bluuebunny/crossref_metadata_2025 huggingface dataset:
More Effective Mobilization of Hg2+ from Human Serum Albumin Compared to Cd2+ by L-Cysteine at Near-Physiological Conditions
Authors: Gautam Astha , Gailer Jürgen
Published: July 2023

Although chronic low-level exposure to Hg2+ and Cd2+ causes human nephrotoxicity, the bioinorganic processes that deliver them to their target organs are poorly understood. Since the plasma protein human serum albumin (HSA) has distinct binding sites for these metal ions, we wanted to gain insight into these translocation processes and have employed size-exclusion chromatography coupled on-line to an inductively coupled plasma atomic emission spectrometer using phosphate-buffered saline mobile phases. When HSA ‘labeled’ with Hg2+ and Cd2+ (1:0.1:0.1) using 300 μM of L-methionine was analyzed, the co-elution of a single C, S, Cd, and Hg peak was observed, which implied the intact bis-metalated HSA complex. Since human plasma contains small molecular weight thiols and sulfur-containing metabolites, we analyzed the bis-metalated HSA complex with mobile phases containing 50–200 µM of L-cysteine (Cys), D,L-homocysteine (hCys), or glutathione (GSH), which provided insight into the comparative mobilization of each metal from their respective binding sites on HSA. Interestingly, 50 µM Cys, hCys, or GSH mobilized Hg2+ from its HSA binding site but only partially mobilized Cd2+ from its binding site. Since these findings were obtained at conditions simulating near-physiological conditions of plasma, they provide a feasible explanation for the higher ‘mobility’ of Hg2+ and its concomitant interaction with mammalian target organs compared to Cd2+. Furthermore, 50 µM Cys resulted in the co-elution of similar-sized Hg and Cd species, which provides a biomolecular explanation for the nephrotoxicity of Hg2+ and Cd2+.
Synergistic Effect of Treatment with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Lipopolysaccharide on the Inflammatory Response of Porcine Pulmonary Microvascular Endothelial Cells
Authors: Yao Xinyue , Dai Wanwan , Yang Siyu , Wang Zhaoli , Zhang Qian , Meng Qinghui , Zhang Tao
Published: July 2023

The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) often causes secondary bacterial infection in piglets, resulting in inflammatory lung injury and leading to high mortality rates and significant economic losses in the pig industry. Microvascular endothelial cells (MVECs) play a crucial role in the inflammatory response. Previous studies have shown that HP-PRRSV can infect porcine pulmonary MVECs and damage the endothelial glycocalyx. To further understand the role of pulmonary MVECs in the pathogenesis of HP-PRRSV and its secondary bacterial infection, in this study, cultured porcine pulmonary MVECs were stimulated with a HP-PRRSV HN strain and lipopolysaccharide (LPS). The changes in gene expression profiles were analyzed through transcriptome sequencing, and the differentially expressed genes were verified using qRT-PCR, Western blot, and ELISA. Furthermore, the effects on endothelial barrier function and regulation of neutrophil trans-endothelial migration were detected using the Transwell model. HP-PRRSV primarily induced differential expression of numerous genes associated with immune response, including IFIT2, IFIT3, VCAM1, ITGB4, and CCL5, whereas LPS triggered an inflammatory response involving IL6, IL16, CXCL8, CXCL14, and ITGA7. Compared to the individual effect of LPS, when given after HN-induced stimulation, it caused a greater number of changes in inflammatory molecules, such as VCAM1, IL1A, IL6, IL16, IL17D, CCL5, ITGAV, IGTB8, and TNFAIP3A, a more significant reduction in transendothelial electrical resistance, and higher increase in neutrophil transendothelial migration. In summary, these results suggest a synergistic effect of HP-PRRSV and LPS on the inflammatory response of porcine pulmonary MVECs. This study provides insights into the mechanism of severe lung injury caused by secondary bacterial infection following HP-PRRSV infection from the perspective of MVECs, emphasizing the vital role of pulmonary MVECs in HP-PRRSV infection.
The Extract of Scutellaria baicalensis Attenuates the Pattern Recognition Receptor Pathway Activation Induced by Influenza A Virus in Macrophages
Authors: Yang Mingrui , Ma Luyao , Su Rina , Guo Rui , Zhou Na , Liu Menghua , Wu Jun , Wang Yi , Hao Yu
Published: July 2023

The dual strategy of inhibiting the viral life cycle and reducing the host inflammatory response should be considered in the development of therapeutic drugs for influenza A virus (IAV). In this study, an extract of Scutellaria baicalinase (SBE) containing seven flavonoids was identified to exert both antiviral and anti-inflammatory effects in macrophages infected with IAV. We performed transcriptome analysis using high-throughput RNA sequencing and identified 315 genes whose transcription levels were increased after IAV infection but were able to be decreased after SBE intervention. Combined with Gene Ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis, these genes were mainly involved in TLR3/7/8, RIG-I/MDA5, NLRP3 and cGAS pattern recognition receptor (PRR)-mediated signaling pathways. SBE inhibited the transcription of essential genes in the above pathways and nuclear translocation of NF-κB p65 as confirmed by RT-qPCR and immunofluorescence, respectively, indicating that SBE reversed PR8-induced over-activation of the PRR signaling pathway and inflammation in macrophages. This study provides an experimental basis for applying Scutellaria baicalensis and its main effects in the clinical treatment of viral pneumonia. It also provides novel targets for screening and developing novel drugs to prevent and treat IAV infectious diseases.
Genomic Characteristics of Feline Anelloviruses Isolated from Domestic Cats in Shanghai, China
Authors: Gao Jun , Liu Chengqian , Yi Jianzhong , Shi Ying , Li Hong , Liu Huili
Published: July 2023

Viral metagenomics techniques allow the high-throughput discovery of possible pathogens carried by companion animals from their feces and other excreta. In this study, the viral metagenomics of 22 groups of fecal samples from domestic cats revealed a high prevalence of feline anelloviruses (FcTTV) infection in domestic cats in Shanghai, China. Serum samples from 30 cat individuals were further detected by polymerase chain reaction, and an average positive rate of 36.67% (11/30) of FcTTV infection was found. Next, the full-length sequences of five Shanghai FcTTV variants were obtained and submitted to GenBank with access numbers OP186140 to OP186144. Phylogenetic analysis indicates that the Shanghai FcTTV variants have relatively consistent genomic characteristics, with two variants from Zhejiang 2019 and one variant from the Czech Republic 2010. The recombination event analysis of the variants showed that one variant (OP186141_SH-02) had a primary parental sequence derived from a variant (KM229764) from the Czech Republic in 2010, while the secondary parental sequence was derived from OP186140_SH-01. The results revealed that FcTTV infection is prevalent in domestic cats and that the use of viral metagenomics to rapidly identify some infecting viruses whose hosts lack clinical features would be an effective approach.
SARS-CoV-2 Surveillance in Hospital Wastewater: CLEIA vs. RT-qPCR
Authors: Thongpradit Supranee , Chanprasertyothin Suwannee , Pasomsub Ekawat , Ongphiphadhanakul Boonsong , Prasongtanakij Somsak
Published: July 2023

The utilization of wastewater as a community surveillance method grew during the COVID-19 epidemic. COVID-19 hospitalizations are closely connected with wastewater viral signals, and increases in wastewater viral signals can serve as an early warning indication for rising hospital admissions. While reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) is the most often used approach for detecting SARS-CoV-2 in wastewater, chemiluminescence enzyme immunoassay (CLEIA) is an alternative automated method. In two assays, 92 wastewater grab samples from a hospital were investigated for the presence of SARS-CoV-2, expected for continuous and monitoring SARS-CoV-2 surveillance. One was in the RT-qPCR nucleic acid test, and another was in the CLEIA assay quantitative antigen test. In 24/92 (26.09%) of the wastewater samples, RT-qPCR identified at least two SARS-CoV-2 genes (ORF1ab, N, or S genes). CLEIA, on the other hand, detected SARS-CoV-2 antigen in 39/92 (42.39%) of the samples. CLEIA demonstrated a low sensitivity and specificity of sensitivity of 54.2% (95% CI: 44.0–64.3%) and 61.8% (95% CI: 51.8–71.7%), respectively, as compared to RT-qPCR. The κ coefficient indicated slight agreement between assay. Then, the CLEIA assay cannot replace molecular-based testing like RT PCR for determining SARS-CoV-2 in hospital wastewater.
A Qualitative Approach to Understand Transitions toward One Water in Urban Areas across North America
Authors: Dezfooli Donya , Bolson Jessica , Arabi Mazdak , Sukop Michael C. , Wiersema Inge , Millonig Sarah
Published: July 2023

Urban water systems across the world are grappled with growing social and environmental pressures. To address these pressures, a transition from traditional water management systems towards a more integrated and sustainable approach known as “One Water” is vital. Although cities are enthusiastic about a One Water paradigm, there is a limited scholarly understanding of how to enable this transition. This study, therefore, aimed to improve intellectual comprehension of the factors that influence One Water transitions based on a series of expert interviews that were conducted with a number of utilities across North America. It was found that achieving social–environmental justice is among the most prominent drivers for utilities to start their transition, followed by concerns about climate change, water quality impairments, groundwater depletion and subsidence, and population growth. Our findings revealed that several critical barriers including a lack of regulatory frameworks and existing institutional siloes impede the transition toward One Water. Additionally, our thematic framework revealed that technological, cultural, and institutional actions are required to enable One Water transitions. However, the frequency of actions in the thematic framework sheds light on the point that cultural, institutional, and regulatory solutions are needed more than technological innovations to support the paradigm shift. Finally, our efforts identified nine key elements of a “One Water City” that could be used to characterize progress towards implementation of One Water approaches. Insights from this paper not only provide water managers with an understanding of the perspectives and actions required for enabling the One Water paradigm shift, but also can be used to develop a framework for self-assessment.
Numerical and Experimental Study on the Process of Filling Water in Pressurized Water Pipeline
Authors: Hu Jianyong , Wang Qingbo , Zhang Yuzhou , Meng Zhenzhu , Zhang Jinxin , Fan Jiarui
Published: July 2023

As an important working condition in water conveyance projects, the water filling process of pipelines is a complex hydraulic transition process involving water–air two-phase flow with sharp pressure changes that can easily cause pipeline damage. In light of the complex water–air two-phase flow during pipeline water filling, this study explores the water filling process of right-angle elbow pressure pipelines using CFD numerical simulations and physical model experiments, analyzing changes in water phase volume fraction, water-gas two-phase flow patterns, and hydraulic parameters in the pipeline under low flow rate conditions of 0.6 m/s and high flow rate conditions of 1.5 m/s. Results show that under low flow rate conditions, there is more local trapped gas at the top of the pipeline, causing negative pressure at local high points in the pipeline and forming a vacuum. Under high velocity conditions, water-gas two-phase flow changes more frequently in the pipeline, with a large number of bubbles collapsing at the top, resulting in large fluctuations in pipeline pressure. Finally, through physical experiments, the main flow patterns during water filling in right-angle elbows are verified and analyzed. These results have certain reference significance for formulating safe and efficient water filling velocity schemes for pressurized pipelines.
Health Risks to Communities and Athletes Associated with Swimming, Wading, and Sailing in Water Bodies of Brazil’s Guanabara Bay Basin
Authors: Sklar Rachel , Chabrelie Alexander E. , Carreira Renato S. , Gurian Patrick L. , Mitchell Jade
Published: July 2023

Guanabara Bay has been known to be polluted with trash and sewage from the surrounding areas, but health risks from recreational contact with water in the basin have not been well characterized. In this paper, fecal indicator bacteria (FIB) monitoring data are used to predict risks in three different exposure scenarios: (1) bathing in freshwater rivers that discharge into Guanabara Bay, (2) wading in these freshwater rivers, and (3) sailing in Guanabara Bay. Concentrations of indicator bacteria in river samples were measured directly, and concentrations of indicator bacteria in bay samples were sourced from publicly available government data sets. Ratios between pathogens and fecal indicator concentrations were used to estimate risks for five selected pathogens based on the indicator concentrations. The median risk of disease estimated from E. coli indicator concentrations was 1.0, 9.9 × 10−1 and 8.2 × 10−4 for the swimming, wading, and sailing exposure pathways, respectively. Risks estimates based on concentrations of the enterococci indicator bacteria in the sailing exposure scenario were comparable, at 3.4 × 10−4. The sum of total risk estimated from the five selected pathogens was 5.9 × 10−1, 3.6 × 10−1, and 1.0 × 10−3 for the swimming, wading, and sailing exposure pathways, respectively. Estimated risks of swimming and wading in the rivers far exceeded risks associated with U.S. recreational contact standards, while estimated risks for sailing in the bay were well below these risk guidelines. The 95th percentile of the sailing risk was estimated to exceed the U.S. recreational contact risk level. This paper exemplifies an approach to conducting quantitative microbial risk assessments when only fecal indicator bacteria data are available. Context-specific data on the relevant exposure routes, exposure frequency, and site-specific indicator: pathogen ratios were lacking, which ultimately led to uncertainty in the model. This study is intended to provide a framework for estimating GI risk based on fecal indicator concentrations while acknowledging that the substantial variation in indicator:pathogen ratios make the results of such efforts uncertain.
Tests of historical, cultural and patriotic orientation for student public posts in social networks: the experience of creating
Authors:   Department of Internal and External Communications of St. Petersburg Mining University of Empress Catherine II, Tikhomirov S.A.
Published: July 2023

The article contains examples of creating tests for students timed to memorable dates and posted in the public of structural divisions of universities in social networks as a tool of historical and cultural education and the formation of patriotism.
Areas of application of unmanned aircraft in the world
Authors:   Federal Scientific Agroengineering Center VIM, Russian Federation, Moscow, Zakharova N. I. , Litvinov M. A. ,   Federal Scientific Agroengineering Center VIM, Russian Federation, Moscow
Published: July 2023

Unmanned aircraft have gained wide popularity in various spheres of life. In particular, civilian applications range from precision farming to the delivery of goods and entertainment. The growth in the use of drones indicates the development of technology in various spheres of life. Digital agriculture is becoming one of the most developing areas of application of unmanned aircraft.
Application of unmanned air systems in agriculture
Authors:   Federal Scientific Agroengineering Center VIM, Russian Federation, Moscow, Litvinov M. A. , Kuprin A. A. ,   Federal Scientific Agroengineering Center VIM, Russian Federation, Moscow
Published: July 2023

The purpose of this article is to consider the use of unmanned aerial systems (UAS) in agriculture. UAVs have great potential in many agricultural tasks. This article summarizes the current state of drone technology and its applications in agriculture, including plant health monitoring, weed control, spraying, and other agricultural operations.
Increased reliability Cleanup engine and transmissions of tractors using nanomaterials
Authors:   Federal State Budgetary Scientific Institution ", Lyalyakin V. P. ,   Federal Scientific Agroengineering Center VIM",   , Moscow, Russia, Gitelman D. A. ,   ChGAA, Solovyev R. Yu. , Olkhovatsky A. K.
Published: July 2023

The article presents some of the results and the results of the study to reduce the operational running and improving engine reliability, renovated CLD SHP, using nanomaterials.
Étude, en inter-didactique des mathématiques et de la physique, de l'acquisition de la loi d'Ohm au collège : espace de réalité / Study, in inter-didactics of mathematics and physics, about acquisition of Ohm's law in high school : space of reality
Authors: Malafosse Didier , Lerouge Alain , Dusseau Jean-Michel
Published: July 2023

Many researchers have asked the question whether and in what conditions the didactic concepts in a given discipline can be transposed to another. We have examined the relations between mathematics and physics, taking Ohm’s law as an example, the first law of physics written and represented in mathematical form in French high school. Our observations led us to define a theoretical model based on two didactical notions developed specifically in mathematics frame and register by adding a new element taken from physics which we call space of reality.
Bandit Approach to Conflict-Free Parallel Q-Learning in View of Photonic Implementation
Authors: Shinkawa Hiroaki , Chauvet Nicolas , Röhm André , Mihana Takatomo , Horisaki Ryoichi , Bachelier Guillaume , Naruse Makoto
Published: July 2023

Recently, extensive studies on photonic reinforcement learning to accelerate the process of calculation by exploiting the physical nature of light have been conducted. Previous studies utilized quantum interference of photons to achieve collective decision-making without choice conflicts when solving the competitive multi-armed bandit problem, a fundamental example in reinforcement learning. However, the bandit problem deals with a static environment where the agent’s actions do not influence the reward probabilities. This study aims to extend the conventional approach to a more general type of parallel reinforcement learning targeting the grid world problem. Unlike the conventional approach, the proposed scheme deals with a dynamic environment where the reward changes because of the agent’s actions. A successful photonic reinforcement learning scheme requires both a photonic system that contributes to the quality of learning and a suitable algorithm. This study proposes a novel learning algorithm, a modified bandit Q-learning method, in view of a potential photonic implementation. Here, state–action pairs in the environment are regarded as slot machines in the context of the bandit problem and a change in
Q
-value is regarded as the reward of the bandit problem. We perform numerical simulations to validate the effectiveness of the bandit algorithm. In addition, we propose a parallel architecture in which multiple agents are indirectly connected through quantum interference of light and quantum principles ensure the conflict-free property of state–action pair selections among agents. We demonstrate that parallel reinforcement learning can be accelerated owing to conflict avoidance among multiple agents.
Urbanization in Sub-Saharan Africa and its characteristics
Authors:   Society for International Cultural Institute, Lim Junghae
Published: July 2023

Africa is the fastest urbanizing continent in the world. The population of Africa is expected to double by 2050 and this growth is due in large part to the large urban population growth. It is generally accepted that urbanization results from rural exodus, but as far as Africa is concerned, it is urban fertility that plays an important role. Moreover, this high fertility also applies in rural regions, unlike on other continents. This can be seen in particular in the two sub-Saharan countries where the fertility rate is very high: Nigeria and Ethiopia. Africa is thus exposed to the challenges of rapid population growth and rapid urbanization. And this leads to characteristics specific to this continent.
The purpose of this article is to show the particularities of the urbanization of Africa that are specific to it. No continent in the world has experienced it at such speed. We will focus particularly on certain sub-Saharan countries which are characterized by their rapid increase in population. Such a study will make it possible on the one hand, to better prepare what will be necessary in the futur and on the other hand, to make known the advantage as well as the obstacles that foreign companies could face.
Beton-Dolgulu Çelik Tüplü Kompozit Kolonların Nihai Eksenel Yük Taşıma Kapasitesi Tahmininde MARS, RVM ve ANN-Tabanlı Modellenmesinin Karşılaştırılması
Authors: Avcı-karataş Çigdem
Published: July 2023

Beton-dolgulu çelik tüplü kompozit kolonlar (BDÇTKK), özellikle büyük eğilme rijitlikleri, süneklik ve enerji sönümleme kapasitesi bakımından yapı davranışını iyileştirici/geliştirici bir tercih haline gelmiştir. Çok değişkenli adaptif regresyon eğrileri (MARS), ilgililik vektör makinesi (RVM), ve yapay sinir ağları (ANN)-tabanlı modellere dayalı pratik tasarım metodolojisi yaklaşımları arasındaki karşılaştırmalar Avcı Karataş tarafından önceki çalışmalarında sunulmuştur. Bu araştırma makalesinde, literatürde geliştirilmiş üç boyutlu (3D) doğrusal olmayan sonlu elemanlar yöntemi (FEM) (3D-FEM) ve basitleştirilmiş sayısal/numerik modelleme (NM) sonuçları, dairesel ve kısa/stub BDÇTKK’ın nihai yük taşıma kapasitesinin tahmin edilmesine yönelik yazarın söz konusu bu çalışmalarında sunulan hesaplama yöntemleriyle karşılaştırılmıştır. Modellemede daha doğru bir tahmin sağlamak için dairesel BDÇTKK'ın geometrik ve mekanik özelliklerinden kapsamlı bir deneysel veri seti/kümesi sunulmuştur. Kompozit kolon yükseklik, kesit çapı, çelik tüp et kalınlığı, çelik akma ve kuşatılmamış beton basınç dayanımları, çelik ve beton elastisite modülü parametreleri, deneysel veri setinin geometrik ve malzeme karakteristikleridir. Dairesel kısa BDÇTKK’ın, 3D-FEM, NM ile MARS, RVM ve ANN-tabanlı modellemeye dayalı tahmin edilen nihai eksenel basınç yükü kapasitesinin, deneysel olarak ölçülen değerlerle karşılaştırılabilir olduğu, bu özgün çalışma kapsamında detaylı olarak incelenmiştir. Tahmin edilen ile deneysel nihai eksenel yük oranlarının minimum ve maksimum değerleri, MARS-tabanlı modelde, ((P_u^MARS)⁄(P_u^E )), 0.87 ile 1.10 aralığında, RVM-tabanlı modelde, (P_u^RVM/P_u^E), 0.90 ile 1.06 arasında, ANN-tabanlı modelde, ((P_u^ANN)⁄(P_u^E )), 0.92 ile 1.04 arasında değiştiği bulunmuştur. MARS ve RVM-tabanlı modeller kadar güçlü istatistiksel modelleme araçlarından biri olan ANN-tabanlı modellemeden, bu makale kapsamında incelenen deneysel veri sonuçlarıyla en uyumlu ve yakın performans sonuçları elde edilmiştir.
HoloWall: A Windbreak Wall Using Salvaged Timber with Mixed Reality Aided Construction
Authors:   Cornell University, Bae Jiyoon , Lok Leslie ,   Cornell University
Published: July 2023

HoloWall is a wall assembly installation that integrates mixed reality (MR) protocols with nonuniformly sized lumber to develop a customized hollow-core cross-laminated timber (HCCLT). Referencing traditional windbreak shelters in agricultural landscapes, the HoloWall is a repository of cultural traces for the emblematic and utilitarian windbreak walls that protect livestock and buildings. Constructed from locally sourced salvaged wood, the prototype sat loosely between trees in the Arts Quad at Cornell University to provide shelter from prevailing wind across the valley. The prototype develops a material language of lamination that peels away in calibrated gradients to generate structural and visual porosity.
Device-Media-Architecture: Julia Child’s Kitchens
Authors:   University of New Mexico, Fries-Briggs Gabriel
Published: July 2023

This paper traces a lineage of device-as-architecture through the mediatization of Julia Child’s kitchens. A historical survey of the changes to her kitchen and its relationship to interior design during the latter half of the 20th century suggest a reading of interior architecture not as a means to house new technology but rather as composed by technology and devices. Counter to Ryener Banham’s projection of a future where interior technologies give shape to an architectural exterior, Child’s kitchen reflects a growing trend in the second half of the 20th century in which tool-based clutter and the interior’s autonomy from the exterior, best characterized by the storage-accumulation aesthetics of lofts and garages, dominated. Rather than necessarily limiting the role of the architect to exterior form, the elevation of gadgets, gizmos, and devices to the status of architecture opened up the possibility for a functional user-driven design agency. Analysis of the kitchen backdrops that served as sets for her various cooking shows as well as the cataloging and installation of her kitchen in the Smithsonian Museum of American History reveal an evolution of architectural interiors that shifted with her own identity and paralleled shifting domestic aesthetics away from minimalism, modernism, and post-World War II home automation. This examination of Julia Child’s kitchens frame a narrative of domestic design beginning in the 1960s when tools and technology were increasingly seen as the backbone of a new ecological or environmental society. Julia Child’s display of functional clutter took part in popularizing a new craft aesthetic where tools were prominently displayed and often collectively used. The images of her kitchen, spanning four decades, provide a context for changing cultural and architectural discourse in relation to the aesthetics of function, devices, media, and attitudes toward preservation.
Método mixto de investigación: Cuantitativo y cualitativo
Authors: Medina Romero Miguel Ángel , Hurtado Tiza David Raul , Muñoz Murillo José Patricio , Ochoa Cervantez Dani Oved , Izundegui Ordóñez Gerardo
Published: July 2023

El objetivo de este libro es explorar y comprender los diferentes aspectos de la investigación mixta, incluyendo sus características, aplicaciones, desafíos y consideraciones éticas. También examinaremos las futuras direcciones y avances en este campo, así como el impacto de la integración de métodos mixtos con nuevas tecnologías. A través de esta exploración, buscamos proporcionar una visión integral y enriquecedora de la investigación mixta y su relevancia en la generación de conocimiento científico riguroso. Esta lectura está dirigida a estudiantes, investigadores y profesionales en el ámbito académico y científico que estén interesados en ampliar sus conocimientos sobre la investigación mixta. También puede ser de interés para aquellos que deseen utilizar métodos mixtos en sus propias investigaciones y deseen comprender mejor los fundamentos teóricos y metodológicos de este enfoque. Al participar en este recorrido, los lectores aprenderán sobre los conceptos clave asociados con la investigación mixta, incluyendo los enfoques cuantitativos y cualitativos, la integración de datos, finalmente, examinaremos las tendencias emergentes en métodos mixtos y la integración de nuevas tecnologías en la investigación mixta. Los lectores estarán equipados con los conocimientos necesarios para aplicar y aprovechar al máximo la investigación mixta en sus propias investigaciones y contribuir al avance del conocimiento científico.
Multi-beam X-ray optical system for high-speed tomography using a σ-polarization diffraction geometry
Authors: Voegeli Wolfgang , Liang Xiaoyu , Shirasawa Tetsuroh , Arakawa Etsuo , Hyodo Kazuyuki , Kudo Hiroyuki , Yashiro Wataru
Published: July 2023

A multi-beam X-ray optical system using a σ-polarization diffraction geometry is proposed and its potential for high-speed tomography using synchrotron radiation is experimentally evaluated. Projection images of a sample are obtained simultaneously from different directions with X-ray beams generated by diffraction of a white synchrotron radiation beam at silicon single crystals. This makes it possible to record a tomographic dataset without rotation of the sample or X-ray source. Data sets of two samples obtained in a proof-of-principle experiment with an exposure time of 1 ms were successfully reconstructed using an advanced compressed-sensing algorithm.
Analisis Numerik Bird Strike Pada Radome Dengan Struktur Sandwich
Authors: Zhafrando Muhammad Rayhan , Afandi Sahril , Yuniarti Endah
Published: July 2023

Bird strike adalah ancaman terhadap keselamatan penerbangan dan menjadi salah satu penyebab kecelakaan dengan korban jiwa manusia. Tugas akhir ini bertujuan untuk mendapatkan respon tabrakan dari radome dengan konstruksi komposit laminate dan sandwich terhadap bird strike. Selain itu, penelitian ini juga bertujuan untuk mendapatkan konstruksi terbaik berdasarkan studi kasus orientasi serat, pengaruh konstruksi sandwich, serta variasi kecepatan tumbukan. Analisis numerik menggunakan aplikasi elemen hingga ABAQUS. Metode Smooth Particle Hydrodinamics (SPH) digunakan untuk memodelkan material burung karena memiliki keuntungan dari akurasi hasil, waktu dimodelkan menggunakan crushable foam plasticity di ABAQUS. Variasi kecepatan tabrakan antara burung dan radome adalah 80,116, dan 150 m/s. Model radomedi-fixed pada bagian tepi. Berdasarkan hasil yang diperoleh, perpindahan terbesar terjadi pada radomedengan konstruksi laminate menggunakan orientasi serat quasi-isotropic pada kecepatan tumbukan 150 m/s. Pada konstruksi sandwich, perpindahan lebih kecil dibandingkan konstruksi laminate. Konstruksi sandwichmampu memberikan kekakuan dan kekuatan relatif yang lebih tinggi dibandingkan konstruksi laminate, yaitu 2.41 kali lebih kaku dan 1.86 kali lebih kuat di kecepatan tumbukan yang sama. Orientasi serat komposit cross-ply menunjukkan hasil 0.97% lebih kuat dibandingkan orientasi quasi-isotropic.
تأثير حقن الستيرويد البنائي السستانون وزيت السمسم على مستويات أنزيمات الكبد مع التغيرات النسجية المرضية في ذكور الجرذان
Authors: علي شلش سلطان  , رشا عبد الامير عبد اللطيف
Published: July 2023

هدفت الدراسة الحالية الى معرفة تأثير حقن السستانون وهو من المركبات الستيرويدية البنائية وكذلك زيت السمسم على بعض الوظائف الفسيولوجية في كبد  ذكور الجرذان والتي شملت قياس مستويات أنزيمات الكبد ( SGOT , SGPT , ALP ) أما الدراسة النسجية المرضية فقد تضمنت التغيرات النسجية المرضية التي يحدثها السستانون وزيت السمسم  في أكباد الجرذان .

تضمنت حيوانات التجربة 25 جرذيا ً ذكرا ً من نوع Sprague – Dawely والتي قسمت الى خمسة مجاميع أضافية ( Subgroups ) بالتساوي . ضمت مجاميع السيطرة السالبة ( علف وماء ) ، المجموعة الثانية سيطرة موجبة ( 1 مل / كغم من وزن الجسم زيت السمسم جرعة واطئة ) المجموعة الثالثة سيطرة موجبة ( 2 مل / كغم من وزن الجسم زيت السمسم جرعة عالية ) المجموعة الرابعة سستانون ( 10  ملغم /كغم  من وزن الجسم جرعة واطئة ) ، المجموعة الخامسة سستانون ( 20 ملغم / كغم من وزن الجسم جرعة عالية ) .حقنت مجاميع الحيوانات أسبوعيا  لمدة  6 أسابيع بالسستانون وزيت السمسم بالعضل ثم قتلت في نهاية الاسبوع السادس .بينت النتائج أرتفاعا ً معنويا ً ( P<0.05) في مستويات أنزيمات الكبد (SGOT , SGPT,ALP) في المجاميع المحقونة بالسستانون ( 10 و 20  ملغم / كغم من وزن الجسم ) .بينما اظهرت مجموعتي السيطرة الموجبة الاولى والثانية ( زيت السمسم ) أنخفاضا ً غير معنوي( P>0.05) في مستويات أنزيمات ( SGOT,SGPT ) وأنخفاضا ً معنويا ً ( P<0.05) في مستوى أنزيم ALP .تميزت التغيرات النسجية المرضية في أكباد الجرذان بما يلي :
سيمائية البنية الشكلية للمنمنمات الإسلامية
Authors: م.  منى كاظم عبد دواس
Published: July 2023

منذ بدايات الإنسان الأولى، كان البحث عن وسيلة للتعبير هدفاً حقيقياً في التواصل مع بني جنسه وبيئته وإن اختلفت هذه الوسائل من بيئة إلى أخرى أو من زمان إلى آخر.إلا أن النتيجة التي تمخضت عن ذلك هو الوصول إلى لغة كانت تارة مكتوبة أو مقروءة أو أشارية أو حركية أو أيقونية، ووصول الإنسان إلى اللغة إنما فتح الباب أمامه للتعبير عن افكاره ويحدد علاقته وموقفه بالآخرين والبيئة وما تكتنفه في الزمان والمكان.

    وتشكل المنمنمات العربية والإسلاميةوليدة المخطوطات التي نقلت لنا تلك المعرفة واحدة من المظاهر الفنية والثقافية والاجتماعية التي عكست وإلى حد كبير ثقافة تلك المجتمعات، حتى عدت أحد أهم فنون الكتاب الرفيعة القائمة بذاتها والتي تعكس مضامينه الفكرية. وظهر هذا اللون الخاص من فن التصوير، الذي يُعرف اليوم باسم المنمنمات ومن الطبيعي أن تحتاج الكثير من النصوص المعرفية التي تتضمنها المخطوطات بمختلف مواضيعها إلى رسوم توضيحية تجسد فكرة الموضوع وتنقل العين والفكر إلى المشهد سواء كان واقعياً أو خيالياً حتى يمتلك قدرة أكثر على التأثير والإقناع ،
Pengaruh Aromaterapi Lavender terhadap Skala Nyeri pada Ibu Post Sectio Caesarea di Rumah Sakit Ari Canti Gianyar Tahun 2022
Authors: Dewi A. A. Santi , Ni Made Ari Febriyanti  , Yustiari Ni Wayan Nik
Published: July 2023

Data dari Sistem Informasi Rumah  Sakit (SIRS) Dinas Keseahatan Provinsi Bali, total persalinan di Bali sebanyak 21.965 pada Tahun 2020 dan 58,7% dilakukan dengan metode operasi caesarea. Operasi section caesarea menyebabkan nyeri dan dapat menimbulkan masalah salah satunya kesulitan perawatan bayi dan tidak sedikit menyebabkan pasien menunda pemberian ASI sejak awal kelahiran. Upaya yang dilakukan untuk menurunkan nyeri post sectio caesarea dapat menggunakan metode farmakologi maupun nonfarmakologi. Salah satu upaya metode nonfarmakologi adalah Aromaterapi lavender. Tujuan penelitian ini untuk mengetahui perbedaan skala nyeri pada ibu post section caesarea pada kelompok intervensi Aromaterapi Lavender (sebelum-sesudah) dan kelompok Kontrol (sebelum-sesudah). Metode penelitian  ini  menggunakan  desain  quasi experiment dengan rancangan Pre-post Test Design (with control group). Teknik sampling purposive sampling dengan jumlah sampel 40 orang yaitu 20 kelompok intervensi dan 20 kelompok control. Cara pengumpulan data menggunakan lembar observasi skala nyeri Numeric Rating Scale (NRS). Analisa data menggunakan uji paired t-test. Hasil penelitian menunjukkan bahwa p velue kelompok intervensi (nilai p = 0,000<0.05) dan kelompok kontrol (nilai p = 0,055>0,05). Kesimpulan penelitian ada perbedaan post section caesarea pada kelompok intervensi Aromaterapi Lavender (sebelum-sesudah) dan tidak ada perbedaan skala nyeri pada ibu post section caesarea pada kelompok Kontrol (sebelum-sesudah).
Penerapan Pijat Oksitosin Pada Ibu Post Sectio Caesarea Dengan Masalah Menyusui Tidak Efektif
Authors: Kurniawaty Kurniawaty , Sunarmi Sunarmi , Exwa Wilaouda Rarippta
Published: July 2023

Latar Belakang; Target pencapaian air susu ibu (ASI) sulit dicapai disebabkan karena salah satu disebabkan ASI tidak keluar. Penurunan produksi ASI pada hari-hari pertama melahirkan disebabkan oleh kurangnya rangsangan hormon prolaktin dan oksitosin yang berperan dalam produksi ASI. Oleh sebab itu, perlunya usaha untuk menstimulasi hormon prolaktin dan oksitosin pada ibu pasca persalinan dengan cara pijat oksitosin. Tujuan penelitian diketahuinya penerapan pijat oksitosin terhadap ketidakefektifan proses menyusui pada ibu post sectio caesarea. Metode; Jenis penelitian ini adalah deskriptif analitik dalam bentuk studi kasus dengan pendekatan asuhan keperawatan yang meliputi pengkajian, diagnosa, rencana keperawatan, implementasi dan evaluasi keperawatan. Subyek penelitian dua orang ibu post sectio caesarea dengan masalah ketidakefektifan proses menyusui yang dirawat di RS Muhammadiyah Palembang, penelitian dilaksanakan pada bulan April 2022. Analisa data dilakukan dengan membandingkan teori dan data yang ditemukan. Hasil: Hasil penelitian yang didapatkan setelah penerapan pijat oksitosin pada pasien I dan pasien II yang dilakukan selama 2 hari dipagi dan sore hari dengan lama penerapan 5-10 menit didapatkan produksi ASI kedua pasien meningkat. Saran: dapat menerapkan pijat oksitosin sebagai salah satu acuan untuk membantu proses pengeluaran ASI.
Enabling Intelligent Omni-Surfaces in the Polarization Domain: Principles, Implementation and Applications
Authors: Palomares-Caballero Ángel , Molero Jiménez Carlos , Ghadi Farshad Rostami , López-Martínez F. Javier , Padilla Pablo , Morales-Jimenez David , Valenzuela-Valdés Juan
Published: July 2023

Wireless communications based on reconfigurable

intelligent surfaces (RIS) have upsurged as a key research topic in the communication-theoretic arena. Recently, the RIS concept has evolved into the so-called simultaneously transmitting and reflecting intelligent omni-surfaces (STAR-IOS, or simply IOS), which extend the RIS functionality by incorporating transmission (in addition to reflection) capabilities. To realize STAR-IOS, full and independent reconfiguration capabilities for both reflected and transmitted waves are crucially required. However, such full independent reconfiguration has thus far been hurdled by the intimate coupling between the transmission and reflection behaviour of the IOS elements. To overcome this challenge and realize the full potential of reconfigurable IOS-aided systems, we here advocate for the use of the polarization domain in the design and operation of STAR-IOS. Thanks to the polarization- dependent features of IOS elements, fully independent (reconfigurable) transmission and reflection modes can be delivered, thus bringing key performance improvements and opportunities for new communication scenarios.

[Comment: This work has been accepted in IEEE Communications Magazine]
Rulebook: An Architectural Pattern for Self-Amending Mechanics in Digital Games
Authors: Mizutani Wilson , Kon Fabio
Published: July 2023

Mechanics are one of the pillars of gameplay, enabled by the underlying implementation of the game. In particular, self-amending mechanics are mechanics that change themselves dynamically and are a common source of duplicate and coupled code because they occur in multiple situations using specific interactions. The Rulebook is an architectural pattern that generalizes how developers deal with these issues, based on a careful research process including a systematic literature review, semi-structured interviews with professional developers, and quasi-experiments. The pattern codifies changes to the game state as “effect” objects, which it matches against a dynamic pool of rules. Each rule may amend, resolve, or chain effects. This design prevents the rest of the game from becoming coupled to the specific interactions of these mechanics while also promoting an extensible and flexible structure for self-amendment. This paper details the Rulebook pattern and presents a case study demonstrating its design process in three different implementations of open-source jam games. Together with the typification of self-amending mechanics, this article formalizes a novel, state-of-the-art toolset for architecting games.
Machine Learning Based Coordination for IDMT Overcurrent and Earth Fault Relays
Authors: Khan Sultan Uddin , Hossain Md Shazzad , Sultan Ibrahim
Published: July 2023

 As machine learning continues to transform numerous industries, its application to smart grid systems has emerged as an intriguing area of investigation. Coordination of Inverse Definite Minimum Time (IDMT) overcurrent and earth fault relays is an essential aspect of smart grid operation, as it is crucial for ensuring grid stability and safety. In this study, we evaluate the relay coordination efficacy of a number of widely used machine learning models, including Linear Regression, Decision Tree, Random Forest, Support Vector Regression, and Gradient Boosting. Our research shows the gradient boosting model achieved the highest R2-score and the lowest Mean Square Error (MSE) and Mean Average Error (MAE) values in our simulation scenario demonstrating the superior efficacy of the gradient boosting model in accurately performing relay coordination, thereby providing a promising alternative to the conventional, calculation-intensive method. 
MEDIA PEMBELAJARAN GEOMETRI BERBANTU POWTOON DAN FILMORA UNTUK SISWA SMP/MTs
Authors: Heriyanto Mahista Reydita Putri , Fitriyani Harina
Published: July 2023

In general, learning mathematics requires learning media to understand abstract concepts for students. One of the mathematical concepts that is still considered difficult by students is a flat side shape. For this reason, it is necessary to develop mathematics learning video media that can help students’ difficulties. This study aims to produce Powtoon and Filmora assited mathematics learning video media on flat sided geometric material, and to determine its feasibility. The selected model is 4D which includes define, design, development, and dissemination. The test subjects were class VIII students at a Muhammadiyah middle school in Yogyakarta. Data analysis was carried out in a quantitative descriptive manner. The results showed that the media in the form of Powtoon and Filmora-assisted learning videos on Polyhedron were declared very feasible to use with percentages of 86.92% and 88.46%. The results of trials conducted in limited groups and groups showed an average percentage of student responses of 82,24%.
Konsep Kesamarataan dan Hak-hak Orang Kurang Upaya di Bawah Akta Orang Kurang Upaya 2008
Authors: Tahir Zulazhar , Mohd Yusoff Jal Zabdi , Thambapillay Sridevi , Abdul Rahman Ahmad Saufi
Published: July 2023

Akta Orang Kurang Upaya 2008 yang berkuat kuasa pada 7 Julai 2008 menunjukkan komitmen negara untuk membantu golongan orang kurang upaya (OKU). Objektif akta ini yang mengiktiraf kepentingan kebolehcapaian OKU terhadap persekitaran fizikal, sosial, ekonomi dan budaya, kesihatan dan pendidikan serta maklumat dan komunikasi yang membolehkan mereka upaya mengambil bahagian secara penuh dan berkesan dalam masyarakat. Hak OKU tidak boleh dilihat secara berasingan dengan prinsip hak asasi manusia. Hak asasi manusia dalam perspektif yang lebih luas telah menjadi semakin penting dalam dunia hari ini. Akta ini telah berjaya menukar konsep kebajikan kepada konsep hak bagi golongan OKU di Malaysia. Walaupun akta ini boleh disifatkan sebagai menyokong hak OKU, akta tersebut masih lemah dari segi penguatkuasaannya, walaupun telah digubal 14 tahun yang lalu. Oleh itu, makalah ini akan mengkaji dan membincangkan secara kritis perkembangan perundangan mengenai golongan OKU di Malaysia. Perkara ini berdasarkan fakta bahawa undang-undang merupakan komponen penting dalam usaha merealisasikan hasrat untuk melihat golongan OKU dilayan secara adil seperti individu yang berkeupayaan. Konsep kesaksamaan ini bukanlah sesuatu yang baharu kerana akta ini termaktub sebagai kebebasan asasi yang telah dijamin oleh Perlembagaan Persekutuan.
Trestný čin – objekt kriminálno-policajného poznania
Authors:   Akadémia Policajného zboru v Bratislave, Hullová Monika , Lisoň Miroslav
Published: July 2023

Autori v príspevku predkladajú odbornej verejnosti základnú štruktúru kriminálnej charakteristiky trestného činu, ktorá v súlade s ich názormi predstavuje významný poznávací prostriedok, ktorý príslušníci polície využívajú pri účelovej realizácii kriminálno-policajného poznania. Kriminálno-policajné poznanie je elementárnou súčasťou policajného konania. V súlade s platnou legislatívnou úpravou predstavuje systémovú realizáciu spravodajskej činnosti, operatívno-pátracej činnosti a vyšetrovania pri poznávaní trestných činov.
THE IMPACT OF DIGITAL TECHNOLOGIES ON THE COMMUNICATION OF STUDENTS
Authors: Krikun Vladimir Grigorievich , Krikun Elena Vladimirovna
Published: July 2023

The article examines the features of communicative (information exchange), interactive (organization of joint activities) and perceptual (emotional function) aspects of communication among students in a digital society.
STRATEGY FOR THE DEVELOPMENT OF THE RAILWAY INFRASTRUCTURE OF THE PEOPLE’S DEMOCRATIC REPUBLIC OF ALGERIA
Authors: Fekir Kahina
Published: July 2023

The history and prospects for the development of railway transport in the Republic of Algeria is provided. For more than 100 years, the railways of Algeria were built by French occupation forces, starting in 1857 when the first 1357 kilometers of standard network lines were constructed. Currently, railway construction continues by Algerian companies, and the length of railway lines in Algeria is approximately 4600 kilometers. At the level of goals, Algerian railways, after gaining independence in 1962, moved from the logic of exploiting natural resources to the logic of the state strategy for the development of railway transport infrastructure, and currently the strategy focuses on integration into the modern production and marketing chain.
ANALYSIS OF THE FOUNDATIONS OF TRADITIONAL SPIRITUAL AND MORAL EDUCATION IN THE EDUCATIONAL SPACE OF MODERN SOCIETY
Authors: Burlyaeva Victoria Arsentievna , Oleshkevich Tatiana Adolfovna , Solovyova Natalia Vladimirovna , Chebanov Konstantin Alexandrovich
Published: July 2023

This article analyzes the basics of traditional spiritual and moral education, its main goal of assimilation of spiritual values by adolescents and their implementation into practical action; analyzes the concept of "spirituality"; provides a number of recommendations for the spiritual and moral education of the younger generation in the modern educational space.
ANALYSIS OF TECHNICAL PERFORMANCE OF HIGHLY QUALIFIED ATHLETES IN THE DISCIPLINE OF INDIVIDUAL TRAMPOLINE JUMPING
Authors: Парахин Виктор Александрович , Захарчук Мария Сергеевна
Published: July 2023

В статье представлен сравнительный анализ технического исполнения соревновательных комбинаций, которые были выполнены юниорами и юниорками в финалах соревнований на национальных стартах в начале 2023 года.

The article presents a comparative analysis of the technical execution of competitive combinations that were performed by juniors and juniors in the finals of competitions at national starts in early 2023.
THE METHOD FOR CALCULATING THE FLOW CHARACTERISTICS AND SEPARATION INDICATORS OF A NEW DESIGN VORTEX DUST COLLECTOR
Authors: Романюк Роман Владимирович , Лагуткин Михаил Георгиевич
Published: July 2023

От выбора конструктивных и режимных параметров работы вихревых пылеуловителей (ВПУ) зависят энергетические затраты на обеспечение необходимой эффективности пылеулавливания при заданной объемной производительности по очищаемому газу. Приведены данные по наиболее рациональным конструктивным параметрам завихрителей ВПУ. На основе аналитических зависимостей и данных компьютерного моделирования разработана методика расчета гидравлического сопротивления ВПУ новой конструкции и его разделяющей способности.

The choice of design and operational parameters of the vortex dust collectors (VDC) influences the energy costs to ensure the required efficiency of dust collection at a given volumetric productivity of the gas being cleaned. The article presents data on the most rational design parameters of the swirlers of the VDC. On the basis of analytical dependencies and computer simulation data, a method for calculating the pressure drop of a new design VDC and its separating ability has been developed.
RESULTS OF THE APPLICATION OF BLOOD-SAVING TECHNOLOGIES WHEN PERFORMING EXTENSIVE RESECTIONS OF STUFF DUE TO ECHINOCOCCOSIS
Authors: Краснов Аркадий Олегович
Published: July 2023

В статье представлены результаты применения кровесберегающих технологий при выполнении обширных резекций печени по поводу распространенного эхинококкоза.

The article presents the results of the use of blood-saving technologies when performing extensive liver resections for widespread echinococcosis.