bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive Significance of Glycolysis-Associated lncRNA Profiles in Colorectal Cancer Progression
Authors: Xu Chenxin , Peng Yurui , Zhang Quanzheng , Wang Zheng , Liu Yanjun , Mao Rui , Li Ming
Published: September 2023

Background
The Warburg effect constitutes a signature characteristic of colorectal cancer (CRC). Although there have been extensive investigations in the past, the implications of long non-coding RNAs (lncRNAs) in modulating the Warburg effect are still not fully elucidated. Our research primarily focuses on uncovering lncRNAs that potentially regulate the Warburg effect by acting as competing endogenous RNAs (ceRNAs).
Methods
We sourced glycolysis-associated genes from the Kyoto Encyclopedia of Genes and Genomes (KEGG) and identified 101 glycolysis-linked lncRNAs in CRC via bioinformatics techniques. Through a combination of Univariable Cox regression, Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis, and multivariable Cox regression evaluations, we designed a prognostic model consisting of four distinct glycolysis-related lncRNAs. Subsequently, a prognostic nomogram was conceived integrating the glycolysis-associated lncRNA model and other pertinent clinical parameters.
Results
The robust prognostic efficacy of the quartet glycolysis-related-lncRNA signature and the corresponding nomogram was corroborated across both training and validation cohorts. Functional assays revealed a notable suppression in glycolysis and hexokinase II (HK2) expression upon silencing lncRNA RUNDC3A − AS1, a pivotal lncRNA within our prognostic signature. This underscores the significant regulatory role of lncRNA RUNDC3A − AS1 in the Warburg effect.
Conclusions
We have successfully highlighted glycolysis-centric lncRNAs in CRC. Through our prognostic model and nomogram, we accentuated the lncRNA RUNDC3A − AS1's crucial prognostic and regulatory role in the Warburg effect within colorectal cancer cells.
Effect of Ursolic Acid, Selenium Nanoparticles, and Their Combination on the Metastasis-Associated Gene Expression in MDA-MB-231 Breast Cancer Cells: In-vitro Study
Authors: Azimi Farnaz , Sanaei Marzieh , Rahimzadeh Sara , Ajideh Ramak , Shahverdi Ahmad Reza , Yazdi Mohammad Hossein
Published: September 2023

Metastasis is a leading cause of cancer-related mortality. Triple-negative human breast carcinoma (TNBC) exhibits increased invasion and metastatic activity compared to other types of breast cancer, often resulting in a poor prognosis. The aim of this study was to examine the impact of selenium nanoparticles (SeNPs), ursolic acid, and their combination on the MDA-MB-231 TNBC cell line in terms of their potential antiproliferative and antimetastatic effects. The cytotoxic effect of the aforementioned substances was evaluated using an MTT assay. Additionally, their impact on the expression levels of ICAM-1, a transmembrane glycoprotein that promotes metastasis, and two matrix metalloproteinases (MMP-2 and MMP-9) that are essential for tumor invasion and migration, was investigated by using real-time PCR. Moreover, the scratch assay was used to observe cell migration after SeNPs and ursolic acid treatment. The findings suggest that although applying 150 µg/mL SeNPs and 20 µg/mL UA separately revealed more cell inhibition rate, a combination group of SeNPs and ursolic acid not only decreases the viability of cancer cells in comparison to the control group, but also harbors synergistic actions in reducing the migration and metastasis of MDA-MB-231 cells by their most effective downregulation of MMP-9, MMP-2, and ICAM-1 expression. It can be considered a novel potential treatment for triple-negative metastatic breast cancer (TNBC). However for better justification of this mechanism, more detailed studies on animal models should be performed.
Contribution of uniparental disomy to fetal growth restriction: a whole-exome sequencing series in a prenatal setting
Authors: Li Mengmeng , Hao Na , Jiang Yulin , Xue Huili , Dai Yifang , Wang Mingming , Bai Junjie , lv Yan , Qi Qingwei , Zhou Xiya
Published: September 2023

Fetal growth restriction (FGR), a leading cause of perinatal morbidity and mortality, is caused by fetal, maternal, and placental factors. Uniparental disomy (UPD) is a rare condition that leads to imprinting effects, low-level mosaic aneuploidies and homozygosity for pathogenic variants. In the present study, UPD events were detected in 5 women with FGR by trio exome sequencing (trio-WES) of a cohort of 150 FGR cases. Furthermore, noninvasive prenatal testing results of the 5 patients revealed a high risk of rare autosomal trisomy. Trio-WES showed no copy-number variations (CNVs) or nondisease-causing mutations associated with FGR. Among the 5 women with FGR, two showed gene imprinting, and two exhibited confined placental mosaicism (CPM) by copy number variant sequencing (CNV-seq). The present study showed that in FGR patients with UPD, the detection of imprinted genes and CPM could enhance the genetic diagnosis of FGR.
Ten Machine Learning Algorithms for Short-Term Forecasting: A Comparative Study in Gas Warning Systems
Authors: Wu Robert M.X. , Shafiabady Niusha , Zhang Huan , Lu Haiyan (Helen) , Gide Ergun , Liu Jinrong , Charbonnier Clement Franck Benoit
Published: September 2023

This research aims to explore more efficient machine learning (ML) algorithms with better prediction assessments for short-term forecasting. Up-to-date literature shows a lack of research on selecting practical ML algorithms for short-term forecasting in real-time industrial applications. The literature reviews the top-tier publications on ML algorithms used in China’s industrial applications and finds 29 algorithms. Among them, ten widely used ML algorithms are tested, including ARIMA, BP_Resilient, BP_SOG, KNN, LP, LSTM, Perceptron, RF, RNN, and SVM. A case study is conducted to compare the prediction error and predictive performance assessments. The top two ranked algorithms for prediction error assessment are ARIMA and LR. RF, SVM, BP_SOG, KNN, RNN, and BP_Resilient follow. Perceptron is the last ranked algorithm. For predictive performance assessment, ten algorithms are divided into five clusters: the best (KNN) with the shortest computational time (0.41683s), better (RF, LR, and SVM) with between 1s and 2s, good (Perceptron, BP_SOG, and BP_Resilient) with between 2s and 3s, worse (ARIMA and RNN) with more than 3s, and the worst (LSTM) with the longest computational time (145.19s). Based on the outcomes of comparative analysis, ten ML algorithms can be finally classified into four categories: optimal, efficient, suboptimal, and inefficient. LR and RF are optimal algorithms. Efficient algorithms include SVM, KNN, and ARIMA. Suboptimal algorithms include BP_SOG, BP_Resilient, RNN, and Perceptron. LSTM is an inefficient algorithm. This research finds different results from previous studies between LSTM, KNN, and SVM. The research outcomes significantly explore different views on the performance of ARIMA, LR, KNN, RF, RNN, and SVM compared to previous studies. They are valuable for further research. Finally, this research contributes 20 research questions for further investigation.
Adherence type impacts completion rates of frequent mobile cognitive assessments among older adults with and without cognitive impairment
Authors: Christianson Kieffer , Prabhu Meha , Popp Zachary T , Rahman Md Salman , Drane James , Lee Marissa , Lathan Corinna , Lin Honghuang , Au Rhoda , Sunderaraman Preeti , Hwang Phillip H
Published: September 2023

Background
Prior to a diagnosis of Alzheimer’s disease, many individuals experience cognitive and behavioral fluctuations that are not detected during a single session of traditional neuropsychological assessment. Mobile applications now enable high-frequency cognitive data to be collected remotely, introducing new opportunities and challenges. Emerging evidence suggests cognitively impaired older adults are capable of completing mobile assessments frequently, but no study has observed whether completion rates vary by assessment frequency or adherence type.
Methods
Thirty-three older adults were recruited from the Boston University Alzheimer’s Disease Research Center (mean age = 73.5 years; 27.3% cognitively impaired; 57.6% female; 81.8% White, 18.2% Black). Participants remotely downloaded and completed the DANA Brain Vital application on their own mobile devices throughout the study. The study schedule included seventeen assessments to be completed over the course of a year. Specific periods during which assessments were expected to be completed were defined as subsegments, while segments consisted of multiple subsegments. The first segment included three subsegments to be completed within one week, the second segment included weekly subsegments and spanned three weeks, and the third and fourth segments included monthly subsegments spanning five and six months, respectively. Three distinct adherence types – subsegment adherence, segment adherence, and cumulative adherence – were examined to determine how completion rates varied depending on assessment frequency and adherence type.
Results
Adherence type significantly impacted whether the completion rates declined. When utilizing subsegment adherence, the completion rate significantly declined (p = 0.05) during the fourth segment. However, when considering completion rates from the perspective of segment adherence, a decline in completion rate was not observed. Overall adherence rates increased as adherence parameters were broadened from subsegment adherence (60.6%) to segment adherence (78.8%), to cumulative adherence (90.9%).
Conclusions
Older adults, including those with cognitive impairment, are able to complete remote cognitive assessments at a high-frequency, but may not necessarily adhere to prescribed schedules.
Investigation of Polymeric Nanoparticles Encapsulating Natural Sources for Targeting of Cancer
Authors: Khan Javed , Yadav Shikha
Published: September 2023

Herbal medications have emerged as a prominent focus within the pharmaceutical industry due to their well-established efficacy and limited occurrence of adverse effects. Additionally, natural medicines display a comparable amount of interest in the creation of nanoparticle as compared to synthetic drugs. Polymeric nanoparticles have become an important tool for increasing drug bioavailability and enabling tailored delivery to the intended site of action. because of the analgesic, anti-inflammatory, antibacterial, and antioxidant benefits of its therapeutic qualities. Formulations were prepared using different ingredients using the solvent evaporation method. Polyvinyl alcohol, Polylactic acid was used as a biodegradable polymer, HPMC, Polyvinylpyrrolidone (PVP), and Lactose. 5- Fluorouracil is acts as an inhibitor of receptor thymidylate synthase (TS) and chemotherapeutic drug. Vaccinium Corymbosum was extracted by the Soxhlet method. The extract of the Vaccinium Corymbosum was encapsulated, Quercetin is the flavonoid that worked as a main constituent. The current study indicates that Vaccinium Corymbosum-loaded nanoparticles assist in the anti-cancer activity effectively.
Estimation of Moss Harvest Amount and Biomass per Hectare for Sustainable Moss Harvesting in Türkiye
Authors: URSAVAŞ Serhat , SÖYLER Recep
Published: September 2023

While moss harvesting is legally permitted in Turkey, the lack of inventory studies in harvested areas puts significant pressure on moss species. Additionally, there are not enough studies on how much moss can be harvested per hectare from well-maintained forest areas. Eldivan Mountain with a size of 4,200 ha was chosen as the study area. In this area, a sampling point was determined every 300 meters. At each point, moss species were detected in an area of 4 m2 on the ground and 50 m2 on the tree. The total identified moss taxa cover an estimated area of approximately 97,216,557 m2, and their air-dry weight is 44,640,972 kilograms. The most widely distributed species on the ground is Syntrichia ruralis with 64,772,801 m2 and 623,268 kg. On the tree, it is Hypnum cupressiforme var. lacunosum with a width of 3,937,266 m2 and 1,448,533 kg. Harvesting of these species is not correct since there is not enough rainfall in Turkey to develop epiphytic moss taxa. For sustainable moss harvest, it is best to harvest 1/3 of its total wealth. For a sustainable moss harvest, it is recommended to harvest 2 tons per hectare in Turkey. In addition, it should be kept in mind that moss harvesting without an inventory study may cause damage to rare, sensitive and endemic moss species.
The Relationship Between Severe Hypertensive Diseases of Pregnancy and Moderate-Severe Bronchopulmonary Dysplasia
Authors: Wymore Erica , Lynch Anne , Singh Jasleen , Thevarajah Tamara , Hodges Jennifer , Kinsella John , Auer Emily , Wagner Brandie
Published: September 2023

Objective: Determine the association between severe hypertensive disease of pregnancy (HDP) with moderate-severe bronchopulmonary dysplasia (BPD) in preterm infants (< 31 weeks’ gestation).
Study Design: Preterm birth cohort study of 693 mother-infant dyads. Severe HDPwas defined as severe preeclampsia, HELLP syndrome or eclampsia. The outcome was moderate-severe BPD classified at 36 weeks corrected gestational age, based on the NICHD Consensusstatement.
Results: 225 (32%) mothers developed severe HDP and 234 (34%) infants hadmoderate-severe BPD. There was an interaction between severe HDP and gestational age (p=0.03). Infants born at earlier gestational ages to mothers with HDP had increased odds for moderate-severe BPD compared to infants of normotensive mothers delivering at the same gestational age. Infants born at later gestational ages to mothers with severe HDP had decreased odds for the outcome.
Conclusions: Severe HDP has a differential effect on the development of moderate-severe BPD based on gestational age.
Existence and uniqueness of solutions for multi-order fractional differential equations with integral boundary conditions
Authors: Sun Jian-Ping , Fang Li , Zhao Ya-Hong , Ding Qian
Published: September 2023

In this paper, we consider the existence and uniqueness of solutions for a nonlinear multi-order fractional differential equation with integral boundary conditions.
By using a fixed point theorem and Banach contractive mapping principle, we obtain some existence and uniqueness results.
Kinetic description of scalar conservation laws with Markovian data
Authors: Rezakhanlou Fraydoun
Published: September 2023

We derive a kinetic equation to describe the statistical structure of solutions ρ to scalar conservation laws ρ_t = H(x, t, ρ)_x , with certain Markov initial conditions. When the Hamiltonian function is convex and increasing in ρ, we show that the solution ρ(x, t) is a Markov process in x (respectively t) with t (respectively x) fixed. Two classes of Markov conditions are considered in this article. In the first class, the initial data is characterize by a drift b which satisfies a linear PDE, and a jump density f which satisfies a kinetic equation as time varies. In the second class, the initial data is a concatenation of fundamental solutions that are characterized by a parameter y, which is a Markov jump process with a jump density g satisfying a kinetic equation. When H is not increasing in ρ, the restriction of ρ to a line in (x, t) plane is a Markov process of the same type, provided that the slope of the line satisfies an inequality.
Cell-cycle-related protein centromere protein F deficiencyinhibits cervical cancer cell growth by inducing ferroptosisvia Nrf2 Inactivation
Authors: Tang Xinhui , Zhao Tiannan , Guo Li , Liu Xinyue , Zhang Weina , Zhang Ping
Published: September 2023

Background Cervical cancer (CC)is one of the deadliest cancer types that seriouslythreatens women’s health. The Centromere protein F (CENPF) is the key protein inmitosis, which modulates a variety of cellular processes, including chromosomeseparation during mitosis. Bioinformatics study has shown that CENPF is a masterregulator that is overexpressed and activated in cervical cancer. However, the exactbiological function of CENPF in CC remains unclear.
Methods In this study, we investigated the expression level of CENPF in cervicalcancer tissues and cells by immunohistochemistry and western blot assay. Then weperformed a knockdown of CENPF by lentivirus transfection to explore the potentialbiological function of CENPF in CC cell lines. The role of CENPF in regulatingferroptosis was assessed by analyzing lipid reactive oxygen species (ROS), andmalonyl dialdehyde (MDA), transmission electron microscopy experiments, etc. Theresults obtained in vitro were further verified by a subcutaneous tumorigenic nudemouse model.
Results Our findings suggest that CENPF is highly expressed in CC patients and CCcell lines. In vitro and vivo experiments have shown that the knockdown of CENPFcan inhibit cell proliferation, cell migration, and cell invasion, and trigger ferroptosis.The ferroptosis induced by inhibiting CENPF in cervical cancer cell lines may bemediated by the Nrf2/HO-1 pathway.
Conclusion CENPF is significantly overexpressed in cervical cancer patients andaffects the biological effects of cervical cancer cells. Knockdown of CENPF inducesferroptosis in cervical cancer cell lines by activating Nrf2/HO-1 signaling. Thus,CENPF might serve as a novel prognostic biomarker and latent therapeutic target forcervical cancer patients.
Enhancing Watershed Governance through Collaborative Platforms: Evidence from Ecological Compensation Governance in China
Authors: Sun Yan , Li Wanru
Published: September 2023

Extensive research has been conducted on control and coordination in collaborative governance, and recent studies on “collaborative platforms” have shed light on the integration of these aspects. Collaborative platforms represent a governance strategy that surpasses traditional collaborative governance, allowing for the coexistence of control and coordination to foster broader and evolving cooperation. This paper focuses on the Xin’an River Ecological Compensation Collaborative Platform in China, using grounded theory coding techniques and procedures to explore its specific evolutionary process and mechanisms from a process perspective. This paper delves into the interaction, development, and functioning of control and coordination within this collaborative platform. The research uncovers an evolutionary trend in the Xin’an River Ecological Compensation Collaborative Platform characterized by scale expansion, governance maturity, structural complexity, and functional upgrading. The platform’s evolutionary mechanism shows the following progression: “Platform Driving Force - Platform Governance Tools - Platform Structure - Platform Functions”. Throughout its evolution, control and coordination exhibit dual strengths, but their emphasis varies at different phases of platform development. The paper makes a significant contribution by advancing the theory of collaborative platforms through empirical evidence from China. On the one hand, it provides empirical support for the theory in terms of platform operation logic, structure, functionality, and experimentation. On the other hand, it offers a more detailed explanation of how control and coordination operate within collaborative platforms by adopting a process perspective and drawing on research scenarios from China.
Investigating the Nexus between Solid Waste Management and Flooding in Ibadan, and Devising a Pragmatic Solution through a Mobile App
Authors: Ojedele Jubril , Ajagbe Abdulwasiu
Published: September 2023

Flooding is a recurring issue in Ibadan, and the improper management of solid waste has been identified as a potential contributing factor. Through a comprehensive analysis of existing literature, field surveys, and data collection, this study investigates the impact of solid waste on flooding in Ibadan and identifies the challenges faced in managing solid waste effectively as well as integrating innovative technology (by building a mobile application) into waste management systems to mitigate flooding risks. Data used for this study were both secondary and primary, in which the primary sources include the use of structured online questionnaire, interviews as well as personal observation, while secondary sources include desk study of reports from governmental and non-governmental institutions, existing research projects and so on. In addition, the use of sophisticated design tools like Figma and Flutter were used in the design of the Zero Flood mobile application. According to the research, only about 14.21% of the respondents claim they sort their wastes, 34.52% burn their wastes regularly. Also, 14.21% of respondents claim they empty their wastes into drains regularly, 6.60% do it occasionally while 36.04% claim they dump their wastes in unauthorized dumpsites. Similarly, 12.69% of the respondents said their drains are regularly blocked while 6.09% have it blocked occasionally. Analysis of the data and reports revealed that many of the residents still lack proper education on dealing with solid waste, and also, wastes collected by existing institutions are far lesser than that generated by households and institutions. This means that there is a need for proper popular participation in managing solid waste in the city so as to corroborate government’s efforts. Also, there needs to be proper alert and notification of an impending flood so as to mange the risks of flooding appropriately and efficiently.
THE CURRENT SITUATION OF INVESTIGATIVE INTERVIEWING OF CHILDREN IN THE UK AND TURKEY
Authors: BATMAN Hüseyin , GÖKÇEARSLAN Elif
Published: September 2023

Child maltreatment is a social problem that is emphasized and researched around the World. The phenomenon of sexual abuse is different from other types of abuse, since there is no eyewitness other than the victim and perpetrator. Children exposed to sexual abuse are sometimes pressured by family members to keep secret or deny what happened because the abuser is a family member which makes it difficult to reveal sexual abuse. Forensic interview is one of the most important tools in order to obtain information about what happened from the child who is the victim of abuse. The fact that the forensic interviewer is an expert in the field increases the probability of getting a full and correct answer from the child victim of abuse. The history of forensic interview with a child in the UK is older than in Turkey, the process that started in the late 1970s accelerated in the 1990s. The process of forensic interviewing with children in Turkey gained momentum especially with the publication of the Child Monitoring Center circular in 2012. It is pleasing that the number of Child Monitoring Centers affiliated to the Ministry of Health and Forensic Interview Rooms affiliated to the Ministry of Justice has increased rapidly since 2012. There is no forensic interview protocol yet in Turkey. It is believed that it would be appropriate to prepare a forensic interview protocol as soon as possible with the studies carried out on this subject. This article initially focus on investigative interviewing of children and then discuss the important components that may impact the children’s testimony. Interview aids, cognitive interview, multiple interviews with children and the role of interviewer will be outlined. In addition to that, investigative interviewing of children in the UK and Turkey will be discussed.
La multitude qui vient
Authors: Soares de Moura Costa Matos Andityas
Published: September 2023

Le présent article part d’une proposition de Giorgio Agamben issue du livre La communauté qui vient, consistant à penser une communauté non appropriable, c’est-à-dire, une communauté pour des individus ontologiquement indéterminés et qui ne pouvant pas être appropriés par les appareils du pouvoir. En ce sens, nous essayons de montrer comment la formation sociale conçue par Agamben peut dialoguer avec l’idée de multitude de Michael Hardt et Antonio Negri. À cette fin, sont exposées les similitudes entre la communauté « qui vient » de Agamben et la multitude. En séquence, nous discutons le rôle individualisant de la loi et de la politique occidentale, comprises comme mécanismes hiérarchiques dont la fonction est précisément d’empêcher l’émergence de la multitude.
Conversational Agents in Health Care: Expert Interviews to Inform the Definition, Classification, and Conceptual Framework
Authors: Martinengo Laura , Lin Xiaowen , Jabir Ahmad Ishqi , Kowatsch Tobias , Atun Rifat , Car Josip , Tudor Car Lorainne
Published: September 2023

Background

Conversational agents (CAs), or chatbots, are computer programs that simulate conversations with humans. The use of CAs in health care settings is recent and rapidly increasing, which often translates to poor reporting of the CA development and evaluation processes and unreliable research findings. We developed and published a conceptual framework, designing, developing, evaluating, and implementing a smartphone-delivered, rule-based conversational agent (DISCOVER), consisting of 3 iterative stages of CA design, development, and evaluation and implementation, complemented by 2 cross-cutting themes (user-centered design and data privacy and security).

Objective

This study aims to perform in-depth, semistructured interviews with multidisciplinary experts in health care CAs to share their views on the definition and classification of health care CAs and evaluate and validate the DISCOVER conceptual framework.

Methods

We conducted one-on-one semistructured interviews via Zoom (Zoom Video Communications) with 12 multidisciplinary CA experts using an interview guide based on our framework. The interviews were audio recorded, transcribed by the research team, and analyzed using thematic analysis.

Results

Following participants’ input, we defined CAs as digital interfaces that use natural language to engage in a synchronous dialogue using ≥1 communication modality, such as text, voice, images, or video. CAs were classified by 13 categories: response generation method, input and output modalities, CA purpose, deployment platform, CA development modality, appearance, length of interaction, type of CA-user interaction, dialogue initiation, communication style, CA personality, human support, and type of health care intervention. Experts considered that the conceptual framework could be adapted for artificial intelligence–based CAs. However, despite recent advances in artificial intelligence, including large language models, the technology is not able to ensure safety and reliability in health care settings. Finally, aligned with participants’ feedback, we present an updated iteration of the conceptual framework for health care conversational agents (CHAT) with key considerations for CA design, development, and evaluation and implementation, complemented by 3 cross-cutting themes: ethics, user involvement, and data privacy and security.

Conclusions

We present an expanded, validated CHAT and aim at guiding researchers from a variety of backgrounds and with different levels of expertise in the design, development, and evaluation and implementation of rule-based CAs in health care settings.
Brain Tumor Detection and Classification using Deep Learning
Authors: Banoo Fatima , Arora Heena
Published: September 2023

Abstract: This paper explores the application of convolutional neural networks (CNNs) in diagnosing brain tumors, focusing on children and the elderly who are most vulnerable to this type of cancer. Brain tumors pose significant health risks due to uncontrolled cell growth within the skull, making accurate classification challenging. The study utilizes CNNs, a popular machine learning approach, to classify 3260 brain magnetic resonance images into glioma, meningioma, pituitary, and no tumor categories. Three algorithms, CNN, VGG, and Densenet, are employed for classification. Early detection is vital for effective treatment, and computer-aided diagnostics show promise in assisting clinicians. This work provides an overview of traditional computer-aided tumor diagnosis and highlights the advantages of using CNNs. It discusses image segmentation, classification techniques based on CNN, Densenet, and VGG16, and serves as a guide for future tumor detection research. Data augmentation and min-max normalization enhance tumor cell contrast. The dense CNN model accurately classifies a small image database, and Densenet demonstrates remarkable performance. Experimental results show CNN achieving 45% accuracy on testing data, VGG achieving 51%, and Densenet achieving an impressive 86.49% during training, with high precision and a good F1 score. Overall, this paper emphasizes the potential of CNNs for brain tumor diagnosis and contributes to the development of computeraided diagnostic systems. It advances the field of medical image analysis and paves the way for further research in tumor detection.
Problems and Prospects of Organic Farming in India
Authors: Antil Dr. R. S. , Yadav Pramod
Published: September 2023

Abstract: Conventional farming not only helped India produce enough food for its own consumption but also generated surpluses for exports. However, the increasing population and income will lead to further increases in demand for food and for raw materials for industry. The modern system of farming, it is increasingly felt, is becoming unsustainable, as evidenced by declining crop productivities, damage to the environment, chemical contamination, etc. The necessity of having an alternative agriculture method that can function in a friendly eco-system while sustaining and increasing crop productivity is realized now. Organic farming is recognized as the best-known alternative to conventional agriculture. Organic farming is a system of cultivation of food grains that sustains the health of the soil and ecosystem. It is the system that avoids or largely excludes the use of artificial chemical inputs such as fertilizers, pesticides, hormones and feed additives in the field of agriculture. The major weaknesses of organic agriculture in the country are the absence of linkages between farmers and markets and the absence of financial support from governments. In this article, an attempt was made to highlight different issues resulting from recent developments, problems, and prospects in organic farming in India.
Modelo de desarrollo para el aprovechamiento de nopal verdura en Milpa Alta, Ciudad de México
Authors: López Flores María Magdalena , Omaña Silvestre José Miguel
Published: September 2023

Actualmente se producen tres veces más los alimentos necesarios para alimentar a toda la humanidad, sin em­bargo, un tercio de esta producción se desperdicia por la merma existente desde la producción hasta la etapa final de mercado. En México se desperdician anualmente 88 millones de toneladas de alimentos. Con respecto al nopal verdura (Opuntia ficus-indica (L.) Mill) se estima que 63.3% de la producción total se tira a la basura ya que hay un exceso de producción. El objetivo de la investigación fue diseñar un Modelo de Desarrollo Comunitario, para la industrialización y comercialización de nopal verdura a través de un proceso integrador y organizacional, con base en una cooperativa para la producción, deshidratación y comercialización de nopal orgánico, a fin de promover la participación local, considerando el bienestar de los productores y la susten­tabilidad de este proceso. La propuesta se basó en los tres pilares del desarrollo rural sostenible: economía, medio ambiente y sociedad y se evaluó con las cinco etapas que comprende el modelo de desarrollo integral. El resultado de esta evaluación sugiere que es viable llevar a cabo el modelo de desarrollo en la Alcaldía Milpa Alta, ya que existen las condiciones ambientales, sociales y económicas.
Vīnes bibliotekārs Roberts Mūzils un neizlasīto grāmatu fenomens
Authors:   LU Akadēmiskā bibliotēka, Garda Ilze
Published: September 2023

Robert Musil (06.11.1880–15.04.1942) was an Austrian writer, playwright and essayist who spent the last 20 years of his life writing his best-known novel which was destined to remain unfinished, “The Man Without Qualities” (“Mann ohne Eigenschaften”). Few people know that Robert Musil was an intern and librarian at the Technical University of Vienna from 1911 to 1914. It is this experience that is referred to in one of the chapters of the novel “The Man Without Qualities”, describing the secret of a good librarian being able to navigate a collection of more than three million books, because he never reads anything more than the title and the table of contents, since the person who becomes immersed into the contents is lost as a librarian.
Ziņas par Vidzemes mācītāja Frīdriha Bernharda Blaufūsa personīgo bibliotēku, grāmatu lasītāja un izplatītāja pieredzi
Authors:   Latvijas Nacionālā bibliotēka, Paškevica Beata
Published: September 2023

Friedrich Bernhard Blaufuß (1697–1756) is the author of the first history of the Latvian people, written in Latvian and intended for the Latvian reader, with the short title Livonian Histories. Recently, several more of his essays have been found, enabling us to learn more both about the personality of Blaufuß and his literary heritage. The rediscovered texts include a poem, whose title, translated into English, would read, as follows: “Livonian Monument to the glory of God’s work which resonated in the year of 1738 among Latvian and Estonian peasants in the Duchy of Livonia when they truly converted and changed their soulful hearts and lives and it became known to all across the entire world, due to deceitful untruth and false reports an un-partisan eyewitness reveals the truth in verse in the year of 1753”. The poem is dedicated to the awakening that occurred in Vidzeme under the influence of Herrnhut missionaries. He is also the translator of several hymns and possibly the author or translator of other essays stored in memory institutions. The Rarities Department of the University of Latvia Academic Library holds the only surviving copy of the printed auction catalogue for Blaufuß’ Library, which serves as one of the testimonies to the dissemination of early Enlightenment and Pietism literature in Europe, its presence in Vidzeme, as well as the horizon of Vidzeme literary figures’ religious interests and the body of knowledge available to educated Vidzeme readers in the first half of the 18th century. The catalogue lists 749 items, which implies a relatively large private library in Riga. The catalogue represents a very wide range of Pietism literature, from the works of Johann Arndt and Philipp Jacob Spener to representatives of radical Pietism, such as, for example, Gottfried Arnold. The catalogue also includes reference books and periodicals. Friedrich Bernhard Blaufuß was also a book distributor for the Unity of Brethren in Vidzeme. This fact was one of the main points of the accusation levelled against him in the 1742 and 1743 trials of the Herrnhutians.
Bibliotēka un lasīšana. Lasīšanas hermeneitiski fenomenoloģiska analīze
Authors: Gediņa Linda
Published: September 2023

Hermeneutically-phenomenologically understanding the question “what is reading?” – the Author’s work is to be read and the Author provides the possibility of following the path shown by the Author in order to get to the [ontological] field of play chosen and created by the Author, where, in turn, not the Author’s statements, descriptions of beings appear, but the reader is given the possibility of understanding this world that the Author has created for him – he is provided with a space, a field of play for understanding, where to play with the possibilities of meanings offered by language – thinking his own thoughts, he does not yield so easily to games and play. The Author offers a new language, and a great deal of freedom and participatory choice – reading even allows one to escape the mundane, or in Hugo Ball’s words, “escape out of time”. In this new spatiality of the world: the trees grow out of the letters, at the same time someone asks for someone’s hand, and Mr. Schulze rides on the tram yawning (See: Dada’s Manifestoes, sound poems); but it [the Author’s work] must always be in harmony with the idea [of the Author], must fulfil the demands of the idea and must not want anything more, the Author must not impose his will – he may only show what he sees himself, creating a perspective, opening, or at least wanting to open a window on the same apparent view he sees. The ability to read enables one to discover and understand the perspective [in the imagination] and experience of others, which are no less true than one’s own – even in everyday and colloquial language, even, for example, when one says that one “reads” a table of analysis results, “to read” means: to understand the intended meaning, to be able to do something with the language of meanings used by the Author.
Reynaldo Gianecchini na revista GQ: um homem feminino que não fere o seu lado masculino
Authors: Abib Roberto , Brasiliense Danielle
Published: September 2023

Ahead of his time, Pepeu Gomes sang about the complexity of gender in the 1980s, and in one of his songs, he claimed that being a feminine man causes no harm to his inner masculine side. Interested in this condition of masculinity, we will seek in this work to bring an analysis of Gentlemen's Quarterly (GQ) magazine and its edition with the actor Reynaldo Gianecchini. We want to understand how GQ builds a narrative link about the life of the celebrity and explores its possible gender fluidity, but which nevertheless reinforces the fundamental ideals of virility. In view of this, and from a Foucauldian methodological perspective on the discourses, we will observe the magazine's narratives that build values that end up reinforcing the importance of saying that it is male.
Difusão de inovações, trabalho e processos de rede no metrô de São Paulo: a experiência da Linha 5-Lilás
Authors: Caiafa Janice
Published: September 2023

The subway system of the city of São Paulo is undergoing a process of full expansion, modernization and privatization of its lines, with the introduction of technological and organizational innovations. In this paper, I present some results of my ethnographic research on the diffusion of innovations (ROGERS, 2003) and networking processes in the São Paulo subway, focusing on the experience of Line 5-Lilac, the first privately operated and modernized existing line. I explore how the association between technological and organizational innovations under the new private appropriation regime restructured subway work, making it multitasking, and how this has been reshaping the daily relations in the communicative circuits of Line 5-Lilac, with effects in the entire subway as a network.
A MEDIAÇÃO COMO VIA DEMOCRATIZANTE DO ACESSO À JUSTIÇA À PESSOA IDOSA
Authors: LARIUCCI HELENA , Cristina Freitas Marques Thais
Published: September 2023

Objetivo: o presente artigo visa a analisar a mediação como via democratizante do acesso à justiça da pessoa idosa, pautando-se na experiência do Núcleo de Mediação da Central Judicial do Idoso – CJI do TJDFT. Método: a pesquisa foi realizada por meio da análise documental e pesquisa bibliográfica e, empiricamente, com base na atuação da CJI. Resultado: concluiu-se que o núcleo especializado, além de pautar-se em princípios e valores relevantes como a pacificação social e o fomento à comunicação não violenta entre as partes, objetiva construir solução adequada ao conflito, garantindo a preservação dos direitos e bem-estar da pessoa idosa. Destaca-se que, mesmo em meio ao contexto de pandemia de Covid-19, a CJI, em 2020, atendeu 258 pessoas e realizou doze acordos e, em 2021, atendeu 846 pessoas e realizou 54 acordos. Os índices ainda apresentaram crescimento em 2022, com 108 acordos (o que corresponde a 77,6%). Dessa forma, a mediação apresenta-se como via adequada de promover o acesso à justiça da pessoa idosa, e a sua utilização em núcleos, como a CJI, apresentou resultados ainda mais positivos, ante a adequação do tratamento para a preservação de direitos, o respeito às potencialidades e às vulnerabilidades desse grupo, a fim de promover a adequada resolução do conflito.
Heterologous expression of P9 from Akkermansia muciniphila improves the GLP-1 secretion of intestinal L cells.
Authors: Di Wenxuan , Zhang Yuchen , zhang xinyuan , Han Luxuan , Zhao Liang , Hao Yanling , Zhai Zhengyuan
Published: September 2023

Glucagon-like peptide-1(GLP-1) is an incretin hormone secreted primarily
from the intestinal L-cells in response to meals. GLP-1 is a key
regulator of energy metabolism and food intake. It has been proven that
P9 protein from A. muciniphila could increase GLP-1 release and improve
glucose homeostasis in HFD-induced mice. To obtain an engineered
Lactococcus lactis which produced P9 protein，mature polypeptide chain
of P9 was codon-optimized, fused with N-terminal signal peptide Usp45,
and expressed in L. lactis NZ9000. Heterologous secretion of P9 by
recombinant L. lactis NZP9 were successfully detected by SDS-PAGE and
western blotting. Notably, the supernatant of L. lactis NZP9 stimulated
GLP-1 production of NCI-H716 cells. The relative expression level of
GLP-1 biosynthesis gene GCG and PCSK1 were upregulated by 1.63 and 1.53
folds, respectively. The engineered strain L. lactis NZP9 was more
effective than A. muciniphila BAA-835 in stimulating the intestinal L
cells to produce GLP-1. To our knowledge, this is the first report on
the secretory expression of carboxyl-terminal processing protease P9
from A. muciniphila in L. lactis. Our results suggest that genetically
engineered L. lactis which expressed P9 may have therapeutic potential
for the treatment of diabetes, obesity and other metabolic disorders.
A Missing Piece of the E-Region Puzzle: The Need for High-Resolution Photoionization Cross Sections and Solar Irradiance in Models
Authors: Soto Emmaris , Evans J. Scott , Meier Robert R. , Tashiro Motomichi , Sakib Md Nazmus , Yigit Erdal
Published: September 2023

Most ionospheric models cannot sufficiently reproduce the observed
electron density profiles in the E-region ionosphere, since they usually
underestimate electron densities. Mitigation of this issue is often
addressed by increasing the solar soft X-ray flux which is ineffective
for resolving data-model discrepancies. We show that low-resolution
cross sections and solar spectral irradiances fail to preserve structure
within the data, which considerably impacts the radiative processes in
the E-region, and are largely responsible for the discrepancies between
observations and simulations. To resolve data-model inconsistencies, we
utilize new high-resolution (0.001 nm) atomic oxygen (O) and molecular
nitrogen (N2) cross sections and solar spectral irradiances, which
preserve autoionization and narrow rotational lines, allowing solar
photons to reach lower altitudes and increase in the photoelectron flux.
This work improves upon Meier et al. (2007) by additionally
incorporating new high-resolution N2 photoionization and photoabsorption
cross sections in model calculations. Model results with the new inputs
show increased O+ production rates of over 500%, larger than those of
Meier et al. (2007) at 0.1 nm resolution, and total ion production rates
of over 125%, while N2+ production rates decrease by ∼15% 30 in the
E-region in comparison to the results obtained using the cross section
compilation from Conway (1988). Low-resolution molecular oxygen (O2)
cross sections from the Conway (1988) compilation are utilized for all
input cases and indicate that O2+ is a dominant contributor to the total
ion production rate in the E-region. Specifically, the photoionization
contributed by longer wavelengths is a main contributor at ∼120 km.
Intersatellite Comparisons of GOES Magnetic Field Measurements
Authors: Rich Frederick , Califf Samuel T , Loto'aniu Paul T.M. , Coakley Monica , Krimchansky Alexander , Singer Howard J.
Published: September 2023

GOES-16 and GOES-17 are the first of NOAA’s Geostationary Operational
Environmental Satellite (GOES)-R series of satellites. Each GOES-R
satellite has a magnetometer mounted on the end (outboard) and one
part-way down a long boom (inboard). This paper demonstrates the
relative accuracy and stability of the measurements on a daily and
long-term basis. The GOES-16 and GOES-17 magnetic field observations
from 2017 to 2020 have been compared to simultaneous magnetic field
observations from each other and from the previous GOES-NOP series
satellites (GOES-13, GOES-14 and GOES-15). These comparisons provide
assessments of relative accuracy and stability. We use a field model to
facilitate the inter-satellite comparisons at different longitudes.
GOES-16 inboard and outboard magnetometers data suffer daily variations
which cannot be explained by natural phenomena. Long-term averaged
GOES-16 outboard (OB) data has daily variations of ± 3 nT which are
stable within ± 1.5 nT. Long-term averaged GOES-17OB magnetometer data
have minimal daily variations (less than ± 1 nT). Daily average of the
difference between the GOES-16 outboard or GOES-17 outboard measurements
and the measurements made by another GOES satellite are computed. The
long-term averaged results show the GOES-16OB and GOES-17OB measurements
have long-term stability (± 2 nT or less) and match measurements from
magnetometers on other GOES within limits stated herein. The GOES-17OB
operational offset (zero field value) was refined using the GOES-17
satellite rotated 180° about the Earth pointing axis (known as a yaw
flip).
Can we distinguish conventional osteosarcoma subtypes (osteoblastic and chondroblastic) based on their magnetic resonance signal intensities?
Authors: Gülçin Bozbeyoğlu Sabriye , Yildirim Ayse Nur
Published: September 2023

Introduction/Objectives. Osteosarcoma is the most common primary malignant bone tumor in adolescents and young adults, with a tendency to produce variable amounts of osteoid, cartilage, and fibrous matrices. The objective of this study is to differentiate between osteosarcoma subtypes: osteoblastic and chondroblastic according to their magnetic resonance imaging (MRI) signal intensities and X-ray findings. Methods. We performed a retrospective analysis for 21 pathologically proven osteosarcoma subtypes: osteoblastic (n = 14) and chondroblastic (n = 7). Conventional images of the bone of origin, periosteal reactions, lytic and sclerotic features, the presence of calcification, and pathological fractures were investigated with X-rays. We measured the mean region of interest values for each lesion with MRI sequences. Results. Among the osteosarcoma lesions, 57% were localized at the knee. X-ray evaluations of the osteoblastic osteosarcomas revealed pure lytic lesions in 35.7%, and pure sclerotic lesions in 42.9% cases. Chondroblastic osteosarcomas revealed pure lytic lesions in 14.3% and pure sclerotic lesions in 42.9% cases. Due to variable osteoblastic, chondroblastic, and fibroblastic areas and proportions of the ossified matrix, osteosarcoma lesions have a heterogeneous MRI signal. However, no statistically significant value was detected. Conclusion. According to our results, MRI signal characteristics and X-ray findings may not be able to distinguish osteosarcoma subtypes, so prospective studies with larger patient cohorts are needed.