bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case of Rapidly Progressive Unilateral Non-Nephrogenic Hemorrhagic Bullous Calciphylaxis Responding to Systemic Sodium Thiosulfate Therapy
Authors: Wetstone Rachel , Yim Rebecca , Gabel Colleen , Yim Kaitlyn , O’Donnell Patrick , Nutan Fnu
Published: November 2024

Background. Calciphylaxis is a rare and life-threatening condition characterized by cutaneous necrosis resulting from vessel calcification and thrombosis. Commonly associated with end-stage renal disease and hyperparathyroidism, calciphylaxis presents as retiform purpura evolving into necrotic eschars. Case Report. This report details an atypical case of non-nephrogenic unilateral bullous calciphylaxis in a 71-year-old female, emphasizing the importance of considering calciphylaxis in the differential diagnosis of bullous disorders. The patient’s presentation included hemorrhagic bullae on the left leg, prompting a challenging differential diagnosis. Diagnosis was confirmed by skin biopsy, highlighting the role of confirmatory biopsy in atypical cases such as this, with a broad differential diagnosis. Treatment involved intravenous sodium thiosulfate infusions and wound care, resulting in significant improvement after 6 months. Conclusion. This case underscores the diagnostic complexity of bullous calciphylaxis, and clinicians are urged to consider this condition in patients with painful bullae and retiform purpura. Early recognition is crucial for initiating prompt intervention and improving outcomes in patients with this high-mortality disease.
Use of Negative Pressure Wound Therapy in the Management of Extreme Crush Abdominopelvic Injuries: An In-Depth Case Study and Literature Review
Authors: De Luca Giuseppe , Tedeschi Pasquale , Maruccia Michele , Malerba Silvia , Puglisi Giuliana , Prete Francesco , Vittore Francesco , Giudice Giuseppe , Testini Mario
Published: November 2024

Background. Negative pressure wound therapy (NPWT) has significantly transformed wound care, particularly the management of complex injuries and unresponsive wounds. Crush injuries from road traffic accidents pose intricate challenges due to their severity, often requiring multimodal interventions. NPWT accelerates healing by stimulating tissue formation and reducing inflammation; however, its use necessitates careful patient selection and wound assessment for potential complications. Case Report. A 16-year-old male sustained catastrophic crush injuries involving extensive soft tissue damage, bone exposure, bowel perforation, and genitourinary trauma in a vehicular accident involving a farm vehicle run-over event. The patient received various interventions, including NPWT combined with tension sutures for wound management. The case highlights the multidisciplinary approach required to manage primary wounds and complications. NPWT facilitated granulation tissue formation, aiding wound closure without necessitating alternative methods such as skin grafting or flap coverage. Conclusion. This case underscores NPWT's effectiveness in the management of severe crush injuries. While successful wound closure was achieved, as of this writing postoperative-recovery challenges persist, emphasizing the importance of multidisciplinary care in long-term recovery. The case reaffirms NPWT as a valuable option in managing extensive injuries resulting from road traffic accidents.
Diabetic retinopathy and termination of pregnancy. For discussion
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch, Khabarovsk, Russian Federation, Pomytkina N.V. ,   Far-Eastern State Medical University, Khabarovsk, Russian Federation, Sorokin E.L. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch, Khabarovsk, Russian Federation,   Far-Eastern State Medical University, Khabarovsk, Russian Federation, Pashentsev I.E. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch, Khabarovsk, Russian Federation
Published: November 2024

Purpose. Assessment of the influence of the clinical course of diabetic retinopathy (DR) in pregnant women with diabetes mellitus (DM) on obstetric tactics of pregnancy management and the formation of indications for its premature termination.

Material and methods. 49 pregnant women with type 1 of DM and progression of DR: 34 with proliferative diabetic retinopathy (PDR) and 15 with preproliferative diabetic retinopathy (PPDR). Macular edema was detected in 5 patients. Standard ophthalmological examination, optical coherence tomography (OCT) and OCT angiography were performed in all trimesters of pregnancy and 3 months after birth. The pregnancy outcomes of the patients were analyzed according to medical records. All patients underwent retinal laser coagulation (RLC) during gestation.

Results. Performing RLC during pregnancy stabilized the course of DR before delivery in 78% of patients (38 women, 76 eyes). The progression of DR continued in the postpartum period in 11 patients (22 eyes), and they underwent additional RLC or the introduction of anti-VEGF drugs. Delivery occurred by cesarean section at 36–37 weeks of pregnancy due to the development of preeclampsia, progression of diabetic nephropathy or fetal hypoxia in the majority of pregnant women (82%, 40 patients). 9 pregnant women (18%) gave birth naturally at 38–39 weeks of gestation. Despite the progressive course of DR, there was no case when it became necessary to terminate pregnancy for ophthalmological reasons. Our patients also had no ophthalmological indications for the management of labor with the exception of the pushing period. In our opinion, with active management of a pregnant woman with DR and timely treatment measures, the main indications for cesarean section should be only somatic and obstetric-gynecological.

Conclusion. Panretinal laser coagulation, performed during gestation with the progression of DR, can stabilize the course of retinopathy in the majority of pregnant women with DM. Active management of pregnant women with DM and timely RLC make it possible to exclude the PDR progression from the indications for premature abortion. Carrying out RLC in the progression of DR during gestation allows to minimize ophthalmological indications for cesarean section in pregnant women with DM.

Key words: diabetic retinopathy, pregnancy, termination of pregnancy, cesarean section, retinal laser coagulation
Impaired mobility of the eyeball in patients with traumatic strabismus
Authors:   S. Fyodorov Eye Microsurger y Federal State Institution, Tambov branch, Tambov, Russian Federation, Matrosova Y.V. ,   G.R. Derzhavin Tambov State University, Tambov, Russian Federation, Kataev M.G. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Fabrikantov O.L. ,   S. Fyodorov Eye Microsurger y Federal State Institution, Tambov branch, Tambov, Russian Federation,   G.R. Derzhavin Tambov State University, Tambov, Russian Federation, Shutova S.V. ,   S. Fyodorov Eye Microsurger y Federal State Institution, Tambov branch, Tambov, Russian Federation,   G.R. Derzhavin Tambov State University, Tambov, Russian Federation
Published: November 2024

Relevance. Limitation of eyeball mobility is one of the main signs of traumatic strabismus. The following main factors of its occurrence have been identified: trauma to the eye and periorbital region, orbital fracture, concussion and severe cranio-orbital or traumatic brain injury. Oculomotor function may suffer due to paresis/paralysis of the extraocular muscle, its mechanical damage or entrapment in the area of the fracture of the orbital bones (in cases where strabismus has developed as a result of an orbital fracture), or due to the formation of severe tissue fibrosis and restriction.

Purpose. To study the dynamics of oculomotor function before and after surgical treatment of traumatic strabismus in patients with dystopia of the eyeball and without it.

Material and methods. A retrospective analysis of outpatient records of 269 patients with traumatic strabismus was carried out.

Results. Dystopia of the eyeball was detected in 34%. Exophthalmos accounts for approximately a third of all dystopias occurring in traumatic strabismus. An isolated fracture of the orbital wall did not cause exophthalmos. In such cases, other types of dystopias were noted. But in more extensive and severe injuries to the skull, exophthalmos occurred in 10% of cases. Among all cases of exophthalmos, in 40% it developed as a result of injury to the eye or periorbital region, in 60% – with severe cranio-orbital damages (COD) and head injury. It was found that as a result of surgical treatment, the number of patients with normal eyeball mobility increased from 16 to 24%. Lack of eyeball mobility was noted in 7% of patients, while before treatment their number was almost 19%. In the group without dystopia with moderate oculomotor disorders, after treatment, the mobility of the eyeball did not improve in 65% of patients; it improved in 31% of patients; in the group with dystopia, 41% retained the same degree of mobility limitation, and improvement (decrease in the degree of limitation) was detected in 55% of patients.

Conclusion.It has been established that dystopia causes more severe oculomotor disorders. However, adequate surgical treatment can improve eye mobility in more than half of the patients.

Key words: traumatic strabismus, dystopia, orbital rupture, eyeball mobility, restriction, fibrosis
Sofia Gavrilova. Russia’s Regional Museums: Representing and Misrepresenting Knowledge about Nature, History, and Society. London: Routledge, 2022
Authors: Степанов Борис
Published: November 2024

Работа Софьи Гавриловой «Russia’s Regional Museums: Representing and Misrepresenting Knowledge about Nature, History, and Society» представляет собой смелую попытку разрешить парадокс, перед которым оказывается каждый исследователь российского краеведения. С одной стороны, повсеместность этого явления, туманность его истоков и многообразие форм всякий раз побуждает исследователя испытать, «как глубока кроличья нора». С другой стороны, в качестве локального знания изучение краеведения предполагает учет местной специфики, погружение в детали локальной истории и географии.
Текст на русском языке
«Сейчас запросы немножечко другие»: восприятие квир-персонажей в кино российскими зрителями
Authors: Алексеев Даниил , Мальков Максим
Published: November 2024

В статье исследуется восприятие молодыми российскими зрителями негетеросексуальных киноперсонажей. В работе мы задаемся вопросом: на каких аспектах репрезентации квир-персонажей в кино делается акцент молодыми российскими зрителями с гетеросексуальной и квир-идентичностью в свете собственного сексуального опыта зрителей и политического контекста, в котором зрители находятся? На основе методов качественного анализа, включающих полуструктурированные интервью с 14 молодыми людьми из Москвы, в исследовании рассматривается связь между личным опытом зрителей и их интерпретацией квир-образов в фильмах и сериалах. Нас интересует, как зрители декодируют нарративы о негетеросексуальных персонажах в кино. С опорой на концепты гетеронормативности и гомонормативности мы выделяем два типа репрезентации, которые, однако, не являются универсальными. В разных географических и социальных обстоятельствах эти категории могут трансформироваться и отражать разную связь политического контекста и опыта репрезентируемых групп. Гетеросексуальные зрители критически относятся к гетеронормативным образам, которые предполагают субординацию квир-персонажей, однако в меньшей степени критичны в отношении гомонормативной репрезентации. В отличие от них, квир-зрители критикуют оба типа репрезентации, выявляя несоответствие между кинонарративами и реальностью их жизни. Они выражают желание видеть в кино более близкие к аутентичным и более разнообразные образы, выходящие за рамки распространенных тропов трагичности и инаковости. Кроме того, в работе отмечается ограничение концептуального аппарата западных теоретиков применительно к российскому контексту. Так, элементы гомонормативной репрезентации, маркированные как деполитизирующие в американском контексте, приобретают в России политический заряд.
Статья на русском языке
Оценка патентных и продуктовых портфелей фармацевтических компаний при конкурентном анализе
Authors: С. В. Кортов , А. А. Каримова , Д. Б. Шульгин , А. В. Роднин
Published: November 2024

Высокая неопределенность среды фармацевтического рынка обосновывает актуальность использования прогностических методов анализа на основе открытых данных. Авторами предложен методический подход, предусматривающий построение патентного ландшафта в сочетании с категориальным анализом продуктового портфеля организаций. Практическая реализация предложенного подхода проиллюстрирована на примере анализа поведенческих моделей фармацевтических организаций, специализирующихся в области разработки и вывода на рынок противодиабетических препаратов. Полученные результаты позволяют сделать обоснованные выводы о моделях конкурентного поведения российских и зарубежных организаций, обладающих различной степенью локализации производственных мощностей, но специализирующихся на выводе аналогичной продукции на рынок, причем без использования коммерческих данных

The high uncertainty of the pharmaceutical market environment justifies the relevance of using predictive analysis methods based on open data. The authors propose a methodological approach that provides for the construction of the patent landscape in conjunction with a categorical analysis of the pharmaceutical organizations product portfolio. The practical implementation of the proposed approach is illustrated by analyzing behavioral models of pharmaceutical organizations specializing in the development and market launch of antidiabetic drugs. The results allow us to draw reasonable conclusions about the models of competitive behavior of Russian and foreign organizations that have different rank of production facilities localization without using commercial data
О некоторых предпосылках четвертой промышленной революции
Authors: В. П. Соловьев
Published: November 2024

В данной статье дается характеристика некоторых социально-экономических аспектов, связанных с процессами периодических технологических преобразований. Дается расширенное толкование инноваций для экономического роста и инноваций для экономического развития. Коротко характеризуются три промышленные революции. Более подробно описывается деятельность различных типов экономических агентов, которые принимали участие в реализации основных стимулов первой промышленной революции. Высказываются предположения о предпосылках четвертой промышленной революции. Как показывает практика, закономерности экономических отношений в период первых промышленных революций соответствуют пониманию социальной и экономической целесообразности современности

This article describes some of the socio-economic aspects associated with the processes of technological transformation. An expanded interpretation of innovation for economic growth and innovation for economic development is given. Three industrial revolutions are briefly characterized. The activities of various types of economic agents that took part in the implementation of the main incentives of the first industrial revolution are described in more detail. Assumptions are made about the premises of the fourth industrial revolution. As practice shown, the patterns of economic relations in that period correspond to an understanding of the social and economic feasibility of modernity
PEST-анализ как инструмент выявления возможных отраслевых сдвигов
Authors: В. Д. Маркова
Published: November 2024

В современной турбулентной внешней среде возрастает роль PEST-анализа, который предназначен для определения структурных сдвигов в отрасли под воздействием факторов макросреды и выявления на этой основе степени влияния заинтересованных групп, что необходимо для организации управления рисками. Однако компании практически не используют этот известный инструмент стратегического менеджмента, упуская формирующиеся тренды и возможности внешней среды. В статье обозначены методические проблемы использования PEST-анализа, выделены основные тенденции развития макросреды, на которые следует обратить внимание при проведении такого анализа. Описана организация PEST-анализа: от выявления значимых для отрасли трендов до заинтересованных в их реализации сторон с оценкой уровня заинтересованности и власти. Это позволяет системно представить возможные направления развития отрасли и создает основу для принятия обоснованных стратегических решений по развитию бизнеса

Contemporary turbulent environment is characterized by increasing role of Pest-analysis which is aimed to determine structural industrial changes as a result of macro factors influence and to indentify on this basis the level of influence of stakeholders’ groups; this is necessary for risk management organization. However companies practically don’t use this well known in-strument of strategic management missing existing trends and possibilities of external environ-ment. Methodical problems of PEST-analysis application are defined in the paper; main tenden-cies of macro environment development which should be taken into account under such analysis are highlighted. Organization of PEST-analysis is described starting from industry important trends’ indentifying including interested in their realization stakeholders with assessing of their power and motivation. As a result possible directions of industry’s development are presented in a systematic way and basis for reasonable strategic management decision making is created
Типы территориальных форм национальной инновационной системы США и их концентрация в городских агломерациях
Authors: В. Н. Минат
Published: November 2024

На основе использования типологического подхода выделены территориальные формы национальной инновационной системы США, сформировавшиеся под воздействием определенных условий в американском социально-экономическом пространстве. Исследование территориальной структуры национальной инновационной системы США в разрезе выделенных типов инновационных комплексов показало пространственную неоднородность инновационного процесса, протекающего в стране в настоящее время, обусловленную чрезвычайно высокой степенью концентрации НИОКР в городских агломерациях Соединенных Штатов Америки. Данная структура соответствует общенациональной и региональной тенденции комплексного развития американской инновационной экономики, пространственно представленной, прежде всего, различными формами научно-производственной интеграции (университетами, исследовательскими центрами, научно-технологическими парками и т. п.), формирующими, вместе с системой агломераций, территориальный каркас каждого инновационного комплекса США

Based on the typological approach, territorial forms of the national innovation system of the United States that were formed under the influence of certain conditions in the American socio-economic space are identified. The study of the territorial structure of the national innovation system of the United States in the context of the selected types of innovation complexes has shown the spatial heterogeneity of the innovation process taking place in the country at present, due to an extremely high degree of concentration of R&D in urban agglomerations of the United States. This structure corresponds to the national and regional trend of integrated development of the American innovation economy, spatially represented, first of all, by various forms of scientific and industrial integration (universities, research centers, science and technology parks, etc.), forming, together with the system of agglomerations, the territorial framework of each us innovation complex
Переход к новой экономической политике России: ответ на угрозы, вызовы и риски
Authors: Е. В. Ситников
Published: November 2024

В период пандемии с появлением новых угроз, вызовов и рисков особенно четко проявились ограниченные возможности используемых в настоящее время экономических теорий, моделей, форматов и подходов, поскольку они не обеспечивают экономический рост и на его основе повышение уровня и качества жизни, обостряют межстрановую конкуренцию, углубляют внутренние и внешние противоречия, социальное неравенство, лежат в основе военных конфликтов и новых видов гибридных войн. В работе рассматриваются новые ориентиры и цели, идеология, необходимая для их достижения, а также возможные подходы к новой экономической политике с использованием стратегического планирования, формированием новой экономической модели и совершенствованием управления научно-технологическим развитием - как главными факторами восстановления экономики и последующего роста в средне- и долгосрочном периодах

In the period of the pandemic, with the emergence of new threats, challenges and risks, the limited possibilities of currently used economic theories, models, formats and approaches have become particularly clear, since they do not provide economic growth and on its basis increase the level and quality of life, exacerbate inter-country competition, deepen internal and external contradictions, social inequality, are the basis of military conflicts and new types of hybrid wars. The paper considers new guidelines and goals, the ideology necessary to achieve them, as well as possible approaches to the new economic policy using strategic planning, the formation of a new economic model and improving the management of scientific and technological development - as the main factors of economic recovery and subsequent growth in the medium and long - term periods
Нефтегазовый комплекс России: сценарий развития
Authors: Л. В. Ларченко , Л. Г. Воробьева
Published: November 2024

В статье проанализировано современное состояние нефтегазового комплекса России в условиях санкций, падения цены на нефть, рассмотрены новые вызовы, связанные с катастрофическим снижением спроса вследствие вводимых ограничений из-за пандемии COVID-19. Рассмотрено взаимодействие России в рамках OPEC+ в целях стабилизации рынка углеводородов. В статье показано, что серьезной проблемой современного развития отрасли является состояние ресурсной базы российских компаний, которая характеризуется ухудшением структуры промышленных запасов, посколькубольшинство месторождений находится в стадии падающей добычи. Рассмотрены проблемы технологического оснащения отрасли. Сделано предположение дальнейшего изменения развития отрасли вследствие влияния пандемии COVID-19, согласно которому существующий до последнего времени сценарий развития трансформируется, структура энергетической отрасли в целом изменится в пользу низкоуглеродных источников. Для решения возникших вызовов необходимы крупные инвестиции в развитие современных технологий и цифровизации отрасли

The article analyzes the current state of the oil and gas complex of Russia under the conditions of sanctions, falling oil prices, considers new challenges associated with a catastrophic decrease in demand for restrictions introduced due to the COVID-19 pandemic. The interaction of Russia in the framework of OPEC+ in order to stabilize the hydrocarbon market is considered. The article shows that a serious problem of modern development is the state of the resource base of Russian companies, which affects the structure of industrial reserves that are in the stage of declining production. The problems of technological equipment of the industry are considered. An assumption has been made of a further change in the development of the industry due to the impact of the COVID-19 pandemic, according to which the development scenario existing until recently is being transformed, the structure of the energy industry as a whole will change in favor of low-carbon sources. To solve the challenges it is necessary to make large investments in the development of modern technologies, digitalization of the industry
Цифровые технологии реализации инвестиционных проектов в сфере водопроводно-канализационного хозяйства
Authors: И. В. Ильин , Д. А. Серов
Published: November 2024

В статье излагаются принципиальные пути применения цифровых технологий при разработке и реализации инвестиционных проектов в сфере водопроводно-канализационного хозяйства. Обосновывается необходимость комплексного подхода к цифровизации в рамках жизненного цикла инвестиционного проекта. Приводится описание применяемых цифровых технологий, и показывается их взаимосвязь. Раскрываются направления эффективности применения цифровых технологий

The article outlines the fundamental ways of using digital technologies in the development and implementation of investment projects in the field of water and sewerage utilities. The necessity of an integrated approach to digitalization within the life cycle of an investment project is substantiated. A description of the applied digital technologies is given and their relationship is shown. The directions of the effectiveness of the use of digital technologies are revealed
Имитационное моделирование как метод исследования элементов инновационной деятельности
Authors: Д. Б. Соловьев , С. С. Кузора
Published: November 2024

На протяжении последних лет исследованию инновационной деятельности уделяется особое внимание. Инновационный путь развития предполагает не только разработку новых технологий и выпуск высокотехнологичной продукции, но также и выстраивание эффективных механизмов взаимодействия участников, определение приоритетов и инструментов инновационной политики, оценку эффективности и результативности инновационной деятельности. Ввиду актуальности, исследовательская работа направлена на расширение возможностей имитационного моделирования инновационной деятельности средствами интерактивной системы MATLAB. Результатом практической части исследования выступает методика оценки элемента инновационной деятельности, способная учитывать потенциальные факторы влияния, которые воздействуют на инновационное развитие изучаемого субъекта

Over the past years, special attention has been paid to the study of innovation. The innovative development path involves not only the development of new technologies and the release of high-tech products, but also the development of effective mechanisms for interaction among participants, the identification of priorities and tools for innovation policy, and the evaluation of the effectiveness and efficiency of innovation. Due to its relevance, the research work is aimed at expanding the capabilities of simulation modeling of innovative activities using the MATLAB interactive system. The result of the practical part of the study is the methodology for assessing the element of innovative activity, capable of taking into account potential influence factors that affect the effectiveness of the studied subject
Значение особой экономической зоны «Санкт-Петербург» в обеспечении экономического роста города
Authors: Е. М. Ильинская , А. А. Капустин
Published: November 2024

В статье рассмотрены особенности особой экономической зоны (ОЭЗ) «Санкт-Петербург», проанализированы показатели ее деятельности за период с начала функционирования и отраслевая структура резидентов. На основе полученных данных сопоставлены экономические задачи города и возможности их достижения с использованием инструмента ОЭЗ, сделан вывод об эффективности ОЭЗ в целом и в части обеспечения экономического роста Санкт-Петербурга

The article examines the features of the Special Economic Zone (SEZ) «St. Petersburg», analyzes the indicators of its activities for the period since the beginning of operation and the sectoral structure of residents. On the basis of the data obtained, the economic objectives of the city and the possibilities of achieving them using the SEZ tool were compared, a conclusion was made about the effectiveness of the SEZ in general and in terms of ensuring the economic growth of St. Petersburg
О новых факторах влияния на деловую репутацию и стоимость компании
Authors: Б. Г. Киселев , Л. В. Кожитов , Л. С. Турилкина , А. В. Попкова , В. С. Верхович , В. Г. Бебенин
Published: November 2024

В связи с глобальным проникновением интернета во все сферы деятельности усилилось и ускорилось воздействие новых факторов, влияющих на деловую репутацию и стоимость компании. К этим факторам можно отнести фейки, медийные личности, социальные и профессиональные сети. В настоящей статье рассмотрены отдельные аспекты управления и защиты деловой репутации компании; определена роль рекламы в формировании деловой репутации; дан анализ вариантов сотрудничества компаний с медийными личностями для продвижения продукта компании; оценено влияние медийных персон на деловую репутацию, доходы компании и ее рыночную стоимость; приведены риски сотрудничества компаний с медийными лицами

Due to the deployment of the Internet into all areas of activity, the impact of new factors affecting the business reputation and value of the company has intensified and accelerated. These factors include fakes, public figures, social and professional networks. In this article certain aspects of management and protection of the company's business reputation are discussed; the role of advertising in the formation of business reputation is determined; an analysis of options for cooperation of companies with public figures in order to promote the company's product is given; the influence of public figures on the business reputation, the company's income and its market value was assessed; the risks of cooperation between companies and public figures are given
Перспективные средства спасения персонала из зон чрезвычайных ситуаций
Authors: М. Н. Охочинский
Published: November 2024

В статье рассматриваются перспективные системы спасения персонала из зон возникновения чрезвычайных ситуаций, в том числе природного и техногенного характера, основанные на применении реактивных средств доставки и эвакуации

The article considers promising systems for personnel rescue from emergency situations, including natural and man-made ones, based on the use of delivery and evacuation jet vehicles
Принципы и методы оценки рискообразующих факторов инновационно-инвестиционного проектирования в условиях цифровизации
Authors: О. Ю. Сыроватская , Н. В. Лашманова , И. А. Садырин
Published: November 2024

В современных условиях цифровой трансформации всех сфер экономики, большое внимание уделяется деятельности инновационных предприятий. И все чаще возникает необходимость использовать не только качественные, но «действенные» методы оценки рисков. В статье рассматриваются риски и рискообразующие факторы инновационно-инвестиционных проектов (ИИП) и методы их оценки, которые наиболее часто используются в условиях повышающейся неопределенности деятельности инновационных предприятий. Показана необходимость и целесообразность использования информационных систем при оценке рисков ИИП. Рассмотрен вопрос учета влияния рискообразующих факторов при формировании цены на ИИП. Показано, что при формировании стоимости ИИП целесообразно использовать в качестве стратегии управления рисками - их «принятие»

In the context of the transformation and digitalization of the economy, much attention is paid to the activities of enterprises engaged in innovative and investment design. And more and more often it becomes necessary to use not only high-quality, but «effective» methods of risk assessment. The article examines the types of risks of innovative investment projects (IIP) and methods of their assessment, which are most often used in the context of the increasing uncertainty of the activities of innovative enterprises. The necessity and expediency of using information systems in assessing the risks of IIP is shown. Considered the issue of accounting for the influence of risk-forming factors in the formation of prices for an innovative investment project. It shown that in the formation of the value of IIP it is advisable to use it as a risk management strategy - their «acceptance»
О российских вузах в глобальных рейтингах и не только о них
Authors: Е. Б. Виноградова
Published: November 2024

В статье рассмотрены некоторые исторические аспекты развития высшей школы в России, основные этапы и результаты селективной поддержки университетов за последние 15 лет, позиции российских вузов в глобальных рейтингах 2021 года. Предложены траектории дальнейшего развития системы организации, поддержки, контроля и оценки эффективности научной работы, кадровой и инновационной деятельности вузов по трем целевым направлениям и программам.

The article examines some historical aspects of the development of higher education in Russia, the main stages and results of selective support for universities over the past 15 years, the positions of Russian universities in the global rankings of 2021. The trajectories of further development of the system of organization, support, control and evaluation of the effectiveness of scientific work, personnel and innovation activities of universities in three target areas and programs are proposed
Система управления результатами интеллектуальной деятельности на предприятии
Authors: Е. В. Савиковская
Published: November 2024

Статья содержит изложение разработанной автором системы управления результатами интеллектуальной деятельности на предприятии, включающей реализацию четырех этапов и их периодическое повторение. Система является универсальной, соответствует общим принципам системного подхода

The article presents the system developed by the author for managing the results of intellectual activity at an enterprise, which includes the implementation of its four stages and their periodic repetition. The system is universal and complies with the general principles of the systematic approach
Влияние КОВИД-пандемии на развитие цифровой экономики
Authors: С. А. Дятлов , О. С. Лобанов
Published: November 2024

Мировая экономическая система в целом и экономики большинства стран мира испытали на себе шоковое влияние ковид-пандемии. Для оценки этого влияния представлена модель, которая позволяет проанализировать динамику распространения COVID-19 и выявить его влияние на традиционный и цифровой сектора экономики. Результаты моделирования представлены для временных рядов на основании данных по ковид-пандемии в Китае. Полученные результаты показывают отрицательную корреляцию кризисных факторов и экономического роста в целом и положительную корреляцию кризисных факторов и роста цифровой экономики. Это позволяет сделать фундаментальный вывод о негативных последствиях ковид-пандемии на экономический рост в традиционных отраслях, но и о позитивном влиянии ковид-кризиса на развитие секторов цифровой экономики

The global economic system as a whole and the economies of most countries of the world have experienced the shock impact of the corvette pandemic. To assess this impact, a model is presented that allows us to analyze the dynamics of the spread of COVID-19 and identify its impact on the traditional and digital sectors of the economy. The simulation results are presented for time series based on data from the covid pandemic in China. The results show a negative correlation between crisis factors and economic growth in general, and a positive correlation between crisis factors and the growth of the digital economy. This allows us to draw a fundamental conclusion about the negative effects of the covid pandemic on economic growth in traditional industries, but also about the positive impact of the covid crisis on the development of digital economy sectors
Development of first-in-class PROTAC degraders of TAK1
Authors: Strašek Benedik Nika , Bricelj Aleša , Suski Maciej , Zhu Dong , Sova Matej , Godyń Justyna , Więckowska Anna , Gütschow Michael , Steinebach Christian , Lv Dongwen , Gobec Martina , Sosič Izidor
Published: November 2024

Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is a serine/threonine kinase serving as a critical signaling node in cellular responses to various inflammatory stimuli. Dysregulation of TAK1-mediated pathways is commonly associated with inflammatory diseases and cancer, rendering TAK1 a promising pharmacological target for therapeutic intervention. In this study, we report the design and development of proteolysis-targeting chimeras (PROTACs) specifically tailored to degrade TAK1, offering a novel therapeutic approach for TAK1-related diseases. Takinib-based heterobifunctional compounds 11 and 16 induced potent, proteasome-dependent TAK1 depletion in tumor necrosis factor-alpha (TNF-α)-stimulated cancer cells. In cellular assays, these PROTACs demonstrated superior efficacy over takinib and its combination with corresponding E3 ligase ligands in reducing cancer cell viability and inducing apoptosis. The TAK1 degraders presented here provide valuable tools to further investigate the biological roles of TAK1 in diverse pathological and physiological contexts.
The level of pregnancy and childbirth complications among the residents of front-line city of Kharkiv
Authors: Lakhno I.V.
Published: November 2024

Background. The city of Kharkiv has been located in the area of armed conflict or the front-line zone since the beginning of the invasion of Russian troops. A part of the female reproductive-aged population constantly remains in Kharkiv which determines the possible negative impact of wartime stress.

The purpose – of the work was to study the level of pregnancy and childbirth complications among women living in Kharkiv.

Materials and Methods. A retrospective observational study was conducted based on the materials of the municipal non-commercial enterprise «Municipal Perinatal Center» of the Kharkiv City Council. All the examined contingent was divided into three groups. 2914 women who gave birth in 2021 were included in Group I. There were 956 patients in Group II whose pregnancies were completed in term via childbirth in 2022. Group III included 1288 women who gave birth in 2023. The study was conducted by studying the cards of pregnant women in the computer-automated system of the perinatal center

Results. The level of thyroid diseases was likely to increase in 2022 compared to the prior level. In 2023, the upward trend continued. A probable increase in the incidence of diabetes mellitus in pregnant women in 2023 compared to the data of 2021 was detected. Interestingly, the level of anemia and cardiovascular diseases remained stable. However, a significant increase in the urinary system’s infectious processes was established in 2023 compared to previous years. Unfortunately, a substantial increase in the level of maternal trauma during childbirth has been established. This was especially true concern on vaginal and cervical tears. Therefore, sanitation of the urogenital system can be the key to reducing maternal trauma during childbirth.

Conclusions. During the military operations, an increase in the level of medical complications among pregnant women in the city of Kharkiv was noted due to a rise in some endocrine diseases and urinary tract infections. The increase in the prevalence of vaginal infections has led to a rise in the rate of vaginal and perineal ruptures. This requires an emphasis on infection monitoring and timely sanitation of the birth canal. The use of preventive measures made it possible to keep the level of major obstetric syndromes such as premature births, and pre-eclampsia, as well as the level of childbirth complications quite stable. The established features should become the basis for further work in the direction of reducing the negative consequences of military aggression on the health of pregnant women in the city of Kharkiv.
Evaluation of nutrition of young children in Odesa district
Authors: Sopel О.М. , Denefil О.V.
Published: November 2024

Background. The main factor that ensures the health and harmonious development of a child, both in the early stages and in the later periods of his life, is rational nutrition. The widespread prevalence of food-dependent forms of pathology among children, insufficient awareness of doctors and parents, as well as violations in the organization of nutrition of young children determine the relevance of this work and the need for a comprehensive analysis of the actual nutrition of children aged 1 to 2 years for its improvement.

Purpose – to purpose of the work is to establish the nutritional characteristics of children aged from 1 to 2 years in order to optimize their diets.

Materials and Methods. 42 healthy children aged 1 to 2 years who lived in Odesa district took part in the study. In work were used such methods: clinical and anamnestic; dietary; anthropometric – height, weight; sociological – questionnaires; statistical.

Results. The patterns of food organization and consumption of the main macronutrients by children aged 1 to 2 years are formulated, which are characterized by adequate consumption of basic food products, with the exception of excessive consumption of cheese, fruit juices and hard cheese and insufficient use of enriched industrial products. It is shown that excessive amounts of food, inadequate nutrition in the form of multiple snacks and sometimes night feedings, as well as unreasonable use of products not intended for children aged 1 to 2 years, are significant violations of the organization of nutrition of children of this age group. It was established that the diets of children aged 1 to 2 years are unbalanced in terms of the content of proteins, fats, and carbohydrates. Identified violations of the nutrition structure of young children, its imbalance in terms of macronutrient composition dictate the need for regular control by pediatricians and family doctors over the organization of nutrition for children of this age period.

Conclusions. The nutrition structure of children aged 1 to 2 years is characterized by an imbalance of rations in terms of proteins, fats, and carbohydrates, which is due to violations of the feeding regime, overeating, and early transition to the «family» food-table. Young children consume excessive amounts of protein and fat compared to recommended physiological norms and insufficient amounts of carbohydrates according to their age.
The effects of a schoolbag load carriage on gait kinematics in children
Authors: Jenčíková Kateřina , Kasović Mario , Zvonař Martin
Published: November 2024

The main purpose of this study was to explore the impact of carrying a school bag on spatiotemporal gait parameters in a sample of primary school children. Two-hundred and twenty-one children (124 girls and 97 boys), aged 9.5±2.1 years, were randomly selected from three primary schools in the city of Brno, Czech Republic. Gait analysis without and with the school bag load carriage was performed using the Zebris pressure platform. The software generated the data for spatial (foot rotation, step length, stride length and step width) and temporal (step time, stride time, cadence and gait speed) gait parameters. The mean school bag weight was 4.86±1.21 kg. Repeated measures ANCOVA adjusted for sex and age showed that carrying a school bag resulted in a higher external left foot (F1,220=8.390, p<.001) and right foot (F1,220=8.791, p<.001) rotation, narrow step width (F1,220=6.113, p<.001), longer left foot (F1,220=5.556, p=.011) and right foot (F1,220=4.508, p=.021) step time, longer stride time (F1,220=3.773, p=.035), less cadence (F1,220=3.773, p=0.038) and slower gait speed (F1,220=4.131, p=.029). Carrying a school bag weight may change gait characteristics in schoolgoing children, especially in temporal parameters.
The New Zealand Ministry of Health indicators for inpatient stroke care: results from an Auckland hospital
Authors: Karasinska-Stanley Zofia , Jayanatha Kalpa , Wong Edward , Kar Arindam
Published: November 2024

aim: New Zealand’s Ministry of Health sets three quality metrics for inpatient stroke care: admission to an organised stroke unit within
24 hours (target 80%), appropriate use of reperfusion therapy (target 12% for ischemic stroke) and transfer to rehabilitation services
within 7 days (target 80%). Our aim was to evaluate a large Auckland tertiary hospital’s performance against these indicators.
methods: A retrospective study of 200 consecutive stroke patients admitted between April 4 and August 1, 2021, was conducted.
results: Fifty percent (100/200) of patients were admitted to the stroke unit within 24 hours. Sixteen point six percent (27/183) of
ischaemic stroke patients received reperfusion therapy. Twenty-four point five percent (49/200) were transferred to rehabilitation
services, of which 40.8% (20/49) were within 7 days of presentation. Patients were less likely to be admitted to the stroke unit within
24 hours if not admitted by the stroke service, if admitted out-of-hours or if suffering an inpatient stroke. Timely admission to the
stroke unit was associated with receipt of reperfusion therapy, shorter time to inpatient rehabilitation transfer and shorter duration of
admission. Patients with inpatient stroke were less likely to be discharged in a timely manner (adjusted hazard ratio [HR] 0.19; 95%
CI 0.07–0.50). All-cause mortality during a hospitalisation episode with a stroke diagnosis was likely to occur early in the admission
(adjusted HR 1.82; 95% CI 1.01–3.32).
conclusions: The hospital met the reperfusion therapy target but fell short on timely stroke unit admission and rehabilitation
transfer. An after-hours effect on stroke unit admission was observed, previously undocumented in New Zealand.
The impact of surgical time of day and surgical site infection
Authors: Cumin David , Cheeseman James , Warman Guy
Published: November 2024

Disruption to the circadian clock has impacts on health and wellbeing, including impaired immune function and wound healing. It is
plausible that the timing of surgical procedures could impact the body’s response to trauma and susceptibility to infections. Using
the Health Quality & Safety Commission data on surgical site infections (SSI) we sought to investigate any possible time of day effects
on the incidents of recorded infections. All recorded data from June 2017 to July 2021 were extracted for cardiac and orthopaedic
operations in New Zealand. The incidence of SSI was calculated for each 4-hour bin of time across the day. There was a total of 87,034
cases in the analysis, of which 1,327 (1.5%) had an infection. Univariately, there was a significant time of day effect, with operations
after 8 pm being 3.91 times more likely to have an infection (p<0.001), and operations between 4 pm and 8 pm being 0.71 times more
likely (p=0.03) to have an infection compared to operations conducted between 12 pm and 4 pm. However, when age, acuity and
American Society of Anesthesiologists scores were included in the model, there were no differences in the rate of infection by time of
day. This preliminary work suggests that surgical time of day does not significantly impact incidence of surgical infection when other
variables are controlled for. However, this work has not considered other factors that may also be important. We plan to link the SSI
data with the National Minimum Dataset to investigate these other factors and conduct a more comprehensive analysis.
Innovative Nanoparticle Synthesis and Multifaceted Applications in Medicine and Cancer Therapy
Authors: Aftab Zartasha , Bukhari Syed Muhammad Ahmad , Abubakar Muhammad , Sultan Hafiz Muhammad , Zubair Muhammad , Abou El Niaaj Maysoon Ahmed
Published: November 2024

Nanotechnology has far-reaching implications and applications in multiple fields. The biomedical and health sectors can use nanotechnology concepts for medication delivery and treatment. Under controlled conditions, it can target and initiate administering drugs and several other therapeutic agents. Since cancer is the largest cause of death worldwide, prompt diagnosis and effective anticancer treatments are crucial. In this particular context, nanotechnology reduces side effects and directs drug delivery to specifically target cancer cells, providing unique benefits for cancer therapy. In the present thorough review, the most noteworthy new findings for 2010–2023 were compiled, which address the development and use of nanosystems for cancer treatment. Nanoparticles allow precise and controlled release of therapeutic substances at specific action locations, enabling targeted medication delivery. Size, shape, surface, charge, and loading methods impact its efficiency. Researchers have made advancements in encapsulating drugs into nanoliposomes and nanoemulsions, including paclitaxel and fisetin, and are currently testing their suitability in ongoing clinical trials. The purpose of this review is to serve as a continuous path toward recognizing the extraordinary potential of various nanoparticles in cancer therapies.