bluuebunny/crossref_metadata_2025 huggingface dataset:
An examination of self-esteem in the context of general personality functioning
Authors: Kawash George , Clewes Janet L. , Keating Leo
Published: May 2024

The Coopersmith Self-Esteem Inventory (SEI) and the Children's Personality Questionnaire (CPQ) or the High School Personality Questionnaire (HSPQ) were administered to 350 children and adolescents. An obliquely rotated factor analysis of the matrix of intercorrelations amoing SEI factors and CPQ/HSPQ factors allowed for an examination of self-esteem as a general vs. specific construct and for an enquiry into its relationship with other well established personality factors. The results suggested that a hierarchical model of self-esteem, with a general (global) factor at the second-order is a defensible position, and that self-esteem can be differentiated clearly from other personality factors while retaining significant correlations with some of them, most notably anxiety.
The rejection of the hypothesis of complete independence prior to conducting a factor analysis
Authors: Reddon John R.
Published: May 2024

Two tests of complete independence were compared in terms of relative power efficiency on 50 equi-correlation matrices and 26 published data sets. Λ1 a test based on Fisher's tanh-1 (r) transformation had greater power efficiency than, Λ0 a test based on -log|R| with finite sample corrections. Consequently, sample size requirements for rejecting P=I should be determined from Λ1 instead of Λ0. In addition, Baggaley's estimate of Q=-log|R|/k from the average absolute off-diagonal correlation was compared with a root mean square estimate of Q. The root mean square estimate was preferable but also demonstrated considerable bias. Because of the bias in estimating Q from the off-diagonal correlations, because Λ1 has greater relative power efficiency for P=I than ?0, and because the test statistic for Λ1 can be approximated from the root mean square off-diagonal correlation, it is preferable to tabulate power results for Λ1 as a function of the average correlation instead of Λo.
Determining a 16 PF profile and four-point codes for mental-health center clients
Authors: Williams Katharine B. , Wallbrown Fred H. , Reuter Ellen K.
Published: May 2024

This study was designed to determine the incidence of 16PF four-point codes and overall 16 PF profile for clients assigned to the adult outpatient department in a comprehensive community mental-health clinic. Subjects consisted of 282 clients who were seen for intake during a four-month time period. Form A of the 16 PF was administered to clients at the time of intake. The incidence of four-point codes was determined, and means and standard deviations were computed for the sample. The mean scores of this mental-health center group were compared to the means reported by Reuter, Wallbrown, and Wallbrown (1985) for a private-practice group, as well as the means for the standardization sample.
Sex and age interactions with the structured interview global Type A behavior pattern and hostility in the prediction of health behaviors
Authors: Dielman T. E. , Leech S. L. , Miller M. V. , Moss G. E.
Published: May 2024

A health-behavior survey and the Type A structured Interview (SI) were administered to a general-population sample of 903 adults. Self-reports of nine health behaviors were used as dependent variables. Multivariate analyses of variance followed by two series of three-way analyses of variance were conducted by age, sex, and SI-assessed global Type A (or hostility). There were main effects and/or two-way interactions for all of the dependent variables. Global Type A behavior and hostility were positively related to higher frequency-quantity of alcohol use, more frequently exceeding the speed limit, fewer hours of sleep, and less-frequent breakfast. Three-way interactions indicated that men under the age of 60 who were classified as Type Al reported a higher frequency-quantity of alcohol use than any other subgroup. The highest percentage of current cigarette smokers was among the high-hostility young men. Implications for behavior-change programs and research are discussed.
ANALYSIS OF ELECTRONIC AND DIGITAL INFORMATION SOURCES USED BY FARMERS IN AFGHANISTAN
Authors: Inamullah  , Usman Muhammad
Published: May 2024

Agriculture is one of the prominent income sources for the farmers in Afghanistan. In order to get higher production farmers, utilize different information sources to meet their information needs. In this study, the use of electronic and digital media sources is explored quantitatively from the district Kama of Nangarhar province. Total 178 randomly selected farmers were interviewed using validated and reliable interview schedule. Collected data were analyzed using Statistical Package for Social Sciences (SPSS). Results found positive feedback for agriculture-related T.V. programs addressing farming community needs, but radio programs have slightly lower satisfaction levels. Additionally, a substantial portion of respondents use the internet, while many do not use Facebook and WhatsApp, underscoring the importance of catering to diverse technological preferences in disseminating agricultural information. This study urged promotion of Facebook groups and WhatsApp groups by the agriculture department to disseminate agricultural information among farmers to meet their information needs
Online Support Management System for University of Antique
Authors:   College of Computer Studies, University of Antique, Sibalom, Antique, Philippines, Mission Roger
Published: May 2024

This paper discussed the development of an Online Support Management System to have a centralized system to support the information technology needs of every department of the University of Antique, in effect, to support the needs of the students. The system was developed using the modified Software Development Life Cycle Waterfall Model using six phases – Conceptualization, Technical Feasibility, Development, Pilot Testing, Creation of User’s manual, and Evaluation of Online Support Management System. Each phase must be completed before the next phase can begin and there is no overlapping in the phases.

The researcher anchors the study on Research and Development (R&D) which aims to create a new body of knowledge about existing products or processes, or the creation of an entirely new product. Unstructured interviews, document analysis, and modified survey-questionnaire adapted from ISO/IEC 25010: 2011 Systems and Software Quality Requirements and Evaluation (SQuaRE) - System and software quality models had been conducted for data collection.

The findings showed that three groups of the respondents were satisfied with the features and capabilities of the Online Support Management System and complied with the requirements or specifications based on ISO/IEC 25010: 2011 standards.

Though the respondents are satisfied with their evaluation of the developed Online Support Management System, the result revealed that there was a significant difference noted in the evaluations of the respondents. This result implies that the evaluation made by the three groups of respondents significantly differs from one another in terms of functional suitability, performance efficiency, compatibility, usability, reliability, security, and maintainability.
Design of a Secured Multimedia Transmission Scheme over Heterogeneous Wireless Systems
Authors:   Multimedia Engineering Department, Hannam University, Daejeon, South Korea, Islam Md. Rakibul , Bharti Preeti ,   Multimedia Engineering Department, Hannam University, Daejeon, South Korea, Caytiles Ronnie ,   Multimedia Engineering Department, Hannam University, Daejeon, South Korea
Published: May 2024

The evolution of wireless technologies has paved the way for the massively increasing availability of multimedia content in all forms from the Internet. Wireless networks consist of heterogeneous and overlapping coverages of multiple access technologies. The transmission of multimedia contents in the open wireless network system such as the Internet will always be vulnerable to security threats and possible adversary attacks. This paper deals with the analysis and design of a robust transmission security scheme capable of protecting the handshake of devices over heterogeneous wireless systems. It incorporates the features of both symmetric and asymmetric encryption schemes to ensure and guarantee a secured multimedia content transmission.
Digital Gaming: Implication to Undergraduate Students’ Study habits, Academic Achievement and Time Management
Authors:   College of Graduate Studies, Palompon Institute of Technology, Palompon, Leyte, Philippines, Orioque Janet , Selpa Haide ,   College of Technology and Engineering, Palompon Institute of Technology, Palompon, Leyte, Philippines
Published: May 2024

Digital technology had a huge impact on the lives of the younger generation, particularly the students. Mobile and internet involvement are used to facilitate their socialization process. Time spent on a digital device is an important component of their lives. Their attraction to the digital world prevents them from concentrating on their studies. The main aim of this study was to examine whether undergraduate students are engaged in digital gaming and its effect on their study habits and academic achievement with time management as a mediating variable. It employed a descriptive-correlational research design, utilizing questionnaires as an instrument in obtaining relevant data. The statistical treatment used were frequency, means, and Pearson r. Results showed that majority of the students spent high in digital gaming; had very good time management skills; good study habits and academic achievement. That is, frequency and length of time in digital gaming had no effect on students and academic achievement. Contributory of which is the students’ good time management, hence their academic achievement was significantly not affected. These results led the researchers to conclude the importance of time management among students. Generally, digital gaming cannot significantly affect the study habits and academic achievement of students especially those who possess good time management skills, this study can be investigated further to strengthen the findings.
Wireless Sensor Networks: A Descriptive Study on its Types, Topologies and Applications
Authors:   Multimedia Engineering Department, Hannam University, Daejeon, South Korea, Islam Md. Rakibul , Bharti Preeti ,   Multimedia Engineering Department, Hannam University, Daejeon, South Korea, Caytiles Ronnie ,   Multimedia Engineering Department, Hannam University, Daejeon, South Korea
Published: May 2024

The rapidly increasing demand for the applications of Wireless Sensor Networks (WSNs) has attracted researchers from various fields to explore the opportunities that this technology can offer. This paper aims to provide a descriptive study on the overview of WSNs, to discuss their types, the common topologies for structured networks, and their application in various fields. WSNs can be generally classified into five types, namely, terrestrial, underground, underwater, multimedia, and mobile. The WSNs topological structure is classified into point-to-point, star, tree, mesh, and hybrid. Among the WSN applications to be discussed are in the environment, medical and healthcare, home, military, disaster relief operations, transportation, logistics, industrial control, security, education, and entertainment.
Redeeming Capitalism
Authors: Jim Dupree
Published: May 2024

Redeeming Capitalism is an excellent primer of the practical, philosophical, and theological movement from historical to current times, reviewing the thinking that forms our contemporary view and practice of capitalism. In 13 succinct chapters, Barnes argues that capitalism should not be abandoned for another flawed economic theory but rather redeemed. Carefully integrating Scripture, case studies, and personal experience and drawing substantively on St. Thomas Aquinas’ cardinal  virtues et al, Barnes shows how the practice of capitalism has been corrupted into its current, self-focused form. Well footnoted with a seven-page bibliography, Barnes’ book draws upon both historic and contemporary sources to support his argument.
Humble Leadership: The Power of Relationships, Openness and Trust
Authors: Darin L. Gerdes
Published: May 2024

Edgar Schein, professor emeritus at MIT, is a wellestablished scholar in fields such as process consultation, organizational change, and organizational culture. He has published numerous books and articles in his more than 50 years in academia. His son, Peter Schein, is a co-founder and COO of the Organizational Culture and Leadership Institute. Humble Leadership is part of a progressive unfolding of Edgar Schein’s research on organizations. It follows closely on the heels of Humble Inquiry (2013), in which Schein argues that asking is superior to telling because it enhances trust and builds relationships, and Humble Consulting (2016), in which Schein applies this concept to organizational diagnosis. These books, in turn, were extensions of Helping (2009) which laid the groundwork for the other works.
Endings
Authors: Locke Larry G.
Published: May 2024

Review Board, Guidelines & Opportunities
“Raising the Needy from the Dust”: The Judeo-Christian Imperative
Authors: Mizrachi Murray , Freidman Hershey
Published: May 2024

Using the Bible, this article demonstrates that giving charity, as crucial as it is, is not a sufficient response to the impoverished because it deprives the receiver of dignity. Christians and other followers of the Bible have a greater responsibility than simply providing the underprivileged with donations of money or food to survive. The Bible dictates that we must find ways to generate jobs and provide employment for the poor so that they can escape their poverty with dignity. The purpose of many biblical laws such as leaving the gleanings, forgotten produce, and the corners of the field for the poor; forgiving debt; returning land to its original owners during the Jubilee year; lending money to the destitute; and others had the purpose of “raising the needy from the dust” (Psalms 113:7). More than offering a safety net, the Bible obligates believers to provide a ladder for the unfortunates of society to climb out of a cycle of poverty.
A Solid Foundation for Servant Leadership
Authors: McMahone Marty
Published: May 2024

Many Christians have identified servant leadership as the appropriate form of leadership for Christian disciples. Several writers have critiqued that perspective and suggested that modern servant leadership theory might not be built on sound biblical practices. In this article, the author will consider arguments against servant leadership as a Christian perspective, especially those proposed by Locke (2019). The author will acknowledge that there are some legitimate concerns raised but also argue that some of the expressed concerns may be overstated. Finally, the author will present a path forward toward a more nuanced connection between servant leadership and Christian thinking.
Marine resources compound with melanogenic regulatory properties: Especially seagrass, seaweed, and marine sponges as an anti-melanogenic activity
Authors: Utami Diah Tri , Setyowati Erna Prawita , Murti Yosi Bayu , Meiyanto Edy
Published: May 2024

Tyrosinase is a rate-limiting enzyme that is essential for the synthesis of melanin and controls pigmentation in the skin. The most common strategy in cosmeceutical products for skin lightening is the suppression of tyrosinase. Marine substances contain a variety of unique chemical compounds that have the potential to develop into new bioactive compounds as future medications for skin hyperpigmentation therapy. In this review, we summarize 55 compounds from marine resources that have been identified as active in inhibiting tyrosinase enzyme activity from research studies published up to April 2023. Those substances are classified to be very strong, strong, and moderate inhibit tyrosinase activity and melanin biosynthesis. Based on the IC50 value, there are 12 compounds that act as potential anti-melanogenic agents. 7-phloroeckol isolated from Ecklonia cava has the highest tyrosinase enzyme inhibitory activity with an IC50 value of 0.85 μM, while Arenarol isolated from Dysidea arenaria has the most active properties in reducing the synthesis of melanin with an IC50 value of <3 μM on B16 melanoma cells. We propose to present a new perspective on the discovery of metabolites from seagrasses, seaweeds, and marine sponges that can be applied as lead compounds in developing medications for anti-hyperpigmentation therapy through this review.
Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
Authors: Duewell Benjamin R , Wilson Naomi E , Bailey Gabriela M , Peabody Sarah E , Hansen Scott D
Published: May 2024

Phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), G-protein coupled receptors, and Rho-family GTPases. The mechanism by which PI3Kβ prioritizes interactions with various membrane-tethered signaling inputs, however, remains unclear. Previous experiments did not determine whether interactions with membrane-tethered proteins primarily control PI3Kβ localization versus directly modulate lipid kinase activity. To address this gap in our knowledge, we established an assay to directly visualize how three distinct protein interactions regulate PI3Kβ when presented to the kinase in a biologically relevant configuration on supported lipid bilayers. Using single molecule Total Internal Reflection Fluorescence (TIRF) Microscopy, we determined the mechanism controlling PI3Kβ membrane localization, prioritization of signaling inputs, and lipid kinase activation. We find that auto-inhibited PI3Kβ prioritizes interactions with RTK-derived tyrosine phosphorylated (pY) peptides before engaging either GβGγ or Rac1(GTP). Although pY peptides strongly localize PI3Kβ to membranes, stimulation of lipid kinase activity is modest. In the presence of either pY/GβGγ or pY/Rac1(GTP), PI3Kβ activity is dramatically enhanced beyond what can be explained by simply increasing membrane localization. Instead, PI3Kβ is synergistically activated by pY/GβGγ and pY/Rac1 (GTP) through a mechanism consistent with allosteric regulation.
Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics
Authors: Ose Nicholas James , Campitelli Paul , Modi Tushar , Kazan I Can , Kumar Sudhir , Ozkan Sefika Banu
Published: May 2024

We integrate evolutionary predictions based on the neutral theory of molecular evolution with protein dynamics to generate mechanistic insight into the molecular adaptations of the SARS-COV-2 spike (S) protein. With this approach, we first identified candidate adaptive polymorphisms (CAPs) of the SARS-CoV-2 S protein and assessed the impact of these CAPs through dynamics analysis. Not only have we found that CAPs frequently overlap with well-known functional sites, but also, using several different dynamics-based metrics, we reveal the critical allosteric interplay between SARS-CoV-2 CAPs and the S protein binding sites with the human ACE2 (hACE2) protein. CAPs interact far differently with the hACE2 binding site residues in the open conformation of the S protein compared to the closed form. In particular, the CAP sites control the dynamics of binding residues in the open state, suggesting an allosteric control of hACE2 binding. We also explored the characteristic mutations of different SARS-CoV-2 strains to find dynamic hallmarks and potential effects of future mutations. Our analyses reveal that Delta strain-specific variants have non-additive (i.e., epistatic) interactions with CAP sites, whereas the less pathogenic Omicron strains have mostly additive mutations. Finally, our dynamics-based analysis suggests that the novel mutations observed in the Omicron strain epistatically interact with the CAP sites to help escape antibody binding.
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
Authors: Cook Ashley L , Sur Surojit , Dobbyn Laura , Watson Evangeline , Cohen Joshua D , Ptak Blair , Lee Bum Seok , Paul Suman , Hsiue Emily , Popoli Maria , Vogelstein Bert , Papadopoulos Nickolas , Bettegowda Chetan , Gabrielson Kathy , Zhou Shibin , Kinzler Kenneth W , Wyhs Nicolas
Published: May 2024

Despite exciting developments in cancer immunotherapy, its broad application is limited by the paucity of targetable antigens on the tumor cell surface. As an intrinsic cellular pathway, nonsense- mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harboring truncating mutations. We developed and conducted a high throughput screen, based on the ratiometric analysis of transcripts, to identify critical mediators of NMD. This screen revealed disruption of kinase SMG1’s phosphorylation of UPF1 as a potent disruptor of NMD. This led us to design a novel SMG1 inhibitor, KVS0001, that elevates the expression of transcripts and proteins resulting from truncating mutations
in vivo
and
in vitro
. Most importantly, KVS0001 concomitantly increased the presentation of immune-targetable HLA class I-associated peptides from NMD-downregulated proteins on the surface of cancer cells. KVS0001 provides new opportunities for studying NMD and the diseases in which NMD plays a role, including cancer and inherited diseases.
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances
Authors: Qiu Jian , Voliotis Margaritis , Bosch Martha A , Li Xiao Feng , Zweifel Larry S , Tsaneva-Atanasova Krasimira , O'Byrne Kevin T , Rønnekleiv Oline K , Kelly Martin J
Published: May 2024

Hypothalamic kisspeptin (Kiss1) neurons are vital for pubertal development and reproduction. Arcuate nucleus Kiss1 (Kiss1ARH) neurons are responsible for the pulsatile release of gonadotropin-releasing hormone (GnRH). In females, the behavior of Kiss1ARH neurons, expressing Kiss1, neurokinin B (NKB), and dynorphin (Dyn), varies throughout the ovarian cycle. Studies indicate that 17β-estradiol (E2) reduces peptide expression but increases Slc17a6 (Vglut2) mRNA and glutamate neurotransmission in these neurons, suggesting a shift from peptidergic to glutamatergic signaling. To investigate this shift, we combined transcriptomics, electrophysiology, and mathematical modeling. Our results demonstrate that E2 treatment upregulates the mRNA expression of voltage-activated calcium channels, elevating the whole-cell calcium current that contributes to high-frequency burst firing. Additionally, E2 treatment decreased the mRNA levels of canonical transient receptor potential (TPRC) 5 and G protein-coupled K+ (GIRK) channels. When Trpc5 channels in Kiss1ARH neurons were deleted using CRISPR/SaCas9, the slow excitatory postsynaptic potential was eliminated. Our data enabled us to formulate a biophysically realistic mathematical model of Kiss1ARH neurons, suggesting that E2 modifies ionic conductances in these neurons, enabling the transition from high-frequency synchronous firing through NKB-driven activation of TRPC5 channels to a short bursting mode facilitating glutamate release. In a low E2 milieu, synchronous firing of Kiss1ARH neurons drives pulsatile release of GnRH, while the transition to burst firing with high, preovulatory levels of E2 would facilitate the GnRH surge through its glutamatergic synaptic connection to preoptic Kiss1 neurons.
D-CyPre: a machine learning-based tool for accurate prediction of human CYP450 enzyme metabolic sites
Authors: Yang Haolan , Liu Jie , Chen Kui , Cong Shiyu , Cai Shengnan , Li Yueting , Jia Zhixin , Wu Hao , Lou Tianyu , Wei Zuying , Yang Xiaoqin , Xiao Hongbin
Published: May 2024

The advancement of graph neural networks (GNNs) has made it possible to accurately predict metabolic sites. Despite the combination of GNNs with XGBOOST showing impressive performance, this technology has not yet been applied in the realm of metabolic site prediction. Previous metabolic site prediction tools focused on bonds and atoms, regardless of the overall molecular skeleton. This study introduces a novel tool, named D-CyPre, that amalgamates atom, bond, and molecular skeleton information via two directed message-passing neural networks (D-MPNN) to predict the metabolic sites of the nine cytochrome P450 enzymes using XGBOOST. In D-CyPre Precision Mode, the model produces fewer, but more accurate results (Jaccard score: 0.497, F1: 0.660, and precision: 0.737 in the test set). In D-CyPre Recall Mode, the model produces less accurate, but more comprehensive results (Jaccard score: 0.506, F1: 0.669, and recall: 0.720 in the test set). In the test set of 68 reactants, D-CyPre outperformed BioTransformer on all isoenzymes and CyProduct on most isoenzymes (5/9). For the subtypes where D-CyPre outperformed CyProducts, the Jaccard score and F1 scores increased by 24% and 16% in Precision Mode (4/9) and 19% and 12% in Recall Mode (5/9), respectively, relative to the second-best CyProduct. Overall, D-CyPre provides more accurate prediction results for human CYP450 enzyme metabolic sites.
Effect of iron saturation of bovine lactoferrin on the inhibition of hepatitis B virus in vitro
Authors: Zhou Haibo , Zhu Yiwei , Liu Ning , Zhang Wencui , Han Jianchun
Published: May 2024

Background

Hepatitis B virus (HBV) infection poses a major public health problem worldwide. Bovine lactoferrin (bLf) is a natural product that can inhibit HBV, but the effect of iron saturation on its resistance to HBV is unknown.

Aims

The purpose of this study is to investigate the impact of iron saturation of bLf against HBV.

Methods

HepG2 cells were cultured in DMEM high glucose containing 10% inactivated fetal calf serum, at 37 °C, in 5% CO2. MTT method was used to detect the cytotoxicity of bLf to HepG2 cells. Apo-bLf and holo-bLf were prepared from bLf. Iron saturation of these proteins was determined by atomic absorption spectrophotometry. Non-cytotoxic concentrations of candidate proteins were used in anti-HBV tests. Fluorescent quantitative polymerase chain reaction was used to detect HBV-DNA.

Results

The TC50 and TC0of bLf were 54.570 mg/ml and 1.997 mg/ml, respectively. The iron saturation of bLf, apo-bLf and holo-bLf were 10.29%, 8.42% and 85.32%, respectively. In this study, four non-cytotoxic concentrations of candidate proteins (1.5, 1.0, 0.5, and 0.1 mg/ml, respectively) were used to inhibit HBV in HepG2 cells. The results showed that 1.5 mg/ml bLf and 0.1 mg/ml holo-bLf effectively impaired the HBV-DNA amplification in HBV-infected HepG2 cells (P < 0.05). However, apo-bLf, and Fe3+ did not show the anti-HBV effects.

Conclusion

A total of 1.5 mg/ml bLf and 0.1 mg/ml holo-bLf could inhibit HBV-DNA in HepG2 cells. Complete bLf structure, appropriate concentration and iron saturation of bLf are necessary conditions for anti-HBV effects.
Estudio genético en variedades contrastantes a la sequía de Trigo candeal (Triticum turgidum var. durum L.) y su efecto en los componentes de rendimiento
Authors:   , Villarroel Muñoz Valentina
Published: May 2024

El trigo es una de las especies vegetales más antiguas cultivadas por el ser humano siendo un elemento esencial en la dieta de la mayoría de los habitantes del planeta. El trigo candeal (Triticum turgidum L. ssp. durum) representa solo una fracción de la producción total de trigo en el mundo, sin embargo, el trigo candeal chileno ha presentado una alta calidad y rendimiento que lo posiciona excepcionalmente en la industria agrícola. El cultivo de trigo candeal se ha visto históricamente afectado por las condiciones de sequía, comprometiendo no solo el desarrollo del cultivo sino que también su rendimiento. Se realizó un análisis genético de dos variedades de trigo con índices de tolerancia a la sequía contrastantes, con el objetivo de identificar genes asociados a una mayor tolerancia al estrés hídrico. Para ello se llevó a cabo un estudio transcriptómico basado en RNA-seq, que, acompañado con el uso de herramientas bioinformáticas, logró determinar los las funciones biológicas enriquecidas y los genes diferencialmente expresados de cada genotipo. Se reportó que, dentro de las funciones biológicas enriquecidas en condiciones de estrés hídrico, encontramos la síntesis de fitohormonas como ácido salicílico (SA) y ácido abscísico (ABA) y además la síntesis de metabolitos secundarios. Adicionalmente, a partir de los genes diferencialmente expresados del genotipo tolerante logramos identificar alta expresión de genes asociados a tolerancia a la sequía tales como AGAL1, RAB18, PLD y RCI3. Finalmente, cabe destacar que dentro del estudio de expresión diferencial encontramos genes no identificados que pueden ser de gran relevancia, abriendo la puerta para futuras investigaciones.
Relationship between Emotional Intelligence and Performance of Employees in Tertiary Institutions: The Mediating Role of Work Motivation
Authors: Ogunmola Oluleye Seun , Eguabor Roland Ohiozokhai , Ogbechi Daniel Adigwe , Ogbechi Chinaedum Daniel , Halim Henry Chiedu , Adow Anass Hmadelneel
Published: May 2024

Emotional intelligence is an important concept in organisational psychology that plays a significant role in the performance of employees. Despite this, empirical investigation on the mediating role of work motivation in the relationship between emotional intelligence and job performance is under-researched. Hence, this study examined the relationship between emotional intelligence and job performance with the introduction of work motivation as a mediating variable. The descriptive survey involved a heterogeneous sample of 370 non-academic staff from selected tertiary institutions in Ekiti State, Nigeria.  The relationship between EI and performance was tested using multiple linear regression, while the mediation model was analysed through the Hayes bootstrapping method in SPSS version 25. Findings from the study suggested self-emotion appraisal and regulation of emotion as statistically significant predictors of job performance. Work motivation was found to partially mediate the relationship between EI and job performance among the sample.
On the Generalization of the Number of Cyclic Codes Over the Prime Field GF(37)
Authors: Ongili Pancras , Mude Lao Hussein , Ndung’u Kinyanjui Jeremiah
Published: May 2024

Research has explored the characterization of cyclic codes over GF(P), where P is prime for P \(\le\) 23. However, no study has characterized GF(37). Additionally, no study has generalized enumeration of the number of cyclic codes of the cyclotomic polynomials un - 1 over GF(P). In particular, the generalization of the number of cyclic codes over GF(37) for un - 1 is also lacking in research. This study focused on the monic irreducible polynomials of un - 1 over the finite field GF(37) with the main objective of generalizing the enumeration of the number of distinct cyclic codes. The methodology involved determining the number of irreducible monic polynomials of the cyclotomic polynomial un - 1 over GF(37). These polynomials were found to correspond to the number of cyclotomic cosets of 37 mod n over GF(37). The study concluded that the number of cyclic codes over GF(37) can be generalized by NGF(37) = (37y + 1)Cxm \(\forall\)x, y, m \(\in\) Z+. The findings provide insights into abstract algebraic concepts in coding theory that can be used to generalize number of cyclic codes over a prime field GF(P).
The Effect of Corporate Social Responcibility, and Good Corporate Governance on The Financial Performance of The Health Sector Listed on The Indonesia Stock Exchange in 2019-2022
Authors: Widiyantara I Gede Agus , Pradnyani Ni Luh Putu Sri Purnama , Wasita Putu Aristya Adi
Published: May 2024

Financial performance is used as an assumption by investors in seeing the company's success rate. Maximizing financial performance is the same as paying attention to the prosperity of stakeholders. Therefore, companies do not only focus on profits, but need to pay attention to social and environmental conditions. Thus it can attract investors to invest in the company. The purpose of this study was to determine the effect of the implementation of Corporate Social Responsibility, Independent Commissioner, Audit Committee, Constitutional Ownership on the company's financial performance.The research method used is quantitative and qualitative research methods with secondary data. This research was conducted at health sector companies listed on the Indonesia Stock Exchange for the period of 2019 to 2022. The sample determination method used purposive sampling and obtained 52 observation samples. The data analysis technique used is multiple linear regression analysis with data presentation assisted by the SPSS 26 application. The results of this study indicate that the implementation of Corporate Social Responsibility has a positive effect on Financial Performance, Independent Commissioner has a positive effect on Financial Performance, Audit Committee has a positive effect on Financial Performance, while Constitutional Ownership has no effect on Financial Performance. These results are expected to be a consi­deration for investors in investing, because increasing financial performance is characterized by an increase in the company's share price, so that investors get optimal returns.
Palladium(II)‐Phosphine Complexes Supported on Magnetic Nanoparticles: Filtration‐Free, Recyclable Catalysts for Suzuki–Miyaura Cross‐Coupling Reactions
Authors: Shylesh Sankaranarayanapillai , Wang Lei , Thiel Werner R.
Published: February 2010

An organic‐inorganic hybrid heterogeneous nanocatalyst system was synthesized by covalent grafting a palladium dichloride complex of the type (L)2PdCl2 (L=trimethoxysilyl‐functionalized triphenylphosphine) on silica‐coated magnetic nanoparticles. It is a highly active and recyclable catalyst for the Suzuki–Miyaura cross‐coupling reaction. The new catalyst can easily be separated from the reaction mixture by applying an external magnetic field and can be recycled many times without any loss of activity.
Highly Efficient One‐Pot Synthesis of 2‐Substituted Quinazolines and 4H‐Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite
Authors: Maheswari C. Uma , Kumar G. Sathish , Venkateshwar M. , Kumar R. Arun , Kantam M. Lakshmi , Reddy K. Rajender
Published: February 2010

This communication describes a catalyst‐free synthesis of 2‐substituted quinazolines and 4H‐benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2‐quinazolines and 2‐substituted 4H‐benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.
Rhodium‐ and Palladium‐Catalyzed Hydroarylation of Propargylic Amines with Arylboronic Acids
Authors: Arcadi Antonio , Aschi Massimiliano , Chiarini Marco , Ferrara Giovanni , Marinelli Fabio
Published: February 2010

The hydroarylation of 3‐arylprop‐2‐yn‐1‐amine derivatives with arylboronic acids has been studied in the presence of rhodium or palladium catalysts. By using a rhodium‐based catalytic system, β,γ‐diarylallylamines were isolated in good yields. By contrast, the formation of the regiosomeric γ,γ‐diarylallylamines was achieved by means of a palladium catalyst in the presence of acetic acid. The complementary regioselectivity displayed by these two processes is a consequence of different catalytic cycles, involving respectively carborhodation or hydropalladation of the coordinated alkyne as key steps. Calculated charge distributions in the π‐complexes are in accord with the results obtained.
The First General and Selective Palladium(II)‐Catalyzed Alkoxycarbonylation of Arylboronates: Interplay among Benzoquinone‐Ligated Palladium(0) Complex, Organoboron, and Alcohol Solvent
Authors: Yamamoto Yoshihiko
Published: February 2010

Methoxycarbonylation of aryl‐ and alkenylboron compounds was performed using the palladium(II) acetate/triphenylphosphine [Pd(OAc)2/PPh3] catalyst with p‐benzoquinone as a stoichiometric oxidant in methanol at ambient temperature to obtain the corresponding methyl esters in good yields. A wide variety of functional groups including various carbonyl functionalities, nitrile, nitro, sulfone, and unprotected pyrrole rings were tolerated in the methoxycarbonlation, while the use of higher alcohols except for tert‐butanol afforded various p‐chlorobenzoates in moderate to high yields. The catalytic alkoxycarbonylation proceeded without any acid or base additive, and an oxidative transmetalation step is proposed to explain the exceptional efficacy of this protocol. DFT and MP2 calculations support the proposed mechanism.
Analysis of 2‐propanol in exhaled breath using in situ enrichment and cataluminescence detection
Authors: Wu Yayan , Wen Fang , Liu Da , Kong Hao , Zhang Chenhua , Zhang Sichun
Published: February 2010

We report a simple gaseous sensor for the sensitive detection of trace 2‐propanol in exhaled breath using in situ enrichment and cataluminescence detection method on the surface of nanomaterials. The influences of heating voltage and absorption time on the CTL intensity were discussed, respectively. In the selected conditions, the linear range of 2‐propanol concentration is 60–600 ppbv and the detection of limit is 11 ppbv. Moreover, the lifetime and selectivity of the sensor were also investigated. It has the potential to diagnostic volatile organic compounds in human breath. Copyright © 2010 John Wiley & Sons, Ltd
Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum
Authors: Douma Rutger D. , Verheijen Peter J.T. , de Laat Wim T.A.M. , Heijnen Joseph J. , van Gulik Walter M.
Published: February 2010

As is often the case for microbial product formation, the penicillin production rate of Penicillium chrysogenum has been observed to be a function of the growth rate of the organism. The relation between the biomass specific rate of penicillin formation (qp) and growth rate (µ) has been measured under steady state conditions in carbon limited chemostats resulting in a steady state qp(µ) relation. Direct application of such a relation to predict the rate of product formation during dynamic conditions, as they occur, for example, in fed‐batch experiments, leads to errors in the prediction, because qp is not an instantaneous function of the growth rate but rather lags behind because of adaptational and regulatory processes. In this paper a dynamic gene regulation model is presented, in which the specific rate of penicillin production is assumed to be a linear function of the amount of a rate‐limiting enzyme in the penicillin production pathway. Enzyme activity assays were performed and strongly indicated that isopenicillin‐N synthase (IPNS) was the main rate‐limiting enzyme for penicillin‐G biosynthesis in our strain. The developed gene regulation model predicts the expression of this rate limiting enzyme based on glucose repression, fast decay of the mRNA encoding for the enzyme as well as the decay of the enzyme itself. The gene regulation model was combined with a stoichiometric model and appeared to accurately describe the biomass and penicillin concentrations for both chemostat steady‐state as well as the dynamics during chemostat start‐up and fed‐batch cultivation. Biotechnol. Bioeng. 2010;106: 608–618. © 2010 Wiley Periodicals, Inc.
Collapse temperature of solutions important for lyopreservation of living cells at ambient temperature
Authors: Yang Geer , Gilstrap Kyle , Zhang Aili , Xu Lisa X. , He Xiaoming
Published: February 2010

In this study, the collapse temperature was determined using the freeze‐drying microscopy (FDM) method for a variety of cell culture medium‐based solutions (with 0.05–0.8 M trehalose) that are important for long‐term stabilization of living cells in the dry state at ambient temperature (lyopreservation) by freeze‐drying. Being consistent with what has been reported in the literature, the collapse temperature of binary water‐trehalose solutions was found to be similar to the glass transition temperature (T′g ∼ −30°C) of the maximally freeze‐concentrated trehalose solution (∼80 wt% trehalose) during the freezing step of freeze‐drying, regardless of the initial concentration of trehalose. However, the effect of the initial trehalose concentration on the collapse temperature of the cell culture medium‐based trehalose solutions was identified to be much more significant, particularly when the trehalose concentration is less than 0.2 M (the collapse temperature can be as low as −65°C). We also determined that cell density from 1 to 10 million cells/mL and ice seeding at high subzero temperatures (−4 and −7°C) have negligible impact on the solution collapse temperature. However, ice seeding does significantly affect the ice crystal morphology formed during the freezing step and therefore the drying rate. Finally, bulking agents (mannitol) could significantly affect the collapse temperature only when trehalose concentration is low (<0.2 M). However, improving the collapse temperature by using a high concentration of trehalose might be preferred to the addition of bulking agents in the solutions for freeze‐drying of living cells. We further confirmed the applicability of the collapse temperature measured with small‐scale (2 µL) samples using the FDM system to freeze‐drying of large‐scale (1 mL) samples using scanning electron microscopy (SEM) data. Taken together, the results reported in this study should provide useful guidance to the development of optimal freeze‐drying protocols for lyopreservation of living cells at ambient temperature for easy maintenance and convenient wide distribution to end users, which is important to the eventual success of modern cell‐based medicine. Biotechnol. Bioeng. 2010;106: 247–259. © 2010 Wiley Periodicals, Inc.
Evolutionary optimization of peptide substrates for proteases that exhibit rapid hydrolysis kinetics
Authors: Boulware Kevin T. , Jabaiah Abeer , Daugherty Patrick S.
Published: February 2010

Protease cleavage site recognition motifs can be identified using protease substrate discovery methodologies, but typically exhibit non‐optimal specificity and activity. To enable evolutionary optimization of substrate cleavage kinetics, a two‐color cellular library of peptide substrates (CLiPS) methodology was developed. Two‐color CLiPS was applied to identify peptide substrates for the tobacco etch virus (TEV) protease from a random pentapeptide library, which were then optimized by screening of a focused, extended substrate library. Quantitative library screening yielded seven amino acid substrates exhibiting rapid hydrolysis by TEV protease and high sequence similarity to the native seven‐amino‐acid substrate, with a strong consensus of EXLYΦQG. Comparison of hydrolysis rates for a family of closely related substrates indicates that the native seven‐residue TEV substrate co‐evolved with TEV protease to facilitate highly efficient hydrolysis. Consensus motifs revealed by screening enabled database identification of a family of related, putative viral protease substrates. More generally, our results suggest that substrate evolution using CLiPS may be useful for optimizing substrate selectivity and activity to enable the design of more effective protease activity probes, molecular imaging agents, and prodrugs. Biotechnol. Bioeng. 2010; 106: 339–346. © 2010 Wiley Periodicals, Inc.
Health-related quality of life after minimally invasive oesophagectomy
Authors: Parameswaran R , Blazeby J M , Hughes R , Mitchell K , Berrisford R G , Wajed S A
Published: February 2010

Background

Open oesophagectomy has a detrimental impact on health-related quality of life (HRQL), with recovery taking up to a year. Minimally invasive oesophagectomy (MIO) may enable a more rapid recovery of HRQL.

Methods

Clinical outcomes from consecutive patients undergoing MIO for cancer were recorded between April 2005 and April 2007. Patients completed validated questionnaires, European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-OES18, before surgery and at 6 weeks, 3, 6 and 12 months after surgery.

Results

MIO for cancer or high-grade dysplasia was planned in 62 patients, but abandoned in four owing to occult metastatic disease. Resection was completed in the remaining 58, two having partial conversion to open surgery. There was one in-hospital death and 29 patients developed complications. At 1 year, 52 of 58 patients were alive. Questionnaire response rates were high at each time point (overall compliance 84 per cent). Six weeks after MIO, patients reported deterioration in functional aspects of HRQL and more symptoms than at baseline. However, most improved by 3 months and had returned to baseline levels by 6 months. These levels were maintained 1 year after surgery, with 85 per cent of patients recovering in more than 50 per cent of the HRQL domains.

Conclusion

MIO leads to a rapid restoration of HRQL.
Development and validation of a robust LC‐MS‐MS with atmospheric pressure chemical ionization for quantitation of carbazochrome sodium sulfonate in human plasma: application to a pharmacokinetic study
Authors: Song Min , Zhao Hua , Wang Li , Yang Lin , Hang Taijun , Wen Aidong
Published: February 2010

A highly selective and sensitive liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC‐APCI‐MS‐MS) was developed and validated for the quantitation and pharmacokinetic study of carbazochrome sodium sulfonate in human plasma. Protein precipitation with 14% perchloric acid solution was selected for sample preparation, and amiloride hydrochloride was employed as an internal standard. The analytes were separated on a Hypersil ODS‐2 column by a multiple‐step linear gradient elution with a mobile phase consisting of 0.2% formic acid solution and methanol pumped at a flow rate of 1.0 mL/min. The determination was optimized and carried out with positive atmospheric pressure chemical ionization by selective reaction monitoring of the ion of m/z 148, the protonated thermodegraded fragment of the free acidic form of carbazochrome sodium sulfonate selected as the parent, and the ion of m/z 107 as the optimum collision induced dissociation (CID) product. The method was fully validated over a concentration range of 0.5–50 ng/mL, with the lower limit of quantitation of 0.5 ng/mL. The application of the LC‐MS‐MS method was demonstrated for the specific and quantitative analysis of carbazochrome sodium sulfonate in human plasma from a pharmacokinetic study in 24 healthy male Chinese volunteers after a single oral administration of 90 mg carbazochrome sodium sulfonate capsules. Copyright © 2010 John Wiley & Sons, Ltd.