bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement
Authors: Kronenberg Florian , Mora Samia , Stroes Erik S G , Ference Brian A , Arsenault Benoit J , Berglund Lars , Dweck Marc R , Koschinsky Marlys , Lambert Gilles , Mach François , McNeal Catherine J , Moriarty Patrick M , Natarajan Pradeep , Nordestgaard Børge G , Parhofer Klaus G , Virani Salim S , von Eckardstein Arnold , Watts Gerald F , Stock Jane K , Ray Kausik K , Tokgözoğlu Lale S , Catapano Alberico L
Published: August 2022

This 2022 European Atherosclerosis Society lipoprotein(a) [Lp(a)] consensus statement updates evidence for the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis, provides clinical guidance for testing and treating elevated Lp(a) levels, and considers its inclusion in global risk estimation. Epidemiologic and genetic studies involving hundreds of thousands of individuals strongly support a causal and continuous association between Lp(a) concentration and cardiovascular outcomes in different ethnicities; elevated Lp(a) is a risk factor even at very low levels of low-density lipoprotein cholesterol. High Lp(a) is associated with both microcalcification and macrocalcification of the aortic valve. Current findings do not support Lp(a) as a risk factor for venous thrombotic events and impaired fibrinolysis. Very low Lp(a) levels may associate with increased risk of diabetes mellitus meriting further study. Lp(a) has pro-inflammatory and pro-atherosclerotic properties, which may partly relate to the oxidized phospholipids carried by Lp(a). This panel recommends testing Lp(a) concentration at least once in adults; cascade testing has potential value in familial hypercholesterolaemia, or with family or personal history of (very) high Lp(a) or premature ASCVD. Without specific Lp(a)-lowering therapies, early intensive risk factor management is recommended, targeted according to global cardiovascular risk and Lp(a) level. Lipoprotein apheresis is an option for very high Lp(a) with progressive cardiovascular disease despite optimal management of risk factors. In conclusion, this statement reinforces evidence for Lp(a) as a causal risk factor for cardiovascular outcomes. Trials of specific Lp(a)-lowering treatments are critical to confirm clinical benefit for cardiovascular disease and aortic valve stenosis.
Dapagliflozin for heart failure according to body mass index: the DELIVER trial
Authors: Adamson Carly , Kondo Toru , Jhund Pardeep S , de Boer Rudolf A , Cabrera Honorio Jose Walter , Claggett Brian , Desai Akshay S , Alcocer Gamba Marco Antonio , Al Habeeb Waleed , Hernandez Adrian F , Inzucchi Silvio E , Kosiborod Mikhail N , Lam Carolyn S P , Langkilde Anna Maria , Lindholm Daniel , Bachus Erasmus , Litwin Sheldon E , Martinez Felipe , Petersson Magnus , Shah Sanjiv J , Vaduganathan Muthiah , Nguyen Vinh Pham , Wilderäng Ulrica , Solomon Scott D , McMurray John J V
Published: August 2022

Aims

Obesity is common and associated with unique phenotypic features in heart failure with preserved ejection fraction (HFpEF). Therefore, understanding the efficacy and safety of new therapies in HFpEF patients with obesity is important. The effects of dapagliflozin were examined according to body mass index (BMI) among patients in the Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure trial.

Methods and results

Body mass index was analysed by World Health Organization (WHO) categories and as a continuous variable using restricted cubic splines. Body mass index ranged from 15.2 to 50 kg/m2 with a mean value of 29.8 (standard deviation ± 6.1) kg/m2. The proportions, by WHO category, were: normal weight 1343 (21.5%); overweight 2073 (33.1%); Class I obesity 1574 (25.2%); Class II obesity 798 (12.8%); and Class III obesity 415 (6.6%). Compared with placebo, dapagliflozin reduced the risk of the primary outcome to a similar extent across these categories: hazard ratio (95% confidence interval): 0.89 (0.69–1.15), 0.87 (0.70–1.08), 0.74 (0.58–0.93), 0.78 (0.57–1.08), and 0.72 (0.47–1.08), respectively (P-interaction = 0.82). The placebo-corrected change in Kansas City Cardiomyopathy Questionnaire total symptom score with dapagliflozin at 8 months was: 0.9 (−1.1, 2.8), 2.5 (0.8, 4.1), 1.9 (−0.1, 3.8), 2.7 (−0.5, 5.8), and 8.6 (4.0, 13.2) points, respectively (P-interaction = 0.03). The placebo-corrected change in weight at 12 months was: –0.88 (−1.28, –0.47), –0.65 (−1.04, –0.26), –1.42 (−1.89, –0.94), –1.17 (−1.94, –0.40), and –2.50 (−4.4, –0.64) kg (P-interaction = 0.002).

Conclusions

Obesity is common in patients with HFpEF and is associated with higher rates of heart failure hospitalization and worse health status. Treatment with dapagliflozin improves cardiovascular outcomes across the spectrum of BMI, leads to greater symptom improvement in patients with obesity, compared with those without, and has the additional benefit of causing modest weight loss.
Effectiveness and safety of mexiletine in patients at risk for (recurrent) ventricular arrhythmias: a systematic review
Authors: van der Ree Martijn H , van Dussen Laura , Rosenberg Noa , Stolwijk Nina , van den Berg Sibren , van der Wel Vincent , Jacobs Bart A W , Wilde Arthur A M , Hollak Carla E M , Postema Pieter G
Published: August 2022

Aims

While mexiletine has been used for over 40 years for prevention of (recurrent) ventricular arrhythmias and for myotonia, patient access has recently been critically endangered. Here we aim to demonstrate the effectiveness and safety of mexiletine in the treatment of patients with (recurrent) ventricular arrhythmias, emphasizing the absolute necessity of its accessibility.

Methods and results

Studies were included in this systematic review (PROSPERO, CRD42020213434) if the efficacy or safety of mexiletine in any dose was evaluated in patients at risk for (recurrent) ventricular arrhythmias with or without comparison with alternative treatments (e.g. placebo). A systematic search was performed in Ovid MEDLINE, Embase, and in the clinical trial registry databases ClinicalTrials.gov and ICTRP. Risk of bias were assessed and tailored to the different study designs. Large heterogeneity in study designs and outcome measures prompted a narrative synthesis approach. In total, 221 studies were included reporting on 8970 patients treated with mexiletine. Age ranged from 0 to 88 years. A decrease in ventricular arrhythmias of >50% was observed in 72% of the studies for pre-mature ventricular complexes, 64% for ventricular tachycardia, and 33% for ventricular fibrillation. Electrocardiographic effects of mexiletine were small; only in a subset of patients with primary arrhythmia syndromes, a relative (desired) QTc decrease was reproducibly observed. As for adverse events, gastrointestinal complaints were most frequently observed (33% of the patients).

Conclusions

In this systematic review, we present all the currently available knowledge of mexiletine in patients at risk for (recurrent) ventricular arrhythmias and show that mexiletine is both effective and safe.
The challenge of managing multimorbid atrial fibrillation: a pan-European European Heart Rhythm Association (EHRA) member survey of current management practices and clinical priorities
Authors: Lee Geraldine , Baker Edward , Collins Ronan , Merino Jose L , Desteghe Lien , Heidbuchel Hein
Published: August 2022

As part of the EHRS-PATHS study examining comorbidities in atrial fibrillation (AF) across Europe, the aim was (i) to evaluate how multimorbidity is currently addressed by clinicians during AF treatment to characterize the treatment structure and (ii) to assess how the interdisciplinary management of multimorbid AF is currently conducted. An online survey was distributed among European Heart Rhythm Association (EHRA) members in Europe that included 21 questions and a free-text option for comments on detection, assessment, and management of AF-related comorbidities. A total of 451 responses were received with 339 responses eligible for inclusion. Of these, 221 were male (66%), 300 (91.5%) were physicians, and 196 (57.8%) were working in academic university teaching hospitals. Half of the respondents managed between 20 and 50 patients per month with multimorbid AF. Varying rates of specialist services and referral to these services were available at each location (e.g. heart failure and diabetes), with a greater number of specialist services available at academic university teaching hospitals compared with non-teaching hospitals [e.g. anticoagulation clinic 92 (47%) vs. 50 (35%), P < 0.03]. Barriers to referring to specialist services for AF comorbidities included lack of integrated care model (n = 174, 51%), organizational or institutional issues (n = 145, 43%), and issues with patient adherence (n = 126, 37%), highlighting the need for organizational restructuring and developing an integrated collaborative evidenced-based approach to multimorbid AF care. The survey and analyses of free-text comments demonstrated the need for systematic, integrated management of AF-related comorbidities, and these results will inform the next phases of the EHRA-PATHS study.
P07-02 Prescription of adapted physical activity: expectations of patients consulting general practitioners in the department of Yvelines
Authors: Kanso Christophe , Blanchard Jean-Christophe , Astruc Alexis
Published: August 2022

Background

Since 2016, French law has allowed general practitioners to prescribe adapted physical activity (APA) to patients with long-term health conditions. Studies have demonstrated that physicians are interested in this practice but very few have surveyed patient expectations.

Objective

The objective of this work was to study patients' expectations regarding the prescription of APA.

Methods

This is a quantitative descriptive study treating data obtained from a survey carried out in general practice offices in the department of Yvelines between June and September 2019. The inclusion criteria for patients were: above 18 years old and present in the waiting room.

Results

252 patients were surveyed in 9 doctors' offices. We received 90% of responses. Prescription of APA is a good idea for 95.2% of patients, 80.2% were motivated to join an APA program and 67.4% thought that prescription of APA would increase their motivation. The main constraints to physical activity practice were lack of time (59.9%) and lack of motivation (31.7%). The main practices that would help patients to better adhere to an APA program were group sessions supervised by a professional (64.7%) pursued by a follow up with their doctor (41.7%). 53.2% of patients considered that it would be important to monitor their physical activity through a connected device. Factors independently associated with the motivation to participate in the APA program were a female gender (p > 0.01), a bachelor's degree (p = 0.01), a general opinion that prescription of physical activity is a good idea (p > 0.01).

Conclusion

Our results revealed an enthusiasm with patients for APA prescription, which is interesting for the promotion of PA in general medicine.
Impact of hypothetical improvements in the psychosocial work environment on sickness absence rates: a simulation study
Authors: Mathisen Jimmi , Nguyen Tri-Long , Jensen Johan H , Mehta Amar J , Rugulies Reiner , Rod Naja H
Published: August 2022

Background

The association between psychosocial working environments and sickness absence is well-known. However, the potential for reducing sickness absences of different lengths through improvements in psychosocial work factors is not fully understood. We aim to quantify the potential for reducing short-, intermediate- and long-term sickness absence rates, respectively, through hypothetical improvements in several psychosocial work factors.

Methods

This longitudinal study includes 24 990 public hospital employees from the 2014 wave of the Well-being in Hospital Employees study. The 1-year sickness absence rate was divided into short- (1–3 days), intermediate- (4–28 days) and long-term (29 days or more) periods. We simulated hypothetical scenarios with improvements in 17 psychosocial work factors using the parametric g-formula and estimated resulting changes in sickness absence rate ratios (RRs) with 95% confidence intervals (95% CIs).

Results

Setting all 17 psychosocial work factors to their most desirable levels (vs. least desirable levels) was associated with an overall 54% lower rate of sickness absence (95% CI: 48–60%). Reducing bullying (no vs. yes RR: 0.86, 95% CI: 0.83–0.90) and perceived stress (low vs. high RR: 0.90, 95% CI: 0.87–0.92), and increasing skill discretion (high vs. low RR: 0.91, 95% CI: 0.89–0.94) held the largest potential for reducing the total sickness absence rate. Overall, associations were similar for short-, intermediate- and long-term sickness absence.

Conclusions

The psychosocial working environment was strongly associated with sickness absence. Improving the working environment may have a great impact on short-, intermediate- and long-term sickness absence rates.
Ottowia massiliensissp. nov., a new bacterium isolated from a fresh, healthy human fecal sample
Authors: Maaloum Mossaab , Lo Cheikh Ibrahima , Ndongo Sokhna , Meng Marine Makoa , Saile Rachid , Alibar Stéphane , Raoult Didier , Fournier Pierre-Edouard
Published: August 2022

The culturomics method enabled isolation of a new member of the Ottowia genus from the stool sample of a healthy volunteer. Strain Marseille-P4747T exhibited a 96.18% 16S rRNA sequence identity with Ottowia beijingensis strain GCS-AN-3 (NR_133803.1), the closest species with standing in nomenclature. It is a Gram-stain-negative, nonmotile, and aerobic bacterium. It does not possess catalase and oxidase activities. Its genome has a size of 2 830 447 bp and a G + C content of 63.5 mol%. Based on the phylogenic, phenotypic, and genomic analyses, we conclude that Ottowia massiliensis sp. nov. is a new species, represented by Marseille-P4747T ( = CSUR P4747 = CECT 30348) as type strain.
Political Leaders, Economic Hardship, and Foreign Aid Allocation
Authors: Kim Yooneui , Han Kangwook , Han Sung Min
Published: August 2022

While political leaders’ role in foreign policy choices has received increasing scholarly attention, surprisingly less is known about how they affect the allocation and distribution of official development aid. This study examines how the material background of political leaders influences their aid allocation strategies in donor countries. We contend that leaders with economic hardship experience distribute more foreign aid than those without such experience. Through socialization, leaders with economic hardship experience become more supportive of public good provisions that address problems related to poverty and inequality. Resultantly, they exhibit more favorable attitudes toward development assistance programs targeting developing countries. We find that political leaders who experienced economic difficulty in their youth are likely to provide more foreign aid, especially social and economic infrastructure aid, than leaders without such experience. By introducing the political leaders’ role, this study contributes to the literature on the interaction between domestic politics and foreign aid.
Brain Changes and Fast Cognitive and Motor Decline in Older Adults
Authors: Grande Giulia , Vetrano Davide Liborio , Kalpouzos Grégoria , Welmer Anna-Karin , Laukka Erika J , Marseglia Anna , Fratiglioni Laura , Rizzuto Debora
Published: August 2022

Background

To identify brain magnetic resonance imaging (MRI) signatures characterizing people with different patterns of decline in cognition and motor function.

Methods

In the Swedish National Study on Aging and Care in Kungsholmen, Stockholm, 385 participants had available repeated brain MRI examinations, where markers of brain volumes and white matter integrity were assessed. The speed of cognitive and motor decline was estimated as the rate of a Mini-Mental State Examination and gait speed decline over 12 years (linear mixed models), and further dichotomized into the upper (25% fastest rate of decline) versus the lower quartiles. Participants were grouped in slow/no decliners (reference), isolated motor decliners, isolated cognitive decliners, and cognitive and motor decliners. We estimated the associations between changes in brain markers (linear mixed models) and baseline diffusion tensor imaging measures (linear regression model) and the 4 decline patterns.

Results

Individuals with concurrent cognitive and motor decline (n = 51) experienced the greatest loss in the total brain (β: −12.3; 95% confidence interval [CI]: −18.2; −6.38) and hippocampal (β: −0.25; 95% CI: −0.34; −0.16) volumes, the steepest accumulation of white matter hyperintensities (β: 1.61; 95% CI: 0.54; 2.68), and the greatest ventricular enlargement (β: 2.07; 95% CI: 0.67; 3.47). Compared to the reference, those only experiencing cognitive decline presented with steeper hippocampal volume loss, whereas those exhibiting only motor decline displayed a greater white matter hyperintensities burden. Lower microstructural white matter integrity was associated with concurrent cognitive and motor decline.

Conclusion

Concurrent cognitive and motor decline is accompanied by rapidly evolving and complex brain pathology involving both gray and white matter. Isolated cognitive and motor declines seem to exhibit brain damage with different qualitative features.
mecCMRSA in Israel—genomic analysis, prevalence and global perspective
Authors: Baum Moti , Anuka Einav , Treygerman Orit , Prajgrod George , Valinsky Lea , Rokney Assaf
Published: August 2022

Background

MRSA is a major global healthcare problem. In 2011, a new mec variant designated mecC was described, presenting partial identity at the DNA level, thus undetectable by routine mecA PCR.

Objectives

Until now, no reliable information regarding mecC MRSA prevalence was available in Israel. In this study, to the best of our knowledge, we describe the first case of mecC MRSA in Israel, with focus on genomic analysis and global context.

Methods

The mecC MRSA isolate was analysed by WGS with focus on phylogeny, global contextualization, virulence and resistance genes. The strain was characterized by antibiotic susceptibility testing, spa typing and presence of mecA/C and pvl genes.

Results

An MRSA strain (SA10610), isolated from a urine sample of an 83-year old patient, was found negative for the mecA and pvl genes. The MLST and spa type were ST130 and t1736, respectively. SA10610 presented resistance to oxacillin, penicillin and cefoxitin, and susceptibility to all non-β-lactam agents tested. Phylogenetic comparison with a global dataset of 586 mecC MRSA genomes revealed substantial genomic divergence. The nearest genomic relatives were human and animal isolates from Denmark. A screen of 12 761 S. aureus isolates collected during 2011–18 in Israel indicated this is the only mecC-positive strain.

Conclusions

A high degree of genetic variability was found between the SA10610 strain and previously sequenced mecC MRSA isolated worldwide. The genomic and phylogenetic analysis suggest that mecC MRSA isolates have evolved independently rather than from a common ancestor.
Digestible indispensable amino acid scores of animal and plant ingredients potentially used in dog diet formulation: how this protein quality metric is affected by ingredient characteristics and reference amino acid profile
Authors: Templeman James R , Shoveller Anna K
Published: August 2022

The ability of a diet or an ingredient to satisfy the indispensable amino acid (IAA) requirements of an individual is a reflection of protein quality (PQ). The concept of PQ is gaining recognition in the pet food industry as a way to identify candidate ingredients for diet formulation. The objective of this report was to use IAA digestibility data from swine and cecectomized rooster assays to generate digestible IAA scores (defined herein as DIAAS-like values) to predict the PQ of ingredients used in dog diets. However, as PQ equation development relies on a reference IAA profile, which is intended to be based on the physiological requirements of a specific population, we sought to generate DIAAS-like values using IAA requirements established by the National Research Council (NRC) as well as practical IAA recommendations presented by the Association of American Feed Control Officials (AAFCO) and European Pet Food Industry Federation (FEDIAF), to assess how these profiles may affect PQ. In total, 30 animal (75 unique inputs) and 27 plant ingredients (94 unique inputs) satisfied all inclusion criteria to be used in the final data set. Ingredients were initially categorized as animal or plant, and further categorized based on AAFCO Official Common and Usual Names and Definitions of Feed Ingredients to allow for additional, more distinct comparisons to be made. Data were analyzed using PROC GLIMMIX in SAS, with ingredient reference as a random effect, and ingredient category, regulatory body, and life stage as fixed effects. As expected, differences were observed in DIAAS-like values for nearly all ingredients and ingredient categories when determined using NRC, AAFCO, or FEDIAF IAA requirements or recommendations as the reference pattern. Moreover, applying reference patterns based on NRC adult maintenance IAA requirements consistently produced the lowest DIAAS-like values. Ultimately, while future studies assessing PQ should utilize NRC minimal requirements, individual ingredient and ingredient category differences in DIAAS-like values when using AAFCO and FEDIAF recommendations underpin the different regulatory approaches to establishing dietary nutrient recommendations that exist globally and support the need for harmonization of dietary recommendations.
The Evolution and Emergence of Environmental Law Scholarship—A Perspective from Three Journals
Authors: Pedersen Ole W
Published: August 2022

In the attempt to lay the foundations for a better understanding of environmental law scholarship, this article offers a local perspective of environmental law scholarship in the UK. Through a study of more than 1,400 articles published in three leading UK environmental law journals over the course of three decades, the article considers the ways in which environmental law scholarship has changed over time by reference to gender and geographical location of authors. The article also interrogates the ways in which the topics of scholarship have changed over time, as well as the extent to which environmental law scholars make use of empirical methods and external sources of funding for their research. Finally, the article explores the extent to which environmental law scholarship is published in generalist law journals.
Advocating for the Environment, Charity Law and Greenpeace: A New Zealand Perspective
Authors: Chevalier-Watts Juliet
Published: August 2022

In terms of environmental protection (and with reference to the filming location of the Lords of the Rings), New Zealand has been described as ‘a friend to Middle Earth, but no friend of the Earth’, which is in stark contrast to its international image that it seeks to foster of being ‘100% pure New Zealand’. This article considers the tension between New Zealand’s approach to environmental advocacy from a charity law perspective, and in particular, the way in which charitable advocacy for the environment has been impacted by the limitations imposed on environmental charities through the charity law doctrine of political purposes. In carrying out this analysis, the article tracks the legal evolution of this doctrine and considers whether recent legal changes have resulted in charity law enabling New Zealand to become ‘a friend to Middle Earth, and a friend of the Earth’ through the apparent broadening of the actions that can be taken by environmental charity advocates.
Juglans mandshurica Maximowicz as a traditional medicine: review of its phytochemistry and pharmacological activity in East Asia
Authors: Zhao Chengye , Qian Xunjia , Qin Minni , Sun Xinyang , Yu Qingqing , Liu Jianyu , Zhu Qing , Wang Andong
Published: August 2022

Objectives

The conducted search reveals that Juglans mandshurica Maximowicz, called Manchuria walnuts, had many local uses that can be categorized into cancer, dermatosis and acesodyne.

Key findings

Various metabolites including diarylheptanoids, naphthoquinones, and flavonoids (also their glycosides) were reported as bioactive metabolites. The isolated metabolites and extracts from J. mandshurica showed different biological activity including cytotoxicity, anti-inflammation, antimelanotic, anticomplement, anti-HIV, antimicrobial and anti-obesity activity.

It is indicated that this review will add value to more scientific research on J. mandshurica and enhance the increased interest in the sustainable commercialization of J. mandshurica. It also leads to the validation of unverified ethnobotanical claims. Future studies on J. mandshurica would be focused to establish the links between the pharmacological activity, bioactive metabolites, and traditional uses.
Urban microclimate warming improves overwintering survival of evergreen bagworms
Authors: Dawadi Sujan , Sadof Clifford S
Published: August 2022

In the northernmost latitude of North America, the evergreen bagworm, Thyridopteryx ephemeraeformis (Haworth), distribution is limited by overwintering temperatures. Urban impervious surfaces such as roads, buildings and parking lots can warm microclimates and create ecological temperature gradients that have the potential to increase the winter survival of insects. To test this hypothesis, we evaluated survival of bagworms over gradients of microclimatic conditions. Bagworms live within spindle-shaped bags constructed from fragments of foliage. In late summer, adult male bagworms fly to bags containing wingless adult females. Mated neotenous females lay eggs within their pupal case. These eggs hatch into larvae during the late spring of the following year and disperse to hosts by ballooning. A total of 2255 bagworm bags were collected from 119 sites in Indiana and Illinois prior to egg hatch in the spring of 2018 and 2019. The maximum temperature during the coldest days of winter was recorded at each site. Up to 25 bagworms were removed from each host plant to assess the overwintering survival of eggs. Survivorship rose as estimates of impervious surface within a 20-m radius increased. Specifically, 50% of bagworm eggs survived at maximum daily temperatures of −19.4°C, −20°C and −20.6°C when plants were surrounded by 25.7%, 48.39% and 50.75% impervious surface, respectively. Egg mortality was not buffered by impervious surfaces at temperatures at or below −21.67°C. Our findings provide insights about how impervious surface in urban areas can provide refugia for marginally hardy insects and improve their chances of surviving the cold of winter.
Associations Between Sociodemographic, Mental Health, and Mild Traumatic Brain Injury Characteristics With Lifetime History of Criminal Justice Involvement in Combat Veterans and Service Members
Authors: Gius Becky K , Fournier Lauren F , Reljic Tea , Pogoda Terri K , Corrigan John D , Garcia Amanda , Troyanskaya Maya , Hodges Cooper B , Miles Shannon R
Published: August 2022

Introduction

Veterans and service members (V/SM) may have more risk factors for arrest and felony incarceration (e.g., posttraumatic stress disorder and at-risk substance use) but also more protective factors (e.g., access to health care) to mitigate behaviors that may lead to arrest. As such, understanding which factors are associated with criminal justice involvement among V/SM could inform prevention and treatment efforts. The current study examined relationships between lifetime history of arrests and felony incarceration and sociodemographic, psychological, and brain injury characteristics factors among combat V/SM.

Materials and Methods

The current study was a secondary data analysis from the Chronic Effects of Neurotrauma Consortium multicenter cohort study, approved by local institutional review boards at each study site. Participants were V/SM (N = 1,540) with combat exposure (19% active duty at time of enrollment) who were recruited from eight Department of Veterans Affairs and DoD medical centers and completed a baseline assessment. Participants were predominantly male (87%) and white (72%), with a mean age of 40 years (SD = 9.7). Most (81%) reported a history of at least one mild traumatic brain injury, with one-third of those experiencing three or more mild traumatic brain injuries (33%). Participants completed a self-report measure of lifetime arrest and felony incarceration history, a structured interview for all potential concussive events, the post-traumatic stress disorder checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and the Alcohol Use Disorders Identification Test-Consumption. Three groups were compared on self-reported level of lifetime history of criminal justice system involvement: (1) no history of arrest or incarceration (65%); (2) history of arrest but no felony incarceration (32%); and (3) history of felony incarceration (3%).

Results

Ordinal regression analyses revealed that hazardous alcohol consumption (β = .44, P < .001; odds ratio = 1.56) was positively associated with increased criminal justice involvement after adjusting for all other variables. Being married or partnered (β = −.44, P < .001; odds ratio = 0.64) was negatively associated with decreased criminal justice involvement.

Conclusions

The rate of lifetime arrest (35%) in this V/SM sample was consistent with rates of arrests in the U.S. general population. One modifiable characteristic associated with lifetime arrest and felony incarceration was hazardous alcohol consumption. Alcohol use should be a top treatment target for V/SM at risk for arrest and those with history of criminal justice involvement.
SARS-CoV-19-associated Rhino-orbital and cerebral mucormycosis: clinical and radiological presentations
Authors: Mittal Ashima , Mahajan Nitika , Pal Singh Dhanota Devinder , Paul Birinder S , Ahluwalia Srishti , Ahluwalia Saumya , Galhotra Arnav , Gupta Veenu , Puri Sanjeev , Verma Rohit , Munjal Manish , Goel Sahil , Chopra Sumeet , Mahajan Rajesh , Ahluwalia Archana , Saggar Kavita , Singh Gagandeep
Published: August 2022

We describe presenting clinical and imaging manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated Rhino-oculo-cerebral mucormycosis (ROCM) in a hospital setting during the second wave of SARS-CoV-2 pandemic in India. Data on the presenting manifestations were collected from 1 March to 31 May 2021. Associations between clinical and imaging findings were explored, specifically: (1) the presence or absence of orbital pain and infiltration of a superior orbital fissure on imaging; (2) the presence of unilateral facial nerve palsy and pterygopalatine fossa infiltration and geniculate ganglion signal on contrast magnetic resonance imaging, and (3) vision loss and optic nerve findings on imaging. Orbital pain was reported by 6/36 subjects. A fixed, frozen eye with proptosis and congestion was documented in 26 (72%), complete vision loss in 23 (64%), and a unilateral lower motor neuron facial nerve palsy in 18 (50%). No association was found between the presence of orbital pain and superior orbital fissure infiltration on imaging. The ipsilateral geniculate ganglion was found to enhance more profoundly in 7/11 subjects with facial palsy and available magnetic resonance (MR) imaging, and the ipsilateral pterygopalatine fossa was found infiltrated in 14. Among 23 subjects with complete loss of vision, 9 (39%) demonstrated long-segment bright signal in the posterior optic nerve on diffusion MR images. We conclude that orbital pain might be absent in SARS-CoV-2-associated ROCM. Facial nerve palsy is more common than previously appreciated and ischemic lesions of the posterior portion of the optic nerve underlie complete vision loss.
The effects of local stellar radiation and dust depletion on non-equilibrium interstellar chemistry
Authors: Richings Alexander J , Faucher-Giguère Claude-André , Gurvich Alexander B , Schaye Joop , Hayward Christopher C
Published: August 2022

Interstellar chemistry is important for galaxy formation, as it determines the rate at which gas can cool, and enables us to make predictions for observable spectroscopic lines from ions and molecules. We explore two central aspects of modelling the chemistry of the interstellar medium (ISM): (1) the effects of local stellar radiation, which ionizes and heats the gas, and (2) the depletion of metals on to dust grains, which reduces the abundance of metals in the gas phase. We run high-resolution (400 M⊙ per baryonic particle) simulations of isolated disc galaxies, from dwarfs to Milky Way-mass, using the fire galaxy formation models together with the chimes non-equilibrium chemistry and cooling module. In our fiducial model, we couple the chemistry to the stellar fluxes calculated from star particles using an approximate radiative transfer scheme; and we implement an empirical density-dependent prescription for metal depletion. For comparison, we also run simulations with a spatially uniform radiation field, and without metal depletion. Our fiducial model broadly reproduces observed trends in H i and H2 mass with stellar mass, and in line luminosity versus star formation rate for [C ii]$_{158 \rm {\mu m}}$, [O i]$_{63 \rm {\mu m}}$, [O iii]$_{88 \rm {\mu m}}$, [N ii]$_{122 \rm {\mu m}}$, and H α6563Å. Our simulations with a uniform radiation field predict fainter luminosities, by up to an order of magnitude for [O iii]$_{88 \rm {\mu m}}$ and H α6563Å, while ignoring metal depletion increases the luminosity of carbon and oxygen lines by a factor ≈ 2. However, the overall evolution of the galaxy is not strongly affected by local stellar fluxes or metal depletion, except in dwarf galaxies where the inclusion of local fluxes leads to weaker outflows and hence higher gas fractions.
The H i gas disc thickness of the ultra-diffuse galaxy AGC 242019
Authors: Li Xin , Shi Yong , Zhang Zhi-Yu , Chen Jianhang , Yu Xiaoling , Wang Junzhi , Gu Qiusheng , Li Songlin
Published: August 2022

Ultra-diffuse galaxies (UDGs) are as faint as dwarf galaxies but whose sizes are similar to those of spiral galaxies. A variety of formation mechanisms have been proposed, some of which could result in different disc thicknesses. In this study, we measure the radial profile of the H i scale height (hg) and flaring angle (hg/R) of AGC 242019 through the joint Poisson–Boltzmann equation based on its well spatially-resolved H i gas maps. The mean H i scale height of AGC 242019 is $\langle h_{\rm g}\rangle \approx 537.15 \pm 89.4\,{\rm pc}$, and the mean flaring angle is $\langle h_{\rm g}/R \rangle\approx 0.19 \pm 0.03$. As a comparison, we also derive the disc thickness for a sample of 14 dwarf irregulars. It is found that the H i disc of AGC 242019 has comparable thickness to dwarfs. This suggests that AGC 242019 is unlikely to experience much stronger stellar feedback than dwarf galaxies, which otherwise leads to a thicker disc for this galaxy.
High mass flow rate in a BAL outflow of quasar SDSS J1130 + 0411
Authors: Walker Andrew , Arav Nahum , Byun Doyee
Published: August 2022

We present the analysis of the absorption troughs of six outflows observed in quasar SDSS J1130 + 0411 ($z$ ≈ 3.98) with radial velocities ranging from −2400 to $-15\, 400$ km s−1. These spectra were taken with the Very Large Telescope/Ultraviolet and Visual Echelle Spectrograph over the rest-frame wavelength range of 1135–1890 Å. In the main outflow system ($v$ ≈ −3200 km s−1), we identify Fe ii and several Fe ii* absorption troughs, as well as Si ii and Si ii* troughs, which we use to determine the electron number density $\log n_e = 2.6_{-0.7}^{+0.8}$ cm−3. Using the column densities of these and other ions, we determine a photoionization solution with hydrogen column density $\log N_H = 21.44_{-0.33}^{+0.24}$ cm−2 and ionization parameter $\log U_H = -1.75_{-0.45}^{+0.28}$. From these values, we derive the distance $R = 16_{-11}^{+23}$ kpc, the average mass flow rate $\dot{M} = 4100_{-2400}^{+6600}$ M⊙ yr−1, and the kinetic luminosity $\log \dot{E}_k = 46.13_{-0.37}^{+0.41}$ erg s−1. This $\dot{E}_k$ is $1.4_{-0.8}^{+2.2}$ per cent of the quasar’s Eddington luminosity, and therefore contributes significantly to AGN feedback.
ATOMS: ALMA three-millimeter observations of massive star-forming regions – XII: Fragmentation and multiscale gas kinematics in protoclusters G12.42+0.50 and G19.88−0.53
Authors: Saha Anindya , Tej Anandmayee , Liu Hong-Li , Liu Tie , Issac Namitha , Lee Chang Won , Garay Guido , Goldsmith Paul F , Juvela Mika , Qin Sheng-Li , Stutz Amelia , Li Shanghuo , Wang Ke , Baug Tapas , Bronfman Leonardo , Xu Feng-Wei , Zhang Yong , Eswaraiah Chakali
Published: August 2022

We present new continuum and molecular line data from the ALMA Three-millimeter Observations of Massive Star-forming regions (ATOMS) survey for the two protoclusters, G12.42+0.50 and G19.88−0.53. The 3 mm continuum maps reveal seven cores in each of the two globally contracting protoclusters. These cores satisfy the radius–mass relation and the surface mass density criteria for high-mass star formation. Similar to their natal clumps, the virial analysis of the cores suggests that they are undergoing gravitational collapse ($\rm \alpha _{vir} \lt \lt 2$). The clump to core scale fragmentation is investigated and the derived core masses and separations are found to be consistent with thermal Jeans fragmentation. We detect large-scale filamentary structures with velocity gradients and multiple outflows in both regions. Dendrogram analysis of the H13CO+ map identifies several branch and leaf structures with sizes ∼ 0.1 and 0.03 pc, respectively. The supersonic gas motion displayed by the branch structures is in agreement with the Larson power law indicating that the gas kinematics at this spatial scale is driven by turbulence. The transition to transonic/subsonic gas motion is seen to occur at spatial scales of ∼0.1 pc indicating the dissipation of turbulence. In agreement with this, the leaf structures reveal gas motions that deviate from the slope of Larson’s law. From the large-scale converging filaments to the collapsing cores, the gas dynamics in G12.42+0.50 and G19.88−0.53 show scale-dependent dominance of turbulence and gravity and the combination of these two driving mechanisms needs to be invoked to explain massive star formation in the protoclusters.
E
iso–Ep correlation of gamma-ray bursts: calibration and cosmological applications
Authors: Jia X D , Hu J P , Yang J , Zhang B B , Wang F Y
Published: August 2022

Gamma-ray bursts (GRBs) are the most explosive phenomena and can be used to study the expansion of Universe. In this paper, we compile a long GRB sample for the Eiso–Ep correlation from Swift and Fermi observations. The sample contains 221 long GRBs with redshifts from 0.03 to 8.20. From the analysis of data in different redshift intervals, we find no statistically significant evidence for the redshift evolution of this correlation. Then we calibrate the correlation in six subsamples and use the calibrated one to constrain cosmological parameters. Employing a piece-wise approach, we study the redshift evolution of dark energy equation of state (EOS), and find that the EOS tends to be oscillating at low redshift, but consistent with −1 at high redshift. It hints at dynamical dark energy at 2σ confidence level at low redshift.
Acetaldehyde binding energies: a coupled experimental and theoretical study
Authors: Ferrero S , Grieco F , Ibrahim Mohamed A-S , Dulieu F , Rimola A , Ceccarelli C , Nervi C , Minissale M , Ugliengo P
Published: August 2022

Acetaldehyde is one of the most common and abundant gaseous interstellar complex organic molecules found in cold and hot regions of the molecular interstellar medium. Its presence in the gas-phase depends on the chemical formation and destruction routes, and its binding energy (BE) governs whether acetaldehyde remains frozen on to the interstellar dust grains or not. In this work, we report a combined study of the acetaldehyde BE obtained via laboratory temperature programmed desorption (TPD) experiments and theoretical quantum chemical computations. BEs have been measured and computed as a pure acetaldehyde ice and mixed with both polycrystalline and amorphous water ice. Both calculations and experiments found a BE distribution on amorphous solid water that covers the 4000–6000 K range when a pre-exponential factor of $1.1\times 10^{18}\, \mathrm{s}^{-1}$ is used for the interpretation of the experiments. We discuss in detail the importance of using a consistent couple of BE and pre-exponential factor values when comparing experiments and computations, as well as when introducing them in astrochemical models. Based on the comparison of the acetaldehyde BEs measured and computed in the present work with those of other species, we predict that acetaldehyde is less volatile than formaldehyde, but much more than water, methanol, ethanol, and formamide. We discuss the astrochemical implications of our findings and how recent astronomical high spatial resolution observations show a chemical differentiation involving acetaldehyde, which can easily explained due to the different BEs of the observed molecules.
Engine-fed kilonovae (mergernovae) – I. Dynamical evolution and energy injection/heating efficiencies
Authors: Ai Shunke , Zhang Bing , Zhu Zhaohuan
Published: August 2022

A binary neutron star merger is expected to be associated by a kilonova, transient optical emission powered by radioactive decay of the neutron-rich ejecta. If the post-merger remnant is a long-lived neutron star, additional energy injection to the ejecta is possible. In this first paper of a series, we study the dynamical evolution of the engine-fed kilonova (mergernova) ejecta in detail. We perform a semi-analytical study of the problem by adopting a modified mechanical blastwave model that invokes interaction between a Poynting-flux-dominated flow and a non-magnetized massive ejecta. Shortly after the engine is turned on, a pair of shocks would be excited. The reverse shock quickly reaches the wind-acceleration region and disappears (in a few seconds), whereas the forward shock soon breaks out from the ejecta (in 102–103 s) and continues to propagate in the surrounding interstellar medium. Most of the energy injected into the blastwave from the engine is stored as magnetic energy and kinetic energy. The internal energy fraction is fint < 0.3 for an ejecta mass equal to 10−3 M⊙. Overall, the energy injecting efficiency ξ is at most ∼0.6 and can be as small as ∼0.04 at later times. Contrary to the previous assumption, efficient heating only happens before the forward shock breaks out of the ejecta with a heating efficiency ξt ∼ (0.006 − 0.3), which rapidly drops to ∼0 afterwards. The engine-fed kilonova light curves will be carefully studied in Paper II.
Comparing reflection and absorption models for the soft X-ray variability in the NLS1 AGN UGC 11763
Authors: Jiang Jiachen , Gallo Luigi C , Grupe Dirk , Parker Michael L
Published: August 2022

We present a spectral analysis of two XMM–Newton observations of the narrow-line Seyfert 1 galaxy UGC 11763. UGC 11763 shows very different soft X-ray spectral shapes in the two observations separated by 12 yr. Three spectral models are considered to explain the multi-epoch X-ray variability of UGC 11763, one based on the relativistic disc reflection model, one based on multiple partially covering absorbers combined with the warm corona model, and a hybrid model. In the first model, the X-ray variability of UGC 11763 is caused by the emission from a compact coronal region with a variable size. The resulting disc reflection component changes accordingly. A warm absorption model with a modest column density is required in this model too. In the partially covering absorption scenario, the X-ray variability of UGC 11763 is caused by the variable covering factors of two absorbers located within a region of r < ≈100rg. Moreover, the temperature and strength of the warm corona have to change significantly too to explain the variable underlying soft X-ray emission. Lastly, we investigate the possibility of variable intrinsic power-law emission from the hot corona combined with variable absorption in UGC 11763 without changing the geometry of the corona in the third model. This hybrid model provides a slightly better fit than the partially covering absorption model with improvements in fitting the iron emission band. Current CCD-resolution data cannot distinguish these spectral models for UGC 11763. Future high-resolution X-ray missions, e.g. Athena and XRISM, will test them by resolving different spectral components.
A multifidelity emulator for the Lyman-α forest flux power spectrum
Authors: Fernandez M A , Ho Ming-Feng , Bird Simeon
Published: August 2022

In this work, we extend our recently developed multifidelity emulation technique to the simulated Lyman-α forest flux power spectrum. Multifidelity emulation allows interpolation of simulation outputs between cosmological parameters using many cheap low-fidelity simulations and a few expensive high-fidelity simulations. Using a test suite of small-box (30 Mpc h−1) simulations, we show that multifidelity emulation is able to reproduce the Lyman-α forest flux power spectrum well, achieving an average accuracy when compared to a test suite of $0.8\, {\rm {per\ cent}}$. We further show that it has a substantially increased accuracy over single-fidelity emulators, constructed using either the high- or low-fidelity simulations only. In particular, it allows the extension of an existing simulation suite to smaller scales and higher redshifts.
Does locomotive syndrome severity predict future fragility fractures in community-dwelling women with osteoporosis?
Authors: Asahi Ryoma , Nakamura Yutaka , Koike Yoshinao , Kanai Masayoshi , Watanabe Kento , Yuguchi Satoshi , Kamo Tomohiko , Azami Masato , Ogihara Hirofumi , Asano Satoshi
Published: August 2022

Objectives

We investigated whether the locomotive syndrome (LS) severity affects future fragility fractures in osteoporosis patients.

Methods

In this retrospective cohort study, 315 women with osteoporosis (mean follow-up period, 2.8 years) were reviewed, of whom 244 were included in the analysis. At baseline, we obtained medical information, bone mineral density of the lumbar spine and femoral neck, and sagittal vertical axis. Additionally, LS risk was assessed using the two-step test, stand-up test, and 25-question geriatric locomotive function scale scores. The LS risk test results were used to classify LS severity, which was rated on a 4-point scale from stage 0 (robust) to 3 (worsening). Cox proportional hazards regression analysis was used to determine the association of the severity with future fragility fracture.

Results

Fragility fractures occurred in 37 of 315 participants (11.8%). This study showed that sagittal vertical axis (hazard ratio = 1.014; 95% confidence interval, 1.005–1.023; p value = 0.003) and LS severity (hazard ratio =1.748; 95% confidence interval, 1.133–2.699; p = 0.012) were independent risk factors for incidence of fragility fracture.

Conclusions

This study revealed the LS severity to predicted fragility fractures. We suggested that the progression of LS associated with osteoporosis increases the fracture risk.