bluuebunny/crossref_metadata_2025 huggingface dataset:
Intrusion Detection on Apache Spark Platform in Big data and Machine Learning Techniques
Authors:   Department of Computer Science and Engineering, PSN College of Engineering and Technology, Melathediyoor, Tirunelveli., Yamuna Bee Mrs.J. , Naveena E. ,   Department of Computer Science and Engineering, PSN College of Engineering and Technology, Melathediyoor, Tirunelveli., Elizabeth Thomas Reshma ,   Department of Computer Science and Engineering, PSN College of Engineering and Technology, Melathediyoor, Tirunelveli., Chandran Arathi ,   Department of Computer Science and Engineering, PSN College of Engineering and Technology, Melathediyoor, Tirunelveli., Raja M Siva Subramania ,   Department of Computer Science and Engineering, PSN College of Engineering and Technology, Melathediyoor, Tirunelveli., Akhilesh A. ,   Department of Computer Science and Engineering, PSN College of Engineering and Technology, Melathediyoor, Tirunelveli.
Published: June 2021

With the rising cyber-physical power systems and emerging danger of cyber-attacks, the traditional power services are faced with higher risks of being compromised, as vulnerabilities in cyber communications can be broken to cause material damage. Therefore, adjustment needs to be made in the present control scheme plan methods to moderate the impact of possible attacks on service quality. This paper, focuses on the service of synchronized source-load contribution in main frequency regulation, a weakness study is performed with model the attack intrusion process, and the risk review of the service is made by further model the attack impacts on the service’s bodily things. On that basis, the customary synchronized reserve allotment optimization model is adapted and the allocation scheme is correct according to the cyber-attack impact. The proposed alteration methods are validating through a case study, showing efficiency in defensive alongside the cyber-attack impacts.
Isolation and Identification of Indole Acetic Acid (IAA) Producing Bacteria from Organic Soil: Investigating Its Efficacy on Plant Growth
Authors:   Department of Microbiology, Sri Ramakrishna College of Arts and Science for Women, Coimbatore, Tamil Nadu-641044, India., P Yamini , Gopalakrishnan Reshmi ,   Department of Microbiology, Sri Ramakrishna College of Arts and Science for Women, Coimbatore, Tamil Nadu-641044, India., Prasad S Sanjay ,   Department of Microbiology, Department of Microbiology, CMS College of Science and Commerce, Coimbatore-641049, Tamil Nadu, India., R Karkuvelraja ,   Microbial Biodiversity and Bioenergy Lab, Department of Microbiology, Bharathidasan University, Tiruchirapalli-620024, India.
Published: June 2021

Indole acetic acid (IAA) production is a major property of rhizosphere bacteria that stimulates and facilitates plant growth. The present work deals with the isolation, characterization, and identification of indole acetic acid-producing bacteria from the rhizospheric soil. Out of four organisms isolated from serial dilution, Sample-2 confirmed thick bands of IAA production by TLC analysis. 16s rRNA analysis showed the isolated organism was found to be Pseudomonas fluorescence with a similarity of 88%. The isolated organism treat plants showed increased shoot and root length in plant growth analysis. In conclusion, the isolated IAA-producing bacteria can be used as efficient biofertilizer inoculants to promote plant growth.
Design of UWB Antenna for Human Body Communication
Authors:   Department of Electronics and Communications, B.N.M. Institute of Technology, Bangalore, India., Sheshaprasad N. , Rao Aditi ,   Department of Electronics and Communications, B.N.M. Institute of Technology, Bangalore, India., R Bhoomika ,   Department of Electronics and Communications, B.N.M. Institute of Technology, Bangalore, India., Saglani Eva D. ,   Department of Electronics and Communications, B.N.M. Institute of Technology, Bangalore, India.
Published: June 2021

A diamond-shaped patch antenna with slots for desirable return loss, gain, and bandwidth was designed to achieve the intended goal. ROGERS 5880 was chosen as the substrate material and the antenna was simulated using CST (Computer simulation Technology) software. The designed microstrip patch antenna has a bandwidth from 2.12 to 9.24 GHz. The proposed antenna was put on the human body and had a SAR value of 1.44 W/kg, which was determined to be within the acceptable limit of 1.6 W/kg. Hence, the antenna can be used for on-body communication which is not detrimental to the human body.
Índice de heterogeneidad cervical o longitud cervical en la predicción de parto pretérmino inminente en pacientes sintomáticas
Authors:   Hospital Central “Dr. Urquinaona”. Maracaibo. Venezuela, Reyna-Villasmil Eduardo , Mejia-Montilla Jorly , Reyna-Villasmil Nadia , Torres-Cepeda Duly , Rondón-Tapia Martha , Briceño-Pérez Carlos
Published: June 2021

Objetivo: Comparar el índice de heterogeneidad cervical con la longitud cervical en la predicción de parto pretérmino inminente en pacientes sintomáticas. Métodos. Estudio prospectivo realizado en mujeres con embarazos simples entre 24 y 35 semanas, con diagnóstico clínico de amenaza de parto pretérmino que asistieron al Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela. Al momento del diagnóstico las pacientes fueron evaluadas utilizando ecografía transvaginal para establecer los valores del índice de heterogeneidad cervical y longitud cervical. La resultante principal fue parto inminente (en los 7 días siguientes a la evaluación). Resultados. Fueron incluidas 326 pacientes, 152 mujeres presentaron parto pretérmino inminente (grupo A) y 251 pacientes fueron consideradas como controles (grupo B). No se encontraron diferencias entre los grupos con relación edad materna, nuliparidad, antecedente de parto pretérmino, antecedente de hábito tabáquico e índice de masa corporal (p = ns). Las pacientes del grupo A presentaron valores significativamente más bajos del índice de heterogeneidad cervical y longitud cervical comparado con las pacientes del grupo B (p < 0,0001). El índice de heterogeneidad cervical mostró un valor de área bajo la curva de 0,858 mientras que el valor del área bajo la curva de la longitud cervical fue de 0,985. La diferencia de la capacidad de discriminación entre las áreas bajo la curva de cada prueba fue significativa (p < 0,0001). Conclusión: El índice de heterogeneidad cervical no es superior a la longitud cervical en la predicción de parto pretérmino inminente en pacientes sintomáticas. Palabras clave: Índice de heterogeneidad cervical, Longitud cervical, Parto pretérmino, Predicción.
Sutura hemostática uterina en asociación con taponamiento intrauterino con balón SOS Bakri (“sandwich uterino”) para hemorragia posparto: reporte de un caso
Authors:   Hospital Luis Ortega Porlamar, Nueva Esparta, Venezuela, Saldari María , Veroes Jesús Alejandro , Martínez María , Yelamo Vanessa , Colmenares Marielys
Published: June 2021

La hemorragia posparto es la principal causa de morbimortalidad materna en todo el mundo. La rapidez con la que se presenta, en conjunto con la imprecisión clínica para estimar la pérdida sanguínea requiere una atención expedita. Se presenta el caso de una paciente que consultó en el Hospital Luis Ortega de Porlamar, Venezuela, por sangrado uterino persistente, secundario a atonía uterina, resistente a la administración de oxitócicos. Se efectuó sutura hemostática B-Lynch, sin lograr hemostasia, por lo que subsecuentemente se procede a realizar taponamiento uterino con balón SOS Bakri, obteniendo resultados satisfactorios. Los hallazgos se comparan con los datos globales reportados en otras publicaciones. Palabras clave: Hemorragia posparto, Atonía uterina, Sutura hemostática, Taponamiento uterino, Sándwich uterino.
AS IMPLICAÇÕES DA VISÃO DE MUNDO NA FORMAÇÃO DO LEITOR LITERÁRIO
Authors: Silva Alisson Jefferson Valentim da , Monteiro Davidson
Published: June 2021

Este artigo apresenta as implicações que as visões de mundo inerentes aos textos literários ensejam sobre a formação do leitor no espaço escolar. Para tanto, o referencial teórico abordou desde o próprio conceito de cosmovisão até os postulados da Teoria Literária acerca desta faceta da literatura. Tendo em vista as recomendações das OCNEM (2006) para a inscrição da literatura em sala de aula, elaboramos apontamentos tanto para o seu ensino quanto para a sua leitura, de modo que ambos os procedimentos levem em conta este aspecto do texto artístico para a formação de leitores literários. A pertinência do conceito de cosmovisão para os estudos literários e a formação do leitor surge da premissa de que no texto literário estão impressos componentes históricos ou culturais que articulam a visão de mundo, quer do autor, quer do “eu” que se exprime através do texto; e que, por esta razão, o leitor deve ajustar sua perspectiva de leitura sob a pena de não obter o máximo da leitura que faz.
DIREITOS DE CIDADANIA NO BRASIL: A EDUCAÇÃO EM QUESTÃO
Authors: Silva George Augusto da , Kunz Sidelmar Alves Da Silva , Queiroz Norma Lúcia Neris de
Published: June 2021

O objetivo deste artigo foi discutir os direitos de cidadania no Brasil, com ênfase no direito à educação. Abordou-se os antecedentes históricos das lutas pelas conquistas dos direitos sociais, em sentido amplo, e, de modo específico, a realidade do Brasil republicano. Refletiu-se, também, acerca da qualidade da educação como direito social. Metodologicamente, procedeu-se a exploração bibliográfica e documental de conceitos relevantes para o debate relativo ao fortalecimento dos processos democráticos. A pesquisa apontou que a cidadania, no Brasil, é, ainda, uma meta almejada por toda a sociedade. A educação deve ocupar lugar privilegiado de interesse nacional, pois se apresenta como direito fundamental para o fomento de outros direitos sociais. A escola, todavia, é uma das instituições da sociedade, que mais sofre repercussões dos processos que se eclodem no contexto social. O modelo político-econômico, as abruptas transformações de valores, hábitos, costumes, tradições, enfim, todo esse corolário se imiscui na organização e na arquitetação dos sistemas de ensino.
PROGRAMA MAIS EDUCAÇÃO: O QUE DIZEM PUBLICAÇÕES, LEGISLAÇÕES E PROFISSIONAIS DA EDUCAÇÃO?
Authors: Bittencourt Zoraia Aguiar , Morosini Marília Costa
Published: June 2021

Este artigo discute os contextos e os atores (inter)nacionais que fizeram emergir o Programa Mais Educação (PME) como uma ação do governo federal de indução à Educação Integral nas escolas brasileiras. Como aporte metodológico, a Abordagem do Ciclo de Políticas contribuiu para que fossem observados simultaneamente os contextos macro e micropolíticos. Sendo assim, o Contexto de Influência foi analisado a partir da realização de três pesquisas de Estado de Conhecimento, totalizando 96 artigos, teses e dissertações, o Contexto de Produção do Texto resultou de análise documental de cinco legislações brasileiras e o Contexto da Prática ficou conhecido a partir da realização de 15 entrevistas com profissionais envolvidos na política. Os resultados da pesquisa apontam que o PME resultou de encontros internacionais que exigem melhores índices nacionais da educação e que foi colocado em circulação a partir da municipalização da educação e da responsabilização dos professores.
POVOS INDÍGENAS NO LIVRO DIDÁTICO: “HISTÓRIA DE PERNAMBUCO”
Authors: Da Silva Maria Da Penha
Published: June 2021

Após a Lei n.º 11.645/2008, que tornou obrigatório o ensino da História e culturas dos povos indígenas na Educação Básica, nota-se que a temática indígena tem ocupado um volume maior de páginas nos livros didáticos de História. Ao mesmo tempo, vem atraindo a atenção de pesquisadores e pesquisadoras sobre esse objeto, assim, contribuindo para a ampliação dos debates acerca do uso de imagens, narrativas e representações dos povos indígenas nas escolas. É nesse contexto de debates que se insere o presente texto, em que propomos discutir alguns aspectos relacionados com a perspectiva ideológica que permeia as narrativas e as imagens dos povos indígenas no livro didático de História: Pernambuco, destinado ao uso por crianças, professores e professoras dos 4.º e 5.º anos do Ensino Fundamental. Nesse sentido, o referido livro traz em si as implicações pedagógicas de se conceber os povos indígenas pela ótica da teoria da mestiçagem.
Aplicação da logística reversa: estudo comparativo em empresas de diferentes segmentos de um município do estado do Paraná
Authors: Chiusoli Cláudio Luiz , Poczynek Josiane , Stefano Silvio Roberto
Published: June 2021

O estudo tem como objetivo analisar como é a aplicação da logística reversa de três empresas de diferentes ramos de atuação, levando em consideração as principais dificuldades e o destino dado aos materiais reciclados. Para tanto, foi adotada uma pesquisa classificada como exploratória, de caráter qualitativo, e aplicado um roteiro composto por perguntas abertas, caracterizando um estudo de caso. Por meio da pesquisa, foi possível identificar que as dificuldades que as organizações se deparam são especialmente devido à falta de incentivos municipais, conscientização e sensibilização da comunidade em geral. Dentre os principais achados, verificou-se a importância da reciclagem por meio da logística reversa, uma vez que destinam seus materiais para a produção de uma gama variada de itens, como telhas ecológicas, conduítes corrugados, cordas, vergalhões de aço, madeira plástica, embalagens para óleo lubrificante, dutos corrugados, luvas para emenda, além de substituir produtos como a pedra brita na construção civil.
Tổng quan các hoạt động dược lâm sàng tại nhà thuốc cộng đồng của một số quốc gia trên thế giới
Authors: Ngân Trần Thị , Phương Nguyễn Thị Thu , Mai Ngô Thị Quỳnh
Published: June 2021

Dược lâm sàng (Clinical Pharmacy) ra đời mở ra một hướng đi mới cho ngành Dược, đưa người dược sĩ đến gần hơn với quá trình chăm sóc sức khỏe người bệnh. Hoạt động ban đầu chủ yếu được thực hiện tại bệnh viện và sau đó, mở rộng ra các nhà thuốc cộng đồng. Hoạt động dược lâm sàng tại nhà thuốc cộng đồng còn là một khái niệm mới lạ tại một số quốc gia đang phát triển. Tại Việt Nam, các hoạt động dược lâm sàng bệnh viện đã được thúc đẩy phát triển bằng các văn bản hướng dẫn của Nhà nước, tuy nhiên các hoạt động tại nhà thuốc cộng đồng vẫn còn là một khái niệm mới, chưa được quan tâm thích đáng. Vì vậy để góp phần thúc đẩy sự phát triển các hoạt động dược lâm sàng tại nhà thuốc và nâng cao chất lượng chăm sóc sức khỏe cộng đồng, tổng quan này được tiến hành với mục tiêu mô tả các loại hình dịch vụ dược lâm sàng tại nhà thuốc cộng đồng của một số quốc gia trên thế giới bằng phương pháp tổng quan tài liệu từ hệ thống dữ liệu Medline/PubMed.
Thực trạng sử dụng kháng sinh cephalosporin trong điều trị nội trú tại Bệnh viện đa khoa Thuỷ Nguyên, Hải Phòng, năm 2019
Authors: Trường Phạm Văn , Diệp Đỗ Thị Bích , Phương Nguyễn Thị Thu , Phong Trương Đình
Published: June 2021

Nghiên cứu đã tiến hành hồi cứu trên 390 bệnh án nội trú của bệnh nhân trong giai đoạn từ ngày 01/01/2019 đến ngày 30/6/2019 tại Bệnh viện đa khoa huyện Thuỷ Nguyên, Hải Phòng nhằm mô tả thực trạng sử dụng kháng sinh nhóm cephalosporin trong điều trị nội trú. Kết quả: Kháng sinh Cephalosporin thế hệ 3 có mức độ tiêu thụ lớn nhất viện: 15,6 DDD/100 giường/ngày (93,5%). Phác đồ kháng sinh đơn độc chiếm ưu thế  với tỷ lệ 66,41%, đặc biệt phác đồ ceftizoxime được chỉ định nhiều nhất (36,4%). Thời gian sử dụng kháng sinh trung bình của bệnh nhân điều trị nội trú trong nghiên cứu là 7,4 ngày. Tỷ lệ phối hợp kháng sinh là 26,9% (105/131). Bệnh viện cần nâng cao công tác quản lý, giám sát sử dụng kháng sinh nhằm hạn chế sử dụng kháng sinh cephalosporin phổ rộng.
Một số yếu tố liên quan đến chất lượng giấc ngủ của sinh viên y đa khoa trường Đại học Y Dược Hải Phòng năm 2020
Authors: Thuận Hoàng Thị , Thanh Nguyễn Thị Phương , Ngọc Nguyễn Thị Minh , Linh Nguyễn Thị Thùy
Published: June 2021

Nghiên cứu mô tả cắt ngang trên 407 sinh viên y đa khoa của trường đại học Y Dược Hải Phòng năm 2020 nhằm mô tả một số yếu tố liên quan đến chất lượng giấc ngủ kém. Kết quả nghiên cứu cho thấy chất lượng giấc ngủ kém có liên quan với: Ảnh hưởng của học tập (học tập căng thẳng hoặc rất căng thẳng (OR = 1,98; 95% CI :1,28 - 2,08), đi trực nhiều hơn 4 buổi/tháng (OR = 2,4; 95% CI: 1,46 - 3,96)), thời gian ngủ (ngủ không đủ giấc (OR = 11,11; 95% CI :5,57 - 22,18); ngủ muộn từ 0h (OR = 3,98; 95% CI :2,46 - 6,16)), thói quen sinh hoạt như dùng chất kích thích (OR = 2,67; 95% CI :1,74 - 4,12). Từ kết quả trên, nhà trường cần tăng cường truyền thông về lợi ích việc ngủ sớm dậy sớm, tác hại của việc dùng chất kích thích, bên cạnh đó tổ chức các hoạt động ngoại khóa để sinh viên có cơ hội tham gia, giao lưu, giảm căng thẳng sau giờ học.
EKONOMİK FAKTÖRLER VE ULUSAL SAĞLIK SİSTEMLERİNDE TEKNİK ETKİNLİK: PANEL VERİYE DAYALI BİR UYGULAMA
Authors: KONCA Murat , TOP Mehmet
Published: June 2021

Amaç: Bu çalışmada OECD ülkelerinin sağlık sistemlerinin teknik etkinliğinin ve buna etki eden ekonomik faktörlerin incelenmesi amaçlanmıştır.Yöntem: Bu çalışmada, OECD ülkelerinin ulusal sağlık sistemlerinin teknik etkinliğini ortaya koymak adına girdi yönelimli ölçeğe göre değişken getirili Veri Zarflama Analizi (VZA) kullanılmıştır. VZA sonrasında panel Tobit regresyon ile çeşitli ekonomik faktörlerin (satın alma gücü paritesine göre kişi başına düşen $ (GDP), Gini Katsayısı (Gini), enflasyon oranı (Inf), işsizlik oranı (Unm) ve 2008 küresel ekonomik krizi kukla değişkeni (2008crs)) sağlık sistemlerinin teknik etkinliği üzerindeki etkisi araştırılmıştır. Çalışma 2000-2016 dönemini kapsamıştır.Bulgular: Analiz sonuçlarına göre, kişi başına düşen gelir arttıkça OECD ülkelerinde sağlık sistemleri teknik etkinliği istatistiksel olarak anlamlı bir şekilde artmaktadır. Ayrıca, işsizlik oranı ve gelir dağılımı adaletsizliği OECD ülkelerinin sağlık sistemlerinin teknik etkinliğini istatistiksel olarak anlamlı bir şekildeazaltmaktadır. Bunun dışında, sağlık sistemlerinde teknik etkinliğine enflasyon olumlu, 2008 küresel ekonomik krizi ise olumsuz etki etmiştir ancak bu değişkenlerin etkileri istatistiksel olarak anlamlı değildir.Özgünlük: Literatürde, bu çalışmanın kapsadığı yıllar kadar uzun bir dönemi kapsayan başka bir çalışmaya rastlanmamıştır. Bununla birlikte, çalışmanın kapsadığı yılların dönemlere ayrılması, dönemleri birbirleri ile kıyaslanabilir hale getirmiştir.
Patrón clínico y citogenético en pacientes con síndrome mielodisplásico en Cúcuta (Norte de Santander, Colombia).
Authors: Serrano Casas Juan Carlos , Varón Jaimes Carlos Roberto , Govin Ana Teresa , Celis Gabriel , Maldonado Luz Karine , Pacheco Javier
Published: June 2021

Los síndromes mielodisplásicos (SMD) son neoplasias clonales de pronóstico variable de acuerdo con estratificación. La citogenética es clave en diagnóstico y pronóstico. Población y métodos: en UHE estudiamos 81 pacientes con SMD. Caracterización clínica, laboratorio, IPSS-R, mortalidad, análisis citogenético con descripción de anomalías clonales típicas y atípicas de SMD. Resultados: la media etaria fue de 71 años, con predominio femenino. El subtipo más frecuente fue SMD con displasia multilinaje y displasia unilineal, y la manifestación más común fue anemia. Hubo mayor proporción de casos con riesgo bajo e intermedio (IPSS-R). La media de seguimiento no mostró diferencias entre grupos (p = 0,18). La sobrevida global a cinco años fue del 79%. La progresión a LMA se dio en un 9,8%. La mayor cantidad de decesos fueron en grupos de muy alto (85%) y alto riesgo (50%). La citogenética se presentó con el 72% de índice mitótico en 24 horas. El cariotipo clonal fue del 43% con 53 alteraciones de 81 estudios, siendo complejo en un 8,6%. Las anomalías numéricas y estructurales más frecuentes fueron: del(5q) y -Y 6,1%, del(20q), del(11q), del(17p) y +8 en el 3,7%. También, encontramos anomalías citogenéticas no típicas de SMD, como -22, -13-11, del(10q), 14p+, 15q+, en el 1,2%. Conclusiones: subtipos de SMD, citopenias, IPSS-R, mortalidad, alteraciones citogenéticas estructurales y numéricas guardan correlación con la literatura. La presencia de alteraciones citogenéticas atípicas plantea mayor evaluación y expansión en bases de datos internacionales.
Factor V Leiden y otras trombofilias, frecuencia en un centro de alta complejidad de Cali (Colombia).
Authors: Baena Juan Camilo , Murcia Angélica María , Franco María Alejandra , Moreno Isabella , Rosales Joaquín Donaldo , Castro Andrés , Pacheco Robinson
Published: June 2021

Objetivo: describir la frecuencia, características sociodemográficas y clínicas en pacientes adultos con sospecha de trombofilia con los siguientes diagnósticos: mutación factor V Leiden y G20210A de la protrombina, déficit de: proteínas C, S y antitrombina III, e hiperhomocisteinemia, en un hospital de alta complejidad en Cali (Colombia) entre 2011 y 2014. Métodos: se realiza un estudio de corte transversal, analizando los registros de pacientes a quienes se les evaluó la mutación factor V Leiden a través de rPCR. Se calculó la distribución de los datos en las variables numéricas utilizando la prueba de Shapiro-Wilk y se presentaron con medidas de tendencia central y dispersión según correspondiera. Los grupos se compararon a través de la prueba de Chi cuadrado o el test exacto de Fisher. Resultados: el factor V Leiden se presentó en el 8,4% de los pacientes con trombosis, todos heterocigotos. Los miembros inferiores, la retina y los accidentes cerebrovasculares representaron más del 70% de las trombosis. La alteración más frecuente en individuos con trombosis fue la hiperhomocisteinemia (34,4%), seguida de déficit de proteína S (19,8%), antitrombina III (11,3%), mutación G20210A de la protrombina (4,3%) y déficit de proteína C (2,7%). Conclusión: en este estudio la frecuencia de factor V Leiden y la mutación G20210A fueron menores a lo reportado por la literatura. Estas trombofilias no explican la mayoría de las trombosis idiopáticas que son evaluadas en la población. Es necesario efectuar un adecuado diagnóstico diferencial y estudiar la presencia de trombofilias en grupos de riesgo, a fin de identificar eventos adquiridos y disminuir complicaciones.
Supervivencia libre de eventos discriminada por riesgo citogenético en una cohorte colombiana con leucemia mieloide aguda primaria, tratados con inducción 7+3, seguida de consolidación con dosis altas de citarabina.
Authors: Gómez Ortiz Mauricio Efraín , Enciso Olivera Leonardo José
Published: June 2021

Introducción: la leucemia mieloide aguda (LMA) representa el 80% de las leucemias agudas en los adultosy tiene un sustrato en múltiples alteraciones genéticas, que son las principales determinantes del riesgoy pronóstico de la enfermedad, estableciendo tres grupos de riesgo citogenético: favorable, intermedioy desfavorable. Cambios en el tratamiento no han impactado en la supervivencia y la quimioterapia deinducción 7+3 seguida de consolidación con dosis altas de citarabina (HiDAC), que sigue siendo la estrategiaestándar con intención curativa. Fallar a la inducción, recaer o tener enfermedad mínima residualposterior a la inducción afectan negativamente la supervivencia.Materiales y métodos: presentamos un estudio descriptivo, retrospectivo de cohorte, para evaluar lasupervivencia libre de eventos (SLE): combinado entre falla a la inducción, recaída y muerte por cualquiercausa, discriminando los resultados por el riesgo citogenético en un grupo de pacientes colombianoscon LMA primaria no promielocítica, tratados con inducción 7+3 (Ida) más consolidaciones con HiDAC.Resultados: cincuenta y cinco pacientes fueron incluidos. A una mediana de 36 meses de seguimiento(12 a 56), el 54,5% presentó el evento combinado. La SG fue de 21,1 meses (10,2 a no alcanzada). LaSLE fue: 13,2 meses (7,2 a 31) y discriminada por riesgo citogenético: 16,5 vs. 13,2 vs. 1,8 meses para losriesgos favorable, intermedio y desfavorable, respectivamente; logrank: p = 0,00542.Conclusión: el riesgo citogenético afectó significativamente la supervivencia libre de eventos (falla ainducción, recaída o muerte) en una cohorte colombiana de pacientes con LMA primaria tratados conun esquema de quimioterapia estándar con intención curativa.
Relación entre linfocitos infiltrantes del tumor, índice neutrófilos/linfocitos y estadio clínico en pacientes con cáncer de mama triple negativo y HER2 positivo.
Authors: Mercuri Daniel , Mercuri Álvaro , Bravo Iván , Martínez Juan Pablo , Jaramillo Roberto , Cárdenas Luis Felipe , Ramírez Lisbeth , López Jorge Iván , Velasco Margarita
Published: June 2021

Introducción: los linfocitos infiltrantes del tumor (LIT) y el índice neutrófilos/linfocitos (INL) son biomarcadoresde respuesta inflamatoria que han mostrado tener valor pronóstico en cáncer de mama, especialmenteen subtipos triple negativo y HER2 positivo. Objetivo: determinar la relación entre la proporciónde LIT, INL y estadio clínico, en pacientes con carcinoma ductal infiltrante (CDI) de mama triple negativoo HER2 positivo en un instituto oncológico de Cali.Materiales y métodos: estudio transversal analítico. Se revisaron las historias clínicas y láminas histológicasde 120 pacientes femeninas con CDI de mama triple negativo y HER2 positivo diagnosticadas entre2015 y 2017. Se realizaron comparaciones por medio de prueba exacta de Fisher.Resultados: la mediana de edad fue 51 años, rango 23-88, el 94% de las pacientes tenían ECOG 0-1, el52% eran triple negativas, el 26% tenían enfermedad temprana; el 60%, enfermedad localmente avanzada;y el 14%, metastásica. La mediana de LIT estromales e INL derivado fue del 10% y 1,4, respectivamente,y el 11,3% de las pacientes tenían LIT estromales ≥50%. No se encontró relación del porcentaje de LITcon INL derivado o estadio clínico, aunque sí existe una tendencia a un INL derivado ≤1,4 en pacientescon LIT ≥50% (p = 0,053). Todas las pacientes con enfermedad metastásica presentaron una relación deINL derivado >1,4 (p = 0,017).Conclusiones: en pacientes con CDI de mama triple negativo y HER2 positivo, existe una relación entreINL elevado y presencia de enfermedad metastásica. No se halló asociación entre LIT y estadio clínico. Serequieren estudios adicionales que permitan determinar la utilidad de LIT como parámetro de pronósticoen cáncer de mama.
ISSUES OF INFORMATION ETHICS AND INFORMATION LAW IN THE GENERAL EDUCATION COURSE IN COMPUTER SCIENCE
Authors:   Moscow pedagogical state university, Moscow, Bosova L.L. , Samylkina N.N. ,   Moscow pedagogical state university, Moscow
Published: June 2021

The article analyzes the main approaches to the formation of digital competencies including issues of information ethics and law. Based on global approaches to the integration and building of digital skills in accordance with the level of education, a structure for the formation of basic ethical norms is proposed to ensure their own information security and increase awareness of their rights in the information sphere. The preschool period and all levels of general education are considered.
ON THE STYLE OF THINKING RELATED TO INFORMATIZATION OF EDUCATION
Authors:   Perm State National Research University, Perm, Henner Е.К.
Published: June 2021

The question of the style of thinking, which most reflects the results of informatization of education, is discussed. It is shown that such is the so-called "computational thinking", which contributes to solving problems in a highly developed information and educational environment. Computational thinking is the way people think in the digital age that can be useful (and for many it is) in the world of information technology and the massive involvement of computers in solving problems. For the formation of computational thinking, special efforts must be made, and they will be fruitful only in a highly developed information and educational environment created in the process of informatization of education. Computational thinking does not arise by itself - it must be purposefully shaped.
HISTORY OF COMPOSITE MATERIALS
Authors:   L.N. Gumilyov Eurasian National University, Nur-Sultan, Zhuzbayev S. , Adilova A. ,   L.N.Gumilyov Eurasian national university, Nur-Sultan, Kazakhstan, Akhmetzhanova Sh. ,   M. Auezov South Kazakhstan University, Shymkent
Published: June 2021

This article discusses the discovery and creation of composite materials, general characteristics and differences, structure, purpose of structural materials, a special combination of strength, stiffness and lightness, composite materials regardless of their origin, the result of volumetric combinations of various components, without individual components. properties, continuous component in the volume of composite materials - matrix, types of materials and their classification, composite building materials. Also reinforced building materials, the properties of many materials around us, their features, the properties of composite materials, their use in all fields of science, technology, industry, the ability to adjust the properties of composite materials using several matrices or fillers of different nature, the strength of the composite, hardness and deformation, composite materials with special properties.
USE OF COMPUTER TECHNOLOGIES IN THE STUDY OF PHYSICS
Authors:   Shakarim state University, Semey, Nurabayeva G.U. , Sydykova Zh.C. ,   Abai Kazakh National Pedagogical University, Almaty, Kabieva D.К. ,   Shakarim state University, Semey, Kovalkova U.А. ,   Shakarim state University, Semey
Published: June 2021

Мақалада физиканы оқыту процесінде компьютерлік технологияларды қолдану мәселесі қарастырылған. Оқушылардың АКТ қолдануы бойынша жұмыстарының әдістері мен тәсілдері, оқушылардың ақпараттарды өзбетінше іздеу және өңдеу құзіреттіліктерін қалыптастыру мәселесі берілген. Сондай-ақ, физика сабақтарында компьютерлік технологияны қолдануға мүмкіндік беретін негізгі міндеттер көрсетілген. Сонымен бірге, компьютерлік технологияны қолдануға мүмкіндік беретін негізгі міндеттерді шешудің әдістері көрсетілген. Көрсетілген әдістерді мектепте физика пәнін оқытуда қолдануға болады. Компьютерлік технологияларды сабақта қолдану қазіргі заманның талап-тілегіне, мақсаты мен міндетіне сай мәселе. Қазіргі заман ағымына қарай сабақта компьютерлік технологияларды қолдану арқылы мұғалім оқушылардың өзбеттерінше жұмыс істеу қабілеттерін, қиялы мен шығармашылық ойлау қабілеттерін арттыруға болады.
TO THE QUESTION OF LEARNING MODELING A NEURAL NETWORK IN SCHOOL COURSE OF INFORMATICS
Authors:   Abai Kazakh National Pedagogical University, Almaty, Issabayeva D.N. , Abdulkarimova G.A. ,   Abai Kazakh National Pedagogical University, Almaty
Published: June 2021

The article describes an approach to computer modeling of a neural network. To simulate a neural network, it is necessary to collect a large amount of data about the simulated object, identify its features, create an algorithm that is a set of operations performed on a computer. The function of neural networks is based on classification (sorting), prediction and recognition of objects or events. Modeling neural networks can be carried out by collecting data about an object, highlighting its distinctive features and creating an algorithm using the example of Iris-Fisher flowers. The article also includes a description of the execution of a neural network design task and the use of machine learning algorithms for data mining in an MS Excel spreadsheet processor for teaching lessons.
THE NEED FOR CLOUD TECHNOLOGIES IN THE EDUCATIONAL PROCESS
Authors:   K. Zhubanov Aktobe regional state University, Aktobe, Kulmagambetova Zh.K.
Published: June 2021

The article studies the concepts of cloud technologies, cloud storage systems, the advantages and disadvantages of which are determined by conducting a survey, a question and answer session between the faculty and students of the university. In addition, the effectiveness of the implementation of cloud technologies in the educational process of the university will be determined. The use of cloud technologies in higher educational institutions helps to reduce the problems of increasing the efficiency of the educational process. This demonstrates a significant reduction in data processing costs associated with educational institutions. The quality of user satisfaction will increase. In general, the use of cloud services is very effective for distance learning, online learning, especially in the current situation - a global pandemic.
TURISMO FRIKI, VOLUMEN I: TEMPLARIOS EN MALLORCA.
Authors: Barrera Cañellas Margarita , Melo Pereira Luciana , Wanderley Seabra de Melo Maria Augusta
Published: June 2021

El uso del patrimonio inmaterial como base de creación de nuevos productos de turismo cultural, es una forma de aprovechamiento económico y sostenible, que respeta no sólo el medio ambiente de los lugares de acogida, sino también su herencia, tradiciones y patrimonio histórico. En este entorno, observamos cómo nacen nichos de mercado turísticos cada vez más especializados y segmentados, que requieren de una atención específica, ya que se orientan al conocimiento de una determinada faceta singular de la cultura del lugar que visitan, conformando lo que se ha llamado “turismo friki”. Un ejemplo claro de lo descrito es el exponencial aumento en visitas que reciben en la actualidad todas aquellas localidades que han servido como escenarios cinematográficas de series y películas de éxito que explotan turísticamente aquello que las hace únicas. Proponemos entonces la creación en Mallorca de una ruta templaria, es decir, que recorra los enclaves templarios de la isla, conocida por su pasado histórico asociado a esta famosa orden militar, que goza de gran popularidad entre algunos sectores de la población como atestiguan los múltiples éxitos literarios relacionados de forma histórica o novelada con dicha orden militar.
Bimodal distribution of size-resolved particle effective density in a rural environment in the North China Plain
Authors: Zhou Yaqing , Ma Nan , Wang Qiaoqiao , Wang Zhibin , Chen Chunrong , Tao Jiangchuan , Hong Juan , Peng Long , He Yao , Xie Linhong , Zhu Shaowen , Zhang Yuxuan , Li Guo , Xu Wanyun , Cheng Peng , Kuhn Uwe , Zhou Guangsheng , Fu Pingqing , Zhang Qiang , Su Hang , Cheng Yafang
Published: June 2021

Abstract. Effective density is one of the most important physical properties of atmospheric particles. It is closely linked to particle chemical composition and morphology, and could provide special information on particle emissions and aging processes. In this study, size-resolved particle effective density was measured with a combined DMA-CPMA-CPC system in Multiphase chemistry experiment in Fogs and Aerosols in the North China Plain (McFAN) in autumn 2019. With a new developed flexible Gaussian fit algorithm, frequent (77–87 %) bimodal distribution of particle effective density is identified, with a low-density mode (named sub-density mode) accounting for 22–27 % of total observed particles. The prevalence of the sub-density mode is closely related to fresh black carbon (BC) emissions. The geometric mean for the main-density mode (eff,main) increases from 1.18 g cm−3 (50 nm) to 1.37 g cm−3 (300 nm) due to larger fraction of high-density components and more significant restructuring effect at large particle sizes, but decreases from 0.89 g cm−3 (50 nm) to 0.62 g cm−3 (300 nm) for the sub-density mode (eff,sub) ascribed to the agglomerate effect. eff,main and eff,sub show similar diurnal cycles with peaks in the early afternoon, mainly attributed to the increasing mass fraction of high material density components associated with secondary aerosol production, especially of secondary inorganic aerosol (SIA). To investigate the impact of chemical composition, bulk particle effective density was calculated based on measured chemical composition (ρeff,ACSM) and compared with the average effective density at 300 nm (eff,tot,300 nm). The best agreement between the two densities is achieved when assuming a BC effective density of 0.60 g cm−3. The particle effective density is highly dependent on SIA and BC mass fractions. The influence of BC on the effective density is even stronger than SIA, implying the importance and necessity of including BC in the estimate of effective density for ambient particles.
Hydrographic fronts shape productivity, nitrogen fixation, and microbial community composition in the southern Indian Ocean and the Southern Ocean
Authors: Hörstmann Cora , Raes Eric J. , Buttigieg Pier Luigi , Lo Monaco Claire , John Uwe , Waite Anya M.
Published: June 2021

Abstract. Biogeochemical cycling of carbon (C) and nitrogen (N) in the ocean
depends on both the composition and activity of underlying biological
communities and on abiotic factors. The Southern Ocean is encircled by a
series of strong currents and fronts, providing a barrier to microbial
dispersion into adjacent oligotrophic gyres. Our study region straddles the
boundary between the nutrient-rich Southern Ocean and the adjacent
oligotrophic gyre of the southern Indian Ocean, providing an ideal region to
study changes in microbial productivity. Here, we measured the impact of C
and N uptake on microbial community diversity, contextualized by
hydrographic factors and local physico-chemical conditions across the
Southern Ocean and southern Indian Ocean. We observed that contrasting
physico-chemical characteristics led to unique microbial diversity patterns,
with significant correlations between microbial alpha diversity and primary
productivity (PP). However, we detected no link between specific PP (PP
normalized by chlorophyll-a concentration) and microbial alpha and beta
diversity. Prokaryotic alpha and beta diversity were correlated with
biological N2 fixation, which is itself a prokaryotic process, and we detected
measurable N2 fixation to 60∘ S. While regional water masses
have distinct microbial genetic fingerprints in both the eukaryotic and
prokaryotic fractions, PP and N2 fixation vary more gradually and
regionally. This suggests that microbial phylogenetic diversity is more
strongly bounded by physical oceanographic features, while microbial
activity responds more to chemical factors. We conclude that concomitant
assessments of microbial diversity and activity are central to understanding
the dynamics and complex responses of microorganisms to a changing ocean
environment.
Retrieval of process rate parameters in the general dynamic equation for aerosols using Bayesian state estimation: BAYROSOL1.0
Authors: Ozon Matthew , Seppänen Aku , Kaipio Jari P. , Lehtinen Kari E. J.
Published: June 2021

Abstract. The uncertainty in the radiative forcing caused by aerosols and its effect on climate change calls for research to improve knowledge of the aerosol
particle formation and growth processes. While experimental research has
provided a large amount of high-quality data on aerosols over the last 2 decades, the inference of the process rates is still inadequate, mainly due to
limitations in the analysis of data. This paper focuses on developing
computational methods to infer aerosol process rates from size distribution
measurements. In the proposed approach, the temporal evolution of aerosol
size distributions is modeled with the general dynamic equation (GDE) equipped with
stochastic terms that account for the uncertainties of the process rates. The
time-dependent particle size distribution and the rates of the underlying
formation and growth processes are reconstructed based on time series of
particle analyzer data using Bayesian state estimation – which not only
provides (point) estimates for the process rates but also enables quantification of
their uncertainties. The feasibility of the proposed computational framework
is demonstrated by a set of numerical simulation studies.
Sea Surface Salinity Short Term Variability in the Tropics
Authors: Bingham Frederick , Brodnitz Susannah
Published: June 2021

Abstract. Using data from the Global Tropical Moored Buoy Array we study the validation process for satellite measurement of sea surface salinity (SSS). We compute short-term variability (STV) of SSS, variability on time scales of 5–14 days. It is meant to be a proxy for subfootprint variability as seen by a satellite measuring SSS. We also compute representation error, which is meant to mimic the SSS satellite validation process where footprint averages are compared to pointwise in situ values. We present maps of these quantities over the tropical array. We also look at seasonality in the variability of SSS and find which months have maximum and minimum amounts. STV is driven at least partly by rainfall. Moorings exhibit larger STV during rainy periods than non-rainy ones. The same computations are also done using output from a high-resolution global ocean model to see how it might be used to study the validation process. The model gives good estimates of STV, in line with the moorings, though tending to have smaller values.
Perceptions of School-Based Telehealth in a Rural State: Moving Forward After COVID-19
Authors: Hermes Susan Skees , Rauen Jade , O'Brien Shirley
Published: June 2021

The purpose of this study was to discern the barriers faced by school-based clinicians, chiefly occupational therapists (OTs) and speech-language pathologists (SLPs) who provided telehealth in a primarily rural state during an unexpected declaration of a state of emergency in response to the COVID-19 pandemic. Survey results found the major barriers to implementation of telehealth services to be lack of practitioner training, a lack of access to technology for students, and concerns that the quality of intervention might not be equivalent to in-person service delivery. This article discusses both the benefits and barriers to providing telehealth services in school-based practice and offers considerations for future studies on this topic.
Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19
Authors: Bican Rachel , Christensen Catie , Fallieras Kristin , Sagester Grace , O'Rourke Sara , Byars Michelle , Tanner Kelly
Published: June 2021

The COVID-19 pandemic necessitated a sudden limitation of in-person outpatient occupational and physical therapy services for most patients at a large, multisite pediatric hospital located in the Midwest, United States.  To ensure patient and staff safety, the hospital rapidly shifted to deliver most of these services via telerehabilitation. The purposes of this study were to (1) describe the rapid implementation of telerehabilitation during the COVID-19 pandemic, (2) describe the demographic characteristics of patients who continued in-person services and those who received telerehabilitation, and (3) evaluate the therapists’ perceptions of telerehabilitation for physical and occupational therapy. Most of the children (83.4% of n=1352) received telerehabilitation services. A family was more likely to choose to continue in-person visits if their child was <1-year-old, had a diagnosis of torticollis, received serial casting, or was post-surgical. Occupational and physical therapy therapists (n=9) completed surveys to discern their perceptions of the acceptability of telerehabilitation, with most reporting that telerehabilitation was as effective as in-person care.
Telerehabilitation for Post-Hospitalized COVID-19 Patients: A Proof-of-Concept Study During a Pandemic
Authors: Tanguay Pamela , Marquis Nicole , Gaboury Isabelle , Kairy Dahlia , Touchette Matthieu , Tousignant Michel , Décary Simon
Published: June 2021

Purpose: Telerehabilitation could prevent sequelae from COVID-19. We aimed to assess the feasibility of telerehabilitation; describe pulmonary and functional profiles of COVID-19 patients; and explore the effect of telerehabilitation on improving pulmonary symptoms and quality of life. Methods: We conducted a pre-experimental, pre-post pilot study. We recruited COVID-19 patients who had returned home following hospitalization. The intervention included eight weeks of supervised physiotherapy sessions. We documented technological issues, success of recruitment strategies, and participants’ attendance to supervised sessions. We measured the impact of pulmonary symptoms on quality of life and functional health. Results: We scheduled 64 supervised sessions with seven participants with few technological issues. Initial scores showed that pulmonary symptoms moderately to highly impacted quality of life. At eight weeks, all patients had improved from 10 to 45 points on the EuroQol-Visual Analog Scale (EQ-VAS) instrument, indicating clinical significance. Conclusion: We developed and administered a telerehabilitation intervention during a global pandemic that targets key symptoms of the relevant disease.
A Normative Approach to Valuation, Value Enhancement and Financial Statement Reporting of Intellectual Capital
Authors:   United International College, Beijing Normal University and Hong Kong Baptist University, So Michael , Ratnatunga Janek
Published: June 2021

Intellectual capital (IC) is increasingly seen as an integral part of a firm’s value-creating processes and an essential strategic asset in creating corporate sustainable competitive advantage (Bukh, 2003; Chen, Cheng & Hwang, 2005). Nevertheless, reporting on IC is currently inconsistent, incomparable, and incomplete because of a lack of consistent guidance. This paper presents a normative IC valuation and reporting framework based on the Capability Economic Value of Intangible and Tangible Assets (CEVITA) approach (Ratnatunga, Gray & Balachandran, 2004). The proposed framework enables the application of CEVITA to the valuation of intellectual capital capability and provides a theoretical foundation for future empirical studies in relation to IC valuation and reporting.
The Role of Strategic Cost Management in Marketing Decisions: A Case Evidence of Brand Acquisition Assessment
Authors:   Institute of Certified Management Accountants, Manapat Richard Kristoffer S. ,   Philippine Institute of Certified Public Accountants, Sridharan V. G. ,   Adelaide Business School, The University of Adelaide
Published: June 2021

While the role of strategic cost management (SCM) is heralded to pervade through all the links in a firm’s value-chain (Anderson, 2006; Shank & Govindarajan, 2004) the specific role of SCM in relation to a firm’s marketing function has thus far been limited to a few areas such as product pricing and analysing customer profitability through activity-based cost allocations (Datar & Rajan, 2018; Foster & Gupta, 1994; Van Raaij, 2005). This paper presents a case study to show how SCM concepts can be extended to evaluate brand acquisition by a large organisation. Using shareholder value analysis for pricing the brand and combining with financial statement analysis and strategic positioning models such as Porter’s five forces and SWOT, this paper conducts an assessment in order to offer recommendations for a multi-billion peso investment of a large Philippine-based processed foods company seeking to acquire a new brand.
XÁC ĐỊNH ĐỘT BIẾN TRÊN EXON 8, 10 CỦA GEN CDH1 Ở BỆNH NHÂN UNG THƯ DẠ DÀY LAN TỎA DI TRUYỀN
Authors: Thủy Hán Minh , Ngọc Phạm Thiện , Ngọc Dung Đặng Thị
Published: June 2021

Đặt vấn đề: Ung thư dạ dày (UTDD) là căn bệnh áctính đứng hàng thứ năm và là nguyên nhân thứ ba gây tửvong do ung thư trên toàn thế giới. Ung thư dạ dày thể lantỏa theo Lauren được đặc trưng bởi tuổi khởi phát sớm, sựbiệt hóa kém, tiến triển bệnh nhanh, tỉ lệ di căn cao. GenCDH1 mã hóa protein E-cadherin, được coi là một genức chế khối u liên quan đến sự khởi đầu và tiến triển củaUTDD thể lan tỏa và UTDD lan tỏa di truyền (HDGC).Đột biến soma gen CDH1 cũng là 1 trong các cơ chế phântử thứ 2 làm bất hoạt alen của của gen CDH1. Vùng haygặp đột biến nằm từ exon 7 đến exon 10. Mục tiêu: Xácđịnh đột biến trên exon 8, 10 của gen CDH1 ở bệnh nhânung thư dạ dày lan tỏa di truyền. Đối tượng và phươngpháp: Nghiên cứu mô tả cắt ngang trên 42 bệnh nhân đápứng tiêu chuẩn của Hiệp hội Liên kết ung thư dạ dày vềUTDD lan tỏa di truyền tại Bệnh viện Đại học Y Hà Nội,Viện K-cơ sở Tân Triều, Bệnh viện Hữu nghị Việt Đức,từ tháng 8/2018 đến tháng 8/2020 được lấy mẫu mô ungthư và giải trình tự tìm đột biến gen. Kết quả: Phát hiệnđược 2 đột biến sai nghĩa chiếm 4,76% trong tổng số 42bệnh nhân nghiên cứu bao gồm 1 đột biến mới 1039G >A, thay thế acid amin Alanin thành Threonin và 1 đột biếnđã công bố 1018A > G biến đổi Threonin thành Alanin.Không phát hiện đột biến nào trên exon 10. Kết luận: Cầntiến hành nghiên cứu với cỡ mẫu lớn hơn kết hợp phântích invitro và nhuộm hóa mô miễn dịch gen CDH1