bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases
Authors: In Gino K. , Ribeiro Jennifer R. , Yin Jun , Xiu Joanne , Bustos Matias A. , Ito Fumito , Chow Frances , Zada Gabriel , Hwang Lindsay , Salama April K. S. , Park Soo J. , Moser Justin C. , Darabi Sourat , Domingo-Musibay Evidio , Ascierto Maria L. , Margolin Kim , Lutzky Jose , Gibney Geoffrey T. , Atkins Michael B. , Izar Benjamin , Hoon Dave S. B. , VanderWalde Ari M.
Published: November 2023

Melanoma brain metastases (MBM) are clinically challenging to treat and exhibit variable responses to immune checkpoint therapies. Prior research suggests that MBM exhibit poor tumor immune responses and are enriched in oxidative phosphorylation. Here, we report results from a multi-omic analysis of a large, real-world melanoma cohort. MBM exhibited lower interferon-gamma (IFNγ) scores and T cell-inflamed scores compared to primary cutaneous melanoma (PCM) or extracranial metastases (ECM), which was independent of tumor mutational burden. Among MBM, there were fewer computationally inferred immune cell infiltrates, which correlated with lower TNF and IL12B mRNA levels. Ingenuity pathway analysis (IPA) revealed suppression of inflammatory responses and dendritic cell maturation pathways. MBM also demonstrated a higher frequency of pathogenic PTEN mutations and angiogenic signaling. Oxidative phosphorylation (OXPHOS) was enriched in MBM and negatively correlated with NK cell and B cell-associated transcriptomic signatures. Modulating metabolic or angiogenic pathways in MBM may improve responses to immunotherapy in this difficult-to-treat patient subset.
Fully 3D printed flexible, conformal and multi-directional tactile sensor with integrated biomimetic and auxetic structure
Authors: Wei Yuyang , Li Bingqian , Domingos Marco , Qian Zhihui , Zhu Yiming , Yan Lingyun , Ren Lei , Wei Guowu
Published: November 2023

Tactile sensors play a crucial role in the development of biologically inspired robotic prostheses, particularly in providing tactile feedback. However, existing sensing technology still falls short in terms of sensitivity under high pressure and adaptability to uneven working surfaces. Furthermore, the fabrication of tactile sensors often requires complex and expensive manufacturing processes, limiting their widespread application. Here we develop a conformal tactile sensor with improved sensing performance fabricated using an in-house 3D printing system. Our sensor detects shear stimuli through the integration of an auxetic structure and interlocking features. The design enables an extended sensing range (from 0.1 to 0.26 MPa) and provides sensitivity in both normal and shear directions, with values of 0.63 KPa−1and 0.92 N−1, respectively. Additionally, the sensor is capable of detecting temperature variations within the range of 40−90 °C. To showcase the feasibility of our approach, we have printed the tactile sensor directly onto the fingertip of an anthropomorphic robotic hand, the proximal femur head, and lumbar vertebra. The results demonstrate the potential for achieving sensorimotor control and temperature sensing in artificial upper limbs, and allowing the monitoring of bone-on-bone load.
Evolutionary trajectory of SARS-CoV-2 genome shifts during widespread vaccination and emergence of Omicron variant
Authors: Gayvert Kaitlyn , McKay Sheldon , Lim Wei Keat , Baum Alina , Kyratsous Christos , Copin Richard , Atwal Gurinder S.
Published: November 2023

Understanding the adaptation of SARS-CoV-2 is critical for the development of effective treatments against this exceptionally successful human pathogen. To predict the emergence of new variants that may escape host immunity or increase virulence, it is important to characterize the biological forces driving its evolution. We conducted a comprehensive population genetic study of over thirteen million SARS-CoV-2 genome sequences, collected over a timeframe of ~3 years, to investigate these forces. Our analysis revealed that during the first year of the pandemic (2020 to 2021), the SARS-CoV-2 genome was subject to strong conservation, with only 3.6% of sites under diversifying pressure in the receptor binding domain (RBD) of the Spike protein. However, we observed a sharp increase in the diversification of the RBD during 2021 (8.1% of sites under diversifying pressure up to 2022), indicating selective pressures that promote the accumulation of mutations. This period coincided with broad viral infection and adoption of vaccination worldwide, and we observed the acquisition of mutations that later defined the Omicron lineages in independent SARS-CoV-2 strains, suggesting that diversifying selection at these sites could have led to their fixation in Omicron lineages by convergent evolution. Since the emergence of Omicron, we observed a further decrease in the conservation of structural genes, including M, N, and the spike proteins (13.1% of RBD sites under diversifying pressure up to 2023), and identified new sites defining future potential emerging strains. Our results exhibit that ongoing rapid antigenic evolution continues to produce new high-frequency functional variants. Sites under selection are critical for virus fitness, and currently known T cell epitope sequences are highly conserved. Altogether, our study provides a comprehensive dynamic map of sites under selection and conservation across the entirety of the SARS-CoV-2 genome.
Facile preparation of a Ni–imidazole compound with high activity for ethylene dimerization
Authors: Liu Zhaohui , Li Guanxing , Alalouni Mohammed R. , Chen Ziyin , Dong Xinglong , Wang Jianjian , Chen Cailing
Published: November 2023

A Ni-imidazole compound was synthesized by a simple one-step co-precipitation method, which exhibited superb catalytic activity for ethylene dimerization reactions.
Water activating fresh NiMo foam for enhanced urea electrolysis
Authors: Wang Haoxuan , Xiong Kang , Gao Lihua , Xue Min , Pan Zhongqin , Huo Xiao-Lei , Zhou Qingwen
Published: November 2023

A simple water-activation strategy was adopted to rapidly synthesize an efficient and stable electrode featuring in situ autologous catalyst–substrate characteristics.
The high resolution absorption spectrum of methane in the 10 800–14 000 cm−1 region: literature review, new results and perspectives
Authors: Campargue A. , Karlovets E. V. , Vasilchenko S. S. , Turbet M.
Published: November 2023

The high resolution experimental spectroscopy of methane above 11 000 cm−1 is reviewed and completed by new results. Comparison with advanced theoretical line lists paves the way for future investigations.
Removal of nitrate by FeSiBC metallic glasses: high efficiency and superior reusability
Authors: Song Jia-Ben , Zhang Yun-Hao , Li Yu-Feng , Zhang Jia-Cheng , Liang Xu , Sha Zhen-Dong
Published: November 2023

Metallic glass can be recognized as a sustainable catalyst for efficient nitrate removal, one of the world's most widespread water pollutants.
Unlocking the predictive power of quantum-inspired representations for intermolecular properties in machine learning
Authors: Santiago Raul , Vela Sergi , Deumal Mercè , Ribas-Arino Jordi
Published: November 2023

New MODA descriptor, a quantum-inspired representation enhancing ML predictions of molecular properties. By using a wave-function guess, MODA captures electronic structure intricacies to excel in intermolecular property predictions.
Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand
Authors: Panda Suvam Kumar , Rai Ankit , Singh Akhilesh Kumar
Published: November 2023

The article highlights a paraCEST study on Co(II) and Ni(II) complexes of a pyridine-tetraacetamide-based ligand. All the required solid and solution state studies of the ligand and complexes have been performed and meticulously discussed.
In situ green synthesis of copper(ii) oxide (CuO) and maleic anhydride grafted polypropylene (PP-MAH) for highly efficient nanocatalysis in tannery wastewater treatment
Authors: Manavi Farnam , Allahgoli Ghasri Mohammad Reza , Ahmadi Shervin , Habibi Sima
Published: November 2023

Green synthesis of CuO/PP-MAH for green catalysis of tannery wastewater treatment.
Fermented cereal-origin gerobiotic cocktails promote healthy longevity in Caenorhabditis elegans
Authors: Govindhan Thiruppathi , Amirthalingam Mohankumar , Duraisamy Kalaiselvi , Cho Jeong Hoon , Tawata Shinkichi , Palanisamy Sundararaj
Published: November 2023

Gerobiotic synergism reveals the secrets to healthy longevity in Caenorhabditis elegans.
Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice
Authors: Han Shuai , Wu Xiuxiu , Zhu Lingfeng , Lu Han , Ling Xuke , Luo Yi , Hu Zuomin , Zhou Yaping , Tang Yiping , Luo Feijun
Published: November 2023

GBR could alleviate hyperlipidemia and its mechanism in the HFD-fed mice.
Research progress on ginger polysaccharides: extraction, purification and structure–bioactivity relationship
Authors: Wu Yuan , Li Bing-Hang , Chen Miao-Miao , Liu Bing , Jiang Liang-Liang
Published: November 2023

Ginger is a widespread source of herbal medicine and traditional spices.
Astaxanthin alleviates fine particulate matter (PM2.5)-induced lung injury in rats by suppressing ferroptosis and apoptosis
Authors: Yin Bowen , Ren Jingyi , Cui Qiqi , Liu Xuanyi , Wang Ziyi , Pei Huanting , Zuo Jinshi , Zhang Yadong , Wen Rui , Sun Xiaoya , Zhang Weican , Ma Yuxia
Published: November 2023

Astaxanthin can attenuate PM2.5-induced lung injury (oxidative stress, inflammation, and histopathological injuries) in rats by inhibiting ferroptosis and apoptosis.
Tuning the photophysical and photo acidic properties of N-methyl-6-oxyquinolonium-based ionic liquid dyes: the role of solvent and substitution effects investigated by a TD-D3-DFT approach
Authors: Hosseini Somayeh , Roohi Hossein
Published: November 2023

In this work, the photophysical and photo acidic properties of N-methyl-6-oxyquinolonium based [6MQc][Y1–6] (Y1–6 = CH3CO2−, CF3CO2−, NTf2−, CF3SO3−, BF4−, and PF6−) ILs were investigated at the TD-PBE0-D3/6-311++G(d,p) level of theory.
One-pot synthesis of Ag–In–Ga–S nanocrystals embedded in a Ga2O3 matrix and enhancement of band-edge emission by Na+ doping
Authors: Tozawa Makoto , Miyamae Chie , Akiyoshi Kazutaka , Kameyama Tatsuya , Yamamoto Takahisa , Motomura Genichi , Fujisaki Yoshihide , Uematsu Taro , Kuwabata Susumu , Torimoto Tsukasa
Published: November 2023

Ag–In–Ga–S nanocrystals embedded in a Ga2O3 matrix produced a narrow band-edge photoluminescence, the intensity being significantly enlarged by Na+ doping, and they effectively served as an emitting layer in green quantum dot-light-emitting diodes.
Insight into the effect of side chains on thermal transport of organic semiconductors
Authors: Yang Chao , Wang Weitao , Peng Boyu , Ji Wanxiang , Wang Xinyu
Published: November 2023

Side chain engineering is employed to tune the intrinsic thermal transport properties of organic semiconductors, and the phonon transport mechanisms of organic semiconductors with phenyl and alkyl side chains are uncovered.
Exceptional green hydrogen production performance of a ruthenium-modulated nickel selenide
Authors: Li Rong , Chen Lanli , Zhang Huaming , Humayun Muhammad , Duan Junhong , Xu Xuefei , Fu Yanjun , Bououdina Mohamed , Wang Chundong
Published: November 2023

Developing low-cost, high-efficiency and stable electrocatalysts for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) is crucial but highly challenging.
Metal-free synthesis of 1,3-dichloro-1,5-diarylpentan-5-ones via cascade oxidative radical addition of styrenes with CHCl3
Authors: Liu Min , Liu Bifu , Wang Qian , Feng Kejun , Li Yuanhua , Liu Lixin , Tong Jiaen
Published: November 2023

A novel and efficient metal-free cascade oxidative radical addition of alkenes is developed for the construction of 1,3-dichloro-1,5-diarylpentan-5-ones.
Construction of diverse spirooxindoles via a domino reaction of arylamines, but-2-ynedioates and 3-hydroxy-3-(indol-3-yl)indolin-2-ones
Authors: Zhu Ling-Yun , Sun Jing , Liu Dan , Yan Chao-Guo
Published: November 2023

An iodine-promoted domino reaction of arylamines/benzylamines, dialkyl but-2-ynedioates and 3-hydroxy-3-(indol-3-yl)indolin-2-ones afforded different spirooxindole derivatives depending on the electronic effect and the position of the substituents.
Synthesis of arene-functionalized fused heterocyclic scaffolds via a regioselective cascade 1,4-conjugate addition/5-exo-dig annulation strategy
Authors: He Xinwei , Wang Demao , Liu Yanan , Wu Mengdi , Kong Yangzilin , Tang Qiang , Wang Yiping , Fan Chenli , Shang Yongjia
Published: November 2023

We have developed an efficient method for the synthesis of highly sterically congested 3-phenolic furo[3,2-c]pyran-4-ones and furo[3,2-c]pyridin-4(5H)-ones by the formation of a furan ring from readily available starting materials in a single step.
Anti-inflammatory unimolecular micelles of redox-responsive hyperbranched polycurcumin amphiphiles with enhanced anti-inflammatory efficacy in vitro and in vivo
Authors: Huang Da , Tang Qiang , Zou Minglang , Wang Yongming , Luo Fang , Mu Jinyi , Wu Yuanzi , Weng Zuquan , Lin Zhenyu
Published: November 2023

The unimolecular micelles of redox-responsive hyperbranched polycurcumin amphiphiles exhibited excellent stability and enhanced the anti-inflammatory activity of curcumin in macrophages and zebrafishes.
Electrocatalytic activity and surface oxide reconstruction of bimetallic iron–cobalt nanocarbide electrocatalysts for the oxygen evolution reaction
Authors: Ritz Amanda J. , Bertini Isabella A. , Nguyen Edward T. , Strouse Geoffrey F. , Lazenby Robert A.
Published: November 2023

Fe-content in FeCo nanocarbides tunes electrocatalytic activity towards the oxygen evolution reaction, and formation of crystalline oxide occurs during electrocatalysis.
Towards routine organic structure determination using Raman microscopy
Authors: Malenfant Jason , Kuster Lucille , Gagné Yohann , Signo Kouassi , Denis Maxime , Canesi Sylvain , Frenette Mathieu
Published: November 2023

Raman microscopy can reveal a compound-specific vibrational “fingerprint” from micrograms of material with no sample preparation.
Thermally activated delayed fluorescence in a deep red dinuclear iridium(iii) complex: a hidden mechanism for short luminescence lifetimes
Authors: Pander Piotr , Zaytsev Andrey V. , Sil Amit , Baryshnikov Glib V. , Siddique Farhan , Williams J. A. Gareth , Dias Fernando B. , Kozhevnikov Valery N.
Published: November 2023

Thermally activated delayed fluorescence (TADF) is found to play an important role in accelerating the rate of radiative decay in luminescent iridium(iii) complexes, shown in this instance for dinuclear complexes formed with high stereoselectivity.
On-capillary alkylation micro-reactor: a facile strategy for proteo-metabolome profiling in the same single cells
Authors: He Yingyun , Yuan Huiming , Liang Yu , Liu Xinxin , Zhang Xiaozhe , Ji Yahui , Zhao Baofeng , Yang Kaiguang , Zhang Jue , Zhang Shen , Zhang Yukui , Zhang Lihua
Published: November 2023

An on-capillary alkylation micro-reactor (OCAM) was developed for parallel measurement of proteome and metabolome in the same single cells, providing a new avenue for studying system biology at single-cell level.
Honeycomb-like hollow carbon loaded with ruthenium nanoparticles as high-performance HER electrocatalysts
Authors: Ji Peng-Cheng , Teng Yang , Li Hong-Cheng , Guan Ming-Yun , Jia Hai-Lang
Published: November 2023

A honeycomb-like N-doped hollow carbon material loaded with a low content of ruthenium nanoparticles was prepared as an efficient HER catalyst, and its performance is even superior to that of commercial Pt/C.
Pure measures of bending for soft plates
Authors: Virga Epifanio G.
Published: November 2023

This paper shows that pure measures of bending for soft plates can be defined by introducing the class of bending-neutral deformations, which represent finite incremental changes in the plate's shape that do not induce any additional bending.
Reply to the ‘Comment on “Enhancing the output performance of hybrid nanogenerators based on Al-doped BaTiO3 composite films: a self-powered utility system for portable electronics”’, by A. Tkach and O. Okhay, J. Mater. Chem. A, 2023, 11, D3TA01041D
Authors: Dudem Bhaskar , Bharat L. Krishna , Patnam Harishkumarreddy , Mule Anki Reddy , Yu Jae Su
Published: November 2023

With this contribution, we reply to the Comment by Tkach et al. on our publication in J. Mater. Chem. A, 2018, 6, 16101. For that, we provide additional experimental evidence including the structural and material characteristics of ABTO.
The promotional effect of multiple active sites on Fe-based oxygen reduction electrocatalysts for a zinc–air battery
Authors: Li Zhiwen , Xie Yan , Gao Jianxin , Zhang Xiaoke , Zhang Jia , Liu Yu , Li Gao
Published: November 2023

The Hm/Cy@C-900 catalyst exhibits a ORR performance (E1/2 0.845 V vs. RHE), and its equipped zinc–air battery reaches a power density of 192 mW cm−2@260.7 mA cm−2, which is attributed to the promotional effect of FeSx and Fe3C clusters with FeNx sites.
Perylene-diimide for organic solar cells: current scenario and prospects in molecular geometric, functionalization, and optoelectronic properties
Authors: Murugan Pachaiyappan , Ravindran Ezhakudiayan , Sangeetha Vajjiram , Liu Shi-Yong , Jung Jae Woong
Published: November 2023

This review highlights key features of PDA-NFA: molecular design, diverse grafting sites, advanced synthesis, morphology control, and optimized device performance. This review provides a vision for high-performance PDA-NFA for NF-OSCs.
Simultaneous upcycling of PET plastic waste and CO2 reduction through Co-electrolysis: a novel approach for integrating CO2 reduction and PET hydrolysate oxidation
Authors: Kilaparthi Sravan Kumar , Addad Ahmed , Barras Alexandre , Szunerits Sabine , Boukherroub Rabah
Published: November 2023

The paper reports on the concurrent electrochemical generation of formate through CO2 reduction (cathode) and polyethylene terephthalate (PET) hydrolysate oxidation (anode).
An anthraquinone-based covalent organic framework for highly reversible aqueous zinc-ion battery cathodes
Authors: Li Lihua , Yang Haohao , Wang Xin , Ma Yinghu , Ou Weizhi , Peng Hui , Ma Guofu
Published: November 2023

TfDa-COF and TpDa-COF were used for ZIB cathodes to investigate the essential relationship between the active group and electrochemical properties. The dominance of the anthraquinone groups for coordination Zn2+ was showed by comparing the CV curves.
Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers
Authors: Ross Fiona A. , Hawley Simon A. , Russell Fiona M. , Goodman Nicola , Hardie D. Grahame
Published: November 2023

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status activated by increases in AMP or ADP relative to ATP. Once activated, it phosphorylates targets that promote ATP-generating catabolic pathways or inhibit ATP-consuming anabolic pathways, helping to restore cellular energy balance. Analysis of human cancer genome studies reveals that the PRKAA2 gene (encoding the α2 isoform of the catalytic subunit) is often subject to mis-sense mutations in cancer, particularly in melanoma and non-melanoma skin cancers, where up to 70 mis-sense mutations have been documented, often accompanied by loss of the tumour suppressor NF1. Recently it has been reported that knockout of PRKAA2 in NF1-deficient melanoma cells promoted anchorage-independent growth in vitro, as well as growth as xenografts in immunodeficient mice in vivo, suggesting that AMPK-α2 can act as a tumour suppressor in that context. However, very few of the mis-sense mutations in PRKAA2 that occur in human skin cancer and melanoma have been tested to see whether they cause loss-of-function. We have addressed this by making most of the reported mutations and testing their activity when expressed in AMPK knockout cells. Of 55 different mis-sense mutations (representing 75 cases), 9 (12%) appeared to cause a total loss of activity, 18 (24%) a partial loss, 11 (15%) an increase in phenformin-stimulated kinase activity, while just 37 (49%) had no clear effect on kinase activity. This supports the idea that AMPK-α2 acts as a tumour suppressor in the context of human skin cancer.
Speech, Sign, or Both? Factors Influencing Caregivers' Communication Method Decision Making for Deaf/Hard of Hearing Children
Authors: Jones Maranda K. , Roberts Megan Y.
Published: November 2023

Purpose:

Caregivers of deaf/hard of hearing infants are faced with challenging decisions regarding their child's communication method. The purpose of the current research note is to characterize the advice that caregivers receive and value as well as the factors that influence caregivers' decision making.

Method:

The current study enrolled 105 caregiver–child dyads, including children between 12 and 18 months of age with bilateral, congenital hearing loss. All children were exposed to spoken language, and 63.81% of children were also exposed to sign language. Caregivers completed the “Making Decisions About Sign, Speech, and Multilingualism Survey” (Crowe et al., 2014).

Results:

Caregivers most frequently received advice to use both speech and sign and highly valued advice from speech-language pathologists. When considering the use of speech, the factors that caregivers most frequently rated as
very important
were “My child's future academic success” (96.19%), “My child's future literary success” (95.24%), and “My child's future access to higher education” (95.19%). When considering the use of sign, the factors that caregivers most frequently rated as
very important
were “My child's ability to form friendships and future relationships” (82.52%), “My child's future literary success” (81.37%), and “My child's future academic success” (81.37%).

Conclusions:

Results of the current study suggest that throughout the decision-making process, caregivers' highest priority is understanding how their decisions will influence their child's future access to opportunities and relationships. Providers may consider discussing these factors early in the decision-making process to support caregivers' ability to make an informed choice regarding their child's communication method.
FPGA in the loop implementation of the PUMA 560 robot based on backstepping control
Authors: Fekik Arezki , Khati Hocine , Azar Ahmad Taher , Hamida Mohamed Lamine , Denoun Hakim , Hameed Ibrahim A. , Kamal Nashwa Ahmad
Published: November 2023

The objective of this article is to present the implementation of a backstepping control regulator on a Xilinx Zedboard Zynq FPGA using the HDL Coder tool through the FPGA in‐the‐loop option, and to study its effectiveness when applied to a three‐dimensional robotic manipulator model. The analysis is based on the application of the backstepping control law for the three degrees of freedom PUMA 560 model, through the development of a dynamic simulation model. The results of practical implementation using the FPGA in the loop technique demonstrate the effectiveness of the proposed method using the Xilinx Zedboard Zynq FPGA, which provides a useful insight into the benefits of using backstepping control laws in robotics applications.
Electromagnetically induced transparency in indirectly coupled high‐temperature superconducting resonators
Authors: Zheng Tianning , Huang Juntian , Wang Pengqi , Jiang Linan , Wei Bin
Published: November 2023

In this letter, electromagnetically induced transparency (EIT) is implemented in the microwave region with an experimental system composed of two indirectly coupled high‐temperature superconducting resonators. The transition condition between EIT and Autler–Townes splitting is analyzed, giving a physical explanation of this transition based on the superposition of dressed modes in a three‐level system. Benefit from the ultra‐low loss of superconducting circuit, it is experimentally shown that either EIT or Autler–Townes splitting can be explicitly achieved through control of the detuning between the two resonators and a group delay as high as 5 μs is obtained for the EIT case. This work suggests that high temperature superconducting circuit is a concise and explicit platform for investigating indirectly coupled resonators with standing‐wave modes and the physical mechanism underneath coherence phenomena in the microwave region.
Design of a multiparameter data acquisition and control system for in situ seabed observation base stations
Authors: Zhong Chao , Lu Jing'an , Kang Dongju , Liang Qianyong
Published: November 2023

With the exploration, development, and research of deep‐sea resources, there is an urgent need for long‐term and continuous observation data of the deep‐sea seabed boundary layer. The traditional method of deep‐sea seabed survey and sampling based on scientific research vessels has the discontinuity of observation data in space and time scales. There are some problems in the seabed in situ observation method based on the seabed observation network for low mobility and high operation and maintenance costs, restricting the in‐depth understanding of the dynamic change process of the deep‐sea floor. To solve the above problems, an open and modular data acquisition control system was designed based on an embedded system and signal processing technology. In terms of the physical, chemical, geological, and ecosystem characteristics of the seafloor or near the seafloor boundary layer, various functional sensors and instrumentation were matched to form an independent underwater integrated measurement or experimental device, eventually realizing in situ multiparameter and long‐time series observations of the seafloor. The system data acquisition and control test were completed through laboratory experiments, which verified the feasibility of the system design. The research showed important theoretical and technical reference significance for the exploration and development of resources in the submarine boundary layer and the promotion of deep‐sea scientific research.
Fostering Sustainable Community-Based Tourism in Marine and Coastal Regions: Examining the Influence of Destination Social Responsibility on Environmentally Responsible Behavior, Mediated by Destination Image
Authors: Fairuz Ramli Mona , Badarulzaman Nurwati
Published: November 2023

The study aims to explores the impact of Destination Social Responsibility (DSR) and Destination Image (DI) on Environmentally Responsible Behaviour (ERB)-based tourism. This study collected data using the convenience sampling method, specifically through a survey administered to residents in a community of marine parks. Initially, a total of 300 questionnaires were distributed, resulting in the return of 200 completed surveys. After removing incomplete surveys, a total of 195 usable questionnaires have been included in the analysis.Given that the study employed composite measures and focused on predictive as well as explanatory purposes, the researchers utilized Partial Least Squares-Structural Equation Modeling (PLS-SEM 4) to test the developed model. Moreover, the findings suggest that DSR positively influenced both ERB and DI. However, DI did not significantly impact ERB and did not act as a mediator between DSR as well as ERB. The findings show the local population’s involvement entails mitigating detrimental environmental impacts in coastal and marine areas.The local community, as a key stakeholder in a tourism destination, plays a significant role in promoting sustainable tourism growth in the area.The study offers valuable insights for destination management organizations as well as stakeholders in formulating environmental policies to promote sustainable development in Redang’s community.
Community-Based Village Management Independence In Efforts to Create Sustainable Tourism (Panglipuran Tourism Village Phenomena)
Authors: Sulistyo Agung , Fatmawati Indah , Nuryakin
Published: November 2023

Tourist behavior change in choosing tourist attractions have made tourism villages the prima donna. The presence of a tourist village is interpreted as an integration between interest and social activity with the leading role played by the community. Through these activities, the part of tourism in community empowerment is something that needs attention. This study aims to find the meaning of Independence in managing tourist villages carried out by the community. This study uses a qualitative design through a phenomenon. This study tries to explore the community’s experience as a tourist village manager and the impacts that arise. The data collection process was carried out through semi-structured interviews with five informants. This research showed the meaning of community independence and its impact on managing tourist villages, including community self-confidence, community commitment, community economic empowerment and knowledge transfer. Thus, good management will provide positive results for the village’s and its people’s development. Several studies strengthen the argument for the role of the community as managers of regional potential. However, only some studies have raised the issue of community independence in managing tourist villages. Besides that, the conclusions of this study can also provide the guidance needed to develop regional potential, especially in tourism villages.
Investigating The Determining Factors of Tourist Revisit Intention in a Natural-based Tourism Destination
Authors: Fatmawati Indah , Olga Frido
Published: November 2023

Tourism is one of the growing sectors in Indonesia. Natural-based tourism is one of the most attractive tourism destinations among various tourism types in Indonesia. Investigating factors influencing tourist revisit intention in a natural-based tourism destination is interesting since it could reveal what factors drive tourists to revisit a particular destination they have visited. This study aims to analyze the influence of environmental quality, attractiveness, accessibility, facilities, and tourist satisfaction on tourist objects’ revisit intention. We use a quantitative approach and an explanatory design to test the proposed hypothesis. Respondents in this study were tourists who had visited Sarangan Lake, located in Magetan, East Java. The sampling method uses purposive sampling, and the final usable responses were 168 respondents. The analytical tool used in this research is Structural Equation Modelling (SEM) with the AMOS application program. Results indicated that environmental quality, attractiveness, accessibility, and facilities positively affect tourist satisfaction. Furthermore, tourist satisfaction positively impacts tourist revisit intention. Several research recommendations were discussed in our study.
The contribution of agricultural crop production towards the economic growth of Indonesia’s agricultural sector
Authors: Fery Purba Samuel , Yulianti Astrina , Astana Satria , Deden Djaenudin Raden , Hariyadi  , Maruli Timothy Vincent Simandjorang Bonataon , Haradongan Fedrickson , Istriningsih
Published: November 2023

The agricultural sector is annually included in the top three after the manufacturing sector and wholesale and retail trade sectors as Indonesia’s largest contributor to gross domestic product (GDP). The average contribution of the agricultural sector to the country’s income is around 11–13% of total GDP. The GRDP of the agricultural sector (AgriGRDP) is an indicator of the economic growth of Indonesia’s agricultural sector. This study aims to examine the contribution of plantation crop production (PPC), food crop production (PFC), horticultural crop production (PHC), and farmer terms of trade (FTT) to the AgriGRDP. This study uses secondary data sourced from BPS-Statistics Indonesia. This research method uses panel data regression analysis with time series data for 2018–2021 and cross-sectional data from 33 provinces in Indonesia, resulting in 132 observations. The results of this study found that the best econometric model to answer the research objectives is the random effect model (REM). The findings of this study indicate that simultaneously and partially, the variables PPC, PFC, PHC, and FTT have a significant positive effect on AgriGRDP. An increase in PPC, PFC, PHC, and FTT will increase Indonesia’s AgriGRDP.
Optimization model of maize production in various land use in Banten province
Authors: Siagian Viktor , Eka Putra Wawan , Salim Zamroni , Ragimun
Published: November 2023

The area of the maize harvest in Banten Province in 2020 was 16,676 ha with a production of 111,903 tons with productivity of 6,71 tons/ha. The objectives of this study are 1) To analyze the existing maize farm in Banten Province, and 2) To analyze the optimization of maize production in Banten Province. The study method used survey methods, with purposive sampling at the farmer level. Methods of data analysis using qualitative and quantitative analysis. The qualitative analysis used descriptive tabulation. Quantitative analysis using Geographic Information System (GIS), B/C ratio analysis and Linear Programming. The results of this study were: 1) The productivity of maize is 5,112 tons/ha, with the plant pattern being paddy - maize – fallow in rice field rainfed. The value of the B/C ratio5.6 it is mean that maize farming is profitable. 2) The optimum value of maize production in Banten Province is 1,533,600 tons of a dry shell, which is obtained from the average productivity of maize in upland areas of 5,112 kg/ha and the optimal planting area of 300,000 ha of upland land. Suggestions for maximizing maize production done by optimizing upland land.
Optimization of Production Factors in Organic Rice Farming in Sleman Regency, Yogyakarta
Authors: Triyono  , Al Uth’aini Toha , Nur Mila Amalia , Fauzi bin Kamrudin Mohd , Mamnuah
Published: November 2023

Rice is a promising commodity to be cultivated organically but still requires attention in the optimal use of production factors to achieve maximum results. The control of production factors is still limited in number by farmers while high production and profits are expected. The purpose of this study was to determine the factors of production, costs, and profits and to analyse the allocation of optimal use of production factors to achieve maximum profit in organic rice farming in Sleman Regency. Farming data were obtained from 70 organic rice farmers and analysed using linear programming methods. The results show that the use of production factors during the two growing seasons showed that the average land use was 1,555 m2, the use of seeds was not in accordance with the recommendations, more workers used outside the family, dominant farmers used solid organic fertilizers and liquid organic fertilizers as support. The average total cost incurred by farmers is IDR. 2,540,263 and IDR. 2,622,826 with an average profit of IDR. 2,414,237 and IDR. 2,181,8888. Optimization analysis shows that the use of land production factor costs is optimal, while the labour cost, seeds, solid organic fertilizers, and liquid organic fertilizers is still not optimal.
Production Risk Analysis for Organic Cabbage Farming in Semarang District, Central Java
Authors: Rahmawati Nur , Yogatama Candra , Winahyu Wulansari , Binti Kasim Anisah
Published: November 2023

There is some risk and uncertainty involved with purchasing organic cabbage. Farming is highly susceptible to natural phenomena such as high rainfall and pest infestations. It will have consequences for the development of the harvested area, and fluctuations in production can indicate a risk to agricultural production. This study aims to determine the factors that influence organic cabbage production and to determine the factors that affect the risk of organic cabbage production in Getasan District. The Semarang Regency, where this study was conducted, is the largest cabbage market. A total of 73 farmers were selected using a census-based sample from four INOFICE-certified organic farmer groups: Batur Village, Wates Village, Tajuk Village, and Kopeng Village. The analysis method utilized the Just and Pope production risk function and the Cobb-Douglass type production function. The Cobb-Douglass production function analysis revealed that land area, seeds, manure, and cropping patterns all positively and substantially affected organic cabbage production, but only to a limited extent. According to the Just and Pope production risk function, the risk associated with farming organic cabbage could be mitigated by increasing land area and diversity in cropping patterns.
Customer Motivation in the Purchase of Halal-Certified Chicken Products through Online Delivery Applications in Yogyakarta
Authors: Widodo  , Chandra Purnomo Rasyid , Susanti Wiwi , Wan Ibrahim Nik Rahila
Published: November 2023

Halal food is currently increasing in popularity among both Muslim and non-Muslim consumers. Halal food can be ordered directly or through online delivery applications, a popular trend. The process of ordering food using online applications saves time. However, it has limitations due to customers’ lack of direct observation, particularly Muslims. This study examined the customers’ motivation to choose online delivery applications for halal products at fast-food restaurants, even though they cannot directly observe the product preparation. The research was carried out in Bantul, The Special Region of Yogyakarta. Data were collected from 65 respondents utilizing a questionnaire distributed via a Google Form link. The findings revealed that taste, utility, and time savings were very strong motivators to purchase chicken meat. Furthermore, factors such as halal certification, adherence to Islamic principles, and blessings of halal food were categorized as strong to motivate customer purchasing. Nutritional requirements were the only factor with a moderate categorization for motivating fast-food chicken restaurant customers. While most fast-food chicken restaurants are already halal-certified, online delivery services frequently do not provide the information. It is suggested that each business provide more detailed product information on online delivery platforms.
Growth and Yield of Maize by Nitrogen and Potassium Inorganic Fertilizers Application to Fluventic Eutrudepts
Authors: Joy Benny , Yuniarti Anni , Priyanka  , Khairul Hakim Fardian , Taufik Imam , Jiwa Wibawa Rangga , Tri Wahyu Gunes
Published: November 2023

Maize production requires nutrients so that the soil becomes fertile and makes it easier for plants to grow well. It has been known that potassium nutrient enhances the carbon cycle in plant to maintain the development of plant and so on the yield quantity. This test was carried out from November 2022 to March 2023 on Fluventic Eutrudepts Located in Jatinangor. This test was carried out using a Randomized Block Design (RBD), which consisted of seven combinations of inorganic compound fertilizer nitrogen and potassium (NK) dose treatments. Each treatment was repeated three times. The test results showed that a dose of 1 ¾ NK accompanied by 1 dose of single nitrogen and phosphor (NP) could significantly increase maize yields compared to the control or without the addition of solid inorganic fertilizer NK inorganic fertilizer. The effect of giving solid inorganic fertilizer NK 1 ¾ dose of inorganic fertilizer significantly increase the yield of corn plants compared to the control treatment (without NK).
Assessing Seismic Fragility of Low-Rise RC Buildings by means of Incremental Dynamic Analysis (IDA)
Authors: Sangadji Senot , Safarizki Rida Handiana Devi , Safarizki Hendramawat Aski
Published: November 2023

The modern era witnessed an urbanization and economic growth concentrated in urban areas. Despite an increase in welfare, this receives a greater threat when an earthquake occurs. This research aims to assess the structural risk of low to medium-rise reinforced concrete building structures, commonly built in developing countries. This research was carried out by performing an incremental dynamic analysis (IDA) od an existing building model. In this analysis, the structural model was given a set of dynamic earthquake loads which were increased in magnitude according to certain scale rules until the structure experienced nonlinear behavior and reached a near collapse condition. Five artificial accelerogram recordings were applied on the structure after matching with the spectral response of the target location of the structure. From the analysis, the IDA curves were obtained which describes the global dynamic behavior of the structure, namely displacement due to earthquake lateral loads. Then the damage limits were determined on the IDA curve based on the HAZUS criteria. Then the seismic risk was expressed by constructing a seismic fragility curve. This curve states the probability of exceeding certain damage limits due to variation in earthquake intensity during the service life of the structure.
The Efficiency of Manufacturing 3D Printed Part by Using Resin Polymer
Authors: Bintara Redyarsa Dharma , Andoko Andoko , Suprayitno Suprayitno , Pradana Yanuar Rohmat Aji , Lai Jing-Yiih , Maulana Fiki , Yahya Haydar
Published: November 2023

The strength of 3D printed part is an important factor that must be considered before carrying out a product design. Moreover, manufacturing speed was also as key of successfully product design. The main focus of this study was to analyze the strength of 3D printed part and reduce the time manufacturing processing for getting the optimal design. The specimen models were designed according to ASTM D368-IV standards and printed using a 3D printer device. During the printing process, the infill density was varied into two different types, 0% and 100%. Meanwhile the main material used as a base material was Polylactic Acid or PLA which has an initial diameter of 1.75 mm. Furthermore, time consumption of manufacturing process was recorded, whereas the strength of specimens was observed using universal tensile test machine. The specimen model, especially for infill density 0% were added the resin polymer before carry out the tensile test. The results showed that the highest [1]tensile strength was occurred on the specimen that had the infill density of 100% without any addition of resin polymer. Besides that, the time consumption (infill density 0%) was showed significantly reduce than specimen that had infill density of 100%
Pulmonale Hypertonie assoziiert mit Linksherzerkrankungen (Gruppe 2)
Authors: Schmidt Kai Helge , Bikou Olympia , Blindt Rüdiger , Bruch Leonhard , Felgendreher Ralf , Hohenforst-Schmidt Wolfgang , Holt Stephan , Ladage Dennis , Pfeuffer-Jovic Elena , Rieth Andreas , Schmeisser Alexander , Schnitzler Katharina , Stadler Stefan , Steringer-Mascherbauer Regina , Yogeswaran Athiththan , Kuebler Wolfgang M.
Published: November 2023

Die pulmonale Hypertonie in Verbindung mit Linksherzerkrankungen (PH-LHD) bildet in der klinischen Klassifikation die Gruppe 2 der pulmonalen Hypertonie ab. Hämodynamisch zählt zu dieser Gruppe die isoliert postkapilläre pulmonale Hypertonie (IpcPH) und die gemischt post- und präkapilläre pulmonale Hypertonie (CpcPH). Die PH-LHD ist durch einen mPAP > 20 mmHg und einen PAWP > 15 mmHg definiert, zur Differenzierung zwischen IpcPH und CpcPH wird der pulmonalvaskuläre Widerstand (PVR) mit dem Grenzwert von 2 Wood Units (WU) herangezogen. Ein PVR von größer 5 WU weist auf eine dominierende präkapilläre Komponente hin. Die PH-LHD ist die häufigste Form der pulmonalen Hypertonie, ursächlich führend ist die Linksherzinsuffizienz mit erhaltener (HFpEF) oder reduzierter Ejektionsfraktion (HFmrEF, HFrEF), Herzklappenerkrankungen und seltener angeborene Herzfehler. Das Vorhandensein eines pulmonalen Hypertonus geht im gesamten Spektrum der Linksherzerkrankungen mit einer erhöhten Symptomlast und schlechterem Outcome einher. Eine besondere Herausforderung stellt die Differenzierung zwischen der pulmonalen Hypertonie der Gruppe 1 mit kardialen Komorbiditäten und der PH-LHD, besonders infolge der HFpEF dar. Therapeutisch kann zum jetzigen Zeitpunkt noch keine generelle Empfehlung für den Einsatz von PDE-5-Inhibitoren bei HFpEF-assoziierter CpcPH gegeben werden. Für die Anwendung von PAH-Medikamenten bei der IpcPH gibt es aktuell keine belastbare Rationale, ebenso wird die Therapie mit Endothelin-Rezeptor-Antagonisten oder Prostazyklin-Analoga bei allen Formen der PH-LHD nicht empfohlen.
Pulmonale arterielle Hypertonie bei Erwachsenen mit angeborenen Herzfehlern – Teil I
Authors: Kaemmerer Harald , Diller Gerhard Paul , Dähnert Ingo , Eichstaedt Christina A. , Eicken Andreas , Freiberger Annika , Freilinger Sebastian , Geiger Ralf , Gorenflo Matthias , Grünig Ekkehard , Hager Alfred , Herberg Ulrike , Huntgeburth Michael , Kaemmerer Ann-Sophie , Kozlik-Feldmann Rainer , Lammers Astrid , Nagdyman Nicole , Michel Sebastian , Schmidt Kai Helge , Uebing Anselm , von Scheidt Fabian , Apitz Christian
Published: November 2023

Die Zahl der Erwachsenen mit angeborenen Herzfehlern (AHF) steigt ständig und liegt in Deutschland aktuell bei etwa 360.000. AHF sind häufig mit einer pulmonalarteriellen Hypertonie (PAH) assoziiert, die sich bei unbehandelten AHF teils schon frühzeitig entwickelt. Trotz einer zeitgerechten Behandlung des AHF persistiert eine PAH nicht selten bzw. entwickelt sich im höheren Lebensalter neu und ist mit erheblicher Morbidität und Letalität behaftet.

Die überarbeiteten Leitlinien der European Society of Cardiology/European Respiratory Society 2022 für die Diagnose und Behandlung der PAH stellen einen wesentlichen Beitrag zur optimierten Versorgung der Betroffenen dar. Im vorliegenden Artikel soll der Abschnitt zur PAH assoziiert mit AHF aus den Leitlinien zusammengefasst und kommentiert werden.
Vagusnervstimulation (VNS) als Behandlungsoption für
Depressionen
Authors: Kavakbasi Erhan , Baune Bernhard T.
Published: November 2023

Einführung Depressionen sind häufig und zeigen bei einem Drittel
der Fälle einen therapieresistenten und chronifizierten Verlauf. Die
invasive Vagusnervstimulation (VNS) ist eine langfristige
Zusatzbehandlungsoption, die in den letzten Jahren zunehmend häufig
angewandt wird. Eine CE-Zertifizierung für die Behandlung der
chronischen und therapierefraktären Depression besteht seit 2001.
Methoden Basierend auf einer systematischen Literaturrecherche geben wir in
diesem narrativen Review einen Überblick mit klinischem Schwerpunkt
über die invasive VNS als Behandlungsoption bei der Depressionen.
Ergebnisse Nach psychiatrischer Indikationsstellung und Aufklärung wird
in einem kurzen operativen Eingriff der Impulsgeber im Bereich der linken Brust
implantiert. Die Einstellung der Stimulationsparameter erfolgt
ambulant-psychiatrisch in den ersten Wochen nach der OP. Das VNS-System wird
zunächst in 3-, später in 6-monatigen Intervallen kontrolliert.
Die Stimulation erfolgt für 30 Sekunden zwischen 5-minütigen
Intervallen. Stimulationssynchrone Heiserkeit ist die häufigste
Nebenwirkung. Steigerung noradrenerger und serotonerger Transmission im Gehirn
und anti-inflammatorische Effekte werden als Wirkmechanismen diskutiert. Der
Behandlungseffekt tritt verzögert nach 6–12 Monaten ein. Die
kumulative Responserate nach 5 Jahren liegt für die VNS plus
Standardbehandlung bei ca. 67,6% im Vergleich zu 40.9% bei
Standardbehandlung ohne VNS. Langfristige positive Effekte auf
Lebensqualität, Kognition, Morbidität und Mortalität
wurden beschrieben. Schlussfolgerung Die VNS ist eine langfristige, sichere
Behandlungsoption bei schwer betroffenen Depressionspatienten mit positivem
Effekt auf Symptomschwere, Lebensqualität und kognitive Funktion.