bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN MOTIF UKIR TRADISI PADA BLOK MESIN SEPEDA MOTOR
Authors: Afrizal Afrizal , Prabowo Rahayu Adi
Published: September 2022

ABSTRAKSeni ukir di Indonesia telah mengalami kemajuan dengan adanya ragam jenisnya, mulai dari pengembangan motif, media, teknik, dan aspek pengembangan lainnya. Dikenal di masyarakat luas bahwa seni ukir adalah sebuah tindakan pengolahan media dengan teknik cukil, gores, coret, dan pahat yang diterapkan pada media kayu, kulit, dan logam. Kekayaan seni ukir logam di Indonesia perlu ada pengembangan-pengembangan yang akan menambah ekspresi seni untuk para pengrajin dan para pegiat seni ukir logam. Pengembangan seni ukir logam diharapkan mampu memberi dampak yang nyata dalam rangka memberikan gambaran tentang alternatif pengembangan dari seni ukir yang berkembang selama ini. Fokus penerapan seni ukir logam pada sajian tulisan ini diaplikasikan pada bentuk benda yang sudah ada yaitu blok mesin sepeda motor. Sajian penelitian ini menggunakan metode aplikasi eksplorasi motif, yaitu memunculkan motif ukir tradisi yang dikemas dalam penerapannya pada blok mesin sepeda motor dengan mengaplikasikan pola motif garapan baru sesuai dengan ranah teknik ukir motif tradisi. Metode ini menuangkan motif tradisi Surakarta dan Mataram dengan gubahan pada pola mengikuti bentuk dari blok mesin sepeda motor. Kata Kunci : Seni Ukir, Logam, Blok Mesin  ABSTRACTThe art of carving in Indonesia has progressed with various types, ranging from the development of motifs, media, techniques, and other aspects of development. It is known in the wider community that the art of carving is an act of media processing with the technique of cutting, scratching, scribbling, and chiseling which is applied to wood, leather, and metal media. The wealth of metal carving in Indonesia needs developments that will add artistic expression to craftsmen and metal carving activists. The development of metal carving is expected to have a real impact in order to provide an overview of the alternative development of carving that has developed so far. The focus of the application of metal carving in the presentation of this paper is applied to the shape of an existing object, namely the motorcycle engine block. This research presentation uses the application method of motif exploration, namely bringing up traditional carving motifs that are packaged in their application to motorcycle engine blocks by applying new patterned motifs in accordance with the realm of traditional motif carving techniques. This method expresses the traditional motifs of Surakarta and Mataram with compositions in a pattern following the shape of the motorcycle engine block. Keywords: Carving, Metal, Machine Block
MAKNA YANG TERKANDUNG DALAM GERAKAN TARI GANDHONG SEBAGAI BUDAYA KHAS KABUPATEN TRENGGALEK
Authors: Mawadah Ilma Maretiana , Setyawan Bagus Wahyu
Published: September 2022

Culture can give a sense of identity to group members. One of the things that is born from culture is art. Art can be used as an icon or identity of a region. Like in Trenggalek which has the art of Gandhong Dance which is a typical culture of the area. Culture, especially art, usually arises because of the background events. From this statement, researchers are interested in examining more deeply the origins and meanings contained in the series of movements in each stage of the Gandhong Dance. The method used is descriptive qualitative with data collection techniques through interviews and documentation studies. From the research that has been done, Gandhong Dance is an art that was born in Bangun Village, Munjungan District, Trenggalek Regency which tells about the activities carried out by farmers. This dance has four acts in the show, each act has its own meaning and is sequential from one act to another so that it resembles a storyline. The series of motions in act one tell the events of clearing land, the series of motions in act two tell the events of cultivating land, planting, weeding, and harvesting. The series of motions in the third act tells the events of the arrival of pests that attack the plants, and the series of motions in the last act tells of the farmers who kill and repel pest. Keyword: Meaning, Movement, Gandhong Dance, Culture, Trenggalek.
Media Audio Visual Sebagai Sarana Edukasi Kesehatan Reproduksi pada Remaja
Authors: Wahyuni Seri , Arisani Greiny
Published: September 2022

endidikan kesehatan reproduksi sangat penting untuk diberikan kepada remaja karena mereka rentan terhadap masalah kesehatan reproduksi remaja. Pemberian pendidikan kesehatan kepada remaja melalui media audio visual akan memaksimalkan upaya mereka dalam menyerap informasi. Menganalisis keefektifan media pendidikan kesehatan terhadap tingkat pengetahuan dan sikap tentang kesehatan reproduksi remaja. Desain penelitian adalah quasi-experimentesain penelitian pre-post test with control group. Jumlah sampel 60 orang, 30 sampel kontrol dan 30 sampel intervensi. Besar sampel diambil dengan teknik non-probability sampling dan pengumpulan data dengan kuesioner yang dianalisis dengan uji Mann-Whitney. Skor pengetahuan remaja tentang kesehatan reproduksi meningkat secara signifikan pada kelompok intervensi (41,40) lebih tinggi dibandingkan kelompok kontrol (19,60). Skor sikap kelompok intervensi (36,25) lebih tinggi dari kelompok kontrol (24,75). Pendidikan kesehatan reproduksi dengan media video lebih efektif dalam meningkatkan skor pengetahuan (Pv=0,000) dan skor sikap (Pv=0,011) dibandingkan dengan media booklet.
Influencia de la cocina fusión en la ampliación de la oferta gastronómica en la ciudad de Portoviejo
Authors: Bermúdez-Cevallos Gema , Valdés-Pérez Dayana
Published: September 2022

La oferta gastronómica de un país no solo representa su cultura, sino que contribuye a su desarrollo turístico. El objetivo de esta investigación fue analizar la influencia de la cocina fusión en la ampliación de la oferta del turismo gastronómico local en la ciudad de Portoviejo, provincia de Manabí. El estudio fue del tipo descriptivo y de enfoque mixto no experimental, se aplicaron instrumentos de recolección de datos como fichas de observación, encuestas, entrevistas y el análisis FODA. Entre los principales resultados desatacan la oferta de alrededor de 22 platos de cocina fusión, asentados en el fichaje realizado el primer semestre del año 2022, con una base de ingredientes típicos de la localidad, como maní, plátano, cereales y mariscos. Son siete los restaurantes que promueven este tipo de cocina a través de la creación e implementación de platos innovadores en la oferta culinaria, los cuales gozan de una considerable aceptación de la población local. Si embargo, la investigación demostró que la cocina fusión constituye una alternativa viable para potenciar los productos culinarios innovadores que oferta la ciudad de Portoviejo, porque le dan realce a su designación de ciudad creativa en el ámbito gastronómico, pero aún no está completamente posicionada en el mercado turístico, debido a varios factores, entre los que se destacan, la gestión administrativa local.

Palabras Clave: Cocina fusión, desarrollo turístico, cocina creativa, innovación gastronómica.
Estrategia de marketing digital para mejorar la captación de clientes en empresas de ventas directas en el Cantón Manta, Manabí-Ecuador
Authors: Arreaga-Arroyo Erika , Alvarez-Tituano Vicente
Published: September 2022

En el presente trabajo se busca conocer las acciones, retos y limitantes en el manejo de estrategias de marketing digital para mejorar la captación de clientes en empresas de venta directa en el cantón Manta perteneciente a la provincia de Manabí.  Para lo cual se realizó un análisis cualitativo y cuantitativo mediante la aplicación de entrevistas y encuestas, identificándose, que el factor común de dichas empresas es manejar estrategias SEO, SEM y especialmente las estrategias SMM, las cuales son desarrolladas explícitamente a través de redes sociales. Además, se destaca que para el desarrollo de dichas estrategias en su mayoría lo han realizado sin previa planificación o preparación profesional a causa de que observan una mayor captación mediante el marketing digital, priorizado por la red social Facebook y su publicidad pagada.  Concluyendo que es fundamental reestructurar y replantear la gestión de estrategias de marketing digital e implementar otras como inbound marketing, email marketing y marketing móvil.

Palabras claves: estrategias SEO, estrategias SEM, estrategias SMM, marketing digital, venta directa.
Role of Endothelial Kinin B1 Receptor on the Membrane Potential of Transgenic Rat Aorta
Authors: Batista C , Sales VM , Merino VF , Bader M , Feres T , Pesquero JB
Published: September 2022

The kinin receptors are classically involved in inflammation, pain and sepsis. The effects of the kinin B1 receptor agonist des-Arg9-bradykinin (DBK) and lipopolysaccharide (LPS) were investigated by comparing the membrane potential responses of aortic rings from transgenic rats overexpressing the kinin B1 receptor (B1R) in the endothelium (TGR(Tie2B1)) and Sprague Dawley (SD) rats. No difference in the resting membrane potential in the aorta’s smooth muscle from the transgenic and SD rats was observed. The aorta rings from SD rats hyperpolarized only to LPS but not to DBK, whereas the aorta rings from TGR(Tie2B1) responded by the administration of both drugs. DBK and LPS responses were inhibited by the B1 receptor antagonist R715 and by iberiotoxin in both cases. Thapsigargin induced a hyperpolarization in the smooth muscle of SD rats that was not reversed by R715, but was reversed by iberiotoxin and this hyperpolarization was further augmented by DBK administration. These results show that the model of overexpression of vascular B1 receptors in the TGR(Tie2B1) rats represent a good model to study the role of functional B1 receptors in the absence of any pathological stimulus. The data also show that KCa channels are the final mediators of the hyperpolarizing responses to DBK and LPS. In addition, we suggest an interaction between the B1R and TLR4, since the hyperpolarization induced by LPS could be abolished in the presence of R715.
NOVEL METHOD FOR QUANTIFYING HEPATIC STEATOSIS IN PATIENTS WITH METABOLICALLY ASSOCIATED FATTY LIVER DISEASE
Authors: Borsukov A. , Venidiktova D. , Borsukov S.
Published: September 2022

Introduction.The article presents an overview of novel complex algorithm based on methods of ultrasound steatometry, combined elastography and dual-energy X-ray absorbtiometry in “Whole body” mode in diagnostic and monitoring of metabolically associated fatty liver disease.

The purpose of the study:to assess the possibility of quantitative ultrasound steatometry using in the detection and monitoring of metabolically associated fatty liver disease.

Material and methods.157 patients were examined. The main group consisted of 47 patients with liver steatosis; 45 patients with steatohepatitis and clinically insigniﬁcant liver ﬁbrosis (F0-F1); 32 patients with steatohepatitis and clinically signiﬁcant liver ﬁbrosis (F2-F3); 33 patients with focal hepatic steatosis. We used complex algorithm based on methods of questionnaires, laboratory tests, ultrasound steatometry, combined elastography and dual-energy x-ray absorbtiometry in “Whole body” mode, liver biopsy. to determine the severity of steatosis, a scale was used: S0 – no steatosis; 2.9 dB/cm.

Results and conclusion.It is possible to use quantitative ultrasound steatometry for metabolically associated fatty liver disease, as a reference method both for the initial detection of the disease and for monitoring non-drug treatment (sensitivity 90.7%, speciﬁcity 92.4%). The optimal complex for the diagnosis and monitoring of non-drug treatment of metabolically associated fatty liver disease includes an assessment of the level of compliance, the use of quantitative ultrasound steatometry and dual-energy X-ray absorptiometry in the «Whole body» mode (sensitivity 92.8%, speciﬁcity 92.3%).
THE CHOICE OF A PERSONALIZED METHOD IN THE DIAGNOSTICS OF BREAST CANCER IN A CYST BY MEANS OF HYBRID TECHNOLOGIES UNDER ULTRASOUND NAVIGATION
Authors: Arabachyan M. , Borsukov A.
Published: September 2022

The article presents the results of the use of a new improved method of cytologic diagnostics of cancer in a breast cyst by applying hybrid technologies. By using our new created method with the application of ozone-oxygen mixture, unlike the traditional method of ﬁne needle aspiration biopsy of breast cysts with a solid parietal component, the probability of obtaining unaltered atypical cells in the punctate in the presence of malignization increases, thereby promoting the informativeness and sensitivity of this diagnostic method.
Schreibdidaktik
Authors: Lemke Valerie , Hoffmann Lea
Published: September 2022

Eine gut entwickelte Schreibkompetenz bildet eine wesentliche Schlüsselqualifikation für die gesellschaftliche Teilhabe in literalisierten Gesellschaften. Aus diesem Grund kommt auch der Schreibdidaktik als Teildisziplin der Sprachdidaktik, die sich mit der Konzeption, Diagnostik und Förderung von Schreibkompetenz auseinandersetzt, eine wichtige Bedeutung zu. Ihr Erkenntnisinteresse besteht vorrangig in der Frage, wie die Aneignung von Schreibkompetenz in Abhängigkeit von den individuellen Lernvoraussetzungen durch unterrichtliche Förderung gelingen kann.

Die Bibliografie verfolgt das Ziel, einen Überblick über zentrale Themengebiete und Konzepte der Schreibdidaktik, wie z. B. Schreibkompetenz, Schreibentwicklung, Schreibaufgaben und Schreibunterricht, zu geben. Dafür systematisiert sie einschlägige, aktuelle Literatur und führt neben Internetressourcen zentrale (Beiträge in) Zeitschriften, Sammelbände und Handbücher sowie Einführungen auf.
Turkey-European Union Migration Cooperation: Facility For Refugees In Turkey As An Example Of Migration Externalisation
Authors: ERDOĞAN Seven
Published: September 2022

Europe, including the countries having the most generous welfare regimes in the world, has emerged as a primary destination for the millions of people fleeing their homes after the multiple crisis and conflicts in the neighbourhood regions. The unprecedented migration pressure has forced Europe to develop alternative methods to ensure a better management of the migration by 2015. Some of the measures in this vein were taken jointly by the states at the European Union (EU) level. Among the many steps taken at the EU level, externalisation mechanism, aiming to share migration burden with the third countries, also existed. Turkey, cooperating with the EU on matters regarding migration for a long time as a candidate country for the EU membership, has been also added to the externalisation efforts of the Union as a third country. Facility for the Refugees in Turkey has become one of main pillars of the externalisation relation formally established in 2016 between the parties. After presenting the migration externalisation mechanism conceptually, the study presents the EU-Turkey migration cooperation and the Facility for the Refugees in Turkey consecutively. In addition to the review of the literature on the subject, the study is based on the analysis of the official documents, reports and evaluations produced by the EU institutions on European Facility for the Refugees in Turkey and the cooperation with Turkey on migration, and the news on the subject in periodicals.
ВСТАНОВЛЕННЯ ДЖЕРЕЛ ПОХОДЖЕННЯ АКТИВІВ ЯК ОБСТАВИНА, ЯКА ПІДЛЯГАЄ ДОКАЗУВАННЮ ПІД ЧАС РОЗСЛІДУВАННЯ НЕЗАКОННОГО ЗБАГАЧЕННЯ
Authors: Моргун Н. С. , Шевчук О. О. , Марчевський С. В.
Published: September 2022

Звернено увагу на способи вчинення та приховання означеного кримінального правопорушення. Зазначено, що під час досудового розслідування незаконного збага­чення важливим є те, що слідчому, прокурору першочергово слід встановити джерела походження активів особи, які не підтверджені законними підставами набуття. Рекоме­ндовано уповноваженим особам, проводячи досудове розслідування, з огляду на кримі­нальне правопорушення, передбачене ст. 368-5 Кримінального кодексу України, та орі­єнтуючись на складену ситуацію, внаслідок його вчинення, встановлювати й інші об­ставини, які не передбачені ст. 91 Кримінального процесуального кодексу України, зо­крема джерела походження активів. Такі обставини є особливостями предмета доказу­вання під час досудового розслідування незаконного збагачення.
МЕТОДОЛОГІЧНІ ЗАСАДИ РОЗРОБКИ МЕТОДИК РОЗСЛІДУВАННЯ НОВИХ (НЕ ПІДКРІПЛЕНИХ ПРАКТИКОЮ) ВИДІВ КРИМІНАЛЬНИХ ПРАВОПОРУШЕНЬ
Authors: Kоваленко A.B.
Published: September 2022

Статтю присвячено формулюванню окремих методологічних засад розробки ме­тодик розслідування нових кримінальних правопорушень. Сформульовано концептуальне питання щодо можливості та доцільності розробки вченими-криміналістами методик розслідування нових (не підкріплених практикою) видів кримінальних правопорушень. З’ясовано, що основу окремих методик розслідування складають положення «базової» методики, закріплені в КК України суттєві ознаки розслідуваного виду кримінальних правопорушень та емпіричні дані. Наголошено, що положення «базової» методики широко висвітлені у спеціальній літературі та достатньо пристосовані до адаптації на рівні окремих методик, зокрема й щодо нових видів кримінальних деліктів. Указано, що задля побудови кри­міналістичної характеристики, розробникам методик розслідування нових видів кримінальних правопорушень вірогідно доведеться самостійно здійснювати кримінально-правовий аналіз відповідних новел КК України.

Автор вважає, що роль емпіричних даних під час розробки подібних методик можуть відігравати наявна у відкритих джерелах інформація про розслідувані діяння, практика розслідування суміжних кримінальних правопорушень та передова практика розслідування таких нових деліктів. За відсутності належної емпіричної бази критеріями типізації слідчих ситуацій розслідування можуть виступити інформаційний критерій, передбачені складом правопорушення форми та способи його вчинення, загальні (зовнішні) умови досудового розслідування тощо. Доведено, що учені-криміналісти можуть та мають швидко реагувати на виникнення нових складів кримінальних правопорушень та розробляти відповідні методики їх розслідування. З огляду на відсутність сформованої судово-слідчої практики, а відтак і звичної емпіричної бази для досліджень, розробка окремих методик розслідування нових видів кримінальних правопорушень має здійснюватися із застосуванням специфічного методологічного інструментарію, який потребує подальшого розроблення та висвітлення у спеціальній літературі.
ВПЛИВ ПРАКТИКИ ЄВРОПЕЙСЬКОГО СУДУ З ПРАВ ЛЮДИНИ НА ДІЇ РОСІЙСЬКОЇ ФЕДЕРАЦІЇ ЯК КРАЇНИ-АГРЕСОРА ПРОТИ УКРАЇНИ
Authors: Кухарчук А. М.
Published: September 2022

Статтю присвячено дослідженню значення практики Європейського суду з прав людини та агресії російської федерації щодо України з 2014 року й до сьогодні, зокрема і вторгнення російських військ на територію України 24 лютого 2022 року. Зроблено висновок, що дії країни-агресора можна вважати такими, які підпадають під трактування категорії «суспільна небезпека», під яким практика Європейського суду з прав людини розуміє виняткову кризову ситуацію або надзвичайну ситуацію, яка впливає на все населення і становить загрозу для усталеного життя громади, що формує державу. Вторгнення російських військ на територію України стали наслідком виникнення гуманітарних катастроф, знищення об’єктів військової та цивільної інфраструктури, житлових будинків, а основне – порушення права на життя, регламентоване Конвенцією про захист прав людини і основоположних свобод від 1950 р. та Конвенцією проти катувань та інших жорстоких, нелюдських або принижуючих гідність видів поводже­ння і покарання від 1987 р. Визначено порушення з боку росії основоположного принципу верховенства права та інших, зокрема: принципу незастосування сили або погрози силою по відношенню до України; принципу суверенної рівності держав; принципу рівноправності і самовизначення народів та ін. Акцентовано увагу, що справа «Україна проти Росії (стосовно Криму)» є першою скаргою з серії міждержавних справ України проти росії, яку прийняла до розгляду по суті Велика палата Європейського суду з прав людини. Зроблено висновок, що рішення Європейського суду з прав людини – потужний вплив на дії російської федерації як країни-агресора у міждержавних справах за скаргами України проти Росії й у справах за індивідуальними позовами фізичних та юридичних осіб проти російської федерації у Європейському суді з прав людини.
A Political-Economic Theory of Political Time
Authors: Taylor Mark Zachary
Published: September 2022

Skowronek’s theory of “political time” is one of the most cited theories of the presidency. But it does not specify a causal mechanism. Each president merely reacts to their predecessor or to historical circumstance. Skowronek also suggests that the power of history may be diminishing over time. This paper addresses the causality issue in both instances. It argues two points. First, political time is ultimately driven by the widely perceived failure of existing political commitments to deal with a timely, deep, and prolonged economic crisis. Second, since the late 1970s, Reagan-era commitments to modern macroeconomic management strategies have been used to avoid a prolonged economic crisis. There may be sudden sharp economic downturns, but they do not affect enough voters for a long enough time to trigger a Disjunctive-Reconstructive transition. Hence the power of history has not waned. Rather, the causal nature of political time has been under-specified.
Remote structural characterization of thousands of buildings from San Jose, Costa Rica
Authors: Esquivel-Salas Luis C. , Schmidt-Díaz Víctor , Pittore Massimiliano , Hidalgo-Leiva Diego , Haas Michael , Moya-Fernández Aarón
Published: September 2022

The present work shows the implementation of a data collection strategy for characterizing large amounts of buildings efficiently by the conduction of remote surveys on 360° panoramic images and aerial photographs. A set of 7,296 buildings from the Latin American city of San José, Costa Rica were studied and characterized from a structural engineering point of view, obtaining information like occupancy type, height, type of lateral load resisting system, and structural irregularities, among others. Also, an estimation of the error of the remote surveys was performed, by contrasting its results with the ones of field (in situ) surveys applied on a subset of 556 structures denominated “control buildings.” The results show that for San José buildings, the predominant occupancy type, height, type, and material of the lateral load resisting system are, respectively, residential, one or two storey, wall type of confined-reinforced masonry. The overall precision level estimated for the remote surveys was 75 %, which the authors consider acceptable and an improvement when compared to more popular surveys, for example, the field surveys carried out during a population and housing census that typically have an estimated precision level of 50 %. The results proved the adopted strategy to be a promising one, albeit subject to improvements to increase its precision and reduce the implementation time.
Gene editing monkeys: Retrospect and outlook
Authors: Liang Weizheng , He Junli , Mao Chenyu , Yu Chengwei , Meng Qingxue , Xue Jun , Wu Xueliang , Li Shanliang , Wang Yukai , Yi Hongyang
Published: September 2022

Animal models play a key role in life science research, especially in the study of human disease pathogenesis and drug screening. Because of the closer proximity to humans in terms of genetic evolution, physiology, immunology, biochemistry, and pathology, nonhuman primates (NHPs) have outstanding advantages in model construction for disease mechanism study and drug development. In terms of animal model construction, gene editing technology has been widely applied to this area in recent years. This review summarizes the current progress in the establishment of NHPs using gene editing technology, which mainly focuses on rhesus and cynomolgus monkeys. In addition, we discuss the limiting factors in the applications of genetically modified NHP models as well as the possible solutions and improvements. Furthermore, we highlight the prospects and challenges of the gene-edited NHP models.
The “save the earth!” narrative creates a narrative trap for climate advocates
Authors: Laird Frank N.
Published: September 2022

The phrase “Save the Earth!” encapsulates a common narrative among climate advocates, one of environmentalists battling polluters to save Mother Earth from being despoiled. In this narrative the moral boundaries are clear and the stakes are apocalyptic, leaving no room for doubt or compromise. Nonetheless, the narrative has not been an effective one for climate activists. Most importantly, it does not lay out a path for overcoming the deeply institutionalized barriers to transforming a large sociotechnical system. Climate advocates need a new narrative, one that continues to stress decarbonizing the economy but also emphasizes adapting to climate change that is already in the pipeline and ensuring a just transition that does not harm the most vulnerable parts of the population nor frustrate the aspirations of people around the world who seek better lives for themselves. The burgeoning field of just energy transitions encompasses these concerns, but it too needs a new story, one that avoids the narrative traps that have hampered climate policy more generally.
Drivers of rainfall trends in and around Mainland Southeast Asia
Authors: Skliris Nikolaos , Marsh Robert , Haigh Ivan D. , Wood Melissa , Hirschi Joel , Darby Stephen , Quynh Nguyen Phu , Hung Nguyen Nghia
Published: September 2022

Observational rain gauge/satellite and reanalysis datasets since the 1950s are evaluated for trends in mean and extreme rainfall in and around Mainland Southeast Asia (MSEA). Rain gauge data indicate strong increases exceeding 50% in both annual mean precipitation and various extreme precipitation indices over Vietnam and the northwestern part of the peninsula since 1979. The remote influence of ENSO may partially explain the recent precipitation trend toward a more intense regional hydrological cycle, in response to predominant La Niña states over recent decades. Increasing precipitation in MSEA is also associated with increased monsoon intensity in southeast Asia and a northward shift of the monsoon activity center toward MSEA over 1979–2018. Warming-driven evaporation increases were obtained over the adjacent seas typically feeding precipitation over MSEA associated with a shift toward predominantly positive phases of the two major natural climate variability modes of the tropical Indian Ocean, namely the Indian Ocean Dipole and the Indian Ocean Basin Mode. A moisture budget analysis using ERA5 re-analysis data showed increasing oceanic moisture transports along the typical winter and summer moisture pathways toward the MSEA. However, results show that during summer the major part of increased moisture from the oceanic moisture sources ends up as precipitation over the oceanic regions adjacent to MSEA with ERA5 not being able to produce the observed positive trends in summer continental precipitation. On the other hand, ERA5 reveals pronounced increases in winter precipitation over the MSEA, in accordance with rain-gauge data, associated with strongly increasing transport of moisture originated from the western tropical Pacific and the South China Sea.
COVID-19 and arrhythmia: The factors associated and the role of myocardial electrical impulse propagation. An observational study based on cardiac telemetric monitoring
Authors: Cozzolino Domenico , Romano Ciro , Nevola Riccardo , Marrone Aldo , Umano Giuseppina R. , Cuomo Giovanna , Rinaldi Luca , Adinolfi Luigi E. ,   Vanvitelli COVID Collaborators
Published: September 2022

Background

The heart is commonly involved in COVID-19, and rhythm disorders have been largely reported.

Objective

To evaluate the association of some non-cardiac and cardiac comorbidities and QT dispersion with arrhythmias and their impact on outcomes in hospitalized patients with COVID-19.

Methods

Each patient underwent cardiac telemetry monitoring through the entire hospitalization period, laboratory analyses, 12-lead ECG, and lung imaging examination. Patients with arrhythmia were divided into three groups (bradyarrhythmias, tachyarrhythmias, and tachy- and bradyarrhythmias).

Results

Two-hundred patients completed the study (males, 123; mean age, 70.1 years); of these, 80 patients (40%) exhibited rhythm disorders on telemetry. Patients with arrhythmia were older (p < 0.0001), had a greater number of comorbidities (p < 0.0001), higher values of creatinine (p = 0.007), B-type natriuretic peptide (p < 0.0001), troponin (p < 0.0001), C-reactive protein (p = 0.01), ferritin (p = 0.001), D-dimer (p < 0.0001), procalcitonin (p = 0.0008), QT interval (p = 0.002), QTc interval (p = 0.04), and QTc dispersion (p = 0.01), and lower values of sodium (p = 0.03), magnesium (p = 0.04), glomerular filtration rate (p < 0.0001), and hemoglobin (p = 0.008) as compared to patients without arrhythmia. By comparing the three subgroups of patients, no significant differences were found. At multivariate analysis, age [odds ratio (OR) = 1.14 (95% CI: 1.07–1.22); p = 0.0004], coronary artery disease [OR = 12.7 (95% CI: 2.38–68.01); p = 0.005], and circulating troponin [OR = 1.05 (95% CI: 1.003–1.10); p = 0.04] represented risk factors independently associated with arrhythmia. All-cause in-hospital mortality was ∼40-fold higher among patients with arrhythmia [OR = 39.66 (95% CI: 5.20–302.51); p = 0.0004].

Conclusion

Arrhythmias are associated with aging, coronary artery disease, subtle myocardial injury, hyperinflammatory status, coagulative unbalance, and prolonged QTc dispersion in patients with COVID-19, and confer a worse in-hospital prognosis. Given its usefulness, routinary use of cardiac telemetry should be encouraged in COVID wards.
Enhancing attitudes and self-efficacy toward inclusive teaching in physical education pre-service teachers: Results of a quasi-experimental study in physical education teacher education
Authors: Grimminger-Seidensticker Elke , Seyda Miriam
Published: September 2022

As many teachers feel overwhelmed by teaching inclusively, teacher education programs have to find ways to prepare them for this future challenge. Due to particular conditions, physical education (PE) teachers might be a particular target group in this context. With regard to the state of research, there is a need to identify inputs or learning situations that might improve the best physical education teachers’ competencies and underlying cognitive and affective-motivational aspects, such as attitudes, self-efficacy, or stress perception, to empower physical education teachers for teaching physical education inclusively. Practical experiences seem to be a key aspect in this context. Therefore, we conducted a quantitative evaluated quasi-experimental intervention study with physical education pre-service teachers to test different forms of promoting inclusion competencies and their underlying cognitive and affective-motivational constructs. Intervention group 1 (IG 1) followed an information-based seminar, whereas intervention group 2 (IG 2) was also taught theoretical units in combination with practical lessons in the gym that were prepared and conducted by the pre-service teachers themselves. The control group (CG) did not receive any specific information or practical experiences on inclusively teaching physical education. We first hypothesized that both intervention groups (IG 1 and IG 2), in contrast to the control group, would significantly improve their attitudes toward inclusion and the self-efficacy to teach inclusively, and would decrease their perceived stress related to teaching physical education inclusively (hypothesis 1). Second, we hypothesized that participants of intervention group 2 would have a significantly stronger increase in positive attitudes toward inclusion, a stronger increase in self-efficacy, and a greater decrease in the level of perceived stress related to teaching physical education inclusively than participants of intervention group 1 (hypothesis 2). Based on ANCOVA analysis, we found significant results for some subscales of the attitudes, but no significant results for stress perception and self-efficacy. In total, the teaching strategy in intervention group 2 seemed to work best in enhancing physical education pre-service teachers’ inclusion competencies.
Impact and mechanism of rural labor migration on forest management income: Evidence from the Jiangxi Province, China
Authors: Ning Caiwang , Xie Fangting , Xiao Hui , Rao Pan , Zhu Shubin
Published: September 2022

This article explores how rural labor migration affects the forest management income. Based on consecutive annual surveys of 397 forest households in the Jiangxi Province from 2011 to 2018, the panel-Tobit and IV-Tobit and mediation models are conducted. The studies showed that the migration effect of labor migration inhibits forest management income, and the remittance effect of labor migration has a promoting effect, but the total effect of labor migration inhibited household forest management income. A heterogeneity analysis showed that, the labor migration effect in hilly and mountainous areas has a significant inhibitory effect on forest management income, while the promoting effect of the remittance effect of labor migration on forest management income is only significant in plain areas. At the same time, compared with the elderly group, the migration effect of labor migration of the youth group has a greater inhibitory effect on household forest management income, while the impact of the remittance effect of labor migration is only significant in the elderly group. A test of action mechanism showed that, cash investment plays a partial mediating role on the impact of labor migration effect on forest management income, but it has a suppressing role in the impact of the remittance effect. Labor input plays a partial mediating role on both the labor migration effect and the labor remittance effect on forest management income. Our analysis provides an important basis for policymakers to formulate pertinent policies to support forest management in collective forest regions.
Mega shopping malls technology-enabled facilities, destination image, tourists’ behavior and revisit intentions: Implications of the SOR theory
Authors: Al-Sulaiti Ibrahim
Published: September 2022

Mega shopping malls technology-enabled services influence tourists shopping behavior as Jumbo malls offer a broader range of products and services with innovative features that impacts revisit intentions. This study’s novelty is the research on mega shopping malls as literature lacs it. Travel, leisure, and tourism sectors have gained balanced attention, and scholars have contributed with academic research perspectives. Mega malls in modern cities attract tourists that help foster economic development with revisit intentions. Technology-enabled products influence sustainable tourists’ experiences. Despite broad investigative studies on tourists’ experiences, literature shows little regarding tourists’ shopping experiences in mega shopping malls that lead to reviewing tourist destination choices. This narrative research explores how shopping malls attributes influence tourists’ behavioral intentions in mega malls’ shopping environments that satisfy them for revisiting intentions in the future. Doha city is an economic hub that plays a crucial role in the economic and social development of the region. The city lies on the sea and has many mega shopping malls that offer technology-enabled products and services to attract regional and global tourists. It boosts sustainable economic activities, climate change, and environmental protection concerns. The city of Doha oscillates widespread beaches, and its mega shopping malls are famous as tourist attractions for domestic, regional, and global travelers. As an independent and economically affluent country, it has its take on attracting tourists. The study aimed to examine the revisiting behavior of Doha tourists with destination revisit intentions. A pleasant shopping experience in sizeable technology-enabled shopping malls is critical for tourist satisfaction. The trust, perceived value, and environmental effects affect tourists’ revisit intentions. Other factors include high spirits, excitement, new tourist destinations, and visiting friends. External factors include a preference for natural and historical destinations, technology-enabled facilities, infrastructure, safety, affordability, comfort, budget range, and sociocultural factors. The study recommends future inquiries based on factors that empirically test mega malls’ technology-enabled product effects on tourists’ behaviors. The findings not only contribute to tourists’ experiences in mega shopping malls and revisit intention literature but also provide implications’ for officials and policymakers to articulate policies that promote tourists’ mega-mall shopping experiences and destinations.
PD-1 blockage combined with vaccine therapy can facilitate immune infiltration in tumor microenvironment of Lynch syndrome colon cancer
Authors: Ye Kai , Zhong Wenjin , Wang Pengcheng , Chen Yanxin , Chi Pan
Published: September 2022

Background: Lynch syndrome is a genetic disease resulting from mismatch repair gene mutation. Vaccine therapy can enhance the immunogenicity of Lynch syndrome and improve the therapeutic efficacy of immunotherapy. However, there is no approved Lynch syndrome vaccine coming onto the market.

Methods: Herein, we used gene knockdown method to construct Lynch syndrome cell model, paving way for us to develop Lynch syndrome tumor lysate vaccine. Then the isograft technique was employed for constructing the tumor-bearing mouse model of Lynch syndrome. And this isograft model was treated with PD-1 monoclonal antibody and tumor vaccine, respectively. Flow cytometry was used for detecting the proportion of immune cells and immunosuppressive cells, and ELISA was used for detecting the contents of chemokines and cytokines in the blood circulation system and tumor tissues of mice. Finally, IHC was used to detect the effects of tumor vaccines as well as PD-1 antibody on tumor tissue proliferation and angiogenesis.

Results: The results demonstrated that tumor vaccine could prolong the overall survival of mice, and improve the disease-free survival rate of mice. The vaccine could increase the proportion of inflammatory cells and decrease the proportion of anti-inflammatory cells in the blood circulation system of mice. In addition, tumor vaccine could also improve inflammatory infiltration in the tumor microenvironment and reduce the proportion of immunosuppressive cells. The results of IHC showed that tumor vaccine could inhibit angiogenesis and tumor cell proliferation in mouse tumor tissues.

Conclusion: In colon cancer associated with Lynch syndrome, tumor vaccine can hinder the growth of tumor cells, and assist immunotherapy whose therapeutic effect on this kind of cancer is thus enhanced.
Necroptosis-related lncRNA in lung adenocarcinoma: A comprehensive analysis based on a prognosis model and a competing endogenous RNA network
Authors: Mao Fuling , Li Zihao , Li Yongwen , Huang Hua , Shi Zijian , Li Xuanguang , Wu Di , Liu Hongyu , Chen Jun
Published: September 2022

Background: Necroptosis, an innovative type of programmed cell death, involves the formation of necrosomes and eventually mediates necrosis. Multiple lines of evidence suggest that necroptosis plays a major role in the development of human cancer. However, the role of necroptosis in lung adenocarcinoma (LUAD) remains unclear. In this study, we aimed to construct an NRL-related prognostic model and comprehensively analyze the role of NRL in LUAD.

Methods: A necroptosis-related lncRNA (NRL) signature was constructed in the training cohort and verified in the validation and all cohorts based on The Cancer Genome Atlas database. In addition, a nomogram was developed. The tumor microenvironment (TME), checkpoint, human leukocyte antigen, and m6A methylation levels were compared between low-risk and high-risk groups. Then, we identified five truly prognostic lncRNAs (AC107021.2, AC027117.1, FAM30A, FAM83A-AS1, and MED4-AS1) and constructed a ceRNA network, and four hub genes of downstream genes were identified and analyzed using immune, pan-cancer, and survival analyses.

Results: The NRL signature could accurately predict the prognosis of patients with LUAD, and patients with low risk scores were identified with an obvious “hot” immune infiltration level, which was strongly associated with better prognosis. Based on the ceRNA network, we postulated that NRLs regulated the TME of patients with LUAD via cyclin-dependent kinase (CDK) family proteins.

Conclusion: We constructed an NRL signature and a ceRNA network in LUAD and found that NRLs may modulate the immune microenvironment of LUAD via CDK family proteins.
Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis
Authors: Ghosh Sweta , Moorthy Bhagavatula , Haribabu Bodduluri , Jala Venkatakrishna Rao
Published: September 2022

Background

Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical carcinogenesis and xenobiotic metabolism. Recently, we demonstrated that the microbial metabolite Urolithin A (UroA) mitigates colitis through its gut barrier protective and anti-inflammatory activities in an AhR-dependent manner. Here, we explored role of CYP1A1 in UroA-mediated gut barrier and immune functions in regulation of inflammatory bowel disease (IBD).

Methods

To determine the role of CYP1A1 in UroA-mediated protectives activities against colitis, we subjected C57BL/6 mice and Cyp1a1-/- mice to dextran sodium sulphate (DSS)-induced acute colitis model. The phenotypes of the mice were characterized by determining loss of body weight, intestinal permeability, systemic and colonic inflammation. Further, we evaluated the impact of UroA on regulation of immune cell populations by flow cytometry and confocal imaging using both in vivo and ex vivo model systems.

Results

UroA treatment mitigated DSS-induced acute colitis in the wildtype mice. However, UroA-failed to protect Cyp1a1-/- mice against colitis, as evident from non-recovery of body weight loss, shortened colon lengths and colon weight/length ratios. Further, UroA failed to reduce DSS-induced inflammation, intestinal permeability and upregulate tight junction proteins in Cyp1a1-/- mice. Interestingly, UroA induced the expansion of T-reg cells in a CYP1A1-dependent manner both in vivo and ex vivo models.

Conclusion

Our results suggest that CYP1A1 expression is essential for UroA-mediated enhanced gut barrier functions and protective activities against colitis. We postulate that CYP1A1 plays critical and yet unknown functions beyond xenobiotic metabolism in the regulation of gut epithelial integrity and immune systems to maintain gut homeostasis in IBD pathogenesis.
Tipping the scales: Immunotherapeutic strategies that disrupt immunosuppression and promote immune activation
Authors: Santiago-Sánchez Ginette S. , Hodge James W. , Fabian Kellsye P.
Published: September 2022

Immunotherapy has emerged as an effective therapeutic approach for several cancer types. However, only a subset of patients exhibits a durable response due in part to immunosuppressive mechanisms that allow tumor cells to evade destruction by immune cells. One of the hallmarks of immune suppression is the paucity of tumor-infiltrating lymphocytes (TILs), characterized by low numbers of effector CD4+ and CD8+ T cells in the tumor microenvironment (TME). Additionally, the proper activation and function of lymphocytes that successfully infiltrate the tumor are hampered by the lack of co-stimulatory molecules and the increase in inhibitory factors. These contribute to the imbalance of effector functions by natural killer (NK) and T cells and the immunosuppressive functions by myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the TME, resulting in a dysfunctional anti-tumor immune response. Therefore, therapeutic regimens that elicit immune responses and reverse immune dysfunction are required to counter immune suppression in the TME and allow for the re-establishment of proper immune surveillance. Immuno-oncology (IO) agents, such as immune checkpoint blockade and TGF-β trapping molecules, have been developed to decrease or block suppressive factors to enable the activity of effector cells in the TME. Therapeutic agents that target immunosuppressive cells, either by direct lysis or altering their functions, have also been demonstrated to decrease the barrier to effective immune response. Other therapies, such as tumor antigen-specific vaccines and immunocytokines, have been shown to activate and improve the recruitment of CD4+ and CD8+ T cells to the tumor, resulting in improved T effector to Treg ratio. The preclinical data on these diverse IO agents have led to the development of ongoing phase I and II clinical trials. This review aims to provide an overview of select therapeutic strategies that tip the balance from immunosuppression to immune activity in the TME.
Zooplankton exposure to microplastics at global scale: Influence of vertical distribution and seasonality
Authors: Richon Camille , Gorgues Thomas , Paul-Pont Ika , Maes Christophe
Published: September 2022

Microplastics (MPs) are ubiquitous contaminants in the ocean. Zooplankton is thus widely exposed to MP ingestion. Here, we use a global coupled physical–biogeochemical model enriched with a 3D representation of MPs to assess the global zooplankton exposure to MPs. As expected, our results indicate that water MP concentration is the highest in the surface layers of subtropical gyres and coastal areas close to major MP sources, which is mostly due to floating MPs, while neutral MPs contaminate the mesopelagic zone. Additionally, we showed that floating MPs may be also transported to the mesopelagic waters during the seasonal deepening of the mixed layer depth. We then estimate zooplankton exposure to MPs based on water MP concentrations, plankton biomass, and zooplankton grazing rate. Two main drivers lead to high zooplankton exposure to MPs: 1) high water MP contamination and 2) intense grazing activity. Seasonally, re-stratification of surface waters may lead to MP vertical concentration coinciding with planktonic blooms, thus increasing contamination risk.