bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Mitigasi Risiko Pada Produksi Surimi Beku Dengan Metode House Of Risk (HOR) dan SCOR MODEL
Authors: ADELIA VONNY
Published: November 2023

PT. Starfood International adalah perusahaan yang bergerak dibidang ekspor hasil laut, yang beralamat di Jl. Raya Daendles KM 76. Desa Kandangsemangkon, Kec. Paciran Kab. Lamongan. PT. Starfood International memiliki 3 produk, salah satunya yaitu Surimi. Risiko adalah suatu kejadian atau peristiwa yang tidak diinginkan atau datang tidak diduga yang mengakibatkan kerugian. Pada identifikasi permasalahan tahap awal, kendala yang dihadapi perusahaan yaitu ketidakstabilan pasokan bahan baku berupa ikan karena bergantung pada cuaca atau faktor alam. Dengan hal itu, kendala atau tantangan yang terkait dengan perusahan perikanan dapat diminimasi dengan mengelolah proses rantai pasok / supply chain, dimana kegiatan tersebut dari memasok bahan baku hingga pendistribusian ke tangan konsumen. Penelitian ini menggunakan model  SCOR dan House Of Risk (HOR). Pada tahap HOR 1 mengidentifikasi kejadian risiko, menentukan penilaian severity, penilaian occurrence, korelasi antara risk event dengan risk agen dan perhitungan nilai ARP. Hasil dari identifikasi risiko didapatkan 13 kejadian risiko dan 20 agen risiko. Terpilih 12 agen risiko dengan nilai tertinggi kesatu,kedua dan ketiga yaitu bahan baku yang bergantung pada musim, kurangnya komunikasi antara perusahaan dengan supplier, pencucian bahan baku dilakukan secara manual. Berdasarkan nilai ARP tertinggi dan dilakukan perencanaan strategi mitigasi. Terdapat 12 strategi mitigasi yang diusulkan guna mengurangi kemungkinan risiko yang terjadi di perusahaan. Tiga diantaranya yang memiliki nilai tertinggi yaitu melakukan komunikasi dengan supplier (target/rencana,RM masuk), menjalin komunikasi dengan baik ke buyer untuk mempercepat pembayaran barang agar tidak terlambat, harus sesuai spek supplier guaranteeKata kunci: Risiko, SCOR, House Of Risk (HOR
Analysis of Soybean Supplier Selection for MSMEs Tofu Tempe Using the Analytical Hierarchy Process (AHP) Method
Authors: Hakim Luqman
Published: November 2023

In the process of processing food products which are widely produced by home industries such as tofu and tempeh, one of the things that needs to be considered is procurement management which includes raw material purchasing activities. In raw material purchasing activities, supplier selection is an important process because it can help a business in terms of reducing raw material costs, inventory costs, and distribution costs as well as encouraging efficiency in terms of production time to product marketing. Therefore, this research will explain a tough and effective supply chain management system for conducting risk assessments in supply chain management, especially in home industries using distributed analysis, impact analysis, and failure modes. Using the Analytical Hierarchy Process (AHP) method can be a solution in solving the problem of decision-making for tofu and tempeh MSMEs in Kemantren Tulangan Village, Sidoarjo in selecting the best soybean supplier using the criteria of quality, price, delivery, and service, convenience, and relationships. This research was conducted using qualitative methods. This data collection technique uses interview techniques, observation, and literature study. Meanwhile, the sampling technique used snowball sampling technique, the informants consisted of 2 people, namely the Head of Production and Administration. Based on data processing using the AHP method using the Expert Choice application, it produces weighted values for each criterion, namely quality (0.165), price (0.228), delivery (0.114), service (0.144), convenience (0.201), and relationship (0.147). Meanwhile, the weighted values for each supplier are supplier 1 (0.413), supplier 2 (0.260), and supplier 3 (0.327). From the results of this data processing, the most important criterion in selecting the best supplier is the price criterion and the priority for the best supplier is supplier 1.
Determining the fire season by analyzing climatic conditions in northeastern Serbia
Authors: Živanović Stanimir
Published: November 2023

The territory of Serbia is sensitive to forest fires, which endanger various systems and play an important role in shaping the ecosystem. The probability of the occurrence and spread of forest fires in the area of northeastern Serbia was examined, depending on the influence of climatic conditions. Changes in climatic conditions are investigated at the annual and monthly level of air temperature, precipitation and air humidity values recorded at three main meteorological stations (Zaječar, Negotin, Crni Vrh) in the area of northeastern Serbia. Changes in climatic conditions in the period 2009-2022 compared to the period 1961-1990 were analyzed, with an emphasis on 2012 and 2014. The length of the average fire season was determined through a modified version of Thornthwaite’s evapotranspiration index. The fire season is longer in the area of Negotin and Zaječar than in the area of Crni Vrh. On the basis of the monthly humidity indices, a significantly longer fire season was determined in 2012 compared to 2014, as well as the multi-year period 1961-1990.An analysis of the value of the Burning Index (B) for the period 2009-2022 was performed and a correlation was established with the data on the number of forest fires. The burning index in the area of northeastern Serbia is the highest during the months of July, August and September. Significantly higher values of the burning index are for 2012 compared to 2014, which is correlated with the occurrence of forest fires in this period.
EXAMINATION OF THE CHEMICAL COMPOSITION OF SPRING WATERS IN AKETI VILLAGE OF LANCHKHUTI MUNICIPALITY
Authors: Manuchar Chikovani  , Nino Kakhidze  , Lali Balavadze  , Nino Giorgadze  , Monika Pataridze
Published: November 2023

For the first time the hydrochemical examination of the spring waters of the village of Aketi of Lanchkhuti municipality was conducted. The content of magnesium and calcium ions, hydrocarbonate ions, chloride ions, sulfate ions, dry balance, permanganate oxidation, total iron ions, dissolved oxygen and carbon dioxide is determined. The content of total iron ions, dissolved oxygen and carbon dioxide. Relatively simple and fast chemical and physico-chemical methods with good reproducibility were selected for determination. Biogenic substances were determined by the photometric method.

Objective: We aimed to study the chemical composition of the spring waters of Aketi village of Lanchkhuti municipality. We determined the following: the content of magnesium and calcium ions, hydrocarbonate ions, chloride ions, sulfate ions, dry balance, permanganate oxidation, total iron ions, dissolved oxygen and carbon dioxide in the spring waters of Aketi village of Lanchkhuti municipalityThe relevance of the issue lies in the fact that the content of the above-mentioned ions was determined for the first time in the given waters, for which highly sensitive methods were selected.
Anet1: poprocesiranje ansambelskih vremenskih napovedi s pomočjo nevronskih mrež
Authors: Mlakar Peter , Merše Janko , Faganeli Pucer Jana
Published: November 2023

Poprocesiranje ansambelskih napovedi igra ključno vlogo pri tvorjenju natančnejših verjetnostnih napovedi vremena. Pogosto uporabljene metode za poprocesiranje verjetnostne napovedi ustvarijo ločeno za vsako lokacijo ali časovno obdobje. V tem delu predlagamo nov pristop, imenovan ANET1, ki temelji na nevronskih mrežah, ki združno tvori verjetnostne napovedi za vse lokacije in časovna obdobja. ANET1 posamično poprocesira člane ansambelske napovedi ter te uporabi za oceno parametrov normalne porazdelitve. Za učenje ter evalvacijo naše metode smo uporabili podatkovno zbirko napovedi temperatur, EUPPBench. Rezultati nakazujejo, da ANET1 izboljša delovanje obstoječih metod, predvsem v zahtevnih gorskih regijah. Prav tako zmanjša variabilnost napake napovedi tekom dnevnega hoda. V primerjavi z dvema drugim najboljšima pristopoma, EMOS in DVQR, ANET1 prinaša opazne izboljšave v umerjenosti porazdelitve napovedi glede na več evalvacijskih kriterijev.
On a boundary-value problem in a bounded domain for a time-fractional diffusion equation with the Prabhakar fractional derivative
Authors: Karimov E.T. , Hasanov A.
Published: November 2023

We aim to study a unique solvability of a boundary-value problem for a time-fractional diffusion equation involving the Prabhakar fractional derivative in a Caputo sense in a bounded domain. We use the method of separation of variables and in time-variable, we obtain the Cauchy problem for a fractional differential equation with the Prabhakar derivative. Solution of this Cauchy problem we represent via Mittag-Leffler type function of two variables. Using the new integral representation of this two-variable Mittag-Leffler type function, we obtained the required estimate, which allows us to prove uniform convergence of the infinite series form of the solution for the considered problem.
DYNAMICS OF LIPID PEROXIDATION PROCESSES AND DEVELOPMENT OF PULMONARY EDEMA FOLLOWING ACUTE BLOOD LOSS OF VARYING SEVERITY AND ITS MITIGATION
Authors: Trach N. I. , Prokhorenko O. O.
Published: November 2023

Acute blood loss stands as a primary contributor to fatalities among individuals with severe trauma. While balanced crystalloids and antioxidants are used for corrective measures, their impact on lung condition after acute blood loss remains inadequately explored. This study aims at elucidating the shifts in lipid peroxidation processes and the progression of pulmonary edema in response to varying degrees of acute blood loss and to assess the effectiveness of correction by using balanced crystalloids in combination with 2-ethyl-6-methyl-3-hydroxypyridine succinate. Materials and methods. Acute blood loss of 1 and 2% of body weight was modeled in the experiments on rats and to assess the efficacy of its correction by using lactated Ringer’s solution separately and in combination with 2-ethyl-6-methyl-3-hydroxypyridine succinate. We determined the levels of reagents reacting with thiobarbituric acid in lung parenchyma and bronchoalveolar lavage, as well as the index of pulmonary edema at intervals of 1, 3, and 7 days during the post-traumatic period. Results. Our findings revealed that the simulation of acute blood loss at 2% of body weight resulted in significantly greater increases in lipid peroxidation processes in both lung parenchyma and bronchoalveolar lavage when compared to rats simulating blood loss at 1% of their body weight. Starting from the 3rd day of the experiment, this also led to a higher index of pulmonary edema. The administration of lactated Ringer's solution in a 1:1 ratio relative to the volume of lost blood, in combination with 2-ethyl-6-methyl-3-hydroxypyridine succinate, produced statistically significant improvements in the examined parameters compared to rats receiving an equivalent dose of lactated Ringer's solution alone. Conclusions. Acute blood loss equivalent to 2% of body weight leads to a more pronounced activation of lipid peroxidation processes in lung tissues and bronchoalveolar lavage, accompanied by an increase in the pulmonary edema index when compared to blood loss equivalent to 1% of body weight. The combined administration of lactated Ringer's solution and 2-ethyl-6-methyl-3-hydroxypyridine succinate yields a more substantial corrective effect compared to rats treated solely with lactated Ringer's solution.
EPIGALLOCATECHIN-3-GALLATE ALLEVIATES METABOLIC DISORDERS IN RATS SIMULTANEOUSLY EXPOSED TO ROUND-THE-CLOCK LIGHTING AND KEPT ON HIGH-CALORIE CARBOHYDRATE-LIPID DIET
Authors: Frankel Yu.D. , Cherno V.S.
Published: November 2023

The aim of the study is to investigate the effect of epigallocatechin-3-gallate (EGCG) on the parameters of carbohydrate and lipid metabolism in the blood serum of rats exposed to round-the-clock lighting (RCL) and kept on high-calorie carbohydrate-lipid diet (HCCLD). The experiments were performed on 21 white Wistar rats weighing 210-250 g, divided into 3 groups. Animals in the first group (control) received a standard diet (energy value 2720 kcal/kg) and were exposed to an equally altered light and darkness periods. The rats of the second and third groups were under the constant round-the-clock light exposure and received HCCLD (4477 kcal/kg). In addition to the conditions in the second group, the test animals of the third group were administered EGCG daily through intragastric gavage in a dose of 40 mg/kg. An enzyme-linked immunosorbent assay kit for rat serum was used to assess insulin concentration. The concentration of serum glucose, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and triacylglycerols (TAG) was determined by enzymatic methods using photometric equipment. Insulin resistance was assessed by the HOMA-IR (Homeostatic Model Assessment) index. With the administration of EGCG, the concentration of glucose and insulin in the blood serum decreased by 34.7% and 59.1%, respectively, compared to group 2, and the HOMA-IR was 61.5% lower than in the comparison group. The HDL content increased with the administration of EGCG in the experiment and was 91.3% higher compared to the findings in the group 2. Under these circumstances, the concentrations of VLDL and TAG in the blood serum were significantly lower by 37.5 and 37.1% than the respective values in the group 2. It can be suggested that the administration of the bioflavonoid epigallocatechin-3-gallate significantly alleviates metabolic disorders in rats simultaneously exposed to RCL and kept on HCCLD.
RETENTION OF MANDIBULAR MOLARS: ETIOLOGICAL FACTORS, CURRENT DIAGNOSTIC APPROACHES, AND TREATMENT OPTIONS
Authors: Shaienko D.P
Published: November 2023

The problem of tooth eruption is a common issue affecting nearly 20% of the population. Along with this, there is a growing trend of increased dentoalveolar anomalies in children and adults. One of such anomalies is the retention of the mandibular molars, which has always been a complex dentoalveolar pathology posing clinical challenges for orthodontists and oral surgeons. The aim of this study is to review and analyze relevant literature sources regarding the current etiological factors, diagnostic methods and treatment options for the retention of the mandibular molars. Tooth eruption is a complex and highly regulated process, which is currently the subject of research by many authors. There are various theories about the process of tooth eruption, often contradicting each other. Retention of molars should be considered as a pathological phenomenon with a multifactorial aetiology. Consequently, the approach to the diagnosis and treatment of this pathology cannot be standardized or unified. Therefore, there is a tendency to personalized approach both in the diagnosis and treatment of patients with dentoalveolar anomalies. In most cases, the diagnosis of molar retention is based on a clinical and x-ray examination. Notably, decision-making and treatment strategy selection rely on constantly evolving methods. Unfortunately, the acceleration and early completion of bone tissue maturation increase the frequency of tooth retention, pushing clinicians towards the early intervention. This, in turn, requires a revision of existing recommendations and protocols. The development of technology and the modern possibilities of digital planning open up new horizons and provide tools for addressing complex challenges; however, they require a multidisciplinary approach to implementing non-standard treatment methods involving both orthodontists and oral surgeons. Apparently, all novel techniques require careful analysis, which provides researchers with space for further investigations.
ROLE OF ZINC IN HUMAN BODY AND APPROACHES TO OVERCOME ITS DEFICIENCY
Authors: Akimov O.Ye. , Kuznetsova T.Yu. , Solovyova N.V. , Mishchenko A.V. , Zakolodna O.E. , Soloviev V.V.
Published: November 2023

The important role of zinc in living organisms is mediated by its participation in many physiological processes. It is present in all tissues, organs, and secretions of the human body and is one of the most essential and important trace elements for the human body. This trace element is essential for catalytic activity and is a structural component of about 200 metalloenzymes involved in various metabolic pathways (DNA and RNA polymerases, dehydrogenases, carboxypeptidases, phosphatases, superoxide dismutases, alcohol dehydrogenases, pyruvate carboxylases, and many others). The biological role of zinc in the human body is largely realised in the processes of energy metabolism, in the synthesis and stabilisation of nucleic acids and proteins, in maintaining the antioxidant status, cell proliferation and differentiation. According to WHO estimates, about 31% (from 4 to 73%) of the world's population suffer from zinc deficiency. Zinc deficiency in the human body can occur for many reasons, including malnutrition, impaired absorption in the intestinal mucosa, inadequate or impaired binding of zinc to albumin, poor absorption of zinc by cells, competition with other metals, a high-fibre diet that impairs zinc absorption, disorders of transferrin synthesis, pancreatic function, diarrhoea, etc. A decrease in the zinc content in the body is accompanied by impaired chemotaxis of polymorphonuclear lymphocytes, natural killer cells, slowing down phagocytosis, and the activity of calprotectin production mechanisms. In order to correct metabolic disorders in various diseases caused by zinc deficiency in the human body, it is proposed to use a mixture for the preparation of an oxygen cocktail enriched with zinc ions, which allows for specific prevention and correction of zinc deficiency states and has an immunomodulatory effect.
INFRARED SPECTROSCOPY AND ITS APPLICATION IN MEDICAL AND BIOLOGICAL RESEARCH
Authors: Sheiko V. , Kuchmenko O. , Havii V. , Pasichnyk S.
Published: November 2023

Infrared spectroscopy is a spectral research method based on the ability of molecules to absorb infrared radiation with a certain wavelength. Due to the fact that the absorption spectra for different substances are specific and unique, this method is used for the identification of substances, the study of materials, and the study of biomolecules, in particular in the medical field. Infrared spectroscopy serves a multifaceted role in various scientific applications: it is employed to assess the purity and composition of drugs; it enables studying the biochemical makeup of cells of various types, labeling transformed cells, facilitating photodynamic therapy, and exploring the dynamics of in vivo drug release. This method occupies a special place during surgical interventions to identify transformed cells and differentiate them from healthy ones. Thus, during a tumor resection operation, there are risks of excessive or insufficient removal of transformed tissues, which can cause complications, a prolonged period of postoperative intervention, or the absence of remission, in the case of an insufficiently removed tumor. In this case, infrared spectroscopy enables quick and accurate differentiating between healthy and pathological cells, this procedure is fast, accurate, and does not require lengthy sample preparation. Based on the indicators and the ratio of peak intensities, the use of FTIR spectroscopy enables to determine both the qualitative and quantitative composition of proteins and lipids in the transformed cells that can differ and depends on the distance to the tumor. Therefore, in order to introduce and standardize this procedure into surgical interventions and post-operative studies, it is essential to establish comprehensive catalogs of lipidomes and proteomes for various cell types, acquired through the application of infrared spectroscopy.
IMPACT OF PARAVERTEBRAL BLOCKADE ON THE COURSE OF EARLY POSTOPERATIVE PERIOD FOLLOWING SURGICAL INTERVENTION FOR LUNG MALIGNANCIES UNDER INHALED SEVOFLURANE ANESTHESIA
Authors: Suprun A. S.
Published: November 2023

The aim of the study is to investigate the impact of paravertebral blockade on the quality of anti-stress protection of general inhalation anaesthesia based on sevoflurane during operations in patients with lung malignancy. Material and methods. We examined 60 individuals of an average age 55±5.6 years, whose physical status was assessed as class II – III according to the ASA classification. The patients underwent open surgical procedures, including frontal or pneumonectomy, or partial lung resection. The patients were divided into 2 groups depending on the method of anaesthesia: SF group (sevoflurane) (n = 29) received inhaled anaesthesia with sevoflurane; SF+PVB group (n = 31) received the combination of inhaled anaesthesia with PVB. The following indicators were assessed: time of the first administration of the analgesic after surgery, pain intensity by the visual analogue scale (VAS), perfusion systemic pressure (PST), cardiac index (CI), oxygen content in arterial and venous blood, blood lactate levels, indicators of circulatory energy efficiency, cortisol, insulin and HOMA index levels. Indicators were recorded before the surgical operation, at the wake-up stage, on the 1st and 5th days following the operation. Results. In the SF+PVB group, the intensity of pain in the postoperative period was significantly lower than in the SF group. In the SF+PVB group, there was no necessity for administering narcotic analgesics on the first day, while in the SF group, the dose of morphine was 0.27±0.04 mg/kg∙day, the first administration was performed 65.5±10.3 minutes after surgery. CI during surgery and in a day was significantly higher in the SF+PVB group, and the arteriovenous difference in oxygen content was significantly lower. The energy efficiency of blood circulation at the same stages was significantly higher in the SF+PVB group. In the same group, there was a significantly lower concentration of markers of stress responses (cortisol levels and HOMA index). Conclusions. The use of paravertebral blockade under the general anaesthesia based on sevoflurane during operations in patients with lung malignancies contributes to a significant reduction in the pain intensity in the postoperative period; eliminates the need to use narcotic analgesics; provides significantly more stable hemodynamics and significantly more adequate oxygen supply during the operation and in the postoperative period; significantly reduces the intensity of stress reactions as well as significantly improves the energy efficiency of blood circulation.
Another application of Smarandache based ruled surfaces with the Darboux vector according to Frenet frame in $E^{3}$
Authors: ŞENYURT Süleyman , CANLI Davut , ÇAN Elif , GÜR MAZLUM Sümeyye
Published: November 2023

In this study, we first define the Smarandache curves derived from the Frenet vectors and the Darboux vector of any curve. Then, we construct new ruled surfaces along these Smarandache curves with the direction vectors obtained from the Frenet vectors and the Darboux vector, and give the equations of these surfaces. In addition, we calculate the Gaussian and mean curvatures of these surfaces separately and present the conditions to be minimal and developable for these surfaces. Finally, as an example, we obtain ruled surfaces whose base curves are Viviani’s curves and plot the graphics of these surfaces.
The type I heavy-tailed odd power generalized Weibull-G family of distributions with applications
Authors: MOAKOFİ Thatayaone , OLUYEDE Broderick
Published: November 2023

In this study, we propose a new heavy-tailed distribution, namely, the type I heavy-tailed odd power generalized Weibull-G family of distributions. Several statistical properties including hazard rate function, quantile function, moments, distribution of the order statistics and Renyi entropy are presented. Actuarial measures such as value at risk, tail value at risk, tail variance and tail variance premium are also derived. To obtain the estimates of the parameters of the new family of distributions, we adopt the maximum likelihood estimation method and assess the consistency property via a Monte Carlo simulation. Finally, we illustrate the usefulness of the new family of distributions by analyzing four real life data sets from different fields such as insurance, engineering, bio-medical and environmental sciences.
BMO estimate for the higher order commutators of Marcinkiewicz integral operator on grand Herz-Morrey spaces
Authors: SULTAN Babar , SULTAN Mehvish , GÜRBÜZ Ferit
Published: November 2023

Let $\mathbb{S}^{n-1}$ denote the unit sphere in $\mathbb{R}^n$ with the normalized Lebesgue measure. Let $\Phi\in L^{r}(\mathbb{S}^{n-1})$ is a homogeneous function of degree zero and $b$ is
a locally integrable function on $\mathbb{R}^n$. In this paper we define the higher order commutators of Marcinkiewicz integral $[b,\mu_{\Phi}]^m$ and prove the boundedness of $[b,\mu_{\Phi}]^m$ under some proper assumptions on grand variable Herz-Morrey spaces $M\dot{K}^{\alpha(.),\beta}_{u,v(.)}(\mathbb{R}^n)$.
Sicherheit und Zuverlässigkeit im Bauwesen
Authors: Schneider Jörg
Published: November 2023

Sicherheit ist eines der wesentlichen Stichworte unserer Zeit, nicht zuletzt auch im Bauwesen. Das Buch durchleuchtet diesen Aspekt in großer thematischer Breite. Als entscheidende Voraussetzung für die Schaffung von Sicherheit im Bauwesen werden im ersten Teil Methoden der Gefährungsanalyse und Elemente der Massnahmenplanung behandelt. Weiter findet sich eine Einführung in das elementare Grundwissen der Statistik und Wahrscheinlichkeitslehre sowie in die Aufarbeitung von Daten in eine von der Zuverlässigkeitstheorie geforderten Form. Den zentralen Teil des Buches bildet die Zuverlässigkeitstheorie in der auf kleine Versagenswahrscheinlichkeiten ausgerichteten Form. Die wichtigsten Rechenverfahren werden unter weitgehendem Verzicht auf Herleitung dargestellt. Beispiele, meist aus dem statisch-konstruktiven Bereich des Bauingenieurwesens, machen das Erläuterte verständlich - auch für einen mit der Thematik wenig vertrauten Leser. Die Gefährdungsanalyse mit logischen Bäumen, d.h. mit Ereignis-, Fehler- und Entscheidungsbäumen ist in den wesentlichen Ansätzen ebenfalls behandelt. Die Sicherheit im Bauwesen wird entscheidend durch Fehlhandlungen der beteiligten Menschen beeinträchtigt. Praxisnah und konkret schildert der Autor, wie die im Bauwesen tätigen Fachleute in den verschiedenen Arbeitsphasen Fehler verhüten bzw. durchgeschlüpfte Fehler noch rechtzeitig entdecken können. Am Schluß wird gezeigt, auf welche Kriterien sich der Entscheid stützt, gewisse Risiken im konkreten Fall zu akzeptieren, denn ohne Risiko kann man bekanntlich nicht bauen. Ein umfangreicher Anhang bietet Hilfsmittel für die praktische Arbeit sowie ausführliche Begriffs- und Literaturverzeichnisse.
A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images
Authors: Ibrahim Yehia , Xie Jianyang , Macerollo Antonella , Sardone Rodolfo , Shen Yaochun , Romano Vito , Zheng Yalin
Published: November 2023

Background:

Traditional methods for diagnosing dementia are costly, time-consuming, and somewhat invasive. Since the retina shares significant anatomical similarities with the brain, retinal abnormalities detected via optical coherence tomography (OCT) and OCT angiography (OCTA) have been studied as a potential non-invasive diagnostic tool for neurodegenerative disorders; however, the most effective retinal changes remain a mystery to be unraveled in this review.

Objective:

This study aims to explore the relationship between retinal abnormalities in OCT/OCTA images and cognitive decline as well as evaluating biomarkers’ effectiveness in detecting neurodegenerative diseases.

Methods:

A systematic search was conducted on PubMed, Web of Science, and Scopus until December 2022, resulted in 64 papers using agreed search keywords, and inclusion/exclusion criteria.

Results:

The superior peripapillary retinal nerve fiber layer (pRNFL) is a trustworthy biomarker to identify most Alzheimer’s disease (AD) cases; however, it is inefficient when dealing with mild AD and mild cognitive impairment (MCI). The global pRNFL (pRNFL-G) is another reliable biomarker to discriminate frontotemporal dementia from mild AD and healthy controls (HCs), moderate AD and MCI from HCs, as well as identifing pathological Aβ42/tau in cognitively healthy individuals. Conversely, pRNFL-G fails to realize mild AD and the progression of AD. The average pRNFL thickness variation is considered a viable biomarker to monitor the progression of AD. Finally, the superior and average pRNFL thicknesses are considered consistent for advanced AD but not for early/mild AD.

Conclusions:

Retinal changes may indicate dementia, but further research is needed to confirm the most effective biomarkers for early and mild AD.
Linking Cognitive Impairment with Amyloid-β Accumulation in Alzheimer’s Disease: Insights from Behavioral Tests and FTIR Spectroscopy
Authors: Gaber Heba Ahmed , Aly Eman Mohamed , Mohamed Eman Saad , Elfoly Marwa , Rabie Mostafa Adel , Talaat Mona Salah , El-Sayed El-Sayed Mahmoud
Published: November 2023

Background:

Alzheimer’s disease (AD) is a neurodegenerative disorder that progresses over time. Fourier Transform Infrared Spectroscopy (FTIR) analysis gives identification of the main metabolic changes that happen during neurodegeneration, by monitoring biochemical and molecular structure alterations that can help in AD diagnosis or treatment approach.

Objective:

The aim of the present work is to assess AD hallmarks in molecular structure of retina and monitor accumulation of amyloid beta42(Aβ42) in brain and retina during disease progression.

Methods:

AD induced in rats by Aluminum Chloride (AlCl3). Retinal molecular structure during disease progression for 2,4,6 and 8 weeks was assessed by Fourier-transform infrared spectroscopy (FTIR) and the incidence of the disease was confirmed by a behavioural assessment; the Morris Water Maze test. Aβ42 levels in the brain and retina were also measured.

Results:

The results indicated that cognitive impairment starting from 6 weeks of AlCl3 administration. Retinal concentration of Aβ42 was significant increase ( p < 0.05) from 2 weeks that precedes the observed increase of Aβ42 in the brain which appeared after 4 weeks of AlCl3 administration. Multivariate principal component analysis discovers that the variance noticed in the infrared spectra due to AD condition and it is time dependent for progression of the disease.

Conclusions:

The accumulation of Aβ42 is a sensitive early biomarker in retina for AD. FTIR analysis of the retina revealed changes in hydrogen bond formation or destruction, alterations in lipid chain length and branching accompanied by depleted lipid content and carbonization, as well as degeneration of the retinal tissue due to AD.
Norms for the Triana Test: A Story Recall Test Based on Emotional Material
Authors: Luque-Tirado Andrea , Montiel-Herrera Fátima , Maestre-Bravo Rebeca , Barril-Aller Claudia , García-Roldán Ernesto , Arriola-Infante José Enrique , Sánchez-Arjona María Bernal , Rodrigo-Herrero Silvia , Vargas-Romero Juan Pedro , Franco-Macías Emilio
Published: November 2023

Background:

The “Triana Test” is a novel story recall test based on emotional material with demonstrated accuracy in diagnosing mild cognitive impairment patients.

Objective:

This study aims to obtain normative data for the “Triana Test”.

Methods:

A normative study was conducted at a university hospital in Spain. Partners of patients were systematically recruited if eligible (age ≥50, no memory complaints, and a total TMA-93 score at or above the 10th percentile). The “Triana Test” was administered and scored. For developing the normative data, a regression-based method was followed.

Results:

The final sample included 362 participants (median age = 66, range = 50–88; 64.9% females). A model including age and educational level better predicted the total scores. Combinations of these variables resulted in different 10th percentile scores.

Conclusions:

Norms for using the “Triana Test” are now available. The provided cutoffs for the 10th percentile will aid in the diagnosis of prodromal Alzheimer’s disease.
Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice
Authors: Koulousakis Philippos , Willems Emily , Schepers Melissa , Rombaut Ben , Prickaerts Jos , Vanmierlo Tim , van den Hove Daniel
Published: November 2023

Background:

Current treatment options for Alzheimer’s disease (AD) are limited, inefficient, and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of central processes, such as social and reproductive behaviors. Among others, it has garnered attention in various domains of psychiatric research, while its role in the development and course of neurodegenerative disorders like AD is rather unknown.

Objective:

This study aimed to investigate the role of exogenous oxytocin administration on memory, specifically in view of AD, as a potential novel treatment option.

Methods:

We describe a novel treatment approach by using a relatively low dose of long-term intranasal oxytocin treatment, to restore memory deficits in female APPswePS1dE9 mice.

Results:

Female APPswePS1dE9 mice treated with oxytocin showed increased spatial memory performance in the object location task and improved working memory in the Y-Maze, while indicating decreased sociability.

Conclusions:

These results indicate that oxytocin is able to reverse acquired cognitive deficits in female APPswePS1dE9 mice.
Andre Wainen's Rhapsody for Alto Saxophone and Orchestra or Piano in the Representation of the "New Academicism" of Post-Avant-Garde Art
Authors: Li Yuxuan
Published: November 2023

The purpose of the research is to understand the stylistic quality of A. Waingnein's Rhapsody in the direction of the musical-instrumental specificity of the post-post-avant-garde stage of music, which we call "new academicism" within the post-avant-garde stratum of creativity. As a methodological basis, we put forward the intonation approach of the B. Asafiev school in Ukraine, as it developed in the works of D. Androsova, O. Markova, O. Muravska, with an emphasis on hermeneutic and stylistic-comparative analysis, as well as relying on the developments of the post-post-avant-garde in works Drozdovskyi, I. Navoieva, and others. Scientific novelty is determined, firstly, by the primacy in Ukrainian and Chinese musicology of the analysis of the named work by A. Waingnein, and secondly, by the originality of theoretical conclusions regarding the "new academicism" within the framework of post-avant-garde stylistics. Conclusions. The post-post-avant-garde stage of the development of art from the 2000s to the 2010s emphasises, despite the playful stylistic eclecticism of post-avant-garde creativity, the revival of the pathos beginning indicative of classical art, which tends to put forward the popular layer as a pathos-accentuation of expression in the work. Waingnein's academic approach unfolds the traditionalist stylistic dimensions inherited from the last century, emphasising as culminating "surges" (the absence of dramatic antitheticity in the composition "relieves" the tension of the dramaturgically essential) genre fragments of the work's thematics, which have been tested by the popular musical layer.

Keywords: musical genre, style in music, rhapsody, post-avant-garde, "new academicism", musical instrumentalism.
Interaction of Cultural Components in the Musical Art of China in the Context of Globalisation Influences
Authors: Liu Junyi
Published: November 2023

The purpose of the article is to analyse the interaction of Chinese and global elements in music and to highlight how Chinese actively construct their identity through musical discourse. The research employs methods of literary source analysis, conceptual analysis, and methods of cultural analysis to reveal the role of music in the construction of cultural identity. Special attention is given to the analysis of cultural transformations, dynamics of interaction between Chinese and global cultural elements in the field of musical art. The scientific novelty lies in studying the interaction of different cultural components in the musical context of China in the conditions of globalisation. Conclusions. The research results allow us to define the role of music in the formation and preservation of cultural identity in the conditions of variability and cultural interaction. Understanding the essence of music and studying the achievements of their predecessors, the Chinese community employs historically and culturally rooted ideologies and practices to guide their musical discourse. It is argued that Chinese music can acoustically express their national identity, even if the sounds include elements that have external origins or are associated with other cultures. Music emerges as a platform where different nationalities can effectively communicate both among themselves and with representatives of other cultures, expressing their personal and authentic identity.

Keywords: Chinese music, cultural identity, globalisation, musical dialogue, cultural components.
KONSEP DAN DATA MODEL APLIKASI LELANG KOMODITAS PERTANIAN BERBASIS ANDROID
Authors: Abid Awaludin
Published: November 2023

Concept and data model of application can be implemented in the Auction sector, especially for agricultural commodities. The main benefit for farmers is to increase income because it expands market segmentation,for governments to monitor the pace and development of agriculture in an area. The application is designed in android system,that has high mobility so it is easy to use anywhere as long as it has an internet network, the addition of a price check facility from auction results in the application is expected to add information to farmers and buyers in order to reduce disinformation about the price of an agricultural commodity.
PENGARUH KINERJA KEUANGAN TERHADAP RETURN SAHAM PADA SEKTOR PROPERTI DAN REAL ESTATE PERIODE TAHUN 2019-2021 DENGAN INFLASI SEBAGAI VARIABEL MODERASI
Authors: Hartati Yuli Rien , Zakiyah Tuti
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Return on Asset (ROA), Earning Per Share (EPS), Current Ratio (CR) dan Debt to Equity Ratio (DER) terhadap return saham dengan inflasi sebagai variabel moderasi pada perusahaan property dan real estate periode 2019-2021. Populasi yang digunakan dalam penelitian ini adalah perusahaan property dan real estate yang terdaftar di Bursa Efek Indonesia (BEI) dengan jumlah keseluruhan 83 perusahaan. Metode pengambilan sampel pada penelitian ini adalah metode purposive sampling dengan jumlah sampel sebanyak 41 perusahaan sehingga menghasilkan data berjumlah 123. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi data panel dan Moderated Regression Analysis (MRA) dengan menggunakan progam Eviews 12 versi student lite. Hasil penelitian ini menunjukkan bahwa Return on Asset (ROA), Earning Per Share (EPS) dan Debt to Equity Ratio (DER) tidak berpengaruh terhadap return saham, Current Ratio (CR) berpengaruh positif terhadap return saham serta inflasi mampu memperlemah pengaruh Return on Assets (ROA) terhadap return saham, inflasi tidak mampu memoderasi pengaruh Earning Per Share (EPS), Current Ratio (CR) dan Debt to Equity Ratio (DER) terhadap return saham.
SELEKSI CALON PENERIMA BANTUAN SOSIAL MENGGUNAKAN METODE SIMPLE ADDITIVE WEIGHTING (SAW)
Authors: Rohmatulloh Muhamad Ikhsanuddin
Published: November 2023

Bantuan sosial merupakan upaya pemerintah bertujuan untuk mewujudkan keadilan social bagi seluruh rakyat Indonesia berdasarkan amanat Undang-Undang Dasar  1945. Upaya pemerintah dalam memberikan bantuan tentunya memiliki keterbatasan anggaran sehingga kuota jumlah penerimanya dibatasi. Keterbatasan inilah mendasari perlunya seleksi calon penerima bantuan dengan cara memberikan survey dengan pertanyaan sebagai kriteria dalam seleksi tersebut sesuai dengan tingkat prioritas. Penentuan calon penerima bantuan biasanya membuat pemangku kepentingan memiliki keterbatasan dalam menentukan quota terebut sehingga diperlukan system pendukung keputusan untuk membantu menentukan rekomendasi calon penerima bantuan social dengan perangkingan kandidat sesuai prioritas kriteria. Metode simple additive weight membantu dalam memecahkan masalah sesuai dengan tingkat prioritas kriteria yang telah ditentukan sehingga menghasilkan rangking rekomendasi calon penerima bantuan.
ЮВЕНАЛЬНА ПРОКУРАТУРА: ІСТОРИЧНІ ТА ПРАКТИЧНІ АСПЕКТИ ДІЯЛЬНОСТІ
Authors: ТАТАРІНОВ Вадим , ТАТАРІНОВА Анна , КРИВЕЦЬ Олег , СЯБРЕНКО Вікторія , ТАТАРІНОВА Анастасія
Published: November 2023

У статті розглянуто процес становлення та розвитку ювенальної юстиції від зародження до повноцінної державної політики, розглянуто і висвітлено особливості роботи ювенального прокурора у кримінальному провадженні щодо неповнолітнього, звернено увагу на важливість ефективного функціонування ювенальної юстиції в Україні. Зокрема, було досліджено, що перші прояви особливого підходу до неповнолітніх у судочинстві прослідковуються у римському праві, а саме в законах XII таблиць. Проте тільки наприкінці XIX століття можна помітити перелом у сфері ювенальної юстиції, коли 2 липня 1899 р. у Чикаго (штат Іллінойс) було створено спеціальний суд у справах неповнолітніх. Від цього історичного періоду і до наших днів становлення та розвиток ювенальної юстиції стає на порядок денний у більшості країн світу. Авторами було досліджено низку міжнародних договорів у сфері захисту прав та свобод неповнолітніх, зокрема: Конвенція ООН про права дитини 1989 р., Мінімальні стандартні правила Організації Об’єднаних Націй, що стосуються відправлення правосуддя щодо неповнолітніх («Пекінські правила») від 29 листопада 1985 року, Керівні принципи ООН для попередження злочинів серед неповнолітніх, 1990 р. («Ер-Ріядські керівні принципи») та ін. Також було досліджено ряд нормативно-правових актів українського законодавства щодо особливостей роботи ювенального прокурора. У статті звернено увагу на те, що основним завданням ювенального прокурора у кримінальному провадженні щодо неповнолітнього є захист прав та інтересів та забезпечення, у визначених законом випадках, «відстороненості» від кримінального процесу. Авторами наголошено, що ефективно функціонуюча ювенальна юстиція забезпечує зменшення травмуючого досвіду для неповнолітніх, що в подальшому призводить до зменшення вчинення ними кримінальних правопорушень.
ОЦІНКА ПОРУШЕННЯ ФУНКЦІОНУВАННЯ ПАЦІЄНТІВ ІЗ БОЛЕМ У НИЖНІЙ ДІЛЯНЦІ СПИНИ
Authors: Овдій М. О.
Published: November 2023

Біль у нижній ділянці спини (БНДС) є п’ятою за поширеністю причиною звернення за медичною допомогою та вражає майже 60–80 % людей протягом життя. Ця проблема об’єднує спеціалістів різних клінічних напрямків і потребує мультидисциплінарного підходу до лікування. Розуміння патогенетичних механізмів виникнення БНДС і тих функціональних обмежень, які виникають, дозволяє оптимізувати підходи до лікування та вибрати необхідні реабілітаційні інтервенції. Мета – оцінити порушення функціонування пацієнтів із БНДС залежно від локалізації болю та неврологічного статусу пацієнта. Матеріал. Проведено реабілітаційне обстеження та анкетування 138 осіб із БНДС, що були направлені до амбулаторного реабілітаційного відділення. Для розподілу пацієнтів залежно від топографії болю та наявності чи відсутності неврологічного дефіциту було застосовано Класифікацію захворювань хребта Квебекської спеціальної комісії. Для оцінки порушення функціонування було проведено анкетування за Quebec Back Pain Disability Scale. Результати. Розподіл пацієнтів за категоріями Класифікації захворювань хребта Квебекської спеціальної комісії показав, що 48 % осіб мали БНДС без іррадіації та неврологічного дефіциту, 18 % мали БНДС з іррадіацією до коліна, неврологічний дефіцит відсутній, 14 % мали БНДС з іррадіацією нижче коліна, неврологічний дефіцит відсутній, у 15 % досліджуваних спостерігався БНДС з іррадіацією в ногу, неврологічний дефіцит присутній та у 5 % спостерігався стан після операції на хребті ≤ 6 місяців з моменту операції. За результатами анкетування за Quebec Back Pain Disability Scale було встановлено, що пацієнти з БНДС з іррадіацією в ногу та неврологічним дефіцитом мали найвищий рівень порушення функціонування – 29,2±12,7 бала в порівнянні з іншими пацієнтами. Висновки. Рівень порушення функціонування пацієнтів з БНДС залежить від інтенсивності болю, локалізації болю та ступеня вираженості неврологічних симптомів. Пацієнти з болем у нижній ділянці спини з іррадіацією в ногу та неврологічним дефіцитом мають вищий рівень порушення функціонування в порівнянні з іншими пацієнтами.
СУЧАСНИЙ ПОГЛЯД НА ПРОБЛЕМУ ВИКОРИСТАННЯ СПОСОБУ ЖИТТЯ ЯК ЗАСОБУ НЕМЕДИКАМЕНТОЗНОЇ ТЕРАПІЇ МЕТАБОЛІЧНОГО СИНДРОМУ
Authors: Калмикова Ю. С.
Published: November 2023

Мета статті полягає в аналізі літератури, присвяченої вивченню сучасних поглядів на здоровий спосіб життя для осіб із метаболічним синдромом. Методи дослідження. Використано аналітичний та бібліосемантичний методи. Проведено огляд та аналіз сучасної вітчизняної та зарубіжної літератури, присвяченої немедикаментозній терапії метаболічного синдрому. Результати. Метаболічний синдром залишається найважливішою проблемою суспільства у зв’язку з ранньою та високою інвалідизацією, передчасною старістю й смертністю. Важливим є те, що метаболічний синдром є станом, зворотним при відповідному своєчасному лікуванні. Зміна способу життя є одним із найголовніших підходів до лікування метаболічного синдрому, який включає в себе корекцію надлишкової маси, підвищення фізичної активності та ін. В усуненні наслідків метаболічного синдрому значну роль відіграє підвищення фізичної активності. Застосування фізичних навантажень підвищує окислювальні процеси в м’язах, а тому посилюється витрата вуглеводів і жирних кислот. Фізична активність сприяє використанню інтрам’язових тригліцеридів та вільних жирних кислот в якості енергетичного матеріалу, зниженню інсулінорезистентності. Фізична активність – найбільш істотний захід для контролю маси тіла. Навіть при відсутності втрати маси тіла фізична активність асоціюється з багатьма сприятливими ефектами, такими, як поліпшення функціонального стану серцево-судинної системи та можливе зниження інсулінорезистентності. Фахівці вважають, що саме тренування динамічного характеру викликають більш значуще збільшення функціональних можливостей системи кровообігу, а оптимальним варіантом використання фізичних вправ є комбінація статико-динамічних навантажень. Підвищують чутливість тканин до інсуліну аеробні навантаження, та необхідно враховувати, що динамічні навантаження є досить важкими для осіб з ожирінням. Фізичні вправи виконуються в середньому темпі, з максимальною амплітудою, однак, з урахуванням фізичних можливостей пацієнта. До того ж клінічні дослідження Diabetes Prevention Program свідчать про те, що фізична активність пацієнтів з інсулінорезистентністю, дієти та зміна способу життя знижують кількість нових випадків розвитку ЦД2 більш ефективно, ніж застосування медикаментозної терапії. Висновки. Поширення метаболічного синдрому набуло епідемічного характеру в Україні. Однією з важливих складових патогенезу метаболічного синдрому є абдомінальне ожиріння. Фахівці приділяють значну увагу зниженню маси тіла за рахунок способу життя, а саме фізичної активності, харчової поведінки, відмови від шкідливих звичок.