bluuebunny/crossref_metadata_2025 huggingface dataset:
Chalcone Dimerisation and a Mass Spectral Conflict
Authors: Harrison William T. A. , Musgrave Oliver C. , Miller Marina M.
Published: December 2009

The reaction of a trimethoxychalcone with acetic anhydride and sulfuric acid gives a deep red triarylindenopyrylium cation (as its hydrogen sulfate salt) the structure of which is established by X-ray crystallography and 1H NMR spectroscopy.
Synthesis and Spectroscopic Characterisation of a New Class of Heterobimetallic Homoleptic Diethanolaminate Complexes of Niobium(V) and Tantalum(V)
Authors: Ghadwal Rajendra Singh , Singh Anirudh
Published: December 2009

Nine heterobimetallic homoleptic diethanolaminate complexes of the types: [Nb(Rdea)3{Ta(Rdea)2}] (where Rdea = RN(CH2CH2O-)2 and R = H, 2; Me, 3; Bu n, 4; Ph, 5), [Nb(Rdea)3{Al(Rdea)}] (R = H, 6; Me, 7; Bu n, 8; Ph, 9), and [Nb(Phdea)3{Sb(Phdea)}] 10 have been prepared for the first time by the equimolar reactions of [Nb(Rdea)2(RdeaH)] with [Ta(Rdea)2(OPr i)] or [Al(Rdea)(OPr i)] or [Sb(Phdea)(OPr i)] in benzene. The structural features of the new complexes have been elucidated by IR and NMR (1H, 27Al) spectroscopies.
Oxidation of Aspirin by a New Oxidant Diperiodatoargentate(III) in Aqueous Alkaline Medium
Authors: Kiran T.S. , Nandibewoor S.T.
Published: December 2009

The kinetics of oxidation of aspirin by diperiodatoargentate(III) (DPA) in alkaline medium at a constant ionic strength of 1.0 mol dm−3 has been studied spectrophotometrically. The reaction between DPA and aspirin in alkaline medium exhibits 1: 2 stoichiometry (aspirin: DPA). The reaction is of first order in [DPA] and has less than unit order in both [ASP] and [alkali]. However, the order in [ASP] and [alkali] changes from first order to zero order as the concentration changes from lower to higher concentration. A decrease in the dielectric constant of the medium increases the rate of the reaction. The effect of added products and ionic strength of the reaction medium have been investigated and a mechanism is proposed.
Oxidation Products from 4-Methoxy-2-Methyl-1-Naphthol
Authors: Musgrave Oliver C. , Skoyles Douglas
Published: December 2009

The oxidation of 4-methoxy-2-methyl-1-naphthol by lead(IV) oxide gives 1-hydroxy-4-methoxy-2-naphthaldehyde, 4-methoxy-1,2-naphthaquinone and a spironaphthalenenaphthopyranone. The last of these undergoes aerial oxidation in solution forming a dinaphtho-oxepinquinone.
Kinetics of Oxidation of 1,4-Butylene Glycol by Dihydroxydiperiodatoargentate(III) in Alkaline Medium
Authors: Shan Jin-Huan , Li Sheng-Min , Huo Shu-Ying , Zhao Wen-Jie , Shen Shi-Gang , Sun Han-Wen
Published: December 2009

Kinetics of oxidation of 1,4-butylene glycol by dihydroxydiperiodatoargentate(III) in alkaline liquid has been investigated by spectrophotometry in the 298.2–318.2K range. The order in oxidant was pseudo first order and the order with respect to 1,4-butylene glycol was 1< nap<2. The associated rate law was: –d[Ag(III)]t/dt = { kK1 K2[OH-][HOCH2CH2CH2CH2OH]2[Ag(III)]t}/{[H2IO43-] + K1[OH-] + K1 K2[OH-][HOCH2CH2CH2CH2OH]} = kobs [Ag(III)]t. A plausible mechanism involving a pre-equilibrium of adduct formation between the complex and reductant was proposed. The activation parameters along with rate constants of the rate-determining step were calculated.
Synthesis of Novel Salicylaldimine Schiff Bases with a Pendant Benzo-10-Aza-15-Crown
Authors: Li Jianzhang , Yan Jie , Wei Xingyao , Zhou Bo , Qin Sheng-Ying
Published: December 2009

Novel salicylaldimine mono-Schiff bases with aza-crown pendant have been synthesised via condensation of 3-[(benzo-10-aza-15-crown-5)methyl] salicylaldehyde with substituted aniline and characterised by 1H NMR, IR, mass spectroscopy and elemental analysis. The crystal structure of N-(4-hydroxy-3- formylbenzyl)benzo-10-aza-15-crown-5 aldimine with 4-aminophenol (HL10) has been determined from X-ray diffraction data.
Novel Stereoselective Synthesis of (Z)-2-Arylthio-Substituted 1,3-Enynes from (E)-α-Stannylvinyl Sulfides and 1-Alkynes
Authors: Cai Ming-Zhong , Wang Dong , Wang Ping-Ping
Published: December 2009

( E)-α-Stannylvinyl sulfides 1 underwent the iododestannylation reaction with iodine to give the ( E)-α-iodovinyl sulfides 2, which were coupled directly with terminal alkynes 3 without isolation in the presence of Pd(PPh3)4 and CuI co-catalyst to afford stereoselectively ( Z)-2-arylthio-substituted 1,3-enynes 4 in good yields.
Protic Acidic Ionic Liquids Promoted Formation of 1,5-Benzodiazepines: Remarkable Effects of Cations and Anions on their Performances
Authors: Du Yuying , Tian Fuli
Published: December 2009

A series of protic acidic ionic liquids have been used as solvents and catalysts for the synthesis of 1,5-benzodiazepines. Success of the condensation appears to lie in the choice of cation–anion combinations and the ionic liquid [HBIm]CF3SO3 was found to be the best. Acidities of five protic acidic ionic liquids have also been investigated using Hammett method in 1,2-dichloromethane solutions. The ionic liquid [HBIm]CF3SO3 can be recovered conveniently and reused for five times without remarkable loss of activity.
Epoxidation of Alkenes by Hydrogen Peroxide over 12-Heteropolyacids of Molybdenum and Tungsten (H3PMo3W9O40) Combined with Cetylpyridinium Bromide
Authors: Ding Yong , Ma Baochun , Gao Qiang , Suo Jishuan
Published: December 2009

In the epoxidation of 4-vinylcyclohex-1-ene with H2O2 in monophasic acetonitrile solution catalysed by Keggin-type 12-heteropolyacids, i.e., H3PMo12- nW nO40 ( n = 0–12), which are precursors of active peroxo complexes, and phase transfer catalysts Q+Br–, the catalyst H3PMo3W9O40 showed the highest activity, giving a conversion of 98% and a selectivity of 88%. By this method, a variety of water-insoluble unactivated alkenes, internal or terminal, open chain or cyclic and isolated, were epoxidised under mild conditions and after relatively short reaction times. The state of the H3PMo3W9O40/CPB/H2O2/CH3CN system was studied using UV, IR, and 31P NMR spectroscopies with the [H2O2]: [HPA] ratio = 50. Several peroxo species were observed by 31P NMR spectroscopy at a lower field than the original heteropolyacids. Their composition varied regularly with that of the starting catalyst. The P-containing peroxo species formed were deduced as [(PO4){Mo4– xW xO20}]3- ( x = 0-4), which are the true catalytically active species under the reaction conditions.
Bis (Salicylaldehyde-1, 2-Phenylene Diimine)Mn(III) Chloride (Mn(III)-Salophen) Catalysed Oxidation of Thiols to Symmetrical Disulfides Using Urea Hydrogen Peroxide (UHP) as Mild and Efficient Oxidant
Authors: Karami Bahador , Montazerozohori Morteza , Habibi Mohammad Hossein
Published: December 2009

A variety of thiols were oxidised efficiently by a catalytic amount of Mn(III)-salophen 1 in the presence of urea hydrogen peroxide adduct 2 as a convenient and mild oxidant to afford the corresponding disulfides in high yields in quite short reaction times.
Microwave-Assisted Synthesis of 2-Phenoxybenzoic Acids
Authors: Pellón Rolando F. , Martín Ana , Mesa Miriam , Docampo Maite L. , Gómez Victoria
Published: December 2009

Substituted 2-phenoxybenzoic acid derivatives were synthesised in high yield and in short reaction times using the Ullmann condensation of 2-chlorobenzoic acid with phenol derivatives under microwave irradiation in dry media.
Direct Introduction of Bromine onto the Bridged Methylene of 5,13-di-tert-butyl-8,16-dimethyl[2.2]metacyclophane
Authors: Yamato Takehiko , Miyamoto Shinpei , Okabe Ryo , Tazaki Yoshinori , Anai Hideyuki
Published: December 2009

Treatment of 5,13-di- tert-butyl-8,16-dimethyl[2.2]metacyclophane 1 with 1,3-dibromo-5,5-dimethylhydantoin (DBMH) in CH2Cl2 led to the first successful introduction of bromine onto the bridged methylene group.
New Tetrahydro-1,2,4,5-Tetrazinan-3-Ones and Oxoverdazyl Free Radicals
Authors: Plater M. John , Sinclair James P. , Kemp Steven , Gelbrich Thomas , Hursthouse Michael B. , Gómez-García Carlos J.
Published: December 2009

A series of tetrahydro-1,2,4,5-tetrazinan-3-ones have been prepared by the reaction of carbonic acid bis (1-methylhydrazide) with aromatic aldehydes. These were oxidised to oxoverdazyl free radicals and used immediately for ESR spectroscopy studies that indicate that the unpaired electron is delocalised over the verdazyl ring. The ESR spectra can be very well simulated considering hyperfine couplings with the four nitrogen atoms of the verdazyl ring and the six hydrogen atoms of the two methyl groups bonded to it.
Catalytic Transfer Hydrogenation of Imines to Secondary Amines Using Inexpensive Commercial Zinc Dust and Ammonium Formate
Authors: Abiraj K. , Dinesh B. , Srinivasa G.R. , Gowda D. Channe
Published: December 2009

A simple protocol for the chemo-selective reduction of imines to the corresponding secondary amines in good yield using inexpensive commercial zinc dust and ammonium formate in methanol at ambient temperature and pressure is described.
One-pot Preparation of Caffeic Acid Esters from 3, 4-Dihydroxybenzaldehyde
Authors: Hu Wei-Xiao , Xia Chun-Nian , Wang Guo-Hong , Zhou Wei
Published: December 2009

A convenient one-pot process for preparing various esters of caffeic acid from 3,4-dihydroxybenzaldehyde has been developed. The alcohols or phenols react with Meldrum's acid to form malonic acid mono-esters, which, without separating, immediately react with 3,4-dihydroxybenzaldehyde to afford the desired esters in good yield. The 1H NMR data and X-ray diffraction analyses indicate that these α,β-unsaturated esters are in trans ( E) form in accord with natural esters.
Medium-size Cyclophanes, 71. Synthesis, Structures and Photo-Induced Cyclisation of 1,2-Diphenyl[2.n]Metacyclophan-1-Enes
Authors: Yamato Takehiko , Saisyo Tatsunori , Hironaka Tohru , Miyamoto Shinpei
Published: December 2009

McMurry cyclisation of 1, n-bis(5-benzoyl-2-methoxyphenyl)alkanes 2 afforded 1,2-diphenyl[2. n]metacyclophan-1-enes 3, which were converted into the corresponding [ n](4,5)phenanthrenophanes 5 by photo-induced cyclisation in the presence of iodine as an oxidant.
Acylation of Ambident Vinylogous Urethanes Exocyclic to Thiazolidines and Reduced Thiazines
Authors: Avent Anthony G. , Loakes David , Young Douglas W.
Published: December 2009

The vinylogous thiazine urethanes 1 are invariably acylated on carbon and not on nitrogen, even when the carbon is “blocked” as in 18. The analogous thiazolidine 2 is acylated either on carbon or nitrogen, depending on the electrophile used.
A Convenient Procedure for the Iodination of Arenes
Authors: Sathiyapriya R. , Karunakaran R. Joel
Published: December 2009

Two different procedures for the iodination of various arenes using potassium bromate and potassium iodide in the presence of hydrochloric acid are presented. Iodination of benzene, naphthalene and deactivated arenes were carried out in aqueous acetic acid medium and good yields of iodoarenes were obtained. Activated arenes, such as anisole, substituted phenols and anilines underwent excellent conversion to their iodinated products in an aqueous methanol medium.
An Unprecedented Study of the Rearrangement of 5,5-Diazidobarbituric Acids under Various Conditions
Authors: Khattab Ahmed F. , Kappe Thomas
Published: December 2009

The unexpected parabanic acid derivatives 6a,b were obtained via unprecedented rearrangement of 5,5-diazidobarbituric acids 2a,b upon stirring in water at 50-60°C. Themolysis of diazides 2a,b in benzyl alcohol at 120–130°C afforded the tetrazole derivative 11 and/or benzyl allophanate 14.
The Preparation of Novel Ligustrazine Derivatives as Potential Cerebrocardiac Vascular Agents
Authors: Cheng Xian-chao , Liu Xin-yong , Xu Wen-fang
Published: December 2009

A series of novel substituted cinnamoylpiperazinyl ligustrazine derivatives 7 has been prepared by alkylation of cinnamoylpiperazines by (chloromethyl)trimethylpyrazine (5) or by cinnamoylation of trimethyl(piperazinomethyl) pyrazine (6).
Synthesis of Enynones from Alkynes, Alkynyl Ketones and Aromatic Aldehydes Using the TiCl4/Et3N Reagent System
Authors: Periasamy Mariappan , Karunakar Galla V. , Bharathi Pandi
Published: December 2009

Alkynyltitanium species, prepared in situ from alk-1-ynes using the TiCl4/Et3N reagent system, react with aromatic aldehydes to give enynones 2 in 49–38% yields. Reaction of alkynyl aryl ketones with aromatic aldehydes and the TiCl4/Et3N reagent gives the enynones 2 in 78–92% yields.
Synthesis and X-ray crystal structure analysis of 4-(3,4-dichlorophenyl)-2-(3,4,5-trimethoxy-benzylidene)-3,4-dihydro-naphthalen-1(2H)-one: Sertraline key intermediate analog
Authors: Kavitha Chandagirikoppal V. , Mantelingu Kempegowda , Sarala Gangadaraiah , Naveen S. , Anandalwar Sridhar M. , Prasad Javaregowda Shashidhara , Rangappa Kanchugarakoppal S.
Published: December 2009

The novel bioactive compound 4-(3,4-dichlorophenyl)-2-(3,4,5-trimethoxy-benzylidene)-3,4-dihydro-naphthalen-1(2 H)-one was synthesised in three different methods, namely, conventional, MW irradiation with solvent and MW irradiation without solvent. The synthesised compound was characterised by spectroscopic techniques and finally confirmed by X-ray crystal structure analysis.
Synthesis of substituted 7,7-dialkyl-5-chromanones and related compounds, new potassium channel activator
Authors: El-Telbani Emad M.
Published: December 2009

We describe the synthesis of 1-(6-hydroxy-4-methoxy-7,7-dimethyl-6,7-dihydro-5H-furo[3,2-g]chromen-5-yl) pyrrolidin-2-one (7) analogue to Cromakalim. Moreover, the synthesised furochromanone used to synthesise a fused heterocyclic compounds containing thiophene and coumarin rings via Gewald and Wittig reactions; respectively.
Synthesis and spectroscopic studies of some heterobinuclear derivatives of bismuth(III)
Authors: Sharma Pankaj Kumar , Singh Yashpal
Published: December 2009

The reactions of chlorobis(dialkyldithiophosphato)bismuth(III), [{(RO)2P(S)S}2BiCl] with sodium tetraisopropoxoborate(III), NaB(OPri)4 in 1: 1 molar ratio in refluxing benzene solution yield the corresponding heterobinuclear derivatives of the type [{(RO)2P(S)S}2Bi(μ-OPri)2B(OPri)2] [where R = Me(1); Et(2); Pri(3); Prn(4); and Bun(5)]. All these derivatives are moisture sensitive, dark-brown, viscous liquids that are soluble in common organic solvents and have been characterised by elemental analyses and molecular weight measurements. Probable structures for 1–5 have been proposed on the basis of spectroscopic studies.
Synthesis of mono-substituted p-tert-butylcalix[7]arenes with reactive substituents
Authors: Luo Zhiyang , Gong Shuling , Zhang Chunlei , Zheng Qin , Chen Yuanyin
Published: December 2009

Three mono-substituted p-tert-butylcalix[7]arenes with various reactive substituents have been synthesised by treating p-tert-butylcalix[7]arene with doubly functional electrophiles. Two amino derivatives, 43-acetohydrazideoxy- p-tert-butylcalix[7]arene and 43- N-(2-aminoethyl)acetamideoxy- p-tert-butylcalix[7]arene were obtained by aminolysis of 43-ethoxycarbonylmethoxy- p-tert-butylcalix[7]arene with hydrazine hydrate or ethylene diamine in good yield.
Synthesis of a New Chiral Auxiliary: Non-Cross-Linked Polystyrene Bound (4S)-Oxazolidine-2-Thione
Authors: Chen Jianian , Nie Junqi , Huang Yanling , Chen Zuxing , Yang Guichun
Published: December 2009

A new chiral auxiliary, non-cross-linked polystyrene bound (4 S)-oxazolidine-2-thione, was synthesised from L-tyrosine in 24.2% by a seven step method.
Intermolecular silyl migration reactions
Authors: Rodríguez Carolina , García Antonio G. , Marco-Contelles José
Published: December 2009

Sodium hydride promoted O-alkylation of 2-[(4- t-butyldimethylsilyloxy)phenyl]ethan-1-ol with 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene depend on the solvent used in the coupling reaction. Mixtures of 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1- t-butyldimethylsilyloxyethane and 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl] ethan-1-ol (in DMF), or 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1- t-butyldimethylsilyloxyethane and 4-[2-(2-bromo-4,5-dimethoxybenzyloxy)ethyl]phenol (in THF), were detected. These results can be explained by an unusual intermolecular silyl migration reaction.
Unexpected cleavage and formation of C–C bonds by the nitration of 2,2′-biindanyl-1,1′,3,3′-tetraone
Authors: Ji Qi , Cheng Kai-Ge , Li Yan-Xia , Pang Mei-Li , Han Jie , Ma Yu-Xin , Meng Ji-Ben
Published: December 2009

A novel compound, triindanylhexaone, is formed unexpectedly as a major product from the nitration of 2,2′-biindanyl-1,1′,3,3′-tetraone. The structure was clearly established by X-ray crystallography. The reaction mechanism is interpreted as involving an oxidation-induced radical addition.
Efficient synthesis of dihydrazide crown ethers by fast addition method
Authors: Eshghi Hossein , Bakavoli Mehdi , Hosseini Mosayyeb
Published: December 2009

The novel macrocyclic dihydrazides which structurally related to luminal were synthesised. These compounds were obtained in the macrocyclisation step by fast addition method and the results were compared with solvent-free conditions.
The synthesis of phenolic propane-1, 2- and 1, 3-diols as intermediates in immobilised chelatants for the borate anion1
Authors: Tyman John H.P. , Payne P.B.
Published: December 2009

The isomeric 3-(hydroxyphenyl)propane-1, 2-diols have been synthesised from allylic precursors by epoxidation and cleavage. Several different methods have been examined for obtaining 1-(methoxyphenyl)propane-1, 3-diols. 2-(methoxyphenyl)propane-1, 3-diols and certain hydroxy analogues have been obtained from benzaldoximes converted by oxidation to methoxy- and benzyloxynitromethylbenzenes followed by hydroxymethylation with formaldehyde and catalytic hydrogenation.
Hyosmin, a New Lignan from Hyoscyamus Niger L
Authors: Begum Ahil Sajeli , Verma Shweta , Sahai Mahendra , Asai Teigo , Hara Noriyuki , Fujimoto Yoshinori
Published: December 2009

Hyosmin (1) a new lignan has been isolated from the seeds of Hyoscyamus niger L. (Solanaceae), and its structure shown to be the 3-{[(2 R)-2-carbomethoxy-2-hydroxy]ethyl}benzoate ester of {(2 R,3 S,4 S)-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-4-[(4-hydroxy-3-methoxyphenyl)methyl]tetrahydrofuran
Synthesis, Structure and Reactivity of New Solvent (MeOH or Me2SO) Coordinated Rh(III) Complexes: A Cyclic Series of Chemical Transformations Involving RhCl3-mediated azo Cleavage
Authors: Pratihar Jahar Lal , Pattanayak Poulami , Chattopadhyay Surajit
Published: December 2009

Reaction of RhCl3.3H2O with 2-(phenylazo) aniline, HL–NH2, in boiling methanol afforded three products [RhCl2 (L–NH2)(HL–NH2)], 1, [RhCl2(L–NH2)(H2NPh)] 2, and [RhCl2(L–NH2)(MeOH)], 3. The sequential transformation of 1 to 2 followed by 3 has been established where the –N=N– cleavage occurs during the conversion of 1 to 2. Further, treatment of 3 with HL–NH2 in dichloromethane furnished 1 to complete a reaction cycle.
CeCl3·7H2O–NaI/SiO2 promoted Beckmann rearrangement (under solvent-free and microwave irradiation)
Authors: Li Zheng , Lu Zhong , Ding Runbo , Yang Jingya
Published: December 2009

CeCl3·7H2O–NaI/SiO2 system promoted Beckmann rearrangement of a variety of aldoximes and ketoximes was efficiently conducted under solvent-free and microwave irradiation conditions. This protocol afforded an alternative method for the preparation of amides by Beckmann rearrangement with advantages of short reaction time, high yield, no pollution, simple operation and easy work-up.
Mechanism of hydrolysis of substituted N-thiazolylcarbamate esters in OH- solutions
Authors: Araújo M. Eduarda M. , Norberto Fátima , Pamplona Teresa , Iley Jim
Published: December 2009

Substituted secondary N-thiazolylcarbamate esters and some tertiary N-methyl, N-thiazolyl carbamate esters have been synthesised and the mechanism of the OH- catalysed hydrolyses investigated. These proved to be E1cB and BAc2 respectively, and this behaviour was compared with that of other carbamates.
PCC/SiO2–H2SO4: A Convenient System for in situ Oxidative β–acetamidoketone Formation from Aromatic Alcohols and Silyl Ethers
Authors: Khodaei Mohammad Mehdi , Khosropour Ahmad Reza , Fattahpour Pyman
Published: December 2009

A convenient and efficient one-pot multicomponent synthesis of β-acetamidoketones from aromatic alcohols and silyl ethers in the presence of acetylchloride and a combination of PCC and silica gel supported sulfuric acid is described.
Cooperativity effect of mercaptosuccinic acid on the oxidation of thiourea by methylene blue in acidic medium
Authors: Mishra K.K. , Sylvester Jane
Published: December 2009

The principal substrate, thiourea (TU) interacts with methylene blue (MB) in a molar ratio of 2: 1 and the rate of oxidation is considerably enhanced in presence of mercaptosuccinic acid (TMA). The order of reaction is zero in MB and unity with respect to TU. The rate initially increases on increasing [TMA] but it is not affected at higher concentrations of TMA ( ca ≥ 2.0 × 10−4 M). The order in MB changes from zero to –½ at lower concentrations of MB ( ca ≤ 1.0 × 10−5 M). The reaction is characterised by a high negative entropy of activation. The kinetic features have been explained in terms of a competitive reaction between the half-reduced MB radical (HM·) and the TU molecule. This postulate has been verified by making the runs in presence of EDTA. The possibility of the participation of metal ion(s) as an impurity was ruled out on the grounds that the reactions of TU and TMA with MB individually in acidic medium do not show a negative order.
Medium-size cyclophanes, 741 Synthesis of novel helically twisted anti-1,2-areno[2.n]metacyclophanes
Authors: Saisyo Tatsunori , Hironaka Tohru , Shiino Mikiko , Yamato Takehiko
Published: December 2009

An anti-8,17-dimethoxy[2.3]metacyclophan-1,2-dione was converted to the corresponding helically twisted 1,2-naphtho[2.3]metacyclophane by the condensation with 1,2-phenylenediacetonitrile.
A convenient synthesis of 2-formyl-1,4,5,8-tetramethoxynaphthalene
Authors: Xu De-Feng , Guan Peng-Jian , Li Shao-Shun
Published: December 2009

A convenient and concise synthesis of 1,4,5,8-tetramethoxynaphthalene can be achieved by methylation of 2,3-dihydronaphthazarin with dimethylsulfate in the presence of phase transfer catalytic in 90.3% yield, then formylation of 1,4,5,8-tetramethoxynaphthalene can afford 2-formyl-1,4,5,8-tetramethoxynaphthalene in 96.2% yield.
Synthesis and biological activity of new 1-[4-(substituted)-piperazin-1-ylmethyl]-1H-benzotriazole
Authors: He Feng-qi , Liu Xing-hai , Wang Bao-lei , Li Zheng-Ming
Published: December 2009

A new kind of benzotriazole derivatives has been designed and synthesised. The structures of all of the title compounds were characterised by 1H NMR, IR, MS and elemental analyses. Herbicidal activities of the benzotrizole derivatives were evaluated with barnyard grass and rape cup and KARI tests. The results showed that compounds exhibited weak herbicidal activities against barnyardgrass and rape and KARI enzyme.
H2O2/HCl as a new and efficient system for synthesis of 2-substituted benzimidazoles
Authors: Bahrami Kiumars , Khodaei Mohammad M. , Kavianinia Iman
Published: December 2009

The system, H2O2/HCl, oxidises carbon–nitrogen bonds for the synthesis of benzimidazoles from aldehydes and diamines in water at 100°C. Both aryl aldehydes bearing electron-donating and electron-withdrawing substituents afforded desired benzimidazoles in excellent yields. This procedure is also applicable to substituted o-phenylenediamines, which produced 2-phenylbenzimidazoles smoothly in excellent yields. The simplicity of the system, the use of water as the solvent, large-scale synthesis and easy work-up are main advantages of this procedure.
A New Thiophene-Based Tripodal Ligand: Synthesis and Cation Binding Properties
Authors: Attayibat Ahmed , Radi Smaail , Lekchiri Yahya , Ramdani Abdelkrim , Hacht Brahim , Morcellet Michel , Bacquet Maryse , Willai Stéphanie
Published: December 2009

The synthesis of a new tripodal ligand based on a thiophene ring is reported. The complexation properties of this compound towards bivalent metal ions (Hg2+, Cd2+, Pb2+, Cu2+, Zn2+) and alkaline metal ions (Li+, Na+, K+) has been studied by a liquid–liquid extraction process and the extracted cation percentage was determined by atomic absorption measurements.
Complexes of zinc(II) with 1,2-disubstituted benzimidazoles
Authors: Krishnamurthy Ganganaika , Shashikala Narasimhaiah
Published: December 2009

The reactions of hydrated halides and perchlorate of divalent zinc with 1- o-hydroxybenzyl-2- o-hydroxyphenylbenzimidazole (L1), 1- m-hydroxybenzyl-2- m-hydroxyphenylbenzimidazole (L2),1- p-hydroxybenzyl-2- p-hydroxyphenylbenzimidazole (L3) and 1- o-chlorobenzyl-2- o-chlorophenylbenzimidazole (L4) ligands in 1:2 and 1:3 molar ratios in absolute ethanol/acetone at refluxing temperature produced white/pale yellow complexes of the formula ZnX2L n. yH2O [L = L1, X = Cl, n = 2, y = 1; X = Br, n = 2, y = 0; X = I, n = 3, y = 1; X = ClO4, n = 2, y = 0; L = L2, X = Cl, Br, n = 2, y = 1, X = ClO4, n = 2, y = 2; L = L3, X = Cl, n = 2, y = 0; X = Br, I, n = 3, y = 2; X = ClO4, n = 2, y = 1; L = L4, X = Cl, n = 3, y = 2; X = Br, n = 3, y = 5; X = ClO4, n = 2, y = 0]. The complexes are characterised by elemental analysis, conductivity, thermal analysis, IR, 1H and 13C NMR spectral studies.
Peroxo-tungsten complex catalysed synthesis of adipic acid and benzoic acid with hydrogen peroxide
Authors: Zhu Wenshuai , Li Huaming , He Xiaoying , Shu Huoming , Yan Yongsheng
Published: December 2009

A new peroxo tungsten complex including N,N bidentate ligand was prepared and characterised, which catalysed H2O2 synthesis of adipic acid and benzoic acid in good yields without organic solvent and phase-transfer catalyst. The reaction is safe, clean and operational in the absence of acidic additives.
Microwave Assisted Synthesis of Some Novel Thiadiazolothienopyrimidines
Authors: Prasad M. Raghu , Raziya S. , Kishore D. Pran
Published: December 2009

3-Amino-2-mercapto-3,5,6,7,8,9-hexahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one (4) was prepared, and from this a series of 2-(arylaminomethyl)-7,8,9,10-tetrahydro-6H,11H-cyclohepta[4,5]thieno[2,3-d][1,3,4]thiadiazolo [3,2-a]pyrimidin-11-ones (6a–d) were synthesised through the corresponding 2-chloromethyl compound (5) with aromatic amines under microwave irradiation.
Stereospecific Synthesis of Bisdihydroxylated Dicyclopentadiene
Authors: Salamci Emine , Sahin Ertan
Published: December 2009

The first bisdihydroxylation of dicyclopentadiene (3) with OsO4–NMO gave the exo-tetrol 4a as a sole product in one step. The stereoselectivity in bisdihydroxylation of 3 has been determined by an X-ray diffraction analysis of the compound 4a and tetraacetate 4b.
A Novel Isoflavone from Urophylluma Chinensis
Authors: Guo Hui , Cai Xiaohua , Qian Junqing
Published: December 2009

A novel isoflavone, urophyllumol (1), and seven known compounds, were isolated from the ethanolic extract of the leaves and twigs of Urophylluma chinensis Merret Chun. Their structures were determined by analysis of spectral data or comparing them with authentic samples.
Superacid-catalysed Arylation and Rearrangement in 2-Hydroxy-2,2′-Biindan-1,1′,3,3′-tetrone and Facile Synthesis of 4-Substituted Phthalazinones
Authors: Das Suven , Fröhlich Roland , Pramanik Animesh
Published: December 2009

2-Hydroxy-2,2′-biindan-1,1′,3,3′-tetrone 1 upon stirring with moderately activated and deactivated arenes in superacidic triflic acid (CF3SO3H, TfOH) medium produces arylated adducts 2-aryl-2,2′-biindan-1,1′,3,3′-tetrones 3 within 1-2 h. Prolonged stirring (12–24 h) of the same reaction mixture gives rearranged products 3-(aryl-1,3-indanedionylmethylene)isobenzofuranones 4 involving three types of regioselectivity. The arylated adducts 3 and rearranged products 4 undergo nucleophilic ring opening and condensation with hydrazine hydrate to produce 4-substituted mono- and diphthalazinones depending upon the reaction temperature.
The Synthesis of a New Fused Heterocyclic System: Hexahydro[1,5]Oxathiocino[2,3-b]Pyrazine
Authors: Zaleska Barbara , Karelus Marcin , Serda Paweł
Published: December 2009

A brief synthesis of the new heterocyclic system of 1,2,3,7,8,10a-hexahydro-6 H,10 H-[1,5]oxathiocino[2,3- b]pyrazin-10-imine was achieved, starting from piperazin-2-one derivatives and 1,3-dibromopropane.
Synthesis of Novel Thieno[2,3-b][1,6]Naphthyridine and Thieno [2′,3′: 2,3]pyrido[4,5-d]Pyrimidine Derivatives
Authors: Al-Omran Fatima , El-Khair Adel A.
Published: December 2009

Derivatives of novel thieno[2,3- b][1,6]naphthyridines and thieno[2′,3′: 2,3]pyrido[4,5- d]pyrimidines containing an attached benzotriazole ring have been synthesised.
The Mild Synthesis of Oxime Phosphates by Atherton–Todd Reaction
Authors: Wu Ming Shu , Zhang Xiang Zhu
Published: December 2009

The oximes (1a–i) on reaction with diethyl phosphonates (2) in the presence of triethylamine using chlorocarbons as solvents mildly provide oxime phosphates (3a–i) in good yields and have no the Beckmann rearrangement.
Synthesis of Chromans from the Reaction of O-quinone Methide Precursor with Substituted Styrenes
Authors: Bilgiç Sevim , Bilgiç Orhan , Büyükkıdan Bülent , Gündüz Murat
Published: December 2009

In this work, the inverse-electron demanded Diels–Alder cycloaddition reaction of 1-dimethylaminomethyl-2-naphthol and 2-dimethylaminomethyl-4,5-dimethylphenol with (un)substituted styrenes were investigated. 3,4-Dihydro 2-(un)substitutedphenyl-2H-benzo[f]chromenes and 2-(un)substitutedphenyl-6,7-dimethylchromans were isolated from the reaction of 1-dimethylaminomethyl-2-naphthol and 2-dimethylaminomethyl-4,5-dimethylphenol with (un)substituted styrenes. The yields of the Mannich bases and the reactions of them with (un)substituted styrene appeared to be increased from ortho- to para- substitution.
Synthesis of Chlorohomophthalic Acids, Key Intermediates in the Synthesis of Chlorinated Isocoumarins
Authors: Joseph Augustine R. , Kumbhar Virendra B. , Ranade Anup A. , Paradkar Madhusudan V.
Published: December 2009

Efficient synthesis of chlorohomophthalic acids (6) and (7), key intermediates in the synthesis of chlorinated isocoumarins (3) and (4) is described.
New Scorpionate Oxovanadium Complexes: Syntheses and Crystal Structures of a Series of Vanadium (IV) Complexes with Mixed Ligands of Polypyrazolylborates and Substituted Acetylacetonates
Authors: Xing Yong Heng , Aoki Katsuyuki , Sun Zheng , Ge Mao Fa , Niu Shuyun
Published: December 2009

The reaction of [VO(R1-acac)2] (R1 = Me or Et; acac = acetylacetonate) with Na[HB(pz)3] (pz = pyrazole) or Na[HB(3,5-Me2pz)3] in MeOH gave a series of new oxovanadium (IV) complexes: [VO{HB(pz)3}(Me-acac)] (1), [VO{HB(3,5-Me2pz)3}(Me-acac)] (2), [VO{HB(pz)3}(Et-acac)] (3) and [VO{HB(3,5-Me2pz)3}(Et-acac)] (4), respectively. All complexes have similar distorted octahedral coordination about vanadium, [VO(N3O2)], in which the basal plane is defined by the N4, N6 atoms from the tridentate ligand and the O2, O3 atoms from the R1-acac ligand. However, the dihedral angles between the plane formed by O2, V and O3, and the plane of the pentane-2, 4-dionato ligand (O2, C1, C2, C3 and O3) are variously different; 3.59° for 1, 74.54° for 2, 0.92° for 3, and 29.50° for 4, respectively. In addition, ab initio calculations on 1, 2, 3 and 4 have given the energies and characters of the selected MOs, the atomic net charge and the NBO bond order. The order of stability of the complexes is 1 ≅ 2 ≅ 4 > 3.
Synthesis of Non-cross-linked Polystyrene Supported 5,5-dimethyl Oxazolidinone Chiral Auxiliary
Authors: Wan Yadong , Lu Cuifen , Nie Junqi , Yang Guichun , Chen Zuxing
Published: December 2009

A new chiral auxiliary, non-cross-linked polystyrene supported 5,5-dimethyl oxazolidinone was synthesised in 25.1% yield using L-tyrosine as the starting material using a six-step method.
Zirconium Tetrachloride Mediated Regioselective Transformation of N-tosylaziridines into β-chlorosulfonamides1
Authors: Das Biswanath , Krishnaiah Maddeboina , Laxminarayana Keetha
Published: December 2009

Regioselective ring opening of N-tosylaziridines has efficiently been carried out with ZrCl4 at room temperature to afford the corresponding β-chlorosulfonamides in high yields within a short reaction time.
Novel 13H-indolo[3,2-c]acridines and Their Methyl Derivatives
Authors: Sridharan Makuteswaran , Prasad Karnam Jayarampillai Rajendra
Published: December 2009

7-Phenyl-13H-indolo[3,2-c]acridines (2a–e) have been prepared from 2,3,4,9-tetrahydro-1H-carbazol-1-ones (1a–e) via the intermediate 5,6-dihydro-derivatives (3a–e), and 13H-indolo[3,2-c]acridines (8a–e) from the 1-(N-phenylamino)carbazoles (7a–e). Methylations of 2 and 8 have been carried out, and UV spectral studies on the title compounds and the methylated products are presented, along with plausible mechanisms for the formation of the final compounds.
A Facile Aromatisation of 1,4-dihydropyridines by Ammonium Nitrate in Acetic Acid
Authors: Awachat Moreshwar M. , Shaikh Ajam C. , Ganjave Nitin V. , Chavan Subhash P. , Shivakumar I. , Kalkote Uttam R
Published: December 2009

The oxidation of 1,4-dihydropyridines to pyridines with ammonium nitrate as an oxidant in the presence of acetic acid proceeds in excellent yield.
A New Way to Quinazolines, Perimidines and Dibenzo[d,f][1,3]Diazepines
Authors: Zaleska Barbara , Karelus Marcin , Trzewik Bartosz , Serda Paweł
Published: December 2009

A synthesis of quinazolines, perimidines and dibenzo[d,f][1,3]diazepines is described. The method involves rearrangements following cyclisation of 2-anilino-2-methoxy-3-oxo-N-phenylbutanethioamides with aromatic 1,3-and 1,4-diamines.
Synthesis of Novel, Chiral, Water-soluble Isothiazole Derivatives
Authors: Cież Dariusz , Szneler Edward
Published: December 2009

This article describes an easy preparation of some optically active, water soluble N5,2,3,4-tetrasubstituted isothiazol-5(2H)-imine hydrobromides from modified L-α-amino acids. Isothiazole rings are created in two-step reactions by oxidation of chiral 3-amino-2,3-unsaturated thioamides.
Intramolecular Nucleophilic Assistance in the Solvolyses of Benzyl Derivatives: Solvolyses of O-nitrobenzyl Bromide and Tosylate
Authors: Kevill Dennis N. , Kyong Jin Burm
Published: December 2009

The specific rates of solvolysis of o-nitrobenzyl p-toluenesulfonate (1) have been measured in a wide range of solvents. Comparison with the previously studied para-isomer (2) indicates very similar behaviour (dominant SN2 pathway) in solvents without fluoroalcohol content. With an appreciable fluoroalcohol component, the specific rates are considerably higher than those predicted based on the comparison with the solvolysis of 2 and intramolecular participation by the ortho-nitro group is implicated. Consistent with this postulate, in 97% 2,2,2-trifluoroethanol, the entropy of activation for the solvolysis is considerably less negative for 1 than for 2. Measurements in four representative solvents of the specific rates of solvolysis of the bromides led to kOTs/kBr ratios of 10 to 30, consistent with appreciable nucleophilic assistance (by either solvent or nitro group) in the rate-determining step. For the solvents with an appreciable fluoroalcohol content, an analysis using the extended Grunwald–Winstein equation shows a negligible sensitivity towards changes in solvent nucleophilicity and a low (m = 0.27 ± 0.02) sensitivity towards changes in solvent ionising power. The low m value may result from a favourable solvation of the leaving group being partially counterbalanced by an unfavourable solvation of the nucleophilic nitro group.
Synthesis of 2-[2-hydroxy-2-phenyl-2H-1,4-benzoxazin-3(4H)-ylidene]-1-phenyl-1-ethanones
Authors: Yavari Issa , Mirzaei Anvar , Moradi Loghman , Mokhtarporian-Sanandaj Ako
Published: December 2009

The reaction of 2-aminophenols with dibenzoylacetylene leads to 2-[2-hydroxy-2-phenyl-2H-1,4-benzoxazin-3(4H)-ylidene]-1-phenyl-1-ethanones in 78–90% yields.
Synthesis and Characterisation of Dialkyl[2-(2-phenolato)Oxazolines] of Gallium(III) and Indium(III): Crystal Structure of [{InMe2(OC6H4-OxMe2)}2]
Authors: Ghoshal Shamik , Wadawale Amey , Jain Vimal K. , Nethaji Munirathinam
Published: December 2009

Reactions of trialkylgallium/indium etherate with 2-(2-hydroxyphenyl)oxazolines afforded colourless dialkyl[2-(2-phenolato)oxazoline]gallium/indium complexes of the type [GaR2(OC6H4-OxR′R″)] (1) and [{InMe2(OC6H4-OxR′R″)}2] (2) (R = Me or Et; Ox = oxazoline, R′ = Me or Et; R″ = Me or H). These complexes were characterised by elemental analysis, IR, mass and NMR (1H and 13C) spectral data. The complex [{InMe2(OC6H4-OxMe2)}2] has a dimeric structure as established by X-ray diffraction. The indium atom acquires an irregular trigonal bipyramidal geometry defined by C2O2N ligating atoms.
Clean and Highly Selective Oxidation of Alcohols by the PhI(OAc)2/Mn(TPP)CN/Im Catalytic System
Authors: Karimipour Gholam Reza , Shadegan Hamid Asadpour , Ahmadpour Roxana
Published: December 2009

An efficient method for the oxidation of alcohols is presented. Using catalytic amounts of manganese porphyrin [Mn(TPP)CN] in combination with (diacetoxyiodo)benzene (PhI(OAc)2) allows the conversion of benzylic and primary aliphatic and aromatic alcohols into the corresponding aldehydes, and secondary alcohols to ketones as the sole products. This method provides a cost-effective and environmentally friendly oxidation procedure due to the utilisation of less toxic PhI(OAc)2 and biologically relevant manganese porphyrins. The amounts of the products (%) and the selectivities are very dependent upon the nature of the metalloporphyrin catalysts and also upon the electronic and steric properties of the starting alcohols.
Study on the Stereoselective Reactions of Vinyl(phenyl)Iodonium Salts with Sodium Selenide, Sodium Sulfide, Sodium Azide and Potassium Thiocyanate
Authors: Yan Jie , Jin Hongwei , Chen Zhenchu
Published: December 2009

The reactions of vinyl(phenyl)iodonium salts with sodium selenide, sodium sulfide, sodium azide and potassium thiocyanate have been studied. Divinylic selenides, divinylic sulfides, vinylic azides and vinylic thiocyanates were synthesised stereoselectively in good yields.
Synthesis of Novel Uracil Non-Nucleosides Analogues of 3,4-Dihydro-2-Alkylthio-6-benzyl-4-oxopyrimidines and 6-benzyl-1-ethoxymethyl-5-isopropyluracil
Authors: El-Brollosy Nasser R. , Al-Omar Mohamed A. , Al-Deeb Omar A. , El-Emam Ali A. , Nielsen Claus
Published: December 2009

A series of new uracil non-nucleosides analogues of S-DABO's was synthesised by reaction of 5-alkyl-6-( p-chlorobenzyl)-2-thiouracils with chloroethyl dialkylamine hydrochloride, N-(2-chloroethyl)-pyrrolidine hydrochloride, N-(2-chloroethyl)-piperidine hydrochloride or appropriate haloethers. Novel emivirine analogues were synthesised by silylation of 5-alkyl-6-( p-chlorobenzyl)uracils and treatment with bromomethyl methyl ether, chloromethyl ethyl ether or benzyl chloromethyl ether. Compounds 6-( p-chlorobenzyl)-5-ethyl-1-ethyloxymethyluracil (9e) and 1-benzyloxymethyl-6-(4-chlorobenzyl)-5-ethyluracil (9f) showed activity against wild-type HIV-1 strain III B in MT-4 cells.
Selective Synthesis of Novel Multiimidazole Ligands
Authors: Xiao Rong , Su Xiaoyu , Xie Rugang
Published: December 2009

Novel ligands containing di- to tetra-imidazole rings have been synthesised. 2,2′-Biimidazole was chosen as a dimeric analogue of imidazole which extended the range of ligands.
Simple and Efficient Reduction of Azides to Amines using Recyclable Polymer-Supported Formate and Zinc
Authors: Prakasha Kothathi C. , Sindhumol Methatta , Baba A. Ramesha , Gowda D. Channe
Published: December 2009

Polymer supported formate in conjunction with commercial zinc dust provides a mild and efficient procedure for the reduction of organic azides to corresponding amines. A variety of alkyl and aryl azides were selectively reduced in high yield and purity at room temperature.
The Structures of some Coloured Compounds from Dihydric Phenols and Alkylamines†
Authors: Tyman John H. P. , Patel Mahesh
Published: December 2009

The coloured products from the reaction of resorcinols with methylamine, dimethylamine and other alkylamines have been studied. Phenoxazinones, xantheines and other nitrogenous compounds are formed.
Two New Sesquiterpenoids from Doellingeria Scaber
Authors: Bai Suping , Ma Xingke , Lu Guangzhou , Yan Fulin
Published: December 2009

Examination of Doellingeria scaber collected in China afforded six sesquiterpenoids (1–6) of which two (1 and 4) are new. The structures of two new compounds were established by interpretation of spectroscopic data (IR; HR-MS; 1H, 13C and 2D NMR).
A Stereoselective Total Synthesis of cis-(2R,3S)-3-hydroxypipecolic acid
Authors: Phansavath Phannarath , Haddad Mansour
Published: December 2009

A stereoselective total synthesis of (2 R,3 S)-3-hydroxypipecolic acid starting from an enantiomerically pure α-amino alcohol is reported. The synthesis involved a regioselective mesylation and subsequent cyclisation as key steps.
p-Toluenesulfonic Acid–Celite as a Reagent for Synthesis of Esters of Alkylphosphonic Acids under Solvent-Free Conditions
Authors: Gupta Arvind K. , Kumar Rajesh , Dubey Devendra K. , Kaushik M.P.
Published: December 2009

The coupling reaction of alkylphosphonic acids and alcohols on the surface of p-toluenesulfonic acid–Celite under mild and solvent-free conditions gave the corresponding phosphonates in excellent yields. This method provides a useful rapid synthesis of phosphonates for use in the unambiguous identification of chemical warfare agents.
N,N′-Dichlorobis(2,4,6-trichlorophenyl)urea (CC-2): An Efficient Reagent for Conversion of Oximes to Ketones
Authors: Gupta Arvind K. , Pardasani Jyotiranjan Acharya Deepak , Dubey Devendra K.
Published: December 2009

A method for the rapid conversion of oximes into the corresponding carbonyl compounds using N,N′-dichlorobis (2,4,6-trichlorophenyl)urea (CC-2) at room temperature is described. The method is economical as the solid byproduct bis(2,4,6-trichlorophenyl)urea could be removed by filtration and recycled after re-chlorination.
Carbon–Carbon Bond Cleavage and Esterification of Phenylacetonitrile and its Derivatives Affording the Corresponding Benzoic Esters
Authors: Wang Zhiyuan , Kang Junhui , Yu Mingxin
Published: December 2009

Phenylacetonitrile and its derivatives were treated with alcohols in the presence of potassium iodide and iodine affording the corresponding benzoate esters via degradation, oxidation and esterification under mild conditions. The products were characterised by IR, 1H NMR, MS and elemental analysis.
Synthesis and Anti-HBV Activity of Isocytosine Derivatives linked to 5-position of methyl β-D-ribofuranoside
Authors: Abdel-Rahman Adel A.-H.
Published: December 2009

A series of isocytosine derivatives linked to the 5-position of methyl β-D-ribofuranoside were synthesised. The new compounds were evaluated in vitro for cytotoxicity against hepatitis B virus (HBV) and showed moderate activity.
Microwave assisted Synthesis and Biological activities of 9-boronobenzyladenine derivatives
Authors: Yu Xue-Jun , Liu Wei , Hu Wei-Dong , Dong Xue-Liang , Xu Dan , Deng You-Quan
Published: December 2009

Microwave enhanced syntheses of 9-boronobenzyladenine derivatives by the reaction of adenine with the corresponding bromomethylphenylboric acid were reported. Microwave irradiation reduced the overnight reaction time of conventional thermal methods to 10 min, provided the desired products and increased the yields up to three times. Preliminary in vitro pharmacological tests were also described.
Facile Access to Labdane-type Diterpenes: Synthesis of Coronarin C, Zerumin B, Labda-8(17), 13(14)-dien-15,16-olide and derivatives from (+)-manool
Authors: Villamizar José E. , Juncosa José , Pittelaud Jean , Hernández Madeleyn , Canudas Nieves , Tropper Eleonora , Salazar Franklin , Fuentes Juan
Published: December 2009

A practical method for the synthesis of optically active labdane-type diterpenes from (+)-manool 8, is described. We prepared the natural labdane-type diterpene 5 via key intermediate peroxide 9 and coronarin C 1, compound 8 and zerumin B 6 via a furan photosensitised oxygenation reactions.
Two New Diterpenoids and other constituents from Isodon serra
Authors: Yan FuLin , Zhang LaiBin , Zhang JiXia , Sun HanDong
Published: December 2009

Two new ent-6,7-seco-kaurane-type diterpenoids, 15α,20β-dihydroxy-6β-methoxy-6,7-seco-6,20-epoxy-ent-kaur-16-en-1,7-olide (1), 6α,15α-dihydroxy-20-aldehyde-6,7-seco-6,11α-epoxy-ent-kaur-16-en-1,7-olide (2), together with seven known diterpenoids, enmein (3), nodosin (4), isodocarpin (5), nervosin (6), epinodosin (7), epinodosinol (8) and rabdosin (9) were isolated from the aerial part of Isodon serra. Their structures were elucidated by spectroscopic means.
Synthesis of Functionalised Zirconium Complexes
Authors: Zhang Ming , Zhang Ai-Qin
Published: December 2009

A method for synthesis of cyclic zirconium complexes has been developed. Treating zirconocene complexes having aryl methyl ether substituted ligands with BBr3 affords cyclic zirconium complexes.
Catalytic Oxidation of 1,4-dihydropyridins by Tetrabutylammonium Periodate in the presence of Manganese Amino Acid Schiff Base
Authors: Karimipour Gholam Reza , Nasr-Esfahani Masoud , Valipour Ghasem
Published: December 2009

The amino acid Schiff base manganese complex (Tryp–Mn); 1, was prepared with L-tryptophan, salicylaldehyde and Mn(OAc)2.4H2O in methanol. In the presence of 1, 1,4-dihydropyridines (1,4-DHPs) were oxidised by n-Bu4NIO4 to the corresponding pyridine derivatives in high yields. Imidazole was used as an additive to improve the catalytic oxidation.
One-Flask Synthesis of Porphyrin Metal Complexes
Authors: Manda Amaravathi , Maradolla Mohan Babu , Garimella Chandramouli , Lingamallu Giribabu
Published: December 2009

One-flask synthesis of metallo porphyrins by condensation of aromatic aldehydes with pyrrole in refluxing propionic acid in presence of corresponding metal acetates is described. The yields are better when compared to Rothemund and Adler–Longo methods.
Medium-sized Cyclophanes. Part 76.1 Synthesis of syn-9-methoxy (1,4)naphthaleno[3.3]metacyclophanes and their charge-transfer Complexes with Tetracyanoethylene in CH2Cl2
Authors: Hu Jian-yong , Ueno Ryuji , Miyazaki Minoru , Yamato Takehiko
Published: December 2009

The charge-transfer band of syn-9-methoxy(1,4)naphthaleno[3.3]metacyclophanes with tetracyanoethylene in CH2Cl2 are observed in the range of 604–606 nm, which is arising from the exclusive formation on the naphthalene ring due to the expanded π-electron density as well as the steric hindrance of the inner methoxy group at 9-position.
Structure and Conformational Properties of three-layered Cyclophanes prepared by a one-pot Synthesis
Authors: Tsuge Akihiko , Okamoto Takahiro , Moriguch Tetsuji
Published: December 2009

The coupling reactions of substituted bis(bromomethyl)benzene components and tetra(mercaptomethyl)benzene derivatives have been carried out under heterogeneous dilute reaction conditions to afford the three-layered cyclophanes 3a–e as three kinds of conformational isomers in moderate yields.
Substituted Hydrazonals as Building Blocks in Heterocyclic Synthesis: A New Route to Arylhydrazonocinnolines
Authors: Al-Shiekh Mariam A. , Medrassi Hanady Y. , Elnagdi Mohamed H. , Hafez Ebtisam A.
Published: December 2009

2-heteroylhydrazonopropanals 2a–e and 3-oxo-2-arylhydrazonopropanals 2f–k were prepared via coupling of enaminones 1 with aromatic diazonium salts. Compounds 2a–c condensed with hydrazine hydrate to yield the corresponding hydrazones 3a–c which afford on cyclisation the cinnoline derivatives 6a–c, while condensation of 2g, j with hydrazine hydrate directly yielded the pyrazole derivatives 4g–j. Condensation of 2a–c, f, g with phenyl hydrazine gave the corresponding phenyl hydrazone derivatives 7a–c, f, g. Structures of 2a, h and 3a were assessed by single crystal X-ray analyses.