bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the clinical spectrum of relapsing polychondritis: insights into its pathogenesis, novel monogenic causes, and therapeutic strategies
Authors: Bica Blanca E R G , de Souza Alexandre Wagner S , Pereira Ivânio Alves
Published: April 2024

Relapsing polychondritis is a rare multisystem disease involving cartilaginous and proteoglycan-rich structures. The diagnosis of this disease is mainly suggested by the presence of flares of inflammation of the cartilage, particularly in the ears, nose or respiratory tract, and more rarely, in the presence of other manifestations. The spectrum of clinical presentations may vary from intermittent episodes of painful and often disfiguring auricular and nasal chondritis to an occasional organ or even life-threatening manifestations such as lower airway collapse. There is a lack of awareness about this disease is mainly due to its rarity. In 2020, VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, a novel autoinflammatory syndrome, was described. VEXAS syndrome is attributed to somatic mutations in methionine-41 of UBA1, the major E1 enzyme that initiates ubiquitylation. This new disease entity connects seemingly unrelated conditions: systemic inflammatory syndromes (relapsing chondritis, Sweet’s syndrome, and neutrophilic dermatosis) and hematologic disorders (myelodysplastic syndrome or multiple myeloma). Therefore, this article reviews the current literature on both disease entities.
Hemophagocytic lymphohistiocytosis and macrophage activation syndrome: two rare sides of the same devastating coin
Authors: Sztajnbok Flavio , Fonseca Adriana Rodrigues , Campos Leonardo Rodrigues , Lino Kátia , Rodrigues Marta Cristine Félix , Silva Rodrigo Moulin , de Almeida Rozana Gasparello , Perazzio Sandro Félix , Carvalho Margarida de Fátima Fernandes
Published: April 2024

Hemophagocytic lymphohistiocytosis (HLH) is a rare genetic hyperinflammatory syndrome that occurs early in life. Macrophage activation syndrome (MAS) usually refers to a secondary form of HLH associated with autoimmunity, although there are other causes of secondary HLH, such as infections and malignancy. In this article, we reviewed the concepts, epidemiology, clinical and laboratory features, diagnosis, differential diagnosis, prognosis, and treatment of HLH and MAS. We also reviewed the presence of MAS in the most common autoimmune diseases that affect children. Both are severe diseases that require prompt diagnosis and treatment to avoid morbidity and mortality.
Association between genetic polymorphisms and other attributing factors with lipid profiles among statin users: a cross-sectional retrospective study
Authors: Shamsudin Amirul Faez , Sulong Sarina , Ahmad Imran , Bakar Nur Salwani
Published: April 2024

Background

Statins are well known for their efficacy to improve lipid profiles. Their efficacy varies between individuals and can be modified by patient factors such as genetic polymorphisms. This study used a cross-sectional retrospective design to assess the effect of selected single nucleotide polymorphisms (SNPs) and other patient-specific clinical variables on statin-related lipid profile changes in a subgroup of Malaysians. The impact of low and moderate intensity of statin doses (10–40 mg/day for at least six weeks), regardless of statin types, was assessed between SNPs of previously identified genes with clinical relation to statin efficacy and lipid profile changes before (baseline) and after statin treatment; two ranges of treatment durations, i.e. ≤ 6 months and 7–12 months. DNA was extracted from patient's venous blood (3 mL), and SNP genotyping was performed using PCR–RFLP method. Using a dominant genetic model, the association between selected SNPs from six genes of interest (ABCG2,ABCC2,APOE,APOA5,GATMandCOQ2) and the patients' lipid profiles was investigated.

Results

A total of 229 statin-treated patients were included. The mean age of the patients was 53 ± 7.16 years, and they were mostly females (53.3%), Malay (96.1%), and were taking atorvastatin and simvastatin (90.4%). Seven SNPs genotyped from six genes investigated were related to different lipid profile before and after statin treatment. At baseline,ABCG2rs2231142 (P = 0.035) andAPOA5rs662799 (P = 0.007) variants had higher HDL-c levels, whileABCC2rs717620 variants had higher TC (P = 0.040) and LDL-c levels (P = 0.022). Following statin treatment,ABCC2rs717620 (lower TG,P = 0.009) andAPOA5rs662799 (higher HDL,P = 0.031; lower TG,P = 0.037) were associated with improved lipid profiles, with the association being substantially related to males carrying minor alleles of the SNPs. None of the investigated SNPs were related to significant statin-related LDL-c lowering effects during statin therapy.

Conclusion

To better understand inter-individual heterogeneity in lipid profiles during statin therapy, it would be helpful to take patient genetics and gender into consideration before and after administering statins.
Overcoming tight perihilar malignant biliary obstructions during percutaneous biliary intervention in Nigerian patients: case reports
Authors: Ninalowo Hammed A. , Adenigba Peter T. , Oluyemi Aderemi O.
Published: April 2024

Background

A major challenge of either endoscopic or percutaneous approach to placing palliative biliary stents is the difficulty in traversing tight perihilar malignant obstructions. This can be overcome with a rendezvous approach (combined endoscopic retrograde cholangiopancreatography (ERCP)/percutaneous approach) or may require initial placement of an external drain and reattempting later. Interventional radiology for biliary obstruction is still in infant days in our locality. Herein, we describe two cases of perihilar malignant biliary obstruction (MBO) managed at a private facility in Lagos, Nigeria, in which we had to come up with a creative approach to crossing these tight junctions in the absence of ERCP facilities. This was done by securing percutaneous retrograde access into the common bile duct and combining it with the initially unsuccessful anterograde approach. In both cases, this combined percutaneous anterograde/retrograde approach resulted in successful traversal of the malignant obstruction and placement of internal biliary stents.

Case presentation

We present the case of two elderly patients with tight malignant biliary obstruction (MBO), one from a suspected cholangiocarcinoma and the other from hepatic metastatic colorectal carcinoma. Both patients had successful traversal of the obstruction via a combined percutaneous anterograde/retrograde approach and biliary stenting.

Conclusions

Our case reports demonstrate an unusual approach that should assist interventional radiologists in resource-limited setting who seek for a viable option to those presently available for traversing perihilar MBOs in the percutaneous placement of internal stents.
Comparison of Repeat Versus Initial Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: A Retrospective Multicenter Matched Cohort Study
Authors: Orrego Gonzalez Eduardo , Mantziaris Georgios , Shaaban Ahmed , Starke Robert M. , Ding Dale , Lee John Y. K. , Mathieu David , Kondziolka Douglas , Feliciano Caleb , Grills Inga S. , Barnett Gene H. , Lunsford L. Dade , Liščák Roman , Lee Cheng-chia , Martinez Álvarez Roberto , Peker Selcuk , Samanci Yavuz , Cockroft Kevin M. , Tripathi Manjul , Palmer Joshua D. , Zada Gabriel , Cifarelli Christopher P. , Nabeel Ahmed M. , Pikis Stylianos , Sheehan Jason P.
Published: April 2024

BACKGROUND AND OBJECTIVES:

Studies comparing neurological and radiographic outcomes of repeat to initial stereotactic radiosurgery (SRS) intracranial arteriovenous malformations are scarce. Our aim was to perform a retrospective matched comparison of patients initially treated with SRS with those undergoing a second radiosurgical procedure.

METHODS:

We collected data from arteriovenous malformations managed in 21 centers that underwent initial and repeated radiosurgery from 1987 to 2022. Based on arteriovenous malformations volume, margin dose, deep venous drainage, deep, and critical location, we matched 1:1 patients who underwent an initial SRS for treatment-naive arteriovenous malformations and a group with repeated SRS treatment.

RESULTS:

After the selection process, our sample consisted of 328 patients in each group. Obliteration in the initial SRs group was 35.8% at 3 and 56.7% at 5 years post-SRS, while the repeat SRS group showed obliteration rates of 33.9% at 3 years and 58.6% at 5 years, without statistically significant differences (P = .75 and P = .88, respectively). There were no statistically significant differences between the 2 groups for obliteration rates (hazard ratio = 0.93; 95% CI, 0.77-1.13; P = .5), overall radiation-induced changes (RIC) (OR = 1.1; 95% CI, 0.75-1.6; P = .6), symptomatic RIC (OR = 0.78; 95% CI, 0.4-1.5; P = .4), and post-SRS hemorrhage (OR = 0.68; 95% CI; P = .3).

CONCLUSION:

In matched cohort analysis, a second SRS provides comparable outcomes in obliteration and RIC compared with the initial SRS. Dose reduction on repeat SRS may not be warranted.
Por uma epistemologia da espontaneidade: uma reflexão sobre o lugar do psicodrama nas matrizes do pensamento psicológico.
Authors: Lima Daniel Mattos , Paiva Selênia Feitosa
Published: April 2024

O objetivo deste artigo é refletir sobre os aspectos epistemológicos do Psicodrama de Jacob Levy Moreno (1889-1974). Por meio das matrizes do pensamento psicológico sistematizadas por Luis Claudio Figueiredo, efetuar-se-á uma reflexão sobre o conceito de espontaneidade, buscando entender em que medida a espontaneidade rompe com o atomicismo e o mecanicismo e com o modelo de ciência do Iluminismo, articulando-se com o Romantismo. Por fim, situar-se-á o Psicodrama dentro da matriz fenomenológica e existencialista.
Impacto das redes sociais na alimentação
Authors: Machado Richele Janaína , Cristina Rocha Daianne , Carvalho Cavaleiro de Macêdo Letícia
Published: April 2024

A ascensão da internet representou uma revolução na comunicação global, encurtando distâncias e proporcionando acesso instantâneo à informação em escala global. Apesar de seus benefícios na democratização da informação, a internet também trouxe implicações negativas, notadamente na saúde mental. O uso excessivo das redes sociais está associado à ansiedade, à depressão e a distúrbios alimentares, especialmente entre os jovens. Essa exposição constante a vidas digitalmente idealizadas pode desencadear sentimentos de inadequação e baixa autoestima. Além disso, a internet normalizou práticas prejudiciais à alimentação, como restrição alimentar excessiva e medo do ganho de peso, aumentando o risco de transtornos alimentares, como Anorexia Nervosa e Bulimia Nervosa. Nesse contexto, profissionais de nutrição desempenham um papel crucial na prevenção e no acompanhamento nutricional de pacientes com transtornos alimentares.
The Archival Ucrainica: institutionalization of research
Authors: Matâš Ìrina
Published: April 2024

The article shows the development and nature of the concept “Archival Ucrainicaˮ, the process of its introduction into scholarly and public circulation, and maps the process of institutionalization of archival Ukrainian studies as a field of archival and source studies. The history of the development of the concept is related to the period of state formation during the Ukrainian Revolution of 1917–1921. The presence of the term “Ucrainicaˮ in the library sphere, as opposed to the archival sphere, is pointed out, as well as the beginning of practical activities of archivists in the return of documents of Ukrainian origin forcibly removed from Russia. The article also presents the formation of the legal basis for the identification, registration and return of archival Ukrainian literature after the restoration of Ukraine's state independence. The text outlines the factors that led to the emergence of Ukrainian archival research: connected with worldview, which guided Ukrainian society toward a non-binding understanding of history and created the need to expand the source base of Ukrainian studies; connected with research, which, against the backdrop of overcoming the artificial limitations of certain fields of archaeology, archival science, sources, historical research and the active formation of the information society, stimulated the development of the concept of creating an information system that would collect information on Ukrainian archival documents; cultural, which realized the need for the spiritual revival of Ukrainians, who had long remained inthe shadow of ideological restrictions, and the establishment of effective scientific and creative contacts with Ukrainians abroad. Attention was paid to the activities of the Main Archival Board of Ukraine, the Central State Archives of Foreign Ucrainica, the Ukrainian Research Institute of Archival and Documentary Studies, and the role of Hennadiy Boriak in the development of Ukrainian archival science was shown. The article also highlights the problems of practical implementation of the tasks of identifying, registering and returning to Ukraine documents of Ukrainian origin.
Seminarium szkoleniowe Sekcji Archiwów Instytucji Naukowych i Kulturalnych SAP. Zielona Góra, 13–15 września 2023 r.
Authors: Degen Robert
Published: April 2024

Sprawozdanie z seminarium szkoleniowego Sekcji Archiwów Instytucji Naukowych i Kulturalnych SAP, które odbyło się w Zielonej Górze, w dniach 13 – 15 września 2023 r. i obradowało pt. „Problemy wartościowania dokumentacji – teoria i praktyka. A co z wartością archiwisty?”
History and Contents of the Archive of the Sandomierz College of Canons in the Light of the second volume of Feliks Kiryk’s Inwentarz Rękopisów Archiwum Kapituły Kolegiackiej i Katedralnej w Sandomierzu
Authors: Szczerba Michał , Aldridge Mark
Published: April 2024

Presentation of two volumes of the Inventory of the manuscripts of the Sandomierz Collegiate and Cathedral Chapter Archives, prepared by Feliks Kiryk and published in 2010 and 2018, which at the same time became an attempt to show the holdings of the institution in Sandomierz
Interdisciplinary Investigations at the Intersection of Philosophy and Translation Studies
Authors: Makurat-Snuzik Hanna
Published: April 2024

This article provides an overview of the challenges faced at the intersection of philosophy and translation studies. The interdisciplinary scope under consideration covers philosophical contributions to theoretical investigation of translation, which are substantively grounded in the experiences of practicing translators, amongst whom are philosophers. Furthermore, the paper emphasizes the prominent role of philosophy in establishing the fundamental conditions and concepts of translation, and addresses the numerous philosophical approaches contributing to the interdisciplinary discourse on the nature of translation. Considerable attention is given to metaphysical and epistemological points that seem to play a significant role in conceptualising translation issues and establishing the theoretical foundations of translation studies, as well as in providing a deeper insight into the translation process. On the whole, the philosophisation of the translation phenomenon contributes to the substantial growth of both philosophical thought and translation studies.
Tłumaczenie eksperymentu – dwa wiersze Daniiła Charmsa w przekładzie Wiktora Woroszylskiego
Authors: Bednarczyk Anna
Published: April 2024

TRANSLATION OF THE EXPERIMENT – TWO POEMS BY DANIIL KHARMS TRANSLATED BY WIKTOR WOROSZYLSKI
The article concerns two poems by Daniil Kharms (Нéтеперь and Фадеев, Калдеев и Пепермалдеев…) translated by Wiktor Woroszylski (Nieteraz and Fadiejew, Kałdiejew i Piepiermałdiejew…). This translation was considered in the context of a poetic experiment used by the Russian author. On the one hand, free verse (Nieteraz) and on the other hand, accentual-syllabic verse (Fadiejew…) were compared to their translations. Irrespective of the form, both the striving to reproduce the absurdity characteristic of Kharms and smoothing out the non-normative punctuation of the original can be noticed in Woroszylski’s translations. In addition to the conclusions regarding the decision of a particular translator, attention was also drawn to the need of taking into account the characteristics of a given text (experiment and absurdity) and the relationship between the translation and the literature in a given period of time.
Etyka tłumaczy ustnych języków fonicznych i tłumaczy języków migowych
Authors: Biernacka Agnieszka , Kalata-Zawłocka Aleksandra
Published: April 2024

ETHICS OF SPOKEN AND SIGNED LANGUAGE INTERPRETERS: FROM THEORETICAL CONSIDERATIONS TO PRACTICAL SOLUTIONS
Codes of ethics are readily developed by professional associations and institutions for interpreter education and training. The codes may be local, national or international, may apply to different interpreting environments (medical, legal and judicial, educational, etc.) and to different languages: spoken and signed. There are several types of documents used by different groups of interpreters. The subject of this discussion is two codes created by individual professional organisations: The Professional Code of the Sworn Interpreter of the Polish Society of Sworn and Specialised Interpreters PT TEPIS and the Code of Ethics the Association of Polish Sign Language Interpreters STPJM. The aim of this article is to propose a new unified code of professional ethics for spoken language interpreters and signed language interpreters. Previous comparative research on the ethical and professional principles of interpreting, as contained in the two codes of ethics applicable to spoken or signed language interpreters, shows the universality of ethics. This follows not only from the academic need to classify and unify norms, but also from the social manifestation that, regardless of the language pair, ethics is a fundamental aspect of the profession. In the proposed code, the authors advocate a clear structure with a preamble and seven principles, which are provided with definitions and illustrated with possible ways of implementing the principles. The proposals may contribute to a discussion within the academic and professional communities about both a common code of ethics and ethics in the interpreter profession itself.
Niemieckie i polskie nazwy szkół wyższych w ujęciu języko- i przekładoznawczym (XX i XXI wiek)
Authors: Stanaszek Maciej
Published: April 2024

GERMAN AND POLISH NAMES OF HIGHER SCHOOLS FROM A LINGUISTIC AND TRANSLATIONAL PERSPECTIVE (20TH AND 21ST CENTURIES)
The present paper is an attempt to describe the nomination usus (namegiving linguistic custom) regarding higher schools of the German-speaking area on the one hand, and of the Polish-speaking one on the other. The specific semantic categories of nominal components correspond to grammatical realisations, which are subject to certain structural constraints, as well as exhibit more and less typical forms. Informed by such observations – initiated by Jan Iluk’s overview paper [2000] and refined by an analysis of much broader material, encompassing Austrian and Swiss names as well – I tried to show the name-giving possibilities and tendencies in this field in both German and Polish, mainly with a view to a translation-related application of such contrastive analysis. The findings presented here, based on the material of a considerable number of higher school names in the examined area and combined with the presentation of about 100 German and some 45 Polish examples (provided with translations), should help both in evaluating already published equivalents, hardly ever official in the case of German, and proposing one’s own ones – also because of the non-existence of given equivalents in publications, be it only Internet-based ones.
Sulfuric acid ingestion: may the severity of the metabolic acidosis be considered as a predictive sign of late damage to the gastrointestinal tract?
Authors: Mastrodicasa Elisa
Published: April 2024

Introduction: Caustic substances ingestion results in a complex syndrome. The patient characteristics and severity of injury are important prognostic predictors. The monitoring of clinical changes and the multidisciplinary approach are necessary to prevent death in the early stages of the poisoning. Case description: The case report describes the suicide of a woman by ingestion of a large amount of 15% sulfuric acid for suicidal purposes (15–20 ml). The initial conditions were stable, and no changes were found on a CT scan. However, the main sign was a severe metabolic acidosis. After 7 hours, haematemesis and oedema of the larynx appeared, and oro-tracheal intubation and ICU admission were necessary. Consequent progressive haemodynamic deterioration with persistent severe metabolic acidosis, increasing lactates and septic shock appeared. A new CT scan with contrast was performed 22 hours later detecting diffuse perforations and liquid in pleurae and abdomen. A pleural sample showed necrotic liquid. The death was 24 hours after ingestion and no surgical treatment was performed because of the diffuse lesions to the thoracoabdominal districts. Conclusions: Early detection of gastroenteric lesions and the monitoring of clinical changes are mandatory to avoid the death of the patient. Gastroenteric perforations require an immediate radiological evaluation and surgical treatment. The clinical case report states the severity of prognosis was related to high doses of sulfuric acid ingestion. The immediate metabolic acidosis is related to quick subsequent severe systemic pathological lesions of the gastrointestinal tract. The severity of absorption metabolic acidosis, consequently, may be an early and prognostic sign of the late chest and abdominal lesions.
Varicella Seroprevalence in Pediatric Populations: Results from a Single-Center Study
Authors: Kılıç Serhat , Orhan Kılıç Betül , Konuksever Dilek , Baskın Esra , Ecevit İsmail Zafer
Published: April 2024

Objective: Varicella is a highly contagious illness with potentially severe complications, especially in young children. In Turkey, the varicella vaccine was integrated into the Universal Varicella Vaccination program in 2013, targeting 12-month-old infants. While officially reported varicella cases have decreased considerably in the past two decades, underreporting remains a challenge. This study aimed to investigate varicella seropositivity in a tertiary center.
Material and Methods: A qualitative immunoassay, the enzyme-linked immunosorbent assay (ELISA), was employed to detect anti-varicella antibodies. Serum samples were collected from individuals aged 4 to 18 residing in Turkey. Information on vaccination records, varicella history, and disease notification was also collected.
Results: The varicella IgG antibody records were accessed for a total of 90 children. The overall prevalence of positive varicella antibodies was 58.0% (n=47) in the study population. Seropositivity rates were 67.2% for the 4-6 age group and 30% for the 7-12 age group. Notably, the 4-6 age group showed a significant association between seropositivity and age [p=0.005; OR=4.85; 95%CI (1.614-14.569)].
Conclusion: The seropositivity rate of 58% for chickenpox is concerning. In light of this, conducting more extensive studies will provide valuable guidance. It may be worth considering the administration of an additional dose of the varicella vaccine within the age range of 4-6 years. Further research is necessary to assess the potential benefits and feasibility of implementing such a vaccination strategy.
School nurse's screening for child maltreatment facilitates disclosure – A Swedish intervention study
Authors: Engh Lisbet , Eriksson Ulla-Britt , Jernbro Carolina
Published: April 2024

Early identification of child maltreatment (CM) is essential for children to receive support. The aim was to develop and evaluate a screening instrument for CM to be used by the school nurse in the health dialogue. The research questions included if victimisation could be disclosed by screening, if disclosure led to support measures, and the pupils' and the school nurses' experiences of the screening. A screening instrument to identify CM was developed. A total of 140 pupils and eleven school nurses participated. Mixed methods were used for analysis. Results showed that 29.7% of the participants disclosed CM victimisation and support was given when needed. Girls disclosed exposure to all types of maltreatment to a greater extent than boys. Pupils expressed the importance of screening and it created a trustful relation with the school nurse. No school nurses or pupils were distressed by the screening. Screening for CM facilitated disclosure.
Mental health crisis: The children and young people waiting years for CAMHS support
Authors: Henshaw Pete
Published: April 2024

An investigation by England's children's commissioner has revealed that more than 1 in 4 children and young people referred to CAMHS in 2022/23 were still waiting for support at the end of that year – with some 32000 having been waiting for more than two years
Declining health and wellbeing and deteriorating services
Authors: Sutton Sallyann
Published: April 2024

Data has shown that in recent years the health and wellbeing of children has been declining, this has been confirmed by SAPHNA's recent workforce survey. Meanwhile, a recent roundtable also found that the workforce is insufficient to meet demands. But not all hope is lost, Sallyann Sutton explains
Seasonality and composition of the Simuliidae fauna (Insecta: Diptera) from the altitudinal gradient in Itatiaia National Park, Brazil
Authors: LIMA-DE-SOUSA IVYN KARLA , S. MOLINA OSCAR , GIL-AZEVEDO LEONARDO H. , FIGUEIRÓ RONALDO
Published: April 2024

Black flies are abundant on all continents except Antarctica, currently being known 2,384 species, of which 97 occur in Brazil. Due to the hematophagous habit of females, they cause extreme discomfort, causing severe allergic reactions, in addition to some species being disease vectors. Abiotic factors strongly interfere with the life cycle of insects and this work seeks to understand how the distribution of Simuliidae adults is influenced at in different altitudes in the Parque Nacional de Itatiaia (PNI), Rio de Janeiro (Brazil). Three six-meter-long Malaise-type flight interception traps were installed in streams during 30 days, with two collection pots at each end. Altogether, 1,430 adult specimens of Simuliidae were analyzed, with two genera and 11 species identified. Throughout the project, four collections were made, two in the dry season and two in the rainy season. The statistical analyzes (CCA and N-MDS) showed that wind speed and altitude are the most influent factors in the distribution of species.
Predicting intensive care unit-acquired weakness: A multilayer perceptron neural network approach
Authors: Ardila Carlos Martin , González-Arroyave Daniel , Zuluaga-Gómez Mateo
Published: April 2024

In this editorial, we comment on the article by Wang and Long, published in a recent issue of the World Journal of Clinical Cases . The article addresses the challenge of predicting intensive care unit-acquired weakness (ICUAW), a neuromuscular disorder affecting critically ill patients, by employing a novel processing strategy based on repeated machine learning. The editorial presents a dataset comprising clinical, demographic, and laboratory variables from intensive care unit (ICU) patients and employs a multilayer perceptron neural network model to predict ICUAW. The authors also performed a feature importance analysis to identify the most relevant risk factors for ICUAW. This editorial contributes to the growing body of literature on predictive modeling in critical care, offering insights into the potential of machine learning approaches to improve patient outcomes and guide clinical decision-making in the ICU setting.
Transient elastography with controlled attenuation parameter for the diagnosis of colorectal polyps in patients with nonalcoholic fatty liver disease
Authors: Wang Lan , Li Yan-Fei , Dong Li-Feng
Published: April 2024

BACKGROUND

The severity of nonalcoholic fatty liver disease (NAFLD) and lipid metabolism are related to the occurrence of colorectal polyps. Liver-controlled attenuation parameters (liver-CAPs) have been established to predict the prognosis of hepatic steatosis patients.

AIM

To explore the risk factors associated with colorectal polyps in patients with NAFLD by analyzing liver-CAPs and establishing a diagnostic model.

METHODS

Patients who were diagnosed with colorectal polyps in the Department of Gastroenterology of our hospital between June 2021 and April 2022 composed the case group, and those with no important abnormalities composed the control group. The area under the receiver operating characteristic curve was used to predict the diagnostic efficiency. Differences were considered statistically significant when P < 0.05.

RESULTS

The median triglyceride (TG) and liver-CAP in the case group were significantly greater than those in the control group (mmol/L, 1.74 vs 1.05; dB/m, 282 vs 254, P < 0.05). TG and liver-CAP were found to be independent risk factors for colorectal polyps, with ORs of 2.338 (95%CI: 1.154–4.733) and 1.019 (95%CI: 1.006–1.033), respectively (P < 0.05). And there was no difference in the diagnostic efficacy between liver-CAP and TG combined with liver-CAP (TG+CAP) (P > 0.05). When the liver-CAP was greater than 291 dB/m, colorectal polyps were more likely to occur.

CONCLUSION

The levels of TG and liver-CAP in patients with colorectal polyps are significantly greater than those patients without polyps. Liver-CAP alone can be used to diagnose NAFLD with colorectal polyps.
Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning: A case report
Authors: Xu Wan-Ling , Tang Wen-Jing , Yang Wei-Ying , Sun Li-Chao , Zhang Ze-Qun , Li Wei , Zang Xiu-Xian
Published: April 2024

BACKGROUND

This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome (MODS). Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning, the intricate path to diagnosis, and the exploration of potential underlying mechanisms.

CASE SUMMARY

A patient taking 10 g of cantharidin powder orally subsequently developed MODS. The patient was treated with supportive care, fluid hydration and antibiotics, and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital admission. Cantharidin poisoning can cause life-threatening MODS and is rare clinically. This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.

CONCLUSION

This article has reported and analyzed the clinical data, diagnosis, treatment, and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.
Early embryonic failure caused by a novel mutation in the TUBB8 gene: A case report
Authors: Zhang Xiao-Yu , Zhang Xing-Xing , Wang Lei
Published: April 2024

BACKGROUND

This study aimed to explore the relationship between gene mutations and early embryonic development arrest and to provide more possibilities for the diagnosis and treatment of repeated implantation failure.

CASE SUMMARY

Here, we collected and described the clinical data of a patient with early embryonic development stagnation after repeated in vitro fertilization attempts for primary infertility at the Department Reproductive Center of Zaozhuang Maternal and Child Healthcare Hospital. We also detected the whole-exon gene of the patient's spouse and parents, and conducted bioinformatics analysis to determine the pathogenesis of the gene.

CONCLUSION

A novel mutant of the TUBB8 gene [c.602G>T(p.C201F)] was identified, and this mutant provided new data on the genotype-phenotype relationships of related diseases.
Bone block from lateral window - correcting vertical and horizontal bone deficiency in maxilla posterior site: A case report
Authors: Wang Yu-Lan , Shao Wen-Jun , Wang Min
Published: April 2024

BACKGROUND

Lateral window approach for sinus floor lift is commonly used for vertical bone augmentation in cases when the residual bone height is less than 5 mm. However, managing cases becomes more challenging when a maxillary sinus pseudocyst is present or when there is insufficient bone width. In this case, we utilized the bone window prepared during the lateral window sinus lift as a shell for horizontal bone augmentation. This allowed for simultaneous horizontal and vertical bone augmentation immediately after the removal of the maxillary sinus pseudocyst.

CASE SUMMARY

A 28-year-old female presented to our clinic with the chief complaint of missing upper left posterior teeth. Intraoral examination showed a horizontal deficiency of the alveolar ridge contour. The height of the alveolar bone was approximately 3.6 mm on cone beam computed tomography (CBCT). And a typical well-defined 'dome-shaped' lesion in maxillary sinus was observed on CBCT imaging. The lateral bony window was prepared using a piezo-ultrasonic device, then the bony window was fixed to the buccal side of the 26 alveolar ridge using a titanium screw with a length of 10 mm and a diameter of 1.5 mm. The space between the bony window and the alveolar ridge was filled with Bio-Oss, covered with a Bio-Gide collagen membrane, and subsequently sutured. Nine months later, the patient’s bone width increased from 4.8 to 10.5 mm, and the bone height increased from 3.6 to 15.6 mm. Subsequently, a Straumann® 4.1 mm × 10 mm implant was placed. The final all-ceramic crown restoration was completed four months later, and both clinical and radiographic examinations showed that the implant was successful, and the patient was satisfied with the results.

CONCLUSION

The bone block harvested from the lateral window sinus lift can be used for simultaneous horizontal bone augmentation acting as a shell for good two-dimensional bone augmentation.
Crossed renal ectopia with rectal cancer: A case report
Authors: Tang Zhen-Wei , Yang Hui-Feng , Wu Zhao-Yu , Wang Chang-You
Published: April 2024

BACKGROUND

Crossed renal ectopia (CRE) occurs when one kidney crosses the midline from the primary side to the contralateral side while the ureter remains on the primary side. Rectal cancer, one of the most common malignant tumors of the digestive tract, refers to cancer from the dentate line to the rectosigmoid junction. The concurrent presentation of CRE alongside rectal cancer is an uncommon clinical observation.

CASE SUMMARY

Herein, we report a 69-year-old male patient with rectal cancer who was diagnosed with CRE via computed tomography during hospitalization. Following thorough preoperative evaluations, the patient underwent Dixon surgery.

CONCLUSION

We performed laparoscopic radical resection of rectal cancer and adequate lymph node removal in a patient with CRE with no postoperative discomfort.
Analisis Penyakit Tuberkulosis (TBC) pada Provinsi Jawa Timur Tahun 2021 Menggunakan Geographically Weighted Regression (GWR)
Authors: Rahmawati Novi , Karno Faldianus , Hermanto Elvira Mustikawati Putri
Published: April 2024

Tuberculosis (TB) is an infectious disease with the highest mortality rate in the world. In East Java, TB cases will experience a significant increase in 2021. This study uses the Geographically Weighted Regression (GWR) method to analyze the variables that affect TB cases in East Java that year. The variables used are the number of TB cases, the number of smokers, the number poor population, and population density. The GWR results show that the number of poor people has a significant effect on all districts/cities in East Java. Meanwhile, population density has a significant effect in most areas (except Pacitan, Bondowoso, Situbondo). This research provides input for the government to reduce the number of TB cases in East Java. Efforts need to be made to increase employment and reduce regional disparities so that the burden of this disease can be controlled more effectively.

Keywords: TBC, GWR, Kernel Bisquare
Analisis Structural Equation Modeling Partial Least Square pada Kinerja Pegawai PT. Bank Pembangunan Daerah Jambi
Authors: Nurhalizah Siti , Kholijah Gusmi , Gusmanely Z
Published: April 2024

Human resource management is required to be able to continue to develop themselves in order to have high performance and be able to excel at work. The value of employee performance is important which causes the company to require employee performance to be improved. The object of research conducted at the Head Office of Bank Jambi found that there are employees who have not been able to complete the assigned tasks effectively and efficiently. The purpose of this study was to analyze the direct and indirect effects of competency variables and work discipline on employee performance variables with work motivation variables as intervening variables at Bank Jambi. Based on these problems, the results of the analysis and discussion using SEM-PLS are (1) competence and work discipline have a positive and significant effect on work motivation at Bank Jambi. Work motivation can be explained by competence and work discipline by 65.7% and 34.3% is explained by other variables outside those studied, (2) competence, work discipline, and work motivation have a direct positive and significant effect on the performance of Bank Jambi employees. Employee performance can be explained by competence, work discipline, and work motivation by 72.1% and 27.9% explained by other variables outside the study, and (3) competence and work discipline have a positive and significant indirect effect on employee performance with work motivation as an intervening variable.

Keywords: Human resources; competence; work discipline; work motivation; employee performance
Penerapan Model Log-Logistik Proporsional Hazard Untuk Menentukan Faktor yang Mempengaruhi Kondisi Financial Distress
Authors: Sudarno Sudarno , I Maruddani Di Asih
Published: April 2024

Every company is likely to experience an up or down phase in its financial performance. A decline in financial performance is a condition of financial distress. Financial distress is an event of a continuous decline in a company's financial performance over a certain period of time. The variables in this research are the response variable in the form of the time of company experiences financial distress, while the covariates are the solvency ratio, liquidity ratio, growth ratio, profitability ratio, company size and activity ratio. The aim and objective of the research is to obtain the property and significance of covariates when a company experiences financial distress. How to determine covariates that are significant to financial distress. The model used is a log-logistic proportional hazard regression model. The log-logistic model is a regression model in the form of a maximum extreme function with right asymptotics and non-negative random variables, while the Cox proportional hazards model is a survival model with the independent variables being time and covariates, between time and covariates being independent. The results of this research are that companies in the infrastructure, utilities and transportation sectors experience financial distress, influenced by solvency ratios, liquidity ratios and profitability ratios. The solvency ratio and profitability ratio have a positive effect, while the liquidity ratio has a negative effect on the timing of financial distress. The contribution of these factors to companies experiencing financial distress is 1.1% (for liquidity ratio), 3.4% (for solvency ratio), and 95.5% (for profitability ratio).

Keywords: financial distress; log-logistic; portional hazard; profitability ratio
Regresi Data Panel dalam Analisis Faktor-Faktor yang Mempengaruhi Tingkat Pengangguran Terbuka di Provinsi Daerah Istimewa Yogyakarta Tahun 2017-2021
Authors: Pamuji Agung , Setiawan Ezra Putranda , Munir Amir Mishbahul
Published: April 2024

Open unemployment is one of the most important problems in a country's economy. High unemployment rates can cause serious economic impacts, such as reduced productivity, poverty, and social instability. This problem is one that currently being faced by Indonesia, including in the Province of Special Region of Yogyakarta. This study aims to analyze the factors that influence the open unemployment rate in the Special Region of Yogyakarta Province in the 2017-2021 period. The factors tested include the Human Development Index (HDI), Regional Gross Domestic Product (Regional GDP), and District/City Minimum Wage. This study uses the panel data regression method using annual data from each district/city in the Special Region of Yogyakarta Province during the 2017-2021 period. The results showed that the Human Development Index (HDI) and District/City Minimum Wage variables positively and significantly affected the open unemployment rate in Special Region of Yogyakarta Province during the study period. Meanwhile, the GRDP variable has an insignificant effect on the open unemployment rate in the Special Region of Yogyakarta Province.

Keywords: Data Panel; TPT; IPM; UMK; PDRB
Pemodelan Data Time Series Menggunakan Pendekatan Regresi Polinomial Lokal Pada Data Harga Saham MDKA
Authors: Fauzi Febrian Adri Nur , Santoso Rukun , Maruddani Di Asih I
Published: April 2024

Investment is an important way to manage finances for profit. One of the most popular investments in Indonesia is buying and selling shares. In addition to getting profits, they also have risks.  Therefore, analyzing stock prices before buying and selling is an important key in stock investing. Investors should buy stocks at a low price and sell them at a high price. One of the methods used is parametric regression analysis, but it has assumptions that must be met. A more flexible alternative is local polynomial regression without any particular assumptions. PT Merdeka Copper Gold Tbk with MDKA stock code is a company engaged in the mining and industrialization of gold, silver, and other associated minerals. The study of modeling the lowest daily price of MDKA shares using local polynomial regression showed excellent results. The high coefficient of determination exceeding 67% on the in-sample data indicates strong model performance, and the Mean Absolute Percentage Error (MAPE) value on the out-of-sample data is less than 10%, ensuring excellent model accuracy.

Keywords: local polynomial regression; MDKA shares; time series
Becoming the Wounded Person: The Christian Vision of James Purdy’s Fiction
Authors: Adams Don
Published: April 2024

Abstract: This essay considers the fiction of James Purdy from the point of view of his self-proclaimed Christian vision, which embraces each individual as sacred through empathic understanding, eschewing objective judgment based on abstract absolutes. The essay argues that Purdy’s contrarian fiction can be understood revealingly in relation to the negative theology of Pseudo-Dionysius and Nicholas of Cusa, which envisioned a subjective, perspectival, and creatively participatory ontology that anticipated the relational and contextual paradigm of the real posited by quantum physics. Refusing reification, Purdy’s fiction vigorously negates sociopolitical idols of the self in favor of the individual’s ultimate, infinite mystery.
A Theatre of Networks: Reconceptualizing Theatre Criticism and Theatre as an Event
Authors: Akçamete Aycan
Published: April 2024

Abstract: Historically, scholarship on theater criticism has examined the boundaries of the genre and the role of the critic, while more recent works explore the changes in critical practices. This essay, however, offers a new model for understanding theater criticism, redefining reviews as “critical paratexts” (Genette) that co-construct the “theater event” in the public sphere. Taking as its case study Can Dündar’s #WeAreArrested , this paper contextualizes reviews to reveal various heavily institutionalized “critic functions” (Foucault) available for British reviewers. Ultimately, it suggests a new framework for studying theater as a cultural and political construction with more dimensions than the production/performance alone.
Erupting Presence into Absence: Possibility, Potentiality, and Performance in New Orleans’ 2019 Boycott Bowl
Authors: Franz Michael Lawrence
Published: April 2024

Abstract: This essay examines how the concept of performance developed in theatre and performance studies applies to thinking about New Orleans’ 2019 Boycott Bowl. I analyze the Boycott Bowl as a performance of protest that emerged out of what I call a moment of “negated possibility,” drawing upon ideas of possibility and potentiality outlined in Daniel Sack’s After Live: Possibility, Potentiality, and The Future of Performance. I argue that the Boycott Bowl is a productive reclamation project for the city of New Orleans that emerged from a non-productive moment on the field of play.
Bell
Authors: Orange Tommy
Published: April 2024

Abstract: Ploughshares Spring 2024 The Spring 2024 Issue. Ploughshares is an award-winning journal of new writing. Since 1971, Ploughshares has discovered and cultivated the freshest voices in contemporary American literature, and now provides readers with thoughtful and entertaining literature in a variety of formats. Find out why the New York Times named Ploughshares "the Triton among minnows." The Spring 2024 Issue, guest-edited by Laila Lalami, features poetry and prose by Mosab Abu Toha, Nathalie Handal, January Gill O'Neil, Farah Abdessamad, Francisco Goldman, Tommy Orange, and more.
La Rochelle
Authors: Mcgrath Campbell
Published: April 2024

Abstract: Ploughshares Spring 2024 The Spring 2024 Issue. Ploughshares is an award-winning journal of new writing. Since 1971, Ploughshares has discovered and cultivated the freshest voices in contemporary American literature, and now provides readers with thoughtful and entertaining literature in a variety of formats. Find out why the New York Times named Ploughshares "the Triton among minnows." The Spring 2024 Issue, guest-edited by Laila Lalami, features poetry and prose by Mosab Abu Toha, Nathalie Handal, January Gill O'Neil, Farah Abdessamad, Francisco Goldman, Tommy Orange, and more.
Angelo
Authors: Porter Andrew
Published: April 2024

Abstract: Ploughshares Spring 2024 The Spring 2024 Issue. Ploughshares is an award-winning journal of new writing. Since 1971, Ploughshares has discovered and cultivated the freshest voices in contemporary American literature, and now provides readers with thoughtful and entertaining literature in a variety of formats. Find out why the New York Times named Ploughshares "the Triton among minnows." The Spring 2024 Issue, guest-edited by Laila Lalami, features poetry and prose by Mosab Abu Toha, Nathalie Handal, January Gill O'Neil, Farah Abdessamad, Francisco Goldman, Tommy Orange, and more.
Elegy
Authors: Ronk Martha
Published: April 2024

Abstract: Ploughshares Spring 2024 The Spring 2024 Issue. Ploughshares is an award-winning journal of new writing. Since 1971, Ploughshares has discovered and cultivated the freshest voices in contemporary American literature, and now provides readers with thoughtful and entertaining literature in a variety of formats. Find out why the New York Times named Ploughshares "the Triton among minnows." The Spring 2024 Issue, guest-edited by Laila Lalami, features poetry and prose by Mosab Abu Toha, Nathalie Handal, January Gill O'Neil, Farah Abdessamad, Francisco Goldman, Tommy Orange, and more.