bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediksi Penurunan Konsolidasi Tanah Lunak Dengan Metode Analitis Dan Metode Element Hingga
Authors: Surbakti Rudianto
Published: February 2022

Penurunan tanah, pergerakan tanah dan pergeseran tanah adalah masalah yang paling sering dihadapi ketika membangun konstruksi diatas lapisan tanah lunak. Tanah dengan konsistensi lunak memiliki tingkat penurunan tanah yang tinggi. Terdapat banyak metode yang dikembangkan untuk memprediksi besar total penurunan konsolidasi yang terjadi, diantaranya metode analitis dengan menggunakan teori yang dikembangkan Terzaghi atau metode element hingga menggunakan software Plaxis 2D dan 3D. Sebagai pembanding kedua metode tersebut diperlukan data harian penurunan tanah yang terjadi di lapangan dicatat dari settlement plate yang dipasang di lapangan. Analisis ini bertujuan untuk memprediksi penurunan tanah yang terjadi di lapangan menggunkan metode Terzaghi dan  metode elemen hingga secara dua dimensi dan tiga dimensi. Melalui metode analitis Terzaghi diperoleh hasil prediksi penurunan tanah -6,218 meter, dengan metode elemen hingga menggunakan plaxis 2D adalah -6,404 meter dan plaxis 3D adalah -6,356 meter. Sedangkan penurunan yang terjadi menurut pengamatan settlement plate di lapangan adalah -6,320 meter. Sehingga dapat disimpulkan prediksi penurunan konsolidasi menggunakan pemodelan Plaxis 3D memberikan hasil yang lebih mendekati penurunan hasil observasi di lapangan dibandingkan pemodelan Plaxis 2D dan metode analitis Terzaghi.
Pengaruh Tanah Timbunan Terhadap Daya Dukung Pondasi Telapak (Square Footing)
Authors: Sitompul Beni Deni , Irwan Irwan , Lubis Kamaluddin
Published: February 2022

The lower structure of a building construction consists of a foundation and a layer of soil to support the load of the upper construction. The condition of the soil under the structure is closely related to the behavior of the soil itself when it receives loads, for example failures that occur in the sub-grade of the embankment foundation, namely the foundation soil is too soft so that the carrying capacity of the soil to withstand the load of the embankment is small, as a result the settlement that occurs is too large. So the soil layer under the structure must be strong, stable, safe, so that it does not decrease, does not break, because it will be difficult to repair a foundation system. The purpose of this study was to determine the effect of embankment soil on a footing foundation and how much settlement was caused to the foundation. The Plaxis D2 V20 method is a finite element method that aims to analyze and design the geotechnical field. Soil samples were taken at the hospital. Wulan Windi, Medan City, using manual tools. The embankment soil investigation aims to determine the nature and characteristics of the embankment soil carried out at the Civil Engineering Laboratory of the Medan Area University and the Medan State Polytechnic laboratory. The results of the soil embankment research showed that the density of soil (Gs) = 2.63 gr, wet soil volume weight (γb) = 14.8512 kN/m3, dry soil volume weight (γd) = 0.3236 kN/m3, soil permeability ( K)= 12,929 cm/hour, shear stress (φ) = 23,610 . Soil cohesion (c) = 0.057 kg/cm2, Modulus of elasticity (E) = 2400 kN/m2 . Then from the results of the running plaxis, the deformation is 0.1601 meters, while that of the Steinbrenner method, the resulting decrease is 0.1232 m. which causes the plate footing of the tread foundation to fracture. The stress that occurs in the soil is 0.012 kN/m2 and from the analysis results obtained a safety factor of 1 (one).
Rancangan Strategi Portofolio Optimal PT. ABC dengan Metode Single Index Model
Authors: Saputra Ramadhan Dwi , Alifiandipura Irham
Published: February 2022

As social insurance company of the Republic of Indonesia, PT ABC (Persero) has a captive market based on the provisions of Undang-undang in Indonesia. The company has managed funds from the government, and is one of the four insurance products in the company, into an investment portfolio. As one of the company’s revenue generator, PT ABC needs to put the fund into investment instruments that have higher returns to meet the needs of the company, one of which is through stock investment. The formation of stock portfolio is carried out through an optimum portfolio approach by using single index model method. This is a quantitative descriptive research using analysis tools and data processing by Microsoft Excel software. Portfolios are formed into several scenarios by considering the composition of the current portfolio in one of the company’s products and stock price movements in Indonesia. The data used in this study are historical data on daily stock movements for the five years of the 2014-2018 trading period and historical data on the investment portfolio for XYZ products in 2018. From this research, 2 strategic plans for forming company portfolios and 1 recommendation of stocks are produced that have good resilience during a pandemic. The results of the calculations are expected to be taken into consideration by the company in the formation of future company portfolios
Analisis Kerusakan Main Bearing pada Unit Generator Mitsubishi BMGS
Authors: Arso Wilarso , Domodite Aswin
Published: February 2022

Damage to the main bearing components on the generator set unit operating in the PLTD to supply power to PLN. Based on the initial indication of engine blow-by and high vibration in the damper area of the service meter unit (SMU): 25555. The purpose of this study is to determine the root cause of the main bearing damage that changes shape and color in the diesel engine generator set. The method used in this research is a visual inspection and removing engine components. The results and discussion of the research obtained changes in the shape and color of the main bearing, starting from the main bearing material (rotating) spalling so that it rubs against the main journal. The friction that occurs causes changes in the shape of the main bearing and causes the main bearing to rotate. The keywords on the main bearing are released due to thinning so that the main bearing rotates and closes the supply of lubricating oil to the main and rod bearings. Based on the analysis, the most likely cause of adhesive wear on Main Bearing #1 is crankshaft misalignment towards the front of the engine.
Analisis Temperatur Pada Proses Extruding Pelet Apung
Authors: Darianto Darianto , Nasution Amirsyam , Idris Muhammad
Published: February 2022

Extruder is a device that consists of a screw (a type of pressure screw), the thread functions as a propulsion and presses the raw material so that it turns into a semi-solid material. The material is pushed and pressed out through a confined hole (die) at the thread end. The heater gives heat to the material being extruded which is called hot extrusion. The cutting knife is used to even out the size of the extruded cut, and the main feature of the extrusion process is its continuous nature. The extruder is operated under conditions of dynamic equilibrium, that is, the input equals the output, the incoming material is equivalent to the product.
O que significa cada letra da sigla STEM?
Authors: Freitas Lopes Andressa , Morin Ocampo Daniel , Tolentino Neto Luiz Caldeira Brant de , Dávila Eliziane da Silva
Published: February 2022

A presente pesquisa bibliográfica e exploratória, objetiva criar uma versão para o acrônimo STEM frente às demandas da educação brasileira. Assim, conceituamos: Ciência como o método da construção do conhecimento científico; Tecnologia como instrumentação para resolver problemas, envolvendo a inovação, informação e comunicação; Engenharia como processo de resolução de problemas, alicerçado no planejamento, design, construção e execução e; Matemática como linguagem para interpretar o mundo, utilizando-se da modelagem matemática. Como estratégia à integração das áreas, temos as Comunidades de Prática. Inferimos a relevância da Educação STEM, visto sua adaptabilidade aos diferentes contextos e sua relação com os preceitos da educação do Brasil.
Proposição de um modelo consensual de projeto de produtos tecnológicos para área da saúde
Authors: Alves Júlio Cesar da Rocha , Falcão Luiz Fabio Magno , Normando Valéria Marques Ferreira
Published: February 2022

O objetivo do estudo consistiu em analisar metodologias de projeto de produto difundidas na literatura, a fim de formular um modelo consensual para o desenvolvimento de projetos tecnológicos em saúde. Trata-se de um estudo descritivo baseado na revisão bibliográfica, análise e síntese de modelos metodológicos de projeto nas bases de dados digitais PubMed, Lilacs e Google Acadêmico. Foram utilizados como palavras-chave de busca os seguintes termos e operadores: (“metodologia” OR “método” OR “tecnologia”) AND (“projeto” OR “desenvolvimento” OR “design” OR “produto”). Foram incluídos na busca artigos, teses e dissertações em português, disponíveis em versão integral e publicadas no período de 2010 a 2020. A análise comparativa dos modelos selecionados se deu pela disposição dos processos em quadros comparativos, para identificar as etapas comuns e mais adequadas ao desenvolvimento de produtos para área da saúde. O resultado final do estudo foi a definição de um modelo metodológico consensual de projeto de produtos para áreas de saúde, representado em um diagrama de processos e etapas. Espera-se que o estudo contribua como um guia auxiliar no desenvolvimento de projetos em atividades voltadas ao ensino tecnológico em saúde, agregando novas tecnologias e integrando conhecimentos multidisciplinares.
JEMBATAN BERSUDUT (SKEW BRIDGE) MENGGUNAKAN BETON MUTU NORMAL UNTUK DEK DAN BETON MUTU TINGGI UNTUK GIRDER DENGAN METODE ELEMEN HINGGA DAN PONDASI SPRING
Authors: Handayani Fitria
Published: February 2022

Jembatan bersudut adalah suatu jembatan   yang   sumbu tengahnya tidak tegak Lurus terhadap jalan. Perbedaan perilaku dan karakteristik jembatan bersudut jika dibandingkan  jembatan  pada  umumnya  yaitu  pengaruhnya  terhadap  gaya  yang terjadi pada jembatan dan kekuatan jembatan memikul beban di atasnya. Penelitian ini  bertujuan  yakni:  menentukan  sudut  miring  terbesar  dari  posisi  jembatan terhadap balok beton, mendapatkan beban ultimit yang mampu dipikul jembatan bersudut, serta mengetahui perilaku retak yang terdapat pada jembatan bersudut. Asumsi Panjang jembatan 20 m dan lebar jembatan 10 m dengan perletakan sendi dan rol. Variasi sudut miring jembatan adalah 35o, 40o, 45o, 50o, 55o, dan 60o. Bentuk profil jembatan yaitu gelagar I  beton bertulang. Tegangan leleh tulangan baja yang dipakai yaitu  fy = 400 MPa sedangkan tulangan utama dan fy = 240 MPa untuk tulangan sengkang. Jumlah gelagar delapan buah profil I 1325.  Mutu gelagar beton yang digunakan adalah fc’= 53 MPa (mutu tinggi) dan mutu beton untuk dek fc’= 28 MPa (mutu normal). Jarak antar gelagar 1,2 m dengan Tebal dek 230 mm. Metode penelitian menggunakan Analisa Elemen Hingga ANSYS Ed. 9.0. Model beton balok pada ANSYS Ed. 9.0 dimodelkan menggunakan material SOLID65 dan Baja  tumpuan  dimodelkan  menggunakan  material  SOLID45.  Sedangkan  Model baja tulangan menggunakan material LINK8 dan untuk permodelan pondasi menggunakan Combine39. Input nilai tegangan regangan beton mutu normal menggunakan kurva tegangan regangan usulan Hognested dan untuk input beton mutu   tinggi   menggunakan   kurva   tegangan   regangan   usulan   Azizinamini. Sedangkan input nilai tegangan regangan multilinier dan linier baja tulangan menggunakan kurva tegangan regangan usulan Park dan Paulay (1975). Pedoman perhitungan yang dipakai yaitu SNI 03-1725-1989 untuk jembatan, SNI 03-2847-2002   untuk   beton,   dan   ACI   untuk   batas   izin   lendutan.   Hasil   penelitian menunjukkan bahwa variasi sudut miring pada jembatan mempengaruhi kekuatan balok dan pola retak. Semakin besar sudut miring jembatan semakin berkurang kemampuan balok memikul beban dan pola retak semakin besar. Defleksi terbesar terjadi pada jembatan dengan sudut kemiringan 60o. Tegangan terbesar terjadi pada jembatan dengan sudut kemiringan 60o. Pola retak yang terjadi yaitu retak lentur dan retak geser yang terjadi pada tengah bentang menuju pelat tumpuan. Kata Kunci: jembatan  bersudut,  beton bertulang, defleksi, von Misses, metode elemen hingga.
La duplicité et le mensonge dans les télécoms canadiennes
Authors: Desjardins Guillaume
Published: February 2022

Cet article analyse les comportements auto-rapportés des conseiller(ère)s de boutique ainsi que les pratiques/politiques internes de sept firmes de télécommunications canadiennes. Les résultats indiquent que les comportements de duplicité et de mensonge ne sont pas distribués de façon aléatoire dans l’industrie. L’étude propose un modèle comprenant six pratiques/politiques internes qui sont en mesure d’expliquer jusqu’à 68 % des variations de ces comportements au travail.
La métaphore familiale appliquée aux entreprises organisées en groupes de sociétés
Authors: Bouthinon-Dumas Hugues
Published: February 2022

Cet article explore une métaphore courante : le fait de désigner une société qui en contrôle une autre comme une société « mère », celle qui est contrôlée comme sa « fille » et ainsi de penser leurs relations selon le modèle de la parenté, ce qui conduit à traiter l’ensemble des entités constituant un groupe de sociétés comme une « famille ». Cette métaphore n’est en l’occurrence pas simplement un moyen commode de parler des groupes de sociétés, mais plus fondamentalement un concept essentiel pour assurer l’intelligibilité, la coordination et le bon fonctionnement d’un type d’organisation particulièrement sophistiqué par rapport à une entreprise intégrée ou à des entreprises totalement indépendantes et liées entre elles par des relations de marché.
PRODUKSI BENIH PADI GOGO YANG BERMUTU MENGGUNAKAN TEKNIK DAN WAKTU PENYIMPANAN
Authors: Priyantono Eko , Maemunah  , Khaliq Moh. Adnan , Mustakim  , Yusran
Published: February 2022

Penyimpanan sangatlah penting dilakukan untuk menghasilkan benih padi gogo yang bermutu dan berkualitas yang akan digunakan sebagai bahan tanam selanjutnya. Tujuan dari penelitian ini ialah untuk mendapatkan teknik produksi benih padi gogo yang bermutu  dan berkualitas dengan perkecambahan terbaik. Penelitian ini dilaksanakan di desa Kalukubula dan uji perkecambahan dilaksanakan di Laboratorium Ilmu dan Teknologi Benih. Penelitian ini dilaksanakan pada bulan Oktober 2019 sampai Februari 2020. Penelitian ini disusun menggunakan racangan acak kelompok (RAK) pola faktorial dua faktor, faktor pertama terdiri atas dua lokasi penyimpanan yaitu: P1= Dalam Ruangan, P2= Luar Ruangan, Sedangkan faktor kedua terdiri atas tiga waktu penyimpanan yaitu: W1=satu bulan dan W2= dua bulan, dan W3= tiga bulan, yang diulang sebanyak enam kali sehingga terdapat 36 unit percobaan dimana setiap unit percobaan terdapat 50 benih dan total benih yang digunakan ialah sebanyak 1.800 benih. Analisis data menggunakan uji Fisher dan dilanjutkan dengan menggunakan uji BNJ pada taraf 1%. Hasil penelitian menunjukkan hasil panen yang disimpan dalam ruangan selama 3 tiga bulan menghasilkan daya berkecambah (93,00%), waktu berkecambah (2,08 hari), potensi tumbuh maksimum (99,00%) dan persentase benih berjamur (1,33%).
EFEKTIVITAS KOMBINASI PUPUK ORGANIK PLUS DAN ANORGANIK BERBASIS LEISA TERHADAP PERTUMBUHAN DAN HASIL BAWANG MERAH
Authors: Fadillah Nurul , Sutariati Gusti Ayu Kade , Rakian Tresjia Corina
Published: February 2022

Penelitian ini bertujuan untuk mengkaji bagaimana pengaruh teknik LEISA terhadap pertumbuhan dan hasil tanaman bawang merah lokal di Kota Baubau, mengkaji bagaimana pengaruh teknik LEISA terhadap pertumbuhan dan hasil tanaman bawang merah lokal di Kota Baubau dan mengkaji perlakuan yang memberi pengaruh terbaik terhadap pertumbuhan dan hasil tanaman bawang merah lokal di Kota Baubau. Penelitian ini dilaksanakan di Laboratorium Lapangan Sekolah Menengah Kejuruan Negeri 5 (SMKN 5) Kecamatan Gonda Baru, Kota Baubau, Sulawesi Tenggara yang berlangsung pada bulan November 2020 sampai Februari 2021. Penelitian ini dilaksanakan menggunakan Rancangan Acak Kelompok Tunggal (RAK) dengan perlakuan Teknik LEISA yang terdiri atas 6 (enam) taraf yaitu P0=Tanpa aplikasi, P1=Pupuk Organik 5 ton ha-1, P2=Pupuk NPK Majemuk 250 kg ha-1, P3= Pupuk Organik 5 ton ha-1 + Pupuk NPK Majemuk 250 kg ha-1, P4= Pupuk Organik 5 ton ha-1 + 1/ 2 Pupuk NPK Majemuk  250 kg ha-1, P5= Pupuk Organik 5 ton ha-1 + 1/ 4 Pupuk NPK Majemuk 250 kg ha-1 .Dengan demikian setiap perlakuan diulang 3 kali, sehingga terdapat 18 unit percobaan. Variabel yang diamati yaitu tinggi tanaman, jumlah daun, jumlah anakan, berat kering, jumlah umbi, berat umbi dan produksi per petak. Data hasil pengamatan dianalisis ragam dan data yang menunjukkan pengaruh nyata atau sangat nyata dilanjutkan dengan Uji Jarak Berganda Duncan (UJBD) pada taraf nyata α = 0,05.  Hasil penelitian menunjukkan bahwa LEISA mampu meningkatkan pertumbuhan dan hasil tanaman bawang merah terutama pada  variabel jumlah daun, jumlah anakan, bobot kering tanaman, jumlah umbi, berat umbi dan produksi per petak. Perlakuan sistem LEISA terbaik diperoleh pada perlakuan Pupuk Organik 5 ton ha-1 + Pupuk NPK Majemuk 250 kg ha-1 (P3) dengan  dibandingkan dengan kontrol.
Zakat, Infaq, and Shadaqah
Authors: Abbas Ahmad , Hannani Hannani
Published: February 2022

Accounting for reporting zakat, infaq, and shadaqah has been standardized, but LAZISNU Parepare is still simply providing bookkeeping based on income and expenses made as the balance. This research aims to identify the bookkeeping of LAZISNU and assists to practice the financial statements in accordance with the accounting standard of PSAK 109. A qualitative type was used in this research with the case study approach. The result of this research found that the practice of accounting in LAZISNU has simple bookkeeping only showing cash receipt and disbursement. This research further assists to prepare financial statements of LAZISNU Parepare and it has successfully been presented into financial position statement (balance sheet), changes in funds, changes in assets under management, cash flow statement, and summary of accounting policies. By disclosing the financial statements, LAZISNU can be more accountable and transparent to stakeholders particularly Muzakki dan government.
Depiction of Security Issues in Selected Yorùbá Proverbs
Authors: AROWOSEGBE Deborah Bamidele
Published: February 2022

Yorùbá proverbs are a part of the wisdom lore of the Yorùbá race. The Yorùbá people value proverbs highly. They try to look for solutions to their problems in their proverbs. The prevailing criminal in Nigeria create an atmosphere of insecurity in the country. The question this paper intends to answer is whether the use of Yoruba proverbs can bring insecurity in Yorùbá land under control? To answer this question, adopting the sociology of literature, this study examined thirty security related Yorùbá proverbs collected through personal observations and published texts on Yorùbá proverbs. Our findings showed that false assumptions, bad company, and lack of foresight can bring about insecurity, while having foresight and making joint efforts can strengthen the security of Yorùbá land. The paper concludes that Yorùbá proverbs relevant to security matters can reduce the problems of insecurity in Yorùbá land if their teachings are utilised to guide them appropriately.

Keywords: insecurity, proverbs, vigilance, wisdom
Interfaz computacional móvil con realidad aumentada como asistente para personas con discapacidad visual
Authors: Sánchez Orea Alfonso , Navarro Guerrero María de los Ángeles , Lagunes Barradas Virginia , Ochoa Rivera Carlos Alberto
Published: February 2022

Conseguir la incorporación de las personas con discapacidad visual a cualquier ámbito laboral, cultural o meramente social, específicamente a través del uso de las tecnologías de la información (TIC), es una obligación colectiva, por tal motivo, desde el área de las TIC, se empiezan a desarrollar interfaces específicamente diseñadas para este tipo de usuarios, permitiendo así, conseguir la independencia de los mismos en cuanto a su ubicación y orientación en el espacio, partiendo del conocimiento de sus limitaciones y habilidades y de la idea de desarrollar nuevas aplicaciones con alto grado de usabilidad. La utilización de tecnología móvil como medio para proporcionar información del entorno, así como las instrucciones vía audio, generará una mayor independencia a las personas con alguna discapacidad visual en cuanto a su movilidad.

Achieving the incorporation of people with visual disabilities into any work, cultural or purely social sphere, specifically through the use of information technologies (ICT), is a collective obligation, for this reason, from the area of ICT, begin to develop interfaces specifically designed for this type of users, thus allowing them to achieve their independence in terms of location and orientation in space, based on knowledge of their limitations and abilities and the idea of developing new applications with high degree of usability. The use of mobile technology as a means to provide information on the environment, as well as instructions via audio, will generate greater independence for people with a visual disability in terms of mobility.
AES como Estándar Internacional de Cifrado
Authors: García Belmont Reyna , Lotzin Rendón Gabriela , Cabrera Hernández Luis , Puente Pérez Ma. del Consuelo , Méndez Lemus Ofelia Verónica
Published: February 2022

Con el uso del internet hoy en día estamos inmersos en la sociedad de la información y tecnología, manteniéndonos siempre conectados y al mismo tiempo expuestos, en ese sentido la seguridad de la información busca proteger la información, la seguridad informática no sólo busca proteger la información, sino también la infraestructura que la rodea (como procesos y sistemas) y finalmente se encuentra la ciberseguridad que abarca la infraestructura de una organización y/ó país; teniendo con esto tres áreas de vital importancia enfocadas a la prevención e implementación correcta de controles que permitan contrarrestar las amenazas. Lo anterior nos lleva a la creación de una aplicación que se pueda incluir en sistemas proporcionando aspectos de seguridad basados en el estándar AES, involucrando procedimientos formales de un protocolo criptográfico. Con este trabajo se busca identificar la tendencia ofrecida por los sistemas criptográficos frente al uso de herramientas convencionales.
Sistema Integral para la gestión de información académica en educación superior
Authors: Carreño León M.A. , Sandoval Bringas J.A. , Durán Encinas I.
Published: February 2022

En el ámbito administrativo, las Tecnologías de la Información (TIC) en las universidades han permitido la automatización de procesos, facilitando la organización y la obtención de información para la toma de decisiones. Por otro lado, para asegurar la calidad y el mejoramiento continuo de sus programas educativos, es necesario someterse a un proceso de evaluación a través de un organismo acreditador. En el presente trabajo, se presenta el diseño y la implementación de un sistema integral que permite concentrar la información de diferentes procesos interrelacionados, para facilitar la gestión de la información académica, permitiendo la toma de decisiones mediante la generación de indicadores y evidencias necesarias para apoyar los procesos de acreditación.

In the administrative area, Information Technology (ICT) has allowed the automation of processes, facilitating the organization and obtaining information for decision making. On the other hand, to ensure the quality and continuous improvement of their educational programs, it is necessary to undergo an evaluation process through an accrediting body. In the present work, the presentation of the design and the implementation of an integral system that allows to concentrate the information of different interrelated processes, to facilitate the management of the academic information, to allow the decision making by means of the generation of indicators and evidences necessary to support the accreditation processes.
МЕХАНІЗМ ПУБЛІЧНОГО АДМІНІСТРУВАННЯ У СФЕРІ РОЗБУДОВИ СОЦІАЛЬНОЇ ВІДПОВІДАЛЬНОСТІ БІЗНЕСУ
Authors: ЧЕРВІНСЬКА Любов , ЧЕРВІНСЬКА Тетяна
Published: February 2022

Проблематика менеджменту в контексті екологічної соціальної відповідальності сьогодні в центрі уваги багатьох країн і світової спільноти. Її значимість збільшується внаслідок процесів глобалізації, зростаючого впливу діяльності бізнес-структур на довкілля, небезпечності зовнішнього середовища підприємств і регіонів тощо. В менеджменті організацій набули поширення інноваційні практики етики бізнесу, складовою яких є екологічна відповідальність. Метою статті є оцінка теоретичних і практичних аспектів інноваційних практик менеджменту в контексті екологічної соціальної відповідальності бізнесу в країні і за рубежем і визначення напрямів поширення їх використання. Задля цього проаналізовано апробовані інноваційні українські практики та зарубіжний досвід екологічної відповідальності бізнесу, запропоновано ефективні підходи з поширення екологічних ініціатив в діяльності бізнесу, що стосується впровадження інновацій щодо модифікації продукції, використання основних критеріїв, ознак і мотивів екологічної відповідальності компаній, виявлення впливу екологічної складової брендів, застосування екологічно орієнтованого кредитування тощо.
ПУБЛІЧНЕ УПРАВЛІННЯ РОЗВИТКОМ ВИЩОЇ ОСВІТИ: МЕХАНІЗМ МІЖНАРОДНИХ ПРОЄКТІВ І ПРОГРАМ
Authors: ГАЛИЦЬКА Наталія
Published: February 2022

У статті визначено перспективи розвитку вищої освіти на міжнародному рівні. В Європі та світі існує багато можливостей для ЗВО, а саме для здобувачів вищої освіти та науково-педагогічних працівників. Вітчизняним ЗВО бракує взаємодії з міжнародними ЗВО. Встановлено, що формами міжнародної взаємодії українських закладів вищої освіти з міжнародними є подвійне дипломування, вивчення іноземних мов, участь у міжнародних програмах та проектах, а також здійснення наукової діяльності у партнерстві із закордонними ЗВО, що, зокрема, передбачає видання спільних монографій, проведення круглих столів, конференцій, семінарів, лекцій, двосторонню публікацію статей, роботу над науковим проектом і співпрацю із бізнесом – реалії сьогодення, які потрібно враховувати, щоб бути конкурентоздатними за відповідними показниками у міжнародному вимірі. Обгрунтовано, що значний вплив на розвиток вищої освіти має системна участь у міжнародних програмах та проектах. Наразі така участь України носить несистемний, фрагментарний характер, що негативно впливає на інтеграційні процеси, конкурентоздатність вітчизняної освіти та імідж українських ЗВО на світовій арені.
Our experience in developing and operating the Airway Intervention Registry for Recurrent Respiratory Papillomatosis (AIR-RRP): national data collection
Authors: Sims Andrew , Keltie Kim , Belilios Emma , Burn Julie , Brown Liz , Jackson Aaron , Powell Steven , Jones Sue , Donne Adam
Published: February 2022

Recurrent respiratory papillomatosis (RRP) is characterised by benign wart-like growths in the respiratory tract caused by the human papillomavirus (HPV). These warts vary in size and grow quickly, causing voice changes and airway obstruction. Whilst the condition is rare, RRP is more common and aggressive in children. There is currently no curative treatment for HPV, therefore RRP is managed by maintaining a safe airway and a serviceable voice by repeated surgery to remove the growths.

A lack of specific diagnostic codes prevents reliable case ascertainment of RRP from routine administrative databases such as Hospital Episode Statistics. To determine RRP burden in the UK, we conducted a cross-sectional survey of ENT consultants; 283 responded, identifying 918 RRP patients, half of whom received surgical intervention for RRP in the previous 12 months with 16 different interventions reported.

Randomised controlled trials for RRP interventions are difficult due to the rarity of the disease, variation in severity and progression and non-standard care across the NHS. Consequently, there is a lack of definitive efficacy and safety evidence. The only national guidance for RRP interventions is “Radiofrequency cold ablation for respiratory papillomatosis” (NICE IPG434, 2017) which recommended further data collection due to lack of evidence. However, due to the wide variation in RRP management across the NHS, clinical opinion favoured that any data collection should include a comparison of safety and efficacy of all RRP interventions in order to advise which improved patient outcomes and quality of life.

To address lack of evidence, and inform the future care of RRP patients, we developed a registry and used it to collect real-world data from patients receiving treatment for RRP in NHS hospitals across the UK. The purpose of this paper is to share lessons learned from this national data collection exercise to inform future clinical registry development.
Exoticism, Exchange, and Early Indigenous-Colonial Relations in the 15th to 16th Century Caribbean
Authors: Dua Akshay
Published: February 2022

The initial interactions between Indigenous groups and European colonists across the Caribbean were largely shaped by pre-existingsociocultural conditions. The central importance of exchange for social construction and the concomitantly high value placed upon foreign material was common to many Native societies. This played in contrast to European understandings of exchange, which was far more focused on economic gain and competitive bargaining. The role assigned to exchange and the foreign in Indigenous and European societies guided their perceptions of each other and respective goals in interaction. Native systems were well entrenched throughout the regional networks of trade and culture in the Caribbean, and so colonists entered into a world fundamentally defined by such systems. European imperial views permitted them to exploit these systems, twist- ing Indigenous exaltation of intercultural trade into a tool for attempted oppres- sion, subversion, and assimilation. Nevertheless, colonists were unable to under- mine core structures, even if they appropriated them for the creation of new hierar- chies and dehumanization of Natives. These structures prevailed even as coloniza- tion grew more pervasive and degenerative.
INTEGRATION OF ENVIRONMENTAL EDUCATION (EE) IN TEACHER EDUCATION PROGRAMS: TOWARD SUSTAINABLE CURRICULUM GREENING
Authors: Corpuz Alma M. , San Andres Teody C. , Lagasca Julieta M.
Published: February 2022

Environmental education (EE) is vital in addressing global environmental problems. Educational institutions are integrating EE into their curricula, but studies indicated the need for its intensification. This mixed method study assessed the integration of EE in Teacher Education Programs (TEPs) in Region III, Philippines. Respondents were 10 program deans,10 chairs, 171 teachers, and 344 students. Data were gathered using validated questionnaires. Findings revealed that the New Teacher Education Curriculum (NTEC) integrated EE in program outcomes and performance indicators; in mandated courses -Physical Education (PE) and National Service Training Program (NSTP); and in Science Technology and Society (STS), a General Education (GE) course. Likewise, teachers integrated EE in their lessons and in community extension programs. Seminars/webinars included environmental care and promoted environmental awareness in social media. As to support for EE integration, administrative, physical facilities and financial support were provided. On student outcomes, positive findings were shown on attitude towards environment care, but application of knowledge and skills needs improvement. Students’ knowledge was significantly correlated to attitude (Pearson’s r value is.593 and p value <.05) as well as skills acquisition and attitude (Pearson’s r value is .647 and p value <.05). Teachers’ challenges in the EE integration included inadequate environmental knowledge and lack of time to lead students in environmental action. The study concludes that EE is integrated into the TEPs but the outcomes on the learners’ knowledge and skills acquisition still need strengthening. Also, EE should be integrated in professional education courses, not only in GE and mandated courses.
Keywords: assessment, integration of environmental education, mixed method, sustainable curriculum greening, teacher education programs
Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia
Authors: Tuval Amos , Brilon Yardena , Azogy Hadas , Moskovitz Yoni , Leshkowitz Dena , Salame Tomer M. , Minden Mark D. , Tal Perry , Rotter Varda , Oren Moshe , Kaushansky Nathali , Shlush Liran I.
Published: February 2022

Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemoresistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hematopoietic stem/progenitor cells (preL-HSPC) and lead to chemoresistance. Many of these mutations cause a conformational change and some of them were shown to enhance self-renewal capacity of preL-HSPC. Intriguingly, a misfolded P53 was described in AML blasts that do not harbor mutations in TP53, emphasizing the dynamic equilibrium between wild-type (WT) and “pseudo-mutant” conformations of P53. By combining single cell analyses and P53 conformation-specific monoclonal antibodies we studied preL-HSPC from primary human DNMT3A-mutated AML samples. We found that while leukemic blasts express mainly the WT conformation, in preL-HSPC the pseudo-mutant conformation is the dominant. HSPC from non-leukemic samples expressed both conformations to a similar extent. In a mouse model we found a small subset of HSPC with a dominant pseudo-mutant P53. This subpopulation was significantly larger among DNMT3AR882H-mutated HSPC, suggesting that while a pre-leukemic mutation can predispose for P53 misfolding, additional factors are involved as well. Treatment with a short peptide that can shift the dynamic equilibrium favoring the WT conformation of P53, specifically eliminated preL-HSPC that had dysfunctional canonical P53 pathway activity as reflected by single cell RNA sequencing. Our observations shed light upon a possible targetable P53 dysfunction in human preL-HSPC carrying DNMT3A mutations. This opens new avenues for leukemia prevention.
Regression Analysis in Development of Method for Isolation and Quantitative Determination of Water-soluble Polysaccharides from Sunflower Roots of One-year-old
Authors: Dyakova N. A.
Published: February 2022

Introduction. The roots of one-year-old sunflower (Helianthus annuus L.) are mainly wastes of agricultural enterprises when cultivating this crop. At the same time, they differ in a rich chemical composition and contain water-soluble polysaccharides, the base of which is inulin.

Aim. The aim of this study is to select optimal parameters of ultrasonic extraction of water-soluble polysaccharides from sunflower roots of oneyear old based on regression analysis.

Materials and methods. For the experiment, raw materials purchased from one of the pharmacies in the city of Voronezh were used. A sample of raw materials (1.0 grams) was placed in an ultrasonic bath Grad 40-35, which allows maintaining the necessary temperature and frequency of ultrasound with a given duration of time. Then, 10 (15 or 20) ml of purified water purified from impurities at a temperature of 60 °C to 80 °C was measured with a measuring flask and extracted from 10 to 20 minutes with a multiplicity of 1 to 3, and after each of the multiple studies, the same raw material was further filtered with a new solvent.

Results and discussion. The initial conditions and the data obtained during the experiments made it possible to present the regression model in the form of a linear multiple regression equation, which can be used with sufficient accuracy in prediction and analysis. The adequacy of the model was confirmed by testing hypotheses against Pearson's χ2 criterion. The correlation coefficient derived from the values of the regression coefficient and the mean square deviation was used in determining the tightness of the overall relationship between the source and the obtained data. In addition, a detailed study of a sample of those variables whose priority was not clearly expressed was carried out by processing when fixing their values.

Conclusion. The most important conditions for extraction of the roots of sunflower of a one-year old should be considered: extraction temperature equal to 80 °C; extraction multiplicity equal to 3; an ultrasound frequency of 35 kHz; Note here that raw material grinding can vary from 0.5 mm to 2 mm, extraction time can range from 15 min to 20 min, ratio of raw material and extractant can vary from 1 g per 10 ml to 1 g per 15 ml.
Pharmacokinetics Study of the Long-acting Antiarrhythmic Drug of Lappaconitine Hydrobromide (Allaforte®, JSC "Pharmcenter VILAR", Russia)
Authors: Archakova O. A. , Bagaeva N. S. , Komarov T. N. , Rogov A. V. , Shchelgacheva D. S. , Suvorova A. V. , Karnakova P. K. , Karpova P. A. , Shohin I. E.
Published: February 2022

Introduction.Allaforte® (JSC "Pharmcenter VILAR", Russia) is an antiarrhythmic long-acting drug. The dosage form of the drug Allaforte® provides a decrease in the frequency of taking the drug and also reduces the risk of side effects. It is relevant when taking antiarrhythmic drugs of the IC class. However, the pharmacokinetics of this drug has not been studied on humans. Therefore, it is important to fully study the pharmacokinetics to ensure the maximum efficacy and safety of arrhythmia therapy.

Aim.The aim is pharmacokinetics study of long-acting antiarrhythmic drug Allaforte® (JSC "Pharmcenter VILAR", Russia), 25 mg. Materials and methods. Concentration of lappaconitine and its active metabolite N-desacetyllappaconitine in human plasma determinates by high performance liquid chromatography with tandem mass-spectrometry. Pharmacokinetic parameters calculated by R Project 3.5.1 software (package «bear», version 2.8.3-2), originally created by Hsin-ya Lee and Yung-jin Lee, Taiwan.

Results and discussion.Pharmacokinetic parameters of lappaconitine and N-desacetyllappaconitine were calculated. Averaged pharmacokinetic profiles (in linear and semi-log scale) of lappaconitine and N-desacetyllappaconitine after single administration under fasting were built. The means of the maximum concentrations (Cmax) determined in the blood plasma of volunteers after single administration Allaforte® are 5.09 ± 4.07 ng/ml for lappaconitine and 11.66 ± 6.21 ng/ml for N-deacetyllappaconitine (Mean ± SD). The peak time of the maximum concentrations (Tmax) is 4.43 ± 3.54 hours for lappaconitine and 4.04 ± 2.18 hours for N-deacetyllappaconitine. The means of the areas under the curve plasma concentration – time from 0 to 48 hours (AUC0-t) and under the curve plasma concentration–time from zero to infinity (AUC0-∞) of Allaforte® is 42.96 ± 34.48 ng ∙ h/ml and 71.24 ± 43.20 ng ∙ h/ml for lappaconitine; 167.42 ± 114.41 ng ∙ h/ml and 189.42 ± 115.20 ng ∙ h/ml for N-deacetyllappaconitine. Allaforte® was eliminated from blood plasma with means of terminal half-life (T1/2) 8.45 ± 5.10 hours for lappaconitine and 9.04 ± 2.57 hours for N-deacetyllappaconitine.

Conclusion.Pharmacokinetics study of long-acting antiarrhythmic drug Allaforte® (JSC "Pharmcenter VILAR", Russia) after single administration was researched. Results of the study allows to conduct an effective therapy of arrhythmia by study drug and minimize side effects.
Organization of Hygienic Monitoring of Working Area Air Pollution by Particulates in Pharmaceutical Industries (Review)
Authors: Pozharnov I. A. , Simakov A. S. , Shatilina A. A. , Ramenskaya G. V.
Published: February 2022

Introduction.The use of highly active substances of various origins in the pharmaceutical industry exposes employees working directly with active pharmaceutical substances (APS) in manufacturing facilities to risks. Although pharmaceutical companies follow occupational safety requirements, such as the use of personal protective equipment (PPE), the manipulation of highly toxic substances in specially dedicated indoor facilities, etc., the impact of risk factors on the health of workers must be regularly assessed and monitored. Therefore, hygienic monitoring of working area air is obligatory in activity of pharmaceutical enterprises. A range of normative documents (orders, State standards, methodological guidelines, manuals) are currently in force in the Russian Federation defining uniform requirements for the organization and monitoring of working area air pollution by particulates. At the same time, the development of appropriate adjusted methodologies for determining the content of a specific substance in working area air is a mandatory requirement for all manufacturing enterprise by legislation.

Text.The article provides a review of the Russian regulatory framework and relevant literature sources relating to the order of organization and performance of hygienic monitoring of working area air, including foreign ones. On the basis of a comparative analysis of the aforementioned literature completed in order to reveal common provisions, the comprehensive methodology for the monitoring of the content of harmful substances in the working area air at pharmaceutical enterprises is described.

Conclusion.As a result of a comparative analysis of the literature reviewed, a detailed comprehensive methodology for the monitoring of the content of harmful substances in the working area air is presented, including a description of the equipment and materials required for sampling, sampling strategies, recommendations for monitoring protocols, procedures for storage and transport of samples, and procedure for sample analysis. This article may serve as a possible reference for pharmaceutical enterprises to develop individual methodologies for determining the concentration of a specific substances in working area air.
ROBÔ DE SOLDA DE CHAPISCO DE MOENDA
Authors: Giorgetti Willian Carlos , Bovério Maria Aparecida , Silva Dejaime Pereira da
Published: February 2022

Esse artigo apresenta um trabalho que foi realizado sobre processos robotizados, ou seja, tarefas que antes eram feitas exclusivamente pelo homem e que, hoje, são realizadas por máquinas automatizadas. Foi considerado como base o processo de soldagem em uma das áreas da indústria sucroalcoleira, no que se refere ao robô de solda de chapisco de moenda. Ele executa a tarefa realizada pelo homem em locais com ambientes degradantes e perigosos. Como metodologia foi realizado um estudo de caso em um robô de chapisco da empresa F. Mecal Mecânica e Caldeiraria Eireli. Ele utiliza arame de solda ao invés de eletrodo revestido, pois tem praticamente o mesmo efeito do eletrodo revestido para o chapisco, com uma pequena desvantagem, por causa de seu preço um pouco acima do eletrodo revestido, mas sua aplicação é simples e eficiente. O robô de chapisco de moenda tem por finalidade agregar material entre os frisos para que a moenda tenha maior aderência e tração na moagem de cana. Como resultados, foi possível verificar que, além de realizar um chapisco uniforme, sem falhas, e com menor tempo, ele não pula frisos, pois está programado com o número de frisos de cada rolo da moenda, podendo ser alterado pelo operador, de acordo com cada tipo de moenda. Conclui-se que o ser humano que trabalhava como chapiscador de moenda passa a se tronar operador de robô, um trabalho bem mais leve fácil e com remuneração superior e, por isso, há vantagens tanto para a empresa como para o funcionário.
Analisis Kinerja Keuangan Berbasis Akrual Atas Laporan Keuangan Pemerintah Daerah Kabupaten Konawe
Authors: Mas’ud Arifuddin , Hadisantoso Erwin , Relis Relis
Published: February 2022

The purpose or this study was to determine the accrual-based financial performance on financial statements of the Konawe District government. The data used in this study is the Konawe District Government financial report data for the 2015-2016 fiscal year. The data collection techniques are library research and interviews. This research method is descriptive analysis, using several financial ratios, and regional financial dependence ratios.The results of this study are the financial performance of the Konawe District Government in 2015 and 2016 in terms of liquidity ratios, solvency ratios and debt ratios which have shown good performance despite the decline in all ratios in 2016 but the value is still whit in safe limits, but ther are some of the ratios that describe the performance of Konawe District government are not good, such as regional financial independence ratios that are between 0-25% classified as having an instructive relationship pattern which means the role of the central government is more dominant than the independence of local governments (regions that are not able to carry out blood autonomy financially). Regional financial dependency ratios are on an interval skale, 10.01-20.00%. This means that the Regional Revenue has a considerable dependency to finance direct expenditure and the Konawe District Government is still dependent on sources of financial revenue from central and provincial government transfers.
Evaluasi Penerapan Sistem Pengendalian Intern Pemerintah Dalam Meningkatkan Penerimaan Pajak Daerah Pada Badan Pengelola Pajak dan Retribusi Daerah Kabupaten Kolaka
Authors: Satira Yusuf Satira , Aswati Wa Ode , Yulianti Yulianti
Published: February 2022

This study aims to evaluate the internal control system which is guided by government regulation number 60 of 2008 concerning the government's internal control system and are to investigate the factors which influence the realization of revenue on the land and building taxes in district kolaka. This research was conducted at the Tax Management Agency and Regional Retribution of the district kolaka. The data analysis method used in this research is descriptive analysis method. The type of data used in this study is qualitative, qualitative data in the form of questionnaires. The method of data collection uses questionnaire and interview methods. The results of this study indicate that the percentage of the internal control system is categorized as adequate with a value of 80.19%. The percentage obtained by each indicator, namely for the Control Indicator Environment is categorized as adequate with a value of 64,24%. The Risk Assessment Indicator is categorized as adequate with a value of 66,56%. The Indicator of Control Activities is categorized as very adequate with a value of 97,65%. Information and Communication indicators are categorized as very adequate with a value of 81,24%. Monitoring indicators are categorized as adequate with a value of 73,12%. Overall, the five indicators show a adequate category, which is 80,19%. The percentage of the local tax admissions system is categorized very according to the value of 100,00%. The percentage obtained by each indicator, namely for the Registration & Data Indicator is categorized as very suitable with a value of 100,00%. Determination indicators & objections are categorized as very suitable with a value of 100.00%. Billing Indicators are categorized as very suitable with a value of 100.00%. Overall, the three indicators show very suitable categories, namely 100,00%. The lack of realization of land and building taxes in district kolaka is caused by several external factors, namely: (1) Lack of public awareness. (2) Taxpayers do not reside in the tax object. (3) Taxpayers ' home tenants or only while occupying tax objects. (4) Taxpayers are not recognised. (5) The Taxpayer name error in Notification of Tax Due (L&B Tax). (6) The Tax object address does not match the actual condition.