bluuebunny/crossref_metadata_2025 huggingface dataset:
Memotion of Fragrance
Authors: Elnissi Sharon , Rahim Muhamad Ali , Suryana Wawan
Published: March 2022

Karya yang dihadirkan menggunakan readymade object dengan teknik merakit mix-media yang dikombinasikan dengan teknik olfactory art (seni rupa penciuman), memanfaatkan Parfum wanita. Permasalahannya adalah bagaimana aroma khas dari parfum wanita yang dihadirkan dalam karya dapat mempengaruhi emosi dan/atau memori apresiator yang mencium aroma tersebut. Tujuan penelitian penciptaan ini memberikan pengalaman estetik yang dapat mempengaruhi emosi dan/atau memori apresiator karena mencium aroma khusus pada karya. Metode yang digunakan adalah studi literatur, wawancara, dan eksperimen kekaryaan. Hasil dari penelitian penciptaan ini adalah berupa delapan karya yang memvisualisasikan tujuh emosi manusia, dengan harapan, aroma pada karya dan mempengaruhi memori dan emosi apresiator.

 

The work presented uses readymade objects with a mix-media assembling technique combined with the ‘olfactory art’ technique (the art of smell), utilizing women’s perfume. The problem is how the distinctive scent of a woman’s perfume presented in the work can affect the emotions and/or memory of the appreciator who smells the scent. The purpose of this creation research is to provide an aesthetic experience that can affect the emotions and/or memory of the appreciator because it smells a special aroma in the work. The methods used are literature studies, interviews, and work experiments. The results of this creation research are in the form of eight works that visualize seven human emotions, with hope, aroma in the work and influencing the memory and emotions of the appreciator.
Nilai Karakter Pakaian Corak Tenun Songket Melayu Siak di Kampung Tengah Kabupaten Siak
Authors: Sapitri Mita , Wilson Wilson , Ayub Daeng
Published: March 2022

Bagi masyarakat Melayu selain berfungsi sebagai penutup aurat dan ciri khas, pakaian yang digunakan memiliki makna dan nilai. Begitu juga pada masyarakat Melayu Siak di Kampung Tengah,kain tenun songket khas siak yang dipakai memiliki nilai dan makna yang dipercayai oleh masyarakat di Kampung Tengah, sehingga dapat menggambarkan karakter yang menggunakannya. Tujuan penelitian ini untuk mendeskripsikan nilai karakter pada pakaian Melayu  berbagai corak tenun songket Melayu Siak yang terdiri dari pakaian harian, semi formal, formal, dan pakaian upacara pernikahan. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif dengan teknik pengumpulan data menggunakan dokumentasi, observasi dan wawancara. Hasil penelitian pada pakaian harian memiliki nilai karakter religius, disiplin dan bersahabat atau komunikatif. Pakaian semi formal memiliki nilai karakter religius, jujur, toleransi, cinta damai, peduli sosial dan tanggung jawab. Selanjutnya pada pakaian formal memiliki nilai karakter cinta damai, religius, jujur, bertanggung jawab, peduli sosial dan toleransi. Pakaian upacara pernikahan memiliki nilai karakter jujur, tanggung jawab, religious, cinta damai dan toleransi.

 

For the Malay community, clothing is used to cover the genitals and the characteristics or identity of the wearer. In addition, the clothes used have meaning and value for the Malay community. Likewise, the Siak Malay community in Kampung Tengah has a characteristic of Malay clothing by using a typical Siak songket woven cloth with various patterns or motifs that have values ​​and meanings that are believed by the people in Kampung Tengah, so that they can describe the character for those who use it. The purpose of this study is to describe the character values ​​of Malay clothing which have various styles of Siak Malay songket weaving consisting of daily, semi-formal, formal, and wedding ceremony clothes. This research uses descriptive qualitative research with data collection techniques using documentation, observation and interviews. From the research results, daily clothes have religious, disciplined and friendly or communicative character values. Semi-formal clothes have religious character values, honesty, tolerance, love of peace, social care and responsibility. Furthermore, formal clothing has character values ​​of peace-loving, religious, honest, responsible, socially caring and tolerant. Wedding ceremony clothes have character values ​​of honest, responsible, religious, peace-loving and tolerance.
Online Buying Behavior During Covid – 19 Pandemic: A Descriptive Analysis Study
Authors: Kusumastuti Retno Dyah , Maryam Siti , Kuswanti Ana , Kusuma Airlangga Surya
Published: March 2022

Since its first inception during the 1990s, electronic commerce (e-commerce) has revolutionized costumers buying behavior and caused the costumers to shift from traditional brick-and-mortar stores into online stores. In Indonesia, e-commerce market has enjoyed rapid growth around 60 to 70 percent annually since 2014. On the other hand, the Covid – 19 pandemic is still ravaging Indonesia. This pandemic caused concerns among costumers in Indonesia, due to the higher risk of Covid – 19 transmission during buying activities in traditional brick-and-mortar stores. Thus, buying from online stores became more convenient and safer option for customers. The purpose of this research is to investigate about customers online buying behavior during the Covid – 19 pandemic. This research utilized quantitative and descriptive approach, with 200 respondents participated during the survey. The findings of this research are that the majority of respondents might have shifted from offline buying to online buying, albeit not significantly. On the other hand, the majority of respondents chose to not spend a large amount of money for online buying activities. The majority of respondents also bought fashion and beauty care products from online platforms, and because of Covid – 19 pandemic, a large number of respondents also bought healhcare equipment from online platforms. The implication of this research is that it would be better if traditional brick-and-mortar retailers start transitioning to e-commerce, since customers might permanently shift to online buying, even after the Covid – 19 pandemic has been contained.
Digital Transformation and Financial Technology in Islamic Banks: A Study of Harms and Benefits
Authors: Khali̅l Sheḥadeh Maha̅
Published: March 2022

اتجهت المصارف الإسلامية في السنوات الأخيرة إلى تبني استراتيجية التحول الرقمي والتكنولوجيا المالية؛ لذا هدف هذا البحث إلى تسليط الضوء على هذه الاستراتيجية من خلال دراسة مفهوم التحول الرقمي وأبعاده، وبيان دور التكنولوجيا المالية في التحول الرقمي للصيرفة الإسلامية، بالإضافة إلى بحث مدى تحقق مقاصد الشريعة وملائمتها لاستراتيجية التحول الرقمي وصولاً إلى التأصيل الفقهي للتحول الرقمي وبيان المفاسد والمصالح والترجيح بينها. وذلك باستخدام المنهج الوصفي التحليلي، وقد خلص البحث إلى إن المصرفية الرقمية أصبحت تشكل بديلاً عصريًا للمصارف بشكلها التقليدي، ولا يمكن للمصارف أن تبقى على حالها إذا ما أرادت البقاء، بل عليها الاستعانة بالتكنولوجيا في صلب أعمالها. فلكي تستطيع البقاء في ساحة المنافسة المحلية والعالمية، فإن عليها مواكبة المستجدات من خلال مواكبة طلبات العملاء المتغيرة ومتطلبات العصر، وإلى جواز التحول الرقمي باعتباره تطويرًا لأسلوب عمل المصارف الإسلامية، واستدلت الباحثة على الجواز بعدة استدلالات من الكتاب والسنة، ومن مقاصد الشريعة. الكلمات المفتاحية: المصارف الإسلامية، التقنيات الرقمية الحديثة، التكنولوجيا المالية، التحول الرقمي.
ВІДПОВІДАЛЬНІСТЬ СУБ’ЄКТІВ УПРАВЛІННЯ ЯКІСТЮ ВИЩОЇ ОСВІТИ: АНАЛІЗ ЕКСПЕРТНИХ ОЦІНОК РОБОТОДАВЦІВ
Authors: Мороз Світлана , Мороз Володимир
Published: March 2022

Підвищення якості вищої освіти та забезпечення її тісного зв’язку з наукою передбачено стратегічним напрямом розвитку держави. Метою статті стало з’ясування думки роботодавців щодо відповідальності суб’єктів управління якістю вищої освіти за її підсумковий рівень і проведення аналізу отриманих експертних оцінок через призму проблематики вдосконалення механізмів державного управління забезпеченням якості вищої освіти. Визначення рівня відповідальності окремих з суб’єктів управління якістю вищої освіти за її підсумковий рівень стало одним з фокусів уваги проєкту «Оцінка якості вищої освіти». Використовуючи інструментарій експертного інтерв’ю та анкетування, проведено аналіз результатів опитування роботодавців і встановлено, що роботодавці не зацікавлені у залученні до процедур забезпечення якості вищої освіти та не відчувають своєї відповідальності за її підсумковий рівень. Така позиція роботодавців є цілком природною, адже участь представників реального сектора економіки у процедурах забезпечення якості вищої освіти не забезпечує отримання того економічного ефекту, який може бути здобутий суб’єктом господарювання за умови використання відповідних ресурсів у межах своєї професійної діяльності. «Неприродність процесів» забезпечення якості вищої освіти для суб’єктів господарювання стала причиною того факту, що респонденти з числа роботодавців оцінили рівень своєї відповідальності майже на мінімальному рівні. Найбільший рівень відповідальності за якість вищої освіти роботодавці поклали на заклади вищої освіти та студентів, тим самим знизивши не лише рівень своєї відповідальності, а також і відповідальності органів публічного управління та суспільства загалом. За результатами опитування роботодавців було з’ясовано їх думку щодо розподілу відповідальності за якість вищої освіти між такими її стейкхолдерами як: студенти; заклади вищої освіти; роботодавці; органи публічного управління (органи державної влади та органи місцевого самоврядування); суспільство (громадські об’єднання; моніторингові місії; експертні агентства). Результати аналізу відповідей респондентів дали змогу сформулювати узагальнення та висновки щодо можливих напрямів вдосконалення змісту та практики використання деяких з механізмів державного управління забезпеченням якості вищої освіти в частині створення умов для залучення роботодавців до процедур контролю якості результатів діяльності закладів вищої освіти. У статті обґрунтовано необхідність обов’язкового включення представників роботодавців до складу експертних груп з акредитації освітніх програм, а також до складу екзаменаційних комісій з присудження (присвоєння) професійної кваліфікації майбутнім фахівцям.
СИСТЕМА ТА СУТНІСТЬ ЗАГАЛЬНИХ ФУНКЦІЙ ДЕРЖАВНОГО УПРАВЛІННЯ У СУЧАСНИЙ ПЕРІОД
Authors: Рябець Катерина
Published: March 2022

Мета статті полягає у науково-теоретичному обґрунтуванні системи та сутності загальних функцій державного управління у сучасний період. Практична реалізація функцій державного управління здійснюється системою органів державного управління, рівень ефективності функціонування яких залежить від правильно визначеного у конкретних ситуаціях кола управлінських функцій та від розуміння їх сутності. З огляду на останнє твердження науково-теоретичне обґрунтування функцій державного управління має надзвичайну актуальність. Для досягнення мети було використано загальнонаукові та спеціальні методи дослідження. Зокрема, за допомогою: аналізу було з’ясовано зміст об’єкта та предмета дослідження; узагальнення – об’єднано науково-теоретичні положення щодо загальних функцій державного управління; абстрактно-логічного методу – проведено теоретичні узагальнення та уточнення розуміння сутності загальних функцій державного управління тощо. Досліджено теоретичні засади функцій державного управління та узагальнено їх визначення. Сформульовано авторське визначення поняття «функції державного управління» як напрями державно-управлінської діяльності, що спрямовані на досягнення цілей та виконання завдань держави. Виявлено та узагальнено погляди вітчизняних вчених на зміст системи загальних функцій державного управління. Викладено авторський підхід до складу системи загальних функцій державного управління, до якої включено: планування, організацію, аналіз, прогнозування, регулювання, координацію та контроль. Проаналізовано сутність зазначених функцій державного управління та окреслено авторське розуміння їх визначення. Зроблено висновок, що державне управління може бути успішним лише за умови реалізації сукупності загальних функцій. Одним із напрямів подальших досліджень визначено здійснення порівняльного аналізу співвідношення загальних і спеціальних функцій державного управління.
УДОСКОНАЛЕННЯ СИСТЕМИ ЦИВІЛЬНОГО ЗАХИСТУ ТЕРИТОРІАЛЬНИХ ГРОМАД ЯК ЗАПОРУКА ПІДВИЩЕННЯ РІВНЯ СПРОМОЖНОСТЕЙ ЄДИНОЇ ДЕРЖАВНОЇ СИСТЕМИ ЦИВІЛЬНОГО ЗАХИСТУ
Authors: Коробкін Валерій , Яковлєва Ярослава
Published: March 2022

У процесі здійснення заходів Концепції реформування місцевого самоврядування важливим є конкретизація задач і вимог реалізації завдань цивільного захисту на рівні територіальних громад. Тому метою статті є формулювання напрямів із внесення змін / доповнень до нормативно-правових актів з питань організації системи цивільного захисту на рівні місцевого самоврядування та визначення заходів з удосконалення цивільного захисту територіальних громад. Об’єкт дослідження – функціонування системи цивільного захисту в територіальних громадах. Обґрунтовано доцільність змін до статей 6, 25, 30, 35, 36, 37 Кодексу цивільного захисту України в частині упорядкування повноважень сільських, селищних, міських рад, їх виконавчих органів, розмежування повноважень рад, конкретизації діяльності сільських, селищних і міських територіальних громад як суб’єктів забезпечення цивільного захисту. Для удосконалення діяльності територіальних громад у сфері цивільного захисту запропоновано напрями змін до нормативних актів Кабінету Міністрів України в частині визначення ролі органів місцевого самоврядування сільських, селищних і міських рад як суб’єктів забезпечення цивільного захисту, конкретизації створення ланки територіальної підсистеми єдиної державної системи цивільного захисту в територіальній громаді з переліком служб та їх завдань (в межах області, району, громади), ролі та права територіальної громади в залученні відповідних служб. Наголошено на впровадженні досвіду організації системи цивільного захисту муніципалітетів Канади, де місцеві муніципалітети відіграють ключову роль в підвищенні стійкості суспільства до надзвичайних ситуацій, беруть на себе ряд обов’язків щодо захисту цивільного населення. Складовою частиною роботи є пропозиції щодо першочергових завдань і кроків з організації цивільного захисту на базовому рівні місцевого самоврядування, які запропоновані як пояснення законодавчих і нормативно-правових актів з питань цивільного захисту, алгоритми дій керівників (фахівців) органів місцевого самоврядування, стосовно організації та здійснення заходів ЦЗ на території громади, а також як типові та формалізовані документи (варіанти рішень ради громади, виконавчого органу громади, розпоряджень голови громади).
PROGRAM HAFALAN TAKHASUS DI SDIT AL RAHBINI GONDANGLEGI DALAM MEMBANGUN KARAKTER ISLAMI DI LINGKUNGAN SEKOLAH
Authors: Habibah Ilun Lailatul , Assyahrunnizam Muh , Salim Muhammad Nur
Published: March 2022

Artikel ini membahas tentang penanaman karakter Islami yang dilakukan melalui program hafalan takhasus di SDIT AL Rahbini Gondanglegi. Studi ini dilatarbelakangi oleh kemunduran karakter yang cenderung ke arah negatif, seiring dengan perkembangan zaman dan teknologi. Melihat kondisi yang demikian, sangat diperlukan upaya untuk menanamkan karakter Islami kepada anak sejak dini. Penelitian ini menggunakan pendekatan penelitian kualitatif. Jenis penelitian kualitatif yang digunakan adalah penelitian kualitataif deskriptif. Tujuan penelitian deskriptif dalam penelitian ini adalah mendeskripsikan upaya penanaman karakter Islami melalui pelaksanaan program hafalan takhasus di SDIT AL Rahbini Gondanglegi. Untuk memperoleh data yang valid, dalam penelitian ini diperlukan pengumpulan data dengan menggunakan tiga metode yaitu, wawancara, observasi, dan dokumentasi.Penelitian ini menggunakan analisis data dengan verifikasi terhadap data yang telah terkumpul. Verifikasi tersebut dilakukan dengan metode triangulasi. Penanaman karakter Islami dilakukan dengan berbagai metode, yakni metode penyampaian, pembiasaan, keteladanan, teguran, dan pemberian reward dan punishment. Nilai-nilai karakter Islami yang dapat ditanamkan meliputi karakter religius atau Islami, jujur, rajin, kerja keras, tanggung jawab, gemar membaca, disiplin, mandiri, dan peduli sosial. Program hafalan takhasus meliputi hafalan al-Qur׳ān (juz ‘amma atau juz 30), hafalan al-Ḥadῑṡ yang sahih dan masyhur, dan doa-doa harian. Program ini dilaksanakan setiap hari, mulai Selasa hingga Sabtu, pada setiap 35 menit jam pertama. Hafalan tiga komponen di atas dilaksanakan dengan cara membaca dan menirukan secara berulang-ulang. Sekian banyak hafalan yang menjadi tanggung jawab peserta didik, disusun secara berjenjang, dibagi-bagi dalam enam kelas. Jadi masing-masing kelas memiliki materi hafalan yang berbeda-beda, namun bersifat kontinuitas.
PENGEMBANGAN BAHAN BELAJAR MANDIRI UNTUK MENINGKATKAN HASIL PEMBELAJARAN TEMATIK DI KELAS III
Authors: Ulfa Nanik , Hidayatullah Moh Rizki
Published: March 2022

Penelitian ini dilatarbelakangi oleh kurangnya pemahaman tentang materi manfaat tumbuhan bagi kehidupan manusia yang disampaikan secara daring yang membuat siswa bingung saat menyelesaikan soal terkait materi manfaat tumbuhan bagi kehidupan manusia. Siswa juga belum dilibatkan secara maksimal dalam pembelajaran sehingga belajar yang didapat tidak maksimal. Jenis penelitian yang digunakan penulis adalah metode penelitian Research and Development (R&D), dimana penelitian ini menghasilkan sebuah produk tertentu dan menguji kelayakan serta keefektifan produk yang dikembangkan. Metode penelitian ini menggunakan model pengembangan 4D. Teknik pengumpulan data yang dilakukan oleh peneliti menggunakan angket/ lembar validasi. Hasil penelitian ini telah menghasilkan produk media pembelajaran berupa media bahan belajar mandiri. Dari hasil bahan belajar mandiri yang telah dikembangkan telah diuji kelayakan produk oleh ahli materi dan desain. Berdasarkan hasil validasi materi menunjukkan bahan belajar mandiri memiliki tingkat kelayakan 98,07% yang termasuk dalam kualifikasi “sangat layak”. Hasil validasi desain menunjukkan bahan belajar mandiri memiliki tingkat kelayakan 93,3% yang termasuk dalam kualifikasi “sangat layak”. Hasil uji coba skala sedang dilakukan kepada 15 siswa dengan memperoleh presentase siswa 98,33% Sehingga bahan belajar mandiri dinyatakan sangat dibutuhkan untuk meningkatkanhasil belajar siswa, dan sangat berkontribusi sebagai penunjang pembelajaran.
Efektivitas Ampas Tahu Sebagai Adsorben Logam Tembaga Pada Air Limbah Industri
Authors: Indah Dahlia Rosma , Hatimah Husnul , Hulyadi Hulyadi
Published: March 2022

Copper is one of the toxic metals for health and the environment. In humans, high doses of copper metal can cause vomiting, dizziness, weakness, kidney and liver symptoms, anemia, to coma, and in severe cases, the patient can die. Judging from the dangers, proper waste management is needed to reduce the side effects of these pollutants. A practical and inexpensive technology is an adsorption adsorption technique using an efficient and easily available natural adsorbent, namely tofu dregs. The protein contained in tofu is one of the reasons for using tofu waste as an adsorbent. The absorption of amino acids that form two-charged ions (zwitter ions) is owned by proteins. Toxic metal can be bound to protein as metallotionein. The study consisted of four stages, namely (1) Analysis of initial copper content in silver craft waste; (2) Preparation of tofu waste adsorbent; (3) Characterization of tofu dregs adsorbent; and (4) variation of adsorption contact time. The study used a laboratory-scale experimental method. The adsorbent was contacted with the sample using a magnetic stirrer at various times. Instrument Atomic Absorption Spectrometer was used for the analysis of copper metal content and identification of its functional groups using an infrared spectrometer with the result that tofu waste has functional groups -OH, NH (stretching), CH (aliphatic), C=O, -OH (bending vibrations). , and CO. Copper metal content obtained is 19.5979 ppm. The optimum adsorption time was reached at 120 minutes with an optimum adsorption efficiency of 54.88%.
Tactile Rendering of Textile Materials
Authors: Periyaswamy Thamizhisai
Published: March 2022

Tactile rendering attempts to replicate touch stimuli with the aid of haptic devices so that the perception of a material can be stored and transmitted to a remote user. Haptic devices have potential implications on prosthetics, rehabilitation, telemedicine, and virtual reality. Research on haptic interfaces and novel approaches to rendering tactile feedback in virtual and immersive environments has grown recently. We conducted a comprehensive analysis to obtain information on tactile rendering, in general, from scholarly works published between 2009 and 2019. We present a consolidated report on the current techniques on tactile rendering of textile materials. Existing research on tactile rendering focused on three significant areas: surface feature extraction, virtual texture simulation, and assessment by a human observer. We found that in the majority of the cases, the tactile interface system uses a mechatronics framework, where one or more electromechanical transducers converted tiny electrical signals into mechanical forces to generate the necessary haptic stimuli. Furthermore, the paper discusses the prevailing critical challenges in tactile rendering and the directions for future research.
Economic efficiency of growing oreganum vulgare (Origanum vulgare L.) by seedling method of reproduction in conditions of drop irrigation
Authors: Privedenyuk N.
Published: March 2022

A study was conducted to establish the effect of different planting densities of oregano plants on its yield under drip irrigation. The economic estimation of the developed technologies of cultivation is executed. The profitability of crop production in the first and second year of cultivation was calculated. It is established that the economic indicators in the first year of growing oregano are not high, due to the low yield of dry raw materials — a biological feature of the culture. In the second year of growing oregano, the yield of dry raw materials was much higher, as a result, economic indicators were quite high, the profitability of production ranged from 162.1 to 264.4%. Based on the analysis of the cost structure, the factors that most significantly affect the cost of raw materials are identified. The high efficiency of the seedling method of growing oregano under conditions of drip irrigation has been proved.
Economic tools of providing a balanced development of berry growing
Authors: Koval A.
Published: March 2022

In the article the modern state of berry growing in Ukraine is analyzed. The mechanism of the government regulation of Ukrainian economy in berry growing field is presented. The economic approaches to providing balanced development of berry growing in Ukraine are described. The climate, nature, economic, social-demographic and other conditions which influence berry growing area are taken into consideration in terms of perspective development. The systematization of eco-economic tools of balanced development of berry growing is presented, in particular: ecological insurance, ecological management, ecological marketing, ’ecological’ certificates, ecological charges and fines, trade permission on pollution, subsidies on ecology, ecological taxes and ecological audit. It was discovered that economic tools of providing a balanced development of berry growing are the components which enable to provide a balance attitude to the development of the field, save the environment and enhance the Ukrainian economy. It was stated that the mechanism of the government regulation in this field needs to be improved taken into account modern ways of management and the market demand. The economic and ecological tools of a balanced development were highlighted as they should be aimed at stimulating and support of all subjects in this field in order to create favorable conditions for successful activity.
Academia versus prensa. La Real Academia Española y los libros de estilo de ABC (1993, 2001), El Mundo (1996) y La Vanguardia (2005): análisis del léxico
Authors: Díaz Rosales Raúl
Published: March 2022

Academia versus prensa. La Real Academia Española y los libros de estilo de ABC (1993, 2001), El Mundo (1996) y La Vanguardia (2005): análisis del léxico
Development of a Fluorescent Microfluidic Device Based on Antibody Microarray Read-Out for Therapeutic Drug Monitoring of Acenocoumarol
Authors: Salvador J.-Pablo , Brettschneider Thomas , Dorrer Christian , Marco M.-Pilar
Published: March 2022

The development of a proof-of-concept point-of-care (PoC) device for the determination of oral anticoagulants determination is presented. Acenocoumarol (ACL) is prescribed to prevent certain cardiovascular diseases related to the prevention of deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Oral anticoagualant treatment (OAT) represents a population of 2% under treatment which has expenditures about $ 144 million in 2011. The main drawback for OAT is the associated narrow therapeutic window and the unpredictable dose-response relationship, which is one of the main causes for visiting the emergency room at the hospitals. In a previous work, family antibodies were produced for the simultaneous detection of ACL and warfarin (W) depending on the area of application. It was developed in different formats, indirect and direct, either with similar detectabilities and both assays quantifying the oral anticoagulants with high accuracy and reproducibility. We present the implementation of the already developed immunochemical method to a point-of-care (PoC) device to assist on the patient compliance assessment programs. In order to achieve this goal, a first development was performed implementing ACL ELISA assay into a microarray format with fluorescent read-out. The assay was successfully implemented achieving a LOD of 1.23 nM of ACL directly measured in human plasma. Then, a fully integrated microfluidic system is developed which incorporates the specific immunoreagents for the detection of ACL. The immunoreagents were attached onto the glass slide in a microarray format. The system is automatic, rapid, sensitive, and disposable that could help clinicians monitor patients under OAT. According to the fluorescent label of the ACL binding, the chip can be easily read with a scanner. The microfluidic system performed good according to the robust and reproducible signals, and subsequently yielded an accurate result.
An Appraisal Among Wired, Hybrid and Wireless Smart Homes to Mitigate Electromagnetic Radiation
Authors: Raveendran Reshna , Tabet Aoul Kheira Anissa
Published: March 2022

The global Covid-19 pandemic caused a rapid transitioning to remote work settings, one likely to linger post-pandemic, resulting on people spending more time at home for work or study. The globalpandemic defined a new normal that is expected to be digital and heavily relying on technology. Smart buildings which are envisioned to be the next paradigm shift in the built environment are also foreseen as a response solution to aid in situations like pandemic. However, such a move yields benefits as well as risks, prompting wide debates on the priority to safeguard building occupants health, safety and well-being. Researchers, designers and engineers are seeking solutions to incorporate or modify design features in the indoor environment that prioritize the dwellers’ health and wellness. Though benefits of smart and IoT devices aid in monitoring health and wellness, radiation from these wireless devices may cause harm to human health, especially those with weaker health, as indicated by several research findings. Some of the negative impacts from wireless radiation include cell damage, cancer, tumor, change in hormonal levels, and neurological damage. Thus, this study seeks to determine the difference in radiation level inside a wired, hybrid and a wireless smart home through Computer Simulation Technology (CST) simulation. Such a quantification can help designers develop strategies to design smart buildings that cause low radiation for its occupants. Antenna field source was imported to CST to create the wireless and hybrid design scenario. The measurement for wired and hybrid were evaluated keeping the wired design as baseline. The results revealed that wireless produced 26.55% more radiation than wired scenario at 2.45 GHz, taken as baseline measurement. Further, the total Electromagnetic Radiation (EMR) and radiation patterns are dependent on several factors like proximity of IoT and smart devices to building walls and interior furnishings, frequency of operation. In order to create a safer indoor environment, this study recommends the use of both wired and hybrid design in lieu of totally wireless smart buildings.
Regulation of Pyroptosis by ncRNA: A Novel Research Direction
Authors: Gao Liyuan , Jiang Zhitao , Han Yi , Li Yang , Yang Xiang
Published: March 2022

Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents. The process of pyroptosis is performed by certain inflammasome and executor gasdermin family member. Previous researches have manifested that pyroptosis is closely related to human diseases (such as inflammatory diseases) and malignant tumors, while the regulation mechanism of pyroptosis is not yet clear. Non-coding RNA (ncRNA) such as microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA) have been widely identified in the genome of eukaryotes and played a paramount role in the development of cell function and fate after transcription. Accumulating evidences support the importance of ncRNA biology in the hallmarks of pyroptosis. However, the associations between ncRNA and pyroptosis are rarely reviewed. In this review, we are trying to summarize the regulation and function of ncRNA in cell pyroptosis, which provides a new research direction and ideas for the study of pyroptosis in different diseases.
Combining Dynamical and Statistical Modeling to Improve the Prediction of Surface Air Temperatures 2 Months in Advance: A Hybrid Approach
Authors: Oettli Pascal , Nonaka Masami , Richter Ingo , Koshiba Hiroyuki , Tokiya Yosuke , Hoshino Itsumi , Behera Swadhin K.
Published: March 2022

A new type of hybrid prediction system (HPS) of the land surface air temperature (SAT) is described and its skill evaluated for one particular application. This approach utilizes sea-surface temperatures (SST) forecast by a dynamical prediction system, SINTEX-F2, to provide predictors of the SAT to a statistical modeling system consisting of a set of nine different machine learning algorithms. The statistical component is aimed to restore teleconnections between SST and SAT, particularly in the mid-latitudes, which are generally not captured well in the dynamical prediction system. The HPS is used to predict the SAT in the central region of Japan around Tokyo (Kantō) as a case study. Results show that at 2-month lead the hybrid model outperforms both persistence and the SINTEX-F2 prediction of SAT. This is also true when prediction skill is assessed for each calendar month separately. Despite the model's strong performance, there are also some limitations. The limited sample size makes it more difficult to calibrate the statistical model and to reliably evaluate its skill.
Nonmetallic Mineral as the Carrier of TiO2 Photocatalyst: A Review
Authors: Xie Yan , Wang Jiao , Ren Fengguo , Shuai Huan , Du Gaoxiang
Published: March 2022

The composite photocatalyst can be constructed by using natural porous minerals with a wide range of sources, low prices and stable chemical properties as the titanium dioxide catalyst carrier, which can not only reduce the cost of catalyst preparation and application, but also effectively improve the dispersion, recyclability and catalytic performance of the catalyst. In recent years, a large number of scientific researchers have conducted a lot of research on the preparation and performance of porous mineral-supported composite catalytic materials. This paper describes the catalytic mechanism of titanium dioxide, as well as the research and application progress of various nonmetallic mineral materials supported by titanium dioxide, and prospects the development trend in the future.
Patient Prosthesis Mismatch After SAVR and TAVR
Authors: Bleiziffer Sabine , Rudolph Tanja K.
Published: March 2022

Patient-prosthesis mismatch (PPM) remains one out of many factors to be considered during decision-making for the treatment of aortic valve pathologies. The idea of adequate sizing of a prosthetic heart valve was established by Rahimtoola already in 1978. In this article, the author described the phenomenon that the orifice area of a prosthetic heart valve may be too small for the individual patient. PPM is assessed by measurement or projection of the prosthetic effective orifice area indexed to body surface area (iEOA), while it is recommended to use different cut point values for non-obese and obese patients for the categorization of moderate and severe PPM. Several factors influence the accuracy of both the projected and the measured iEOA for PPM assessment, which leads to a certain number of false assignments to the PPM or no PPM group. Despite divergent findings on the impact of PPM on clinical outcomes, there is consensus that PPM should be avoided to prevent sequelae of increased prosthetic gradients after aortic valve replacement. To prevent PPM, it is required to anticipate the iEOA of the prosthesis prior to the procedure. The use of adequate reference tables, derived from echocardiographically measured mean effective orifice area (EOA) values from preferably large numbers of patients, is most appropriate to predict the iEOA. Such tables should be used also for transcatheter heart valves in the future. During the decision-making process, all available options should be taken into account for the individual patient. If the predicted size and type of a surgical prosthesis cannot be implanted, additional surgical procedures, such as annular enlargement with the Manougian technique, or alternative procedures, such as transcatheter aortic valve implantation (TAVI) can prevent PPM. PPM prevention for TAVI patients is a new field of interest and includes anticipation of the iEOA, prosthesis selection, and procedural strategies.
Surgical Restoration of Antero-Apical Left Ventricular Aneurysms: Cardiac Computed Tomography for Therapy Planning
Authors: Solowjowa Natalia , Nemchyna Olena , Hrytsyna Yuriy , Meyer Alexander , Hennig Felix , Falk Volkmar , Knosalla Christoph
Published: March 2022

Background

Surgical ventricular restoration (SVR) leads to functional improvement by volume reduction and restoration of left ventricular (LV) geometry. Our purpose was to refine the planning for SVR using cardiac computed tomography (CCT).

Methods

The possibility to anticipate the postoperative residual LV volume was assessed using CCT in 205 patients undergoing SVR combined with coronary artery bypass grafting (77%), mitral valve repair/replacement (19%) and LV thrombectomy (19%). The potential of CCT to guide the procedure was evaluated. Additionally, the predictive value of CCT characteristics on survival was addressed.

Results

30-day, 1- and 5-year survival was 92.6, 82.7, and 72.1%, respectively, with a marked reduction of NYHA class III-IV quota after surgery (95.1% vs. 20.5% in the follow-up). Both pre- and postoperative LV end-systolic volume index (LVESVI) were predictive of all defined endpoints according to the following tertiles: preoperative: <74 ml/m2, 74–114 ml/m2 and >114 ml/m2; postoperative: <58 ml/m2, 58–82 ml/m2 and >82 ml/m2. On average, a 50 ml/m2 increase of preoperative LVESVI was associated with a 35% higher hazard of death (p = 0.043). Aneurysms limited to seven antero-apical segments (1–7) were associated with a lower death risk (n = 60, HR 0.52, CI 0.28–0.96, p = 0.038). LVESVI predicted by CCT was found to correlate significantly with effectively achieved LVESVI (r = 0.87 and r = 0.88, respectively, p < 0.0001).

Conclusions

CCT-guided SVR can be performed with good mid-term survival and significant improvement in HF severity. CCT-based assessment of achievable postoperative LV volume helps estimate the probability of therapeutic success in individual patients.
Fit, Female or Fifty–Is Cardiac Rehabilitation “Fit” for Purpose for All? A Systematic Review and Meta-Analysis With Meta-Regression
Authors: Smith Martin , Orchard Jessica , La Gerche Andre , Gallagher Robyn , Fitzpatrick Jane
Published: March 2022

Aims

Cardiac rehabilitation (CR) is an evidence-based intervention promoting risk factor modification following coronary artery disease events but the relative benefits for patient subgroups is not clear. This review synthesizes the available evidence on the effectiveness of modern CR programs and determines outcomes for age, sex and prior level of fitness.

Methods

MEDLINE, CINAHL, and EMBASE were examined for RCT and cohort studies involving exercise prescription or phase II or III CR following Myocardial Infarction (MI), Percutaneous Coronary Intervention (PCI) and cardiac surgery from January 2010 to February 2021. Outcomes assessed included peakVO2max, 6-min walk test and Metabolic Equivalent of Task. Meta-regression was used to determine CR impact for change in fitness and age and sex influences.

Results

The mean age of study participants was 59.5 years and 82.7% were male. Females, younger people and those of average or above cardiorespiratory fitness were substantially under-represented in data and attendance, with 13% of study groups with a mean age <55 years. At entry, 73% were below average for fitness vs. age-matched normative values. Fitness improved across all groups following CR with no evidence of sex or age independently affecting outcomes.

Conclusions

Modest improvements in fitness in all groups were shown, but the benefits of CR can be far greater. A modern, innovative approach to CR will likely lead to more substantial benefits. This may require a “Precision Medicine” model which tailors exercise prescription to different populations to ensure all CR participant's needs are met. This will ensure that CR is more flexible and accessible for all.
MLS-Based Numerical Manifold Method for Modeling the Cracked Rock Considering the Contact of the Crack Surface
Authors: Li Wei , Zheng Hong , Yu Xianbin , Jia Chuanyang , Sun Xizhen
Published: March 2022

To simulate the moving boundary problems, the moving least square–based numerical manifold method, abbreviated as MLS-based NMM, was proposed. The MLS-based NMM has been applied successfully to open crack problems, which exhibits the high accuracy and strong robustness. In this study, we extend the MLS-based NMM to simulate the cracked rock considering the contact of the crack surface. Simultaneously, in order to simulate the progressive failure of the cracked rock, an improved strength-based criterion is proposed. The criterion is based on the Mohr–Coulomb criterion and maximum tensile stress criterion. Because rock can be regarded as a quasi-brittle material, a characteristic distance is used to calculate the crack tip stress and correct the crack propagation direction which avoids the phenomenon of “Zig-zag” for the crack propagation path based on the fracture mechanics criterion. The proposed strength-based criterion can acquire the crack tip stress and propagation direction and also realize the automatic determination of the crack propagation length in each step of the crack growth. A Brazilian disc problem and a rectangular plate problem are adopted to verify the numerical model. At last, the numerical model is applied to study the progressive failure process of the rock slope. The results indicate that the proposed method can deal with the crack propagation in the rock and the opening/sliding of rock blocks along discontinuities in a natural way.
Kinetic Energy and Vorticity Perspectives of the Rapid Development of an Explosive Extratropical Cyclone Over the Northwest Pacific Ocean in February 2018
Authors: Wang Hui , Du Mengjiao , Sun Chenghu , Zhang Bo
Published: March 2022

Explosive extratropical cyclones (EECs) have long been a research focus for the meteorological society as they often cause serious economic losses and casualties. However, after a long period of research, there still remain some knowledge gaps about their rapid development. In this article, we conducted the first study by using both vorticity and kinetic energy (KE) budgets simultaneously on a typical EEC, which was the strongest EEC that affected the coastal areas of China in the last 3 years, to further the understanding of the mechanisms governing its rapid enhancement in rotation and wind speed. The vorticity budget shows that the lower-level convergence-related vertical stretching and the vertical transport of vorticity acted as the most and second most favorable factors for the increase in the cyclone's cyclonic vorticity, respectively, which were different from those findings based on the Zwack–Okossi vorticity budget. In contrast, the horizontal transport of vorticity and tilting mainly decelerated the EEC's development. Energetics features governing the rapid wind enhancement of the EEC were shown for the first time. It is found that the work on the rotational wind by the pressure gradient force and the net import transport of KE by the rotational wind contributed the largest and second largest to the cyclone's increase in wind speed. In contrast, the upward transport of KE and the cyclone's displacement mainly acted in an opposite way. Analysis based on the Green's theorem and rotational wind shows that the enhancement of the EEC's rotation and wind speed were linked to each other solidly.
Geometry of the Magma Chamber and Curie Point Depth Beneath Hawaii Island: Inferences From Magnetic and Gravity Data
Authors: Mohamed Ahmed , Al Deep Mohamed , Abdelrahman Kamal , Abdelrady Ahmed
Published: March 2022

This study used land gravity and airborne magnetic data to investigate the depth to the magmatic chamber and map the heat flow distribution beneath the active volcanoes of Hawaii Island using the Curie point depth (CPD) and gravity modeling. Obtaining some of the ground-based geophysical measurements was problematic due to accessibility limitations; therefore, this study used available data. The CPD and magnetic data were used to map the depth to the bottom of the magnetic layer by calculating the depth to the Curie isotherm (540°C) beneath Hawaii Island. The spectral peak method was used to calculate the depths to the shallow and deep magnetic sources for the entire island, and the CPD was calculated using the centroid method. A two-dimensional density model for two Earth layers was constructed using forward modeling of the gravity data. A large plume of dense intrusive material was observed beneath the three adjacent volcanoes of Mauna Loa, Mauna Kea, and Kilauea, and two small chambers were found to be located beneath the Kohala and Hualalai volcanoes. Based on the gravity modeling results, the depth to the magma layer varied from 0.5 to 10 km, and the heat flow was higher close to the volcanic eruption zones. The current study is informative and cost effective for the world’s most active volcanic areas.
Accelerated Ovarian Aging Among Type 2 Diabetes Patients and Its Association With Adverse Lipid Profile
Authors: Wang Yahao , Wang Yangang
Published: March 2022

Background

The impact of diabetes on reproductive function is still not clearly defined. This study aimed to evaluate accelerated ovarian aging in women with type 2 diabetes mellitus (T2DM) and its association with adverse lipid profile.

Methods

Female patients with T2DM (n=964) and non-T2DM controls (n=263) aging from 18-80 years were included. Levels of circulating sex hormones were measured at the follicular phase in menstruating women. We analyzed the age-specific trends in the levels of sex hormones between T2DM and controls. The correlations of sex hormones with the lipid profile, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG) were also evaluated.

Results

In the temporal trends analysis, LH and FSH both started to increase obviously approximately from the age of 45 years among patients with T2DM, and displayed peaks of LH and FSH among patients with T2DM aged between 61 and 65, both of which were obviously earlier than that in non-T2DM controls and proved the accelerated ovarian aging among patients with T2DM. E2 of patients with T2DM was continuous lower than that of non-T2DM controls from approximately 45 years old, and LH and FSH of patients with T2DM were higher than those of non-T2DM controls between the age of 55 to 65 years. Multiple linear regression analyses revealed that LH was positively correlated with LDL-C (Coefficient=0.156, P=0.001) and TC (Coefficient=0.134, P=0.025), and was negatively correlated with HDL-C (Coefficient =-0.065, P=0.001) in patients with T2DM aged between 51 and 60, which was independent of age, T2DM duration, body mass index (BMI), glycosylated hemoglobin (HbA1c), FSH, E2 and other potential confounders. Higher E2 level was significantly and independently correlated with lower LDL-C (Coefficient= -0.064, P=0.033) in patients with T2DM aged between 51 and 60.

Conclusions

This study suggests that patients with T2DM have accelerated ovarian aging, and it is correlated with the occurrence of disturbed lipid profile in patients with T2DM. With an ever increasing number of female patients with T2DM diagnosed at younger ages, the accelerated ovarian aging and its adverse impacts in T2DM need to be carefully managed.
Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications
Authors: Yang Xi-Ding , Yang Yong-Yu
Published: March 2022

The global diabetes epidemic and its complications are increasing, thereby posing a major threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its complications is necessary for the development of effective treatments. Ferroptosis is a newly identified form of programmed cell death caused by the production of reactive oxygen species and an imbalance in iron homeostasis. Increasing evidence suggests that ferroptosis plays a pivotal role in the pathogenesis of diabetes and diabetes-related complications. In this review, we summarize the potential impact and regulatory mechanisms of ferroptosis on diabetes and its complications, as well as inhibitors of ferroptosis in diabetes and diabetic complications. Therefore, understanding the regulatory mechanisms of ferroptosis and developing drugs or agents that target ferroptosis may provide new treatment strategies for patients with diabetes.
Using Metabarcoding to Investigate the Strength of Plant-Pollinator Interactions From Surveys of Visits to DNA Sequences
Authors: Baksay Sandra , Andalo Christophe , Galop Didier , Burrus Monique , Escaravage Nathalie , Pornon André
Published: March 2022

The ongoing decline in pollinators and increasing concerns about pollination services require a better understanding of complex pollination networks, particularly their response to global climate change. While metabarcoding is increasingly used for the identification of taxa in DNA mixtures, its reliability in providing quantitative information on plant-pollinator interactions is still the subject of debate. Combining metabarcoding and microscopy, we investigated the relationships between the number and composition of sequences and the abundance and composition of pollen in insect pollen loads (IPL) and how the two are linked to insect visits. Our findings confirm that metabarcoding is more effective than microscopy in identifying plant species in IPL. For a given species, we found a strong positive relationship between the amount of pollen in IPL and the number of sequences. The relationship was stable across species even if the abundance of co-occurring species in IPL (hereafter “co-occurring pollen”) tended to reduce the sequence yield (number of sequences obtained from one pollen grain) of a given species. We also found a positive relationship between the sequence count and the frequency of visits, and between the frequency and the amounts of pollen in IPL. Our results demonstrate the reliability of metabarcoding in assessing the strength of plant-pollinator interactions and in providing a broader perspective for the analyses of plant-pollinator interactions and pollination networks.