bluuebunny/crossref_metadata_2025 huggingface dataset:
The antiplatelet therapeutical strategies in dependance on the VEGF-A gene G634C polymorphism in patients with acute myocardial infarction with ST segment elevation after successful PCI
Authors: Kutia Inna
Published: June 2020

The aim of the study was to evaluate the associations between the polymorphism G634C (rs 2010963) of the VEGF-A gene and the level of STEMI biomarkers with double antiplatelet therapy.

Materials and methods. 135 patients were enrolled in the case-control study, including 109 (80.7%) men and 26 (19.3%) women, the average age was 59.21 ± 8.92 years. The control group consisted of 30 healthy individuals. Primary percutaneous coronary intervention (PCI) using bare-metal coronary stent (BMS) was performed in 109 patients, 31 patients underwent systemic thrombolysis. The coronary blood flow was restored at the TIMI ІІІ level. Ultrasound examination of the heart was carried out on 3-5 days of hospitalization and after 6 months of observation. The study of the G634C allelic polymorphism (rs 2010963) of the VEGF-A gene was carried out by the method of polymerase chain reaction (PCR) in real time using the Syntol reagent kit (Russia). The level of VEGF-A was determined on the first day of the disease and after 6 months by enzyme immunoassay using reagents IBLINTERNATIONAL, GMBH, (Germany). Patients were divided into two groups: the first one was “case” group - patients who reached the end point, and the second group was “control” - did not reached. The combined endpoint was defined as: cardiovascular death, recurrent myocardial infarction, the occurrence / progression of heart failure that required hospitalization.

Results. The left ventricular ejection fraction (p = 0.002) and creatinine clearance (p = 0.018) were significantly lower in the case group, the diastolic dysfunction E/E 'was higher in the control group (p = 0.007). The level of VEGF-A is significantly lower in the “case” group, in this group there was a higher frequency of the 634GC + 634CC polymorphism of the VEGF-A gene (p = 0.035). The frequency of treatment with clopidogrel was higher in the case group (p = 0.031), and ticagrelor was more often prescribed in the control group (p = 0.031). Logistic uni-and multivariate analysis showed that independent predictors of adverse events after STEMI were polymorphism 634GC + 634CC of the VEGF-A gene, ejection fraction <50.60% and the clopidogrel antiplatelet therapy in the group of the polymorphic variant of the VEGF-A gene.

Conclusions: The presence of the 634GC + 634CC polymorphism of the VEGF-A gene, ejection fraction <50.60% and the clopidogrel treatment are independent predictors of adverse events in STEMI patients. The administration of ticagrelor against clopidogrel significantly benefit the course of the post-infarction period in patients with STEMI after successful PCI.
Chrystocentryczny wymiar postu i umartwienia w pismach św. Hieronima ze Strydonu
Authors: Sienkiewicz Edward Jan
Published: June 2020

Hieronim ze Strydonu, przedstawiany jest najczęściej jako wielki egzegeta i znawca oraz tłumacz Pisma Świętego. Niekiedy przypomina się również o jego znaczących dokonaniach w sporach teologicznych. Tymczasem sam Hieronim w swoich licznych pismach i działaniach, przedstawia się sobie współczesnym i potomnym jako bardzo wymagający od siebie i od drugich asceta. Praktykując mniszy styl życia na pustyni i poświęcając się pracy naukowej, dążył do jak najlepszego poznania Jezusa Chrystusa, aby Go jak najlepiej naśladować i przez swoje osobiste doświadczenia z Nim się jednoczyć. Dlatego też te dwie drogi, czyli studium Biblii oraz pokutę i wyrzeczenie, uznaje za najlepsze w tym celu. Poza tym – jak często podkreśla – wzajemnie się warunkujące i wspomagające. W jego teologii ascetycznej do głosu dochodzą tematy związane z zasługującym charakterem chrześcijańskiego umartwienia. Podstawę tego Strydończyk dostrzega w swoim bardzo wyraźnym wychyleniu eschatologicznym. Stanowi ono podstawowe kryterium w określaniu przez niego marnością wszystkiego co doczesne ze względu na to co wieczne i duchowe. Chrystocentrycznie rozumiana przez niego idea Królestwa Bożego, obecnego już w doczesności, staje się najważniejszym argumentem w wymaganiu od chrześcijan życia właściwego pełnej realizacji tej rzeczywistości w niebie. Najlepiej temu służy – w jego przekonaniu – wyrzeczenie aż po ofiarę z własnego życia. Najlepiej zaś to tłumaczy taka właśnie droga Zbawiciela, wzywającego do wspólnego z Nim życia w chwale nieba, przez wspólne z Nim umartwienie na ziemi.
NETWORK LATENCY COMPENSATION APPROACHES FOR APPLICATIONS IN 2030 COMMUNICATIONS NETWORKS
Authors: Gallyamov D. , Kisel V. , Kirichek R. , Borodin A. , Koucheryavy A.
Published: June 2020

Research subject. Communication network architecture 2030, delay compensation mechanisms. Objective. Consider the architecture of communication networks with intelligent edge computing, propose mechanisms for compensating network latency for tactile Internet applications based on predictive analytics. Core results. Scientific publications and specifications from open sources were analyzed, on tactile Internet topics, delay compensation mechanisms, intelligent boundary computing. A model of 2030 network architecture and a method of minimizing delay based on machine learning are proposed. Main conclusions. Modernization of the network architecture and software package will significantly increase the efficiency of communication networks, implement new models and methods of data processing, and will also have a significant impact on the digital economy.
THE DENSE OF DEVICES ANALYSIS FOR 5G NETWORKS
Authors: Tonkikh E.
Published: June 2020

Research subject. The article is devoted to the analysis of the characteristics of the density of devices in fifth-generation telecommunication networks. The characteristics of the density of devices and their influence on the structure of fifth-generation telecommunication networks are considered. Method. System analysis. Core results. The scientific tasks in the field of building highdense and ultra high-dense telecommunication networks of the fifth generation and subsequent are determined. Practical relevance. The results of the article can be used by scientific and design organizations when planning the development of telecommunication networks, as well as universities in the educational process.
FUNCTIONAL PURPOSE OF THE LOAD BALANCER IN CLOUD MICROSERVICE ARCHITECTURES
Authors: Elagin V. , Nikolaev V.
Published: June 2020

Scalability is a fundamental characteristic of any cloud-based microservice architecture. In the modern world, any service that is designed to provide services to a wide number of consumers should be characterized by good scalability and fast response speed. Potential users will never want to suffer constant errors, lost requests, denial of service, and other problems associated with a lack of service performance. Research subject: load balancing system in query processing and interaction within the cloud microservice architecture. Method: implementing additional elements in the cloud microservice architecture to provide load balancing. Core results: a number of popular load balancing algorithms in cloud microservice structures are compared, and options for upgrading in cloud microservice architectures for traffic balancing at different levels of the OSI model are proposed. Practical relevance: the study solved the problem of increasing the volume of processed requests without using a proportional increase in hardware resources.
Зв’язок окремих компонентів антифосфоліпідного синдрому з різними типами ремоделювання лівого шлуночка в пацієнтів з післяінфарктним кардіосклерозом та артеріальною гіпертензією
Authors: Nazarova M. S. , Stanislavchuk M. A. , Burdeina L. V.
Published: June 2020

The aim – to establish the features of left ventricular myocardial remodeling in men with postinfarction cardiosclerosis and to evaluate its relationship with the components of the antiphospholipid syndrome.Materials and methods. 164 patients with stable coronary heart disease and postinfarction cardiosclerosis were examined (100 % male, 53.0±9.14 years). The total antiphospholipid antibodies (aPL) to cardiolipin, phosphatidylserine, phosphatidylinositol, antibodies to β2-glycoprotein 1 (anti-β2-GP1) IgG and IgM classes were determined by ELISA. Echocardiography was performed by conventional methods, the type of left ventricular (LV) geometry was determined according to Ganau.Results and discussion. Positive levels of aPL and anti-β2-GP1 IgG were detected in 56.7 % of patients, including 33.5 % – double positivity for these antibodies. Positivity for aPL and anti-β2-GP1 IgG was associated with more significant echocardiographic signs of LV systolic and diastolic dysfunction. Among patients with positive levels of aPL and anti-β2-GP1 IgG LV hypertrophy were higher (2.5–3.0 times, p<0.05) than among patients with negative antibody levels. Increased levels of anti-β2-GP1 IgG were found to be an independent predictor of increased LV myocardial mass index (β=0.344, p<0.0001) in men with postinfarction cardiosclerosis.Conclusions. In men with postinfarction cardiosclerosis who had positive levels of aPL and anti-β2-GP1 IgG, associated with the development of systolic and diastolic dysfunction and with a higher risk of maladaptive LV remodeling.
CONSTRUCTING THE VISUAL LANGUAGE OF 19TH CENTURY CELEBES SEA REGION MARITIME CULTURE THROUGH CONCEPT ART
Authors: Aditya Christian
Published: June 2020

In order to create a believable world for the animated content. Concept art for the animation are created through the process of studying literatures about Celebes Sea maritime history and field observation on Celebes Sea region. In this paper, the concept art being discussed is limited to the environment of the animated world along with some of Its property such as houses and boat, however there are minimum visual data on related literature and unmaintained artifacts / model from field observation. There- fore, visual language has to be decoded through historical text in the literature and also through visual research on available artifacts / model of the property. The concept art development is still an ongoing process.
PENERAPAN STORYBOARD DALAM VIDEO IKLAN LAYANAN MASYARAKAT “DIET PLASTIK”
Authors: Ferdinanda Ferdinanda , Pertiwi Elianna Gerda
Published: June 2020

Plastic is one material that is often used by humans for various things, such as bags of groceries to food packaging. Plastic is a popular material used in common be- cause it is considered practical. On the other side, plastic also harms the environment if it is not used, because of the nature of the plastic that is difficult to decompose even though it has buried for decades. The increase in plastic waste that sourcing from daily activity needs to address immediately; one of them is through socialization and exposure to the public on the importance of reducing plastic waste. Public Service Announcements (PSA) are quite useful in informing an appeal to the public because they place more emphasis on the public interest that seeks to in-still awareness about the social issues in circulation. PSA can implement through information media such as newspapers, radio, posters to multimedia such as audio-visual media, which are increasingly popular these days due to the rapid development of Information and Communication Technology (ICT). In designing PSA, one of the stages that needs to be done is the creation of storyboards in the pre-production stage. The storyboard contains technical indicators such as picture descriptions, cameras, lighting and supporting properties visualized in the sketch. The suitability and the smooth production of advertisements or cinema are very dependent on the preproduction stage, one of which is the creation of storyboards.
Peningkatan Kemampuan Menghitung Pecahan Melalui Pembelajaran CTL Di MI Negeri Peureulak
Authors: Auliyani Fitri , Husna Asmaul , Tatsa Nur Arifah , M. Nur Yusaini
Published: June 2020

Pembelajaran matematika pada sekolah dasar hendaknya menggunakan beberapa strategi pembelajaran, tujuannya adalah untuk memudahkan proses belajar mengajar. Berdasarkan hasil observasi awal pada kelas IV MIN Peureulak menunjukkan bahwa siswa tidak mampu menghitung pecahan yang berpenyebut sama dan pecahan berpenyebut beda. Penggunaan strategi CTL ini bertujuan untuk meningkatkan kemampuan menghitung siswa dan untuk mengetahui aktivitas yang dilakukan siswa khususnya pada materi pecahan di kelas IV MIN Peureulak. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK), dilaksanakan sebanyak dua siklus pada siswa kelas IV/A. Instrumen yang digunakan untuk memperoleh data dalam penelitian ini adalah tes dan observasi. Data dianalisis dengan menggunakan rumus persentase. Hasil penelitian menunjukkan bahwa terjadi peningkatan terhadap tingkat ketuntasan hasil belajar siswa secara klasikal pada siklus I berjumlah 42%. Pada siklus II meningkat mencapai 77%, serta terjadi peningkatan terhadap aktivitas belajar siswa yaitu pada siklus I berjumlah 73% dan pada siklus II meningkat mencapai 87%. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa penerapan strategi pembelajaran CTL dapat meningkatkan kemampuan menghitung pecahan siswa serta dapat meningkatkan aktivitas belajar siswa pada materi pecahan di kelas IV/A MIN Peureulak.
PENGARUH BEBERAPA MEDIA SEMAI TERHADAP PERTUMBUHAN STEK AKAR TANAMAN SUKUN (Aartocharpus communis forst)
Authors: Nursida. Zinatal Hayati Rofika Nofri Yandra.
Published: June 2020

Penelitian pengaruh beberapa media semai terhadap tumbuhan stek akar tanaman sukun telah dilaksanakan di green house fakultas pertanian jl.lintas provisi tembilahan barat kematan tembilahan hulu selama 4 bulan (mei-agustus). Penelitian ini untuk mengahtahui pengaruh beberapa kombinasi media semai terhadap pertumbuhan stek akar tanaman sukun dan untuk mengetaui kombinasi media yang cocok untuk pertumbuhan stek akar sukun.

Rancangan penelitian ini menggunakan rancangan acak kelompok dengan enam perlakuan yang terdiri dari kombinasi pasir dan pupuk kandang (2 :2 :1), pasir. Pupuk kandang dan tanah gambut 1 :1 :1, pasir pupuk kandang dan serbuk gergaji 1 :1 :1, pasir pupuk kandang dan arang serbuk gergaji 1 :1 :1, pasir, pupuk sekam padi 1 :1 :1, keenam perlakuan diulang sebanyak 3 kali parameter yang di amati oada peneliyian ini adalah panajng tunas, panjang daun, jumlah daun, diameter tunas, persentase tumbuh, persentase hidup, jumlah akar bobot akarkering dan indiks mutu bibit.

Hasil sidik ragam yang diuji pada f tabel 5% menunjukkan pengaruh yang nyata pada jumlah akar bobot akar kering dan indeks mutu bibit dan pengaruh yang tidak nyata pada para meter panjang tunas. Panjang daun, jumlah daun, diameter tunas persentasi tmbuh dan persentasi tumbuh.

 

Kata kunci: sukun,Media, Stek
PRODUKTIVITAS PUPUK ORGANIK TERHADAP HASIL TANAMAN JAGUNG (Zea mays L) DI TANAH MINERAL
Authors: Yoyon Riono.
Published: June 2020

Penelitian tentang pengaruh pemberian produktivitas pupuk organik terhadap hasil Tanaman Jagung (Zea mays L) di tanah mineral penelitian ini di laksanakan pada bulan Februari sampai Mei, yang bertempat di Sungai Salak Kecsmstsn Tempuling Kabupaten Indragiri Hilir Provinsi Riau.

Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) yang disusun secara faktorial yang terdiri dari 2 faktor dan 3 ulangan. Faktor B adalah bokashi pupuk kandang yang terdiri dari 4 taraf yaitu B0 (tanpa pemberianpupuk kandang), B1 (5 ton/ha) dan B2 (10 tom/ ha), serta B3 (15 ton/ha)

Parameter yang di amati adalah tinggi tanaman, panjang daun ke tujuh, berat brangkasan basah, berat berangkasan kering, berat tongkol pertanaman sampel, diameter tongkol , produksi per plot, dan berat 100 biji. Selanjutnya data yang di peroleh di olah secara statistik, apabila F hitung lebih besar dari F tabel di lanjutkan dengan uji lanjut Tukey HSD pada taraf 5%.

Hasil penelitian menunjukan bahwa interaksi bokashi pupuk kandang dan varietas berpengaruh nyata terhadap berat tongkol dan produksi dan produksi per plot, akan tetapi tidak berpengaruh nyata terhadap tinggi tanaman, panjang daun ke tujuh, berat brangkasan basah, berat brangkasan kering , diameter tongkol dan berat 1000 biji. Untuk perlakuan bokashi pupuk kandang secara tunggal berpengaruh nyata terhadap terhadap diameter tongkol , akan tetapi tidak berpengaruh nyata terhadap tinggi tanaman, panjang daun ke tujuh, berat brangkasan basah, berat brangkasan kering, berat tongkol, produksi per plot, dan berat 1000 biji, perlakuan bokashi terbaik terdapat pada pemberian 15 ton/ha. Sedangkan perlakuan varietas secara tunggal berpengaruh nyata terhadap berat brangkasan basah, berat tongkol, dan produksi per plot seta berat 1000 biji, akan tetapi tidak berbeda nyata dengan tinggi tanaman, panjang daun ke tujuh, berat brangkasan kering, dan diameter tongkol. Varietass terbaik adalah NT 10
Afetlerde Özel Gereksinimli Grup Olarak Yaşlılar
Authors: ÇAKIR Özlem , ATALAY Gülseren
Published: June 2020

Dünya nüfusu yaşlanırken bir sosyal politika aracı olarak yaşlı politikaları özel önem atfedilen konular arasında yerini almaktadır. Birleşmiş Milletler Teşkilatının İnsani Gelişme Raporları toplumda çocuklar ve engellilerin yansıra yaşlıların da afetlerde ve iklim değişikliği sonucu ortaya çıkan risklerden etkilenen en kırılgan gruplar olduğunu vurgulamaktadır. Yaşlı bireyler kronik hastalıkları, fiziksel engelleri, işitme ve görme kayıpları nedeniyle, normal yaşamlarında özel ihtiyaçlarını karşılarken yardıma gereksinim duyabilmektedir. Afet-acil durumlarda örneğin sıcak ve soğuk hava koşulları ile salgın hastalık durumları kronik hastalığa sahip yaşlı bireylerin sağlık durumunu kötüleştirmekte, hayatlarını tehdit etmekte özel olarak korunması gereken nüfus kesimini oluşturmaktadırlar. Afet riskleri altında diğer bireylere göre daha savunmasız ve kırılgan olduklarından, acil durum ve afetlerde hazırlık, afetler sırasındaki müdahale ve afet sonrası yardım mekanizmalarında yaşlılar ülkemizde de özel olarak ele alınması gereken dezavantajlı gruplardan biri olarak karşımıza çıkmaktadır. Bu çalışmada yaşlı bireylerin kronik hastalıkları ve fiziksel engelleri, genç bireyler göre yavaş hareket etmelerine neden olan kırılganlıkları (hassasiyetleri) nedeniyle özel durumları karşısında geliştirilen önlemler, uygulamalar ve sonuçlarının Dünya örnekleri ışığında incelenmesi ve ülkemiz için öneriler geliştirilmesi amaçlanmıştır. Çalışmada Amerika Birleşik Devletleri, Japonya’da ve Avrupa ülkelerinde belirli acil durum ve afetlerde yaşlı gruplara yönelik gerçekleştirilen hizmetler, alınan önlemler ve kurumsal yapı örnekleri incelenmektedir. Konuya yönelik ülkemizde yerel yönetimlerin, merkezi ve taşra teşkilatlarının yaşlı hizmetlerinin acil durum ve afetlerde yaşlı-duyarlı afet yönetimi planlama süreçlerinin geliştirilmesine yönelik öneriler sunulmaktadır. Sonuç olarak afet yönetimi ile uyumlu bir sosyal politika zemini her açıdan yerel afet müdahale kapasitesini ve toplumun afete dirençliliğini arttıracaktır.
To study the effect of early versus late trophic feeding in preterm neonates with mild respiratory distress syndrome
Authors: Sinha Rahul , Venkatnarayan K , Dalal Shamsher , John B M , Syed V Sabid
Published: June 2020

Background: The respiratory distress syndrome in preterm neonates is mostly due to surfactant deficiency. The incidence and severity of respiratory distress syndrome are related inversely to the gestational age of the newborn infant. The early nutritional support, in these preterm neonates with respiratory distress, prevents complications, and maintains positive energy balance. Objective: The aim was to study the effect of early versus late trophic feeding in preterm neonates with mild respiratory distress syndrome. Materials and Methods: This was a prospective study conducted in babies admitted to neonatal intensive care unit (NICU) from January 2013 to January 2016 in Military Zonal Hospital. A total of 200 babies with a gestational age <37 weeks and birth weight between 1200 and 2000 g were evaluated and divided into the early and late group. In early group, the nutritional support in the form of expressed breast milk 15 ml/kg/day in preterm neonates with mild respiratory distress was given within 24 h of life and in late group after 48 h of life. Results: The early nutritional support in preterm neonates with mild respiratory distress decreases the requirement of oxygen and caffeine, helps to reach early full feeds, decrease in the incidence of necrotizing enterocolitis, early weight gain and early discharge from hospital. Conclusion: In our study findings, certainly suggest the benefits of early trophic feed compared to late in preterm neonates with mild respiratory distress. It seems that better education of mothers for expressing their milk and handing to NICU for use in trophic feeding is important. However the large randomized controlled trial is required to validate the above findings.
Congenital herpes infection: An unusual presentation
Authors: Mina Shyam Sundar , Eske Gunvant Singh , Kashyap Archana
Published: June 2020

Maternal genital herpes is a sexually transmitted infection, asymptomatic in 70% of cases. Mostly infection is acquired during intrapartum period or postnatally through contact with mucocutaneous lesions. Primary neonatal herpetic infection outside the oral cavity is uncommon, but there are well-documented ocular cases, with or without associated oral lesions. A high index of clinical suspicion is the key for early antiviral treatment initiation and better outcome.
Managing pearly prepuce - Active communication and masterly inaction
Authors: Faridi M M A , Sharma Ankit
Published: June 2020

Epstein pearls are small inclusion cysts and are found on the hard palate of the newborn infants in the early neonatal age. These may be present on the prepuce and are referred as prepucial Epstein pearl. Epstein pearls need no treatment but parental anxiety needs to be addressed by active communication and counselling.
A rare case of hemophilia with Ewing’s sarcoma - A case report
Authors: KV Urmila , Saifu Sanad
Published: June 2020

Malignancies are rare in children with inherited coagulation disorders like hemophilia except for non-Hodgkin’s lymphoma and liver malignancies in hepatitis C positive hemophiliacs. Ewing sarcoma of bone is the second most common primary malignant bone cancer in children and adolescents; particularly, the extra skeletal variety. There is limited data available in the literature reporting hemophilia with Ewing’s sarcoma. The authors report a case of 16-year-old boy with hemophilia A, who was diagnosed to have pelvic Ewing’s sarcoma, which is a rare occurrence. This case could have been mistaken for hemophilic pseudotumor because of the non-specific clinical presentation. Magnetic resonance imaging and open biopsy helped to arrive at a diagnosis. The patient is now being treated with chemotherapy and radiotherapy.
Repeat Registrations of a Running Event: Applying Customer Base Analysis
Authors: Finnegan Carol A. , Aicher Thomas J. , Block Robert A.
Published: June 2020

Abstract: While the running community has experienced tremendous growth over the past several decades, increased competition and plateauing participation rates have made effective race marketing an imperative. This study examined the repeat registration behavior of running event participants through the lens of Ehrenberg’s (1988) repeat-buying theory. We used Customer-Base Analysis on combinations of observed frequency and recency patterns in runner registrations over a seven-year period. Based upon registration data ( N = 26,625), we found that runners with the highest probability of registering for future races have run the race within the previous two years. Results from the current study offer insights about repeat purchase behavior of race participants that can help determine allocation of scarce marketing dollars.
An Assessment of Fans’ Willingness to Pay for Team’s Environmental Sustainability Initiatives
Authors: Greenhalgh Greg , Drayer Joris
Published: June 2020

Abstract: The current study aims to understand if sport organizations can utilize environmental sustainability (ES) efforts to increase revenue in addition to saving money. To do this, fans of the Philadelphia Eagles were surveyed. Findings indicate fans were willing to pay an average of US$6.50 in the form of a sustainability fee to help the organization implement an environmental initiative. Furthermore, this study found that nearly none of the prevailing thoughts on predictors of fan behavior significantly positively predicted fans’ willingness to pay an environmental sustainability fee. The findings of the current study challenge the conventional theoretical thinking with respect to fan behavior. Furthermore, respondents in the current study were equally likely to financially support the sustainability efforts of their favorite team no matter their income, loyalty to the team, personal values, or conative loyalty associated with environmental sustainability. Theoretically, the current study advanced the triple bottom line theory, the Contingent Valuation Model, and the Model of Sport Fan Sustainability Behavior.
Losing Weight with Charles and Dan: Examining Potential Liability for Endorser Claims in Weight Loss Advertisements
Authors: Brison Natasha T. , Pickett Andrew C. , Brown Katie M.
Published: June 2020

Abstract: The weight loss industry in America accounts for billions of dollars annually. Many products and programs are endorsed by sport celebrities and promote quick-fix (ineffective) remedies. As a result, these advertisements are often involved in investigations by the Federal Trade Commission (FTC) for false or misleading claims. Unfortunately, endorsers may not understand they can be held liable for these claims. Therefore, the purpose of this study was to examine the statements made by athletes that may give rise to potential liability for false claims in weight loss management advertising. A content analysis of weight loss management program advertisements featuring athletes was conducted ( N = 42) to determine the presence of deceptive or potentially misleading statements using FTC guidelines. Results demonstrate multiple potential FTC violations regarding false or misleading claims by athletes. In turn, the authors provide recommendations for sport celebrity endorsers regarding best practices for weight loss program endorsements.
La conoscenza inconscia del soggetto e il desiderio dell’analista nella clinica della droga
Authors: Rocha Lorena Fabiani da
Published: June 2020

L’assistenza clinica ai pazienti con farmaci richiede che si osservino le dimensioni inconsce del soggetto che farmaci e dell’analista di accompagnamento, considerando che queste dimensioni precedono e implicano la condizione di dipendenza del paziente. Pertanto, questo lavoro mira a chiarire le prospettive psicoanalitiche che guidano l’approccio del tossicomane nell’ambiente delle cure. Concetti come “inconscio” e “desiderio di analisi” sono stati presi al fine di chiarire come la situazione analitica costituisce un trattamento individualizzante e si oppone al metodo psichiatrico classico. Pertanto, si sottolinea l’esistenza di una particolare conoscenza in ogni paziente sulla sua tossicodipendenza, che non è stata prevista dalla nosologia medica. Pertanto, la tecnica psichiatrica è considerata insufficiente e viene esplorato un approccio che cerca di interpretare meglio la tossicodipendenza, avendo come strumento per basare il desiderio dell’analista. Oltre ai concetti centrali portati dal titolo, l’opera passa anche attraverso le nozioni di “linguaggio”, “malessere nella cultura”, “I”, “monomania”, “castrazione” e “maturazione di guida”. La ricerca è iniziata dal metodo di indagine bibliografica, riferendosi al tema “Dipendenza dalla droga” nell’ambito della psicoanalisi e della psichiatria classica. Fu usata la letteratura di autori consacrati che si incrociano con tale conoscenza, come Freud, Lacan e Bercherie.
La connaissance inconsciente du sujet et le désir de l’analyste à la clinique de toxicomanie
Authors: Rocha Lorena Fabiani da
Published: June 2020

Les soins cliniques aux patients toxicomanes exigent que les dimensions inconscientes du sujet qui médicamentent et l’analyste accompagnateur soient observées, considérant que ces dimensions précèdent et impliquent l’état de dépendance du patient. Ainsi, ce travail vise à clarifier les perspectives psychanalytiques qui guident l’approche du toxicomanphénomomenon dans le cadre des soins. Des concepts tels que “inconscient” et “désir d’analyste” ont été pris afin d’élucider comment la situation analytique constitue un traitement individualisateur et s’oppose à la méthode de psychiatrie classique. Par conséquent, il est souligné l’existence d’une connaissance particulière dans chaque patient au sujet de sa dépendance à la drogue, qui n’a pas été prédite par la nosologie médicale. Par conséquent, la technique psychiatrique est jugée insuffisante et une approche est explorée qui cherche à mieux interpréter la toxicomanie, ayant comme outil pour fonder le désir de l’analyste. Outre les concepts centraux apportés par le titre, l’œuvre passe aussi par les notions de “langue”, de “malaise dans la culture”, de “je”, de “monomanie”, de “castration” et de “maturation de la conduite”. La recherche a commencé à partir de la méthode d’investigation bibliographique, se référant au thème “Drug addiction” dans le domaine de la psychanalyse et la psychiatrie classique. La littérature d’auteurs consacrés qui croisent ces connaissances, comme Freud, Lacan et Bercherie, a été utilisée.
Protection by melatonin in respiratory diseases: valuable information for the treatment of COVID-19
Authors: Hardeland Ruediger , Tan Dun-Xian
Published: June 2020

High mortality rates in severe progression of COVID-19 are predominantly caused by pulmonary failure due to high-grade airway inflammation. As investigations on the efficacy of melatonin in this disease are still in their beginning, it may be worth-while to recall the body of evidence on protective effects in other respiratory dysfunctions, which have been studied pre-clinically and clinically. In various diseases and corresponding animal models, melatonin has been shown to be protective, mainly because of its anti-inflammatory and antioxidant properties. This was documented in pathologies as different as allergic airway inflammation, toxicologically or radiation-induced acute lung injury, respiratory disorders such as COPD, obstructive sleep apnea, neonatal respiratory distress syndrome, bronchopulmonary dysplasia and asphyxia, impaired respiration in sepsis, idiopathic pulmonary fibrosis, and pulmonary hypertension. The prevailing outcome has been protection or amelioration by melatonin, in conjunction with reduced expression and release of proinflammatory cytokines, such as IL-1β, IL-2, IL-6, IL-8, and TNFα, which was often explained by interference with toll-like receptors, inhibition of NLRP3 inflammasome activation and suppression of NF-κB signaling. In several studies, these beneficial effects were partially related to the upregulation of sirtuin-1 (SIRT1) by melatonin. The body of knowledge on melatonin’s efficacy in respiratory diseases is encouraging for the use of this powerful agent in COVID-19.
COVID-19 pathophysiology: interactions of gut microbiome, melatonin, vitamin D, stress, kynurenine and the alpha 7 nicotinic receptor: Treatment implications
Authors: Anderson George , Reiter Russel J
Published: June 2020

As data emerges on the pathophysiological underpinnings of severe acute respiratory syndrome coronavirus (SARS-CoV)-2, it is clear that there are considerable variations in its susceptibility and severity/fatality, which give indications as to its pathophysiology and treatment. SARS-CoV-2 modulatory factors include age, vitamin D levels, cigarette smoking, gender and ethnicity as well as premorbid medical conditions, including diabetes, cancer, obesity, cardiovascular disease, and immune-compromised conditions. A complex picture is emerging, with an array of systemic physiological processes interacting including circadian, immune, intestinal, CNS and coagulation factors. This article reviews data on SARS-CoV-2 pathoetiology and pathophysiology. It is proposed that a decrease in pineal and systemic melatonin is an important driver of SARS-CoV-2 susceptibility and severity, with the loss of pineal melatonin's induction of the alpha 7 nicotinic acetylcholine receptor (α7nAChR) in pulmonary epithelial cells and immune cells being a powerful regulator of susceptibility and severity, respectively. Stress, including discrimination stress, and decreased vitamin D also regulate SARS-CoV-2, including via gut dysbiosis and permeability, with a resultant decrease in the short-chain fatty acid, butyrate, and increase in circulating lipopolysaccharide. Stress and cytokine induction of the kynurenine pathways, leads to aryl hydrocarbon receptor activation, which primes platelets for heightened activity, coagulation and thrombin production, thereby driving elevations in thrombin that underpin many SARS-CoV-2 fatalities. On the basis of these pathophysiological changes, prophylactic and symptomatic treatments are proposed, including the use of melatonin and α7nAChR agonism.
The Effect of Learning Models and Academic Ability on Students’ Scientific Literacy in Disaster Preparedness
Authors: Widi Winarni Endang , Purwandari Endina Putri , Shofiya M. I. Rizqa Dwi , M. I. Shofiya
Published: June 2020

Scientific literacy is important for elementary students, especially for disaster preparedness issues. The research purpose was to analyze the effect of Problem Based Learning models and students’ academic abilities on scientific literacy in attitudes, contexts, competencies, and knowledge. The research method used a quasi-experimental with the matching only pretest-posttest control group design. The populations were 4 elementary schools with a disaster preparedness program. Samples were taken by cluster random sampling. The homogeneity test based on the average scores from odd semester 2018/2019 in fourth-grade elementary school for subjects such as civic education, mathematics, Indonesian language, science, and social sciences. The independent variable was thematic with PBL learning model. The moderator variable was a student’s academic ability and the dependent variable was scientific literacy which includes attitude, context, knowledge, and competence. Instruments in this study were attitude questionnaire, context and knowledge test, and science competency observation. Quantitative data were analyzed with IBM SPSS Statistics 25. The research experiments show that (1) PBL model has a significant influence on the student in scientific literacy aspects such as attitudes, contexts, knowledge, and competencies; (2) academic ability does not significantly influence the scientific literacy aspects. School principals, teachers, and future researchers suggested to download the information and make learning resources about earthquake disaster preparedness education on the www.wartabencana.com to foster earthquake safety culture for students optimally.
Pengenalan Computational Thinking Sebagai Metode Problem Solving Kepada Guru dan Siswa Sekolah di Kota Semarang
Authors: Sukamto Titien S. , Pertiwi Ayu , Affandy Affandy , Syukur Abdul , Hafidhoh Nisa'ul , Hidayat Erwin Yudi
Published: June 2020

Problem solving merupakan salah satu kemampuan yang sangat dibutuhkan untuk menghadapi persaingan global. Maka dari itu perlu untuk dilatih sedari dini. Melihat pada perkembangan teknologi dan imlu komputer, lahirlah sebuah pendekatan problem solving skill yang dikenal dengan nama Computational Thinking (CT). CT dikembangkan dari konsep dasar ilmu komputer, dengan cara mengabstraksi permasalahan kemudian mengilustrasikan dan menyusun solusi. Mulai tahun 2016, Indonesia secara aktif berpartisipasi dalam Komunitas Bebras dan mengkampanyekan Computational Thinking dengan mengadakan Bebras Challenge bagi siswa sekolah di seluruh Indonesia. Fakultas Ilmu Komputer UDINUS menjadi salah satu Bebras Biro yang ikut sebagai penyelenggara Bebras Challenge di Kota Semarang. Penyuluhan Bebras kepada Guru dimaksudkan untuk mengenalkan skill Computational Thinking ini, sehingga ke depannya setiap guru dapat menyampaikan dan melatih siswanya dalam pengembangan skill problem solving. Penyuluhan diikuti oleh guru perwakilan dari 27 sekolah dasar di Kota Semarang. Sebagai rangkaian kampanye, Bebras Challenge diikuti oleh total 169 siswa dari SD dan SMP di Kota Semarang. Hasil Bebras Challenge, terdapat 1 peserta asal Bebras Biro UDINUS yang berhasil masuk peringkat 3 besar nasional.
Up Grading Capacity Aparatur Desa Melalui Pelatihan di Desa Tegalarum Kabupaten Demak
Authors: Moeljono Moeljono , Alfiyanto Nasron
Published: June 2020

Kapasitas dan ketrampilan aparat desa dalam melaksanakan tugas administrasi dan tata kelola pelaporan keuangan masih lemah, untuk meningkatkan kapasitas dan ketrampilan para aparatur desa diperlukan adanya pelatihan, untuk meningkatkan kapasitas aparatur pemerintahan desa. Diharapkan melalui kegiatan tersebut akan mendorong tata kelola pemerintahan desa yang akuntabel dan transparan serta melahirkan aparatur desa yang memiliki pengetahuan, sikap dan keterampilan yang baik. Metode kegiatan yang digunakan adalah Participatory Learning and Action. Kegiatan ini dilakukan dengan menekankan pada kegiatan ceramah, diskusi, curah pendapat yang dilakukan secara interaktif dengan aparatur desa dan masyarakat, dilanjutkan dengan kegiatan pelatihan yang relevan dengan materi pemberdayaan masyarakat. Hasil kegiatan pengabdian masyarakat berjalan sesuai dengan rencana yang telah ditetapkan, aparatur desa dan masyarakat memilki respon dan antusias terhadap pelatihan dan tercipta perubahan pengetahuan, sikap dan keterampilan.
Workshop Praktek Pemberian Makanan Pendamping ASI (MP-ASI) bagi Baduta pada Kader Posyandu
Authors: Dwi Erma Kusumawati  , Ansar Ansar , Bahja Bahja , Fahmi Hafid
Published: June 2020

Stunting is a nutritional problem which its overcoming effort should be started from thousand days of early life. Age of 6 to 24 months is a golden life phase that when its nutritional fulfillment are insufficient, it will give a big impact for the future life. On this phase, the childs are started for recognition of breastmilk complementary food which its texture and amount are different based on the age. There are still many problems in Indonesia regarding the golden standard implementation of infant and child feeding such as Early Breastfeeding Initiation, Exclusive Breastfeeding, and Breastfeeding till 24 months or more.

Workshop using andragogy training technique in rilex but serious situation is expected to increase knowledge of training material. Workshop is conducted by utilizing the available space with group dynamics and games.

The results of public service activity with 24 cadres as participant showed that there are 20 cadres that increase their knowledge after attending workshop and there are 4 cadres that there is no change in knowledge. Wilcoxon test showed p value as 0.001. This is indicate that statistically there is a significant different of knowledge after attending workshop. The common child and infant feeding practice in our community is early complementary feeding with excuses that breastmilk is not enough to increase baby weight and food taboo such as forbidden for consumption of milk banana.
Pelatihan Pijat Oksitosin bagi Pendamping Ibu Nifas
Authors: Sumiaty Sumiaty , Muliani Muliani , Lisnawati Lisnawati
Published: June 2020

Inadequate milk production in the first days after delivery is caused by a lack of stimulation of the hormone prolactin and the hormone oxytocin. Decreasing milk production is caused by decreased stimulation of hormones prolactin and oxytocin. Efforts that can be made to stimulate the increase of hormone prolactin and oxytocin, including initiating early breastfeeding, expressing breast milk, and doing oxytocin massage, are practical and efficient in increasing milk production. Data from the Public Health Office of Palu in 2017 and 2018 showed that the average of exclusive breastfeeding coverage in 11 sub-districts in Central Sulawesi Province is <50% and specifically Kota Palu exclusive breastfeeding coverage only 49.6% in 2017 and then dropped to 49, 3% in 2018. Oxytocin massage training has never been conducted at the Tawaeli Community Health Center, especially for postpartum mothers companions such as Posyandu Cadres, Husbands, or Families. The method used in community service activities was discussions, simulations, and demonstrations using leaflet and audiovisual media. The number of puerperal mothers who attended the training was 25 people. The results of training activities for postpartum mothers in the Kayumalue Ngapa village obtained that the results of knowledge analysis overall increased in the knowledge of 25 participants after attending the training, with an average increase of 13 points. The p-value<0,001 results meant that statistically, there was a significant effect on the increase of knowledge of postpartum mothers companion after attending oxytocin massage training. To sum up that there is a significant increase in knowledge between before and after training on oxytocin massage in stimulating milk production. It is recommended that health workers need to be consistent and continuous in giving training to the companion of the postpartum mother (husband, family or cadre) in order to be able to assist the process of changing behavior for the postpartum mother to provide exclusive breastfeeding and conduct care during the postpartum period.
The Evaluation of Negative Factors of Direct Payments under Common Agricultural Policy from a Viewpoint of Sustainability of Rural Regions of the New EU Member States: Evidence from Lithuania
Authors: Morkunas Mangirdas , Labukas Povilas
Published: June 2020

The present study aims to determine and evaluate the negative consequences of the implementation of the direct payments financial support mechanism under the Common Agricultural Policy on the rural sustainability of Lithuania. Interviews of experts and a combination of the analytic hierarchy process with three different measurement scales and the analytic hierarchy process with triangular fuzzy numbers were employed in order to evaluate and rank the negative effects of the direct payments mechanism of the Common Agricultural Policy. It was revealed that high land prices, decreasing diversification of cultivated crops, land degradation, and financial indebtedness of farmers can be attributed to direct payments and these consequences have a significant negative impact on the rural sustainability of Lithuania. The necessity of using a combination of different evaluation scales and techniques was confirmed.
Genetic Characterization of the “Chusca Lojana”, a Creole Goat Reared in Ecuador, and Its Relationship with Other Goat Breeds
Authors: Aguirre-Riofrio Lenin , Maza-Tandazo Teddy , Quezada-Padilla Manuel , Albito-Balcazar Oscar , Flores-Gonzalez Alex , Camacho-Enriquez Osvaldo , Martinez-Martinez Amparo , Consortium BioGoat , Delgado-Bermejo Juan Vicente
Published: June 2020

The largest population of goats (62%) in Ecuador is in the dry forest region in the south of the country. A Creole goat, named “Chusca Lojana”, has adapted to the dry forest region where environmental conditions are warm-dry, with sparse vegetation. Knowledge of the genetic information of the Creole goat is important to determine intra-racial diversity, the degree of genetic distance among other breeds of goats, and the possible substructure of the population, which is valuable for the conservation of such a species’ genetic resources. A total of 145 samples of the Creole goat was taken from the four biotypes previously identified. Genetic analyses were performed using 38 microsatellites recommended for studies of goat genetic diversity (FAO-ISAG). The results of within-breed genetic diversity showed a mean number of alleles per locus (MNA) of 8, an effective number of alleles (Ae) of 4.3, an expected heterozygosity (He) of 0.71, an observed heterozygosity (Ho) of 0.63, polymorphic information content (PIC) of 0.67, and an FIS value of 0.11. Between-breed genetic diversity among 43 goat populations (native of Spain, American Creole, Europeans, and Africans) showed the following values: FIS = 0.087, FIT = 0.176, and FST = 0.098. Regarding the analysis of the population structure, the results showed that the Creole Chusca Lojana goat population is homogeneous and no genetic separation was observed between the different biotypes (FST = 0.0073). In conclusion, the Chusca Lojana goat has a high genetic diversity, without exhibiting a genetic substructure. Therefore, it should be considered as a distinct population because crossbreeding with other breeds was not detected.
Novel Active Disturbance Rejection Control Based on Nested Linear Extended State Observers
Authors: Abdul-Adheem Wameedh Riyadh , Azar Ahmad Taher , Ibraheem Ibraheem Kasim , Humaidi Amjad J.
Published: June 2020

In this paper, a Novel Active Disturbance Rejection Control (N-ADRC) strategy is proposed that replaces the Linear Extended State Observer (LESO) used in Conventional ADRC (C-ADRC) with a nested LESO. In the nested LESO, the inner-loop LESO actively estimates and eliminates the generalized disturbance. Increasing the bandwidth improves the estimation accuracy which may tolerate noise and conflict with H/W limitations and the sampling frequency of the system. Therefore, an alternative scenario is offered without increasing the bandwidth of the inner-loop LESO provided that the rate of change of the generalized disturbance estimation error is upper bounded. This was achieved by the placing of an outer-loop LESO in parallel with the inner one that estimates and eliminates the remaining generalized disturbance originating from the inner-loop LESO due to bandwidth limitations. The stability of LESO and nested LESO was investigated using Lyapunov stability analysis. Simulations on uncertain nonlinear single-input-single-output (SISO) system with time-varying exogenous disturbance revealed that the proposed nested LESO could successfully deal with a generalized disturbance in both noisy and noise-free environments, where the Integral Time Absolute Error (ITAE) of the tracking error for the nested LESO was reduced by 69.87% from that of the LESO.
Feasibility Test and Analysis for Heavy Haul Freight Using WDPS Based on MIMO-OFDM
Authors: Lee Kangmi , Park Taewon
Published: June 2020

The technical feasibility of a heavy haul freight using WDPS (Wireless Distributed Power System) was verified for the first time in Korea. That consisted of a master locomotive, 50 freights and a slave locomotive. The master and slave locomotives were equipped with WDPS to distribute traction and braking control command data. MIMO-OFDM, which is strong in multi-path, was applied to the WDPS, and a repeater was installed on the 25th freight to secure coverage even with signal attenuation according to the terrain (curve, gradient) of the driving section. The test was carried out at an average speed of 100 km/h in the approximately 21 km from Jillye station to Busansinhang station in Korea. As a result of the test, it was confirmed that the traction function, braking function, pantograph control function, MCB function, and safety circuit function of the heavy haul freight using WDPS were perfectly controlled. Additionally, the air braking time was reduced by about 50% compared to the centralized control as the braking was controlled by two locomotives at the same time. For the first time, the operational feasibility of heavy haul freight using WDPS based on MIMO-OFDM in the 2.4 GHz/5 GHz band with a relatively short propagation distance was verified.