bluuebunny/crossref_metadata_2025 huggingface dataset:
El efecto de la implementación de la guía informativa de alta en el cumplimiento de las indicaciones de cuidados puerperales y cuidados del recién nacido de las puérperas mediatas atendidas en el servicio de adolescencia en el Instituto Nacional Materno P
Authors: Admin Admin , Hinojosa-Ruelas Aydee , Paiva-Pacaya Ana Clarice , Ruiz-Aguilar Celinda Paola , Salazar-Torres Jessica Mariela
Published: January 2019

Objetivos. Determinar el efecto de la implementación de la guía informativa sobre el cumplimiento de las indicaciones de cuidados puerperales y del recién nacido de las puérperas mediatas adolescentes atendidas en el servicio de adolescencia del Instituto Nacional Materno Perinatal-2012. Materiales y métodos. Estudio cuasi-experimental, prospectivo, comparativo, se contó con un grupo experimental y un grupo comparativo. Se evaluaron a 120 puérperas a razón de 60 puérperas adolescentes en cada grupo, divididas en dos grupos: Grupo A, pacientes a las que se aplicó una guía informativa y grupo B pacientes a las cuales no se les aplicó la guía informativa, todas atendidas en el INMP desde octubre 2011 a febrero 2012. Se estimó para las variables cualitativas las frecuencias absolutas y relativas. Para el caso de variables cuantitativas se estimaron las medidas de tendencia central como media, mediana, y medidas de dispersión como desviación estándar y rango. Para el análisis inferencial se utilizó la prueba t de student para muestras independientes y prueba de independencia chi cuadrado. Resultados. Mayoría de pacientes procedían de los distritos de SJL 31,7%, SJM 11,7% y Villa el Salvador 10%; edad promedio 16,72 ± 1,3 años; 80% tuvieron educación secundaria; 70% fueron convivientes. El 63,3% de los partos fue vaginal y el 36,7% por cesárea; estancia hospitalaria promedio fue 3,43 ± 1,5 días. En el grupo que se aplicó la guía de orientación se alcanzó el 63,3% de cumplimiento calificado como “Muy bueno”, comparado con el 6,7% del grupo que no se aplicó la guía de orientación. El nivel de cumplimiento sobre los cuidados del recién nacido se alcanzó el 66,7% de cumplimiento calificado como “Muy bueno” comparado con el 16,7% del grupo control, observándose que existe un efecto positivo de la implementación de la guía de informativa de alta en el cumplimiento de las indicaciones y cuidados puerperales, encontrándose relación entre ambas variables (p<0,001). Asimismo, existe un efecto positivo de la implementación de la guía de informativa de alta en el cumplimiento de las indicaciones y cuidados del recién nacido, relacionándose ambas variables (p<0,001). Conclusiones. El nivel de cumplimiento de la guía de orientación sobre el cuidado puerperal y del recién nacido alcanzó efecto positivo relevante.
Pautas para el diagnóstico de la diabetes mellitus gestacional
Authors: Admin Admin , Larrabure-Torrealva Gloria
Published: January 2019

La diabetes gestacional es la alteración del metabolismo de los hidratos de carbono, de severidad variable, que comienza o se reconoce por primera vez durante el embarazo.

La búsqueda de diabetes en el embarazo debe hacerse desde el primer nivel de atención, en toda embarazada, presente o no factores de riesgo, de acuerdo a los recursos disponibles y es conveniente realizarla el tamizaje mediante una Prueba de Tolerancia Oral a la Glucosa (PTOG) a las 24-28 semanas de gestación.
Factores asociados a la reducción de la hemoglobina en puérperas atendidas en el Instituto Nacional Materno Perinatal – 2012
Authors: Díaz-Tinoco Clara
Published: January 2019

Objetivo. Analizar los factores que se asocian a la reducción de los niveles de hemoglobina en puérperas atendidas en el Instituto Nacional Materno Perinatal durante el año 2012. Materiales y Métodos. Estudio de casos y controles donde se asignó a 274 pacientes puérperas divididas en 137 con diferencia de hemoglobina M ,3 g/dl (casos) y 137 con diferencia de hemoglobina <1,3 g/dl (controles). Se aplicó estadísticas descriptivas e inferenciales, medidas de tendencia central y de dispersión en las variables cuantitativas, distribución de frecuencias para las variables cualitativas, para las inferencias estadísticas se aplicó Chi cuadrado, OR IC al 95% y regresión logística binaria para el análisis multivariado.
Evaluación de la capacidad antagonista de un antimicrobiano producido por Streptomyces sp cepa 13a-2 frente a microorganismos resistentes a B-lactámico de origen hospitalario
Authors: Lino-Navarro Mirko , León-Quispe Jorge , Huamán-Iturrizaga Mónica
Published: January 2019

Objetivo. Evaluar la actividad antimicrobiana in vitro del actinomiceto marino cepa 13A-2 frente a enterobacterias productoras de P-lactamasas aisladas de pacientes con infecciones urinarias. Material y Métodos. Mediante la técnica de doble capa se selecciono el actinomiceto con la mayor actividad antagonista frente a 16 enterobacterias de los géneros Klebsiella sp., Proteus sp. y E. coli, productoras de betalactamasas de pacientes con infección urinaria del Instituto Materno Perinatal de Lima. La cepa 13-A2, aislada de una esponja marina colectada del litoral peruano, fue identificada molecularmente por amplificación del gen que codifica ARNr 16S La naturaleza peptídica del antimicrobiano se determinó mediante las técnicas de Bradford, Qubit fluoremeter, PAGE-SDS y HPLC. Se logró cuantificar la producción del antimicrobiano utilizando un nuevo medio de cultivo propuesto por el autor el cual fue comparado con caldo marino.
Sangrado uterino anormal en la postmenopausia: diagnóstico y manejo
Authors: Ayala-Peralta Félix , Rodriguez-Herrera Miguel Angel , Izaguirre-Lucano Humberto , Ayala-Palomino Richard , Quiñones-Vásquez Luis Alberto , Ayala-Moreno Dasio , Luna-Figueroa Antonio
Published: January 2019

En la mujer postmenopáusica la presencia de sangrado uterino anormal en forma espontánea e inesperada requiere evaluación rigurosa para determinar el origen de dicho sangrado. La causa más común de sangrado postmenopáusico es la atrofia endometrial y pólipo endometrial; sin embargo, es necesario descartar cáncer endometrial que es la causa en aproximadamente el 10 por ciento de pacientes. El estándar de oro para evaluar el endometrio es la ultrasonografía transvaginal y la biopsia endometrial, que son dos componentes claves que ayudan a llegar a un diagnóstico certero.
Valores de referencia del índice de pulsatilidad de la arteria cerebral media en fetos sanos entre las 20 a 40 semanas en Lima- Perú
Authors: Limay-Ríos Oscar Antonio , Calixto-Coronel Roxana Guadalupe , Ingar-Pinedo Jaime , Huertas-Tacchino Erasmo , Castillo-Urquiaga Walter , Ventura-Laveriano Walter , Zarate-Girao Mario
Published: January 2019

Objetivo: Establecer valores de referencia del índice de pulsatilidad de la arteria cerebral media en fetos sanos. Método: Es unestudio descriptivo, retrospectivo y transversal realizado en el Instituto Nacional Materno Perinatal en el periodo 2014 al 2016.Seregistraron 1865 mujeres con embarazo único y bajo riesgo entre las 20 a 40 semanas de gestación y se le realizaron examenDoppler de la arteria cerebral media fetal.
Anestesia para cesárea en paciente con acondroplasia
Authors: Calderón-Lozano Marjorie Lisseth , Capatinta-Mamani César , Vásquez-Yeng Jackeline Dayang
Published: January 2019

Objetivo. Describir el manejo anestésico de una paciente con acondroplasia programada para cesárea electiva, empleandola anestesia espinal.
Detemination of The Best Method (HF, MP2 and B3LYP) in Calculation of Chemical Hardness
Authors: ZAİM Zinet , ALAGÖZ SAYIN Tuba , SAYIN Koray , KARAKAŞ Duran
Published: January 2019

Chemical hardness of 62 molecules are calculated at different 18  levels. No imaginary frequency is observed in optimization results for each level. Correlation between experimental and calculated hardness values are investigated. To analyze this investigation, correlation coefficient and scale factor are calculated for each level. As a result, HF method is better in the calculation of chemical hardness and molecular orbital energy than B3LYP and MP2 methods.
QSAR Studies of amino-pyrimidine derivatives as Mycobacterium tuberculosis Protein Kinase B inhibitors
Authors: Khamoulı Saida , Belaıdı Salah , Belaıdı Houmam , Belkhırı Lotfi
Published: January 2019

Quantitative structure activity relationship (QSAR)
analysis was applied to a series of amino-pyrimidine derivatives as PknB
inhibitors using a combination of various physicochemical and quantum
descriptors. A multiple linear regression (MLR) procedure was used to model the
relationships between molecular descriptors and the chemotherapeutic activity
of the amino-pyrimidine derivatives. Good agreement between experimental and
predicted activity values, obtained in the validation procedure, indicated the
good quality of the derived QSAR model. The statistically
significant best QSAR model has a cross validated correlation coefficient R2CV=
0.973 and external predictive ability of prediction R2 = 0.778 was
developed by MLR. The proposed model has good robustness and
predictability when verified by internal and external validation.
ŞANTİYELERİN İŞ SAĞLIĞI VE GÜVENLİĞİ AÇISINDAN RİSK DÜZEYLERİNE GÖRE KEMIRA-M YÖNTEMİ İLE SIRALANMASI
Authors: TOKTAŞ Pelin , CAN Gülin Feryal
Published: January 2019

İnşaat sektörü diğer
sektörler ile karşılaştırıldığında iş kazalarının yaşanma sıklığı ve bu
kazaların sonuçlarının ağırlığı açısından ilk sırada yer almaktadır. Bu nedenle
şantiyelerde iş sağlığı ve güvenliği açısından risk düzeyinin belirlenerek bu
düzeyin düşürülmesi önem taşımaktadır. Risk düzeyi belirlenirken birçok
faktörün gerçek değerleri ile dikkate alınması, uzman görüşlerinden
faydalanılması ve risk faktörlerinin olası riskler ile ilişkileri büyük önem
taşımaktadır. Büyük ölçekli inşaat firmaları açısından düşünüldüğünde ise
birden fazla şantiye için risk düzeyi açısından önceliklendirmenin yapılması ve
önleme çabalarının en riskli şantiyeye odaklanması firma açsından fayda
sağlayacaktır. Bu kapsamda çalışmada, nitel ve nicel kriterlerle çalışabilen ve
aynı zamanda uzmanların görüşlerini de dikkate alan çok kriterli karar verme
yöntemlerinden birisi olan KEMIRA-M (Modified KEmeny Median Indicator Ranks
Accordance) yöntemi şantiyelerin risk düzeyi açısından sıralamalarının
yapılması amacıyla kullanılmıştır. Çalışmada, kriterler sayısal göstergeler ve
tedbir göstergeleri olmak üzere iki gruba ayrılmıştır. İş kazası sayısı, kayıp
gün sayısı, toplam çalışan sayısı ve toplam çalışılan gün sayısı sayısal
göstergeleri oluştururken iş sağlığı ve güvenliği eğitimlerinde harcanan süre,
iş sağlığı ve güvenliği eğitimi alan işçi sayısı ve iş sağlığı ve güvenliği
denetimi sayısı tedbir göstergelerini oluşturmaktadır. Söz konusu kriterlerin ve
4 iş sağlığı ve güvenliği uzmanının değerlendirmelerinin dikkate alınmasıyla
bir inşaat firmasının 9 farklı şantiyesi sıralanmıştır. Kriterlerin uzmanlar
tarafından önem sıralamaları belirlenirken, şantiyelerde yaşanabilecek risk
türleri açısından kriterlerin yaratabilecekleri etkilerin de değerlendirmeye
alınması amacıyla kalite yayılım fonksiyonu (Quality Function Deployment-QFD)’dan
yararlanılmıştır. Çalışma, iş sağlığı ve güvenliği uzmanlarına karar verme
sürecinde destek olabilecek bir nitelik taşımaktadır.
Characterization of Bioactive Compounds, Mineral Content, and Antioxidant Activity in Bean Varieties Grown with Traditional Methods in Oaxaca, Mexico
Authors: Armendáriz-Fernández Karen Vanesa , Herrera-Hernández Ibeth Marlene , Muñoz-Márquez Ezequiel , Sánchez Esteban
Published: January 2019

The aim of the current study is to characterize the bean varieties produced in the State of Oaxaca (Mexico) with the purpose of selecting varieties with the potential of being biofortified with micronutrients. Eleven bean varieties representative of the State of Oaxaca (Mexico) were harvested, the color was characterized and the physicochemical analysis, mineral content, antioxidant capacity, reducing power, and bioactive compounds were determined. Data obtained were subjected to a variance analysis for the difference between the means of the bean varieties studied through the 95% Tukey test. The results obtained show the significant difference was found among the 11 bean varieties harvested in Oaxaca (México). The analysis found five outstanding varieties with a larger quantity of favorable characteristics on the iron, zinc, protein content, antioxidant capacity and reducing power. The outstanding varieties relating Fe and Zn content were Michigan for Fe 67.4 ppm, Sangre de Toro 62.4 ppm, which showed the larger content of antioxidant capacity (82.12%) scavenging activity and Biche for Zn 34.7 ppm. The variety with a larger quantity of protein (26.66%) was Biche bean, followed by the Peruano bean with 24.91% of protein. The variety with larger content of reducing power 0.16% was Blanco Michigan bean. Lastly, it is also remarkable that such outstanding bean varieties are important to include in a biofortification program with micro-nutrients to improve the food safety and the nutrition in vulnerable communities of the urban and rural sector of Oaxaca (Mexico).
Mid-Infrared Tunable Laser-Based Broadband Fingerprint Absorption Spectroscopy for Trace Gas Sensing: A Review
Authors: Du Zhenhui , Zhang Shuai , Li Jinyi , Gao Nan , Tong Kebin
Published: January 2019

The vast majority of gaseous chemical substances exhibit fundamental rovibrational absorption bands in the mid-infrared spectral region (2.5–25 μm), and the absorption of light by these fundamental bands provides a nearly universal means for their detection. A main feature of optical techniques is the non-intrusive in situ detection of trace gases. We reviewed primarily mid-infrared tunable laser-based broadband absorption spectroscopy for trace gas detection, focusing on 2008–2018. The scope of this paper is to discuss recent developments of system configuration, tunable lasers, detectors, broadband spectroscopic techniques, and their applications for sensitive, selective, and quantitative trace gas detection.
Titanium Dioxide (TiO2) Mesocrystals: Synthesis, Growth Mechanisms and Photocatalytic Properties
Authors: Zhang Boxue , Cao Shengxin , Du Meiqi , Ye Xiaozhou , Wang Yun , Ye Jianfeng
Published: January 2019

Hierarchical TiO2 superstructures with desired architectures and intriguing physico-chemical properties are considered to be one of the most promising candidates for solving the serious issues related to global energy exhaustion as well as environmental deterioration via the well-known photocatalytic process. In particular, TiO2 mesocrystals, which are built from TiO2 nanocrystal building blocks in the same crystallographical orientation, have attracted intensive research interest in the area of photocatalysis owing to their distinctive structural properties such as high crystallinity, high specific surface area, and single-crystal-like nature. The deeper understanding of TiO2 mesocrystals-based photocatalysis is beneficial for developing new types of photocatalytic materials with multiple functionalities. In this paper, a comprehensive review of the recent advances toward fabricating and modifying TiO2 mesocrystals is provided, with special focus on the underlying mesocrystallization mechanism and controlling rules. The potential applications of as-synthesized TiO2 mesocrystals in photocatalysis are then discussed to shed light on the structure–performance relationships, thus guiding the development of highly efficient TiO2 mesocrystal-based photocatalysts for certain applications. Finally, the prospects of future research on TiO2 mesocrystals in photocatalysis are briefly highlighted.
The Use of Zeolites for VOCs Abatement by Combining Non-Thermal Plasma, Adsorption, and/or Catalysis: A Review
Authors: K. P. Veerapandian Savita , De Geyter Nathalie , Giraudon Jean-Marc , Lamonier Jean-François , Morent Rino
Published: January 2019

Non-thermal plasma technique can be easily integrated with catalysis and adsorption for environmental applications such as volatile organic compound (VOC) abatement to overcome the shortcomings of individual techniques. This review attempts to give an overview of the literature about the application of zeolite as adsorbent and catalyst in combination with non-thermal plasma for VOC abatement in flue gas. The superior surface properties of zeolites in combination with its excellent catalytic properties obtained by metal loading make it an ideal packing material for adsorption plasma catalytic removal of VOCs. This work highlights the use of zeolites for cyclic adsorption plasma catalysis in order to reduce the energy cost to decompose per VOC molecule and to regenerate zeolites via plasma.
Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss
Authors: Singleton Quante , Vaibhav Kumar , Braun Molly , Patel Chandani , Khayrullin Andrew , Mendhe Bharati , Lee Byung R. , Kolhe Ravindra , Kaiser Helen , Awad Mohamed E. , Fariyike Tunde , Elsayed Ranya , Elsalanty Mohammed , Isales Carlos M. , Liu Yutao , Hamrick Mark W. , Dhandapani Krishnan M. , Fulzele Sadanand
Published: January 2019

Traumatic brain injury (TBI) is a major source of worldwide morbidity and mortality. Patients suffering from TBI exhibit a higher susceptibility to bone loss and an increased rate of bone fractures; however, the underlying mechanisms remain poorly defined. Herein, we observed significantly lower bone quality and elevated levels of inflammation in bone and bone marrow niche after controlled cortical impact-induced TBI in in vivo CD-1 mice. Further, we identified dysregulated NF-κB signaling, an established mediator of osteoclast differentiation and bone loss, within the bone marrow niche of TBI mice. Ex vivo studies revealed increased osteoclast differentiation in bone marrow-derived cells from TBI mice, as compared to sham injured mice. We also found bone marrow derived extracellular vesicles (EVs) from TBI mice enhanced the colony forming ability and osteoclast differentiation efficacy and activated NF-κB signaling genes in bone marrow-derived cells. Additionally, we showed that miRNA-1224 up-regulated in bone marrow-derived EVs cargo of TBI. Taken together, we provide evidence that TBI-induced inflammatory stress on bone and the bone marrow niche may activate NF-κB leading to accelerated bone loss. Targeted inhibition of these signaling pathways may reverse TBI-induced bone loss and reduce fracture rates.
Yeast to Study Human Purine Metabolism Diseases
Authors: Daignan-Fornier Bertrand , Pinson Benoît
Published: January 2019

Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly understood and simple model organisms, such as yeast, have proved valuable to provide a more comprehensive view of the metabolic consequences caused by the identified mutations. In this review, we present results obtained with the yeast Saccharomyces cerevisiae to exemplify how a eukaryotic unicellular organism can offer highly relevant information for identifying the molecular basis of complex human diseases. Overall, purine metabolism illustrates a remarkable conservation of genes, functions and phenotypes between humans and yeast.
The Power of Massage in Children with Cancer—How Can We Do Effective Research?
Authors: Jacobs Shana , Mowbray Catriona
Published: January 2019

Children with cancer experience multiple troubling symptoms. Massage offers a safe, non-pharmacological approach to address these symptoms. Numerous studies of massage in children and adults with cancer have been performed, yet most are unable to demonstrate significant benefit. This review aims to summarize what we know about the role of massage and sets goals and challenges for future massage research. This paper descriptively reviews the existing literature available in PubMed (both prior reviews and select papers) and the holes in prior research studies. Prior research on massage has been limited by small sample size/insufficient power, inappropriate outcome measures or timing, heterogeneous patient populations, inconsistent intervention techniques, and other design flaws. Based on the findings and limitations of previous work, numerous suggestions are made for future studies to increase the potency of findings, including thoughts about appropriate dosing, control groups, type of intervention, outcome measures, patient selection, feasibility, and statistics.
Rapid Electrodeposition of Fe–Ni Alloy Foils from Chloride Baths Containing Trivalent Iron Ions
Authors: Su Changwei , Zhao Linfu , Tian Liang , Wen Bixia , Xiang Mingwu , Bai Wei , Guo Junming
Published: January 2019

This work presents the rapid electrodeposition of Fe–Ni alloy foils from chloride baths containing trivalent iron ions at a low pH (<0.0). The effect of the concentration of Ni2+ ions on the content, surface morphology, crystal structure, and tensile property of Fe–Ni alloys is studied in detail. The results show that the co-deposition of Fe and Ni is controlled by the adsorption of divalent nickel species at low current density and the ionic diffusion at high current density. The current density of preparing smooth and flexible Fe–Ni alloy foils is increased by increasing the concentration of Ni2+ ions, consequently the deposition rate of Fe–Ni alloy foils is increased. For example, at 0.6 M Ni2+ ions, the current density can be applied at 50 A·dm−2, along with a high deposition rate of ~288 μm·h−1.
A Novel Algorithm of Constructing Highly Nonlinear S-p-boxes
Authors: Naseer Yasir , Shah Tariq , Shah Dawood , Hussain Sadam
Published: January 2019

The role of substitution boxes is very important in block ciphers. Substitution boxes are utilized to create confusion in the cryptosystem. However, to create both confusion and diffusion in any cryptosystem p-boxes and chaos base substitution boxes are designed. In this work, a simple method is presented that serves both ways. This method is based on composition of the action of symmetric group on Galois field and inversion map. This construction method provides a large number of highly non-linear substitution permutation boxes having the property of confusion as well as diffusion. These substitution permutation boxes have all the cryptography properties. Their utilization in the image encryption application is measured by majority logic criterion. We named these newly designed substitution boxes (S-boxes) as substitution permutation boxes (S-p-boxes), because they serve as both substitution boxes (S-boxes) as well as permutation boxes (p-boxes).
Spatio-temporal Investigations of the Incomplete Spin Transition in a Single Crystal of [Fe(2-pytrz)2{Pt(CN)4}]·3H2O: Experiment and Theory
Authors: Fourati Houcem , Bouchez Guillaume , Paez-Espejo Miguel , Triki Smail , Boukheddaden Kamel
Published: January 2019

Optical microscopy technique is used to investigate the thermal and the spatio-temporal properties of the spin-crossover single crystal [Fe(2-pytrz) 2 {Pt(CN) 4 }]·3H 2 O, which exhibits a first-order spin transition from a full high-spin (HS) state at high temperature to an intermediate, high-spin low-spin (HS-LS) state, below 153 K, where only one of the two crystallographic Fe(II) centers switches from the HS to HS-LS state. In comparison with crystals undergoing a complete spin transition, the present transformation involves smaller volume changes at the transition, which helps to preserving the crystal’s integrity. By analyzing the spatio-temporal properties of this spin transition, we evidenced a direct correlation between the orientation and shape of HS/HS-LS domain wall with the crystal’s shape. Thanks to the small volume change accompanying this spin transition, the analysis of the experimental data by an anisotropic reaction-diffusion model becomes very relevant and leads to an excellent agreement with the experimental observations.
Investigation of Piezoelectric Ringing Frequency Response of Beta Barium Borate Crystals
Authors: Sinkevicius Giedrius , Baskys Algirdas
Published: January 2019

The piezoelectric ringing phenomenon in Pockels cells based on the beta barium borate crystals was analyzed in this work. The investigation results show that piezoelectric ringing is caused by multiple high voltage pulses with a frequency in the range from 10 kHz up to 1 MHz. Experimental investigation of frequency response and Discrete Fourier transformation was used for analysis. The method of piezoelectric ringing investigation based on the analysis of difference of real and simulated optical signals spectrums was proposed. The investigations were performed for crystals with 3 × 3 × 25 mm, 4 × 4 × 25 mm and 4 × 4 × 20 mm dimensions. It was estimated that piezoelectric ringing in the beta barium borate crystal with dimensions of 3 × 3 mm × 25 mm occurred at the 150, 205, 445, 600 and 750 kHz frequencies of high voltage pulses.
Tuning the Size, Shape and Density of γ′-GayFe4−yN Nanocrystals Embedded in GaN
Authors: Navarro-Quezada Andrea , Devillers Thibaut , Li Tian , Bonanni Alberta
Published: January 2019

Phase-separated semiconductor systems hosting magnetic nanocrystal (NCs) are attracting increasing attention, due to their potential as spintronic elements for the next generation of devices. Owing to their morphology- and stoichiometry-dependent magnetic response, self-assembled γ ’-Ga y Fe 4 − y N NCs embedded in a Fe δ -doped GaN matrix, are particularly versatile. It is studied and reported here, how the tuning of relevant growth parameters during the metalorganic vapour phase epitaxy process affects the crystalline arrangement, size, and shape of these self-assembled nanostructures. In particular, it is found that the Ga-flow provided during the δ -doping, determines the amount of Fe incorporated into the layers and the spatial density of the NCs. Moreover, the in-plane dimensions of the NCs can also be controlled via the Ga-flow, conditioning the aspect-ratio of the embedded nanostructures. These findings are pivotal for the design of nanocrystal arrays with on-demand size and shape, essential requirements for the implementation into functional devices.
Data-Driven Studies of Li-Ion-Battery Materials
Authors: Kauwe Steven K. , Rhone Trevor David , Sparks Taylor D.
Published: January 2019

Batteries are a critical component of modern society. The growing demand for new battery materials—coupled with a historically long materials development time—highlights the need for advances in battery materials development. Understanding battery systems has been frustratingly slow for the materials science community. In particular, the discovery of more abundant battery materials has been difficult. In this paper, we describe how machine learning tools can be exploited to predict the properties of battery materials. In particular, we report the challenges associated with a data-driven investigation of battery systems. Using a dataset of cathode materials and various statistical models, we predicted the specific discharge capacity at 25 cycles. We discuss the present limitations of this approach and propose a paradigm shift in the materials research process that would better allow data-driven approaches to excel in aiding the discovery of battery materials.
Cost-Efficient and Easy to Perform PCR-Based Assay to Identify Met Exon 14 Skipping in Formalin-Fixed Paraffin-Embedded (FFPE) Non-Small Cell Lung Cancer (NSCLC) Samples
Authors: O’Brien Odharnaith , Wright Mark C. , O’Brien Cathal , Geoghegan Orla , Leonard Niamh , Nicholson Siobhan , Cuffe Sinéad , Fabre Aurelie , Jochum Wolfram , Joerger Markus , Gray Steven G. , Finn Stephen P.
Published: January 2019

MET is a receptor tyrosine kinase (RTK) that plays important roles in carcinogenesis. Despite being frequently overexpressed in cancer, clinical responses to targeting this receptor have been limited. Recently novel splicing mutations involving the loss of exon 14 (called METex14 skipping) have emerged as potential biomarkers to predict for responsiveness to targeted therapies with Met inhibitors in non-small cell lung cancer (NSCLC). Currently, the diverse genomic alterations responsible for METex14 skipping pose a challenge for routine clinical diagnostic testing. In this report, we examine three different methodologies to detect METex14 and assess their potential utility for use as a diagnostic assay for both the identification of METex14 and intra-tumoural distribution in NSCLC.
A Psychometric Re-Examination of the Science Teaching Efficacy and Beliefs Instrument (STEBI) in a Canadian Context
Authors: Moslemi Neda , Mousavi Amin
Published: January 2019

A teacher’s self-efficacy has been found to be one of the most important factors contributing to a successful teaching–learning outcome for both the teacher and the students. Numerous studies have shown that there is a relationship between students’ self-efficacy, students’ academic achievement, teacher burnout and a teacher’s sense of self-efficacy. In this study, the psychometric properties of the Science Teaching Efficacy and Beliefs Instrument (STEBI) by Riggs and Enochs (1990) were re-examined in a Canadian context utilizing data of 1630 teachers from the Pan-Canadian Assessment Program (PCAP) in 2013. Exploratory factor analysis (EFA) and its associated methods were used to investigate the factorial structure of the STEBI, and Cronbach’s alpha was calculated as a measure of reliability. The results showed adequacy of a two-factor solution and similar overall patterns of factor loadings across orthogonal and oblique rotations. In terms of reliability analysis, both factors had reliability coefficients lower than the original scale. The implications of these findings and the future directions for research are discussed.
A Simple Indoor Localization Methodology for Fast Building Classification Models Based on Fingerprints
Authors: Sánchez-Rodríguez David , Alonso-González Itziar , Ley-Bosch Carlos , Quintana-Suárez Miguel A.
Published: January 2019

Indoor localization has received tremendous attention in the last two decades due to location-aware services being highly demanded. Wireless networks have been suggested to solve this problem in many research works, and efficient algorithms have been developed with precise location and high accuracy. Nevertheless, those approaches often have high computational and high energy consumption. Hence, in temporary environments, such as emergency situations, where a fast deployment of an indoor localization system is required, those methods are not appropriate. In this manuscript, a methodology for fast building of an indoor localization system is proposed. For that purpose, a reduction of the data dimensionality is achieved by applying data fusion and feature transformation, which allow us to reduce the computational cost of the classifier training phase. In order to validate the methodology, three different datasets were used: two of them are public datasets based mainly on Received Signal Strength (RSS) from different Wi-Fi access point, and the third is a set of RSS values gathered from the LED lamps in a Visible Light Communication (VLC) network. The simulation results show that the proposed methodology considerably amends the overall computational performance and provides an acceptable location estimation error.
The Spatial Spillover Effects of Environmental Regulation on China’s Industrial Green Growth Performance
Authors: Wang Xiping , Li Moyang
Published: January 2019

This study investigated the spatial spillover effects of environmental regulation (ER) on industrial green growth performance (IGGP) in China. Firstly, a parametric stochastic frontier analysis (SFA) was estimated to measure IGGP using the data of China’s 30 provincial industry sectors during 2000–2014. Then, considering the space–time characteristics in IGGP, the spatial spillover effects of three types of ER, namely, administrative environmental regulation (AER), market-based environmental regulation (MER), and voluntary environmental regulation (VER), on IGGP was examined by employing spatial Durbin model (SDM). The main findings are: (1) the IGGP is low but shows a trend of continuous improvement and there is a significant disparity and spatial autocorrelations amongst regions; (2) the spillover effects of the three types of ER are different, specifically, the spillover effects of AER are significant negative, while the effects of MER and VER are both significant positive. The difference between the latter two is that the positive spillover effect of MER on IGGP is so large to outperform the negative direct effect, while the effect of VER is very minor. Based on these findings, relevant policy suggestions are presented to balance industrial economic and environmental protection in order to promote IGGP.
Communication and Household Adoption of Heating Products in Hungary
Authors: Munkacsi Noemi , Mahapatra Krushna
Published: January 2019

Existing studies of heating products have analyzed the adoption of energy-efficient heating technologies from diverse micro and macroeconomic aspects, such as diffusion of innovation, willingness to pay, business models, energy pricing, etc., but the analysis from a marketing management approach based on end customer insight is still lacking. Understanding the decision-making process of end customers, and the influence of social environment at the diverse stages of the purchase process leads to a focused market strategy, thereby contributes toward overcoming the multi-level segmentation challenge faced by the manufacturers of heating products. In this context, a two-step exploratory research was conducted in December 2013 with end customers of the residential heat market in Hungary. The end customers were found to be active decision-makers engaged in deliberate planning in the purchase of heating products. They start searching for information by turning mainly to online information sources and they actively integrate their social network in all stages of the decision-making process, which means that the role of the installer is relatively less influential along the whole purchasing process. Identified influencing communication channels at the diverse stages of the purchase process may support manufacturers to develop a user-centric marketing strategy by optimizing the communication instruments in their marketing mix by, for instance, including direct end customer communication via online channels and by de-emphasizing offline communication channels.
Spatial Distributive Differences in Residents’ Perceptions of Tourism Impacts in Support for Sustainable Tourism Development—Lu-Kang Destination Case
Authors: Lin Chung-Hsien , Wang Wei-Ching , Yeh Yuan-I Eric
Published: January 2019

Few empirical studies on the effect of tourism impacts on residents’ support for tourism development have linked an environmental justice perspective with sustainable tourism. This study aims to explore spatial distributive differences in residents’ perceptions of tourism impacts to understand their support for sustainable tourism development. A total of 1057 residents of the Lu-Kang destination in Taiwan were surveyed using an on-site questionnaire. Employing the kernel density method and the local K function for spatial point analysis, the results indicated that spatial clustering of residents’ perceptions of both positive and negative tourism impacts occurred in the specific locations. Further, high household income, high education, and more personal benefits from tourism promoted the formation of localized spatial clusters where residents had positive perceptions of tourism impacts which, in turn, led to a high level of support for tourism development. Conversely, low income, low education, and less personal benefits from tourism cultivated the development of spatial clusters with negative perceptions of tourism impacts which, in turn, caused a low level of support for tourism development. The implications for sustainable tourism planning and strategies are discussed.
Kinetic Parameters of Saccharomyces cerevisiae Alcohols Production Using Nepenthes mirabilis Pod Digestive Fluids-Mixed Agro-Waste Hydrolysates
Authors: Dlangamandla Nkosikho , Ntwampe Seteno K. O. , Angadam Justine O. , Chidi Boredi S. , Mewa-Ngongang Maxwell
Published: January 2019

In this study, microbial growth kinetics and modeling of alcohols production using Saccharomyces cerevisiae were evaluated using different hydrolysates in a single pot (batch) system. Mixed agro-waste hydrolysates from different pre-treatment methods, i.e., N. mirabilis/CP and HWP/DAP/CP, were used as the sole nutrient source in the fermentations used to produce the alcohols of interest. The maximum Saccharomyces cerevisiae concentration of 1.47 CFU/mL (×1010) was observed with HWP/DAP/CP hydrolysates, with a relative difference of 21.1% when compared to the N. mirabilis/CP cultures; the product yield based on biomass generation was relatively (20.2%) higher for the N. mirabilis/CP cultures. For the total residual phenolic compounds (TRPCs) generation, a relative difference (24.6%) between N. mirabilis/CP and HWP/DAP/CP pre-treatment systems was observed, suggesting that N. mirabilis/CP generates lower inhibition by-products. This was further evidenced by the lowest substrate utilization rate (3.3 × 10−4 g/(L·h)) for the N. mirabilis/CP cultures while achieving relatively similar product formation rates to those observed for the HWP/DAP/CP. A better correlation (R2 = 0.94) was obtained when predicting substrate utilization for the N. mirabilis/CP cultures. Generally, the pre-treatment of mixed agro-waste using N. mirabilis/CP seemed appropriate for producing hydrolysates which Saccharomyces cerevisiae can effectively use for alcohol production in the biorefinery industry.
Progress in Multi-Wavelength and Multi-Messenger Observations of Blazars and Theoretical Challenges
Authors: Böttcher Markus
Published: January 2019

This review provides an overview of recent advances in multi-wavelength and multi-messenger observations of blazars, the current status of theoretical models for blazar emission, and prospects for future facilities. The discussion of observational results will focus on advances made possible through the Fermi Gamma-Ray Space Telescope and ground-based gamma-ray observatories (H.E.S.S., MAGIC, VERITAS), as well as the recent first evidence for a blazar being a source of IceCube neutrinos. The main focus of this review will be the discussion of our current theoretical understanding of blazar multi-wavelength and multi-messenger emission, in the spectral, time, and polarization domains. Future progress will be expected in particular through the development of the first X-ray polarimeter, IXPE, and the installation of the Cherenkov Telescope Array (CTA), both expected to become operational in the early to mid 2020s.
Geotourism
Authors: Ólafsdóttir Rannveig
Published: January 2019

Geotourism is one of the newest concepts within the field of tourism, and primarily focuses on promoting geological and geomorphological features in landscapes as tourist attractions. This new niche market segment within tourism is based on the conservation of geoheritage and geodiversity through appropriate sustainability measures and management. Geotourism is, however, a broad concept which encompasses many aspects of a range of tourism activities, such as transport, accommodation, destination amenities, recreation, planning, and management. A testament to the rapid growth of geotourism worldwide is the expansion of membership of the UNESCO Global Geoparks Network, from 20 geoparks when it was founded in 2004 to 140 in 2018. Concurrent with the growth of geotourism, there has been an explosion in the number of scientific publications on issues related to the subject over the past few years. To date, the major focus of these publications has been on geotourism as an economic driver with respect to rural development. This special issue of Geotourism presents a collection of 11 scientific contributions that underpin the intimate connection between geotourism and its geological resources, while at the same time highlighting the broad scope of geotourism. These contributions increase our understanding of how geotourism has evolved over time, as well as its setting out what challenges it faces in the future.
Relationship between Winter Snow Cover Dynamics, Climate and Spring Grassland Vegetation Phenology in Inner Mongolia, China
Authors: Qiao Dejing , Wang Nianqin
Published: January 2019

The onset date of spring phenology (SOS) is regarded as a key parameter for understanding and modeling vegetation–climate interactions. Inner Mongolia has a typical temperate grassland vegetation ecosystem, and has a rich snow cover during winter. Due to climate change, the winter snow cover has undergone significant changes that will inevitably affect the vegetation growth. Therefore, improving our ability to accurately describe the responses of spring grassland vegetation phenology to winter snow cover dynamics would enhance our understanding of changes in terrestrial ecosystems due to their responses to climate changes. In this study, we quantified the spatial-temporal change of SOS by using the Advanced Very High Resolution Radiometer (AVHRR) derived Normalized Difference Vegetation Index (NDVI) from 1982 to 2015, and explored the relationships between winter snow cover, climate, and SOS across different grassland vegetation types. The results showed that the SOS advanced significantly at a rate of 0.3 days/year. Winter snow cover dynamics presented a significant positive correlation with the SOS, except for the start date of snow cover. Moreover, the relationship with the increasing temperature and precipitation showed a significant negative correlation, except that increasing Tmax (maximum air temperature) and Tavg (average air temperature) would lead a delay in SOS for desert steppe ecosystems. Sunshine hours and relative humidity showed a weaker correlation.
GEOBIA at the Terapixel Scale: Toward Efficient Mapping of Small Woody Features from Heterogeneous VHR Scenes
Authors: Merciol François , Faucqueur Loïc , Damodaran Bharath Bhushan , Rémy Pierre-Yves , Desclée Baudouin , Dazin Fabrice , Lefèvre Sébastien , Masse Antoine , Sannier Christophe
Published: January 2019

Land cover mapping has benefited a lot from the introduction of the Geographic Object-Based Image Analysis (GEOBIA) paradigm, that allowed to move from a pixelwise analysis to a processing of elements with richer semantic content, namely objects or regions. However, this paradigm requires to define an appropriate scale, that can be challenging in a large-area study where a wide range of landscapes can be observed. We propose here to conduct the multiscale analysis based on hierarchical representations, from which features known as differential attribute profiles are derived over each single pixel. Efficient and scalable algorithms for construction and analysis of such representations, together with an optimized usage of the random forest classifier, provide us with a semi-supervised framework in which a user can drive mapping of elements such as Small Woody Features at a very large area. Indeed, the proposed open-source methodology has been successfully used to derive a part of the High Resolution Layers (HRL) product of the Copernicus Land Monitoring service, thus showing how the GEOBIA framework can be used in a big data scenario made of more than 38,000 Very High Resolution (VHR) satellite images representing more than 120 TB of data.
Expressing Double-Stranded RNAs of Insect Hormone-Related Genes Enhances Baculovirus Insecticidal Activity
Authors: Liu Zheming , Wang Xiaofang , Dai Yan , Wei Xiaoli , Ni Mi , Zhang Lei , Zhu Zhen
Published: January 2019

Baculoviruses have already been used for insect pest control, but the slow killing speed limits their further promotion and application. Here we provide a strategy for improving baculovirus insecticidal activity using Helicoverpa armigera nucleopolyhedrovirus (HearNPV) to express double-stranded RNAs (dsRNAs) targeting cotton bollworm (Helicoverpa armigera) juvenile hormone (JH)-related genes. Droplet-feeding bioassays show that the 50% lethal concentration (LC50) values of recombinant baculoviruses expressing the dsRNA of JH acid methyl transferase gene (HaJHAMT) and the JH acid binding protein gene (HaJHBP) were 1.24 × 104 polyhedral inclusion bodies (PIB)/mL and 2.26 × 104 PIB/mL, respectively. Both were much lower than the control value (8.12 × 104 PIB/mL). Meanwhile, the LT50 of recombinant baculovirus expressing dsRNA of HaJHBP was only 54.2% of the control value, which means that larval death was accelerated. Furthermore, the mRNA level of target genes was reduced in recombinant baculovirus-treated cotton bollworm larvae. Transcription of several key genes involved in hormone signaling pathways—for example, ecdysone receptor gene (HaEcR)—was also altered. This study establishes a new strategy for pest management by interfering with insect hormone-related gene expression via baculoviruses, and the engineered baculoviruses have great potential application in cotton production.
Molecular Theranostic Agents for Photodynamic Therapy (PDT) and Magnetic Resonance Imaging (MRI)
Authors: Jenni Sébastien , Sour Angélique
Published: January 2019

Magnetic resonance imaging (MRI) is a powerful non-invasive diagnostic tool that can provide important insights for medical treatment monitoring and optimization. Photodynamic therapy (PDT), a minimally invasive treatment for various types of tumors, is drawing increasing interest thanks to its temporal and spatial selectivity. The combination of MRI and PDT offers real-time monitoring of treatment and can give significant information for drug-uptake and light-delivery parameters optimization. In this review we will give an overview of molecular theranostic agents that have been designed for their potential application in MRI and PDT.
Thirty-Day Postoperative Outcomes Following Sugammadex Use in Colorectal Surgery Patients: Retrospective Study
Authors: Chae Yun , Joe Han , Oh Juyeon , Lee Eunyoung , Yi In
Published: January 2019

Purpose: Sugammadex rapidly reverses muscle relaxation compared to acetylcholinesterase inhibitors. The long-term outcomes of sugammadex, however, are not well known. We compared 30-day postoperative outcomes following sugammadex and acetylcholinesterase inhibitor use in colorectal surgery patients. Patients and methods: Colorectal surgical patients older than 21 were included in this retrospective study, and were dichotomized according to use of reversal agents, sugammadex (group S), and acetylcholinesterase inhibitor (group A). We assessed 30-day postoperative outcomes, including total length of hospital stay, length of postoperative hospital stay, readmission rate, and delayed discharge rate. Additional parameters included postanesthetic care unit stay time, time to first successful oral intake, unforeseen intensive care unit (ICU) admission rate, postoperative pulmonary complications, and mortality. Results: Among a total of 585 patients, 157 patients remained in each group after propensity score matching. Total length of hospital stay, length of postoperative hospital stay, and readmission rates did not differ between the two groups, while the incidence of delayed discharge was significantly lower in group S (23 (15%) vs. 40 (25%), p = 0.017). Other outcomes did not differ between the two groups. Conclusion: We found no difference in 30-day postoperative outcomes following sugammadex and acetylcholinesterase inhibitor use. The only difference between these treatments was the associated incidence of delayed discharge, which was lower in group S.