bluuebunny/crossref_metadata_2025 huggingface dataset:
DYNAMIC COMPRESSIBILITY OF BIRCH AT DIFFERENT TYPES OF STRESS-STRAINED STATE
Authors: Bragov A.M. , Lomunov A.K. , Yuzhina T.N.
Published: October 2020

The results of dynamic tests for compression across the fibers at room temperature of birch samples with air humidity are presented. Dynamic tests were carried out on a setup with a split Hopkinson bar according to the Kolsky method at a strain rate of ~2000 s–1. To assess the effect of the type of stress-strain state on the behavior of the material, in addition to specimens in the form of cylinders with its free expansion during loading (uniaxial stress state condition), specimens were tested in a rigid casing that prevents the radial expansion of the specimen (uniaxial deformation condition), as well as local compressive tests of rectangular board fragments. In the latter case, the material surrounding the loading zone plays the role of a compliant confining casing. In this case, a certain intermediate stress-strain state is realized in the sample. For these three types of stress-strain state, dynamic deformation diagrams were obtained with registration of additional loading cycles. Comparison of obtained deformation diagrams shows a significant effect of the type of stress-strain state on the behavior of the material under study. In the case of free expansion of the specimen in the radial direction, the absence of strain hardening is observed in the first loading cycle. In subsequent cycles, hardening is negligible. The deformation diagrams of specimens in the casing as well as board fragments are characterized by a noticeable increase in the modulus of the hardening branch with increasing deformation. In this case, it can be noted that the behavior of the material in the case of testing a piece of board is intermediate between the cases of uniaxial stress state and uniaxial strain state. Some mechanical characteristics of the material are determined using the diagrams obtained. The obtained experimental results can serve as the basis for the subsequent identification of the model of deformation and destruction of wood.
AN EXPERIMENTAL STUDY OF THE PENETRATION OF CYLINDRICAL PROJECTILES INTO DRY SAND
Authors: Balandin V.V. , Balandin Vl.Vl. , Parkhachev V.V.
Published: October 2020

For the most complete study of the laws of shock interaction of solids with soil barriers, further development of experimental techniques for recording the parameters of the interaction process in direct and inverse experiments is necessary. In this work, to determine the parameters of the movement of the projectile (displacement and speed) in a direct experiment, a millimeter-wave radio interferometer is used. This method allows continuous recording of the movement of the rear end of the striker with high accuracy over a wide range of movements. Using the proposed technique, experiments were carried out to record the motion parameters of cylindrical impactors made of steel and aluminum alloy when interacting with an obstacle made of dry sand. At the same time, the movement of the rear end of the striker was also controlled using high-speed filming until the full immersion of the striker. The experiments showed that the measurement results obtained using two methods coincide within the measurement error. Based on the experiments, it can be concluded that the methodology for determining the displacement and velocity of a projectile in a ballistic experiment using a millimeter-wave radio interferometer allows continuous measurement of large displacements (100 mm or more), including when completely immersed in a target with sufficient practical goals accuracy. Based on the results of the experiments, the dependences of the movement of the projectile and its speed on time are constructed. A change in the penetration law was found with a decrease in the penetration velocity to values less than 100 m/s.
Distinct Cognitive Trajectories in Late Life and Associated Predictors and Outcomes: A Systematic Review
Authors: Wu Zimu , Phyo Aung Zaw Zaw , Al-harbi Tagrid , Woods Robyn L. , Ryan Joanne
Published: October 2020

Background:

Cognitive aging is a dynamic process in late life with significant heterogeneity across individuals.

Objective:

To review the evidence for latent classes of cognitive trajectories and to identify the associated predictors and outcomes.

Methods:

A systematic search was performed in MEDLINE and EMBASE for articles that identified two or more cognitive trajectories in adults. The study was conducted following the PRISMA statement.

Results:

Thirty-seven studies were included, ranging from 219 to 9,704 participants, with a mean age of 60 to 93.4 years. Most studies ( n = 30) identified distinct cognitive trajectories using latent class growth analysis. The trajectory profile commonly consisted of three to four classes with progressively decreasing baseline and increasing rate of decline—a ‘stable-high’ class characterized as maintenance of cognitive function at high level, a ‘minor-decline’ class or ‘stable-medium’ class that declines gradually over time, and a ‘rapid-decline’ class with the steepest downward slope. Generally, membership of better classes was predicted by younger age, being female, more years of education, better health, healthier lifestyle, higher social engagement and lack of genetic risk variants. Some factors (e.g., education) were found to be associated with cognitive function over time only within individual classes.

Conclusion:

Cognitive aging in late life is a dynamic process with significant inter-individual variability. However, it remains unclear whether similar patterns of cognitive aging are observed across all cognitive domains. Further research into unique factors which promote the maintenance of high-cognitive function is needed to help inform public policy.
A three-week intervention emphasized diagonal eccentric contraction on balance and joint position sense and ankle strength in subjects with ankle instability: A randomized controlled trial
Authors: Park Du-Jin , Kim Byeong-Jo , Kim Yong-Hun , Park Se-Yeon
Published: October 2020

BACKGROUND: Problems related to ankle instability, decreased proprioceptive sensation, altered static and dynamic balance abilities are suggested as major representative factors that contribute to the recurrence of ankle sprains. OBJECTIVE: To assess the effect of a three-week intervention (intervention emphasizing diagonal eccentric contraction (IEDEC) and intervention of general exercise (IGE)) on static and dynamic balance abilities, ankle strength and joint position sense at pre- and post-intervention, and at two- and three-week post-intervention. METHODS: Twenty-five participants with ankle instability, including a history of ankle sprain and recurrent episodes of giving way, were enrolled in the study. They were randomly classified into the IEDEC group (n= 12) and the IGE group (n= 13). Dynamic balance was examined using the Y Balance Test, four-way ankle strength was measured, and the static balance was evaluated using the total displacement of the center of pressure (COP). To identify the joint position error, eversion and inversion of the ankle angle were measured. RESULTS: The results revealed significant increases in ankle dynamic stability and strength at two and three weeks post-intervention (p< 0.05). Similarly, the total displacement of the COP differed significantly over time, with a higher COP during the initial measurement than at two and three weeks intervention (p< 0.05) General balance training with IEDEC can improve position sense during ankle inversion (p< 0.05). CONCLUSION: General balance training with IEDEC improved the position sense of the inversion. Combined therapeutic intervention, such as with the manual technique, could be a beneficial approach to maximize the treatment effects.
LncRNA HOTAIR promotes breast cancer progression through regulating the miR-129-5p/FZD7 axis
Authors: Wu Dongdi , Zhu Jia , Fu Ying , Li Chenqin , Wu Biao
Published: October 2020

Breast cancer is the most common malignancies worldwide. LncRNA HOX transcript antisense intergenic RNA (HOTAIR) has been shown to promote progression and metastasis of various cancers, including breast cancer. This reasearch aimed to investigate the downstream regulatory pathways of HOTAIR in breast cancer. The levels of HOTAIR and miR-129-5p were examined in breast cancer tissues and SKBR3 and MCF7 cells by quantitative real-time PCR (qRT-PCR). Cell proliferation was examined by Cell Counting Kit-8 (CCK-8) assay. Cell migration and invasion were estimated by transwell assay. Epithelial-to-mesenchymal transition (EMT)-related markers (E-cadherin, N-cadherin and Vimentin) were measured by Western blot assay. The expression of Frizzled 7 (FZD7) was detected using qRT-PCR or Western blot assay. Bioinformatics analysis, luciferase reporter assay or RNA Immunoprecipitation (RIP) assay was performed to explore the molecular mechanism of HOTAIR in breast cancer. Xenograft analysis was utilized to evaluate the tumor growth in vivo. HOTAIR and FZD7 were upregulated, while miR-129-5p was down-regulated in breast cancer tissues and cells. Knockdown of miR-129-5p reversed the effect of HOTAIR knockdown on cell proliferation, migration, invasion and EMT. FZD7 restored the inhibition of miR-129-5p on breast cancer progression. Furthermore, HOTAIR was a sponge of miR-129-5p and FZD7 was a target of miR-129-5p. Knockdown of HOTAIR inhibited the tumor growth in vivo. HOTAIR facilitated breast cancer progression by regulating the miR-129-5p/FZD7 axis, indicating that HOTAIR may be a potential biomarker and therapeutic target for breast cancer.
Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis
Authors: Shen Daqing , Xu Jing , Cao Xiande , Cao Xianxiang , Tan Hailin , Deng Huanghao
Published: October 2020

BACKGROUND: Long noncoding RNA (lncRNA) are critical regulators of tumor progression. OBJECTIVE: To determine how the lncRNA membrane associated guanylate kinase, WW and PDZ domain-containing 2 (MAG12) antisense RNA 3 (MAGI2-AS3) and the phosphatase and tensin homolog (PTEN) gene function in regulating bladder cancer (Bca) progression. METHODS: Total RNA from 80 Bca tissues and 30 paired para-cancerous tissues from patients was sequentially extracted, quantified, purified, and reverse transcribed using RT-PCR. A library was constructed and sequenced. Four Bca cell lines and a normal urothelial cell line were transfected with lentiviral plasmids, and cell migration and invasion were assayed in vitro. An orthotopic mouse model of Bca was created for in vivo studies. RESULTS: MAGI2-AS3 expression was significantly downregulated in Bca, compared with normal tissues, and negatively associated with tumor stage and a poor prognosis. MAGI2-AS3 and its sense RNA MAGI2 showed significant and positive correlation. The expression of MAGI2 and its downstream gene, PTEN, increased in Bca cells overexpressing MAGI2-AS3, and interference by MAGI2 expression reversed the migration and invasion inhibited by MAGI2-AS3 overexpression. CONCLUSION: MAGI2-AS3 overexpression inhibited Bca cell progression by regulating the MAGI2/PTEN/epithelial-mesenchymal transition, offering novel insights into the mechanism of Bca progression.
Mining database for the therapeutic targets and prognostic biomarkers among STAT family in glioblastoma
Authors: Li Chenglin , Zhou Yanfei , Deng Hanshun , Ye Yuanshen , Zhao Shuizhen , Liang Shangnan , Cai Shirong , Lin Jincai , Tang Yaolong , Wu Yanyu
Published: October 2020

BACKGROUND: Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor with a high mortality rate. Aberrant activation of signal transducers and activators of transcription (STAT) signaling results in tumor pathogenesis and progression by regulating cell cycle, cell survival and immune response. METHODS: Therapeutic targets and prognostic biomarkers within the STAT family in GBM were explored using web applications and databases. RESULTS: High levels of STAT1/3/5A/5B/6 and low levels of STAT4 were observed in GBM patients. GBM patients expressing high STAT1/2/3/5A/6 and low STAT4/5B levels had the worse overall survival. Among the STAT family, STAT4 and STAT6 were the most frequently mutated genes. A low to moderate correlation among members of the STAT family was observed. Additionally, the STATs were involved in activation or inhibition of cancer related pathways. Analysis of immune infiltrates showed STAT5A levels to be significantly correlated with abundance of immune cells and levels of immune gene biomarkers. Gene ontology (GO) functions and KEGG pathway analysis indicated that STAT5A is involved in immune response-regulating signaling pathway, neutrophil and lymphocyte mediated immunity, single-stranded DNA binding, cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, NF-kappa B signaling pathway and TNF signaling pathway. Moreover, several kinase and transcription factor targets of STAT5A in GBM were identified. CONCLUSION: We report here therapeutic targets, prognostic biomarkers and regulation network of STAT family in GBM. These findings lay a foundation for further studies on the role of STAT family in therapy and prognosis of GBM. Further studies are required to verify our results.
Circular RNA circ_0000039 enhances gastric cancer progression through miR-1292-5p/DEK axis
Authors: Fan Dengguo , Wang Changjiang , Wang Deyuan , Zhang Ning , Yi Tao
Published: October 2020

BACKGROUND: Circular RNA (circRNA) is a class of non-coding RNA that is vital for regulating gene expression and biological functions. Mounting studies demonstrate that circRNA is crucial for human cancer development. However, the role of circ_0000039 in gastric cancer (GC) remains uncertain. METHODS: Normal human gastric tissues and GC tissue samples were collected, and quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect the expression levels of circ_0000039, miR-1292-5p, and DEK. GC cell lines with overexpression and low expression of circ_0000039 were constructed. Cell counting kit-8 (CCK-8), scratch healing and Transwell experiments were used to assess the function of circ_0000039 on the proliferation, migration and invasion of GC cells. Bioinformatics analysis and dual-luciferase reporter assays were employed to detect the targeting relationship between circ_0000039 and miR-1292-5p. RESULTS: Circ_0000039 expression was up-regulated in GC tissues and cell lines, and it was significantly related with poor differentiation of tumor tissues. In addition, circ_0000039 overexpression enhanced the proliferation, migration and invasion of GC cells, while circ_0000039 depletion inhibited these malignant biological behaviors. In terms of mechanism, it was found that circ_0000039 promoted the proliferation and progression of GC cells by adsorbing miR-1292-5p and up-regulating the expression of DEK. CONCLUSION: Circ_0000039 is a new oncogenic circRNA in GC, which regulates the miR-1292-5p/DEK axis to modulate the malignant biological behaviors of GC.
PET Amyloid and Tau Status Are Differently Affected by Patient Features
Authors: Tan Meng-Shan ,   Alzheimer’s Disease Neuroimaging Initiative, Yang Yu-Xiang , Wang Hui-Fu , Xu Wei , Tan Chen-Chen , Zuo Chuan-Tao , Dong Qiang , Tan Lan , Yu Jin-Tai
Published: October 2020

Background: Amyloid-β (Aβ) plaques and tau neurofibrillary tangles are two neuropathological hallmarks of Alzheimer’s disease (AD), which both can be visualized in vivo using PET radiotracers, opening new opportunities to study disease mechanisms. Objective: Our study investigated 11 non-PET factors in 5 categories (including demographic, clinical, genetic, MRI, and cerebrospinal fluid (CSF) features) possibly affecting PET amyloid and tau status to explore the relationships between amyloid and tau pathology, and whether these features had a different association with amyloid and tau status. Methods: We included 372 nondemented elderly from the Alzheimer’s Disease Neuroimaging Initiative cohort. All underwent PET amyloid and tau analysis simultaneously, and were grouped into amyloid/tau quadrants based on previously established abnormality cut points. We examined the associations of above selected features with PET amyloid and tau status using a multivariable logistic regression model, then explored whether there was an obvious correlation between the significant features and PET amyloid or tau levels. Results: Our results demonstrated that PET amyloid and tau status were differently affected by patient features, and CSF biomarker features provided most significant values associating PET findings. CSF Aβ42/40 was the most important factor affecting amyloid PET status, and negatively correlated with amyloid PET levels. CSF pTau could significantly influence both amyloid and tau PET status. Besides CSF pTau and Aβ42, APOE ɛ4 allele status and Mini-Mental State Examination scores also could influence tau PET status, and significantly correlated with tau PET levels. Conclusion: Our results support that tau pathology possibly affected by Aβ-independent factors, implicating the importance of tau pathology in AD pathogenesis.
Impairment of Everyday Spatial Navigation Abilities in Mild Cognitive Impairment Is Weakly Associated with Reduced Grey Matter Volume in the Medial Part of the Entorhinal Cortex
Authors: Hallab Asma ,   for the Alzheimer’s Disease Neuroimaging Initiative, Lange Catharina , Apostolova Ivayla , Özden Cansu , Gonzalez-Escamilla Gabriel , Klutmann Susanne , Brenner Winfried , Grothe Michel J. , Buchert Ralph
Published: October 2020

Background: Research in rodents identified specific neuron populations encoding information for spatial navigation with particularly high density in the medial part of the entorhinal cortex (ERC), which may be homologous with Brodmann area 34 (BA34) in the human brain. Objective: The aim of this study was to test whether impaired spatial navigation frequently occurring in mild cognitive impairment (MCI) is specifically associated with neurodegeneration in BA34. Methods: The study included baseline data of MCI patients enrolled in the Alzheimer’s Disease Neuroimaging Initiative with high-resolution structural MRI, brain FDG PET, and complete visuospatial ability scores of the Everyday Cognition test (VS-ECog) within 30 days of PET. A standard mask of BA34 predefined in MNI space was mapped to individual native space to determine grey matter volume and metabolic activity in BA34 on MRI and on (partial volume corrected) FDG PET, respectively. The association of the VS-ECog sum score with grey matter volume and metabolic activity in BA34, APOE4 carrier status, age, education, and global cognition (ADAS-cog-13 score) was tested by linear regression. BA28, which constitutes the lateral part of the ERC, was used as control region. Results: The eligibility criteria led to inclusion of 379 MCI subjects. The VS-ECog sum score was negatively correlated with grey matter volume in BA34 (β= –0.229, p = 0.022) and age (β= –0.124, p = 0.036), and was positively correlated with ADAS-cog-13 (β= 0.175, p = 0.003). None of the other predictor variables contributed significantly. Conclusion: Impairment of spatial navigation in MCI is weakly associated with BA34 atrophy.
Randomized Controlled Trial of Multi-Component Cognitive Stimulation Therapy (SADEM) in Community-Dwelling Demented Adults
Authors: Juárez-Cedillo Teresa , Gutiérrez-Gutiérrez Lidia , Sánchez-Hurtado Luis Alejandro , Martínez-Rodríguez Nancy , Juarez-Cedillo Enrique
Published: October 2020

Background: Dementia is a persistent, progressive state of cognitive decline against which pharmacological intervention has a modest efficacy, reducing behavioral but not cognitive symptoms. Therefore, different non-pharmacological therapies have been developed; the most scientifically recognized are cognitive therapies that have improved cognitive function and daily life activities. Objective: To evaluate the effectiveness of a multicomponent cognitive stimulation therapy (SADEM) on cognitive and behavioral function and daily life activities in patients with mild stage dementia. Methods: Controlled clinical trial with pre- and post-intervention (12 months) and follow-up (24 months after) evaluations. Participants (67) diagnosed with mild dementia were randomly assigned to intervention group (n = 39) or control group (n = 28). The intervention took place throughout one year and consisted of two weekly 90-minute sessions and one more a year after a monthly follow-up. Instruments were used to evaluate outcomes in cognitive, behavioral, and affective domains. Results: The results showed statistically significant differences, with improvement in the cognitive outcomes and the Dementia Index post-intervention (p = 0.01). No progression of the disease was observed at the end of the study. Conclusion: The multicomponent intervention tested had positive effects on cognitive and behavioral functions and daily life activities in people with mild stage dementia, delaying progression for at least two years.
Mesenchymal Stem Cell-Conditioned Medium Improves Mitochondrial Dysfunction and Suppresses Apoptosis in Okadaic Acid-Treated SH-SY5Y Cells by Extracellular Vesicle Mitochondrial Transfer
Authors: Zhang Zhihua , Sheng Hongxia , Liao Li , Xu Chen , Zhang Ang , Yang Yang , Zhao Long , Duan Lian , Chen Hu , Zhang Bin
Published: October 2020

Background: Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising cell-free therapy for Alzheimer’s disease (AD) mainly due to the paracrine of MSCs, but the precise mechanisms remain unclear. Studies suggests that mitochondrial dysfunction precedes the accumulation of amyloid-β plaques and neurofibrillary tangles, and involves in the onset and development of AD. Objective: In the present study, we evaluated the protective effects and explored the related-mitochondrial mechanisms of human umbilical cord derived MSC-CM (hucMSC-CM) in an AD model in vitro. Methods: To this end, an AD cellular model was firstly established by okadaic acid (OA)-treated SH-SY5Y cells, and then treated by hucMSC-CM to assess the oxidative stress, mitochondrial function, apoptosis, AD-related genes, and signaling pathways. Results: hucMSC-CM significantly deceased tau phosphorylated at Thr181 (p181-tau) level, which was increased in AD. hucMSC-CM also alleviated intracellular and mitochondrial oxidative stress in OA-treated SH-SY5Y cells. In addition, hucMSC-CM suppressed apoptosis and improved mitochondrial function in OA-treated SH-SY5Y cells. Flow cytometric analysis indicated that hucMSC-CM exerted the protective effects relying on or partly extracellular vesicle (EV) mitochondrial transfer from hucMSCs to OA-treated SH-SY5Y cells. Moreover, RNA sequencing data further demonstrated that hucMSC-CM regulated many AD-related genes, signaling pathways and mitochondrial function. Conclusion: These results indicated that MSC-CM or MSC-EVs containing abundant mitochondria may provide a novel potential therapeutic approach for AD.
Self-Reported Hearing Loss and Longitudinal Cognitive Function in a Cohort Enriched with Risk for Alzheimer’s Disease
Authors: Fields Taylor N. , Mueller Kimberly D. , Koscik Rebecca L. , Johnson Sterling C. , Okonkwo Ozioma C. , Litovsky Ruth Y.
Published: October 2020

Background: Growing evidence suggests hearing loss is a risk factor for mild cognitive impairment and dementia, but few studies have examined its relationship to sub-clinical cognitive outcomes. Objective: To investigate the effect of self-reported hearing loss on longitudinal cognitive function in a risk-enriched cohort of clinically-unimpaired, late middle-aged adults. Methods: 579 participants from the Wisconsin Registry for Alzheimer’s Prevention (WRAP) were included. Hearing status was determined via self-reported history of diagnosed hearing loss. Each participant with self-reported hearing loss was age- and sex-matched to two participants who never reported hearing loss using nearest-neighbor matching. Linear mixed-effects models were used to examine associations between self-reported hearing loss and age-related cognitive trajectories with covariates of sex, literacy, and ethnicity, person-level random intercepts and age-related slopes. Cognitive outcomes encompassed measures of speed and flexibility, visuospatial memory, and verbal fluency. Results: Participants with self-reported hearing loss exhibited significantly poorer performance on a speed and flexibility factor score and single test of psychomotor speed and executive function, relative to participants who never reported hearing loss. There was no association between self-reported hearing loss and visuospatial memory or verbal fluency. Longitudinally, self-reported hearing loss was associated with less rapid decline in speed and flexibility and no difference in rate of decline for any other cognitive measure. Conclusion: Self-reported hearing loss was associated with poorer speed and flexibility but not with accelerated decline in any domain studied, contrary to previous findings. Further studies involving behavioral auditory measures in this cohort would clarify the robustness of these findings.
Application of fuzzy control harmonic suppression and reactive power compensation technology for power electronic equipment based on cloud computing
Authors: Duan Zhimei , Yuan Xiaojin , Zhu Rongfei
Published: October 2020

Harmonic pollution and reactive power consumption are the two most important factors affecting power quality. Power electronics, as the largest harmonic source, will produce a large number of harmonics while running, and will also lose reactive power, reduce the power factor of the system and affect power quality. Firstly, the current situation of reactive power and harmonic suppression based on fuzzy control is briefly introduced. Then, the harmonic component and power factor of the power grid are taken as two objective functions to model the power grid. The improved particle swarm optimization (PSO) genetic algorithm is used to establish the harmonic suppression and reactive power compensation model. To improve the design efficiency, aiming at the complexity of the algorithm and the field measurement data, the reactive power compensation device is quickly solved on the Hadoop cloud computing platform to achieve the global optimal compensation effect, to improve the convergence speed and global search ability of the particle swarm optimization algorithm. Thus, based on ensuring the power factor, the harmonic component is restrained and the safety and reliability of power grid operation are improved.
Research on user satisfaction of third-party mobile payment under the IoT environment——based on the structural equation mode
Authors: Li Chunya , Li Yan
Published: October 2020

This paper establishes a theoretical model of third-party mobile payment user satisfaction based on the ASCI model and proposes research hypotheses. Then, the questionnaire survey method is used to collect sample data and carry out reliability and validity test. After the test is passed, structural equation modeling (SEM) is used to verify the research model and hypothesis. Finally, the analysis concludes: perceived quality and perceived value will have a positive impact on user satisfaction; user expectations will affect user satisfaction through perceived quality and perceived value; the impact of perceived risk on user satisfaction is not obvious. Propose reasonable suggestions for third-party mobile payment companies based on the research conclusions.
Various operations and right completeness in generalized residuated lattices
Authors: Ko Jung Mi , Kim Yong Chan
Published: October 2020

In this paper, based on generalized residuated lattices as an extension of Zhang’s complete residuated lattices, there are two types of structures: bi-partially orders, right (left) joins, right (left) complete lattices and right (left) Alexandrov topologies. We investigate their properties and the relationship between them. Moreover, monotone maps, right (left)-embedding maps and right-join (left-join) preserving maps are investigated with various operations as extensions of Zadeh powerset operations between these structures. As the foundation of fuzzy rough sets and fuzzy contexts, there exist adjunctions and Galois connections between maps from right(left) Alexandrov topologies to right(left) Alexandrov topologies. We give their examples.
Fuzzy Galois connections on Alexandrov L-topologies
Authors: Oh Ju-Mok , Kim Yong Chan
Published: October 2020

In this paper, we introduce the notion of Galois and dual Galois connections as a topological viewpoint of concept lattices in a complete residuated lattice. Under various relations, we investigate the Galois and dual Galois connections on Alexandrov L-topologies. Moreover, their properties and examples are investigated.
Information structures and uncertainty in an image information system
Authors: Zhang Gangqiang , Li Zhaowen , Zhang Pengfei , Xie Ningxin
Published: October 2020

An information system as a database that stands for relationships between objects and attributes is an important mathematical model. An image information system is an information system where each of its information values is an image and its information structures embody internal features of this type of information system. Uncertainty measurement is an effective tool for evaluation. This paper explores measures of uncertainty for an information system by using the proposed information structures. The distance between two objects in an image information system is first given. After that, the fuzzy Tcos-equivalence relation, induced by this system by using Gaussian kernel method, is obtained, where Gaussian kernel is based on this distance. Next, information structures of this system are described by set vectors, dependence between information structures is studied and properties of information structures are given by using inclusion degree, and application for information structures and uncertainty measures of an image information system are investigated by the information structures. Moreover, effectiveness analysis is done to show the feasibility of the proposed measures from the angle of statistics. Finally, an application of the proposed measurement for attribute reduction is given. These results will be helpful for understanding the essence of uncertainty in an image information system.
Statistical Convergence of order β for (λ, μ) double sequences of fuzzy numbers
Authors: Barlak Damla
Published: October 2020

In this study, we introduce the concepts of φλ,μ-double statistically convergence of order β in fuzzy sequences and strongly λ- double Cesaro summable of order β for sequences of fuzzy numbers. Also we give some inclusion theorems.
Fast neutrons at LNL Legnaro
Authors: Mastinu Pierfrancesco , Bisello Dario , Barrera Rogelio Alfonso , Porras Ignacio , Prete Gianfranco , Silvestrin Luca , Wyss Jeffery
Published: October 2020

In this contribution we describe NEPIR, the fast-neutron irradiation facility under construction at the 70 MeV cyclotron SPES facility of the INFN laboratory of Legnaro (LNL). NEPIR will be constructed in stages, according to the available funds. The initial configuration, based on a thick Be neutron production target, will be operational in 2022; it will be used for shielding studies against fast neutrons for space applications and to investigate neutron-induced Single Event Effects (SEE) in microelectronic devices and systems. In its final configuration NEPIR will have two target systems: one will deliver a Quasi Mono-energetic Neutron (QMN) beam, of general interest, with an adjustable energy peak in the 20–70 MeV range; the second target will deliver a specialized continuous energy neutron beam for studying the effects of fast neutrons produced in cosmic ray air-showers in electronic devices and systems. We review the use of NEPIR to characterize the sensitivity of electronics, describe the neutron production targets and the facility layout. In closing we describe ways, presently under investigation, to use the 15 MV XTU Tandem of LNL to produce nearly monochromatic fast neutrons that would complement the QMN system by allowing one to probe for SEE below 20 MeV.
PEMBUATAN BRIKET DARI KULIT BUAH MAHONI DENGAN VARIASI JENIS DAN KONSENTRASI PEREKAT
Authors: Indrawijaya Budhi
Published: October 2020

Kulit buah mahoni merupakan bagian pada tanaman mahoni yang tidak dimanfaatkan, dengan demikian pemanfaatannya untuk membuat briket adalah solusi dijadikan bahan bakar. Penelitian ini bertujuan untuk mengetahui apakah kulit buah mahoni bisa diarangkan serta menentukan konsentrasi dan jenis perekat yang tepat agar briket yang dihasilkan berkualitas paling baik sesuai dengan SNI 01-6235-2000. Biomassanya diperoleh dari desa tirtosworo, Wonogiri. Penelitian ini menggunakan metode eskperimen di laboratorium dengan beberapa tahap, yaitu (1) penjemuran biomassa; (2) pirolisis; (3) Perekatan; (4) Pembentukan; (5) Analisa kualitas briket. Variabel penelitian meliputi jenis perekat yaitu tepung tapioka dan tepung jagung serta konsentrasi tepung pada perekat yaitu 10%, 15%, 20% serta 25% dari total lem yang dihasilkan, dengan perbandingan arang dan lem 2:3. Hasil penelitian diperoleh bahwa kulit buah mahoni bisa diarangkan sehingga bisa dijadikan bahan utama briket dengan jenis perekat yaitu tepung tapioka 25% yang karakteristik briketnya : (a) kadar air 2,7731%; (b) kadar abu 7,4227%; (c) kadar zat menguap 14,2192%; dan (d) kadar karbon terikat 75,5850%.
KARAKTERISASI PEMBUATAN PEMBUATAN EDIBLE FILM DENGAN VARIABEL KOMBINASI TEPUNG KONJAK DAN KARAGENAN SERTA KONSENTRASI GLISEROL
Authors: Ansari Irman
Published: October 2020

Penggunaan plastik sebagai kemasan produk menyebabkan meningkatnya beban lingkungan karena sulit mendegradasikan plastic tersebut. Tuntutan untuk menjaga lingkungan menjadi pemicu  melakukan penelitian untuk membuat substitusi plastic yang ramah lingkungan. Edible film dari bahan baku karagenan ( yang berasal dari rumput laut) menjadi salah satu alternative. Pada penelitian ini kami melakukan kombinasi karagenan dengan tepung konjak untuk mendapatkan karakteristik yang lebih baik. Tepung konjak merupakan tanaman iles iles (Amorphophallus) yang banyak mengandung umbi glukoman berupa heteropolisakarida yang terdiri dari β-D-glukosa (G) dan β-D-manosa (M) dengan rasio perbandingan 1:1,6. Tepung konjak dapat berfungsi sebagai bahan pengental, pembentuk gel, dan pengikat air. Tujuan pada penelitian ini yaitu untuk mengetahui  kondisi karakteristik edible film dengan cara mengkombinasikan kandungan antara bahan dasar karagenan dengan tepung konjak  dan mengvariasikan konsentrasi gliserol untuk  mendapatkan tekstur jelly dan karaketristik yang lebih baik. Pada penelitian ini menggunakan 2 parameter yang divariasikan yaitu Kombinasi tepung konjak dan karagenan dengan perbandingan 1: 1, 1: 2 dan 1:3 dan konsentrasi gliserol yaitu 5 %, 10% dan 15 % dengan kondisi yang dikontrol yaitu temperature campuran 85°C, Temperatur pengeringan 50 °C selama  24 jam. Penelitian ini menghasilkan data korelasi yaitu terhadap penambahan tepung konjak menyebabkan kadar air dan daya larut air meningkat serta  laju perpindahan air menurun dan tidak berpengaruh pada ketebalan edible yang terbentuk.  Sedangkan gliserol, semakin rendah konsentrasinya menyebabkan  kadar air rendah, ketebalan edible film menurun, laju perpindahan air semakin naik, serta daya larutnya mengecil.
RELIABLE MARKER OF ATHEROGENICITY IN TYPE 2 DM – A COMPARATIVE STUDY ON GLYCOSYLATION GAP AND HAEMOGLOBIN GLYCATION INDEX.
Authors: S Meera , N Nithya K
Published: October 2020

Background: To prevent acute and chronic complications, monitoring & controlling the level of diabetic indicators become an integral part of diabetic care. Factors that increase or decrease the intracellular glucose level relative to external plasma glucose levels causes the alteration in glycation, which leads to discordance between HbA1C and fructosamine. Aim of the study was to compare the Cardiovascular disease(CVD) risk prediction property of GG(Glycosylation gap) & HGI (Haemoglobin glycation index), 2 statistical measures to assess the disparity between actual HbA1C and the predicted value of HbA1C in Diabetes Mellitus(DM),by correlating them with predictor of atherogenicity and CVD– Atherogenic index of plasma(AIP).

Materials & Method: This Cross sectional study conducted on 142 type 2 DM patients .Blood samples collected to estimate FBS, HbA1c, Fructosamine , Triglyceride &HDL. GG & HGI calculated from predicted HbA1C from fructosamine and Predicted HbA1C from mean blood glucose respectively.

Results: AIP&HGI showed significant correlation compared to GG and AIP. Study concludes the usefulness of HGI in type 2 DM as a regular monitor for CVD risk prediction for improved healthcare.

Keywords: Haemoglobin glycation index ; Glycosylation gap ;Cardiovascular disease.
Függőség és rendészet: addikciók szűrése, kezelése és megelőzése a rendészeti gyakorlatban a tevékenységi alapmodell tükrében
Authors: Erdős Ákos
Published: October 2020

A tanulmány a tevékenységi alapmodellt elméleti keretként felhasználva mutatja be a rendészeti gyakorlatban megjelenő addikciók szűrésére, kezelésére és megelőzésére szolgáló tevékenységeket, módszereket, illetve a külföldi rendészeti szerveknél bevált jó gyakorlatokat. A tanulmányban négy dimenzióban vizsgálom az addikciók szűrésének, megelőzésének és kezelésének lehetőségeit a hazai rendészeti gyakorlatban: az egyén és hatékonyság, az egyén és egészség, az egészség és szervezet, valamint a hatékonyság és szervezet szintjein.
Evaluation of the Educational Drama as an Innovative Method to be Adopted by Teachers in Order to Enhance Critical Thinking Skills of Students in Primary School
Authors: Dima Aikaterini , Kaiafa Eleni , Tsiaras Asterios
Published: October 2020

The aim of this study is to examine and determine the extent to which educational drama, as an innovative teaching approach, can cultivate critical thinking of students in primary school. Based on the principles of educational drama, 15 theatrical workshops were designed in relation with and corresponding to the culture and interests of the specific age group. The experimental method that was followed, was designed and implemented in three discrete stages including: the pre-research stage, the main research stage and the results extraction stage. The sample comprising 400 students aged 8-10 has been drawn from six different primary schools in Greece, the subjects of which were randomly selected. Five critical thinking skills were studied, including subtraction, induction, observation, reliability, detection and troubleshooting skills. The qualitative and quantitative data collected was next triangulated in order to lead to the desired result. The results confirmed the main research hypothesis, hence educational drama, as an innovative method, can enhance students' critical thinking in primary school.
Time-resolved and Temperature-dependent Broadband Emission of Plasmon-coupled Quantum Dots
Authors: Rice Quinton , Raut Sangram , Chib Raul , Gryczynski Zygmunt , Gryczynski Ignacy , Wang Andrew , Yu Willliam Y. , Tabibi Bagher , Seo Felix Jaetae
Published: October 2020

The broadband photoluminescence (PL) emissions from CdSe QDs and plasmon-coupled QDs were characterized with time-resolved and temperature-dependent spectroscopy for the application of solid-state white light. The origin of broad spectral emission includes the transitions from bandedge and surface-trapped states. The emission intensity enhancement of plasmon-coupled QDs with respect to that of bare QDs is attributable to the reduction of nonradiative decay and the local field enhancement with plasmon-exciton coupling through the Coulomb interaction. The temperature-dependent and time-resolved PL spectroscopy revealed the existence of selective contribution strength of both the local field enhancement and the reduction of nonradiative decay with plasmon-exciton coupling at different spectral regions.
Optimal Portfolio Insurance under Nonlinear Transaction Costs
Authors: Katsikis Vasilios N. , Mourtas Spyridon D.
Published: October 2020

The minimization of the costs related to portfolio insurance is a very important investment strategy. In this article, by adding the transaction costs to the classical minimum cost portfolio insurance (MCPI) problem, we define and study the MCPI under transaction costs (MCPITC) problem as a nonlinear programming (NLP) problem. In this way, the MCPI problem becomes more realistic. Since such NLP problems are commonly solved by heuristics, we use the Beetle Antennae Search (BAS) algorithm to provide a solution to the MCPITC problem. Numerical experiments and computer simulations in real-world data sets confirm that our approach is an excellent alternative to other evolutionary computation algorithms.
Evaluation of hepatotoxicity in elderly with HIV/AIDS using isoniazid
Authors: Santana Claudinei Alves , Santos Gustavo Alves Andrade dos
Published: October 2020

Introduction: The aging of the population becomes notorious from the twentieth century reaching several countries of the world. Data from the 2019 Epidemiological Bulletin of the Ministry of Health report an increase in the incidence of AIDS among elderly males in the period 2008 to 2018 of 9.7% and a 5% reduction among women. The impairment of the immune system favors the emergence of diseases considered opportunistic and Tuberculosis (TB) is the leading cause of death among individuals with AIDS. One of the measures to prevent TB/HIV co-infection in young and elderly adults, according to the World Health Organization, is treatment with the drug isoniazid, which aims to reduce the risk of illness from Mycobacterium tuberculosis and consequently the manifestation of TB. Regarding isoniazid, hepatotoxicity is a potentially serious adverse reaction that can even result in death. Objective: To evaluate the risk of hepatotoxicity to the use of isoniazid measured through laboratory test results through liver enzymes. METHOD: Descriptive and analytical retrospective cross-sectional study with elderly patients with HIV/AIDS using isoniazid in a specialized HIV/AIDS Service from 2008 to 2011. Laboratory results of hepatic transaminases (AST and ALT) and glutaryltranferase range from a secondary database at 3 specific moments (pre-treatment, concomitant treatment and post-treatment with isoniazid) and subjects’ characteristics (age, gender, time of HIV infection) were analyzed. The data were analyzed in statistical program SPSS 20. Result: We analyzed 12 subjects aged 60 years or older, 75% (9) men, mean age 63 years and 25% (3) women, mean age 68 years. The subjects had an average of 15 years of HIV infection. There was an increase of 20.9% in AST, and 11.5% in the Range Gutamiltransferase concomitant with the treatment in relation to the pre-treatment values. Conclusion: Laboratory results for the use of isoniazid showed a slight hepatotoxicity elevation without the need to discontinuation of preventive treatment with isoniazid, however, follow-up by a multidisciplinary and pharmaceutical team is necessary.
Development of mobile application for safe surgery checklist
Authors: Silva Rafael Henrique , Gatti Marcia Aparecida Nuevo , Marta Sara Nader , Caram Nirave Reigota , Franzolin Solange de Oliveira Braga , Pedro Ketilin Mayra , Lopes Jaqueline de Souza
Published: October 2020

Communication and information technologies are increasingly influencing health actions, as well as patient safety. Thus, this study aimed to develop an application for conference and control of all stages of the Safe Surgery checklist suggested by the World Health Organization improving the safety of patients submitted to surgery. The problem of research lies precisely in the absence of mobile applications capable of meeting the need for patient safety. This study is applied in the technological development of an application with the possibility of deployment in any health service and easy installation on mobile devices. The app was built based on the Safe Surgery checklist established by the World Health Organization. The application allows patient identification through three identifiers. Later it contemplates all the items of the three stages of the checklist of safe surgery: Before anesthetic induction, Before the Surgical Incision and Before the Patient Leaves the Room. At the end of all the steps of the application, it calculates the risk to patient safety. The application developed is a tool that can be implemented in health institutions and used by professionals working in the operating room.
Desenvolvimento de aplicativo móvel para checklist de cirurgia segura
Authors: Silva Rafael Henrique , Gatti Marcia Aparecida Nuevo , Marta Sara Nader , Caram Nirave Reigota , Franzolin Solange de Oliveira Braga , Pedro Ketilin Mayra , Lopes Jaqueline de Souza
Published: October 2020

As tecnologias de comunicação e informação estão influenciando de forma crescente as ações na área da saúde, assim como a segurança do paciente. Desta forma, este trabalho teve como objetivo desenvolver um aplicativo para conferência e controle de todas as etapas do checklist de Cirurgia Segura sugerido pela Organização Mundial da Saúde melhorando a segurança do paciente submetido à cirurgia. O problema da pesquisa está justamente na ausência de aplicativos para dispositivos móveis capaz de atender a necessidade de segurança do paciente. Trata-se de estudo aplicado no desenvolvimento tecnológico de um aplicativo com possibilidade de implantação em qualquer serviço de saúde e de fácil instalação em dispositivos móveis. O aplicativo foi construído baseado no checklist de Cirurgia Segura estabelecido pela Organização Mundial da Saúde. O aplicativo permite a identificação do paciente através de três identificadores. Posteriormente contempla todos os itens das três etapas do checklist de cirurgia segura: Antes da Indução Anestésica, Antes da Incisão Cirúrgica e Antes do Paciente Sair da Sala. Ao final de todos as etapas do aplicativo, ele calcula o risco para a segurança do paciente. O aplicativo desenvolvido é uma ferramenta que pode ser implantada nas instituições de saúde e utilizada pelos profissionais que atuam no centro cirúrgico.
Pelatihan Manajemen Bersosial Media Dalam Strategi Pemasaran Paguyuban Jip4x4 Bromo Tengger Semeru Kabupaten Malang
Authors: Dura Justita , Puspa Dewi Mariana , Mariesti Andriany Lussia , Cahyaningtyas Fadilla , Mulyaningtyas Mulyaningtyas
Published: October 2020

Paguyuban Jip Bromo Tengger Semeru merupakan salah satu UMKM yang terletak di Jawa Timur dengan usaha transportasi ke Bromo Semeru. UMKM ini merupakan usaha yang berbeda dengan lainnya, di mana tujuannya adalah untuk meningkatkan kesejahteraan bersama. Untuk itu, pengelolaan pemasaran paguyuban Jip harus dapat dilakukan secara produktif, efektif, dan efisien. Untuk mencapai kemampuan pengelolaan tersebut, umkm ini harus dapat berusaha secara luwes sehingga mampu bersaing dengan pelaku ekonomi lainnya dalam menjalakan usahanya. Salah satunya disebabkan kurang professionalnya pengurus dalam mengelola usahanya. Oleh karena itu, paguyuban Jip ini harusnya mampu meningkatkan kualitas pengelolaan pemasaran dalam bersosial media. Tujuan dalam pelatihan adalah para pengurus dan anggota paguyuban bisa mengelola social media dengan baik dalam melakukan pemasaran jasa. Metode pengabdian yang digunakan dengan melalui pelatihan dengan metode presentasi, Tanya jawab, dan praktik. Dengan adanya pelatihan manajemen bersosial media ini, tingkat pemasaran para driver jip bromo tengger semeru diharapkan bisa meningkat.