bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacometrics: Application in Drug Development and Clinical Practice
Authors: Mankar S. D. , Pawar Tanishka , Musale Prerana
Published: October 2023

In the last 4 years, pharmacometrics (PMX) has advanced to the point that it is now a crucial part of drug development. Drug delivery systems and molecules with more complex architecture are being developed as technology advances. Pharmacodynamic modelling is based on the quantitative integration of pharmacokinetics, pharmacological systems, and (patho-) physiological processes in order to comprehend the intensity and time course of drug effects on the body. As a result, the drug absorption and disposition processes after the administration of these drug delivery systems and engineered molecules become exceedingly complex. The research field of drug delivery focuses on the development of new techniques to manipulate drug absorption and disposition to achieve a desirable effect for the PMX model used. An opportunity to combine pharmacokinetic and pharmacodynamic model-based estimations with pharmacoeconomic models emerges given the unpredictability in the dose-concentration-effect relationship of medications. Model-based drug development (MBDD) has been found to address the underlying causes of medication failure, hence enhancing the productivity, effectiveness, and success of late-stage clinical research. The pharmacokinetic (PK) model principles in optimizing the drug dose to suit individual patient needs and achieving maximum therapeutic utility are called clinical pharmacology. Pharmacodynamics (PD) relates response to the concentration of drugs in the body. Disease progression model-based evaluation of disease progression is an important aspect of drug development and pharmacology. The future perspective of pharmacometrics in drug development and clinical practices is challenging.
An Overview on Analytical Method Development and Validation for Ertugliflozin in Bulk and Pharmaceutical Dosage form
Authors: M. Sagar Priyanka , Mankar S.D. , Dighe S. B.
Published: October 2023

Diabetes mellitus (DM) is a metabolic condition characterized by hyperglycemia, glycosuria, hyperglycemia, a negative nitrogen balance, and occasionally ketonemia. The type 2 sodium-dependent glucose co-transporters (SGLT), which are in charge of roughly 90% of the reabsorption of glucose from the glomerulus, are subject to strong and selective inhibition by ertugliflozin. This review's primary objective is to highlight the development and validation of analytical methods employing chromatographic and spectrophotometric techniques for ertugliflozin and combination products in bulk and pharmaceutical dose forms. RP-HPLC, UV, UPLC, and LC-MS techniques are used to determine the dosage of ertugliflozin when it is combined with metformin and sitagliptin. Spectrometric techniques for ertugliflozin in combination with metformin or sitagliptin contain parameters like solvent, wavelength, linearity, LOD, LOQ, etc., and HPLC methods for ertugliflozin in combination with metformin or sitagliptin include parameters like stationary phase, mobile phase, RT, detection wavelength, LOD, LOQ, etc. Discussions on the separation requirements for ertugliflozin in combination with metformin or sitagliptin are also addressed throughout this review.
A Study to Evaluate the Neuroprotective property of Aqueous Extract of Mentha piperita Leaves on Haloperidol Induced Parkinsonism in Experimental rats
Authors: K L Naveen , Bhattacharjee Ananya , Hegde Karunakar
Published: October 2023

The main objective of the proposed study was designed to investigate the neuroprotective property of aqueous extract of the Mentha piperita leaves (AEMPL) against haloperidol induced Parkinsonism in experimental animals. Rats were divided into 5 groups (n=6 animals). Group 1 received vehicle control, Group 2 received Haloperidol (1mg/kg, i.p.), Group 3receivedstandard drug Sinemet (125mg/kg p.o.), Group4andGroup5treated with lower (100mg/kg, p.o.) and higher (250mg/kg, p.o.) doses of AEMPL respectively for 14 days. Later motor co-ordination (rota-rod), locomotor activity (actophotometer) and catalepsy bar test was performed and also brain histopathological examination was also done. Both the lower and higher doses of aqueous extract of Mentha piperita leaves showed dose dependent, extremely significant increases in locomotor activity by increasing number of cuts, decreases fall off time and also decreases in latency period in metal bar test, histopathological examination shows reduction in neuronal loss and normal brain architecture was observed when compared haloperidol treated group. Hence Mentha piperita shows neuroprotective activity because of potential anti-oxidant property. The obtained result was comparable with that of the standard drug levodopa+carbidopa (Sinemet). The outcome of the present study provides the evidence that the aqueous extract of Mentha piperita leaves reported that it has dose dependent beneficial neuroprotective effect against haloperidol induced Parkinson’s disease in experimental rats.
Synthesis and Anticancer Activity of Bis-Thiosemicarbazone Complexes
Authors: Ashfaq Muhammad Hamza
Published: October 2023

In a present review article, relationships were identified between the structure and activity of the bis-thiosemicarbazone ligands and their zinc and copper complexes. These compounds have different substituents at the diimine point and terminal nitrogen of the backbone. All the copper complexes showed distortion in geometry from square planar while all the zinc complexes showed distortion in geometry from square pyramidal. In electrochemistry determination by cyclic voltammetry, all the copper complexes were found quasi-reversible. When the antiproliferative activity was checked against tumor cells, copper complexes showed the greatest activity. It was seen that antiproliferative activity was decreased when hydrophobic moieties were present at diimine points and terminal nitrogen. Zinc complexes showed the lowest antiproliferative activity because they were failed in ligand delivery intracellularly as they were not chaperone. But cobalt showed good activity by successfully delivering the ligand acting as chaperone1. Copper complexes showed more antiproliferative activity as compared to the ligand. In the environment of the tumor, hypoxia was found which decreased the antiproliferative activity of the ligand and its copper complexes. In the present study, it was concluded that this relationship could be helpful in the synthesis of antitumor agents such as bis-thiosemicarbazone and its complexes.
Prospective Current Novel Drug Target for the Identification of Natural Therapeutic Targets for Alzheimer's Disease
Authors: Kumar Kaman , Singh Pooja , Sharma Divya , Singh Akanksha , Gupta Himanshu , Singh Arjun
Published: October 2023

In today's societies, Alzheimer's disease (AD) is a significant issue. In the US, more than five million people, most of whom are 65 or older, suffer from Alzheimer's disease. By 2060, there will be fourteen million Americans living with Alzheimer's disease, according to a report by the Alzheimer's Association. To find hits with polypharmacological activities, libraries of compounds can be biologically screened based on these targets. These hits can have their structural properties altered to improve the overall profile, just like molecules created using techniques based on knowledge or medicinal chemistry. Designing multi-target ligands against key targets of interest would undoubtedly benefit from knowledge of the roles played by various targets in the development of AD as well as pharmacophores with related biological activities. Computational tools are used to assist in the design of potential polypharmacological lead molecular scaffolds, in addition to knowledge-based and biological screening-based approaches. It is becoming more common to use pharmacophore modelling, machine learning, and structure-based virtual screening to forecast biological activity and target-ligand interaction for various chemical libraries.
Self-Organizing Computational System for Network Anomaly Exploration using Learning Algorithms
Authors: P Preethi , K Lalitha , J Yogapriya
Published: October 2023

The forum in the nation for reporting information security flaws had 14,871 reports by the end of 2021, a 46.6%
increase from 2020. The total of 5,567 high risk vulnerabilities, an increase of nearly 1,400 over the previous year. Evidently,
both the total number of vulnerabilities found annually, and the total number of high-risk vulnerabilities are rising. In order for
data mining technology to play a wider part in the predictive investigation of network security models, it is advised that its
capability have to be improved. This paper combines the concepts of data mining (DM) with machine learning (ML), which
introduces similar technologies from DM technology and security establishing collection channel, thereby finally introduces
the computer network security maintenance process based on data mining in order to improve the application effect of DM in
the predictive analysis of network security models. In this paper, a self-organizing neural network technique that detects denial
of service (DOS) in complicated networks quickly, effectively, and precisely is introduced. It also analyses a number of
frequently employed computer data mining methods, including association, clustering, classification, neural networks,
regression, and web data mining. Finally, it introduces a computer data mining method based on the self-organizing (SO)
algorithm. In comparison to conventional techniques, the SO algorithm-based computer data mining technology is also used in
defensive detection tests against Dos attacks. A detection average accuracy rate of more than 98.56% and a detection average
efficiency gain of more than 20% are demonstrated by experimental data to demonstrate that tests based on the Data Mining
connected SO algorithm have superior defensive detection effects than standard algorithms.
DEVELOPMENT, VALIDATION AND COMPARISON OF RP-HPLC AND UV METHODS USING STATISTICAL ANALYSIS ONE WAY ANOVA TEST FOR REPAGLINIDE IN FORMULATION
Authors:   Department of Pharmaceutical Sciences, Saurashtra University, Rajkot- 360 005, Gujarat, India, Patel Meghna P. , Desai Kushani N. , Sangani Monika
Published: October 2023

In the present study, analytical UV and Rp-HpLC methods for repaglinide were developed for tablet formulation. UV method shows linearity in the range of 10-30 μg mL-1 with a relative coefficient of 0.9999. Linearity is shown in HpLC method in the range of 10- 30 μg mL-1 with a relative coefficient of 0.9985. each method was validated for different validation parameters like specificity, repeatability, accuracy, precision, linearity, robustness, limit of detection and limit of quantification. the results were obtained as per ICH guidelines. The developed UV and HpLC methods were compared with some available methods by statistical analysis one way ANOVA (Analysis of Variance) test, and it was found to be statistically significant
A new-generation approach to PAM-4 Based on the Fano resonance effect using a multimode interference structure
Authors: Do The Duong , Hoang Thanh Nhat , Le Duy Tien , Le Trung Thanh
Published: October 2023

The goal of this research is to come up with a new optical structure for the generation of multilevel pulse amplitude modulation (PAM-4) signalling, which is used for optical interconnects and data center networks. The Fano effect is made with a structure made up of a 4x4 MMI coupler, feedback waveguides, and phase shifters. For the production of PAM-4, we employ the Fano effect. The new proposed approach can reduce power consumption and extend the linear region of the device transfer function compared with conventional approaches based on Mach Zehnder Interferometers (MZI) and ring resonators. We show that an extreme reduction of power consumption of 3 to 30 times, compared with the conventional structure based on MZI and ring resonators, is achieved. In addition, the proposed structure based on silicon wave guides has the advantages of extreme high bandwidth, large fabrication tolerance, and a compact footprint. The proposed structure can be applied to generate the PAM-4 based on the Fano effect with low power consumption, and it is suitable for complex systems with a lot of transceivers. The device is numerically simulated and designed using the Finite Difference Method (FDM) and Finite Difference Time Difference (FDTD). The PAM-4 structure based on silicon waveguides can be compatible with CMOS’s existing technologies.
Investigation of Nitrite Cognition Among College Students
Authors: Wei Xiaozhen , Wei Xiyuan
Published: October 2023

The differences of nitrite cognition among medical students in Guangxi University of Science and Technology were studied. SPSS27.0 software was used for data analysis. There were statistically significant differences in the recognition scores of nitrite among students of different gender, age, education, major and grade (P < 0.05), and the content of nitrite in the tested samples were all within the national safety limit standard. The students surveyed in this study had a high awareness rate of nitrite and poisoning hazards, and different students had different awareness of nitrite.
Design of Portable High Precision Scale Hardness Tester Based on STM32
Authors: Lu Xiaoyu , Li Xiaozhe , Qiu Feng
Published: October 2023

Hardness measurement is a very important index in the process of production and quality inspection. In the past, the precision of portable hardness tester is low, and the stability is poor. Combined with the internal high-speed ADC of the STM32 hardness tester can achieve a more demanding test accuracy requirements. Low power consumption, high accuracy and reliability of data acquisition is realized. And designed with the stemwin library can do more perfect function, human-computer interaction interface is more friendly.
Research on Innovation and Entrepreneurship Education in Vocational Colleges
Authors: Shao Liqun
Published: October 2023

Innovation and entrepreneurship education is an inevitable choice for the education reform of vocational colleges. This article analyzes the necessity of constructing an innovation and entrepreneurship education system in vocational colleges and the problems in innovation and entrepreneurship education in Jiangsu vocational colleges. It proposes to build an innovation and entrepreneurship curriculum system that integrates expertise and innovation, improve the practice system of innovation and entrepreneurship education, and establish an evaluation system for innovation and entrepreneurship education with the characteristics of vocational colleges.
Overflow Intelligent Early Warning System Based on BP Neural Networks
Authors: Yang Yi , Wang Xin , Liu Juanxia
Published: October 2023

Overflow is one of the most serious drilling accidents that affect the safety of drilling construction. The analysis of integrated logging parameters and the judgement of overflow situation in China still remain in the stage of "manual judgement" and "threshold warning". Based on this, we propose the method of combining the real time measurement information of comprehensive logging instrument with artificial intelligence technology, and design a BP neural network based intelligent early warning software system using SQL Server 2008 database management platform and C# program development language. Through the experimental test, the system runs well, the timeliness of overflow early warning is good, the accuracy of early warning results is high, and it can meet the needs of field application, and it can provide effective technical support for the field overflow early warning, and it has a better prospect of field application.
Research and Application of Comprehensive Early Warning System for Coal and Gas Outburst
Authors: Qiao Wei
Published: October 2023

Coal and gas outburst is an extremely complex dynamic phenomenon in the production process of coal mines. In order to further accelerate the intelligent construction of coal mines, taking Xinjing Coal Mine as an example, the online comprehensive analysis and warning indicator system and rules for coal and gas outburst applicable to Xinjing Coal Mine were studied, and a comprehensive warning system for coal and gas outburst in Xinjing Coal Mine was established. Through on-site application, it has been shown that the system has achieved real-time intelligent warning of the danger of outburst in the working face, standardized and dynamic management of outburst prevention information in the working face, as well as real-time dynamic update and sharing of outburst prevention information, improving the efficiency of mine outburst prevention management and the level of mine safety.
Analysis of Influencing Factors of Rural Residential Carbon Emissions Under the Background of Dual Carbon Target
Authors: Li Yang , Zhang Wenyan , Zhang Weiwei
Published: October 2023

This paper studies the carbon emission of rural residential buildings under the background of ' double carbon target '. Based on the characteristics of rural residential buildings and the current situation of carbon emission, the literature research method is used to identify the residential characteristics, enclosure structure, family situation, lifestyle, energy consumption equipment, renewable energy utilization and agricultural production function. The carbon emission influencing factors of 21 rural residential buildings in the use stage of rural residential buildings are helpful to evaluate the carbon emission of buildings more accurately, provide the basis for formulating carbon emission reduction strategies, and promote the sustainable development of rural residential buildings. It is of great significance.
Vibration Control of Marine Flexible Riser with Uncertain Model
Authors: Chen Miaomiao , Zhang Ruihan , Zhou Li , Xiao Shuyu , Zheng Xu , Wu Xueyi
Published: October 2023

When flexible risers in the ocean are subjected to various environmental loads in the ocean, vibration will inevitably occur. Due to the nonlinearity and uncertainty of the actual riser system, it is impossible to obtain an accurate mathematical model of the riser system. The existing control algorithms designed based on the precise model of the riser system cannot meet the actual control requirements. A flexible riser boundary control method based on fuzzy control algorithm is proposed to suppress the vibration of marine flexible riser systems with uncertain models. Firstly, the dynamic models of existing marine flexible risers were studied. In response to the uncertainty of the riser system model, the control experience was transformed into an automatic control strategy in the form of fuzzy language control rules to improve the adaptability of the controller. Then, combining boundary control technology with fuzzy control, a boundary controller is constructed to stabilize the riser in a small neighborhood of its original position and reduce fatigue damage to the riser. Finally, the effectiveness of the designed fuzzy boundary control algorithm was verified through MATLAB simulation results, and the vibration suppression effect of the algorithm on the vertical tube was better than that of traditional PD control.
The reliability Analysis of Microresistivity Scanning Tool Is Based on System Structure
Authors: Zheng Junyuan , Sun Wen , Ren Tao
Published: October 2023

By controlling the position of the logging tool, the system can ensure that it can accurately descend or rise along the hole, and then measure the required formation properties to obtain higher quality formation data. In order to study the structural reliability of microresistivity scanning logging tool, the statics analysis of the microresistivity scanning logging system is carried out first. It is concluded that the maximum total deformation of the microresistivity scanning logging system is 0.04851m and the maximum equivalent stress is 9.387MPa. Secondly, the load and material parameters of each component of the push-pull system are taken as input variables, and the maximum equivalent stress and maximum total deformation are taken as output variables. Through ANSYS Workbench software, the structural strength and stiffness reliability of the push-pull system are analyzed based on Six Sigma theory. Finally, according to the probability distribution table and probability distribution histogram of the input parameters to the output parameters, when the maximum allowable deformation is 0.048519m, the stiffness reliability of the push-rely system structure is 0.98793, and when the maximum allowable stress is 9.387MPa, the structural strength reliability of the push-rely system is 0.96747.
The Formation of the Teapot Effect under Different Forces
Authors: Zeng Zeyu
Published: October 2023

The phenomenon known as the “teapot effect”, which refers to the movement of fluid along the outer wall of a teapot, has garnered significant attention in recent decades within the field of scientific research. Various methods, including the momentum balance method and the hydrodynamic equations, have been utilized to investigate this phenomenon. In this study, we employ a simplified model to examine the influence of different forces on the fluid as it moves along the solid surface. These forces include the adhesive forces between the solid surface and the fluid, the coupling force within the fluid, and gravity. Additionally, we explore the conditions under which the fluid can separate into distinct layers during the teapot effect. Some layers of the fluid may adhere to the outer wall of the teapot, while others may be expelled. The occurrence of this phenomenon is determined by the relative magnitudes of the different forces acting on the fluid. Furthermore, we analyze and calculate the effect’s dependence on velocity. Through our calculations, we contribute to a deeper understanding of how these forces impact the teapot effect.
Two new species in the spider genus Nanometa (Araneae: Tetragnathidae: Nanometinae) from Tasmania
Authors: Castanheira Pedro , Rossi Giullia , Baptista Renner
Published: October 2023

Two new species in the orb-weaving spider genus Nanometa Simon, 1908 are described, N. ilanejzykowiczi sp. nov. and N. cerastes sp. nov. (family Tetragnathidae Menge, 1866), elevating the number of described Australian species to eight. Both new species have so far only been recorded from Hartz Mountains National Park, southern Tasmania, at about 1,200 metres a.s.l., where two other species, N. tasmaniensis Álvarez-Padilla, Kallal & Hormiga, 2020 and N. tetracaena Álvarez-Padilla, Kallal & Hormiga, 2020 also occur.
Corporate Mole: A Grouping Strategy for Minimizing the Free-Rider Problem in a Managerial Finance Course
Authors: Stretcher Robert
Published: October 2023

Group projects in upper level finance courses are becoming common, both for the reflection of real-world group tasks in business firms and for their appropriateness in dealing with certain types of assignments in the classroom and beyond. Professors often lament over effective formation of groups and the task of managing group dynamics, including the problem of free-riders: those students who, knowing that the group gets the grade, will shirk their respective responsibilities in accomplishing group tasks. The following article represents one evolution of grouping methods over two decades and the observations surrounding each. The most successful, in this author’s experience, is a recent marriage of a so-called “reality TV” recipe with structured groupings
A Primer on Financial Calculators
Authors: Mitenko Graham , Maisondieu-Laforge Olivier , Decker Christopher
Published: October 2023

Like it or not, business calculators have become a necessity of every day life for our students. This paper is not meant to condone or condemn the practice of employing calculators to teach a subject (or topic area), but to aid both the teacher and the student in the function and use of financial calculators. The objective of this paper is to test the most popular financial calculators for basic problem solving, accuracy and ease of use. We also present elementary primers to the basic usage of each of the calculators discussed. The primers represent an easy to understand, step by step instruction which could make teaching easier for the instructor and learning easier for the student.
The Finance Professor Teaching an Early Morning Class
Authors: Burrus Robert , Graham Edward , Moffet Clay , Robinson Steve
Published: October 2023

A broad literature affirms the compromised performance of many people in early-morning settings. How does this affirmation manifest itself in the academic environment in general and the finance classroom in particular? We extend the work of disciplines outside the business school and find a need for the finance instructor to anticipate special needs for the early morning class; students in 8:00 classes, relative to 9:30 classes, underperform, and this underperformance is more pronounced for those with jobs. We provide clear evidence of the better performance of the student in the later class that has no outside employment, and extend these findings to a new set of guidelines for use in early morning classes.
Time Value of Money Seminars: Immersion Therapy for Finance Majors
Authors: Followill Richard
Published: October 2023

Finance majors must be able to properly use time-value of money techniques to be academically successful. Recognizing that many of its Finance and Real Estate majors were proceeding beyond their first finance course without an adequate understanding of this crucial skill, the Department of Finance at the University of Northern Iowa instituted a series of voluntary attendance seminars designed to immerse its majors in the mathematics of interest. After four years, the seminars have become an established success, providing most of our majors with the time-value skills necessary to be successful in their academic studies and future careers. This paper tells how these seminars originated and evolved, and offers a roadmap for other finance departments that wish to implement a similar solution for their majors.
Using Library Resource Materials to Integrate Deep Information and Externality Impacts into Semi-Live Finance Case Course Analyses
Authors: Sherman Michael , Martin Julia
Published: October 2023

This paper focuses on the manner in which business library research can be integrated into an upper-level case course in financial management to allow students to study the impact of externalities and what shall be referred to here as “deep information” in examining business decision making. The case class discussed herein analyzes firms contemporaneously, i.e., those facing current financial and operating situations. This differs greatly from traditional case courses that focus instead on historical company situations. In particular, the approach developed at The University of Toledo in its Advanced Financial Management course is examined. Tangentially, the interaction with other courses in the finance curriculum is also discussed.More particularly, the incorporation into the case analysis of the impacts of various factors that are outside of the control of a firm’s management, but that strongly influence and channel its performance, is showcased. Examples of these external factors include the impacts of economic trends and conditions, demographics, international developments, competition, and industry effects. In addition to research on external factors, two other areas in which library assistance can aid in the analysis of concurrent case companies include -- finding data and information that delves more deeply into company activities, e.g., by using corporate and other databases, and utilizing EDGAR to study the footnotes of a firm to uncover obscure and often less comprehensible issues behind its activities and behavior. In doing this, focus is placed upon the manner in which the synergistic efforts of the librarian and case instructor can effectively present and integrate this information into these contemporaneous cases to enhance student learning experience.
Preparing the Statement of Cash Flows Using the Balance Sheet “Squeeze” Spreadsheet
Authors: Matthews Robert , James Joe , Daigle Ronald
Published: October 2023

The statement of cash flows (SCF), established pursuant to Statement of Financial Accounting Standards No. 95 (FAS 95), is perhaps the most useful of the standard financial statements-balance sheet (BS), income statement (IS), and SCF-in evaluating the financial viability of a company, particularly a small business. Unfortunately, the SCF is probably the least understood of the three statements and the most difficult to prepare, and is frequently not included in the financial statement compilations issued by accountants for many small businesses. This paper describes a spreadsheet methodology commonly employed in private industry to facilitate preparation of the SCF, which can be suitable for teaching accounting and finance students at the undergraduate level.
Using Excel Spreadsheets to Teach the Time Value of Money
Authors: Followill Richard , Olsen Brett
Published: October 2023

Possibly the most important precursor of academic success for students of finance is an understanding of the mathematics of interest and the time-value of money. Although a considerable portion of their first finance course is usually devoted to this topic, students often proceed to their advanced courses with inadequate knowledge of this vital subject. In this article, we present and make available Excel spreadsheet templates that provide students with a nearly unlimited collection of problems and solutions to help them efficiently perfect their time-value skills.
El tiempo lineal y el tiempo mítico en La feria, de Juan José Arreola (y otras consideraciones)
Authors: Morales Prado Wendy Lucía
Published: October 2023

Este trabajo presenta un análisis narrativo que resalta dos modalidades temporales de la novela de Juan José Arreola: el tiempo lineal y el tiempo mítico. Ambos se perciben a partir de la fragmentariedad de la novela y tienen distintas finalidades. El tiempo lineal describe el presente de los personajes de Zapotlán, en tanto que el tiempo mítico lo inscribe en el panorama de las gestas revolucionarias del pasado y aún en referencias religiosas. Gracias a estos recursos narrativos, Arreola presenta a Zapotlán el Grande como un lugar en el que suceden simultáneamente muchas historias, la principal la de su padre, pero al mismo tiempo, el sustrato del tiempo mítico inscribe al pueblo en dos confluencias que le dan densidad. Gracias al tiempo mítico su pueblo revive el pasado revolucionario que persiste en él y aún evoca tiempos bíblicos, y así rescata otra concepción importante del tiempo circular a partir de la religiosidad.
De la telepantalla a las redes sociales: la revuelta de Black Lives Matter en 2020
Authors: Escobedo Larisa
Published: October 2023

Análisis de la relación de la historia de la imagen videográfica y fotográfica viral con el devenir de las luchas afroamericanas en los Estados Unidos de América. Los objetivos de la presente investigación son establecer las relaciones que los documentos visuales provocan en las comunidades para su emancipación. La metodología usada será el análisis formal de videos documentales de violencias extremas cometidos por parte de grupos policiales sobre cuerpos de hombres afroamericanos, poniendo énfasis en las transformaciones tecnológicas de grabación, emisión y difusión de los mismos, así como los lenguajes audiovisuales utilizados y su repercusión social. Durante la pandemia de covid-19 en el verano de 2020, se suscitó unas de las mayores manifestaciones contra el racismo sistémico en Estados Unidos. Fueron originadas por el asesinato del afroamericano George Floyd por la policía de los ee.uu. Dicho asesinato fue vídeo grabado con teléfonos celulares y transmitido por redes sociales de manera instantánea. La imagen videográfica se convirtió en el detonador de múltiples fenómenos sociopolíticos que son analizados desde la perspectiva del giro pictorial, recuperando las historias de las luchas por los derechos civiles de los afroamericanos en los siglos xx y xxi a partir de su relación con la imagen.
Procedimientos generales de Fisioterapia - I Electroterapia
Authors: Jiménez Sánchez Carolina , Paula Córdova Alegre , Daniel Sanjuán Sánchez , Beatriz Carpallo Porcar , Alejandro Almenar Arasanz , María Ortiz Lucas , Pablo Gargallo Aguaron , Laura Esteban Repiso , Raquel Lafuente Ureta , Verónica Millán Luna , Mª Pilar López Royo
Published: October 2023

This book presents the theoretical and practical knowledge of electrotherapy based on scientific and clinical findings. It allows students and professionals of physical therapy to understand the theoretical knowledge with a scientific basis that addresses their clinical application through the procedures of the various modalities of electrotherapy.
Occurrence of virulent Serratia marcescens with co-existing antibiotic resistance determinants in ready-to-eat food samples
Authors: Roy Sayani , Wangkheimayum Jayalaxmi , Choudhury Sanchari , Das Bhaskar , Mazumder Pranab , Bhattacharjee Amitabha
Published: October 2023

Background:
Foodborne illness is a global concern and identification of pathogens that cause foodborne disease is a public health priority. Serratia marcescens is an opportunistic pathogen responsible for food poisoning due to its ability to colonize the gastrointestinal surfaces. S. marcescens is also responsible for causing a wide range of extraintestinal infections like pneumonia, urinary tract infection, keratitis, etc.
Aim:
The current study investigated the presence of antibiotic resistant virulent S. marcescens from street food samples.
Methods:
Two pigmented S. marcescens were recovered from Panipuri samples which were then identified using VITEK® GN cards. The virulence genes and the antibiotic resistance genes harboured by the S. marcescens isolates were investigated and further transformation assay was conducted to check the horizontal transferability of the plasmid carrying the antimicrobial resistance genes. Incompatibility typing of the transformants were also assessed and ERIC PCR was performed to check the heterogeneity of the S. marcescens isolates.
Results:
Two S. marcescens isolates harbouring virulence genes as well as antibiotic resistance genes were detected in this study and it was observed that Inc FIB type plasmid was carrying the resistance genes.
Conclusion:
The co-existence of both the virulence and antibiotic resistance genes in the two S. marcescens isolates warrants proper surveillance in order to prevent the spread of such pathogenic strains in environment as well as community through food samples.
Quest for ideal transport conditions and factors affecting revival of Neisseria gonorrhoeae isolates: Experience of a National Reference Laboratory
Authors: Kirti Madhavi , Muralidhar Sumathi , Lachyan Abhishek , Sharma Devanshi , Joshi Naveen , Khunger Niti
Published: October 2023

Background:
Neisseria gonorrhoeae (Gonococcus-GC) is a fastidious, autolytic Gram-negative diplococcus with stringent growth requirements, and cannot be cultivated in a routine microbiology laboratory, without well-equipped incubators, reagents and special media. Hence, many clinics and laboratories prefer to ship the specimens or isolates to a dedicated referral laboratory for confirmation of isolates and the antimicrobial susceptibility testing. Thus, transportation conditions for gonococcal isolates, become crucial for its recovery and successful isolation in the laboratory. This retrospective study was conducted at a national referral laboratory for gonococcus, in India, over a period of three years.
Aim:
In this study, an attempt was made to determine the factors affecting revival of isolates of gonococci, that were despatched, from across India, to the referral laboratory for confirmation of species and antimicrobial susceptibility patterns.
Method:
Over a three-year period, the culture plates, test tubes or vials used for transporting gonococcal isolates, and their modes of transport to referral laboratory, were studied in detail. The isolates were revived (whenever possible), sub cultured and identified by standard methods in the referral laboratory.
Results:
A total of 77 samples were processed for revival and 83.12 % of isolates were recovered, with failure of recovery in 16.88 % of specimens.
Conclusion:
Several factors play a role in the successful revival of Neisseria gonorrhoeae from culture isolates transported across the Indian subcontinent. These include- purity of growth, culture media used for transport, sending of isolates in duplicates, temperature, time, distance and season of transport. All these factors must be kept in mind when transporting gonococcal isolates, for successful revival. Finally, the skills of the laboratory technician are of immense importance too.
Assessment of thyroid function and biochemical markers among COVID-19 Libyan patients
Authors: Omar Mouna , Rayes Abdunnabi , Alkmishi Nagat , Elaswad Firuz , Younes Hanadi , Ghisheer Munay , Fadli Ibtehal , Dayhum Abdunaser , Eldaghayes Ibrahim
Published: October 2023

Background:
There is a scarcity of data on thyroid function abnormality in coronavirus disease 2019 (COVID-19) outpatients in the world literature since previous studies were done on admitted patients.
Aim:
The objective of this study was to assess thyroid function tests (TFT) in Libyan outpatients with COVID-19 as well as the possible association between them and some routine hematological, inflammatory and biochemical markers.
Methods:
Laboratory results were retrospectively reviewed for a total number of 246 patients, where 214 patients with laboratory-confirmed COVID-19 and 32 non-COVID-19 patients were included in the study as a control group. The majority of the patients were females 179 (72.8%) and age range between 18 and 88 years old. They were registered in the outpatient department of COVID-19 at Zaweit-Dahmany Polyclinic in Tripoli, Libya between May and October 2021. Serum levels of thyroid-stimulating hormone (TSH), thyroid hormones (THs) (triiodothyronine (T3), thyroxine (T4), and free fractions), complete blood count (CBC), C-reactive protein (CRP), lactate dehydrogenase (LDH), liver function test (LFT), and renal function test (RFT) were measured.
Results:
Abnormal thyroid function was seen in 17.8% of 214 patients with COVID-19. Twelve patients had isolated low total or free triiodothyronine (FT3), suggestive of nonthyroidal illness syndrome (NTIS), ten patients had hypothyroidism that was subclinical in six patients and overt in the remaining four patients. Three patients had hyperthyroidism. Thirteen patients had different isolated THs abnormalities. Low FT3 was associated with older age (P= 0.035), and it has a weak negative correlation with CRP (-0.335) and LDH (-0.245) (P= 0.001). The thyroid dysfunction (TD) group presented a statistically significant reduction in lymphocytes (P= 0.000), increased neutrophil (P= 0.000), increased CRP (P= 0.000), increased urea (P= 0.014), increased alkaline phosphatase (ALP) (P= 0.007), a slight reduction in hematocrit (HCT) (P= 0.010), low mean corpuscular volume (MCV) (P= 0.019), and low mean corpuscular hemoglobin (MCH) (P= 0.019) but no significant difference in hemoglobin (Hb), red blood cells (RBC), white blood cells (WBC), and platelet count when compared to euthyroid control.
Conclusion:
Clinicians should be vigilant about the possible presence of thyroid function abnormalities among COVID-19 patients, especially elderly patients, and those with increased inflammatory markers.
Burkholderia cepacia complex (BCC) causing bacteremia in patients suffering from B-cell acute lymphocytic leukemia: A case report
Authors: Kar Mitra , Dubey Akanksha , Singh Romya , Sahu Chinmoy , Patel Sangram , Fatima Nida
Published: October 2023

Background:
Burkholderia cepacia complex consists of 24 species of microorganisms that include B. cepacia, B. multivorans, B. cenocepacia, B. vietnamiensis, B. ambifaria, and many more. It is a ubiquitous microorganism found in the soil and aquatic milieu. The most common infections caused by these isolates include bacteremia, pneumonia, genital tract infections, and surgical wound infections. Their potential to cause nosocomial outbreaks in wards of immunocompromised patients is well known.
Case Description:
In this case report, we describe two cases of community-acquired B. vietnamese bacteremia in patients suffering from B-cell acute lymphocytic leukemia and their antibiotic sensitivity pattern to guide the treatment of these individuals.
Conclusion:
The identification of rare opportunistic pathogens like Burkholderia vietnamese and adequate treatment in the pandemic-ridden era is the need of the hour due to a rise in immunocompromised conditions owing to the rigorous use of antimicrobials and steroids.
Catchment controls on mire properties in the post-glacial landscape
Authors: Ehnvall Betty
Published: October 2023

Mires are key ecosystems in the boreal biome which provide services related to carbon uptake, biodiversity, and regulation of hydrological and biogeochemical cycles. Minerogenic mires are supported by their upslope catchment area and underlying mineral soil, but a more detailed understanding and quantification of landscape drivers behind mire properties is needed. My thesis is focused on catchment controls on mire vegetation, and peat accumulation and expansion rates. The study was conducted in the Sävar Rising Coastline Mire Chronosequence in northern Sweden, where strong isostatic rebound has formed a natural age gradient that can be used for landscape level studies covering the Holocene. Given the similar climate, bedrock, and mineral soil properties across the area, the role of catchment eco-hydrological settings can be distinguished from that of mire ageing. Our results show that mire vegetation and recent nitrogen accumulation rates responded to catchment nutrient support, but older mires with deeper peat were also associated with lower plant productivity. In contrast, recent peat and carbon accumulation rates increased with mire age and a lower catchment supply of nutrients. The increase in peat and carbon accumulation rates with mire age was faster in hummocks than lawns, and after four thousand years hummock accumulation rates exceeded those in lawns. Mires in the area expanded non-linearly across the landscape depending on the availability of suitably wet areas. Mires occupied the wettest locations within one to two thousand years after land exposure and the slightly drier areas within three to four thousand years. Except for mires younger than a thousand years old, mire abundance was controlled by topography, while total mire area increase was a function of time and the formation of larger mire complexes. The results of this thesis contribute to the understanding of mire development at high latitudes and to scaling up our understanding of mire properties to the wider landscape level.
Taklik Talak Dalam Perspektif Fiqh Syafi’iyyah Dan Hukum Positif
Authors: Safrizal Safrizal
Published: October 2023

Penelitian ini mengkaji penetapan taklik talak dan perbedaannya menurut Fiqh Syafi’iyyah dan Hukum Positif.  Metode yang digunakan dalam penelitian ini adalah penelitian komparatif bersifat  deskriptif,  yaitu penelitian yang membandingkan dua atau lebih kejadian dengan melihat penyebabnya, metode pengumpulan data yang digunakan adalah dengan menelaah dan menyeleksi konsep-konsep atau hasil penelitian yang relevan. Hasil penelitian maka dapat disimpulkan bahwa taklik tala boleh dan talak akan jatuh jika melanggar taklik talak yang telah ditetapkan menurut Fiqh Syafi’iyyah, sedangkan Hukum Positif Tidak, permasalahan taklik talak dalam Hukum Positif merujuk kepada Undang-Undang Pasal 66 ayat (1)  No 1 Tahun 1974 yaitu talak adalah permohonan yang diajukan oleh suami kepada pengadilan agama guna menceraikan istrinya denganpenyaksian ikrar talak.
Penegakan Hukum Judi Online Chip Domino Yang Dilakukan Oleh Wilayatul Hisbah Ditinjau Dari Qanun No. 13 Tahun 2003 Tentang Maisir
Authors: Soraya Ade
Published: October 2023

Enforcement of online gambling by Wilayatul Hisbah as stipulated in Article 15 Paragraph (3) in Qanun Number 13 of 2003 concerning Maisir (gambling) states that "In carrying out the coaching function, Wilayatul Hisbah officials who find perpetrators of finger maisir can give warnings and guidance in advance to offender before handing them over to investigators. From this article it can be interpreted that the Wilayatul Hisbah has the authority to arrest the perpetrators of maisir. Even though it has been regulated in such a way, both in statutory regulations, Aceh Qanun Number 13 of 2003, as well as Qanun No. 6 of 2014 concerning Jinayah Law. The Wilayatul Hisbah law enforcement apparatus is still vacillating in carrying out its functions, because there are two investigators in the Maisir Qanun, namely Wilayatul Hisbah investigators (PPNS) and Police investigators. Eradication of gambling is not something that can be easily eliminated, it is necessary to have legal regulations that take strict action against the perpetrators of gambling crimes. Regulations for gambling were originally regulated in Article 542 of the Criminal Code, but based on the provisions stipulated in Article 2 paragraph (4) of Law no. 7 of 1974 concerning Controlling Gambling, has been amended in the criminal provisions in Article 303 bis of the Criminal Code.
Pemanfaatan Perkembangan Teknologi Informasi Dan Komunikasi Untuk Meningkatkan Mutu Dakwah
Authors: Alamsyah Muhibuddin
Published: October 2023

Kajian ini bertujuan untuk menggambarkan tentang pemanfaatan perkembangan teknologi informasi dan komunikasi untuk meningkatkan mutu dakwah. Ini termasuk kajian library research. Dalam kajian ini ditemukan bahwa Perkembangan teknologi informasi dan komunikasi membawa banyak manfaat bagi manusia, seperti mempermudah akses ilmu pengetahuan dan membuka peluang untuk inovasi di berbagai bidang seperti pendidikan, ekonomi, dan pemerintahan. Terdapat pandangan negatif terhadap dampak teknologi, tetapi dampak positifnya lebih besar karena teknologi ini dapat meningkatkan kualitas komunikasi dan memfasilitasi proses inovasi antarwarga masyarakat. Selain itu, teknologi ini juga dapat digunakan untuk meningkatkan kualitas dakwah dengan memilih media yang tepat untuk menyampaikan pesan yang mampu merubah prilaku khalayak. Perkembangan teknologi ini juga bisa untu meningkatkan mutu dakwah bagi para da’i yang telah mampu menguasai media ini. Dengan perkembangan teknologi para da’i juga bisa memilih media mana yang cocok untuk menyampaikan pesan-pesan dakwah yang mampu merubah prilaku para khalayak sesuai dengan harapan.