bluuebunny/crossref_metadata_2025 huggingface dataset:
Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy
Authors: Han Dong , Wang Wei , Jeon Julie Heejin , Shen Tao , Huang Xiangsheng , Yi Ping , Dong Bingning , Yang Feng
Published: August 2023

Phosphoinositide-dependent kinase-1 (PDK1) is a master kinase of the protein A, G, and C (AGC) family kinases that play important roles in regulating cancer cell proliferation, survival, and metabolism. Besides phosphorylating/activating AKT at the cell membrane in a PI3K-dependent manner, PDK1 also exhibits constitutive activity on many other AGC kinases for tumor-promoting activity. In the latter case, PDK1 protein levels dominate its activity. We previously reported that MAPK4, an atypical MAPK, can PI3K-independently promote AKT activation and tumor growth. Here, using triple-negative breast cancer (TNBC) cell models, we demonstrate that MAPK4 can also enhance PDK1 protein synthesis, thus phosphorylate/activate PDK1 substrates beyond AKT. This new MAPK4-PDK1 axis alone lacks vigorous tumor-promoting activity but cooperates with our previously reported MAPK4-AKT axis to promote tumor growth. Besides enhancing resistance to PI3K blockade, MAPK4 also promotes cancer cell resistance to the more stringent PI3K and PDK1 co-blockade, a recently proposed therapeutic strategy. Currently, there is no MAPK4 inhibitor to treat MAPK4-high cancers. Based on the concerted action of MAPK4-AKT and MAPK4-PDK1 axis in promoting cancer, we predict and confirm that co-targeting AKT and PDK1 effectively represses MAPK4-induced cancer cell growth, suggesting a potential therapeutic strategy to treat MAPK4-high cancers.
TrenchR: An R package for modular and accessible microclimate and biophysical ecology
Authors: Buckley Lauren B. , Briones Ortiz Bryan A. , Caruso Isaac , John Aji , Levy Ofir , Meyer Abigail V. , Riddell Eric A. , Sakairi Yutaro , Simonis Juniper L.
Published: August 2023

Much understanding of organismal responses to climate change and variability relies on the assumption that body temperatures are equal to temporally averaged air temperatures high above the ground. However, most organisms experience microclimates near the ground and acute exposure to solar and thermal radiation and thermal extremes can substantially elevate or depress their body temperatures. We introduce the TrenchR package, which aids in Translating Environmental Change into organismal responses. The package includes microclimate models to vertically scale weather station data to organismal heights. Additional functions model and temporally partition air and soil temperatures and solar radiation. TrenchR biophysical modeling tools include both general models for heat flows and specific models to predict body temperatures for a variety of ectothermic taxa. We also offer utility functions to aid in estimating the organismal and environmental parameters needed for biophysical ecology. TrenchR focuses on simple and modular functions so users can create transparent and flexible models for biophysical applications. The package aims to introduce and enable microclimate and biophysical modeling to improve ecological and evolutionary forecasting. We further this aim through a series of educational modules that introduce the field of biophysical ecology.
Spatial patterns and predictors of unintended pregnancy among reproductive age women in Ethiopia
Authors: Zeru Melkamu A. , Fenta Haile Mekonnen , Mitku Aweke A.
Published: August 2023

Introduction

Unintended pregnancy is amajor sexual and reproductive health problem that imposes substantial health, economical and psychosocial costs to individuals and society as well as significant emotional distress to women, families, and society. The main aim of this study was to investigate the spatial distribution and predictors of unintended pregnancy in Ethiopian regions and administrative zones.

Methods

This study was conducted based on data from 2016 Ethiopian Demographic and Health Survey. The prevalence of unintended pregnancy across regions and or zones was assessed using spatial analysis, and the effect of different factors on unintended pregnancy in Ethiopia was investigated using a generalized linear mixed model with a multistage clustered sampling strategy. The crude and best linear unbiased predictor estimations of zones were integrated with the shape file data to demonstrate the performance of each zone on maps.

Results

The prevalence of unintended pregnancy for reproductive women in Ethiopia was29.49%. The highest rates of unintended pregnancy were recorded in the North Gondar zone of the Amhara region and the Jima zone in the Oromiya region. The mixed effects model revealed that age [AOR = 0.78, 95% CI, 0.62–0.97], residence [AOR = 2.62, 95%CI, 1.94, 7.27], marital status [AOR = 0.05, 95%CI, 0.01–0.38], women education [AOR = 1.34, 95%CI, 0.75–2.39], smoking cigarettes [AOR = 3.67, 95CI, 1.17–11.56], and poorer wealth index [AOR = 1.89, 95% CI, 1.51–2.31] were significantly associated with unintended pregnancy.

Conclusion

In Ethiopia, unintended pregnancy is a public health issue, and prevention stratagem for unintended pregnancy among reproductive women need to be focused based on the identified predictors. The spatial distribution of unintended pregnancy varied greatly at zonal and regional levels in Ethiopia. Hence, we recommended that, creating awareness of sexual and reproductive health with special priority to the identified hotspot areas (Amhara, Oromiya and SNN regions) to reduce unintended pregnancy. Emphasis on fertility and contraceptive techniques should be given to couples by health professionals.
Covid-related surge in global wild bird feeding: Implications for biodiversity and human-nature interaction
Authors: Doremus Jacqueline , Li Liqing , Jones Darryl
Published: August 2023

The global extent of supplementary bird feeding is unknown but has consequences for bird conservation and human well-being. Using a measure of search intensity for words related to bird feeding from Google, we document a surge of interest in bird feeding that occurred around the world after Covid-19 led to lockdowns where people stayed home: 115 countries saw an increase in bird feeding search interest. We test whether the existence of interest in bird feeding is associated with greater species richness of bird species, our proxy for biodiversity, and find the relationship is highly significant. Covid-19 lockdowns may have persistent influences on global bird populations and humans’ connection to nature.
Outcome prediction in pediatric fever in neutropenia: Development of clinical decision rules and external validation of published rules based on data from the prospective multicenter SPOG 2015 FN definition study
Authors: Santschi Marina , Ammann Roland A. , Agyeman Philipp K. A. , Ansari Marc , Bodmer Nicole , Brack Eva , Koenig Christa
Published: August 2023

Background

Fever in neutropenia (FN) remains a serious complication of childhood cancer therapy. Clinical decision rules (CDRs) are recommended to help distinguish between children at high and low risk of severe infection. The aim of this analysis was to develop new CDRs for three different outcomes and to externally validate published CDRs.

Procedure

Children undergoing chemotherapy for cancer were observed in a prospective multicenter study. CDRs predicting low from high risk infection regarding three outcomes (bacteremia, serious medical complications (SMC), safety relevant events (SRE)) were developed from multivariable regression models. Their predictive performance was assessed by internal cross-validation. Published CDRs suitable for validation were identified by literature search. Parameters of predictive performance were compared to assess reproducibility.

Results

In 158 patients recruited between April 2016 and August 2018, 360 FN episodes were recorded, including 56 (16%) with bacteremia, 30 (8%) with SMC and 72 (20%) with SRE. The CDRs for bacteremia and SRE used four characteristics (type of malignancy, severely reduced general condition, leucocyte count <0.3 G/L, bone marrow involvement), the CDR for SMC two characteristics (severely reduced general condition and platelet count <50 G/L). Eleven published CDRs were analyzed. Six CDRs showed reproducibility, but only one in both sensitivity and specificity.

Conclusions

This analysis developed CDRs predicting bacteremia, SMC or SRE at presentation with FN. In addition, it identified six published CDRs that show some reproducibility. Validation of CDRs is fundamental to find the best balance between sensitivity and specificity, and will help to further improve management of FN.
Scientists’ deficit perception of the public impedes their behavioral intentions to correct misinformation
Authors: Choi Sera , Anderson Ashley A. , Cagle Shelby , Long Marilee , Kelp Nicole
Published: August 2023

This paper investigates the relationship between scientists’ communication experience and attitudes towards misinformation and their intention to correct misinformation. Specifically, the study focuses on two correction strategies: source-based correction and relational approaches. Source-based approaches combatting misinformation prioritize sharing accurate information from trustworthy sources to encourage audiences to trust reliable information over false information. On the other hand, relational approaches give priority to developing relationships or promoting dialogue as a means of addressing misinformation. In this study, we surveyed 416 scientists from U.S. land-grant universities using a self-report questionnaire. We find that scientists’ engagement in science communication activities is positively related to their intention to correct misinformation using both strategies. Moreover, the scientists’ attitude towards misinformation mediates the relationship between engagement in communication activities and intention to correct misinformation. The study also finds that the deficit model perception–that is, the assumption that scientists only need to transmit scientific knowledge to an ignorant public in order to increase understanding and support for science–moderates the indirect effect of engagement in science communication activities on behavioral intention to correct misinformation using relational strategies through attitude towards misinformation. Thus, the deficit model perception is a barrier to engaging in relational strategies to correct misinformation. We suggest that addressing the deficit model perception and providing science communication training that promotes inclusive worldviews and relational approaches would increase scientists’ behavioral intentions to address misinformation. The study concludes that scientists should recognize their dual positionality as scientists and members of their community and engage in respectful conversations with community members about science.
Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta)
Authors: Howarth Emmeline R. I. , Szott Isabelle D. , Witham Claire L. , Wilding Craig S. , Bethell Emily J.
Published: August 2023

Behaviour has a significant heritable component; however, unpicking the variants of interest in the neural circuits and molecular pathways that underpin these has proven difficult. Here, we present a comprehensive analysis of the relationship between known and new candidate genes from identified pathways and key behaviours for survival in 109 adult rhesus macaques (Macaca mulatta). Eight genes involved in emotion were analysed for variation at a total of nine loci. Genetic data were then correlated with cognitive and observational measures of behaviour associated with wellbeing and survival using MCMC-based Bayesian GLMM in R, to account for relatedness within the macaque population. For four loci the variants genotyped were length polymorphisms (SLC6A45-hydroxytryptamine transporter length-polymorphic repeat (5-HTTLPR),SLC6A4 STinpolymorphism,Tryptophan 5-hydroxylase 2(TPH2) andMonoamine oxidase A(MAOA)) whilst for the other five (5-hydroxytryptamine receptor 2A(HTR2A),Dopamine Receptor D4(DRD4),Oxytocin receptor(OXTR),Arginine vasopressin receptor 1A(AVPR1a),Opioid receptor mu(μ) 1(OPRM1)) SNPs were analysed.STingenotype,DRD4haplotype andOXTRhaplotype were significantly associated with the cognitive and observational measures of behaviour associated with wellbeing and survival. Genotype for5-HTTLPR,STinandAVPR1a, and haplotype forHTR2A,DRD4andOXTRwere significantly associated with the duration of behaviours including fear and anxiety. Understanding the biological underpinnings of individual variation in negative emotion (e.g., fear and anxiety), together with their impact on social behaviour (e.g., social attention including vigilance for threat) has application for managing primate populations in the wild and captivity, as well as potential translational application for understanding of the genetic basis of emotions in humans.
Analysis of gene duplication within the Arabidopsis NUCLEAR FACTOR Y, subunit B (NF-YB) protein family reveals domains under both purifying and diversifying selection
Authors: Siriwardana Chamindika L. , Risinger Jan R. , Carpenter Emily Mills , Holt Ben F.
Published: August 2023

Gene duplication is an evolutionary mechanism that provides new genetic material. Since gene duplication is a major driver for molecular evolution, examining the fate of duplicated genes is an area of active research. The fate of duplicated genes can include loss, subfunctionalization, and neofunctionalization. In this manuscript, we chose to experimentally study the fate of duplicated genes using the Arabidopsis NUCLEAR FACTOR Y (NF-Y) transcription factor family. NF-Y transcription factors are heterotrimeric complexes, composed of NF-YA, NF-YB, and NF-YC. NF-YA subunits are responsible for nucleotide-specific binding to a CCAAT cis-regulatory element. NF-YB and NF-YC subunits make less specific, but essential complex-stabilizing contacts with the DNA flanking the core CCAAT pentamer. While ubiquitous in eukaryotes, each NF-Y family has expanded by duplication in the plant lineage. For example, the model plant Arabidopsis contains 10 each of the NF-Y subunits. Here we examine the fate of duplicated NF-YB proteins in Arabidopsis, which are composed of central histone fold domains (HFD) and less conserved flanking regions (N- and C-termini). Specifically, the principal question we wished to address in this manuscript was to what extent can the 10 Arabidopsis NF-YB paralogs functionally substitute the genes NF-YB2 and NF-YB3 in the promotion of photoperiodic flowering? Our results demonstrate that the conserved histone fold domains (HFD) may be under pressure for purifying (negative) selection, while the non-conserved N- and C-termini may be under pressure for diversifying (positive) selection, which explained each paralog’s ability to substitute. In conclusion, our data demonstrate that the N- and C-termini may have allowed the duplicated genes to undergo functional diversification, allowing the retention of the duplicated genes.
Exploring Endotypes in Chronic Rhinosinusitis (ExpRess): Protocol for a cohort study
Authors: Gokani Shyam Ajay , Jefferson Matthew , Gavrilovic Jelena , Clark Allan , Hildebrand Falk , Wileman Tom , Hopkins Claire , Philpott Carl
Published: August 2023

Background

Chronic Rhinosinusitis (CRS) affects approximately 1 in 10 UK adults and impacts quality of life quality of life significantly. Response to treatment may be driven by individual CRS endotypes and therefore work to delineate biomarker clusters that may separate responders from non-responders is needed. The ongoing MACRO three-arm parallel-group trial randomises adult CRS patients to endoscopic sinus surgery, macrolide therapy or placebo.

Aim

This study aims to correlate CRS endotypes with clinical parameters from the ongoing MACRO trial, including olfactory function and outcomes in terms of response to treatment using core biomarkers sets.

Methods

Adult CRS patients enrolled into the MACRO trial will be recruited from participating UK otorhinolaryngology departments. Nasal tissue samples and swabs will be obtained in theatre or clinic from patients randomised to all three trial arms. Nasal tissue will be analysed with multiplex electrochemiluminescence for 32 cytokines including IL-5, IL-13, IgE and periostin. Bacterial swabs will be analysed using illumina miSeq 16S amplicon sequencing. Mean expression for each biomarker will be reported for treatment responder and non-responder groups. Correlation of biomarkers with MACRO trial outcome data such as endoscopic evaluation scores and quality-of-life improvement scores will be reported.

Discussion

Defining clear endotypes in CRS will contribute to refining patient pathways for the efficient use of clinical resources. This work may lay the groundwork for future studies to predict which patients might respond to medical or surgical therapy.
How stra(i)nge are your controls? A comparative analysis of metabolic phenotypes in commonly used C57BL/6 substrains
Authors: Sil Annesha , Souza Matos Marina , Delibegovic Mirela , Platt Bettina
Published: August 2023

In recent years, insufficiently characterised controls have been a contributing factor to irreproducibility in biomedical research including neuroscience and metabolism. There is now a growing awareness of phenotypic differences between the C57BL/6 substrains which are commonly used as control animals. We here investigated baseline metabolic characteristics such as glucose regulation, fasted serum insulin levels and hepatic insulin signalling in five different C57BL/6 substrains (N, J, JOla, JRcc) of both sexes, obtained from two commercial vendors, Charles River Laboratories (Crl) and Envigo (Env). Our results indicate systematic and tissue-specific differences between substrains, affected by both vendor and sex, in all parameters investigated, and not necessarily mediated by the presence of the NntC57BL/6J mutation. Not only were there differences between 6J and 6N as expected, all three 6J substrains exhibited different profiles, even from the same breeder. Two distinct metabolic profiles were identified, one in which low insulin levels resulted in impaired glucose clearance (6JCrl; both sexes) and the other, where sustained elevations in fasted basal insulin levels led to glucose intolerance (male 6JRccEnv). Further, 6JRccEnv displayed sex differences in both glucose clearance and hepatic insulin signalling markers. In comparison, the two 6N substrains of either sex, irrespective of vendor, did not exhibit considerable differences, with 6NCrl animals presenting a good choice as a healthy baseline ‘control’ for many types of experiments. Overall, our data emphasise the importance of selecting and characterising control subjects regarding background, sex, and supplier to ensure proper experimental outcomes in biomedical research.
Quantile regression for static panel data models with time-invariant regressors
Authors: Tao Li , Tai Lingnan , Tian Maozai
Published: August 2023

This paper proposes two new weighted quantile regression estimators for static panel data model with time-invariant regressors. The two new estimators can improve the estimation of the coefficients with time-invariant regressors, which are computationally convenient and simple to implement. Also, the paper shows consistency and asymptotic normality of the two proposed estimator for sequential and simultaneous N, T asymptotics. Monte Carlo simulation in various parameters sets proves the validity of the proposed approach. It has an empirical application to study the effects of the influence factors of China’s exports using the trade gravity model.
Queer coming of age: Recognizing the genre’s classic cluster
Authors: Windhauser Brad
Published: August 2023

The queer coming-of-age film genre, although gaining more visibility with a recent slate of films, has not always been recognized or studied as a genre. Providing a unique sense of the struggles queer people experience coming of age in our society, these films serve an important function. By documenting the struggles cis-het society creates for queer adolescents as well as providing hope for the queer audience looking for guidance through this often-difficult period, these films also reveal how queer adolescents lack the same resources and support as their cis-het peers. Since the films in this genre are often considered ‘coming out’, ‘drama’ or ‘comedies’, recognizing this genre’s classic cluster will better focus attention on the genre’s semantic elements as well as the cause-and-effect syntax in which they are placed. This genre lens reveals the impact of the struggles queer adolescents experience coming of age in our society.
Lesbian and Femme Care at the 2023 Sundance Film Festival, Park City, UT, 19-29 January 2023
Authors: Kumar Rebecca
Published: August 2023

Review of: Lesbian and Femme Care at the 2023 Sundance Film Festival, Park City, UT, 19–29 January 2023
Searching for belonging: learning from students’ photographs about their higher education experiences
Authors: Huang Zhuo Min , Cockayne Heather
Published: August 2023

Searching for belonging is the transformative individual process of developing connections, making homes and hoping in the ecologies of a community. Belongingness influences academic performance, confidence and well-being. Therefore, understanding how students embody and search for belongingness in their higher education experience provides insights into student agency during their learning and development. Through an arts-based method – photography – we facilitated postgraduate students’ reflections on their higher education experience at a UK university during the Covid-19 pandemic. This method decentres the dominant role of (usually English) language in producing knowledge about student experience. Our findings suggest that belonging is constructed through a liminal space of making embodied, material, affective, aesthetic and mental connections to a new environment and is grounded in the humanistic endeavour of being a connected person at a place. The students’ photographic insights about belonging are not confined by essentialist boundaries of their nationalities or student status, which might be foregrounded in the existing narratives about (‘international’) students and their experience in UK higher education. Instead, they reflect a humanistic, holistic sense making of students’ experience, in which the students are evident as agentive, confident, and capable of home-making and searching for belonging.
Negros em Programas de Pós-Graduação em Filosofia no Brasil
Authors: Sá Moreira Fernando
Published: August 2023

Resumo: O presente artigo analisa a composição étnico-racial dos programas de pós-graduação brasileiros da área de filosofia. O propósito é identificar as características gerais da área e analisar os dados disponíveis sobre as declarações de cor/raça em seus mestrados e doutorados. Espera-se que essas análises sejam úteis para a discussão e proposição de ações afirmativas em tais programas. O resultado obtido evidenciou que negros estão largamente sub-representados na pós-graduação em filosofia. Com efeito, a área é atualmente entre as humanidades a de maior concentração de estudantes declarados brancos. Isto posto, o estudo especula possíveis causas e consequências dessa situação, procurando encontrar caminhos para o enfrentamento efetivo do racismo acadêmico.
Palavras-chave: Desigualdades Raciais; Perfil Discente; Racismo Acadêmico.
Black People in Philosophy Graduate Programs in Brazil
Abstract: The present paper analyzes the ethnic-racial composition of Brazilian graduate programs in the field of philosophy. Its purpose is to identify the general characteristics of the field, and to analyze the available data on color/race in its master’s and doctoral programs. It is hoped that these analyzes will be useful for the discussion and proposition of affirmative actions in such programs. The result obtained showed that blacks are largely underrepresented in Brazilian philosophy graduate schools. Indeed, the field is currently the one with the highest concentration of students declared to be white among all the human sciences in Brazil. With that being said, the study speculates on possible causes and consequences of that situation, seeking to find ways to effectively confront academic racism.
Keywords: Racial Inequalities; Student Profile; Academic Racism.
Schwarze Menschen an Graduiertenprogrammen für Philosophie in Brasilien
Zusammenfassung: Der vorliegende Beitrag analysiert die ethnisch-rassische Zusammensetzung brasilianischer Graduiertenprogramme im Bereich Philosophie. Sein Zweck ist es, die allgemeinen Merkmale des Fachgebiets zu identifizieren und die verfügbaren Daten zu Farbe/Rasse in seinen Master- und Doktoratsprogrammen zu analysieren. Es ist zu hoffen, dass diese Analysen für die Diskussion und den Vorschlag von Maßnahmen positiver Diskriminierung in solchen Programmen nützlich sein werden. Das hier erreichte Ergebnis zeigte, dass Schwarze in den brasilianischen Graduiertenkollegs stark unterrepräsentiert sind. In der Tat ist das Fachgebiet derzeit dasjenige unter allen Humanwissenschaften in Brasilien mit der höchsten Konzentration von Studenten, die als weiß deklariert werden. Vor diesem Hintergrund spekuliert diese Studie über mögliche Ursachen und Folgen dieser Situation und versucht, Wege zu finden, um akademischem Rassismus wirksam entgegenzutreten.
Schlüsselwörter: Rassenungleichheiten; Studierendenprofil; Akademischer Rassismus.
 
Data de registro: 16/06/2022
Data de aceite: 26/10/2022
Universidad e interculturalidad: una cuestión pendiente
Authors: Gentile María Beatriz
Published: August 2023

La relación Universidad e Interculturalidad es una problemática que continúa ausente no sólo en el diseño de las políticas universitarias, sino también en los debates del campo científico y cultural. No alcanza con reconocer la diversidad en el marco de un liberalismo democrático y multicultural; ni tampoco se trata de esencializar identidades étnicas. El desafío es pensar la interculturalidad no como un destino sino como una herramienta de trabajo que permita ir transformando las estructuras epistémicas, pero a su vez las estructuras políticas y sociales, base sobre las que se asientan las desigualdades. En este sentido, la Universidad resulta clave ya que es aquí donde se forman docentes para todos los ciclos del sistema educativo y profesionales que ocupan posiciones de poder en los ámbitos políticos, económicos y sociales.
Metapoética erotizada en Lazy Thoughts of a Lazy Woman, de Grace Nichols
Authors: Galettini Azucena
Published: August 2023

Grace Nichols, poeta guyanesa que reside en el Reino Unido desde 1977, ha recibido especial reconocimiento por sus tres primeras obras: I is a Long-Memoried Woman (1983, ganadora del Commonwealth Poetry Prize), The Fat Black Woman’s Poems (1984) y Lazy Thoughts of a Lazy Woman (1989), en las que la crítica traza una cierta continuidad. Uno de los ejes de análisis centrales ha sido la utilización presente en su obra del erotismo. Así, desde una perspectiva feminista, se la ha alabado y cuestionado por la preponderancia del cuerpo y de la sexualidad en la construcción de sus personas poéticas (Escudero, 2000; Harding, 2007; Scalon, 1998). La presencia de la sexualidad de la mujer y el rol fundamental que Nichols le asigna al cuerpo ha sido leída en clave de «escritura femenina», tomando como marco las teorías de Hélène Cixous, Luce Irigaray, Julia Kristeva (Griffin, 1993; Webhofer, 1996; DeCaires Narain, 2004).
El propósito del presente trabajo es dar cuenta de otra perspectiva posible para pensar la presencia del erotismo en la obra de Nichols: como una forma de construir una metapoética en la que sensualidad y creación se funden. El erotismo no sería, entonces un arma que Nichols esgrime en tanto «poelítica» feminista (Chancy, 1997; Bringas López, 2003), sino más bien una declaración sobre cómo comprender el acto creador.
Para ello, a partir de la visión de erotismo definida por Georges Bataille (1985, [1957]), el enlace entre lo erótico y lo poético que establece Octavio Paz (1994) y el uso de la sexualidad como fuente creadora que defiende Audre Lorde (1984), analizaremos  tres poemas de Lazy Thoughts of a Lazy Woman: «On Poems and Crotches, «My Black Triangle» y «With Apologies to Hamlet».
Memoria aural de una lucha
Authors: Lvovich Lea
Published: August 2023

La inundación de Santa Fe en 2003 fue una de las mayores tragedias evitables de la historia argentina. En este artículo se intenta auscultar los sonidos de la lucha de una de las organizaciones nacidas para exigir justicia. Durante más de 10 años, la Marcha de las Antorchas se manifestó todos los martes (el día que entró el agua a la ciudad) y los 29 de cada mes. Esta agrupación se destaca por trascender el reclamo de reparación material: pretende verdad y castigo a los culpables. 

Se abordan las formas del reclamo desde la perspectiva de los sound studies, lo que permite percibir al escenario de la protesta como territorio acústico y atender a lo que los sonidos tienen para informar. A pesar de que la Marcha de las Antorchas ha buscado impacto visual, lo audible se impone a lo visible por su particular modo de afectar. Se analizan los rituales representativos de la agrupación, como el nombrar en voz alta a las víctimas y gritar en la puerta del edificio de Tribunales, como también el rol de las canciones, especialmente No nos moverán y la contrafacta Inundador.
Identification of Schizosaccharomyces pombe ird Mutants Resistant to Glucose Suppression and Oxidative Stress
Authors: Yilmazer M. , Bayrak B. , Kartal B. , Uzuner S. K. , Palabiyik Bedia
Published: July 2023

Glucose is both the favourite carbon and energy source and acts as a hormone that plays a regulating role in many biological processes. Calorie restriction extends the lifespan in many organisms, including Schizosaccharomyces pombe, while uptake of high glucose leads to undesired results, such as diabetes and aging. In this study, sequence analysis of Schizosaccharomyces pombe ird5 and ird11 mutants was performed using next-generation sequencing techniques and a total of 20 different mutations were detected. ird11 is resistant to oxidative stress without calorie restriction, whereas ird5 displays an adaptive response against oxidative stress. We selected nine candidate mutations located in the non-coding (6) and coding (3) region among a total of 20 different mutations. The nine candidate mutations, which are thought to be responsible for ird5 and ird11 mutant phenotypes, were investigated via forward and backward mutations by using various cloning techniques. The results of this study provide report-like information that will contribute to understanding the relationship between glucose sensing/signalling and oxidative stress response components.
(Pre)analytical considerations concerning the analysis of synovial calprotectin
Authors: Alkadhem Mohammed F. , Wagenmakers-Huizenga Lucie M.F. , Wouthuyzen-Bakker Marjan , Muller Kobold Anneke C.
Published: August 2023

Objectives

Several studies have demonstrated that synovial calprotectin is a highly accurate biomarker in diagnosing periprosthetic joint infections (PJI). Assuring reliability is of great importance and coincides with adequate preanalytical handling. This study focuses on potentially interfering factors.

Methods

To assess the stability of synovial calprotectin, the effect of time, storage temperature, EDTA, freeze-thaw cycles, viscosity, and blood and lipid contamination was investigated. In the blood and lipid contamination experiments, hemolyzed and non-hemolyzed blood, homogenized adipose tissue, intralipid and chylomicrons were added. The effect of viscosity was investigated using freeze-thaw cycles, enzymatic pretreatment and sonification.

Results

No effect on synovial calprotectin levels was observed in synovial samples kept at room temperature compared to samples kept at 4 °C for up to seven days of storage. Freeze-thaw cycles did not result in significantly different calprotectin levels, although samples without EDTA resulted in higher recoveries after 1 and 2 freeze-thaw cycles. Blood and lipid contamination did not interfere with accurate synovial calprotectin analysis. Sample pretreatment to reduce sample viscosity by pretreating samples with DNAse and/or hyaluronidase did not influence calprotectin analysis. Sonification, however, resulted in increased calprotectin values.

Conclusions

Synovial calprotectin is a stable biomarker and its analysis is not easily influenced by potential interfering factors.
An analysis of factors affecting survival in prenatally diagnosed omphalocele
Authors: Ayhan Işıl , Demirci Oya , Uygur Lütfiye , Odacilar Şahap , Özbay Ayvaz Olga Devrim , Karaman Ali , Celayir Ayşenur
Published: August 2023

Objectives

To estimate factors affecting survival in prenatally diagnosed omphalocele, factors predicting genetic abnormalities, and association of omphalocele and specific groups of anomalies.

Methods

A retrospective observational study was performed, analyzing data of all omphalocele cases diagnosed prenatally in the perinatology clinic of a referral center. Demographic data, characteristics of the omphalocele (size, content, associated anomalies), results of genetic testing, pregnancy outcomes and postnatal outcomes were analyzed.

Results

Sixty-nine fetuses with omphalocele were included. The prevalence of omphalocele in livebirth was 0.007 %. Overall survival during the study period was 73.9 %. Twenty-eight (71.7 %) out of 39 cases with associated anomalies who were born live, survived, whereas survival was 85.7 % in the isolated cases. The most common anomaly associated with omphalocele were cardiac defects with 42 %; followed by placental or umbilical cord anomalies (28.9 %), skeletal defects (27.5), genitourinary anomalies (20.2 %), central nervous system (18.8 %) and facial anomalies (7.2 %), respectively. Eighty-five percent of the fetuses had at least one additional anomaly or ultrasound finding. Skeletal abnormalities and staged surgical repair of omphalocele were associated with survival. Associated skeletal anomalies and staged repair significantly increase the risk of postnatal death (OR: 4.6 95 % CI (1.1–19.5) and (OR: 10.3 95 % CI (1.6–63.9), respectively).

Conclusions

Associated skeletal abnormalities and staged surgical repair are negatively associated with postnatal survival.
Small mammals of a northern salt-affected grassland
Authors: LaFond Lynda R. , Darby Brian J. , Boulanger Jason R. , Yurkonis Kathryn A.
Published: August 2023

While many studies have characterized small mammals of the southern and central Great Plains (USA), far fewer have documented small mammals of the northern Great Plains which differ dramatically in plant structure and composition. We examined the presence and distribution of small mammals captured at a salinity-affected grassland in northeastern North Dakota (2018–2021). We captured 12 species from 8 genera including Microtus pennsylvanicus (n = 724), Peromyscus (maniculatus) sonoriensis (n = 114), Sorex cinereus (n = 54), and Zapus hudsonius (n = 43). We evaluated the extent to which these species varied with plant and environmental characteristics. M. pennsylvanicus was positively associated with plant cover and soil moisture and P. (maniculatus) sonoriensis was positively associated with forb cover and negatively associated with litter and elevation. Z. hudsonius was negatively associated with forb cover and soil moisture and S. cinereus was positively associated with cover and negatively associated with salinity. These species associated with their environments differently than their more southern counterparts and reinforce the notion that not all areas, even in relatively intact grasslands, are available to all species. Future studies are needed to further examine more infrequently captured species, including a Sorex hoyi, an Onychomys leucogaster, and eight Myodes gapperi in this region.
Phonetic phenomena in New Flamenco. The linguistic stylisation of flamenco over time: a corpus study
Authors: Fernández de Molina Ortés Elena
Published: August 2023

The aim of this article is to check whether the phenomena that were indexicalised in flamenco singing during the early stages of the professionalisation of singing (seseo, fricatisation, aspiration and elision of sounds, rhotacism) have been preserved over the generations. Above all, we want to know whether these phenomena have survived in this period and in the new varieties of the genre, such as flamenco fusion. For this work we elaborated and transcribed two flamenco corpora from the analysis of 44 h of recordings and a total of 94,978 lemmas with phonetic phenomena. The results have shown that, indeed, in flamenco there are indexical phonetic phenomena that have been registered as representative marks of the cante. In fact, the cantaores themselves, regardless of their origin, use the same sounds. However, a decrease in the use of phonetic phenomena of the genre in New Flamenco has been observed, especially in the younger generations.
Production cross-section calculations of some strontium isotopes via (p,x) reactions on natural abundance rubidium using different level density models
Authors: Şekerci Mert , Özdoğan Hasan , Kaplan Abdullah
Published: August 2023

The cross-section, a measure of the probability that a nuclear reaction will occur, needs to be calculated properly. The level density model used in the computations is one of several factors which may affect the theoretical value of the cross-section in a nuclear reaction. In this study, it is aimed to investigate the influence of level density models on the cross-section calculations in the production of some strontium isotopes from the natural abundance of rubidium by proton induced reactions. To this end, calculations have been made by triggering the six level density models that can be used in the TALYS code, one after the other. To allow a visual comparison of the effects of the level density models, the obtained calculation outputs and the experimental results from the literature have been plotted together. Furthermore, numerical comparisons have been made with the calculated values of a deviation factor.
Soil Structure in Volcanic Pumice Soil of Dozou-sawa River Evaluated from In Situ and Laboratory Tests
Authors: Hashimoto Hiroyuki , Horinouchi Koki , Sato Itsuki , Kuno Makoto , Kuwano Reiko
Published: August 2023

Volcanic pumice soils are widely distributed in many countries and sometimes cause severe geo-disasters including large-scale slope failures and long-distance debris flows triggered by seismic ground motion. However, the understanding of the mechanical properties of volcanic pumice soils is still limited because volcanic pumice soils generally have a sensitive structure and are typically distributed in mountain areas that are sometimes difficult to approach. In this study, a portable in situ direct shear test apparatus was developed to evaluate shear strengths of a volcanic pumice soil without disturbing the natural soil structure. A series of in situ direct shear tests was conducted for the volcanic pumice soil in Dozou-sawa river, where a large-scale slope failure followed by debris flow occurred in the 2008 Iwate-Miyagi Nairiku Earthquake. A series of laboratory direct shear tests and triaxial tests were also carried out with intact and reconstituted specimens. The in situ direct shear tests and laboratory direct shear tests using intact specimens showed consistent shear strength. Intact specimens had an extremely loose and sensitive structure because of highly crushable porous particles and a very loose soil skeleton sustained by weak cementation between particles. Such a fragile soil structure could never be reproduced in reconstituted specimens. It was confirmed that the soil structure significantly affected peak shear strengths. For the evaluation of mechanical behavior of such sensitive soils, it is important to use as few disturbed specimens as possible. The newly developed in situ direct shear test apparatus was confirmed to be an effective tool to simply evaluate the shear strength of sensitive volcanic pumice soils on site under low disturbed conditions.
VIII Memorias encuentro de investigación Alberto Magno
Authors: Núñez Canaria Fredy Esteban
Published: August 2023

Recopilación ponencias de las memoria VIII Encuentro de investigación Alberto magno.
Change of Cr, Co, and V concentrations in forest trees by species, organ, and soil depth
Authors: Erdem Ramazan
Published: July 2023

Heavy metal pollution is one of the most important environmental problems threatening living organisms and environmental health. Thus, there is much research interest in monitoring and reducing heavy metal pollution. Plants’ potential to accumulate heavy metals in various organs differs greatly. Therefore, it is necessary to determine the most suitable species and organs first and acquire knowledge of the subjects such as the transfer of heavy metals within plants and their particular intake into plants. This study investigated Cr, Co, and V, which are among the most important and dangerous heavy metals, and are listed in the primary pollutant list of the Agency for Toxic Substances and Disease Registry. Their concentrations were studied at different depths of soils where Pinus nigra, Pinus sylvestris, Fagus orientalis, and Abies nordmanniana subsp. bornmüelleriana species are grown, in the leaves, cones, wood, bark, and roots. The results showed that the intake of these elements into plant bodies generally occurs through the soil. Additionally, the highest concentrations in both leaves and roots were generally obtained in Fagus orientalis and Abies nordmanniana subsp. bornmüelleriana species. It can be stated that those species are the most suitable species to monitor and reduce heavy metal pollution.
Effect of chemical crosslinking on the biodegradation rate of kraft paper
Authors: Korpela Antti , Tanaka Atsushi , Asikainen Jaakko
Published: July 2023

Wood-based paper fibers are inherently biodegradable. In contact with moist soil and in compost, papermaking fibers are readily broken down by soil microbes. Resistance to biodegradation is needed, as paper is used for special applications such as mulching in agriculture and forestry, the coating of construction materials, and for packing and wrapping under conditions where packaging materials may be exposed to contact with moist soil or other type microbial active contamination. A preceding study showed that paper chemical crosslinking with glyoxal, citric acid (CA), or methylated 1,3-dimethylol-4,5-dihydroxyethylene urea (mDMDHEU) results in substantially improved paper wet strength and lower paper water absorbency. The present study examined the efficiency of chemical crosslinking treatments with CA and with mDMDHEU to decrease the biodegradation rate of laboratory paper sheets and a sack paper, both made of kraft fibers. The biodegradation was examined using a 48-h enzymatic degradation test and a 2-month soil burial test. The results indicate that chemical crosslinking is an effective non-biocidal method for making sulphate kraft paper more resistant to biodegradation. In some end-uses, improved resistance to biodegradation, along with improved paper wet performance, can enhance paper performance comparable to plastic films.
THE IMPLEMENTATION OF WORDWALL GAMES IN VOCABULARY LEARNING
Authors: Ilahiyati Nasru , Rohmah Zuliati , Hamamah Hamamah
Published: August 2023

ABSTRACTThis article investigates the use of online-based application "WordWall Games" as a vocabulary learning tool. The research aims to observe the participants' ability to enhance pronunciation, memorize vocabulary, and construct words into sentences. This study addresses three research questions: How is the design of WordWall games beneficial for developing students' vocabulary?; How is the application of WordWall games integrated into vocabulary teaching?; How do students acquire new vocabulary after being instructed using WordWall? To collect the data for this study, the researchers conducted direct observations involving ten students studying English Literature in Malang as participants of this study. Six game-based media were utilized, including Random Card Games, Crossword Games, True or False Tasks, Translation Tasks, Construct Word Tasks, and Anagram Tasks. The  research findings indicate that using WordWall games as a learning tool effectively improves students’ pronunciation, memorization, and sentence construction skills.ABSTRAKArtikel ini membahas penggunaan aplikasi berbasis online "WordWall games" sebagai alat pembelajaran kosakata. Penelitian ini bertujuan untuk mengobservasi kemampuan partisipan dalam meningkatkan pengucapan, menghafal, dan menyusun kata-kata menjadi kalimat. Artikel ini membahas tiga pertanyaan: 1. Bagaimana desain WordWall games bermanfaat untuk mengembangkan kosakata siswa? 2. Bagaimana penerapan WordWall games dalam pengajaran kosakata? 3. Bagaimana siswa memperoleh kosakata baru setelah diajarkan menggunakan WordWall? Peneliti melakukan observasi langsung yang melibatkan sepuluh mahasiswa yang sedang menempuh pendidikan Sastra Inggris di Malang. Enam media berbasis permainan digunakan, termasuk Random Card Games, Crossword Games, True or False Tasks, Translation Tasks, Construct Word Tasks, dan Anagram Tasks. Temuan penelitian menunjukkan bahwa penggunaan WordWall games sebagai alat pembelajaran efektif dalam meningkatkan pengucapan, penghafalan, dan kemampuan menyusun kalimat.How to Cite: Ilahiyati, N., Rohmah, Z., Hamamah. (2023). The Implementation of Wordwall Games in Vocabulary Learning. IJEE (Indonesian Journal of English Education), 10(1), 144-159. doi:10.15408/ijee.v10i1.29905.