bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Algal Indices to Assess the Ecological Condition of the Aras River, Northwestern Iran
Authors: Parikhani Fatemeh , Atazadeh Ehsan , Razeghi Jafar , Mosaferi Mohammad , Kulikovskiy Maxim
Published: September 2023

This work is the first in a series, and its purpose is the comprehensive assessment of the ecological state of the Aras River using biological indicators of water quality by diatoms based on species’ ecological preferences, pollution indices, statistics, and ecological mapping. Samples of diatoms and soft algae and measurements of water quality were analyzed at sixteen sampling sites (between 2020 and 2022) along the Aras River. The impact of anthropological activity on the river was monitored concerning water quality, river health, and ecosystem function. The physical and chemical characteristics of the water were measured. The biological properties of the algal periphyton communities, including species composition, were also measured. Based on the studies conducted in this research, 280 species were identified. The most prosperous species were Diatoma vulgaris, Amphora ovalis, Cocconeis placentula, Rhoicosphenia abbre-viatae, Cymbella helvetica, Brevisira arentii, Navicula tripunctata, Nitzschia linearis, Microcystis botrys, Microcystis aeruginosa, Pseudanabaena limnetica, Scenedesmus obliquus, and Pleurosira laevis (a pollution-resistant and salinity-resistant species first found in aquatic habitats in the Aras River). As a result, the empirical data and algal indices showed the river’s lower reaches to be in poor condition. Exploration of the algal assemblage and water chemistry data using computationally unconstrained ordination techniques such as principal component analysis (PCA) and canonical correspondence analysis (CCA) indicated two strong gradients in the data sets. The results support that water body classification is a function of water chemistry and biological and hydrological characteristics, as it is necessary to include pollutant effects on biota since the nature of the receiving waters influences the river’s water quality.
The Effects of Wave-Induced Stokes Drift and Mixing Induced by Nonbreaking Surface Waves on the Ocean in a Climate System Ocean Model
Authors: Fan Peng , Jin Jiangbo , Guo Run , Li Guixian , Zhou Guangqing
Published: September 2023

Oceanic general circulation models (OGCMs) are important tools used to investigate mechanisms for ocean climate variability and predict the ocean change in the future. However, in most current ocean models, the impact of sea surface waves as one of the most significant dynamic processes in the upper ocean is absent. In this study, the Stokes drift and the vertical mixing induced by nonbreaking surface waves derived from the wave model (WAVEWATCH III) are incorporated into a Climate System Ocean Model, and their effects on an ocean climate simulation are analyzed. Numerical experiments show that both physical processes can improve the simulation of sea surface temperature (SST) and mixed layer depth (MLD) in the Southern Hemisphere. The introduction of Stokes drift effectively reduces the subsurface warm bias in the equatorial tropics, which is caused by the weakening of vertical mixing in the equatorial region. The nonbreaking surface wave mainly reduces the temperature bias in the Southern Ocean by enhancing mixing in the upper ocean. For the MLD, the Stokes drift mainly improves the simulation of the winter MLD, and the nonbreaking surface wave improves the summer MLD. For MLD south of 40° S in summer, the introduction of nonbreaking surface waves resulted in a reduction of 11.86 m in MLD bias and 7.8 m in root mean square errors (RMSEs), respectively. For winter subtropical MLD in the Southern Hemisphere, considering the Stokes drift, the MLD bias and RMSEs were reduced by 2.49 and 5.39 m, respectively. Adding these two physical processes simultaneously provides the best simulation performance for the structure of the upper layer. The introduction of sea surface waves effectively modulates the vertical mixing of the upper ocean and then improves the simulation of the MLD. Thus, sea surface waves are very important for ocean simulation, so we will further couple a sea waves model in the Chinese Academy of Sciences Earth System Model (CAS-ESM) as part of their default model component.
A First Expression, Purification and Characterization of Endo-β-1,3-Glucanase from Penicillium expansum
Authors: Wang Kaili , Huai Siyu , Tan Zhuqing , Ngea Guillaume Legrand Ngolong , Godana Esa Abiso , Shi Jun , Yang Qiya , Zhang Xiaoyun , Zhao Lina , Zhang Hongyin
Published: September 2023

β-1,3-glucanase plays an important role in the biodegradation, reconstruction, and development of β-1,3-glucan. An endo-β-1,3-glucanase which was encoded by PeBgl1 was expressed, purified and characterized from Penicillium expansum for the first time. The PeBgl1 gene was amplified and transformed into the competent cells of E. coli Rosetta strain with the help of the pET-30a cloning vector. The recombinant protein PeBgl1 was expressed successfully at the induction conditions of 0.8 mmol/L IPTG at 16 °C for 16 h and then was purified by nickel ion affinity chromatography. The optimum reaction temperature of PeBgl1 was 55 °C and it had maximal activity at pH 6.0 according to the enzymatic analysis. Na2HPO4-NaH2PO4 buffer (pH 6.0) and NaCl have inhibitory and enhancing effects on the enzyme activities, respectively. SDS, TritonX-100 and some metal ions (Mg2+, Ca2+, Ba2+, Cu2+, and Zn2+) have an inhibitory effect on the enzyme activity. The results showed that PeBgl1 protein has good enzyme activity at 50–60 °C and at pH 5.0–9.0, and it is not a metal dependent enzyme, which makes it robust for storage and transportation, ultimately holding great promise in green biotechnology and biorefining.
Resistance of Mycorrhizal Cinnamomum camphora Seedlings to Salt Spray Depends on K+ and P Uptake
Authors: Xue Lin , Liu Peng , Wu Aiping , Dong Lijia , Wu Qiqian , Zhao Mingshui , Liu Hua , Li Yan , Zhang Naili , Wang Yanhong
Published: September 2023

Salt spray is a major environmental issue in coastal areas. Cinnamomum camphora is an economically important tree species that grows in the coastal areas of southern China. Arbuscular mycorrhizal fungi (AMF) can alleviate the detrimental effects of abiotic stress on host plants. However, the mechanism by which AMF mitigates the adverse effects of salt spray on C. camphora remains unclear. A pot experiment was conducted in a greenhouse, where C. camphora seedlings were exposed to four AMF regimes (inoculation with sterilized fungi, with Glomus tortuosum, Funneliformis mosseae, either alone or in combination) and three salt spray regimes (applied with distilled water, 7, and 14 mg NaCl cm−2) in order to investigate the influence on root functional traits and plant growth. The results showed that higher salt spray significantly decreased the K+ uptake, K+/Na+ ratio, N/P ratio, total dry weight, and salinity tolerance of non-mycorrhizal plants by 37.9%, 71%, 27.4%, 12.7%, and 221.3%, respectively, when compared with control plants grown under non-salinity conditions. Mycorrhizal inoculation, particularly with a combination of G. tortuosum and F. mosseae, greatly improved the P uptake, total dry weight, and salinity tolerance of plants grown under higher salt spray conditions by 51.0%, 36.7%, and 130.9%, respectively, when compared with their counterparts. The results show that AMF can alleviate the detrimental effects of salt spray on C. camphora seedlings. Moreover, an enhanced uptake of K+ and P accounted for the resistance of the plants to salt spray. Therefore, pre-inoculation with a combination of G. tortuosum and F. mosseae to improve nutrient acquisition is a potential method of protecting C. camphora plants against salt spray stress in coastal areas.
Research Progress of Piriformospora indica in Improving Plant Growth and Stress Resistance to Plant
Authors: Li Liang , Feng Yu , Qi Fuyan , Hao Ruiying
Published: September 2023

Piriformospora indica (Serendipita indica), a mycorrhizal fungus, has garnered significant attention in recent decades owing to its distinctive capacity to stimulate plant growth and augment plant resilience against environmental stressors. As an axenically cultivable fungus, P. indica exhibits a remarkable ability to colonize varieties of plants and promote symbiotic processes by directly influencing nutrient acquisition and hormone metabolism. The interaction of plant and P. indica raises hormone production including ethylene (ET), jasmonic acid (JA), gibberellin (GA), salicylic acid (SA), and abscisic acid (ABA), which also promotes root proliferation, facilitating improved nutrient acquisition, and subsequently leading to enhanced plant growth and productivity. Additionally, the plant defense system was employed by P. indica colonization and the defense genes associated with oxidation resistance were activated subsequently. This fungus-mediated defense response elicits an elevation in the enzyme activity of antioxidant enzymes, including superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), and, finally, bolsters plant tolerance. Furthermore, P. indica colonization can initiate local and systemic immune responses against fungal and viral plant diseases through signal transduction mechanisms and RNA interference by regulating defense gene expression and sRNA secretion. Consequently, P. indica can serve diverse roles such as plant promoter, biofertilizer, bioprotectant, bioregulator, and bioactivator. A comprehensive review of recent literature will facilitate the elucidation of the mechanistic foundations underlying P. indica–crop interactions. Such discussions will significantly contribute to an in-depth comprehension of the interaction mechanisms, potential applications, and the consequential effects of P. indica on crop protection, enhancement, and sustainable agricultural practices.
Initial Experience of Articulating Laparoscopic Instruments for Benign Gynecologic Disease: A Single-Arm Multicenter Prospective Study (Korean Gynecologic Oncology Group 4002)
Authors: Noh Joseph J. , Kim Kidong , Kim Tae-Joong , Kim Taehun , Lee Keun Ho , Hwang Jong Ha , Hong Dae Gy , Kim Min Kyu , Lee Banghyun , Chang Ha Kyun , Chun Kyoung Chul
Published: September 2023

Laparoscopic surgery has evolved with technological advances in many aspects and increasing demand for its benefits in cosmetics, fast recovery, reduced complication rates and pain. However, it still possesses drawbacks such as limited surgical movement due to the nature of rigid laparoscopic instruments. In order to overcome such limitations, several laparoscopic jointed instruments have been developed. In this prospective multicenter, single-arm cohort study, we investigated the short-term safety and feasibility of the new articulating laparoscopic instruments in benign gynecologic surgery. A total of 113 patients who were diagnosed with benign gynecologic adnexal diseases underwent laparoscopic surgery with articulating laparoscopic instruments. Surgical outcomes, including intra/postoperative complication rates, operation time and estimated blood loss, as well as surgeon’s subjective evaluation of the usage of the instruments, were evaluated. The results demonstrated that the articulating laparoscopic instruments had comparable usability and produced similar surgical outcomes to conventional laparoscopic surgery. The objective parameters, such as the operative time and complication rates, as well as the subjective parameters, such as the surgeon’s own evaluation of the surgical instruments’ usability, demonstrated potential benefits of the instruments in benign gynecological diseases. Overall, the study demonstrated that the use of this novel articulating device is feasible in gynecologic laparoscopic surgery.
Inflammatory Biomarkers and Blood Physical Property Transformations Following On-Pump Coronary Artery Bypass Graft Surgery
Authors: Hsu Po-Shun , Chen Jia-Lin , Sung Shih-Ying , Tsai Yi-Ting , Lin Chih-Yuan , Wu Yi-Fan , Tsai Chien-Sung
Published: September 2023

Objective: This study aimed to compare the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery, as factors such as hypothermia, hemodilution, transfusion, and other variables affect blood viscosity and inflammation during the procedure. Methods: A total of 25 patients who underwent CABG surgery were enrolled in this study. Whole blood was collected just before the CABG (D0), 2 days after surgery (D2), and 5 days after surgery (D5). The plasma viscosity (PV) and whole blood viscosity (WBV) were measured at shear rates ranging from 0.1 to 1000 s−1 using a rheometer, and the mean values were compared. Inflammatory markers were also assessed and analyzed in relation to the hemorheological changes. Results: Compared with the baseline values, the PV significantly increased after 5 days. WBV showed a significant increase on day 2 and after 5 days. The WBV and fibrinogen were significantly correlated on day 2 and day 5 but not before surgery. Inflammatory markers such as CRP, WBC, platelets, and fibrinogen also demonstrated notable changes in relation to the hemorheological alterations. Conclusions: This study highlights the crucial finding that hyperviscosity, characterized by elevated PV and WBV, persists for almost one week after on-pump CABG surgery. Understanding the interplay between inflammation and hemorheological properties during the postoperative period is crucial for optimizing patient care. Future research should focus on exploring the underlying mechanisms and potential therapeutic interventions to mitigate the impact of inflammation on blood viscosity and improve patient outcomes following CABG surgery.
The Current Situation of Anaesthesia for Hysteroscopy in Mainland China: A National Survey
Authors: Huang Lili , Yu Qing , Zhu Ziyu , Huang Ping , Ding Xibing , Ma Xiaowen , Chen Yuwen , Su Diansan
Published: September 2023

Purpose: The need for anaesthesia or analgesia for performing hysteroscopy remains debatable. This study aimed to conduct an overview of the situation of anaesthesia for hysteroscopy in mainland China. Methods: Two questionnaires were separately designed for anaesthesiologists and gynaecologists and distributed to every medical institution that performed hysteroscopic procedures on patients with infertility in mainland China. Electronic questionnaires were distributed via WeChat, and data on anaesthesia regimen, monitoring parameters, procedure number, and other information were collected. Results: Reproductive technology is conducted by 536 institutions in mainland China. The survey received 491 responses from anaesthetists (91.6%) and 436 from gynaecologists (81.3%). In 2021, 552,225 hysteroscopies were conducted in 268 medical centres. The average percentage of hysteroscopy under anaesthesia is 63.8% in 2021, wherein 47.3% of institutions have an anaesthesia percentage of >75%. Propofol and opioid analgesics, such as fentanyl and sufentanil, were the most commonly used intravenous anaesthetics. All sedations were performed by anaesthesiologists. Monitoring parameters included pulse oxygen saturation (98.9%), electrocardiogram (91.6%) and noninvasive blood pressure (91.3%). An anaesthesiologist-to-operating room ratio of <1 was observed in 31.3% of medical institutions. Surprisingly, 52.4% of medical institutions performing hysteroscopy had no postanaesthesia care unit (PACU). Most institutions with PACU were equipped with independent oxygen sources, suction and monitors. Both rigid and flexible hysteroscopes (rigid hysteroscope, 45.1%; flexible hysteroscope, 4.5%; both types, 50.4%) were used, and the hysteroscopic diameter was ≤5 mm in 60.3% of medical centres. Conclusions: China performs a large number of hysteroscopies, and sedation is the most frequently used anesthesia regimen. However, issues such as inadequate emergency support devices, insufficient personnel and weak resuscitation management after anaesthesia, have been observed.
Improvements in Treatment Adherence after Family Psychoeducation in Patients Affected by Psychosis: Preliminary Findings
Authors: Iuso Salvatore , Severo Melania , Trotta Nicoletta , Ventriglio Antonio , Fiore Pietro , Bellomo Antonello , Petito Annamaria
Published: September 2023

(1) Background: Family psychoeducation is a well-recognized intervention which aims to improve the outcomes of illness in patients affected by psychosis. It has benefits in treatment adherence and leads to a reduction in relapses, higher levels of patient insight, and lower levels of stress within the family and among caregivers. (2) Methods: Eight patients and their families were recruited and randomly assigned to a Falloon-based family psychoeducation (FPP) intervention, and nine patients and their families were randomized to a Gestalt-based family intervention (GT). We compared the outcomes of these two treatment groups at a baseline assessment (T0), at the end of the programs (T1), and 6 and 12 months after the end of the programs (T2 and T3). The assessments included examinations of cognition (The Mini-Mental State Examination (MMSE) and The Five Point Test (5 Point)), the psychopathology and severity of illness (The Brief Psychiatric Rating Scale (BPRS), The Positive and Negative Syndrome Scale (PANSS), and The Clinical Global Impression Scale (CGI)), expressed emotion in families (Expressed Emotionality (Family Questionnaire-EE)), patient quality of life (The World Health Organization Quality of Life—BREF (WHOQOL-B)), social functioning (The Personal Social Performance (SPS)), aggression (Modified Overt Aggression Scale (MOAS)), and treatment adherence (The Brief Medication Adherence Report Scale (BMARS)). The primary aim was to test whether the FFP vs. GT program was more effective in improving treatment adherence over time. (3) Results: treatment adherence improved much more in the FFP group over time at any follow-up: +43.1% at T1, +24.0% at T2, and +41.6% at T3. Other characteristics, including psychopathology and the clinical stability of the subject, did not change over time. (4) Discussion: Family psychoeducation based on the Falloon program was effective at improving treatment adherence and contributed to avoiding relapses in the long term. Further studies on larger samples should be conducted to confirm this evidence, and similar psychoeducational programs should be routinely promoted in the clinical setting.
On the Dynamic Relationship between Household Debt and Income Inequality in South Africa
Authors: Zhou Sheunesu , Niyitegeka Olivier
Published: September 2023

This paper analyses the relationship between household debt and income inequality in South Africa for the period 1980–2021. We use two measures of inequality and estimate a vector error correction model (VECM) which includes household debt, inequality, and other macroeconomic variables. To test the robustness of our results, single equation models are used, which estimate household debt as a function of inequality and macroeconomic factors. We employ two measures of inequality, namely Gini coefficient and ratio of top and bottom income earners’ proportion of income. Furthermore, we use both household debt as a percentage of disposable income and household debt service costs as dependent variables in single equation regressions. The study finds a negative and significant relationship between household debt and income inequality in the long run, which contradicts the Rajan hypothesis in the South African case. Rather, we find that inequality in South Africa creates a bias in debt allocation towards high-income earners, whose incomes can easily absorb the extra debt (reduced ratio of debt to disposable income). There are therefore no socio-equity considerations in South African credit markets. We find growth in gross domestic product (GDP) per capita also has a moderating effect on the relationship between household debt and income inequality. High GDP per capita growth in the presence of high inequality reduces the impact of inequality on household debt and vice-versa. All other control variables take expected signs. These results are robust to changes in the inequality or household debt measures.
Interconnectedness of Cryptocurrency Uncertainty Indices with Returns and Volatility in Financial Assets during COVID-19
Authors: Asiri Awad , Alnemer Mohammed , Bhatti M. Ishaq
Published: September 2023

This paper investigates the dynamic relationship between cryptocurrency uncertainty indices and the movements in returns and volatility across spectrum of financial assets, comprising cryptocurrencies, precious metals, green bonds, and soft commodities. It employs a Time-Varying Parameter Vector Autoregressive (TVP-VAR) connectedness approach; the analysis covers both the entire sample period spanning August 2015 to 31 December 2021 and the distinct phase of COVID-19 pandemic. The findings of the study reveal the interconnectedness of returns within these asset classes during the COVID-19 pandemic. In this context, cryptocurrency uncertainty indices emerge as influential transmitters of shocks to other financial asset categories and it significantly escalates throughout the crisis period. Additionally, the outcomes of the study imply that during times of heightened uncertainty, exemplified by events such as the COVID-19 pandemic, the feasibility of portfolio diversification for investors might be constrained. Consequently, the amplified linkages between financial assets through both forward and backward connections could potentially compromise financial stability. This research sheds light on the impact of cryptocurrency uncertainty on the broader financial market, particularly during periods of crisis. The findings have implications for investors and policymakers, emphasizing the need for a comprehensive understanding of the interconnectedness of financial assets and the potential risks associated with increased interdependence. By recognizing these dynamics, stakeholders can make informed decisions to enhance financial stability and manage portfolio risk effectively.
Tax Planning on New Tobacco Risk-Reduced Products in Europe: Assessment and Implications for Public Policies
Authors: Pinto Hernández Fernando , Delgado Rodríguez María Jesús
Published: September 2023

Taxes on the consumption of certain products have played a key role in public revenue analysis in European countries. This work assesses the differences in tax planning for new non-combustion products across some European territories. Through theoretical analysis, the paper has three distinct aspects. Firstly, we show the taxpayer profile in different countries. Secondly, the study analyzes the risks for the health system and the individual. Thirdly, the design of the national tobacco tax is based on previous experience and planning in Europe. This paper concludes with a case study for different countries: (1) Spain “vapers” and “smokers”, where the analysis is based on micro-data from the European Health Interview Survey 2020. (2) Sweden, with the analysis of snus, shows it as a practice on how to reach economic savings while decreasing economic costs thanks to the nudging of consumers towards better products. The results show taxation and, especially, land taxation should consider differences in planning in the case of new products, such as non-combustion products, given the user per capita income and the potential lower health risks involved.
Design Characteristics, Visual Qualities, and Walking Behavior in an Urban Park Setting
Authors: Paydar Mohammad , Kamani Fard Asal , Gárate Navarrete Verónica
Published: September 2023

The design characteristics of urban parks’ pathways are important in facilitating leisure walking and maintaining the minimum rate of physical activity, thus improving public health. This study examined and explored the relationships between design characteristics as well as certain visual qualities of Cautin Park, the biggest urban park in the Araucanian Region of Chile, and the tendency for walking as well as walking behavior. A mix of quantitative and qualitative methods was used to examine the objectives. Several design attributes were found to be related to the tendency for walking and the walking behavior in this urban park, including greater pathway width, more vegetation, tranquility along the pathways, and more comfortable pathway environments for pets. Additionally, these correlations were assessed based on gender and age, and it was found that adolescents showed the greatest difference from other groups. For instance, adolescents walk significantly more along pathways with more connectivity to activity zones. Among the visual qualities, only legibility shows a significant correlation with the number of all types of pedestrians, as well as subgroups of adolescents, adult men, and adult women. These results were reviewed, and their implications were discussed. Urban planners and designers could apply these findings when designing future urban parks in this context.
Are Turkish Non-Case-Marked Objects with and without bir Interpreted and Acquired Differently?
Authors: Ketrez F. Nihan
Published: September 2023

Whether non-case-marked objects with and without the numeral bir in Turkish have the same structural properties or not has been a topic of discussion for decades. This study aims to contribute to this discussion with experimental data that compares the comprehension of these object types along with their accusative-marked indefinite counterparts in terms of their scope with respect to negation by four-, five-, and six-year-old children as well as adults. The results suggest that both non-case-marked objects with and without bir contrast with accusative-marked indefinite objects and have a narrow scope with respect to negation in adults’ speech. However, bir can still have a main effect on the interpretation of the objects, just like the accusative case, and unlike non-case-marked objects without bir, objects with bir may scope over negation. Children treat all object types alike at age four and distinguish objects with and without bir at age five. These findings are compatible with an account that assumes different structures for two types of non-case-marked objects.
Optical EUS Activation to Relax Sensitized Micturition Response
Authors: Hong Jin-Ki , Moon Hyuk-June , Shin Hyun-Joon
Published: September 2023

This study aims to activate the external urethral sphincter (EUS), which plays a critical role in micturition control, through optogenetics and to determine its potential contribution to the stabilization of sensitized micturition activity. The viral vector (AAV2/8-CMV-hChR2(H134R)-EGFP) is utilized to introduce light-gated ion channels (hChR2/H134R) into the EUS of wild-type C57BL/6 mice. Following the induction of sensitized micturition activity using weak acetic acid (0.1%) in anesthetized mice, optical stimulation of the EUS muscle tissue expressing channel rhodopsin is performed using a 473 nm laser light delivered through optical fibers, and the resulting changes in muscle activation and micturition activity are examined. Through EMG (electromyography) measurements, it is confirmed that optical stimulation electrically activates the EUS muscle in mice. Analysis of micturition activity using cystometry reveals a 70.58% decrease in the micturition period and a 70.27% decrease in the voiding volume due to sensitized voiding. However, with optical stimulation, the micturition period recovers to 101.49%, and the voiding volume recovered to 100.22%. Stimulation of the EUS using optogenetics can alleviate sensitized micturition activity and holds potential for application in conjunction with other micturition control methods.
Occupational Exposure during Pregnancy and Effects on Newborns: A Nested Case-Control Study
Authors: Donzelli Gabriele , Marcos-Puig Beatriz , Peraita-Costa Isabel , Llopis-Morales Juan , Morales-Suarez-Varela María
Published: September 2023

Background: The protection of pregnant workers should be based on evidence regarding the risks to reproductive health from exposure to specific work environments and conditions. The objective of this study was to identify the effects on mothers and newborns resulting from environmental exposure to various occupational risks. Methods: The study cohort was composed of 399 women admitted to the Obstetrics/Postpartum ward at Hospital La Fe in Valencia, Spain. Face-to-face interviews were conducted to establish associations between workplace exposure during pregnancy and its effects on maternal and newborn health. Sex, anthropometric characteristics, and blood gas analysis in arterial and venous umbilical cord blood at delivery were collected. Results: A total of 138 women were exposed to biological and/or chemical risks, 122 to physical risks, and 139 at no risk of exposure. In the group with chemical and/or biological risks, the frequency of women who resorted to in vitro fertilization to achieve the studied pregnancy is less than half of the group exposed to physical risks, with statistically significant differences (p = 0.047). The mean values for the arterial analysis in both exposure groups were within average values, with similar pH values between them, but the mean values of PCO2 and PO2 were lower in the group of neonates of mothers exposed to physical risks, with a significant difference for arterial PO2 (p = 0.027). Conclusion: Our analysis contributes evidence for planning and prioritizing preventive actions to protect women’s reproductive health. The results suggest the continuation of a future project that would consider more factors and potentially increase the sample size.
Chronic Hepatitis C Virus Infection: An Ongoing Challenge in Screening and Treatment
Authors: Tsai Wei-Chu , Chiang Hsueh-Chien , Chiu Yen-Cheng , Chien Shih-Chieh , Cheng Pin-Nan , Chiu Hung-Chih
Published: September 2023

With the advent of direct-acting antiviral agents (DAA) in the recent few years, hepatitis C virus (HCV) infection has become a curable infectious disease. Successful clearance of HCV could lead to improvement of both hepatic and extrahepatic outcomes, such as complications of cirrhosis, hepatocellular carcinoma, cardiovascular diseases, and incident diabetes. However, challenges persist in reaching the HCV elimination goals of the World Health Organization by 2030. Among these challenges are identifying those already infected or undiagnosed subjects, re-linking to the care of known but untreated HCV-infected subjects, and developing strategies to enhance treatment rates and compliance in specific or high-risk populations. In addition, issues of post-DAA viral clearance, including avoiding or preventing reinfection in high-risk populations and surveillance of hepatocellular carcinoma, are important to consolidate the treatment’s short- and long-term efficacies. In the current DAA era, treatment is the most effective prevention strategy not only in its excellent efficacy and safety but also in preventing HCV spread. All of the surveillance or measures should center on DAA treatment in clinical practice.
Numerical Simulation of Uniaxial Compressive Strength and Failure Characteristics of Non-Uniform Water-Bearing Sandstone
Authors: Song Mingwei , Zhang Wenzhi , Zou Youfeng , Chen Junjie
Published: September 2023

As complex and heterogeneous materials, the mechanical properties of rocks are still in need of further investigation regarding the mechanisms of the effects of water. In engineering projects such as goaf foundation treatment and ecological restoration, it is particularly important to describe the fracturing process of non-uniform water-containing sandstone media. The study utilized the theory of continuum mechanics to adopt an elastoplastic strain-softening constitutive relationship and develop a numerical model for analyzing the uniaxial compressive strength and failure characteristics of non-uniform water-containing sandstone. The results indicate that, compared with the reference rock sample, the shorter the capillary path of water entering the rock sample’s internal pores or the larger the contact area with water, the shorter the time required for the rock sample to be saturated. Increasing the water content causes a rapid decline in the rock sample’s elastic modulus and intensifies its brittleness. Group D2 and D3 samples exhibited a decrease in average peak strength to 70.4% and 62.1%, respectively, along with a corresponding decrease in the elastic modulus to 90.78% and 76.55%, indicating significant strain softening. While the failure mode of the rock sample remains consistent across different water contents, the homogeneity of failure shows significant variation. Increasing volumetric water content raises the likelihood of interconnecting cracks between rock samples, resulting in a progressive decline in macroscopic mechanical properties such as peak strength, critical strain, and elastic modulus. This research is significant in advancing the theory and construction technology for ecological restoration in goaf areas.
Enhanced Release of Calcium Ions from Hydroxyapatite Nanoparticles with an Increase in Their Specific Surface Area
Authors: Szałaj Urszula , Chodara Agnieszka , Gierlotka Stanisław , Wojnarowicz Jacek , Łojkowski Witold
Published: September 2023

Synthetic calcium phosphates, e.g., hydroxyapatite (HAP) and tricalcium phosphate (TCP), are the most commonly used bone-graft materials due to their high chemical similarity to the natural hydroxyapatite—the inorganic component of bones. Calcium in the form of a free ion or bound complexes plays a key role in many biological functions, including bone regeneration. This paper explores the possibility of increasing the Ca2+-ion release from HAP nanoparticles (NPs) by reducing their size. Hydroxyapatite nanoparticles were obtained through microwave hydrothermal synthesis. Particles with a specific surface area ranging from 51 m2/g to 240 m2/g and with sizes of 39, 29, 19, 11, 10, and 9 nm were used in the experiment. The structure of the nanomaterial was also studied by means of helium pycnometry, X-ray diffraction (XRD), and transmission-electron microscopy (TEM). The calcium-ion release into phosphate-buffered saline (PBS) was studied. The highest release of Ca2+ ions, i.e., 18 mg/L, was observed in HAP with a specific surface area 240 m2/g and an average nanoparticle size of 9 nm. A significant increase in Ca2+-ion release was also observed with specific surface areas of 183 m2/g and above, and with nanoparticle sizes of 11 nm and below. No substantial size dependence was observed for the larger particle sizes.
Crystallinity and Oscillatory Shear Rheology of Polyethylene Blends
Authors: Nagy Dorottya , Weltsch Zoltán
Published: September 2023

Crystallinity and rheological behavior are significant for processing semi-crystalline polymers with fine mechanical properties. There is always an economical need to create a less expensive new material with better properties. Non-isothermal crystallization and oscillatory shear rheology of different branch-type polyethylene–polyethylene blends were investigated. Samples of high-density and low-density polyethylene (HDPE/LDPE) (20/80, 40/60, 60/40 and 80/20 weight ratios) and two types of high-density and linear low-density polyethylene (HDPE/LLDPE) (40/60 and 60/40 weight ratios) were prepared via extrusion. The materials were tested by differential scanning calorimetry (DSC) at several cooling rates (5, 10, 20, 30 and 40°/min) and by oscillation rheometry (ARES G2) at low angular frequency range to prove their miscibility or immiscibility. It was found that the one-peak melting endotherm of the 80–20% HDPE-LDPE blend could indicate miscibility in the solid phase, while the other HDPE-LDPE blends with two-peak curves are partially or not miscible. In contrast, all the HDPE-LLDPE blends indicate co-crystallization, but the 40–60% HDPE-LLDPE butylene blend is probably immiscible. It was revealed that complex viscosity decreases with angular frequency: linearly for HD-LD blends and not linearly for HD-LLDPE blends. The complex viscosity shows linear behavior with composition for HD-LLDPE blends, while there is a positive–negative deviation for HD-LD blends. In the liquid phase, according to rheological measurements, the HDPE-LDPE blends are not or partially miscible, while the HDPE-LLDPE blends are probably miscible.
Fabricating Inner Channels in Laser Additive Manufacturing Process via Thin-Plate-Preplacing Method
Authors: Jiao Junke , Sun Shengyuan , Xu Zifa , Wang Jiale , Sheng Liyuan , Gao Jicheng
Published: September 2023

This paper presents a hybrid manufacturing process for the preparation of complex cavity structure parts with high surface quality. Firstly, laser precision packaging technology is utilized to accurately connect a thin plate to a substrate with microchannel. Secondly, Direct Metal Laser-Sintering (DMLS) technology is utilized to completely shape the part. The morphology and microstructure of laser encapsulated specimens and DMLS molded parts were investigated. The results show that the thin plate and the substrate can form a good metallurgical bond. The lowest surface roughness of the DMLS molded parts was 1.18 μm. The perpendicularity between the top of the microchannel and the side wall was optimal when the laser power was 240 W. Consequently, the hybrid manufacturing process effectively solves the problems of poor surface quality and powder sticking of closed inner cavities. The method effectively eliminates the defects of adhesive powder in the inner cavity of the DMLS microchannel, improves the finish, and solves the problem that mechanical tools cannot be processed inside the microchannel, which lays the foundation for the research of DMLS high-quality microchannel process.
Tuning the Photophysical Properties of Acceptor–Donor–Acceptor Di-2-(2-oxindolin-3-ylidene) Malononitrile Materials via Extended π–Conjugation: A Joint Experimental and Theoretical Study
Authors: Ren Shiwei , Habibi Amirhossein , Ni Pingping , Zhang Yuexing , Yassar Abderrahim
Published: September 2023

Many optoelectronic applications require organic semiconductor (OSC) materials with high electron affinity. In this work, a series of novel acceptor–donor–acceptor (A–D–A) materials with low-lying LUMO energy levels were designed and characterized. In this strategy, two acceptor dyes, bis-isatin and di-2-(2-oxindolin-3-ylidene) malononitrile, were connected by various π–bridges (benzene ring, benzo[c][1,2,5]thiadiazole, monothiophene, trithiophene). We varied the length of the π–conjugation of the central core and the linkage position of the acceptor core (4- vs. 6-position of the phenyl ring) to investigate the effect on the optical and electrochemical properties of the materials. We performed density functional theory (DFT) and time-dependent DFT (TD–DFT) studies to gain insight into the dyes’ electronic properties by determining the energy levels. Our findings demonstrate that with increasing acceptor strength and π–conjugation length of the core, the wavelength of the longest absorption maximum as well as their respective extinction coefficients are enhanced, which results in band-gap reduction either by lowering the LUMO and/or raising the HOMO energy level of the molecules. The potential practical utility of these materials as electron-transport materials for perovskite solar cells (PSCs) has been demonstrated.
Application of Composts’ Biochar as Potential Sorbent to Reduce VOCs Emission during Kitchen Waste Storage
Authors: Rosik Joanna , Łyczko Jacek , Marzec Łukasz , Stegenta-Dąbrowska Sylwia
Published: September 2023

It is expected that due to the new European Union regulation focus on waste management, managing kitchen waste will become more important in the future, especially in households. Therefore, it is crucial to develop user-friendly and odour-free containers to store kitchen waste. The study aimed to test the effectiveness of composts’ biochar in reducing noxious odours and volatile organic compounds (VOCs) released during kitchen waste storage. Various amounts of compost biochar (0%, 1%, 5%, and 10%) were added to food waste samples and incubated for seven days at 20 °C. The released VOCs were analysed on days 1, 3, and 7 of the storage simulation process. The results indicated that adding 5–10% of composts’ biochar to kitchen waste significantly reduced the emissions in 70% of the detected VOCs compounds. Furthermore, composts’ biochar can be used to eliminate potential odour components and specific dangerous VOCs such as ethylbenzene, o-xylene, acetic acid, and naphthalene. A new composts’ biochar with a unique composition was particularly effective in reducing VOCs and could be an excellent solution for eliminating odours in kitchen waste containers.
Effects of NMDA Receptor Hypofunction on Inhibitory Control in a Two-Layer Neural Circuit Model
Authors: Ye Weijie , Chen Xiaoying
Published: September 2023

Inhibitory control plays an important role in controlling behaviors, and its impairment is a characteristic feature of schizophrenia. Such inhibitory control has been examined through the the stop-signal task, wherein participants are asked to suppress a planned movement when a stop signal appears. In this research, we constructed a two-layer spiking neural circuit model to study how N-methyl-D-aspartate receptor (NMDAR) hypofunction, a potential pathological mechanism in schizophrenia, impacts the inhibitory control ability in the stop-signal task. To find the possible NMDAR hypofunction effects in schizophrenia, all NMDA-mediated synapses in the model were set to be NMDAR hypofunction at different levels. Our findings revealed that the performances of the stop-signal task were close to the experimental results in schizophrenia when NMDAR hypofunction was present in the neurons of two populations that controlled the “go” process and the “stop” process of the stop-signal task, implying that the execution and inhibition of behaviors were both impaired in schizophrenia. Under a certain degree of NMDAR hypofunction, the circuit model is able to replicate the stop-signal task performances observed in individuals with schizophrenia. In addition, we have observed a predictable outcome indicating that NMDAR hypofunction can lower the saccadic threshold in the stop-signal task. These results provide a mechanical explanation for the impairment of inhibitory control in schizophrenia.
An Inverse Approach for Finding Graphs with a Failed Zero Forcing Number of k
Authors: Kaudan Chirag , Taylor Rachel , Narayan Darren A.
Published: September 2023

For a given a graph G, the zero forcing number of G, Z(G), is the smallest cardinality of any set S of vertices on which repeated applications of the forcing rule results in all vertices being included in S. The forcing rule is as follows: if a vertex v is in S, and exactly one neighbor u of v is not in S, then u is added to S in the next iteration. The failed zero forcing number of a graph was introduced by Fetcie, Jacob, and Saavedra and was defined as the cardinality of the largest set of vertices which fails to force all vertices in the graph. In 2021, Gomez et al. proved that there were exactly 15 graphs with a failed zero forcing number of two, but their proof was complicated, requiring the analysis of many graph families. We present an “inverse” approach where we start with a set of vertices S and then see which graphs have S as a maximum-sized failed zero forcing set. This results in not only a shorter proof but characterizes which graphs have a particular failed zero forcing set. In our proof, we characterize the graphs which have a failed zero forcing set S where |S|=2, meaning considering all simple graphs of order two as induced subgraphs. This approach also has greater potential for characterizing graphs where F(G)>2 since many general arguments on the structure of graphs are developed in this type of analysis and are applicable for failed zero forcing sets of any size.
Optimal Deep-Learning-Based Cyberattack Detection in a Blockchain-Assisted IoT Environment
Authors: Assiri Fatmah Y. , Ragab Mahmoud
Published: September 2023

The Internet of Things (IoT) is the most extensively utilized technology nowadays that is simple and has the advantage of replacing the data with other devices by employing cloud or wireless networks. However, cyber-threats and cyber-attacks significantly affect smart applications on these IoT platforms. The effects of these intrusions lead to economic and physical damage. The conventional IoT security approaches are unable to handle the current security problems since the threats and attacks are continuously evolving. In this background, employing Artificial Intelligence (AI) knowledge, particularly Machine Learning (ML) and Deep Learning (DL) solutions, remains the key to delivering a dynamically improved and modern security system for next-generation IoT systems. Therefore, the current manuscript designs the Honey Badger Algorithm with an Optimal Hybrid Deep Belief Network (HBA-OHDBN) technique for cyberattack detection in a blockchain (BC)-assisted IoT environment. The purpose of the proposed HBA-OHDBN algorithm lies in its accurate recognition and classification of cyberattacks in the BC-assisted IoT platform. In the proposed HBA-OHDBN technique, feature selection using the HBA is implemented to choose an optimal set of features. For intrusion detection, the HBA-OHDBN technique applies the HDBN model. In order to adjust the hyperparameter values of the HDBN model, the Dung Beetle Optimization (DBO) algorithm is utilized. Moreover, BC technology is also applied to improve network security. The performance of the HBA-OHDBN algorithm was validated using the benchmark NSLKDD dataset. The extensive results indicate that the HBA-OHDBN model outperforms recent models, with a maximum accuracy of 99.21%.
Intelligent Fault Diagnosis of Robotic Strain Wave Gear Reducer Using Area-Metric-Based Sampling
Authors: Noh Yeong Rim , Khalid Salman , Kim Heung Soo , Choi Seung-Kyum
Published: September 2023

The main challenge with rotating machine fault diagnosis is the condition monitoring of machines undergoing nonstationary operations. One possible way of efficiently handling this situation is to use the deep learning (DL) method. However, most DL methods have difficulties when the issue of imbalanced datasets occurs. This paper proposes a novel framework to mitigate this issue by developing an area-metric-based sampling method. In the proposed process, the new sampling scheme can identify which locations of the datasets can potentially have a high degree of surprise. The basic idea of the proposed method is whenever significant deviations from the area metrics are observed to populate more sample points. In addition, to improve the training accuracy of the DL method, the obtained sampled datasets are transformed into a continuous wavelet transform (CWT)-based scalogram representing the time–frequency component. The dilated convolutional neural network (CNN) is also introduced as a classification process with the altered images. The efficacy of the proposed method is demonstrated with fault diagnosis problems for welding robots. The obtained results are also compared with existing methods.
Phyllofenones F–M, Scalarane Sesterterpenes from the Marine Sponge Phyllospongia foliascens
Authors: Yu Hao-Bing , Hu Bo , Ning Zhe , He Ying , Men Xiao-Ling , Yin Zi-Fei , Jiao Bing-Hua , Liu Xiao-Yu , Lin Hou-Wen
Published: September 2023

Eight new scalarane sesterterpenes, phyllofenones F–M (1–8), together with two known analogues, carteriofenones B and A (9–10), were isolated from the marine sponge Phyllospongia foliascens collected from the South China Sea. The structures of these compounds were determined based on extensive spectroscopic and quantum chemical calculation analysis. The antibacterial and cytotoxic activity of these compounds was evaluated. Among them, only compounds 4 and 6 displayed weak inhibitory activity against Staphylococcus aureus and Escherichia coli, with MIC values of 16 μg/mL and 8 μg/mL, respectively. Compounds 1–10 exhibited cytotoxic activity against the HeLa, HCT-116, H460, and SW1990 cancer cell lines, with IC50 values ranging from 3.4 to 19.8 μM.