bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of a deep learning algorithm to achieve the low-dose 68Ga-FAPI/the fast-scan PET images: a multicenter study
Authors: Liu Lin , Chen Xingyu , Wan Liwen , Zhang Na , Hu Ruibao , Li Wenbo , Liu Shengping , Zhu Yan , Pang Hua , Liang Dong , Chen Yue , Hu Zhanli
Published: July 2023

Objectives:

Our work aims to study the feasibility of a deep learning algorithm to reduce the 68Ga-FAPI radiotracer injected activity and/or shorten the scanning time and to investigate its effects on image quality and lesion detection ability.

Methods:

The data of 130 patients who underwent 68Ga-FAPI positron emission tomography (PET)/CT in two centers were studied. Predicted full-dose images (DL-22%, DL-28% and DL-33%) were obtained from three groups of low-dose images using a deep learning method and compared with the standard-dose images (raw data). Injection activity for full-dose images was 2.16 ± 0.61 MBq/kg. The quality of the predicted full-dose PET images was subjectively evaluated by two nuclear physicians using a 5-point Likert scale, and objectively evaluated by the peak signal-to-noise ratio, structural similarity index and root mean square error. The maximum standardized uptake value and the mean standardized uptake value (SUVmean) were used to quantitatively analyze the four volumes of interest (the brain, liver, left lung and right lung) and all lesions, and the lesion detection rate was calculated.

Results:

Data showed that the DL-33% images of the two test data sets met the clinical diagnosis requirements, and the overall lesion detection rate of the two centers reached 95.9%.

Conclusion:

Through deep learning, we demonstrated that reducing the 68Ga-FAPI injected activity and/or shortening the scanning time in PET/CT imaging was feasible. In addition, 68Ga-FAPI dose as low as 33% of the standard dose maintained acceptable image quality.

Advances in knowledge:

This is the first study of low-dose 68Ga-FAPI PET images from two centers using a deep learning algorithm.
Advances in the study of biomarkers related to bone metastasis in breast cancer
Authors: Xu Dongcheng , Tang Mingxing
Published: July 2023

Breast cancer is by far the most common malignancy in females. And bone is the most common site of distant metastasis in breast cancer, accounting for about 65 to 75% of all metastatic breast cancer patients.1,2Bone metastasis is an important factor affecting the prognosis of breast cancer. When patients have early-stage breast cancer without metastasis, their 5-year survival rate is as high as 90%, and once metastasis occurs, their 5-year survival rate will drop to 10%.3 Bone radionuclide imaging (ECT), X-ray, CT scan, MRI and other imaging tests to diagnose breast cancer bone metastasis are commonly used in clinical, It is currently believed that breast cancer bone metastasis is a multistep process: first, breast cancer cells need to acquire invasive and metastatic properties; breast cancer cells enter the blood circulation and migrate from blood breast cancer cells enter the blood circulation and migrate from blood vessels to bone tissue in a targeted manner; breast cancer cells adhere and remain in bone tissue and colonise it; and finally, it leads to bone destruction.4 Several key molecules are involved in breast cancer bone metastasis, and serum biomarkers are generally able to detect pathological changes earlier Several key molecules are involved in breast cancer bone metastasis, and serum biomarkers are generally able to detect pathological changes earlier than imaging.5 This review describes the progress of serum biomarkers for breast cancer bone metastasis.
Diffusion-weighted and diffusion kurtosis imaging analysis of microstructural differences in clear cell renal cell carcinoma: a comparative study
Authors: Zou Jinzhao , Ye Jing , Zhu Wenrong , Wu Jingtao , Chen Wenxin , Chen Rui , Zhu Qingqiang
Published: July 2023

Objective:

To quantitatively compare the diagnostic values of conventional diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) analysis of microstructural differences for clear cell renal cell carcinoma (CRCC).

Methods:

A total of 108 patients with pathologically confirmed CRCC, including 38 Grade I, 37 Grade II, 18 Grade III and 15 Grade IV, were enrolled and divided into groups according to tumor grade [low grade (Ⅰ+Ⅱ, n = 75) and high grade (Ⅲ+Ⅳ, n = 33)]. Apparent diffusion coefficient (ADC), mean diffusivity (MD), mean kurtosis (MK), kurtosis anisotropy (KA) and radial kurtosis (RK) were performed.

Results:

Both the ADC (r = −0.803) and MD (−0.867) values showed a negative correlation with tumor grading (p < 0.05) and MK (r = 0.812), KA (0.816) and RK (0.853) values a positive correlation with tumor grading (p < 0.05). Mean FA values showed no significant differences among CRCC grades (p > 0.05). ROC curve analyses showed that MD values had the highest diagnostic efficacy in differentiating low/high and Ⅱ/Ⅲ tumor grading. MD values gave AUC: 0.937 (0.896); sensitivity: 92.0% (86.5%); specificity: 78.8% (77.8%) and accuracy: 90.7% (87.3%). ADC performed worse than MD, MK, KA or RK (all p < 0.05) during pair-wise comparisons of ROC curves to show diagnostic efficacy.

Conclusion:

DKI analysis performs better than ADC in differentiating CRCC grading.

Advances in knowledge:

Both the ADC and MD values correlated negatively with CRCC grading.

The MK, KA and RK values correlated positively with CRCC grading.

MD values had the highest diagnostic efficacy in differentiating low/high and Ⅱ/Ⅲ CRCC grading.
Radiomics and Ki-67 index predict survival in clear cell renal cell carcinoma
Authors: Zhang Tong , Ming Ying , Xu Jingxu , Jin Ke , Huang Chencui , Duan Mingguang , Li Kaiguo , Liu Yuanwei , Lv Yonghui , Zhang Jie , Huang Zhaoqin
Published: July 2023

Objective:

To develop and validate predictive models based on Ki-67 index, radiomics, and Ki-67 index combined with radiomics for survival analysis of patients with clear cell renal cell carcinoma.

Methods:

This study enrolled 148 patients who were pathologically diagnosed as ccRCC between March 2010 and December 2018 at our institute. All tissue sections were collected and immunohistochemical staining was performed to calculate Ki-67 index. All patients were randomly divided into the training and validation sets in a 7:3 ratio. Regions of interests (ROIs) were segmented manually. Radiomics features were selected from ROIs in unenhanced, corticomedullary, and nephrographic phases. Multivariate Cox models based on the Ki-67 index and radiomics and univariate Cox models based on the Ki-67 index or radiomics alone were built; the predictive power was evaluated by the concordance (C)-index, integrated area under the curve, and integrated Brier Score.

Results:

Five features were selected to establish the prediction models of radiomics and combined model. The C-indexes of Ki-67 index model, radiomics model, and combined model were 0.741, 0.718, and 0.782 for disease-free survival (DFS); 0.941, 0.866, and 0.963 for overall survival, respectively. The predictive power of combined model was the best in both training and validation sets.

Conclusion:

The survival prediction performance of combined model was better than Ki-67 model or radiomics model. The combined model is a promising tool for predicting the prognosis of patients with ccRCC in the future.

Advances in knowledge:

Both Ki-67 and radiomics have showed giant potential in prognosis prediction. There are few studies to investigate the predictive ability of Ki-67 combined with radiomics. This study intended to build a combined model and provide a reliable prognosis for ccRCC in clinical practice.
The value of gallium-68 prostate-specific membrane antigen PET/CT and 2-[18F]fluoro-2-deoxy-D-glucose PET/CT in the detection of thyroid cancer lesions: a prospective head-to-head comparison
Authors: Shi Yangrui , Feng Yuyue , Xu Lu , Li Wenbo , Guan Lili , Zuo Rui , Liu Shuang , Pang Hua , Wang Zhengjie
Published: July 2023

Objective

Thyroid cancer is increasing in incidence. Prostate-specific membrane antigen (PSMA) targeted radionuclide imaging and treatment demonstrated remarkable value in prostate cancer patients. Studies have shown that PSMA is also expressed in thyroid cancer. Our purpose is to evaluate the clinical usefulness of [68Ga]Ga-PSMA-11 PET/CT for the diagnosis of thyroid cancer.

Methods

We enrolled 23 DTC and 17 RAIR-DTC patients prospectively. All patients underwent [68Ga]Ga-PSMA-11 PET/CT and 2-[18F]FDG PET/CT. PSMA expression was determined by immunohistochemistry on histological samples of lymphatic metastasis of 12 patients. We compared the detection rates and semi-quantitative parameters between [68Ga]Ga-PSMA-11PET/CT and 2-[18F]FDG PET/CT.

Results

A total of 72 lesions were detected. Detection rates of DTC and RAIR-DTC by [68Ga]Ga-PSMA-11 PET/CT were lower than those by 2-[18F]FDG PET/CT (60.00% vs. 90.00%, P = .004; 59.38% vs. 96.88%). Compared with DTC, RAIR-DTC had higher semi-quantitative parameters of 2-[18F]FDG PET/CT. There was no significant difference in semi-quantitative parameters of [68Ga]Ga-PSMA-11 PET/CT between DTC and RAIR-DTC. Immunohistochemistry showed a significantly higher PSMA expression for RAIR-DTC than for DTC. However, there was no significant correlation between PSMA expression and SUVmax on 68Ga-PSMA [68Ga]Ga-PSMA-11 PET/CT.

Conclusions

[68Ga]Ga-PSMA-11 PET/CT can detect thyroid cancer metastases but its detection rate was lower than that of 2-[18F]FDG PET/CT. There was a difference in PSMA expression levels between DTC and RAIR-DTC, but the difference was not reflected on [68Ga]Ga-PSMA-11 PET/CT.

Advances in knowledge

[68Ga]Ga-PSMA-11 PET/CT has potential value in the diagnosis of thyroid cancer. [68Ga]Ga-PSMA-11 PET/CT could screen out patients who may benefit from PSMA-targeted radionuclide therapy.
Temporomandibular joint dysfunction syndrome – a therapeutic approach
Authors: Bochiș Călin Florin , Pop Manuela Simona , Bochiș Sergiu Alin , Botea Mihai Octavian , Pop Mircea Gheorghe , Nistor-Cseppento Carmen Delia , Bungău Alexa Florina , Dogaru Bombonica Gabriela , Tarce Alexandra Georgiana
Published: July 2023

1) Background: Temporomandibular joint (TMJ) is responsible for vital functions like mastication, swallowing, and suction reflex and other relational functions, like talking and phonation. The etiology of temporomandibular joint disorders is multifactorial and involves subjective and objective clinical symptomatology. (2) Methods: The therapy is complex and encompasses a series of methods that interconnects various medical spe-cialties. Bad habits and parafunction are risk factors that may initiate and exacerbate a temporomandibular joint pathology. This prospective study aimed to show the positive impact of correct multidisciplinary therapy on the complex of TMJ disorders - pain and bad oral behaviors. The therapy methods used in this study were: medical, prosthetic, or-thodontic, surgical, and physiotherapy (PKT). (3) Results: The data obtained showed good results if the oral habits and TMJ disorders are treated correctly and simultaneous-ly. (4) Conclusions: All therapeutical approaches addressed in this study had beneficial effects on the recovery of the temporomandibular joint.
Keywords: therapeutic approach; temporomandibular joint; TMJ disorders; pain; multidisci-plinary therapy
ASSESSMENT OF MUSCULOSKELETAL PAIN IN MEDICAL REHABILITATION OF POST-COVID-19 PATIENTS
Authors: Tăbîrță Alisa , Bulai Marina , Chihai Victoria , Pascal Oleg
Published: July 2023

Remaining phenomena presented by people who endured COVID -19 at various times after the acute phase of the disea-se, remain the objectives of the medical and social approaches. Musculoskeletal pain is increasingly reported by pati-ents as one of the persistent symptoms in post-COVID-19 syndrome. The purpose of the study was the qualitative and quantitative assessment of musculoskeletal pain post _COVID 19 in the process of in-hospital medical rehabilitation.
Methods: A group of 124 people who suffered SARS-Cov-2 infection were analyzed and underwent rehabilitation treat-ment with physiotherapy, halotherapy and electrotherapy sessions in the specialized “Post COVID rehabilitation” ward during a period of 14 days. For the analysis of the pain phenomenon, 103 people who presented musculoskeletal pain, before and after treatment were assessed by the Nordic Musculoskeletal Questionnaire, pain intensity by VAS scale and intensity of fatigue syndrome.
Results. Musculoskeletal pain was present in 84.3% of cases among persons admitted for rehabilitation treatment. Re-habilitation programs applied under inpatient conditions increased the rate of people with moderate and mild pain by 6.8% and decreased the rate of those with severe pain by 13.6% (p< 0.05), assessed by the Nordic Musculoskeletal Ques-tionnaire. The proportion of patients with severe pain, assessed by the VAS scale, decreased by 13.8% at discharge from the hospital.
Conclusion. In-hospital medical rehabilitation programs applied to people with musculoskeletal pain post -COVID 19 had a beneficial effect by decreasing the number of painful areas and pain intensity.
Keywords: post-COVID medical rehabilitation, musculoskeletal pain
The Impact of Technology on Improving the Learning Process in Physical Education Lessons for Medically-Exempt Pupils
Authors: Pârvu Carmen , Ungurean Bogdan Constantin , Zamfir Cristina Gabriela , Khamraeva Zukhro Bahadirovna , Alistar Daniel Gabriel
Published: July 2023

Background and Study Aim. The focus of our attention lies on the medically exempt students, who more often than not take part in physical education (P.E.) classes as spectators, without any tasks to complete in accord with the collective work of their classmates or the objective of the lesson. The purpose of the present research is to develop and implement the application Info-Scutit-Sport in the P.E. lesson to the purpose of teaching and assessing medically-exempt students, who are present, but do not take part in the lesson. Material and Methods. The present paper emphasises the usefulness of the Info-Scutit-Efort [Info-Exempt-Effort] application aimed at the active and mindful inclusion of 55 students (aged=11.29±1.84), who have a medical exemption (58.2% total and 42.8% partial) in the P.E. lesson. The appli-cation, in an improved form, comprises the entire content of the curriculum of physical edu-cation in secondary school, transformed into 2080 questions with three answer variants, with 1500 processed images, that may be accessed with the teacher’s accord, on the stu-dent’s own phone. The assessment obtained by means of the application after the working session may provide the student with a mark for the information taught before, if he accesses topics from the previous lessons, or a mark for the current assessment in order to test the ac-tive and mindful participation in the lesson which is being taught. Conclusions. The study utilized multiple statistical tests to establish a relationship between platform access time and student performance. The results of the tests demonstrated that platform use time has a significant impact on student performance, with longer platform access time leading to hi-gher marks. The study concluded that the proposed model is significant, as it identifies plat-form access time as a crucial factor in determining student performance. Moreover, the study found that even small increases in platform access time can lead to significant impro-vements in student performance, with an increase of one unit resulting in a 0.54% increase in marks.

Keywords: : medically-exempt students, physical education (P.E.), quiz application, health, learning, innovative teaching methods
Clinical Applications and Biological Effects of Sauna Bathing – a Narrative Review
Authors: Dogaru Gabriela , Stănescu Ioana , Szakacz Dora Violeta , Ciubean Alina Deniza
Published: July 2023

Background: Regular sauna exposure has been shown to positively influence clinical symptoms in various pathologies. The purpose of this review is to present the evidence accumulated so far in order to evaluate the efficiency, effects, benefits and risks of sauna therapy in the field of various pathologies that require medical rehabilitation. Methods: A literature search was conducted on Publons and PubMed databases from January 2000 onwards. The studies selected for this review included research in humans undergoing repeated sauna sessions with at least one reported health outcome. Results: Constant application of sauna therapy has visible effecta on improving cardiac activity, endothelial function, myocardial perfusion, ventricular arrhythmia. Sauna treatment is a safe proce-dure for patients with cardiovascular, respiratory, musculo-skeletal pathologies, with no notable side-effects. Conclusions: Sauna therapy has proved its effectiveness in medical rehabilitation treatment starting from the musculoskeletal system and skin to the nervous system. In addition, it brings a significant improvement in the quality of life of patients.
Keywords: sauna bathing; dry sauna; regular sauna exposure; clinical applications sauna; bio-logical effects sauna; quality of life
Medicinal effects of microbubble bath on atopic eczema and psoriasis vulgaris
Authors: Och Frantisek , Mankovecky Lubomir , Saskova Dana , Kulaviak Lukas
Published: July 2023

The incidence of atopic eczema in the population reaches generally up to 25%. Skin dis-eases such as Atopic eczema and Psoriasis vulgaris are a worldwide problem. Use of topi-cal corticosteroids is the first-line treatment for atopic dermatitis flare-ups. Last individual case studies led to the hypothesis: Baths with microbubbles in tap water can significantly support the treatment of skin diseases. Microbubbles penetrate deep into the skin pores. Micro implosions occur on the pore walls, which mechanically affect nerve endings and vascular microcapillaries. In addition, due to the implosion of microbubbles, the mechan-ical effect leads to an increased release and flushing of substances contained in the skin pores. A total of 30 patients were selected for the study, of which 15 were included in the Study Group and 15 in the Control Group. The effects were monitored on the objectively evaluable dermatological calculators PASI, EASI, SCORAD, and DLQI Score, Quality of life, and Number and condition of foci. The project responded to the hypothesis that mi-crobubbles in the water phase, produced by special generators, in the size range of 1-100 µm, may in the future become a fundamental innovation in balneological treatment in the form of new treatment procedures.
Keywords: balneology, microbubbles, preclinical analysis, atopic eczema, psoriasis, therapeutic bath
New methodological aspects in rehabilitation after proximal humerus fracture
Authors: Burcea Claudia-Camelia , Bobu Vasile , Ferechide Dumitru , Neagoe Ioana Cristina , Lupușoru Gabriela Elena , Sporea Corina , Lupușoru Mircea Ovidiu Denis
Published: July 2023

Proximal humerus fracture ranks third in the elderly after femoral neck fractures and distal radius fractures, and seventh in adults, and the risk of occurrence is related to advancing age. In this study we aimed to analyze the efficacy of a 24-weeks physical therapy programme based on a particular methodology consisting of the reprogramming of the specific proprioceptive neuromuscular facil-itation techniques added to the classical physical therapy and by introducing modern interactive therapies and technologies: Capacitive Resistive Electric Transference, Instrument Assisted Soft Tissue Mobilization, kinesiological tapes and PRAMA system, compared with classical physical therapy. Our study included 26 patients, aged between 18 and 55 years, with proximal humerus fracture, who complete the 24-weeks rehabilitation programme. We assessed pain, shoulder range of motion, muscle strength and the ability to perform activities of daily living. The statistical analysis was performed using IBM SPSS and Excel 2021. The results showed statistically significant im-provement in all shoulder motion, increased muscle strength, decreased pain, and a better ability to perform daily activities. The physical therapy programme based on the proposed particular methodology has proven to be more effective than classical physical therapy, both regarding the improvement of the movement parameters compared to the physiological values, as well as the symmetry of both shoulders.
Keywords: proximal humerus fracture; rehabilitation; range of motion; muscle strength; pain; activities of daily living
Rehabilitation and clinical evolution aspects in a case of Osteoid Osteoma
Authors: Ilut Silvina , Dogaru Gabriela , Muresan Oana , Muresanu Dafin F.
Published: July 2023

Introduction. Osteoid osteoma represents about 3% of all primary bone tumors and 11% of all benign bone tumors. Data from the literature suggest that a neuromuscular rehabilita-tion program after osteoid osteoma surgery is very beneficial and improves the general quality of life.
Material and methods. A 30-year-old male patient with intermittent right shoulder pain radiating to the right hand, and recurrent myalgias in the past year presented to our neuro-logical department. The neurological examination highlighted limitation of the abduction of the right upper limb. The paraclinical investigations included plain radiography of the right upper limb and electroneurography, which were normal, and native cervical MRI which revealed discrete C5 disc overflow, without visible signs of compression. The patient presented limited initial response to NSAIDs, so his treatment was changed to corticoster-oid therapy. Further, the patient was guided to undergo a rheumatological examination where a musculoskeletal ultrasound was performed, showing no any specific modifica-tion. Additionally, we indicated a native right shoulder MRI, which revealed a signal mod-ification of the proximal humeral diaphysis. We further indicated an MRI scan with con-trast of the upper right limb, which revealed a nidus at the top one-third of the humerus. Additionally, a CT scan with contrast of the same region displayed images that were high-ly suggestive of osteoma. The patient was referred to the orthopedics department, where a complete resection of the tumor was performed, and the pathology report confirmed the fi-nal diagnosis of osteoid osteoma.
Conclusions. Recovery after osteoid osteoma surgery is more beneficial if the neuromuscu-lar rehabilitation program, that has an important role in increasing muscle strength, is combined with orthopedic devices and pain medication.
Keywords: bone tumor, osteoid osteoma, upper limb, imaging changes, differential diag-nosis difficulty
The impact of the biodex 4 pro system dynamometer in the rehabilitation of ankle sprain in youth football players
Authors: Xhardo Kristo , Iacob George Sebastian , Cotrobaș-Dascălu Vlad-Theodor , Cordun Mariana , Stoica Marius , Pelin Florin , Baltag Oana Maria , Predescu Corina , Gherghel Carmen , Bratu Mircea , Iordan Daniel Andrei , Onu Ilie
Published: July 2023

Background: The purpose of this study was to identify impact differences in the rehabilitation the second-degree ankle sprain, more specifically the restoration of agonist-antagonist muscle balance, static and dynamic balance, and motor control in junior soccer players will have a different impact on patients who perform the recovery program with the help of Biodex 4 Pro and myofascial therapies compared to those who perform physical therapy using classical methods. (2) Methods: the study included 22 subjects divided into two equal groups in accordance with the agreement to practice modern therapies (MT) and kinesiotherapy (KT): the experimental group that performed the myofascial therapies and exercises with Biodex 4 pro and the control group that performed the KT. The parties' evaluations included: the Biodex 4 Pro for a range of motion assessment and the PodoSmart device for gait assessment. (3) Results: analysis identifies significant improvements for the subjects in the experimental group, respectively for the subjects in the control group, as follows: after completing the therapeutic plan for four weeks, the subjects gained 35.8° of flexion and 36.4° of extension compared to the initial results. In the PodoSmart gait analysis, the experimental group progressed between tests by 14.8% for the foot symmetry parameter, which was 3.8% more than in the control group, whose symmetry progress between tests was 11%. (4) Conclusion: the combined therapeutic plan containing Biodex technology and myofascial therapies is a current effective option in the rehabilitation of athletes.
Keywords: ankle sprain, rehabilitation, Biodex dynamometer, myofascial
Variants of Amyotrophic lateral sclerosis and rehabilitation: an overview
Authors: Iluț Silvina , Stan Adina , Rahovan Imelda , Hapca Elian , Zmaranda Ioana , Strilciuc Stefan , Muresanu Dafin F.
Published: July 2023

Amyotrophic lateral sclerosis (ALS) represents a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord leading to the impairment of volun-tary muscle control and eventually death. It accounts for about 80%-90% of all motor neu-ron diseases, and is characterized by a marked variability in terms of clinical forms, gene-tics, survival rate and diagnostic particularities. A diagnosis of ALS or one of the variants comes with a great burden for the patient and patient’s family because of the high morbidi-ty and mortality rate of this disorder. As a consequence, it is mandatory to optimize the ac-curacy of the diagnostic process of ALS spectrum for providing the best clinical manage-ment and quality of life for patients and avoiding diagnostic mistakes. Our review focuses on the general and particular aspects of ALS and its variants in an effort to improve the process of diagnosis, therapy and exclusion of mimics of this group of diseases and to pro-vide the latest findings in this field.

Keywords: amyotrophic lateral sclerosis, rehabilitation in ALS, flail leg, flail arm, progres-sive muscular atrophy.
The effect of the gel with tricolor violet extract on the activity of the antioxidant defense system in rats with a model of pаrodontitis
Authors: Novytska Iryna , Gorbatovska Natalya , Nikolaeva Ganna , Tretyakova Olena , Gushcha Sergey
Published: July 2023

The authors investigated the antioxidant properties of the gel with tricolor violet extract when used in rats with an experimental pаrodontitis model. To simulate periodontal pa-thology, white laboratory rats were given a solution of ethylenediaminetetraacetic acid (2%) daily with drinking water and three times a week; the drug "Warfarin Orion" was administered per os for 30 days. Animals were randomly divided into four equal groups of 10 each. Group 1 - intact rats; group 2 - rats with a model of pаrodontitis; group 3 - rats with a model and applications on the mucous membrane of the alveolar process gel "Pla-cebo". Group 4 - rats with a pаrodontitis model and applications on the mucous mem-brane of the alveolar process of the gel with the violet extract. In periodontal tissues and blood serum, we studied the level of inflammation markers - malondialdehyde (MDA) and diene conjugation. The state of the antioxidant defense system (AODS) was also assessed by the activity of glutathione peroxidase (GP), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G-6-PD), superoxide dismutase (SOD), and catalase. The pаro-dontitis model in rats of the 2nd group was characterized by the development of inflam-matory processes in periodontal tissues and blood, which is confirmed by changes in the pro- and antioxidant protection system. In rats of the 4th group, the content of MDA was restored in periodontal tissues. The state of the AOP system was normalized (decrease in the activity of SOD and catalase to the values of group 1), the tension in the glutathione-antioxidant defense system disappeared (the activity of GP decreased, and the activity of GR and G-6-PDH increased to the level control). In the blood serum, the content of MDA significantly reduced, and the level of DC remained higher than in group 1.In contrast, sta-bilization of the activity of marker enzymes of glutathione-antioxidant protection in blood serum (GP, GR, G-6-PDH) was noted with significant activation of the activity of SOD and catalase, with stabilization of SOD and catalase.
Conclusion. The periodontal protective effectiveness of the gel with tricolor violet was es-tablished, as evidenced by the restoration of the state of protective antioxidant systems and the inhibition of lipid peroxidation processes both directly in the periodontal tissues and at the system level.
Keywords: experimental pаrodontitis, lipid peroxidation, antioxidant protection, gel with tricolor violet.
Haloaerosoltherapy and complex recovery treatment based on it as methods of physical rehabilitation for patients with chronic obstructive pulmonary disease
Authors: Lemko Olha , Reshetar Diana , Lukashchuk Svitlana , Vantiukh Nataliia
Published: July 2023

Rehabilitation programs for patients with COPD are based on physical exercises usage, but accounting low tolerance to physical activity, this is not always a real task. The aim is to study the effect of haloaerosoltherapy (HAT) and complex rehabilitation treatment based on it on functional recovery of COPD patients. Materials and methods: 133 patients with COPD (GOLD II-III) beyond acute period were examined. Bronchial obstruction, intensity of clinical manifestations, disturbances of cardiovascular system were investigated. The 6-minute walk test was conducted. Results: Before treatment, it has been shown that exercise tolerance significantly depended on severity of bronchial obstruction, intensity of clinical manifestations and degree of cardiovascular risk. Treatment was carried out according to three treatment complexes (TC). TC-1 was based on HAT usage with certain concentration and dispersion of aerosol, 18-20 seances per course. In TC-2, singlet oxygen therapy was included, in TC-3 mineral water was administered as drinking use and inhalation. After course of treatment, walking distance covered in 6 minutes has been increased in patients of all groups. When using complex treatment, these changes were more pronounced. Con-clusions: HAT with appropriate dispersion and concentration of haloaerosol promotes in-creasing tolerance to physical activity and may be used as a stage of physical rehabilitation with possible subsequent therapeutic physical exercises. Notably pronounced positive dy-namics of studied data was noted in COPD patients convalescents after COVID-19.
Key words: COPD, physical rehabilitation, haloaerosoltherapy, COVID-19 convalescents.
The influence of the specificity of sports specializations on the values of muscle power for female university students
Authors: Mocanu George Danut , Murariu Gabriel
Published: July 2023

Background: Explosive strength or muscle power plays a decisive role in the motor performance of all athletes. Purpose: Analysis of muscle strength variations for female students of the Faculty of Physical Education and Sport/undergraduate level, according to sports specializations. Mate-rial and method: The study included 77 women (age = 20.48 ± 1.37 years, weight = 58.79 ± 8.92 kg, height = 166.24 ± 7.13 cm), divided into 3 evaluation subgroups (Non-athletes/NA = 40 cases, Team sports games/TSG = 17 cases and IS/Individual sports = 20 cases). Explosive strength rating was based on 7 lower body tests and 6 upper body tests. Manova parametric techniques were applied. Results: The analysis of variance indicates significant differences between the 3 defined groups, the F values correspond to thresholds p <0.05. Pairwise analysis highlights the statistical superiority of TSG and IS groups compared to NA. We noted better values of the TSG group of women in all upper body strength assessment tests, but these differences are not significant (p>0.05). Top performance values are dominated by sprinters and volleyball players for the low-er body, respectively by handball, volleyball and karate players for the upper body, as-pects confirmed by the studied sources. Conclusion: We did not identify significant differences be-tween the groups of athletes (TSG and IS), and the top values according to sports specialization reinforce the results of other similar studies, the specific effort obviously infusing the perfor-mance in the muscle strength tests.

Keywords: specific effort, muscle power, rapid contractions, adaptation, university students
Cellular and Molecular Homeostatic Microenvironmental imbalances in Osteoarthritis and Rheumatoid Arthritis
Authors: Munteanu Constantin , Onose Gelu , Turnea Marius-Alexandru , Rotariu Mariana
Published: July 2023

Human movement is a complex and multifactorial process due to the interaction between the body and the environment. Movement is the result of activities of all the structures that make up a joint (i.e., ligaments, tendons, muscles, fascicles, blood vessels, nerves, etc.) and of the control actions of the nervous system on them. Therefore, many pathological conditions can affect the Neu-ro-Myo-Arthro-Kinetic System (NMAK). Osteoarthritis (OA) is the degenerative form of arthritis with a high incidence and a pro-longed course that affects articular and periarticular tissues such as articular cartilage, subchondral bone, and synovium, a degen-erative consequence. Instead, Rheumatoid arthritis (RA) is an immune-mediated synovial disease caused by a complex interaction between genetic and environmental factors. This review aims to compare Osteoar-thritis (OA) and Rheumatoid Arthritis (RA) in terms of pathogenesis and microenvironment and determine the main changes in a joint microenvironment regarding immunological defense elements and bioenergetics which can explain the pathological development with new thera-peutical opportunities.
Keywords: Osteoarthritis (OA); Rheumatoid arthritis (RA); Homeostatic imbalances; Microenvironment
Current data regarding homeostasis of tissues oxygenation in pathophysiological and therapeutic circumstances
Authors: Munteanu Constantin , Călin Mihaela Antonina , Manea Dragoș , Popescu Cristina , Iliescu Mădălina , Ionescu Elena Valentina , Stanciu Liliana , Minea Mihaela , Oprea Carmen , Oprea Doinița , Rotariu Mariana , Onose Gelu
Published: July 2023

Oxygen is essential for cellular respiration and energy production. Tissue oxygenation refers to delivering oxygen to cells throughout the body. Microcirculation brings blood through small sanguine vessels to maintain the cells' supply of nutrients and oxygen. Optimal tissue oxygenation and microcirculation are essential for maintaining healthy tissue. Conversely, poor oxygenation can cause tissue damage, impair wound healing, and increase infection risk. Several factors can affect tissue oxygenation and microcirculation, including age, lifestyle factors (such as smoking and stress), and underlying medical conditions (such as diabetes and high blood pressure). To improve tissue oxygenation and microcirculation, individuals can engage in healthy lifestyle habits such as regular exercise, healthy eating, stress management, and avoiding smoking. Tissue oxygenation can also be looked therapeutic, given that topical and cosmetic treatments such as massage, pelotherapy, hydrotherapy, moisturizers, and certain skin care products can help pro-mote healthy microcirculation at the somatic level. In the scientific literature, the focus is on hypoxia rather than tissue oxygenation. This article proposes a paradigm shift and emphasizes the homeostatic importance of microcirculation and tissue oxygenation in pathophysiological and therapeutic circumstances. The systematic review of the data from the last 2 years (2021-2022) and the meta-analysis performed on tissue oxygenation will contribute to the practical approach to the pathology circumscribed to tissue oxygenation.
Keywords: Tissue oxygenation; Hypoxia; Microcirculation; Homeostasis; Microenvironment
An Overview of Basic Concepts of Finite Element Analysis and Its Applications in Orthodontics
Authors: Rastegari Shafagh , Hosseini Seyed Majid , Hasani Mojtaba , Jamilian Abdolreza
Published: July 2023

Purpose: The aim of this article is to acquaint the readers with the aims and goals of the finite element method and how to use it in dentistry and especially in orthodontics.

Methods: The finite element method (FEM) has shown to be a beneficial research tool that has assisted scientists in various analyses such as stress-strain, heat transfer, dynamic, collision, and deformation analyses. The FEM is responsible for predicting the behavior of objects under different working conditions. It is a computational procedure to measure the stress in an element, which performs a model solution to solve a problem; the FEM subdivides a large system into smaller, simpler parts called finite elements. This is achieved by a particular space discretization in the space dimensions, which is implemented by the construction of a mesh of the object. The technique of FEA lies in the development of a suitable mesh arrangement.

Conclusions: The FEM can be effective in understanding the behavior of teeth, both jaws, craniofacial structure, and other hard tissue structures of humans under various working conditions, as the technique allows for evaluating tooth movement and the stress distribution within the surrounding alveolar bone, the periodontal ligament (PDL). This technique is exceptionally valuable for evaluating mechanical aspects of biomaterials and human tissues that can hardly be measured in vivo. This review article presents the FEM, its methodology, and its application in the orthodontic domain.
July 2023 Medical Image of the Month: Primary Tracheal Lymphoma
Authors:   Department of Radiology, Mayo Clinic Arizona, Scottsdale, AZ USA, Jokerst Clinton , Stib Matthew , Rojas Carlos , Panse Prasad , Cummings Kris , Jensen Eric , Gotway Michael
Published: July 2023

No abstract available. Article truncated after 150 words. A 72-year-old woman was referred to our practice from an outside hospital with a history of tracheal mass with impending airway compromise. She originally presented with several days of dyspnea, stridor, and an increasingly muffled voice. She also provided a history of severe shortness of breath, but only when eating. Interestingly, she had no trouble swallowing. CXR findings at the outside hospital (Figure 1) prompted a CT (Figure 2A), which further prompted transfer of patient to our facility. The patient had a history of hypertension, hyperlipidemia, type 2 diabetes and obstructive sleep apnea. Her past surgical history included C-section and hysterectomy. The patient was a never-smoker with no significant drinking or drug usage history. The patient had no recent travel or exposure history. Review of symptoms otherwise negative. Although the patient had no formal diagnosis of asthma, she was on Mometasone/formoterol, 2 puffs bid and also had an albuterol rescue …
Transrapid – eine Chance!
Authors: Masuhr Joachim
Published: July 2023

In Auseinandersetzung mit der Stellungnahme des Wissenschaftlichen Beirats beim Bundesverkehrsminister zu Transrapid und mit der grundsätzlichen Ablehnung durch Landschafts- und Umweltschutz wird herausgestellt, daß entscheidende Vorteile des Systems bisher in der öffentlichen Diskussion wenig zur Geltung gekommen sind. So ist auch bei der Beurteilung der technisch-wirtschaftlichen Einsatzreife durch den Wissenschaftlichen Beirat unverkennbar, daß Vorteile des Transrapid-Systems nicht mit dem gleichen Gewicht vertreten werden wie die des Rad/Schiene-Systems. Mit erstaunlicher Nachsicht werden Rad/Schiene Entwicklungsmöglichkeiten eingeräumt, die Transrapid nicht zugebilligt werden. Es zeigt sich aber, daß Transrapid bei gleichem Beurteilungsmaßstab erheblich mehr Vorteile eingeräumt werden müßten.Der von Landschafts- und Umweltschutz grundsätzlich verfochtenen Ablehnung werden die zumeist verschwiegenen Vorteile gegenübergestellt. Flächenbeanspruchung und Naturverträglichkeit sind nämlich im Vergleich zu herkömmlichen Verkehrssystemen erheblich günstiger. Von Verkehrswissenschaftlern wird auf lange Sicht der Magnetbahn durchaus die Chance eingeräumt, in Europa als Trägersystem des spurgeführten Verkehrs auf großen Achsen zu verkehren. Hieran anknüpfend werden aus raumordnerischer Sicht Anregungen für Netzentwicklungen gegeben, ausgehend von einer ersten Anwenderstrecke Berlin-Hamburg. Solche anscheinend sehr zeitfernen Ausblicke schmelzen hinsichtlich der Planungszeiten so zusammen, daß als Schlußfolgerung die Aufforderung an Politik, Verwaltung und Wirtschaftsunternehmen ergeht, keine weiteren Verzögerungen mehr für die Realisierung einer ersten Strecke zu dulden.
Raum- und siedlungsstrukturelle Probleme und Konzepte für die peripheren ländlichen Gebiete im Lande Brandenburg
Authors: Diller Christian , Hübler Karl-Hermann
Published: July 2023

Nach einer Bezeichnung der peripheren Gebiete Brandenburgs werden in dem Beitrag die Ausgangssituation und die Entwicklungsperspektiven dieser Regionen skizziert. Diese Entwicklungsmöglichkeiten werden vor dem Hintergrund der Standortsituation, der Potentiale und der Abwanderungen skeptisch eingeschätzt. Sodann werden zwei in Brandenburg favorisierte Entwicklungsmodelle – zentrale Orte und Entwicklungszentren – vorgestellt und kritisch beleuchtet. Schließlich wird im Schlußteil des Beitrags für eine stärkere regionale Betrachtungsweise und für eine Neudefinition der Norm „der Schaffung von gleichwertigen Lebensbedingungen in allen Teilräumen“ plädiert.
Citraan dan Majas dalam Lirik Lagu "Harehare Ya" Karya Maigo Hanyuu Kajian Stilistika
Authors: Hastuti Nur , Ayuni Sri Rezeki
Published: July 2023

Song lyrics are part of the music. Music is made up of rhythm, time signature, harmony and melody. Song lyrics act as one of the elements in the main melody in a music. This study aims to describe the images and figure of speech in the lyrics of the song harehare ya by Maigo Hanyuu. The method used in this study uses stylistic studies as an analytical tool. The data used in this study are the lyrics of the song harehare ya by Maigo Hanyuu. The theory used is Hermintoyo's imagery theory and Seto Kenichi's figure of speech theory. Based on data analysis, it can be concluded that in the lyrics of the song harehare ya by Maigo Hanyuu, imagery and figurative language are found. There are four imagery in the lyrics of this song, namely, imagery of sight, hearing, movement, and feeling. In the lyrics of this song, there are also many figurative language of affirmation dominated by repetition. There are nine repetition figures of speech in the lyrics of this song, and rhetorical figures of speech in the lyrics of this song are two.Keywords: Figure of speech,  harehare ya, imagery,  song lyrics
Akutagawa Ryunosuke's Repertoire in the Short Story "Rashomon"
Authors: Rahman Aulia , Nesa Fakhria
Published: July 2023

An author's creative process cannot be separated from the storehouse of knowledge obtained from different results of reading, hearing, or observing of the events around him. This store of knowledge, when juxtaposed with the concept introduced by Wolfgang Iser in his book The Act of Reading: A Theory of Aesthetic Response (1987), can be called a Repertoire. Shortly, repertoire can be understood as the basis for creating a work, as the background to make the foreground the author aims at through his work. This process also applies to Akutagawa Ryuunosuke's short story entitled Rashomon as the foreground of Konjakumonogatari, the 29th volume of the 18th story. This research aims to describe how the social, historical, and cultural writings by Akutagawa Ryunosuke in the Rashomon and compared with Konjakumonogatari, using the Aesthetic Repertoire theory proposed by Wolfgang Iser. The process through which, among others, grouping the data to be analyzed is related to social, historical, and cultural norms of Japanese society. Next, compare the data to see the relationship between Rashomon and Konjakumonogatari. The results showed (1) There are similarities between social, historical, and cultural similarities between literature and reality, (2) Social norms indicate the life of the Japanese lower class in the Heian period called Genin, (3) Historical norms show the dark conditions that Japanese people went through in the Heian era, because of the many problems that occurred at that time, and (4) Cultural Norms show the efforts made by Japanese people in the Heian period to survive despite hurting others.
Edo Period Masculinity In Sugawara Denju Tenarai Kagami (1746)
Authors: Ariefa Nina Alia
Published: July 2023

As part of cultural documentation, literary works have the ability to record the conditions of the times and society in a nation, including gender issues as values that are built, emphasized, and disseminated in the community. As a period characterized by feudal society under the leadership of the Tokugawa clan, the Edo period (1603-1868) is known as the golden age of the development of traditional Japanese culture. Through a study of the play Sugawara Denju Tenarai Kagami (1746) which is one of the masterpieces of the Edo period, this study reveals the representation of masculinity that shows a hierarchical social construction between men and women. The method used in this study is a qualitative analysis through a gender approach from Wharton (2005) and Lindsey (2016), as well as a feminist criticism approach from Tyson (2015). The construction of masculinity in this play highlights the depiction of men as knights, which are associated with courage, loyalty, integrity, toughness and self-respect. In addition, the concept of masculinity is depicted as strongly tied to the determination of hierarchical and patriarchal social structures, as well as being a reflection of the gender ideology of the Edo period which puts the superiority of men as the central figure in socio-cultural life. The depiction of male qualities and characters that outperform female characters in this text shows the text’s strategy in strengthening the patriarchal paradigm, and clearly shows the function of this text as a locus for strengthening the implementation of patriarchy in the Edo period.
Komparasi Struktur Imaji dalam Lirik Lagu "Kokoro No Tomo" dengan Versi Remake oleh Grup Musik Zivilia
Authors: Darmawan Ricky , Kistanto Nurdien H , Suryadi M
Published: July 2023

Image is a word or a word arrangement that has the effect of clarifying or concretizing what the poet has stated. Images in literary works include many kinds of things related to human senses. This study compares and equates the emphasis on figurative language style in the lyrics of songs with two language translation versions of the same name, Kokoro no Tomo which was set to music by Mayumi Itsuwa in 1980 and popularized in the world. Translated in Indonesian with the title Kokoro no Tomo by the music group Zivilia. The method used by the author in the research is a qualitative method, focusing on comparing the images in the lyrics of the song. The results of visual exploration of similarities and differences in the lyrics of the two songs include (1) sensational images, (2) tactile images, and (3) visual images. an illustration that both versions provide an equivalent statement with sentences from the Japanese and Indonesian versions. With the difference in the use of images, the lyrics of the two songs have adjusted the content to suit the musical needs of the people, especially in this case, the people of Indonesia