bluuebunny/crossref_metadata_2025 huggingface dataset:
The Main Features of the Administrative Law of the Moscow State in the 16th Century (Part 2)
Authors:   Professor of the Department of Civil and Administrative Procedure of the Volga-Vyatka Institute (Branch) of the Kutafin Moscow State Law University (MSAL), LL.D., Professor, Kononov Pavel I.
Published: January 2024

The article gives general characteristics of tendencies in the development of the administrative law regulation of social relations in the Moscow State during the 16th century, classifies administrative law sources of that period, studies their content. The author states that the main administrative law sources in the first half of the 16th century were charters of the viceroy’s administration, and in the second half, provincial and zemstvo charters, the Codes of Laws of 1550 and 1589, some tsar’s charters of the administrative permissive and administrative protective (police) nature. The paper analyzes administrative law provisions contained in the mentioned laws and regulations.
On Challenging Aspects of Exercising the Prosecutor’s Powers in Administrative Offense Proceedings
Authors:   Lecturer of the Department of Administrative Law and Administrative Activities of Internal Affairs Agencies of the Ural Law Institute of the Ministry of the Interior of Russia, Police Lieutenant, Koshelev Dmitry A.
Published: January 2024

This article examines the issues of implementation by the prosecutor of powers in administrative proceedings. Attention is focused on expanding and clarifying the powers of the prosecutor, which will improve the efficiency and quality of response in order to resolve issues of administrative responsibility and effectively protect violated public interests.
Safety assessment and determination of a maximally tolerated dose of an RAS-GTPase inhibitor (iRAS) in the treatment of gastrointestinal tumors: preliminary results of the phase I trial
Authors: Bozhenko Vladimir K. , Goncharov Sergey V. , Kudinova Elena A. , Kulinich Tatiana M. , Kukoleva Elena A. , Filippov Mikhail S. , Bykova Anna F. , Knyazeva Oksana B. , Puchkov Ilya A. , Solodkiy Vladimir A.
Published: January 2024

Background: Ras oncogene mutations leading to hyperactivation of the MAPK/ERK signaling pathway occur in 25% of all human tumors, and for gastrointestinal tumors, the frequency of Ras mutations amounts to 60%. The introduction of a Ras-GTPase inhibitor into clinical practice would increase the effectiveness of the treatment of socially significant diseases such as stomach and intestinal cancer.
Aim: To select the optimal dose with a subsequent assessment of the safety of iRAS when administered to patients with gastrointestinal tract tumors, including those with peritoneal carcinomatosis.
Materials and methods: This was a prospective open-label non-randomized phase I study for the assessment of safety and tolerability, with an adaptive design and determination of the maximally tolerated dose of the iRAS. Three dose levels were used (0.45 mg/kg, 0.9 mg/kg, 1.8 mg/kg) according to the "3 + 3" scheme. The study included 11 patients after surgery for stomach or colorectal cancer. The patients were administered PIPAC therapy with iRAS twice with a 7-days interval. The study duration was 28 ± 1 days. During the study, the patient monitoring included physical examination, assessment of vital signs, electrocardiography and echocardiography, laboratory parameters (hematology, clinical chemistry, coagulation tests, and urine analysis).
Results: The anti-tumor iRAS agent demonstrated satisfactory tolerability of all doses studied, including the maximal 1.8 mg/kg dose. Vital sign and laboratory abnormalities were clinically non-significant and did not require additional therapeutic interventions. Statistically significant abnormalities were registered for total protein (p = 0.00028), white blood cell counts (p = 0.007), lymphocyte counts (p = 0.0008), and a number of other blood parameters; however, most of these abnormalities were within the physiological normal ranges. Vital signs such as electrocardiography and echocardiography parameters remained stable throughout the entire follow-up period (28 days after administration of the drug). There were short-term rises in body temperature, minor pains in the postoperative scar area.
Conclusion: This trial of safety and tolerability of iRAS showed that no cases of dose-limiting toxicity in the studied dose range. The 1.8 mg/kg dose can be recommended for further clinical studies.
Inmigración en Latinoamérica en democracias con Alzheimer
Authors: Abedrapo Jaime
Published: January 2024

Las democracias liberales en los tiempos de la posmodernidad enfrentan retos tales como el cambio climático, el acceso fuentes de energía renovables y no contaminantes y la inmigración. Al respecto, observaremos las tendencias para abordar estos asuntos, con un especial foco en Latinoamérica y la inmigración.La crisis civilizacional a la que asistimos tiende a olvidar sus orígenes culturales, por tanto, su legitimidad sustentada en las normas que fundamentaron el orden mundial de Post Segunda Guerra Mundial, cuestión que hemos entendido como una afectación del alzhéimer, el que precisamente evita que los fenómenos inmigratorios sean abordados desde sus causas.
El consentimiento estatal en el spotlight: un análisis actual de su naturaleza jurídica, su aplicación a la justicia internacional y la importancia que reviste para el derecho internacional
Authors: De Trazegnies Valdez Carlos Fernando
Published: January 2024

El presente artículo centra su análisis en el consentimiento estatal como concepto central y fundamental en el derecho internacional. Aborda su naturaleza jurídica general, su relación con principios del derecho internacional como el pacta sunt servanda, consuetudo est servanda y la buena fe; y su clasificación de acuerdo con la doctrina. Define con rigurosidad el conAsimismo, el autor analiza el consentimiento estatal desde la perspectiva del derecho internacional procesal, particularmente desde la óptica de la Corte Internacional de Justicia. Al respecto, aborda las modalidades de acceso a la jurisdicción de la Corte Internacional de Justicia, así como las prerrogativas que esta tiene para hallarse competente en relación con el consentimiento de las partes.cepto y sus efectos en la esfera internacional.Por último, el artículo propone un análisis del caso del Laudo Arbitral de 1899, entre Guyana y Venezuela, a partir de la relativización del consentimiento estatal a manos de la Corte Internacional de Justicia. Concluye, al respecto, que la Corte generó un equívoco al pretender analizar si el consentimiento manifestado por los Estados había sido inequívoco.
Growing Green: Sustainable Agriculture Meets Precision Farming: A Review
Authors: Kayastha S. , Behera A. , Sahoo J.P. , Mahapatra M.
Published: January 2024

Precision farming involves the use of advanced technologies such as the global positioning system (GPS), sensors and data analytics to make informed decisions on crop management. The integration of sustainable agriculture principles with precision farming techniques offers a holistic approach to address the challenges faced by modern agriculture. This review explores the convergence of sustainable agriculture and precision farming practices, aiming to enhance the efficiency, productivity and environmental sustainability of modern farming systems. The review delves into the principles of precision farming, which involves the use of advanced technologies such as GPS, sensors and data analytics to optimize resource use and improve crop yields. The integration of sustainable practices within precision farming frameworks is a central focus, emphasizing the importance of environmental supervision, soil health and biodiversity conservation. This review also highlights the collaboration between cutting-edge agricultural technologies and environment friendly farming practices, illustrating a path forward for the agriculture industry towards a sustainable and resilient nutritional security.
The impact of YouTube in empowering Algerian young women
Authors: Said Naima
Published: January 2024

Social media studies have shown that the use of social applications affects different aspects of individual lives. This paper explores the impact of social media on the way Algerian young women construct their experiences in the virtual sphere, by following famous young female YouTubers and influencers in their early twenties on YouTube. A thematic analysis of selected videos of the Algerian YouTuber Amira Riaa would shed light on the ways Algerian young women use social media mainly YouTube to be present online and develop themselves by following, interacting, and relating to this famous female model’s real experiences in the virtual world. The analysis has shown that YouTube, consequently, represents a virtual space where these young Algerian women’s interest in consuming social media has transcended to being entertained by watching other women’s lives on this virtual platform, and a space where they can identify and relate to Algerian YouTube content creators’ experiences and opinions and be empowered psychologically.
Keywords: Empowerment; psychological; women; YouTube.
Rural development through people's participation in Gram Sabha: A study from Central India
Authors: Rana Usha , Sagarika Sipra
Published: January 2024

Rural development can never be possible without a robust implementation of governmental policies in rural regions. The Panchayati Raj institutions were introduced in India in 1993 with the goal of rural development through the people's participation. In this context, this study explores the level of involvement of villagers in Gram Sabha and their awareness of state development policies and investigates gender participation in rural development. The study adopts both quantitative and qualitative research methodologies. The data have been collected from the village Chitoura, Sagar, district of Madhya Pradesh (MP) via semi-structured interview methods, case studies, and observations. A total of 50 villagers were selected as respondents through random sampling. Notably, the findings point out that the Panchayati Raj institutions are failing to deliver the development policies on the ground due to a lack of awareness among the villagers and poor participation of women in village activities. This study recorded that caste and gender hinder rural development as some specific castes gained more benefits from the Panchayati Raj institution.
Keywords: Gram sabha; Panchayati Raj institution; rural development; women representatives.
Methods of forming information culture in students
Authors: Anvarov Alisher
Published: January 2024

This article explains information culture and its specific features in the modern era of information culture among students. The scientific article presents an analysis of studies conducted on the culture of using the Internet and social networks among students studying in secondary specialized educational institutions. The information culture of students studying in secondary specialized Islamic educational colleges has been developed and explained extensively. The social factors that determine the lack of a critical approach to the selection of necessary information among students of a special Islamic educational college have been studied. Based on the fact that the acquisition of information culture is a vital necessity for future imams, the author made several proposals and recommendations in this regard. The main factors determining the level of formation of the information culture of students of secondary specialized Islamic education are explained. In the XXI century, every student, every teenager must meet the basic criteria of information culture; the problems of its use in the educational process and, of course, improving the culture of using the Internet are highlighted.
Keywords: Communication; digital technologies; information; internet; social networks.
Mediating Influence of General Process Management Competency on the relationship between Task Inattentiveness and Self-Efficacy for Teamwork among Management Students
Authors: Coetzer Graeme H , Omonuk Joseph , No Sung
Published: January 2024

Purpose: This research study examines the mediating influence of general process management competency (GPMC) on the relationship between task inattentiveness (TIA) and self-efficacy for teamwork (SETW). Design/methodology/approach: One hundred and sixty-four graduate management students completed self-assessment measures of TIA and SETW, and identified a close associate who completed an observer version of a general process management competency measure. Product moment correlations were used to examine the hypothesized relationships between SETW and both TIA and GPMC, and both the Hayes process and the Sobel test were used to test the hypothesis that GPMC mediates the relationship between TIA and SETW. Findings: SETW was significantly correlated with both TIA (r = -0.24, p < 0.01) and GPMC (r = 0.44, p < 0.01). TIA was significantly correlated with GPMC (r = -0.33, p < 0.01). Both the Hayes process and Sobel test (Z = -3.49, p < 0.00) confirmed that GPMC fully mediated the relationship between TA and SETW. Practical implications: Business and management educators need to be aware of the influence of task inattentiveness and general process management competency on self-efficacy for teamwork. Teaching strategies and other developmental resources that address task inattentiveness and promote general process management competency in an integrated manner may help improve self confidence in teamwork, which is a key contributor to team member effectiveness. Originality/value: This is the first study to examine the relationships between TIA, GPMC and SETW. The results of this study highlight the importance of developing teaching strategies and developmental resources that enhance both task attentiveness and general process management competency in an integrated manner to promote greater confidence in ability to work in teams.
Government Information Disclosure and the Expansion of Public Reason
Authors: Fuqi Li , Guanghui Hou
Published: January 2024

In the process of deepening government reform and transforming government functions, the disclosure of government information has increasingly gained widespread attention in both academic and practical circles. Government information disclosure is based on the evolution of rational choice model in organizational decision-making, the introduction of information asymmetry assumption in game theory, and the impact of information asymmetry on the effectiveness of policy decision-making, etc., focusing on the alleviation of information asymmetry. This paper finds that government information disclosure is mainly aimed at expanding public rationality by enriching the amount of information in the government decision-making process, increasing the possibility of monitoring government decision-making behavior, and weakening the influence of subjective factors of decision-makers.
Antígona González: para una poética de lo sagrado en el país de los dolientes
Authors: Yébenes Escardó Zenia
Published: January 2024

Antígona González (2012) de Sara Uribe (Querétaro, 1978) es una obra que no debe ser reducida al lenguaje jurídico y político de la denuncia y los derechos humanos sino que puede ser leída como una poética de lo sagrado. A partir de su vinculación con la Antígona de Sófocles y de la discusión con el homo sacer de Agamben, este artículo contempla Antígona González como una obra que critica el principio de soberanía y subraya la importancia del nombre y del cuerpo, en una poética sagrada de la desapropiación.
Socialization of Bukittinggi City Government Innovations in Disciplining Professional Actors Through Tourism Hero Cards
Authors: Yuniardi Indra , Rasyid Anuar , Ismandianto Ismandianto
Published: January 2024

Based on data from the Bukittinggi Tourism Office, the number of tourists continues to increase. The high number of visits does have a positive impact but the lack of control of professional actors creates problems for visitors. Congestion and cleanliness are one of the impacts of the lack of supervision of the traders. In response to this, the Bukittinggi City Government created an innovation to discipline professional groups through the Tourism Hero Card. The research is descriptive qualitative research. Data were collected through observation, interviews, and documentation. The results of the research show that the Hero Tourism Card is socialized directly and also informed through social media. The innovation has an impact on professional actors because it is quite effective in structuring traders and the location of the trading area. However, Covid-19 caused the innovation diffusion process at the beginning of its release to be less effective. The lack of access to information for some professional actors makes the Hero Tourism Card innovation need special attention in the future.
Conflictividad agraria en la Transición
Authors: Redondo Cardeñoso Jesús Ángel
Published: January 2024

El artículo estudia la conflictividad agraria que tuvo lugar en España en 1979 y 1980 a raíz de los efectos negativos de la segunda crisis del petróleo. En primer lugar, repasa la evolución del movimiento y protestas agrarias durante el tardofranquismo y los primeros años de la Transición. Posteriormente, analiza las causas, génesis y desarrollo de las protestas agrarias entre 1979 y 1980, como fueron las denominadas «jornadas de lucha en el campo» convocadas por COAG (para los días 27 de julio de 1979, 7 de diciembre de 1979 y 4 de febrero de 1980) y otras protestas a escala regional y provincial. El artículo muestra que la conflictividad agraria protagonizada por los agricultores durante la Transición no se agotó con la «guerra de los tractores» de febrero-marzo de 1977, sino que continuó durante los años siguientes y contribuyó decididamente al apogeo de la conflictividad social que vivió España en 1979.
Enfermedad, hambruna y muerte en las prisiones, campos de concentración y unidades de trabajos forzados en Córdoba (1937-1943)
Authors: Navarro López Francisco
Published: January 2024

El franquismo creó una extensa red concentracionaria a lo largo de toda la provincia cordobesa, que paralela a la carcelaria, impuso condiciones infrahumanas a los prisioneros de guerra y presos políticos. Los intentos de aminorar y prevenir el desarrollo de las epidemias por parte de las autoridades sanitarias franquistas se hacían infructuosos ante una inexistente o deficiente asistencia médica en los centros de reclusión. La asiduidad de la pediculosis y la sarna, o la enfermedad del tifus exantemático que se extendían entre los confinados en los campos de concentración y las diferentes unidades de trabajos forzados empeoró las malas condiciones de insalubridad y hacinamiento que tuvieron que soportar los cautivos republicanos. Si durante la guerra las atrocidades se sucedieron continuamente, en la inmediata posguerra la represión sobre los vencidos no cesó. El pánico, terror y la muerte, víctimas de los males más diversos, se propagaba por todas las prisiones dejando a su paso un reguero de fallecimientos que aún hoy en día no se ha podido cuantificar del todo.
Las caras de la Iglesia católica durante la dictadura cívico-militar en Argentina (1976-1983)
Authors: Sánchez-Moreno Manuel
Published: January 2024

La Iglesia católica fue un actor que mantuvo una relación de cooperación y conflicto con la última dictadura cívico-militar en Argentina (1976-1983). Si bien la jerarquía eclesiástica apoyó al régimen en base a una experiencia histórica que había beneficiado el tándem ejército-religión, hubo voces disidentes que fueron reprimidas y apoyaron a los emergentes movimientos de derechos humanos. Se pueden establecer tres posturas de la Iglesia ante la dictadura: la colaboracionista, la disidente y la neutral. Con el objetivo de ver las principales características de esta relación y su evolución, se realizará un análisis de contenidos de documentos tanto del ejército como de la Iglesia católica, legislación, noticias y testimonios recopilados por el autor en Argentina.
China de “todo bajo el cielo” al “Estado civilización”
Authors: Ramírez Ruiz Raúl , Pinto Salvatierra Begoña
Published: January 2024

En el presente artículo se describe el arduo y frustrado proceso de adaptación del modelo de Estado-nación en China. Cuando los conceptos occidentales de nación y Estado llegaron, a finales del siglo XIX, debieron imponerse a una visión del mundo que bajo el principio de “todo bajo el cielo” consideraba a China el único país civilizado del mundo, con autoridad sobre todas las naciones existentes. China, forzada por la situación internacional debió adoptar una idea de Estado-nación restrictiva que desde entonces ha generado una continua tensión entre la mayoría han y las minorías. Las soluciones procedentes del exterior se han demostrado insuficientes y, hoy, China, revitaliza sus formas políticas tradicionales para implementar modelos novedosos como el de “un país, dos sistemas” que tras más de un cuarto de siglo de aplicación está dando paso a la definición de uno nuevo llamado Estado-Civilización.
El fondo fotográfico Hernández-Pacheco
Authors: Lérida Jiménez Alba
Published: January 2024

El presente trabajo partirá de la reflexión teórica acerca de la fotografía como mensaje histórico, para abordar la labor que realizó el naturalista Eduardo Hernández-Pacheco, figura fundamental de la geología, paleontología y geografía española. En la primera mitad del siglo XX se embarcó, junto a su hijo Francisco Hernández-Pacheco, en diversas expediciones científicas que le llevaron hasta alguna de las colonias españolas de África: Sahara, Marruecos o Guinea Ecuatorial. Se pretende analizar su fondo fotográfico personal depositado en la Biblioteca Marqués de Valdecilla, que contiene un total de 400 fotografías de las colonias españolas en África y que retrata detalladamente a las gentes que habitaban aquellos lugares, sus agrestes paisajes y sus diferentes formas de vida.
Antropobiología y etnología en la expedición a la Guinea española (1948)
Authors: Chicharro Manzanares Cristina
Published: January 2024

La institucionalización y el desarrollo de la antropología española tuvo su culmen con la creación del Instituto “Bernardino de Sahagún” de Antropología y Etnología (IBS), afecto al Consejo Superior de Investigaciones Científicas, mas éste no era el único Instituto dedicado al estudio antropológico, puesto que en 1945 se creó el Instituto de Estudios Africanos (IDEA), contando con una sección de antropología y etnología. El discurso colonial y su extrapolación a los estudios antropológicos se tradujo en un aumento de los estudios africanos, aumentándose por ende el número de expediciones antropológicas financiadas por el CSIC y la Dirección General de Marruecos y Colonias. Así pues, en 1948 se produjo la primera expedición bajo la dirección del IDEA y de la Dirección General de Marruecos y Colonias, dirigida por Santiago Alcobé Noguer, uno de los principales antropólogos del primer franquismo.
BARRIERS IN INTERVENTION CHARACTERISTICS OF CLUSTER HOSPITAL (CH) IMPLEMENTATION IN MALAYSIA: AN EXPLORATORY STUDY
Authors:   Institute for Health Management, Ministry of Health Malaysia, Selangor, Malaysia, Khairul Anuar Ili Liyana , Mohd Kamil Nik DewiDelina Nik ,   Institute for Health Management, Ministry of Health Malaysia, Selangor, Malaysia, JihanNoris Nur ,   Institute for Health Management, Ministry of Health Malaysia, Selangor, Malaysia, Bakit Pangie Anak ,   Institute for Health Management, Ministry of Health Malaysia, Selangor, Malaysia, Jie Ng Rui ,   Institute for Health Management, Ministry of Health Malaysia, Selangor, Malaysia, Ibrahim Nor Hayati ,   Institute for Health Management, Ministry of Health Malaysia, Selangor, Malaysia
Published: January 2024

To address an imbalance between congested specialist hospitals and underutilised district non-specialist hospitals, Ministry of Health Malaysia introduced Cluster Hospital (CH) in 2014. Following successful implementations from countries with similar healthcare system such as Hong Kong, and Australia, CH merges hospitals to establish an integrated network of specialist and non-specialist hospitals through shared resources, streamlined services and care coordination. A qualitative study was conducted to explore perceived barriers and boosters towards CH implementation and its sustainability among healthcare providers via semi-structured focus group discussions and in-depth interviews with purposefully selected respondents from the first six CHs. An Interview protocol was developed based on Consolidated Framework for Implementation Research (CFIR) covering five domains; intervention characteristics, outer setting, inner setting, characteristics of individuals, and process. This paper will only highlight the perceived barriers in the intervention characteristics domain. A total of 274 participants from varying professions were interviewed. Interviews were audio-recorded, transcribed and thematic analysis was performed. In this domain, barriers to implementation were found within three constructs; complexity, design quality & packaging, and cost. Issues highlighted include intervention was designed with vague guidelines & policies, distance and travel costs within a CH, medical record safety, huge capital and operating cost involved. It was found that adaptation of evidence-based interventions needs to take into account the local context of an organisation for the implementation to be successful and produce desired outcomes. Thus, these perceived barriers raised by ground-level implementers should be considered and acted upon when strategising towards CH sustainability.
The role of computed tomography in the early detection of damage to the small intestine and mesentery in closed combined trauma (clinical case)
Authors: Popova I. E. , Khamidova L. T. , Titova G. P. , Barmina T. G. , Zabavskaya O. A. , Plyusova N. S. , Sementsova O. V. , Rogal' M. M.
Published: January 2024

Introduction. The number of victims with abdominal trauma over the past 20 years has not tended to decrease due to an increase in the number of road accidents, falls from heights, man-made disasters and natural disasters. Diagnosis of damage to hollow organs should be fast and accurate, since the time factor in providing medical care to such patients is crucial. The delay of surgery for intestinal injury for 24 hours or more is associated with an increase in the mortality rate of up to 30%. In such cases, computed tomography is the method of choice for hemodynamically stable patients with closed abdominal trauma.

The aim is to demonstrate the possibilities of computed tomography in the early detection of damage to the small intestine and mesentery using the example of a clinical case of closed combined abdominal trauma with damage to a hollow organ and multiple injuries of the musculoskeletal system.

Materials and methods. A clinical case of combined trauma of a patient in a traffic accident is described.

Conclusion. In this clinical case, the victim with a combined injury was shown the modern possibilities of computed tomography in early detection of damage to the walls of the small intestine and mesentery, which made it possible to make a timely decision on emergency surgery, avoid serious complications, restore the patient's ability to work and quality of life.
The role of catalicedins in the development of infectious complications in hip replacement
Authors: Dmitrieva L. A. , Morozov A. N. , Say O. V. , Muhomedzyanova S. V.
Published: January 2024

Reducing the risk of infectious complications after hip replacement both in the early and late postoperative period remains an important task. Currently, there is a search for laboratory markers of infection development in the field of surgical intervention with high prognostic significance. Violation of the production of catelecidins LL37 may be a factor contributing to the development of infectious and inflammatory complications. To investigate the concentration of cathelicidin in dynamics in patients with hip replacement and the development of postoperative infectious complications.

Object and methods. A total of 49 people were examined, who were divided into three groups: the first group – 19 patients after hip replacement with no peculiarities during the postoperative period, the 2nd group – 15 patients after hip replacement: with the development of infection in the early stages (n = 6), and 9 patients with late deep complications within 1 year. The third group (n = 15) consisted of clinically healthy individuals. The results of a laboratory study of LL37 catelecidins in peripheral blood and drainage fluid were analyzed.

Results. As a result of the comparative analysis of the results obtained, certain patterns were revealed. Thus, the level of catelecidin in blood serum and drainage fluid in the group of patients with infectious complications was significantly higher than in the group of patients without complications. Blood loss during surgery may be an additional factor contributing to the disruption of the production of antimicrobial peptides. Discriminant analysis revealed that the determination of the level of cathelicidin on the 10th day after surgery and its content in the drainage fluid suggests the development of a postoperative complication in the form of a paraprosthetic infection.
Analysis of the adaptation potential of the cardiovascular system of students studying in medical specialties
Authors: Pavlova O. N. , Gromova D. S. , Makarova-Gorbacheva E. V. , Budaev A. I. , Halitova Yu. A.
Published: January 2024

Relevance. Studying the adaptive potential of students is an important way to assess the level of health and early career guidance of future doctors.

The purpose of the study is to study the adaptive potential of the cardiovascular system among second-year medical university students.

Object and methods. The study involved 507 students of both sexes studying in their second year at Samara State Medical University. At the first stage of the study, anthropometric parameters were studied in all subjects. At the second stage, an analysis of the adaptive potential was carried out by calculating the following indicators: index of functional changes, adaptive potential according to the equation of L.A. Konevskikh, Robinson index.

Conclusions. An analysis of the functional state of the cardiovascular system of medical university students revealed that the majority of students already in their second year have a disruption of adaptation processes, which is associated with low functional capabilities of the body, tension in adaptation mechanisms and disruption in the functioning of regulatory systems.
Treatment of periprosthetic knee joint infection using a spacer with a mixed carbonsilver antibacterial coating in the medium term
Authors: Malyuchenko L. I. , Nikolaev N. S. , Emel'yanov V. Yu.
Published: January 2024

Relevance. Total endoprosthetics is a one of the most common operation for knee pathology. A major complication of joint replacement surgery is periprosthetic infection (PPI). In this work, we looked at the mid-term clinical outcomes of using spacers coated with linear chain carbon doped with silver ions (LC-Ag+) to treat PJI.

Object and methods. The mid-term clinical results of 31 patients with LUP-Ag+ coated spacers were compared to 31 control patients groups utilizing tests of the functional and clinical scales KSS, visual analogue pain scale (VAS), EQVAS, and EQ-5D-5L 2 years following surgery.

Results. According to the clinical questionnaire, the LC-Ag+ group's mid-term outcomes were statistically better than the control group's for clinical KSS 90 vs. 69 points (p = 0.002) and functional KSS – 75.5 vs. 65 points (p = 0.005), VAS – 1.6 vs. 4.2 points (p < 0.001), EQVAS – 95 vs. 72.5 points (p < 0.001), EQ-5D-5L – 0.84 vs. 0.59 points (p = 0.008), respectively.

Conclusions. The combination LC-Ag+ coating increases the mid-term effects of PPI treatment.
The Influence of Aging Anxiety and Perceived Stress on Depression in Middle-Aged Women: The Moderated Mediation Effect of Self-Compassion
Authors:   The Association of Korea Counseling Psychology Education Welfare, TAK Eon-Hyo , LEE A-Ra
Published: January 2024

This study examined the mediating effect of perceived stress in the effect of aging anxiety ondepression in middle-aged women and confirmed whether self-compassion mediates thesemediating effects. To this end, 308 middle-aged women aged 40 to 59 in Korea were measuredfor aging anxiety, depression, perceived stress, and self-compassion. Regression analysis andbootstrapping were used to analyze the data collected in this study through SPSS MacroPROCESS. The research results are as follows: Frist, Perceived stress partially mediated theinfluence aging anxiety and depression. second, The moderating effect of self-compassion wassignificant in the influence perceived stress and depression. Third, self-compassion moderatedthe mediating effect of perceived stress on the relationship between aging anxiety anddepression. Based on these results, we tried to discuss that intervention through self-compassioncan be helpful to reduce depression in middle-aged women in counseling.
The Meta-Analysis on the Effects of Group Counseling for Anger-Control
Authors:   The Association of Korea Counseling Psychology Education Welfare, MOON Eun-Ju
Published: January 2024

This meta-analysis study pointed to evaluate the effectiveness of anger-control groupcounseling of elementary school students. A total of 69 studies published from 2000 to 2023were selected. The results are as in the following: First, a total of 69 studies effect sizes werecomputed and the overall effect size of the programs was 0.586, showing a medium effect size.
Second, regarding the effect size according to mediation variables including program content,utilizing media, participant characteristics, various parameters of group operation. The resultshow programs were most effective when peer relation improvement group counseling wasused with the narrative therapy, group members were 1~2grade, ranging from 9 to 15 persons,for 13 over sessions, 2times a week from 5 to 8 weeks period, not class but non-class. Basedon these results, implications for future research and program practice were discussed.
Design of remote acquisition system for ecological water demand information of an estuarine wetland
Authors:   Vocational and Technical College of Industry, Cao Jiansheng , Bi Xinxi ,   Henan Tianguan Fuel Ethanol Co., Yang Yuanyuan ,   Henan Tianguan Fuel Ethanol Co., Guo Xiaobo ,   Henan Tianguan Fuel Ethanol Co.
Published: January 2024

In order to improve data coverage and data collection efficiency, the design method for a remote collection system of ecological water demand information of an estuarine wetland is proposed. The hardware design of the remote information acquisition system is realized through the overall structure design, the Unified Modeling Language (UML), system outline design, system logic design, and system module division. The information is acquired by polling, and the acquisition frequency is adjusted according to the actual situation and user needs. In the system software design, the Scale-invariant feature transform algorithm (SIFT) is used to extract the image features of the estuarine wetland, and a support vector machine is used to cluster the collected information according to the image features to realize the remote acquisition of water demand information of the estuarine wetland. The experimental results show that the maximum data coverage of the proposed method is 95%, and the data acquisition time is less than 0.2 h, indicating that the proposed method has high information acquisition efficiency and high data coverage.
Reservoir Heterogeneity in the Fluvio-Deltaic Deposits: A Case Study from the Surma Group Succession Exposed in the North-Eastern Surma Basin, Bangladesh
Authors: Rahman Md. Mostafizur
Published: January 2024

Well-exposed fluvio-deltaic Surma Group successions of the northeastern Surma Basin provide a direct analogue to its equivalent subsurface successions—the main hydrocarbon reservoirs in Bangladesh. The various levels of lateral and vertical heterogeneities lead to changes in the subsurface sandbody distributions and their reservoir qualities across fields. The present study aims to identify the heterogeneities in the fluvio-deltaic Surma Group successions by detailed sedimentological analysis of the Mio-Pliocene-aged Surma Group successions. Eleven lithofacies have been identified and based on the recurring pattern of these facies within the Surma Group, five facies associations have been identified. The facies associations indicate that these deposits originated from diverse depositional settings, ranging from the prodelta to the alluvial to delta plain. As a whole, they represent a progressive shallowing upward succession with two transgressive events in the upper and lower parts of the Surma Group. Five levels of heterogeneities such as prodelta mud (HL-I), tidal heterolithic deposits (HL-II & III), interbedded mud units in delta front (HL-IV), and intercalated mud laminae, drapes (HL-V) have been identified in the fluvio-deltaic Surma Group. The study suggests that the various levels of reservoir heterogeneities are controlled by the occurrence and distribution of various facies associations.
A Novel Power Sliding Mode Control Strategy Based on Disturbance Observer for Permanent Magnet Synchronous Motor
Authors: Huang Hao , Yu Chunfeng , Zhang Yuanfeng , Sun Zhonghua , Zhao Zhibin
Published: January 2024

a sensorless control scheme based on novel power converging law sliding mode observer is suggested to realize the sensorless control for the permanent magnet synchronous motor (PMSM). Firstly, by introducing a new power converging law, the problem of slow converging speed/large chattering value dilemma in the conventional converging law is solved; Secondly, in view of the shortcomings of the conventional position and speed estimation algorithm, the high-frequency buffeting in the sliding mode observer will be expanded, a phase-locked loop (PLL) velocity and position estimation strategy is adopted to replace it. Finally, through Matlab/Simulink modeling and motor speed regulation platform experimental results, the sensorless position and speed estimation technology proposed in this paper can respond to the starting speed command of 1000 r/min within 0.05 s, and the starting process has no overshoot. When disturbed by 10Nm loading, the speed fluctuation value can be controlled within 1%.
Szeged Index and Padmakar-Ivan Index of Nilpotent Graph of Integer Modulo Ring with Prime Power Order
Authors: Husni Muhammad Naoval , Wardhana I Gede Adhitya Wisnu , Dewi Putu Kartika , Suparta I Nengah
Published: January 2024

Recently, graphs have started to be used to represent a finite ring. Nikmehr and  Khojasteh in the article  defined the nilpotent graph of a ring . Denoted , is a graph with the set of vertices being all the elements in the ring  Two vertices  and  are adjacent if and only if  is nilpotent elements in the ring . Topological index is a field that discusses graph structure based on the degree of each vertex of a graph and the distance between vertices.  In this study, the author will gives the general formula of the Szeged index and Padmakar-Ivan index of the nilpotent graph graph of the modulo ring with prime power order. The result of this research is a general formula for the topological indices of nilpotent graphs of the integer modulo ring, called the Szeged index and the Padmakar-Ivan index.
The Cox Proportional Hazard Model on Life Insurance Premium Payments Analysis
Authors: Amalliyah Nor
Published: January 2024

Insurance premiums are a sum of money that must be paid by participants of life insurance programs to insurance companies to compensate for losses suffered by participants. The amount of the premium must be in accordance with the sum insured to be received, so that the insurance company has enough money to replace the losses suffered by its customers. In determining the premiums also should not be too large, because it can burden the insurance program customers. Therefore it is necessary to do an analysis to find out the factors (gender, age, amount of coverage, occupation, method of payment of premiums, amount of premium, and type of insurance product) that affect the term of payment ability by the customer. The analysis conducted is using the Cox Proportional Hazard Model. The results obtained in this study are factors that have a significant effect on the period of ability to pay premiums, namely the amount of sum insured, profession and types of insurance product
ROLE OF MSCT AND MRI IN THE DIFFERENTIAL DIAGNOSIS OF MIDFACE COMPLICATIONS IN PATIENTS WITH FUNGAL PATHOLOGIES
Authors:   Tashkent State Dental Institute, ISRAILOVA MAKSUDA N. , YUNUSOVA LALITA R. ,   Tashkent State Dental Institute, KHODJIBEKOVA YULDUZ M. ,   Tashkent State Dental Institute, YULDASHEVA DILSHODA YU. ,   Tashkent State Dental Institute
Published: January 2024

Abstract. Introduction. Fungi are one of the constituents of an ecosystem. There are about 250 known human- pathogenic fungi species: From the widely spread Candida to the pathogene of aspergillosis that may lead to fatal consequences in certain conditions. Studies performed by Russian and foreign authors show the increase in the frequency of chronic sinusitis determined by the presence of fungi or fungal-microbial associations. Aim of this study is to perform the diﬀerential diagnosis of midface complications in patients with fungal pathology according to multispiral computed tomogrsphy and magnetic resonance tomography. Materials and Methods. A retrospective study was conducted based on the ﬁndings of multispiral computed and/or magnetic resonance tomographies of 68 patients. Presence of a fungal process was conﬁrmed by histopathologic, mucroscopic, and cultural investigations. Results and Discussion. Histological investigations of surgical specimen detected the presence of fungal bodies formed by mycelium, i.e., a cluster of densely, compactly located fungal ﬂocci in 28 of 48 (58.3 %): In 28 patients with maxilla sinus lesions, in 14 patients with sohenoidal sinus lesions, and in 5 patients with ethmoidal sinus lesions. In case of acute invasive fungal rhinosinusitis, the computed tomography of paranasal sinuses detected mucosal thickening and the bone density decrease associated with an erosive process. Unilateral lesions, erosions, and thinning of the sinus bone walls. According to magnetic resonance tomography, there was low signal in T2 mode, which is determined by the high concentrations of various metal elements in fungi, as well as by a high protein level and low free water contents in mucine. Conclusions. Visualization is essential to staging the disease and assessing the involvement of deeper structures, which may be clinically unmanifest. Although both computed tomography and magnetic resonance tomography are useful, the contrast-enhanced magnetic resonance tomography is the method of choice and helps assess the spread of the disease, especially regarding the deep extension into maxilla-facial area and brain.
PATHOLOGICAL PROCESSES OF THE ORAL MUCOSA IN CHRONIC RECURRENT APHTHOUS STOMATITIS ON THE BACKGROUND OF GASTRODUODENAL DISEASES
Authors:   Tashkent State Dental Institute, KAMILOV KHAYDAR P. , IBRAGIMOVA MALIKA Kh. ,   Tashkent State Dental Institute, ERGASHEV NURALI A. ,   Institute of Biophysics and Biochemistry, Tashkent
Published: January 2024

Abstract. Introduction. In gastroduodenal diseases, alterations of the oral mucosa (OM) are characterized by various morphological elements, such as erosions, aphthae, ulcers, and pathological processes like acanthosis or atrophy. Chronic inﬂammation that accompanies this process is a protective body reaction histologically manifested by the development of lymphohysteocytic or round cell inﬁltrates. Aim of the study was to investigate morphological changes in OM in chronic recurrent aphthous stomatitis (CRAS) on the background of chronic gastroduodenitis and to conduct a comparative analysis with clinical ﬁndings. Materials and Methods. To conduct a histological study, of a total of 114 patients with CRAS, we selected 40 patients, in which it was accompanied by OM lesions, particularly the formation of aphthae, ulcerative and necrotic elements. All patients underwent a complete history collection and clinical examinations. Results and Discussion. When analyzing chronic gastroduodenitis by gender in patients with CRAS, we found the pathology equally often in both women and men. Of the total of 114 patients with chronic gastroduodenitis, CRAS was diagnosed in 61 women (53.5%) and in 53 men (46.4%). In terms of age, there was CRAS in patients aged 50 years or older (60.5%) more frequently than in younger patients. Conclusions. Analyzing the morphological studies of erosive-ulcerative OM lesions in CRAS patients on the background of chronic gastroduodenitis shows that the most frequent manifestations of the alterations were characterized by the development of the epithelium inﬂammation and ulceration, formation of ulcerative defects, the surface squamous epithelium hyperplasia, and in some cases, the epithelium atrophy and thinning.
OCCURRENCE OF THE ALLELES AND GENOTYPES ON ALLELIC VARIANTS CYP2C9*2 AND CYP2C9*3 IN PAIN SYNDROME PATIENTS TAKING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
Authors:   Samarkand State Medical University, ABDASHIMOV ZAFAR B.
Published: January 2024

Abstract. Introduction. The most clinically signiﬁcant polymorphic markers of the CYP2C9 gene are the amino acid substitutions of CYP2C9*2. One of the human cytochrome P450 types, i.e., cytochrome CYP2C19, is essential to the metabolism of some drugs, including proton pump inhibitors. Genetic polymorphism of СУР2С19 has some pronounced interindividual diﬀerences. Signiﬁcance of genetic polymorphism is detected where the occurrence of variant alleles exceeds 1% in the population. Aim of the study was to improve the principles of pharmacotherapy with nonsteroidal anti-inﬂammatory drugs, as related to the frequency of alleles and genotypes on the allelic variants of CYP2С9*2 and CYP2С9*3 in pain syndrome patients taking nonsteroidal anti-inﬂammatory drugs. Materials and Methods. The study included 69 patients with pain syndrome. Association between being the carrier of genotypes on the CYP2С9*2 and CYP2С9*3 alleles and developing gastropathies as reactions to administering anti-inﬂammatory drugs was investigated by conducting a prospective case-control study. Molecular genetic testing was performed based on the Laboratory of Medical Genetics of the Research Institute of Hematology and Blood Transfusion at the Ministry of Health of the Republic of Uzbekistan. Results and Discussion. No statistically signiﬁcant diﬀerences were found in the frequencies of the CYP2C9 and CYP2C19 alleles between the groups of patients with and without adverse gastrointestinal reactions to administering nonsteroidal anti-inﬂammatory drugs or proton pump inhibitors. Conclusions. Our ﬁndings allow us to suggest that being a carrier of the allelic CYP2C9*2 and CYP2C9*3 variants should be considered as a gastropathy risk factor of using nonsteroidal anti-inﬂammatory drugs. It can be assumed that, to reduce the risk of adverse reactions developed in the patients of this category to nonsteroidal anti-inﬂammatory drugs, the latter ones need a concomitant administration with proton pump inhibitors. It is necessary to continue studying the frequencies of the alleles and genotypes on allelic CYP2С9*2 and CYP2С9*3 variant sin pain syndrome patients taking nonsteroidal anti-inﬂammatory drugs.