bluuebunny/crossref_metadata_2025 huggingface dataset:
Morning Salivary Cortisol Has a Positive Correlation with GAD-7 Scores in Patients with Ulcerative Colitis
Authors: Castro Cristina M. , Mithal Aditya , Deyhim Tina , Rabinowitz Loren G. , Olagoke Olawande , Freedman Steven D. , Cheifetz Adam S. , Ballou Sarah K. , Papamichael Konstantinos
Published: November 2024

Objectives: Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn’s disease (CD). Earlier onset of IBD symptoms has been linked to a higher prevalence of depression and anxiety. Evidence supports that cortisol abnormalities correlate with the development and severity of autoimmune diseases. The primary aim of this study was to investigate the correlation of morning salivary cortisol levels with self-reported mood (depression and anxiety) and quality of life in patients with IBD. Methods: This was a prospective, single-center study including outpatients with IBD. Enrolled patients provided a one-time morning salivary cortisol sample and electronically completed a one-time survey encompassing self-reported quality of life (Short Inflammatory Bowel Disease Questionnaire (SIBDQ)) and mood (Patient Health Questionnaire 8 (PHQ-8), General Anxiety Disorder-7 (GAD-7)). Results: A total of 36 patients (UC, n = 21) were included in the study. There was no correlation between morning salivary cortisol and depressive symptoms (PHQ-8: r = 0.007, p = 0.968) or quality of life (SIBDQ: r = −0.095, p = 0.606). However, there was a trend towards a positive correlation between self-reported anxiety symptoms by GAD-7 and salivary cortisol (r = 0.347, p = 0.052). A subgroup analysis showed a positive correlation between morning salivary cortisol and GAD-7 scores in patients with UC (r = 0.535, p = 0.015), but not in patients with CD (r = 0.064, p = 0.843). Conclusions: This pilot study is the first to associate cortisol with anxiety symptom severity in UC. Further research is needed to investigate the link between salivary cortisol, neuropsychiatric disease, and IBD outcomes.
Study on Pharmacological Treatment of Impulse Control Disorders in Parkinson’s Disease
Authors: Furdu-Lunguț Emilia , Antal Claudia , Turcu Suzana , Costea Dan-Gabriel , Mitran Mihai , Mitran Loredana , Diaconescu Andrei-Sebastian , Novac Marius-Bogdan , Gorecki Gabriel-Petre
Published: November 2024

Parkinson’s disease is neurodegenerative, and additionally, a percentage higher than 60% is represented by the patients with associated psychiatric symptoms, such as anxiety disorders and depression. Due to illness itself and to therapy secondary effects, there is a high risk for these patients to develop impulse control disorders like ICDs: compulsive shopping, pathological gambling binge eating disorder, and hypersexuality. There is high interest in therapy so as to diminish, as much as possible, the associated ICD symptoms. This article presents a study on pharmacological treatment of impulse control disorders in Parkinson disease carried on a sample of patients in hospitals where the authors have their clinical work. This study was carried on for a period of 6 years and is focused on research of different treatment plans. The patients were evaluated by the Hamilton Rating Scale. Statistical analysis of the obtained data (given by the HAM-A scores) is used for data processing. All patients showed a reduction in their impulse behavior. The directions of further research development are mentioned.
The Role of Glucose–Lymphocyte Ratio in Evaluating the Severity of Coronary Artery Disease
Authors: Serhatlioglu Faruk , Cetinkaya Zeki , Yilmaz Yucel
Published: November 2024

Background: Recently, a new inflammatory and prognostic marker called glucose/lymphocyte ratio (GLR) has been used in patients with coronary artery disease. In this study, we analyzed the correlation between GLR and coronary artery disease (CAD) severity in patients with chronic coronary syndrome (CCS). Methods: The study included 341 patients with CCS who underwent coronary angiography and documented coronary stenosis of 50% or more in at least one major coronary artery and 437 individuals with coronary atherosclerosis between 1% and 50% or no coronary atherosclerosis (control group). Blood samples for GLR and other laboratory parameters were obtained from all patients on admission. GLR was obtained by dividing the glucose level by the lymphocyte count. Results: There were more patients with diabetes mellitus (DM) in the critical CAD group, and glucose levels (p < 0.001), neutrophil counts (p < 0.001), C-reactive protein (CRP) levels (p < 0.001), neutrophil/lymphocyte ratio (NLR) (p < 0.001), platelet/lymphocyte ratio (PLR) (p < 0.001), and GLR (p < 0.001) were higher. In contrast, lymphocyte counts were lower (p < 0.034). Multivariate logistic regression analysis showed that DM and high CRP were independent predictors of critical CAD (p = 0.004 and p = 0.048, respectively). However, high GLR was found to be an independent predictor of critical CAD (p < 0.001). Conclusions: GLR, a simple and easily measured marker, has shown strong predictive value for CAD severity in CCS patients.
Safety and Efficacy of Atogepant for the Preventive Treatment of Migraines in Adults: A Systematic Review and Meta-Analysis
Authors: Alrasheed Abdulrahim Saleh , Almaqboul Taif Mansour , Alshamrani Reem Ali , AlMohish Noor Mohammad , Alabdali Majed Mohammad
Published: November 2024

Background: Migraine is a common neurological condition marked by unilateral recurrent pulsating headaches, often associated with systemic signs and symptoms. Recently, calcitonin gene-related peptide (CGRP) antagonists, including atogepant, an oral CGRP receptor antagonist, have emerged as effective and safe treatments. The current study sought to assess the efficacy and safety of atogepant for preventing episodic migraines in adults. Methods: A comprehensive search, following PRISMA guidelines, was conducted using PubMed, Web of Science, and Cochrane Library to identify randomized, double-blind, placebo-controlled trials published up to June 2024. Results: The studies included adult participants with episodic migraine treated with atogepant. The primary outcomes assessed were changes in mean monthly migraine days (MMDs) and monthly headache days (MHDs) over 12 weeks. Secondary outcomes included reduction in acute medication use, 50% responder rates, and adverse events. A meta-analysis using a random-effects model was performed to evaluate efficacy and safety. Six trials with 4569 participants were included. Atogepant significantly reduced mean monthly migraine days (MMDs) and monthly headache days (MHDs) compared to placebo at all doses (10 mg, 30 mg, 60 mg), with the 60 mg dose showing the greatest reduction (mean difference: −1.48 days, p < 0.001). Significant reductions in acute medication use and improved 50% responder rates were also observed for all doses. The safety profile of atogepant was favorable, with common adverse events being mild to moderate, such as constipation and nausea. There were no significant differences in serious adverse events between the atogepant and placebo groups. Conclusions: Atogepant is an effective and well-tolerated option for preventing episodic migraines, showing significant reductions in migraine frequency and acute medication use. However, further studies are necessary to assess its long-term safety and efficacy, especially at higher doses, and to investigate its potential role in personalized treatment strategies for migraine prevention.
Peripheral Ameloblastoma: A Case Report and Review of Literature
Authors: Decani Sem , Quatrale Martina , Caria Veronica , Moneghini Laura , Varoni Elena Maria
Published: November 2024

Peripheral ameloblastoma (PA) is a rare benign tumor that can occur mostly in the mandibular gingiva of the premolar area, originating from the residual odontogenic epithelium. The patient is usually asymptomatic and the lesion can be an occasional finding during routine intraoral examination. Due to the lack of clinical and radiographic pathognomonic features, the diagnosis is based on histopathological analysis, associated with 3D computed tomography (CT) imaging. Here, we report the case of a middle-aged man showing an asymptomatic, sessile, normochromic papillomatous mass of the lingual alveolar mucosa, in correspondence of tooth 4.4, which was histologically diagnosed as peripheral ameloblastoma. After the complete excision of the lesion, there were no recurrence and no symptoms during the 3-year follow-up. The treatment of choice for PA is a conservative surgical excision, which usually results in a good prognosis, together with a long-term follow-up, necessary to intercept possible recurrence or, more rarely, malignant transformation.
Vitamin C and Tuberculosis: Examining the Relationship Between Antioxidant Defense and Disease Severity—Preliminary Findings from a Southwestern Romanian Study
Authors: Cioboata Ramona , Nicolosu Dragos , Balasoiu Andrei-Theodor , Balteanu Mara Amalia , Zlatian Ovidiu Mircea , Osman Andrei , Biciusca Viorel , Tieranu Eugen-Nicolae , Mogos Gabriel Florin Razvan , Ghenea Alice Elena
Published: November 2024

Background/Objectives: This study explored the relationship between serum vitamin C levels, antioxidant defense mechanisms, and the severity of pulmonary tuberculosis (TB) among Romanian patients. Methods: This study enrolled 53 patients with bacteriologically confirmed pulmonary tuberculosis at Victor Babes University Hospital in Craiova between January 2023 and August 2024. Participants were stratified into two groups based on their serum vitamin C levels: 26 patients with normal levels and 27 patients with low levels. Clinical, demographic, and biological parameters, including inflammatory markers, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), were assessed at baseline and after 60 days of TB treatment. Serum vitamin C levels were measured using ELISA. The persistence of Mycobacterium tuberculosis (MTB) was evaluated using sputum smear microscopy and culture at baseline and after 2 months of treatment. Results: The results showed that patients with low vitamin C levels had significantly higher baseline ESR (92.63 ± 27.69 mm/h) and CRP (43.89 ± 12.00 mg/L) levels compared to those with normal levels (ESR: 65.11 ± 13.27 mm/h, CRP: 31.19 ± 9.76 mg/L). After 60 days, 66.67% of patients with low vitamin C levels remained culture-positive compared to 26.92% in the normal vitamin C group (p = 0.004). Multivariate analysis indicated that vitamin C deficiency was significantly associated with a higher TB culture load. Conclusions: These findings suggest that vitamin C deficiency may contribute to the persistence of MTB and highlight the potential role of vitamin C supplementation as an adjunct to standard TB treatment, particularly in the context of global efforts to eradicate the disease by 2035.
Cataract Prevalence in Patients with Cutaneous Melanoma in Lithuanian Population
Authors: Šemeklis Lukas , Kapitanovaitė Laura , Butrimas Grinvydas , Briedė Kamilija , Račkauskaitė Laura , Žemaitienė Reda , Valiukevičienė Skaidra
Published: November 2024

Background/Objectives: Sun exposure and ultraviolet (UV) radiation significantly affect human health, especially concerning skin and eye conditions. Sun exposure is a risk factor for both cutaneous melanoma (CM) and cataract. To investigate the association between CM, cataract and the number of common melanocytic nevi (CMNs) in the Lithuanian population. Methods: A case–control study with 180 primary diagnosed CM subjects and 182 healthy controls was conducted. Participants underwent ophthalmic and dermatological examination, where a counting of the common melanocytic nevi (CMNs) on the face, outer surfaces of the upper arms, lower arms and hands was performed. A detailed ophthalmic slit lamp examination was conducted; additionally, lens status and cataract formation were evaluated according to the Lens Opacities Classification System III (LOCS III). Results: Subjects with an LOCS III grade of nuclear opalescence (NO) ≥3 had a 1.82 times higher risk of CM, and patients with a nuclear color (NC) grade ≥3 had a 2.02 times higher risk of CM. LOCS III evaluations of cortical (C) and of posterior subcapsular (P) cataract showed a 5.24 and 6.34 times increased risk of CM, respectively. The CMN number on the face increased CM risk by 1.25 times; on the outer surface of the upper and lower arms, correspondingly 1.05 and 1.04 times; and on outer surface of hands—1.29 times. Conclusions: All types of cataracts were found more often in patients with CM than in healthy subjects. The number of CMNs on the face and outer surfaces of arms and hands could be an indicator of higher risk for CM.
Mirror Aneurysms of the Pericallosal Artery Clipped During a Single Surgical Procedure: Case Report and Literature Review
Authors: Toader Corneliu , Radoi Mugurel Petrinel , Brehar Felix-Mircea , Serban Matei , Glavan Luca-Andrei , Covache-Busuioc Razvan-Adrian , Ciurea Alexandru Vlad , Dobrin Nicolae
Published: November 2024

Pericallosal artery aneurysms are rare, accounting for 2–9% of all intracranial aneurysms, and mirror aneurysms in this location are exceptionally uncommon, presenting unique surgical challenges due to their deep location and proximity to critical neurovascular structures. The aim of this case report is to describe the surgical management and successful outcome of a patient with mirror pericallosal artery aneurysms and to contribute insights into the clinical and surgical considerations for this rare condition. We report the case of a 71-year-old female with multiple cardiovascular and metabolic conditions, including hypertension and smoking—well-established risk factors for intracranial aneurysm formation and rupture. She presented with a Hunt and Hess grade II subarachnoid hemorrhage resulting in communicating internal hydrocephalus. Preoperative angiography revealed mirror aneurysms of the pericallosal artery. The patient underwent a left basal paramedian frontal craniotomy, during which a ruptured aneurysm on the right A2 segment and an unruptured aneurysm on the left A2 segment were identified. Both aneurysms were successfully clipped using curved Yasargil clips. Postoperative recovery was favorable, with no neurological deficits and stable imaging findings at a three-month follow-up. This case underscores the necessity for precise microsurgical intervention and a thorough understanding of pericallosal artery anatomy to manage such rare and challenging conditions effectively. The role of hyperlipidemia and statin use in intracranial aneurysm development remains debated and warrants further investigation. Our successful management of mirror pericallosal artery aneurysms contributes to the limited literature on this rare condition and highlights the importance of meticulous surgical techniques for favorable outcomes.
Sepsis-Associated Acute Kidney Injury in Critically Ill Children: Incidence and Outcomes
Authors: Shalaby Mohammad A. , Alhasan Khalid A. , Sandokji Ibrahim A. , Albanna Amr S. , Almukhtar Zahrah , Elhaj Hind Khalifa , Alwadai Khaled , Bahassan Abdulaziz , Temsah Mohamad-Hani , Raina Rupesh , Kari Jameela A.
Published: November 2024

Background: Acute kidney injury (AKI) is a major concern in pediatric critical care, often occurring in conjunction with sepsis. This study aimed to identify the incidence, outcomes, and risk factors for AKI in the context of pediatric sepsis. Methods: This was a bicentric retrospective cohort study conducted at two university hospitals in Saudi Arabia. All patients aged 1 month to 14 years admitted to pediatric intensive care units (PICUs) with evidence of sepsis between January 2021 and December 2022 were included. AKI was defined and staged according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Demographic, clinical, and laboratory data were collected from electronic medical records. Results: 309 patients were included, 38 (12.3%) developed stage 1 AKI, 64 (20.7%) developed stage 2 AKI, and 183 (59.2%) developed stage 3 AKI. Patients with sepsis-associated AKI had significantly longer PICU stays and higher mortality rates than those without AKI (p < 0.01). Inflammatory markers and certain medications were associated with increased AKI risk. Factors independently associated with stage 3 AKI include younger age, positive blood culture, gentamycin use, and higher SOFA score. Conclusions: Sepsis-associated AKI is a common and serious complication in critically ill children, contributing to increased morbidity and mortality. Identification of specific risk factors may facilitate early recognition and targeted interventions to mitigate the impact of AKI in this vulnerable population.
Correlation Between Reduced Daily Living Competence and the Risk of Postoperative Delirium in Orthopedics and Trauma Surgery
Authors: Rahm Louisa Katharina , Moellmann Henriette Louise , Stenmanns Carla , Schiffner Erik , Windolf Joachim , Frohnhofen Helmut , Latz David
Published: November 2024

Background/Objectives: Postoperative delirium is a prevalent and serious complication among elderly patients following surgical procedures. Prior research indicates that reduced competence in daily living, as evidenced by limitations in performing Activities of Daily Living (ADL), is directly associated with reduced patient mobility. This study aimed to investigate the potential role of preoperative mobility as a risk factor for the development of postoperative delirium. Methods: To assess preoperative mobility, a comprehensive geriatric evaluation of daily living competence was conducted. This included the Katz Index of Independence in ADL, which assessed basic daily activities over the preceding 14 days, and the Instrumental Activities of Daily Living Scale (IADL). Postoperatively, delirium monitoring was performed twice daily for seven days using validated delirium screening tools, including the Nursing Delirium Screening Scale, the Confusion Assessment Method, and the 4ATest. Results: A significant correlation was observed between the incidence of delirium and the IADL scores in all patients, with p < 0.001 for men and p = 0.001 for women. Among emergency patients, the Katz Index scores significantly differed between those who developed delirium and those who did not (p = 0.015). Additionally, a significant correlation was found between the Katz Index and the incidence of delirium in both groups (p < 0.001). Conclusions: The findings of this study emphasize the necessity of preoperative geriatric assessment using tools such as the Katz Index or IADL to identify patients at risk of delirium. The results confirm the importance of enhanced postoperative monitoring for potential delirium. For elective patients, prehabilitation should be considered when reduced daily living competence is identified. For emergency patients, immediate postoperative interventions, including intensive mobilization and orthogeriatric co-management, are recommended.
Feasibility of Home-Based Early Infant Hybrid Therapy in Children with Unilateral Cerebral Palsy
Authors: Palomo-Carrión Rocío , Romay-Barrero Helena , Pinero-Pinto Elena , Romero-Galisteo Rita-Pilar , Coello-Villalón María , Ferri-Morales Asunción , López-Muñoz Purificación , Lirio-Romero Cristina
Published: November 2024

Background: The first stage of childhood is characterized by great neuronal plasticity. In Unilateral Cerebral Palsy (UCP), it is essential to carry out early treatment, with family involvement. The aim of this study was to investigate the feasibility of Early Infant Hybrid Therapy (eI-Hybrid) applied at home with family involvement in children with UCP aged 9–18 months, and to assess its preliminary effectiveness on bimanual functional performance. Methods: A single group of 10 children (12.8 months, SD = 3.4) performed the eI-Hybrid therapy. The main outcome was measured with the mini Assisting Hand Assessment scale (mini-AHA), functional goals were measured with the Goal Attainment Scale (GAS), and satisfaction expectations on intensive therapy were also recorded. Three measures were performed (week 0, week 10, and month 6). A repeated-measures ANOVA test was performed on the mini-AHA in order to observe the statistically significant differences in pairwise comparison. Results: Ten children completed the study and the parents’ expectations were fulfilled, indicating high caregiver compliance and high adherence to the treatment. Clinically relevant changes were observed between pre- and post-intervention measurements in BFP (pre: 41.9 (SD: 7.7), post: 50.9 (SD: 6.0) and in the follow-up at 6 months (50.3 (SD:5.6); p < 0.001). Families reported a high satisfaction. Conclusions: infant hybrid treatment is feasible to be performed at home with the family’s involvement, obtaining improvements in the affected upper limb for early-age UCP.
Psychotic-like Experiences and Underlying Mechanisms: An Integrative Model of ADHD Symptoms, Rumination, Negative Affect, and Trauma Experience
Authors: Gelner Hanna , Bagrowska Paulina , Jeronimus Bertus F. , Misiak Błażej , Samochowiec Jerzy , Gawęda Łukasz
Published: November 2024

Background: Psychotic-like experiences (PLEs) are low-intensity subclinical phenomena, often transient in nature. The etiology of PLEs primarily involves neurodevelopmental changes, trauma exposure, and maladaptive coping styles. Attention-Deficit/Hyperactivity Disorder (ADHD) is considered to be one of the factors that increase the risk of future psychosis. Furthermore, ADHD symptoms predict a heightened incidence of traumatic experiences, ruminative thoughts, and negative affect (NA). This present study examines whether rumination and NA mediate the relationship between ADHD symptoms and PLEs and whether trauma experiences moderate these pathways. Methods: A total of 188 participants (72% female) aged 18–35 completed questionnaires assessing ADHD symptoms and traumatic experiences and took part in a seven-day experience sampling method (ESM) procedure, completing ratings of PLEs experiences, the intensity of ruminations, and NA. Results: Correlation analysis showed significant relationships between all tested variables. Serial mediation analysis revealed a significant indirect effect of rumination and NA in the link between ADHD symptoms and PLEs. There was no significant impact of trauma experience in this relationship. Conclusions: Our study underscores the important role of rumination and NA in the co-development of ADHD symptoms and PLEs. Future research should consider investigating the intra-individual dynamics of ADHD and trauma using ecologically valid research methods in the context of PLEs to better understand these complex relationships.
Ankle Taping Does Not Affect Running Kinematics During a Treadmill Protocol in Well-Trained Runners: A Secondary Analysis from a Randomized Cross-Over Controlled Trial
Authors: Salniccia Federico , López-Ruiz Javier , García-Pérez-de-Sevilla Guillermo , González-de-la-Flor Ángel , García-Arrabé María
Published: November 2024

Background: The purpose of this randomized cross-over controlled trial was to evaluate the biomechanical effects of ankle taping using rigid tape (RT) or kinesiotape (KT) compared to no taping during treadmill running in well-trained amateur runners. Methods: A total of 22 participants (15 men and 7 women) completed three running sessions on a treadmill, each lasting 30 min, under different conditions: no taping (CG), RT, and KT. Sagittal and frontal plane kinematics were analyzed using the Kinovea software to assess the ankle dorsiflexion, knee flexion, hip extension, tibial angle, foot strike pattern, heel eversion, and pelvic drop across three intervals (0–10, 10–20, and 20–30 min). Results: The results demonstrated no significant differences in sagittal plane variables (ankle dorsiflexion, knee flexion, hip extension, and cadence) or frontal plane variables (heel eversion and pelvic drop) between the CG, RT and KT groups at any time point. Although heel eversion significantly increased over time due to fatigue, the taping conditions did not affect running kinematics. Conclusions: These findings suggest that neither RT nor KT alters running biomechanics in well-trained runners over prolonged treadmill running. The study highlights that taping, commonly used to prevent ankle injuries, does not significantly modify lower limb kinematics in the absence of injury. Further research is needed to evaluate the effects of taping in novice or injured runners and under more demanding conditions, such as overground running.
Recent Experimental Advances in Solid–Liquid Composites for Impact and Blast Mitigation
Authors: Li Mingzhe , McCoy Robert , Lu Weiyi
Published: November 2024

The development of high-performance composites for mechanical energy dissipation during impact or explosive events is of vital importance for the safety of personnel and infrastructures. Solid–liquid composites are an emerging class of energy absorbers where a liquid-phase filler is seamlessly integrated into a solid matrix to enhance the impact resistance of the protection target. This innovative approach leverages the distinct properties of both phases and the unique interactions between them to achieve superior performance under high-impact conditions. This paper aims to review the liquid-phase materials used in solid–liquid composites, ranging from neat liquids to complex fluids, including liquid nanofoam and shear-thickening fluids, to provide an in-depth analysis of the fundamental physics underpinning the resulting solid–liquid composites, and to explore how their unique properties contribute to enhanced impact resistance and energy absorption. Furthermore, this paper evaluates the advantages and limitations of these solid–liquid composites and offers insights into future directions for the development of solid–liquid composites in various fields, including personal protective equipment, automotive safety systems, and structural protection.
Development and Evaluation of Thread Transistor Based on Carbon-Nanotube Composite Thread with Ionic Gel and Its Application to Logic Gates
Authors: Kodaira Hiroki , Oya Takahide
Published: November 2024

We propose a new type of flexible transistor based on carbon-nanotube (CNT) composite thread (CNTCT), i.e., a thread transistor, with ionic gel. In our previous study, we demonstrated that transistor operation was possible by combining metallic and semiconducting CNTCTs as gate and channel with an insulating material. However, its performance was not sufficient. Therefore, we here aim to improve it. For this, we tried to apply ionic gel as a dielectric layer to it. With this, the transistor was expected to be an electric-double-layer transistor. The transistor performance was improved, and the on/off ratio of the transistor increased by more than 4. This is a large value compared to our previous work. In addition, we not only evaluated the performance of the transistors, but also investigated whether they could be used as logic circuits. It was confirmed that the logic circuit composed of the thread transistor also operated correctly and stably for a long period of time. It was also confirmed that the output changed in response to weak external forces. These results indicate that it is a flexible transistor that can be used in a wide range of applications such as logic circuits and sensors.
Biocomposites Based on Polyethylene/Ethylene–Vinyl Acetate Copolymer/Cellulosic Fillers
Authors: Shelenkov P. G. , Pantyukhov P. V. , Krivandin A. V. , Popov A. A. , Khaidarov B. B. , Poletto M.
Published: November 2024

This work studied biocomposites based on a blend of low-density polyethylene (LDPE) and the ethylene–vinyl acetate copolymer (EVA), filled with 30 wt.% of cellulosic components (microcrystalline cellulose or wood flour). The LDPE/EVA ratio varied from 0 to 100%. It was shown that the addition of EVA to LDPE increased the elasticity of biocomposites. The elongation at break for filled biocomposites increased from 9% to 317% for microcrystalline cellulose and from 9% to 120% for wood flour (with an increase in the EVA content in the matrix from 0 to 50%). The biodegradability of biocomposites was assessed both in laboratory conditions and in open landfill conditions. The EVA content in the matrix also affects the rate of the biodegradation of biocomposites, with an increase in the proportion of the copolymer in the polymer matrix corresponding to increased rates of biodegradation. Biodegradation was confirmed gravimetrically by weight loss, an X-ray diffraction analysis, and the change in color of the samples after exposition in soil media. The prepared biocomposites have a high potential for implementation due to the optimal combination of consumer properties.
Kinesiological Rehabilitation in a Young Adult with Biceps Femoralis Arteriovenous Malformation: A Case Study
Authors: Di Martino Giulia , della Valle Carlo , Centorbi Marco , Bovolenta Paola , Fiorilli Giovanni , Calcagno Giuseppe , di Cagno Alessandra , Iuliano Enzo
Published: November 2024

Background/Objectives: This case study involved a 24-year-old male with an arteriovenous malformation localized in the long head of the right biceps femoris muscle, with an anterior cruciate ligament injury. The aim was to assess the effects of a five-week kinesiological protocol, which included global postural re-education and strengthening exercises focused on knee stabilization. Methods: The effectiveness of the therapeutic intervention was evaluated using Gait Analysis, clinical examination, and the SF-36 questionnaire to assess the patient’s quality of life. Results: The study revealed significant postural improvements, including the restoration of the spine’s physiological curves, with kyphosis angles measuring 44.7° in indifferent orthostasis and 41.7° in self-corrected standing; and lumbar lordosis measuring 32.8° in indifferent orthostasis and 41.9° in self-corrected standing. Additionally, there was a restoration of the correct knee, hip, and ankle angles, along with a shift in the principal axis of the center of pressure from 7.6° pre-intervention to 12.9° post-intervention. The patient’s perception of physical efficiency also improved, increasing from 60% to 75% over the treatment period. Conclusions: The effectiveness of the kinesiological treatment was confirmed by the improvement in gait stability and overall strengthening. The patient’s active involvement in the treatment process enhanced his confidence in its success, ensuring adherence to the protocols.
The Effects of Physical Activity and the Consequences of Physical Inactivity in Adult Patients with Congenital Heart Disease During the COVID-19 Pandemic
Authors: Pomiato Elettra , Palmieri Rosalinda , Panebianco Mario , Di Già Giulia , Della Porta Marco , Turchetta Attilio , Raponi Massimiliano , Gagliardi Maria Giulia , Perrone Marco Alfonso
Published: November 2024

Background: The ongoing COVID-19 pandemic has infected more than 500 million people worldwide. Several measures have been taken to reduce the spread of the virus and the saturation of intensive care units: among them, a lockdown (LD) was declared in Italy on 9 March 2020. As a result, gyms, public parks, sports fields, outdoor play areas, schools, and multiple commercial activities have been closed. The consequences of physical inactivity can be dramatic in adult patients with congenital heart disease (ACHD), in which the benefit of regular exercise is well known. In this study, we investigated the effects of reduced physical activity during the COVID-19 pandemic on ACHD’s exercise capacity. Materials and Methods: Patients who performed exercise or cardiopulmonary exercise tests from October 2019 to February 2020 and one year after lockdown with the same protocol were retrospectively enrolled in our database. Inclusion criteria: ACHD patients aged ≥ 18 years old under regular follow-up. Exclusion criteria: significant clinical and/or therapeutic changes between the two tests; significant illness occurred between the two tests, including COVID-19 infection; interruption of one of the tests for reasons other than muscle exhaustion. Results: Thirty-eight patients (55.6% males) met the inclusion criteria. Before the lockdown, 17 patients (group A) were engaged in regular physical activity (RPA), and 20 patients (group B) had a sedentary lifestyle. After LD, in group A, (a) the weekly amount of physical activity reduced with statistical significance from 115 ± 46 min/week to 91 ± 64 min/week (−21%, p = 0.03); (b) the BMI did not change; (c) the duration of exercise test and VO2 max at cardiopulmonary exercise test showed a significant reduction after the LD. In group B, BMI and exercise parameters did not show any difference. Conclusions: The COVID-19 pandemic dramatically changed the habits of ACHD patients, significantly reducing their possibility to exercise. Our data analyzed in this extraordinary situation again demonstrated that physical inactivity in ACHD worsens functional capacity, as highlighted by VO2 max. Regular exercise should be encouraged in ACHD patients to preserve functional capacity.
Circadian Rhythm and Physical Fatigue Separately Influence Cognitive and Physical Performance in Amateur Athletes
Authors: Karanika Panagiota , Gallardo Philip , Tsatalas Themistoklis , Giakas Giannis , Tsaklis Panagiotis V.
Published: November 2024

Background/Objectives: Circadian rhythm (CR) influences various physiological functions, including physical and cognitive performance, which fluctuate throughout the day. The present study aimed to investigate the combined and separate effects of CR and physical fatigue on cognitive and physical performance. Methods: A sample of 18 amateur athletes was subjected to a series of tests at three different times of the day: morning, afternoon, and evening. Fatigue was induced following an isokinetic concentric exercise combined with a 20 min treadmill run, followed by assessments of selected physical and cognitive tasks. Results: A repeated measure ANOVA did not reveal an interaction between CR and fatigue in cognitive performance (p > 0.05). However, a significant main effect of fatigue was observed in visual reaction time (VisRT) across all three timepoints. Moreover, peak torque (PT) and the peak torque fatigue index (PTFI) showed significant differences between the three times of the day, peaking in the evening. Conclusions: Although we found no interaction between CR and the physical fatigue state on selected cognitive parameters at the three times of the day, a separate effect of fatigue on cognitive performance was identified. Additionally, physical parameters exhibited peak values occurring in the evening hours. Future research should further explore underlying mechanisms that potentially influence cognitive performance at different times of the day.
Thermal Management of Friction-Drilled A356 Aluminum Alloy: A Study of Preheating and Drilling Parameters
Authors: Abdalkareem Ahmed , Afify Rasha , Hamzawy Nadia , Mahmoud Tamer S. , Khedr Mahmoud
Published: November 2024

Friction drilling is a non-conventional process that generates heat through the interaction between a rotating tool and a workpiece, forming a hole with a bushing. In this study, the effect of the preheating temperature, rotational speed, and feed rate on the induced temperature during the friction drilling of A356 aluminum alloy was investigated. This study aimed to analyze the influence of friction-drilling parameters on the thermal conditions in the induced bushing, where it focused on the relationship between preheating and the resulting heat generation. The analysis of variance (ANOVA) approach was carried out to optimize the friction-drilling parameters that contributed most to the induced temperature during the friction-drilling processing. Experiments were conducted at various preheating temperatures (100 °C, 150 °C, 200 °C), rotational speeds (2000 rpm, 3000 rpm, 4000 rpm), and feed rates (40 mm/min, 60 mm/min, 80 mm/min). The induced temperature during the process was recorded using an infrared camera, where the observed temperatures ranged from a minimum of 154.4 °C (at 2000 rpm, 60 mm/min, and 100 °C preheating) to a maximum of 366.8 °C (at 4000 rpm, 40 mm/min, and 200 °C preheating). The results show that preheating increased the peak temperature generated in the bushing during friction drilling, especially at lower rotational speeds. The rotational speed rise led to an increase in the induced temperature. However, the increase in the feed rate resulted in a decrease in the observed temperature. The findings provide insights into optimizing friction-drilling parameters for enhanced thermal management in A356 aluminum alloy.
Global Sensitivity Analysis of the Fundamental Frequency of Jacket-Supported Offshore Wind Turbines Using Artificial Neural Networks
Authors: Quevedo-Reina Román , Álamo Guillermo M. , Aznárez Juan J.
Published: November 2024

Determining the fundamental frequency of Offshore Wind Turbines (OWTs) is crucial to ensure the reliability and longevity of the structure. This study presents a global sensitivity analysis of the fundamental frequency of OWTs on jacket foundations. Monte Carlo sampling was employed to generate a diverse set of wind turbines, emplacements, and jacket designs, ensuring that the generated samples are realistic and yield relevant conclusions. The fundamental frequency and its partial derivatives were obtained via a previously developed ANN model. The relative sensitivities were computed to facilitate the comparison of their influence. The results demonstrate that wind turbine properties are the most relevant variables affecting the fundamental frequency, with a decrement in frequency caused by tower height and rotor-nacelle assembly mass, as well as an increment due to the section dimensions of the tower, particularly at its base. Soil properties have a significant effect on foundation stiffness for soft and light soils but can be neglected for hard and heavy soils. The diameter and thickness of the braces also show different relevance depending on their dimensions, producing rigid links between legs for greater sections. This study provides a measure of the variables influencing the fundamental frequency, facilitating a deeper comprehension of this phenomenon.
Study on the Vertical Distribution Characteristics of Suspended Sediment Driven by Waves and Currents
Authors: Wu Feng , Lian Jijian , Liu Fang , Yao Ye
Published: November 2024

Port coasts are affected by waves and tidal currents, and sediment continues to silt up, leading to a reduction in the depth of water in the channel, blocking the channel and seriously affecting the safe operation of ports. The main cause of sediment deposition in ports is suspended sediment transport, and the characteristics of the vertical distribution of suspended sediment concentrations are the embodiment of the suspended sediment transport law. This paper is divided into three parts to study the vertical distribution characteristics of suspended sediment concentrations. Firstly, the shortcomings of the traditional diffusion model were analysed by using the finite mixing theory (FMT); secondly, the sediment mixing length coefficient κs model was introduced and combined with the sediment group settling velocity model to establish the vertical distribution model of suspended sediment concentrations under wave–current; finally, the effects of various factors on the vertical distribution of the suspended sediment concentration were investigated. The results show that the model in this paper has the characteristics of “low variance and low bias”, which solves the problem that κs is difficult to determine. When the model κs < κs′ (κs′ = 0.4), the concentration of suspended sediment predicted by κs′ is overestimated, and vice versa. As the sediment concentration increases, the interaction between particles increases and the vertical distribution of the suspended sediment concentration shows the pattern of “small top and large bottom”. The larger the particle size, the greater the sedimentation rate of the suspended sediment, and a large amount of sediment will be suspended near the bottom without mixing. The higher the wave height, the stronger the boundary layer turbulence and the movement of the water particles’ trajectory, and the smaller the difference in sediment concentration between the bottom and the sea surface.
Media Portrayal of EU Commission and Its Leaders: A Content Analysis of Spanish Press (1976–2024)
Authors: Gallardo-Agudo Ángel , García-Borrego Manuel , Roses Sergio
Published: November 2024

The role of the media is key in mediating civil society and its political representatives in EU institutions. In this context, this paper aims to describe the representation of the European Commission, one of the EU’s most important institutions, and its leaders by two leading Spanish newspapers. In order to address this objective, an automated content analysis was carried out on 13,340 news items published between 6 June 1976 and 15 February 2024 in El País (social democratic media) and ABC (conservative, monarchist media). The sample was subjected to a sentiment analysis as well as topic modeling. The latter method made it possible to identify five predominant issues on the agenda: Economy, Foreign Affairs, Internal Politics, Spanish Politics, and the Future of the EU. The average sentiment, which is close to neutral, has tended slightly toward the negative over the years, although the current president, Ursula von der Leyen, has the highest rating of all the leaders studied. Both El País and ABC provide more negative coverage of the EU when leaders of their ideological opposition govern, a phenomenon that can weaken the European model and encourage political drifts with consequences that are difficult to predict in the medium term.
Is It Possible to Predict Difficulties During Laparoscopic Sleeve Gastrectomy? A Single Centre Experience
Authors: Pisarska-Adamczyk Magdalena , Stefura Tomasz , Małczak Piotr , Major Piotr , Wysocki Michał
Published: November 2024

Introduction: Laparoscopic sleeve gastrectomy (LSG) is a widely performed bariatric surgery across the globe. Understanding preoperative risk factors for possible intraoperative complications can aid in predicting surgical outcomes and shaping the approach to the procedure. This study aimed to identify and analyze potential risk factors associated with intraoperative difficulties during LSG. Patients and methods: The analysis encompassed consecutive patients who underwent LSG from 2017 to 2020. Patients who encountered intraoperative difficulties during the procedure were categorized into Group 1, whereas those who did not experience such complications were placed in Group 2. To identify potential risk factors for intraoperative challenges, a thorough evaluation of demographic characteristics was conducted, including variables such as age, body mass index (BMI), comorbidities, and previous surgical history. Results: Group 1 included 37 patients (11.71%), while Group 2 comprised 279 patients (88.29%). Apart from higher rates of diabetes, pulmonary disease, and sleep apnea in Group 1, no significant differences were observed between the groups regarding demographic parameters. A univariate logistic regression analysis identified several risk factors associated with intraoperative difficulties, including a body mass index (BMI) greater than 50 kg/m2 (OR 2.15, 95%, CI 1.05–4.39, p = 0.0362), the experience of the operating surgeon (OR 9.22, 95% CI 4.31–19.72, p = 0.0058), the presence of diabetes (OR 2.44, 95% CI 1.19–4.98, p = 0.0146), and pulmonary disease (OR 12.22, 95% CI 1.97–75.75, p < 0.0001). In multivariate logistic regression analysis, only the surgeon’s experience (OR 8.61, 95% CI 3.75–19.72, p < 0.0001) remained a significant factor influencing intraoperative difficulties. Conclusions: The sole significant factor influencing the occurrence of intraoperative difficulties was the level of the surgeon’s experience
Biomagnetic Monitoring of Urban Pollution: The Case of Aburrá Valley, Colombia
Authors: Goguitchaichvili Avto , Sánchez-Duque Alexander , Bautista Francisco , Cejudo Rubén , Cervantes Miguel
Published: November 2024

This study aims to identify the most polluted areas and sites using the magnetic signal of ornamental plant leaves as an indicator of environmental pollution. Systematic sampling was conducted with 98 sampling sites described according to urban land use, such as road hierarchy and road surface, soil group, collected plant species, and municipality. The magnetic parameters analyzed were low- and high-frequency magnetic susceptibility and the isothermal remanent magnetization acquisition curves in order to calculate the magnetic enhancement factor. For the analysis of variance, a Kruskal–Wallis test was performed to compare urban land uses. Subsequently, the magnetic enhancement factor in dust and surface soil was used to prepare maps of environmental pollution for each urban area. Analyses of the different magnetic parameters of the dust deposited on leaves show that low-coercivity ferrimagnetic minerals dominated the magnetic signal, probably magnetite of anthropic origin, and were closely linked to vehicular traffic and, to a lesser extent, industrial activities.
Reflexive-Reciprocal Syncretism in Eastern Bantu Languages of Tanzania: Distribution and Origins
Authors: Zahran Aron , Dom Sebastian
Published: November 2024

This paper presents an overview of the distribution of reflexive-reciprocal syncretism in Eastern Bantu languages spoken in Tanzania. Most Bantu languages encode reflexive and reciprocal constructions by means of two distinct verbal affixes. However, the Tanzanian Eastern Bantu languages under study have developed reflexive-reciprocal syncretism, in which the originally reflexive prefix has developed into a polyfunctional morpheme coding both reflexive and reciprocal constructions, to the detriment of the original reciprocal suffix. In a sample of 79 languages, reflexive-reciprocal syncretism is attested in 27 neighboring languages, thus constituting a clear areal feature. We propose that reflexive-reciprocal syncretism is not a language-internal innovation but was rather adopted from neighboring non-Bantu languages and subsequently spread out to its current distribution. We locate the heart of this contact-induced spread in the Tanzanian Rift Valley, a convergence zone in north-central Tanzania where languages from multiple African language families are spoken and have been in contact for an extensive period.