bluuebunny/crossref_metadata_2025 huggingface dataset:
Cohort Profile: Beijing Healthy Aging Cohort(BHACS)
Authors: Liu Miao , Yang Junhan , Wang Chunxiu , Yang Shanshan , Wang Jianhua , Hou Chengbei , Wang Shengshu , Li Xiaoying , Li Fang , Yang Hongbing , Li Haowei , Liu Shaohua , Chen Shimin , Hu Shimin , Li Xuehang , Li Zhiqiang , Li Rongrong , Li Huaihao , Bao Yinghui , Shi Yueting , Tang Zhe , Fang Xianghua , He Yao
Published: March 2023

BHACS was established to fill the lack of a large representative cohort of the elderly based on general populations and was designed to evaluate the prevalence, incidence, and natural history of cognitive decline, functional disability, and conventional vascular risk factors. The objectives were to determine the evolution of those diseases by estimating rates and impact factors of progression and reversion to adverse outcomes including dementia, cardiovascular events, cancer, and all-cause death. Therefore, it can provide evidence to help policy-makers develop better policies to promote healthy aging in China.
BHACS was formed by three cohorts in Beijing with a total population of 11 235 (6281 in urban, 4954 in rural), the baseline survey time and follow-up time differed between the three. BLSA was followed up in 2014 with the baseline survey completed in 2009; CCHS-Beijing was followed up twice in 2015-2016 and 2018-2019 as its baseline survey was performed in 2013-2015; BECHCS was followed up every two or three years with the baseline investigation completed in 2010-2014.
Data were collected using questionnaires, physical measurements, and laboratory analysis. Topics of BHACS include numerous physical and mental health indicators, living habits, and personal, familial, and socio-economic health determinants. There is no immediate plan to make the cohort data freely available in the public domain, specific proposals for further collaboration are welcome.
Improve the efficiency and accuracy of ophthalmologists' clinical decision-making based on AI technology
Authors: Guo Yingxuan , Huang Changke , Sheng Yaying , Zhang Wenjie , Ye Xin , Lian Hengli , Xu Jiahao , Chen Yiqi
Published: March 2023

Objective
This article proposes a named entity recognition model for electronic medical records in ophthalmology that integrates professional vocabulary information. The aim is to achieve structured processing of important clinical decision-making data and to develop a clinical aided diagnosis platform based on this. The effectiveness of this platform in improving the efficiency and accuracy of ophthalmologists in clinical diagnosis decision-making was validated.
Methods
Based on the best entity recognition model, we constructed the aided diagnosis platform. By conducting a controlled experiment that compared the use of the platform by doctors with different levels of experience, we analyzed the effectiveness of the aided diagnosis platform in improving diagnosis decision-making efficiency and accuracy.
Results
The SoftLexicon-Glove-Word2vec model had the highest F1 score at 93.02%. Both junior and senior doctors showed significant improvement in diagnosis efficiency and accuracy (P < 0.05) when using the platform. Regardless of whether the aided diagnosis platform was used or not, there were significant differences in diagnosis decision-making efficiency and accuracy between junior and senior doctors (P < 0.05).
Conclusion
The use of artificial intelligence technology to construct the aided diagnosis platform for fundus diseases can effectively improve the clinical decision-making ability of junior doctors, and improve the diagnosis efficiency and accuracy.
Web Accessibility in the Field of Social Services and Benefits in Romania
Authors: Marin Anca Monica , Popa Liliana
Published: March 2023

This paper examines the current situation in Romania in terms of web accessibility provided by two key institutions in the field of administering social services and benefits in Romania – County Directorates of Social Work and Child Protection (DGASPC) as well as County Pensions Houses (CJP). As the pandemic context further accelerated development of e-government worldwide, there is a strong need to ensure information and communication accessibility for persons with disabilities and persons with functional limitations in general. The assessment grid is represented by the Web Content Accessibility Guidelines (WCAG) 2.1 requirements and techniques, mainly regarding Level A, minimum level of conformance. Results underline significant discrepancies on implementing various accessibility characteristics among similar institutional bodies and the needs to take further steps on improved accessibility. The study adds knowledge on the larger topic of digital inclusion, as a contributor to enhanced social inclusion. It also contributes to the international debate on web accessibility evaluation and developing accessibility in web design, especially in the case of public authorities who have under their responsibility services directly addressed to persons with disabilities or to older persons with visual or hearing impairments.
The synzootic potential of common epidemics in chamois populations
Authors: Garrido-Amaro Cristina , Jolles Anna , Velarde Roser , López-Olvera Jorge Ramón , Serrano Emmanuel
Published: March 2023

Southern chamois (Rupicapra pyrenaica) is a medium-sized and gregarious mountain ungulate with populations affected by periodic outbreaks of border disease virus (BD), infectious keratoconjunctivitis (IKC), and sarcoptic mange (SM). Even though the impact of each disease on chamois populations has been described in detail, there is a lack of information about the potential impact of concomitant epidemics and the synzootic potential (co-occurring enzootic or epizootic processes producing worse health outcomes in wildlife) on chamois populations. Furthermore, whether a specific order of apparition of epidemics is more or less harmful for the host population is practically unknown not only for chamois but also for most mammal populations. Using a population viability analysis (PVA), we studied the consequences of multiple disease outbreaks with synzootic potential on growth rates and probabilities of extinction of virtual populations exposed to hard winters, density dependence and co-occurring BD, IKC and SM outbreaks. Such infections are not under cross-immunity nor density-dependent processes and thus are supposed to affect population demography independently. Heavy snowfalls are also likely to occur in our simulated populations. Our simulations showed that a second outbreak, even caused by a low virulent pathogen, causes an increase in the probability of extinction of the host population with regard to the first outbreak. IKC-BD and SM-BD affected populations had a higher risk of becoming extinct in 50 years confirming the extra risk of multiple outbreaks on the viability of the affected populations.
The EuFe2As2 magnetic state peculiarities as revealed by ESR
Authors: Talanov Yurii , Gimazov Ilnur , Zaripov Ruslan , Pervakov Kirill , Vlasenko Vladimir , Pudalov Vladimir , Teitel'baum Gregory
Published: March 2023

The magnetic state of the EuFe2As2 single crystal was investigated by means of electron spin resonance (ESR). ESR spectra of europium ions were obtained in the temperature range from 250 K to 4 K. To study the anisotropy, the in-plane angular dependences were obtained at temperatures of 15 K upon rotating a crystal around c-axis. The data analysis has shown that EuFe2As2 is an antiferromagnet with an easy anisotropy plane. Moreover, the second-order easy magnetization axis is observed for each of the two types of magnetic domains connected to structure twins arising from the tetragonal-to-orthorhombic crystal lattice transition.
Genome-wide detection of CNV regions between Anqing six-end-white and Duroc pigs
Authors: Qian Rong , Xie Fei , Zhang Wei , Dong Wei , Kong JuanJuan , Zhou Xueli , Wang Chonglong , Li Xiaojin
Published: March 2023

Anqing six-end-white pig is a native breed in Anhui Province. The pigs have the disadvantages of a slow growth rate, low proportion of lean meat, and thick back fat, but feature the advantages of strong stress resistance and excellent meat quality. Duroc pig is an introduced pig breed with a fast growth rate and high proportion of lean meat. With the latter breed featuring superior growth characteristics but inferior meat quality traits, the underlying molecular mechanism that causes these phenotypic differences between Chinese and foreign pigs is still unclear. In this study, copy number variation(CNV) detection was performed using the re-sequencing data of Anqing Six-end-white pigs and Duroc pigs, A total of 65,701 CNVs were obtained. After merging the CNVs with overlapping genomic positions, 881 CNV regions (CNVRs) were obtained. Based on the obtained CNVR information combined with their positions on the 18 chromosomes, a whole-genome map of the pig CNVs was drawn. GO analysis of the genes in the CNVRs showed that they were primarily involved in the cellular processes of proliferation, differentiation, and adhesion, and primarily involved in the biological processes of fat metabolism, reproductive traits, and immune processes. The difference analysis of the CNVs between the Chinese and foreign pig breeds showed that the CNV of the Anqing six-end-white pig genome was higher than that of the introduced pig breed Duroc. Six genes related to fat metabolism, reproductive performance, and stress resistance were found in genome-wide CNVRs (DPF3, LEPR, MAP2K6, PPARA, TRAF6, NLRP4).
Effect of Pantanal Fire Events on the Secondary Metabolism of Plants
Authors: Siqueira Camila Sório , Santos Vanessa Samúdio dos , Júnior Geraldo Alves Damasceno , Carollo Carlos Alexandre
Published: March 2023

We investigated the effects of fire on the secondary metabolites ofRhamnidium elaeocarpumin the Pantanal region. We analyzed the total phenol and tannin content of individuals from four different sampling groups and used LC-MS metabolomics techniques to observe the metabolites present in the samples and the thermogravimetric behavior of the species. Our findings suggest that recent fires did not significantly affect the species' phenolic metabolism, except for specimens affected by the 2020 megafire, which exhibited a decline in compounds due to leaching. The data suggests that recent fire incidents did not impact the phenolic metabolism of the species, and the high levels indicate that the species has a biochemical tolerance to the stress caused by seasonal fires. Metabolomic profiles showed intense biosynthesis of proanthocyanidin oligomers, which protect against oxidative stress and post-fire environmental disturbances. The results of the thermogravimetric behavior showed the species' thermotolerance and intrinsic relationship with secondary compounds. Overall, our study advanced our understanding of the impact of fire on woody species' metabolism. However, distinguishing whether chemical traits are an adaptive feature or a response to surrounding environmental factors presents a challenge.
Morphological and Phylogenetic Analyses Reveal a New Species of Anthracophyllum (Omphalotaceae, Agaricales) in Zhejiang Province, China
Authors: Yang Wen-Juan , Xu Miao , Zhang Jing , Zhou Fan , Le Zhi-Fang , Tong Wen-Jun , Song Hai-Yan , Jin Zhuo-Han , Cheng Qiu-Ge , Zhou Jian-Ping , Gao Yang , Zhai Zhi-Jun , Hu Hai-Jing , Chen Ming-Hui , Yin Hua , Wang Jiang , Hu Dian-Ming
Published: March 2023

During the investigations of macrofungi resources in Zhejiang Province, China, an interesting wood rot fungus was collected. Based on morphological and molecular phylogenetic studies, it was described as a new species Anthracophyllum sinense. A. sinense is characterized by its sessile, charcoal black and pleurotoid pileus; sparse, occasionally branches lamellae; oval basidiospores measuring (8–)9–11.2–13(–14) µm × (5–)6–6.6–8(–9) µm, with obvious spore tips; clavate basidia with obvious sterigmata; and non-heteromorphous cystidium. A. sinense established a separate lineage that was similar to A. archeri and A. lateritium in the phylogenetic tree.
A Context-Aware on-board Intrusion Detection System
Authors: Micale Davide , Matteucci Ilaria , Fenzl Florian , Rieke Roland , Patanè Giuseppe
Published: March 2023

Modern vehicles are becoming increasingly attractive from the perspective of possible intruders. The main reasons are twofold: modern vehicles are now connected to the outside world via Wi-Fi, Bluetooth, and mobile connection, such as LTE and 5G, and the increasing complexity of the on-board software enlarges the attack surface. In this article, we introduce CAHOOTv2, a context-sensitive intrusion detection system (IDS) that uses the vehicle’s sensors to determine driver habits and gather information about the environment to detect intruders. We use hyperparameter tuning to increase detection accuracy. To demonstrate the validity of the algorithm, we collected driving data from both an Artificial Intelligence (AI) and 39 humans. We include the AI driver to demonstrate that CAHOOTv2 is able to detect intrusions when the driver is both a human or an AI. The dataset is obtained using a modified version of MetaDrive simulator where we consider also the presence of an intruder able to perform the following types of intrusions: denial of service, replay, spoofing, additive and selective attacks. We make several experiments showing the benefits of hyperparameters tuning. The results of CAHOOTv2 are promising on detection of intrusions.
Global Well-Posedness for Eddy-Mean Vorticity Equations on T2
Authors: Cacchio' Yuri
Published: March 2023

We consider the two-dimensional, β-plane, eddy-mean vorticity equations for an incompressible flow, where the zonally averaged flow varies on scales much larger than the perturbation. We prove globalexistence and uniqueness of the solution to the equations on periodic settings.
Mathematics Subject Classification (2010). 35Q86.
The interlayer shear stress in a double-layered tube of finite length with cylindrical orthotropy and radial inhomogeneity subjected to end torsional loads
Authors: Wang Chung-Hao
Published: March 2023

The elastic torsion problem for a circular tube which contains two perfectly bounded layers of finite length is analyzed herein with the emphasis placed on the interlayer shear stress at the bonded interface. The material property for each layer is considered both cylindrically orthotropic and radially inhomogeneous. Analytical solutions for the whole structure are derived via a unified methodology and the shear stress on the bonding interface is readily available and thoroughly investigated. The results reveal that the interlayer shear stress near the end will arise when the end torsional load differs from the associated Saint Venant torsion. And a particular material property relationship existing between two layers and under a particular end loads is found that the end effects inducing the interlayer shear stress can be fully eliminated. Concluding from the investigations analyzed using the derived general solutions, the distributions and the variation trends of the interlayer shear stress at the bonding interface subject to the variations of the main controlled parameters are discussed and summarized.
DNA response and repair gene mutations as a signature for pembrolizumab response in never-smoker non-small lung cancer: real word approach and patient similarity network analysis
Authors: Filetti Marco , Occhipinti Mario , Cirillo Alessio , Scirocchi Fabio , Ugolini Alessio , Giusti Raffaele , Lombardi Pasquale , Daniele Gennaro , Botticelli Andrea , Russo Giuseppe Lo , Braud Filippo Maria , Marchetti Paolo , Nuti Marianna , Ferretti Elisabetta , Farina Lorenzo , Rughetti Aurelia , Petti Manuela
Published: March 2023

Purpose
Single-agent immune checkpoint inhibitor (IO) therapy is the standard of care for non-oncogene addicted advanced non-small cell lung cancer (aNSCLC) with PD-L1 ≥ 50%. High tumor mutation burden (H-TMB) is a notable biomarker for IO response. Smoking-induced harm generates H-TMB in smoking aNSCLC patients (S-pts), whereas never-smoking patients (NS-pts) usually have low TMB and are IO-unresponsive. However, NS-pts with H-TMB have not been well molecularly characterized.
Experimental design
Clinical data of 142 aNSCLC patients with PD-L1 ≥ 50% treated with first-line pembrolizumab were retrospectively collected. Next-generation sequencing was performed using the FoundationOne®CDx assay to correlate genomic alterations with clinical characteristics and response outcomes. Detected mutations were classified into eleven main pathways: cell cycle, Hippo, Myc, Notch, oxidative stress/Nrf2, PI3K, RTK/RAS/MAP, TGF-b, p53, b-catenin/Wnt, and DDR. Enrichment analysis was performed on pathways with at least one mutation per patient to characterize patient subgroups based on mutated pathways. Moreover, to further investigate the molecular characterization of patients’ subgroups, we built and analyzed the patient similarity network exploiting the mutational profile to compute the pairwise similarity between patients.
Results
There were 111 S-pts and 31 NS-pts; S-pts had higher TMB (median TMB: 8 vs. 4 Mut/Mb). However, 11 NS-pts had high TMB (median TMB: 16.39 Mut/Mb) and were significantly enriched in b-catenin/Wnt and DDR pathway mutations (p-values=0.0027 and 0.0014, respectively) compared to others and H-TMB/S-pts. Using publicly available molecular characterization data (of 853 NSCLC patients from 2 randomized controlled trials), DDR pathway mutations were confirmed to be enriched in NS-pts with H-TMB. In the real world cohort the subgroup of H-TMB/NS-pts with DDR pathway mutation showed better IO response and survival. Moreover, the similarity network analysis of the NS-pts revealed the presence of one subgroup characterized by high TMB, improved OS and a prevalence of DDR pathway mutations.
Conclusions
DDR signature has a potential role as additional generator of H-TMB in NS-pts. This subgroup of IO-responsive NS-pts may have better prognosis.
Posterior unilateral small fenestration of lamina combined with a custom-made Y-shaped fracture reduction device for the treatment of severe thoracolumbar burst fracture：a prospective comparative study
Authors: Zeng Zheng , Zhang Dan , Zeng Fen-Lian , Ao Jun
Published: March 2023

Background
For the purpose of evaluating the clinical effect of a custom-made Y-shaped fracture fragment reduction device, and to assist in posterior unilateral small fenestration of lamina to reduce the fracture fragments.
Methods
In this study, 40 patients were assigned to one of two groups: the traditional reduction device group (TRG) or the Y-shaped reduction device group (YRG) (YRG). All patients underwent posterior unilateral small fenestration of the lamina and direct decompression through the spinal canal. And the operation time (OT), intraoperative blooding (IB), preoperative, postoperative, and final follow-up data on the spinal stenosis rate (SSR), Cobb angle, the anterior compression ratio of injured vertebrae (ACRIV), and ASIA neurological function grade were compared between the two groups.
Result
There were no complications, including vascular and nerve injury, serious postoperative infection, internal fixation fracture, or loosening, for any of the patients. And the average follow-up time of the two groups was 14.2 months, the average operation time of the TRG was 236.6 minutes, and the average intraoperative blood loss was 357.20 ml. Moreover, the average operation time of the YRG was 190.6 min, and the average intraoperative blood loss was 241.5 ml. There were significant differences between the two groups in terms of operation duration and intraoperative blood loss. The YRG's was lower than that of the TRG. Besides, there was no difference in SSR, Cobb angle, ACRIV, or neurological recovery between the two groups before or immediately after the operation or at the last follow-up.
Conclusion
The Y-shaped fracture reduction device can reduce the fracture fragments and the OT and IB stably; it also has satisfactory postoperative curative effects and clinical utility.
Measuring DEI Awareness, Empowerment, and Action Orientation: Validation of the Health Professions Educators Diversity, Equity, and Inclusion Scale (HPE DEI)
Authors: Gesing Peggy , Lynch R. Jason , Burbage Amanda K.
Published: March 2023

Educating students in health occupations about the need to consider DEI in their practice can lead to improved health care outcomes for all populations. Measuring health professions educators’ awareness, empowerment, and action orientation toward diversity, equity, and inclusion (DEI) is one step toward addressing disparities in health care. In this article, thedevelopment and examination of the psychometric properties of the Health Professions Educators Diversity, Equity, and Inclusion Scale (HPE DEI) are described. Exploratory factor analysis was performed on data collected from health professions educators at seven higher education institutions in the United States. Factor analysis resulted in a three-factor structure measuring awareness, empowerment, and action orientation of health professions educators as they address issues of diversity, equity, and inclusion in their teaching. The resulting scale provides a nuanced way to explore the competencies necessary for effectively considering diversity, equity, and inclusion in health professions education. The HPE DEI is adaptable for educators across degree levels and academic disciplines.
‘Its the Economy Stupid’: Predictive Theory of Belief Shift Connecting Economic Stress to Societal Polarization
Authors: Yang David , EVans James , Chattopadhyay Ishanu
Published: March 2023

Despite growing concerns about increasing societal polarization, its mechanics remain unclear. A lack of consensus in how to measure and analyze polarization, that takes more than a few hand-picked variables into consideration, have hindered progress. Our new framework (CogNet) computationally distills emergent dependencies between diverse opinions, which then allow us to infer digital twins of society-wide survey responses. In addition to enabling reliable opinion prediction at the individual level to thousands of controversial questions, CogNet allows us to objectively assess societal polarization from social survey data. Analyzing >65K US respondents from the General Social Survey, and > 3.9M European Union participants from the Eurobarometer over half a century, here we provide new evidence that faltering economies forecast greater polarization, and that affective polarizationis a precursor to ideological polarization, yielding insight into how cultural clusters fragment with economic stress, leading to widening gaps between dominant ideologies.
Recovery of copper from deposit of Kola Tembein, Tigray, Ethiopia
Authors: Gebreslasie Tesfay Negassi , Berhe Goitom Gebreyohannes , Cheru Mulugeta Sisay , Tesfay Gebreyohannes Gebrehiwet
Published: March 2023

One of the most significant sources of copper metal is malachite ore. The world's demand for copper is being positively impacted by increased extraction. However, the chemical compositions of copper in the malachite ore, which vary depending on the region, determine how well copper may be extracted. This study evaluated hydrometallurgical processing of copper metal from malachite ore of Kola Tembein, Tigray, Ethiopia. Malachite ore was processed hydrometallurgical with sulfuric acid to leach copper metal, which was then recovered using a cementation process of zinc metal. The samples were examined with XRD, EDXRF, SEM, and AAS. The rock ore sample examined by XRD contained a variety of minerals, including malachite (Cu2CO3(OH)2), quartz (SiO2), Albite Ca-rich (Ca Al2Si2O8), Albite disorder (NaAlSi3O8)m etc. and the morphology of malachite ore was supported by SEM. According to the EDXRF results, the malachite ores were dominated by metal oxides of CuO (58.21), SiO2 (19.21), and Fe2O3 (5.32) by weight%. Similar spectroscopic results were shown for Turkey, China, Chile, and Nigeria malachite. The leaching experiments were optimized by BBD using the RSM to leach malachite at 2.6130 M H2SO4, 133.919 m particle size, 60 0C, and 600 rpm agitation speed, and scored 98.159%. Using the cementation process, red-brown copper metal was obtained, and waste was scored by AAS as having very low concentrations of copper (1.74 mg/L) and high concentrations of zinc ions (68.85 mg/L). Both the leaching and cementation processes are best environmentally and economically, and further purification will be needed to recover zinc from the waste
YOLO-ERF: Lightweight Object Detector for UAV Aerial Images
Authors: Wang Xin , He Ning , Hong Chen , Sun Fengxi , Han Wenjing , Wang Qi
Published: March 2023

The application of object detection techniques in the field of unmanned aerial vehicles (UAVs) is an important research direction in computer vision. Because object detection in UAV aerial images needs to meet real-time requirements, a challenging problem in this technology is the trade-off between network parameters and detection accuracy. To solve this problem, this paper proposes a lightweight object detector family named YOLO-ERF. First, this paper proposes the effective receptive field (ERF) module, which can increase the convolutional kernel receptive field while preserving local details. The ERF module is then used to design a lightweight backbone to expand the network receptive field without the need for attaching additional context modules after the backbone to expand the receptive field. In addition, the proposed detectors use the ERF module to critically optimize the path aggregation network structure to improve the accuracy with reduced network parameters. Finally, a lightweight detection head is proposed to improve small object recognition in complex backgrounds. With these optimizations, the YOLO-ERF models in this paper achieved a better trade-off between accuracy and parameters than other mainstream models, achieving strong results on the VisDrone and COCO datasets. YOLO-ERF-T reduced the number of network parameters by 40.3% when compared with YOLOv7-Tiny, while increasing the average accuracy by 2.4% and 1.9%, respectively, in VisDrone and COCO datasets.
Distribution and growth of bivalve molluscs Macoma calcarea (Gmelin, 1791) in the Kara Sea
Authors: Lisitsyna Kseniya N. , Gerasimova Alexandra V.
Published: March 2023

This study is devoted to the analysis of distribution and linear growth of Macoma calcarea in the southwestern part of the Kara Sea based on the results of observations (119 stations at depths from 4 to 415 m) in August-September 2012–2013. It appeared that for at least the last 100 years M. calcarea has been a characteristic component of coastal bottom communities in the southwestern part of the Kara Sea and sometimes dominated by biomass. The densest beds of M. calcarea were confined to the silty biotopes at depths less than 50 m. Within this depth range, it was possible to associate the distribution of molluscs only with the characteristics of bottom sediments. The highest values of Macoma biomass and density (up to 90 g m− 2 and 120 ind. m− 2, respectively) differed in habitats with a rather high content of silt in the bottom sediments (more than 80%), which quite logically corresponded to the trophic characteristics of this species. The influence of interspecific relationships on the distribution of Macoma was not revealed. The maximum size and age of M. calcarea (37 mm and 21 years, respectively) in the southwestern part of the Kara Sea, the average annual growth rate (about 2 mm/year) turned out to be close to those of this species in other areas of distribution. It was shown that the results of the age determination of specimens by the external morphology and inner marks (shell cross-sections) were quite comparable. Individual and group growth of Macoma were characterized by weak heterogeneity within the studied water area. The individual growth of molluscs, apparently, is mostly determined by the characteristics of the initial period of molluscan growth.
Repetitive Research: A Conceptual Space and Terminology of Replication, Reproduction, Re-Implementation, Re-Analysis, and Re-Use in Computational Literary Studies
Authors: Schöch Christof
Published: March 2023

This article is motivated by the ‘reproducibility crisis’ that is being discussed intensely in fields such as Psychology or Biology but is also becoming increasingly relevant to Natural Language Processing and Digital Humanities. Using the phrase ‘repetitive research’ as an umbrella term, and with the objective to provide clarity and help establish best practices in this area, this article focuses on two issues: First, the conceptual space of repetitive research is described across five key dimensions, namely those of the research question or hypothesis, the dataset, the method of analysis, the team involved, and the results. Second, building on this new description of the conceptual space and on earlier terminological work, an easily understandable terminology for recurring scenarios of repetitive research is proposed. For each scenario, its typical purpose and added value in the research process are discussed, the requirements for enabling it are described, and it is illustrated using examples from the domain of Computational Literary Studies. The key contribution of this article, therefore, is a proposal for a transparent terminology underpinned by a systematic model of the conceptual space of repetitive research.
A pilot study on metabolomic characterization of human glioblastomas and patient plasma
Authors: Liu Yin Allison , Aboud Orwa , Dahabiyeh Lina A. , Bloch Orin , Fiehn Oliver
Published: March 2023

Purpose
To determine whether recurrent GBMs are metabolically distinct from primary GBM, and whether patient plasma can be used as a liquid biopsy to reflect this difference.
Methods
In a single center cohort study, tissue and blood samples from 15 patients with glioblastoma (9 glioblastoma tissues at diagnosis, 3 pairs of tissue, and 6 pairs of plasma specimens at diagnosis and at recurrence) were analyzed.
Results
Several metabolites had significant alternations in both tumor and plasma specimens. In the tissue, the following representative metabolites had a significant increase in peak intensity at recurrence compared to diagnosis: N-alpha-methylhistamine (p = 0.037), glycerol-3-phosphate (p = 0.029), phosphocholine (p = 0.045), and succinic acid (p = 0.025). In patient plasma, metabolites that significantly increased at recurrence included: 2,4-difluorotoluene (p = 0.031), diatrizoic acid (p = 0.032), indole-3-acetate with (p = 0.029), urea (P = 0.025), pseudouridine (p = 0.042), and maltose (p = 0.035). Metabolites that significantly decreased in plasma at recurrence were: eicosenoic acid (p = 0.017), glucose-1-phosphate (p = 0.017), FA 18:2 (linoleic acid) (p = 0.017), arginine (p = 0.036), fatty acids 20:3 (homo-gamma-linolenic acid (p = 0.036), galactosamine (p = 0.007), and FA 18:3 (linolenic acid) (P = 0.012). Principal component analysis showed that the metabolomic profiles differ between tumor tissue and patient plasma.
Conclusions
Our data suggest that metabolomic profiles of human GBM tissue and patient plasma differ at diagnosis and at recurrence. Many metabolites involved in tumorigenesis and metabolomic flexibility were identified. A larger study using targeted metabolomic assay is warranted to measure the levels of these metabolites, which will help identify the metabolomic signatures in both GBM tissue and patient plasma for risk stratification, clinical outcome prediction, and development of new adjuvant metabolomic-targeting therapy.
Polarimetric study of the solar corona during the total solar eclipse on July 02, 2019 with a liquid crystal polarimeter
Authors: Liberatore Alessandro , Zender Joe , Capobianco Gerardo , Fineschi Silvano , Panasenco Olga , Tomuta Dana , Castillo Manuel , Pérez-Ayúcar Miguel
Published: March 2023

The results obtained during the total Solar Eclipse on July 2, 2019, in Chile are presented together with the Eclipse K-corona Polarimeter (EKPol). The EKPol is equipped with an electro-optically modulating Liquid Crystal Variable Retarder (LCVR) for the polarimetric observation of the solar corona. The use of this technology has been an important ground-based test for the application of this technology in space-based observatories. The usage of LCVRs in a polarization rotator configuration, allows the replacement of mechanically rotating retarders avoiding moving parts and reducing noise, failure probability, and mass. Indeed, EKPol was developed as a technology demonstrator for the Metis coronagraph on-board Solar Orbiter. The results, from the composition of the image to the electron density map evaluation, are compared and are consistent with what is obtained by other ground-based and space-based instruments, and with past EKPol campaigns.
Threshold and power of pulsed red-emitting diode lasers with a bulk active layer near p-cladding under high-temperature operation
Authors: Ryvkin Boris S. , Avrutin Eugene A.
Published: March 2023

Threshold properties and pulsed output of AlGaInP visible-emitting lasers with an asymmetric waveguide structure and a bulk active layer are analysed. The effects of the current leakage, increased by the heating of the laser due to the proximity of the electrical pulse source and the Joule heating in and around this source are analysed. When optimising the laser design, waveguiding properties of the bulk active layer are shown to be important, leading to threshold currents decreasing, and injection efficiency increasing, with active layer thickness in lasers with moderately thick (< 0.1 µm) active layers. Catastrophic optical degradation is shown to set an upper limit to the optimal active layer thickness.
VALIDATION OPTIMIZATION ENVIRONMENT FOR IMPROVED SELECTION OF SOFTWARE COMPONENTS: CONCEPTUAL MODELING AND ARCHITECTURE
Authors:   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, CÃ´te dIvoire., Kouakou Ive Arsene Koffi ,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Konan Marcellin Brou ,   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, CÃ´te dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Appoh Kouame ,   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, CÃ´te dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Abel Assielou Kouame ,   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, CÃ´te dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT).
Published: March 2023

Responding to the needs of a user, the selection of software components for building computer applications is a crucial step. In the matter, optimization tools exist to experiment the developed models. However, these tools are not suitable for the user and especially for a non-expert. In this article, we propose to build a software environment validating our optimization model. It is therefore an automatic aid simulator for the choice of software components of websites for the construction of modular systems. By using the method of analysis in particular the unified process of UML, at the end of our conceptual modeling, the diagrams of classes, sequences and activities are obtained. Moreover, a simulator architecture, an operation algorithm and an optimization algorithm capable of improving the choice in the selection of software components among the existing software libraries are built. Our simulator system environment is nearing completion.
LA MOLE HYDATIFORME INVASIVE: A PROPOS DUN CAS ET REVUE DE LA LITTERATURE
Authors:   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., Ouakka F. , Benaboud Z. ,   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., Saoud K. ,   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., Mamouni N. ,   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., Errarhay S. ,   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., Bouchikhi C. ,   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., Banani A. ,   Service de Gynecologieobstetrique I du CHU HASSAN II, Faculte de Medecine, de PharmacieEtdeMedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc., El Mounssefe G. ,   Service de Radiologie, du CHU HASSAN II, Faculte de Medecine, de Pharmacie et de MedecineDentaire de luniversite Sidi Mohamed Ben Abdellah, Maroc.
Published: March 2023

Background: Invasive mole is a subtype of gestational trophoblastic disease (GTD) that usually develops from malignant transformation of trophoblastic tissue after evacuation of the mole. Invasive mole occurs mainly in women of childbearing age, whereas it is extremely rare in postmenopausal women. Observation: This is a 42-year-old cholecystectomized G3P2 patient who was referred for suspected GTD and whose pelvic echo and abdominal-pelvic CT scan revealed a hypervascularized image filling the uterine cavity, invading the myometrium to the serosa without invasion. The patient underwent total interannexal hysterectomy and chemotherapy with satisfactory clinical and biological follow up. Conclusion: Our case highlights the difficulties of diagnosing invasive moles in the absence of a significant history of gestational trophoblastic disease. This study reviews the diagnostic methods, histological features and therapeutic recommendations.
THE PORTUGUESE ACCOUNTANTS: A IMPORTANT ROLE ON MANAGEMENT ACCOUNTING USE? AND IN FIRM PERFORMANCE?
Authors:   PhD in Management, Administration Department, Portuguese Military Academy, CINAMIL, Lisbon., Jorge Alves Gomes Paulo
Published: March 2023

Currently the role of accountants in firms is changing. Increasingly, accountants should have adequate skills not only in terms of financial accounting, but also skills in terms of management accounting that help in the decision-making process and in the performance of firms.The use of management accounting practices, and the respective instruments, has been gaining more and more importance in the business sector, presenting very satisfactory results, contributing greatly to the achievement of a companys competitive advantage over others operating in the same field of activity.There are some studies that suggest a weak influence on the role of management accounting in the decision-making process and in firm or organizational performance, however, they are already somewhat old, namely from the end of the 20th century. However, more recent studies show that many small and medium-sized firms cannot survive in the first years of activity, possibly due to a lack of specialists in decision-making support and they didnt implement Management Accounting (MA).The research objective of this article isto analyse the role of the Portuguese accountant, his skills and how the use of MA can contribute to the firm performance.To meet the research objective, it was decided to apply a quantitative analysis. It was developed a reflective structural equation model (SEM), using a Partial Least Squares method (PLS-SEM), which reveals the influence and impact of the Portuguese accountant and the MA on the firm performance.The results obtained allowed us to conclude that accountants in Portugal recognize the relevance of financial accounting and management accounting for the firm performance, however, they do not give relevance to the complementarity, use and applicability of these two accountings. For accountants in Portugal, management accounting is a complement to the firm performance, not being relevant to financial performance and is less important than financial accounting.
MOBILITY MANAGEMENT IN A CROSS-DOMAIN SDN ARCHITECTURE LEVERAGING THE IPV6 MOBILE PROXY
Authors:   Laboratoire de Recherche en Informatique et Telecommunication, Institut National Polytechnique Felix Houphouet-Boigny, Yamoussoukro, Cote dIvoire., Adon Jean Rodrigue Kanda Akichy , Ferdinand Atta Amanvon ,   Unite de Recherche et dExpertise Numerique, Universite Virtuelle de Cote dIvoire, Abidjan, Cote dIvoire., Babri Michel ,   Laboratoire de Recherche en Informatique et Telecommunication, Institut National Polytechnique Felix Houphouet-Boigny, Yamoussoukro, Cote dIvoire., Dooguy Kora Ahmed ,   Ecole Superieure Polytechnique, Universite Cheikh Anta Diop, Dakar, Senegal.
Published: March 2023

Mobility and technology have become inseparable terms in the sense that users want to stay connected and continue to use their services while moving. The various technologies that manage mobility face fundamental challenges such as optimizing intra-domain and inter-domain routes.With the emergence of Software-Defined Networking (SDN), a promising technology that separates the control plane from the data plane in network devices, mobility management could benefit from its advantages and thus address the above challenges. In this paper, we propose a new method of communication during the movement of a mobile node between two different domains based on the operation of the PMIPv6 protocol in a software defined networking (SDN) architecture and the involvement of edge nodes to anticipate the new destination of the mobile node. The proposed method is inspired by proactive and reactive inter-domain handovers and allows the controller to anticipate inter-domain communication with its peers and simultaneously reduce the handover time in the visited domain and the data transfer delay. The experimental results confirmed the effectiveness of the proposed method.
SURGICAL OUTCOME OF CORNEAL TRIPLE PROCEDURE IN THE MANAGEMENT OF CASES OF CORNEAL AND LENTICULAR OPACITIES IN A TERTIARY CARE HOSPITAL
Authors:   Post Graduate Trainee, Department of Ophthalmology, Assam Medical College & Hospital, Dibrugarh, Assam, India., Lahkar Gariyashee , Gogoi R.N. ,   Associate Professor, Department of Ophthalmology, Assam Medical College & Hospital, Dibrugarh, Assam, India.
Published: March 2023

We describe three cases of adherent leucoma with cataract who had unaided vision of hand movement close to face and were managed with relatively rare one step Triple procedure involving penetrating Keratoplasty, Extra-Capsular Cataract Extraction and IOL implantation(PKP-ECCE-PCIOL). Patients showed encouraging post-operative results, thereby providing impetus to study the role of this procedure in patients who are practically bilaterally blind in providing useful vision.
DESIGN OF SMALLHOLDER FARMERS PARTNERSHIP MODEL AND FINANCIAL ANALYSIS WITH THE CONCEPT OF CREATING SHARED VALUE
Authors:   Department of Industrial Engineering, Faculty of Engineering and Computer Science, Indraprasta PGRI University, Jakarta, Indonesia., Suhendar Endang , Sukardi Sukardi ,   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia., Romli Muhammad ,   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia., Raharja Sapta ,   Department of Agroindustrial Engineering, IPB University, Dramaga, PO Box 220, Bogor, West Jaya, Indonesia.
Published: March 2023

Approximately 90% of Indonesias local beef supply is supplied by smallholder farmers who practice traditional and inefficient management. PT X is one of the companies that has assisted smallholder farmers through a partnership system that includes banks and insurance companies. However, smallholder farmers continue to require assistance due to complex requirements, such as interest charges. This study aims to measure and analyze the performance of partnerships at PT X, design an interest-free Creating Shared Value (CSV) partnership model, and run financial analysis simulations, namely Net Present Value and Benefit-Cost Ratio. Meanwhile, the importance-performance analysis is used in the design of the partnership model. The studys findings indicate that the PT X partnership performs quite well. However, eight performance variables must be improved and used to create CSV partnerships. All partnership patterns applied using the interest-free CSV concept produce the largest NPV and BCR values. Even in the breeding partnership pattern, the highest NPV value was IDR 3,430,000, and the largest Net BCR was 1.26%. Thus the partnership with the CSV concept can be implemented and provide mutual benefits to partner smallholder farmers and PT X by creating shared value. Further research is recommended to avoid the risk of moral hazard and partnership failure.
BIOLOGY IN JAINISM: A REVIEW
Authors:   Professor, Department of Zoology Maharanis Science College For Women, Maharani Cluster University, Palace Road, Bengaluru-01., B.K. Meera , V. Latha ,   Associate Professor, Department of Zoology, Maharanis Science College For Women, Maharani Cluster University, Palace Road, Bengaluru-01.
Published: March 2023

The history of science is not just a chronological description of events of scientific discovery but it is a story of an ongoing process of the interaction of science and society.It is a story of how socio-economic conditions of a given society necessitate particular inventions and innovations. These processes are neither time restricted nor space restricted. In the sense, they are of universal applied value. In this context, it is worth remembering that, the rich heritage of India, comprises science and technology too, though only few people are aware of this. However, only recently, since few decades, people are attempting to popularize the scientific facts hidden latent in ancient works which have been mostly written in either Sanskrit or Halegannada. The present paper attempts to disclose the various aspects of biology that have appeared in major works of JAINISM. Eight major works pertaining to Jainism basically were studied in depth to gather information relevant to biological sciences and complied to obtain a comprehensive report.
COUNTERFEIT PRODUCT DETECTION SYSTEM USING GRAPHICAL QRCODE IN BLOCKCHAIN
Authors:   Information TechnologySri Sairam Institute of TechnologyChennai-600044., Brindha Devi V. , P. Mercy ,   Information TechnologySri Sairam Institute of TechnologyChennai-600044., R. Madhubala ,   Information TechnologySri Sairam Institute of TechnologyChennai-600044.
Published: March 2023

Nowadays people buy products through online and even from shops, but could not distinguish which is a counterfeit product and which is a genuine product. There are many famous companies whose product is duplicated and made some changes and are sold in the market, where even the manufacturer get confused with the duplicate product. The customer buys the product and comes to a bad opinion about the company which is completely a negative part on the side of the manufacturer and the seller who sells the product. So in order to overcome this, manufacturers need to generate a graphical Quick response code that will be linked with the blockchain. When there is a usage of a normal Quick response code (QR code) which has a combination of black and white colors it will be easy for the hackers to duplicate the data. So manufacturers need to include a graphical-based QR code where hackers could not duplicate the product which may lead to ink smearing. When they link the Graphical QR code to the blockchain all the data will be stored in the form of blocks and could not change any of the data which is stored in blocks, on the customer side where they could scan the graphical QR code and find whether the Product is genuine or not. For each transaction in the blockchain, aspecific hash value will be generated and this hash when the customer scan needs to match the hash value what the manufacturer who added the block for the product. In this way, the counterfeit product could be eradicated from the market.