bluuebunny/crossref_metadata_2025 huggingface dataset:
Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
Authors: Juarez Pablo , Martínez Cerdeño Verónica
Published: October 2022

Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ interneurons provide a quick and stable inhibitory input to pyramidal neurons and contribute to the generation of gamma oscillations in the cortex. Their fast-firing rates, while advantageous for regulating cortical signaling, also leave them vulnerable to metabolic stress. Chandelier (Ch) cells are a type of PV+ interneuron that modulate the output of pyramidal neurons and synchronize spikes within neuron populations by directly innervating the pyramidal axon initial segment. Changes in the morphology and/or function of PV+ interneurons, mostly of Ch cells, are linked to neurological disorders. In ASD, the number of PV+ Ch cells is decreased across several cortical areas. Changes in the morphology and/or function of PV+ interneurons have also been linked to schizophrenia, epilepsy, and bipolar disorder. Herein, we review the role of PV and PV+ Ch cell alterations in ASD and other psychiatric disorders.
Time trends in the burden of stroke and subtypes attributable to PM2.5 in China from 1990 to 2019
Authors: Chen Huijing , Zhou Zhihua , Li Zhenglong , Liang Shanshan , Zhou Jingjing , Zou Guanyang , Zhou Shangcheng
Published: October 2022

Background

Increasing studies have found that PM2.5 has large adverse effects on stroke mortality. We want to investigate the long-term trends in the mortality of stroke attributable to ambient particulate matter pollution and household air pollution to provide evidence facilitating the design of policy.

Methods

The deaths data of stroke and its subtypes attributable to PM2.5 were obtained from the Global Burden of Disease (GBD) 2019, analyzed by Joinpoint regression software and the age-period-cohort (APC) method to assess the magnitude of the trends in mortality and the temporal trends in the mortality rate by age, period, and cohort.

Results

From 1990 to 2019, the age-standardized mortality rate (ASMR) attributable to PM2.5 exposure trended downwards, but the trends of ambient particulate matter pollution and household air pollution were opposite. The trends varied among subtypes, the AAPC of intracerebral hemorrhage, ischemic stroke, and subarachnoid hemorrhage attributable to PM2.5 were 0.7, 2.5, and−3.3%, respectively. The longitudinal age curve of the APC model showed that the mortality rates due to PM2.5 exposure increased with age. The period RRs of ischemic stroke due to ambient particulate matter pollution increased significantly. The cohort RRs of ambient particulate matter pollution increased among those born from 1905 to 1990. The net drifts of all subtypes attributable to PM2.5 were below 0, but owing to the increase of ambient particulate matter pollution, the range of the decline was small. Males had higher net drift values, compared with females.

Conclusions

Ambient particulate matter pollution has become the main type of PM2.5 leading to stroke in China. PM2.5 exposure is more harmful to ischemic stroke, males, and elderly. Chinese government should pay attention to the long-term impact of ambient air pollution on stroke and take effective public health policies and interventions.
Probiotics beyond the farm: Benefits, costs, and considerations of using antibiotic alternatives in livestock
Authors: Leistikow Kyle R. , Beattie Rachelle E. , Hristova Krassimira R.
Published: October 2022

The increasing global expansion of antimicrobial resistant infections warrants the development of effective antibiotic alternative therapies, particularly for use in livestock production, an agricultural sector that is perceived to disproportionately contribute to the antimicrobial resistance (AMR) crisis by consuming nearly two-thirds of the global antibiotic supply. Probiotics and probiotic derived compounds are promising alternative therapies, and their successful use in disease prevention, treatment, and animal performance commands attention. However, insufficient or outdated probiotic screening techniques may unintentionally contribute to this crisis, and few longitudinal studies have been conducted to determine what role probiotics play in AMR dissemination in animal hosts and the surrounding environment. In this review, we briefly summarize the current literature regarding the efficacy, feasibility, and limitations of probiotics, including an evaluation of their impact on the animal microbiome and resistome and their potential to influence AMR in the environment. Probiotic application for livestock is often touted as an ideal alternative therapy that might reduce the need for antibiotic use in agriculture and the negative downstream impacts. However, as detailed in this review, limited research has been conducted linking probiotic usage with reductions in AMR in agricultural or natural environments. Additionally, we discuss the methods, including limitations, of current probiotic screening techniques across the globe, highlighting approaches aimed at reducing antibiotic usage and ensuring safe and effective probiotic mediated health outcomes. Based on this information, we propose economic and logistical considerations for bringing probiotic therapies to market including regulatory roadblocks, future innovations, and the significant gaps in knowledge requiring additional research to ensure probiotics are suitable long-term options for livestock producers as an antibiotic alternative therapy.
The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
Authors: Birkisdóttir María B. , van Galen Ivar , Brandt Renata M. C. , Barnhoorn Sander , van Vliet Nicole , van Dijk Claire , Nagarajah Bhawani , Imholz Sandra , van Oostrom Conny T. , Reiling Erwin , Gyenis Ákos , Mastroberardino Pier G. , Jaarsma Dick , van Steeg Harry , Hoeijmakers Jan H. J. , Dollé Martijn E. T. , Vermeij Wilbert P.
Published: October 2022

Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- and lifespan across species. However, effective genome-protecting compounds are largely lacking. Here, we use Ercc1Δ/− and Xpg−/− DNA repair-deficient mutants as two bona fide accelerated aging mouse models to test propitious anti-aging pharmaceutical interventions. Ercc1Δ/− and Xpg−/− mice show shortened lifespan with accelerated aging across numerous organs and tissues. Previously, we demonstrated that a well-established anti-aging intervention, dietary restriction, reduced DNA damage, and dramatically improved healthspan, strongly extended lifespan, and delayed all aging pathology investigated. Here, we further utilize the short lifespan and early onset of signs of neurological degeneration in Ercc1Δ/− and Xpg−/− mice to test compounds that influence nutrient sensing (metformin, acarbose, resveratrol), inflammation (aspirin, ibuprofen), mitochondrial processes (idebenone, sodium nitrate, dichloroacetate), glucose homeostasis (trehalose, GlcNAc) and nicotinamide adenine dinucleotide (NAD+) metabolism. While some of the compounds have shown anti-aging features in WT animals, most of them failed to significantly alter lifespan or features of neurodegeneration of our mice. The two NAD+ precursors; nicotinamide riboside (NR) and nicotinic acid (NA), did however induce benefits, consistent with the role of NAD+ in facilitating DNA damage repair. Together, our results illustrate the applicability of short-lived repair mutants for systematic screening of anti-aging interventions capable of reducing DNA damage accumulation.
Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
Authors: Müller Lisa , Andrée Marcel , Moskorz Wiebke , Drexler Ingo , Hauka Sandra , Ptok Johannes , Walotka Lara , Grothmann Ramona , Hillebrandt Jonas , Ritchie Anastasia , Peter Laura , Walker Andreas , Timm Jörg , Adams Ortwin , Schaal Heiner
Published: October 2022

We provide follow-up data on the humoral immune response after COVID-19 vaccinations of two distinct cohorts aged below 60 and over 80 years to screen for age-related differences in the longevity and magnitude of the induction of the antibody responses post booster-vaccinations. While anti-SARS-CoV-2 spike-specific IgG and neutralization capacity waned rapidly after the initial vaccination schedule, additional boosters highly benefitted the humoral immune responses especially in the elderly cohort, including the neutralization of Omikron variants. Thus, adjusted COVID-19 booster vaccination schedules are an appropriate tool to overcome limitations in the success of vaccinations.
The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons
Authors: Lodato Michael A. , Ziegenfuss Jennifer S.
Published: October 2022

Maintaining genomic integrity in post-mitotic neurons in the human brain is paramount because these cells must survive for an individual’s entire lifespan. Due to life-long synaptic plasticity and electrochemical transmission between cells, the brain engages in an exceptionally high level of mitochondrial metabolic activity. This activity results in the generation of reactive oxygen species with 8-oxo-7,8-dihydroguanine (8-oxoG) being one of the most prevalent oxidation products in the cell. 8-oxoG is important for the maintenance and transfer of genetic information into proper gene expression: a low basal level of 8-oxoG plays an important role in epigenetic modulation of neurodevelopment and synaptic plasticity, while a dysregulated increase in 8-oxoG damages the genome leading to somatic mutations and transcription errors. The slow yet persistent accumulation of DNA damage in the background of increasing cellular 8-oxoG is associated with normal aging as well as neurological disorders such as Alzheimer’s disease and Parkinson’s disease. This review explores the current understanding of how 8-oxoG plays a role in brain function and genomic instability, highlighting new methods being used to advance pathological hallmarks that differentiate normal healthy aging and neurodegenerative disease.
A Simple, interpretable method to identify surprising topic shifts in scientific fields
Authors: Cheng Lu , Foster Jacob G. , Lee Harlin
Published: October 2022

This paper proposes a text-mining framework to systematically identify vanishing or newly formed topics in highly interdisciplinary and diverse fields like cognitive science. We apply topic modeling via non-negative matrix factorization to cognitive science publications before and after 2012; this allows us to study how the field has changed since the revival of neural networks in the neighboring field of AI/ML. Our proposed method represents the two distinct sets of topics in an interpretable, common vector space, and uses an entropy-based measure to quantify topical shifts. Case studies on vanishing (e.g., connectionist/symbolic AI debate) and newly emerged (e.g., art and technology) topics are presented. Our framework can be applied to any field or any historical event considered to mark a major shift in thought. Such findings can help lead to more efficient and impactful scientific discoveries.
Instrumenting a virtual reality headset for at-home gamer experience monitoring and behavioural assessment
Authors: Moinnereau Marc-Antoine , Oliveira Alcyr A. , Falk Tiago H.
Published: October 2022

Measuring a gamer’s behaviour and perceived gaming experience in real-time can be crucial not only to assess game usability, but to also adjust the game play and content in real-time to maximize the experience per user. For this purpose, affective and physiological monitoring tools (e.g., wearables) have been used to monitor human influential factors (HIFs) related to quality of experience (QoE). Representative factors may include the gamer’s level of engagement, stress, as well as sense of presence and immersion, to name a few. However, one of the major challenges the community faces today is being able to accurately transfer the results obtained in controlled laboratory settings to uncontrolled everyday settings, such as the gamer’s home. In this paper, we describe an instrumented virtual reality (VR) headset, which directly embeds a number of dry ExG sensors (electroencephalography, EEG; electrocardiography, ECG; and electrooculography, EOG) to allow for gamer behaviour assessment in real-time. A protocol was developed to deliver kits (including the instrumented headset and controllers, laptop with the VR game Half-life Alyx, and a second laptop for data acquisition) to participants’ homes during the COVID-19 lockdown. A brief videoconference session was made to provide the participants with instructions, but otherwise the experiment proceeded with minimal experimenter intervention. Eight participants consented to participate and each played the game for roughly 1.5 h. After each gaming session, participants reported their overall experience with an online questionnaire covering aspects of emotions, engagement, immersion, sense of presence, motion sickness, flow, skill, technology adoption, judgement and usability. Here, we describe our obtained findings, as well as report correlations between the subjective ratings and several QoE-related HIFs measured directly from the instrumented headset. Promising results are reported.
DLITE—An inexpensive, deployable interferometer for solar radio burst observations
Authors: Carson George , Kooi Jason E. , Helmboldt Joseph F. , Markowski Blerta B. , Bonanno David J. , Hicks Brian C.
Published: October 2022

Solar radio bursts (SRBs) are brief periods of enhanced radio emission from the Sun. SRBs can provide unique insights into the plasma structure where emission occurs. SRBs can also provide critical information concerning space weather events such as coronal mass ejections or solar energetic particle events. Providing continuous monitoring of SRBs requires a full network of detectors continuously monitoring the Sun. A promising new network is being developed, employing a four-element interferometer called the Deployable Low-band Ionosphere and Transient Experiment (DLITE) array. DLITE, which operates in a 30–40 MHz band, was specifically designed to probe the Earth’s ionosphere using high resolution measurements (1.024-s temporal resolution, 16.276-kHz frequency resolution); however, this also makes DLITE a powerful new tool for providing detailed observations of SRBs at these frequencies. DLITE is particularly adept at detecting long-duration SRBs like Type II and Type IV bursts. DLITE provides high resolution SRB data that can complement ground-based networks like e-Callisto or space-based observations, e.g., from Wind/WAVES. As an inexpensive interferometer, DLITE has strong potential as an educational tool: DLITE can be used to study the ionosphere, SRBs, and even Jovian radio bursts. Future DLITE arrays could be enhanced by using the full 20–80 MHz band accessible by the antennas and employing its millisecond time-resolution capability; this would improve DLITE’s ability to track long-duration bursts, create the opportunity to study short-duration Type III bursts in detail, and, in particular, make the study of Type I bursts practical.
Characteristics and hotspots of the 50 most cited articles in the field of pre-psoas oblique lumbar interbody fusion
Authors: Lin Guang-Xun , Chen Chien-Min , Jhang Shang-Wun , Zhu Ming-Tao , Lyu Pengfei , Hu Bao-Shan
Published: October 2022

Purpose

In the past decade, the field of pre-psoas oblique lumbar interbody fusion (OLIF) has developed rapidly, and with it, the literature on OLIF has grown considerably. This study was designed to analyze the top 50 articles in terms of the number of citations through bibliometric research to demonstrate the research characteristics and hotspots of OLIF.

Method

Searching the Web of Science database yielded the 50 most cited publications in the OLIF field as of July 10, 2022. The publications were ranked according to the number of citations. The following sources were evaluated: the year of publications, the number of citations, authors, countries, institutions, journals, research topics, and keyword hotspots.

Results

The most productive period was from 2017 to 2020, with 41 articles. The number of citations varied from 10 to 140, with an average of 35.52, and 1,776 citations were found. World Neurosurgery published the most articles (12), China produced the most articles (16), and the Catholic University of Korea produced the most studies (6). The corresponding author who produced the most articles was J.S. Kim (5), and the first author who produced the most publications was S. Orita (3). The main research topics were anatomical morphology, surgical techniques, indications, outcomes, and complications. The top 10 most cited keywords were “complications,” “decompression,” “spine,” “surgery,” “outcomes,” “transpsoas approach,” “spondylolisthesis,” “anterior,” “disease,” and “injury.”

Conclusions

Certain articles can be distinguished from others using citation analysis as an accurate representation of their impact due to their long-term effectiveness and peer recognition. With these publications, researchers are provided with research priorities and hotspots through influential literature in the field of OLIF.
Geometrical model establishment and preoperative evaluation on A-T flap design: Finite element method-based computer-aided simulation on surgical operation processes
Authors: Zhao Yan , Yang Zonglin , Chen Lifen , Peng Yuhui
Published: October 2022

Objective

A-T flap has been extensively applied to repair dermal soft tissue defects. The flap design completely depends on the experience of doctors. Herein, we explored the approach of analyzing the reasonability of A-T flap design and performed a simulation of operation processes by computer-aided technology. Afterward, the finite element analysis software (MSC.Marc/Mentat) was used to establish the simulation model, based on which the computer simulation of flap suturing and release state in A-T flap surgery was performed.

Methods

A geometrical model of the A-T flap was established, and the length-width ratio of the flap, maximum suture distance, and suture area that could influence the postoperative suture effects of the flap were analyzed. The reasonable surgical planning for A-T flap design based on the crossing constraint relationship was achieved. The simulation model was established by the finite element analysis software (MSC.Marc/Mentat), based on which computer simulation of flap suture and release state of A-T flap in surgery processes were performed. The flap’s stress and deformation distribution results confirmed the applicability of the A-T flap design method proposed in the present study.

Results

When the apex angle of the A-T flap was 60 degrees, the suture area was the smallest, and the flap design had the highest practicability.

Conclusion

Computer-assisted preoperative assessment, which has high clinical value, could provide a theoretical basis for A-T flap design in clinical practice.
The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials
Authors: El Yamani N. , Rundén-Pran E. , Collins A. R. , Longhin E. M. , Elje E. , Hoet P. , Vinković Vrček I. , Doak S. H. , Fessard V. , Dusinska M.
Published: October 2022

Thein vitrocomet assay is a widely applied method for investigating genotoxicity of chemicals including engineered nanomaterials (NMs). A big challenge in hazard assessment of NMs is possible interference between the NMs and reagents or read-out of the test assay, leading to a risk of biased results. Here, we describe both the standard alkaline version of thein vitrocomet assay with 12 mini-gels per slide for detection of DNA strand breaks and the enzyme-modified version that allows detection of oxidized DNA bases by applying lesion-specific endonucleases (e.g., formamidopyrimidine DNA glycosylase or endonuclease III). We highlight critical points that need to be taken into consideration when assessing the genotoxicity of NMs, as well as basic methodological considerations, such as the importance of carrying out physicochemical characterization of the NMs and investigating uptake and cytotoxicity. Also, experimental design—including treatment conditions, cell number, cell culture, format and volume of medium on the plate—is crucial and can have an impact on the results, especially when testing NMs. Toxicity of NMs depends upon physicochemical properties that change depending on the environment. To facilitate testing of numerous NMs with distinct modifications, the higher throughput miniaturized version of the comet assay is essential.
Barriers to and facilitators of pet grooming among clients served by a subsidized grooming service program
Authors: McDonald Shelby E. , Doherty Colleen , Sweeney Jessica , Kisiel Lisa , Matijczak Angela , Niestat Laura , Gupta Maya
Published: October 2022

Grooming is an important aspect of basic hygiene care for most companion animals. The consequences of not receiving routine grooming care can pose significant risks to animals' health and wellbeing. The current study examined barriers and facilitators of maintaining pets' grooming needs among clients of a subsidized grooming service program in New York City (N= 167), as well as the impact of a tailored nail-trimming demonstration on clients' confidence trimming pets' nails. Ninety-two percent of the sample reported experiencing at least one barrier to maintaining their pet's grooming (e.g., income, transportation) and nearly half (46%) experienced three or more barriers to providing grooming. Ninety-one percent endorsed that at least one supply/support (e.g., brush/comb, behavioral support) would be beneficial in maintaining their pet's grooming needs at home and more than half reported that three or more supplies/services would be beneficial. Differences in the prevalence of specific barriers to grooming were found across income groups, service locations, and service settings. Clients who received nail-trimming demonstrations, on average, reported statistically significant increases in confidence trimming nails following their appointment. We discuss the implications of these findings for improving animal welfare and veterinary professionals' capacity for preventing grooming-related omissions of care and increasing communities' capacity to support pet owners' access to essential pet care supplies and supports. Future research is needed to determine (a) how and for whom grooming demonstrations and subsidized services are most effective, (b) whether an increase in pet owner confidence following nail trimming demonstrations is associated with maintaining nail trimming at home over time, and (c) whether providing clients with supplies and supports is an effective way of preventing and/or ameliorating future grooming-related omissions of care and hygiene-related health concerns observed by veterinarians, animal control professionals, shelter staff, and law enforcement.
The economic impact of porcine reproductive and respiratory syndrome outbreak in four Chinese farms: Based on cost and revenue analysis
Authors: Zhang Zhendong , Li Zhi , Li Hao , Yang Shuqing , Ren Fubo , Bian Ting , Sun Liumei , Zhou Bin , Zhou Lei , Qu Xiangyang
Published: October 2022

The economic impact after the outbreak of porcine reproductive and respiratory syndrome (PRRS) has been proven to be tremendous for pig production worldwide. However, the economic impact of the disease is not well understood in China. In our previous study, we acquired and analyzed the main production data (the number of weaned piglets, health costs, delayed marketing age, etc.) from the management system before and after the PRRS outbreaks occurring in November 2014, March 2015, December 2016, and February 2017. This study aimed to analyze and quantify the economic losses of the four PRRS outbreaks in Chinese herds. A straightforward approach was used to calculate additional costs and decreased revenues based on the PRRS-induced production deficiencies by average cost-of-production indices calculated from annual estimates of costs between 2014 and 2017. The results showed that economic losses varied between ¥668.14 and ¥1004.43 per sow in breeding herds from the outbreaks to regain the basic performance, with an average of ¥822.75 per sow, and the mean costs in the fattening herds (including nursery pigs) were ¥601.62 per sow, ranging from ¥318.64 to ¥937.14. Overall, the economic impact of PRRS on the whole herd was ¥1424.37 per sow. The majority of the losses were due to the reduction in the number of weaned piglets for breeding herds, and the increased feed cost (occupying 44.88%) was the primary source of loss for fattening herds. Our study fills the gap in knowledge of PRRS economics in China, enriches the data for veterinary economics, and re-stresses the necessity for producers and veterinarians to control PRRS effectively.
Sodium humate alters the intestinal microbiome, short-chain fatty acids, eggshell ultrastructure, and egg performance of old laying hens
Authors: Li Chenqinyao , Li Xue , Li Piwu , Wei Bin , Zhang Cong , Zhu Xiaoling , Zhang Jie
Published: October 2022

This study investigated the effect of sodium humate supplementation on changes in the intestinal microbiome, intestinal short-chain fatty acids production, and trace element absorption in older laying hens, with consequent effects on egg performance and shell quality. We used the same hens as their own control; a total of 720 laying hens aged 422 days were randomly divided into three replicates, with the CON group fed a commercial diet at 422–441 days of age and the HANa group fed a commercial diet supplemented with 0.05% sodium humate at 442–461 days of age. Compared with the CON group, in the HANa group, Bacteroidetes and Actinobacteria were significantly increased, whereas, Firmicutes was significantly decreased. Further, Veillonella, Enterococcus, Lactobacillus, and Turricibacter significantly decreased, and Peptoniphilus, Helcococcus, GW-34, Psychrobacter, Anaerococcus, Corynebacterium, Facklamia, Trichococcus, Gallicola, Clostridium, and Oscillospira were significantly increased. The results showed that sodium humate significantly altered the alpha and beta diversity and changed the structure of the intestinal microbiome. Acetic acid, isovaleric acid, and isobutyric acid, among short-chain fatty acids were significantly increased in the HANa group, whereas trace elements such as Mn, Zn, and Fe were significantly reduced. The eggshell strength and ultrastructure were significantly altered. In this study, sodium humate was found to alter the intestinal microbiome structure of aged hens, change the production of short-chain fatty acids, and promote the absorption of trace elements to keep aged hens from experiencing a decrease in egg production performance.
Road Traffic Noise, Obesity, and the Risk of Incident Type 2 Diabetes: A Cohort Study in UK Biobank
Authors: Zuo Lei , Chen Xia , Liu Mingliang , Chen Li , Xu Wenbin , Chen Haiyan , Dong Shan , Wei Yuan , Li Liangming , Peng Shuang , Hao Guang
Published: October 2022

Objectives: To assess the association of road traffic noise exposure with Type 2 Diabetes (T2D) risk, and to explore the potential moderation effect of obesity.

Methods: A total of 305,969 participants from the UK Biobank Cohort - an open access cohort of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010 - were included in the study. A Cox proportional hazard model was fitted to assess the association between road traffic noise exposure and T2D.

Results: A total of 19,303 participants were diagnosed with T2D during the 11.9-year median follow-up period. For every 10 dB increase in road traffic noise, there was a 4% increase in T2D risk (HR = 1.04, 95%CI: 1.01, 1.07). Besides, a significant positive interaction was observed between obesity and road traffic noise (P interaction <0.001) for the risk of T2D. The association of road traffic noise with T2D was stronger in overweight and obese participants (HR = 1.04, 95% CI: 1.01–1.08), but not significant among lean ones (HR = 0.96, 95% CI: 0.86–1.07).

Conclusion: Our study observed a longitudinal association of road traffic noise exposure with T2D risk, which was stronger among overweight and obese individuals than the lean ones.
Hopf Bifurcation Analysis of the Combustion Instability in a Liquid Rocket Engine
Authors: Liang Xuanye , Yang Lijun , Wang Gaofeng , Li Jingxuan
Published: October 2022

The bifurcation process of self-sustained combustion instability pressure perturbations in a liquid rocket combustor is investigated based on the Helmholtz equations and a pressure dependent flame describing function. The modal frequency and growth rates are numerically resolved by the commercial software COMSOL multiphysics. Validation of the numerical approach is firstly conducted on a Rijke tube combustor, and a supercritical bifurcation for the first longitudinal mode is observed. The bifurcation diagrams for the first transverse mode for different time delays and gain index of the flame describing function are analyzed. Only the supercritical bifurcation presents for this configuration. The trajectory of Hopf points and the bifurcation diagram feature period motions with increasing the time delay. The effect of flame length distributions on the bifurcation diagrams is analyzed by considering a non-uniform flame length distribution model. Results show that the distribution has a large impact on the bifurcation process, e.g., the first transverse mode is more unstable for the non-uniform distribution. Finally, a subcritical bifurcation is found when a more complicated flame describing function is considered; the bistable region presents and the condition for this is discussed.
Adaptive Control System Design and Experiment Study of Gas Flow Regulation System for Variable Flow Ducted Rockets
Authors: Zhang Zongyu , Zeng Qinghua , Zou Yijun , Wang Hongfu , Tang Meng
Published: October 2022

Variable flow ducted rockets (VFDRs) are promising candidates for propulsion systems in hypersonic vehicles because of their inherent advantages, such as high specific impulse, low weight, and high speed. The control of gas flow is essential for optimal VFDRs performance. However, the characteristics of gas flow regulation systems, such as anti-regulation, non-linearity, and parameter variation, make it difficult to construct gas flow controllers. Aiming at the above problems, we propose a compound control strategy integrating a novel second-order fuzzy adaptive tracking differentiator (SOA-TD) and an intelligent proportional-integral controller based on adaptive neuro-fuzzy inference system (ANFIS). First, a mathematical model of a gas flow regulation system was developed to analyze the control characteristics of VFDRs. Next, an ANFIS-based proportional-integral controller to developed to respond to the system’s time-varying characteristics. In addition, a novel SOA-TD was constructed to optimize the “arrange transient process” of instructions, which effectively suppressed anti-regulation of the gas flow without increasing response time. Finally, a hardware in loop (HIL) simulation device for VFDRs was established, and serial HIL simulation tests were carried out to verify the validation of the controller. The HIL simulation results indicate that our strategy exhibited a superior performance compared to traditional controllers in terms of adaptability, ability to suppress anti-regulation, and robustness, which is hoped to fulfill VFDRs’ thrust control requirements for a wide range of altitudes and Mach numbers in future engineering applications.
Sustainable Tillage and Sowing Technologies
Authors: Romaneckas Kęstutis
Published: October 2022

Environmentally friendly and energy-efficient farming technologies are integrated into agricultural production as cutting-edge technologies that provide the greatest economic, energy and environmental benefits [...]
Factors Affecting Postharvest Losses of Sesame (Sesamum indicum L.) and Their Mitigation Strategies
Authors: Usman Muhammad , Razzaq Maryam , Khan Rana Ahsan Rehman , Rehman Muhammad Abdur , Ali Muhammad Moaaz , Gull Shaista , Yousef Ahmed Fathy , Adnan Muhammad , Ercisli Sezai , Golokhvast Kirill S.
Published: October 2022

Current postharvest activities in the sesame value chain are prompting colossal losses, which reduce overall global productivity. This review portrays losses in sesame during various processing stages, from grain harvesting to marketing and transformation of crop seed into oil. Such losses in sesame not only reduce yield but also have an impact on the economy of its production territories. The loss in productivity is because the majority of farmers don’t use adequate harvesting, packaging, or handling technologies to manage on-farm produce. Also, there is a lack of knack for minimizing postharvest losses. Therefore, the study penlights the inevitability of increasing production by raising productivity and quality while giving mitigation strategies to reduce postharvest losses. Elevating standardized productivity with accurate postharvest management is the only substitute for the gap between the global productivity average and the overall production potential of sesame.
Nitrogen Fertilization and Glyphosate as a Growth Regulator: Effects on the Nutritional Efficiency and Nutrient Balance in Emerald Grass
Authors: Dinalli Raíssa Pereira , Buzetti Salatiér , Gazola Rodolfo de Niro , de Castilho Regina Maria Monteiro , Jalal Arshad , Galindo Fernando Shintate , Teixeira Filho Marcelo Carvalho Minhoto
Published: October 2022

Nitrogen (N) is one of the promising nutrients for lawn growth and is required for the lawn’s proper growth and development, but it also increases mowing frequency. Glyphosate herbicide application in sub-doses, as a growth regulator, can reduce the maintenance costs without any adverse reduction in the density and nutritional status of grasses. The objective of this study was to evaluate the influences of nitrogen and glyphosate doses on the growth, aesthetic quality and nutritional status of emerald grass (Zoysia japonica Steud.). The experiment was conducted at the Research and Extension Education Farm of São Paulo State University (UNESP), Ilha Solteira, SP, Brazil, in an Ultisol. The experiment was designed as a randomized block with 12 treatments arranged in a 3 × 4 factorial scheme with 4 replications, comprised of a control (without N), 15 and 30 g N m−2 of urea, applied in five splits annually, and glyphosate doses (0, 200, 400 and 600 g ha−1 of the active ingredient, a.i.). The split N fertilization at the rate of 15 g m−2 and glyphosate at the dose of 400 g ha−1 maintained nutritional status of emerald grass. Nitrogen at the rate 15 g N m−2 (in five splits per year) was observed to produce lower growth traits, an adequate aesthetic quality and longer stability of the nutrients in emerald grasses through lower exportation, with removal of “clipping” after mowing. In addition, glyphosate, at the dose of 400 g a.i. ha−1, was efficient in reducing the leaf area, plant height, shoot dry matter and total dry matter by 18.3, 14.7, 6.8 and 8.1%, respectively, as compared to the control. However, this dose did not impair the coloration and resulted in a lower exportation of nutrients by reducing the need to replenish by fertilization. Therefore, fertilization with 15 g N m−2, associated with application of 400 g a.i. ha−1 of glyphosate, is recommended for emerald grass in the tropical savannah of Brazil.
Bayesian Non-Parametric Thermal Thresholds for Helicoverpa armigera and Their Integration into a Digital Plant Protection System
Authors: Damos Petros , Papathanasiou Fokion , Tsikos Evaggelos , Kyriakidis Thomas , Louta Malamati
Published: October 2022

The development of temperature-driven pest risk thresholds is a prerequisite for the buildup and implementation of smart plant protection solutions. However, the challenge is to convert short and abrupt phenology data with limited distributional information into ecological relevant information. In this work, we present a novel approach to analyze phenology data based on non-parametric Bayesian methods and develop degree-day (DD) risk thresholds for Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) to be used in a decision support system for dry bean (Phaseolus vulgaris L.) production. The replication of each Bayesian bootstrap generates a posterior probability for each sampling set by considering that the prior unknown distribution of pest phenology is Dirichlet distribution. We computed R = 10,000 temperature-driven pest phenology replicates, to estimate the 2.5%, 50% and 95.5% percentiles (PC) of each flight generation peak in terms of heat summations. The related DD thresholds were: 114.04 (PC 2.5%) 131.8 (PC 50%) and 150.9 (PC 95.5%) for the first, 525.8 (PC 2.5%), 551.7 (PC 50%) and 577.6 (PC 95.5%) for the second and 992.7 (PC 2.5%), 1021.5 (PC 50%) and 1050 (PC 95.5%) for the third flight, respectively. The thresholds were evaluated by estimating the posterior differences between the predicted (2021) and observed (2022) phenology metrics and are in most cases in acceptable levels. The bootstrapped Bayesian risk thresholds have the advantage to be used in modeling short and noisy data sets providing tailored pest forecast without any parametric assumptions. In a second step the above thresholds were integrated to a sub-module of a digital weather-driven real time decision support system for precise pest management for dry bean crops. The system consists of a customized cloud based telemetric meteorological network, established over the border area of the Prespa National Park in Northern Greece, and delivers real time data and pest specific forecast to the end user.
Control of Problematic Weeds in Mediterranean Vineyards with the Bioherbicide Pelargonic Acid
Authors: Muñoz Marta , Torres-Pagán Natalia , Jouini Amira , Araniti Fabrizio , Sánchez-Moreiras Adela M. , Verdeguer Mercedes
Published: October 2022

Pelargonic acid (PA) is the only natural herbicide authorized for professional use in Spain. Incorporating PA into an integrated weed management strategy in vineyards may enable a more sustainable production method for grapes. In this work, PA of 55% concentration, formulated by a commercial company (PSEI), was evaluated and applied at 8, 10, 12, and 15 L/ha for weed control in Mediterranean vineyards during 2020 and 2021. A total of 22 different weed species, 16 dicotyledonous and 6 monocotyledonous, were identified in the experimental areas. Previously, greenhouse assays were performed against Avena fatua L. and Chenopodium album L. to determine the dose/response curves. PSEI proved to be a viable post-emergence herbicide with an efficacy of 40.79–80.90%, depending on the applied dose (higher doses were the most effective). Broader herbicidal activity (20% or more) was obtained against dicotyledonous weeds compared with monocotyledonous. The PA formulation was remarkable in achieving PSEI-similar effects as compared to the market reference but at lower concentrations (around 13% less PA) and doses (1–8 less L/ha). PA has proved to be a good candidate to control weeds in Mediterranean vineyards when used as a post-emergence broad-spectrum herbicide in the first stages of weed development.
Effects of Fermented Bamboo Shoot Processing Waste on Growth Performance, Serum Parameters, and Gut Microbiota of Weaned Piglets
Authors: Huang Yuanhao , Peng Yingjie , Yang Zheng , Chen Siyu , Liu Jing , Wang Zheng , Wang Gang , Lan Shile
Published: October 2022

Gut microbiota (GM) plays a vital role in the nutrition and metabolism of weaned piglets. Some feed additives can be used to adjust the composition of GM to improve the health of weaned piglets. In this study, we investigated the effects of adding fermented bamboo shoot processing waste (FBSPW) to diet on growth performance, serum parameters, and GM of weaned piglets. Seventy-two piglets were divided into four groups and were fed diets containing 0% (control), 4% (group A), 8% (group B), and 12% (group C) FBSPW for 50 days. We found that the addition of FBSPW significantly decreased the average daily feed intake, serum triglyceride content, and urea nitrogen of weaned piglets compared to the control. The cecum and cecal microbiota of weaned piglets fed the basal diet with 12% FBSPW were significantly different compared to the control. A basal diet with 12% FBSPW significantly reduced the taxon feature number, and the relative abundance of Tenericutes in the cecum and cecal microbiota of weaned piglets compared with the control. The addition of 12% FBSPW to weaned piglet feed could improve their nitrogen and lipid metabolisms and have beneficial effects on GM.
Exogenously-Sourced Salicylic Acid Imparts Resilience towards Arsenic Stress by Modulating Photosynthesis, Antioxidant Potential and Arsenic Sequestration in Brassica napus Plants
Authors: Bano Koser , Kumar Bharty , Alyemeni Mohammed Nasser , Ahmad Parvaiz
Published: October 2022

In the current study, salicylic acid (SA) assesses the physiological and biochemical responses in overcoming the potential deleterious impacts of arsenic (As) on Brassica napus cultivar Neelam. The toxicity caused by As significantly reduced the observed growth and photosynthetic attributes and accelerated the reactive oxygen species (ROS). Plants subjected to As stress revealed a significant (p ≤ 0.05) reduction in the plant growth and photosynthetic parameters, which accounts for decreased carbon (C) and sulfur (S) assimilation. Foliar spray of SA lowered the oxidative burden in terms of hydrogen peroxide (H2O2), superoxide anion (O2•−), and lipid peroxidation in As-affected plants. Application of SA in two levels (250 and 500 mM) protected the Brassica napus cultivar from As stress by enhancing the antioxidant capacity of the plant by lowering oxidative stress. Among the two doses, 500 mM SA was most effective in mitigating the adverse effects of As on the Brassica napus cultivar. It was found that SA application to the Brassica napus cultivar alleviated the stress by lowering the accumulation of As in roots and leaves due to the participation of metal chelators like phytochelatins, enhancing the S-assimilatory pathway, carbohydrate metabolism, higher cell viability in roots, activity of ribulose 1, 5-bisphosphate carboxylase (Rubisco), and proline metabolism through the active participation of γ-glutamyl kinase (GK) and proline oxidase (PROX) enzyme. The current study shows that SA has the capability to enhance the growth and productivity of B. napus plants cultivated in agricultural soil polluted with As and perhaps other heavy metals.
Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis
Authors: Qin Tao , Feng Danni , Zhou Bangyue , Bai Lirong , Yin Yinyan
Published: October 2022

Melatonin, an indoleamine synthesized in the pineal gland of mammals, is a natural bioactive compound with powerful antioxidant and anti-inflammatory properties. Here, we evaluated whether melatonin has the capacity to moderate the oxidative stress of dendritic cells (DCs) for inflammatory control in an acute lung injury (ALI) model. Our findings showed that melatonin remarkably inhibited total nitric oxide synthase (T-NOS) activity, nitric oxide (NO) production, intracellular reactive oxygen species (ROS) levels, and lipid peroxidation (MDA detection) levels in both an LPS-induced murine ALI model and LPS-induced DCs. Meanwhile, the reduced glutathione (GSH) level and the GSH/GSSG ratio were recovered. In addition, antioxidant enzymes, such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), were increased in these processes. Moreover, melatonin also inhibited the LPS-induced secretions of IL-1β, IL-6, and TGF-β in vivo and in vitro. Finally, we found that the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) axis was required in the inhibition of LPS-induced oxidative stress in DCs by melatonin. Altogether, these data indicate that melatonin strongly suppresses the LPS-induced oxidative stress in DCs, which is a promising DC-targeted strategy via inflammatory control for ALI treatment.
Construction of Eigenfunctions to One Nonlocal Second-Order Differential Operator with Double Involution
Authors: Turmetov Batirkhan , Karachik Valery
Published: October 2022

In this paper, we study the eigenfunctions to one nonlocal second-order differential operator with double involution. We give an explicit form of the eigenfunctions to the boundary value problem in the unit ball with Dirichlet conditions on the boundary. For the problem under consideration, the completeness of the system of eigenfunctions is established.
Application of Orthogonal Polynomial in Orthogonal Projection of Algebraic Surface
Authors: Wang Xudong , Li Xiaowu , Lyu Yuxia
Published: October 2022

Point orthogonal projection onto an algebraic surface is a very important topic in computer-aided geometric design and other fields. However, implementing this method is currently extremely challenging and difficult because it is difficult to achieve to desired degree of robustness. Therefore, we construct an orthogonal polynomial, which is the ninth formula, after the inner product of the eighth formula itself. Additionally, we use the Newton iterative method for the iteration. In order to ensure maximum convergence, two techniques are used before the Newton iteration: (1) Newton’s gradient descent method, which is used to make the initial iteration point fall on the algebraic surface, and (2) computation of the foot-point and moving the iterative point to the close position of the orthogonal projection point of the algebraic surface. Theoretical analysis and experimental results show that the proposed algorithm can accurately, efficiently, and robustly converge to the orthogonal projection point for test points in different spatial positions.
SiO2-Alginate-Based Gel Polymer Electrolytes for Zinc-Ion Batteries
Authors: Tian Peishu , Zhong Xin , Gu Caiting , Wang Zhe , Shi Fengwei
Published: October 2022

Aqueous Zn-ion batteries (AZIBs) are quite promising energy sources. However, aqueous electrolytes present many challenges such as hydrolysis reactions, liquid leakage, Zn dendrites, and interfacial side reactions. To solve the above problems of aqueous electrolytes, in this study, a kind of SiO2-sodium alginate gel polymer electrolyte (SiO2-SA GPE) is prepared through a one-pot method. The SiO2-SA GPE possessed high ionic conductivity of 1.144 × 10−2 S·cm−1 and perfect mechanical strength. The Zn//LiFePO4 batteries assembled with SiO2-SA GPE delivered a high discharge specific capacity of 89.9 mAh g−1 (capacity retention = 74.9%) after 300 cycles at 1 C, which was much better than traditional liquid electrolytes (residual discharge capacity = 79.2 mAh g−1). Results of the rate performance and long cycle life of AZIBs proved that SiO2-SA GPE could effectively prevent zinc dendrites and side reactions, providing a feasible strategy for improving the performance of AZIBs.