bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world experience with capmatinib in MET exon 14-mutated non-small cell lung cancer (RECAP): a retrospective analysis from an early access program
Authors: Illini Oliver , Fabikan Hannah , Swalduz Aurélie , Vikström Anders , Krenbek Dagmar , Schumacher Michael , Dudnik Elizabeth , Studnicka Michael , Öhman Ronny , Wurm Robert , Wannesson Luciano , Peled Nir , Kian Waleed , Bar Jair , Daher Sameh , Addeo Alfredo , Rotem Ofer , Pall Georg , Zer Alona , Saad Akram , Cufer Tanja , Sorotsky Hadas Gantz , Hashemi Sayed M. S. , Mohorcic Katja , Stoff Ronen , Rovitsky Yulia , Keren-Rosenberg Shoshana , Winder Thomas , Weinlinger Christoph , Valipour Arschang , Hochmair Maximilian J.
Published: June 2022

Background:

Patients with non-small cell lung cancer (NSCLC) presenting with mesenchymal–epithelial transition ( MET) exon 14 skipping mutation have an unfavorable prognosis with standard treatments. Capmatinib is a selective MET inhibitor, which showed promising efficacy in this patient population in early trials.

Methods:

We performed a retrospective, international, multicenter efficacy and safety analysis in patients with NSCLC treated with capmatinib in an early access program between March 2019 and December 2021.

Results:

Data from 81 patients with advanced MET exon 14 mutated NSCLC treated with capmatinib in first- or later-line therapy were analyzed. Median age was 77 years (range, 48–91), 56% were women, 86% had stage IV disease, and 27% had brain metastases. For all patients, the objective response rate (ORR) to capmatinib was 58% (95% CI, 47–69), whereas it was 68% (95% CI, 50–82) in treatment-naïve and 50% (95% CI, 35–65) in pretreated patients. The median progression-free survival was 9.5 months (95% CI, 4.7–14.3), whereas it was 10.6 months (95% CI, 5.5–15.7) in first-line and 9.1 months (95% CI, 3.1–15.1) in pretreated patients. After a median follow-up of 11.0 months, the median overall survival was 18.2 months (95% CI, 13.2–23.1). In patients with measurable brain metastases ( n = 11), the intracranial ORR was 46% (95% CI, 17–77). Capmatinib showed a manageable safety profile. Grade ⩾ 3 treatment-related adverse events included peripheral edema (13%), elevated creatinine (4%), and elevated liver enzymes (3%).

Conclusion:

In patients with MET exon 14 skipping mutation, capmatinib showed durable systemic and intracranial efficacy and a manageable safety profile. This analysis confirms previously reported phase II data in a real-world setting.
Repellency and Toxicity of Selected Fractions, Identified Compounds and Blends of Commiphora africana Resin Against Bedbugs
Authors: Wairagu Norman W. , Wachira Benson M. , Githiomi Joseph K. , Oduor Nellie , Ng’ang’a Margaret M.
Published: June 2022

Bedbugs are blood-feeding arthropods that cause anemia in humans upon heavy feeding. Control measures are unsuccessful due to resistance to development, environmental pollution, and cost. There is a need to explore natural herbal-based phytochemicals to combat bedbugs. In this study, compounds from Comiphora africana resin were sequentially extracted, fractionated, identified, and evaluated against bedbugs as individual compounds and in combinations. The chemical constituents of the most active fraction were identified using Gas Chromatography-Mass Spectrometry. Results showed that the dichloromethane crude extract had the highest mean repellency (98.5% with an LC50 of 4.96 mg/L after 24 and 72 h of exposure time, respectively), similar to the positive control (neocidol). Column chromatographic separation of the dichloromethane extract yielded 9 fractions where “FR7” (eluted with 60% n-hexane in ethyl acetate) demonstrated the highest mean repellency of 79.0% with an LC50 of 10.12 mg/L after 2 and 24 h exposure times, respectively. From the identified compounds of FR7, cedrol had significantly ( P < .05) higher mean repellency (80.5%) after 6 h of exposure and toxicity (27.43 mg/L) after 24 h exposure. A six-constituent blend of compounds from FR7 [9-octadecenoic acid-ethyl-ester, octadecadien-1-ol, citronellyl formate, cedrol, n-hexadecanoic acid, (1,2)-dihydro-6-methoxy-naphthalene] had the highest mean repellency (93.4% after 12 h exposure) and toxicity (8.83 mg/L after 72 h exposure) than the other blends and individual compounds. This study reports fractions/compounds that can be used in bedbug control measures.
Acute Ischemic Stroke Presentation Masked by Falsely Localizing Motor Seizure: A Clinical Case Series
Authors: Weil Erika L. , Stitt Derek W. , Rabinstein Alejandro A. , Cascino Gregory D. , Nasr Deena M.
Published: June 2022

In this case series, we describe a novel observation in which 4 patients with acute ischemic stroke secondary to large vessel occlusion and no history of seizure present with focal seizure activity localizable to a chronic, contralateral infarct. The explanation for this phenomenon is unknown but may be due to a combination of effects involving disrupted interhemispheric inhibitory connections and epileptogenic changes involving chronically infarcted tissue.
Tobacco Use Increases the Adjusted Risk of Revision Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis
Authors: Gill Amarbir S. , Meeks Huong , Curtin Karen , Alt Jeremiah A.
Published: June 2022

Background

Large epidemiologic studies have suggested that a history of tobacco use may be associated with an increased risk of developing chronic rhinosinusitis (CRS). The impact of tobacco use on revision rates of endoscopic sinus surgery (ESS), however, remains limited.

Objective

This study seeks to define the independent risk of tobacco use (active or prior) on revision rates of ESS among a large cohort of patients with CRS.

Methods

A state population database was queried for patients age ≥18 years with CRS who underwent at least one ESS between 1996 and 2018. Demographic characteristics, history of ESS, and tobacco use status were compared across patients with CRS, using t tests for continuous variables and χ2 tests for categorical variables. Unadjusted and adjusted logistic regression models were used to understand the impact of tobacco status on revision surgery.

Results

The final analysis included 34 350 patients (29 916 CRS with no revision surgery and 4434 CRS with revision surgery). Unadjusted regression analysis demonstrated an increased odds of undergoing revision ESS (OR 1.12, 95% CI: 1.00–1.25, P = .05) among males with a history of tobacco use and CRS. Adjusted regression analysis demonstrated that the risk of revision ESS among CRS patients with a history of asthma and tobacco use was 1.72-fold, while the risk among CRS patients who were tobacco users without asthma was 1.11-fold.

Conclusion

History of tobacco use is an independent risk factor for revision ESS among patients with CRS.
Examining the adaptability and validity of interRAI acute care quality indicators in a surgical context
Authors: Wood Timothy , Chatfield Mark , Gray Leonard , Peel Nancye , Freeman Shannon , Martin-Khan Melinda
Published: June 2022

Background:

Currently, the use of quality indicators in the surgical setting may be challenged by diverse patient needs, clinical complexity, and health trajectories. Therefore, the objective of this study was to examine the adaptability of existing quality indicators to a surgical context and propose new time points.

Methods:

A multi-method approach included an environmental scan of the literature, consultation with multinational experts, and analysis of surgical patient data. Quality indicators from the nurse-administered interRAI Acute Care instrument were examined within a surgical context using secondary data from a hospital in Brisbane, Australia (N = 1006 surgical cases).

Results:

A lack of relevancy of existing time points can preclude meaningful quality indicator measurement. Definitions of some quality indicators were adapted to ensure relevancy for the surgical population. As well, a surgical baseline (measured preoperative and post-injury) and a 48-h postoperative time point were added to the existing measurement timeline.

Conclusion:

Distinct measurement timelines were created for elective and non-elective surgical patients. The use of surgery-specific time points that can be embedded into an existing Acute Care measurement framework supports consistent quality indicator reporting. This study represents the first steps towards standardized quality reporting for health information systems across different care settings.
Undernutrition and associated factors among rural pregnant women in Eastern Ethiopia
Authors: Gebremichael Berhe , Misgana Tadesse , Tamiru Dawit , Tariku Mandaras , Tesfaye Dejene , Alemu Daniel , Weldesenbet Adisu Birhanu , Dheresa Merga
Published: June 2022

Objectives:

Maternal undernutrition is a burning issue in Ethiopia. However, updated evidence is limited in the eastern part of the country; particularly the mental health-related factors of undernutrition. The study, hence, aimed at assessing the prevalence and predictors of undernutrition among rural pregnant women in eastern Ethiopia.

Methods:

A cross-sectional research was carried out at a community level among 1015 randomly selected pregnant women. A structured questionnaire was used to collect the data through face-to-face interviews. The characteristics of participants were described and summarized by frequencies, percentages, and summary measures. Logistic regression was performed to find out factors related to undernutrition.

Results:

The prevalence of undernutrition was 43.8% (95% confidence interval: 40.8, 47.0). Early marriage (adjusted odds ratio = 2.63, confidence interval: 2.00, 3.47), no antenatal care follow-up (adjusted odds ratio = 1.73, 95% confidence interval: 1.31, 2.29), inadequately diversified diet (adjusted odds ratio = 2.48, 95% confidence interval: 1.77, 3.48), current substance use (adjusted odds ratio = 1.50, 95% confidence interval: 1.02, 2.19), history of mental illness (adjusted odds ratio = 2.44, 95% confidence interval: 1.02, 5.82), and common mental disorders (adjusted odds ratio = 1.81, 95% confidence interval: 1.34, 2.43) were the significant predictors of undernutrition among pregnant women.

Conclusions:

Undernutrition was a significant public health issue among rural pregnant women. Age at first marriage, antenatal care follow-up, dietary diversity, current substance use, history of mental illness, and common mental disorder were the independent predictors of undernutrition. Therefore, the health offices of Kersa and Haramaya districts should invest their efforts to prevent undernutrition among pregnant women through nutrition counselling and education, and mental health and psychosocial support.
Use of Guideline-Based Therapy for Diabetes, Coronary Artery Disease, and Chronic Kidney Disease After Acute Kidney Injury: A Retrospective Observational Study
Authors: Madan Sunchit , Norman Patrick A. , Wald Ron , Neyra Javier A. , Meraz-Muñoz Alejandro , Harel Ziv , Silver Samuel A.
Published: June 2022

Background:

Survivors of acute kidney injury (AKI) are at a high risk for cardiovascular complications. An underrecognition of this risk may contribute to the low utilization of relevant guideline-based therapies in this population.

Objective:

We sought to assess accordance with guideline-based recommendations for survivors of AKI with diabetes, coronary artery disease (CAD), and preexisting chronic kidney disease (CKD) in a post-AKI clinic, and identify factors that may be associated with guideline accordance.

Design:

Retrospective cohort study.

Setting:

Post-AKI clinics at 2 tertiary care centers in Ontario, Canada.

Patients:

We included adult patients seen in both post-AKI clinics between 2013 and 2019 who had at least 2 clinic visits within 24 months of an index AKI hospitalization.

Measurements:

We assessed accordance to recommendations from the most recent North American and international guidelines available at the time of study completion for diabetes, CAD, and CKD.

Methods:

We compared guideline accordance between visits using the Cochran Mantel Haenszel test. We used multivariable Poisson regression to identify prespecified factors associated with accordance.

Results:

Of 213 eligible patients, 192 (90%) had Kidney Disease Improving Global Outcomes Stage 2-3 AKI, 91 (43%) had diabetes, 76 (36%) had CAD, and 88 (41%) had preexisting CKD. From the first clinic visit to the second, there was an increase in angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACE-I/ARB) use across all disease groups—from 33% to 46% ( P = .028) in patients with diabetes, from 30% to 57% ( P = .002) in patients with CAD, and from 16% to 35% ( P < .001) in patients with preexisting CKD. Statin use increased in patients with preexisting CKD from 64% to 71% ( P = .034). Every 25 μmol/L rise in the discharge serum creatinine was associated with a 19% (95% confidence interval [CI], 8%-28%) and 12% (95% CI, 2%-21%) lower likelihood of being on an ACE-I/ARB in patients with diabetes and preexisting CKD, respectively.

Limitations:

The study lacked a comparison group that received usual care. The small sample and multiple comparisons make false positives possible.

Conclusion:

There is room to improve guideline-based cardiovascular risk factor management in survivors of AKI, particularly ACE-I/ARB use in patients with an elevated discharge serum creatinine.
How Social Media, FoMO, and Isolation Influence Our Perceptions of Others Who “Break the Rules”
Authors: Scheinfeld Emily , Voorhees Heather L.
Published: June 2022

Research has suggested that social media usage increases during times of social isolation. However, rather than making users feel more connected to others, social media may cause negative mental health and relational outcomes, including a fear of missing out (FoMO). Against the backdrop of the global coronavirus disease-19 (COVID-19) pandemic, this health communication study sought to understand the impact of physical and emotional isolation (i.e., prescribed social isolation) on people as we turned to social media more frequently. As the pandemic wore on, many remained online, watching people they knew “returning to normal,” potentially creating high levels of FoMO despite disagreeing with others’ decisions. This study examines whether social media use (frequency and purpose) influences individuals’ perception of the acceptability of others’ behavior, and whether those perceptions impact individuals’ own behavioral decisions. Participants ( N = 459) from the United States were recruited from late 2021 to early 2022 to complete an anonymous online survey regarding the “acceptableness” of behavior shown in posts by friends and family. Results indicated that increased social media frequency was correlated with an increased sense of FoMO, which was significantly and positively associated with favorable perceptions of others’ behaviors, such as gathering indoors with others, even when public health officials discouraged it. However, FoMO was not significantly related to users’ personal intentions to follow public health recommendations. A post hoc analysis determined that fear of COVID-19 moderated the relationship between FoMO and the perception of others’ behavior, as well as the relationship between FoMO and behavioral intentions.
A Pitfall of Falsely Elevated ACTH: A Case Report and Literature Review
Authors: Yang Yung-Yu , Kuo Chih-Chun , Lin Ming-Hsun , Chang Chun-Yung , Hsieh Chang-Hsun , Lu Chieh-Hua
Published: June 2022

A 35-year-old woman with unintentional weight gain, hyperpigmentation of bilateral palms, and general fatigue was initially suspected of Cushing’s syndrome or adrenal insufficiency based on the isolated elevation of the plasma adrenocorticotropic hormone (ACTH) level (113.0 pg/mL) in the Siemens ACTH Immulite assay (ACTH [Immulite]). However, both of the diagnoses were excluded by screening tests including the overnight dexamethasone suppression test, the 24-hour urinary free cortisol excretion, and the ACTH stimulation test in spite of the consistent elevation of the plasma ACTH levels. We speculated that the existence of the immunoassay interference may be the underlying cause because the plasma ACTH level analyzed by the CIS Bio International ELSA-ACTH immunoassay (ELSA-ACTH) was within the normal range. After reviewing our case and several reported cases of falsely elevated plasma ACTH levels, we conclude that when discrepancy between clinical symptoms and laboratory measurements exists, medical practitioners ought to rely on formal diagnostic criteria rather than misleading laboratory results to avoid misdiagnosis or even unnecessary invasive testing and procedures. In addition, current methods for investigation and elimination of immunoassay interferences should be applied with caution due to variable efficacy and inevitable deviations.
Isolated Splenic Infarction: An Initial Manifestation of Postoperative Atrial Fibrillation
Authors: Janga Chaitra , Okoyeze Kimberley , Chan Vincent
Published: June 2022

Splenic infarction is an uncommon cause of abdominal pain. In this article, we present a case of isolated splenic infarction presenting with severe abdominal pain, nausea, and with associated generalized weakness. Computed tomography (CT) abdomen and pelvis with contrast revealed multiple splenic infarctions of the entire lower pole with occlusion of the branch splenic arteries, while CT abdomen without contrast was unremarkable. Etiology was later revealed to be thromboembolism secondary to atrial fibrillation. It was managed with anticoagulation. To our knowledge, this is the second case of splenic infarction presenting as an initial manifestation of atrial fibrillation (AF), reported in the literature.
Household Dietary Diversity and Associated Factors among Rural Residents of Gomole District, Borena Zone, Oromia Regional State, Ethiopia
Authors: Aliyo Alqeer , Golicha Wako , Fikrie Anteneh
Published: June 2022

Background

Low dietary diversity is the main public health issue in developing countries. Despite its burden, there is a paucity of information on the dietary diversity of households and related factors in rural residents of southern Ethiopia. Therefore, this study assessed household dietary diversity and associated factors among rural residents of Gomole district.

Methods

A community-based cross-sectional study design was conducted from November 1 to December 30, 2020, among 554 randomly selected rural households. Data were collected by using pretested structured face-to-face interviews about dietary intake by any household members within the past 24 h. The data were coded and entered into Epi data 3.1 and analyzed using Statistical Package for Social Sciences version 23. Both descriptive and analytic statistics were employed. Adjusted odds ratios (AORs) together with 95% confidence intervals and p values of less than 0.05 were used to declare statistical significance.

Results

Out of the total, 19% (95%; CI = 15.7–22.2) of households had adequate dietary diversity scores. The mean (±SD) dietary diversity score was 5.12 (±1.6). The most consumed food groups in the study area were cereals/grains (96.4%), condiments (salt and beverages (tea)) (84.3%) and milk and milk products (80%). The sex of the household head (AOR = 2.31, 95% CI: 1.04–5.13), bank account ownership (AOR = 2.18, 95% CI: 1.04–4.59), and livestock ownership (AOR = 4.75, 95% CI: 1.35–16.73) were positively associated with dietary diversity. However, distance to the marketplace (AOR = 0.11, 95% CI: 0.02–0.56) was negatively associated with adequate dietary diversity.

Conclusion

There is low dietary diversity among households of study area. Improving livestock rearing and bank accounts should be strengthened through strong intersectional collaboration to alleviate the problem.
Health-Related Quality of Life and Social Support of Elderly Lung and Gastrointestinal Cancer Patients Undergoing Chemotherapy
Authors: Kyriazidou Eleni , Alevizopoulos Nektarios , Dokutsidou Eleni , Kavga Anna , Kalemikerakis Ioannis , Konstantinidis Theocharis , Tsatsou Ioanna , Govina Ourania
Published: June 2022

Introduction

Increasing life expectancy has led to a higher incidence of cancer in the elderly, thus making them vulnerable and worsening their health-related quality of life (HRQoL) and their need for support.

Objective

The aim of this study was to examine the HRQoL and social support in elderly Greek lung and gastrointestinal cancer patients undergoing chemotherapy.

Methods

This was a descriptive, cross-sectional study of 104 elderly cancer patients, who were receiving chemotherapy in the outpatient department and inpatient ward of a General Hospital in Athens. The data were collected using purposive sampling between December 2019 and May 2020, and included demographic and clinical characteristics, the HRQoL questionnaire, Short Form 36 (SF36), and the Personal Resource Questionnaire (PRQ-2000).

Results

The participants' median age was 72 years; the majority were male (62.5%) and had lung cancer (57.7%). The SF36 data revealed a relatively moderate (42.7–62.61) HRQoL in most subscales. The “Pain” subscale recorded the highest score (75.0), and the “social function” subscale the lowest (42.79). The PQR-2000 indicated a satisfactory level of social support (81.65), with values ranging between 48 and 105; married patients with higher education scored more highly ( p < .05). Patients aged 65–75 years reported better HRQoL and greater social support than older patients. In addition, patients with their own family and a relatively high income reported better HRQoL and social support compared to single individuals, with low income, who were cared for by their children. Positive and statistically significant ( p < .05) correlations were found between the SF36 subscales of role functioning/physical, vitality, general health, emotional well-being and the PRQ-2000.

Conclusion

The HRQoL and social support of elderly cancer patients positively affect the course of their health. Healthcare systems and social services should address the multiplying needs of these patients with targeted interventions to support their well-being.
Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task
Authors: Toschi Chiara , El-Sayed Hervig Mona , Burghi Thiago , Sell Torben , Lycas Matthew Dominic , Moazen Parisa , Huang Li , Gether Ulrik , Robbins Trevor W. , Dalley Jeffrey W.
Published: June 2022

Negative urgency describes the tendency for rash and impulsive behaviour during negative emotional states and has been linked to a number of psychiatric disorders. However, there has been limited research on negative urgency as an explanatory mechanism for impulsivity in experimental animals. Such research has important implications for elucidating the neurobiology of negative urgency and thereby the development of future therapeutic interventions. In this study, we investigated the effects of negative urgency using a partial reinforcement schedule to increase the frequency of non-rewarded (i.e. frustrative) trials in the five-choice serial reaction time task, a widely used task to assess visual attention and impulsivity. Using a Markov chain model to analyse trial-by-trial outcomes we found that premature (i.e. impulsive) responses in the five-choice serial reaction time task were more likely to occur after a non-rewarded trial, and mostly after a previous premature trial. However, contrary to the frustration hypothesis of negative urgency, increasing the probability of reinforcement ( p(R)) from p(R) = 0.5 to p(R) = 1 increased the number of premature responses in each session. Micro and macro levels of analyses revealed that impulsivity in the five-choice serial reaction time task is governed by at least two processes, one dependent on the overall level of reinforcement hypothesised to determine the state of behavioural activation, the second dependent on trial-by-trial outcomes consistent with negative urgency effects. These processes may depend on distinct neurobiological mechanisms and have relevance for neuropsychiatric disorders that implicate impulsive behaviours dependent on positive and negative affective states.
How the COVID-19 Pandemic has Affected Transgender Community People: Findings From a Telephonic Survey in Odisha
Authors: Barik Rajesh , Pattayat Shiba Shankar
Published: June 2022

Alike any other marginalized groups of people, the unexpected outbreak of COVID-19 virus has also catastrophically damaged the lifestyle of the transgender persons in Odisha. In order to understand the life struggle of transgender people during the world pandemic, this study is an attempt to examine their life experience throughout the pandemic and their strategic plans to deal with such tragic crisis. To materialize the above cited objectives, we have conducted 30 telephonic interviews from two cities (Cuttack and Bhubaneswar) of Odisha. We asked some open-ended questions regarding their struggle to survive, family support, availability of government assistances and accessibility of basic services and their mental conditions during the pandemic time. Our finding from the survey depicts that there was much fear and insecurity among the transgender people during the pandemic time. Because of the loss of basic earnings, shortage of foods and unavailability of other basic essentials, with the sense of group solidarity, they managed to survive with meagre substances. However, lack of family support during the pandemic, exclusion from government benefits, restrictions in social mobility and the fear of COVID-19 virus infection led to increase their mental distress and made their life more miserable.
Book review: Ghanshyam Shah, Kanak Kanti Bagchi and Vishwanatha Kalaiah (Eds.), Education and Caste in India: The Dalit Question
Authors: Islam Md. Rakibul , Hossain Md Jakir
Published: June 2022

Ghanshyam Shah, Kanak Kanti Bagchi and Vishwanatha Kalaiah (Eds.), Education and Caste in India: The Dalit Question (South Asia Edition). Routledge, 2020, 232 pp., ₹995 (Hardcover). ISBN: 978-0-367-74943-9.
Restoration as world-making and repair: A pragmatist agenda
Authors: Usher Mark
Published: June 2022

The UN’s Decade of Ecosystem Restoration commenced in June 2021, with the expectation that ecological restoration will be vastly scaled-up internationally. Millions of hectares of the earth’s surface is projected to be restored, from forests and peatland to rivers, reefs and grasslands. This will transform restoration from a predominantly localized, community-driven field to a highly capitalized, professional activity. As the renowned biologist E. O. Wilson proposed, the twenty-first century certainly does look likely to be characterized by restoration. And yet, thus far, the still emerging field of ecological restoration has been dominated by the natural sciences, in both theory and practice, neglecting broader questions of how to live in and with restored landscapes. This paper contends that if restoration is to be significantly expanded over the next decade, the social sciences and humanities must be involved to ensure its purpose is given adequate scrutiny, by engaging wider publics of interest in scheme planning, design and implementation. This is crucial given the dominance of natural capital accounting in restoration, which privileges economic reasoning over alternative, more radical forms. Pragmatism, which has a substantive philosophical interest in the relationship between humans and their environment, can offer a distinctive orientation to inquiry conducive to collaboration between the natural and social disciplines. Focusing on waterway restoration in the United Kingdom, and drawing on social and natural science literature, this paper outlines a pragmatist research agenda that recognizes multiplicity in nature, advocates experimentation in human-environment relations, and foregrounds community in democratic renewal. The paper considers not only ways that pragmatism can inform restoration but how restoration can advance a pragmatist agenda for invigorating public life. This encourages scholars to think with not only against restoration, attending to composition as well as critique, as part of a political urban ecology.
Extending the Dynamic Equilibrium Model of Paradox: Unveiling the dissipative dynamics in organizations
Authors: Weiser Ann-Kristin , Laamanen Tomi
Published: June 2022

The dynamic equilibrium model of organizing has become an influential theoretical framework in paradox research. The model describes paradox management as tightrope-walking, as actors cope with paradoxical tensions through continuous microshifts. The underlying assumption is that once actors accept the paradox and support opposing poles in a consistently inconsistent manner, they can effectively manage organizational tensions. We argue that paradoxical tensions cannot be subsumed under managerial control in this way due to the emergent and unpredictable nature of paradoxes in organizations. Hence, in addition to needing to balance on a tightrope, the tightrope walker may find the rope suddenly pulled in an unexpected direction by a strong gust of wind. To advance theory development, we put forward the concept of dissipative equilibrium to better capture the temporary nature of balance and the continuous vigilance and interventions needed from management to (re)balance an organization in the presence of unexpected developments that are beyond management’s control.
Superior Labrum Anterior Posterior Clinical Exam Techniques
Authors: Pike J. Mattison , Singh Suvleen K. , Kibler W. Ben , Eichinger Josef K.
Published: June 2022

Background:

Superior labrum anterior posterior (SLAP) lesions are prevalent in athletes and the elderly. Therefore, acquiring accurate diagnoses is beneficial for improvement in return to play for athletes and quality of life. A well-done clinical examination can help detect these lesions leading to an early and accurate diagnosis.

Indications:

Being able to perform a clinical examination for diagnosing SLAP lesions is an important tool for a doctor to know. Currently, there is not a centralized location with published videos that show how to perform these examinations and describe their attributes. This video helps clinicians quickly ascertain how to perform these examinations and learn about the statistical measures associated with them.

Technique Description:

The 7 exams shown are as follows: modified dynamic labral shear (DLS) test, speed’s test, active compression test (O’Brien test), anterior slide test, crank test, Kim test, and the Jerk test.

Results:

These tests have a wide variety of statistical measures making different ones useful for specific results such as ruling in or ruling out labral lesions. The tests with the highest sensitivity are the modified dynamic labral shear test (72%) and Kim test (61%-92%). The tests with the highest specificity are the modified dynamic labral shear test (98%), anterior slide test (81%-89%), Kim test (88%-99%), and the Jerk test (94%-99%). All of these have a 95% confidence interval except DLS test.

Discussion/Conclusions:

Some of these tests are more reliable than others when diagnosing labral lesions. Since the dynamic labral shear test and Kim test have the highest sensitivity, they are the most useful tests at ruling out labral lesions. These tests along with the anterior slide test and the Jerk test are the most useful for ruling in labral lesions due to their high specificity. Even though these tests have been proven to be more reliable than others, it still matters which tests the doctors feel comfortable performing accurately for them to use in the clinical setting.
Genome-wide identification of R2R3-MYB gene family and association with anthocyanin biosynthesis in Brassica species
Authors: Chen Daozong , Chen Haidong , Dai Guoqiang , Zhang Haimei , Liu Yi , Shen Wenjie , Zhu Bo , Cui Cheng , Tan Chen
Published: June 2022

Brassica species include important oil crops and vegetables in the world. The R2R3-MYB gene participates in a variety of plant functions, including the activation or inhibition of anthocyanin biosynthesis. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in Arabidopsis, the number and sequence variation of this gene family in Brassica crops and its involvement in the natural quantitative variation in anthocyanin biosynthesis regulation are still largely unknown. In this study, by using whole genome sequences and comprehensive genome-wide comparative analysis among the six cultivated Brassica species, 2120 R2R3-MYB genes were identified in six Brassica species, in total These R2R3-MYB genes were phylogenetically clustered into 12 groups. The R2R3-MYB family between A and C subgenomes showed better collinearity than between B and C and between A and B. From comparing transcriptional changes of five Brassica species with the purple and green leaves for the detection of the R2R3-MYB genes associated with anthocyanin biosynthesis, 7 R2R3-MYB genes were co-differentially expressed. The promoter and structure analysis of these genes showed that some variations between non-coding region, but they were highly conserved at the protein level and spatial structure. Co-expression analysis of anthocyanin-related genes and R2R3-MYBs indicated that MYB90 was strongly co-expressed with TT8, and they were co-expressed with structural genes F3H, LDOX, ANS and UF3GT at the same time. These results further clarified the roles of the R2R3-MYBs for leaf coloration in Brasica species, which provided new insights into the functions of the R2R3-MYB gene family in Brasica species.
Older adults’ facial characteristics compared to young adults’ in correlation with edentulism: a cross sectional study
Authors: Skomina Zala , Kočevar Dominik , Verdenik Miha , Hren Nataša Ihan
Published: June 2022

Background

Facial ageing is a result of superficial wrinkling combined with changes to the underlying soft tissues and skeleton. The influence of tooth loss, as a geriatric characteristic, on facial appearance is still poorly explained. The aim was to evaluate the facial characteristics of older adults, correlate these characteristics with the dentition and make comparisons with young adults using a non-invasive 3D methodology.

Methods

90 participants older than 65 years, classified into 3 subgroups (edentulous, partially edentulous, toothed) and 30 young adults were evaluated. Their faces were scanned with an optical Artec 3D-scanner. Cephalometric analyses were made using the RapidForm computer program. An independent t-test and ANOVA were used for the comparisons. Pairwise, post-hoc tests were applied with respect to the significant differences (P < 0.05).

Results

The faces of older adults are wider and longer because of the longer middle facial height. Older adults also have a longer upper lip, a larger nose, a smaller nasolabial angle (due to the nasal ptosis), narrower upper- and lower-lip vermilions and larger facial and lower-facial-height angles, resulting in a flat facial profile.

The facial changes due to ageing are the most pronounced in the edentulous. In comparison with the toothed, they have a smaller facial height due to the smaller lower facial height, larger nasolabial angle, smaller mouth width, shorter upper lip and narrower lip vermilions. Their profile is flatter and their lips are more retruded.

Conclusions

The proportions of the whole face are changed in older adults and they are the most expressed when this is combined with tooth loss.
The mediation role of psychological capital between family relationship and antenatal depressive symptoms among women with advanced maternal age: a cross sectional study
Authors: Zeng Kai , Li Yang , Yang Rumei
Published: June 2022

Background

Due to changes in family policy in China, pregnancy at advanced age (30 years old or above) is prevalent. Advanced maternal age is known to be related to a variety of negative health outcomes, including antenatal depression. Family relationship quality might be an important factor for antenatal depressive symptoms among Chinese women with advanced maternal age. However, the underlying mechanisms in which family relationship quality can affect antenatal depressive symptoms among this population and how positive psychological capital (PsyCap) intervenes in this impact are not clear.

Objectives

To describe the prevalence and demographic characteristics of antenatal depressive symptoms among Chinese pregnant women with advanced maternal age, and to explore the mediation effect of PsyCap in the associations between family relationship quality and antenatal depressive symptoms.

Methods

We conducted a cross-sectional survey at a tertiary hospital in China. A total of 192 women with maternal age of 30 years or older completed the questionnaires. Data on antenatal depressive symptoms, PsyCap, family relationship quality and demographic characteristics were collected. The multiple mediation models in SPSS’s PROCESS macro were used to test whether PsyCap mediated the relationship between family relationship quality and antenatal depressive symptoms.

Results

Approximately 28.6% of participants had antenatal depressive symptoms and 6.8% reported poor family relationship quality. Participants with higher education (p = .02) and better family relationship quality (p = .00) were less likely to have antenatal depressive symptoms. PsyCap collectively (β = 1.14, p < .05), or more specifically resilience (β = 0.61, p < .05) significantly mediated the relationship between poor family relationship quality and antenatal depressive symptoms.

Discussion

The relationship between family relationship quality and antenatal depressive symptoms can be mediated by PsyCap collectively or via resilience specifically. It is important to screen antenatal depressive symptoms among pregnant women with advanced age, especially those who have poor family relationship quality. Counseling and psychotherapy initiatives for resilience-enhancing training for pregnant women at advanced age may provide a promising target to break the link between poor family relationship quality and antenatal depressive symptoms.
Distributional patterns of subchondral bone density and histopathological features of the first tarsometatarsal joint in hallux valgus feet
Authors: Ikuta Yasunari , Nakasa Tomoyuki , Sumii Junichi , Nekomoto Akinori , Adachi Nobuo
Published: June 2022

Background

Hypermobility of the first tarsometatarsal (TMT) joint is frequently identified in patients with hallux valgus (HV); however, its association with the development of osteoarthritis in the first TMT joint in such patients remains unknown. The purpose of this study was to clarify the distribution of subchondral bone density of the first TMT joint via computed tomography (CT) using Hounsfield units (HU).

Methods

Patients were divided into three groups: the osteotomy (20 feet; 20 women, mean age: 61.8 years), arthrodesis (23 feet; two men, 21 women, 71.2 years), and control group (patients without HV deformity who had undergone CT scans of the foot; 13 feet; seven men, six women, 29.7 years). The HU ratios were calculated, which were defined as the HU value of each subdivision of the subarticular spongiosa of the first TMT joint [dorsomedial (DM), dorsolateral (DL), plantomedial (PM), and plantolateral (PL)] divided by the HU values of the entire joint surface. The ratios for the osteotomy, arthrodesis, and control groups were compared. The degradation of the articular cartilage in the first TMT joint was histologically graded in the arthrodesis group. Tukey–Kramer multiple comparison analysis was conducted to compare the HU ratios among the three groups, and the histological grade in each subdivision.

Results

The arthrodesis group demonstrated high HU ratios in the DM area of the medial cuneiform, and significantly lower HU ratios in the PL area of the first metatarsal. Lower HU ratios in the DL area were observed in both the osteotomy and the arthrodesis group when compared to that in the medial cuneiform of the control group. The histological evaluation indicated nearly normal articular cartilage for all subdivided areas in both the medial cuneiform and the first metatarsal in patients with severe HV.

Conclusions

Although high subchondral bone density was identified in the DM area of the medial cuneiform in severe HV, only mild degradation was histologically observed in the articular cartilage of the first TMT joint. Our findings suggest that the indications for arthrodesis of the first TMT should be reconsidered based on the severity of the degenerative changes in the first TMT joint.
The prevalence and incidence of pharmacologically treated diabetes among older people receiving home care services in Norway 2009–2014: a nationwide longitudinal study
Authors: Teigland Tonje , Igland Jannicke , Tell Grethe S. , Haltbakk Johannes , Graue Marit , Fismen Anne-Siri , Birkeland Kåre I. , Østbye Truls , Peyrot Mark , Iversen Marjolein M.
Published: June 2022

Background

A substantial proportion of older people who receive home care services (HCS) has diabetes and requires diabetes specific monitoring, treatment and self-care assistance. However, the prevalence and incidence rates of diabetes among older people in HCS are poorly described. The aim of the study is to estimate prevalence, incidence and time trends of pharmacologically treated diabetes among older people receiving HCS in Norway 2009–2014.

Methods

This nationwide observational cohort study is based on data from two population registries. The study population consisted of persons registered in the Norwegian Information System for the Nursing and Care Sector aged ≥ 65 years receiving HCS during at least one of the years 2009–2014. The Norwegian Prescription Database was utilized to identify participants’ prescriptions for glucose lowering drugs (GLD). The period prevalence was calculated each year as persons with one or more prescriptions of GLD in the current or previous year. Incident cases were defined as subjects receiving prescriptions of GLD for the first time in the given calendar year if there were no prescriptions of any GLD for that person during the previous two years.

Results

From 2009 to 2014, the number of older people receiving HCS increased from 112,487 to 125,593. The proportion of these who received GLD increased from 14.2% to 15.7% (p < 0.001) and was significantly higher among men than women. The annual incidence rate of diabetes among those receiving HCS showed a decreasing trend from 95.4 to 87.5 cases per 10,000 person-years from 2011 to 2014, but when stratifying on age group and gender, was significant only among the oldest women (age groups 85–89 years and 90 +).

Conclusions

The increasing prevalence of older people with diabetes who receive HCS highlights the importance of attention to treatment and care related to diabetes in the HCS.
Effect of hyperthermic intraperitoneal chemotherapy in combination with cytoreductive surgery on the prognosis of patients with colorectal cancer peritoneal metastasis: a systematic review and meta-analysis
Authors: Li Ji , Wang An-Ran , Chen Xiao-Dong , Zhang Yu-Xin , Pan Hong , Li Shi-Qiang
Published: June 2022

Background

Peritoneal metastasis often occurs in patients with colorectal cancer peritoneal metastasis, and the prognosis is poor. A large body of evidence highlights the beneficial effects of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on survival, but to date, there is little consensus on the optimal treatment strategy for patients with colorectal cancer peritoneal metastasis. The purpose of this study is to evaluate the impact of CRS + HIPEC on survival and provide reference for the treatment of patients with colorectal cancer peritoneal metastasis.

Methods

This systematic review and meta-analysis is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The PubMed, Embase, Cochrane, Web of Knowledge, and ClinicalTrials.gov databases were screened from inception of the review to March 11, 2022. Ten studies were included in qualitative and quantitative analysis.

Results

A total of 3200 patients were enrolled in the study, including 788 patients in the CRS and HIPEC groups and 2412 patients in the control group, of which 3 were randomized controlled trials and 7 were cohort studies. The 3 randomized controlled studies were of high quality, and the quality scores of the 7 cohort studies were all 7 or above, indicating high quality. The results showed that the OS of CRS + HIPEC group was higher than that of control group (HR: 0.53, 95% CI: 0.38–0.73; P < 0.00001, I2 = 82.9%); the heterogeneity of the studies was large. The subgroup analysis showed that the OS of CRS and HIPEC group was higher than that of PC group (HR: 0.37, 95% CI: 0.30–0.47; P = 0.215, I2 = 31%) and higher than that in CRS group (HR: 0.73, 95% CI: 0.49–1.07; P = 0.163, I2 = 44.8%); the heterogeneity of the studies was low. In the OPEN group, the OS of THE CRS and HIPEC groups was higher than that in the control group (HR: 0.51, 95% CI: 0.38–0.70; P = 0.353, I2 = 3.9%); OPEN group showed lower heterogeneity. The OS of 60–100-min group was higher than that in the control group (HR: 0.65, 95% CI: 0.49–0.88; P = 0.172, I2 = 37.4%); the heterogeneity of the studies was low. Sensitivity analysis showed that there was no significant difference in the results of the combined analysis after each study was deleted. The results of publication bias showed that the P-value of Egger and Begg tests was 0.078 > 0.05, indicating that there is no publication bias.

Conclusions

CRS + HIPEC can improve the survival rate of patients with colorectal cancer peritoneal metastasis
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
Authors: Li Qingyong , Peng Jun , Luo Yuelian , Zhou Jiaxin , Li Tailin , Cao Lin , Peng Shuling , Zuo Zhiyi , Wang Zhi
Published: June 2022

Background

Exposure to sunlight may decrease the risk of developing Alzheimer’s disease (AD), and visible and near infrared light have been proposed as a possible therapeutic strategy for AD. Here, we investigated the effects of the visible, near infrared and far infrared (FIR) light on the cognitive ability of AD mice, and found that FIR light also showed potential in the improvement of cognitive dysfunction in AD. However, the related mechanism remains to be elucidated.

Methods

Morris water maze was used to evaluate the cognitive ability of APPswe/PSEN1dE9 double-transgenic AD mice after light treatment. Western blot was carried out to detect the expression of protein involved in synaptic function and amyloid-β (Aβ) production. The protein amount of interleukin (IL)-1β, IL-6, Aβ1-40 and Aβ1-42 were determined using enzyme-linked immunosorbent assay. The mRNA level of receptors was performed using real-time quantitative polymerase chain reaction. Immunostaining was performed to characterize the Aβ burden and microglial Aβ phagocytosis in the brain of AD mice. The Aβ phagocytosis of primary cultured microglia and BV2 were assessed by flow cytometry. The energy metabolism changes were evaluated using related assay kits, including adenosine triphosphate (ATP), lactate content, mitochondrial respiratory chain complex enzymatic activity and oxidized/reduced nicotinamide adenine dinucleotide assay kits.

Results

Our results showed that FIR light reduced Aβ burden, a hallmark of AD neuropathology, alleviated neuroinflammation, restored the expression of the presynaptic protein synaptophysin, and ameliorated learning and memory impairment in the AD mice. FIR light enhanced mitochondrial oxidative phosphorylation pathway to increase ATP production. This increased intracellular ATP promoted the extracellular ATP release from microglia stimulated by Aβ, leading to the enhanced Aβ phagocytosis through phosphoinositide 3-kinase/mammalian target of rapamycin pathways for Aβ clearance.

Conclusions

Our findings have uncovered a previously unappreciated function of FIR light in inducing microglial phagocytosis to clean Aβ, which may be the mechanisms for FIR light to improve cognitive dysfunction in AD mice. These results suggest that FIR light treatment is a potential therapeutic strategy for AD.