bluuebunny/crossref_metadata_2025 huggingface dataset:
Bosutinib-induced massive pleural effusion: Cross-intolerance with all tyrosine kinase inhibitors
Authors: Aslan Nevin Alayvaz , Hıncal Hande Oğul , Elver Özde , Erol Veysel , Güler Nil
Published: July 2022

Background

The discovery of tyrosine kinase inhibitors provided a breakthrough in the treatment of chronic myeloid leukemia. Nowadays, the management of tyrosine kinase inhibitor-related side effects is one of the important problems in chronic myeloid leukemia treatment. Grades 3–4 pulmonary toxicity; especially pleural effusion is mostly seen with dasatinib treatment but rarely seen with nilotinib and bosutinib. Development of cross-intolerance due to pleural effusion is not an expected situation. Pleural effusion related to tyrosine kinase inhibitors is mostly exudative in nature with abundant lymphocytes.

Case report

Massive pleural effusion developed in a 59-year-old male patient with chronic myeloid leukemia, who was being treated with bosutinib. In the past, the patient had experienced massive pleural effusion also with dasatinib and nilotinib. The evaluation for differential diagnosis of pleural effusion did not reveal any additional malignancy.

Management and outcome

After discontinuation of bosutinib and initiation of prednisolone, pleural effusion was totally resolved. Prednisolone was gradually discontinued and third-generation tyrosine kinase inhibitor ponatinib was started. After 12 months of follow-up, massive pleural effusion occurred again, leading to discontinuation of ponatinib.

Discussion

Cross-intolerance is an important problem in the tyrosine kinase inhibitor era. The significance of this case is the development of cross-intolerance to all second-generation tyrosine kinase inhibitors and furthermore to a third-generation tyrosine kinase inhibitor. Management strategies for pleural effusion and close follow-up are important.
Double guidewire technique (DGT): Optimising endovascular revision of juxta-anastomotic stenosis in AV-fistulae: A retrospective analysis
Authors: Pirozzi Nicola , Scrivano Jacopo , Andracchio Ludovica , Fazzari Loredana , Napoletano Antonello , Pirozzi Roberto
Published: July 2022

Background:

Arteriovenous fistula (AVF) is the preferred angioaccess for haemodialysis but suffers from a high stenosis rate, juxta-anastomotic stenosis (JAS) being the most frequent. Percutaneous transluminal angioplasty (PTA) of JAS would have some advantage (such as mini-invasive and vein sparing treatment), but higher recurrence rate is observed as compared to surgery. We report results of juxta anastomotic stenosis PTA using the ‘double guide technique’ (DGT) as described by Turmel-Rodrigues, in a selected cohort from our Vascular Access Centre.

Patients and methods:

From January to June 2018, 25 consecutive patients were treated by DGT. By means of retrograde access through the outflow vein by a 6 F introducer, two guide wires were navigated: one into proximal radial artery (GW1), the other into distal artery (GW2). GW2 was used to dilate juxta-anastomotic vein and anastomotic area with 6 mm high-pressure balloon, while by GW1 juxta-anastomotic artery was dilated with 4 mm semi-compliant balloon. Mean diameter of balloons were 6.7 and 4.1 mm for venous and arterial tract dilatation. Follow up was carried out up to 12 months. Prospectively collected data were analysed retrospectively.

Results:

One-year primary and secondary patency was 52% and 95% respectively. Recurrence rate was 0.56 procedure/pt/year. Mean access blood flow at 12 months was 830 ml/min.

Conclusion:

Double Guidewire Technique is an effective and minimally invasive procedure. By avoiding under dilation of JAS the recurrence rate resulted quite satisfactorily in our population.
How professionals deal with clients’ explicit objections to their advice
Authors: Bloch Steven , Antaki Charles
Published: July 2022

Previous literature on advice-resistance in medicine and welfare has tended to focus on patients’ or callers’ inexplicit resistance (minimal responses, silence and so on). But clients also raise explicit objections, which put up a firmer barrier against the advisor’s efforts. In a novel look at resistance, we show that one important distinction among objections is their epistemic domain: whether the client’s objection is in their own world (e.g. experiencing pain), or in the world of the practitioner (e.g. difficulties in making appointments). We show that the practitioner may try to manoeuvre the objection onto grounds where their own expertise will win the day, in five ways: conceding the objection’s validity as a preface to moving on; proposing a ‘work-around’ that effectively repeats the original advice; selecting an aspect of it that could be remediated; correcting the client’s understanding of the challenges of the advice; and stressing the urgency of the original course of action. We discuss the distinction between objections to solicited and unsolicited advice, and the role of objections in revealing, and affirming, a service-user’s personal life-world contingencies.
Fast Inverted Photoprotective o/w Emulsions Loaded With Dihydroquercetin and β-Carotene: An Innovative Approach to In Vitro Assessment of Antioxidant Activity in a Bioenvironment
Authors: Martić Radava , Kotur-Stevuljević Jelena , Malenović Anđelija , Ušjak Ljuboš , Petrović Silvana , Čalija Bojan , Milić Jela , Krajišnik Danina
Published: July 2022

Fast inverted, oil-in-water (o/w) emulsions, also known as SWitch-Oil-Phase (SWOP) emulsions, express the performances of both o/w and water-in-oil (w/o) emulsions during application to the skin, favoring their use as cosmetic carriers in sunscreen products. The objective of this study was to investigate the antioxidant potential (by 2 different methods) and the ultraviolet (UV) absorption ability of SWOP emulsion (S) with incorporated plant-based antioxidants dihydroquercetin (DHQ) and β-carotene (βC), using quercetin (Q) in a reference emulsion, in addition to the evaluation of their physicochemical properties and stability. A new biochemical extracellular model for in vitro assessment of antioxidative properties for the SWOP emulsions (S, SQ, SDHQ, and SDHQβC) was developed and compared with the results of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. The analyses were performed at 20 °C and 37 °C, and oxidative stress parameters were monitored and statistically analyzed. The sun protection factor (SPF) of the samples was determined in vitro. Q and DHQ incorporated into the SWOP emulsion exhibited a strong DPPH radical scavenging ability. Neither incorporated nor pure βC showed DPPH radical scavenging ability at the tested concentrations. Contrary to that, in the bioenvironment conditions, SDHQβC showed minor antioxidative effects increase and also a significant decrease in exogenous pro-oxidative effects, caused by pro-oxidant, when compared to SDHQ. The obtained SPFs of SDHQβC, SDHQ, and SQ were 5.19, 4.65, and 3.35, respectively. The physicochemical stability of the emulsions was satisfactory during 1 month storage. The presented results demonstrated that the SWOP emulsion is a suitable carrier for antioxidants with a photoprotective ability. The novel biochemical approach could be used in addition to DPPH assay with several advantages, relevant for the testing of antioxidant activity of potential active ingredients in cosmetic products.
Saccoite, Ca2Mn+32F(OH)8⋅0.5(SO4), a new, microporous mineral from the Kalahari Manganese Field, South Africa
Authors: Giester Gerald , Lengauer Christian L. , Chanmuang N. Chutimun , Topa Dan , Gutzmer Jens , von Bezing Karl-Ludwig
Published: July 2022

Saccoite, Ca2Mn3+2F(OH)8⋅0.5(SO4), is a new mineral found at the N'Chwaning III mine, Kalahari Manganese Field, Northern Cape Province, Republic of South Africa. It occurs as fillings of voids in hydrothermally altered manganese ore (comprising mostly of bixbyite and baryte). Further associated minor minerals are braunite, gypsum, chlorite, sturmanite and ettringite. Saccoite forms small needles, felted crystal masses or crusts. The new mineral is olive green, transparent, with white streak and vitreous lustre. No luminescence is observed. Saccoite is uniaxial (–) with refractive indices at 589(1) nm of ω = 1.705(5) and ɛ = 1.684(2). Pleochroism is distinct, i.e. bluish green (ω) and yellowish green (ɛ). The chemical composition was studied by means of an electron probe micro-analyser (EPMA) using wavelength-dispersive X-ray spectrometry (WDS). The empirical mineral formula is Ca2.06Mn3+1.78Cu0.10Mg0.07F0.97(OH)8.02(SO4)0.39. The unit-cell dimensions of saccoite (space group P4/ncc) are a = 12.834(3) Å, c = 5.622(2) Å, V = 926.0(4) Å3), and the calculated mass density is 2.73 g⋅cm–3. Saccoite exhibits a heteropolyhedral framework structure that is composed of edge- and corner sharing CaF2(OH)6 and M(OH)6 polyhedra (M = Mn3+ and Cu2+) with large channels along [001], which host disordered and only partially occupied groups, especially SO42–. The hydrogen atoms of the OH groups point into the channel to form hydrogen bonds with the channel anions. Ca–F distances are ~2.3 Å, the Ca–OH distances in the range of 2.44–2.58 Ǻ, and the M(OH)6 octahedron is strongly 4+2 Jahn-Teller distorted (4 × ~1.92 Å, 2 × 2.27 Å). The F atom is tetrahedrally coordinated to calcium atoms. The strongest lines in the powder X-ray diffraction pattern [d in Å (relative intensity) (hkl)] are: 9.0735 (35) (110), 4.5370 (95) (220), 4.0644 (20) (310), 3.0105 (100) (321), 2.8117 (20) (002), 2.7242 (75) (411), 1.9755 (35) (611), and 1.8142 (20) (550).
Chromosome-scale assembly and annotation of the perennial ryegrass genome
Authors: Nagy Istvan , Veeckman Elisabeth , Liu Chang , Bel Michiel Van , Vandepoele Klaas , Jensen Christian Sig , Ruttink Tom , Asp Torben
Published: July 2022

Background

The availability of chromosome-scale genome assemblies is fundamentally important to advance genetics and breeding in crops, as well as for evolutionary and comparative genomics. The improvement of long-read sequencing technologies and the advent of optical mapping and chromosome conformation capture technologies in the last few years, significantly promoted the development of chromosome-scale genome assemblies of model plants and crop species. In grasses, chromosome-scale genome assemblies recently became available for cultivated and wild species of the Triticeae subfamily. Development of state-of-the-art genomic resources in species of the Poeae subfamily, which includes important crops like fescues and ryegrasses, is lagging behind the progress in the cereal species.

Results

Here, we report a new chromosome-scale genome sequence assembly for perennial ryegrass, obtained by combining PacBio long-read sequencing, Illumina short-read polishing, BioNano optical mapping and Hi-C scaffolding. More than 90% of the total genome size of perennial ryegrass (approximately 2.55 Gb) is covered by seven pseudo-chromosomes that show high levels of collinearity to the orthologous chromosomes of Triticeae species. The transposon fraction of perennial ryegrass was found to be relatively low, approximately 35% of the total genome content, which is less than half of the genome repeat content of cultivated cereal species. We predicted 54,629 high-confidence gene models, 10,287 long non-coding RNAs and a total of 8,393 short non-coding RNAs in the perennial ryegrass genome.

Conclusions

The new reference genome sequence and annotation presented here are valuable resources for comparative genomic studies in grasses, as well as for breeding applications and will expedite the development of productive varieties in perennial ryegrass and related species.
Analysis of related factors of scheduled ICU before primary hip arthroplasty
Authors: Sun Jianguang , Yang Yali , Feng Guilan , Liang Chuanxing , Ling Weiming , Liao Hongxin
Published: July 2022

Background

Methods for improving the safety of medical treatments for patients, reducing the occurrence of postoperative complications and optimizing medical resources for primary hip replacement are needed. Previous literature has mostly analysed the risk factors and constructed and models to predict a transfer to the ICU after surgery, and no reports on preoperative ICU reservations have been found. This study evaluated the risk factors for preoperative ICU reservation and considered the necessity of preoperative ICU reservations to optimize preoperative communication, enable a seamless transfer between the operating room and ICU, reduce postoperative complications and shorten hospital stays.

Methods

We extracted the data of 1488 patients who underwent hip replacement from the hospital case database from November 2017 to May 2021 and used the case–control test to divide the patients into the case group (scheduled ICU admission, 134 cases) and the control group (Not scheduled ICU admission, 213 cases). The general conditions of the patients before surgery, including sex, age, Charlson comorbidity index, laboratory test results, and anaesthesia methods, were collected and used as independent variables. The t test, rank sum test, and X2 test were used to analyse and identify significant factors with a P < 0.05. Then, these factors were entered into binary logistic regression analysis, and a ROC curve was used to test the efficacy of the regression model.

Results

In the data we collected, 134 patients were planned to be transferred to the ICU, and 213 patients were not transferred to the ICU. The two groups of data were analyzed by logistic regression. We defined the risk factors for preoperative ICU appointment in patients with primary hip arthroplasty, including age. (odds ratio (OR) 1.066, 95% (confidence interval) CI (1.039, 1.093), P < 0.001), general anesthesia ( (OR) 1.821, 95%CI (1.165, 2.845), P = 0.008), preoperative C-reactive protein ((OR) 1.016, 95%CI (1.010, 1.022), P < 0.05), preoperative alanine aminotransferase ((OR) 1.042, 95%CI ((1.016, 1.070)), P = 0.002). These were promoting factors for preoperative ICU appointment,and preoperative albumin ((OR) 0.0839, 95%CI (0.792, 0.889)), P < 0.05) was a protective factor for ICU appointment.

Conclusion

For patients requiring primary hip replacement. Age, general anesthesia, preoperative C-reactive protein, preoperative alanine aminotransferase and preoperative albumin are the key points of our preoperative assessment. Paying attention to the changes of these indicators will help surgeons assess the patient's condition and contact the ICU in advance.These data can be fully understood by the patients' families, reduce the unnecessary use of medical resources, and optimize perioperative management.
Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals
Authors: Batchi-Bouyou Armel Landry , Djontu Jean Claude , Vouvoungui Jeannhey Christevy , Mfoutou Mapanguy Claujens Chastel , Lobaloba Ingoba Line , Mougany Jiré Séphora , Boumpoutou Kamal Rauchelvy , Diafouka-kietela Steve , Ampa Raoul , Ntoumi Francine
Published: July 2022

Background

Assessing immune responses after vaccination is part of the evaluation package of vaccine effectiveness in the real world. Regarding SARS-CoV-2, neutralizing antibody levels has been shown to be a good indicator of antibody immune response boosting. So far, limited data have been reported from Africa including in Central Africa. The objective of this study was to provide data on anti-S1 spike total IgG and neutralizing antibodies in vaccinated and non-vaccinated including naturally infected Congolese population during B.1.214.1 and B.1.617.2 variant waves.

Methods

Recruited patients were divided into 4 groups: (1) Naturally infected by the B.1.214.1 variant on January 2021 and followed up until September 2021. These patients have been vaccinated at month 07 and then followed up for 2 months post vaccination; (2) Naturally infected by the B.1.617.2 variant from June 2021; (3) unvaccinated SARS-CoV-2 individuals with no history of prior SARS-CoV-2 infection; (4) fully vaccinated individuals with sinopharm/BBIP-CorV or Janssen/Ad26.COV2.S. SARS-CoV-2 was detected by qRT-PCR and sequenced using Next-Generation Sequencing. ELISA method was used for detecting IgG, and neutralizing Antibody against SARS-CoV-2 antigens using commercial neutralizing assay.

Results

Individuals infected by the B.1214.1 variant elicited consistently high IgG titers at 02, 03 and 06 months. Two months post vaccination with BBIP-CorV, participants showed a significant increase by × 2.5 fold (p < 0.0001) of total IgG and X1.5 fold for neutralizing antibody capacity. This study showed that natural infection with B1.617.2 (delta) variant was more immunogenic compared to those being infected with B1.214.2 variant.

We found a significantly higher concentration in anti-SARS-CoV-2 IgG (p < 0.0002) and antibodies neutralization capacity (P < 0.0001) in fully vaccinated compared to unvaccinated participants. Two months post vaccination, individuals who received Janssen/Ad26.COV2.S presented higher (p = 0.01) total IgG to spike protein compared to BBIP-CorV.

Conclusion

Both natural infection and vaccination with BBIP-CorV and Janssen/Ad26.COV2.S induced antibody response in Congolese population. In addition, Janssen/Ad26.COV2.S was more immunogenic than Sinopharm/BBIP-CorV. There is a need to investigate the duration of these antibodies both in previously infected and naive vaccinated Congolese to allow public heath stakeholders to make evidence-based decision on vaccine schedule for the Congolese population.
A novel oppositional binary crow search algorithm with optimal machine learning based postpartum hemorrhage prediction model
Authors: Krishnamoorthy Sujatha , Liu Yihang , Liu Kun
Published: July 2022

Postpartum hemorrhage (PPH) is an obstetric emergency instigated by excessive blood loss which occurs frequently after the delivery. The PPH can result in volume depletion, hypovolemic shock, and anemia. This is particular condition is considered a major cause of maternal deaths around the globe. Presently, physicians utilize visual examination for calculating blood and fluid loss during delivery. Since the classical methods depend on expert knowledge and are inaccurate, automated machine learning based PPH diagnosis models are essential. In regard to this aspect, this study introduces an efficient oppositional binary crow search algorithm (OBCSA) with an optimal stacked auto encoder (OSAE) model, called OBCSA-OSAE for PPH prediction. The goal of the proposed OBCSA-OSAE technique is to detect and classify the presence or absence of PPH. The OBCSA-OSAE technique involves the design of OBCSA based feature selection (FS) methods to elect an optimum feature subset. Additionally, the OSAE based classification model is developed to include an effective parameter adjustment process utilizing Equilibrium Optimizer (EO). The performance validation of the OBCSA-OSAE technique is performed using the benchmark dataset. The experimental values pointed out the benefits of the OBCSA-OSAE approach in recent methods.
Preferences of women with a vulnerable health status towards nudging for adequate pregnancy preparation as investment in health of future generations: a qualitative study
Authors: Smith Sharissa M. , van der Kleij Rianne M. J. J. , Bais Babette , Schermer Maartje H. N. , Ismaili M’hamdi Hafez , Steegers-Theunissen Régine P. M.
Published: July 2022

Background

Women with a vulnerable health status, as determined by a low socioeconomic status and poor lifestyle behaviours, are at risk for adverse pregnancy outcomes. Offering tailored preconception lifestyle care can significantly help to improve pregnancy outcomes. We hypothesize that so-called ‘nudges’ can be a successful way of increasing the uptake of preconception lifestyle care. A nudge is a behavioural intervention that supports healthy choices by making them easier to choose. Nudging, however, raises many moral questions. Effectiveness and respect for autonomy are, among other criteria, required for a nudge to be morally permissible. In general, the target group knows best what they find permissible and what would motivate them to change their lifestyle. Therefore, this study – conducted in women with a vulnerable health status – aimed to identify their preferences towards a nudge, provided via a mobile application that aims to help them adopt healthy lifestyle behaviours by offering rewards. 

Methods

We conducted semi-structured interviews with twelve women with a vulnerable health status. A framework approach was used to analyse the data. A thematic content analysis was conducted on five themes: (1) “Usefulness of an app as an integral information source”, (2) “Permissibility and effects of offering rewards”, (3) “Preferences regarding content”, (4) “Preferences regarding type of rewards and system of allocation”, and (5) “Barriers”.

Results

Of the 12 participants, 11 deemed an app as integral information source concerning the preconception period useful. None of the participants objected to being nudged i.e., being rewarded for healthy behaviour. All participants stated that they would like the app to contain information on healthy nutrition and 8 participants wanted to know how to get pregnant quickly. Furthermore, participants stated that the freedom to choose the timing and content of the reward would increase the probability of successful behavioural change, and having to pay or contact a healthcare provider to access the app may prevent women using the app.

Conclusions

These insights into the preferences of women with a vulnerable health status towards nudging will inform the design of an effective app-based nudge. This may help to improve prepregnancy health as investment in health of current and future generations.
“Struggle at night – He doesn’t let me sleep sometimes”: a qualitative analysis of sleeping habits and routines of Hispanic toddlers at risk for obesity
Authors: Gray Megan J. , Vazquez Christian E. , Agnihotri Ojasvie
Published: July 2022

Background

Hispanic children face disproportionately higher risks for early life obesity and resultant comorbidities such as Type 2 diabetes and fatty liver disease. Sleep habits are modifiable behaviors that impact early childhood obesity; Hispanic infants have been shown to have less nighttime sleep compared to their white counterparts. Pediatricians often coach families on parents’ nighttime responsive feeding and longer child sleep duration as protective factors against early life obesity, but must understand the family context and potential barriers. This study aimed to discover the sleeping habits and routines of Hispanic toddlers at risk for obesity through the perspective of their mothers.

Methods

This qualitative study used a phenomenological approach. 14 Hispanic mothers were recruited from a Federally Qualified Health Center in Central Texas for qualitative interviews regarding their experience raising a small child. Children aged 6 to 18 months with child weight-for-length ratio ≥ 85% for age were approached for study involvement and consented during well child visits. Interviews occurred over several months during 2018–2019; NVivo software was used for analysis of qualitative themes. Two reviewers coded and used constant comparative methods to identify common themes.

Results

Mothers diverged from AAP recommended guidelines for infant and toddler feeding and sleep habits. Mothers shared their intentions and the real-life barriers to implementing recommended habits. Mothers discussed wanting to have their child sleep in a separate bed or room but not having the resources (i.e., financial, space) to do so. Additionally, mothers discussed knowing not to feed to soothe at night but couldn’t bring themselves to let their child cry if they knew feeding would soothe them. Co-sleeping, feeding to sleep, middle of the night feeding, and lack of structured sleep habits were common interview themes and potentially modifiable factors.

Conclusions

Pediatricians need to be sensitive to culture and the real-world needs of families to determine if best practices are “practical.” Themes from these parent interviews can inform tailored interventions for children at high risk of obesity. Interventions should promote responsive nighttime feeding and structured sleep, working with individual family logistics, to coach families towards optimal healthy environments and healthy child weight.
Profile of children with cerebral palsy at a tertiary hospital in eastern Nepal
Authors: Chaudhary Shipra , Bhatta Nisha Keshary , Poudel Prakash , Agrawal Jyoti , Kalawar Rosan Prasad Shah , Jayswal Jitendra Prasad
Published: July 2022

Background

The clinical spectrum of Cerebral palsy (CP) can differ in various places depending upon knowledge of the people and resources for prevention, diagnosis and management. Although studied extensively in high-resource countries, adequate data related to CP from resource-constraint settings are lacking. This study aims to describe the profile of children with CP at a tertiary care center in eastern Nepal.

Methods

This was a hospital-based cross-sectional descriptive study done from 2017 to 2018. Children 6 months to 15 years who presented with CP were enrolled and their clinical details recorded and described.

Results

Amongst 110 children with CP, 74.54% were male. Majority (76.36%) were 5 years or below with the median age being 3(2.00–4.75) years. Children with spastic quadriplegia (44.44%) and Gross Motor Function Classification System level III (41.81%) were most common. Etiologically, perinatal factors (64.54%) like perinatal asphyxia (35.45%) and prematurity (20.90%) and postnatal infections (25.45%) were common. The common comorbidities were intellectual disability (71.81%) and epilepsy (66.36%). The main treatment modalities were: antiepileptics (59.09%) and centre-based physiotherapy sessions (35.45%). School education was provided in 23.07% with special education in 11.53%.

Conclusions

This study describes the profile of CP at our centre in eastern Nepal. Predominance of perinatal complications and postnatal infections points towards the urgent need to further improve the perinatal and neonatal health care delivery system and practices.
Information needs of children with leukemia and their parents’ perspectives of their information needs: a qualitative study
Authors: Yamaji Noyuri , Nagamatsu Yasuko , Kobayashi Kyoko , Hasegawa Daisuke , Yuza Yuki , Ota Erika
Published: July 2022

Background

Despite the potential benefits of effective communication, telling a child that they have a life-threatening condition is one of the most daunting challenges. This study aimed to explore the information needs of children with leukemia from the perspectives of children and their parents at the time of diagnosis.

Methods

We conducted an exploratory qualitative study using semi-structured individual interviews with children diagnosed with leukemia between seven and 13 years old (n = 7) and their parents (n = 9). Children and parents’ interview data were analyzed using thematic analysis.

Results

We identified three themes for the information needs of children with leukemia, 1) beginning to cope, 2) avoiding disclosure – protecting child, and 3) informational support. The children and their parents needed to receive understandable information at the best time to cope with cancer. However, the children and parents expressed different views about children’s information needs. The children needed clear information about the disease, treatment, hospitalization, and the benefits of hospitalization from the time of diagnosis. In contrast, the parents felt they should not tell their children about the disease if they were in shock by their child’s cancer diagnosis. Moreover, the parents believed that information that would be incomprehensible to the child and distress should be avoided to protect their children.

Conclusions

While the information needs of children with leukemia are varied, children and their parents need the information to cope with cancer. However, if the parents believe that the information would be distressful, they might manage communication with their children. Healthcare professionals should explore the motivations behind parents’ attitudes against communication with children and confront conflict. Healthcare professionals also should communicate with the children and their parents to understand their information needs and respect children’s views.
Magnitude and associated factors of suicidal behavior among postpartum mothers attending public health centers of Addis Ababa, Ethiopia
Authors: Tilahun Selamawit , Giru Berhanu Wordofa , Snshaw Worknesh , Moges Natnael
Published: July 2022

Background

In low-income nations, suicidal conduct increases within the first year following delivery, ranging from 4 to 17.6%, with a three-fold cause of maternal death. Suicidal behavior was also reported to be 14% among postpartum women in Ethiopia.

Objective

To assess the magnitude and associated factors of suicidal behavior among postpartum mothers attending public health centers in Addis Ababa, Ethiopia, 2021.

Methods

A cross-sectional study was conducted in ten public health facilities of Addis Ababa, Ethiopia with a total sample size of 615 women. The data were entered into Epi data 4.6 and exported to SPSS version 25 for statistical analysis. A logistic regression model with adjusted odds ratio (AOR), 95% confidence interval (CI) and p-value of ≤0.05 was used to identify predictors of the outcome variable.

Results

The magnitude of suicidal behavior among postnatal mothers attending public health centers in Addis Ababa was 41.46% with 95%CI (35.2-44.5%). Being mother’s literate (adjusted odds ratio (AOR) = 0.64, 95% CI: 0.42-0.97), verbal abuses (AOR = 2.18, 95% CI: 1.38-3.44), history of rape (AOR = 3.03, 95% CI 1.14 -8.05), history of depression (AOR = 4.12, 95% CI 1.21-14.03), women’s having sexually unfaithful husband (AOR = 1.42, 95% CI 1.14-6.23) and khat chewing (AOR = 8.48, 95% CI 2.52-28.50) were significantly associated with suicidal behavior.

Conclusion

The magnitude of suicidal behavior among postnatal mothers attending public health centers in Addis Ababa was 41.46% and it was found to be associated with being literate, rape, verbal abuse, having a history of depression, having a sexually unfaithful husband and chewing khat. As a result, women should be screened for suicidal behavior during antenatal and postnatal services for early detection and management.
A longitudinal evaluation of free will related cognitions in obsessive–compulsive disorder
Authors: Moreira-de-Oliveira Maria E. , de Menezes Gabriela B. , Laurito Luana D. , Loureiro Carla P. , dos Santos-Ribeiro Samara , Fontenelle Leonardo F.
Published: July 2022

Background

Individuals with obsessive–compulsive disorder (OCD) often feel compelled to perform (compulsive) behaviors, thus raising questions regarding their free will beliefs and experiences. In the present study, we investigated if free will related cognitions (free will beliefs or experiences) differed between OCD patients and healthy subjects and whether these cognitions predicted symptom changes after a one-year follow up.

Methods

Sixty OCD outpatients were assessed for their beliefs in and experiences of free will at baseline and after one year of treatment. A subsample of 18 OCD patients had their beliefs compared to 18 age and gender matched healthy controls. A regression analysis was performed to investigate whether free will cognitions at baseline were able to predict long-term OCD severity scores.

Results

Patients with OCD and healthy controls do not seem to differ in terms of their beliefs in free will (U = 156.0; p = 0.864). Nonetheless, we found significant negative correlation between (i) duration of illness and strength of belief in determinism (ρ = -0.317; p = 0.016), (ii) age and perception of having alternative possibilities (ρ = -0.275; p = 0.038), and (iii) symptoms’ severity and perception of having alternative possibilities (ρ = -0.415; p = 0.001). On the other hand, the experience of being an owner of ones’ actions was positive correlated with the severity of symptoms (ρ = 0.538; p < 0.001) and were able to predict the severity of OCD symptoms at the follow up assessment.

Conclusions

Older individuals or those with a greater severity of symptoms seem to have a perception of decreased free will. In addition, patients with a longer duration of illness tend to have a lower strength of belief in determinism. Finally, the experience of being the owner of the compulsions, along with the baseline severity of symptoms, can be a predictor of a worse outcome in the OCD sample.
Catch me if you can! How French adolescents seize social occasions and opportunities to be active
Authors: Derigny Thibaut , Schnitzler Christophe , Remmers Teun , Van Kann Dave , Gandrieau Joseph , Seye Ndongo , Baquet Georges , Potdevin François
Published: July 2022

Background

Following an ecological framework, the aim of this study was to highlight the way adolescents invested their time in opportunities to engage in moderate to vigorous physical activity (MVPA) according to whether they were profiled as more or less active. This study’s innovation lies in the analysis of MVPA according to social occasions which are understood as opportunities to be active throughout the day (e.g. home, school, transport).

Methods

PA data measured by accelerometry (ActiGraph GT3X) for seven consecutive days were compiled, with adolescents’ social occasions during the week recorded in a daily digital diary (n = 135). The opportunity ratio of MVPA at each social time is the ratio between time spent in MVPA and the duration of a corresponding social occasion. Following the literature, participants were categorised into three profiles according to their reported amount of MVPA: HEPA active, minimally active and inactive. Non-parametric Wilcoxon signed rank and Kruskal Wallis tests were performed to determine the relative intensity of PA performed at different social occasions, and to investigate whether intensities differed between adolescents with various activity profiles.

Results

Results showed that engagement in MVPA at different social occasions differed according to participant profiles. Mismatch was noticed between the opportunity ratio and the duration of the most and least favorable social occasions for MVPA. For all three profiles, the social occasion “physical education lesson” revealed an opportunity ratio of MVPA (23.6% vs 17.0% vs 13.8%) significantly higher than the overall opportunity ratio of the week (6.9% vs 2.9% vs 1.2%), but of lower duration. Conversely, “home” (5.3% vs 0.0% vs 0.0%) and “school” (outside of PE time) (2.4% vs 0.0% vs 0.0%) represented the two least opportune social occasions for PA in an adolescent’s week.

Conclusions

Rethinking engagement with MVPA in the context of temporal opportunities would allow potential ways to intervene within an educational supervised setting to help young people adopt a physically active lifestyle at the end of the key period of adolescence. These results reinforced the importance of context in interventions for PA promotion, opening for “time education” in people.
Generation of genome-edited dogs by somatic cell nuclear transfer
Authors: Kim Dong-Ern , Lee Ji-Hye , Ji Kuk-Bin , Park Kang-Sun , Kil Tae-Young , Koo Okjae , Kim Min-Kyu
Published: July 2022

Background

Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease.

Results

We constructed a CRISPR-Cas9 vector targeting canine DJ-1. Genome-edited canine fibroblasts were established using vector transfection and antibiotic selection. We performed canine SCNT using genome-edited fibroblasts and successfully generated two genome-edited dogs. Both genome-edited dogs had insertion-deletion mutations at the target locus, and DJ-1 expression was either downregulated or completely repressed.

Conclusion

SCNT successfully produced genome-edited dogs by using the CRISPR-Cas9 system for the first time.
Justification for requiring disclosure of diagnoses and prognoses to dying patients in saudi medical settings: a Maqasid Al-Shariah-based Islamic bioethics approach
Authors: Alfahmi Manal Z.
Published: July 2022

Background

In Saudi clinical settings, benevolent family care that reflects strongly held sociocultural values is commonly used to justify overriding respect for patient autonomy. Because the welfare of individuals is commonly regarded as inseparable from the welfare of their family as a whole, these values are widely believed to obligate the family to protect the welfare of its members by, for example, giving the family authority over what healthcare practitioners disclose to patients about their diagnoses and prognoses and preventing them from making informed decisions about their healthcare.

Discussion

Family dominance over the healthcare decisions of competent patients is ethically problematic when the family prevent healthcare practitioners from disclosing diagnoses and prognoses to patients who have the capacity to consent and make decisions in their own best interests. Thus, the author holds that sociocultural values ought to be respected only when they do not prevent competent patients from knowing their diagnoses and prognoses or prevent them from making their own decisions.

Conclusion

Healthcare practitioners should not allow patients’ families to control what can or cannot be disclosed to competent patients. This is particularly important when patients are approaching death so that they may address their material and spiritual wishes—among other needs—as they prepare for death. Justification for this position is drawn from the Maqasid Al-Shariah-based Islamic bioethics approach, from which it is possible to argue that the harm of withholding diagnoses and prognoses from patients who are imminently dying outweighs the potential benefits.
Modelling in economic evaluation of mental health prevention: current status and quality of studies
Authors: Ha Nguyen Thu , Huong Nguyen Thanh , Anh Vu Nguyen , Anh Nguyen Quynh
Published: July 2022

Background

The present study aimed to identify and critically appraise the quality of model-based economic evaluation studies in mental health prevention.

Methods

A systematic search was performed on MEDLINE, EMBASE, EconLit, PsycINFO, and Web of Science. Two reviewers independently screened for eligible records using predefined criteria and extracted data using a pre-piloted data extraction form. The 61-item Philips Checklist was used to critically appraise the studies.Systematic review registration number:CRD42020184519.

Results

Forty-nine studies were eligible to be included. Thirty studies (61.2%) were published in 2015–2021. Forty-seven studies were conducted for higher-income countries. There were mainly cost-utility analyses (n = 31) with the dominant primary outcome of quality-adjusted life year. The most common model was Markov (n = 26). Most of the studies were conducted from a societal or health care perspective (n = 37). Only ten models used a 50-year time horizon (n = 2) or lifetime horizon (n = 8). A wide range of mental health prevention strategies was evaluated with the dominance of selective/indicate strategy and focusing on common mental health problems (e.g., depression, suicide). The percentage of the Philip checkilst’s criteria fulfilled by included studies was 69.3% on average and ranged from 43.3 to 90%. Among three domains of the Philip checklist, criteria on the model structure were fulfilled the most (72.1% on average, ranging from 50.0% to 91.7%), followed by the data domain (69.5% on average, ranging from 28.9% to 94.0%) and the consistency domain (54.6% on average, ranging from 20.0% to 100%). The practice of identification of ‘relevant’ evidence to inform model structure and inputs was inadequately performed. The model validation practice was rarely reported.

Conclusions

There is an increasing number of model-based economic evaluations of mental health prevention available to decision-makers, but evidence has been limited to the higher-income countries and the short-term horizon. Despite a high level of heterogeneity in study scope and model structure among included studies, almost all mental health prevention interventions were either cost-saving or cost-effective. Future models should make efforts to conduct in the low-resource context setting, expand the time horizon, improve the evidence identification to inform model structure and inputs, and promote the practice of model validation.
Minimally invasive mini-hemilaminectomy-corpectomy in cadaveric dogs: evaluation of the accuracy and safety of a three-dimensionally printed patient-specific surgical guide
Authors: Kang Jinsu , Lee Seungeon , Kim Namsoo , Heo Suyoung
Published: July 2022

Background

As the frequency of spine surgery increases in the veterinary field, many studies have been conducted on minimally invasive spine surgery (MISS). Although many studies have been conducted on the thoracolumbar spine about MISS in animals, several problems and limitations have emerged regarding this method. Therefore, we developed a three-dimensional (3D) printed patient-specific surgical guide (3DPSSG) using 3D printing technology to overcome these problems. We aimed to evaluate the accuracy and safety of the 3DPSSG in minimally invasive mini-hemilaminectomy-corpectomy (MI-MHC).

MI-MHC using 3DPSSG and an endoscopic system was performed at L1–L2 in 15 cadaveric dogs. The procedure of fixing the surgical guide to the vertebral body through screws and the surgical procedure using the guide were performed by two surgeons with different experiences. Postoperative computed tomography was used to measure planned and postoperative screw trajectories (angle, protruding from the far cortex) and to create 3D rendering images of vertebrae to evaluate the direction of bone window formation, corpectomy slot length, depth, and height ratio.

Results

The two groups which performed by two surgeons with different experiences did not differ in terms of screw angle deviation and length of the screw protruded from the far cortex. The corpectomy slot-length ratio was not different between the two groups; however, the slot-depth and height ratios were different.

Conclusions

No differences were detected in screw trajectory and corpectomy slot-length ratio between the two groups. The 3DPSSG for MI-MHC is classified as accurate and safe; therefore, it can be an alternative to the conventional technique in dogs.
Reference values of impulse oscillometry (IOS) for healthy Chinese children aged 4–17 years
Authors: Wu Jinhong , Zhang Hao , Shi Yongsheng , Wang Jinrong , Han Yuling , Zhang Qiaoling , Wang Ning , Liu Sha , Zhang Yuehua , Zi Huifen , Wang Fei , Liu Aihong , Song Yuxin , Jia ChunMei , Feng Yong , Liu Quanhua , Wan liya , Ji Minghong , Long Zhen , Huang Jianfeng , Liu Li , Sun Yun , Tang Suping , Dong Xiaoyan , Zhou Xiaojian , Jiang Wenhui , Shen Li , Jiang Haohua
Published: July 2022

Objective

To establish the predicted value of pulmonary function determined by impulse oscillometry (IOS) in children (4–17 years old) in China.

Methods

A total of 6270 healthy children aged 4–17 years in China were included. The Master Screen IOS pulmonary function device (Jaeger Co, Germany) was used to detect the respiratory impedance (Zrs), resonant frequency (Fres), respiratory system resistance (Rrs) and respiratory system reactance (Xrs) at various oscillation frequencies, and the indices above were analysed. Stepwise multivariate regression was used to establish the regression equation of related parameters of IOS in different sexes, ages, height, and weight.

Results

The differences in the main IOS parameters between different age stages were statistically significant regardless of sex (P < 0.05). The stepwise multivariate regression analysis showed that IOS parameters were related to height, age, and weight, and most IOS parameters were most closely related to height (the absolute value of the regression coefficient was the largest). With increasing age and height, the values of Z5, R5, R20, R5–R20, and Fres decreased, while the value of X5 increased. Through height, age, and weight, we obtained the normal predicted values equation of children’s IOS parameters. Compared with the other reference equations, our reference equation is more suitable for Chinese children.

Conclusions

The study revealed the reference values of IOS parameters in healthy Chinese children. In the evaluation of results for lung function measurements, this predicted value equation is more consistent with the characteristics of Chinese children than other reference equations.

Clinical Trial: ChiCTR: 1800019029.
Sarcopenia is associated with cardiovascular risk in men with COPD, independent of adiposity
Authors: Leem Ah Young , Kim Young Sam , Chung Kung Soo , Park Moo Suk , Kang Young Ae , Park Young-Mok , Jung Ji Ye
Published: July 2022

Background

Sarcopenia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD), but its relationship with chronic obstructive pulmonary disease (COPD) has not been fully determined. This study is aimed to investigate the association between sarcopenia and risk for ASCVD in patients with COPD, independent of central obesity and fat mass.

Methods

Data regarding 704 men with COPD (mean age: 63.4 years) were extracted from the 2008 to 2011 Korean National Health and Nutrition Examination Surveys. Sarcopenia index and fat mass were assessed using dual-energy X-ray absorptiometry. Sarcopenia was defined according to the presence of sarcopenia index values < 1 standard deviation from the cutoff (0.774) among the study participants. ASCVD risk was evaluated using American College of Cardiology/American Heart Association guidelines. High probability of ASCVD was defined as ASCVD risk > 20%.

Results

The quartile-stratified sarcopenia index was negatively associated with ASCVD risk (P < 0.001). ASCVD risk and prevalence of high ASCVD risk were significantly greater in sarcopenic participants than in non-sarcopenic participants, regardless of central obesity and fat mass (all P < 0.001). Multivariate regression analyses demonstrated an independent association between sarcopenia and ASCVD risk (estimated ± standard error = 3.63 ± 0.77%, P < 0.001) and high ASCVD risk (odds ratio [OR] = 2.32, 95% confidence interval [CI] 1.05–5.15, P = 0.039). Furthermore, sarcopenia was an independent factor for high ASCVD risk in participants with moderate to very severe airflow limitation (OR = 2.97, 95% CI 1.06–8.36, P < 0.001).

Conclusions

Sarcopenia was significantly associated with an increased risk for ASCVD in men with COPD, independent of central obesity and fat mass. High ASCVD risk was significantly associated with sarcopenia, particularly in participants with moderate to very severe airflow limitation.