bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
Authors: Chen Jungang , Song Jiao , Plaisance-Bonstaff Karlie , Mu Shengyu , Post Steven R. , Dai Lu , Qin Zhiqiang
Published: April 2023

Although Kaposi’s sarcoma-associated herpesvirus (KSHV) has been reported to cause several human cancers including Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL), the mechanisms of KSHV-induced tumorigenesis, especially virus–host interaction network, are still not completely understood, which therefore hinders the development of effective therapies. Histamine, together with its receptors, plays an important role in various allergic diseases by regulating different inflammation and immune responses. Our previous data showed that antagonists targeting histamine receptors effectively repressed KSHV lytic replication. In the current study, we determined that histamine treatment increased cell proliferation and anchorage-independent growth abilities of KSHV-infected cells. Furthermore, histamine treatment affected the expression of some inflammatory factors from KSHV-infected cells. For clinical relevance, several histamine receptors were highly expressed in AIDS-KS tissues when compared to normal skin tissues. We determined that histamine treatment promoted KSHV-infected lymphoma progression in immunocompromised mice models. Therefore, besides viral replication, our data indicate that the histamine and related signaling are also involved in other functions of KSHV pathogenesis and oncogenesis.
Immunogenicity and In Vivo Protective Effects of Recombinant Nucleocapsid-Based SARS-CoV-2 Vaccine Convacell®
Authors: Rabdano Sevastyan O. , Ruzanova Ellina A. , Pletyukhina Iuliia V. , Saveliev Nikita S. , Kryshen Kirill L. , Katelnikova Anastasiia E. , Beltyukov Petr P. , Fakhretdinova Liliya N. , Safi Ariana S. , Rudakov German O. , Arakelov Sergei A. , Andreev Igor V. , Kofiadi Ilya A. , Khaitov Musa R. , Valenta Rudolf , Kryuchko Daria S. , Berzin Igor A. , Belozerova Natalia S. , Evtushenko Anatoly E. , Truhin Viktor P. , Skvortsova Veronika I.
Published: April 2023

The vast majority of SARS-CoV-2 vaccines which are licensed or under development focus on the spike (S) protein and its receptor binding domain (RBD). However, the S protein shows considerable sequence variations among variants of concern. The aim of this study was to develop and characterize a SARS-CoV-2 vaccine targeting the highly conserved nucleocapsid (N) protein. Recombinant N protein was expressed in Escherichia coli, purified to homogeneity by chromatography and characterized by SDS-PAGE, immunoblotting, mass spectrometry, dynamic light scattering and differential scanning calorimetry. The vaccine, formulated as a squalane-based emulsion, was used to immunize Balb/c mice and NOD SCID gamma (NSG) mice engrafted with human PBMCs, rabbits and marmoset monkeys. Safety and immunogenicity of the vaccine was assessed via ELISA, cytokine titer assays and CFSE dilution assays. The protective effect of the vaccine was studied in SARS-CoV-2-infected Syrian hamsters. Immunization induced sustainable N-specific IgG responses and an N-specific mixed Th1/Th2 cytokine response. In marmoset monkeys, an N-specific CD4+/CD8+ T cell response was observed. Vaccinated Syrian hamsters showed reduced lung histopathology, lower virus proliferation, lower lung weight relative to the body, and faster body weight recovery. Convacell® thus is shown to be effective and may augment the existing armamentarium of vaccines against COVID-19.
Inter-Subject EEG Synchronization during a Cooperative Motor Task in a Shared Mixed-Reality Environment
Authors: Ogawa Yutaro , Shimada Sotaro
Published: April 2023

Mixed-reality (MR) environments, in which virtual objects are overlaid on the real environment and shared with peers by wearing a transparent optical head-mounted display, are considered to be well suited for collaborative work. However, no studies have been conducted to provide neuroscientific evidence of its effectiveness. In contrast, inter-brain synchronization has been repeatedly observed in cooperative tasks and can be used as an index of the quality of cooperation. In this study, we used electroencephalography (EEG) to simultaneously measure the brain activity of pairs of participants, a technique known as hyperscanning, during a cooperative motor task to investigate whether inter-brain synchronization would be also observed in a shared MR environment. The participants were presented with virtual building blocks to grasp and build up an object cooperatively with a partner or individually. We found that inter-brain synchronization in the cooperative condition was stronger than that in the individual condition (F(1, 15) = 4.70, p < 0.05). In addition, there was a significant correlation between task performance and inter-brain synchronization in the cooperative condition (rs = 0.523, p < 0.05). Therefore, the shared MR environment was sufficiently effective to evoke inter-brain synchronization, which reflects the quality of cooperation. This study offers a promising neuroscientific method to objectively measure the effectiveness of MR technology.
Distribution of Antibiotic Resistance Genes and Their Association with Microbes in Wastewater Treatment Plants: A Metagenomics Analysis
Authors: Shen Mengnan , Hu Xiaowei , Li Ming , Lyu Chen , Hu Yi , Bu Xiaodan , Chen Tao , Cai Hang , Li Chenyang , Liu Jiahong , Fan Kai
Published: April 2023

The extensive use of antibiotics has resulted in the generation and accumulation of antibiotic resistance genes (ARGs) in the environment, and domestic wastewater is one of the main reservoirs of ARGs and resistant bacteria. In this study, Illumina high-throughput sequencing and network analysis were used to study the microbial community characteristics, ARGs’ occurrence status, and resistance mechanism in the influent and effluent of a domestic sewage treatment plant in Changchun, China. A total of 29 phyla were found in the influent and effluent, including 23 bacterial phyla, 3 archaeal phyla, and 3 eukaryotic phyla. In total, 112 ARG subtypes were detected in the samples, and the dominant ARG subtypes were Erm(35) and tet(W/N/W). In this study, ARGs related to tetracycline and macrolide accounted for a high proportion, and the resistance mechanisms of ARGs detected in the samples were mainly antibiotic inactivation and antibiotic efflux pumps. Co-occurrence maps of ARGs and microbes demonstrated by network analysis indicated that the resistance genes kdpE, GES-5, and tetX may easily bind to microbes, potentially making them antibiotic-resistant bacteria. Fifty-seven bacteria in the genera Cupriavidus, Escherichia, and Collinsell are potential hosts of multiple ARGs. The findings can increase our understanding of the distribution of ARGs and their association with microbes in wastewater treatment plants, and also provide a research foundation for controlling the diffusion of ARGs in the environment.
Proposed Countermeasures against Woody Debris Damage Considering Runoff Characteristics
Authors: Harada Norio , Kimura Ichiro , Satofuka Yoshifumi , Mizuyama Takahisa
Published: April 2023

In recent years, a combination of forestry decline and global climate change has led to heavy rains and landslides in Japan that have caused extensive forest damage through woody debris outflow. The current configuration of impermeable sabo dams has insufficient capacity to capture woody debris under these conditions; therefore, improvements to permeable sabo dams, which have a high woody debris capture capacity, are underway; these sometimes involve the addition of steel fittings. In this study, we examined the effectiveness of such measures in consideration of the factors affecting woody debris flow. After reviewing a woody debris outflow that occurred during a heavy rain disaster in northern Kyushu, Japan, we propose woody debris countermeasures that consider basin and runoff characteristics. Our results indicate that woody debris flow occurs later than sediment flow. Therefore, we performed experiments to test the effectiveness of various methods to slow water flow using the terrain conditions at the nearest valley outflow point. Finally, we propose woody debris countermeasure policies considering basin characteristics, to promote the future preservation of river basins.
Assessing the Effect of Conduit Pattern and Type of Recharge on the Karst Spring Hydrograph: A Synthetic Modeling Approach
Authors: Ostad Hadi , Mohammadi Zargham , Fiorillo Francesco
Published: April 2023

It is widely accepted that spring hydrographs are an effective tool for evaluating the internal structure of karst aquifers because they depict the response of the whole aquifer to recharge events. The spring hydrograph is affected by various factors such as flow regime, geometry, type of recharge, and hydraulic properties of conduit. However, the effect of conduit network geometry received less attention and required more comprehensive research studies. The present study attempted to highlight the impact of the two most frequent patterns of karst conduits (i.e., branchwork and network maze) on the characteristic of the spring hydrograph. Therefore, two conduit patterns, branchwork and network maze, were randomly generated with MATLAB codes. Then, MODFLOW-CFP was used to quantify the effect of conduit pattern, conduit density, and diffuse or concentrated recharge on the spring hydrograph. Results reveal that peak discharge, fast-flow recession coefficient, and the return time to baseflow are mainly affected by conduit network pattern, conduit network density, and recharge, respectively. In contrast, the time to reach peak flow only reacts to recharge conditions. Large variations in conduit density produce tangible changes in the baseflow recession coefficient.
Cyanide Biodegradation by a Native Bacterial Consortium and Its Potential for Goldmine Tailing Biotreatment
Authors: Alvarado-López María José , Garrido-Hoyos Sofía E. , Raynal-Gutiérrez María Elena , El-Kassis Elie G. , Luque-Almagro Víctor M. , Rosano-Ortega Genoveva
Published: April 2023

A native cyanide-degrading bacterial consortium was isolated from goldmine tailing sediments. Mine tailings are toxic effluents due to their metal–cyanide complexes. The bacterial consortium was able to degrade an initial sodium cyanide concentration ranging from 5 to 120 mg L−1 in alkaline synthetic wastewater (pH > 9.2), for a maximum of 15 days. The free cyanide biodegradation efficiency was 98% for the highest initial free cyanide concentration tested and followed a first-order kinetic profile, with an estimated kinetic rate constant of 0.12 ± 0.011 d−1. The cyanide-degrading consortium was streaked with serial dilutions on a specific medium (R2A). 16S rRNA gene sequencing and mass spectrometry proteomic fingerprinting of the isolates showed that the bacterial strains belonged to Microbacterium paraoxydans, Brevibacterium casei, Brevundimonas vesicularis, Bacillus cereus and Cellulosimicrobium sp. The first four genera had previously been identified as cyanide-degrading bacteria. Microbacterium and Brevibacterium had previously been found in alkaline conditions, showing resistance to heavy metals. As for Cellulosimicrobium, to our knowledge, this is the first study to implicate it directly or indirectly in cyanide biodegradation. In this research, these genera were identified as functional bacteria for cyanide degradation, and they might be suitable for mine tailing biotechnological tertiary treatment.
An Analysis of Microplastics Ingested by the Mediterranean Detritivore Holothuria tubulosa (Echinodermata: Holothuroidea) Sheds Light on Patterns of Contaminant Distribution in Different Marine Areas
Authors: Martines Alessandra , Furfaro Giulia , Solca Michele , Muzzi Maurizio , Di Giulio Andrea , Rossi Sergio
Published: April 2023

Microplastic pollution constitutes a serious environmental problem that requires more effective scientific research to describe its potential impacts on marine fauna. The interaction between microplastics and marine biota can have significant negative effects through the trophic chain, up to human health. To date, several steps forward have been made in our understanding of this phenomenon; however, large knowledge gaps still exist for several taxa and areas. In particular, the pattern of spatial and temporal distribution of microplastics in marine sediments and their interaction with benthic detritivore species still needs to be addressed. The Mediterranean Sea is one of the most impacted areas of the world, and its biota is deeply affected by microplastic pollution. To investigate the effects of the presence of microplastics in the sediments in this area, the echinoderm Holothuria tubulosa was chosen as a model species, and specimens were collected along the Salento peninsula in Apulia, Southern Italy. This peculiar geographic area extends between two ecoregions of the Mediterranean Sea, the Northern Ionian and the Southern Adriatic seas, characterized by peculiar and distinct currents and submarine topologies, resulting in a complex and dynamic ecosystem affected by seasonal fluctuations that make the Salento peninsula an interesting natural laboratory for predictions of future dispersion events on a wider scale. Microplastics were analyzed by investigating the gut contents of H. tubulosa individuals, and the SEM/EDX method was used to confirm the plastic material extracted. Results revealed microplastics in all the specimens analyzed and with a homogeneous pattern of distribution in time and some differences in space, suggesting that the presence of this anthropogenic material is constant throughout the year and its quantity is only slightly affected by the level of conservation and management strategies characterizing the sampling sites.
Numerical Investigation of the Stress on a Cylinder Exerted by a Stratified Current Flowing on Uneven Ground
Authors: Wang Yin , Xu Ming , Wang Lingling , Shi Sha , Zhang Chenhui , Wu Xiaobin , Wang Hua , Xiong Xiahui , Wang Chunling
Published: April 2023

In this study, a three-dimensional internal wave (IW)—cylinder—terrain coupled numerical model is established. Based on the large-eddy simulation (LES) method, the IW mechanical characteristics of the cylinder and the flow field evolution around the cylinder over different types of terrains are explored. The similarities and differences in the mechanical characteristics of the cylinders in the environments with and without terrains are compared. The research results show that, when the IWs propagate over terrain, the waveform structures are prone to continuous changes. The intense reverse alternating flow of the upper and the lower water, bounded by the pycnocline, results in huge IWs forces differences between the case without terrains and the cases with terrains. In the case without terrains, the maximum horizontal resultant force on the cylinder is positive, while the resultant forces are negative in the cases with terrain. Compared with the case without terrain, the shallow-water effect caused by the combined action of the terrain and the IWs enhances the flow field strength, making the lower parts of the cylinder suffer larger horizontal forces in the opposite direction to the IW direction. Moreover, the additional vortices produced by the interaction between the IWs and the terrain causes a more complex flow field around the cylinder and the greater forces on the cylinder.
Exploring Multiscale Variability in Groundwater Quality: A Comparative Analysis of Spatial and Temporal Patterns via Clustering
Authors: Mohsine Ismail , Kacimi Ilias , Abraham Shiny , Valles Vincent , Barbiero Laurent , Dassonville Fabrice , Bahaj Tarik , Kassou Nadia , Touiouine Abdessamad , Jabrane Meryem , Touzani Meryem , El Mahrad Badr , Bouramtane Tarik
Published: April 2023

Defining homogeneous units to optimize the monitoring and management of groundwater is a key challenge for organizations responsible for the protection of water for human consumption. However, the number of groundwater bodies (GWBs) is too large for targeted monitoring and recommendations. This study, carried out in the Provence-Alpes-Côte d’Azur region of France, is based on the intersection of two databases, one grouping together the physicochemical and bacteriological analyses of water and the other delimiting the boundaries of groundwater bodies. The extracted dataset contains 8627 measurements from 1143 observation points distributed over 63 GWB. Data conditioning through logarithmic transformation, dimensional reduction through principal component analysis, and hierarchical classification allows the grouping of GWBs into 11 homogeneous clusters. The fractions of unexplained variance (FUV) and ANOVA R2 were calculated to assess the performance of the method at each scale. For example, for the total dissolved load (TDS) parameter, the temporal variance was quantified at 0.36 and the clustering causes a loss of information with an R2 going from 0.63 to 0.4 from the scale of the sampling point to that of the GWB cluster. The results show that the logarithmic transformation reduces the effect of outliers and improves the quality of the GWB clustering. The groups of GWBs are homogeneous and clearly distinguishable from each other. The results can be used to define specific management and protection strategies for each group. The study also highlights the need to take into account the temporal variability of groundwater quality when implementing monitoring and management programs.
Lista de árbitros, Volumen 4
Authors: Editorial Equipo
Published: April 2023

Lista de árbitros, Volumen 4

Colaboradores responsables del volumen
Uso de reservas energéticas durante la primera madurez sexual en laboratorio de la concha nácar Pteria sterna con dietas enriquecidas con glúcidos y lípidos
Authors: Mazón-Suástegui José Manuel , Hernández López Cristal , Arrieche Dwight , Lodeiros César , Freites Luis , Saucedo Pedro E.
Published: April 2023

Se evaluó el uso de las reservas energéticas de reproductores juveniles de Pteria sterna (50 mm de altura; 9 meses de edad) durante su primera madurez sexual en condiciones de laboratorio. Se empleó una dieta microalgal base (Dieta M) complementada con fécula de maíz rica en carbohidratos (dietas F1 y F2) y con microcápsulas ricas en lípidos (dietas L1 y L2), equivalente a una ración diaria del 1 y 2 % de la biomasa seca de tejidos blandos. Se hicieron muestreos a los días 0 (d0), 15 (d15) y 30 (d30) para recolectar tejidos y determinar las variaciones temporales en el índice de tejido gonadal (ITG, %), diámetro teórico de ovocitos (DT, µm) y composición bioquímica de carbohidratos, proteínas y lípidos en la gónada, glándula digestiva, músculo y manto (mg/g). Debido a la talla de los organismos y carácter protándrico de la especie, los machos dominaron sobre las hembras en todos muestreos. Al d30, los organismos maduraron en diferente proporción dependiendo del sexo y dieta, siendo el ITG significativamente mayor en machos y hembras que se alimentaron con la dieta L1, y el DT de ovocitos significativamente mayor en las hembras de la dieta L2. La concentración de carbohidratos del músculo aductor y gónada disminuyó significativamente en ambos muestreos (d15 y d30) y en casi todas las dietas (excepto F2); esto sugiere un proceso de lipogénesis a partir de este combustible en ambos tejidos, particularmente en el músculo, lo que a su vez explica el incremento en los niveles de lípidos en la gónada al d30 en las ostras de las dietas L1 y L2. El contenido de lípidos de la glándula digestiva disminuyó significativamente al d30 con casi todas las dietas (a excepción de L2), indicando que este tejido moviliza a la gónada lípidos previamente almacenados para asegurar la maduración de gametos. La dieta L2 parece la mejor alternativa, incluso combinada con la dieta F2, para la maduración sexual de P. sterna, con resultados que podrían estar asociados a su actividad gametogénica inicial protándrica.
La música tradicional ecuatoriana como elemento fortalecedor de la identidad cultural en estudiantes de quinto año de educación básica
Authors: Niño De Guzmán Soria Gary Omar , González-Martínez Elier
Published: April 2023

El presente artículo tiene como finalidad valorar la importancia de la música tradicional ecuatoriana como elemento fortalecedor de identidad cultural dentro del proceso educativo enseñanza aprendizaje en la materia de Educación cultural artística. El estudio se realizó con un enfoque cualitativo en la investigación a través de entrevistas realizadas a una muestra de docentes profesionales de la especialidad de educación musical y artistas de música tradicional. Como principales resultados a destacar, se evidenció que la música tradicional es una estrategia imprescindible y benéfica en el desarrollo de la identidad de los estudiantes en el proceso educativo. Se presenta como un recurso didáctico que abre un amplio espacio de oportunidades para una mejor comprensión y valoración del nuestro patrimonio inmaterial. Sin embargo, la presencia de la música dentro del actual currículo de Educación cultural y artística es muy limitado, dejando inconcluso el proceso de aprendizaje significativo en la conciencia del alumnado hacia la cultura e identidad ecuatoriana. 
PALABRAS CLAVE: Música tradicional; Identidad cultural; Estrategias de enseñanza musical.
Traditional ecuadorian music as a strengthening element of cultural identity in students in the fifth year of basic education
ABSTRACT
The purpose of this article is to highlight and value the importance of Ecuadorian traditional music as a strengthening element of cultural identity within the educational teaching-learning process in the field of artistic Cultural Education. It also seeks to generate its impact on fifth grade students of Basic Education through cultural mechanisms that complement development. Integral the study was based on a qualitative research, through interviews carried out in a sample of nine professionals between teachers of the specialty of music education and traditional music artists. Through the results obtained I intend to show that students will learn more about the varieties of traditional musical rhythms of Ecuador through pedagogical strategies such as motivation and constant instrumental practice. In this way, it is possible to increase the degree of affinity and taste of the student for traditional Ecuadorian rhythms. The conclusions of this work are that traditional music is an essential and beneficial strategy in the development of identity in the educational process. Such is the case that as a didactic resource it opens a wide space of opportunities for a better understanding and appreciation of our intangible heritage. However, the presence of music within the current cultural and artistic education curriculum is very limited, leaving the meaningful learning process unfinished in the students' awareness of Ecuadorian culture and identity. 
KEYWORDS: Traditional music; Cultural identity ; Musical teaching strategies.
Programación con ScratchJr en el desarrollo de la construcción del número
Authors: Merino Morales Evelyn Lizbeth , Monar Zambrano Melanie Melissa , Analuisa Maiguashca Jessica Carolina , Larrea Astudillo Nelly Carolina , Cruz Báez Estefanía Rocío
Published: April 2023

El avance de la tecnología ha permitido aplicar nuevas estrategias pedagógicas en el ámbito educativo para favorecer el aprendizaje de las relaciones lógico-matemáticas. Por lo tanto, la presente investigación se ha llevado a cabo por medio de la implementación de un curso virtual que tuvo como objetivo determinar la incidencia del software ScratchJr, como estrategia pedagógica para el desarrollo de la construcción del número en niños de primero de básica. El diseño de investigación fue no experimental y de tipo descriptivo, el tipo de muestra fue no probabilística por conveniencia con el fin de obtener validez en la recopilación de información. Se aplicó el Test de Evaluación Matemática Temprana (TEMT) en dos momentos (Pre y post test) durante el estudio. Es así que, los estudiantes presentan mayor motivación para adquirir conocimientos matemáticos tempranos. De tal modo que se aceptó la hipótesis alternativa; los infantes alcanzaron en el post test calificaciones mayores a las registradas durante la aplicación del pre test en cada una de las nociones. Además, muestra la efectividad del entorno de programación infantil ScratchJr en el proceso de enseñanza-aprendizaje en el concepto del número, puesto que en un futuro niños y niñas serán capaces de aplicar conocimientos obtenidos para resolver problemas matemáticos en su diario vivir.
PALABRAS CLAVE: ScratchJr; programación; construcción del número; noción.
Programming with ScratchJr in the development of the construction of the number
ABSTRACT
The advancement of technology has made it possible to apply new pedagogical strategies in the educational field to favor the learning of mathematical logical relationships. Therefore, this research has been carried out through the implementation of a virtual course that aimed to determine the incidence of the ScratchJr software, as a pedagogical strategy for the development of number construction in first-grade children. The research design was non-experimental and descriptive, the type of sample was non-probabilistic for convenience to obtain validity in the collection of information. The Early Mathematical Evaluation Test (TEMT) was applied in two moments (Pre and post-test) during the study. Thus, students are more motivated to acquire early mathematical knowledge. In such a way that the alternative hypothesis is accepted; The infants achieved higher scores in the post-test than those recorded during the pre-test application in each of the notions. In addition, it shows the effectiveness of the ScratchJr children's programming environment in the teaching-learning process in the concept of numbers, since in the future children will be able to apply knowledge obtained to solve mathematical problems in their daily lives.
KEYWORDS: ScratchJr; programming; construction of the number; notion.
Inteligencia artificial vs.Turnitin: implicaciones para el plagio académico
Authors: Díaz Arce Dariel
Published: April 2023

El presente trabajo busca evaluar la utilidad de Turnitin para identificar trabajos realizados por herramientas de Inteligencia Artificial. El diseño fue experimental con dos grupos, uno experimental formado por 50 ensayos creados por ChatGPT y otro control, formado por 50 trabajos de los mismos temas creados por estudiantes de bachillerato. Se contrastaron los índices generales de similitud (IGS), la frecuencia de trabajos en riesgo de plagio (IGS ≥14 %) y la frecuencia trabajos con signos de plagio por copy-paste después de la revisión manual. El IGS promedio resultó ser mayor en los documentos entregados por los estudiantes (33 % vs. 19 % en ChatGPT). Aunque la frecuencia de trabajos en riesgo fue similar, la revisión manual solo pudo detectar el 24 % en aquellos creados por IA, respecto al 56 % de los realizados por los alumnos. Estos resultados plantean interrogantes sobre la utilidad de los programas “antiplagio” ante la nueva ola de herramientas digitales de generación de contenidos que puedan conducir a dilemas ético-legales referidos al derecho de autor, siendo el plagio IA el tema a debatir.
PALABRAS CLAVE: plagio académico; ciberplagio; inteligencia artificial; herramientas antiplagio; educación.
Artificial intelligence vs. Turnitin: implications for academic plagiarism
ABSTRACT
The objective of this work was to evaluate the usefulness of Turnitin to identify essays written by Artificial Intelligence tools. The methodology used was experimental. The control group was made up of 50 academic essays written by high school students, while the experimental group was made up of 50 essays written by ChatGPT about the same topics. The general similarity indices (IGS), the frequency of works at risk of plagiarism (IGS ≥14%) and the frequency of works with signs of plagiarism by copy-paste detected after manual review were compared. The average IGS was higher in the documents delivered by the students (33% vs. 19% in ChatGPT). The frequency of documents at risk of plagiarism was similar in both groups, but after manual review, only 24% of those created by AI could be detected, compared to 56% of those created by students. These results raise questions about the usefulness of "anti-plagiarism" programs in the face of new digital content generation tools that can lead to ethical and legal dilemmas related to copyright, with AI plagiarism being the topic to be debated.
KEYWORDS: academic plagiarism; cyber plagium; artificial intelligence; anti plagiarism tools; education
Uso de las TIC para el aprendizaje del idioma inglés para estudiantes de secundaria
Authors: Ortiz Rodriguez Hugo Gonzalo , Tejeda Díaz Rafael
Published: April 2023

En el contexto actual se manifiesta la integración de las TIC en el contorno educativo ya que involucra investigar el cómo estas herramientas tecnológicas apoyan a los estudiantes en el proceso de enseñanza-aprendizaje del idioma inglés. En la realización de esta investigación se aplicaron los métodos deductivo, inductivo y estadístico, de tipo analítica y transversal con un enfoque mixto. La encuesta se realizó a 71 estudiantes de Octavo paralelo “A y B” y se utilizó un muestreo probabilístico. El objetivo del presente trabajo determinó que el uso de las TIC favoreció el aprendizaje del inglés aplicando estrategias didácticas que dinamizaron los aprendizajes en los estudiantes de Octavo Grado de la Unidad Educativa Carlos Julio Arosemena Tola, los resultados muestran que los estudiantes están inmersos en el mundo de las tecnologías, pero no precisamente en la utilización de herramientas tecnológicas para el aprendizaje del idioma inglés. Por otro lado, se mostró un bajo grado de conocimiento sobre algunas herramientas tecnológicas para aprender inglés, pero son conscientes de cómo esas herramientas pueden ayudarlos a adquirir las destrezas para el aprendizaje del inglés. Se pudo resaltar de acuerdo a la perspectiva de los educandos indicaron que sí les gustaría que las clases de inglés sean dinámicas aplicando herramientas tecnológicas y es necesario replantear su uso para alcanzar que su aprendizaje sea significativo. Se logró evidenciar que los docentes han utilizado cierto tipo de herramienta tecnológica para el proceso de enseñanza-aprendizaje del inglés, por tal motivo es indispensable capacitarlos para que su uso sea imprescindible para alcanzar los resultados deseados en las destrezas del idioma inglés.
Pancreatitis aguda y las vías óptimas de soporte nutricional
Authors: Navas Ortega Manuel Alejandro , Cercado Cedeño Geovanna Karolina , Pin Veliz Jasmin Estefanía , Bermello Cedeño Dariana Anahi , Pico Ullauri Ariana Celeste , Moreira Loor Cristhian Jesús
Published: April 2023

La pancreatitis aguda es una enfermedad de gran importancia clínica, del manejo inicial del paciente, va a depender la presencia de sus complicaciones o recurrencias de la enfermedad. La clínica incluye dolor abdominal, náuseas y vómitos. El diagnóstico se basa en el soporte nutricional de manera precoz en el paciente y así reducir la morbimortalidad. En el presente artículo, se realizó una revisión bibliográfica con el objetivo de demostrar que actualmente el manejo nutricional en la pancreatitis aguda se basa principalmente en una nutrición temprana, considerando sus beneficios como el mantenimiento de la integridad de la barrera intestinal, la disminución del número de complicaciones infecciosas y sobre todo menos días de hospitalización en estos pacientes. Por ello, se considera de elección la nutrición enteral frente a la parenteral considerando la seguridad y tolerabilidad que se presenta en la primera.  Materiales y Métodos: Se ha realizado una revisión bibliográfica de artículos científicos en diferentes bases de datos, como: Scielo, pubmed, lilacs Google Académico, introduciendo como palabras clave: Manejo de la enfermedad ; pancreatitis aguda; nutrición enteral De igual manera, nos asesoramos en diversas revistas científicas, libros y bibliotecas electrónicas. Discusión: entro del manejo nutricional, en la nutrición oral es más recomendable y factible, utilizar la sonda nasogástrica ante varios factores, entre ellos es la estimulación de la enzima pancreática, en cambio, la sonda nasoyeyunal es recomendable cuando el paciente esté hemodinámicamente estable. Conclusiones. La nutrición enteral (sonda nasogástrica o nasoyeyunal) dependen de la tolerancia del paciente, además, la correcta evolución monitoreo proporcionan el alta hospitalaria.
Salud mental, psicológica y emocional en la pandemia del COVID-19
Authors: Bombón Caizaluisa Marco Fabricio
Published: April 2023

La pandemia del coronavirus o comúnmente llamada COVID- 19, transformó el convivir diario de la sociedad, a nivel mundial; pues a partir de aquello se perdió la normalidad y se estableció una nueva, diferente, extraña e imperecedera realidad. En el ser humano dicha realidad, afectó indiscutiblemente la salud mental, psicológica y emocional, acarreando problemas de estrés, depresión y ansiedad, especialmente en niños, personal de la salud y personas de la tercera edad. Por estas razones, el objetivo de este trabajo fue identificar, en publicaciones científicas, la afectación de la salud mental, psicológica y emocional de los individuos frente a la exposición al virus SARS-CoV-2. Se realizó una búsqueda y análisis de artículos científicos publicados desde el año 2020 hasta el año 2022. Se encontró información y evidencia científica relevante acerca de las consecuencias tanto físicas, mentales y psicológicas que ha dejado la pandemia del Covid-19. También se analizaron estudios realizados en el Ecuador, evidenciándose una importante afectación psicosocial. No obstante, se requiere mayor dominio sobre este tema, para crear estrategias sanitarias oportunas y pertinentes, que mantengan un equilibrio adecuado en la salud física, mental, psicológica y emocional de los seres humanos; procurando superar satisfactoriamente las graves consecuencias de esta enfermedad.
Funcionalidad familiar y variables clínicas en adolescentes
Authors: Polo Martínez Eulalia Maribel , Maxi Maxi Edwin Alberto , Neira Cárdenas Olga Susana
Published: April 2023

La funcionalidad familiar y variables clínicas se encuentra relacionada directamente con el desarrollo de los adolescentes, sin embargo, el sistema educativo ha otorgado poca importancia a su intervención, lo que limita el correcto desarrollo de los adolescentes no solo en su dinámica familiar si no también dentro varios contextos en los que se desarrolla la persona. El objetivo de la presente investigación fue evaluar la funcionalidad familiar y su relación con variables clínicas, mediante un análisis descriptivo, correlacional, transversal de tipo probabilístico, donde se manejó una muestra de 317 adolescentes. El análisis estadístico muestra que el 85.5% son mujeres, el promedio de edad es de 14.31 años, el 74.4% residen en la zona urbana, el 52.4% de los evaluados estudia bachillerato, el 95.9% no posee discapacidad, la religión católica prevalece con el 88.3%. La muestra se encuentra constituida con más prevalencia por familias moderadamente funcionales con 41.3%, cohesión en el nivel alto es el área más prevalente de este constructo con un 68.8%; en variables clínicas prevalece el nivel de anormal con el 42,9% y su área prevalente es síntomas emocionales con el 29.28% de la muestra. Problemas de conducta y afectividad poseen una correlación lineal estadísticamente significativa de -0.174.
Efficacy of Chamomile-Lemon Balm Syrup in Patients With Conventional Drug-Resistant Cardiac Syndrome X: A Single-Arm Clinical Trial
Authors: Noroozi Samaneh , Karimi Mehrdad , Vasheghani Farahani Ali , Omidi Negar , Zargaran Arman , Soleymani Samaneh , Alaeddini Farshid , Rezaeizadeh Hossein
Published: April 2023

Objectives: Treatment of cardiac syndrome X (CSX) remains a major challenge for conventional medicine. In this regard, developing new natural treatments could be an alternative choice. This study was planned to appraise the efficacy of chamomile-lemon balm syrup on chest pain and quality of life in patients with conventional drug-resistant CSX. Materials and Methods: 29 participants with conventional drug-resistant were enrolled in a single-arm clinical trial, and 14 participants completed the study protocol. Chamomile (Matricaria chamomilla L.)-lemon balm (Melissa officinalis L.) syrup was provided for the treatment for the 90-day study period. All conventional treatments of CSX remained unchanged. Efficacy assessment included Seattle Angina Questionnaires (SAQ), 36-item short form survey, and the Hospital Anxiety and Depression Scale (HADS). Results: An improvement was observed in the total score of all questionnaires with statistically significant changes over time of the study (P<0.001). Conclusions: Chamomile-lemon balm syrup showed promising results in improving effect on angina symptoms, quality of life, and anxiety and depression in the patients with drug-resistant CSX. However, a placebo-controlled trial should be performed to verify these data.
The Effect of Supportive Care Environment on the Treatment Process in Hospitals: A Qualitative Study
Authors: Asadi Zahra , Shahcheraghi Azadeh , Zare Leila , Gharehbaglou Minou
Published: April 2023

Objectives: According to the available evidence, changes in the design of medical centers, which can create a more comfortable, pleasant, and natural environment, have reduced the patient tensions and increased their satisfaction with the quality of treatment in the given centers. The present study aimed to investigate the effect of the architecture and design of a supportive care environment on the treatment process in hospitals adopting a qualitative study design. Materials and Methods: This qualitative study with a phenomenological approach was conducted to investigate the effect of an optimal supportive care environment in hospitals based on the experiences and opinions of experts, university professors of architecture, and doctors in hospitals. To this end, experts were interviewed qualitatively and, then, eight main themes as well as 22 sub-themes were classified by performing content analysis. Furthermore, the effect of the environment on the patients, treatment control length, blood pressure control, and subjective nature of the disease’s impact, as well as the effect of social relations on the vital signs, comprehensiveness and acceptability, place of using the supportive care model and a completely mechanical attitude towards humans in the modern period were all evaluated. Results: The effect of the optimal supportive care environment on the patients’ treatment processes was confirmed by qualitatively reviewing the experts’ viewpoints and collecting comprehensive information from other sources. Conclusions: In sum, it was recommended that that the heads of the hospitals should consider the concepts of optimal supportive care environment when designing and/or reconstructing hospitals.
Effect of Crocin and Treadmill Exercise on Spermatogenesis and Testis Structure in Streptozotocin-Induced Diabetic Rats: An Experimental Study
Authors: Hamidi Hassan , Tofighi Asghar , Toluei Azar Javad , Khaki Amir Afshin , Razi Mazdak
Published: April 2023

Objectives: This study aimed to evaluate the effect of crocin and treadmill exercise on oxidative stress, sperm parameters, and testis structure in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In this experimental study, 64 diabetic rats induced by a single intraperitoneal (IP) injection of STZ (50 mg/ kg) were assigned to the following groups (n=8/each): healthy control group, diabetic control group, diabetic group treated daily with crocin at a dose of 50 mg/kg, and one healthy group receiving daily crocin at a dose of 50 mg/kg for 56 days. Some groups such as the controls and diabetics exercised with treadmill, as well as the healthy and diabetic groups performed daily exercise with treadmill and crocin. After crocin treatment, all rats were anesthetized, their blood samples were taken, and the serum level of insulin, glucose, and oxidative stress markers were measured. Finally, the testicles and epididymis were removed and sperm parameters were assessed. Results: Treatment of diabetic rats with crocin along with treadmill exercise significantly replaced the testicular tissue damage, sperm parameters, glucose, and insulin plasma levels (P=0.001). In diabetic rats, moreover, the level of malondialdehyde (MDA) was increased and the levels of superoxide dismutase (SOD) and catalase (CAT) enzymes activity were reduced in the testicular tissue (P=0.001). Crocin administration (50 mg/kg BW) and exercise significantly improved these parameters (P<0.05). Conclusions: Our results confirm the antioxidant role of crocin and the positive role of treadmill exercise in improving the sperm parameters and testicular oxidative damage caused by diabetes.
Descriptive Analysis of Health Screening for COVID-19 at Points of Entry in Pakistan According to the Centers for Disease Control and Prevention Guidelines
Authors: Usman Shamaila , Sattar Afreen , Shahzad Khurram , Baig Zeeshan Iqbal , Khan Mumtaz Ali , Malik Muhammad Wasif , Ansari Jamil , Ashraf Nosheen
Published: April 2023

Introduction: Points of entry (PoE) in Pakistan serve as key conduits for international travel, transport, and trade. Central Health Establishment (CHE) is a key stakeholder in the implementation of the International Health Regulations 2005 (IHR) core capacities at PoE and National Action Plan 2020 against COVID-19. A comprehensive screening plan for COVID-19 was carried out effectively despite limitations. Methods: A descriptive study on CDC guidelines for health screening at PoE was conducted from February 2020 to March 2021. Guidelines are based on 11 attributes to be implemented; these include legal and regulatory bodies to detain the travelers as suspect, isolate, and coordinate at PoEs, funds for screening, well-equipped quarantine facilities, referral health care facilities, protocols for primary and secondary screening, capacity building, supply of personal protective equipment and screening tools, and provision of basic facilities at isolation areas. Data were collected using both qualitative and quantitative methods from health officers and quarantine assistants of PoEs. The analysis of CHE’s information system was performed to assess the management of traveler surveillance. Results: Eleven attributes were addressed for health screening according to CDC guidelines and well implemented at PoE by CHE under the flagship of the MNHR&C. Primary health screening of 4,088,119 inbound travelers was conducted. Secondary health screening led to the referral of performed at airports for inbound travelers, with a positivity rate of 0.32. Conclusion: Preparedness and response for COVID-19 at PoE are in line with the National Action Plan of the Government of Pakistan and IHR (2005).
Ethnic Variation in the Association Between Objective and Subjective Health in Older Adults
Authors: Assari Shervin , Najand Babak , Bazargan Mohsen
Published: April 2023

Introduction: The African Americans’ health paradox can be defined as better subjective health held of African American individuals compared to White individuals, despite their higher objective and medical adversities such as chronic medical conditions (CMCs). This phenomenon depicts African Americans’ relative resilience (advantage). However, most of the existing literature on this topic is limited to studies comparing African Americans and Whites. There is little research, if any, on this phenomenon among other ethnic groups. To fill this gap in the literature, this study tests the African Americans’ health paradox with consideration of Latinos as the control group. Methods: This cross-sectional study collected demographic data, socioeconomic status, CMCs, and subjective health of 734 African American and Latino older adults residing in south Los Angeles. Logistic regression was used for data analysis. Results: 118 Latino and 616 African Americans entered our study. Overall, a higher number of CMCs was associated with lower subjective health, however, a statistically significant interaction between ethnicity and the number of CMCs suggested that this association is weaker for African Americans than Latinos, which is the African American health paradox. Conclusion: African Americans with a higher number of CMCs report better subjective health compared to Latinos with the same number of CMCs. This finding is indicative of a relative advantage of African Americans compared to other ethnic groups.
SISTEMA IOT INDUSTRIAL PARA MONITORAMENTO DE VIBRAÇÕES DE MÁQUINAS ROTATIVAS
Authors: FONTENELE JHONE
Published: April 2023

Industrial IoT systems have been used to collect and analyze data from industrial processes. In this paper, we describe the development of a system containing IoT technologies to perform vibration monitoring of rotating machines for use in predictive maintenance systems. A two-axis vibration attached to a motor is used to generate the signal which is sent to a programmable logic controller using Modbus RTU protocol. Measurement history is stored in a MySQL relational database and presented through a dashboard using Grafana. Connection between controller and database is done by means a flow developed in Node-RED using OPC-UA protocol. Initial analysis were carried out using ranges of values in accordance with technical standards to establish tolerable levels of vibration. The system was successfully deployed and tested in a workbench; the methodology and results are reported in this paper.
Néptánc, mint mozgásforma az óvodás korú gyermekek és szüleik életében
Authors: Mező Boglárka , Bak Gabriella , Laoues-Czimbalmos Nóra
Published: April 2023

A néptánc, mint mozgásforma fejleszti a kooperációs készségeket, az összetartozás érzését, mindemellett kiváló közösségteremtő hatással is bír. A gyermekek fogé- konyabbak az újdonságokra, ha közösségben tanulhatnak együtt, mint például egy táncos foglalkozás keretein belül. A roma társadalom összetartó ereje segítheti ebben a gyer- mekeket. A kutatásunk célja annak tisztázása, hogy: bizonyos ráhatással van-e a mozgás és a tánc a gyermekekre és szüleikre további életvitelük tekintetében? Az infokommu- nikációs eszközök használata milyen mértékben van jelen manapság az óvodások és szüleik életében? Továbbá: milyen lehetőségeik vannak táncolásra, valamint pozitív hatással volt-e a gyermekek szervezetére, életére, szociális és érzelmi képességeik fejlődésére, ha időben, óvodáskorban elkezdték elsajátítani ezeket a mozgásformákat, népi motívumokat? Összehasonlítottunk a roma és nem roma származású személyeket, akiknek valamilyen formában már van tapasztalatuk a tánccal, mint mozgáskultúrával és akiknek semmilyen előzetes élményük, tapasztalatuk nincs ezzel kapcsolatban.
A territorialidade simbólica da Igreja Universal do Reino de Deus a partir do cinema brasileiro
Authors: SANTOS FILHO CHRISTOVAM REIS DOS
Published: April 2023

A religião é um dos campos de interesse da geografia e as estratégias religiosas usadas pelas instituições religiosas se modificam conforme as demandas sociais existentes. Esse texto se trata de investigar uma ação territorial religiosa adotada pela Igreja Universal do Reino de Deus (IURD) a partir dos últimos sucessos de bilheteria no cinema nacional, produzidos pela Rede Record de Televisão, buscando compreender o desenvolvimento territorial dessa instituição a partir de sua territorialidade em produções cinematográficas. Para isso, associamos o conceito geográfico de apropriação simbólica para o sagrado a fim de aproximar tais conceitos com a tática de marketing da IURD. Os procedimentos metodológicos utilizados foi uma observação de campo, acompanhando os sujeitos em uma jornada de ida aos cultos da IURD e ao cinema para assistir as produções cinematográficas promovidas pela instituição. Assim, consideramos que a IURD utiliza uma estratégia territorial midiática de apropriação simbólica por meio do cinema para atrair novos adeptos ao seu conjunto de crenças e fidelização ao discurso de seus líderes simbolicamente defendidos nos enredos dos filmes.Palavras-chave: Territorialidade do sagrado; Estratégia de marketing pelo cinema; Apropriação simbólica.