bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term results of simultaneous hybrid ablation of therapy-resistant atrial fibrillation
Authors: Baimbetov A , Bizhanov K , Yakupova I , Bairamov B , Medeubekov U , Madyarov V
Published: November 2020

Background

A hybrid technique using thoracoscopic epicardial and standard endocardial ablation of atrial fibrillation (AF) is a strategy used to treat AF patients with therapy-resistant symptomatic AF. We conducted comparative study of efficacy and safety of simultaneous hybrid ablation in patients with non-paroxysmal forms of AF and evaluated the factors that determine success and quality of life.

Methods

The study included 56 consecutive patients who underwent simultaneous hybrid ablation. First, epicardial ablation was performed using thoracoscopic access: to isolate the pulmonary veins and the posterior wall of the left atrium. After this, an endocardial electrophysiological assessment was carried out from the pulmonary veins to the left atrium and additional endocardial ablation was performed, where necessary. The next day, a loop ECG recorder was implanted subcutaneously in the thoracic region. Efficiency was evaluated using implanted loop ECG recorders. The average follow up was 24 months, the studied patients came to the clinic every 3 months to receive diagnostic reports from loop recorders. Recurrence was defined as AF, atrial flutter and other atrial tachycardia, recorded in reports of loop recorders lasting >30 sec during follow up period.

Results

Continuous follow up was carried out in 56 patients, the average age of which was 57±9 years. Of these, 39 (70%) men, 6 (10%) paroxysmal, 38 (68%) persistent and 12 (22%) long-standing persistent AF. Within 24 months of follow up, 45 (80%) maintened a sinus rhythm. Most recurrenses were atrial flutter (8/11 patients). Success was associated with factors such as left atrial size, patient age and duration of arrhythmia. Patients with paroxysmal AF had the highest success, patients with long-standing persistent AF had the least success. 5 (9%) patients had complications associated with the procedure. Quality of life after ablation improved in patients with sinus rhythm.

Conclusion

The efficiency of simultaneuous hybrid AF ablation was 80% for 24 months of continuous follow up period associated with the type of AF. Quality of life improved significantly, complications associated with the procedure occurred in 9%.

Funding Acknowledgement

Type of funding source: None
The predictor role of worsening renal function in patients with new onset atrial fibrillation on direct oral anticoagulant
Authors: Bartoli L , Angeli F , Stefanizzi A , Paolisso P , Bergamaschi L , Toniolo S , Donati F , D'Angelo E.C , Magnani I , Foa' A , Rinaldi A , Martignani C , Biffi M , Pizzi C , Galie' N
Published: November 2020

Background

Chronic kidney disease (CKD) is an important outcome predictor in patients with atrial fibrillation (AF). Moreover, renal function at baseline is used to guide oral anticoagulant (OA) selection and dosing at initial treatment. The prognostic role of worsening renal function (WRF) during treatment with direct oral anticoagulants (DOACS) has been poorly explored.

Purpose

To estimate the prognostic role of WRF in terms of major adverse cardiovascular events (MACEs) in a series of patients with newly diagnosed non-valvular AF (NVAF) treated with DOACs.

Methods

Among all patients with newly diagnosed NVAF and indication for OA between January 2017 and December 2018, we enrolled those treated with DOACs. Renal function at baseline and during follow-up was assessed with estimated glomerular filtration rates (eGFR). eGFR was calculated as a mean value of Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas. The hemorrhagic risk at baseline was estimated with the main available scores (HAS-BLED, ATRIA and ORBIT). WRF was defined as a decrease in eGFR of at least 20%. MACEs were evaluated according to the type of DOAC and the WRF. Major bleedings (MB) were defined according to the ISTH definition.

Results

The study population was constituted by 249 patients with newly diagnosed NVAF started on DOAC and followed for a median time of 14.1±8.6 months. Overall, WRF was observed in 58 cases (23.3%). Patients with WRF had significative higher rates of death (10.3% versus 3.1%, p=0.025) and MB (13.8% versus 4.7%, p=0.016). The incidence of bleeding events, acute coronary syndromes and stroke was not affected by WRF. Interestingly, CG formula better predicted the incidence of MB as compared to the other formulas (p=0.006). The type of DOAC did not significantly impact the observed renal impairment and had no effect on the occurrence of MACEs in patients showing WRF. The predictors of WRF were found to be age, female sex, low hemoglobin level and left ventricle end telediastolic volume. At multivariate analysis, WRF was identified as an independent predictor of MB (OR 3.1, 95% C.I, 1.12–8.58), regardless of the baseline bleeding risk.

Conclusion

This is the first prospective study to evaluate the impact of worsening renal function on cardiovascular events in patients with atrial fibrillation treated with DOACs. A significant WRF emerged as an independent predictor of death and MB. The specific DOAC did not affect either the entity of worsening renal function or the incidence of cardiovascular events.

Funding Acknowledgement

Type of funding source: None
Is there a role for half-dose anticoagulation in atrial fibrillation? Randomized comparison of 2 doses of edoxaban in 14,014 patients in ENGAGE AF-TIMI 48
Authors: Steffel J , Ruff C.T , Braunwald E , Park J.G , Murphy S , Antman E.M , Giugliano R.P
Published: November 2020

Background

In the phase 3 RCT ENGAGE AF-TIMI 48, both the higher-dose (HDER/edoxaban 60/30mg) and lower-dose edoxaban regimen (LDER/edoxaban 30/15mg) were non-inferior to well-managed warfarin for the prevention of stroke or systemic embolic events in patients with atrial fibrillation (AF). While LDER was associated with a 41% relative increase in ischemic stroke as compared to warfarin, LDER showed a larger relative reduction in bleeding events than HDER. An interaction tree analysis was performed to identify subgroups of patients likely to derive greater benefit from LDER vs. HDER based on a serious net outcome (SNO) that combines the most serious stroke and bleeding events: disabling/fatal ischemic stroke or life-threatening/fatal bleeding.

Methods and results

LDER (N=7002) had a higher risk for disabling/fatal ischemic stroke (HR 1.37, 95% CI 1.06–1.77; p=0.017), but fewer life-threatening/fatal bleeds (0.61 (0.44, 0.84), p=0.002) than HDER (N=7012). The SNO was similar with LDER vs HDER in the total population (0.95 (0.78–1.16), p=0.61). In the 30% of patients who had either malignancy or paroxysmal AF (Figure) the SNO was significantly lower with LDER vs HDER (HR 0.59 (0.40–0.86)), driven by large reductions in bleeding without an increase in ischemic stroke in this subgroup (figure). Meanwhile the remaining 70% of patients with neither malignancy nor paroxysmal AF tended to have a higher risk with LDER vs. HDER (HR 1.15 (0.91–1.46), P-interaction 0.003).

Conclusions

In our current post-hoc analysis we were able to demonstrate that the combined rate of serious stroke and bleeding events was similar in patients treated with LDER and HDER. Moreover, patients with a malignancy as well as those with paroxysmal AF derived a greater net benefit from LDER vs. HDER regarding serious AF-/anticoagulation-related outcome events. These results need to be viewed as hypothesis-generating which may, if confirmed, aid physicians in individualizing edoxaban dosing.

Funding Acknowledgement

Type of funding source: None
Clinical implications of assessment of apixaban levels in elderly atrial fibrillation patients: J-ELD AF Registry sub-cohort analysis
Authors: Suzuki S , Yamashita T , Akao M , Okumura K
Published: November 2020

Background

Randomized clinical trials demonstrated the efficacy and safety of apixaban in preventing stroke in patients with atrial fibrillation (AF). However, data on distribution of apixaban levels and their relationships with clinical outcomes are limited.

Purpose

To evaluate the distribution of blood apixaban concentration and its relationship with clinical outcomes.

Method

The J-ELD AF Registry is a large-scale, multicenter prospective observational study of Japanese non-valvular AF patients aged ≥75 years taking on-label dose (standard dose of 5 mg bid or reduced dose of 2.5 mg bid) of apixaban. Among the entire cohort (3,015 patients from 110 institutions), plasma apixaban levels at trough was measured by anti-Xa assay (Api-AXA) in 943 patients. The 943 patients were divided into 2 groups by the apixaban dose (standard dose [n=431] and reduced dose [n=512]) and each group was further divided into 2 groups with low and high Api-AXA levels compared with the median value.

Results

In patients with standard dose, the incidence rates (/100 person-years) of stroke or systemic embolism (1.48 and 1.99), bleeding requiring hospitalization (0.98 and 1.49), and total deaths (0.49 and 0.99) were comparable between low and high Api-AXA groups, respectively. In patients with reduced dose, although the incidence rates (/100 person-years) of stroke or systemic embolism (0.84 and 1.68) were comparable, bleeding requiring hospitalization (0.42 and 4.64), and total deaths (2.52 and 6.65) were significantly higher in high Api-AXA group than in low Api-AXA group. Multivariable Cox regression analysis revealed that in patients with reduced dose, high Api-AXA level was independently associated with bleeding requiring hospitalization (HR 12.12, 95% CI: 1.56–94.22, P=0.017) and insignificantly with total deaths (HR 2.15, 95% CI: 0.83–5.55, P=0.116).

Conclusions

High trough apixaban level in patients with standard dose was not associated with adverse events, while that in patients with reduced dose was associated with bleeding requiring hospitalization and total deaths. Measurement of apixaban levels may be informative in elderly patients indicated for reduced dose possibly with the intent of risk stratification and decision making.

Funding Acknowledgement

Type of funding source: Other. Main funding source(s): Bristol-Myers Squibb K.K.
Short coupling with high burden of atrial ectopy in twenty-four hour holter recording predicts recurrence of atrial arrhythmia after atrial fibrillation ablation
Authors: Okajima T , Imai H , Murase Y , Kano N , Ogawa Y , Kawaguchi K
Published: November 2020

Background

Atrial arrhythmia recurrence is experienced in up to 20% of patients after initially receiving a catheter ablation for atrial fibrillation (AF). Therefore, it is important to define predictors of atrial arrhythmia recurrence. Atrial ectopy (AE) with short coupling interval (S-AE) has been reported to be a trigger of AF. On the other hand, high burden of AE has been reported to be a useful predictor of atrial arrhythmia recurrences after AF ablation. Thus, the combination of the incidence of S-AE and AE burden during a 24-hour Holter recording could be a useful predictor of atrial arrhythmia recurrence after AF ablation.

Purpose

To investigate this hypothesis, we performed a retrospective case-controlled study.

Methods

We enrolled 180 patients who underwent their first catheter ablation procedure for AF and performed a 24-hour Holter recording between 90 to 365 days after their ablation procedure. Patients who performed an additional ablation procedure before the Holter recording were excluded. Finally, we analyzed 173 patients (age: 65±10 years, female: 28.3%, non-paroxysmal: 27.7%). The Holter recordings were analyzed by the same experienced technicians. We defined AE as a narrow QRS complex occurring >25% than prior R-R interval, and S-AE as AE occurring >55% earlier than expected. The relationship between the characteristics of AE during the Holter recording and atrial arrhythmia recurrences was investigated.

Results

The Holter recordings were performed at a median of 103 (IQR: 98–138) days after ablation. The median number of AE were 144 (IQR: 54–699) beats per day, and S-AE was recorded in 49 patients (28.3%). Forty-two patients (24.3%) had a recurrence of atrial arrhythmia during a median 488-day follow up period. Patients with S-AE had a recurrence of atrial arrhythmia more frequently than those without S-AE (44.9% vs 16.1%, p<0.001). We found the cut-off point of AE burden as 241 beats per day by the receiver operating characteristic curve with 74% sensitivity and 70% specificity to predict atrial arrhythmia recurrence. We divided the patients into four groups according to the presence or absence of S-AE and high AE burden. In the Kaplan-Meier analysis, patients with S-AE and high AE burden had the highest atrial arrhythmia recurrence rate (Log-rank test: p<0.001). In the Cox multivariate analysis, S-AE with high AE burden was an independent predictor of atrial arrhythmia recurrence (HR: 4.27, 95% CI: 2.32–7.85, p<0.001).

Conclusion

For AF patients who underwent their first catheter ablation, S-AE (>55% earlier than expected) with high AE burden (>241 beats per day) during the 24-hour Holter recording predicted recurrences of atrial arrhythmia. These results can help to develop follow-up strategies after AF ablation.

Funding Acknowledgement

Type of funding source: None
A comparison of rate control and rhythm control in tachycardia induced cardiomyopathy patients with persistent atrial flutter
Authors: Oka S , Kai T , Hoshino K , Watanabe K , Nakamura J , Abe M , Watanabe A
Published: November 2020

Background/Introduction

Tachycardia induced cardiomyopathy (TIC) is a potentially reversible dysfunction of the left ventricle (LV) caused by tachyarrhythmias. Early recognition of TIC and treatment of the culprit arrhythmia using pharmacological therapy or catheter ablation results in the recovery of LV function. For atrial flutter (AFL)-induced TIC, rhythm control strategy, such as catheter ablation has been recommended. On the other hand, the efficacy of rate control strategy has remained unclear due to the difficulty of control with arrhythmic medications. However, not all patients can take rhythm control treatments due to their backgrounds.

Purpose

The aim of this cohort study was to establish whether rate control strategy using β-blocker is as effective as invasive rhythm control strategy for the recovery of LV function in patients with TIC due to AFL.

Methods

We prospectively assessed 47 symptomatic non-ischaemic heart failure (HF) patients with left ventricular ejection fraction (LVEF) below 50% and suspected TIC induced by persistent AFL. Patients were divided into rhythm control strategy group (n=22, treatment: catheter ablation, electrical cardioversion) and rate control strategy group (n=25, treatment: bisoprolol). As a sub-group study, the rate control strategy group was divided into the strict rate control group (n=12, average heart rate below 80 bpm) and lenient rate control group (n=13, average heart rate below 110 bpm). The primary outcome was the recovery of LV function, defined as an increase of LVEF over 20% or to a value of 55% or greater after 6 months.

Results

There were no significant differences in baseline AFL heart rate, New York Heart Association class, LVEF, estimated glomerular filtration rate, and brain natriuretic peptide between the two groups. A greater proportion of patients who showed the recovery of LVEF after 6 months belonged to the rhythm control strategy group (90.9% vs. 52.0%, p=0.004). The cumulative incidence of HF re-hospitalization was significantly higher in the rate control strategy group than in the rhythm control strategy group (hazard ratio: 4.90, 95% CI: 1.06–22.69). As a result of sub-group study, LVEF recovery was greater in the strict rate control group compared to the lenient rate control group (75.0% vs. 30.8%, p=0.027)

Conclusion

Rate control strategy was significantly inferior to rhythm control strategy for the recovery of LVEF in TIC patients with persistent AFL. Rhythm control should be the first choice in the management of TIC with AFL, and strict rate control should be an alternative if rhythm control is not available.

Primary outcomes

Funding Acknowledgement

Type of funding source: None
Clinical risk predictors for bradycardia, supraventricular tachycardia and epilepsy necessitating therapy in patients with unexplained syncope monitored by insertable cardiac monitor
Authors: Onuki T , Shoji M , Kikuchi M , Asano T , Suzuki H , Tannno K , Shinke T
Published: November 2020

Background

Insertable cardiac monitors (ICMs) allow for lengthy monitoring of cardiac rhythm and improve diagnostic yield in patients with unexplained syncope. In most cardiac syncope cases, sick sinus syndrome, atrioventricular block, and paroxysmal supraventricular tachycardia (SVT) are detected using ICMs. On the other hand, epileptic seizures are sometimes diagnosed as unexplained syncope because in these situations, the loss of consciousness is a similar manifestation. Thus, the population of patients with unexplained syncope monitored by ICMs includes epileptic patients. Clinical risk factors for bradycardia, SVT and epilepsy that necessitate therapy in patients with unexplained syncope are not well known. If these risks can be clarified, clinicians could provide more specific targeted monitoring.

Purpose

We aimed to identify these predictors.

Methods

We retrospectively reviewed medical records of consecutive patients who received ICMs to monitor unexplained syncope in three medical facilities. We performed Cox's stepwise logistic regression analysis to identify significant independent risk factors for bradycardia, SVT, and epilepsy.

Results

One hundred thirty-two patients received ICMs to monitor unexplained syncope. During the 17-month follow-up period, 19 patients (10 patients had sick sinus syndrome and 9 had atrioventricular block) needed pacemaker for bradycardia; 8 patients (3 had atrial flutter, 4 had atrial tachycardia, and 1 had paroxysmal atrial fibrillation) needed catheter ablation for SVT; and 9 patients needed antiepileptic agents from the neurologist.Stepwise logistic regression analysis indicated that syncope during effort (odds ratio [OR] = 3.41; 95% confidence interval [CI], 1.21 to 9.6; p=0.02) was an independent risk factor for bradycardia. Palpitation before syncope (OR = 9.46; 95% CI, 1.78 to 50.10; p=0.008) and history of atrial fibrillation (OR = 10.1; 95% CI, 1.96 to 52.45; p=0.006) were identified as significant independent prognostic factors for SVT. Syncope while supine (OR = 11.7; 95% CI, 1.72 to 79.7; p=0.01) or driving (OR = 15.6; 95% CI, 2.10 to 115.3; p=0.007) was an independent factor for epileptic seizure.

Conclusions

ICMs are useful devices for diagnosing unexplained syncope. Palpitation, atrial fibrillation and syncope during effort were independent risk factors for bradycardia and for SVT. Syncope while supine or driving was an independent risk factor for epilepsy. We should carefully follow up of patients with these risk factors.

Funding Acknowledgement

Type of funding source: None
Pacing of the interventricular septum with His bundle engagement, unlike myocardial pacings of the right ventricle, does not lead to ventricular dyssynchrony, as assessed by ultra-high frequency ECG
Authors: Curila K , Jurak P , Karch J , Halamek J , Prochazkova R , Stros P , Plesinger F , Smisek R , Waldauf P , Susankova M , Herman D , Osmancik P , Widimsky P
Published: November 2020

Background

Nonselective pacing of the distal His bundle is practically just another way of right ventricular septal pacing. It leads to the concomitant activation of the His bundle and septal myocytes with unknown impact on ventricular synchrony. Ultra-high frequency ECG (UHF-ECG) is a novel tool for ventricular depolarization imaging.

Purpose

To describe ventricular depolarization patterns during nonselective pacing of a ventricular aspect of His bundle and myocardial captures from different locations in the right ventricle by using the UHF-ECG.

Methods

Consecutive patients with an indication for permanent pacing due to bradycardia were included. During pacemaker implantation, the pacing lead was temporarily placed in prespecified locations of the right ventricle (mid-septum, anterior, lateral wall, and the para-hisian area of the RV). When pacing from mentioned locations, myocardial activation time under each specific lead (Vd), and ventricular dyssynchrony (e-DYS) indexes were calculated from UHF-ECG maps, for each particular type of pacing. The demonstration of UHF-ECG maps during pacing from different locations of the right ventricle is shown in the figure.

Results

Two hundred and fifty UHF ECG recordings were performed in forty-six patients. The calculated mean e-DYS parameter was significantly shorter during non-selective capture of the distal His bundle (14±8 ms) compared to each of myocardial captures of the right ventricle (pure myocardial para-hisian; 35±12 ms, mid-septal; 28±11 ms, anterior wall; 51±16 ms and lateral wall; 62±19 ms (p<0.001). The Vd was also shortest during non-selective capture of the distal His bundle (39±5 ms) compared to each of the others (pure myocardial para-hisian; 52±11 ms, RV mid-septal; 57±11 ms, RV anterior wall; 68±12 ms and RV lateral wall pacing; 85±14 ms (p<0.001).

Conclusion

Pacing of the basal interventricular septum with the engagement of the His bundle produced a superior depolarization pattern in both heart ventricles compared to other types of right ventricular myocardial capture, as assessed using UHF-ECG.

Figure 1. Examples of UHF-ECG depolarization maps of different types of ventricular activation in the same patient.

Funding Acknowledgement

Type of funding source: Public Institution(s). Main funding source(s): Charles University in Prague
Novel plasma biomarkers in arrhythmogenic cardiomyopathy: the role of ST2 and GDF-15 in predicting biventricular involvement
Authors: Akdis D , Chen L , Saguner A.M , Zhang N , Gawinecka J , Saleh L , Von Eckardstein A , Ren J , Matter C , Hu Z , Ruschitzka F , Chen X , Brunckhorst C , Song J , Duru F
Published: November 2020

Background

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease characterized by fibrofatty replacement of the myocardium and ventricular arrhythmias. Biventricular (BiV) involvement in ARVC may lead to heart failure.

Purpose

This study aimed to investigate the role of novel plasma biomarkers soluble (s)ST2, Galectin-3 (Gal-3) and GDF-15 in predicting BiV involvement and adverse outcomes in ARVC patients.

Methods

ARVC patients from two independent cohorts were studied. 108 patients were included from the discovery cohort and 47 patients were included from a second validation cohort. All patients had a definite ARVC diagnosis at time of blood withdrawal. sST2, Gal-3 and GDF-15 were independently correlated with NT-proBNP, left ventricular (LV) ejection fraction, late gadolinium enhancement by cardiac magnetic resonance (CMR) imaging and clinical outcome.

Results

ARVC patients with LV involvement had higher levels of sST2 and GDF-15 as compared to controls and patients with isolated right ventricular involvement. sST2 and GDF-15 significantly correlated to late gadolinium enhancement on CMR and also correlated to adverse heart failure outcomes. Gal-3 was elevated in ARVC patients with and without LV involvement as compared to controls. The combined use of the three biomarkers (NT-proBNP, sST2 and GDF-15) showed the best performance in predicting LV involvement in both the discovery and the validation cohort. Plasma drawn from coronary arteries and coronary sinus showed a transmyocardial elevation of sST2.

Conclusion

Our study shows that sST2 and GDF-15 may predict BiV involvement and the combined use of NT-proBNP, sST2 and GDF-15 shows the best prediction of LV involvement in ARVC. Transmyocardial elevation of sST2 suggests that this biomarker is produced by myocardial tissue in ARVC.

Funding Acknowledgement

Type of funding source: Foundation. Main funding source(s): Fuwai ARVC Program was supported by CAMS Innovation Fund for Medical Sciences and the National Natural Science Foundation of China, Zurich ARVC Program was supported by grants from the Schwyzer Foundation and Baugarten Foundation
Prognostic significance of negative T-waves and low amplitude T-waves in the general population
Authors: Holkeri A , Eranti A , Haukilahti M.A.E , Kerola T , Kentta T.V , Noponen K , Seppanen T , Rissanen H , Heliovaara M , Knekt P , Junttila M.J , Huikuri H.V , Aro A.L
Published: November 2020

Background

Negative T-waves are associated with sudden cardiac death (SCD) in the general population. Whether also low amplitude T-waves link to SCD risk in the general population is unknown.

Purpose

We investigated the prognostic significance of T-wave abnormalities in a general population cohort.

Methods

We evaluated the ECGs of 6584 Finnish general population subjects aged ≥30 years (mean age 51.2±13.9, 45.6% men) and classified them according to the T-wave morphology to 3 classes: 1) negative T-waves (negative T-wave with amplitude ≥0.1mV in ≥2 of the leads I, II, aVL, V4-V6), 2) low amplitude T-waves (negative or positive T-wave with amplitude <0.1mV and amplitude ratio of T-wave and R-wave ≤10% in ≥2 of the leads I, II, aVL, V4-V6), and 3) normal T-waves (not meeting the criteria for negative or low amplitude T-waves). Subjects were followed for 10 years for the occurrence of SCD, cardiac death, or death from any cause.

Results

A total of 239 subjects (3.5%) had negative T-waves, 869 (12.7%) low amplitude T-waves, and 5746 (83.8%) normal T-waves. The Table shows the baseline characteristics. Subjects with T-wave abnormalities were older and had more often cardiovascular morbidities than subjects with normal T-waves. Cardiovascular morbidities were most common in subjects with negative T-waves. After adjusting for multiple clinical factors, negative T-waves (HR 3.91; 95% CI 2.30–6.64) and low amplitude T-waves (HR 1.80; 95% CI 1.13–2.86) were associated with SCD, when compared to normal T-waves. Furthermore, both negative T-waves and low amplitude T-waves associated with cardiac death (HR 2.34; 95% CI 1.75–3.13 and HR 1.49; 95% CI 1.17–1.91, respectively) and death from any cause (HR 1.85; 95% CI 1.50–2.27 and HR 1.45; 95% CI 1.24–1.70, respectively). The Figure displays the survival plots for SCD according to T-wave group.

Conclusion

In addition to negative T-waves, low amplitude T-waves also associate with SCD risk in the general population. Focus should be also placed on these minor T-wave abnormalities in the future.

Kaplan-Meier plot

Funding Acknowledgement

Type of funding source: Foundation. Main funding source(s): Finnish Medical Foundation, Aarne Koskelo Foundation
Association of acute resuscitation and post-resuscitation survival with overall risk-standardized survival to discharge for in-hospital cardiac arrest
Authors: Girotra S , Nallamothu B , Tang Y , Chan P
Published: November 2020

Background

Although survival for in-hospital cardiac arrest (IHCA) varies markedly across sites, it remains unknown whether high survival at top-performing hospitals is due to high rates of acute resuscitation survival (i.e., achievement of return of spontaneous circulation [ROSC]), post-resuscitation survival (i.e., survival to discharge among patients who achieved ROSC), or both.

Methods

Using 2015–2018 Get With The Guidelines (GWTG)-Resuscitation data, we identified 290 hospitals (86,426 patients) with IHCA. For each hospital, we calculated overall risk-standardized survival (RSSR) to discharge for IHCA using a previously validated hierarchical regression model and categorized hospitals into quartiles based on that metric. Risk-adjusted rates of acute resuscitation survival (defined as return of spontaneous circulation for >20 minutes [ROSC]) and post-resuscitation survival (defined as the proportion of patients achieving ROSC who survived to hospital discharge) were also computed for each hospital. We examined the correlation between a hospital's overall RSSR with its risk-adjusted rate of acute resuscitation and post-resuscitation survival.

Results

Among study hospitals, the median RSSR was 25.1% (inter-quartile range [IQR]: 21.9%–27.7%). The median risk-adjusted rate of acute resuscitation survival was 72.4% (IQR: 67.9%–76.9%) and post-resuscitation survival was 34.0% (IQR: 31.5%–37.7%). Hospital rates of RSSR were less strongly correlated with risk-adjusted rates of acute resuscitation survival (rho=0.50, P<0.001) than post-resuscitation survival (rho=0.90, P<0.001). Compared with hospitals in the lowest quartile of RSSR, hospitals in the highest quartile had substantially higher rates of acute resuscitation survival (Q4: 75.4% vs. Q1: 66.8%; P<0.001) and post-resuscitation survival (Q4: 40.3% vs. Q1: 28.7%; P<0.001). Notably, there was no correlation between hospital risk-adjusted rates of acute resuscitation survival and post-resuscitation survival (rho=0.09, P=0.11).

Conclusion

Hospital that excel in overall IHCA survival in general excel in either acute resuscitation or post-resuscitation care. As most hospital-based quality improvement initiatives largely focus on acute resuscitation survival, our findings suggest that efforts to strengthen post-resuscitation care may offer additional opportunities to improve IHCA survival.

Funding Acknowledgement

Type of funding source: Public Institution(s). Main funding source(s): NHLBI
Combined endocardial and epicardial ventricular tachycardia ablation for ischemic and nonischemic dilated cardiomyopathy
Authors: Nascimento Matos D , Adragao P , Pisani C , Hatanaka V , Freitas P , Costa F , Chokr M , Hardy C , Ferreira A.M , Carmo P , Laura S , Morgado F , Cavaco D , Mendes M , Scanavacca M
Published: November 2020

Background

Patients with ischemic (IHD) and nonischemic (NICM) dilated heart disease and reduced left ventricular ejection fraction are at increased risk of ventricular tachycardias (VTs) or sudden cardiac death. VT catheter ablation is an invasive treatment modality for antiarrhythmic drugs-resistant VT that reduces arrhythmic episodes, improves quality of life and improves survival in patients with electrical storm. Direct comparison of the outcomes from combined and non-combined endoepicardial ablations is limited by patient characteristics, follow-up durations, protocols heterogeneity and scarcity of randomized trials. We aim to investigate the long-term clinical outcomes of these 2 strategies in the IHD and NICM populations.

Methods

Multicentric observational registry including 316 consecutive patients who underwent combined (C-ABL) and non-combined (NC-ABL) endoepicardial ventricular tachycardia (VT) ablation for drug-resistant VT between January 2008 and July 2019. Chagas' disease patients were excluded. Primary and secondary efficacy endpoints were defined as VT-free survival and all-cause death after ablation. Safety outcomes were defined by 30-days mortality and procedure-related complications.

Results

Most of the patients were male (85%), with IHD (67%) and a mean age of 63±13 years. During a mean follow-up of 3±2 years, 117 (37%) patients had VT recurrence and 73 (23%) died. Multivariate survival analysis identified storm (ES) at presentation (HR=2.17; 95% CI 1.44–3.25), IHD (HR=0.53, 95% CI 0.36–0.78), left ventricular ejection fraction (LEVF) (HR=0.97, 95% CI 0.95–0.99), New York Heart Association (NYHA) functional class III or IV (HR=1.79, 95% CI 1.13–2.85) and C-ABL (HR=0.49, 95% CI 0.27–0.92) as independent predictors of VT recurrence. In 135 patients undergoing two or more ablation procedures only C-ABL (HR=0.36, 95% CI 0.17–0.80) and ES at presentation (HR=2.42, 95% CI 1.24–4.70) were independent predictors of arrhythmia recurrence. The independent predictors of all-cause mortality were ES (HR=2.17, 95% CI 1.33–3.54), LVEF (HR=0.95, 95% CI 0.92–0.98), age (HR=1.03, 95% CI 1.01–1.05), NYHA functional class III or IV (HR=2.04, 95% CI 1.12–3.73), and C-ABL (HR=0.22, 95% CI 0.05–0.91). The survival benefit was only seen in patients with a previous ablation (P for interaction=0.04) – Figure 1. Mortality at 30-days was similar between NC-ABL and C-ABL (4% vs. 2%, respectively, P=0.777), as was the complication rate (10.3% vs. 15.1% respectively, P=0.336).

Conclusion

A combined endo-epicardial approach appears to be associated with greater VT-free survival and overall survival in ischemic and nonischemic patients undergoing repeated VT catheter ablations. Both strategies seem equally safe.

Survival analysis for C-ABL vs NC-ABL

Funding Acknowledgement

Type of funding source: None
Electrograms guided his bundle pacing implant: moving from radiology to electrical signals
Authors: Zanon F , Marcantoni L , Pastore G , Baracca E , Picariello C , Lanza D , Maddalozzo A , Roncon L
Published: November 2020

Background

The standard technique to His Bundle Pacing (HBP) based on a fluoroscopic approach might be challenging and fluoro consuming. The electrical signals could lead to a precise and rapid lead implant, thus reducing the fluoroscopy time (FT) and X-ray dose.

Objective

To evaluate the feasibility, efficacy and safety of the electrogram-guided technique to obtain His Bundle pacing (HBP) with minimal or no fluoroscopy use.

Methods

Between October and December 2018, 41 consecutive patients with indication for pacing underwent HBP with the electrogram-guided approach.

Results

Successful HBP was obtained in 39/41 (95%) pts, which is the study population (mean age 78±10 years). S-HBP and NS-HBP were achieved in 23 (59%) and 16 (41%) pts, respectively. Final HBP lead position was achieved in 31/39 (79.4%) pts with zero fluoroscopy, only guided by the electrical signals. In the remaining 8 pts a minimal dose of fluoro (mean 8 sec) has been required to locate the His. Fluoroscopy has been routinely used to remove the sheath and to ensure the slack. The atrial lead has been implanted in a standard fashion. No difference was observed in the FT for HBP lead placement in patients with S-HBP and NS-HBP (mean 8.1±25 sec vs 7.5±20 sec, p=0.8; median value 0 sec vs 0 sec). Moreover, no significant differences were observed in the FT needed for the entire procedure, total Dose Area Product (DAP) and total procedural time among both S-HBP and NS-HBP. The His lead dislodgement occurred in 1 (2.6%) patient one day after the procedure.

Conclusion

HBP could be performed safely and efficiently using the electrograms, with minimal or no fluoroscopy. Fluoroscopy was required during sheath removal and atrial lead placement.

Funding Acknowledgement

Type of funding source: None
Development of machine learning models to predict response after cardiac resynchronization therapy
Authors: Liang Y , Ding R , Zhu S , Su Y , Ge J
Published: November 2020

Background

There have been few practical and precise tools to predict response after cardiac resynchronisation therapy (CRT).

Purpose

We intend to develop predictive models using machine learning (ML) approaches and easily available features prior to implantation.

Methods

The baseline features of 596 patients receiving CRT were retrospectively collected. Nine predictive models were established, including logistic regression (LR), Elastic Net (EN), lasso regression, ridge regression (Ridge), neural network, support vector machine (SVM), random forest, XGBoost and k-nearest neighbor. Sensitivity, specificity, precision, accuracy, F1, area under receiver operating characteristic curve (AU-ROC) and average precision of each model were evaluated, and AU-ROC was compared between each pair of ML models and further between ML models and the latest guidelines.

Results

Sensitivity was highest with SVM by 0.69, and specificity was highest with LR by 0.81. The models EN and Ridge showed the highest overall predictive power with an average AU-ROC of 0.77. Specifically, the Ridge model provided significant higher AU-ROC than any other model (all P<0.05). All ML models showed significant higher AU-ROC than those derived from the latest guidelines (all P<0.05). Additionally, the effect size analysis identified LBBB, LVESD, and history of PCI as the most crucial predictive features.

Conclusion

ML algorithms produced efficient predictive models for evaluation of response after CRT with features prior to implantation. Tools developed accordingly might improve selection of CRT candidates and reduce rate of non-response in the future.

ROC and PR curves of predictive models

Funding Acknowledgement

Type of funding source: None
Threshold stability using active fixation LV lead
Authors: Diaz Exposito A , Ruiz Salas A , Medina C , Barrera A , Alzueta J , Gomez Doblas J.J
Published: November 2020

Introduction

The proper functioning of the CRT devices depends on the correct positioning of the electrodes, sometimes being compromised by the absence of suitable epicardial veins, leads instability or unacceptable high thresholds, among other. In 2017, a novel quadripolar active fixation LV lead was released with an innovative helical mechanism that expands to attach the lead within the vessel.

Objectives

Study the impact of the active fixation LV lead on threshold stability and dislocations.

Methods

We included 127 consecutive patients undergoing CRT between September 2017 to December 2019 in one hospital. They were randomly assigned: 62p active fixation VI leads vs 65p standard VI leads. LV thresholds, capture losses and dislocations were collected at standard pacing checks (1 week, 2 months, 6 months).

Results

The mean age of the sample was 73,9±8,4 years. 75% patients were male and 48,4% suffered ischemic cardiomyopathy. The two groups were similar according to this variables. 5 (7.7%) dislocations were reported in the control group against 2 (3.2%) in the active fixation group (n.s). The mean threshold (V) at the moment of the implant was 1,4 in the active fixation vs 1,41 in the standard LV leads; at the first visit 1,55 vs 1,99; at two months 1,59 vs 2,13 and at six months 1,74 vs 2,48.

The threshold stability is shown in Figure 1.

Conclusions

– The active fixation LV lead provides higher threshold stability than the conventional one.

– There is a non-significant tendency to reduce dislocations.

Figure 1

Funding Acknowledgement

Type of funding source: None
Impact of chronic sequential LV-RV pacing with cardiac resynchronization therapy for patients with narrower (<130 ms) QRS complexes following evaluation of acute myocardial strain characteristics
Authors: Kantharia B , Singh A , Karnik R , Shah A , Wu L , Narasimhan B
Published: November 2020

Background

Prior studies have shown acute improvement in myocardial strain patterns (SP) and strain rates (SR), left ventricular ejection fraction (LVEF), and long-term clinical improvement by Cardiac Resynchronization Therapy (CRT) preferential LV pacing. This relationship has not been studied in patients (pts) with narrower QRS.

Objectives

We aimed to evaluate myocardial speckle tracking SP and SR at different VV intervals in pts with narrow (<130 ms) and wide (>130 ms) QRS.

Methods

We assessed LVEF and speckle tracking myocardial SP and SR as per the American Society of Echocardiography (ASE) Dyssynchrony Writing Group methods in pts with CRT in acute settings at VV0, VV60 and LV-only pacing. For SP assessment, we used Bull's eye format display of the LV segments, and scores for SR, 2 = early stretch, late peak, 1= early stretch, early peak, and 0 = single peak at aortic closure.

Results

Total cohort of 271 pts; age 69.2±10.3 yrs (mean ± SD), male - 60%, divided into 2 groups; Gp A (QRS <130 ms, n=69) and Gp B (QRS >130 ms, n=202). QRS width and LVEF in Gp A and B were 120.1±12.3 ms and 152.1±12.9 ms, and 22.3±9.4% and 23.3±10.2% respectively. With VV0 increase in LVEF, 67±6.0% from baseline 22.3±9.4% was seen in Gp A compared to 43±6.5% from 23.3±10.2% in Gp B (p<0.01). With VV60 and LV-only pacing further rise in LVEF to 100.0±7.1% and 112.0±7.2% in Gp A and 80.2±8.0% and 93±8.1% in Gp B was seen. (Figure 1). Strain scores at different VV timings in both groups are shown in Table 1.

Conclusions

In pts with CRT, different VV timings show differences in acute myocardial speckle tracking SP and SR, and LVEF. These changes are markedly favorable with LV-only and sequential LV-RV pacing even in pts with narrower QRS. Our findings support chronic sequential LV-RV pacing programming in CRT pts with narrow QRS.

Figure 1

Funding Acknowledgement

Type of funding source: None
Clinic time required to manage cardiac implantable electronic device patients: a time and motion workflow evaluation
Authors: Biundo E , Burke A , Rosemas S , Lanctin D , Nicolle E
Published: November 2020

Background

The population with cardiac implantable electronic devices (CIEDs) is growing, creating workload for device clinics to manage these patients. However, the CIED follow-up workflow is poorly understood. This study sought to characterize the workflow and staff time for CIED patient management.

Methods

A time and motion workflow evaluation was performed in 6 U.S. CIED clinics, which manage an average of 4,217 patients. Each task involved in CIED management was repeatedly timed, including all manufacturers, during 1 business week at each clinic. Mean staff time for a remote transmission and an in-person visit were calculated, including all clinical and administrative (e.g: scheduling, documentation) activities related to the encounter. Annual staff time for follow-up of 1 patient was modeled using CIED transmission data for the 6 clinics, guidelines for CIED follow-up, and published literature.

Results

124 clinic visits and 1,374 remote monitoring activities were observed. Staff time required per remote transmission ranged from 12.1–13.4 minutes (depending on the CIED type), and time per visit was 43.4–51.0 minutes. Including all remote and in-person follow-ups, the estimated total staff time per year to manage one pacemaker, ICD, CRT, and ICM patient was 2.3, 2.4, 2.4, and 9.3 hours, respectively (Table 1).

Conclusion

CIED clinic workflow is complex and requires significant staff time. Remote monitoring is an efficient complement to in-office visits, allowing for continuous follow-up of patients. Future research should examine heterogeneity in clinic processes to identify the most efficient workflow.

Funding Acknowledgement

Type of funding source: Private company. Main funding source(s): Medtronic
Efficacy of adrenaline-packed dressing for bleeding control in patients undergoing cardiovascular implantable electronic device implantation; A Single-Center study
Authors: Anusonadisai K , Suwanagool A
Published: November 2020

Background

Each year, 1.65 million people around the world are implanted with Cardiac Implantable Electronic Devices [CIEDs], which our center, performed about 300–350 cases per year. These implantation process needs expertise and specializes in preventing the complication. Some complications, such as device-related bleeding complications (DRBCs) and pocket hematoma, especially in those patients receiving oral antithrombotic drugs before the surgery, should be preventable. Based on our observation of cases in the operation room, the wounds which were easily bleed can effectively create hemostasis by using adrenaline-packed dressing. The purpose of this study is to explore if the adrenaline pack dressing could reduce bleeding complications and reduce pocket hematoma in patients undergoing CIED implantation.

Purpose

To evaluate if adrenaline-packed dressing during CIED implantation can demonstrate a reduction in bleeding complication.

Methods

This is a single-center double-blind, randomized control study that included most of the patients undergoing CIED implantation in our center from June 2019 to Jan 2020. The patients will be randomized to adrenaline-packed dressing or matched control group. The protocol requires each patient to have a 2-weeks evaluation at the device clinic by two device-clinic staff. If DRBCs are detected, we used a caliper to measure the size in the largest dimension. Our primary outcome is the incidence of DRBCs at 2-weeks.

Results

There were 165 patients enrolled from June 2019 to Jan 2020. Mean age was 73 (female 52%), 24% on antiplatelet, 36% on anticoagulant. The pocket hematoma and ecchymosis at the 2-week was 15.8% and 15.2%, respectively. The DRBCs at 2-weeks was not significantly different between groups (22.6% vs. 33.3%; p=0.125). However, the next morning hematoma was significantly decreased in the adrenaline-packed dressing group (13.1% vs. 28.4%; p=0.015). The trend of subgroup analysis in the adrenaline pack dressing group was showing a reduction of DRBCs in patients who on anticoagulation therapy.

Conclusion

The adrenaline pack dressing appears to reduce early pocket hematoma significantly, but at two weeks, most of them were resolved and make no significant difference between groups.

Funding Acknowledgement

Type of funding source: None
Repeated lead extraction – the new challenge. Experience from 3207 TLE procedures
Authors: Kutarski A , Tulecki L , Czajkowski M , Tomkow K , Nowosielecka D , Stefanczyk P , Polewczyk A , Jachec W
Published: November 2020

Background

Transvenous lead extraction (TLE) is optimal option of management of lead-related problems. Usually the procedure has favourable long-term effect. Most of patients get the new or restored pacing system and risk of following lead-related problems may occur again. The knowledge about re-extraction procedures is limited.

Methods

In high volume centre during the last 15 years 3207 TLE procedures were performed and 1–6 leads (aver 1,65, with mean oldest implant duration 96,6 mth) were extracted using as first line non-powered mechanical tools. Other tools were used if necessary. We analysed data of first TLE procedures and repeated extractions.

Results

Are presented in the table. Re-extractions include 4,3% of all TLE procedures. Re-infection is less frequent reason for re-extraction (26,8%). Most re-extractions were performed because of dysfunction or damage of lead, which was newly implanted (56) or preserved during previous TLE (20). The last one indicates, that during TLE procedure it should be considered to replace all existing leads, not only these damaged or dysfunctional.

Conclusion

Re-extractions are safe procedures with very good results. Previously performed extraction is not a risk factor for another TLE procedure. Re-extraction should not be avoided in lead management strategy.

Table 1

Funding Acknowledgement

Type of funding source: None