bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Signatures Based on Ferroptosis- and Immune-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Authors: Xing Chaoqun , Yin Huiming , Yao Zhi-Yong , Xing Xiao-Liang
Published: January 2022

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are among the most common malignancies of the female genital tract. Ferroptosis and immunity regulate each other and play important roles in the progression of CESC. The present study aimed to screen ferroptosis- and immune-related differentially expressed genes (FI-DEGs) to identify suitable prognostic signatures for patients with CESC. We downloaded the RNAseq count data and corresponding clinical information of CESC patients from The Cancer Genome Atlas database; obtained recognized ferroptosis- and immune-related genes from the FerrDb and ImmPort databases, respectively; and screened for suitable prognostic signatures using a series of bioinformatics analyses. We identified eight FI-DEGs (CALCRL, CHIT1, DES, DUOX1, FLT1, HELLS, SCD, and SDC1) that were independently correlated with the overall survival of patients with CESC. The prediction model constructed using these eight FI-DEGs was also independently correlated with overall survival. Both the sensitivity and specificity of the prediction model constructed using these eight signatures were over 60%. The comprehensive index of ferroptosis and immune status was significantly correlated with the immunity of patients with CESC. In conclusion, the risk assessment model constructed with these eight FI-DEGs predicted the CESC outcomes. Therefore, these eight FI-DEGs could serve as prognostic signatures for CESC.
Overview of Cancer Control in Armenia and Policy Implications
Authors: Bedirian Karen , Aghabekyan Tigran , Mesrobian Arianna , Shekherdimian Shant , Zohrabyan Davit , Safaryan Liana , Sargsyan Lilit , Avagyan Armen , Harutyunyan Lilit , Voskanyan Astghik , Tadevosyan Artashes , Melik-Nubaryan Davit , Khachatryan Parandzem , Saghatelyan Tatul , Kostanyan Mher , Vardevanyan Hovhannes , Hovhannisyan Marine , Sarkisian Tamara , Sargsyan Karine , Babikyan Davit , Tananyan Armen , Danielyan Samvel , Muradyan Armen , Tamamyan Gevorg , Bardakhchyan Samvel
Published: January 2022

Cancer is the second leading cause of death in Armenia. Over the past two decades, the country has seen a significant rise in cancer morbidity and mortality. This review aims to provide up-to-date info about the state of cancer control in Armenia and identify priority areas of research. The paper analyzes published literature and local and international statistical reports on Armenia and similar countries to put numbers into context. While cancer detection, diagnosis, and treatment are improving, the prevalence of risk factors is still quite high and smoking is widespread. Early detection rates are low and several important screening programs are absent. Diagnosis and treatment methods are not standardized; there is a lack of treatment accessibility due to insufficient government coverage and limited availability of essential medicines. Overall, there is room for improvement in this sector, as research is limited and multidisciplinary approaches to the topic are rare.
Tumor- and Osteoblast-Derived Periostin in Prostate Cancer bone Metastases
Authors: Sun Chuan-Yu , Mi Yuan-Yuan , Ge Sheng-Yang , Hu Qing-Feng , Xu Ke , Guo Yi-Jun , Tan Yi-Fan , Zhang Yang , Zhong Fan , Xia Guo-Wei
Published: January 2022

Exploring the biological function of periostin (POSTN) in prostate cancer (PCa) bone metastasis is of importance. It was observed that the expression of POSTN was high in PCa, especially highest in PCa metastasized to bone. In this study, we found that inhibiting POSTN in PCa cells could significantly alleviate PCa bone metastasis in vivo, suggesting POSTN is a promising therapeutic target. Since, due to the secreted expression of POSTN in osteoblasts and PCa, we hypothesized the positive feedback loop between osteoblasts and PCa mediated by POSTN in PCa bone metastasis. The in vitro experiments demonstrated that osteoblast-derived POSTN promoted PCa cell proliferation and invasion and PCa cell-derived POSTN promotes proliferation of osteoblasts. Furthermore, we found that POSTN regulated PCa and osteoblast function through integrin receptors. Finally, 18F-Alfatide II was used as the molecule probe of integrin αvβ3 in PET-CT, revealing high intake in metastatic lesions. Our findings together indicate that targeting POSTN in PCa cells as well as in the osteoblastic may be an effective treatment for PCa bone metastasis.
Comprehensive Analysis of Cell Cycle-Related Genes in Patients With Prostate Cancer
Authors: Liu Zehua , Pan Rongfang , Li Wenxian , Li Yanjiang
Published: January 2022

This study aimed to identify critical cell cycle-related genes (CCRGs) in prostate cancer (PRAD) and to evaluate the clinical prognostic value of the gene panel selected. Gene set variation analysis (GSVA) of dysregulated genes between PRAD and normal tissues demonstrated that the cell cycle-related pathways played vital roles in PRAD. Patients were classified into four clusters, which were associated with recurrence-free survival (RFS). Moreover, 200 prognostic-related genes were selected using the Kaplan–Meier (KM) survival analysis and univariable Cox regression. The prognostic CCRG risk score was constructed using random forest survival and multivariate regression Cox methods, and their efficiency was validated in Memorial Sloan Kettering Cancer Center (MSKCC) and GSE70770. We identified nine survival-related genes: CCNL2, CDCA5, KAT2A, CHTF18, SPC24, EME2, CDK5RAP3, CDC20, and PTTG1. Based on the median risk score, the patients were divided into two groups. Then the functional enrichment analyses, mutational profiles, immune components, estimated half-maximal inhibitory concentration (IC50), and candidate drugs were screened of these two groups. In addition, the characteristics of nine hub CCRGs were explored in Oncomine, cBioPortal, and the Human Protein Atlas (HPA) datasets. Finally, the expression profiles of these hub CCRGs were validated in RWPE-1 and three PRAD cell lines (PC-3, C4-2, and DU-145). In conclusion, our study systematically explored the role of CCRGs in PRAD and constructed a risk model that can predict the clinical prognosis and immunotherapeutic benefits.
Chronic Pelvic Pain and Sexual Dysfunction Among Females and Males Receiving Treatment for Opioid Use Disorder
Authors: Reichmann Geetika , Parlier-Ahmad Anna Beth , Beck Lori , Thakkar Bhushan , Alappattu Meryl , Boissoneault Jeff , Martin Caitlin E.
Published: January 2022

Introduction: Chronic pain brings complexity to opioid use disorder (OUD). Psychosocial and neurobiological risks for Chronic Pelvic Pain (CPP) and OUD overlap. The primary objective of this exploratory study is to compare sex-specific prevalence of CPP and sexual dysfunction between individuals receiving buprenorphine for OUD and a comparison group receiving treatment for other chronic medical conditions (CMC).

Methods: Participants from an OUD treatment (n = 154) and primary care clinic (n = 109) completed a survey between July 2019 and February 2020 assessing reproductive and sexual health. Sex-stratified CPP and pain interference measures were adapted from the Brief Pain Inventory for females, and for males, the Brief Male Sexual Function Inventory and NIH Chronic Prostatitis Symptom Index. The Male and Female Sexual Function Index assessed sexual dysfunction. Prevalence of CPP and sexual dysfunction between groups were compared using Pearson χ2 and Fisher's Exact tests.

Results: Participants were 54.4% female and 75.0% Black with almost half having a psychiatric diagnosis. Among OUD females, the highest pain severity reported was for menstrual-related pain, and for OUD males, testicular pain. CPP most interfered with mood in OUD females vs. sleep and enjoyment of life in OUD males. There were no differences in prevalence for global sexual dysfunction with 91.6% of females and 84.2% of males screening positive across groups.

Discussion/Implications: CPP and sexual dysfunction are important components of wellness and may play a role in OUD recovery trajectories. The value of addressing CPP and sexual dysfunction in tailored comprehensive, sex-informed OUD treatment approaches should be further investigated.
Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy
Authors: Nomura Haru , Kuruppu Sanjaya , Rajapakse Niwanthi W.
Published: January 2022

Despite current therapies for diabetic nephropathy, many patients continue to progress to end-stage renal disease requiring renal replacement therapy. While the precise mechanisms underlying diabetic nephropathy remain to be determined, it is well established that chronic activation of the renin angiotensin aldosterone system (RAAS) plays a substantial role in the pathogenesis of diabetic nephropathy. Angiotensin converting enzyme 2 (ACE2), the enzyme responsible for activating the reno-protective arm of the RAAS converts angiotensin (Ang) II into Ang 1-7 which exerts reno-protective effects. Chronic RAAS activation leads to kidney inflammation and fibrosis, and ultimately lead to end-stage kidney disease. Currently, angiotensin converting enzyme inhibitors and Ang II receptor blockers are approved for renal fibrosis and inflammation. Targeting the reno-protective arm of the RAAS should therefore, provide further treatment options for kidney fibrosis and inflammation. In this review, we examine how targeting the reno-protective arm of the RAAS can ameliorate kidney inflammation and fibrosis and rescue kidney function in diabetic nephropathy. We argue tissue ACE2 stimulation provides a unique and promising therapeutic approach for diabetic nephropathy.
A Major Quantitative Trait Loci Cluster Controlling Three Components of Yield and Plant Height Identified on Chromosome 4B of Common Wheat
Authors: Wen Shaozhe , Zhang Minghu , Tu Keling , Fan Chaofeng , Tian Shuai , Bi Chan , Chen Zelin , Zhao Huanhuan , Wei Chaoxiong , Shi Xintian , Yu Jiazheng , Sun Qixin , You Mingshan
Published: January 2022

Wheat yield is not only affected by three components of yield, but also affected by plant height (PH). Identification and utilization of the quantitative trait loci (QTL) controlling these four traits is vitally important for breeding high-yielding wheat varieties. In this work, we conducted a QTL analysis using the recombinant inbred lines (RILs) derived from a cross between two winter wheat varieties of China, “Nongda981” (ND981) and “Nongda3097” (ND3097), exhibiting significant differences in spike number per unit area (SN), grain number per spike (GNS), thousand grain weight (TGW), and PH. A total of 11 environmentally stable QTL for these four traits were detected. Among them, four major and stable QTLs (QSn.cau-4B-1.1, QGns.cau-4B-1, QTgw.cau-4B-1.1, and QPh.cau-4B-1.2) explaining the highest phenotypic variance for SN, GNS, TGW, and PH, respectively, were mapped on the same genomic region of chromosome 4B and were considered a QTL cluster. The QTL cluster spanned a genetic distance of about 12.3 cM, corresponding to a physical distance of about 8.7 Mb. Then, the residual heterozygous line (RHL) was used for fine mapping of the QTL cluster. Finally, QSn.cau-4B-1.1, QGns.cau-4B-1, and QPh.cau-4B-1.2 were colocated to the physical interval of about 1.4 Mb containing 31 annotated high confidence genes. QTgw.cau-4B-1.1 was divided into two linked QTL with opposite effects. The elite NILs of the QTL cluster increased SN and PH by 55.71–74.82% and 14.73–23.54%, respectively, and increased GNS and TGW by 29.72–37.26% and 5.81–11.24% in two environments. Collectively, the QTL cluster for SN, GNS, TGW, and PH provides a theoretical basis for improving wheat yield, and the fine-mapping result will be beneficial for marker-assisted selection and candidate genes cloning.
Molecular Characterization Revealed the Role of Thaumatin-Like Proteins of Bread Wheat in Stress Response
Authors: Sharma Alok , Sharma Himanshu , Rajput Ruchika , Pandey Ashutosh , Upadhyay Santosh Kumar
Published: January 2022

Thaumatin-like proteins (TLPs) are related to pathogenesis-related-5 (PR-5) family and involved in stress response. Herein, a total of 93 TLP genes were identified in the genome of Triticum aestivum. Further, we identified 26, 27, 39, and 37 TLP genes in the Brachypodium distachyon, Oryza sativa, Sorghum bicolor, and Zea mays genomes for comparative characterization, respectively. They could be grouped into small and long TLPs with conserved thaumatin signature motif. Tightly clustered genes exhibited conserved gene and protein structure. The physicochemical analyses suggested significant differences between small and long TLPs. Evolutionary analyses suggested the role of duplication events and purifying selection in the expansion of the TLP gene family. Expression analyses revealed the possible roles of TLPs in plant development and abiotic and fungal stress response. Recombinant expression of TaTLP2-B in Saccharomyces cerevisiae provided significant tolerance against cold, heat, osmotic, and salt stresses. The results depicted the importance of TLPs in cereal crops that would be highly useful in future crop improvement programs.
Children’s Internet Use, Self-Reported Life Satisfaction, and Parental Mediation in Europe: An Analysis of the EU Kids Online Dataset
Authors: Milosevic Tijana , Kuldas Seffetullah , Sargioti Aikaterini , Laffan Derek A. , O’Higgins Norman James
Published: January 2022

The present research examines how children’s time spent online is associated with their perceived life satisfaction accounting for their age, gender, socio-economic status (SES), emotional problems, country, and family environmental factors. This article is based on the data of the large scale cross-sectionalEU Kids Onlinesurvey from 16 European countries with nationally representative samples of children aged 9–17 (N= 11,200,Mage= 13.3, SD = 2.36; 50.6% boys, 49.4% girls). The results indicated that the time children spent online appeared to have no considerable negative effect on their self-reported life satisfaction (SRLS). Comparatively, the positive effects of children’s SES and family environment accounted for 43% of the overall 50% of the variance in children’s SRLS scores. Considering that children’s SES alone accounted for 42% of the variance, children’s emotional problems, country of residence, and enabling parental mediation accounted for the remaining 3, 4, and 1% of the variance, respectively. In line with previous studies that urge caution when discussing the negative influence of time spent online on children’s mental health and overall wellbeing, the current findings suggest that social-ecological characteristics and how children use the Internet, need to be examined further.
The Relationship Between Long Working Hours and Stress Responses in Junior High School Teachers: A Nationwide Survey in Japan
Authors: Matsushita Masateru , Yamamura Schuhei
Published: January 2022

Background: Long working hours and mental health problems among teachers are a concern in Japan. More specifically, it has been reported that junior high school teachers tend to work overtime. In this study, examined the working hours of junior high school teachers in public schools and investigated the association between overtime work and stress responses across job titles.

Methods: From June to December 2018, 54,772 teachers in public junior high schools completed a web-based nationwide survey regarding occupational stress and submitted self-evaluated working hours per day of the previous month. Psychological and physical stress responses were assessed using the Brief Job Stress Questionnaire.

Results: Results showed that 59.6% of the participants worked 11 h or more per day. Additionally, the length of working hours significantly differed across job titles (χ2 (30) = 5295.8, p < 0.001, Cramér’s V = 0.14). With respect to tenured teachers, sex (female), age, taking charge of the class, number of working years in the same school, working hours of 10 to 11 h, 11 to 12 h, 12 to 13 h, and 13 h or more were significantly associated with high stress, compared to those who worked less than 9 h per day. Moreover, for fixed-term teachers, sex (female), age, working hours of 9 to 10 h, 10 to 11 h, 11 to 12 h, 12 to 13 h, and 13 h or more were related with more stress as compared to those who worked less than 9 h per day. On the other hand, there was no significant relationship between long working hours and stress response among vice-principals, even though they tended to work the longest hours.

Conclusion: We verified that Japanese junior high school teachers work long hours. Long working hours were associated with stress responses in both tenured and fixed-term teachers, but not in vice-principals. However, vice-principals work the longest hours among teachers, and we suggest that these long working hours may be a hidden problem that is often overlooked.
As Steady as a Rock! Gaining Insight in Recruitment and Retention Among Primary School Children With Behavioural Problems in Sport Mix Club
Authors: Prevo Lotte , Jansen Maria , Van Kann Dave , Kremers Stef
Published: January 2022

The number of children dealing with behavioural problems is increasing. A major challenge in many health-supportive programmes is the recruitment and retention of these children. In the current study, Sport Mix Club (SMC), an approach to enhance socioemotional disorders of 4- to 12-year-old children through sport classes in municipality Vaals, the Netherlands, is used as an illustration. Where many studies faced difficulties getting and keeping children in their interventions, SMC overcame this challenge. Therefore, we decided to explore “What factors contribute to enhanced recruitment and retention procedures among children with behavioural problems in Sport Mix Club?” A qualitative case study design using the analysis of the administrative logbook of the SMC coach and trainees, individual interviews with the SMC coach, trainees (n = 2), school teachers (n = 3) and parents of participating children (n = 9), and four focus group interviews with children (n = 13) were carried out. During the recruitment and retention of SMC, the human psychological need of relatedness seemed to be of crucial value. The fact that the SMC coach: (1) made efforts to become a familiar face for children, parents and community partners beforehand; (2) showed enthusiasm; and (3) placed her focus on having fun as opposed to the children's problems, seemed to be decisive in the process of getting children to participate in SMC and retaining their participation.
Gradient Legal Personhood for AI Systems—Painting Continental Legal Shapes Made to Fit Analytical Molds
Authors: Mocanu Diana Mădălina
Published: January 2022

What I propose in the present article are some theoretical adjustments for a more coherent answer to the legal “status question” of artificial intelligence (AI) systems. I arrive at those by using the new “bundle theory” of legal personhood, together with its accompanying conceptual and methodological apparatus as a lens through which to look at a recent such answer inspired from German civil law and named Teilrechtsfähigkeit or partial legal capacity. I argue that partial legal capacity is a possible solution to the status question only if we understand legal personhood according to this new theory. Conversely, I argue that if indeed Teilrechtsfähigkeit lends itself to being applied to AI systems, then such flexibility further confirms the bundle theory paradigm shift. I then go on to further analyze and exploit the particularities of Teilrechtsfähigkeit to inform a reflection on the appropriate conceptual shape of legal personhood and suggest a slightly different answer from the bundle theory framework in what I term a “gradient theory” of legal personhood.
Deep Machine Learning for Oral Cancer: From Precise Diagnosis to Precision Medicine
Authors: Alabi Rasheed Omobolaji , Almangush Alhadi , Elmusrati Mohammed , Mäkitie Antti A.
Published: January 2022

Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide and its incidence is on the rise in many populations. The high incidence rate, late diagnosis, and improper treatment planning still form a significant concern. Diagnosis at an early-stage is important for better prognosis, treatment, and survival. Despite the recent improvement in the understanding of the molecular mechanisms, late diagnosis and approach toward precision medicine for OSCC patients remain a challenge. To enhance precision medicine, deep machine learning technique has been touted to enhance early detection, and consequently to reduce cancer-specific mortality and morbidity. This technique has been reported to have made a significant progress in data extraction and analysis of vital information in medical imaging in recent years. Therefore, it has the potential to assist in the early-stage detection of oral squamous cell carcinoma. Furthermore, automated image analysis can assist pathologists and clinicians to make an informed decision regarding cancer patients. This article discusses the technical knowledge and algorithms of deep learning for OSCC. It examines the application of deep learning technology in cancer detection, image classification, segmentation and synthesis, and treatment planning. Finally, we discuss how this technique can assist in precision medicine and the future perspective of deep learning technology in oral squamous cell carcinoma.
New Developments in Virtual Reality-Assisted Treatment of Aggression in Forensic Settings: The Case of VRAPT
Authors: González Moraga Fernando Renee , Klein Tuente Stéphanie , Perrin Sean , Enebrink Pia , Sygel Kristina , Veling Wim , Wallinius Märta
Published: January 2022

Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity of psychological research. Recently, a new treatment for aggression using VR as the treatment environment, Virtual Reality Aggression Prevention Training (VRAPT), was developed to provide realistic and safe environments for participants to practice aggression management. In its current revised version, VRAPT is conceptualized as a form of cognitive behavioral therapy with its theoretical background in the General Aggression Model. Its purpose is to increase awareness of, and improve control over, one’s own aggression and that of others through social interactions in individually tailored virtual environments. This manuscript describes how the lessons learned from the first randomized controlled trial of VRAPT have been applied to further develop the method and discusses challenges and future directions for VR-assisted treatment of aggression in forensic settings. VRAPT is a new psychological treatment for aggression and the coming years will provide expanded scientific evidence for further developments and adaptations.
Molecular Characterization of a Novel Budgerigar Fledgling Disease Virus Strain From Budgerigars in China
Authors: Hu Xiaoliang , Cai Dongdong , Liu Siru , Li Yan , Chen Lulu , Luo Guangmei , Pu Hongli , He Yucan , Liu Xiangxiao , Zhao Lili , Cao Hongzhi , Yang Tiankuo , Tian Zhige
Published: January 2022

Budgerigar fledgling disease virus (BFDV) is the causative polyomavirus of budgerigar fledgling disease, an important avian immunosuppressive disease in budgerigars (Melopsittacus undulatus). In the current study, we explored the etiological role and molecular characteristics of BFDV. We identified a novel BFDV strain, designated as SC-YB19, belonging to a unique cluster with three other domestic strains (WF-GM01, SD18, and APV-P) and closely related to Polish isolates based on complete sequences. Sequence analysis showed that SC-YB19 had an 18-nucleotide (nt) deletion in the enhancer region, corresponding to the sequence position 164–181 nt, which differed significantly from all other BFDV strains. Based on sequence alignment, three unique nucleotide substitutions were found in VP4 (position 821), VP1 (position 2,383), and T-antigen (position 3,517) of SC-YB19, compared with SD18, WF-GM01, QDJM01, HBYM02, APV7, and BFDV1. Phylogenetic analyses based on complete sequences suggested that SC-YB19, along with the domestic WF-GM01, SD18, and APV-P strains, formed a single branch and were closely related to Polish, Japanese, and American isolates. These results demonstrate that BFDV genotype variations are co-circulating in China, thus providing important insight into BFDV evolution.
Cu-Ni-Based Alloys from Nanopowders as Potent Thermoelectric Materials for High-Power Output Applications
Authors: Wolf Mario , Flormann Jan , Steinhoff Timon , Gerstein Gregory , Nürnberger Florian , Maier Hans Jürgen , Feldhoff Armin
Published: January 2022

A new approach for the development of thermoelectric materials, which focuses on a high-power factor instead of a large figure of merit zT, has drawn attention in recent years. In this context, the thermoelectric properties of Cu-Ni-based alloys with a very high electrical conductivity, a moderate Seebeck coefficient, and therefore a high power factor are presented as promising low-cost alternative materials for applications aiming to have a high electrical power output. The Cu-Ni-based alloys are prepared via an arc melting process of metallic nanopowders. The heavy elements tin and tungsten are chosen for alloying to further improve the power factor while simultaneously reducing the high thermal conductivity of the resulting metal alloy, which also has a positive effect on the zT value. Overall, the samples prepared with low amounts of Sn and W show an increase in the power factor and figure of merit zT compared to the pure Cu-Ni alloy. These results demonstrate the potential of these often overlooked metal alloys and the utilization of nanopowders for thermoelectric energy conversion.
Direct Double Coating of Carbon and Nitrogen on Fluoride-Doped Li4Ti5O12 as an Anode for Lithium-Ion Batteries
Authors: Noerochim Lukman , Wibowo Alvalo Toto , Widyastuti  , Subhan Achmad , Prihandoko Bambang , Caesarendra Wahyu
Published: January 2022

Graphite as a commercial anode for lithium-ion batteries has significant safety concerns owing to lithium dendrite growth at low operating voltages. Li4Ti5O12 is a potential candidate to replace graphite as the next-generation anode of lithium-ion batteries. In this work, fluoride-doped Li4Ti5O12 was successfully synthesized with a direct double coating of carbon and nitrogen using a solid-state method followed by the pyrolysis process of polyaniline. X-ray diffraction (XRD) results show that the addition of fluoride is successfully doped to the spinel-type structure of Li4Ti5O12 without any impurities being detected. The carbon and nitrogen coating are distributed on the surface of Li4Ti5O12 particles, as shown in the Scanning Electron Microscopy–Energy Dispersive X-ray Spectroscopy (SEM-EDS) image. The Transmission Electron Microscopy (TEM) image shows a thin layer of carbon coating on the Li4Ti5O12 surface. The fluoride-doped Li4Ti5O12 has the highest specific discharge capacity of 165.38 mAh g−1 at 0.5 C and capacity fading of 93.51% after 150 cycles compared to other samples, indicating improved electrochemical performance. This is attributed to the synergy between the appropriate amount of carbon and nitrogen coating, which induced a high mobility of electrons and larger crystallite size due to the insertion of fluoride to the spinel-type structure of Li4Ti5O12, enhancing lithium-ion transfer during the insertion/extraction process.
Update on Malignancy in Myositis—Well-Established Association with Unmet Needs
Authors: Opinc Aleksandra H. , Makowska Joanna S.
Published: January 2022

Idiopathic inflammatory myopathies are a group of rare connective tissue diseases with a well-documented association with malignancy. The mechanisms underlying the increased risk of neoplasms in the course of myositis are not fully understood. The Pubmed database has been thoroughly screened for articles concerning cancer-associated myositis (CAM). The article summarizes the current state of knowledge on the epidemiology and pathogenesis of CAM. Furthermore, it analyses potential risk and protective factors for developing CAM, with particular emphasis on the association with distinct serological profiles. The review summarizes recommendations proposed so far for the management of CAM and presents a novel scheme for cancer screening proposed by the authors. Moreover, promising areas requiring further research were indicated.
Molecular Targeted Therapies: Time for a Paradigm Shift in Medulloblastoma Treatment?
Authors: Gatto Lidia , Franceschi Enrico , Tosoni Alicia , Di Nunno Vincenzo , Bartolini Stefania , Brandes Alba Ariela
Published: January 2022

Medulloblastoma is a rare malignancy of the posterior cranial fossa. Although until now considered a single disease, according to the current WHO classification, it is a heterogeneous tumor that comprises multiple molecularly defined subgroups, with distinct gene expression profiles, pathogenetic driver alterations, clinical behaviors and age at onset. Adult medulloblastoma, in particular, is considered a rarer “orphan” entity in neuro-oncology practice because while treatments have progressively evolved for the pediatric population, no practice-changing prospective, randomized clinical trials have been performed in adults. In this scenario, the toughest challenge is to transfer the advances in cancer genomics into new molecularly targeted therapeutics, to improve the prognosis of this neoplasm and the treatment-related toxicities. Herein, we focus on the recent advances in targeted therapy of medulloblastoma based on the new and deeper knowledge of disease biology.
Upfront Chemotherapy Followed by Stereotactic Body Radiation Therapy with or without Surgery in Older Patients with Localized Pancreatic Cancer: A Single Institution Experience and Review of the Literature
Authors: Reddy Abhinav V. , Sehgal Shuchi , Hill Colin S. , Zheng Lei , He Jin , Herman Joseph M. , Meyer Jeffrey , Narang Amol K.
Published: January 2022

Objective: To report on clinical outcomes and toxicity in older (age ≥ 70 years) patients with localized pancreatic cancer treated with upfront chemotherapy followed by stereotactic body radiation therapy (SBRT) with or without surgery. Methods: Endpoints included overall survival (OS), local progression-free survival (LPFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and toxicity. Results: A total of 57 older patients were included in the study. Median OS was 19.6 months, with six-month, one-year, and two-year OS rates of 83.4, 66.5, and 42.4%. On MVA, resection status (HR: 0.30, 95% CI 0.12–0.91, p = 0.031) was associated with OS. Patients with surgically resected tumors had improved median OS (29.1 vs. 7.0 months, p < 0.001). On MVA, resection status (HR: 0.40, 95% CI 0.17–0.93, p = 0.034) was also associated with PFS. Patients with surgically resected tumors had improved median PFS (12.9 vs. 1.6 months, p < 0.001). There were 3/57 cases (5.3%) of late grade 3 radiation toxicity and 2/38 cases (5.3%) of Clavien-Dindo grade 3b toxicity in those who underwent resection. Conclusion: Multimodality therapy involving SBRT is safe and feasible in older patients with localized pancreatic cancer. Surgical resection was associated with improved clinical outcomes. As such, older patients who complete chemotherapy should not be excluded from aggressive local therapy when possible.
The Influence of Low-Temperature Disintegration on the Co-Fermentation Process of Distillation Residue and Waste-Activated Sludge
Authors: Remiszewska-Skwarek Anna , Wierzchnicki Ryszard , Roubinek Otton K. , Kasinath Archana , Jeżewska Alicja , Jasinska Magdalena , Byliński Hubert , Chmielewski Andrzej G. , Czerwionka Krzysztof
Published: January 2022

Innovative low-temperature disintegration (process temperature 55 °C and oxygen concentration 0.2 mg/dm3) can be an economically rational technology to intensifying energy production from renewable sources. The proposed process can achieve a degree of disintegration—under optimal conditions—of about 50%, which is excellent when compared with other methods of feed pre-treatment. The low-temperature disintegration of distillation residue and waste-activated sludge before the co-fermentation process increased biogas production by 30% and methane production by 65% (over a 26 d duration). The obtained results confirm that the low-temperature disintegration method can be effectively used to pre-prepare this type of feed. At the same time, it was discovered that the Gompertz model can be used to mathematically describe the biogas accumulation curves in the methane co-fermentation processes of the tested feeds (the correlation coefficients were higher than 0.98).
An Analysis of Research Trends in the Sustainability of Production Planning
Authors: Khaled Mohamed Saeed , Shaban Ibrahim Abdelfadeel , Karam Ahmed , Hussain Mohamed , Zahran Ismail , Hussein Mohamed
Published: January 2022

Sustainability has become of great interest in many fields, especially in production systems due to the continual increase in the scarcity of raw materials and environmental awareness. Recent literature has given significant attention to considering the three sustainability pillars (i.e., environmental, economic, and social sustainability) in solving production planning problems. Therefore, the present study conducts a review of the literature on sustainable production planning to analyze the relationships among different production planning problems (e.g., scheduling, lot sizing, aggregate planning, etc.) and the three sustainability pillars. In addition, we analyze the identified studies based on the indicators that define each pillar. The results show that the literature most frequently addresses production scheduling problems while it lacks studies on aggregate production planning problems that consider the sustainability pillars. In addition, there is a growing trend towards obtaining integrated solutions of different planning problems, e.g., combining production planning problems with maintenance planning or energy planning. Additionally, around 45% of the identified studies considered the integration of the economic and the environmental pillars in different production planning problems. In addition, energy consumption and greenhouse gas emissions are the most frequent sustainability indicators considered in the literature, while less attention has been given to social indicators. Another issue is the low number of studies that have considered all three sustainability pillars simultaneously. The finidings highlight the need for more future research towards holistic sustainable production planning approaches.
The Effects of Using Pretreated Cotton Gin Trash on the Production of Biogas from Anaerobic Co-Digestion with Cow Manure and Sludge
Authors: Hanif Muhammad Usman , Zwawi Mohammed , Algarni Mohammed , Bahadar Ali , Iqbal Hamid , Capareda Sergio C. , Hanif Muhammad Adnan , Waqas Adeel , Hossain Nazia , Siddiqui Muhammad Tahir Hussain , Nizamuddin Sabzoi , Jamil Asma
Published: January 2022

Anaerobic co-digestion (AcoD) has been practiced for decades to convert waste into value-added energy products, especially biogas. This study aimed to assess the potential of biogenic methane (CH4) production from the co-digestion of pretreated cotton gin trash (CGT), cow manure, and sludge. CGT contains high cellulosic content, making it a reliable feedstock for biogenic methane production. To further improve the biogas quantity and quality, the CGT was subjected to physical pretreatments, i.e., hot water (HW), ultra-sonication (US), and a combination of both (HW+US). After 91 days of AcoD, 79–110 L of biogas was produced by the treatments. Among the treatments, HW+US-pretreated CGT presented maximum biogas production capacity, at 110 L. Besides, this treatment showed the high-quality biogenic CH4 content, 52.4% of the total biogas volume, with an improved conversion rate of 0.37 L/g of volatile suspended solids consumed. In addition, this study discussed the structural changes in feedstock due to pretreatments and correlated them with the corresponding biogenic methane production. The study reports the potential of pretreated CGT conversion to CH4. It will impact the circular economy by contributing to on-farm energy requirements and reducing the financial expenditures incurred in this regard.
Understanding Power Market Dynamics by Reflecting Market Interrelations and Flexibility-Oriented Bidding Strategies
Authors: Qussous Ramiz , Harder Nick , Weidlich Anke
Published: January 2022

Power markets are becoming increasingly complex as they move towards (i) integrating higher amounts of variable renewable energy, (ii) shorter trading intervals and lead times, (iii) stronger interdependencies between related markets, and (iv) increasing energy system integration. For designing them appropriately, an enhanced understanding of the dynamics in interrelated short-term physical power and energy markets is required, which can be supported by market simulations. In this paper, we present an agent-based power market simulation model with rule-based bidding strategies that addresses the above-mentioned challenges, and represents market participants individually with a high level of technical detail. By allowing agents to participate in several interrelated markets, such as the energy-only market, a procurement platform for control reserve and a local heat market representing district heating systems, cross-market opportunity costs are well reflected. With this approach, we were able to reproduce EPEX SPOT market outcomes for the German bidding zone with a high level of accuracy (mean absolute percentage error of 8 €/MWh for the years 2016–2019). We were also able to model negative market prices at the energy-only market realistically, and observed that the occurrence of negative prices differs among data inputs used. The simulation model provides a useful tool for investigating different short-term physical power/energy market structures and designs in the future. The modular structure also enables extension to further related markets, such as fuel, CO2, or derivative markets.
Potential Electricity Production by Installing Photovoltaic Systems on the Rooftops of Residential Buildings in Jordan: An Approach to Climate Change Mitigation
Authors: Monna Sameh , Abdallah Ramez , Juaidi Adel , Albatayneh Aiman , Zapata-Sierra Antonio Jesús , Manzano-Agugliaro Francisco
Published: January 2022

Countries with limited natural resources and high energy prices, such as Jordan, face significant challenges concerning energy consumption and energy efficiency, particularly in the context of climate change. Residential buildings are the most energy-consuming sector in Jordan. Photovoltaic (PV) systems on the rooftops of residential buildings can solve the problem of increasing electricity demands and address the need for more sustainable energy systems. This study calculated the potential electricity production from PV systems installed on the available rooftops of residential buildings and compared this production with current and future electricity consumption for residential households. A simulation tool using PV*SOL 2021 was used to estimate electricity production and a comparative method was used to compare electricity production and consumption. The results indicated that electricity production from PV systems installed on single houses and villas can cover, depending on the tilt angle and location of the properties, three to eight times their estimated future and current electricity use. PV installation on apartment buildings can cover 0.65 to 1.3 times their future and current electricity use. The surplus electricity produced can be used to mitigate urban energy demands and achieve energy sustainability.
Solar Energy Production in India and Commonly Used Technologies—An Overview
Authors: Pandey Aditya , Pandey Pramod , Tumuluru Jaya Shankar
Published: January 2022

This review uses a more holistic approach to provide comprehensive information and up-to-date knowledge on solar energy development in India and scientific and technological advancement. This review describes the types of solar photovoltaic (PV) systems, existing solar technologies, and the structure of PV systems. Substantial emphasis has been given to understanding the potential impacts of COVID-19 on the solar energy installed capacity. In addition, we evaluated the prospects of solar energy and the revival of growth in solar energy installation post-COVID-19. Further, we described the challenges caused by transitions and cloud enhancement on smaller and larger PV systems on the solar power amended grid-system. While the review is focused on evaluating the solar energy growth in India, we used a broader approach to compare the existing solar technologies available across the world. The need for recycling waste from solar energy systems has been emphasized. Improved PV cell efficiencies and trends in cost reductions have been provided to understand the overall growth of solar-based energy production. Further, to understand the existing technologies used in PV cell production, we have reviewed monocrystalline and polycrystalline cell structures and their limitations. In terms of solar energy production and the application of various solar technologies, we have used the latest available literature to cover stand-alone PV and on-grid PV systems. More than 5000 trillion kWh/year solar energy incidents over India are estimated, with most parts receiving 4–7 kWh/m2. Currently, energy consumption in India is about 1.13 trillion kWh/year, and production is about 1.38 trillion kWh/year, which indicates production capacities are slightly higher than actual demand. Out of a total of 100 GW of installed renewable energy capacity, the existing solar capacity in India is about 40 GW. Over the past ten years, the solar energy production capacity has increased by over 24,000%. By 2030, the total renewable energy capacity is expected to be 450 GW, and solar energy is likely to play a crucial role (over 60%). In the wake of the increased emphasis on solar energy and the substantial impacts of COVID-19 on solar energy installations, this review provides the most updated and comprehensive information on the current solar energy systems, available technologies, growth potential, prospect of solar energy, and need for growth in the solar waste recycling industry. We expect the analysis and evaluation of technologies provided here will add to the existing literature to benefit stakeholders, scientists, and policymakers.
Determination of the Most Interconnected Sections of Main Gas Pipelines Using the Maximum Clique Method
Authors: Vorobev Sergey , Kolosnitsyn Anton , Minarchenko Ilya
Published: January 2022

This article is devoted to the definition of the most important combinations of objects in critical network infrastructures. This study was carried out using the example of the Russian gas transmission network. Since natural gas is widely used in the energy sector, the gas transmission network can be exposed to terrorist threats, and the actions of intruders can be directed at both gas fields and gas pipelines. A defender–attacker model was proposed to simulate attacks. In this model, the defender solves the maximum flow problem to satisfy the needs of gas consumers. By excluding gas pipelines, the attacker tries to minimize the maximum flow in the gas transmission network. Russian and European gas transmission networks are territorially very extensive and have a significant number of mutual intersections and redundant pipelines. Therefore, one of the approaches to inflicting maximum damage on the system is modeled as an attack on a clique. A clique in this study is several interconnected objects. The article presents the list of the most interconnected sections of main gas pipelines, the failure of which can cause the greatest damage to the system in the form of a gas shortage among consumers. Conclusions were drawn about the applicability of the maximum clique method for identifying the most important objects in network critical infrastructures.
A Review of SPH Techniques for Hydrodynamic Simulations of Ocean Energy Devices
Authors: Lyu Hong-Guan , Sun Peng-Nan , Huang Xiao-Ting , Zhong Shi-Yun , Peng Yu-Xiang , Jiang Tao , Ji Chun-Ning
Published: January 2022

This article is dedicated to providing a detailed review concerning the SPH-based hydrodynamic simulations for ocean energy devices (OEDs). Attention is particularly focused on three topics that are tightly related to the concerning field, covering (1) SPH-based numerical fluid tanks, (2) multi-physics SPH techniques towards simulating OEDs, and finally (3) computational efficiency and capacity. In addition, the striking challenges of the SPH method with respect to simulating OEDs are elaborated, and the future prospects of the SPH method for the concerning topics are also provided.
A Review of Predictive and Prescriptive Offshore Wind Farm Operation and Maintenance
Authors: Fox Harriet , Pillai Ajit C. , Friedrich Daniel , Collu Maurizio , Dawood Tariq , Johanning Lars
Published: January 2022

Offshore wind farms are a rapidly developing source of clean, low-carbon energy and as they continue to grow in scale and capacity, so does the requirement for their efficient and optimised operation and maintenance. Historically, approaches to maintenance have been purely reactive. However, there is a movement in offshore wind, and wider industry in general, towards more proactive, condition-based maintenance approaches which rely on operational data-driven decision making. This paper reviews the current efforts in proactive maintenance strategies, both predictive and prescriptive, of which the latter is an evolution of the former. Both use operational data to determine whether a turbine component will fail in order to provide sufficient warning to carry out necessary maintenance. Prescriptive strategies also provide optimised maintenance actions, incorporating predictions into a wider maintenance plan to address predicted failure modes. Beginning with a summary of common techniques used across both strategies, this review moves on to discuss their respective applications in offshore wind operation and maintenance. This review concludes with suggested areas for future work, underlining the need for models which can be simply incorporated by site operators and integrate live data whilst handling uncertainties. A need for further focus on medium-term planning strategies is also highlighted along with consideration of the question of how to quantify the impact of a proactive maintenance strategy.