bluuebunny/crossref_metadata_2025 huggingface dataset:
Examen de los niveles de estrés de las mujeres según las etapas de cambio de comportamiento del ejercicio y el estado de autoestima
Authors: Unlu Cisem , Aksu Aykut , Imamoglu Osman , Erdogdu Murat , Karacabey Kursat
Published: February 2022

El objetivo de este estudio es examinar los niveles de estrés de las mujeres sedentarias según las etapas del cambio de comportamiento del ejercicio y el estado de sentirse ellas mismas.  Se incluyeron en el estudio cuatrocientas sesenta mujeres sedentarias que completaron las encuestas en Samsun. Se aplicó una encuesta sobre el nivel de estrés percibido y el cambio en el comportamiento del ejercicio. El estado de salud de las mujeres sedentarias se encontró con un 20,12% muy bueno, un 43,13% bueno, un 24,08% promedio y un 12,57% malo. Se encontró que los puntos de estrés de las mujeres sedentarias eran 29,92 puntos para las que tenían buena salud y 36,72 puntos para las que tenían mala salud. Se encontró también que los puntajes de estrés de los participantes en la actividad física regular durante los últimos 6 meses y 3 años eran más bajos que los que no participaron (p <0,05). Mientras que los niveles de estrés percibidos por las mujeres sedentarias según las etapas de cambio de comportamiento del ejercicio eran altos antes de la tendencia, fueron bajos durante la etapa de mantenimiento del ejercicio. Para reducir el nivel de estrés percibido de las mujeres sedentarias, se recomienda que estén en la fase de mantenimiento de sus conductas de ejercicio.
Actitud y disposición: dos elementos clave para la investigación
Authors: Rocha Nelly , Calcina Carmen , Sucari Wilson , Esteves Angela , Lujano Yolanda
Published: February 2022

El objetivo de este estudio consistió en determinar la asociación entre actitud hacia la investigación y disposición para la realización de tesis en estudiantes de Enfermería de la Universidad Nacional del Altiplano, Perú. El enfoque fue cuantitativo y el diseño, descriptivo-correlacional, con muestreo probabilístico estratificado, constituido por 211 estudiantes. Para ello, se emplearon dos cuestionarios establecidos en escala de Likert. Los datos fueron procesados con SPSS v. 25. Los resultados muestran que el 65.4% de participantes posee buena actitud, alcanzando las puntuaciones más altas en la “importancia del trabajo en equipo” y el “conocimiento de un segundo idioma”, y el puntaje más bajo en “la falta de economía es un obstáculo para realizar investigación.”  Referente a la disposición, el 70.6% califica como buena, destacando que “hacer una tesis abre espacios para estudios de posgrado en el exterior”, pero “la falta de tiempo es una limitante para la investigación”. Considerando la significancia asintótica de 0,021 en la prueba de hipótesis mediante el estadígrafo ji cuadrado, se concluye que existe asociación entre actitud hacia la investigación y disposición para realizar tesis.
Osa patients vs laryngopharyngeal reflux disease: Non-invasive evaluation with NBI and pepsin detection in tears
Authors: Pace Annalisa , Rossetti Valeria , Milani Alessandro , Iannella Giannicola , Cocuzza Salvatore , Maniaci Antonino , Fegatelli Danilo Alunni , Vestri Annarita , Greco Antonio , De Vincentiis Marco , Giovannetti Francesca , Plateroti Rocco , Magliulo Giuseppe
Published: February 2022

Obstructive sleep apnoea (OSA) and laryngopharyngeal reflux disease (LPR) are two common diseases that lower patients' quality of life. OSA is defined by cyclic events of airflow obstruction that occur during sleep, while LPR is characterized by upper airway inflammatory signs and symptoms due to the return of gastroduodenal gaseous and liquid elements. pH-metry is the gold standard in LPR diagnosis, but considering its invasiveness among other negative traits, questionnaires that catalog symptoms and signs of the disease such as Reflux Symptoms Index (RSI) and Reflux Finding Score (RFS) are preferred. Moreover, LPR can be evaluated by testing the presence of pepsin in tears, and Narrow Band Imaging (NBI) has been introduced for the early diagnosis of larynx oncological disease. This paper aims to test whether LPR is more frequent in OSA patients than in control ones, performing a non-invasive protocol composed of RSI, RFS test (with light vs. NBI techniques), followed by pepsin detection in tears. 68 LPR patients were enrolled in the study (45 with OSA and 23 without OSA). A strong linear relationship between Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) was found, and patients who presented pepsin in tears had higher values of AHI and ODI in comparison to patients without it. Pathological RFS and NBI showed higher values of AHI and ODI in comparison to the control group. Furthermore, pathological RSI showed higher values of AHI and ODI in comparison to the control group. In conclusion, this diagnostic combined non-invasive protocol may be a good method to perform an early diagnosis of LPR.
Comparison of the vitality tests used in the dental clinical practice and histological analysis of the dental pulp
Authors: Tenyi Ana , Nemeth Lidija , Golež Aljaž , Cankar Ksenija , Milutinović Aleksandra
Published: February 2022

In dentistry, indirect diagnostic methods such as electrical sensibility testing and pulse oximetry are used to assess the status of the pulp. Our study aimed to determine the correlation between hemoglobin oxygen saturation and vascular volume density (Vvasc). We also wanted to examine an electrical sensibility test and the volume density of myelinated nerve fibers (Vnerv). Twenty-six intact permanent premolars were included in the study. For histological analysis, the pulp tissue was stained with hematoxylin-eosin and immunohistochemically for von Willebrand factor and S100 to detect blood vessels and myelinated nerve fibers, respectively. The stereological analysis was used to determine the Vvasc and Vnerv. Statistical analysis was done using the Pearson correlation test and Welch’s ANOVA test. Histological analysis showed that the pulp tissue was strongly vascularized and innervated. A significant positive correlation was found between Vvasc and hemoglobin oxygen saturation levels (p=0.030). A significant negative correlation was found between Vnerv and the lowest electrical voltage that patient felt (p=0.033). According to the maturity of the dental apex, teeth were divided into a group with open (N=6, OA group) and closed apex (N=20, CA group). We found that pulps in the CA group had higher Vnerv than the OA group (p=0.037). In contrast, there were no significant differences in Vvasc of the pulp tissue (p=0.059), oxygen saturation (p=0.907), or electrical voltage (p=0.113) between both groups. We can conclude that the measurement of pulse oximetry and electrical sensibility test reflect the morphology of healthy pulp tissue independently of the maturity of the dental apex.
Dinamik yükler altında katlanır kanatçık mekanizmasının açılma davranışının deneysel ve nümerik incelenmesi
Authors: AVCI Murat , TAGA Özer , KELEŞ Ömer
Published: February 2022

Bu çalışmada, katlanır kanatçık mekanizmasının çalışması sırasında oluşan sürtünme ve sönüm değerleri deneysel çalışmalara göre elde edilmiştir. Sürtünme için literatürde tavsiye edilen değerler olmasına rağmen, sönüm sistemden sisteme değişen bir olgudur ve test verileri ile elde edilmesi gereklidir. Bu çalışmada öncelikle oluşturulan test düzeneği üzerinde belirli kapalı hacim tahrik basıncı ile mekanizma çalıştırılmıştır ve sistemde gerçekleşen tahrik basıncı ölçülmüştür. Hızlı kamera sistemi ile de mekanizmanın açılması sırasındaki dinamik davranışı kaydedilmiştir. Adams MBD (çoklu cisim dinamiği) ile mekanizma modeli oluşturulmuş ve testten elde edilen tahrik basınç verisi modele girdi olarak tanımlanmıştır. Adams DOE (test tasarımı) yardımı ile sürtünme ve sönüm için belirli aralıklar tanımlanmış, tanımlanan sürtünme ve sönüm aralıklarında ardı ardına birden çok analiz koşturularak mekanizmanın toplam açılma süresi ve açılırken gerçekleştirdiği dinamik davranışlar elde edilmiştir. Elde edilen bu numerik sonuçlardan Test-C ile korelasyonu en yüksek olan modele göre sürtünme ve sönüm değerleri elde edilmiştir. Aynı mekanizma belirlenen sürtünme ve sönüm değerleriyle farklı tahrik basınçları için test edilmiş ve sonuçlar nümerik modellerle kıyaslanmıştır. Sonunda bu yöntemle belirlenen sürtünme ve sönüm değerlerinin ileride yapılacak gaz tahrikli mekanizmaların numerik analizlerinde kullanılabileceğine karar verilmiştir.
Nucleofection of hPSCs v1
Authors: Li Hanqin
Published: February 2022

This protocol describes the standard procedure for the delivery of plasmids, mRNA or ribonucleoprotein (RNP) into human pluripotent stem cells (hPSCs) using nucleofection. General notes Throughout this protocol, the term hPSC is used to collectively refer to both hiPSCs and hESCs. All described procedures have been tested and work equally well for hiPSCs and hESCs.
Measuring urea concentrations in water samples v1
Authors: Waldbauer Jacob , Amy Zimmerman Amy
Published: February 2022

Colorimetric assay for direct (vs. enzymatic) measurement of urea to a detection limit of 0.4 µM concentration. The reaction of urea with diacetylmonoxime (DAM) to form a colored product is enhanced by addition of thiosemicarbazide (TSC). The original direct method was adapted for use with a single mixed reagent and incubation at room temperature (vs. the “high temperature direct method” that incubates at 85ºC for 30 minutes). NOTE: This protocol is written for measurement in 24-well plates.
Multisite Gateway Calculations: Excel spreadsheet v1
Authors: Mosimann Christian
Published: February 2022

Multisite Gateway cloning provides a modular tool to assemble plasmid vectors suitable for numerous applications. The assembly of Multisite Gateway plasmids requires the correct ratios of three entry vectors and the destination backbone to favor correct recombination by Gateway LR Clonase II Plus. While simple, the calculation of recombination mixes is a reoccurring task when using Multisite Gateway that benefits from automation and proper documentation. This protocol provides a simple Excel-based spreadsheet to simplify the involved calculations based on providing individual vector lengths and working stock concentrations. Using this Multisite Gateway calculations spreadsheet supports correct reaction mix assembly, scaling of cloning reactions, cloning documentation, and troubleshooting.
[RETRACTED] Keto Extreme South Africa v1
Authors: Extreme South Africa Keto
Published: February 2022

[RETRACTED]

Keto Extreme South Africa
Protocol for Exo-CIP™ Rapid PCR Cleanup (#E1050) v2
Authors: England Biolabs New
Published: February 2022

Exo-CIP™ Rapid PCR Cleanup Kit Rapidly degrade residual PCR primers and dephosphorylate excess dNTPs after amplification Reaction complete in 4 minutes Thermolabile formulation can be heat inactivated in 1 minute at 80°C PCR product can be used directly in downstream applications Compatible with commonly-used reaction buffers
solución al problema de las drogas ilícitas en la construcción de paz. Desafíos en la implementación del Programa Nacional Integral de Sustitución de Cultivos Ilícitos (PNIS) en Colombia
Authors: Mantilla Silvia , Sastoque Tania Gisel , Quintero Sofía
Published: February 2022

Este artículo presenta un análisis de la formulación e implementación de los programas y políticas del posacuerdo en Colombia respecto al punto 4 del Acuerdo de paz entre el Gobierno de Colombia y las FARC-EP sobre la Solución al problema de las drogas ilícitas a partir del enfoque crítico de construcción de paz —paz liberal versus paz híbrida—. El análisis se desarrolla a partir de una metodología de enfoque cualitativo, un balance de políticas públicas y una sistematización de datos contrastados a partir de los enfoques teóricos. Se sostiene que, a pesar de la noción híbrida y contextualizada que evidencia el Acuerdo frente al desafío de los cultivos ilícitos, en la práctica la formulación e implementación del PNIS responde a la noción monoontológica y tecnocrática de la paz (neo)liberal. Esto se ha expresado en el corto plazo (2016-2020) a través de dos variables: a) la focalización del gasto como solución al problema de los cultivos y b) la participación comunitaria y legitimadora de la visión liberal en la implementación de los acuerdos colectivos y territoriales.
Democracia, equilibrio informativo y pedagogía electoral. Análisis de la función orientadora del periódico regional La Patria en las elecciones locales de octubre de 2019
Authors: Alguero Montaño Miguel Orlando
Published: February 2022

En los últimos años se ha observado que en las regiones de Colombia hay dificultad para acceder a los medios de comunicación, déficit de información y escasa formación democrática, y el cubrimiento periodístico se limita al registro noticioso de los hechos. Bajo este contexto, cobra importancia el papel de los medios regionales en el fortalecimiento de la democracia y de la libertad de expresión en las elecciones locales para elegir gobernadores, alcaldes, concejales, diputados y ediles. A partir de la agenda setting, el framing y la teoría funcionalista de la comunicación, esta investigación busca determinar si el periódico regional La Patria de Manizales, Caldas, cumplió su función orientadora en las elecciones locales de octubre de 2019. La metodología se basó en el enfoque cualitativo, se realizó un análisis de contenido de las publicaciones del diario, se aplicó una encuesta a lectores y suscriptores. Según los hallazgos, se concluyó que sí hubo pedagogía electoral por parte del periódico, el cual publicó contenidos con función orientadora, pero predominó más el enfoque logístico que el programático. Hubo elementos para que los lectores votaran de manera informada y se estableció una agenda periodística que priorizó el equilibrio informativo para que los candidatos tuvieran igual presencia en la información.
In vitro antiviral activity against SARS-CoV-2 of plant extracts used in Colombian traditional medicine
Authors: Flórez-Álvarez Lizdany , Martínez-Moreno Jahnnyer , Zapata-Cardona María I. , Galeano Elkin , Alzate-Guarin Fernando , Zapata Wildeman
Published: February 2022

Background: Coronavirus infectious disease 2019 (COVID-19) caused by the infection with the new coronavirus SARS-CoV-2 has affected the life and health of more than 222 million people. In the absence of any specific pharmacological treatment, the need to find new therapeutic alternatives is clear. Medicinal plants are widely used worldwide to treat different conditions, including COVID-19; however, in most cases, there are no specific studies to evaluate the efficacy of these treatments. Objective: This article evaluates the antiviral effect of six plant extracts used by indigenous and afro Colombian people against SARS-CoV-2 in vitro. Methods: The antiviral effect of six extracts prepared from plants used in Colombian traditional medicine was evaluated against SARS-CoV-2 through a pre-post treatment strategy on the Vero E6 cell line. Once cytotoxicity was established through an MTT assay, the antiviral effect of the extracts was calculated based on the reduction in the viral titer determined by plaque assay. Results: Gliricidia sepium inhibited SARS-CoV-2 in a 75.6%, 56.8%, 62.5% and 40.0% at 10 mg/mL, 8 mg/mL, 6 mg/mL, and 2 mg/mL, respectively, while P. tuberculatum treatment reduced viral titer in 33.3% at 6 mg/mL after 48h. Conclusion: G. sepium and P. tuberculatum extracts exhibit antiviral activity against SARS-CoV-2 in vitro.
Chemoimmunotherapy in urothelial cancer: concurrent or sequential?
Authors: Pavlov A. Yu. , Dzidzariya A. G. , Gafanov R. A. , Khalil' I. I. , Vashurin A. R.
Published: February 2022

Advances in immuno-oncology in the treatment of metastatic urothelial cancer have overturned current perspectives on the treatment of this type of tumor. The success of using Immune checkpoint inhibitors in metastatic urothelial cancer raised the question of effectiveness of immunotherapy added to standard first-line chemotherapy. This review presents data coming from actual studies examining chemotherapy and immunotherapy in urothelial cancer, or a combination of these methods. Ongoing and planned clinical studies should help identify the optimal sequencing, feasibility of combination, and best duration of treatment with checkpoint inhibitors in urothelial cancer.
Metachronous development of breast and prostate cancer (case report)
Authors: Gordiev M. G. , Druzhkov M. O. , Dulesova A. Yu. , Nikitin A. G. , Ulyanin M. Yu. , Platonova E. V. , Brovkina O. I.
Published: February 2022

The formation of primary multiple malignant neoplasms, such as breast cancer and prostate cancer, in one patient is a rather rare combination. Treatment and diagnostic strategies in such cases require a multidisciplinary approach. Currently, there are no approved recommendations for the management of patients with a combination of these diseases. This manuscript presents a clinical case of diagnosis and treatment of breast and prostate cancer in one patient.
BRCA associated prostate cancer. BRCA heredity of one family
Authors: Izmailov A. A. , Sultanbaev A. V. , Menshikov K. V. , Nasretdinov A. F. , Musin Sh. I. , Ayupov R. T. , Sultanbaeva N. I. , Ibragimov B. A. , Khasiev A. R.
Published: February 2022

In western European countries prostate cancer is one of the most common malignant disease among male population. Due to innovations in molecular genetics research technology over recent years genetic features of etiology and pathogenesis of prostate cancer have been discovered and this helped to distinguish people with high risk of prostate cancer development. Hereditary forms of malignant tumors occupy a special position due to association with mutations in BRCA1/2 gene in a group of patients with prostate cancer. The most important part of examination of patients with malignant diseases is medico-genetic counseling. It helps to reveal the hereditary of the disease. The detection of germinal mutations in BRCA1/2 gene helps to personify diagnostic measures for primary prophylaxis and treatment of prostate cancer.

Here is a case of one patient with hereditary feature of prostate cancer with a mutation in BRCA1 gene. It is important to note that revealing mutations in BRSA gene helps to early diagnose malignant neoplasms. Screening measures to reveal germinal mutations in healthy population can improve early detection of such malignant diseases as breast cancer, prostate cancer and other malignant neoplasms.
Comparison of perioperative and short-term functional outcomes of laparoscopic partial nephrectomy in patients with cT1aN0M0 and cT1b-T2aN0M0 tumors
Authors: Kotov S. V. , Nemenov A. A. , Yusufov A. G. , Guspanov R. I. , Pulbere S. A. , Prostomolotov A. O.
Published: February 2022

Background. Since partial nephrectomy and radical nephrectomy demonstrate comparable oncological safety, nephronsparing surgery is the method of choice in patients with stage T1-T2aN0M0 renal cell carcinoma.

Objective: to compare the main perioperative parameters and short-term functional outcomes of treatment for localized stage cT1aN0M0 and cT1b-T2aN0M0 renal cell carcinoma.

Materials and methods. A total of 148 laparoscopic partial nephrectomies were performed at N.I. Pirogov City Clinical Hospital No. 1, N.I. Pirogov Russian National Research Medical University between 2016 and 2020. Study participants were divided into two groups. Group 1 included patients with stage cT1aN0M0 tumors (n = 89; 60.1 %), whereas group 2 comprised patients with stage T1b-T2aN0M0 tumors (n = 59; 39.9 %).

Results. The duration of surgery was 120 min (range: 90-150 min) in group 1 and 145 min (range: 120-170 min) in group 2 (p = 0.001). The median time of warm ischemia was 13 min (range: 7-17) and 15 min (range: 12-19 min) in groups 1 and 2, respectively (p = 0.002). Seven individuals from group 1 (7.9 %) and 12 individuals from group 2 (22.3 %) had their pelvicalyceal system lanced. The median glomerular filtration rate calculated using the MDRD (Modification of Diet in Renal Disease) formula was 56.4 mL/min/1.73 m2 in group 1 and 54.3 mL/min/1.73 m2 in group 2 (p = 0.252). Three patients in group 1 (3.4 %) had positive resection margin. The median follow-up time was 21 months.

Conclusion. Nephron-sparing surgeries are an acceptable option for patients with stage cT1b-T2aN0M0 tumors in terms of their oncological and functional safety. Tumors exceeding 4 cm were associated with an increased risk of disease progression.
Prognostic significance of PTEN, RB1 and BRCA2 gene loss in patients with localized and locally advanced prostate cancer
Authors: Arnautov A. V. , Musaelyan A. A. , Nazarov V. D. , Lapin S. V. , Reva S. A. , Petrov S. B. , Orlov S. V.
Published: February 2022

Background. Prostate cancer is the most common malignant condition among oncological diseases of the genitourinary tract, which occupies the second place in male mortality from malignant neoplasms. At the same time, population of patients with prostate cancer is heterogeneous: in some patients, the disease does not require active treatment, while in others it progresses rapidly with the formation of metastatic castration-resistant prostate cancer. Therefore, the search for new predictive markers remains relevant.

Objective. Analysis of the prognostic significance of the loss of heterozygosity of PTEN, RB1, TP53, BRCA1 and BRCA2 genes in patients with localized and locally advanced prostate cancer.

Materials and methods. The study included 52 patients with prostate cancer, 31 (59.6 %) of whom had a localized form (T1-2N0M0), and 21 (40.4 %) - locally advanced (T3a-bN0/1M0). All patients underwent radical prostatectomy, followed by genotyping of postoperative and biopsy specimens to determine genetic alterations in the studied genes. Detection of deletions in the studied genes was carried out using the method of multiplex ligation-dependent probe amplification.

Results. In 13 (25.0 %) patients in the postoperative specimen was detected deletion of PTEN gene, in 6 (11.5 %) - deletion of RB1 gene, and in 1 (1.9 %) - deletion of BRCA2 gene. At the same time, patients with loss of PTEN heterozygosity were more likely to have perineural invasion (p = 0.01) and lymph node involvement (p = 0.0003). Deletion of RB1 gene is associated with more frequent detection of high-grade tumors (p = 0.013), cribriform growth component (p = 0.002), and invasion of the periprostatic tissue (p = 0.005).

Conclusion. Detection of loss of heterozygosity of PTEN and RB1 genes is a promising tool for clarifying the prognosis of the disease, which in the future will allow more accurately stratify patients into risk groups for biochemical relapse.
FEATURES OF NUMERAL EXPLICATION OF A QUANTITATIVE FEATURE IN UKRAINIAN LANGUAGE
Authors:   Academician Stepan Demyanchuk International University of Economics and Humanities, MEDYNSKA Natalia
Published: February 2022

The article investigates the part-of-speech class of Numerals as class of attributive words in semantic and grammaticaldimensions in Ukrainian. The peculiarities of the explication of a static feature by Numerals with a quantitative-substantivemeaning in Ukrainian language are clarified.The purpose of the article is to clarify the originality of the functions of numerals as expressions of quantitativesubjectrelations in Ukrainian. Realization of the set purpose provides the decision of such problems, in particular: 1) to find out functions of the Numeral as an attributive word; 2) outline the parameters of Ukrainian Numerals in a staticfeature expression; 3) determine the features of the use of the Numeral in the functionally secondary formal-syntacticposition of the compound nominal predicate.Scientific novelty. The article defines the status of the Numeral as an attributive word in the hierarchy of part-ofspeechclasses – expressions of a static feature in Ukrainian language. As an attributive word, the Numeral functionsin the adnominal position, ie as an expression of quantitative-subject relations (quantitative function), but its static signdiffers from the adjective: it gives a quantitative description of someone or something. The attributive function inherentin the agreed Attribute is performed by Numerals in all indirect cases, except for the accusative. In its second nominativefunction – numerative – the Numeral is likened to a Noun and acquires the meanings of its morphological categories.In conclusion, the article emphasizes that the Ukrainian Numeral, being in the peripheral positions of a sentenceand transmitting, respectively, a static feature with a quantitative-substantive meaning, is the carrier of the secondaryfunction of attributive words. In addition to the genetically primary adjectival position, in which the Numeral determinesthe quantitative trait of someone or something, it is used in the functionally secondary formal-syntactic positionof a compound nominal predicate with the main numeral part, into which it falls through verb conjunctions elements. Sucha predicate is a formal-grammatical representative of a predicate of quantity (quantitative state), for which one valenceposition is typical – the subject of a quantitative sign.
Surgical Treatment of Children with Hip Dislocation in Amyoplasia-Type Arthrogryposis: A Rational Approach to Treatment Selection
Authors: Batkin Sergey F. , Vissarionov Sergei V. , Baindurashvili Alexey G. , Agranovich Olga E. , Barsukov Dmitry B. , Buklaev Dmitriy S. , Petrova Ekaterina V. , Trofimova Svetlana I. , Kochenova Evgenia A. , Savina Margarita V.
Published: February 2022

Background. Patients with amyoplasia-type arthrogryposis and hip dislocation have different variants of hip contractures and deformities, but there is no difference in the selection of the type of surgery.
The study aimed to justify and evaluate the effectiveness of the original algorithm of the rational selection of surgical approaches in children aged 3 years with hip dislocation in amyoplasia.
Material and Methods. Level of evidence II. Seventy patients were examined, including 21 children aged 1 year (main group) who underwent 25 hip open reductions; 19 children aged 1.53 years (main group) who underwent hip open reductions, Salter innominate osteotomy, and femoral osteotomy; and 30 patients aged 37 years (control group) who had not previously received conservative and surgical treatment. All patients were divided into two subgroups depending on the variant of hip contracture: flexionextensionabductionexternal rotation (frog-like) (subgroup 1) and flexionextensionadductionexternal rotation (subgroup 2). Clinical, radiological, and statistical methods were used.
Results. In subgroup 1, after hip open reduction, good results were noted in 17% of cases, satisfactory in 50%, and unsatisfactory in 33%. Severe complications, i.e., classes III and IV according to the modified ClavienDindoSink classification, were noted in 83% of the cases. After hip open reduction, Salter innominate osteotomy, and femoral osteotomy in subgroup 1, good results were noted in 50% of cases and satisfactory and unsatisfactory each in 25%, and 50% had less severe complications (p = 0.041). In subgroup 2, after hip open reduction, good results were obtained in 90% of cases and satisfactory in 10%, and 10% had severe complications When this surgery was combined with Salter innominate osteotomy and femoral osteotomy, good results were noted in 75% of cases, satisfactory in 19%, and unsatisfactory in 6%, and 25% had severe complications (p = 0.05).
Conclusion. A differentiated treatment approach of children with hip dislocation in amyoplasia-type arthrogryposis will increase the effectiveness of treatment methods, and its introduction into clinical practice will help to improve outcomes.
Outpatient Services for People with Mental Disorders in the Kyrgyz Republic: What Is Next?
Authors: Molchanova Elena Sergeevna , Kosterina Elena Vasilevna , Yarova Olga Vasilevna , Panteleeva Lilia Yurevna
Published: February 2022

The outpatient care service for patients with mental disorders in the Kyrgyz Republic is currently experiencing various difficulties. These are largely due to a number of organizational and socio-economic problems at the state level. Treatment of patients with mental disorders is still provided in state mental health centres, while psychosocial services at the community level are only now beginning to be developed. This article describes the directions of mental health care, as well as ongoing efforts to provide outpatient care for people with mental disorders. The actions of a few prolific nongovernmental organizations (NGOs) are proving insufficient to meet the needs of patients. There is currently a gradual and visible movement toward the development of the private sector in the field of mental healthcare. In order to overcome organizational difficulties, support from government structures and certain initiatives to create legislative grounds are needed.
BIODIZINE AS A CIVILIZATIONAL CHALLENGE OF MODERN PHARMACEUTICALS
Authors: Tyukavin Alexander I. , Arseniev Nikolay  А. , Studneva Maria A. , Medvedeva Veronika S. , Suchkov Sergey V.
Published: February 2022

The review discusses the role of pharmaceutical and drug design methodology in the development of the high-tech segment of the development and production of original drugs for personalized and precision medicine (PPM). Topical issues of using predictively personalized tools for precision medicine in pharmaceuticals are highlighted. New opportunities and prospects for increasing the effectiveness of drugs in various fields of medicine created on the basis of pharmaceutical design are shown. Discussed are original approaches to standardization and reproducibility of the effects of new drugs at the preclinical stage using microfluidic bioconstructs organ-on-a-chip systems. The relevance of improving university curricula for training specialists in the field of molecular drug design (drug design), harmonized with dynamically developing biotechnologies in pharmaceuticals, as well as the needs of domestic healthcare in original medicines for PPM, is shown.
Review of the book: Zorin A.V., Sabrukova S.S., Sizova A.A. The Catalogue of Texts of the Tibetan Buddhist Canon Kept at the Institute of Oriental Manuscripts, RAS. Vol. 3: Separate Texts and Collections (I). Ed. by A.V. Zorin. St. Petersburg: St. Petersburg Centre for Oriental Studies Publishers, 2020, 660 pp. ISBN 078-5-85803-495-7 (in Russian).
Authors: Bazarov Andrei A.
Published: February 2022

The work under review is the third volume of the fundamental work "The Catalog of the Tibetan Buddhist Canon Works from the Collection of the Institute of Oriental Studies of the Russian Academy of Sciences", performed by a team of authors under the leadership of Alexander Valerievich Zorin. The first two issues (2017, 2019) were devoted to complete editions of the Buddhist kanon (Kagyura and Tengyura). This volume contains bibliographic information on individual editions of collections and treatises stored in the funds of the Institute of Oriental Studies of the Russian Academy of Sciences and which are an integral part of the Tibetan Buddhist canon.
Historical Events of 1705 in Tibet. Part 1
Authors: Garri Irina R. , Borjigidai Oyunbilig
Published: February 2022

Based on a large corpus of sources in Mongolian, Manchu and Chinese languages from the Chinese archives, the article reconstructs the history of one of the most significant events in the history of Tibet the assassination in 1705 of the Fifth Dalai Lamas regent, Sangye Gyatso, by Lhavsan Khan of the Khoshot court. The author thoroughly reproduces a cruel confrontation between the khan and the regent which ended by the latters execution and shows why the events of 1705 were of great importance for the history of the Mongols and the Tibetans. A series of events that followed, such as the death of the Sixth Dalai Lama, the enthronement of the true Seventh Dalai Lama in Kokonor, the invasion of the Dzungars in Tibet in 1717 and, ultimately, the entry of the Qing army into Tibet eventually led to the establishment of the Qing control over Tibet through the Khoshot Mongols. The author concludes that the events of 1705 became an important historical milestone that had a long-term impact on the formation of a unified multinational state under the Qing rule.
Araki Murashige’s Rebellion in the Shinchō-kō ki (Part I)
Authors: Polkhov Svyatoslav A.
Published: February 2022

This publication presents the first academic translation into Russian of books XI and XII of the Shinchō-kō ki chronicle, which is a continuation of the series of translations of this chronicle previously published by the author. One of the key sources on Japanese history of the Sengoku period, the Shinchō-kō ki (late 16th early 17thcenturies), contains a biography of Oda Nobunaga (15341582) written by his vassal Ōta Gyūichi (15271613). The translated fragments of the chronicle narrate the events connected with the rebellion of Araki Murashige, the powerful ruler of the province of Settsu, against Oda Nobunaga (15781579). The translation is supplied with a detailed commentary, in which the information of the chronicle is compared with other sources. The preface gives a brief description of main features of the Shinchō-kō ki as a historical source.
An Unattributed Miscellanea of Shi‛a Traditions (hadith)in the Collection of Arabic Manuscripts of IOM RAS
Authors: Prozorov Stanislav M.
Published: February 2022

The present research is aimed to identify the unattributed miscellanea of Shi‛a traditions (hadithes) in the collection of the Arabic manuscripts of the IOM RAS. The analysis of Shi‛a traditions ithnads and its comparison with the data from other Shi‛a authors (ash-Shaykh as-Saduk, an-Najashi, at-Tihrani, Muhammad at-Tusi) gives a foundation to affirm that it is the miscellanea Sahifat ar-Rida (Scroll of ar-Rida). It is one of authoritative and trustworthy sources of Shi‛a religious doctrine, law, cult, moral, ethics. Copies of this miscellanea are kept in the collections of Arabic manuscripts in various countries. In this context the identification of the Saint-Petersburg miscellanea of Shi‛a traditions (hadithes) may be useful for a further preparation of academic critical publication of Sahifat ar-Rida.
Miscellany on the Tumshuqese Documents: Part II
Authors: Ogihara Hirotoshi
Published: February 2022

The present article is part of the research on Tumshuqese (for Part I see Central Asiatic Journal, 2020, vol. 63, no. 12. pp. 1124). Among Middle Iranian languages, linguistic research on Tumshuqese has been much delayed because of the insufficient documentation, and the lack of the parallel texts written in other languages which leads to the comparative study. However, the secular documents, especially the contracts, are the most important material for the linguistic study of this language in view of the fact [1] that Tumshuqese contracts offer the best preserved texts and [2] that some passages are comparable to the contracts written in other Central Asian languages. In this paper, an attempt will be made to elucidate following Tumshuqese words attested in the secular documents: the numerals tshārsa forty, hodad1a seventy, sod1u hundred, dṛd1a- third and words of measure jaha- and khaa- in addition to a noun dau/do gift. Among them, the numerals tshārsa forty and hodad1a seventy are recognized for the first time. Although other words have been more or less known to scholars, different meaning and/or analysis have been assigned to them.
The Golden Poluo in Sogdiana: an In-depth Analysis of the Suishu and Tongdian Passages
Authors: Grenet Frantz , Ching Chao-jung
Published: February 2022

This paper is based on our preparation of the seminar Nouvelle approche des sources chinoises (principalement le Tongdian) sur lAsie centrale louest des Pamirs at the Collge de France since autumn 2020. We assume that the golden poluo (ultimately from Sanskrit pātra- ?) mentioned in the entry on Cao (Ishtīkhan) in the Suishu was a huge container of sharbat or another beverage or soup, serving the poor people and worshippers around the temple of Takhsīch. The big cauldron at Khodja Akhmed Yasawi (Kazakhstan) may be a continuation of this Zoroastrian practice, of which evidence in the Anthologie de Zādspram is detectable. As to the gold poluo presented by the Tsenpo of Tubo to the Tang court in 658 and the silver one by the king of Qiuci in 675, they were both likely wine drinking vessels carefully chosen for celebrating the restoration of the Tang power in the Tarim Basin after the turbulence in the middle 650s and in the late 660s, respectively.
The Tenth St. Petersburg Seminar of Tibetan Studies (St. Petersburg, October 18, 2021)
Authors: Alexander Zorin V.
Published: February 2022

On October 18, 2021, the 10th St. Petersburgtibetological readings. They heard 13 reports prepared by representatives of the IOM RAS, St. Petersburg State University, Datsan Gunzechoinei, the Institute of Oriental Studies, the MAE RAS, two publishing houses of Buddhist literature, as well as (via video link) the Parisian Higher School of Practical Research. Most of the reports were accompanied by presentations.
In Memory of the Eminent Kurdish Scholar Muhammad Mukri
Authors: Yusupova Zare A.
Published: February 2022

The article is dedicated to the 100th anniversary of the prominent Kurdish scholar, researcher of Kurdish and Iranian culture, M.Mukri (19212007). It contains an overview of his major works, the most prominent of which are studies of the Kurdish religious movement known as the Ahl-i haqq, regarded by some scholars as an Islamic sect and considered by some others to be a non-Moslem ethno-confessional community with a rich religious and spiritual literature of its own, written in the South-Kurdish dialect Gorani. In addition, M.Mukri wrote a number of serious works on Kurdish folklore, ethnography and the history of development of Kurdish studies.
Seminar in Memory of A.A. Freiman (St. Petersburg, May 19, 2021)
Authors: Chunakova Olga M.
Published: February 2022

On May 19, 2021, after a one-year break, a meeting of the Iranian seminar Freiman Readings was held, bearing the name of the outstanding Iranian philologist, Corresponding Member of the USSR Academy of Sciences, Doctor of Philology Alexander Arnoldovich Freiman (1879-1968). The seminar was attended by employees of the Eastern Faculty of St. Petersburg University (SPbSU), the State Hermitage (GE), the National Research University Higher School of Economics (NRU HSE) and the Institute of Oriental Manuscripts of the Russian Academy of Sciences (IOM RAS), who shared with the gathered results of their latest scientific research. The speeches of the seminar participants were devoted to a wide range of problems associated with Iranian studies, namely, with the study of modern Iranian and Central Iranian languages, textual criticism and the history of oriental studies.
Review of the book: Sokthan Yeng Buddhist Feminism: Transforming Anger against Patriarchy.
London: Palgrave Macmillan, 2020, xii + 152 pp. ISBN 978-3-030-51162-3
Authors: Burmistrov Sergei L.
Published: February 2022

The importance of feminist ideology for modern culture and society is well known. There are also quite a few studies devoted to the role of the religious-philosophical systems of the East in the culture of the modern West. However, as far as we know, no one has yet studied the possible significance of the cultures of the East for feminist ideology. The ideology of feminism, in order to reinforce its positions, attracts, among other things, the Buddhist teaching, rethinking it so that it becomes a means of achieving the political goals of the feminist movement from an independent phenomenon of world culture. The book under review clearly shows how the concepts of anger and oppression developed in feminism, through the prism of which Buddhism is viewed, make it just one of the elements of feminist ideology.
Pemetaan dan Alternatif Pemanfaatan Limbah Cangkang Rajungan di Indonesia
Authors: Kiki Puspita Amalia  , Ekayani Meti , Nurjanah Nurjanah
Published: February 2022

Pasteurized crab meat merupakan salah satu ekspor terbesar komoditas hasil perikanan di Indonesia. Unit pengolahan ikan (UPI) menerima bahan baku berupa daging rajungan dari miniplant, hal ini menyisakan limbah rajungan yang cukup besar karena sekitar 50-60% bagian tubuh rajungan adalah cangkang. Penelitian ini bertujuan memetakan rantai pasok terkait pemanfaatan limbah rajungan, termasuk menghitung potensi limbah, nilai ekonomi dan identifikasi alternatif pemanfaatan limbah rajungan. Metode yang dilakukan dengan deskripsi kualitatif, benefit transfer, dan analisis pendapatan. Data hasil penelitian memetakan rantai pasok terkait pemanfaatan limbah rajungan di delapan provinsi berdasarkan pada 37 UPI yang mengolah pasteurized crab meat dan 148 miniplant di sembilan provinsi pemasok bahan baku. Berdasarkan pilihan utama alternatif pemanfaatan oleh responden, jumlah cangkang yang tersedia di setiap provinsi dan nilai ekonomi yang tinggi dari kitosan maka limbah cangkang sangat potensial jika dimanfaatkan sebagai sumber bahan baku kitin dan kitosan.
Entrenamiento y rehabilitación de la marcha en pacientes pediátricos a través de la plataforma robótica CPWalker
Authors: Bayón Cristina , Lerma Lara Sergio , Ramírez Óscar , Serrano José Ignacio , del Castillo María Dolores , Belda-Lois Juan Manuel , Martínez Ignacio , Rocón Eduardo
Published: February 2022

La Parálisis Cerebral (PC) está relacionada con un trastorno de la postura y el movimiento debido a una lesión ocasionada en el cerebro cuando éste no se ha desarrollado completamente. Al ser una de las discapacidades más prevalentes a edades tempranas, la investigación y el desarrollo de dispositivos robóticos para la rehabilitación de la marcha en estos pacientes ha incrementado en los últimos tiempos. Sin embargo, los dispositivos actuales están enfocados sólo en controlar trayectorias de movimiento, olvidando el control postural del usuario y la adaptación de la terapia a las necesidades específicas de cada paciente. Este documento presenta los resultados preliminares de la aplicación de una nueva plataforma robótica (CPWalker) en la rehabilitación de la marcha de niños con diplejía espástica, durante una validación de cinco semanas. CPWalker está formado por un andador inteligente con sistema de control de peso y locomoción autónoma y un exoesqueleto robótico que realiza el movimiento guiado de las articulaciones. Además, el dispositivo incluye la posibilidad de mejorar el control postural del paciente durante la marcha, adaptando la terapia a las necesidades demandadas por el usuario.
Modelo cinemático y dinámico del robot UHP en el modo de rehabilitación Wrist
Authors: Mancisidor Aitziber , Zubizarreta Asier , Cabanes Itziar , Bengoa Pablo , Sesar Íñigo
Published: February 2022

Una de las tareas más críticas de la robótica de rehabilitación es controlar la interacción entre el robot y el paciente. El diseño de un controlador adecuado y robusto requiere de un modelo preciso del robot, por ello, en este trabajo se presenta el modelo cinemático y dinámico del UHP. El Universal Haptic Pantograph (UHP) es un robot de rehabilitación configurable, idóneo para realizar ejercicios de brazo y/o muñeca, siendo este último el objetivo de este artículo. Para resolver el modelo cinemático, se emplean ecuaciones de cierre vectoriales, mientras que se aplica la formulación Lagrangiana para estimar la fuerza de interacción. Con el fin de demostrar la eficiencia del modelo, se han realizado varias pruebas experimentales. Los resultados demuestran que el error medio de movimiento es de 1mm, mientras que el error estimado de fuerza es menor del 10%.
Técnicas de segmentación en imágenes SLAR para la detección de vertidos de hidrocarburos
Authors: Mira Damián , Alacid Beatriz , Gil Pablo , Torres Fernando
Published: February 2022

En este artículo se presentan dos métodos de segmentación para la detección de vertidos de hidrocarburos en la superficie marítima a partir de imágenes obtenidas por un sensor SLAR embarcado en una aeronave. Para ello, se describen y comparan dos aproximaciones de segmentación, basadas en grafo e imagen-J, respectivamente. Finalmente, se muestra el resultado de aplicar ambas aproximaciones a imágenes SLAR, buscando como objetivo detectar la mayor área de vertido en la superficie marina al tiempo que se minimiza la falsa detección de ésta.
Control basado en Reset para seguimiento de consigna en el sistema de Control de Crucero Adaptativo
Authors: Costas Adriana , Cerdeira-Corujo Miguel , Barreiro Antonio , Delgado Emma , Baños Alfonso
Published: February 2022

Dentro del funcionamiento del sistema de Control de Crucero Adaptativo (ACC) en modo seguidor, se explora el potencial de los controladores reseteados para obtener una mejor respuesta del sistema ante cambios en la distancia de seguridad deseada con respecto al coche delantero que el conductor puede realizar. Se han considerado dos leyes de espaciado diferentes: espaciado constante y espaciado dependiente de la velocidad.
El PIB de Canarias y de sus economías insulares. Reflexiones sobre su cálculo y
aproximación al impacto de la COVID-19
Authors: Lorenzo Díaz Domingo Jesús , Díaz Fariña Eugenio , Díaz Hernández Juan José
Published: February 2022

En este trabajo se aborda, en primer lugar, la sobreestimación del Producto
Interior Bruto de Canarias en la Contabilidad Regional de España del INE, derivada de la
asignación proporcional al Valor Añadido Bruto de los impuestos netos sobre los
productos estatales entre las comunidades autónomas, sin considerar las particularidades
fiscales del archipiélago canario. En segundo lugar, exponemos brevemente el método de
estimación del PIB insular de Canarias que sigue el Instituto Canario de Estadística
(ISTAC) con el que estimamos el PIB de cada una de las islas del archipiélago hasta el
año 2019, adelantando un año la estadística oficial, y la adaptación metodológica que
realizamos para el año 2020 con el fin de medir el impacto económico de la COVID-19 en
el PIB de las economías insulares. Los resultados de este estudio ponen de manifiesto la
sobreestimación del PIB de Canarias por parte del INE a través de la CRE, que se estima
en un 4%. Las consecuencias asociadas a esta sobreestimación es que Canarias figura en
el periodo 2014-2020 como región europea en transición, ya que su PIB per cápita es
superior al 75% de la media de la Europa de los 27, cuando la estimación del PIB
teniendo en cuenta su sistema fiscal diferenciado sitúa este indicador por debajo de ese
valor crítico, considerándola como región menos desarrollada. Esto conlleva la pérdida
de captación de mayores recursos económicos, en forma de ayudas, desde la Unión Europea,
sin afectar significativamente la ratio de endeudamiento público autonómico. Los otros
resultados del estudio tienen que ver con el impacto del COVID-19 en el PIB de las 2
economías insulares de Canarias. Mientras que la caída del PIB del conjunto de Canarias
en el año 2020 fue del 20,77% con respecto al año anterior, por islas son Lanzarote y
Fuerteventura la que más se contrajeron, un 28% y 30%, respectivamente. Por el
contrario, las islas donde menos se contrajo la economía fueron El Hierro (-10%) y La
Palma (-13%).