bluuebunny/crossref_metadata_2025 huggingface dataset:
La Teoría de la Interpretación de la Ley a comienzos del siglo XX [1.2885]
Authors: Tijmes Jaime
Published: September 2022

¿Cómo y por qué cambió la teoría de la interpretación de la ley a principios del siglo XX? ¿Cómo evolucionaron en esa época los conceptos fundamentales de la teoría de la interpretación jurídica y cuál fue su contexto teórico jurídico? Sostengo que las dos innovaciones más importantes de la teoría de la interpretación de la época de 1900, vale decir, la ampliación del ámbito de las lagunas y la escisión de la doctrina de la interpretación, solo se pueden explicar de un modo histórico. Se fundan, en primer lugar, en la evolución desde el idealismo de la época del derecho natural y de la escuela histórica, hacia el voluntarismo de principios del siglo XX. En segundo lugar, se fundan en el desarrollo de distintas variantes del voluntarismo.
Projeto “não é só uma brincadeirinha!” Cyberbullying têm consequências sim! Cyberbullying no ambiente escolar: consequências e intervenção
Authors: Sá Bruna de , Stahl Josiane Cristina Rabac , Anjos Maiara Veronica Piroski dos , Lara Sarah Rodrigues de
Published: September 2022

A prática do cyberbullying aumentou consideravelmente com uso frequente das tecnologias e de redes sociais diante do cenário de pandemia da COVID-19, no qual a maioria das atividades escolares são realizadas de maneira remota. Sendo assim, o artigo tem intuito de compreender os efeitos do cyberbullying no contexto escolar, apresentando aos educandos como a prática do cyberbullying acontece, trazendo a reflexão das consequências dessa prática para alunos do 4° ano de uma escola privada do município de Curitiba. Além disso, o presente artigo aborda as características, consequências e formas de intervenção ao cyberbullying no âmbito escolar, bem como uma entrevista realizada em uma escola de Curitiba, investigando a existência desta prática na instituição. Além disso, foi desenvolvido um projeto com os alunos da respectiva escola, a fim de demonstrar os efeitos da violência cibernética no indivíduo. Ademais, são apresentadas, por meio de uma pesquisa bibliográfica descritiva, síndromes e transtornos que podem surgir com a ação do que muitas vezes é intitulado e considerado apenas como uma “brincadeirinha”, desmistificando este conceito, abordando o significado de uma prática que resulta em consequências, como emoções negativas e aspectos depressivos.
Dignidade no cárcere: relato de experiência sobre a atuação do Conselho da Comunidade Carcerária em Juazeiro do Norte - CE
Authors: Gouveia Alania Maria Leal , Barbosa Wendell de Freitas
Published: September 2022

A presente pesquisa versa sobre um relato de experiência de residência social na Vara de Execuções Penais de Juazeiro do Norte-CE com foco na atuação do Conselho da Comunidade Carcerária do município, órgão recém-instalado por esta Secretaria de Vara, com a finalidade de prestar assistência aos encarcerados, aos egressos e aos familiares do sistema prisional. Tendo em vista as violações que atentam à dignidade dos presos como a superlotação, as condições insalubres no cárcere e a carência assistencial, urge a necessidade de se conhecer ações realizadas em prol dos internos no município, com a instalação do Conselho da Comunidade. Portanto, objetiva-se conhecer as ações realizadas pelo referido órgão no intuito de explorar o que se realiza na defesa dos direitos humanos da população carcerária em análise. A pesquisa é de cunho exploratório, sendo, predominantemente de caráter qualitativo e se utiliza de dados do Relatório da Secretaria de Segurança Pública (2020), de legislações como a Constituição Federal, o Código Penal e a Lei de Execuções Penais (LEP), além de materiais bibliográficos conceituados de autores como Goffman (1975) e Capez (2012). Ao longo da pesquisa, destacam-se as ações propostas pelo Conselho, bem como o estudo das legislações que regem o tema, o acompanhamento da demanda das execuções penais e uma reflexão sobre a importância da integração de outros órgãos junto ao Conselho da Comunidade.
Faktor-Faktor Yang Mempengaruhi Perusaiiaan Melakukan Right Issue Di Bursa Efek Indonesia
Authors: Hatta Zakaria
Published: September 2022

Right Issue merupakan cara yang disukai emiten dalam menghimpun dana, karena Right Issue memberikan kesempatan bagi pemilik saham lama untuk mempertahankan proporsi saham mereka. Penerbitan Right Issue biasanya ditujukan untuk memperoleh dana tambahan dari investor atau masyarakat baik untuk kepentingan pembayaran utang, ekspansi usaha, dan lainnya. Kebijakan perusahaan melakukan Right Issue merupakan upaya untuk menghemat biaya emisi serta menambah jumlah saham, beredar. Dari sisi emiten, Right Issue merupakan upaya penambahan modal dengan biaya yang lebih murah dibandingkan dengan IPO (Initial Publik Offering) sebab Right Issue tidak memerlukan banyak jasa, seperti penjamin emisi, penilai, konsultan hukum dan jasa lainnya. Secara teoritis, terdapat 7 (tujuh) alasan (motif) perusahaan melakukan right issue yakni : untuk ekspansi usaha melalui merger, akuisisi, take over, dan leverage buyout, untuk membayar kewajiban jatuh tempo, untuk meningkatkan likuiditas saham, untuk restrukturisasi, untuk modal kerja, untuk meningkatkan jumlah saham beredar, dan untuk meningkatkan porsi kepemilikan saham. Dengan melakukan pengamatan terhadap 70 (tujuh puluh) perusahaan yang melakukan right issue pada tahun 2010-2015, hasil penelitian menunjukkan bahwa hanya 5 (lima) motif perusahaan melakukan right issue yakni: untuk ekspansi usaha, restrukturisasi, modal kerja, bayar kewajiban jatuh tempo, dan meningkatkan jumlah saham beredar. Selain itu, diperoleh motif baru dalam melakukan right issue di Indonesia yakni: untuk penyaluran kredit korporasi pada sektor perbankan.
Pengaruh Kompensasi Finansial terhadap Kepuasan Kerja Karyawan Pada PT. Mandala Multifinance, Tbk di Kota Makassar
Authors: Perwira Iwan
Published: September 2022

Penelitian ini dilaksanakan bulan Juli sampai Agustus 2015 pada PT. Mandala Multi Finance, Tbk Kota Makassar. Tujuan penelitian untuk mengetahui pengaruh pemberian kompensasi terhadap kepuasan kerja karyawan pada PT. Mandala Multi Finance, Tbk Kota Makassar. Responden berjumlah 50 orang. Metode yang digunakan yakni menyebarkan kuesioner lalu kemudian di olah menggunakan program SPSS 18 for windows. Hasil penelitian menunjukkan bahwa secara simultan kompensasi finansial dan kompensasi non finansial berpengaruh signifikan (nyata) terhadap kepuasan kerja karyawan PT. Mandala Multifinance, Tbk di Kota Makassar. Secara parsial kompensasi finansial lebih berpengaruh secara signifikan dibanding kompensasi non finansial.
PENGARUH SISTEM INTERNAL KONTROL , KOMPETENSI MANAJERIAL TERHADAP TATA KELOLA DAN KINERJA PERBANKAN PROVINSI SULAWESI SELATAN
Authors: Dahyar Nirwan
Published: September 2022

Tujuan penelitian ini untuk menganalisis pengaruh sistem internal kontrol terhadap tata kelola, pengaruh kompetensi manajerial terhadap tata kelola, pengaruh sistem internal kontrol melalui tata kelola terhadap kinerja perbankan, pengaruh kompetensi manajerial melalui tata kelola terhadap kinerja perbankan dan pengaruh tata kelola terhadap kinerja perbankan di Provinsi Sulawesi Selatan.

Penelitian dilaksanakan pada Perbankan di Provinsi Sulawesi Selatan dengan populasi yaitu manajer bagian audit dan keuangan sebanyak 648 orang dan sampel sebanyak 247 responden berdasarkan rumus Slovin. Data hasil kuesioner dianalisis menggunakan Structural Equation Model menggunakan bantuan AMOS 18.

Hasil penelitian menemukan sistem internal kontrol secara langsung berpengaruh positif dan tidak signifikan terhadap kinerja perbankan. Berarti sistem  internal kontrol sudah diterapkan, namun belum mampu mencapai hasil yang sesuai input, process, output, outcome, benefit dan impact sebagai penilaian kinerja perbankan. Sistem kontrol internal secara tidak langsung berpengaruh negatif dan tidak signifikan terhadap kinerja perbankan melalui tata kelola. Berarti perlu perbaikan dalam sistem pengendalian internal organisasi yang sesuai dengan prinsip ketatalaksanaan bidang keuangan untuk meningkatkan kinerja perbankan. Kompetensi manajerial secara langsung berpengaruh dominan positif dan signifikan terhadap kinerja perbankan. Berarti kompetensi manajerial yang dimiliki pegawai sudah baik dan mendukung pencapaian hasil kerja di bidang keuangan yang sesuai input, process, output, outcome, benefit dan impact sebagai penilaian kinerja perbankan serta menjalankan prinsip ketatalaksanaan di bidang perbankan.
Analisis Kinerja Karyawan Sebelum dan Sesudah Reimplementasi System Application and Product pada Unit Bisnis Sera Group Makassar
Authors: Kartini  , Anshar Muh. Ashary
Published: September 2022

Penelitian ini bertujuan untuk menganalisis kinerja karyawan sebelum dan sesudah penerapan reimplementasi system application and product pada unit bisnis Sera Group Makassar. Jenis penelitian ini adalah pendekatan kualitatif dengan metode penelitian menggunakan teknik fenomenologi. Hasil penelitian menunjukkan bahwa berdasarkan hasil wawancara bahwa kinerja karyawan dengan  indikator kualitas, ketepatan waktu dan kemandirian sudah membaik setelah adanya reimplementasi SAP pada unit bisnis Sera Group Makassar.
Pengaruh Inflasi Dan Jumlah Uang Beredar Terhadap Penentuan Suku Bunga Sertifikat Bank Indonesia (SBI)
Authors: Dauda Paris
Published: September 2022

Penelitian ini bertujuan untuk mengetahui Pengaruh Inflasi dan Jumlah Uang Beredar Terhadap Penentuan Suku Bunga Sertifikat Bank Indonesia (SBI). Dalam penelitian ini dianalisis mengenai pengaruh variabel-variabel ekonomi makro (Jumlah Uang Beredar dan Inflasi) terhadap penentuan kebijakan suku bunga SBI. Dengan didukung oleh beberapa teori tentang Suku Bunga, SBI, Jumlah Uang Beredar dan Inflasi, maka penelitian ini dapat dilakukan untuk melihat berbagai pengaruh variabel-variabel tersebut. Metode yang digunakan adalah analisis regresi linear berganda. Hasil penelitian yang diperoleh, variabel Inflasi dan Jumlah Uang Beredar berpengaruh positif terhadap suku bunga SBI, sementara itu pengujian hipotesis menunjukkan bahwa: 1) variable inflasi berpengaruh positif tidak signifikan. 2) variable jumlah uang beredar berpengaruh positif signifikan
Analisis Saham Perusahaan Badan Usaha Milik Negara yang Listing di Bursa Efek Indonesia
Authors: Muspa Muspa
Published: September 2022

Tujuan penelitian ini adalah untuk menganalisis harga saham dengan membandingkan nilai intrinsik dengan harga pasar saham dari masing-masing saham perusahaan Badan Usaha Milik Negara untuk membantu investor dalam pengambilan keputusan berivestasi. Adapun metode analisis yang digunakan adalah analisis deskriptif kuantitatif menggunakan analisis fundamental dengan metode Price Earning Ratio (PER). Hasil analisis menunjukkan bahwa ADHI, WIKA, PTPP dan JSMR berada pada kondisi undervalued, keputusan yang dapat diambil adalah membeli atau menahan saham tersebut. Kelima saham lainnya yaitu BBRI, BBTN, BMRI, PTBA dan TINS berada pada kondisi overvalued, keputusan yang dapat diambil adalah menjual saham tersebut.
Penerapan Teknik Motion Graphic pada Karya Air Magazine "Zero Waste is the New Taste"
Authors: Efiyanti Bella Meillenia , Astuti Aprilina Dwi
Published: September 2022

Karya Air Magazine “Zero Waste is The New Taste” merupakan karya produksi audio visual yang membahas mengenai  gaya hidup zero waste atau bebas sampah. Banyak faktor yang mendukung  pembuatan sebuah produksi  supaya  menarik  minat penonton. Diantaranya adalah penerapan motion graphic yang dapat mewarnai sebuah karya produksi sehingga menghasilkan visual yang informatif, khas, dan memiliki nilai estetika. Motion graphic juga dapat memperjelas informasi yang disampaikan kepada penonton. Tujuan dari penciptaan karya ini adalah menerapkan motion graphic pada  program produksi audio visual dengan format air magazine berjudul “Zero Waste is The New Taste”. Metode penciptaan karya dilakukan melalui tiga tahap yaitu tahap pra produksi, produksi dan paska produksi. Teknik motion graphic yang diimplementasikan pada pembuatan karya ini adalah teknik animation graphic ,motion tracking dan teknik motion graphic compositing. Hasil dari karya produksi ini merupakan animation graphic menciptakan pergerakan gambar yang dinamis dan estetik diterapkan menggunakan transform tools seperti size dan position Untuk membuat looks stop-motion dapat digunakan effects posterize time dan toggle hold keyframe, lalu menggunakan keyframe assistant easy ease untuk membuat looks yang dinamis. Teknik motion tracking diterapkan dengan menggunakan tools Tracker pada footage vid
Cover Depan dan Belakang
Authors: Multimedia & Komunikasi Jurnal Ilmiah
Published: September 2022

Cover Depan dan Belakang
Cover Dalam - Daftar Isi
Authors: Multimedia & Komunikasi Jurnal Ilmiah
Published: September 2022

Cover Dalam - Daftar Isi
Accuracy of Revised Tokuhashi Scoring System and Prognostic Factors to Predict Life Expectancy in Lung Cancer Patients with Spinal Metastasis
Authors: Choovongkomol, MD Kongtush , Sirisopikun, MD Veerapat , Piyapromdee, MD Urawit , Tanaviriyachai, MD Terdpong , Jongkittanakul, MD Sarut
Published: September 2022

Purpose: This study aimed to verify the accuracy of the revised Tokuhashi scoring system to identify the prognosis and life expectancy of lung cancer patients with spinal metastasis. We also aimed to find the factors that were related to the prognosis and actual death.
Method: Lung cancer patients with spinal metastasis who were diagnosed between January 2014 to December 2018 were included in this study. Demographic data, radiographic data, revised Tokuhashi score parameters, actual death, and treatment administered were collected from the hospital tumor database. The relationship between each parameter and actual death were collected and multivariable logistic regression analysis was used to explore the associated factors.
Results: Totally 181 patients were included in this study. The accuracy of the revised Tokuhashi scoring system in this study was 80.68% for scores 0-8 and 100% for scores ≥ 9. Sensitivity and specificity were 100%and 80.7%, respectively, for the prediction of life expectancy ≥ 6 months. LR+ was 5.18. Female (HR=0.58, P=0.001), good general condition (HR=0.34, P=0.036), none of extra spinal foci metastasis (HR=0.40, P=0.002), 1 or 2 extra spinal foci metastasis (HR=0.54, P=0.003), radiation (HR=0.57, P=0.02), and chemotherapy (HR=0.51, P=0.004) were the associated factors with statistical significance.
Conclusion: The revised Tokuhashi scoring system for lung cancer with spinal metastasis had satisfactory accuracy rate to predict life expectancy, especially for > 6 months (score ≥ 9). We also found that females, good general condition, number of extra spinal foci < 3, radiation, and chemotherapy were significantly good prognoses for life expectancy.
Effects of substitution of soybean meal with rapeseed meal and glutamine supplementation on growth performance, intestinal morphology, and intestinal mucosa barrier of Qiandongnan Xiaoxiang Chicken
Authors: Zhang Bolin , Liu Ning , Hao Meilin , Xie Yuxiao , Song Peiyong
Published: September 2022

Objective: The present study was to evaluate the effects of different rapeseed meal substitution (RSM) and glutamine (Gln) supplementation on growth performance, intestine morphology, and intestinal mucosa barrier of broilers.Methods: Four hundred and twenty Qiandongnan Xiaoxiang Chicken at 1 day of age with similar weight were chosen and were randomly assigned into 7 groups, consisting of 10 replicates per group and 6 broilers per replicate. Three groups were provided with diets separately containing 0%, 10%, and 20% RSM, and the other four groups were fed with diets separately supplemented with 0.5% and 1% Gln based on the inclusion of 10% and 20% RSM. At 21 and 42 days of age, 10 broilers per group were chosen to collect plasma and intestinal samples for further analysis.Results: The results showed that 10% RSM decreased average daily feed intake (ADFI) and average daily weight gain (ADG) of broilers at 21 days of age (p<0.05). Furthermore, both ADFI and ADG of broilers at 21 and 42 days of age were decreased by 20% RSM, while feed conversion ratio (FCR) was increased (p<0.05). Besides, 10% RSM resulted in lower intestinal villus height and the ratio of villus height to crypt depth, deeper crypt depth (p<0.05), combined with the lower mRNA expressions of occludin, claudin-1, and zonula occludens-1 (ZO-1) in broilers at 21 days of age (p<0.05). Similar results were also observed in broilers at 21 and 42 days of age fed with 20% RSM. However, 1% Gln improved the growth performance of broilers fed with 10% and 20% RSM (p<0.05), ameliorated intestine morphology and elevated mRNA expressions of occludin, claudin-1 and ZO-1 (p<0.05).Conclusion: In conclusion, the increasing inclusion of RSM resulted in more serious effects on broilers, however, 1.0% Gln could reverse the negative effects induced by the inclusion of RSM.
Biosimilars open up new opportunities in chronic diseases
Authors: Brandi Maria Luisa
Published: September 2022

The World Health Organization defines a biosimilar product as a biotherapeutic that is similar in terms of quality, safety and efficacy to an already licensed reference product available on the market. To ensure similar efficacy and safety, comparability studies for biosimilars should be carried out at quality, preclinical and clinical level. In this article we provide an overview of biosimilars, looking at the definition of the term biosimilar, the regulatory framework and the future prospects for these drugs. As biosimilar drugs will revolutionize the treatment of osteoporosis, this paper aims to evaluate the pros and cons of choosing the teriparatide biosimilar Movymia®, looking at whether it really can be considered clinically equivalent to the original drug. The benefits of biosimilars may include improving patient access and affordability. Off-patent biologics and biosimilars may also create market competition and stimulate incremental innovation by manufacturers.
Die Methodenwahl zur Ermittlung einer angemessenen Barabfindung nach dem AktG
Authors: Grunert Mirko
Published: September 2022

Using an interdisciplinary approach, this thesis examines the choice of the correct company valuation method in cash compensation cases under stock corporation law. In addition to the economic status quo, the legal requirements and current case law are analyzed in detail. The stock market price is discussed not only as a minimum price, but also as an approximation of the enterprise value. The comparative legal view of the USA reveals significant differences in the legal and economic spheres. As a result, the author argues for a more quantitative approach in the choice of method, since no method is currently qualitatively superior.
Jahrbuch Nachhaltigkeit 2019
Authors:   metropolitan Fachredaktion
Published: September 2022

Verbraucher, Kunden und Geschäftspartner messen Unternehmen zunehmend daran, wie sie die Ziele einer nachhaltigen Entwicklung verfolgen: Welchen Mehrwert liefert ein Betrieb in der Region, ist er sozial engagiert, wie klimaschädlich ist die Produktion, werden Ressourcen verschwendet, wie transparent ist die Kette der Zulieferer oder wie verantwortungsvoll ist der Umgang mit Mitarbeitern?

Das Jahrbuch Nachhaltigkeit 2019 bietet aktuelle Informationen, Orientierung und wertvolle Impulse für den Einstieg in das betriebliche Nachhaltigkeitsmanagement.

Beiträge über Aspekte und neue Entwicklungen wie Digitalisierung und Nachhaltigkeit, Arbeit 4.0, Elektromobilität

Best-Practice-Beispiele aus Unternehmen

relevante Initiativen, Organisationen und hilfreiche Netzwerke

eine Übersicht über Messen und Termine

wichtige Wettbewerbe und sinnvolle Zertifikate
Macht macht sexy
Authors: Orszulik Carola
Published: September 2022

Macht ist die Fähigkeit, etwas zu bewirken

In unserer Gesellschaft, in Unternehmen, im Sport und auch im kulturellen Bereich werden Menschen gebraucht, die ihre Macht bewusst, zielgerichtet und sinnstiftend einsetzen. Macht zu übernehmen heißt, Verantwortung zu übernehmen. Doch nicht die Position verleiht langfristig Einfluss und Ausstrahlung, vielmehr kommt es auf die innere Stärke und Einstellung an.

Jeder Mensch besitzt das Potenzial, sein Leben eigenverantwortlich zu gestalten und nach außen zu wirken. Carola Orszulik definiert mit dem Excalibur-Prinzip fünf Ansatzpunkte, um dieses Potenzial zu entfesseln: Ethos, Empathie, Entscheidungsfähigkeit, Eingebungskraft und Energie. Diese Elemente können trainiert und wie ein Schwert geschärft werden, um dem Träger Macht und Freiheit zu verleihen.
7 Geheimnisse erfolgreicher Unternehmer
Authors: Bobach Lars
Published: September 2022

Die wichtigsten Selbstmanagement-Tools und -Tricks für Ihr Business

Unternehmer, Selbstständige und Führungskräfte leben in einer verrückten Zeit. Dank der Digitalisierung verschwimmen Arbeits- und Berufsleben zunehmend. Arbeit ist immer und vor allen Dingen überall. Höchste Zeit, sich und sein Unternehmen mit den passenden Werkzeugen neu aufzustellen.

In diesem Buch verrät der erfolgreiche Unternehmer Lars Bobach unter anderem, warum Sie …

interne E-Mails in Ihrem Team komplett verbieten sollten.

keine Aufgabenliste führen sollten.

unbedingt Papier und Stift nutzen sollten.

Außerdem zeigt er Ihnen, wie Sie …

Ihre E-Mail-Flut drastisch reduzieren.

eine sinnvolle und zeitgemäße digitale Ablage organisieren.

Ihr Unternehmen und Ihr Privatleben papierminimiert gestalten.

sich mit positiven Gedanken auf Erfolg trimmen.

den Kalender als das wichtigste Selbstmanagement-Tool einsetzen.

den Überblick über Ihr Leben – privat und beruflich – zurückgewinnen.

Die richtigen Tools und Tricks unterstützen Sie dabei, dem Hochgeschwindigkeitsalltag zu entfliehen und sich und Ihr Business auf Erfolgskurs zu lenken, denn: Der Schlüssel zu einem glücklichen und erfolgreichen Leben ist ein gutes Selbstmanagement!
Wo sehen Sie Ihre größten Schwächen?
Authors: Krahl Stefanie
Published: September 2022

Auf alle Fragen perfekt vorbereitet

Mit 24 Lernkarten zum Herausnehmen

Wer hat keine Angst vor der ungeliebten Frage nach den Stärken und Schwächen? Diese und andere Herausforderungen gilt es im Vorstellungsgespräch zu meistern. Ob Informationsfragen, Situationsfragen oder Stressfragen, die Karriereberaterin Stefanie Krahl zeigt Ihnen mit zahlreichen Antwortmöglichkeiten, wie Sie souverän reagieren und sich geschickt positionieren.

Das Trainingsbuch Wo sehen Sie Ihre größten Schwächen? und die heraustrennbaren Lernkarten bieten praktische Tipps und viel Platz für Ihre individuellen Antworten. So können Sie sich zielgerichtet und effizient auf das Jobinterview vorbereiten und der Frage nach Ihren Schwächen gelassen entgegensehen.
Investigation of the Global Trend of Thyroid Cancer Incidence and Its Relationship with the Prevalence of Type 2 Diabetes: An Application of Longitudinal Random Effects Regression Model
Authors: Rezaei Gazaki Maryam , Askari Shahi Mohsen , Malboosbaf Ramin , Jambarsang Sara
Published: September 2022

Background: In recent years, the incidence of thyroid cancer has been increasing. On the other hand, those with insulin resistance often have higher thyroid volume and a risk of developing thyroid nodules. Objectives: The objective of this study was to investigate the global trend of thyroid cancer and its relationship with the prevalence of type 2 diabetes. Methods: The information in the present study is related to the prevalence of type 2 diabetes and the incidence of thyroid cancer in all countries of the world, which was extracted from the Global Burden of Disease site during 1990 - 2019. In order to investigate the relationship between the prevalence of type 2 diabetes and the incidence of thyroid cancer, a longitudinal random effects regression model was used with both random effects of intercept and the slope of the regression line. Results: The results showed that the risk of developing thyroid cancer associated with diabetes was 0.00024 (95% CI 0.00023 - 0.00025), 24 persons per 100000. This significance level was also evaluated separately in men and women, so that the relative risk in men was estimated to be 0.00018 (95% CI 0.00017 - 0.00019) and in women equal to 0.00033 (95% CI 0.00031 - 0.00035). Conclusions: Findings showed that type 2 diabetes can be a risk factor for thyroid cancer. So that this effect can be considered on both men and women and is more intense in women than men.
Benchmarking Machine Learning Algorithms for Diagnosis of Renal Cell Carcinoma
Authors: Dai Tao , Zhu Shuai , Han Fuchang , Ye Mingji , Xiang Wang , Tan Weili , Pei Xiaming , Liao Shenghui , Xie Yu
Published: September 2022

Background: Accurate differentiation of angiomyolipoma (AML) from renal cell carcinoma (RCC) is important in RCC diagnosis. Objectives: This study aimed to evaluate the performance of different supervised machine learning (ML) algorithms for RCC based on computed tomography (CT) examinations. Patients and Methods: The CT images of known cases of RCC or renal AML were collected and divided into training and testing groups. The texture features of CT images were drawn and quantified in MaZda software; a total of 352 features were drawn from each image. Top 10 features with statistical significance for differentiation of RCC from benign tumors in the training group were selected to establish diagnosis models based on 16 supervised ML algorithms. Next, the models were compared regarding accuracy and specificity. The trained models were further examined by comparison with data from the testing group. Results: Among 16 classifiers trained in this study, the logistic regression, linear discriminant analysis, k-nearest neighbor algorithm, support vector machines (SVMs), ridge classifier, AdaBoost classifier, gradient boosting classifier, and CatBoost classifier showed good performance in discriminating RCC from AML (accuracy, ≥ 0.7; area under the [receiver operating characteristic [ROC]] curve [AUC] ≥ 0.75) in both training and testing datasets. Conclusion: Based on the ML algorithms for big data, diagnostic classifiers can be valuable tools for an accurate diagnosis of RCC. By comparing different algorithms, the present results indicated potential algorithms for the development of RCC diagnostic classifiers.
Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats
Authors: Shekarriz Hekmat , Galedari Mohammad , Nikbakht Masoud , Khorsandi Layasadat
Published: September 2022

Background: Doxorubicin (DOX) is widely used to treat various cancers, but its cardio-toxicity restricts its therapeutic application. Objectives: This study aimed to investigate the effect of 8 weeks of continuous aerobic training (CAT) and administration of crocin (Cr) on the apoptotic index and the expression of Bax and Bcl-2 genes on the DOX-induced cardio-toxicity of rats. Methods: In this experimental study, 50 male Wistar rats were randomly divided into 5 groups, including control, DOX, DOX + CAT, DOX + Cr, and DOX + CAT + Cr groups. Continuous aerobic training consisted of 60 minutes of running with the intensity of 40% - 60% of maximum speed (5 days/week). Apoptotic index and the expression levels of Bax and Bcl-2 genes were determined in the heart tissue. Results: Doxorubicin significantly increased Bax gene expression in the heart tissue of animals (P < 0.001). In contrast, Bcl-2 gene expression significantly decreased (P < 0.001). In all experimental groups, the Bax/Bcl-2 ratio and the percentage of the terminal deoxynucleotidal transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells were significantly diminished compared to the DOX-intoxicated animals. Among experimental groups, CAT had more antiapoptotic effects against DOX-induced cardiac toxicity. Conclusions: Continuous aerobic training and Cr, alone or in combination, could attenuate DOX-induced cardiotoxicity by suppressing apoptosis in the rats.
A Review on Herbal Secondary Metabolites Against COVID-19 Focusing on the Genetic Variants of SARS-CoV-2
Authors: Mohammadi Mohsen , Yahyapour Yousef , Nasrollahian Sina , Tayefeh-Arbab Mohammad Hossein , Javanian Mostafa , Rajabi Fadardi Mohammad , Mousavi Kani Seyedeh Nasim , Honarvar Bakeshloo Parisa , Saghebi Roshanak , Rajabnia Mehdi , Halaji Mehrdad , Pournajaf Abazar
Published: September 2022

Context: An outbreak of the new coronavirus disease 2019 (COVID-19) was reported in Wuhan, China, in December 2019, subsequently affecting countries worldwide and causing a pandemic. Although several vaccines, such as mRNA vaccines, inactivated vaccines, and adenovirus vaccines, have been licensed in several countries, the danger of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants persists. To date, Alpha (B.1.1.7), Beta (B.1.351, B.1.351.2, B.1.351.3), Delta (B.1.617.2, AY.1, AY.2, AY. 3), Gamma (P.1, P.1.1, P.1.2), and Iota (B.1 .526) circulating in the United States, Kappa (B.1.617.1) in India, Lambda (C.37) in Peru and Mu (B.1.621) in Colombia are considered the variants of concern and interest. Evidence Acquisition: Data were collected through the end of August 2021 by searching PubMed, Scopus, and Google Scholar databases. There were findings from in silico, in vitro cell-based, and non-cell-based investigations. Results: The potential and safety profile of herbal medicines need clarification to scientifically support future recommendations regarding the benefits and risks of their use. Conclusions: Current research results on natural products against SARS-CoV-2 and variants are discussed, and their specific molecular targets and possible mechanisms of action are summarized.
Evaluation of Interleukin 2, Interleukin 10, and Interferon Gamma Among Pregnant Women Co-infected With HIV and Plasmodium falciparum
Authors: Akinbo Frederick O. , Abiodun Florence Oluyemi , Omoregie Richard , Omoruyi Zainab , Oriakhi Mathew O.
Published: September 2022

Background: In pregnancy, the body undergoes modulation of pro-inflammation responses to ensure fetal survival, and these adjustments may decrease maternal immune defenses and promote infections. Objectives: This study was conducted to determine interleukin 2 (IL-2), IL-10, and interferon gamma (IFN-γ) among pregnant women co-infected with HIV and Plasmodium falciparum in Edo State, Nigeria. Methods: This study was conducted at the Central Hospital, Benin City, Edo State. A total of 200 participants were enrolled, consisting of 150 pregnant women co-infected with HIV and P. falciparum and 50 non-pregnant women (as controls) who were neither infected with HIV nor P. falciparum. Venous blood specimen was collected for P. falciparum detection, CD4 T-lymphocyte estimation, and IL-2, IL-10, and IFN-γ assays using standard methods. Results: Among HIV-infected pregnant women, IL-2 (P = 0.0070), IL-10 (P = 0.0179) and IFN-γ (P = 0.1564) values were lower in primiparous women compared with multiparous women. HIV-infected pregnant women who were married had significantly higher IL-2 (P = 0.0085) and IFN-γ levels (P = 0.0332) compared with single women, while marital status did not affect the IL-10 level of pregnant women infected with HIV. Only the IL-2 levels of the HIV-infected pregnant women increased significantly (P = 0.0012) with increasing trimester. The tested cytokine levels were lower in those with malaria compared with those without malaria among HIV-infected pregnant women. Conclusions: The HIV status and not malaria infection affects the cytokine levels of pregnant women co-infected with HIV and malaria.
Dvojí výjimečnost z pohledu zahraničních studií
Authors: Baranová Petra , Márová Ivana , Kachlík Petr
Published: September 2022

Předkládaný příspěvek se zabývá fenoménem dvojí výjimečnosti, v případě tohoto článku tedy kombinací vysokého nadání a specifických poruch učení. Cílem práce bylo analyzovat současné zahraniční studie, které se zabývají identifikací a diagnostikou kognitivně nadaných žáků se specifickými poruchami učení v období povinné školní docházky. Pro tyto účely bylo analyzováno 10 zahraničních studií, které se dvojí výjimečností zabývaly v letech 2010–2019. Ve výkladové části práce přibližuje cílovou skupinu žáků s dvojí výjimečností a pojednává o vývoji přístupů k dané problematice. Dále je pozornost věnována charakteristice žáků s dvojí výjimečností v edukačním prostředí a diagnostice dvojí výjimečnosti. V části analytické je práce zaměřena především na kombinace kognitivního nadání a specifických poruch učení ve vybraných studiích a nástroje, které byly pro účely identifikace a diagnostiky dvojí výjimečnosti ve vybraných studiích použity. Závěry předkládaného příspěvku ukazují, že diagnostický proces dvojí výjimečností není jednotný. Diagnostika dvojí výjimečnosti aktuálně sestává z nezávislé diagnostiky nadání a diagnostiky specifických poruch učení, přičemž pro každou oblast může být použita široká škála diagnostických nástrojů. Výkon žáka v jednotlivých testech je ovlivněn kombinací posílených dovedností a schopností pramenících z nadání a oslabených oblastí plynoucích ze specifických poruch učení. To má za následek rozdílnou úspěšnost v identifikaci žáka s dvojí výjimečností, a to jak v závislosti na použité kombinaci diagnostických nástrojů, tak také na kombinaci nadání a oslabených funkcí. Kognitivně nadaný žák je totiž schopen využívat své dovednosti k maskování či kompenzování oslabených funkcí, jeho výsledky v rámci diagnostiky proto mohou být neprůkazné. Pro účely včasné identifikace dvojí výjimečnosti jsou diskutovány modely určené pro včasné odhalení žáků v riziku školního neúspěchu v zahraničí, konkrétně RtI model a Model diskrepance. Z analýzy ovšem vyplývá, že pro účely včasného odhalení dvojí výjimečnosti je nezbytná jejich adaptace tak, aby reflektovaly unikátní kognitivní profil žáků s dvojí výjimečností.
Participation of psychologists in Istanbul Protocol based physical examinations: an applied perspective
Authors: Weishut Daniel
Published: September 2022

Being invited to do an evaluation of another asylum seeker, this time one from Turkey, a question kept coming to my mind. The question is as follows: Wouldn’t it be important for mental health professionals to take part in Istanbul Protocol (IP) based physical examinations? The intent is not to do the physical examination, but to be present, observe, ask questions when appropriate, and witness, with the consent of the client. The article elaborates on this question, while both sharing my perspective as a clinical psychologist and referring to relevant literature.
Satisfacción, lealtad y compromiso en entornos on-line
Authors: Prado Román Alberto , Blanco González Alicia , Mercado Idoeta Carmelo
Published: September 2022

Durante los últimos años, el mercado on-line ha experimentando un progreso creciente identificándose como una oportunidad para las compañías para desarrollar su actividad comercial. Así, la investigación tiene por objeto formular un modelo explicativo del proceso de generación de lealtad del consumidor en el mercado turístico on-line. De este modo, se ha realizado un análisis de ecuaciones estructurales sobre una muestra de consumidores que han contratado servicios turísticos a través de Internet. Los resultados obtenidos en la investigación demuestran que la calidad de servicio es tanto un antecedente de la satisfacción como de la lealtad on-line. Además, se identifica que tanto la satisfacción como el compromiso son antecedentes de la lealtad on-line.
Assessment of regional measures of tax support for business in the context of the COVID-19 pandemic
Authors: Popova Evgeniya Mikhailovna , Guseinova Guzel Mukhtarovna , Goncharova Aleksandra Vladimirovna
Published: September 2022

The implementation of quarantine measures and the decline in economic activity in 2020 became an impetus for the implementation of a stimulating tax policy not only at the federal, but also at the subnational level. The article examines the experience of countercyclical fiscal policy in the OECD countries, highlights the factors of relatively modest tax support provided to small and medium-sized businesses at the subnational level. The object of the study is stimulating tax expenditures provided in accordance with the legislation of the Russian regions to support economic entities in the conditions of restrictive measures caused by the spread of a new coronavirus infection. The research methodology is based on the methods of formal logic, statistical and econometric analysis. The scientific novelty of this study consists in conducting a comprehensive analysis covering all subjects of the Russian Federation in which stimulating tax expenditures were actually provided, and assessing the regional tax policy implemented during the COVID-19 pandemic through the prism of key budget parameters and indicators of socio-economic development. The regional tax policy was carried out in conditions of large-scale fiscal support from the federal center and deterioration of the state of subnational finances due to the growth of deficit budgets. During the 2020 pandemic, the constituent entities of the Russian Federation provided tax benefits on taxes that account for a small share in the revenues of regional budgets. Since the main purpose of tax incentives was to solve liquidity problems and maintain employment, investment tax incentives for corporate income tax were not introduced in Russian regions. The study of the actual and forecast dynamics of GRP allowed us to conclude that the tax support measures implemented in the Russian subjects stimulated economic activity and helped to smooth out the negative consequences of the coronacrisis.
The importance of moral and psychological aspects in carrying out operational and service tasks of police officers.
Authors: Domysheva Tat'yana Vital'evna
Published: September 2022

The subject of the study is the legal and psychological aspects of the use of firearms by police officers.The object of the study is the psychological and emotional state of police officers in various situations, as well as the content and effectiveness of modern testing methods that determine the psychological state of a person. The objectives of the study are: - study of factors affecting the psychological state of employees; - analysis of the causes and conditions in connection with which irritable factors that affect the psycho-emotional state of a police officer arise. The scientific novelty of the work is a comparative study of the legal and psychological aspects of the use of firearms by police officers in stressful situations. Thus, in order to perform operational and service tasks, it is necessary to be ready not only theoretically and possess special skills and abilities in the implementation of their activities, but also to be morally ready to carry out their activities, as well as objectively understand that certain problems may arise in the performance of official duties. It is necessary to approach the performance of official tasks correctly, while maintaining calm. A police officer who is morally ready to perform his official duties is able to solve operational and official tasks; with the correct and confident performance of his official actions, the quality of the employee's activity increases.
Training of officers of combatant police units in the safe handling of weapons.
Authors: Rustamov Rustam Adilovich , Polyanskii Petr Georgievich , Nikolaev Nikolai Olegovich
Published: September 2022

This article discusses the system of professional training of officers of combatant police units (on the example of the security and convoy service) for the use of service weapons, training in the competent and safe use of firearms in the course of performing operational and service tasks and performing shooting exercises in typical situations of the use of firearms using special vehicles. Based on the conducted research, the author's team found that the existing training methods do not fully meet the modern requirements of professional training of employees of the security and escort unit of the Ministry of Internal Affairs of Russia. Based on this, the authors propose methods that can significantly increase the level of training of this category of employees to perform official tasks with weapons. The research methodology is presented by such empirical methods as analysis of the practice of law enforcement officers, generalization of methodological experience, modeling of educational situations. The conducted research revealed the need to develop a unified approach to the methodology of teaching tactical methods of using firearms in typical situations of operational and service activities. The study was conducted in two directions: - the first direction is related to the study of methods of teaching employees of internal affairs competent and safe (for others, including other employees included in the convoy) the use of firearms during the performance of official tasks; - identification and development of typical situations of the use of firearms employees of the security and escort units of the Ministry of Internal Affairs of Russia using special vehicles. Based on the research conducted by the team of authors, it was found that the existing training methods only partially meet the modern requirements of professional training of personnel of the security and escort units of the Ministry of Internal Affairs of Russia. As a result, a training methodology has been developed that allows to significantly increase the level of training of this category of employees to perform official tasks with firearms.
On the need to develop a unified approach to the content of the criminal procedural definition of "close relatives" in the regulation of legal relations in the Russian Federation related to the investigation of domestic crimes
Authors: Bulbacheva Anna Aleksandrovna , Kotyazhov Andrei Valer'evich
Published: September 2022

The article is devoted to the problem of legal definition of the concepts of close relatives, close persons and family members of a citizen. Inconsistencies between the norms of the Constitution of the Russian Federation and the norms of family legislation in relation to the criminal procedural category "close relatives", which ensures the provision of witness immunity in criminal proceedings. It discusses controversial issues about the circle of close relatives who have the right not to testify as witnesses. The essence of this socio-legal status is revealed, the circle of persons forming it is established, the positive and negative sides of the existing definitions and formulations of "close relatives" are considered.The scientific novelty lies, first of all, in the fact that in the presented article the norms of criminal procedure, civil and family law regulating relations of kinship, matrimony, as well as the procedure and problems of their application in criminal proceedings were considered. Paragraph 4 of Article 5 of the Criminal Procedure Code of the Russian Federation refers to spouses as close relatives, but Article 14 of the Family Code of the Russian Federation does not consider them as such. The analysis of family law allows us to conclude that kinship is possible only by "blood" (the exception is the institution of adoption). For this reason, spouses cannot be close relatives and they are in a marital relationship to each other. The proposals on amendments and additions to the Criminal Procedure Code of the Russian Federation are formulated, which will improve the domestic criminal procedure legislation within the framework of developing a unified approach to the content of the definition of "close relatives".
Formation of moral and psychological stability of police officers in cases of obstruction of their legitimate actions
Authors: Vorozhtsov Aleksandr Mikhailovich , Zhukov Viktor Mikhailovich , Orlov Vladimir Vladimirovich
Published: September 2022

Employees of the internal affairs bodies in their official activities constantly face a high degree of psycho-emotional stress. In law enforcement practice, there are cases of obstruction of the performance of official duties by police officers. In case of obstruction of legitimate activities, employees of the Department of Internal Affairs may experience negative emotions. These emotions are a response of the psyche to external circumstances. Obstructing the legitimate actions of police officers often leads to conflict situations in which it is necessary to maintain balance and control over their actions or statements, and based on the current situation to make a decision in accordance with the current legislation. Obstruction of the performance of official duties, as a rule, is of a pronounced conflict nature. To increase the effectiveness of classes, it is advisable to involve experienced employees as experts in conducting a business game. This will ensure the necessary exchange of professional experience and increase the effectiveness of training. A large number of different possible situations are simulated, the social and role experience of employees participating in the training is expanded, their gradual involvement in the business game takes place. It becomes obvious that there is a need to organize work on the formation and development of moral and psychological stability among police officers and to teach them techniques for managing their emotional state.
Functional-semantic and expressive potential of the oxymoron in Russian poetry of the XIX century.
Authors: Faizullina Nargiza Damirovna
Published: September 2022

Abstract The present article is devoted to the study of antonyms as a stylistic device based on opposites and contradictions, the identification of means of expressiveness. The object of the study is the stylistic figure “oxymoron", considered on the material of poetry of the XIX century. The purpose of the research is to reveal and comprehend the specific essence and features of the oxymoron as a category of poetics, to identify the relationship with the verbal poetic image as a kind of absurdity and paradox. The acceptance of speech paradoxes is explained by allophrony. Special attention is paid to the structural and semantic possibilities of an antonymic pair in the context of a deliberately used speech error. The work is carried out in line with the descriptive method of linguistics. The results of our linguistic research allow us to draw some conclusions: that the linguistic phenomenon is an oxymoron, is anomalous to words with a direct meaning and is characterized in science as a paradox. The acceptance of speech paradoxes, despite the contradictions, is explained by allophrony. The increased expressiveness of the oxymoron is achieved by contrasting, opposites, a combination of epithets incomprehensible to logic, in which a vivid manifestation of feelings, moods, thoughts is expressed, it is implied as an incorrect, unfair combination of ideas in one whole, that is, as a violation, as something that does not have the right to exist in a work of art due to inconsistency, logically mutually exclusive each other even before direct interaction. The oxymoron as a phenomenon of poetic and empirical reality is used as metaphorical names of any physiological deviations in the description of heroes, anomalies in nature containing a paradox. The minimal structure of the oxymoron is a phrase, it is the result of a fusion of contrasting meanings. An adjective and a noun interact in an oxymoron, less often an adverb and a verb, a verb and a adverb, an adverb and an adjective.