bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
Authors: Mehra Reema Kapoor , Gupta Prakriti , Singh Navpreet
Published: August 2022

Introduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 among the Indian population. Methods: The study consisted of 730 patients admitted to Jaya Arogya Hospital, Gwalior, with COVID-19 from August 2020 to December 2020. The patients were divided into mild disease group (MDG) (n=533) and severe disease group (SDG) (n=197) depending on certain criteria, and their biochemical and inflammatory markers were collected. Data were analyzed using SPSS version 25. Results: Statistically significant rise in blood urea (P=0.011), serum creatinine (P=0.008), serum bilirubin (P=0.012), interleukin 6 (IL-6) (P<0.001), and troponin I (P<0.001) was observed in SDG as compared to MDG. Serum electrolytes (sodium and potassium) and serum protein (total protein and albumin) showed a significant fall in SDG as compared to MDG (P<0.001 for electrolytes and P=0.023 for proteins). The area under the receiver operating characteristic curve (AUROC) showed a high diagnostic value of IL-6. Conclusion: Patients with severe COVID-19 showed a high prevalence of hyperbilirubinemia, hypoproteinemia, electrolyte imbalance, and raised inflammatory markers (IL-6, troponin I, and procalcitonin). Results showed their effectiveness in assessing disease severity and predicting outcomes in patients with COVID-19.
The role of history of blood pressure and diabetes in the prevalence of stroke in Azar cohort
Authors: Hejazi Salva , Alizadeh Mahasti , Dastgiri Saeed
Published: August 2022

Introduction: The prevalence of diabetes and hypertension has been growing steadily in the last decade. These are important risk factors for stroke and the contribution of each risk factor may change due to geographical location. We conducted the present study with the aim of determining the relationship between blood pressure and diabetes history and stroke in the population covered by the Azar Cohort. Methods: In this case control study which was a subset of Azerbaijan province study (Azar Cohort), 357 patients were divided into patients with and without a history of stroke. The two variables of hypertension and diabetes history, in these two groups were compared. Data were collected and compared with inferential statistical tests. Results: The results showed that blood pressure could increase the risk of stroke by 3.68 times (95% CI: 2.32-5.86). The history of diabetes mellitus in people with and without stroke was not statistically significant (OR=1.54; 95% CI: 0.87-2.72). Conclusion: The results of this study showed that high blood pressure is a predictor of stroke but diabetes cannot be effective in stroke in the cohort population of Azerbaijan.
Factors associated with disease severity and length of stay in hospitalized COVID-19 patients in Tabriz, Iran: A retrospective cohort study
Authors: Asghari Elnaz , Hosseinzadeh Mina , Mahdavi Nader , Mahmoodi Vahide
Published: August 2022

Introduction: The novel coronavirus disease (COVID-19) has spread globally. Early and dynamic detection of prognostic factors is essential to improve the ability to treat COVID-19. The present study aimed to determine clinical characteristics and risk factors associated with the length of hospital stay and disease severity in hospitalized COVID-19 patients in Tabriz, Iran. Methods: This retrospective cohort study included 260 early diagnosed cases with COVID-19 hospitalized at two COVID-19 specialized hospitals in Tabriz, Iran, from April 20 to June 20, 2020. Patients’ medical records were used to collect the data. Severe COVID-19 outcomes included need for intubation, admission to the intensive care unit, or death. The data were analyzed using descriptive and analytical statistics, including chi-squared test, Mann-Whitney U test, and logistic regression analysis in SPSS 16. Results: The need for O2 therapy (adjusted odds ratio [AOR]=4.23; 95% CI: 1.15‒15.51; P=0.03), the increased creatinine levels (AOR=2.71; 95% CI: 1.25‒5.88; P=0.01), and the white blood cell counts (AOR=2.44; 95% CI: 1.12‒5.33; P=0.02) were the main risk factors associated with prolonged hospital stay. Also, having kidney diseases (AOR=7.33; 95% CI=1.94‒27.70; P=0.01), elevated the white blood cell counts (AOR=4.52; 95% CI=1.67‒12.26; P=0.003), and lung diseases (AOR=3.97; 95% CI: 1.18‒13.29; P=0.03) were significant among the predictors of the disease severity. Conclusion: According to the results, hypoxia and underlying diseases might lead to unwanted outcomes. The risk factors identified here confirm previous information and could be helpful to guide early clinical decision-making to reduce the mortality rates and improve the clinical outcomes of COVID-19.
The effectiveness of habit reversal training with cognitive behavior therapy on quality of life and symptoms of trichotillomania patients
Authors: Hamid Najmeh , Bordbar Maryam , Marashy Seyed Ali
Published: August 2022

Background. The aim of this research was to investigate the effect of Habit Reversal Training on Anxiety, Quality of life and Symptoms of Trichotillomania patients. This quasi experimental study was designed with pretest-posttest and control group. Methods. The statistical population consisted of all female patients with trichotillomania disorder referring to the Mashhad medical clinics. A sample of 24 subjects had criteria for entering the research, were available selected and matched from age, educational status, not suffering from acute physical and mental disorder and other criteria considered in this research. Then randomly divided into two experimental (12) and control (12) groups. The experimental administered habit reversal training with cognitive behavior therapy for 8 sessions of 1 hour, while the control group did not receive such training. The data was analyzed by ANCOVA & MANCOVA test using SPSS-21. Results. The results showed that habit reversal training had a significant positive effect on quality of life, anxiety and symptoms of trichotillomania in experimental group in comparison with pretest and control group (P<0.001), so that the experimental group showed less symptoms of trichotillomania after the intervention and showed higher quality of life. Conclusion. According to the results of this study, it can be concluded that habit reversal training has a positive effect on quality of life and symptoms of trichotillomania of patients with trichotillomania. Therefore, habit reversal training may be considered as one of the main treatments for this disorder. Practical Implications. Patients with Trichotillomania (TTM) have a high level of stress, which is often alleviated by the habit of hair loss. Cognitive-behavioral therapy combined with habit reversal has a positive effect on the quality of life of patients with Trichotillomania (TTM). Cognitive-behavioral therapy combined with habit reversal has a positive effect on symptoms of patients with Trichotillomania (TTM). The use of cognitive-behavioral with habit reversal interventions to strengthen the will of Trichotillomania (TTM) patients with drug therapy is recommended.
Development and implementation of a community-based suicide prevention program in primary care
Authors: Farahbakhsh Mostafa , Fakhari Ali , Azizi Hosein , Davtalab Esmaeili Elham , Sadegh Tabrizi Jafar , Mirzapour Mohammad , Dorosti Abbasali , Vahab Aslrahimi
Published: August 2022

Background. Suicide is recognized as a public health issue in Malekan County through a health community assessment. A community-based suicide prevention program was conducted during 2014-2017. Methods. This health system research was conducted in seven steps, including conducting systematic reviews, gathering expert opinions, improving the coverage of suicide attempt records, conducting research to identify regional risk factors, conducting follow ups and managing the individuals attempting suicide, training health gatekeepers, and launching public awareness campaigns. Our goal was to lower the rates of suicide, and suicide attempt by 15% and 20%, respectively. Multiple logistic regression was calculated to estimate the adjusted odds ratios and the 95% confidence intervals. Result. 821 suicide attempts and 32 suicides had been recorded in the county. 70% of the suicides had been committed by men while the majority of attempters were females (64%). Most of the suicides (18cases-56.25%) had occurred in the spring while the majority of suicide attempts (288cases-35.8%) had been recorded in the summer. The common methods (62%) suiciders used were hanging and poisoning, which increased death risk significantly (OR: 8.5, 95% CI: 2.9–76.99). The incidence rates of suicide and suicide attempts reduced from 11.22, and 203 per 100,000 in 2013 to 2.63, and 157 in 2017, respectively. Suicide re-attempts also diminished from 12% in 2013 to 6.7% in 2017. Conclusion. Suicide, SA, and re-attempt were lowered by 75%, 22%, and 42%, respectively. Practical Implications. The practical framework that emerged out of the present study can be used for generating future suicide prevention strategies. Furthermore, our study highlights the need to consider a wide range of contextual factors when developing suicide prevention programs.
Effect of Delphinium denudatum Wall. (Jadwar) on Knee Osteoarthritis: A Randomized Double-Blinded Placebo-Controlled Clinical Trial
Authors: Baghervand Navid Roghayeh , Karimi Mehrdad , Ghojazadeh Morteza , Bagherzadeh-Karimi Alireza , Mohammadinasab Reza , Dolati Sanam , Basnas Mehri , Cheraghi Roya , Fazljou Seyed Mohammad Bagher
Published: August 2022

Background: Osteoarthritis (OA) is the most common disease of joints. The management of OA is challenging due to the efficacy and safety of treatments. In recent decades, traditional herbal medicines have been introduced for treatment of disease. Delphinium denudatum Wall. (Jadwar) is a medicinal herb with a long-lasting usage in traditional Persian medicine for joint diseases. The present study aimed to investigate the effect of Jadwar on pain and symptoms of knee OA. Methods: In this randomized double-blind placebo-controlled trial, 104 patients with knee OA were randomly assigned into two groups of intervention and control. While the intervention group received one Jadwar capsule (500 mg) twice a day for four weeks, the control group received placebo capsules. The primary outcomes, including pain, stiffness, and physical activity were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire and the Visual Analogue Scale (VAS) at baseline two and four weeks after the intervention. Results: Ninety-four participants completed the study. Considering the time of interaction, after four weeks, data analysis revealed a significant decrease in the VAS score (37.23±12.58 vs. 57.87±13.21), total WOMAC score (24.83±9.70 vs. 49.17±12.89), WOMAC pain score (7.19±2.90 vs. 12.40±4.46), stiffness (2.06± 0.845 vs. 4.11±1.14), and physical function (15.57±7.25 vs. 32.66±9.78) in the intervention group compared to the control group (P<0.0001 for all outcomes). Additionally, no serious adverse effects were reported. Conclusion: Jadwar can be suggested as a safe medicinal plant for knee OA because it can relieve the pain and symptoms of OA.
Phytochemical analysis and antioxidant activity of eight cultivars of tea (Camellia sinensis) and rapid discrimination with FTIR spectroscopy and pattern recognition techniques
Authors: Yousefbeyk Fatemeh , Ebrahimi-Najafabadi Heshmatollah , Dabirian Sara , Salimi Salar , Baniardalani Farshid , Ghasemi Saeed
Published: August 2022

Background: Tea (Camellia sinensis L.O. Kuntze) is one of the most commonly consumed beverages globally, with several beneficial health effects. The composition of leaves is affected by different factors such as climate and tea cultivar. Methods: In this study, the total phenolic, flavonoid, and tannin contents, and antioxidant activities of eight cultivars of tea growing in Iran were determined. The epigallocatechin gallate (EGCG) contents were measured by high-performance liquid chromatography (HPLC) analysis. The Fourier-transform infrared (FT-IR) spectra were used to construct a supervised pattern recognition model using a genetic algorithm-support vector machine (GA-SVM) for the classification of cultivars. Results: The results indicated a wide variation of total phenolic content (178.04 to 316.09 mg gallic acid equivalents (GAE)/g extract). Also, the flavonoid contents ranged from 25.54 to 41.1 mg quercetin equivalents )QE(/g extract. All the samples had close tannin amounts (ranging from 40.32 to 45.90 mg as tannic acid equivalent (TAE)/g extract). There was a significant linear relationship among total phenolic and flavonoid contents and antioxidant properties. The cultivars DN, PK2, and C.Y.9 had the highest content of phenolic and flavonoid content as well as the best antioxidant activity. The EGCG contents were from 2.66 to 4.12%. The highest amount of EGCG was found in cultivars 282, PK2, and C.Y.9. The discriminative region of FT-IR spectra (1350-1650 cm-1) were selected using a GA-SVM. This model showed 100% sensitivity and specificity for training and test sets. Conclusion: The leaves phytochemical compositions and antioxidant effect are deeply dependent on the type of tea cultivars. The cultivars PK2 and C.Y.9 can be considered richer sources of polyphenols, especially EGCG. The eight different cultivars can be classified based on chemical components using the recorded FT-IR spectra.
Characterization and Biological Activities of Silver Nanoparticles Synthesized using Grewia tiliifolia Vahl Leaf Extract
Authors: Desai K Sneha , Taranath Tarikere C
Published: August 2022

Background: An eco-friendly approach for the synthesis of noble metal nanoparticles employing various plant extracts has become of great interest in the field of nanotechnology. In the present study, the efficacy of Grewia tiliifolia leaf extract in reducing 1mM silver nitrate to silver nanoparticles(AgNPs) has been reported for the first time and also we investigated the anticancer, antituberculosis and antioxidant activity. Methods: Characterization of biosynthesized AgNPs using G. tiliifolia leaf extract was evaluated by Uv-Vis, FTIR, XRD, DLS and TEM with SAED. Efficacy of biosynthesized AgNPs using G. tiliifolia leaf extract was tested for cytotoxicity against A549 Lung cancer cell lines by MTT Assay and also against the infectious agent Mycobacterium tuberculosis using MABA Assay. Further antioxidant activity was evaluated by DPPH radical scavaging assay. Results: The biosynthesis of AgNPs was evident by color change of reaction mixture from dark yellow to reddish-brown. Biofabricated AgNPs was further confirmed by characteristic surface plasmon absorption peak at 409nm by UV-vis analysis. FTIR data reveals the presence of phytochemicals involved in bioreduction and biocapping of AgNPs, XRD analysis depicted crystallographic nature of AgNPs. Further, size, charge, and polydispersity nature were studied using DLS (40.2nm with polydispersity index 0.361) and Zeta potential (-35.8mV). The morphology of AgNPs was determined by TEM analysis with size ranging from 11-34nm. The plant derived AgNPs exhibited a cytotoxic effect on the Lung cancer cell line with IC50 value of 23.45µg/ml and also found to be effective against M. tuberculosis with a MIC of 6.25µg/ml in comparison to the leaf extract (MIC 50µg/ml). Antioxidant activity observed by AgNPs was moderate with IC50 value 49.60 µg/ml. Conclusion: The findings indicate that the AgNPs synthesized from leaf extract of G. tiliifolia are eco-friendly, cost-effective, non-toxic and can be the effective natural anticancer, antituberculosis agents and antioxidant agent.
Fasudil Attenuated 6-OHDA Cytotoxicity in PC12 Cells through Inhibition of JAK/STAT and Apoptosis Pathways
Authors: Barangi Samira , Hosseini Seyyed Masoud , Karimi Gholamreza , Mehri Soghra
Published: August 2022

Background: 6-Hydroxydopamine (6-OHDA) is widely used to induce neurotoxicity and investigate the mechanisms of Parkinson disease. 6-OHDA causes cell injury through various mechanisms including oxidative stress, inflammation and apoptosis. The selective Rho-kinase inhibitor, fasudil displays neuroprotective effects in several neurodegenerative disorders. The aim of this study was to assess the protective effect of fasudil in PC12 cytotoxicity induced by 6-OHDA. Methods: PC12 cells were exposed to 5, 10, 25, and 50 µM of fasudil concentrations. After 24 h, the IC50 value of 6-OHDA (150 µM) was added. Twenty-four hours later, the viability of cells was evaluated via MTT assay and the formation of reactive oxygen species (ROS) was measured by the fluorimetric method. At the 50 µM concentration of fasudil, with or without 6-OHDA, the changes of protein levels including STAT3, P-STAT3, JAK2, P-JAK2, and caspase-3 were determined via western blotting. Results: Our results showed that 6-OHDA increased the intracellular level of ROS, reduced cell viability, upregulated p-STAT3/STAT3 and p-JAK2/JAK2 ratios and significantly raised cleaved caspase-3 in comparison to control group. Furthermore, pretreatment of cells with fasudil (50 µM) for 24 h could reverse all changes induced by 6-OHDA. Conclusion: 6-OHDA caused cytotoxicity in PC12 cells through inducing oxidative stress and activating JAK/STAT and apoptosis pathways, while pretreatment with fasudil exhibited protective effect on 6-OHDA-induced neurotoxicity via the inhibition of oxidative stress and prevention of these pathways.
Sensing of Letrozole Drug by Pure and Doped Boron Nitride Nanoclusters: Density Functional Theory Calculation
Authors: Behmanesh Afsoon , Salimi Farshid , Ebrahimzadeh-Rajaei Gholamreza
Published: August 2022

Background: Letrozole is a non-steroidal drug utilized as a treatment of hormone-sensitive breast cancer. It has been shown that letrozole has harmful side effects. Therefore, it seems necessary to design a letrozole drug sensor. In this work, we scrutinized the sensing properties of the B30N30, AlB29N30, and GaB29N30 nanoclusters toward the letrozole drug in various adsorption sites. Methods: Investigations were done using the density functional theory (DFT) calculation with the B3PW91/6-311G(d, p) level of theory. The time-dependent density functional theory (TD-DFT) calculations were used to investigate Ultraviolet-visible (UV-vis) spectrums with the same level of theory. Results: The adsorption energy of B30N30, AlB29N30, and GaB29N30 in the most stable complexes were calculated at -16.81, -34.62, and -27.41 kcal mol-1, respectively. The results obtained from the study of electronic properties showed a high sensitivity for the detection of letrozole in B30N30 compared to AlB29N30 and GaB29N30. The calculated recovery time for the B30N30 is 0.13 × 10-5 s, which indicates a very short recovery time. The UV-vis spectrums showed that the letrozole/B30N30 exhibits shift toward the higher wavelengths (red shift). Conclusion: Therefore, these results showed that the B30N30 is a good candidate for identifying letrozole. Further, B30N30 would be more effective than AlB29N30 and GaB29N30 due to the simple synthesis.
Strategies of Manushyaputhira's Poems
Authors: K Thennarasu , S Balu
Published: August 2022

Even though there are various fields in modern literature, Pudukavithai also holds a special place for itself. Such poems have been creating Pudukavithai starting from Bharathiyar to till the present day poets. A strategy is a method in which the creator of works uses a technique of his own to make his work tasteful and innovative according to his imagination, according to his language skills, different from other works. A technique is a method of creating art, the seal of the creators in creation. It reveals the personality traits of the creators. It is the techniques used by the creator rather than the ideas expressed in the works that make the artwork perfect. Their creativity and strategies play an important role in achieving success. Poets have also used different techniques to convey the ideas of the pudhukavithai to the readers as per the technique that can be used. Manushyaputhiran is one of them. His poems are about the problems of contemporary people. He has used simple techniques to make his poems understandable to the readers. This article depicts the sufferings happening in the society through images, similes, metaphors and myths through poems.
XENON ANESTHESIA IN A CHILD WITH AUTISM DURING DENTAL TREATMENT (CLINICAL CASE)
Authors: Лазарев В.В. , Халиуллин Д.М. , Габдрафиков Р.Р. , Грачева Е.С. , Кузнецова Е.Е.
Published: August 2022

Аутизм сложное расстройство, требующее междисциплинарного подхода. Цель исследования: Оценить неврологический статус у ребенка с аутизмом в периоперационном периоде при стоматологическом лечении с использованием комбинированной ингаляционной анестезии на основе ксенона. Материалы и методы: Проведено клиническое наблюдение ребенка с аутизмом, которому проведена санация полости рта с применением ксеноновой анестезии. Результаты: Отмечены положительные изменения в психическом статусе у ребенка с аутизмом после анестезии ксеноном. Выводы: Авторы считают перспективным изучение влияния ксенона на психоэмоцианальную сферу у детей с патологией ЦНС

Autism is a complex disorder that requires an interdisciplinary approach. Objective: To assess the neurological status of a child with autism in the perioperative period in dental treatment using combined inhalation anesthesia based on xenon. Materials and methods: A clinical observation of a child with autism, who conducted the oral cavity sanation with the use of xenon anesthesia. Results: There were positive changes in the mental status of a child with autism after xenon anesthesia. Conclusions: The authors consider it promising to study the influence of xenon on the psychoemotional sphere in children with CNS pathology
PHYTOTHERAPY IN ONCOLOGY
Authors: Жуковская Е.В. , Петрушкина Н.П.
Published: August 2022

В обзоре авторы обсуждают возможность применения фитопрепаратов для лечения злокачественных новообразований. В историческом аспекте растительное сырье всегда было источником разработки противоопухолевых препаратов. В народной медицине чага, болиголов и другие использовались веками. Современная фармакология, выделяя из растений действующее начало, синтезирует аналоги, доводя их до уровня лекарственных препаратов. Важная роль принадлежит растениям благодаря выработке фитохимических соединений, обладающих антипролиферативной, иммуномодулирующей активности. Примерами терапевтического потенциала продуктов растительного происхождения являются ингибирующие микротрубочки алкалоиды барвинка, ингибитор ДНКтопоизомеразы I, камптотецин, терпенпаклитаксел или лигнаны этопозид и тенипозид, полученные из подофиллотоксина. Использование омических технологий, цитогенетические методы, метаболомные и т. п., обеспечивают получение субстанций из растительного сырья для создания таргетных препаратов и прецизионной медицины

In the review, the authors discuss the possibility of using herbal remedies for the treatment of malignant neoplasms. In the historical aspect, plant raw materials have always been sources of the development of anticancer drugs. In folk medicine, chaga, hemlock and others have been used for centuries. Modern pharmacology, isolating the active principle from plants, synthesizes analogs leading them to the level of drugs. An important role belongs to plants due to the production of phytochemical compounds with antiproliferative, immunomodulatory activity. examples of the therapeutic potential of products of plant origin are microvule inhibitory vinca alkaloids, DNAinhibitor topoisomerase I, camptothecin, terpenepaclitaxel or lignans obtained from podophyllotoxin, etoposide and teniposide. substances from vegetable raw materials for the creation of targeted drugs and precision medicine
RENDIMIENTO, COMPONENTES DE RENDIMIENTO Y HETEROSIS DE GERMOPLASMA DE MAÍZ ADAPTADO A VALLES ALTOS
Authors: Velasco-García Ángela M. , García-Zavala J. Jesús , Sahagún-Castellanos Jaime , Lobato-Ortiz Ricardo , Sánchez-Abarca Carlos , Marín-Montes Iván M.
Published: August 2022

Las variedades de maíz (Zea mays L.) introducidas de otras latitudes son una fuente de alelos favorables de utilidad en el mejoramiento genético, pero antes de ser empleados deben adaptarse a las condiciones climáticas de los ambientes de interés. El objetivo del presente estudio fue evaluar el rendimiento y sus componentes en poblaciones representativas de razas de maíz originarias del trópico y subtrópico adaptadas por selección masal recurrente a los Valles Altos de México,  así como la heterosis de sus cruzas interraciales para identificar genotipos útiles al mejoramiento genético del maíz para esos ambientes. Se evaluaron nueve poblaciones de maíz adaptado, ocho cruzas de dos poblaciones, una cruza de tres  poblaciones, generaciones avanzadas de las cruzas y cuatro testigos comerciales. Los genotipos se evaluaron en tres ambientes bajo un diseño experimental de bloques completos al azar con tres repeticiones. Se registró el rendimiento y sus  componentes. Se realizó análisis de varianza, comparación de medias (Tukey, P ≤ 0.05), análisis de correlación y se estimó la heterosis con respecto al progenitor medio. Hubo diferencias significativas (P ≤ 0.01) entre genotipos para todos los caracteres; los materiales adaptados rindieron de 3.89 a 11.71 t ha-1 y los testigos de 8.06 a 11.56 t ha-1. El rendimiento correlacionó con el índice de prolificidad (r = 0.67), longitud (r = 0.64), diámetro de mazorca (r = 0.65) y número de granos por hilera (r = 0.64). La heterosis promedio para rendimiento y sus componentes fluctuó de -5.30 a 6.53 %, con 5.68 % para rendimiento, donde la cruza F1 P9 × P8 presentó la mayor heterosis (26.19 %). Las poblaciones adaptadas y sus cruzas presentaron rendimientos similares a los testigos comerciales; por esto, pueden aprovecharse per se o como participantes para mejoramiento genético del maíz local de Valles Altos.
A Study on College Students’ Perception Types of Fetus and Abortion Through Q Methology
Authors:   Catholic Institute of Bioethics, Lee O Bok
Published: August 2022

This study intended to investigate college students’ subjective perception types of fetus and abortion. To this end, it used 31 statements related to fetus and abortion, and forty participants classified the statements. The Q Classification identified the undergraduate students’ perception of fetus and abortion into four types.  ‘a type of pregnant woman priority over the fetus’ prioritizes the life of a pregnant woman and her right to make decisions on an abortion. ‘fetal-first type - the human fetus that needs to be protected over women’ perception type means that It is a perception that the right to life should be protected because ‘the fetus is a growing human being’.  is the ‘Circumstances Priority - allowing abortion in case of unavoidable circumstances’ type, and it is the opinion that abortion can be performed according to realistic circumstances or reasons.  is ‘an abortion prevention type - prevention of side effects caused by compulsive childbirth’ and childbirth in an unprepared state as a parent was recognized as having another risk of side effects. Based on the results of the study, the necessity of activities for sex education, Bioethics Education, and establishing a system to support child rearing of unmarried parents was suggested for the establishment of right values for sex among college students. It is expected that the results of this study can be used as basic data for finding ways to prevent abortion in the future despite the limitation on the number of data collection subjects and regional limitations caused by using the Q methodology.
Nuevos retos en la administración de justicia: el uso de las tecnologías de información y comunicación
Authors: Yépez Provincia Lizbeth Nohemi
Published: August 2022

La administración de justicia en el Perú, como toda acción humana en nuestra sociedad, ha ido sufriendo cambios a lo largo de los años. Desde la última década, aún más acelerados, producto de los diversos avances tecnológicos y la implementación de estos en la Administración de Justicia Peruana. Por lo que este ensayo busca identificar los principales retos que la Administración de Justicia viene afrontando y encontrar posibles soluciones.
Reflexiones sobre el despido en el Perú en el Bicentenario
Authors: Jaimes Reátegui Susan
Published: August 2022

El título del artículo responde a mi experiencia como jueza del Juzgado Especializado de Trabajo de Huánuco. A partir de los apuntes de los procesos resueltos sobre los diversos tipos de despido presentados en mi juzgado, se analizan los datos en cuadros estadísticos para establecer cuáles han sido los tipos de contratos que originaron los ceses de trabajadores afectados. Se obtiene que las demandas fueron resueltas con la ley, la jurisprudencia y la doctrina que en el Perú se han instaurado en el devenir de los años, y se concluye que los obreros han sido los más afectados y las municipalidades las más demandadas. Finalmente, se plantean propuestas para evitar los despidos injustificados y/o arbitrarios, y se explica el alcance del precedente vinculante del caso Huatuco.
Hubungan Pengetahuan dengan Perilaku Pencegahan Penularan Covid-19 Pada Ibu Hamil
Authors: Fitria Nurwulansari  , Solihah
Published: August 2022

Non-natural disasters caused by the Corona Virus or Covid-19 have spread and have an impact on maternal and child health problems. Covid-19 virus infection in pregnant women as a vulnerable group worsen the conditions of their pregnancy. Thus, an understanding of Covid-19 and its prevention is needed which will increase the awareness of pregnant women to take preventive measures against Covid-19. The purpose of this study was to analyze the relationship between knowledge and Covid-19 prevention behavior in pregnant women in the Independent Practice of Midwife "T" Bandung Regency. The research design was analytic observational using a cross-sectional approach which was carried out in 2020. The respondents were 55 pregnant women who were selected using a purposive sampling technique. The research instrument used a questionnaire to measure knowledge and behavior to prevent Covid-19. Data analysis were univariate analysis and bivariate analysis using chi square. The results showed that there was a significant relationship between knowledge and Covid-19 prevention behavior in pregnant women with a p-value (0.032) <0.05. Efforts are needed to increase awareness of pregnant women regarding the prevention of Covid-19 both during antenatal service and by developing education through various information media.
ANALISIS RISIKO STUNTING TERHADAP POLA ASUH PADA BALITA DI WILAYAH KERJA PUSKESMAS SIAK KABUPATEN SIAK
Authors: Ramadhani Masyitha , Novera Yenita Riski
Published: August 2022

The prevalence of stunting in Siak Regency reached 21.0%. Prevalence of stunting becomes a public health problem if it reaches 20% and needs to be handled before it increases. The general understanding in alleviating stunting is to focus on health efforts which are risk factors. Whereas risk factors are strongly influenced by protective factors including parenting / family. Stunting will have an impact not only physically, but also on cognitive function. This study aims to determine whether there is a relationship between feeding parenting and the incidence of stunting. The research design used is quantitative with a cross sectional analytic survey. The research subjects were mothers who had stunted toddlers aged 24-59 months, namely 49 respondents who were the case group, and 49 non-stunted toddlers who were the control group using total sampling. Data analysis used was Chi-square statistical test with a significance level of 0.05. The results of the relationship test showed that p-value = 0.000 (p <0.05), then there was a relationship between feeding parenting (democratic, authoritarian, permissive, and neglectful) with the incidence of stunting.It is recommended for puskesmas officers that the results of this study can be used as guidelines for providing counseling on good maternal behavior in preparing food and collaborating with relevant agencies that can help improve nutrition for children under five.
La aplicación de la cultura compliance como beneficio en el sector público del Ecuador
Authors: Torres-Rivera Rosa Catalina , Quevedo-Barros Manuel Rafael , Reyes-Cárdenas Narciza Azucena , Ochoa-Crespo Juan Diego
Published: August 2022

La cultura compliance requieren de una adecuada investigación, por lo cual se efectúa una revisión bibliográfica de autores, los cuales sustentan los fundamentos teóricos y legales derivados de estudios científicos y revisión documental. El objetivo fue analizar la aplicación de la cultura compliance como beneficio en el sector público del Ecuador. La investigación fue cualitativa, documental, histórico y de método explicativo, con el objetivo de contestar las interrogantes planteadas y resolver el problema identificado. Del análisis ejecutado, se puede concluir que existe la necesidad en el sector público de aplicar este nuevo sistema como herramienta de control de riesgo debido a que nos permite conocer la vulnerabilidad de las actividades de las instituciones públicas que de acuerdo con ellas se realiza el enfoque preventivo de la tal manera de ser utilizada como instrumento en la toma de decisiones de manera eficiente, realizando su respectiva revisión de los factores de riesgos.
Violación de los derechos humanos en Latinoamérica
Authors: Arana-Tacuri Génesis Lisette , Prieto-Reinoso Manuel Santiago , Coello-Méndez Jenyffer Mariela , Atencio-González Rously Eedyah
Published: August 2022

Violación de los derechos humanos en Latinoamérica
Políticas públicas educativas desde el marco constitucional ecuatoriano
Authors: Chavarría-Mendoza Carlos Alberto , Morales-Loor Julia Raquel , Cañarte-Mantuano Luis Oliverio , Chávez-Castillo José Enrique
Published: August 2022

El objetivo general de la presente investigación fue analizar las políticas públicas educativas desde el marco constitucional ecuatoriano. Se desarrolló desde el paradigma positivista y desde la perspectiva cuantitativa, mediante la búsqueda, recolección y análisis crítico documental, referencial bibliográfico desde la exégesis sobre las políticas públicas educativas desde el marco constitucional ecuatoriano, en este sentido, desde un diseño bibliográfico de tipo documental, el investigador realizó un proceso investigativo en donde la población de estudio, se fundamentó básicamente en documentos escritos como normas, leyes, para indagar los escritos relacionado al tema tratado, se consideró el análisis de contenido de la información recopilada, lo que permitió la formulación de resultados. Se apoyó el método analítico–sintético. Se concluye que para un mayor desempeño de la aplicación de las políticas públicas en la educación del Ecuador es importante contar con el talento humano calificado. (Docentes con especialidades vinculadas a las cátedras que imparten).
Derecho de propiedad intelectual sobre los medicamentos en tiempos de Covid-19
Authors: Plaza-Benavides Betzabeth Raquel , Pareja-López Odalis Anahí , Valverde-Burgos Nohely Sofía , Atencio-González Rously Eedyah
Published: August 2022

Derecho de propiedad intelectual sobre los medicamentos en tiempos de Covid-19
Auditoría forense en la detección de actos de corrupción en Ecuador durante la emergencia sanitaria
Authors: Angüisaca-Dutan Joselin Andrea , Quevedo-Barros Manuel Rafael , Ochoa-Crespo Juan Diego , González-Rodríguez Ramiro Oswaldo
Published: August 2022

El artículo tiene el propósito de conocer el impacto de la auditoría forense en la detección de actos de corrupción en el Ecuador durante la emergencia sanitaria. La exploración documental–bibliográfica surge de los elementos teóricos utilizados para valorar la aplicación de la auditoría forense durante la emergencia sanitaria en el país. Se revisó la producción científica de otros autores, se tomó información de portales oficiales como la Fiscalía y Contraloría General del Estado, con la finalidad de determinar una línea de investigación. Del análisis realizado se puede deducir, que los entes encargados de mitigar la corrupción han tomado acciones de control ante la emergencia sanitaria haciendo uso de herramientas y técnicas que provee la auditoría forense. Se concluye que todavía hay un largo camino por recorrer para luchar contra la corrupción, especialmente en casos relacionados con la emergencia sanitaria provocada por el COVID-19.
Reinserción familiar y social de personas privadas de libertad con beneficios penitenciarios
Authors: Lazo-Enríquez Miriam Nataly , Urgiles-León Sandra Jackeline , Herrera-Hugo Blanca-de-los-Ángeles
Published: August 2022

El objetivo se basó en conocer la situación familiar y social de aquellas personas que fueron privadas de libertad y quienes al cumplir un porcentaje de su pena impuesta previo a un proceso de análisis interno y cumplimiento de requisitos institucionales acceden a un beneficio penitenciario y nuevamente retornan a su realidad fuera de un Centro de Privación de Libertad. Con toda la información recabada se interpretó y analizó en base a nuestra realidad, desde una perspectiva crítica, considerando importante aportar con soluciones que contribuyan a una reinserción social positiva de todas aquellas personas que acceden a los beneficios penitenciarios, caracterizada por la acción-reflexión, determinando el contexto social al que retorna una persona privada de la libertad, y su transformación en su nuevo entorno.
Perfil del bachillerato ecuatoriano en la designación de los abanderados, portaestandartes y escoltas
Authors: Bustamante-Romero Ángel Andrés
Published: August 2022

El perfil del bachillerato ecuatoriano al ser considerado como finalidad del sistema educativo, todas las políticas educativas deben fundamentarse sobre él, por consiguiente, la investigación se planteó evaluar el cumplimiento del perfil en la designación de abanderados, portaestandartes y escoltas en estudiantes del tercer año de bachillerato de la Unidad Educativa José Ángel Palacio de la provincia de Loja, Ecuador. El estudio fue tipo descriptivo, trabajó con 11 docentes y 25 estudiantes con aplicación de dos instrumentos. Se obtuvo que, la elección de las dignidades no considera al perfil y que el 67% de los puntajes máximos sobre el logro de valores y del Sumak Kawsay corresponde a estudiantes comunes y el 33% restante a las dignidades estudiantiles. En consecuencia, se determina que el proceso de designación no guarda coherencia con el perfil y que existe inconsistencias entre lo enunciado en documentos oficiales con la realidad de la práctica educativa.
Learning English for specific purposes among members of the Shuar Musap Community
Authors: Vintimilla-Coronel María Verónica , Vega-Auquilla Melita Vanessa
Published: August 2022

Ecuadorian Amazonian communities play a leading role in calling foreigners to experience their beautiful landscapes and the uniqueness of their traditions; therefore, it is important for their inhabitants to be able to communicate with the English-speaking tourists who visit them. Through a mixed methods approach using questionnaires and interviews, the present study aimed to determine perceptions of English for Specific Purposes (ESP) learning within the framework of Andragogy principles among the Musap Shuar community. The findings of the study show favorable perceptions and high motivations regarding English language learning among adults in the community, making them ideal candidates for ESP learning within the framework of Andragogy. Implications for future research and implementation in other communities engaged in community-based tourism are included.
CLIL in use: perceptions and experiences of English teachers in public schools
Authors: Villamarín-Guevara Jorge Enrique , Fajardo-Dack Tammy
Published: August 2022

This study analyzes the perceptions and experiences that English teachers who work This study analyzes the perceptions and experiences of English teachers working in public institutions in the province of El Oro about the CLIL methodology, from its knowledge to its application. We worked with a descriptive type of research. It was determined that CLIL is not widely known or used among English teachers in the province of El Oro, despite being included in the National English Curriculum, which could be due to the lack of adequate training. Participating teachers who reported applying CLIL in the classroom recognized the innovative nature of the methodology. Therefore, they recommend CLIL as the most appropriate methodology for teaching English, although considering adaptations that could improve it, both in the materials used and in the use of additional resources, especially technological tools.
Teaching English vocabulary and online games to eighth grade students
Authors: Pintado-Peñaloza Katy Jackeline , Fajardo-Dack Tammy
Published: August 2022

The objective is based on exploring the impact of the use of online educational games in comparison with traditional classroom methods to teach English vocabulary to eighth grade students at Mercedes Vázquez Correa School. Quantitative approach with a participation of 13 students. By means of a vocabulary retention test, results were obtained showing that students remember a greater amount of vocabulary by means of traditional methods; however, students remember a greater amount of words accurately with the use of online games. In addition, the survey data reveal that students are comfortable with online games and that they prefer to learn vocabulary through online games rather than through drawings or flashcards in class.
Los derechos y garantías constitucionales en Ecuador
Authors: Ronquillo-Riera Orlando Iván , Borbor-Palacios Freddy Alejandro , Montúfar-Álvarez Carlos Antonio
Published: August 2022

El objetivo general de la presente investigación fue analizar jurídicamente los derechos y garantías constitucionales en Ecuador. Se desarrolló desde el paradigma positivista, atendiendo los lineamientos, fundamentados en una investigación descriptiva desde la perspectiva cuantitativa la cual produce datos descriptivos, apoyado en una investigación documental-bibliográfica.  También, se aplicó el método inductivo-deductivo, el cual propone que para descubrir una verdad se deben buscar los hechos y no fundamentarse en meras especulaciones. Además, el método analítico-sintético por medio del cual, se descompone un todo en partes extrayendo cualidades, componentes, relaciones y más para posteriormente unir las partes analizadas. El manejo de estos métodos hizo viable que se analicen doctrinas, cuerpos normativos, documentos jurídicos, bibliografía, trabajos arbitrados, la cual luego del análisis pertinente, permitió que se generen criterios. Se concluye que los derechos y garantías constitucionales en Ecuador, se encuentra tipificado en la Constitución de la República, es recomendable su promoción y difusión pública.
Métodos lúdicos para la adquisición de la noción del tiempo en niños con altas capacidades
Authors: Esteves-Fajardo Zila Isabel , Alcívar-Olvera Mainer Gregorio , Paredes-Menéndez Guadalupe Elizabeth , Estrella-Acencio Lidia Patricia
Published: August 2022

El objetivo general de la presente investigación fue describir los métodos lúdicos para la adquisición de la noción del tiempo en niños con altas capacidades. Cuya metodología se apoyó desde el enfoque cuantitativo, documental bibliográfico, de tipo descriptivo. En el cual se estableció una búsqueda, revisión metódica, rigurosa y profunda de trabajos arbitrados y tesis relacionadas al tema de estudio lo que contribuyó al desarrollo de la indagación. Se planteó además el método analítico-sintético, además se empleó la técnica de análisis de contenido, para relacionar las ideas más resaltantes con respecto a la lúdica, adquisición de la noción del tiempo y niños con altas capacidades. Se concluye que el juego representa una destreza que forma parte de la vida de todo ser humano, engrandece e incrementa su experiencia, contribuye a conferir sentido y significado a las actividades diarias. Abarca lo cognitivo, lingüístico, lógico, artístico, social y cultural contribuyen al desarrollo.
Estrategia para la optimización del cuidado de la enfermería en el Ecuador
Authors: Robles-Calle Verónica Jessenia , Tigua-Pareja Patricia Mercedes , Macancela-Orellana Marcia Beatriz , Sumba-Chuqui María Mercedes
Published: August 2022

El objetivo general de la presente investigación fue describir la estrategia para la optimización del cuidado de la enfermería en el Ecuador. El equipo de investigadores se planteó como metodología para la presente investigación, el paradigma positivista desde el enfoque cuantitativo, manejando la recolección y análisis desde el apoyo documental-bibliográfica, así mismo, se utilizó conjuntamente, el método analítico-sintético por medio del cual, se descompone un todo en partes extrayendo cualidades, componentes, relaciones y más para posteriormente unir las partes analizadas. Desde una exploración y reflexión detallada de textos, trabajos arbitrados y tesis, se lograron los datos necesarios para el desarrollo teórico y las conclusiones respectivas. Se concluye que, las diferentes estrategias que se implementan en la optimización del cuidado de la enfermería, constituyen herramientas para garantizar un servicio de calidad a los pacientes que acuden a los centros de salud, así mismo como el autocuidado del personal de la salud.
Los derechos humanos para una cultura de paz en instituciones de educación universitaria
Authors: Esteves-Fajardo Zila Isabel , Pizarro-García Yesenia Isabel , Jurado-Ronquillo Marivel Concepción , Parrales-Baidal Fanny Virginia
Published: August 2022

La presente investigación asumió como objetivo general analizar los derechos humanos para una cultura de paz en instituciones de educación universitaria. Se desarrolló desde el paradigma positivista, se basó en la perspectiva cuantitativa, con apoyo documental-bibliográfico, mediante la revisión de la información contenida en los datos obtenidos en los trabajos científicos arbitrados y tesis de grado relacionados al tema de estudio. En cuanto a la técnica de interpretación de la indagación, se consideró el análisis de contenido de la información recopilada, lo que permitió la formulación de resultados. Entre los resultados se consideró que el respeto a los derechos humanos forma parte de la gestión de la cultura de paz y que por medio de la educación se deben propiciar las estrategias necesarias para su desarrollo y difusión a nivel universitario. Es necesario promover la educación de calidad, eficiente y motivada desde los derechos humanos para una cultura de paz.
Impacto económico en la gestión pública del uso racional de medicamentos
Authors: Quito-Esteves Arlette Camila , Eguez-García Katya Gabriela , Iturralde-Avilés Manuel Eduardo , Fabre-Morales Erick Josué
Published: August 2022

El objetivo general de la presente investigación fue analizar impacto económico en la gestión pública del uso racional de medicamentos. Se desarrolló desde la perspectiva cuantitativa, mediante la búsqueda, recolección y análisis crítico documental, referencial bibliográfico y estudios de investigación, la misma fue de diseño no experimental; dado que, los investigadores diagnosticaron la situación actual del impacto económico en la gestión pública del uso racional de medicamentos. Apoyado, además en un diseño bibliográfico de tipo documental, la población de estudio se fundamentó básicamente en documentos escritos. Entre los hallazgos de la investigación se comprobó que la situación actual acerca del uso racional de medicamentos en los pacientes hospitalizados en la unidad de terapia intensiva es deficiente debido a que no manejan adecuadamente los procesos administrativos, por lo tanto, es esencial la gestión del talento humano y lograr disminuir el impacto económico en la gestión pública del uso racional de medicamentos.