bluuebunny/crossref_metadata_2025 huggingface dataset:
From Awareness to Action: Fostering Inclusivity for Students with Disabilities
Authors: Lahmiyed Yousra , Najib Slimani  , Khadija Anasse
Published: July 2024

This study aims to investigate the process of fostering inclusivity for children with autism spectrum disorder (ASD) within educational contexts, with a specific focus on understanding the efficacy of Applied Behavior Analysis (ABA) and Assessment of Basic Language and Learning Skills (ABLLS) programs. It draws from experiences gained through collaboration with professionals and parents at the Princesse Lalla Meryem Pour Enfants Autistes Institute in Tangier. Set within the dynamic landscape of Morocco's disability support and education sector, this research unfolds within the framework of the Princesse Lalla Meryem Pour Enfants Autistes Institute in which ABA and ABLLS programs are used extensively, complemented by individualized support provided by dedicated assistants for each student. Furthermore, cognitive behavioral therapy is integrated into the educational approach. The overarching goal of the organization is to equip children with ASD with the necessary skills to integrate successfully into mainstream educational institutions. By employing a participatory action research methodology, this study engages closely with professionals, parents, and autistic students. Qualitative interviews, observations, and collaborative reflections serve as key methods to understand the nuances and effectiveness of ABA, ABLLS, and cognitive behavioral therapy in fostering inclusivity. Initial findings highlight the pivotal role of individualized support and evidence-based interventions such as ABA, ABLLS, and cognitive behavioral therapy in promoting the inclusion of children with ASD. Insights gleaned from the experiences of both professionals and parents shed light on promising practices and areas for further enhancement in preparing autistic children for successful integration into mainstream educational institutions. This study enriches the existing literature by providing firsthand insights into the practical applications of ABA, ABLLS, and cognitive behavioral therapy within the context of an inclusive educational organization in Morocco. By bridging theory and practice along with incorporating diverse perspectives, the study aims to inform the development of more effective inclusive policies and practices, ultimately contributing to the successful integration of children with ASD into mainstream educational settings.
АНАЛІЗ ДІЯЛЬНОСТІ ІНКЛЮЗИВНО-РЕСУРСНИХ ЦЕНТРІВ В УКРАЇНІ В УМОВАХ ВІЙНИ
Authors: Сушко Павло , Прохоренко Леся
Published: July 2024

У статті обґрунтовано, що в умовах війни в Україні виникли серйозні виклики в системі освіти осіб з особливими освітніми потребами. Інклюзивно-ресурсні центри, які спеціалізуються на підтримці осіб з особливими потребами та інших вразливих груп громадян, відіграють критичну роль у забезпеченні доступу до якісної освіти, ресурсів та підтримки, особливо під час військових дій.
Дослідження роботи інклюзивно-ресурсних центрів в умовах війни в Україні дало змогу виявити потреби цих центрів, виклики, з якими вони зіштовхуються, а також сформувати шляхи покращення їхньої діяльності. Розкрито мету створення таких установ та завдання, які вони покликані вирішувати. З’ясовано наявний стан діяльності мережі інклюзивно-ресурсних центрів в Україні. За даними опитування, виявлено низку проблем в діяльності ІРЦ, зокрема: неузгодженість нормативно-правових актів, які регулюють діяльність ІРЦ; перевантаження наявного ресурсу ІРЦ, зокрема кадрового (брак фахівців; фахівці, які залишилися, виконують роботу, що охоплює всю сферу послуг для населення (іноді це один чи два фахівці); складність у виконанні комплексної оцінки і супровід внутрішньо переміщених дітей з особливими освітніми потребами та підтримку їх батьків (кількість ВПО значно більша, ніж в інших, що впливає на спроможність ІРЦ та часто потребує розширення їх мережі); брак фінансування (розподіл коштів субвенцій та місцевого бюджету між ІРЦ залежить від рішень громади, тому в різних громадах різна фінансова підтримка ІРЦ) тощо. Доведено, що мережа інклюзивно-ресурсних центрів продовжує розвиватися задля доступності послуг, які вони надають дітям і їхнім родинам. Проаналізовано інноваційні сервіси та онлайн-ресурси надання відповідних послуг та наголошено на потребі їх вдосконалення.
У висновку зроблено припущення, що отримані дані дослідження можуть сприяти розробленню політик та програм, спрямованих на підтримку інклюзивності та соціальної справедливості в умовах війни.
ПРОФЕСІЙНА САМОСВІДОМІСТЬ ОРТОПЕДАГОГІВ
Authors: Шульженко Олександр
Published: July 2024

У статті на основі аналізу світових та українських теоретико-методологічних джерел визначено основні погляди відомих наукових шкіл, їх теоретичні засади та переконання в тому, що самосвідомість є необхідним і дієвим компонентом процесу саморозвитку особистості, внутрішнім психологічним механізмом запуску ефективної діяльності; можливістю та психологічним чинником впливу на процеси саморегуляції, довершеною умовою для формування мотивації, самооцінки та якості спілкування, психологічних установок на сприймання та прийняття людей з іншими етнопсихологічними стратегіями, поглядами та поняттями. Зазначено, що мозок людини відіграє основну роботу в забезпеченні чистоти думки, переконань, чутливості, емоційної гармонії та розуміння сутності явищ повсякденного життя.
Представлено розуміння різними авторами свідомості, зокрема самосвідомості дослідниками різних світових наукових шкіл філософського, гуманістичного, біхевіристичного, когнітивного, соціально-когнітивного спрямування, які можуть конкурувати між собою, мати різну методологію, проте їхнє розуміння свідомості дає змогу переосмислювати на методологічному рівні проблему формування самосвідомості тих, хто навчає, виховує, реабілітує, здійснює корекцію і компенсацію осіб із особливими освітніми потребами. Вже в минулому залишилось тоталітарні погляди на вихованців, на ролі і функції педагогів, які виконували завдання формувати змалечку страх, тривогу, паніку, психологічний тиск та негативний вплив на психіку дитини, щоб вона змалечку думала і говорила, як їй це скерують, не маючи власної думки. Це було і завданням фахівців, яким не дозволялося, тобто не було в тренді, робити аналітичні операції, висновки та узагальнення, представляти власну думку, опрацьовувати ту літературу, яка обмежувала їх свідому тенденцію до саморозвитку та самовдосконалення.
У спеціальній освіті обмаль досліджень феномену самосвідомості корекційних педагогів, стосовно ортопедагогів розвідок майже не проводилось. Запропоновано за результатами опитування ортопедагогів новий підхід до визначення параметрів розвитку їх професійної самосвідомості.
Polytypic B cells, monotypic/monoclonal B-cell proliferations, and neoplastic T cells diverge from TET2-/DNMT3A-mutant clonal hematopoiesis in follicular helper T-cell lymphomas
Authors: Lewis Natasha E. , Petrova-Drus Kseniya , Sardana Rohan , Huet Sarah , Gao Qi , Sethi Shenon , Vanderbilt Chad , Xiao Wenbin , Roshal Mikhail , Baik Jeeyeon , Bhurtel Himanshu , Moskowitz Alison J. , Horwitz Steven M. , Dogan Ahmet
Published: July 2024

Not available.
A targeted gene signature stratifying mediastinal gray zone lymphoma into classical HL-like or PMBL-like subtypes
Authors: Gargano Grazia , Vegliante Maria Carmela , Esposito Flavia , Pappagallo Susanna A. , Sabattini Elena , Agostinelli Claudio , Pileri Stefano A. , Tabanelli Valentina , Ponzoni Maurilio , Lorenzi Luisa , Facchetti Fabio , Di Napoli Arianna , Lucioni Marco , Paulli Marco , Leoncini Lorenzo , Lazzi Stefano , Ascani Stefano , Opinto Giuseppina , Zaccaria Gian Maria , Volpe Giacomo , Mondelli Paolo , Bucci Antonella , Selicato Laura , Negri Antonio , Loseto Giacomo , Clemente Felice , Scattone Anna , Zito Alfredo F. , Nassi Luca , Del Buono Nicoletta , Guarini Attilio , Ciavarella Sabino
Published: July 2024

Not available.
Mimicry of inherited red cell disorders: the result of somatic mutations in a clonal myeloid disease
Authors: Lichtman Marshall A. , Jajosky Audrey N.
Published: July 2024

Not available.
Management difficulties in a patient with post-traumatic stress disorder and role of trauma focused cognitive behavior therapy
Authors: Hasan Mohammad , Singha Romendra Kumar , Roy Susmita , Arifuzzaman Md
Published: July 2024

Post-traumatic stress disorder is not uncommon but in practical ground it is really difficult to treat these patients. Multiple treatment options are in hand but psychological treatment is the first recommendation. Initially after the exposure or incident symptoms may be severe. In case of severe agitation, self-destructing behavior, intense psychological distress, extreme sleep disturbances or anger outbursts, pharmacological intervention as early as possible is needed.  Stress coping skills, relaxation therapies, psychological first aid and trauma focused cognitive behavior therapy (CBT) are important to treat the patient and get back full functional state.  Prevention of suicide and self-harm is vital. Risk assessment, presence of hostility and complete personal history guide psychiatrist to take measures. The case described below was a good example resolution by trauma focused CBT. In this case patient had severe symptoms, aggression and self-destructive behavior. By using pharmacological intervention and using all available resources of psychological therapy, patient improved.
Bang J Psychiatry 2023;37(1): 20-22
Exploring mental health needs, coping and suitable service modalities for people affected by coronavirus disease 19
Authors: Tamanna Fairuz Hossain , Anik Asibul Islam , Faruk Md Omar , Jahan Rubina , Mozumder Muhammad Kamruzzaman , Selim Ashique
Published: July 2024

There was a general gap on coronavirus disease (COVID) 19 related mental health concerns and coping data from the peak period of pandemic. With the aim of ensuring evidence informed service delivery, this study explored mental health needs, coping mechanisms and preferred service modalities of the front-line healthcare workers (FLHWs), COVID 19 patients and family members of both patients and FLHWs. Sixty-three participants were included in this cross-sectional study which was conducted at the period from July 2020 to December 2020.  The FLHWs and patients were recruited using purposive sampling from a COVID 19 dedicated hospital in Narayanganj while the family members were selected through the contact detailed shared by the FLHWs and the patients. Three mental health professionals conducted the interviews over the phone using a semi-structured qualitative interview guide. The findings of the study were presented in three broad categories, namely a) concerns around psychosocial health and wellbeing, b) coping with COVID 19 and its impacts and c) preferred modalities for psychosocial service delivery. The results showed that, low mood was most common (68.3%) followed by irritability and anger (65.1%) and concerns about the future (61.9%) among the participants. A very high number of participants (74%) reported an increase in religious activity and faith. As strategies to cope with the pandemic crisis, the participants most commonly reported engagement in entertainment (27%), taking care of relationships (21%) and engagement in spirituality (17%). The most preferred modality of service was self-help materials (49%; online videos, booklets, posters/leaflets) followed by webinars (12%) and online counselling (10%). However, to enable evidence informed service delivery during any severe pandemic such as COVID 19, the mental health needs of FLHWS and their family members must be addressed.
Bang J Psychiatry 2023;37(2):38-45
Subacute sclerosing panencephalitis with disorganized behavior: a case report from psychiatry ward
Authors: Rahman Mahabuba , Syed Sifat E , Morshed Nahid Mahjabin , Chowdhury Hafizur Rahman
Published: July 2024

Subacute sclerosing panencephalitis (SSPE) is a late onset, rare and slowly progressive viral encephalitis with a mandatory fatal outcome. The disease initially presents with myoclonic jerks and seizures, ocular manifestations, cognitive decline and behavioral disturbances.  However, few rare cases of SSPE had been reported with the initial presentation of sole psychiatric symptoms creating a diagnostic dilemma. We hereby reported a case of an 18 years-old male presented with a history of disorganized behavior who was further evaluated as a case of SSPE. The importance of a holistic approach to rule out organic causes before diagnosing a psychiatric disorder had been highlighted in this report.
Bang J Psychiatry 2023;37(2): 49-51
Teachers’ perceptions of Bangladeshi EFL tertiary learners’ writing challenges
Authors: Karim Shah Mohammad Sanaul
Published: July 2024

Writing is one of the most challenging skills for the Bangladeshi EFL tertiary learners. The learners, teachers and educators refer to the difficulty of the learners in writing different types of compositions. Among the types of compositions, paragraphs facilitate a learner to opt for bigger compositions as well as for discreet sentences. This study reports the findings about the paragraph writing problems of the Bangladeshi EFL tertiary level learners. Data were collected through questionnaire and semi-structured interviews. The questionnaires were distributed to 6 teachers of English Language and Literature at International Islamic University Chittagong, Bangladesh and semi structured interviews were conducted with two teachers teaching paragraph writing to the students. Findings from the questionnaires have revealed that the revising stage is very difficult for the learners followed by writing and planning stages. Findings from the semi-structured interviews with the teachers have corroborated the findings of the questionnaire. The findings draw attention to the different types of problems in the writings of paragraphs by the Bangladeshi EFL tertiary learners and provide implications.
IIUC Studies Vol.19, December 2022: 19-52
Development of national health data warehouse frame work for Bangladesh
Authors: Khan Shahidul Islam
Published: July 2024

Data Warehouse (DW) integrates data from two or more sources into a repository for reporting, analysis, and knowledge discovery. This technology can be used in healthcare to develop National Health Data Warehouse (NHDW) that combines patient information from clinics, hospitals, laboratories, diagnostic centers, etc. In this research, we propose a framework for NHDW based on studying different global frameworks and conducting surveys among the potential stakeholders of the framework. Here, patient data will be collected in two phases: physical data collection and data collection over the internet. We did surveys on different healthcare organizations among patients, medical staff, and doctors. The survey questionnaire was divided into four sections: personal information, information privacy and security, performance, and usability to know the requirement of the stakeholders. As healthcare data is very sensitive and can be misused, providing privacy for these patients' information is properly addressed in this framework. The NHDW framework may significantly improve our healthcare services in Bangladesh.
IIUC Studies Vol.19, December 2022: 53-68
A woman empowered with the power of love: A study of Alu in The Swamp Dwellers by Wole Soyinka
Authors: Uddin Md Abu Saleh Nizam
Published: July 2024

The Swamp Dwellers by Wole Soyinka (born, 1934) is mostly discussed for the emphasis it puts on the strong family ties felt by all the characters, presence of the elements of the absurd drama, corruption by the priests and human-nature relationship. But the powerful character Alu is also an area to concentrate on. She is a powerful woman with the power of love. This virtue of love she receives from her instinct, and her African tradition turns her into a powerful woman. Thus empowered, she plays her role in family, society, religion and nature. In the modern world where utmost cruelty looms large everywhere, love-empowered Alu is an example for positive change. Thus, this paper aims at exploring how Alu in The Swamp Dwellers is an empowered woman with love, who simultaneously receives her rights and does her duties in family and society, and nurtures deep feeling for religion and nature, and becomes an example to inspire humanity in a world of human catastrophes.
IIUC Studies Vol.19, December 2022: 69-86
A review of β-caryophyllene oxide for its pharmacological properties supported by in silico findings
Authors: Kamal A T M Mostafa
Published: July 2024

Bicyclic sesquiterpene, β-caryophyllene oxide (BCO) is one of the major components of essential oil derived from aromatic plants.  It is reported to possess several interesting pharmacological prospects. BCO’s ability to suppress a few signaling cascades and down regulating various gene products responsible for cancer development against several cancer cell lines was seen along with some analgesic properties. Besides, its interaction with enzymes responsible for metabolism of the drugs performed in-vitro and in-vivo was found to show diminishing and enhancing effects on the enzymes. All the possible relevant published articles on BCO were collected using some popular search engines such as Google Scholar, Pubmed, ScienceDirect etc.  The molecular docking was carried out with the help of Schrodinger Suites-Maestro 2017-1. In addition, the in-silico findings also provided strong evidence in favor of BCO with the ability to be a prospective therapeutic agent. However, from all the information gathered on this compound and clinical trials, this compound may yield beneficial results novel drug discovery.
IIUC Studies Vol.19, December 2022: 87-120
Dynamical analysis of ant colony's collective decision making to explore food from two different resources
Authors: Iqbal Sayed Allamah
Published: July 2024

A social insect-like Ant lives in a colony. Their collective behavior of food recruitment is a universal character. The mathematical model of the food recruitment of the ant colonies meets different challenges in resolving the nonlinearity due to choosing various food exploration contests between the ants and different environmental parameters. This study possesses several leading parameters to overcome the complexity of the model. Besides, the ants are exploring food sources in diverse trails with the intensity of a chemical substance of pheromone concentration also develops nonlinearity. For generality, this study evaluates two food sources of the ant colony's collective responses concerning environmental conditions without varying the ant's behaviors. The investigation of the ant's food quest in this work concentrates on the dynamical analysis of their food exploration from two different resources described by two ordinary nonlinear differentials equations (ODE). The mean-field model of ODE connected to their dynamical analysis demonstrates that food recruitment varies according to individual variability, supportive communication, and environmental restrictions establishing are connected to the stable or unstable system of the ODE.
IIUC Studies Vol.19, December 2022: 121-138
The effect of COVID-19 public health measures on nationally notifiable diseases in Australia during 2020 and 2021
Authors: Rafferty Anna C , Glynn-Robinson Anna , Thangarajah Dharshi , Polkinghorne Ben
Published: July 2024

The novel coronavirus disease 2019 (COVID-19) pandemic prompted Australia to implement large-scale domestic lockdowns and halted international travel. However, the impact of these measures on national notifiable diseases is yet to been fully examined. In this paper, we expand on a preliminary analysis conducted in 2020, and conducted a retrospective, observational study using nationally notifiable disease surveillance system (NNDSS) data to examine if the changes identified in the first half of 2020 continued in Australia through wide-scale public health measures. We found that there was an overall reduction in most of Australia’s nationally notifiable diseases over the two pandemic years during which wide-scale public health measures remained in operation, particularly for 23 social and imported diseases. We observed an increase in notifications for psittacosis, leptospirosis and legionellosis during these years. The public health measures implemented in 2020 and 2021 (including lockdowns, mask mandates, and increased hand and respiratory hygiene) may have contributed to the observed notification reductions. The outcomes of these measures’ implementation provide insights into broader communicable disease control for mass outbreaks and pandemic responses.
Strategi Sistem Jemput Bola Dalam Meningkatkan Motivasi Menabung Nasabah Pada BMT UGT Nusantara Cabang Kediri
Authors: K. Khairan K. Khairan
Published: July 2024

Abstrak
Strategi merupakan metode yang digunakan dalam mencapai suatu tujuaan. Strategi juga dilakukan oleh Bank Syariah seperti Baitul Maal wa Tamwil dalam mengembangkan lembaga dan menarik nasabah. Salah satu strategi yang dapat dilakukan adalah jemput bola. Strategi jemput bola dilakukan dengan mendatangi nasabah untuk bergabung dan menabung dengan BMT UGT Nusantara Cabang Kediri. Tujuan penelitian ini adalah untuk mengetahui strategi jemput bola dalam meningkatkan motivasi menabung pada BMT UGT Nusantara Cabang Kediri. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pengambilan data observasi dan wawancara. Hasil dari penelitian ini bahwa BMT UGT Nusantara Cabang Kediri menghadirkan sistem tabungan dalam menarik dan menghimpun nasabah. Untuk memotivasi nasabah menabung di BMT UGT Nusantara Cabang Kediri menggunakan sistem jemput bola, yang mana petugas menemui nasabah secara langsung untuk memudahkan nasabah melakukan transaksi.
 
Kata Kunci: Strategi, Jemput Bola, Motivasi, dan Menabung
A városi mesemondás hagyománya
Authors: Domokos Mariann
Published: July 2024

A kultúra átadásának legtriviálisabb módja a szájhagyomány útján történő mesélés, amely nem köthető kizárólag bizonyos korszakokhoz vagy társadalmi rétegekhez. A tanulmány abból indul ki, hogy a modern városi környezetben történő mesemondás és az ilyen környezetben elmesélt történetek (irodalmi mesék, nép- és tündérmesék stb.) szintén részei a magyar elbeszélői hagyománynak. A fiktív elbeszélések előállítása és fogyasztása nemcsak a hagyományos népi kultúrában, hanem a modern populáris kultúrában is jeles társadalmi esemény. Jelen írás e megfontolásokat szem előtt tartva a művészi, városi mesemondás 19. század végi (az 1890-es évektől a második világháborúig) szereplőit, intézményeit, alkalmait és szokásait vizsgálja a korabeli magyar nyomtatott sajtótermékek és levéltári források alapján. A nyilvános mesemondás új, városi fórumait a modern polgárság hívta életre, amely elválaszthatatlanul összekapcsolódott a gyermekirodalom fejlődésével, a gyermekszórakoztatás művészi igényeit pedig a fővárosi értelmiség, budapesti művészek, írók, költők és színészek szervezték. A 19. és a 20. század fordulóján az angolszász országokban a könyvtári intézményekre épülő és a közoktatásnak alárendelt művészi mesemondás nemzetközi trendje alakult ki. Ezeket a könyvtári törekvéseket a hazai szakemberek ugyancsak átvették, de egy másfajta magyar mesemondó mozgalom – amely a színházi, művészi gyermekszórakoztatáson alapult – korábbi és jelentősebb múltra tekint vissza. A magyar gyermekirodalmi kultúra intézményesülésében fontos lépést jelentettek az olyan gyermeklapok, mint például a Pósa Lajos által szerkesztett Az Én Ujságom. Pósa az 1890-es évek elejétől kezdve szervezett mesemondó rendezvényeket, amelyek a lap kiadójának érdekeit, valamint a gyermekirodalom és a szerzők népszerűsítését egyaránt szolgálták. Ezek a rendezvények a következő évtizedekben inspiráló mintát szolgáltattak a gyerekeknek szóló mesemesemondó alkalmak széles körének, amelyekben hatékonyan ötvöződtek a marketing- és a jótékonysági funkciók. A tanulmány az irodalmi gyermeklapok, illetve a Magyar Telefonhírmondó által szervezett mesemondások mellett a Fővárosi Állatkertben tartott különleges, szabadtéri gyermekmesemondó-sorozatot vizsgálja. Emellett arra is felhívja a figyelmet, hogy a magyar színészképzés rendszerébe 1900-tól bekerült a színpadi mesemondás oktatása, amelyben nagy szerepet játszott a színművész Balassa Jenő, aki Basa bácsi néven vált közismert, hivatásos mesemondóvá.
Self-Management Dengan Tingkat Stres Pada Mahasiswa Dalam Menghadapi Ujian Objective Structured Clinical Examination (OSCE)
Authors: Aprilia Hastuti Emma , Widianti Efri , Siagian Indah Mentari , Septriyani Diah
Published: July 2024

Mahasiswa keperawatan sering kali mengalami stres dalam mengikuti kegiatan akademik. Salah satu stresornya adalah ujian Objective Structured Clinical Examination (OSCE). Stres pada mahasiswa keperawatan mengakibatkan dampak yang negatif, maka diperlukan self-management atau pengelolaan diri yang baik. Tujuan penelitian ini untuk mengetahui hubungan self-management dengan tingkat stres pada mahasiswa yang akan menghadapi ujian OSCE. Metode penelitian yang digunakan adalah deskriptif kuantitatif dengan analisis korelasi menggunakan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan total sampling dengan jumlah sampel sebanyak 75 mahasiswa . Kuesioner yang digunakan yaitu kuesioner self-management untuk mengukur tingkat self-management pada mahasiswa dan kuesioner Student-Life Stres Inventory untuk mengukur tingkat stres pada mahasiswa. Data yang diperoleh dianalisis menggunakan uji Spearman rank. Hasil penelitian menunjukan sebagian besar mahasiswa memiliki selfmanagement yang tinggi (37,3%) dan tingkat stres sedang (37,3%). Analisis hubungan self-management dengan tingkat stres dinilai dengan menggunakan p-value, dimana nilai p-valuenya adalah 0,000 (< 0,05) dengan r = - 0.865 . Kesimpulan dari penelitian ini yaitu adanya hubungan yang signifikan antara self-management dengan tingkat stres, arah hubungan diantara kedua variabel adalah negatif dengan tingkat keeratan hubungan sangat kuat. Berdasarkan hasil penelitian ini disarankan kepada mahasiswa pada saat menghadapi ujian OSCE untuk bisa mengontrol tingkat stres dengan mempertahankan self-management yang sudah dimiliki.
Achilles tendon compliance influences tendon loading more than Achilles tendon twist in Achilles tendinopathy: a musculoskeletal modeling approach
Authors: Mylle Ine , Funaro Alessia , Crouzier Marion , Bogaerts Stijn , Vanwanseele Benedicte
Published: July 2024

The Achilles tendon exhibits anatomical variations in subtendon twist among individuals, and its compliance can change due to conditions like Achilles tendinopathy. However, current musculoskeletal models overlook these material and morphological variations. This study aimed to investigate the impact of altering Achilles subtendon insertion points and compliance on the triceps surae muscle forces, and therefore tendon loading, during dynamic exercises in one Achilles tendinopathy patient. First, subtendon insertion points were altered in the musculoskeletal model based on a subject-specific 3D freehand ultrasound model and for three types of subtendon twists: low, medium, and high. Second, tendon compliance was modeled based on experimental values, creating three musculoskeletal models: compliant, mean, and stiff. Results indicated that tendon compliance had a larger effect than tendon twist on triceps surae muscle forces. Altering subtendon insertion points to the three types of twist showed a maximal change of 2.3% in muscle force contribution compared to the no-twist model. During the eccentric rehabilitation exercise—a common exercise choice during rehabilitation—the compliant tendon model showed substantial differences compared to the generic (control) musculoskeletal model, resulting in decreased gastrocnemius medialis (−3.5%) and gastrocnemius lateralis (−3.2%) contributions and increased soleus contribution (+ 6.6%). Our study results highlight the necessity of incorporating tendon compliance in musculoskeletal models to accurately predict triceps surae muscle forces, especially in individuals with increased tendon compliance, such as patients with Achilles tendinopathy. Such findings contribute to more accurate predictions of muscle forces and hence, personalized rehabilitation strategies.
Cancer-associated fibroblasts and prostate cancer stem cells: crosstalk mechanisms and implications for disease progression
Authors: Chen Haoran , Fang Suping , Zhu Xudong , Liu Hao
Published: July 2024

Graphical Abstract

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From waste to wonder: exploring the hypoglycemic and anti-oxidant properties of corn processing by−products
Authors: Yang Xiaoqian , Wang Yuelong , Li Jingfeng , Tai Yuxing , Yang Kunping , Lv Jingwei , Sun Jiaming , Zhang Hui
Published: July 2024

Introduction: The industrial processing of corn (Zeamays L.) generates by-products such as corn silk, straw peels, and straw core, which contribute to adverse environmental impacts. Our study aimed to investigate sustainable approaches for mitigating these effects by evaluating the hypoglycemic potential and mechanisms of ethyl acetate fractions derived from these corn derivatives.

Methods: We employed glucose consumption assays, high glucose stress tests, UPLC-QE-Orbitrap-MS analysis, molecular docking, and simulations to assess their components and efficacy. Antioxidant capacities were evaluated using DPPH, FRAP, ABTS, and •OH scavenging assays.

Results: Notably, the ethyl acetate fraction extracted from straw peels (SPE) exhibited a high concentration of flavonoids and phenolic compounds along with pronounced hypoglycemic activity and antioxidant capacity. SPE significantly enhanced glucose consumption in insulin-resistant HepG2 cells while protecting HUVECs against damage caused by high glucose levels. Molecular docking analyses confirmed the interaction between active compounds and α-glucosidase as well as α-amylase, while molecular dynamic simulations indicated stability at their binding sites.

Discussion: In conclusion, the hypoglycemic and antioxidative properties observed in corn by-products such as straw peels, corn silk, and straw core can be attributed to the inhibition of α-glucosidase and α-amylase activities, coupled with their rich phenolic and flavonoid content. These findings highlight the potential of these by-products for applications in healthcare management and their sustainable utilization, demonstrating significant value in the use of agricultural residues.
A study of cultural representation in Hokkien (Southern Min) textbooks
Authors: Huang Yuannan , Song Haoyan
Published: July 2024

This research employed a framework for analyzing cultural representations within textbooks to focus on the three dimensions of geographical contexts, types of cultures and modes of presentation. A quantitative analysis of Hokkien textbooks from Fujian and Taiwan was conducted. The findings revealed that, on one hand, textbooks from both regions predominantly featured Minnan culture with a marked emphasis on cultural products related to the social life and traditional culture of China. On the other hand, the Fujian textbooks tended to present culture via knowledge blocks, whereas Taiwanese textbooks used cultural discourse for cultural presentations. This distinction emphasizes the pivotal role of language education in perpetuating local cultures and values, as well as the challenges entailed in broadening the cultural scope. The outcomes of this study contribute to minimizing the impact of regional factors in textbook research and provide empirical support for enhancing the quality of Hokkien education and the cultural adaptability of teaching materials.
Collaborative effort: managing Bardet-Biedl syndrome in pediatric patients. Case series and a literature review
Authors: Nowak-Ciołek Maria , Ciołek Michał , Tomaszewska Agnieszka , Hildebrandt Friedhelm , Kitzler Thomas , Deutsch Konstantin , Lemberg Katharina , Shril Shirlee , Szczepańska Maria , Zachurzok Agnieszka
Published: July 2024

Bardet-Biedl Syndrome (BBS) is an autosomal recessive non-motile ciliopathy, caused by mutations in more than twenty genes. Their expression leads to the production of BBSome-building proteins or chaperon-like proteins supporting its structure. The prevalence of the disease is estimated at 1: 140,000 – 160,000 of life births. Its main clinical features are retinal dystrophy, polydactyly, obesity, cognitive impairment, hypogonadism, genitourinary malformations, and kidney disease. BBS is characterized by heterogeneous clinical manifestation and the variable onset of signs and symptoms. We present a case series of eight pediatric patients with BBS (6 boys and 2 girls) observed in one clinical center including two pairs of siblings. The patients’ age varies between 2 to 13 years (average age of diagnosis: 22 months). At presentation kidney disorders were observed in seven patients, polydactyly in six patients’ obesity, and psychomotor development delay in two patients. In two patients with kidney disorders, the genetic tests were ordered at the age of 1 and 6 months due to the presence of symptoms suggesting BBS and having an older sibling with the diagnosis of the syndrome. The mutations in the following genes were confirmed: BBS10, MKKS, BBS7/BBS10, BBS7, BBS9. All described patients developed symptoms related to the urinary system and kidney-function impairment. Other most common symptoms are polydactyly and obesity. In one patient the obesity class 3 was diagnosed with multiple metabolic disorders. In six patients the developmental delay was diagnosed. The retinopathy was observed only in one, the oldest patient. Despite having the same mutations (siblings) or having mutations in the same gene, the phenotypes of the patients are different. We aimed to addresses gaps in understanding BBS by comparing our data and existing literature through a narrative review. This research includes longitudinal data and explores genotype-phenotype correlations of children with BBS. BBS exhibits diverse clinical features and genetic mutations, making diagnosis challenging despite defined criteria. Same mutations can result in different phenotypes. Children with constellations of polydactyly and/or kidney disorders and/or early-onset obesity should be managed towards BBS. Early diagnosis is crucial for effective monitoring and intervention to manage the multisystemic dysfunctions associated with BBS.
Assessment of community-driven drought risk management strategies in pastoral and agro-pastoral district of Bale zones south east Ethiopia
Authors: Abdela Umer
Published: July 2024

Pastoral communities in Ethiopia’s Bale Zone face a constant threat: drought. The Bale lowlands are Particularly vulnerable due to unpredictable rainfall patterns. A 4-year drought cycle had gripped the region, as reported by the pastoralists themselves. Rising temperatures and declining rainfall painted a concerning picture, leading to a cascade of problems: crop failures, food insecurity, outbreaks of diseases, and increased child school dropout rates. This in-depth study aimed to shed light on the impact of drought on these communities and their remarkable capacity to adapt. By bridging the knowledge gap on drought’s influence and local coping mechanisms, the study hoped to inform future interventions. The objectives were to identify the impact of drought on Bale’s pastoral communities and to identify the coping mechanisms employed by these communities. The study utilized a mixed-methods approach to capture both qualitative and quantitative data. Data collection techniques included: Engaging with knowledgeable community leaders provided valuable insights into historical trends, community perceptions, and local decision-making processes, Facilitating group discussions allowed community members to share their experiences, concerns, and coping mechanisms in a collaborative setting and administering standardized surveys to a representative sample of households allowed for the quantification of drought’s impact and the prevalence of various adaptation strategies. The Results shows all study locations experienced drought for four consecutive years (100%), Pastoralists reported rising temperatures and declining rainfall. The drought resulted in, Crop failures, Food insecurity, Livestock deaths, increased human and livestock diseases increased child school dropout rates. The study concluded that despite the challenges, the study revealed a heartening story of resilience. Bale’s pastoral communities have not succumbed to despair. Instead, they have developed a multifaceted approach to cope with drought, including: Utilizing existing water sources and creating communal grazing areas for better water conservation, Splitting herds to reduce grazing pressure, implementing early morning grazing to capitalize on dew, diversifying livestock breeds, and strategically destocking herds before droughts to ensure long-term herd sustainability, Diversifying income through trade, transportation services, and petty trade to reduce dependence on livestock production during droughts. Leveraging the enduring strength of traditional social safety nets (“hirpa,” “dare,” and “hameessa”) for crucial support and assistance during hardships. The study underscores the importance of supporting these existing strategies. Policymakers and NGOs can play a vital role by strengthening social safety nets, promoting the adoption of drought-resistant agricultural practices, investing in research on improved water management techniques and drought-resistant crop varieties.
Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study
Authors: Ren Shijie , Sun Chaodi , Zhai Wenjing , Wei Wenli , Liu Jianping
Published: July 2024

Background

Genome-wide association studies (GWASs) have identified 38 loci associated with ulcerative colitis (UC) susceptibility, but the risk genes and their biological mechanisms remained to be comprehensively elucidated.

Methods

Multi-marker analysis of genomic annotation (MAGMA) software was used to annotate genes on GWAS summary statistics of UC from FinnGen database. Genetic analysis was performed to identify risk genes. Cross-tissue transcriptome-wide association study (TWAS) using the unified test for molecular signatures (UTMOST) was performed to compare GWAS summary statistics with gene expression matrix (from Genotype-Tissue Expression Project) for data integration. Subsequently, we used FUSION software to select key genes from the individual tissues. Additionally, conditional and joint analysis was conducted to improve our understanding on UC. Fine-mapping of causal gene sets (FOCUS) software was employed to accurately locate risk genes. The results of the four genetic analyses (MAGMA, UTMOST, FUSION and FOCUS) were combined to obtain a set of UC risk genes. Finally, Mendelian randomization (MR) analysis and Bayesian colocalization analysis were conducted to determine the causal relationship between the risk genes and UC. To test the robustness of our findings, the same approaches were taken to verify the GWAS data of UC on IEU.

Results

Multiple correction tests screened PIM3 as a risk gene for UC. The results of Bayesian colocalization analysis showed that the posterior probability of hypothesis 4 was 0.997 and 0.954 in the validation dataset. MR was conducted using the inverse variance weighting method and two single nucleotide polymorphisms (SNPs, rs28645887 and rs62231924) were included in the analysis (p < 0.001, 95%CI: 1.45-1.89). In the validation dataset, MR result was p < 0.001, 95%CI: 1.19-1.72, indicating a clear causal relationship between PIM3 and UC.

Conclusion

Our study validated PIM3 as a key risk gene for UC and its expression level may be related to the risk of UC, providing a novel reference for further improving the current understanding on the genetic structure of UC.
Genome-wide identification and expression analysis of EPF/EPFL gene family in Populus trichocarpa
Authors: Liu Sha , Chen Ting , Li Xin , Cui Junjun , Tian Yinshuai
Published: July 2024

The Epidermal Patterning Factor/EPF-like (EPF/EPFL) family encodes a specific type of secreted protein in plants and plays an important role in plant growth and development, especially in the process of morphogenesis. To investigate the characteristics of EPF/EPFL gene family members and their regulatory functions in stomatal development of Populus trichocarpa, a total of 15 EPF/EPFL family genes were identified. Then the gene structure, chromosome location, phylogenetic relationship, protein conserved domain and gene expression profile were analyzed. According to phylogenetic analysis, PtEPF/EPFL can be classified into four groups. The gene structure and protein conservation motifs within the EPF family indicate the high conservation of the PtEPF/EPFL sequence. The promoter region of PtEPF/EPFL was found to contain cis-elements in response to stress and plant hormones. In addition, RT-qPCR results indicated that the PtEPF/EPFL have a differentially expressed in different tissues. Under drought stress treatment, a substantial upregulation was observed in the majority of PtEPF/EPFL members, suggesting their potential involvement in drought response. These results provide a theoretical basis for future exploration of the characteristics and functions of more PtEPF/EPFL genes.
Forecasting storm tides during strong typhoons using artificial intelligence and a physical model
Authors: Wang Yulin , Liu Jingui , Xie Lingling , Zhang Tianyu , Wang Lei
Published: July 2024

The combination of typhoon-induced storm surges and astronomical tides can result in extreme seawater levels and disastrous effects on coastal socioeconomic systems. The construction of an appropriate wind field has consistently been a challenge in storm tide forecasting and disaster warning. In this study, we optimized a nonlinear regression formula based on the C15 model to determine the maximum wind radius. The simulation based on the improvement showed good accuracy for storm tides during super typhoon Mangkhut (WP262018), Saola (WP092023), and severe typhoon Hato (WP152017). The correlation coefficients were in the 0.94–0.98 range, and the peak bias was less than 5cm. The trough errors were significantly reduced compared to other wind fields. Owing to the importance and lack of the maximum wind radius (Rmax), we attempted to predict Rmax using an LSTM (Long Short-Term Memory) neural network for forecasting storm tides during strong typhoons. Constrained LSTM showed good performance in hours 6–48, and effectively enhanced the forecasting capability of storm tides during strong typhoons. The workflows and methods used herein have broad applications in improving the forecasting accuracy of strong typhoon-induced storm tides.
Effect of early administration of dexamethasone in patients with COVID-19 pneumonia without acute hypoxemic respiratory failure and risk of development of acute respiratory distress syndrome: EARLY-DEX COVID-19 trial
Authors: Franco-Moreno Anabel , Acedo-Gutiérrez María Soledad , Casado-Suela Miguel Ángel , Labrador-San Martín Nicolás , de Carranza-López María , Ibáñez-Estéllez Fátima , Hernández-Blanco Clara , Jiménez-Torres José , Vallejo-Maroto Ignacio , Romero-Pareja Rodolfo , Peña-Lillo Gabriela , Escobar-Rodríguez Ismael , Torres-Macho Juan ,   EARLY-DEX COVID-19 Research Group
Published: July 2024

Introduction and objectives

Corticosteroids are among the drugs demonstrating a mortality benefit for coronavirus disease 2019 (COVID-19). The RECOVERY trial highlighted that dexamethasone reduced 28-day mortality for hospitalized COVID-19 patients requiring either supplemental oxygen or mechanical ventilation. It is noted that approximately 30% of COVID-19 patients, initially presenting with mild symptoms, will advance to acute respiratory distress syndrome (ARDS), especially those with detectable laboratory markers of inflammation indicative of disease progression. Our research aimed to explore the efficacy of dexamethasone in preventing the progression to ARDS in patients hospitalized with COVID-19 pneumonia who do not yet require additional oxygen but are at high risk of developing ARDS, potentially leading to a reduction in morbimortality.

Methods

In this multicenter, randomized, controlled trial, we evaluated the impact of dexamethasone on adult patients diagnosed with COVID-19 pneumonia who did not need supplementary oxygen at admission but were identified as having risk factors for ARDS. The risk of ARDS was determined based on specific criteria: elevated lactate dehydrogenase levels over 245 U/L, C-reactive protein levels exceeding 100 mg/L, and a lymphocyte count below 0.80 × 109/L. Participants were randomly allocated to either receive dexamethasone or the standard care. The primary endpoints included the incidence of moderate or severe ARDS and all-cause mortality within 30 days post-enrollment.

Results

One hundred twenty-six patients were randomized. Among them, 41 were female (30.8%), with a mean age of 48.8 ± 14.4 years. Ten patients in the dexamethasone group (17.2%) and ten patients in the control group (14.7%) developed moderate ARDS with no significant differences. Mechanical ventilation was required in six patients (4.7%), with four in the treatment group and two in the control group. There were no deaths during hospitalization or during follow-up. An intermediate analysis for futility showed some differences between the control and treatment groups (Z = 0.0284). However, these findings were within the margins close to the region where the null hypothesis would not be rejected.

Conclusion

In patients with COVID-19 pneumonia without oxygen needs but at risk of progressing to severe disease, early dexamethasone administration did not lead to a decrease in ARDS development.

Clinical trial registration

ClinicalTrials.gov, identifier NCT04836780.
The role of cattle manure-driven polysaccharide precursors in humus formation during composting of spent mushroom substrate
Authors: Yang Fengjun , Wang Mengmeng , Zhao Liqin , Fan Bowen , Sun Ning , Liu Juncai , Sun Xinying , Dong Ziming
Published: July 2024

The study examined the impact of adding cattle manure to the composting process of Agaricus bisporus mushroom substrate on compost humification. A control group CK comprised entirely of Agaricus bisporus mushroom substrate, while the experimental group CD (70 percent Agaricus bisporus mushroom substrate and 30 percent cattle manure) comprised the two composting treatments that were established. The study determined that the addition of cow dung has promoted the formation of humus components. Particularly, humic substance (HS-C) and humic acid (HA) increased by 41.3 and 74.7%, respectively, and the ratio of humic acid to fulvic acid (HA/FA) also increased by 2.78. It showed that the addition of cow dung accelerated the synthesis and decomposition of precursors, such as polysaccharides, polyphenols, and reducing sugars. Thereby promoting the formation of humic acid. Network analysis revealed that adding cow dung promoted microbial interactions increased the complexity and stability of the bacterial and fungal symbiotic network, enhanced cooperation and reciprocity among microbes, and assisted in transforming fulvic acid (FA) components. Structural equation modeling (SEM) is a multivariate data analysis method for analyzing complex relationships among constructs and core indicators. SEM illustrated that introducing cattle manure into the composting process resulted in alterations to the correlation between physicochemical parameters and the microbial community, in addition to humus formation. Polysaccharides are the primary precursors for polymerization to form HA, which is an essential prerequisite for the conversion of fulvic acid to humic acid. Additionally, microbes affected the formation of humus, with bacteria substantially more influential than fungi. These findings provide new ideas for regulating the degree of humification in the composting process and have important practical implications for optimizing mushroom cultivation and composting techniques today.