bluuebunny/crossref_metadata_2025 huggingface dataset:
Quasi-solid-state electrolytes - strategy towards stabilising Li|inorganic solid electrolyte interfaces in solid-state Li metal batteries
Authors: Mazzapioda Lucia , Tsurumaki Akiko , Di Donato Graziano , Adenusi Henry , Navarra Maria Assunta , Passerini Stefano
Published: April 2023

Solid-state batteries (SSBs) based on inorganic solid electrolytes (ISEs) are considered promising candidates for enhancing the energy density and the safety of next-generation rechargeable lithium batteries. However, their practical application is frequently hampered by the high resistance arising at the Li metal anode/ISE interface. Herein, a review of the conventional solid-state electrolytes (SSEs) the recent research on quasi-solid-state battery (QSSB) approaches to overcome the issues of the state-of-the-art SSBs is reported. The feasibility of ionic liquid (IL)-based interlayers to improve ISE/Li metal wetting and enhance charge transfer at solid electrolyte interfaces with both positive and lithium metal electrodes is presented together with a novel generation of IL-containing quasi-solid-state-electrolytes (QSSEs), offering favourable features. The opportunities and challenges of QSSE for the development of high energy and high safety quasi-solid-state lithium metal batteries (QSSLMBs) are also discussed.
Clinical and pathogenetic aspects of neutrophilic bronchial inflammation in asthma patients with cold-induced airway hyperresponsiveness (literature review)
Authors: Pirogov A. B. , Prikhodko A. G. , Pirogova N. A. , Perelman J. M.
Published: April 2023

The review presents data on the effect of neutrophilic bronchial inflammation on the clinical course, external respiration, and formation of the airway response to cold air in patients with asthma. According to the results of modern studies, activation of the structural and functional state of neutrophils in a mixed inflammatory pattern is associated with an increase in disease severity, more difficult achievement of asthma control, pronounced impairment of bronchial patency due to stimulation of epithelial destruction and remodeling, and development and maintenance of cold-induced airway hyperresponsiveness.

The mechanisms activating the Th1 cytokine profile and oxidative and halogenation stress and determining the activity of neutrophils and persistence of chronic inflammation lead to oxidative damage to lung parenchyma and epithelial dysfunction, which contributes to cold-induced bronchoconstriction. Cytolysis and NETosis, acting as alternative pathways of neutrophil death in the airways of asthma patients, are considered in terms of final stages of induced activity of neutrophil lysosomes in the mixed asthma phenotype.
Prognostic value of the inferior vena cava diameter, lung ultrasound, and the NT-proBNP level in patients with acute decompensated heart failure and obesity
Authors: Kobalava Zh. D. , Cabello Montoya F. E. , Safarova A. F. , Tolkacheva V. V. , Abramov A. A.
Published: April 2023

Aim. To evaluate the clinical and prognostic value of the inferior vena cava (IVC) diameter, the sum of B-lines according to lung ultrasound (LUS), and the NT-proBNP level in patients with acute decompensated heart failure (ADHF) and obesity.

Materials and methods. A single-center, prospective study included 162 patients with ADHF (66% men, age 68 ± 12 years, left ventricular ejection fraction (LVEF) 44 (35; 54)%, median level of NT-proBNP 4,246 (1,741; 6,837) pg / ml). 27.8% of patients were overweight, 55% of patients had obesity. Upon admission, all patients underwent a standard clinical and laboratory examination, including lung ultrasound with the calculation of the sum of B-lines, IVC ultrasound, and determination of the NT-proBNP level.

Results. Obese patients had a smaller sum of B-lines according to lung ultrasound than overweight patients and those with normal weight [33 (21–51); 38 (27–54), and 42 (30–58), respectively; p = 0.002] and a lower level of

NT-proBNP [3,404 (1,630; 5,516); 4,458 (2,697; 5,969); 5,085 (2,871; 7,351) pg / ml, respectively, p = 0.013]. The

IVC diameter did not differ significantly depending on body mass index (BMI): with obesity – 2.3 (1.9–2.8) cm, with overweightness – 2.3 (1.9–2.8) cm, and with normal weight – 2.2 (1.8–2.4) mm, p = 0.324.

According to the multivariate Cox regression analysis, the sum of B-lines > 7 at discharge (hazard ratio (HR) 8.90, 95% confidence interval (CI) 2.03–38.30, p = 0.003) and IVC > 2.4 cm at admission (HR 5.42, 95% CI 1.04–28.13, p = 0.045) were independently associated with a higher risk of 12-month mortality from cardiovascular disease.

Conclusion. Therefore, lung ultrasound with B-line quantification and assessment of the IVC diameter may be useful in obese patients with ADHF to stratify the risk of 12-month mortality from cardiovascular disease.
In situ identification of both IL-4 and IL-10 Cytokine-Receptor Interactions during tissue regeneration
Authors: Nikovics Krisztina , Favier Anne-Laure , Rocher Mathilde , Mayinga Céline , Gomez Johanna , Dufour-Gaume Frédérique , Riccobono Diane
Published: April 2023

Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process. Determining the orchestration of cytokine interactions with their receptors on their cellular targets is essential to fully understand the process of inflammation and tissue regeneration. To this end, we have investigated the interactions of Interleukin-4 cytokine (IL-4)/Interleukin-4 cytokine receptor (IL-4R) and Interleukin-10 cytokine (IL-10)/Interleukin-10 cytokine receptor (IL-10R) using in situ Proximity Ligation Assays in a regenerative model of skin, muscle and lung tissues in the mini-pig. The pattern of protein-protein interactions was distinct for the two cytokines. IL-4 bound predominantly to receptors on macrophages and endothelial cells around the blood vessels while the target cells of IL-10 were mainly receptors on muscle cells. Our results show that in situ studies of cytokine-receptor interactions can provide unravel the fine details of the mechanism of action of cytokines.
The Use of Reticuloruminal Temperature, Reticuloruminal pH, and Cow Activity To Predict Clinical Mastitis in Dairy Cows
Authors: Antanaitis Ramūnas , Anskienė Lina , Palubinskas Giedrius , Rutkauskas Arūnas , Baumgartner Walter
Published: April 2023

We hypothesized that reticuloruminal temperature and pH, as well as cow activity, can be used as biomarkers for the early diagnosis of clinical mastitis in dairy cows. Therefore, we aimed to detect the relationship between reticuloruminal temperature and pH, cow activity, and clinical mastitis in dairy cows.
We randomly selected cows with clinical mastitis and clinical healthy cows (HG) out of 600 milking cows. We recorded the following parameters during the experiment: reticulorumen tem-perature (RR temp.), reticulorumen pH (RR pH), and cow activity. We used smaXtec boluses (smaXtec animal care technology®, Graz, Austria). In this investigation, reticulorumen data ob-tained seven days before diagnosis were compared to HG data from the same time period. CM cows were observed on the same days as the healthy cows.
The healthy group’s RR pH was 7.32% higher than that of cows with CM. Reticulorumen temperature was also 1.25% higher in the CM group than in the control group. The healthy group had a higher average value for walking activity and was 17.37% higher than the CM group. The data of reticulorumen pH changes during 24 h showed that during the day, the pH changed from 5.53 to 5.83 in the CM group. By contrast, pH changed from 6.05 to 6.31 in the control group. The lowest reticulorumen pH in the CM group was detected on the third day before diagnosis. It was 15.76% lower than the highest reticulorumen pH detected on the sixth day before diagnosis. The lowest reticulorumen pH in CM cows was detected at 0 and 1 days before diagnosis. It was 1.45% lower than the highest reticulorumen pH detected on the second day before diagnosis. The lowest walking activity in the CM group was detected 0 days before diagnosis, 50.60% lower than on the fifth day before diagnosis. The lowest walking activity was detected 0 days before diagnosis, 39.57% lower than on the seventh day before diagnosis.
In this study, we found that reticuloruminal temperature, reticuloruminal pH, and cow ac-tivity could be used as biomarkers for the early diagnosis of clinical mastitis in dairy cows.
An Overview of Nano-structural Hard Coating Synthesis, Design, and Applications
Authors: K.G. Sagar , Fernandes Filipe
Published: April 2023

Advanced Nano structural hard coatings are thin materials films that range in thickness from a few nanometers to a few micrometers and are applied to different surfaces to increase their hardness and wear resistance. Physical vapor deposition (PVD) or chemical vapor deposition (CVD) methods are frequently used to deposit these coatings. These coating’s distinctive characteristics result from their microstructure, which is made up of material columns or grains with a diameter of only a few nanometers. Increased hardness, higher wear resistance, and improved tribological properties result from these short dimensions. In applications with significant wear and/or high contact pressures, such as cutting tools, bearings, and engine parts, the usage of sophisticated Nano structural hard coatings is crucial. Advanced Nano structural hard coatings include, 1. Amorphous carbon coatings with high hardness, low friction, and exceptional wear resistance are known as diamond-like carbon (DLC) coatings. DLC coatings are frequently used in a variety of industries, including the automotive, aerospace, and biomedical ones. 2. Coatings made of titanium nitride (TiN): These metallic coatings have high hardness and wear resistance. Cutting tool, machining, and aerospace industries frequently use TiN coatings. 3. Chromium nitride (CrN) coatings: These coatings have great corrosion resistance, good wear resistance, and high hardness. Cutting tools, gears, and bearings are just a few of the objects that use CrN coatings. 4. Tungsten carbide (WC) coatings: These coatings, which have a high degree of hardness and wear resistance, are frequently employed in cutting tools and other applications that require wear resistance. Advanced Nano structural hard coatings provide many advantages over conventional coatings, including better hardness, increased wear resistance, and improved tribological qualities. The automotive, aerospace, and biomedical industries are just a few that could use these coatings. In this paper the author will explain about the design synthesis and applications of advanced Nano structural hard coating in aerospace and automotive applications.
Is Thoracic Kyphosis Relevant to Pain, Autonomic Nervous System Function, Disability, and Cervical Sensorimotor Control in Patients with Chronic Nonspecific Neck Pain?
Authors: Moustafa Ibrahim Moustafa , Shousha Tamer Mohamed , Arumugam Ashokan , Harrison Deed E.
Published: April 2023

There is great interest in thoracic kyphosis as it is thought to be a contributor to neck pain, neck disability, and sensorimotor control measures; though this has not been completely inves-tigated in treatment or case control studies. This case control design investigated participants with non-specific chronic neck pain. Eighty participants with a defined hyper-kyphosis (> 55°) were compared to 80 matched participants with normal thoracic kyphosis (< 55°). Participants were matched for age and neck pain duration. Hyper-kyphosis was further categorized into two distinct types: postural kyphosis (PK) and Scheuermann’s kyphosis (SK). Posture measures included formetric thoracic kyphosis and the craniovertebral angle (CVA) to assess forward head posture. Sensorimotor control was assessed by the following measures: smooth pursuit neck torsion test (SPNT), overall stability index (OSI) and left and right rotation repositioning accuracy. A measure of autonomic nervous system function included the amplitude and latency of skin sympathetic response (SSR). Differences in variable measures were examined using the Student’s t-test to compare the means of continuous variables between the two groups. Pearson correlation was used to evaluate the relationship between participant’s thoracic kyphosis magnitude (in each group separately and as an entire population) and their CVA, SPNT, OSI, head repositioning ac-curacy, and SSR latency and amplitude. Hyper-kyphosis participants had a significantly greater neck disability index compared to the normal kyphosis group (p < 0.001) with the SK group having greatest disability (p < 0.001). Statistically significant differences between the two kyphosis groups and the normal kyphosis group for all the sensorimotor measured variables were identified with the SK group having the most decreased efficiency of the measures in the hyper-kyphosis group, including: SPNT, OSI and left and right rotation repositioning accuracy. Also, there was a signif-icant difference in neurophysiological findings for SSR amplitude (entire sample of kyphosis vs. normal kyphosis, p < 0.001), but there was no significant difference for SSR latency (p = .07). The CVA was significantly greater in the hyper-kyphosis group (p < 0.001). The magnitude of the thoracic kyphosis correlated with worsening CVA (with the SK group having the smallest CVA; p < 0.001) and the magnitude of the decreased efficiency of the sensorimotor control measures and the amplitude and latency of the SSR. The PK group, overall, showed the greatest correlations between thoracic kyphosis and measured variables. Participants with hyper-thoracic kyphosis exhibited abnormal sensorimotor control and autonomic nervous system dysfunction compared to those with normal thoracic kyphosis.
Relationship between Body Mass Index and Diagnosis of Overweight or Obesity in Veterans Administration Population
Authors: Baser Onur , Baser Erdem , Samayoa Gabriela Maria
Published: April 2023

Background: This paper examined the gap between obesity and its diagnosis for cohorts of patients with overweight, obesity, and morbid obesity in the Veterans Administration (VA) population. Using the risk adjustment models, it also identified factors associated with the underdiagnosis of obesity.
Methods: Analysis was performed on a VA data set. We identified diagnosed patients and undiag-nosed patients (identified through BMI but not diagnosed by ICD-10 codes). The groups’ de-mographics were compared using nonparametric chi-square tests. We used logistic regression analysis to predict the likelihood of the omission of diagnosis.
Results: Of the 2,900,067 veterans with excess weight, 46% were overweight, 46% had obesity, and 8% of them had morbid obesity. The overweight patients were the most underdiagnosed (96%), followed by the obese (75%) and morbidly obese cohorts (69%). Older, male, and White patients were more likely to be undiagnosed as overweight and obese; younger males were more likely to be undiagnosed as morbidly obese. (p<.05) Comorbidities significantly contributed to diagnosis.
Conclusion: Underdiagnosis of obesity continues to be a significant problem despite its prevalence. Diagnosing obesity accurately is necessary to provide effective management and treatment.
Understanding the Importance of Eco-Labeling for Organic Foods at UNESCO Biosphere Reserves: A Case Study of the Cocoa Powder at the Dong Nai, Vietnam
Authors: Nguyen An Thinh , Ha Van Dinh , Ngo Huy Kien , Le Ngoc Anh , Khong Phuong Mai , Do Ngoc Tram Thi , Trinh Minh Thuan , Nguyen Tuan Dat , Ngo Tran Quoc Khanh , Vu Linh Chi , Do My Luong Thi , Le Anh Tu , Tran Binh Minh , Nguyen Van Thuong
Published: April 2023

This study examines the Willingness-To-Pay (WTP) of consumers and the determinants of eco-labeling for the organic cocoa powder produced in the Dong Nai UNESCO Biosphere Reserve (DNBR), Southern Vietnam. Eco-labels are designed according to Tiers of eco-labeling for biosphere reserves (BR) introduced by UNESCO include BR Destination (Tier 1), BR Quality Label (Tier 2), and Professional Certification Label (Tier 3). Questionnaires are delivered to 203 customers in the DNBR and nearby places, such as Dong Nai and HCMC. This study employs a hybrid approach using descriptive statistics, ANOVA test, and Partial Least Squares Structural Equation Model (PLS-SEM). The results indicate that gender and educational level have a positive effect on consumers' preferences. Customers are willing to pay more for cocoa powder with an eco-label than one with an organic label. Perceived food safety and product knowledge lower customers’ WTP, whereas agricultural environment and pricing concerns increase it. Tier 2 is suggested for labeling cocoa powder in the DNBR. The DNBR Management Board, together with the federal and provincial governments, should all follow a similar certification process. Increased eco-label awareness is crucial for the future of environmentally responsible shopping and responsible business practices.
Why is the Income Impact of Farmland Transfer Inconsistent Between Transferred-Out and Transferred-in Households?
Authors: Ke Lian , Cheng Shan , Chen Diqiang , Li Ying
Published: April 2023

Based on the 2013–2017 Chinese Family Database and China Household Finance Survey, the study examines the impact of farmland transfer on the income structure of agricultural households. We observe a significant rise in the income of transferred-out households, while that of transferred-in households is unchanged. A further empirical decomposition of income shows a significant increase in both the wage and asset generated incomes of transferred-out households. Although the income generated by transferred-in households through agricultural production and management increases significantly, the decrease in wage income is larger. The study’s empirical designs are robustly tested with propensity score matching and instrumental variables. Moreover, we conduct a comparative analysis of the external constraints faced by the two groups to explore the reasons for the divergence of the income effect. The results show that transferred-in households face highly pronounced external constraints in terms of capital, technology, and farmland size, while transferred-out households face relatively fewer impediments to non-agricultural employment. Our empirical results imply that external constraints can limit the social welfare improvements of agricultural land reform, suggesting that other complementary measures would be required for future policy improvements to work better.
Identification and functional analysis of transcriptome profiles, long non-coding RNAs, single-nucleotide polymorphisms, and alternative splicing from the oocyte to the preimplantation stage of sheep by single-cell RNA sequencing
Authors: Zhang Zi Jing , Shi Qiao ting , Zhu Xiao ting , Jin Lei , Lang Li min , Lyv Shi jie , Xin Xiao ling , Huang Yong zhen , Yu Xiang , Li Zhi ming , Chen Su Juan , Xu Zhao xue , Zhang Wei , Wang Er yao
Published: April 2023

Numerous dynamic and complicated processes characterize development from the oocyte to the embryo. However, given the importance of functional transcriptome profiles, long non-coding RNAs, single-nucleotide polymorphisms, and alternative splicing during embryonic development, the effect that these features have on the blastomeres of 2-, 4-, 8-, 16-cell, and morula stages of development have not been studied. Here, we conducted a scRNA-seq survey of cells from sheep from the oocyte to the blastocyst developmental stages. We then carried out experiments to identify and functionally analyze the transcriptome profiles, long non-coding RNAs, single-nucleotide polymorphisms (SNPs), and alternative splicing (AS). We founded that between the oocyte and zygote groups significantly down-regulated genes and the second-largest change in gene expression occurred between the 8- and 16-cell stages. We used various methods to construct a profile to characterize cellular and molecular features and systematically analyze the related GO and KEGG profile of cells of all stages from the oocyte to the blastocyst. This large-scale, single-cell atlas provides key cellular information and will likely assist clinical studies in improving preimplantation genetic diagnosis.
The Impact of Sociodemographic, Macroeconomic, and Health Status and Resources on Infant Mortality Rates in Oman: Evidence from 1980 to 2022
Authors: Eltayib Rawaa Abubakr Abuelgassim , Al-Azri Mohammed , Chan Moon Fai
Published: April 2023

Background: The infant mortality rate (IMR) is an important reflection of the well-being of infants and the overall health of the population. This study aims to examine the macroeconomic (ME), sociodemographic (SD), and health status and resources (HSR) effects on IMR, as well as how they may interact with each other. Methods: A retrospective time-series study using yearly data for Oman from 1980 to 2022. Partial Least Squares-Structural Equation Modelling (PLS-SEM) was utilized to develop the exploratory model of the determinants of IMR. Results: The model indicates that HSR determinants directly but negatively affect IMR (= -0.617, p<0.001). SD directly and positively affects IMR (= 0.447, p<0.001). ME only indirectly affects IMR (=-0.854, p<0.001). ME determinants also exert some direct influences on both HSR (= 0.722, p<0.001) and SD (= -0.916, p<0.001) determinants. Conclusions: These findings indicate that an integrated policy that addresses socioeconomic and health-related factors and the overall ME environment is necessary for the health and well-being of the children and the population overall in Oman.
Porcine Circovirus Modulates Swine Influenza Virus Replication in Pig Tracheal Epithelial Cells and Porcine Alveolar Macrophages
Authors: Burgher Pulgaron Yaima , Provost Chantale , Pesant Marie-Jeanne , Gagnon Carl A.
Published: April 2023

The pathogenesis of porcine circovirus type 2b (PCV2b) and swine influenza A virus (SwIV) during co-infection in swine respiratory cells is poorly understood. To elucidate the impact of PCV2b/SwIV co-infection, newborn porcine tracheal epithelial cells (NPTr) and immortalized porcine alveolar macrophages (iPAM 3D4/21) were co-infected with PCV2b and SwIV (H1N1 or H3N2 genotype). Viral replication, cell viability and cytokine mRNA expression were determined and compared between single-infected and co-infected cells. Finally, 3’mRNA sequencing was performed to identify the modulation of gene expression and cellular pathways in co-infected cells. It was found that PCV2b significantly decreased and improved SwIV replication, in co-infected NPTr and iPAM 3D4/21 cells respectively, compared to single infected cells. Interestingly, PCV2b/SwIV co-infection synergistically up-regulated IFN expression in NPTr cells whereas in iPAM 3D4/21 cells, PCV2b impaired the SwIV IFN induced response, both correlating with SwIV replication modulation. RNA-sequencing analyses revealed that the modulation of gene expression and enriched cellular pathways during PCV2b/SwIV H1N1 co-infection is regulated in a cell type-dependent-manner. This study revealed different outcomes of PCV2b/SwIV co-infection in porcine epithelial cells and macrophages and provides new insights on porcine viral co-infections pathogenesis.
The Surprising Roles of Turbulence in Tropical Cyclone Physics
Authors: Emanuel Kerry , Velez-Pardo Martin , Cronin Timothy W.
Published: April 2023

Tropical cyclones have long been known to be powered by turbulent enthalpy fluxes from the ocean surface and retarded by turbulent momentum fluxes into the surface. Here were review evidence that the development and structure of these storms are also partially controlled by turbulence in the outflow near the storm top. Finally, we present new research that shows that tropical cyclone-like, low-aspect-ratio vortices are most likely in systems in which the bottom heat flux is controlled by mechanical turbulence and the top boundary is insulating.
Minimally-Invasive Postero-Inferior Sacroiliac Joint Fusion: Surgical Technique and Procedural Details
Authors: Latif Usman , Hubbell Paul J , Tubic Goran , Guerrero Luis A , Skaribas Ioannis M , Block Jon E
Published: April 2023

Abstract: (1) Background: Minimally-invasive sacroiliac joint (SIJ) fusion is the preferred surgical intervention to treat chronically severe pain associated with SIJ degeneration and dysfunction. (2) Methods: This paper details the ten-step surgical procedure associated with the postero-inferior approach using the PsiF™DNA Sacroiliac Joint Fusion System. (3) Results: The posterior surgical approach with an inferior operative trajectory (postero-inferior) utilizes easily identifiable landmarks to provide the safest, most direct access to the articular joint space for transfixing device placement. Implanting the device through the subchondral bone, provides maximum fixation and stabilization of the joint by utilizing an optimal amount of cortical bone-implant interface. Approaching the joint from the inferior trajectory also places the implant perpendicular to the S1 endplate at a “pivot point” near the sacral axis of rotation, which addresses the most significant motion of the joint. (4) Conclusions: Further observational data from real-world clinical use are encouraged to further validate this procedure as the surgical preference for minimally-invasive SIJ fusion.
PCRMLP : A Two-Stage Network for Point Cloud Registration in Urban Scenes
Authors: Liu Jingyang , Xu Yucheng , Zhou Lu , Sun Lei
Published: April 2023

Urban scene point cloud pose significant challenges for registration due to its large data volume, similar scenarios and dynamic objects. In this paper, we propose PCRMLP, a model for urban scene point cloud registration that achieves comparable registration performance to prior learning-based methods. Compared to previous works which focus on extracting features and estimating correspondence, the model estimates the transformation implicitly from concrete instances. An instance-level urban scene representation method is introduced to extract instance descriptors via semantic segmentation and DBSCAN, which enable the model to obtain robust instance features, filter dynamic objects and estimate transformation in a more logical manner. Then a lightweight network consisting of MLPs is employed to obtain transformation in an encoder-decoder manner. We validate the approach on KITTI dataset. Experimental results demonstrate that PCRMLP can obtain a satisfactory coarse transformation from instance descriptors just in 0.0028s. With a subsequent ICP refinement module, the proposed method achieves higher registration accuracy and computational efficiency than prior learning-based works.
A Rare Case of Naviculo-medial Cuneiform Coalition Treated with Naviculo-medial Cuneiform Arthrodesis
Authors: Feeney Kaylem M. , Kearns Stephen R
Published: April 2023

Case:

A 19-year-old woman developed spontaneous onset of right midfoot pain in the absence of trauma. Conservative management including orthotics and steroid injection reduced, but did not resolve, pain. Weight-bearing x-ray and CT confirmed naviculo-medial cuneiform coalition. After failure of conservative treatment, the patient elected to undergo right naviculo-medial cuneiform arthrodesis and returned to normal activity without pain postoperatively and at 4-year follow-up.

Conclusion:

Naviculo-medial cuneiform coalition is a rare source of midfoot pain, but should be considered as a differential diagnosis. This case suggests that naviculo-medial cuneiform arthrodesis can successfully resolve symptoms if conservative measures fail.
(Ciber)Espaço geográfico da política
Authors: Santos Vitor , Lopes Milena , Rizzatti Maurício , Batista Natália
Published: April 2023

Pensar a linguagem memética enquanto ferramenta de Educação Política, no ensino de Geografia, é fundamental, especialmente, em um contexto que urge pela interpretação crítica dos textos multimodais frente a pós-verdade. Pretende-se, revelar o potencial dos (hiper)textos meméticos, que desfrutam de uma aparição não só nas eleições presidenciais norte-americana (2014) e, de modo especial, brasileira (2014 e 2018) para com a promoção da conscientização política acerca de quem são os candidatos, bem como das instituições democráticas envolvidas em um processo eleitoral, indo além da geração de comicidade efêmera das figuras eleitorais. Para tanto, metodologicamente, este artigo propõe-se a fazer uma espécie de classificação dos memes políticos. A partir da discussão sobre a maneira pela qual as categorias dos memes políticos podem ser utilizadas como linguagem para a promoção da Educação Política nas escolas, o que culminou na proposição de uma nova categoria – a dos memes político-educativos. Cabe destacar que a iniciativa de colocar os memes como metodologia para inserir a política em sala de aula extrapola a catarse que eles são capazes de provocar e estimula o pensamento crítico e a reflexão frente a desinformação.
Study on Ontological Knowledge Integration of Micromachining for Collaborative Process
Authors: Liang Jeremy S
Published: April 2023

To achieve the goal of manufacturing automation, the knowledge integration in collaborative process is very crucial, especially, the heterogeneous information distributed among various cooperative suppliers. Therefore, an ontology-based methodology of knowledge integration is proposed to solve the information heterogeneity in this study. By representing a collaborative business activities for cooperative suppliers, a framework of knowledge integration with ontological schema is generated. Aiming for the schema, an approach of ontology integration on the basis of ontological similarity is promoted. There are two portions included in this approach, mapping and combination, which are implemented through the analysis in similarity of universal and regional two ontologies. To integrate the two ontologies, the relations and restrictions among fields are definitely depicted by semantic web rule language. Eventually, the proposed framework is demonstrated by CNC-WEDM process, and the outcomes satisfy the needs of the knowledge integration to assure that validity of the proposed approach is confirmed.
L-shaped association between dietary riboflavin intake and Cognitive impairment in older adults:NHANES 2011-2014
Authors: Zhang kai , Cai Tianyi , Han Yu , Gu Zhaoxuan , Xie Jinyu , Hou Zhengyan , Yu Xiaoqi , Gao Yafang , Gao Min , Liu Tianzhou
Published: April 2023

Background Research investigating the correlation between dietary riboflavin intake and cognitive function in older adults is scarce and constrained. Our objective was to investigate the relationship between riboflavin intake levels and cognitive performance in individuals aged 60 years and above in the United States.Methods We analyzed data from 2,255 adults aged 60 years and older who participated in the 2011–2014 National Health and Nutrition Examination Survey (NHANES). The Consortium to Establish a Registry for Alzheimer's Disease test, Digit Symbol Substitution Test, and Animal Fluency Test were used to evaluate cognitive performance. Dietary intake was assessed using the 24-hour recall method, which reflects recent dietary habits of individuals and groups. Logistic regression was used to examine the association between riboflavin intake and cognitive impairment, and restricted cubic spline analysis was also conducted.Results The study included a total of 2,255 patients, with 47.9% being male. The incidence of low cognitive function was 23.8%. The findings showed that high riboflavin intake was associated with a lower risk of cognitive impairment in adults in the United States. Compared to those with the lowest intake, individuals with the highest riboflavin intake had a 32% reduction in the correlation between AFT, DSST, and Z-test low cognitive function (OR: 0.68, 95% CI: 0.49–0.96, P = 0.028), a 47% reduction in the correlation between DSST low cognitive function (OR: 0.53, 95% CI: 0.37–0.77, P = 0.001), and a 44% reduction in the correlation between Z-test low cognitive function (OR: 0.56, 95% CI: 0.39–0.8, P = 0.002). The study also found an L-shaped association between low cognition and riboflavin intake, with an inflection point at approximately 2.984 mg/d.Conclusions Our cross-sectional study supported the negative associations of dietary riboflavin intake with low cognitive function, also showed a L-shaped dose–response relationship with the point of 2.984mg/day.
Psychosocial Risk Assessment at work – an international validation study of the Questionnaire for Psychosocial Risk Assessment (QPRA)
Authors: Dettmers Jan , Stempel Christiane R. , Burakova Marina , Coquin Pierre-Alexandre , Moriano Juan A.
Published: April 2023

Due to the increasing number of mental and behavioral disorders, most countries of the European Union have adopted laws and regulations regarding the prevention of psychological ill-health at work. These regulations include the requirement to systematically assess psychosocial work risks, which demands valid and reliable assessment tools. This study explored the validity of the Questionnaire for Psychosocial Risk Assessment at work (QPRA, Dettmers & Krause, 2020) in French and Spanish. We applied rigorous forward-backward translation procedures and culture-sensitive adaptions to ensure the content validity of this risk assessment tool in the different language contexts. Based on a final sample of 166 French, 107 Spanish, and 4210 German full-time employees, we compared item and scale statistics and used multigroup confirmatory factor analysis to test the factor structure and measurement invariance across languages. Furthermore, we examined the relationships between the assessed job characteristics (job stressors and resources) and indicators of employee-work related (ill-)health (emotional exhaustion and work engagement). Preliminary results indicated the need for revising single items to enhance linguistic usage. For the revised language versions, simple item and scale statistics as well scale correlations with theoretically related outcomes, such as emotional exhaustion and work engagement, provided evidence that the instrument produced reliable and valid measurement scores across language versions. Confirmatory factor analysis (cfa) could only be tested for the German and French language version, but not for the Spanish version. Multiple group cfa supported the assumption of strong measurement invariance of the French and the original German version. Future studies should increase the Spanish sample to attain the final assessment of its validity.
Sodium butyrate mediates the JNK/FasL/caspase-8 signalling pathway to regulate intestinal apoptosis and modulate intestinal flora to alleviate glycinin-induced intestinal injury in Cyprinus carpio
Authors: Li Deng-Lai , Zhu Rui , Yang Zhi-Yong , Li Liang , Qu Zi-Hui , Quan Ya-Nan , Wei Xiao-Fang , Shang Guo-Jun , Wang Hao-Tong , Wu Li-Fang
Published: April 2023

The alleviating effect of Sodium butyrate (SB) on intestinal injuries incurred by glycinin in feed was investigated in common carp. The control group (without glycinin and SB), the Gly group (with glycinin), and the remaining 4 groups were added SB (0.75, 1.50, 2.25, 3.00 g/kg) respectively based on the Gly group. 6 groups of diets were isonitrogenous and isoenergetic, and fish were fed with these 6 diets for eight weeks. The findings revealed that glycinin caused apoptosis in the intestine, up-regulated JNK, caspase-3, Bax, caspase-9, p38, caspase-8 and FasL gene expression in the MI, DI and hepatopancreas, while down-regulating ERK and Bcl-2 apoptotic genes. However, no eminent effect on the PI. In contrast, SB2 and SB3 groups eminently reversed these adverse effects. Dietary glycinin eminently reduced the expression of ZO-1, Claudin3, Claudin7 and Occludin1 genes in the MI and DI. SB2 and SB3 groups eminently up-regulated the expression of ZO-1, Claudin3, Claudin7 and Occludin1 expression levels, thereby improving the function of the tightly connected barrier in the intestine. Dietary glycinin also eminently increased serum levels of D-lactate, diamine oxidase, serotonin and endothelin, leading to intestinal damage and increased intestinal permeability. SB2 and SB3 groups reduced serum levels of D-lactate, diamine oxidase, serotonin and endothelin, regulating intestinal permeability. Glycinin disrupted the morphological structure of the intestine, while the SB2 and SB3 groups increased the height and width of the folds of the intestinal villi, thus maintaining the morphological integrity of the intestine. Dietary glycinin upset the intestinal microecological balance by increasing Proteobacteria abundance while lowering Clostridium and Bacteroidetes abundance. The SB2 and SB3 groups altered the composition and number of dominant taxa while increasing the abundance of Firmicutes and Acidobacteria. In conclusion, SB could inhibit apoptosis of intestinal cells through the JNK/FasL/caspase-8 signalling pathway and up-regulate the expression of intestinal tight junction (TJ) genes, maintain intestinal physical barrier and regulate intestinal flora, thereby alleviating glycinin-induced intestinal damage.
Bleaching threatens positive carbonate budgets on Bahraini reefs
Authors: AlMealla Reem , Edullantes Brisneve , Hepburn Leanne
Published: April 2023

Bleaching events impact coral reef functionality and carbonate budget dynamics, which is reflected in reduced reef framework accretion, hindering reef ability to keep pace with sea level rise projections. Reefs in the Arabian Gulf exist in harsh environmental conditions with seasonal temperatures ranging between 16–36◦C. Despite the high thermal thresholds (~ 35◦C) of corals in this region, extensive bleaching and high coral mortality has been reported regionally in 2017. We quantify reef carbonate budgets at a near shore and an offshore reef site in Bahrain in May 2017 and 2018 to assess the impacts of the 2017 severe bleaching event on the budgetary state. Results indicate an overall decrease in hard coral cover from 14.2 ± 5.5% to 8.5 ± 1.4% and a decline in the net carbonate budget state from 3.6 ± 2.2 to 0.3 ± 0.3 kg CaCO3 m− 2 y− 1 at the shallow nearshore Fasht Al Adhm reef indicating a shift from a positive budgetary state to nearly a collapse, whilst the deeper offshore Reef Bul Thamah has increased positively from 3.7 ± 1.2 to 4.2 ± 0.6 kg CaCO3 m− 2 y− 1. We attribute the decline in the nearshore reef to the bleaching event which took place between June – September 2017, resulting in high coral mortality rates and subsequent reduced framework carbonate production. Predicted warming trends present a threat to the structural integrity of shallow Bahraini reefs, compromising their ability to keep pace with future SLR projections.
Correlation Between External Exposure and Quantified Activity for Patients Undergoing NeT-177LU Therapy
Authors: Barquero Raquel , Villar Carlos , Hurtado Antonio , Andres Carlos , Ruano Ricardo , Torres Ricardo
Published: April 2023

Background: To assess the absorbed dose in red marrow as a critical organ of treatment, the total uptake of 177Lu activity for patients undergoing neuroendocrine tumor (NET) with LUTATERA_177_Lu_therapy was determined from routine external dose survey measurements and total quantification from SPECT-CT images.
Aims: Study the correlation of body activity obtained with image with the activity obtained by means of an external exposure monitor. Optimize the number of measurements necessary to be able to assess the evolution of body activity of each patient with the least discomfort.
Methods: The data of 4 images per cycle for 4 cycles of 3 patients were analyzed. The temporal evolution of Aima(t) whole body activity was estimated by means of a series of image acquisitions with SPECT-CT on days 1, 2, 5 and 7 of each cycle. The external dose at 1 m from the patient was determined with a radiation survey meter, measuring the ambient dose equivalent H* at the same moments as with the SPECT-CT images to determine the evolution of whole body activity Amon(t) determined with a conversion factor from external exposure to activity obtained before the patient cleared activity, that is, in the first minutes after administration, t~0. The correlation between Aima(t) vs Amon(t) was studied by means of a model that estimates the external exposure produced by an activity point equivalent and the study of the distribution pattern of activity of the organs and tissues with the highest uptake. Red marrow doses produced by body activity are estimated using the OLINDA software.
Results: The value of Amon(t) obtained from the administered activity (t~0) is 53%, 57% and 75% of that obtained by quantifying the activity with imaging Aima(t) for patients 1, 2 and 3, respectively. The distribution of activity in the first moments after administration presents a more superficial uptake pattern than that which occurs in the days following this administration, formed mostly in very internal organs such as the liver, kidneys and spleen. The red marrow doses obtained for the 3 patients are 0.92, 1.29 (patient with only one kidney) and 0.58 Gy, respectively.
Conclusion: The red marrow dose of patients undergoing NET with Lu-177 can be estimated from external measurements with radiation survey meter provided that at least, (to reduce patient discomfort to a minumum), one SPECT-CT image is available, acquired over days 1 to 5 after administration.
Urban people’s preferences for life-sustaining treatment or artificial nutrition and hydration in advance decisions
Authors: Wu Yi-Ling , Lin Tsai-Wen , Yang Chun-Yi , Shen Pei-Han , Liu Ching-Nu , Wang Samuel Shih-Chih , Huang Sheng-Jean
Published: April 2023

Objectives This study investigated the preferences of AD, consistency, and differences in LST and ANH preferences, and factors affecting LST and ANH selection among urban residents.Research Methodology: A retrospective observational design and Convenience sampling were utilized in this study. Data of 2337 individuals with legal ability who were at least 20 years old and attended the ACP consultations from January 5 to January 6, 2020, were retrieved from the electronic records.Setting: Taiwan's Patient Right to Autonomy Act was put into effects in 2019 and allowed the signing of advance decisions (AD) through advance care planning (ACP). Withhold and withdrawal from life-sustaining treatment (LST) or artificial nutrition and hydration (ANH) treatment are now allowed for anyone to be in a condition of irreversible coma, vegetative state, severe dementia, or unbearable pain.Main Outcome Measures: Preferences of life-sustaining treatment and artificial nutrition/hydration, clinical conditions, differences from participants' preferences, and factors associated with preferenceResults High consistency was found in the willingness of refusing LST and ANH which differed significantly between the terminal diseases and extremely severe dementia. Besides, ANH was widely accepted as a time-limited treatment as well as authorizing health care agent to make decisions on behalf of the patients.Conclusion Significant differences were found in gender, age, and consultation intention in not wishing the family to take responsibility in making decisions. Influential factors involved cultural impacts and demographics.
A Systematic Review and Meta-Analyses on Early-Childhood-Caries Global Data
Authors: Maklennan Anastasia , Esteves-Oliveira Marcella , Weirichs Richard Johannes , Campus Guglielmo
Published: April 2023

The present study systematically reviewed and provided a meta-analysis on early childhood caries (ECC) global prevalence and its association with socioeconomic indicators, both geographical and regarding unemployment rate, national income as well as income inequalities. Studies published from 2011 to 2022 from PubMed, Scopus and Embase were retrieved by ad hoc prepared search strings. Cross-sectional and cohort studies reporting the prevalence and experience of early childhood caries in children under 71 months in urban or rural communities were included. Primary outcomes of the included studies were the prevalence and experience of ECC. The meta-analyses were conducted for both overall ECC prevalence and experience stratified by country of publication as well as measures of socioeconomic indicators (geographical area, gross national income (GNI), wealth inequality within a nation index (Gini), unemployment rate) using a random effects model using STATA 17®. One hundred publications reporting ECC data from 49 countries (published from 2011–2022) were included and summarized by meta-analysis. The lowest prevalence was reported in Japan (20.6%) and Greece (19.3%). The global estimated random-effect pooled prevalence of ECC was 59.05%, while the estimated overall pooled caries experience (mean dmft) was 3.41 ± 2.40, ECC prevalence was 22.11%, 14.14%, 15.37%, 20.27% and 28.10% for countries with GNI < 5.000USD, > 5.000 < 10.000USD, > 10.000 < 20.000USD, > 20.000 < 40.000 and > 40.000 respectively. For the four different categories of life expectancy (53–70, > 70–75, > 75–80, > 80), the highest pooled prevalence of ECC was in the age category > 75–80 (39.41%) and for the unemployment rate, it was in the category of medium unemployment rate (60.38%). Within the limitations of this study, results from 49 different countries reported a wide range of ECC prevalence. These reports indicated persisting high worldwide distribution of the disease. Both ECC prevalence and experience were associated with geographical areas and GNI.
A Brazilian nationwide multicenter study on Deficiency of Deaminase-2 (DADA2)
Authors: Melo Adriana , de Carvalho Luciana Martins , Ferriani Virginia Paes Leme , Cavalcanti André , Appenzeller Simone , Oliveira Valéria Rossato , Neto Herbert Chong , Rosário Nelson Augusto , Poswar Fabiano de Oliveira , Guimaraes Matheus Xavier , Kokron Cristina Maria , Maia Rayane Elias , Silva Guilherme Diogo , Keller Gabriel , Ferreira Mauricio Domingues , Vasconcelos Dewton Moraes , Toledo-Barros Myrthes Anna Maragna , Barros Samar Freschi , Sales Nilton , Krieger Marta Helena , Kalil Jorge , Mendonça Leonardo Oliveira
Published: April 2023

Introduction: The deficiency of ADA2 (DADA2) is a rare autoinflammatory disease provoked by mutations in the ADA2 gene inherited in a recessive fashion. Up to this moment there is no consensus for the treatment of DADA2 and anti-TNF is the therapy of choice for chronic management whereas bone marrow transplantation is considered for refractory or severe phenotypes. Data from Brazil is scarce and this multicentric study reports 18 patients with DADA2 from Brazil.
Patients and Methods: This is a multicentric study proposed from the Center for Rare and Immunological Disorders of the Hospital 9 de Julho - DASA, São Paulo - Brazil. Patients of any age with a confirmed diagnosis of DADA2 were eligible for this project and data on clinical, laboratory, genetics and treatment were collected.
Results: 18 patients from 9 centers are reported here. All patients had disease onset at the pediatric age (median of 5 years) and most of them from the state of São Paulo. Vasculopathy with recurrent stroke was the most common phenotype but atypical phenotypes compatible with ALPS-like and Common Variable Immunodeficiency (CIVID) was also found. All patients carried pathogenic mutations in ADA2 gene. Acute management of vasculitis was not satisfactory with steroids in many patients and all those who used anti-TNF had favorable responses.
Conclusion: The low number of patients diagnosed with DADA2 in Brazil reinforces the need for disease awareness for this condition. Moreover, the absence of guidelines for diagnosis and management is also necessary to guide diagnosis and treatment of this disorder.