bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Retinal Sensitivity in Complete Retinal-Pigment-Epithelium and Outer Retinal Atrophy (cRORA) Lesions in Intermediate Age-Related Macular Degeneration (iAMD) by High-Resolution Microperimetry
Authors: Saßmannshausen Marlene , Ameln Julius , von der Emde Leon , Holz Frank G. , Ach Thomas , Harmening Wolf M.
Published: December 2024

Objective: Lesions characterized as complete retinal pigment epithelium and outer retinal atrophy (cRORA) are linked to the progression of intermediate age-related macular degeneration (iAMD). However, the extent of functional impairment of such precursor lesions remains uncertain. Methods: In this cross-sectional study, 4 participants (mean age ± standard deviation: 71.5 ± 2.1 years) underwent extensive multimodal imaging and psychophysical testing of cRORA lesions secondary to iAMD. Lesion-specific functional testing was performed using patient individualized testing grids with clinical conventional available (Stimulus size: 0.43°, ~125 µm) and experimental adaptive optics scanning light ophthalmoscope (AOSLO, stimulus size 0.07°, ~20 µm) based microperimetry (MP). One cRORA lesion site and one in-eye control region were tested per patient, respectively. Results: AOSLO imaging revealed an overall decrease in photoreceptor reflectivity, areas of hyporeflectivity over drusen, interspersed with hyperreflective foci, and disrupted photoreceptor mosaic in regions of cRORA. Localized retinal sensitivity assessment with clinical conventional MP yielded an average loss of −14.0 ± 3.3 dB at cRORA lesions compared to the in-eye control regions. In contrast, localized visual impairment assessed by high-resolution AOSLO-MP with smaller test stimuli (20 µm) revealed a sensitivity loss of −15.1 ± 5.1 dB at cRORA lesions (p < 0.01). Notably, also the area surrounding cRORA lesions can be impacted. Conclusions: We demonstrated that cRORA lesions are associated with severe localized functional impairment. cRORA precursor lesions may thus be considered as a surrogate outcome measure in future interventional iAMD trials.
Seasonal Variability of Golden Tides (Pylaiella littoralis, Phaeophyceae) and Nutrient Dynamics in a Potentially Eutrophic Intertidal Estuary
Authors: Haro Sara , Bermejo Ricardo , Healy Mark G. , Knöeller Kay , Fenton Owen , Heesch Svenja , Morrison Liam
Published: December 2024

Understanding macroalgal bloom development is crucial for managing eutrophication and protecting estuarine ecosystems. In this study, brown macroalgal blooms (i.e., golden tides) were identified in a potentially eutrophic temperate estuary (NW Ireland). Pylaiella littoralis (Phaeophyceae, Ectocarpales) was monitored at low tide over seven sampling occasions between June 2016 and August 2017. In situ biomass, tissue nutrients (nitrogen (N) and phosphorus (P)), and isotopic signature (δ15N contents) were measured, and relations with environmental drivers were explored. Difference Vegetation Index (NDVI) values from Sentinel-2 satellite imagery were used to assess the spatiotemporal dynamics of P. littoralis biomass (2016–2022). The results indicated that NDVI attributed to golden tides were lowest in 2022, during summer (coinciding with high temperatures and high rainfall) and at the lower shore on the right margin of an entering river. The highest tissue P content was recorded in April 2017, coinciding with in situ biomass peaks (spring–early summer), suggesting elevated P demand. Tissue N content (>2%) and N:P ratios (10–30) indicated occasional P limitation but no N limitation. δ15N data were very low and it was not possible to identify any primary N source. These findings highlight the importance of nutrient management in mitigating golden tides, addressing eutrophication, and preserving estuarine ecosystems.
Spinopelvic Motion Evaluation in Patients Undergoing Total Hip Arthroplasty and Patient-Specific Target for Acetabular Cup Placement
Authors: Koutalos Antonios A. , Gkekas Nifon K. , Akrivos Vasileios , Stefanou Nikolaos , Karachalios Theofilos
Published: December 2024

Background/Objectives: Instability is a major reason for revision after total hip arthroplasty (THA), and acetabular cup placement in the “traditional” safe zone does not protect against dislocations. Spinopelvic mobility may play a role in impingement and dislocation after THA. Personalized acetabular cup placement that incorporates spinopelvic mobility is currently lacking in the literature. Methods: The spinopelvic motion of 116 patients was evaluated during preoperative planning. All patients underwent radiological assessments with an anteroposterior pelvis radiograph in the standing and supine positions and a lateral view of the lumbar spine and pelvis in the standing and sitting positions. The pelvic incidence, pelvic tilt, sacral slope, standing anterior pelvic plane tilt, sitting anterior pelvic plane tilt, and lumbar lordosis angle were measured, and the degree of pelvic motion from standing to sitting was calculated. The development of the patient-specific target for the acetabular cup was based on the mean mobility of the whole group and the specific posture of each patient. Results: The average pelvic incidence was 51.0 ± 13.1 degrees, the sacral slope was 35.0 ± 10.3 degrees, the pelvic tilt was 16.0 ± 13.3 degrees, the standing anterior pelvic plane tilt was 3.4 ± 12 degrees backward, and the degree of lumbar lordosis was 39.5 ± 11.3 degrees. The mean spinopelvic mobility was 27.3 ± 13.4 degrees. The measurements had good to excellent interobserver and intraobserver reliability. On the basis of these measurements, we developed a novel algorithm for a patient-specific target for acetabular cup placement. Conclusions: the evaluation of spinopelvic mobility has good to excellent interobserver and intraobserver reliability and can be used for personalized acetabular cup placement.
New Concepts in Musculoskeletal Medicine
Authors: Haubruck Patrick
Published: December 2024

The clinical relevance of musculoskeletal disorders (MSDs) continues to rise due to an ageing population and changes in lifestyle, and consequently this wide range of diseases and injuries remains a leading contributor to disability on a global scale [...]
Advancing Park Climate Planning Through Scaled Inquiry on Regional and Park-Based Ecosystem Services and Place Attachment
Authors: Perry Elizabeth E. , Budzyn Erin E.
Published: December 2024

Parks near urban areas provide important opportunities for locals to connect with nature and enjoy outdoor leisure. Climate change planning needs in these parks are pronounced, especially given the large local populations they serve. Ecosystem services, particularly cultural ecosystem services, can frame people’s perceived benefits from these park systems and the larger region. Place attachment on park system and regional scales can differentiate the extent of perceived benefits by the strength of park and regional connection. Together, these can highlight priorities for climate action and communication. The Huron-Clinton Metroparks in densely populated southeast Michigan (US) exemplify an important urban-proximate park system grappling with climate change effects within the parks and across the region. We assisted the Metroparks in creating their Climate Action Plan, including surveying regional residents’ and Metroparks recreationists’ (n = 4069). Here, we examine associations between respondents’ prioritized ecosystem services and levels of place attachment to southeast Michigan and the Metroparks. Results show that on both geographic scales of the park system and region, the three most valued cultural ecosystem services were leisure time spent outdoors, appreciation of beauty, and physical/mental health benefits. However, place attachment level (ambivalent, moderate, or strong) on both scales surfaced ecosystem services prioritization differences and a potentially enhanced role of cultural ecosystem services related to relationships—cultural heritage, social capital, and spirituality—within the Metroparks and with the strong place attached. We discuss these patterns and their connections to the park system and regional climate action planning and communication.
Cultural Landscape and Heritage as an Opportunity for Territorial Resilience—The Case of the Border Between Castile and Leon and Cantabria
Authors: Pérez Cano María Teresa , Maruri Arana Ainhoa
Published: December 2024

The loss of functions in Spanish rural areas has triggered territorial inequalities and injustices in a highly complex geographical environment. After the COVID-19 pandemic and in a context of overpopulation in large cities, the rural area emerged as a space of opportunity for more sustainable territorial rebalancing. Despite the evident tendency towards their population emptying, they are places endowed with their own qualities and specific values, currently in danger, especially in border areas between the regions, which are far from centralised nuclei and generate conflicts due to the transfer of powers to them from the State. Among these values is cultural heritage, the safeguarding and enrichment of which depends on the balance between the landscape and the society that hosts it. This work focuses on access to archaeological sites—an important form of heritage prior to the establishment of actual regional divisions, in the depopulated frontier between Cantabria and Castile and Leon—whose potential is presented by their intrinsic relationship with the territory and their ability to identify historical landscapes, advocating for future sustainability on a territorial scale. With all of the above, a cultural landscape delimitation is proposed between both regions that share common characteristics and problems, promoting synergies and territorial readings by analysing the territorial assets of these interior areas so that their potential is not diminished.
Tribological Characteristics of Biolubricant Obtained by Transesterification of Grape Seed Oil
Authors: Silva Thawan Fonseca , Melo Neta Maria Marliete Fernandes de , Ribeiro Filho Paulo Roberto Campos Flexa , Luna Francisco Murilo Tavares de , Cavalcante Célio Loureiro
Published: December 2024

Research on and the development of bio-based lubricants as alternatives to mineral-based lubricants have been encouraged worldwide owing to environmental concerns and the possible depletion of oil reserves. This study explored the use of grape seed oil (GSO), a byproduct of wine production, as a raw material for biolubricant synthesis. GSO contains a triglyceride molecule rich in unsaturated fatty acids, which is ideal for obtaining biolubricants. This study addresses the technical challenges of converting GSO into a lubricant by synthesizing methyl esters (FAME) via transesterification with 2-ethylhexanol to produce a biolubricant (BL) sample. The obtained products were characterized using Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy to confirm the conversion of the molecules. The density, kinematic viscosity, and viscosity index were determined using the parameters established by ASTM. The tribological characteristics of BL were evaluated using a four-ball tribometer configuration. BL exhibited physicochemical characteristics comparable with those of an ISO VG 10 lubricant, a friction coefficient (FC) 40.82% lower than that of a hydrotreated mineral oil sample, and a smoother wear surface. These results indicate that the polarity of the ester functional group was efficient in producing a protective film on metal surfaces.
Comparative Research in the Field of the Parametric Effect of Lubricant Cavitation Initiation and Development on Friction and Wear in Piston Ring and Cylinder Liner Assemblies
Authors: Dellis Polychronis
Published: December 2024

This research follows closely previous findings in flow characteristics and phenomena that take place in the piston ring and cylinder liner interface during motoring and firing engine operation, and also compares results between different optical engine set-ups. Cavitation visualisation in a simulating lubrication single-ring test rig and oil transport and cavitation visualisation in custom made cylinder assemblies of optical engines are the tools used to quantify the transport process under the piston ring and cylinder liner. Simplification of the interface is an essential technique that enhances the researcher’s confidence in results interpretation. Engine complexity and severe oil starvation are impeding the analysis of the experimental results. Visualisation experiments constitute an effective way to test various lubricant types and assess their overall performance characteristics, including their properties and cavitation behaviour. The repeatability of the visualisation method establishes the parametric study effects and offers valuable experimental results. As a further step towards the lubricant composition effect, a link between the lubricant formulation and the operating conditions could be established as the oil performance is assessed with a view to its transport behaviour. Image processing is used to quantify the impact of cavitation on piston ring lubrication in conjunction with varied operating and lubricant parameters. The characteristics of the lubricant and the working environment have an impact on these types of cavities. Viscosity, cavitation, oil film thickness (OFT), lubricant shear-thinning characteristics and friction are all linked.
Laboratory Investigation on Dynamic Complex Modulus of FRPU Composite
Authors: Górszczyk Jarosław , Malicki Konrad , Kwiecień Arkadiusz
Published: December 2024

Civil engineering structures are subject to both static and dynamic loadings. This applies especially to buildings in seismic areas as well as bridges, viaducts, and road and railway structures loaded with road or rail traffic. One of the solutions used to repair and strengthen such structures in the event of emergency damage are fibre-reinforced polyurethanes (FRPUs). The article proposes a laboratory method for determining the dynamic complex modulus of FRPU composite tape. The theoretical basis for determining the complex modulus for the tested material is presented. Laboratory tests were carried out using the tensile method for four cyclic loading frequencies and a cyclic load ratio equal to 0.5. Under the assumed test conditions, the material showed a viscoelastic performance with a dominant elastic part (storage modulus). For a frequency of 0.1 Hz, the viscous part (loss modulus) was about 8% of the storage modulus value, while for a frequency of 10 Hz, this value was about 5%. For a loading frequency of 0.1 Hz, the elastic part of the complex modulus was about 1160 MPa, while for a frequency of 10 Hz, it was about 1790 MPa. With the increase in loading frequency, the absolute value of the complex modulus increased.
Correction: Khazi et al. Influence of Bath Hydrodynamics on the Micromechanical Properties of Electrodeposited Nickel-Cobalt Alloys. Materials 2021, 14, 3898
Authors: Khazi Isman , Mescheder Ulrich , Wilde Jürgen
Published: December 2024

There was an error in the original publication [...]
DFT Study of the Stability and Electronic Properties of Ni-Doped Defected (6,0) and (8,0) Single-Walled Carbon Nanotubes
Authors: Orazi Valeria , Ambrusi Rubén Eduardo , Morelli Alejandro , Juan Alfredo , Marchetti Jorge Mario
Published: December 2024

The interaction of Ni with (6,0) and (8,0) zigzag carbon nanotube exterior surfaces containing two vacancies was studied using density functional theory (DFT). A two-vacancy defect was analysed in order to anchor Ni, and the pristine nanotube was also considered as a reference for each chirality. The adsorbed Ni stability and the nanotube’s geometry and electronic structure were analysed before and after the adsorption. We compared calculations performed using a general gradient functional with those conducted using two semi-classical dispersion methods to assess the van der Waals forces (PBE-D2 and PBE-D3). In addition, the inclusion of the Hubbard parameter for the correction of Ni d electron self-interaction energy was included, and we evaluated energy and electronic structure changes through atomic-level calculations. Adsorption energy, the density of states, and the charge distribution were obtained to establish the Ni binding on the defective nanotube’s dominating mechanisms. The effect of curvature and applied functional influence was also considered. Furthermore, a bonding analysis was performed to complement our comprehension of the interaction between Ni and the nanotube surfaces. The electronic results show that Ni-doped two-vacancy (6,0) and (8,0) carbon nanotubes can be applied for the development of low-resistance contact materials and spintronic devices, respectively.
Magnetoelastic Effect in Ni-Zn Ferrite Under Torque Operation
Authors: Salach Jacek , Kachniarz Maciej , Jackiewicz Dorota , Bieńkowski Adam
Published: December 2024

The magnetoelastic effect is known as the dependence between the magnetic properties of the material and applied mechanical stress. The stress might not be applied directly but rather generated by the applied torque. This creates the possibility of developing a torque-sensing device based on the magnetoelastic effect. In this paper, the concept of an axially twisted toroidal magnetic core as a torque-sensing element is considered. Most known works in this field consider the utilization of an amorphous ribbon as the core material. However, Ni-Zn ferrites, exhibiting relatively high magnetostriction, also seem to be promising materials for magnetoelastic torque sensors. This paper introduces a theoretical description of the magnetoelastic effect under torque operation on the basis of total free energy analysis. The methodology of torque application to the toroidal core, utilized previously for coiled cores of amorphous ribbons, was successfully adapted for the bulk ferrite core. For the first time, the influence of torque on the magnetic properties of Ni-Zn ferrite was investigated in a wide range of magnetizing fields. The obtained magnetoelastic characteristics allowed the specification of the magnetoelastic torque sensitivity of the material and the determination of the optimal amplitude of the magnetizing field to maximize this parameter. High sensitivity, in comparison with previously studied amorphous alloys, and monotonic magnetoelastic characteristics indicate that the investigated Ni-Zn ferrite can be utilized in magnetoelastic torque sensors. As such, it can be used in torque-sensing applications required in mechanical engineering or civil engineering, like the evaluation of structural elements exposed to torsion.
Large Language Model-Assisted Reinforcement Learning for Hybrid Disassembly Line Problem
Authors: Guo Xiwang , Jiao Chi , Ji Peng , Wang Jiacun , Qin Shujin , Hu Bin , Qi Liang , Lang Xianming
Published: December 2024

Recycling end-of-life products is essential for reducing environmental impact and promoting resource reuse. In the realm of remanufacturing, researchers are increasingly concentrating on the challenge of the disassembly line balancing problem (DLBP), particularly on how to allocate work tasks effectively to enhance productivity. However, many current studies overlook two key issues: (1) how to reasonably arrange the posture of workers during disassembly, and (2) how to reasonably arrange disassembly tasks when the disassembly environment is not a single type of disassembly line but a hybrid disassembly line. To address these issues, we propose a mixed-integrated programming model suitable for linear and U-shaped hybrid disassembly lines, while also considering how to reasonably allocate worker postures to alleviate worker fatigue. Additionally, we introduce large language model-assisted reinforcement learning to solve this model, which employs a Dueling Deep Q-Network (Duel-DQN) to tackle the problem and integrates a large language model (LLM) into the algorithm. The experimental results show that compared to solutions that solely use reinforcement learning, large language model-assisted reinforcement learning reduces the number of iterations required for convergence by approximately 50% while ensuring the quality of the solutions. This provides new insights into the application of LLM in reinforcement learning and DLBP.
Private Data Protection with Machine Unlearning in Contrastive Learning Networks
Authors: Chen Kongyang , Wang Zixin , Mi Bing
Published: December 2024

The security of AI models poses significant challenges, as sensitive user information can potentially be inferred from the models, leading to privacy breaches. To address this, machine unlearning methods aim to remove specific data from a trained model, effectively eliminating the training traces of those data. However, most existing approaches focus primarily on supervised learning scenarios, leaving the unlearning of contrastive learning models underexplored. This paper proposes a novel fine-tuning-based unlearning method tailored for contrastive learning models. The approach introduces a third-party dataset to ensure that the model’s outputs for forgotten data align with those of the third-party dataset, thereby removing identifiable training traces. A comprehensive loss function is designed, encompassing three objectives: preserving model accuracy, constraining gradients to make forgotten and third-party data indistinguishable, and reducing model confidence on the third-party dataset. The experimental results demonstrate the effectiveness of the proposed method. Membership inference attacks conducted before and after unlearning show that the forgotten data’s prediction distribution becomes indistinguishable from that of the third-party data, validating the success of the unlearning process. Moreover, the proposed method achieves this with minimal performance degradation, making it suitable for practical applications in privacy-preserving AI.
Existence of Solutions for Generalized Nonlinear Fourth-Order Differential Equations
Authors: Benhiouna Salah , Bellour Azzeddine , Alhuzally Reemah , Alghamdi Ahmad M.
Published: December 2024

In this article, we studied the existence of solutions for a more general form of nonlinear fourth-order differential equations by using a new generalization of the Arzelá–Ascoli theorem and Schauder fixed theorem under easier and general conditions. Moreover, we provided some sufficient conditions on the nonlinear function that allowed us to deduce the nonexistence results. Finally, we outlined an example to illustrate our main results.
Cooperative Behavior of Prosumers in Integrated Energy Systems
Authors: Aizenberg Natalia , Barakhtenko Evgeny , Mayorov Gleb
Published: December 2024

The technical complexity of organizing energy systems’ operation has recently been compounded by the complexity of reconciling the interests of individual entities involved in interactions. This study proposes a possible solution to the problem of modeling their relationships within a large system. Our solution takes into account multiple levels of interactions, imperfect information, and conflicting interests. We present a mathematical statement of the problem of optimal interactions between the centralized system and prosumers in the integrated energy system (IES) with due consideration of the layered architecture of the IES. The paper also contributes a model for arranging the interactions between centralized and distributed energy sources for cases when IES prosumers form coalitions. The implementation of this model is based on multi-agent techniques and cooperative game theory tools. In order to arrive at a rational arrangement of the interactions of prosumers in the IES, the model implements different approaches to the allocation of the coalition’s total payoff (the Shapley value, Modiclus, PreNucleolus solution concepts). Furthermore, we propose a criterion for deciding on the “best” imputation. We contribute a multi-agent system that implements the proposed model and use a test IES setup to validate the model by simulations. The results of the simulations ensure optimal interactions between the entities involved in the energy supply process within the IES and driven by their own interests. The results also elucidate the conditions that make it feasible for prosumers to form coalitions.
Fabricating and Characterization of MPEA Binder Phase Cemented Carbide and Its Comparison with WC-Co
Authors: Zhang Shuailong , Cheng Huichao , Liu Feng , Li Kun , Qian Cheng , Zhang Ji
Published: December 2024

The development and research of physically superior multi-principal element alloy (MPEA) binders as cemented carbide binders is a hot topic. In this work, we fabricated a new type of MPEA binder-cemented carbide using the powder metallurgy method and investigated the effects of ball milling parameters and sintering temperature on the microstructure and mechanical properties of the cemented carbide. The results are compared with those of cobalt binder samples under the same conditions. The results show that the ball milling parameters for low-speed long ball milling time are superior to those for high-speed low ball milling time. Compared with the pure cobalt binder, MPEA binder-cemented carbide significantly slows down the growth of WC grains, improves the mechanical properties of cemented carbide, and achieves a combination of TRS of 2741.5 MPa and Rockwell hardness of 91.1 HRA. The multi-principal element alloy (MPEA) binder has the potential to become an excellent substitute for Co.
Hot Deformation Behavior of Electron-Beam Cold-Hearth Melted Ti-6Al-4V Alloy
Authors: Jia Weiju , Mao Chengliang , Zhou Wei
Published: December 2024

The deformation behavior and microstructure changes of electron-beam cold-hearth-melted (EBCHM) Ti-6Al-4V alloy were investigated. The stress–strain curves of the alloy were obtained, the constitutive model was established based on the Arrhenius equation, and the hot processing map was drawn. The results showed that the stress of the alloy decreases with increasing temperature and decreasing strain rate. In the β phase field, there are more recrystallized grains when the strain rate is slow, and the recrystallization of the β phase does not have enough time to occur when the strain rate is fast. There are obvious shear bands in the microstructure at the strain rate of 10 s−1. In the α + β field, the morphology and crystallographic orientation of the microstructure changed simultaneously. Globularization is a typical microstructure evolution characteristic. The prismatic slip is easier to activate than basal and pyramidal slips. Moreover, globularization of the lamellar α phase is not synchronously crystallographic and morphological.
Nanocarriers Responsive to Light—A Review
Authors: Almadani Ismat F. , Almadani Mohammad F. , AlSawaftah Nour , Abuwatfa Waad H. , Husseini Ghaleb A.
Published: December 2024

The non-specific and minimally selective nature of traditional drug administration methods, along with various other limitations, makes the use of drug delivery systems more favorable. Light-responsive, or light-triggered, drug delivery systems provide more controlled and less invasive treatment approaches, addressing the shortcomings of traditional methods. In this paper, we reviewed studies utilizing light-triggered nanoparticles (NPs) for treating cancer and various other diseases, focusing on photodynamic therapy (PDT) and photothermal therapy (PTT) in both in vivo and in vitro applications. Most of the reviewed studies employed synergistic approaches that combined PDT or PTT with other therapeutic methods to leverage the strengths of both techniques and enhance treatment efficiency or to overcome the individual limitations of each method, which is discussed extensively in this paper.
Subclinical Mastitis in Small-Holder Dairy Herds of Gansu Province, Northwest China: Prevalence, Bacterial Pathogens, Antimicrobial Susceptibility, and Risk Factor Analysis
Authors: Wang Ling , Haq Shahbaz Ul , Shoaib Muhammad , He Jiongjie , Guo Wenzhu , Wei Xiaojuan , Zheng Xiaohong
Published: December 2024

This cross-sectional study assessed the prevalence, bacterial distribution, antimicrobial susceptibility, and potential risk factors associated with subclinical mastitis (SCM) in small-holder dairy herds in Gansu Province, Northwest China. Forty small-holder cow farms were randomly selected from eight cities/counties in six districts of Gansu Province, and a total of n = 530 lactating cows were included in this study. SCM prevalence was noted at 38.87% and 9.72% at the cow and quarter levels, respectively, based on the California Mastitis Test (CMT). The prevalence of the recovered bacterial species was noted as follows: S. agalactiae (36.02%), S. aureus (19.43%), coagulase-negative staphylococci (CNS) (16.11%), S. dysgalactiae (12.80%), E. coli (9.00%), and S. uberis (6.64%). All isolated bacteria were 100% multi-drug-resistant (MDR) except S. aureus (87.8% MDR). Antimicrobial susceptibility profiles revealed the increased resistance (>85%) of these pathogens to penicillin, streptomycin, trimethoprim–sulfamethoxazole, vancomycin, and erythromycin. However, these pathogens showed increased susceptibility to ampicillin, amoxicillin–sulbactam, ceftazidime, neomycin, kanamycin, spectinomycin, norfloxacin, ciprofloxacin, and doxycycline. The multivariate regression analysis demonstrated that old age, high parity, late lactation, lesions on teats, previous history of clinical mastitis, higher milk yield, and milking training were found to be potential risk factors (p < 0.001) associated with developing SCM in small-holder dairy cows in Gansu Province, China. These findings highlight the need for routine surveillance, antimicrobial stewardship, and effective preventive strategies to mitigate SCM in small-holder dairy production and their possible impacts, i.e., increased antimicrobial resistance and infection, on public health.
Mosla Chinensis Extract Enhances Growth Performance, Antioxidant Capacity, and Intestinal Health in Broilers by Modulating Gut Microbiota
Authors: Wang Wei , Wang Yuyu , Huang Peng , Zhou Junjuan , Tan Guifeng , Zeng Jianguo , Liu Wei
Published: December 2024

This study aimed to evaluate the effects of Mosla chinensis extract (MCE) on broiler intestinal health. A total of 240 1-day-old Arbor Acres (AA) broilers (balanced for sex) were randomly allocated into four treatment groups, each with six replicates of 10 chickens. The study comprised a starter phase (days 1–21) and a grower phase (days 22–42). The control group (C) received a basal diet, while the experimental groups were supplemented with low (S1, 500 mg/kg), medium (S2, 1000 mg/kg), and high doses (S3, 2000 mg/kg) of MCE. The results showed that MCE supplementation significantly improved average daily gain in broilers (p < 0.05) and reduced the feed-to-gain ratio in broilers. Additionally, MCE enhanced the anti-inflammatory and antioxidant capacity of broilers. In the duodenum and cecum, MCE significantly upregulated the expression of tight junction proteins Claudin-1, and Occludin, with the high-dose group showing the strongest effect on intestinal barrier protection (p < 0.05). There was no significant difference in ZO-1 in dudenum (p > 0.05). Microbial analysis indicated that MCE supplementation significantly reduced the Chao and Sobs indices in both the small and large intestines (p < 0.05). At the same time, the Coverage index of the small intestine increased, with the high-dose group demonstrating the most pronounced effect. Beta diversity analysis revealed that MCE had a significant modulatory effect on the microbial composition in the large intestine (p < 0.05), with a comparatively smaller impact on the small intestine. Furthermore, MCE supplementation significantly increased the relative abundance of Ruminococcaceae and Alistipes in the large intestine, along with beneficial genera that promote short-chain fatty acid (SCFA) production, thus optimizing the gut microecological environment. Correlation analysis of SCFAs further confirmed a significant association between the enriched microbiota and the production of acetate, propionate, and butyrate (p < 0.05). In conclusion, dietary supplementation with MCE promotes healthy growth and feed intake in broilers and exhibits anti-inflammatory and antioxidant effects. By optimizing gut microbiota composition, enhancing intestinal barrier function, and promoting SCFA production, MCE effectively maintains gut microecological balance, supporting broiler intestinal health.
A Tachyplesin Antimicrobial Peptide from Theraphosidae Spiders with Potent Antifungal Activity Against Cryptococcus neoformans
Authors: Michira Brenda B. , Wang Yi , Mwangi James , Wang Kexin , Asmamaw Demeke , Tadese Dawit Adisu , Gao Jinai , Khalid Mehwish , Lu Qiu-Min , Lai Ren , Li Juan
Published: December 2024

The venoms of Theraphosidae spiders have evolved into diverse natural pharmacopeias through selective pressures. Cryptococcus neoformans is a global health threat that frequently causes life-threatening meningitis and fungemia, particularly in immunocompromised patients. In this study, we identify a novel anti-C. neoformans peptide, QS18 (QCFKVCFRKRCFTKCSRS), from the venom gland of China’s native spider species Chilobrachys liboensis by utilizing bioinformatic tools. QS18 shares over 50% sequence similarity with tachyplesin peptides, previously identified only in horseshoe crab hemocytes, expanding the known repertoire of the tachyplesin family to terrestrial arachnids. The oxidative folding of QS18 notably enhances its antifungal activity and stability, resulting in a minimum inhibitory concentration of 1.4 µM. The antimicrobial mechanism of QS18 involves cell membrane disruption. QS18 exhibits less than 5% hemolysis in human erythrocytes, indicating microbial selectivity and a favorable safety profile for therapeutic use. Furthermore, mouse model studies highlight QS18’s ability as an antifungal agent with notable anti-inflammatory activity. Our study demonstrates QS18 as both a promising template for spider venom peptide research and a novel candidate for the development of peptide antifungals.
Metaverse-Based Evacuation Training: Design, Implementation, and Experiment Focusing on Earthquake Evacuation
Authors: Mitsuhara Hiroyuki
Published: December 2024

Virtual reality (VR) can realize evacuation training in an immersive, interactive, safe, three-dimensional virtual world. Many VR-based evacuation training systems have been developed; however, they typically notify participants explicitly or implicitly before the evacuation training; thus, participants are mentally ready for successful evacuation. To satisfy a prerequisite where participants do not have mental readiness, this study proposes a prototype of a metaverse-based evacuation training system called “Metavearthquake”. The main characteristic of the proposed prototype system is that evacuation training begins unexpectedly due to a sudden earthquake in the metaverse (virtual world); participants are then required to evacuate to a safe place while making decisions under difficult earthquake-caused situations. The prototype system introduces scenarios and nonplayable characters to express difficult situations that may occur after an earthquake occurrence. To heighten training effects, the prototype system supports reflection (reflection-on-action) by replaying the evacuation of participants. An experiment implied that a sudden earthquake is indispensable for realistic simulated evacuation experiences. In summary, Metavearthquake is a metaverse-based evacuation training system that provides realistic simulated earthquake evacuation experiences in terms of evacuation behaviors, emotions, and training effects.
Electrodeposition of Nanostructured Metals on n-Silicon and Insights into Rhodium Deposition
Authors: Pappaianni Giulio , Montanari Francesco , Bonechi Marco , Zangari Giovanni , Giurlani Walter , Innocenti Massimo
Published: December 2024

In this study, we investigate the electrodeposition of various metals on silicon. Mn, Co, Ni, Ru, Pd, Rh, and Pt were identified as promising candidates for controlled electrodeposition onto silicon. Electrochemical evaluations employing cyclic voltammetry, Scanning Electron Microscopy (SEM) associated with energy-dispersive X-Ray Spectroscopy (SEM-EDS), and X-Ray Photoelectron Spectroscopy (XPS) techniques confirmed the deposition of Pd, Rh, and Pt as nanoparticles. Multi-cycle charge-controlled depositions were subsequently performed to evaluate the possibility of achieving tunable electrodeposition of nanostructured rhodium on n-doped silicon. The procedure increased surface coverage from 9% to 84%, with the average particle size diameter ranging from 57 nm to 168 nm, and with an equivalent thickness of the deposits up to 43.9 nm, varying the number of charge-controlled deposition cycles. The electrodeposition of rhodium on silicon presents numerous opportunities across various scientific and technological domains, driving innovation and enhancing the performance of devices and materials used in catalysis, electronics, solar cells, fuel cells, and sensing.
Formation and Magnetic Properties of Transition Metal Atomic Chains on Monolayer MoS2 Grain Boundaries: A First-Principles Study
Authors: Li Zhiyuan , Yang Shuqing , Wang Yiren
Published: December 2024

Magnetic one-dimensional nanostructures show great potential in spintronics and can be used as basic building blocks for magnetic materials and devices with multiple functions. In this study, transition group atomic chains (V, Cr, Mn, Fe, Co, and Ni) are introduced into nonmagnetic MoS2 with a 4|8ud-type grain boundary. Based on first-principles calculations, the V atomic chains show good thermodynamic stability and can self-assemble along the grain boundary direction. The formation of V, Cr, Mn, and Ni atomic chains can induce magnetism into a 4|8ud-type MoS2 system through typical d-d and p-d interactions. This joint effect of transition metal doping and grain boundaries on the magnetism of monolayer MoS2 is of great significance for exploring the electromagnetic properties of monolayer MoS2 for the development of electronic devices.
Association Between Change in Prognostic Nutritional Index During Neoadjuvant Therapy and Dental Occlusal Support in Patients with Esophageal Cancer Under Neoadjuvant Therapy: A Retrospective Longitudinal Pilot Study
Authors: Yamanaka-Kohno Reiko , Shirakawa Yasuhiro , Inoue-Minakuchi Mami , Yokoi Aya , Noma Kazuhiro , Tanabe Shunsuke , Maeda Naoaki , Fujiwara Toshiyoshi , Morita Manabu , Ekuni Daisuke
Published: December 2024

Background: A high prognostic nutritional index (PNI) is associated with good prognosis in patients with esophageal cancer. However, nutritional status often decreases during neoadjuvant therapy. Functional tooth units (FTUs) provide an index for the status of posterior occlusal support. We have previously reported that low PNI is related to low FTUs. Objectives: The purpose of this study was to retrospectively examine whether the status of occlusal support relates to changes in PNI during neoadjuvant therapy in patients with esophageal cancer. Methods: This study included 34 patients who underwent neoadjuvant therapy before esophagectomy (32 men, 2 women; age, 36–82 years) in 2012 at Okayama University Hospital. Patients were divided into the good occlusal support group (FTUs ≥ 11, n = 18) or poor occlusal support group (FTUs < 11, n = 16), and changes in PNI during neoadjuvant therapy were investigated. Results: PNI decreased significantly after neoadjuvant therapy, particularly in the good occlusal support group, and became more dispersed after neoadjuvant therapy. Decreases in PNI after neoadjuvant therapy showed a significant positive correlation with good occlusal support by multiple regression analysis (p = 0.03). The proportions of patients provided with nutritional intervention (p = 0.02) or early dental intervention (p = 0.04) were lower in the good occlusal support group than in the poor occlusal support group. Conclusions: Even in patients with esophageal cancer with good occlusal support experienced significant declines in PNI during neoadjuvant therapy, potentially due to delayed nutritional and dental interventions. Early multidisciplinary interventions are thus recommended for all patients, regardless of preoperative dental or nutritional status.
Traditional Uses, Bioactive Compounds, and New Findings on Pharmacological, Nutritional, Cosmetic and Biotechnology Utility of Capsella bursa-pastoris
Authors: Łukaszyk Aleksandra , Kwiecień Inga , Szopa Agnieszka
Published: December 2024

Capsella bursa-pastoris (L.) Medik. (shepherd’s purse) is a medicinal plant recently introduced to European Pharmacopoeia. The main active compounds responsible for the activity profile of the raw material are flavonoids, phenolic acids, amino acids, phytosterols, vitamins and bioelements. This species is known for its properties supporting the functioning of the digestive system and antihemorrhagic properties in the ethnomedicine of Far Eastern countries. Modern research confirms these directions of activity. Additionally, the latest studies prove the anti-inflammatory, antioxidant, antibacterial, antifungal, acetylcholinesterase and anticancer properties and supportive action in the treatment of gynecological diseases. Shepherd’s purse herb also has a strong position as an edible plant due to the growing interest in this plant as “healthy food”. The protective, softening, antibacterial and antioxidant properties of sprout and herb extracts are useful in the production of modern cosmetics. Moreover, C. bursa-pastoris is valuable thanks to phytoremediation properties and the numerous practical uses in biotechnology for the creation of new resistant varieties of crop plants from the Brassicaceae family.
Mapping Consumer Preference for Vegan and Omnivorous Diets for the Sensory Attributes of Flour Products with Iodine-Fortified Plant-Based Ingredients
Authors: Szymandera-Buszka Krystyna , Jankowska Agata , Jędrusek-Golińska Anna
Published: December 2024

Objectives: Flour products with iodine-fortified dried vegetables can be a good source of iodine. However, in addition to iodine stability, the sensory quality of these products is also important. Therefore, this study aimed to assess the effect of adding iodine-fortified dried vegetables to flour products (gnocchi and ciabatta) on their sensory quality and map consumers (vegan/omnivore diets) as potential consumers of fortified flour products with iodine-fortified dried vegetables. Methods: A quantitative analysis of the sensory desirability and profiling were used to achieve the work objective. Results: It was confirmed that there was no relationship between the form of iodine (without iodine/KIO3/KI) and the intensity of all definite descriptors of colour, aroma, and taste. We also confirmed the relationship between the vegetable type and the descriptors’ intensity. It was confirmed that the positive attribute with the highest impact was the pumpkin taste, and the attribute with the most negative impact was the cauliflower aroma. This was true for consumers on vegan and omnivore diets, and they confirmed the most positive attitude toward the taste of pumpkin. Conclusions: Introducing dried iodine-fortified vegetables (gnocchi dumplings 24%; ciabatta rolls 5%) allows for the high sensory desirability of designed products. Introduced iodine (gnocchi dumplings 30 mg I/100 g; ciabatta rolls 9–11 mg I/100 g) does not change products’ sensory profiles.
Use of Hormone Blockers in Transgender Teenagers: A Scoping Review
Authors: Herrera Jerez M. J. , Castro-Peraza M. E. , Delgado Morales N. M. , Arias Rodriguez A.
Published: December 2024

Hormone blockers are defined as substances that suppress the release of sex hormones, thus inhibiting the development of secondary sexual characteristics in teenagers. There is currently an increase in young people seeking healthcare services due to a mismatch between their birth-assigned gender and their perceived or self-identified gender. In early childhood, individuals are not usually affected by their physical appearance. Dysphoria may arise during the initial stages of adolescence and if the self-perceived gender does not align with the external appearance. This may have a negative impact on adolescents’ mental health. Could the use of hormone blockers have a positive effect on mental health? The primary objective of this review is to assess whether the use of hormone blockers can have positive effects on the mental health of transgender youth. The review also seeks to evaluate the usage of hormone blockers and the diagnosis of gender dysphoria. A literature search of scientific evidence was conducted across various databases—PUBMED, CUIDEN, ELSEVIER, COCHRANE, DIMENSIONS, SCIELO, PSYCINFO, and CINAHL—alongside a review of the latest publications in high-impact scientific journals and the gray literature. The following terms were used: , , , , , , and . A time period was specified, covering the last ten years (2014–2024). The initial search identified a total of 290 references, which were subsequently narrowed down to 5 studies, with 1 additional study retrieved through other methods. The literature findings are clear. They show that the use of hormone blockers in transgender adolescents can be beneficial, as a reduction in mental health issues was observed during and after their use. Mental healthcare in transgender teenagers is of crucial importance to their physical, psychological, social, and academic spheres. It is also very important for their families. Nurses must be aware of this knowledge to improve the care provided to these individuals and their families during the difficult time surrounding decisions about the use of hormone blockers.
Immunodeficiency-Related Vaccine-Derived Poliovirus (iVDPV) Infections: A Review of Epidemiology and Progress in Detection and Management
Authors: Estivariz Concepcion F. , Krow-Lucal Elisabeth R. , Mach Ondrej
Published: December 2024

Individuals with certain primary immunodeficiency disorders (PID) may be unable to clear poliovirus infection after exposure to oral poliovirus vaccine (OPV). Over time, vaccine-related strains can revert to immunodeficiency-associated vaccine-derived poliovirus (iVDPVs) that can cause paralysis in the patient and potentially spread in communities with low immunity. We reviewed the efforts for detection and management of PID patients with iVDPV infections and the epidemiology through an analysis of 184 cases reported to the World Health Organization (WHO) during 1962–2024 and a review of polio program and literature reports. Most iVDPV patients (79%) reported in the WHO Registry were residents in middle-income countries and almost half (48%) in the Eastern Mediterranean Region. Type 2 iVDPV was most frequently isolated (53%), but a sharp decline was observed after the switch to bivalent OPV in 2016, with only six cases reported during 2017–2024 compared to 63 during 2009–2016. Patients with common variable immunodeficiency have longer excretion of iVDPV than with other PID types. Implementation of sensitive sentinel surveillance to detect cases of iVDPV infection in high-risk countries and offer antiviral treatment to patients is challenged by competition with other health priorities and regulatory hurdles to the compassionate use of investigational antiviral drugs.