bluuebunny/crossref_metadata_2025 huggingface dataset:
Translation and cross-cultural adaptation of the Nepali version of Sexual Interest and Satisfaction Scale (SIS): a cross-sectional study
Authors: Nepal Govinda Mani , Maharjan Sonu , Sherpa Nima
Published: November 2024

Background and objective

Individuals with Spinal Cord Injury (SCI) rank regaining sexual function as their top priority. Sexual dissatisfaction often leads to low self-esteem, reduced intimacy, and relationship difficulties and hence forms an essential part of the rehabilitation process. In Nepal, where people generally hold fairly traditional views about sex and sexual health, a sexual outcome measure that is culturally sensitive is a must for addressing sexual problems. No study has yet been carried out to investigate the impact of SCI on sexual attitudes and satisfaction in Nepal. Therefore, this study aims to translate and cross-culturally adapt the Sexual Interest and Satisfaction Scale (SIS) in the Nepali language.

Methods

(1) Forward translation: Three translators translated the English version of SIS into Nepali. (2) Synthesis: The three translated versions were synthesized into a draft version. (3) Expert committee review: The expert committee meetings were held to reach a consensus for a sensible and applicable pre-final version of SIS. (4) Pre-test: The pre-final version of SIS was tested on 25 individuals with SCI. Their opinions and comprehension were documented for each question, and subsequent modifications were made to form the final version of Nepali SIS (SIS-NP). The internal consistency of SIS-NP was calculated using Cronbach’s alpha.

Results

The translation and cross-cultural adaptation segregated the questions into two divisions: first, which could be answered by everyone irrespective of their sexual partner status, and second, which could only be answered by those with a sexual partner. No changes were made to the original questions; however, essential clarifications and definitions were added. A total of 66 individuals with SCI participated to evaluate internal consistency with a median duration of injury of 9.5 years (IQR = 9.25). Unmarried participants accounted for 40% (n = 27). Internal consistency was found to be 0.74.

Conclusion

SIS was translated to Nepali, adapting standard recommended guidelines. SIS-NP demonstrated adequate internal consistency to be used in SCI.
Inter- and intra-tumoral heterogeneity on [68Ga]Ga-DOTA-TATE/[68Ga]Ga-DOTA-TOC PET/CT predicts response to [177Lu]Lu-DOTA-TATE PRRT in neuroendocrine tumor patients
Authors: Gadens Zamboni Camila , Dundar Ayca , Jain Sanchay , Kruzer Marc , Loeffler Bradley T. , Graves Stephen A. , Pollard Janet H. , Mott Sarah L. , Dillon Joseph S. , Graham Michael M. , Menda Yusuf , Shariftabrizi Ahmad
Published: November 2024

Background

Indices of tumor heterogeneity on somatostatin receptor PET/CT scans may potentially serve as predictive biomarkers of treatment efficacy in neuroendocrine tumor (NET) patients undergoing [177Lu]Lu-DOTA-TATE PRRT.

Methods

NET patients who underwent [177Lu]Lu-DOTA-TATE therapy at the University of Iowa from August 2018 to February 2021 were retrospectively evaluated. Radiomic features on the pre-PRRT somatostatin receptor PET/CT were evaluated using a custom MIM Software® LesionID workflow. Conventional PET/CT metrics of tumor burden, such as somatostatin receptor expression and tumor volume, were calculated in addition to the indices of tumor heterogeneity for each lesion (intra-lesional) and then summarized across all lesions throughout the body (inter-lesional). Endpoints included post-PRRT 24-month time to progression (TTP) and overall survival (OS). Cox regression models were used to assess the predictive ability of the imaging factors on post-PRRT 24-month TTP and OS. LASSO-penalized Cox regression was used to build a multivariable model for each outcome.

Results

Eighty patients with a mean age of 65.1 years were included, with most (71.3%) completing 4 cycles of PRRT. Median TTP was 19.1 months, and OS at 60 months was 50%. A large degree of variability between patients was evidenced for imaging features related to somatostatin receptor expression. On multivariable analysis, total receptor expression and mean liver-corrected SUVmean were selected for 24-month TTP. The model was not able to significantly predict progression (C-statistic = 0.58, 95% CI 0.50–0.62). Total receptor expression and mean skewness were selected for OS. The resulting model was able to significantly predict death (C-statistic = 0.62, 95% CI 0.53–0.67), but the predictive ability was limited, as evidenced by the low C-statistic.

Conclusions

Our exploratory analysis provides preliminary results showing that imaging indices of inter- and intra-tumor heterogeneity from pretreatment PET/CT images may potentially predict treatment efficacy in NET patients undergoing [177Lu]Lu-DOTA-TATE therapy. However, prospective evaluation in a larger cohort is needed to further assess whether a comprehensive characterization of tumor heterogeneity within a patient can help guide treatment decisions.
Lifestyle discussions facilitate self-management in RA: a qualitative study of patients’ perceptions
Authors: Drake af Hagelsrum Klara , Larsson Ingrid , Bremander Ann , Einarsson Jon T. , Lindqvist Elisabet , Mogard Elisabeth
Published: November 2024

Background

Healthy lifestyle habits (regular physical activity, a healthy diet, no smoking and non-hazardous alcohol consumption) alongside pharmacological treatment can lower the risk of cardiovascular diseases and improve symptoms and quality of life in patients with rheumatoid arthritis (RA). Therefore, healthcare professionals in rheumatology care are urged to discuss lifestyle habits with all patients. The aim of this study was to explore patients’ perceptions of lifestyle discussions in early rheumatology care.

Methods

Individual interviews were conducted with 20 patients with RA, 14 women and six men, aged 23 to 77 years, and with a mean disease duration of 2.4 years. All lifestyle discussions were performed during the first year with RA. A qualitative content analysis was performed.

Results

An overarching theme emerged, exploring how patients with RA perceived lifestyle discussions as facilitating self-management. Three categories illustrated this: (1) the usefulness of lifestyle discussions depended on the individual patient’s preferences and prioritization for lifestyle support; (2) the design of lifestyle discussions should be based on a person-centred approach, incorporating personalized lifestyle information and providing structured and recurrent support; (3) the outcomes of lifestyle discussions should contribute to enhanced knowledge and motivation for making healthy lifestyle changes.

Conclusion

Lifestyle discussions in early rheumatology care should, according to patients with RA, be based on a person-centred approach, be tailored to each patient’s preferences and needs, and have outcomes focusing on patient support for healthy lifestyle changes, all essential elements to facilitate self-management. The present findings can be used to guide the development and implementation of more person-centred lifestyle approaches targeted to facilitate lifestyle changes and benefit cardiovascular disease risk management in early rheumatology care.
A case of double aneuploidy of Down and Klinefelter syndrome in an Indian infant: a detailed case report
Authors: Patel Sunny Kumar Jignesh Kumar , Sheikh Shagufa , Banerjee Birendranath
Published: November 2024

Background

A variation in the number of chromosomes can lead to chromosomal disorders. These chromosomal aberrations might be related to autosomes or sex chromosomes. The most common chromosomal aberrations that are sex-linked and autosomal are Klinefelter syndrome and Down syndrome, respectively. However, the worldwide occurrence of double chromosomal aneuploidy in a single individual is relatively exceptional event and random meiotic nondisjunction events result in double aneuploidy, which causes trisomy of two distinct chromosomes. The clinical manifestations vary depending on whether aneuploidy is dominant or an amalgam of both. Moreover, double aneuploidy including autosome and sex chromosome is not often documented. In this paper, we document a case of Down–Klinefelter double aneuploidy syndrome in an Indian infant hospitalized to the neonatal care unit.

Case presentation

A full-term 9-month-old male infant born to a 36-year-old female with classical clinical signs of Down syndrome like epicanthus, a depressed nasal bridge, a flat face, small ears, an open mouth, thick lower lip vermilion, a protruding tongue, and a short neck was referred for cytogenetic examination, revealing a rare karyotype of 48, XXY, + 21.

Conclusion

Down–Klinefelter syndrome is a rare chromosomal anomaly with unique characteristics, often displaying only Down syndrome-like traits at birth. Early diagnosis can be challenging due to the lack of noticeable symptoms until puberty. Early cytogenetic investigation can detect double aneuploidy, improving the affected person's quality of life and educating family members about potential medical and psychosocial difficulties.
Pai syndrome associated with vomer agenesis: case report with review of literature
Authors: Nibhanupudi Kamala Manogna , Sankaravadivel Saradha Preethi , Padmanaban Elamparidhi , Amirthalingam Umamageswari , Varadane Avinesh , Balavaitheeswar R. L.
Published: November 2024

Background

Frontonasal Dysplasia (FND) is an uncommon developmental defect affecting the midface, leading to abnormal facial development. Pai Syndrome is a part of the frontonasal dysplasia spectrum, is typically marked by median cleft lip, cutaneous polyps, and midline central nervous system lipomas. Pai Syndrome is also associated with various intracranial abnormalities. This is the first documented case of Pai Syndrome in a female patient with concurrent vomer agenesis.

Case presentation

A 17-year-old female with persistent nasal obstruction and a history of median cleft lip and palate surgery was found to have deviated nasal septum and nasal mass. CT revealed polypoidal thickening in the left maxillary sinus, an incomplete nasal septum with a defect, and lipoma in the nasal septum. There was also pericallosal lipoma with bracket calcification and partial agenesis of the corpus callosum. Ophthalmologic evaluation showed hypertelorism. The diagnosis was consistent with frontonasal dysplasia, potentially Pai Syndrome or a variant.

Conclusion

The presence of midline nasal lipomas or masses should raise concerns about Pai Syndrome and other frontonasal dysplasia. Additional imaging is necessary to detect associated congenital abnormalities, which aids in accurately diagnosing Pai Syndrome and planning surgical treatments.
Cardiac myxomas: a review of current treatment approaches and emerging molecular therapies
Authors: Ashinze Patrick , Banerjee Suvam , Egbunu Emmanuel , Salawu Wuraola , Idris-Agbabiaka Abdullaah , Obafemi Eniola , Olajuwon Tolulope Joseph , Chukwu Bethrand , Aremu Sikiru Ademola , David Olafisoye-Oragbade Oluwatosin , Alausa Hamdallah Modupe , Iwaloye Folayemi Abiodun
Published: November 2024

Background

Cardiac myxomas are the most common primary cardiac tumors, predominantly located in the left atrium. These benign tumors can obstruct blood flow, cause embolization, or produce systemic symptoms like fever. Diagnostic tools such as echocardiography play a critical role in their identification, while surgical resection remains the primary curative treatment. Although recurrence is rare, it occurs more frequently in patients with genetic predispositions, such as the Carney complex. The risk of life-threatening complications such as embolism and sudden death necessitates prompt diagnosis and management. Despite the success of surgical treatment, recent advances have introduced minimally invasive techniques and novel molecular therapies, particularly for recurrent cases.

Main body

The epidemiology of cardiac myxomas highlights their rarity, with an incidence of 0.5–1 per million individuals annually. They are classified based on location, morphology, and whether they are sporadic or syndromic. Histologically, they originate from multipotent mesenchymal cells and present as gelatinous or solid masses. The genetic implicants, especially in familial cases, involve certain gene mutations, disrupting signaling pathways and leading to tumorigenesis. Diagnosis primarily relies on imaging, with transthoracic echocardiography being the first-line modality. Surgical resection, typically via median sternotomy, remains the gold standard treatment with a low recurrence rate. However, emerging molecular therapies, including gene editing, epigenetic interventions, stem cell therapy, and immunotherapy, offer promising avenues for managing complex or recurrent cases even though they are mostly in conceptual and preclinical phases. These molecular approaches target specific genetic and signaling pathways involved in myxoma formation and recurrence, and though they remain in experimental stages, the advent of gene therapy in oncology makes them the next best choice to watch out for.

Conclusions

While surgical resection remains curative in most cases, recurrence, particularly in familial syndromes, requires vigilant monitoring and innovative treatments. Emerging molecular therapies show potential in offering personalized treatment options, although they are still inchoate. Further research is needed to improve delivery systems and minimize the challenges associated with these therapies, paving the way for more effective management strategies.
Rational design of cobalt oxide nanocubes arrays on Ni foam as durable and robust electrocatalyst for urea electro-oxidation
Authors: Ismail Mona M. , Farghali Ahmed A. , El-Deen Ahmed G.
Published: November 2024

Background

Cobalt oxide (Co3O4) is a promising electrocatalyst for efficient urea electro-oxidation, tackling power consumption and environmental challenges. The controllable design of free-standing Co3O4 nanostructures grown on Ni foam (NF) substrates was achieved using a green and facile hydrothermal approach. Different reducing agents were applied to synthesize various morphological structures of Co3O4, including nanoparticles, nanowires, and nanocubes (NCs) morphologies.

Results

The as-fabricated electrodes were investigated as electrocatalysts for enhanced urea electro-oxidation. Because of its 3D nanostructure with minimal agglomeration and a large interfacial surface area with adequate electroactive sites, the Co3O4 NCs/NF had the best energy conversion efficiency of any electrode toward the urea oxidation process. These distinctive features facilitated the electron and urea routes used in the urea electro-oxidation process. It had a low-onset potential of 194.2 mV (vs. Hg/HgO) and a current density of 90.2 mA cm−2 in a 1 M KOH electrolyte. The electrocatalyst demonstrated excellent anodic activity for urea electro-oxidation with an onset potential of 196.7 mV and a current density of 256.1 mA cm−2 in 1 M KOH + 0.3 M urea concentration. Furthermore, the Co3O4 NCs/NF exhibited long-term stability, as shown by chronoamperometry and stepwise tests after 3600 s in the presence of urea under various operating conditions.

Conclusions

Compared to all the fabricated Co3O4 nanostructures, the Co3O4 nanocubes revealed the highest electrocatalytic performance toward urea electro-oxidation in all concentrations. Therefore, Co3O4 NCs/NF is a promising, robust, and efficient electrocatalyst for direct urea fuel cell applications.
Effectiveness and optimal dosage of physiotherapy interventions for Bell palsy: a case study
Authors: Kaushik Himani , Choudhary Avi , Sethi Pooja
Published: November 2024

Background

Bell palsy is a sudden facial nerve paralysis that affects many individuals annually. It significantly impacts patients and their families, leading to a reduced quality of life if left untreated. The International Classification of Functioning, Disability, and Health (ICF) framework focuses on outcome measures, functional limitations, and overall quality of life of the patients. Early diagnosis is crucial for effective management of the condition. In order to standardize clinical practice and contribute to recommendations of certain interventions, this paper focuses on the optimal dosage of physiotherapy intervention for Bell palsy patients, which includes exercise therapy and electrotherapy.

Case presentation

An Indian 33-year-old male visited our physiotherapy department 15 days after being diagnosed with right-sided Bell palsy with unknown aetiology. His chief complaints were right-eye dryness, facial pain, drooping of the face, and difficulty performing facial activities. The outcome measures are the strength duration curve (SD curve), House-Brackmann grading, manual muscle testing, and visual analogue scale (VAS) scale. The physiotherapy intervention includes two primary components: electrotherapy and exercise therapy.

Conclusion

The Kabat rehabilitation technique, along with nerve stimulation and an active exercise regimen, is significantly effective in treating Bell palsy, and the outcome measures show significant improvement with optimal therapy dosage.
Tumor energy metabolism: implications for therapeutic targets
Authors: Hu Youwu , Liu Wanqing , Fang WanDi , Dong Yudi , Zhang Hong , Luo Qing
Published: November 2024

Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug resistance of tumors. The study of tumor energy metabolism has gradually become an emerging field of tumor treatment. Recent studies have shown that epigenetic regulation is closely linked to tumor energy metabolism, influencing the metabolic remodeling and biological traits of tumor cells. This review focuses on the primary pathways of tumor energy metabolism and explores therapeutic strategies to target these pathways. It covers key areas such as glycolysis, the Warburg effect, mitochondrial function, oxidative phosphorylation, and the metabolic adaptability of tumors. Additionally, this article examines the role of the epigenetic regulator SWI/SNF complex in tumor metabolism, specifically its interactions with glucose, lipids, and amino acids. Summarizing therapeutic strategies aimed at these metabolic pathways, including inhibitors of glycolysis, mitochondrial-targeted drugs, exploitation of metabolic vulnerabilities, and recent developments related to SWI/SNF complexes as potential targets. The clinical significance, challenges, and future directions of tumor metabolism research are discussed, including strategies to overcome drug resistance, the potential of combination therapy, and the application of new technologies.
Cellular diversity of human inner ear organoids revealed by single-cell transcriptomics
Authors: Rumbo Mireia , Alsina Berta
Published: November 2024

Human inner ear organoids are three-dimensional tissular structures grown in vitro that recapitulate some aspects of the fetal inner ear and allow the differentiation of inner ear cell types. These organoids offer a system in which to study human inner ear development, mutations causing hearing loss and vertigo, and new therapeutic drugs. However, the extent to which such organoids mimic in vivo human inner ear development and cellular composition remains unclear. Several recent studies have performed single-cell transcriptomics on human inner ear organoids to interrogate cellular heterogeneity, reveal the developmental trajectories of sensory lineages and compare organoid-derived vesicles to the developing human inner ear. Here, we discuss the new insights provided by these analyses that help to define new paths of investigation to understand inner ear development.
Technological assurance of surface quality and operational properties of machine parts
Authors: Lebedev Valeriy , Prokopec Galina , Korol'kov Yuriy , Shishkina Antonina
Published: November 2024

The textbook considers a set of issues related to ensuring the quality of the surface and operational properties of machine parts at the stage of technological preparation of production. The role and importance of technological preparation of production in ensuring the life cycle of products are shown. The characteristic of the operational properties of machine parts is given, the physical essence of the processes and phenomena occurring in the surface layer of parts during their operation is revealed. The interrelation of the operational properties of machine parts with the surface quality is revealed. The physical and technological essence of the methods of forming the quality of the surface layer and methods of their implementation are presented. The approaches of analytical evaluation of the operational properties of parts are systematized and the ways of automation of design and technological preparation of production are shown.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It was prepared in accordance with the educational programs in the direction of "Design and technological support of machine-building industries" and is intended for students of the above-mentioned direction, as well as for engineering and technical workers involved in the technological training of machine-building and repair and restoration industries.
Dwory arcybiskupów gnieźnieńskich do 1493 r. Struktura, urzędy, ludzie
Authors: Włodarski Łukasz
Published: November 2024

A monograph titled Dwory arcybiskupów gnieźnieńskich do 1493 r. Struktura, urzędy (The Courts of Archbishops of Gniezno until 1493. The structure and offices) provides an unprecedented approach towards the issue of medieval bishop’s courts in Polish historiography. In this work, the structure of archbishop’s courts of the 13th-15th c., competence and qualifications of court officials, as well as the personal composition of particular courts have been described. Attempts have also been made to depict the court officials and courtiers as a social group, presenting in this way their social and geographical origins, education, possible earlier or later careers, the size of particular courts and the bureaucratic hierarchy of the time. What is more, an attempt has been made to create a comprehensive summary of biographical entries of people associated with archbishop’s courts.
Historia – Teoria – Praktyka – Wyzwania rachunkowości
Authors: Dziawgo Danuta , Makowska Ewa
Published: November 2024

The volume consists of 17 articles covering a wide range of topics, from the history of accounting through the presentation of selected issues in the field of reporting and sustainable development. Their authors are employees of accounting departments at several Polish universities. The research results presented in the monograph constitute only a fragment of studies on research problems that have been bothering the scientific community in recent years. The topics discussed also include current issues of economic life, to which the field of accounting must also respond.
„Osobliwsza ozdoba konwentu”
Authors: Markiewicz Anna
Published: November 2024

W artykule przedstawiono zarys biografii oraz przeanalizowano działalność przeora krakowskich dominikanów Justa Słowikowskiego (1643–1689). Wywodzący się z krakowskiej rodziny mieszczańskiej Słowikowski przez dwie kadencje, w latach 1681–1684 oraz 1687–1689, pełnił urząd przeora klasztoru Dominikanów w Krakowie. W studium zrekonstruowano przebieg kariery zakonnej dominikanina oraz nakreślono jego aktywność jako przeora krakowskiego konwentu; poruszono również zagadnienie działalności fundacyjnej Słowikowskiego na tym urzędzie oraz współpracy z benefaktorami klasztoru, odnosząc się do prac prowadzonych pod jego patronatem w kościele Świętej Trójcy w Krakowie.
Emilia Urbańczykówna – właścicielka atelier „Secesya” w Podgórzu
Authors: Zbroja Barbara
Published: November 2024

W artykule przedstawiono losy i działalność Emilii Urbańczykówny, fotografki prowadzącej w latach 1915‒1939 zakład „Secesya” znajdujący się w Rynku Podgórskim 9. Urbańczykówna była pierwszą kobietą w Krakowie, która otworzyła własne atelier. Działała w branży przeszło trzydzieści lat. W latach czterdziestych była właścicielką atelier „Luna”, a następnie prowadziła studio „Plastyka”.Praca nie tylko przywraca pamięć o tej zapomnianej postaci, ale obejmuje także nieznane dotychczas losy zakładu fotograficznego „Secesya” („Secesja”), działającego w Podgórzu od końca XIX stulecia, aż po lata sześćdziesiąte XX wieku. W artykule wspomniano o innych fotografach prowadzących ten zakład: Józefie Sebaldzie, Janie Sucheckim, Bazylim Sławińskim, Antonim Walaszku i jego synu Stanisławie. Po działalności atelier zachowały się liczne fotografie przechowywane w instytucjach archiwalnych i muzealnych oraz w zbiorach prywatnych, część z nich nie była wcześniej kojarzona z konkretnymi fotografami.
Why Wages Don’t Fall in Jobs with Incomplete Contracts
Authors: Fongoni Marco , Schaefer Daniel , Singleton Carl
Published: November 2024

We investigate how the incompleteness of an employment contract—discretionary and noncontractible effort—can affect an employer’s decision about cutting nominal wages. Using matched employer-employee payroll data from Great Britain linked to a survey of managers, we find support for the main predictions of a stylized theoretical framework of wage determination: nominal cuts are at most half as likely when managers believe that their employees have significant discretion over how they do their work, although the involvement of employees, via information sharing, reduces this correlation. We also describe how contract incompleteness and wage cuts vary across different jobs. These findings provide the first observational quantitative evidence that managerial beliefs about contractual incompleteness can account for their hesitancy over nominal wage cuts. This has long been conjectured by economists based on anecdotes, qualitative surveys, and laboratory and field experiments.

This paper was accepted by Marie Claire Villeval, behavioral economics and decision analysis.

Funding: M. Fongoni acknowledges funding under the “France 2030” Investment Plan managed by the Agence Nationale de la Recherche [Grant ANR-17-EURE-0020] and funding from the Excellence Initiative of Aix-Marseille University—A*MIDEX. C. Singleton thanks the Economic and Social Research Council and Administrative Data Research UK [Grant ES/T013877/1] for funding the Wage and Employment Dynamics Project.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.02297 .
Amyopathic dermatomyositis with a rapidly progressing interstitial pneumonia
Authors: Logvinova Darija , Žentiņa Dace , Ivanova Kristīne , Buliņa Inita , Kravale Zaiga
Published: November 2024

Background: Clinically amyopathic dermatomyositis (CADM) is a rare subtype of idiopathic inflammatory myositis often linked with the presence of autoantibodies targeting melanoma differentiation-associated protein 5 (MDA5). Patients with CADM are at increased risk of developing rapidly progressing interstitial lung disease, which significantly increases both morbidity and mortality compared to other forms of inflammatory myopathies. While there is no standardized treatment regimen, current therapeutic strategies are generally focused on combination immunosuppressive therapies. Despite early diagnosis and immunosuppressive therapy, the disease remains highly aggressive and is associated with a poor prognosis. Case report: This report describes the case of a 63-year-old previously healthy male who developed acute interstitial pneumonia. Polymerase chain reaction testing for pneumonia pathogens and routine autoimmune antibody screening were both negative. Despite treatment with corticosteroids and broad-spectrum antibiotics, the patient’s condition continued to deteriorate. A multidisciplinary team was assembled, and a myositis antibody panel was ordered, which led to the diagnosis of anti-MDA5 associated clinically amyopathic dermatomyositis. The patient was initiated on treatment with cyclophosphamide, intravenous immunoglobulin, and a calcineurin inhibitor. However, his condition remained critical, and he ultimately succumbed to respiratory failure. Conclusion: In all cases of rapidly progressive interstitial pneumonia of unclear aetiology, anti-MDA5-associated interstitial lung disease should be considered, regardless of the presence or absence of extrapulmonary manifestations. Despite early recognition and aggressive immunosuppressive therapy, patients with anti-MDA5-associated rapidly progressive interstitial lung disease face a mortality risk of up to 80%. A multidisciplinary approach, with collaboration between specialized centres, is crucial for early diagnosis and timely initiation of treatment.
Insights into risk factors of the Metabolic Dysfunction-Associated Steatotic Liver Disease development among patients with schizophrenia
Authors: Rogalski Jakub , Gawlik-Kotelnicka Oliwia , Tomczak Tomasz
Published: November 2024

Introduction: The global burden of the Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) constitutes a significant clinical problem for healthcare systems worldwide. Apparently, a subgroup of patients diagnosed with schizophrenia appears to be particularly vulnerable to the MASLD development. However, exact risk factors in schizophrenia subjects remain unclear to date.

Material and methods: The article is a literature narrative review concentrating on the particular risk factors identification for MASLD development among patients with schizophrenia. Internet scientific bases were searched by three independent investigators throughout February-July 2024 for relevant original and review articles from 2000-2024 using different combinations of MeSH terms: “antipsychotics”, “diabetes”, “dietary habits”, “dyslipidemia”, “inflammation”, “intestinal permeability”, “insulin resistance”, “metabolic-associated fatty liver disease”, “metabolic dysfunction-associated steatotic liver disease”, “metabolic syndrome”, “non-alcoholic fatty liver disease”, “obesity”, “prevention”, “socioeconomic status”, “treatment”. Furthermore, a reference search was conducted to find other important manuscripts. Articles in other language than English were excluded from the search. The Scale for the Assessment of Narrative Review Articles was used to ensure the appropriate quality of this review.

Results: Socioeconomic conditions, improper dietary habits, lack of physical activity, smoking addiction issue, gut microbiota dysfunction or the use of antipsychotics may act as trigger points for the MASLD development among patients with schizophrenia.

Conclusions: The identification of particular risk factors of MASLD development among schizophrenia subjects may help to establish a multidisciplinary healthcare programme primarily aimed at MASLD and its complications prevention, early detection and proper treatment.
Phase formations, Compressive Strength and Microstructure of Environmentally Friendly Thai Lopburi Calcined Clay-Limestone Cement Mixes
Authors:   Advanced Cement-based Materials Research Laboratory, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand, Chaipanich Arnon
Published: November 2024

Limestone
and calcined clay, due to their abundance and sustainability are seen as feasible materials to be used to replace Portland cement in the future. In this work, Portland cement was replaced with calcined clay and limestone at 50 % by weight. In addition to compressive strength, the microstructure and phase characterizations were investigated at 7 and 28 days to determine hydration and pozzolanic reaction of the mixes using thermogravimetric analysis, X-ray diffraction and scanning electron microscopy. When using 20% calcined clay, the 50PC30LS20CC mix showed an increase in the compressive strength by 225% compared to the 50PC50LS mix. Although the compressive strength was still lower than 100 PC control mix, using calcined clay and limestone together lead to a significant reduction in the water absorption compared to 50% LS mix due to the phases formed and the filling effects, and comparable result to 100PC mix was found when calcined clay was used at 20%. In addition to calcium carbonate detected in mixes with limestone, monocarboaluminate phase was also found at 7 days and became clearer at 28 days, especially when there was a combination of calcined clay and limestone in the mix due to the presence of alumina from calcined clay. Moreover, pozzolanic reaction from the use of calcium clay resulted in the increase of C-S-H and C2ASH8 which increased with calcined clay content and corresponds with a reduction in calcium hydroxide and an increase in compressive strength
Exploring the Effect of Incubation pH, Temperature, and In Vitro Digestion on Antioxidant Potential of Mung Bean Protein Hydrolysates
Authors:   Department of Food Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand, Duangmal Kiattisak
Published: November 2024

In
this study, mung bean protein hydrolysates were prepared to evaluate their antioxidant properties under simulated conditions for food processing and in vitro digestion. Mung bean protein isolate, with a protein content of 93.6%, was hydrolyzed by Alcalase at 55 °C, pH 8, for 5-7 hours, using an enzyme-to-substrate ratio of 7%. The degree of hydrolysis (DH) was monitored during enzymatic treatment, reaching selected DH values of 50% and 55% after 360 and 420 minutes, respectively. Hydrolysates collected at 360 (H360) and 420 minutes (H420) demonstrated distinct antioxidant profiles, with H360 exhibiting optimal metal chelating activity (MCA) and ABTS radical scavenging activity. The stability of antioxidant protein hydrolysates derived from mung bean protein was evaluated under different incubation pH levels (4 and 6), at different temperatures (-18°C, 4°C, and 25°C for 24 hours; 63°C for 30 minutes; and 100°C for 5 minutes) and under in vitro digestion. Antioxidant properties were influenced by incubation pH, with higher ABTS scavenging activity observed at pH 6 compared to pH 4. However, MCA did not significantly differ between the two pH levels. Additionally, hydrolysates demonstrated thermal stability, retaining significant antioxidant activity after subjected to various temperature treatment. The hydrolysates also maintained or improved antioxidant capacity post simulated gastrointestinal digestion, highlighting their potential for functional food applications.
Isolation and Identification of Lipase-producing Bacteria from Wastewater Treatment Pond for the Removal of Oil and Grease in Wastewater Treatment
Authors:   Department of Microbiology, Faculty of Science, Srinakharinwirot University, Watthana, Bangkok, 10110, Thailand, Krajangsang Sukhumaporn
Published: November 2024

Ec
osystems and the environment are adversely affected by wastewater containing oil and grease, arising from domestic wastes. In this research, lipase-producing bacteria from a wastewater treatment pond were isolated and the ability to remove oils and grease from synthetic wastewater containing 3% cooking oil was examined. The efficiency of using scrub pad immobilized selected lipase-producing bacteria to remove oil and grease from restaurant wastewater was then investigated. Thirty-one bacterial isolates were obtained from the wastewater, and those that produced lipase were selected using Tween 80 agar. Out of all the isolates, the isolate KS915 and KS303 were chosen due to their noticeably high lipase production efficiency of 1.84±0.07 and 1.48±0.24, respectively. The immobilized KS915 and KS303 had the ability to remove 99.85% and 99.76% of the oil and grease from synthetic wastewater supplemented with 3% cooking oil, respectively. The immobilized KS303 was chosen to remove oil and grease from restaurant wastewater because of its shortened removal time in synthetic wastewater. The immobilized KS303 had an oils and grease removal efficiency of 98.37% after two days, compared to 57.78% for the control after more than ten days. The chemical oxygen demand and biochemical oxygen demand of the treated restaurant wastewater decreased by 48% and 92.1%, respectively. The isolated KS303 was identified as Aeromonas jandaei based on 16S rDNA sequence analysis. Based on these findings, A. jandaei KS303 can be a great source of lipase production and remove oil and grease from domestic wastewater.
The myth of perfect metadata matching
Authors: Tkaczyk Dominika , Buttrick Adam
Published: November 2024

In our previous instalments of the blog series about matching (see part 1 and part 2), we explained what metadata matching is, why it is important and described its basic terminology. In this entry, we will discuss a few common beliefs about metadata matching that are often encountered when interacting with users, developers, integrators, and other stakeholders. Spoiler alert: we are calling them myths because these beliefs are not true! Read on to learn why.
Cravos a contracorrente
Authors: Pereira Maria de Lourdes
Published: November 2024

Apresenta-se aqui uma seleção de textos do primeiro volume dos diários de Vergílio Ferreira, Conta-Corrente I (1980), os quais dão conta das suas vivências em torno da revolução, entre 1973 e 1976, e revelam a evolução dos acontecimentos depois dos primeiros dias de entusiasmo.
La censura contra Els mallorquins, de Josep Melià (1964-1967)
Authors: Marimon Riutort Antoni
Published: November 2024

Amb Els mallorquins, redactat entre 1963 i 1964, un jove Josep Melià va aconseguir completar la tasca de reflexió identitària iniciada per Jaume Vicenç Vives i continuada brillantment per Joan Fuster. Contra tot pronòstic, la censura va esser molt dura contra Els mallorquins. S’ha de destacar un informe procedent de la Delegación Provincial de Baleares de Información y Turismo que l’acusava de catalanista radical, de fer propaganda de personalitats separatistes i de distorsionar la realitat mallorquina.
Aquest informe, així com un altre de més moderat que també era d’autoria mallorquina, demostrava que les autoritats franquistes tenien un bon coneixement dels cercles culturals mallorquins. Es va iniciar un llarg procés de negociació entre l’autor i les autoritats censores en el qual va intervenir personalment el director general d’Información, Carlos Robles Piquer. Finalment, el març de 1967 l’obra es va poder publicar. Tot i que s’havien suprimit nombrosos passatges i expressions com «nació» o «nacional», no es van desvirtuar les tesis principals de l’obra, que eren la catalanitat històrica i cultural de Mallorca i la denúncia d’un llarg procés de castellanització cultural, desenvolupat amb la col·laboració sobretot de la burgesia i l’apatia de la massa de la població.
The role of the Permanent People’s Tribunal in the face of ecogenocide in Cerrado
Authors: Bogado Melchiors Rafaela , Agatha França Karine , De Nardin Budó Marília
Published: November 2024

This paper seeks to understand how the Permanent Peoples Tribunal, in its structure and organisation, articulates the notions of rights violations, vulnerabilities and justice, based on the subversion of the notion of victim (active), memory (which challenges history) and justice (concrete and symbolic). To do this, we start with case number 49, also known as the Permanent Peoples' Tribunal in Defence of the Cerrado Territories, which was conducted in 2021 and 2022 in Brazil. The theoretical framework is based on studies of the criminality of the powerful and environmental justice from a decolonial perspective. We also articulate the theoretical tools brought by Achille Mbembe and Judith Butler. The work is structured in three parts. In the first part, we look at the creation of the Permanent Peoples' Tribunal and describe the case of the Cerrado Tribunal. We then discuss the case from the point of view of the concept of necropolitics in order, finally, to bring notions of resistance into line with some of the postulates of transitional justice.
Crónica de una muerte anunciada en las cárceles peruanas: Inconmovilidad del sistema penal en tiempos de pandemia, desde la perspectiva de los actores
Authors: Pérez Mercado Wendy Carolina
Published: November 2024

Comprender las prácticas que hacen posible la existencia del encarcelamiento masivo en el Perú es una tarea mandatoria de abordar, aún más cuando esta habitualidad persiste en el marco de la pandemia por COVID-19. Con ese propósito, la autora presenta, desde la mirada de los actores, un análisis del modo de funcionamiento del sistema penal peruano, a través de la evaluación de las medidas que se emitieron para hacer frente a la pandemia, del juego político que hubo detrás de su creación y de las dificultades y/o limitaciones que se generaron para su implementación. El artículo se divide en tres secciones: la primera muestra el cuadro clínico del encarcelamiento masivo en el Perú y las características reales de la cárcel peruana; la segunda apunta al análisis y evaluación de la gestión de la problemática carcelaria desde una perspectiva cuantitativa y cualitativa y la tercera presenta las evidencias de la inconmovilidad del sistema penal en el Perú.
Nota Editorial, Nº 27 (noviembre de 2024)
Authors: Rivera Beiras Iñaki
Published: November 2024

Nota Editorial número 27 (noviembre de 2024)
formación del pensamiento histórico a través de la interpretación de imágenes de El Cartel de Medellín (1976-1993)
Authors: Ochoa Gómez Adriana Zulima
Published: November 2024

En este artículo se exponen los hallazgos encontrados en una intervención didáctica cuyo objetivo fue cómo promover el pensamiento histórico en los estudiantes de grado noveno a partir de la interpretación de imágenes históricas. Para ello se realizó una investigación de enfoque cualitativo con un alcance interpretativo, en una institución rural del municipio de Itagüí, Antioquia. A los estudiantes se les proyectó una serie de imágenes relacionadas con El Cartel de Medellín. Éstas estaban acompañadas con unas preguntas de control que permitieron identificar los niveles de lectura de las imágenes históricas. La implementación sistemática de las imágenes sobre El Cartel de Medellín dio como resultado que los estudiantes superaron los obstáculos de una lectura realista ingenua, y avanzaron progresivamente hacia una lectura realista, interpretativa y/o contextualizada. Asimismo, alcanzaron una contextualización histórica de El Cartel de Medellín.
"Adopt, don't shop!": Escritura en inglés y aprendizaje interlingüístico del adjetivo en primaria
Authors: Reig Aina , Torralba Gloria , Sempere Joan V.
Published: November 2024

Este artículo presenta una investigación basada en el diseño y la implementación en un aula de 6.º de Primaria de Adopt, don’t shop!, una secuencia didáctica de gramática basada en el modelo Egramint (SDGE). La SDGE aúna la enseñanza de la gramática, concretamente del adjetivo, y la escritura en lengua inglesa en el marco de un reto social. El objetivo principal de este trabajo es exponer los resultados de la implementación de la SDGE. Específicamente, se pretende identificar los aprendizajes desarrollados por el alumnado participante en la investigación a raíz de la intervención. Además, se propone validar la secuencia como instrumento que permita aunar la enseñanza de la gramática y de la escritura, y poder ofrecerla como material didáctico para el aula. Los resultados permiten afirmar que la orientación metodológica de la SDGE, que conecta la lengua y el uso, contribuye al aprendizaje de la escritura en inglés y, al mismo tiempo, al desarrollo de conocimientos gramaticales.
IA generativa en educación: Tampoco era para tanto … ¿o sí?
Authors: Llorens Largo Faraón
Published: November 2024

Editorial
Crèdits
Authors: Sospedra-Roca Rafael
Published: November 2024

Clica per veure la portada de la revista
La memòria dels objectes. El llegat material dels escenaris de conflicte; el cas de les fosses comunes
Authors: Maeso Blanco Lorena
Published: November 2024

Les troballes d’objectes que es recuperen durant les exhumacions en fosses comunes tenen un valor cabdal de gran importància per la mateixa pertinença i càrrega sentimental de l’objecte en si, però també per les dades d’informació que els experts en poden extreure i posteriorment estudiar. Els objectes són segurament la prova tangible d’una humanitat que acompanya a les restes òssies exhumades i que, com a tals, tenen el que simbòlicament es pot anomenar com el ‘poder’ d’explicar el passat en un moment present o fer de nexe entre passat-recent.

Aquest article té per objectiu assentar les bases d’una anàlisi i reflexió al voltant de les possibilitats de fer servir aquests objectes materials en clau didàctica i emmarcats dins del patrimoni de memòria i de l’arqueologia del conflicte. Per fer-ho, es vol centrar el focus en l’estudi de casos de diverses pràctiques didàctiques fetes a partir d’exhumacions en fosses comunes de conflictes bèl·lics contemporanis, tot centrant una primera part en les fosses de la guerra civil a Espanya.

S’analitzarà quins usos dels objectes poden ser efectius en l’actualitat per donar a conèixer al conjunt de la ciutadania i a les comunitats educatives, des d’una visió professional i científica, però també divulgativa, una temàtica complexa i delicada sovint no exempta de problemàtiques. Quins recursos i estratègies s’han emprat i quines noves vies de divulgació podrien tenir cabuda. Es vol fer èmfasi a investigar quines diferències i similituds podem trobar en altres processos patrimonialitzadors de la memòria. Explorar quina finalitat se n’ha tret dels objectes recuperats i si aquestes pràctiques poden contribuir a la recuperació de la memòria històrica i a la conscienciació de l’impacte que suposa per una comunitat un conflicte bèl·lic.
Los periódicos de las Brigadas Internacionales
Authors: Arévalo Molina Jacinto M.
Published: November 2024

Es bien conocida la abundante literatura creada sobre las Brigadas Internacionales (BBII) durante su intervención en la Guerra Civil Española (1936 a 1939) en favor de la República, y mucho más la producida posteriormente a su retirada y una vez acabada la guerra, bien por sus excombatientes o por historiadores que estudiaron los pormenores de aquellas peculiares unidades.

En cambio, es muy poco conocida la literatura producida por las mismas BBII durante su intervención en el conflicto, unos cuantos libros de los que hay algunos estudios, y una cantidad ingente de periódicos dirigidos a los combatientes de esas unidades, los brigadistas, bien en español o en los idiomas mayoritarios de cada colectivo. Recordemos que hubo voluntarios de más de cincuenta nacionalidades, de los que apenas hay estudios detallados.

Se presenta una recopilación de los periódicos publicados por las BBII, de los que se han localizado más de un centenar hasta el momento. De ellos se da una breve descripción: idioma o idiomas en que está escrito, unidad que lo publica, fechas de publicación, imprenta y localidad, números publicados y cuantos se conocen, páginas de los ejemplares y algunas características que los definan.
Entre el culto a la feminidad y la reivindicación feminista: las revistas femeninas en Marruecos en la segunda mitad del siglo XX
Authors: González Navarro Ana
Published: November 2024

En la década de 1960 en Marruecos, coincidiendo con una época de cambio cultural y político, la prensa marroquí vivió un nuevo fenómeno: la aparición de revistas concebidas por, para y sobre mujeres. Este artículo parte de la idea de que el estudio de estas revistas resulta esencial tanto para entender las políticas de género como para trazar la historia intelectual del feminismo en Marruecos. Por ello, propone un recorrido por el desarrollo de la prensa femenina marroquí desde su surgimiento en los años sesenta hasta la actualidad, para analizar la evolución de sus concepciones sobre el papel que debían desempeñar las mujeres en la sociedad marroquí. Desde una perspectiva de género y feminista, el artículo examina el contenido de estas revistas que contribuyeron tanto a perpetuar estereotipos patriarcales sobre las mujeres marroquíes como a plasmar las primeras reivindicaciones feministas en Marruecos.