bluuebunny/crossref_metadata_2025 huggingface dataset:
Iron Seller Activities in Riverbank Communities in South Kuin Village
Authors: Radjikan Febrian Putra Anugrah , Syaharuddin Syaharuddin , Handy Muhammad Rezky Noor , Nur’aini Fatwa , Rusmaniah Rusmaniah
Published: November 2024

The background of the iron sellers in the riverbank is a human unit or group of people living in along the riverbank.  Their lives are dominated by river culture.  However, the life of the Bantaran Sungai community in Kuin Selatan Village, Banjarmasin, gives a different and very interesting nuance.  There are forms of economic activity in the area that indirectly do not influent in the river for the spring of life, but present a complete form of economic activity, both from production and distribution and consumption activities.  This is reflected in the economic activity of iron craftsmen. The points at this research were: (1.) To discover out what kinds of goods were made by iron sellers in Kuin Selatan Village, (2.) To find out the making, marketing and usage activities take out by iron sellers at Kuin Selatan Village, (3.) To discover out the ways of making iron by iron sellers. Descriptive qualitative method was used in the research to illustrate the economic activities of the riverbank groups in Kuin Selatan Village.  The person in this research were iron craftsmen.  The research instrument consisted of observation guides and interviews made by the researchers themselves.  The data analysis technique used is data reduction, data presentation and conclusion.  Test the validity of the data using time triangulation, sources and data collection techniques.The conclusions appear that the interesting economic activity of the riverbank groups in Kuin Selatan Town was ironmonger.  Its economic activities contain: (1.) production activities, (2.) marketing activities, (3.) usage activities.  The making activities of the iron craftsmen are in the form of agricultural tools such as hoes, crowbars, machetes, sickles, and also in the form of household utensils such as frying pans, knives and panicles.  In addition, other products include bolts, drills, truck elbows, hinges, valves, drums and containers.  Distribution activities can be seen in the acquisition of raw materials and distribution of production results to consumers.  The form of distribution of goods is carried out directly or indirectly.  Obtaining nail materials indirectly through collectors, while the distribution of manufactured goods through agents.  The consumption activities of iron craftsmen are carried out directly, namely buyers come directly to the craftsmen to buy the goods they produce and indirectly, namely traders buy to be resold to the market to consumers. The conclusion reached by these iron sellers is that we can get to know the processing of iron goods which can be made into several kinds of tools to break down gold such as drums and valves for example, accompanied by activation of production, distribution and consumption
The Influence of Self Cofidence in Public Speaking
Authors: Eni Nur , Warastri Nasywa Tsany , Mutiani Mutiani , Ilhami M. Ridha , Sari Raihanah
Published: November 2024

This journal article discusses the influence of self-confidence on public speaking skills in adolescents. This article finds interesting facts that social interaction with the environment and even includes support from peers, family, and teachers, plays an important role of one's self in shaping and increasing one's self-confidence. From the results of the interviews and questionnaires that we distributed, it can be concluded that for someone to improve their public speaking skills, efforts are also needed to strengthen and increase their confidence through positive social interaction and also support from the surrounding environment. From this article, it is hoped that it can contribute even to the development of educational strategies as well as effective interventions to improve public speaking skills in everyone. The research methods used include interviews and questionnaire distribution. The questionnaire was distributed to collect quantitative data on the level of confidence and its influence on public speaking skills. The results of our study show that self-confidence has a significant role in determining a person's success in public speaking. A person with a high level of confidence tends to be better able to overcome fear and anxiety, and is more effective in conveying their message to the audience. The hope of the discussion in this article is that we can all learn and even understand that there are causes and effects experienced by others that are certainly different from what we experience. So that we can also learn to see someone's reasoning from another point of view.
PENGEMBANGAN LKPD BERNUANSA ETNOMATEMATIKA PERMAINAN TRADISIONAL BATEWAH PADA MATERI TEOREMA PYTHAGORAS
Authors: Hayati Hafidzna , Fajriah Noor , Kamaliyah Kamaliyah
Published: November 2024

Kalimantan Selatan merupakan daerah yang kaya akan ragam budaya, salah satunya adalah permainan tradisional batewah. Permainan tradisional batewah perlu diperkenalkan kepada peserta didik untuk menumbuhkan sikap menghargai dan menumbuhkan kecintaan terhadap budaya. Pengembangan LKPD bernuansa etnomatematika permainan tradisional batewah merupakan sarana untuk mendukung pembelajaran dan sebagai bentuk upaya meningkatkan rasa menghargai dan kecintaan peserta didik terhadap kebudayaan khususnya budaya yang ada di sekitar mereka. Penelitian pengembangan ini bertujuan untuk menghasilkan LKPD bernuansa etnomatematika permainan tradisional batewah pada materi teorema Pythagoras yang valid, praktis, dan efektif. LKPD dikatakan valid berdasarkan penilaian validator, LKPD dikatakan praktis berdasarkan lembar angket respons peserta didik setelah menggunakan LKPD, selanjutnya LKPD dikatakan efektif berdasarkan hasil belajar peserta didik setelah mengerjakan LKPD. Penelitian pengembangan ini menggunakan model pengembangan Plomp yang terdiri dari fase investigasi awal, fase perancangan, fase realisasi/konstruksi, serta fase tes, evaluasi, dan revisi. Hasil uji kevalidan LKPD oleh tiga validator diperoleh skor 3,69 dengan kriteria sangat valid. Hasil uji kepraktisan dengan 25 peserta didik diperoleh skor 3,78 dengan kriteria sangat praktis. Hasil uji keefektifan diperoleh skor 80% dengan kriteria efektif. Dengan demikian, dihasilkan perangkat ajar berupa LKPD bernuansa etnomatematika permainan tradisional batewah pada materi teorema Pythagoras yang valid, praktis dan efektif.
Alternative technologies of composite highly loaded aircraft structures: a qualitative method of making multi-criteria decisions. Comprehensive presentation: Part IV. Equilibrium and stability of the dynamic model of the ADS
Authors: Zabashta Volodymyr
Published: November 2024

The main direction of the fourth part of the work is the study of an autonomous dynamic system in the field of aviation technology, based on the provisions of the qualitative theory of differential equations with the involvement of the phase portrait method. The materials and results of the article are based on the starting points in the decision-making problem (DPR), specified [1], [3] empirically - the formalized direction of research in the comparison of preprego - autoclaved (surfactant) and non-autoclaved VARTM technologies in the manufacture of carbon-plastic aircraft structures according to the prevalence (first of all - quality) (AK) type of highly loaded stringer panels of the wing caisson (VSP) of mainline aircraft. That is, we are talking about a large multi-stage (based on ChTP) technological system. The research as a whole is based on systems analysis (SA) and interpreted structure-functional modeling of ATP. The evaluation toolkit and criterion-evaluation apparatus based on the macro-level ADS and a number of technological structures and other configurations are used [2]. Special points, stability and phase portrait of ADS (quadratic function) were investigated, with the involvement of interpreted elements of the topology of many species, as well as bifurcation points of the system.
Unified Model for Predicting the Size and Shape Dependent Cohesive Energy and Melting Temperature of Semiconducting Nanomaterials
Authors: Berry Habte Dulla , Sherka Gebru Tesfaye , Zhang Qinfang
Published: November 2024

Predicting the thermophysical properties of designed materials at the nanoscale is crucial. However, this remains a significant challenge despite numerous efforts by researchers and scientists. This paper presents a unified thermodynamic model to study the size and shape-dependent cohesive energy, as well as the melting temperature of semiconductor nanosolids, including InSb, ZnSe, CdS, and CdSe. The model provides insight into the thermal stability of nanosolid materials by considering the combined impact of size, shape, and packing density. The finding indicates that smaller nanoparticles exhibit a lower cohesive energy compared to larger ones. Our unified thermodynamic model yields results consistent with experimental values and demonstrates a closer agreement than those from the universal liquid drop model of size-dependent cohesive energy, which includes a shape factor of α = 2/3 for nanowires. According to the results, the melting temperature of nanoparticles drops as their size decreases. Below a diameter of 5 nm, this trend becomes more noticeable. In the nano-scale domain, the nanoparticle's shape also matters greatly. In particular, compared to tetrahedral nanoparticles, nanowires show a lesser reduction in melting temperature. Also, up to a diameter of roughly 10 nm, the melting temperatures of these nanoparticles rise with particle size. The search results show that, especially in the < 5 nm size range, the size and shape of nanoparticles significantly affect their melting point. The models accurately predict the relationship between particle size and melting point for various semiconductor nanomaterials, aligning with experimental findings. Interestingly, the information points to a potential preference for these nanomaterials to form nanowire structures in the < 5 nm size range. Our research offers helpful insights into the thermophysical properties of these semiconducting materials, which may have significant implications for their use in a diversity of technological applications.
The Role of AI in Mental Health: Breaking Down Barriers for Men
Authors: kate Benjamin
Published: November 2024

This article examines the transformative role of artificial intelligence (AI) in mental health, with a particular focus on its potential to break down barriers for men facing mental health challenges. Historically, men have been less likely to seek help for mental health issues due to societal stigma, cultural expectations, and a reluctance to express vulnerability. AI technologies, including chatbots, generative AI, and machine learning algorithms, offer innovative solutions to address these challenges by providing accessible, anonymous, and personalized support. This paper explores how AI-powered mental health applications can create safe spaces for men to engage with their emotions, seek help, and access resources tailored to their specific needs. Furthermore, it highlights the importance of integrating AI into traditional mental health care models to enhance outreach and reduce stigma. By fostering a more inclusive approach to mental health support, AI has the potential to empower men, promote emotional resilience, and ultimately improve mental health outcomes in this underserved demographic.
A Case Of Successful Dupilumab Treatment In Allergic Rhinitis And Atopic Dermatitis In Patient With Multiple Food Allergies, Pollen And Perennial Sensitization
Authors: Sculco Eleonora , Garzi Giulia
Published: November 2024

Dupilumab is an interleukin 4 (IL-4) receptor α-antagonist that inhibits IL-4 and IL-13 signaling through blockade of the shared IL-4αR subunit. Blockade of IL-4/13 is effective in reducing Th2-oriented response including the release of proinflammatory cytokines, chemokines, and IgE. These mechanisms are known as mediators in the pathogenesis of atopic dermatitis, food allergy, allergic rhinitis with and without polyposis, and asthma. We report the clinical case of a patient in which the Th2-mediated inflammatory substrate is evident in comorbid allergic manifestations who show a good response after treatment with Dupilumab for moderate atopic dermatitis
Synthesis of Antibacterial Norlabdane Compounds with Rearranged Cycle B and Molecular Docking Studies
Authors: Ciocarlan Alexandru , Lungu Lidia , Shova Sergiu , Vornicu Nicoleta , Bolocan Natalia , Kulcițki Veaceslav , Aricu Aculina
Published: November 2024

The synthesis of tetra- and pentanorlabdane compounds with rearranged cycle B based on commercially available (+)-sclareolide is reported. Desired compounds were prepared from intermediate ketones via Baeyer-Villiger oxidation. The structures of synthesized compounds were confirmed by spectral IR, 1D (1H, 13C and 15N, DEPT) and 2D (H-COSY, H,C-HSQC, H,C-HMBC, H,N-HMBC, NOESY) NMR analyses, mass-spectrometry and single crystal X-rays diffraction. Two of the four obtained compounds showed high antifungal and antimicrobial activity, comparable and exceeding that of standards Caspofungin and Kanamycin. DFT calculations revealed the stability of compounds in gas, DCM, water and methanol. Molecular docking to four targets (1KZN, 1U1Z, 3QLS, 2Q85) showed good agreement with the results of in vitro evaluation and confirmed the biological activity of compounds 3 and 4, with binding affinities comparable and for some targets exceeding that of Caspofungin and Kanamycin.
Nk Cells Secreted Ifn-γ and Tnf-α Mediated Differentiation in Lung Stem-Like Tumors Leading to Susceptibility of Tumors by Chemotherapeutic Drugs
Authors: Kaur Kawaljit , Celis Angie Suleny , Jewett Anahid
Published: November 2024

We demonstrate that natural killer (NK) cells induce higher cytotoxicity against lung cancer stem-like cells (hA549) compared to differentiated lung cancer cell lines (H292). The supernatants from split anergized NK cells (NK cells treated with IL- and anti-CD16 mAbs) induced differentiation in hA549. Differentiated lung cancer cell lines (H292) and NK cell differentiated hA549 expressed reduced NK cell-mediated cytotoxicity but expressed higher sensitivity to chemotherapeutic drugs. This finding validated our previous reports demonstrating that the levels of NK cell-mediated cytotoxicity and sensitivity to chemotherapeutic drugs correlate directly and indirectly, respectively, with the stage and levels of tumor differentiation. We also demonstrate the role of IFN-γ and TNF-α in inducing tumor differentiation. NK cells’ supernatants or IFN-γ and TNF-α-induced tumor differentiation was blocked when we used antibodies against IFN-γ and TNF-α. Therefore, IFN-γ and TNF-α secreted from NK cells play a crucial role in tumor differentiation resulting in increased susceptibility in tumors to chemo-therapeutic drugs. We also observed different effects of MHC-class I antibodies in CSCs vs. differentiated tumors. Treatment with anti-MHC-class I decreased NK cell-mediated cytotoxicity in hA549 whereas, the increased NK cell-mediated cytotoxicity was seen when differentiated tumors were treated with antibodies against MHC-class I.
3D Printing of New Foods Using Cellulose‐Based Gels Obtained from Cerotonia siliqua L. Byproducts
Authors: Capellà Antoni , Umaña Mónica , Dalmau Esperanza , Cárcel Juan A. , Femenia Antoni
Published: November 2024

Carob pulp is a valuable source of cellulose-rich fraction (CRF) for many food applications. This study aimed to obtain and characterize a CRF derived from carob pulp waste, after sugar removal, and to evaluate its potential use in the 3D printing of cellulose-rich foods. Thus, extraction of the CRF present in carob pulp (by obtaining the alcohol-insoluble residue) was carried out, accounting for nearly 45 % dm (dry matter) of this by-product. The CRF contained about 24 % dm of cellulose. The functional properties (swelling capacity, water retention and fat adsorption) related to this fraction were determined, which showed a value of 5.9 mL/g of CRF, 4.0 and 6.5 g/g of CRF, respectively. Different gels were formulated with a total solids content of 15 % wm (wet matter), using potato peel flour as a base and partially substituting with CRF (0-8 % wm). The cellulose-based gels were characterized in terms of viscosity, water distribution (low-field NMR), and printability, while the 3D-printed samples were assessed for their textural properties. As the percentage of added CRF increased, the viscosity decreased while the water retention increased. Printability improved when small proportions of CRF (2-4%) were used, while deteriorated for higher percentages (6-8 %). The textural properties (hardness, adhesiveness, cohesiveness, and gumminess) showed significant changes caused by the addition of CRF, with gels containing 3-4 % CRF exhibiting the most suitable printing values. In summary, CRF extracted from carob pulp waste can be used as an ingredient in the 3D printing of novel cellulose-rich foods, reducing food waste within the framework of the circular economy.
Spirometry Plays a Limited Role in Assessing Lung Disease in Children with Newly Diagnosed Rheumatic Conditions
Authors: Prountzos Spyridon , Chiotopoulou Kyveli , Kourtesi Katerina , Sapountzi Evdoxia , Moriki Dafni , Kartsiouni Elpiniki , Alexopoulou Efthymia , Douros Konstantinos , Fotis Lampros
Published: November 2024

Introduction: Lung involvement in pediatric rheumatic diseases significantly impacts morbidity and mortality. High-resolution computed tomography (HRCT) is a sensitive diagnostic tool for detecting lung involvement; however, it raises concerns regarding radiation exposure. Spirometry, a non-invasive and widely accessible test, is often used to assess pulmonary function, but its accuracy in identifying lung disease in children with newly diagnosed rheumatic conditions remains uncertain. This study evaluates the reliability of spirometry, using HRCT as the reference standard, in detecting early lung involvement in this population.
Methods:
At our institution, all patients suspected of having lung involvement—either due to respiratory symptoms or the high prevalence of respiratory involvement associated with their specific disease—underwent an HRCT scan and pulmonary assessment. A retrospective review of HRCT scans was conducted for 22 pediatric patients diagnosed with rheumatic disease between January 2021 and December 2023, all of whom exhibited pathological findings in their HRCT scans. HRCT scans were conducted with a paired end-inspiratory and forced-expiratory protocol using 1-mm collimation. Radiological findings, including parenchymal opacities, ground-glass opacities (GGOs), reticular patterns, honeycombing, parenchymal bands, bronchiectasis, peribronchial wall thickening, and air trapping were assessed. Spirometric values, including percent predicted values for Forced Expiratory Volume in 1 second (ppFEV1), Forced Vital Capacity (ppFVC), and the FEV1/FVC ratio, were collected for all patients who had an acceptable flow-volume curve
Results:
Of the 22 patients enrolled, 17 (77.3%) had technically acceptable spirometry results. Using HRCT as the reference standard, spirometry yielded a sensitivity of 29.4%.
Conclusion:
Although spirometry demonstrated excellent positive predictive value, its low sensitivity indicates that it may miss early lung involvement in children with newly diagnosed rheumatic diseases. These findings reinforce HRCT as the preferred diagnostic tool in this population, despite concerns about radiation exposure, to ensure accurate detection and management of lung involvement.
Comparison of Graphites Intercalated with Fluorine as Slow Neutron Reflectors
Authors: Clavier Batiste , Czamler Valentin , Dubois Marc , Henry Killian , Nesvizhevsky Valery , Petit Elodie
Published: November 2024

The use of neutron reflectors is an effective method for improving the quality of neutron sources and neutron delivery systems. In this work, we further develop the method based on Bragg scattering of neutrons in crystals with large interplanar distances. We compare samples of differently prepared fluorine intercalated graphites by measuring the total cross section for the interaction of neutrons with the samples, depending on the neutron wavelength. The Brag scattering cross section is the dominant part of the total cross section in all the cases. The results show that all samples provide high reflection efficiency over the entire range of the so-called “neutron reflectivity gap” and beyond it, and also allow choosing the optimal intercalation methods.
High-performance PZT Piezoelectric Ceramic Materials for Photocuring 3D Printing
Authors: Gao Weiwei , Xu Ze , Wang Ke
Published: November 2024

The application of photopolymerization 3D printing technology in the field of piezoelectric ceramics can achieve high precision, customization, and personalized design of piezoelectric ceramics, providing a better technical means for the fine processing of ceramic materials. We have studied the preparation of PZT piezoelectric ceramic 3D printing slurry, as well as the analysis of forming errors of printed green bodies, debinding process, and sintering. We successfully printed and sintered various porous honeycomb structures of D-type and G-type using a PZT slurry with a solid content of 55 wt.%.
Revolutionizing Crypto Forecasts: Deep Learning and Sentiment Synergy for Price Prediction
Authors: Saadatmand Fatemeh , Semyari Reza , Jahanbin Kia
Published: November 2024

Predicting stock and cryptocurrency prices is challenging. One method involves ana-lyzing opinions from individuals and experts. This article focuses on analyzing social media sen-timents for predicting Bitcoin prices using various criteria. In this article, unlike other articles that only used the points obtained from sentiment analysis of tweets, we combined the points of tweets based on other criteria, such as the highest like counts, the highest volume of tweets, and the weighted scores of tweets. In the first stage, we evaluated the deep learning models SL, LG, LGC, BL, and BG without considering sentiment. Ultimately, the BG model performed well in evaluation metrics such as MAE and Loss. In the second stage, we examined the impact of tweet volume on the models' performance. In the third stage, we utilized the simulation results of the VADER model. For the fourth stage, we considered the maximum likes for tweets as a sentiment analysis tool.
Finally, in the last stage, which is the main focus of this article, we employed weighted averaging for sentiment analysis. Model BG provided approximately 11% improvement based on the MAE metric and about 15% improvement based on the Loss metric for better detection the following day.
Effect of Sevoflurane Combined with Propofol Continuous Anaesthesia on Anaesthetic Outcome and Postoperative Analgesia and Recovery in Elderly Patients Undergoing Lower Limb Fracture Surgery
Authors: Zhao Lu , Hou Jun-de , Chen Yong-xue , Wang Zhi-gang , Wang Xiao-ru , Chen Shi-huan , Li Li-ying , Wei Xiao-na
Published: November 2024

Objective: To investigate the effects of sevoflurane combined with propofol continuous anaesthesia on anaesthesia and postoperative analgesia and recovery in elderly patients undergoing lower limb fracture surgery.Methods: In this study, 344 elderly patients who underwent surgical treatment for lower limb fractures in our hospital between June 2020 and May 2022 were enrolled for prospective analysis, and the patients were equally divided into a control group and an experimental group by the random number table method, with 172 patients in each group.In the control group, continuous anaesthesia with propofol was used, while in the experimental group, continuous anaesthesia with sevoflurane and propofol was used. The anesthetic effect, postoperative analgesic effect, recovery effect and adverse reactions of the patients in the two groups were compared.Results: The excellent anesthesia rate in the experimental group was significantly higher than that in the control group (P<0.05); VAS scores at T1, T2, T3 and T4 were significantly lower in the experimental group than in the control group (P>0.05); Time to awaken, time to extubation and time to leave the anesthesia recovery room were all significantly lower in the experimental group than in the control group (P<0.05); The difference in the incidence of postoperative adverse reactions between the two groups was not statistically significant (P>0.05).Conclusion: Sevoflurane combined with propofol continuous anaesthesia is ideal for anaesthesia in elderly patients undergoing lower limb fracture surgery. This protocol is effective in suppressing postoperative pain and facilitating recovery from anaesthesia and does not increase the risk of postoperative adverse effects in patients.
Novel Lipid-Based Carriers of Provitamin D3: Synthesis and Spectroscopic Characterization of Acylglycerol Conjugated with 7-Dehydrocholesterol Residue and its Glycerophospholipid Analogue
Authors: Gładkowski Witold , Ortlieb Susanna , Niezgoda Natalia , Chojnacka Anna , Fortuna Paulina , Wiercik Paweł
Published: November 2024

Two novel lipids, acylglycerol and glycerophospholipid containing succinate-linked provitamin D3 at sn-2 position of glycerol backbone, have been synthesized from dihydroxyacetone (DHA) and sn-glycerophosphocholine (GPC), respectively. Three-step synthesis of 1,3-dipalmitoyl-2-(7-dehydrocholesterylsuccinoyl)glycerol involved esterification of DHA with palmitic acid, reduction of carbonyl group and conjugation of resulting 1,3-dipalmitoylglycerol with 7-dehydrocholesterol hemisuccinate (7-DHC HS). Using NaBH3CN as a reducing agent was crucial to avoid any acyl migration and obtain the final product with 100% regioisomeric purity. 1-Palmitoyl-2-(7-dehydrocholesterylsuccinoyl)-sn-glycero-3-phosphocholine was produced in two-step process by the esterification of GPC at sn-1 position with palmitic acid and subsequent conjugation of 1-palmitoyl-sn-glycero-3-phosphocholine with 7-DHC HS. Apart from the main product, some amount of its regioisomer containing provitamin D3 linked at sn-1 position and palmitic acid at sn-2 position was detected which indicated the acyl migration of palmitic acid from sn-1 to sn-2 position in the intermediate 1-palmitoyl-sn-glycerophosphocholine. Synthesized novel lipids were fully characterized by spectroscopic data. They can find application as novel lipid-based prodrugs as the additives to sunscreen creams, providing controlled release of provitamin D3 in the epidermis.
Ulcerative Colitis, LAIR1 and TOX2 expression and Colorectal Cancer Deep Learning Image Classification Using Convolutional Neural Networks
Authors: Carreras Joaquim , Roncador Giovanna , Hamoudi Rifat
Published: November 2024

Background: Ulcerative colitis is a chronic inflammatory bowel disease of the colon mucosa associated with a higher risk of colorectal cancer. Objective: This study is a proof-of-concept analysis aimed to test the feasibility of classifying hematoxylin and eosin (H&E) histological images of ulcerative colitis, normal colon, and colorectal cancer using Artificial Intelligence (AI); Methods: A convolutional neural network (CNN) was designed and trained to classify the 3 types of diagnosis, including 35 cases of ulcerative colitis (n = 9,281 images), 21 colon control (n = 12,246), and 18 colorectal cancer (n = 63,725). The data were partitioned into training (70%) and validation sets (10%) for training the network, and a test set (20%) to test the performance on the new data. Explainable artificial intelligence for computer vision was performed using gradient-weighted class activation mapping (Grad-CAM) to understand the classification decisions; and additional LAIR1 and TOX2 immunohistochemistry was performed in ulcerative colitis to analyze the immune microenvironment; Results: The trained network classified the 3 diagnoses with high performance. The model classified ulcerative colitis with an accuracy of 99.1%, precision of 97.1%, recall of 94.8%, an F1-score of 95.9%, and specificity of 99.6%. For colorectal cancer, the performance was as follows: accuracy, 99.8%; precision, 99.9%; recall, 99.8%; F1-score 99.9%; and specificity, 99.7%. The Grad-CAM heatmap confirmed which parts of the image were most important for classification. The CNN also managed to differentiate between steroid-requiring (SR) and nonsteroid requiring (non-SR) ulcerative colitis based on H&E, LAIR1 and TOX2 staining; Conclusions: Convolutional neural networks are essential tools for deep learning and are especially suited for image recognition in conditions such as ulcerative colitis and colorectal cancer; LAIR1 and TOX2 are promising immuno-oncology markers in ulcerative colitis.
Examining the Relationship between Stand Density of Declining White Oaks (Quercus alba L.) and Soil Properties across the broader scale of the Eastern United States
Authors: Khadka Saaruj , Bardhan Sougata
Published: November 2024

Effective management of white oak stand density is essential for maintaining biodiversity and ecosystem functions. This study examines the relationship between the stand density of declining white oaks and soil characteristics. Multicycle Forest Inventory data were aggregated to identify white oak plots throughout the eastern U.S. Stand density was calculated across plot systems that utilized basal area metrics across various states. Key soil variables were analyzed to assess their influence on stand density. The regression analyses revealed that these soil textures, including soil clay loam, fine sandy loam, and loamy fine sand had a significant negative impact on the stand density of declining white oaks (p ≤ 0.05), while both high and low extremes of TAW were positively associated with stand density. These findings underscore the critical role of soil properties in influencing the stand density of declining white oak populations. Insights from this study can support forest managers in assessing white oak stand conditions on a regional scale. Future work should expand on soil variables, integrating biotic and abiotic factors for a comprehensive approach to white oak conservation across the eastern U.S.
Oxygenated Layer Coating for Enhancing the Healing Process of Non-Healing Wounds-Case Report
Authors: Miłek Tomasz , Grzeczkowicz Anna , Lipko Agata , Mesjasz Maria , Oklesiński Leszek , Kwiatkowska Angelika , Strawski Marcin , Drabik Monika , Granicka Ludomira H.
Published: November 2024

The ever-increasing problem of chronic, non-healing wound treatment is a challenge in contemporary medicine. The study aims to verify the effect of a designed dressing containing coating involving oxygenating factors on promoting wound healing in all healing phases in a single clinical case. The alginate-based coating, which incorporates the oxygenating factor, was produced. The obtained surface physicochemical features were examined using FTIR and AFM microscopy. The bandage support was modified with elaborated coating and applied to the patients who suffered from chronic wounds (treated with non-modified commercially available bandage) and required treatment at least 3 months before starting the study. During bandage application, the chosen characteristics of the wound healing process were examined. Histological evaluation of granulation tissue confirmed the presence of fibroblasts, hemorrhage, and lymphocytes during the second week of treatment. Moreover, epithelization tissue in the third week of treatment exhibited the presence of keratinocytes. The 100% wound reduction was observed between 3-4 weeks of treatment with modified dressing. The applied coating, which provides a smooth surface of contact with the wound, inducing the remodeling phase in up to 4 weeks of treatment, can be recommended to be developed for hard-to-heal wound treatment.
Antibacterial and Antioxidant Efficacy of ZnO and Ag-Doped ZnO Nanoparticles Synthesized Using Artemisia absinthium Leaf Extract: A Comparative Study
Authors: Al-Yusufy Fatima Ahmed , Alharbi Fawzeeh Nayif , Abaker Zulfa Mohamed , Makawi Suzan Zein Alabdeen , Hussein Tasneem Ibrahim , Alhamzi Ebtesam Hassan Lutf
Published: November 2024

An eco-friendly plant-mediated approach was employed for the synthesis of green zinc oxide nanoparticles (ZnO NPs) and silver-doped zinc oxide nanoparticles (Ag-doped ZnO NPs), using Artemisia Absinthium leaf extract as a reducing and capping agent. Pure ZnO NPs were also synthesized without the leaf extract, and a comparative study between them was conducted. The nanoparticles (NPs) were characterized using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), morphological scanning electron microscopy/energy dispersive spectrum (SEM/EDX), and surface area (BET) analysis, and antioxidant and antibacterial activity measurements were conducted. The FTIR analysis showed the absorption peak of the Zn–O bond between 400 and 450 cm−1. The XRD analysis revealed that the ZnO NPs had a hexagonal wurtzite structure with a decrease in particle size from 36.32 to 27.40 to 25.13 nm, and an increase in the BET from 4.003 to 6.032 to 12.151 m2/g for the pure, green, and Ag-doped ZnO NPs, respectively. The field emission scanning electron microscopy (FESEM) imaging revealed the presence of the ZnO NPs. The EDX results showed the zinc and oxygen composition exhibited strong energy signals of 71.28% and 18.12% for zinc and oxygen, respectively. The various characterization techniques used confirmed the formation of the ZnO NPs. The free radical scavenging activities (RSِA%) measured using the 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH) assay at different concentrations and times for the pure, green, and Ag-doped ZnO NPs, and ascorbic acid were 25.50, 29.27, 28.56, and 56.7, respectively. The antibacterial activity of the synthesized samples was tested against three types of bacteria, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, and Pseudomonas aeruginosa ATCC 9027, at different levels (5, 10, 20, and 30 µL), using the hole plate diffusion method. The Ag/ZnO NPs showed more enhanced antibacterial activity than the green ZnO NPs, whereas the pure ZnO NPs showed no antibacterial activity under the same conditions. Comparatively, the antibacterial activity of the Ag-doped ZnO NPs against the test bacteria was found to be higher than that of a commercial gentamycin antibiotic. Ultimately, the present investigation has clearly shown that the differences in the ZnO NPs’ sizes and surface-area-to-volume ratios are responsible for their stronger antibacterial activity.
Analysis Study on the Incidence of Prematurity During the Year 2021
Authors: GOUDJIL Rayan
Published: November 2024

This study investigates the incidence of prematurity and its impact on maternal and neonatal health at Maternity Hospital, Ouargla, in 2021. Using a multidisciplinary approach, the research explores global and regional trends in prematurity, focusing on challenges and opportunities within Algeria and the broader African context. The analysis includes maternal health indicators and fetal biomarkers to identify risk factors and enable early predictive measures. Key findings discuss the physical characteristics of preterm infants, organ immaturity complications, and long-term outcomes for both mothers and newborns. Additionally, the study considers cultural and societal influences on the perception and management of prematurity and highlights advancements in prenatal and neonatal care, including early detection tools and neonatal resuscitation techniques. Emphasizing family-centered care and the transition to home-based support, the research reviews cutting-edge treatments such as pharmacological and non-pharmacological interventions, stem cell therapies, and respiratory support advancements. Socioeconomic and environmental impacts on prematurity rates are also assessed, underscoring the importance of maternal education and social support networks. The study concludes with evidence-based recommendations for healthcare providers, policymakers, and researchers to improve maternal and neonatal outcomes and reduce prematurity rates.
Immunohistochemical Diagnostic value of Calretinin in Hirschprung Disease
Authors: Azis Zainab , Cangara M. Husni , Zainuddin Andi Alfian , Wahid Syarifuddin , Mariana Nita , Miskad Upik A.
Published: November 2024

Introduction: Hirschsprung's disease (HD) is characterized by the absence of ganglion cells in Meissner's plexus and Auerbach's plexus which used to be assessed by histopathological examination using Hematoxylin and Eosin (H&E).  In some cases is difficult to assess ganglion cells, thus requiring additional examination in the form of calretinin immunohistochemistry to detect the presence of ganglion. Methods: The 59 samples of suspected HD  were analyzed by H&E staining followed by calretinin immunohistochemical staining. This study aimed to assess the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of calretinin in HD diagnostics. Results:  The immunohistochemistry of calretinin showed a good diagnostic value in detecting aganglionosis in patients with suspected HD with a sensitivity value = 97.7%; Specificity = 100%; Positive Presumptive Value (PPV) = 100%; Negative Presumptive Value (NPV) = 93.7%; Accuracy= 98.3%. Thus, calretinin immunohistochemistry can be relied upon as an additional method in the diagnosis of HD
The Dermatofibrosarcoma Protuberans In A 13-Year-Old: A Rare Case Of Soft Tissue Sarcoma Of The Skin
Authors: . Windy Rhomadani Putra , Iskandar Fery , Dumaria Ketty
Published: November 2024

Introduction and importance: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma that primarily affects middle-aged adults but can also occur in children. Despite its low metastatic potential, DFSP displays aggressive local behavior and a high rate of local recurrence. Diagnosis in children can be delayed due to confusion with other skin conditions.  This case report aims to discuss the case management of dermatofibrosarcoma protuberans in a 13 year old female.  Presentation of case:    A 13-year-old female patient presented with a progressively enlarging lump on the left eyelid, initially resembling small brown spots that coalesced over 7 months. Intermittent bleeding and pain were reported. Physical examination revealed a dark brown mass in the left frontotemporal region, with solid, non-fragile characteristics. Clinical diagnosis suggested a suspicious malignant skin tumor, confirmed as basal cell carcinoma. Treatment involved wide excision and flap reconstruction. Post-operative care included infusion, antibiotic injection, and pain management. The patient's prognosis was favorable, though functional impairment was possible. Follow-up revealed histopathological findings of pigmented dermatofibrosarcoma protuberans.  Discussion:    DFSP is a rare but significant malignancy that poses diagnostic challenges due to its varied clinical presentations and histopathological features. While primarily affecting young to middle-aged individuals, it can also manifest in pediatric populations. Diagnosis typically involves histopathological assessment, confirming characteristic spindle cell proliferation with CD34 expression. Surgical excision remains the cornerstone of treatment, complemented by adjuvant therapies like imatinib mesylate or radiation in select cases. Regular surveillance, comprising frequent evaluations in the initial post-excision period followed by yearly monitoring, is imperative for detecting any recurrence or metastasis promptly. Conclusions:   The structured approach in DFSP ensures optimal patient management and outcomes.  Surgical management with Wide local excision (WLE) or Mohs micrographic surgery (MMS) is the gold standard in the treatment of DFSP.
Lumbal Disk Hernisinde Egzersiz ve Sağlıklı Beslenme Programının Fiziksel ve Fonksiyonel Düzey Üzerine Etkisi: Vaka Çalışması
Authors: Morkoç Birgül , Bilgin Sevil , Dülger Esra , Soylu Ruhi , Türkoğlu İnci , Melekoğlu Ebru
Published: November 2024

Amaç: Bu çalışma lumbal stabilizasyon egzersizleri ve sağlıklı beslenme programının lumbal disk hernisine bağlı bel ağrısı olan kişilerin fiziksel ve fonksiyonel düzeyleri üzerine etkisini incelemek amacıyla yapılmıştır.Gereç ve Yöntem: Çalışmaya lumbal disk hernisi tanısı konulan iki birey dahil edildi. Bir hastaya lumbal stabilizasyon egzersizleri (Olgu 1), diğer hastaya stabilizasyon egzersizlerine ek olarak diyetisyen kontrolünde sağlıklı beslenme programı (Olgu 2) verildi. Egzersizler 8 hafta, haftada 3 gün fizyoterapist gözetiminde yaptırıldı. Tedavi öncesi ve 8. haftada ağrı, Transversus Abdominus ve Multifidus kas kalınlığı, gövde ve alt ekstremite kas kuvveti, antropometrik ölçüm, fiziksel aktivite, enerji ve besin öğeleri ölçümleri yapıldı.Bulgular: 8 haftalık tedavi sonrasında her iki olguda da ağrıların azaldığı, kas kalınlığında belirgin değişiklik olmadığı, gövde ve alt ekstremite kas kuvvetinin arttığı, vücut ağırlıklarının ve yağ kütlesinin azaldığı görüldü. Olgu 2’de ise fiziksel aktivite düzeyinin belirgin arttığı, enerji ve besin alımının normale yaklaştığı görüldü.Sonuç: Bu çalışma egzersiz ve sağlıklı beslenme programının lumbal disk hernisinde bireylerin fiziksel ve fonksiyonel düzey üzerine etkisini inceleyen ilk çalışmadır. Bel ağrılı kişilerin egzersiz ile birlikte sağlıklı beslenme programlarına yönlendirilmesinin fiziksel ve fonksiyonel düzey üzerine olumlu etki sağlayacağını düşünmekteyiz.
Üniversite Öğrencilerinde Temporomandibular Eklem Disfonksiyonu Prevalansının Araştırılması
Authors: Kaynak Besime Ahu , Taş Serkan , Ünlüer Nezehat Özgül , Yaşar Ümit , Erdoğanoğlu Yıldız
Published: November 2024

Amaç: Bu çalışmanın
amacı, üniversite öğrencilerinde
temporomandibular eklem disfonksiyonu (TMED) prevalansının araştırılmasıdır. Gereç ve Yöntem: Bu çalışma, 18-25 yaş
aralığında (20,5±1,5 yıl) 1104 kadın ve 334 erkek olmak üzere 1438 üniversite
öğrencisinin katılımıyla gerçekleşti. Çalışmaya katılan bireylerde TMED varlığı,
Fonseca Anamnestik Anketi kullanılarak değerlendirildi. Fonseca Anamnestik
Anketi 10 sorudan oluşmaktadır. Katılımcıdan her soruya ‘Evet’ (10 puan),
‘Hayır’ (0 puan) ve ‘Bazen’ (5 puan) olmak üzere cevap vermesi istenir. Anket
sonucunda elde edilen skora göre bireyler TMED yok (0-15 puan), hafif TMED’li
(20-40 puan), orta şiddette TMED’li (45-65 puan) ve şiddetli TMED’li (70-100)
olarak sınıflandırıldı. Bulgular: Değerlendirilen
1438 bireyden 547’sinde (%38) TMED olmadığı bulunurken, bireylerin 891’inde
(%62) TMED olduğu tespit edildi. TMED’li bireylerde TMED şiddeti
incelendiğinde, TMED tespit edilen 891 bireyden 664’ünde (%46,2) hafif şiddette
TMED, 180’ında orta şiddette TMED (%12,5) ve 47’sinde (%3,3) şiddetli TMED
olduğu bulundu. Değerlendirilen 1104 kadın bireyden 730’unda (%66,1) TMED
tespit edilirken, 374 kadın bireyde (%33,9) TMED olmadığı bulundu.
Değerlendirilen 334 erkek bireyden 173’ünde (%51,3) TMED yok iken, 161 erkek
bireyde (%48,7)  TMED olduğu bulundu.

Sonuç: Elde edilen sonuçlar üniversite öğrencilerinde TMED
prevalasının %62 olduğunu göstermektedir. Ayrıca, TMED’li bireylerin önemli bir
kısmının hafif TMED’li bireylerden oluştuğu tespit edildi. Kadınlarda TMED
prevalansının ve şiddetinin erkeklere göre daha fazla olduğu bulundu.
Genç Bireylerde Kor Kasları Kuvvetinin ve Enduransının Fonksiyonel Parametrelerle İlişkisinin İncelenmesi
Authors: Yumuşak Şafak , Büyükturan Buket , Karartı Caner , Büyükturan Öznur
Published: November 2024

Amaç: Kor bölgesindeki kasların kuvvetinin ve enduransının düşük olması, omurganın pasif yapıları üzerinde aşırı bir fizyolojik strese neden olmaktadır. Bu durum vücudun diğer yapıları boyunca ağrı oluşturabilmekte ve fonksiyonel performansı azaltabilmektedir. Bu çalışmanın hipotezi genç bireylerde kor kasları kuvvetinin ve enduransının fonksiyonel parametrelerle ilişkisinin incelenmesidir.Gereç ve Yöntem: Gövde kas kuvveti ve enduransının fonksiyonel parametrelerle ilişkisinin incelenmesi amacıyla çalışmaya yaş ortalaması 21,04±1,691 yıl olan 123 sağlıklı genç birey dahil edilmiştir. Çalışmada bireylerin demografik bilgileri kaydedilmiştir. Ayrıca kor kaslarının kuvvet değerlendirmesi modifiye push-up testi, sit-up testlerini; endurans değerlendirmesi lateral köprü testi, Sorenson testi ve gövde fleksörleri endurans testlerini içermektedir. Fonksiyonel parametreleri ise dikey sıçrama testi, bilateral çömelme (squat) testi, basamak inme testi ve tek bacak üzerinde öne zıplama testi ile değerlendirilmiştir. Bulgular: İstatiksel analiz sonucunda kor kuvvet testlerinden modifiye push-up testinin fonksiyonel performans testleri ile pozitif yönde anlamlı olarak ilişkili olduğu görülürken (r=0,188-0,50, p<0,05), kor kuvvet testlerinden sit-up testi ile fonksiyonel performans testlerinin korelasyon içerisinde olmadığı tespit edilmiştir (p>0,05). Kor endurans testleri ile fonksiyonel performans testlerinden dikey sıçrama testi, bilateral çömelme (squat) testi, basamak inme testlerinin pozitif yönde anlamlı olarak ilişkili olduğu görülmüştür (r=0,166-0,385, p<0,05). Sonuç: Çalışmanın sonucunda kor kaslarının kuvvet ve enduransı ile performansı inceleyen fonksiyonel parametreler arasında zayıf düzeyde anlamlı bir ilişki bulunmuştur. Fonksiyonel parametrelerin artırılmasında kor kaslarının kuvvet ve enduransına yönelik egzersizlerin göz önüne alınması gerektiğini düşünmekteyiz.
Otizm Spektrum Bozukluğu Olan Çocuklarda Postüral Kontrol, Denge ve İnce Motor Becerilerin İncelenmesi
Authors: Tunç Ünzile , Erdoğanoğlu Yıldız , Bahadır Ağce Zeynep
Published: November 2024

Amaç: Bu çalışmanın amacı, Otizm spektrum bozukluğu (OSB) tanılı çocuklarda, postüral kontrol, denge ve ince motor becerileri incelemekti. Gereç ve yöntem: Çalışmaya, 5-17 yaş aralığında, OSB’li 20 çocuk ve 20 sağlıklı çocuk dahil edildi. Çocukların demografik bilgileri alındıktan sonra, postüral kontrol seviyeleri Oturmada Postüral Kontrol Ölçeği (SPCM) ile, denge seviyeleri tek ayak denge testi ve topuk-parmak duruşu testi ile, ince motor becerileri Jebsen Taylor El Fonksiyon Testi ve 9 Delikli Peg Testi ile değerlendirildi.Bulgular: OSB’li çocuklar ve sağlıklı kontrol grubu arasında postüral kontrol, denge ve ince motor beceri değerleri arasında anlamlı fark bulundu (p<0,05). OSB’li çocukların postüral kontrol, denge ve ince motor becerilerde daha düşük seviyede oldukları görüldü. OSB’li çocukların postüral kontrol, denge ve ince motor becerileri arasında anlamlı ilişki bulunmadı (p>0,05).Sonuç: Bu çalışma sonucunda, OSB’li çocukların postüral kontrol, denge ve ince motor becerilerde yaşıtlarına kıyasla daha başarısız oldukları görüldü.
Erken Yıllarda İki Dilde Eğitim: Öğretmenlerin Bakış Açısıyla Etki ve Sonuçların İncelenmesi
Authors: Tercan Hülya , Tercan Ceren
Published: November 2024

Amaç İki dilde eğitim, yaklaşık 50 yılı aşkın bir süredir birçok ülkede eğitimsel bir seçenek olarak uygulanmaktadır. Literatür incelendiğinde alanda yapılan çalışmaların genellikle derleme özellikte oldukları dikkat çekmektedir. Son yıllarda ülkemizde de giderek yaygınlaşan iki dilde okul öncesi eğitim ile ilgili planlanan bu çalışmanın amacı, erken yıllarda iki dilde eğitim alan 2-6 yaş aralığındaki çocukların iki dilli sürece adaptasyonu, geçirdikleri aşamalar ve verilen tepkilerin öğretmenlerinin gözünden incelenmesidir. Gereç ve Yöntem: Araştırmada uygun veriler elde edilebilmek için araştırma tekniklerinden nitel teknik kullanılıştır. Bu kapsamda Ankara ilinde iki dilde eğitim veren bir okul öncesi eğitim kurumundaki okul öncesi öğretmenleri ve İngilizce öğretmenleri ile yarı yapılandırılmış bireysel görüşmeler yapılmıştır. Verilerin analizinde betimsel analiz tekniği kullanılmıştır. Bulgular -  Sonuç: Bu araştırmanın sonucunda, öğretmenlerin cevaplarından elde edilen bulgular çocukların genel gelişimsel özellikleri ve iki dilli eğitim sürecine etkisi, iki dilli eğitime uyum süreci, iki dilli eğitimin çocuklara etkileri, iki dilli eğitim sürecinde aile tepkileri, iki dilli eğitim ile ilgili öneriler ana temaları ile ilişkilendirilmiş, bulgular direk alıntılar şeklinde sunulmuştur. Bu çalışmanın sonuçlarının, bu alanda çalışan uzmanlara, ailelere ve iki dilde eğitim alan çocuklara olumlu çıktıları olacağı düşünülmektedir.