bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposed guidelines for appropriate utilization of superficial radiation therapy in management of skin cancers. Zemtsov‐Cognetta criteria
Authors: Zemtsov Alexander , Cognetta Armand , Marvel John , Logan Ann
Published: March 2023

Objective

To develop appropriate use criteria (AUC) for the treatment of basal cell and squamous cell carcinoma by superficial radiation therapy (SRT) technique.

Material and Methods

Delphi‐type discussion of the experts.

Results

Presented in Figure 1.

Conclusion

These AUCs are in compliance both with the position statement of the American Academy of Dermatology (AAD) and the ASTRO Clinical Practice Guideline on this subject. It is further recommended that SRT will be only performed by either a dermatologist who is board certified in Mohs surgery (MDS) and who had adequate SRT training or by radiation oncologists. Hopefully, this publication will stimulate further discussion on this topic.
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
Authors: Bülck Cynthia , Nyström Elisabeth E. L. , Koudelka Tomas , Mannbar-Frahm Michael , Andresen Gerrit , Radhouani Mariem , Tran Florian , Scharfenberg Franka , Schrell Friederike , Armbrust Fred , Dahlke Eileen , Zhao Bei , Vervaeke Alex , Theilig Franziska , Rosenstiel Philip , Starkl Philipp , Rosshart Stephan P. , Fickenscher Helmut , Tholey Andreas , Hansson Gunnar C. , Becker-Pauly Christoph
Published: March 2023

The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form covalently linked heterodimers tethering meprin α to the plasma membrane, therefore presenting dual proteolytic activity in a unique enzyme complex. To unravel its function, we applied N-terminomics and identified galectin-3 as the major intestinal substrate for meprin α/β heterodimers. Galectin-3–deficient and meprin α/β double knockout mice show similar alterations in their microbiome in comparison to wild-type mice. We further demonstrate that meprin α/β heterodimers differentially process galectin-3 upon bacterial infection, in germ-free, conventionally housed (specific pathogen–free), or wildling mice, which in turn regulates the bacterial agglutination properties of galectin-3. Thus, the constitutive cleavage of galectin-3 by meprin α/β heterodimers may play a key role in colon host-microbiome homeostasis.
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication
Authors: Tsukamoto Yuta , Hiono Takahiro , Yamada Shintaro , Matsuno Keita , Faist Aileen , Claff Tobias , Hou Jianyu , Namasivayam Vigneshwaran , vom Hemdt Anja , Sugimoto Satoko , Ng Jin Ying , Christensen Maria H. , Tesfamariam Yonas M. , Wolter Steven , Juranek Stefan , Zillinger Thomas , Bauer Stefan , Hirokawa Takatsugu , Schmidt Florian I. , Kochs Georg , Shimojima Masayuki , Huang Yi-Shuian , Pichlmair Andreas , Kümmerer Beate M. , Sakoda Yoshihiro , Schlee Martin , Brunotte Linda , Müller Christa E. , Igarashi Manabu , Kato Hiroki
Published: March 2023

Orthomyxo- and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own transcription in a process called “cap snatching.” We report that RNA modification of the cap portion by host 2′-O-ribose methyltransferase 1 (MTr1) is essential for the initiation of influenza A and B virus replication, but not for other cap-snatching viruses. We identified with in silico compound screening and functional analysis a derivative of a natural product from
Streptomyces
, called trifluoromethyl-tubercidin (TFMT), that inhibits MTr1 through interaction at its
S
-adenosyl-
l
-methionine binding pocket to restrict influenza virus replication. Mechanistically, TFMT impairs the association of host cap RNAs with the viral polymerase basic protein 2 subunit in human lung explants and in vivo in mice. TFMT acts synergistically with approved anti-influenza drugs.
Probing matter with nonlinear spectroscopy
Authors: Leone Stephen R. , Neumark Daniel M.
Published: March 2023

Ultrafast nonlinear spectroscopy can unravel the dynamics of highly excited electronic states
Moiré photonics and optoelectronics
Authors: Du Luojun , Molas Maciej R. , Huang Zhiheng , Zhang Guangyu , Wang Feng , Sun Zhipei
Published: March 2023

Moiré superlattices, the artificial quantum materials, have provided a wide range of possibilities for the exploration of completely new physics and device architectures. In this Review, we focus on the recent progress on emerging moiré photonics and optoelectronics, including but not limited to moiré excitons, trions, and polaritons; resonantly hybridized excitons; reconstructed collective excitations; strong mid- and far-infrared photoresponses; terahertz single-photon detection; and symmetry-breaking optoelectronics. We also discuss the future opportunities and research directions in this field, such as developing advanced techniques to probe the emergent photonics and optoelectronics in an individual moiré supercell; exploring new ferroelectric, magnetic, and multiferroic moiré systems; and using external degrees of freedom to engineer moiré properties for exciting physics and potential technological innovations.
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
Authors: Shirai Taiichiro , Nakai Akiko , Ando Emiko , Fujimoto Jun , Leach Sarah , Arimori Takao , Higo Daisuke , van Eerden Floris J. , Tulyeu Janyerkye , Liu Yu-Chen , Okuzaki Daisuke , Murayama Masanori A. , Miyata Haruhiko , Nunomura Kazuto , Lin Bangzhong , Tani Akiyoshi , Kumanogoh Atsushi , Ikawa Masahito , Wing James B. , Standley Daron M. , Takagi Junichi , Suzuki Kazuhiro
Published: March 2023

Celastrol, a bioactive molecule extracted from the
Tripterygium wilfordii
plant, has been shown to exhibit anti-inflammatory properties. However, its mechanism of action has not been fully elucidated. Here, we show that celastrol suppresses humoral immune responses and autoimmunity by disabling a protein complex consisting of copper metabolism MURR1 domain–containing (COMMD) 3 and COMMD8 (COMMD3/8 complex), a signaling adaptor for chemoattractant receptors. Having demonstrated the involvement of the COMMD3/8 complex in a mouse model of rheumatoid arthritis, we identified celastrol as a compound that covalently bound to and dissociated the COMMD3/8 complex. Celastrol inhibited B cell migration, reduced antibody responses, and blocked arthritis progression, recapitulating deficiency of the COMMD3/8 complex. These effects of celastrol were abolished in mice expressing a celastrol-resistant mutant of the COMMD3/8 complex. These findings establish that celastrol exerts immunosuppressive activity by targeting the COMMD3/8 complex. Our study suggests that the COMMD3/8 complex is a potentially druggable target in autoimmune diseases and points to celastrol as a lead pharmacologic candidate in this capacity.
Impact of Population Aging on Asia’s Future Economic Growth, 2021–2050
Authors: PARK DONGHYUN , SHIN KWANHO
Published: March 2023

Developing Asia has grown faster than other parts of the world for decades. However, population aging is expected to pose significant headwinds to the region’s future economic growth. We update and enhance the analysis of Park and Shin (2012) to project the impact of population aging on developing Asia’s growth between 2021 and 2050. Our projections indicate that a demographic transition will have a substantial negative effect on the region’s future growth, but the effect varies across economies. Older economies will suffer a demographic tax, whereas younger economies will continue to enjoy a positive but declining demographic dividend.
PERCEPTION OF UNCERTAINTY AND GREEN INNOVATION: MACHINE LEARNING EVIDENCE FROM PUBLICLY LISTED FIRMS IN CHINA
Authors: YANG ZHEN , SU DONGWEI , XU SHULIN
Published: March 2023

Using a unique panel dataset consisting of 2997 Chinese manufacturing firms publicly listed in the A-share market between 2003 and 2020, we examine whether and to what extent a firm’s perception of uncertainty affects green innovation. After integrating textual analysis with a machine learning approach to measure perception of uncertainty, we find that a firm’s perception of environmental uncertainty negatively affects the number of green patents submitted or approved. The negative effect is weaker for firms followed by more professional analysts, operating in more competitive markets, or located in regions with better institutional settings. In addition, there is significant heterogeneity in the negative effect between non-state-owned versus state-owned firms as well as polluting versus non-polluting firms. The results are robust to different measures of green innovation and perception of uncertainty, and after addressing for potential endogeneity problem. Our study contributes to the literature on behavioral environmental economics by demonstrating that it is not only the environment uncertainty but also how firms perceive the uncertainty matters for green innovation and corporate social responsibility.
A Vision Comprehension-Driven Intelligent Recognition Approach for Actions of Tennis Players Based on Improved Convolution Neural Networks
Authors: Cai Zhiqiang , Zhang Zhixin , Lu Zhengdao
Published: March 2023

In this paper, we focus on two tasks: semantic segmentation and target detection in the visual semantic understanding of tennis sports images and we optimize the network structure to achieve a more complete location contour information mining of the target. In detail, we focus on a weakly supervised image semantic segmentation method based on null convolution pixel relations. To address the problem of incomplete pixel-level pseudo-labeling, we introduce a cavity convolution unit with multiple cavity rates and a self-attentive mechanism in the classification model to adaptively enhance the target regions and suppress other irrelevant regions while expanding the perceptual field to generate high-quality pixel-level pseudo-labeling and then train the semantic segmentation model. The final experimental results show that the hierarchical fusion algorithm proposed in this paper significantly outperforms other algorithms, and the overall classification accuracy of the tandem cavity neural network algorithm reaches 81% with good overall classification results. The recognition accuracy of static movements is higher than that of dynamic movements.
Reconstruction of an observationally constrained f(R,T) gravity model
Authors: Pradhan Anirudh , Goswami Gopikant , Beesham Aroonkumar
Published: March 2023

In this paper, an attempt is made to construct a Friedmann–Lemaitre–Robertson–Walker model in [Formula: see text] gravity with a perfect fluid that yields acceleration at late times. We take [Formula: see text] as [Formula: see text]. As in the [Formula: see text]CDM model, we take the matter to consist of two components, viz., [Formula: see text] and [Formula: see text] such that [Formula: see text]. The parameter [Formula: see text] is the matter density (baryons [Formula: see text] dark matter), and [Formula: see text] is the density associated with the Ricci scalar [Formula: see text] and the trace [Formula: see text] of the energy–momentum tensor, which we shall call dominant matter. We find that at present [Formula: see text] is dominant over [Formula: see text], and that the two are in the ratio 3:1–3:2 according to the three data sets: (i) 77 Hubble OHD data set, (ii) 580 SNIa supernova distance modulus data set and (iii) 66 pantheon SNIa data which include high red shift data in the range [Formula: see text]. We have also calculated the pressures and densities associated with the two matter densities, viz., [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text], respectively. It is also found that at present, [Formula: see text] is greater than [Formula: see text]. The negative dominant matter pressure [Formula: see text] creates acceleration in the universe. Our deceleration and snap parameters show a change from negative to positive, whereas the jerk parameter is always positive. This means that the universe is at present accelerating and in the past it was decelerating. State finder diagnostics indicate that our model is at present a dark energy quintessence model. The various other physical and geometric properties of the model are also discussed.
CORPORATE KEY CAPABILITIES, INNOVATION POLICY AND BUSINESS MODEL INNOVATION
Authors: CHEN CHIH-HUNG
Published: March 2023

While this research largely focuses on the context of sustainability and businesses model innovation (BMI) from different aspects of business, relatively few studies conduct in-depth analysis of what key capabilities a firm needs to achieve BMI. Meanwhile, innovation policy is accounting for issues relating to business development as a tool for improving competitiveness at macro level, but little has been discussed in what way it influences on firms. This study therefore first identifies corporate key capabilities that are required towards BMI, and then adopts innovation policy as a moderator to examine its indirect effect on BMI outcomes. A structured questionnaire was designed and 287 valid samples were collected from a population comprised of 948 listed companies on Taiwan Stock Exchange. Hypotheses were tested using the structural equation modelling (SEM) in SPSS for direct path analysis and Process for indirect effects. The outcome shows that three key capabilities, including Architecture, Reputation and Innovation, are crucial for a firm to accumulate over time in reaching BMI. The findings also indicate that innovation policy can be a significant external support for firms to accelerate BMI only if they develop three key capabilities simultaneously. The results of this study may assist public authorities and company managers with a useful guideline to make relevant policies and govern businesses.
Adaptive Weight Dynamic Butterfly Optimization Algorithm (ADBOA)-Based Feature Selection and Classifier for Chronic Kidney Disease (CKD) Diagnosis
Authors: Saroja T. , Kalpana Y.
Published: March 2023

Chronic Kidney Disease (CKD) are a universal issue for the well-being of people as they result in morbidities and deaths with the onset of additional diseases. Because there are no clear early symptoms of CKD, people frequently miss them. Timely identification of CKD allows individuals to acquire proper medications to prevent the development of the diseases. Machine learning technique (MLT) can strongly assist doctors in achieving this aim due to their rapid and precise determination capabilities. Many MLT encounter inappropriate features in most databases that might lower the classifier’s performance. Missing values are filled using K-Nearest Neighbor (KNN). Adaptive Weight Dynamic Butterfly Optimization Algorithm (AWDBOA) are nature-inspired feature selection (FS) techniques with good explorations, exploitations, convergences, and do not get trapped in local optimums. Operators used in Local Search Algorithm-Based Mutation (LSAM) and Butterfly Optimization Algorithm (BOA) which use diversity and generations of adaptive weights to features for enhancing FS are modified in this work. Simultaneously, an adaptive weight value is added for FS from the database. Following the identification of features, six MLT are used in classification tasks namely Logistic Regressions (LOG), Random Forest (RF), Support Vector Machine (SVM), KNNs, Naive Baye (NB), and Feed Forward Neural Network (FFNN). The CKD databases were retrieved from MLT repository of UCI (University of California, Irvine). Precision, Recall, F1-Score, Sensitivity, Specificity, and accuracy are compared to assess this work’s classification framework with existing approaches.
Dual Functional Si, N-Codoped Carbon Quantum Dots for Selective Fluorescence Sensing of Fe3+ and Visible-Light Photocatalysis of Organic Dyes
Authors: Wang Yun , Fu Guo , Li Chunxing , Meng Qin , Hu Xiaoxi
Published: March 2023

This work reports a simple, low cost and eco-friendly one-step hydrothermal method to obtain Si- and N-doped carbon quantum dots (Si-N-CQDs) using only citric acid and (3-aminopropyl) trimethoxysilane. These codoped Si-N-CQDs demonstrated 0D spherical morphology and an average size of [Formula: see text]2.54 nm as well as good solubility in water and high quantum yield equal to 14.3%. Fluorescence emission of these Si-N-CQDs was quenched selectively under the presence of [Formula: see text]. Based on this property, we developed a very sensitive sensor capable of detecting [Formula: see text] up to 400 [Formula: see text]M concentration with a 3.14 [Formula: see text]M detection limit. This sensor was used for [Formula: see text] detection in real tap and lake water and demonstrated satisfactory recovery equal to 102.3–108.0% and 103.5–108.5%, respectively. Photocatalytic activity of our Si-N-CQDs was demonstrated using methylene blue (MB) organic dye. The degradation rate of MB under visible light irradiation increased 2.7 times under the presence of Si-N-CQDs within 60 min. Such excellent performance was attributed to very efficient light absorption of Si-N-CQDs as well as excellent electron transfer and separation of photogenerated charge carriers.
Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments
Authors: Zercher Benjamin P. , Gozzo Theresa A. , Wageman AnneClaire , Bush Matthew F.
Published: March 2023

Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by creative innovation focused on both instrument architectures and how electric fields are applied. In this review, we focus on the application of high-resolution and multidimensional IM to biomolecular analyses, encompassing the fields of glycomics, lipidomics, peptidomics, and proteomics. We highlight selected research that demonstrates the application of the new IM toolkit to challenging biomolecular systems. Through our review of recently published literature, we outline the current strengths of respective technologies and perspectives for future applications.
Molecular Mechanisms of Transcription-Coupled Repair
Authors: Selby Christopher P. , Lindsey-Boltz Laura A. , Li Wentao , Sancar Aziz
Published: March 2023

Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes compared to those in nontranscribed regions of the genome, is defined as faster repair of the transcribed strand versus the nontranscribed strand in transcribed genes. The phenomenon, universal in model organisms including Escherichia coli, yeast, Arabidopsis, mice, and humans, involves a translocase that interacts with both RNA polymerase stalled at damage in the transcribed strand and nucleotide excision repair proteins to accelerate repair. Drosophila, a notable exception, exhibits TCR but lacks an obvious TCR translocase. Mutations inactivating TCR genes cause increased damage-induced mutagenesis in E. coli and severe neurological and UV sensitivity syndromes in humans. To date, only E. coli TCR has been reconstituted in vitro with purified proteins. Detailed investigations of TCR using genome-wide next-generation sequencing methods, cryo–electron microscopy, single-molecule analysis, and other approaches have revealed fascinating mechanisms.
The Activation Mechanism of the Insulin Receptor: A Structural Perspective
Authors: Choi Eunhee , Bai Xiao-Chen
Published: March 2023

The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human diseases, such as diabetes and cancers. The resolution revolution in cryo–electron microscopy has led to the determination of several structures of IR with different numbers of bound insulin molecules in recent years, which have tremendously improved our understanding of how IR is activated by insulin. Here, we review the insulin-induced activation mechanism of IR, including ( a) the detailed binding modes and functions of insulin at site 1 and site 2 and ( b) the insulin-induced structural transitions that are required for IR activation. We highlight several other key aspects of the activation and regulation of IR signaling and discuss the remaining gaps in our understanding of the IR activation mechanism and potential avenues of future research.
Progress in Sustainable Polymers from Biological Matter
Authors: Campbell Ian R. , Lin Meng-Yen , Iyer Hareesh , Parker Mallory , Fredricks Jeremy L. , Liao Kuotian , Jimenez Andrew M. , Grandgeorge Paul , Roumeli Eleftheria
Published: March 2023

The increasing consumption of nonrenewable materials urgently calls for the design and fabrication of sustainable alternatives. New generations of materials should be derived from renewable sources, processed using environmentally friendly methods, and designed considering their full life cycle, especially their end-of-life fate. Here, we review recent advances in developing sustainable polymers from biological matter (biomatter), including progress in the extraction and utilization of bioderived monomers and polymers, as well as the emergence of polymers produced directly from unprocessed biomatter (entire cells or tissues). We also discuss applications of sustainable polymers in bioplastics, biocomposites, and cementitious biomaterials, with emphasis on relating their performance to underlying fundamental mechanisms. Finally, we provide a future outlook for sustainable material development, highlighting the need for more accurate and accessible tools for assessing life-cycle impacts and socioeconomic challenges as this field advances.
From the Editor: Tell Them Now
Authors: Kelly Rob G.
Published: March 2023

All of us have been blessed with many people in our lives who raise us up when we stumble or inspire us to be better versions of ourselves. It makes little sense not to let them know that while they can appreciate it.
Neurocirculatory regulation and adaptations to exercise in chronic kidney disease
Authors: Sprick Justin D. , Jeong Jinhee , Sabino-Carvalho Jeann L. , Li Sabrina , Park Jeanie
Published: March 2023

Chronic kidney disease (CKD) is characterized by pronounced exercise intolerance and exaggerated blood pressure reactivity during exercise. Classic mechanisms of exercise intolerance in CKD have been extensively described previously and include uremic myopathy, chronic inflammation, malnutrition, and anemia. We contend that these classic mechanisms only partially explain the exercise intolerance experienced in CKD and that alterations in cardiovascular and autonomic regulation also play a key contributing role. The purpose of this review is to examine the physiological factors that contribute to neurocirculatory dysregulation during exercise and discuss the adaptations that result from regular exercise training in CKD. Key neurocirculatory mechanisms contributing to exercise intolerance in CKD include augmentation of the exercise pressor reflex, aberrations in neurocirculatory control, and increased neurovascular transduction. In addition, we highlight how some contributing factors may be improved through exercise training, with a specific focus on the sympathetic nervous system. Important areas for future work include understanding how the exercise prescription may best be optimized in CKD and how the beneficial effects of exercise training may extend to the brain.
Performance of Excavated Sulfur-Rich Soil Stabilized with Binder: A Field Study of Mixing Efficiency
Authors: Ziagharib Alaleh , Maurice Christian , Macsik Josef , Jia Qi , Laue Jan
Published: March 2023

In this study, a mixing procedure of sulfur-rich soil and cement-based binder to enhance the soil’s unconfined compressive strength (UCS) was tested in field conditions for geotechnical applications. The focus was to evaluate uniformity of industrial size soil-binder mixture, blended by existing method. This paper outlined sampling strategy and the number of samples needed for a valid uniformity evaluation. Moreover, this study emphasized the difference between field mixing and laboratory mixture preparation by comparing UCS of stabilized soil samples in the field and UCS of corresponding samples mixed and prepared in the laboratory environment. In the field, soil and cement were blended in two to four stages with 5% and 7% cement—the percentages being based on the soil’s dry weight under field conditions. Samples were taken from the field mixtures after each stage. Since the number of samples needed to be representative of mixture characteristics for large-scale mixing is not standardized, this field experiment included two phases. The first phase was dedicated to finding a sampling strategy for a large soil pile along with measuring UCS of collected samples. In the second phase, sample collection was conducted based on the results of sampling strategy from the first phase. In the laboratory, samples with percentages of binder similar to the amount of binder in the field were also prepared. Both field and laboratory samples were prepared using the tapping method in the laboratory for UCS test. Samples were cured under similar conditions for 28 days. The results showed that the uniformity of mixture improved after each additional mixing stage. In addition, while spots with low UCS were observed in the second mixing step, these spots were eliminated in the third mixing step, and results of the UCS tests were comparatively uniform. Moreover, comparison of the samples revealed that the UCS of the laboratory mixture is higher than that of the field mixture. This showed that even though the UCS is a good standard for comparing the strength of different soils stabilized with different percentages or types of binders in the field mixing, the actual strength of the stabilized mixtures under field circumstances is lower than that in laboratory prepared mixtures.
An Improved Structural Displacement Monitoring Approach by Acceleration-Aided Tilt Camera Measurement
Authors: Wu Tong , Tang Liang , Zhang Xiangyu , Liu Yijun , Li Xinyu , Zhou Zhixiang
Published: March 2023

Computer vision is becoming one of the most popular remote-sensing techniques and has been used widely in displacement monitoring and damage identification of in-service bridges. Nevertheless, several obstacles, including limited sampling rate, insufficient resolution for remote measurement, and error induced by camera tilting, restrict the application of vision-based approaches in structural health monitoring (SHM). The combination of a traditional SHM system and a modern remote-sensing technique can significantly improve the accuracy and reliability of the monitoring system. To make full use of data collected in the traditional SHM system and computer vision technique and overcome their shortcomings, we presented an improved bridge displacement estimation approach for SHM purposes by fusing camera-based and acceleration measurements. First, we estimated the scaling factor, which transfers pixel displacement to real displacement under tilt photogrammetry, by the acceleration reconstructed and camera-based displacements in the same frequency band without the actual size of the structure or the measurement parameters. Then, we extracted the low-frequency displacement from the vision-based measurement, and we fused the high-frequency displacement that was reconstructed from the acceleration measurement to achieve high-accuracy displacement estimation. The efficiency of this method was validated through dynamic load tests on a suspension model bridge in the laboratory and field tests on a highway and subway cable-stayed bridge.
Supplementary Materials and Methods, Figure Legends 1-3 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Authors: Perrotta Cristiana , Bizzozero Laura , Falcone Sestina , Rovere-Querini Patrizia , Prinetti Alessandro , Schuchman Edward H. , Sonnino Sandro , Manfredi Angelo A. , Clementi Emilio
Published: March 2023

Supplementary Materials and Methods, Figure Legends 1-3 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Supplementary Figure 3 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Authors: Perrotta Cristiana , Bizzozero Laura , Falcone Sestina , Rovere-Querini Patrizia , Prinetti Alessandro , Schuchman Edward H. , Sonnino Sandro , Manfredi Angelo A. , Clementi Emilio
Published: March 2023

Supplementary Figure 3 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Supplementary Figure 2 Legend from Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells
Authors: Kim Eun Hee , Sohn Seonghyang , Kwon Hyuk Jae , Kim Seung U. , Kim Min-Jung , Lee Su-Jae , Choi Kyeong Sook
Published: March 2023

Supplementary Figure 2 Legend from Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells
Supplementary Figure 1 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes
Authors: Koslowski Michael , Sahin Ugur , Mitnacht-Kraus Rita , Seitz Gerhard , Huber Christoph , Türeci Özlem
Published: March 2023

Supplementary Figure 1 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes
Supplementary Table 1 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Authors: Cantiani Lara , Manara Maria Cristina , Zucchini Cinzia , De Sanctis Paola , Zuntini Monia , Valvassori Luisa , Serra Massimo , Olivero Martina , Di Renzo Maria Flavia , Colombo Mario Paolo , Picci Piero , Scotlandi Katia
Published: March 2023

Supplementary Table 1 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Supplementary Figure 6 from Targeting the Nuclear Factor-κB Rescue Pathway Has Promising Future in Human Renal Cell Carcinoma Therapy
Authors: Sourbier Carole , Danilin Sabrina , Lindner Véronique , Steger Jacques , Rothhut Sylvie , Meyer Nicolas , Jacqmin Didier , Helwig Jean-Jacques , Lang Hervé , Massfelder Thierry
Published: March 2023

Supplementary Figure 6 from Targeting the Nuclear Factor-κB Rescue Pathway Has Promising Future in Human Renal Cell Carcinoma Therapy
Supplementary Table 2 from MicroRNA Signatures in Human Ovarian Cancer
Authors: Iorio Marilena V. , Visone Rosa , Di Leva Gianpiero , Donati Valentina , Petrocca Fabio , Casalini Patrizia , Taccioli Cristian , Volinia Stefano , Liu Chang-Gong , Alder Hansjuerg , Calin George A. , Ménard Sylvie , Croce Carlo M.
Published: March 2023

Supplementary Table 2 from MicroRNA Signatures in Human Ovarian Cancer
Supplementary Figure 1 from A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple Myeloma
Authors: Boylan Kristin L.M. , Gosse Mary A. , Staggs Sarah E. , Janz Siegfried , Grindle Suzanne , Kansas Geoffrey S. , Van Ness Brian G.
Published: March 2023

Supplementary Figure 1 from A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple Myeloma
Supplementary Figure 1 Legend from A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple Myeloma
Authors: Boylan Kristin L.M. , Gosse Mary A. , Staggs Sarah E. , Janz Siegfried , Grindle Suzanne , Kansas Geoffrey S. , Van Ness Brian G.
Published: March 2023

Supplementary Figure 1 Legend from A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple Myeloma
Supplementary Figure 2 from Reactive Oxygen Species Regulate Angiogenesis and Tumor Growth through Vascular Endothelial Growth Factor
Authors: Xia Chang , Meng Qiao , Liu Ling-Zhi , Rojanasakul Yongyut , Wang Xin-Ru , Jiang Bing-Hua
Published: March 2023

Supplementary Figure 2 from Reactive Oxygen Species Regulate Angiogenesis and Tumor Growth through Vascular Endothelial Growth Factor
Supplementary Figure Legends 1-4, Table 1 from Oncogenic BARD1 Isoforms Expressed in Gynecological Cancers
Authors: Li Lin , Ryser Stephan , Dizin Eva , Pils Dietmar , Krainer Michael , Jefford Charles Edward , Bertoni Francesco , Zeillinger Robert , Irminger-Finger Irmgard
Published: March 2023

Supplementary Figure Legends 1-4, Table 1 from Oncogenic BARD1 Isoforms Expressed in Gynecological Cancers
Supplementary Figure 3 from Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17β-Estradiol
Authors: Huang Yong , Fernandez Sandra V. , Goodwin Shirlean , Russo Patricia A. , Russo Irma H. , Sutter Thomas R. , Russo Jose
Published: March 2023

Supplementary Figure 3 from Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17β-Estradiol
Supplementary Figure 3 from DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells
Authors: Arlander Sonnet J.H. , Greene Bryan T. , Innes Cynthia L. , Paules Richard S.
Published: March 2023

Supplementary Figure 3 from DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells
Supplementary Figure 1 from DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells
Authors: Arlander Sonnet J.H. , Greene Bryan T. , Innes Cynthia L. , Paules Richard S.
Published: March 2023

Supplementary Figure 1 from DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells
Supplementary Figure 3 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
Authors: Trent Sally , Yang Chuanwei , Li Cuiqi , Lynch Mary , Schmidt Emmett V.
Published: March 2023

Supplementary Figure 3 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
Supplementary Figure 1 from Tumor Necrosis Factor α Mediates Homogeneous Distribution of Liposomes in Murine Melanoma that Contributes to a Better Tumor Response
Authors: Seynhaeve Ann L.B. , Hoving Saske , Schipper Debby , Vermeulen Cindy E. , aan de Wiel-Ambagtsheer Gisela , van Tiel Sandra T. , Eggermont Alexander M.M. , ten Hagen Timo L.M.
Published: March 2023

Supplementary Figure 1 from Tumor Necrosis Factor α Mediates Homogeneous Distribution of Liposomes in Murine Melanoma that Contributes to a Better Tumor Response
Supplementary Table 4 from Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel
Authors: Shen Lanlan , Kondo Yutaka , Ahmed Saira , Boumber Yanis , Konishi Kazuo , Guo Yi , Chen Xinli , Vilaythong Jill N. , Issa Jean-Pierre J.
Published: March 2023

Supplementary Table 4 from Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel
Supplementary Tables 1-7 from Genetic Determinants of Mitochondrial Response to Arsenic in Yeast Saccharomyces cerevisiae
Authors: Vujcic Marija , Shroff Meghna , Singh Keshav K.
Published: March 2023

Supplementary Tables 1-7 from Genetic Determinants of Mitochondrial Response to Arsenic in Yeast Saccharomyces cerevisiae
Supplementary Figure 4 from Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses
Authors: Fulci Giulia , Dmitrieva Nina , Gianni Davide , Fontana Elisabeth J. , Pan Xiaogang , Lu Yanhui , Kaufman Claire S. , Kaur Balveen , Lawler Sean E. , Lee Robert J. , Marsh Clay B. , Brat Daniel J. , van Rooijen Nico , Rachamimov Anat Stemmer , Hochberg Fred H. , Weissleder Ralph , Martuza Robert L. , Chiocca E. Antonio
Published: March 2023

Supplementary Figure 4 from Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses
Supplementary Figure Legends 1-3 from RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1-Deficient Breast Tumors
Authors: Martin Richard W. , Orelli Brian J. , Yamazoe Mitsuyoshi , Minn Andy J. , Takeda Shunichi , Bishop Douglas K.
Published: March 2023

Supplementary Figure Legends 1-3 from RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1-Deficient Breast Tumors
Supplementary Figure 3 from RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1-Deficient Breast Tumors
Authors: Martin Richard W. , Orelli Brian J. , Yamazoe Mitsuyoshi , Minn Andy J. , Takeda Shunichi , Bishop Douglas K.
Published: March 2023

Supplementary Figure 3 from RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1-Deficient Breast Tumors
Supplementary Figure 1 from Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin
Authors: Son Yong-gyu , Kim Eun Hee , Kim Jin Yeop , Kim Seung U. , Kwon Taeg Kyu , Yoon A-Rum , Yun Chae-Ok , Choi Kyeong Sook
Published: March 2023

Supplementary Figure 1 from Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin
Supplementary Information from Nuclear Factor-κB, an Unappreciated Tumor Suppressor
Authors: Chen Fei , Castranova Vince
Published: March 2023

Supplementary Information from Nuclear Factor-κB, an Unappreciated Tumor Suppressor
Supplementary Table 1, Figures 1-2 from EphB4 Overexpression in B16 Melanoma Cells Affects Arterial-Venous Patterning in Tumor Angiogenesis
Authors: Huang Xiaoyong , Yamada Yoshihiro , Kidoya Hiroyasu , Naito Hisamichi , Nagahama Yumi , Kong Lingyu , Katoh Shin-Ya , Li Weng-lin , Ueno Masaya , Takakura Nobuyuki
Published: March 2023

Supplementary Table 1, Figures 1-2 from EphB4 Overexpression in B16 Melanoma Cells Affects Arterial-Venous Patterning in Tumor Angiogenesis
Supplementary Figure 1 from Phosphatidylcholine-Specific Phospholipase C Activation in Epithelial Ovarian Cancer Cells
Authors: Spadaro Francesca , Ramoni Carlo , Mezzanzanica Delia , Miotti Silvia , Alberti Paola , Cecchetti Serena , Iorio Egidio , Dolo Vincenza , Canevari Silvana , Podo Franca
Published: March 2023

Supplementary Figure 1 from Phosphatidylcholine-Specific Phospholipase C Activation in Epithelial Ovarian Cancer Cells
Supplementary Figures 1-3 from Gene Expression Profiling of Breast, Prostate, and Glioma Cells following Single versus Fractionated Doses of Radiation
Authors: Tsai Mong-Hsun , Cook John A. , Chandramouli Gadisetti V.R. , DeGraff William , Yan Hailing , Zhao Shuping , Coleman C. Norman , Mitchell James B. , Chuang Eric Y.
Published: March 2023

Supplementary Figures 1-3 from Gene Expression Profiling of Breast, Prostate, and Glioma Cells following Single versus Fractionated Doses of Radiation
Supplementary Table 2 from Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion
Authors: Jagadeeswaran Ramasamy , Surawska Hanna , Krishnaswamy Soundararajan , Janamanchi Varalakshmi , Mackinnon A. Craig , Seiwert Tanguy Y. , Loganathan Sivakumar , Kanteti Rajani , Reichman Trevor , Nallasura Vidya , Schwartz Stuart , Faoro Leonardo , Wang Yi-Ching , Girard Luc , Tretiakova Maria S. , Ahmed Salman , Zumba Osvaldo , Soulii Lioubov , Bindokas Vytas P. , Szeto Livia L. , Gordon Gavin J. , Bueno Raphael , Sugarbaker David , Lingen Mark W. , Sattler Martin , Krausz Thomas , Vigneswaran Wickii , Natarajan Viswanathan , Minna John , Vokes Everett E. , Ferguson Mark K. , Husain Aliya N. , Salgia Ravi
Published: March 2023

Supplementary Table 2 from Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion
Supplementary Tables 1-2 from Multiple Myeloma Cell Killing by Depletion of the MET Receptor Tyrosine Kinase
Authors: Stellrecht Christine M. , Phillip Cornel J. , Cervantes-Gomez Fabiola , Gandhi Varsha
Published: March 2023

Supplementary Tables 1-2 from Multiple Myeloma Cell Killing by Depletion of the MET Receptor Tyrosine Kinase
Supplementary Table 1, Figures 1-7 from Jagged-1 and Notch3 Juxtacrine Loop Regulates Ovarian Tumor Growth and Adhesion
Authors: Choi Jung-Hye , Park Joon T. , Davidson Ben , Morin Patrice J. , Shih Ie-Ming , Wang Tian-Li
Published: March 2023

Supplementary Table 1, Figures 1-7 from Jagged-1 and Notch3 Juxtacrine Loop Regulates Ovarian Tumor Growth and Adhesion
Supplementary Table 1 from Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
Authors: Buck Elizabeth , Eyzaguirre Alexandra , Rosenfeld-Franklin Maryland , Thomson Stuart , Mulvihill Mark , Barr Sharon , Brown Eric , O'Connor Mathew , Yao Yan , Pachter Jonathan , Miglarese Mark , Epstein David , Iwata Kenneth K. , Haley John D. , Gibson Neil W. , Ji Qun-Sheng
Published: March 2023

Supplementary Table 1 from Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
Supplementary Figure Legends 1-3 from Extracellular Redox State Regulates Features Associated with Prostate Cancer Cell Invasion
Authors: Chaiswing Luksana , Zhong Weixiong , Cullen Joseph J. , Oberley Larry W. , Oberley Terry D.
Published: March 2023

Supplementary Figure Legends 1-3 from Extracellular Redox State Regulates Features Associated with Prostate Cancer Cell Invasion
Supplementary Figures 1-4 from Triggering Senescence Programs Suppresses Chk1 Kinase and Sensitizes Cells To Genotoxic Stresses
Authors: Gabai Vladimir L. , O'Callaghan-Sunol Cornelia , Meng Le , Sherman Michael Y. , Yaglom Julia
Published: March 2023

Supplementary Figures 1-4 from Triggering Senescence Programs Suppresses Chk1 Kinase and Sensitizes Cells To Genotoxic Stresses
Supplementary Figure 4 from An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells
Authors: Jiang Ping , Enomoto Atsushi , Jijiwa Mayumi , Kato Takuya , Hasegawa Taisaku , Ishida Maki , Sato Tomoko , Asai Naoya , Murakumo Yoshiki , Takahashi Masahide
Published: March 2023

Supplementary Figure 4 from An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells
Supplementary Figure 3 from An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells
Authors: Jiang Ping , Enomoto Atsushi , Jijiwa Mayumi , Kato Takuya , Hasegawa Taisaku , Ishida Maki , Sato Tomoko , Asai Naoya , Murakumo Yoshiki , Takahashi Masahide
Published: March 2023

Supplementary Figure 3 from An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells
Supplementary Table 3 from Genome-Wide Analysis of Aromatase Inhibitor-Resistant, Tamoxifen-Resistant, and Long-Term Estrogen-Deprived Cells Reveals a Role for Estrogen Receptor
Authors: Masri Selma , Phung Sheryl , Wang Xin , Wu Xiwei , Yuan Yate-Ching , Wagman Lawrence , Chen Shiuan
Published: March 2023

Supplementary Table 3 from Genome-Wide Analysis of Aromatase Inhibitor-Resistant, Tamoxifen-Resistant, and Long-Term Estrogen-Deprived Cells Reveals a Role for Estrogen Receptor
Supplementary Table 2 from Genome-Wide Analysis of Aromatase Inhibitor-Resistant, Tamoxifen-Resistant, and Long-Term Estrogen-Deprived Cells Reveals a Role for Estrogen Receptor
Authors: Masri Selma , Phung Sheryl , Wang Xin , Wu Xiwei , Yuan Yate-Ching , Wagman Lawrence , Chen Shiuan
Published: March 2023

Supplementary Table 2 from Genome-Wide Analysis of Aromatase Inhibitor-Resistant, Tamoxifen-Resistant, and Long-Term Estrogen-Deprived Cells Reveals a Role for Estrogen Receptor
Supplementary Data - Gene List from Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors
Authors: Martínez-Cruz Ana Belén , Santos Mirentxu , Lara M. Fernanda , Segrelles Carmen , Ruiz Sergio , Moral Marta , Lorz Corina , García-Escudero Ramón , Paramio Jesús M.
Published: March 2023

Supplementary Data - Gene List from Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors
Supplementary Figure 1 from Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients
Authors: Wang-Johanning Feng , Radvanyi Laszlo , Rycaj Kiera , Plummer Joshua B. , Yan Peisha , Sastry K. Jagannadha , Piyathilake Chandrika J. , Hunt Kelly K. , Johanning Gary L.
Published: March 2023

Supplementary Figure 1 from Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients
Supplementary Figure Legends 1-2 from Phenotype-Specific CpG Island Methylation Events in a Murine Model of Prostate Cancer
Authors: Camoriano Marta , Morey Kinney Shannon R. , Moser Michael T. , Foster Barbara A. , Mohler James L. , Trump Donald L. , Karpf Adam R. , Smiraglia Dominic J.
Published: March 2023

Supplementary Figure Legends 1-2 from Phenotype-Specific CpG Island Methylation Events in a Murine Model of Prostate Cancer
Supplementary Figure 2 from Phenotype-Specific CpG Island Methylation Events in a Murine Model of Prostate Cancer
Authors: Camoriano Marta , Morey Kinney Shannon R. , Moser Michael T. , Foster Barbara A. , Mohler James L. , Trump Donald L. , Karpf Adam R. , Smiraglia Dominic J.
Published: March 2023

Supplementary Figure 2 from Phenotype-Specific CpG Island Methylation Events in a Murine Model of Prostate Cancer
Supplementary Figure 1 from Endogenous Interleukin-4 Promotes Tumor Development by Increasing Tumor Cell Resistance to Apoptosis
Authors: Li Zhiguang , Jiang Jing , Wang Zibing , Zhang Jinhua , Xiao Mingjie , Wang Chunhui , Lu Yu , Qin Zhihai
Published: March 2023

Supplementary Figure 1 from Endogenous Interleukin-4 Promotes Tumor Development by Increasing Tumor Cell Resistance to Apoptosis
Supplementary Figure 2 from T-cadherin Supports Angiogenesis and Adiponectin Association with the Vasculature in a Mouse Mammary Tumor Model
Authors: Hebbard Lionel W. , Garlatti Michèle , Young Lawrence J.T. , Cardiff Robert D. , Oshima Robert G. , Ranscht Barbara
Published: March 2023

Supplementary Figure 2 from T-cadherin Supports Angiogenesis and Adiponectin Association with the Vasculature in a Mouse Mammary Tumor Model
Supplementary Materials and Methods from The Side Population of Ovarian Cancer Cells Is a Primary Target of IFN-α Antitumor Effects
Authors: Moserle Lidia , Indraccolo Stefano , Ghisi Margherita , Frasson Chiara , Fortunato Elena , Canevari Silvana , Miotti Silvia , Tosello Valeria , Zamarchi Rita , Corradin Alberto , Minuzzo Sonia , Rossi Elisabetta , Basso Giuseppe , Amadori Alberto
Published: March 2023

Supplementary Materials and Methods from The Side Population of Ovarian Cancer Cells Is a Primary Target of IFN-α Antitumor Effects
Supplementary Table 1 from Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer
Authors: O'Brien Carol , Cavet Guy , Pandita Ajay , Hu Xiaolan , Haydu Lauren , Mohan Sankar , Toy Karen , Rivers Celina Sanchez , Modrusan Zora , Amler Lukas C. , Lackner Mark R.
Published: March 2023

Supplementary Table 1 from Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer
Supplementary Figure 4 from Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer
Authors: O'Brien Carol , Cavet Guy , Pandita Ajay , Hu Xiaolan , Haydu Lauren , Mohan Sankar , Toy Karen , Rivers Celina Sanchez , Modrusan Zora , Amler Lukas C. , Lackner Mark R.
Published: March 2023

Supplementary Figure 4 from Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer