bluuebunny/crossref_metadata_2025 huggingface dataset:
A quantitative and qualitative assessment of sugar beet genotype resistance to root-knot nematode, Meloidogyne incognita
Authors: Gohar Ibrahim M. A. , Alyamani Amal , Shafi Manal E. , Mohamed Elshaimaa A. E. , Ghareeb Rehab Y. , Desoky Elsayed M. , Hasan Mohamed E. , Zaitoun Amera F. , Abdelsalam Nader R. , El-Tarabily Khaled A. , Elnahal Ahmed S. M.
Published: January 2023

Sugar beet productivity is highly constrained by the root-knot nematode (RKN) Meloidogyne incognita. Eight sugar beet genotypes were screened under greenhouse conditions for their susceptibility to M. incognita according to an adapted quantitative scheme for assignment Canto-Saenz’s host suitability (resistance) designations (AQSCS). Besides, the degree of susceptibility or tolerance of the examined genotypes was recorded by the modified host-parasite index (MHPI) scale based on yield performance. In addition, single nucleotide polymorphism (SNP) was also determined. Sugar beet genotypes have been classified into four categories for their susceptibility or tolerance according to the AQSCS scale. The first category, the moderately resistant (MR) group implies only one variety named SVH 2015, which did not support nematode reproduction (RF≤1), and had less root damage (GI≈2). Second, the tolerant group (T) involving Lilly and Halawa KWS supported fairly high nematode reproduction (RF>1) with relatively plant damage (GI≤2). Whereas the susceptible (S) category involved four varieties, FARIDA, Lammia KWS, Polat, and Capella, which supported nematode reproduction factor (RF>1) with high plant damage (GI>2). The fourth category refers to the highly susceptible (HYS) varieties such as Natura KWS that showed (RF≤1) and very high plant damage (GI>2). However, the MHPI scale showed that Lammia KWS variety was shifted from the (S) category to the (T) category. Results revealed significant differences among genotypes regarding disease severity, yield production, and quality traits. The SVH 2015 variety exhibited the lowest disease index values concerning population density with 800/250 cm3 soils, RF=2, root damage/gall index (GI=1.8), gall size (GS=2.3), gall area (GA=3.7), damage index (DI=3.4), susceptibility rate (SR=2.4), and MHP index (MHPI=2.5). However, Lammia KWS showed the highest disease index values regarding population density with 8890/250 cm3 soils, RF= 22.2, GI= 4.8, and SR= 14.1. Meanwhile, Natura KWS the highest GS, GA and MHPI with 7.1, 8 and 20.9, respectively. The lowest DI was achieved by Capella (DI= 6) followed by Lammia KWS (DI= 5.9). For yield production, and quality traits, SVH 2015 exhibited the lowest reductions of sugar yields/beet's root with 11.1%. While Natura KWS had the highest reduction with 79.3%, as well as it showed the highest reduction in quality traits; including sucrose, T.S.S, and purity with 65, 27.3, and 51.9%, respectively. The amino acid alignment and prediction of the DNA sequences revealed the presence of five SNPs among all sugar beet verities.
Adolescents at risk of eating disorders: The mediating role of emotional distress in the relationship between differentiation of self and eating disorders
Authors: Peleg Ora , Boniel-Nissim Meyran , Tzischinsky Orna
Published: January 2023

Introduction

Adolescents may feel dissatisfied with their bodies, which may lead to a risk of eating disorders (EDs) due to several factors, with emotional distress being one of the most important. Evidence suggests that family might be one of the most significant factors that may increase or decrease emotional distress. An important family pattern found to contribute to mental and physical health is the differentiation of self (DoS). The primary purpose of the current study was to map the complex relationships between DoS, emotional distress, and EDs among adolescents. We hypothesized that emotional distress would mediate the relationship between DoS and the risk of EDs among adolescents. Moreover, based on findings indicating a higher risk of EDs among females, we expected sex differences in the research indices and the mediation model.

Methods

The sample included 194 non-clinical adolescents (mean age 15.15; mean BMI 21.66). Preliminary analyses examined differences between males and females using t-tests. In addition, Pearson correlations were run to assess the association between background variables and the study metrics among males and females. To examine the mediation effect, we ran SEM.

Results

Due to a sex moderation effect, two mediation models were run (SEM), one for females and one for males. Results indicated that emotional distress partially mediated the relationships between DoS and the risk of EDs. In addition, sex differences were found in the mediated indices, showing that among female adolescents, perfectionism is the only dimension of EDs that was associated with DoS through the mediation of emotional distress. While the relationship between emotional distress and the risk of EDs is well documented.

Conclusions

It is concluded that high DoS may reduce emotional distress, which may, in turn, decrease the risk of EDs. In addition, the results enable an in-depth understanding of specific risk factors of EDs that characterize each sex.
Handedness in low-birthweight children: Insights in lateralization
Authors: Ittyerah Miriam
Published: January 2023

Low-birthweight (LBW) children (n = 96) weighing less than 2.5 kg at birth and normal birthweight (NBW) children (n = 96) from Delhi, India, between the ages of 5 and 12 years were assessed for intelligence with Ravens Colored Progressive Matrices (RCPM), their handedness and hand proficiency for unimanual and bimanual performance. The objective was to know if there is a relation between birthweight and the development of handedness. Compared with NBW children, the LBW group had lower percentile scores for the RCPM. The LBW children were less lateralized than the NBW children in the hand preference test. The LBW children were faster than the NBW for sorting objects with each hand separately, but they were slower in the bimanual envelope task. This indicates a delay in interhemispheric transfer and the development of the corpus callosum that connects the cerebral hemispheres to enable bimanual coordination. In the absence of more direct evidence, hand skill was used as an index of the extent of lateralized control for performance. Findings indicate a relation between birthweight and lateralization in children tested for hand preference.
The motive of competition but not courtship positively correlates with self-reported use of aggressive humor: A critical test of the contests- vs. mate-choice hypotheses
Authors: Duarte Brent , Zhang Jinguang
Published: January 2023

Introduction

The use of aggressive humor (e.g., teasing, schadenfreude, and sarcasm) is a spiteful behavior because it inflicts costs on both others and the self. To explain the existence of this spiteful behavior, two hypotheses derived from sexual selection theory—namely Mate-Choice and Contests—posit that the use of aggressive humor helps one attract mates or repel competitors. Both hypotheses have merit, but extant data are unable to discriminate between them.

Methods

We critically tested those two hypotheses with a survey study that measured 509 U.S. MTurkers’ self-reported tendencies to use aggressive (and other types of) humor, the motives to engage in competition and courtship, and the Dark-Triad personality traits. The final sample was N = 439.

Results

We found that (1) the motive of competition but not courtship positively and significantly correlated with the self-reported tendency to use aggressive humor. (2) Subclinical psychopathy—a personality trait positively associated with competition—mediated the correlation between the motive of competition and self-reported use of aggressive humor. These results were held in both female and male respondents.

Discussion

Our findings favored the Contests Hypothesis and helped reveal the psychological mechanism that generates the use of aggressive humor as a form of verbal aggression and spiteful behavior.
Can public service motivation increase work engagement?—A meta-analysis across cultures
Authors: Ding Mengxiao , Wang Chengli
Published: January 2023

Civil servants' work engagement is an essential topic in human resource management research of public sector. To explore the effects of public service motivation on civil service engagement as well as its mechanisms of action, and boundary conditions, this paper utilizes a meta-analytic approach to analyze 31 independent samples from 10 countries through literature search, screening, and coding. The result shows a significant positive relationship between public service motivation and work engagement with no possibility of publication bias. The regulatory effect test through Hofstede's model reveals that the dimensions of Power Distance Index, Individualism/Collectivism, Long-Term Orientation/Short-Term Orientation, and Indulgence/Restraint can significantly moderate the relationship between public service motivation and work engagement. This study provides a clear explanation for understanding the relationship between public service motivation and work engagement from a cross-cultural perspective, meanwhile it offers some theoretical implications for improving public servants' work engagement in the future.
Dispositional mindfulness and mental health among Chinese college students during the COVID-19 lockdown: The mediating role of self-compassion and the moderating role of gender
Authors: Zhang Dan , Shen Jianbo
Published: January 2023

College students’ mental health has been seriously impacted during the global COVID-19 lockdown. There is evidence that dispositional mindfulness is beneficial to mental health. However, few studies have looked at the relationship between dispositional mindfulness and mental health from the standpoint of self-compassion. Furthermore, it is unclear under what circumstances dispositional mindfulness is linked to mental health during COVID-19 lockdown. To fill this gap, the current study investigated self-compassion as a possible mediating factor and gender as a possible moderating effect between dispositional mindfulness and mental health. The sample included 1,018 Chinese university students during the COVID-19 lockdown (M age = 20.12; SD age = 1.17) who had completed self-report questionnaires on dispositional mindfulness, self-compassion, and mental health. According to the findings of mediation analysis, self-compassion partially mediated the relationship between dispositional mindfulness and mental health. The moderating analysis also revealed significant moderating effects of dispositional mindfulness, self-compassion, and mental health. Male college students’ mental health was significantly better protected, and the buffering effects of dispositional mindfulness and self-compassion on their mental health were significantly stronger than those of female college students. These findings advance our understanding of the process and mechanism between dispositional mindfulness and mental health, broadened and deepened the understanding of the relationship between dispositional mindfulness and mental health, as well as the mediating role of self-compassion and the moderating role of gender, and offer practical guidance for improving college students’ mental health during the COVID-19 lockdown.
Government innovation subsidy, executives’ academic capital and innovation quality: Evidence from pharmaceutical companies in China
Authors: Xia Yuntian , Fan Min , Zuo Xu , Hao Wenjing , Jia Yiwen
Published: January 2023

The government employs innovation subsidies as a key incentive strategy to promote companies to innovate more technically. This study analyses how innovation subsidies influences the quality of corporate innovation. We create an innovation quality index for pharmaceutical corporations using categorizing data from patent applications submitted by pharmaceutical companies. Using data from 180 listed Chinese pharmaceutical companies between 2010 and 2020, this study proposes a panel regression model to assess the influence of government innovation subsidies on innovation quality, as well as the moderating effect of CEOs’ academic capital. How well innovations are subsidized is also affected by the heterogeneity of property rights. Innovation subsidy has a greater and more positive impact on non-SOEs. This article demonstrates that CEOs with academic credentials and executives with ties to the pharmaceutical industry have a variety of moderate effects. The research offers novel suggestions for enhancing business creativity and the innovation subsidy programme.
Prevalence and correlates of subjective cognitive concerns in Australian university students during the COVID-19 pandemic
Authors: Bird Laura J. , McCabe Melinda , Lim Yen Ying , Cornish Kim
Published: January 2023

Introduction

Coronavirus (COVID-19) instigated unprecedented global effects on healthcare systems, economies, employment, education, travel, and social lives. In addition to increased mental health challenges, pandemic restrictions have triggered emerging cognitive concerns. University students are at particularly high risk of adverse lockdown-related effects, yet despite the substantial adaptions to learning necessitated by COVID-19, limited research has so far focused on the cognitive consequences of the pandemic among university students. This study aimed to comprehensively examine the nature, prevalence, and correlates of subjective cognitive concerns among 972 students (Median age = 22 years, 70% female) enrolled at Monash University, Australia, in December 2020.

Methods

Students completed the online THRIVE@Monash survey, 5 weeks following prolonged lockdown in Melbourne. Using group comparisons and hierarchical binary logistic regression analyses, we examined associations between demographic and enrolment characteristics, COVID-19-related experiences and impacts (author-developed questions), self-reported anxiety and depression symptoms (PROMIS Anxiety and Depression scales), and students’ perceived changes in everyday cognitive functions (author-developed questions).

Results

Over 60% of students reported subjective cognitive concerns (SCCs). After controlling for anxiety and depression symptoms, students reporting more SCCs were more likely to be younger, from White/European ethnic backgrounds, and in their first year of undergraduate study. No differences in SCCs were found between male and female students. Greater worry, anxiety, or stress related to COVID-19 (e.g., infection, leaving the house, hygiene and exposure prevention, impact on physical and mental health), and time spent reading or talking about COVID-19, were generally not associated with SCCs after controlling for anxiety and depression symptoms.

Discussion

These findings highlight vulnerable subgroups of students who might benefit from regular monitoring, education, and interventions to support their cognitive health during the pandemic and beyond. In addition, cognitive concerns may provide additional insight into mental health problems among students, and emphasize the importance of understanding factors that impact students’ long-term academic and career success.
A study on the blended learning effects on students majoring in preschool education in the post-pandemic era: An example of a research-method course in a Chinese university
Authors: Nong Weiguaju , Ye Jian-Hong , Chen Pengfei , Lee Yi-Sang
Published: January 2023

The world has gradually entered the post-pandemic era. Although the pandemic has been slowing down, it still has a strong impact on the education scene. Thus, how to provide students with an effective and flexible learning style is currently an important educational issue. This study focused on the implementation of effective teaching to improve the learning effects based on these special circumstances. To ensure a realistic teaching situation, an experiment of blended learning was conducted in a university in the Guangxi Zhuang Autonomous Region of China for a short-term study, based on the consideration of pandemic supervision and control. In this experiment, a single-group quasi-experimental design method, using the extended O-PIRTATD/S model, was adopted in a research-method course designed for students majoring in preschool education. This research-method course was an 8-week flipped course, where the first 4 weeks were online teaching and the last 4 weeks were taught offline, thus combining as a blended learning course. A total of 115 active participants were recruited for this study. Based on the theoretical framework of the belief-action-outcome (BAO) model, five research hypotheses were proposed with the aim of constructing a learning behavior pattern based on cognitive beliefs which could be verified by structural equation modeling. The results of the study were concluded as follows: 1. Academic self-efficacy had a positive impact on learning engagement, but had a negative impact on cognitive load; 2. Cognitive load did not have a significant impact on learning engagement; 3. Learning engagement had a positive impact on the enhancement of academic self-confidence; and 4. Cognitive load had a negative impact on the enhancement of academic self-confidence.
Children and adolescents’ positive youth development qualities and internet addiction during the COVID-19 pandemic: A longitudinal study in China
Authors: Wang Zhuo , Hong Binxue , Zhang Yanyan , Su Ya , Li Minghui , Zhao Li , Jia Peng
Published: January 2023

Backgrounds

Recent studies have shown that the qualities of children and adolescents’ positive youth development (PYD) enable them to cope with developmental challenges in an adaptive manner and maintain healthy functioning. During the COVID-19 pandemic, there is still a lack of reporting on changes in children and adolescents’ PYD qualities and Internet addiction and their relationship. This study investigated the association between PYD qualities and Internet addiction among the children and adolescents who have experienced the COVID-19 lockdown.

Methods

A school-based cohort survey was launched in December 2019 (Wave 1, before COVID-19 lockdown) and followed up in June 2020 (Wave 2, after COVID-19 lockdown). The Chinese PYD scale (80 items, scoring 80–480) and Young’s Internet addiction test (20 items, scoring 20–100) were used to evaluate the children and adolescents’ PYD qualities and the degree of their Internet addiction, respectively. Cross-sectional regressions, longitudinal regressions, and cross-lagged panel model were used to examine the association between PYD qualities and Internet addiction.

Results

7,985 children and adolescents completed both waves of surveys. Compared with children and adolescents before lockdown (Wave 1), their total PYD quality dropped from 4.99 to 4.96 after COVID-19 lockdown (Wave 2), and the mean score for Internet addiction rose from 35.56 to 36.16. Cross-sectional analysis showed that after controlling for basic characteristics such as age and gender, the total PYD quality of children and adolescents in two waves was negatively correlated with the degree of Internet addiction during the same period, with β of −6.10 and −6.95, respectively. Longitudinal analysis showed that after controlling for basic characteristics, children and adolescents’ total PYD quality in Wave 1 was negatively correlated with the Wave 2 of Internet addiction and the change between the two waves of Internet addiction, with β of −3.35 and −0.26, respectively. Cross-lagged panel models showed a negative bilateral relationship between total PYD quality and Internet addiction.

Conclusion

During the COVID-19 pandemic, the qualities of children and adolescents’ PYD declined, which makes children and adolescents more vulnerable to Internet addiction. Therefore, it is necessary to widely implement programs in China that can comprehensively improve the qualities of children and adolescents’ positive development to prevent Internet addiction, especially after the blockade due to public health emergencies.
Imaging oxidative stress in brains of chronic methamphetamine users: A combined 1H-magnetic resonance spectroscopy and peripheral blood biomarker study
Authors: Watling Sarah E. , Jagasar Samantha , McCluskey Tina , Warsh Jerry , Rhind Shawn G. , Truong Peter , Chavez Sofia , Houle Sylvain , Tong Junchao , Kish Stephen J. , Boileau Isabelle
Published: January 2023

Introduction

Preclinical data suggest methamphetamine (MA), a widely used stimulant drug, can harm the brain by causing oxidative stress and inflammation, but only limited information is available in humans. We tested the hypothesis that levels of glutathione (GSH), a major antioxidant, would be lower in the brains of chronic human MA preferring polysubstance users. We also explored if concentrations of peripheral immunoinflammatory blood biomarkers were related with brain GSH concentrations.

Methods

20 healthy controls (HC) (33 years; 11 M) and 14 MA users (40 years; 9 M) completed a magnetic resonance spectroscopy (MRS) scan, with GSH spectra obtained by the interleaved J-difference editing MEGA-PRESS method in anterior cingulate cortex (ACC) and left dorsolateral prefrontal cortex (DLPFC). Peripheral blood samples were drawn for measurements of immunoinflammatory biomarkers. Independent samples t-tests evaluated MA vs. HC differences in GSH.

Results

GSH levels did not differ between HC and MA users (ACC p = 0.30; DLPFC p = 0.85). A total of 17 of 25 immunoinflammatory biomarkers were significantly elevated in MA users and matrix metalloproteinase (MMP)-2 (r = 0.577, p = 0.039), myeloperoxidase (MPO) (r = –0.556, p = 0.049), and MMP-9 (r = 0.660, p = 0.038) were correlated with brain levels of GSH.

Conclusion

Normal brain GSH in living brain of chronic MA users is consistent with our previous postmortem brain finding and suggests that any oxidative stress caused by MA, at the doses used by our participants, might not be sufficient to cause either a compensatory increase in, or substantial overutilization of, this antioxidant. Additionally, more research is required to understand how oxidative stress and inflammatory processes are related and potentially dysregulated in MA use.
Does self-medication reduce medical expenditure among the middle-aged and elderly population? A four-wave longitudinal study in China
Authors: Zheng Zehao , Feng Zhanchun , Zhang Donglan , Sun Xiaobo , Dong Dong , Luo Youxi , Feng Da
Published: January 2023

Introduction

Self-medication has a high prevalence in the middle-aged and elderly population in China. Despite the published evidence demonstrating the economic benefits of self-medication, limited research has addressed the relationship between self-medication and individual medical expenditures, especially within the Chinese population. This study examined the effect of self-medication on individual medical expenditures in China and analyzed the heterogeneity between outpatient and inpatient cases.

Methods

We conducted a panel data analysis using data from four waves of the China Health and Retirement Longitudinal Study (CHARLS). Two-part mixed-effect models were implemented to estimate the effect of self-medication on total outpatient and inpatient expenses and out-of-pocket (OOP) costs, where mixed-effects logit regression was used as the first part, and generalized linear mixed models with log link and gamma distribution was used as the second part.

Results

We identified 72,041 responses representing 24,641 individuals, of which 13,185 responses incurred outpatient expenses and 9,003 responses incurred inpatient costs. Controlling for all covariates, we found that self-medication behaviors were significantly associated with a higher probability of outpatient service utilization (OR = 1.250, 95% CI = 0.179 to 0.269; P < 0.001), but displayed no significant association with outpatient expenses. Respondents who had taken self-medication were less likely to use inpatient services (OR = 0.865, 95% CI = −0.201 to −0.089; P < 0.001), and their inpatient expenses were significantly reduced by 9.4% (P < 0.001). Inpatient OOP costs were significantly reduced by 10.7% (P < 0.001), and outpatient OOP costs were significantly increased by 11.3% (P < 0.001) among respondents who had self-medicated.

Conclusions

This study allowed us to identify the economic value of self-medication among the middle-aged and elderly population in China. Future work should guide the middle-aged and elderly to take responsible self-medication to reduce their economic burden.
Using online social networks to provide a parental health-education intervention for preventing unintentional injuries among children aged 0–3 years: A randomized controlled trial and social network analysis in Shanghai, China
Authors: Feng Yuheng , Li Xiaohong , Ma Xueqi , Zhu Zhixu , Chen Kaiyue , Gao Jun , Xia Jingwei , Jiang Ruo , Lu Jun
Published: January 2023

Introduction

Unintentional injury among children represents a major public health problem. Online-social-network-based parental-health-education is a potential way to reduce child unintentional injuries. The study aimed to explore the mechanisms by which online-social-network-based health education may reduce the unintentional injuries among children aged 0–3 years.

Methods

We conducted a participant-blinded, randomized controlled, online-social-network-based health-education intervention study from March 2019 to February 2020 in Shanghai. We established four WeChat groups (two intervention groups and two control groups). For the intervention groups, a doctor's assistant regularly delivered information regarding unintentional injuries among children, and community childcare doctors answered parents' questions concerning their children's health, including unintentional injuries. Meanwhile, the control groups did not receive any information from the assistant. The study selected one intervention group and one control group and compared the ego network and whole network indicators to determine the differences between the intervention and control groups.

Results

In the intervention and control groups, 64.5% and 31.9% of the members, respectively, engaged in communication, and 1,736 and 273 records, respectively, were obtained. Regarding ego network, the doctor showed the largest network in the intervention group, and the size of the intervention group's network was twice that of the control group; the number of ties in the intervention group was nine times that of the control group. Fourteen and four parents in the intervention and control group played an active role, respectively. Regarding centrality, all WeChat groups were loose and multiple centers existed. Regarding subgroup cohesion, the intervention group had 28 cliques with 27 members, and the control group had 4 cliques with 4 members. For structural hole, 23.7% and 7.5% members in the intervention and control group actively participated in interactions, respectively, having strong control and influence over other parents; 69.2% and 59.1% members in the intervention and control group, respectively, had values of < 1.000, showing that they had strong ability to cross-jump structural holes.

Discussion

Online-social-networks-based health education interventions could enhance communication among parents, and between parents and community childcare doctors, and also shorten the social distance between them. Thus, online-social-network-based parental-health-education-intervention can be a feasible and generalizable means of preventing unintentional injuries among children.
A cross-sectional study evaluating health-related quality of life of Chinese pediatric patients with hematological malignancies using EQ-5D-Y
Authors: Sun Yue , Zhou Hui-Jun , Shen Anle , Wu Bin , Wang Wei , Luo Nan , Wang Pei
Published: January 2023

Background

The study aimed to assess health-related quality of life (HRQoL) and to estimate the health utility of pediatric patients with hematological malignancies (HMs) in China.

Method

A cross-sectional study recruited a series of pediatric inpatients diagnosed with HM from November 2018 to May 2019 in the Shanghai Children's Medical Center. Subjects were interviewed to collect sociodemographic information about themselves and their guardians. The EQ-5D-Y was completed by each patient to rate their own HRQoL, which later derived the health utility. The health status was also assessed by clinicians following the Eastern Cooperative Oncology Group (ECOG) system. Upon the descriptive analysis and univariate analysis, multivariate generalized linear models were built to explore the associations of risk factors with HRQoL measures of utility, Visual Analog Scale (VAS) score, and the five EQ-5D-Y domains.

Results

The 96 subjects had a mean age of 10.5 years and included 62 (64.4%) boys. There were 46 (47.9%) and 25 (26.0%) children diagnosed with acute lymphoblastic leukemia and non-Hodgkin's lymphoma, respectively. The means (SD) of utility and EQ-VAS scores were 0.88 (0.10) and 85.8 (15.1), respectively. Twenty-six (27.1%) patients were graded poor health by the ECOG standard (score 2/3). Both univariate and multivariate analyses found strong correlations between ECOG and HRQoL. After adjusting for covariates, poor ECOG score was significantly associated with an impaired utility and VAS of −0.103 and −8.65, respectively. With regard to individual HRQoL domains, worse ECOG was more likely to report health problems with an increased risk of 2.94 to 12.50; residence, income, guardians' education, and disease duration were also found to be significantly related to either the utility or certain health domains.

Conclusion

The HRQoL of Chinese pediatric patients with HM is considered relatively poor and of great concern to healthcare. With the strong correlations between EQ-5D-Y-related HRQoL measures and the traditional clinical index ECOG, the EQ-5D-Y is able to provide valuable evidence for clinical decision-making at the individual level. At the same time, its health utility can inform resource allocation at a macro level.
A comparison of emotional wellbeing and burnout of primary care professionals in 2014 and 2021
Authors: Abad Alejandro , Fuentes Araceli , Paredes Eugeni , Godoy Sofia , Perera Sara , Yuguero Oriol
Published: January 2023

Background

Due to the pandemic that started in February–March 2020 and after many years of economic restrictions suffered by our health system, the levels of stress, exhaustion and suffering among health workers has increased.

Objective

Our study aims to perform a comparative analysis of the degree of burnout and emotional wellbeing among health professionals between 2014 and 2021.

Methods

This is a comparative descriptive study of two cohorts of primary care professionals of the Lleida health region (SPAIN). We have one cohort from 2014 and another from 2021 with the same selection criteria. Burnout was assessed using the Maslach Burnout Inventory (MBI-HSS) test. Gender, age, professional category and work environment were also evaluated.

Results

We obtained a response rate in 2014 of 52.7% (n = 267) and of 41.4% (n = 217) in 2021 with similar sociodemographic characteristics. There are significant differences (p < 0.001) in the three categories of burnout. The high scores for emotional exhaustion and depersonalization have increased, rising between 2014 and 2021 from 23.2 to 60.8% and from 12.4 to 42.4%, respectively. However, there is also a significant increase in high personal accomplishment, rising from 9.0% in 2014 to 26.7%. We have also detected differences depending on age and professional role.

Conclusion

This study shows worsening burnout levels of primary care professionals in our region, specifically emotional exhaustion and depersonalization. However, it also shows that during the pandemic, personal accomplishment was reinforced.
Racial inequality in COVID-treatment and in-hospital length of stay in the US over time
Authors: Althouse Benjamin M. , Baker Charlotte , Smits Peter D. , Gratzl Samuel , Lee Ryan H. , Goodwin Cartwright Brianna M. , Simonov Michael , Wang Michael D. , Stucky Nicholas L.
Published: January 2023

Introduction

Demonstrated health inequalities persist in the United States. SARS-CoV-2 (COVID) has been no exception, with access to treatment and hospitalization differing across race or ethnic groups. Here, we aim to assess differences in treatment with remdesivir and hospital length of stay across the four waves of the pandemic.

Materials and methods

Using a subset of the Truveta data, we examine the odds ratio (OR) of in-hospital remdesivir treatment and risk ratio (RR) of in-hospital length of stay between Black or African American (Black) to White patients. We adjusted for confounding factors, such as age, sex, and comorbidity status.

Results

There were statistically significant lower rates of remdesivir treatment and longer in-hospital length of stay comparing Black patients to White patients early in the pandemic (OR for treatment: 0.88, 95% confidence interval [CI]: 0.80, 0.96; RR for length of stay: 1.17, CI: 1.06, 1.21). Rates became close to parity between groups as the pandemic progressed.

Conclusion

While inpatient remdesivir treatment rates increased and length of stay decreased over the beginning course of the pandemic, there are still inequalities in patient care.
Multimorbidity patterns in South Africa: A latent class analysis
Authors: Roomaney Rifqah Abeeda , van Wyk Brian , Cois Annibale , Pillay van-Wyk Victoria
Published: January 2023

Introduction

South Africa has the largest burden of HIV worldwide and has a growing burden of non-communicable diseases; the combination of which may lead to diseases clustering in ways that are not seen in other regions. This study sought to identify common disease classes and sociodemographic and lifestyle factors associated with each disease class.

Methods

Data were analyzed from the South African Demographic and Health Survey 2016. A latent class analysis (LCA) was conducted using nine disease conditions. Sociodemographic and behavioral factors associated with each disease cluster were explored. All analysis was conducted in Stata 15 and the LCA Stata plugin was used to conduct the latent class and regression analysis.

Results

Multimorbid participants were included (n = 2 368). Four disease classes were identified: (1) HIV, Hypertension and Anemia (comprising 39.4% of the multimorbid population), (2) Anemia and Hypertension (23.7%), (3) Cardiovascular-related (19.9%) and (4) Diabetes and Hypertension (17.0%). Age, sex, and lifestyle risk factors were associated with class membership. In terms of age, with older adults were less likely to belong to the first class (HIV, Hypertension and Anemia). Males were more likely to belong to Class 2 (Anemia and Hypertension) and Class 4 (Diabetes and Hypertension). In terms of alcohol consumption, those that consumed alcohol were less likely to belong to Class 4 (Diabetes and Hypertension). Current smokers were more likely to belong to Class 3 (Cardiovascular-related). People with a higher body mass index tended to belong to Class 3 (Cardiovascular-related) or the Class 4 (Diabetes and Hypertension).

Conclusion

This study affirmed that integrated care is urgently needed, evidenced by the largest disease class being an overlap of chronic infectious diseases and non-communicable diseases. This study also highlighted the need for hypertension to be addressed. Tackling the risk factors associated with hypertension could avert an epidemic of multimorbidity.
Community health worker insights on promoting research engagement with diverse populations
Authors: Killough Cynthia M. , Madaras Annemarie , Phillips Christina , Hettema Jennifer , Ceballos Venice , Fuentes Jesus E. , Rishel Brakey Heidi , Wagner Katherine , Page Kimberly
Published: January 2023

Representation of diverse populations in health research enhances our ability to understand the factors that impact health, generalize results, implement findings, and promote social justice. The primary objective of the study was to understand the unique perspectives of frontline community health workers (CHWs) to identify actionable barriers and facilitators that may impact representation of diverse groups in health research. Focus groups with CHWs were conducted followed by thematic analysis. Results revealed five main themes: barriers/risks to research participation, facilitation of research, CHW roles, recommendations, and transparency. A novel finding was that some CHWs see themselves as both facilitators and gatekeepers. As facilitators, CHWs ensure their patient populations receive resources and benefit from being involved in research; as gatekeepers CHWs feel that they protect patient populations from experiencing further trauma, especially when engaging in research. Recognizing that in many communities there is a high reliance and trust with CHWs, can promote genuine and informed participation at all stages of research.
Drug fever induced by antibiotics of β-lactams in a patient after posterior cervical spine surgery—A case report and literature review
Authors: Hu Yunxiang , Han Jun , Gao Lin , Liu Sanmao , Wang Hong
Published: January 2023

Drug fever is a febrile reaction that emerges temporarily with the administration of a drug or a variety of drugs and disappears after cessation of the targeting agent. There are a few previous reports about drug fever, but they pertain mainly to patients accompanied by no surgical intervention. Based on the literature reviewed, drug fever in patients after posterior cervical spine surgery has never been mentioned before; therefore, we present a 56-year-old man diagnosed with drug fever after posterior cervical spine surgery for traumatic cervical myelopathy. Fortunately, his body temperature rapidly came down in 2 days after discontinuing the antibiotics. He was discharged after two more days of observation, and the patient recovered well without any further complaints. Early diagnosis of drug fever may greatly reduce inappropriate and potentially detrimental diagnostic and therapeutic interventions. For patients with persistent fever, if it happened days after surgery, particularly when it is without any infectious evidence, then it is necessarily important to consider a possible reason of drug-induced fever.
Successful treatment of thoracic myelopathy caused by spontaneous spinal epidural hematoma (SSEH) combined with calcification of the ligamentum flavum (CLF) by posterior percutaneous endoscopic surgery (PPES): A case report
Authors: Lisheng Hou , Dong Zhang , Xuedong Bai , Jinglei Shi , Shaokui Nan , Tianjun Gao , Feng Ge , Qing He
Published: January 2023

Study Design

A retrospective case report.

Objective

To report a case who developed deteriorated paraplegia by spontaneous spinal epidural hematoma (SSEH) based on calcification of the ligamentum flavum (CLF) at the T10–11 level, achieved full neurological recovery following posterior percutaneous endoscopic surgery (PPES).

Summary of Background Data

CLF rarely occurs at the thoracic spine, and the symptom usually progress slowly. SSEH is another rare spinal lesion that might progress rapidly and cause emergent severe spinal cord compression syndrome. Coexistence of SSEH and CLF at the same thoracic level was rarely reported in English literature.

Methods

A 65-year-old man presented to our hospital with the complaint of sensorimotor loss on the lower limbs and dysfunction of bladder for 1 day after a progressive weakness and numbness of the lower limbs for 3 months. MR examination found a dorsal protruding mass at the T10–11 level, while computed tomography (CT) found the protruding mass contained scattered calcified deposits. The patient was diagnosed with thoracic CLF. Decompression via PPES was carried out to realize bilateral decompression through a unilateral approach.

Results

During the operation, the protruding mass was found to be composed of SSEH and CLF together. After the operation, the patient's neurological function recovered quickly. One week later, the patient could walk by himself. After 3 months, complete neurological function had recovered.

Conclusion

SSEH could develop based on CLF at thoracic level and cause serious neurological dysfunction. PPES might be an advisable method to remove CLF and evacuate SSEH with good clinical results.
scMODD: A model-driven algorithm for doublet identification in single-cell RNA-sequencing data
Authors: Zhao Xinye , Du Alexander , Qiu Peng
Published: January 2023

Single-cell RNA sequencing (scRNA-seq) data often contain doublets, where a doublet manifests as 1 cell barcode that corresponds to combined gene expression of two or more cells. Existence of doublets can lead to spurious biological interpretations. Here, we present single-cell MOdel-driven Doublet Detection (scMODD), a model-driven algorithm to detect doublets in scRNA-seq data. ScMODD achieved similar performance compared to existing doublet detection algorithms which are primarily data-driven, showing the promise of model-driven approach for doublet detection. When implementing scMODD in simulated and real scRNA-seq data, we tested both the negative binomial (NB) model and the zero-inflated negative binomial (ZINB) model to serve as the underlying statistical model for scRNA-seq count data, and observed that incorporating zero inflation did not improve detection performance, suggesting that consideration of zero inflation is not necessary in the context of doublet detection in scRNA-seq.
Complete genome analysis of the African swine fever virus isolated from a wild boar responsible for the first viral outbreak in Korea, 2019
Authors: Kim Garam , Park Jung-Eun , Kim So-Jeong , Kim Yeonji , Kim Wonjun , Kim Yong-Kwan , Jheong WeonHwa
Published: January 2023

African swine fever (ASF), a highly contagious and severe hemorrhagic viral disease in swine, is emerging as a major threat not only in Korea but also worldwide. The first confirmed case of ASF in Korea was reported in 2019. Despite the occurrence of ASF in Korea, only a few studies have genetically characterized the causative ASF virus (ASFV). In this study, we aimed to genetically characterize the ASFV responsible for the 2019 outbreak in Korea. The genome of the ASFV isolated during the first outbreak in Korea was analyzed. The Korea/YC1/2019 strain has 188,950 base pairs, with a GC content of 38.4%. The complete genome sequence was compared with other ASFV genomes annotated in the NCBI database. The Korea/YC1/2019 strain shared the highest similarity with Georgia 2007, Belgium 2018/1, and ASFV-wbBS01 strains. This study expands our knowledge of the genetic diversity of ASFV, providing valuable information for epidemiology, diagnostics, therapies, and vaccine development.
The Effect of the Knowledge Management Processes Capability on Innovation Activities in the Mexican Industry
Authors: Flores López José Guadalupe , Jacobo Hernández Carlos Armando , Leyva Osuna Beatriz Alicia , Limón Valencia Luis Alberto
Published: January 2023

Mexican industrial organizations focus their efforts on the development of new products and processes, including breakthrough technology. Few studies have focused on the analysis of this corporate effort. After an in-depth theoretical review, it has been detected that most of the research has been based on the study of knowledge management along its dimensions, and there has been no research that incorporates the capabilities of the knowledge management process and its effect on two activities that generate innovation. With the application of a Likert scale-type instrument to 279 industrial companies in Mexico, it was detected that there is a relationship and influence between the dimensions of knowledge acquisition (KAC), knowledge updating (KUP), knowledge protection (KP), knowledge conversion (KC) and knowledge application (KAP) in innovation-generating activities, such as research and development (R&D) and technology acquisition (TA). This was analyzed by the partial least squares (PLS) structural equation technique. Finally, it is important to highlight the contribution that the results of the study have in possible future research that can be carried out, for example, the analysis of the protection of knowledge and its impact on the industry of other countries.
A Method of Polished Rice Image Segmentation Based on YO-LACTS for Quality Detection
Authors: Zhou Jinbo , Zeng Shan , Chen Yulong , Kang Zhen , Li Hao , Sheng Zhongyin
Published: January 2023

The problem of small and multi-object polished rice image segmentation has always been one of importance and difficulty in the field of image segmentation. In the appearance quality detection of polished rice, image segmentation is a crucial part, directly affecting the results of follow-up physicochemical indicators. To avoid leak detection and inaccuracy in image segmentation qualifying polished rice, this paper proposes a new image segmentation method (YO-LACTS), combining YOLOv5 with YOLACT. We tested the YOLOv5-based object detection network, to extract Regions of Interest (RoI) from the whole image of the polished rice, in order to reduce the image complexity and maximize the target feature difference. We refined the segmentation of the RoI image by establishing the instance segmentation network YOLACT, and we eventually procured the outcome by merging the RoI. Compared to other algorithms based on polished rice datasets, this constructed method was shown to present the image segmentation, enabling researchers to evaluate polished rice satisfactorily.
Date-Palm Compost as Soilless Substrate Improves Plant Growth, Photosynthesis, Yield and Phytochemical Quality of Greenhouse Melon (Cucumis melo L.)
Authors: Aydi Samir , Sassi Aydi Sameh , Rahmani Rami , Bouaziz Faten , Souchard Jean Pierre , Merah Othmane , Abdelly Chedly
Published: January 2023

The selection of adequate substrate for soilless culture is based on technical and economic considerations. Therefore, the search for alternatives by the valorization of natural by-products is gaining importance. The main objective of this study was to compare the effects of local farm resources, date-palm waste, as culture substrate, to coconut fiber (CF) (commonly used in soilless culture) on melon (Cucumis melo L.) plant growth, water relations, photosynthesis, chlorophyll fluorescence as well as phytochemical analysis under hydroponics culture system. Two growing substrates were tested: the compost of date palm waste added to animal manure (7:3 w w−1) (DPAM) and the date palm trunk compost (DPT). Coconut fiber and soil were used as positive and negative controls, respectively, in randomized blocks. Results showed that the vegetative growth was improved under DPT and CF substrates while CF substrate enhanced fruit yield and phytochemical properties: Total soluble solids TSS (% Brix), total dissolved solutes (TDS); Titratable acidity (as citric acid); Sugar content and juice pH of melon fruit. Date-palm waste-based substrates enhanced the vegetative growth and the fruit yield of melon as compared to soil-based culture. It seems that date palm waste-based substrates, especially trunk compost, could be promising and cheaper alternatives compared to coconut fiber substrates commonly used in Tunisia in soilless cultures.