bluuebunny/crossref_metadata_2025 huggingface dataset:
Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions
Authors: Chaudhary Anurag , Singh Kalpana , Verma Nishant , Kumar Sachin , Kumar Deepak , Sharma Prince Prashant
Published: April 2022

Chromenes are an important class of oxygen-containing heterocyclic compounds with intriguing biological activity, a simple structure with mild adverse effects. Chromenes are abundantly found in nature in the form of alkaloids, tocopherols, flavone, and anthocyanins. The Chromene nucleus is an important moiety for the discovery of new drug candidates. Chromene derivatives have shown various pharmacological activities like antiviral, anticancer, anti-inflammatory, antitumour, antimicrobial, antiproliferative, anticholinesterase, EPR-1 (Effector cell Protease Receptor-1) antagonist and MAO (Mono-Amine Oxidase) inhibitors. In SAR (Structure Activity Relationship) studies with chromene nucleus, it was found that 4-aryl moiety, 3-cyano group, and 2-amino group are essential for the cytotoxic activity. Substitution at the 7th position with electron donating group enhances the pharmacological activity whereas the electron withdrawing group decreases the pharmacological activity. Structural modifications at the chromene ring, middle aliphatic portion, and terminal aromatic ring yielded more potential 5-HT1A (5-Hydroxytryptamine 1A) receptor affinity and antidiabetic activity. Chromenes with cyclic secondary amine and 4-hydroxy phenyl substituents yielded potent antimicrobial compounds. This review summarizes the importance of chromenes in rational drug design and the development of novel molecules with a variety of pharmacological activities.
Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre
Retrospective Clinical Study; A National Survey in China
Authors: Wang Yongjun , Cao Yuting , Chen Ying , Zhang Xiaoli
Published: April 2022

Background:

Stroke is a serious disease that threatens human health both in China and
worldwide. Identifying and establishing its risk factors are prerequisites for intervention and evaluation
of prognosis. Over the years, risk factors, such as age, diabetes, and hypertension, have gradually
been established. However, at present, there is no consensus on the influence of sex on the prognosis
of ischaemic stroke.

Aims:

The aims of our research was to analyse the correlation between sex and poststroke prognosis
based on the results of the Third China National Stroke Registry [CNSR-III], as well as the influence
of other risk factors that may be confounded by sex on ischaemic stroke and potential interventions.

Methods:

The CNSR-III recruited 14146 acute ischaemic stroke [AIS] patients between 2015 and
2018. Our study included 13,972 patients who had complete follow-up information. This research
analysed basic information, socioeconomic status, lifestyle habits, medical history, and poststroke
prognosis.

Results:

There was a conspicuous relationship between sex and functional prognosis, stroke recurrence
and all-cause death due to ischemic stroke in univariate analysis. Male stroke patients had a
better prognosis than female patients. In multivariate analysis, we found that age, atrial fibrillation
[AF], diabetes, hypertension and the severity of stroke had adverse effects on ischemic stroke prognosis.
After adjustment for other risk factors, the functional prognosis of female patients at 3 months
was worse than that of male patients [odds ratio [OR] 1.16, 95% confidence interval [CI], 1.025-
1.314]. Sex had a nonsignificant association with stroke recurrence at 3 months [hazard ratio [HR]
1.141, 95% CI, 0.975-1.336]. Furthermore, compared to male patients, female stroke patients had a
lower cumulative death rate at 12 months [HR 0.777, 95% CI, 0.628-0.963].

Conclusion:

Our study identified sex differences in stroke-related disability, recurrence, and death
and attempted to explain the causes of these differences. Our study clearly showed that a large proportion
of this difference could be attributed to age, socioeconomic factors, lifestyle habits, and
medical history, confounded by sex differences rather than sex per se.
Targeting the HIV-1 Tat and Human Tat Protein Complex through Natural
Products: An In Silico Docking and Molecular Dynamics Simulation
Approach
Authors: Kumar Vipin , Mishra Ayushi , Singh Vinay Kumar , Singh Anchal
Published: April 2022

Background:

Tat protein is considered essential for substantial HIV-1 replication, and is also
required to break HIV-1 latency, resulting in productive HIV replication. The multifaceted regulatory role
of HIV Tat and the fact that it is expressed in the early stages of HIV infection justify its potential as an
anti-HIV drug target.

Objective:

The present study was undertaken with the aim to target HIV-1 Tat protein with natural compounds
which could help in identifying potential inhibitors against HIV-1 Tat.

Methods:

In this study, we compared the binding of Tat protein and Human P-TEFb Tat protein complex
(TPC) with phyto-steroids and terpenes to evaluate their potential for HIV-1 treatment. The docking ability
of plant products with HIV-1 Tat and TPC was studied with respect to dissociation constant, geometric
shape complementary score, approximate interface area, and binding energy using Patch dock and
YASARA. Molecular dynamics simulation was set up to investigate the interactions of the natural compounds
with Tat protein and human tat protein complex (TPC).

Results:

The binding energy and dissociation constant of Diosgenin, Catharanthine and Ginkgolide A
with Tat and TPC were comparable to antiretroviral drugs, Maraviroc and Emtricitabine. The natural
products, Diosgenin, Ginkgolide A and Catharanthine, showed the highest binding energy and were stable
with Tat protein and TPC in the entire MD simulation run.

Conclusion:

The natural products, Diosgenin, Ginkgolide A and Catharanthine, showed highest binding
energy and were stable with Tat protein and TPC in the entire MD simulation run. The binding energy
and dissociation constant of Diosgenin, Catharanthine and Ginkgolide A with Tat and TPC were comparable
to antiretroviral drugs, Maraviroc and Emtricitabine.
Safety and Effectiveness of Sorafenib in the Treatment of Advanced Hepatocellular
Carcinoma
Authors: Vijayan Meenu , Prasanthan Ardra Thottarath , Raju Dona , Vinayakumar Syamaprasad Thachethukunnil , Jacob Mary , Chandran Anand , Keechilatu Pavithran
Published: April 2022

Background:

Hepatocellular carcinoma (HCC) is the most prevalent kind of primary liver
cancer and a significant cause of cancer-related mortality across the world. Sorafenib is considered
the approved drug of choice in advanced HCC, which is an oral multikinase inhibitor with effective
antiproliferative and antiangiogenic effects. In India, there is currently insufficient data on the safety
and efficacy of sorafenib in the treatment of HCC.

Objective:

The study aims to evaluate the safety and effectiveness of sorafenib therapy in advanced
HCC.

Methods:

A prospective study of 66 patients administered with sorafenib for advanced HCC
between June 2016 and May 2017 was carried out in a single center with a mean follow-up of 3
months. The adverse events (AEs) were graded using the Common Terminology Criteria for
Adverse Events (CTCAE), version 4.0. Effectiveness was analyzed based on alpha-fetoprotein
(AFP) levels from laboratory findings. The median age was 63 years (range 61-70), with the male to
female ratio of 16:1.

Results:

The most commonly observed adverse events were fatigue (31.81%), hand-foot syndrome
(24.24%), and diarrhea (24.24%). A statistically significant decline in AFP levels was observed with
sorafenib treatment (p= <0.001).

Conclusion:

Sorafenib appears to be beneficial for individuals with advanced HCC, regardless of the
baseline condition.
Enhancement of Drug Penetration Rate by Enriching Skin Hydration: A
Novel Amalgamation of Microemulsion and Supersaturation
Authors: Chavda Dipika , Shukla Atindra , Soni Tejal
Published: April 2022

Background:

The evolving need and facilitation of topical formulations have risen in the
present era. Topical industries are continually striving to satisfy patients with newer and innovative
products. However, dry skin is the critical factor contributing to drug penetration into the skin.

Objective:

The current research aims to develop cost-effective and commercially feasible industrial
scale microemulsion of wheat germ oil to enrich skin hydration, enhancing the drug permeation rate.

Methods:

The Pseudo-ternary phase diagram was constructed for screening of microemulsion components.
Wheat germ oil containing O/W microemulsion was prepared and evaluated for physicochemical
parameters, thermodynamic stability study, globule size determination, enhancement of skin hydration,
and skin permeation rate by ex vivo study.

Results:

The wheat germ oil containing microemulsion was prepared by incorporating tween 20 [surfactant]
and ethanol [co-surfactant]. All physicochemical parameters were in the ideal range. Following
the thermodynamic stability study, the TEM study showed globule size of optimized microemulsions
in the range of 69.64 nm to 84.42 nm. The skin moisture tester showed a high hydration level for
more than eight hours. An Ex vivo study revealed higher drug flux [Jss] of Pomegranate peel Extract
[17.99 μg/cm2/h] with an enhancement ratio of 1.69.

Conclusion:

The topical formulation application has become challenging for researchers due to the
skin's dryness and lower water content. However, the developed WGO microemulsion aids more penetration
and is helpful in achieving higher drug flux. In addition, it is a cost-effective, easy to prepare,
and patient-friendly drug delivery system.
Nurse-led and Interdisciplinary Secondary Cardiovascular Prevention
Programmes: Spanish Cohort of the EUROACTION Project
Authors: Buigues Cristina , Trapero Isabel , Velasco Jose Antonio , Salvador-Sanz Antonio , Jennings Catriona , Wood David , Queralt Ana
Published: April 2022

Background:

Cardiovascular prevention and rehabilitation programmes (CVPRP) are a
preventive tool, which can reverse unhealthy behaviours and improve risk factor management.
They have been successfully implemented in a variety of settings in patients with coronary heart
disease (CHD).

Objective:

The objective of this study is to evaluate an interdisciplinary and nurse-led
cardiovascular prevention and rehabilitation programme in patients with coronary heart disease.

Method:

Six pairs of hospitals were randomised between intervention (INT) and usual care (UC)
patients. The interdisciplinary team in the intervention hospital carried out a 16-week CVPRP to
reach European risk factor goals. The trial is registered as ISRCTN 71715857.

Results:

The proportion of patients achieving European cardiovascular recommendations in Spain
increased in the intervention hospital, mainly regarding fruit and vegetable consumption (INT 98%
vs. UC 53%, p<0.001), oily fish consumption (INT 42% vs. UC 19.5%, p<0.001), self-reported
physical activity (INT 31% vs. UC 12.4%, p=0.04), blood pressure (INT 69% vs. UC 47.1%) p<
0.05) and LDL concentrations (INT 86.1% vs. UC 67.6%, p=0.04).

Conclusion:

The EUROACTION nurse-led model of CVPR programme has shown that
therapeutic goals in cardiovascular disease prevention are affordable and sustainable in everyday
clinical practice. EUROACTION model adapted in Spain has produced a healthier lifestyle.

Clinical Trial:

Trial registration No. ISRCTN 71715857.
Interventions to Promote Rehabilitation Programmes for Youth with Violent Behaviours in Limpopo Province: A Systematic Literature Review
Authors: Ramakulukusha Tshilidzi O. , Babalola Sunday S. , Mashau Ntsieni S.
Published: April 2022

Background:

A rehabilitation strategy aims to reshape the individual and prepare them to enter society with a different state of mind and start a new life after incarceration.

Objective:

The purpose of this systematic literature review was to identify and describe the intervention strategies to promote rehabilitation programmes for youth with violent behaviours, guided by Rodger’s evolutionary concept analysis framework.

Methods:

A comprehensive database search was conducted from 2010 to 2020. The review focused on quantitative and qualitative studies and reports obtained from GOOGLE SCHOLAR, SABINET, SAGE, EBSCO-HOST, and SCIENCE DIRECT. Keywords and search strategies were also taken into consideration. The researchers systematically reviewed the literature, and 250 articles and 25 reports were obtained; their content was screened for relevance, and 50 articles and 11 reports were found to be suitable and relevant; these were then reviewed. A thematic analysis was performed to identify antecedents, attributes, and consequences of rehabilitation on youth with violent behaviours. The study findings were then used to inform the development of the conceptual framework.

Results:

The results show that antecedents of these rehabilitation strategies on violent youth behaviours include family structure, increased bullying due to gangs, and gender and environmental factors. The identified attributes were motivation, contextual differences, transformation, opportunity, and ineffective rehabilitation programmes in addressing violent behaviours in youths.

Conclusion:

Youth is regarded as the most vulnerable group in society, holding a high percentage of the population. As a result, it is always vital to protect them.
Optimization of Site-exploration Programs in Slope Designs Using 3D
Conditional Random Fields
Authors: Ou-Yang Jia-Yi , Liu Yong , Chen Guan
Published: April 2022

Background:

In situ soil properties exhibit inherent spatial variability, which is often
described by a 3D random field. Soil properties at particular portions are available by site investigation.
Wider site investigation scope provides a more accurate description of the geologic profile.
However, limited by budget, choosing an effective site exploration scope is of significance.

Objective:

This study introduces a framework to determine the optimal site investigation strategy in
the 3D domain, which yields the lowest mean risk of slope designs.

Method:

The mean risk of slope designs is considered to be a function of the costs of site investigation,
under-design, and over-design. The unconditional random fields are generated by the spectral
representation method initially. Subsequently, the sampled data are incorporated into the random
fields via the Kriging algorithm, and the conditional random fields are simulated. A 3D undrained
slope is evaluated for illustration.

Results:

The effects of sampling locations and spacing on the risk of slope designs are examined.
The results indicate that the optimal sampling location is close to the zone where slope failure may
occur. Moreover, there exists an optimal sampling spacing that minimizes the mean risk of slope
designs.

Conclusion:

This investigation can provide guidance for determining the optimal site exploration
programs on the 3D domain with knowledge of the associated risks.
Natural Approach in Osteoarthritis Therapy
Authors: Grigore Alice , Vulturescu Virginia
Published: April 2022

Osteoarthritis (OA) is the most common joint disease worldwide, and its rising prevalence is supported by factors such as obesity and sedentariness. At the molecular level, it is considered an inflammatory disease that leads to the destruction of articular cartilage. Effective therapy to end the degenerative process of arthritis remains elusive, and most therapeutic tools prevent the progress or alleviate the symptoms. By now, medicines for OA are available for oral, topical, or intra-articular (IA) therapy and include analgesics, nonsteroidal anti-inflammatory drugs, corticosteroids, and hyaluronic acid. Compared with conventional oral administration, IA therapy has multiple advantages in terms of bioavailability, efficacy, and toxicity. This review aims to study the underlying beneficial effects of herbal medicine in OA therapy and to open new research perspectives. Herbal medicine administered orally or topically exhibits pharmacological properties that could be relevant for their beneficial effect in OA, mainly anti-inflammatory and antioxidant effects. There are few studies regarding IA injections of plant extracts/ compounds and none related to any combination with agents already used in the clinic. Designing natural pharmaceutical formulations with increased bioavailability that are safe, lack side effects, and are specifically tested, would be a plus for research on medicinal plants and a novelty for the clinic.
IMPLEMENTASI KEBIJAKAN KARTU INDONESIA PINTAR (KIP) DALAM UPAYA MENGURANGI ANAK PUTUS SEKOLAH DI SMP N 1 PONCOWARNO
Authors: Saputri Vikin Ade
Published: April 2022

The Smart Indonesia Card Policy in reducing the number of children who drop out of school is not optimal. The purposes of this research are to describe: 1) The implementation of the Smart Indonesia Card Policy in reducing the number of children who drop out of school at SMP N 1 Poncowarno, 2) The impact of the implementation of the Smart Indonesia Card in an effort to reduce the number of children who drop out of school at SMP N 1 Poncowarno, and 3) Factors that support and hinder the implementation of KIP policies at SMP N 1 Poncowarno.This research uses a descriptive qualitative approach. Data collection techniques are interviews, observation and documentation. The subjects of this research were staff of the Kebumen district office planning, school principals, school KIP managers, students of KIP recipient, parents of KIP recipients, and students who had dropped out of school. The data analysis technique used Milles and Huberman’s model, namely interactive analysis. The data validity used source and technique triangulation.The results showed: 1) Smart Indonesia Cards are communicated through regular socialization. Supporting equipment resources are computers and Wi-Fi. The number of managers at school is deemed insufficient. School plays a role as the person in charge. 2) KIP has not maximally reduced APS. 3) Supporting factors: good communication, coordination, socialization and cooperation among policy implementers, as well as supporting facilities. The inhibiting factors are lack of management personnel, student negligence and not being on target. Keywords: Policy Implementation, Smart Indonesia Card, children who drop out of school
EVALUASI SISTEM REAL TIME ONLINE DALAM PROGRAM PENERIMAAN PESERTA DIDIK BARU DI DINAS PENDIDIKAN KOTA YOGYAKARTA
Authors: Firlani Heru Dyah
Published: April 2022

This study aims to describe the evaluation of the Real-time Online system in the new student admission program at the Yogyakarta City Education Office. The method in this study is a qualitative descriptive study with the CIPP evaluation model. The data collection techniques used in this study are documentation, interviews, and observations. The research data were analyzed using the Miles and Huberman model. The validity test of the data used triangulation of sources and techniques. The results of the study show that: (1) Context aspect, policies for implementing the new student admission program with the Real-Time Online system in the Yogyakarta City Education Office are relevant and have referred to Yogyakarta Mayor regulation number 24 of 2018. (2) Input aspect, the availability of human resources has been fulfilled. The completeness and feasibility of infrastructure are still lacking, such as a network that had problems. (3) The process aspect, the implementation of the program is by following the guidelines for the admission of new students to the education, it is being objective, accountable, transparent, and non-discriminatory. (4) Aspects of results, the data of students who register with the capacity for elementary schools have been met, however, for junior high school there are still empty seats.  Keywords: real time online system, the new students admission
KONSTRUKSI KELUARGA PADA PELAKSANAAN PEMBELAJARAN DARING SELAMA PANDEMI COVID-19 DI DESA CIBANGKONG KABUPATEN BANYUMAS
Authors: Agusty Awalia Hening
Published: April 2022

This study aims: to describe how families construct online learning policies are reviewed from the differentiation of economic background as well as supporting factors and inhibitory factors. The research approach uses descriptive qualitative. The subjects of the study were parents who had primary school-age children. Data collection techniques using observations, interviews, documentation. The data is analyzed using interactive methods. The validity of the data is tested by triangulation techniques and source triangulation. The results of the study: (1) Family construction on online learning, parents with upper-middle economic level can access education easily, while parents with lower economic levels have difficulty in accessing education. Parent role: Pre-learning: not playing an active role, Learning implementation: active role, Post-Learning: passive-active. (2) Supporting factors: availability of online learning tools, availability of WiFi as internet source, including tutoring children, support from family. Inhibitory factors: inadequate facilities, teacher's lack of creativity in designing online learning, changes in the learning environment make children lose learning motivation, lack of parental knowledge. Keywords: Family Construction, Economic Background, Online Learning
STRATEGI IMPLEMENTASI KEBIJAKAN UNTUK PENINGKATAN KESEJAHTERAAN GURU SD HONORER DI KABUPATEN BANTUL
Authors: Anggraeni Indah Yulistiya
Published: April 2022

This study aims to describe policies, policy implementation strategies, constraints, and efforts to overcome obstacles in implementing policy implementation strategies to improve the welfare of honorary elementary school teachers in Bantul Regency. This research is a qualitative descriptive study. Data analysis used an interactive model. Test the validity of the triangulation technique and source data. The results of the study explained that the government, local government and schools in Bantul Regency established and implemented a series of policies to improve the welfare of honorary elementary school teachers, including: provision of regional incentives, certification, BOS, and PPPK procurement. The local government through the Bantul Education Office and SDN 1 Bantul and SD Unggulan Aisyiyah implement policy implementation strategies: (1) Bantul Education and Youth Organization: coordinate with the Regional Government in an effort to increase incentives and recruit new honorary teachers who receive regional incentives, (2) SDN 1 Bantul and SD Unggulan Aisyiyah implement regional and school policy strategies are in accordance with predetermined policy administration procedures. In implementing the strategy, each institution faces internal and external obstacles and has its efforts to improve the welfare of Honorary Elementary School teachers in Bantul Regency. Keywords: the welfare of honorary primary school teachers
IMPLEMENTASI PENDIDIKAN BERBASIS BUDAYA DI SEKOLAH MENENGAH ATAS NEGERI 2 WATES
Authors: Wahyuni Tri
Published: April 2022

This study aims to describe: (1) the implementation of culture-based education in SMA Negeri 2 Wates; (2) Supporting and inhibiting factors in the implementation of culture-based education at SMA Negeri 2 Wates. This research is a qualitative descriptive study. Data collection techniques using observation, interviews, and documentation. Analysis of the interactive model data from Milles and Huberman. Test the validity of the data by triangulation of sources and techniques. The results of the research are: (1) Implementation of culture-based education: a) application of the vision, mission and goals of the school; b) adjustments to the curriculum, lesson plans and syllabus of subjects; c) 5S cultural habituation and environmental insight; d) school activities: Kartini's day, school anniversary, ketoprak, work shows, Thursday pahing; procurement of books with cultural insight, and competition in the arts; e) conditioning of school infrastructure and environment; f) extracurricular activities; g) cooperate with the Kulon Progo Cultural Office. (2) Supporting factors: official support, enthusiasm and high commitment from school members, the existence of supporting programs, and the availability of adequate facilities. Inhibiting factors: student responses that show less enthusiasm, changing student interest and low level of understanding, as well as cultural-based educational activities that coincide with other activities. Keywords: policy implementation, culture-based education, SMA Negeri 2 Wates
FAKTOR-FAKTOR DETERMINASI KEPUTUSAN ORANG TUA MEMILIH SEKOLAH DASAR SWASTA UNTUK ANAK DI KOTA YOGYAKARTA
Authors: Pracipta Kurnia Indah
Published: April 2022

Penelitian ini bertujuan untuk mengetahui faktor-faktor determinasi keputusan orang tua dalam memilih sekolah dasar swasta untuk anak di Kota Yogyakarta. Penelitian ini merupakan penelitian kuantitatif di tiga sekolah swasta di Kota Yogyakarta. Subyek penelitian adalah orang tua. Teknik pengumpulan data berupa kuesioner. Teknik analisis data untuk menguji instrumen validitas item menggunakan uji coba validitas isi statistik Aiken’s V dengan jumlah rater sebanyak 5 orang. Sedangkan untuk teknik analisis data berupa validitas, reliabilitas dan uji hipotesis penelitian dilakukan dengan bantuan software Lisrel 8.8. Hasil penelitian menunjukkan semua variabel faktor dalam penelitian mendeterminasi keputusan orang tua dalam memilih sekolah dasar swasta untuk anak. Namun, hanya terdapat 6 faktor yang dominan mendeterminasi keputusan orang tua yakni faktor yaitu tenaga pendidik, kualitas pengajaran, basis sekolah, budaya sekolah, citra sekolah dan fasilitas sekolah. Sedangkan faktor biaya sekolah, lokasi sekolah dan faktor tingkat pendidikan orang tua tidak menjadi prioritas yang mendeterminasi keputusan orang tua.
IMPLEMENTASI NILAI KEDISIPLINAN SISWA SD MUHAMMADIYAH WONOKROMO II PADA MASA PANDEMI COVID-19
Authors: Prabowo Fanny Berliana
Published: April 2022

Penelitian ini bertujuan untuk mendeskripsikan proses implementasi serta faktor pendukung dan penghambat dari pelaksanaan nilai kedisiplinan siswa SD Muhammadiyah Wonokromo II pada masa pandemi Covid-19. Penelitian ini didasarkan pada teori implementasi kebijakan menurut Van Metter dan Van Horn. Penelitian ini menggunakan metode kualiatif dengan jenis penelitian studi kasus yang bersifat deskriptif. Hasil penelitian yang diperoleh yaitu: (1) Implementasi nilai kedisiplinan siswa SD Muhammadiyah Wonokromo II: a) Standar pelaksanaan nilai kedisiplinan di masa pandemi adalah adanya Peraturan dan Kebijakan dari Kepala Sekolah dalam mengikuti Pembelajaran Jarak Jauh. Tujuan dari kebijakan ini untuk menanamkan nilai kedisiplinan pada diri anak, agar sifat disiplin melekat pada diri anak, khususnya di masa pandemi Covid-19 ini kedisiplinan terhadap protokol kesehatan sangat perlu diterapkan sebagai upaya untuk mencegah terjadinya penularan virus corona. b) Sumber daya yang dimiliki yaitu Kepala Sekolah, Guru, Siswa, Orangtua, dan Masyarakat, serta fasilitas yang memadai. c) Karakteristik organisasinya selalu berkomitmen untuk disiplin, khususnya pada masa pandemi seperti ini. d) Disposisi tercermin dari karakteristik agen pelaksana. e) Hubungan antar organisasi berjalan dengan adanya komunikasi dan koordinasi. f) Kondisi lingkungan baik dan selalu mendukung. (2) Faktor pendukungnya adalah adanya komunikasi dan kerjasama yang baik antar keluarga, sekolah, dan masyarakat serta adanya reward untuk selalu memotivasi. Sementara itu, faktor penghambatnya a) adanya siswa yang pasif dan kurang disiplin dalam mengikuti pembelajaran daring. b) kendala sinyal kurang bagus dan tidak adanya handphone. Kata kunci: Implementasi, Nilai Kedisilinan Siswa, Pandemi Covid-19,SD Muhammadiyah Wonokromo II.
KEBIJAKAN SEKOLAH BUDAYA DI SD NEGERI 1 TRIRENGGO BANTUL
Authors: Ramadhan Rai Asmara
Published: April 2022

AbstrakPenelitian ini bertujuan untuk mendiskripsikan latar belakang dan implementasi kebijakan sekolah budaya di SD Negeri 1 Trirenggo. Penelitian ini merupakan penelitian deskriptif kualitatif. Penelitian ini dilaksanakan di SD Negeri 1 Trirenggo pada bulan Maret sampai April. Subjek penelitian ini yaitu kepala sekolah, guru, dan siswa. Teknik pengumpulan data menggunakan observasi, wawancara dan studi dokumen. Hasil penelitian menunjukkan bahwa: (1) latar belakang kebijakan sekolah budaya karena ingin melestarikan nilai budaya luhur dan kearifan lokal. Proses perumusan kebijakan sekolah budaya didominasi kepala sekolah dengan merumuskan tujuan dan perencanaan lalu disosialisasikan kepada guru, bersama-sama menyusun silabus dan RPP, dijabarkan programnya dan terlihat respon dari siswa; (2) implementasi kebijakan sekolah budaya yaitu adanya rapat, seminar, menunjuk koordinator program, guru paham mengintegrasikan RPP, program pengintegrasian, kegiatan sekolah dan pembiasaan. Faktor pendukung yaitu, guru, wali murid, pihak ketiga, fasilitas, dan kejelasan program. Sedangkan faktor penghambatnya seperti, SDM kurang terlatih, banyaknya kegiatan, ekonomi wali murid, dan lingkungan. Kata kunci: Kebijakan, Sekolah Budaya, Sekolah Dasar AbstractThis study aims to describe the background and implementation of cultural school policy in Public Elementary School 1 Trirenggo. The type of this research is qualitative descriptive. The research was conducted in 1 Trirenggo State Elementary School from March to April. The subject of this study is the Principal, teachers, and students. The results showed that: (1) the background of cultural school policy because they want to preserve noble cultural values and local wisdom. The formulation process of cultural school policy dominated by the Principal from formulating goals and planning then socialized to the teachers, together arranged syllabus and lesson plans, spelled out the program, and responses appear from students; (2) the implementation of cultural school policy is briefings, seminars and appoints a program coordinator, the teacher interprets lesson plan, integrative programs, school activities and habituation. Supporting factors such as teachers, parents, third parties support, facilities, and detailed program. While the inhibiting factors such as, human resources, to many activities, economic parents, and the environment. Keywords: Policy, Culture School, Elementary School.
IMPLEMENTASI KEBIJAKAN KAMPUNG RAMAH ANAK DI KELURAHAN GUNUNGKETUR KOTA YOGYAKARTA
Authors: Yudhistira Muhammad Arya Daffa
Published: April 2022

Abstrak Penelitian implementasi kebijakan kampung ramah anak di Kelurahan Gunungketur Kota Yogyakarta bertujuan mendeskripsikan implementasi kebijakan kampung ramah anak di Kelurahan Gunungketur Kota Yogyakarta. Penelitian ini merupakan penelitian kualitatif deskriptif. Teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Teknik analisis data menggunakan metode Miles, Huberman, dan Saldana Uji keabsahan data pada penelitian ini menggunakan metode triangulasi sumber. Hasil dari penelitian ini adalah (1) Implementasi kebijakan kampung ramah anak di Kelurahan Gunungketur Kota Yogyakarta dilakukan melalui pembentukan komitmen masyarakat serta kebermitraan dengan lembaga terkait. Aktor yang berperan yakni kelurahan, rt dan rw, Gugus tugas KRA, masyarakat serta lembaga mitra KRA. (2) Program dari kebijakan kampung ramah anak mencakup kegiatan pemanfaatan waktu luang yaitu pendidikan kesenian kebudayaan, serta program dari lembaga pusat kreatifitas anak di masing-masing rw. (3) Faktor pendukung yaitu dukungan orangtua terhadap kegitan anak, peran serta aktif pengelola menjalankan program. Faktor penghambatnya adalah kurangnya partisipasi orangtua, serta kurangnya pendanaan terhadap program.Kata Kunci: Kampung Ramah Anak, Implementasi, Penerapan Program  AbstractThe study about the implementation of child-friendly village in gunungketur urban village yogyakarta aims to describe the implementation fo child-friendly village in gunungketur urban village yogyakarta. This research use qualitative descriptive. The subject in this study were the headman of urban village, the policy task force,the management of related institution as well as public. The data obtained with interviews, observation and documentation. Data analysis techniques use Miles, Huberman, and Saldana model. The results of the study are : (1) The implementation of child-friendly village in gunungketur urban village yogyakarta done by forming public commitments and partnership with related institutions. The actor who plays a role in the policy were the urban village administrator, the officer, the policy task force, the public as well as policies related institutions. (2) The child-friendly village programs include leisure time utilization activities such cultural arts education and the program by the central agency of children’s creativity institution in each region. (3) The supporting factors in children-friendly village policy implementation is the support form parents for their children activities, and the active role of the manager in carrying out the programs. The obstacle factors is lack of participation from the parents in the activities, as well as lack of funding for the programs. Keywords : Child-friendly village, Implementation, program aplication.
IMPLEMENTASI KEBIJAKAN PENERIMAAN PESERTA DIDIK BARU (PPDB) SISTEM ZONASI PADA JENJANG SMP NEGERI DI KOTA YOGYAKARTA
Authors: Kussetyaningsih Retno
Published: April 2022

AbstrakPenelitian ini bertujuan untuk untuk mendeskripsikan implementasi kebijakan Penerimaan Peserta Didik Baru (PPDB) sistem zonasi pada jenjang SMP Negeri di Kota Yogyakarta serta mengetahui faktor pendukung dan faktor penghambat dalam implementasi kebijakan tersebut. Penelitian ini menggunakan pendekatan kualitatif metode deskriptif. Pengumpulan data dilakukan melalui wawancara dan studi dokumentasi. Teknik analisis data interaktif Miles Huberman. Adapun tekik keabsahan data menggunakan triangulasi sumber dan teknik. Hasil penelitian ini menunjukan Implementasi Kebijakan PPDB  secara teknis berjalan lancar, hal ini didukung oleh penggunaan sistem daring dan kebijakan yang jelas. Keberhasilan PPDB sistem zonasi berdampak pada peningkatan perluasan kesempatan bagi masyarakat Kota Yogyakarta pada usia sekolah untuk mengenyam pendidikan. Faktor pendukung pelaksamaan PPDB adalah dataup to date dan petunjuk teknis yang jelas, sedangkan faktor penghambatnya diantaranya masih kurangnya sosialisasi, kecurangan administrasi yang dilakukan oleh oknum orangtua, serta persebaran sekolah yang tidak merata Kata kunci: Pendidikan, Implementasi, Kebijakan PPDB Zonasi AbstractThis aims of this research is to describe the implementation of  zoning system for the New Student Admissions (PPDB) policy at the State Junior High School in Yogyakarta and to determine the supporting and inhibiting factors in implementing the policy. This study is using a qualitative approach with a descriptive method. The data collection was carried out through interviews and documentation study. Miles Huberman models is using for analyse the data. The validity of the data used triangulation of sources and techniques. The results of this research indicate that the implementation of PPDB policies is technically running smoothly, this is supported by the use of an online system and clear policies. The success of the PPDB zoning system has an impact on increasing the expansion of opportunities for the people of Yogyakarta at school age to get education. The supporting factor for PPDB implementation is data up to date and clear technical instructions, while the inhibiting factors include the lack of socialization, administrative fraud committed by parents, and the uneven distribution of schools Keywords: Education, Implementation, PPDB Zoning Policy
KETERCAPAIAN STANDAR NASIONAL PENDIDIKAN TINGKAT SEKOLAH DASAR DI KECAMATAN GEDONGTENGEN
Authors: Herlambang Agung Feby
Published: April 2022

AbstrakPenelitian ini bertujuan untuk mendeskripsikan tingkat ketercapaian Standar Nasional Pendidikan yang ada pada Sekolah Dasar se-Kecamatan Gedongtengen, Yogyakarta. Jenis Penelitian yang digunakan adalah penelitian kuantitatif deskriptif. Tempat penelitian dilakukan di Kecamatan Gedongtengen Yogyakarta. Jumlah populasi sebanyak enam SD yang ada di Kecamatan Gedongtengen, yaitu; SD Negeri Gedongtengen, SD Negeri Sosrowijayan, SD Kanisius Notoyudan, SD Muhammadiyah Pringgokusuman, SD Netral C dan SD Netral D. Teknik pengumpulan data menggunakan angket instrumen baku akreditasi dari BAN-SM Tahun 2019. Teknik analisa data menggunakan statistik diskriptif dengan metode penyajian grafik dan tabel. Hasil dari penelitian ini menunjukkan bahwa skor capaian rerata seluruh standar pada semua sekolah sebesar 95,76 maka telah mencapai kriteria unggul. Namun masih ditemukan permasalahan dalam beberapa komponen standar, maka dari itu masih memerlukan upaya akselerasi serta inisiatif dari sekolah dan semua pihak yang terkait dengan berbagai bentuk kegiatan dan program evaluatif untuk meningkatkan capaian Standar Nasional Pendidikan Sekolah Dasar di Kecamatan Gedongtengen.Kata Kunci : Ketercapaian, Standar Nasional Pendidikan, SD se-Kecamatan Gedongtengen YogyakartaAbstractThis research aims to describe the level of attainment of the National Education Standards in Elementary Schools in Gedongtengen District, Yogyakarta. The type of research used is descriptive quantitative research. The research site was conducted in Gedongtengen District, Yogyakarta. The total population is six elementary schools in Gedongtengen District, namely; Gedongtengen Elementary School, Elementary School Sosrowijayan, SD Canisius Notoyudan, SD Muhammadiyah Pringgokusuman, SD SD Neutral Neutral C and D. The data collection technique using questionnaires raw instrument accreditation from BAN-SM Year 2019. Data analysis using descriptive statistical methods and presentation graphics table. The results of this study indicate that the average achievement score of all standards in all schools is 95.76, so it has reached the superior criteria. However, problems are still found in several standard components, therefore it still requiresefforts accelerationand initiatives from schools and all parties related to various forms of activities and evaluative programs to improve the achievement of National Elementary Schools Education Standards in Gedongtengen District.Keywords: Achievement, National Education Standards, Elementary Schools in Gedongtengen Yogyakarta District
Mind-Body Interactions Across the Menstrual Cycle Phases: A Systematic Review
Authors:   Sigmund Freud University, Milan, Ripa di Porta Ticinese 77, Italy, Borlimi Rosita , Riboli Greta ,   Sigmund Freud University, Milan, Ripa di Porta Ticinese 77, Italy,   Sigmund Freud University, Wien, Psychology Department, Sigmund Freud Platz 1, Austria, Nese Mattia ,   Sigmund Freud University, Milan, Ripa di Porta Ticinese 77, Italy, Buattini Matilde ,   Sigmund Freud University, Milan, Ripa di Porta Ticinese 77, Italy, Colombardo Marella ,   Sigmund Freud University, Milan, Ripa di Porta Ticinese 77, Italy, Brighetti Gianni ,   Sigmund Freud University, Milan, Ripa di Porta Ticinese 77, Italy
Published: April 2022

The length of the menstrual cycle (MC) varies among women, with an average regularity between 21 and 40 days. Six temporal frames can be observed within the monthly cycle, based on the fluctuations of the hormone levels. These fluctuations are accompanied by alterations in the central nervous system (CNS) and autonomic nervous system (ANS) and can be quantified using psychophysiological techniques. In this systematic review, we discussed the studies conducted with healthy females that examined aspects associated with the functions of the ANS and the CNS, including psychological, emotional, behavioral, hormonal, and perceptive variables, relating their possible changes and alterations to different phases of the MC. The PubMed and EBSCO databases were searched for articles published between January 2010 and September 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was applied. A total of 64 studies investigating ANS and CNS or perceptual systems across the MC were included in this review. Several studies found more alterations in the heart rate variability components during the days following ovulation compared to the days of the follicular phase. Behavioral alterations included a decrease in the percentage of REM sleep during the mid-luteal phase and an increase in calorie intake during the late-luteal phase compared to that in the follicular phase. Additionally, the reward system was found to be engaged to a greater extent during the luteal phase than during the follicular phase. The results differed considerably for many cognitive, behavioral, and autonomic variables. No significant alterations were found in most perceptual systems. A variegated picture emerged from the results of the various studies that applied different methodologies and measurements. The results suggested a new methodology that uses the temporal dimension for investigating the interactions between biological systems and psychological effects.
The Impact of Platelet-Rich Plasma on Polypropylene Mesh Implanted in Vesicovaginal Space of Hypoestrogenic Rabbit Model: Analysis of Mesh-Tissue Integration (Preprint)
Authors: Meutia Alfa Putri
Published: April 2022

BACKGROUND

Mesh-augmented surgery with polypropylene mesh (PPM) is often used in urogynecology and pelvic reconstructive surgery. However, various complications arising from its integration process cause a decrease in number of mesh-augmented surgery performed worldwide. An approach to improve mesh-tissue integration is by coating PPM with anti-inflammatory and wound healing molecules such as platelet-rich plasma (PRP) which is part of biotechnologies capable of accelerating wound healing. Estrogen is also known to have beneficial effect in wound remodelling, therefore hypoestrogenic status may have negative implication on wound healing. The mechanism of how PRP play a role in wound remodelling especially in hypoestrogenic state has not been fully described until now.

OBJECTIVE

The aim is to investigate the impact of platelet-rich plasma application to polypropylene mesh in hypoestrogenic rabbits model.

METHODS

This is a randomized controlled trial on hypoestrogenic rabbit model. Samples were categorized into either PRP or PPM groups (1:1 ratio) with a minimum sample size of 16 in each arm using simple random sampling. All samples were put into hypoestrogenic state by bilateral oophorectomy. After confirming the decrease of estradiol level, the mesh was implanted in vesicovaginal space. The samples were euthanized on either the 7th, 14th, 28th, or 90th day of the surgery. The mesh-tissue integration process will be measured by inflammatory parameters (ININ, IL-17, and IL-1b expression), angiogenesis (CD-31 expression) and collagen deposition will be assessed using Masson’s Trichrome staining.

RESULTS

This study is at the protocol development stage. A preliminary study regarding its feasibility, including preparation of hypoestrogenic rabbit model, mesh implantation in the rabbit's vesicovaginal space, PRP and amnion scaffold, has started since February 2022. The results of this study are expected to be available by the end of 2022.

CONCLUSIONS

This randomized controlled trial is designed to provide high-quality evidence on the effect of platelet-rich plasma-decellurized amnion scaffold application to polypropylene mesh in vesicovaginal space of the hypoestrogenic rabbit model.
Social Listening to Enhance Access to Appropriate Pandemic Information Among Culturally Diverse Populations: Case Study From Finland (Preprint)
Authors: Lohiniva Anna-Leena , Sibenberg Katja , Austero Sara , Skogberg Natalia
Published: April 2022

BACKGROUND

Social listening, the process of monitoring and analyzing conversations to inform communication activities, is an essential component of infodemic management. It helps inform context-specific communication strategies that are culturally acceptable and appropriate for various subpopulations. Social listening is based on the notion that target audiences themselves can best define their own information needs and messages.

OBJECTIVE

This study aimed to describe the development of systematic social listening training for crisis communication and community outreach during the COVID-19 pandemic through a series of web-based workshops and to report the experiences of the workshop participants implementing the projects.

METHODS

A multidisciplinary team of experts developed a series of web-based training sessions for individuals responsible for community outreach or communication among linguistically diverse populations. The participants had no previous training in systematic data collection or monitoring. This training aimed to provide participants with sufficient knowledge and skills to develop a social listening system based on their specific needs and available resources. The workshop design took into consideration the pandemic context and focused on qualitative data collection. Information on the experiences of the participants in the training was gathered based on participant feedback and their assignments and through in-depth interviews with each team.

RESULTS

A series of 6 web-based workshops was conducted between May and September 2021. The workshops followed a systematic approach to social listening and included listening to web-based and offline sources; rapid qualitative analysis and synthesis; and developing communication recommendations, messages, and products. Follow-up meetings were organized between the workshops during which participants could share their achievements and challenges. Approximately 67% (4/6) of the participating teams established social listening systems by the end of the training. The teams tailored the knowledge provided during the training to their specific needs. As a result, the social systems developed by the teams had slightly different structures, target audiences, and aims. All resulting social listening systems followed the taught key principles of systematic social listening to collect and analyze data and used these new insights for further development of communication strategies.

CONCLUSIONS

This paper describes an infodemic management system and workflow based on qualitative inquiry and adapted to local priorities and resources. The implementation of these projects resulted in content development for targeted risk communication, addressing linguistically diverse populations. These systems can be adapted for future epidemics and pandemics.