mean: T_cmb = Sqrt(T_min*T_max) of the Minimum and Maximum Temperature in the Hubble Sphere
Authors: Haug Espen
Published: February 2025

In the Hubble sphere, we assume that the wavelength of pure energy spreads out in all directions. The maximum wavelength in the Hubble sphere is then the circumference of the Hubble sphere. We assume the minimum wavelength occurs in a Planck mass black hole, which is given by 4pi R_{s,p}=8pi*l_p. Here, we build further on the geometric mean CMB approach by Haug and Tatum and conclude that the CMB temperature is simply given as: T_cmb=Sqrt(T_min*T_max), which is the geometric mean of the minimum and maximum physically possible temperatures in the Hubble sphere. This is again means the CMB temperature simply is the geometric mean of the Hawking temperature of the Hubble sphere (in black hole cosmology) and the Hawking temperature of the Planck mass black hole, se we have also T_cmb=Sqrt(T_{Haw,H}*T_{Haw,p)).
COMMENTS Angelika S. Arutyunyan, Petr A. Yartsev, Dmitry A. Blagovestnov, Nikolai V. Karulin Treatment of colon perforations after laparoscopic shaving of endometrioid foci of the colon (case report)
Authors: Editorial Article
Published: February 2025

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Does the parastomal hernia rate depend on the method of stoma formation? (meta-analysis and review)
Authors: Chernyshov S. V. , Khilkov Yu. S. , Abdullayeva N. S. , Moskalev A. I.
Published: February 2025

AIM: to compare the effectiveness of different techniques for parastomal hernia prevention.MATERIALS AND METHODS: a systematic review and meta-analysis were performed in accordance with the PRISMA recommendations for the entire period up to 09/08/2023. The search for papers is carried out in PubMed with keywords “extraperitoneal”, “transperitoneal”, “intraperitoneal”, “rectal cancer”, “abdominoperineal resection”, “parastomal hernia”, “colostomy”, “stoma”, “end colostomy”, “prophylactic mesh”, “mesh”. As a result of the literature selection, 28 studies were included in the meta-analysis — 15 studies for end colostomy with and without an implant; 5 studies comparing intra-abdominal and extraperitoneal end colostomy; 8 studies comparing stoma channels through the rectus abdominis shield (transrectal stoma) and lateral stoma.RESULTS: the incidence of parastomal hernias is significantly lower for extraperitoneal stoma (p = 0.05) than intraabdominal one (OR = 3.40, CI 1.01–11.44) without significant increase in postoperative morbidity rate (OR = 1.04, CI 0.53–2.02, p = 0.92, OR = 2.22, CI 0.67–7.30, p = 0.19). Mesh significantly decreases the incidence of parastomal hernias (OR = 1.87, CI 1.16–3.01, p < 0.0001) without a consistent increase in postoperative morbidity rate (OR = 0.93, CI 0.47–1.82, p = 0.82). No significant differences were obtained between lateral and transrectal colostomies in the incidence of parastomal hernia (OR = 1.14, CI 0.52–2.52, p = 0.74).CONCLUSION: the extraperitoneal colostomy and meshes reduce the risk of parastomal hernia.
Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank
Authors: Sun Wanwan , Lin Ruilang , Li Yiming , Yao Ye , Lu Bin , Yu Yongfu
Published: February 2025

Objective

To investigate the relationship between circulating branched-chain amino acids (BCAAs) and the risk of major adverse cardiovascular events (MACE) in a national population-based cohort study.

Methods

UK Biobank, a prospective study involving 22 recruitment centers across the United Kingdom. For this analysis, we included 266,840 participants from the UK Biobank who had available BCAA data and no history of MACE at baseline. Cox regression analysis was conducted to evaluate these associations, adjusting for potential confounders.

Results

During a 13.80 ± 0.83-year follow-up, 52,598 participants experienced MACE, with the incidence of MACE increasing progressively across quintiles of circulating BCAAs, isoleucine, leucine, and valine. Overall, the fifth quintile exhibited a 7-12% higher MACE risk compared to the second quintile. In males, BCAAs were not associated with MACE risk. However, increased risks were observed for isoleucine (8-12% in higher quintiles), leucine (9% in the first quintile and 6% in the fifth quintile), and valine (8% in the first quintile). In females, higher quintiles of BCAAs, isoleucine, leucine, and valine were associated with increased MACE risk, ranging from 9% to 12%. Among participants under 65y, higher quintiles of BCAAs, isoleucine, and leucine were associated with increased MACE risk, while valine showed no significant association. No association was found in participants aged 65 and older. These analyses were adjusted for multiple potential confounders.

Conclusion

Generally, higher levels of BCAAs, isoleucine, leucine, and valine were associated with an increased risk of MACE, except in participants older than 65. Additionally, in males, the lowest quintiles of leucine and valine were also associated with an increased risk of MACE.
Single-cell analysis of CD14+CD16+ monocytes identifies a subpopulation with an enhanced migratory and inflammatory phenotype
Authors: Ruiz Vanessa Y. , Calderon Tina M. , Leon-Rivera Rosiris , Chilunda Vanessa , Zhang Jinghang , Berman Joan W.
Published: February 2025

Monocytes in the central nervous system (CNS) play a pivotal role in surveillance and homeostasis, and can exacerbate pathogenic processes during injury, infection, or inflammation. CD14+CD16+ monocytes exhibit diverse functions and contribute to neuroinflammatory diseases, including HIV-associated neurocognitive impairment (HIV-NCI). Analysis of human CD14+CD16+ monocytes matured in vitro by single-cell RNA sequencing identified a heterogenous population of nine clusters. Ingenuity pathway analysis of differentially expressed genes in each cluster identified increased migratory and inflammatory pathways for a group of clusters, which we termed Group 1 monocytes. Group 1 monocytes, distinguished by increased ALCAM, CD52, CD63, and SDC2, exhibited gene expression signatures implicated in CNS inflammatory diseases, produced higher levels of CXCL12, IL-1Ra, IL-6, IL-10, TNFα, and ROS, and preferentially transmigrated across a human in vitro blood-brain barrier model. Thus, Group 1 cells within the CD14+CD16+ monocyte subset are likely to be major contributors to neuroinflammatory diseases.
Identification of DAP3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma
Authors: Yuan Liu-Xia , Yue Zhi-Qiang , Ma Qin-Rong , Zhang Peng , Xiao Feng , Chen Lin
Published: February 2025

Background

Among malignant tumors, hepatocellular carcinoma (HCC) is both prevalent and highly lethal. Most patients with advanced-stage liver cancer have a poor prognosis. Death-associated protein 3 (DAP3) is reportedly related to tumors and may hold great promise for the future.

Methods

DAP3 transcriptome data along with related clinical information were obtained from The Cancer Genome Atlas (TCGA), GEO, and ICGC databases. We assessed its prognostic value, clinical relevance, associated pathways, immune infiltration, gene mutations, and sensitivity to chemotherapeutics. A prognostic risk model was subsequently developed and evaluated using receiver operating characteristic (ROC) curves and Kaplan-Meier (KM) plots. Additionally, a nomogram was created and validated through calibration and decision curve analysis (DCA). Furthermore, quantitative real-time PCR (qRT-PCR), Western blot, and immunohistochemical (IHC) staining were performed to examine the expression of DAP3 in HCC. Finally, gene knockdown and overexpression experiments, along with cell counting kit-8 (CCK-8) assays, colony formation assays, and tests for cell apoptosis, migration, and invasion, were conducted to investigate the role of DAP3 in HCC.

Results

The study discovered that DAP3 expression was linked to HCC subtypes, and its high expression was linked to a poor prognosis. There were significant differences in immune infiltration level, mutation level, prognostic value and chemotherapeutic efficacy. Subsequently, we constructed a prognostic model and demonstrated that high risk score was significantly related to a poor survival rate. A predictive nomogram demonstrated that the nomogram model was effective prediction tool that can accurately predict the survival rate of patients with different clinical characteristics. Additionally, DAP3 expression significantly increased in both tissue samples and cell lines. Elevated levels of DAP3 were correlated with larger tumor size and higher alpha-fetoprotein (AFP) levels, and Cox analysis confirmed that DAP3 was a clinically independent prognostic marker. Finally, cell assays revealed that the knockdown of DAP3 significantly impeded cell proliferation and metabolic activity and induced apoptosis. Conversely, the overexpression of DAP3 had opposite effects on these cellular processes.

Conclusions

Our study on DAP3 can provide a reference for HCC diagnosis, treatment and prognosis assessment.
AI applications in HIV research: advances and future directions
Authors: Jin Ruyi , Zhang Li
Published: February 2025

With the increasing application of artificial intelligence (AI) in medical research, studies on the human immunodeficiency virus type 1(HIV-1) and acquired immunodeficiency syndrome (AIDS) have become more in-depth. Integrating AI with technologies like single-cell sequencing enables precise biomarker identification and improved therapeutic targeting. This review aims to explore the advancements in AI technologies and their applications across various facets of HIV research, including viral mechanisms, diagnostic innovations, therapeutic strategies, and prevention efforts. Despite challenges like data limitations and model interpretability, AI holds significant potential in advancing HIV-1 management and contributing to global health goals.
Prediction of hearing aid cognitive outcomes in age-related hearing loss
Authors: Voss Patrice , Martinez-Moreno Zaida Escila , Prévost Francois , Zeitouni Anthony , Lopez Valdes Alejandro , de Villers-Sidani Etienne
Published: February 2025

Although the phenomena underlying cognitive decline and dementia are complex, there is growing evidence suggesting that degraded sensory inputs caused by age-related hearing loss may play a central role in accelerating cognitive decline in older individuals. Further supporting this notion is evidence that hearing augmentation with hearing aids can mitigate hearing loss-related cognitive impairments. Despite this evidence, few studies have attempted to investigate hearing aid efficacy with a focus on cognitive outcome measures. In this preliminary study, we sought to determine if certain demographic and audiological factors are linked to individual differences regarding observed cognitive changes following hearing aid use. We show that several factors can explain large portions of the variance observed in cognitive score changes following short-term hearing aid use in first-time users, suggesting that it might be possible to develop predictive algorithms to determine individualized estimates of the cognitive benefit of hearing aid use. Future studies with larger sample sizes are warranted, in particular, to explore a wider array of cognitive functions, investigate a greater range of potential predictors, and better quantify their relative contribution to outcome measure estimates.
Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study
Authors: Zhao Han-Qing , Lv Jia-Le , Gao Yuan-Zhi , Hu Bo , Du Zong-Da , Wang Yan , Wang Mei-Lin , Hou Meng-Di , Li Fang , Xing Xue , Sun Ming-Hui
Published: February 2025

Background

The inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. However, the relationship between inflammation score and cardiovascular disease (CVD) is unclear. Thus, we aimed to explore the association of inflammatory score with CVD, as well as to evaluate whether adhering to a healthy lifestyle could alleviate this association.

Methods

We analyzed 6,164 participants aged ≥45 years who entered a prospective cohort study of the China Longitudinal Study of Health and Retirement (CHARLS) between 2011 and 2012 and were followed up for CVD incidence untill 2018. The inflammatory score was measured by summing of the Z-scores for C-reactive protein and white blood cell count at baseline. The healthy lifestyle score was calculated by four factors, smoking status, alcohol consumption, body mass index, and sleep duration. Cox proportional hazard models were utilized to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of CVD.

Results

During the 7-year follow-up period, there were 761 incident cases of CVD. Compared with the lowest tertiles, the highest inflammatory score was associated with an elevated risk of CVD (HR = 1.25, 95% CI = 1.04–1.49). Compared to the unhealthy lifestyle, participants adhered to a healthy lifestyle was inversely associated with CVD risk (HR = 0.74, 95% CI = 0.60–0.93). Of note, when participants adhered to a healthy lifestyle, the higher inflammatory score was no longer significantly correlated with CVD risk (HR = 1.00, 95% CI = 0.76–1.34). Additionally, a multiplicative interaction was detected between inflammatory score and healthy lifestyle score for CVD risk (p interaction <0.05).

Conclusion

The inflammation score was associated with higher risk of CVD incidence, but adherence to a healthy lifestyle may mitigate the adverse association of inflammation score and CVD among the middle-aged and older participants.
Targeted treatment and survival in advanced non-squamous non-small cell lung cancer patients – a nationwide and longitudinal study
Authors: Nyen Johanne Elise , Booth Anja Ødegård , Husby Øyvind , Bugge Christoffer , Engebretsen Ingrid , Oteiza Francisco , Helland Åslaug , Fjellbirkeland Lars , Brustugun Odd Terje , Grønberg Bjørn Henning
Published: February 2025

Objectives

We aimed to describe treatment patterns, time on treatment (ToT) and overall survival (OS) for patients with advanced non-squamous, EGFR+, ALK+ and ROS1+ NSCLC in Norway.

Materials and methods

We extracted data on patients ≥ 18 years diagnosed with advanced non-squamous NSCLC between 2015 and 2022 from the Cancer Registry of Norway and data on cancer drug therapy from the Norwegian Patient Registry and the Norwegian Prescribed Drug Registry. ToT was measured from the date treatment was collected or administered until the last dispensing was depleted or last hospital drug administration. OS was measured from date of diagnosis until death.

Results

In total, 5,279 patients were included, of whom 449 EGFR+, 131 ALK+ and 38 ROS1+. 75% of EGFR+ patients, 88% of ALK+ patients, and 58% of ROS1+ patients received at least one systemic treatment within the first three months after diagnosis. Median follow-up was 13, 19, and 4 months for EGFR+, ALK+, and ROS1+, respectively. The median ToT in first line (1L) for EGFR+ patients was 11 months for osimertinib (CI: 10.1-NA) and 9 months (CI: 8.2-11.2) for afatinib, dacomitinib, erlotinib and gefitinib. For ALK+ patients, median ToT in 1L was 20 months (CI: 14.7-23.7for alectinib, 11 months (CI: 4.7-NA) for brigatinib, and 7 months (CI: 2.9-21.6) for crizotinib. For the five ROS1+ patients treated with crizotinib in 1L, median ToT was 5 months (CI: 2.4-NA). For all patients with a targetable genomic alteration, unadjusted median OS was higher (p-value = 0.025) for patients diagnosed in 2020-2022 (median OS: 23 months, CI: 19.5-NA) compared to patients diagnosed in 2015-2019 (median: 19 months, CI: 16.5-21.2).

Conclusions

ToT for targeted therapies was shorter than progression-free survival in clinical trials. However, patients eligible for targeted therapy still had a survival improvement during the study period.