bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Reactivity of 6,8-Dibromo-2-ethyl-4H-benzo[d][1,3]oxazin-4-one Towards Nucleophiles and Electrophiles and Their Anticancer Activity
Authors: El-hashash Maher A. , Ali Amira T. , Hussein Rasha A. , El-Sayed Wael M.
Published: February 2019

Background:

The genetic heterogeneity of tumor cells and the development of therapy-resistant
cancer cells in addition to the high cost necessitate the continuous development of novel targeted therapies.

Methods:

In this regard, 14 novel benzoxazinone derivatives were synthesized and examined for anticancer
activity against two human epithelial cancer cell lines; breast MCF-7 and liver HepG2 cells. 6,8-Dibromo-2-
ethyl-4H-benzo[d][1,3]oxazin-4-one was subjected to react with nitrogen nucleophiles to afford quinazolinone
derivatives and other related moieties (3-12). Benzoxazinone 2 responds to attack with oxygen nucleophile such
as ethanol to give ethyl benzoate derivative 13. The reaction of benzoxazinone 2 with carbon electrophile such
as benzaldehyde derivatives afforded benzoxazinone derivatives 14a and 14b.The structure of the prepared
compounds was confirmed with spectroscopic tools including IR, 1H-NMR, and 13C-NMR.

Results:

Derivatives 3, 9, 12, 13, and 14b exhibited high antiproliferative activity and were selective against
cancer cells showing no toxicity in normal fibroblasts. Derivative 3 with NH-CO group in quinazolinone ring
was effective only against breast cells, while derivative 12 with NH-CO group in imidazole moiety was only
effective against liver cells probably through arresting cell cycle and enabling repair mechanisms. The other
derivatives (9, 13, and 14b) had broader antiproliferative activity against both cell lines. These derivatives enhance
the expression of the p53 and caspases 9 and 3 to varying degrees in both cell lines. Derivative 14b
caused the highest induction in the investigated genes and was the only derivative to inhibit the EGFR activity.

Conclusions:

The unique features about derivative 14b could be attributed to its high lipophilicity, high carbon
content, or its extended conjugation through planar aromatic system. More investigations are required to identify
the lead compound(s) in animal models.
Alterations of RNA Metabolism by Proteomic Analysis of Breast Cancer Cells Exposed to Marycin: A New Optically Active Porphyrin
Authors: Taverna Elena , De Bortoli Maida , Maffioli Elisa , Corno Cristina , Ciusani Emilio , Trivulzio Silvio , Pinelli Arnaldo , Tedeschi Gabriella , Perego Paola , Bongarzone Italia
Published: February 2019

Objective:

Marycin is a porphyrin-type compound synthetically modified to spontaneously
release fluorescence. This study is aimed at understanding possible mechanisms that could account for
the antiproliferative effects observed in marycin. A proteomic approach was used to identify molecular
effects. The proteome of proliferating MDA-MB-231 breast cancer cells was compared with that of
marycin-treated cells.

Methods:

Label-free proteomic analysis by liquid chromatography coupled with tandem mass spectrometry
(LC-MS/MS) was used to reveal changes in protein expression and fluorescence microscopy
and flow cytometry were used to detect subcellular organelle dysfunctions.

Results:

The bioinformatic analysis indicated an enhancement of the expression of proteins remodeling
RNA splicing and more in general, of RNA metabolism. Marycin did not localize into the mitochondria
and did not produce a dramatic increase of ROS levels in MDA-MB-231 cells. Marycin stained organelles
probably peroxisomes.

Conclusions:

The results could support the possibility that the peroxisomes are involved in cell response
to marycin.
Application of DECAF and BAP-65 to Predict the In-Hospital Mortality of Acute Exacerbation
of COPD in SRMSIMS
Authors: Agrawal Anurag , Jain Shruti , Singh Lalit , Tandon Rajeev
Published: February 2019

Introduction: Hospitalisation due to acute exacerbations of
COPD (AECOPD) is common, and subsequent mortality high.
The dyspnoea, eosinopenia, consolidation, acidemia and atrial
fibrillation (DECAF) and BAP 65 score was derived for accurate
prediction of mortality and risk stratification to inform patient
care. We aimed to validate these scores and to compare them
in predicting hospital mortality in AECOPD.
Material and Methods: 106 patients of AECOPD, admitted
during 6 months period were scored at admission using all
two scores and their ability to predict in-hospital mortality were
analyzed.
Results: On receiver-operator characteristic curve analysis, the
area under the curve for prediction of in-hospital mortality was
0.791 and 0.885, respectively, for DECAF and BAP-65 scores.
Thus, among the two scoring systems, BAP-65 had a maximum
area under curve while DECAF had a minimum area under the
curve. Sensitivity and specificity values for prediction of in-hospital
mortality were 83.3 and 54.3% for DECAF and 83.3 and 84.0%
for BAP-65. Thus, BAP-65 was the better predictor with adequate
sensitivity and specificity for the in-hospital mortality.
Conclusion: BAP-65 was most effective in the prediction of
in-hospital mortality.
A Comparative Study to Evaluate C-Reactive Protein and
Procalcitonin as a Marker of Bacterial Infection in Patients with
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Authors: Agrawal Nipun , Jain Anshul , Singh Lalit , Jain Abhishek
Published: February 2019

Introduction: Exacerbations of chronic obstructive pulmonary
disease (COPD) can be precipitated by several factors. The
most common causes appear to be respiratory tract infections.
The overuse of antibiotics is common and accelerates
the development of drug resistance and hospital-acquired
infections. In some recent studies, both C-reactive proteins
(CRP), as well as procalcitonin (PCT) levels, have been shown
to be useful in differentiating bacterial etiology of exacerbations
and thus helping in guiding the treatment as well as in prediction
of outcome. This study aims to evaluate the sensitivity and
specificity of CRP and procalcitonin as a marker of bacterial
infection in patients with acute exacerbation of COPD.
Material and Methods: A total of 50 patients from patients of
COPD with acute exacerbation attending/admitted to pulmonary
OPD/IPD were included in the study, excluding those below
40 years old or presenting with acute breathlessness due
to comorbid conditions. Demographic information, relevant
clinical data, and lab investigations were recorded from all
patients, including C-reactive protein and procalcitonin, on
admission following which the patients have started antibiotics
as per guidelines. Reassessment of S. procalcitonin and CRP
was done on the 3rd and 7th day of hospitalization. Receiveroperating
characteristic (ROC) curve was applied to compare
sensitivity and specificity.
Results: Sputum culture was found positive in 27 (54%)
patients. At all the three intervals, CRP levels had ROC area
under curve (ROC AUC) values above 0.70. The area under
curve value was maximum on day 3. For PCT, the area under
curve values was > 0.8 on day 1 and 3, but on day 7 this value
was only 0.624. On evaluating the correlation between S.
C-reactive protein and PCT levels, a mild positive and significant
correlation was observed at day 1 and 7 intervals, whereas
on day 3 a moderate positive and significant correlation was
observed between the two markers.
Conclusion: The CRP is a good marker when tested early and
late, while PCT is better when tested early.
Optimización de las condiciones de producción de cápsulas con microestacas para aumentar el tiempo de almacenamiento de la planta medicinal mexicana Castilleja tenuiflora (Orobanchaceae)
Authors: León Romero Yatzil , Trejo Espino José Luis , Salcedo-Morales Guadalupe , Trejo-Tapia Gabriela , Evangelista Lozano Silvia
Published: February 2019

Antecedentes y Objetivos: Castilleja tenuiflora es una de las plantas mexicanas, silvestres y medicinales cultivadas in vitro que presentan actividad biológica antiinflamatoria y antiulcerogénica. La encapsulación de microestacas es una opción para propagar y prolongar el almacenamiento de esta planta. El objetivo de este estudio fue establecer un método para la encapsulación y conservación de microestacas de C. tenuiflora sin afectar el contenido de sus compuestos.Métodos: Las cápsulas fueron elaboradas con alginato de sodio en complejo con cloruro de calcio dihidratado como matriz y microestacas de tejido proveniente de plántulas cultivadas in vitro. Se probaron diferentes concentraciones y tiempos de polimerización, así como diferentes tiempos de almacenamiento y temperatura, para posteriormente analizar los metabolitos mayoritarios de los extractos metanólicos mediante cromatografía (HPLC) de las plantas resultantes.Resultados clave: La combinación para la producción de cápsulas con microestacas es alginato de sodio al 3% y cloruro de calcio dihidratado al 50 mM, con 25 minutos de polimerización. Las plántulas derivadas de semillas sintéticas, almacenadas por 100 días presentaron los mismos compuestos que las plantas donantes.Conclusiones: La encapsulación de microestacas de C. tenuiflora con alginato de sodio y cloruro de calcio dihidratado permite el almacenamiento del material vegetal y se mantienen sus compuestos principales, por lo que es una alternativa para mantener el genotipo de plantas elite y contrarrestar el saqueo de plantas silvestres.
Fraud Detection Protocol for Web-Based Research Among Men Who Have Sex With Men: Development and Descriptive Evaluation (Preprint)
Authors: Ballard April M , Cardwell Trey , Young April M
Published: February 2019

BACKGROUND

Internet is becoming an increasingly common tool for survey research, particularly among “hidden” or vulnerable populations, such as men who have sex with men (MSM). Web-based research has many advantages for participants and researchers, but fraud can present a significant threat to data integrity.

OBJECTIVE

The purpose of this analysis was to evaluate fraud detection strategies in a Web-based survey of young MSM and describe new protocols to improve fraud detection in Web-based survey research.

METHODS

This study involved a cross-sectional Web-based survey that examined individual- and network-level risk factors for HIV transmission and substance use among young MSM residing in 15 counties in Central Kentucky. Each survey entry, which was at least 50% complete, was evaluated by the study staff for fraud using an algorithm involving 8 criteria based on a combination of geolocation data, survey data, and personal information. Entries were classified as fraudulent, potentially fraudulent, or valid. Descriptive analyses were performed to describe each fraud detection criterion among entries.

RESULTS

Of the 414 survey entries, the final categorization resulted in 119 (28.7%) entries identified as fraud, 42 (10.1%) as potential fraud, and 253 (61.1%) as valid. Geolocation outside of the study area (164/414, 39.6%) was the most frequently violated criterion. However, 33.3% (82/246) of the entries that had ineligible geolocations belonged to participants who were in eligible locations (as verified by their request to mail payment to an address within the study area or participation at a local event). The second most frequently violated criterion was an invalid phone number (94/414, 22.7%), followed by mismatching names within an entry (43/414, 10.4%) and unusual email addresses (37/414, 8.9%). Less than 5% (18/414) of the entries had some combination of personal information items matching that of a previous entry.

CONCLUSIONS

This study suggests that researchers conducting Web-based surveys of MSM should be vigilant about the potential for fraud. Researchers should have a fraud detection algorithm in place prior to data collection and should not rely on the Internet Protocol (IP) address or geolocation alone, but should rather use a combination of indicators.
Protocol for the Development of a Behavioral Family Lifestyle Intervention Supported by Mobile Health to Improve Weight Self-Management in Children With Asthma and Obesity (Preprint)
Authors: Fedele David , Lucero Robert , Janicke David , Abu-Hasan Mutasim , McQuaid Elizabeth , Moon Jon , Fidler Andrea , Wallace-Farquharson Tanya , Lindberg David
Published: February 2019

BACKGROUND

Asthma is the most common chronic childhood illness and is a leading cause of emergency department visits in the United States. Obesity increases the risk of poor health outcomes, reduced quality of life, and increased health care expenditures among youth with asthma. Weight loss is crucial for improving asthma outcomes in children with obesity. Our study team developed the Childhood Health and Asthma Management Program (CHAMP), a 16-session behavioral family lifestyle intervention (BFI) for school-age children with asthma and obesity and evaluated CHAMP in a randomized controlled trial compared with attention control. There were medium effect sizes favoring CHAMP for changes in body mass index z-scores, asthma control, and lung function among completers (ie, those who attended ≥9 of 16 sessions). Despite high rates of satisfaction reported by families, attendance and trial attrition were suboptimal, which raised concerns regarding the feasibility of CHAMP. Qualitative feedback from participants indicated 3 areas for refinement: (1) a less burdensome intervention modality, (2) a more individually tailored intervention experience, and (3) that interventionists can better answer health-related questions.

OBJECTIVE

We propose to improve upon our pilot intervention by developing the Mobile Childhood Health and Asthma Management Program (mCHAMP), a nurse-delivered BFI, delivered to individual families, and supported by a mobile health (mHealth) app. This study aims to (1) identify structural components of mCHAMP and (2) develop and test the usability of our mCHAMP app.

METHODS

Participants will be recruited from an outpatient pediatric pulmonary clinic. We will identify the structural components of mCHAMP by conducting a needs assessment with parents of children with asthma and obesity. Subsequently, we will develop and test our mCHAMP app using an iterative process that includes usability testing with target users and pediatric nurses.

RESULTS

This study was funded in 2018; 13 parents of children with asthma and obesity participated in the needs assessment. Preliminary themes from focus groups and individual meetings included barriers to engaging in health-promoting behaviors, perceived relationships between asthma and obesity, facilitators to behavior change, and intervention preferences. Participatory design sessions and usability testing are expected to conclude in late 2019.

CONCLUSIONS

Outcomes from this study are expected to include an mHealth app designed with direct participation from the target audience and usability data from stakeholders as well as potential end users.

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/13549
Self-Management Maintenance Inhalation Therapy With eHealth (SELFIE): Observational Study on the Use of an Electronic Monitoring Device in Respiratory Patient Care and Research (Preprint)
Authors: Kuipers Esther , Poot Charlotte C , Wensing Michel , Chavannes Niels H , de Smet Peter AGM , Teichert Martina
Published: February 2019

BACKGROUND

Electronic inhalation monitoring devices (EIMDs) are available to remind patients with respiratory diseases to take their medication and register inhalations for feedback to patients and health care providers as well as for data collection in research settings.

OBJECTIVE

This study aimed to assess the validity as well as the patient-reported usability and acceptability of an EIMD.

METHODS

This observational study planned to include 21 community pharmacies in the Netherlands. Patient-reported inhalations were collected and compared to EIMD registrations to evaluate the positive predictive value of these registrations as actual patient inhalations. Patients received questionnaires on their experiences and acceptance.

RESULTS

A convenience sample of 32 patients was included from across 18 pharmacies, and 932 medication doses were validated. Of these, 796 registrations matched with patient-reported use (true-positive, 85.4%), and 33 inhalation registrations did not match with patient-reported use (false-positive, 3.5%). The positive predictive value was 96.0%, and 103 patient-reported inhalations were not recorded in the database (false-negative, 11.1%). Overall, patients considered the EIMD to be acceptable and easy to use, but many hesitated to continue its use. Reminders and motivational messages were not appreciated by all users, and more user-tailored features in the app were desired.

CONCLUSIONS

Patients’ interaction with the device in real-world settings is critical for objective measurement of medication adherence. The positive predictive value of this EIMD was found to be acceptable. However, patients reported false-negative registrations and a desire to include more user-tailored features to increase the usability and acceptability of the EIMD.
Mobile Health Divide Between Clinicians and Patients in Cancer Care: Results From a Cross-Sectional International Survey (Preprint)
Authors: Tarricone Rosanna , Cucciniello Maria , Armeni Patrizio , Petracca Francesco , Desouza Kevin C , Hall Leslie Kelly , Keefe Dorothy
Published: February 2019

BACKGROUND

Mobile technologies are increasingly being used to manage chronic diseases, including cancer, with the promise of improving the efficiency and effectiveness of care. Among the myriad of mobile technologies in health care, we have seen an explosion of mobile apps. The rapid increase in digital health apps is not paralleled by a similar trend in usage statistics by clinicians and patients. Little is known about how much and in what ways mobile health (mHealth) apps are used by clinicians and patients for cancer care, what variables affect their use of mHealth, and what patients’ and clinicians’ expectations of mHealth apps are.

OBJECTIVE

This study aimed to describe the patient and clinician population that uses mHealth in cancer care and to provide recommendations to app developers and regulators to generally increase the use and efficacy of mHealth apps.

METHODS

Through a cross-sectional Web-based survey, we explored the current utilization rates of mHealth in cancer care and factors that explain the differences in utilization by patients and clinicians across the United States and 5 different countries in Europe. In addition, we conducted an international workshop with more than 100 stakeholders and a roundtable with key representatives of international organizations of clinicians and patients to solicit feedback on the survey results and develop insights into mHealth app development practices.

RESULTS

A total of 1033 patients and 1116 clinicians participated in the survey. The proportion of cancer patients using mHealth (294/1033, 28.46%) was far lower than that of clinicians (859/1116, 76.97%). Accounting for age and salary level, the marginal probabilities of use at means are still significantly different between the 2 groups and were 69.8% for clinicians and 38.7% for patients using the propensity score–based regression adjustment with weighting technique. Moreover, our analysis identified a gap between basic and advanced users, with a prevalent use for activities related to the automation of processes and the interaction with other individuals and a limited adoption for side-effect management and compliance monitoring in both groups.

CONCLUSIONS

mHealth apps can provide access to clinical and economic data that are low cost, easy to access, and personalized. The benefits can go as far as increasing patients’ chances of overall survival. However, despite its potential, evidence on the actual use of mobile technologies in cancer care is not promising. If the promise of mHealth is to be fulfilled, clinician and patient usage rates will need to converge. Ideally, cancer apps should be designed in ways that strengthen the patient-physician relationship, ease physicians’ workload, be tested for validity and effectiveness, and fit the criteria for reimbursement.
Comparative Study of CaSO4 and Papain Enzyme as Coagulants in The Tofu Production
Authors: Rizkaprilisa Windy , Setiadi Setiadi
Published: February 2019

Tofu is a high protein food which is widely consumed in Indonesia. In this study, we used the variety of coagulant which is CaSO4 and papain enzymes. The extraction of soybean protein was conducted using selected ratio (1:2), then coagulated using two different coagulant which are CaSO4 (1 and 2 gram) and papain enzyme (3 and 6 gram). The highest yield of tofu used CaSO4 2 gram with 66% yield and papain enzyme 6 gram with 65% yield. This indicates that more of coagulant are used so more yield of tofu. Based on the proximate test, especially proteins showed the making of tofu with papain enzyme (9.29%) gave higher protein content than CaSO4 (6.50%) as coagulant.Keywords: Tofu, soybean, CaSO4, papain enzyme
Prediction of Length of Study of Student Applicants Using Case Based Reasoning
Authors: Aesyi Ulfi Saidata , Wardoyo Retantyo
Published: February 2019

Graduation is important matter in college. Length of study can be used to evaluate curriculum. It affect accreditation score of the sutdy program. Based  on Akreditasi Program Studi Magister Buku V Pedoman Penilaian Instrumen Akreditasi 3rd standard there is rule about students and graduation, such as profile of the graduates including average length of study time and gpa (grade point average) of graduates.In this study, system built to predict Gadjah Mada University Master of Computer Science student applicant’s length of study. It used new case with 13 features from applicant that will be predict as new case, then calculate local similarity using euclidean distance and hamming distance while global similarity using nearest neighbor. Maximum value of global similarity taken as solution while revised will be done if it’s value below threshold.Result of this study show that system can help study program to manage educational process. It show 76% accuracy of 50 data.
A educação ambiental estética e as relações de pertencimento no processo de ambientalização curricular
Authors: Mota Junior Cesar , Cousin Cláudia Da Silva , Kitzmann Dione Iara Silveira
Published: February 2019

A Ambientalização Curricular se tornou um assunto importante para refletir sobre as situações envolvendo a esfera socioambiental vivenciadas cotidianamente. Esses problemas se agravam à medida que o sentimento de pertencimento aos lugares se enfraquece. Pautados nessas questões e refletindo sobre o papel da Educação Ambiental para a (re)apropriação desse sentido de pertença, este ensaio, emergente das reflexões estabelecidas na disciplina “A relação de pertencimento na constituição dos educadores ambientais” do Programa de Pós-Graduação em Educação Ambiental da Universidade Federal do Rio Grande – FURG, se propõe discutir acerca da Educação Ambiental Estética como uma possível ferramenta ao fortalecimento das relações de pertencimento na Ambientalização Curricular. Pressupõe-se que, sem este fortalecimento, não há uma efetiva participação dos sujeitos na implementação do processo de ambientalização, que passa a ser visto fragmentado e sem significados para a comunidade universitária.
Imprensa no Oeste de Santa Catarina: um discurso em prol da instrução pública para as crianças durante o Estado Novo
Authors: Lazarotto Aline Fatima , Arend Silvia Maria Fávero
Published: February 2019

A imprensa desempenhou um papel importante no processo de introdução da população infanto-juvenil na escola pública na região oeste do estado de Santa Catarina no século XX. Este artigo objetiva analisar as notícias veiculadas pelo primeiro jornal publicado nessa região do estado de Santa Catarina – A Voz de Chapecó –, no período entre 1939 e 1941, sobre a escolarização da infância. O jornal, num conjunto de reportagens, divulgou o discurso oficial do governo do estado de Santa Catarina sobre a necessidade de implementar a instrução pública na região e no período, bem como sobre as características que deveriam nortear a educação intelectual e moral das crianças.
O pensamento decolonial e o ensino de História
Authors: Pereira Nilton Mullet , Paim Elison Antonio
Published: February 2019

Apresentação do dossiê.
ANALYTICAL SOLUTION OF THE FREQUENCY OF THE LOAD OSCILLATION AT AN ARBITRARY GIRDER NODE IN THE SYSTEM MAPLE
Authors: Kirsanov Mikhail N. , Tinkov Dmitriy V.
Published: February 2019

Introduction. We study the oscillations of a massive load on a planar statically definable symmetric truss of a regular type with parallel belts. Truss weight is not included. Free vertical oscillations are considered. The stiffness of the truss rods is assumed to be the same, the deformations are elastic. Lattice of the truss is double with descending braces and racks. New in the formulation and solution of the problem is the analytical form of the solution, which makes it possible in practice to easily evaluate the frequency characteristics of the structure depending on an arbitrary number of truss panels and the location of the load.
Materials and methods. The operators and methods of the system of computer mathematics Maple are used. To determine the forces in the rods, the knotting method is used. The common terms of the sequence of coefficients of solutions for different numbers of panels are obtained from solving linear homogeneous recurrent equations of various order, obtained by special operators of the Maple system. Dependence on two arbitrary natural parameters is revealed in two stages. First, solutions for fixed load positions are found, then these solutions are summarized into one final formula for frequency.
Results. By a series of individual solutions to the problem of load oscillation using the double induction method, it was possible to find common members of all sequences. The solution is polynomial in both natural parameters. Graphs constructed for particular cases, showed the adequacy of the approach. The discontinuous non-monotonic nature of the intermittent change depending on the number of truss panels and some other features of the solution are noted.
Conclusions. It is shown that the induction method, previously applicable mainly to statics problems with one parameter (number of truss panels), is fully operational to the problems of the oscillations of system with two natural parameters. It should be noted that significant labor costs and a significant increase in the time symbolic transformations in such tasks
Reconversión productiva a palma de aceite en el Valle del Tulijá, Chiapas, México. Impacto diferenciado por género.
Authors: Linares Bravo Bárbara C. , Zapata Martelo Emma , Nazar Beutelspacher Austreberta , Suárez San Román Blanca
Published: February 2019

A partir de la premisa que señala que los procesos globales impactan diferencialmente en el ámbito local y que sus implicaciones y respuestas se relacionan con las particularidades de cada territorio, este trabajo pretende dar cuenta del impacto genéricamente diferenciado que ha tenido la política pública, enmarcada en procesos económicos globales, que impulsa la reconversión productiva a palma de aceite en las pequeñas unidades productivas pertenecientes a tres localidades indígenas del Valle del Tulijá, Chiapas, México. La información presentada se recolectó y analizó a través de un enfoque mixto de investigación, utilizando la encuesta y la entrevista semiestructurada como herramientas fundamentales. Inicialmente se analiza el contexto local, encontrando asimétricas relaciones de género a nivel familiar y comunitario. Posteriormente, se describe la expresión de la política pública de reconversión productiva a palma de aceite en las comunidades, especialmente a partir de la transformación de las actividades económicas, mostrando su incidencia sobre la provisión local de alimentos y la monetarización del ingreso familiar. Finalmente se identifica el impacto diferenciado por género encontrando que, con base en las desiguales relaciones de género, la reconversión productiva a palma de aceite conlleva mayores desventajas para las mujeres.
Eficiencia y agricultura familiar: más de un siglo de debate sin suficientes respuestasâ€¡
Authors: Rodríguez Sperat Ramiro , Jara Cristian Emanuel
Published: February 2019

La agricultura familiar atraviesa por un momento de creciente legitimidad en América Latina, al punto de que muchos gobiernos han dispuesto una serie de medidas tendientes a visibilizar y potenciar el sector. Sin embargo, la eficiencia productiva de este tipo de agricultura ha sido cuestionada en diversas oportunidades y por parte de distintas corrientes de pensamiento. Consecuentemente, y a la luz de las expectativas que existen sobre el sector desde múltiples vertientes políticas y académicas, resultaría conveniente revisar críticamente los argumentos que le asignan -según sea el caso- una mayor omenor eficiencia en su producción. A partir de recuperar yponer en diálogos los textos clásicos y contemporáneos que abordaron, directa o indirectamente la cuestión, este trabajo intenta demostrar que la discusión no es nueva, que los autores que han tratado el tema han hecho un uso polisémico de los conceptos involucrados, que la evidencia empírica utilizada para construir los distintos argumentos es difusa, y que todos estos elementos han actuado en forma conjunta para en la actualidad el debate siga abierto. Reconstruir y analizar dichos argumentos resulta un prerrequisito básico para poder argumentar a favor del potencial estratégico y la formulación de políticas públicas productivas (y no solo asistenciales) para el sector.
AAO 2018 Anterior Segment Section Symposium: Biologic Therapy: Applications in Anterior Segment Disease
Authors: Hogan Casey L. , Periman Laura M. , Scales David
Published: February 2019

Overview of the  AAO 2018 Anterior Segment Section Symposium.
Ficção científica e política econômica em "O Homem do Futuro"
Authors: Silva Andrade Maria Estela , De Carvalho Piassi Luís Paulo
Published: February 2019

Desde o início de seu processo de formação, o Brasil tem sido clamado como “o país do futuro”. Mesmo com alternâncias de regimes e projetos políticos, tal mito se renova e se sustenta. Como objeto cultural e midiático, o cinema, e a ficção científica como um de seus gêneros, propaga discursos que vão além de uma questão plástica, tendo efeitos políticos e sustentando ideologias (Kellner, 2001). A partir de uma metodologia que une a semiótica greimasiana à análise do discurso sob o ponto de vista dos Estudos Culturais, temos como objetivo analisar como o discurso desenvolvimentista está inserido no filme O homem do futuro (Claudio Torres, 2011), levando em conta o momento histórico e cenário político da época. Os resultados nos permitem fazer um paralelo da evolução narrativa com as mudanças no cenário econômico do Brasil entre 1991 e 2010.
AAOIFI governance standards: Sharia disclosure and financial performance for Islamic banks
Authors: Albarrak Hesham , El-Halaby Sherif
Published: February 2019

The uniqueness of Islamic banks (IBs) is shown through compliance with Islamic law (Sharia) which is approved through Sharia Supervisory Board (SSB) and presented for stakeholders by Sharia Supervisory Board Report (SSBR). This study seeks to achieve three main objectives as follows: (1) it identifies the degree of IBs’ transparency in compliance with Sharia and their commitment with the governance standards that issued by Accounting and Auditing Organization for Islamic Financial Institutions (AAOIFI); (2) it aims to measure the impact of adoption AAOIFI on the degree of Sharia disclosure; and (3) it seeks to test the economic consequences of Sharia disclosure based on its impact on financial performance. We analyse content of annual reports and websites of 120 IBs across 20 different countries for year 2016. Regression analysis shows compliance level for Sharia disclosure based on our index for SSBR is 53% with higher level compliance for IBs that apply AAOIFI standards comparing with banks that adopting International Financial Reporting Standards (IFRS). Therefore, adopting AAOIFI has a positive effect on enhancing the degree of Sharia disclosure. Moreover, Sharia compliance has a positive influence on financial performance based on both Returns on Assets (ROA) and Tobin’s Q as a robustness test. This study adds value to Islamic accounting literature by being a primary study. There is a lack of research on the topic and this paper measures the consequences of Sharia disclosure over the financial performance of IBs as well as the role of Islamic standards (AAOIFI) in enhancing the image of Islamic banks through supporting their compliance with Sharia.
Prevalence of spondyloarthritis and its subtypes - are they really comparable?
Authors: Zlatkovic-Svenda Mirjana , Stojanovic Roksanda , Sipetic-Grujicic Sandra , Radak-Perovic Marija , Guillemin Francis
Published: February 2019

Introduction/Objective. Increasing spondyloarthritis (SpA) prevalence in the last several decades cannot be attributed to disease manifestations alone. The objective of this paper is to review the prevalence of SpA and its subtypes: ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), SpA related to inflammatory bowel disease (IBD) and undifferentiated SpA (UnSpA). Methods. MEDLINE literature search was done via PubMed, Google Scholar, and Embase databases, using terms for spondyloarthritis, and prevalence, with an additional hand searching. Results. As compared with southern European countries, northern European countries (Scotland, Sweden, France) showed lower SpA prevalence rates (0.21?0.45% vs. 1.06% and 1.35% in Italy and Turkey, respectively). The lowest world SpA prevalence was in African and Southeast Asian countries (0?0.19%), and the highest was in Alaska (2.5%). The widest variability in PsA prevalence was in Europe (northern 0.02?0.19%, southern 0.42%). The lowest world PsA prevalence was in Japan (0.001%), followed by China (0.01?0.10%). The European ReA prevalence ranged from 0.04% in Greece to 0.10% in Serbia and Germany, and the European UnSpA prevalence varied from 0.02% in Serbia to 0.67% in Germany; the highest world UnSpA prevalence was in Lebanon (3.4%). Studies aimed at estimating the SpA prevalence differed in sampling strategy and confirmation criteria, different cutoffs for age groups inclusion, presentation of standardized or row results, etc. Conclusion. Variation in the SpA prevalence cannot be attributed to genetic or geographic distribution only. Differences in methodology of studies add to the diversification, described more in-depth in this review.
Peculiarities of using slurry fuels in thermal power plants
Authors: Shevyrev Sergey , Bogomolov Aleksandr , Vershinina Ksenia , Valiullin Timur , Kuznetsov Geniy , Lyrshchikov Sergey
Published: February 2019

The study regards the issues of increasing the thermodynamic efficiency of a typical condensing thermal power plant using coal-water and organic coal-water fuels as the main source. The attention is paid to the use of the phase transition heat of the water vapor of the flue gas. We have shown that it is possible to increase the power plant efficiency by about 3.7% (gross) relative to the base value (in the case of using pulverized coal). We propose to use the flue-gas desulfurization technology for creating fuel slurries in which a liquid incombustible base will be replaced, for example, with aqueous solutions of Ca(OH)2. This will create a closed water cycle, improve the efficiency of Sox flue gas purification and improve the performance of scrubbers.
Uniaxial compressive strength and failure characteristics of arkosic sandstone after thermal treatment
Authors: Zhang Yuan , Ma Yangsheng , Gu Bin , Ta Xupeng , Wang Qun
Published: February 2019

Experiments were conducted to study the mechanical characteristics of arkosic sandstones sampled from Pingyi, China. Rock samples were all thermally treated under the temperature ranging from room temperature to 800?C. Results show that as the treatment temperature rises, the arkosic mineral composition does not change obviously, but the mechanical behaviors change regularly. Variation trend changes dramatically at 200?C, 400?C, and 500?C. With thermal expan?sion of mineral particles being the dominant factor, mechanical behaviors barely change below 200?C. When temperature ranges from 200-400?C, it has an important effect on the mechanical properties because of the thermal fracture. From 400-500?C, mechanical properties change dramatically as a result of the mutual influence of thermal fracture, fusion and re-crystallization, but the thermal fracture is the leading factor. Because of the fusion and re-crystallization, fractures are partly filled, which results in partial recovering of the mechanical strength. With the combined action of thermal fracture, fusion and re-crystallization after 600?C, mechanical performance of arkosic sandstones degrades rapidly. Generally, the porosity and peak strain of arkosic sandstones increase with the temperature rising. However, the peak stress, elastic modulus and deformation modulus decrease simultaneously. Influenced by mineral particles? thermal expansion, thermal fracture, fusion, and re-crystallization and so on, the variation trend and amplitude are not the same at different temperature ranges, and the damage mechanism of sandstones also makes a difference.
Numerical-experimental validation of the welding thermal cycle carried out with the MIG welding process on a 6063-T5 aluminium tubular profile
Authors: Meseguer Valdenebro , Martínez-Conesa Eusebio , Portolés Antonio
Published: February 2019

The purpose of this work is to validate the thermal welding cycle obtained experimentally with the metal inert gas (MIG) welding process on a 6063-T5 aluminium tubular profile using the finite element method. The assembly formed by the tubular profile and the weld bead obtained experimentally is represented in an accurate way, taking care of both the geometry and the contour of the weld bead. The precision achieved in the numerical-experimental validation carried out by means of the finite element method is due to the care that has been taken in drawing the welded piece together with the weld bead made experimentally. In the validation carried out, the experimental and numerical cooling curves and the critical cooling time between 400 and 300?C (t4/3 ) in both curves are compared.
Experimental investigation on the effect of soil type to the ground source heat pump’s performance and energy consumption
Authors: Acar Bahadır
Published: February 2019

In the present study an experimental investigation is carried out to predict the performance of ground source heat pump systems with using different soil type under Karabuk prevailing conditions. A series of experiments were conducted on designed and produced experimental test rig. This study examines the effect of five different soil types on the performance and energy consumption of a heat pump. The experimental analysis showed that the evaporator capacity provided by sand was 46% and 42% higher than the capacity provided by red soil at the air-flow rates of 0.087 kg/s and 0.015 kg/s, respectively. In terms of the condenser capacity, sand provided 46% and 30% higher capacity than red soil at the air-flow rates of 0.087 kg/s and 0.015 kg/s, respectively. On the other hand, red soil consumed 8% and 6% less energy than sand at the air-flow rates of 0.087 kg/s and 0.015 kg/s. The capacities provided by other soil types and their energy consumption ranged between these values. In terms of the COP values, red soil provided 6% higher performance than sand and humus soil at the air-flow rates of 0.087 kg/s and 0.015 kg/s. The performance values obtained with other soil types ranged between these values.
Corrigendum: Mixed convection of functionalized DWCNT-water nanofluid in baffled lid-driven cavities
Authors: Editorial E
Published: February 2019

Simeon Oka, Editor-in-Chief of the journal Thermal Science request that it
is necessary write exact FAMILY NAME of the 4th author MIXED CONVECTION OF
FUNCTIONALIZED DWCNT-WATER NANOFLUID IN BAFFLED LID-DRIVEN CAVITIES MIXED
CONVECTION OF FUNCTIONALIZED DWCNT-WATER NANOFLUID IN BAFFLED LID-DRIVEN
CAVITIES by Mohammad HEMMAT ESFEa, Ali Akbar ABBASIAN ARANIb, Wei-Mon
YANc, Alireza AGHAIEb, Masoud AFRANDa, and Nima SINAa published in the
journal Thermal Science, Year 2018, No. 6A, Vol. 22, pp. 2503-2514 since
due to typing error of the Editorial staff, name of the 4th author Alireza
AGHAEI was not correctly written, as: Alireza AGHAIE must be written as:
Alireza AGHAEI.

 Link to the corrected article 10.2298/TSCI160225216E
Much Ado about Nothing: The (Lack of) Economic Impact of Data Privacy Breaches
Authors: Richardson Vernon J. , Smith Rodney E. , Watson Marcia Weidenmier
Published: February 2019

In this paper, we examine the consequences of data breaches for a breached company. We find the economic consequences are, on average, very small for breached companies. On average, breaches result in less than −0.3 percent cumulative abnormal returns in the short window around the breach disclosure. Except for a few catastrophic breaches, the nominal difference in cumulative abnormal returns between breach companies and the matched companies disappears within days after the breach. We also test whether data breaches affect future accounting measures of performance, audit and other fees, and future Sarbanes-Oxley Section 404 reports of material internal control weaknesses, but find no differences between breach and matched companies. Our results address the question why companies are not spending more to reduce breaches. We conclude by providing a few explanations of why there appears to be an effect at the economy-wide level, but no noticeable effect on individual company performance.
Analisis Kesulitan Belajar dan Miskonsepsi Mahasiswa dalam Praktikum Berbasis Proyek
Authors: Nasir Muhammad
Published: February 2019

Abstract: The aim of this study is to analyze the difficulty of learning and student collage misconception on experiment base project. Research approach used is qualitative descriptive. Student college misconception is tested by Certainty of Response Index (CRI). The subject of this research is physics education student collage of Palangka Raya Islamic state institute. Result of this research show that difficulty of learning student collage are 9% on determining the topic, 9% on identification of device and matter, 22% on arranging the procedure, 35% on arranging the schedule of project, 39% on collecting the data, 4% on displaying the data, 87% on choosing the data analysis technique, 13% on discussing the result of data analysis, and 4% on concluding the result of data analysis. Misconception of student collage on data analysis technique is 74,64% and not understanding the concept is 3,92%. Result of this research is concluded that the highest of learning difficulty of student collage on choosing the data analysis technique. This case is caused by misconception and not understanding of student collage on data analysis technique. Suggestion of this research is comprehension of student collage on concept of data analysis technique be needed before implementing experiment base project.
GOOD CORPORATE GOVERNANCE, ANALYST COVERAGE, DAN TAHAPAN DAUR HIDUP TERHADAP KEBIJAKAN DIVIDEN
Authors: Murhadi Werner R. , Wijaya Liliana Inggrit
Published: February 2019

This research objective is to observe the influences of good corporate governance, analyst coverage, company life cycle, investment opportunities set, size, and profitability towards the dividend policy. This study employs the corporate data from Indonesian Stock Exchange during 2005-2008 and weighted least square methods. The latest sample is 279 years of observation. The result shows that only life cycle stage of the company and its profitability are influential towards the dividend policy. The findings show that the relationship between the good corporate governance is consistent with the hypothesis but not significant.
GROWTH AND MATURITY HYPOTHESES ON DIVIDEND POLICY: INDONESIAN PERSPECTIVE
Authors: Ismiyanti Fitri
Published: February 2019

This research is aimed at testing the increase and decrease in dividends in relation to market reaction intertwined with the profitability of the firm. The main contribution of this study is the separation of the market reaction based on the firm’s lifecycle. The differentiation of the firm’s lifecycle purports to analysis whether there is distinguished influence between the increase (decrease) in dividends on firms at growth stage and that on firms at maturity stage. Data used are manufacturing firms listed on the Indonesia Stock Exchange for the period of 1994-2008.
THE EFFECT OF CONSUMER FACTORS AND STORE IMAGE WHICH IS MODERATED BY PLB IMAGE TOWARDS PLB PURCHASE INTENTION
Authors: Gautama Maria Patricia , Haryanto Jony Oktavian
Published: February 2019

Nowadays the development of Private Label Brands (PLBs) is increasing; this is proven by the increasing number of PLBs products in various product categories that we can found in several types of stores such as a supermarket, hypermarket format or in convenience store. PLBs have a very good opportunity in the market, considering many consumers are realizing that the price of PLBs which tend to be cheaper and with good qualities when compared with the price of national brands or product manufacturer. It also becomes interesting when it is known that the opportunities are widely open and it is proven with more and more retailers which aggressively producing PLBs. They give consumers more choices with a more affordable price but still provide good quality, especially in this world economy condition that tends to go down which of course also affect consumer purchasing power. By these reasons, the aim of the study is to determine whether the consumer and store image factors have a significant relationship in encouraging consumers to make PLB purchases, especially when it is moderated by PLB Image. The results showed that there are significant effect from consumer factors and stores image toward PLB purchase intention and its getting increase with the moderation of the PLB image.
BUDAYA LINGKUNGAN DAN NORMA SEBAGAI FAKTOR PENENTU PERILAKU KONSUMEN TERHADAP PRODUK BERWAWASAN LINGKUNGAN
Authors: Heruwasto Ignatius
Published: February 2019

The characteristic of green product is different compare to conventional product, and makes a gap on the theory to explain attitude and behavior toward green product. The objective of this article to find the determinant factors of consumer behavior toward green product. This article uses the theories from consumer behavior and marketing literature to construct an integrative and comprehensive nomological model, to explain the determinant factors influence the attitude and behavior on green product. This article includes a new value concept, the green values, and with the norms become an important factor that influence perceived customer value, attitude and behavior on green product. The article points out that the green culture is the key determinant factor to increase the use of green product, and the green culture should be cultivated to prevent the environment degradation from the consumption of conventional product.