bluuebunny/crossref_metadata_2025 huggingface dataset:
First specimen-based Indonesian record of a rare scorpionfish, Scorpaenopsis obtusa (Actinopterygii: Perciformes: Scorpaenidae), from Alor Island
Authors: Rusdianto Rusdianto , Wibowo Kunto , Limmon Gino V.
Published: March 2023

A single specimen of the shortsnout scorpionfish, Scorpaenopsis obtusa Randall et Eschmeyer, 2002 (Scorpaenidae), collected from the south coast of Ampera, Alor Barat Laut, Alor Island, Indonesia, at 5 m depth, represents the first voucher specimen-supported record of the species from Indonesian waters (previous records from Nusa Penida and northern Sulawesi having being based on underwater photographs). At 91.1 mm in standard length, the Alor specimen is the largest recorded individual of the species to date.
Dung beetles from two sustainable-use protected forests in the Brazilian Amazon
Authors: Carvalho Edrielly C. , Maldaner Maria , Costa-Silva Vinicius , Sehn Heivanice , Franquini Carol , Campos Vinicius , Seba Vinicius , Maia Laís , Vaz-de-Mello Fernando , França Filipe
Published: March 2023

The Amazon Forest is one of the world's most biodiverse ecosystems and yet its protected areas are understudied concerning insects and other invertebrates. These organisms are essential for tropical forests due to their ecological processes, with some species being very sensitive to habitat disturbances. Dung beetles (Coleoptera, Scarabaeidae, Scarabaeinae) have been used as bioindicators for more than 30 years and were surveyed to assess the insect biodiversity of two sustainable-use forest reserves in the Brazilian Amazon.

We report inventories of dung beetles from two Amazonian forest reserves in Pará State, Brazil: the Tapajós National Forest and the Carajás National Forest. Surveys were carried out with baited-pitfall traps installed in 2010, 2016, 2017 and 2019. We collected a total of 3,772 individuals from 19 genera and 96 species. We highlight the importance of Amazonian protected areas as refugia for insect biodiversity, particularly dung beetles, which contribute to many key ecosystem processes.
Long-Term Safety and Efficacy of Ixekizumab in Patients With Axial Spondyloarthritis: 3-year Data From the COAST Program
Authors: Deodhar Atul , Poddubnyy Denis , Rahman Proton , Ermann Jeorg , Tomita Tetsuya , Bolce Rebeca , Leage Soyi Liu , Kronbergs Andris , Johnson Caroline , Araújo Joana , Leung Ann , van der Heijde Désirée
Published: March 2023

Objective

To report safety and efficacy of ixekizumab (IXE) from the COAST program at 3 years, including 1 year from the originating studies (COAST-V, COAST-W, and COAST-X), and 2 years from COAST-Y.

Methods

In COAST-Y, patients continued with the dose received at the end of the originating study at week 52: 80 mg IXE either every 4 weeks (Q4W) or every 2 weeks (Q2W). Placebo-treated patients from COAST-X received IXE Q4W in COAST-Y. Starting at week 116 (week 64 of COAST-Y), patients receiving IXE Q4W could be escalated to Q2W. Safety for patients receiving ≥ 1 dose of IXE and efficacy for patients receiving ≥ 1 dose of IXE Q4W was assessed. Data are summarized as observed.

Results

For the 932 patients who received ≥ 1 dose of IXE (Q2W or Q4W) through 3 years, treatment-emergent adverse events (TEAEs) occurred at an incidence rate (IR) of 38.0 per 100 patient-years (PYs). The most frequently reported were infections (IR 25.7 per 100 PYs) and injection site reactions (IR 7.4 per 100 PYs); the majority of TEAEs were mild or moderate in severity. In total, 7.1% of TEAEs led to discontinuation (IR 3.1 per 100 PYs). All patient groups receiving IXE Q4W assessed through 3 years saw sustained improvements in Ankylosing Spondylitis Disease Activity Score, clinically important improvement, and other efficacy end points.

Conclusion

The 3-year safety profile of IXE in the COAST program is consistent with the previously established long-term safety profile. IXE Q4W provided sustained improvement of disease activity in patients who received treatment through 3 years. (ClinicalTrials.gov:NCT02696785[COAST-V],NCT02696798[COAST-W],NCT02757352[COAST-X], andNCT03129100[COAST-Y])
La puissance aérospatiale et le conflit en Ukraine : quels premiers enseignements ?
Authors: Resplandy Julien
Published: March 2023

La Russie, malgré sa puissance aérospatiale, n’a pas réussi à obtenir la supériorité aérienne. La Défense sol-air (DSA) de l’Ukraine a été relativement efficace, obligeant Moscou à revoir sa stratégie. Les enseignements tirés sont nombreux dont l’usage massif des drones, justifiant le besoin de nouvelles capacités.
Breathers, resonant multiple waves and complexiton solutions of a (2+1)-dimensional nonlinear evolution equation
Authors: Tao Sixing
Published: March 2023

Based on the Hirota bilinear form of a (2+1)-dimensional equation, breathers and resonant multiple waves as well as complexiton solutions are considered in this paper. First, the breather waves are constructed via employing the extend homoclinic test method. By calculation, two kinds of solutions are obtained. Through analysis, three pairs of breathers consisting of hyperbolic functions and trigonometric functions are derived. Furthermore, a rouge wave solution is deduced by applying the Taylor expansion method to a obtained breather wave. In addition, related figures are plotted to illustrate the dynamical features of these obtained solutions. Then, two types of the resonant multi-soliton solutions are obtained by applying the linear superposition principle to the the Hirota bilinear form. At the same time, 3D profiles and 2D density plots are presented to depict the intersection progression of wave motion. Finally, the complexiton solutions are constructed according to the yielded resonant multi-soliton solutions by further utilizing the linear superposition principle. By considering different domain fields, several types of complexiton solutions including the positive ones are derived. Moreover, related 3D and 2D figures are plotted for the obtained results in order to vividly exhibit their dynamics properties.
Investor sentiment and the interdependence structure of GIIPS stock market returns: A multiscale approach
Authors: Agyei Samuel Kwaku , Bossman Ahmed
Published: March 2023

The GIIPS economies are noted to suffer the most consequences of systemic crises. Regardless of their bad performance in crisis periods, their role(s) in asset allocation and portfolio management cannot go unnoticed. For effective portfolio management across divergent timescales, cross-market interdependencies cannot be side-lined. This study examines the conditional and unconditional co-movements of stock market returns of GIIPS economies incorporating investor fear in their time-frequency connectedness. As a result, the bi-, partial, and multiple wavelet approaches are employed. Our findings explicate that the high interdependencies between the stock market returns of GIIPS across all time scales are partly driven by investor fear, implying that extreme investor sentiment could influence stock market prices in GIIPS. The lagging role of Spanish stock market returns manifests at zero lags at high (lower) and medium frequencies (scales). At lower frequencies (higher scales), particularly quarterly-to-biannual and biannual-to-annual, Spanish and Irish stock markets, respectively, lag all other markets. Although portfolio diversification and safe haven benefits are minimal with GIIPS stocks, their volatilities could be hedged against by investing in the US VIX. Intriguing inferences for international portfolio and risk management are offered by our findings.
Assessment of the breeding system in the Algerian narrow coastal endemism Anacyclus linearilobus (Anthemideae, Asteraceae)
Authors: Sánchez-Albert Adrián , Torices Rubén , Kaid-Harche Meriem , Álvarez Inés
Published: March 2023

The breeding system of Anacyclus linearilobus, an annual and endemic species restricted to dune ecosystems of the Algerian coast were assessed through the effect of self-fertilization and intra- and inter-population artificial crosses on the probability of producing viable seeds in 20 individuals from two populations in a common garden. The breeding system was determined for each individual by the self-incompatibility index (ISI). These results were compared with those published for other species of the genus, A. clavatus, A. homogamos and A. valentinus. Results of experimental crosses showed that there was high variation in the female reproductive success between individuals of A. linearilobus, like that found in its sister species, A. valentinus. Unlike the other species in the genus that are self-incompatible, A. linearilobus showed a mixed mating system, with a majority of self-incompatible individuals, others partially self-incompatible and some self-compatible. We argue that this strategy may be related to reproductive assurance in this endemic, annual species whose effective population size has been reduced probably due to individual mating incompatibilities.
Anti-TPO antibody and thyroid hormone levels in Iranian female breast cancer patients and their association with prognostic factors: a case-control study
Authors: Ghahremanfard Farahnaz , Jandaghi Elahe , Ghobad Rahimi , Mirmohammadkhani Majid , Sarabi Mohamadamir
Published: March 2023

The aim of this study was to assess prevalence of anti–thyroid peroxidase (anti-TPO) antibody and thyroid hormones in Iranian female breast cancer patients, compare them to a control population, and investigate their association with prognostic factors. In this case-control study, breast cancer patients were selected from a surgery clinic in a tertiary hospital and control group participants were enrolled from those who had visited for mammography screening. Participants with any history of thyroid disease, or thyroid related medication were excluded from both groups. Groups were assessed for levels of thyroid stimulating hormone (TSH), T3, T4, and anti-TPO. In addition, the status of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2) was determined for cancer patients. Overall 69 participants (39 cancer patients and 30 controls) were included. Difference in serum anti-TPO levels between the two groups was not statistically significant (p-value: 0.184). While a significant difference was observed for T4 and TSH levels between groups (p-value: 0.034 and <0.001, respectively), T3 levels did not reveal any significant difference (p-value: 0.177). In addition, ER, PR, and HER2 status were not correlated with anti-TPO levels. This results can serve as preliminary evidence that thyroid autoimmunity is not correlated with breast cancer incidence in Iranian female population. However, additional studies with larger sample sizes are required for more conclusive evidence
The effect of isolated probiotics from Indonesian Passiflora edulis sims. on interferon gamma levels in peripheral blood mononuclear cell of adult tuberculosis patients in vitro
Authors: Nurrosyidah Iif H. , Mertaniasih Ni M. , Isnaeni Isnaeni
Published: March 2023

Background: Mycobacterium tuberculosis (M.tb) is unique because the bacteria live intracellularly and hide in macrophages so that they can escape from phagocytosis. This is one of the factors that complicate the treatment of M.tb infections. Interferon-gamma (IFN-γ) is a compound that plays an important role in macrophage activation to control intracellular pathogens. Objective: The purpose of this research is to analyze the concentration of IFN-γ in peripheral blood mononuclear cells of adult Tuberculosis patients (TB) after in vitro administration of multistrain probiotics from indigeneous Indonesian red passion fruit (Passiflora edulis Sims.). Method: The probiotics isolated from red passion fruit were introduced into Peripheral Blood Mononuclear Cell (PBMC) adult TB patients who were undergoing Anti-tuberculosis Drug Therapy (ATD) category one at the Trosobo Primary Health Center (Sidoarjo, East Java, Indonesia), and the patients who were undergoing ATD category one treatment were willing to be involved in this study. Result: The probiotics isolated from fermentation-broth of Indonesian red passion fruit were able to increase IFN-γ levels in PBMC of adult TB patients. Conclusion: The red passion fruit probiotics isolated can increase IFN-γ of adult TB patients increased from 0.82% to 23.17% after in vitro administration.
In vitro study of pinostrobin propionate and pinostrobin butyrate: Cytotoxic activity against breast cancer cell T47D and its selectivity index
Authors: Widiandani Tri , Tandian Tiffany , Zufar Bagus D. , Suryadi Andi , Purwanto Bambang T. , Hardjono Suko , Siswandono Siswandono
Published: March 2023

Backgrounds: Pinostrobin has the potential activity as an anti-cancer. However, its activity is still lower than the anticancer drugs on the market. To increase its activity, pinostrobin derivatives have been synthesized, namely pinostrobin propionate and pinostrobin butyrate, which are predicted to have better activity and lower toxicity than pinostrobin after being tested by in silico approach. So the compound deserves to be tested for its anticancer activity and selectivity on normal cells. Objective: This study aims to determine the anticancer activity of pinostrobin propionate and pinostrobin butyrate against the T47D breast cancer cell line and its selectivity against the Vero cell line. Methods: The cytotoxicity test which is anticancer activity test and its selectivity on normal cell were carried out using the MTT(3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The cells used were breast cancer cell line T47D and normal Vero cells. The test results were analyzed using a microplate reader with a wavelength of 570 nm. Results: From the analysis of anticancer activity on T47D cells, the IC50 values of pinostrobin, pinostrobin propionate, and pinostrobin butyrate were 2.93, 0.57, and 0.40 mM, respectively. While the results of the cytotoxicity test on Vero cells obtained the CC50 value of pinostrobin, pinostrobin propionate, pinostrobin butyrate was 1.27, 0.94, and 0.89 mM, respectively. So the SI value of pinostrobin (SI=0.4) is smaller than its derivatives (SI=1.7 and 2.2). Meanwhile, pinostrobin butyrate is more selective than pinostrobin propionate. Conclusions: It can be concluded that pinostrobin propionate and pinostrobin butyrate compounds have greater activity and selectivity than pinostrobin so these compounds are promising to be further developed as anticancer candidates.
Self-medication profiles in school-age adolescents in Surabaya city, Indonesia
Authors: Mufarrihah Mufarrihah , Yuda Ana , Paramanandana Abhimata , Retnowati Dini , Cahyani Devy M. , Sari Retno , Sugiyartono Sugiyartono , Purwanti Tutiek , Isadiartuti Dewi , Hendradi Esti , Miatmoko Andang
Published: March 2023

Background: It has been reported that children are already practicing self-medication. Indeed, at the children’s age, they are not allowed to self-medicate due to limited knowledge regarding self-medication, leading to inappropriate drug therapy or self-toxicity becoming problems in public health. Objective: This study aimed to determine how school-age adolescents carry out self-medication behavior. Methods: The study was designed as a cross-sectional in which data were collected using questionnaire methods. There were 195 students recruited in this study, consisting of SDN Keputih-245 Elementary School students, SMPN 19 Surabaya Junior High School, and SMAN 11 Surabaya Senior High School. Results: The results showed that most of the students had purchased medicine independently without a doctor’s prescription. The primary source of information regarding self-medication by school students is family. Although most of the respondents stated they always inform their parents or doctors, it has been found that the practice of self-medication by school-age teenagers without informing their parents or doctors exists. Moreover, less than 50% of student respondents believe that self-medication is safe. Conclusion: The role of pharmacists is urgently needed to pro- vide proper education related to drug information and self-medication to increase school-age students’ knowledge.
Interpretation of the Expert Consensus on the Traditional Chinese Medicine Prevention and Treatment of Coronavirus Disease 2019 Omicron Variant Infections
Authors: Fang Bangjiang , Wang Xinhui , Wang Shaobai , Kong Li , Ye Yong , Liu Hua , Qi Wensheng , Liu Wanyan , Li Xucheng , Li Guiwei , Chen Xiaorong , Zhang Dechao , Su Hong , Yang Zhixu , Zhang Jinlu , Zhang Wen , Zhou Shuang , Zhao Ruanjin , Mo Yuxia , Liang Qun , Huang Wei , Zhou Changhong
Published: March 2023

Abstract

The Omicron variant of severe acute respiratory syndrome coronavirus 2 remains a global problem. Current data indicate that the Omicron variant causes mild clinical symptoms and few severe cases and deaths. Traditional Chinese medicine (TCM) has demonstrated definite efficacy and distinct advantages in the prevention and treatment of coronavirus disease 2019 (COVID-19). Thus, by focusing on the pathogenic characteristics of the Omicron variant, the Emergency Professional Committee of the World Federation of Chinese Medicine Societies, Emergency and Critical Care Institute of the Shanghai University of Traditional Chinese Medicine, and American Traditional Chinese Medicine Society have brought together clinical experts on the TCM prevention and control of COVID-19 to formulate an expert consensus on the prevention and treatment of Omicron variant infections based on the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 9). This review provides a comprehensive Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main symptoms of interpretation of this expert consensus, covering topics such as discussing the pathogenic characteristics of the Omicron variant from the TCM perspective of “epidemic disease of pathogenic wind,” prevention plans for vulnerable populations, and stratified treatment plans for infected populations. We hope that this review can serve as a reference for the clinical prevention and treatment of the Omicron variant.
Prognostic Utility of a Modified Pediatric Index of Mortality 3 Score Incorporating Nutritional Status: An Observational Study
Authors: Iqbal Zahid Sayeed , Parameswaran Narayanan
Published: March 2023

Background:

The pediatric index of mortality 3 (PIM 3) score is one of the main scores for predicting mortality risk in pediatric intensive care units (PICUs). However, it does not consider nutritional status in its calculation. The inclusion of the same may improve its performance in developing countries.

Aims:

We aimed to develop a modified PIM 3 score incorporating nutritional status in its calculation. We also aimed to assess the prognostic utility of the modified score and to compare the performance of the modified score with the existing PIM 3 score.

Setting and Design:

The modified score was developed based on retrospective data analysis from a PICU in a tertiary care hospital in South India. Testing the scores was accomplished through a prospective observational study in the same PICU.

Subjects and Methods:

All the parameters required to calculate the PIM 3 score and anthropometric parameters were collected. Then, multivariable logistic regression analysis was performed to obtain coefficients for each variable, and an equation for the modified score was framed. The performance of the modified score was prospectively tested in the PICU and compared with the existing PIM 3 score using standardized mortality ratio (SMR) and area under the receiver operator characteristics (ROC) curve.

Results:

A total of 191 patients were included in the retrospective cohort for developing the modified equation, and the same was tested in 82 patients of the prospective cohort. Out of the 82 patients in the prospective arm, 14 (17%) died in the PICU. Total mortality predicted for the modified and original scores was 15.28 and 9.27, SMR was 0.92 and 1.51 and area under the ROC curve was 0.68 (95% confidence intervals [CI]: 0.48–0.89) and 0.69 (95% CI: 0.49–0.88), respectively.

Conclusions:

While both scores have poor discrimination ability, the modified PIM 3 score has an SMR value closer to one, suggesting better reliability.
Propagation of well-prepared states along Martinet singular geodesics
Authors: de Verdière Yves Colin , Letrouit Cyril
Published: March 2023

We prove that for the Martinet wave equation with “flat” metric, which is a subelliptic wave equation, singularities can propagate at any speed between 0 and 1 along any singular geodesic. This is in strong contrast with the usual propagation of singularities at speed 1 for wave equations with elliptic Laplacian.
Cauchy problem for impulsive fractional differential equations with almost sectorial operators
Authors: Jaiswal Anjali , Tyagi Jagmohan
Published: March 2023

We study a class of non-instantaneous impulsive fractional differential equations in a Banach space. We consider the Cauchy problem with Caputo derivative having variable lower limits and almost sectorial operators. We establish the existence of mild solutions in the space of piecewise continuous functions. We employ the properties of semigroup associated with the almost sectorial operator, theory of measure of non-compactness and fixed point theorems.
Freundlich, Langmuir and Temkin isotherm studies of silicon sorption on soils derived from three parent materials in Edo State, Nigeria
Authors: Orhue E.R. , Emomu A.
Published: March 2023

The study was conducted to assess Freundlich, Langmuir, and Temkin isotherm studies of silicon sorption of soils derived from three parent materials in Edo State, Nigeria. A completely randomized design was used to collect fifteen soil samples from five depths in three replications at three locations namely, NIFOR, Uhomora, and Ososo which are developed on Coastal Plain Sand, Imo Shale, and Basement complex rock parent materials respectively. Some soil physical and chemical properties were determined according to standard procedure, in the Faculty of Agriculture laboratory, University of Benin. Samples were equilibrated in 50 ml distilled water containing various amounts of Si as Calcium-Magnesium silicate (CaMgSiO2) to give 50, 100, 200, 400, and 800 mg Si L-1 for 30 min., allowed to stand overnight, equilibrated again for 30 minutes, filtered and Si read colorimetrically. Data obtained were fitted to Freundlich, Langmuir, and Temkin adsorption models. Results showed that the Temkin model expressed Si sorption capacity better considering the R2 values of 0.733, 0.296, and 0.288 for coastal plain sand, Imo shale, and Basement complex rock soils, respectively. The soils formed on Basement complex rock adsorbed more Si than soils formed on Coastal plain sand and Imo shale parent materials, considering the mean Temkin BT (retention capacity of adsorbed Si) values. The Temkin model could be relied upon as a suitable model to determine Si sorption in soils of the study area.
Soil survey, land evaluation and food security scenario in Nigeria
Authors: Obi J.C. , Ogunkunle A.O.
Published: March 2023

Poverty and malnutrition are tragedies and their absence is the national development rubicon. They are captured in sustainable development goals (SDG) 1, 2 and 3 and remained intractable in most developing countries including Nigeria due to largely uncoordinated planning in majority of the facets of the country. The association of these goals (SDG 1, 2 and 3) with agriculture avails the sector a pivotal role and policy and planning becomes critical. The pivotal and critical role of planning in agriculture will be insignificant in the absence of a national soil classification system with accompanying detailed survey and land evaluation. This study highlighted the consequences of the absence of a pragmatic soil survey and land evaluation report for sustainable soil management and its implications to food security in Nigeria. The burden of poverty directly impacts the human dignity and Nigeria’s quest for economic diversification has become imminently indispensable because dependence on fossil fuel is losing its capacity to support growth and development. The primary focus and best option for diversification is agriculture with soil as the basis. This is not just for sustainable development, but for food production in a drive for food security and probably sovereignty. The first step in this drive is proper understanding of the soil resources of the nation through soil survey and land evaluation at a level of realization for sustainable pragmatic agricultural purposes. These are impossible in the absence of a uniform and nationally acceptable classification system (at least at the series level of United States Department of Agriculture Taxonomy) which possess numerous benefits to the extent that continued delay is very detrimental to the growth and development of any contemporary society. This is prior to the indispensable establishment of localized and indigenous classification system for Nigeria soils.
Occupational hazards associated with frozen fish marketing in Abeokuta metropolis in Ogun State, Nigeria
Authors: Olaoye O.J. , Olaoye O.J. , Ojebiyi W.G. , Akinrinola A.O.
Published: March 2023

This study assessed the occupational hazards and injuries associated with frozen fish marketers in Abeokuta metropolis, Ogun State of Nigeria. A two-stage sampling procedure was adopted in sampling 150 fish marketers from 10 popular markets within the study area. Data were elicited with the aid of an interview schedule and analyzed using descriptive statistics such as frequency distribution, percentage, mean, standard deviation, and Pearson’s Product Moment Correlation (PPMC) analytical tools. Results obtained showed that the mean age of the fish marketers was 37.96±11.04 years, the majority were females (87.9%), married (83.2%), and had a mean household size of 9.00±4.00 persons. Also, 54.4% and 42.3% of the fish marketers had secondary and tertiary education, respectively. In terms of safety measures adopted, all the fish marketers used pain relievers after work, while higher proportions usually use hand gloves (76.5%), wear nose masks (86.6%), wear an apron (80.5%), use plaster in cases of cuts (53.7%) and do regular medical check-up (49.7%). Most (60.4%) of the fish marketers were found to be in good/safe working conditions, while more than half (53.0%) of them were exposed to a high level of hazard. A significant negative relationship existed between working conditions and the level of hazard experienced by the fish marketers (r = –0.721, p ≤ 0.01). It was concluded that occupational hazards are associated with frozen fish marketing. The study recommended that fish marketers should operate from shops to avoid dirty, dusty, and noisy environments to improve their working conditions.
Determinants of visit-to-visit systolic blood pressure variability among Ghanaians with hypertension and diabetes mellitus
Authors: S. Sarfo Fred , K. Ayisi-Boateng Nana , B. Nguah Samuel , Sarfo-Kantanka Osei , Kokuro Collins , Ababio Hanson , Adu-Boakye Yaw , Ovbiagele Bruce
Published: March 2023

Objective: To identify the determinants of systolic blood pressure variability (SBPV) among Ghanaians.Design: We undertook a secondary analysis of data collected in a prospective studySetting: The study involved patients with hypertension and or diabetes receiving care in five hospitals in GhanaMain outcome measures: We assessed determinants of SBPV among 2,785 Ghanaian patients. We calculated the standard deviation (SD) of systolic BP recordings of 3 to 10 visits per patient over 18 months as a measure of SBPV. A multivariate linear regression analysis was fitted to identify factors independently associated with risk visit-to-visit SBP standard deviation.Results: The mean SD of individual patient visit-to-visit SBP overall was 14.8± 6.3 mm Hg. Those with hypertension and diabetes had the highest SD of 15.4 ±6.2 mm Hg followed by 15.2 ±6.5 mm Hg among those with hypertension only and then 12.0 ± 5.2 mm Hg among those with diabetes only, p<0.0001. Factors independently associated with SBPV with adjusted ß coefficients (95% CI) included age: 0.06 (0.03 – 0.08) for each year rise in age, eGFR -0.03 (-0.05 - -0.02) for each ml/min rise, low monthly income of <210 Ghana cedis 1.45 (0.43-2.46), and secondary level of education -1.10 (-1.69, -0.50). Antihypertensive classes were associated with SBPV, the strongest associations being hydralazine 2.35 (0.03 – 4.68) and Methyldopa 3.08 (2.39 – 3.77).Conclusion: Several socio-demographic and clinical factors are associated with SBPV. Future studies should assess the contribution of SBPV to CVD outcomes among indigenous Africans and identify actionable targets.
TIỀM NĂNG ỨC CHẾ KHỐI U CỦA CHIẾT XUẤT ETHANOL ĐÔNG TRÙNG HẠ THẢO (Cordyceps militaris) VÀ NẤM VÂN CHI (Trametes versicolor) ĐỐI VỚI BỆNH UNG THƯ VÚ DO DMBA GÂY RA Ở CHUỘT SWISS ALBINO
Authors: TRẦN THỊ PHƯƠNG NHUNG
Published: March 2023

Đông trùng hạ thảo đã được sử dụng như một phương pháp điều trị bổ trợ cho bệnh ung thư vú. Nấm vân chi cũng được chứng minh là có lợi ích thiết thực cho bệnh nhân ung thư vú. Tuy nhiên, tác dụng hiệp đồng của Đông trùng hạ thảo và nấm Vân chi trong điều trị ung thư vú vẫn chưa được khoa học chứng minh. Trong nghiên cứu này chúng tôi đã xây dựng mô hình đánh giá tiềm năng ức chế khố u trong điều trị ung thư vú nhờ tác động của chiết xuất ethanol thô của đông trùng hạ thảo (Cordyceps militaris) và nấm vân chi (Trametes versicolor) (EtCC) (tỷ lệ 1:1) trên chuột Swiss albino. Sau khi khối u vú (do DMBA gây ra) đạt thể tích khoảng 0,5 cm3, những con chuột được điều trị bằng EtCC trong 12 tuần. Sử dụng EtCC (400 mg/kg thể trọng) điều trị cho chuột ung thư vú đã cho thấy thể tích khối u tuyến vú giảm xuống còn 0,51 cm3 (p<0,05), cùng với việc giảm đáng kể các thông số WBC (4,82 x103tb/mm3), ALT (46,7 U/L), AST (34,8 U/L), .... (p<0,05) so với nhóm bệnh ung thư vú (nhóm DMBA). Trong khi đó, khối lượng cơ thể, khối lượng tương đối của tim, gan, phổi, lá lách, thận đã tăng lên so với nhóm đối chứng âm tính (p<0,05). Phân tích mô học cho thấy việc phối hợp đông trùng hạ thảo và nấm vân chi đã ức chế khối u tuyến vú, giúp hồi phục trở lại cấu trúc mô tuyến vú. Như vậy, EtCC có tiềm năng ức chế khối u bằng cách ngăn chặn sự tiến triển của khối u vú trên mô hình chuột. Như vậy, EtCC có tiềm năng ức chế khối u bằng cách ngăn chặn sự tiến triển của khối u vú trên mô hình chuột. Do đó, EtCC có thể được xem như một loại thảo dược tiềm năng trong điều trị ung thư vú.
PHƯƠNG PHÁP PHÂN TÁCH PVC VÀ PET ỨNG DỤNG TRONG TÁI CHẾ NHỰA BẰNG TUYỂN NỔI BỌT KHÍ SAU KHI HYDRAT HÓA BỀ MẶT BẰNG VẬT LIỆU CaO ĐIỀU CHẾ TỪ VỎ TRỨNG GÀ
Authors: NGUYỄN THỊ THANH TRÚC  , NGUYỄN THỊ LAN BÌNH  , LÊ HÙNG ANH  , LÊ THỊ THANH THẢO  , HỒ THỊ KIM NGÂN
Published: March 2023

Polyvinyl chloride (PVC) là loại nhựa chiếm tỷ trọng lớn trong rác thải nhựa và thường ảnh hưởng nghiêm trọng đến môi trường khi tái chế nhiệt do sự hình thành các hợp chất chứa chloride độc hại. Do vậy, thường PVC được phân tách khỏi hỗn hợp và có phương pháp tái chế riêng phù hợp. Tuy nhiên việc tách PVC thường rất khó khăn nhất là hỗn hợp với polyethylene terephthalate (PET) vì chúng có tỷ trọng tương đương và bề mặt kỵ nước giống nhau. Nghiên cứu này tiến hành tách PVC và PET bằng phương pháp tuyển nổi sau quá trình tiền xử lý bề mặt của hai loại nhựa bằng vật liệu CaO điều chế từ vỏ trứng gà. Quá trình xử lý với CaO làm cho bề mặt nhựa PVC chuyển từ kỵ nước sang ưu nước và chìm dưới đáy cột tuyển nổi, trong khi PET vẫn giữ nguyên tính chất kỵ nước nên nổi trên cột tuyển nổi. Kết quả cho thấy 100 % PVC và PET được tách hoàn toàn tại các điều kiện tối ưu gồm: tỷ lệ (CaO: nhựa) là (1:2), pH = 3 - 4, thể tích MIBC 0,2 ml, trong điều kiện không khuấy và 10 phút tuyển nổi với tốc độ khí 2,5 :L/phút. Đây là phương pháp hứa hẹn để cải thiện chất lượng tái chế nhựa thông qua việc tách PVC khỏi hỗn hợp.
ĐỘC TÍNH TRẦM TÍCH KẾT HỢP KIM LOẠI (Cu2+, Pb2+) LÊN PHÔI, ẤU TRÙNG HÀU CRASSOSTREA GIGAS: TRẦM TÍCH TẠI CỬA SÔNG SOÀI RẠP, SÔNG SÀI GÒN – ĐỒNG NAI
Authors: NGUYỄN VĂN PHƯƠNG  , NGUYỄN XUÂN TÒNG  , MAI HƯƠNG  , NGUYỄN THỊ HUỆ
Published: March 2023

Kim loại nặng trong trầm tích tác động bất lợi cho sinh vật đáy. Những tác động đó hiếm khi có thể được dự đoán từ tổng nồng độ kim loại do ảnh hưởng của các dạng tồn tại trong trầm tích là khác nhau. Để đánh giá bất lợi tiềm ẩn do chất ô nhiễm Cu, Pb trong trầm tích, mô hình thử nghiêm độc tính dung dịch lắng trầm tích bổ sung (Cu2+, Pb2+) lên phôi, ấu trùng hàu Crassostrea gigas đã được thực hiện. Mô hình được thực hiện theo 3 giai đoạn: (i) Điều chế mẫu trầm tích được thêm chuấn (Cu2+, Pb2+); (ii) Điều chế các dung dịch lắng từ các mẫu trầm tích đã thêm chuẩn (Cu2+, Pb2+) và (iii) Thử nghiệm độc tính phôi, ấu trùng Crassostrea gigas bằng dung dịch lắng. Các thông số như tỉ lệ thụ tinh, tỉ lệ bất thường của phôi, ấu trùng và EC50 được xác định. Kết quả cho thấy độc chất khi tiếp xúc với tinh trùng, trứng, cả tinh trùng và trứng cho EC50 là 0,024; 0,063; 0,034mg/L đối với Cu và 4,7; 14,0, 5,5 mg/L đối với Pb; Tỉ lệ ấu trùng không phát triển sau 24 giờ cho EC50 là 0,015 mg/L cho Cu và 2,88 mg/L cho Pb. Kết quả cho thấy độc tính Cu cao hơn Pb và trứng ít nhạy cảm hơn so với tinh trùng. Kết quả nghiên cứu có thể sử dụng để dự báo mức độ nhạy cảm của Cu, Pb trong trầm tích vùng cửa sông Soài Rạp lên phôi, ấu trùng hàu Crassostrea gigas.
Identification of the candidate genes of diagnosing rheumatoid arthritis using the single-cell sequencing technology and T cell subclusters analysis of patients with rheumatoid arthritis
Authors: Liu Yajing , Fan Shaoguang , Meng Shan
Published: March 2023

Objectives: This study aims to analyze the heterogeneity among different cell types in peripheral blood mononuclear cells (PBMC) in rheumatoid arthritis (RA) patients and to analyze T cell subsets to obtain key genes that may lead to RA.

Materials and methods: The sequencing data of 10,483 cells were obtained from the GEO data platform. The data were filtered and normalized initially and, then, principal component analysis (PCA) and t-Distributed Stochastic Neighbor Embedding (TSNE) cluster analysis were performed using the Seurat package in R language to group the cells, thereby obtaining the T cells. The T cells were subjected to subcluster analysis. The differentially expressed genes (DEGs) in T cell subclusters were obtained, and the hub genes were determined by Gene Ontology (GO) functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network construction. Finally, the hub genes were validated using other datasets in the GEO data platform.

Results: The PBMC of RA patients were mainly divided into T cells, natural killer (NK) cells, B cells, and monocyte cells. The number of T cells was 4,483, which were further divided into seven clusters. The pseudotime trajectory analysis showed that the differentiation of T cells developed from cluster 0 and cluster 1 to cluster 5 and cluster 6. Through GO, KEGG and PPI analysis, the hub genes were identified. After validation by external data sets, nine genes were identified as candidate genes highly associated with the occurrence of RA, including CD8A, CCL5, GZMB, NKG7, PRF1, GZMH, CCR7, GZMK, and GZMA.

Conclusion: Based on single-cell sequencing analysis, we identified nine candidate genes for diagnosing RA, and validated their diagnostic value for RA patients. Our findings may provide new sights for the diagnosis and treatment of RA.
MiR-30e-5p deficiency exerts an inhibitory effect on inflammation in rheumatoid arthritis via regulating Atl2 expression
Authors: Liu Shanshan , Wang Kai , Li Ju , Liu Yan , Zhang Zhongyuan , Meng Deqian
Published: March 2023

Objectives: This study aims to investigate the inflammatory effect of the microRNA (miRNA) miR-30e-5p on rheumatoid arthritis (RA) development in RA mice and fibroblast-like synoviocytes (FLS).

Materials and methods: MiR-30e-5p and atlastin GTPase 2 (Atl2) expression in RA tissues and RA-FLS was evaluated using real-time quantitative polymerase chain reaction. The function of miR-30e-5p in inflammation of RA mice and RA-FLS was analyzed by enzyme-linked immunosorbent assay (ELISA) and Western blotting. 5-ethynyl-2ˊ-deoxyuridine (EdU) assay was used to detect RA-FLS proliferation. Luciferase reporter assay was to confirm the interaction between miR-30e-5p and Atl2.

Results: MiR-30e-5p expression was upregulated in the tissues from RA mice. Silencing miR-30e-5p alleviated inflammation in RA mice and RA-FLS. MiR-30e-5p negatively modulated Atl2 expression. Atl2 knockdown exerted a proinflammatory effect on RA-FLS. Atl2 knockdown rescued the inhibitory effect of miR-30e-5p knockdown on proliferation and inflammatory response of RA-FLS.

Conclusion: MiR-30e-5p knockdown inhibited the inflammatory response in RA mice and RA-FLS through Atl2.
Equipo virtual de trabajo, una vía para desarrollar competencias en educación a distancia por covid-19
Authors: Cueva Condeso Lucelia , Esteban-Rivera Edwin Roger , Rojas-Cotrina Amancio Ricardo
Published: March 2023

El confinamiento por COVID-19 obligó la implementación de clases virtuales, en ese contexto se planteó determinar cómo influye el equipo virtual de trabajo en el desarrollo de las competencias en estudiantes del nivel de educación secundaria. Mediante el método experimental, el diseño consistió en dos grupos no equivalente con pre y postprueba, a través del cual se logró establecer que el equipo virtual de trabajo desarrolla significativamente las competencias del área de Ciencias Sociales. Por tanto, en el escenario pedagógico de clases virtuales es necesario formar tutores con el propósito de optimizar el desarrollo de competencias de los estudiantes.
La política exterior de los Estados latinoamericanos: enfoques, metodologías y casos
Authors: Salgado Espinoza Raúl
Published: March 2023

Este libro ingresa en el acervo de las relaciones internacionales por su aporte al análisis de la política exterior de los Estados latinoamericanos. A esa contribución se suma otra de gran valor: ante la escasez de textos en español, con los capítulos aquí reunidos se entrega a la comunidad hispanohablante una lectura para reflexionar sobre esta área temática, para pensar en los desafíos que suponen los diversos casos de estudio. En La política exterior… se ofrecen nuevas miradas acerca de cómo se crea el conocimiento en sinergia con los diseños investigativos. Se trata de una valiosa herramienta teórico-metodológica, cuyos alcances se verán reflejados en la docencia y en las investigaciones venideras en el campo de las relaciones internacionales.
The Performance of the Solar Panel Installation Configuration in the Face of Lighting Changes
Authors: Asnil Asnil , Hazman Hanif
Published: March 2023

Partial shadow is one of the factors that affect the efficiency of solar panels, besides temperature and humidity. Partial shade reduces the performance of the solar panel and gives rise to some local maximums. One effort to reduce the negative effects of this partial shade is to reconfigure the installation of solar panels. This study aims to examine the effect of partial shadows with various solar panel configurations. The 3x3 system was used in this study, with several configurations namely Series Parallel (SP), Total Cross Tied (TCT), Triple Tied (TT), Bridge Link (BL), and Honey Comb (HC). The test results are monitored through a Visual Basic-based interface that displays data in graphical form. The test results show that the configuration that produces the most energy is TCT followed by TT, BL, HC and SP which produces the lowest energy from all tests. 

Bayangan parsial merupakan salah satu faktor yang mempengaruhi efisiensi dari panel surya, disamping suhu dan kelembapan. Bayangan parsial membuat kinerja panel surya tidak maksimal dan menimbulkan beberapa titik maksimum lokal. Salah satu upaya untuk mengurangi efek negatif dari bayangan parsial ini adalah dengan melakukan rekonfigurasi pemasangan panel surya. Penelitian ini bertujuan untuk melihat pengaruh bayangan parsial dengan berbagai konfigurasi pemasangan panel surya. Sistem yang digunakan adalah 3x3 dengan konfigurasi Series Parallel (SP), Total Cross Tied (TCT), Triple Tied (TT), Bridge Link (BL), dan Honey Comb (HC). Hasil pengujian dimonitoring melalui interface berbasis Visual Basic yang menampilkan data dalam bentuk grafik. Hasil pengujian menunjukkan konfigurasi yang menghasilkan energi paling besar adalah TCT kemudian diikuti oleh TT, BL, HC dan SP menghasilkan energi yang paling rendah dari semua pengujian.
Risk Management Analysis in Container Yard Development Projects in Eastern Indonesia
Authors: Muttaqin Prafajar Suksessanno , Novitasari Nia , Setyawan Erlangga Bayu
Published: March 2023

A container yard is a place for storing containers, a place for cleaning, and repairs, as well as a place for carrying out container surveys. Currently planning the construction of a container yard in Eastern Indonesia is being carried out. In its construction, a container yard requires large investment costs due to many factors such as the difficulty and high cost of transporting raw materials, permits that require planning, to the need for proper business processes in order to provide smooth operational activities by minimizing risk. The purpose of this study is to identify the risks and causes of risks involved in the container depot development project in Eastern Indonesia using the quantitative risk assessment (QRA) method, so as to provide the most influential risk management recommendations. The research succeeded in identifying 24 risks and 24 causes of risk. Furthermore, from the calculation results, it was concluded that there were 9 most influential risks. 

Depo kontainer merupakan tempat penyimpanan kontainer, tempat pembersihan, perbaikan, serta tempat untuk pelaksanaan survei kontainer. Saat ini sedang dilakukan perencanaan pembangunan depo kontainer di Indonesia Timur. Dalam pembangunanya, depo kontainer membutuhkan biaya investasi yang besar yang disebabkan banyak faktor seperti sulit dan tingginya biaya transportasi bahan baku, perizinan yang membutuhkan perencanaan, hingga kebutuhan akan adanya proses bisnis yang tepat agar dapat memberikan kelancaran pada aktivitas operasional dengan meminimasi risiko. Tujuan penelitian ini adalah mengindenfitikasi risiko dan penyebab risiko yang terdapat pada proyek pembangunan depo kontainer di Indonesia Timur dengan metode quantitative risk assessment (QRA), sehingga dapat memberikan usulan penanganan risiko yang paling berpengaruh. Penelitian berhasil mengidentifikasi 24 risiko dan 24 penyebab risiko. Lebih lanjut dari hasil perhitungan disimpulkan ada 9 risiko paling berpengaruh.
recepción en los ordenamientos sociales italiano y español de las políticas de igualdad entre mujeres y hombres de la Unión Europea
Authors: López Aniorte Maria del Carmen
Published: March 2023

En la Unión Europea, ningún Estado ha alcanzado la igualdad real y efectiva en materia laboral y prestacional, manteniéndose significativas brechas de género en los cuidados, el empleo, los salarios y las pensiones. En los Estados miembros, permanecen arraigados estereotipos sexistas que dificultan a las mujeres el mantenimiento de carreras de cotización largas, continuadas y a tiempo completo, devalúan su actividad laboral, y las alejan de los ámbitos profesionales mejor remunerados. En este contexto, el presente trabajo de investigación analiza los efectos, en el ordenamiento social español e italiano, de la normativa de la Unión Europea en materia de igualdad de género en el trabajo y en las pensiones. Y, a la vista de lo anterior, se valora la eficacia del derecho social de la Unión Europea en orden a lograr la igualdad real y efectiva entre mujeres y hombres en esos campos; y, en particular, si aquel está propiciando avances significativos en la materia en Italia y en España.
Architectural And Structural System Design of Precast Concrete Structures In Earthquake Zones
Authors: Dağ Ilknur , Kuruşcu Ali Osman , Parsa Ali Rıza
Published: March 2023

Precast concrete systems, which are the result of industrialization in the field of construction, are faced with the prejudice of insufficient earthquake resistance despite their many advantages and their use is limited in Turkey. These systems, which have proven earthquake resistance if they are designed properly, can be used safely in low-rise or multi-storey buildings with different functions in earthquake zones. The aim of this study is to determine the architectural design requirements of earthquake-resistant precast concrete structures and to reveal the structural system design approaches. In accordance with this aim, the earthquake effect on the structures was summarized and architectural design principles that would contribute to the earthquake resistance of precast concrete structures were determined firstly. Then, earthquake-resistant structural system design approaches of frame, panel, and cell construction were evaluated separately.
Examining The Policy Narrative and The Role of the Media in the Policy Response to the Covid-19 Crisis in Indonesia
Authors: Muryanto Febriana , Sukristyanto Agus , Juliswara Vibriza
Published: March 2023

This paper aims to investigate the relationship narratives presented in the media and their role in influencing the policymaking process regarding the COVID-19 response in Indonesia. The study is based on an analysis of online news content and in-depth interviews with political advisers to the president and ministers as well as public health experts who were invited to the core group of policymakers. Analysis of the narrative policy framework reveals the relationship between the government's response and the changing tone of media coverage. The study also finds that the media have become an influential platform influencing policy agenda setting.
The Role Of Motivation In Mediating Culture Work And The Work Concept Of Work From Home (Wfh) On Employee Performance Post Pandemic Covid- 19 At Pt Tasblock Industry Indonesia
Authors: Sustenance Ananda Lubis Fazar , Syaifuddin Syaifuddin
Published: March 2023

Work culture is something, a habit that is carried out in an activity that is impossible to change quickly a set of behaviors, feelings and psychological frameworks that are deeply internalized and shared by members of the organization ”.  Osborn and Plastrik (2002:252 ) A person who feels his life satisfaction is fulfilled, then carrying out his work he enjoys his experiences which are accompanied by the level of joy Alston & Dudley (in Hurlock, 1980), where life satisfaction has brought an employee to work with high awareness and motivation for their duties and responsibilities. This research was conducted to prove the most appropriate model in influencing employee performance through motivation, Work from Home (WFH) Culture work Research approach using Structural Equation Modeling (SEM). of the 117 population of employees and taken 54 using the PT. Indonesian Industrial Tasblock.

. Collecting data using a questionnaire is a way for researchers to obtain research data. Results This study shows that the Work and Work From Home curriculum directly has a significant effect on Employee Performance and the Work and Work From Home curriculum affects Employee Performance. Finally, indirectly, motivation has a significant effect in mediating the Curtur of Work and Work From Home on Employee Performance.