bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis of Fanconi Anaemia by Phenotype and Genetic study
Authors: Etaware Peter
Published: November 2022

Fanconi anaemia (FA) is an inherited bone marrow failure syndrome (IBMFS) that is common among children, in a ratio of one (1) person out of a population of 181 individuals. Early screening and/or detection of FA among intending couples or families with history of IBMFS is very important, to avoid bearing children with physical deformities and high risk of cancer development, as most sufferers have a very high possibility of the development of cancer. Therefore, this research was aimed at creating awareness on the dangers of late detection of IBMFS related diseases, basically Fanconi Anaemia.The most significant marker for Fanconi Anaemia (FA) diagnosis is the appearance of recurrent patterns of chromosome breakages. Fractures were noticeable when chromosome samples were treated with Diepoxybutane (DEB), Mitomicin C (MMC) or other similar chemical treatments. PCR and Bone Marrow Biopsy were deployed as confirmatory test.
Estimación de las propiedades psicométricas del instrumento de medición de adicción al sexo (MAS)
Authors:   Fundación Universitaria Konrad Lorenz, Bogotá, Colombia, Montaño Estupiñán Diana Carolina , Pardo Jaime Leonardo ,   Universidad Central, Bogotá, Colombia, Marchal-Bertrand Laurent ,   Fundación Universitaria Konrad Lorenz, Bogotá, Colombia
Published: November 2022

Introducción: El instrumento MAS, una prueba para evaluar adicción al sexo, ha presentado inconvenientes en el nivel factorial. Por esto, esta investigación buscó estimar las propiedades psicométricas de dicho instrumento, en población colombiana. Método: Inicialmente, se realizó un juicio de expertos para establecer la validez de contenido, a través de la V de Aiken; luego se aplicó el MAS y la escala de inhibición/excitación sexual (SIS/SES) a 337 participantes, por medio de un formulario web (Google forms), de los cuales 312 cumplieron con los criterios de inclusión (221 mujeres y 91 hombres) con edades en el rango 18-65 años (x_= 28.49, DE = 9.77). Mediante SPSS, se calculó el alfa de Cronbach, la correlación de Pearson y se hizo un análisis factorial con rotación Varimax. Resultados: Los análisis reflejaron una buena confiabilidad, una correlación ajustada a lo esperado, en relación con la prueba SIS/SES y el análisis factorial arrojó seis factores que presentan diferencias en comparación con la prueba planteada inicialmente. Conclusión: La prueba MAS presenta un adecuado nivel de confiabilidad, pero no cuenta con una validez de constructo adecuada.
Ivana Brlić-Mažuranić i jej Brlićevac
Authors: Gostomska Anita
Published: November 2022

The article, based on the commemorative books of the Brlićevac summer house and the correspondence of the Croatian writer Ivana Brlić-Mažuranić, attempts to show the influence that the family estate had on Brlić-Mažuranić and her work. Atthe estate in the immediate vicinityof Brod, where the spouses lived, the family spent the summer months for many consecutive years and Ivana Brlić-Mažuranić wrote most of her works. The close contact with nature, which this place provided to a nature-loving writer, became the dominant source of her inspiration, it also guaranteed great well-being, unattainable in other places she lived ( Brod,Zagreb ). The property played a huge role in the life of the famous Croatian who, in her time free from the work in the vineyard, willingly devoted herself to recreation typical of a summer resort, and each celebration of the moments spent together with the loved ones, led to a kind of sacralization of this space.
Криптохристиянски — постапофатичен — постсекуларен
Authors: Джевиецка Евелина
Published: November 2022

This article is a review of the study entitled Защото е на скрито… Християнският светоглед в творчеството на Атанас Далчев (Because It Is Hidden… The Christian Worldview in the Works of Atanas Dalchev ), byKamen Rikev ( Lublin: Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej, 2020, pp. 340 ).
Rozwój i modernizacja terenów zdegradowanych na przykładzie Kamionki Piast w Opolu
Authors: Rajchel Dariusz , Rajchel Anna
Published: November 2022

W strukturze przestrzennej miast oprócz terenów mieszkaniowych, usługowych, przemysłowych czy rekreacyjno-wypoczynkowych występują tereny poprzemysłowe, które wymagają określonych prac umożliwiających zmianę ich przeznaczenia. Na obszarach poprzemysłowych najczęściej wprowadza się funkcję usługową, np. handlową, czy mieszkaniową, np. lofty, ale występują również rejony, które mogą być przekształcone w teren zieleni z funkcją rekreacyjno-wypoczynkowo-sportową. Takim terenem jest Kamionka Piast w Opolu. Jest to obszar po byłej cementowni zlokalizowany w centralnej części miasta w pobliżu osiedli mieszkaniowych, terenów sportowych z infrastrukturą oświatową, zakładami naprawy taboru kolejowego. Celem artykułu było zaprezentowanie działań podjętych przez miasto Opole związanych z rewitalizacją, rekultywacją oraz remediacją zdegradowanego terenu poprzemysłowego i przekształceniem go w jedno z atrakcyjniejszych miejsc Opola pod kątem wypoczynkowym, rekreacyjnym i przyrodniczym. Ponieważ prace związane z ożywieniem kamionki były wykonywane w ramach projektu, w artykule odwołano się do dokumentacji projektowej, aktów prawnych, lokalnych dokumentów strategicznych dotyczących rewitalizacji miejsc zdegradowanych, polskich i zagranicznych opracowań na ten temat. Kamionka Piast po rewitalizacji jest jednym z atrakcyjniejszych miejsc Opola pełniącym funkcję rekreacyjną, wypoczynkową, sportową, edukacyjną. Powstanie nowych osiedli, zwłaszcza mikroapartamentów, cieszy się dużą popularnością wśród studentów. Zachowanie cennych gatunków roślin i zwierząt oraz zabezpieczenie terenu przed degradacją wpłynęło na poprawę przestrzeni i krajobrazu.
Obszary depopulacyjne w makroregionie centralnym i ich analiza pod kątem zaawansowania starości demograficznej w drugiej dekadzie XXI w.
Authors: Majdzińska Anna
Published: November 2022

W opracowaniu postawione zostały dwa cele badawcze: analiza natężenia procesów depopulacyjnych w makroregionie centralnym w drugiej dekadzie XXI w. (w szczególności: identyfikacja gmin charakteryzujących się corocznym ubytkiem populacji oraz wskazanie czynników (typów) depopulacji na tych obszarach), a także analiza zaawansowania tych jednostek administracyjnych pod względem procesu demograficzne- go starzenia się.

W badaniu wykorzystano wskaźniki natężenia i struktury. Dokonano też klasyfikacji gmin według typów przyrostu i ubytku populacji, której podstawę stanowiła koncepcja własna nawiązująca do metody Webba (1963). W opracowaniu użyto danych GUS dla województw i gmin makroregionu centralnego w latach 2011–2020.
SRPX2 attenuated oxygen–glucose deprivation and reperfusion-induced injury in cardiomyocytes via alleviating endoplasmic reticulum stress-induced apoptosis through targeting PI3K/Akt/mTOR axis
Authors: Sun Zhiyuan , Gao Xin
Published: November 2022

Myocardial infraction (MI) is the leading cause of high morbidity and mortality worldwide. It was still urgently needed to find new and effective drugs for MI treatment by the use of myocardial ischemia/reperfusion (I/R) model. Sushi repeats contain the protein X-Linked 2 (SRPX2), which regulates a variety of important cell functions. However, its possible role in myocardial I/R and the progression of MI is still unclear. In this study, we investigated the role of SRPX2 in myocardial I/R. SRPX2 showed low expression in IR rats and H9C2 cells induced by oxygen–glucose deprivation/reperfusion (OGD/R). SRPX2 could increase OGD/R-induced H9C2 cell survival. In addition, SRPX2 suppressed the apoptosis of OGD/R-induced H9C2 cells. Furthermore, we found that SRPX2 could inhibit ER stress induced by OGD/R in H9C2 cells. Mechanically, we found that SRPX2 suppressed the PI3K/Akt/mTOR pathway, thus attenuating OGD/R -induced injury in H9C2 cells. Therefore, SRPX2 has the potential to serve as a target for MI treatment.
Stable carbon and nitrogen isotope analyses of human and animal skeletal remains unearthed at Zengpiyan and Dayan sites in Guilin
Authors: Liu Xiaodi , Wang Ran , Hu Yaowu
Published: November 2022

Stable carbon and nitrogen isotope analyses, together with AMS radiocarbon dating of human and animal bones unearthed from the Zengpiyan and Dayan sites in Guilin of Guangxi suggest a relatively stable environment dominated by C3 plants, which was supplemented by a small amount of C4 plants. Although inhabitants of the two Neolithic sites relied mainly on freshwater resources, they differed significantly in their dietary structure from the Early to Middle phases. The Early Neolithic inhabitants (n=6) consumed similar foods in their diet. By contrast, the Middle Neolithic people (n=11) procured and consumed more terrestrial foods from diverse sources. The transition to a broad dietary spectrum was likely interlinked to the shifts in population structures, environmental adaptation, and foraging ranges.
Lexical variations in Asian Chinese speaking communities: a corpus-informed study of online, offline, and digital
Authors: Yip Jesse Wai Chi , Tang Sze-Wing
Published: November 2022

Studies on Chinese lexical variations, an emerging field in research of Global Chinese, remain scarce. Drawing upon the notion of onomasiological variation, this study employs corpus linguistics to examine semantic and grammatical characteristics of Chinese variations of three timely lexicons, including online, offline, and digital in the Greater China Region like the mainland of China, Taiwan, and Hong Kong, and overseas countries including Singapore and Malaysia. The results revealed Chinese variation patterns across regions and indicate two tendencies. First, the variations of a lexicon are identical to one another when the selected Chinese speaking communities tend to use different Chinese variations. Second, the variations are likely to be semantically variant when the communities have the same tendency in using the variations. This study argues that corpus linguistics is applicable and appropriate in the research of Chinese lexical variations, as it allows both quantitative and qualitative analysis.
Mother tongue to heritage language metamorphosis: the case of Mandarin Chinese in Canada
Authors: Makarova Veronika , Xiang Qin
Published: November 2022

This article compares Mandarin Chinese (MC) proficiencies of bi/multilingual children from immigrant families in Canada (BM) with those of monolingual (bidialectal) children (M) from China across two age groups (5–7 and 10–12). The purpose of the comparison is to identify the threshold of mother tongue to heritage language shift among Canadian bi/multilinguals. The results of bivariate ANOVA analysis of 28 speech parameters in children’s narratives elicited with the help of picture prompts demonstrate significant effects of language and age groups on proficiency parameters as well as interactions between language and age group factors. In the younger age group (5–7), bi/multilinguals proficiency is higher in six parameters, and lower in eight parameters, as compared to monolinguals, i.e., language proficiencies of bi/multilinguals are overall on par with those by monolinguals. By contrast, in the older participant group (10–12), there is a higher number of significant differences between BM and M participants (20 out of 28 parameters), and monolinguals have higher proficiencies in all these parameters. Furthermore, within the language group, cross-age comparisons display a significant improvement in 16 speech parameters for the older monolinguals group as compared to the younger group, but none at all for the bi/multilinguals older versus younger groups. The results suggest that for children from immigrant families in the given location and settings, the threshold of Mandarin Chinese shift from a mother tongue to a heritage language occurs between the ages of 8–9 and is largely completed by the age of 10–12, as evidenced by lack of further development of speech parameters in the 10–12 BM group. These results are explained by the impact of majority language education and other social factors.
香港社区词的词义研究
Authors: 孙 银新
Published: November 2022

文章就香港社区词的词义进行探讨，主要研究以下四个问题：香港社区词词义的特点，香港社区词词义的形成方式，香港社区词中多义词的不同意义之间的联系方式，香港社区词词义关联方式与普通话词义关联方式上的异同。文章认为，概括起来，香港社区词里，无论是单义词还是多义词，在词汇意义的侧重点、词的色彩意义、词义的委婉含蓄程度、词义的构成理据等方面都呈现了鲜明的特点。香港社区词词义的形成方式主要有五种：依靠单个词素的借代意义构成社区词的词义，依靠单个词素的比喻意义构成社区词的词义，依靠单个词素的特有意义构成社区词的词义，依靠整个词中各个词素意义通过比喻构成社区词的词义，依靠整个词中各个词素意义通过借代构成社区词的词义。香港社区多义词词义的关联方式主要有以下七种：比喻、借代、特指、泛指、引申、类比、比拟等。香港社区词中的多义词跟共同语普通话里多义词在词义的关联方式上有同有异，二者都具有比喻、借代、特指、引申四类; 而泛指、类比、比拟是社区词词义特有的类型。
马来西亚华语程度副词的语体分布研究
Authors: 张 欣怡 , 王 晓梅
Published: November 2022

提要：

相关文献显示，语体对程度副词的语法表现具有一定影响，而现有的马来西亚华语程度副词研究多基于单一语体语料，缺乏在书面语和口语中的语体分布考察。鉴于以上研究现状，本文采用语料库研究法，分别创建马来西亚华语书面语料库（476万字）和口语语料库（47.3万字），分析了71个程度副词的语体分布情况。同时采用比较研究法，将马来西亚华语与普通话进行比较，指出马来西亚华语程度副词语体分布的特殊性。研究结果发现，马来西亚华语程度副词根据其语体分布可分为五类：书面语性、书面语常用、通用、口语常用和口语性程度副词。此外，马来西亚华语与普通话语体分类一致的程度副词约占半数，而分类不一致的部分则体现出马来西亚华语“白的更白，文的更文”以及“文白混合”的特点。本研究对马来西亚华语程度副词的语体分布进行了系统性的梳理，挖掘其特殊性，希望能加深对马来西亚华语词类特点的认识。
Novel zero waste tactics for commercial vegetables – recent advances
Authors: Srenuja Dekka , Shanmugam Akalya , Nair Sinija Vadakkepulppara Ramachandran
Published: November 2022

Commercial vegetables include tomatoes, potatoes, onions, and eggplant due to their surplus production, availability, and affordability. The valorisation of the massive wastage of commercial vegetables and providing a long-term solution has been challenging. The review addresses the implications of biowastes on the environment and fosters the recent investigations into valorising commercial vegetable waste to develop multiple value-added products. It discussed the outcomes of the multiple technologies, majorly on green chemistry extraction, while outlining other methods such as fermentation, enzymatic treatments, 3D printing foods, high-pressure homogenisation, microencapsulation, bio-absorption method, and pyrolysis for their respective vegetable wastes. Agri-residues can be a valuable source for formulating functional ingredients, natural additives, biodiesel, dyes, and animal feed. This comprehensive review proposes a strategy to upcycle low-cost biowaste to boost the economic and ecological benefits. The current review captures the interests and great collaborations between researchers, industrialists, policymakers, waste management bodies, and eco-activists.
On arithmetic properties of solvable Baumslag–Solitar groups
Authors: Hayez Laurent , Kaiser Tom , Valette Alain
Published: November 2022

For

0
<
α
≤
1

0<\alpha\leq 1

, we say that a sequence

(

X
k

)

k
>
0

(X_{k})_{k>0}

of 𝑑-regular connected graphs has property

D
α

D_{\alpha}

if there exists a constant

C
>
0

C>0

such that

diam
⁡

(

X
k

)

≥

C
⋅

|

X
k

|

α

\operatorname{diam}(X_{k})\geq C\cdot\lvert X_{k}\rvert^{\alpha}

.
We investigate property

D
α

D_{\alpha}

for arithmetic box spaces of the solvable Baumslag–Solitar groups

BS
⁡

(
1
,
m
)

\operatorname{BS}(1,m)

(with

m
≥
2

m\geq 2

): these are box spaces obtained by embedding

BS
⁡

(
1
,
m
)

\operatorname{BS}(1,m)

into the upper triangular matrices in

GL
2

⁢

(

Z
⁢

[

1
/
m

]

)

\mathrm{GL}_{2}(\mathbb{Z}[1/m])

and intersecting with a family

M

N
k

M_{N_{k}}

of congruence subgroups of

GL
2

⁢

(

Z
⁢

[

1
/
m

]

)

\mathrm{GL}_{2}(\mathbb{Z}[1/m])

, where the levels

N
k

N_{k}

are coprime with 𝑚 and

N
k

∣

N

k
+
1

N_{k}\mid N_{k+1}

.
We prove that

if an arithmetic box space has

D
α

D_{\alpha}

, then

α
≤

1
2

\alpha\leq\frac{1}{2}

;

if the family

(

N
k

)

k

(N_{k})_{k}

of levels is supported on finitely many primes, the corresponding arithmetic box space has

D

1
/
2

D_{\smash{1/2}}

;

if the family

(

N
k

)

k

(N_{k})_{k}

of levels is supported on a family of primes with positive analytic primitive density, then the corresponding arithmetic box space does not have

D
α

D_{\alpha}

for every

α
>
0

\alpha>0

.

Moreover, we prove that if we embed

BS
⁡

(
1
,
m
)

\operatorname{BS}(1,m)

in the group of invertible upper-triangular matrices

T
n

⁢

(

Z
⁢

[

1
/
m

]

)

T_{n}(\mathbb{Z}[1/m])

, then every finite index subgroup of the embedding contains a congruence subgroup.
This is a version of the congruence subgroup property (CSP).
HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells
Authors: Wang Yuyan , Wang Jinfeng , Zhao Anqi , Huang Xin , Zhang Xin
Published: November 2022

Cervical cancer is the fourth most common cancer and the fourth leading cause of cancer death in women. Human papillomavirus (HPV16) E6/E7 heterogenous expression in C33A cells increased the mRNA and protein levels of KIF2A, while siRNA deletion of endogenous E6/E7 reduced the mRNA and protein levels of KIF2A in SiHa cells. KIF2A promoted cell migration and invasion, and regulated the expression of epithelial–mesenchymal transition-related proteins in C33A and SiHa cells. The exogenous expression of E6/E7 in C33A cells increased the phosphorylation of Akt, ERK, and JNK. However, Akt (API-2) and ERK (PD98059) inhibitors had no effect on the increase in KIF2A expression induced by E6/E7, while JNK inhibitors (JNK-IN-8 and SP600125) blocked the increase in KIF2A expression induced by E6/E7. The exogenous expression of E6/E7 increased the levels of transcription factor c-Jun, which is the classic substrate of JNK. Knockdown of c-Jun reduced the increase in KIF2A expression induced by E6/E7. In summary, KIF2A plays a key role in the motility and metastasis of cervical cancer. HPV16 E6/E7 can increase the levels of transcription factor c-Jun by activating the JNK signal, thereby up-regulating the transcriptional expression of KIF2A.
The Ras GTPase‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL‐1β release via exosomes
Authors: Liao Yun , Chen Xing , Miller‐Little William , Wang Han , Willard Belinda , Bulek Katarzyna , Zhao Junjie , Li Xiaoxia
Published: November 2022

IL‐1β can exit the cytosol as an exosomal cargo following inflammasome activation in intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)‐dependent manner. The mechanistic connection linking inflammasome activation and the biogenesis of exosomes has so far remained largely elusive. Here, we report the Ras GTPase‐activating‐like protein IQGAP1 functions as an adaptor, bridging GSDMD to the endosomal sorting complexes required for transport (ESCRT) machinery to promote the biogenesis of pro‐IL‐1β‐containing exosomes in response to NLPR3 inflammasome activation. We identified IQGAP1 as a GSDMD‐interacting protein through a non‐biased proteomic analysis. Functional investigation indicated the IQGAP1‐GSDMD interaction is required for LPS and ATP‐induced exosome release. Further analysis revealed that IQGAP1 serves as an adaptor which bridges GSDMD and associated IL‐1β complex to Tsg101, a component of the ESCRT complex, and enables the packaging of GSDMD and IL‐1β into exosomes. Importantly, this process is dependent on an LPS‐induced increase in GTP‐bound CDC42, a small GTPase known to activate IQGAP1. Taken together, this study reveals IQGAP1 as a link between inflammasome activation and GSDMD‐dependent, ESCRT‐mediated exosomal release of IL‐1β.
The plant FYVE domain‐containing protein FREE1 associates with microprocessor components to repress miRNA biogenesis
Authors: Li Hongbo , Li Tingting , Li Yingzhu , Bai Haiyan , Dai Yanghuan , Liao Yanglan , Wei Juan , Shen Wenjin , Zheng Binglian , Zhang Zhonghui , Gao Caiji
Published: November 2022

FYVE domain protein required for endosomal sorting 1 (FREE1), originally identified as a plant‐specific component of the endosomal sorting complex required for transport (ESCRT) machinery, plays diverse roles either in endosomal sorting in the cytoplasm or in transcriptional regulation of abscisic acid signaling in the nucleus. However, to date, a role for FREE1 or other ESCRT components in the regulation of plant miRNA biology has not been discovered. Here, we demonstrate a nuclear function of FREE1 as a cofactor in miRNA biogenesis in plants. FREE1 directly interacts with the plant core microprocessor component CPL1 in nuclear bodies and disturbs the association between HYL1, SE and CPL1. Inactivation of FREE1 in the nucleus increases the binding affinity between HYL1, SE, and CPL1 and causes a transition of HYL1 from the inactive hyperphosphorylated version to the active hypophosphorylated form, thereby promoting miRNA biogenesis. Our results suggest that FREE1 has evolved as a negative regulator of miRNA biogenesis and provides evidence for a link between FYVE domain‐containing proteins and miRNA biogenesis in plants.
Multivariable analysis to determine risk factors associated with abortion in mares
Authors: Roach J M , Arango-Sabogal J C , Smith K C , Foote A K , Verheyen K L , de Mestre A M
Published: November 2022

Risk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between days 70 and 300 post-cover). Given the causes of abortion differ from those of EPL, likely too will the risk factors. A retrospective cohort study was carried out to identify risk factors associated with abortion in UK- and Irish-based Thoroughbreds, collecting data on 20 exposure variables over a 5-year period. A generalized linear mixed model was utilized to evaluate the associations between exposure variables and abortion, with clustering of observations accounted for at the mare and farm level. Variables with a likelihood ratio test (LRT) P value < 0.2 were entered into the model in a forward stepwise approach. Pregnancy outcome was available on 4439 pregnancies from 2510 mares. Having had two or more prior abortions (odds ratio (OR): 7.91, 95% CI: 2.86, 21.88), conceiving on the second or subsequent covered estrous cycle (OR: 1.84, 95% CI: 1.22, 2.78) and conceiving multiple conceptuses (OR: 1.68, 95% CI: 1.02, 2.76) were associated with an increased risk of abortion compared to null parous, first estrous cycle covers and singleton conceptions, respectively. Increasing paternal age (OR: 0.95, 95% CI: 0.90, 0.99) was associated with a decreasing risk of abortion. Mare and farm variance were not significant in the final model, LRT P = 0.43. These findings provide evidence-based data to inform Thoroughbred breeding management practices to help mitigate abortion risk.

Lay summary

This is the first study to identify the risk factors (characteristics which change the chance of an event) for abortion (miscarriage between days 70 and 300 of pregnancy) in the horse. Statistical models were used to account for the interactions between 20 different factors. The factor which increased the mare’s risk of having an abortion the most was when she had had two or more abortions prior to the pregnancy. Additionally, when the mare was initially pregnant with twins but one of those pregnancies was reduced, the remaining pregnancy was at an increased risk of aborting. Older mares were not at an increased risk of abortion like in humans; however, pregnancies fathered by older stallions were less likely to abort than those from younger stallions. The findings of this study can inform horse breeding practices to help reduce the chance of an abortion.
Interaction between the components in Tm-Cr-Ge system at 1070 K
Authors: Romaka L. , Stadnyk Yu. , Romaka V.V. , Konyk M.
Published: November 2022

The phase equilibrium diagram of the Tm–Cr–Ge ternary system was constructed at a temperature 1070 K based on the results of X-ray phase, microstructural analyzes and energy-dispersive X-ray spectroscopy in the whole concentration range. At the temperature of investigation, two new ternary compounds are realized in the system: TmCr6Ge6 (SmMn6Sn6 structure type, space group P6/mmm, a=0.51506(1), c=0.82645(2) nm) and Tm4Cr4Ge7 (Zr4Co4Ge7 structure type, space group I4/mmm, а=1.39005(9), с=0.54441(1) nm). Inclusion of Cr atoms in the structure of the binary germanide TmGe2 (structure type ZrSi2) up to 10 at. % Cr leads to the formation of a solid solution TmCrxGe2 (x = 0-0.33).
Improving the methodology of developing information and communication competence of future professional education teachers
Authors: KHIMMATALIEV DUSTNAZAR , TURAEV MUZAFFAR
Published: November 2022

This monograph provides information on improving the didactic support for the development of information and communication competence of students in the field of “Vocational education in the field of information and communication technologies” in technical higher education institutions, modeling the process of developing information and communication competence of future teachers, preparation of future teachers for individual projects. issues of improving the methodology of developing communicative competence and determining the level of development of their information and communicative competence, the development of methodological recommendations. The monograph is intended for heads of vocational education institutions, vocational education teachers and researchers conducting research in the field of vocational education.
The social quality policy: theory and international approaches in the context of the Ukraine’s post-war reconstruction task
Authors:   SO “Institute for Economics and Forecasting, National Academy of Sciences of Ukraine” 26, Panasa Myrnoho Str., Kyiv, 01011, Ukraine, Burlay T. V. , Dmytruk D. A. ,   SO “Institute for Economics and Forecasting, National Academy of Sciences of Ukraine” 26, Panasa Myrnoho Str., Kyiv, 01011, Ukraine, Kostrytsia V. І. ,   Association of Employers' Organizations of Ukraine 34, Khreshchatyk Str., Kyiv, 01001, Ukraine, Levin R. Ya. ,   SO “Institute for Economics and Forecasting, National Academy of Sciences of Ukraine” 26, Panasa Myrnoho Str., Kyiv, 01011, Ukraine
Published: November 2022

The paper presents the expediency of the formation and implementation of post-war Ukraine state policy under the basics of the social quality scientific concept, used to improve the social parameters of the European Union development. The authors discuss the general theoretical basis of the social quality concept, the essential milestones of its development, key foundations and concepts, and the approaches proposed by the UN Economic and Social Council, the UN Economic Commission for Europe, the International Labour Organization, the International Association on Social Quality to ensure modern societies’ social quality of life, its quantitative and qualitative assessment. Attention is focused on the expediency of the post-war introduction of the social quality approach into the system of state administration of Ukraine, which can help politicians and citizens to rethink the strategy of Ukrainian society development in the European direction based on socio-economic security, social cohesion, social inclusion, guaranteed social opportunities, and to root social values of equality, solidarity, social justice, and human dignity. The authors determined the relevance of the need to adapt the international approaches of social quality to the implementation in the functioning and development of Ukraine’s public administration system in the reconstruction of post-war Ukraine, focusing primarily on overcoming the consequences of the war. The paper shows the critical importance of the efforts that Ukraine has made since the beginning of the war to support the institutional and financial sustainability of the national social protection system and the implementation of state policy measures to promote employment and prevent the destruction of the national labour market. It is argued that the introduction into the system of public administration of post-war Ukraine of the concept of social quality adapted to domestic conditions should contribute to the “social contract” to gradually find a reasonable balance between two priorities: simultaneous increase of efforts to systematically eliminate threats of external aggression and accelerated restoration of the national socio-economic space on the principles of sustainable, inclusive development.
Digest of U-Report surveys: 3rd quarter of 2022 (return of Ukrainians from abroad, human trafficking, waste management)
Authors:   NGO “YouthUp” 29/6, Shota Rustaveli Str., Kyiv, 01033, Ukraine, Demchuk V. S.
Published: November 2022

The results of surveys of the innovative youth project U-Report for July – September 2022: return of Ukrainians from abroad, human trafficking, waste management.
The Saudi Arabian Women Military Existence in the Islamic Perspective
Authors: Muis Afni Regita Cahyani , Matin Usep Abdul
Published: November 2022

Purpose                  The purpose of this research was to explain in depth about the role of women army into Saudi Arabia’s military institutions in Mohammad Bin Salman regime. Method                   The study was a qualitative research with descriptive design using a primary data that were the journalists’ and academicians’ opinion or ideas. It used interviews with a researcher for the Center for Islamic and Occidental Studies, University of Darussalam Gontor, and with the journalist and academician from King Saud University. The study also depended on the secondary data literatures review like book, journal, and official website. The data then were analyzed qualitatively using the Islamic perspective of the women role in life.  Results/FindingsAs a state which originally tightened the rules for women in the public sphere, the existence of women military in Saudi Arabia was a certain reformist. The engagement of woman military into the state affairs has contributed to Arab Saudi’s security stability that becomes the heart of Middle East as the most frequently visited by foreign people. It has a positive approach for improving the security system of Saudi Arabia as a global image builder. ConclusionThe urgency of women military in Saudi Arabia is to answer the public needs and service. Women Military in Saudi Arabia become a non-combatant for manifestation of the Kingdom of Saudi Arabia's vision to provide an opportunity for women into the public sphere. The Saudi Arabia's women military still maintains sharia principles as a political instrument.
Statistical Modeling using A New Hybrid Form of The Inverted Exponential Distribution with Different Estimation Methods
Authors: Adubisi O. D. , Adubisi C. E.
Published: November 2022

This paper introduces a new four-parameter distribution called the exponentiated Gompertz generated inverted exponential (EGGIE) distribution. Explicit expressions of the structural properties such as the ordinary and incomplete moments, probability weighted moments, quantile function, Lorenz and Bonferroni curves, entropies, and order statistics are derived. The empirical findings indicate that the maximum likelihood procedure dominates the other estimators in the simulation study while the Cramer-Von Mises procedure dominates in the two real datasets applications. We demonstrate the superiority of the EGGIE distribution over the Gompertz Lomax, odd Fréchet Inverse exponential, generalized inverse exponential, generalized inverse exponential, exponential inverse exponential, and Gompertz Weibull distribution using the maximum likelihood procedure utilizing two real datasets applications. The findings show that the EGGIE distribution yields the best goodness of fit to the two datasets.Keywords: exponentiated Gompertz generated family; inverse exponential distribution; Kolmogorov-Smirnov statistic; Anderson-Darling; maximum product spacing. AbstrakPaper ini memperkenalkan distribusi 4-parameter baru yang disebut dengan distribusi exponentiated Gompertz generated inverted exponential (EGGIE). Ekspresi eksplisit sifat struktural dari distribusi ini diturunkan, seperti momen biasa dan momen tak lengkap, momen probabilitas terboboti, fungsi kuartil, kurva Lorenz dan Bonferroni, entropi, dan statistik urutan. Temuan empiris menunjukan bahwa prosedur maksimum likelihood mendominasi estimator lainnya pada studi simulasi, sementara prosedur Cramer-Von Mises mendominasi pada aplikasi dua dataset nyata. Peneliti menunjukkan keunggulan dari distribusi EGGIE dibandingkan distribusi Gompertz Lomax, odd Frechet Inverse exponential, generalized inverse exponential, exponential inverse exponential, dan Gompertz Weibull menggunakan metode maksimum likelihood yang diaplikasikan pada dua dataset nyata. Hasil menunjukan bahwa distribusi EGGIE menghasilkan kecocokan model yang baik pada kedua dataset.Kata Kunci: keluarga bangkitan exponentiated Gompertz; distribusi inverse exponential; Kolmogorov-Smirnov statistic; Anderson-Darling; maximum product spacing. 2020MSC: 62E10
Implementation of machine learning models to determine the appropriate model for protein function prediction
Authors: Golenko Yekaterina ,  Ismailova Aisulu , Shaushenova Anargul , Mutalova Zhazira , Dossalyanov Damir , Ainagulova Aliya , Naizagarayeva Akgul
Published: November 2022

Predicting the function of proteins is a crucial part of genome annotation, which can help in solving a wide range of biological problems. Many methods are available to predict the functions of proteins. However, except for sequence, most features are difficult to obtain or are not available for many proteins, which limits their scope. In addition, the performance of sequence-based feature prediction methods is often lower than that of methods that involve multiple features, and protein feature prediction can be time-consuming. Recent advances in this field are associated with the development of machine learning, which shows great progress in solving the problem of predicting protein functions. Today, however, most protein sequences have the status of «uncharacterized» or «putative».
The need to assess the accuracy of identification of protein functions is an urgent task for machine learning approaches used to predict protein functions. In this study, the performance of two popular function prediction algorithms (ProtCNN and BiLSTM) was assessed from two perspectives and the procedures for building these models were described.
As a result of the study of Pfam families, ProtCNN achieves an accuracy rate of 0.988 % and bidirectional LSTM has an accuracy rate of 0.9506 %. The use of the Pfam dataset allowed increasing the classification accuracy due to the large training dataset. The quality of the prediction increases with a large amount of training data.
The study demonstrated that machine learning algorithms can be used as an effective tool for building protein function prediction models, in particular, the CNN network can be adapted as an accurate tool for annotating protein functions in the presence of large datasets.
Determining the structure and properties of heat-resistant titanium alloys VT3-1 and VT9 obtained by electron-beam melting
Authors: Akhonin Serhii , Pikulin Oleksandr , Berezos Volodymyr , Severyn Andrii , Erokhin Oleksiy , Kryzhanovskyi Vitalii
Published: November 2022

This paper reports a comprehensive study that investigated the quality of heat-resistant titanium alloys VT3-1 and VT9 obtained by the method of electron beam melting (EBM). It is shown that EBM makes it possible to produce high-quality metal of ingots of heat-resistant titanium alloys VT9 and VT3-1.
Semi-finished articles were made in the form of bars from ingots obtained by the EBM method. It was established that in the macrostructure of the deformed metal there are no cracks, delamination, cavities, metal and non-metallic inclusions. The macrostructure of the metal of the bars corresponds to 4 points for the alloy VT3-1 and 4–5 points for the alloy VT9 on the 10-point scale of microstructures of instruction 1054-76. It was shown that the metal microstructure of forged bars of VT9 alloy consists of primary β grains with a continuous or intermittent α-rim along the grain boundaries 3–4 μs thick. The structure of the metal in the volume of grain – lamellar type with partially globularized plates of the α phase, plates of α-phase of close orientation form α colonies measuring 10–40 μs. The thickness of the α plates is 1–5 μs, between the plates or globules of the α phase there is a layer of β phase with a thickness of 1–2 μs. The microstructure of the deformed metal of titanium alloy VT3-1 consists of primary β grains, the volume of which contains colonies of lamellar α phases measuring 10–100 μs. The thickness of α plates is 1.5–3 μs, the layer of β phase in the intervals between α-plates is mainly 0.3–0.5 μs. The microstructure of semi-finished articles in the form of deformed bars of alloys VT9 and VT3-1 corresponds to type 4–6 according to the 9-type scale of the microstructure of instruction 1054-76. Studies of the mechanical properties of the obtained semi-finished articles have shown that they meet all the requirements of regulatory standards that are put forward by industry to the quality of the metal of heat-resistant titanium alloys
Assessing the value of the hydraulic friction factor in pipelines working with a flow connection along the path
Authors: Kravchuk Andriy , Cherniuk Volodymyr , Kravchuk Oleksandr , Airapetian Tamara
Published: November 2022

The results of an experimental study of the hydraulic friction factor of perforated pipelines that work with the collection of fluid along the path are reported. Clarification of this issue will make it possible to solve an important engineering task – to devise a reliable procedure for the hydraulic calculation of perforated pipes. The experiments were carried out on an assembled experimental bench. A steel pipeline with a perforated part of 1–3 m was investigated. Perforation holes were taken with a diameter of 3.6 and 9 mm. In the experiments, fluid flow, pressure loss, and average velocity were measured. Based on the data obtained, the values of the coefficient under study were calculated. It has been established that it is significantly larger than its values with uniform movement and is variable in length of the pipeline. Experimental dependences λcol on the value of the ratio of the velocities of the flowing jets of liquid to the average flow velocity in the corresponding section (Uh/V), as well as on the design characteristics of the channel, were obtained. It is shown that the lower value of the degree of pipe perforation corresponds to the higher values of λcol. This result can be explained by the influence of the attached flow rate on the main flow. The confirmation of this conclusion is the resulting shapes of diagrams of the average flow velocity obtained in the experiments, which differ significantly from standard diagrams with uniform motion. Obviously, additional energy is spent on the reformation of the velocities, and this causes additional head losses. Dependences were obtained for calculating the considered coefficient for prefabricated pipelines, including in the presence of transit flow rate. Their use in the calculation of the pipes under consideration will increase the reliability and efficiency of the sewage treatment plant, in which they are important structural elements
Obtaining and investigation of the chemical composition of powdered malt and polymalt extracts for application in the production of non-alcoholic functional beverages
Authors: Gadimova Natavan , Fataliyev Hasil , Allahverdiyeva Zulfiyya , Musayev Teymur , Akhundova Nazilya , Babashli Aynur
Published: November 2022

The group of consumer goods used in regular and daily nutrition, as well as the group of products that have a positive effect on the physiological functions of the body and have a certain chemical composition, should include processed beverages.
It is extremely important to expand the use of malt extracts in the creation of new non-alcoholic beverages, including functional ones. These extracts must come from sources other than typical malt forms, such as food grains and legumes (horse beans, buckwheat, peas, etc.). Buckwheat is a promising raw material for the production of beverages, especially without barley, wheat and rye gluten. To find the optimal parameters of primary mechanical, heat and moisture exchange processes by computer tests, it is required to develop a physical and mathematical method for grinding malt and mixed malt extracts. The aim of the study is to evaluate new malt extracts used in non-alcoholic beverages.
Beverages made from powdered malt and polymalt do not increase the intake of vitamins (B4) and minerals (potassium, calcium and magnesium) in the body, do not cure the deficiency of the nutrient dextrin. They have also not been shown to have a positive effect on physiological processes. The answer to this question lies in increasing the nutritional value of beverages by eliminating gluten, which has a negative effect on some physiological processes in the body. The studied powdered malt and polymalt extracts for functional beverages were evaluated theoretically and practically. The presented results showed that buckwheat extract powder can be used as an ingredient in beverages, as an independent product, and also as a product recommended for people with gluten intolerance
Development of diesel-oxygenated blends and exhaust gas recirculation impact on diesel engine’s performance and emission
Authors: J. Talib Lina , M. Salih Adel
Published: November 2022

Most research studies have focused on reducing NOx emitted from diesel engines by adding oxygenated fuels (such as alcohol and biodiesel) to diesel to prepare a good alternative to conventional diesel fuels. Biofuels produced from vegetable oil and waste cooking oil while alcohol can be produced from sugarcane and corn. In the current study, the biodiesel used in the tests was derived from waste cooking oil. In this study, the influence of adding Exhaust Gas Recirculation (EGR) to diesel, biodiesel (D80B20), diesel-pentanol (D85PEN15), diesel octanol (D90OCT10), diesel-propanol (D95PRO5) and diesel-biodiesel-pentanol (D50B40PEN10) blends on performance and emitted pollutants of a diesel engine was investigated. The practical experiments were divided into two parts, the first section comparing the results of using diesel and other fuels at different speeds 2100, 2400, 2700 and 3000 rpm at constant loads without EGR. The second section studied the effect of adding EGR in variable proportions (5 %, 10 %, 15 % and 20 %) to the studied fuel mixtures at constant loads and speed. The results showed that adding biodiesel to diesel (without EGR) increases brake specific fuel consumption, NOx and CO2 emissions by 13.66 %, 41.35 % and 30.49 %, respectively, but, the thermal efficiency of the brakes, exhaust gas temperatures, UHC and CO decreases at rates of 12.58 %, 10.22 %, 18.9 % and 21.31 %, respectively, compared to diesel. When EGR was added at 20 %, the maximum increase for D80B20, D95PRO5, ED100, and D85PENT15 was: 18.38 %, 24.60 %, 45.84 %, and 20 %, respectively, compared to when no EGR was added. The thermal efficiency, exhaust gases temperature and NOx levels decreased when EGR rate was raised
Point coordination mechanism based mobile ad hoc network investigation against jammers
Authors: Nourildean Shayma W. , Jasim Sabbar I. , Abdulhadi May T. , Jaber Mustafa Musa
Published: November 2022

In this paper, a jamming attack (a kind of Denial-of-Service attack) was investigated, which interfered with the normal operation of a Mobile Ad Hoc network, which is more vulnerable to various attacks because of its self-configuration, dynamic characteristics, therefore, jammers would affect the network QoS parameters by reducing the throughput and increasing the delay. This problem is solved in this study by enabling the Point Coordination Function, which is a media access mechanism specified by the IEEE standard in some selected MANET nodes (guard nodes) to improve the deficiency of MANET’s performance. The Riverbed modeler was utilized as a simulation tool. In this study, six jammers with two different transmission power values had been applied. In a number of different simulation scenarios with and without jammers, the estimated results showed that the jammers affected the network performance by increasing the delay to 3.0658 sec and decreasing the throughput to 120200.59 bits/sec. After enabling the PCF mechanism in a number of selected nodes, the results allowed the user to solve the problem by improving the network deficiency so that the throughput had been increased to 137478.32 bits/sec and the delay had been decreased to 0.7556 sec. It can be concluded that PCF is a good improvement for different levels of jammer transmission power such as 0.01 W and 0.001 W, and PCF also improved the network’s delay and throughput when the number of PCF enabled nodes had been increased to 10 nodes and 12 nodes, respectively. The improvement is also increased. This study can be used in practice for any ad hoc network when attacked by jammers
Development of gluten-free pasta products based on multivariate analysis
Authors: Kabylda Anar , Serikbay Guljanat , Myktabaeva Manshuk , Atanov Sabyrzhan , Muslimov Nurzhan , Tultabayev Mukhtar
Published: November 2022

The object of the study is the development of the formulation of gluten-free pasta using multivariate analysis. Celiac disease is a chronic disease characterized by damage to the small intestine mucosa by gluten, a plant protein found in cereals. Due to the growing incidence of celiac disease, it became necessary to provide patients with gluten-free products for life. One of the basic gluten-free products for people is pasta. Therefore, there is a need to expand the range of gluten-free pasta.
This development of gluten-free pasta provides for the use of combined flour mixtures from cereals.
According to the results of the study, comparison and analysis of 8 gluten-free pasta formulations developed and optimized using multivariate analysis, it was found that the sample G has the best organoleptic indicators. Based on the results of the “recipe-price” optimization of the sample G, the optimal ratios of pasta components in terms of the competitiveness of the final product were determined. It was found that the most balanced in organoleptic characteristics is gluten-free pasta (sample G) consisting of: corn flour – 33.51 %; rice flour – 22.24 %; xanthan gum – 2.94 %, water – 41.15 %, table salt – 0.09 %.
The results of the study can be useful in the development of pasta, taking into account the characteristics of the raw materials used, for consumers focused on food without allergenic proteins