bluuebunny/crossref_metadata_2025 huggingface dataset:
Succinic Acid Production from Monosaccharides and Woody and Herbaceous Plant Hydrolysates Using Metabolically Engineered Corynebacterium glutamicum
Authors: Lee Dae-Seok , Cho Eun Jin , Kim Seryung , Nguyen Dien Thanh , Bae Hyeun-Jong
Published: February 2025

Research background. Succinic acid derived from lignocellulosic biomass presents a sustainable alternative for biochemical production, providing eco-friendly substitutes for petroleum-based chemicals. This study aimed to evaluate the impact of variations in hemicellulose content and cellulose fiber structure within the microfibrils of woody and herbaceous plants on the enzymatic saccharification and succinic acid production efficiencies of Psod:SucE12-ΔldhA, a strain overexpressing the succinic acid transporter (SucE).
Experimental approach. The study investigated the influence of different monosaccharide combinations on succinic acid production, focusing on combinations including mannose compared to glucose alone. Additionally, hydrolysates from various lignocellulosic biomass—bamboo, oak, poplar, pine, and spent coffee grounds—were analyzed to determine the most favorable bioresource for succinic acid production.
Results and conclusions. Monosaccharide combinations containing mannose resulted in 2.20-2.48 times higher succinic acid production than glucose alone, indicating a positive influence of mannose on succinic acid metabolism. Among the lignocellulosic biomass hydrolysates, bamboo, with its higher xylose content compared to woody plants, was the most efficient bioresource for succinic acid production (23.38–24.12 g/L within 24 h), followed by oak, poplar, pine, and spent coffee grounds. Therefore, improving the xylose consumption rate is crucial for enhancing succinic acid production from lignocellulosic biomass and increasing market competitiveness.
Novelty and scientific contribution. This research highlights the potential of lignocellulosic biomass, especially bamboo, as a sustainable feedstock for succinic acid production. The novelty of the study lies in its detailed examination of how hemicellulose content and cellulose fiber structure affect enzymatic saccharification and fermentation. The significant impact of mannose and xylose on succinic acid yields provides key insights for optimizing biomass use in biochemical production. These findings advance bio-based chemical manufacturing, reducing reliance on fossil fuels and enhancing industrial sustainability.
The effect of caregiver training in increasing social interaction and contact time with children living in residential care facilities
Authors: Koch Lyndsay , Franzsen Denise
Published: February 2025

Infants and toddlers living in residential care facilities are at risk of developmental delay. Environmental factors contributing to this risk are the temporal context (how children spend their time) and social context (how and when caregivers interact with the children).  this study compared time-use patterns of children living in residential care facilities where caregiver training had previously taken place versus those in facilities where caregiver training had not taken place using a non-experimental, cross-secctional static group comparison study design. Spot observations were used to estimate time-use patterns of infants and toddlers living in residential care facilities in Johannesburg, South Africa.Results show that caregiver training positively changed the quantity of the time that infants spent with their caregivers (temporal context) and the quality of time toddlers spent with their caregivers (social context). Thus caregiver training has the potential to improve the environment in residential care facilities and can be used as an intervention strategy by occupational therapists.
Key words: Residential care facilities, time-use patterns, caregiver training, quantity of time spent caregiving, quality of time spent caregiving
CRISPR Detect for Evercode™ WT v2 v1
Authors: Biosciences Parse
Published: February 2025

CRISPR Detect enables analysis of single guide RNAs (sgRNAs) in studies using CROP-seq or similar methods. Compatible methods generate a polyadenylated transcript containing the sgRNA sequence downstream of a human U6 promoter. When CRISPR Detect is combined with Evercode WT v2, paired sgRNA detection and whole transcriptome expression can be analyzed in up to 100,000 cells across up to 48 different biological samples or experimental conditions. Evercode Cell Fixation kits convert the cells into individualized reaction compartments, thus avoiding the requirement for dedicated microfluids hardware. Through three rounds of barcoding, the transcriptome of each fixed cell is uniquely labeled. In each round, pooled cells are randomly distributed into different wells, and transcripts are labeled with well-specific barcodes. During cDNA amplification, barcoded transcripts are amplified, and sgRNA containing polyadenylated transcripts are enriched with human U6 specific primers. Amplified cDNA is split to create Whole Transcriptome and CRISPR sequencing libraries. After sequencing, the Parse Biosciences Analysis Pipeline assigns reads that share the same four barcode combination to a single cell and associates sgRNAs to the appropriate cell. For additional details on the molecular mechanisms core to the Evercode and CRISPR Detect technology, see Appendix B.
High-Performance Protocol for ONT Library Preparation v1
Authors: Žemaitis Lukas , Palepšienė Rūta , Juzėnas Simonas , Alzbutas Gediminas , Burgi Pierre-Yves , Galminas Ignas
Published: February 2025

This protocol presents a refined version of the Oxford Nanopore Technologies (ONT) Ligation Sequencing amplicons V14 (SQK-LSK114) protocol, optimized for the sequencing of short and ultra-short DNA fragments. It maintains the use of reagents required for standard ONT library preparation while enhancing DNA yield and improving sequencing performance. The protocol can be successfully used for all types of Flow Cells, but the Flow Cell priming and loaded library volumes must be adjusted accordingly.
SnackerTracker v1
Authors: Mueller Marissa , Tir Selma , Pothecary Carina , Meijer Elise , Brown Laurence , Foster Keiran , Vyazovskiy Vladyslav , Peirson Stuart , Molnar Zoltan
Published: February 2025

Accurately measuring activity and feeding is frequently important in laboratory animal research, whether for welfare-monitoring or experimental recording. Quantification commonly involves manual pellet-weighing; however, this can physically disturb animals and cannot continuously assess both the amount and pattern of feeding. Improved means of food-intake measurement have been developed yet are often costly and incompatible with cage configurations. We therefore developed and validated the SnackerTracker—a cost-effective, open-source, and user-friendly measurement system which continuously records food-intake, food-seeking activity, and ambient light conditions in the home-cages of small laboratory animals. This protocol describes how to build and operate the SnackerTracker, including device initialisation, data collection, and analysis.
JGI/LBNL Metabolomics - Standard LC-MS/MS ESI Method - Lipids v1
Authors: B. Louie Katherine , Faltane Meghana , Lynde Marie , P. Bowen Benjamin , Northen Trent
Published: February 2025

This protocol describes the standard LC-MS/MS ESI method developed at Lawrence Berkeley National Laboratory (LBNL) by JGI Metabolomics to analyze lipids (e.g. TAGs, DAGs, SQDG, betaine lipids such as DGTS, galactolipids such as MGDG and DGDG, glycerophospholipids such as PC, PE, PS, etc), carotenoids, pigments, and other lipid-like compounds from sample extracts using reverse phase chromatography (C18) coupled to a Thermo Orbitrap Mass Spectrometer with ESI source. This robust method of detection is easily reproduced and adapted onto similar LC-MS/MS systems to achieve consistent outcomes across mass spectrometry datasets, foster inter-lab and inter-experiment comparability, and enable effective data integration and analysis. Since its inception in 2015, this method has been used to analyze thousands of experimental samples, with many of these datasets publicly available in the MassIVE data repository1,2 and analyzed through the GNPS/GNPS2 mass spectrometry analysis hubs3,4.
Cossack baroque as a state historical and cultural style: formation and dynamics of development
Authors:   State University of Infrastructure and Technologies, Kyiv, Ukraine, Pohribna Daria
Published: February 2025

Background. The crisis situation in the contemporary Ukrainian socio-humanitarian space requires reflections on cultural facts from the past, aiming to reassess their impact on the present. The purpose of the research is to analyze Cossack baroque as a state-oriented historical and cultural style and to determine the extent of its influence on the history and culture of Ukraine, as well as to reveal its relevance in contemporary society. Research tasks that are necessary for achieving this aim relates to identifying the preconditions for the formation and development of baroque as a Cossack state style of the 17th-18th centuries, and justification of its relevance for contemporary societal development.

Methods. As a methodological toolkit are used following methods: the unity of logical and historical, historical-genetic, comparative, historical reconstruction, socio-cultural, and systemic analysis.

Results. Baroque as a cultural style with its characteristic features (emotionality, dynamism, metaphoricality, complexity, grandeur) arose in Western Europe and received a creative reception in Western Ukrainian lands. However, as an authentic historical and cultural style, baroque is manifested in the Cossack-Hetman state and is a consequence of the development of the Ukrainian intellectual tradition. The Ukrainian Baroque style, which the author equates with the Cossack Baroque, became not only a reflection of the psychological and mental features of the Ukrainian people, but also an expression of the Hetmanship state idea. The Cossack elder, as the elite of Ukrainian society, was both a bearer of artistic tastes and a customer of works in the Cossack Baroque style. The artistic monuments of the Cossack Baroque combine magnificence, grandeur, dynamism, metaphoricality and accumulate state narratives.

Conclusions. The Cossack Baroque phenomenon is not only a reception of the Western European Baroque, which embodies the features of the Ukrainian worldview of the 17th and 18th centuries, but also an authentic Ukrainian state style of the Hetmanship era. Preservance of the Cossack Baroque era monuments to this days testifies to the existence of a state culture in the 17th – 18th centuries, which formed the value guidelines for the development of Ukraine as a state. Based on the results of a critical analysis of the scientific works of modern cultural scholars, the author defines Baroque not only as the dominant style of Ukrainian culture, but also as the state style of the Cossak-Hetman state, which determines the greatest significance of Cossack Baroque for the history of Ukrainian culture.
Contribution of clinical pharmacy to the rational and safe use of medicines in the neonatology unit of the pediatric university hospital Charles de Gaulle of Ouagadougou, Burkina Faso
Authors: Ouedraogo Moussa , Pagbelguem Bonsdawindé , Nikiema Arsène Wendwaoga , Sombié Charles B. , Ouedraogo Emile W. , Zoungrana Colette , Nagalo Kisito , Kabore Aïssata
Published: February 2025

Background: Newborns are exposed to drug therapeutic risks due to off-label prescribing and immaturity. The purpose of this study is to identify drug-related problems through the prescription and administration of drugs in the neonatology Unit and identify the need for pharmaceutical interventions.
Methods: To assess drug-related problems, a cross-sectional observational study was conducted over five days at the neonatology Unit of the Pediatric University Hospital Charles de Gaulle in Burkina Faso. The study population consisted of newborns receiving drug prescriptions and treatment for five days.
Results: Prematurity (50%) and early neonatal infection (53.3%) were the most common reasons for admission. A total of 380 prescription lines were recorded. Injectable and oral forms represented 72.1% and 26.3% respectively. Prescription lines in 16.8% were off-label medicines. An accuracy of drug dosages at 6.1% and an accuracy of prescribed doses at 52.7%, characterized therapeutic regimens. The prescribed drug administrations were performed in 80.0% with compliant doses and administration scheduled time 1 hour in 53.4 % and 54.6 %, respectively. Prescribers and nurses accepted 92.6% and 93.9% of proposed pharmaceutical interventions to solve drug-related problems.
Conclusion. Our study emphasizes the importance of a clinical pharmacist within the health care team for the safe and efficient prescription and administration of newborn medication.
Prospective observational study of blood pressure variation and malnutrition using body composition monitor in hemodialysis patient in tertiary care hospital
Authors: Hussain Shuaib , George Blessy K. , Ramaiah Balakeswa
Published: February 2025

Background: Blood pressure (BP) variations and malnutrition are critical concerns in hemodialysis patients, significantly impacting morbidity, mortality and quality of life. Accurate assessments using tools such as the Body Composition Monitor (BCM) can guide effective interventions to improve outcomes. This study aimed to evaluate BP variations and malnutrition in hemodialysis patients using BCM, analysed dialysis-related complications and assess the impact of targeted interventions on patient outcomes.
Methods: A prospective observational study was conducted on 125 hemodialysis patients at a tertiary care hospital. Data on BP variations, nutritional status and complications were collected using BCM and the Medical Outcomes Study Short Form-36 (MOS SF-36) questionnaire. Pharmacological and non-pharmacological interventions were tailored based on findings. Follow-up data assessed changes in body composition and complication rates.
Results: Hypertension was the most prevalent BP variation (63.2%), followed by hypotension (26.4%) and intradialytic hypotension (IDH) (8%). Malnutrition affected 24.8% of patients, primarily older males. During follow-up, patients with normal indices of lean tissue (28 to 54), fat tissue (28 to 54) and BMI (28 to 54) increased significantly. The most common dialysis-related complications were cramps (43.2%), itching (28%) and edema (20.8%). Targeted interventions, including nutritional supplementation and BCM-guided fluid management, reduced complications and improved nutritional and hemodynamic parameters.
Conclusions: The study highlights the high prevalence of hypertension and malnutrition among hemodialysis patients and underscores the utility of BCM in optimizing patient management. BCM-guided interventions were associated with improved nutritional status and reduced complications, emphasizing the need for individualized care strategies. Further multicenter studies are recommended to validate these findings and expand their applicability.
A prospective study to assess the usage of intravenous fluids in patients presenting to the emergency department
Authors: Agrahari Sonaxi , Sinha Abhishek Kumar , Sapkota Kreeti , Greorge Blessy K. , Ramaiah Balakeshwa
Published: February 2025

Background: Intravenous (IV) fluid therapy is a common and critical component in the emergency management of patients. However, inappropriate prescribing and management of IV fluids can result in adverse outcomes.
Methods: This was a prospective observational study involving 132 patients who received IV fluids in the ED. The type of IV fluids, indications, infusion rates and the demographic characteristics of patients were recorded and analyzed.
Results: Out of 132 patients, 80 were female and 52 were male. The most frequently used fluid was Normal Saline (NS) (81%). The primary indication for IV fluid administration was hydration (63.50%). Infusion rates were most commonly bolus infusions (86.13%).
Conclusions: The study revealed that the majority of patients were administered IV fluids for hydration, with NS being the most common fluid. Proper education on fluid management in the ED can improve patient safety and treatment outcomes.
Assessment of predisposing factors and prescribing pattern in coronary artery disease patients at a tertiary care hospital of Southern Rajasthan
Authors: Purohit Ayushi , Sharma Sourabh
Published: February 2025

Background: Coronary artery disease (CAD) is the leading cause of mortality globally. The risk factors for the development of cardiovascular disease include lifestyle changes, diabetes mellitus, hypertension, smoking, hyperlipidemia, obesity and psychosocial stress. Drug regime plays an important role in declining the untimely deaths and enhances the quality of life. Few studies have been done on the prescribing patterns of CAD; hence the main objective of the study was to scrutinize various risk factors and therapy patterns for CAD patients.
Methods: A non-interventional prospective study was conducted among 120 patients, to assess the risk factors and prescribing pattern in CAD patients. Information regarding patients was recorded in data collection form. Data was statistically analyzed using IBM statistical package for the social sciences (SPSS) software.
Results: Majority of the patients were male (77.5%). Most of the patients (59.20%) were in age range of 50-69 years. Most common co-morbidities found were hypertension and diabetes. Body mass index (BMI), tobacco chewing, smoking were major risk factors. Majorly prescribed drugs were antiplatelets, anticoagulants, statins, antibiotics, nitrates, antihypertensive, PPI’s and analgesics. Average number of drugs encountered per prescription was 8.70. While number of encounters with a drug indicated in CAD was 5.66. Number of drugs prescribed with an injection and generic name were 4 and 1 respectively. As per DDD calculation, Heparin was consumed in highest amount.
Conclusions: Polypharmacy was practiced. Generic prescribing was low. Major risk factors included BMI, tobacco chewing, smoking, diabetes and hypertension. Findings of this study can be used to develop a framework for ongoing prescription assessment in a healthcare setting.
Individual component analysis of gastrointestinal symptom rating scale for irritable bowel syndrome in irritable bowel syndrome patients treated with Bacillus coagulans SNZ 1969: additional findings from a randomized, double-blind, placebo-controlled study
Authors: P. V. Kishan , Soman Raunak J. , Soman Dhruv , Gorantla Sarath Chandra
Published: February 2025

This study evaluated the therapeutic efficacy of Bacillus coagulans SNZ 1969 (B. coagulans SNZ 1969) in patients with constipation-predominant irritable bowel syndrome (IBS-C) and diarrhea-predominant IBS (IBS-D). We conducted a randomized, double-blind, placebo-controlled trial in 80 patients (40 IBS-C, 40 IBS-D) who received either B. coagulans SNZ 1969 (500 million CFU) or placebo twice daily for 60 days. Assessments were performed at baseline and on days 30, 60, and 75. Here we present the additional findings of the individual components of Gastrointestinal Symptom Rating Scale for IBS (GSRS-IBS). Results demonstrated significant reductions in all individual components of GSRS-IBS (abdominal pain, bloating, constipation, diarrhea, and satiety) in both IBS-C and IBS-D patients treated with B. coagulans SNZ 1969 compared to placebo. In conclusion, B. coagulans SNZ 1969 found to be an effective therapeutic option for IBS, demonstrating broad efficacy across multiple symptom domains.
Potential of Coriandrum sativum in management of diabetes and hyperlipidemia: a comprehensive review of pharmacological evidence and mechanisms
Authors: Y. R. Sanjaya Kumar , Lamba Deepak , Khanduri Shruti , N. Srikanth
Published: February 2025

Diabetes mellitus, obesity, and hyperlipidaemia are interconnected metabolic disorders with rising prevalence worldwide, posing significant public health challenges. These conditions often coexist, forming a metabolic syndrome characterized by elevated glucose levels, excess body fat, and abnormal lipid profiles, leading to severe complications such as cardiovascular diseases and organ dysfunction. Coriandrum sativum (coriander), a culinary herb with a long history of medicinal use in traditional systems like Ayurveda, has shown promising therapeutic potential in managing these metabolic disorders. Rich in bioactive compounds such as flavonoids, polyphenols, and essential oils, coriander exhibits antidiabetic and antihyperlipidemic activities. Its efficacy has been demonstrated in various experimental models of diabetes and Hyperlipidemia, with significant reductions in blood glucose levels, lipid parameters, and oxidative stress markers. The mechanisms underlying these effects include stimulation insulin secretion, inhibition of α-glucosidase activity, modulation of lipid metabolism, and antioxidant activity. This review comprehensively evaluates the pharmacological actions and mechanisms of coriander, including its seed and leaf extracts, essential oils, and dietary incorporation, in mitigating hyperglycaemia, dyslipidaemia, and obesity-associated complications. By integrating traditional knowledge with modern scientific evidence, this article highlights the therapeutic potential of Coriandrum sativum as a natural remedy for addressing the escalating burden of metabolic disorders.
Comparative analysis of tension band wiring and cannulated cancellous screws for displaced medial malleolus fractures: a prospective study
Authors: C. Karthik Aiyanna N. , K. Deekshith Shetty , Swamy Manjunath , Kailath Kiran J.
Published: February 2025

Background: The displaced medial malleolus fractures require surgical intervention, and the management includes tension band wiring (TBW) and cannulated cancellous screws (CCS).
Methods: This prospective randomized study was conducted from December 2019 to December 2022. Sixty patients with closed displaced medial malleolus fractures were randomized into two groups: group A (TBW) and group B (CCS). Patients were evaluated based on radiological fracture union and functional outcomes assessed using the modified Olerud and Molander ankle score (OMAS). Follow-ups were conducted for two years to assess healing, range of motion, complications, and functional outcomes.
Results: Mean age was 41.46 years in group A (TBW) and 39.4 years in group B (CCS). Radiological union was achieved faster in group B (10.4 weeks) compared to group A (11.53 weeks, p=0.003). Functional outcomes showed excellent scores in 16.67% of group A patients and 30% of group B patients. Group B had fewer complications, with only one case of screw loosening compared to a higher rate of hardware prominence (30%) and exertional pain (10%) in group A, necessitating implant removal in 12 patients. No significant differences in range of motion were observed, although group B demonstrated slightly better functional outcomes.
Conclusions: Both TBW and CCS effectively achieve fracture union in displaced medial malleolus fractures. However, CCS fixation demonstrates superior functional outcomes, faster union rates, and fewer complications compared to TBW. Lower risk of hardware-related issues and reduced need for secondary surgeries, CCS is recommended as a preferred method for the surgical management of displaced medial malleolus fractures.
Role of physiotherapy in relieving osteoarthritis knee pain using Lysholm score
Authors: Khatod Garvit , Butala Rajendraprasad Ramesh , Das Sonali
Published: February 2025

Background: Knee osteoarthritis (OA) is a prevalent condition that significantly impacts quality of life. While pharmacological interventions are commonly used, non-pharmacological approaches like physiotherapy have gained increasing recognition. In this study, the Lysholm Knee Scoring Scale was used to assess how well physiotherapy worked in reducing knee pain and enhancing functional results for people with OA knee.
Methods: A randomized controlled trial from  1st February 2023 to 31st July 2023 at Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College and Hospital, Nerul, Navi Mumbai, Maharashtra, India was conducted with 500 participants diagnosed with knee OA. Participants were randomly assigned to either the physiotherapy group (n=250) or the control group (n=250). The physiotherapy group received a 12-week standardized program consisting of exercise therapy, manual therapy and education. The control group received standard care. The primary outcome was the Lysholm Knee Scoring Scale, assessed at baseline, 12 weeks (post-intervention) and 24 weeks (follow-up). Secondary outcomes included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), knee range of motion, muscle strength and quality of life.
Results: At baseline, the groups were comparable in terms of age, gender, body mass index and clinical characteristics. The physiotherapy group demonstrated significantly greater improvements in the Lysholm Knee Scoring Scale compared to the control group at 12 weeks (mean difference: 10.2, 95% CI: 7.4, 13.0; p<0.001) and 24 weeks (mean difference: 12.2, 95% CI: 9.2, 15.2; p<0.001). Similar patterns were observed for secondary outcomes, with the physiotherapy group showing significant improvements in WOMAC pain and function, knee range of motion, quadriceps strength and quality of life (all p<0.001).
Conclusions: This study provides evidence that physiotherapy interventions, including exercise therapy, manual therapy and education, are effective in relieving knee pain and improving functional outcomes in individuals with knee osteoarthritis, as measured by the Lysholm Knee Scoring Scale and other relevant clinical measures.
Static antibiotic loaded cement spacer application in 2-stage management of native and prosthetic hip joint infections: a case series and review of the literature
Authors: Ayekoloye Charles I. , Balogun Mosimabale J. , Alonge Temitope O.
Published: February 2025

Two-stage revision including interval cement spacer application is the gold standard treatment for both prosthetic and native hip infection with joint destruction. We present a summarised case series of our experience of successfully treating 8 infected joints in 6 patients treated with 2-stage revision using interval static spacers. Two patients with 3 native joint infections and 4 patients with 5 prosthetic joint infections were treated with 2-stage arthroplasty with interval static spacer application consisting of static block spacers or cement beads. There were 2 females and 4 males. Mean age is 40.5 years and range 24-60 years. Mean interval between the first and second stage is 8weeks. One case has not undergone the second stage as he is unable to fund the operation. Organisms cultured include methicillin- sensitive staphylococcus aureus, enterococcus. All underwent cementless hip reconstruction with one patient undergoing hybrid hip reconstruction. At mean 36-month follow-up (range 30-44 months) all patients have normalized inflammatory markers and improvement in Oxford hip score (OHS) from pre-operative mean 16.6 (range 15-19) and post-operative mean OHS 43.7 (range 35-50). Patients continue to be followed up. We recommend this cement spacer option as part of a 2-stage procedure when faced with moderate to severe acetabular bone loss. It is effective in treating native or prosthetic hip joint infections and joint infections in patients with sickle cell haemoglobinopathy.
A rapidly advancing intraosseous angiosarcoma masquerading as an infected pathological periprosthetic fracture: a case report
Authors: Fong Jiawen , Boo Ho Chin
Published: February 2025

We present a case of a rapidly progressive angiosarcoma that presented initially as a pathological fracture in our institution after a fall. Mdm A, a 74-year-old Chinese lady initially presented with non-specific thigh pain prior to an unwitnessed fall, following a recent bipolar hemiarthroplasty 3 months before current presentation. Blood markers were grossly within acceptable limits and computed tomography (CT) scan revealed displaced greater and lesser trochanteric periprosthetic fractures with subsidence of femoral stem, and findings suggestive of intramuscular haematomas. She subsequently turned septic on day of planned surgery for a revision arthroplasty with markedly raised inflammatory markers. Revision surgery was postponed, with repeat imaging noting evolving fluid collections suspicious of an infected prosthetic joint infection (PJI). Joint washout for presumptive PJI performed 1-week later yielded negative histopathology and cultures. She developed respiratory compromise a few days later. CT-thorax revealed bilateral pleural effusions with small spontaneous haemo-pneumothoraces which again yielded negative cultures and cytology. Eventually a repeat CT-hip 1-month post admission showed new soft tissue lesions in the superficial muscle layers. Biopsies performed returned as intermediate grade angiosarcoma with positive CD31 and ERG stainings. This is the first case study to describe an aggressive metastatic angiosarcoma mimicking a PJI on initial presentation. Angiosarcomas are very rare and presentations may also be highly varied. Diagnosis of angiosarcoma may be made difficult by the absence of clear lesions to biopsy, as in this particular case. A high clinical suspicion of a pathological periprosthetic fracture is needed when diagnosing patients who present atypically for PJIs.
Proceso editorial trilingüe de artículos científicos: desafíos y oportunidades
Authors: Valentim Marta Lígia Pomim , Penna Joana Gentil
Published: February 2025

El proceso editorial trilingüe implica crear, editar y distribuir contenido en tres idiomas diferentes. Este proceso es especialmente relevante en contextos multiculturales o internacionales, donde el público objetivo proviene de diferentes países y, por tanto, habla diferentes idiomas. La gestión del proceso editorial trilingüe requiere una buena coordinación entre los miembros del equipo y debe implicar la colaboración de todos los involucrados: autores, editores, traductores, revisores, normalizadores, etc. Estos desafíos requieren un enfoque estructurado, con una planificación rigurosa, recursos adecuados y profesionales comprometidos, para garantizar que el contenido sea de alta calidad en todos los idiomas involucrados.
Avaliação por pares
Authors: Rivelini-Silva Angélica Cristina , Justulin Andresa Maria , Reis Sandra Gomes de Oliveira
Published: February 2025

O artigo analisa o processo de avaliação por pares na revista Ensino e Tecnologia em Revista (ETR), focando no modelo duplo-cego. A abordagem adotada foi quantitativa descritiva e analisou a participação de 307 avaliadores cadastrados na revista, de 2017 a 2024, explorando a eficiência e os desafios da avaliação, como taxa de resposta dos avaliadores, distribuição de recomendações e prazos de conclusão. O estudo conclui que, apesar do crescimento na produção científica e visibilidade da revista, há necessidade de otimizar o processo de revisão para garantir eficiência e equidade.
Atención integral a la salud de adolescentes y jóvenes desde la perspectiva de profesionales de atención primaria, San Pablo, Brasil
Authors: Ayres José Ricardo de Carvalho Mesquita , Mendes Valéria Monteiro , Almeida Isabella Silva de , Devincenzi Macarena Urrestarazu , Guimarães Jamile Silva , Calazans Gabriela Junqueira , Bianchi Pamela Cristina , Yamashiro Alberto Shodi , Grupo de Pesquisa em Saúde de Jovens e Direitos Humanos
Published: February 2025

La integralidad es un principio recomendado a nivel global para una atención a la salud eficaz, especialmente en el caso de adolescentes y jóvenes, cuyas necesidades asocian aspectos biomédicos con procesos socioculturales de construcción de subjetividad y ejercicio de la ciudadanía. Sin embargo, existen importantes desafíos para su implementación efectiva. Este estudio tiene como objetivo identificar aquellos aspectos del trabajo realizado en unidades básicas de salud del estado de São Paulo, Brasil, que los profesionales consideran como facilitadores u obstáculos para la producción de un cuidado integral a la salud de adolescentes y jóvenes. Se trata de un estudio cualitativo llevado a cabo entre enero y noviembre de 2023, en el que se realizó observación del cotidiano de trabajo y entrevistas semiestructuradas a 73 profesionales de la salud. Se destaca el predominio de acciones descontextualizadas, fragmentadas y prescriptivas, en un contexto de carencias de recursos y de articulaciones intersectoriales. Se sostiene la necesidad de que adolescentes y jóvenes participen como sujetos de derechos en la construcción de acciones y políticas intersectoriales de salud.
Legitimacy of the Azerbaijan Democratic Republic in Late 1918 – Early 1920 and English Intervention in Transcaucasia
Authors: Chshiev T. G. , Savinkina L. A. , Rodionov S. V.
Published: February 2025

Aim. Determining the political and legal impact of British intervention on the formation of the Azerbaijan Democratic Republic..

Methodology. A political and legal comparative analysis of the process of constitutioning the Azerbaijan Democratic Republic was carried out.

Results. The authors have revealed that the Azerbaijan Democratic Republic took place largely under the influence of foreign interventionists, primarily the British military authorities, who were looking for political support in the Transcaucasian region.

Research implications. For the first time in the study of the history of the state and law of Russia, an analysis of the influence of the English intervention on the constitution of anti-communist regimes in Transcaucasia is made on the example of the Azerbaijan Democratic Republic. The materials of this article can be used in the educational process within the framework of the subject “History of State and law”.
The disparity in development across the Volga-Ural region: A fragile semi-periphery
Authors:   Saratov State University, Preobrazhenskiy Yuri V.
Published: February 2025

The issue of regional development in relation to the reproduction of human capital is becoming increasingly urgent every year.
Therefore, it is necessary to analyze the potential for redistributing human resources within meso- and macro-territorial systems. Using the
example of the Volga-Ural macro-region in Russia, the main areas with varying growth potential are considered. Special attention is given to the
semi-peripheral or equilibrium zone. Based on data from 2018 to 2023, we analyze changes in the quality of urban environments and urban
population dynamics in the Volga-Ural region. Using the example of the Saratov region, we show changes in the distribution of cities according to
populationsize. Factors at differentspatial levelsthat influencethe balance between developing, equilibrium, and depressive areas are identified.
The conclusion is drawn about the difficult economic situation of settlements in the equilibrium zone and their exhaustion as a source of human
capital for central cities.
Peculiarities of summer transformation of air masses in the Lower Volga region of stationary arctic anticyclones
Authors:   Saratov State University, Morozova Svetlana V. , Polyanskaya Elena A. ,   Saratov State University, Alimpieva Mariya A. ,   Saratov State University, Petrova Alina A. ,   Saratov State University
Published: February 2025

Introduction. Transformation is understood as a change in the properties of an air mass: its temperature, humidity, and stability.
Transformation changes are especially strong in the summer when cold air from the Arctic basin shifts to the continental regions of Eurasia.
When empirically studying the transformation process, there are difficulties associated with determining its beginning and end. Considering
that transformation processes are highly dependent on geographical and meteorological factors, it is interesting to study the specifics of this
process in the Lower Volga region. Theoretical analysis. The intensity and speed of transformation areconsidered. The magnitude of the increase
in the average daily temperature during the stationary state of the Arctic anticyclone is taken as the intensity of transformation. The speed of
transformationwas estimated by themagnitude of the inter-day temperature variability. Conclusion.The average duration ofstationarity of Arctic anticyclones in the Lower Volga region is five days. During their stationarity, the air mass warms up by 5–8°C, and the intensity of transformation
decreases when shifting from north to south. The maximum transformation speed is on the second day in Saratov and Volgograd, on the third –
in Samara and Astrakhan. In July and August, the highest transformation speed is noted on the fourth day in Samara, on the third – in Saratov,
and on the second – in Volgograd and Astrakhan.
Investigating the Prevalence of Headache and its Influencing Factors in the Intensive Care Unit
Authors: Hossein Aghamiri Seyed , Erfani Ali , Borji Milad
Published: February 2025

Background: Headache may be aggravated by factors such as contracting new diseases, taking medications, or being hospitalized. One of the diseases that is effective in causing pain, especially headaches in patients, is the Covid-19 disease. for this reason, this study was conducted with the aim of the prevalence and factors affecting headache in covid-19 patients admitted to the ICU.
Methods: This study is a part of the registry related to covid-19 patients, and the researchers analyzed the data after obtaining the code of ethics in the research. in this study, the tool that was used included a demographic profile form and a checklist for examining pain and its influencing factors in patients admitted to the ICU.  data analysis was done using SPSS version 16 software and independent t-tests, ANOVA, linear regression and confirmatory statistics.
Results: Result showed 1114 (78.8%) of the patients reported headache and 300 (21.2%) of the patients had no complaints about headache. regarding the type of pain, it was shown that 341(30.6%) had Pressure type, 360(32.3%) had Tightening type, 335(30.1%) had Throbbing type and 78(7%) had Irritability type. Also, in relation to the duration of pain, it was shown that 228(20.5%) had pain less than 1 hour, 171(15.4%) had pain between one hour and 24 hours and 715(64.2%) had pain more than 24 were hours. Also, 178(16%) of the patients had moderate headache and 936(84%) of the patients had severe headache.
Conclusion: Considering the high prevalence of headache in patients with covid-19 hospitalized in the ICU, it is necessary to take necessary intervention measures to reduce the patient's headache.
Examining Leadership Practices To Promote A Positive Research Culture Of Integrity In Higher Education Institutions
Authors: Lacey Seán , Wilkinson Jennifer J.
Published: February 2025

What is new?

While Higher Education Institutions (HEIs) have, in recent years, placed greater emphasis on promoting good research practices, it is yet relatively unknown what leadership approaches are best suited to cultivating a positive culture of research integrity (RI) in HEIs.  This small-scale exploratory descriptive study therefore sought to uncover initial findings from within the European context on practices research leaders found to be most effective in leading positive change in this space.

What was the approach?

The design was constructed using semi-structured interviews with five senior research leaders. Countries that were members of the European Network of Research Integrity Offices (ENRIO), with HEIs that were members of the European Association of Research Management and Administration (EARMA) were used as part of the sample selection process.  With the topic being under-researched and the examination being a small-scale exploratory study, opportunistic and purposive sampling were used to recruit participants.

What is the academic impact?

The overarching leadership style found to promote a positive culture of RI in HEIs was collective, with adaptive and competent boundary spanning characteristics, along with cognisance of the need for continuous professional development.  There was agreement among all participants that change in research culture is occurring, and leaders need to adapt to these changes. RI and open research were seen as integral components to promoting good research practices in HEIs.

What is the wider impact?

There are multiple facets to promoting a culture of RI in HEIs, with excellent examples in the literature on both leadership and good research practices.  However there is little evidence of which leadership styles create the best conditions for driving a positive culture of RI in HEIs.
A infodemia do COVID-19 na Cidade Estrutural (DF)
Authors: Cordeiro Batista Ronnalty , Alves da Cunha Marques Angelica
Published: February 2025

No contexto da pandemia do coronavírus-19, a comunidade foi inundada por uma quantidade significativa de fake news, que divulgam, de maneira manipulada e distorcida, informações já conhecidas e validadas cientificamente. Considerando o fenômeno disruptivo da infodemia do Covid-19 na Cidade Estrutural do DF, a pesquisa objetivou analisar as políticas relacionadas à comunicação, à difusão e à promoção do acesso a informações e conhecimentos técnicos-científicos sobre a pandemia nesta cidade. Respaldada nas relações de bio-poder, propostas por Foucault, desenvolveu-se pela identificação de aspectos da transferência de informações e conhecimentos técnico-científicos com vistas a subsidiar a mitigação dos efeitos da desinformação e minimização das desigualdades existentes em comunidades carentes com baixo nível de desenvolvimento social. Pela exploração e descrição de documentos de arquivo e aplicação de questionários, desenvolveu-se em dois seguimentos: nos centros clínicos de saúde pública da comunidade e junto à comunidade LGBTQIA+. Nos centros, analisou os fluxos informacionais do Estado para os agentes de saúde e, na comunidade, pela entrevista de dez pessoas, como estas são (des)informados. Os resultados sinalizam reflexões e ponderações sobre as ações fundamentais para identificação e reconhecimento da ausência do Estado na comunicação e no acolhimento das desigualdades que atravessam o cenário social, bem como a integração dos fluxos num surto viral e informacional.
Aspectos socioculturais e comportamentais na qualidade de vida no trabalho e as patentes interfaces com a ciência da informação
Authors: Santana Rodrigues Pereira Rosane , Sales dos Santos José Carlos
Published: February 2025

O comportamento informacional humano constitui uma temática emergente na ciência da informação e corresponde ao somatório de ações atinentes à recuperação de conteúdos em fontes e canais de informação. Assim, o comportamento informacional apresenta uma patente aderência à qualidade de vida no trabalho devido a condições que englobam diversos aspectos que interferem na vida dos trabalhadores, que envolve condições e ambientes laborais que interferem no bem-estar físico, psicológico e social dos indivíduos vinculados a ambientes institucionais e organizacionais. Considerando as prerrogativas anunciadas, o artigo procurou apresentar as contribuições da ciência da informação para a promoção da qualidade de vida no trabalho, explorando como os princípios, métodos e práticas dessa disciplina podem ser aplicados para melhorar o ambiente de trabalho e o acesso à informação relevante, visando a satisfação, bem-estar e desenvolvimento pessoal e profissional dos trabalhadores. A partir do anúncio do objetivo geral, os procedimentos metodológicos ampararam-se no método de procedimento monográfico (estudo de caso), nível descritivo, população e amostra da investigação, técnica e instrumento de investigação pautada no elenco de referências selecionadas. Os resultados assinalaram que é possível uma ampliação da visão acerca da qualidade de vida no trabalho vislumbrando as interfaces com a ciência da informação, sobretudo referente ao comportamento informacional. As considerações finais anunciam que a ciência da informação pode lastrear, no que tange ao comportamento informacional, transformações efetivas na qualidade de vida no trabalho.
The ecohydrology of a Japanese knotweed invasion
Authors: Adler-Colvin Julianna , DeGennaro Gabriella , Klos P. Zion
Published: February 2025

Polygonum cuspidatum (Japanese knotweed) is an herbaceous, clonal invasive plant that can create a monodominant stand that outcompetes native species, particularly throughout riparian zones. To better understand how this species is so successful at invading, and why particular locations in riparian settings are more at risk, we investigated a variably invaded riparian valley site in the northeastern United States. We measured spatial variations in hydrologic and soil attributes (soil texture, depth profiles, volumetric water content) in relation to spatial variations in Japanese knotweed abundance (percent coverage). We also investigated how the arrival of this species alters the hydrologic properties of the soil (e.g., infiltration rate) at a fine spatial scale (< 1 m). Across all variables observed, the strongest linear correlation (p < 0.01, r = 0.70) was found to be a positive relationship between mean percent coverage of Japanese knotweed and soils with a higher clay proportion. To understand causation in this relationship, and to better know how knotweed alters the physical environment it invades, we measured soil infiltration rates in the presence and absence of stems (n = 40). We found that knotweed occurrence can create a significant (p = 0.05) decrease in infiltration rate, but only within finer soils. These results may elucidate new possible ecohydrologic feedback mechanisms between Japanese knotweed and soil properties that could promote a higher competitive advantage in finer soils. This new insight, along with other known mechanisms promoting knotweed growth, can help to better identify and prioritize conservation efforts around locations more at risk of a successful invasion.
Establishing of Soil Loss Tolerance Limit and Sediment Yield in Zagros Fold Thrust Belt: A case study in the Kanarwe river basin, Iraq-Iran
Authors: Mohammed Fahmy O. , Mohamed Ahmed Ibraheem , Gart Ibrahim H. , Amin Diary A
Published: February 2025

Soil degradation is a significant cause of topsoil loss; in most mountainous region watersheds, it leads to decreased agriculture productivity and reservoir storage. This study targeted calculating and mapping soil loss and sediment yield in the Lesser Zab watershed located between Iraq and Iran. The Revised Universal Soil Loss Equation (RUSLE) model was used to calculate the soil loss. A Digital Elevation Model of 30m, a Digital Soil map (1:500000), rainfall, and land cover were used to derive parameters. The soil loss rates are 58.1 and 0.1 t ha-1yr-1. The total annual soil loss is 1037289 tonnes, of these 404512, covering 75% of Kanarwe river basin land. Most of these affected lands are in the eastern and middle part, which is below the FAOs standard allowable for tolerable soil erosion. Still, the rest covers 25 % of the basin in the west with a total annual soil loss equal to 632777 tonnes, above FAOs standard. The maximum and minimum sediment yield is 29 and 0.1 tha-1yr-1, respectively. Based on the statistical correlation coefficient, the most effective RUSLE Ahmed MOHAMED parameters on sediment yield from high to low are topography 0.48, soil erodibility 0.38, and crop management 0.38.
La transformation mécanique des bois guyanais
Authors: Sales Christian
Published: February 2025

Les bois guyanais sont généralement de forme régulière, mais leur densité est souvent assez élevée. Cependant, les difficultés rencontrées lors de leur transformation proviennent principalement du risque de fendillement dans certaines essences. Le fendillement se produit en raison de la présence d'une contrainte interne, appelée « contrainte de croissance ».Dans cet article, l'auteur montre les moyens de minimiser ce défaut à un niveau satisfaisant. Il mentionne également ce qu'il faut savoir sur le sciage, le choix du matériel et les différents matériaux de coupe.