bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term efficacy and safety of netakimab in patients with active ankylosing spondylitis: results of three years of use in the international multicentre, randomized, double-blind, phase III clinical trial BCD-085-5/ASTERA
Authors: Mazurov V. I. , Erdes Sh. F. , Gaydukova I. Z. , Dubinina T. V. , Pristrom A. M. , Kunder E. V. , Soroka N. F. , Kastanayan A. A. , Povarova T. V. , Zhugrova E. S. , Plaksina T. V. , Shesternya P. A. , Kropotina T. V. , Antipova O. V. , Smolyarchuk E. A. , Tsyupa O. A. , Abdulganieva D. I. , Lapshina S. A. , Krechikova D. G. , Gordeev I. G. , Nesmeyanova O. B. , Ilivanova E. P. , Strelkova A. V. , Tyrenko V. V. , Mikhailova E. A. , Eremeeva A. V.
Published: February 2024

The article presents the results of the three-year use of netakimab (NTK) in patients with ankylosing spondylitis (AS) as part of the phase III BCD-085-5/ASTERA study.

Objective: to evaluate the long-term efficacy and safety of NTK over a three-year period in patients with active AS.

Material and methods. BCD-085-5/ASTERA – double-blind, multicenter, randomized phase III clinical trial that enrolled patients with active AS (BASDAI ≥4) and a back pain intensity ≥4 on a numeric rating scale with inefficacy or intolerance of non-steroidal anti-inflammatory drugs or biologic drugs. A total of 228 patients were randomized in a 1:1 ratio and assigned to either the NTK group or the placebo/NTK group. Starting at week 16, patients who did not achieve ASAS20 (20% improvement according to ASAS criteria) received NTK 120 mg once every 2 weeks in an open-label regimen. Patients who achieved ASAS20 response at week 52 in the NTK group and week 68 in the placebo/NTK group continued to receive NTK (120 mg every 2 weeks) until week 156 in the NTK group and until week 172 in the placebo/NTK group.

Results and discussion. Over the course of three years of NTK use, most patients experienced a sustained decline in AS activity (according to ASDAS-CRP, BASDAI) with sustained response (ASAS20/40, ASAS5/6) to therapy. Most adverse events reported were mild to moderate. 36.7% of patients had adverse events, which were mainly laboratory abnormalities, blood and lymphatic system abnormalities and infectious complications.

Conclusion. The clinical effect of NTK was maintained in most patients with AS over a three-year period, with no significant loss of response. NTK was well tolerated and the safety profile remained favorable.
Alflutop Russian longitudinal multicenter observational study: use in patients with chronic back pain (message 3)
Authors: Lila A. M. , Karateev A. E. , Alexeeva L. I. , Taskina E. A. , Danilov An. B. , Zhivolupov S. A. , Samartsev I. N. , Barantsevich E. R. , Rachin A. P.
Published: February 2024

The use of slow-acting disease-modifying symptomatic drugs, such as bioactive concentrate from small marine fish (BCSMF, Alflutop), is considered a potential element of complex therapy for chronic non-specific back pain (CNBP).

Objective: to evaluate the efficacy of the BCSMF in patients with CNBP in real-life clinical practice.

Material and methods. An open observational study included 10,047 patients with CNBP (age – 58.3±14.9 years, 58.4% women) with moderate or severe pain – 60 [50; 70] mm on the visual analogue scale (VAS). All patients received a course of BCSMF medication: 1 ml intramuscular (IM) daily No. 20 or 2 ml IM every other day No. 10. 68.8 % of patients also took non-steroidal anti-inflammatory drugs. Treatment outcomes were assessed 10 days after completion of BCSMF therapy (30 days after initiation of treatment).

Results and discussion. As a treatment result, the pain intensity according to the VAS decreased from 60 [50; 70] to 20 [10; 30] mm (p<0.0001), the patients’ overall health assessment according to the VAS increased from 50 [30; 60] to 80 [60; 90] mm (p><0.0001) and the quality of life assessment (EQ-5D) – from 0.52 [0.06; 0.66] to 0.8 [0.71; 1] points (p>< 0.0001). A good response to treatment (pain reduction >50%) was observed in 73% of patients. On average, an improvement was observed on the 8th [5; 10] day of BCSMF therapy. There were no serious adverse effects associated with the use of the drug. Older age, overweight, initially more severe pain, and the presence of comorbid conditions were slightly more frequently associated with a less pronounced response to therapy.

Conclusion. The use of BCSMF rapidly and effectively reduces the severity of pain and other symptoms associated with CNBP.
Issues of contraception in rheumatic diseases: current status of the problem and perspectives
Authors: Panevin T. S. , Smetnik A. A. , Dubinina T. V.
Published: February 2024

Contraception is an important aspect of reproductive health in patients with rheumatic diseases. This is primarily due to the fact that in most immuneinflammatory rheumatic diseases (IRD) pregnancy must be planned. On one hand, the presence and activity of IRD can influence the course of the pregnancy, but on the other hand, pregnancy, which is accompanied by changes in general hormonal levels, is often a factor that alters the activity of IRD. Some patients take medication with potentially teratogenic effects. Planning a pregnancy during IRD can contribute to its optimal progression and minimize the risks of exacerbation of IRD. Given the wide range of barrier and hormonal contraceptives currently in use and the introduction of new drugs into clinical practice, data on the possibility of their use are of particular importance to rheumatologists in practical healthcare.
Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis
Authors: Kouhpayeh Hamidreza , Naderi Mohammad , Mohammadghasemipour Zahra , Bahari Gholamreza , Elahian Nastaran , Taheri Mohsen , Hashemi Mohammad
Published: February 2024

There is little data regarding the impact of renin-angiotensin system (RAS) gene polymorphisms on tuberculosis. The current study designed to survey the possible association between RAS polymorphisms and the risk of pulmonary tuberculosis (PTB) in a sample of the southeast Iranian population. This case-control study was done on 170 PTB patients and 170 healthy subjects. The AGT rs699 C>T, ACE rs4341 C>G and AT1R rs5186 C>A variants were genotyped using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and ACE rs4646994 (287bp I/D) variant by PCR method. Regarding AT1R rs5186 A>C polymorphism, the findings revealed that AC genotype and C allele significantly decreased the risk of PTB (OR=0.39, 95% CI=0.22–0.67, p=0.001, and OR=0.53, 95% CI=0.25–0.72, p=0.002, C vs. A, respectively). The TC genotype and C allele of AGT rs699 T>C significantly associated with decreased the risk of PTB (OR=0.45, 95% CI=0.28–0.74, p=0.002, TC vs. TT and OR=0.51, 95% CI=0.32–0.80, p=0.005, C vs. T, respectively). The ID genotype of ACE 287bp I/D significantly increased the risk of PTB (OR=1.88, 95% CI=1.12–3.17, p=0.017). Our finding did not support an association between ACE rs4341 C>G variant and the risk of PTB. In summary, the findings revealed an association between AT1R rs5186 A>C, AGT rs699 T>C and ACE 287bp I/D polymorphisms and the risk of PTB in a sample of the southeast Iranian population. Further investigation with higher sample sizes and diverse ethnicities are required to confirm our findings.
La conexión emocional en la comunidad : actividades para su fortalecimien
Authors: Ayala Rodríguez Nelly , Villamil Reina Angie Lorena , Ruiz Basto Andrea Lorena , Ardoryan Machado María Luisa
Published: February 2024

La presente cartilla está pensada para ser utilizada por los profesionales que acompañan a las comunidades, en sus diversos proyectos, en especial cuando el proceso en el que se encuentran especifica la necesidad de fortalecer la conexión emocional entre los miembros. Esta propuesta se inscribe en la perspectiva de tener un país más solidario, más compasivo y amoroso, en el que fácilmente se pueda evidenciar su gran riqueza humana y cultural. La responsabilidad en la reconstrucción del país es de todos y todas, independientemente del rol que desempeñemos. En la perspectiva de dar vida a este llamado y aportar al fortalecimiento de la conexión emocional dentro de las comunidades, con esta cartilla se espera que los gestores comunitarios, líderes sociales, docentes y todos los profesionales que adelantan trabajo de acompañamiento a las comunidades, y que consideren necesario fortalecer la afectividad y la confianza entre los miembros, puedan hacerlo a través del desarrollo de las actividades aquí planteadas.
Pathophysiology Manifestations of SARS-CoV-2: A Comprehensive Review
Authors: Sonam Bhutia , Pem Lhamu Bhutia
Published: February 2024

Coronaviruses (CoVs) are wrapped up positive-sense RNA viruses, classified by Club-like spikes that stretch across the surface and follow exceptionally large RNA genomes and unique amplification mechanisms. The diseases caused by coronaviruses in animals and birds range from potentially fatal respiratory infections in humans to enteritis in pigs, cattle, and poultry with upper respiratory illnesses. Here, we provide a short overview of viruses, including their morphology, categorization, mechanisms of replication, and pathogenicity, particularly in humans, as well as the most recent approaches to COVID-19 prevention and therapy. We have presented the pandemic virus relationships with pathophysiological human conditions like blood group cases and age group mortality, the effect on men's fertility and obstetricians in pregnant women, and also address the outbreaks greatly pathogenic SARS-CoV (“Severe Acute Respiratory Syndrome Coronavirus”) &MERS-CoV (“Middle East Respiratory Syndrome”) recently reported. The novel coronavirus disease (COVID-19) is a pandemic cause for the whole world so its scientific data or information will be beneficial for the research and development in the recent scenario as well as for future perspective.
Insect as food: search for new protein dietary sources – A review
Authors: Parvin Ismat , Gope Arpita , Khanrah Jayeeta , Anjali Rawani
Published: February 2024

The increasing global need for food has sparked a great deal of interest in the consumption of novel and diversified sources of protein. Dietary protein not only plays a critical function in the prevention of Protein Energy Malnutrition (PEM) but also in how the human diet affects the environment. Eating insects has been practised for a very long time. Edible insects have clear economic and environmental benefits, and recently, their huge potential in numerous industries has brought them to the forefront. Due to cultural prejudices towards hazardous insects, edible insects in Western nations are more likely to be used as animal feed than as human food, even though their abundance should be advantageous to human health. However, insects are a major source of protein for many countries in Asia, Africa, and Latin America. Insects may be used to address issues with the conservative food supply chain, such as the scarcity of land, water, and energy resources. Our analysis shows that, despite the fact that consumers affected by Western eating habits are unfamiliar with it, entomophagy is steadily growing throughout the world. Numerous studies have been done to increase their value, however questions about the security of the food supply have been raised. In this review of literature study, comparison have been made with ingestible insects with those of other conventional protein sources. The development of contemporary entomophagy was discussed along with their historical perspective. The practical methods and tactics has been also suggested to encourage the consumption of edible insects.
Defective antibody production in double-strand DNA breakage syndromes: insights and implications
Authors: Shafiei Mohammadreza , Jamee Mahnaz
Published: February 2024

DNA double-strand breakage (DSB) syndrome are rare monogenic inborn errors of immunity with a vast spectrum of manifestations. In addition to a high predisposition to malignancies, these patients are also at risk of recurrent, severe, or opportunistic infections. Therefore, monitoring of immunoglobulin levels and responses to vaccination, as well as interventions such as immunoglobulin replacement therapy should be considered to improve the patients’ outcomes. As DNA double-strand breakage repair pathways have a great impact on lymphocyte development through involvement in the generation of B and T cell receptors, disruption in one of their components may lead to genomic instability, aberrant B-cell receptor (BCR)/T-cell receptor (TCR) development, impaired B cell lymphocyte development and antibody production. The aim of this review is to describe the most common of DBSs, such as ataxia telangiectasia (AT), AT-like disorder (ATLD), Nijmegen breakage syndrome (NBS), Nijmegen breakage syndrome-like disorder (NBSLD), Bloom syndrome (BS), Fanconi anemia (FA) and some others with a focus on the role of DNA repair proteins in the development of humoral immunity. We also describe the immunoglobulin profile, recommendations for diagnosis, screening, and interventions for the ideal management of affected patients.
High Levels of Mutant Huntingtin Protein in Tear Fluid From Huntington’s Disease Gene Expansion Carriers
Authors: Gijs Marlies , Jorna Nynke , Datson Nicole , Beekman Chantal , Dansokho Cira , Weiss Alexander , Linden David E. J. , Oosterloo Mayke
Published: February 2024

Objective Huntington’s disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects middle-aged adults. HD is caused by a CAG repeat expansion in the HTT gene, resulting in the expression of mutant huntingtin (mHTT). Our aim was to detect and quantify mHTT in tear fluid, which, to our knowledge, has never been measured before.Methods We recruited 20 manifest and 13 premanifest HD gene expansion carriers, and 20 age-matched controls. All patients underwent detailed assessments, including the Unified Huntington’s Disease Rating Scale (UHDRS) total motor score (TMS) and total functional capacity (TFC) score. Tear fluid was collected using paper Schirmer’s strips. The level of tear mHTT was determined using single-molecule counting SMCxPRO technology.Results The average tear mHTT levels in manifest (67,223 ± 80,360 fM) and premanifest patients (55,561 ± 45,931 fM) were significantly higher than those in controls (1,622 ± 2,179 fM). We noted significant correlations between tear mHTT levels and CAG repeat length, “estimated years to diagnosis,” disease burden score and UHDRS TMS and TFC. The receiver operating curve demonstrated an almost perfect score (area under the curve [AUC] = 0.9975) when comparing controls to manifest patients. Similarly, the AUC between controls and premanifest patients was 0.9846. The optimal cutoff value for distinguishing between controls and manifest patients was 4,544 fM, whereas it was 6,596 fM for distinguishing between controls and premanifest patients.Conclusion Tear mHTT has potential for early and noninvasive detection of alterations in HD patients and could be integrated into both clinical trials and clinical diagnostics.
Variabilidade química do óleo essencial de Piper obliquum Ruiz & Pavan. coletada na Estação Ecológica de Cuniã, Porto Velho-Rondônia
Authors: Rojas e Silva Aizzo Jussara , Manzatto Angelo Gilberto , Felipe Sampaio Adeilza , Soares Azevedo Mariangela
Published: February 2024

A sazonalidade é um dos fatores que influenciam no metabolismo secundário das plantas, afetando a composição dos óleos essenciais. A família Piperaceae tem importância ecológica e econômica, sendo a Piper obliquum Ruiz & Pav. representante dessa família. Esta espécie é denominada pelos índios Yanomani de Papiu como xama-hanaki. A planta foi coletada na Estação Ecológica de Cuniã, Porto Velho, Rondônia, em cinco períodos do ano, abrangendo os meses de outubro, novembro de 2011 e fevereiro, maio e agosto de 2012. A extração do óleo essencial foi realizada por meio da hidrodestilação e análise do material foi através de cromatografia a gás associada à espectrometria de massas. Os componentes determinados nas foram majoritariamente da classe dos terpenos, onde o maior teor foi de α-pineno, canfeno e β-pineno. A análise de agrupamento hierárquico resultou na formação de grupos distintos para as amostras nos meses de outubro, novembro e agosto para os períodos de fevereiro e maio. Através da Análise de Correspondência Múltipla (ACM) e Análise de Componentes Principais (ACP) verificou-se que alguns constituintes não apresentaram variações significativas, porém muitas substâncias demonstraram correlação positiva concernente ao período coletado. A maioria dos compostos apresentou baixa composição independente do período coletado. A variação química observada dos espécimes obtidos nos diferentes meses corrobora com a influência do ambiente na variação dos componentes do metabolismo secundário dos vegetais.
The Effect of Green Human Resources Management Practices on Corporate Sustainability from the Perspective of Employees
Authors: Nart Sima , Bilgili Ahmet , Orgut Emine Demet
Published: February 2024

This study examines the impact of Green Human Resources Management (GHRM) in the textile and fashion industry on corporate sustainability (CS). In addition, the indirect effects of organizations’ environmental performance (EP) and employee commitment to CS are also examined. The research was carried out with the participation of the employees (n = 129) of Turkish organizations operating in the fashion and textile sector that adopt a sustainable business management approach. Structural equation modeling via smart PLS was used for data analysis. The findings showed that GHRM positively affects CS, and EP mediates this relationship. However, employee commitment did not have a mediating effect in this relationship. These results provide CS experts and managers with evidence-based insights into designing GHRM practices and sustainability strategies.
Risks in Identifying Gifted Students in Mathematics: Case Studies
Authors: Budínová Irena
Published: February 2024

The article discusses the risks involved in identifying gifted students in mathematics in the school environment. Although the theory of gifted students is widespread and available today, school practice shows many cases of gifted students who have not been identified in the school environment. The reasons for this are various. The article will present the theory related to this topic. The research was conducted as two case studies using qualitative research methods. Semi-structured interviews with parents and pupils were used, and the pupils were observed for a long time by the researcher. In the first case, it was a mathematically gifted pupil with dyslexia, and in the second case, it was a mathematically gifted pupil with an extremely high IQ. The result of the study was to find out in which moments the school did not provide support to the pupil in the two cases mentioned and what kind of help the pupil would appreciate at school. Both pupils were involved in a 1-year intervention in which the intention was to cultivate their mathematical thinking and expressions with the help of appropriately chosen tasks. The stated findings are important for practice and discussion about the training of future mathematics teachers, for which consistent professional training focusing, among other things, also on the education of gifted students is essential. Both case studies are part of long-term research dealing with the identification of gifted students.
Imaging in reconstructive microsurgery – current standards and latest trends
Authors: Blank Beate , Cai Aijia
Published: February 2024

In microsurgery, many different imaging techniques are available in both flap and lymphatic surgery that all come with their own advantages and disadvantages. In flap surgery, CT angiography is considered as the gold standard. Among others, Doppler ultrasound, color Doppler ultrasound, ICG, and smartphone-based thermal cameras are valuable imaging techniques. In lymphatic surgery, photoacoustic imaging, laser tomography, contrast-enhanced magnetic resonance imaging, and high frequency ultrasound stand available to surgeons next to the current standard of lymphoscintigraphy. It is crucial to know the advantages and disadvantages to various techniques and highly adviced to microsurgeons be capable of using a variety of them.
Thermally tunable binary-phase VO2 metasurfaces for switchable holography and digital encryption
Authors: Liao Yuan , Fan Yulong , Lei Dangyuan
Published: February 2024

Metasurface holography has aroused immense interest in producing holographic images with high quality, higher-order diffraction-free, and large viewing angles by using a planar artificial sheet consisting of subwavelength nanostructures. Despite remarkable progress, dynamically tunable metasurface holography in the visible band has rarely been reported due to limited available tuning methods. In this work, we propose and numerically demonstrate a thermally tunable vanadium dioxide (VO2) nanofin based binary-phase metasurface, which generates holographic information in the visible varying with temperature. The insulator-to-metal phase transition in VO2 nanofins allows two independent binary-phase holograms generated by machine learning to be encoded in the respective phases of VO2 and switched under thermal regulation. By elaborately designing the dimensions and compensated phase of VO2 nanofins, high-quality images are reconstructed at corresponding temperatures under appropriate chiral illumination. In contrast, much poorer images are produced under inappropriate chiral illumination. We further demonstrate the advantage of applying the VO2 phase-compensated metasurface in high-security digital encryption, where two desired character combinations are read out with appropriate excitations and temperatures, whereas one identical fraudulent message is received with inappropriate excitations. Our design approach offers a new and efficient method to realize tunable metasurfaces, which is promisingly adopted in dynamic display, information encryption, optical anti-counterfeiting, etc.
Single flake homo p–n diode of MoTe2 enabled by oxygen plasma doping
Authors: Zulfiqar Irsa , Gul Sania , Sohail Hafiz Aamir , Rabani Iqra , Gul Saima , Rehman Malik Abdul , Wabaidur Saikh Mohammad , Yasir Muhammad , Ullah Inam , Khan Muhammad Asghar , Rehman Shania , Khan Muhammad Farooq
Published: February 2024

Two-dimensional (2D) materials play a crucial role as fundamental electrical components in modern electronics and optoelectronics next-generation artificial intelligent devices. This study presents a methodology for creating a laterally uniform p–n junction by using a partial oxygen plasma-mediated strategy to introduce p-type doping in single channel MoTe2 device. The MoTe2 field effect transistors (FETs) show high electron mobility of about ∼23.54 cm2 V−1 s−1 and a current ON/OFF ratio of ∼106 while p-type FETs show hole mobility of about ∼9.25 cm2 V−1 s−1 and current ON/OFF ratio ∼105 along with artificially created lateral MoTe2 p–n junction, exhibited a rectification ratio of ∼102 and ideality factor of ∼1.7 which is proximity to ideal-like diode. Thus, our study showed a diversity in the development of low-power nanoelectronics of next-generation integrated circuits.
Zugang zu Forschungsdaten in den D-A-CH-Ländern: Eine Vermessung der (Un-)Zufriedenheit
Authors: Chaskel Rico , Getzner Michael , Fürnkranz-Prskawetz Alexia , Riphahn Regina T. , Schmidheiny Kurt
Published: February 2024

Umfassender Zugang zu relevanten Daten ist eine wesentliche Voraussetzung für exzellente Forschung und evidenzbasierte Wirtschaftspolitik. In diesem Beitrag sind die Ergebnisse gleichlautender Erhebungen der drei wirtschaftswissenschaftlichen Vereinigungen in Deutschland, Österreich und der Schweiz zur Zufriedenheit mit der Dateninfrastruktur unter Forschenden zusammengefasst. Die Zufriedenheit ist bestenfalls befriedigend, von einer exzellenten Ausstattung mit Daten sind die drei Länder noch weit entfernt. Die wesentlichen Probleme sehen die Befragten in der nicht ausreichenden Qualität und Aktualität, im ungenügenden Umfang und in der Unregelmäßigkeit der Daten. Zusätzlich fehlt häufig eine Verknüpfbarkeit bestehender Daten aus unterschiedlichen Quellen. Neben der dadurch beeinträchtigten Forschung hat eine ungenügende Dateninfrastruktur weitreichende Implikationen: Evidenzbasierte Politik- und Planungsentscheidungen im öffentlichen wie im privaten Sektor werden erschwert. Dies hat erhebliche Bedeutung für das Vertrauen in politische Entscheidungen und damit für die künftige politische Entwicklung insgesamt.
Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis
Authors: Wang Xin-Xin , Chen Wen-Zhi , Li Cheng , Xu Ren-Shi
Published: February 2024

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease which damages upper and lower motor neurons (UMN and LMN) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related UMN and LMN, accompanying with the pathological signs leaded by the cortical spinal lateral tract lesion. The pathogenesis about ALS is not fully understood, and no specific drugs are available to cure and prevent the progression of this disease at present. In this review, we reviewed the structure and associated functions of copper-zinc superoxide dismutase 1 (SOD1), discuss why SOD1 is crucial to the pathogenesis of ALS, and outline the pathogenic mechanisms of SOD1 in ALS that have been identified at recent years, including glutamate-related excitotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, axonal transport disruption, prion-like propagation, and the non-cytologic toxicity of glial cells. This review will help us to deeply understand the current progression in this field of SOD1 pathogenic mechanisms in ALS.
Evaluation of Test Methods and Environmental Conditions to Promote Efflorescence Formation Under Laboratory Conditions
Authors: Vickers T , Moukwa M
Published: February 2024

Several test procedures that induce formation of efflorescence on the surface of porous block specimens were investigated. This paper describes the tests that were investigated and the environmental conditions under which these tests were performed. A wicking procedure, run at an elevated temperature and low relative humidity, rapidly produces efflorescence on the surface of test samples. The rate of efflorescence formation was fastest at an elevated temperature and lower relative humidity and slowest at a cool temperature and high relative humidity. The wicking test can be used to rapidly determine the effect of changing mix proportion and the effectiveness of sealers and anti-efflorescence additives on the efflorescence potential of porous masonry units.
Pontas bifaciais e lesmas miniaturizadas:
Authors: Moreno João Carlos , João Cláudio Estaiano  , Maria Keiko Yamauchi  , Juliana de Souza Cardozo  , Uelde Ferreira de Souza  , Claudio César de Souza e Silva
Published: February 2024

Pesquisas sobre sítios arqueológicos associados a grupos caçadores-coletores no estado de Goiás têm revelado, desde a década de 1970, uma alta produção de artefatos líticos unifaciais alongados, conhecidos na literatura acadêmica brasileira como ‘lesmas’. Neste mesmo contexto, a presença de pontas de dardos ou flechas produzidas por tecnologias líticas bifaciais tem se mostrado escassa, com casos muito esporádicos reportados em poucos locais, e geralmente interpretada como exceções à norma cultural regional ou evidências de contato com grupos meridionais. Estes grupos caçadores-coletores foram associados por diversos pesquisadores a uma única unidade cultural que ficou conhecida como “Tradição Itaparica”, criando a ideia de uma suposta homogeneidade cultural que se estenderia do Centro-Oeste ao Nordeste brasileiro. Ao mesmo tempo que outros pesquisadores questionaram a validade desta “tradição” que seria baseada apenas na presença de lesmas e escassez de tecnologias bifaciais, e sem uma devida análise das demais classes de vestígios líticos que compõem toda a indústria. Neste artigo apresentamos um estudo tecnológico de um conjunto de artefatos identificados em cinco sítios arqueológicos situados nos municípios de Planaltina e Água Fria de Goiás, no leste de Goiás. Este conjunto de artefatos é constituído de dezenas de lesmas miniaturizadas, algumas pré-formas bifaciais, uma ponta pedunculada, alguns percutores e uma lâmina de machado polido. Os resultados deste estudo sugerem que a associação de sítios arqueológicos à “Tradição Itaparica” não deve ser realizada de forma prematura considerando apenas a presença abundante de uma única classe de artefato formal, como a lesma, uma vez que este mesmo artefato pode apresentar variabilidade tecnológica e/ou tipológica regional e/ou cronológica.
Limited Restoration of Contrast Sensitivity with Training after V1 Damage in Humans
Authors: Yang (杨菁艺) Jingyi , Saionz Elizabeth L. , Cavanaugh Matthew R. , Fahrenthold Berkeley K. , Melnick Michael D. , Tadin Duje , Briggs Farran , Carrasco Marisa , Huxlin Krystel R.
Published: February 2024

Stroke damage to the primary visual cortex (V1) causes severe visual deficits, which benefit from perceptual retraining. However, whereas training with high-contrast stimuli can locally restore orientation and motion direction discrimination abilities at trained locations, it only partially restores luminance contrast sensitivity (CS). Recent work revealed that high-contrast discrimination abilities may be preserved in the blind field of some patients early after stroke. Here, we asked if CS for orientation and direction discrimination is similarly preserved inside the blind field, to what extent, and whether it could benefit from a visual training intervention. Thirteen subacute patients (<3 months post-V1 stroke) and 12 chronic patients (>6 months post-V1 stroke) were pretested and then trained to discriminate either orientation or motion direction of Gabor patches of progressively lower contrasts as their performance improved. At baseline, more subacute than chronic participants could correctly discriminate the orientation of high-contrast Gabors in their blind field, but all failed to perform this task at lower contrasts, even when 10 Hz flicker or motion direction were added. Training improved CS in a greater portion of subacute than that of chronic participants, but no one attained normal CS, even when stimuli contained flicker or motion. We conclude that, unlike the near-complete training-induced restoration of high-contrast visual discrimination abilities, V1 damage in adulthood may severely limit the residual visual system's ability to regain normal CS. Our results support the notion that CS involves different neural substrates and computations than those required for orientation and direction discrimination in V1-damaged visual systems.
Lifetimes and timescales of tropospheric ozone
Authors: Prather Michael J. , Zhu Xin
Published: February 2024

The lifetime of tropospheric O3 is difficult to quantify because we model O3 as a secondary pollutant, without direct emissions. For other reactive greenhouse gases like CH4 and N2O, we readily model lifetimes and timescales that include chemical feedbacks based on direct emissions. Here, we devise a set of artificial experiments with a chemistry-transport model where O3 is directly emitted into the atmosphere at a quantified rate. We create 3 primary emission patterns for O3, mimicking secondary production by surface industrial pollution, that by aviation, and primary injection through stratosphere–troposphere exchange (STE). The perturbation lifetimes for these O3 sources includes chemical feedbacks and varies from 6 to 27 days depending on source location and season. Previous studies derived lifetimes around 24 days estimated from the mean odd-oxygen loss frequency. The timescales for decay of excess O3 varies from 10 to 20 days in northern hemisphere summer to 30 to 40 days in northern hemisphere winter. For each season, we identify a single O3 chemical mode applying to all experiments. Understanding how O3 sources accumulate (the lifetime) and disperse (decay timescale) provides some insight into how changes in pollution emissions, climate, and stratospheric O3 depletion over this century will alter tropospheric O3. This work incidentally found 2 distinct mistakes in how we diagnose tropospheric O3, but not how we model it. First, the chemical pattern of an O3 perturbation or decay mode does not resemble our traditional view of the odd-oxygen family of species that includes NO2. Instead, a positive O3 perturbation is accompanied by a decrease in NO2. Second, heretofore we diagnosed the importance of STE flux to tropospheric O3 with a synthetic “tagged” tracer O3S, which had full stratospheric chemistry and linear tropospheric loss based on odd-oxygen loss rates. These O3S studies predicted that about 40% of tropospheric O3 was of stratospheric origin, but our lifetime and decay experiments show clearly that STE fluxes add about 8% to tropospheric O3, providing further evidence that tagged tracers do not work when the tracer is a major species with chemical feedbacks on its loss rates, as shown previously for CH4.
АКТУАЛЬНІ АСПЕКТИ ФОРМУВАННЯ ПРОФЕСІЙНОЇ ГОТОВНОСТІ МАЙБУТНІХ ФАРМАЦЕВТІВ
Authors: КУЗЕНКО ОЛЕКСАНДРА , ЛЕОЧКО НАТАЛІЯ
Published: February 2024

У статті розкриваються актуальні аспекти формування професійної готовності майбутніх фармацевтів. Обґрунтовано, що впровадження сучасних підходів до організаційно-педагогічної діяльності в ЗВО суттєво активізує  пізнавальну діяльність здобувачів, позитивно впливає на формування  майбутніх фармацевтів з прогресивним способом мислення, здатних розв’язувати інноваційні завдання сучасної фармацевтичної галузі. Аргументується, що дієвим чинником формування фахової готовності здобувачів вищої фармацевтичної освіти стало впровадження компетентнісного і студентоцентрованого підходів до організації навчально-виховного процесу в ЗВО.
ПОГЛЯДИ МИТРОПОЛИТА АНДРЕЯ ШЕПТИЦЬКОГО НА МОРАЛЬНО-СВІТОГЛЯДНЕ ВИХОВАННЯ МОЛОДІ
Authors: МАТКОВСЬКИЙ МИХАЙЛО
Published: February 2024

У статті проаналізовано погляди митрополита Андрея Шептицького на морально-світоглядне виховання молоді. Досліджується роль інститутів сім’ї та школи у процесі виховання і становлення молоді. Обґрунтовано важливість плекання у молоді високих ідеалів на основі християнських цінностей. Аргументується важливість власної праці над самим собою. Проведено аксіологічну паралель Шептицький – сучасність. Доведено актуальність виховних ідей митрополита Андрея Шептицького для сьогодення. Аргументується актуальність усебічного та різнопланового огляду й переосмислення його спадщини.
СУЧАСНІ ПРОГРЕСИВНІ МЕТОДИКИ ВИКЛАДАННЯ ПРИРОДНИЧИХ ДИСЦИПЛІН У МЕДИЧНИХ ЗАКЛАДАХ ВИЩОЇ ОСВІТИ
Authors: ДАНИЛІВ СВІТЛАНА , Нечитайло Лариса , Кривов’яз Оксана
Published: February 2024

У статті автори наголошують на використанні сучасних педагогічних технологій як багатогранному процесі, який є важливим соціальним інститутом, процесом, що безпосередньо формує засвоєння знань. Доведено, що сучасні педагогічні технології вимагають нових освітніх методів, нових підходів, нової технології процесу одержання знань, і це пов’язано з тим, що педагогічні процеси набувають інформаційного характеру і спостерігається зміщення акцентів у навчанні з процесу накопичення предметних знань на вироблення умінь автономно застосовувати їх у ситуації багатозадачності. Сучасні педагогічні технології вимагають вдало обґрунтованої цільової, змістовно-інформаційної, виховної, інтелектуальної складової та відповідного навчального середовища, і їх застосування сприятиме не лише високому інтелектуальному розвитку особистості, але й дозволить розвивати організаційні, лідерські якості особистості.
ПРИНЦИПИ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВИХ КЛАСІВ ДО РЕАЛІЗАЦІЇ РІЗНОМАНІТНИХ РОЛЕЙ В ІНКЛЮЗИВНОМУ ОСВІТНЬОМУ ПРОСТОРІ
Authors: АКІМОВА Олена
Published: February 2024

Професійна підготовка майбутніх фахівців спеціальності 013 Початкова освіта до реалізації різноманітних ролей в інклюзивному освітньому просторі здійснюється за паралельною моделлю. Зважуючи на необхідність упровадження цілісного підходу рівнів методології (філософський, загальнонауковий, конкретно-науковий та конкретно-фаховий), основними принципами підготовки майбутніх фахівців спеціальності 013 Початкова освіта до реалізації різноманітних ролей в інклюзивному освітньому просторі визначені: синергітизм, науковість, культуро-відповідність, едукаційность, гуманізація діяльності, об’єктивність, своєчасність, цілеспрямованість. Схарактеризовано ролі тьютора, ментора, коуча, фасилітатора майбутнього вчителя початкових класів, що відповідають основним засадам реалізації інклюзивної форми навчання в початковій школі.
Review: Biochemical Additives for Papermaking
Authors:   North Carolina State University, Department of Forest Biomaterials Raleigh, North Carolina, United States of America, Pawlak Joel J.
Published: February 2024

Biochemical additives encompass materials added to the papermaking operation that are derived from biological origins. Other than starch, the majority of the biochemical additives currently used in the paper industry are enzymatic. Enzymes are protein structures that speed a particular chemical reaction. The enzymes are not consumed during the reaction and can be used repeatedly. The enzymes used in the paper industry typically target one of the four major components of wood: cellulose, hemicellulose, lignin or extractives. Enzymes have been used industrially to aid in bleaching, reduce pitch, enhance strength, alter pulp freeness, and aid in paper machine cleaning. This review focuses on the use of enzymes in the papermaking operation, but also addresses the use of enzymes in other areas of the pulp and paper mill. There has also been considerable work in the use of fungus for improving both mechanical and chemical pulping operations. This is considered a separate topic and is only brieﬂy addressed in this review. The future of biochemical additives may extend well beyond the current use of enzymes and a few notes on potential application are given.
Clima organizacional y satisfacción laboral de los trabajadores de una empresa peruana
Authors: Tinoco Plasencia Christian Jairo
Published: February 2024

Organizational climate is a crucial factor that influences job satisfaction among workers in any organization. This research aims to describe the perceived levels of organizational climate and job satisfaction among workers in a Peruvian company and determine the relationship between both variables. This is a basic, non-experimental, and correlational quantitative study. The sample consists of 40 workers employed in a civil construction company in Lima, Peru, and is a census sample. Organizational climate and job satisfaction questionnaires were used to collect data, with 28 and 25 items, respectively. The results report that organizational climate and job satisfaction reached moderate levels, with 62.50% and 60.00%, respectively. Based on the obtained Spearman’s rho value of 0.755 and a p-value of 0.000 < 0.05, it was determined that there exists a significant and high direct relationship between the variables under study.
Primer registro de la abeja colectora de óleo Centris (Odontoxys) melanochlaena Smith, 1874 (Hymenoptera, Apidae) en Nicaragua
Authors: Quiroz-Medina Conrado Ronaldo , Vivallo Felipe
Published: February 2024

The first report of the oil-collecting bee Centris (Odontoxys) melanochlaena Smith, 1874 in Nicaragua is presented. This species occurs in several Central American countries and Mexico, being this the first record from western Nicaragua. This record contributes to the knowledge of the distribution range of this species, as well as increases the list of native bees occurring in Nicaragua.
The pre-Colombian roads of geoglyphs sites in the state of acre: the tequinho site road complex
Authors: Barros De Souza Rubens
Published: February 2024

This article prioritized studying the roads and paths that are interconnected to geoglyph-type sites in the Western Brazilian Amazon, not only because of their originality, but also to understand some issues that permeate the universe of geoglyphs, such as how was gave the spatial distribution of these roads in the region, what meaning they had within the sociocultural context of that society. For a more detailed analysis, the Tequinho site was used as the main object of the research, its characteristics and location being what most contributed to its choice, given that it is in the center of the region where the geoglyphs occur, and several roads and paths are linked to the site, and are noticeable in the landscape. The Tequinho site is understood as a public center for cultural and religious events, and its roads and paths are seen as central props in ritualistic ceremonies, as well as markers and boundaries in the landscape. This article also addresses the importance of the Iquiri River, which works, was part of the context of a land-fluvial network in the region of geoglyphs, in the east of the State of Acre, Brazil. During this work, ethno-historical sources were used as a theoretical framework, as well as the perspective of landscape archeology.
Autism spectrum disorder-from genetics to intervention
Authors: Vieira Daniela , Figueira Ana Paula Couceiro
Published: February 2024

The Autism Spectrum Disorders (ASD) is developmental disorders that affect individuals at different levels - behavioral, linguistic and social–and in different magnitudes (APA, 2013).1 This is a disorder that has been studied a lot in recent times, due to the exponential increase in cases. However, it continues to leave many in conclusions due to its heterogeneity. In this article we intend to create an overview of this problem, from its causes to the intervention that still obtains better scientific results, the ABA behavioral therapy (Applied Behavior Analysis).
Who Was Felix Lavenue?
Authors: Jenkins Terry
Published: February 2024

Explores the career and influence of the chief instructor at a school of cookery in London during the 1860s.
You Can't Beat an Egg
Authors: Richardson Steven D P
Published: February 2024

The author provides some observations regarding egg cookery followed by several recipes.
Ramen – A Japanese National Dish with Chinese National Heritage
Authors: Kushner Barak
Published: February 2024

The article is a reworking, by the author, of the first chapter of Slurp! A Social and Culinary History of Ramen – Japan’s Favorite Noodle Soup which was published in 2012 by Brill. It provides a history of traditional ramen as well as its offshoot, instant noodles.
Polo and Human Evolution. The Essentialisation of the Human Body
Authors: Byrne Beatriz
Published: February 2024

A review of Leonardo Polo’s thought about human evolution in light of the last three decades of palaeontological and archaeological findings and developments. The understanding of human evolution as the essentialisation of the human body allows for the integration of those discoveries and developments in his Transcendental Anthropology.
Reseña de libro: L. Polo, Escritos para la Cátedra (Juan A. García, ed.), en Obras Completas, Serie B, vol. XXXV. EUNSA, Pamplona, 2023, 277 pp.
Authors: Sellés Juan-Fernando
Published: February 2024

Book Review
Reseña de libro: M. C. Barbosa Brou, El estatuto científico de la Psicología según Leonardo Polo. Sindéresis, Madrid, 2023, 656 pp.
Authors: Millán-Ghisleri Elda
Published: February 2024

Book Review
Reseña de libro: Gonzalo Alonso-Bastarreche, El sistema de la persona humana. Una introducción a la Antropología. Sindéresis, 2023, Madrid, 209 pp.
Authors: León-Parodi Joaquín
Published: February 2024

Book Review
Adolfo Meisel Roca. Santa Bárbara de Las Cabezas: La gran hacienda del caribe colombiano 1742-1942. Barranquilla: Universidad del Norte, 2023.
Authors: López Enciso Enrique
Published: February 2024

Meisel exhibía el mapa como si este fuera una preciosa joya, parte de un tesoro más grande, un archivo que había logrado rescatar del olvido y el polvo. Compartí su entusiasmo porque pronto reconocí que tenía en sus manos un hallazgo que es el sueño de un historiador, como son los registros desconocidos de una hacienda, de un convento, o de una oficina pública. Esos son los anales preciados de los historiadores para poder hacer estudios de caso bien documentados, como este que viene a sumarse al de las haciendas Berástegui y Martha Magdalena, ubicadas en la Costa Atlántica, y que son fundamentales para entender la historia agraria de nuestro país y de la región Caribe. Anticipaba que Adolfo iba a construir un análisis a partir de ese insumo originario, con el rigor al que nos tiene acostumbrados.
A descontinuidade do tempo de trabalho na agricultura e as implicações sobre a estabilidade da empresa capitalista - uma análise da visão de Marx
Authors: BAIARDI AMILCAR
Published: February 2024

RESUMO Alguns autores brasileiros que utilizam uma abordagem marxista, têm insistido na inviabilidade da produção capitalista privada. As premissas desta tese são: 1) a diferença existente no processo de produção agrícola entre o tempo de trabalho e o tempo de produção e 2) a hipotética menor taxa de lucro da agricultura capitalista. Este artigo tenta mostrar que essas premissas são falsas uma vez que o processo de produção foi tão alterado pela agricultura moderna que se tornou muito semelhante à indústria.
Nitrogen and potassium interaction in oxisol soils under BRS 394 wheat cultivation
Authors: Paludo Juliana T. S. , Bonfim-Silva Edna M. , Silva Tonny J. A. da , Meneghetti Luana A. M. , Oliveira Niclene P. R. de
Published: February 2024

ABSTRACT Potassium and nitrogen are essential nutrients and their uptake and distribution within plants must be coordinated for optimum growth and development. We evaluated the interaction between nitrogen and potassium fertilization on the development of BRS 394 wheat, and the nitrate and ammonium levels in Oxisol soils. A 52 factorial design was used in a greenhouse experiment, with four replicates in randomized blocks, corresponding to five doses of nitrogen (0, 70, 140, 210, and 280 mg dm-3) and five doses of potassium (0, 50, 100, 150, and 200 mg dm-3). The variables analyzed were shoot dry mass; chlorophyll index; nitrate reductase; nitrogen, potassium, and protein concentrations in the leaves; and nitrate and ammonium levels in the soil. There was an interaction between nitrogen and potassium doses on the chlorophyll index, with nitrogen doses between 152.67 and 163.53 mg dm-3 and potassium of 191.50 mg dm-3 providing the highest chlorophyll index. The other variables were influenced separately by the nitrogen dose. The highest nitrate reductase enzyme activity was 1.30 µmol NO h-1 g-1 Fresh Matter, which was reached at a nitrogen dose of 95 mg dm-3. Shoot dry mass, concentrations of nitrogen and total protein in the leaves, and concentrations of nitrate and ammonium in the soil were adjusted to the linear regression model as a function of nitrogen fertilization. The dose of nitrogen that promoted the best development of BRS 394 wheat and the highest concentrations of nitrate and ammonium in Oxysol soils was 280 mg dm-3.